Miracle-dz/UniFAR-FTUs huggingface dataset:
Contextual specificity in classroom adjustment: Latent profiles of primary school behavior problems in Trinidad and Tobago

ABSTRACT Behavioral problems are commonly observed in primary school children, yet the educational contexts in which children’s behaviors occur vary across regions of the world. Thus, culturally adapted and context-specific behavioral assessments are needed to successfully identify and support children at risk for severe behavior problems. This study examines behavior problems in a nationally representative sample (N = 700) of primary school students in Trinidad and Tobago using the Adjustment Scales for Children and Adolescents, a contextually-based assessment that has been adapted and standardized for use with this population. We applied latent profile analysis, a person-centered approach, to identify distinct patterns of behavior problems and contexts in which behaviors occurred. The resultant 6-profile model consisted of two profiles of adjusted children making up 60% of the sample and four profiles of at-risk children with elevated underactive and/or overactive behavior problems associated with different classroom contexts. Profiles were differentially associated with classroom learning behaviors and reading ability. The most vulnerable subgroup of primary school students showed high levels of under- and overactive behaviors in peer, learning, and teacher contexts, deficits in reading fluency, problem-solving, and motivation.
Anticipated emotions of significant others as social influence: Can they predict students’ smoking abstinence continuance intention?

In the Theory of Planned Behavior (Ajzen, 1991), subjective norms (SN) represent social influence on an individual's behavior. This famous model of behavior postulates that an individual is under pressure or expectation of significant others to perform or not to perform a behavior. This study starts from the premise that an individual can take the initiative and regulate his or her behavior to generate anticipated emotion of significant others’ (AESO). The question is, can the AESO function as the SN to represent the social factor in influencing students' smoking abstinence continuance intention? To answer this question, the author conducts the study upon 235 non-smoker students. The result is; first, negative AESO can carry out that function. However, positive AESO and SN fail to do so. Therefore, besides the SN, as shown by this study, the AESO, represented by negative AESO, can be regarded as a social influence component of an individual's behavioral intention. Other researchers are encouraged to validate this finding in different contexts of behavior.
One Size Does Not Fit All: The Past, Present and Future of Cystic Fibrosis Causal Therapies

Cystic fibrosis (CF) is the most common monogenic disorder, caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Over the last 30 years, tremendous progress has been made in understanding the molecular basis of CF and the development of treatments that target the underlying defects in CF. Currently, a highly effective CFTR modulator treatment (Kalydeco™/Trikafta™) is available for 90% of people with CF. In this review, we will give an extensive overview of past and ongoing efforts in the development of therapies targeting the molecular defects in CF. We will discuss strategies targeting the CFTR protein (i.e., CFTR modulators such as correctors and potentiators), its cellular environment (i.e., proteostasis modulation, stabilization at the plasma membrane), the CFTR mRNA (i.e., amplifiers, nonsense mediated mRNA decay suppressors, translational readthrough inducing drugs) or the CFTR gene (gene therapies). Finally, we will focus on how these efforts can be applied to the 15% of people with CF for whom no causal therapy is available yet.
Balanced Organizational Controls and Financial Sustainability of Faith-based Organizations

Maintaining financial sustainability over the long term is vital for faith-based organizations since many of them offer services to very needy communities. However, faith-based organizations, particularly in Africa, struggle to sustain the financial resources required to effectively realize their mission. This study sought to establish the degree to which organizational controls affect the financial sustainability of faith-based organizations affiliated to Wycliffe Global Alliance in Africa. This study was anchored on strategic leadership and agency theory and was based on the positivism research paradigm. The study adopted descriptive research design and used primary data collected from 198 leaders serving as directors, heads of departments, and heads of units in faith-based organizations affiliated with Wycliffe Global Alliance in Africa. Descriptive statistics reported means and standard deviations respectively for the independent variables as follows; monitoring controls 3.71 and 0.480, premise controls 3.80 and 0.629, special alert controls 3.79 and 0.647, implementation controls 4.12 and 0.587, and for financial sustainability as the dependent variable 4.33 and 0.753. Multiple linear regression analyses results indicated that the financial sustainability of faith-based organizations affiliated to Wycliffe Global Alliance was highly predicted by balanced organizational controls with the independent variables explaining 38.8 percent of financial sustainability variation. The study concluded that balanced organizational controls if fully utilized and supported could enhance the financial sustainability of faith-based organizations. The study recommends that leaders of faith-based organizations should provide a favourable environment for balanced organizational controls to be effectively practiced in order to strengthen financial sustainability.
Complement Activation Profile in Myasthenia Gravis Patients: Perspectives for Tailoring Anti-Complement Therapy

The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs. Here, we searched for plasma complement proteins as indicators of complement activation status in AChR-MG patients, and potential biomarkers for tailoring anti-complement therapy in MG. Plasma was collected from AChR-MG and MuSK-MG patients, and healthy controls. Multiplex immunoassays and ELISA were used to quantify a panel of complement components (C1Q, C2, C3, C4, C5, Factor B, Factor H, MBL, and properdin) and activation products (C4b, C3b, C5a, and C5b-9), of classical, alternative and lectin pathways. C2 and C5 levels were significantly reduced, and C3, C3b, and C5a increased, in plasma of AChR-MG, but not MuSK-MG, patients compared to controls. This protein profile was indicative of complement activation. We obtained sensitivity and specificity performance results suggesting plasma C2, C3, C3b, and C5 as biomarkers for AChR-MG. Our findings reveal a plasma complement “C2, C3, C5, C3b, and C5a” profile associated with AChR-MG to be further investigated as a biomarker of complement activation status in AChR-MG patients, opening new perspectives for tailoring of anti-complement therapies to improve the disease treatment.
Single-Cell RNA-Sequencing Reveals the Cellular and Genetic Heterogeneity of Skin Scar to Verify the Therapeutic Effects and Mechanism of Action of Dispel-Scar Ointment in Hypertrophic Scar Inhibition

Hypertrophic scarring (HS), caused by excessive fibrosis of injured skin, imposes a psychological burden and creates a source of distress that impairs the quality of life of affected individuals. However, the gold standard for HS treatment has not yet been determined due to the complicated and difficult nature of the routines and procedures involved. Previous studies have indicated that the topical application of certain active components found in traditional Chinese medicines shows potential as a therapeutic alternative for scars. Here, single-cell RNA-sequencing was performed to determine cellular heterogeneity and identify marker genes and mechanisms associated with HS. It was found that fibroblasts comprise the largest proportion of HS cell types. The marker genes that were highly expressed in fibroblasts were extracellular matrix (ECM)-related, whereas ECM-receptor interactions and the transforming growth factor (TGF)-β signalling pathway were also found to be active. Ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, which was applied to identify the molecular compounds of Dispel-Scar Ointment (DSO), revealed 74 effective chemical components belonging to 14 types of constituents, such as flavonoids, tanshinones, salvianolic acids, glycosides, and phthalides. Furthermore, in vivo studies using rat scar models showed that the topical application of Salvia miltiorrhiza, Ligusticum chuanxiong, peach kernel, safflower, and motherwort exerted beneficial effects on fibroblasts. DSO promoted scar maturation and reduced scar areas, its efficacy being similar to that of topically applied silicone. Functional studies using immunofluorescence staining, western blotting, and quantitative real-time polymerase chain reaction demonstrated that DSO may target the TGF-β/Smad pathway to inhibit collagen synthesis and promote ECM remodelling. However, further in vitro mechanistic research and single-drug prescription studies may be required to identify the specific effective compound or active ingredient of DSO, which would provide more substantial evidence regarding the potential therapeutic value of traditional herbs in HS.
Sleep Disorders in General Hospital: A Cross-Sectional Study in 253 Patients Hospitalized In Different Medical and Surgical Services

Introduction: Sleep is a fundamental physiological need. It is important to understand the prevalence of sleep disorders, especially in patients with a somatic disease. Method: The study had as scope patients admitted to the medical and surgical services of general hospital, during a period of one month. The approach used in this study is a qualitative approach, based on a semi-structured, concise, and clear questionnaire. Results: The main aim of this study was to estimate the frequency of sleep disorders and their management by somantician doctors in the Moulay Ismail military hospital. This present study has 2 important results; the first one, sleep disorders are common in patients with somatic pathology. The second one, and against the recognition and management of these disorders by health professionals is rare. Conclusion: It is essential to alert both public and health practitioners to this subject through public education campaigns creating awareness of the consequences of sleep disorders but also through adequate training of physicians for a better screening and treatments of insomnia problems.
Effect of a short hot water treatment on thermal tolerance of Queensland fruit fly, 'Bactrocera tryoni' (Froggatt) infesting 'Capsicum annuum' cultivars

Capsicums and chillies ('Capsicum annuum') grown on Australia's east coast are vulnerable to infestation by Queensland fruit fly (Bactrocera tryoni Froggatt) (Qfly). The fruit must be treated to ensure it is free of this pest before transport to fruit fly free markets interstate and internationally. Cold storage offers a relatively cheap and easily applied disinfestation option, but has not been recommended for 'C. annuum' cultivars because the fruit is chilling sensitive. Recently it has been shown that a short hot water shower (HWS) can reduce chilling sensitivity, allowing fruit to be stored at 3 degreesC. In this trial we examined whether a 60 second shower under 55 degreesC water affected mortality of Qfly eggs and larvae in 'C. annuum' cultivars stored at 3 degreesC. Differences between the lifestages were observed, with 1st instar larvae being the most cold tolerant overall. The HWS alone caused significant mortality to all lifestages, the most mature larvae proving most susceptible. Treatment significantly reduced the time at 3 degreeC required to induce 90% mortality in 1st, 2nd and 3rd instar larvae although eggs were less affected. No eggs or larvae survived more than 7 days at 3 degreesC, regardless of treatment or variety. It is proposed that storing capsicums and chillies for 10 days at 3 degreesC can provide a high level of quarantine security against Qfly, irrespective of whether the fruit is first subjected to a HWS treatment.
A Review of Neural Network-Based Emulation of Guitar Amplifiers

Vacuum tube amplifiers present sonic characteristics frequently coveted by musicians, that are often due to the distinct nonlinearities of their circuits, and accurately modelling such effects can be a challenging task. A recent rise in machine learning methods has lead to the ubiquity of neural networks in all fields of study including virtual analog modelling. This has lead to the appearance of a variety of architectures tailored to this task. This article aims to provide an overview of the current state of the research in neural emulation of analog distortion circuits by first presenting preceding methods in the field and then focusing on a complete review of the deep learning landscape that has appeared in recent years, detailing each subclass of available architectures. This is done in order to bring to light future possible avenues of work in this field.
Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches

ABSTRACT Niosomes are multilamellar vesicles that efficiently deliver active substance into skin systemic circulation or skin layers. They are used in topical drug delivery system to enhance the skin permeation of active substance. So, the prime objective of this study was to develop a niosomal gel of fusidic acid to increase its skin permeation. Different formulations of niosomes of fusidic acid were designed by varying the cholesterol to surfactant ratio. Formulations containing fusidic acid, cholesterol, dihexadecyl pyridinium chloride, Span 60, or Tween 60 were prepared by thin film hydration method in rotary evaporator. The thin film formed in rotary flask was hydrated by phosphate buffer saline of pH 7.2. The niosomes formed were characterized through entrapment efficiency, size, polydispersity index (PDI), and zeta potential. The S3 formulation containing span 60 showed the highest entrapment efficiency (EE) of niosomes, so it was incorporated into Carbopol gel. Determination of pH, spreadability, rheological, and ex vivo permeation studies was conducted of niosomal gel. The results of ex vivo permeation studies showed high permeation of fusidic acid when gel was applied to an albino rat skin. According to the results and previous studies of niosomes, it can be concluded that niosomes enhanced the permeation of fusidic acid through the skin.
Factors Impact on Stocks Repurchase of Enterprises Listed on the Stock Market of Vietnam Period of 2015-2019

The report assessed the stock repurchase activities of companies listed on the Vietnamese stock market in 2015 - 2019. The article uses Tobit's regression model and FEM - Fixed Effect Model regression model. To determine the motivation of the business to buy back, build a model based on the existing models to evaluate the impact of the share buyback on the enterprise's business performance. The research results show that the sharing repurchase by enterprises lowers valuation or reduces the cost of free cash flow and capital structure of the enterprise. It will determine the repurchase of shares of that enterprise; Along with that, the company's stock repurchase will pay fewer dividends. With the impact of stock repurchases on the enterprise's business performance, the results show that stock repurchases have potential implications for future earnings and the profitability ratios on the business books.
Supplementary Index Bit Aided Transmit Diversity Scheme for Enhanced DCT-OFDM With Index Modulation

In this letter, a novel supplementary index bit aided transmit diversity (SIB-TD) approach is proposed for an enhanced discrete cosine transform based orthogonal frequency division multiplexing with index modulation (EDCT-OFDM-IM) system. Specifically, conventional index modulation (IM) is employed for the first antenna, i.e., the main branch, and the non-activated subcarriers’ indices in one index modulation group are utilized for the IM mapping on the same index modulation group for the second antenna, i.e., the diversity branch. Hence, each subcarrier can not be synchronously activated on the two antennas. Finally, the non-activated subcarriers of one antenna will transmit the same modulated symbols of the other antenna to exploit the diversity gain. At the receiver, a maximum likelihood group-wise receiver is also developed by detecting the main and diversity branches jointly. Simulation results demonstrate the superiority of the proposed scheme over both the conventional EDCT-OFDM-IM and the DFT-OFDM with Alamouti code either with or without IM respectively, even under the imperfect channel estimation.
Effects of annealing on SnS films produced by chemical bath deposition (CBD)

Tin sulfide (SnS) thin films were produced on glass substrates at 65 °C by chemical bath deposition (CBD). Two of the obtained five identical films were annealed in an air atmosphere while the other two were annealed in a nitrogen atmosphere at different temperatures. The effects of annealing (at 150 °C and 250 °C in air and nitrogen atmospheres) on the optical, structural, and electrical properties of the films were investigated by UV-visible spectrophotometer, x-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), and Hall-effect measurement. The energy band gap of as-deposited SnS thin film was determined to be 1.16 eV, and it was observed to change with annealing. All of the as-deposited and annealed SnS films had orthorhombic structures. The optical phonon modes to orthorhombic SnS phases were determined by Raman shifts. The carrier type of all SnS films was identified as p-type using Hall measurement, and the changing carrier concentration, mobility, and resistivity values of the films were investigated depending on annealing conditions. The p-type SnS film can be used as an alternative material for the absorber layer in p-n heterojunction solar cell applications.
Dynamics of the Middle Class in the Democratic Republic of Congo

The main objective of this study is to analyze the dynamics of the middle class in the DRC. It is based on a pseudo-panel corrected for statistical pitfalls from two waves of surveys on employment, the informal sector and household consumption, organized by the DRC's National Institute of Statistics in 2005 and 2012. From the analyzes carried out, it emerges that households identified as being part of the middle class were placed in the category known as the 'lower middle class'. In its evolution, the middle class has not undergone any significant expansion. Overall, this dynamic loses 2 percentage points and this is significantly observed in rural areas. In addition, a contrasting trend emerged at the level of the provinces. Only 11 provinces out of 26 have experienced significant growth in the middle class in 7 years. On the other hand, the dynamics of the middle class is not positive in 9 provinces, both in the lower middle class and in the upper middle class. The profiling carried out allows us to conclude that household characteristics such as the education of the head of household, the size of the household, its occupation status on the labor market and its socio-professional status have contributed to the dynamics of the middle class in the DRC.
Effects of Intramuscular Injections of Vitamins AD3E and C in Combination on Fertility, Immunity, and Proteomic and Transcriptomic Analyses of Dairy Cows during Early Gestation

This research aimed to investigate the effects of the intramuscular injection of vitamins AD3E and C in combination immediately before the estrus synchronization program (the Ovsynch program) on conception and pregnancy rates, blood parameters, serum biochemical properties, immune systems, antioxidant parameters, and proteomic and transcriptomic analyses during early gestation in dairy cows. Forty nonlactating multiparous cows were randomly assigned to one of four treatments: (1) C: control with normal saline injection; (2) VAD3E: a single intramuscular injection (I/M) of vitamin AD3E; (3) VAD3EC: injection of both vitamins AD3E and C; (4) VC: a single dose of vitamin C. Blood and serum samples were taken immediately at day 0 (before AI), day 7, and day 14 (after AI for 5 days) from the coccygeal vein. Generally, injections of AD3E and C in combination had no effect on the rate of conception or pregnancy. However, they improved hematological parameters and immune and antioxidant activities. Serum samples were analyzed using LC-MS/MS, and 8190 proteins were identified. Five proteins were successfully validated using the quantitative real-time reverse transcription PCR (qRT-PCR) method. This study found that lymphocyte-specific protein 1 (LSP1, A0A3Q1M894) could be used as a protein biomarker for cows administrated with vitamins AD3E and C.
Psychiatric Symptoms in Oncological Patients at Nuclear Medicine Department

Objective: In the process of PET/CT scanning, patients go through a general evaluation while their medical history is being taken, but it is often overlooked that these patients should be evaluated not only biologically but also bio psychosocially. Psychiatric symptom profiles and help-seeking behaviours of cancer patients were examined in this study. Methods: Cancer patients presented to nuclear medicine clinic filled out sociodemographic data form, psychiatric admission evaluation form, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI) and Symptom Checklist-90 (SCL-90) form for psychiatric symptom screening. Results: In this study 27.8% of the patients had a Beck Depression score ≥18 and were in the risk group for depression, 31.7% of the patients experienced moderate or severe anxiety symptoms. Beck Depression Total and Beck Anxiety Total values were found significantly higher in women than in men. Only 10,2% of the cancer patients reported that they sought psychiatric help in the last 6 months. Among the patients who were risky for depression according to BDI only 25% had been receiving psychiatric help and in among the patients who were risky for anxiety according to BAI only %26.9 had been receiving psychiatric help Conclusion: Nuclear Medicine physicians' interest in psychiatric symptoms and help-seeking behaviors of cancer patients referred to Nuclear Medicine Clinics is very important in terms of psycho-oncology.
The Throw Effectiveness in The Last Minutes of Handball Close Games and The Factors That Influence It

This paper examines the throw effectiveness in the last 10 minutes of close games (50-60th), during the season 2018-2019 of the Greek Men’s Handball Championship “Handball Premier”. The research observed all the matches from the 2018-2019 Greek Men’s Handball championship. 61% of the total attacks ended with a throw with 56% of them ending as a goal, while the rest 39% of the total attacks ended with a turnover or a 2- minute Suspension/Penalty. During the last ten minutes (50-60th), there was both an increase in the shots that came from the 6m area (22% to 26%) and the percentage of suspensions and penalties, while the percentage of the fast breaks declined by 4% (17% to 13%). In conclusion, whereas the total effectiveness of throws increased in the last 10 minutes (50-60th), the number of the fast breaks and the defensive effectiveness decreased resulting in more suspensions for the defensive team.