Miracle-dz/UniFAR-FTUs huggingface dataset:
Observational study of pimecrolimus 1% cream for prevention of transcutaneous sensitization in children with atopic dermatitis during their first year of life

Introduction Epidermal barrier dysfunction in children with atopic dermatitis can cause transcutaneous sensitization to allergens and allergic diseases. We evaluated the effectiveness of an early-intervention algorithm for atopic dermatitis treatment, utilizing pimecrolimus for long-term maintenance therapy, in reducing transcutaneous sensitization in infants. Method This was a single-center cohort observational study that enrolled children aged 1-4 months with family history of allergic diseases, moderate-to-severe atopic dermatitis, and sensitization to ≥ 1 of the investigated allergens. Patients who sought medical attention at atopic dermatitis onset (within 10 days) were group 1 “baseline therapy with topical glucocorticoids with subsequent transition to pimecrolimus as maintenance therapy”; patients who sought medical attention later were group 2 “baseline and maintenance therapy with topical glucocorticoids, without subsequent use of pimecrolimus”. Sensitization class and level of allergen-specific immunoglobulin E were determined at baseline, and 6 and 12 months of age. Atopic dermatitis severity was evaluated using the Eczema Area and Severity Index score at baseline and 6, 9 and 12 months of age. Results Fifty-six and 52 patients were enrolled in groups 1 and 2, respectively. Compared with group 2, group 1 demonstrated a lower level of sensitization to cow's milk protein, egg white and house dust mite allergen at 6 and 12 months of age, and a more pronounced decrease in atopic dermatitis severity at 6, 9 and 12 months of age. No adverse events occurred. Discussion The pimecrolimus-containing algorithm was effective in treating atopic dermatitis and prophylaxis of early forms of allergic diseases in infants. Trial registration https://clinicaltrials.gov/ NCT04900948, retrospectively registered, 25 May 2021.
The blood cells count in leukocyte and leukocyte-poor platelet-concentrated plasma in patients with musculoskeletal disorders

The cellular composition significantly affects the properties of platelet concentrates. In particular, leukocyte platelet concentrates due to the increased number of monocytes and granulocytes have increased levels of proinflammatory cytokines, which contribute to the destruction of extracellular matrix, reduce synthesis of its components and enhance inflammation in tissues. The purpose. To determine the blood cells number in leukocyte (L-PCP) or leukocyte-poor platelet-concentrated plasma (LP-PCP) and compare it with whole venous blood, plasma and platelet-poor plasma. Materials and methods. 20 L-PCP and 21 LP-PCP samples were obtained by double centrifugation from the venous blood of 30 donors aged 26 to 78 with local pathology of the musculoskeletal system. In the first stage, plasma was isolated after the separation of whole blood, and in the second stage, platelets were concentrated in a small volume of platelet-poor plasma. The number of blood cells in the test samples was determined by hematology analyzer. Results. When comparing the platelet count in L-PCP and LP-PCP, no significant difference was found in platelet number (2803.2 ± 933.8·10 and 2260 ± 943.9·10 cells/mL, respectively). The efficiency of platelet concentration from the initial volume of whole blood for the methods of obtaining LP-PCP and L-PCP did not differ significantly and was 76.5 ± 23.4 % and 83 ± 24.9 %, respectively. Platelet count in L-PCP was 8, 13 and 239 times higher than in plasma, whole blood and platelet-poor plasma, respectively. The number of platelets in LP-PCP while exceeded their count in the same samples by 8, 11 and 194 times, respectively. The leukocyte number in leukocytepoor and leukocyte plasma with platelet concentrate was 2.5 ± 1.2·10 and 5.9 ± 1.8·10 cells/mL, respectively. However, their number in LP-PCP was almost 2 times lower than in blood and 5 times www.transplantology. org Cell and Organ Transplantology. 2020 May; Vol. 8, No. 1 higher compared with plasma. The number of leukocytes in L-PCP was 30 % higher than in the blood, and 6 times higher than in plasma. The erythrocyte number was reduced by 99 % in both types of plasma with platelet concentrate compared with their count in whole blood. Conclusions. According to the parameter of platelet isolation from whole blood, the procedures for obtaining leukocyte or leukocyte-poor platelet-concentrated plasma belong to the methods with medium efficiency. The procedure for preparing L-PCP allows to get a product with an increased relative number of leukocytes. It was possible to achieve a significant reduction in erythrocyte count for both studied products.
Architecture of parallel adaptation to freshwater in multiple populations of threespine stickleback

Threespine sticklebacks adapted to freshwater environments all over the Northern Hemisphere. This adaptation involved parallel recruitment of freshwater alleles in clusters of closely linked sites, or divergence islands (DIs). However, it is unclear to what extent the DIs involved in adaptation and the alleles within them coincide between populations adapting to similar environments. Here, we examine 10 freshwater populations of similar ages from the White Sea basin, and study the repeatability of patterns of adaptation in them. Overall, the 65 detected DIs tend to reside in regions of low recombination, underlining the role of reduced recombination in their establishment. Moreover, the DIs are clustered in the genome to the extent that is not explainable by the recombination rate alone, consistent with the divergence hitchhiking model. 21 out of the 65 DIs are universal; i.e., the frequency of freshwater alleles in them is increased in all analyzed populations. Universal DIs tend to have longer core region shared between populations, and the divergence between the marine and the freshwater haplotypes in them is higher, implying that they are older, also consistently with divergence hitchhiking. Within most DIs, the same set of sites distinguished the marine and the freshwater haplotypes in all populations; however, in some of the DIs, the genetic architecture of the freshwater haplotype differed between populations, suggesting that they could have been established by soft selective sweeps.
Attachment, Ego Resilience, Emerging Adulthood, Social Resources, and Well-Being Among Traditional-Aged College Students

To improve conceptualizations of college student mental health, the present study (N = 538) compared predictors of well-being that comprise both well-established counseling theories (e.g., attachment) and newer models specific to the life experience of the millennial generation and Generation Z. Predictors included internal resources (i.e., attachment security, ego resilience), emerging adulthood identification, and social resources (i.e., social support, social media usage). Each variable set predicted significant variance. The emerging adulthood and social media variables accounted for approximately 7% of variance in both psychological well-being and life satisfaction. Identifying emerging adulthood as a time of negativity and instability was the second strongest predictor of psychological well-being, while identifying emerging adulthood as a time of experimentation and possibilities was the second biggest predictor of life satisfaction. Implications for conceptualizing and treating today’s students are discussed.
Environmental chamber studies of atmospheric reactivities of volatile organic compounds. Effects of varying ROG surrogate and NOx. Final report

Environmental chamber experiments were conducted to measure reactivities of 12 representative alkanes, alkenes, aromatics, and oxygenates in irradiations of various reactive organic gas (ROG) surrogate - NOx - air mixtures designed to approximate photochemical smog. The results show that VOCs have a greater range of reactivities with a simpler surrogate than when the more realistic surrogate is used. Reducing NOx reduced reactivities by differing amounts for different VOCs. These results are consistent with model predictions, though the model performed better simulating experiments with the more complex surrogate than the simpler systems, because the latter are more sensitive to differrences among the VOCs. The model predicted that experimental and atmospheric reactivities may correlate under high NOx conditions, but not when NOx is low. Thus the best use of reactivity experiments is evaluating the models which predict atmospheric reactivities.
Maize–soybean intercropping effect on yield productivity, weed control and diversity in northern Ghana

The cereal–legume cropping system is a common practice across the tropical world. However, there are limited quantitative data on the effect of cereal–legume intercropping on weed species diversity. A study was conducted in the Guinea savanna zone of Ghana to evaluate the effect of maize–soybean intercropping on yield productivity and weed species control. The treatments used include three maize maturity types (extra‐early: Abontem, early: Sammaz 27 and medium: Obatanpa) intercropped with soybean at three intraspacing (10, 20 and 30 cm), and their sole crop treatments were laid in a randomized complete block design with three replications. Results showed that the land equivalent ratio (LER) for the intercrops was above 1, indicating better intercrop productivity than the sole crops. An average of 40% land was saved for the intercrops compared with the sole crops. Intercropping Sammaz 27 maize with soybean significantly increased LER by 9% compared to the other types. Intercropping maize with soybean significantly reduced weed biomass at 6 and 9 weeks after planting (WAP) and at harvest relative to the sole maize. The weed biomass at 6 and 9 WAP and harvest increased (p < .05) with increasing soybean intraspacing. The grass and broadleaf weed species count at 6 WAP and harvest from the sole crops were significantly higher than that of the intercrops. The results suggest that intercropping early maize maturity type with soybean at 10 cm intraspacing could be used to increase grain yield, LER and control of grass and broadleaf weeds in a maize‐based cropping system in the Guinea savanna zones of West Africa.
THE VALUATION OF EUROPEAN OPTION UNDER SUBDIFFUSIVE FRACTIONAL BROWNIAN MOTION OF THE SHORT RATE

In this paper, we propose an extension of the Merton model. We apply the subdiffusive mechanism to analyze European option in a fractional Black–Scholes environment, when the short rate follows the subdiffusive fractional Black–Scholes model. We derive a pricing formula for call and put options and discuss the corresponding fractional Black–Scholes equation. We present some features of our model pricing model for the cases of [Formula: see text] and [Formula: see text].
THE EFFECT OF NIMODIPINE ON CALCIUM INTRACELLULAR AND ROS EXPRESSION IN NEURON CULTURE CELL LINE SH-SY5Y INDUCE CHRONIC HIPERGLYCEMIA

Introduction: A frequent microvascular complication of diabetes mellitus were peripheral neuropathies with a prevalence of around 30-50%. Generally, oxidative stress is the key to the pathological process that induces damage to peripheral nerves in sensory neurons thereby increasing the production of reactive oxygen species (ROS) and mitochondrial dysfunction which causes deregulation of calcium ion homeostasis and disrupted calcium signaling. Nimodipine is an L-type Ca2+ inhibitor that reactivates the ATPase pathway, has a neuroprotective effect and can improve the regulation of blood and nerve flow in restoring the adrenergic function of the vasa nervorum. Aim: The purpose of this study was to determine the effect of 0.5µm nimodipine on intracellular calcium and ROS expression in SH-SY5Y cell cultures induces chronic hyperglycemia. Method: Normoglycemic glucose-induced cell culture of neurons 25mM, 50mM hyperglycemia for 6 days and then given nimodipine and without 0.5µM nimodipine. Results: Based on the results of the One-Way ANOVA test, there was a significant difference (p<0.05) in intracellular calcium expression and ROS in cell cultures exposed to chronic hyperglycemia. Nimodipine 0.5µM significantly reduced intracellular calcium expression but did not reduce ROS expression. The Spearman rank correlation test (r=0.5; p>0.05) given nimodipine 0.5µM therapy found a positive correlation, but not significant. Conclusion: Based on this study it can be concluded that the administration of 0.5µM nimodipine can reduce intracellular calcium expression but has not been able to reduce ROS expression in 50mM glucose-induced cell cultures.
Estimation of Supply and Demand Elasticities for Major Crops Produced in Pakistan

Thisarticlestudiesthe supply and demand of major Pakistani crops. We estimatesupply elasticities usinga Nerlovian partialadjustment processanddemand elasticities usingthe Deaton and MuellbauerAlmost Ideal Demand Systems (AIDS). We usesecondary data from various Household IntegratedEconomicSurveysand Agricultural Statistics of Pakistan. Our estimated supplyelasticities with respect to price liebetween 0.1 and 0.5 for all crops. Pulses tend to have higher elasticities than traditional crops such as wheat and rice. Demand elasticities with respect to price tend to beinelastic, with the exception of poultry andfruit which appearto be luxury items. Pulses are income inelastic, implying that consumption may not rise significantly asper capita incomesand thatthe introduction of yield enhancing varietieswill lead to lower prices.
Terpenes as Potential Antimalarial Drugs

A fact which favors the increase in morbidity and mortality of malaria cases in the world is the resistance to chemotherapeutic agents that the parasite presents. Therefore, it is necessary to identify new potential targets specific to the parasite in order to be able to perform a rational planning. One target for the evaluation of potential antimalarial compounds is isoprenoid synthesis, which occurs via the 2-C-methyl-d-erythritol-4-phosphate pathway in Plasmodium falciparum. Several intermediaries and final products of this pathway were identified in the parasite and lead us to the conclusion that it is different from the vertebrate host. In this chapter, we describe the effect of some monoterpenes and sesquiterpenes on Plasmodium falciparum and Plasmodium berghei as potential antimalarial drugs.
Bacterial profiles and phenotypic biomarkers of microbiota isolates in habitat: hazard identification factors

The present work focuses on assessing bacterial profiles of microbiota existing on technological equipment applied in food products manufacturing, objects located inside medical and preventive facilities, and water objects in recreation zones; another goal was to examine phenotypic properties of opportunistic pathogenic bacteria isolates as hazard identification factors within the framework of risk assessment concept. Our research objects were strains of Escherichia, Klebsiella, Enterobacter, Staphylococcus, Pseudomonas, Citrobacter and Serratia families that were detected and extracted due to hygienic monitoring activities performed in 2013–2017. Samples were taken via washing, direct inoculation, membrane filtration, and instrumental aspiration technique. Microbial status was analyzed with cultural and biochemical techniques on nutrient and differential-diagnostic media with subsequent confirmation with polymerase chain reaction (PCR). Phenotypic peculiarities were examined in vitro with conventional biochemical and microbiological techniques in conformity with the requirement fixed in Good Laboratory Practice. We revealed peculiarities of microbial profiles belonging to opportunistic pathogenic microbiota on different objects in habitats. The greatest groups included staphylococci detected in the air inside medical organizations with 1–4 cleanness degree (44 %); Enterobacteriaceae family bacteria, in washes off objects located in manufacturing and medical and prevention facilities (64 % and 69 % accordingly); Pseudomonas family bacteria, in water objects (46 %). 60 (36 %) isolates out of 167 examined ones had modified morphological and tinctorial signs regarding those typical for a family. Most isolates had a set of modified or atypical metabolomic signs such as hemolytic and lecithinase activities, apparent persistent factors, and ability to create biofilms. Opportunistic pathogenic bacteria strains extracted from washes off objects located inside food products manufacturing and medical and preventive facilities were the most poten-tially aggressive. Isolates from the same families extracted from water objects in recreation zones and air inside medical and preventive facilities had less apparent phenotypic properties that characterized their pathogenic potential. Our experimental data provide useful materials for examining a phenomenon related to changes in phenotypic properties; they can be applied during revealing and drawing up a hazard profile and for minimizing uncertainty within the concept of microbiological risk analysis.
SCHOOL CONFLICT MANAGEMENT PROGRAM AS A TOOL TO IMPROVE SCHOOL SOCIAL CLIMATE: LESSONS FOR LITHUANIA

Constructive conflict management in education setting encompasses recognition that conflicts are part of solutions, and usage of conflicts to enhance the quality of school life, teaching and learning. Contrary, by refusing to acknowledge that conflicts are possibility of solutions and by denying their existence schools might contribute to the development of school climate in which both students and teachers feel damaged. The evidence of unskilled conflict resolution processes in Lithuania’s schools has encouraged search of efforts to be taken by administrators and teachers for becoming more skilful in using constructive conflict procedures. The idea of conflict resolution education is discussed in the article. Conflict resolution education programs are that incorporate effective, nonviolent problem-solving concepts into school wide policies and classroom curricula, teach skills that can be used to implement the positive disciplinary procedures, and conduct conflict management skill building (Batton, 2002). Programs addressing conflict resolution are widely used in U.S. schools as they are viewed as effective tools to decrease violence or/and disruptive behaviours in school settings. The aim of the article is to review School Conflict Management Program implemented in the Ohio State (USA) highlighting peculiarities leading to success. The research question is such as: What are the peculiarities of effective CRE curriculum and its’ implementation? There is a considerable evidence that CRE increases students‘ self-control, communication skills, healthy interpersonal/ inner-group relations. However, conflict resolution education is to be addressed not only students, but as well as administrators, teachers, and parents. CRE training and practice are critical to increasing conflict management skills, and implementing a CRE program is an extremely complex process that demands considerable energy and time from adults involved. The Ohio model as an illustration of a good practice might be helpful in defining CRE, its components and issues of implementation, discussing the feasibility (infrastructure, needed support) in a culturally different context.
Examining Individual and Organizational Factors of School Counselor Burnout

Burnout is a statistically significant phenomenon for school counselors, correlated with various individual and organizational factors, which have been studied independently. Therefore, we investigated both individual and organizational factors of burnout conceptualized as a multidimensional phenomenon with 227 school counselors. Multidimensional burnout was measured by the five subscales of the Counselor Burnout Inventory, which included Exhaustion, Incompetence, Negative Work Environment, Devaluing Clients, and Deterioration in Personal Life. Using hierarchal regression analyses, we found individual and organizational factors accounted for 66.6% of the variance explained in Negative Work Environment, 38.3% of the variance explained in Deterioration in Personal Life, 36.7% of the variance explained in Incompetence, 35.1% of the variance explained in Exhaustion, and 14.0% of the variance explained in Devaluing Clients. We discuss implications of the findings for school counselors and supervisors. Identifying the multidimensions of burnout and its correlates, addressing self-care and professional vitality goals, communicating defined school counselor roles, providing mentoring opportunities, and increasing advocacy skills may help alleviate burnout.
The Effect of Organizational Culture on Employee Engagement with Work Ethic (Hard Work) as A Moderating Variable: Case Study on Millennial Generation Employees at PT X

The purpose of this study to determine the effect of organizational culture on employee engagement in millennial generation employees at PT X, with the work ethic variable on the hard work dimension acting as a moderator variable. The sample used in this study was 201 millennial generation employees at PT X. This study used the Employee Engagement Scale (Saks, 2006), the Multidimensional Work Ethics Profile (MWEP) to measure the work ethic (hard work), and Values Survey Module (VSM 2013) from Hofstede (2013) to measure organizational culture. The results showed that organizational culture has a significant influence on employee engagement (R2 = 0.258, Sig. = 0.000). In other words, the organizational culture contributed 25.8% to the employee engagement. When the work ethic variable (hard work) is added as a moderator variable, the coefficient R2 increases to 0.352 or contributes 35.20%. Thus the hypothesis is accepted, meaning that the work ethic (hard work) increases or strengthens the influence of organizational culture on employee attachment to millennial generation employees at PT X.
Application Research of Process Design Analysis based on Digital Technology

With the improvement of people’s aesthetic concept, simple bamboo-rattan knitting technology has been unable to meet the people’s design requirements for fur fabric, people hope that fur products have a sense of fashion, artistry and personalized characteristics. We study the development of bamboo-rattan knitting technology, adopting survey method, literature analysis method for data collection, mining the design methods of bamboo-rattan knitting technology in the field of packaging design. From the perspective of bamboo-rattan packaging, we analyze several common methods, but the designing efficiency is low, and the designing accuracy is not high. In order to further improve efficiency of designing, we introduce the digital technology, which can provide an interactive platform for designers, control the whole design process, monitor the production of design schemes and the effect of design schemes, and this technology can achieve standardized production, improve design accuracy, and adopt CAD, Photoshop and 3Dmax, which can be taken as digital technology platform to realize the simulation analysis of bamboo-rattan packaging design. We take digitalization technology as the main method, and integrate with the existing bamboo-rattan packaging methods, put forward the design process of bamboo-rattan fur knitting technology packaging based on digitalization technology, design the bamboo-rattan fur knitting packaging, therefore, get the design effect of bamboo-rattan packaging based on digitalization technology, and confirm that this method can improve the design efficiency of bamboo-rattan knitting products, but also meet the needs of people for bamboo-rattan fur knitting products.