Miracle-dz/UniFAR-FTUs huggingface dataset:
Roxadustat (FG-4592) Facilitates Recovery From Renal Damage by Ameliorating Mitochondrial Dysfunction Induced by Folic Acid

Incomplete recovery from acute kidney injury induced by folic acid is a major risk factor for progression to chronic kidney disease. Mitochondrial dysfunction has been considered a crucial contributor to maladaptive repair in acute kidney injury. Treatment with FG-4592, an inhibitor of hypoxia inducible factor prolyl-hydroxylase, is emerging as a new approach to attenuate renal damage; however, the underlying mechanism has not been fully elucidated. The current research demonstrated the protective effect of FG-4592 against renal dysfunction and histopathological damage on the 7th day after FA administration. FG-4592 accelerated tubular repair by promoting tubular cell regeneration, as indicated by increased proliferation of cell nuclear antigen-positive tubular cells, and facilitated structural integrity, as reflected by up-regulation of the epithelial inter-cellular tight junction molecule occludin-1 and the adherens junction molecule E-cadherin. Furthermore, FG-4592 ameliorated tubular functional recovery by restoring the function-related proteins aquaporin1, aquaporin2, and sodium chloride cotransporter. Specifically, FG-4592 pretreatment inhibited hypoxia inducible factor-1α activation on the 7th day after folic acid injection, which ameliorated ultrastructural abnormalities, promoted ATP production, and attenuated excessive reactive oxygen species production both in renal tissue and mitochondria. This was mainly mediated by balancing of mitochondrial dynamics, as indicated by down-regulation of mitochondrial fission 1 and dynamin-related protein 1 as well as up-regulation of mitofusin 1 and optic atrophy 1. Moreover, FG-4592 pretreatment attenuated renal tubular epithelial cell death, kidney inflammation, and subsequent interstitial fibrosis. In vitro, TNF-α-induced HK-2 cells injury could be ameliorated by FG-4592 pretreatment. In summary, our findings support the protective effect of FG-4592 against folic acid-induced mitochondrial dysfunction; therefore, FG-4592 treatment can be used as a useful strategy to facilitate tubular repair and mitigate acute kidney injury progression.
Motivation and Technology Acceptance in a Neuroscience Student Lab—An Empirical Comparison Between Virtual Experiments With and Without Hands-on Elements

Out-of-school laboratories, also called student labs, are an advantageous opportunity to teach biological subjects. Particularly in the case of complex fields such as neurobiology, student labs offer the opportunity to learn about difficult topics in a practical way. Due to numerous advantages, digital student labs are becoming increasingly popular nowadays. In this study, we investigated the effect of an electrophysiological setup for a virtual experiment with and without hands-on elements on participant motivation and technology acceptance. For this purpose, 235 students were questioned during a student laboratory day. The surveyed students showed high motivation and technology acceptance for the virtual experiment. In the comparison, the electrophysiological setup with hands-on elements performs better in the intrinsic components than the setup without hands-on elements: Thus, the hands-on approach is rated as more interesting and the perceived enjoyment scores higher. Nevertheless, both experimental groups show high values, so that the results of the study support the positive influence of digital laboratory as well as a positive influence of hands-on elements.
Coated Zinc Oxide Improves Growth Performance of Weaned Piglets via Gut Microbiota

Weaned piglets stayed in transitional stages of internal organ development and external environment change. The dual stresses commonly caused intestinal disorders followed by damaged growth performance and severe diarrhea. High dose of zinc oxide could improve production efficiency and alleviate disease status whereas caused serious environmental pollution. This research investigated if coated ZnO (C_ZnO) in low dose could replace the traditional dose of ZnO to improve the growth performance, intestinal function, and gut microbiota structures in the weaned piglets. A total of 126 cross-bred piglets (7.0 ± 0.5 kg body weight) were randomly allocated into three groups and fed a basal diet or a basal diet supplemented with ZnO (2,000 mg Zn/kg) or C_ZnO (500 mg Zn/kg), respectively. The test lasted for 6 weeks. C_ZnO improved average daily gain (ADG) and feed efficiency, alleviated diarrhea, decreased the lactulose/mannitol ratio (L/M) in the urine, increased the ileal villus height, and upregulated the expression of Occludin in the ileal tissue and the effect was even better than a high concentration of ZnO. Importantly, C_ZnO also regulated the intestinal flora, enriching Streptococcus and Lactobacillus and removing Bacillus and intestinal disease-associated pathogens, including Clostridium_sensu_stricto_1 and Cronobacter in the ileal lumen. Although, colonic microbiota remained relatively stable, the marked rise of Blautia, a potential probiotic related to body health, could still be found. In addition, C_ZnO also led to a significant increase of acetate and propionate in both foregut and hindgut. Collectively, a low concentration of C_ZnO could effectively promote growth performance and reduce diarrhea through improving small intestinal morphology and permeability, enhancing the barrier function, adjusting the structure of gut microbiota, and raising the concentration of short-chain fatty acids (SCFAs) in the weaned piglets.
Monthly Variation in Flux of Inorganic Nutrients From Submarine Groundwater Discharge in a Volcanic Island: Significant Nitrogen Contamination in Groundwater

To determine nutrient fluxes derived from submarine groundwater discharge (SGD), we conducted monthly hydrological surveys on the coast of Jeju, a volcanic island located in the southern sea of Korea. The concentrations of dissolved inorganic nitrogen (DIN), dissolved inorganic phosphorus (DIP), and dissolved silicon (DSi) were significantly correlated with salinity, indicating that fresh SGD (FSGD) is a major nutrient source in Jeju Island where no other coastal freshwater origins exist. Based on a DSi-mass balance model, seepage rate of FSGD was found to depend on 5-day precipitation before sampling campaigns, which immediately permeated via porous aquifers. Thus, the FSGD-driven nutrient fluxes were generally higher in rainy season (July–August) and September 2019 when typhoons occurred. However, high DIN and DIP fluxes were found during spring (March–May), even at low seepage rate, perhaps by a fertilizer input from agriculture activity. This study highlights that large variation of the SGD-driven nutrient fluxes was caused by environmental and anthropogenic factors and emphasizes on the importance of long-term investigation.
Curcumin-Loaded mPEG-PLGA Nanoparticles Attenuates the Apoptosis and Corticosteroid Resistance Induced by Cigarette Smoke Extract

The present study was aim to prepare curcumin-loaded methoxypolyethylene-glycols-poly (lactic-co-glycolic acid) nanoparticles (Cur-mPEG-PLGA-NPs) and investigate curcumin’s effect on reversing corticosteroid resistance induced by cigarette smoke extract (CSE) in rat tracheal epithelial (RTE) cells. The Cur-mPEG-PLGA-NPs were spherical, regular in shape with smooth surfaces, and well distributed and Cur-mPEG-PLGA-NP suspensions had good water solubility and presented prolonged release. Furthermore, we found that Cur-mPEG-PLGA-NPs were internalized more than curcumin into the cells and significantly alleviated apoptosis in RTE cells. In addition, 10% CSE reduced the maximal inhibition percentage and increased the half-inhibitory concentration of budesonide (BUD) on IL-8 secretion, and curcumin restored the efficacy of BUD inhibition. BUD in combination with Cur-mPEG-PLGA-NPs showed higher inhibitory rates for LPS- and CSE-induced IL-8 secretion than that in combination with curcumin. Moverover, the relative expression levels of HDAC2 was reduced after CSE exposure and curcumin could improve HDAC2 expression and reverse CSE-induced corticosteroid resistance. Curcumin in high concentration and Cur-mPEG-PLGA-NPs restored HDAC2 levels in RTE cells and thus Cur-mPEG-PCL-NPs have higher biological activity than curcumin.
Non-Invasive Monitoring for Rejection in Kidney Transplant Recipients After SARS-CoV-2 mRNA Vaccination

Introduction Studies have shown reduced antiviral responses in kidney transplant recipients (KTRs) following SARS-CoV-2 mRNA vaccination, but data on post-vaccination alloimmune responses and antiviral responses against the Delta (B.1.617.2) variant are limited. Materials and methods To address this issue, we conducted a prospective, multi-center study of 58 adult KTRs receiving mRNA-BNT162b2 or mRNA-1273 vaccines. We used multiple complementary non-invasive biomarkers for rejection monitoring including serum creatinine, proteinuria, donor-derived cell-free DNA, peripheral blood gene expression profile (PBGEP), urinary CXCL9 mRNA and de novo donor-specific antibodies (DSA). Secondary outcomes included development of anti-viral immune responses against the wild-type and Delta variant of SARS-CoV-2. Results At a median of 85 days, no KTRs developed de novo DSAs and only one patient developed acute rejection following recent conversion to belatacept, which was associated with increased creatinine and urinary CXCL9 levels. During follow-up, there were no significant changes in proteinuria, donor-derived cell-free DNA levels or PBGEP. 36% of KTRs in our cohort developed anti-wild-type spike antibodies, 75% and 55% of whom had neutralizing responses against wild-type and Delta variants respectively. A cellular response against wild-type S1, measured by interferon-γ-ELISpot assay, developed in 38% of KTRs. Cellular responses did not differ in KTRs with or without antibody responses. Conclusions SARS-CoV-2 mRNA vaccination in KTRs did not elicit a significant alloimmune response. About half of KTRs who develop anti-wild-type spike antibodies after two mRNA vaccine doses have neutralizing responses against the Delta variant. There was no association between anti-viral humoral and cellular responses.
26 June 2006

Despite the increasing attention towards customer experience, empirical research to explain this notion and its consequences is still limited. Hence, this study aims to examine the effect of customer’s experience with four dimensions on their emotions and satisfaction. A convenience sampling technique was used to select a sample of 600 at two tourist spots of Malaysia i.e., Langkawi and Penang. 450 questionnaires were returned back and the data was analysed using partial least square based structural equation modelling. Findings reveal that all the four dimensions of customer experience influence customer emotions which develop customer satisfaction. Resort hotels are least focused facet of tourism industry; therefore, this study validates the customer experience scale in the context of resort hotels and enhances the theoretical progress on the experience concept in relation with customer emotions and satisfaction and offer important implications for resort hotel marketers. © 2016 Varna University of Management. All rights reserved
What If Unmotivated Is More Dangerous? The Motivation-Contingent Effectiveness of Misinformation Correction on Social Media

This study examines the effect of misinformation correction on social media, contingent on the motivational factors heightened by social media when users are strongly opinionated. A 2 (uncertainty: low vs. high) × 2 (risk: low vs. high) × 2 (personal relevance: low vs. high) × 2 (attitudinal congruence with correction: incongruent vs. congruent) pretest and posttest factorial online experiment of 973 U.S. participants was conducted to examine the effectiveness of correction while controlling for misinformation source credibility. Findings suggest that correction is effective in decreasing social media users’ perceived credibility and sharing intention toward misinformation even when they are polarized on the issue of the misinformation. Interestingly, while this study confirms previous literature that users are biased toward proattitudinal correction sources than counterattitudinal ones, misinformation correction is also significantly more effective in decreasing perceived credibility and sharing intention when users are motivated by the personal relevance, uncertainty, and risks associated with the misinformation.
The Development of Virtual Laboratory-based STEM Approach Equipped Feedback to Improve Critical Thinking Skills on Acid-Base Concept

The purpose of this research is to produce development products of virtual laboratory media with a STEM approach and equipped with appropriate feedback to be applied in learning and the opportunity to improve critical thinking skills on acid-base concepts. This research consisted of (1) analysis (needs analysis and front-end analysis), (2) design, and (3) development. The research instrument used consisted of interview questionnaires, media feasibility validation sheets, material feasibility, concept validity, and readability test questionnaires. Media and subject matter experts who are involved are a teacher, a lecturer, and 33 students as respondents to test readability. While The results showed that the product virtual labs application, user guide, and a feedback book has a percentage of 89 % for feasibility media, 85% for the feasibility of the material, and 100% for the truth of a concept that can be in the category is very feasible. The media readability test by students obtained a percentage result of 81 % with a very good category. Therefore, this virtual laboratory is very feasible to be applied in learning activities and has the opportunity to improve students’ critical thinking skills on the acid-base concept. Recommended future research can apply this product in classroom learning.
EXAMINING THE VISIBILITY OF SOCIAL RESPONSIBILITY ON THE WEBSITES OF HUNGARIAN STATE UNIVERSITIES

The paper investigates university social responsibility at Hungarian universities by examining their websites. Although the concept of university social responsibility has existed for nearly 20 years, the scope of its research and theoretical literature still falls far short of that of corporate social responsibility. There is extant literature on the topic including case studies from around the world showing the importance of university social responsibility. Nevertheless, the scope of thematic analysis of the topic is very narrow with only a few pieces of comprehensive systematic research published so far, and the theoretical literature only highlights the work of some major researchers. Due to the complexity of the topic, the amount of previous literature attempting to explore the effects of university social responsibility is also limited. The aim of this paper is to investigate how terms relating to social responsibility appear on the websites of Hungarian universities. In autumn 2019 research was carried out involving twenty-one universities. The paper analyses how social responsibility is visible on university websites based on given keywords. The research employed quantitative content analysis. The hypothesis was that based on visibility the same university categories can be formed according to the size and profile of the institutions. According to the authors’ present knowledge no such research has been carried out in Hungary so far. There are some university website researches in different countries but with different purposes with the special focus on sustainability. So the method of the present research is an attempt to find out how to measure the social responsibility visibility of universities and how to make categorizations based on the analyses. The limitation of the research is, among others, that universities have different search engines on their websites, which can lead to the misinterpretation of results. The main findings are that the visibility of social responsibility based on website analyses depends not only on the size and profile of the institutions; therefore, the investigation of visibility can contribute to the creation of new categories proving that social responsibility is far beyond the size or profile of the universities. The findings can help institutions develop the conscious communication of their social responsibility activity, and provide assistance to the research community.
Budi Prasetyo Widyobroto et al. The Effects of Cassava Pomace and Protected Soybean Meal on Dairy Milk

The objective of the study was to determine the effect of cassava pomace and protected soybean meal on dairy milk production and quality of mid lactating dairy cows. This research was conducted at Turen, Malang from January to April 2020. Twelve lactating Friesian Holstein dairy cows were divided into 2 groups so that each group consisted of 6, namely the control and treatment groups. The feed were a combination of forage and concentrate with a ratio of 35:65 in dry matter (DM). The control group received wet concentrate with DM content of 30.58%, 14.87% CP, and 75.06% TDN, while the treatment groups received concentrate with supplementation of cassava pomace 15% of DM ratio and protected soybean meal 45 g/l milk production. The variables observed were nutrient consumption, milk production and quality. Data between the two groups were analyzed using the Independent Sample T-test. The results showed that the addition of waste cassava and protected soybean meal increased (P<0.05) nutrient consumption (DM, OM, CP, CF, EE, and TDN). Milk production in the treatment group was higher (P<0.05) than control group (9.46 vs. 6.07 Ls/head/day). Milk protein production in the treatment group was higher (P<0.05) than control group (0.37 vs. 0.21 L/head/day). The content of milk protein and milk fat between the control and treatment groups was not significantly different (respectively 3.19 Vs 3.28; 4.46 vs 4.42 %). Milk protein and fat production in the treatment group was higher (P<0.05) than control group (0.21 vs 0.37; and 0.50 vs. 0.30 L/head/day respectively). The composition of glucose and blood urea in control and treatment dairy cows were not significantly different. In conclusion, giving cassava pomace and protected soybean meal to dairy cows during mid lactation increased nutrient consumption, milk production, milk protein production, and milk fat production but did not increase percentage of milk protein and fat. The treatment also did not affect blood glucose and nitrogen urea contents.
Determinants of Local Government Accountability: Evidence from Central Java Province, Indonesia

This research aims to examine the factors that determine local government accountability as a dependent variable measured by the audit opinion of the financial statements. Specifically, the focus of this research was based on a local government located in Central Java, Indonesia, where the determinants include several variables, such as management control systems, economic growth, local government size, complexity, fiscal decentralization, human development index, and the population. Meanwhile, 138 financial statements were used in this research, which were provided by the local governments in Central Java province during the 2015-2018 observation. Regression is used to test the effect of determinant variables on local government accountability and the result of the statistical test shows that local government size, economic growth, and fiscal decentralization have a significant effect on local government accountability. While the total assets and economic growth have a positive effect on accountability, fiscal decentralization has a negative effect. Management control systems, human development index, and complexity, on the other hand, have no significant effect on accountability. Therefore, this research concludes that it is important to consider these determinant variables for local government accountability.
Prevalence of Orthorexia Nervosa Tendency in Non-obese Population : A Cross-sectional Study

©Copyright 2021 by Anatolian Journal of Family Medicine Available online at www.anatoljfm. org INTRODUCTION Eating disorders are serious health concerns that result from early-onset low self-esteem and negative thoughts about food, body weight, and physical appearance. [1] Orthorexia nervosa (ON) is not currently recognized as a psychiatric disorder in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) and the International Classification of Diseases (ICD-10). [2,3] The term of ON was first used in 1997 by Bratman to describe an obsession for healthy nutrition. [4] ON is described as having an obsession with the quality of nutrition, eating healthy/pure foods rather than the amount of food consumed, and their fit appearance. In time, it may result in an eating disorder as the diet becomes more compulsive in contemporary society. [5,6] The interest in the body and the will to keep it healthy have become “obsessive” and sometimes leads to eating behaviors based on the compulsive search for natural and “pure” foods. [7] A growing number of PubMed articles refer to orthorexia as a keyword with a tendency to increase in publications. [8] Objectives: The prevalence of eating disorders has increased in the modern population. This study aimed to describe the presence of orthorexia nervosa (ON) tendency in non-obese population.
Tracking Changes in the Area, Thickness, and Volume of the Thwaites ‘B30’ Tabular Iceberg ‘B30’ Observed using by Satellite Altimetry and Imagery

Icebergs account for half of all ice loss from Antarctica and, once released, present a hazard to maritime operations. Their melting leads to a redistribution of cold fresh water around the Southern Ocean which, in turn, influences water circulation, promotes sea ice formation, and fosters primary production. In this study, we combine CryoSat-2 satellite 10 altimetry with MODIS and Sentinel-1 satellite imagery and meteorological data to track changes in the area, freeboard, thickness, and volume of the B30 tabular iceberg between 2012 and 2018. We track the iceberg elevation when it was attached to Thwaites Glacier and on a further 106 occasions after it calved using Level 1b CryoSat data, which ensures that measurements recorded in different acquisition modes and within different geographical zones are consistently processed. From these data, we mapped the iceberg’s freeboard and estimated its thickness taking snowfall and changes in snow and 15 ice density into account. We compute changes in freeboard and thickness relative to the initial average for each overpass and compare theseis time series to estimates from precisely located tracks using the satellite imagery. This comparison shows that our time series of iceberg freeboard change is in good agreement with the geolocated overpasses (correlation coefficient 0.87), and suggests that geolocation colocation reduces the freeboard uncertainty by 1.6 m. We also demonstrate that the snow layer has a significant impact on iceberg thickness change. Changes in the iceberg area are measured by 20 tracing its perimeter and we show that alternative estimates based on arc lengths recorded in satellite altimetry profiles and on measurements of the semi-major and semi-minor axes also capture the trend, though with a 48 % overestimate and a 15 % underestimate, respectively. Since it calved, the area of B30 has decreased from 1500 ± 60 to 426 ± 27 km, its mean freeboard has fallen from 49.0 ± 4.6 to 38.8 ± 2.2 m, and its mean thickness has reduced from 315 ± 36 to 198 ± 14 m. The combined loss amounts to an 80 ± 16 % reduction in volume, two thirds (69 ± 14 %) of which is due to fragmentation and 25 the remainder (31 ± 11 %) is due to basal melting.