Miracle-dz/UniFAR-FTUs huggingface dataset:
Up-regulation of hypoxia-inducible factor antisense as a novel approach to treat ovarian cancer

Ovarian cancer (OC) is estimated to kill ~14,000 women in the United States in 2019. Current chemotherapies to treat OC initially show therapeutic efficacy but frequently drug resistance develops, at which point therapies with alternative targets are needed. Herein, we are describing a novel approach to sensitize these tumors to standard chemotherapies by increasing the transcription of hypoxia-inducible factor antisense. Methods: Genome-wide Bru-seq analysis was performed to fully capture the nascent transcriptional signature of OC cells treated with the gp130 inhibitor, SC144. In vitro and in vivo analysis, including characterization of hypoxia and select protein expression, combination with standard of care chemotherapy and antitumor efficacy were performed to assess the biological activity of SC144 on induction of hypoxia in OC cells. Results: Bru-seq analysis of OVCAR8 cells treated with SC144 shows upregulation of hypoxia related genes. In addition, transcription of hypoxia-inducible factor antisense (HIF1A-AS2) was induced that in turn reduced expression of HIF-1α and simultaneously increased expression of NDRG1. Furthermore, we observed decreased protein levels of EGFR, Met, c-Myc, cyclin D1, MMP-2, MMP-9 and TF, and phosphorylation of Src and P130-cas. SC144-induced alterations of HIF-1α and NDRG1 were also confirmed in prostate cancer cells. Ciclopirox olamine (CPX) induces a cellular transcriptional profile comparable to SC144, suggesting a similar cellular mechanism of action between these two compounds. In addition, SC144 sensitized OC cells to olaparib, carboplatin and cisplatin, and shows better in vivo efficacy than CPX. Conclusion: Induction of hypoxic stress responses through inhibition of gp130 represents a novel approach to design effective anticancer treatments in combination with standard-of-care chemotherapy in OC and the efficacy reported here strongly supports their clinical development.
Chrysophyte cysts in 36 Canadian high arctic ponds

Chrysophyte stomatocysts were described from the surface sediments and other habitats (moss, rocks, and open water) of 36 ponds located on Cape Herschel, Ellesmere Island in the Canadian high Arctic (78°37'N). Thirty-five distinct stomatocyst types were described using scanning electron microscopy (SEM); 1 other cyst was common, but was not observed with SEM. Our study ponds were diverse limnologically and contained distinct cyst floras, but the cause(s) of the floristic differences are as yet unclear. Two ponds with extreme values of water chemistry (i.e. high salinity and low pH) supported unique cyst floras. Distinctive cyst floras were also observed in ponds with high nutrient input from nesting birds and/or with diverse microhabitats (e.g. moss banks), which may provide substrate for periphytic chrysophytes. Arctic pond cyst floras are typically less diverse than those from temperate regions. Highly ornamented cysts are also less common in arctic waters, but the reason for this is unknown. Stomatocysts could be used to augment paleolimnological research in arctic ponds, if the environmental factors controlling cyst distributions and possibly degree of ornamentation can be elucidated.
MorLog: Morphable Hardware Logging for Atomic Persistence in Non-Volatile Main Memory

Byte-addressable non-volatile memory (NVM) is emerging as an alternative for main memory. Non-volatile main memory (NVMM) systems are required to support atomic persistence and deal with the high overhead of programming NVM cells. To this end, recent studies propose hardware logging and data encoding designs for NVMM systems. However, prior hardware logging designs incur either extra ordering constraints or redundant log data. Moreover, existing data encoding designs are unaware of the characteristics of log data, resulting in writing unnecessary log bits.In this paper, we propose a morphable hardware logging design (MorLog) that only logs the data necessary for recovery and dynamically selects encoding methods with least write overhead. We observe that (1) only the oldest undo and the newest redo data in each transaction are necessary for recovery, and (2) the log data for clean bits are clean. The first motivates our morphable logging mechanism. This mechanism logs both undo and redo data for the first update to the data in a transaction, and then logs only redo data. Undo data are eagerly written to NVMM to ensure atomicity, while redo data are buffered in a volatile log buffer and L1 caches to write only the newest redo data to NVMM. The second motivates our selective log data encoding mechanism. This mechanism simultaneously encodes log data with different methods, and writes the encoded log data with the least write cost to NVMM. We devise a differential log data compression method to exploit the characteristics of log data. This method directly discards clean bits from log data and compresses remained dirty bits. Our evaluation shows that MorLog improves performance by 72.5%, reduces NVMM write traffic by 41.1%, and decreases NVMM write energy by 49.9% compared with the state-of-the-art design.
Increased lipogenesis in cancer

Cancer cells have adapted an altered metabolism to support their dysregulated proliferation. In human carcinoma, upregulation of several key enzymes involved in lipid synthesis is associated with tumor cell aggressiveness and a poor patient diagnosis. The phenomenon of elevated lipogenesis and lipogenic machinery in tumor cells has suggested lipogenic enzymes as potential diagnostic markers and therapeutic targets for cancer.
The thalamus of the dolphin (Tursiops truncatus) and comparison with other mammals

The understanding of the direction of phylogenetic trends in the development of the mammalian forebrain has been sought with increasing intensity in recent years. The thalamus has been of particular interest since it constitutes an important key f o r understanding of the development of the cerebral cortex. I t also provides an indirect method for homologizing cortical fields because its nuclei in different mammals are morphologically often much easier to identify than are the respective cortical fields upon which these nuclei pro ject. The thalamus of a number of mammalian orders has not been described and the existing descriptions usually refer to animals with small brain and body weight;. The Cetacea are of particular interest because they are extremely specialized, and because they possess large brains with an apparently highly developed cerebral cortex. The purpose of this paper is to present a description of the cytoarchitecture of the dolphin thalamus with an emphasis on three questions. First, to consider to what extent the specialization of the dolphin is related
Variability in Removal of Dissolved Organic Carbon in Hyporheic Sediments

Dissolved organic carbon (DOC) is consumed by microbial metabolism as streamwater perfuses through a lateral gravel bar of the East Branch of the Wappinger Creek. The rate of DOC removal was estimated from the decline in DOC and travel time through the bar. Variability in DOC removal together with potential regulatory factors was determined for 14 dates spanning more than a 2-y period. DOC removal was not correlated with temperature, availability of oxygen, or residence time within hyporheic sediments. Hyporheic DOC could be predicted (r2 = 0.68) from streamwater DOC concentrations, with a surprisingly constant 57% (±9% [1 SD]) removal of DOC. This pattern suggests an initial concentration-dependent adsorption of DOC onto surfaces. This mechanism allows for efficient retention of DOC within hyporheic sediments even under conditions (low temperature, high interstitial velocity) that might be expected to minimize biotic consumption of DOC.
Insecticidal efficiency and safety of zinc oxide and hydrophilic silica nanoparticles against some stored seed insects

The present study was conducted to evaluate the insecticidal efficiency and safety of zinc oxide nanoparticles (ZnO NPs) and hydrophilic silica nanoparticles (SiO2 NPs) against: adults of rice weevil (Sitophilus oryzae L.); red flour beetle (Tribolium castaneum Herbst.) and cowpea beetle (Callosobruchus maculatus F.) results showed that, both ZnO NPs and hydrophilic SiO2 NPs exhibited a significant toxic effect (df, F and p < 0.5) against S. oryzae and C. maculatus at the highest concentration while T. castaneum showed high resistance against the two tested materials. At the end of the experiment, recorded mortality was: 81.6, 98.3 and 58.3% at the highest concentration used for each insect (0.3, 2 and 8 gm ⋅ kg–1 of SNPs with C. maculatus, S. oryzae and T. castaneum, respectively), while mortality was 88.3, 100 and 38.3% at the highest concentration used for each insect (0.6, 2.5 and 8 gm ⋅ kg–1 of ZnO NPs with C. maculatus, S. oryzae and T. castaneum, respectively). Both tested materials caused high reductions in F1-progeny (%) with C. maculatus and S. oryzae. Histopathological examination of male mice livers showed hepatic architecture with congested blood sinusoids, binucleated hepatocytes nuclei, dilated central vein and margainated chromatin in some nuclei. Histopathological assessment of the lungs showed normal histoarchitecture. There were no differences in alveolar septa, bronchiolar and epithelium of the treated and untreated animals. Silica and zinc oxide nanoparticles have a good potential to be used as stored seed protectant alternatives if applied with proper safety precautions.
Effects of using Casio FX991 ES PLUS on achievement and anxiety level in Mathematics

Mathematics anxiety has been a subject of research across levels. This study aimed at checking the effects of using Casio FX991ES Plus on the achievement and anxiety level of selected college students in a chartered local university in Manila, Philippines. Researchers employed the quasi-experimental research design. There were two groups of respondents in this experiment namely: control group who utilized traditional lecture method while the experimental group used the Casio FX991ES Plus Calculator. Both groups were exposed to the same lessons in Fundamentals of Statistics particularly topics in Inferential Statistics. Diagnostic test was administered to both groups to establish equal footing in terms of their abilities. This first researcher handled both the experimental and control groups. Results revealed that the experimental group performs significantly better as regards to the mean score in the achievement test. It can be concluded that their performance is greatly influenced by the use of calculator. In terms of anxiety level, both groups revealed significant difference in the pre and post tests. Although both are significant, it is noteworthy that there is a marked improvement in anxiety level under experimental group as manifested by a greater increased in result. An increase in the score means a reduction in the anxiety level. -
Modelling the distribution of the Boid snakes, Epicrates cenchria alvarezi and Boa constrictor occidentalis in the Gran Chaco (South America)

The viviparous snake species Epicrates cenchria alvarezi and Boa constrictor occidentalis inhabit the Gran Chaco region of South America. Ecological factors determining their distribution are poorly known. GIS-based modelling of a species' environmental requirements using occurrence records provides essential information of the species' distribution. We modelled the geographical distribution of E. c. alvarezi and B. c. occidentalis in the Gran Chaco and analyzed the degree to which their distribution is associated with different environmental variables (precipitation, normalized difference vegetation index (NDVI), land surface temperature and altitude) using Logistic Regression Analysis. We found that E. c. alvarezi and B. c. occidentalis would be more frequent in areas with high levels of NDVI (positive relationship with NDVI1), with low levels of precipitation (negative relationship with PRE1) and with lower altitude (negative relationship with ALT). However, the analysis also revealed specific differences in the environmental requirements of the snakes, showing that B. c. occidentalis is more frequent than E. c. alvarezi at sites with higher levels of NDVI. Additionally, E. c. alvarezi is more frequent at sites with lower temperatures in the dry season. The maps obtained show that both are highly likely to be present in the Dry subregion of the Gran Chaco. The results of the present study can be an important contribution to a better understanding of the ecological requirements of the species and of the impact of global environmental change on its distribution.
National Proceedings: Forest and Conservation Nursery Associations-2007

Protecting planted western redcedar (Thuja plicata) seedlings from deer browse in the Pacific Northwest and British Columbia is estimated to cost up to CAN$ 25 million annually. Recent studies linking deer browse and needle monoterpenes has resulted in the initiation of a breeding program for deer-resistant western redcedar at Cowichan Lake Research Station on Vancouver Island. Selections that are not preferred by deer are currently going through Ònon-preferredÓ rapid breeding and testing cycles for enhanced needle monoterpene concentrations. However, planting stock with increased monoterpene concentrations through genetic manipulation selection and breeding alone may not ensure that seedlings will be adequately protected from browse if deployment strategies are not carefully considered. To provide more robust protection to allow seedlings to reach the free-growing stage, iInteractions must be evaluated of between genetic selection for enhanced monoterpene concentrations,ally enhanced plants with Introduction Deer and elk browsing on newly planted western redcedar (Thuja plicata) seedlings in the Pacific Northwest (PNW) can result in delayed regeneration and potential plantation failure. As a result, CAN$ 20 to 25 million are spent annually in British Columbia to bring a plantation to free-to-grow status using individual tree guards (van Nienjenhuis 2007). Licensees who avoid planting western redcedar incur additional indirect costs, including maladapted or inappropriate species selection, and reduced manufacturing opportunities. The role of plant secondary metabolites (PSM) in plant defenses has long been recognized (Coley and Barone 1996; Huber and others 2004). Monoterpenes, a group of PSM, have been shown to reduce herbivore predation, including ungulate feeding (for example, Duncan and others 1994; Vourc’h and others 2002a). Plants contain both beneficial and deleterious phytochemicals that impact palatability and diet selection for ungulates (Kimball and Provenza 2003). developmental stage (ontogeny), and nutritional quality, as well as appropriate deployment strategies that allow deer some level offorage choice, could ensure adequate protection from browse.
Focused Value Prediction* : Concepts, techniques and implementations presented in this paper are subject matter of pending patent applications, which have been filed by Intel Corporation

Value Prediction was proposed to speculatively break true data dependencies, thereby allowing Out of Order (OOO) processors to achieve higher instruction level parallelism (ILP) and gain performance. State-of-the-art value predictors try to maximize the number of instructions that can be value predicted, with the belief that a higher coverage will unlock more ILP and increase performance. Unfortunately, this comes at increased complexity with implementations that require multiple different types of value predictors working in tandem, incurring substantial area and power cost.In this paper we motivate towards lower coverage, but focused, value prediction. Instead of aggressively increasing the coverage of value prediction, at the cost of higher area and power, we motivate refocusing value prediction as a mechanism to achieve an early execution of instructions that frequently create performance bottlenecks in the OOO processor. Since we do not aim for high coverage, our implementation is light-weight, needing just 1.2 KB of storage. Simulation results on 60 diverse workloads show that we deliver 3.3% performance gain over a baseline similar to the Intel Skylake processor. This performance gain increases substantially to 8.6% when we simulate a futuristic up-scaled version of Skylake. In contrast, for the same storage, state-of-the-art value predictors deliver a much lower speedup of 1.7% and 4.7% respectively. Notably, our proposal is similar to these predictors in performance, even when they are given nearly eight times the storage and have 60% more prediction coverage than our solution.
Chinese Aid and Health at the Country and Local Level

We investigate whether and to what extent Chinese development finance affects infant mortality, combining 92 demographic and health surveys (DHS) for a maximum of 53 countries and almost 55,000 sub-national locations over the 2002-2014 period. We address causality by instrumenting aid with a set of interacted variables. Variation over time results from indicators that measure the availability of funding in a given year. Cross-sectional variation results from a sub-national region’s “probability to receive aid. ” Controlled for this probability in tandem with fixed effects for country-years and provinces, the interactions of these variables form powerful and excludable instruments. Our results show that Chinese aid increases infant mortality at sub-national scales, but decreases mortality at the country-level. In several tests, we show that this stark contrast likely results from aid being fungible within recipient countries.
The Impact of External Business Environment on Corporate Social Responsibility: Theoretical Implications and Empirical Evidence

The literature evidently demonstrates the CEO-centric effect upon firms’ Corporate Social Responsibility (CSR) engagements. Given the CEO’s strong discretionary power over CSR decisions and self-serving motive divergent from shareholder value maximization, it would be interesting to investigate the strategic decisions made by the CEO on CSR policy facing varied dimensions of market conditions. From an agency theory perspective, the paper develops a theoretical framework to model and clarify the relationships between firm’s CSR provisions and the three dimensions of external market conditions: market complexity, munificence, and dynamism. Furthermore, I empirically measure the market dimensions and test the propositions implied by the theoretical work. Consistent with the model implications, I found CEOs tend to invest more in CSR in a competitive market, less in CSR when the market is munificent and more in CSR when the market is dynamic and unpredictable. The results are consistent with the extant literature and shed light on the value relevancy of CSR activities.
Fill effect of concentrates in the rumen of sheep

Dans un essai en carre latin avec huit moutons, dont quatre fistules du rumen, l'effet de quatre rations (H = foin seul; HB = foin + orge; HW = foin + ble; HP = foin + pulpe de betterave) a ete etudie sur les quantites de MS ingerees par jour, la quantite de contenu ruminal et les caracteristiques physicochimiques du contenu ruminal. Les apports de 700 g de concentre ont ete equivalents a 32%, en moyenne, de la MS totale ingeree des rations HB, HW, et HP. L'ingestion de foin seul a ete egale a 66g de MS/kg P 0.75 et les taux de substitution fourrage/concentre ont ete egaux respectivement a 0,48, 0,42 et 0,63. A la fin du grand repas, les quantites de contenus ruminaux frais ont ete identiques quelle que soit la ration (13,1 kg pour des moutons de 70 kg), en liaison avec un effet physique du concentre dans l'arret de l'ingestion. Les temps de sejour estimes des residus digestifs des concentres ont ete respectivement de 8, 4 et 9 heures, la valeur pour l'orge incluant probablement une augmentation des residus issus du foin. En fin de nuit, il a ete observe une tendance a ce que le rumen soit moins rempli lorsque les animaux recevaient des aliments concentres. Il est donc peu probable que les residus digestifs des concentres aient ensuite limite l'ingestion entre les grands repas.
An insight Review on Bacteriophage with emphasis on its application in Veterinary Medicine

Bacteriophages are naturally-occurring viruses that can infect and kill bacteria. They are remarkably diverse, numerous and widespread. Each phage has a narrow host range yet a large majority of bacteria studied so far play host to bacteriophages, hence the remarkable phage diversity. Phages were discovered just over 100 years ago and they have been used for treatment of bacterial infections in humans and other animals since the 1920s. While infecting bacterial host, they promote bacteria destruction, holding therefore a highly efficient antimicrobial activity. During the past years, bacteriophages have been applied and used as valuable tool in microbiological diagnostics and basic research. Even though the potential of bacteriophages for fighting bacterial pathogens is known for a long time, the phage therapy is not used in daily routine worldwide. Due to the continuing spread of bacterial resistance to antimicrobials and an increasing awareness of the necessity to protect consumers' health, the phage therapy meanwhile has become a subject of major interest in veterinary medicine, too. This article begins with a description of bacteriophages and explains why there has recently been a strong interest in their clinical use for treatment of bacterial infections, particularly those caused by organisms resistant to multiple antimicrobial compounds.
Dissolving the self

Psychedelic drugs such as psilocybin, LSD and DMT are known to induce powerful alterations in phenomenology. Perhaps of most philosophical and scientific interest is their capacity to disrupt and even “dissolve” one of the most primary features of normal experience: that of being a self. Such “peak” or “mystical” experiences are of increasing interest for their potentially transformative therapeutic value. While empirical research is underway, a theoretical conception of the mechanisms underpinning these experiences remains elusive. In the following paper, psychedelic-induced ego-dissolution is accounted for within an active inference framework, as a collapse in the “temporal thickness” of an agent’s deep temporal model, as a result of lowered precision on high-level priors. The argument here is composed of three moves: first, a view of the self-model is proposed as arising within a temporally deep generative model of an embodied organism navigating an affordance landscape in the service of allostasis. Next, a view of the action of psychedelics as lowering the precision of high-level priors within the generative model is unpacked in terms of a high Bayesian learning rate. Finally, the relaxation of high-level priors is argued to cause a “collapse” in the temporal thickness of the generative model, resulting in a collapse in the self-model and a loss of the ordinary sense of being a self. This account has implications for our understanding of ordinary self-consciousness and disruptions in self-consciousness present in psychosis, autism, depression, and dissociative disorders. The philosophical, theoretical and therapeutic implications of this account are touched upon.