Miracle-dz/UniFAR-FTUs huggingface dataset:
Coping moderates the relationship between intolerance of uncertainty and stress in men during the Covid-19 pandemic

Abstract Objective: To test the explanatory power of coping strategies and intolerance of uncertainty on men’s perceived stress levels and test the moderating role of coping strategies in the relationship between intolerance of uncertainty and perceived stress during the Covid-19 pandemic. Method: This was an online cross-sectional study in which 1,006 men living in Brazil during the Covid-19 pandemic participated. Participants were recruited using a snowball sampling technique and completed a questionnaire containing measures of all study variables. Data were examined using a correlation and a regression analysis. Results: Intolerance of uncertainty (β = .51) and refusal (β = .15) positively predicted perceived stress, whereas control (β = –.31) and isolation (β = –.06) negatively predicted it. Together, these variables explained 52% of men’s perceived stress (p < .001). Isolation and social support lessened the relationship between intolerance of uncertainty and stress (p < .001). Conclusion: Men high in intolerance of uncertainty and refusal were more vulnerable to stress during the pandemic. However, coping helped mitigate the relationship between intolerance of uncertainty and perceived stress, thus being a promising psychosocial intervention in this context.
Surface and human contamination with 5-fluorouracil in six hospital pharmacies

The level of contamination by the fluorouracil in drug preparation was determined in six hospital pharmacies, three using hoods and three using isolators for the preparation of antineoplastic agents. Contamination by 5-fluorouracil of the work environment as well as the protective shield was mesured by high-performance liquid chromatography with UV detection. Extraction was realized from 1 mL sample with 2 mL mixture. Measurable amounts of 5-fluorouracil were detected in 83 % (10/12) of the samples in protective shield for isolator against 8.3 % (1/12) for hood. The protective shields of isolators were contaminated even after cleaning. Contamination of the work environment was found for three samples among 75 for hood and 35 samples among 72 for isolators. The isolator gloves (Neoprene), the manipulator suit and the sleeve were potentially permeable. This type of study shows that exposure of manipulators to cytotoxic agents can be controlled only if all the possible sources of contamination are identified and if suitable systems of protection are used. Analysis of surface samples of work environment and of the surface of preparations should be inclued in the validation procedure.
Groundwater quality and health assessments based on heavy metals and trace elements content in Dakhla Oasis, New Valley Governorate, Egypt

ABSTRACT This study is searching for some crucial physicochemical properties of groundwater samples collected from eleven outlets in Dakhla Oasis, Egypt, including the pH-value, electrical conductivity (EC), total dissolved solids (TDS), in addition to the concentrations of heavy metals and trace elements. In total 21 elements were analyzed using inductively coupled plasma spectrometry (ICP-OES). To categorize the water class: Chronic daily intakes (CDI), water quality index (WQI) and hazard risk (HR) were computed for the 21 elements in the water samples. Some biological parameters such as levels of urea, creatinine, and the tumor marker CEA were measured. The obtained results showed that the pH-values (6.12 to 6.56) for water samples are within the acceptable limits of the WHO. Results showed, also, that EC (274 to 532 μS/cm), TDS (175 to 340 ppm) besides, the level of measured 21 elements were lower than the values allowed by World Health Organization (WHO) and US Environmental Protection Agency (USEPA). Additionally, the reached data were comparable to other internationally published figures. It is emphasized that the data obtained for WQI confirmed that water from all the sampling points was of expedient quality. Based on the obtained data and the evaluated parameters, it can be concluded that the groundwater samples of the studied areas are of excellent quality; they do not pose any health risks to the local citizens, and are safe for their domestic consumption. Moreover, the results of urea, creatinine, and CEA analyses showed very few abnormal cases, which confirmed, again, that the groundwater in the studied areasdid not pose a risk to human health.
A Group Intervention to Promote Resilience in Nursing Professionals: A Randomised Controlled Trial

In this study, a new group intervention program to foster resilience in nursing professionals was tested for efficacy. In total, 72 nurses were recruited and randomised to either an intervention condition or to a wait list control condition. The study had a pre-test, post-test, follow-up design. The eight-week program targeted six resilience factors: cognitive flexibility, coping, self-efficacy, self-esteem, self-care, and mindfulness. Compared to the control group, the intervention group reported a significant improvement in the primary outcome mental health (measured with the General Health Questionnaire) from pre-test (M = 20.79; SD = 9.85) to post-test (M = 15.81; SD = 7.13) with an estimated medium effect size (p = 0.03, η2 = 0.08) at post-test. Further significant improvements were found for resilience and other resilience related outcomes measures. The individual stressor load of the subjects was queried retrospectively in each measurement. Stress levels had a significant influence on mental health. The intervention effect was evident even though the stress level in both groups did not change significantly between the measurements. Follow-up data suggest that the effects were sustained for up to six months after intervention. The resilience intervention reduced mental burden in nurses and also positively affected several additional psychological outcomes.
Understanding Behavioral and Physiological Changes associated with Repetitive Lifting and Vibration Exposure

ii Dedication vi Acknowledgments vii Vita ix List of Tables xv List of Figures xvii Chapter 1: Introduction 1 1.1 Epidemiology of Low Back Pain 1 1.2 Risk Factors to Low back pain 2 1.3 Muscle Fatigue 18 1.4 Muscle Fatigue and Adaptations 25 1.5 Conceptual Model 31 1.6 Specific Aims 33 Chapter 2: Physiological and Biomechanical Responses to a Prolonged Repetitive Asymmetric Lifting Activity 36 2.
Real-world effectiveness of dimethyl fumarate versus fingolimod in a cohort of patients with multiple sclerosis using standardized, quantitative outcome metrics

Background Prior studies suggest comparable effectiveness of dimethyl fumarate (DMF) and fingolimod (FTY) in multiple sclerosis (MS) using relapse, Expanded Disability Status Scale (EDSS), and magnetic resonance imaging (MRI) lesion metrics. Objective Compare the real-world effectiveness of DMF versus FTY using quantitative, validated neuroperformance tests, MRI, and serum neurofilament light chain (sNfL) outcomes while controlling for between-group differences. Methods Patients were eligible if on DMF or FTY when first enrolled in the MS Partners Advancing Technology and Health Solutions (MS PATHS) network and had ≥1-year follow-up in MS PATHS. Sensitivity analysis included a subgroup who started DMF/FTY ≤2 years from enrolment. After propensity score weighting, differences in means and in mean 1-year change of neuroperformance and MRI outcomes were compared. sNfL levels were assessed. This was a non-randomized comparison. Results In the overall cohort, no significant differences were observed between DMF (n = 702) and FTY (n = 600) in neuroperformance or MRI outcomes including brain volume loss; mean time (SD) since treatment initiation was 1.98 (0.68) years for DMF and 2.02 (0.75) years for FTY. A sensitivity analysis controlling for DMF and FTY treatment duration yielded similar results. Conclusion In this study, DMF and FTY demonstrated similar effects on physical and cognitive neuroperformance and MRI outcomes. Direct comparisons to other fumarates and S1P receptor modulators were not conducted.
Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions

Green nanotechnology is now accepted as an environmentally friendly and cost-effective advance with various biomedical applications. The cyanobacterium Synechocystis sp. is a unicellular spherical cyanobacterium with photo- and hetero-trophic capabilities. This study investigates the ability of this cyanobacterial species to produce silver nanoparticles (AgNPs) and the wound-healing properties of the produced nanoparticles in diabetic animals. Methods: UV–visible and FT-IR spectroscopy and and electron microscopy techniques investigated AgNPs’ producibility by Synechocystis sp. when supplemented with silver ion source. The produced AgNPs were evaluated for their antimicrobial, anti-oxidative, anti-inflammatory, and diabetic wound healing along with their angiogenesis potential. Results: The cyanobacterium biosynthesized spherical AgNPs with a diameter range of 10 to 35 nm. The produced AgNPs exhibited wound-healing properties verified with increased contraction percentage, tensile strength and hydroxyproline level in incision diabetic wounded animals. AgNPs treatment decreased epithelialization period, amplified the wound closure percentage, and elevated collagen, hydroxyproline and hexosamine contents, which improved angiogenesis factors’ contents (HIF-1α, TGF-β1 and VEGF) in excision wound models. AgNPs intensified catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities, and glutathione (GSH) and nitric oxide content and reduced malondialdehyde (MDA) level. IL-1β, IL-6, TNF-α, and NF-κB (the inflammatory mediators) were decreased with AgNPs’ topical application. Conclusion: Biosynthesized AgNPs via Synechocystis sp. exhibited antimicrobial, anti-oxidative, anti-inflammatory, and angiogenesis promoting effects in diabetic wounded animals.
Cold storage of Spodoptera litura eggs and Telenomus remus adults for improving mass‐rearing efficiency

Telenomus remus (Nixon) has shown promising potential as a biological control agent for the major invasive agricultural pest, Spodoptera frugiperda (J. E. Smith). Application of biological control programmes in the field requires an efficient mass‐rearing system to provide sufficient numbers of beneficial insects. The short longevity of parasitoid adults and limited period of availability of host eggs are two factors affecting the mass‐rearing efficiency of T. remus. Using Spodoptera litura (Fabricius) eggs as an alternative host, the effects of cold storage of S. litura eggs and T. remus adults at 5°C, 8°C and 11°C for different time durations on the fitness of the parasitoid were investigated to identify the most suitable storage conditions. Results showed that T. remus can successfully exploit stored S. litura eggs, but the number of parasitized eggs decreased with increased egg storage duration and/or reduced storage temperature. For refrigerated adults, the survival rate declined gradually with longer storage duration, and the females' survival rate was higher than the males' at any treatment. Similarly, parasitism capacity of stored adults declined significantly with prolonged storage. Female adult longevity was significantly shorter than the control for all treatments. However, the offspring emergence rate and percentage of females were barely affected by cold storage. In conclusion, S. litura eggs can be stored at 11°C for up to 9 days and adult T. remus can be stored at 8°C or 11°C for up to 7 days without significant losses. Data obtained from this study will help coordinate different aspects of T. remus production, decreasing costs and improving the biocontrol materials' availability.
TRAPing Ghrelin-Activated Circuits: A Novel Tool to Identify, Target and Control Hormone-Responsive Populations in TRAP2 Mice

The availability of Cre-based mouse lines for visualizing and targeting populations of hormone-sensitive cells has helped identify the neural circuitry driving hormone effects. However, these mice have limitations and may not even be available. For instance, the development of the first ghrelin receptor (Ghsr)-IRES-Cre model paved the way for using the Cre-lox system to identify and selectively manipulate ghrelin-responsive populations. The insertion of the IRES-Cre cassette, however, interfered with Ghsr expression, resulting in defective GHSR signaling and a pronounced phenotype in the homozygotes. As an alternative strategy to target ghrelin-responsive cells, we hereby utilize TRAP2 (targeted recombination in active populations) mice in which it is possible to gain genetic access to ghrelin-activated populations. In TRAP2 mice crossed with a reporter strain, we visualized ghrelin-activated cells and found, as expected, much activation in the arcuate nucleus (Arc). We then stimulated this population using a chemogenetic approach and found that this was sufficient to induce an orexigenic response of similar magnitude to that induced by peripheral ghrelin injection. The stimulation of this population also impacted food choice. Thus, the TRAPing of hormone-activated neurons (here exemplified by ghrelin-activated pathways) provides a complimentary/alternative technique to visualize, access and control discrete pathways, linking hormone action to circuit function.
Impact of Eastern and Central Pacific El Niño on Lower Tropospheric Ozone in China

Abstract. Tropospheric ozone is an essential atmospheric component as it plays a significant role in influencing radiation equilibrium and ecological health. It is affected not only by anthropogenic activities but also by natural climate variabilities. Here we examine the tropospheric ozone change in China associated with the Eastern Pacific (EP) and Central Pacific (CP) El Niño using satellite observations from 2007 to 2017 and GEOS-Chem simulations from 1980 to 2017. GEOS-Chem simulations reasonably reproduce the satellite-retrieved lower tropospheric ozone (LTO) changes despite a slight underestimation. Results show that El Niño generally exerts negative impacts on LTO concentration in China, except for southeastern China during the pre-CP El Niño autumn and post-EP El Niño summer. The budget analysis further indicates that for both events, LTO changes are dominated by the transport process controlled by circulation patterns and the chemical process influenced by local meteorological anomalies associated with El Niño, especially the solar radiation and relative humidity changes. The differences between EP and CP-induced LTO changes mostly lie in southern China. The different strengths, positions, and duration of western North Pacific anomalous anticyclone (WNPAC) induced by tropical warming are likely responsible for the different EP and CP LTO changes. During the post-EP El Niño summer, the Indian ocean capacitor also plays an important role in controlling LTO changes over southern China.
Computational Approach for the Fluid-Structure Interaction Design of Insect-Inspired Micro Flapping Wings

A flight device for insect-inspired flapping wing nano air vehicles (FWNAVs), which consists of the micro wings, the actuator, and the transmission, can use the fluid-structure interaction (FSI) to create the characteristic motions of the flapping wings. This design will be essential for further miniaturization of FWNAVs, since it will reduce the mechanical and electrical complexities of the flight device. Computational approaches will be necessary for this biomimetic concept because of the complexity of the FSI. Hence, in this study, a computational approach for the FSI design of insect-inspired micro flapping wings is proposed. This approach consists of a direct numerical modeling of the strongly coupled FSI, the dynamic similarity framework, and the design window (DW) search. The present numerical examples demonstrated that the dynamic similarity framework works well to make different two FSI systems with the strong coupling dynamically similar to each other, and this framework works as the guideline for the systematic investigation of the effect of characteristic parameters on the FSI system. Finally, an insect-inspired micro flapping wing with the 2.5-dimensional structure was designed using the proposed approach such that it can create the lift sufficient to support the weight of small insects. The existing area of satisfactory design solutions or the DW increases the fabricability of this wing using micromachining techniques based on the photolithography in the micro-electro-mechanical systems (MEMS) technology. Hence, the proposed approach will contribute to the further miniaturization of FWNAVs.
Developing and Validating a Facial Emotion Recognition Task With Graded Intensity

Facial emotion recognition (FER) tasks are often digitally altered to vary expression intensity; however, such tasks have unknown psychometric properties. In these studies, an FER task was developed and validated—the Graded Emotional Face Task (GEFT)—which provided an opportunity to examine the psychometric properties of such tasks. Facial expressions were altered to produce five intensity levels for six emotions (e.g., 40% anger). In Study 1, 224 undergraduates viewed subsets of these faces and labeled the expressions. An item selection algorithm was used to maximize internal consistency and balance gender and ethnicity. In Study 2, 219 undergraduates completed the final GEFT and a multimethod battery of validity measures. Finally, in Study 3, 407 undergraduates oversampled for borderline personality disorder (BPD) completed the GEFT and a self-report BPD measure. Broad FER scales (e.g., overall anger) demonstrated evidence of reliability and validity; however, more specific subscales (e.g., 40% anger) had more variable psychometric properties. Notably, ceiling/floor effects appeared to decrease both internal consistency and limit external validity correlations. The findings are discussed from the perspective of measurement issues in the social cognition literature.
Cardiac implications of upper-arm arteriovenous fistulas: A case series

Background: Cardiovascular disease is a major cause of morbidity and mortality in patients with end-stage kidney disease. Arterio-venous fistulas (AVF), the gold standard for hemodialysis vascular access, are known to alter cardiac morphology and circulatory hemodynamics. We present a prospective case series of patients after creation of an AVF, explore the timeline for changes in their cardiac morphology, and detail considerations for clinicians. Methods: Patients were recruited in 2010 at multiple centers immediately prior to the creation of an upper-arm AVF and the initiation of hemodialysis. Cardiovascular magnetic resonance images were taken at intake before the creation of the AVF, 6-month follow-up, and 12-month follow-up. Image segmentation was used to measure left ventricular volume and mass, left atrial volume, and ejection fraction. Results: Eight patients met eligibility criteria. All eight patients had a net increase in left ventricular mass over enrollment, with a mean increase of 9.16 g (+2.96 to +42.66 g). Five participants had a net decrease in ejection fraction, with a mean change in ejection fraction of −5.4% (−21% to +5%). Upon visual inspection the patients with the largest ejection fraction decrease had noticeably hypertrophic and dilated ventricles. Left atrial volume change was varied, decreasing in five participants, while increasing in three participants. Changes in morphology were present at 6-month follow-up, even in patients who did not maintain AVF patency for the entirety of the 6-month period. Conclusion: All patients included in this prospective case series had increases in left ventricular mass, with variability in the effects on the ejection fraction and left atrial volume. As left ventricular mass is an independent predictor of morbidity and mortality, further research to determine appropriate vascular access management in both end-stage kidney disease and kidney transplant populations is warranted.
Evaluation of Three Automated Extraction Systems for the Detection of SARS-CoV-2 from Clinical Respiratory Specimens

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is highly contagious and causes coronavirus disease 2019 (COVID-19). Reverse transcription quantitative polymerase chain reaction (RT-qPCR) is the most accurate and reliable molecular assay to detect active SARS-CoV-2 infection. However, a rapid increase in test subjects has created a global bottleneck in testing capacity. Given that efficient nucleic acid extraction greatly affects reliable and accurate testing results, we compared three extraction platforms: MagNA Pure 96 DNA and Viral NA Small Volume kit on MagNA Pure 96 (Roche, Basel, Switzerland), careGENETM Viral/Pathogen HiFi Nucleic Acid Isolation kit (WELLS BIO Inc., Seoul, Korea) on KingFisher Flex (Thermo Fisher Scientific, Rocklin, CA, USA), and SGRespiTM Pure kit (Seegene Inc., Seoul, Korea) on Maelstrom 9600 (Taiwan Advanced Nanotech Inc., Taoyuan, Taiwan). RNA was extracted from 245 residual respiratory specimens from the different types of samples (i.e., NPS, sputum, and saliva) using three different kits. The 95% limits of detection of median tissue culture infectious dose per milliliter (TCID50/mL) for the MagNA Pure 96, KingFisher Flex, and Maelstrom 9600 were 0.37–3.15 × 101, 0.41–3.62 × 101, and 0.33–1.98 × 101, respectively. The KingFisher Flex platform exhibited 99.2% sensitivity and 100% specificity, whereas Maelstrom 9600 exhibited 98.3–100% sensitivity and 100% specificity. Bland–Altman analysis revealed a 95.2% concordance between MagNA Pure 96 and KingFisher Flex and 95.4% concordance between MagNA Pure 96 and Maelstrom 9600, indicating that all three platforms provided statistically reliable results. This suggests that two modifying platforms, KingFisher Flex and Maelstrom 9600, are accurate and scalable extraction platforms for large-scale SARS-CoV-2 clinical detection and could help the management of COVID-19 patients.
Kinetics Modelling of Pseudomonas stutzeri strain DN2 Growth Behaviour in Tributyltin Chloride

A predictive model was performed to describe Pseudomonas stutzeri strain DN2 growth behaviour in tributyltin chloride, using primary Modelling and a polynomial model as a secondary predictive model. In this investigation, data predicted using the modified Logistic (ML) was the most accurate. The Bias Factor (Bf) and Accuracy Factor (Af) values for the (ML) model were 1.39 and 1.51, indicating that the predictions were within a reliable range. The low RMSE value of 0.14, R2 and adj R2 (0.99) value closer to 1, showing that modified logistics is better than the other models at describing the growth behaviour of Pseudomonas stutzeri strain DN2 in toxic tributyltin chloride. Both the Aiba and Haldane models on the other hand, among the secondary model best fit the behaviours having low RMSE and MSE values and adjR2 value closer to 1. In this study, the primary and secondary kinetics of Pseudomonas stutzeri strain DN2 growth behaviour in tributyltin chloride was explored and it was shown in this study that the modified logistic and the Haldane models better suit the growth behavior of Pseudomonas stutzeri strain DN2 in tributyltin chloride. The parameters obtained from the modelling exercise will be very valuable in transferring the laboratory results to the field.