Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk of Stroke in Liver Cirrhosis

Background and Aims: Liver cirrhosis can lead to abnormal coagulation, rendering patients at risk for bleeding but also thrombotic complications. We conducted a systematic review and meta-analysis to explore the epidemiology of stroke in liver cirrhosis and the potential association between them. Materials and Methods: Studies were searched through the PubMed, EMBASE, and Cochrane Library databases. Incidence and prevalence of unspecific stroke, hemorrhagic stroke, intracranial hemorrhage, subarachnoid hemorrhage, and ischemic stroke were pooled by using a random-effect model. Meta-regression analyses were employed to explore the sources of heterogeneity. As for the cohort studies, hazard ratios (HRs) with 95% CIs were pooled to evaluate the association between liver cirrhosis and stroke. Results: Twenty-seven studies with 93,191 cirrhotic patients were included, of which 23 explored the incidence and 10 explored the prevalence. The pooled incidence of unspecific stroke, hemorrhagic stroke, intracranial hemorrhage, and ischemic stroke was 4.1%, 1.3%, 2.0%, and 3.7%, respectively. The pooled prevalence of unspecific and ischemic stroke was 9.0% and 2.6%, respectively. Heterogeneity among studies was significant in most of meta-analyses. Meta-regression analyses indicated that the sample size might explain the potential source of heterogeneity (P=0.018). Liver cirrhosis significantly increased the risk of subarachnoid (HR=2.36; 95% CI, 1.80-3.09; P=0.000) and intracranial hemorrhage (HR=1.48; 95% CI, 1.06-2.05; P=0.020), but not unspecific (HR=1.02; 95% CI, 0.49-2.14; P=0.960), ischemic (HR=0.79; 95% CI, 0.46-1.35; P=0.380), or hemorrhagic stroke (HR=1.88; 95% CI, 0.52-6.81; P=0.335). Conclusions: Stroke is uncommon in cirrhotic patients. However, considering a positive relationship of liver cirrhosis with subarachnoid and intracranial hemorrhage, the prophylactic strategy may be selectively adopted in cirrhotic patients.
Long-Term Consumption of Sugar-Sweetened and Artificially Sweetened Beverages and Risk of Mortality in US Adults

Background: Whether consumption of sugar-sweetened beverages (SSBs) or artificially sweetened beverages (ASBs) is associated with risk of mortality is of public health interest. Methods: We examined associations between consumption of SSBs and ASBs with risk of total and cause-specific mortality among 37 716 men from the Health Professional’s Follow-up study (from 1986 to 2014) and 80 647 women from the Nurses’ Health study (from 1980 to 2014) who were free from chronic diseases at baseline. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals. Results: We documented 36 436 deaths (7896 cardiovascular disease [CVD] and 12 380 cancer deaths) during 3 415 564 person-years of follow-up. After adjusting for major diet and lifestyle factors, consumption of SSBs was associated with a higher risk of total mortality; pooled hazard ratios (95% confidence intervals) across categories (<1/mo, 1–4/mo, 2–6/week, 1-<2/d, and ≥2/d) were 1.00 (reference), 1.01 (0.98, 1.04), 1.06 (1.03, 1.09), 1.14 (1.09, 1.19), and 1.21 (1.13, 1.28; P trend <0.0001). The association was observed for CVD mortality (hazard ratio comparing extreme categories was 1.31 [95% confidence interval, 1.15, 1.50], P trend <0.0001) and cancer mortality (1.16 [1.04, 1.29], P trend =0.0004). ASBs were associated with total and CVD mortality in the highest intake category only; pooled hazard ratios (95% confidence interval) across categories were 1.00 (reference), 0.96 (0.93, 0.99), 0.97 (0.95, 1.00), 0.98 (0.94, 1.03), and 1.04 (1.02, 1.12; P trend = 0.01) for total mortality and 1.00 (reference), 0.93 (0.87, 1.00), 0.95 (0.89, 1.00), 1.02 (0.94, 1.12), and 1.13 (1.02, 1.25; P trend = 0.02) for CVD mortality. In cohort-specific analysis, ASBs were associated with mortality in NHS (Nurses’ Health Study) but not in HPFS (Health Professionals Follow-up Study) (P interaction, 0.01). ASBs were not associated with cancer mortality in either cohort. Conclusions: Consumption of SSBs was positively associated with mortality primarily through CVD mortality and showed a graded association with dose. The positive association between high intake levels of ASBs and total and CVD mortality observed among women requires further confirmation.
The gender conformity conundrum: The effects of irrelevant gender norms on public conformity

ABSTRACT The purpose of this experiment was to examine influences of gender norms on gender-role conformity. This series of two studies tests whether females or males are more likely to conform to public norms. To test this, we attached men’s and women’s bathroom-type signs to exit doors from a café at a private academic institution in upstate New York. We then unobtrusively observed whether individuals chose to exit through the door matching their gender. We found that, in both studies, males conformed more to their gender-role sign than did females. This suggests that conformity to certain gender and social norms has greater influence on males, and that these norms have a substantial power over decisions in social settings. In addition, it may be that some males conform to these norms to avoid being represented or perceived as female and/or a lower-power member of society.
Relationship of early-life residence and educational experience to level and change in cognitive functioning: Results of the Minority Aging Research Study.

OBJECTIVE Investigate associations of early-life residence and school segregation with cognitive change in the Minority Aging Research Study. METHODS 498 Blacks (age~73.5;75%=female) without dementia at baseline self-reported State of birth, residence at age 12, and school segregation status. Census Bureau definitions of South and Northeast/Midwest were used to categorize early-life residence. We evaluated global cognition and 5 cognitive domains at baseline and annually for ~7.5 years. Linear mixed-effects models examined the associations of region of birth and residence at age 12 with baseline level and longitudinal change in cognition. Additional models examined school segregation experience. RESULTS ~65% of Southern born participants still lived in the South at age 12. Southern birth was associated with lower baseline global cognition and all cognitive domains (p-values<0.02) compared to Northern birth, but not cognitive change. A similar profile was seen for Southern residence at age 12. Segregation experience significantly modified associations of residence at age 12 on levels of cognition. Participants residing in the South attending a legally desegregated school demonstrated lower baseline levels of cognition (global, semantic, and working memory) than their Northeast/Midwest counterparts attending a legally desegregated or segregated school as well as their Southern counterparts attending a legally segregated school. This profile for participants attending a desegregated school in the South held for processing speed and visuospatial ability in comparisons to Northeast/Midwest counterparts, particularly those attending a legally desegregated school. CONCLUSION Baseline cognition was poorer in individuals born and residing in the South, particularly those attending desegregated schools at age 12.
Effect of Neurally Adjusted Ventilatory Assist on Patient-Ventilator Interaction in Mechanically Ventilated Adults: A Systematic Review and Meta-Analysis.

OBJECTIVES Patient-ventilator asynchrony is common among critically ill patients undergoing mechanical ventilation and has been associated with adverse outcomes. Neurally adjusted ventilatory assist is a ventilatory mode that may lead to improved patient-ventilator synchrony. We conducted a systematic review to determine the impact of neurally adjusted ventilatory assist on patient-ventilator asynchrony, other physiologic variables, and clinical outcomes in adult patients undergoing invasive mechanical ventilation in comparison with conventional pneumatically triggered ventilatory modes. DATA SOURCES We searched Medline, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central, CINAHL, Scopus, Web of Science, conference abstracts, and ClinicalTrials.gov until July 2018. STUDY SELECTION Two authors independently screened titles and abstracts for randomized and nonrandomized controlled trials (including crossover design) comparing the occurrence of patient-ventilator asynchrony between neurally adjusted ventilatory assist and pressure support ventilation during mechanical ventilation in critically ill adults. The asynchrony index and severe asynchrony (i.e., asynchrony index > 10%) were the primary outcomes. DATA EXTRACTION Two authors independently extracted study characteristics and outcomes and assessed risk of bias of included studies. DATA SYNTHESIS Of 11,139 unique citations, 26 studies (522 patients) met the inclusion criteria. Sixteen trials were included in the meta-analysis using random effects models through the generic inverse variance method. In several different clinical scenarios, the use of neurally adjusted ventilatory assist was associated with significantly reduced asynchrony index (mean difference, -8.12; 95% CI, -11.61 to -4.63; very low quality of evidence) and severe asynchrony (odds ratio, 0.42; 95% CI, 0.23-0.76; moderate quality of evidence) as compared with pressure support ventilation. Furthermore, other measurements of asynchrony were consistently improved during neurally adjusted ventilatory assist. CONCLUSIONS Neurally adjusted ventilatory assist improves patient-ventilator synchrony; however, its effects on clinical outcomes remain uncertain. Randomized controlled trials are needed to determine whether the physiologic efficiency of neurally adjusted ventilatory assist affects patient-important outcomes in critically ill adults.
Trends in status of hypertension in rural northeast China: results from two representative cross-sectional surveys, 2013-2018.

OBJECTIVE To investigate the long-term natural trends in the status of hypertension in rural northeast China from 2013 to 2018. METHODS Two successive cross-sectional surveys were conducted in Liaoning rural areas in 2013 and 2018, which included 10 753 and 10 926 participants aged at least 40 years from different villages, respectively. A multistage, stratified, and cluster random sampling method was used to ensure that the samples of the two studies were representative. Hypertension was defined as a mean SBP at least 140 mmHg or a mean DBP at least 90 mmHg, and/or self-reported use of antihypertensive medication within the past 2 weeks. The prevalence and control rate of hypertension were also estimated according to the 2017 American College of Cardiology/American Heart Association high blood pressure guideline. RESULTS Overall, the age-standardized prevalence of hypertension increased from 52.3 to 53.6%, while the age-specified DBP level increased by 5.2% (82.4 vs. 86.7 mmHg) during the study period. However, the control rate unfortunately remained low (4.1 vs. 3.6%), despite unsatisfied awareness and treatment rates of hypertension in rural northeast China. Under the 2017 American College of Cardiology/American Heart Association guideline, the prevalence of hypertension increased from 73.9 to 79.1%; however, the control rate decreased sharply from 1.8 to 0.5% between 2013 and 2018. CONCLUSION Despite the high prevalence of hypertension during the past 5 years, blood pressure levels increased significantly, especially the DBP level. Awareness, treatment, and control of hypertension remained unacceptably low. Therefore, strategies targeting the management of hypertension should be emphasized in rural northeast China.
Single-tunnel anatomic double-bundle anterior cruciate ligament reconstruction has the same effectiveness as double femoral, double tibial tunnel

Purpose: To investigate whether single femoral, single tibial tunnel anatomic double-bundle anterior cruciate ligament (ACL) reconstruction is equal to or superior to double femoral, double tibial tunnel ACL double-bundle anatomic reconstruction in terms of restoring the stability and functions of the knee joint. Methods: A prospective clinical study was performed to compare 30 cases of single-tunnel ACL double-bundle anatomic reconstruction to 28 cases of double-tunnel ACL double-bundle anatomic reconstruction, with average follow-up of 36 months. All graft tendons were hamstring tendon autografts. Tunnel placements in all the cases were made anatomically. Clinical results were collected after reconstruction. Graft appearance, meniscus status and cartilage state under arthroscopy were compared and analyzed. Results: Tunnel placements were in the anatomic positions in both groups. On the lateral pivot-shift test performed at 36 months postoperatively, there was no significant difference between groups. Clinical results such as International Knee Documentation Committee score, Tegner activity scale, and range of motion showed no significant differences between the groups. The mean thickness of anteromedial graft was reduced by 10.3% and that of the posterolateral graft was reduced by 11.1% from the original graft thickness evaluated by magnetic resonance imaging. No new meniscal tears were found either group; however, cartilage damage occurred in the double-tunnel group at 39.3%, and this rate was significantly higher than that in the single-tunnel group (10.0%). Conclusion: Single femoral, single tibial tunnel anatomic double-bundle ACL reconstruction has the same effectiveness as the double femoral, double tibial tunnel in restoring the knee's stability and functions.
Cultures of volunteer care? A comparative study of Australia and Denmark

This article seeks to understand two puzzling findings from a comparative study of volunteer care work: that volunteers in Denmark are perceived to be cost-adding, while volunteers in Australia are perceived to be cost-saving; and that volunteers in Australia are perceived to be better than paid workers, while volunteers in Denmark are considered second-best to paid workers. Using a ‘cultures of care’ framework, this article explores whether these articulations reflect on culturally determined care ideals. The findings suggest that different cultures of care exist. Differences are explained by the development of the two welfare states.
Translating Scientific Articles to the Non-scientific Public Using the Wikipedia Encyclopedia

The multilingual, web-based Wikipedia free Encyclopedia is used worldwide by people from different audience. It is openly editable, allowing quick updates. We used these properties as an educational tool in University classrooms, where students’ assignment was to rephrase scientific articles for the public. We share here our teaching experience with an Earth Sciences class, based on class assessments and students evaluations. During the 2017 Fall semester, a 1 ECTS MSc level reading seminar on the broad topic of Heat and Mass Transfers in Magmatology was taught for 6 weeks at ETH Zurich. Three first semester and six third semester M.Sc. students have attended the course. All students had a B.Sc. degree in Earth Sciences, among which seven had their main specialisation in Mineralogy and Geochemistry and two had their major in Geophysics. By groups of two, students have read a scientific article, presented it orally to classmates and answered questions from their peers. During the last two classes, students have edited and created Wikipedia Encyclopedia pages in relation to their article’s topic. Students really enjoyed creating a Wikipedia page, even if they didn’t use it before or didn’t trust the Wikipedia content. They had little experience with communication to a non-scientific audience and considered this exercise was challenging. Evaluations show that writing about a scientific paper in a Wikipedia page is a less efficient learning technique than reading a scientific article, presenting it orally or listening to such a presentation. However, it certainly contributes to better memorise important information, it is an efficient way to practice writing and public and scientific communication skills and it encourages students to work collaboratively on real-time projects. The teachers can use those combined effects as a multi-channel learning technique. It is also highly motivating for the students and the teacher to have a class exercise using modern media techniques with the potential to reach a wide international community. With this article, we wish to encourage colleagues to teach students how to communicate science, to scientific peers and to the non-scientific public. This promotes high-quality education and helps reducing inequality, two sustainable development global goals.
Interaction of Serum-Derived and Internalized C3 With DNA in Human B Cells—A Potential Involvement in Regulation of Gene Transcription

Beside its classical role as a serum effector system of innate immunity, evidence is accumulating that complement has an intracellular repertoire of components that provides not only immune defense, but also functions to maintain cellular homeostasis. While complement proteins, mainly the central component C3, have been detected in B cells, their exact function and source remain largely unexplored. In this study, we investigated the expression and origin of intracellular C3 in human B cells together with its role in B cell homeostasis. Our data provide evidence that endogenous expression of C3 is very low in human B cells and, in accordance with the recent publication, the main origin of intracellular C3 is the serum. Interestingly, we found that both serum-derived and purified C3 are able to enter the nucleus of viable B cells, suggesting its potential involvement in regulation of gene transcription. ELISA, gel shift assay, confocal microscopy, and chromatin immunoprecipitation proved that C3 and C3a strongly bind to nuclear DNA, and among the interacting genes there are key factors of lymphocyte development and differentiation. The strong interaction of C3 with histone proteins and its potential ability to induce chromatin rearrangement suggest that C3/C3a might regulate DNA transcription via chromatin remodeling. Our data reveal a novel, hitherto undescribed role of C3 in immune cell homeostasis, which further extends the repertoire how complement links innate and adaptive immunity and regulates basic processes of the cells.
Bags of Tricks and A Strong Baseline for Deep Person Re-identification.

This paper explores a simple and efficient baseline for person re-identification (ReID). Person re-identification (ReID) with deep neural networks has made progress and achieved high performance in recent years. However, many state-of-the-arts methods design complex network structure and concatenate multi-branch features. In the literature, some effective training tricks are briefly appeared in several papers or source codes. This paper will collect and evaluate these effective training tricks in person ReID. By combining these tricks together, the model achieves 94.5% rank-1 and 85.9% mAP on Market1501 with only using global features. Our codes and models are available in Github. 1
Longer Photoperiods with Adaptive Lighting Control Can Improve Growth of Greenhouse-grown ‘Little Gem’ Lettuce (Lactuca sativa)

Supplemental lighting can improve the growth of greenhouse crops, but the electricity required for supplemental lighting can be a significant expense for greenhouse growers. Lighting control strategies that use the dimmability of light-emitting diodes (LEDs) have the potential to decrease this cost. In our experiments, we tested the hypothesis that providing ‘Little Gem’ lettuce (Lactuca sativa) plants with the same daily amount of light, spread out over a longer photoperiod and at lower average photosynthetic photon flux densities (PPFDs), would improve growth because light is used more efficiently to drive photosynthesis at lower PPFDs. We conducted two greenhouse experiments wherein supplemental light was provided to reach a minimum daily light integral (DLI) of 17 mol·m−2·d−1 with a 12, 15, 18, or 21-hour photoperiod using adaptive lighting control of LED lights. As the photoperiod for supplemental lighting was increased and supplemental light was provided at lower average PPFDs, plant dry weight increased. Conversion efficiency, the estimated increase in dry weight per Joule expended on supplemental lighting, increased as the photoperiod was extended from 12 to 21 hours. Leaf size and chlorophyll content index increased with longer photoperiods. The number of plants with symptoms of tipburn, including apical and marginal necrosis, also increased as the photoperiod was extended. These results demonstrate that adaptive lighting control can be used to increase the growth of ‘Little Gem’ lettuce and the energy use efficiency of supplemental lighting by providing supplemental light at relatively low PPFDs.
Pilonidal disease specimens of 905 patients revealed no malignancy, however we still insist on histopathological examination

Aim: Pilonidal disease presents with acute abscess, sinuses, pits and scarring in the sacrococcygeal region. Surgical intervention is one of the treatment options of pilonidal disease. However, it has been a matter of debate, whether histological analysis of surgically resected pilonidal disease specimens would be necessary. Material and Methods: Medical records of the patients with pilonidal disease who underwent either primary excision and closure or modified Limberg flap surgery were reviewed retrospectively. The results of the histopathological examination of the pilonidal disease specimens were evaluated. Results: This study included 905 patients (686 male and 219 female) with pilonidal disease who were treated with surgical intervention. The mean age of the patients was 23.96±7.5 years. All surgically excised pilonidal disease specimens of the patients were histopathologically evaluated in order to rule out malignancy. No malignancy was detected. Conclusion: We conducted a Pubmed search with the term “pilonidal” between January 2000 and March 2019. We identified 91 patients with malignant degeneration arising on pilonidal disease in the English medical literature. The most common pilonidal disease associated malignancy was squamous cell carcinoma. Even it is rare, malignancy may accompany pilonidal disease. Therefore, even we have not encountered any malignancy in 905 patients with pilonidal disease, we still insist on histopathological examination of all surgically resected pilonidal disease specimens in order to rule out malignancy.