Miracle-dz/UniFAR-FTUs huggingface dataset:
Gut Bacteria Selectively Altered by Sennoside A Alleviate Type 2 Diabetes and Obesity Traits

Accumulating evidences implicate that gut microbiota play an important role in the onset and prolongation of fat inflammation and diabetes. Sennoside A, the main active ingredient of Rhizoma Rhei (rhubarb), is widely used for constipation as a kind of anthranoid laxative (e.g., senna). Here, we put forward the hypothesis that the structural alteration of gut microbiota in obesity mice may be involved in the pathogenesis of type 2 diabetes (T2D) which may be ameliorated by Sennoside A. We investigated the appearance of obesity, insulin resistance, host inflammation, and leaky gut phenotype with or without Sennoside A in db/db mice. Horizontal fecal microbiota transplantation (FMT) was used to confirm the critical roles of gut microbiota in the amelioration of the indices in T2D mice after Sennoside A treatment. As a result, we found that Sennoside A administration markedly improved the indices in T2D mice and obesity-related traits including blood glucose level, body weight, lipid metabolism disorder, and insulin resistance. The gut microbiota changed quickly during the onset of T2D in db/db mice, which confirmed the hypothesis that gut microbiota was involved in the pathogenesis of T2D. Sennoside A altered gut microbial composition which might mediate the antiobesogenic effects in T2D remission. Sennoside A also reduced inflammation and increased tight junction proteins in the ileum in gene-deficient mice via gut microbiota alteration. FMT lowered the blood glucose level and improved insulin resistance, corroborating that Sennoside A perhaps exerted its antiobesogenic effects through gut microbiota alteration. Chemical Compounds Studied in This Article. Compounds studied in this article include Sennoside A (PubChem CID: 73111) and metformin hydrochloride (PubChem CID: 14219).
InP-based multi-quantum-well mole fraction variation effects on a double wafer-fused GaAs/InP LW-VCSEL

We analyze the effects of the mole fraction variation of III-V heterostructures employed as the active region in an InP-based multi-quantum-well (MQW), long-wavelength vertical-cavity surface-emitting laser (LW-VCSEL). The VCSEL model which utilizes an air-post design for electrical current confinement is equipped with GaAs/AlGaAs and GaAs/AlAs top and bottom distributed Bragg reflectors(DBR) mirrors respectively. The changes in the quantum well band-gap energy is evaluated against the laser performance in terms of its threshold current, gain, lasing wavelength and emission power by means of an industrial-based numerical simulator. The simulated device achieved lasing powers up to 4.9 mW with modal gain of 25 cm -1 , lasing wavelength of 1.56 µm and threshold current <0.8 mA for In 1-xGa xAs yP1-y quantum well (QW) and quantum well barrier (QWB) mole fraction of x QW = 0.24, y QW = 0.82, x QWB = 0.52 and y QWB = 0.82. Results from this work is beneficial for optical design engineers to determine the appropriate material to be used in the active region of a LW-VCSEL.
Drp-1 as Potential Therapeutic Target for Lipopolysaccharide-Induced Vascular Hyperpermeability

Mitochondria-dependent apoptotic signaling has a critical role in the pathogenesis of vascular hyperpermeability (VH). Dynamin-related protein-1- (Drp-1-) mediated mitochondrial fission plays an important role in mitochondrial homeostasis. In the present study, we studied the involvement of Drp-1 in resistance to VH induced by lipopolysaccharide (LPS). To establish the model of LPS-induced VH, LPS at 15 mg/kg was injected into rats in vivo and rat pulmonary microvascular endothelial cells were exposed to 500 ng/ml LPS in vitro. We found that depletion of Drp-1 remarkedly exacerbated the mitochondria-dependent apoptosis induced by LPS, as evidenced by reduced apoptosis, mitochondrial membrane potential (MMP) depolarization, and activation of caspase-3 and caspase-9. Increased FITC-dextran flux indicated endothelial barrier disruption. In addition, overexpression of Drp-1 prevented LPS-induced endothelial hyperpermeability and upregulated mitophagy, as evidenced by the loss of mitochondrial mass and increased PINK1 expression and mitochondrial Parkin. However, the mitophagy inhibitor, 3-Methyladenine, blocked these protective effects of Drp-1. Furthermore, inhibition of Drp-1 using mitochondrial division inhibitor 1 markedly inhibited LPS-induced mitophagy and aggravated LPS-induced VH, as shown by increased FITC-dextran extravasation. These findings implied that Drp-1 strengthens resistance to mitochondria-dependent apoptosis by regulating mitophagy, suggesting Drp-1 as a possible therapeutic target in LPS-induced VH.
Body Mass Index (BMI) and Its Influence on the Cardiovascular and Operative Risk Profile in Coronary Artery Bypass Grafting Patients: Impact of Inflammation and Leptin

Background Obesity is related to coronary artery disease (CAD) and worse outcomes in coronary artery bypass graft (CABG) patients. Adipose tissue itself is an endocrine organ that secretes many humoral mediators, such as adipokines, which can induce or reduce inflammation and oxidative stress. Objectives We investigate the relationship between the body mass index (BMI), inflammation, and oxidative stress by measuring serum levels of leptin, interleukin-6, and 3-nitrotyrosine in CABG patients and correlate their levels to the cardiovascular and operative risk profiles. Methods and Results 45 men (<75 years) with a median BMI of 29 (21-51) kg/m2, who were diagnosed with CAD and scheduled for elective CABG, were included after applying the following exclusion criteria: prior myocardial infarction, reoperation, female gender, and smoking. Patients' blood samples were taken preoperatively. Several markers were measured. We found significant correlations between leptin and BMI (p < 0.0001) as well as between leptin and 3-nitrotyrosine (p = 0.006). Interleukin-6 was correlated with C-reactive protein (p < 0.0001) and with the incidence of insulin-dependent diabetes mellitus (p = 0.036), arterial hypertension (p = 0.044), reduced left ventricular function (p = 0.003), and severe coronary calcification (p = 0.015). It was also associated with significantly longer extracorporeal bypass time (p = 0.009). Postoperative deep sternal wound infections could be predicted by a higher BMI (p = 0.003) and leptin level (p = 0.001). Conclusions There seems to be a correlation between inflammatory processes and cardiovascular morbidity in our cohort. Further, the incidence of deep sternal wound infections is related to a higher BMI and leptin serum level.
Enhancing Adolescents' Motivation for Science: Research-Based Strategies for Teaching Male and Female Students

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Gender and trust in government modify the association between mental health and stringency of social distancing related public health measures to reduce COVID-19: a global online survey

Objectives: To investigate the associations between stringency of COVID-19 social distancing policies and mental health outcomes, and the moderating effect of trust in government and gender. Design and setting: Cross sectional study involving secondary analysis of publicly available data from a global online COVID-19 survey and the Oxford COVID-19 Government Response Tracker. Participants: 106,497 participants from 58 countries. Main outcome measures: Outcomes were a worries index and a depression index. Predictors were stringency of policies, trust in government, and gender. Multivariable regression was conducted to determine the three-way interaction between the predictor variables for mental health outcomes, adjusting for age, income and education. Results: The median age of participants (56.4% women) was 37 years (interquartile range 29 to 48 years). Women had higher worries and depression scores than men. 45.4% distrusted the government and 43.8% trusted the government to take care of its citizens. Among those who strongly trusted the government, an increase in the stringency of policies was associated with a significant increase in the worries index. Among men who distrusted the government, an increase in policy stringency was associated with an increase in the depression index but not the worries index. In women that strongly distrusted the government, there was an inversed U-shaped association between policy stringency and both the worries and depression indices. Conclusion: As the stringency of public health measures increases, so too do depression and worries. The association is moderated by gender and trust in government. For safe and effective public health measures, governments should develop strategies to increase trust in their actions.
The association between Internet Usage and Overweight/Obesity modified by Gender: Evidence from a nationally representative survey in Nepal

Objective: Using a nationally representative data, we examined the associations between internet use and overweight/obesity in people aged 15-49 years in Nepal, and the extent to which these associations vary by gender. Materials and methods: The study analyzed the nationally representative Nepal Demographic and Health Survey (NDHS) 2016 data, collected between June 2016 and January 2017. The outcome was overweight/obesity. Exposures were internet use (IU) in the last twelve months and internet use frequency (FIU) in the last month. Multivariable ordinal logistic regression models were fitted to estimate the total effects of IU and FIU on overweight/obesity adjusted for minimal sufficient adjustment set of potential confounders. P-difference was extracted using a Wald test for the models with interaction terms. Results: Of the 10,380 participants, 33.9% used internet in the last 12 months, and 13.1 % used less than/at least once in a week, and 17.5% used internet almost every day. The prevalence of overweight/obesity by IU was 38% (95% CI: 35.9%, 40.1%) for male and 44.1% (95% CI: 41.6%, 46.6) for female. The risk of overweight and obesity was significantly 1.55 times higher (aOR: 1.55; 95% CI: 1.40, 1.73; p < 0.001) among those participants who used the internet compared to the individual who did not use the internet in the last 12 months or earlier of the interview. Similar associations were observed when using the augmented measure of exposure-FIU. We observed modification effect of gender in the associations of IU (p-difference<0.001) and FIU (p-difference<0.002) with overweight and obesity in Nepal. Conclusions: Our findings suggest that it is imperative for future overweight/obesity interventions in LMICs, including Nepal, to discourage unnecessary internet use, particularly among males.
Hyphae of a vesicular—arbuscular mycorrhizal fungus maintain infectivity in dry soil, except when the soil is disturbed

SUMMARY We examined the hypothesis that hyphae of a VA mycorrhizal fungus in dry soil remain infective, but that the infectivity decreases if the soil is disturbed. We used split-pots, and sealed cylinders of nylon mesh, to create volumes of dry soil which contained hyphae of Acaulospora laevis Gerd. and Trappe that were attached, outside the mesh, to roots of living plants of Acacia satigna. (Labill.) H. Wendl. After the soil was dried in situ, the hyphae were detached from the roots without soil disturbance, or the soil containing the hyphae was disturbed. The infectivity of the hyphae after these treatments was then compared with that of intact hyphae. External hyphae of A. laevis remained highly infective in soil in which the matric potential had reached −21 MPa. Hyphae detached from the original host plant roots were equally infective. However, disturbance of the dry soil containing the external hyphae severely reduced the infectivity of the hyphae. After fluorescent staining, fungal structures with fluorescing nuclei were readily visible both within, and attached to, roots of A. Saligna which had no fluorescing nuclei.
Measuring the effectiveness of online problem-solving tutorials by multi-level knowledge transfer

This study presents a new method for assessing the effectiveness of instructional resources using online learning technology that provides much richer information than a traditional summative assessment. By requiring students to complete a sequence of problem solving and learning activities in a given order, this new method not only measures students’ ability to directly transfer learning to a new problem, but also their ability to learn from additional resources, or the “preparation for future learning” effect. We used this method to evaluate the quality of two problem solving tutorials, and found that both tutorials significantly benefit transfer to nearly identical problems, but only one facilitates transfer to a further distance. Moreover, we found evidence suggesting that one tutorial prepared students with lower prior knowledge to learn as effectively from a following worked example as students with higher prior knowledge.
'Morning Mist' Gladiolus

‘Morning Mist’, a gladiolus (Gladiolus ×hortulanus L.H. Bailey) with light-violet florets, was released in 1988 by the Univ. of Florida (Fig. 1). It combines good cut-flower characteristics, such as tall spikes with a floral bud count of 20 to 24 and the ability to open from the “tight-bud” stage, with tolerance to Fusarium oxysporum Schlect. f. sp. gladiolus Snyd. & Hans, based on field studies in Fusariuminfested soil. Fusarium has led to the demise of many lavender or violet cultivars such as ‘Beverly Ann’, ‘Lavender Spire’, and ‘T-609’, which have been grown commercially in sandy soils in central and southern Florida. Although violet-blue cultivars constitute a minor percentage of commercial gladiolus cut-flower production in the United States, they are valued for mass market and roadside sales. ‘Morning Mist’ placed fourth out of 39 seedlings in the 1981 North American Gladiolus Council (NAGC) trial gardens, evaluated at 10 locations in the United States and Canada.
Context-, phenotype-, and kin-dependent natal dispersal of barn swallows (Hirundo rustica)

Natal dispersal is a major life-history trait, with important consequences for population dynamics and genetic structure. Successful dispersal depends on a complex blend of decisions at all main stages of the dispersal process: emigration, prospection for a site, and settling. Costs and benefits of such decisions are expected to depend on sex and on the ecological context, on individual physiological state, and on concomitant decisions by relatives, which affect competition with kin and inbreeding. We analyzed natal dispersal propensity (i.e., dispersing or not) and dispersal distance in the semicolonial barn swallow (Hirundo rustica) in relation to context-, phenotype-, and kin-dependent factors. Females had larger dispersal propensity and distance than males. Dispersal propensity of both sexes was negatively density dependent and was less likely from colonies (farms) with large number of livestock, which is important to barn swallow distribution. Dispersal propensity was larger among males ranking high in the body mass brood hierarchy and smaller among late-hatched females. Dispersal distance was larger for late-hatched males and for females that ranked high in the body mass brood hierarchy. Finally, both dispersal propensity and distance of males increased with the number of male siblings. We, thus, identified several context-, phenotype-, and kin-dependent components of dispersal decisions. Phenotype-dependent effects suggest that decisions of whether to disperse and of dispersal distance are different processes under control of sex-specific traits. Finally, male dispersal behavior suggests that kin selection favors males that reduce the risk of sib–sib mating competition, in a population with male-biased tertiary sex ratio.
Relative abundance and reproductive tactics of a Loricariidae species at Saraiva Lagoon, Ilha Grande National Park, MS-PR, Brazil

This study aimed to evaluate population abundance patterns and the main events in the reproductive cycle of Loricariichthys platymetopon at Saraiva Lagoon, Ilha Grande National Park, MS-PR, Brazil. Monthly samplings were conducted from October 2004 to September 2005 in three sections of the lagoon: entrance, middle and end, which resulted in the capture of 175 individuals. Spatial and temporal variation in abundance was obtained through CPUE (number of captured individuals/1000 m2 of gillnets in 12 hours). The reproductive tactics considered were: duration, time and location of spawning, oocyte diameter and fecundity. The highest relative abundance was recorded in February, in the middle section of the lagoon, and the reproductive period lasted from September to February. The prevalence of females with spent ovaries and at rest in the following months indicated that reproductive activity ceased during autumn and winter. We observed that reproduction was high at the end section of the lagoon. The recorded mean oocyte diameter was 1.67 (SD ± 0.76) mm, mean absolute fecundity was 962.1 (SD ± 382.48) oocytes, and relative fecundity was 7.60 (SD ± 2.25) oocytes/g and 5.13 (SD ± 0.75) oocytes/cm. These tactics, probably are related to the settlement of L. platymetopom in Saraiva Lagoon, as well as in the different biotopes of the Upper Parana River floodplain.
Phytic acid and phosphorus in crop seeds and fruits: a global estimate

Abstract A very important mineral storage compound in seeds is phytate, a mixed cation salt of phytic acid (myo-inositol hexakis phosphoric acid). This compound is important for several reasons: (1) It is vital for seed/grain development and successful seedling growth. (2) It is often considered to be an antinutritional substance in human diets, but it may have a positivenutritional role as an anti-oxidant and an anti-cancer agent. (3) It represents a very significant amount of phosphorus being extracted from soilsand subsequently removed with the crop. (4) It plays a role in eutrophication of waterways. A key part of this review is an estimate of the annualtonnage of phosphorus and phytic acid sequestered in up to 4.1 billion metric tonnes of crop seeds and fruits globally each year. We estimate thatnearly 35 million metric tonnes of phytic acid, containing 9.9 million metric tonnes of P, is combined with about 12.5 and 3.9 million metric tonnes of K and Mg respectively, to form each year over 51 million metric tonnes of phytate. The amount of P inthis phytate is equal to nearly 65÷ of the elemental P sold world wide for use in mineral fertilizers. Dry cereal grains account for 69÷ of the total crop seed/fruit production but account for 77÷ of the total phytic acid stored each year. Low phytate mutants, that are now available for some key staple food crops such as maize and barley, offer potential benefits in such areas as the sustainability of lands used to grow crops, the mineral nutrition of humans and animals, and reduction in pollution of waterways.
Barley seeding rate influences the effects of variable herbicide rates on wild oat

Abstract Field experiments were conducted at Vegreville, Alberta, in 1997, 1998, and 1999 and in Lacombe, Alberta, in 1997 and 1998, to determine if barley row spacing (20 and 30 cm) and seeding rate (75, 125, and 175 kg ha−1) influenced the effects of variable tralkoxydim rates on barley seed yield, net economic returns, and wild oat seed production. In most cases, barley seed yield was unaffected by row spacing or seeding rate. Where no herbicide was applied, the presence of wild oat reduced barley yield at each location each year. When the herbicide was applied at 50, 75, or 100% of the recommended rate, barley yields were not affected by the presence of wild oat. Results were more variable at 25% of the recommended rate, especially at Lacombe, where yield losses occurred both years at this rate. The lowest net economic returns consistently occurred in the absence of herbicide application; however, the influence of herbicide rate on net returns varied among years and locations. Net returns were either higher at the lower herbicide rates or were unaffected by herbicide rate. Seeding rate and herbicide rate affected wild oat seed production at each location each year and also the amount of seeds in the soil seedbank at Vegreville in 1999. Row spacing had little or no effect on wild oat seed production. There was a consistent and highly significant seeding rate by herbicide rate interaction on wild oat seed production. The effects of tralkoxydim on wild oat seed production, especially at relatively low rates, were superior at the higher barley seeding rates. The results suggest that seeding barley at relatively high rates can result in optimum barley yields, undiminished economic returns, and effective wild oat management when tralkoxydim is used at lower than recommended rates. Nomenclature: Bromoxynil; glyphosate; MCPA; tralkoxydim; barley, ‘Falcon’, Hordeum vulgare L. ; wild oat, Avena fatua L. AVEFA.
Comparison of Solvers Performance for Load Flow Analysis

Load flow studies are carried out in order to find a steady state solution of a power system network. It is done to continuously monitor the system and decide upon future expansion of the system. The parameters of the system monitored are voltage magnitude, voltage angle, active and reactive power. This paper presents techniques used in order to obtain such parameters for a standard IEEE – 30 bus and IEEE-57 bus network and makes a comparison into the differences with regard to computational time and effectiveness of each solver