Miracle-dz/UniFAR-FTUs huggingface dataset:
Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) in Minimally Invasive Thoracic Surgery for Characterization of Pulmonary Tumours: A Clinical Feasibility Study

Simple Summary Finding solitary pulmonary nodules (SPNs) during thoracic surgery, especially during minimally invasive procedures, remains a major challenge. Moreover, in cases of unclear focal findings, the frozen section result must be waited for, which influences the surgical procedure. Therefore, we are investigating for the first time the use of intraoperative contrast-enhanced ultrasound (Io-CEUS) in minimally invasive thoracic surgery to, on the one hand, visualize unclear SPNs, and on the other hand, to characterize the SPNs directly before surgical resection. In the future, Io-CEUS could make “live histology” possible in thoracic surgery, which may influence the surgeon’s intraoperative decisions and the extent of lung resection. Abstract Background: The intraoperative detection of solitary pulmonary nodules (SPNs) continues to be a major challenge, especially in minimally invasive video-assisted thoracic surgery (VATS). The location, size, and intraoperative frozen section result of SPNs are decisive regarding the extent of lung resection. This feasibility study investigates the technical applicability of intraoperative contrast-enhanced ultrasonography (Io-CEUS) in minimally invasive thoracic surgery. Methods: In this prospective, monocentric clinical feasibility study, n = 30 patients who underwent Io-CEUS during elective minimally invasive lung resection for SPNs between October 2021 and February 2023. The primary endpoint was the technical feasibility of Io-CEUS during VATS. Secondary endpoints were defined as the detection and characterization of SPNs. Results: In all patients (female, n = 13; mean age, 63 ± 8.6 years) Io-CEUS could be performed without problems during VATS. All SPNs were detected by Io-CEUS (100%). SPNs had a mean size of 2.2 cm (0.5–4.5 cm) and a mean distance to the lung surface of 2.0 cm (0–6.4 cm). B-mode, colour-coded Doppler sonography, and contrast-enhanced ultrasound were used to characterize all tumours intraoperatively. Significant differences were found, especially in vascularization as well as in contrast agent behaviour, depending on the tumour entity. After successful lung resection, a pathologic examination confirmed the presence of lung carcinomas (n = 17), lung metastases (n = 10), and benign lung tumours (n = 3). Conclusions: The technical feasibility of Io-CEUS was confirmed in VATS before resection regarding the detection of suspicious SPNs. In particular, the use of Doppler sonography and contrast agent kinetics revealed intraoperative specific aspects depending on the tumour entity. Further studies on Io-CEUS and the application of an endoscopic probe for VATS will follow.
Relation between Lower Urinary Tract Dysfunction and Functional Outcome in Patients After Brain Tumor Resection

This study aimed to compare functional outcomes after rehabilitation with initial degree of urinary retention (UR) in patients operated on for brain tumors. Medical records of 61 patients transferred to the Department of Rehabilitation Medicine of single center, from January 2011 to December 2021, were reviewed retrospectively. Patient data included post-void residual (PVR) urine, tumor characteristics, and functional status. Functional status was evaluated on the Mini-Mental Status Examination (MMSE), Modified Barthel Index (MBI), Functional Ambulation Category (FAC), Modified Rankin Scale (mRS), Motricity Index (MI)-lower limb, and Berg Balance Scale (BBS). MMSE, FAC, mRS, and MI-lower limb were re-evaluated 3 weeks after standard inpatient rehabilitation. Twenty-four patients were in the UR group and 37 in the non-UR group. Initial MMSE, MBI, BBS, FAC, and mRS were significantly worse in the UR group, and both groups showed significant functional improvement after rehabilitation. After rehabilitation, MMSE, FAC, MRS, MI-lower were still worse in the UR group, but the degree of improvement between the groups was not significantly different. Rehabilitation was shown to be effective for brain tumor patients regardless of UR. Initial UR after brain tumor surgery is significantly associated with poor functional status in both the early stages of rehabilitation and after rehabilitation.
Animal-Assisted Education: Exploratory Research on the Positive Impact of Dogs on Behavioral and Emotional Outcomes of Elementary School Students

For some students, school success is not a simple matter. A growing, innovative approach that supports students’ functioning at school is programs in which animals are involved in education. The involvement of animals, especially dogs, in education is known as animal-assisted education (AAE). A literature review of AAE indicated a positive influence of AAE programs on the quality of learning and social emotional development in children. This study explored whether AAE positively impacts the social and emotional outcomes of elementary school students aged between 8 and 13 years through mixed methods. The methods used were a survey and an observational study. The survey section of the study showed that students participating in the program with the dogs rated themselves, after the intervention period, significantly higher in terms of self-confidence and had a more positive score for relationships with other students after the intervention. As rated by their teachers, after the intervention period, students scored significantly higher in relation to work attitude, pleasant behavior, emotional stability, and social behavior. In the observational study, we analyzed the video material of students who participated in an AAE program with dogs. We concluded that all verbal and non-verbal behaviors of the students increased, except eye contact. The current study indicates future directions for theoretical underpinnings, improved understanding, and the empirical measurement of the underlying variables and mechanisms.
Entrepreneurship, Skills for Santri to Become Job Creators

This study aims to determine fine practices in entrepreneurship for santri (Islamic boarding school students) based on personal characteristic factors (self-efficacy, locus of control, need for achievement, and adversity quotient) that exist in every human being. The research object is santri of the Manbaul Ulum Islamic Boarding School, South Kalimantan, which are generally limited in terms of curriculum content that equips them with productive skills as provisions of practices in society, becoming leaders in society, as well as role models in good economic and social religious activities. The progress of a nation is mainly determined by the advancement of entrepreneurship which is marked by the presence of a high entrepreneurial spirit of individuals so that they have rich initiative and develop creativity and innovation in seeing opportunities and opportunities around them. The Islamic boarding school curriculum generally contains religious education. Educational content that provides life skills in the economic field is very limited and even very limited. In reality, when they finish their education at Islamic boarding schools, students will face highly powerful economic activities that can even create jobs for the people around them. Through a quantitative descriptive research method on 71 students in Class XI and XII with multiple linear regression analysis, the results show that self-efficacy, locus of control, need for achievement, and adversity quotient partially have a significant effect on students’ entrepreneurial intentions. The most dominant influence in student entrepreneurship is the adversity quotient
Liquid Water from First Principles: Investigation of Different Sampling Approaches

A series of first principles molecular dynamics and Monte Carlo simulations were carried out for liquid water to investigate the reproducibility of different sampling approaches. These simulations include Car−Parrinello molecular dynamics simulations using the program cpmd with different values of the fictitious electron mass in the microcanonical and canonical ensembles, Born−Oppenheimer molecular dynamics using the programs cpmd and cp2k in the microcanonical ensemble, and Metropolis Monte Carlo using cp2k in the canonical ensemble. With the exception of one simulation for 128 water molecules, all other simulations were carried out for systems consisting of 64 molecules. Although the simulations yield somewhat fortuitous agreement in structural properties, analysis of other properties demonstrate that one should exercise caution when assuming the reproducibility of Car−Parrinello and Born−Oppenheimer molecular dynamics simulations for small system sizes in the microcanonical ensemble. In contrast, the m.
Association between the risk of hypertension and triglyceride glucose index in Chinese regions: a systematic review and dose-response meta-analysis of a regional update

Background Triglyceride-glucose (TyG) index has been reported to be associated with various cardiovascular diseases in recent years. However, the conclusive association between the TyG index and hypertension was not established in the last meta-analysis. Furthermore, it remains unclear whether a linear relationship exists between these two variables. Methods We conducted a comprehensive search of the CNKI, VIP, WanFang Data, CBM, PubMed, EMbase, Web of Science, and The Cochrane Library databases up until May 10, 2023, to identify relevant studies conducted in China. We used Stata version 17.0 and Rstudio version 4.2. 1 to analyze the data and assess the association between the TyG index and the risk of hypertension, as well as the dose-response relationship between these two variables. We will select either a random-effects model or a fixed-effects model based on the results of the heterogeneity tests and report 95% confidence intervals accordingly. Results In the end, our analysis encompassed 22 studies involving a total of 668,486 participants, comprising 12 cross-sectional studies and 10 cohort studies. Meta-analysis results showed: Analysis of data from China revealed that an elevated TyG index was associated with a higher risk of developing hypertension, as indicated by an OR/HR of 1.36 [95%CI (1.28–1.45) I2 = 69.0% P < 0.001]. Through meta-regression analysis of multiple covariates, we found that study type, study region, sample size, database source, and study quality score, the above five variables were able to explain 63.0% of the total heterogeneity. The results of the dose-response Meta-analysis showed: The TyG index has a linear relationship with the risk of developing hypertension, as indicated by non-significant coefficients of higher-order terms in the nonlinear model (P > 0.05). The linear trend analysis showed that for every one-unit increase in the TyG index, the risk of developing hypertension increased by 1.5 times [1.532 95%CI (1.294, 1.813) P < 0.001]. However, this result is influenced by the number of studies included in the dose-response analysis and requires further corroboration. Conclusion In the Chinese region, there was an independent association between TyG index and the risk of developing hypertension, with a linear trend. However, the results of the linear trend need to be corrected by the more number of related studies. Systematic Review Registration https://www.crd. york.ac. uk/prospero/display_record. php? ID=CRD42023425836.
X-Ray binaries in local analogs to the first galaxies

The focus of this dissertation is to investigate the effect of metallicity on high-mass Xray binary (HMXB) formation and evolution as a means to understand the evolution of the early Universe (z > 6). Understanding the population and X-ray output of HMXBs are vital to modelling the heating and ionization morphology of the intergalactic medium during the epoch of reionization. Current X-ray instruments are unable to directly detect very high redshift HMXBs, making it impossible to constrain population sizes in this way. Instead certain local galaxies may be used as analogs to infer the properties of galaxies in the early Universe. These local analogs should have properties consistent with those expected for the first galaxies, such as low-metallicity, compact morphology, and intense recent star
New Diagnostic and Prognostic Models for the Development of Alcoholic Cirrhosis Based on Genetic Predisposition and Alcohol History

Liver cirrhosis development is a multifactorial process resulting from a combination of environmental and genetic factors. The aim of the study was to develop accurate non-invasive diagnostic and prognostic models for alcoholic cirrhosis. Consecutive subjects with at-risk alcohol intake were retrospectively enrolled (110 cirrhotic patients and 411 non-cirrhotics). At enrollment, the data about lifetime drinking history were collected and all patients were tested for Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409, Transmembrane 6 Superfamily 2 (TM6SF2) rs58542926, and hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) rs72613567 variants. In cross-sectional analyses, models for the diagnosis of cirrhosis were developed using multivariate logistic regression. A predictive score for cirrhosis development over 24 years was built by evaluating time-dependent AUC curves. The best diagnostic accuracy was demonstrated by the model, which also includes daily alcohol consumption, duration of hazardous alcohol use, and genetic variants, with AUCs of 0.951 (95% CI 0.925–0.977) and 0.887 (95% CI 0.925–0.977) for cirrhosis and compensated cirrhosis, respectively. The predictive model for future cirrhosis development (AUC of 0.836 95% CI: 0.769–0.904) accounted for age at onset of at-risk alcohol consumption and the number of PNPLA3 and HSD17B13 variant alleles. We have developed accurate genetic and alcohol consumption models for the diagnosis of alcoholic cirrhosis and the prediction of its future risk.
STUDENT PERCEPTION AND PROMOTION MIX OF HOUSEKEEPING DEPARTMENT AT TRISAKTI TOURISM INSTITUTE

This study aims to determine the effect of student perceptions and promotion mix on the decision of Trisakti Tourism Institute students to choose the Housekeeping Department. This type of research is descriptive quantitative with multiple regression analysis methods. The population in this study were all students of the Trisakti Tourism Institute. While the sample in the study amounted to 133 respondents using the accidental sampling technique distributing questionnaires with a Likert scale of 1 to 5. Based on the results of the discussion above, it can be concluded that students' perceptions of the housekeeping departments are good with an average score of 3.73. This is of particular concern to the lecturers to maintain the quality of the teaching and learning process, especially so that students are more interested in working in the household world. Showing that advertising, personal selling, sales promotion, and public relations have a significant effect on the decision to choose a major in college
Correlation of CRISPR/Cas and Antimicrobial Resistance in Klebsiella pneumoniae Clinical Isolates Recovered from Patients in Egypt Compared to Global Strains

The CRISPR/Cas system has been long known to interfere with the acquisition of foreign genetic elements and was recommended as a tool for fighting antimicrobial resistance. The current study aimed to explore the prevalence of the CRISPR/Cas system in Klebsiella pneumoniae isolates recovered from patients in Egypt in comparison to global strains and correlate the CRISPR/Cas to susceptibility to antimicrobial agents. A total of 181 clinical isolates were PCR-screened for cas and selected antimicrobial resistance genes (ARGs). In parallel, 888 complete genome sequences were retrieved from the NCBI database for in silico analysis. CRISPR/Cas was found in 46 (25.4%) isolates, comprising 18.8% type I-E and 6.6% type I-E*. Multidrug resistance (MDR) and extensive drug resistance (XDR) were found in 73.5% and 25.4% of the isolates, respectively. More than 95% of the CRISPR/Cas-bearing isolates were MDR (65.2%) or XDR (32.6%). No significant difference was found in the susceptibility to the tested antimicrobial agents among the CRISPR/Cas-positive and -negative isolates. The same finding was obtained for the majority of the screened ARGs. Among the published genomes, 23.2% carried CRISPR/Cas, with a higher share of I-E* (12.8%). They were confined to specific sequence types (STs), most commonly ST147, ST23, ST15, and ST14. More plasmids and ARGs were carried by the CRISPR/Cas-negative group than others, but their distribution in the two groups was not significantly different. The prevalence of some ARGs, such as blaKPC, blaTEM, and rmtB, was significantly higher among the genomes of the CRISPR/Cas-negative strains. A weak, nonsignificant positive correlation was found between the number of spacers and the number of resistance plasmids and ARGs. In conclusion, the correlation between CRISPR/Cas and susceptibility to antimicrobial agents or bearing resistance plasmids and ARGs was found to be nonsignificant. Plasmid-targeting spacers might not be naturally captured by CRISPR/Cas. Spacer match analysis is recommended to provide a clearer image of the exact behavior of CRISPR/Cas towards resistance plasmids.
Adsorption of malachite green from aqueous phase by tea stalk powder: Parameters, kinetic, isothermal, and thermodynamic studies

Decolorization of malachite green (MG) from the aqueous phase was investigated using tea stalk powder. The adsorption efficiency decreased with the initial MG concentration, ionic strength of the solution, and heavy metal content. A suitable initial MG concentration of up to 200 mg/L can be accepted because adsorption efficiency of more than 95% is achieved. Various adsorption kinetic models were used to fit the experimental data, and the data obtained was best explained by the pseudo second-order model. The adsorption capacities calculated with the pseudo second-order model at different initial MG concentrations ranging from 24.27 to 158.7 mg/g were very close to the experimental data. The Langmuir isotherm fitted well, and the thermodynamic investigation showed that the adsorption of MG by tea stalk powder was feasible, endothermic, and spontaneous. The regeneration/adsorption experiments indicated that the tea stalk powder remained more than 95% of efficiency after six cycles using NaOH as desorbent and thus could be used many times. In conclusion, tea stalk has considerable potential as a cost-effective adsorbent for the removal of MG.
Non-Newtonian Open Channel Flow — A Simple Method of Estimation of Laminar/Turbulent Transition and Flow Resistance

A simple method is presented for the calculation of the Reynolds number at which a non-Newtonian fluid reaches laminar/turbulent transition in an open channel. As well, a simple approach to the estimation of head losses is presented for non-Newtonian open channel flows in the laminar, transitional or turbulent regimes, enabling the flow depth and velocity to be predicted for various fluids, flow rates and channel geometries. Validation of this approach is provided by a diverse range of 776 experimentally measured open channel flow depths, with good agreement found between the predicted and observed values.
Unlocking Insights in IoT-Based Patient Monitoring: Methods for Encompassing Large-Data Challenges

The remote monitoring of patients using the internet of things (IoT) is essential for ensuring continuous observation, improving healthcare, and decreasing the associated costs (i.e., reducing hospital admissions and emergency visits). There has been much emphasis on developing methods and approaches for remote patient monitoring using IoT. Most existing frameworks cover parts or sub-parts of the overall system but fail to provide a detailed and well-integrated model that covers different layers. The leverage of remote monitoring tools and their coupling with health services requires an architecture that handles data flow and enables significant interventions. This paper proposes a cloud-based patient monitoring model that enables IoT-generated data collection, storage, processing, and visualization. The system has three main parts: sensing (IoT-enabled data collection), network (processing functions and storage), and application (interface for health workers and caretakers). In order to handle the large IoT data, the sensing module employs filtering and variable sampling. This pre-processing helps reduce the data received from IoT devices and enables the observation of four times more patients compared to not using edge processing. We also discuss the flow of data and processing, thus enabling the deployment of data visualization services and intelligent applications.
Proteomic Profiling of Thigh Meat at Different Ages of Chicken for Meat Quality and Development

Chicken age contributes to the meat characteristics; however, knowledge regarding the pathways and proteins associated with meat quality and muscle development are still scarce, especially in chicken thigh meat. Hence, the objective of this study was to elucidate the intricate relationship between these traits by liquid chromatography mass spectrometry at three different ages. A total of 341 differential expressed proteins (DEPs) were screened out (fold change ≥ 1.50 or ≤0.67 and p < 0.05) among 45 thigh meat samples (15 samples per age) of Beijing-You chicken (BYC), collected at the age of 150, 300, or 450 days (D150, D300, and D450), respectively. Subsequently, based on the protein interaction network and Markov cluster algorithm (MCL) analyses, 91 DEPs were divided into 26 MCL clusters, which were associated with pathways of lipid transporter activity, nutrient reservoir activity, signaling pathways of PPAR and MAPK, focal adhesion, ECM-receptor interaction, the cell cycle, oocyte meiosis, ribosomes, taurine and hypotaurine metabolism, glutathione metabolism, muscle contraction, calcium signaling, nucleic acid binding, and spliceosomes. Overall, our data suggest that the thigh meat of BYC at D450 presents the most desirable nutritional value in the term of free amino acids (FAAs) and intramuscular fat (IMF), and a series of proteins and pathways associated with meat quality and development were identified. These findings also provide comprehensive insight regarding these traits across a wide age spectrum.
Free Carrier Front Induced Indirect Photonic Transitions: A New Paradigm for Frequency Manipulation on Chip

Nonlinear degenerate four wave mixing and cross phase modulation are established approaches for all optical frequency manipulation in a silicon chip. These approaches require exact group velocity and/or phase velocity matching of pump, signal, and idler. On the other hand, several experimental demonstrations were presented recently, where frequency of light was changed by a free carrier front propagating in a silicon waveguide. This Doppler-like effect is less known, but has important advantages for frequency manipulation on chip. It requires no phase velocity matching and is not dependent on the shape and duration of the pump pulse. It also allows packet switching and can operate in a pump power independent regime. Here, we shortly review the work on front induced indirect transitions in silicon slow light waveguides. We consider three possible interaction regimes: transmission through the front, reflection from the front, and moving with the front called surfing. We derive analytical equations for the f.