Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Four-Way Variant Translocation, t(1;9;22;16)(q21;q34;q11.2;q24), in a Patient with Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is characterized by the Philadelphia (Ph) chromosome resulting from the translocation of t(9;22)(q34;q11), producing the BCR::ABL1 fusion gene. Variant Ph chromosome translocations, involving rearrangements in chromosomes other than 9 and 22, occur in 5–10% of CML cases. Herein, we report a unique case of a 36-year-old male with a four-way variant Ph chromosome. Conventional chromosomal analysis performed on bone marrow aspirate samples showed 46, XY, t(1;9;22;16)(q21;q34;q11.2;q24). Nested RT-PCR of the BCR::ABL1 gene revealed a major BCR::ABL rearrangement. The treatment with nilotinib achieved a complete hematologic, cytogenetic, and molecular response after 12 months.
Analysis of Water Prices in Urban Systems: Experience from Three Basins in Southern Portugal

The economic analysis of water uses is one of the main components of river basin management plans (RBMP), as established by the Water Framework Directive. Thus the first-generation RBMP for Portuguese river basin districts (RBD) 6 – Sado/Mira, 7 – Guadiana and 8 – Ribeiras do Algarve included a thorough economic analysis of urban drinking water supply (WS) and wastewater drainage and treatment (WWDT) systems. This paper summarizes results on the role of prices, encompassing the assessment of cost-recovery levels, the discussion of tariff structures, the estimation of residential water-demand elasticities and an appraisal of affordability conditions. RBD7 had the lowest cost-recovery levels, namely in WWDT, but revenue was insufficient to guarantee financial equilibrium in all RBD. As for tariff structures, they were far from complying with the economic regulator’s recommendations or meeting economic efficiency criteria. The estimated residential water-demand elasticities indicate that climate change may have a strong impact on demanded quantity, whereas price has a significant but limited impact on moderating demand, illustrating the need for a combination of price and non-price policies. On the other hand, low price elasticities imply that price increases could be effective in writing off tariff deficits. Average household expenses with water services were still substantially lower than the OECD recommended threshold, although tariff increases need to be done in a way that ensures access to the poorer households.
Comparing Effectiveness and Safety of Intravenous Atropine with Topical Tetracaine in Preventing and Relieving Oculocardiac Reflex in Patients Undergoing Strabismus Surgery: A Randomized Clinical Trial

Abstract Background: Oculocardiac reflex (OCR) is one of the serious complications following surgical therapeutic procedures for strabismus. Various medications have been tested to prevent or mitigate this complication. We aimed to compare the effect of intravenous atropine and topical tetracaine on the incidence and severity of OCR in strabismus surgery. Materials and Methods: In this triple-blind randomized clinical trial study, 120 patients who were candidates for strabismus surgery were randomly assigned to receive intravenous atropine, topical tetracaine, or artificial tears as the control. The incidence of OCR and its severity along with the changes in hemodynamic conditions were compared across the groups. Results: The incidence rate of OCR in the groups receiving atropine, tetracaine, and the control was found to be 17.5%, 25.0%, and 32.5% in the releasing phase without any difference, respectively (P = 0.303); however, it was 2.5%, 7.5%, and 25.0%, respectively, in the cutting phase, indicating a lower rate in the group receiving tetracaine (P = 0.004). Similarly, there was no difference in the severity of OCR across the three study groups in the releasing phase (P = 0.666); however, in the cutting phase, OCR was revealed to be milder in the group receiving atropine as compared to other groups (P = 0.033). Prescribing atropine led to higher mean systolic blood pressure and mean arterial pressure during surgery. Conclusion: The injection of atropine can effectively reduce the incidence of OCR during strabismus surgery and reduce its severity if this reflex occurs.
Nanocellulose Composite Films in Food Packaging Materials: A Review

Owing to the environmental pollution caused by petroleum-based packaging materials, there is an imminent need to develop novel food packaging materials. Nanocellulose, which is a one-dimensional structure, has excellent physical and chemical properties, such as renewability, degradability, sound mechanical properties, and good biocompatibility, indicating promising applications in modern industry, particularly in food packaging. This article introduces nanocellulose, followed by its extraction methods and the preparation of relevant composite films. Meanwhile, the performances of nanocellulose composite films in improving the mechanical, barrier (oxygen, water vapor, ultraviolet) and thermal properties of food packaging materials and the development of biodegradable or edible packaging materials in the food industry are elaborated. In addition, the excellent performances of nanocellulose composites for the packaging and preservation of various food categories are outlined. This study provides a theoretical framework for the development and utilization of nanocellulose composite films in the food packaging industry.
Kankakee River Basin in Illinois: hydraulics, hydrology, river geometry, and sand bars interim report

This interim report summarizes the work completed within the first nine months of the project. This report summarizes all of the existing streamflow records for Illinois and for two stations from Indiana, lists the available literature, and describes the field trip to the site. Analyses of the bed and bank material samples collected during the field trip also are included. Maps of the bank lines from the Route 30 Bridge in Indiana to the confluence of the Kankakee River with the Des Plaines River have been completed and will be available with the final report. Bank conditions of the entire main stem of the Kankakee River from the Route 30 Bridge in Indiana to its confluence with the Des Plaines River are also summarized. This includes general bank conditions, shoreline stability, erosion sites and severity, pumping stations, log and tree jams, and other features. Additional work on the surveying of the river and sand bar geometries is now being done. A final report will be prepared that summarizes all of the existing and newly collected data on hydraulics, hydrology, sediment transport, bed and bank material distributions, and sedimentation patterns.
Gender-based violence and associated factors among female sex workers in Ethiopia. Evidence from The National Bio-behavioral Survey, 2020

Background Gender-based violence (GBV) is usually defined as unequal power relations between men and women, which poses a widespread public health problem. The study evaluated the prevalence and factors associated with GBV among female sex workers (FSWs) in Ethiopia. Method We used cross-sectional bio-behavioral data collected using respondent-driven sampling (RDS) in 2020 from 16 towns in Ethiopia. Descriptive statistics was analyzed to summarize the study population characteristics and prevalence of GBV, and a multilevel logistic regression model was applied to identify associated factors for GBV. A p-value of ≤0.05 was used as a threshold for statistical significance. Result Of 6,085 participants, 28.1% had experienced GBV during the last 12 months, among which 12.7% and 22.3% experienced physical and sexual violence, respectively. FSWs aged 15–24, and 25–34 than those 35 years or more, had a non-paying than paying partners, had 31–60, 61–90, and over 91 than those had less than 30 paying partners, ever had anal sex than those not, condom failure than those not, mobile female sex workers when compared with those not mobile at different town; 3–5 and ≥ 6 years than those less than 3 years stayed in selling sex, street-based, and multiple places selling sex than those used other venues were significantly associated with GBV. Conclusion Gender-based violence is a substantial problem among FSWs in Ethiopia, with significant implications for program planning on prevention and response to mitigate the occurrence and impact of GBV among FSWs.
Chemical Constituents of Ximenia Americana

Two steroids (1 and 2), five pentacyclic triperpenoids (3–7) and a new furanosesquiterpene (8) were isolated from the stems of Ximenia americana, family Olacaceae. The structures of the compounds were established by spectral data; two-dimensional NMR spectroscopy has been used to assign all 1H and 13C chemical shifts of 8. Compound 8 did not inhibit the growth of HL-60 (human leukemia), HTC-8 (human colon), and MDA-MB-435 (human breast cancer) cell lines.
SEBARAN TEMPORAL FAKTOR KONDISI KEPITING BAKAU (Scylla serrata) DI PERAIRAN PANTAI MAYANGAN,KABUPATEN SUBANG, JAWA BARAT TEMPORAL DISTRIBUTION OF CONDITION FACTOR OF MUDDY CRAB (Scylla serrata) IN MAYANGAN COASTAL WATERS, SUBANG REGENCY, WEST JAVA

Abstrak Scylla serrata merupakan salah satu jenis kepiting bakau yang dominan tertangkap di perairan Pantai Mayangan, Subang. Penelitian ini bertujuan untuk mengetahui sebaran temporal kondisi kepiting bakau (S. serrata) di perairan Pantai Mayangan, Subang ditinjau dari hubungan lebar karapas-berat dan faktor kondisinya. Data lebar karapas dan berat kepiting bakau dikumpulkan melalui enumerator sejakJanuari hingga November 2009 dan survei lapang dilakukan pada bulan April, Juni, Agustus dan November 2009 untuk validasi data. Hasil menunjukkan nilai b antara kepiting jantan (2,219 – 2,835) dan betina (1,2642,352) berbeda nyata (P<0,05). Keduanya memiliki pola pertumbuhan allometrik negatif dengan nilai b kepiting jantan cenderung lebih besar dibandingkan betina. Kisaran nilai K dan Kn kepiting jantan lebih lebar dibandingkan betina sehingga kepiting jantan cenderung lebih gemuk. Sebaran temporal faktor kondisi kepiting bakau diduga terkait dengan siklus reproduksinya. Nilai faktor kondisi meningkat sejak bulan Juni hingga puncaknya pada bulanOktober yang diduga pada saat tersebut merupakan puncak musim pemijahan kepiting bakau di perairan Pantai Mayangan. Kata kunci: faktor kondisi, pantai mayangan, Scylla serrata, sebaran temporal
Chishao (Paeoniae Radix Rubra) alleviates intra-hepatic cholestasis by modulating NTCP in rats

Background: Cholestasis is a common pathological manifestation dominated by accumulation of potentially toxic biliary compounds. Na+-taurocholate cotransporting polypeptide (NTCP) plays a critical role in protection from cholestasis and can be targeted therapeutically. Chishao (Paeoniae Radix Rubra) is a clinically efficacious agent for treating cholestasis, but the underlying mechanism has not been fully clarified. Objective: To evaluate the effects of Chishao on the expression of NTCP in rats with alpha-naphthylisothiocyanate (ANIT)-induced cholestasis. Methods: Chishao extracts were obtained by water decoction. Cholestasis model induced by ANIT in rats were established. Thirty rats were divided into five groups: control group (C), ANIT model group (M), 10 g/kg Chishao group (LD), 20 g/kg Chishao group (MD) and 40 g/kg Chishao group (HD). The levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), direct bilirubin (DB), alkaline phosphatase (ALP) and total bile acid (TBA) were detected. The mRNA and protein expression of NTCP, multidrug resistance associated protein 2 (MRP2) and bile salt export pump (BSEP) were detected by reverse transcription qPCR and Western blotting respectively. To assess the effects of Chishao on NTCP, MRP2 and BSEP localized at the membrane of hepatocytes, an in vitro experiment involving primary hepatocytes was conducted via the utilization of laser scanning confocal microscopy. Results: The extracts of Chishao significantly improved serum ALT, AST, ALP, TB, DB and TBA (p < 0.05), especially ALP in the HD group (p < 0.01). The histological pathological findings were also reversed in LD, MD and HD groups. The mRNA level of MRP2 was significantly downregulated after treatment with ANIT, whereas it was reversed in MD and HD groups (p < 0.05). The mRNA expression of NTCP was significantly downregulated after ANIT treatment, but dramatically upregulated in the HD group. The expressions of BSEP and MRP2 were similar, but that of NTCP decreased after ANIT treatment, which was reversed significantly by Chishao extracts in a dose-dependent manner. The expression of NTCP in hepatocytes from rats increased dose-dependently after Chishao treatment in vitro. Conclusion: Chishao extracts can improve the serum and histological performances of intra-hepatic cholestasis caused by ANIT, probably by working on transport proteins in liver cell membranes.
Succession in sub-boreal forests of West-Central British Columbia

Structural and compositional changes were ana- lysed over the course of 400+ yr of post-fire succession in the sub-boreal forests of west-central British Columbia. Using a chronosequence of 57 stands ranging from 11 to 438 yr in age, we examined changes in forest structure and composition with complementary PCA and DCA ordination techniques. To determine stand ages and timing of tree recruitment, approxi- mately 1800 trees were aged. Most early successional forests were dominated by Pinus contorta, which established rapidly following fire. Abies lasiocarpa and Picea glauca ∞ engel- mannii were also able to establish quickly, but continued to establish throughout the sere. Few Pinus contorta survived beyond 200 yr, resulting in major changes in forest structure. In some stands P. contorta never established, which led to considerable variation among stands less than 200 yr old. The oldest forests converged on dominance by Abies lasiocarpa. Vascular plant diversity decreased during succession whereas canopy structure became more complex as gap dynamics developed. Although these sub-boreal forests contain few tree species, successional changes were pronounced, with struc- ture changing more than composition across the chrono- sequence.
Tsunami Fragility — A New Measure to Identify Tsunami Damage —

Tsunami fragility (fragility curve, or fragility function) is a new measure, we propose, for estimating structural damage and fatalities due to tsunami attack, by integrating satellite remote sensing, field survey, numerical modeling, and historical data analysis with geographic information system (GIS). Tsunami fragility is expressed as the structural damage probability or fatality ratio related to hydrodynamic features of tsunami inundation flow, such as inundation depth, current velocity and hydrodynamic force. It expands the capability of estimating potential tsunami damage in a quantitative manner.
Image-Collection Summarization Using Scene-Graph Generation With External Knowledge

Summarization tasks aim to summarize multiple pieces of information into a short description or representative information. A text summarization task summarizes textual information into a short description, whereas an image collection summarization task summarizes an image collection into images or textual representation in which the challenge is to understand the relationship between images. In recent years, scene-graph generation has shown the advantage of describing the visual contexts of a single-image, and incorporating external knowledge into the scene-graph generation model has also given effective directions for unseen single-image scene-graph generation. While external knowledge has been implemented in related work, it is still challenging to use this information efficiently for relationship estimation during the summarization. Following this trend, in this paper, we propose a novel scene-graph-based image-collection summarization model that aims to generate a summarized scene-graph of an image collection. The key idea of the proposed method is to enhance the relation predictor toward relationships between images in an image collection incorporating knowledge graphs as external knowledge for training a model. With this approach, we build an end-to-end framework that can generate a summarized scene graph of an image collection. To evaluate the proposed method, we also build an extended annotated MS-COCO dataset for this task and introduce an evaluation process that focuses on estimating the similarity between a summarized scene graph and ground-truth scene graphs. Traditional evaluation focuses on calculating precision and recall scores, which involve true positive predictions without balancing precision and recall. Meanwhile, the proposed evaluation process focuses on calculating the F-score of the similarity between a summarized scene graph and ground-truth scene graphs, which aims to balance both false positives and false negatives. Experimental results show that using external knowledge to enhance the relation predictor achieves better results than existing methods.
The Late Paleozoic tectonic relationship between the Tian Shan orogenic belt and Junggar basin: Constraints from zircon SHRIMP U-Pb dating and geochemistry characteristics of volcanic rocks in Arbasay Formation

准噶尔盆地南缘沿巴音沟蛇绿岩带北侧发育一套晚古生代(原下二叠统)阿尔巴萨依组中基性、酸性火山岩夹火山碎屑岩。 采用锆石SHRIMPU-Pb定年方法,对其中流纹岩进行定年,得到年龄为307. 2±1.3Ma(MSWD=1.2),表明原定为早二叠世的阿尔巴萨依组火山岩的确切喷发时间为晚石炭世。 地球化学分析表明,阿尔巴萨依组火山岩为钙碱性和高钾钙碱性系列,富集轻稀土(LREE),轻重稀土有一定程度的分馏,富集大离子亲石元素(LILE),亏损Nb、Ta等高场强元素,流纹岩有Ba、Sr、P、Eu、Ti的异常。 阿尔巴萨依组火山岩的eNd(t)值在+4.21～+7. 79之间,显示源区富集特征。 晚石炭世阿尔巴萨依组火山岩、火山碎屑岩与后碰撞A型花岗岩在岩石学、地球化学特征方面相似,表明两者应有相似的构造背景,都为后碰撞伸展环境。 阿尔巴萨依组还发育一套火山沉积地层,表明准噶尔南缘沉积作用在晚石炭世已经开始,开始沉积盆地的类型应为伸展断陷盆地。
Hyperspecral Unmixing Based on Multilinear Mixing Model Using Convolutional Autoencoders

Unsupervised spectral unmixing (SU) consists of representing each observed pixel as a combination of several pure materials known as endmembers, along with their corresponding abundance fractions. Beyond the linear assumption, various nonlinear unmixing models have been proposed, with the associated optimization problems solved either by traditional optimization algorithms or deep learning techniques. Current deep-learning-based nonlinear unmixing mainly focuses on additive, bilinear-based formulations. The multilinear mixing model (MLM) offers a unique perspective by interpreting the reflection process by discrete Markov chains, allowing it to account for the interactions between endmembers up to infinite order. However, explicitly simulating the physics of MLM using neural networks has remained a challenging problem. In this article, we propose a novel autoencoder (AE)-based network for unsupervised unmixing based on MLM. Leveraging an elaborate network design, this approach explicitly models the relationships among all model parameters: endmembers, abundances, and transition probability. The network operates in two modes: MLM-1DAE, which considers only pixelwise spectral information, and MLM-3DAE, which explores spectral–spatial correlations within input patches. Experiments on both the synthetic and real datasets validate the effectiveness of the proposed method, demonstrating competitive performance compared with classic MLM-based solutions. The code is available at https://github.com/ting-Fang09/Hyperspectral-unmixing-MLM-AE.
Influence of irrigation regimes at different growth stages on development and yield in Maize (Zea mays, L.)

The maize (Zea mays, L.) was grown on a clay soil at Irrigation Development Area of Alwezaria, Kafrelshiekh, Egypt, during 2012 and 2013 seasons, to study the effect of irrigation regimes during different growth stages on growth, grain yield and water relations. Irrigation was applied at 50% (high level, H) and 65% (low level, L) depletion of available soil moisture (DAM) during different growth stages [vegetative stage (S1) from the third leaf (V3) to onset tasseling (VT) stages, reproductive stage I (S2) from VT to mid-milk (R3) stages, reproductive stage II (S3) from mid R3 to physiological maturity (R6)]. IHHH treatment (Irrigated at 50% DAM during three growth stages) or IHHL (Irrigated with 65% DAM at S3 stage only and 50% DAM was used during S1 and S2 growth stages), ILHH (Irrigated with 65% DAM at S1 growth stage only and 50% DAM was observed during S2 and S3 growth stages) and ILHL (Irrigated with 50% DAM at S2 growth stage only and 65% DAM was observed during S1 and S3 growth stages) resulted in significant increase in leaf area index (LAI) and dry weight/plant at 99 days after sowing (DAS), crop growth rate (CGR) at the period of 81-99 DAS, ear length, ear diameter, kernels number/ear, grain weight/ear, 100-grain weight and grain yield compared with ILLL (Irrigated with 65% DAM during three growth stages ) in the two seasons. There were no significant differences in grain yield among the irrigation treatments IHHH, IHHL, ILHH and ILHL in the mentioned traits in both seasons. Abundance soil moisture in root zone during S2 stage (containing tasseling, silking, blister and mid-milk stages) is necessary to achieve high grain yield equal to that during entire season. IHHH treatment recorded the highest values of applied water (7286 and 7321m3/ha), while ILLL recorded the lowest values 6171 and 6198 m3/ha in the two seasons. Although, the treatments received irrigation at 50% DAM during S2 stage (IHHL, ILHH and ILHL treatments) were equivalent to those received irrigation at 50% DAM during entire seasons (IHHH treatment), they were lower in amount of applied irrigation water and water consumptive use. They saved at least 11.3, 16.0 and 19.9% applied water parallel with the yield decrease at the most 3.1, 3.2 and 5.3% than IHHH treatment, respectively. Also, they increased the productivity of applied water (WPwater applied) and water consumptive use (WP WCU) (kg grain/m3 water) compared with IHHH in both seasons. At North Delta, Penman Monteith equation can be used in determining the actual consumptive use and the average of crop Coefficient (Kc) for the two seasons was found to be 0.43, 0.54, 0.64, 0.58 and 0.51 during emergence, vegetative, tasseling to milk, milk to dent and dent to maturity stages, respectively. Therefore, when irrigation water becomes a limited factor for agriculture, we can apply ILHL treatment which resulted in high grain yield and water productivity equal to IHHH with less amount of applied irrigation water and consumptive use in Kafrelshiekh Governorate.