Miracle-dz/UniFAR-FTUs huggingface dataset:
Meta-Analysis of Percutaneous Endomyocardial Cell Therapy in Patients with Ischemic Heart Failure by Combination of Individual Patient Data (IPD) of ACCRUE and Publication-Based Aggregate Data

Individual patient data (IPD)-based meta-analysis (ACCRUE, meta-analysis of cell-based cardiac studies, NCT01098591) revealed an insufficient effect of intracoronary cell-based therapy in acute myocardial infarction. Patients with ischemic heart failure (iHF) have been treated with reparative cells using percutaneous endocardial, surgical, transvenous or intracoronary cell delivery methods, with variable effects in small randomized or cohort studies. The objective of this meta-analysis was to investigate the safety and efficacy of percutaneous transendocardial cell therapy in patients with iHF. Two investigators extracted the data. Individual patient data (IPD) (n = 8 studies) and publication-based (n = 10 studies) aggregate data were combined for the meta-analysis, including patients (n = 1715) with chronic iHF. The data are reported in accordance with PRISMA guidelines. The primary safety and efficacy endpoints were all-cause mortality and changes in global ejection fraction. The secondary safety and efficacy endpoints were major adverse events, hospitalization and changes in end-diastolic and end-systolic volumes. Post hoc analyses were performed using the IPD of eight studies to find predictive factors for treatment safety and efficacy. Cell therapy was significantly (p < 0.001) in favor of survival, major adverse events and hospitalization during follow-up. A forest plot analysis showed that cell therapy presents a significant benefit of increasing ejection fraction with a mean change of 2.51% (95% CI: 0.48; 4.54) between groups and of significantly decreasing end-systolic volume. The analysis of IPD data showed an improvement in the NYHA and CCS classes. Cell therapy significantly decreased the end-systolic volume in male patients; in patients with diabetes mellitus, hypertension or hyperlipidemia; and in those with previous myocardial infarction and baseline ejection fraction ≤ 45%. The catheter-based transendocardial delivery of regenerative cells proved to be safe and effective for improving mortality and cardiac performance. The greatest benefit was observed in male patients with significant atherosclerotic co-morbidities.
Indecomposables live in all smaller lengths

Let Λ be a finite‐dimensional k‐algebra with k algebraically closed. Bongartz has recently shown that the existence of an indecomposable Λ‐module of length n > 1 implies that also indecomposable Λ‐modules of length n − 1 exist. Using a slight modification of his arguments, we strengthen the assertion as follows: If there is an indecomposable module of length n, then there is also an accessible one. Here, the accessible modules are defined inductively, as follows. First, the simple modules are accessible. Second, a module of length n ⩾ 2 is accessible provided it is indecomposable and that there is a submodule or a factor module of length n − 1 which is accessible.
Square-mean almost automorphic solutions for some stochastic differential equations

The concept of square-mean almost automorphy for stochastic processes is introduced. The existence and uniqueness of square-mean almost automorphic solutions to some linear and non-linear stochastic differential equations are established provided the coefficients satisfy some conditions. The asymptotic stability of the unique square-mean almost automorphic solution in the square-mean sense is discussed.
Theorems on twin primes-dual case

We prove dual theorems to theorems proved by author in \cite {5}. Beginning with Section 10, we introduce and study so-called "twin numbers of the second kind" and a postulate for them. We give two proofs of the infinity of these numbers and a sufficient condition for truth of the postulate; also we pose several other conjectures. Finally, we consider a conception of axiom of type "AiB".
L^2-Betti numbers of coamenable quantum groups

We prove that a compact quantum group is coamenable if and only if its corepresentation ring is amenable. We further propose a Foelner condition for compact quantum groups and prove it to be equivalent to coamenability. Using this Foelner condition, we prove that for a coamenable compact quantum group with tracial Haar state, the enveloping von Neumann algebra is dimension flat over the Hopf algebra of matrix coefficients. This generalizes a theorem of Lueck from the group case to the quantum group case, and provides examples of compact quantum groups with vanishing L^2-Betti numbers.
On the soliton dynamics under a slowly varying medium for generalized KdV equations

We consider the problem of the soliton propagation, in a slowly varying medium, for a generalized Korteweg - de Vries equations (gKdV). We study the effects of inhomogeneities on the dynamics of a standard soliton. We prove that slowly varying media induce on the soliton solution large dispersive effects at large time. Moreover, unlike gKdV equations, we prove that there is no pure-soliton solution in this regime.
PECAM-1 Is Down-Regulated in γδT Cells during Remission, but Up-Regulated in Relapse of Multiple Sclerosis

Introduction. PECAM-1 and NKRP1A are both involved in the vascular transmigration of T lymphocytes. Vascular transmigration is a crucial process in multiple sclerosis pathogenesis. Methods and aim. The current paper presents an analysis of PECAM-1 and NKRP1A expression on γδ T cells. Expression of PECAM-1 and NKRP1A on subsets of γδ T cells was performed with flow cytometry. Results. Based on the flow cytometry data, PECAM1 was slightly differentially modulated on γδ T cells—it was up-regulated during relapse, but down-regulated during remission. Moreover, a significant downregulation of CD3 expression was noted on γδ T cells from MS patients, most notably during relapse. Conclusions. This may be a sign of the overall activation of γδ T cells in the course of multiple sclerosis.
Understanding The Definition and Characteristics of Dyslexia

Reading skills are an important element for obtaining knowledge in academic learning. Previous research has demonstrated that dyslexia pupils have a major problem with reading skills. The biggest issue of dyslexic pupils includes language learning disorder. Dyslexia could be a long-lasting impedance, and numerous indications hold on into adulthood. Identification of dyslexia at a preliminary phase comes from the ability to notice dyslexia characteristics, for instance, poor handwriting, written expression difficulties, spelling difficulties, reading fluency, and difficulty associating sounds with letters. Nevertheless, the investigation has exhibited that teachers and parents are still unaware of dyslexia. The goal of this article is to explore dyslexia’s definitions and characteristics that are associated with it. Dyslexia comprises different definitions and characters. Each dyslexic pupil encounters indications that are distinctive from each other. Understanding the definition of dyslexia and the character of early dyslexia can assist teachers in planning fitting intercessions for dyslexic pupils. Conclusions: The implications of this work are that it can assist educators in identifying students who have dyslexia characteristics or symptoms.
The maximal p-norm multiplicativity conjecture is false

For all 1 < p < 2, we demonstrate the existence of quantum channels with non-multiplicative maximal p-norms. Equivalently, the minimum output Renyi entropy of order p of a quantum channel is not additive for all 1 < p < 2. The violations found are large. As p approaches 1, the minimum output Renyi entropy of order p for a product channel need not be significantly greater than the minimum output entropy of its individual factors. Since p=1 corresponds to the von Neumann entropy, these counterexamples demonstrate that if the additivity conjecture of quantum information theory is true, it cannot be proved as a consequence of maximal p-norm multiplicativity.
Discrepancies of non-$\Q$-Gorenstein varieties

We give an example of a non $\Q$-Gorenstein variety which is canonical but not klt, and whose canonical divisor has an irrational valuation. We also give an example of an irrational jumping number and we prove that there are no accumulation points for the jumping numbers of normal non-$\Q$-Gorenstein varieties with isolated singularities.
New progress in enumeration of mixed models.

A mixed model is said to be constrained if none of its fixed factors is nested within a random factor. Hess and Iyer have asked the question of enumerating non-isomorphic mixed models (with or without constraint), solving the problem for mixed models of size at most 5. In this article, using previous results about posets, we present a new algorithm, and obtain results for mixed models of size at most 10.
Hamiltonian and small action variables for periodic dNLS

We consider the defocussing NLS equation with small periodic initial condition. A new approach to study the Hamiltonian as a function of action variables is demonstrated. The problems for the NLS equation is reformulated as the problem of conformal mapping theory corresponding to quasimomentum of the Zakharov-Shabat operator. The main tool is the L\"owner type equation for the quasimomentum. In particular, we determine the asymptotics of the Hamiltonian for small action variables. Moreover, we determine the gradient of Hamiltonian with respect to action variables. This gives so called frequencies and determines how the angles variables depend on the time.
Critre pour l'intgralit des coefficients de Taylor des applications miroir

Rsum Nous donnons une condition ncessaire et suffisante pour que les coefficients de Taylor de sries de la forme q(z) z exp(G(z)/F(z)) soient entiers, o F(z) et G(z) log(z)F(z) sont des solutions particulires de certaines quations diffrentielles hypergomtriques gnralises. Ce critre est bas sur les proprits analytiques de l'application de Landau (classiquement associe aux suites de quotients de factorielles) et il gnralise les rsultats de KrattenthalerRivoal dans On the integrality of the Taylor coefficients of mirror maps, Duke Math. Journal. Pour dmontrer ce critre, nous gnralisons entre autres un thorme de Dwork concernant les congruences formelles entre sries formelles dans On p-adic differential equations IV: generalized hypergeometric functions as p-adic functions in one variable, Annales scientifiques de l'ENS.
Detection of Mycoplasma gallisepticum in broiler chickens by PCR

Background: Mycoplasma is a significant microorganism of poultry, which can cause respiratory infections and synovial inflammation, bringing about huge financial misfortunes to poultry workmanship worldwide. Aim: The goal of existing research was to determine the infection rate of Mycoplasma gallisepticum (MG) from chronic respiratory disease cases among broilers fields in Mosul/ Iraq using the polymerase chain reaction (PCR) technique. Methods: All 92 lungs samples were collected from broilers with classical respiratory signs in different regions of the Nineveh governorate for 3 months from February to April 2021. Results: PCR tests were performed using two couple primers, one for the qualitative amplification of 16S rRNA genes (285 base pairs) in Mycoplasma spp. and the second couple for the detection of M. gallisepticum (580 base pairs). Among the samples obtained from broilers, 87 (94.7%) were positive for Mycoplasma and 79 (85.9%) were positive for M. gallisepticum. Conclusion: Our results showed that MG infection in broiler chickens leads to serious clinical symptoms and severe lesions. The rate of Mycoplasma isolation in this study is high despite the short lifespan of broiler chickens.
A Random String with Reflection in a Convex Domain

We study the motion of a random string in a convex domain O in ℝ d , namely the solution of a vector-valued stochastic heat equation, confined in the closure of O and reflected at the boundary of O. We study the structure of the reflection measure by computing its Revuz measure in terms of an infinite-dimensional integration by parts formula. Our method exploits recent results on weak convergence of Markov processes with log-concave invariant measures.
CLASS DEGREE AND RELATIVE MAXIMAL ENTROPY

Given a factor code π from a shift of finite type X onto an irreducible sofic shift Y , and a fully supported ergodic measure ν on Y , we give an explicit upper bound on the number of ergodic measures on X which project to ν and have maximal entropy among all measures in the fiber π−1{ν}. This bound is invariant under conjugacy. We relate this to an important construction for finite-to-one symbolic factor maps.
Epimorphisms between 2‐bridge link groups: homotopically trivial simple loops on 2‐bridge spheres

We give a complete characterization of those essential simple loops on 2‐bridge spheres of 2‐bridge links which are null‐homotopic in the link complements. Using this result, we describe all upper‐meridian‐pair‐preserving epimorphisms between 2‐bridge link groups.
New Exponential Ratio Estimator in Ranked Set Sampling

In this study, we adapted the families of estimators from Ünal and Kadilar (2021) using the exponential function for the population mean in case of non-response for simple random sampling for the estimation of the mean of the population with the RSS (ranked set sampling) method. The equations for the MSE and the bias of the adapted estimators are obtained for RSS and it in theory shows that the proposed estimator is additional efficient than the present RSS mean estimators in the literature. In addition, we support these theoretical results with real COVID-19 real data and conjointly the simulation studies with different distributions and parameters. As a result of the study, it was observed that the efficiency of the proposed estimator was better than the other estimators.
Levofloxacin Use in Patients with Suspected Tuberculosis in a Community Hospital, Thailand: A Pilot Study

Background Levofloxacin is one of the broad-spectrum antibiotics that is indicated for the second-line treatment of tuberculosis (TB). However, using levofloxacin as an empirical therapy for patients without confirmation of TB could still be observed. This descriptive retrospective study, therefore, aimed to investigate the number of levofloxacin use in patients suspected TB in a community hospital in Thailand. Methods Patient medical charts of all patients who were admitted to a community hospital in Nakhon Si Thammarat, Thailand, from 2016 to 2017, were reviewed. Patients who were suspected TB and received any levofloxacin-containing regimens were included. Data on patient characteristics and the received regimens were descriptively analyzed and reported as percentage and frequency. Results There were a total of 21 patients who received levofloxacin in the hospital. Six of them (28.57%) had the diagnosis of hepatitis. The most prescribed regimen as empirical therapy was levofloxacin, ethambutol, and amikacin (66.67%). After the confirmation of TB using acid-fast bacilli (AFB) test, ten patients (47.62%) still received levofloxacin-containing regimens. Conclusion The results from this study indicated high usage of levofloxacin despite no evidence of drug-resistant TB or negative AFB results in a community hospital in Thailand. The results from this study will be further used for the investigation of the prevalence of antibiotic resistance and clinical outcomes of using second-line regimens for TB treatment.
On the classical geometry of embedded surfaces in terms of Poisson brackets

We consider surfaces embedded in a Riemannian manifold of arbitrary dimension and prove that many aspects of their differential geometry can be expressed in terms of a Poisson algebraic structure on the space of smooth functions of the surface. In particular, we find algebraic formulas for Weingarten's equations, the complex structure and the Gaussian curvature.
Automorphism towers and automorphism groups of fields without Choice

This paper can be viewed as a continuation of [KS09] that dealt with the automorphism tower problem without Choice. Here we deal with the inequation which connects the automorphism tower and the normalizer tower without Choice and introduce a new proof to a theorem of Fried and Koll\'ar that any group can be represented as an automorphism group of a field. The proof uses a simple construction: working more in graph theory, and less in algebra.
Loop quantum dynamics of the Schwarzschild interior

We examine the Schwarzschild interior of a black hole, incorporating quantum gravitational modifications due to loop quantum gravity. We consider an improved loop quantization using techniques that have proven successful in loop quantum cosmology. The central Schwarzschild singularity is resolved and the implications for the fate of an in-falling test particle in the interior region is discussed. The singularity is replaced by a Nariai type universe. We discuss the resulting conformal diagram, providing a clear geometrical interpretation of the quantum effects.
HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo

Mebendazole and other benzimidazole antihelmintics, such as albendazole, fenbendazole, or flubendazole, have been shown to possess antitumour activity, primarily due to their microtubule-disrupting activity. However, the extremely poor water-solubility of mebendazole and other benzimidazoles, resulting in very low bioavailability, is a serious drawback of this class of drugs. Thus, the investigation of their antitumour potential has been limited so far to administering repeated high doses given peroral (p.o.) or to using formulations, such as liposomes. Herein, we report a fully biocompatible, water-soluble, HPMA copolymer-based conjugate bearing mebendazole (P-MBZ; Mw 28–33 kDa) covalently attached through a biodegradable bond, enabling systemic administration. Such an approach not only dramatically improves mebendazole solubility but also significantly prolongs the half-life and ensures tumour accumulation via an enhanced permeation and retention (EPR) effect in vivo. This P-MBZ has remarkable cytostatic and cytotoxic activities in EL-4 T-cell lymphoma, LL2 lung carcinoma, and CT-26 colon carcinoma mouse cell lines in vitro, with corresponding IC50 values of 1.07, 1.51, and 0.814 µM, respectively. P-MBZ also demonstrated considerable antitumour activity in EL-4 tumour-bearing mice when administered intraperitoneal (i.p.), either as a single dose or using 3 intermittent doses. The combination of P-MBZ with immunotherapy based on complexes of IL-2 and anti-IL-2 mAb S4B6, potently stimulating activated and memory CD8+ T cells, as well as NK cells, further improved the therapeutic effect.
Maternal Glycemic Spectrum and Adverse Pregnancy and Perinatal Outcomes in a Multiracial US Cohort

Diabetes mellitus (pregestational (PDM) and gestational (GDM)) is associated with adverse pregnancy outcomes (APOs). However, studies exploring the association of APOs with maternal glycemia among women without PDM/GDM are limited. We utilized data from 4119 women (307—PDM; 582—GDM; 3230—non-PDM/GDM) in the Boston Birth Cohort (1998–2016). Women in the non-PDM/GDM group were subdivided by tertiles of 1 h, 50 g oral glucose load test at 24–32 weeks: T1: 50–95 mg/dL (n = 1166), T2: 96–116 mg/dL (n = 1151), T3: 117–201 mg/dL (n = 913). Using multivariable logistic regression, we examined the association of maternal glycemia with APOs—preterm birth (PTB) and hypertensive disorders of pregnancy (HDP)—and adverse perinatal outcomes—high birth weight (HBW), cesarean section (CS), and sub-analyses by race-ethnicity. Compared to women in T1, women in T2 and T3 had a higher prevalence of pre-existing hypertension (T1: 2.8% vs. T2: 5.2% vs. T3: 6.3%) and obesity (T1: 13.3% vs. T2: 18.1% vs. T3: 22.9%). Women in T2 and T3 had higher odds of HBW (adjusted odds ratio aOR T2: 1.47 [1.01–2.19] T3: 1.68 [1.13–2.50]) compared to women in T1. Additionally, women in T2, compared to T1, had higher odds of HDP (aOR 1.44 [1.10–1.88]). Among non-Hispanic Black (NHB) women, those in T2 and T3 had higher odds of HDP compared to T1 (aOR T2 1.67 [1.13–2.51]; T3: 1.68 [1.07–2.62]). GDM and PDM were associated with higher odds of HBW, CS, PTB, and HDP, compared to women in T1. In this predominantly NHB and Hispanic cohort, moderate maternal glycemia without PDM/GDM was associated with higher odds of HBW and HDP, even more strongly among NHB women. If confirmed, a review of current guidelines of glucose screening and risk stratification in pregnancy may be warranted.
An integrating factor matrix method to find first integrals

In this paper we develop an integrating factor matrix method to derive conditions for the existence of first integrals. We use this novel method to obtain first integrals, along with the conditions for their existence, for two- and three-dimensional Lotka–Volterra systems with constant terms. The results are compared to previous results obtained by other methods.
MODULI SPACES OF FRAMED PERVERSE INSTANTONS ON ℙ3

Abstract We study moduli spaces of framed perverse instantons on ℙ3. As an open subset, it contains the (set-theoretical) moduli space of framed instantons studied by I. Frenkel and M. Jardim in [9]. We also construct a few counter-examples to earlier conjectures and results concerning these moduli spaces.
Observer‐based distributed fault‐tolerant containment control for stochastic nonlinear multi‐agent systems with asymmetric hysteretic quantization

This article investigates the distributed containment control problem for high‐order stochastic nonstrict‐feedback nonlinear multi‐agent systems. To overcome the difficulty of unknown control input gain caused by the asymmetric hysteretic quantization and actuator fault, the properties of Nussbaum function are employed and an auxiliary virtual controller is designed, which does not need to estimate the bounds of the parameters of asymmetric hysteretic quantizer and efficiency factors. Moreover, the unknown terms are estimated by introducing the radial basis function neural networks. Based on the input‐driven filter, an adaptive containment control scheme is designed by using the Nussbaum function technique, the backstepping approach, and the dynamic surface control method. It is shown that the proposed control method can guarantee that all the signals are semi‐globally uniformly ultimately bounded, and the containment control performance can be achieved. Finally, some simulation results are presented to illustrate the effectiveness of the proposed approach.
Homotopy perturbation method for fractional-order Burgers-Poisson equation

In this paper, the fractional-order Burgers-Poisson equation is introduced by replacing the first-order time derivative by fractional derivative of order $\alpha$. Both exact and approximate explicit solutions are obtained by employing homotopy perturbation method. The numerical results reveal that the proposed method is very effective and simple for handling fractional-order differential equations.
The evo‐devo origins of the nasopharynx

The process by which upper respiratory tract structures have changed over deep evolutionary time is, in part, reflected in the process of embryologic development. The nasopharynx in particular is a centrally located space bounded by components of the respiratory portion of the nasal cavity, cranial base, soft palate, and Eustachian tube. The development of these components can be understood both in terms of embryologic structures such as the branchial arches and paraxial mesoderm and through fossil evidence dating as far back as the earliest agnathan fish of the Cambrian Period. Understanding both the evolution and development of these structures has been an immeasurable benefit to the otolaryngologist seeking to model disease etiology of both common and rare conditions. This discussion is a primer for those who may be unfamiliar with the central importance of the nasopharynx both in terms of our evolutionary history and early embryological development of vital cranial and upper respiratory tract structures.