Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparisons of Long-Term Survival and Safety of Haploidentical Hematopoietic Stem Cell Transplantation After CAR-T Cell Therapy or Chemotherapy in Pediatric Patients With First Relapse of B-Cell Acute Lymphoblastic Leukemia Based on MRD-Guided Treatment

Measurable residual disease (MRD) positivity before haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is an independent prognostic factor in determining outcomes in patients with B-cell acute lymphoblastic leukemia (ALL). In this study, we conducted a parallel comparison of the efficacy and safety in patients with suboptimal MRD response after reinduction who underwent haplo-HSCT after chimeric antigen receptor T-cell (CAR-T) therapy or chemotherapy. Forty B-cell ALL patients who relapsed after first-line chemotherapy and with an MRD ≥0.1% after reinduction were analyzed. The median pre-HSCT MRD in the CAR-T group (n = 26) was significantly lower than that in the chemotherapy group (n = 14) (0.009% vs. 0.3%, p = 0.006). The CAR-T group exhibited a trend toward improved 3-year leukemia-free survival and a significantly improved 3-year overall survival compared to the chemotherapy group [71.8% (95% confidence interval (CI): 53.9–89.6) vs. 44.4% (95% CI: 15.4–73.4), p = 0.19 and 84.6% (95% CI: 70.6–98.5) vs. 40.0% (95% CI: 12.7–67.2), p = 0.008; respectively]. Furthermore, no increased risk of graft-versus-host disease, treatment-related mortality, or infection was observed in the CAR-T group. Our study suggests that CAR-T therapy effectively eliminates pre-HSCT MRD, resulting in better survival in the context of haplo-HSCT.
Exploring links between ownership, governance and condition of stormwater quality improvement devices

Local government uses the development approval process to place responsibility for stormwater treatment with private landholders through the installation of stormwater quality improvement devices on their land. This source control strategy can complement publicly owned and managed centralized solutions to improve urban water quality outcomes. The maintenance of decentralized solutions for waterway health is compromised by the motivation of individuals whose professed value of cleaner waterways is not evident in their individual lot-based actions. This exploratory research makes four policy and governance observations: waterway policy should consider property scale and ownership type when allocating responsibility for stormwater treatment; devices need to be integrated within the landscape and be publicly visible; education and regulation are advised in order to better support devices placed in private ownership; and policy will be more likely to achieve cleaner waterways if it aligns the motivations of waterway scientists, maintenance actors and property owners.
Sinonasal mucosal melanomas: defining profiles for better survival outcomes.

BACKGROUND Sinonasal mucosal melanoma is an aggressive malignancy with a 5-year survival rate ranging from 20% to 39%. Despite the evolving surgical and radiotherapy techniques, and introduction of immune-checkpoint inhibitor therapy, overall survival rates remain poor. METHODOLOGY A retrospective cohort study was conducted at the Hospital Clinic de Barcelona and the Hospital de la Santa Creu i Sant Pau between 1984 and 2020; primary outcome measures were 3 and 5-year melanoma-specific survival (MSS). Kaplan-Meier survival analysis and Cox proportional hazards model were performed to identify predictors of survival. RESULTS Fifty patients were included, the mean age was 70.4, MSS at 3 and 5 years was 51.2%, and 29.5%, respectively. The median follow-up was 39.6 months during which 46% presented locoregional recurrence and 36%, metastasis. The univariate and multivariate analyses found as survival predictors the N category, the treatment received, the surgical margins and the mitotic index. CONCLUSIONS We found an overall 5-year MSS of 29.5%. Those patients with intention-to-cure (stages III and IVa) treated by surgery that were N0 at diagnosis, with < 10 mitoses per HPF showed a 5-year MSS rate of 74.1%. More studies will be needed to adequately define the patients' profiles that will benefit from a better survival outcome.
Routine Blood Profiles of Global Ischemic Rats Based on Ischemia Durations

Stroke is the third cause of death and the first cause of disability in the world. It is around 80% of stroke patients in the world are ischemic stroke. According to the development of stroke models in animals, BCCAO is one technique that can induce global cerebral ischemia. An ischemia is known to influence activities of inflammatory cells which can be measured through peripheral blood. This study aims to determine effects of ischemia duration on routine blood profiles of rats (Rattus norvegicus) after bilateral common carotid artery occlusion (BCCAO). This study was a quasi-experimental study. Its subjects were adult Wistar rats (Rattus norvegicus). The rats were grouped into four treatment groups, and each group consisted of 6 rats. Group A was a group of sham-operated rats, group B was a group of rats with ischemia duration for 5 minutes, group C was a group of rats with ischemia duration for 10 minutes, and group D was a group of rats with ischemia duration for 20 minutes. Its obtained data were analysed by one-way ANOVA test and Post Hoc Tamhane's test. The ischemia duration significantly influenced the neutrophil and lymphocyte count after ischemia, with p < 0.05. The ischemia duration could affect the routine blood profiles of the rats after BCCAO, especially the neutrophil and lymphocyte count.
Synthesis and characterization of MgB2 superconductors with carbon nanotubes (CNTs) and tin (Sn) addition

MgB2/CNT is a promising candidate for superconducting wire application due to its excellent mechanical properties and carbon nanotube’s low density. However, strong interfacial adhesion between the CNT reinforcement and the MgB2 matrix is difficult to manage. Therefore, this study examines the synthesis and characterization of magnesium diboride (MgB2) superconductors with carbon nanotubes (CNTs) and tin (Sn) addition. Determining the proper method and combination of CNT & Sn affects MgB2 superconductors is crucial. Raw materials of magnesium (Mg), boron (B), Sn, and multi-walled carbon nanotubes (MWCNTs) were used for a solid-state reaction process to determine the proper synthesis method and the effect of CNT on superconductors’ critical temperature. Each sample was obtained by weighing the raw material first, followed by hand grinding with agate mortars for 3 hours. The pelletization was then conducted by using a compact pressing machine with a pressure of 350 MPa. The compacted samples were then sintered at 800 °C for 2 hours either through the vacuum or PIST process. Finally, all were characterized, and MgB2 was discovered to be the dominant phase with minor impurity phases such as MgO, Mg, Mg2Sn, C, and Sn. Based on SEM morphological analysis, the grain boundaries of sample A1 were more precise than B2. In both, the grain size also varies, and the distribution of elements is uneven. Subsequently, Cryogenic Magnet Characterization indicated that at 40 K, almost all samples possess superconducting characteristics. For future studies, the potential impact of MgB2 on critical current density (Jc) and magnetic density (Hc) in several commercial applications such as Magnetic Resonance Imaging (MRI), magnetic levitation, and transformers needs to be investigated
“This pandemic has changed our daily living”: Young adults’ leisure experiences during the COVID-19 pandemic in South Africa

ABSTRACT The COVID-19 pandemic is a global human ecosystem disruption affecting almost every facet of daily living. South Africa adopted a risk-adjusted approach comprising five-levels to curb the spread of COVID-19. Early in 2020, the country experienced level 5 and 4 restrictions, indicating high COVID-19 spread with low to moderate health system readiness. South Africans were largely confined to their homes. This study explored young adults’ experiences of leisure engagement during the confinement, adaptations made, and the influence on health and well-being. Thirteen occupational therapy student researchers conducted individual qualitative, exploratory-descriptive studies on young adults’ leisure experiences during the level 5 and 4 confinements. The authors used a qualitative meta-analytic approach to review the student researchers’ primary studies and synthesize findings for this paper. The sample comprised 65 participants aged 18 to 32 years (mean age 22.2 years), the majority being either students or employed. Participants were interviewed online or submitted written responses to open-ended questions focusing on their leisure engagement during the confinement. Relevant data were extracted from the primary studies and analyzed thematically. Four themes emerged: 1) disruption, 2) time, 3) adaptations to change, and 4) leisure benefits. Although participants experienced the confinement as disruptive, and restricting their leisure and social engagement, they adapted and developed new leisure occupations, which had a positive influence on their health and well-being. In conclusion, the young adults dealt with the occupational injustices of confinement by adapting their leisure engagement, thus displaying occupational resilience, which positively influenced health and well-being.
An Investigation of Ionospheric TEC Prediction Maps Over China Using Bidirectional Long Short‐Term Memory Method

The ionospheric total electron content (TEC) is an important ionospheric parameter, and it is widely utilized in research such as space weather prediction and precise positioning. However, it is still challenging to develop an ionospheric TEC prediction model with high accuracy. In this study, a new ionospheric TEC model over China was developed using the bidirectional long short‐term memory (bi‐LSTM) method and observations from 257 ground‐based global navigation satellite system (GNSS) stations in the Crustal Movement Observation Network of China from January 2018 to December 2021. The root mean square errors of the bi‐LSTM‐based model’s 1 and 2 hr ahead predictions on the test data set (from June 2021 to December 2021) are 1.12 and 1.68 TECU, respectively, which are 75/50/32% and 72/48/22% smaller than those of the IRI‐2016, artificial neural network and LSTM‐based models, correspondingly. The bi‐LSTM‐based model shows the best performance, which is most likely due to the fact that the sequence information in both forward and backward directions is taken into consideration in the new model. In addition, the diurnal variation, seasonal variation of the ionospheric TEC, and variations under geomagnetic storm conditions are successfully captured by the bi‐LSTM‐based model. Moreover, the TEC maps resulting from the bi‐LSTM model agree well with those obtained from the final ionospheric product from the Chinese Academy of Sciences. Hence, the new model can be a good choice for the investigation of the spatiotemporal variation trend in the ionosphere and GNSS navigation.
Riverbed Temperature and 4D ERT Monitoring Reveals Heterogenous Horizontal and Vertical Groundwater-Surface Water Exchange Flows Under Dynamic Stage Conditions

Groundwater surface water exchange plays a critical role in physical, biological, and geochemical function of coastal and riverine systems. Observing exchange flow behavior in heterogeneous systems is a primary challenge, particularly when flows are governed by dynamic river stage or tidal variations. In this paper we demonstrate a novel application of time-lapse 3D electrical resistivity tomography and temperature monitoring where an array of thermistors installed beneath a riverbed double as resistivity electrodes. We use the array to monitor stage driven exchange flows over a 6-day period in a dynamic, stage-driven high order stream. We present a method for addressing the otherwise confounding effects of the moving river-surface boundary on the raw resistivity data, thereby enabling successful tomographic imaging. Temperature time-series at each thermistor location and time-lapse 3D images of changes in bulk electrical conductivity together provide a detailed description of exchange dynamics over a 10-meter by 45-meter section of the riverbed, to a depth of approximately 5 m. Results reveal highly variable flux behavior throughout the monitoring domain including both horizontal and vertical exchange flows.
Burnout and work satisfaction are differentially associated in gastroenterologists in Germany.

BACKGROUND Burnout in the field of gastroenterology is an under-researched phenomenon. So far, only a few studies have dealt with this topic. There are large geographical variations in burnout rates with 16-20% of gastroenterologists in Mexico and Germany being at risk or having burnout, 30-40% in the United Kingdom, and 50-55% in South Korea, Canada, and the USA. The investigation of differential associations of burnout with important factors in gastroenterologists leading to tailored therapy recommendations is lacking. Therefore, we investigated the associations between work satisfaction and burnout in this specialization. METHODS We distributed an electronic survey to gastroenterologists organized mainly in the Federal Organization of Gastroenterology in Germany (the BVGD - Bundesverband Gastroenterologie Deutschland). The Maslach Burnout Inventory (MBI) and the Work Satisfaction Questionnaire (WSQ) were examined regarding their postulated internal structure in our sample of gastroenterologists. Canonical correlations were performed to examine the association between work satisfaction and burnout in endoscopy physicians. RESULTS An acceptable model fit was shown for both the MBI and the Work Satisfaction Questionnaire. The canonical correlation analysis resulted in two statistically significant canonical functions with correlations of . 62 (p<.001) and . 27 (p<.001). The full model across all functions was significant (χ 2 (18) = 386.26, p<. 001). Burden, personal rewards, and global item regarding the job situation were good predictors for less exhaustion, while patient care and professional relations were good predictors for personal accomplishment. This supports the recognition of burnout as being a multidimensional construct which has to be thoroughly diagnosed. CONCLUSIONS Specific interventions should be designed to improve symptoms of burnout in endoscopy physicians according to their individual complaints as burnout is a multidimensional construct. Differential interventions should be offered on the basis of our study results in order to alleviate the issue of work satisfaction and burnout in endoscopy physicians.
The dynamics of Paiku Co lake area in response to climate change

With the drastic change in global climate, the wide distribution of natural lakes over the Qinghai-Tibet Plateau (TP) has attracted extensive attention due to their high climate sensitivity. In this paper, we investigated the dynamics of Paiku Co, the largest inland lake in the Qomolangma Natural Reserve, with the associated response to climate change in the past three decades. The methods used contain the water index method, the spatial and temporal fusion model, the statistical mono-window algorithm, and multi-variable linear regression. Lake area fluctuated greatly in 1990–2000, followed by a continuous shrinkage in 2000–2010, and stabled after that 2010–2020. We forecasted that Paiku Co would enter a slow expansion period. Conjoint analysis with climate factors showed that the area variation of Paiku Co was not significantly related to precipitation change, but negatively related to the change of air temperature and lake temperature. We found that the lake change was not dominated by a single factor but showed different climate sensitivity in each period. Especially, there was a common inflection point around 2013 that might herald the occurrence of a new trend of climate change. This article provides new ideas and solutions for the research of lakes in the Qinghai-Tibet Plateau and offers a reference for water resource management.
The effect of learning management system on ICU nurses' sustained learning about safe blood transfusion: A quasi‐experimental study

Transfusion of blood products is an important part of the health care system. Since one of the significant challenges in nursing education is using an effective method that provides depth and stability of learning, this study aimed to assess using a learning management system (LMS) for intensive care unit (ICU) nurses' sustained learning about safe blood transfusion in southeast Iran.
Risk and Protective Factors Experienced by Fathers of Refugee Background during the Early Years of Parenting: A Qualitative Study

Fathers of refugee background with young children can experience significant mental health difficulties, with the potential for intergenerational impacts. This study aimed to explore how fathers of refugee background experience risk and protective factors for their own health and wellbeing during the early years of parenting. Semi-structured interviews and one semi-structured focus group were conducted with fathers of refugee background, with young children (0–5 years), who had settled in Australia. Transcribed interviews were analysed using thematic analysis, informed by the socioecological model of health. A total of 21 fathers participated in the study. Risk factors experienced included: prior experiences of trauma, reduced access to family support in Australia, adjustments in parenting roles, and the challenges of learning a new language and securing employment. Fathers drew on a number of sources of strength, including a sense of joy from fatherhood and support from partners, families, and communities. While most fathers regularly accompanied their partners and children to healthcare appointments, they were rarely asked by healthcare professionals about their own needs. Our findings support the idea that there is a need for greater assistance for fathers, particularly for navigating issues arising from the settlement process. Healthcare services working with families of refugee background must adopt a father-inclusive, trauma-informed approach that is responsive to fathers’ needs.
Retrospective Study from a Single Center to Identify Risk Factors Associated with Reinfection in Patients Undergoing 2-Stage Revision Surgery for Periprosthetic Joint Infection

Background This study identified risk factors associated with reinfection and created a scoring system designed for patients with periprosthetic joint infection (PJI) who have undergone prosthetic resection and spacer implantation. Material/Methods Patients who underwent 2-stage revision for PJI from January 2010 to December 2017 were retrospectively analyzed in this study. Patients were divided into 2 groups: infection recurrence and infection cure. Demographic and clinical information, laboratory test results, and radiological images that were potentially associated with infection were obtained and analyzed. Results Seven independent risk (protective) factors for infection recurrence in patients with PJI who underwent 2-stage hip revision surgery were identified: C-reactive protein level, type of bacterial infection, age, immunosuppression, albumin/globulin ratio, glucose level, and magnetic resonance imaging findings. Finally, a weighted scoring system of 100-mark system was established and the area under the curve was 0.965 (95% confidential interval=0.947–0.983). The predictive scores for low risk (≤30%), moderate risk (31–69%), and high risk (≥70%) of infection recurrence were ≤45, 46–77, and ≥78, respectively. Conclusions For patients with PJI who had already undergone joint resection and spacer implantation, this newly established scoring system might help determine the accurate risk of infection recurrence after a definitive new prosthesis implantation. Patients with scores greater than 78 points would be considered very likely to have an infection recurrence. Therefore, the second-stage revision surgery should be changed to an additional anti-infection treatment or a debridement surgery instead of a definitive prosthesis implantation surgery.
Effects of Bionic Pectoral Fin Rays’ Spanwise Flexibility on Forwarding Propulsion Performance

Oscillating pectoral fins’ spanwise flexibility is a key factor influencing the forwarding propulsion performance of bionic cownose rays, including thrust and heave-pitch stability. This study explores the effects of the bionic pectoral fin ray’s spanwise flexibility on its propulsion performance via experiments. Inspired by the cownose ray, a pair of bionic pectoral fins with fin rays and fabric skin was designed, and two motors drive the controllable flapping motion. The bionic pectoral fins’ flexibility can be quantified by using fin rays’ bending stiffness. The experiments were carried out in a water tank to measure the thrust, the lift force, and the pitch moment of the bionic cownose ray. The fin rays are divided into plastic sheets of five thicknesses and three fin rays with more obvious stiffness variations. The movement parameters included the following: the flapping frequency of 0.3–0.7 Hz, the flapping amplitude of 20–40°, and the phase difference of 20–40°. The experimental results show that the stiffness of the bionic pectoral fin rays plays an important role in the thrust, lift force, and pitch moment. The fin rays with high stiffness root segment and low stiffness tip segment have lower lift and pitch moment while maintaining a high thrust. This shows that the pectoral fins’ flexible characteristics of the cownose ray are of great significance to the design of the bionic prototype.
An Exploratory Study of Consumers’ Perceptions of Product Types and Factors Affecting Purchase Intentions in the Subscription Economy: 99 Subscription Business Cases

This study examined changes in consumer perceptions of product types and purchase intentions when a subscription model is introduced for products normally sold on a one-time basis. It then proposed product types likely to affect consumers’ purchasing intentions in the subscription economy and product categories best suited for the subscription economy. To this end, an experimental study was conducted with experts and general consumers using 99 subscription business cases. It was found that a regular delivery of products on a subscription basis gradually changes consumer perceptions of the products from utilitarian to hedonic and from search to experience ones. It was also found that consumption motivation is an important predictor of consumer purchase intentions in the subscription economy. In addition, experience-utilitarian and search-utilitarian products were associated with the highest purchase intentions among experts and general consumers, respectively. This suggests that a company’s strategy should be adjusted in line with consumers’ understanding of the subscription model. Therefore, suppliers need to understand the full implications of the new model, such as changed consumer perceptions and purchasing intentions, and strive to design a subscription model that is suitable for the target segments and product selections.