Miracle-dz/UniFAR-FTUs huggingface dataset:
Longitudinal Study of Hepatitis B immunization in Healthcare Workers in One Egyptian Center

Objective: We have performed this study to: 1- Evaluate the prevalence of hepatitis B virus surface antigen (HBsAg) and antibody to hepatitis C virus (anti-HCV) in health care workers at start of the study and after 5 years to evaluate the risks of seroconversions 2- Evaluate the rates of antibodies titer in HCWs both after HBV immunization and after 5 years from vaccination. Methods: The study included 302 health care workers in Mansoura University Children hospital, Egypt from December 2009 till February 2015. HCWs receive vaccination for HBsAg and the states of antibodies titer for HBsAg were evaluated after complete vaccination and after 5 years. Also the anti-HCV and HBsAg were determined by immunoassay at start of the study and after 5 years. Results: Ninety percent of HCWs developed anti-HBsAg above 10mIU/ml. The non-responsive of HCWs was 10%, and HCWs with levels between 10-100 mIU/ml were 21.7%. The results of HCV IgG and HBsAg among HCWs at the start of the study were 4.3% and 0.7% respectively. After 5 years, the rates of HCV IgG and HBsAg were 18.2% and 4.4%% respectively. The seroconversion rates showed around four folds increase in HCVIgG and six folds increase in HBsAg the increase was highly significant (P=0.0001, P=0.006 respectively). The presence of protective antibodies titer after five years for anti-HBs was 59.8%. HCWs that have less 10mIU/ml anti-HBs were 40.3%, HCWs who had levels between 10-100 mIU/ml were 14.5% and HCWs with levels more than 100mIU/ml were 45.3%. Conclusions: The present study highlights an important finding among some Egyptian health care workers. There is good response for hepatitis B vaccination after primary vaccination however, there are some non-responders and hypo responders so the evaluation of antibodies levels after vaccination is important for application of revaccination or/and booster dose application for achieving of utmost protection level. The decline of antibodies level after 5 years is remarkable necessity for the evaluation of health care workers for antibodies levels for booster dose administration. The seroconversion for hepatitis C and B viruses were significant among our health care workers. Strict adherence to infection control guidelines should be implanted.
Charmonium suppression at RHIC: Signature of a strongly-interacting QGP, not a weakly interacting

Following a recent work on equation of state for strongly interacting quark-gluon plasma [J. Phys. G: Nucl. Part. Phys. 32, 993 (2006)], we revisited the equation of state by incorporating the non-perturbative effects in the deconfined plasma phase. Our results on thermodynamic observables viz. pressure, energy density, speed of sound etc. nicely fit with the lattice equation of state for gluon, massless and as well massive flavored plasma. Motivated by this agreement with lattice results, we have employed our equation of state to estimate the quarkonium suppression in an expanding, dissipative strongly interacting QGP produced in relativistic heavy-ion collisions and our prediction matches exactly with the recent PHENIX data on the centrality dependence of $J/\psi$ suppression in Au+Au collisions at BNL RHIC. We have also predicted for the $\Upsilon$ suppression in Pb+Pb collisions at LHC energy which could be tested in the ALICE experiments at CERN LHC.
Stabilization of LPV systems: state feedback, state estimation and duality

In this paper, the problem of the stabilization of linear parameter varying systems by means of gain scheduling control is considered. This technique consists on designing a controller which is able to update its parameters on-line according to the variations of the plant parameters. We first consider the state feedback case and we show a design procedure based on the construction of a Lyapunov function for discrete-time LPV systems in which the parameter variations are affine and occur in the state matrix only. This procedure produces a nonlinear static controller. We show that, differently from the robust stabilization case, we can always derive a linear controller, that is nonlinear controllers cannot outperform linear ones for the gain scheduling problem. Then we show that this procedure has a dual version, which leads to the construction of a linear gain scheduling observer. The two procedures may be combined to derive an observer-based gain scheduling compensator.
of diagnostic tests to support

: The aim of the deliverable 1.5. is to present a summary of the results obtained in the Round 2 of the test performance studies (TPS) organized by WP1 on six prioritized pests. Tests selection for each TPS was conducted following the “Common rules for selection of tests for TPS” and based on the “Weighted criteria for selection of tests for TPS”, both described in deliverable D1.1 (Minimum performance parameters to select tests for validation and selection of laboratories for TPS), while the list of selected tests for each TPS is available and explained in deliverable D1.3 (List of tests for validation - Round 2). TPS participants were selected following the “Common rules for selection of participants for TPS” and based on the “Criteria for selection of participants of TPS”, also both described in deliverable D1.1. For each of the six TPSs, the methodology used to perform the tests, the results of preliminary studies to select the tests, the results of the TPS and their thorough analysis and interpretation are
BCTT_A_317682 447..457

1Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, 45363, Indonesia; 2Central Laboratory, Universitas Padjadjaran, Jatinangor, West Java, 45363, Indonesia; 3Department of Chemistry, Faculty of Mathematic and Sciences, Universitas Padjadjaran, Jatinangor, West Java, 45363, Indonesia Introduction: Breast cancer is the second most common cancer in women globally, and the incidence rate has increased annually. Traditional medicine is frequently used as a cancer treatment, and soursop or Annona muricata L (A. muricata) is a traditional medicinal plant that has been widely used as an anticancer treatment and requires more thorough study. Methods: In this research, we prepared ethanol extract and three solvents, ie, ethyl acetate, n-hexane and water fractions of A. muricata leaves and assessed their antiproliferation and cytotoxic activity on MCF7 breast cancer cells compared with that on CV1 normal kidney cells; observation of cell morphology by stained with mixture of propidium iodide and 4ʹ,6-diamidino-2-phenylindole indicated that this treatment induced an ongoing process of apoptotic cell death in MCF7 cells. To clarify the cell death mechanism via apoptosis, we assessed the mRNA expression in the caspase cascade of caspase-9, caspase-3, and PARP-1, and anti-apoptotic, Bcl-2 which mediated cytotoxic activity of extracts and ethyl acetate fractions of A. muricata leaves against MCF7 cells. Results: The ethanol extract, ethyl acetate, n-hexane, and water fractions of A. muricata leaves had IC50 values of 5.3, 2.86, 3.08, and 48.31 μg/mL, respectively, in MCF7 cells but had no activity in CV1 cells. The high cytotoxic activity of A. muricata leaves was reflected by changes in the morphology of cancer cells that appeared after 6 h exposure to A. muricata leaf extract and ethyl acetate fraction; the membrane and nucleus of cells undergoing apoptosis were characterized by the rupture and loss of membranes and nuclei. The mechanism that mediates this cytotoxic activity in MCF7 cells was mediated through a decrease in the expression of Bcl-2 mRNA and an increase in caspase-9 and caspase-3 mRNA expression. Conclusion: Therefore, the leaves of the medicinal plant A. muricata contained compounds that on extraction exerted a highly effective activity as an anticancer treatment for breast cancer via induced apoptotic cell death.
What Every Atmospheric Scientist Should Know

S E P T E M B E R 2 0 2 0 E1512 ABSTRACT: Remote sensing instruments are heavily used to provide observations for both the operational and research communities. These sensors do not provide direct observations of the desired atmospheric variables, but instead, retrieval algorithms are necessary to convert the indirect observations into the variable of interest. It is critical to be aware of the underlying assumptions made by many retrieval algorithms, including that the retrieval problem is often ill posed and that there are various sources of uncertainty that need to be treated properly. In short, the retrieval challenge is to invert a set of noisy observations to obtain estimates of atmospheric quantities. The problem is often complicated by imperfect forward models, by imperfect prior knowledge, and by the existence of nonunique solutions. Optimal estimation (OE) is a widely used physical retrieval method that combines measurements, prior information, and the corresponding uncertainties based on Bayes’s theorem to find an optimal solution for the atmospheric state. Furthermore, OE also allows the relative contributions of the different sources of error to the uncertainty in the final retrieved atmospheric state to be understood. Here, we provide a novel Python library to illustrate the use of OE for inverse problems in the atmospheric sciences. We introduce two example problems: how to retrieve drop size distribution parameters from radar observations and how to retrieve the temperature profile from ground-based microwave sensors. Using these examples, we discuss common pitfalls, how the various error sources impact the retrieval, and how the quality of the retrieval results can be quantified.
Diurnal Variation of Cb-Clusters over China and Its Relation to Large-Scale Conditions in the Summer of 1979.

The appearance frequency of Cb-clusters and its diurnal variation were examined in relation to large-scale conditions based on the observational data from June to August 1979. The analysis was applied to the three stages in the seasonal march in that year, i.e., Pre-Meiyu (1-17 June), Meiyu (20 June-22 July) and Mid-summer (23 July-17 August). The main results are as follows. (1) The Cb-clusters appeared frequently not only in the Baiu frontal zone but also in North to Northeast China (Area N1) in Meiyu, and in Central China (Area C2) in Mid-summer. A remarkable diurnal variation of appearance frequency of the Cb-clusters with an evening maximum was observed in Area N1 in Meiyu and Area C2 in Mid-summer. The daily maximum of ground surface temperature in these two cases was very high. (2) In Area N1 in Meiyu, the Cb-clusters with diurnal variation were mainly embedded in large-scale cloud systems corresponding to slow-moving upper-level lows or troughs. The specific humidity in the lower layer increased from Pre-Meiyu to Meiyu. These two factors, as well as the strong surface heating, would provide a favorable condition for the frequent appearance of Cb-clusters due to the increase of convective instability. The large-scale horizontal convergence in the lower layer was stronger at 12 UTC (20 BST) than at 00 UTC (08 BST), which would lead to the development of Cb-clusters in the evening. (3) Area C2 was covered by the subtropical high, and the low-level divergence was generally stronger at 12 UTC than at 00 UTC. In spite of these conditions, the isolated Cb-clusters developed very frequently in the evening. The very strong surface heating in the daytime could contribute to release of the strong convective instability by generating meso-scale upward motion as a trigger.
Word Sense Induction for Russian Texts Using BERT

—This article considers an unsupervised approach called word sense induction for resolving word sense disam-biguation in the natural languages. The resolution of word sense disambiguation is one of the most important tasks in the natural text processing area, as it is the key problem of many other tasks in this ﬁeld. Clustering of vector word representations was used to resolve sense ambiguity. Word translation into the vector representation was done with the RuBERT language model which was initialized with BERT and pre-trained on the Russian part of Wikipedia and news data language model. The Afﬁnity Propagation algorithm was applied for clustering in this work. The main feature of this algorithm is not to require the number of clusters as an input parameter. Using this algorithm along with the BERT model led us to the resulting score 0.81 ARI 1 that is comparable to other methods and can be used to resolve the word sense disambiguation. The results of this work could be used in such areas as information search, information extracting, and different tasks connected with semantic networks.
The kinematics and chemical stratification of the type Ia supernova remnant 0519-69.0 - An XMM-Newton and Chandra study

We present a detailed analysis of the XMM-Newton and Chandra X-ray data of the young type Ia supernova remnant SNR 0519-69.0, which is situated in the Large Magellanic Cloud. We used data from both the Chandra ACIS and XMM-Newton EPIC MOS instruments, and high resolution X-ray spectra obtained with the XMM-Newton reflection grating spectrometer (RGS). Our analysis of the spatial distribution of X-ray line emission using the Chandra data shows that there is a radial stratification of oxygen, intermediate mass elements (IME) and iron, with the emission from more massive elements peaking more toward the center. Using a deprojection technique we measure a forward shock radius of 4.0±0.3 pc and a reverse shock radius of 2.7±0.4 pc. We took the observed stratification of the shocked ejecta into account in the modeling of the X-ray spectra, for which we used multi-component non-equilibrium ionization models, with the components corresponding to layers dominated by one or two elements. An additional component was added in order to represent the shocked interstellar medium, which mostly contributed to the continuum emission. This multicomponent model fits the data adequately, and was also employed to characterize the spectra of distinct regions extracted from the Chandra data. From our spectral analysis we find that the approximate fractional masses of shocked ejecta for the most abundant elements are: ≈ 32%, ≈ 7%/5%, ≈ 1% and ≈ 55%. From the continuum component we derive a circumstellar density of nH = 2.4 ± 0.2 cm-3. This density, together with the measurements of the forward and reverse shock radii suggest an age of 0519-69.0 of 450±200 yr, somewhat lower than, but consistent with the age estimate based on the extent of the light echo (600±200 yr). Finally, from the high resolution RGS spectra we measured a Doppler broadening of σ = 1873 ± 50 km s-1, from which we derive a forward shock velocity of vFS = 2770 ± 500 km s-1. We discuss our results in the context of single degenerate explosion models, using semi-analytical and numerical modeling, and compare the characteristics of 0519-69.0 with those of other type Ia supernova remnants.
On simple families of cyclic polynomials

We study polynomials giving cyclic extensions over rational function fields with one variable satisfying some conditions. By using them, we construct families of cyclic polynomials over some algebraic number fields. And these families give non-Kummer (or non-Artin-Schreier) cyclic extensions. In this paper, we see that our polynomials have two nice arithmetic properties. One is simplicity: our polynomials and their discriminants have more simple expressions than previous results, e.g. Dentzer (1995), Malle and Mazat (1999) and Smith (1991), etc. The other is a systematic property: if one of our polynomials f gives an extension L/K, then for every intermediate field M we can easily find polynomials giving M/K from f systematically.
Intelligent Transport Systems (ITS): An Approach to Traffic Congestion Challenges in Enugu Meteropolis

Mobility is a necessity but the consequence is the resultant congestion from increase in traffic volume. At a time the solution was the construction of more transport infrastructures, but in the face of a persistent decrease in land other methods of tackling the ever increasing transport problems gave birth to systems such as Intelligent Transport Systems. This study attempts to assess the role of Intelligent Transport System in solving the problem of traffic congestion by identifying the existing system of traffic management in Enugu Urban and determining the potential for a more effective traffic management system through intelligent transport systems. Primary sources of data were employed. Using purposive sampling and simply random sampling 400 road users and 122 staff of Enugu State Ministry of Transport were interviewed through well-constructed questionnaires with a return rate of 94.5% and 94% respectively. Descriptive statistics were employed. The results were compiled using statistical package for social sciences (SPSS). The study revealed that Automated Traffic Signal and Control, Traffic Wardens, Channelization to Road Signs; are the existing systems of traffic management and was found to be ineffective in tackling the challenges of traffic congestion. It was also discovered that the introduction of some forms of Intelligent Transport Systems would go a long way in improving the control and management of traffic. The study therefore recommends the integration of Intelligent Transport Systems for operational efficiencies and inter-jurisdictional coordination benefits that result in comprehensive and improved transport system management.
CMAR_A_241095 4283..4297

Rongtao Pan Haiyan Zhou 1Department of Oncology, Taishan Hospital of Shandong Province, Taian 271000, Shandong, People’s Republic of China; 2Department of Medical Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, People’s Republic of China Background: Drug resistance restrains the effect of drug therapy in non-small cell lung cancer (NSCLC). However, the mechanism of the acquisition of drug resistance remains largely unknown. This study aims to investigate the effect of exosomal lncRNA H19 on erlotinib resistance in NSCLC and the underlying mechanism. Methods: HCC827 and A549 cells were continuously grafted into erlotinib-containing culture medium to establish erlotinib-resistant cell lines. The expression of H19 and miR-615-3p was detected by qRT-PCR. The protein levels ofMMP2,MMP9,CD9,CD63 andATG7weremeasured by Western blot. Cell viability and proliferation were determined by Cell Counting Kit-8 (CCK-8) and3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazoliumbromide (MTT) assay, respectively. Migration and invasion were assessed by transwell assay. Xenograft tumor models were used to investigate the effect of H19 on erlotinib resistance in vivo. Online software and dual-luciferase reporter assaywere used to predicate the downstream targets and confirm the targeted relationships. Results: H19 was upregulated in erlotinib-resistant cells, and knockdown of H19 inhibited cell proliferation, migration and invasion in erlotinib-resistant cells. Extracellular H19 can be packaged into exosomes. Exosomes containing H19 induced erlotinib resistance of sensitive cells, while knockdown of H19 abolished this effect. miR-615-3p was a target of H19 and can bind to ATG7. Exosomal H19 affected erlotinib resistance of erlotinib-resistant NSCLC cells via targeting miR-615-3p to regulate ATG7 expression. In addition, the serum exosomal H19 was upregulated in patients with erlotinib resistance. Furthermore, downregulated H19 decreased the resistance of tumor cells to erlotinib in vivo. Conclusion: Our study demonstrated that exosomal H19 facilitated erlotinib resistance in NSCLC via miR-615-3p/ATG7 axis, which might provide a potential target for the diagnosis and treatment of NSCLC.
Proteomic pro ling reveals differentially expressed proteins associated with amylose accumulation during rice grain lling

Hengdong Zhang Hunan Agricultural University Jiana Chen Hunan Agricultural University Shuanglü Shah Hunan Agricultural University Fangbo Cao Hunan Agricultural University Guanghui Chen Hunan Agricultural University Yingbin Zou Hunan Agricultural University Min Huang Hunan Agricultural University Salah Fatouh Abou-Elwafa (  elwafa75@aun.edu.eg ) Assiut University Faculty of Agriculture https://orcid.org/0000-0002-9018-598X
A moment estimator for the index of an extreme-value distribution

On generalise l'estimateur bien connu de Hill de l'indice d'une fonction de reparatition avec queue de variation reguliere a une estimation de l'indice d'une loi de valeurs extremes. On demontre la convergence et la normalite asymptotique. On utilise l'estimateur pour certaines estimations comme celle d'une quantile elevee et d'un point d'extremite
Pathway In Vivo Cells through the Indirect Presentation Preferentially Activates Recipient CD4 The Male Minor Transplantation Antigen

To evaluate the priming and trafﬁcking of male Ag-reactive CD4 (cid:1) T cells in vivo, we developed an adoptive transfer model, using Marilyn (Mar) TCR transgenic T cells that are speciﬁc for the H-Y minor transplantation Ag plus I-A b . By manipulating donor and recipient strain combinations, we permitted the Mar CD4 (cid:1) T cells to respond to the H-Y Ag after processing and presentation by recipient APCs (indirect pathway), or to the male Ag as expressed on donor APCs (direct pathway). Mar CD4 (cid:1) T cells responding through the indirect pathway speciﬁcally proliferated and expressed activation markers between days 2 and 4 posttransplant, migrated to the graft 2–3 days before cessation of graft heartbeat, and were detected in close proximity to transplant-inﬁltrating recipient APCs. Intriguingly, adoptively transferred Mar T cells did not respond to male heart or skin grafts placed onto syngeneic MHC class II-deﬁcient female recipients, demonstrating that activation of Mar T cell preferentially occurs through cognate interactions with processed male Ag expressed on recipient APCs. The data highlight the potency of indirect processing and presentation pathways in vivo and underscore the importance of indirectly primed CD4 (cid:1) T cells as relevant participants in both the priming and effector phases of acute graft rejection. The Journal of Immunology, 2003, 171: 6510–6518.