Miracle-dz/UniFAR-FTUs huggingface dataset:
Shear wave elastography combined with electromyography to assess the effect of botulinum toxin on spastic dystonia following stroke: A pilot study

Background Shear wave elastography (SWE) is a method for carrying out a quantitative assessment of the mechanical properties of soft tissues in terms of stiffness. In stroke survivors, the paretic muscles may develop hypertonia due to both neural-mediated mechanisms and structural alterations with consequent muscular fibrous-fatty remodeling. Methods Fourteen adult patients with spastic dystonia following stroke were recruited. Muscle hypertonia was assessed using the modified Ashworth scale (MAS). Muscle activation was measured by surface electromyography (sEMG) with the selected muscle in shortened (spastic dystonia) and stretched (dynamic stretch reflex) positions. SWE was performed on a selected paretic muscle and on the contralateral non-paretic one to calculate shear wave velocities (SWV) along and across muscular fibers. The modified Heckmatt scale (MHS) pattern was also determined. All evaluations were performed shortly before BoNT-A injections (T0) and one month later (T1). Results All SWV on paretic muscles were higher than contralateral non-paretic ones (p < 0.01). After BoNT-A injection, a significant reduction in MAS (p = 0.0018), spastic dystonia (p = 0.0043), and longitudinal SWE measurements, both in shortened (p = 0.001) and in stretched muscular conditions (p = 0.0029), was observed. No significant changes in SWV on non-paretic muscles were observed. Higher SWV resulted along the direction of muscular fibers vs. across them (p = 0.001). No changes resulted from the MHS evaluations after BoNT-A. There was a positive correlation between MHS scores and SWV values while the muscle was in the shortened position, but not with spastic dystonia recorded by sEMG. Conclusions This is the first study evaluating the effect of BoNT-A on muscle hypertonia following stroke, assessed by both SWE and sEMG. These findings support SWE as a useful method to disclose intrinsic muscular remodeling, independently of the effect of spastic dystonia, in particular, while muscles were assessed in a neutral position. SWE measurements of muscle stiffness cannot tell apart neural-mediated and intrinsic muscle hypertonia. Interestingly, when sEMG activity is very limited, as in spastic muscles kept in a shortened position, SWE can provide a measurement of stiffness due almost completely to intrinsic muscle changes. Alongside sEMG, SWE could aid clinicians in the assessment of responses to treatments.
Smartphone addiction and cross-cultural adjustment among overseas Chinese students: The role of emotion regulation beliefs and strategies

Background Few studies have focused on the cross-cultural adjustment of Chinese students studying in Belarus with the size of this group increasing in recent years. The current study aimed to map the process of cross-cultural adjustment onto various factors including childhood emotional neglect, emotion regulation beliefs, emotional regulation strategies, and smartphone addiction in the international students. Emotional regulation strategy and emotion regulation beliefs could perform as key parts in adapting into overseas life from social learning perspective. Furthermore, smartphone addiction could precipitate a failed adjustment process. Materials and methods A total of 356 Chinese students in Belarus completed a self-administered questionnaire including the Chinese versions of the 12-item general health questionnaire (GHQ-12), sociocultural adaptation scale, mobile phone addiction tendency scale for college students, emotion regulation questionnaire, emotion and regulation beliefs scale, and childhood trauma questionnaire-short form. Correlation analysis, regression analysis and T-tests were used to explore the relationship between the variables. Structural equation modeling was carried out to test the hypotheses for association. Results Emotion regulation beliefs of international students mediated the effect of childhood emotional neglect on cross-cultural adjustment through expression suppression and smartphone addiction. While, in another chain mediation model, childhood emotional neglect affected cross-cultural adjustment only through emotion regulation beliefs and smartphone addiction. Cognitive appraisal independently influenced adjustment through smartphone addiction. Limitations Limitations include its cross-sectional design and self-reported survey methodology. In the future, we can combine experimental manipulations to explore the mechanisms by which various emotion beliefs act on smartphone addiction and cross-cultural adjustment in different situations. Conclusion This study displays the correlation between emotion regulation beliefs to smartphone addiction and cross-cultural adjustment, as well as the harmful effects of childhood emotional neglect; these components should be further addressed in future studies.
Harnessing heterosis and male sterility in soybean [Glycine max (L.) Merrill]: A critical revisit

Soybean is a predominantly self-pollinated crop. It is also one of the important oilseed legumes. Soybean is an excellent crop having industrial, traditional, culinary, feeding, and cultural roles. Genetic diversity in breeding programs is of prime importance as it ensures the success of any breeding by enhancing the outcomes and results of the plants. The phenomenon wherein the progeny exhibits greater biomass (yield) and a faster rate of development and fertility than its parents is referred to as heterosis. As of now, heterosis is mainly limited to the trait of seed yield and is considered the basis for the development of better (superior) varieties. Male sterility (MS) is extensively used for the production of seeds and the improvement of crops coupled with the traditional breeding programs and molecular technology. Therefore, deployment of MS and heterosis in breeding soybean could yield better outcomes. This review aims to focus on two aspects, namely, MS and heterosis in soybean with its scope for crop improvement.
Disaster assessment using computer vision and satellite imagery: Applications in detecting water-related building damages

The increasing frequency and severity of water-related disasters such as floods, tornadoes, hurricanes, and tsunamis in low- and middle-income countries exemplify the uneven effects of global climate change. The vulnerability of high-risk societies to natural disasters has continued to increase. To develop an effective and efficient adaptation strategy, local damage assessments must be timely, exhaustive, and accurate. We propose a novel deep-learning-based solution that uses pairs of pre- and post-disaster satellite images to identify water-related disaster-affected regions. The model extracts features of pre- and post-disaster images and uses the feature difference with them to predict damage in the pair. We demonstrate that the model can successfully identify local destruction using less granular and less complex ground-truth data than those used by previous segmentation models. When tested with various water-related disasters, our detection model reported an accuracy of 85.9% in spotting areas with damaged buildings. It also achieved a reliable performance of 80.3% in out-of-domain settings. Our deep learning-based damage assessment model can help direct resources to areas most vulnerable to climate disasters, reducing their impacts while promoting adaptive capacities for climate-resilient development in the most vulnerable regions.
Molecular and cytogenetic dissection of stripe rust resistance gene Yr83 from rye 6R and generation of resistant germplasm in wheat breeding

Rye 6R-derived stripe rust resistance gene Yr83 in wheat background was physically mapped to fraction length (FL) 0.87-1.00 on the long arm by non-denaturing-fluorescence in situ hybridization (ND-FISH), Oligo-FISH painting and 6R-specific PCR markers.Stripe rust resistance gene Yr83 derived from chromosome 6R of rye (Secale cereale) “Merced” has displayed high resistance to both Australian and Chinese wheat stripe rust isolates. With the aim to physically map Yr83 to a more precise region, new wheat- 6R deletion and translocation lines were produced from derived progenies of the 6R(6D) substitution line. The non-denaturing fluorescence in situ hybridization (ND-FISH) patterns of 6R were established to precisely characterize the variations of 6R in different wheat backgrounds. Comparative ND-FISH analysis localized the breakpoints of 6RL chromosomes relative to Oligo-pSc200 and Oligo-pSc119.2 rich sites in deletion lines. Molecular marker and resistance analyses confirmed that Yr83 is physically located at the fraction length (FL) 0.87-1.00 of 6RL and covers the corresponding region of 806-881 Mb in the reference genome of Lo7. Oligo-FISH painting demonstrated that the region carrying Yr83 is syntenic to the distal end of long arm of homoeologous group 7 of the Triticeae genome. The developed wheat-6R lines carrying the Yr83 gene will be useful for breeding for rust resistance.
Galactic interaction as the trigger for the young radio galaxy MRC B1221−423

Mergers between a massive galaxy and a small gas-rich companion (minor mergers) have been proposed as a viable mechanism for triggering radio emission in an active galaxy. Until now the problem has been catching this sequence of events as they occur. With MRC B1221$-$423 we have an active radio galaxy that has only recently been triggered, and a companion galaxy that provides the "smoking gun". Using spectroscopic data taken with the VIMOS Integral Field Unit detector on the European Southern Observatory's Very Large Telescope, we have examined the distribution, ionization state and kinematics of ionized gas in this interacting system. We have also modelled the stellar continuum with synthesised spectra of stellar populations of different ages. From our study of the ionized gas, we have derived preliminary models for the geometry of the interaction, analysed the kinematic behaviour of the ionized gas, and examined the ionization mechanisms at work throughout the system. Our modelling of the stellar continuum allowed us to identify and date distinct stellar populations within the galaxy pair. We find evidence of multiple episodes of widespread starburst activity, and by dating these populations, we provide tentative insight into the history of the interaction.
Nitrogen Starvation Enhances the Production of Saturated and Unsaturated Fatty Acids in Aurantiochytrium sp. PKU#SW8 by Regulating Key Biosynthetic Genes

Nitrogen deprivation is known to improve lipid accumulation in microalgae and thraustochytrids. However, the patterns of fatty acid production and the molecular mechanisms underlying the accumulation of unsaturated and saturated fatty acids (SFAs) under nitrogen starvation remain largely unknown for thraustochytrids. In this study, batch culture experiments under nitrogen replete and nitrogen starvation conditions were performed, and the changes in the transcriptome of Aurantiochytrium sp. PKU#SW8 strain between these conditions were investigated. Our results showed improved yields of total fatty acids (TFAs), total unsaturated fatty acids, and total SFAs under nitrogen starvation, which suggested that nitrogen starvation favors the accumulation of both unsaturated and saturated fatty acids in PKU#SW8. However, nitrogen starvation resulted in a more than 2.36-fold increase of SFAs whereas a 1.7-fold increase of unsaturated fatty acids was observed, indicating a disproportionate increase in these groups of fatty acids. The fabD and enoyl-CoA hydratase genes were significantly upregulated under nitrogen starvation, supporting the observed increase in the yield of TFAs from 2.63 ± 0.22 g/L to 3.64 ± 0.16 g/L. Furthermore, the pfaB gene involved in the polyketide synthase (PKS) pathway was significantly upregulated under nitrogen starvation. This suggested that the increased expression of the pfaB gene under nitrogen starvation may be one of the explanations for the increased yield of docosahexaenoic acid by 1.58-fold. Overall, our study advances the current understanding of the molecular mechanisms that underlie the response of thraustochytrids to nitrogen deprivation and their fatty acid biosynthesis.
In Vivo Anticoagulant and Antithrombic Activity of Depolymerized Glycosaminoglycan from Apostichopus japonicus and Dynamic Effect–Exposure Relationship in Rat Plasma

Glycosaminoglycan from Apostichopus japonicus (AHG) and its depolymerized fragments (DAHGs) are anticoagulant fucosylated chondroitin sulfate. The aim of this study was to further evaluate the anticoagulant and antithrombic activity of AHG and DAHGs, as well as reveal the dynamic relationship between exposure and effect in vivo. The results demonstrated that AHG100 (Mw~100 kDa), DAHG50 (Mw~50 kDa), and DAHG10 (Mw~10 kDa) exhibited potent anticoagulant activity by inhibiting intrinsic factor Xase complex (FXase) as well as antithrombin-dependent factor IIa (FIIa) and factor Xa (FXa). These glycosaminoglycans markedly prevented thrombosis formation and thrombin-induced platelet aggregation in a dose- and molecular weight-dependent manner in vitro and in vivo. The further bleeding time measurement indicated that DAHG10 exhibited obviously lower hemorrhage risks than native AHG100. Following oral administration, DAHG10 could be absorbed into blood, further dose-dependently prolonging activated partial thromboplastin time (APTT) and thrombin time (TT) as well as inhibiting FXa and FIIa partially through FXase. Anticoagulant activity was positively associated with plasma concentration following oral administration of DAHG10. Our study proposed a new point of view to understand the correlation between effects and exposure of fucosylated chondroitin sulfate as an effective and safe oral antithrombotic agent.
DESTRUCTION THROUGH REPLICATION 1 Creative Destruction in Science

Drawing on the concept of a gale of creative destruction in a capitalistic economy, we argue that initiatives to assess the robustness of findings in the organizational literature should aim to simultaneously test competing ideas operating in the same theoretical space. In other words, replication efforts should seek not just to support or question the original findings, but also to replace them with revised, stronger theories with greater explanatory power. Achieving this will typically require adding new measures, conditions, and subject populations to research designs, in order to carry out conceptual tests of multiple theories in addition to directly replicating the original findings. To illustrate the value of the creative destruction approach for theory pruning in organizational scholarship, we describe recent replication initiatives re-examining culture and work morality, working parents’ reasoning about day care options, and gender discrimination in hiring decisions.
Diagnosis and therapy of psychology by means of systematicity theory

In the last decade there have been intense disputes about the scientific status of psychology especially in connection with the replicability of prominent effects in textbooks. Very different statements about the reasons for this situation have been given (for instance, sample sizes too small, inferential statistical considerations, faulty applications of evaluation methods, lack of theory building, etc.). All these reasons have their relative justification. What remains unresolved, however, is whether these deficiencies are really the fundamental reasons for the state of psychology as a science or just sur-face symptoms. Thus, one needs a diagnosis that can identify these fundamental reasons. For this purpose, the systematicity theory is suitable, which can address the scientific status of psychology, e.g., in distinction to everyday psychology, via nine aspects. These nine aspects are well founded and at the same time can give hints how to improve the scientific status of psychology. Only by advancing a common and integrated development of psychology will it be possible to improve its scientific status. Individual improvements of rather arbitrarily selected aspects cannot achieve that. The purposeful connection of diagnosis and therapy will be demonstrated by the example of psychology in order to guide the scientific process in a focused way.
The Risk Spiral: The Eﬀects of Bank Capital and Diversiﬁcation on Risk Taking

We present a model where bank assets are a portfolio of risky debt claims and analyze stockholders’ risk-taking behavior while considering the strategic interaction between debtors and creditors. We ﬁnd that: (1) as the leverage of a bank increases, risk shifting by borrowers increases, even if their leverage is unchanged (zombie lend-ing). (2) While the literature demonstrates that an increase in the co-movement of a loan portfolio increases the bank’s cost of default directly, we ﬁnd that the increase in co-movement causes an increase in risk shifting that further increases the cost of default (3) Risk shifting decreases with the diversiﬁcation of a loan portfolio.
Is islamic bank ﬁnancing related to interest rate ? Malaysian evidence based on ARDL approach

Over time the current world financial markets have become more closely correlated and dependent due to increased market integration. Islamic banking and finance had a rapid growth during the last two decades. This study applies Autoregressive Distributed Lag (ARDL) method to assess the relationship between the total financing of Malaysian Islamic Banks and interest rate, and it results that total financing is relatively a bit insensitive to changes in interest rate. The variance decompositions of two relevant variables such as, interest rate (DTB) and total financing (DFA) tend to indicate that they are fairly explained by themselves because the contributions of their own shocks to explaining their variances are 78% and 73% respectively. It shows that Islamic banks are relatively a bit resistant to interest rate as compared to the findings of some other researchers and also, debt-based financing by the conventional banks. Our study finds that the Islamic banking and finance can achieve the relative independence from the conventional banks and interest rate through Islamic financing and practices. This is rather a unique contribution of the paper with strong policy implications.
The Relationship between Perfectionism and Social Anxiety: A Moderated Mediation Model

Social anxiety is one of the mental health problems associated with perfectionism. The present study investigated the possible mediation of perceived stress in the relationship between perfectionism and social anxiety, and whether this mediation depends on the level of trait mindfulness. A total of 425 college students (female: 82.9%; mean age: M = 19.90 ± 1.06 years old) completed the Multidimensional Perfectionism Scale (MPS), the Chinese Perceived Stress Scale (CPSS), the Interaction Anxiousness Scale (IAS), and the Five-Facet Mindfulness Questionnaire (FFMQ). After controlling for age and gender, the moderated mediation analysis suggested that perfectionism significantly and positively predicted social anxiety and that perceived stress mediated the link between perfectionism and social anxiety. In addition, the indirect effect of perfectionism on social anxiety was moderated by trait mindfulness. Specifically, the indirect effect was weaker among the individuals with a high level of mindfulness compared to those with a low level of mindfulness. The findings of this study suggest that trait mindfulness significantly moderates the indirect effect of perfectionism on social anxiety via perceived stress.
Curcumin protects PC12 cells from a high glucose-induced inflammatory response by regulating the miR-218-5p/TLR4 axis

Background: Curcumin exerts a protective effect on diabetic encephalopathy (DN), It is known for its potent neuroprotective, anti-inflammatory, antioxidant, and anticancer properties. However, the underlying mechanisms of curcumin’s neuroprotective effects resulting from high glucose (HG)-induced injuries remain unknown. The purpose of this study is to identify the protective mechanism of Curcumin in the DN. Methods: In this study, pheochromocytoma cells (PC12 cells) were pretreated with different concentrations of Curcumin and then co-treated with Curcumin and glucose for 48 hours, and the cell viability was evaluated by CCK-8, the expression of the inflammatory mediators were detected by ELISA, the miR-218-5p and toll-like receptors (TLR4) level were examined by both quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, the potential target genes of miR-218-5p were identified using luciferase reporter assay. Results: The viability of PC12 cells treated with HG was significantly reduced in a dose- and time-dependent manner. Cotreatment of curcumin with HG significantly increased cell viability. Curcumin inhibited the expression of the inflammatory mediators, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), and induced the expression of the anti-inflammatory mediator interleukin-10 (IL-10). Curcumin upregulated the levels of miR-218-5p and downregulated the expression of TLR4 in HG-treated PC12 cells. The curcumin-induced anti-inflammatory effect was abrogated by a miR-218-5p inhibitor and overexpression of TLR4. The results suggest that curcumin ameliorates the inflammatory response by upregulating miR-218-5p levels in PC12 cells. Conclusions: Our results indicate a protective role for curcumin in PC12 cells and suggest that it should be considered for the prophylactic treatment of DN in the future.
A new marker of short-term mortality and poor outcome in patients with acute ischemic stroke: Mean platelet volume-to-lymphocyte ratio

Background: The mean platelet volume-to-lymphocyte ratio (MPVLR), as a novel marker of thrombosis and inflammation, has been demonstrated to be closely linked to poor cardiovascular disease prognosis. However, the correlation between MPVLR and acute ischemic stroke (AIS) remains unclear. This study, therefore, aimed to clarify the relationship between MPVLR and the short-term prognosis of AIS. Methods: A total of 315 patients with first-time AIS diagnoses were recruited and divided into 3 groups based on the tri-sectional quantiles for MPVLR on admission: group 1 (N = 105) with a MPVLR ≤ 4.93, group 2 (N = 105) with a MPVLR of 4.94 to 7.21, and group 3 (N = 105) with a MPVLR ≥ 7.22. All patients were followed-up for 3 months, and death within 3 months was defined as the endpoint. Baseline characteristics, stroke severity, and functional outcomes were evaluated. Results: The Spearman’s correlation coefficient test showed that MPVLR was significantly positively correlated with the National Institutes of Health Stroke Scale score (R = 0.517, P < .001). Multivariate analysis revealed that MPVLR was an independent predictor of both short-term mortality (adjusted odds ratio [OR] 1.435, P < .001) and poor outcome (adjusted OR 1.589, P < .001). The receiver operating characteristic (ROC) curve analysis showed that the best cutoff value of MPVLR for short-term mortality and poor outcome were 6.69 (sensitivity: 86.4%, specificity: 68.6%) and 6.38 (sensitivity: 78.8%, specificity: 72.3%), respectively. Conclusions: MPVLR on admission was positively associated with stroke severity. An elevated MPVLR is an independent predictor of short-term mortality and poor outcome after AIS.