Miracle-dz/UniFAR-FTUs huggingface dataset:
Modification of olmesartan on time-frequency distribution in QRS and expression of TIMP-1 mRNA in spontaneously hypertensive rat's heart

Aging changes of the time–frequency distribution (TFD) during QRS by use of continuous wavelet transform (CWT) observed at spontaneously hypertensive rats(SHR/Izm) hearts were studied with and without the administration of angiotensin II receptor blocker (ARB). The remodeling of the left ventricles was evaluated by histological and quantitative real-time RT-PCR analyses. The integrated time-frequency powers of ARB-treated SHR/IZM were less decreased over wide frequency range (180-500 Hz) but were tended to be increased in low frequency ranges (80 Hz or less) compared with those of control SHR/zm. The extracellular fibrous tissue was decreased in ARB-treated SHR/Izm than in control group. The present study provides the evidence that TFD of QRS complex partly reflects the suppressive action of ARB on age-dependent progression of cardiac remodeling in the heart.
Amino Acid Transport in Rat Liver and Morris Hepatomas: Effect of Protein Diet and Hormones on the Uptake of a-Aminoisobutyric Acid-14Â«:1

SUMMARY The uptake of a-aminoisobutyric acid-14C, a nonmetabolizable amino acid, was compared for Morris hepatomas 5123C, 7800, 9633, and 9618A with that of host and normal liver from rats on controlled feeding regimens. The effect of the dietary protein level, hydrocortisone, and glucagon treat ment and adrenalectomy on the uptake of the amino acid by the individual hepatomas and liver was also examined. The purpose of this study was to ascertain whether alterations occurred in the amino acid transport system of the hepatomas and to explore the possibility that transport changes might provide an explanation for the diversity in the activity of amino acid metabolizing enzymes reported for these tissues. Uptake of a-aminoisobutyric acid-14 C by Hepatoma 7800 was as great as that of the host liver despite the limited circulation of the hepatoma. A diversity in the concentrative capacity of the amino acid was observed for the hepatomas studied. The uptake by Hepatoma 5123C was 4- to 5-fold greater than host and normal livers, while Hepatoma 7800 showed an uptake about twice that of liver. Hepatoma 9633 showed the same uptake as the host and normal livers, while Hepatoma 9618A showed one-fourth the uptake of liver. protein had no effect on rats fed a 30% protein diet. A complex relationship was also observed between the dietary protein level and the effect of hydrocortisone and glucagon treatment on the uptake of the amino acid by normal liver. A diversity was observed in the response of the amino acid transport system of the diploid hepatomas to hydrocortisone
SPECIAL ISSUE OF L1-EDUCATIONAL STUDIES IN LANGUAGE AND LITERATURE READING: A CRITICAL CONCEPTUAL ANALYSIS COMMENTS ON FIVE CONTRIBUTIONS

In this issue there are five contributions concerning decoding ability, linguistic competence and its implications for reading instruction and reading research. I want to begin by stating that I am not an expert in this specific area of reading research. However, that being said the main focus in my research has been reading comprehension. I do think this circumstance may be an advantage since on one hand I am not involved in the particular debate on different positions regarding reading instruction. On the other hand I do have a fair share of experience from reading research. My comments will focus on the structure and the consistency of some of the arguments made.
Biological flora of Central Europe

Himantoglossum adriaticum H. Baumann is a long-lived perennial orchid with an adriato- 30 mediterranean distribution. The species-level separation of this species from the more 31 geographically widespread H. hircinum has only recently been confirmed via a combination 32 of molecular and morphometric techniques, which are further developed here. To provide a 33 comprehensive overview of its autecology we integrated previously published information 34 with extensive unpublished data derived mainly from populations in the Keszthely Hills of 35 Hungary. In this paper we assess the distribution, habitat preferences, life history and seed 36 germination (ex situ and in situ) of H. adriaticum , with special emphasis on its reproductive 37 biology.
The Status of STEM Living Communities

Virtually all institutions of higher learning have developed activities and/or academic programs in the Science, Technology, Engineering and Math disciplines, i.e., STEM. One specific program is called “STEM Living Learning Communities. ” Living learning communities are a kind of co-registration or block scheduling that enables students to take courses together where the same students register for two or more courses, forming a sort of study team. 13 Living learning communities are defined as programs in which undergraduate students live together in a discrete portion of a residence hall or the entire hall and participate in academic and/or extra-curricular programming designed specifically for them. 5 These programs can look different depending on the size of the institution; the needs, values, and beliefs of the students; and those individuals facilitating the program. 1 Typically, living learning communities are centered on a common theme, require that students reside in a central residential, and are enrolled in related disciplines. Students who choose to reside in these living learning communities share similar interests and due to their living proximity they are more likely to go through the same educational and campus life experiences. The overall goal of these learning living communities is to stimulate greater educational success through academic and social endeavors. Working together, students and faculty members in living learning communities have the opportunity to form a stronger bonds. Students can share personal feelings allowing faculty members to listen and become aware of how to best assist the student with their personal learning goals. 3,4 The authors of this study conducted a national pilot study in order to examine how STEM living learning communities are formulated; how well they retain students; to measure how STEM living learning community students are functioning socially and academically; to discover what programs are being offered to students at STEM living learning communities; to learn how involved faculty members are in living communities; and to check the status of STEM freshman programs at different universities. The drivers of this study were to document higher academic success and retention rates.
Rediscovering the Virgin Lands

Against the global debate on socially responsible agro-investment, we explore the conditions, patterns, and impacts of recent agricultural recovery in Kazakhstan’s northern grain provinces. Vertically and horizontally integrated agroholdings brought outside investment and management to this region. With stable employment in agriculture, real consumption spending of rural households has doubled within an eightyear period. Due to the socialist tradition of industrialised farming operations, rural inhabitants regard themselves primarily as workers and not as land owners. We conclude that investment in large-scale farming can provide benefits to rural people even with less than ideal-type political representation.
The Reversible Inhibition of Catatase Activity by Nucleotides and Its Possible Relationship to Mouse Liver Catatase Depression Induced by Biological Substances1

The early temporal responses of mouse liver and kidney catatase (EC 1.11.1.6, H2O2:H202 oxidoreductase) were examined following i.p. administration of heterologous protein and glycoproteins, bacterial endotoxin, bradykinin, allylisopropylacetylcarbamide, talcum, 3-amino-l,2,4-triazole, and Ehrlich ascites tumor and fluid extracts. With the exception of Ehrlich ascites tumor, all substances examined showed depression of mouse liver catalase activity 0.5 to 3 hr after administration, although not as pronounced as that of 3-amino-l,2,4-triazole. Nucleotides added to purified human hepatic catalase, mouse liver, and human erythocyte catalases resulted in the inhibition of catalatic activity. AMP and its related diand triphosphate nucleotide esters appeared to be most effective in the inhibition of catalatic activity. Coenzymes I and II both reduced catalatic activity, and the oxidized forms and UMP esters also demonstrated inhibition of catalatic activity. The inhibition of catalatic activity by these nucleotides was immediate and reversible. With the exception of glutathione and reduced forms of coenzymes I and II, the nucleotides had no effect on peroxidatic activity. It is suggested that inhibition of catalatic activity may be mediated in part by nucleotides during normal and abnormal metabolic processes in the liver.
NF-kappa B-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells

Lower respiratory tract infections are among the most common causes of death worldwide. Main pathogens leading to these severe infections are viruses and gram-positive bacteria that activate toll-like receptor (TLR)mediated immune responses via pathogen-associated molecular patterns. One protective factor induced during infection is Chitinase-3-like 1 (CHI3L1), which exerts various functions, e.g. in host cell proliferation and bacterial counteraction, and has been proposed as a biomarker in several acute and chronic inflammatory conditions. MicroRNAs (miR) have become important regulators of inflammation and infection and are considered therapeutic targets in recent years. However, it is not known whether microRNAs play a role in the regulation of CHI3L1 expression in TLR-mediated respiratory epithelial cell inflammation. In this study, we analysed the preand post-transcriptional regulation of CHI3L1 by TLRs in bronchial epithelial cells. Therefore, we stimulated BEAS-2B cells with the bacterial TLR2-ligand lipoteichoic acid or the viral dsRNA analogue poly(I:C). We observed an increase in the expression of CHI3L1, which was dependent on TNF-α-mediated NF-κB activation in TLR2and TLR3-activated cells. Moreover, TLR2 and− 3 stimulation caused downregulation of the microRNA miR-149-5p, an effect that could be suppressed by inhibiting NF-κB translocation into the nucleus. Luciferase reporter assays identified a direct interaction of miR-149-5p with the CHI3L1 3 ́untranslated region. This interaction was confirmed by inhibition and overexpression of miR-149-5p in BEAS-2B cells, which altered the expression levels of CHI3L1 mRNA. In summary, miR-149-5p directly regulates CHI3L1 in context of TLRmediated airway epithelial cell inflammation and may be a potential therapeutic target in inflammation and
DNA polymorphisms at α-Gpdh locus of Drosophila melanogaster in Korean population

Restriction site variation in 18-kb region including the Gpdh (sn-glycerol-3-phosphate dehydrogenase) locus has been assessed in 27 isofemale lines, 12 lines from the Chounan population and 15 lines from the Pusan population in Korea. Of the 25 restriction sites that were scored, 5 sites were polymorphic (20.0%): PstI (–2.35), XbaI (–1.7), HindIII (0.0), HindIII (+0.25), and PstI (+5.7). Two insertions (I) and three deletions (D) were detected. All the restriction sites and length polymorphisms were located in introns and outside regions of the Gpdh structure gene, the area from –7.0 site to –5.5 site. The proportion of segregating nucleotides, p, for all 27 lines was 0.019 and the estimated heterozygosity per nucleotide pair, was 0.013. Sixteen kinds of restriction map haplotypes of all lines analyzed were detected. Few lines were identical at the restriction map level. The estimated haplotype diversity, h, was 0.968. The haplotype diversity (0.997) of Gpdh bearing chromosomes was slightly higher than that (0.982) of Gpdh chromosomes. Analysis for a linkage disequilibria between the polymorphism also showed that HindIII (+0.25) vs. I (a) and PstI (–2.35) vs. D (a) have relatively high level of the linkage disequilibria. There were no significant relationship between restriction site polymorphism and GPDH activity in 27 second-chromosome lines; however, there was an apparent difference in the effect of length variation on GPDH activity. The activity of deletion-bearing lines was lower than that of deletion-free lines, while there was no effect of insertion on activity. Duplication of Gpdh was observed in about one-third of the 27 isofemale lines. The duplication-bearing lines in both populations had higher levels of GPDH activity and GPDH CRM than duplication-free lines. In a further investigation of the duplication structure, the duplication of Korean populations was shown to have a similar structure to other populations investigated (Symonds and Gibson, 1992; Takano et al., 1989).
Superiority Effect in Detecting Phylogenetic Threats Under Unattentional Condition: A Visual Mismatch Negativity Study

Rapid and accurate perception of threat information is a critical ability and a prerequisite to survive natural selection for humans. To investigate whether threatening stimuli, especially phylogenetic and ontogenetic threats, are processed automatically, we analyzed the visual mismatch negativity (vMMN, an event-related potential component reflecting automatic processing) elicited by the threats with a cross-modal oddball paradigm, where participants were required to focus on the auditory stimuli and ignore the visual stimuli in each block. In this study, neutral (non-threatening) images served as standard stimuli (80%), and phylogenetic (10%) and ontogenetic (10%) threat stimuli served as deviant stimuli when testing a large sample (N = 96) of healthy volunteers. Threat-related visual mismatch negativity (threat-vMMN) was obtained by subtracting the event-related potential (ERP) elicited by standard stimuli from that elicited by deviant stimuli. The results indicated that the vMMN can be elicited by threat information. More importantly, the phylogenetic threat information elicited larger threat-vMMN than ontogenetic threat information. These findings suggest that perception of threat information was automatic, providing an evidential basis for the attentional advantages of survival processing. That is, automatic perception of phylogenetic threats has a particular evolutionary origin.
Implementation of Good Corporate Governance Mechanisms on Family Firm Performance in Indonesia

The aim of this study is to examine the relationship of good corporate governance on family firms’ performance in Indonesia.This study used 125 of family companies on Indonesia Stock Exchange from 2010 to 2014 as a sample size.This study contributes to literature on family corporate governance and firm performance. Empirical evidence leads the family corporate governance and firm performance with mixed results.This study focuses of companies who have at least 20% shareholders or more which own by families.The findings reveal that board size and debt has a positive relationship with family firm performance.Larger board size is give more resource and has high solving problem capabilities than smaller board of director.However, board commissioner of independent does not contribute to firm value.Further, manager who has high portion managerial ownership would lead these managers concern on personal interest rather than firm’s interest.Next, Debt help financial problem in companies while running the business and achieve the high performance and small size of company enhance the firm performance.Further, this finding is to enrich the literatures on family corporate governance and firm performance especially in Indonesia.
for future applications

we]]-studied protein, functions a monomer, where the biased binding to MT, which 1eads to force-generation, observed both in vitro and in si]ico experiments. Cryo-electren microscopy indieated KIFIA to the a-P contact region within the dimmer (intra-dimer binding site), there is another almost equivatent potentiat bindingsitebetweentheadjacentdirnrners{inter-dimeTbindingsite),Ithasbeenindicated that the binding-site selectivity is achieved by the difYbrence in the KIF1A-MT electrostatic interaction between the intra- and inter-dimer binding sites. On the other hands. ofKIF1A to the inter-dirner binding site was also observed in our previous simulation study using a residue-based grained. However, it is possible that the binding-site selectivity eursimulationduetothecoarse-grainingoftheproteinmodel.Therefore,inthis study, we examined this possibitity by using the al]-atom model, and calculated the binding energy between KIF1A and the aP tubulin dimmer, We found that the binding energy for KIFIA binding to the intra-dimer binding site is tower the inter-dimer binding site, We then analyzed the binding energy at the residue level, and examined whether the observed bjnding-energy di fference is originated electrostatie the critical ro]e Eoop 7 of KIF1A as suggested).
CONTINUOUS PROGRAMMING CONTAINING ARBITRARY NORMS

Optimality conditions and duality results are obtained for a class of cone constrained continuous programming problems having terms with arbitrary norms in the objective and constraint functions. The proofs are based on a Fritz John theorem for constrained optimization in abstract spaces. Duality results for a fractional analogue of such continuous programming problems are indicated and a nondifferentiable mathematical programming duality result, not explicitly reported in the literature, is deduced as a special case. 1980 Mathematics subject classification (Amer. Math. Soc): 90 C 48, 90 C 30.
WTP for Luxury EVs and their Attributes: A Bayesian Approach to Highlight the Ecology Effect on DM

Sustainable and environmental friendly goods are daily gaining importance and responsiveness. This has pushed companies to acclimate their strategies into “green” policy. Even luxury manufacturers are concerned since this can wholly destroy the business and lead to customer churning. The risk is particularly high in this segment due to its sensitivity and to the intricate customer requirements. For instance, researchers like Bendell and Kleanthous, Kapferer and, Kapferer and Michaut [1-3] discussed the implications of ignoring these norms, even if clients do not acclaim them openly. Unlike regular merchandises, prosperous buyers have a deep liaison to their favorite brands due to the social, individual and functional benefits offered by luxury products [4-7]. This ‘loyalty’ suggests a forgiveness buffer when these companies partially lose their appeal or are temporary inferior relative to the competition. In other words, people are more likely to disregard some attributes to, further consume their desirable trademarks. For example, one would ignore a missing Navigation system in a Ferrari, but not in a Volkswagen. However, many uncertainties should be revealed: to which extent customers would forgive their favorable brands when ignoring some aspects such as sustainability and ecology? What are the car attributes that enhance the WTP and therefore loyalty? This work evaluates the key aspects and motivations for luxury electric car buyers. In addition, it models the tolerance level for manufacturers. Many arguments legitimize the choice of the automobile segment. First, the market share within luxuries is about 40% (€489 billion out of €1,2 trillion) in 2017 and shows a continuous growth of 8% compared to 2016 (Bain and company, 2017). Second, due to a low purchase frequency and to a high investment rate, people are more rational in their decisions. In addition, unlike fashion or jewelry, there is no discrimination effect since both genders appreciate cars and use them. Fourth, a car symbolizes the best way to project prosperity such as Status and prestige because they can only be consumed publicly. Finally, product experience (previous/ current) with a vehicle have generally a long cycle and shapes therefore the foundation for future choices [8,9]. For example, for someone who likes a specific car and had a pleasing experience with it, the next purchase is more likely to occur within the same brand. Even if the acquired product is the poorest in their evoked sets, it is expected that clients would ignore some features and needs toward savor the brand. Typically, this is what all brands implicitly strive for because it strengthens the true brand value through a forgiveness level. *Corresponding author: Houssam Jedidi, Johannes Gutenberg University of Mainz, Marketing Department (Prof. Dr. Oliver P. Heil (PhD.)), Jackob-Welder Weg. 9, Mainz, Rheinland-Pfalz, Germany. Received Date: July 24, 2019 Published Date: August 05, 2019 ISSN: 2687-8097 DOI: 10.33552/SJRR.2019. 02.000530
Concentration of Selected Heavy Metals in Water and the Cummulative Effect on Selected Organs of Oreochromis Niloticus and Clarias Gariepinus from Lake Victoria, Kenya

The presence of heavy metals in aquatic ecosystems has been of great concern because of their toxicity to man when their concentrations are more than the permissible levels. These metals enter the environment through different ways such as industrial activities. The objectives of the study were; to determine the concentrations of selected heavy metals (Cu, Cd and Zn) in water samples collected from three different study sites at the shores of Lake Victoria, Kenya, to determine the concentrations of the selected heavy metals in selected organs (muscles, liver, kidney, gills and intestines) of two fish species (O. niloticus and C. gariepinus) from the shores of Lake Victoria, and to determine whether there are significant differences in the levels of heavy metals among the selected organs of fish and the water from the Lake. Water samples were collected from the three sites (Kisat sewage discharge point, Molasses factory discharge point, and Coca-Cola factory discharge point) at approximately 0.2 m below the water surface using half-litre plastic (PVC) bottles. Five replicate samples were taken from each site. Immediately after sampling the samples were acidified with concentrated nitric acid then samples were stored in a cool box and transported to the laboratory for further processing. Fish samples were collected from the three sites using an electro-fisher, washed with deionized water, sorted by species, packed in polythene bags and transported to the laboratory in a cool box for further processing. The tissues of the organs were analyzed quantitatively using Atomic Absorption Spectrophotometer. Samples of fish organs were homogenized and diluted with distilled water before analysis. Single classification and three-way factorial ANOVA were used for statistical analyses. Statistical significance was declared at α =0.05. The findings of the present study revealed that the concentrations of heavy metals in water were not significantly different (P≤0.05) among sites. Cadmium ranged from 0.0290. 045 ug/L, Copper between 0.036-0.042 ug/L while zinc ranged between 0.039-0.113ug/L. The concentrations of heavy metals were significantly higher in fish organs than in water, similarly, concentrations of heavy metals differed significantly (P≤0.05) between species. The concentrations of heavy metals differed significantly among metal types and also among fish organs. In conclusion, all the tested organs of fish species caught in Lake Victoria were contaminated with heavy metals. The two fish species demonstrated different capacities to accumulate heavy metals. Similarly, different organs of fish demonstrated different capacities to accumulate heavy metals. There was a high prevalence of metal accumulation in different organs. Consumption of fish from industrial discharge points should be discouraged as it might contain high concentrations of heavy metals.