Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-modal classification of cognitive load in a VR-based training system

Training systems are used in many industries, ranging from surgery to space missions to rehabilitation. Virtual Reality (VR) is a technology that has been incorporated as an effective tool in such training systems to simulate the environment, especially in situations where the training can’t take place in the actual environment. For a training environment and task to be effective, it must sufficiently challenge the trainee. One parameter that can be used to measure this is cognitive load (CL), which is defined as the amount of working memory used while performing a learning task. This parameter needs to be sufficiently high to maximize learning but not too high as to overload the trainee. However, the challenge is to detect this state using objective physiological measures, which can be collected during the entire task. This paper presents a study to classify CL using a combination of Electroencephalogram (EEG) and Electrodermal Activity (EDA) signals during a procedural VR training task. Thirty participants undertook a study where they built a designated model within a given time over multiple levels that were constructed to induce low to high CL. Features generated from the data were subject to feature selection (FS), which was undertaken using the Mutual Information (MI) technique. Binary classification models were developed using Support Vector Machines (SVM), Random Forest (RF), k-Nearest Neighbors (kNN), Extreme Gradient Boosting (Xgboost) and Multi-Layer Perceptrons (MLP). Results illustrated that the Xgboost classifier performed the best with an F1-score of $0.831 \pm 0.030$ and accuracy of $0.805 \pm 0.033. $ SHAP analysis of the features illustrated greater contributions from the frontal and occipital regions of the brain and frequency domain features from tonic skin conductance.
Low intra-crystalline closure temperatures of Cr-bearing spinels from the mantle xenoliths of the Middle Atlas Neogene-Quaternary Volcanic Field (Morocco): Mineralogical evidence of a cooler mantle beneath the West African Craton

Abstract The crystal chemistry of nine Cr-spinels from lherzolite and harzburgite xenoliths from the Middle Atlas Neogene-Quaternary Volcanic Field of Morocco have been studied by means of X-ray singlecrystal diffraction and electron microprobe analyses. Cell edges are usually within the range 8.13-8.14 Å, but there are three samples with longer a value, so that the whole analyzed series is within the range 8.1334(4)-8.2021(2) Å, while the oxygen positional parameter values are very similar ranging between 0.2626(1) and 0.2629(2) for all of them. The cation distribution shows that the crystal structure is ordered with almost all divalent cations in the tetrahedral site and trivalent cations in the octahedral site. The determined intracrystalline temperatures are in the range 550-750 °C that are the lowest values ever found for Cr-spinels from mantle xenoliths as these are usually higher than 730 °C. If we consider the behavior of some geotherms from literature, the determined temperatures are confined in a depth range of about 20-40 km. Lithospheric models for the studied area indicate that the lower crust reaches its deepest value in a range between 30 and 40 km. Consequently, we can assume that the studied xenoliths were emplaced at a “shallow” depth of about 20-30 km, just beneath the lower crust, where they were disrupted and brought to the surface from the ascending alkaline lavas. This assumption is consistent with the concomitant presence of some crustal xenoliths. It is important to notice that even in the case of a mantle xenoliths where all the silicates could be heavily altered, the presence of one single crystal of Cr-spinel and the study of its oxygen coordinates (u), inversion parameters (i), Cr content, and calculated closure temperatures can be used to validate the thermal history of the mantle xenoliths. The combined approach of structural data, intra- and inter-crystalline temperatures, and the literature geophysical data seems to be an interesting tool to assess the preexhumation history of the mantle xenoliths.
Team diversity and information use

Educational and national diversity are proposed to influence work teams' information use differently, with educational diversity mainly enhancing information use and national diversity invoking social categorization, thus hindering information use. As expected, increasing educational diversity positively influenced the range and depth of information use for all except the most diverse teams we studied, but negatively influenced information integration. In contrast to our expectations, national diversity had curvilinear relationships with the range, depth, and integration of information use. Both types of diversity provided information-processing benefits that outweighed the limitations associated with social categorization processes.
Antibiotic Resistance among Patients with Urinary Tract Infections in Kandahar, Afghanistan

Background: Antimicrobial resistance is a global public health threat. Highest burden of resistance is reported from low- and middle-income countries. Objectives: To investigate and report the current scenario of increased antibiotic resistance of uropathogens among symptomatic urinary tract infection patients in Kandahar, Afghanistan. Methods: From January 2018 to December 2021, this retrospective study was carried out at two main hospitals in Kandahar City, Afghanistan. Here, culture and sensitivity profiles of uropathogens were studied among symptomatic Bacteriuria in the presence of genitourinary symptoms (i.e., dysuria, suprapubic pain or tenderness, frequency, or urgency) (UTI) patients. Results: Among urine samples of 1589 patients, 1047 (65.9%) were culture positive and included in this study. Most of these patients (626/1047 [59.8%]) were females, with majority (818 [78.1%]) having age between 19 and 39 years. Gram-negative bacteria were the most prevalent (840/1047 [80.2%]), with E. coli (653/1047 [62.4%]) as the most common isolated uropathogen. Overall gram-negative bacteria had higher resistance against commonly used antibiotics of cotrimoxazole (62.8%), ciprofloxacin (56.0%), levofloxacin (47.5%), cefixime (44.5%), fosfomycin (41.5%), and even ceftriaxone (48.3%). Conclusions: Kandahar province has higher resistance rates against commonly used empirical antibiotics like norfloxacin, ciprofloxacin, levofloxacin, and cefixime. Nitrofurantoin should be used as the first-line antibiotic in treating UTI patients. Public health authorities should make strict regulations and policies to reduce irrational use, inappropriate prescription, and over-the-counter availability of antibiotics in Kandahar.
Integrated Transcriptomic and Metabolomic Analysis Reveals the Mechanism of Gibberellic Acid Regulates the Growth and Flavonoid Synthesis in Phellodendron chinense Schneid Seedlings

The phytohormone gibberellic acids (GAs) play a crucial role in the processes of growth, organ development, and secondary metabolism. However, the mechanism of exogenous GA3 regulating the growth and flavonoid synthesis in Phellodendron chinense Schneid (P. chinense Schneid) seedlings remains unclear. In this study, the physicochemical properties, gene expression level, and secondary metabolite of P. chinense Schneid seedlings under GA3 treatment were investigated. The results showed that GA3 significantly improved the plant height, ground diameter, fresh weight, chlorophyll content, soluble substance content, superoxide dismutase, and peroxidase activities. This was accompanied by elevated relative expression levels of Pc(S)-GA2ox, Pc(S)-DELLA, Pc(S)-SAUR50, Pc(S)-PsaD, Pc(S)-Psb 27, Pc(S)-PGK, Pc(S)-CER3, and Pc(S)-FBA unigenes. Conversely, a notable reduction was observed in the carotenoid content, catalase activity and the relative expression abundances of Pc(S)-KAO, Pc(S)-GID1/2, and Pc(S)-GH 3.6 unigenes in leaves of P. chinense Schneid seedlings (p < 0.05). Furthermore, GA3 evidently decreased the contents of pinocembrin, pinobanksin, isosakuranetin, naringin, naringenin, (−)-epicatechin, tricetin, luteolin, and vitexin belonged to flavonoid in stem bark of P. chinense Schneid seedlings (p < 0.05). These results indicated that exogenous GA3 promoted growth through improving chlorophyll content and gene expression in photosynthesis and phytohormone signal pathway and inhibited flavonoid synthesis in P. chinense Schneid seedlings.
Evolution of rhodopsin in flatfishes (Pleuronectiformes) is associated with depth and migratory behaviour

Visual signals are involved in many fitness-related tasks and are therefore essential for survival in many species. Aquatic organisms are ideal systems to study visual evolution, as the high diversity of spectral properties in aquatic environments generates great potential for adaptation to different light conditions. Flatfishes are an economically important group, with over 800 described species distributed globally, including halibut, flounder, sole and turbot. The diversity of flatfish species and wide array of environments they occupy provides an excellent opportunity to understand how this variation translates to molecular adaptation of vision genes. Using models of molecular evolution, we investigated how the light environments inhabited by different flatfish lineages have shaped evolution in the rhodopsin gene, which is responsible for mediating dim-light visual transduction. We found strong evidence for positive selection in rhodopsin, and this was correlated with both migratory behaviour and several fundamental aspects of habitat, including depth and freshwater/marine evolutionary transitions. We also identified several mutations that likely affect the wavelength of peak absorbance of rhodopsin, and outline how these shifts in absorbance correlate with response to the light spectrum present in different habitats. This is the first study of rhodopsin evolution in flatfishes that considers their extensive diversity, and our results highlight how ecologically-driven molecular adaptation has occurred across this group in response to transitions to novel light environments.
Clinical Characteristics, Risk Factors and Outcome of Pediatric Covid-19 in a Tertiary Care Institute, Northeast India

Background: COVID-19 disease in children is generally mild. Data on pediatric COVID-19 are limited. This study aimed to describe the clinical characteristics of COVID-19 disease in children and to identify the outcome of children admitted at a COVID-19 tertiary care institute, Northeast India. Material(s) and Method(s): Retrospective observational study on 181 children aged 0 to 14 years admitted in dedicated COVID care center between May 2021 to April 2022 are conducted. All the children with real time polymerase chain reaction SARS-CoV-2 positive children were assess for demographic, clinical characteristics, disease severity and various factors predicting outcome of COVID-19 disease. Variables were compared between children who were symptomatic with SpO2 <94% and asymptomatic/symptomatic with SpO2 >=94%. Result(s): Mean age was 5.0 years +/-4.149SD. Male (64.1%) were affected more than female.17. 68% children have comorbidities, 5.52% needed intensive care. Factors that remained associated with symptomatic children having SpO2 <94% were children younger than one year, female, urban region, complication, high mortality, comorbidities with cardiac disease, respiratory disease, hematological and chromosomal disease were significant. Mean duration of hospital stay was 6.9 days +/- 2.91SD and 2 (1.10%) children died. Conclusion(s): COVID-19 positive children with SpO2 <94% at hospitalization among symptomatic children has higher mortality than asymptomatic/ symptomatic children with SpO2 >=94%. Strict triaging for severity of COVID-19 positive children and early protocol-based treatment should be promoted by the health care professionals in all the health centers. Copyright © Necati Ozpinar. All rights reserved.
Cdc13 exhibits dynamic DNA strand exchange in the presence of telomeric DNA

Telomerase is the enzyme that lengthens telomeres and is tightly regulated by a variety of means to maintain genome integrity. Several DNA helicases function at telomeres, and we previously found that the Saccharomyces cerevisiae helicases Hrq1 and Pif1 directly regulate telomerase. To extend these findings, we are investigating the interplay between helicases, single-stranded DNA (ssDNA) binding proteins (ssBPs), and telomerase. The yeast ssBPs Cdc13 and RPA differentially affect Hrq1 and Pif1 helicase activity, and experiments to measure helicase disruption of Cdc13/ssDNA complexes instead revealed that Cdc13 can exchange between substrates. Although other ssBPs display dynamic binding, this was unexpected with Cdc13 due to the reported in vitro stability of the Cdc13/telomeric ssDNA complex. We found that the DNA exchange by Cdc13 occurs rapidly at physiological temperatures, requires telomeric repeat sequence DNA, and is affected by ssDNA length. Cdc13 truncations revealed that the low-affinity binding site (OB1), which is distal from the high-affinity binding site (OB3), is required for this intermolecular dynamic DNA exchange (DDE). We hypothesize that DDE by Cdc13 is the basis for how Cdc13 “moves” at telomeres to alternate between modes where it regulates telomerase activity and assists in telomere replication.
Ablation of Mitochondrial RCC1-L Induces Nigral Dopaminergic Neurodegeneration and Parkinsonian-like Motor Symptoms

Mitochondrial dysfunction has been linked to both idiopathic and familial forms of Parkinson’s disease (PD). We have previously identified RCC1-like (RCC1L) as a protein of the inner mitochondrial membrane important to mitochondrial fusion. Herein, to test whether deficits in RCC1L mitochondrial function might be involved in PD pathology, we have selectively ablated the Rcc1l gene in the dopaminergic (DA) neurons of mice. A PD-like phenotype resulted that includes progressive movement abnormalities, paralleled by progressive degeneration of the nigrostriatal tract. Experimental and control groups were examined at 2, 3-4, and 5-6 months of age. Animals were tested in the open field task to quantify anxiety, exploratory drive, locomotion, and immobility; and in the cylinder test to quantify rearing behavior. Beginning at 3-4 months, both female and male Rcc1l knockout mice show rigid muscles and resting tremor, kyphosis and a growth deficit compared with heterozygous or wild type littermate controls. Rcc1l knockout mice begin showing locomotor impairments at 3-4 months, which progress until 5-6 months of age, at which age the Rcc1l knockout mice die. The progressive motor impairments were associated with progressive and significantly reduced tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta (SNc), and dramatic loss of nigral DA projections in the striatum. Dystrophic spherical mitochondria are apparent in the soma of SNc neurons in Rcc1l knockout mice as early as 1.5-2.5 months of age and become progressively more pronounced until 5-6 months. Together, the results reveal the RCC1L protein to be essential to in vivo mitochondrial function in DA neurons. Further characterization of this mouse model will determine whether it represents a new model for in vivo study of PD, and the putative role of the human RCC1L gene as a risk factor that might increase PD occurrence and severity in humans.
Testing a 1-D analytical salt intrusion model and its predictive equations in Malaysian estuaries

Abstract Little is known about the salt intrusion behaviour in Malaysian estuaries. Study of salt intrusion generally requires large amounts of data, especially if 2-D or 3-D numerical models are used; thus, in data-poor environments, 1-D analytical models are more appropriate. A fully analytical 1-D salt intrusion model, which is simple to implement and requires minimal data, was tested in six previously unsurveyed Malaysian estuaries (Kurau, Perak, Bernam, Selangor, Muar and Endau). The required data can be collected during a single day of observations. Site measurements were conducted during the dry season (June–August 2012 and February–March 2013) near spring tide. Data on cross-sections (by echo-sounding), water levels (by pressure loggers) and salinity (by moving boat) were collected as model input. A good fit was demonstrated between the simulated and observed salinity distribution for all six estuaries. Additionally, the two calibration parameters (the Van der Burgh coefficient and the boundary condition for the dispersion) were compared with the existing predictive equations. Since gauging stations were only present in some nested catchments in the drainage basins, the river discharge had to be up-scaled to represent the total discharge contribution of the catchments. However, the correspondence between the calibration coefficients and the predictive equations was good, particularly in view of the uncertainty in the river discharge data used. This confirms that the predictive salt intrusion model is valid for the cases studied in Malaysia. The model provides a reliable, predictive tool, which the water authority of Malaysia can use for making decisions on water abstraction or dredging. Editor D. Koutsoyiannis; Associate editor A. Fiori
Description of a New Species of Plesiosaurus, in the Museum of the Bristol Institution

The animal about to be described in the following pages was discovered in the grey lias, which is largely quarried throughout Somersetshire for building-stone and other economic purposes. The remains of Enaliosaurians are distributed through the whole Liassic period, and it has been observed in the majority of cases as relates to the two genera Plesiosaurus and Ichthyosaurus, that specimens of the first-named genus are mostly found lying upon their backs, while the Ichthyosauri are generally lying upon their sides; but in a few instances the parts of the skeletons of both have become dislocated and detached from one another, not even retaining in any manner their relative position. In the first of these cases I imagine, that after the death of the animal, gases, evolved principally among the abdominal viscera, have been retained by means of the tough dermal covering, aided by the support of the sterno-costal arcs, and the body becoming gradually water-logged, was quietly deposited on the muddy bottom and afterwards silted up. The fact of the Ichthyosauri possessing a more fish-like form, the depth in their supero-inferior diameter being greater than their lateral width, accounts for their being so constantly found lying upon their sides; and the occasional dislocated condition to which I have alluded results from their tough integuments having held together until the interior of the body was so much macerated as to disunite the whole skeleton, which would then be similar to a number of loose bones held in a bag or sack.
Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience

Abstract Sustained low-efficiency dialysis (SLED) is usually performed over 6–12 h among hemodynamically unstable patients. Conduction of 4-h SLED may spare time and manpower during hospitalization. Therefore, we conducted a retrospective observational study to explore the appropriateness and clinical outcomes of 4-h SLED among critically ill patients admitted to our center from 1/06/2016 to 1/06/2020. Renal parameters including blood urea nitrogen, serum creatinine, sodium, phosphorus, potassium, and bicarbonate were determined on the day of dialysis before SLED and within 24 h after SLED, and clinical outcomes including, acute kidney injury (AKI) recovery, in-hospital mortality, 30-day mortality, 180-day mortality, and re-admission with AKI, were evaluated. Of the 304 patients included, 69.4% were male. The majority of patients were from the Middle East (65.8%), followed by 28.6% from Asia. Four-hour SLED resulted in a significant improvement in the renal parameters. Recovery from AKI was observed in 25.4%, in-hospital mortality rate was 48.7%, while the 30- and 180-day mortality outcomes were 3.2 and 9.6%, respectively, and re-admission with AKI was observed in 16.9%. Our findings suggest that 4-h SLED significantly improved renal parameters and was associated with favorable clinical outcomes in terms of survival and AKI recovery, suggesting possible utilization of SLED shorter than 6 h in the acute settings to preserve time and manpower for procedures.
Evolution of deep-water Tertiary sinuous channels offshore Angola (west Africa) and implications for reservoir architecture

Simple to complex, highly sinuous deep-water channels are common in the subsurface Tertiary off Angola, west Africa, and have been important exploration targets there in recent years. We discuss in this article three examples of these sinuous channels that are generally characterized by high-amplitude seismic reflection events, resulting from reservoir-prone lithologies. The planform characteristics of these channels--sinuosities and sinuous loop wavelengths--are similar to those of the fluvial channels; however, the planform combined with sectional seismic characteristics of the deep-water channels suggest that high sinuosities generally evolved through repeated channel aggradation and lateral migration. In detail, the influence of lateral migration vs. vertical aggradation in the evolution of the deep-water channel sinuosities varies from one channel to another and even along the length of a single channel or across a single sinuous loop. The lateral migrations may be continuous or discrete, separated in distance, and resolvable in seismic. Along some parts of the channels, very high initial sinuosities, not significantly affected by lateral migration, suggest that the initial sea-floor topography and gradients were a major factor in their development. In such cases, the channels essentially aggraded vertically. Thus, the modes of deep-water channel migration and sinuosity evolution are complex and different from those of fluvial channels that exhibit largely lateral (without much aggradational component) shifts within a meander loop. These differences are the result of unique hydrodynamic characteristics of the currents in these systems. The gross reservoir shapes in both the fluvial and deep-water channels are obviously dictated by their high sinuosities. The degree of lateral migration vs. vertical aggradation, however, determines the details of the lateral extent vs. vertical stacking of reservoir lithologies and their connectivities in deep-water sinuous channels. A fluvial, (Begin page 1374) point-bar-type continuity may be present in a part of a deep-water sinuous channel loop but is not expected to extend all across it.
A Climatology of the Southwest Vortex during 1979-2008

Abstract Using a new vortex detection and tracing method, a dataset of the Southwest Vortex (SWV) is established based on Japanese 25-year Reanalysis (JRA-25) reanalysis data during 1979–2008. The spatiotemporal features of the SWV are derived from the dataset. In comparison to other seasons, summer yields the least SWVs, but with the highest probability that they will migrate from their region of origin. SWVs mostly emerge in the southwest of the Sichuan Basin and the southeast of the Tibetan Plateau. Migratory SWVs mainly move along either an eastward or southeastward path. Detailed composite analysis of warm-season SWVs shows that the subtropical high is a key factor in determining the direction of migratory SWVs. Furthermore, the steering wind at 700 hPa dominates the moving direction of migratory SWVs. Potential stability diagnosed by pseudo-equivalent potential temperature θse is of certain significance for the evolution and movement of SWVs. On the other hand, migratory SWVs possess relatively greater strength than stationary SWVs, due to a stronger low-level jet with enhanced baroclinicity and moisture transport providing more energy to support the growth of SWVs along their paths of movement.