Miracle-dz/UniFAR-FTUs huggingface dataset:
Segmental Alterations of the Corpus Callosum in Progressive Supranuclear Palsy: A Multiparametric Magnetic Resonance Imaging Study

Background: The regional distribution of the widespread cerebral morphological alterations in progressive supranuclear palsy (PSP) is considered to include segmental parts of the corpus callosum (CC). Objective: The study was designed to investigate the regional white matter (WM) of the CC by T1 weighted magnetic resonance imaging (T1w MRI) data combined with diffusion tensor imaging (DTI) data in PSP patients, differentiated in the variants Richardson syndrome and PSP-parkinsonism, and to compare them with Parkinson’s Disease (PD) patients and healthy controls, in order to identify macro- and micro-structural alterations in vivo. Methods: MRI-based WM mapping was used to perform an operator-independent segmentation for the different CC segments in 66 PSP patients vs. 66 PD patients vs. 44 matched healthy controls. The segmentation was followed by both planimetric and texture analysis of the separated CC areas for the comparison of the three groups. Results were complemented by a DTI-based tract-of-interest analysis of the associated callosal tracts. Results: Significant alterations of the parameters entropy and homogeneity compared to controls were observed for PSP as well as for PD for the CC areas I, II, and III. The inhomogeneity in area II in the PSP cohort was the highest and differed significantly from PD. A combined score was defined as a potential marker for the different types of neurodegenerative parkinsonism; receiver operating characteristics (ROC) curves were calculated with areas under the curve values of 0.86 for PSP vs. controls, 0.72 for PD vs. controls, and 0.69 for PSP vs. PD, respectively. Conclusion: The multiparametric MRI texture and DTI analysis demonstrated extensive alterations of the frontal CC in neurodegenerative parkinsonism, whereas regional CC atrophy cannot be regarded as a constant neuroimaging feature of PSP. Specifically, the comparison PSP vs. PD revealed significant alterations in callosal area II. The combination of the texture and the DTI parameters might contribute as a neuroimaging marker for the assessment of the CC in PSP, including the differentiation vs. PD.
Protracted Neural Development of Dorsal Motor Systems During Handwriting and the Relation to Early Literacy Skills

Handwriting is a complex visual-motor skill that affects early reading development. A large body of work has demonstrated that handwriting is supported by a widespread neural system comprising ventral-temporal, parietal, and frontal motor regions in adults. Recent work has demonstrated that this neural system is largely established by 8 years of age, suggesting that the development of this system occurs in young children who are still learning to read and write. We made use of a novel MRI-compatible writing tablet that allowed us to measure brain activation in 5–8-year-old children during handwriting. We compared activation during handwriting in children and adults to provide information concerning the developmental trajectory of the neural system that supports handwriting. We found that parietal and frontal motor involvement during handwriting in children is different from adults, suggesting that the neural system that supports handwriting changes over the course of development. Furthermore, we found that parietal and frontal motor activation correlated with a literacy composite score in our child sample, suggesting that the individual differences in the dorsal response during handwriting are related to individual differences in emerging literacy skills. Our results suggest that components of the widespread neural system supporting handwriting develop at different rates and provide insight into the mechanisms underlying the contributions of handwriting to early literacy development.
Gut Microbiome Alterations in Patients With Carotid Atherosclerosis

Carotid atherosclerosis (CAS) is a reflection of systemic atherosclerosis and the main pathological processes of cardiovascular disease (CVD), namely, carotid intima–media thickening, carotid plaque formation, and carotid stenosis. Accumulating evidence indicates that the gut microbiota plays an important role in CVD and gut–brain disorders, but the associations of the composition and metabolites of the gut microbiome with CAS have not been studied comprehensively. We performed a gut microbiome genome-wide association study in 31 patients with CAS and 51 healthy controls using whole-genome shotgun sequencing. We found that several risk factors (waist circumference, body mass index, diastolic blood pressure, systolic blood pressure, fasting blood glucose, glycated hemoglobin A1c, total cholesterol, triglyceride, and low-density lipoprotein cholesterol) and inflammatory markers (white blood cell count and absolute value of neutrophils) were significantly higher in the CAS group than in the control group. In addition, 21 species and 142 pathways were enriched in the CAS group, and 10 species and 1 pathway were enriched in the control group. Specifically, Bacteroides eggerthii, Escherichia coli, and Klebsiella pneumoniae were the most abundant species in the CAS group, whereas Parabacteroides unclassified, Prevotella copri, Bacteroides sp 3_1_19, and Haemophilus parainfluenzae were the most abundant species in the control group. Finally, we found that most gut microbes and microbial pathways that were enriched in the CAS group had significant positive correlations with clinical characteristics, whereas the microbes and pathways enriched in healthy controls had significant negative correlations with clinical characteristics excluding high-density lipoprotein cholesterol. In addition, the associations between gut microbes and some microbial pathways (short-chain fatty acid, lipopolysaccharide, and menaquinol biosynthesis) were identified. Our results indicate the existence of a cyclic pathway that elevates the circulating concentrations of trimethylamine-N-oxide in patients with CAS but reduces its concentrations in healthy controls.
Impact of Pre-Revascularization and Post-Revascularization Cardiac Arrest on Survival Prognosis in Patients With Acute Myocardial Infarction and Following Emergency Percutaneous Coronary Intervention

Objectives: To evaluate the effects of occurrence and timing of sudden cardiac arrest (SCA) on survival in patients with acute myocardial infarction (AMI) who underwent emergency percutaneous coronary intervention (PCI). Methods: We analyzed 1,956 consecutive patients with AMI with emergency PCI from 2014 to 2018. Patients with cardiac arrest events were identified, and their medical records were reviewed. Results: Patients were divided into non-cardiac arrest group (NCA group, n = 1,724), pre-revascularization cardiac arrest (PRCA group, n = 175), and post-revascularization SCA (POCA group, n = 57) according to SCA timing. Compared to NCA group, PRCA group and POCA group presented with higher brain natriuretic polypeptide (BNP), more often Killip class 3/4, atrial fibrillation, and less often completed recovery of coronary artery perfusion (all p < 0.05). Both patients with PRCA and POCA showed increased 30-day all-cause mortality when compared to patients with NCA (8.0 and 70.2% vs. 2.9%, both p < 0.001). However, when compared to patients with NCA, patients with PRCA did not lead to higher mortality during long-term follow-up (median time 917 days) (16.3 vs. 18.6%, p = 0.441), whereas patients with POCA were associated with increased all-cause mortality (36.3 vs. 18.6%, p < 0.001). Multivariate analysis identified Killip class 3/4, atrial fibrillation, high maximum MB isoenzyme of creatine kianse, and high creatinine as predictive factors for POCA. In Cox regression analysis, POCA was found as a strong mortality-increase predictor (HR, 8.87; 95% CI, 2.26–34.72; p = 0.002) for long-term all-cause death. Conclusions: POCA appeared to be a strong life-threatening factor for 30-day and long-term all-cause mortality among patients with AMI who admitted alive and underwent emergency PCI. However, PRCA experience did not lead to a poorer long-term survival in patients with AMI surviving the first 30 days.
Structural and Functional Alterations of Gut Microbiota in Males With Hyperuricemia and High Levels of Liver Enzymes

Objective: To investigate the correlation between the structure and function alterations of gut microbiota and biochemical indicators in males with hyperuricemia (HUA) and high levels of liver enzymes, in order to provide new evidences and therapeutic targets for the clinical diagnosis and treatment of HUA. Methods: A total of 69 patients with HUA (HUA group) and 118 healthy controls were enrolled in this study. Their age, height, waist circumference, weight, and pressure were measured. The clinical parameters such as fasting plasma glucose (FBG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum uric acid (SUA), serum creatinine (Scr), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), white blood cell (WBC), platelet (PLT), and absolute value of neutrophils (NEUT) were examined. We used whole-genome shotgun sequencing technology and HUMAnN2 MetaCyc pathway database to detect the composition and pathways of the gut microbiota. The main statistical methods were student's t test, chi-square tests, and Wilcoxon rank sum test. The correlations among bacterial diversity, microbial pathways, and biochemical indicators were evaluated by the R function “cor.test” with spearman method. Results: The gut bacterial diversity in HUA group reduced significantly and the community of the microbiota was of significant difference between the two groups. The pathways that can produce 5-aminoimidazole ribonucleotide (PWY-6122, PWY-6277, and PWY-6121), aromatic amino acids, and chorismate (COMPLETE-ARO-PWY, ARO-PWY, and PWY-6163) were enriched in the HUA group; while the pathways that can produce short-chain fatty acids (SCFAs, such as CENTFERM-PWY and PWY-6590) and the gut microbiotas that can produce SCFAs (Roseburia hominis, Odoribacter splanchnicus, Ruminococcus callidus, Lachnospiraceae bacterium 3_1_46FAA, Bacteroides uniformis, Butyricimonas synergistica) and equol (Adlercreutzia equolifaciens) were enriched in healthy controls. Conclusion: The structure and function of the gut microbiota in males with HUA and high levels of liver enzymes have altered apparently. In-depth study of related mechanisms may provide new ideas for the treatment of HUA.
Associations Between CAMKK1 Polymorphism rs7214723 and the Prognosis of Patients With Lung Cancer

Background The 5-year survival rate of patients with lung cancer in China is less than 20% and predicting their prognosis is challenging. We investigated the association between a common non-synonymous single nucleotide polymorphism (SNP), rs7214723, in the Ca2+/calmodulin-dependent protein kinase kinase 1 (CAMKK1) gene and the prognosis of patients with lung cancer. Methods Genomic DNA was extracted from the blood samples of 839 patients with lung cancer, recruited from Changhai Hospital (n = 536) and Taizhou Institute of Health Sciences (n = 352), and genotyped using the SNPscan technique. The association between patient prognosis and the genotypic data for CAMKK1 was analyzed using a multivariate Cox proportional hazards model adjusted for multiple potential confounders. The CRISPR/Cas9 gene-editing system was used to introduce point mutations in the CAMKK1 rs7214723 of A549 and NCI-H358 cells. Subsequently, Cell proliferation and migration ability were assessed with the Cell Counting Kit-8 and scratch assay. The Annexin V-FITC apoptosis detection kit was used to detect cell apoptosis. Results The CAMKK1 rs7214723 recessive CC genotype conferred significantly better overall survival (CC vs. TT + TC: adjusted hazard ratio = 0.78, 95% confidence interval [CI], 0.61-1.00, P = 0.049) than the TT + TC genotypes. Stratified analysis showed that the CAMKK1 rs7214723 CC genotype and recessive CC genotype conferred a significantly decreased risk of death in patients who were male, had a smoking history, or had stage III + IV cancer, compared with the TT and TT + TC genotypes. Relative to the TT + TC genotypes, the rs7214723 recessive CC genotype was also associated with a decreased risk of death in patients aged < 60 years (CC vs. TT + TC: adjusted hazard ratio = 0.59, 95% CI, 0.37-0.93, P = 0.024) and patients with squamous cell carcinoma (CC vs. TT + TC: adjusted hazard ratio = 0.65, 95% CI, 0.44-0.98, P = 0.038). Remarkably, CRISPR/Cas9-guided single nucleotide editing demonstrated that CAMKK1 rs7214723 T > C mutation significantly inhibits cell proliferation and migration and promotes cell apoptosis. Conclusions CAMKK1 SNP rs7214723 may be a significant prognostic factor for the risk of death among patients with lung cancer.
Reliability of mesa and planar InGaAs PIN photodiodes

InGaAs planar-structure PIN photodiodes fabricated from MOVPE material have been demonstrated to have outstanding reliability. The predicted random failure rate at 20 degrees C is less than 0.3 FITs, and the mean time to failure is estimated to be 10/sup 11/ hours at 20 degrees C. By contrast, the reliability of mesa-structure photodiodes is unacceptable because of an instability of the dark current. A similar kind of instability has been observed in commercially available mesa photodiodes. Extensive life testing of planar-structure and mesa-structure PINs made by several manufacturers shows that the reliability of mesa-structure PINs is inferior in all cases. < >
Exosomal lncRNA UCA1 Derived From Pancreatic Stellate Cells Promotes Gemcitabine Resistance in Pancreatic Cancer via the SOCS3/EZH2 Axis

Objective Pancreatic cancer is associated with poor prognosis and dismal survival rates. This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by pancreatic stellate cells (PSCs) in Gemcitabine (Gem) resistance of pancreatic cancer under hypoxia, which involves the methylation of SOCS3 and EZH2 recruitment. Methods The exosomes were isolated from PSCs and hypoxic PSCs (HPSCs), and co-cultured with pancreatic cancer cells transduced with manipulated lncRNA UCA1, EZH2, and SOCS3. The interaction among lncRNA UCA1, EZH2, and SOCS3 was characterized by RIP and ChIP assays. Next, MTT assay, flow cytometry and TUNEL staining and Transwell assay were used to detect cell viability, apoptosis, invasion, and migration. Gem-resistant pancreatic cancer cell line (GemMIA-R3) was established, which was applied in a mouse xenograft model of pancreatic cancer, with MTT assay to determine Gem sensitivity. Results LncRNA UCA1 was highly expressed, while SOCS3 was poorly expressed in pancreatic cancer tissues. Hypoxia induced activation of PSCs and promoted release of exosomes. LncRNA UCA1 delivered by hypoxic PSC-derived exosomes (HPSC-EXO) regulated histone methylation level in SOCS3 gene region through recruitment of EZH2. In vitro and in vivo experimental results confirmed that lncRNA UCA1-loaded HPSC-EXO promoted malignant phenotypes, inhibited apoptosis, and promoted Gem resistance of pancreatic cancer cells as well as tumorigenesis in mice. Conclusion Under hypoxic conditions, exosomes secreted by hypoxia-induced PSCs deliver lncRNA UCA1 into pancreatic cancer cells, where lncRNA UCA1 recruits EZH2 and regulates histone methylation level in SOCS3 gene region, thereby augmenting pancreatic cancer resistance to Gem.
Reducing Crown Fire Hazard in Fire-Adapted Forests of New Mexico

Analysis of FIA data for New Mexico shows that 2.4 million acres of pon- derosa pine and dry mixed conifer forests rate high for fire hazard. A restoration treatment designed to address altered ecological conditions in these forests increased average crowning index (i.e., the wind speed necessary to maintain a crown fire) by 50 mph, compared to only 23 mph for a thin-from-below approach designed to reduce hazard. After we projected treated stands forward 30 years, only one-eighth of the acres receiving the thin-from-below treatment remained low hazard, com- pared to over half receiving the restoration treatment. ecent wildfires provide harsh testimony to the hazardous forest conditions that exist over large areas of New Mexico. The fires of 2000 are especially notable, not just in terms of acres burned, but particularly because of the significant damage to property and associated threats to people. There is now both the public support and political will for major initiatives to address this regional concern (Western Governors' Association 2001). For example, tens of millions of dollars have been distributed through the National Fire Plan, much of it dedicated to reducing hazardous fuels. How- ever, planning to address fire hazard at a strategic level requires understanding the forest conditions most vulnerable to fire and the effectiveness of alterna- tive hazard reduction treatments. Absence of a detailed, systematic, and uniform forest inventory for all acres and ownerships has heretofore precluded a comprehensive analysis of fire haz- ard in New Mexico. However, recent availability of Forest Inventory and Analysis (FIA) data, which are collected using consistent inventory protocols across all ownerships, made possible this strategic assessment of fire hazard at a statewide level. Objectives
Bent Hammer Handles: Performance and Preference

Sixty male students drove 10 nails with each of three hammers (0° bend, 10° bend and 15° bend). Handle angle did not significantly affect the depth the nails were driven, or the angle of the nail in the left-right direction. The mean front-to-back nail angle of . 3° for the 0° bend handle was significantly different from the −1.1° for the 10° handle and the −1.2° for the 15° handle. There was a significant preference for the 10° handle; the vote of 121% for the 10° handle was significantly higher than the 100% for the 0° handle and the 97% for the 15° handle.
Robust adaptive finite time control for spacecraft global attitude tracking maneuvers

This paper investigates spacecraft attitude control problem to achieve global fast tracking maneuvers. The concept of state-space form is initially introduced into spacecraft attitude dynamics and kinematics based on the unit quaternion, and then robust finite-time controllers are proposed based on geometric homogeneity and integral sliding mode. Furthermore, gain adaptation laws are employed and developed to eliminate the requirement of boundaries with respect to the lumped uncertainties, while there is no overestimation of the gains. Moreover, global finite-time controllers are designed to get across the singular point caused by the unit quaternion. Finally, simulations are presented to illustrate the effectiveness of the control strategies.
normalising power and engaged narrative methodology: refugee women, the forgotten category in the public discourse

Since the beginning of the 21st century, the discourse of othering of non-Western migrants has been growing in many European societies. And since 2015, refugees have become a quite visible component in this discourse. Although, for decades, the dominant image of refugees has been constructed as people ‘at risk’, new competing images of refugee men ‘as risk’ have recently gained ground. For refugee women, however, the image of being victims and ‘at risk’ still prevails. This shows a strong underlying gendered logic of feminine vulnerability and masculine threat. In this article, I show how these images are situated within the dominant Dutch discourse of migration with taken-for-granted taxonomies of the self and the other. Specific in this normalised discourse for refugee women is that their agency is either ignored or their possible position as activists is not acknowledged to exist. Using examples from two studies in which my research team engaged with the method of narrative engaged research, I show the importance of this particular narrative method in unsettling the normalising power of othering. The theoretical argument of this article engages with ongoing discussions on power and agency. It argues that, when the power of exclusion works through repetition and is manifested in the daily normalisation of actions, agency needs to provide an alternative in the same fluid manner. Narratives in dialogue provide an illuminating angle for discussing this specific kind of agency, as I will show through some examples from research.
Characterization of microstrip meanders in PCB interconnects

Meandering traces are often used to increase delay times in printed circuit board (PCB) interconnects. An accurate analysis of meanders in today's high speed digital circuits needs to take into account a number of different effects, including near field coupling between the turns of the meander and reflections at the line discontinuities. These effects have a significant impact on the delay and waveshape of the propagated signal. In this paper we analyze microstrip meander structures using a finite difference time domain (FDTD) based full wave method and a quasi-static technique. Signal propagation through meanders with different trace separations is examined. Shortcomings of the quasi-static approach are pointed out. Simple design guidelines are given.
In-situ stress and warpage measurements to investigate reliability of flip-chip on board assembly without underfill

Current printed wiring boards (PWBs) are all organic, the most common being epoxy-glass laminate FR-4 due to its cost effectiveness and overall perfonnance. However, for highdensity wiring (HDW) and assembly of flip-chips directly to the substrate without the use of underfill, substrate materials with low CTE and high elastic modulus are needed. Novel low CTE-high stiffness organic and inorganic hoards have been evaluated for flip-chip on board technology without the use of underfill. Standard liquid-liquid thermal shock tests were carried out on test vehicles with different board materials and failure modes were characterized. In-situ warpage and stress measurements were made to analyze the observed failure modes and to set guidelines for optimal board material selection. The effect of interlayer dielectric thickness on the package reliability has also been studied. The reliability test results are in accordance with the inferences from the in-situ warpage and stress measurements and it can be concluded that along with low CTE, high modulus is an inevitable substrate property requirement for flip-chip reliability without underfill in next-generation packages. This paper also presents Photostimulated Luminescence Spectroscopy (PSLS) and Raman Spectroscopy as non-destructive and direct techniques for the in-situ and residual stress measurement in microsystems and thus a powerful means for reliability assessment. Experimental results have also been supported by finite element models and analytical solutions.
Site Response Studies for Purpose of Revising NEHRP Seismic Provisions

A strong motion database was compiled for California earthquakes of surfacewave magnitudes, M s ≥ 6, occurring from 1933 through 1992. The database consisted of horizontal peak ground acceleration and 5 percent damped response spectra of accelerograms recorded on four different local geologies: rock (class A), soft rock or stiff soil (class B), medium stiff soil (class C), and soft soil (class D). The results of analyses of the database within each of these site classes were used to derive a set of site-dependent spectral amplification factors for oscillator periods between 0.1 and 4.0 sec and ground acceleration levels between 0.1 and 0.4 g. The amplification factors at 0.3 and 1.0 sec periods (designated as F a and F v , respectively) are generally within 20 percent of those recommended during the 1992 Site Response Workshop conducted by the National Center for Earthquake Engineering Research (NCEER). The F a and F v values recommended from our study and those from the NCEER workshop are intended for use by code committees making future revisions to the National Earthquake Hazard Reduction Program (NEHRP) seismic provisions and the Uniform Building Code.