Miracle-dz/UniFAR-FTUs huggingface dataset:
Green entrepreneurial orientation, boundary-spanning search and enterprise sustainable performance: The moderating role of environmental dynamism

As an important strategic decision for enterprise sustainability, the green entrepreneurial orientation can facilitate boundary-spanning search for external knowledge and resources to achieve triadic sustainable economic, environmental, and social performance. Based on organizational search theory and dynamic capability theory, this study introduces environmental dynamism into the model of the relationship between green entrepreneurial orientation, boundary-spanning search and enterprise triadic sustainable performance. By analyzing the questionnaire data from 202 managers of manufacturing SMEs, the study explores the internal and external influences of green entrepreneurial orientation on the enterprise sustainable performance. The results show that: green entrepreneurial orientation has a positive impact on enterprise economic, environmental and social performance; boundary-spanning search plays a fully mediating role between green entrepreneurial orientation and enterprise economic, environmental and social performance; environmental dynamism, as a key external environmental factor, positively regulates the relationship between boundary-spanning search and enterprise economic performance and environmental performance, and negatively regulates the relationship between boundary-spanning search and social performance. This study clearly demonstrates how green entrepreneurial orientation in the environmental era can drive triadic sustainable performance improvement of enterprises. In addition, this study argues that boundary-spanning search is an important tool that enables manufacturing SMEs to achieve a triad of coordinated sustainable development of economic, environmental and social benefits in a dynamic environment.
Modeling systems from partial observations

Modeling systems from collected data faces two main difficulties: the first one concerns the choice of measurable variables that will define the learnt model features, which should be the ones concerned by the addressed physics, optimally neither more nor less than the essential ones. The second one is linked to accessibility to data since, generally, only limited parts of the system are accessible to perform measurements. This work revisits some aspects related to the observation, description, and modeling of systems that are only partially accessible and shows that a model can be defined when the loading in unresolved degrees of freedom remains unaltered in the different experiments.
Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases

Interferons (IFNs) bind to cell surface receptors and activate the expression of interferon-stimulated genes (ISGs) through intracellular signaling cascades. ISGs and their expression products have various biological functions, such as antiviral and immunomodulatory effects, and are essential effector molecules for IFN function. ISGs limit the invasion and replication of the virus in a cell-specific and region-specific manner in the central nervous system (CNS). In addition to participating in natural immunity against viral infections, studies have shown that ISGs are essential in the pathogenesis of CNS disorders such as neuroinflammation and neurodegenerative diseases. The aim of this review is to present a macroscopic overview of the characteristics of ISGs that restrict viral neural invasion and the expression of the ISGs underlying viral infection of CNS cells. Furthermore, we elucidate the characteristics of ISGs expression in neurological inflammation, neuropsychiatric disorders such as depression as well as neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Finally, we summarize several ISGs (ISG15, IFIT2, IFITM3) that have been studied more in recent years for their antiviral infection in the CNS and their research progress in neurological diseases.
Combining organic and conservation agriculture to restore biodiversity? Insights from innovative farms in Belgium and their impacts on carabids and spiders

Conservation and organic agriculture are two alternative crop management strategies associated with environmental impact reduction, leading theoretically to more biodiversity and higher ecological functioning, underpinning better ecosystem service delivery. The combination of these two farming strategies is increasingly seen as an opportunity to mitigate shortcomings of each of them taken individually. However, combining organic and conservation agriculture is undeniably challenging, since it leaves no curative option (neither synthetic pesticides nor soil plowing) for pest control (phytophagous, pathogens, and weeds). Hence, the latter must be ensured by effective restoration of predatory communities. The present research investigated the potential of combining organic and conservation agriculture to support two major ground-dwelling natural enemy communities: carabids and spiders. We used pitfall traps to sample these two communities in paired adjacent cereal fields conducted under organic-conservation (OC) and conventional (CV) agriculture in Belgium. Community assemblages were significantly different across system types, both in terms of species diversity and functional trait diversity. OC parcels showed higher alpha and beta species diversities for both carabids and spiders and species composition differed between OC and CV parcels. OC systems were associated with higher variation of species assemblages among parcels than CV systems Functional traits also differed across system types for both groups. We found more herbivorous and granivore carabids in OC parcels, and more predator species in CV parcels. We found larger spiders, more hunting spiders and more wetland spiders in OC parcels, whereas we found more web weavers and more forest spiders in CV ones. Functional diversity was higher in OC parcels for carabids, but not for spiders. In brief, OC parcels supported more diverse communities, both taxonomically and functionally. These outcomes show that OC systems are promising systems to support these natural enemy communities. Further studies should assess whether combining organic and conservation agricultural enables sufficient pest control levels to achieve high levels of food production and farmers income.
A lower-limit flux for the extragalactic background light

Context. The extragalactic background light (EBL) contains information about the evolution of galaxies from very early times up to the present. The spectral energy distribution is not known accurately, especially in the near- and mid-infrared range. Upper limits and absolute measurements come from direct observations which might be be polluted by foreground emission, while indirect upper limits can also be set by observations of high energy gamma-ray sources. Galaxy number counts integrations of observable galaxies, missing possible faint sources, give strict lower limits. Aims. A model is constructed, which reproduces the EBL lower limit flux. This model can be used for a guaranteed minimum correction of observed spectra of extragalactic gamma-ray sources for extragalactic absorption. Methods. A forward evolution model for the metagalactic radiation field is used to fit recent observations of satelites like Spitzer, ISO, Hubble and GALEX. The model is applied to calculate the Fazio-Stecker relation, and to compute the absorption factor at different redshifts and corrected blazar spectra. Results. A strict lower-limit flux for the evolving extragalactic background light (and in particular the cosmic infrared background) has been calculated up to a redshift of five. The computed flux is below the existing upper limits from direct observations, and agrees with all existing limits derived from very-high energy gamma-ray observations. The corrected spectra still agree with simple theoretical predictions. The derived strict lower-limit EBL flux is very close to the upper limits from gamma-ray observations. This is true for the present day EBL, but also for the diffuse flux at higher redshift. Conclusions. If future detections of high redshift gamma-ray sources require a lower EBL flux than derived here, the physics assumptions used to derive the upper limits have to be revised. The lower-limit EBL model is not only needed for absorption features in active galactic nuclei and other gamma-ray sources, but is also essential when alternative particle processes are tested, which could prevent the high energy gamma-rays from being absorbed. It can also be used for a guaranteed interaction of cosmic-ray particles. The model is available online.
COVID-19, lifestyle behaviors and mental health: A mixed methods study of women 6 months following a hypertensive pregnancy

Introduction The COVID-19 pandemic introduced unprecedented challenges to both the physical and psychological health of postpartum women. The aim of this study was to determine how the COVID-19 pandemic affected the diet, physical activity and mental health of women 6 months following a hypertensive disorder of pregnancy. Methods Mixed methods sub-study of the Blood Pressure Postpartum trial, which recruited women following a hypertensive disorder of pregnancy from six Sydney metropolitan hospitals. Cross sectional analysis of baseline quantitative data, collected at 6-months postpartum from March 2019-February 2022, and qualitative data analysis from semi-structured telephone interviews, was performed. Dates of COVID-19 lockdowns for Sydney, Australia were collected from government websites. Diet (vegetable, fruit, alcohol, take away intake) and physical activity (walking, vigorous activity, strength training frequency and duration) were assessed using the self-report NSW Population Health Survey. Depression and anxiety were assessed using the Edinburgh Depression Scale and GAD-7 scale, respectively. Outcome data were compared between women who completed surveys “In Lockdown” vs. “Not in Lockdown” as well as “Prior to any Lockdown” vs. “During or Following any Lockdown”. Results Of 506 participants, 84 women completed the study surveys “In Lockdown,” and 149 completed the surveys “Prior to any Lockdown. ” Thirty-four participants were interviewed. There were no statistically significant differences in diet, physical activity, depression and anxiety among women who completed the survey “In Lockdown” vs. “Not in Lockdown. ” “Prior to any Lockdown,” participants were more likely to do any walking (95% vs. 89%, p = 0.017), any vigorous activity (43% vs. 30%, p = 0.006) or any strength training (44% vs. 33%, p = 0.024), spent more time doing vigorous activity (p = 0.003) and strength training (p = 0.047) and were more likely to drink alcohol at least monthly (54% vs. 38%, p < 0.001) compared with “During or Following any Lockdown. ” Conclusions Our findings suggest that the confinements of lockdown did not markedly influence the mental health, diet and physical activity behaviors of women 6 months following hypertensive pregnancy. However, physical activity levels were reduced following the emergence of COVID-19, suggesting targeted efforts may be necessary to re-engage postpartum women with exercise. Trial registration https://anzctr.org. au/Trial/Registration/TrialReview.aspx? id=376286&isReview=true, identifier: ACTRN12618002004246.
Growth differentiation factor-15 as a modulator of bone and muscle metabolism

This study aims to clarify the potential role of growth differentiation factor-15 (GDF-15) as a myokine in bone metabolism and muscle function in females with osteoporosis. In total, 45 female participants (71.0 ± 8.5 years) with distal radius fractures were recruited. Participants were classified as healthy/osteopenic (n = 28) (CON) or osteoporotic (n = 17) (OP) according to their T-score from the areal bone mineral density (aBMD) of the femoral neck. Body mass index, upper arm and calf circumferences, and handgrip strength were assessed. Total hip, femoral neck, and lumbar spine aBMD was measured via dual-energy x-ray absorptiometry. The focal bone quality of the distal radius was evaluated via 3D reconstructed computed tomographic images. Serum levels of GDF-15, insulin-like growth factor-1, and inflammatory markers such as tumor necrosis factor-α (TNF-α), interleukin-6, and interleukin-1β (IL-1β), as well as the corresponding mRNA levels in the pronator quadratus muscle were determined. Participants in the OP group had higher serum GDF-15 levels than those in the CON group. The mRNA levels of GDF-15, IL-1β, and TNF-α in the pronator quadratus muscle were significantly higher in the OP group than in the CON one. Levels of both serum GDF-15 and GDF-15 mRNA in muscle were positively correlated with age and negatively associated with the aBMD of the total hip and focal bone quality of the distal radius. Handgrip power was not correlated with circulating GDF-15 levels but was correlated with circumferences of the upper arm and calf, and levels of GDF-15 mRNA in muscle specimens. The mRNA levels of GDF-15 were correlated with those of inflammatory cytokines such as TNF-α and IL-1β. The mRNA levels of TNF-α were associated with circumferences of the upper arm and calf and with the aBMD of the total hip. The mRNA levels of GDF-15 in muscle were correlated with serum levels of GDF-15 and TNF-α. GDF-15 may have associations with bone metabolism in humans via paracrinological and endocrinological mechanisms. Maintenance of muscle mass and function would be influenced more by GDF-15 in muscle than by circulating GDF-15. The role of GDF-15 in bone metabolism and muscle homeostasis could be related to inflammatory responses.
Integrated analysis of miRNA and mRNA expression profiles in testes of Landrace and Hezuo boars

Precocious puberty is closely related to testicular development and spermatogenesis, and there is increasing evidence that miRNAs are involved in regulation of testicular development and spermatogenesis. However, little is known about the regulation of microRNAs (miRNAs) during precocious maturation in Hezuo (HZ) boars. In this study, serum Testosterone (T), Estradiol (E2), Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) levels were detected in HZ and Landrace (LC) boars in the postnatal period at 30, 90, 120, 180, and 240 days, and the testes of HZ and LC boars at 30 and 120 days were used for histological observation. In addition, we performed small RNA-Seq to identify miRNA at sexual immaturity (30-days-old) and maturity (120-days-old) of HZ boar testis (using LC boar as control) to reveal the key miRNA in regulation of precocious puberty. Hormone assay results showed that high levels of T, E2, FSH, and LH may be related to precocious sexual maturity of HZ boars, and that FSH may play an important function before sexual maturity. Histological observation showed that HZ boars developed earlier than LC boars and had reached sexual maturity at 120 days. Small RNA-Seq yielded a total of 359 exist miRNAs, 767 known miRNAs and 322 novel miRNAs in 12 samples; 549, 468, 133, and 247 differentially expressed (DE) miRNAs were identified between Ha vs. Hb, La vs. Lb, Ha vs. La, and Hb vs. Lb (log2 fold change >1 and p < 0.05). Enrichment analysis showed that target genes of these DE miRNAs were enriched in many gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways (such as PI3K-Akt, Hippo and Rap1 signaling pathways) were related to testicular development and spermatogenesis. Further screening, some miRNAs (such as ssc-miR-29b, ssc-miR-199b, ssc-miR-383, ssc-miR-149, ssc-miR-615, and ssc-miR-370) were possibly associated with precocious puberty. These results provide new light on miRNA regulatory mechanisms involved in precocious puberty.
The effect of regional white matter hyperintensities on essential tremor subtypes and severity

Objectives To investigate the effect of regional white matter hyperintensities (WMHs) on Essential tremor (ET) subtypes and to explore the association between WMHs load and the severity of motor and non-motor symptoms in patients with ET. Methods A cohort of 176 patients with ET (including 86 patients with pure ET and 90 patients with ET plus) and 91 normal controls (NC) was consecutively recruited. Demographic, clinical, and imaging characteristics were compared between individuals with pure ET, ET plus, and NC. The cross-sectional association among regional WMHs and the severity of tremor and non-motor symptoms were assessed within each group. Results Compared with the pure ET subgroup, the ET plus subgroup demonstrated higher TETRAS scores, NMSS scores, and lower MMSE scores (all P < 0.05). Periventricular and lobar WMHs' loads of pure ET subgroup intermediated between NC subjects and ET plus subgroup. WMHs in the frontal horn independently increased the odds of ET (OR = 1.784, P < 0.001). The age (P = 0.021), WMHs in the frontal lobe (P = 0.014), and WMHs in the occipital lobe (P = 0.020) showed a significant impact on TETRAS part II scores in the ET plus subgroup. However, only the disease duration was positively associated with TETRAS part II scores in patients with pure ET (P = 0.028). In terms of non-motor symptoms, NMSS scores of total patients with ET were associated with disease duration (P = 0.029), TETRAS part I scores (P = 0.017), and WMH scores in the frontal lobe (P = 0.033). MMSE scores were associated with age (P = 0.027), body mass index (P = 0.006), education level (P < 0.001), and WMHs in the body of the lateral ventricle (P = 0.005). Conclusion Our results indicated that the WMHs in the frontal horn could lead to an increased risk of developing ET. WMHs may be used to differentiate pure ET and ET plus. Furthermore, WMHs in the frontal and occipital lobes are strong predictors of worse tremor severity in the ET plus subgroup. Regional WMHs are associated with cognitive impairment in patients with ET.
IAU 2015 Resolution B2 on Recommended Zero Points for the Absolute and Apparent Bolometric Magnitude Scales

The XXIXth IAU General Assembly in Honolulu adopted IAU 2015 Resolution B2 on recommended zero points for the absolute and apparent bolometric magnitude scales. The resolution was proposed by the IAU Inter-Division A-G Working Group on Nominal Units for Stellar and Planetary Astronomy after consulting with a broad spectrum of researchers from the astronomical community. Resolution B2 resolves the long-standing absence of an internationally-adopted zero point for the absolute and apparent bolometric magnitude scales. Resolution B2 defines the zero point of the absolute bolometric magnitude scale such that a radiation source with $M_{\rm Bol}$ = 0 has luminosity L$_{\circ}$ = 3.0128e28 W. The zero point of the apparent bolometric magnitude scale ($m_{\rm Bol}$ = 0) corresponds to irradiance $f_{\circ}$ = 2.518021002e-8 W/m$^2$. The zero points were chosen so that the nominal solar luminosity (3.828e26 W) adopted by IAU 2015 Resolution B3 corresponds approximately to $M_{\rm Bol}$(Sun) = 4.74, the value most commonly adopted in recent literature. The nominal total solar irradiance (1361 W/m$^2$) adopted in IAU 2015 Resolution B3 corresponds approximately to apparent bolometric magnitude $m_{\rm bol}$(Sun) = -26.832. Implicit in the IAU 2015 Resolution B2 definition of the apparent bolometric magnitude scale is an exact definition for the parsec (648000/$\pi$ au) based on the IAU 2012 Resolution B2 definition of the astronomical unit.
Judgment aggregation, discursive dilemma and reflective equilibrium: Neural language models as self-improving doxastic agents

Neural language models (NLMs) are susceptible to producing inconsistent output. This paper proposes a new diagnosis as well as a novel remedy for NLMs' incoherence. We train NLMs on synthetic text corpora that are created by simulating text production in a society. For diagnostic purposes, we explicitly model the individual belief systems of artificial agents (authors) who produce corpus texts. NLMs, trained on those texts, can be shown to aggregate the judgments of individual authors during pre-training according to sentence-wise vote ratios (roughly, reporting frequencies), which inevitably leads to so-called discursive dilemmas: aggregate judgments are inconsistent even though all individual belief states are consistent. As a remedy for such inconsistencies, we develop a self-training procedure—inspired by the concept of reflective equilibrium—that effectively reduces the extent of logical incoherence in a model's belief system, corrects global mis-confidence, and eventually allows the model to settle on a new, epistemically superior belief state. Thus, social choice theory helps to understand why NLMs are prone to produce inconsistencies; epistemology suggests how to get rid of them.
Metabolic fingerprinting of chemotherapy-resistant prostate cancer stem cells. An untargeted metabolomic approach by liquid chromatography-mass spectrometry

Chemoresistance is one of the most important challenges in cancer therapy. The presence of cancer stem cells within the tumor may contribute to chemotherapy resistance since these cells express high levels of extrusion pumps and xenobiotic metabolizing enzymes that inactivate the therapeutic drug. Despite the recent advances in cancer cell metabolism adaptations, little is known about the metabolic adaptations of the cancer stem cells resistant to chemotherapy. In this study, we have undertaken an untargeted metabolomic analysis by liquid chromatography–high-resolution spectrometry combined with cytotoxicity assay, western blot, quantitative real-time polymerase chain reaction (qPCR), and fatty acid oxidation in a prostate cancer cell line resistant to the antiandrogen 2-hydroxiflutamide with features of cancer stem cells, compared to its parental androgen-sensitive cell line. Metabolic fingerprinting revealed 106 out of the 850 metabolites in ESI+ and 67 out of 446 in ESI- with significant differences between the sensitive and the resistant cell lines. Pathway analysis performed with the unequivocally identified metabolites, revealed changes in pathways involved in energy metabolism as well as posttranscriptional regulation. Validation by enzyme expression analysis indicated that the chemotherapy-resistant prostate cancer stem cells were metabolically dormant with decreased fatty acid oxidation, methionine metabolism and ADP-ribosylation. Our results shed light on the pathways underlying the entry of cancer cells into dormancy that might contribute to the mechanisms of drug resistance.
MScanFit motor unit number estimation of abductor pollicis brevis: Findings from different experimental parameters

MScanFit motor unit number estimation (MUNE) based on the recording of the compound muscle action potential (CMAP) scan has wide applications. This study evaluated the effect of different CMAP scan settings on MScanFit MUNE. CMAP scan of the abductor pollicis brevis (APB) muscle was performed in 10 healthy subjects at a United States (US) research center using different stimulus pulse widths (0.1, 0.2 ms) and total number of stimuli or steps (500, 1,000), and in 12 healthy subjects at a China research center using a 0.1 ms pulse width and 500 steps. MScanFit MUNE was derived using the default model parameters. A significantly higher MUNE was obtained using the shorter than longer pulse width; 84.70 ± 21.56 (500 steps) and 77.90 ± 27.62 (1,000 steps) at a pulse width of 0.1 ms vs. 67.60 ± 18.72 (500 steps) and 62.20 ± 15.82 (1,000 steps) at a pulse width of 0.2 ms (p < 0.05). However, MUNE was unrelated to the number of steps (500 vs. 1,000, p > 0.1). MUNE was significantly higher in persons studied in the China center (136.42 ± 32.46) than the US center (84.70 ± 21.56) despite each center using the same pulse widths and steps (p < 0.001). After excluding the ethnicity, age and experimenter factors, this significant difference is speculated to be partly related to different electrode size used in the two centers. The findings suggest that CMAP scan experimental parameters should remain consistent, so the MScanFit MUNE will not be compromised by non-physiological factors.