Miracle-dz/UniFAR-FTUs huggingface dataset:
HIF-1α and VEGF levels for monitoring hepatocellular carcinoma treatment response to transcatheter arterial chemoembolization

Background: The purpose of the present study was to investigate the use of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) levels to monitor the treatment response to transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). Methods: A total of 41 consecutive HCC patients underwent TACE were enrolled into this study. The serum levels of HIF-1α and VEGF were measured using enzyme-linked immunosorbent assays (ELISAs) 1 day before, and 1, 7 and 28 days after TACE therapy. The overall tumor response was evaluated according to the modified Response Evaluation Criteria in Solid Tumors criteria. Patients with a complete response or partial response comprised the responding group, whereas those with stable disease or progressive disease comprised the non-responding group. The differences in serum HIF-1α and VEGF levels before and after TACE therapy were subjected to analysis of nonparametric test, while correlations between serum HIF-1α and VEGF levels were examined using Pearson’s correlation analysis. Receiver-operating characteristic (ROC) curve was applied to analyze the evaluation value of factors for the response of TACE on the treatment of HCC. P Results: In the present study, the serum levels of HIF-1α correlated positively with the serum levels of VEGF 1 day before TACE (r=0.546, P=0.000). The levels of HIF-1α and VEGF 1 day before, and 1, 7 and 28 days after TACE were significantly different, respectively (χ 2 =90.688, P=0.000 and χ 2 =45.585, P=0.000). The levels of the HIF-1α and VEGF increased markedly on day 1 and 7 after TACE and recovered to the pre-TACE level on day 28 after TACE. The levels of serum VEGF in responder group 28 days after TACE were significantly lower than those in non-responder group (Z=2.774, P=0.006), but the difference of HIF-1α levels between the two groups was not significant (Z=1.905, P=0.057). ROC curve analysis indicated that the sensitivity and specificity were 76.9% and 78.6%, when the threshold value was set at VEGF =254.5 pg/mL for predicting the response of TACE in patients with HCC; the corresponding area under the curve (AUC) was 0.772, respectively. Conclusions: The levels of both HIF-1α and VEGF in patients with HCC after TACE exhibit dynamic changes. However, HIF-1α and VEGF may be insufficient for predicting tumor response to TACE treatment.
Antioxidant activity and physicochemical properties of fresh, dried and infused herbal extract of Feijoa Fruit

In the present study fresh, dried and herbal infusion of feijo fruit (Feijoa sellowiana) were compared to their total phenol content, reducing power, DPPH and total antioxidant activity as well as different physicochemical characteristics. The study reveals that the physical characteristics of fruit, that is, color, texture and density were significantly affected by hot air drying. The chemical parameters of fruit determined, total soluble solid (TSS), acidity, pH, moisture, ash content, carbohydrate, protein, fat, ascorbic acid, total phenol, flavonoids and iodine content also evaluated as chemical characteristics. The results showed that the chemical and physicochemical characteristics are little affected by drying so with the various nutritional benefits, the fresh and dried fruits could be recommended for commercial exploitation and preparation of different value added products. Fresh fruit were found to be a good source of antioxidants and had the highest total phenol content, reducing power, DPPH and total antioxidant activity. A significant (p< 0.05) amount of antioxidants was lost after sun-drying of feijoa, whereas the herbal infusion of feijoa had the same total antioxidant activity with fresh fruit. These results suggest that all feijoa types serve as a good source of natural antioxidants and could potentially be considered as a functional food or functional food. [Sahar Kabiri, Farzad Gheibi, Maryam Joker, Shadi Basiri. Antioxidant activity and physicochemical properties of fresh, dried and infused herbal extract of Feijoa Fruit. Nat Sci 2016;14(12):64-70]. ISSN 1545-0740 (print); ISSN 2375-7167 (online). http://www.sciencepub. net/nature. 12. doi:10.7537/marsnsj141216.12.
Gene action of nutritional and quality traits in muskmelon (Cucumis melo L.)

A study of twenty one F1 hybrids of Muskmelon (Cucumis melo L.) in a half-diallel set involving seven parents showed over-dominance and low narrow-sense heritability for acidity, vitamin c, TSS, sodium, potassium, zinc, manganese, copper, iron, magnesium, calcium, respiration rate and ethylene emission rate. In all these characters, the dominance component of genetic variance (H1) was higher than the additive component of genetic variance (D) indicating predominance of dominant gene action over additive gene action and commercial exploitation of heterosis for improvement of these traits.
Neuropsychopharmacological Profiling of Flunarizine: A Calcium Channel Blocker

This study was designed to investigate the effect of flunarizine, a calcium channel blocker, a piperazine derivative in several neuropsychopharmacological experimental models. Effect of the drug flunarizine was evaluated in Pentobarbitone – induced sleeping time, Forced swim test, Actophotometer test, Elevated plus maze test for nootropic activity, Elevated plus maze for anxiety, Hole board test, Rotarod test, Apomorphine – induced stereotypy, Haloperidol – induced catalepsy and Pentylenetetrazole – induced convulsions using mouse as animal model. The result of this work provided evidences that flunarizine may be active as an anxiolytic agent and suggestive profile of atypical antipsychotic with a anticonvulsant activity. Flunarizine was found to produce alteration of general behavioural pattern, significant reduction in spontaneous locomotor activity, significant inhibition of stereotypic behavior induced by apomorphine (APM), significant increase in open arm entry – time spent in open arm without any alteration in the closed arm parameters, significant reduction in number of nose poking and line crossing in hole board apparatus, significant reduction in transfer latency (TL) in EPM, and a mild catalepsy at the highest dose among the selected doses for the study. Again a considerable decrease in immobility time in forced swim test was also observed which is not at par with the expected profile of flunarizine. Flunarizine also did not show any disturbances in motor co-ordination.
Correlation between Thyroid Dysfunction and Oxidative Stress in Undialyzed Chronic Renal Failure Patients

Background and Aim: Patients with chronic kidney disease (CKD) often have subclinical hypothyroidism. However, few reports have investigated changes in the status of subclinical hypothyroidism in CKD patients This study aimed to investigate the relationship between oxidative stress and thyroid hormones status in patients with chronic renal failure (CRF). Methods: Thyroid hormones and renal function parameters like serum urea, creatinine, and oxidative stress malandialdehyde (MDA) as oxidant and total vitamin-C as antioxidant were estimated and correlations between thyroid hormones, oxidative stress and renal function parameters were studied in 30 undialyzed chronic kidney disease patients’ verses 30 healthy controls. Results: We found both T3 and T4 were significantly reduced (p<0.05) whereas the serum TSH concentration was increased among those with CKD patient group compared to controls (p<0.05). We also observed that urea and creatinine were significantly increased among those with CKD patient than in the controls at (p<0.05) level. In addition, patients had lower total vitamin -c than the controls at (p<0.05) level, The MDA in the CKD patients was significantly increased than in the controls at (p<0.05) level. Conclusion: From our data, we concluded that renal insufficiency may lead to thyroid hormone disturbances and CKD appears to enhance the oxidative stress due increased uremia levels
Investigating Google Chrome 66.0.3359 Artefact: Internet Forensics Approach

: Evidence identification, extraction and analysis are crucial in the field of digital forensics and security at large. Evidence credibility, integrity and admissibility can help in deciding whether a criminal will be refuted or charged in a law court. One of the founts through which evidence is mined is Google chrome. Apart from Explorer, Edge, Firefox, Safari, Opera, UC Browser among many other browsers, Google chrome is one of the leading web browser versions which is compatible with many OS platforms including Android devices. Suspects can exploit web browsers in many ways, for instance by using them to collect information about their targets, to hide their crime as well as to search about new crime methods. Significantly, searching for artefacts left by browsing activities is significant in unearthing these activities. This research aims to establish forensic artefacts left by Google chrome web browser when using History Eraser version 4.8. 7.5 extension installed on Google Chrome version 66.0. 3359.181 running on Windows 10 operating system.
IRANIAN JOURNAL OF VETERINARY SURGERY

Pathology. Abstract ObjectiveBecause of the several differences between avian and mammalian physiology and anatomy, avian anesthesia requires to be more attentive. The aim of this study was to determine a safe injectable anesthetic agent that had more compatibility with the avian features. DesignExperimental study AnimalsTwelve male pigeons ProcedureThe pigeons weighing 302±35 g (mean ± SD) were divided into two groups (n=6). In group 1, midazolam (6 mg/kg,-IM) and in group 2, metamizole (500 mg/kg,-IM) were administrated as the pre-anesthetic agents and thereafter, propofol (8 mg/kg,-IV) was injected as the main anesthetic drug in both groups. The serum enzymatic changes were analyzed before and 1 hour after the last injection. Histopathological examinations of the liver and kidneys were also evaluated in terms of possible damages to the tissue. ResultsThe results of blood biochemistry evaluation in group 1 showed significant changes in the levels of AST and LDH before and after the injections (p<0.05). Histopathology results revealed significant changes in liver parameters in both groups. However, these changes were seen more prominent in group 1 (p<0.05). Also, none of the drugs of both groups had a negative impact on the kidney tissue (p>0.05). Conclusion and clinical relevanceBased on the results, metamizole and propofol combination showed that is safer than midazolam and propofol in terms of blood biochemical and histopathological evaluations and is more compatible with pigeons.
Time Improvement and Accuracy Enhancement in Detection and Rectification of Distorted Fingerprint Using PCA Algorithm

: One of the open come outs in unique mark affirmation is the absence of vigor against picture quality corruption. Low quality pictures result in presumptive and missing components, therefore debasing the execution of the general framework. Subsequently, it is critical for a unique finger impression affirmation framework to evaluate the quality and legitimacy of the caught unique mark pictures. Likewise the versatile contortion of fingerprints is one of the significant foundations for false non-match. While this issue affects all unique mark recognized applications, it is particularly hazardous in negative acknowledgment applications, for example, watch list and reduplication applications. In such applications, malevolent clients might intentionally mutilate their fingerprints to escape recognizable proof. In this paper, we proposed novel calculations to identify and correct skin mutilation taking into account an individual unique finger impression picture. Bending notice is seen as a two-class grouping issue, for which the enlisted edge introduction map and period guide of a unique mark are utilized as the component vector and a SVM classifier is readied to perform the characterization errand. Twisting correction (or proportionally contortion field estimation) is considered as a relapse issue, where the data utilized is a mutilated unique mark and the yield is the bending field. With a specific end goal to determine this issue, a database (known as reference database) of different mutilated reference fingerprints and comparing bending fields is inherent the disconnected from the net stage, and afterward in the on-line arrange, the closest neighbor of the info unique finger impression is experienced in the reference database and the relating contortion field is utilized to change the information twisted finger impression into an ordinary one.
The Possible Protective Role of Lemon Fruit Extract Against Cytogenetic Effects Induced by Cyclophosphamide in Male Albino Mice

The present study aims to evaluate the possible protective effect of lemon fruit extract (LFE) against DNA damage in bone marrow cells was evaluated using micronucleus assay of male mice treated with cyclophosphamide. To attain this aim the 18 male mice be divided into six groups: G1 control group, G2 male mice treated with LFE (10ml/kg /day orally), G3& G4 male mice treated with CP (10 & 20 mg/kg /day intraperitoneally), G5 & G6 male mice dually treated with LFE (10ml/kg/day orally) + CP (10 & 20 mg/kg /day intraperitoneally). All of the abovementioned groups were treated daily for 5 successive days. The micronucleus test showed that CP stimulates the production of micronucleus in polychromatic erythrocytes of bone marrow of treated mice giving evidence that CP is positive clastogen. While dual treatment with LFE and CP showed a reduction in the mean of polychromatic erythrocytes with micronucleus.Therefore, LFE could be concomitantly as a supplement to protect people undergoing chemotherapy. [Lina Abdul-Fattah Kurdi and Wejdan Saad Alamri. The Possible Protective Role of Lemon Fruit Extract Against Cytogenetic Effects Induced by Cyclophosphamide in Male Albino Mice. J Am Sci 2016;12(7):204-214]. ISSN 1545-1003 (print); ISSN 2375-7264 (online). http://www.jofamericanscience. org. 21. doi:10.7537/marsjas120716.21.
Determinants of Service Quality in Achieving Patient Satisfaction in University Malaya Medical Centre (UMMC)

Poster: "ECR 2014 / C-1387 / Determinants of Service Quality in Achieving Patient Satisfaction in University Malaya Medical Centre (UMMC)" by: "R. C. Eturajulu1, W. C. Steven Liew2, K. Rahmat3; 1Kuala Lumpur, Wilayah Persekutuan/MY, 2Selangor/MY, 3Kuala Lumpur/MY"
PHARMACOKINETICS, HEMATOLOGICAL AND BIOCHEMICAL EFFECTS OF CIPROFLOXACIN HYDROCHLORIDE-SODIUM CHOLATE COMPLEX

Objective: Ciprofloxacin is a broad spectrum antibiotic widely used in the treatment of infections, but its toxicological effects remains a great challenge. This research emphasized on analyzing the effect of a hydrophobic ion pair complex, involving ciprofloxacin hydrochloride and sodium cholate and also pegylated ciprofloxacin hydrochloride-sodium cholate complex. Methods: The effects of ciprofloxacin-cholate complex and pegylated ciprofloxacin-cholate complex were evaluated. LD50 was determined. The test drugs were orally to twenty-four albino mice, in six groups of four mice, at different doses of 7.14 mg/kg, 14.2 mg/kg and 21.4 mg/kg; and PEG complex, 7.14 and 14.2 mg/kg. Each was administered twice daily for fourteen days. The animal blood samples were subjected to hematological, biochemical tests; and the liver organs were collected. Histopathological examination was carried out on the harvested organs. Pharmacokinetic parameters were determined using the non-compartmental method. Results: The LD50 of the complex was above 5000 mg/kg. The non-significant decrease in PCV and WBC showed the parent drug and its complex are neither anemia inducing nor immunosuppressing; the significant decrease in the average RBCs count in post–treatment of 21.47 mg/kg of the complex could be from physiological changes; the bio-liver makers showed hepatocellular damage. Photomicrograph of the liver sections of mice showed mild areas of hepatocyte degeneration and inflammatory cell infiltrates. Conclusion: The biochemical, hematological and histology results showed complexation did not increase adverse effects of ciprofloxacin. The PEGYlated complex showed higher AUC and Cmax peak than the uncomplexed drug, hence more therapeutic benefits.
Estimation of genetic parameters for growth traits in Moghani sheep using random regression

The aim of this study was to estimate genetic parameters for body weight traits in Moghani sheep using random regression models. The Data were 19388 test day records collected from 6013 animals at JafarAbad plain research station located in Moghan, Ardebil province, from 1995 to 2009. The model used to analyze data included: year-season, birth year-season, sex, birth type and dam parity records as classified fixed effects and dams age at parturition and animals age as covariate variables. Random effects included in model were; direct additive genetic effect, maternal additive genetic effect, direct permanent environment effect and residual effect. Model 9 with 2th order of fit for genetic effects and 4th order of fit for permanent environment effect and with 21 parameters were considered as the most appropriate model. Residual effects were assumed heterogeneous between recording ages. Data analyzed by using of the DFREML software. Direct heritability for birth weight, 90, 180, 270 and 360 days of age were: 0.069, 0.002, 0.005, 0.013 and 0.021, respectively. These results showed that direct heritability reduced after birth and reached to the lowest amount in 90 days of age, but after that increased as the age increased. Maternal heritability had considerable reduction after birth and then increased as the age increased to 360. The weight of 270d and 360d had correlation which reduced as the distance between ages increased.
INVESTIGATING THE RELATIONSHIPBETWEEN FREE CASH FLOWSANDFIRM PERFORMANCE: EVIDENCEFROM TEHRAN STOCK EXCHANGE

In the present research, the relationship between free cash flows and the performance of firms listed in Tehran stock exchange is investigated. In particular, the goal of this study is to investigate the hypothesis of free cash flows. In this regard, one main hypothesis and four subordinate hypotheses are presented.63 firms are selected from listed firms in Tehran stock exchange during 7 years, from 2006 to 2012and tested. The methodology adopted here is a correlative regression and it aims at the pragmatic goals of the study. For testing the hypotheses, panel analysis for four factors were used: return on assets, return on equity ratio, Tobin’s Q ratio and stock return. The findings of statistical analysis of research hypotheses showed that there is a negative meaningful relationship between free cash flows with all evaluative factors of performance. In other words, the findings revealed an increase in the conflict of interests between managers and property owners due to free cash flows, which lead to decrease in the firm’s performance. So, the present research found evidence for proving free cash flows hypothesis in Tehran stock exchange.
SPEECH ENHANCEMENT USING HIDDEN MARVOK MODEL (HMM)

: Speech enhancement used for better communication system and removal of all degradations or unwanted background noises . The background noises can be babble noise, training noise, traffic noise. This paper proposes Hidden Markov Model (HMM) for speech enhancement. The proposed model is based upon the combination of the hidden markov model (HMM) with the non-negative matrix factorization (NMF). The supervised sparse non-negative matrix factorization (S-SNMF) has been used for the purpose of feature description from the given speech signal. The proposed model results have been obtained in the form of signal noise, signal to noise ratio and the signal log-likelihood ratio (before and after the speech signal enhancement procedure). The proposed model has been proved itself better in the terms of given resulting parameters.
Assessment of basic sanitation and its implication for disease control in Bayelsa state, Nigeria

Sanitation is fundamental to the health and general wellbeing of humans in every society. Unfortunately about 1.1 billion people who lack access to improved sanitation facility in the world practice open defaecation, resulting in approximately 2.4 deaths and 7% of total disease burden. This survey was carried out to assess the availability of improved facilities in three (3) rural communities of Bayelsa State, Nigeria in 2014. The specific objectives were to determine the sanitation coverage, methods of excreta disposal and commonly reported cases of excreta related diseases. A total of 260 households were randomly selected. The design for the study was descriptive cross sectional, with the use of random sampling, questionnaire survey, oral interview and observational checklist as the means of data collection. The Statistical Package for Social Sciences (SPSS) and Microsoft Excel version2.0 were employed for data analysis. The results were presented in frequency tables, bar charts, mean, percentages and chi square. The major findings were that 47% of the respondents interviewed had access to improved sanitation, while a larger proportion (50%) used unimproved sanitation facilities. The methods of excreta disposal adopted by the households were flush toilets used by (42%) of the respondents being the majority, followed by pit latrine (22%), open defaecation (16%), public/ communal toilets (8%) and 3% V.I. P utilization. The review of medical records at the primary health centres on prevalence of diseases revealed more malaria cases (37%), including typhoid fever (29%) and diarrhoea (12%) among the common excreta related diseases. Therefore, the study recommended urgent action by the government and all stakeholders to raise the level of awareness and increase the funding of sanitation projects to enable more people have improved excreta disposal facilities (sanitary toilets) and limit exposure or prevention of disease transmission in the state.
The Effects of some Herbal Essential Oils against Salmonella and Escherichia coli Isolated from Infected Broiler Flocks. J. World Poult. Res., 8 (3): 74-80

Escherichia coli and Salmonella spp are two bacterial infectious diseases responsible for heavy economic losses in the poultry industry. The emergence of antimicrobial resistance and its potential harmful threat to human health has led to a need to find safe alternatives for the control of these bacteria. To this end, the use of herbal remedies in poultry has been suggested. In this study, we have investigated the effect of essential oils extracted from five different herbal plants against Salmonella spp and Escherichia coli that have been isolated directly from infected broiler flocks. Standard Disk-diffusion method, Minimum Inhibition Concentration and minimum bactericidal concentration were used to determine the inhibitory effect of these essential oils. Also, tetracycline was used as a control group. Among the essential oils, Carum copticum had the highest antibacterial properties. The maximum inhibition zone in diameter against Salmonella and Escherichia coli were respectively 26.7 and 22.5 mm that concern about Carum copticum essential oils. According to the results of this study, it was found that some of the essential oils have a stronger antibacterial effect than tetracycline. So, after the complementary studies, some of these herbal plants can be suggested as alternatives to antibiotics for treating infections caused by these bacteria in poultry industry.