Miracle-dz/UniFAR-FTUs huggingface dataset:
Feeding/Eating Problems in Children Who Refrained From Treatment in the Past: Who Did (Not) Recover?

Background Young children with disordered feeding may be at increased risk for problematic eating in the future. This retrospective study attempts to identify predictors of later feeding problems. Objectives Children (N = 236) with disordered feeding, who refrained from behavioral treatment after consultation at a tertiary treatment center for feeding and eating problems were followed-up after, on average, 6 years and 3 months (timepoint 2). Method Logistic regressions were carried out with characteristics taken at intake (timepoint 1)—sex, pre/dysmaturity, gastro-intestinal disease, history of age-adequate feeding, syndrome/developmental impairment, autism spectrum disorder, comorbidity, age, and several variables of a restrictive- and selective food intake—and duration between timepoint 1 and 2, as predictor variables, and age-appropriate food intake at t2 as the dependent variable. Results Despite improvement over time, 63% did not reach an age-adequate food intake at t2. Predictors of age-inadequate food intake were: (a) older age; (b) sex (male), (c) longer duration between timepoint 1 and timepoint 2; (d) autism spectrum disorder; (e) selective texture choices and (f) lack of varied nutritional intake. Conclusion This study shows that most untreated young children's feeding problems do not improve over years. Besides the advice to seek help at an early age, it seems especially recommended to treat (male) children with autism spectrum disorder and selective feeding patterns.
DEM analysis of ultimate lateral resistance to rigid short piles in sand

A DEM numerical model is constructed for analysis of ultimate lateral resistance to piles in sand. The pile was modeled as a rigid body with two kinds of pile movements: rotational and translational movement, simulating free head and fixed head condition, respectively. In the numerical experiments, the lateral resistance, lateral pressure distribution along the pile and the displacement of pile at different depths can be measured and used to construct p-y curve. In addition, the soil-pile interaction can be examined in detail to reveal the extent of influence due to the movement of the pile. In general, the results of the numerical simulation were compared favorably with other semi-empirical solutions.
The Potential of Chitosan in Nanomedicine: An Overview of the Cytotoxicity of Chitosan Based Nanoparticles

The unique properties and applications of nanotechnology in targeting drug delivery, cosmetics, fabrics, water treatment and food packaging have received increased focus the last two decades. The application of nanoparticles in medicine is rapidly evolving, requiring careful investigation of toxicity before clinical use. Chitosan, a derivative of the natural polysaccharide chitin, has become increasingly relevant in modern medicine because of its unique properties as a nanoparticle. Chitosan is already widely used as a food additive and in food packaging, bandages and wound dressings. Thus, with an increasing application worldwide, cytotoxicity assessment of nanoparticles prepared from chitosan is of great interest. The purpose of this review is to provide an updated status of cytotoxicity studies scrutinizing the safety of chitosan nanoparticles used in biomedical research. A search in Ovid Medline from 23 March 1998 to 4 January 2022, with the combination of the search words Chitosan or chitosan, nanoparticle or nano particle or nanosphere or nanocapsule or nano capsule, toxicology or toxic or cytotoxic and mucosa or mucous membrane resulted in a total of 88 articles. After reviewing all the articles, those involving non-organic nanoparticles and cytotoxicity assays conducted exclusively on nanoparticles with anti-tumor effect (i.e., having cytotoxic effect) were excluded, resulting in 70 articles. Overall, the chitosan nanoparticles included in this review seem to express low cytotoxicity regardless of particle composition or cytotoxicity assay and cell line used for testing. Nonetheless, all new chitosan derivatives and compositions are recommended to undergo careful characterization and cytotoxicity assessment before being implemented on the market.
Selenium Biofortification of Soybean Sprouts: Effects of Selenium Enrichment on Proteins, Protein Structure, and Functional Properties

Selenium (Se) biofortification during germination is an efficient method for producing Se-enriched soybean sprouts; however, few studies have investigated Se distribution in different germinated soybean proteins and its effects on protein fractions. Herein, we examined Se distribution and speciation in the dominant proteins 7S and 11S of raw soybean (RS), germinated soybean (GS), and germinated soybean with Se biofortification (GS-Se). The effects of germination and Se treatment on protein structure, functional properties, and antioxidant capacity were also determined. The Se concentration in GS-Se was 79.8-fold higher than that in GS. Selenomethionine and methylselenocysteine were the dominant Se species in GS-Se, accounting for 41.5–80.5 and 19.5–21.2% of the total Se with different concentrations of Se treatment, respectively. Se treatment had no significant effects on amino acids but decreased methionine in 11S. In addition, the α-helix contents decreased as the Se concentration increased; the other structures showed no significant changes. The Se treatment also had no significant effects on the water and oil-holding capacities in protein but increased the foaming capacity and emulsion activity index (EAI) of 7S, but only the EAI of 11S. The Se treatment also significantly increased the antioxidant capacity in 7S but not in 11S. This study indicates that the dominant proteins 7S and 11S have different Se enrichment abilities, and the protein structures, functional properties, and antioxidant capacity of GS can be altered by Se biofortification.
The Open-Ocean Gulf of Mexico After Deepwater Horizon: Synthesis of a Decade of Research

The scale of the Deepwater Horizon disaster was and is unprecedented: geographic extent, pollutant amount, countermeasure scope, and of most relevance to this Research Topic issue, range of ecotypes affected. These ecotypes include coastal/nearshore, continental shelf, deep benthic, and open-ocean domains, the last of which is the subject of this synthesis. The open-ocean ecotype comprises ~90% of the volume of the Gulf of Mexico. The exact percentage of this ecotype contaminated with toxins is unknown due to its three-dimensional nature and dynamics, but estimates suggest that the footprint encompassed most of its eastern half. Further, interactions between the water column and the deep benthos may be persistent, making this synthesis one of time (a decade) rather than event conclusion. Here we examine key elements of the open-ocean ecosystem, with emphasis on vulnerability and resilience. Of paramount importance relative to the Gulf nearshore and shelf ecotypes, pre-disaster baseline data were lacking for most of the fauna. In such cases, inferences were drawn from post-disaster assessments. Both phytoplankton and mesozooplankton vulnerabilities were quite high, but resilience appeared equally so. The phytoplankton situation was a bit more complex in that toxin-imposed reductions may have been offset by nutrient injection via high freshwater discharge in 2010. Intermediate trophic levels exhibited population-level depressions, ostensibly due to high vulnerability and low resilience. Apex predator impacts were variable. Certain large epipelagic fishes may have avoided the highest concentrations of hydrocarbons/dispersant, and thus larval abundances returned to pre-disaster levels of variability and abundance within a few years after a steep initial decline. Oceanic cetaceans, particularly shallow-diving stenellid dolphins, did not appear to avoid oiled waters and exhibited strong declines in the northern Gulf. Given that population declines of many open-ocean taxa appear to be ongoing a decade later, we conclude that this largest of Gulf ecosystem components, like its deep-benthic counterpart, is as fragile as it is voluminous. This is particularly concerning given the rapid, and likely irreversible, shift to deeper waters by the US and Mexican oil industries in concert with the higher likelihood of accidents with increasing platform depth.
The Effect of Spontaneous LH Surges on Pregnancy Outcomes in Patients Undergoing Letrozole-HMG IUI: A Retrospective Analysis of 6,285 Cycles

Background To date, no consensus has been reached on whether to wait for spontaneous luteinizing hormone (LH) surge to occur or to trigger ovulation regardless of the presence of an LH surge for achieving higher success rate in intrauterine insemination (IUI) cycles. Therefore, we hope to investigate the effect of the presence of a spontaneous LH surge on pregnancy outcomes in letrozole–human menopausal gonadotropin (LE-HMG) IUI cycles. Methods In this retrospective cohort study, a total of 6,285 LE-HMG IUI cycles were included between January 2010 and May 2021. Cycles were categorized into three groups: the trigger + LH surge group, the trigger only group, and the LH surge only group. The primary outcome measure was the clinical pregnancy rate. A logistic regression analysis was performed to explore other risk factors affecting the clinical pregnancy rate. Results No significant differences were observed in biochemical pregnancy rate (P =0.640), clinical pregnancy rate (P =0.702), ongoing pregnancy rate (P =0.842), and live birth rate (P =0.951) among the three groups. The binary logistic regression analysis also confirmed that the existence of an LH surge was not associated with clinical pregnancy. There was a difference in ectopic pregnancy rates (P =0.045), but logistic regression showed that the presence of a spontaneous LH surge has no association with ectopic pregnancy. Nonetheless, patients with lead follicles within 18.1-20.0 mm/20.1-22.0 mm and a long duration of LE treatment were less likely to get ectopic pregnant compared with patients with 14.1-16.0 mm lead follicles and shorter LE treatment (OR: 0.142, 95% CI: 0.023–0.891, P =0.037; OR: 0.142, 95% CI: 0.022–0.903, P =0.039; OR: 0.445, 95% CI: 0.235–0.840, P = 0.013). Conclusions The presence of a spontaneous LH surge in triggered LE-HMG IUI cycles does not appear to improve pregnancy rates. Thus, we suggest that waiting for an LH surge to occur is not necessary in triggered LE-HMG IUI cycles.
Behavioral Training Related Neurotransmitter Receptor Expression Dynamics in the Nidopallium Caudolaterale and the Hippocampal Formation of Pigeons

Learning and memory are linked to dynamic changes at the level of synapses in brain areas that are involved in cognitive tasks. For example, changes in neurotransmitter receptors are prerequisite for tuning signals along local circuits and long-range networks. However, it is still unclear how a series of learning events promotes plasticity within the system of neurotransmitter receptors and their subunits to shape information processing at the neuronal level. Therefore, we investigated the expression of different glutamatergic NMDA (GRIN) and AMPA (GRIA) receptor subunits, the GABAergic GABARG2 subunit, dopaminergic DRD1, serotonergic 5HTR1A and noradrenergic ADRA1A receptors in the pigeon’s brain. We studied the nidopallium caudolaterale, the avian analogue of the prefrontal cortex, and the hippocampal formation, after training the birds in a rewarded stimulus-response association (SR) task and in a simultaneous-matching-to-sample (SMTS) task. The results show that receptor expression changed differentially after behavioral training compared to an untrained control group. In the nidopallium caudolaterale, GRIN2B, GRIA3, GRIA4, DRD1D, and ADRA1A receptor expression was altered after SR training and remained constantly decreased after the SMTS training protocol, while GRIA2 and DRD1A decreased only under the SR condition. In the hippocampal formation, GRIN2B decreased and GABARG2 receptor expression increased after SR training. After SMTS sessions, GRIN2B remained decreased, GABARG2 remained increased if compared to the control group. None of the investigated receptors differed directly between both conditions, although differentially altered. The changes in both regions mostly occur in favor of the stimulus response task. Thus, the present data provide evidence that neurotransmitter receptor expression dynamics play a role in the avian prefrontal cortex and the hippocampal formation for behavioral training and is uniquely, regionally and functionally associated to cognitive processes including learning and memory.
Osteoarticular Infections in Pediatric Hospitals in Europe: A Prospective Cohort Study From the EUCLIDS Consortium

Background Pediatric osteoarticular infections (POAIs) are serious diseases requiring early diagnosis and treatment. Methods In this prospective multicenter cohort study, children with POAIs were selected from the European Union Childhood Life-threatening Infectious Diseases Study (EUCLIDS) database to analyze their demographic, clinical, and microbiological data. Results A cohort of 380 patients with POAIs, 203 with osteomyelitis (OM), 158 with septic arthritis (SA), and 19 with both OM and SA, was analyzed. Thirty-five patients were admitted to the Pediatric Intensive Care Unit; out of these, six suffered from shock, one needed an amputation of the right foot and of four left toes, and two had skin transplantation. According to the Pediatric Overall Performance Score, 36 (10.5%) showed a mild overall disability, 3 (0.8%) a moderate, and 1 (0.2%) a severe overall disability at discharge. A causative organism was detected in 65% (247/380) of patients. Staphylococcus aureus (S. aureus) was identified in 57.1% (141/247) of microbiological confirmed cases, including 1 (0.7%) methicillin-resistant S. aureus (MRSA) and 6 (4.2%) Panton-Valentine leukocidin (PVL)-producing S. aureus, followed by Group A Streptococcus (18.2%) and Kingella kingae (8.9%). K. kingae and PVL production in S. aureus were less frequently reported than expected from the literature. Conclusion POAIs are associated with a substantial morbidity in European children, with S. aureus being the major detected pathogen. In one-third of patients, no causative organism is identified. Our observations show an urgent need for the development of a vaccine against S. aureus and for the development of new microbiologic diagnostic guidelines for POAIs in European pediatric hospitals.
Examining the Predictive Validity of the Grit Scale-Short (Grit-S) Using Domain-General and Domain-Specific Approaches With Student-Athletes

This paper contributes to the debate as to whether grit is best conceptualized and measured as a domain-specific or domain-general construct. In the field of sport psychology, grit has traditionally been conceptualized and measured as a domain-general construct, with the majority of studies using the Grit Scale-Short (Grit-S: Duckworth and Quinn, 2009) to assess grit and its relationships with an array of personality-, performance-, and health-related outcomes. To date, no studies have compared the predictive validity of domain-general and domain-specific versions of the Grit-S with athletes who operate in different achievement settings. In a sample of United Kingdom student-athletes (N = 326, 214 males, 112 females; Mage = 19.55 years, SD = 1.48 years), we examined the degree to which a domain-general version and two domain-specific versions of the Grit-S accounted for variance in two criterion variables that were either situated in an academic context (i.e., emotional exhaustion) or a sport context (i.e., competitive level). Results obtained from a series of hierarchical multiple regression analyses indicated that an academic-version of the Grit-S explained unique variance in academic emotional exhaustion beyond the variance explained by the domain-general version of the scale, and a sport-version of the Grit-S explained unique variance in competitive level beyond the variance explained by the domain-general version. Results support the adoption of domain-specific approaches to measure grit in specific achievement contexts. Our findings highlight the need for researchers to carefully consider the measurement approaches they adopt when studying grit in individuals who operate across different achievement settings.
Modeling Users' Cognitive Performance Using Digital Pen Features

Digital pen features model characteristics of sketches and user behavior, and can be used for various supervised machine learning (ML) applications, such as multi-stroke sketch recognition and user modeling. In this work, we use a state-of-the-art set of more than 170 digital pen features, which we implement and make publicly available. The feature set is evaluated in the use case of analyzing paper-pencil-based neurocognitive assessments in the medical domain. Most cognitive assessments, for dementia screening for example, are conducted with a pen on normal paper. We record these tests with a digital pen as part of a new interactive cognitive assessment tool with automatic analysis of pen input. The physician can, first, observe the sketching process in real-time on a mobile tablet, e.g., in telemedicine settings or to follow Covid-19 distancing regulations. Second, the results of an automatic test analysis are presented to the physician in real-time, thereby reducing manual scoring effort and producing objective reports. As part of our evaluation we examine how accurately different feature-based, supervised ML models can automatically score cognitive tests, with and without semantic content analysis. A series of ML-based sketch recognition experiments is conducted, evaluating 10 modern off-the-shelf ML classifiers (i.e., SVMs, Deep Learning, etc.) on a sketch data set which we recorded with 40 subjects from a geriatrics daycare clinic. In addition, an automated ML approach (AutoML) is explored for fine-tuning and optimizing classification performance on the data set, achieving superior recognition accuracies. Using standard ML techniques our feature set outperforms all previous approaches on the cognitive tests considered, i.e., the Clock Drawing Test, the Rey-Osterrieth Complex Figure Test, and the Trail Making Test, by automatically scoring cognitive tests with up to 87.5% accuracy in a binary classification task.
Dissection of Structural Reorganization of Wheat 5B Chromosome Associated With Interspecies Recombination Suppression

Chromosomal rearrangements that lead to recombination suppression can have a significant impact on speciation, and they are also important for breeding. The regions of recombination suppression in wheat chromosome 5B were identified based on comparisons of the 5B map of a cross between the Chinese Spring (CS) variety of hexaploid wheat and CS-5Bdic (genotype CS with 5B substituted with its homologue from tetraploid Triticum dicoccoides) with several 5B maps of tetraploid and hexaploid wheat. In total, two regions were selected in which recombination suppression occurred in cross CS × CS-5Bdic when compared with other maps: one on the short arm, 5BS_RS, limited by markers BS00009810/BS00022336, and the second on the long arm, 5BL_RS, between markers Ra_c10633_2155 and BS00087043. The regions marked as 5BS_RS and 5BL_RS, with lengths of 5 Mb and 3.6 Mb, respectively, were mined from the 5B pseudomolecule of CS and compared to the homoeologous regions (7.6 and 3.8 Mb, respectively) of the 5B pseudomolecule of Zavitan (T. dicoccoides). It was shown that, in the case of 5BS_RS, the local heterochromatin islands determined by the satellite DNA (119.2) and transposable element arrays, as well as the dissimilarity caused by large insertions/deletions (chromosome rearrangements) between 5BSs aestivum/dicoccoides, are likely the key determinants of recombination suppression in the region. Two major and two minor segments with significant loss of similarity were recognized within the 5BL_RS region. It was shown that the loss of similarity, which can lead to suppression of recombination in the 5BL_RS region, is caused by chromosomal rearrangements, driven by the activity of mobile genetic elements (both DNA transposons and long terminal repeat retrotransposons) and their divergence during evolution. It was noted that the regions marked as 5BS_RS and 5BL_RS are associated with chromosomal rearrangements identified earlier by С-banding analysis of intraspecific polymorphism of tetraploid emmer wheat. The revealed divergence in 5BS_RS and 5BL_RS may be a consequence of interspecific hybridization, plant genetic adaptation, or both.
Effects of Nutrient Levels on Microbial Diversity in Sediments of a Eutrophic Shallow Lake

Microorganisms can both indicate the water quality characteristics and the health of the aquatic environment, which have an important influence on the cycling of organic carbon, nitrogen (N), and phosphorus (P) in nature. In this study, we took Taihu Lake, a typical eutrophic lake in China, as the research object, and monitored the northern (Changzhou City) and southern (Changxing County) regions of Taihu Lake for three consecutive years (2019–2021), respectively. We also analyzed the microbial diversity in sediments, and then summarized the effects of different nutrient environments on microorganisms in the aquatic environment. The results showed that the pollution level in the northern part of Taihu Lake was higher than that in the southern region of Taihu Lake, where the pollution was mainly in summer (June–July). The pollution in the southern region of Taihu Lake is relatively stable between 2019 and 2021; the changes in the northern part of Taihu Lake are relatively significant. Microbial diversity in the study area was negatively correlated with the degree of eutrophication of water bodies; microbial abundance was positively correlated with nutrient levels. The functional difference analysis indicated that the microorganisms in the sediments of Taihu Lake in the study area were involved in the nutrient transport and transformation, and played an important role in the purification of the lake water body. This study reveals the relationship between water eutrophication and microbial diversity, and then provides a theoretical basis for the management of eutrophic lakes.
Sensitivity of Seated Subjects to Low Frequency Random Vibrations in the Vertical Direction. Subjective Approach Using Vibrations Representative of Earthmoving Machines

A study was conducted to compare various methods for evaluating complex vibrations. The two methods recommended by the Standard ISO 2631 were tested. A subjective equalization technique was used in which 10 seated subjects were asked to adjust the intensity of a test stimulus until they perceived a whole body sensation equivalent to a reference stimulus. The vibration stimuli were low frequency motions along the vertical axis and they were representative of earthmoving machines. They were compared to each other and to sinusoidal and third octave band random vibrations centred at the same frequencies. The results obtained indicate that the overall frequency weighting methods are the most appropriate for the evaluation of complex vibrations. The vertical weighting curve recommended by the Standard ISO 2631 produces suitable results.