Miracle-dz/UniFAR-FTUs huggingface dataset:
An open-label, phase II basket study of olaparib and durvalumab (MEDIOLA): Results in patients with relapsed gastric cancer.

140 Background: Olaparib is a PARP inhibitor that has shown activity in relapsed gastric cancer (GC) when combined with chemotherapy. MEDIOLA assesses the efficacy and safety of a chemo-free combination of olaparib and durvalumab, an anti-programmed cell death ligand-1 (PD-L1) agent in patients (pts) with solid tumors, including relapsed GC (NCT02734004). Methods: Eligible pts had GC that relapsed following platinum-containing therapy. Pts received olaparib 300 mg PO BID for a 4-wk run-in to allow for serial biopsies, followed by combination olaparib and durvalumab (1.5 g IV q 4 wks) until progressive disease (PD) as measured by RECIST 1.1. Tumor measurements were taken at baseline, 4 wks and q 8 wks thereafter. Primary endpoints were disease control rate (DCR) at 12 wks, safety, and tolerability. The secondary endpoints included DCR at 28 wks, objective response rate (ORR), duration of response (DoR), progression-free survival, and OS. Biomarker endpoints included PD-L1 expression and evaluation of tumor infiltrating lymphocytes. Bayesian predictive probability design was used for statistical analysis. Results: Forty pts were included in the safety and 39 in the efficacy analysis. Among 39 pts, median age was 57 yrs (range 28–77). Nineteen pts (48%) had a grade 3 AE; three pts (8%) a grade 4 AE. Most common AEs were anemia, lipase increase, fatigue, dysphagia, hyponatremia, and alkaline phosphatase increase. Ten pts (25%) had immune-mediated AEs, most commonly rash. The ORR was 10%; two pts had complete response; two had partial response. Median DoR was 11.1 months. DCR at 12 wks was 26%. Further efficacy and biomarker data will be presented. Conclusions: The combination of olaparib and durvalumab was tolerable, with no unexpected AEs. All responses occurred after the addition of durvalumab and were durable, suggesting synergistic treatment effect of the combination in some pts. Furthermore, several pts with early PD showed unexpectedly long survival. DCR at 12 wks was below the target (70%) due to a high rate of early PDs following the olaparib run-in. To address the early treatment failures, an upfront addition of more aggressive therapies to the combination should be explored. Clinical trial information: NCT02734004.
In situ simulation of cardiac arrest

In-hospital cardiac arrest is one of the most complicated events healthcare providers will manage in a hospital setting. Cardiac arrest also is a rare event compared to other clinical events managed on a routine basis, requiring deliberate preparation of staff to be able to have the knowledge, technical skills and teamwork necessary to manage such an event when it occurs. Simulation-based education has been demonstrated to be an effective method of educating healthcare providers. More recently, hospital systems have begun using in situ simulation for the training of healthcare providers and identifying latent safety threats. In situ simulation is defined as: “Taking place in the actual patient care setting/environment in an effort to achieve a high level of fidelity and realism; this training is particularly suitable for difficult work environments, due to space constraints or noise”.
Brain Activity in College Students with the Broad Autism Phenotype

i Acknowledgements ii List of Figures vi List of Tables vii Chapter I: Introduction 1 Chapter II: Literature Review 3 Autism 3 The Broad Autism Phenotype 4 The Broad Autism Phenotype Questionnaire (BAPQ) 7 The Impact of Social Skills Deficits on College Students with ASD 9 The College Social Experience for Individuals with ASD 10 The College Social Experience for Individuals with BAP 13 The ASD/BAP STEM Connection 14 Face Processing In ASD 14 Processing of Facial Emotions and BAP 17 Face Processing Biological Structures and Function 21 Fusiform Gyrus 22 Amygdala 24
Laboratory Tests Used in the Diagnostic and Research of Dengue Virus: Present and Future

Dengue is a significant public health problem. There are four dengue virus serotypes identified; however, its diagnosis is difficult due to the existence of many viruses, bac -teria, and parasites producing the same clinical presentation, being present in the same geographical area and even producing coinfections. Therefore, determining whether a person has, had, or is infected with dengue virus is of great importance. In order to do so, direct and indirect laboratory tests have been developed to identify the virus or part of its structure that generally detects the antibody response. These techniques are used for diagnosis, epidemiological studies, monitoring, assessment and production of vaccines and antivirals, etc. They range from the use of cell cultures, animal models, inoculation by insects, and serology tests to the use of detection molecular tests and quantification of genetic material that are described in this chapter herein, a brief explanation of this methodology, its strengths and weaknesses, and its application in the dengue research. molecular techniques, and others. tubes, 6–96 well culture plates, and oth ers are used in order to sustain the binding to cell cultures. A modified shell vial technique allows the recovery of a higher number of YFV, SLV, WNV, ILHV, GCV, OROV, MAYV and DENV isolations. This technique follows the same steps as a standard method, but after inoculating cells, the cultures are centrifuged to velocities between 1800 and 2200 rpm. This technique can also be used to isolate DENV coinfections. However, it seems not to have good results for VEE isolation [19–22].
Sediment deposition and net phosphorus retention in a hydraulically restored lowland river floodplain in Denmark: combining field and laboratory experiments

Restoration of river systems allowing the transformation of former drained and dry riparian areas into riparian wetlands will increase the overbank storage of sediment and sediment-associated phosphorus (P). Wetland restoration is therefore a cost-effective mitigation measure to reduce the sediment and nutrient transport to river systems. The studied floodplain of the River Odense was restored in 2003 by remeandering the river channel along a 6-km reach. The restoration project involved 78 ha of riparian areas that were transformed from mainly arable land to extensive grassland and wetlands. The aim of the study was to quantify and model sediment and particulate P deposition on restored river floodplains. The present study suggests that during a 47-day flooding period, the river floodplain is able to retain 914.8% of the sediment and 1.13. 7% of the particulate P transported in the river. Incubation experiments further showed that a maximum of 1125% of the deposited phosphorus can be released as dissolved inorganic phosphorus following deposition. The results from the best deposition model (R2 ≤ 0.42 for sediment and R2 ≤ 0.44 for particulate P) show that work should be done to further improve the performance of these models. © CSIRO 2009.
Influence of precursors on the formation of 3‐MCPD and glycidyl esters in a model oil under simulated deodorization conditions

To find new ways for reducing the potential of palm oil to form 3-monochloropropane-1,2-diol (3-MCPD) and glycidyl esters during refining it is helpful to know more about the influence of different precursors like diacylglycerols (DAGs) and monoacylglycerols (MAGs), lecithin, and chlorine containing compounds. After adding increasing amounts of the different precursors to a model oil obtained by removal of polar compounds from crude palm oil and heating the mixture under standardized conditions to 240°C for 2 h the contents of 3-MCPD and glycidyl esters were analyzed according to the standard procedure of DGF C-VI 18 (10). DAGs and MAGs were found to increase the potential of palm oil to form 3-MCPD and glycidyl esters, but refined lecithin showed no influence. Sodium chloride as well as tetra-n-butylammoniumchloride (TBAC) led to higher contents of the esters. Whereas the addition of TBAC raised the amount of glycidyl esters as well as 3-MCPD esters, sodium chloride largely raised the amount of 3-MCPD esters. An addition of 5 mmol of sodium carbonate/kg model oil spiked with sodium chloride reduced the amount of glycidyl esters almost completely; the 3-MCPD esters were reduced by 50%. About 1 mmol sodium hydrogen carbonate/kg oil reduced both 3-MCPD and glycidyl esters almost completely. Practical applications: For the mitigation of the formation of 3-MCPD esters and related compounds in refined edible oils, it is helpful to know more about the effect of different possible precursors. Using a broader data basis, it is possible to adopt the oil processing but especially the choice of the raw material to the demands of the market for lower contents of the esters in the refined products.
Revision Cochlear Implant Surgery

Cochlear Implantation (CI) is now widely accepted as a safe and effective treatment for children and adults with profound deafness. As with all electronic devices, a (CI) is susceptible to breakdown or failure. Although the (CI) reliability rate is now very high, the continually increasing population of implant recipients will result in the continued occurrence of revision surgeries. The first report of a CI revision surgery occurred in 1985, by Hochmair-Desoyer and Burian. Since then, several reports have addressed the safety of this procedure.
Towards a Large-Scale Assessment of the Relationship Between Biological and Chronological Aging: The Inspire Mouse Cohort

Aging is the major risk factor for the development of chronic diseases. After decades of research focused on extending lifespan, current efforts seek primarily to promote healthy aging. Recent advances suggest that biological processes linked to aging are more reliable than chronological age to account for an individual’s functional status, i.e. frail or robust. It is becoming increasingly apparent that biological aging may be detectable as a progressive loss of resilience much earlier than the appearance of clinical signs of frailty. In this context, the INSPIRE program was built to identify the mechanisms of accelerated aging and the early biological signs predicting frailty and pathological aging. To address this issue, we designed a cohort of outbred SWISS mice (1576 male and female mice) in which we will continuously monitor spontaneous and voluntary physical activity from 6 to 24 months of age under either normal or high fat/high sucrose diet. At different age points (6, 12, 18, 24 months), multiorgan functional phenotyping will be carried out to identify early signs of organ dysfunction and generate a large biological fluids/feces/organs biobank (100,000 samples). A comprehensive correlation between functional and biological phenotypes will be assessed to determine: 1) the early signs of biological aging and their relationship with chronological age; 2) the role of dietary and exercise interventions on accelerating or decelerating the rate of biological aging; and 3) novel targets for the promotion of healthy aging. All the functional and omics data, as well as the biobank generated in the framework of the INSPIRE cohort will be available to the aging scientific community. The present article describes the scientific background and the strategies employed for the design of the INSPIRE Mouse cohort.
Lipid Profile Changes in Rheumatoid Arthritis Patients: Investigation of Different Affecting Factors

It has been proved that rheumatoid arthritis (RA) is linked to dyslipidemia and the risk of cardiovascular complications is higher in these patients. The aim of this study was to evaluate dyslipidemia in RA patients. In this study, RA patients were enrolled regarding the inclusion and exclusion criteria. Their demographic information and medication profiles were evaluated. Clinical assessments were performed by evaluation of disease activity score (DAS28) and visual analogue scale. Moreover, laboratory investigations of lipid profile including triglycerides (TG), total cholesterol (Chol), low-density lipoprotein (LDL), and highdensity lipoprotein (HDL) were performed. From a total of 150 patients with the mean age of 54.9±16.8 years, 65.3% were diagnosed with dyslipidemia. Females in menopausal ages had a higher prevalence of dyslipidemia as well as patients with longer disease duration. Mean serum HDL, LDL, Chol, and TG were 52.76±13.8, 96.65±21.6, 177.26±38.9, and 128.04±33.9, respectively. Considering DAS28, 100% of the patients with high disease activity were diagnosed with dyslipidemia. In the moderate and low disease activity groups and also patients in remission, the ratio was 77.02%, 66.66%, and 43.75%, respectively. According to the results, patients under treatment with prednisolone and methotrexate were more affected by dyslipidemia than those with prednisolone, methotrexate, and hydroxychloroquine. Moreover, in the patients under prednisolone, methotrexate, and leflunomide treatment, the prevalence of dyslipidemia was significantly lower than those used only prednisolone and methotrexate. Altogether, it is necessary to have more clinical suspicion towards dyslipidemia and its complications in the patients with a greater number of affecting factors. © 2018 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2018;56(10):665-670.
Association of diabetes and hypertension with elderly skin changes

<p class="abstract"><strong>Background:</strong> The skin is the largest organ of the human body that fulfils multiple essential tasks. It forms the boundary between the inside and outside. It provides protection against mechanical and chemical threats, it provides innate and adaptive immune defences, it enables thermoregulation and vitamin D production, and it acts as the sensory organ of touch. Aging population is susceptible to many cutaneous and systemic diseases, simultaneously leading to impairment of quality of life in them. </p><p class="abstract"><strong>Methods:</strong> A cross sectional study was carried on patients above 60 years of age who visited the dermatology OPD at rural tertiary care centre from November 2016 to May 2017. <strong></strong></p><p class="abstract"><strong>Results:</strong> Total 540 geriatric patients with dermatosis were registered under the study, of these 203 patients had one or more systemic diseases. Hypertension (70.9%) was the commonest disease, followed by diabetes (32.5%). </p><p class="abstract"><strong>Conclusions:</strong> Skin diseases cause considerable morbidity in elderly, particularly if associated with other comorbid conditions, so health promotion and education can do much to reduce the risk. </p><p class="abstract"> </p>
Studies on the Utilization of Full Fat Sunflower Seed in Broiler Rations

Abstract Sunflower seed samples grown locally were analyzed for proximate composition and then fed to broiler chicks in four different feeding trials. Two experiments were conducted in battery cages using semipurified diets and two in conventional floor pens with practical type diets. Whole sunflower seed was tested as full-fat raw (SSFR) or full-fat steamed or heated as a source of protein and energy. Ether extract, calcium, phosphorus, and crude fiber levels in the local sunflower seeds were low when compared to literature values. No significant differences were detected with respect to average body weight, feed consumption, feed efficiency, mortality, or organ weights (liver and pancreas) when full-fat raw or heated sunflower seed was incorporated at the 0, 10, and 20% level in semipurified diets when birds were raised in cages. Neither a detrimental nor a beneficial effect of steaming or dry heating was observed on the utilization of sunflower seed by broilers. There was, however, a significant reduction in body weight at the 30% level of incorporation in semipurified diets. Liver and pancreas weights tended to increase with an increase in the SSFR level in the ration, but the differences were not statistically significant. In broilers raised in floor pens and fed practical type diets, SSFR addition decreased body weights when fed at 15 or 25% of the diet in one of the experiments and feed intake was reduced in both experiments. It was concluded that in practical type broiler rations, SSFR can constitute at least 10% of the ration without any adverse effect on performance.
The Application of Antenna Diversity to NOMA With Statistical Channel State Information

In this paper, antenna diversity is used to improve the outage performance of downlink non-orthogonal multiple access (NOMA) systems combined with single-user multiple-input multiple-output (SU-MIMO) due to the statistical channel state information (CSI), that the transmitter only knows the statistical characteristic associated with each user's channel matrix. We design the precoding and detection vectors, which makes the proposed MIMO-NOMA system reduce to a single-antenna NOMA system with statistical CSI. Next, a dynamic power allocation scheme is proposed to maximize the ergodic sum rate of the considered NOMA group with the minimum ergodic rate constraints of the weaker users. Under this power allocation, we analyze the impact of user clustering and then develop a novel user clustering algorithm. Also, the outage analysis indicates that the proposed system only obtains receive diversity and under the proposed power allocation, the users’ diversity gains are linear with their successive interference cancellation decoding orders. Simulation results confirm our proposed analysis.
Lightweight Certificateless Two-Factor Authentication Protocol Using Smart Cards

User authentication and key agreement in smart cards is a critical issue due to the open and complex wireless communication environment. In order to protect the user’s privacy and sensitive data in smart cards, many two-factor authentication protocols have been proposed, yet most of them cannot withstand various attacks. In this paper, we summarize the security requirements for smart cards and propose a secure lightweight certificateless authentication protocol with password change. Moreover, the proposed protocol satisfies anonymity, mutual authentication and session key agreement as well as resists many attacks. The performance analysis demonstrate that the proposed protocol is secure and highly practical.
The role of rehabilitation in the management of late-onset Pompe disease: a narrative review of the level of evidence

Late-onset Pompe disease (LOPD) is characterized by progressive muscle weakness, respiratory muscle dysfunction, and minor cardiac involvement. Although in LOPD, as in other neuromuscular diseases, controlled low impact sub-maximal aerobic exercise and functional ability exercise can improve general functioning and quality of life, as well as respiratory rehabilitation, the bulk of evidence on that is weak and guidelines are lacking. To date, there is no specific focus on rehabilitation issues in clinical recommendations for the care of patients with Pompe disease, and standard practice predominantly follows general recommendation guidelines for neuromuscular diseases. The Italian Association of Myology, the Italian Association of Pulmonologists, the Italian Society of Neurorehabilitation, and the Italian Society of Physical Medicine and Rehabilitation, have endorsed a project to formulate recommendations on practical, technical, and, whenever possible, disease-specific guidance on rehabilitation procedures in LOPD, with specific reference to the Italian scenario. In this first paper, we review available evidence on the role of rehabilitation in LOPD patients, particularly addressing the unmet needs in the management of motor and respiratory function for these patients.
What influences the structure of frog assemblages at forest streams

We investigated habitat variables influencing the species richness and composition of frog assemblages at forest streams in southeast Queensland, Australia, to (i) determine whether these assemblage attributes can be predicted from the nature of the local habitat, and (ii) assess the value of species richness as a measure of the structure of frog assemblages. Stream size (as measured by the annual volume of precipitation in the upstream catchment) was found to be a significant predictor of the species richness of an assemblage, while stream size, understorey floristics in the riparian zone, the presence of palms and elevation were significantly correlated with the composition of assemblages. No relationship was found between broad forest type and the species richness or composition of frog assemblages. Species richness was not an informative description of the composition of frog assemblages, as assemblages with identical species richness had a low average compositional similarity. Results of this study indicate that frogs are responding to local, ground-level stream and vegetation variables, a finding of both ecological interest and practical significance for the conservation management of forest-dwelling frogs.
Determining Rheumatology Patient Interest in a Group Strength Training Program - Results of an Exercise Survey

Background: Exercise has proven benefits in rheumatologic disease including reducing inflammation and improving symptoms. A Group Strength Training (GST) program design has improved adherence to exercise in primary care patients but the effect is unknown in rheumatology patients. We examined the interest of rheumatology patients with different diagnoses and the effect of comorbidities in pursuing an organized GST program. Methods: We conducted a cross-sectional survey of patients from a rheumatology practice in central Pennsylvania in February and April 2017. This survey assessed self-reported interest of patients in a GST program in addition to demographics, comorbidities, and quality of life measures. Primary care data from a previous survey were used for comparative analysis for the primary outcome: interest in a GST program. Results: Fifty percent of rheumatology patients were interested in a GST program and there was no difference of interest compared to primary care patients (X2 = 2.04, p = 0.15). There was no difference in interest in a GST program for rheumatology patients with poor health compared to patients with good health (OR = 0.9, p = 0.8). Female patients were more interested in a group strength training program than male patients (OR = 3.7, p = 0.001). Patients with a BMI of 25–30 (OR = 2.2, p = 0.04) or > 30 (OR = 1.7, p = 0.12) were more interested compared to those with a normal BMI. There was no difference in interest in group strength training regardless of rheumatology diagnosis or comorbidities. Conclusion: Our data suggest that rheumatology patients are interested in a GST program regardless of disease, medical comorbidities, perceived mental or physical health, or education level. Further study is needed to determine the effects of GST on rheumatologic diseases.
Adult Intussusception Due to Inflammatory Fibroid Polyp - Vanek's Tumour

Adult intussusception is a rare disease, found 5% of all cases of intussusceptions and almost 1%-5% of bowel obstruction. In adults, intussusception is typically due to a pathologic lead point within the bowel, which is malignant in over 50% of cases. Inflammatory fibroid polyp (also known as Vanek' stumour) is an uncommon, non-neoplastic proliferating lesion which can develop in various parts of the gastro-intestinal tract but most commonly in the gastric antrum and the ileum. Here we present a case of 35 years old lady with symptoms intermittent lower abdominal pain. USG of abdomen revealed as right adnexal complex cyst with thicken gut wall. She was underwent laparotomy and found ileo-ileal intussusception but no adnexal pathology. Segmental resection done where histopathology reported as loops of intussusception containing inflammatory fibroid polyp. KYAMC Journal Vol. 9, No.-4, January 2019, Page 190-193