Miracle-dz/UniFAR-FTUs huggingface dataset:
Forecast Uncertainty Dynamics in the THORPEX Interactive Grand Global Ensemble (TIGGE)

AbstractThis paper employs local linear, spatial spectral, and Lorenz curve–based diagnostics to investigate the dynamics of uncertainty in global numerical weather forecasts in the NH extratropics. The diagnostics are applied to ensembles in the THORPEX Interactive Grand Global Ensemble (TIGGE). The initial growth of uncertainty is found to be the fastest at the synoptic scales (zonal wavenumbers 7–9) most sensitive to baroclinic instability. At later forecast times, the saturation of uncertainties at the synoptic scales and the longer sustainable growth of uncertainty at the large scales lead to a gradual shift of the wavenumber of the dominant uncertainty toward zonal wavenumber 5. At the subsynoptic scales, errors saturate as predicted by Lorenz’s classic theory. While the ensembles capture the general characteristics of the uncertainty dynamics efficiently, there are locations where the predicted magnitude and structure of uncertainty have considerable time-mean errors. In addition, the magnitude of .
IsoGeometric Analysis: Stable elements for the 2D Stokes equation

In this paper, we discuss the application of IsoGeometric Analysis to incompressible viscous flow problems. We consider, as a prototype problem, the Stokes system and we propose various choices of compatible spline spaces for the approximations to the velocity and the pressure fields. The proposed choices can be viewed as extensions of the Taylor–Hood, Nédélec and Raviart–Thomas pairs of finite element spaces, respectively. We study the stability and convergence properties of each method and discuss the conservation properties of the discrete velocity field in each case. Copyright © 2010 John Wiley & Sons, Ltd.
Digital Twins in Healthcare: A Survey of Current Methods

Digital twin technology has been increasingly applied in healthcare and patient well-being in recent years. This paper provides an overview of the current methods and applications of digital twins in the healthcare field. One such application is digital twins in precision healthcare, where digital twins are used to create patient-specific models to assist in diagnosis and treatment planning. Digital twins are also used in hospital/clinic management, where they help to optimize resource allocation and workflow processes. In response to the COVID-19 pandemic, digital twins have been utilized to detect outbreaks and predict disease spread. In addition, digital twins have been applied in bio-manufacturing and pharmaceutical industry to improve manufacturing processes. Another application area is machine learning and modeling, where digital twins are used in machine learning, data generation, and system modeling for applications in healthcare and disease prediction. Security and ethical issues related to digital twins are also discussed in this paper, as privacy concerns and data protection remain important considerations in the application of digital twin technology in healthcare. Finally, the paper concludes by discussing the future challenges and directions of future work in this field. These include the need to develop more accurate and sophisticated digital twin models, addressing interoperability and integration issues, and further exploring the potential of digital twin technology in emerging areas such as telemedicine and personalized medicine.
Transudative Malignancy: Uncommon and Real

Light’s criteria are the cornerstone to differentiate exudates from transudates. The traditional literature states that malignant pleural effusions are rarely transudative; therefore, cytology tends to be low yield and not a cost-effective decision. This case describes an 82-year-old female who developed a transudative pleural effusion despite having an underlying malignancy, highlighting the importance of integrating clinical judgment into pursuing thoracentesis with the cytological examination.
A Comparison Between Ultrasound Pachymetry and CASIA2 (Anterior-Segment Optical Coherence Tomography) in the Measurement of Central Corneal Thickness

Background and objective Due in part to its effect on intraocular pressure (IOP) measurements, the assessment of central corneal thickness (CCT) is recognized as an essential part of the initial glaucoma assessment. The most widely utilized clinical technique to measure CCT is ultrasound pachymetry (USP). In recent years, many dedicated anterior-segment optical coherence tomography scanners (AS-OCTs) have been developed. Previous studies have compared CCT measurements between USP and various AS-OCTs. This study aimed to assess the degree of agreement between USP and CASIA2 (Tomey Corporation, Nagoya, Japan), a second-generation swept-source AS-OCT developed in Japan. Methodology The data on CCT screening measurements of 156 eyes (88 patients) performed over a period of three months, from January to March 2020, on glaucoma patients attending the Royal Hallamshire Hospital (RHH) in Sheffield, UK were collected retrospectively and statistically analyzed. Results The average age of the 88 patients included in the study was 66 years (range: 20-86 years). Our findings show that when compared to CASIA2 measurements, USP measurement of the CCT resulted in significantly thicker values (paired t-test: t=23.15,p<2.2 x 10-16). The average difference between the two methods was 19.98 ± 10.78 μm. It is hypothesized that this difference may be due in part to inaccurate probe placement during ultrasound probe measurement, resulting in thicker CCT values. Conclusion The observed difference may be clinically significant as it could induce clinical discrepancy in terms of perceived glaucoma risk in patients. Therefore, USP and CASIA2 should not be used interchangeably, and clinicians should take into account the significant difference between these methods.
Employees Motivation and Financial Performance of Hotel Business in Rwanda: A case Study of Hill-Top Hotel and Country Club

The purpose of this study was to assess the effects of employee motivation on financial performance of hotel business in Rwanda with a case of Hill-Top Hotel and Country Club. The following specific objectives guided the study: To identify the different types of employee motivation, to find out the contribution of employee motivation to the financial performance, to determine the challenges facing employee motivation at Hill-Top Hotel and Country Club. The study sample size was 39. The questionnaire and interview guide were used to collect primary data. The results indicated the major type of employee motivation used by Hill-Top Hotel and Country Club was an improved working environment with a rate of 26%. The findings also revealed that Hill-Top Hotel and Country Club maintains employee motivation by increasing employee performance leading to the contribution of financial performance at a rate of 36%. Finally, the findings showed that 33.3% of the respondents answered that poor understanding of the motivations behind repeat bookings as a major challenge facing employee motivation at Hill-Top Hotel and Country Club. In conclusion, employee motivation contributes to the financial performance of hotel businesses. The researcher recommends that Hill-Top Hotel and Country Club should hire more trained and motivated employees. by improving the work environment and having motivated employees who are familiar with assigned tasks, could increase employee performance and contribute to the finance performance. This would ensure that the efficiency and effectiveness of the organization are enhanced.
Patients' Views on Medical Events in Lung Cancer Screening as Teachable Moments for Smoking Behaviour Change: A Systematic Review and Metasynthesis

Although medical events in lung cancer screening (LCS) such as receiving scan results or interactions with clinicians are recognised as teachable moments (TMs), the views of patients about why this is the case for smoking behaviour change remain uncertain. This systematic review and metasynthesis study is aimed at identifying the reasons why patients believed that medical events during LCS act as TMs for smoking behaviour change. A search strategy was developed for use with MEDLINE, PsycINFO, EMBASE, CINAHL-P, Web of Science databases, and Google Scholar. This helped identify qualitative and mixed-method research which mentioned patients' views of how these TMs result in smoking behaviour change. After screening, final articles were critically appraised; general characteristics and data relevant to the aims were extracted to conduct a line-of-argument metasynthesis. After screening 695 papers, 11 were included. Undergoing LCS scans was seen to act on their intrinsic motivation to reduce smoking as it served as a “wake-up call” and increased awareness of the health consequences of smoking. Receiving positive or negative LCS results resulted in cessation as it was a “health scare” and challenged smoking habits. Interactions with clinicians addressed misconceptions and signposted them to specialist cessation services. Attendees believed that the following encouraged them to change their smoking behaviour: having an intrinsic motivation to quit, their beliefs on smoking and health reframed, their negative emotions appraised, and using LCS to access specialist support. In line with the TM heuristic, these experiences provided the necessary skills, confidence, and motivation to quit. Future research should explore whether the views of the clinicians match those of the attendees to address misconceptions and further develop clinical guidelines.
Brain Gym Therapy: Focus Attention as an Effort to Improve Student Learning Concentration

Currently, all levels of education carry out the learning process online. They start from primary, secondary, to higher education. At the higher education level, students who usually do face-to-face learning activities face-to-face with other lecturers and students now must do the same activities virtually. This study aims to analyze whether there are differences in the concentration level in the study of students after being treated with brain gym therapy with the PACE movement. This study uses an experimental approach with a two-group pre and post-test design. The subjects of this study were 60 students divided into two groups, 30 in the experimental group and 30 in the control group, who met the research criteria. The data analysis technique used paired sample t-test. The results showed that there was a difference in learning concentration for students after being given PACE brain gym therapy with the results of the paired sample t-test with a value of = 0.042 (p less than 0.05). There is no difference in learning concentration for students after being given brain gym therapy material and learning concentration with the results of the paired sample t-test with a value of = 0.82 (p more than 0.05). Through this study, students' learning concentration can be improved by doing pace brain gym therapy movements. Increasing student concentration can be increased by doing brain gym therapy as a habit every time before doing learning activities that are expected to help increase student concentration.
Kompakte Sterne in der Branenwelt

Diese Arbeit behandelt kompakte Sterne in der Branenwelt. Die Tolman- Oppenheimer-Volkoff-Gleichungen der stellaren Struktur werden fur einen Stern auf der Brane hergeleitet. Um dieses Gleichungssystem zu schliesen, wird angenommen, dass die Komponenten des projizierten Weyl-Tensors eine Art Zustandsgleichung P = wU erfullen, was eine Relation zwischen dem isotropen und anisotropen Druck des effektiven Weyl-Fluids darstellt. Schlieslich werden die Branen-TOV-Gleichungen fur Neutronensterne und Weise Zwerge numerisch gelost, wobei insbesondere der inhomogene Dich- teverlauf im Sterninneren duch Verwendung realistischer Zustandsglei- chungen der Sternmaterie berucksichtigt wird. Aus dem Vergleich mit Be- obachtungsdaten ergeben sich Einschrankungen an die Parameter lambda (Bra- nenspannung) und w des Modells. %%%%The following study focuses on compact stars in the braneworld. The Tolman-Oppenheimer-Volkoff equations of stellar structure are derived for a star on the brane. In order to close this system of equations, I assume, that the components of the projected Weyl tensor obey an equation-of- state like relation P = wU, which is a relation between the isotropic and anisotropic pressure of the effective Weyl fluid. The brane-TOV equations are solved numerically for neutron stars and white dwarfs, taking into ac- count the inhomogeneous density profile in the stellar interior via realistic equations of state for the stellar matter. Comparison with observational data leads to constraints on the parameters lambda (the brane tension) and w of the model.
Downstream Amplification: A Possible Precursor to Major Freeze Events over Southeastern Brazil

Abstract Many frost events over southeastern Brazil are accompanied by a large-amplitude upper trough of the middle latitudes that extends well into the Tropics. This paper first illustrates that a mechanism of downstream amplification across the Pacific into South America is generally accompanied in these situations. This is manifested by troughs and ridges that propagate eastward. An analysis of these situations during frost events shows that these features of downstream amplification, illustrated on a Hovmoller (x–t) plot, can be decomposed into a family of synoptic-scale waves that propagate eastward and a family of planetary-scale waves that acquire a quasi-stationary character during the freeze event. It is shown that a global model, at a resolution of 70 km, can be used to predict these features on the decomposition of scales during freeze events. It became apparent from these features that the growth of the long stationary waves during the freeze events may be due to scale interaction among wave c.
Optimal control problems for variational inequalities with controls in coefficients and in unilateral constraints

We deal with an optimal control problem for variational inequalities, where the monotone operators as well as the convex sets of possible states depend on the control parameter. The existence theorem for the optimal control will be applied to the optimal design problems for an elasto-plastic beam and an elastic plate, where a variable thickness appears as a control variable.
Judgments of 3D Bars in Depth

Twenty participants judged the relative size of two bars portrayed at different locations in a 3D bar graph. Bars were co-located, placed side by side (near adjacent), or the small bar occluded the large (near or far occluded). Error was greater for the far occluded condition and there was greater variability in bias scores. To account for observed error, we proposed a model that distinguishes between cyclical bias commonly observed in proportion judgments and bias resulting from improper size-distance scaling. The model was fit to data, and the results indicated that the absolute value of size-distance scaling parameter γ was greater in the far occluded condition. Inclusion of γ increased R 2 for far and near occluded conditions only. Bar location did not affect cyclical bias. Thus, judgments of the relative sizes of bars in 3D bar graphs showed increased error when the bars were separated, due to inaccurate size-distance scaling.
A Fractional Generalised Finite Difference Method to Linear Porous Media Dynamics

The generalised finite difference method (GFDM) is a mesh-free method for solving partial differential equations (PDEs) in non-structured grids. Due to its strong theoretical background and simplicity, hence efficiency, it has been introduced to handle interesting and sophisticate engineering problems. However, the GFDM has not been applied to problems associated to dynamics of porous media yet. In these problems, the strong coupling between solid displacements and liquid pressures may cause large numerical oscillations if equal order interpolation functions are used for both variables. Nevertheless, some fractional steps techniques can be introduced in order to minimise these problems. In this contribution, a fractional steps scheme is developed and applied to the GFDM in order to model fully saturated porous media dynamics. Simulations of 1D and 2D wave propagation are performed in order to reveal the advantages, drawbacks and capabilities of the proposed method.
The magnetization behavior and open recoil loops of hot-deformed Nd-Fe-B magnets infiltrated by low melting point PrNd-Cu alloys

Ultrahigh coercivity of hot-deformed Nd-Fe-B magnets was obtained by low melting point PrNd-Cu alloys diffusion process. The coercivity was largely increased from 15.35 to 27.30 kOe. Magnetic isolation by nonmagnetic phases should be the primary explanation for the enhancement of coercivity. High susceptibility of the recoil loops at low field indicated that magnetic domain wall motion within grains was easy, while a near-zero reversible susceptibility of recoil loops implied that domain wall strong pinning at grain boundaries was dominant at higher field in initial magnetization process. Open recoil loops were also obtained in the infiltrated magnets and disappeared when the external field exceeded about 16 kOe lightly higher than the coercivity of the magnet without diffusion process. The inhomogeneous distribution of infiltrated phases that led to the grains aggregation and single grains with softer and harder magnetic characteristics, respectively, may be the primary reason for the phenomenon. The stray field produced by isolated single grains plays a critical role in the magnetization behavior. A phenomenological model for the magnetization reversal was built to interpret the open recoil loops in a recoil loop process.
Information Abundance and Deficit

The article presents a methodological analysis of Elfreda Chatman’s research on marginal populations. Revisiting the methodological legacy and influence of Chatman’s research addresses positioning of the marginal within information environments in the presentation of theory. The position of deficit or lack in the communities under study are juxtaposed with abundance revealed in differing forms of Chatman’s research. This article first reviews how Chatman’s work challenges methodological hegemonic practices of theory development in Library and Information Science (LIS) research. Secondly, three works are analyzed for methodological approach and processes in theory development. Each article is observed in terms of design, approach, researcher (role, voice, position, posture), and theory development (as a methodological construct). Lastly, recommendations on impact of methodological approach and positioning reveal the impetus for the proposed article, deconstructing the researcher and their extension of theory-making in marginal spaces. Pre-print first published online 09/30/2022
Results from the MORPHEUS-liver study: Phase Ib/II randomized evaluation of tiragolumab (tira) in combination with atezolizumab (atezo) and bevacizumab (bev) in patients with unresectable, locally advanced or metastatic hepatocellular carcinoma (uHCC).

4010 Background: Atezo + bev is the current first-line standard of care for uHCC based on the IMbrave150 study, which demonstrated superior overall survival, progression-free survival (PFS), and objective response rate (ORR) vs sorafenib (Finn, et al. New Engl J Med 2020; Cheng, et al. J Hepatol 2022). TIGIT is a novel inhibitory immune checkpoint present on activated T cells and NK cells. Tira (anti-TIGIT) may synergize with other immunotherapies, such as PD-L1/PD-1 inhibitors. The MORPHEUS platform comprises multiple phase Ib/II trials to identify early efficacy signals and safety of treatment combinations across cancers. Here we report data from a cohort of the MORPHEUS-liver study (NCT04524871) evaluating the combination of tira + atezo + bev vs a control arm (atezo + bev) in patients with uHCC. Methods: Patients with previously untreated uHCC were randomized to receive atezo (1200mg IV) + bev (15mg/kg IV) with or without tira (600mg IV) every three weeks. The primary endpoint was investigator-assessed ORR by RECIST V1.1. Secondary endpoints included PFS and safety. Results: A total of 58 patients were randomized (tira + atezo + bev, n=40; atezo + bev, n=18). As of 28 November 2022, median follow up was 14.0 months in the tira + atezo + bev arm and 11.8 months in the control arm. Confirmed ORR was higher in the tira + atezo + bev arm (42.5%) vs the control arm (11.1%). Median PFS was longer with tira + atezo + bev (11.1 months; 95% CI: 8.2–NE) vs control (4.2 months; 95% CI: 1.6–7.4), corresponding to a PFS hazard ratio (HR) of 0.42 (95% CI: 0.22–0.82). A similar pattern of increased ORR and PFS was observed for the treatment arms in both PD-L1+ (n=23) and PD-L1– (n=27) subgroups. For tira + atezo + bev vs control arm, grade 3/4 treatment-related AEs were 27.5% vs 33.3% and AEs leading to any treatment discontinuation were 22.5% vs 22.2%, respectively. Conclusions: The addition of tira to atezo + bev resulted in higher ORR and longer PFS compared with atezo + bev, and no new safety signals were identified. These data suggest that tira + atezo + bev may be a promising novel first-line treatment option for patients with uHCC, and support further study in this setting. Clinical trial information: NCT04524871 . [Table: see text]
Some modular relations of order six with its applications to partitions

In the paper, we establish some modular relations involving cubic functions which are analogous to Ramanujan's forty identities. We also give new proof of some modular relations of the same nature established earlier by C. Adiga, K. R. Vasuki and N. Bhaskar. Furthermore, we extract interesting partition results from some of our modular relations.
Lefschetz properties for arithmetic real and complex hyperbolic manifolds

(Lefschetz theorem). The purpose of this paper is to point out an analogous, still mostly conjectural, result for arithmetic real and complex hyperbolic manifoldsM = Γ\X obtained as quotient of a real or complex hyperbolic space X = G(R)/K∞ ,where G is a semisimple group over Q and K∞ ⊂ G(R) a maximal compact subgroup, by an arithmetic subgroup Γ of G(Q). A great deal of work has been done by, amongst others, Kazhdan, Millson, and Li in order to understand which (co)homology classes occur in such quotients. The geometrical way in which these classes occur remains anyway very mysterious. The methods used by the above cited authors do not allow any explicit geometrical realization. There are still two big exceptions:
On the size-dependent flexural vibration characteristics of unbalanced couple stress-based micro-spinning beams

ABSTRACT On the basis of the modified couple stress theory, some analytical results are obtained for vibrational parameters of micro-spinning Rayleigh beams with an axial mass-eccentricity distribution. The modified couple stress theory is a nonclassical continuum theory capable to capture the size effects in small-scale structures. After writing the governing equations of motion, they are transformed to the complex form. Then by utilizing the Galerkin method, analytical expressions for natural frequencies of the micro-spinning beam in forward and backward whirl motions are obtained. Critical speeds are also analytically presented in the two whirl motions for different modes. Moreover, the vibrational amplitude of the micro-spinning beam with axial mass eccentricity distribution is determined. Some numerical results are presented to study the effect of the length scale parameter on the vibrational characteristics.