Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Drinking Water Quality and Bacterial Antibiotic Sensitivity in Wells and Standpipes at Household Water Points in Freetown, Sierra Leone

Water quality surveillance can help to reduce waterborne diseases. Despite better access to safe drinking water in Sierra Leone, about a third of the population (3 million people) drink water from unimproved sources. In this cross-sectional study, we collected water samples from 15 standpipes and 5 wells and measured the physicochemical and bacteriological water quality, and the antimicrobial sensitivity of Escherichia coli (E. coli) in two communities in Freetown, Sierra Leone in the dry and wet seasons in 2021. All water sources were contaminated with E. coli, and all five wells and 25% of standpipes had at least an intermediate risk level of E. coli. There was no antimicrobial resistance detected in the E. coli tested. The nitrate level exceeded the WHO’s recommended standard (>10 parts per million) in 60% of the wells and in less than 20% of the standpipes. The proportion of samples from standpipes with high levels of total dissolved solids (>10 Nephelometric Turbidity Units) was much higher in the rainy season (73% vs. 7%). The level of water contamination is concerning. We suggest options to reduce E. coli contamination. Further research is required to identify where contamination of the water in standpipes is occurring.
Evaluating the analgesic and sedative effects of intravenous ketamine versus morphine administration on relieving long/short bone-fracture pain in the upper/ lower limbs; a phase II clinical trial

Introduction: The importance of pain control in patients with limb trauma admitted to emergency departments as well as its complications is among the main concerns in post-emergency care, which contributes to the accelerated improvement of patients’ conditions in a significant manner. Objectives: The present study was to evaluate the analgesic and sedative effects of intravenous (IV) ketamine versus morphine administration on relieving long/short bone-fracture pain in the upper/lower limbs. Patients and Methods: The present study is as a double-blind randomized clinical trial. For this purpose, the effect of ketamine and morphine were initially examined using IV ketamine and morphine administration, respectively, at the doses of 0.4 and 0.1 mg/kg/IV/10 min in patients, aged 18-65 years with limb trauma, and admitted to hospital emergency departments. Afterward, the duration of the analgesic effect, the amount of pain relief, according to the visual analog scale (VAS) outcomes, and the complications for each drug, including apnea, bradycardia, tachycardia, altered level of consciousness, nausea, vomiting, hypertension/hypotension, seizures and disturbed sleep were compared, and then the preferred method was introduced. Results: In this study, 120 patients in total, including 60 cases receiving ketamine and 60 individuals receiving morphine, were recruited. The participants’ age range was between 19 -70 years. The patients’ mean age was 47.04±12.57 years of whom 89 patients (74.2%) were male. The study results indicated that the potency of the low-dose ketamine infusion in relieving pain in patients was comparable to that of morphine. Conclusion: It was concluded that ketamine could be administered as an alternative to IV morphine to reduce long/short bone-fracture pain in the upper/lower limbs. Trial Registration: The trial protocol was authorized by the Iranian Registry of Clinical Trials, (identifier: IRCT20170716035105N3; https://en.irct.ir/trial/26628, ethical code: IR.AJUMS.REC.1396.248).
Stability and Anti-Aging of Encapsulated Ferulic Acid in Phosphorylated Rice Starch

Ferulic acid (FA) provides broad biological functions that have been used in cosmetics formulation as a photoprotection, anti-aging, and brightening agent. However, its application is limited by its tendency to deteriorate by exposure to heat, humidity, and light. This study aimed to enhance the stability of FA by encapsulation in phosphorylated rice starch (PRS) and evaluate its effect on improving human skin. First, FA was encapsulated in PRS and characterized by FTIR, SEM, XRD, and DSC. Then, its stability when exposed to a temperature of 45 °C and light and its anti-aging effect on 16 volunteers were investigated. The results indicated that FA was successfully encapsulated in PRS with an encapsulation yield of 77%, EE (73%) and LE (65%). After 1 month at the high temperature/80%RH, the encapsulated FA retained its quantity (70%), whereas free FA was retained at only 50%. Under light exposure conditions, the encapsulated FA was retained at 65%, which was higher than FA (35%). Franz diffusion cell was used and demonstrated that PRS provided the controlled release of FA. Application of encapsulated FA and FA creams showed an absence of skin irritation in all volunteers. After 1 month, the encapsulated FA cream was found to be better than the FA cream on skin lightening, elasticity, smoothness, roughness, scaliness, and wrinkle. The results indicated that PRS is a potential wall material for enhancing the stability of FA, resulting in more efficacious skin lightening and anti-aging properties.
Age of Acquisition of Personality Terms: Implications for Personality Theory

Analysis of the age of acquisition (AoA) of personality terms represents a genetic method for the study of the individual personality lexicon and offers a potential alternative to correlational analysis for identifying the fundamental personality descriptors among the thousands of terms that appear in language. In the present study, the relationship between AoA, word frequency, word desirability, and factor loading in the Big Five and Hexaco models of 274 and 408 personality adjectives was analyzed. It was found that young children (2nd graders or younger) acquire personality terms that represent traits at the core of the broad personality factors in the Big Five and Hexaco models slightly earlier than words that represent more peripheral traits. In older children beyond second grade, the correlation between factor loading and AoA is weak. Words that describe the broad openness and stability/emotionality aspects of personality are learned later than words for the other broad factors. Word frequency (in book texts) and desirability have a weak negative correlation with AoA. It is hypothesized that the AoA of a personality term reflects the importance of the corresponding trait for children and may be used as one criterion for ranking facet level traits independent of the broad factors.
Allelopathic Effect of Lantana (Lantana camara) and Siam Weed (Chromolaena odorata) on Selected Crops

Laboratory, greenhouse, and field studies were conducted to determine the allelopathic potential of lantana and Siam weed on the germination and growth of five crops. Emergence and dry weight of bioassay species were affected when lantana or Siam weed debris was present on the soil surface or incorporated into the soil. However, presence of Siam weed on the soil surface did not affect dry weight of rape. Emergence and dry weight of crops (except emergence of spinach) were not affected when crops were grown in soil samples collected from beneath field-grown lantana. Dry weight of Chinese cabbage and chilli was reduced when these crops were grown in Siam weed-contaminated soil. Germination of Chinese cabbage, chilli, and rape decreased progressively when exposed to increasing concentrations of aqueous lantana extract. However, the lantana extract at full strength (66.7 g L−1) did not reduce germination of spinach and cucumber seed. Siam weed extract, when applied at full strength to seed of spinach, Chinese cabbage, rape, and chilli, reduced germination by 10, 12, 21, and 19% of control, respectively. Full-strength extract of lantana and Siam weed decreased seedling length and fresh weight of all crops.
Expression of TRP Channels in Colonic Mucosa of IBS-D Patients and Its Correlation with the Severity of the Disease

Aim Lots of researches have endeavored to elucidate the pathogenetic mechanism of visceral hypersensitivity in order to guide the therapy of diarrhea predominant-irritable bowel syndrome (IBS-D). Transient receptor potential (TRP) channels and their role in visceral nociception have been vastly investigated. We investigated the expression of TRP channels in IBS-D colonic biopsies and its correlation with the severity of the disease. Methods Sigmoid biopsies were obtained from 34 IBS-D patients and 28 healthy controls (HCs). IBS-D was diagnosed according to Rome IV criteria. Their clinical parameters were assessed through questionnaires. Expression of TRPV1, TRPV4, TRPA1, TRPM2, and TRPM8 was evaluated with immunohistology staining. Results Expression levels of TRPV1, TRPV4, and TRPA1 in the colonic mucosa of IBS-D patients were significantly higher than those in HCs (p < 0.05), while there was no obvious difference of TRPM2 and TRPM8 expression between IBS-D patients and HCs. In addition, the expression levels of TRPV1 and TRPA1, but TRPV4, in the colonic mucosa correlated positively with the severity of diseases (r = 0.6303 and 0.4506, respectively, p < 0.05). Conclusions Expression of TRPV1, TRPA1, and TRPV4 in the colonic mucosa was enhanced in IBS-D patients compared with HCs with the former two correlated with the severity of the disease. TRP channels might be promising biomarkers in the diagnosis and estimate of the severity in IBS-D.
The Mediation Role of Customer Satisfaction and Trust in The Effect of Online Shopping Experience on Repurchasing Intention

The purpose of this study is to examine and explain the effect of the online shopping experience on customers' repurchase intentions mediated by customer satisfaction and trust of Traveloka users. This research is included in quantitative research in associative form. This research was conducted in Denpasar City with a total sample of 112 respondents. The results of respondents' answers were collected through questionnaires with validity and reliability tests. The analysis technique in this study uses the Structural Equation Model (SEM) and SmartPLS 3.2. 9 software. The results show that the online shopping experience has a positive and significant effect on repurchase intentions, satisfaction, and customer trust. Customer satisfaction and trust have a positive and significant effect on customers' repurchase intentions and can partially mediate the influence of online shopping experience variables on customers' repurchase intentions.
Comparison of Online Accessibility Evaluation Tools: An Analysis of Tool Effectiveness

The use of online tools is a common practice for evaluating the accessibility of a website, identifying problems, and providing useful feedback on how to fix detected issues. For ease of accessibility validation, many tools have been developed and implemented successfully over the years. Yet, the results of these tools show differences in terms of coverage, correctness, and reporting-related issues. In this study, we compared online accessibility evaluation tools to understand to what extent they differ in detecting accessibility problems in websites. A total of 41 government websites of different countries were tested for violations of accessibility guidelines using six evaluation tools. We observed that each tool generated different evaluation data for the same websites. As some of the tools are complementary to each other, meaning the highest coverage and completeness can be possible with the right combination of evaluation tools. Therefore, we suggest different tools should be utilized to provide consistency and obtain reliable data from online evaluation tools, thereby improving tool effectiveness.
Vitamin Supplementation Protects against Nanomaterial-Induced Oxidative Stress and Inflammation Damages: A Meta-Analysis of In Vitro and In Vivo Studies

The extensive applications of nanomaterials have increased their toxicities to human health. As a commonly recommended health care product, vitamins have been reported to exert protective roles against nanomaterial-induced oxidative stress and inflammatory responses. However, there have been some controversial conclusions in regards to this field of research. This meta-analysis aimed to comprehensively evaluate the roles and mechanisms of vitamins for cells and animals exposed to nanomaterials. Nineteen studies (seven in vitro, eleven in vivo and one in both) were enrolled by searching PubMed, EMBASE, and Cochrane Library databases. STATA 15.0 software analysis showed vitamin E treatment could significantly decrease the levels of oxidants [reactive oxygen species (ROS), total oxidant status (TOS), malondialdehyde (MDA)], increase anti-oxidant glutathione peroxidase (GPx), suppress inflammatory mediators (tumor necrosis factor-α, interleukin-6, C-reactive protein, IgE), improve cytotoxicity (manifested by an increase in cell viability and a decrease in pro-apoptotic caspase-3 activity), and genotoxicity (represented by a reduction in the tail length). These results were less changed after subgroup analyses. Pooled analysis of in vitro studies indicated vitamin C increased cell viability and decreased ROS levels, but its anti-oxidant potential was not observed in the meta-analysis of in vivo studies. Vitamin A could decrease MDA, TOS and increase GPx, but its effects on these indicators were weaker than vitamin E. Also, the combination of vitamin A with vitamin E did not provide greater anti-oxidant effects than vitamin E alone. In summary, we suggest vitamin E alone supplementation may be a cost-effective option to prevent nanomaterial-induced injuries.
Incidence, Clinicomicrobiological Characteristics, Risk Factors, and Treatment ‎Outcomes of Bacterial Infections Following Liver Transplantation in Pediatrics: A ‎Retrospective Cohort Study

Background: Liver transplantation (LT) is the definitive treatment for patients with advanced liver failure. Bacterial infections are common consequences of organ transplantation resulting from immune suppression and prolonged hospitalization. Methods: This retrospective cohort study examined the records of all liver transplant pediatrics under 18 years of age in Abu-Ali Sina hospital, Shiraz, Fars province, Iran, from April 2019 to February 2020. Demographic, laboratory, and clinical data were extracted along with the administered therapeutic approach for the patient. Results: Of 80 enrolled patients, 52 were male, and 28 were female, with a median age of 60 months. An incidence of 67.9% of bacterial infections was recorded. Gram-negative and Gram-positive pathogens accounted for 64.06% and 35.93% of infections, respectively. Surgical site infections were the most common ones. The length of ICU stay, hospitalization, mechanical ventilation duration, and re-hospitalization were significantly higher in the infected group than in non-infected pediatrics (P-value < 0.05). Multivariate regression analysis showed that the only risk factor for bacterial infections after LT was the length of ICU stay. The mortality rate was 22%, which was significantly higher among the infection group (P = 0.008). Conclusions: A high rate of bacterial infections and an increasing prevalence of nosocomial and antibiotic-resistant pathogens were detected in the early period after LT.
Effect of Using Partial Continuounity by External Post-Tension on The Simple Composite Beams as a Strengthening Technique

Composite steel-concrete beams are used widely in bridge and building construction as the main structural elements in flexure. These structures have a design life and this may be reduced if loads are increased or environmental degradation occurs. Strength of such structure members and thus replacement or retrofitting may need to be considered. One method of retrofitting (stiffening and strengthening) a composite steel-concrete beam is to externally post-tension the beam. The present study focuses on evaluating the effect of adding the external post-tension as a strengthening technique on the simple composite beams. The study was conducted using the finite element program "ANSYS". Nonlinear material models for the components of the composite beam were used in the finite element model. The outcomes got from finite element analysis were confirmed against available experimental results. A broad parametric study was conducted to explore the effect of tendons profiles on flexural behaviour. This covers: load deflection behaviour, converting the simple beam into partially continuous beam, verifying an external post-tensioned simple beam.
Instructional Boundary Management during COVID-19

Instructional Boundary Management is an area of school leadership comprising activities that simultaneously involve instructional leadership and boundary management. This study explores principals’ Instructional Boundary Management during COVID-19. Data collection consisted of semi-structured interviews with a diverse sample of 33 Israeli elementary school principals. Data analysis indicated that principals felt an increasing need to carry out most Instructional Boundary Management activities during COVID-19. The findings suggest that COVID-19 influenced principals’ needs through the following three factors: the challenges that COVID-19 posed to teachers, the challenges that COVID-19 posed to students and parents, and the transition from face-to-face instruction to distance learning. These findings reveal the mechanisms through which COVID-19 affected Instructional Boundary Management activities, explaining how and why COVID-19 has led to a greater need for principals’ Instructional Boundary Management.
Vortex generator installation studies on steady state and dynamic inlet distortion

The theoretical and experimental work carried out under the NASA/MOD Joint Aeronautical Program has shown that CFD vortex generator installations designs successfully managed inlet duct flow distortion and that significant benefits in flow unsteadiness at the engine face were also present. The main conclusions to date from the collaborative effort between NASA/Lewis and DRA/Bedford are as follows: (1) vortex generator installations can be designed to be effective over a wide range of inlet operating conditions using Computational Fluid Dynamics and formal optimization procedures, (2) reductions in steady state engine face distortion of up to 80% have been measured in the M2129 inlet S-duct using CFD designed vortex generator installations, (3) reductions in flow unsteadiness of up to 80% have been measured in the M2129 inlet S-duct using CFD designed vortex generator installations, and (4) the Reduced Navier-Stokes code RNS3D is a useful tool to design vortex generator installations to manage engine face distortions over a wide range of inlet operating conditions.
Properties and Microstructure of High Strength Concrete Incorporating Different Supplementary Cementitious Materials

The construction industry has recently focused on the use of sustainable and innovative building materials, which called for the production of many supplementary cementitious materials with concrete to make the concrete produced durable and sustainable. Since high-strength concrete has many advantages other than its high strength, it has recently been used in non-traditional applications after for a long time confined to well-known traditional applications. This study presents the effect of micro Ferrosilicon (FS) and mineral materials on high-strength concrete properties, where silica fume (SF), FS, and metakaolin (Mk) were used as additives to cement.Besides the consistency test, all-ages compressive strength, splitting tensile strength, modulus of elasticity strengthand water permeability were investigated on the produced HSC.Microstructure analyses are carried out by SEM and EDX tests. The results showed a continuous decrease in a slump with the increase in mineral material, however, 15% FS and 15% MK were determined as the optimum percentage of the desired mechanical property. HSC performs up to 88 MPa compressive strength, 7.49 MPa tensile strength, and 39.89 GPa modulus of elasticity, as well as good durability properties. Finally, the high-strength concrete under consideration is suitable for use in both conventional and non-conventional applications and supports sustainable development and infrastructure development.
Targeting Akt/NF-κB/p53 Pathway and Apoptosis Inducing Potential of 1,2-Benzenedicarboxylic Acid, Bis (2-Methyl Propyl) Ester Isolated from Onosma bracteata Wall. against Human Osteosarcoma (MG-63) Cells

Onosma bracteata Wall. is an important medicinal and immunity-enhancing herbs. This plant is commonly used in the preparation of traditional Ayurvedic drugs to treat numerous diseases. Inspired by the medicinal properties of this plant, the present study aimed to investigate the antiproliferative potential and the primary molecular mechanisms of the apoptotic induction against human osteosarcoma (MG-63) cells. Among all the fractions isolated from O. bracteata, ethyl acetate fraction (Obea) showed good antioxidant activity in superoxide radical scavenging assay and lipid peroxidation assay with an EC50 value of 95.12 and 80.67 µg/mL, respectively. Silica gel column chromatography of ethyl acetate (Obea) fraction of O. bracteata yielded a pure compound, which was characterized by NMR, FTIR, and HR-MS analysis and was identified as 1,2-benzene dicarboxylic acid, bis (2-methyl propyl) ester (BDCe fraction). BDCe fraction was evaluated for the antiproliferative potential against human osteosarcoma MG-63, human neuroblastoma IMR-32, and human lung carcinoma A549 cell lines by MTT assay and exhibited GI50 values of 37.53 μM, 56.05 μM, and 47.12 μM, respectively. In MG-63 cells, the BDCe fraction increased the level of ROS and simultaneously decreased the mitochondria membrane potential (MMP) potential by arresting cells at the G0/G1 phase, suggesting the initiation of apoptosis. Western blotting analysis revealed the upregulation of p53, caspase3, and caspase9 while the expressions of p-NF-κB, p-Akt and Bcl-xl were decreased. RT-qPCR studies also showed upregulation in the expression of p53 and caspase3 and downregulation in the expression of CDK2, Bcl-2 and Cyclin E genes. Molecular docking analysis displayed the interaction between BDCe fraction with p53 (−151.13 kcal/mol) and CDK1 (−133.96 kcal/mol). The results of the present work suggest that the BDCe fraction has chemopreventive properties against osteosarcoma (MG-63) cells through the induction of cell cycle arrest and apoptosis via Akt/NF-κB/p53 pathways. This study contributes to the understanding of the utilization of BDCe fraction in osteosarcoma treatment.