Miracle-dz/UniFAR-FTUs huggingface dataset:
What determines omnivores’ meat consumption and their willingness to reduce the amount of meat they eat?

Background: Some meat eaters are faced with a dilemma: they like to eat meat, but they are also concerned about animal welfare, the environmental impact of meat production, and health risks associated with meat consumption. Aim We investigated the interrelationship between ‘meat attachment’ (people's affective connection towards meat) and the ‘4Ns’ (four defence arguments omnivores use to justify their meat consumption: eating meat is normal, necessary, nice, and natural), two constructs often used by researchers to measure omnivores justifications for meat consumption. Second, we compared the predictive power of both constructs on omnivores’ (willingness to reduce) meat consumption in a regression model that also included age, gender, educational level, financial status, and participants’ beliefs concerning environmental, ethical and health issues of eating meat. Methods: In total 203 Belgian omnivores (47.4% men) completed an online questionnaire in February 2020. Their ages ranged from 18 to 55 (M = 23.57, SD = 4.64). Results: Results indicate that the correlations between the different dimensions of ‘meat attachment’ and the 4Ns are significantly positive (p < 0.001). A comparison of the predictive power of both constructs on omnivores’ (willingness to reduce) meat consumption showed that the ‘meat attachment’ construct performs statistically better than the 4Ns construct. In addition, omnivores’ beliefs concerning the ethical implications of eating meat are also an important predictor in their meat consumption, whereas environmental and health related aspects are not. Conclusions: Our findings suggest that national health campaigns warning about the health risks of excessive meat consumption might be less effective than health campaigns focussing on the ethical issues associated with meat eating.
Association of Psychiatric Comorbidities With Treatment and Outcomes in Pediatric Migraines.

BACKGROUND AND OBJECTIVES Migraine headache is a common disorder in pediatrics, sometimes leading to hospital admission. Psychiatric comorbidities are prevalent in adults with migraine headache, but there is limited evidence in the pediatric population. This study aimed to examine the prevalence of psychiatric comorbidity in children hospitalized for migraine headache and assess the association of this comorbid state on treatment interventions and outcomes. METHODS This multicenter, retrospective cohort study examined data from the Pediatric Health Information System. Subjects included patients aged 6 to 18 hospitalized for migraine headache between 2010 and 2018, excluding those with complex chronic conditions. Associations of psychiatric comorbidity with treatments, length of stay (LOS), cost, and 30-day readmissions were assessed using the Fisher-exact, Wilcoxon-rank-sum test, and adjusted linear or logistic regression models. RESULTS The total 21 436 subjects included 6796 (32%) with psychiatric comorbidity, with prevalence highest for anxiety (2415; 11.2%), depression (1433; 6.7%), and attention-deficit/hyperactivity disorder (1411; 6.5%). Patients with psychiatric comorbidity were significantly more likely (P < .001) to receive dihydroergotamine (61% vs 54%), topiramate (23% vs 18%), and valproate (38% vs 34%), and have longer mean LOS (2.6 vs 2.0 days), higher average costs ($8749 vs $7040), and higher 30-day readmission (21% vs 17%). CONCLUSIONS Of children hospitalized for migraine headache, 32% have comorbid psychiatric disorders associated with increased use of medications, longer LOS, and increased cost of hospitalization and readmission. Prospective studies are recommended to identify optimal multidisciplinary care models for children with migraine headaches and psychiatric comorbidities in the inpatient setting.
β‐Glucan receptors on IL‐4 activated macrophages are required for hookworm larvae recognition and trapping

Recent advances in the field of host immunity against parasitic nematodes have revealed the importance of macrophages in trapping tissue migratory larvae. Protective immune mechanisms against the rodent hookworm Nippostrongylus brasiliensis (Nb) are mediated, at least in part, by IL‐4‐activated macrophages that bind and trap larvae in the lung. However, it is still not clear how host macrophages recognize the parasite. An in vitro co‐culture system of bone marrow‐derived macrophages and Nb infective larvae was utilized to screen for the possible ligand–receptor pair involved in macrophage attack of larvae. Competitive binding assays revealed an important role for β‐glucan recognition in the process. We further identified a role for CD11b and the non‐classical pattern recognition receptor ephrin‐A2 (EphA2), but not the highly expressed β‐glucan dectin‐1 receptor, in this process of recognition. This work raises the possibility that parasitic nematodes synthesize β‐glucans and it identifies CD11b and ephrin‐A2 as important pattern recognition receptors involved in the host recognition of these evolutionary old pathogens. To our knowledge, this is the first time that EphA2 has been implicated in immune responses to a helminth.
Inhibition of Full Smooth Muscle Contraction in Isolated Human Detrusor Tissues by Mirabegron Is Limited to Off-Target Inhibition of Neurogenic Contractions

Mirabegron is used for treatment of storage symptoms in overactive bladder (OAB) caused by spontaneous bladder smooth muscle contractions. However, owing to limitations in available studies using human tissues, central questions are still unresolved, including mechanisms underlying improvements by mirabegron and its anticontractile effects in the detrusor. Here, we assessed concentration-dependent mirabegron effects on contractions of human detrusor tissues in frequency-response curves and concentration-response curves for different cholinergic and noncholinergic agonists. Detrusor tissues were sampled from patients undergoing radical cystectomy. Contractions were induced by electric field stimulation (EFS) and by cumulative concentrations of cholinergic agonists, endothelin-1, and the thromboxane A2 analog U46619. EFS-induced contractions were inhibited using 10 µM mirabegron, but not using 1 µM. Inhibition by 10 µM mirabegron was resistant to the β3-adrenergic antagonist L-748,337. Concentration-dependent contractions by carbachol were not inhibited by 1 µM or 10 µM mirabegron. Concentration-response curves for methacholine were slightly right-shifted by 10 µM, but not 1 µM mirabegron. Concentration-dependent contractions by endothelin-1 or U46619 were not changed by mirabegron. In contrast, the muscarinic antagonist tolterodine right-shifted concentration-response curves for carbachol and methacholine and inhibited EFS-induced contractions. In conclusion, inhibition of neurogenic contractions in isolated detrusor tissues by mirabegron requires concentrations highly exceeding known plasma levels during standard dosing and the known binding constant (Ki values) for β3-adrenoceptors. Full contractions by cholinergic agonists, endothelin-1, and U46619 are not affected by therapeutic concentrations of mirabegron. Improvements of storage symptoms are most likely not imparted by inhibition of β3-adrenoceptors in the bladder wall itself. SIGNIFICANCE STATEMENT Mirabegron is used for overactive bladder (OAB) treatment, but the underlying mechanisms are unclear, and preclinical and clinical findings are controversial due to limitations in available studies. Our findings suggest that inhibition of detrusor contractions by mirabegron is limited to neurogenic contractions, which requires unphysiologic concentrations and does not involve β3-adrenoceptors. Mechanisms accounting for improvements of OAB by mirabegron are located outside the urinary bladder.
Role of SET oncoprotein in hepatocellular carcinoma: An immunohistochemical study

ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary cancer of the liver and it is the fourth most common cause of cancer related death worldwide. In Egypt, liver cancer constitutes the most common cause of mortality-related cancer. This study aimed to evaluate the immunohistochemical expression of SET oncoprotein in HCC tissues in comparison with its expression in non tumorous liver tissues and to correlate its expression with clinicopathological parameters. This study investigated 100 cases of HCC (including tumorous and non tumorous tissues). One hundred percent of tumorous and non-tumorous tissues were positive for SET expression. The mean and median values of H-score for SET expression were higher in tumorous than non tumorous tissues (P = .03). Higher SET expression was significantly correlated with larger tumor size (P = .012), positive lymphovascular invasion (P = .028), and shorter overall survival (P < .001). SET expression in tumor tissues is the most independent factor to affect the overall survival of HCC patients. SET plays a role in hepatocarcinogenesis proved by the increase of SET expression from non-tumorous to tumorous tissues. Also, SET can be used as a prognostic indicator and a novel target therapy in HCC patients
Investigation of lactic acid production by pressurized liquid hot water from cultivated Miscanthus × giganteus

Abstract The production of lactic acid, a polylactic acid monomer from energy crop Miscanthus × giganteus lignocellulosic biomass cultivated in Izmir was investigated. Liquid hot water (LHW) pretreatment was carried out at a temperature range of 140–200 °C, pressure 100 to 200 bar and reaction time of 15–45 min at a fixed flow rate of 2 mL/min using D-optimal experimental plan. The optimum conditions were elicited as 140 °C, 100 bar and 45 minutes, yielding the highest reducing sugar content of 77.32 mg/g, whereas 1.25 mg/mL arabinose and 1.35 mg/mL xylose as monomeric sugars. Subsequently, the enzymatic hydrolysis was applied to the solid fraction. The optimum conditions for enzymatic hydrolysis were determined as 5% (w/v) solid/liquid ratio, 20 FPU/mL enzyme loading and 72 hours, revealing the highest amount of reducing sugar as 200 mg/mL. LHW hydrolysate was used as a production medium for lactic acid manufacturing in submerged fermentation by Rhizopus oryzae. The maximum lactic acid content was found to be 6.8 g/L at 24 hours, whereas the lactic acid yield was 0.28 g/L.h. The sequential design of LHW, followed by enzymatic hydrolysis and submerged lactic acid fermentation can be utilized in industry, contributing to the bioeconomy.
The efficiency of autologous stem cell transplantation as the first-line treatment for nodal peripheral T-cell lymphoma: results of a systematic review and meta-analysis

ABSTRACT Background Nodal peripheral T cell lymphoma (PTCL) confers a dismal prognosis when treated with conventional chemotherapy. Autologous stem cell transplantation (ASCT) seems a reasonable alternative in eligible patients. Nevertheless, a consensus on the role of ASCT as the first-line consolidation therapy for nodal PTCL patients has not been reached so far. Methods A quantitative meta-analysis was performed via a systematic search in PubMed, Web of Science, Embase, and The Cochrane Library. The overall survival (OS), progression-free survival (PFS), hazard ratio (HR), and 95% confidence intervals (CIs) were compared and calculated from database inception to September 2021. Results Twelve articles were eligible. The results showed that ASCT could improve the survival of patients compared with chemotherapy alone. In terms of subtype analysis, results showed that angioimmunoblastic T cell lymphoma (AITL) patients could benefit more from chemotherapy followed by ASCT. Statistical differences were also confirmed for OS and PFS in different remission status, clinical stage, performance status (PS), chemotherapy regimen, and gender. Conclusion ASCT could serve as the first-line consolidation treatment strategy for nodal PTCL patients, especially AITL patients. Early clinical stage, good PS status, CR before transplantation, CHOEP regimen, and female patients may indicate a better outcome.
Mega‐fire in redwood tanoak forest reduces bacterial and fungal richness and selects for pyrophilous taxa that are phylogenetically conserved

Mega‐fires of unprecedented size, intensity and socio‐economic impacts have surged globally due to climate change, fire suppression and development. Soil microbiomes are critical for post‐fire plant regeneration and nutrient cycling, yet how mega‐fires impact the soil microbiome remains unclear. We had a serendipitous opportunity to obtain pre‐ and post‐fire soils from the same sampling locations after the 2016 Soberanes mega‐fire burned with high severity throughout several of our established redwood–tanoak plots. This makes our study the first to examine microbial fire response in redwood–tanoak forests. We re‐sampled soils immediately post‐fire from two burned plots and one unburned plot to elucidate the effect of mega‐fire on soil microbiomes. We used Illumina MiSeq sequencing of 16S and ITS1 sequences to determine that bacterial and fungal richness were reduced by 38%–70% in burned plots, with richness unchanged in the unburned plot. Fire altered composition by 27% for bacteria and 24% for fungi, whereas the unburned plots experienced no change in fungal and negligible change in bacterial composition. Pyrophilous taxa that responded positively to fire were phylogenetically conserved, suggesting shared evolutionary traits. For bacteria, fire selected for increased Firmicutes and Actinobacteria. For fungi, fire selected for the Ascomycota classes Pezizomycetes and Eurotiomycetes and for a Basidiomycota class of heat‐resistant Geminibasidiomycete yeasts. We build from Grime's competitor–stress tolerator–ruderal (C‐S‐R) framework and its recent microbial applications to show how our results might fit into a trait‐based conceptual model to help predict generalizable microbial responses to fire.
Evaluation of a pediatric pre-chemotherapy rapid hydration protocol: A quality assurance project

Introduction Intravenous hydration may be utilized to prevent nephrotoxicity and facilitate drug elimination in patients receiving high-dose chemotherapy. Prolonged hydration protocols may lead to delayed initiation and completion of therapy, lengthening hospital admissions. Rapid hydration protocols have been implemented to reduce the time required for patients to meet parameters for chemotherapy administration. This study aims to evaluate a rapid hydration protocol implemented at the Alberta Children's Hospital (ACH). Methods Starting January 2018 through May 2018, data was prospectively collected for pediatric oncology acute care and ambulatory patients at ACH receiving methotrexate (MTX), cisplatin, cyclophosphamide, or ifosfamide. The primary outcome was the time to achieve pre-determined urine parameters prior to chemotherapy administration. Secondary outcomes included the proportion of cycles that achieved urine parameters and the efficacy of each rapid hydration step. Results A total of 22 cycles were included, 13 for MTX and 9 for non-MTX chemotherapy. Median time to meet all urine parameters was 120 min (range 30–600 min). Two cycles (15%) failed rapid hydration in the MTX group, while no cycles required further hydration in the non-MTX group. Adverse events potentially attributable to hydration were mild and did not require intervention. Conclusion The ACH rapid hydration protocol resulted in reduced time to meet target urine parameters. The results of this quality assurance review support the continued use of rapid hydration prior to chemotherapy administration.
Probability Design of Bridge Truss Structure Based on Ansys

Aiming at structural design influence of part physical dimension and uncertainty of exterior load, response surface and several statistic parameter analyse of bridge truss structure bending stress and deflection was proceed by means of probability design and finite element method. FEM model was set up through parameter. Approximation function was constructed by response surface method. The probability design is more effective and more conformable to practical uses. 3figs. ,1tab. ,8refs.
Variation in Fetal Weight Percentile Estimates

Weight percentiles are generally reported without any indication of error. This variation can lead a fetus being mistakenly classified erroneously as having intrauterine growth restriction (IUGR) or macrosomia. The goal of this study was to compare estimated weight percentiles with the actual observed weight percentile for each gestational age in a large cohort of fetuses being scanned in our institution.
High viral load detection of human Cosavirus in Iranian pediatric patients with acute gastroenteritis.

Aim The present study implemented an RT-qPCR assay for the detection and quantification of human cosavirus in stool specimens from pediatric patients involved in acute gastroenteritis. Background Human cosavirus is a newly recognized virus that seems to be partly related to acute gastroenteritis in pediatric patients. However, the relationship between human cosavirus and diseases in humans is unclear. Methods From January 2018 to December 2019, a total of 160 stool samples were collected from pediatric patients presenting with acute gastroenteritis in a hospital in Karaj, Iran. After viral RNA extraction, RT-qPCR was performed to amplify the 5'UTR region of the human cosavirus genome and viral load was analyzed. Results The human cosavirus genomic RNA was detected in 4/160 (2.5%) stool samples tested. The maximum viral load was determined to be 4.6×106 copies/ml in one sample obtained from a 4-year-old patient. Conclusion The human cosavirus as a new member of the Picornaviridae family was illustrated in fecal samples from pediatric patients with acute gastroenteritis in Iran. This is the first documentation of human cosavirus circulation in Iranian children.
Molasses, Antox® and EN-FLORAX® decreased antibody decay rate and enhanced response to a very virulent infectious bursal disease virus and Newcastle disease vaccine La Sota in ISA Brown chicks

ABSTRACT This study evaluated the effects of molasses, Antox® and EN-FLORAX® on antibody (Ab) decay and response to a very virulent IBD virus (vvIBDV) and ND vaccine La Sota (NDVLS) in ISA Brown chicks. Five groups, (A, B, C, D and E) of 50 chicks each were used for the study. Groups A, B and C were supplemented with molasses, Antox® and EN-FLORAX®, respectively, orally from 1 to 49 days, and inoculated with a vvIBDV at 28 days of age. Groups D, and E were positive, and negative controls, respectively. At 35 days of age, all groups were vaccinated with NDVLS. Antibody (Ab) titers to vvIBDV, and NDV, were determined by indirect enzyme linked immunosorbent assay (I-ELISA), and hemagglutination-inhibition (HI) tests, respectively. Results revealed significantly (P < .05) decreased Ab decay rates in supplemented groups (A, B, and C) compared to controls (D and E) up to day 28. There were significantly (P < .05) higher mean IBDV and ND HI Ab titers in supplemented groups compared to D with the highest in A up to day 49. Molasses, Antox®, and EN-FLORAX® decreased rate of Ab decay, elicited stronger Ab response against vvIBDV and production of protective NDVLS HI Ab titers.
Seasonality of influenza and other respiratory viruses

In virology, the term seasonality describes variations in virus prevalence at more or less regular intervals throughout the year. Specifically, it has long been recognized that outbreaks of human influenza viruses, respiratory syncytial virus (RSV), and human coronaviruses occur in temperate climates during the winter season, whereas low activity is detected during the summer months. Other human respiratory viruses, such as parainfluenza viruses, human metapneumoviruses, and rhinoviruses, show highest activity during the spring or fall season in temperate regions, depending on the virus and subtype. In tropical climates, influenza viruses circulate throughout the year and no distinct seasonal patterns are observed, although virus outbreaks tend to spike during the rainy season. Overall, seasonality is more pronounced with greater distance from the equator, and tends to be less pronounced in regions closer to the equator (Li et al, 2019).
Antidepressant use during pregnancy and risk of adverse neonatal outcomes: A comprehensive investigation of previously identified associations

Prenatal antidepressant use is widespread. Observational studies have investigated the neonatal effects of prenatal antidepressant exposure with inconclusive results. We aimed to comprehensively investigate the associations between prenatal antidepressant exposure and the most commonly studied adverse neonatal outcomes: preterm birth, birthweight, poor neonatal adaptation, persistent pulmonary hypertension of the neonate (PPHN), neonatal admission and congenital malformations.
Neural correlates of affective empathy in aging: A multimodal imaging and multivariate approach

ABSTRACT Empathy is one such social-cognitive capacity that undergoes age-related change. C urrently, however, not well understood is the structural and functional neurocircuitry underlying age-related differences in empathy. This study aimed to delineate brain structural and functional networks that subserve affective empathic response in younger and older adults using a modified version of the Multifaceted Empathy Task to both positive and negative emotions. Combining multimodal neuroimaging with multivariate partial least square analysis resulted in two novel findings in older but not younger adults: (a) faster empathic responding to negative emotions was related to greater fractional anisotropy of the anterior cingulum and greater functional activity of the anterior cingulate network; (b) however, empathic responding to positive emotions was related to greater fractional anisotropy of the posterior cingulum and greater functional activity of the posterior cingulate network. Such differentiation of structural and functional networks might have critical implications for prosocial behavior and social connections among older adults.
Hypertension determinants among Ghanaians differ according to location of residence: RODAM study

Objective: Hypertension prevalence is high among African migrants, but the determinants of hypertension in migrants in Europe in relation to the population in the country of origin still needs to be elucidated. Therefore, the aim of this study was to assess the determinants of hypertension in Ghanaians residing in Ghana and Europe. Methods: The current study used baseline data of 5659 participants, aged 25–70 years, of the Research on Obesity and Diabetes among African Migrants study. Multivariate logistic regression analysis was used to assess sociodemographic, lifestyle, psychosocial, anthropometric and health factors independently associated with hypertension in Ghanaians living in rural and urban Ghana, and Ghanaian migrants living in Europe. Results: Across all sites, older age (both sexes; odds ratio 1.07, 95% confidence interval 1.06–1.08) and diabetes (females only; 2.02, 1.54–1.67) were independently associated with hypertension. The other determinants of hypertension differed between geographical locations. Higher waist circumference (1.12, 1.05–1.20) was independently associated with hypertension in rural-Ghanaian males, as was higher body mass index (1.15, 1.03– 1.28) in urban-Ghanaian males, higher waist circumference (1.04, 1.01–1.07) and diabetes (1.75, 1.17–2.63) in European-Ghanaian males. In European-Ghanaian females, high alcohol intake (1.88, 1.01 –3.53) and waist circumference (1.04, 1.02– 1.06) were associated with hypertension, whereas in rural-Ghanaian females, a higher educational level (0.28, 0.08–0.98) was inversely associated with hypertension. Conclusion: The current study identified several modifiable determinants of hypertension in Ghanaians, with differences between populations residing in various geographical locations. This highlights the importance of development and implementation of context-specific interventions targeting these determinants to reduce the burden of hypertension among Ghanaian migrants and nonmigrants.