Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute MRI predictors of chronic motor function and tissue sparing in rat cervical spinal cord Injury.

Predicting functional outcomes from spinal cord injury (SCI) at the acute setting is important for patient management. This work investigated the relationship of early magnetic resonance imaging (MRI) biomarkers in a rat model of cervical contusion SCI with long-term functional outcome and tissue-sparing. Forty rats with contusion injury at C5 at either the spinal cord midline (bilateral) or over the lateral cord (unilateral) were examined using in vivo multimodal quantitative MRI at 1 day post injury. The extent of T2-weighted hyperintensity reflecting edema was greater in the bilateral model compared to the unilateral injury. Diffusion tensor imaging (DTI) exhibited microscopic damage in similar regions of the cord as reductions in fractional anisotropy (FA) and mean diffusivity (MD), but DTI parameter maps were also confounded by the presence of vasogenic edema which locally increased FA and MD. In comparison, filtered diffusion weighted imaging more clearly delineated the location of acute axonal damage without effects of vasogenic edema. Pairwise correlation analysis revealed that 28-day motor functional outcomes were most strongly associated with the extent of edema (R= -0.69). Principal component analysis identified close associations of motor functional score with tissue sparing, the extent of edema, lesion area and injury type (uni or bilateral). Among the diffusion MRI parameters, lesion areas measured with fDWI had the strongest association with functional outcome (R= -0.41). Voxelwise correlation analysis identified a locus of white matter damage associated with function in the dorsal white matter, although this was likely driven by variance across the two injury patterns (uni- and bilateral injury). Nonetheless, correlation with motor function within the damaged region found in the voxelwise analysis outperformed morphological lesion area measurement as a predictor of chronic function. Collectively, this study characterized anatomic and diffusion MRI signatures of acute SCI at cervical spine and their association with chronic functional outcomes and histologic results.
Hyperhidrosis in sleep disorders – A narrative review of mechanisms and clinical significance

Hyperhidrosis is characterized by excessive sweating beyond thermoregulatory needs that affects patients' quality of life. It results from an excessive stimulation of eccrine sweat glands in the skin by the sympathetic nervous system. Hyperhidrosis may be primary or secondary to an underlying cause. Nocturnal hyperhidrosis is associated with different sleep disorders, such as obstructive sleep apnea, insomnia, restless legs syndrome/periodic limb movement during sleep and narcolepsy. The major cause of the hyperhidrosis is sympathetic overactivity and, in the case of narcolepsy type 1, orexin deficiency may also contribute. In this narrative review, we will provide an outline of the possible mechanisms underlying sudomotor dysfunction and the resulting nocturnal hyperhidrosis in these different sleep disorders and explore its clinical relevance.
Should We Perform Incidental Appendectomy in Trauma Patients Undergoing Laparotomy?

Incidental appendectomy (IA) is sometimes performed in patients undergoing abdominal operations to prevent subsequent development of appendicitis. Patients who undergo laparotomy for major abdominal trauma are at high risk of developing dense adhesions, increasing the risk of future operations. Therefore, there is a potential benefit to IA for patients undergoing trauma laparotomy. We performed a retrospective review of patients who underwent IA during laparotomy for abdominal trauma at a Level 1 trauma center between January 2010, and June 2020. Twenty-three patients underwent IA; they tended to be young (33.7 ± 18.9 years) and male (87%) with 12 penetrating and 11 blunt injuries. Regarding indications, 13 had no documented intra-operative abnormalities of the appendix, 6 patients had a fecalith, and 3 had trauma to the appendix. One patient’s appendix was adhered to the peritoneum and one patient had unusual anatomic location. Only one patient developed an appendiceal stump leak after IA.
An examination of machine learning to map non‐preference based patient reported outcome measures to health state utility values

Abstract Non‐preference‐based patient‐reported outcome measures (PROMs) are popular in health outcomes research. These measures, however, cannot be used to estimate health state utilities, limiting their usefulness for economic evaluations. Mapping PROMs to a multi‐attribute utility instrument is one solution. While mapping is commonly conducted using econometric techniques, failing to specify the complex interactions between variables may lead to inaccurate prediction of utilities, resulting in inaccurate estimates of cost‐effectiveness and suboptimal funding decisions. These issues can be addressed using machine learning. This paper evaluates the use of machine learning as a mapping tool. We adopt a comprehensive approach to compare six machine learning techniques with eight econometric techniques to map the Patient‐Reported Outcomes Measurement Information System Global Health 10 (PROMIS‐GH10) to the EuroQol five dimensions (EQ‐5D‐5L). Using data collected from 2015 Australians, we find the least absolute shrinkage and selection operator (LASSO) model out‐performed all machine learning techniques and the adjusted limited dependent variable mixture model (ALDVMM) out‐performed all econometric techniques, with the LASSO performing better than ALDVMM. The variable selection feature of LASSO was then used to enhance the performance of the ALDVMM in a hybrid model. Our analysis identifies the potential benefits and challenges of using machine learning techniques for mapping and offers important insights for future research.
Comparative assessment of cognitive impairment and oxidative stress markers among vitamin D insufficient elderly patients with and without type 2 diabetes mellitus (T2DM)

Background Disorders of mental health are known to affect cognitive functions, hence called as cognitive disorders. Impaired glucose metabolism, insulin resistance, vitamin-D deficiency and oxidative stress are some of the key early events reported to be involved in the pathogenesis of most common cognitive disorders, which include Alzheimer’s disease. Type-2 diabetes mellitus (T2DM) is one of the known contributing factors of cognitive impairment and dementia. Methods A cross sectional study was carried out in 145 subjects, who were assessed for cognitive function by modified mini mental status examination (3MS). In addition, measurement of fasting blood sugar (FBS), fasting insulin, HbA1c, lipid profile, vitamin D and oxidative markers was performed. Participants were divided into different groups based on (a) vitamin D insufficiency and sufficiency; (b) diabetic and non-diabetic with and without cognitive impairment. Results The study included a total of 145 subjects; 51 males and 94 females and the mean age was 68.24±9.70 years. Among diabetics with vitamin D insufficiency, 35 subjects (71.43%) had cognitive impairment, but, among non-diabetics with vitamin D insufficiency, 27 subjects (62.79%) had cognitive impairment. Chi square test showed no significant association between diabetes, vitamin D insufficiency and cognitive impairment. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels were non-significantly lower in cognition-impaired subjects, when compared to cognition normal subjects in diabetics with vitamin D insufficiency. Conclusion Our study showed that cognitive impairment is more predominant in individuals with diabetes. However, our study did not find any significant relationship between T2DM, vitamin D deficiency, cognitive impairment, and oxidative stress. A significant association was found only with GPx and 3MSE score in vitamin D insufficient non-diabetics.
Assessing Patients' Attitudes towards Telepsychotherapy: The Development of the Unified Theory of Acceptance and Use of Technology -Patient Version.

This study presents the development of a self-report measure of patients' attitudes towards telepsychotherapy. The measure is based on a well-researched model of attitudes towards using technology, the Unified Theory of Acceptance and Use of Technology (UTAUT) framework (Venkatesh et al., 2003). We examined the psychometric properties of the UTAUT adapted for psychotherapy patients (UTAUT-P) in a sample of 107 psychotherapy patients who received telepsychotherapy via videoconferencing during the COVID-19 pandemic. Exploratory factor analysis resulted in a 14-item UTAUT-P version, with four factors; 1) Therapy Quality Expectancy, 2) Convenience, 3) Ease of Use, and 4) Pressure from Others, and was further corroborated by the results of the confirmatory factor analysis. Our results indicated the four-factor model's adequate fit to the data and demonstrated adequate construct validity and reliability of the UTAUT-P factors. All factors, except for Ease of Use, were significantly and positively associated with intention to use telepsychotherapy technology in the future. This study complements the research on therapists' attitudes towards telepsychotherapy, based on the therapist version of the UTAUT. The developed 14-item UTAUT-P might be a helpful, brief self-report tool in clinical practice, which might give the patient a voice around the potential use of telepsychotherapy technology in their care. This initial application of the UTAUT-P patients during the COVID-19 pandemic offers a building block for future research on patients' attitudes towards telepsychotherapy, outside the context of a forced transition.
One-year safety and tolerability of tezepelumab in Japanese patients with severe uncontrolled asthma: results of the NOZOMI study

Abstract Objective To assess the long-term safety of tezepelumab in Japanese patients with severe uncontrolled asthma. Methods This phase III, 52-week, open-label, single-arm study (NOZOMI, NCT04048343) evaluated the safety/tolerability of subcutaneous (SC) tezepelumab 210 mg every 4 weeks (Q4W) in Japanese patients aged 12–80 years with severe uncontrolled asthma using medium- to high-dose inhaled corticosteroids and at least one additional asthma controller medication, with/without oral corticosteroids. Exploratory outcomes included efficacy (asthma exacerbations, lung function, and asthma control), pharmacokinetic parameters, and immunogenicity. Results Among 65 patients (median age 52 years), 39 (60%) experienced 94 adverse events (AEs; predominantly nasopharyngitis [13/65]) of mild (49.2%), moderate (7.7%), or severe (3.1%) intensity. Two patients had transient injection site erythema related to tezepelumab. Four patients reported serious AEs unrelated to tezepelumab and one AE led to treatment discontinuation. AEs of special interest were infrequent and generally mild/moderate. Apart from a decrease in blood eosinophils (an expected pharmacodynamic effect), no notable trends/clinically relevant changes in hematology, clinical chemistry, or urinalysis parameters were observed. Among exploratory outcomes, tezepelumab was associated with a low annualized asthma exacerbation rate over the study period (0.11/patient-year), improved lung function (mean [standard deviation] change from baseline of 0.075 [0.226] L in pre-dose/pre-bronchodilator forced expiratory volume in 1 s), and better asthma control versus baseline (responder rate: 71.4% at Week 52). Conclusion Tezepelumab 210 mg SC Q4W in Japanese patients with severe uncontrolled asthma showed safety/tolerability profiles similar to international data, with low exacerbation rates and improvements in lung function and asthma control.
Measuring the Impact of the Trans-European Road Transport Network on the Accessibility of European Urban Agglomerations

Transport infrastructure investment is a catalyst for enhanced competitiveness and economic growth through an overall reduction in travel times and costs. These efficiency gains are among the goals of the Trans-European Transport Network (TEN-T) program, one of the major European Union infrastructure policy packages. This study evaluated the benefits of TEN-T with respect to increased accessibility for the population that it encompassed and by using a detailed and up-to-date representation of the entire European road network. A routing algorithm that could efficiently exploit the high detail of the road network was used. By considering various impedance functions in outreach opportunities, the proposed methodology compared, for all major European urban agglomerations considered (695 in total), two measures of accessibility: one baseline measure that considered the TEN-T network as implemented in 2014 and one scenario measure that considered that the whole TEN-T network was completed. The proposed methodology addressed self-accessibility by considering a weighted travel time of the entire road network within each urban agglomeration under study. The results show where the major benefits (accessibility gains) are expected to occur following the completion of the TEN-T policy. In general, the main positive effects are to appear in European areas that are lagging behind in infrastructure investment (Eastern Europe) and in their neighboring counterparts (Central Europe). The presented quantitative estimates may be useful for an eventual review of the focus of and priority for the not-yet-implemented part of TEN-T policy.
Measuring gender attitudes: Developing and testing Implicit Association Tests for adolescents in India

We develop and test gender attitude measures conducted with a school-based sample of adolescents aged 14–17 years in India. We test a measure with survey items and vignettes to capture gender-based value and stereotypes, an Implicit Association Test (IAT) capturing gender-based value, and an IAT capturing gender stereotype. All demonstrate good internal reliability, and both IATs are significantly associated with our survey measure suggesting criterion validity, though not confirming it due to the lack of a gold standard measure on gender attitudes. Finally, construct validity is indicated from the measures’ positive significant associations with higher girls’ mobility and education. The gender-related IAT tools developed are consistent and valid, and modestly correlated with gender-related behavior outcomes such as mobility and school enrolment.
Novel small synthetic HIV-1 V3 crown variants: CCR5 targeting ligands

Abstract The CC chemokine receptor 5 (CCR5) antagonism represents a promising pharmacological strategy for therapeutic intervention as it plays a significant role in reducing the severity and progression of a wide range of pathological conditions. Here we designed and generated peptide ligands targeting the chemokine receptor, CCR5, that were derived from the critical interaction sites of the V3 crown domain of envelope protein glycoprotein gp120 (TRKSIHIGPGRAFYTTGEI) of HIV-1 using computational biology approach and the peptide sequence corresponding to this region was taken as the template peptide, designated as TMP-1. The peptide variants were synthesized by employing Fmoc chemistry using polymer support and were labelled with rhodamine B to study their interaction with the CCR5 receptor expressed on various cells. TMP-1 and TMP-2 were selected as the high-affinity ligands from in vitro receptor-binding assays. Specific receptor-binding experiments in activated peripheral blood mononuclear cells and HOS.CCR5 cells indicated that TMP-1 and TMP-2 had significant CCR5 specificity. Further, the functional analysis of TMP peptides using chemotactic migration assay showed that both peptides did not mediate the migration of responsive cells. Thus, template TMP-1 and TMP-2 represent promising CCR5 targeting peptide candidates.
Detection of changes in synaptic density in amyotrophic lateral sclerosis patients using 18F‐SynVesT‐1 positron emission tomography

Synaptic loss is well established as the major correlate of characteristic and consistent pathology in amyotrophic lateral sclerosis (ALS). We aimed to assess the possible discriminant diagnostic value of 18F‐SynVesT‐1 positron emission tomography (PET) as a marker of ALS pathology and investigate whether specific synaptic density signatures are present in ALS with different subtypes.
The Fusion-Secure Base Hypothesis

Identity fusion is traditionally conceptualized as innately parochial, with fused actors motivated to commit acts of violence on out-groups. However, fusion’s aggressive outcomes are largely conditional on threat perception, with its effect on benign intergroup relationships underexplored. The present article outlines the fusion-secure base hypothesis, which argues that fusion may engender cooperative relationships with out-groups in the absence of out-group threat. Fusion is characterized by four principles, each of which allows a fused group to function as a secure base in which in-group members feel safe, agentic, and supported. This elicits a secure base schema, which increases the likelihood of fused actors interacting with out-groups and forming cooperative, reciprocal relationships. Out-group threat remains an important moderator, with its presence “flipping the switch” in fused actors and promoting a willingness to violently protect the group even at significant personal cost. Suggestions for future research are explored, including pathways to intergroup fusion.
Comparative study of laser flare photometry versus slit-lamp cell measurement in pediatric chronic non-infectious anterior uveitis

Purpose To evaluate the role of laser flare photometry (LFP) for monitoring the course of intraocular inflammation in children with chronic anterior uveitis. Methods Seventy-six eyes of 43 children with non-infectious chronic anterior uveitis were reviewed retrospectively. Results The median follow-up was 48.6 ± 23.1 months. Patients on immunosuppressive treatment at last follow-up, showed significantly higher flare values than patients who discontinued treatment (20.47 ± 15.49 vs. 6.33 ± 4.87 p < 0.001). The higher LFP values were correlated with the duration of immunosuppressive treatment, total duration of topical corticosteroid use and the risk for development of ocular complications at all follow-ups (all p < 0.001). No significant correlation was found between the AC cell grades and the duration of immunosuppressive treatment, topical corticosteroid use and the prevalence of complications. Conclusion LFP measurements have a predictive value of monitoring the course of uveitis and the occurrence of ocular complications, and it should be considered as a primary modality to monitor intraocular inflammation in children with chronic anterior uveitis.
Muscle responses during radial nerve-biased upper limb neurodynamic test in asymptomatic individuals: a cross-sectional study

ABSTRACT This laboratory cross-sectional study aimed at explore the muscle response (MR) of the upper trapezius, infraspinatus, biceps brachii and extensor carpi radialis brevis (ECRB) during the radial nerve-biased upper limb neurodynamic test (RN-ULNT) in healthy participants. Myoelectric activity was stage-by-stage recorded during two sequencing variants of the RN-ULNT: S1, in which elbow extension was the last movement; and S2, in which wrist flexion was the last movement. Final elbow and wrist joint angle and sensory response (SR) in five zones (Z1-Z5) were also registered. MR was qualitatively categorized as ‘absent’ (No-MR), ‘true’ (TMR) or ‘uneven’ (UMR). In both sequences, significant increases in muscle activity occurred mostly during shoulder abduction and elbow extension (p ≤ 0.009). Also, elbow extension but not wrist flexion increased the activity of the ECRB muscle (p ≤ 0.009). S2 showed significantly higher upper trapezius (p = 0.04) and biceps brachii (p = 0.036) muscle activity during wrist flexion, and higher report of SR in Z1 and Z4 (p < 0.001) compared to S1. Only the ECRB muscle showed significant differences in the MR type between S1 and S2 (TMR, p = 0.016; UMR, = 0,012). Our results may be useful in the assessment of upper limb musculoskeletal disorders.
TN-ZSTAD: Transferable Network for Zero-Shot Temporal Activity Detection

An integral part of video analysis and surveillance is temporal activity detection, which means to simultaneously recognize and localize activities in long untrimmed videos. Currently, the most effective methods of temporal activity detection are based on deep learning, and they typically perform very well with large scale annotated videos for training. However, these methods are limited in real applications due to the unavailable videos about certain activity classes and the time-consuming data annotation. To solve this challenging problem, we propose a novel task setting called zero-shot temporal activity detection (ZSTAD), where activities that have never been seen in training still need to be detected. We design an end-to-end deep transferable network TN-ZSTAD as the architecture for this solution. On the one hand, this network utilizes an activity graph transformer to predict a set of activity instances that appear in the video, rather than produces many activity proposals in advance. On the other hand, this network captures the common semantics of seen and unseen activities from their corresponding label embeddings, and it is optimized with an innovative loss function that considers the classification property on seen activities and the transfer property on unseen activities together. Experiments on the THUMOS’14, Charades, and ActivityNet datasets show promising performance in terms of detecting unseen activities.
Novel genes and sex differences in COVID-19 severity

Abstract Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.