Miracle-dz/UniFAR-FTUs huggingface dataset:
BRAF Inhibitors in BRAF-Mutated Colorectal Cancer: A Systematic Review

Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths globally. BRAF mutation is present in about 10% of CRC patients and is associated with a poor response to chemotherapy. These patients have a relatively poor prognosis. This review aims to assess the efficacy and safety of BRAF inhibitors in BRAF-mutated CRC patients. A literature search was performed on PubMed and Embase, and clinical trials relevant to BRAF inhibitors in CRC were included. Data were extracted for efficacy and safety variables. Two randomized clinical trials (n = 765) and eight non-randomized trials (n = 281) were included based on inclusion criteria. In RCTs, an overall response was reported in 23% of the patients treated with BRAF inhibitor-based regimens compared to 2.5% with control regimens. The hazard ratio of overall survival was also significantly better with triplet encorafenib therapy at 0.52 (95% CI = 0.39–0.70). In single-arm trials, ORR was 17% and 34% in two-drug and three-drug regimens, respectively. BRAF inhibitor-based regimens were safe and effective in the treatment of BRAF-mutated CRC. Large-scale randomized trials are needed to find a suitable population for each regimen. PROSPERO registration No. CRD42023471627.
Perceived Effects of Orthognathic Surgery versus Orthodontic Camouflage Treatment of Convex Facial Profile Patients

Increased facial profile convexity has a common occurrence in the population and is a primary reason for seeking orthodontic treatment. The present study aimed to compare the perceived changes in facial profile appearance between patients treated with combined orthognathic/orthodontic treatment versus only orthodontic camouflage treatment. For this reason, 18 pairs of before- and after-treatment facial profile photos per treatment group (n = 36 patients) were presented to four types of assessors (surgeons, orthodontists, patients, laypeople). Ratings were recorded on 100 mm visual analogue scales depicted in previously validated questionnaires. All rater groups identified minor positive changes in the facial profile appearance after exclusively orthodontic treatment, in contrast to substantial positive changes (14% to 18%) following combined orthodontic and orthognathic surgery. The differences between the two treatment approaches were slightly larger in the lower face and the chin than in the lips. The combined orthodontic and orthognathic surgery interventions were efficient in improving the facial appearance of patients with convex profile, whereas orthodontic treatment alone was not. Given the significant influence of facial aesthetics on various life aspects and its pivotal role in treatment demand and patient satisfaction, healthcare providers should take these findings into account when consulting adult patients with a convex facial profile.
Fat Intake in Overweight Adolescents with Health Belief Model Approach

Obesity in childhood is associated with early mortality, psychiatric, and cardiometabolic comorbidities, and is likely to remain into adulthood. One of the most often utilized models in health-related research to describe and predict behavioral health is the Health Belief Model. The current research aims to ascertain the link between adolescent fat intake and all HBM components. The design of this study was cross-sectional. Purposive sampling was the sampling method, and 110 participants from 4 secondary schools were included. The research data were analyzed using SPSS 27. Measurement of fat intake using a 24-hour food recall interview with two repetitions on non-consecutive days. HBM measurement using questionnaires with 59 questions representing 6 HBM constructs. The bivariate test was performed with the Spearman and Pearson tests. Variables significantly related to fat intake are cues to action and self-efficacy. The higher the cues to action, the lower the adolescent fat intake. Likewise, the higher the self-efficacy, the less fat intake in adolescents. HBM-based education is needed to increase adolescents' perceptions and beliefs regarding health problems, especially overweight, to support handling overweight issues in adolescents.
Cutaneous Leishmaniasis: Endemic Regions and Epidemiological Characteristics of Cases Declared at University Hospital Center of Tlemcen, Algeria, 2012-2016

Cutaneous leishmaniasis (CL) is a widespread parasitic disease and a public health problem worldwide. It is an endemic and notifiable disease in Algeria. Our objective was to know the epidemiological characteristics and to determine the endemic regions of the CL in the town of Tlemcen. A descriptive study was conducted with a prospective collection over five years, from 2012 to 2016, based on the systematic declaration of CL cases received from the various departments of the University Hospital center (UHC) of Tlemcen. Data entry and analysis was done by Epi-info 6 software. Thirty-four cases of cutaneous leishmaniasis, 27 of which are autochthonous were reported at the UHC of Tlemcen during 5 years with a female predominance; sex ratio (h/f): 0.79. The most affected age group was 40-50 years old. Six cases occurred in children under 16 years, 80% of the reports were received by the dermatology department. The highest peak was recorded in 2013; autumnal predominance was noted in 30% of cases. All patients lived or had been in endemic areas. Vector control campaigns must be reinforced to fight against leishmaniasis in the town of Tlemcen, also, the improvement of habitat conditions for populations at risk.
REGENERATION OF HETERODENDRUM IN ARID SOUTH-EASTERN AUSTRALIA

: Work was carried out to see if the failure of Heterodendrum oleifolium to regenerate vegetatively and from seed in the arid zone is due to grazing, the physical environment, innate factors or some combination of these. Flowering and seed set were spasmodic in the study area. Insect predators destroyed up to 68 per cent of seed in the crowns. Many unattacked seeds were empty and the proportion of empty seeds appeared to increase with time from seed set. Enhanced germination after seed coat nick¬ ing demonstrated some hard-seededness. Sucker shoots can arise from shallow, horizontal roots. Detached root pieces produced callus tissue but not suckers. Young plants readily produced stem suckers after decapitation. After root severance, callus swellings were common, but root suckcring was rare. In the Held, severance of roots by ploughing produced root suckers distal to the site of severance, suggesting control of suckering by the shoot apex. After wildfire, 19 per cent of mature trees were killed, mostly those smaller than 50 cm girth, while 30 per cent formed root suckers. At all sites, virtually all root suckering could be readily related to specific disturbance events and so was considered episodic. Isoenzyme analysis to test genetic identity indicated that the frequently observed groves of H. oleifolium were clonal. Because suckcring seems strongly dependent on disturbance, it is suggested that simply removing stock will not allow adequate regeneration. Management may need to provide sufficient fire frequency to initiate enough suckers for replacement of old stems and hence stand perpetuation.
Cooling effect of an Antarctic climate on man : with some observations on the occurence of frostbite

Illtroduction . General description of cl imate Heat exchange and wind chill Materials and methods . Data and results Temperature . Wind speed . Radiation . Wind chill at Maudheim . Calculation of mean wind chill index . Wind chill during sledging journeys . Mean wind chill indices for other antalctic stations . Discussion . Use of mean values for \Vind chill . Relative level of mean wind chill at :\Iaudheim . Con tri bu ti on of solar radiation . Wind chill conditions during sledging . Frostbites Selection of cases . Wind chill and frostbite . Rate of occurrence . Summary . Acknowledgements . Referenees . Page 5 5 5 7 10 12 12 12 14 14 15 17 19 19 19 21 23 24 26 26 27 27 29
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE-/- Mice

Novel components of the mitochondrial fission machinery, mitochondrial dynamics proteins of 49 kDa (MiD49) and 51 kDa (MiD51), have been recently described, and their potential therapeutic targets for treating cardiovascular disease have been shown, including acute myocardial infarction (AMI), anthracycline cardiomyopathy and pulmonary arterial hypertension (PAH). Here, we examined the role of MiD49 and MiD51 in atherosclerosis. MiD49/51 expression was increased in the aortic valve endothelial cells (ECs) of high-fat diet-induced atherosclerosis in ApoE-/-mice and IL-8-induced human umbilical vein endothelial cells (HUVECs), which accelerated dynamin-related protein 1 (Drp1)-mediated mitochondrial fission. Silencing MiD49/51 reduced atherosclerotic plaque size, increased collagen content, and decreased the IL-8-induced adhesion and proliferation of HUVECs. MiD51 upregulation resulted from decreased microRNA (miR)-107 expression and increased hypoxia-inducible factor-1a (HIF-1a) expression. Treatment with miR-107 mimics decreased atherosclerotic plaque size by reducing HIF-1α and MiD51 production. Both MiD49 and MiD51 were involved in atherosclerotic plaque formation through Drp1-mediated mitochondrial fission, and the involvement of MiD51 in this process was the result of decreased miR-107 expression and increased HIF-1α expression. The miR-107–HIF-1α–MiD51 pathway might provide new therapeutic targets for atherosclerosis.
Predictors of depressive symptoms during pregnancy

Background: Pregnancy is one of the most prominent changes for many women and for some it represents a period of elevated anxiety, stress, and depressive symptoms which create health risks for both women and their offspring. While the risk factors for postpartum depression have been extensively studied, the predictors of depression during pregnancy have been far less explored. Even though depression is recognized as an important health issue, it is still a relatively neglected component of pregnancy care. The aim of this research was twofold: (1) to examine the prevalence of depressive symptoms during pregnancy and (2) to investigate whether anxiety (general and pregnancy-specific), perceived stress, coping strategies, self-esteem, perceived social support, and sociodemographic and obstetric data were significant predictors of depression symptoms during pregnancy. Method: Pregnant women (N=310) participated in the study in the 32nd week of pregnancy on average. They were approached at a prenatal clinic Protection and promotion of the well-being of children, youth, and families 156 where they filled in the following questionnaires: the Edinburgh Postnatal Depression Scale (EPDS), a short version of the Depression, Anxiety and Stress Scales (DASS-21), the Pregnancy Concerns Scale (PCS) as a measure of pregnancy-specific anxiety, the Coping Orientation to Problems Experienced (COPE), the Rosenberg Self-Esteem Scale (RSES), the Social Support Appraisal Scale (SS-A) as a measure of social support from family and friends, the Perceived Support from Partner Scale (PSPS), and the sociodemographic and obstetric sheet. Results: Results showed that 10-13% of the women had elevated depressive symptoms and the most important factor in predicting depressive symptoms during pregnancy was the higher levels of stress. Additional risk factors included state anxiety, avoidance as a style of coping with stress, low self-esteem, and a history of depression symptoms. Conclusion: These findings have implications for the development of intervention programmes with the aim of identifying high-risk women and making their pregnancy and upcoming transition to motherhood a healthier and more positive life experience.
Coronary Tortuosity Index vs. Angle Measurement Method for the Quantification of the Tortuosity of Coronary Arteries in Non-Obstructive Coronary Disease

Coronary tortuosity has been recognized as a potential pathophysiological mechanism in the development of non-obstructive coronary artery disease (CAD). The aim of this study was to examine the role of two coronary tortuosity measurement methods in the detection of clinically significant coronary tortuosity. The study included 160 patients with angina symptoms and myocardial ischemia detected by cardiac stress tests in chronic settings and those diagnosed with acute coronary syndrome. After coronary angiography, tortuosity of coronary arteries was assessed by two methods, including measurement of tortuosity angles and calculating of tortuosity index. Significantly more tortuous coronary arteries were detected in the group with non-obstructive CAD (p < 0.01 for all three arteries), with significantly higher tortuosity index (TI) for all three coronary arteries in this group of patients, compared to patients with obstructive CAD. The highest TI for LCX was found in patients with lateral ischemia (p < 0.001) and for LAD in patients with anterior ischemia (p < 0.001). When measured by the angle method, the only association was found between LCX tortuosity and lateral ischemia (OR 4.9, p = 0.046). In conclusion, coronary tortuosity represents a pathophysiological mechanism for myocardial ischemia in non-obstructive CAD. The coronary tortuosity index could be a reliable and widely applicable tool for the quantification of coronary tortuosity.
Effective operators on an attractive magnetic edge

— The semiclassical Laplacian with discontinuous magnetic field is considered in two dimensions. The magnetic field is sign changing with exactly two distinct values and is discontinuous along a smooth closed curve, thereby producing an attractive magnetic edge. Various accurate spectral asymptotics are established by means of a dimensional reduction involving a microlocal phase space localization allowing to deal with the discontinuity of the field. Résumé (Opérateurs effectifs sur une discontinuité magnétique). — Cet article s’intéresse au laplacien avec champ magnétique discontinu dans la limite semi-classique. Le champ est supposé prendre exactement deux valeurs non nulles de signes opposés et changer de signe le long d’une courbe fermée et régulière, la « frontière magnétique ». Nous établissons diverses asymptotiques spectrales à l’aide d’une réduction de dimension mettant en jeu une localisation dans l’espace des phases et permettant de traiter la discontinuité du champ magnétique.
Ilio-Iliac Arteriovenous Fistula with May-Thurner Syndrome: A Case Report

An ilio-iliac arteriovenous fistula (AVF) is rare. Common factors leading to ilio-iliac AVF include congenital malformations, iatrogeny, and trauma. There is limited documentation in the literature of cases involving ilio-iliac AVF with May-Thurner syndrome. Here, we present a case of an ilio-iliac AVF with May-Thurner syndrome in an 80-year-old male. CT and angiography confirmed extensive ilio-iliac AVF. Successful endovascular procedures for ilio-iliac AVF were performed using several variable-sized coils and 1400–2000 µm gelatin particles. After embolization, follow-up abdominopelvic CT revealed an improvement in edema in the left leg.
A Biomechanical Simulation of Forearm Flexion Using the Finite Element Approach

Upper limb movement is vital in daily life. A biomechanical simulation of the forearm with consideration of the physiological characteristics of the muscles is instrumental in gaining deeper insights into the upper limb motion mechanisms. In this study, we established a finite element model of the forearm, including the radius, biceps brachii, and tendons. We simulated the motion of the forearm resulting from the contraction of the biceps brachii by using a Hill-type transversely isotropic hyperelastic muscle model. We adjusted the contraction velocity of the biceps brachii muscle in the simulation and found that a slower muscle contraction velocity facilitated forearm flexion. Then, we changed the percentage of fast-twitch fibers, the maximum muscle strength, and the neural excitation values of the biceps brachii muscle to investigate the forearm flexion of elderly individuals. Our results indicated that reduced fast-twitch fiber percentage, maximum muscle strength, and neural excitation contributed to the decline in forearm motion capability in elderly individuals. Additionally, there is a threshold for neural excitation, below which, motion capability sharply declines. Our model aids in understanding the role of the biceps brachii in forearm flexion and identifying the causes of upper limb movement disorders, which is able to provide guidance for enhancing upper limb performance.
Evaluation of different surface treated implants after provisionalization: A 6-month prospective study

Background. Replacing missing teeth with dental implants has become the best treatment option; therefore, clinicians need to understand the predictability of the treatment. Surface treatment of implants is one of the methods to improve osseointegration, thus improving the quality of treatment. Increasing esthetic awareness among patients has led to the popularity of immediate provisionalization of dental implants. This study investigated the effect of surface treatment on implant stability when loaded with immediate non-functional temporary prostheses and compared the superiority of one surface treatment over the other in terms of osseointegration by evaluating implant stability quotient (ISQ). Methods. Twenty implants with different surface treatments were placed, i.e., resorbable blast media (RBM) surface and alumina blasted/acid-etched (AB/AE) surfaces. All the implants were non-functionally loaded, and ISQ was measured immediately after implant placement and 6 and 12 weeks after non-functional loading. Crestal bone levels, mPI, mSBI, and peri-implant probing depths were compared for both groups at 1, 3, and 6 months. Results. At 12 weeks, all the implants showed desirable ISQ, indicating successful osseointegration. The increase in ISQ at 12 weeks was significantly higher for RBM implants compared to baseline, indicating a more predictable course of osseointegration. Crestal bone levels recorded at 1, 3, and 6 months did not significantly differ between the groups. All other parameters showed comparable values for both groups at all intervals. Conclusion. Replacing missing teeth with dental implants with immediate non-functional restorations is a predictable treatment option.
Transcriptome Analysis Revealed the Early Heat Stress Response in the Brain of Chinese Tongue Sole (Cynoglossus semilaevis)

Simple Summary Temperature is a pervasive environmental factor that plays a crucial role in the lives of aquatic organisms. However, the mechanisms governing the response to temperature remain unclear in teleost fish. In this research, the marine benthic fish Chinese tongue sole (Cynoglossus semilaevis), which is economically significant in northern China, is used as a model to analyze this issue. The brains of female and male C. semilaevis were examined via transcriptomics technology to investigate their response to temperature. Our findings revealed the existence of specific genes and pathways involved in cortisol synthesis and secretion, neuroactive ligand–receptor interactions, TGF-beta signaling pathway, and JAK/STAT signaling pathway. The genes identified includes the HSP family, tshr, c-fos, c-jun, cxcr4, camk2b, and igf2. Our study provides some evidence that C. semilaevis responds to temperature, highlighting a potential path for further investigation. Abstract As a common influencing factor in the environment, temperature greatly influences the fish that live in the water all their life. The essential economic fish Chinese tongue sole (Cynoglossus semilaevis), a benthic fish, will experience both physiological and behavioral changes due to increases in temperature. The brain, as the central hub of fish and a crucial regulatory organ, is particularly sensitive to temperature changes and will be affected. However, previous research has mainly concentrated on the impact of temperature on the gonads of C. semilaevis. Instead, our study examines the brain using transcriptomics to investigate specific genes and pathways that can quickly respond to temperature changes. The fish were subjected to various periods of heat stress (1 h, 2 h, 3 h, and 5 h) before extracting the brain for transcriptome analysis. After conducting transcriptomic analyses, we identified distinct genes and pathways in males and females. The pathways were mainly related to cortisol synthesis and secretion, neuroactive ligand–receptor interactions, TGF beta signaling pathway, and JAK/STAT signaling pathway, while the genes included the HSP family, tshr, c-fos, c-jun, cxcr4, camk2b, and igf2. Our study offers valuable insights into the regulation mechanisms of the brain’s response to temperature stress.
Scaling oxygen microprofiles at the sediment interface of deep stratified waters

Dissolved oxygen microprofiles at the sediment‐water interface of Lake Geneva were measured concurrently with velocities 0.25 to 2 m above the sediment. The measurements and scaling analyses indicate dissolved oxygen fluctuations and turbulent fluxes in exceedance of molecular diffusion in the proximity of the sediment‐water interface. The measurements allowed the parameterization of the turbulent diffusion as a function of the dimensionless height above the sediment and the turbulence above the sediment‐water interface. Turbulent diffusion depended strongly on the friction velocity and differed from formulations reported in the literature that are based on concepts of turbulent and developed wall‐bounded flows. The dissolved oxygen microprofiles and proposed parameterization of turbulent diffusion enable a foundation for the similarity scaling of oxygen microprofiles in proximity to the sediment. The proposed scaling allows the estimation of diffusive boundary layer thickness, oxygen flux, and oxygen microprofile distribution in the near‐sediment boundary layer.
Study of Coffee Bean Displacement Inside Drum Roaster Using Force Balance Analysis

The drum roaster's design and operating method significantly affect the coffee roasting process. The coffee bean displacement inside the drum roaster can be observed to compare the drum roaster's different designs and operating methods. The coffee bean movement is crucial since it affects the heat transfer distribution among coffee beans inside the drum roaster. The more dynamic displacement of coffee beans gives more even heat distribution. Force balance analysis can be used to predict the coffee bean displacement since it can predict particle movement with mutable variables. This paper compares the coffee bean displacement inside the drum roaster with flippers and without flippers using simple force balance analysis. The analysis involves tangential force, centrifugal force, frictional force, and the beans' weight itself. The analysis shows that the radius of the drum roaster (r) and angular acceleration (ω) significantly change the resultant force's dynamic, and the various tilt angle of flippers (β) did not too significantly affect it. The bigger radius (r) and angular acceleration (ω) generate a stronger centrifugal force influencing the bean's equilibrium. The direction change of force resultant applied to the bean is more smooth in the drum with flippers than without flippers. Keywords: Coffee bean displacement, Drum coffee roaster, Force balance analysis, Resultant force Turning point duration