Miracle-dz/UniFAR-FTUs huggingface dataset:
THE PATIENTS OF TYPE II DIABETES MELLITUS AND HELICOBACTER PYLORI INFECTION

: Among the human being Helicobacter pylori is the most common bacterial infection. This study has a specific aim to associate Helicobacter pylori infection in patients of diabetes mellitus. The basic design of the study was observational methodical cross sectional. Sixty Nine subjects were studied from which, 30 were non diabetics and 39 were diabetics, and their disease was 1 year or more old. The serological diagnosis of Helicobacter pylori was made according to the test of Anti- Helicobacter pylori antibody. All diabetic patients’ Antral biopsies specifically were taken during endoscopy. It was specifically observed that the diabetics mean age was 48.9±9.86 years and on the contrary of non-diabetics was 47.9±9.16 years. Subject’s majority belonged to fifth and sixth decades. There was conspicuous male preponderance in both the diabetics and the non-diabetics group, more attributable to the selection bias. The samples of serum for almost all the subjects were examined for the presence of IgG against Helicobacter pylori. In 40% subjects the Helicobacter pylori was positive particularly in non-diabetics and 64.1% of diabetics X2= 3.96, p value=0.047 (p<0.05) which was the prevalence of Helicobacter pylori in diabetics is prominently greater as compared with non-diabetics. Histological analysis of antral biopsies was performed in all diabetics and comparison of the type of diabetes, duration of diabetes, and level of glycaemia and complications of diabetes were made in patients of diabetes with and deprived of Helicobacter pylori. According to this study IDDM patients had greater positivity (75%) as compared with those of NIDDM (67.6%). The mean duration with Helicobacter pylori of diabetes group was 7.85+3.93 years, and greater than that of diabetics deprived of Helicobacter pylori which was 5.83±2.52. The fasting blood sugar’s mean was 192±60.3 mg/dl in diabetics with the group of Helicobacter pylori and was greater than that of diabetics deprived of Helicobacter pylori group which was 167±37.1mg/dl. The mean post prandial blood sugar in diabetics with Helicobacter pylori group was 318±78.4mg/dl and was higher than that of diabetics deprived of Helicobacter pylori group in whom it was 280±49.7mg/dl. The 2 diagnostic modalities viz serological and histological recognition of Helicobacter pylori associated well with each other. It was revealed that serological diagnosis by Anti- Helicobacter pylori antibody test is 80% sensitive and 75% particular. The Helicobacter pylori prevalence is greater in diabetics than the non-diabetics. The Helicobacter pylori infection prevalence had no important connection with duration of diabetes, type of diabetes, glycaemia levels of diabetics and complications of diabetics. The serological diagnosis of H. pylori was made by Anti-Helicobacter pylori antibody test, by Biochem Immuno systems ITALIA SPA ELAGEN Helicobacter pylori IgG Kit This ELISA technique is 80% sensitive and 75% specific.
An Evaluation Method of Assessing the Low Back Muscle Fatigue in Manual Material Handling

Workers in certain industries are exposed to high labor-intensive tasks. Low back pain (LBP) is widespread among construction workers (Hildebrandt, 1995) and is extremely prevalent, with every adult having up to an 85% chance of experiencing LBP at least once during his or her lifetime. Back-related complaints are more costly than those from any other body part for Alberta work-related claims. Ergonomic principles in addition to the engineering considerations should be included in the design of work stations to minimize the risk of injury for employees. In this study, we assessed the low back muscle fatigue due to lifting tasks. The objective was to investigate the changes in muscle activity and kinematics of the human body caused by fatigue due to repetitive lifting tasks. Three healthy male volunteers with no recent back complications were asked to complete 3 cycles of lifting task at the Syncrude Centre of the Glenrose Rehabilitation Hospital. Each cycle involved lifting a 15lb window frame for 20 times. Self ‐ adhesive reflective markers were attached on the hands, trunk, and legs to measure displacements and rotation of the body parts while performing the task. Electromyography (EMG) sensors were placed on lower back muscles to record their activity. The muscle fatigue was investigated by studying change in EMG spectral parameters such as RMS, mean frequency (MNF), and median frequency (MDF) as well as physical condition of subjects due to repetitive lifting. The power frequency curve shifted to the low frequency when muscle fatigue occurred. As a result, the slope of the RMS, and MNF indicators were successful to describe the fatigue behavior expected.
in long-term e-cigarette and replacement therapy

Background: Given the rapid increase in e-cigarette (EC) popularity and paucity of longitudinal health- 26 related data associated with this, there is an urgent need to assess the potential risks of long-term EC use. 27 Objective : To compare exposure to nicotine, tobacco-related carcinogens and toxicants among cigarette-only 28 smokers, and smokers and ex-smokers with long-term EC use or with use of nicotine replacement therapy 29 (NRT; a product with known safety profile). 30 Design: Cross-sectional study. 31 Setting: United Kingdom. 32 Participants: Five groups were purposively recruited: (1) cigarette-only users, (2) ex-smokers with long-term 33 (≥6 months) EC-only or (3) NRT-only use, and (4) long-term dual cigarette-EC or (5) dual cigarette-NRT 34 users (N=36-37 per group, total N=181). Measurements: Socio-demographic and smoking characteristics were assessed; participants provided urine and saliva samples, analysed for biomarkers of nicotine, tobacco-specific nitrosamines (TSNAs) and volatile 37 organic compounds (VOCs). Results: After controlling for confounders, there were no clear group differences in salivary or urinary biomarkers of nicotine intake. EC-only and NRT-only users had significantly lower metabolite levels for 40 TSNAs (including the carcinogenic metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, NNAL) and 41 for VOCs (including metabolites of the toxicants acrolein, acrylamide, acrylonitrile, 1,3-butadiene, ethylene oxide) compared with cigarette-only, dual cigarette-EC or cigarette-NRT users. EC-only users had significantly lower NNAL levels than all other groups. Cigarette-only, dual cigarette-NRT and cigarette-EC users had largely similar levels of TSNA and VOC metabolites. Limitations: Cross-sectional design with self-selected sample. Conclusions: Ex-smokers with long-term EC-only compare ex-smokers as a function of EC use in real life settings. This study aimed to address the gap in the existing literature by measuring biomarker levels in long-term users of EC compared with an appropriate control, NRT users. Specifically, this study assessed whether long-term EC-only, NRT-only, dual cigarette-EC or dual cigarette-NRT use is associated with differences in metabolites of a) nicotine; b) TSNAs and c) volatile organic compounds (VOC) compared with cigarette-only smokers.
In-vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in de-novo CML patients.

Most de-novo CML patients achieve good responses to imatinib, but the rate and degree of molecular response is variable. We assessed the IC50 imatinib in 62 de-novo chronic phase CML patients as a predictor of molecular response. IC50 imatinib was determined in pre therapy blood samples by measuring the in-vitro imatinib-induced reduction of the phosphorylated form of the adaptor protein Crkl. There was marked variability between patients, with IC50 imatinib ranging from 0.375 to 1.8 u M (median 0.6 u M). Patients with low IC50 imatinib (IC50 (cid:1) 0.6 u M; n=36) had a 36% probability of achieving 2 log reduction in BCR-ABL by 3 months compared to 8% in high IC50 imatinib patients (n=26) (p=0.01). The IC50 imatinib was also predictive of molecular response at 12 months, with 47% of patients in the low IC50 imatinib group achieving 3 log reduction and 23% in the high IC50 imatinib group (p=0.03). The predictive power of IC50 imatinib was particularly strong in patients with low Sokal scores. This data provides strong evidence that intrinsic sensitivity to imatinib is variable in previously untreated CML patients, and the actual level of BCR-ABL kinase inhibition achieved is critical to imatinib response. The IC50 imatinib potentially provides a new prognostic indicator for molecular response in imatinib treated patients. (IC50 imatinib ) in 62 patients enrolled in the TIDEL trial; an Australasian Leukemia and Lymphoma Group (ALLG) study in which 102 de-novo CML patients were treated with 600 mg of imatinib as front line therapy. By correlating findings with molecular response over the first 12 months of treatment, we found that the pre-therapy IC50 imatinib provides a statistically significant predictor of patient outcome.
Biosorption of Cadmium by Mangrove-Derived Cyanobacteria ( Gloeocapsa sp ARKK3 )

Dried microbial biomass of Gloeocapsa sp. Trichoderma, and Thrustochytrids used as bioadsorbent for the removal of cadmium in the artificial sewage. Among the three species the maximum adsorption recorded in Gloeocapsa sp. biomass. For the augmentation of cadmium removal in sewage, adsorption process conditions was statistically optimized by the method of response surface methodology (RSM) and adsorption kinetics also studied. The important factors of temperature, pH, adsorbent dosage and processing time were selected for optimization, and it was done with 30 experimental cycles derived from centre composite design (CCD). The statistical optimization reveled that optimized condition for cadmium removal was pH 9, temperature 40ºC, adsorbent dosage 0.6 mg.l -1 and 60 minutes. Finally in this condition was experimentally proved with yield of cadmium removal of 92.9 % under statistically optimized condition. In the case of the adsorption kinetic Gloeocapsa sp. biomass showed a significant adsorption capacity of qmax-56.96 (mg.g -1 ). The present study concluded that the microbial dried biomass derived from marine Gloeocapsa sp. was a potent source for the removal of the cadmium in the sewage waste water.
The Surgical of Contracture Using Multiple Transverse Incisions.

Dupuytren’s contracture is a condition commonly encountered by hand surgeons, although it is rare in the Asian population. Various surgical procedures for Dupuytren’s contracture have been reported, and the outcomes vary according to the treatment modalities. We report the treatment results of segmental fasciectomies with multiple transverse incisions for patients with Dupuytren’s contracture. The cases of seven patients who underwent multiple segmental fasciectomies with multiple transverse incisions for Dupuytren’s contracture from 2006 to 2011 were reviewed retrospectively. Multiple transverse incisions to the severe contracture sites were performed initially, and additional incisions to the metacarpophalangeal (MCP) joints, and the proximal interphalangeal (PIP) joints were performed if necessary. Segmental fasciectomies by removing the fibromatous nodules or cords between the incision lines were performed and the wound margins were approximated. The mean range of motion of the involved MCP joints and PIP joints was fully recovered. During the follow-up periods, there was no evidence of recurrence or progression of disease. Multiple transverse incisions for Dupuytren’s contracture are technically challenging, and require a high skill level of hand surgeons. However, we achieved excellent correction of contractures with no associated complications. Therefore, segmental fasciectomies with multiple transverse incisions can be a good treatment option for Dupuytren’s contracture.
ERCC1 C118T POLYMORPHISM HAS PREDICTIVE RISK VALUE FOR BREAST CANCER IN PATIENTS RECEIVED PLATINUM-BASED CHEMOTHERAPY AS THE ADJUVANT TREATMENT

All study participants were asked to provide 2 mL venous blood, which was stored at -23°C until use, with EDTA used as an anticoagulant. Genomic DNA was extracted using the Relia Prep Blood gDNA Miniprep System (Promega/USA) according to manufacturer instructions. gDNA were verified by 1.0% agarose gel electrophoresis. PCR was conducted in a 20-µL reaction volume containing 250 ng genomic DNA. The PCR reaction started at 94°C for 3 min, followed with 40 cycles of 94°C for 30 s, the annealing temperature was reduced to 60°C for 1min. The correlation between and of was using odds ratios and their 95% confidence intervals (CIs). P < 0.05 was considered to be statistically significant. ABSTRACT We conducted a cohort study to investigate the role of 118 single-nucleotide polymorphisms of the excision repair cross complimentary group 1 (ERCC1) gene polymorphism in risk of breast cancer in Iraqi women. A total of 44 patients with breast cancer diagnosed participated in this study. ERCC1 rs11615 were genotyped. Individuals with the ERCC1 rs11615 CT genotype and the T allele showed a significant risk to breast cancer compared to the wild-type genotype. In conclusion, this study reports that the ERCC1 rs11615 CT polymorphism can be used as a prognostic marker to determine the risk of breast cancer patients treated with platinum base chemotherapy.
The Prediction of Student Performance in Chemistry-based Courses in Public Universities Using University Matriculation Entrance Scores in Chemistry

Human Ergonomics, Sustainment, Logistics, Supply Chain Management, Life cycle Systems, Systems Integration and Management of technology systems. Engineering & Greensboro peer reviewed publications to his belongs to a number of professional organi-zations such as the Institute of Industrial Engineers (IIE), Society for Engineering Management (SEM), Project Management Institute (PMI), Society for Health Systems (SHS) and Association of Technology Management and Applied Engineering (ATMAE). He is also a member of Alpha Pi Mu Kappa Phi Honors society.
Final Technical Report on NSF Grant DES 75-10719, "Tropical Wave Dynamics"

Solutions to the wave-CISK (conditional instability of the second kind with cumulus heating being induced by low-level internal wave convergence) system are obtained to study the vertical structure of marginally unstable waves. A diabatic heating profile is specified that resembles those observed and those theoretically derived from simple parameterization schemes. Upper and lower bounds for the vertical wavelength of the unstable waves under normal heating conditions are established through analysis of the frequency (stability) equation. The lower bound excludes the possibility of e.xcitation or maintenance of short vertical wavelengths (relative to the vertical scale of heating) by wave-CISK. The calculated growth rates indicate that this result is basically insensitive to the vertical heating profile. The vertical structure of the most unstable waves is also computed and the possible roles played by CISK in large-scale tropical waves are discussed in light of these results.
Role of Hysteroscopy in the Evaluation of Abnormal Uterine Bleeding

Introduction: Abnormal uterine bleeding(AUB) accounts for 30-40% of all gynaecological cases. Hysteros- copy allows direct visualisation of structural lesions within the endometrial cavity and can be performed as a diagnostic and therapeutic procedure in the same sitting. Objective: To assess the accuracy of the hysteroscopic diagnosis with that of hystopathological reports obtained by endometrial sampling. Materials and Methods: A prospective cross-sectional study in which hysteroscopy was performed for 50 patients with AUB. Hysteroscopy was done and after noting the findings, hysteroscope was withdrawn out of uterine cavity. Endometrial sampling was done. Then hysteroscope was reinserted and biopsy of persisting focal lesion was taken. Both sam- ples were sent for histopathology. Result of hysteroscopy and endometrial sampling were compared. Statistical analysis was done by calculating sensitivity and specificity of hysteroscopy versus histopathology by targeted hysteroscopic bi- opsy and endometrial sampling. Results: The mean age of the study group was 40.35±5.4 years(range 26-60 years). The mean parity was 3.2±1.5. The most common symptom was menorrhagia (40%) followed by metrorrhagia 38%, polymenorrhagia(12%) and postmenopausal bleeding(10%). The overall sensitivity and specificity of hysteroscopy for diagnosing intrauterine abnormalities was 84% and 72% respectively. Sensitivity and specificity of the procedure for endometrial hyperplasia was 66.6 and 90.2% respectively. For endometrial polyps, the results were 80% and 97.5% respectively. The sensitivity and specificity of the procedure was 100% for submucous fibroids and 100% and 95% respectively for inflammation. The sensitivity and specificity for atrophic endometrium was 100% and 95.9% respectively. Conclusion: Hysteroscopy is a valuable tool for diagnosing endometrial inflammation, atrophic endometrium and focal lesions like endometrial polyps and submucosal fibroids. However hysteroscopy is not very reliable diagnostic modality for endometrial hyperplasia.
University of Birmingham Higher education, career opportunities and intergenerational inequality

: The UK government has expressed a desire to increase social mobility, with policies to help achieve this aim focused on reducing inequalities in educational attainment. This paper draws together established and new information about the contribution that higher education can make to social mobility using a life-course approach, considering differences by family background in terms of university attendance and achievement, as well as occupation and earnings following graduation. We find substantial socio-economic differences at each stage. Young people from poorer backgrounds are, on average, less likely to go to university than their richer peers. Even among the selected group who do go to university, they are less likely to attend the highest status institutions, less likely to graduate, and less likely to achieve the highest degree classes. These differences in degree outcomes contribute to the lower average earnings of graduates from poorer families, but earnings differentials go well beyond those driven purely by degree attainment or institution attended. The evidence strongly suggests that, even after taking these factors into account, graduates from affluent families are more likely to obtain a professional job and to see higher earnings growth in the labour market. We discuss the implications of these findings for the prospects of higher education as a route to greater social mobility. of Leavers Cohort student period 2006–11
The $\textbf{nbc}$ minimal complex of supersolvable arrangements

In this paper we give a very natural description of the bijections between the minimal CW-complex homotopy equivalent to the complement of a supersolvable arrangement $\mathcal{A}$, the $\textbf{nbc}$ basis of the Orlik-Solomon algebra associated to $\mathcal{A}$ and the set of chambers of $\mathcal{A}$. We use these bijections to get results on the first (co)homology group of the Milnor fiber of $\mathcal{A}$ and to describe a bijection between the symmetric group and the $\textbf{nbc}$ basis of the braid arrangement.
Understanding and addressing the stigma of mental illness with

: Higher income societies have moved from institutional to community-based care for people experiencing mental illness. However, stigma and discrimination persists and undermines help-seeking, recovery and life chances. Mental illness prevalence is higher amongst communities that face multiple prejudices and disadvantages within society, including black and minority ethnic communities who may experience migration trauma, racism, acculturation and adverse social circumstances. This study examines beliefs, stigma and the effectiveness of existing national mental health campaigns with Pakistani, Indian and Chinese heritage communities in Scotland, UK, using community based participatory research. Community organisers were trained and supported to co-facilitate focus groups with 87 people using a range of languages. Whilst diversity within and between communities was apparent, important trends emerged. People with mental illness experience high levels of stigma from communities. Families experience signiﬁ cant associated stigma. This shame combines with culturally inappropriate services to reduce help seeking from mental health services, friends and families. Existing anti-stigma campaigns have failed to reach or engage with communities due to a combination of practical issues such as the use of inappropriate language, imagery and media, but also due to assuming western medical concepts of illness. Participants suggested a new model for national campaigns placing greater emphasis upon community development, cultural events, positive contact and dialogue with families, faith leaders and youth groups. National anti-stigma programmes must develop more effective partnerships with communities or risk magnifying existing inequalities.Despite a range of national programmes to address stigma towards people with mental illness, it remains as the major barrier to social inclusion for people with mental illness living in communities. Stigma is particularly severe if people have a mental illness and are also economically disadvantaged or face multiple stigmas. By adopting Community Based Participatory Research (CBPR) approaches with three black and ethnic minority communities in Scotland, this study makes the case that stigma can only be understood and effectively addressed with reference to its socio-cultural context. This study undertakes research with members of the three largest BME communities in Scotland that have migrated from China, Pakistan and India. We explored commonly held beliefs about mental patterns of stigma and discrimination and perceptions about the current national anti-stigma campaign in order to inform future action.
EXPERIMENTAL STUDIES Coxsackievirus B 3 Murine Myocarditis: A Pathologic Spectrum of Myocarditis in Genetically Defined Inbred Strains

Group B coxsackieviruses are the most frequent caus ative agents in human viral myocarditis. Susceptibility to viral infections varies widely among individuals. In the mouse, coxsackievirus B 3 also causes myocarditis. The differential susceptibility of different inbred strains of mice to coxsackieB 3-induced myocarditis also appears to be under genetic control. This study details the histo pathology of coxsackie B 3 myocarditis in six different inbred strains of micefor the first 45days after coxsackie B 3 infection. These strains differ either in the haplotypes of their major histocompatibility complex or in their background genome. re spect identified
Cellular Immune Responses during High-Dose Interferon- (cid:1) Induction Therapy for Hepatitis C Virus Infection Induction

Background. The effect that high-dose interferon (IFN)– (cid:1) induction therapy for hepatitis C virus (HCV) infection has on cellular immune responses is currently unknown. Methods. Thirty-one treatment-naive patients with chronic HCV infection received amantadine and ribavirin, combined with 6 weeks of high-dose IFN- (cid:1) -2b induction therapy followed by weekly pegylated IFN- (cid:1) -2b, for 24 or 48 weeks. Using IFN- (cid:2) and interleukin (IL)–2 enzyme-linked immunospot (ELISpot) assays, we analyzed the pattern of cytokine secretion by structural and nonstructural HCV- and cytomegalovirus (CMV)–speciﬁc T cells before, during, and after therapy. Results. HCV-speciﬁc T cell responses, which were predominantly IFN- (cid:2) secreting and which correlated with alanine transaminase levels ( r 2 (cid:3) 0.45; P (cid:3) . 001), were found before treatment in 10 of 15 patients with a sustained virological response (SVR) and in 11 of 16 in the non-SVR group. There was a striking loss of IFN- (cid:2) and IL-2 HCV-speciﬁc T cells during therapy, predominantly in the SVR group.