Miracle-dz/UniFAR-FTUs huggingface dataset:
A Prognostic Model Based on XRCC1 Gene Polymorphisms and Clinicopathological Factors to Predict One-Year Survival of Advanced Epithelial Ovarian Cancer Patients

Prognosis of advanced stage epithelial ovarian cancer (EOC) patients remains poor due to recurrence and disease progression after surgery and chemotherapy. Polymorphism in the genes involved in DNA repair, i.e. x-ray repair cross complementing protein-1 (XRCC1) and XRCC3 could alter function, diminish repair kinetics and may play a role in tumor resistance to therapy. This study was aimed to predict the prognosis of advanced stage EOC patients based on the polymorphism of XRCC1 and XRCC3 genes and the clinicopathology. This was an ambispective cohort study in EOC patients treated in Fatmawati General Central Hospital and its network hospitals in Jakarta between 2011 and 2016. Demographic data and clinicopathology was obtained from the medical record. Polymorphisms of XRCC1 and XRCC3 genes were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Survival analyses were performed using the Kaplan-Meier curve and Cox proportional hazard test. Multivariate analyses were performed to obtain prediction model for 1-year survival. Scoring system was developed and tested using the receiver operating characteristic (ROC) curve analyses. A total of 129 eligible cases were included. Patients’ mean age was 49.6 years. Most patients (93.8%) were having stage III disease. Mortality at 1-year was associated with three independent variables, i.e. histopathology subtype, residual tumor > 1 cm, and XRCC1 gene Arg399Gln polymorphisms (Arg/Gln or Gln/Gln alleles). These prediction models gave 85.3% accuracy by ROC curve analysis and 82.7% posttest probability. Prognosis of advanced stage EOC patients can be predicted from several clinicopathological factors and XRCC1 gene polymorphisms. Validation study is needed to confirm these findings.
An Assessment of Nonhydrostatic and Hydrostatic Dynamical Cores at Seasonal Time Scales in the Energy Exascale Earth System Model (E3SM)

In global atmospheric modeling, the differences between nonhydrostatic (NH) and hydrostatic (H) dynamical cores are negligible in dry simulations when grid spacing is larger than 10 km. However, recent studies suggest that those differences can be significant at far coarser resolution when moisture is included. To better understand how NH and H differences manifest in global fields, we perform and analyze an ensemble of 28 and 13 km seasonal simulations with the NH and H dynamical cores in the Energy Exascale Earth System Model global atmosphere model, where the differences between H and NH configurations are minimized. A set of idealized rising bubble experiments is also conducted to further investigate the differences. Although NH and H differences are not significant in global statistics and zonal averages, significant differences in precipitation amount and patterns are observed in parts of the tropics. The most prominent differences emerge near India and the Western Pacific in the boreal summer, and the central‐southern Indian Ocean and Pacific in the boreal winter. Tropical differences influence surrounding regions through modification of the regional circulation and can propagate to the extratropics, leading to significant temperature and geopotential differences over the middle to high latitudes. While the dry bubble experiments show negligible deviation between H and NH dynamics until grid spacing is below 6.25 km, precipitation amount and vertical velocity are different in the moist case even at 25 km resolution.
A MEMS Electrochemical Angular Accelerometer Leveraging Silicon-Based Three-Electrode Structure

This paper developed an electrochemical angular micro-accelerometer using a silicon-based three-electrode structure as a sensitive unit. Angular acceleration was translated to ion changes around sensitive microelectrodes, and the adoption of the silicon-based three-electrode structure increased the electrode area and the sensitivity of the device. Finite element simulation was conducted for geometry optimization where the anode length, the orifice diameter, and the orifice spacing of the sensitive unit were determined as 200 μm, 80 μm, and 500 μm, respectively. Microfabrication was conducted to manufacture the silicon-based three-electrode structure, which then was assembled to form the electrochemical angular micro-accelerometer, leveraging mechanical compression. Device characterization was conducted, where the sensitivity, bandwidth, and noise level were quantified as 290.193 V/(rad/s2) at 1 Hz, 0.01–2 Hz, and 1.78 × 10−8 (rad/s2)/Hz1/2 at 1 Hz, respectively. Due to the inclusion of the silicon-based three-electrode structure, compared with previously reported electrochemical angular accelerometers, the angular accelerometer developed in this article was featured with a higher sensitivity and a lower self-noise level. Therefore, it could be used for the measurement of low-frequency seismic rotation signals and played a role in the seismic design of building structures.
Prenatal Detection of Congenital Duodenal Obstruction—Impact on Postnatal Care

Background: Duodenal obstruction is a rare cause of congenital bowel obstruction. Prenatal ultrasound could be suggestive of duodenal atresia if polyhydramnios and the double bubble sign are visible. Prenatal diagnosis should prompt respective prenatal care, including surgery. The aim of this study was to investigate the rate and importance of prenatally diagnosed duodenal obstruction, comparing incomplete and complete duodenal obstruction. Methods: A retrospective, single-center study was performed using data from patients operated on for duodenal obstruction between 2004 and 2019. Prenatal ultrasound findings were obtained from maternal logbooks and directly from the investigating obstetricians. Postnatal data were obtained from electronic charts, including imaging, operative notes and follow-up. Results: A total of 33/64 parents of respective patients agreed to provide information on prenatal diagnostics. In total, 11/15 patients with complete duodenal obstruction and 0/18 patients with incomplete duodenal obstruction showed typical prenatal features. Prenatal diagnosis prompted immediate surgical treatment after birth. Conclusion: Prenatal diagnosis of congenital duodenal obstruction is only achievable in cases of complete congenital duodenal obstruction by sonographic detection of the pathognomonic double bubble sign. Patients with incomplete duodenal obstruction showed no sign of duodenal obstruction on prenatal scans and thus were diagnosed and treated later.
Comparison of muscle activity during swimming and on the Biokinetic simulator

Introduction: The aim of the study is to evaluate the coordination similarity ratio of involvement of selected muscles (m. pectoralis major; m. latissimus dorsi; m. obliquus externus abdominis; m. triceps brachii) during the crawl swimming cycle as a target movement with imitation movement act. The research set comprised 16 elite swimmers specializing in crawl sprint tracks. Methods: The key research method was surface electromyographic analysis synchronized with video recording. The study was based on a quantitative description of electromyographic recordings of the observed movement acts. The research study has the character of an intra-individual and inter-individual comparative analysis of the coordination characteristics of the movement system. This is a sequential triangulation of a quantitative-qualitative approach and an intragroup case study with an experimental way of obtaining data. Results: Muscle activation of selected muscles during the crawl did not show a significant difference in effect size compared to the imitation movements on the Biokinetic swimming simulator.
Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the protein kinase C inhibitor ruboxistaurin

Background Neutrophil extracellular traps (NETs) are web-like DNA and protein lattices which are expelled by neutrophils to trap and kill pathogens, but which cause significant damage to the host tissue. NETs have emerged as critical mediators of lung damage, inflammation and thrombosis in coronavirus disease 2019 (COVID-19) and other diseases, but there are no therapeutics to prevent or reduce NETs that are available to patients. Methods Neutrophils were isolated from healthy volunteers (n=9) and hospitalised patients with COVID-19 at the acute stage (n=39) and again at 3–4 months post-acute sampling (n=7). NETosis was measured by SYTOX green assays. Results Here, we show that neutrophils isolated from hospitalised patients with COVID-19 produce significantly more NETs in response to lipopolysaccharide (LPS) compared to cells from healthy control subjects. A subset of patients was captured at follow-up clinics (3–4 months post-acute sampling), and while LPS-induced NET formation is significantly lower at this time point, it remains elevated compared to healthy controls. LPS- and phorbol myristate acetate (PMA)-induced NETs were significantly inhibited by the protein kinase C (PKC) inhibitor ruboxistaurin. Ruboxistaurin-mediated inhibition of NETs in healthy neutrophils reduces NET-induced epithelial cell death. Conclusion Our findings suggest ruboxistaurin could reduce proinflammatory and tissue-damaging consequences of neutrophils during disease, and since it has completed phase III trials for other indications without safety concerns, it is a promising and novel therapeutic strategy for COVID-19. Proinflammatory neutrophil extracellular traps are increased during acute #COVID19 and can be reduced by the protein kinase C inhibitor and orally active drug, ruboxistaurin. https://bit.ly/3nH6sxD
THE IMPACT OF WORD OF MOUTH AND DISCOUNTS ON VISIT INTENTION WITH DESTINATION IMAGE AS INTERVENING ON TOURIST DESTINATIONS IN THE CITY OF BATAM

The Covid-19 pandemic has greatly impacted sectors in all corners of the world, especially in Indonesia. Since the lockdown, the government has forced the country to lock up from tourists both foreign and domestic, a large-scale closure in Indonesia resulting in a very significant decline in the tourism sector. In the last few months tourism has reopened, so marketers are competing to attract visitors with interesting promotions and reviews related to the destination including the City of Batam. This research is classified as explanatory research, namely, research that explains the relationship variables and tests the relationship between several variables through testing several hypotheses using an approach with SmartPLS version 3 software with 390 respondents using the Hair calculation method. The results of this study indicate that Destination image, Word of Mouth, and Discount has a significant positive effect on visit intention.
Prevalence of Parasitic Species in Ruminants Found in the Vicinity of Lahore, Pakistan

In Pakistan, the livestock industry is one of the most important subsectors of the agricultural industry as it offers a handsome share in gross domestic national growth. However, gastrointestinal parasitic infections are a serious concern for cattle managing organizations and farmers. These effects of gastrointestinal parasites may vary with the age, sex of cattle, nutritional practices, and the sever of contagion. So, there is a need to update knowledge on spatio-temporal differences and regulate practices to improve the health conditions of animals. The present study was conducted to estimate the prevalence of gastrointestinal parasites in bovine, caprine and ovine genera reared in and around Lahore. A total number of 160 fecal samples were collected from all different genera. To calculate the prevalence of parasites in different genera, all the samples were subjected to parasitological examination and analyzed through direct smear method. In general, an overall prevalence of 40% was recorded showing 64 samples were positive. The observed parasitic species were Balantidium coli (a parasitic protozoan), Fasciola hepatica (liver fluke), Coccidia (a microscopic protozoan), Shistosoma bovis (blood fluke), Ostertagia ostertagi (parasitic nematode), Trichuris globulosa (intestinal nematode), Haemonchus contortus (pathogenic nematode), Chabertia ovina (parasitic roundworms) and Strogyloides papillosus (parasitic nematode). Overall out of 160 total samples 64 samples were positive and 40% prevalence was recorded in all ruminants. Among bovines, (cows and buffaloes), the multi-parasites prevalence was recorded as 47.5 and 37.5%, respectively. However, in ovine (sheep) and caprine (goats), the prevalence was 42.5 and 32.5% respectively. The parasitic prevalence was observed alike in adults and young. The data showed a higher parasitic prevalence in adult bovine and ovine species as compared to caprine species. The study showed a significant difference (P value< 0.05) among adult and young groups of Balantidium coli in buffaloes, Fasicola hepatica in cows and Ostertagia ostertagi in goats. It was concluded that low occurrence of parasites in ovine and caprine species as compared to bovine species was due to proper care and deworming practices being used for these animals. Moreover, there is further need to consider different managerial control practices and awareness programs to control gastrointestinal parasitic infections. Copyright(c) The Authors
Study on mechanical and tribological characteristics of layered functionally graded polymer composite materials

It is apparent that well-designed functionally graded materials (FGMs) exhibit smooth transition in properties. In this paper, polymer based functionally graded composite materials (FGCMs) were developed in combination with copper (Cu) particles and epoxy. A novel stepped layer configuration through a curing-phase approach at each layer in three different curing conditions (C1, C2, C3) have been processed. A significant enhancement in mechanical strength and erosion resistance was observed at higher curing temperatures (60°C) for sample C3. The results indicated tensile and compressive strengths of C3 enhanced by 40.20%, 17.48% and 20.18%, 9.74% compared to C1 and C2, respectively. Furthermore, when the FGM is loaded from top to bottom (T-B), there is an enhancement in flexural strength of C3 by 7.88% when compared to bottom to top (B-T) loading. In addition, the erosion wear of C3 was found to be lowest of all the samples.
Supporting informal science learning with metacognitive scaffolding and augmented reality: effects on science knowledge, intrinsic motivation, and cognitive load

ABSTRACT Background Museums have been paying an increasing attention to the design of experiences conducive to informal learning. While spontaneous inquiries in museums often pique visitors’ intrinsic motivation to learn, certain structures or scaffolds are needed to facilitate sense making in museum learning. Two promising approaches are identified: metacognitive scaffolding and augmented reality (AR) that offer on-demand content and interactions. Purpose This study aimed to answer the following research question: Compared with metacognitive scaffolding alone, how does the access to additional AR content affect informal learning experiences in a science museum in terms of science content knowledge, intrinsic motivation, and cognitive load? Sample The sample of the study consisted of 63 sixth-grade students divided into two groups. The treatment group (31) received both metacognitive scaffolding and AR support in their museum visit, whereas the control group (32) received only metacognitive scaffolding. Design and methods A quasi-experimental research design was conducted. The independent variable was the treatment conditions, and the dependent variables were students’ science knowledge test performance, learning motivation, and cognitive load. The research instrument for this study included a science knowledge test, a learning motivation survey, and a perceived cognitive load questionnaire. Results The results revealed that the combination of metacognitive scaffolding and AR led the treatment group to significantly outcome the control group in the science knowledge post-test, but the effect did not last in the 2-week delayed retention test. The control group perceived more importance in the museum learning activity. No difference was found in cognitive load. Conclusions Metacognitive scaffolding may have an enduring impact on science learning in museums. The long-term impact of AR needs further investigation. Balance should be maintained between structure and open exploration to sustain intrinsic motivation in informal learning settings.
It's not late entry: human capital, welfare states and the pension penalty experienced by post-war migrants who retired in the European Economic Area

Abstract Since the 2000s, migration within and into the European Economic Area (EEA) has increased significantly. Some migrants will retire in their destination countries. This makes questions about their retirement protection increasingly relevant for social policy. To address this, we examine past experience. Using the Survey of Health, Ageing and Retirement in Europe (SHARE), we compared the pensions of post-1945 migrants, who settled in their host country, with non-migrants. We considered migrants who moved into and within the EEA, from poorer and richer countries. Where pensions were lower we sought to explain this in relation to the migration literature. As expected, we found some evidence that migrants’ pensions were lower, although significant variations were observed between EEA migrants and non-EEA migrants. However, surprisingly there were few indications that migrant pensions were lower because migrants as a whole were disadvantaged through late labour market entry or employment discrimination. Instead educational disadvantage mattered most, particularly for the highly educated: all highly educated migrants received lower rewards for their human capital than comparable non-migrants. Migrants who settled in countries with less-protective pension systems were also disadvantaged. Making retirement outcomes for migrants more equal would, thus, mean improving career opportunities for highly educated migrants and steps towards more-inclusive pension systems everywhere.
ANALYSIS OF THE FACTORS THAT INFLUENCE EMPLOYMENT AS ONLINE TRANSPORTATION DRIVERS IN BATAM CITY

The development of transportation always follows by technological developments. The impact given by changes in technological developments on online transportation is to provide opportunities for people to have new jobs. This research aims to analyze the influence of training, motivation, job stress, and job satisfaction on employee performance with employee engagement as a mediation. This study involves 400 employees of Gojek in Batam City. Using SmartPLS analysis, it was found that training is positive not significant on employee performance with employee engagement as mediation. Job stress is negative not significant on employee performance with employee engagement as mediation. Both motivation and job satisfaction has the most important role to enhance employee performance with employee engagement as mediation.
Transformation toward e-learning: experience from the sudden shift to e-courses at COVID-19 time in Central European countries; Students’ satisfaction perspective

This study aims to evaluate transforming toward online-learning, concerning students’ satisfaction, social presence and students’ intention to continue with e-learning in Central European countries, taking the case of Hungarian higher education online courses during COVID- 19 measures. This study finds that masters and undergraduate students’ satisfaction and social presence of online learning courses are neutral with little bias to be positive, also satisfaction has the key role in affecting student’s intention to continue with future online-learning.
Utility of plasma volume status in ambulatory patients with pulmonary hypertension

Abstract Plasma volume status (PVS) is a noninvasive estimate of intravascular volume status. We studied the utility of PVS to predict short‐term outcomes in patients with pulmonary hypertension. Patients with lower PVS had decreased risk of hospitalization and death within 90 days of clinic visit, compared to those with higher PVS.
Dynamics of the Queensland Fruit Fly Microbiome through the Transition from Nature to an Established Laboratory Colony

The transition from nature to laboratory or mass rearing can impose significant physiological and evolutionary impact on insects. The Queensland fruit fly (also known as ‘Qfly’), Bactrocera tryoni (Froggatt) (Diptera: Tephritidae), is a serious economic pest that presents major challenges for horticulture industries in Australia. The sterile insect technique (SIT) is being developed to manage outbreaks in regions that remain free of Qfly and to suppress populations in regions where this species is endemic. The biology of Qfly is intimately connected to its microbiome. Therefore, changes in the microbiome that occur through domestication have implications for SIT. There are numerous studies of the microbiome in Qfly larvae and adults, but there is little information on how the microbiome changes as Qfly laboratory colonies are established. In this study, high-throughput Illumina sequencing was used to assess the Qfly microbiome in colonies reared from wild larvae, collected from fruit, for five generations, on a gel-based larval diet. Beta diversity analysis showed that the bacterial communities from Generation 5 (G5) clustered separately from earlier generations. At the genus level, bacterial communities were significantly different between the generations and mostly altered at G5. However, communities were found similar at phyla to family taxonomic levels. We observed high abundance of Morganella and Burkholderia at the genus level in the larval and pupal stages respectively at G5, but these were not detected in earlier generations. Overall, our findings demonstrate that the domestication process strongly affects the Qfly microbiome and prompts questions about the functional relationship between the Qfly and its microbiome, as well as implications for the performance of insects that have been domesticated and mass-reared for SIT programs.
Characteristics of the Turkana Low-Level Jet Stream and the Associated Rainfall in Cmip6 Models

The Turkana low-level jet stream (TJ) is important to climatic conditions over northern Kenya and East Africa. The representation of the TJ in climate models varies due to the TJ interaction with Turkana channel that is influenced by model resolution and influences the model representation of the regional climate. This study compares features of the TJ in CMIP6 AMIP model simulations with ERA5. Models reveal wind speeds that match those of the reanalysis from the ERA5 at the jet entrance (13 m/s) but lower magnitudes of wind speed and vertical shears compared to ERA5 within the Turkana channel. The models with slowest wind speeds, have a flattened Turkana channel and fail to exhibit the terrain constriction at 37°E which otherwise aids in accelerating winds to form a jet core. Furthermore, they fail to represent the narrowing of the channel as in ERA5, thereby forming blocking walls in the channel, forcing vertical ascent and mixing, and weakening shear. Stronger ascent is conducive for rainfall formation, enhancing wet anomalies by up to 8% above the observed climatology at the exit of the TJ when the jet stream is weaker. By applying a new narrowing index, we demonstrate the need to improve topography details in the CMIP6 models, particularly those with resolution coarser than 1.5°, in order to properly simulate the TJ and the observed rainfall over the northwestern areas of eastern Africa.