Miracle-dz/UniFAR-FTUs huggingface dataset:
Pengembangan Infrastruktur Konektifitas Sebagai Daya Ungkit Ekonomi Dan Pemangkas Kemiskinan Jawa Timur

Kesinambungan antar wilayah menjadi instrumen fundamental dalam mendongkrak pergerakan aktifitas ekonomi. Penelitian bertujuan menguji kontribusi pembangunan infrastruktur terhadap produktifitas ekonomi serta implikasinya terhadap kemiskinan di Jawa Timur. Penelitian menggunakan pendekatan kuantitatif eksplanatori berbasis data panel tahun 2012-2016 dan menggunakan teknik two stage least square dengan melibatkan variabel belanja infrastruktur, kapasitas listrik, akses air minum, akomodasi, IKK, PDRB, serta kemiskinan. Penentuan sampel dengan pendekatan non probability sampling yaitu 195 observasi. Hasil penelitian menunjukkan penyediaan infrastruktur berpengaruh positif terhadap pertumbuhan ekonomi wilayah dan menurunkan kemiskinan. Belanja infrastruktur, kapasitas listrik serta bangunan akomodasi berpengaruh signifikan positif terhadap ekonomi regional. Peningkatan 1% kapasitas listrik diproyeksikan mendorong 0.045% pertumbuhan ekonomi. Akses air minum berpengaruh tidak signifikan terhadap pertumbuhan ekonomi dengan p-value 0,904. Penyediaan infrastruktur menciptakan konektifitas dan perdagangan. Peningkatan aktifitas ekonomi berimplikasi terhadap penurunan kemiskinan. Kenaikan 1% pertumbuhan ekonomi diestimasikan menurunkan kemiskinan sebesar 1,1%.
Canada’s mental health legislation

In Canada the ten provinces and three territories are responsible for their own health laws and services. The 13 mental health acts have core similarities, but there are clinically significant differences. In most Canadian jurisdictions legislation is based on common law; in Quebec, it is based on a civil code. Canadian jurisdictions favour voluntary admission and sometimes make this explicit in their mental health acts. For involuntary admission or compulsory in-patient or community treatment to be valid, three elements must be applied correctly: the process, the criteria and the rights procedures. These are reviewed in this paper.
ENGLISH L2 DEFINITE ARTICLE INSTRUCTION AT THE SERBIAN L1 TERTIARY LEVEL

The study has two main goals: to assess in part the effects of current definite article instruction at the tertiary level in the Serbian L1/English L2 environment, and to analyze whether the use of the definite article in English could be represented by figure/ground alignment in the instruction process. One of the questionnaires used (consisting of fill-in-the-blank tasks) was meant to rate the participants’ L2 definite article production in the contexts for its obligatory use. Another questionnaire consisted of illustrations of figure/ground alignment as cues for a translation task meant to assess whether the definite article would be used in situations where the referent of choice was presented as the figure. An analysis of the data indicated that the participants, who displayed various levels of knowledge of definite article use on the first questionnaire, scored identical (successful) results when establishing a link between the use of the definite article and figure/ground alignment. These results could prove useful for innovating the L2 instruction process in the Serbian L1/English L2 environment.
The sprightly little sphaerodactyl: Systematics and biogeography of the Puerto Rican dwarf geckos Sphaerodactylus (Gekkota, Sphaerodactylidae).

Studies of the Caribbean herpetofauna (amphibians and reptiles) have made significant contributions to our knowledge of evolutionary patterns and processes. A prerequisite for these studies are accurate taxonomies and robust phylogenetic hypotheses. One notable Caribbean radiation lacking such data are dwarf geckos of the genus Sphaerodactylus. Systematics of the Puerto Rican Sphaerodactylus have been turbulent since the initial species descriptions and no molecular phylogenies exist that include complete or near-complete taxon sampling. Here, we combine a multi-locus molecular phylogeny with extensive morphological information to investigate the current diversity of Sphaerodactylus geckos from the Puerto Rican Bank, with a large number of species from Hispaniola as an outgroup. In particular, we focus our efforts on resolving the taxonomy of the Sphaerodactylus macrolepis Günther species complex. We find S. macrolepis sensu lato (currently two nominal species with nine subspecies) is made up of at least four diagnosable species within two clades: (1) the sister species Sphaerodactylus macrolepis sensu stricto from the Virgin Islands (including St. Croix) and Culebra, and S. parvus King from islands in the northern Lesser Antilles; and (2) all other Sphaerodactylus macrolepis subspecies from Puerto Rico, Vieques, and Culebra. We resurrect Sphaerodactylus grandisquamis Stejneger from synonymy to refer to all subspecies from Puerto Rico and elevate the subspecies Sphaerodactylus inigoi Thomas Schwartz for geckos from Vieques and western Culebra. The resulting phylogeny and revised taxonomy will be a useful tool for subsequent research into Sphaerodactylus conservation and evolution.
DETECTION OF NUCLEOPHOSMIN (NPM-1) AND FLT3-ITD MUTATIONS IN 30 IRAQI PEDIATRIC ACUTE MYELOID LEUKEMIA PATIENTS

Background Mutation within the FLT 3 and NPM 1 genes ranked within the most frequent recurrent known genetic markers in acute myeloid leukemia (AML) and show apparently opposite prognostic significance. Objective To detect the frequency of FLT3-ITD and NPM-1 mutations in Iraqi pediatric AML patients using conventional polymerized chain reaction (PCR), and to relate their prevalence with the clinical presentation and the response to induction therapy. Methods A prospective study of 30 children presented with AML and 16 children who were age and gender matched served as negative control for the mutation. AML cases were classified according to FAB classification. WBC count, platelet count and hematocrit were measured at diagnosis and after 30 days. Molecular analysis was done on peripheral blood or bone marrow aspirate samples by conventional PCR technology. Results FLT 3-ITD mutation was detected in 3/30 (10%) patients, whereas NPM1 mutation was detected in 4/30 (13.33%) patients. Both mutations were detected in older age patients and predominantly in male. No significant correlation between each mutation and various hematological parameters, however WBC count was significantly higher in FLT-ITD unmutated patients. FLT3-ITD mutation was detected in M3 and M3 variant whereas NPM-1 mutation was detected in M2 and M3v. The three patients having FLT-3-ITD mutation (100%) did not achieved complete hematological remission, whereas 3/24 (12.5%) patients without the mutation did not achieve remission. On the other hand 2 out of 4 (50%) patients with NPM1 mutation had not achieved complete hematological remission and 4/22 (18.18%) patients without mutation did not achieve remission. Finally regarding the interrelation between the two mutations, the two children who had NPM1 mutation and no FLT3-ITD mutation had achieved complete remission on induction therapy whereas the three children who had FLT3-ITD mutation with or without NPM1 mutation did not achieved complete remission. Conclusion Prevalence of FLT3-ITD and NPM-1 mutations in Iraqi pediatric AML patients is comparable to that recorded worldwide and both mutations were observed in older age children and mainly in male. FLT3ITD mutation unlike NPM-1 mutation associate with poor response to induction therapy and the adverse effect of FLT3-ITD mutation overcome the favorable effect of NPM-1 mutation when they exist together.
The Lambert-Eaton Myasthenic Syndrome — an Overview

Abstract The Lambert Eaton myasthenic syndrome (LEMS) has a prevalence of around 5/100 0000 and is around 10–20 times rarer than myasthenia gravis (MG). Although LEMS does have a number of similarities to MG, there are important differences. The syndrome is characterized by a mostly proximally localised exercise induced muscle weakness that can lead to respiratory failure often accompanied by autonomous dysfunction. Disease symptoms are caused by autoantibodies directed against P/Q type voltage gated calcium channels (VGCC) that are expressed in the presynaptic motoric nerve terminals. The diagnosis of LEMS is based on the detection of the pathogenic anti-VGCC antibodies as well as the observation of an increment of at least 60% in the electrophysiological examination of an affected muscle. An increment is defined by an increase of the at rest reduced compound muscle action potential (CMAP) either after voluntary maximal innervation or after high frequent (≥20 Hz) stimulation. In almost one third LEMS is of paraneoplastic origin. Therefore an intensive tumor screening is necessary after diagnosis.There are some differences in the clinical presentation between paraneoplastic (pLEMS) and the exclusively autoimmune (aiLEMS) form of LEMS. With respect to this the DELTA-P-Score and the detection of SOX1-antibody are important. The most frequent tumor associated with LEMS is small cell lung carcinoma (SCLC). Therapy is based on the initial distinction between paraneoplastic and autoimmune ethiology. pLEMS necessitates therapy of underlying neoplasia. Usually, aiLEMS- as well as pLEMS patients respond well to 3,4 diaminopyridine (3,4 DAP) often augmented by pyridostigmine. Similar to treatment of myasthenia gravis long-term immunosuppressive treatment is usually required to control symptoms effectively. Myasthenic crisis in LEMS can be controlled by intensive care and immunoglobulins, plasmaphereses or immunoadsorption. Based on case reports more specific immunomodulatory treatment approaches such as the B-cell depleting therapeutic antibody rituximab should be considered in therapy refractory courses of LEMS. Long-term prognosis of autoimmune LEMS with respect to clinical stabilization with (pharmacological) remission is good, although in around 75% of patients significant reductions in quality of life remain. Prognosis of tumor-associated LEMS is largely determined by the tumor and its effective therapy. Curative treatment of the tumour as well as complete remission of pLEMS are possible.
STUDY OF SOCIO-DEMOGRAPHIC CHARACTERISTICS OF PATIENTS WITH CONGENITAL COAGULATION DISORDERS

Background: patients with genetic deficiencies of plasma coagulation factors exhibit life-long recurrent bleeding episodes into joints, muscles and closed space, either spontaneously or following an injury. Objective: The present study aimed to determine the socio-demographic characteristics of patients with congenital coagulation disorders. Methods: A cross-sectional study was conducted at the Centre of Congenital Coagulation Disorders in the Al-Mansour Pediatric Teaching Hospital in Baghdad for the period between 1 of March to 31 of August 2008. The study sample was comprised of 243 patients with different congenital coagulation disorders who attended the Centre during the study period. Data were collected through well structured questionnaire form introduced only by the researcher by interviewing with the patient or his/her relative or care giver. Results: showed that hemophilia and Von Willebrand Disease (VWD) constituted the majority (90.1%), of the studied sample The mean age of all patients was 14.31 ±10.42 years. About 77% of patients were from Baghdad governorate. Some families (15.6%) of the studied patients had three or more members with congenital coagulation disorders. For those patients aged ≥7 years, 41% of them had not attended or left school due to their disease. For those patients aged ≥18 years, 68.4% of them were unmarried, and 45.07% of them had no work due to their disease. Treatments were available to the majority (97.1%) of patients Conclusions: The features in this study were similar to other studies in Mediterranean region and Western countries, except that the mean age of patients in this study was lower than that in other studies, blood groups showed no significant effect on types of congenital coagulation disorders, the disease showed adverse effects on all levels of education of patients
Infection control in intensive care units

Infections acquired in the hospitals, especially in the intensive care unit (ICU) settings, ranging between 15% and 20%, may further lead to complications in >40% in critically ill patients. The order of incidence may vary in different settings, but the most usual causes are ventilator-associated pneumonia, intravascular catheter-associated bloodstream infection, catheter-associated urinary tract infection, posttraumatic intra-abdominal infection, and surgical site infection. These can be prevented by adequate and appropriate application of preventive strategies, which can be implemented strictly at the bedside. The basic norms for surveillance strategies, general preventive measures such as standard and isolation precautions and monitoring of antibiotic use should be followed without fail. Specific practical measures for ICU-related infections should be in place, and the monitoring of activities should be documented regularly as “bundle-care” in view of standardizing the practice, irrespective of place or person. Adequate attention, unfortunately, has not been paid for infection control measures in India for years. It is now mandatory that the essential practices are prioritized and integrated fully into regular hospital administrative procedure as a continuous process for improving quality health care.
Novel Pharmacological Action of Clozapine at D2 Dopamine Receptors

Clozapine is an antipsychotic drug (APD) with a uniquely efficacious therapeutic profile that is preeminent for treatment resistant schizophrenia. A common property of all clinically available APDs is that they bind D2-like dopamine receptors at therapeutic concentrations. However, unique molecular actions for clozapine that are different from all other APDs have not been established. Here we show that treatment with all APDs upregulates cell-surface expression of D2-dopamine receptors (D2R), relative to that produced by clozapine. Multiple experiments, including a pulse-chase assay for surface D2R indicated that the APD-mediated upregulation of D2R is due to enhanced insertion of D2R into the plasma membrane and not differences in receptor occupancy or protein synthesis. The potency of amisulpride, an APD with poor membrane permeability, for upregulating surface D2R was increased by coexpressing OCT1, an amisulpride transporter, suggesting an intracellular site of action for APDs. Competition experiments and experiments with a non-APD-binding D2R mutant indicated that APD upregulation of surface D2R is a consequence of direct receptor binding. Enhancement by APDs of surface D2R, relative to that produced by clozapine, was magnified in both a glycosylation-deficient and a misfolding D2R mutant. Moreover, every APD, except clozapine, enhanced the detergent solubility of intracellular D2R. These and other data suggest that APDs act intracellularly as chemical chaperones to stabilize a conformation of D2R with enhanced detergent solubility and transport to the cell surface. These results display a unique molecular event of clozapine at D2R, as it possesses the lowest efficacy with respect to these actions of APDs. Results displaying unique binding of clozapine to D2R harbor intriguing implications for APD discovery and development, and provokes novel speculative thought and questions on the nature of ligand-receptor interaction.
PENGARUH EARNINGS PER SHARE (EPS), RETURN ON EQUITY (ROE), RETURN ON ASSETS (ROA), DAN NET PROFIT MARGIN (NPM) TERHADAP HARGA SAHAM (Studi pada Perusahaan Property dan Real Estate yang terdaftar di Bursa Efek Indonesia tahun 2014-2018)

Investment in the capital market is a form of investment that is profitable but also high risk, so investors in investing need accurate information so that they are not trapped in adverse conditions. This information is used to find out variables that can affect stock price fluctuations. This study aims to determine the effect of EPS, ROE, ROA, and NPM on stock prices. This research was conducted by explanatory research method with a quantitative approach, where the data used in the form of secondary data. The population in this study were Property and Real Estate companies listed on the Indonesia Stock Exchange in 2014-2018, which numbered 50 companies. The number of samples used was 21 companies with Purposive Sampling techniques. The method of data analysis uses multiple linear regression analysis which is processed with SPSS. The results of this study indicate that the effect of EPS, ROE, ROA and NPM tested on stock prices shows that the value of tcount is (9,401> 1,984), (2,645> 1,984), (2,163> 1,984) and (0.009 <1,984) with the probability level significance with a significance level of 0.05. It can be concluded that partially the EPS ROE variable and ROA have an influence on the stock prices of Property Companies and real estate listed on the Indonesia Stock Exchange in 2014-2018. While the NPM variable has no influence on the stock prices of Property Companies and real estate listed on the Indonesia Stock Exchange in 2014-2018. Based on the F Test above, it shows that the Fcount is 31.581 while Ftable is 2.46 with a significance level α = 0.05. From these data indicate that Fcount> Ftable (31.581> 2.46) and probability of significance 0.000 <0.05. Then H5 is accepted and H0 is rejected, so it can be concluded that EPS (X1), ROE (X2), ROA (X3), and NPM (X4) variables simultaneously or jointly have a significant effect on the share price of Property Companies and real estate.
Prevalence and determinants of corneal blindness in a Semi-Urban population of southwest Nigeria

Purpose: To determine the prevalence and determinants of corneal blindness in a semi-urban population of Southwest Nigeria. Materials and Methods: This population-based, cross-sectional study was conducted over a period of two months from 3rd March to 30th April 2014. A multi-stage sampling method with probability proportional to size procedure was used to select 1002 participants. The study involved obtaining information from the participants on demographic data and ocular history suggestive of the causes of corneal blindness using interviewer-administered questionnaires. Ocular examinations of the anterior and posterior segments of the participants were performed using pen touch, magnifying loupe, slit lamp and direct ophthalmoscope. The data collected were analyzed using the Statistical Package for Social Sciences software version 22. Summary statistics was presented using frequency tables, charts, means and rates. The level of statistical significance was set at 5%. Results: There were 1002 participants (410 males and 592 females). Their age range was 5–92 years with a mean age of 43 (±17) years. Eleven participants (13 eyes) had corneal blindness with a prevalence of 1.1% (95% confidence interval: 0.5–1.7). Corneal blindness accounted for 9.6 and 20.4% of bilateral and unilateral blindness, respectively. The prevalence of corneal blindness in the communities was greater among the male respondents, the older age groups, the farmers and the participants with lower educational status. The major causes of corneal blindness in the study were post-microbial keratitis (36.4%) and trauma (27.2%). Conclusion: Corneal blindness is still a major cause of both unilateral and bilateral blindness. Preventive measures for corneal blindness need to be further strengthened. In addition, affordable and accessible corneal surgery facilities should be established.
Probing the response of Deinococcus radiodurans exposed to simulated space conditions

Abstract The extremotolerant bacterium Deinococcus radiodurans is used as a model to explore the limits of life on Earth and beyond. In experiments performed in an ultra-high vacuum chamber with a vacuum ultraviolet (VUV) synchrotron beamline, this microorganism was exposed to conditions present on an extraterrestrial environment unprotected by an atmosphere, such as outside a spacecraft or on an asteroid, relevant in the context of planetary protection and panspermia hypothesis. Different methods were used to obtain the biologically relevant information from this investigation. Counting of colony forming units, the traditional approach for viability assessment, is limited to measuring the survival of the cells. For a more in-depth study of damage mechanisms at subcellular levels, specific molecular probes (propidium iodide and dihydrorhodamine 123) were applied and whole populations could be analysed, cell by cell, by flow cytometry. VUV radiation caused a substantial loss of viability, though only a fraction of the cells presented membrane damages even at the largest tested fluences. Additionally, intracellular oxidative stress was also detected upon exposure. These results point to significant VUV inactivating effects extending beyond the cells' outermost structures, in contrast to a more superficial role that could be expected due to the highly interacting nature of this radiation range. Nevertheless, it was observed that microscopic-level shading sufficed to allow the persistence of a small surviving subpopulation for the longer expositions. This study contributes to unveiling the response of biological systems under space conditions, assessing not just cell viability but also the mechanisms that lead to inactivation.
Gross Anatomical Observations on the Sacrum of Guinea Pig (Cavia porcellus)

Sacrum of guinea pig was triangular in shape. Sacrum was formed by fusion of four and three sacral vertebrae in male and female guinea pigs respectively. Adorsal sacral and two lateral sacral crests were present on the dorsal surface of sacrum. Wings presented an articular area in the lower part of its lateral aspect for the ilium. Anterior articular processes were present and faced upwards. Slender transverse processes were two at the caudal part of sacrum and projected backwards. Sacral spinal canal had a cranial triangular opening whereas posteriorly resembled an aperture. The number of dorsal and ventral sacral foramina differed in both the sexes. The morphometric measurements namely, length and width of sacrum were measured.
Electronic structure of graphene/MoO3/CuPc interfaces

The interfacial electronic structures of graphene/copper phthalocyanine (CuPc) modified with MoO3 interlayers were investigated using x-ray and ultraviolet photoelectron spectroscopy. Strong p-doping effect has been observed on graphene due to deposition of MoO3 films, causing formation of surface dipole (eD) and shift of graphene Dirac point, and consequently altering the charge transfer at graphene/CuPc interface. The ionization energy of CuPc on the graphene/MoO3 substrate is about 4.97 eV. The interfacial energy level alignments are estimated based on the experimental photoelectron spectroscopy data. Finally, the present experimental data indicate that the height of the electron and hole injection barriers from CuPc to graphene/MoO3 are 1.98 and 0.32 eV, respectively.