Miracle-dz/UniFAR-FTUs huggingface dataset:
The stability of monoclonal antibodies.

The Stability of Monoclonal Antibodies Monoclonal antibodies (mAbs) are antibodies which are homogeneous and are of constant specificity and affinity. These properties make them ideal targets for rational drug design as molecular biology techniques allows the therapy to be genetically designed to fit the disease or condition, but, the inherent instability and aggregation propensity of such protein drugs poses serious problems for the pharmaceutical industry. With these problems in mind, the stability of mAbs in solution has been extensively studied using a range of biophysical techniques. With a view to correlating thermal unfolding data with protein drug shelf-life, differential scanning calorimetry (DSC) was used to study the thermal unfolding of three mAbs (Campath-IH, 4162W94 and 1209W95). It was found that each of the antibodies unfolds irreversibly and, by complementing DSC results with results from circular dichroism (CD) and intrinsic tryptophan fluorescence spectroscopy, we show all three mAbs unfold by firstly undergoing a small change in tertiary structure which is then followed by, at a higher temperature, major changes in both tertiary and secondary structure after which all structure is lost. Kinetic analysis of these irreversible processes over a range of pH and DSC scan rates resulted in the calculation of the activation energy (E a) and rate constants of unfolding. Extrapolation of these rate constants to physiological conditions afforded an estimate of drug shelf-life which we have shown is relevant only when thermal unfolding is the only reaction resulting in protein denaturation. The effect of various additives on the thermal unfolding of the antibodies has also been studied using both DSC and fluorescence spectroscopy, in particular fluorescence quenching techniques and the use of the extrinsic fluorescent probe ANS (8-anilino-l-naphthalene sulfonic acid). These studies revealed that mannitol exerts a strong stabilising influence i.e. increases the mean unfolding temperature (Tm) whereas cyclodextrins decrease the Tm and are therefore considered destabilising additives. Cyclodextrins also prevent gross thermal aggregation of the mAbs possibly as a result of binding to exposed hydrophobic amino acid residues and masking hydrophobic patches which are indicated in aggregate formation.
Liouville theorems for an integral equation of Choquard type

We establish sharp Liouville theorems for the integral equation \begin{document}$ u(x) = \int_{\mathbb{R}^n} \frac{u^{p-1}(y)}{|x-y|^{n-\alpha}} \int_{\mathbb{R}^n} \frac{u^p(z)}{|y-z|^{n-\beta}} dz dy, \quad x\in\mathbb{R}^n, $\end{document} where \begin{document}$ 0 and \begin{document}$ p>1 $\end{document} . Our results hold true for positive solutions under appropriate assumptions on \begin{document}$ p $\end{document} and integrability of the solutions. As a consequence, we derive a Liouville theorem for positive \begin{document}$ H^{\frac{\alpha}{2}}(\mathbb{R}^n) $\end{document} solutions of the higher fractional order Choquard type equation \begin{document}$ (-\Delta)^{\frac{\alpha}{2}} u = \left(\frac{1}{|x|^{n-\beta}} * u^p\right) u^{p-1} \quad\text{ in } \mathbb{R}^n. $\end{document}
Developments in Psychometric Population Models for Technology-Based Large-Scale Assessments: An Overview of Challenges and Opportunities

International large-scale assessments (ILSAs) transitioned from paper-based assessments to computer-based assessments (CBAs) facilitating the use of new item types and more effective data collection tools. This allows implementation of more complex test designs and to collect process and response time (RT) data. These new data types can be used to improve data quality and the accuracy of test scores obtained through latent regression (population) models. However, the move to a CBA also poses challenges for comparability and trend measurement, one of the major goals in ISLAs. We provide an overview of current methods used in ILSAs to examine and assure the comparability of data across different assessment modes and methods that improve the accuracy of test scores by making use of new data types provided by a CBA.
Stochastic functional estimates in longitudinal models with interval‐censored anchoring events

Timelines of longitudinal studies are often anchored by specific events. In the absence of the fully observed anchoring event times, the study timeline becomes undefined, and the traditional longitudinal analysis loses its temporal reference. In this paper, we considered an analytical situation where the anchoring events are interval censored. We demonstrated that by expressing the regression parameter estimators as stochastic functionals of a plug‐in estimate of the unknown anchoring event time distribution, the standard longitudinal models could be extended to accommodate the situation of less well‐defined timelines. We showed that for a broad class of longitudinal models, the functional parameter estimates are consistent and asymptotically normally distributed with a n convergence rate under mild regularity conditions. Applying the developed theory to linear mixed‐effects models, we further proposed a hybrid computational procedure that combines the strengths of the Fisher's scoring method and the expectation‐expectation (EM) algorithm for model parameter estimation. We conducted a simulation study to validate the asymptotic properties and to assess the finite sample performance of the proposed method. A real data example was used to illustrate the proposed method. The method fills in a gap in the existing longitudinal analysis methodology for data with less well‐defined timelines.
Antibiotic Prophylaxis for Open Fractures in the Emergency Department

Emergency departments across the country regularly treat patients with traumatic injuries. One of the more common injuries that these patients present with is open fractures. Much of the morbidity associated with these fractures can be traced to the development of fracture-site infections that can lead to chronic osteomyelitis, impaired bone healing, and potential limb loss. Initial wound cultures in this setting are frequently positive, but they tend to demonstrate poor correlation with subsequent infections. The emergent management of open fractures includes a multipronged approach that includes stabilization, debridement, irrigation, soft tissue coverage, and systemic empiric antibiotics for prophylaxis. This review will discuss the etiology and factors associated with the development of infections in this setting, the use of empiric antibiotics, and the guidelines currently available.
Razumikhin-type theorems on polynomial stability of hybrid stochastic systems with pantograph delay

The main aim of this paper is to investigate the polynomial stability of hybrid stochastic systems with pantograph delay (HSSwPD). By using the Razumikhin technique and Lyapunov functions, we establish several Razumikhin-type theorems on the \begin{document}$ p $\end{document} th moment polynomial stability and almost sure polynomial stability for HSSwPD. For linear HSSwPD, sufficient conditions for polynomial stability are presented.
Adjusted saturation flow of some signalized intersection in Semarang, Indonesia

Indonesian Highway Capacity Manual or IHCM (1997) is a manual used to analyse performance of Indonesia’s road network. It has been more than 20 years since the manual is firstly published, so that some parameters such as passenger car equivalent (pce) and base saturation flow (S0) are no longer in accordance with actual conditions, which is indicated by significant differences between IHCM analysis results and empirical data. Several studies have been conducted in many cities and rural areas across Indonesia to explore pce, base saturation flow or other adjustment factors, in order to update IHCM, so in general, this manual will be more appropriate for current traffic conditions. This study is aimed at obtaining adjusted saturation flow from three signalized intersections in Semarang City, based on a comparison between predicted queue lengths and the empirical ones. Using the vehicle departure time slice data for green time, the pce and saturation flow was adjusted using regression method. Adjusted saturation flow at the observed intersection can be simplified in equation S = 506.48 We + 1857.9. Addition of variables still needs to be considered to gain a more general equation.
EFFECTS OF STATIC MAGNETIC FIELD ON Escherichia coli MUTATION

The effects of a dipolar static magnetic field of strength 400, 800, 1200 and 1600 Gauss were prepared locally, on the ultra-structure of E. coli type 1 bacterium cells have been studied. Equal volumes of liquid culture media were exposed to the magnetic field for different periods, the three most effective periods, namely: 24 hrs, 48 hrs and 72 hrs were chosen for all our experimental studies. After API kit test of treated E. coli culture media as control group. Results indicated that exposure of the microorganisms to the demonstrated magnetic field caused pronounced changes in the Arginine dihydrolase (ADH), Citrate utilization (CIT) and Gelatinase (GEL) were observed on the cell growth. Besides, changes in the morphology of the E. coli colonies were observed after exposure period and subculture on MacConkey agar. Furthermore, the bacterial growth subculture tested for morphological and biological activity, the results suggested that a mutation occurred in bacterial cells.
JUMLAH KOLONI BAKTERI PADA TELAPAK TANGAN PERAWAT YANG CUCI TANGAN YANG MELAKUKAN TINDAKAN MEDIS MENGGUNAKAN HANDSCOON

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian asam jawa (Tamarindusindica L ) terhadap intensitas nyeri dismenorea primer pada remaja putri. Desain penelitian yangdigunakan pra eksperimen dengan rancangan onegroup pre test post test, jumlah populasi 45 siswidan sampel 42 siswi, teknik sampling yang digunakan total sampling, metode pengumpulan datadengan menggunakan lembar observasi. Hasil analisa data didapatkan nilai Z hitung lebih besar dariZ tabel (5,708>2,576), dan sig z lebih kecil daripada Ai (0,000<0,01) sehingga dapat disimpulkanbahwa H0 ditolak artinya ada pengaruh pemberian asam jawa (Tamarindus indica L ) terhadap intensitasnyeri dismenorea primer pada remaja putri.
A Discriminative Tensor Representation Model for Feature Extraction and Classification of Multispectral LiDAR Data

Multispectral light detection and ranging (MS-LiDAR) systems open the door to the possibility in the 3-D land cover classification at a finer scale using only point cloud data. This article proposes a model based on the tensor representation for multispectral point cloud classification. The proposed method combines the 3-D local spatial structure of each multispectral point by characterizing the point with a second-order tensor. The first mode of the tensor indicates the spatial location and spectral information of each point (i.e., the row of the second-order tensor) and the second mode denotes the neighborhood geometric and spectral structures (i.e., the column of the second-order tensor). Then we develop a novel tensor manifold discriminant embedding (TMDE) algorithm to extract the geometric–spectral features for multispectral point clouds classification. TMDE solves the mapping matrices of each mode by preserving the intraclass samples’ distribution further making it more compact and maximizing the distance of different classes. Finally, the support vector machine classifier with the extracted features as input is used to implement the classification of multispectral point clouds. Experiments are conducted on two real multispectral point cloud data sets. The experimental results demonstrate that the proposed method can achieve significant improvements in classification accuracies in comparison with several state-of-the-art algorithms.
Novel coated differentially fed dual‐band fractal antenna for implantable medical devices

A novel differentially fed fractal antenna coated with a layer of a dielectric film and operating at two bands of Medical Implant Communication Services 402-405MHz and Industrial, Scientific, and Medical 2.4-2.48GHz, is investigated to enable sufficient data transmission rates, while featuring a `mode-control' signal to prolong the battery life. The symmetrical fractal technology of Hilbert curve is employed to miniaturise the dimension. To facilitate interfacing with peripheral integrated circuits, differentially feeding is adopted. To demonstrate how common-mode noises are suppressed, for the first time, a detailed analysis about the noise suppression of the differential configuration with two feedings is presented. A layer of thin film is coated around the proposed antenna to isolate the effect of human tissues and alleviate the electromagnetic coupling with human body. Moreover, to draw a design methodological guideline, the key geometrical parameters are analysed numerically and theoretically. Health safety considerations, radiation performance, and link budgets are also discussed to validate the proposed antenna's applicability in biomedical telemetry.
Öğretmen Performansinin Göstergesi Olarak Merkezi Sinavlar ve Eğitimde Performans Değerlendirme 1 Standardized Examinations as a Teacher Performance Indicator and Performance Evaluation in Education

This paper aims to analyze how standardized examinations function as a teacher performance indicator and the performance evaluation system in education through the teachers' opinions. For this aim, qualitative research approach was used and in-depth interviews were conducted with twenty-one teachers using a semi-structured interview. Teachers' opinions can be classified around two main themes: The first of these is the function of standardized exams as a performance indicator and the other is about the performance evaluation system in education. According to this research, standardized exams in education result in the classification of schools and teachers based on the exam results functioning as a performance indicator. A large part of teachers mentioned that they didn't support the performance evaluation system and this system would undermine the solidarity between teachers and create loss of rights. Theteachersthatsupporttheperformanceevaluationsystemwiththerhetoric of "separating working and non-
Modeling Temperature-Dependent Avalanche Characteristics of InP

Avalanche photodiodes (APDs), and single photon avalanche diodes (SPADs), with InP avalanche regions and InGaAs absorption regions, are used for detecting weak infrared light at ∼1.55 μm wavelength. These devices are often cooled to below room temperature during operation yet both validated simulation models and impact ionization coefficients that accurately describe the avalanche characteristics of InP are lacking in the temperature range of interest (200 K to room temperature). In this article we present an accessible, validated temperature dependent simulation model for InP APDs/SPADs. The model is capable of simulating avalanche gain, excess noise, breakdown voltage, and impulse current at 150–300 K. Temperature dependent ionization coefficients in InP, which may be used with other APD/SPAD simulation models, are also presented. The data reported in this article is available from the ORDA digital repository (DOI: 10.15131/shef.data.c.4373006).
Model-Based Feedback Control of Live Zebrafish Behavior via Interaction With a Robotic Replica

The possibility of regulating the behavior of live animals using biologically-inspired robots has attracted the interest of biologists and engineers for over 25 years. From early work on insects to recent endeavors on mammals, we have witnessed fascinating applications that have pushed forward our understanding of animal behavior along new directions. Despite significant progress, most of the research has focused on open-loop control systems, in which robots execute predetermined actions, independent of the animal behavior. In this article, we integrate mathematical modeling of social behavior toward the design of realistic feedback laws for robots to interact with a live animal. In particular, we leverage recent advancements in data-driven modeling of zebrafish behavior. Ultimately, we establish a novel robotic platform that allows real-time actuation of a biologically-inspired three-dimensionally printed zebrafish replica to implement model-based control of animal behavior. We demonstrate our approach through a series of experiments, designed to elucidate the appraisal of the replica by live subjects with respect to conspecifics and to quantify the biological value of closed-loop control.
Star formation in dwarf galaxies in the ELAIS N1 field

Abstract We estimated several parameters of dwarf galaxies, including their star formation rate and dust mass, and compared them with galaxies with larger stellar masses. We have chosen dwarf galaxies in the ELAIS N1 field, and fitted their Spectral Energy Distributions (SED). We used data from the new Herschel SPIRE and PACS Point Source catalogues to constrain the infrared radiation. Data available in VIZIER from multiple surveys have also been used. We determined that the star formation rate (SFR), M* and Mdust is one order of magnitude lower in dwarf galaxies compared to galaxies with larger stellar masses. However, the starburtiness was higher in the dwarf galaxies. They also had lower redshifts than normal galaxies, so we compared them to a subsample of normal galaxies with lower redshifts. The dust masses and SFRs of the dwarf galaxies were slightly lower, but their starburtiness was higher.
First Report of Wound Infection with Bacillus pumilus in Iran

Aims: Bacillus pumilus is a spore-forming bacillus that causes infections which has been rarely reported among humans. This research was the first report of isolating B. pumilus from bed sore in a patient who was a rancher in Iran. Presentation of Case: In October 2012 a man with an injured livestock in the back area with fever, pain, bleeding, inflammation, accompanied by black necrosis tissue was hospitalized. According to the patient statements ulcer was due to contamination by animal. After the wound biopsy, the infectious specimen was cultured on the blood agar culture medium and then several biochemical tests were performed in order to identify. Polymerase chain reaction (PCR) was used for determining molecular identity. Discussion and Conclusion: PCR was used for molecular identification. Result of sequencing and blast showed 99% homology with B. pumilus According to physician orders, patient was treated with clindamycin and ceftriaxone. Results of the present research showed that Bacillus B. pumilus in addition to the gastrointestinal and skin infections in humans can be a factor in bed sore disease. Case Study Annual Research & Review in Biology, 4(21): 3220-3226, 2014 3221 Keyword: Bacillus pumilus; PCR; bedsore; wound Infection.
HYPERBOLIC CONSENSUS GAMES∗

We introduce the use of conservation laws in multi-player consensus games. Indeed, a general non-anticipative strategy is proposed within a rigorous analytic framework. By means of numerical integrations, we describe peculiar features of this strategy, such as its eﬀectiveness, the automatic formation of coalitions and the eﬀects of competitions.
UAV for monitoring the settlement of a landfill

ABSTRACT Remote-pilot aircraft are developing very rapidly and their potential in the various fields is often still to be fully investigated. The possibility to fly over the areas to be surveyed without the need to access the areas themselves makes the use of UAVs in some cases certainly preferable for safety reasons, as has already been tested for the management of post-disaster areas. Waste landfills are small sites where contact with waste itself must be limited and scientific experimentation on surveying this specific type of site is currently limited. The results obtained in other types of sites or infrastructures are not automatically applied to waste landfills due to the specific geometrical characteristics and texture of the images that can be obtained at sites like these. In this work, a test on an exhausted landfill has been carried out with attention to the accurate survey of a large number of control points necessary for a correct assessment of the final geometric accuracy. The use of ground control points and checkpoints has allowed the separate evaluation of precision and accuracy, which are very close to those obtained with the most common methods for these sites, such as laser scanning and total stations.
The merger debris of dwarf galaxies in the local stellar halo

Abstract Based on the second Gaia data release and spectroscopy from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) Data, we identified 23,582 halo stars kinematically. The halo streams in the solar neighborhood could be detected in the space of energy and angular momentum. We reshuffle the velocities of these stars to determine the significance of the substructure. Finally, we find 14 statistically significant substructures and several substructures are not reported by previous works. These structures may be the debris of dwarf galaxies accretion event and their dynamical and chemical information can help to understand the history of the Galaxy.
Microbacterium resistens Prosthetic Joint Infection: A Case Report Due to a Vancomycin-Resistant Coryneform and Brief Literature Review of Infections Due to the Genus

AbstractCoryneforms are ubiquitous bacteria that encompass a broad spectrum of genera with similar microscopic morphology. Although the worldwide incidence of diphtheria is on the decline as a result of immunization, nondiphtheria coryneform infections due to Corynebacterium jeikeium, Actinomyces israelii, Rhodococcus equi, and Propionibacterium acnes are on the rise, particularly among those who are predisposed as a consequence of an immunocompromised state and bioprosthetic material. Taxonomical changes over time have led to some misclassification of cases. However, I report the first case of prosthetic joint infection due to a vancomycin resistant coryneform, Microbacterium resistens, and a literature review of the 32 conglomerate cases of Microbacterium species infection reported to date. Clinicians and microbiology laboratory personnel should have heightened awareness that such organisms should not be automatically deemed skin contaminants, as in the proper clinical context they may represent true pathogens.
An overview of common procedures for the management of tinnitus patients

management procedures most frequently used by non-physician hearing healthcare providers (HHPs). Subjective tinnitus is a symptom associated with practically every known otologic disorder. Evidence suggests that when there is a peripheral attenuation of acoustic stimulation (as would be caused by hearing loss) there is also an increase in central auditory nervous system activity at numerous anatomical sites, including the dorsal cochlear nucleus, inferior colliculus, and auditory cortex.1,2 This has been verified via neuroimaging.3 Further support for a central model of tinnitus is that patients whose symptoms are presumably caused by cochlear damage from noise exposure may still “hear” tinnitus following the surgical destruction of the auditory nerve.