Miracle-dz/UniFAR-FTUs huggingface dataset:
N-Formyl Methionine Peptide-Mediated Neutrophil Activation in Systemic Sclerosis

Exaggerated neutrophil activation and formation of neutrophil extracellular traps (NETs) are reported in systemic sclerosis (SSc) but its involvement in SSc pathogenesis is not clear. In the present study we assessed markers of neutrophil activation and NET formation in SSc patients in relation to markers of inflammation and disease phenotype. Factors promoting neutrophil activation in SSc remain largely unknown. Among the neutrophil activating factors, mitochondrial-derived N-formyl methionine (fMet) has been reported in several autoinflammatory conditions. The aim of the current study is to assess whether SSc patients have elevated levels of fMet and the role of fMet in neutrophil-mediated inflammation on SSc pathogenesis. Markers of neutrophil activation (calprotectin, NETs) and levels of fMet were analyzed in plasma from two SSc cohorts (n=80 and n=20, respectively) using ELISA. Neutrophil activation assays were performed in presence or absence of formyl peptide receptor 1 (FPR1) inhibitor cyclosporin H. Elevated levels of calprotectin and NETs were observed in SSc patients as compared to healthy controls (p<0.0001) associating with SSc clinical disease characteristics. Further, SSc patients had elevated levels of circulating fMet as compared to healthy controls (p<0.0001). Consistent with a role for fMet-mediated neutrophil activation, fMet levels correlated with levels of calprotectin and NETs (r=0.34, p=0.002; r=0.29, p<0.01 respectively). Additionally, plasma samples from SSc patients with high levels of fMet induced de novo neutrophil activation through FPR1-dependent mechanisms. Our data for the first time implicates an important role for the mitochondrial component fMet in promoting neutrophil-mediated inflammation in SSc.
Correlation of Childhood Psychological Abuse and Neglect With Mental Health in Chinese College Students During the COVID-19 Pandemic

Experience of childhood maltreatment is a major factor affecting adult mental health. The purpose of this study was to understand the association of childhood psychological abuse and neglect with mental health in college students during the COVID-19 pandemic. An online questionnaire survey was conducted from February 21 to March 12, 2020. The participants were 200 students at a university of physical education in Shaanxi Province, China. Participants completed the Child Psychological Abuse and Neglect Scale and the Mental Health Self-Report Questionnaire. Regarding childhood maltreatment experience, 52.5% of respondents screened positive for childhood psychological abuse, 55.8% for psychological neglect, and 43.6% for both. Moreover, 37.6% of participants screened positive for psychological health problems during the pandemic. Childhood psychological abuse and neglect were positively associated with mental health problems during the COVID-19 pandemic. A regression analysis revealed that the reproving dimension of psychological abuse was a risk factor for mental health problems in college students during the COVID-19 pandemic.
Genomic Effects Associated With Response to Placebo Treatment in a Randomized Trial of Irritable Bowel Syndrome

Background and Aims: Irritable bowel syndrome (IBS), a functional pain disorder of gut-brain interactions, is characterized by a high placebo response in randomized clinical trials (RCTs). Catechol-O-methyltransferase (COMT) rs4680, which encodes high-activity (val) or low-activity (met) enzyme variants, was previously associated with placebo response to sham-acupuncture in an IBS RCT. Examining COMT effects and identifying novel genomic factors that influence response to placebo pills is critical to identifying underlying mechanisms and predicting and managing placebos in RCTs. Methods: Participants with IBS (N = 188) were randomized to three placebo-related interventions, namely, double-blind placebo (DBP), open-label placebo (OLP), or simply trial enrollment without placebo treatment [no placebo (i.e., no pill) treatment control (NPC)], for 6 weeks. COMT rs4680, gene-set, and genome-wide suggestive (p < 10−5) loci effects on irritable bowel symptom severity score (IBS-SSS) across all participants were examined. Results: Participants with IBS homozygous for rs4680 met (met/met) had the greatest improvement across all arms, with significantly greater improvement compared to val/val in DBP (beta (SE), −89.4 (42.3); p = 0.04). Twelve genome-wide suggestive loci formed a gene regulatory network highly connected to EGR1, a transcription factor involved in placebo-related processes of learning, memory, and response to stress and reward. EGR1 gene expression in peripheral blood mononuclear cells (PBMC) was significantly reduced at the endpoint across all treatment arms (log fold-change, −0.15; p = 0.02). Gene-set enrichment analysis returned three genome-wide significant ontology terms (GO:0032968, GO:0070934, and GO:0070937) linked to transcription regulation and GO:0003918 associated with DNA topoisomerase regulation. Conclusion: These results suggest common molecular mechanisms in response to varying forms of placebo that may inform personalized IBS treatment and placebo response prediction. Clinical Trial Registration: ClinicalTrials.gov, Identifier: NCT0280224.
Quantifying Mesophotic Fish Assemblages of Hawai‘i’s Au‘au Channel: Associations With Benthic Habitats and Depth

Mesophotic reefs (30–150 m) occur in the tropics and subtropics at depths beyond most scientific diving, thereby making conventional surveys challenging. Towed cameras, submersibles, and mixed-gas divers were used to survey the mesophotic reef fish assemblages and benthic substrates of the Au‘au Channel, between the Hawaiian Islands of Maui and Lāna‘i. Non-parametric multivariate analysis: Non-metric Multidimensional Scaling (NMDS), Hierarchical Cluster Analysis (HCA), Multi-Response Permutation Procedure (MRPP), and Indicator Species Analysis (ISA) were used to determine the association of mesophotic reef fish species with benthic substrates and depth. Between 53 and 115-m depths, 82 species and 10 genera of fish were observed together with 10 types of benthic substrate. Eight species of fish (Apolemichthys arcuatus, Centropyge potteri, Chaetodon kleinii, Chromis leucura, Chromis verater, Forcipiger sp., Naso hexacanthus, and Parupeneus multifasciatus) were positively associated with increasing depth, Leptoseris sp. coral cover, and hard-bottom cover, and one species (Oxycheilinus bimaculatus) of fish was positively associated with increasing Halimeda sp. algae cover. Fish assemblages associated with rubble were not significantly different from those associated with sand, Montipora coral beds and Leptoseris coral beds, but were distinct from fish assemblages associated with hard bottom. The patterns in the data suggested two depth assemblages, one “upper mesophotic” between 53 and 95 m and the other deeper, possibly part of a “lower mesophotic” assemblage between 96 and 115 m at the edge of the rariphotic and bottomfish complex.
Case Report: Sustained Efficacy of Lumasiran at 18 Months in Primary Hyperoxaluria Type 1

Background: Primary hyperoxaluria type 1 (PH1) is a rare genetic disease caused by hepatic overproduction of oxalate, ultimately responsible for kidney stones, kidney failure and systemic oxalosis. Lumasiran, is a liver-directed RNA interference therapeutic agent. It has been shown to reduce hepatic oxalate production by targeting glycolate oxidase, and to dramatically reduce oxalate excretion. Care Report: We present the case of a teenager patient affected by PH1, who entered in the lumasiran compassionate use program. The patient had a rapid and sustained decrease in urinary oxalate/creatinine ratio, with a mean reduction after lumasiran administration of about 70%. During the 18 months long follow-up, urinary oxalate remained low, reaching nearly normal values. Plasma oxalate also decreased dramatically. Normal levels were reached immediately after the first dose and remained consistently low thereafter. During the same follow-up period, eGFR remained stable at about 60 ml/min/1.73 m2, but no new kidney stones were observed. Existing kidney stones did not increase in size. The patient did not suffer renal colic events and did not require further urological interventions. Conclusion: In our severely affected PH1 patient, lumasiran proved to be very effective in rapidly and consistently reducing plasma oxalate and urinary excretion to normal and near-normal levels, respectively. In the 18 months long follow-up post-lumasiran, the eGFR remained stable and the patient showed clinical improvements. As far as we know, this report covers the longest observation period after initiation of this novel RNAi therapy.
Characteristics of Dysregulated Proinflammatory Cytokines and Cognitive Dysfunction in Late-Life Depression and Amnestic Mild Cognitive Impairment

Background Late-life depression (LLD) and amnestic mild cognitive impairment (aMCI) are two different diseases associated with a high risk of developing Alzheimer’s disease (AD). Both diseases are accompanied by dysregulation of inflammation. However, the differences and similarities of peripheral inflammatory parameters in these two diseases are not well understood. Methods We used Luminex assays to measure 29 cytokines simultaneously in the plasma of two large cohorts of subjects at high risk for AD (23 LLD and 23 aMCI) and 23 normal controls (NCs) in the community. Demographics and lifestyle factors were also collected. Cognitive function was evaluated with the Chinese versions of the Montreal Cognitive Assessment (C-MoCA) and neuropsychological test battery (NTB). Results We observed a remarkably increased level of IL-6 in the plasma and reduced levels of chemokines (CXCL11 and CCL13) in the LLD group compared with the aMCI group. The LLD group also showed lower levels of CXCL16 than the NC group. Furthermore, altered cytokine levels were associated with abnormal results in neuropsychological testing and Geriatric Depression Scale scores in both the LLD and aMCI groups. Notably, combinations of cytokines (IL-6 and CCL13) and two subitems of C-MoCA (orientation and short-term memory) generated the best area under the receiver operating characteristic curve (AUROC = 0.974). Conclusion A novel model based on proinflammatory cytokines and brief screening tests performs with fair accuracy in the discrimination between LLD and aMCI. These findings will give clues to provide new therapeutic targets for interventions or markers for two diseases with similar predementia syndromes.
Assessment of Abrasion-Induced Visual Defects in Twin Screw Wet Granulation Using Wall Friction Measurements

Starting point of the presented study were abrasion effects occurring during a twin screw wet granulation (TSG) process of a new chemical entity (NCE) formulation, resulting in gray spots on the final tablets. Several actions and systematic changes of equipment and process parameter settings of TSG process were conducted which reduced the visual defect rate of the tablets, i.e., gray spots on the surface, below the specification limit. To understand the rationale and mechanism behind these improvements, correlations of defect rates and wall friction measurements using a Schulze ring shear tester were evaluated. To check the suitability of the method, a broad range of wall materials as well as powder formulations at various moisture levels were investigated with regard to their wall friction angle. As differences in wall friction angle could be detected, further experiments were conducted using wall material samples made out of different screw materials for TSG. Evaluation of these screw wall material samples gave first hints, which screw materials should be preferred in regard of friction for TSG process. In the finally presented case study, wall friction measurements were performed using the above mentioned NCE formulation with known abrasion issues at TSG processing. The results confirmed that changes which led to a reduced visual defect rate of tablets correlated with a decreased wall friction angle. The results suggest wall friction measurements as a potent tool for equipment selection and establishment of a suitable process window prior to conducting TSG experiments. Graphical abstract
Andrei AnAtolyevich rudenko1, yury AnAtolyevich vAtnikov2, dAnA AleksAndrovnA korkots1, evgeny vlAdimirovich kulikov2, vlAdimir Petrovich Avdotin2, elenA AnAtolyevnA Piven2, vAlentinA ivAnovnA semenovA2, AnnA mikhAilovnA orlovA2, mArinA ivAnovnA shoPinskAyA2, nikolAy vlAdimirovich sAkhno3, nAtAliA i

| This article discusses the issues of changes in clinical, laboratory and instrumental parameters in black-andwhite cows with increased body condition. The aim of the study is to establish the relationship between the increased fatness in black-and-white cows and clinical, tonometric, electrocardiographic, echocardiographic, biochemical parameters. The studies were carried out on clinically healthy black-and-white cows during the dry period 60 days before calving. All animals had one completed lactation. The experimental and control groups included cows with a milk yield for the previous lactation> 7500 kg, with a body condition score of> 4.25 points. The control group included clinically healthy cows with a body condition score of 3.0–3.5 points. Clinical, electrocardiographic, echocardiographic, and biochemical parameters were assessed. Increased body condition in black-and-white dairy cows leads to a significant increase in heart rate, systolic, diastolic and mean arterial pressure. In obese black-and-white cows, a significant increase in serum activity of alanine aminotransferase, lactate dehydrogenase and alkaline phosphatase. In black-and-white cows, with an increase in body condition, the cardiovascular system becomes more active, a tendency to the development of arterial hypertension, hepatopathy, and oxidative stress. Control of the body condition score, clinical, electrocardiographic, echocardiographic and biochemical parameters in dairy cows helps to prevent metabolic pathologies.
The Donnelly Ridge Site and the Definition of an Early Core and Blade Complex in Central Alaska

Abstract Excavations carried out at the site of Donnelly Ridge in central Alaska have led to the delineation of an early core and blade culture which includes the Campus site and two sites previously excavated on the Teklanika River to the west. Sites of the Denali complex are linked by distinctive microblade cores, core tablets and microblades derived from the latter, large blades, biconvex bifacial knives, certain end-scraper forms, a distinctive burin type, and other traits. The clearest affiliations of the Denali complex are with a series of late Upper Palaeolithic sites west of Lake Baikal, but relationships may be seen with sites in Hokkaido and Kamchatka as well. The bearers of this culture probably entered Alaska prior to the final submergence of the Bering land bridge.
The Effect of Daily Fluctuation of Abusive Supervision over Employees Positive and Negative Emotions, and Recovery Experience

Abstract Abusive supervision impacts employees’ emotions negatively and creates feelings of shame and fear. But it remains unclear how daily employees’ positive and negative emotions are affected and if they can recover. Applying the affective event theory and job demands-resources model we hypothesized that daily abusive supervision influences employees’ positive and negative emotions fluctuation over the day, recovery after work, and employee emotions the next morning. Two daily surveys were answered by 52 Mexican employees for ten days providing 347 registers in the morning and 255 in the afternoon. Hierarchical linear modeling shows alteration of positive and negative emotions in the afternoon and next day, and a positive effect over recovery in relaxation, mastery and control restoring positive emotions. However, negative emotions cannot be recovered for the following day. Additionally, we found effects of predictive variables, as the days of the week go by, positive emotions in the afternoon and negative emotions in the morning decrease. Gender shows for men a more negative effect on positive emotions in the afternoon, next morning and on mastery-recovery. Marital status revealed effect over married individuals incrementing the four recovery dimensions, increasing positive emotions, and reducing negative emotions in the afternoon and next morning. Tenure has an effect over abusive supervision, the longer employees in the company, more likely they suffer abusive supervision. We show how employees restore positive emotions after daily recovery and that negative emotions cannot be recovered for the following day; revealing how abusive managers cause emotional damage to employees every day.
Modeling and System Identification of the Braking System of Urban Rail Vehicles

The braking model of the train is crucial for design of ATO control law for train stop.In this paper,we propose a braking model and a method for identifying its parameters after reviewing the composition,characteristics and interface of the braking system of the urban rail train.The model is validated with data from field experiments.Its applicability for the control purpose has been demonstrated by the performance of an automatic stopping controller designed on the basis of the proposed braking model.
Simulation Research on Relation Between Underwater Explosive Parameters and Water Pressure Under a Typical Charge

When a charge explodes in water,different water pressure exerts different influences on the explosive parameters.Using the finite element analysis software ANSYS/LS-DYNA,a simulation model of a typical charge explosion under different water pressure is established.The blast wave pressure at different points under different water pressure is calculated,and the blast wave pressure changing with water pressure is analyzed.The basic law of the influence of water depth on blast wave pressure is concluded.This research will be valuable to these fields,such as the assessment of warhead lethality of underwater weapons,and the design of fuze range,etc.
SJOVS, December 2020, Vol. 13, No. 2

Uncorrected vision anomalies may cause headaches and may affect reading and academic performance. The purpose of this study was to quantify the frequency of vision anomalies, frequency of eye examinations, and use of corrective eye wear in adolescents in Norway, and to explore whether such vision anomalies affect reading test results or frequency of headaches. A cross-sectional study was performed in 436 adolescents (42.0% males) aged 16–19 years living in South-East Norway. Cycloplegic autorefraction, habitual stereoacuity, and habitual monocular amplitudes of accommodation were measured, and all participants reported the frequency of eye examinations, the use of spectacles and/or contact lens wear, and the frequency of headaches. Reading comprehension and decoding skills were evaluated for a subgroup of the participants (189 participants, 34.4%males) by their performance in national reading tests. Vision anomalies were defined as having refractive errors, poor habitual stereoacuity, or poor habitual amplitude of accommodation in at least one eye. Overall, 44.0% were classified as having a refractive error, and a total of 61.9% were measured to have vision anomalies. More frequent headaches were associated with poor habitual amplitude of accommodation when adjusted for sex (p=0.04). The frequency of poor reading comprehension was higher in the group of adolescents with vision anomalies (n=109, 31.2%) compared with those with no vision anomalies (n=80, 18.8%; p=0.05). Of those with vision anomalies, 33.5% had never had an eye examination, and 63.9% reported not wearing a correction. In Norway, there is no mandatory vision screening after 4 years of age. The results here show that a nation-wide programme of regular eye examinations and proper treatment of vision anomalies for all children and adolescents in Norway should be considered. Identifying and treating children with common eye problems in primary and secondary school will improve educational attainment and increase each child’s chances of succeeding in further education.
Uniform Boundedness and Uniform Ultimate Boundedness for Functional Differential Equations

$x(t, t_{0}, ¥phi)$ with $ x_{t_{¥mathrm{O}}}=¥phi$ of the initial value problem for (1) which depends continuously on the initial data. In this paper we study some conditions in connection with uniform boundedness (UB) and uniform ultimate boundedness (UUB). We give the definitions of some properties (called $¥mathrm{U}¥mathrm{B}$ and $¥mathrm{U}¥mathrm{U}¥mathrm{B}$ at a time $t_{0}$ ) that are weaker than $¥mathrm{U}¥mathrm{B}$ and $¥mathrm{U}¥mathrm{U}¥mathrm{B}$ . Then we $/¥mathrm{p}¥mathrm{r}¥mathrm{o}¥mathrm{v}¥mathrm{e}$ theorems for finite and infinite delay equations using Liapunov functionals that ensure these properties. We also give examples to illustrate the connections and differences between the definitions. The importance of this work can be seen by noting that if solutions are $¥mathrm{U}¥mathrm{B}$ and $¥mathrm{U}¥mathrm{U}¥mathrm{B}$ at $t_{0}$ and the right-hand side of the equation is $¥mathrm{T}$-periodic in $t$ , then there is a $¥mathrm{T}$ -periodic solution (see e.g. [1] for the finite and [2] for the infinite delay case). Also, there are several spaces that can be considered in the infinite delay case, He, Huang and Wang [3] show some of them and prove theorems using Liapunov functionals to ensure $¥mathrm{U}¥mathrm{B}$ and
Thunderstorm Project

The thunderstorm was a hazard which had still not been investigated at the end of the war, a hazard that had caused many serious aircraft accidents. No longer could the old admonition to stay out of thunderstorms be strictly followed by commercial or military pilots, whose flights could not be restricted to fair weather so as to avoid the severe turbulence occurring inside most thunderstorms. This led to the ‘Thunderstorm Project’ in the USA in 1946-47 in Florida and Ohio'. Since the hazardous features of a thunderstorm are associated with individual cells, it is important for an understanding of the storm as it affects flight operations, to be aware of the nature of these features and their variation with stages of cell development.
Simulation of Three-phase Voltage Source PWM Rectifier Based on Sliding-mode Control

AC/DC/AC system in which three-phase voltage source PWM rectifier (VSR) is adopted as the front-end rectifier can hardly obtain good dynamic performance and robustness in four-quadrant operation due to the lag of PI regulator and the sensitiveness of its proportional and integral gains to system parameters. Considering the nonlinear characteristic of VSR, a sliding-mode control algorithm based on synchronous rotating reference frame was proposed. The whole system was modeled and simulated in MATLAB/SIMULINK to obtain comparison between sliding-mode and classical PI control. The results show that the sliding-mode control possesses preferable dynamic response compared with PI regulator.