Miracle-dz/UniFAR-FTUs huggingface dataset:
Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice

Drug-induced liver injury (DILI) is the main cause of liver damage mediated by the excretion of toxic active drug metabolites. Omega-3 fatty acids and vitamin C have potent antioxidant, anti-inflammatory, and antiapoptotic effects that could offer protection against oxidative stress and liver damage. This study evaluated the hepatoprotective effect of omega-3 and vitamin C alone as well as in a combined form in methotrexate- (MTX-) induced acute liver injury in mice. Male ICR mice of seven groups (7 mice per group) were used. Groups 1 (control group) and 2 (MTX) received 0.9% saline/day (po) for 9 days. Groups 3 and 4 received 100 and 200 mg/kg bw/day omega-3 (po), respectively, for 9 days. Groups 5 and 6 received 100 and 200 mg/kg bw/day vitamin C (po), respectively, for 9 days, while group 7 received omega-3 (100 mg/kg bw/day) and vitamin C (100 mg/kg bw/day) (po) for 9 days. All animals in groups 2 to 7 received 20 mg/kg/day MTX (I.P.) once on the 10th day. Our results revealed that MTX significantly induced the elevation of transaminases, alkaline phosphates (ALP), lactate dehydrogenase (LDH), and malonaldehyde (MDA) while depleting the levels of superoxide dismutase (SOD) and glutathione (GSH) when compared to the control group. Treatment with omega-3 fatty acids or vitamin C significantly attenuated the antioxidants and biochemical alterations in a dose-independent manner. Our molecular docking study of ligand-receptor interaction revealed that both ascorbic acid and omega-3 docked well to the binding cavity of LDH with high binding affinities of –5.20 and –4.50 kcal/mol, respectively. The histopathological features were also improved by treatment with omega-3 and vitamin C. The combined form of omega-3 and vitamin C showed a remarkable improvement in the liver enzymes, oxidative stress biomarkers, and the histopathological architecture of the mice. Conclusively, the combination of omega-3 and vitamin C demonstrated a synergistic therapeutic effect against MTX-intoxicated mice, hence representing a potential novel strategy for the management of drug-induced liver disorders.
The Influence of Antibiotic Resistance on Innate Immune Responses to Staphylococcus aureus Infection

Staphylococcus aureus (S. aureus) causes a broad range of infections and is associated with significant morbidity and mortality. S. aureus produces a diverse range of cellular and extracellular factors responsible for its invasiveness and ability to resist immune attack. In recent years, increasing resistance to last-line anti-staphylococcal antibiotics daptomycin and vancomycin has been observed. Resistant strains of S. aureus are highly efficient in invading a variety of professional and nonprofessional phagocytes and are able to survive inside host cells. Eliciting immune protection against antibiotic-resistant S. aureus infection is a global challenge, requiring both innate and adaptive immune effector mechanisms. Dendritic cells (DC), which sit at the interface between innate and adaptive immune responses, are central to the induction of immune protection against S. aureus. However, it has been observed that S. aureus has the capacity to develop further antibiotic resistance and acquire increased resistance to immunological recognition by the innate immune system. In this article, we review the strategies utilised by S. aureus to circumvent antibiotic and innate immune responses, especially the interaction between S. aureus and DC, focusing on how this relationship is perturbed with the development of antibiotic resistance.
Development of Electronic Modules Based on Critical Thinking Skills on Vibration, Waves, and Sound Materials for Junior High School Students

Electronic learning resources are needed in accordance with the demands of basic competencies in learning and can be used by teachers and students as a means of independent learning at home or at school. This study aims to develop an electronic module on the material of vibration, waves and sound that is valid and practical. The Rowntree development model used consists of three stages, namely planning, development and evaluation stages. At the evaluation stage, the researcher used the Tessmer evaluation stage, which consisted of the self-evaluation, expert review, one-to-one evaluation, and small group evaluation stages. The research subjects were students of class VIII.2 SMP N 1 Prabumulih. The research instrument used was observation, student needs questionnaire, expert validation questionnaire and student perception questionnaire. The data analysis technique used walkthrough and questionnaire methods. The resulting product is an electronic module of vibration, wave and sound material using the Flip PDF Professional program. The results of the research show: 1) the development of an electronic module based on critical thinking skills has been carried out through a development procedure that includes 3 stages. 2) the acquisition of the research results obtained content validation of 4.50 (strong valid), content validation of critical thinking skills of 4.61 (strong valid), design validation of 4.72 (strong valid), and language validation of 4 . 50 (strong valid). So, the total average of the results of the content validation assessment, the content of critical thinking skills, design, and language is 4.60 including the "strong valid" category. 3) To produce a practical electronic module with research results, the average results of the assessment of student responses in the one-to-one evaluation stage is 4.55 with the "Extremely useful" category and the average results of the assessment of student responses in the questionnaire are the small group evaluation stage is 4.60 with the "Extremely useful" category. The electronic module based on critical thinking on vibration, waves and sound material that has been developed is suitable for use as teaching material for class VIII junior high school students.
Metabolic Syndrome Is Associated with Cataract in a Large Taiwanese Population Study

Cataract is the leading cause of blindness worldwide, and metabolic syndrome (MetS) is a known risk factor. In this study, we investigated the association between the risk of cataract with MetS and its components in a large-scale study. Data were derived from the Taiwan Biobank, and 121,380 individuals were included. The NCEP-ATP III criteria modified for use in an Asian population were used to define MetS and its components. The occurrence of cataract was identified through a standardized interview and self-reported questionnaire. Multivariable analysis showed that MetS (OR, 1.129; 95% CI, 1.0175–1.184; p < 0.001), low high-density lipoprotein (HDL)-cholesterol (OR, 1.057; 95% CI, 1.005–1.113; p = 0.032), and hyperglycemia (OR, 1.162; 95% CI, 1.108–1.218; p < 0.001) were significantly associated with cataract. Furthermore, a stepwise increase in the prevalence of cataract corresponding to the number of MetS components was found. The presence of three MetS components (vs. 0; OR, 1.103; 95% CI, 1.024–1.188; p = 0.010), four MetS components (vs. 0; OR, 1.137; 95% CI, 1.040–1.242; p = 0.005), and five MetS components (vs. 0; OR, 1.208; 95% CI, 1.059–1.378; p = 0.005) were significantly associated with cataract. In conclusion, significant associations were found between a high incidence of cataract with MetS and its components, including low HDL-cholesterolemia and hyperglycemia. Further, a stepwise increase in the prevalence of cataract corresponding to the number of MetS components was also found. The results of this study indicate that MetS may increase the development of cataract in Taiwan.
Serum P-Cresyl Sulfate Level Is an Independent Marker of Peripheral Arterial Stiffness as Assessed Using Brachial-Ankle Pulse Wave Velocity in Patients with Non-Dialysis Chronic Kidney Disease Stage 3 to 5

p-Cresyl sulfate (PCS) is a uremic toxin that causes cardiovascular injury and progression in patients with chronic kidney disease (CKD). Peripheral arterial stiffness (PAS) as measured using the brachial-ankle pulse wave velocity (baPWV) is considered a valuable predictor of cardiovascular event risk in the general population. The study investigated the correlation between serum PCS levels and PAS (baPWV > 18.0 m/s) in 160 patients with stage 3–5 CKD. Liquid chromatography–mass spectrometry was used to assay serum PCS levels. PAS was detected in 54 patients (33.8%), and it was linked to older age, a higher prevalence of hypertension, higher systolic and diastolic blood pressure, higher serum calcium–phosphorus product and PCS levels, and lower height and body weight. Multivariable logistic regression analysis for independent factors associated with PAS illustrated that, in addition to age and diastolic blood pressure, serum PCS levels exhibited an odds ratio (OR) of 1.098 (95% confidence interval = 1.029–1.171, p = 0.005). These findings demonstrated that serum PCS levels were associated with PAS among patients with stage 3–5 CKD.
Prevalence and 11-Year Incidence of Cataract and Cataract Surgery and the Effects of Socio-Demographic and Lifestyle Factors

Purpose To assess the impact of cataract in ageing population by evaluating the prevalence, incidence, and background factors of cataract and cataract surgery. Patients and Methods Two health examination surveys representing Finnish population in 2000 and 2011 included 7380 and 5930 participants aged 30 years or older with cataract status known. An 11-year follow-up included 4840 persons who participated in both the surveys. The data include information on physician-made diagnoses, socio-demographic factors, and lifestyle factors based on self-reported assessment. Cataract diagnoses and surgeries recorded in the Finnish Care Register for Health Care were linked to the survey data. Cataract patients were compared to those without cataract using logistic regression. Differences in cataract surgery age were evaluated using linear regression. Univariable and multivariable models were included. Results During 2000–2011, the prevalence of cataract increased from 8.8% to 13.6% and cataract surgery from 5.7% to 8.9% in a representative sample of the Finnish adult population. Cataract and cataract surgery were associated with age, smoking, and high alcohol consumption. Cataract was also associated with female gender and low income in 2000, but this association declined during the 11 years. Smoking and high alcohol consumption were associated with younger surgery age. Conclusion The prevalence of cataract and cataract surgery is increasing with the ageing of the population. The increase in cataract surgery is likely also reflecting the improvements in eye care. The possibility to equally use health-care services throughout a country can reduce the impact of socio-demographic status. Healthy lifestyle delays the development of cataract, whereas smoking and high alcohol consumption are associated with earlier cataract development. Therefore, the availability of cataract services and promotion of healthy lifestyle will be the key to prevent the detrimental effects of cataract on patients and the society in countries where the population is rapidly ageing.
Green Economy—Green Jobs in the Context of Sustainable Development

Europe is in the middle of an energy crisis, exacerbated in large part by skyrocketing gas costs. Renewable energy is critical in this environment for decreasing Europe’s reliance on imported energy; boosting renewables in Europe requires a ‘New Energy Compact’—a coordinated effort throughout Europe to build more renewable energy capacity. The purpose of this research is to examine the structure of renewable energy production in Romania between 2010 and 2020, as well as the green employment produced by the renewable energy sector in Romania between 2010 and 2019. Using the Markov chain approach, it was predicted that in 2025, the hydropower industry’s employees would account for the biggest proportion of the overall average number of workers engaged in the renewable energy production sector in Romania (74.68%). Solar energy production employees will account for 14.31% of the average number of workers in the renewable energy production sector, biomass energy production employees will account for 5.8%, and wind energy production employees will account for 5.2% of the average number of workers in the green energy sector.
Bee glue scientometrics and therapeutics: phytochemical screening, methodological trends and prospects

Abstract The objective of this scientometric review is to search the literature in order to examine the uses and effects of propolis and highlight emerging trends and research gaps in relation to this natural product. The review also systematizes the study models used, methodological trends, and the main obstacles faced in the collection, extraction, and concentration of the raw material, as well as the emerging challenges in the standardization of extracts and their bioactive compounds for use in pharmacology and experimental therapeutics. The search revealed that propolis has a wide range of effects, including anti-inflammatory, healing, antioxidant, antimicrobial, analgesic, and anticarcinogenic activities, arising mainly from its polyphenolic compounds. A multivariate analysis of canonical correspondence was used to correlate these compounds with these effects. In order to identify and retrieve the most important published literature in this field in the last decade, a database search (PubMed, Scopus, and Web of Science) was performed. The search terms were: propolis, biological properties, therapeutics, adjuvant, anti-inflammatory, antioxidant, antimicrobial, healing, anticarcinogenic, antinociceptive, neuroregenerative, and toxicity, as well as their respective combinations. The multivariate analysis clarified the effects played by the propolis metabolites. The review also revealed that few articles have explored the antinociceptive and neurological effects of propolis, highlighting a gap in this research field, and the possible neglect of important targets for the development of drugs for neurological diseases and the treatment of pain. The results also reinforced the need for more studies on living systems and showed a trend for methods using superfluid extraction, with ethanol being the most suitable solvent. The review also indicated the potential use of propolis extract in nutraceutical and as an adjuvant, enhancing the effects of other drugs.
Antarctic-Scale Ice Flow Lines Map Generation and Basin Delineation

Ice flow lines are the most dominant feature of ice sheet surfaces. Accurate delineation of basins is a prerequisite for mass balance. We therefore propose a new weight balance-based approach to extract the present most comprehensive ice flow lines and then re-delineate the Antarctic basin on this basis. In our approach, we define three impact factors to represent directional accuracy, smoothness, and physical character. Following this, a weight balance-based method is proposed, in which those factors are integrated via weights, to determine the pointing pixels (points or subpixels of the ice flow line). After that, the ice flow lines are continuously tracked. Finally, Antarctic basins were re-delineated based on it. The results indicate that the derived ice flow lines exhibit a rational ice flow pattern against the DEM and the proposed method remarkably improves the performance of results. Furthermore, compared with the Antarctic IMBIE (Ice sheet Mass Balance Inter-Comparison Exercise) basins, the redivided basins exhibit slight diversity, with differences in area and length of less than 11% and a directional accuracy of less than 1° (covering more than 90% of area). As a result, the redivided basins are beneficial to the investigation of the in-depth mechanism of ice shelf calving and mass balance in the Antarctic.
Induced Circulation by Plunging and Submerged Jets in Circular Water Storage Tanks Using CFD

Water circulation in storage tanks significantly impacts water quality in distribution networks since old water tends to have low residual chlorine concentrations that are insufficient to neutralize microbial regeneration. Their large capacity and long residence times result in uneven mixing, which can accelerate the disinfectant decay and the formation of potentially carcinogenic disinfection by-products. The phenomenon is strongly related to the tank inflow conditions, since there are no active mixing devices. This paper presents a comprehensive analysis of the flow dynamics in circular storage tanks using a three-dimensional computational fluid dynamics model. The main motivation is that the inflow—which mixing processes rely on—strongly influences the circulations. The numerical analysis provided includes a thorough investigation of interest in understanding flow dynamics for two inflow configurations: (i) the plunging jet modelling and comparison with published experimental data and (ii) the submerged jet as an improvement measurement for these storage tanks.
Overexpression of Neuregulin-1 Type III Has Impact on Visual Function in Mice

Schizophrenia is associated with several brain deficits, including abnormalities in visual processes. Neuregulin-1 (Nrg1) is a family of trophic factors containing an epidermal growth factor (EGF)-like domain. It is thought to play a role in neural development and has been linked to neuropsychiatric disorders. Abnormal Nrg1 expression has been observed in schizophrenia in clinical studies. Moreover, in schizophrenia, there is more and more evidence found about pathological changes of the retina regarding structural, neurochemical and physiological parameters. However, mechanisms of these changes are not well known. To investigate this, we analysed the function of the visual system using electroretinography (ERG) and the measurement of visual evoked potentials (VEP) in transgenic mice overexpressing Nrg1 type III of three different ages (12 weeks, 24 weeks and 55 weeks). ERG amplitudes tended to be higher in transgenic mice than in control mice in 12-week old mice, whereas the amplitudes were almost similar in older mice. VEP amplitudes were larger in transgenic mice at all ages, with significant differences at 12 and 55 weeks (p values between 0.003 and 0.036). Latencies in ERG and VEP measurements did not differ considerably between control mice and transgenic mice at any age. Our data show for the first time that overexpression of Nrg1 type III changed visual function in transgenic mice. Overall, this investigation of visual function in transgenic mice may be helpful to understand corresponding changes that occur in schizophrenia, as they may find use as biomarkers for psychiatric disorders as well as a potential tool for diagnosis in psychiatry.
Systemic Thrombolysis and Endovascular Therapy for Large Vessel Occlusion Acute Ischemic Stroke

Evidence was mixed, with higher-quality evidence suggesting that there were no differences between treatment with alteplase before endovascular therapy or endovascular therapy alone in patients with large vessel occlusion acute ischemic stroke for outcomes related to safety and efficacy, and lower-quality evidence indicating a difference between the groups for certain outcomes.
Localized actuation of temperature responsive hydrogel-layers with a PCB-based micro-heater array

Space-resolved stimulation of active hydrogel layers can be achieved for example by using a micro-heater array. In the current work, we present the interaction of (i) such a rigid array of heating elements that can be selectively activated and (ii) an active thermo-responsive hydrogel layer that responds to the local stimulus change. Due to the respective local actuation, (iii) the surface form of a passive top-layer can be manipulated. We present continuum-based simulative predictions based on the Temperature Expansion Model and compare them to experimental outcomes for the system.
Cycle time-oriented mid-term production planning for semiconductor wafer fabrication

Wafers are produced in an environment with uncertain demand and failure-prone machines. Production planners have to react to changes of both machine availability and target output, and revise plans appropriately. The scientific community mostly proposes WIP-oriented mid-term production planning to solve this problem. In such approaches, production is planned by defining targets for throughput rates and buffer levels of selected operations. In industrial practice, however, cycle time-oriented planning is often preferred over WIP-oriented planning. We therefore propose a new linear programming formulation, which facilitates cycle time-oriented mid-term production planning in wafer fabrication. This approach plans production by defining release quantities and target cycle times up to selected operations. It allows a seamless integration with the subordinate scheduling level. Here, least slack first scheduling translates target cycle times into lot priorities. We evaluate our new methodology in a comprehensive simulation study. The results suggest that cycle time-oriented mid-term production planning can both increase service level and reduce cycle time compared to WIP-oriented planning. Further, it requires less modelling effort and generates plans, which are easier to comprehend by human planners.
Sustainable Management of Salt Slag

The management of salt slag, a waste from the secondary aluminum industry, is associated with huge environmental concerns due to the risk of atmospheric pollution (emission of toxic gases), groundwater contamination (high salt content that can percolate and cause an increase in salinity) and soil unavailability (large extensions required for disposal). Therefore, the development of a sustainable process for its treatment and recovery is of the utmost importance. In this work, a two-step process for the valorization of salt slag was developed that rendered zeolite as the main added-value product and NaCl and NH3 as byproducts. First, salt slag was hydrolyzed at 90 °C and at a solid/water ratio of 1/3. More than 90% of salt and ~90% of ammonia were recovered. In a second step, the hydrolyzed slag was completely transformed into a NaP zeolite under mild hydrothermal conditions. The zeolite exhibited specific surface area (17 m2 g−1), cation exchange capacity (2.12 meq g−1) and zeta potential (−52 mV) values that represent good characteristics for use in the removal of metal ions from aqueous effluents. The transformation of salt slag into zeolite can be considered a sustainable process with a high contribution to the circular economy.