Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring functional health literacy in Hungary: Validation of S-TOFHLA and Chew screening questions.

OBJECTIVES The first efforts to measure health literacy have recently started in Hungary, thus there remains a need for tools that can be effectively used in the clinical setting. The goal of the present study was two-fold: to validate tools for measuring functional health literacy in Hungary using the Short Test of Functional Health Literacy (S-TOFHLA) and the Chew screening measure, and to provide an overview of the health literacy level of the Hungarian population. METHODS The original English versions of both instruments were translated following the principles of cultural adaptation and standardized translation methods. The measures were administered to a random sample (N = 302) that was close to representative of the Hungarian population regarding age, gender and educational background. The Newest Vital Sign functional health literacy test and numerous socio-demographic variables (such as age, gender, education and income) were also administered to test convergent validity. RESULTS The Hungarian version of the S-TOFHLA and the Chew questions showed adequate internal consistency. Lower functional health literacy scores showed the expected association with known predictors of health literacy: higher age, male gender and lower education. Especially people above 65 years of age and individuals with a low level of educational attainment or being chronically ill are vulnerable to have marginal health literacy. CONCLUSION The Hungarian version of the S-TOFHLA is a valid and reliable measure of health literacy. Moreover, the Hungarian version of the Chew screening questions provides a valid self-reported assessment, which is particularly useful to rapidly detect patients with inadequate health literacy in hospitals. It is expected that these health literacy measurements will be used for not only scientific purposes, but also serve as tools for developing public health policy, especially health education and campaigns reducing potential health disparities in Hungary.
A Method to Improve the Characteristics of EPDM Rubber Based Eco-Composites with Electron Beam

A natural fiber reinforced composite, belonging to the class of eco composites, based on ethylene-propylene-terpolymer rubber (EPDM) and wood wastes were obtained by electron beam irradiation at 75, 150, 300, and 600 kGy in atmospheric conditions and at room temperature using a linear accelerator of 5.5 MeV. The sawdust (S), in amounts of 5 and 15 phr, respectively, was used to act as a natural filler for the improvement of physical and chemical characteristics. The cross-linking effects were evaluated through sol-gel analysis, mechanical tests, and Fourier Transform Infrared FTIR spectroscopy comparatively with the classic method with dibenzoyl peroxide (P) applied on the same types of samples at high temperature. Gel fraction exhibits values over 98% but, in the case of P cross-linking, is necessary to add more sawdust (15 phr) to obtain the same results as in the case of electron beam (EB) cross-linking (5 phr/300 kGy). Even if the EB cross-linking and sawdust addition have a reinforcement effect on EPDM rubber, the medium irradiation dose of 300 kGy looks to be a limit to which or from which the properties of the composite are improved or deteriorated. The absorption behavior of the eco-composites was studied through water uptake tests.
The Association between Frailty and Uncorrected Refractive Error in Older Adults

ABSTRACT Purpose: Uncorrected refractive error (URE) is the leading cause of impaired vision in older adults and has been associated with adverse health outcomes. Here, we investigate the association between URE and frailty in older adults. Methods: This is a cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) participants ≥60 years (1999–2006 cycles). URE was defined as visual acuity worse than 6/12 that can be improved with correction, and prefrailty and frailty were defined as meeting 1–2 and ≥3 of 4 components of a modified physical frailty phenotype. The 5-item phenotype (including slowness) was analyzed in a subset of participants with available data. Propensity score adjustment was used to address the imbalance of potential confounders (including age) between URE groups. Results: In this sample (n = 5,265), 6% of participants had URE (n = 373). In fully adjusted propensity score-based models, individuals with URE were more likely to be prefrail (OR = 1.4; 95% CI: 1.0–2.0) and frail (OR = 3.2; 95% CI: 1.3–7.4) than those without URE using the 4-item phenotype. For the 2,486 participants with 5-item phenotype data, individuals with URE were more likely to be frail (OR = 3.0; 95% CI: 1.2–7.5); however, the association with prefrailty was not statistically significant (OR = 1.8; 95% CI: 0.9–3.6). Conclusion: In this population-based sample, older adults with URE were more likely to be frail than those without URE, even after rigorous control for confounders, including age.
Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA

Infection by Kaposi’s sarcoma-associated herpesvirus (KSHV) is necessary for the development of Kaposi’s sarcoma (KS), which most often develops in HIV-infected individuals. KS frequently has oral manifestations and KSHV DNA can be detected in oral cells. Numerous types of cancer are associated with the alteration of microbiome including bacteria and virus. We hypothesize that oral bacterial microbiota affects or is affected by oral KS and the presence of oral cell-associated KSHV DNA. In this study, oral and blood specimens were collected from a cohort of HIV/KSHV-coinfected individuals all previously diagnosed with KS, and were classified as having oral KS with any oral cell-associated KSHV DNA status (O-KS, n = 9), no oral KS but with oral cell-associated KSHV DNA (O-KSHV, n = 10), or with neither oral KS nor oral cell-associated KSHV DNA (No KSHV, n = 10). We sequenced the hypervariable V1-V2 region of the 16S rRNA gene present in oral cell-associated DNA by next generation sequencing. The diversity, richness, relative abundance of operational taxonomic units (OTUs) and taxonomic composition of oral microbiota were analyzed and compared across the 3 studied groups. We found impoverishment of oral microbial diversity and enrichment of specific microbiota in O-KS individuals compared to O-KSHV or No KSHV individuals. These results suggest that HIV/KSHV coinfection and oral microbiota might impact one another and influence the development of oral KS.
Seroprevalence of Toxoplasma gondii and Toxocara spp. infections among pregnant women with and without previous abortions in the west of Iran

In spite of the importance of toxoplasmosis and toxocariasis among the high‐risk groups, such as pregnant women, the infections are categorized as a neglected tropical disease by the World Health Organization. Toxoplasma gondii and Toxocara spp. infections can cause systemic and ocular diseases in infants during pregnancy. In this study, we investigated seroprevalence and risk factors of toxoplasmosis, toxocariasis and their co‐infection in pregnant women and non‐pregnant women referred to the healthcare facilities of Ilam province, west of Iran.
Association of TIM-3 with BCLC Stage, Serum PD-L1 Detection, and Response to Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

Considering the increasing importance of immune checkpoints in tumor immunity we investigated the clinical relevance of serum T-cell immunoglobulin and mucin domain-3 (TIM-3) in patients with hepatocellular carcinoma (HCC). Serum TIM-3 levels were measured and their association with HCC stage and the detection of serum programmed death ligand-1 (PD-L1) were assessed. In patients submitted to transarterial chemoembolization (TACE), pre- and 1-week post-treatment TIM-3 levels were also evaluated. We studied 53 HCC patients with BCLC stages: 0 (5.7%), A (34%), B (32.1%), C (22.6%), and D (5.7%). The patients with advanced HCC (BCLC C) had significantly higher TIM-3 levels than patients with BCLC A (p = 0.009) and BCLC B (p = 0.019). TIM-3 levels were not associated with HCC etiology (p = 0.183). PD-L1 detection (9/53 patients) correlated with TIM-3 levels (univariate analysis, p = 0.047). In 33 patients who underwent TACE, post-treatment TIM-3 levels (231 pg/mL, 132–452) were significantly higher than pre-TACE levels (176 pg/mL, 110–379), (p = 0.036). Complete responders had higher post-TACE TIM-3 levels (534 pg/mL, 370–677) than partial responders (222 pg/mL, 131–368), (p = 0.028). Collectively, TIM-3 may have a role in anti-tumor immunity following TACE, setting a basis for combining immunotherapy and chemoembolization.
Great Expectations: A Qualitative Analysis of the Factors That Influence Affective Forecasts for Exercise

The extent to which people expect to feel pleasure during exercise is proposed to influence an individual’s decision to be active. In order to identify the factors that shape this affective forecast for exercise, this study explored what people think about when creating their affective forecast for exercise. Thirty-one inactive participants provided an affective forecast for a moderate intensity exercise session using the global affective forecast questionnaire. Immediately after, they were asked a series of questions to verbally explain what they were thinking about in order to generate their forecast. Thematic analysis identified four themes relating to the exercise intensity, the exercise outcomes, the exercise environment, and the enjoyment of exercise that influenced affective forecast creation. Exercise practitioners should design strategies to manipulate these factors, and structure exercise environments to support a positive affective forecast and better motivate exercise participation.
Determining the Optimal Adjuvant Therapy for Improving Survival in Elderly Patients with Glioblastoma: A Systematic Review and Network Meta-analysis

Purpose: Older patients with glioblastoma (GBM) are underrepresented in clinical trials. Several abbreviated and standard chemoradiotherapy regimens are advocated with no consensus on the optimal approach. Our objective was to quantitatively evaluate which of these regimens would provide the most favorable survival outcomes in older patients with GBM using a network meta-analysis. Experimental Design: MEDLINE, Embase, Google Scholar, and the Cochrane Library were searched. Patients >60 years of age with histologically confirmed GBM were included. Primary outcome of interest was the pooled HR from randomized controlled trials (RCTs). Secondary outcomes of interest included pooled HR from studies controlling for MGMT promoter methylation status, and safety. Results: Fourteen studies, including 5 RCTs, reporting 4,561 patients were included. Using highest quality data from RCTs, our network-based approach demonstrated that standard radiotherapy (SRT) and temozolomide (TMZ) provided similar survival benefit when compared with hypofractionated radiotherapy (HRT) and TMZ [HR = 0.90; 95% confidence interval (CI), 0.43–1.87], TMZ alone (HR 1.25; 95% CI, 0.69–2.26), HRT alone (HR = 1.34; 95% CI, 0.73–2.45), or SRT alone (HR = 1.43; 95% CI, 0.87–2.36). HRT-TMZ had the highest probability (85%) of improving survival in older patients with GBM followed by SRT-TMZ (72%). Pooled analysis of trials controlling for MGMT promoter methylation status demonstrated that TMZ monotherapy confers similar survival benefit to combined chemoradiotherapy. Conclusions: Statistical comparisons using a network approach demonstrates that the common treatment regimens for older patients with GBM in previous RCTs confer similar survival benefits. Adjustments for MGMT promoter methylation status demonstrated that radiotherapy alone was inferior to TMZ-based approaches. Head-to-head comparison of TMZ monotherapy to combined TMZ and radiation is warranted.
Effects of mindfulness on psychological and psychophysiological responses during self-paced walking.

The aim of the present study was to investigate the effects of an audio-guided mindfulness (MF) single session on psychological and psychophysiological responses during an outdoor walking task. Twenty-four participants (12 females and 12 males; Mage = 23.6, SD = 3.9 years) were required to walk 200 m at a pace of their choosing. Two experimental conditions (mindfulness meditation and mindlessness [ML] meditation) and a control condition (CO) were administered. Electrical activity in the brain was measured by the use of a portable electroencephalography (EEG) system during walking. Fast Fourier Transform was used to decompose the EEG samples into theta (5-7 Hz), alpha (8-14 Hz), and beta (15-29 Hz) frequencies. Brain connectivity analysis between frontal and temporo-parietal electrode sites was conducted to explore functional interactions through the use of spectral coherence. Affective and perceptual responses were measured by the use of single-item scales and questionnaires. The present findings indicate that MF was sufficiently potent to reallocate attention toward task-related thoughts, downregulate perceived activation, and enhance affective responses to a greater degree than the other two conditions. Conversely, ML was sufficient to increase the use of dissociative thoughts, make participants less aware of their physical sensations and emotions, induce a more negative affective state, and upregulate perceived activation to a greater extent than MF and CO. The brain mechanisms that underlie the effects of MF on exercise appear to be associated with the enhanced inter-hemispheric connectivity of high-frequency waves between right frontal and left temporo-parietal areas of the cortex.
Social Influences on Binge Drinking in Emerging Adults: Which Social Network Members Matter Most?

Background Binge drinking peaks in emerging adulthood and is associated with a myriad of negative consequences. Research indicates that social network members have a significant influence on binge drinking. In particular, theory suggests that drinking habits of romantic partners and peers have a stronger influence on emerging-adult binge drinking than do drinking habits of siblings and parents. We investigated the relative influences of siblings, parents, romantic partners, and peers on emerging adults’ binge drinking using a multisource design and a robust measure of binge drinking. We hypothesized peer and romantic partner binge drinking would more strongly predict emerging-adult (egos) binge drinking than would parent and sibling binge drinking. Methods We recruited 321 participants (egos) aged 17–25 years, alongside 882 members of their social network (alters). Egos and alters completed self-report measures of binge drinking (frequency, quantity, and self-perception). Results Structural equation modeling revealed that the direct positive effect from romantic partner binge drinking to ego binge drinking was significant. In contrast, the direct effects from peer, parent, and sibling binge drinking to ego binge drinking were nonsignificant. Conclusion In emerging adulthood, romantic partners appear to have the strongest association with ego binge drinking.
Motor Program Transformation of Throwing Dart from the Third-Person Perspective

The perspective of perceiving one’s action affects its speed and accuracy. In the present study, we investigated the change in accuracy and kinematics when subjects throw darts from the first-person perspective and the third-person perspective with varying angles of view. To model the third-person perspective, subjects were looking at themselves as well as the scene through the virtual reality head-mounted display (VR HMD). The scene was supplied by a video feed from the camera located to the up and 0, 20 and 40 degrees to the right behind the subjects. The 28 subjects wore a motion capture suit to register their right hand displacement, velocity and acceleration, as well as torso rotation during the dart throws. The results indicated that mean accuracy shifted in opposite direction with the changes of camera location in vertical axis and in congruent direction in horizontal axis. Kinematic data revealed a smaller angle of torso rotation to the left in all third-person perspective conditions before and during the throw. The amplitude, speed and acceleration in third-person condition were lower compared to the first-person view condition, before the peak velocity of the hand in the direction toward the target and after the peak velocity in lowering the hand. Moreover, the hand movement angle was smaller in the third-person perspective conditions with 20 and 40 angle of view, compared with the first-person perspective condition just preceding the time of peak velocity, and the difference between conditions predicted the changes in mean accuracy of the throws. Thus, the results of this study revealed that subject’s localization contributed to the transformation of the motor program.
Social Processes Underlying Movement Influence: Young Adult Feminist Activists’ Interactions with Professionalized Feminist Organizations in Ecuador and Peru

ABSTRACT Despite extensive research on the influence between social movements, knowledge remains limited to the basic social processes by which this occurs. This article locates these social processes in the accounts among young adult feminist activists in Ecuador and Peru. Qualitative interviews were conducted and analyzed among 21 young adult feminist activists from eight groups. The findings show how their feminist mobilizing was influenced by interactions with professionalized feminist organizations that were simultaneously inclusive and exclusionary. Three in/exclusionary interactions captured basic social processes whereby young adult feminist activists struggled to define modes of participation, organizational practices, and targets of engagement.
Most Advanced yet Acceptable: A case of referential form-driven meaning innovation

Adopting a research-through-design approach we report a study to examine how radical departures from archetypal product form influence product meaning. We then consider implications for product acceptability. To achieve this we employ form theory to drive the design of three conceptual products. The three concepts were then prototyped and used as stimuli to gather participant responses to radical departures in product form from a dominant archetype. Results indicated the necessity of balance between typicality and novelty of form to achieve more acceptable meaning innovations. Specifically, results showed a requirement for maintaining inherent archetypal form characteristics and qualities, while at the same time providing opportunities for meaning change through radically novel form compositions, axis and balance. This approach to form-driven meaning change we tentatively term Referential Form-driven Meaning Innovation (RFMI). Implications for the application of the RFMI approach both in practice and as conceptual departure point for further studies are finally discussed.
Chapter 12 ARE ECOSYSTEM MODELS AN IMPROVEMENT ON SINGLE-SPECIES MODELS FOR FISHERIES MANAGEMENT ? THE CASE OF UPPER GULF OF CALIFORNIA , MEXICO

We review the recent applications of ecosystem models (EMs) as tools for fisheries management in the Upper Gulf of California (UGC), Mexico. EMs are compared with single-species model applications in the UGC, as a basis for assessing the benefits of each ecosystem model as a tool for evaluating management alternatives capable of diminishing impacts on marine ecosystems. The strengths and weaknesses of different types of EMs and their ability to evaluate the systemic mechanisms underlying observed shifts in resource production are also examined with respect to Ecosystem-Based Fisheries Management (EBFM) general goals. Findings showed that ecosystem modeling has increasingly resulted in support for EBFM in the UGC. However, outputs also proved evidence on that EMs are facing a most complicated situation than single-species models regarding the lack of data. Thus, the step from single-species models to EMs is a stage of the management of the area that does not require the elimination of the first approach, but rather the use of both approaches in a complimentary manner. The challenge is the integration of current ecosystem information to detect the gaps in the collective ∗ Corresponding author: Tel. : +52 646 174 5925; fax: +52 646 174 4560. E-mail address: ileana.espejel@uabc.edu. mx (I. Espejel) Alejandro Espinoza-Tenorio, Matthias Wolff and Ileana Espejel 2 knowledge on the UGC. Insights from this study are valuable in defining a planning model scheme that supports ecosystem-based management policies in local fisheries.
International Journal of Engineering Technology and Scientific Innovation

The perceptual integration of 50and 250-Hz, 500-ms vibrotactile and auditory tones was studied in detection experiments as a function of the relative phase (0 ̊, 72 ̊, 144 ̊, 216 ̊, and 288 ̊) of the tone pulses. Vibrotactile stimuli were delivered through a single-channel vibrator to the left middle fingertip and auditory stimuli were presented diotically through headphones in a background of 50 dB SPL broadband noise. The observers were four adults with normal hearing. The vibrotactile and auditory stimulus levels used each yielded 63-77%-Correct unimodal detection performance in a two-interval two-alternative forced-choice task. Scores for the auditory-alone and tactile-alone conditions averaged roughly 70%-Correct. Mean scores for the auditory plus tactile conditions averaged across different phases were 77.1%-Correct at 50 Hz and 79.6%-Correct at 250 Hz. At 50 Hz, no differences in performance were observed as a function of the relative phase at which the combined auditory and tactile signals were presented. At 250 Hz, significantly higher scores were observed for one phase combination (72 ̊) compared to two of the other four relative phases. Performance on the auditory plus tactile conditions resulted in significant integrative effects and was generally more consistent with a "Pythagorean Sum" model than with either an "Algebraic Sum" or an “Optimum Single Cannel” model of perceptual integration.
AIMS: The diameter of the posterior atrium of the lateral cerebral ventricles (PALV) does not vary substantially in size during foetal development and has thus become a stable marker for the identification of foetal ventriculomegaly

34 35 AIMS: The diameter of the posterior atrium of the lateral cerebral ventricles (PALV) does not vary substantially in size during foetal development and has thus become a stable marker for the identification of foetal ventriculomegaly developed countries. Currently, the accepted upper limit of PADLV is 10 mm. Ventricular atrial diameters greater than 10mm require more radiological evaluation to rule out ventriculomegaly. The aim of this study was to establish the normal range of values for the posterior atrium [PA] of foetal lateral ventricles in our environment and to determine a cut off value for prenatal diagnosis of ventriculomegaly. METHODS: The mean of two measurements was obtained from the transverse diameter of the atrium of the lateral ventricles of foetuses that met the inclusion criteria, as part of the routine obstetric ultrasound scan at the antenatal clinic or ultrasound suite of radiology department of the University College Hospital (UCH), Ibadan. The SPSS version 15 was used to analyse the data obtained. RESULTS: The mean posterior atrial diameter [PAD] of the lateral ventricl was 6.5mm with standard deviation (SD) 1.3mm and mean ±2SD 3.9 – 9.1mm. Male foetuses had larger atrial diameters than female. Student’s t-test and Pearson’s correlation coefficient were used to explore association. CONLUSION: With the existing resources in our environment, prenatal screening for ventriculomegaly during routine obstetric scan is achievable. Measurement of 10mm is a reasonable upper limit of normal in our environment. Foetuses with larger values need further evaluation to rule out hydrocephalus. 36