Miracle-dz/UniFAR-FTUs huggingface dataset:
Dark -Field Microscopic Analysis on the Blood of 1,006 Symptomatic Persons After Anti-COVID mRNA Injections from Pfizer/BioNtech or Moderna

The use of dark-field microscopic analysis of fresh peripheral blood on a slide was once widespread in medicine, allowing a first and immediate assessment of the state of health of the corpuscular components of the blood. In the present study we analyzed with a dark-field optical microscope the peripheral blood drop from 1,006 symptomatic subjects after inoculation with an mRNA injection (Pfizer/BioNTech or Moderna), starting from March 2021. There were 948 subjects (94% of the total sample) whose blood showed aggregation of erythrocytes and the presence of particles of various shapes and sizes of unclear origin one month after the mRNA inoculation. In 12 subjects, blood was examined with the same method before vaccination, showing a perfectly normal hematological distribution. The alterations found after the inoculation of the mRNA injections further reinforce the suspicion that the modifications were due to the so-called “vaccines” themselves. We report 4 clinical cases, chosen as representative of the entire case series. Further studies are needed to define the exact nature of the particles found in the blood and to identify possible solutions to the problems they are evidently causing.
An International Journal of Applied Mathematics and Computation (IJAMC)

In this paper, the modified extended tanh method is used to construct new exact traveling wave solutions of the (3+1)-dimensional Kadomtsev-Petviashvili equation. The modified extended tanh method is one of most direct and effective algebraic method for obtaining exact solutions of nonlinear partial differential equations. The method can be applied to nonintegrable equations as well as to integrable ones.
Production and evaluation of some extruded food products using spirulina algae

In this study, spirulina which is one of the blue-green algae rich in protein 61.57% and contains a high proportion of essential amino acids (38.81% of the protein) and a source of naturally rich in vitamins especially vitamin B complex such as vitamin B 12 (193 μg / 100 g) and folic acid (9.66 mg / 100 g), which helps the growth and nutrition of the child brain, also rich in calcium and iron it containing (1043.62 and 338.76 mg / 100 g, respectively) to protect against osteoporosis and blood diseases as well as a high percentage of natural fibers. So, the spirulina is useful and necessary for the growth of infants and very suitable for children, especially in the growth phase, the elderly and the visually appetite. It also, helps a lot in cases of general weakness, anemia and chronic constipation. Spirulina contain an selenium element (0.0488 mg/100 g) and many of the phytopigments such as chlorophyll and phycocyanin (1.472% and 14.18%), and those seen as a powerful antioxidant. It ensures the whole food and alkaline balance of the body. The spirulina used in the production of snack food by some addition percentages zero, 2.5, 5, 7.5, 10 and 12.5%. Data of sensory evaluation results showed that the adding spirulina by ratio 12.5% had lower score for most properties compared to other tested. The chemical analysis was done, the obtained data showed that the add spirulina a large role in increasing protein ratio and ash where the results were (9.43 - 18.11%) and (1.31 - 2.67%) for the samples the control sample and 10% spirulina. The physical properties measurement were done, such as density, the expansion rate, grain index, WSI and WAI, the results showed that the adding rate of spirulina was improvmant the physical properties of the snacks. It was safety study microbiology samples prepared by adding snack spirulina and all samples were microbiologically safe. Rheological properties were measured for snacks samples by using (Instron universal testing machine model 4301) for measuring textures, all texture parameters were improved and increased constants textures add spirulina and was at the same time economical cost and therefore can be produced for domestic use as well as can be exported abroad.
Exploring the Usage of the Mobile Phones by SMEs in the Achievement of Vision 2020 Goals

This research seeks to investigate the usage of mobile phones by the rural SMEs to achieve the vision2020 goals, with a specific focus on good governance, poverty alleviation and, health, education, human resource and empowerment. There is relatively little known about the use of mobile phones in achieving national socioeconomic development agendas. This research fills the gap by presenting mobile phones as the enablers of Vision2020 goals in Bangladesh. The findings from 32 interviewees suggest that mobile phones can assist the government of developing countries, and in particular the Bangladeshi government in achieving vision2020, by providing a distribution channel for good governance, poverty alleviation, health, education, human resource and empowerment programs. The findings of this study, the opportunities to use mobile phones for rural SMEs sustainability, as a platform for collaborative learning, as a tool for lifelong development for SMEs, are rarely addressed in prior studies. Since most of the prior studies approach mobile phones use from the consumer standpoint, this is one of the few papers that address the socioeconomic development opportunities for the rural SMEs. Furthermore, this research collected data from the SMEs to understand the development opportunities and also from the service providers, such as government officers, NGOs experts, university teachers, doctors and bankers, to provide more insights on the development mechanisms using mobile phones. Therefore, the outcomes and results of this research will be of potential value to the service providers in achieving Vision2020 goals in Bangladesh and in other developing countries.
Adverse event management in patients with advanced cancer receiving oral everolimus: focus on breast cancer

Background: Everolimus, an orally administered rapamycin analogue, inhibits the mammalian target of rapamycin (mTOR), a highly conserved intracellular serine – threonine kinase that is a central node in a network of signaling pathways controlling cellular metabolism, growth, survival, proliferation, angiogenesis, and immune function. Everolimus has demonstrated substantial clinical bene ﬁ t in randomized, controlled, phase III studies leading to approval for the treatment of advanced renal cell carcinoma, advanced neuroendocrine tumors of pancreatic origin, renal angiomyolipoma and subependymal giant-cell astrocytoma associated with tuberous sclerosis complex, as well as advanced hormone-receptor-positive (HR + ) and human epidermal growth factor receptor-2-negative advanced breast cancer. Materials and methods: We discuss clinically relevant everolimus-related adverse events from the phase III studies, including stomatitis, noninfectious pneumonitis, rash, selected metabolic abnormalities, and infections, with focus on appropriate clinical management of these events and speci ﬁ c considerations in patients with breast cancer. Results: The majority of adverse events experienced during everolimus therapy are of mild to moderate severity. The safety pro ﬁ le and protocols for toxicity management are well established. The class-effect adverse event pro ﬁ le observed with everolimus plus endocrine therapy in breast cancer is (as expected) distinct from that of endocrine therapy alone, but is similar to that observed with everolimus in other solid tumors. Information gained from the experience in other carcin-omas on prompt diagnosis and treatments to optimize drug exposure, treatment outcomes, and patients ’ quality of life also applies to the patient population with advanced breast cancer. Conclusions: As with all orally administered agents, education of both physicians and patients in the management of adverse events for patients receiving everolimus is critical to achieving optimal exposure and clinical bene ﬁ t. Active monitoring for early identi ﬁ cation of everolimus-related adverse events combined with aggressive and appropriate intervention should lead to a reduction in the severity and duration of the event.
Antioxidative response to coffee – depending on human Nrf2 genotype?

In a human intervention trial, a coffee, combining nature green coffee bean constituents and dark roast products was studied towards its potential to activate the Nrf2/ARE-pathway in PBLs. The study coffee was identified as a strong inducer of Nrf2 and downstream GST1A1 and UGT1A1 gene transcription. However, the response of the participants was found to depend on the respective genotype. The 651 SNP in the Nrf2 gene as well as the heterozygote 6/7 sequence in the UGT1A1 gene significantly down-regulated the susceptibility to respond to coffee, proposing the existing genotype to be critical for the response to the coffee.
Self-deception in the predictive mind: cognitive strategies and a challenge from motivation

ABSTRACT In this article, we show how the phenomenon of self-deception when adequately analyzed, can be incorporated into a predictive processing framework. We describe four strategies by which a subject may become self-deceived to account for typical cases of self-deception. We then argue that the four strategies can be modeled within this framework, under the assumption that a satisfying account of motivation is possible within predictive processing. Finally, we outline how we can ground this assumption by discussing how such a systematic model of motivation may be developed using the distinction between a world-model and a self-model.
Characterization of the Tritium Labeled Analog of L-Threo-beta-benzyloxyaspartate (TBOA) Binding to Glutamate Transporters Fast

L-Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Termination of glutamate receptor activation and maintenance of low extracellular glutamate concentrations are primarily achieved by glutamate transporters (excitatory amino acid transporters 1-5: EAATs1-5) located both on the nerve endings and the surrounding glial cells. In order to identify the physiological roles of each subtype, subtype selective EAAT ligands are required. In this study, we developed a binding assay system to characterize EAAT ligands for all EAAT subtypes. We recently synthesized novel analogs of threo - β -benzyloxyaspartate (TBOA) and reported that they blocked glutamate uptake by EAATs1-5 much more potently than TBOA. The strong inhibitory activity of the TBOA analogs suggested that they would be suitable to use as radioisotope labeled ligands, and we therefore synthesized a tritiated derivative of (2 S , 3 S )-3-{3-[4-ethylbenzoylamino]benzyloxy}aspartate ([ 3 H]ETB-TBOA). [ 3 H]ETB-TBOA showed significant high affinity specific binding to EAAT-transfected COS-1 cell membranes with each EAAT subtype. The Hill coefficient for the Na + -dependency of [ 3 H]ETB-TBOA binding revealed a single class of non-cooperative binding sites for Na + , suggesting that Na + binding in the ligand binding step is different from Na + binding in the substrate uptake process. The binding was displaced by known substrates and blockers. The rank order of inhibition by these compounds was consistent with previously reported glutamate uptake assay results. Thus, the [ 3 H]ETB-TBOA binding assay will be useful to screen novel EAAT ligands for all EAAT subtypes. For saturation experiments, binding of [ 3 H]ETB-TBOA was measured over concentrations range of 5-100 nM for EAAT1,2,4,5 and 10-300 nM for EAAT3. To generate a Na + concentration response curve, 20 nM [ 3 H]ETB-TBOA was used and the specific binding at each Na + concentration was normalized to the amount bound at 120 mM Na + (100%). The Hill coefficient was determined from the slope of a Hill plot of log[B/(B max - B)] as a function of log[Na + ]. Measurements [ 14 transfected Transfected COS-1 cells MDCK cells stably EAAT2 or EAAT3 were seeded in 96-well plates and cultured for 2 days. The subconfluent cells were washed two times with 300 µ L of modified PBS that contained 137 mM NaCl, 2.7 mM KCl, 8.1 mM Na 2 HPO 4 , 1.5 mM KH 2 PO 4 , 1 mM MgCl 2 , 1 mM CaCl 2 , and 10 mM D-glucose (pH 7.4) and preincubated in 300 µ L of the same buffer at 37 °C for 12 min. After aspiration of the cells were incubated with C]glutamate in of the modified in the of at various at To terminate uptake, cells were washed three times with cold Radioactivity was measured by scintillation counting (TopCount, PerkinElmer) in 100 µ L of Microscinti40 (PerkinElmer). Non-specific uptake was determined in the presence of 1 µ M TFB-TBOA. Specific uptake of [ 14 C]glutamate is presented relative to the control. All values displayed are the mean ± S.E. M. of at least three experiments.
OPTH_A_266123 2013..2023

*These authors contributed equally to this work Purpose: To assess attitudes of pre-clinical undergraduate medical students toward learning smartphone funduscopy (SF) and its appropriateness as a teaching tool. Patients and Methods: Second year medical students received instruction on direct ophthalmoscopy (DO) and SF; they were then paired with a peer and randomly assigned to perform DO or SF first. The SF technique involved freehand alignment of the axes of the smartphone camera with a condenser lens. Both techniques were done through a maximally dilated pupil. A questionnaire was completed to acquire data on baseline experience, performance of both examination techniques, attitudes, and appropriateness. Statistical significance testing and Bland-Altman analysis were used to determine differences between DO and SF, and a multivariable mixed regression model was fitted to identify any predictors for positive attitudes toward DO or SF. Results: One hundred thirty-seven (137) individuals completed the study. A similar proportion of students could identify the optic nerve, macula, and vessels using DO and SF. However, self-reported quality scores were higher for DO for the optic nerve (p = 0.006) and macula (p = 0.08). The mean (standard deviation) attempts to identify these major structures were 2.7 (SD 2.3) for DO and 4.5 (SD 2.9) for SF (p < 0.001). Attitudes of students were consistently more positive toward DO across the five questions assessed. A small subset of students had equally positive attitudes toward DO and SF. Improved quality scores were predictive of positive attitudes for both DO and SF. Ultimately, 24% of students preferred SF over DO. Conclusion: Among inexperienced examiners of the fundus through a dilated pupil, SF is a non-inferior technique to DO in identifying structures. Despite overall favorable attitudes towards the more familiar DO, those students who quickly learned the SF technique had similar satisfaction scores. Teaching SF should be considered in undergraduate medical education.
Contrôle ferroélectrique du couplage spin-orbite dans les dichalcogenides de métaux de transition Ferroelectric control of spin-orbit coupling in transition metal dichalcogenides

Context and main objectives of the project: Today’s electronics is based on the manipulation of the electron charge in semiconductors. Charge-based devices are getting to their intrinsic limits in terms of storage density and power consumption. Acting on the spin, another degree of freedom of the electron has been a vivid, central research topic for some years now and will lead to significant improvements in device performances [1]. Two fundamental bricks are required for a usable spintronic system. First, the material must have non-spin-degenerate electron bands, effectively separating up and down spin states (encoding). Second, an external action (current, stress, voltage, light) should be able to tailor the properties of these bands (write) and characterize its state (read). Manipulation of spin using electric current and light has already been demonstrated in solid state physics [2, 3]. However, the key to successful devices in spintronics lies in the electric control of the spin since voltage application is the easiest and more energy-friendly way to act on electronic chips [4, 5]. direct measurement of the electronic band structures via state-of-the-art photoemission techniques, feat nobody TMDCs/FE interfaces. Combination of different ferroelectric materials (BaTiO 3 , BiFeO 3 , (Pb,Zr)TiO 3 ) and TMDCs (MoS 2 , WS 2 , WSe 2 , MoTe 2 ) will permit a systematic study of the interface coupling and give quantitative values for the bands energy and momentum splitting as a function of the ferroelectric polarization magnitude and direction. Spin-resolved PES will confirm the spin-polarized nature of these bands.
Developing and Adopting Trust-aware Collaborative Prediction of QoS for Service-based Systems

—An application (service) can be composed of existing services. Generally, an appropriate service might be selected according to the predicted Quality of Service (QoS) values, and the most common approach for service selection is using collaborative ﬁltering for prediction. In this paper, we present a trust-aware QoS prediction method for service selection, which is inspired by trust relationships in social networks. We use direct and indirect similarities of opinion among users, each of which are combinations of belief, disbelief, and uncertainty. Then, we can derive similarities among users, select similar users, and predict the QoS value of a service. The experimental results show that the accuracy of QoS values determined using our method is better than that using other methods.
ALTERED LEVEL OF CONSCIOUSNESS: AETIOLOGY AND SHORT- TIME OUTCOME IN A TERTIARY HOSPITAL OF BANGLADESH

Altered level of consciousness is a very common medical emergency resulting in considerable mortality and morbidity. Accurate diagnosis and prompt management can reduce the complications to a great extent. There are various aetiologies of impaired consciousness including infective and metabolic causes as well as cerebro-vascular accidents. This hospital based prospective observational study described different clinical outcomes of the patients relating to specific aetiologies of the illness. Hundred patients of altered level of consciousness admitted in a tertiary hospital of Bangladesh were evaluated clinically and with relevant investigations. Their clinical outcomes in the form of mortality or residual morbidity within one month were determined on the basis of clinical, radiological and biochemical features. The mean age of the study patients was found 48.7 years with range from 19 to 92 years. Majority (58.0%) of the patients were male. CVD or stroke was identified as the commonest (39.0%)
Latrine-site use of small-clawed otters (Aonyx cinereus) in tropical rice fields

are known to serve as important habitats for aquatic and semi-aquatic wildlife. Owing to promotion of increased food production via agricultural modernization, changes in land use or farming practices have led to losses of aquatic and semi-aquatic organisms that use rice fields as foraging or refuge sites. The small-clawed otter ( Aonyx cinereus ) is an IUCN threatened species that uses rice fields as latrine sites and foraging habitats in South-east Asia. Thus, tropical rice field landscapes provide an opportunity to investigate how land-use and local environmental factors influence latrine-site use of this charismatic wildlife. Based on a year weekly field-survey and landscape analyses, we investigated latrine-site use by small-clawed otters in rice-field landscapes in West Sumatra, Indonesia. Using land-use and/or local environmental variables as predictors, we performed generalized linear model (GLM) or generalized linear mixed model (GLMM) analyses to explain the spatial patterns of latrine-site occurrence and spatial-temporal patterns of otter visitation to latrine sites. GLM analysis incorporating spatial patterns of latrine-site use revealed that a medium number of rice field huts was the single important factor explaining the occurrence of latrine sites in rice fields. Another GLM analysis incorporating spatial patterns of latrine-site use indicated that latrine sites that were adjacent to deep-water rice fields, distant from a settlement and close to river experienced the highest visitation by small-clawed otters. GLMM analysis incorporating temporal patterns of latrine-site use revealed that latrine sites that were adjacent to the
11 Genetics of Host Range in Lepidoptera

many versus few genes; genes on autosomes versus sex chromosomes; differences in the basis of interspecific versus intraspecific species. A variety of biochemical roles have been proposed for 0BPs, including the transport of odorants through sensillum lymph to ORPs and the deactivation of odorants following receptor activation (Park et al. 2000); whether 0BPs will prove to be involved in multiple processes in Lepidoptera remains to be seen. In Drosophila, recent work by Matsuo et al. (2007) suggests that 0BPs may be involved in host range. They examined the genetic basis of oviposition choice in D. sechellia, a specialist on Mormda citrifolia, which is toxic to the closely related D. melanogaster. Drosophila sechellia is preferentially attracted to M. cit rzjhlia fruit, while D. nielanogaster is deterred by its odor. Using targeted gene knockout and replacement, they replaced two D. melanogaster OBP genes (Ohl)57d and Obp57e) with the D. sechellia versions. In the resulting transformed flies, oviposition preference closely mir- rored that of D.sechellia. While such manipulations are not yet possible for any lepidopteran species, 0BPs and ORPs are attractive candidate genes for explaining differences in host plant use.
Antioxidant Potential and Element Contents of Wild Mushroom Tricholoma imbricatum

In this study, antioxidant and oxidant levels of wild mushroom Tricholoma imbricatum (F.) P. Kumm. were determined. In addition, the levels of Cu, Fe, Ni, Pb and Zn that they accumulated in their body were determined. In this context, antioxidant and oxidant status were determined using TAS and TOS kits. Element contents were measured using atomic absorption spectrometry. As a result of the studies, it was determined that TAS value of T. imbricatum was 3.474 ± 0.049, TOS value was 15.257 ± 0.117 and OSI value was 0.439 ± 0.003. Also, it has been determined that the mushroom could be a natural antioxidant source. In addition, it has been observed that the levels of elements accumulated within the fruiting body were at normal levels for wild mushrooms. As a result, it was thought that T. imbricatum could be used as a natural agent in pharmacological research because of its antioxidant potential.
USING ANTIOXIDANTS AND SOME ORGANIC NUTRIENTS TO IMPROVE FRUIT PRODUCTIVITY OF SWEET PEPPER UNDER HIGH TEMPERATURE STRESS CONDITION YIELD AND ITS COMPONENTS AND FRUIT QUALITY CHARACTERS

Two field experiments were conducted at El-Baramoon experimental farm of Horticultural Research Institute, Mansoura Governorate during 2006 and 2007 late summer seasons, on sweet pepper plants cv. California Wonder. The study aimed to investigate the effect of some antioxidants and nutrients in organic form to alleviate the adverse effects of high temperature stress and its related oxidative one; vitamin E-selenium (150 ppm vitamin E) – vitamin C (150 ppm) – zinc citrate (100 ppm Zn) – calcium citrate (2000 ppm Ca) were sprayed singly or in combinations. The obtained results showed that, all applied treatments ameliorated stress effects and significantly improved fruit yield (No. of fruits / plant, fruit average weight, fruit yield / plant and total fruit yield / fed.) and its physical (fruit length, fruit diameter and flesh thickness) and chemical quality(TSS %, vitamin C, total acidity % and dry matter %). The combination of zinc citrate + calcium citrate (100 ppm Zn + 2000 ppm Ca) or vitamin E-selenium + zinc citrate (150 ppm vitamin E + 100 ppm Zn) gave the highest significant results in both seasons, respectively.