Miracle-dz/UniFAR-FTUs huggingface dataset:
Can psychological capital promote safety behaviours? A systematic review

Objectives.Occupational health and safety (OHS) is a relevant issue for many systems and stakeholders. This systematic literature review aims to expand knowledge on this topic starting from the integrated safety model (ISM) and to evaluate the role of psychological capital (PsyCap) on safety behaviours (SBs) (i.e., safety performance and prevention of occupational accidents and injuries). Methods. A total of 2704 studies was initially identified in the Scopus, PsycINFO and Web of Science databases. After rigorous screening, 20 empirical studies were included. Results. The results showed the relevant contribution of PsyCap in promoting SBs as a direct antecedent, a mediator between organizational factors and SBs or a moderator between job demands and SBs. Conclusion. Findings indicate that when workers feel resourceful, they feel also more confident and engaged, and, in turn, more focused on safety issues. Moreover, the results sometimes turn out to be contradictory, showing the dark side of personal resources. Considering these results, a plan to monitor and develop PsyCap could be implemented to promote SBs and safety environment. Indeed, PsyCap can be an essential individual resource for behaving safely also by reducing job demands’ perceptions and improving safety leadership.
Clinical bracket failure rates between different bonding techniques: a systematic review and meta-analysis

Summary Background Bracket failure increases the treatment time of orthodontic therapy and burdens patients with unnecessary costs, increased chair time, and possible new appointments. Objective To compare the bond failures of different orthodontic materials based on the results of available clinical studies. Search methods A systematic search of clinical trials was performed in the Cochrane, Embase, and Pubmed databases with no limitations. The list of investigated techniques contained conventional acid-etch primer (CM-AEP), self-etch primer (SEP), self-cure resin (SCR), and simple or resin-modified glass ionomer (RM-GIC) materials and procedures. Selection criteria Clinical studies reporting the failure rate of bonded brackets after using direct adhesive techniques on buccal sites of healthy teeth were included. Data collection and analysis Bracket failure rates from eligible studies were extracted by two authors independently. Risk ratios (RRs) were pooled using the random-effects model with DerSimonian–Laird estimation. Results Thirty-four publications, involving 1221 patients, were included. Our meta-analysis revealed no significant difference in the risk of bracket failures between SEP and CM-AEP. After 6, 12, and 18 months of bonding, the values of RR were 1.04 [95% confidence interval (CI), 0.67–1.61], 1.37 (95% CI, 0.98–1.92), and 0.93 (95% CI, 0.72–1.20), respectively. At 18 months, bracket failure was 4.9 and 5.2% for SEP and CM-AEP, respectively. Heterogeneity was good or moderate (I2 < 42.2%). The results of RM-GIC at 12 months indicated a 57% lower risk of bracket failure using SCR as compared with RM-GIC (RR: 0.38; 95% CI, 0.24–0.61). At 18 months, bracket failures for SCR and RM-GIC were 15.8 and 36.6%, respectively (RR: 0.44; 95% CI, 0.37–0.52, I2 = 78.9%), demonstrating three to six times higher failure rate than in the case of etching primer applications. Limitations A major limitation of the present work is that the included clinical trials, with no exceptions, showed variable levels of risk of bias. Another possible problem affecting the outcome is the difference between the clustering effects of the split mouth and the parallel group bracket allocation methods. Conclusions and implications The results revealed no significant difference between SEP and CM-AEP up to 18 months after application. RM-GIC had much worse failure rates than acid-etching methods; additionally, the superiority of SCR over RM-GIC was evident, indicating strong clinical relevance. Registration Prospero with CRD42020163362.
CN MORPHOLOGY STUDIES OF COMET 103P/HARTLEY 2

We report on narrowband CN imaging of Comet 103P/Hartley 2 obtained at Lowell Observatory on 39 nights from 2010 July until 2011 January. We observed two features, one generally to the north and the other generally to the south. The CN morphology varied during the apparition: no morphology was seen in July; in August and September, the northern feature dominated and appeared as a mostly face-on spiral; in October, November, and December, the northern and southern features were roughly equal in brightness and looked like more side-on corkscrews; in January, the southern feature was dominant but the morphology was indistinct due to very low signal. The morphology changed smoothly during each night and similar morphology was seen from night to night. However, the morphology did not exactly repeat each rotation cycle, suggesting that there is a small non-principal axis rotation. Based on the repetition of the morphology, we find evidence that the fundamental rotation period was increasing: 16.7 hr from August 13 to 17, 17.2 hr from September 10 to 13, 18.2 hr from October 12 to 19, and 18.7 hr from October 31 to November 7. We conducted Monte Carlo jet modeling to constrain the pole orientation and locations of the active regions based on the observed morphology. Our preliminary, self-consistent pole solution has an obliquity of 10° relative to the comet's orbital plane (i.e., it is centered near R.A. = 257° and decl. = +67° with an uncertainty around this position of about 15°) and has two mid-latitude sources, one in each hemisphere.
Towards a new horizon of optoelectronic devices with liquid crystals

The liquid crystal having high viscosity is attracting increasing attention as a new type of quality organic semiconductor, i.e., self-organizing molecular semiconductor. In this article, its state-and-the-art in materials, properties related to charge carrier transport, and device applications, is reviewed briefly. In addition, the further researches needed towards its practical applications are discussed.
On group topologies and unitary representations of inductive limits of topological groups and the case of the group of diffeomorphisms

T he purpose o f th is paper is tw ofo ld . T he first one is to discuss various group topologies on inductive lim its o f topological groups, a n d unitary representations of inductive limit groups in a certain case, and the second one is to treat group topologies in the case of the group o f diffeomorphisms. Contrary to the affirmative statement in [1] o r in [5], the inductive lim it of topologies of an inductive system o f topological groups does not always give a group topology, or m ore exactly, the multiplication is not necessarily continuous with respect to the inductive limit topology (denoted by r i d ) . In P art I of this paper, we show this by a simple example in the case of abelian groups, and then discuss in general which kinds of group topologies can be chosen on an inductive limit group under the condition that they are weaker than T Hid • W e study in particular the case where inductive system is countable and essentially consists of locally compact g roups. (F or exact definition, see §2.3. and such a system is called a countable L C G inductive system in s h o r t ) . Then we prove that the inductive limit topology r,„d gives a group topology in this case (Theorem 2.7), and also that it is essentially a unique one under a mild condition (Theorem 5.6). Further, for a countable LCG inductive system, we discuss in a certain extent unitary representations and continuous positive definite functions of the inductive limit group G = lim G and prove that, under the same condition as for Theorem J 5.6, there exist sufficiently many of them so that the points of G can be separated (Theorem 5.7). Since there does not exist in general a Haar measure o n G, the important point of the discussion is the limiting process from the case of locally compact groups GI t o G. In Part II, we discuss the case of the group G =Diffo (M ) of diffeomorphisms with compact supports on a connected, non-compact, Cr-manifold M , 1 < r < co, a n d prove that the inductive limit topology T j n d never g ives a group topology (Theorem 6.1).
Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank

The causes that trigger the onset of dementia are still unknown. Recently there has been an increasing interest in the possible role of infectious agents in the brain in the pathogenesis of this condition. Amongst the viruses, members of the Herpesviridae family, namely herpes simplex virus-1 (HSV1), cytomegalovirus (CMV), human herpesvirus-6 (HHV6), human herpesvirus-7 (HHV7) and varicella zoster virus (VZV) have been suggested as potential causes of the disease. However, the relative importance of these and other viruses in contributing to dementia remains unclear. We evaluated the association between seropositivity status of all viruses available in a large, population-based dataset (the UK Biobank) and dementia risk in an unbiased way. Of the 15 viruses investigated, our results showed a statistically significant increase of dementia risk associated only with HSV1 seropositivity (OR 2.14, 95% C.I. 1.21–3.81). However, by combining the data we found that seropositivity for 4 viruses (HSV1, HHV6, HHV7 and VZV) also significantly increases the risk of dementia (OR = 2.37, 95% C.I. 1.43–3.92). These four viruses have been described previously as neurotropic viruses. Our results provide support for a role for neurotropic viruses in the pathology of dementia.
Meat and interpersonal motives: the case of self-enhancement

ABSTRACT Meat eaters have a more hierarchical, less egalitarian view at the world than vegetarians. This can be manifested in social dominance orientation, at the intergroup level, but also at the interspecies level, yielding more empathy with nonhuman animals, and at the interpersonal level. We examined if interpersonal motives in human–human relationships and empathy with people are associated with frequency of meat eating, using a cross-sectional survey (N = 580). For the motives power and affiliation, no significant relationships emerged, but the self-enhancement motive was positively related to the number of days that participants ate meat. This predicted additional variance over and above variables at the intergroup and interspecies level, such as social dominance orientation and human-animal continuity. Empathy with people was negatively related to meat consumption, but this was explained by its correlation with empathy with animals. Discussion focuses on the importance of the self-enhancement motive in attachment to meat, the symbol of human superiority, as well as resistance to meat refusers.
Drug reaction with eosinophilia and systemic symptoms with features resembling Stevens–Johnson syndrome/toxic epidermal necrolysis related to apalutamide

Dear Editor, Apalutamide is an androgen receptor antagonist recently approved for the treatment of metastatic, castrationsensitive and nonmetastatic, castrationresistant prostate cancer. Skin rash is a commonly reported adverse event among patients exposed to apalutamide, with incidence rates reported at 27.1% and 23.8% for the TITAN and the SPARTAN trials, respectively. However, the incidence rate for skin rash reaches as high as 50% among the Japanese subpopulation, with a small number of cases developing lethal severe cutaneous adverse reactions (SCARs). 5 We report two cases of drug reaction with eosinophilia and systemic symptoms (DRESS) with large areas of skin detachment after apalutamide exposure confirmed by the International Registry of SCARs (RegiSCAR) group. Case 1: An 85yearold man with prostate cancer developed a pruritic skin rash 4 weeks after initiating oral apalutamide (240 mg/day). No other new medications were prescribed during the prior 3 months. Apalutamide was discontinued on the fourth day following skin eruption. Physical examination on admission revealed a generalized erythematous maculopapular rash with fever, facial oedema and periorbital sparing (Figure 1a). Laboratory tests demonstrated atypical lymphocytes, eosinophilia (21.3% of white cell count, 8.86 k/μl), and liver and pancreatic enzymes 3fold the normal upper limits. Serology tests and cultures excluded other infectious and autoimmune causes. Painful erythroderma and large f laccid blisters with a positive Nikolsky sign subsequently developed (Figure 1b,c). Skin biopsy revealed severe interface Received: 24 May 2022 | Accepted: 5 October 2022
Performance of the Swiss Digital Contact-Tracing App Over Various SARS-CoV-2 Pandemic Waves: Repeated Cross-sectional Analyses

Background Digital proximity-tracing apps have been deployed in multiple countries to assist with SARS-CoV-2 pandemic mitigation efforts. However, it is unclear how their performance and effectiveness were affected by changing pandemic contexts and new viral variants of concern. Objective The aim of this study is to bridge these knowledge gaps through a countrywide digital proximity-tracing app effectiveness assessment, as guided by the World Health Organization/European Center for Prevention and Disease Control (WHO/ECDC) indicator framework to evaluate the public health effectiveness of digital proximity-tracing solutions. Methods We performed a descriptive analysis of the digital proximity-tracing app SwissCovid in Switzerland for 3 different periods where different SARS-CoV-2 variants of concern (ie, Alpha, Delta, and Omicron, respectively) were most prevalent. In our study, we refer to the indicator framework for the evaluation of public health effectiveness of digital proximity-tracing apps of the WHO/ECDC. We applied this framework to compare the performance and effectiveness indicators of the SwissCovid app. Results Average daily registered SARS-CoV-2 case rates during our assessment period from January 25, 2021, to March 19, 2022, were 20 (Alpha), 54 (Delta), and 350 (Omicron) per 100,000 inhabitants. The percentages of overall entered authentication codes from positive tests into the SwissCovid app were 9.9% (20,273/204,741), 3.9% (14,372/365,846), and 4.6% (72,324/1,581,506) during the Alpha, Delta, and Omicron variant phases, respectively. Following receipt of an exposure notification from the SwissCovid app, 58% (37/64, Alpha), 44% (7/16, Delta), and 73% (27/37, Omicron) of app users sought testing or performed self-tests. Test positivity among these exposure-notified individuals was 19% (7/37) in the Alpha variant phase, 29% (2/7) in the Delta variant phase, and 41% (11/27) in the Omicron variant phase compared to 6.1% (228,103/3,755,205), 12% (413,685/3,443,364), and 41.7% (1,784,951/4,285,549) in the general population, respectively. In addition, 31% (20/64, Alpha), 19% (3/16, Delta), and 30% (11/37, Omicron) of exposure-notified app users reported receiving mandatory quarantine orders by manual contact tracing or through a recommendation by a health care professional. Conclusions In constantly evolving pandemic contexts, the effectiveness of digital proximity-tracing apps in contributing to mitigating pandemic spread should be reviewed regularly and adapted based on changing requirements. The WHO/ECDC framework allowed us to assess relevant domains of digital proximity tracing in a holistic and systematic approach. Although the Swisscovid app mostly worked, as reasonably expected, our analysis revealed room for optimizations and further performance improvements. Future implementation of digital proximity-tracing apps should place more emphasis on social, psychological, and organizational aspects to reduce bottlenecks and facilitate their use in pandemic contexts.
Machine Learning Applied to Patient‐Reported Outcomes to Classify Physician‐Derived Measures of Rheumatoid Arthritis Disease Activity

Patient‐reported outcome (PRO) data have assumed increasing importance in the care of patients with rheumatoid arthritis (RA), yet physician‐derived disease activity measures, such as Clinical Disease Activity Index (CDAI), remain the most accepted metrics to assess disease activity. The possibility that newer longitudinal PRO data might be used as a proxy for the CDAI has not been evaluated.
LHC phenomenology of general SU(2)xSU(2)xU(1) models

General SU(2)xSU(2)xU(1) models represent a well-motivated intermediate step towards the unification of the Standard Model gauge groups. Based on a recent global analysis of low-energy and LEP constraints of these models, we perform numerical scans of their various signals at the LHC. We show that total cross sections for lepton and third-generation quark pairs, while experimentally easily accessible, provide individually only partial information about the model realized in Nature. In contrast, correlations of these cross sections in the neutral and charged current channels may well lead to a unique identification.
T‐cell receptor αβ + double‐negative T cells in the kidney are predominantly extravascular and increase in abundance in response to ischemia–reperfusion injury

T‐cell receptor+CD4−CD8− double‐negative (DN) T cells are a population of T cells present in low abundance in blood and lymphoid organs, but enriched in various organs including the kidney. Despite burgeoning interest in these cells, studies examining their abundance in the kidney have reported conflicting results. Here we developed a flow cytometry strategy to clearly segregate DN T cells from other immune cells in the mouse kidney and used it to characterize their phenotype and response in renal ischemia–reperfusion injury (IRI). These experiments revealed that in the healthy kidney, most DN T cells are located within the renal parenchyma and exhibit an effector memory phenotype. In response to IRI, the number of renal DN T cells is unaltered after 24 h, but significantly increased by 72 h. This increase is not related to alterations in proliferation or apoptosis. By contrast, adoptive transfer studies indicate that circulating DN T cells undergo preferential recruitment to the postischemic kidney. Furthermore, DN T cells show the capacity to upregulate CD8, both in vivo following adoptive transfer and in response to ex vivo activation. Together, these findings provide novel insights regarding the phenotype of DN T cells in the kidney, including their predominant extravascular location, and show that increases in their abundance in the kidney following IRI occur in part as a result of increased recruitment from the circulation. Furthermore, the observation that DN T cells can upregulate CD8 in vivo has important implications for detection and characterization of DN T cells in future studies.
Using ISARIC 4C mortality score to predict dynamic changes in mortality risk in COVID-19 patients during hospital admission

As SARS-CoV-2 infections continue to cause hospital admissions around the world, there is a continued need to accurately assess those at highest risk of death to guide resource use and clinical management. The ISARIC 4C mortality score provides mortality risk prediction at admission to hospital based on demographic and physiological parameters. Here we evaluate dynamic use of the 4C score at different points following admission. Score components were extracted for 6,373 patients admitted to Barts Health NHS Trust hospitals between 1st August 2020 and 19th July 2021 and total score calculated every 48 hours for 28 days. Area under the receiver operating characteristic (AUC) statistics were used to evaluate discrimination of the score at admission and subsequent inpatient days. Patients who were still in hospital at day 6 were more likely to die if they had a higher score at day 6 than others also still in hospital who had the same score at admission. Discrimination of dynamic scoring in those still in hospital was superior with the area under the curve 0.71 (95% CI 0.69–0.74) at admission and 0.82 (0.80–0.85) by day 8. Clinically useful changes in the dynamic parts of the score are unlikely to be associated with subject-level measurements. Dynamic use of the ISARIC 4C score is likely to provide accurate and timely information on mortality risk during a patient’s hospital admission.
Gestational weight gain adequacy among twin pregnancies in France

Abstract The objective of this paper is to describe gestational weight gain (GWG), to assess the applicability of the 2009 Institute of Medicine (IOM) guidelines, and to derive a GWG adequacy classification within a French cohort. We included twins from the national, prospective, population‐based JUmeaux MODe d'Accouchement (JUMODA) cohort study (2014–2015). Following the IOM approach, we selected a ‘standard’ population of term pregnancies with ‘optimal’ birthweight (≥2500 g; n = 2562). GWG adequacy (insufficient; adequate; excessive) was defined using IOM recommendations (normal body mass index [BMI]: 16.8–24.5 kg [also utilized for underweight BMI]; overweight: 14.1–22.7 kg; obese: 11.4–19.1 kg). Additionally, using the IOM approach, we determined the 25th and 75th percentiles of GWG in our standard population to create a JUMODA‐derived GWG adequacy classification. GWG and GWG adequacy were described, overall and by BMI and parity. In the JUMODA standard population of term twin livebirths with optimal birthweight, mean GWG was 16.1 kg (standard deviation 6.3). Using IOM recommendations, almost half (46.5%) of the women had insufficient and few (10.0%) had excessive GWG, with similar results regardless of BMI or parity. The 25th and 75th percentiles of GWG in the JUMODA standard population (underweight: 13–21 kg; normal weight: 13–20 kg; overweight: 11–19 kg; obese: 7–16 kg) were lower than the IOM recommendations. The IOM recommendations classified a relatively high percentage of French women as having insufficient and a low percentage as having excessive GWG. Additional research to evaluate recommendations in relation to adverse perinatal outcomes is needed to determine whether the IOM recommendations or the JUMODA‐derived classification is more appropriate for French twin gestations.