Miracle-dz/UniFAR-FTUs huggingface dataset:
Catalogue of representative meteor spectra

Aims. We present a library of low-resolution meteor spectra that includes sporadic meteors, members of minor meteor showers, and major meteor showers. These meteors are in the magnitude range from +2 to −3, corresponding to meteoroid sizes from 1 mm to 10 mm. Methods. Parallel double-station video observations allowed us to compute heliocentric orbits for all meteors. Most observations were performed during the periods of activity of major meteor showers in the years between 2006 and 2012. Spectra are classified according to relative intensities of the low-temperature emission lines of Mg, Na, and Fe. Results. Shower meteors were found to be of normal composition, except for Southern δ Aquariids and some members of the Geminid shower, neither of which have Na in the meteor spectra. Variations in Na content are typical for the Geminid shower. Three populations of Na-free mereoroids were identified. The first population are iron meteorites, which have an asteroidal-chondritic origin, but one meteoroid with low perihelion (0.11 AU) was found among the iron meteorites. The second population were Sun-approaching meteoroids in which sodium is depleted by thermal desorption. The third population were Na-free meteoroids of cometary origin. Long exposure to cosmic rays on the surface of comets in the Oort cloud and disintegration of this crust might be the origin of this population of meteoroids.
Fluid intake is a strong predictor of outdoor team sport pre-season training performance

ABSTRACT Our aim was to characterize fluid intake during outdoor team sport training and use generalized additive models to quantify interactions with the environment and performance. Fluid intake, body mass (BM) and internal/external training load data were recorded for male rugby union (n = 19) and soccer (n = 19) athletes before/after field training sessions throughout an 11-week preseason (357 observations). Running performance (GPS) and environmental conditions were recorded each session and generalized additive models were applied in the analysis of data. Mean body mass loss throughout all training sessions was −1.11 ± 0.63 kg (~1.3%) compared with a mean fluid intake at each session of 958 ± 476 mL during the experimental period. For sessions >110 min, when fluid intake reached ~10–19 mL·kg−1 BM the total distance increased (7.47 to 8.06 km, 7.6%; P = 0.049). Fluid intake above ~10 mL·kg−1 BM was associated with a 4.1% increase in high-speed running distance (P < 0.0001). Most outdoor team sport athletes fail to match fluid loss during training, and fluid intake is a strong predictor of running performance. Improved hydration practices during training should be beneficial and we provide a practical ingestion range to promote improved exercise capacity in outdoor team sport training sessions.
Expression of α‐Synuclein in the mouse retina is confined to inhibitory presynaptic elements

α‐Synuclein (α‐Syn) is enriched in presynaptic terminals of the central nervous system including the retina and plays a role in the synaptic vesicle cycle and synaptic transmission. Abnormal aggregation of α‐Syn is considered to be the main component of the Lewy bodies that are the pathological hallmarks of Parkinson's disease. Although expression pattern of α‐Syn has been described in the retinas, its precise cellular and subcellular locations are poorly understood. We investigated the precise expression of α‐Syn using light microscopy (LM) and electron microscopy (EM) with antibodies against α‐Syn in the mouse retina. We found that the majority of α‐Syn immunoreactivity (IR) is located in GABAergic, glycinergic, and dopaminergic amacrine cells, and their processes often make a direct synapse to other labeled or unlabeled amacrine profiles, bipolar cell terminals, or ganglion cell dendrites. Further, our LM and immuno‐EM results confirm the absence of α‐Syn in excitatory photoreceptors, bipolar cell bodies, and their ribbon synapses, providing evidence, for the first time, that ribbon synapses do not express α‐Syn. Additionally, α‐Syn IR is located in the ganglion cells, some of which are intrinsically photosensitive retinal ganglion cells. These results reveal a previously unappreciated inhibitory synapse‐specific expression pattern of α‐Syn in the retina, suggesting that α‐Syn may play a distinct role in the modulation and integration of inhibitory synaptic transmission in the retina.
Model‐based simulation to support the approval of isatuximab alone or with dexamethasone for the treatment of relapsed/refractory multiple myeloma in Japanese patients

This study aimed to support dosing regimen selection for isatuximab as a single agent or in combination with dexamethasone for Japanese patients with relapsed/refractory multiple myeloma (RRMM). A joint model characterizing the dynamics of serum M‐protein kinetics and its association with progression‐free survival (PFS) was developed using data from 201 evaluable Japanese and non‐Japanese patients with RRMM enrolled in two monotherapy phase I/II trials, where Japanese patients (n = 31) received isatuximab at 10 or 20 mg/kg once weekly (qw) for 4 weeks then every 2 weeks (q2w) in subsequent cycles (10 or 20 mg/kg qw–q2w). Among non‐Japanese patients, 38 received isatuximab 20 mg/kg qw–q2w in combination with dexamethasone. Trial simulations were then performed to evaluate the effect of the isatuximab dosing regimens on both serum M‐protein and PFS with and without dexamethasone. The model identified instantaneous changes in serum M‐protein as the best on‐treatment predictor for PFS. Trial simulations demonstrated that 20 mg/kg qw–q2w induced a greater decrease (30% vs. 22%) of serum M‐protein at week 8 and prolonged median PFS by 2.4 weeks compared with 10 mg/kg qw–q2w. Although Japanese patients did not receive isatuximab plus dexamethasone in the phase I/II trial, simulations predicted that isatuximab 20 mg/kg qw–q2w plus dexamethasone would induce a greater decrease (67% vs. 43%) of serum M‐protein and a prolonged median PFS by 7.2 weeks compared with isatuximab alone. Trial simulations support the approved isatuximab 20 mg/kg qw–q2w regimen when administered as a single agent and in combination with dexamethasone in Japanese patients.
Investigation of the effect of magnetic field on melting of solid gallium in a bottom-heated rectangular cavity using the lattice Boltzmann method

ABSTRACT A numerical study is presented for two-dimensional convection melting of solid gallium in a rectangular cavity. The bottom wall of the cavity is uniformly heated and a uniform magnetic field is applied separately in both horizontal and vertical directions. The lattice Boltzmann (LB) method considering the magnetic field force is employed to solve the governing equations. The effects of magnetic field on flow and heat transfer during melting are presented and discussed at Rayleigh number Ra = 1 × 105 and Hartmann number Ha = 0, 15, and 30. The results show that the magnetic field with an inclination angle has a significant impact on the flow and heat transfer in the melting process. For a small Hartmann number, similar melting characteristics are observed for both horizontally applied and vertically applied magnetic fields. For a high value of Hartmann number, it is found that in the earlier stage of melting process, the flow retardation effect caused by the horizontally applied magnetic field is less obvious than that caused by the vertically applied magnetic field. However, the opposite is true in the later stage.
Exploratory Examination of Speech Disfluencies in Spoken Narrative Samples of School-Age Bidialectal Children.

PURPOSE This study examined the relationship between school-age children's speech disfluencies and the use of and variation of Mainstream American English (MAE) and African American English (AAE). Given that bilingual children may present with notably more speech disfluencies than monolingual children, it was hypothesized that bidialectal speaking children (i.e., those that use both MAE and AAE) may exhibit higher speech disfluencies, as compared to children who speak mainly MAE and those who mainly speak AAE. It was also hypothesized that bidialectal speaking children would exhibit a greater variety of speech disfluency types when compared to the other two dialect groups (i.e., MAE and AAE). METHOD School-age children (n = 61) with typical development and fluency were classified into three dialect groups: MAE speakers (n = 21), bidialectal MAE-AAE speakers (n = 11), and AAE speakers (n = 29). Tell-retell narrative samples were elicited from each participant using a wordless picture book. Speech disfluencies exhibited during these narrative samples were examined for frequency of stuttering-like and nonstuttering-like speech disfluencies and type of speech disfluency. RESULTS Findings indicated that bidialectal speaking children do not present with a higher frequency of speech disfluencies when compared to children who speak MAE and children who speak AAE. Additionally, there were no differences in the types of speech disfluencies exhibited by the different dialect groups. CONCLUSIONS Unexpected findings of this study nullify both hypotheses and suggest that bidialectalism, in comparison to bilingualism, has less of an impact on speech fluency. Findings provide evidence that bidialectal speaking children are not at an increased risk for a misdiagnosis of stuttering. Clinically, these preliminary findings provide some scientific validity and specification to the appropriateness of using already established diagnostic criteria commonly used for stuttering with dialect speakers.
Stress, Sleep, and Resilience Among Rural BSN Students in a New Nursing Program

Background: Nursing students experience stress that may impact their sleep and resilience, especially those attending rural campuses that may have potentially limited access to resources. Purpose: The purpose of this study was to examine relationships among perceived stress, sleep quality, resilience, and demographics and predictors of resilience among senior BSN students. Methods: In this cross-sectional study, perceived stress, sleep quality, resilience, and demographic data were collected from a senior student cohort attending a new baccalaureate nursing program on a rural Appalachian campus (N = 16). Data were analyzed using descriptive, bivariate, and multiple regression analyses. Results: Perceived stress significantly associated with sleep quality, resilience, and gender. Perceived stress, sleep quality, and gender significantly explained 61% of the variance in resilience, with perceived stress as the strongest predictor. Conclusions: Early collaborative assessment and intervention focused on mitigating stress may promote improved sleep and resilience. Availability of resources for students attending small rural campuses is essential.
Sex‐specific risk factors for early‐onset ischaemic stroke

The aim of this study is to investigate sex‐specific risk factors for early‐onset ischaemic stroke (men <55 and women <65 years old) in the Chinese population. We included 1,270 participants with their first early‐onset ischaemic stroke after the baseline survey and 5,080 age‐matched (±2 years) and sex‐matched participants, which was an ongoing prospective cohort study conducted in the Kailuan community in Tanshan City, China. A conditional multivariate logistic regression model (backward) was used to analyse the sex‐specific risk factors for early‐onset ischaemic stroke. The effects of the risk factors were assessed by calculating standardized regression coefficients. The modifying effect of sex was explored using multiplicative interaction terms of sex with each of the risk factors, and sex‐specific risk factors were identified by stratifying the main regression analysis by sex. There were 1,270 early‐onset ischaemic strokes, 71% occurred in men and 29% in women. The control group included 5,080 participants. The top three risk factors for early‐onset ischaemic stroke were hypertension (beta = .21), diabetes mellitus (beta = .21) and adverse pregnancy outcomes (beta = .14) in women and hypertension (beta = .26), increased hs‐CRP (beta = .14) and diabetes mellitus (beta = .09) in men. There were significant interactions of sex with diabetes mellitus and systolic blood pressure (SBP). The effect of diabetes on early‐onset ischaemic stroke was stronger in women (odds ratio [OR] = 2.69) than in men (OR = 1.61), but the effect weakened with each standard deviation increase in SBP (OR: 1.30 vs. 1.68). Our study found that the effects of risk factors for early‐onset ischaemic stroke, especially diabetes mellitus and SBP, varied by sex.
Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis

The association between nonalcoholic fatty liver disease (NAFLD) with cardiovascular and cerebrovascular outcomes, as well as their clinical impact, has yet to be established in the literature. This meta-analysis aims to evaluate the association between the NAFLD patients and the risk of atrial fibrillation (AF), heart failure (HF), stroke, cardiovascular mortality (CVM), and revascularization incidence. We performed a systematic literature search using PubMed, Embase, Scopus, and Cochrane libraries for relevant articles from inception until August 2022. A total of 12 cohort studies with 18,055,072 patients (2,938,753 NAFLD vs 15,116,319 non-NAFLD) were included in our analysis. The mean age of the NAFLD patients group and the non-NAFLD group was comparable (55.68 vs 55.87). The most common comorbidities among the NAFLD patients group included hypertension (38% vs 24%) and diabetes mellitus (14% vs 8%). The mean follow-up duration was 6.26 years. The likelihood of AF (risk ratio (RR), 1.42 (95% CI 1.19, 1.68), p < 0.001), HF (RR, 1.43(95% CI 1.03, 2.00), p < 0.001), stroke (RR, 1.26(95% CI 1.16, 1.36), p < 0.001), revascularization (RR, 4.06(95% CI 1.44, 11.46), p = 0.01), and CVM (RR, 3.10(95% CI 1.43, 6.73), p < 0.001) was significantly higher in the NAFLD patients group compared to that of the non-NAFLD group. However, all-cause mortality was comparable between both the groups of patients (RR, 1.30 (95% CI 0.63, 2.67), p = 0.48). In conclusion, the patients with NAFLD are at increased risk of AF, HF, and CVM.
Light therapy in insomnia disorder: A systematic review and meta‐analysis

In the management of insomnia, physicians and patients are seeking alternative therapeutics to sleeping pills, in addition to sleep hygiene and cognitive behavioural therapy. Bright light therapy (LT) has proven its efficacy in circadian and mood disorders. We conducted a systematic literature review and meta‐analysis according to Cochrane and PRISMA guidelines and using the databases Medline, Cochrane, and Web of Science, with a special focus on light therapy and insomnia. Twenty‐two studies with a total of 685 participants were included, five of which with a high level of proof. Meta‐analysis was performed with 13 of them: light therapy for insomnia compared with control conditions significantly improved wake after sleep onset (WASO: SMD = −0.61 [−1.11, −0.11]; p = 0.017; weighted difference of 11.2 min ±11.5 based on actigraphy, and SMD = −1.09 [−1.43, −0.74] (p < 0.001) weighted difference of −36.4 min ±15.05) based on sleep diary, but no other sleep measures such as sleep latency, total sleep time (TST), or sleep efficiency. Qualitative analysis of the review showed some improvement mainly in subjective measures. Morning light exposure advanced sleep–wake rhythms and evening exposure led to a delay. No worsening was observed in objective nor subjective measures, except for TST in one study with evening exposure. A light dose–response may exist but the studies’ heterogeneity and publication bias limit the interpretation. To conclude, light therapy shows some effectiveness for sleep maintenance in insomnia disorders, but further research is needed to refine the light parameters to be chosen according to the type of insomnia, in the hope of developing personalised therapeutics.
Utility of preoperative urine cultures and cystoscopies before ureteral reimplantation in pediatrics

Background: Ureteral reimplantation remains the primary surgical method used for patients with vesicoureteral reflux (VUR). Cystoscopy is commonly performed first to visualize anatomy and rule out possible abnormalities. Urine cultures may also be obtained. The objective of this study is to evaluate the prudency of preoperative urine cultures and cystoscopies in pediatric patients undergoing ureteral reimplantation. Methods: Pediatric urologists were surveyed regarding collecting urine cultures in asymptomatic patients and cystoscopies before reimplantation. A retrospective review was also conducted of patients who underwent ureteral reimplantation for VUR between March 2018 and April 2021 at Cook Children’s Medical Center. Results: When physicians were asked the frequency they obtain urine cultures before reimplantation on asymptomatic patients, 36% said “never” and 38% said “always. ” Regarding cystoscopy, 53% said “never” and 32% said “always. ” Inclusion criteria were met by 101 patients. Cystoscopies were performed in 46 patients and never altered the reimplantation. There were 20 preoperative, 90 intraoperative, and 61 postoperative urine cultures. Complications were associated with positive cultures of urine collected intraoperatively and postoperatively only. Conclusion: Cystoscopies and asymptomatic urine cultures obtained before ureteral reimplantation provide no additional benefit while increasing cost for patients’ families. Further research is needed to thoroughly identify the prudency of such practices in ureteral reimplantation for VUR.
View cells in the hippocampus and prefrontal cortex of macaques during virtual navigation

Cells selectively activated by a particular view of an environment have been found in the primate hippocampus (HPC). Whether view cells are present in other brain areas, and how view selectivity interacts with other variables such as object features and place remain unclear. Here, we explore these issues by recording the responses of neurons in the HPC and the lateral prefrontal cortex (LPFC) of rhesus macaques performing a task in which they learn new context‐object associations while navigating a virtual environment using a joystick. We measured neuronal responses at different locations in a virtual maze where animals freely directed gaze to different regions of the visual scenes. We show that specific views containing task relevant objects selectively activated a proportion of HPC units, and an even higher proportion of LPFC units. Place selectivity was scarce and generally dependent on view. Many view cells were not affected by changing the object color or the context cue, two task relevant features. However, a small proportion of view cells showed selectivity for these two features. Our results show that during navigation in a virtual environment with complex and dynamic visual stimuli, view cells are found in both the HPC and the LPFC. View cells may have developed as a multiarea specialization in diurnal primates to encode the complexities and layouts of the environment through gaze exploration which ultimately enables building cognitive maps of space that guide navigation.
Limitations of using 16S rRNA microbiome sequencing to predict oral squamous cell carcinoma

A new era of next‐generation sequencing has changed our perception of the oral microbiome in health and disease, and with this there is a growing understanding that the oral microbiome is a contributing factor to oral squamous cell carcinoma (OSCC), a malignancy of the oral cavity. This study aimed to analyse the trends and relevant literature based on the 16S rRNA oral microbiome in head and neck cancer using next‐generation sequencing technologies, and to conduct a meta‐analysis of the studies with OSCC cases and healthy controls. A literature search using the databases Web of Science and PubMed was conducted in a scoping‐like review to collect information based on the study design, and plots were generated using RStudio. We selected case–control studies using 16S rRNA oral microbiome sequencing analysis in OSCC cases versus healthy controls for re‐analysis. Statistical analyses were conducted using R. Out of 916 original articles, we filtered and selected 58 studies for review, and 11 studies for meta‐analysis. Differences between sampling type, DNA extraction methods, next‐generation sequencing technology and region of the 16S rRNA were identified. No significant differences in the α‐ and β‐diversity between health and oral squamous cell carcinoma were observed (p < 0.05). Random Forest classification marginally improved predictability of four studies (training set) when split 80/20. We found an increase in Selenomonas, Leptotrichia and Prevotella species to be indicative of disease. A number of technological advances have been accomplished to study oral microbial dysbiosis in oral squamous cell carcinoma. There is a clear need for standardization of study design and methodology to ensure 16S rRNA outputs are comparable across the discipline in the hope of identifying ‘biomarker’ organisms for designing screening or diagnostic tools.
Evaluating ropeginterferon alfa-2b for the treatment of adults with polycythemia vera

ABSTRACT Introduction Interferons (IFNs) have been used for decades to treat polycythemia vera (PV). Single-arm clinical trials assessing IFN in PV patients demonstrated high hematological and molecular response rates, indicating potential disease-modifying activity of IFN. However, discontinuation rates of IFNs have been rather high due to frequent treatment-related side-effects. Areas covered Ropeginterferon alfa-2b (ROPEG) is a monopegylated IFN consisting of a single isoform, which differentiates it from previous IFNs with respect to tolerability and dosing frequency. ROPEG has improved pharmacokinetic and pharmacodynamic properties, which allow extended dosing every 2 weeks and monthly administration during maintenance phase. This review covers ROPEG’s pharmacokinetic and pharmacodynamic properties, presents results of randomized clinical trials (RCT) that evaluated ROPEG in the treatment of PV patients, and discusses contemporary findings regarding the potential disease-modifying activity of ROPEG. Expert opinion RCT have demonstrated high rates of hematological and molecular responses in PV patients treated with ROPEG, irrespective of thrombotic risk. Drug discontinuation rates were generally low. However, even though RCT captured the most important surrogate endpoints of thrombotic risk and disease progression in PV, they were not statistically powered to fully determine whether therapeutic intervention with ROPEG indeed has a direct positive effect on these important clinical outcomes.