Miracle-dz/UniFAR-FTUs huggingface dataset:
Posttraumatic growth and flourishing in the face of racial trauma.

OBJECTIVE Examining well-being in the face of racial trauma is timely, clinically significant, and severely understudied, especially in Black populations. To address this gap, we investigated the relationship between flourishing and posttraumatic growth among Black undergraduates who reported a history of racial trauma. METHOD Participants were 96 Black college students recruited from a predominantly White Midwestern university, all of whom reported experience of racial trauma. Participants completed the Flourishing Scale and Posttraumatic Growth Inventory (PTGI) in an online survey. Most were women/cisgender female/female (66.67%) and identified as religious (66%); 47% were first-generation college students. The average age of the sample was 21.14 (SD = 5.46). RESULTS We analyzed Flourishing and PTGI scores for students who were able to identify/recall a racially traumatic event/experience using linear regression. Results indicated that after controlling for sociodemographic factors, scores on the PTGI significantly predicted Flourishing scores and accounted for 29.4% of the variance. CONCLUSIONS These findings suggest that those who are able to deepen connections with others, tap into their inner strengths, gain new perspectives and a new appreciation for life, and connect to spirituality not only grow but are more likely to report flourishing. Contributing empirical evidence to the reliability (α =.91) and validity of the Flourishing Scale for Black college students, our findings also have implications for educators and clinicians interested in helping Black students grow and flourish in the aftermath of racially traumatic events. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Nociceptor Neurons Magnify Host Responses to Aggravate Periodontitis

Periodontitis is a highly prevalent chronic inflammatory disease that progressively destroys the structures supporting teeth, leading to tooth loss. Periodontal tissue is innervated by abundant pain-sensing primary afferents expressing neuropeptides and transient receptor potential vanilloid 1 (TRPV1). However, the roles of nociceptive nerves in periodontitis and bone destruction are controversial. The placement of ligature around the maxillary second molar or the oral inoculation of pathogenic bacteria induced alveolar bone destruction in mice. Chemical ablation of nociceptive neurons in the trigeminal ganglia achieved by intraganglionic injection of resiniferatoxin decreased bone loss in mouse models of experimental periodontitis. Consistently, ablation of nociceptive neurons decreased the number of osteoclasts in alveolar bone under periodontitis. The roles of nociceptors were also determined by the functional inhibition of TRPV1-expressing trigeminal afferents using an inhibitory designer receptor exclusively activated by designer drugs (DREADD) receptor. Noninvasive chemogenetic functional silencing of TRPV1-expressing trigeminal afferents not only decreased induction but also reduced the progression of bone loss in periodontitis. The infiltration of leukocytes and neutrophils to the periodontium increased at the site of ligature, which was accompanied by increased amount of proinflammatory cytokines, such as receptor activator of nuclear factor κΒ ligand, tumor necrosis factor, and interleukin 1β. The extents of increase in immune cell infiltration and cytokines were significantly lower in mice with nociceptor ablation. In contrast, the ablation of nociceptors did not alter the periodontal microbiome under the conditions of control and periodontitis. Altogether, these results indicate that TRPV1-expressing afferents increase bone destruction in periodontitis by promoting hyperactive host responses in the periodontium. We suggest that specific targeting of neuroimmune and neuroskeletal regulation can offer promising therapeutic targets for periodontitis supplementing conventional treatments.
Effect of an IMB Model-Based Education on the Acceptability of HPV Vaccination Among College Girls in Mainland China: A Cluster RCT

Objective Despite the fact that the human papillomavirus vaccine (HPVV) has been approved in mainland China since 2016, there is a lack of inoculation among Chinese college women. This multi-center, online interventional RCT based on the information-motivation-behavioral skills (IMB) model intended to investigate if the intervention may improve human papillomavirus vaccine acceptance and awareness among target women. Methods Participants were selected from comprehensive universities and allocated to 1 of 2 groups: intervention or control. After the baseline survey, participants in the intervention group were given 10-minute online IMB model-based education every day for 7 days. Self-administered questionnaire surveys on Human papillomavirus knowledge, HPVV acceptability, and IMB construct toward HPV vaccination were performed at pre- and post-intervention. Results The baseline survey was completed by 3739 female university students from the intervention (n = 1936) and control groups (n = 1803) between February and April 2020. The average score of students on 11 HPV-related questions was 5.225 ± 2.739, and only 32.07% (1199/3739) of them showed a willingness to be vaccinated against HPV. After the intervention, the intervention group had a higher willingness to vaccinate themselves and encourage their friends to get the HPVV compared to the control group (40.39% vs 31.56%, 82.67 vs 73.18%, P < .001), and the difference in knowledge scores between the 2 groups was significant (7.917 ± 1.840 vs 5.590 ± 2.859, P < .001). In addition, 8 students in the intervention group self-reported receiving HPVV during the research period. Conclusions This IMB model-based intervention showed positive effects on the participants’ knowledge, motivation, and perceived objective skills toward HPV vaccination and has the potential to improve the vaccination among Chinese college women.
Association between fatty acids and coronary heart disease: A scoping review.

INTRODUCTION High intakes of total fat are long known as a risk factor for coronary heart disease (CHD), but the association between fatty acids and CHD remains unclear. This scoping review aims to collate and analyze the association between types of fatty acid and risk of CHD. MATERIALS AND METHODS This review uses the methodological framework of Arksey and O'Malley. A total of 19 studies were selected from 9456 studies screened from the electronic databases. RESULTS Majority of the studies reported no association between saturated fat (SFA) and monounsaturated fat (MUFA) with CHD. Meanwhile, seven out of 12 studies reported inverse association between polyunsaturated fat (PUFA) and risk of CHD whilst 67% of the studies found that trans-fat intake was positively associated with CHD risk. CONCLUSIONS This review finds that all the types of dietary fat have different effects on the risk of CHD. Nevertheless, intakes of healthy fat such as MUFA and PUFA in controlled amounts are expected to reduce CHD risk. In addition, the divergence of findings found between studies might be due to the methodological inconsistencies. More robust research is needed to determine the actual dietary determinants of CHD as it will provide important information for future development of dietary intervention.
Detection of plasma complement and immune globulin in different sorts of glaucoma

Purpose To compare the plasma immune globulin and complement levels in different sorts of glaucoma to assess its association. Methods Cohort study. Plasma samples were collected from 226 normal controls and 236 glaucoma patients included 92 with acute primary angle-closure glaucoma (APACG), 76 with chronic primary angle-closure glaucoma (CPACG), 68 with primary open-angle glaucoma (POAG). 163 glaucoma patients with high intraocular pressure(IOP) was classified as a subgroup. Six indexes were analyzed: C3, C4, CH50, IgA, IgG, and IgM. Results There was a significant difference in C4, IgA, IgG, and IgM between patients with high IOP and normal controls groups(P < 0.01). TheC4 (0.27 ± 0.69 g/L), IgA (3.11 ± 1.04 g/L), IgG (12.07 ± 1.92 g/L) and IgM (1.17 ± 0.49 g/L) were higher(P < 0.05) in the high IOP groups compared with the normal controls (C4:0.25 ± 0.07 g/L, IgA: 2.54 ± 1.07 g/L, IgG: 11.21 ± 2.22 g/L, IgM:0.99 ± 0.41 g/L). There was a significant difference in age, C3, IgA, IgG, and IgM among the normal control, APACG, CPACG, and POAG. The C3 level in the APACG group (1.14 ± 0.16 g/L) was higher than normal group (1.06 ± 0.18 g/L). The IgA level was lower(P < 0.05) in the normal group (2.54 ± 1.07 g/L) compared with APACG (3.16 ± 0.97 g/L) and POAG group (2.91 ± 1.11 g/L). The IgG level of normal controls (11.21 ± 2.22 g/L) was lower (P < 0.05) than APACG group (12.15 ± 2.02 g/L) and CPACG group (11.95 ± 2.28 g/L). The IgM level was lower(P < 0.05) in the normal group (0.99 ± 0.41 g/L) compared with the APACG (1.24 ± 0.66 g/L) and CPACG group (1.17 ± 0.45 g/L). Conclusions The levels of the plasma expression of C3, IgA, IgG, IgM may be useful for discriminating the glaucoma patients and for assessing the progress of glaucoma in different sorts.
Changes in Ganglion Cell Layer Thickness after Treatment with the 0.2 µg/day Fluocinolone Acetonide Implant in Vitrectomized and Nonvitrectomized Eyes with Diabetic Macular Edema

Introduction: The objective of this study is to compare changes in ganglion cell layer (GCL) between vitrectomized and nonvitrectomized eyes with diabetic macular edema (DME) over a 2-year period following treatment with 0.2 µg/day fluocinolone acetonide (FAc) implant. Methods: Eighteen vitrectomized (group 1) and 8 nonvitrectomized (group 2) eyes were included in this cohort study. Changes in central macula GCL thickness were measured using the Spectralis spectral domain-optical coherence tomography at baseline and 6, 12, and 24 months of follow-up. Other parameters analyzed included best-corrected visual acuity (BCVA), central foveal thickness (CFT), and intraocular pressure (IOP). Results: Treatment with the FAc implant led to small reductions in mean global GCL thickness versus baseline and contrasts with the control group that was stable or slightly increased versus baseline. FAc therapy also led to improvements in mean BCVA and CFT that were observed at Month 6 and maintained to Month 24. For vitrectomized and nonvitrectomized eyes, no differences were observed between mean global GCL, BCVA, and CFT values during follow-up. Linear correlations revealed that in all groups mean BCVA at Month 24 positively correlated with mean GCL thickness at baseline and at Month 24. IOP remained stable throughout the 24 months. Conclusion: There was no evident retinal neurodegeneration in the 2-year period following treatment with FAc in both groups. GCL thickness may be a useful biomarker for assessing safety and effectiveness in patients with DME.
Cross sectional study of depression, anxiety and quality of life in glaucoma patients at a tertiary centre in North Kerala

Purpose: To determine the magnitude and direction of association of anxiety and depression and the quality of life (QoL) in persons with glaucoma. Methods: This prospective cross-sectional study in conducted in a tertiary eye center in north Kerala included glaucoma patients and normal subjects aged 40–80 years. The Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), Glaucoma Quality of Life (GQOL), and glaucoma evaluation were performed for all participants. One-way analysis of variance was used for statistical analysis. Results: The study included 148 subjects with glaucoma and 150 subjects without glaucoma. The prevalence of depression (35.81%) and anxiety (25.0%) was significantly higher in glaucoma patients. In a multivariate regression model, PHQ-9 (adjusted OR: 2.39, 95% CI: 1.31–4.38, P < 0.001), GAD-7 (adjusted OR: 2.06, 95% CI: 1.01–4.19, P = 0.01) and GQOL (coefficient: 6.92, 95% CI: 4.52–9.31, P = < 0.001) was significantly associated with glaucoma. The GAD-7 score was significantly higher (P = 0.02) in PACG compared to POAG in moderate and severe anxiety. ADL scores (one-way ANOVA, P = 0.001) and GQOL scores (one-way ANOVA, P < 0.001) were significantly associated with vision impairment and blindness. Conclusion: Depression and anxiety are common in glaucoma patients, indicating the need for screening protocols using PHQ and GAD scales to identify persons at risk. The lack of ophthalmic risk factors associated with depression and anxiety emphasizes the importance of psychological evaluation and combined management with a psychiatrist in glaucoma management.
Professional knowledge development and evidence-based practice in confusing vs. supportive work organizations: A grounded theory situational analysis of Swedish elderly care

ABSTRACT Background This article focuses on knowledge development and health professionals’ opportunities to use evidence-based practice (EBP). We studied registered physiotherapists (PT), occupational therapists (OT) and nurses (RN) in Swedish elderly-care institutions, a sector known for high turnover and shortages of competent staff. Objective To examine the perspectives of healthcare providers on professional knowledge development and EBP in their organization. Methods We conducted on-site qualitative interviews with a purposive sample of PTs, OTs and RNs, in six elderly care institutions. Situational analysis was used to analyze the material. Results Three discursive professional positions were found: 1) Professional ambition in confusing work organization; 2) Professional ambition in a knowledge-promoting work organization; and 3) Professional indifference with few aspirations for knowledge development. Professional aspirations toward knowledge development were high in two of these positions, whereas the third represents a slightly different approach with fewer aspirations for knowledge development. Linked to these professional approaches to knowledge development is a continuum of aggravating or facilitating factors within the work organization, including varying degrees of support from leadership of the organization, as well as few opportunities for rewards. Discussion and conclusions It is concluded that elderly care needs to develop strategies for evidence-based practice in order for the sector to become a sustainable arena for health professionals’ career development, and in order to improve the quality of care for the elderly.
Google Apps for Education - a powerful solution for global scientific classrooms with learner centred environment

This article provides a description of possibilities provided by Google Apps for University and K-12 education. The theoretical section is written in accordance with mathematical models of learning aimed to de velop metasystems thinking. The practical section provides the practical guidelines for application of Google Apps for Metasystems Learning Design through collaborative learning and self, peer and group assessment. The advantages of Google Apps for Educati on are discussed with regard to new learning strategy of the science, math and technology competence development. The opportunities for integrated competence based structure are provided and discussed.
Exceptional Response to Olaparib and Pembrolizumab for Pancreatic Adenocarcinoma With Germline BRCA1 Mutation and High Tumor Mutation Burden: Case Report and Literature Review

Pancreatic cancer (PC) is currently the seventh leading cause of cancer death worldwide, but is predicted to become the second leading cause of worldwide cancer death by 2030. More than 80% of patients present with locally advanced or metastatic disease, and the mainstay of treatment in this setting is systemic chemotherapy. Despite incremental advances in recent years, prognosis remains poor with a median 5-year survival rate of just 10%.
Surgical preparation and draping prior to induction of total intravenous anaesthesia.

INTRODUCTION Day surgery is increasing, making efforts to improve safe and effective patient turnover of importance. We hypothesised that the introduction of a simple protocol, dictating that anaesthesia should be induced only immediately prior to surgical incision (after surgical preparations) would lead to reduced duration of anaesthesia and postanaesthesia care unit (PACU) stay. METHODS This was a retrospective, single-centre, procedure-specific, explorative feasibility study of patients undergoing anterior cruciate ligament surgery. Timestamps were collected from the electronic patient records within a three-month period before and after introduction of the protocol at the Copenhagen University Hospital, Bispebjerg and Frederiksberg. Clinical outcomes were assessed using the PACU score, based on the modified Aldrete discharge criteria. RESULTS A total of 44 patients were included in the after-, and 74 in the before-new-protocol group. The protocol was feasible in 44/59 patients (75%). The duration of anaesthesia was significantly reduced: 113 (± 26) versus 135 (± 32), mean difference 22 (11-33) minutes, p less-than 0.001. The duration of the PACU stay was significantly reduced: 103 (± 54) versus 80 (± 35), mean difference 23 (6-40) minutes, p = 0.01. No difference was observed in clinical outcomes. CONCLUSIONS A simple protocol by which total intravenous anaesthesia was induced immediately prior to surgical incision was feasible, reduced the duration of anaesthesia and yielded a significant reduction in the PACU stay. Further studies with a randomised design are needed to confirm these preliminary findings. FUNDING departmental only. TRIAL REGISTRATION not relevant.
Digital Eyestrain and the Critical Fusion Frequency

SIGNIFICANCE Although the high prevalence of digital eyestrain has been well established, to date, there is no objective measurement of this condition. Previous studies have suggested that digital eyestrain may be associated with decreased critical fusion frequency, but the published evidence to support this association is sparse. PURPOSE This study sought to determine whether symptoms of digital eyestrain after a sustained computer task are indeed associated with changes in critical fusion frequency. METHODS The experiment was performed on 30 young visual-normal subjects. They attended two sessions, during which they undertook a 20-minute reading task. This comprised either reading random words from a tablet computer or a story from a printed children's book. Critical fusion frequency was measured both before and immediately after each of the reading tasks. In addition, the level of digital eyestrain was assessed by subjects completing a questionnaire regarding ocular and visual symptoms experienced during each of the reading trials. RESULTS The mean increase in digital eyestrain symptoms after the digital and printed conditions was 11.37 (standard error of the mean [SEM], 2.23) and 4.40 (SEM, 1.34), respectively. Both the post-task symptom change (P < .001) and the difference between the two reading conditions (P = .004) were significant. The mean change in critical fusion frequency after the digital and printed conditions was −0.42 (SEM, 0.25) and −0.72 (SEM, 0.26), respectively. Neither the post-task change nor the difference between the two reading conditions was significant. In addition, when considering the digital condition only, no significant correlation was observed between the changes in critical fusion frequency and reported symptoms. CONCLUSIONS These results do not support the proposal that changes in critical fusion frequency can be used as an objective measure of eyestrain or other symptoms of digital eyestrain.
Performance of Pediatric Neuroradiologists Working from Home during a Pandemic at a Quaternary Pediatric Academic Hospital

BACKGROUND AND PURPOSE: As a result of the coronavirus disease 2019 (COVID-19) pandemic, many radiology departments shifted to working a portion of clinical assignments from home. To determine the effect of working from home on performance, productivity, quality, and safety, we evaluated turnaround time, volume of studies, and error rates on rotations worked from home compared with in the hospital. MATERIALS AND METHODS: The number of studies interpreted per day for each neuroradiologist, turnaround times, and error rates reported to peer learning was identified from April 1, 2020, through September 30, 2020. For each neuroradiologist, mean turnaround times and volumes per day at home versus in the hospital were compared. Similar comparison was performed for STAT studies. RESULTS: During the time period, 2597 CTs (1897 at home, 700 in the hospital) and 3685 MRIs (2601 at home, 1084 in the hospital) were read. By individual neuroradiologists, 57% (4/7) had shorter turnaround time at home and 57% (4/7) demonstrated an increase in the mean number of studies per day read at home. No statistically significant difference was noted in the neuroradiologists’ performance while reading STAT studies. Reported error rates were not found to be higher at home, with statistically significantly lower rates when working at home (P = .018). CONCLUSIONS: Variable productivity and performance of neuroradiologists when working from home versus in the hospital were found, being 57% faster and/or more productive while working at home without an increase in error rates. The decision to work at home versus in the hospital may best be based on local factors, balancing the variability among individual neuroradiologist’s and the institution’s needs, recognizing that working from home is not a one-size-fits-all phenomenon but requires adaptability for successful implementation.
Psychiatric disorders among children with acute lymphoblastic leukemia in South Korea: a nationwide population-based longitudinal study

Objective Children with acute lymphoblastic leukemia (ALL) may be at increased risk of psychiatric disorders. This study analyzed the incidence of psychiatric disorders in children with ALL in South Korea. Methods Using nationwide claims data for January 2009 to March 2016, we identified three major psychiatric disorders (depression, anxiety and stress/adjustment disorder) among children diagnosed with ALL. We analyzed the incidence of psychiatric disorders before and after ALL diagnosis. Results Overall, 2160 children diagnosed with ALL were identified. Seventy-five children (3.5%) were diagnosed with at least one major psychiatric disorder from 1 year before ALL diagnosis to the last follow-up point (range: 42.5–111.5 months). Of these, 70 (93.3%) patients were identified after ALL diagnosis, with the incidence peaking 1 year after ALL diagnosis. Depression, anxiety and stress/adjustment disorders were diagnosed in 30 (1.4%), 15 (0.7%) and 30 (1.4%) patients, respectively. Conclusions Among pediatric patients with ALL, most psychiatric disorders were identified after the diagnosis of leukemia, and psychiatric disorder incidence differed according to patient age and time since ALL diagnosis. Timely screening for and proper management of mental disorders are needed during all stages of ALL treatment.