Miracle-dz/UniFAR-FTUs huggingface dataset:
Cells Persist in T 1 D Pancreata Without Evidence of Ongoing b-Cell Turnover or Neogenesis

Results: Residual insulin-producing b cells were detected in some (but not all) T1D cases of varying disease duration. Several T1D pancreata had substantial numbers of b cells. Although b-cell proliferation was prominent early in life, it dramatically declined after infancy in both nondiabetic controls andT1D individuals. However,b-cell proliferationwasequivalent in control andT1Dpancreata. b-cell death (assessed by TUNEL) was extremely rare in control and T1D pancreata. Thus, b-cell turnover was not increased in T1D. Furthermore, we found no evidence of small islet/ductal neogenesis or a-cell to b-cell transdifferentiation in T1D pancreata, regardless of disease duration.
Anti-inflammatory effects of dexmedetomidine on human amnion-derived WISH cells

Background: To maintain the normal pregnancy, suppression of inflammatory signaling pathway is a crucial physiologic response. Dexmedetomidine has been used for labor analgesia or supplement of inadequate regional analgesia during delivery. And it has been reported that dexmedetomidine has an anti-inflammatory effect. In this study, we examined the influence of dexmedetomidine on the expression of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2) and inflammatory cytokines in lipopolysaccharide (LPS)-stimulated human amnion-derived WISH cells. In addition, we evaluated the association of mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathway in anti-inflammatory effect of dexmedetomidine. Methods: Human amnion-derived WISH cells were pretreated with various concentrations of dexmedetomidine (0.001-1 µg/ml) for 1 h and after then treated with LPS (1 µg/ml) for 24 h. MTT assay was conducted to evaluate the cytotoxicity. Nitric oxide (NO) production was analyzed using Griess-reaction microassay. RT-PCR was performed for analysis of mRNA expressions of COX-2, PGE2, tumor necrosis factor (TNF)-α and interlukin (IL)-1β. Protein expressions of COX-2, PGE2, p38 and NF-κB were analyzed by western blotting. Results: LPS and dexmedetomidine had no cytotoxic effect on WISH cells. There was no difference in NO production after dexmedetomidine pretreatment. The mRNA and protein expressions of COX-2 and PGE2 were decreased by dexmedetomidine pretreatment in LPS-treated WISH cells. Dexmedetomidine also attenuated the LPS-induced mRNA expression of TNF-α and IL-1β. The activation of p38 and NF-κB was suppressed by dexmedetomidine pretreatment in LPS-treated WISH cells. Conclusion: We demonstrated that dexmedetomidine pretreatment suppressed the expressions of inflammatory mediators increased by LPS. In addition, this study suggests that anti-inflammatory effect of dexmedetomidine on WISH cells was mediated by the inhibitions of p38 and NF-κB activation.
Changes in Math and Science Interest over School Transitions: Relations to Classroom Quality, Gender Stereotypes, and Efficacy

Significant declines in STEM ability beliefs and interest are often found during the transitions to middle school and high school. Girls generally report lower selfconcept and interest in STEM compared to boys. Some children remain interested in math and science over these transitions, but we know little about the school and social factors that contribute to their continued interest and if these factors differ by gender. This study examines changes in math and science self-efficacy and interest over two school transitions and the final two years in high school. It further examines if changes and gender discrepancies in math and science interest, can be accounted for by self-efficacy, classroom qualities and the gender stereotypical beliefs about the usefulness of math and science. Student in grades 5, 8, and 11 (N= 595) completed surveys on their math and science interest, self-efficacy, stereotypes, and classroom quality prior to transitioning to the next grade, and then one year post-transition. Although there were declines in interest and efficacy over school transitions they were not as substantial or pervasive compared to previous research. Gender differences were more apparent in high school than in earlier grades. Regression analyses indicated that changes in interest over time were explained by self-efficacy, classroom quality, and gender stereotype beliefs, although gender stereotypes were only predictive of science interest
The Need and Challenges for Ubiquitous Positioning, Navigation and Timing (PNT) Using Wi-Fi

This paper presents further results for indoor localization using Wi-Fi RSS (Received Signal Strength) measurements in a typical office environment from a one-week benchmarking measurement campaign carried out at The Ohio State University from the joint FIG/IAG Working Group on Multi-sensor Systems. Based on the paper presented at the FIG Working Week in Hanoi in 2019 significant progress in algorithm development for Wi-Fi localization is reported. Starting from an identification of the key points and challenges of ubiquitous pedestrian user localization in mass market LBS applications the novel probabilistic location fingerprinting approach demonstrates successful pedestrian user indoor localization on the room-level granularity. As for many applications, the determination of the room or a section of the building where the user is currently located is sufficient, this approach is a suitable solution for challenging indoor localization problems. Matching success rates of up to 97% for the localization of a user while walking along trajectories between different cells in an office building are achieved with the new approach
INCREASING POTENTIAL OF DISTRIBUTION CHANNELS FOR CREATIVE THAI HAND-WOVEN TEXTILE PRODUCTS IN THE DIGITAL ECONOMY

The research was to investigate the omni-channel distribution system for the weaving community enterprises. This research was qualitative, utilizing a case study approach. The results identify the limitations of selling creative products only through physical stores, which are unable to respond to customers’ purchasing behaviors and needs. Nevertheless, the online channel alone cannot communicate the delicacy of handmade woven products through digital media since they need to be touched and worn to be fully appreciated. This dichotomy led to the design and development of the first version of the system. The research encourages the weaving community enterprises to widen their market in order to be able to compete in digital economy. It provides valuable practical insights into local weaving community enterprises and their ability to market their creative products in the digital era. This research fills a gap in the literature relating to the customer journey and the integration of distribution channels and sheds light on the need for local weaving community enterprises to adapt to the current market conditions.
The Association of FLT3-ITD Gene Mutation with Bone Marrow Blast Cell Count, CD34, Cyclin D1, Bcl-xL and hENT1 Expression in Acute Myeloid Leukemia Patients

Background & Objective: FLT3-ITD has been recently used as a molecular prognostic marker for risk classification in acute myeloid leukemia (AML) therapy. In this study we aimed to investigate the association of FLT3-ITD gene mutation with bone marrow blast cell count, CD34 expression as malignant cell burden, cyclin D1 and Bcl-xL expressions as indexes of cell proliferation and anti-apoptosis and human equilibrative nucleoside transporter 1 (hENT1) expression as cytarabine transporter during AML treatment. Methods: We investigated FLT3-ITD mutations, bone marrow blast cell count, CD34, cyclin D1, Bcl-xL and hENT1 expression in bone marrow aspirates from 22 de novo AML patients in a cross sectional study. Results: FLT3-ITD mutations were observed in 5 out of 22 de novo AML patients (22.7%). Patient with FLT3-ITD mutations had higher blast cell counts (79.5% vs 56.1%, P=0.004). In patients with FLT3-ITD mutations, CD34 and cyclin D1 expressions were higher (MFI 328.80 vs 25.78, P=0.003 and MFI 74.51 vs 57.15 P=0.005) than the patients without mutations. hENT1 expression in AML with FLT3-ITD mutation was lower (MFI 29.64 versus 56.32, P=0.0000) than in mutation-free AML. There was no significant difference in Bcl-xL expression between patients with and without mutations (P=0.61). Conclusion: A significant association was found between FLT3-ITD gene mutations in AML patients with bone marrow blast cell count, CD34, cyclin D1 and hENT1 expressions, however no association was obtained with Bcl-xL expression. These findings support the role of such mutation in pathogenesis of AMLand its contribution in rearrangement of standard therapy with cytarabine in management of AML.
Rethinking complexity

This paper addresses the nature of complexity of recursion. We consider four asymmetries involving caps on recursion observed in previous experimental acquisition studies, which argue that complexity cannot be characterized exclusively in terms of the number of iterations of Merge. While recursion is essentially syntactic and allowed for by the minimalist toolkit via Merge, selection, and labeling or projection, the complexity of recursive outputs arises at the interface.
The Effect of Partial and Chronic Sleep Deprivation on Working Memory and Attention in Emergency Medicine Interns

Background: Sleep is an organized behavior that is repeated every day as a vital necessity based on the biological rhythm. Sleep deprivation is known as one of the major problems that can cause functional impairment in individuals. Therefore, it is expected that sleep deprivation in interns also causes problems in their performance. Objectives: According to the importance of cognitive health in health care workers, we decided to study the eﬀects of partial and chronic sleep deprivation on attention and working memory in the emergency medicine interns in Yazd University of Medical Sciences. Methods: Thenumberof 50emergencymedicineinternswererandomlyselectedandtheirdemographicinformationwasentered the data collection form. The subjects were examined before and after the one-month period of the shift work. Working memory and attention in participants were compared with the application of working memory and attention tests in 2-time points. Finally, the collected data were entered the SPSS software version 16 and statistical tests were performed subsequently. Results: The results showed that there is no signiﬁcant diﬀerence between the mean of direct and reverse auditory working mem-ory,directandreversevisualworkingmemory,aswellasthedividedattentionof participantsbeforeandaftertheone-monthperiod of the shift work, but there was a signiﬁcant diﬀerence between the average of selective attention of participants before and after the one-month period of the shift work (P value < 0.05). Also, this study showed that, regardless of the eﬀect of sleep deprivation, the mean of divided attention and working memory are diﬀerent between males and females. Conclusions: Accordingtotheresultsof thestudy,itcanbeconcludedthatthetypeof sleepdeprivationintheemergencymedicine interns only reduces the selective attention and this eﬀect was not dependent on the gender.
Regret and information at first price auctions: a study with brazilian decision-makers

Studies point out that the utility of the decision maker in the results depends on the profit. However, acting rationally in an auction environment can be difficult, and the reasons may be due to cognitive aspects such as regret. The "Winner's Regret" bias is characterized by the regret that the winner suffers for bidding too high compared to his opponent. The "Loser’s regret" comes from realizing that his very low bid made him lose. Therefore, the objective of this study was to investigate the effect of regret and information on first price auctions in Brazilian individuals and compare with studies conducted abroad, checking if there is a difference in bias amplitude. Initially, a literature review on behavioral operations, auctions and the effect of regret in auctions was performed. Regarding the methodology, the sample applied was non-probabilistic and for convenience. The experiment design had four treatments: Winner's Regret, Loser's Regret, Both and None, manipulated in a 4x1 experiment with college students. Regarding the winner's regret, the results were similar to studies abroad and in the hypothesis of the loser's regret the results were different.
DYNAMIC CAPABILITIES EROSION IN INDONESIA’S RETAIL INDUSTRY: CONSUMERS’ PERSPECTIVE ON MATAHARI DEPARTMENT STORE

This research was conducted to analyze the effect of dynamic capabilities erosion on firm’s survival according to consumers’ perspective, using sensing erosion, seizing erosion, and reconfiguring erosion as the independent variables (X) and firm survival as the dependent variable (Y). This research uses quantitative research methods with data processing using SPSS. Data collection was carried out by distributing questionnaires online through Google form to 500 student respondents who had visited Matahari Department Store in Indonesia. Sampling is done by purposive sampling technique. The questionnaires that qualify to be analyzed are 158 questionnaires. The result of data processing shows that the effect of the independent variable on the dependent variable is 40.3%. The results of this study is according to consumers’ perspective, sensing erosion, seizing erosion, and reconfiguring erosion affect firm survival.
New Artiopodan Arthropods from the Early Cambrian Emu Bay Shale Konservat-Lagerstätte of South Australia

Abstract The Emu Bay Shale Konservat-Lagerstätte (Cambrian Series 2, Stage 4) on Kangaroo Island, South Australia, is the source of two new non-biomineralized artiopodan arthropods. Squamacula buckorum n. sp. is the first record outside of China of a genus otherwise known only from its type species, S. clypeata, from the Chengjiang biota. The Australian species displays the long cephalic doublure and spiniform exopod setae that are apomorphic for this genus, provides new information on the alimentary tract and midgut glands (the latter preserved as three-dimensional, permineralized structures), and indicates interspecific variability in trunk segment numbers. The distribution of Squamacula strengthens the biogeographic connections between early Cambrian “Burgess Shale-type” biotas of Australia and South China. Australimicola spriggi n. gen. n. sp. represents a monotypic genus resolved in a cladistic analysis of Cambro-Ordovician artiopodans as most closely related to or within Conciliterga (a clade containing Helmetia, Kuamaia, Kwanyinaspis, Rhombicalvaria, Saperion, Skioldia, and Tegopelte). Compared with other members of this clade from Chengjiang and the Burgess Shale, the new genus is diagnosed by an elongate trunk with 23 thoracic tergites having spatulate pleural tips and a small pygidium possessing a single, elongate pair of pleural spines, with specimens also showing a hypostome attached to an anterior (or prehypostomal) sclerite, antennae, short endopods, an annulated alimentary tract, and a series of three-dimensional, permineralized midgut glands. An alternative relationship between Australimicola and the Early Ordovician–Early Devonian Cheloniellida explains the shared anterior flexure of trunk pleurae but forces dubious homologies in other characters, such as dorsally-articulated furcae versus spines.
Antidiabetic assays' based fractionation and characterization of Jamun (Syzygium cumini Skeels) fruits

Jamun (Syzygium cumini Skeels) fruits are well known for their anti-diabetic properties. The present study aimed at characterization of promising accessions for anti-diabetic and anti-oxidant metabolites in seeds and pulp. Among 7 accessions characterized, fruit pulp of CISH J-36 and CISH J-37 recorded high DDPH scavenging activity (anti-oxidant potential), phenol and flavonoid content. Fractionation of the methanol extracts by liquid partitioning yielded 3 fractions (ethyl acetate, butanol and water) which were evaluated based on bioactivity assays. α-Amylase inhibition was maximum with seed (methanol extracts) of all accessions, successive water extracts having anti-diabetic potential as demonstrated by the inhibition assay. Five fractions collected by liquid-liquid partition using ethyl acetate (EA), butanol and water showed varying levels of bioactivity, EA fraction with high DPPH scavenging activity and butanol fraction with high α-Amylase inhibition activity. Sixth fraction (Sc/EA/A6) had best bioactivity (aldose reductase assay: IC50 4.20μg/ml). The anti-oxidant and anti-diabetic potential based on DPPH and αAmylase inhibition assays are pioneering attempts to evaluate Jamun germplasm and its fruit parts for recovery of bioactive principles for development of novel phytomedicines.
A cartographic study of the phase space of the restricted three body problem

This work deals with numerical investigations of the phase space of the restricted three body model. The Sun-Jupiter-Asteroid system is considered and the fast Lyapunov indicator (FLI) is used as a tool to examine various types of orbits on which the infinitesimal mass can undergo. The FLI is computed on given grids of initial conditions and the obtained charts are analyzed. The chaotic zones and the libration regions associated with the mean motion resonances of low order are clearly distinguished. Their size is discussed as a function of the resonance order and the parameters entering into the perturbing function.
Microfinance Bank Lending Rate and Repayment Capability of Borrowers in Some Selected Microfinance Banks in Oyo State, Nigeria

The research investigated the lending rate and repayment capability of microfinance banks’ (MFBs) borrowers in Oyo State in the southwest, Nigeria with a case study of some selected microfinance banks. The researcher selected twenty microfinance banks through the use of random sampling technique from a population of fifty-three. The Cox regression was used for the analysis of data obtained from the primary source through the use of a questionnaire. It was found out that there is significant relationship between lending rate and repayment capability of borrowers with hazard ratio of 1.0000 and 1.00019 at 0.01% which implies that loan size, and lending rate do significantly contribute to the repayment capability hazard, indicating inability of the bank’s clients to meet up with their instalment payment. It was suggested that loan size should be based on client’s cash-flow and financial capability, and there should be consideration for re-negotiation of loan term to avoid outright loss of loan and interest.
Quantifying Domestic Violence in Times of Crisis

We propose a model that (i) provides an algorithm for measuring temporal variation in domestic violence incidence based on internet search activity and (ii) makes precise the conditions under which this measure yields less biased estimates of the domestic violence problem during periods of crisis than traditional, police-recorded crime measures. Analyzing the COVID-19 lockdown in Greater London, we find a 40 percent peak increase in our internet search-based domestic violence index, 7-8 times larger than the increase in police recorded crimes and much closer to the increase reported by victim support charities in relation to helpline calls.
IL-6 and CD8+ T cell counts combined are an early predictor of in-hospital mortality of patients with COVID-19

BACKGROUNDFatal cases of COVID-19 are increasing globally. We retrospectively investigated the potential of immunologic parameters as early predictors of COVID-19.METHODSA total of 1018 patients with confirmed COVID-19 were enrolled in our 2-center retrospective study. Clinical feature, laboratory test, immunological test, radiological findings, and outcomes data were collected. Univariate and multivariable logistic regression analyses were performed to evaluate factors associated with in-hospital mortality. Receiver operator characteristic (ROC) curves and survival curves were plotted to evaluate their clinical utility.RESULTSThe counts of all T lymphocyte subsets were markedly lower in nonsurvivors than in survivors, especially CD8+ T cells. Among all tested cytokines, IL-6 was elevated most significantly, with an upward trend of more than 10-fold. Using multivariate logistic regression analysis, IL-6 levels of more than 20 pg/mL and CD8+ T cell counts of less than 165 cells/µL were found to be associated with in-hospital mortality after adjusting for confounding factors. Groups with IL-6 levels of more than 20 pg/mL and CD8+ T cell counts of less than 165 cells/µL had a higher percentage of older and male patients as well as a higher proportion of patients with comorbidities, ventilation, intensive care unit admission, shock, and death. Furthermore, the receiver operating curve of the model combining IL-6 (>20 pg/mL) and CD8+ T cell counts (<165 cells/µL) displayed a more favorable discrimination than that of the CURB-65 score. The Hosmer-Lemeshow test showed a good fit of the model, with no statistical significance.CONCLUSIONIL-6 (>20 pg/mL) and CD8+ T cell counts (<165 cells/µL) are 2 reliable prognostic indicators that accurately stratify patients into risk categories and predict COVID-19 mortality.FundingThis work was supported by funding from the National Natural Science Foundation of China (no. 81772477 and 81201848).
Temporomandibular Disorders, Non-Carious Cervical Lesions and Implant Failures: is Occlusion Guilty or Innocent?

We are always looking for the cause of these failures to justify results that aren’t always predictable. Alternatively, everyone pivots and blames occlusion as the root cause of the innumerous failures and pathologies such as Temporomandibular Disorders (TMD), Non-Carious Cervical Lesions (NCCLs) and dental implant failures. In this literature review relevant published studies were searched for in PubMed, from 2015 to 2020. It was concluded that DTM and NCCLs are multifactorial diseases, of which occlusion is not a causative factor; in addition to the biological failures of dental implants. However, regarding the mechanical failures of dental implants, occlusion can be considered a causative factor.
HOCHSCHILD COHOMOLOGY OF BRAUER ALGEBRAS

Suppose B is an algebra with a stratifying ideal BeB generated by an idempotent e. We will establish long exact sequences relating the Hochschild cohomology groups of the three algebras B, B/BeB and eBe. This provides a common generalization of various known results, all of which extend Happel’s long exact sequence for one-point extensions. Applying one of these sequences to Hochschild cohomology algebras modulo the ideal generated by homogeneous nilpotent elements, we obtain, in some cases, that these algebras are finitely generated.