Miracle-dz/UniFAR-FTUs huggingface dataset:
A COMPARATIVE STUDY ON THE RELATION BETWEEN HEPATIC ENCEPHALOPATHY AND HELICOBACTER PYLORI SEROPOSITIVITY AT NISHTER HOSPITAL MULTAN

: Objective: There is a shortage of availablity of awareness and knowledge on the incidence of (H. Pylori) Helicobacter pylori and its contribution to biliary tract disease incidence and liver pathology in human. We aimed at the assessment of the possible correlation between hepatic encephalopathy and seropositivity of the H. Pylori. Methodology: This research was held on cirrhotic patients having HE (Hepatic Encephalopathy), cirrhotic patients who do not have HE incidence and control group that included healthy patients. The serological assessment was carried out in all the patients in order to determine the classification of IgG antibodies to Helicobacter Pylori on the basis of the ELISA method. Results: Our outcomes reported that the presence of seropositivity of H. pylori was shown in eighty-eight percent of the patients with the incidence of HE; whereas, among patients, without HE and healthy controls it was respectively 86% and 66%. Conclusion: In the light of this research outcomes the element of seropositivity of H. Pylori seropositivity rate in cirrhotic patients having HE or without the incidence of HE was reported high in the healthy control group participants; whereas, the seropositivity of the H. Pylori was non-significant in the cirrhotic patients with the incidence of HE and also without HE incidence. Ammonia, Peptic Ulcer Disease, Bismuth, Palmar Erythema.
Impact of Personal Digital Devices Usage on Academic Impact of Personal Digital Devices Usage on Academic Performance of University Students in Pakistan Performance of University Students in Pakistan

This study aims to determine the impact of using personal digital devices (PDDs) on university student s’ academic performance. A survey-based questionnaire was developed and used to collect data from 240 Masters students of final semester (16-years of education) enrolled in the Faculty of Economics and Management Sciences, University of the Punjab, Lahore selected by proportional stratified sampling technique. The study concluded that the smart phones, mobile phones, laptops were frequently used PDDs by the students for the academic purposes. Students used PDDs for using social networks like Facebook, WhatsApp, Twitter, etc. in order to stay in touch with their classmates regarding their academic needs. It was found that using PDDs helped them improve their English language skills and PDDs also helped in their learning process hence improving their classroom performance. However, the use of PDDs also would divert students’ attention in class room. The use of PDDs facilitated students in their academic achievements and class room performance by improving the writing skills, their CGPAs/ Grades, and clearing their concepts. It would help the university management play an important role in encouraging their students to use their PDDs positively so they could improve their academic performance and learning.
University of Birmingham Achievement goals and motivational responses in tennis: Does the context matter?

Objectives: This study examined: (a) whether athletes’ goal orientations differ across training and competition; (b) whether goal orientations predict effort, enjoyment, and psychological skill use differently in training and competition; and (c) whether goal orientations predict perceived improvement in training and perceived performance in competition. Method: Participants were 116 competitive tennis players (mean age = 19.99, SD = 5.82), who completed questionnaires measuring goal orientations, effort, enjoyment, and psychological skill use in training and competition, perceived improvement in training, and perceived performance in competition. Results: Dependent t -tests revealed that athletes reported higher task orientation in training than in competition and higher ego orientation in competition than in training, while Pearson product-moment correlations revealed a high cross-contextual consistency for both task and ego goal orientations between training and competition. Regression analyses indicated that task orientation predicted positively effort, enjoyment, self-talk, and goal setting in both contexts, perceived improvement in training, and perceived performance in competition. An interaction effect also emerged whereby ego orientation predicted positively effort in competition only when task orientation was low or average. Conclusions: The findings suggest that goal orientations may differ between training and competition; task orientation is the goal that should be promoted in both contexts; and the context may affect the relationship between goal orientations and effort, enjoyment, and goal setting.
A Behavioral Modification Program for the Development of Critical Thinking on Heterosexual Relationships Among Early Adolescents

This mixed methods research aimed to study the critical thinking on Heterosexual Relationship of young adolescents in order to develop a behavioral modification program of critical thinking on heterosexual relationship among early adolescents and to examine the effects of the behavioral modification program of critical thinking on heterosexual relationships among early adolescents. This study was divided into two phases. The first phase had thirteen people involved and the second phase had forty participants who were qualified to join the study. The results of the study were as follow: the results of the definition of critical thinking on heterosexual relationships behavior was reflective thinking on a good future b efore engaging in heterosexual activities. Furthermore, this findings showed that there were four factors of critical thinking on heterosexual relationships separated into two internal conditions: attitude toward heterosexual relationship, and self-control; two external conditions: parents providing reason for education, and learning from role models. The results of the behavioral modification program in the second phase was that after participating in the program, the students who participated in the program had higher level of critical thinking on heterosexual relationship behavior than students who did not participated in the program significantly at . 05 level of confidence. The program might be useful for developing the critical thinking on heterosexual relationships. However, the author also suggested that the results of the behavioral modification program in this study is based on the skills in Thai reading and writing. Thus, skills in Thai reading and writing of the participants should be taken to considerations.
Medical Hypotheses Iron therapy as treatment of anemia: A potentially detrimental and hazardous strategy in colorectal cancer patients

In colorectal cancer patients, iron therapy, and especially intravenous iron therapy, is increasingly used to treat anemia and reduce the use of blood transfusions. However, iron has also been shown to be an essential nutrient for rapidly proliferating tissues and cells. In this respect, anemia of in ﬂ ammation, characterized by limited duodenal iron uptake and sequestration of iron into the reticuloendothelial system, might be regarded as a potentially e ﬀ ective defense strategy of the human body against tumor growth. We therefore hypothesize that iron therapy, by supporting colorectal tumor growth and increasing the metastatic potential, may worsen tumor prognosis in colorectal cancer patients. This hypothesis is particularly supported for colorectal cancer by la- boratory, epidemiological and animal studies, demonstrating the role of iron in all aspects of tumor development growth. Compared to non-malignant colon cells, tumor cells di ﬀ er in the levels and activity of many iron import and export proteins, resulting in an increase in intracellular iron level and enhanced proliferation. In addition, it is demonstrated that iron is able to amplify Wnt signaling in tumors with Apc mutation, a critical mutation in the development of colorectal cancer. If our hypothesis is to be con ﬁ rmed, current practice of iron administration, as treatment for anemia and as replacement of blood transfusions, can be hazardous and should be completely reconsidered.
EVALUATING ZERO-INFLATED AND HURDLE POISSON SPECIFICATIONS

his paper examines two alternative specifications for estimating event count models in which the data generating T process results in a larger number of zero counts than would be expected under standard distributional assumptions. I compare King’s "hurdle" event count model and Greene’s "zero-inflated" Poisson model, using data on Congressional responses to Supreme Court decisions from 1979 to 1988. I show that each of these models is a special case of a more general dual regime data generating process which results in extra-Poisson zero counts. Furthermore, because this data generating process can produce overdispersion in its own right, these models are also shown to be related to "variance function" negative binomial specifications. The underlying correspondence between these models leads to similar results in estimating and interpreting them in practice.
Identification of G1 Kinase Activity for cdk6, a Novel Cyclin D Partner

A family of vertebrate cdc2-related kinases has been identified, and these kinases are candidates for roles in cell cycle regulation. Here, we show that the human PLSTIRE gene product is a novel cyclin-dependent kinase, cdk6. The cdk6 kinase is associated with cyclins DI, D2, and D3 in lysates of human cells and is activated by coexpression with D-type cyclins in Sf9 insect cells. Furthermore, we demonstrate that endogenous cdk6 from human cell extracts is an active kinase which can phosphorylate pRB, the product of the retinoblastoma tumor suppressor gene. The activation of cdk6 kinase occurs during mid-G, in phytohemagglutinin-stimulated T cells, well prior to the activation of cdk2 kinase. This timing suggests that cdk6, and by analogy its homolog cdk4, links growth factor stimulation with the onset of cell cycle progression.
Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in In ﬂ ammatory Bowel Disease

Background: In ﬂ ammation results in signi ﬁ cant shifts in tissue metabolism. Recent studies indicate that in ﬂ ammation and hypoxia occur concomitantly. We examined whether circulating and tissue markers of hypoxia could serve as surrogate indicators of disease severity in adult and pediatric patients with in ﬂ ammatory bowel disease (IBD). Methods: Serum and colonic biopsies were obtained from pediatric subjects with active IBD colitis and adult subjects with active and inactive ulcerative colitis, along with healthy non-colitis controls of all ages. Disease activity was evaluated by endoscopy and histopathol-ogy. Levels of serum hypoxia markers (macrophage in ﬂ ammatory protein-3 α [MIP-3 α ], vascular endothelial growth factor [VEGF], and erythropoietin [EPO]) were measured. Results: Children with active IBD colitis had higher levels of serum MIP-3 α and VEGF compared to non-colitis controls (p<0.01 and p<0.05, respectively). In adult subjects with endoscopically active ulcerative colitis, serum MIP-3 α and EPO were signi ﬁ cantly elevated compared to non-colitis controls (both p<0.01). In parallel, analysis of colon tissue MIP-3 α mRNA and protein in pediatric subjects revealed increased expression in those with IBD colitis compared to controls (p<0.05 and p<0.01 for mRNA and protein, respectively). Serum MIP-3 α and VEGF signi ﬁ cantly increased with histology grade. Conclusion: Peripheral blood hypoxia markers may be useful indicators of disease activity for pediatric and adult IBD patients.
VivoChemokine/Chemokine Receptor Function In Allograft Rejection: Tissue Specificity of Differential Role of CCR2 in Islet and Heart

Chemokines have a pivotal role in the mobilization and activation of speciﬁc leukocyte subsets in acute allograft rejection. However, the role of speciﬁc chemokines and chemokine receptors in islet allograft rejection has not been fully elucidated. We now show that islet allograft rejection is associated with a steady increase in intragraft expression of the chemokines CCL8 (monocyte chemoattractant protein-2), CCL9 (monocyte chemoattractant protein-5), CCL5 (RANTES), CXCL-10 (IFN- (cid:1) -inducible protein-10), and CXCL9 (monokine induced by IFN- (cid:1) ) and their corresponding chemokine receptors CCR2, CCR5, CCR1, and CXCR3. Because CCR2 was found to be highly induced, we tested the speciﬁc role of CCR2 in islet allograft rejection by transplanting fully MHC mismatched islets from BALB/c mice into C57BL/6 wild-type (WT) and CCR2-deﬁcient mice (CCR2 (cid:2) / (cid:2) ). A signiﬁcant prolongation of islet allograft survival was noted in CCR2 (cid:2) / (cid:2) recipients, with median survival time of 24 and 12 days for CCR2 (cid:2) / (cid:2) and WT recipients, respectively ( p < 0.0001). This was associated with reduction in alloreactive of role for CCR2 in early islet allograft rejection highlights the tissue speciﬁcity of the chemokine/chemokine system in vivo in regulating allograft rejection. The Journal of Immunology, 2004, 172: 767–775.
and Encephalitis Driven Brain Lateral Ventricle Enlargement - Pathway Are Required To Counter HSV-1 Microglia and a Functional Type I IFN

HSV-1 is the leading cause of sporadic viral encephalitis, with mortality rates approaching 30% despite treatment with the antiviral drug of choice, acyclovir. Permanent neurologic deﬁcits are common in patients that survive, but the mechanism leading to this pathology is poorly understood, impeding clinical advancements in treatment to reduce CNS morbidity. Using magnetic resonance imaging and type I IFN receptor–deﬁcient mouse chimeras, we demonstrate HSV-1 gains access to the murine brain stem and subsequently brain ependymal cells, leading to enlargement of the cerebral lateral ventricle and infection of the brain parenchyma. A similar enlargement in the lateral ventricles is found in a subpopulation of herpes simplex encephalitic patients. Associated with encephalitis is an increase in CXCL1 and CXCL10 levels in the cerebral spinal ﬂuid, TNF- a expression in the ependymal region, and the inﬂux of neutrophils of encephalitic mouse brains. Reduction in lateral ventricle enlargement using anti-secretory factor peptide 16 reduces mortality signiﬁcantly in HSV-1–infected mice without any effect on expression of inﬂammatory mediators, inﬁltration of leukocytes, or changes in viral titer. Microglial cells but not inﬁltrating leukocytes or other resident glial cells or neurons are the principal source of resistance in the CNS during the ﬁrst 5 d postinfection through a Toll/IL-1R domain-containing adapter inducing IFN- b –dependent, type I IFN pathway. Our results implicate lateral ventricle enlargement as a major cause of mortality in mice and speculate such an event transpires in a subpopulation
STUDY OF ST-ELEVATION MYOCARDIAL INFARCTION (STEMI) AND THE FREQUENCY OF ITS RISK FACTORS

: Objective: The main purpose of this study was to find out the repetition rate of perilous reasons concerned with ST-Elevation Myocardial Infarction (STEMI) patients. Study Design: Cross-sectional analysis study. Place and Duration: The study was conducted in the Cardiology department of Mayo Hospital, Lahore from January, 2018 to August, 2018 Materials and Methods: A total number of 105 patients were selected for our study. Used non-probability convenient sampling technique for selection. Data about the presence or absence of risk factors was collected through interviewing all patients. Included the lifestyle, stress, obesity,hypertension and diabetes mellitus as the associated risk factors. The gathered data was analyzed by using SPSS 23. Results: Gender distribution of masculine and feminine was as 60.2% and 39.8% accordingly. Percentage of non-STEMI and STEMI patients out of all selected patients (105) was as 20.9% and 79.1% respectively. Mean age of the patients was 60.5 ± 12.0 years. STEMI and Non-STEMI mean ± SD of age was 61.55±11.513 years and 56.50±13.172 years. Found statistically insignificant difference amongmean age of STEMI and Non-STEMI with P value as equal to 0.079. Amongst the STEMI patients overweight, non-regular fruit eaters, patients with history of stress, sedentary lifestyle, patients of diabetes, hypertensive, smokers and with positive family history of STEMI were as 20.50%, 39.80%, 24.10%, 69.90%, 28.90%, 63.90%, 27.70% and 36.10% respectively.Non-STEMI patients were having low mean age than STEMI patients. Statistically significant factors were not found. Conclusions: Sedentary lifestyle followed by family history of STEMI and hypertension was the most common risk factor of STEMI. Obesity was the least common risk factor. Any other factor was found to have no considerable association with ST-Elevation Myocardial Infarction (STEMI).
Halo concentrations in the standard (cid:2) cold dark matter cosmology

We study the concentration of dark matter haloes and its evolution in N -body simulations of the standard (cid:3) cold dark matter ( (cid:3) CDM) cosmology. The results presented in this paper are based on four large N -body simulations with ∼ 10 billion particles each: the Millennium-I and -II, Bolshoi and MultiDark simulations. The MultiDark (or BigBolshoi) simulation is introduced in this paper. This suite of simulations with high mass resolution over a large volume allows us to compute with unprecedented accuracy the concentration over a large range of scales (about six orders of magnitude in mass), which constitutes the state of the art of our current knowledge on this basic property of dark matter haloes in the (cid:3) CDM cosmology. We ﬁnd that there is consistency among the different simulation data sets, despite the different codes, numerical algorithms and halo/subhalo ﬁnders used in our analysis. We conﬁrm a novel feature for halo concentrations at high redshifts: a ﬂattening and upturn with increasing mass. The concentration c ( M , z ) as a function of mass and the redshift and for different cosmological parameters shows a remarkably complex pattern. However, when expressed in terms of the linear rms ﬂuctuation of the density ﬁeld σ ( M , z ), the halo concentration c ( σ ) shows a nearly universal simple U-shaped behaviour with a minimum at a well-deﬁned scale at σ ∼ 0.71. Yet, some small dependences with redshift and cosmology still remain. At the high-mass end ( σ < 1), the median halo kinematic proﬁles show large signatures of infall and highly radial orbits. This c – σ ( M , z ) relation can be accurately parametrized and provides an analytical model for the dependence of concentration on halo mass. When applied to galaxy clusters, our estimates of concentrations are substantially larger – by a factor up to 1.5 – than previous results from smaller simulations, and are in much better agreement with results of observations.
Vitamin D Levels and Seasonal Changes in Elderly Cretans, Men and Women

Background: Low serum 25-hydroxyvitamin D [s25(OH)D] levels have been reported in a high proportion of institutionalized or home bound subjects and also in ambulatory elderly people with limited exposure to sunlight due to geographical location. Aim of this study is to investigate the s25(OH)D status as well as its seasonal variation in ambulatory elderly people permanent inhabitants of Crete, the southernmost island of Europe. Subjects and Methods: 101 ambulatory subjects, selected after applying strict exclusion criteria, from the Centres of Open Care for the Elderly, of Heraklion-Crete, 70 women and 31 men, (70,00±5,00 years and 73,00±5,49 respectively) Serum 25(OH)D, serum parathormone (sPTH), Ca, P, Cre, BMI and grade of mobility were assessed. In a subgroup of 25 subjects, s25(OH)D and sPTH were evaluated twice (winter and summer). Results: Mean s25(OH)D was 51,46±27,32 nmol/L in women and 71,7±28,65 nmol/L in men. Levels ≤ 30nmol/L were found to 10% of men and 30% of women whereas levels ≤ 50nmol/L were found to 29% of men and 53,6% of women. Mean sPTH was 59,77±28,92 pg/ml in women and 63,91±24,82 in men Subjects with mobility A had higher levels of s25(OH)D than subjects with mobility B (t (99) =3,612 p=0,000) and summer levels of s25(OH)D were higher than the winter ones (p<0,001) whereas summer levels of sPTH were lower (p=0,007). Conclusion: Despite of the geographic location of Crete, and the Μediterranean diet followed, there is a high prevalence of vitamin D deficiency among ambulatory community dwelling elderly, being much higher in women, which can be attributed to the inadequate exposure to sunlight and to the lack of foods fortified with vitamin D and/or the supplementation of Vitamin D.
"All models are wrong, but some are useful."

In the last few decades, major advances have been made in the way we collect and generate data in all aspects of life. At the same time, the technical approaches for analyzing and interpreting datasets have improved. The intersection of these trends is referred to as Big Data and this plays an important role in precision medicine and other fields of computer science. Feature selection algorithms have contributed to considerable progress in coping with the growing amount of machine readable information. They can identify a minimal set of features that are relevant for developing highly accurate prediction models. Thus, feature selection simplifies the interpretability as well as computability of big datasets. Many different feature selection methods already exist. Previous studies have shown that some of these are biased, depending on the feature type and dataset quality. In this thesis, an ensemble consisting of eight different feature selection methods (EFS) is introduced. An ensemble of learning algorithms has the advantage of being able to address the biases of the individual approaches. Additionally, EFS provides a cumulative quantitative feature ranking. EFS was applied on several biomedical datasets. Different feature subset selections resulting from the EFS ranking were evaluated on three popular prediction models, namely logistic regression, random forest and support vector machine. In most cases, a significant improvement of the prediction performance could be achieved when compared to the same models constructed with all features. The EFS approach and the evaluations were implemented as an R package EFS as well as a web-based application. A quantitative feature ranking and a cumulative barplot of the feature’s importance values are provided as the output.
The effect of leadership, motivation, and work discipline on the employees’ performance of finance section in the regional working unit in Tulungagung regency

The role of local government has been increasing significantly since the enactment of regional autonomy by the central government. In this case, the majority of central government authorities are delegated to each local government. Consequently, the success of development and economy of the region depends largely on the local government concerned. The performance of local governance will run well, if there is adequate government apparatus that support the local government activities. The good performance of the government apparatus will have an impact on the achievement of goals and responsibilities of the local government, the central government and the public. Therefore, the purpose of this study is to find out whether variables of leadership, motivation and work discipline can affect the performance of employees of finance section in the regional working units of Tulungagung Regency. The samples in this study are the employees of finance section in the Regional Working Units of Tulungagung Regency. Based on the multiple linear regression analysis test, it can be concluded that the variables of leadership and work discipline have significant effect on the performance of employees, while the variable of motivation does not have significant effect on the performance of employees of finance section in the Regional Working Units of Tulungagung Regency.