Miracle-dz/UniFAR-FTUs huggingface dataset:
Stark Parameter Regularities of Multiply Charged Ion Spectral Lines Originating from the Same Transition Array

Published data concerning Stark widths for spectral lines originating from 3s-3p transition arrays of multiply charged ions of different elements are used to demonstrate their dependence on the upper level ionization potential and the rest core charge of the emitter seeing by the electron undergoing transition. The relations found for particular electron temperatures and densities have been used to predict Stark widths of the following highly striped ions where not yet available: Mg VII, Mg IX, Mg X, Na VII, Na VIII, Al VIII, Al X, Al XI, Si XI, Ti XI, Cr XIII, Cr XIV, Fe XV, Fe XVI, Fe XXIII, and Ni XVIII. The accuracy of the data obtained is comparable to the accuracy of the experimental and theoretical values used in establishing these dependences.
Resistin Promotes Nasopharyngeal Carcinoma Metastasis through TLR4-Mediated Activation of p38 MAPK/NF-κB Signaling Pathway

Simple Summary Chronic inflammation is associated with the development of nasopharyngeal carcinoma (NPC). Mounting evidence has indicated that resistin is an inflammatory cytokine that is associated with the risk of tumorigenesis. However, the correlation between serum resistin levels and the risk of NPC remains unclear. Here, we found that high serum resistin levels in NPC patients were positively correlated with lymph node metastasis and that resistin promoted the metastasis of NPC cells both in vitro and in vivo. Furthermore, we elucidated the underlying molecular mechanisms through which resistin promotes metastasis in NPC cells by inducing the epithelial-mesenchymal transition (EMT). Abstract NPC is a type of malignant tumor with a high risk of local invasion and early distant metastasis. Resistin is an inflammatory cytokine that is predominantly produced from the immunocytes in humans. Accumulating evidence has suggested a clinical association of circulating resistin with the risk of tumorigenesis and a relationship between blood resistin levels and the risk of cancer metastasis. In this study, we explored the blood levels and the role of resistin in NPC. High resistin levels in NPC patients were positively associated with lymph node metastasis, and resistin promoted the migration and invasion of NPC cells in vitro. These findings were also replicated in a mouse model of NPC tumor metastasis. We identified TLR4 as a functional receptor in mediating the pro-migratory effects of resistin in NPC cells. Furthermore, p38 MAPK and NF-κB were intracellular effectors that mediated resistin-induced EMT. Taken together, our results suggest that resistin promotes NPC metastasis by activating the TLR4/p38 MAPK/NF-κB signaling pathways.
Interior estimates for Ritz-Galerkin methods

Interior a priori error estimates in Sobolev norms are derived from interior RitzGalerkin equations which are common to a class of methods used in approximating solutions of second order elliptic boundary value problems. The estimates are valid for a large class of piecewise polynomial subspaces used in practice, which are defined on both uniform and nonuniform meshes. It is shown that the error in an interior domain 2 can be estimated with the best order of accuracy that is possible locally for the subspaces used plus the error in a weaker norm over a slightly larger domain which measures the effects from outside of the domain Q. Additional results are given in the case when the subspaces are defined on a uniform mesh. Applications to specific boundary value problems are given. 0. Introduction. There are presently many methods which are available for computing approximate solutions of elliptic boundary value problems which may be classified as Ritz-Galerkin type methods. Many of these methods differ from each other in some respects (for example, in how they treat the boundary conditions) but have much in common in that they have what may be called "interior Ritz-Galerkin equations" which are the same. Here we shall be concerned with finding interior estimates for the rate of convergence for such a class of methods which are consequences of these interior equations. Let us briefly describe, in a special case, the type of question we wish to consider. Let &2 be a bounded domain in RN with boundary M2 and consider, for simplicity, the problem of finding an approximate solution of a boundary value problem (0.1) \u =f in Q2, (0.2) Au= g on U2, where A is some boundary operator. Suppose now that we are given a one-parameter family of finite-dimensional subspaces Sh (0 < h < 1) of an appropriate Hilbert space in which u lies and that, for each h, we have computed an approximate solution Uh c Sh to u using some Ritz-Galerkin type method. Here we have in mind, for example, methods such as the "engineer's" finite element method [8], [22], the Aubin-Babuska penalty method [2], [4], the methods of Nitsche [12], [13] or the Received October 15, 1973. AMS (MOS) subject classifications (1970). Primary 65N30, 65N15. Copyright i 1974, American Mathematical Society
The multiclass GI/PH/N queue in the Halfin-Whitt regime

We consider a multiserver queue in the heavy-traffic regime introduced and studied by Halfin and Whitt who investigated the case of a single customer class with exponentially distributed service times. Our purpose is to extend their analysis to a system with multiple customer classes, priorities, and phase-type service distributions. We prove a weak convergence limit theorem showing that a properly defined and normalized queue length process converges to a particular K-dimensional diffusion process, where K is the number of phases in the service time distribution. We also show that a properly normalized waiting time process converges to a simple functional of the limit diffusion for the queue length.
Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia

Although the overall survival rate of B cell acute lymphoblastic leukemia (B-ALL) in childhood is more than 80%, it is merely 30% in refractory/relapsed and adult patients with B-ALL. This demonstrates a need for improved therapy targeting this subgroup of B-ALL. Here, we show that the ten-eleven translocation 1 (TET1) protein, a dioxygenase involved in DNA demethylation, is overexpressed and plays a crucial oncogenic role independent of its catalytic activity in B-ALL. Consistent with its oncogenic role in B-ALL, overexpression of TET1 alone in normal precursor B cells is sufficient to transform the cells and cause B-ALL in mice within 3 to 4 months. We found that TET1 protein is stabilized and overexpressed because of its phosphorylation mediated by protein kinase C epsilon (PRKCE) and ATM serine/threonine kinase (ATM), which are also overexpressed in B-ALL. Mechanistically, TET1 recruits STAT5B to the promoters of CD72 and JCHAIN and promotes their transcription, which in turn promotes B-ALL development. Destabilization of TET1 protein by treatment with PKC or ATM inhibitors (staurosporine or AZD0156; both tested in clinical trials), or by pharmacological targeting of STAT5B, greatly decreases B-ALL cell viability and inhibits B-ALL progression in vitro and in vivo. The combination of AZD0156 with staurosporine or vincristine exhibits a synergistic effect on inhibition of refractory/relapsed B-ALL cell survival and leukemia progression in PDX models. Collectively, our study reveals an oncogenic role of the phosphorylated TET1 protein in B-ALL independent of its catalytic activity and highlights the therapeutic potential of targeting TET1 signaling for the treatment of refractory/relapsed B-ALL. Description TET1 promotes the initiation and progression of precursor B cell malignancies independent of catalytic activity and serves as a therapeutic target. Cutting B-ALL off à la TET1 The survival rate for patients with B cell lymphoblastic leukemia (B-ALL) is quite low in refractory or relapsed pediatric and adult patients. Ten-eleven translocation 1 (TET1) is often overexpressed in this cancer and represents a potential target. Here, Chen et al. saw that overexpression of TET1 was sufficient to transform normal precursor B cells. In addition, the authors targeted ATM or PKC, protein kinases that stabilize TET1, which inhibited B-ALL progression in vivo and when combined with vincristine improved survival in PDX models. The authors demonstrated TET1 as a key regulator of B-ALL and a potential target for treatment that requires further exploration. —DH
Switchable Nanozyme Activity of Porphyrins Intercalated in Layered Gadolinium Hydroxide

In this study, organo-inorganic nanohybrids LHGd-MTSPP with enzyme-like activity were prepared by in situ intercalation of anionic 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin and its complexes with Zn(II) and Pd(II) (MTSPP, M = 2H, Zn(II) and Pd(II)) into gadolinium layered hydroxide (LHGd). The combination of powder XRD, CHNS analysis, FT-IR, EDX, and TG confirmed the layered structure of the reaction products. The basal interplanar distances in LHGd-MTSPP samples were 22.3–22.6 Å, corresponding to the size of an intercalated tetrapyrrole molecule. According to SEM data, LHGd-MTSPP hybrids consisted of individual lamellar nanoparticles 20–50 nm in thickness. The enzyme-like activity of individual constituents, LHGd-Cl and sulfoporphyrins TSPP, ZnTSPP and PdTSPP, and hybrid LHGd-MTSPP materials, was studied by chemiluminescence analysis using the ABAP/luminol system in phosphate buffer solution. All the individual porphyrins exhibited dose-dependent antioxidant properties with respect to alkylperoxyl radicals at pH 7.4. The intercalation of free base TSPP porphyrin into the LHGd preserved the radical scavenging properties of the product. Conversely, in LHGd-MTSPP samples containing Zn(II) and Pd(II) complexes, the antioxidant properties of the porphyrins changed to dose-dependent prooxidant activity. Thus, an efficient approach to the design and synthesis of advanced LHGd-MTSPP materials with switchable enzyme-like activity was developed.
Existence of Equilibrium in Bayesian Games with Infinitely Many Players

Abstract We prove the existence of a Bayesian Nash equilibrium for a Bayesian game with infinitely many players. We make three main advances to the existing literature. In particular: 1. We provide existence theorems where the set of agents can be any infinite set (countable or uncountable) as well as a measure space. 2. We use the information partition approach to model the differential information rather than the type set approach and therefore, our equilibrium is in behavioral strategies rather than in distributional strategies. This enables us to dispense with the independent type assumption used by the others in the literature. 3. Our modeling allows the individual's action set to depend on the states of nature and to be an arbitrary subset of an infinite dimensional space. In order to incorporate all the above generalizations, we offer a new proof of a novel type.Journal of Economic LiteratureClassification Numbers: C72, C11.
SEISMIC RESPONSE OF PIPING SYSTEMS WITH ISOLATION DEVICES

In this paper, effectiveness of sliding friction damper is studied for reducing the seismic response of piping system. A 3D piping system with sliding friction damper as piping support is chosen for the present study. PiSA\NL – a computer program is developed by the authors to analyze large sized 3D piping systems equipped with friction dampers. Time history analysis of a model piping system with friction damper is carried out using the PiSA\NL program. Wen’s hysteretic model is used to represent the analytical force-deformation characteristics in the friction damper. A simplified method is also proposed for spectrum analysis of the piping system involving linearization of the hysteretic Wen’s Model. The results obtained analytically are compared with the experimental results and found to be comparable. It is found that the friction damper when used as piping support is very effective in reducing the seismic response of the piping system. Comparison of results also shows the analytical results are in close agreement with the experimental results of piping system with friction support.
A sinh transformation for evaluating two‐dimensional nearly singular boundary element integrals

A new transformation technique is introduced for evaluating the two‐dimensional nearly singular integrals, which arise in the solution of Laplace's equation in three dimensions, using the boundary element method, when the source point is very close to the element of integration. The integrals are evaluated using (in a product fashion) a transformation which has recently been used to evaluate one‐dimensional near singular integrals. This sinh transformation method automatically takes into account the position of the projection of the source point onto the element and also the distance b between the source point and the element. The method is straightforward to implement and, when it is compared with a number of existing techniques for evaluating two‐dimensional near singular integrals, it is found that the sinh method is superior to the existing methods considered, both for potential integrals across the full range of b values considered (00.01. For smaller values of b, the use of the L 1‐1/5 method is recommended for flux integrals. Copyright © 2006 John Wiley & Sons, Ltd.
Reducible Families of Curves with Ordinary Multiple Points on Surfaces in IP3 C

In Keilen (2003); (2004); (2005) we gave numerical conditions which ensure that an equisingular family is irreducible respectively T-smooth. Combining results from Greuel et al. (2001) and an idea from Chiantini and Ciliberto (1999) we give in the present article series of examples of families of irreducible curves on surfaces in with only ordinary multiple points which are reducible and where at least one component does not have the expected dimension. The examples show that for families of curves with ordinary multiple points the conditions for T-smoothness in Keilen (2004) have the right asymptotics.
Structure and superfluidity of 4He films on plated graphite

The results of an experimental study using torsional oscillators of the superfluidity of 4He films adsorbed on hydrogen plated graphite are reported. The evolution of superfluidity with the growth of the film shows considerable structure arising from the atomic layering of the film. There is evidence that the superfluidity of a single fluid layer is strongly suppressed, possibly due to the influence of the periodic potential arising from the underlying solid layer. The behavior of two fluid layers is quite distinct, but shows similarities to that of thicker films on heterogeneous substrates; we suggest that the usual theory of the superfluidity of two-dimensional 4He should be extended to account for superfluid onset temperatures in such a film.
Impact of Higher Spatial Resolution on Precipitation Properties Over Australia

Coarse resolution datasets often poorly capture precipitation properties. It is commonly expected that skill at the local level should increase by refining spatial resolution. Here, we examine the influence of spatial resolution on the accuracy of means and extremes in precipitation by comparing high‐resolution dynamically downscaled data against the driving lower‐resolution reanalysis. We show that the higher‐resolution data are less accurate than lower‐resolution data for both mean and extreme precipitation. The quantitative deterioration (increase in the domain averaged relative error) from coarse to high resolution varies typically between 1%–8% and 5%–30% for mean and extreme precipitation, respectively. We also find that the finer‐scale variability resolved only by the higher‐resolution system and successfully predicted by that system is of negligible magnitude compared to the overall error (less than 1%). We conclude that finer‐scale resolution by itself does not necessarily bring a meaningful improvement in local simulation accuracy.
Combining Data from Polymerase Chain Reaction DNA Typing Experiments: Applications to Sperm Typing Data

Abstract The polymerase chain reaction (PCR) is a procedure by which the DNA in a single cell can be made to replicate many times in a test tube. By amplifying the DNA from individual sperm cells and typing the results, estimates of male recombination fractions can be made, which are valuable for creating genetic maps and locating regions of unusually intense crossover activity on the human genome. Because PCR typing results are subject to random error, stochastic models must be constructed to obtain accurate results. In practice, to obtain enough information to accurately estimate small recombination fractions, it is necessary to combine data from several PCR experiments. Stochastic models in common use assume that PCR error rates are constant across experiments. We show by analysis of a dataset that PCR error rates can vary considerably from experiment to experiment, and that models that fail to take this heterogeneity into account can produce biased estimators. We present two new estimators and show wi.
Physical and Wind Properties of OB-Stars

Abstract In this review, the physical and wind properties of OB-stars are discussed, with particular emphasis on metallicity dependence and recent results from the flames survey of massive stars. We summarize the relation between spectral type and Teff, discuss the status quo of the “mass-discrepancy”, refer to the problem of “macro-turbulence” and comment on the distribution of rotational velocities. Observational constraints on the efficiency of rotational mixing are presented, and magnetic field measurements summarized. Wind properties are reviewed, and problems related to weak winds and wind-clumping highlighted.
Winds at the Mars 2020 Landing Site. 2. Wind Variability and Turbulence

Wind speeds measured by the Mars 2020 Perseverance rover in Jezero crater were fitted as a Weibull distribution. InSight wind data acquired in Elysium Planitia were also used to contextualize observations. Jezero winds were found to be much calmer on average than in previous landing sites, despite the intense aeolian activity observed. However, a great influence of turbulence and wave activity was observed in the wind speed variations, thus driving the probability of reaching the highest wind speeds at Jezero, instead of sustained winds driven by local, regional, or large‐scale circulation. The power spectral density of wind speed fluctuations follows a power‐law, whose slope deviates depending on the time of day from that predicted considering homogeneous and isotropic turbulence. Daytime wave activity is related to convection cells and smaller eddies in the boundary layer, advected over the crater. The signature of convection cells was also found during dust storm conditions, when prevailing winds were consistent with a tidal drive. Nighttime fluctuations were also intense, suggesting strong mechanical turbulence. Convective vortices were usually involved in rapid wind fluctuations and extreme winds, with variations peaking at 9.2 times the background winds. Transient high wind events by vortex‐passages, turbulence, and wave activity could be driving aeolian activity at Jezero. We report the detection of a strong dust cloud of 0.75–1.5 km in length passing over the rover. The observed aeolian activity had major implications for instrumentation, with the wind sensor suffering damage throughout the mission, probably due to flying debris advected by winds.
Proof mining and combinatorics : Program extraction for Ramsey's theorem for pairs

In this thesis we give a proof-theoretic account of the strength of Ramsey's theorem for pairs and related principles. We develop a method to extract programs from proofs using this theorem. Moreover, we consider the strength of different variants of the Bolzano-Weierstras principle. We show that Ramsey's theorem for pairs implies a variant of the Bolzano-Weierstras principle and, hence, show that our program extraction method is applicable to proofs using this principle. Also, we develop a method to extract programs from proofs that use non-principal ultrafilters and along with this we obtain a conservation result for the statement that a non-principal ultrafilter exists. This method is based on the techniques we developed for Ramsey's theorem for pairs.
A comparison between two different stratospheric ozone datasets of HALOE observations and ERA-40 reanalysis

The ERA-40 reanalysis ozone data sets provided by ECMWF are most widely used at present, in order to use the data more effectively and reasonably, a comparison analyses are done and the features are discussed between the ERA-40 reanalysis and Halogen Occultation Experiment (HALOE) Observations on Upper Atmosphere Research Satellite (UARS). The spatial and temporal variations of the differences between two ozone data are analyzed in detail. Signal-to-Noise Ratios are estimated firstly by HALOE observational ozone concentration in seasonal and interannual time-scales, respectively. The results indicate that there are significant seasonal and interannual variations in a large part of stratosphere. The comparison analysis suggests that seasonal variation in ozone from ERA-40 is similar to HALOE observations and interannual variation in ozone from ERA-40 is greatly weaker than that of HALOE observations in the tropical middle stratosphere, but is enhanced at low latitudes in the lower stratosphere.
Frequency of t(4;14) in Multiple Myeloma and Its Clinicopathological Correlation

Objective: To determine the frequency of t(4;14) in multiple myeloma in Pakistani population and study the clinicpathological correlation of this translocation in myeloma patients. Study Design: Cross sectional study. Place and Duration of Study: This study was conducted at Armed Forces Institute of Pathology from Jun 2017 to May 2018 using non probability convenience sampling technique. Methodology: A total of 53 newly diagnosed cases of multiple myeloma were included in the study. Patients were diagnosed as having multiple myeloma based on diagnostic criteria of international myeloma working group. Fish analysis was done for t (4; 14). Workup for end organ damage /myeloma defining events was done. Results: Out of 53 patients, 16 (30%) were females and 37(70%) were males; the mean age of the patients was 59.81 ± 11.34 range from 37 to 87 years. Fish for t(4;14) was positive in eight (15%) patients while negative in forty-five (85%) patients. Patients with positive results have significantly deranged renal function tests and raised beta 2 micoglobulins levels as compare to t(4;14)negative patients. Conclusions: Detection of t (4:14) in multiple myeloma patients not only has diagnostic value but is important in risk stratification of these patients and thus effect treatment decision.