Miracle-dz/UniFAR-FTUs huggingface dataset:
Update on Prognostic and Predictive Markers in Mucinous Ovarian Cancer

Simple Summary Mucinous ovarian cancer (MOC) is a rare tumor that can be classified according to stage in early MOC and advanced MOC. Early MOC is characterized by a good prognosis and, in most cases, surgical treatment alone represents the mainstay of therapy. Despite the good prognosis, some early-stage MOCs can relapse and exhibit aggressive behavior, and new biomarkers are emerging to better stratify these patients. Advanced MOC, instead, is characterized by a poor prognosis. Radical surgery is still the mainstay of treatment since these tumors are chemo-resistant. New targeted therapies are being studied to improve the prognosis in this setting, but unfortunately, none of these have been approved yet. This review focuses on the most relevant clinical, pathological, and molecular features and treatment options according to prognosis. Abstract This review includes state-of-the-art prognostic and predictive factors of mucinous ovarian cancer (MOC), a rare tumor. Clinical, pathological, and molecular features and treatment options according to prognosis are comprehensively discussed. Different clinical implications of MOC are described according to the The International Federation of Gynecology and Obstetrics (FIGO) stage: early MOC (stage I-II) and advanced MOC (stage III-IV). Early MOC is characterized by a good prognosis. Surgery is the mainstay of treatment. Fertility-sparing surgery could be performed in patients who wish to become pregnant and that present low recurrence risk of disease. Adjuvant chemotherapy is not recommended, except in patients with high-risk clinical and pathological features. Regarding the histological features, an infiltrative growth pattern is the major prognostic factor of MOC. Furthermore, novel molecular biomarkers are emerging for tailored management of early-stage MOC. In contrast, advanced MOC is characterized by poor survival. Radical surgery is the cornerstone of treatment and adjuvant chemotherapy is recommended, although the efficacy is limited by the intrinsic chemoresistance of these tumors. Several molecular hallmarks of advanced MOC have been described in recent years (e.g., HER2 amplification, distinct methylation profiles, peculiar immunological microenvironment), but target therapy for these rare tumors is not available yet.
Attitudes toward disability among preservice special education teachers: the role of attachment style and empathy

ABSTRACT The present study was aimed at contributing to the understanding of the role of pre-service special education teachers’ attachment styles and empathy dimensions in sentiments, attitudes, and concerns towards disability. Participants were 536 pre-service special education teachers (78.4% females and 21.6% males), Results of the path analysis showed that some empathy dimensions (fantasy and personal distress) played a mediating role in the association between preoccupied and fearful attachment styles and teachers’ sentiments and concerns towards disability. Moreover, a direct positive association was reported from preoccupied attachment style to sentiments and concerns towards disability, from fantasy and personal distress (both dimensions of empathy) to sentiments towards disability, from personal distress to concerns towards disability, and from empathic concerns to attitudes towards disability, whereas negative relationships were found from perspective-taking to concerns and sentiments towards disability, as well as from empathic concern to sentiments towards disability.
Improving Genomic Prediction Accuracy in the Chinese Holstein Population by Combining with the Nordic Holstein Reference Population

Simple Summary The size of the reference population is critical to the accuracy of genomic prediction. In addition, joining the reference populations from different breeding organizations is a convenient and effective method by which to enlarge reference populations. By adding the Nordic Holstein reference population to the Chinese Holstein reference population, we found that the accuracy of genomic prediction in the Chinese Holstein population was improved substantially for the traits with high or moderate genetic correlation between the two populations; however, the low-genetic-correlation traits did not improve. These findings are important for the purposes of multi-country joint genomic evaluation. Abstract The size of the reference population is critical in order to improve the accuracy of genomic prediction. Indeed, improving genomic prediction accuracy by combining multinational reference populations has proven to be effective. In this study, we investigated the improvement of genomic prediction accuracy in seven complex traits (i.e., milk yield; fat yield; protein yield; somatic cell count; body conformation; feet and legs; and mammary system conformation) by combining the Chinese and Nordic Holstein reference populations. The estimated genetic correlations between the Chinese and Nordic Holstein populations are high with respect to protein yield, fat yield, and milk yield—whereby these correlations range from 0.621 to 0.720—and are moderate with respect to somatic cell count (0.449), but low for the three conformation traits (which range from 0.144 to 0.236). When utilizing the joint reference data and a two-trait GBLUP model, the genomic prediction accuracy in the Chinese Holsteins improves considerably with respect to the traits with moderate-to-high genetic correlations, whereas the improvement in Nordic Holsteins is small. When compared with the single population analysis, using the joint reference population for genomic prediction in younger animals, results in a 2.3 to 8.1 percent improvement in accuracy. Meanwhile, 10 replications of five-fold cross-validation were also implemented in order to evaluate the performance of joint genomic prediction, thereby resulting in a 1.6 to 5.2 percent increase in accuracy. With respect to joint genomic prediction, the bias was found to be quite low. However, for traits with low genetic correlations, the joint reference data do not improve the prediction accuracy substantially for either population.
Role of a Mixture of Polyphenol Compounds Released after Blueberry Fermentation in Chemoprevention of Mammary Carcinoma: In Vivo Involvement of miR-145

Epigenetic mechanisms such as microRNA (miRNA) deregulation seem to exert a central role in breast cancer initiation and progression. Therefore, targeting epigenetics deregulation may be an effective strategy for preventing and halting carcinogenesis. Studies have revealed the significant role of naturally occurring polyphenolic compounds derived from fermented blueberry fruits in cancer chemoprevention by modulation of cancer stem cell development through the epigenetic mechanism and regulation of cellular signaling pathways. In this study, we first investigated the phytochemical changes during the blueberry fermentation process. Fermentation favored the release of oligomers and bioactive compounds such as protocatechuic acid (PCA), gallic acid, and catechol. Next, we investigated the chemopreventive potentials of a polyphenolic mixture containing PCA, gallic acid, and catechin found in fermented blueberry juice in a breast cancer model by measuring miRNA expression and the signaling pathways involved in breast cancer stemness and invasion. To this end, 4T1 and MDA-MB-231 cell lines were treated with different doses of the polyphenolic mixture for 24 h. Additionally, female Balb/c mice were fed with this mixture for five weeks; two weeks before and three weeks after receiving 4T1 cells. Mammosphere formation was assayed in both cell lines and the single-cell suspension obtained from the tumor. Lung metastases were counted by isolating 6-thioguanine-resistant cells present in the lungs. In addition, we conducted RT-qPCR and Western blot analysis to validate the expression of targeted miRNAs and proteins, respectively. We found a significant reduction in mammosphere formation in both cell lines treated with the mixture and in tumoral primary cells isolated from mice treated with the polyphenolic compound. The number of colony-forming units of 4T1 cells in the lungs was significantly lower in the treatment group compared to the control group. miR-145 expression significantly increased in the tumor samples of mice treated with the polyphenolic mixture compared to the control group. Furthermore, a significant increase in FOXO1 levels was noted in both cell lines treated with the mixture. Overall, our results show that phenolic compounds found in fermented blueberry delay the formation of tumor-initiating cells in vitro and in vivo and reduce the spread of metastatic cells. The protective mechanisms seem to be related, at least partly, to the epigenetic modulation of mir-145 and its signaling pathways.
A quantitative analysis of factors which influence supplement use and doping among adolescent athletes in New Zealand

Objectives Doping is a maladaptive behaviour which poses numerous risks and potentially enhances athletic performance while supplement use poses threats of positive, yet inadvertent, doping control results. Investigation is required to understand factors that influence adolescent supplement use and doping in New Zealand (NZ). Design A survey was completed by 660 athletes aged 13 to 18 years, of any gender, who competed at any level of any sport in NZ. Forty-three independent variables measured autonomy, confidence sources, motivational climate, social norms and age. Methods Multivariate, ordinal, and binary logistic regression models measured associations between independent variables and five dependant variables: supplement use, doping, doping considerations and intent (soon and in the next year). Results Confidence through mastery, internally perceived locus of control (IPLOC) and volition decreased the odds of doping while confidence through self-presentation, subjective and descriptive norms increased the odds of supplement use and doping. Conclusion To decrease the odds of doping, adolescent autonomy should be increased in sport through opportunities for volitional decision making and exposure to mastery as a confidence source.
Radiation Recall Pneumonitis: The Open Challenge in Differential Diagnosis of Pneumonia Induced by Oncological Treatments

The treatment of primary and secondary lung neoplasms now sees the fundamental role of radiotherapy, associated with surgery and systemic therapies. The improvement in survival outcomes has also increased attention to the quality of life, treatment compliance and the management of side effects. The role of imaging is not only limited to recognizing the efficacy of treatment but also to identifying, as soon as possible, the uncommon effects, especially when more treatments, such as chemotherapy, immunotherapy and radiotherapy, are associated. Radiation recall pneumonitis is an uncommon treatment complication that should be correctly characterized, and it is essential to recognize the mechanisms of radiation recall pneumonitis pathogenesis and diagnostic features in order to promptly identify them and adopt the best therapeutic strategy, with the shortest possible withdrawal of the current oncological drug. In this setting, artificial intelligence could have a critical role, although a larger patient data set is required.
Examination of the positional accuracy of linear features

This research examines how the positional accuracy of linear vector data changes with feature type, complexity, percent vertex proximity and scale. In a case study, the positional accuracy of a range of linear topographic feature types across a spectrum of scales is measured by taking regular offsets to a reference line and the results are examined for relationships between positional accuracy and the aforementioned variables. It is found that positional accuracy does indeed vary with scale, feature type, complexity and percent vertex proximity.
Productivity growth and the role of mechanisation in African agriculture

ABSTRACT This paper compares agricultural productivity growth, specifically, the impact of agricultural mechanisation on total factor productivity and cereal yields, across African countries using contemporaneous and sequential Malmquist index approaches. Contemporaneous approach findings indicate that agricultural productivity grew by 1% annually over 1961–2014, while sequential technology measures show much higher growth of 1.7%. The highest growth rates were experienced since the 2000s due to technical progress. Regression analysis indicates that mechanisation, research and development, weather conditions, and population pressure influence African agricultural productivity. Climate-smart options to sustain crop yields in countries relying heavily on rain-fed agriculture are critical. The transfer of knowledge from countries with high-level productivity might enhance productivity in “laggard” countries.
CLASSES OF FUNCTIONS WITH IMPROVED ESTIMATES IN APPROXIMATION BY THE MAX-PRODUCT BERNSTEIN OPERATOR

In this paper, we find large classes of positive functions, others than those in [1], having even a Jackson-type estimate, ω1(f;1/n), in approximation by the nonlinear max-product Bernstein operator. The uniform estimate of the order O[nω1(f;1/n)2 + ω1(f;1/n)] is achieved, while near to the endpoints 0 and 1, the better pointwise estimate of the order is obtained. Finally, we prove that besides the preservation of quasi-convexity found in [1], the nonlinear max-product Bernstein operator preserves the quasi-concavity too.
Enzyme Conditioning of Chicken Collagen and Taguchi Design of Experiments Enhancing the Yield and Quality of Prepared Gelatins

During the production of mechanically deboned chicken meat (MDCM), a by-product is created that has no adequate use and is mostly disposed of in rendering plants. Due to the high content of collagen, it is a suitable raw material for the production of gelatin and hydrolysates. The purpose of the paper was to process the MDCM by-product into gelatin by 3-step extraction. An innovative method was used to prepare the starting raw material for gelatin extraction, demineralization in HCl, and conditioning with a proteolytic enzyme. A Taguchi design with two process factors (extraction temperature and extraction time) was used at three levels (42, 46, and 50 °C; 20, 40, and 60 min) to optimize the processing of the MDCM by-product into gelatins. The gel-forming and surface properties of the prepared gelatins were analyzed in detail. Depending on the processing conditions, gelatins are prepared with a gel strength of up to 390 Bloom, a viscosity of 0.9–6.8 mPa·s, a melting point of 29.9–38.4 °C, a gelling point of 14.9–17.6 °C, excellent water- and fat-holding capacity, and good foaming and emulsifying capacity and stability. The advantage of MDCM by-product processing technology is a very high degree of conversion (up to 77%) of the starting collagen raw material to gelatins and the preparation of 3 qualitatively different gelatin fractions suitable for a wide range of food, pharmaceutical, and cosmetic applications. Gelatins prepared from MDCM by-product can expand the offer of gelatins from other than beef and pork tissues.
Transformation optics on a silicon platform

Transformation optics allows the creation of innovative devices; however, its implementation in the optical domain remains challenging. We describe here our process to design and fabricate such devices using silicon as a platform for broad band operation in the optical domain. We discuss the approximations and methods employed to overcome the challenges of using dielectric materials as a platform for transformation optics, such as the anisotropy and gradient refractive index implementation. These encompass conformal and quasi-conformal mappings, and a dithering process to discretize and quantize the continuously inhomogeneous index function. We show examples of devices that we fabricated and tested, including the carpet invisibility cloak, a broad bandwidth light concentrator, and a perfect imaging device, known as Maxwell’s fish eye lens. Finally, we touch on future directions under investigation to further develop transformation optics based on dielectric materials.
Inward Bound—The Search for Supermassive Black Holes in Galactic Nuclei

Dynamical searches reveal central dark objects with masses"" 106 to 109.5 M0 in the Galaxy, M31, M32, M87, NGC 3115, NGC 3377, NGC 4258, and NGC 4594. Indirect arguments suggest but do not prove that these are supermassive black holes (BHs) like those postulated as quasar engines. This paper reviews dynam­ ical search techniques, the robustness of the evidence, and BH demographics. Stellar-dynamical evidence is generally more robust than gas-dynamical evidence (gas velocities can be nongravitational), but gas measurements reach closer to the Schwarzschild radius, and in NGC 4258 they show a Keplerian rotation curve. A statistical survey finds BHs in ""20% of nearby E-Sbc galaxies, consistent with predictions based on quasar energetics. BH masses are proportional to the mass of the bulge component. Most candidates are inactive; in some cases, the abun­ dance of fuel is not easily reconciled with BH starvation. Flashes caused by the accretion of individual stars may provide a test of the BH picture. I Visiting Astronomer, Canada-France-Hawaii Telescope (CFHT), operated by the National Research Council of Canada, Ie Centre National de la Recherche Scientifique of France, and the University of Hawaii.
Family and Individual Contexts of Middle-School Years and Educational Achievement of Youths in Middle-Aged Adulthood

Although educational development of youths can profoundly affect their other domains of health and well-being across later life trajectories, little research has investigated the prolonged effects of family and individual contexts of youths in middle-school years, a most critical developmental and formative stage, on their educational achievement in middle-aged adulthood. The current study employed data of a nationwide representative sample of middle-school youth students in the Longitudinal Study of American Youth (LSAY) to examine how grade-7 parental support for college education, family SES, and educational expectations of youths contribute to their educational achievement in adulthood of mid-thirties through their development of grade-8 academic commitment and grade-9 educational performance in terms of English, mathematics, science, and social studies grade scores. Results based on structural equation modeling of longitudinal relationship found that grade-7 parental support for college education, family SES, and educational expectations of youths had significant and direct effects on youths’ higher educational achievement in adulthood, and youths’ grade-8 academic commitment and grade-9 educational performance significantly mediated the effects of grade-7 family SES, parental support for college education, and educational expectations of youths on their educational achievement in adulthood respectively and/or concurrently. Furthermore, interaction analysis supported the promotive but not buffering effects of grade-7 educational expectations of youths by family SES on their grade-9 educational performance and educational achievement in adulthood. Implications related to the important findings of the current study pertaining to educational development of youths are discussed.
The Efficacy of Sodium-Glucose Cotransporter-2 Inhibitors in Improving Morbidity and Mortality of Heart Failure: A Systematic Review

Cardiovascular disease (CVD) is the leading cause of mortality in patients with type 2 diabetes mellitus (DM) worldwide. Sodium-glucose cotransporter-2 inhibitors (SGLT2i) were initially developed for treating patients with type 2 DM. The four major drugs developed are canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin. Apart from treating DM, these drugs have shown to have a beneficial effect on lowering cardiovascular death and lowering hospital admission, and have beneficial renal outcomes. Recently, several large-scale randomized controlled trials (RCTs) were done to assess the benefit of these drugs, mainly in patients with CVD, irrespective of their diabetic status. This systematic review examined seven large-scale randomized controlled trials that focused mainly on CVD in patients with type 2 DM and if it showed any improvement. We properly screened the RCTs if they demonstrated cardiovascular outcomes after taking the SGLT2i or a placebo drug. The seven studies combined had a total sample population of 55,433, and the mean follow-up time was about four years. The participants included in this study had various basal metabolic indices, ages, glomerular filtration rates, and diabetic status characteristics. Although these patients were quite different, after the administration of SGLT2i, the studies showed a beneficial effect in reducing CVD mortality and morbidity in patients with type 2 DM.
On the zeros of the second derivative

Suppose that f is meromorphic of finite order in the plane, and that f″ has only finitely many zeros. We prove a strong estimate for the frequency of distinct poles of f. In particular, if the poles of f have bounded multiplicities, then f has only finitely many poles.
Prevalence and Infection Intensity of Human and Animal Tungiasis in Napak District, Karamoja, Northeastern Uganda

Tungiasis is an important but highly neglected cause of morbidity in resource-poor communities in Latin America and sub-Saharan Africa. Data upon which implementation of control measures can be based are scarce. Before piloting an integrated tungiasis control program in three parishes of Napak district, Uganda, a cross-sectional survey involving the systematic examination of humans and domestic mammals was implemented to establish the occurrence patterns of tungiasis. The study population was 5482 residents, of which 4035 (73.6%) participated in the study. The prevalence of tungiasis in humans was 62.8% (95% CI: 61.3–64.3%), with slightly more males than females affected (p = 0.01). Age-specific prevalence and intensity of human tungiasis followed an S-curve pattern, with children of 5–14 years and the elderly (≥60 years) being the most affected. Half of all lesions (50%) had been manipulated by sharp objects. The prevalence of tungiasis in animals was lower (14.2%, 95% CI: 10.9–18.0) than that of humans (p < 0.001). Animal tungiasis occurred in decreasing order of frequency in pigs (80%), dogs (24%), goats (16.3%), cats (8.1%) and sheep (4.9%). In conclusion, human tungiasis was highly prevalent but animal infections were comparatively few in the study area. Nevertheless, effective control measures should be based on One Health principles.
Hydraulic geometry of straight alluvial channels and the principle of least action

Natural rivers exhibit regular hydraulic geometry relationships for which no widely accepted explanation has been given. This paper applies the physical principle of least action to the determination of stable alluvial-channel form. For steady, uniform alluvial-channel flow, both theoretical inferences and a case study show that least action occurs when the criteria of minimum potential energy and MFE (Maximum Flow Efficiency, defined here as the maximum sediment transporting capacity per unit available stream power) are satisfied. The consistency between bankfull hydraulic geometry relationships of natural channels and those of maximally efficient or 'least action' channels identified in this study demonstrates that alluvial channels commonly adjust to a maximally efficient section. Support for the use of the extremal hypotheses of maximum sediment transporting capacity and minimum stream power is provided by illustrating that they are essentially expressions of, and hence subsumed by, the more general principle of MFE.