Miracle-dz/UniFAR-FTUs huggingface dataset:
Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders

Recent large-scale sequencing studies have identified a great number of genes whose disruptions cause neurodevelopmental disorders (NDDs). However, cell-type-specific functions of NDD genes and their contributions to NDD pathology are unclear. Here, we integrated NDD genetics with single-cell RNA sequencing data to identify cell-type and temporal convergence of genes involved in different NDDs. By assessing the co-expression enrichment pattern of various NDD gene sets, we identified mid-fetal cortical neural progenitor cell development—more specifically, ventricular radial glia-to-intermediate progenitor cell transition at gestational week 10—as a key convergent point in autism spectrum disorder (ASD) and epilepsy. Integrated gene ontology-based analyses further revealed that ASD genes function as upstream regulators to activate neural differentiation and inhibit cell cycle during the transition, whereas epilepsy genes function as downstream effectors in the same processes, offering a potential explanation for the high comorbidity rate of the two disorders. Together, our study provides a framework for investigating the cell-type-specific pathophysiology of NDDs.
Isolation and characterization of psychrotrophic proteolytic bacteria from landfill site under temperate climatic conditions of Kashmir Himalaya

The temperate climatic regions face the problem of waste accumulation due to lower environmental temperatures. However, these regions harbor cold active microbes viz. psychrotrophic proteolytic bacteria that play an important role in the degradation of protenaceous materials of the waste stream. Hence in the present study psychrotrophic proteolytic bacteria were isolated from waste samples collected from landfill site by using random sampling method under environmental temperature of 10oC. By using serial dilution and spread plate technique a total of 8 morphologically different psychrotrophic proteolytic bacteria were isolated on skim milk agar media at pH of 7.0 and temperature of 10°C after 48hours. Under in-vitro conditions all the isolates produced significant quantities of protease over the control and diameters of hydrolysis zones ranged between 2 to 18 mm at temperature range of 5 to 20oC and after 72 hours. The corresponding quantitative protease activities of the isolates was significant that ranged between 0.5 to 2.25 U/ml and the isolate PB2 was most efficient with highest protease activity of 2.25U/ml at 20oC. Based on 16SrRNA analysis the isolate was identified as Pseudomonas florescence with 96% similarity. It was concluded that the isolates can grow in wide ranges of temperature and could be used for enhanced decomposition of organic wastes during lower temperature conditions in cold regions. Further the isolates could have industrial applications due to the production of cold active proteases that would help economic benefits through energy conservation.
Privacy calculus or heuristic cues? The dual process of privacy decision making on Chinese social media

Purpose The purpose of this paper is to explore the antecedents of self-disclosure intention on mobile social applications. This study integrates privacy calculus model and elaboration likelihood theory to reconcile the rational and heuristic views of privacy decision making. Design/methodology/approach Using a “random dialing” sampling method, an empirical survey with 913 respondents was conducted. A series of regression models were employed to test the proposed relationships. Robust checks with sub-group analysis were conducted. Findings Self-disclosure intention develops along a dual route including the central route and the peripheral route. When the central route predominates, social media users form their attitudes toward self-disclosure based on a rational calculus of the privacy concern and perceived rewards. When the peripheral route predominates, users perform a more heuristic evaluation of relevant informational cues (information about privacy harms, the extent of information asymmetry between users and operators) and contextual cues (flow experience, privacy disclosure of friends). Peripheral cues moderate the relationships between central cues and self-disclosure intention. Originality/value This paper extends the Elaboration Likelihood Model by investigating the interaction between the central route and peripheral route. The results provide alternative explanations on the renowned “privacy paradox” phenomenon.
Challenges and opportunities with aquaculture growth

This special issue of Aquaculture Economics and Management features five articles based on contributions to the International Association of Aquaculture Economics and Management (IAAEM) sponsored section on economics and marketing at the Aquaculture America conference in New Orleans, Louisiana, March 7–11, 2019. The IAAEM sessions had 47 presentations spanning two full days. The range of topics was wide, but a major theme this year was the challenges and opportunities of continued growth in aquaculture, including growth in international trade and associated global seafood competition, as well as challenges with disease and environmental externalities of production growth. Aquaculture production is expected to continue to grow, and the presentations this year highlighted some of the several challenges and opportunities this brings. Expanding international trade and competition with domestic seafood sectors is a natural consequence of aquaculture production being primarily a developing nation activity, while developed nations such as the U.S. and European countries are primary importing and consumption regions (Anderson, Asche, & Garlock, 2018; Shamshak, Anderson, Asche, Garlock and Love, 2019). However, growing demand and limited fisheries capacity to supply seafood provide incentives for aquaculture production also in developed countries (Asche & Smith, 2018; Anderson, Asche, & Garlock, 2019; Kumar, Engle, & Tucker, 2018). Unfortunately, domestic wild fish interests, environmental NGOs, and other stakeholders often resist such developments (Knapp & Rubino, 2016). The first paper in this issue, Garlock, Nguyen, Anderson, and Musumba (2020) investigates the market potential of new farmed finfish species from the Gulf of Mexico. They find that it is more likely that domestic Gulf farmed fish will substitute for imports than for domestic wild-caught fish. Evidence suggests U.S. wholesale buyers value domestic fish over imported fish more than its specific production source. This is also related to a recent trend where the origin is more important than production technology (Kecinski, Messer, Knapp, & Shirazi, 2017).
Services trade and credit frictions: Evidence with matched bank–firm data

This paper investigates the relationship between bank credit and exports of services by Italian firms. In order to identify the role of credit supply in services exports we use matched data on bank-firm relationships and the shocks affecting banks’ funding during the sovereign debt crisis. The study suggests that credit supply shocks had a significant impact on services exports: a bank credit reduction of 1% led to a fall in exports of about 0.40%. These results hold even after controlling for alternative sources of firms’ external finance, unobserved credit demand heterogeneity and a number of robustness checks.
Real-variable characterizations of Musielak–Orlicz Hardy spaces on spaces of homogeneous type

Let (X , d, μ) be a space of homogeneous type in the sense of Coifman and Weiss. In this article, the authors establish a complete real-variable theory of Musielak–Orlicz Hardy spaces on (X , d, μ). To be precise, the authors first introduce the atomic Musielak–Orlicz Hardy space H at (X ) and then establish its various maximal function characterizations. The authors also investigate the Littlewood–Paley characterizations of H at (X ) via Lusin area functions, Littlewood– Paley g-functions and Littlewood–Paley g∗ λ-functions. The authors further obtain the finite atomic characterization of H at (X ) and its improved version in case q < ∞, and their applications to criteria of the boundedness of sublinear operators from H at (X ) to a quasi-Banach space, which are also applied to the boundedness of Calderón–Zygmund operators. Moreover, the authors find the dual space of H at (X ), namely, the Musielak–Orlicz BMO space BMO(X ), present its several equivalent characterizations, and apply it to establish a new characterization of the set of pointwise multipliers for the space BMO(X ). The main novelty of this article is that, throughout the article, except the last section, μ is not assumed to satisfy the reverse doubling condition.
Width variations control the development of grain structuring in steep step‐pool dominated streams: insight from flume experiments

We report results from flume experiments designed to study the effect of width variations on the formation and stability of steps in steep streams. To physically model channel width changes we inserted multiple trapezoidal elements in the flume. Two competing effects are in play: a fluidic effect, suggesting that steps are more likely to form in wide areas because of deposition enhanced by lower shear stress, and a granular effect, suggesting that steps are more likely to form in narrow areas because of particle jamming. Our experiments show that width variations enhance the formation of steps. Although steps can form in every location, those in narrow/narrowing areas are more common, more stable and they occupy a larger portion of the channel width. These results stress the importance of particle interactions in coarse‐bedded streams and help river engineers by providing a new element to consider when designing step‐pool sequences in river restoration projects. © 2020 John Wiley & Sons, Ltd.
The Prevalence of Intestinal Metaplasia in Dyspeptic Patients

Abstract Gastric cancer may be asymptomatic until advanced stages so it is important to detect the precancerous lesions. One of these precancerous lesions is Intestinal Metaplasia (IM). This study aimed to find out the prevalence of IM and its related risk factors in dyspeptic patients. In this cross-sectional study, 1650 dyspeptic patients above 15 years who were undergoing endoscopy department in two hospitals in Khorramabad, Iran, were invited to participate in the study during October 2015 to August 2016. The patients were examined in terms of erythema and inflammation, ulcers, erosions, atrophy, mass, gastric outlet obstruction during upper endoscopy. Six biopsy samples were taken and fixed in 10 percent formalin solution and then were sent to the pathology laboratory for histological examination. Data were analyzed by SPSS 21. In total, 1016 patients were entered in this study. The overall prevalence of IM was 10.5% (107/1016). In dyspeptic patients; the prevalence of complete and incomplete IM was 12.15% and 87.85% respectively. Increasing age, smoking and peptic ulcer were significantly related to IM (P<0.001, P=0.027, P=0.012). There was no significant meaning between gender, level of education, place of residence, family history of gastric cancer, opium, hookah smoking and alcohol consumption with IM. The relatively high prevalence of IM was found in dyspeptic patients. Especially incomplete subtype is a risk factor of gastric cancer and due to its relationship with smoking and increasing age, it is recommended to provide preventive procedures of gastric cancer in elderly aged and smokers. Keywords Author Keywords:Dyspepsia; Prevalence; Risk Factor; Intestinal Metaplasia
Study regarding the oral health in children from the Constanta city School for the disabled

The aim of this paper is to investigate children of the Constanta School for the disabled and to ascertain the diseases encountered as well as the possible correlation with their handicap, along with the possibility of implementing certain oral health programs, carried out by the help of Dental Medicine students during the preventive and community dentistry clinical practices. 259 children aged 6 to 18 years old are registered in Constanta School for the disabled. Our study comprised a batch of children from grades I-IV, who are also subjected to oral rinses with fluoridated solution. 87 boys and girls aged 7-14 years old were examined according to a special clinical record. Our results show that the first place is taken by children with medium mental disability (50%), the second by children with slight mental disability (29%) and the last by those with severe mental disability (21%). Our data are similar to those in the literature, in which dental caries take the first place regarding the frequency. Thus, simple and complicated decay in temporary teeth is 40%, while in permanent teeth, it rises to 45%. Taking into account the specificity of the study batch and comparing our clinical data with those of other authors, made on normal children, we can state that the percentage of all diseases is much higher in disabled children, fact that triggers the need of applying oral prevention programs and individualized curative treatment methods in these patients.
Psychiatric Morbidity Associated with Hip Fractures - A Hospital Based Study

Background: Most prevalent type of fractures encountered in elderly population are fall related hip fractures, which are even more common in female elderly population. Studies have shown such type of fractures are associated with psychiatric morbidity. This study is being taken into account for evaluation of different type of psychiatric morbidities associated with hip fractures in elderly population. Methods: This retrospective study is conducted Teerthankar Mahaveer medical college hospital, Moradabad, on 45 patients, who underwent hip surgery in last six months. Results: Maximum number of patients with hip fracture were in the age range of (81-90 yrs), more so over in that category females with hip fractures were 80.95%, and least number of patients with hip fractures were in the age range of (61-70 yrs.). Conclusion: Delirium, dementia and depression are most severe type of neuro-psychiatric co-morbidities are associated with elderly hip fractures. These co-morbidities may be minimized by pre-operative and post-operative care.
On the path of time: temporal motion in typological perspective

ABSTRACT The Moving Ego and Moving Time metaphors have provided a fertile testing ground for the psychological reality of space–time metaphors. Despite this, little research has targeted the linguistic patterns used in these two mappings. To fill that gap, the current study uses corpus data to examine the use of motion verbs in two typologically different languages, English and Spanish. We first investigated the relative frequency of the two metaphors. Whereas we observed no difference in frequency in the Spanish data, our findings indicated that in English, Moving Time expressions are more prevalent than are Moving Ego expressions. Second, we focused on the patterns of use of the verbs themselves, asking whether well-known typological patterns in the expression of spatial motion would carry over to temporal motion. Specifically, we examined the frequencies of temporal uses of path and manner verbs in English and in Spanish. Contra the patterns observed in space, we observed a preference for path verbs in both languages, with this preference more strongly evident in English than in Spanish. In addition, our findings revealed greater use of motion verbs in temporal expressions in Spanish compared to English. These findings begin to outline constraints on the aspects of spatial conceptualization that are likely to be reused in the conceptualization of time.
Socioeconomic, Environmental, and Behavioral Determinants of Leprosy in Kediri, East Java

Background: Leprosy remains a major public health problem in the world, particularly in developing countries. Leprosy can be so progressive that damages skin, nerve, extremity, and eye organs of the affected patients. Cumulative incidence of leprosy amounted to 200,000 cases worldwide, with the highest incidences occuring in India, Brazil, and Indonesia. This study sought to examine the social economic, environmental, and behavioral determinants of leprosy in Kediri, East Java, using path analysis approach.Subjects and Method: This was an analytic observational study with case control design. The study was conducted at Leprosy Hospital, Kediri, East Java, from November to December 2017. A total sample of 150 study subjects consisting of 75 leprosy patients and 75 non-diseased subjects were selected for this study by fixed disease sampling. The dependent variable was leprosy. The independent variables were personal hygiene, education, employment status, family income, dwelling density, humidity, and migration. Data on leprosy diagnosis was taken from medical record. The other data were collected by questionnaire. The data were analyzed by path analysis.Results: The risk of leprosy increased with poorer personal hygiene (b= -1.20; 95% CI= -1.92 to -0.49; p=0.001), higher humidity (b= 0.73; 95% CI= 0.33 to 1.43; p=0.040), and migration (b= 0.94; 95% CI= 0.14 to 1.74; p= 0.022). Being employed status increased family income (b= 1.41; 95% CI= 0.72 to 2.11; p< 0.001). Low family income increased the likelihood of migration (b= -14; 95% CI= -1.71 to -3.19; p= 0.007) and dwelling density (b= -1.02; 95% CI= -1.71 to -0.32; p=0.004). Higher education level increased the likelihood of being employed (b= 1.41; 95% CI= 0.72 to 2.11; p< 0.001) and better personal hygiene (b= 1.15; 95% CI= 0.44 to 1.85; p= 0.001). Dwelling density increased the likelihood of humidity (b= 4.29; 95% CI= 3.22 to 5.37; p< 0.001). Conclusion: Migration, higher humidity, and poorer personal hygiene directly increase the risk of leprosy. Education, employment status, family income, and dwelling density indirectly affect the risk of leprosy. Keywords: Leprosy, social economic, environmental, personal hygieneCorrespondence: Anindita Hasniati Rahmah. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: aninditarahma22@gmail.com. Journal of Epidemiology and Public Health (2018), 3(2): 253-262https://doi.org/10.26911/jepublichealth.2018. 03.02. 05
CASCADE: A phase 3, randomized, double-blind study of vadastuximab talirine (33A) versus placebo in combination with azacitidine or decitabine in the treatment of older patients with newly diagnosed acute myeloid leukemia (AML).

TPS7066Background: AML is associated with poor survival rates in patients (pts) who are not eligible for intensive chemotherapy or allogeneic stem cell transplant (allo-SCT) due to advanced age, comorbidities, and/or disease risk factors. Non-intensive therapies, such as the hypomethylating agents (HMAs) azacitidine and decitabine, are frequently employed in this setting; however, response rates and survival remain suboptimal in this pt population. Vadastuximab talirine (33A) is a CD33-directed antibody conjugated to pyrrolobenzodiazepine (PBD) dimers. Upon binding, 33A is internalized and transported to the lysosomes where PBD is released via proteolytic cleavage of the linker, leading to DNA crosslinking and cell death. In preclinical studies, HMA priming followed by 33A exposure upregulated CD33 expression, increased DNA incorporation of the PBD dimer, and enhanced cytotoxicity. In a phase 1 study, 33A plus HMA was generally well tolerated without a significant pattern of off-target toxicity. Activity .
The impact of volume overload on technique failure in incident peritoneal dialysis patients

Abstract Background Technique failure in peritoneal dialysis (PD) can be due to patient- and procedure-related factors. With this analysis, we investigated the association of volume overload at the start and during the early phase of PD and technique failure. Methods In this observational, international cohort study with longitudinal follow-up of incident PD patients, technique failure was defined as either transfer to haemodialysis or death, and transplantation was considered as a competing risk. We explored parameters at baseline or within the first 6 months and the association with technique failure between 6 and 18 months, using a competing risk model. Results Out of 1092 patients of the complete cohort, 719 met specific inclusion and exclusion criteria for this analysis. Being volume overloaded, either at baseline or Month 6, or at both time points, was associated with an increased risk of technique failure compared with the patient group that was euvolaemic at both time points. Undergoing treatment at a centre with a high proportion of PD patients was associated with a lower risk of technique failure. Conclusions Volume overload at start of PD and/or at 6 months was associated with a higher risk of technique failure in the subsequent year. The risk was modified by centre characteristics, which varied among regions.
Setbacks in Self-Control: Failing Not Mere Resisting Impairs Subsequent Self-Control

Research on ego depletion has often relied on the dual-task setting employing short tasks with low ecological validity. The comparatively few studies on ego depletion in daily life so far used diverging operationalization and yielded ambiguous results. We argue that fundamental research on short-term self-control limitations can benefit from research on the limit violation effect, which highlights the danger to self-control when setbacks are attributed to internal causes. To test the role of setbacks and compare different ego depletion operationalizations in daily life, we used data from two ambulatory assessment studies (N = 125 and 205). No consistent ego depletion effects were observed in Study 1; instead, momentary self-control success was only impaired after setbacks (prior self-control efforts failed). The role of prior setbacks was replicated in Study 2, highlighting the importance of setbacks in subsequent self-control efforts beyond mere resisting, which should be incorporated in interventions targeting self-control improvements.
Browsing for Cunzaigan on WeChat: Young People’s Social Media Presence in Accelerated Urban China

This article examines how young Chinese adults living in urban areas experience cunzaigan (a Chinese word that translates to ‘sense of existence’) through sharing mundane life moments on the social media platform—WeChat. We draw on the theories of social acceleration and social presence to interpret this practice and, in so doing, find that for our participants, cunzaigan signifies a subjective experience, testifying that they are here, providing a counterpoint to their mobile and fast-paced urban lives. Drawing on their experience of temporal social presence on WeChat, we contend that technological developments, which have been identified as a key motor of social acceleration, can also be harnessed as a resource to serve ontological and social purposes in an accelerated social context. In so doing, we address the role that everyday engagements with social media play in shaping the temporal nature of young people’s lives.