Miracle-dz/UniFAR-FTUs huggingface dataset:
Syncing fault rock clocks: Direct comparison of U-Pb carbonate and K-Ar illite fault dating methods

The timing of slip on brittle faults in Earth’s upper crust is difficult to constrain, and direct radiometric dating of fault-generated materials is the most explicit approach. Here we make a direct comparison between K-Ar dating of fault gouge clay (authigenic illite) and U-Pb dating of carbonate slickenfibers and veins from the same fault. We have dated fault generated materials from the Big Creek fault, a northwest-striking, dextral strike-slip fault system in Yukon Territory, Canadian Cordillera. Both methods yielded dates at ca. 73 Ma and ca. 60–57 Ma, representing at least two periods of fault slip that form part of a complex fault and fluid-flow history. The Cretaceous result lies within previous indirect estimates for major slip on the fault. The Paleocene–Eocene result coincides with the estimated timing of slip of the nearby Tintina and Denali faults, which are crustal-scale, northwest-striking dextral faults, indicating Big Creek fault reactivation during regional faulting. The coincidence of periods of carbonate-crystallizing fracturing and fluid flow with intervals of seismic, gouge-generating slip supports the fault valve model, where fault strength is mediated by fluid pressures, and fluid emplacement requires seismic pumping in otherwise impermeable aseismic fault zones. The reproducibility of slip periods for distinct fault-generated materials using different decay systems indicates that these methods provide complimentary results and can be reliably applied to date brittle fault slip, opening new opportunities for investigating fault conditions with associated mineralizing fluid events.
Electron irradiation-induced amorphism of some silicates

Abstract Irradiation with 200 keV electrons induced amorphism in natural beryl and cordierite, at fluences of ∼ 1026e/m2, a factor of ≈ 10 times that required to produce a similar effect in quartz. After dehydration of the beryl and cordierite by heating at 1050°C, the fluence required to induce amorphism was increased to ∼ 1027e/m2. The electron fluence required to produce amorphism in both materials decreased with decreasing electron energy, as expected if solid-phase radiolysis is responsible. CsAlSi5O12, prepared by dry-firing ceramic techniques, was rendered amorphous at a fluence of 3 × 1024 e/m2 (E = 200 keV). However, there was little apparent dependence of the electron fluence required to produce amorphism on electron energy over the 50–200 keV range, and Cs+ migration may play a critical role in the crystalline ← amorphous transformation. A natural sphene was unaffected structurally by irradiation to a fluence of 2 × 1027 e/m2 (E = 200 keV). The data are consistent with established theories that.
Local Earthquake Tomography at Los Humeros Geothermal Field (Mexico)

A passive seismic experiment using 25 broadband and 20 short‐period stations was conducted between September 2017 and September 2018 at Los Humeros geothermal field, an important natural laboratory for superhot geothermal systems in Mexico. From the recorded local seismicity, we derive a minimum 1‐D velocity model and obtain 3‐D Vp and Vp/Vs structures of Los Humeros. We improved the classical local earthquake tomography by using a postprocessing statistical approach. Several inversions were computed and averaged to reduce artifacts introduced by the model parametrization and to increase the resolution of the investigated region. Finally, the resulting Vp and Vp/Vs structures and associated seismicity were integrated with newly acquired geophysical and petrophysical data for comprehensive interpretation. The recorded seismicity is mainly grouped in three clusters, two of which seem directly related to exploitation activities. By combining new laboratory measurements and existing well data with our Vp model, we estimate possible geological unit boundaries. One large intrusion‐like body in the Vp model, together with neighboring high Vp/Vs anomalies, hints at a region of active resurgence or uplift due to the intrusion of new magma at the northern portion of the geothermal field. We interpret high Vp/Vs features as fluid bearing regions potentially favorable for further geothermal exploitation. Deep reaching permeable faults cutting the reservoir unit could explain fluid flow from a deeper local heat source in the area.
Is value statement an effective informal control for stimulating pro-environmental behaviors?

This study aimed to examine when and how a pro-environmental value statement is effective at stimulating pro-environmental behavior. Specifically, it examines whether the effect of pro-environmental value statements on pro-environmental behavior depends on participation in goal setting and whether that effect is explained by goal commitment. Few recent empirical studies examine the behavioral effects of value statements, despite the potential of this informal control to stimulate appropriate behaviors. Also scarce are studies on management control examining the effects of different types of control on pro-environmental behavior. Pro-environmental behaviors are important in the business environment as they promote a reduction in pollutants and contribute to the effective design of environmental management systems and to environmental performance. Thus, it is important to identify how management control mechanisms can promote or inhibit this type of behavior. The contribution to the management control literature is to show in which context and through which process value statements can be an effective informal control. In addition, the practical implication is that decentralized organizations can benefit from the use of value statements as a control mechanism, providing they enable participation in goal setting. Participants were recruited via the Amazon Mechanical Turk platform and they had to decide about compliance with an environmental agreement in an experimental study. I manipulate the presence of a pro-environmental value statement and the participation in setting the profit goal. Research findings indicate that a pro-environmental value statement reduces commitment to the profit goal and thus increases environmental compliance, but only when the goal-setting is participative. When the goal-setting is imposed, a pro-environmental value statement does not affect commitment and environmental compliance. The main contribution is to indicate that decentralized organizations can stimulate appropriate behaviors by communicating prioritized values through a value statement when participation in goal setting is allowed.
Clinicopathological study of gall bladder carcinoma with special reference to its management in a tertiary care hospital

Background: Incidence of gallbladder carcinoma is increasing progressively among Indians and is regarded as a major cause of mortality and morbidity. In spite of this, limited studies have been conducted so far. Objective of the study was to know the prevalence, clinicopathological aspects, and prevalent treatment protocol of gall bladder cancer in a tertiary care hospital in Eastern India. Methods: 64 cases of histologically proven gallbladder cancer patients were studied. Patient characteristics were recorded using pretested proforma along with relevant investigations, and histopathology and treatment provided were recorded. Results: Our study reveals that gallbladder cancer has a prominent peak in the 7th decade of life with male: female ratio of 1:2.2. Most of the patients were having body mass index between 20.0 and 24.99, which is in sharp contrast to the available literatures. Pain is the most common symptom followed by constitutional symptoms. Majority of cases presented at advanced stage (64.1%) with significantly elevated CA19.9 level, and were managed with palliative chemotherapy.35. 9% of our cases were respectable at the time of diagnosis, and extended cholecystectomy could be performed in 31.3%. Log rank test showed pattern of survival of the patients who were resected was significantly better than those of who were not resected. Conclusions: We know gallbladder cancer is a disease with very few patients amenable to surgery at the time of presentation. Thus, instead of retrospectively analyzing individual institutional data, high volume institutions with the necessary expertise for treating gallbladder cancer should collaborate with a view of generating strong evidence-based surgical guidelines.
CFC‐11, Δ14C and 3H tracers as a means to assess anthropogenic CO2 concentrations in the ocean

Since anthropogenic CO 2 concentrations in the ocean cannot be measured, it is very difficult to assess the accuracy of the various estimates. Until now, only comparisons among the various approaches and hypotheses have been used to estimate the uncertainties of the results. Here we use three measured anthropogenic tracers (CFC-11, Δ 14 C and 3 H) to assess the relevance of three estimates of anthropogenic CO 2 distributions based upon very different hypotheses. In order to focus this work on the correlations among tracers and estimates of anthropogenic CO 2 concentrations in the ocean, we chose as an example the data set from the WOCE I1 cruise (Indian Ocean; 1995), since it included data from the three tracers as well as data of the carbonate/CO 2 properties. This choice further allows us to use the published results of anthropogenic CO 2 concentrations using both the ΔC* and MIX approaches. Using four properties (total dissolved inorganic carbon, total alkalinity, dissolved oxygen and potential temperature) of this data set, we also estimated the distribution of anthropogenic CO 2 using the recent TrOCA approach. The results of correlations of anthropogenic CO 2 concentrations with the anthropogenic tracers 3 H, CFC-11 and Δ 14 C, indicate that these correlations are significantly higher when anthropogenic CO 2 is estimated using either the MIX or the TrOCA approaches than using the ΔC* approach. Based upon these results and the easiness to use the simple TrOCA approach we propose to use this method to unravel the distribution of anthropogenic carbon in the Ocean. DOI: 10.1111/j.1600-0889.2006. 00247.x
Bacterial Multidrug Resistant Patterns Associated with Intensive Care Unit Infections in Akum, Cameroon

Background: Patients admitted into the intensive care unit (ICU) usually have impaired immunity and are therefore at high risk of acquiring hospital associated infections. Infections caused by multidrug resistant bacteria now constitute a major problem, limiting the choice of antimicrobial therapy. Objectives: This study was aimed at determining the antimicrobial resistance pattern of pathogens causing ICU infections at the Catholic Holy Family Hospital Akum-Bamenda. The etiological agents, prevalence and types ICU infections were also determined. Methods: Thirteen months hospital associated infections surveillance was conducted in the hospital for patients admitted into ICU. Blood, urine, tracheal aspirate and wound biopsies specimens were collected under strict asepsis and sent to the Medical Microbiology laboratory of the same institution for immediate processing. All pathogens were isolated and identified by standard microbiological methods. Disk diffusion antibiotic susceptibility testing was performed and interpreted according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: The overall prevalence of ICU infections was 30.9% out of which 12.9% were bloodstream infections, 31.5% urinary tract infections, 38.9% pneumonia, and 16.7% skin and soft tissue infections. Klebsiella species and Escherichia coli were the predominant pathogens. Multidrug resistant organisms constituted 59.3% of the pathogens, MDR Klebsiella spp and MDR E. coli were 70.8% and 71.4% respectively. Resistance to Cefuroxime was the highest (92.9%) while Meropenem had the least resistance (21.4%). Conclusion: There is a high prevalence of multidrug resistant bacteria causing ICU infections. With the advent of covid-19, infection control procedures and institution of functional antimicrobial stewardship are needed to be put in place in order to cover come this herculean task.
Measuring N2O Emissions from Multiple Sources Using a Backward Lagrangian Stochastic Model

Nitrous oxide (N2O) emissions from agricultural soil are substantially influenced by nitrogen (N) and field management practices. While routinely soil chambers have been used to measure emissions from small plots, measuring field-scale emissions with micrometeorological methods has been limited. This study implemented a backward Lagrangian stochastic (bLS) technique to simultaneously and near-continuously measure N2O emissions from four adjacent fields of approximately 1 ha each. A scanning open-path Fourier-transform infrared spectrometer (OP-FTIR), edge-of-field gas sampling and measurement, locally measured turbulence, and bLS emissions modeling were integrated to measure N2O emissions from four adjacent fields of maize production using different management in 2015. The maize N management treatments consisted of 220 kg NH3-N ha−1 applied either as one application in the fall after harvest or spring before planting or split between fall after harvest and spring before planting. The field preparation treatments evaluated were no-till (NT) and chisel plow (ChP). This study showed that the OP-FTIR plus bLS method had a minimum detection limit (MDL) of ±1.2 µg m−2 s−1 (3σ) for multi-source flux measurements. The average N2O emission of the four treatments ranged from 0.1 to 2.3 µg m−2 s−1 over the study period of 01 May to 11 June after the spring fertilizer application. The management of the full-N rate applied in the fall led to higher N2O emissions than the split-N rates applied in the fall and spring. Based on the same N application, the ChP practice tended to increase N2O emissions compared with NT. Advection of N2O from adjacent fields influenced the estimated emissions; uncertainty (1σ) in emissions was 0.5 ± 0.3 µg m−2 s−1 if the field of interest received a clean measured upwind background air, but increased to 1.1 ± 0.5 µg m−2 s−1 if all upwind sources were advecting N2O over the field of interest. Moreover, higher short-period emission rates (e.g., half-hour) were observed in this study by a factor of 1.5~7 than other micrometeorological studies measuring N2O-N loss from the N-fertilized cereal cropping system. This increment was attributed to the increase in N fertilizer input and soil temperature during the measurement. We concluded that this method could make near-continuous “simultaneous” flux comparisons between treatments, but further studies are needed to address the discrepancies in the presented values with other comparable N2O flux studies.
Evaluating and clustering retrosynthesis pathways with learned strategy

With recent advances in the computer-aided synthesis planning (CASP) powered by data science and machine learning, modern CASP programs can rapidly identify thousands of potential pathways for a given target molecule. However, the lack of a holistic pathway evaluation mechanism makes it challenging to systematically prioritize strategic pathways except for using some simple heuristics. Herein, we introduce a data-driven approach to evaluate the relative strategic levels of retrosynthesis pathways using a dynamic tree-structured long short-term memory (tree-LSTM) model. We first curated a retrosynthesis pathway database, containing 238k patent-extracted pathways along with ∼55 M artificial pathways generated from an open-source CASP program, ASKCOS. The tree-LSTM model was trained to differentiate patent-extracted and artificial pathways with the same target molecule in order to learn the strategic relationship among single-step reactions within the patent-extracted pathways. The model achieved a top-1 ranking accuracy of 79.1% to recognize patent-extracted pathways. In addition, the trained tree-LSTM model learned to encode pathway-level information into a representative latent vector, which can facilitate clustering similar pathways to help illustrate strategically diverse pathways generated from CASP programs.
Trace elements in sediments and bioaccumulation in European silver eels (Anguilla anguilla L.) from a Mediterranean lagoon (SE Italy)

Samples of surface sediments and tissues (liver and muscle) of commercially available European silver eels (Anguilla anguilla L.) collected from Varano lagoon (Italy) were analysed to determine trace element contents. Univariate and multivariate analyses were performed to highlight both the differences between sampling sites and the influence of channel discharges. Atomic ratios indices for sediment data and biological enrichment factors (BEF) for eel tissues were calculated in order to evaluate the enrichment factor due to human activities. The highest levels of As (11.9 µg g−1) and Zn (14.1 µg g−1) were observed in the south-eastern zone of the lagoon, which is influenced by urban and agricultural discharges. The low levels of Hg observed in this study (0.04 µg g−1) led us to exclude both natural and human local sources of this element. Trace element concentrations of all elements were lower in muscle than in liver tissue. Significant enrichment of Cu and Zn was found in livers.
The Effect of Solution-Focused Brief Approach on Adolescent Subjective Well-Being: An Experimental Study

The aim of this study is to examine the effect of solution-focused brief approach based on subjective well-being improvement program on adolescents' subjective well-being levels. The study group consisted of 36 adolescents with low subjective well-being pre-test scores. The research is a study based on true experimental design with pre-test which has experimental-control-placebo group, post-test and follow-up test measurements. In this study, Adolescent Subjective Well-Being Scale and Personal Information Form were used as data collection tools. Kruskal Wallis H Test for Independent Samples, Mann Whitney U Test for Independent Samples and Wilcoxon Signed Rank Test for Paired Samples were used to analyze data. According to obtained results, it was determined that there was a significant increase in subjective well-being post-test scores of adolescents in the experimental group compared to the pre-test scores, control and placebo groups. It was observed that the increase in the post-test scores of the adolescents in the experimental group was preserved in the follow-up measurements. In the control and placebo groups, no significant difference was found between the pre-test, post-test, and follow-up test scores. According to the results of Wilcoxon Signed Rank Test for Paired Samples of the post-test scores and follow-up test scores of the groups; there was no significant difference between the post-test scores and follow-up test scores of the experimental group ( z = -.788, p >.05), control group ( z = -.520, p >.05) and placebo group ( z = -.570, p >.05). These findings show that the increase in subjective well-being scores of
Human Nonalcoholic Steatohepatitis on a Chip

Nonalcoholic steatohepatitis (NASH), an advanced stage of nonalcoholic fatty liver disease (NAFLD), is a rapidly growing and global health problem compounded by the current absence of specific treatments. A major limiting factor in the development of new NASH therapies is the absence of models that capture the unique cellular structure of the liver microenvironment and recapitulate the complexities of NAFLD progression to NASH. Organ‐on‐a‐chip platforms have emerged as a powerful approach to dynamically model diseases and test drugs. Herein, we describe a NASH‐on‐a‐chip platform. Four main types of human primary liver cells (hepatocytes [HCs], Kupffer cells, liver sinusoidal endothelial cells, and hepatic stellate cells [HSCs]) were cocultured under microfluidic dynamics. Our chip‐based model successfully recapitulated a functional liver cellular microenvironment with stable albumin and urea secretion for at least 2 weeks. Exposing liver chips to a lipotoxic environment led to gradual development of NASH phenotypic characteristics, including intracellular lipid accumulation, hepatocellular ballooning, HSC activation, and elevation of inflammatory and profibrotic markers. Further, exposure of the chip to elafibranor, a drug under study for the therapy of NASH, inhibited the development of NASH‐specific hallmarks, causing an ~8‐fold decrease in intracellular lipids, a 3‐fold reduction in number of ballooned HCs, a significant reduction in HSC activation, and a significant decrease in the levels of inflammatory and profibrotic markers compared with controls. Conclusion: We have successfully developed a microfluidic NASH‐on‐a‐chip platform that recapitulates the main NASH histologic endpoints in a single chip and that can emerge as a powerful noninvasive, human‐relevant, in vitro platform to study disease pathogenesis and develop novel anti‐NASH drugs.
Genomes Vary in Size and Spatial Patterns Within Chimeric Blades of Porphyra spp.

Genome size variation is of crucial biological importance, however variation in genome sizes within a single individual/organism is rarely reported except for some species groups such as algae where polygenomy, endopolyploidy and mixopolyploidy have previously been reported. The red algal genus Porphyra forms part of very profitable marine food products commonly known as ‘Nori’. Farming of these valuable marine crops was revolutionized by the discovery of their life cycle in the 40’s. One of the most remarkable characteristics of these taxa is the formation of chimeric gametophytic thalli. After meiosis, the four meiotic products are not released as individuals spores, but instead develop together into a single leafy thallus through successive mitotic divisions. In this study, we used flow cytometry to estimate genome sizes in 670 vegetative thallus sections from 195 blades from three Porphyra species, to determine if this chimerism could be related to the presence of multiple genome sizes and mixoploidy within thalli. Our results show a wide variety of genome sizes both within and between thalli. We interpreted these results as the presence of two different genome types of different sizes (a and b) with separate rounds of genome duplications within the vegetative thalli. By analyzing several sections per thallus, we were able to show that the different genome types and ploidy levels are not distributed haphazardly through the thallus, but are distributed along the thallus in a sectorial way in mosaics. In some individuals, the 2C genome size can either be interpreted as diploids or alternatively as haploid cells that are arrested at the G2-stage of the mitotic cycle, acting as diploid with two copies of their genome during most of their life-time. We conclude that Porphyra species belong to an aneuploid/euploid system, where genome duplications, mixoploidy, chromosomal dynamics and the presence of different genome types in the chimeric thalli play a role in shaping the genetic diversity of these taxa. Our results may have important implications to understand red algae biology and evolution and raise further questions on concepts of what constitutes an individual.