Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigation of scour around the dual bridge piers under unsteady flow conditions using experimental model

The local scour around the bridge piers is the main cause of their destruction. Based on this, extensive studies have been done to understand this phenomenon. Most of these studies have been done under steady flow conditions. This is while the flow in the river is unsteady. Therefore, the experiments of this research were carried out under unsteady flow conditions. The purpose of this research is to investigate the scour around the dual bridge piers at different distances of the piers from each other in a uniform flow as well as unsteady flow using symmetric hydrographs. The hydrographs used in the experiments are stepped hydrographs in 5 steps. The experiments were conducted under clear water conditions and U/UC=0.95. In all experiments, the diameter of the bridge pier (D) was constant and equal to 2.5 cm. The center-to-center distance between the dual bridge piers (S) was selected as 2D, 3D, 4D and 5D. In the unsteady flow, with increasing relative distance between the dual bridge piers, the maximum dimensionless scour depth of the first and second piers was increased and its maximum was measured at a relative distance of S/D=5 (in the range of relative distances studied in the research). But in the uniform flow, the maximum dimensionless scour depth of the first and second pier was observed at S/D=3 and S/D=4, respectively. Also, at a constant distance between the piers, increasing the peak and base flow of the hydrographs step-by-step, increased the maximum dimensionless scour depth of the first pier of dual bridge piers with an increasing rate. However, increasing the peak and base flow of the hydrographs step-by-step, increased the maximum dimensionless scour depth of the second pier with a decreasing and increasing rate, respectively.
Single agents vs combination chemotherapy in relapsed and refractory peripheral T‐cell lymphoma: Results from the comprehensive oncology measures for peripheral T‐cell lymphoma treatment (COMPLETE) registry

Single agents have demonstrated activity in relapsed and refractory (R/R) peripheral T‐cell lymphoma (PTCL). Their benefit relative to combination chemotherapy remains undefined. Patients with histologically confirmed PTCL were enrolled in the Comprehensive Oncology Measures for Peripheral T‐cell Lymphoma Treatment (COMPLETE) registry. Eligibility criteria included those with R/R disease who had received one prior systemic therapy and were given either a single agent or combination chemotherapy as first retreatment. Treatment results for those with R/R disease who received single agents were compared to those who received combination chemotherapy. The primary endpoint was best response to retreatment. Fifty‐seven patients met eligibility criteria. At first retreatment, 46% (26/57) received combination therapy and 54.5% (31/57) received single agents. At median follow up of 2 years, a trend was seen towards increased complete response rate for single agents versus combination therapy (41% vs 19%; P = .02). There was also increased median overall survival (38.9 vs 17.1 months; P = .02) and progression‐free survival (11.2 vs 6.7 months; P = .02). More patients receiving single agents received hematopoietic stem‐cell transplantation (25.8% vs 7.7%, P = .07). Adverse events of grade 3 or 4 occurred more frequently in those receiving combination therapy, although this was not statistically significant. The data confirm the unmet need for better treatment in R/R PTCL. Despite a small sample, the analysis shows greater response and survival in those treated with single agents as first retreatment in R/R setting, while maintaining the ability to achieve transplantation. Large, randomized trials are needed to identify the best strategy.
Triangle singularities in 
B¯0→χc1K−π+
 relevant to 
Z1(4050)
 and 
Z2(4250)

Z1(4050) and Z2(4250) observed in B¯0→χc1K-π+ by the Belle Collaboration are candidates of charged charmoniumlike states that minimally include two quarks and two antiquarks. While Z1(4050) and Z2(4250) have been interpreted as tetraquark states previously, we propose a completely different scenario based on a kinematical effect called the triangle singularity. We demonstrate that the triangle singularities cause in the χc1π+ invariant mass distribution resonancelike bumps that fit very well the Belle data. If these bumps are simulated by the Z1(4050) and Z2(4250) resonance excitations, the spin-parity of them are predicted to be 1- for Z1(4050) and 1+ or 1- for Z2(4250). The bump corresponding to Z1(4050) has a highly asymmetric shape, which the Belle data exactly indicate. We show that the asymmetric shape originates from an interplay between the triangle singularity and the opening of the X(3872)π+ channel near the triangle-singularity energy. This characteristic lineshape could be used to discriminate different interpretations of Z1(4050). An interesting prediction from interpreting Z1(4050) and Z2(4250) as the triangle singularities is that similar bumps caused by the same mechanisms possibly appear also in B¯0→J/ψK-π+ data; the already observed Zc(4200) corresponds to Z2(4250) of JP=1+.
Magnetic Monopole Search with the Full MoEDAL Trapping Detector in 13 TeV pp Collisions Interpreted in Photon-Fusion and Drell-Yan Production.

MoEDAL is designed to identify new physics in the form of stable or pseudostable highly ionizing particles produced in high-energy Large Hadron Collider (LHC) collisions. Here we update our previous search for magnetic monopoles in Run 2 using the full trapping detector with almost four times more material and almost twice more integrated luminosity. For the first time at the LHC, the data were interpreted in terms of photon-fusion monopole direct production in addition to the Drell-Yan-like mechanism. The MoEDAL trapping detector, consisting of 794 kg of aluminum samples installed in the forward and lateral regions, was exposed to 4.0 fb^{-1} of 13 TeV proton-proton collisions at the LHCb interaction point and analyzed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to or above the Dirac charge are excluded in all samples. Monopole spins 0, ½, and 1 are considered and both velocity-independent and-dependent couplings are assumed. This search provides the best current laboratory constraints for monopoles with magnetic charges ranging from two to five times the Dirac charge.
An lncRNA-miRNA-mRNA ceRNA network for adipocyte differentiation from human adipose-derived stem cells

Human adipose tissue-derived stromal stem cells (HASCs) represent a promising regenerative resource for breast reconstruction and augmentation. However, the mechanisms involved in inducing its adipogenic differentiation remain to be fully elucidated. The present study aimed to comprehensively investigate the expression changes in mRNAs, microRNAs (miRNAs) and long non-coding (lnc)RNAs during the adipogenic differentiation of HASCs, and screen crucial lncRNA-miRNA-mRNA interaction axes using microarray datasets GSE57593, GSE25715 and GSE61302 collected from the Gene Expression Omnibus database. Following pretreatment, differentially expressed genes (DEGs), miRNAs (DE-miRNAs) or lncRNAs (DE-lncRNAs) between undifferentiated and differentiated HASCs were identified using the Linear Models for Microarray data method. A protein-protein interaction (PPI) network was constructed for the DEGs based on protein databases, followed by module analysis. The ‘lncRNA-miRNA-mRNA’ competing endogenous RNA (ceRNA) network was constructed based on the interactions between miRNAs and mRNAs, lncRNAs and miRNAs predicted by the miRWalk and lnCeDB databases. The underlying functions of mRNAs were predicted using the clusterProfiler package. In the present study, 905 DEGs, 36 DE-miRNAs and 577 DE-lncRNAs were screened between undifferentiated HASCs and differentiated adipocyte cells. PPI network analysis demonstrated that LEP may be a hub gene, which was also enriched in significant module 5. LEP was predicted to be involved in the Janus kinase-signal transducer and activator of transcription signaling pathway, and the regulation of inflammatory response. The upregulation of LEP was regulated by downregulated hsa-miRNA (miR)-130b-5p and hsa-miR-23a-5p (or hsa-miR-302d-3p). These miRNAs also respectively interacted with RP11-552F3.9 (or RP11-15A1.7), ultimately forming the ceRNA axes. In conclusion, the present study revealed that the RP11-552F3.9 (RP11-15A1.7)-hsa-miR-130b-5p/hsa-miR-23a-5p (hsa-miR-302d-3p)-LEP interaction axes may be crucial for inducing the adipogenic differentiation of HASCs via involvement in inflammation.
Hidden self-energies as origin of cuprate superconductivity revealed by machine learning

Experimental data are the source of understanding matter. However, measurable quantities are limited and theoretically important quantities are often hidden. Nonetheless, recent progress of machine-learning techniques opens possibilities of exposing them only from available experimental data. In this article, the Boltzmann-machine method is applied to the angle-resolved photoemission spectroscopy spectra of cuprate superconductors. We find prominent peak structures both in normal and anomalous self-energies, but they cancel in the total self-energy making the structure apparently invisible, while the peaks make dominant contributions to superconducting gap, hence providing a decisive testimony for the origin of superconductivity. The relation between superfluid density and critical temperature supports involvement of universal carrier relaxation time associated with dissipative strange metals. The present achievement opens avenues for innovative machine-learning spectroscopy method.
Efficacy of nasal endoscopic dacryocystorhinostomy for chronic dacryocystitis

Background: This study aims to assess the efficacy and safety of nasal endoscopic dacryocystorhinostomy (NED) for patients with chronic dacryocystitis (CD). Methods: The following 7 electronic databases will be searched from inception to the present: Cochrane Library, EMBASE, MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database. In addition, the clinical trials registry and reference lists of included studies will also be searched. We will only include randomized controlled trials of NED for CD in this systematic review. Two review authors independently carry out the study selection, data extraction, and methodological quality assessment. Whenever it is possible, we will pool the data and conduct meta-analysis by using RevMan 5.3 software. Results: This study will evaluate the efficacy and safety of NED for patients with CD. The primary outcome includes success rate of ostial patency. The secondary outcomes consist of duration of surgery, quality of life, postoperative complications, and surgeon's comfort. Conclusion: The findings of this study may summarize the latest evidence of NED for patients with CD. PROSPERO registration number: PROSPERO CRD42019123664.
Comparison of oxcarbazepine efficacy and MHD concentrations relative to age and BMI

Abstract Genetic polymorphisms are related to the concentration and efficacy of oxcarbazepine (OXC). 10-Hydroxycarbazepine (MHD) is the major pharmacologically active metabolite of OXC, and it exerts an antiepileptic effect. This study aimed to explore the connection between the MHD concentration and genes such as ATP-binding cassette B1 (ABCB1), ATP-binding cassette C2 (ABCC2), UDP-glucuronosyltransferase-2B7 and sodium voltage-gated channel alpha subunit 2 (SCN2A), which participate in the antiepileptic function of OXC. Total 218 Chinese epileptic patients, were stratified into different groups according to their age, body mass index (BMI) and OXC efficacy. The genotypes of 7 single nucleotide polymorphisms in all subjects were determined by polymerase chain reaction-improved multiple ligase detection reaction assay. The MHD plasma concentration was detected by high-performance liquid chromatography and then standardized through dosage and body weight. In general, the ABCC2 rs2273697 mutant (P = .026) required a significantly higher standardized MHD concentration. For age groups, carriers of the ABCC2 rs2273697 mutant showed a significantly higher standardized MHD concentration than noncarriers in the juvenile group (P = .033). In terms of BMI, a significantly higher standardized MHD concentration was found in the ABCB1 rs2032582 mutant of the normal weight group (P = .026). The SCN2A rs17183814 mutant required a significantly higher OXC maintenance (P = .014) in the low-weight group, while lower OXC maintenance dose (P = .044) and higher standardized MHD concentration (P = .007) in the overweight group. The ABCC2 rs2273697 polymorphism was significantly associated with MHD plasma concentration in the whole patient cohort and in patients stratified by different ages, this finding provides potential theoretical guidance for the rational and safe clinical use of OXC.
Quantitative estimates of dietary intake in households of South Tarawa, Kiribati.

BACKGROUND AND OBJECTIVES Malnutrition is a public health problem especially among the Pacific Small Island developing nations. This study assessed malnutrition with dietary intakes in households of South Tarawa, Kiribati, a West Pacific Island Nation State. METHODS AND STUDY DESIGN A cross-sectional community-based study design was used. One hundred and sixty-one households were selected from Betio, Bikenibeu and Teaorereke towns using a systematic random sampling method. About 35% each of the households was selected from Bikenebue and Besio while 30.4% was selected from Teaoraeke. Family (including children) dietary surveys including 24- hour dietary recall were administered to assess adequacy of nutrient intakes and dietary diversity using Household Diet Diversity Scores. A 3-day weighed food record was collected on a sub-sample. Data were analysed using FoodWorks Pro 8 for nutrient intake and Statistical Product for Service Solution (SPSS) version 21 for descriptive statistics. RESULTS Sixty-one percent of the subjects had the lowest dietary diversity, 36.3% had a medium dietary diversity and only 2.7% had the highest dietary diversity. Based on the weighed food record results (n=29), male subjects of all age groups had adequate intakes of riboflavin, niacin, vitamin C, magnesium, iron and zinc, but had high intakes of protein and sodium; and low intakes of potassium and calcium. Female subjects had adequate intakes of vitamin C, iron, magnesium and zinc, but had high intakes of protein and sodium; and low intakes of potassium and calcium. CONCLUSIONS Across all groups, 61% of the adult Kiribati population studied showed low dietary diversity, and a high prevalence of multiple micronutrient deficiencies.
Residents’ perceptions of desired and perceived tourism impact in Hainan Island

ABSTRACT This research aims to investigate residents’ perceptions of tourism development by exploring the sub-dimensions of impacts. The theoretical and practical implications of the four constructs are presented based on the results of this study. The T-test and ANOVA analyses with a sample of residents from Hainan Island in China reveal significant differences between the residents’ desired and perceived tourism impacts. In addition, residents with different occupations have significantly different perceptions of tourism impacts. However, no significant difference was observed in the residents’ perceived tourism impacts for the three regions with varied levels of tourism development.
Parametrized post-Newtonian-Vainshteinian formalism for the Galileon field

Recently, an extension to the Parameterized Post-Newtonian (PPN) formalism has been proposed. This formalism, the Parameterized Post-Newtonian-Vainshteinian (PPNV) formalism, is well suited to theories which exhibit Vainshtein screening of scalar fields. In this paper we apply the PPNV formalism to the Quartic and Quintic Galileon theories for the first time. As simple generalizations of standard scalar-tensor field theories they are important guides for the generalization of parameterized approaches to the effects of gravity beyond General Relativity. In the Quartic case, we find new PPNV potentials for both screened and un-screened regions of spacetime, showing that in principle these theories can be tested. In the Quintic case we show that Vainshtein screening does not occur to Newtonian order, meaning that the theory behaves as Brans-Dicke to this order, and we discuss possible higher order effects.
A unified framework of SAGE and SONC polynomials and its duality theory

We introduce and study a cone which consists of a class of generalized polynomial functions and which provides a common framework for recent non-negativity certificates of polynomials in sparse settings. Specifically, this $S$-cone generalizes and unifies recent cones of polynomials that establish non-negativity upon the arithmetic-geometric inequality (SAGE cone, SONC cone). We provide a comprehensive characterization of the dual cone of the $S$-cone, which even for its specializations provides novel and projection-free descriptions. As applications of this result, we give an exact characterization of the extreme rays of the $S$-cone and thus also of its specializations, and we provide a subclass of functions for which non-negativity coincides with membership in the $S$-cone. Moreover, we derive from the duality theory an approximation result of non-negative univariate polynomials and show that a SONC analogue of Putinar's Positivstellensatz does not exist even in the univariate case.
A cross-sectional survey on patient safety culture in secondary hospitals of Northeast China

Objectives This study aims to investigate patient safety culture in secondary hospitals of Heilongjiang, Northeast China, and explore the implications of patient safety culture and practices through the perspectives of various healthcare workers. Methods A cross-sectional survey using the Safety Attitude Questionnaire (SAQ) was conducted to ascertain the status of patient safety culture in nine secondary hospitals across the six dimensions of the SAQ. Among the 900 staff members who were invited to participate, 665 completed the questionnaire. Descriptive statistics were used to calculate the general means and standard deviations of the patient safety culture dimensions and other numerical variables, and F-test and a multivariate regression analysis were used to statistically analyze the differences in perceptions of safety culture considering the differences in demographic characteristics. All statistical analyses were performed using SPSS v. 22.0. Results The respondents rated job satisfaction as the highest among all six dimensions of the SAQ, followed in order by teamwork climate, working conditions, and stress recognition (the lowest). There were significant differences among the dimensions of patient safety culture and other factors, such as gender, age, job position, and education. Compared with previous studies, teamwork climate and working conditions scores were quite high, while stress recognition score was very low. We also found differences in patient safety culture by demographic characteristics. Conclusions The findings revealed the patient safety culture attitudes of healthcare workers in secondary hospitals of Heilongjiang, and provided baseline data for related future research. This evidence may also help government health policymakers and hospital administrators understand related challenges and develop strategies to improve patient safety culture in secondary hospitals of China and perhaps also in other developing countries.
Shaping the nebulous enhancer in the era of high-throughput assays and genome editing

Since the 1st discovery of transcriptional enhancers in 1981, their textbook definition has remained largely unchanged in the past 37 years. With the emergence of high-throughput assays and genome editing, which are switching the paradigm from bottom-up discovery and testing of individual enhancers to top-down profiling of enhancer activities genome-wide, it has become increasingly evidenced that this classical definition has left substantial gray areas in different aspects. Here we survey a representative set of recent research articles and report the definitions of enhancers they have adopted. The results reveal that a wide spectrum of definitions is used usually without the definition stated explicitly, which could lead to difficulties in data interpretation and downstream analyses. Based on these findings, we discuss the practical implications and suggestions for future studies.
Association between CMV and Invasive Fungal Infections After Autologous Stem Cell Transplant in Lymphoproliferative Malignancies: Opportunistic Partnership or Cause-Effect Relationship?

Unlike allogeneic transplant, autologous stem cell transplantation (ASCT) represents a procedure with a low-risk of cytomegalovirus (CMV) symptomatic reactivation-infection/end-organ disease (CMV complications) and invasive fungal disease (IFD). However, novel drugs for the treatment of lymphoproliferative malignancies could cause an increase of such opportunistic infections, even after ASCT. To the best of our knowledge, there are no published data demonstrating an association between CMV and IFD in the autologous setting, while this association has been widely reported in allogeneic transplantation. We have reviewed our series of 347 ASCT in myeloma and lymphoma patients performed over a period of 14 years with the aim of investigating the descriptive and analytical epidemiology of bacterial, CMV and IFD complications, focusing on the association between CMV and IFD. Patients with myeloma have significantly fewer bacterial infections and IFD than patients with lymphoma, but a similar rate of CMV complications. Descriptive epidemiological data are consistent with the literature, indicating an overall incidence of 36%, 3.5% and 15.5% for bacterial infections, IFD and CMV complications, with a case mortality rate of 4%, 16.7% and 3.7%, respectively. A strong correlation between CMV and IFD exists, with 8 cases of IFD out of a total of 12 presenting a CMV complication. At multivariate analysis, a diagnosis of lymphoma, ≥3 previous treatment lines and age ≥60 years were found to be independent risk factors for IFD. Duration of neutropenia (ANC < 500/mm3) ≥7 days represents an independent risk factor for CMV complications, where neutropenia most likely represents a crude surrogate biomarker indicating a deeper and longer state of overall immunosuppression. From our data we conclude that (1) myeloma patients are at lower risk of bacterial infections and IFD as compared with lymphoma patients but are at equal risk of CMV complications, most likely as a consequence of a selective impact of bortezomib on Herpes Viruses infection control; (2) a significant association exists between CMV and IFD, although a possible cause-effect relationship remains to be determined; (3) IFD is a rare complication after ASCT but burdened by a mortality rate of about 17%, with peak rates in older lymphoma patients who underwent more intensive therapeutic regimens.