Miracle-dz/UniFAR-FTUs huggingface dataset:
Barriers to Enrollment in Post-Stroke Brain Stimulation in a Racially and Ethnically Diverse Population

Background and Purpose Brain stimulation is an adjuvant strategy to promote rehabilitation after stroke. Here, we evaluated the influence of inclusion/exclusion criteria on enrollment in a transcranial direct current stimulation (tDCS) trial in the context of a racially/ethnically diverse acute stroke service at University of Texas Southwestern (UTSW). Methods 3124 (59.7 ± 14.5 years) racially/ethnically diverse (38.4% non-Hispanic white, (W), Hispanic (H) 22%, African American (AA) 33.5%, Asian (A) 2.3%) patients were screened in the acute stroke service at UTSW. Demographics, stroke characteristics, and reasons for exclusion were recorded prospectively. Results 2327 (74.5%) patients had a verified stroke. Only 44 of them (1.9%) were eligible. Causes for exclusion included in order of importance: (1) magnitude of upper extremity (UE) motor impairment, (2) prior strokes (s), (3) hemorrhagic stroke, (4) psychiatric condition or inability to follow instructions, and (5) old age, of these (2) and (4) were more common in AA patients but not in other minorities. 31 of the 44 eligible individuals were enrolled (W 1.68%, H 1.37%, AA .77%, A 3.774%). 90.5% of verified stroke patients did not exhibit contraindications for stimulation. Conclusions 3 main conclusions emerged: (a) The main limitations for inclusion in brain stimulation trials of motor recovery were magnitude of UE motor impairments and stroke lesion characteristics, (b) most stroke patients could be stimulated with tDCS without safety concerns and (c) carefully tailored inclusion criteria could increase diversity in enrollment. Clinical Trial Registration-URL: http://clinicaltrials.gov. Unique identifier: NCT01007136.
The pursuit of happiness: A reinforcement learning perspective on habituation and comparisons

In evaluating our choices, we often suffer from two tragic relativities. First, when our lives change for the better, we rapidly habituate to the higher standard of living. Second, we cannot escape comparing ourselves to various relative standards. Habituation and comparisons can be very disruptive to decision-making and happiness, and till date, it remains a puzzle why they have come to be a part of cognition in the first place. Here, we present computational evidence that suggests that these features might play an important role in promoting adaptive behavior. Using the framework of reinforcement learning, we explore the benefit of employing a reward function that, in addition to the reward provided by the underlying task, also depends on prior expectations and relative comparisons. We find that while agents equipped with this reward function are less happy, they learn faster and significantly outperform standard reward-based agents in a wide range of environments. Specifically, we find that relative comparisons speed up learning by providing an exploration incentive to the agents, and prior expectations serve as a useful aid to comparisons, especially in sparsely-rewarded and non-stationary environments. Our simulations also reveal potential drawbacks of this reward function and show that agents perform sub-optimally when comparisons are left unchecked and when there are too many similar options. Together, our results help explain why we are prone to becoming trapped in a cycle of never-ending wants and desires, and may shed light on psychopathologies such as depression, materialism, and overconsumption.
Experiences and needs of Saudi mothers when a child or adolescent is diagnosed with type 1 diabetes mellitus: a qualitative study

ABSTRACT Aim To explore the experiences of Saudi mothers with children or adolescents who have Type 1 diabetes mellitus at time of diagnosis. Background The Kingdom of Saudi Arabia (KSA) has one of the highest incidence rates of Type 1 diabetes mellitus in children and adolescents in the world. Few studies have considered the most appropriate methods of support for parents in the KSA and none report the experiences of Saudi mothers. Design Phenomenological inquiry. Method Qualitative interviews were conducted with 11 Saudi mothers and data were analysed following Giorgi’s 5-step method. Results The lived experiences of Saudi mothers coalesced around three overarching themes and eight subthemes: 1. In the dark (mother’s instinct, challenges of diagnosis phase, cultural reflections); 2. Empowerment (methods of support, mother’s health and wellbeing); 3. Coping and acceptance (stigma and cultural perceptions, coping strategies, transformation and adaptation). Conclusions Effective interventions delivered in other countries to support mothers may be effective in the KSA. However, the central role that Saudi mothers play in the management of their child’s condition, and the place of Islam in Saudi society, indicate the need for customized methods of support that take into account psychosociocultural needs of both mother and child.
Psychometric properties of the item-reduced version of the comprehensive general parenting questionnaire for caregivers of preschoolers in a Finnish context

Introduction Many instruments for assessing general parenting have been reported as burdensome and are thus seldom used in studies exploring children’s energy balance-related behaviors or weight. This study evaluates the factorial structure of the item-reduced version of the Comprehensive General Parenting Questionnaire (CGPQ), which assesses five constructs of general parenting. Methods The study uses data from two cross-sectional studies: Study 1 in 2014 (n = 173) and Study 2 in 2015–16 (n = 805). Parents of children aged three to six answered the CGPQ; in Study 1 the 69-item version, and in Study 2 the 29-item version. The reduction was based on the results of the confirmatory factor analyses (CFA) in Study 1. In both datasets, internal consistency, as Cronbach’s alphas and intraclass correlations between the items of each construct, was tested. A combined assessment of the CFA and items response theory evaluated the construct validity and the item importance for the 29-item version, and a further the reduced 22-item version. Results In Study 1, the highest Cronbach’s alphas were shown for the five constructs in the 69-item version. A higher intraclass correlation was found between the constructs in the 69- and 29-item versions, than between the 69- and the 22-item version. However, a high concordance was found between the constructs in the 29- and 22-item versions in both Study 1 and in Study 2 (0.76–1.00). Testing the goodness-of-fit of the CFA models revealed that the 22-item model fulfilled all the criteria, showing that it had a better factorial structure than the 29-item model. Standard estimations ranged from 0.20 to 0.76 in the 22-item version. Conclusion The reduced 22- and 29-item versions of the 69-item CGPQ showed good model fit, the 22-item version the better of the two. These short versions can be used to assess general parenting without overburdening the respondents.
Analysis of Fuzzy Logic Models

Of course, Kolmogorov stated probability and statistics on a new and very effective foundation set theory. For the first time in the history basic notions of probability theory have been defined precisely but simply. So a random event has been defined as a subset of a space, a random variable as a measurable function and its mean value as an integral. More precisely, abstract Lebesgue integral. It is hopeful to wait some new stimuls from the fuzzy generalization of the classical set theory. The aim of the chapter is a presentation of some results of the type.
Motility of the Ocular Prosthesis in Anophthalmic Patients: Objective and Patient-perceived Findings

ABSTRACT Aim To study the impact of the prosthesis motility on the Quality of Life (QoL) in anophthalmic patients. Methods Cross-sectional, observational study of 100 anophthalmic patients, of whom 64% had an acryl implant, 6% an Allen implant, 1% a hydroxyapatite implant, 4% a dermis fat graft, 16% no implant, and 9% an unknown implant. We quantitatively assessed the motility of the prosthesis with Kestenbaum glasses and the QoL with a validated questionnaire covering five domains: General functional abilities and care, wearing comfort, physical appearance, psychological and social functioning. Associations between measured prosthetic eye motility, patient-perceived motility, and satisfaction were made. Results Motility of the prosthesis was impaired with an average loss of 76%, and correlated with Cosmetic satisfaction (adduction P = .02, abduction P = .008, elevation P = .04) and Social satisfaction (adduction P = .03, abduction P = .003). The patient-perceived motility of the prosthesis correlated with General functioning abilities (horizontal P = .0004, vertical P = .0004), Comfort (horizontal P = .001, vertical P = .003), Cosmetic satisfaction (horizontal P = .0002, vertical P = .0002), Psychological satisfaction (horizontal P = .001, vertical P = .001), and Social satisfaction (horizontal P = .002, vertical P = .003). Conclusions Ocular prosthetic motility has a significant impact on patient-perceived satisfaction and physical appearance, and predicts coping with the prosthetic condition on the psychosocial level. This highlights the need of introducing patient-reported outcome measures in the prosthetic rehabilitation of the anophthalmic patient.
Family Floer cohomology and mirror symmetry

Ideas of Fukaya and Kontsevich-Soibelman suggest that one can use Strominger-Yau-Zaslow's geometric approach to mirror symmetry as a torus duality to construct the mirror of a symplectic manifold equipped with a Lagrangian torus fibration as a moduli space of simple objects of the Fukaya category supported on the fibres. In the absence of singular fibres, the construction of the mirror is explained in this framework, and, given a Lagrangian submanifold, a (twisted) coherent sheaf on the mirror is constructed.
DFNA5 inhibits colorectal cancer proliferation by suppressing the mTORC1/2 signaling pathways via upregulation of DEPTOR

ABSTRACT The human deafness, autosomal dominant 5 gene (DFNA5), a newly discovered executor of pyroptosis, has been strongly implicated in the tumorigenesis of several human cancers. However, an understanding of the functional role of DFNA5 in the development and progression of colorectal cancer (CRC) is limited. In this study, we demonstrated that DFNA5 was downregulated in CRC tissues. Ectopic expression of DFNA5 inhibited tumor cell growth in vitro, retarded tumor formation in vivo, and blocked a cell-cycle transition from the G0/G1 to the S phase, whereas a DFNA5 knockdown promoted cell proliferation. Western blotting showed that the levels of cell cycle-related proteins, including cyclin D1, cyclin E, CDK2, and p21, were accordingly altered upon DFNA5 overexpression or DFNA5 knockdown. Mechanistic studies indicated that DFNA5 exerted its tumor suppressor functions by antagonizing mTORC1/2 signaling via upregulation of DEPTOR. In addition, blockage of mTORC1/2 signaling by Torin-1 abolished the accelerative proliferation by DFNA5 knockdown. In conclusion, these results indicated that DFNA5 inhibits the proliferation and tumor formation of colon cancer cells by suppressing mTORC1/2 signaling.
Seed to seed variation of proteins of the yellow pea (Pisum sativum L.)

The existing variation among pea protein isolates’ functionality limits their application in food formulations. The source and extent of variations among yellow pea protein profiles was assessed in 10 single seeds of two varieties with different size and weight. A new approach was developed to analyze proteins of yellow pea combining three analytical methods of size exclusion chromatography (SEC), reverse phase high performance liquid chromatography (RP-HPLC), and microfluidic SDS-PAGE, to achieve the highest separation resolution. A high variation of protein concentration was observed not only between varieties, but also among seeds of the same variety. Vicilin to legumin ratio was between 2.72–4.19, and 1.70–2.22 among the individual seeds of AC Agassiz and CDC Saffron varieties, respectively. V/L ratio was significantly different among the individual seeds for both varieties. The amount of some protein fractions/subunits were correlated with seeds’ size and weight for AC Agassiz, while such correlations were not observed for CDC Saffron.
Overcoming Black Americans’ Psychological and Cognitive Barriers to Clinical Trial Participation: Effects of News Framing and Exemplars

ABSTRACT This study examines how news features (framing and the use of exemplars) can help overcome two common barriers (psychological and cognitive) impeding Black American participation in clinical trials. In an online experiment, Black participants (N = 390) viewed social media news posts varying in framing (focus on psychological vs. cognitive barriers) and use of an exemplar (present vs. absent and White vs. Black) and then responded to outcome measures including perceived message effectiveness, message attitudes, and intention to participate in clinical trials. The findings illustrate that including a racially matched (i.e. Black) exemplar improves attitudes toward clinical trial messages. Most notably, featuring a race-matched exemplar increases intention to participate in a trial when the messages discuss psychological barriers. These findings enhance our understanding of how messages can be better designed to increase Black American participation in clinical trials, thereby contributing to reducing health inequities and improving health outcomes.
Fermi surface and electronic homogeneity of the overdoped cuprate superconductor Tl2Ba2CuO6+\delta as revealed by quantum oscillations

We report an angular quantum oscillation study of Tl_2Ba_2CuO_{6+delta} for two different doping levels (Tc = 10K and 26 K) and determine the Fermi surface size and topology in considerable detail. Our results show that Fermi liquid behavior is not confined to the edge of the superconducting dome and is robust up to at least T_c^{max}/3.5. Superconductivity is found to survive up to a larger doping p_c = 0.31 than in La_{2-x}Sr_xCuO_4. Our data imply that electronic inhomogeneity does not play a significant role in the loss of superconductivity and superfluid density in overdoped cuprates, and point towards a purely magnetic or electronic pairing mechanism
Replication: Deep Learning for Detecting Cyberbullying Across Multiple Social Media Platforms

Cyberbullying is a type of bullying that is done through digital media and platforms. It includes sending, posting, or sharing negative, harmful, false, or mean content about someone else. In recent studies, deep learning based models have been used in the detection of cyberbullying incidents on social media platrforms, claiming that they can overcome the limitations of traditional machine learning models, and improve the performance. Our main focus is to investigate the findings of a recent literature in this regard by re-producing the methods and architectures used and then validating their findings using the same datasets, namely human-labelled data on "attacks" in Wikipedia Talks pages, racism and sexism in Twitter interactions, and bullying in Formspring posts. To achieve this we are recreating the statement and checking the claims made in the previous paper. This way we adapt our code, rather than just trying the old code to work. Unfortunately, our results do not accept the main clame made in the previous paper. Only the Formspring dataset shows a clear performance difference between the best Deep Learning model and the best traditional ML model.
Factors related to cadre perceptions and behavior in promoting family planning at community health centers based on the Health Promotion Model (HPM)

Introduction: The coverage of family planning in Indonesia has yet been evenly distributed. The government, the private sector, and the community, including health cadres, have an important role to succeed the family planning program. Through cadres, family planning promotion can reach a wider community. Aims: This study aims to explain the relationship between cadre perceptions and their behavior in promoting family planning based on the Health Promotion Model (HPM). Method: The research design used was correlational with a cross-sectional approach. Participants were 200 cadres from the community health centers obtained by cluster sampling techniques. Participants filled the perception questionnaires and the data was analyzed using Spearman's rho test (α=0.05). Results: The analysis showed that there were correlations between perceived benefits (r = 0.490), perceived barriers (r = 0.148), perceived self-efficacy (r = 0.420), activity-related effects (r = 0.165), and situational influence (r = 0.481) with cadres’ behavior in promoting family planning at the community health centers (p<α<0.05). Conclusions : Positive perceived benefits of action, perceived barriers to action, perceived self-efficacy, activity-related effects, and high situational influence will increase the cadres’ good behavior in promoting family planning to the community. Cadres should enhance their knowledge and ability as well as foster their intention and enthusiasm to support family planning to the community.
Overcoming psychology's methodology

Reworking psychology ’ s methodology is of utmost importance if the discipline is to progress. This paper explores methodological strategies which could help overcome the methodological crisis outlined by Toomela (Culture of Science: Strange History of the Methodological Thinking in Psychology. Integrative Psychological and Behavioral Science , 2007, doi:10.1007/s12124-007-9004-0). First, I describe a classic research program (i.e., Bartlett ’ s experiments on remembering) that exemplifies the virtues of a “ German – Austrian ” approach to psychology. Second, I elaborate upon these insights to investigate other aspects of remembering. Finally, I conclude by outlining a methodological programmatic for future research in psychology that overcomes existing forms of experimentation in a new synthesis. The new methodology borrows from both traditions advancing via rich description of single cases and their qualitative transformation to complex theory capable of explaining all individual cases. research but will falter in developing a solid theory of remembering as a social and constructive process.
Developing wipe sampling strategy guidance for assessing environmental contamination of antineoplastic drugs

Surveillance for environmental contamination of antineoplastic drugs has been recommended by authoritative bodies such as the United States Pharmacopeia and the National Association of Pharmacy Regulatory Authorities. Clear guidance is needed on how to develop sampling strategies that align with surveillance objectives efficiently and effectively. We conducted a series of simulations using previously collected surveillance data from nine cancer treatment centers to evaluate different sampling strategies. We evaluated the impact of sampling 2, 5, 10, or 20 surfaces, at monthly, quarterly, semi-annual, and annual frequencies, while employing either a random or sentinel surface selection strategy to assess contamination by a single antineoplastic drug (AD) or by a panel of three ADs. We applied two different benchmarks: a binary benchmark of above or below the limit of detection and AD-specific hygienic guidance values, based on 90th percentile values as quantitative benchmarks. The use of sentinel surfaces to evaluate a three-drug panel relative to 90th percentile hygienic guidance values (HGVs) resulted in the most efficient and effective surveillance strategy.
Establishing electroporation thresholds for targeted cell specific cardiac ablation in a 2D culture model

Irreversible electroporation has emerged as a new modality to overcome issues associated with other energy sources for cardiac ablation. Strong evidence on the optimal, effective, and selective voltage threshold is lacking for both in vitro and preclinical in vivo studies. The aim of this study is to examine the optimal threshold for selective cell ablation on cardiac associated cell types.
Menopause practice standards

Produced by: British Menopause Society (BMS) Royal College of Obstetricians and Gynaecologists (RCOG) Society for Endocrinology (SfE) Faculty of Sexual and Reproductive Health (FSRH) Faculty of Pharmaceutical Medicine (FPM) Royal Pharmaceutical Society (RPS) TheseMenopause Practice Standards were produced by the British Menopause Society (BMS), Royal College of Obstetricians and Gynaecologists (RCOG), Society for Endocrinology (SfE), Faculty of Sexual and Reproductive Health (FSRH), Faculty of Pharmaceutical Medicine (FPM) and the Royal Pharmaceutical Society (RPS). The aim of the standards is to provide evidence-based recommendations and guidance on best menopause practice to support healthcare practitioners delivering menopause care in line with current national and international guidelines and recommendations.
Bioactive potentiality of secondary metabolites from endophytic bacteria against SARS-COV-2: An in-silico approach

Five endophytic bacterial isolates were studied to identify morphologically and biochemically, according to established protocols and further confirmed by 16S rDNA Sanger sequencing, as Priestia megaterium, Staphylococcus caprae, Neobacillus drentensis, Micrococcus yunnanensis, and Sphingomonas paucimobiliz, which were then tested for phytohormone, ammonia, and hydrolytic enzyme production. Antioxidant compounds total phenolic content (TPC), and total flavonoid content (TFC) were assessed by using bacterial crude extracts obtained from 24-hour shake-flask culture. Phylogenetic tree analysis of those identified isolates shared sequence similarities with the members of Bacillus, Micrococcus, Staphylococcus, and Pseudomonas species, and after GenBank submission, accession numbers for the nucleotide sequences were found to be MW494406, MW494408, MW494401, MW494402, and MZ021340, respectively. In silico analysis was performed to identify their bioactive genes and compounds in the context of bioactive secondary metabolite production with medicinal value, where nine significant bioactive compounds according to six different types of bioactive secondary metabolites were identified, and their structures, gene associations, and protein-protein networks were analyzed by different computational tools and servers, which were reported earlier with their antimicrobial, anti-infective, antioxidant, and anti-cancer capabilities. These compounds were then docked to the 3-chymotrypsin-like protease (3CLpro) of the novel SARS-COV-2. Docking scores were then compared with 3CLpro reference inhibitor (lopinavir), and docked compounds were further subjected to ADMET and drug-likeness analyses. Ligand-protein interactions showed that two compounds (microansamycin and aureusimine) interacted favorably with coronavirus 3CLpro. Besides, in silico analysis, we also performed NMR for metabolite detection whereas three metabolites (microansamycin, aureusimine, and stenothricin) were confirmed from the 1H NMR profiles. As a consequence, the metabolites found from NMR data aligned with our in-silico analysis that carries a significant outcome of this research. Finally, Endophytic bacteria collected from medicinal plants can provide new leading bioactive compounds against target proteins of SARS-COV-2, which could be an effective approach to accelerate drug innovation and development.