Miracle-dz/UniFAR-FTUs huggingface dataset:
Delft University of Technology Ten-year outcomes of a randomised trial of laparoscopic versus open surgery for colon cancer

Background Laparoscopic surgery for colon cancer is associated with improved recovery and similar cancer outcomes at 3 and 5 years in comparison with open surgery. However, long-term survival rates have rarely been reported. Here, we present survival and recurrence rates of the Dutch patients included in the COlon cancer Laparoscopic or Open Resection (COLOR) trial at 10-year followup. Methods Between March 1997 and March 2003, patients with non-metastatic colon cancer were recruited by 29 hospitals in eight countries and randomised to either laparoscopic or open surgery. Main inclusion criterion for the COLOR trial was solitary adenocarcinoma of the left or right colon. The primary outcome was disease-free survival at 3 years, and secondary outcomes included overall survival and recurrence. The 10-year follow-up data of all Dutch patients were collected. Analysis was by intentionto-treat. The trial was registered at ClinicalTrials.gov (NCT00387842). Results In total, 1248 patients were randomised, of which 329 were Dutch. Fifty-eight Dutch patients were excluded and 15 were lost to follow-up, leaving 256 patients for 10-year analysis. Median follow-up was 112 months. Disease-free survival rates were 45.2 % in the laparoscopic group and 43.2 % in the open group (difference 2.0 %; 95 % confidence interval (CI) -10.3 to 14.3; p = 0.96). Overall survival rates were 48.4 and 46.7 %, respectively (difference 1.7 %; 95 % CI -10.6 to 14.0; p = 0.83). Stage-specific analysis revealed similar survival rates for both groups. Sixty-two patients were diagnosed with recurrent disease, accounting for 29.4 % in the laparoscopic group and 28.2 % in the open group (difference 1.2 %; 95 % CI -11.1 to 13.5; p = 0.73). Seven patients had portor wound-site recurrences (laparoscopic n = 3
Cancellation, elliptic surfaces and the topology of certain four-manifolds.

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University of Birmingham Glyoxal yield from isoprene oxidation and relation to formaldehyde

Glyoxal (CHOCHO) is produced in the atmosphere by the oxidation of volatile organic compounds (VOCs). Like formaldehyde (HCHO), another VOC oxidation product, it is measurable from space by solar backscatter. Isoprene emitted by vegetation is the dominant source of CHOCHO and HCHO in most of the world. We use aircraft observations of CHOCHO and HCHO from the SENEX campaign over the southeast US in summer 2013 to better understand the CHOCHO time-dependent yield from isoprene oxidation, its dependence on nitrogen oxides (NOx ≡NO+NO2), the behavior of the CHOCHO–HCHO relationship, the quality of OMI CHOCHO satellite observations, and the implications for using CHOCHO observations from space as constraints on isoprene emissions. We simulate the SENEX and OMI observations with the Goddard Earth Observing System chemical transport model (GEOSChem) featuring a new chemical mechanism for CHOCHO formation from isoprene. The mechanism includes prompt CHOCHO formation under low-NOx conditions following the isomerization of the isoprene peroxy radical (ISOPO2). The SENEX observations provide support for this prompt CHOCHO formation pathway, and are generally consistent with the GEOS-Chem mechanism. Boundary layer CHOCHO and HCHO are strongly correlated in the observations and the model, with some departure under low-NOx conditions due to prompt CHOCHO formation. SENEX vertical profiles indicate a free-tropospheric CHOCHO background that is absent from the model. The OMI CHOCHO data provide some support for this free-tropospheric background and show southeast US enhancements consistent with the isoPublished by Copernicus Publications on behalf of the European Geosciences Union. 8726 C. Chan Miller et al.: Glyoxal yield from isoprene prene source but a factor of 2 too low. Part of this OMI bias is due to excessive surface reflectivities assumed in the retrieval. The OMI CHOCHO and HCHO seasonal data over the southeast US are tightly correlated and provide redundant proxies of isoprene emissions. Higher temporal resolution in future geostationary satellite observations may enable detection of the prompt CHOCHO production under low-NOx conditions apparent in the SENEX data.
Coffee, Depression, Alcoholism and Drug Abuse – A Mini-review

Coffee is a natural product that when roasted and brewed delivers thousands of pharmacologically active compounds. Recent studies have revealed that 3 to 4 cups of coffee a day as pleasurable, low cost and convenient way to prevent diverse health problems. Depression, a common mood disorder, is a risk factor for alcoholism and substance abuse. In the last decade, epidemiological studies illuminating preventative effects of coffee have shown an inverse relationship of consumption with the risk of developing diseases affecting the central nervous system. The caffeine in coffee is widely studied and often assumed to be the key pharmacologically active ingredient if not the singular active agent. However other pharmacologically active constituents, primarily chlorogenic acids and related quinides, are demonstrating health benefits. These abundant components are capable of promoting ‘in vivo’ inhibition of morphine- inducedanti-nociceptive behavior in mice in the same order of magnitude as that reported for naloxone. This review explores the interplay among coffee, depression, alcohol and drug consumption. It explores the preventative effects of coffee and proposes a mechanistic theory to explain the action of coffee constituents on mood disorders such as depression and their consequences as alcoholism and drug abuse.
U SAGE AMONG THE E LDERLY IN I RAN 伊朗老年人互聯網使用的新概念模型

The article describes a research study looking at internet usage among the elderly in Iran. The Internet offers several benefits for the elderly. However, internet usage among the Iranian elderly is at a low level. Moreover, very few studies have explored the reasons for this low usage making this study highly relevant and important. Their numbers in the total population are expected to form 20% in another three decades. This study aimed to survey the elderly users and non-users of the Internet to see what factors enable its uptake. One hundred twenty-seven elderly users and 51 non-users participated in a questionnaire survey designed using the Unified Theory of Acceptance and Use of Technology (UTAUT). Twenty users and non-users were also interviewed to gather richer details about the research topic. The findings show that performance and effort expectancy, social influence, facilitating conditions, and knowledge acquisition significantly predict the behavioral intention of the Iranian elderly to use the Internet. The findings are presented in a new conceptual model to help understand the motivations behind internet use. This study has implications for the research community and the technology industry in Iran and beyond as it indicates how the elderly can be attracted to adopt Internet technology.
Tadesse, Frew and Fogarty, Andrew W. and Deressa, Wakgari (2017) Prevalence and associated risk factors of malaria among adults in East Shewa Zone of Oromia Regional State, Ethiopia: a cross-sectional study. BMC

Background: Malaria is one of the most important causes of morbidity and mortality in sub-Saharan Africa. The disease is prevalent in over 75% of the country’s area making it the leading public health problems in the country. Information on the prevalence of malaria and its associated factors is vital to focus and improve malaria interventions. Methods: A cross-sectional study was carried out from October to November 2012 in East Shewa zone of Oromia Regional State, Ethiopia. Adults aged 16 or more years with suspected malaria attending five health centers were eligible for the study. Logistic regression models were used to examine the effect of each independent variable on risk of subsequent diagnosis of malaria. Results: Of 810 suspected adult malaria patients who participated in the study, 204 (25%) had microscopically confirmed malaria parasites. The dominant Plasmodium species were P. vivax (54%) and P. falciparum (45%), with mixed infection of both species in one patient. A positive microscopic result was significantly associated with being in the age group of 16 to 24 years [Adjusted Odds Ratio aOR 6.7; 95% CI: 2.3 to 19.5], 25 to 34 years [aOR 4.2; 95% CI: 1.4 to 12.4], and 35 to 44 years [aOR 3.7; 95% CI: 1.2–11.4] compared to 45 years or older; being treated at Meki health center [aOR 4.1; 95% CI: 2.4 to 7.1], being in Shashemene health center [aOR = 2.3; 95% CI: 1.5 to 4.5], and living in a rural area compared to an urban area [aOR 1.7; 95% CI: 1.1 to 2.6)]. Conclusion: Malaria is an important public health problem among adults in the study area with a predominance of P. vivax and P. falciparum infection. Thus, appropriate health interventions should be implemented to prevent and control the disease.
Fukushima fallout in Sakhalin Region , Russia , part 1 : 137 Cs and 134 Cs in grassland soils

The 2011 accident at the Fukushima-Daiichi nuclear power plant (FDNPP) resulted in the atmospheric releases of large quantities of man-made radionuclides [1, 2, 3]. In the mediumand long-term perspective, the Cs (T 1/2 = 30 y) and Cs (T 1/2 = 2.06 y) radionuclides were of the major radiological concern [4, 5, 6]. The most significant radioactive contamination occurred on Honshu Island in Japan in the immediate vicinity of the FDNPP, where the density of ground contamination by Cs reached the level of 3000 kBq m−2 and even higher [6]. More than 100000 citizens were evacuated or voluntary left the affected areas; various remediation actions were initiated at the heavily contaminated sites of Japan [1, 7, 8]. After the accident, Fukushima-derived Cs and Cs were also detected in the environmental media in many other countries in the Northern Hemisphere [2, 3]. Here, the Cs and Cs activity concentrations in environmental samples and food-staff, the ground deposition densities of the radionuclides, and expected exposure of humans were significantly lower compared to the permissible levels (e.g., [5, 9]). Results of such studies were beneficial to reduce social anxiety in the early period after the accident [5, 10]. At the same time, the measurement data collected after the Fukushima accident beyond the territory of Japan could be used as an experimental background for verification and improvement of the large-scale models describing atmospheric dispersion and deposition of radionuclides over the globe and assessment of the environmental and human health risks [9, 11]. Additionally, the Fukushima accident triggered a new wave of radioecological studies which have refreshed and deepened the knowledge about current levels of DOI: 10.21514/1998-426Х-2018-11-1-25-42 УДК: 546.36:621.039. 586:614.876(571.64)
Genomic inbreeding and population structure of northern pike (<fi>Esox lucius</fi>) in Xinjiang, China

Northern pike (Esox lucius) is an aggressive carnivorous fish that lives at the top of the food chain, known as “aquatic wolf,” and widely distributed in the high latitudes of the northern hemisphere (mainly above latitude 40° to the Arctic zone) (Forsman et al., 2015). Northern pike is known for their apparently low genetic variability, compared to other freshwater fishes (Pedreschi et al., 2014; Senanan & Kapuscinski, 2000). It was suggested as a reason of low genetic diversity for northern pike that the refuge of pike was greatly compressed northward during the glacial period in geological history, causing population bottleneck (Wooller et al., 2015). In the postglacial period, the fish population and distribution area expanded again, which resulted in a mismatch between genetic diversity and distribution area. Interestingly, northern pike has a strong ability to spread and colonize in changing environments, which is not Received: 13 October 2020 | Revised: 28 February 2021 | Accepted: 3 March 2021 DOI: 10.1002/ece3.7469
A Novel Cytoplasmic Membrane Protein in TNF-α Stimulated Cholangiocarcinoma Cells

Cholangiocarcinoma (CCA) is a malignant tumor of the biliary tract that has a high incidence in Southeast Asia, including Thailand (Srivatanakul et al., 2004; Sripa and Pairojkul, 2008). Liver fluke (Opithorchis viverrini) infection, together with nitrosamine consumption are the main risk factors associated with cancer development (Chainuvati et al., 1976; Haswell-Elkins et al., 1992; Prayong et al., 2014; Yothaisong et al., 2014). Numerous studies have attempted to explain the mechanisms of CCA and to discover its biomarkers. CYP39A1, RUNX2 and Oxidized Alpha-1 Antitrypsin have been associated with Cholangiocarcinoma progression (Khenjanta et al., 2014). The ratio of cathepsin B to cystatin C in patient serum was investigated as a marker for CCA diagnosis (Monsouvanh et al., 2014). FXYD3, GPRC5A, CEACAM5, MUC13, EPCAM, TMC5, and EHF were upregulated in intrahepatic CCA using microarray analysis which led to the molecular basic mechanisms of CCA (Subrungruanga et al., 2013). Cytoplasmic membrane
STRONG CONVERGENCE RATES FOR EULER APPROXIMATIONS

We consider a class of stochastic path-dependent volatility models where the stochas5 tic volatility, whose square follows the Cox–Ingersoll–Ross model, is multiplied by a (leverage) func6 tion of the spot process, its running maximum, and time. We propose a Monte Carlo simulation 7 scheme which combines a log-Euler scheme for the spot process with the full truncation Euler scheme 8 or the backward Euler–Maruyama scheme for the squared stochastic volatility component. Under 9 some mild regularity assumptions and a condition on the Feller ratio, we establish the strong conver10 gence with order 1/2 (up to a logarithmic factor) of the approximation process up to a critical time. 11 The model studied in this paper contains as special cases Heston-type stochastic-local volatility mod12 els, the state-of-the-art in derivative pricing, and a relatively new class of path-dependent volatility 13 models. The present paper is the first to prove the convergence of the popular Euler schemes with a 14 positive rate, which is moreover consistent with that for Lipschitz coefficients and hence optimal. 15
AHEART November 46/5

Bundy, Ruth, Nándor Marczin, Adrian H. Chester, and Magdi Yacoub. Differential regulation of DNA synthesis by nitric oxide and hydroxyurea in vascular smooth muscle cells. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1799–H1807, 1999. —We investigated the influence of nitrovasodilators on DNA synthesis in cultured human aortic smooth muscle cells and explored the hypothesis that nitric oxide (NO) is directly involved in mediating the inhibitory effects of hydroxyurea on DNA synthesis. Both NO and hydroxyurea inhibited ongoing DNA synthesis and S phase progression in our cells. Exogenous deoxynucleosides partially reversed this inhibition, suggesting that ribonucleotide reductase is a primary target for both NO and hydroxyurea. Nitrovasodilators inhibited DNA synthesis by releasing NO, as detected by chemiluminescence and as shown by the reversal of DNA synthesis inhibition by NO scavengers. This inhibition appears to occur via a cGMP-independent mechanism. In contrast, hydroxyurea did not produce a detectable NO signal, and NO scavengers had no influence on its inhibition of DNA synthesis, suggesting that NO does not mediate the inhibitory action of hydroxyurea in our system. Furthermore, the action of nitrovasodilators and hydroxyurea on DNA synthesis differed according to redox sensitivity. The redox agents N-acetyl-L-cysteine and ascorbate reversed NO inhibition of DNA synthesis and had no effect on DNA synthesis inhibition caused by hydroxyurea.
‘Reply to “Clinical Safety and Efficacy of Secondary Prophylactic Pegylated G-CSF in Advanced Pancreatic Cancer Patients Treated with mFOLFIRINOX: A Single-center

The Authors Reply We thank Dr. Chen et al. for their interest in our article, in which we assessed the clinical efficacy and safety of modified FOLFIRINOX (mFOLFIRINOX) combined with secondary prophylaxis using Pegylated granulocyte colony-stimulating factor (Peg G) in advanced pancreatic cancer patients (1). They raised several concerns regarding our study. First, Dr. Chen et al. pointed out that the incidence of grade 3 or 4 anorexia and nausea was lower in our study than in a previous study in which pancreatic cancer patients were treated with FOLFIRINOX combined with primary prophylaxis using Peg G (2). Thus, the incidence of these non-hematological toxicities accompanied by mFOLFIRINOX and Peg G was comparable to that of mFOLFIRINOX combined with primary prophylaxis using Peg G studies (3-5) and mFOLFIRINOX-only studies (6, 7). These previous findings along with our own suggest that FOLFIRINOX combined with using Peg G might increase the incidence of anorexia and nausea compared with mFOLFIRINOX with or without Peg G. However, we must be cautious regarding the interpretation of the data obtained by our group and Terazawa et al. (2), since the numbers of patients enrolled in both studies are limited. Thus, the incidence of nausea and anorexia accompanied by mFOLFIRINOX combined with Peg G needs to be re-evaluated in future studies including a larger number of patients. Dr. Chen et al. raised another issue regarding the incidence of bone pain accompanied by multiple Peg G injections. As they pointed out, multiple G-CSF injections often induce bone pain. Unexpectedly, we did not experience the discontinuation of mFOLFIRINOX regimen due to musculoskeletal pain in this study despite multiple injections of Peg G. The lack of patients complaining of musculoskeletal pain might be attributed to the fact that the primary disease in our study was advanced pancreatic cancer, and many patients were being administered non-steroidal antiinflammatory drugs (NSAIDs) for cancer-related pain relief. Given that NSAIDs are effective in relieving both bone pain and cancer-related pain, it is likely that the administration of NSAIDs might have ameliorated bone pain. Finally, Dr. Chen et al. argue that it is too early to determine the cost-effectiveness of mFOLFIRINOX combined with Peg G. We agree with this opinion and feel that largescale, multi-center prospective trials will be required in order to determine the cost-effectiveness. Such future studies will be useful for assessing not only the cost-effectiveness but also the non-hematological toxicities of mFOLFIRINOX combined with Peg G.
SPIRITUAL CAPACITIES OF PERSONALITY AND PRODUCTIVE LIFE ACTIVITY

Interest in the study of the spiritual aspects of personality has increased in the scientific community. One of the important areas of such research is related to spiritual intelligence. Emmons (1999) determined spiritual intelligence as an adaptive use of spiritual guidance to help goal attainment and to solve problems of day-to-day life. Abstract The article deals with the psychological aspects of spirituality. The concepts of spiritual intelligence, spiritual capacities, and spiritual personality are analyzed. The study was based on the idea of a psychological model of spiritual capacities proposed by the author. This model includes three components: moral, mental, and transcendent. The moral component was selected to be explored in detail and was empirically studied. The principal constituent of the moral component of spiritual capacities is a spiritual altruistic tendency; its connection with productive life is analyzed in the article. The objective of the study was the investigation of the relationships between spiritual personality, spiritual capacities and productive life activity. The participants were 662 adults (206 males, 456 females): students and full-time employees aged 18–45 years (M = 26.08) from two cities of the Russian Federation (Kostroma and Taganrog). Correlational and comparative analysis was used for data processing. It was found that respondents with higher levels of “spiritual personality” significantly differed, according to the Mann–Whitney U test by a higher productivity of life activity (U = 43028; p < .001) and had higher levels of spiritual capacities — the spiritual altruistic tendency (U = 46328,5; p < .022). The correlational analysis showed that the higher was the level of manifestation of spiritual capacities — the spiritual altruistic tendency, the higher was the productivity of life activity. The results obtained make it possible to note the importance of the construct “spiritual capacities” and the need for its further scientific psychological research, as well as to emphasize the practical significance of spiritual capacities for the prosperous and productive functioning of society.
or Immobilized Ligands on Surfaces Membrane Dynamics upon Binding Mobile RI e Formation of a Mast Cell Synapse: Fc

Fc « RI on mast cells form a synapse when presented with mobile, bilayer-incorporated Ag. In this study, we show that receptor reorganization within the contacting mast cell membrane is markedly different upon binding of mobile and immobilized ligands. Rat basophilic leukemia mast cells primed with ﬂuorescent anti-DNP IgE were engaged by surfaces presenting either bilayer-incorporated, monovalent DNP-lipid (mobile ligand), or chemically cross-linked, multivalent DNP (immobilized ligand). Total internal reﬂection ﬂuorescence imaging and electron microscopy methods were used to visualize receptor reorganization at the contact site. The spatial relationshipsofFc « RItoothercellularcomponentsatthesynapse,suchasactin,cholesterol,andlinkerforactivationofTcells,werealso analyzed. Stimulation of mast cells with immobilized polyvalent ligand resulted in typical levels of degranulation. Remarkably, degranulation also followed interaction of mast cells, with bilayers presenting mobile, monovalent ligand. Receptors engaged with mobile ligand coalesce into large, cholesterol-rich clusters that occupy the central portion of the contacting membrane. These data indicate that Fc « RI cross-linking is not an obligatory step in triggering mast cell signaling and suggest that dense populations of mobile receptors are capable of initiating low-level degranulation upon ligand recognition. The Journal of Immunology , 2010, 184: 1328–1338.