Miracle-dz/UniFAR-FTUs huggingface dataset:
Auroral, Ionospheric and Ground Magnetic Signatures of Magnetopause Surface Modes

Surface waves on Earth's magnetopause have a controlling effect upon global magnetospheric dynamics. Since spacecraft provide sparse in situ observation points, remote sensing these modes using ground‐based instruments in the polar regions is desirable. However, many open conceptual questions on the expected signatures remain. Therefore, we provide predictions of key qualitative features expected in auroral, ionospheric, and ground magnetic observations through both magnetohydrodynamic theory and a global coupled magnetosphere‐ionosphere simulation of a magnetopause surface eigenmode. These show monochromatic oscillatory field‐aligned currents (FACs), due to both the surface mode and its non‐resonant Alfvén coupling, are present throughout the magnetosphere. The currents peak in amplitude at the equatorward edge of the magnetopause boundary layer, not the open‐closed boundary as previously thought. They also exhibit slow poleward phase motion rather than being purely evanescent. We suggest the upward FAC perturbations may result in periodic auroral brightenings. In the ionosphere, convection vortices circulate the poleward moving FAC structures. Finally, surface mode signals are predicted in the ground magnetic field, with ionospheric Hall currents rotating perturbations by approximately (but not exactly) 90° compared to the magnetosphere. Thus typical dayside magnetopause surface modes should be strongest in the East‐West ground magnetic field component. Overall, all ground‐based signatures of the magnetopause surface mode are predicted to have the same frequency across L‐shells, amplitudes that maximize near the magnetopause's equatorward edge, and larger latitudinal scales than for field line resonance. Implications in terms of ionospheric Joule heating and geomagnetically induced currents are discussed.
Homogeneity of turbulence generated by static-grid structures

Homogeneity of turbulence generated by static grids is investigated with the help of hot-wire measurements in a wind-tunnel and direct numerical simulations based on the Lattice Bolztmann method. It is shown experimentally that Reynolds stresses and their anisotropy do not become homogeneous downstream of the grid, independent of the mesh Reynolds number for a grid porosity of 64%, which is higher than the lowest porosities suggested in the literature to realize homogeneous turbulence downstream of the grid. In order to validate the experimental observations and elucidate possible reasons for the inhomogeneity, direct numerical simulations have been performed over a wide range of grid porosity at a constant mesh Reynolds number. It is found from the simulations that the turbulence wake behind the symmetric grids is only homogeneous in its mean velocity but is inhomogeneous when turbulence quantities are considered, whereas the mean velocity field becomes inhomogeneous in the wake of a slightly non-uniform grid. The simulations are further analysed by evaluating the terms in the transport equation of the kinetic energy of turbulence to provide an explanation for the persistence of the inhomogeneity of Reynolds stresses far downstream of the grid. It is shown that the early homogenization of the mean velocity field hinders the homogenization of the turbulence field.
X-ray generation in an ion channel

X-ray generation by relativistic electrons in an ion channel is studied. The emission process is analyzed in the regime of high harmonic generation when the plasma wiggler strength is large. Like for the conventional free electron laser, the synchrotron-like broadband spectrum is generated in this regime. An asymptotic expression for the radiation spectrum of the spontaneous emission is derived. The radiation spectrum emitted from an axisymmetric monoenergetic electron beam is analyzed. The stimulated emission in the ion channel is studied and the gain of the ion-channel synchrotron-radiation laser is calculated. It is shown that the use of laser-produced ion channels leads to a much higher power of x-ray radiation than the one in a self-generated channel. In addition, the mean photon energy, the number of emitted photons and the brilliance of the photon beam increase dramatically. Three-dimensional particle-in-cell simulations of a 25-GeV electron bunch propagating in a laser-produced ion channel are mad.
Salinity and Mulching Effects on Nutrition and Production of Grafted Sour Passion Fruit

The Brazilian semiarid region stands out in terms of sour passion fruit production. Local climatic conditions (high air temperature and low rainfall), combined with its soil properties (rich in soluble salts), increase salinity effects on plants. This study was carried out in the experimental area “Macaquinhos” in Remígio-Paraíba (Brazil). The aim of this research was to evaluate the effect of mulching on grafted sour passion fruit under irrigation with moderately saline water. The experiment was conducted in split-plots in a 2 × (2 × 2) factorial scheme to evaluate the effects of the combination of irrigation water salinity of 0.5 dS m−1 (control) and 4.5 dS m−1 (main plot), passion fruit propagated by seed and grafted onto Passiflora cincinnata, with and without mulching (subplots), with four replicates and three plants per plot. The foliar Na concentration in grafted plants was 90.9% less than that of plants propagated via seeds; however, it did not affect fruit production. Plastic mulching, by reducing the absorption of toxic salts and promoting greater absorption of nutrients, contributed to greater production of sour passion fruit. Under irrigation with moderately saline water, the plastic film in the soil and seed propagation promote higher production of sour passion fruit.
Tidal perturbations of linear, isentropic oscillations in components of circular-orbit close binaries - II. Validity of the perturbation method applied to equilibrium tides

The paper is devoted to a verification of the validity of a first-order perturbation method that was developed in an earlier paper and allows one to determine the effects of an equilibrium tide on linear, isentropic oscillations of a component in a close binary. The verification is done by a comparison between results obtained by the perturbation method and results obtained in other ways, in the cases of two simple models: the compressible equilibrium sphere with uniform mass density and the polytropic model with index n = 3. In the first case, a comparison is made with second-harmonic oscillations in compressible Jeans spheroids with a small eccentricity, and in the second case, with results determined by Saio (1981) for a rotationally and tidally distorted polytrope. For the comparison, the second-harmonic oscillations of the incompressible and the compressible Jeans spheroids are redetermined by means of a method of direct integration of the governing equations which has the advantage of yielding exact analytical solutions of the eigenfrequency equations.
Risk factors for ICU mortality in patients with hematological malignancies: a single-center, retrospective cohort study from Turkey

Background/aim Patients with hematological malignancies (HM) often require admission to the intensive care unit (ICU) due to organ failure, disease progression or treatment-related complications, and they generally have a poor prognosis. Therefore, understanding the factors affecting ICU mortality in HM patients is important. In this study, we aimed to identify the risk factors for ICU mortality in our critically ill HM patients. Materials and methods We retrospectively reviewed the medical records of HM patients who were hospitalized in our medical ICU between January 1, 2010 and December 31, 2018. We recorded some parameters of these patients and compared these parameters by statistically between survivors and nonsurvivors to determine the risk factors for ICU mortality. Results The study included 368 critically ill HM patients who were admitted to our medical ICU during a 9-year period. The median age was 58 (49–67) years and 63.3% of the patients were male. Most of the patients (43.2%) had acute leukemia. Hematopoietic stem cell transplantation (HSCT) was performed in 153 (41.6%) patients. The ICU mortality rate was 51.4%. According to univariable analyses, a lot of parameters (e.g., admission APACHE II and SOFA scores, length of ICU stay, some laboratory parameters at the ICU admission, the reason for ICU admission, comorbidities, type of HM, type of HSCT, infections on ICU admission and during ICU stay, etc.) were significantly different between survivors and nonsurvivors. However, only high SOFA scores at ICU admission (OR:1.281, p = 0.004), presence of septic shock (OR:17.123, p = 0.0001), acute kidney injury (OR:48.284, p = 0.0001), and requirement of invasive mechanical ventilation support during ICU stay (OR:23.118, p = 0.0001) were independent risk factors for ICU mortality. Conclusion In our cohort, critically ill HM patients had high ICU mortality. We found four independent predictors for ICU mortality. Yet, there is still a need for further research to better understand poor outcome predictors in critically ill HM patients.
Grothendieck groups for categories of complexes

The new intersection theorem states that, over a Noetherian local ring R , for any non-exact complex concentrated in degrees n ,…,0 in the category P(length) of bounded complexes of finitely generated projective modules with finite-length homology, we must have n ≥ d = dim R . One of the results in this paper is that the Grothendieck group of P(length) in fact is generated by complexes concentrated in the minimal number of degrees: if P d (length) denotes the full subcategory of P(length) consisting of complexes concentrated in degrees d ,…0, the inclusion P d (length) → P(length) induces an isomorphism of Grothendieck groups. When R is Cohen–Macaulay, the Grothendieck groups of P d (length) and P(length) are naturally isomorphic to the Grothendieck group of the category M(length) of finitely generated modules of finite length and finite projective dimension. This and a family of similar results are established in this paper.
Performance Improvement on Traditional Chinese Task-Oriented Dialogue Systems With Reinforcement Learning and Regularized Dropout Technique

The development of conversational voice assistant applications has been in full swing around the world. This paper aims to develop traditional Chinese multi-domain task-oriented dialogue (TOD) systems. It is typically implemented using pipeline approach, where submodules are optimized independently, resulting in inconsistencies with each other. Instead, this paper implements end-to-end multi-domain TOD models using pre-trained deep neural networks (DNNs). This allows us to integrate all the submodules into one single DNN model to solve the inconsistencies. Data shortages are common in conversational natural language processing (NLP) tasks using DNN models. In this regard, dropout regularization has been widely used to improve overfitting caused by insufficient training dataset. However, the randomness it introduces leads to non-negligible discrepancies between training and inference. On the other hand, pre-trained language models have successfully provided effective regularization for NLP tasks. An inherent disadvantage is that fine-tuning the pre-trained language model suffers from exposure bias and loss-evaluation mismatch. To this end, we propose a reinforcement learning (RL) approach to address both issues. Furthermore, we adopt a method called regularized dropout (R-Drop) to improve the inconsistency in dropout layers of DNNs. Experimental results show that both our proposed RL approach and the R-Drop technique can significantly improve the joint target accuracy (JGA) score and combined score of traditional Chinese TOD system in tasks of dialogue state tracking (DST) and end-to-end sentence prediction, respectively.
New-age vaccine adjuvants, their development, and future perspective

In the present scenario, immunization is of utmost importance as it keeps us safe and protects us from infectious agents. Despite the great success in the field of vaccinology, there is a need to not only develop safe and ideal vaccines to fight deadly infections but also improve the quality of existing vaccines in terms of partial or inconsistent protection. Generally, subunit vaccines are known to be safe in nature, but they are mostly found to be incapable of generating the optimum immune response. Hence, there is a great possibility of improving the potential of a vaccine in formulation with novel adjuvants, which can effectively impart superior immunity. The vaccine(s) in formulation with novel adjuvants may also be helpful in fighting pathogens of high antigenic diversity. However, due to the limitations of safety and toxicity, very few human-compatible adjuvants have been approved. In this review, we mainly focus on the need for new and improved vaccines; the definition of and the need for adjuvants; the characteristics and mechanisms of human-compatible adjuvants; the current status of vaccine adjuvants, mucosal vaccine adjuvants, and adjuvants in clinical development; and future directions.
Validation of the Polish Problematic Tinder Use Scale and Its Relationship with Safe Sex Behaviors

Introduction: Online dating is a common phenomenon. The manageability and access of the application allows people to quickly reach many potential partners, which can increase risky sexual behaviors. The Problematic Tinder Use Scale (PTUS) was developed and validated in a Polish population by analyzing the reliability, validity, and factor structure of the responses given by Polish-speaking participants. Methods: Two samples of adult Tinder users were recruited online. The first study aimed to perform the reliability coefficient Cronbach’s, interrater analysis, exploratory, and confirmatory factor analysis. The second sample was recruited to investigate the factor structure by combining it with the Safe Sex Behavior Questionnaire (SSBQ). The sociodemographic data, such as hours of use and number of dates, were also investigated. Results: The Polish participants’ responses to the PTUS (sample 1: N = 271, sample 2: N = 162) revealed the one-factor structure of the tool. The reliability of the measurement was α = 0.80. The construct validity was confirmed. The results showed a significant, negative, and weak correlation between the PTUS and SSBQ scores and their subscales: risky sexual behaviors (r = −0.18), condom use (r = −0.22), and avoidance of body fluids (r = −0.17). Moreover, the number of partners met in the real world had a statistically significant, moderate relationship with the PTUS scores. Conclusions: The PTUS measurement is valid and reliable for the Polish population. The findings highlight the need for harm prevention strategies related to potentially addictive Tinder use, as well as the possible risky sexual behaviors associated with dating app use.
Three-Dimensional Flow in a Driven Cavity Subjected to an External Magnetic Field

In this paper, we study the three-dimensional (3D) flow of an electrically conducting fluid in a cubic cavity with the top wall moving and subjected to an external magnetic field. The governing flow and electromagnetic field equations are integrated by a second-order space and time accurate numerical scheme, implemented on a graphics processing unit (GPU) with high parallel efficiency. Solutions for several Reynolds and Stuart numbers have been obtained on sufficiently fine grids to achieve grid independent solutions. As expected, the magnetic field significantly influences the circulation in the cavity and modifies the shape and locations of the primary and secondary eddies. The observed flow patterns are illustrated graphically as well as through selected line plots and tabulated data. With increasing magnetic field strength, the center of the primary eddy is seen to shift to the top right corner. Further, situations where the flow is unsteady in the absence of the magnetic field have become steady after a certain value of the magnetic interaction parameter. [DOI: 10.1115/1.4029731]
CO Depletion in the Starless Cloud Core L1544

We present evidence for CO depletion toward the starless cloud core L1544. A comparison between C17O and the 1.3 mm continuum dust emission shows that CO is depleted by a factor of ~10 at the dust peak. Our observations are consistent with a model in which CO is condensed out onto dust grains at densities above nd ~ 105 cm-3. The corresponding radius of the "depleted region" is rd ~ 6500 AU, and we find that this depletion causes 2.3 M☉ of gas to be lost to view in molecular line emission. Optically thin high-density tracers, such as HC18O+ and D13CO+, show double-peaked profiles which suggest that we are observing superposed emission from the foreground and background undepleted layers with density below nd. We conclude from our data that the core is probably young (~104 yr old) and collapsing. For the component at VLSR = 7.1 km s-1 in this line of sight, we estimate [DCO+]/[HCO+] = 0.12 ± 0.02, which is larger by a factor of order 2 than values derived in other dense cloud cores.
Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice

Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We determined the effects of hepatocyte-specific (N-acetylgalactosamine-conjugated) antisense oligonucleotides targeting AGT (GalNAc AGT ASO) on AngII-mediated blood pressure (BP) regulation and atherosclerosis and compared its effects with losartan, an AngII type 1 (AT1) receptor blocker, in hypercholesterolemic mice. Eight-week-old male low-density lipoprotein (LDL) receptor deficient mice were administered vehicle or GalNAc AGT ASO (1, 2.5, or 5 mg/kg) subcutaneously beginning 2 weeks before the initiation of Western diet feeding. All mice were fed Western diet for 12 weeks. Their systolic BP was monitored by the tail-cuff technique, and the atherosclerotic lesion area was measured by an en face method. Although the effects of all 3 doses of GalNAc AGT ASO on plasma AGT concentrations were similar, GalNAc AGT ASO reduced BP and atherosclerotic lesion size in a dose-dependent manner. Subsequently, we compared the effects of GalNAc AGT ASO (5 mg/kg) with losartan (15 mg/kg/day). Compared to losartan, GalNAc AGT ASO led to more profound increases in plasma renin and reduction in BP but had similar effects on atherosclerosis. Remarkably, GalNAc AGT ASO also reduced liver steatosis, which was not observed in losartan-treated mice. In conclusion, the BP increase and atherosclerosis development in hypercholesterolemic mice are dependent on AngII generated from hepatic AGT. Deleting hepatic AGT improves diet-induced liver steatosis, and this occurs in an AT1 receptor-independent manner.
Similarity scaling and vorticity structure in high-Reynolds-number stably stratified turbulent wakes

The mean velocity profile scaling and the vorticity structure of a stably stratified, initially turbulent wake of a towed sphere are studied numerically using a high-accuracy spectral multi-domain penalty method model. A detailed initialization procedure allows a smooth, minimum-transient transition into the non-equilibrium (NEQ) regime of wake evolution. A broad range of Reynolds numbers, Re = UD/ν ∈ [5 × 103, 105] and internal Froude numbers, Fr = 2U/(ND) ∈ [4, 64] (U, D are characteristic velocity and length scales, and N is the buoyancy frequency) is examined. The maximum value of Re and the range of Fr values considered allow extrapolation of the results to geophysical and naval applications. At higher Re, the NEQ regime, where three-dimensional turbulence adjusts towards a quasi-two-dimensional, buoyancy-dominated flow, lasts significantly longer than at lower Re. At Re = 5 × 103, vertical fluid motions are rapidly suppressed, but at Re = 105, secondary Kelvin–Helmholtz instabilities and ensuing turbulence are clearly observed up to Nt ≈ 100. The secondary motions intensify with increasing stratification strength and have significant vertical kinetic energy. These results agree with existing scaling of buoyancy-driven shear on Re/Fr2 and suggest that, in the field, the NEQ regime may last up to Nt ≈ 1000. At a given high Re value, during the NEQ regime, the scale separation between Ozmidov and Kolmogorov scale is independent of Fr. This first systematic numerical investigation of stratified turbulence (as defined by Lilly, J. Atmos. Sci. vol. 40, 1983, p. 749), in a controlled localized flow with turbulent initial conditions suggests that a reconsideration of the commonly perceived life cycle of a stratified turbulent event may be in order for the correct turbulence parametrizations of such flows in both geophysical and operational contexts.
Impact of SARS-CoV-2/COVID-19 on Provision of Medical Care to Patients With Systemic Autoimmune Rheumatic Disease and the Practice of Rheumatology

The SARS-CoV-2 pandemic has had a significant impact on the healthcare field that resulted in changes to the way safe and effective medical care is delivered. The effects range from service disruption including ambulatory clinic closure due to both patient and provider concerns, to lack of capacity in hospital services. In rheumatology, there were other effects including viral infection-related autoantibody production, concerns about the use of systemic immunosuppression in the presence of an infectious pandemic and even concerns for viral infection-induced flares of rheumatic disease. Coronavirus disease 2019 (COVID-19) led to the rapid adoption of innovative technologies that permitted the introduction and increased use of telemedicine via a number of platforms. Rapid discoveries and innovations led to the development of diagnostic and therapeutic agents in the management of COVID-19. Scientific advancement and discoveries around COVID-19 infection, symptoms, autoantibody production, chronic sequela and the repurposing of rheumatic immunosuppressive agents led to improved survival and an expanded role for the rheumatologist. Rheumatologists may sometimes be involved in the diagnosis and management of the hospitalized COVID-19 patient. In the ambulatory clinic, a rheumatologist also helps to differentiate between symptoms of long COVID and those of systemic autoimmune rheumatic disease (SARD). Rheumatologists must also grapple with the concerns related to immunosuppressive therapy and the risk of COVID-19 infections. In addition, there are concerns around vaccine effectiveness in people with SARD and those on immunosuppressive medications. Although the SARS-CoV-2 pandemic and the effects on healthcare resulted in difficulties, both patients and providers have risen to the challenge. The long-term outcome of COVID-19 for the medical system and rheumatologists in particular is not yet fully understood and will need further study. This review concentrates on the changing role of the rheumatologists, improved understanding of rheumatic disease and immunosuppressive therapies in the wake of the pandemic and how this has led to an improvement in the care of patients with COVID-19.