Miracle-dz/UniFAR-FTUs huggingface dataset:
12-(4-Methoxybenzoyl)-2-methylbenzo[f]pyrido[1,2-a]indole-6,11-dione

In the title compound, C25H17NO4, the indolizine fused naphthaquinone unit is approximately planar [r.m. s deviation = 0.0678 Å] and makes a dihedral angle of 57.82 (5)° with the benzene ring of the methoxybenzene group. The naphthoquinone O atoms deviate, in the same sense, from the mean plane of the fused six-membered rings by 0.2001 (14) and 0.0516 (14) Å. In the crystal there is π–π stacking of inversion-related pairs of molecules [interplanar spacing = 3.514 (2) Å].
6β-Hydroxyeremophil-7(11)-en-8β,12-olide

The title eremophilenolide, C15H22O3, is a natural compound isolated from Senecio laetus Edgew. The two cis-fused six-membered rings have chair confomations and the five-membered ring has a planar envelope conformation [maximum deviation = 0.010 (1) Å]. The β-hydroxy group participates in intermolecular O—H⋯O hydrogen bonding, forming molecular chains along the a axis.
Validity of Isokinetic and Isometric Testing modalities for Assessing Short-term Resistance Exercise Strength Gains

Although it is generally accepted that human performance must be assessed in a manner specific to the training, previous studies have violated this principle. In order to determine the validity of evaluating short-term resistance training programs with isometric and isokinetic measures, 23 recreationally active males participated in an 8-week training program. Subjects were randomly divided into barbell squat, hip sled, leg extension, and control groups. Pre- and posttesting of quadriceps strength was performed with a Cybex isokinetic dynamometer. Six angle-specific torques (N.m) were determined at 0 rad-s-1 and 1.05 rad-s-1. Ten RM training loads increased significantly for all groups that trained. Isometric torque values differed significantly from isokinetic torque values at 30, 60, 75, and 90° of leg flexion for all groups. No significant torque increases from pre- to posttest were observed for any group at any limb angle for either isometric or isokinetic testing, or for isokinetic peak torque. This .
Formulation and evaluation of Gel containing Fluconazole-Antifungal Agent

Fluconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral use of fluconazole is not much recommended as it has many side effects. Commercially fluconazole topical gel preparation are not available in the market, thus this formulation is made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. The gel was formulated by changing the polymer ratio. FT-IR study confirmed the purity of drug and revealed no interaction between the drug and excipients. Gel formulations were characterized for drug content, pH determination, viscosity measurement, in vitro diffusion, antifungal activity and skin irritation. Among the five formulations, F1 was selected as the best formulation as its %CDR after 4½ h was 97.846% and release rate of drug from F1 formulation is best fitted to Higuchi model. The viscosity of the F1 formulation was within the limits and F1 formulation did not show any skin irritation. Gel formulation F1 was found to be stable at 30 ±2°C and 65 ± 5 RH. It was found that at 40 ± 2°C and 75 ± 5 RH the gel formulation was not stable and %CDR was decreased. Efficient delivery of drug to skin application was found to be highly beneficial in localizing the drug to desired site in the skin and reduced side effects associated with conventional treatment.
5,15-Bis(4-pentyloxyphenyl)porphyrin

In the title compound, C42H42N4O2, the complete molecule is generated by a crystallographic inversion centre. The porphyrin system exhibits a near planar macrocycle conformation with an average deviation from the least-squares plane of the 24 macrocycle atoms of 0.037 (5) Å. The phenyl ipso C atoms are positioned above and below the porphyrin plane by 0.35 (1) Å and the macrocycle shows evidence of in-plane rectangular elongation with N⋯N separations of 3.032 (5) and 2.803 (5) Å. Two intramolecular N—H⋯N hydrogen bonds occur.
Off-Target Verbosity and Talkativeness in Elderly People

RÉSUMÉ Cette recherche visait à préciser si, d'une part, la verbosité hors-contexte peut être conceptualisée comme un processus distinct des niveaux élevés de verbalisation qu'on rencontre dans des situations sociales de la vie quotidienne et d'autre part, s'il existe une relation entre l'âge et ces deux styles langagiers. Au total, 125 personnes âgées des deux sexes résident dans la communauté ont participé à une entrevue portant sur leur profil de vie et leurs réponses ont été évaluées séparément par deux assistantes de recherche quant à la fréquence et à l'étendue de la verbosité hors-contexte. Les activités quotidiennes, y compris la verbalisation, ont été évalués par les participants eux-mêmes, par un pair du même âge (N = 125) et par un professionel qui connaissait le participant (N = 10). Une analyse factorielle supporte le modèle selon lequel la verbosité hors-contexte et la verbalisation constituent deux facteurs latents passablement indépendants. De plus, l'âge est en corrélation avee la verbosité. Nous avons interprété les résultats en soulignant que la verbosité hors-contexte ne peut pas être expliquée par les mêmes processus qui sont sous-jacents à la verbalisation sociale. Enfin, nous avons traité des mécanismes possibles qui peuvent expliquer la verbosité. ABSTRACT This study examined whether off-target verbosity should be conceptualized as a distinct process from high levels of talkativeness in every day social situations. The relationship of age to these speech styles was also determined. The responses of 125 community-based elderly adults to a life-history interview were independently rated by two research assistants for the frequency and extent of off-target verbosity. The participant's activities in daily life, including talkativeness, were independently rated by the participants themselves, 125 similar-aged peers and 10 professional workers acquainted with the participants. Confirmatory factor analysis supported a model postulating off-target verbosity and talkativeness as two largely independent latent factors. Age was associated with the verbosity factor. The results were interpreted as indicating that off-target verbosity cannot be explained by the same processes that underlie social talkativeness. Possible mechanisms of the verbosity factor were discussed.
1-(Piperidin-1-yl)-9,10-anthraquinone

In the title compound, C19H17NO2, the piperidine ring adopts a chair conformation. The mean planes of the piperidine ring and the anthracene ring system are inclined at a dihedral angle of 38.7 (1)°. In the crystal, adjacent molecules are linked through C—H⋯π and π–π [centroid–centroid distance = 3.782 (1) Å] interactions, forming a layer parallel to the bc plane.
3α-Azido-5-cholestene

The crystal structure of the title compound, C27H45N3, has been determined as part of our investigation into the hydrophobic modification of aminoglycoside antibiotics. The isopropyl group showed disorder for the tertiary carbon (equal occupancies), with high thermal motion for the peripheral atoms of the isopropyl and azide groups also apparent in the structure. The axial disposition of the azide group is consistent with the clean inversion of stereochemistry at C-3 under Mitsunobu conditions.
Dietary and physical activity counseling in high-risk asymptomatic patients with metabolic syndrome - A primary care intervention

Metabolic syndrome (MetSyn) is related to cardiometabolic risk factors that appear to promote the development of atherosclerotic cardiovascular disease and insulin resistance associated with visceral obesity. An important role in MetSyn treatment is played by the lifestyle intervention including diet recommendations and increase in physical activity. The EuroAspire III – Primary Care Arm survey showed a high prevalence of uncontrolled cardiometabolic risk factors among high-risk asymptomatic patients (obesity, inadequate control of blood pressure, lipids and glucose). General practitioners (GP) recommendations in regard to diet and physical activity were suboptimal and patients’ adherence to lifestyle counseling was reduced. The aim of the study was to assess the efficacy of intensive dietary and physical activity recommendations, made by primary care physicians, in order to improve the management of patients with MetSyn compared to usual care. Two hundred and fifty-three patients with metabolic syndrome were randomized to an intensive lifestyle counseling intervention or usual care. All patients were evaluated using anthropometric measurements and questionnaires for dietary habits and daily physical activity at baseline and after 18 months. Each subject in the intervention group (Group I) was offered a total of approximately 90 min intervention contacts in 3 consecutive visits (every 6 months) to GP offices, consisting in lifestyle habits in relation to diet, weight control and physical activity. Beside this, once a month the patients received a follow-up phone from their GP, emphasis was placed on weight loss, decreasing fat intake, portion control and healthier food group selection along with increasing in daily physical activity. Due to ethical reasons the patients in the control group (Group C) received minimal intervention consisting in one page written general information about the importance of healthy lifestyle. At baseline, main characteristics of the intervention group (n = 133) and control (n =120) were not significantly different. After 18 months of intervention, the patients in the Group I significantly reduced fat (p = 0.001), carbohydrate (p = 0.054) and total caloric intake (p = 0.009) and increased physical activity level compared to the controls (p = 0.042). Antropometric parameters significantly decreased in Group I (weight from 83.4±14.5 to 81.8±14.7 kg, p=0.002; waist circumference from 101.1±11.1 to 98.6±11.1 cm, p<0.001; body mass index from 30.3±4.6 to 29.4±4.4 kg/m 2 , p<0.001) and increased in Group C. The primary care intervention applied in our study improved dietary habits and physical activity level, decreased weight and abdominal obesity, with a positive impact on cardiometabolic risk profile of high-risk asymptomatic patients with metabolic syndrome.
2-Phenyl-7-(4-pyridylmethylamino)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5(4H)-one1

In the title compound, C16H13N7O, the 1,2,4-triazolo[1,5-a][1,3,5]triazine heterocyclic system is essentially planar (r.m.s. deviation = 0.0375 Å). The attached benzene ring lies almost in the mean plane of 1,2,4-triazolo[1,5-a][1,3,5]triazine [dihedral angle = 1.36 (23)°], while the pyridine ring is turned out of this plane by the aminomethyl bridge [dihedral angle = 69.22 (9)°]. The amino group H atom is involved in intramolecular hydrogen bonding with a triazole N atom. In the crystal, molecules are connected via C(=O)NH⋯N hydrogen bonds into C(11) chains parallel to [100]. The amino group H atom acts as a hydrogen-bond donor, forming an NH⋯O=C hydrogen bond with the carbonyl O atom, which links the molecules into C(6) chains running along [011] and [01].
1-Vinyl-1H-indole-3-carbaldehyde

In the title compound, C11H9NO, the C and O atoms of the attached carbaldehyde group deviate by just 0.052 (2) and 0.076 (1) Å, respectively, from the mean plane of the indole ring system. In addition to van der Waals forces, the molecular packing is stabilized by C—H⋯O hydrogen bonds, which form a C(7) chain motif, and π–π interactions (centroid–centroid distance 3.637 Å) between the pyrrole and benzene rings of the indole ring system.
1-Ferrocenyl-3-(3-fluoroanilino)propan-1-one

The title ferrocene derivative, [Fe(C5H5)(C14H13FNO)], crystallizes in the same space group with similar unit-cell parameters as the derivatives 3-anilino-1-ferrocenylpropan-1-one [Leka et al. (2012 ▶). Acta Cryst. E68, m229] and 1-ferrocenyl-3-(4-methylanilino)propan-1-one [Leka et al. (2012 ▶). Acta Cryst. E68, m230]. The dihedral angle between the best planes of the benzene ring and the substituted cyclopentadienyl ring is 83.4 (1)°. The presence of the electronegative fluoro substituent in the meta position of the aniline group does not alter the crystal packing compared to the other two derivatives. The molecules are connected into centrosymmetric dimers via N—H⋯O hydrogen bonds. In addition, C—H⋯O and C—H⋯N contacts stabilize the crystal packing.
Educational Research: Competencies for Analysis and Application

PART I INTRODUCTION Chapter 1 Introduction to Educational Research Chapter 2 Selecting and Defining a Research Topic Chapter 3 Reviewing the Literature Chapter 4 Preparing and Evaluating a Research Plan Chapter 5 Selecting a Sample Chapter 6 Selecting Measuring Instruments PART II QUANTITATIVE METHODS Chapter 7 Survey Research Chapter 8 Correlational Research Chapter 9 Causal-Comparative Research Chapter 10 Experimental Research Chapter 11 Single-Subject Experimental Research PART III QUANTITATIVE DATA ANALYSIS Chapter 12 Descriptive Statistics Chapter 13 Inferential Statistics PART IV QUALITATIVE RESEARCH Chapter 14 Qualitative Data Collection Chapter 15 Narrative Research Chapter 16 Ethnographic Research Chapter 17 Case Study Research Chapter 18 Qualitative Research: Data Analysis and Interpretation PART V MIXED METHODS Chapter 19 Mixed Methods Research: Integrating Qualitative and Quantitative Methods PART VI ACTION RESEARCH Chapter 20 Action Research PART VII REPORTING RESEARCH Chapter 21 Preparing a Research Report PART VIII CRITIQUING RESEARCH Chapter 22 Evaluating a Research Report
11H-Dibenzo[b,e]azepine-6-carbonitrile

The title compound, C15H10N2, crystallizes with two independent molecules in the asymmetric unit. The two benzene rings make dihedral angles of 60.32 (2) and 61.35 (3)°. The crystal packing is stabilized by weak π–π stacking interactions [centroid-to-centroid distances = 3.673 (4) and 3.793 (4) Å].
6a-Nitro-6-phenyl-6,6a,6b,7,8,9,10,12a-octahydrospiro[chromeno[3,4-a]indolizine-12,3′-indolin]-2′-one

In the title compound, C28H25N3O4, the central pyrrolidine ring adopts adopts an envelope conformation with the N atom as the flap and the piperidine ring adopts a chair conformation. The pendant pyrrolidine ring is almost planar (r.m.s. deviation = 0.008 Å). An intramolecular C—H⋯O interaction closes an S(6) ring. In the crystal, inversion dimers linked by pairs of N—H⋯O hydrogen bonds generate R 2 2(8) loops.
4-Ethyl-1-(4-methylbenzylidene)thiosemicarbazide

In the title compound, C11H15N3S, an intramolecular N—H⋯N hydrogen bond generates an S(5) ring. In the crystal, inversion dimers linked by pairs of N—H⋯S bonds occur, generating an R 2 2(8) loop.
{4,4′-Dimethoxy-2,2′-[2,2-dimethylpropane-1,3-diylbis(nitrilomethylidyne)]diphenolato}nickel(II)

In the title complex, [Ni(C21H24N2O4)], the NiII ion has a slightly distorted square-planar geometry, coordinated by the two N and two O atoms of a new tetradentate Schiff base ligand. The dihedral angle between the planes of the two NiNC3O chelate rings is 14.37 (12)°.
Substance Use and Substance Use Disorder by Industry

The National Survey on Drug Use and Health (NSDUH) gathers information about substance use and dependence or abuse. NSDUH defines illicit drugs as marijuana/hashish, cocaine (including crack), inhalants, hallucinogens, heroin, or prescription-type drugs used nonmedically.3 Heavy alcohol use is defined as drinking five or more drinks on the same occasion (i.e., at the same time or within a couple of hours of each other) on 5 or more days in the past 30 days. NSDUH also includes a series of questions to assess symptoms of dependence on or abuse of alcohol or illicit drugs during the past year. These questions are used to classify persons as dependent on or abusing substances based on criteria in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). 4 In this report, dependence on or abuse of alcohol or illicit drugs is referred to as a "substance use disorder. "
OC15 DETECTION OF MATRIX METALLOPROTEINASES IN PRIMARY FROZEN SHOULDERS

In patients with DM (Diabetes Mellitus types I & II), primary frozen shoulders tend to be refractory to all forms of treatment. We collected tissue from the joint capsule of shoulder joints from a variety of patients undergoing surgery as follows: 1. Diabetic Group (DFS): patients with DM who have primary frozen shoulders. 2. Other patients suffering from primary frozen shoulders (FS) 3. Control group (NS). Patients undergoing shoulder surgery that does not involve stiffness of the gleno-humeral joint. Tissue was collected from near to the rotator interval under arthroscopic control. Fibroblast lines were established by serial passage. Thereafter they were exposed to graded concentrations of insulin in vitro for 24 hours and the supernatant retained for assay. Fibroblast lines were analysed from 3 subjects in each group (n=9). Luminex multiplex analysis was performed for MMPs (Matrix Metalloproteinases). TIMP-1 (Tissue Inhibitor of MetalloProteinases) expression. Informed consent was obtained from all subjects. Results: Production of MMP 1,2,3 and 8 by fibroblast lines were distinct between patient groups. MMP-1 production in DFS (mean 716pg/mL) was significantly reduced compared to FS derived patient cells (mean 972pg/mL) (p=0.0138, Mann-Whitney Test). Moreover, striking differences were observed when fibroblasts from DFS patients were compared with those from NS controls (mean 5898pg/mL) (p<0.000). Calculating MMP-1/TIMP-1 ratios revealed significantly lower ratios in DFS (2597), or FS (2860) compared with NS (24,326) (p <0.001). There was no significant difference between ratios of MMP1/TIMP1 in DFS and FS (p=0.977). MMPs 7,9,12 and 13 were not detected in any of the samples. This is the first time these enzymes have been measured and quantified in cells derived from shoulder tissues. Primary Frozen Shoulders produce less MMPs and have a smaller MMP/TIMP ratio than controls. Similarly the diabetic patient derived cells produce less MMP-1, at an even lower level. These deficiencies in MMP1 production may reflect an altered capacity for local tissue re-modelling. MMP modulation may allow therapeutic intervention in the diabetic and frozen shoulder group of patients.
Histopathological study of naturally occurring pathological conditions of uterus affecting reproduction in small ruminants.

The study was conducted to assess the histopathology of genital tract diseases of small ruminants (n=638; sheep 267 and goats 371). Out of the total sheep and goat genitalia examined, 19 (7.11%) and 30 (8.08%), respectively, had uterine abnormalities. Pregnancy was recorded in 11.59 per cent of the abattoir goat genitalia and 7.86 per cent of ewe genitalia. Histopathologically, gravid uterus revealed an increase in the size and number of endometrial glands, sparse stroma and increased cellularity of the surface epithelium. Uterus with pyometra revealed dilated and hyperplastic endothelial glands variably filled with pus. Uterus with hydrometra revealed variably dilated lumen with thin wall or flat in appearance and the variable sized areas of serous fluid accumulation in the endometrial stroma. Uterus with mucometra revealed variably dilated lumen with thin wall and flat in appearance and there was an increase in the number and size of endometrial glands with increased epithelial activity. Uterus with haemorrhages revealed focal areas of haemorrhages in the endometrium or focal areas of hemosiderosis in the endometrial stroma. It was concluded that the natural occurrence of the uterine affections can adversely affect the reproductive performance in sheep and goats.
10a-Hydroxy-9-(4-methoxyphenyl)-3,4,5,6,7,8a,9,10a-octahydro-1H-xanthene-1,8(2H)-dione

In the title compound, C20H22O5, the tetrahydropyran, cyclohexene and cyclohexane rings of the xanthene ring system adopt half-chair, half-boat and chair conformations, respectively. The mean plane of the four roughly planar atoms of the tetrahydropyran ring (r.m.s. deviation = 0.111 Å) forms a dihedral angle of 82.91 (4)° with the methoxybenzene group. In the crystal, molecules are linked via O—H⋯O and C—H⋯O hydrogen bonds into sheets lying parallel to the ac plane. The crystal is further consolidated by weak C—H⋯π interactions.
(E)-1-(3,5-Difluorophenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one

The title compound, C17H14F2O3, is approximately planar, the dihedral angle between the rings being 5.46 (2)°. The H atoms of the central propenone group are trans. The crystal structure is stabilized by intermolecular C—H⋯F hydrogen bonds.
2,6-Bis­[1-(phenyl­imino)­ethyl]­pyridine

The structure of the title compound, C21H19N3 (BIP1), has been determined. The mol­ecule lies on a crystallographic mirror plane. The terminal phenyl groups are rotated 60.2 (2)° from the plane of the ethyl­idene­pyridine system.
Bis{(E)-2-methoxy-6-[(4-methylphenyl)iminomethyl]phenolato}zinc(II)

The title compound, [Zn(C15H14NO2)2], contains a four-coordinate Zn atom located on a twofold rotation axis that exhibits a distorted tetrahedral geometry by two phenolate O atoms and two azomethine N atoms of the Schiff base 2-methoxy-6-[(4-methylphenyl)iminomethyl]phenolate ligands.
(E)-1-(2,4-Dinitrophenyl)-2-[1-(thiophen-2-yl)ethylidene]hydrazine

The molecule of the title compound, C12H10N4O4S, is slightly twisted, with a dihedral angle of 8.23 (9)° between the benzene and thiophene rings. One nitro group is co-planar [O—N—C—C torsion angles = −0.5 (3) and −1.9 (3)°] whereas the other is slightly twisted with respect to the benzene ring [O—N—C—C torsion angles = −5.1 (3) and −5.7 (3)°]. In the crystal, the molecules are linked by weak C—H⋯O interactions into screw chains along the b axis. The molecular conformation is consolidated by an intramolecular N—H⋯O hydrogen bond.
1-[3-(Morpholin-4-yl)propyl]-4-(3-nitrophenyl)spiro[azetidine-3,9′-xanthen]-2-one

The β-lactam (azetidin-2-one) ring of the title compound, C28H27N3O5, is nearly planar [maximum deviation = 0.010 (1) Å] and makes dihedral angles of 75.77 (5), 52.78 (9) and 88.72 (5)°, respectively, with the benzene ring, the least-squares plane formed by the four C atoms of the morpholine ring, which adopts a chair conformation, and the xanthene ring system. In the crystal, C—H⋯O hydrogen-bond contacts connect neighbouring molecules into infinite zigzag chains running parallel to the b axis.
2-Hydroxy-N′-(4-hydroxy-3-nitrobenzylidene)benzohydrazide

The title compound, C14H11N3O5, crystallized with two independent molecules per asymmetric unit. Each molecule assumes an E configuration with respect to the methylidene unit. Intramolecular O—H⋯O and N—H⋯O hydrogen bonds are present in each molecule and they are linked by an O—H⋯O hydrogen bond. The dihedral angles between the mean planes of the two benzene rings are 4.45 (16) and 1.7 (2)° in the two molecules. The crystal structure is stabilized by intermolecular O—H⋯O and N—H⋯O hydrogen bonds.
4-Chloro-N-(2,4-dimethyl­phenyl)­benzamide

Mol­ecules of the title compound, C15H14ClNO, are linked into chains along the c axis by inter­molecular N—H⋯O hydrogen bonds. The xylene and chloro­benzene rings deviate from the amide plane [C(=O)—N] by 77.8 (1) and 29.7 (1)°, respectively.
5-(2-Methoxybenzyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazol-3-ol

In the molecule of the title compound, C17H17N3O3, the triazole ring is oriented at dihedral angles of 88.09 (3) and 83.72 (3)° with respect to the 2-methoxybenzyl and 2-methoxyphenyl rings, respectively. The dihedral angle between the 2-methoxybenzyl and 2-methoxyphenyl rings is 52.95 (3)°. In the crystal structure, intermolecular N—H⋯O hydrogen bonds link the molecules into centrosymmetric dimers. There is a π–π contact between the 2-methoxyphenyl rings [centroid–centroid distance = 3.811 (3) Å].
1-(2-Bromobenzoyl)-6,7-(methylenedioxy)isoquinoline

In the title molecule, C17H10BrNO3, the mean planes of tricycle and bromophenyl fragments form a dihedral angle of 75.5 (1)°. In the crystal, π–π interactions [centroid–centroid distances = 3.556 (2) and 3.898 (8) Å] between the isoquinoline systems link molecules into stacks parallel to the a axis. The crystal packing also exibits weak intermolecular C—H⋯O hydrogen bonds.