Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple HPV infection as possible marker of neoplastic progression

Background : Some studies in the literature suggest a possible role of multiple HPV infections as a prognostic factor in the development and progression of cervical neoplasia. we studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion Methods: 921 women with clinical HPV manifestations were enrolled. Inclusion criteria were: positive at the cytology for HPV lesions, presence of preneoplastic and neoplastic lesions of the uterine cervix diagnosed by the histology examination All the patients underwent colposcopy and cervical biopsy with viral genotyping. The search for viral DNA was carried out using polymerase chain reaction. Genotype 16 is correlated with the majority of CIN2+; we divided the multiple HPV16 infections into “infections with 16 as the first genotype” (16mHPV) (e.g. HPV 16 , 31, 52) and into “ infections containing 16” (m16HPV) (e.g. HPV 31, 16 , 52), we then divided them based on the number of genotypes present: infections with 2 strains, 3 strains, 4 strains, and > 4 strains. Results: We analyzed the differences between single and multiple infections with HPV16, the patients with single infections had a higher incidence of CIN2+ (83.3%) with respect to those with multiple infections (71.4%). The 16mHPV infection was significative for CIN2/CIN3. When the prevalence of the combinations between the genotypes was studied, we found that in 16mHPV infection HPV16, 18 and HPV 16, 31 were the most common combinations of mHPV infection (50%) and the most frequent in CIN2/CIN3 The 16mHPV infection with 2 genotypes, with respect to the infections with 3 or more genotypes, was significative with an OR= 7.94 (IC% 2.55-24.73). Conclusions: Our results suggest that single HPV infections give a higher risk of SCC development with respect to multiple HPV infections. Among multiple infections, only 16mHPV infection with 2 genotypes is associated with CIN2/CIN3 in a significative way and it presents an 8 times greater risk of developing a high grade lesion.
Analisis Pengaruh Karakteristik Perusahaan dan Tata Kelola Perusahaan terhadap Pengungkapan Sustainability Report

The objective of this study is to examine and analyze the correlation of company characteristics and corporate governance towards sustainability report disclosure. The company characteristics mentioned before consist of company size, leverage level, profitability level, and liquidity level, while the corporate governance consist of the board of directors’s meeting frequency and audit committee’s meeting frequency. Companies listed in the Indonesia Stock Exchange from 2014 to 2018 are the objects of this research. Data that needs to be collected are financial reports, annual reports, and sustainability reports if available. Purposive sample is the sampling technique used in this study by establishing certain characteristics that are in line with the objectives of the study. There are 301 companies used as samples. The data that has been collected will then be processed with a software called SPSS Version 22 which is analyzed with the logistic regression model. The test results in this study explain that company size, profitability, and the board of directors have a positive effect on sustainability report disclosure, while leverage and the audit committee don’t have any significant effects on the sustainability report disclosure. In addition, there are also significant negative results indicated by the liquidity variable on the sustainability report disclosure. This is triggered by the company's poor financial condition, so companies with low liquidity tend to disclose more additional information such as sustainability reports so that investors will continue to invest in the company.
Primary prevention of coronary artery disease based on genetic prediction

Prevention of coronary artery disease (CAD) following a cardiac event has been successful by modifying known conventional risk factors, such as cholesterol. These risk factors are age-dependent and less effective for primary prevention. To halt the pandemic spread of CAD, the number one killer in the world requires primary prevention of cardiac events. 50 percent of all Americans will experience a cardiac event; the challenge is identifying those asymptomatic individuals at risk. Genetics account for 40-60 percent of predisposition for CAD. Since the discovery of the first genetic risk variant, 9p21, in 2007, hundreds of genetic risk variants had been discovered. The genetic burden for CAD can be expressed in a single number, referred to as the Genetic Risk Score (GRS). Retrospective genotyping of clinical trials performed to assess the effect of statin therapy confirmed that GRS improves risk stratification of CAD and detects those benefitting most from statin therapy. In a prospective study of 55,685 individuals, the group with the high GRS had a 91 percent higher risk for cardiac events. Individuals with a healthy lifestyle, and a high GRS, had a 46 percent lower risk for cardiac events in comparison to those with an unfavorable lifestyle. In another trial, risk stratification by GRS showed those at highest genetic risk and performed the most physical activity, had a 50 percent reduction in cardiac events. Genetic risk stratification for CAD has been shown to be superior to conventional risk factors, and the risk is markedly attenuated by lifestyle changes and drug therapy. Genetic risk for CAD can be determined at any time; from birth on since one’s DNA does not change in one’s lifetime. Utilizing the GRS to risk stratify young, asymptomatic individuals could provide a paradigm shift in the primary prevention of CAD and significantly halt its pandemic spread. *Correspondence to: Robert Roberts, MD, University of Arizona College of Medicine, Professor, Dignity Health, Director of Cardiovascular Genomics & Genetics, 500 W. Thomas Road, Suite 900B, Phoenix, AZ 85013, Tel: 602-5409878; E-mail: Robert.Roberts@dignityhealth.org
PRODUÇÃO DE MUDAS DE ESSÊNCIAS FLOREST AIS EM DIFERENTES SUBSTRATOS E ACOMPANHAMENTO DO DESENV OLVIMENTO EM CAMPO Yield of seedling species forestry of four using different substrates and development in field

3. Os substratos no viveiro foram constituidos de diversas combinacoes dos seguintes materiais: humus de minhoca, esterco bovino curtido, esterco de galinha, turfa, casca de amendoim processada, casca de arroz carbonizada e palha de cafe. Na primeira etapa foi utilizado o delineamento inteiramente casualizado (DIC). Foram avaliadas as variaveis morfologicas das mudas e suas relacoes. O delineamento estatistico no campo foi em blocos, em parcelas subdivididas e as covas foram preenchidas com dois diferentes tipos de adubacoes - esterco bovino e esterco bovino + condicionador de solo. Nessa etapa, foram avaliadas as variaveis altura e diâmetro das plantas. Os dados foram submetidos a analise de variância e ao teste de media (Newman-Keuls 5%). Conforme os resultados obtidos na etapa de viveiro, os substratos que podem ser recomendados para producao de mudas das especies estudadas foram os a base de Humus de minhoca, casca de amendoim processada e turfa. Na etapa de campo, a adubacao com esterco bovino + condicionador de solo proporcionou maiores valores das variaveis em todas as especies, com excecao da altura das plantas para a acacia.
Diagnostic value of the hamstring to quadriceps ratio in monitoring of the effectiveness of supervised 6-month physiotherapy in males after Anterior Cruciate Ligament Reconstruction (ACLR).

PURPOSE The aim of the study was to assess the usefulness of isometric torque (IT) and peak torque (PT) of the hamstring to quadriceps muscles ratio (H/Q ratio) in monitoring the effectiveness of physiotherapy (PH) in males after ACLR. HYPOTHESIS The H/Q ratio is a diagnostic tool for monitoring of the effectiveness of the 6- month PH after ACLR. METHODS Twenty males 6 months after ACLR (ACLR group) and 20 male controls underwent IT and PT (60°/s and 180°/s) bilateral measurements of H and Q muscles. The IT and PT were normalized to body mass, and expressed as relative IT (RIT) and relative PT (RPT). The RIT and RPT H/Q ratios, and Limb Symmetry Index (LSI) were calculated. RESULTS In the ACLR group, the RIT for the H and Q, the RIT for the H/Q ratio and most of the RPT, as well as the H/Q ratio, ROM and LSI values of the operated knee, were not significantly different (NSD) than those of the non-operated side (NOS) or the control group. The between-group comparison of the H/Q ratio for RIT and RPT weren't NSD. The isokinetic test at 180 °/s showed lower RPT, H/Q ratio and LSI values for the Q muscle than those of the NOS (p = 0.042, p = 0.001). CONCLUSIONS The H/Q ratio, in combination with the RIT, RPT and LSI, is a useful diagnostic tool for monitoring the effectiveness of 6-month PH after ACLR. Restoring the correct H/Q ratio can reduce the risk factor for ACL graft rupture.
Energy-efficient computation offloading and resource allocation in SWIPT-based MEC Networks

Recent years, 5G networks have become an important role in accelerating the development of social intelligence. But it also increases energy consumption and data ﬂow. In order to guarantee the experience of network users, an adaptive SWIPT-based MEC network is proposed. The network consists of multiple user equipment (UE) and multiple mobile edge computing (MEC) servers. The MEC server can make up for the shortcomings of the UE’s insufﬁcient computing capability, and Simultaneous Wireless Information and Power Transfer (SWIPT) can send energy to the UE without pollution to make up for the shortcomings of limited battery energy. Added, we increase the utilization of sub-channels, improve the adaptability of the SWIPT-based MEC network to the environment, lengthen the battery life, and optimize the UE’s energy efﬁciency of the network. We also propose a three-part alternative optimization algorithm framework based on the categories of optimization variables. The ﬁrst part combines the Alternating Direction Multiplier Method (ADMM) and Dinkelbach’s algorithm to optimize continuous variables. And for directly optimize the integer variables of the other two parts, without converting them to continuous variables. The second part adjusts the ofﬂoading decision by comparing the energy consumption of the two computation modes, and the third part proposes the integer Bat algorithm to assign sub-channel. The simulation results show that the energy efﬁciency of the binary ofﬂoading algorithm proposed in this paper is 11% higher than the approximate algorithm based on the binary ofﬂoading KKT algorithm, and the relationship between various preset parameters and energy efﬁciency in the network is discussed.
Evaluation of Elemental Distributions in Wild-Caught and Farmed Pangasius sp. Using Pattern Recognition Techniques

The concentrations of Na, Mg, K, Ca, Cr, Fe, Ni, Cu, Zn, As, Se, and Pb in various tissues of Pangasius sp. were determined using microwave-assisted digestion/inductively coupled plasma–mass spectrometry. The clustering tendency related to elemental patterns associated with tissue variants and fish habitats were explored using hierarchical cluster analysis and principal component analysis. The results revealed that the general elemental accumulation pattern was strongly dependent on the type of tissue, whereas latent deviations within particular tissue samples can be linked to the natural variability between wild-caught and farmed fish. The inherent elemental patterns allowed us to differentiate between those wild-caught and farmed fish through linear discrimination analysis with 100% precision. In terms of food safety, the elemental concentrations in edible muscle were found to be far below the legal limits, as the associated health risks at the 90th percentile were well within tolerable regions, although wild-caught fish were found to pose a higher risk.
Effects of EDTA on adsorption of Cd(II) and Pb(II) by low-permeability soil minerals and on their microscopic characteristics

Background Ethylenediaminetetraacetic acid (EDTA) can serve as a washing agent in the remediation of low-permeability layers contaminated by heavy metals (HMs). Therefore, batch adsorption experiments, where quartz sands (SM1) and mineral mixtures (SM2) were used as low-permeability soil minerals (SMs), were implemented to explore the effects of different EDTA concentrations, pH and exogenous chemicals on the HM-SM-EDTA adsorption system. Changes in microscopic characterizes of SMs were determined by instrument analysis to investigate the mechanisms.Results As the EDTA concentration increased gradually, it gradually cut down the maximum Cd adsorption capacities of SM1 and SM2 from approximately 135 to 55 mg/kg and 2,660 to 1,453 mg/kg; and the maximum Pb adsorption capacities of SM1 and SM2 were reduced from 660 to 306 mg/kg and 19,677 to 19,262 mg/kg, respectively. When the mole ratio (MR = moles of HM ions / sum of moles of HM ions and EDTA) was closer to 0.5, the effect of EDTA was more effective; and Freundlich isotherm model fitted better to the data. It took 5 to 10 min for EDTA to begin taking its effect. EDTA worked well at pH below 7.0 and 4.0 for Cd and Pb, respectively. Low-molecular-weight organic acids (LMWOAs) affected the system mainly by bridging, complexation, adsorption site competition and reductive dissolution. Cu 2+ , Fe 2+ ions could greatly increase the Cd and Pb adsorption on SM2. There were feature changes in mineral particles including attachment of EDTA and microparticles, agglomeration, connection and smoother surfaces, making the specific surface area decrease from 16.73 to 12.59 m 2 /g.Conclusion All findings indicated that EDTA could effectively and economically reduce the HM adsorption capacity of SMs at the reasonable MR value, contact time and pH. The extent of the effects of LMWOAs and exogenous metal ions on the HM-SM-EDTA system depended on the synthesis of diverse effects and the selectivity of EDTA, respectively. EDTA reduced the HM adsorption capacity of SMs not only by complexation with HM ions, but also decreasing SSA and blocking active sites. Hence, the acquired insight from the presented study can help to promote the remediation of contaminated soil and groundwater.
Standardization of recipe and juice extraction method for preparation of ready-to-serve beverage from custard apple (Annona squamosa L.).

Custard apple (Annona squamosa L.) known as sitaphal is delicious and nutritionally valuable fruit grown at higher elevations (2000 MSL) in tropic. It is highly perishable in nature and available for short period from 1 week of October to third week of November. Being perishable with poor self life it needs quick disposal. Further, short duration of its availability as well as a good harvest during peak season creates a glut in the market. Consequently the growers are compelled to self their produce at low price, which causes economic losses to them. Considering the various point an experiment was conducted for value addition with custard apple fruit in different combinations and was observed that hot method + 15% blended juice of custard apple and lime (3:2) + 15% TSS + 0.2% acidity was found best with respect to colour (off white), taste, over-all acceptance and ascorbic acid.
Efficacy and safety of artesunate-amodiaquine and artemether-lumefantrine and prevalence of molecular markers associated with resistance, Guinea, 2016

Background: Antimalarial resistance is a threat to recent gains in malaria control. This study aimed to assess the efficacy and safety of artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) in the management of uncomplicated malaria and to measure the prevalence of molecular markers of resistance of Plasmodium falciparum in sentinel sites in Maferinyah and Labé Health Districts in Guinea in 2016.Methods: This was a two-arm randomized controlled trial of the efficacy of AL and ASAQ in children aged 6-59 months with P. falciparum monoinfection in two sites. Children were followed for 28 days to assess clinical and parasitological response. The primary outcome was the Kaplan-Meier estimate of Day 28 (D28) efficacy after correction by microsatellite-genotyping. Pre-treatment (D0) and day of failure samples were assayed for molecular markers of resistance in the pfk13 and pfmdr1 genes.Results: A total of 421 participants were included with 211 participants in the Maferinyah site and 210 in Labé. No early treatment failure was observed in any study arms. However, 22 (5.3%) participants developed a late treatment failure, which were further classified as 2 recrudescences and 20 reinfections. The Kaplan-Meier estimate of the corrected efficacy at D28 was 100% for both AL and ASAQ in Maferinyah site and 99% (95% Confidence Interval: 97.2-100%) for ASAQ and 99% (97.1-100%) for AL in Labé. The majority of successfully analyzed D0 (98%, 380/389) and all day of failure (100%, 22/22) samples were wild type for pfk13. All 9 observed pfk13 mutations were polymorphisms not associated with artemisinin resistance. The NFD haplotype was the predominant haplotype in both D0 (197/362, 54%) and day of failure samples (11/18, 61%) successfully analyzed for pfmdr1.Conclusions: This study observed high efficacy and safety of both ASAQ and AL in Guinea, providing evidence for their continued use to treat uncomplicated malaria. Continued monitoring of ACT efficacy and safety and molecular makers of resistance in Guinea is important to detect emergence of parasite resistance and to inform evidence-based malaria treatment policies.
POTENSI LACTOBACILLUS YANG DIISOLASI DARI AIR SUSU IBU UNTUK MENCEGAH DIARE [Potential of Lactobacillus Isolated from Breast Milk to Prevent Diarrheae]

Some of Lactobacillus species isolated from breast milk are known to have antimicrobial activities, including against Escherichia coli. The aims of this study were to evaluate the antimicrobial activity of Lactobacillus species isolated from breast milk against enteropathogenic Escherichia coli strain K1.1 and the effectiveness of the Lactobacillus isolates to prevent diarrhea on rats (Sprague Dawley). The infective dose of E. coli K1.1 to induce diarrhea without causing death were also determined. Based on the antimicrobial activity there were three isolates of Lactobacillus that exhibited good inhibition againts E. coli K1.1, i.e. Lactobacillus rhamnosus R14, L. rhamnosus R23, and L. rhamnosus B16. Determination of E. coli infective dose showed that 10 8 CFU of E. coli K1.1 was sufficient to induce diarrhea on rat without causing death. The number of diarrhea rats and severity level in group treated with L. rhamnosus were lower than groups untreated with the Lactobacilli. This study showed that the three L. rhamnosus isolated from breast milk were able to prevent diarrhea due to infection of E. coli K1.1 when the Lactobacillus was regularly introduced prior to infection. L. rhamnosus R23 showed the best capabilities of preventing diarrhea in rats as compared to two other isolates of Lactobacillus. The incidence of diarrhea correlated with the number of lactobacilli in the feces. However when the period of diarrhea ceased, there were no difference in total lactobacilli and E. coli in the caecum, colon and feces between rats treated with L. rhamnosus and the control. This finding revealed the L. rhamnosus isolated from breast milk were potential for prevention of diarrhea when consumed regularly.
Bregman subgradient extragradient method with monotone self-adjustment stepsize for solving pseudo-monotone variational inequalities and fixed point problems

Using the concept of Bregman divergence, we propose a new subgradient extragradient method for approximating a common solution of pseudo-monotone and Lipschitz continuous variational inequalities and fixed point problem in real Hilbert spaces. The algorithm uses a new self-adjustment rule for selecting the stepsize in each iteration and also, we prove a strong convergence result for the sequence generated by the algorithm without prior knowledge of the Lipschitz constant. Finally, we provide some numerical examples to illustrate the performance and accuracy of our algorithm in finite and infinite dimensional spaces.
High-throughput profiling of diapause regulated genes from Trichogramma dendrolimi, an important egg parasitoid

Background: The parasitoid wasp Trichogramma dendrolimi can successfully enter diapause at the prepupal stage. Thus, diapause is an efficient preservation method during the mass production of T. dendrolimi . Previous studies on diapause have focused largely on ecological characteristics, so the molecular mechanism of diapause in T. dendrolimi is mostly unknown. In this study, we compared transcriptomes of diapause and non-diapause T. dendrolimi to identify key genes and pathways involved in the development of diapause. Results: Transcriptome sequencing was performed using different samples, including diapause prepupae, pupae after diapause, normal prepupae, and pupae. Initially, it yielded a total of 87,022 unigenes with an average length of 1,604 bp. By removing redundant sequences and those without significant BLAST hits, a non-redundant dataset was generated, containing 7,593 sequences with an average length of 3,351 bp. Among them, 5,702 genes were differentially expressed. The result of Gene Ontology (GO) enrichment analysis revealed that regulation of transcription, DNA-templated, oxidation-reduction process, and signal transduction were significantly affected. Ten genes were selected for validation using a quantitative real-time PCR (qPCR). The changes showed the same trend between the qPCR and RNA-Seq results. Based on our data, several genes were identified to be involved in diapause, including ribosomal proteins, zinc finger proteins, homeobox proteins, forkhead box proteins, UDP-glucuronosyltransferase , Glutathione-S-transferase , p53 , DNA damage-regulated gene 1 ( pdrg1 ), and genes related to lipid metabolism were also included. Conclusions: In this study, we generated a great amount of transcriptome data from T. dendrolimi , providing a resource for gene function research. The diapause-related genes that we identified establish a valuable basis for future studies on the molecular mechanisms of diapause, not only for T. dendrolimi , but for other species as well.
Molecular mobility in crystallising aromatic thermoplastic polyimide R-BAPS

The molecular mobility of the thermoplastic aromatic R-BAPS polyimide films based on 1,3-bis (3,3’-4,4’-dicarboxyphenoxy) benzene (dianhydride) and 4,4’-bis (4-aminophenoxy) biphenyl was studied using the dielectric method. Two relaxation regions of dipole polarisation caused by local mobility of phenylene groups in the diamine (γ process) and in the diamine and dianhydride macromolecule parts (β process) were identified in the glassy state, In the high-elastic state, two relaxation processes, α and αMWS, were also observed. The α process is due to the large-scale segmental mobility of macromolecules. The αMWS process is caused by the relaxation at the boundary between amorphous and crystalline regions, i.e., the Maxwell-Wagner-Sillars relaxation. Moreover, a structural transition due to melting was observed in the initial samples.