Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioactive secondary metabolites in sea cucumbers and their potential
 to use in the functional food industry

The bioactive secondary metabolites produced by sea cucumbers are very diverse with differences in composition, linkages, molecular weight, and various functional properties. Due to their physicochemical properties, these bioactive molecules in sea cucumbers have found applications in various market segments such as functional foods and cosmetics. Sea cucumber side dishes are a prominent food item in traditional cuisine in East Asian countries such as South Korea, China, and Japan. In addition, many studies have reported that the consumption of sea cucumbers can reduce the risk of cardiovascular disease, the pathogenesis of cancer cells, chronic inflammatory diseases, etc. In particular, many studies have recently reported the potential of sea cucumbers to develop functional products to reduce inflammation, oxidative stress, diabetes, and cancer. Additionally, these bioactive properties associated with sea cucumbers make them ideal compounds for use as functional ingredients in functional food products. However, no report has yet reviewed the properties of sea cucumbers related to functional foods. Therefore, in this review, the primary focus is given to collecting published scientific data (from 2019 to 2023) on the bioactive properties of sea cucumbers relevant to the functional food industry.
Turbulent free convection in a vertical slot

This paper is a continuation of the experimental study (Elder 1965), of free convection in a vertical slot, to unsteady and turbulent motion. The flow is specified by three dimensionless parameters: σ, the Prandtl number; h = H|L, the aspect ratio and $A = \gamma g \Delta TL^3|kv$, the Rayleigh number. The present experiments are generally for σ = 7 (water), h = 10–30 and A > 106. For A above about 8 × 108S|h3, travelling, wave-like motions grow up the hot wall of the slot and also down the cold wall. These waves grow most readily mid-way between the two ends. At higher values of the Rayleigh number when the wave amplitude is finite, the phase of successive wave fronts becomes increasingly random till near A = 1·0 × 1010|h3 an intense entrainment and mixing process commences between the wall region and the interior. The middle portion of the interior is then turbulent, the extent of the region growing further toward the ends as A increases. Measurements of the mean temperature and the probability distribution of temperature fluctuations of the turbulent flow are reported. Except within the thin wall layers and distant form the ends, the interior has a mean temperature, uniform to within 0·1%, superimposed on which is a nearly Gaussian fluctuation-field of variance of order 0·01ΔT. A comparison is made with recent theories of turbulent convection; moderate agreement is found with the similarity ideas of Priestley (1959). The wall layer is seen as a marginally unstable sublayer.
Plains Tectonism on Venus: Inferences from Canali Longitudinal Profiles

Abstract Canali-type channels on Venus show inverted profile segments; that is, large portions of the channels trend uphill. The original gradients for these channels were not horizontal, but must have progressively trended downhill. Therefore, undulation patterns imposed on the profiles have to be the result of tectonism occurring since channel formation. This implies that some of the uppermost geological units of the plains, which are coincident with canali, experienced significant postemplacement tectonic deformation. The pattern of deformation is hierarchical. Within observational limits, at least two scales of deformation are indicated. The longer scale deformation (thousands of kilometers) corresponds to largescale basins; the shorter scale deformation (hundreds of kilometers) corresponds to ridge belts or to small-scale domes/basins. The latter features, at scales up to a few hundred kilometers, extensively deform some plains areas. Although not appearing in the topographic profiles because of resolution limitations, deformation scales of tens of kilometers or less, which mostly reflect wrinkle ridges, also overlap the longer deformation scales. The channels probably formed relatively quickly in comparison to the time scale of deformation. Canali formation is closely related to the genesis of plains, and canali profile deformation reflects tectonic processes operating at multiple scales. The lower limit rates of large-scale tectonic warping are comparable to epeirogenetic deformation rates for Earth's intraplate continental interiors.
Systematics of Lepidocyrtinusboneti Denis, 1948 (Collembola, Seirinae) reveals a new position for the species within Seirinae

﻿Abstract Seiraboneti Denis, 1948, comb. nov. is examined and redescribed based on syntypes and by a newly discovered Chinese population. Lectotype and paralectotypes were designated, and the type locality of the species has been fixed to Câuda, near Nhatrang, Vietnam. The species was first described in the genus Lepidocyrtinus, but based on morphological and molecular evidence it is here transferred to Seira. For the phylogenetic placement of Seiraboneticomb. nov., its mitogenome was included in a dataset comprising 19 species of Seirinae. Maximum Likelihood and Bayesian inferences clustered the species next to Seirasanloemensis Godeiro & Cipola, 2020 from Cambodia, forming a distinct Seira clade from the Old World, confirming the hypothesis of the existence of a different basal lineage of Seirinae in Southern Asia.
Graviton scattering in self-dual radiative space-times

The construction of amplitudes on curved space-times is a major challenge, particularly when the background has non-constant curvature. We give formulae for all tree-level graviton scattering amplitudes in curved self-dual (SD) radiative space-times; these are chiral, source-free, asymptotically flat spaces determined by free characteristic data at null infinity. Such space-times admit an elegant description in terms of twistor theory, which provides the powerful tools required to exploit their underlying integrability. The tree-level S-matrix is written in terms of an integral over the moduli space of holomorphic maps from the Riemann sphere to twistor space, with the degree of the map corresponding to the helicity configuration of the external gravitons. For the MHV sector, we derive the amplitude directly from the Einstein–Hilbert action of general relativity, while other helicity configurations arise from a natural family of generating functionals and pass several consistency checks. The amplitudes in SD radiative space-times exhibit many novel features that are absent in Minkowski space, including tail effects. There remain residual integrals due to the functional degrees of freedom in the background space-time, but our formulae have many fewer such integrals than would be expected from space-time perturbation theory. In highly symmetric special cases, such as SD plane waves, the number of residual integrals can be further reduced, resulting in much simpler expressions for the scattering amplitudes.
Analysis of the molecular and biochemical mechanisms involved in the symbiotic relationship between Arbuscular mycorrhiza fungi and Manihot esculenta Crantz

Introduction Plants and arbuscular mycorrhizal fungi (AMF) mutualistic interactions are essential for sustainable agriculture production. Although it is shown that AMF inoculation improves cassava physiological performances and yield traits, the molecular mechanisms involved in AM symbiosis remain largely unknown. Herein, we integrated metabolomics and transcriptomics analyses of symbiotic (Ri) and asymbiotic (CK) cassava roots and explored AM-induced biochemical and transcriptional changes. Results Three weeks (3w) after AMF inoculations, proliferating fungal hyphae were observable, and plant height and root length were significantly increased. In total, we identified 1,016 metabolites, of which 25 were differentially accumulated (DAMs) at 3w. The most highly induced metabolites were 5-aminolevulinic acid, L-glutamic acid, and lysoPC 18:2. Transcriptome analysis identified 693 and 6,481 differentially expressed genes (DEGs) in the comparison between CK (3w) against Ri at 3w and 6w, respectively. Functional enrichment analyses of DAMs and DEGs unveiled transport, amino acids and sugar metabolisms, biosynthesis of secondary metabolites, plant hormone signal transduction, phenylpropanoid biosynthesis, and plant-pathogen interactions as the most differentially regulated pathways. Potential candidate genes, including nitrogen and phosphate transporters, transcription factors, phytohormone, sugar metabolism-related, and SYM (symbiosis) signaling pathway-related, were identified for future functional studies. Discussion Our results provide molecular insights into AM symbiosis and valuable resources for improving cassava production.
On the large sieve

The purpose of this paper is to give a new and improved version of Linnik's large sieve, with some applications. The large sieve has its roots in the Hardy-Littlewood method, and in its most general form it may be considered as an inequality which relates a singular series arising from an integral where S (α) is any exponential sum, to the integral itself.
SUR LA THÉORIE SPECTRALE DES RELATIONS D’ÉQUIVALENCE MESURÉES

Nous présentons une étude des relations d’équivalence mesurées du point de vue spectral. En particulier nous montrons que pour une relation d’équivalence donnée, la propriété T de Kazhdan, l’ergodicité forte et la moyennabilité peuvent être caractérisées par la présence d’un trou dans le spectre de certaines marches aléatoires sur les orbites de cette relation (à coefficients dans des représentations hilbertiennes appropriées). Les démonstrations reposent de façon essentielle sur l’étude des relations d’équivalence moyennables (Connes–Feldman–Weiss), sur les caractérisations spectrales correspondantes, pour les groupes dénombrables, de la moyennabilité (théorème de Kesten) et de la propriété T de Kazhdan (Gromov, Ghys, etc.), ainsi que sur des résultats techniques sur les représentations unitaires de relations d’équivalence mesurées (en particulier au voisinage de la représentation triviale) que nous développons au cours de l’article. Enfin nous obtenons un analogue du “critère $\lambda_1>1/2$” pour les relations d’équivalence mesurées. It is a well known theorem due to Kesten that amenability for discrete groups can be characterized in terms of the spectra of diffusion operators associated to random walks on the Cayley graph of these groups. In this paper we are interested in analogous results in the framework of discrete measured equivalence relations. Our main results concern characterizations of Kazhdan’s property T, amenability, and the non existence of amenable quotients (strong ergodicity), in terms of the spectra of diffusion operators associated to random walks and hilbertian representations of the underlying equivalence relation. Our arguments are based on the proof of Connes–Feldman–Weiss’s classification of amenable equivalence relations, the spectral characterizations, in the group case, of amenability (Kesten) and property T (Gromov, Ghys, etc.), as well as new results on the representation theory of measured equivalence relations (in particular in the neighbourhood of the trivial representation) and Kazhdan’s property T. As an application we show how Żuk’s ‘$\lambda_1>1/2$’ criterion for property T can be adapted to measured equivalence relations.
Overshoot of the Respiratory Exchange Ratio during Recovery from Maximal Exercise Testing in Young Patients with Congenital Heart Disease

Introduction: The overshoot of the respiratory exchange ratio (RER) after exercise is reduced in patients with heart failure. Aim: The present study aimed to investigate the presence of this phenomenon in young patients with congenital heart disease (CHD), who generally present reduced cardiorespiratory fitness. Methods: In this retrospective study, patients with CHD underwent a maximal cardiopulmonary exercise testing (CPET) assessing the RER recovery parameters: the RER at peak exercise, the maximum RER value reached during recovery, the magnitude of the RER overshoot and the linear slope of the RER increase after the end of the exercise. Results: In total, 117 patients were included in this study. Of these, there were 24 healthy age-matched control subjects and 93 young patients with CHD (transposition of great arteries, Fontan procedure, aortic coarctation and tetralogy of Fallot). All patients presented a RER overshoot during recovery. Patients with CHD showed reduced aerobic capacity and cardiorespiratory efficiency during exercise, as well as a lower RER overshoot when compared to controls. RER magnitude was higher in the controls and patients with aortic coarctation when compared to those with transposition of great arteries, previous Fontan procedure, and tetralogy of Fallot. The RER magnitude was found to be correlated with the most relevant cardiorespiratory fitness and efficiency indices. Conclusions: The present study proposes new recovery indices for functional evaluation in patients with CHD. Thus, the RER recovery overshoots analysis should be part of routine CPET evaluation to further improve prognostic risk stratifications in patients with CHD.
Tricuspid Valve Regurgitation in Hypoplastic Left Heart Syndrome: Current Insights and Future Perspectives

Hypoplastic Left Heart Syndrome (HLHS) is a congenital heart defect that requires a three-stage surgical palliation to create a single ventricle system in the right side of the heart. Of patients undergoing this cardiac palliation series, 25% will develop tricuspid regurgitation (TR), which is associated with an increased mortality risk. Valvular regurgitation in this population has been extensively studied to understand indicators and mechanisms of comorbidity. In this article, we review the current state of research on TR in HLHS, including identified valvular anomalies and geometric properties as the main reasons for the poor prognosis. After this review, we present some suggestions for future TR-related studies to answer the central question: What are the predictors of TR onset during the three palliation stages? These studies involve (i) the use of engineering-based metrics to evaluate valve leaflet strains and predict tissue material properties, (ii) perform multivariate analyses to identify TR predictors, and (iii) develop predictive models, particularly using longitudinally tracked patient cohorts to foretell patient-specific trajectories. Regarded together, these ongoing and future efforts will result in the development of innovative tools that can aid in surgical timing decisions, in prophylactic surgical valve repair, and in the refinement of current intervention techniques.
Primary Closure vs T-Tube Drainage Following Open Choledochotomy for CBD (Common Bile Duct) Stones

Background: Choledocholithiasis affects 10%-15% of individuals with gallbladder stones. Approximately 7%-15% of cholecystectomy patients develop common bile duct (CBD) stones. It occurs more frequently in older age groups. It may result in a complete or partial blockage of the bile duct and present as pancreatitis or cholangitis due to gallstones. Objective: The aim of this study was to compare the outcomes of primary closure of duct and T-tube drainage after open choledochotomy and to evaluate the effectiveness and safety of primary closure. Material and methods: From January 2018 to December 2021, this descriptive study was carried out in the surgical department of the Hayatabad Medical Complex in Peshawar. In total, 60 patients who had open choledocholithotomy after a failed endoscopic extraction were included in this study. Of these, 30 (50%) patients got primary duct closure after choledochotomy, while 30 (50%) patients had T-tube insertion. Results: Among the total of 60 patients (primary closure: 30 and T-tube drainage: 30 patients), 10 (16%) were males, while 50 (84%) were female patients. The mean age was recorded as 45.9±13.9, and the mean hospital stay in days in both groups was 4.87±1.4 (T-tube: 5.24±1.50 and primary closure: 4.50±1.3). Complications developed in group A were a biliary leak in three (10%) patients, postoperative jaundice in two (6.5%) patients, wound infection in three (10%), intra-abdominal collection in three (10%) patients, and dislodgement of a tube in two (6.5%), while 17 (57%) patients had no complications developed. Conclusion: If the duct is free of stones, as determined by preoperative choledochoscopy, primary closure of the common bile duct (CBD) is a safe, cost-effective procedure with less morbidity than regular T-tube drainage after open choledochotomy.
The Galerkin-averaging method for nonlinear, undamped continuous systems

The analysis of initial-boundary value problems for nonlinear evolution equations with a small parameter is carried out by projection and averaging. The complications of the extension to a second order approximation is discussed and subsequently demonstrated for the perturbed Klein-Gordon equation. The difference between the case of resonance and nonresonance at first order is emphasized.
2-neighborhoods and Hamiltonian conditions

In terms of local properties of 2-neighborhoods (sets of vertices at distance 2 from a vertex or a subgraph), new sufficient conditions for a graph to be hamiltonian are obtained. In particular, results of Fan and Chavatal and Erdos are generalized. The new results also apply to graphs with larger diameter.
Vortical structures on three-dimensional shock control bumps

Three-dimensional shock control bumps have long been investigated for their promising wave drag reduction capability. However, a recently emerging application has been their deployment as “smart” vortex generators, which offset the parasitic drag of their vortices against their wave drag reduction. It is known that three-dimensional shock control bumps produce streamwise vortices under most operating conditions; however, there have been very few investigations that have aimed to specifically examine the relevant flow structures. In particular, the strength of the vortices produced as well as the factors influencing their production are not well known. This paper uses a joint experimental and computational approach to test three different shock control bump shapes, categorizing their flow structures. Four common key vortical structures are observed, predominantly shear flows, although all bumps also produce a streamwise vortex pair. Both cases with and without flow separation on the bump tails are scrutini.
Managerial concentration, ownership concentration, and firm value: Evidence from Spanish SMEs

Various corporate governance theories indicate that governance in small and medium-sized enterprises (SMEs) differs to that of larger corporations due to the ownership-management function within the organizational structure. This article provides empirical evidence of enhanced firm value in a sample of listed SMEs resulting from certain corporate governance mechanisms related to managerial and ownership concentration. The empirical analysis conducted in this paper is based on a panel data set consisting of 108 small and medium-sized public firms on the Spanish alternative stock exchange over a time frame of five years (2015-2019). The results suggest that CEO duality, the controlling shareholders, and the second largest shareholders all improve firm value. Conversely, the ratio of independent directors has a negative impact on firm value. These findings are robust to alternative model specifications such as dynamic panel estimators (Generalized Method of Moments -GMM-) and instrumental variable methods. Overall, we show that the governance configuration of listed SMEs can mitigate several of the central issues, such as agency problems, that large corporations face.
Intraseasonal Oscillation in the Indian Summer Monsoon Simulated by Global and Nested Regional Climate Models

Abstract Simulations of the intraseasonal oscillation (ISO) in the Indian summer monsoon by a general circulation model (GCM) and a nested regional climate model (RCM) are described. The ISO is the leading mode of subseasonal variability in both models. It is shown to be associated with circulation and precipitation anomalies that propagate northward from the equatorial Indian Ocean to the foothills of the Himalayas on the 30–50-day timescale. The spatial structure, timescale, and propagation characteristics of the simulated ISO are found to be similar to those of the leading observed intraseasonal mode. In particular, both of the simulated versions and the observed version all involve periodic deepening and filling of the monsoon trough resulting from northward propagation of troughs and ridges from the equatorial region. Some differences do occur, however: the GCM version of the ISO is too zonally symmetric and the ISO is too strong in both models. During the positive phase of the ISO (i.e., when the IS.
Effect of Self-Chosen Music in Alleviating the Burden on Family Caregivers of Patients with Advanced Cancer: A Randomised Controlled Trial

The experience of caregiver burden among family members of patients with advanced cancer is a common problem. The aim of this study was to determine whether the burden may be alleviated by means of a therapeutic approach based on self-chosen music. This randomised controlled trial (ClinicalTrials.gov, NCT04052074. Registered 9 August 2019) included 82 family caregivers of patients receiving home palliative care for advanced cancer. The intervention group (n = 41) listened to pre-recorded, self-chosen music for 30 min/day for seven consecutive days, while the control group (n = 41) listened to a recording of basic therapeutic education at the same frequency. The degree of burden was assessed by the Caregiver Strain Index (CSI), calculated before and after the seven-day intervention. According to this measure, caregiver burden fell significantly in the intervention group (CSI change: −0.56, SD 2.16) but increased in the control group (CSI change: +0.68, SD 1.47), with a significant group x moment interaction F(1, 80) = 9.30, p = 0.003, η2p = 0.11. These results suggest that, in the short term at least, the use of therapy based on self-chosen music alleviates the burden on family caregivers of palliative cancer patients. Moreover, this therapy is easy to administer at home and does not present any problems in practice.
A generalized orthotropic hyperelastic material model with application to incompressible shells

In the present paper a new orthotropic hyperelastic constitutive model is proposed which can be applied to the numerical simulation of a wide range of anisotropic materials and particularly biological soft tissues. The model represents a non‐linear extension of the orthotropic St. Venant–Kirchhoff material and is described in each principal material direction by an arbitrary isotropic tensor function coupled with the corresponding structural tensor. In the special case of isotropy this constitutive formulation reduces to the Valanis–Landel hypothesis and may therefore be considered as its generalization to the case of orthotropy. Constitutive relations and tangent moduli of the model are expressed in terms of eigenvalue bases of the right Cauchy–Green tensor C and obtained for the case of distinct and coinciding eigenvalues as well. For the analysis of shells the model is then coupled with a six (five in incompressible case) parametric shell kinematics able to deal with large strains as well as finite rotations. The application of the developed finite shell element is finally illustrated by a number of numerical examples. Copyright © 2001 John Wiley & Sons, Ltd.