Miracle-dz/UniFAR-FTUs huggingface dataset:
Individuals with Psychopathic Traits and Poor Attitudes towards Animals Can Recognise Infant Features But Give Them Reduced Attentional Priority

Simple Summary Certain facial characteristics in companion animals are perceived by humans as being ‘cute’. This includes having large eyes, a round head and a small nose and mouth. These characteristics, which are shared with human infants, trigger care-giving responses in humans. Despite this, however, companion animal abuse occurs. The aim of this research was to better understand cognitive processes of people with pro-social personality traits and positive attitudes towards animals compared to those with anti-social personality traits and negative attitudes towards animals. This was done by assessing participants’ ability to detect cues of cuteness in animal and human infant faces (study 1) and by assessing attention to cuteness cues via an eye-tracking task (study 2). Findings indicate that the ability to detect cuteness cues is widespread, regardless of personality or attitudes. However, individuals with anti-social personality traits and negative attitudes towards animals chose to pay less attention to ‘cute’ stimuli in the eye-tracking task. This proof of concept study is an initial step in determining how individuals ‘at risk’ of committing animal abuse process information on infant features in animals. Abstract Infant features are physical traits that are characteristic of human infants and include facial features such as large and low-lying eyes, and a small nose and mouth. Animals possessing high levels of infant features elicit care-giving responses in humans. Despite this, animal cruelty is a common occurrence. The aim of this research was to determine whether the ability to recognise and/or attend to infant features is linked to subclinical psychopathic traits and attitudes towards animals. Using a community sample, participants (n = 387) completed a cuteness forced-choice task. Self-reported psychopathy and attitude towards animals were not related to the participants’ ability to detect cues of cuteness in human infants and animals. In a second study, participants (n = 142) were screened for low versus high primary psychopathy and low versus high animal attitude scores. A Psychopathy-Attitude Composite score was created and a subset of participants (n = 50) from the upper and lower quartiles completed a free-viewing eye-tracking task where ‘Cute’, ‘Neutral, ‘Monetary’ and ‘Control’ images were presented in pairs. Higher levels of psychopathic traits and an anti-animal welfare attitude were associated with decreased attention to ‘Cute’ images in terms of decreased dwell time, mean fixation duration and mean fixation count, measures of voluntary attention. There were a number of interactions between Psychopathy-Attitude Composite classification and attention to each image category in terms of dwell time, first fixation duration, mean fixation duration and fixation count. These findings support the theory that individuals with psychopathic traits recognise facial cues of vulnerability but choose to give them reduced attentional priority. This may have implications for animal welfare.
Correlation between expression levels of lncRNA UCA1 and miR-18a with prognosis of hepatocellular cancer.

OBJECTIVE To uncover the prognostic potentials of long non-coding RNA (lncRNA) UCA1 and miR-18a in hepatocellular cancer (HCC). PATIENTS AND METHODS Expression levels of UCA1 and microRNA-18a (miR-18a) in HCC tissues and adjacent normal ones harvested from 55 HCC patients were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Clinical data of HCC patients were recorded, including pathological grading, tumor staging, intrahepatic metastasis, serum level of α-fetoprotein (AFP), tumor size, tumor number, recurrence, etc. Based on the median levels of UCA1 and miR-18a, enrolled HCC patients were classified into high-level and low-level group. Potential correlation between expression levels of UCA1 and miR-18a with survival of HCC patients was analyzed. The 5-year follow-up data of HCC patients were collected for analyzing factors that may influence prognosis in HCC patients by the Cox regression model. RESULTS UCA1 was upregulated and miR-18a was downregulated in HCC tissues. HCC patients with stage III-IV, tumor size ≥5 cm or multiple tumors expressed high level of UCA1. Besides, HCC patients with stage I-II, non-intrahepatic metastasis or primarily diagnosed expressed a relatively low level of miR-18a. High-level UCA1 and low-level miR-18a predicted worse prognosis in HCC patients. Cox regression analysis revealed that tumor node metastasis (TNM) staging, intrahepatic metastases, postoperative recurrences, and UCA1 were risk factors for HCC, while miR-18a was the protective factor. CONCLUSIONS LncRNA UCA1 is upregulated and miR-18a is downregulated in HCC tissues. High-level UCA1 and low-level miR-18a are closely linked to poor prognosis in HCC.
Dystonia‐ataxia syndrome with permanent torsional nystagmus caused by ECHS1 deficiency

Biallelic mutations in ECHS1, encoding the mitochondrial enoyl‐CoA hydratase, have been associated with mitochondrial encephalopathies with basal ganglia involvement. Here, we describe a novel clinical presentation consisting of dystonia‐ataxia syndrome with hearing loss and a peculiar torsional nystagmus observed in two adult siblings. The presence of a 0.9‐ppm peak at MR spectroscopy analysis suggested the accumulation of branched‐chain amino acids. Exome sequencing in index probands identified two ECHS1 mutations, one of which was novel (p.V82L). ECHS1 protein levels and residual activities were reduced in patients’ fibroblasts. This paper expands the phenotypic spectrum observed in patients with impaired valine catabolism.
Effect of Sleeve Gastrectomy on Bone Metabolism and Serum 5-Hydroxytryptamine in Obese Rats

Background Studies have shown that bariatric surgery, such as sleeve gastrectomy (SG), has an adverse effect on bone, including decreased bone mineral density (BMD) and bone metabolism. Peripheral 5-hydroxytryptamine (5-HT) has an adverse regulatory effect on bone formation. Here, we assessed changes in bone metabolism and whether 5-HT is involved in the effect of SG on bone metabolism. Material/Methods A rat model of obesity was established using Wistar rats. After successful modeling, rats were randomly assigned to 2 groups – the SG group and the Sham group – with 10 rats in each group. We then performed sleeve gastrectomy or sham operation. Bone metabolic markers and BMD of rats were measured at 2 and 16 weeks after the operation and the level of 5-HT in serum was determined. Rats were killed at 16 weeks after the operation, and bones of the hind limbs were harvested to measure 5-HT by immunofluorescence. Results BMD was decreased and bone metabolism demonstrated a trend of bone destruction in the rats after SG. A significantly increasing trend in the level of serum 5-HT was found, and bone immunofluorescence showed increased expression of 5-HT. Conclusions BMD was decrease and bone metabolism demonstrated a trend of bone destruction after SG. SG can affect the level of 5-HT in serum or bone tissue and the 5-HT may be involved in the process through which SG affects bone metabolism.
Criteria to assess tongue strength for predicting penetration and aspiration in patients with stroke having dysphagia.

BACKGROUND Instrumental assessments are typically used to assess swallowing function in stroke patients with dysphagia, but these tests cannot be used for all patients or for continuous monitoring. Hence, an adjunctive method is necessary for screening patients who may require such tests. AIM The purpose of this study was to analyze tongue strength with respect to the presence or absence of penetration and aspiration, using instrumental assessments, to provide a basis for clinical decision-making. DESIGN Prospective observational study. SETTING University Hospitals in Gwangju, Korea. POPULATION Seventy-nine subjects with dysphagia underwent video fluoroscopic swallowing study (VFSS) and Iowa Oral Performance Instrument evaluations. METHODS VFSS results were assessed for the presence of penetration and aspiration, according to the penetration-aspiration scale. Receiver operating characteristic curve analysis was conducted with tongue strengths based on penetration and aspiration. RESULTS During the swallowing of pureed, liquid, and solid foods, cut-off values of tongue strength for the anterior and posterior elevation and for the protrusion of tongue were suggested in cases of penetration and aspiration, among patients with dysphagia. These criteria had positive and negative predictive values of 54.6-90.2% and 57.5-96.9%, respectively. CONCLUSIONS This study found that tongue strength has predictive abilities similar to clinical and bedside tests to screen penetration and aspiration in stroke patients with swallowing disorders. Therefore, it is a new screening test that clinical practitioners can choose to reduce the risk of pneumonia caused by post-stroke disorders. CLINICAL REHABILITATION IMPACT As a new screening tool, tongue strength can be combined with other clinical and instrumental assessments to predict penetration and aspiration in stroke patients with dysphagia.
A Lightweight and Low-Power UAV-Borne Ground Penetrating Radar Design for Landmine Detection

This paper presents the development of a lightweight and low-power Ground Penetrating Radar (GPR) to detect buried landmines in harsh terrain, using an Unmanned Aerial Vehicle (UAV). Despite the fact that GPR airborne systems have been already used for a while, there has yet been no focus on the UAV autonomy, which depends on the payload itself. Therefore, the contribution of this work is the introduction of a lightweight and low-power consumption GPR system, which is based on the Stepped Frequency Continuous Wave (SFCW) radar principle. The Radio Frequency (RF) transceiver represents an improved implementation of the super-heterodyne architecture, which currently offers higher sensitivity. This is achieved by combining analog and digital processing techniques. The experimental results showed that the developed system can detect both metallic and plastic buried targets. Target detection with a scanning height up to about 0.5 m shows good applicability in an unstructured, harsh environment, which is typical of mined terrain. The proposed system still needs some improvements for a fully operational system regarding different aspects of scanning speeds and soil properties such as moisture content.
Contribution of street food to dietary intake of habitual urban consumers: A cross-sectional study in Kampala city, Uganda

Background: Street food has continued to be a popular food source in the urban settings of developing countries and is proving to be a vital urban dietary source. However, its dietary contribution among urban populations is yet to be comprehensively understood. Aim: To assess how street food contributes to the dietary intake of habitual street food consumers. Methods: We conducted a community-based cross-sectional study among habitual street food consumers in Kampala city. We defined habitual intake as consumption of a serving of any street food for ≥2 days/week regardless of the food group and number of times it was consumed in a particular day. Questionnaires were used to capture quantitative data on sociodemographic characteristics, anthropometry, 24-hour diet intake and 2-month street food consumption frequency. The Nutritics® diet analysis software version 4.3 and STATA version 13.0 were used for nutrient and statistical analyses respectively. Results: Street food contributed considerably to the daily intake of fat (49.1%), sodium (38.4%) and calcium (36.5%) and least towards the daily intake of vitamin A (11.3%). The majority of consumers opted for street food at breakfast (50%) whereas lunch and snacks featured the least for overall street food inclusion (all 20%). Overall, men demonstrated more dietary intake and inclusion at meals from street food than women. Conclusions: This study indicates a significant contribution of street food for urban consumers but men derive more benefit than women in terms of nutrient intake and inclusion of street food in meals.
Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins

Gaining a fundamental insight into the biomolecular recognition of posttranslationally modified histones by epigenetic reader proteins is of crucial importance to understanding the regulation of the activity of human genes. Here, we seek to establish whether trimethylthialysine, a simple trimethyllysine analogue generated through cysteine alkylation, is a good trimethyllysine mimic for studies on molecular recognition by reader proteins. Histone peptides bearing trimethylthialysine and trimethyllysine were examined for binding with five human reader proteins employing a combination of thermodynamic analyses, molecular dynamics simulations and quantum chemical analyses. Collectively, our experimental and computational findings reveal that trimethylthialysine and trimethyllysine exhibit very similar binding characteristics for the association with human reader proteins, thereby justifying the use of trimethylthialysine for studies aimed at dissecting the origin of biomolecular recognition in epigenetic processes that play important roles in human health and disease.
Mechanisms of OCT4-SOX2 motif readout on nucleosomes

Engaging the nucleosome Cell identity is defined by gene expression patterns that are established through the binding of specific transcription factors. However, nucleosomal units limit access of transcription factors to specific DNA motifs within the mammalian genome. To study how transcription factors bind such chromatinized, nucleosome-embedded motifs, Michael et al. focused on the pluripotency factors OCT4 and SOX2. They systematically quantified the relative affinities of these factors at different motif positions throughout the nucleosome, enabling structure determination of OCT4-SOX2–bound nucleosomes by cryo–electron microscopy. OCT4 and SOX2 bound cooperatively to strengthen DNA-binding affinity and resulted in DNA distortions that destabilized the nucleosome. This analysis reveals position-dependent binding modes that were validated in vivo, providing insights on how transcription factors read out chromatinized motifs. Science, this issue p. 1460 Site-specific nucleosome engagement by pluripotency factors reveals how transcription factors distort nucleosomes at chromatinized motifs. Transcription factors (TFs) regulate gene expression through chromatin where nucleosomes restrict DNA access. To study how TFs bind nucleosome-occupied motifs, we focused on the reprogramming factors OCT4 and SOX2 in mouse embryonic stem cells. We determined TF engagement throughout a nucleosome at base-pair resolution in vitro, enabling structure determination by cryo–electron microscopy at two preferred positions. Depending on motif location, OCT4 and SOX2 differentially distort nucleosomal DNA. At one position, OCT4-SOX2 removes DNA from histone H2A and histone H3; however, at an inverted motif, the TFs only induce local DNA distortions. OCT4 uses one of its two DNA-binding domains to engage DNA in both structures, reading out a partial motif. These findings explain site-specific nucleosome engagement by the pluripotency factors OCT4 and SOX2, and they reveal how TFs distort nucleosomes to access chromatinized motifs.
Cerebrospinal fluid gusher in cochlear implant and its associated factors

Abstract Introduction: Cochlear implants (CI) is considered a safe procedure with overall complication rate of 12.5% amongst adult and pediatric population. Cerebrospinal fluid (CSF) gusher is regarded as a common CI intraoperative complication. Objective: In this study, we determined the association between probable associated factors and occurrence of intraoperative CSF gusher. Method: In a retrospective survey, 394 patients with severe to profound sensorineural hearing loss who underwent primary cochlear implantation surgery were evaluated. Patients with incomplete electronic or manual file and those with revision, explantation or reimplantation surgery were excluded. Result: three hundred and ninety-four CI patients with a mean age of 8.74 ± 12.21 years were reviewed 49.62% of them were female. CSF gusher developed in 22 patients (5.58%). Patients with CSF gusher had more structural abnormalities in their CT scans’ report. Common cavity malformation and Mondini dysplasia were the most common abnormal reports amongst those with intra-operative CSF gusher. Conclusion: In conclusion, cochlea structural abnormalities affect the incidence of CSF gusher in CI recipients. Common cavity malformation and Mondini dysplasia were associated with an increased incidence of CSF gusher. We insist on more precise pre-operative imaging of those with abnormal cochlea structures to provide the needed management.
Comparative Transcriptomic Analysis of Subcutaneous Adipose Tissue from Local Pig Breeds

When compared to modern lean-type breeds, Portuguese local Alentejano (AL) and Bísaro (BI) pig breeds present a high potential for subcutaneous and intramuscular fat (IMF) deposition which contributes for better meat quality. The aim of this work was to explore the genome function to better understand the underlying physiological mechanisms associated with body fat accretion. Dorsal subcutaneous fat samples were collected at slaughter from adult animals (n = 4 for each breed) with ~150 kg body weight. Total RNA was obtained and sequenced for transcriptome analysis using DESeq2. A total of 458 differentially expressed (DE) genes (q-value < 0.05) were identified, with 263 overexpressed in AL and 195 in BI. Key genes involved in de novo fatty acid biosynthesis, elongation and desaturation were upregulated in AL such as ACLY, FASN, ME1, ELOVL6 and SCD. A functional enrichment analysis of the DE genes was performed using Ingenuity Pathway Analysis. Cholesterol synthesis is suggested to be higher in AL via SREBF2, SCAP and PPARG, while lipolytic activity may be more active in BI through GH and AMPK signalling. Increased signalling of CD40 together with the predicted activation of INSIG1 and INSIG2 in BI suggests that this breed is more sensitive to insulin whereas the AL is less sensitive like the Iberian breed.
Direct and Indirect Effects of Neuroticism on Internet Addiction in College Students: A Structure Equation Modeling Analysis

In the recent decade, increased severity of Internet addiction has been the focus of considerable attention. This research aimed to explore the relationships between neuroticism and Internet addiction. A total of 459 undergraduate students in China participating in this study completed self-report measures of neuroticism, impulsivity, and Internet addiction. The results showed that neuroticism, impulsivity, and Internet addiction were significantly and positively correlated with one other. The structural equation modeling approach indicated that impulsivity, in part, mediated the effect of neuroticism on Internet addiction. An important indirect path from neuroticism to Internet addiction through impulsivity was exposed using the bootstrap method. The outcomes of previous studies were expounded on to define how neuroticism affects Internet addiction.
Ultrafast optoelectronic processes in 1D radial van der Waals heterostructures: carbon, boron nitride and MoS2 nanotubes with coexisting excitons and highly mobile charges.

Heterostructures built from 2D, atomically-thin crystals are bound by the van der Waals force, and exhibit unique optoelectronic properties. Here, we report the structure, composition and optoelectronic properties of 1D van der Waals heterostructures comprising carbon nanotubes wrapped by atomically-thin nanotubes of boron nitride and molybdenum disulfide (MoS2). The high quality of the composite was directly evidenced on the atomic scale by transmission electron microscopy, and on the macroscopic scale by a study of the heterostructure's equilibrium and ultrafast optoelectronics. Ultrafast pump-probe spectroscopy across the visible and terahertz frequency ranges identified that, in the MoS2 nanotubes, excitons coexisted with a prominent population of free charges. The electron mobility was comparable to that found in high-quality atomically-thin crystals. The high mobility of the MoS2 nanotubes highlights the potential of 1D van der Waals heterostructures for nanoscale optoelectronic devices.
Eco-Physiological Screening of Different Tomato Genotypes in Response to High Temperatures: A Combined Field-to-Laboratory Approach

High temperatures represent a limitation for growth and development of many crop species. Several studies have demonstrated that the yield reduction of tomato under high temperatures and drought is mainly due to a photosynthetic decline. In this paper, a set of 15 tomato genotypes were screened for tolerance to elevated temperatures by cultivating plants under plastic walk-in tunnels. To assess the potential tolerance of tomato genotypes to high temperatures, measurements of chlorophyll fluorescence, pigments content and leaf functional traits have been carried out together with the evaluation of the final yields. Based on the greenhouse trials, a group of eight putative heat-sensitive and heat-tolerant tomato genotypes was selected for laboratory experiments aimed at investigating the effects of short-term high temperatures treatments in controlled conditions. The chlorophyll fluorescence induction kinetics were recorded on detached leaves treated for 60 min at 35 °C or at 45 °C. The last treatment significantly affected the photosystem II (PSII) photochemical efficiency (namely maximum PSII quantum efficiency, Fv/Fm, and quantum yield of PSII electron transport, ΦPSII) and the non-photochemical quenching (NPQ) in the majority of genotypes. The short-term heat shock treatments also led to significant differences in the shape of the slow Kautsky kinetics and its significant time points (chlorophyll fluorescence levels minimum O, peak P, semi-steady state S, maximum M, terminal steady state T) compared to the control, demonstrating heat shock-induced changes in PSII functionality. Genotypes potentially tolerant to high temperatures have been identified. Our findings support the idea that chlorophyll fluorescence parameters (i.e., ΦPSII or NPQ) and some leaf functional traits may be used as a tool to detect high temperatures-tolerant tomato cultivars.