Miracle-dz/UniFAR-FTUs huggingface dataset:
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection

The strategies deployed by antibiotic‐resistant bacteria to counteract host defences are poorly understood. Here, we elucidate a novel host–pathogen interaction resulting in skewing lung macrophage polarisation by the human pathogen Klebsiella pneumoniae. We identify interstitial macrophages (IMs) as the main population of lung macrophages associated with Klebsiella. Single‐cell transcriptomics and trajectory analysis of cells reveal type I IFN and IL10 signalling, and macrophage polarisation are characteristic of infected IMs, whereas Toll‐like receptor (TLR) and Nod‐like receptor signalling are features of infected alveolar macrophages. Klebsiella‐induced macrophage polarisation is a singular M2‐type we termed M(Kp). To rewire macrophages, Klebsiella hijacks a TLR‐type I IFN‐IL10‐STAT6 axis. Absence of STAT6 limits Klebsiella intracellular survival and facilitates the clearance of the pathogen in vivo. Glycolysis characterises M(Kp) metabolism, and inhibition of glycolysis results in clearance of intracellular Klebsiella. Capsule polysaccharide governs M(Kp). Klebsiella also skews human macrophage polarisation towards M(Kp) in a type I IFN‐IL10‐STAT6‐dependent manner. Klebsiella induction of M(Kp) represents a novel strategy to overcome host restriction, and identifies STAT6 as target to boost defences against Klebsiella.
A fast ionised wind in a Star Forming-Quasar system at z~1.5 resolved through Adaptive Optics assisted near-infrared data

Outflows are invoked in co-evolutionary models to link the growth of SMBH and galaxies through feedback phenomena, and from the analysis of both galaxies and Active Galactic Nuclei (AGN) samples at z$\sim1-3$, it is becoming clear that powerful winds are quite common in AGN hosts. High-resolution and high S/N observations are needed in order to uncover the physical properties of the wind through kinematics analysis. We exploited VIMOS, SINFONI and Subaru/IRCS Adaptive Optics data to study the kinematics properties on the scale the host galaxy of XID5395, a luminous, X-ray obscured Starburst/Quasar merging system at z$\sim1.5$ detected in the XMM-COSMOS field, and associated with an extreme [O II] emitter (EW$\sim200$ \AA). We mapped, for the first time, at high resolution the kinematics of the [O III] and H$\alpha$ line complexes and linked them with the [O II] emission. The high spatial resolution achieved allowed us to resolve all the components of the SB-QSO system. Our analysis with a resolution of few kpc reveals complexities and asymmetries in and around the nucleus of XID5395. The velocity field measured via non parametric analysis reveals different kinematic components, with maximum blueshifted and redshifted velocities up to $\simeq1300$ km s$^{-1}$, not spatially coincident with the nuclear core. These extreme values of the observed velocities and the spatial location can be explained by the presence of fast moving material. We also spectroscopically confirm the presence of a merging system at the same redshift of the AGN host. We propose that EW as large as $>150$ \AA\ in X-ray selected AGN may be an efficient criterion to isolate objects associated to the short, transition phase of "feedback" in the AGN-galaxy co-evolutionary path, which will subsequently evolve in an unobscured QSO, as suggested from the different observational evidences we accumulated for XID5395.
The evolution of massive black holes and their spins in their galactic hosts

Future space-based gravitational-wave detectors, such as the Laser Interferometer Space Antenna (LISA/SGO) or a similar European mission (eLISA/NGO), will measure the masses and spins of massive black holes up to very high redshift, and in principle discriminate among different models for their evolution. Because the masses and spins change as a result of both accretion from the interstellar medium and the black hole mergers that are expected to naturally occur in the hierarchical formation of galaxies, their evolution is inextricably entangled with that of their galactic hosts. On the one hand, the amount of gas present in galactic nuclei regulates the changes in the black hole masses and spins through accretion, and affects the mutual orientation of the spins before mergers by exerting gravitomagnetic torques on them. On the other hand, massive black holes play a central role in galaxy formation because of the feedback exerted by active galactic nuclei on the growth of structures. In this paper, we study the mass and spin evolution of massive black holes within a semi-analytical galaxy-formation model that follows the evolution of dark-matter haloes along merger trees, as well as that of the baryonic components (hot gas, stellar and gaseous bulges, and stellar and gaseous galactic discs). This allows us to study the mass and spin evolution in a self-consistent way, by taking into account the effect of the gas present in galactic nuclei both during the accretion phases and during mergers. Also, we present predictions, as a function of redshift, for the fraction of gas-rich black hole mergers – in which the spins prior to the merger are aligned due to the gravitomagnetic torques exerted by the circumbinary disc – as opposed to gas-poor mergers, in which the orientation of the spins before the merger is roughly isotropic. These predictions may be tested by LISA or similar spaced-based gravitational-wave detectors such as eLISA/NGO or SGO.
Large deviations of the current in stochastic collisional dynamics

We consider a class of deterministic local collisional dynamics, showing how to approximate them by means of stochastic models and then studying the fluctuations of the current of energy. We show first that the variance of the time-integrated current is finite and related to the conductivity by the Green–Kubo relation. Next we show that the law of the empirical average current satisfies a large deviations principle and compute explicitly the rate functional in a suitable scaling limit. We observe that this functional is not strictly convex.
X-RAY EMISSION FROM AN ASYMMETRIC BLAST WAVE AND A MASSIVE WHITE DWARF IN THE GAMMA-RAY EMITTING NOVA V407 Cyg

Classical nova events in symbiotic stars, although rare, offer a unique opportunity to probe the interaction between ejecta and a dense environment in stellar explosions. In this work, we use X-ray data obtained with Swift and Suzaku during the recent classical nova outburst in V407 Cyg to explore such an interaction. We find evidence of both equilibrium and non-equilibrium ionization plasmas at the time of peak X-ray brightness, indicating a strong asymmetry in the density of the emitting region. Comparing a simple model to the data, we find that the X-ray evolution is broadly consistent with nova ejecta driving a forward shock into the dense wind of the Mira companion. We detect a highly absorbed soft X-ray component in the spectrum during the first 50 days of the outburst that is consistent with supersoft emission from the nuclear burning white dwarf. The high temperature and short turnoff time of this emission component, in addition to the observed breaks in the optical and UV light curves, indicate that the white dwarf in the binary is extremely massive. Finally, we explore the connections between the X-ray and GeV γ-ray evolution, and propose that the gamma-ray turnoff is due to the stalling of the forward shock as the ejecta reach the red giant surface.
Higher Abel-Jacobi maps for 0-cycles

Starting from the candidate Bloch-Beilinson filtration on Chow groups of 0-cycles constructed by J. Lewis, we develop and describe geometrically a series of Hodge-theoretic invariants defined on the graded pieces. Explicit formulas (in terms of currents and membrane integrals) are given for certain quotients of the invariants, with applications to 0-cycles on products of curves.
The circadian preferences in the context of sociodemographic indicators and lifestyle

ABSTRACT Circadian preferences are frequently used as a synonym for chronotype. Both terms are based on different principles and are measured by a variant questionnaire. We focused on circadian preferences, delimited as an individual preference for the timing of various activities, and their relationship to the selected sociodemographic factors. All participants (n = 2068) filled out online questionnaires including MEQ, MCTQ, and sociodemographic information (age, sex, place of residence, marital status, childcare, education, financial security, physical and mental health). Although the concept of chronotype and circadian preference differ, the mutual correlation was high. Our results of the observed variables are similar to other studies. We revealed evening preference is related to a higher probability of living in a big city, having a single life, a higher risk of smoking, worse health status, and worse financial security. We observed a higher social jet lag among them. Our research complies with previous studies, which found that in some areas, people with evening preferences evince worse results. Due to the evening preference, these people are at a disadvantage, and the society’s setting for morning operations can lead to a deepening of these differences. We recommend further research, which would focus on the practical application of results to the everyday life of participants to create preventive programs aimed at reducing the negative impact of evening preferences on life.
Physical demands in Spanish male and female elite football referees during the competition: a prospective observational study

ABSTRACT Objective The aim of this study was to analyze the physical demands of elite male and female field referees in match play and compare the physical demands between male and female football referees in the competition. Methods Match data were collected from 36 elite football referees (19 males and 17 females) during a total of 409 football matches. Electronic performance and tracking systems based on global positioning systems (GPS) were used in this research. Results Male referees experienced significantly greater physical demands (p < 0.05) in men league than female referees in women league for total distance, explosive distance, high-intensity breaking distance, total of sprints, sprinting distance, high-speed running distance, high-speed running actions, maximal speed, total of accelerations and decelerations, maximal acceleration and deceleration, acceleration/deceleration. Conclusions Therefore, strength and conditioning coaches should consider these gender differences in match demands to maximize the fitness-fatigue response of the referees since this may lead to a better performance during the decision-making process in the competition.
Tuning the stiffness asymmetry of optical tweezers via polarization control

We report an experimental demonstration of tailoring the landscape of the optical potential by using the polarization state of a trap laser beam as a tuning knob. Two groups of polystyrene spheres, i.e., 300 nm and 1 μm, are optically trapped individually to investigate the effect of the intrinsic and a strongly-modified optical field distribution on the resulting trap stiffness, respectively. The angular variations of the orthogonal pair of stiffnesses, kx and ky, with the polarization state of the trap laser beam were systematically analyzed, and the results show that polarization control could provide a wide tuning range of trap-stiffness asymmetry (sT = 1− kx/ky). The implication of asymmetry control of the optical potential is briefly discussed.
Clinical Practice Patterns of Isthmic Spondylolysis in Young Athletes: A Survey of Pediatric Research in Sports Medicine Members

Abstract Isthmic spondylolysis is a common cause of back pain in young athletes. The condition presents to numerous medical providers who employ a variety of different practices in diagnosis and management. The purpose of this study was twofold: to review the literature of diagnosis and management of the young athlete with isthmic spondylolysis and to survey Pediatric Research in Sports Medicine (PRiSM) members during the 2021 PRiSM Annual Meeting on practice patterns of diagnosis and management of the young athlete with isthmic spondylolysis. The response rate was 27%. Per respondents: 24% obtain oblique radiographs; 90% use magnetic resonance imaging as the advanced imaging modality; 60% treat with bracing; 57% recommend rest prior to physical therapy (PT); 53% prescribe return to sport activity restrictions. Although there are similarities in the diagnosis of isthmic spondylolysis in young athletes, this survey confirmed variability in management, especially bracing, timing of PT and return to sport activity restrictions.
Impact of Hedonics and Magnitude Upon Validated Psychophysical Olfactory Tests and Olfactory-Specific Quality of Life

Introduction Patients often describe the olfactory loss as either the inability to detect unpleasant odors (eg, smoke or spoiled food) or noticeable impairment in enjoying pleasant odors (eg, food and fragrances). This complex relationship between the hedonics of various odors, their perceived magnitude in odor strength, and the impact on patient quality of life is not well understood. Methods Sixty-five subjects underwent testing with the Henkin olfaction test which assesses hedonics and magnitude for odors traditionally deemed unpleasant (pyridine/dead fish and thiophene/gasoline) and pleasant (amyl acetate/banana and nitrobenzene/almond). Subjects also completed Smell Identification Test-40 (SIT-40), Sniffin’ Sticks (Sniffin’ Sticks), and Snap & Sniffin’ Sticks (Snap) Olfactory Tests, as well as the 17-item Questionnaire for Olfactory Disorders Negative Statements (QODNS) and olfactory symptom visual analog scale (VAS). Spearman's rank correlations were conducted between various olfactory domains, QODNS and VAS. Results Mean age was 52.1 years (range: 28-86), with 63.1% females. Magnitude estimation was greatest for pyridine. Most people rated thiophene (75.4%) and pyridine (92.3%) as “unpleasant. ” Although most people rated amyl acetate (47.7%) and nitrobenzene (56.9%) as “pleasant,” many rated amyl acetate (52.3%) and nitrobenzene (43.1%) as “neutral” or “unpleasant” scents. Hedonics for unpleasant odors correlated with each other (rs = 0.60), but not with hedonics for pleasant odors. Hedonics for unpleasant odors also correlated with magnitude estimation and other psychophysical tests. These findings were not seen for hedonics of pleasant odors. Conclusions The use of unpleasant odors in Henkin testing showed unique relationship patterns with patient-reported outcome measures and validated olfactory tests, which may provide utility in characterizing olfactory dysfunction. The incorporation of more unpleasant odors in current psychophysical olfactory testing may provide enhanced information regarding the patient impact of olfactory dysfunction.
Defibrillation Strategies for Refractory Ventricular Fibrillation.

BACKGROUND Despite advances in defibrillation technology, shock-refractory ventricular fibrillation remains common during out-of-hospital cardiac arrest. Double sequential external defibrillation (DSED; rapid sequential shocks from two defibrillators) and vector-change (VC) defibrillation (switching defibrillation pads to an anterior-posterior position) have been proposed as defibrillation strategies to improve outcomes in patients with refractory ventricular fibrillation. METHODS We conducted a cluster-randomized trial with crossover among six Canadian paramedic services to evaluate DSED and VC defibrillation as compared with standard defibrillation in adult patients with refractory ventricular fibrillation during out-of-hospital cardiac arrest. Patients were treated with one of these three techniques according to the strategy that was randomly assigned to the paramedic service. The primary outcome was survival to hospital discharge. Secondary outcomes included termination of ventricular fibrillation, return of spontaneous circulation, and a good neurologic outcome, defined as a modified Rankin scale score of 2 or lower (indicating no symptoms to slight disability) at hospital discharge. RESULTS A total of 405 patients were enrolled before the data and safety monitoring board stopped the trial because of the coronavirus disease 2019 pandemic. A total of 136 patients (33.6%) were assigned to receive standard defibrillation, 144 (35.6%) to receive VC defibrillation, and 125 (30.9%) to receive DSED. Survival to hospital discharge was more common in the DSED group than in the standard group (30.4% vs. 13.3%; relative risk, 2.21; 95% confidence interval [CI], 1.33 to 3.67) and more common in the VC group than in the standard group (21.7% vs. 13.3%; relative risk, 1.71; 95% CI, 1.01 to 2.88). DSED but not VC defibrillation was associated with a higher percentage of patients having a good neurologic outcome than standard defibrillation (relative risk, 2.21 [95% CI, 1.26 to 3.88] and 1.48 [95% CI, 0.81 to 2.71], respectively). CONCLUSIONS Among patients with refractory ventricular fibrillation, survival to hospital discharge occurred more frequently among those who received DSED or VC defibrillation than among those who received standard defibrillation. (Funded by the Heart and Stroke Foundation of Canada; DOSE VF ClinicalTrials.gov number, NCT04080986.).
Three loop analysis of the critical O (N) models in 6-ε dimensions

We continue the study, initiated in arXiv:1404.1094, of the $O(N)$ symmetric theory of $N+1$ massless scalar fields in $6-\epsilon$ dimensions. This theory has cubic interaction terms $\frac{1}{2}g_1 \sigma (\phi^i)^2 + \frac{1}{6}g_2 \sigma^3$. We calculate the 3-loop beta functions for the two couplings and use them to determine certain operator scaling dimensions at the IR stable fixed point up to order $\epsilon^3$. We also use the beta functions to determine the corrections to the critical value of $N$ below which there is no fixed point at real couplings. The result suggests a very significant reduction in the critical value as the dimension is decreased to $5$. We also study the theory with $N=1$, which has a $Z_2$ symmetry under $\phi\rightarrow -\phi$. We show that it possesses an IR stable fixed point at imaginary couplings which can be reached by flow from a nearby fixed point describing a pair of $N=0$ theories. We calculate certain operator scaling dimensions at the IR fixed point of the $N=1$ theory and suggest that, upon continuation to two dimensions, it describes a non-unitary conformal minimal model.
THE RELATION BETWEEN GALAXY STRUCTURE AND SPECTRAL TYPE: IMPLICATIONS FOR THE BUILDUP OF THE QUIESCENT GALAXY POPULATION AT 0.5 < z < 2.0

We present the relation between galaxy structure and spectral type, using a K-selected galaxy sample at 0.5 < z < 2.0. Based on similarities between the UV-to-NIR spectral energy distributions (SEDs), we classify galaxies into 32 spectral types. The different types span a wide range in evolutionary phases, and thus—in combination with available CANDELS/F160W imaging—are ideal to study the structural evolution of galaxies. Effective radii (Re) and Sérsic parameters (n) have been measured for 572 individual galaxies, and for each type, we determine Re at fixed stellar mass by correcting for the mass-size relation. We use the rest-frame U − V versus V − J diagram to investigate evolutionary trends. When moving into the direction perpendicular to the star-forming sequence, in which we see the Hα equivalent width and the specific star formation rate (sSFR) decrease, we find a decrease in Re and an increase in n. On the quiescent sequence we find an opposite trend, with older redder galaxies being larger. When splitting the sample into redshift bins, we find that young post-starburst galaxies are most prevalent at z > 1.5 and significantly smaller than all other galaxy types at the same redshift. This result suggests that the suppression of star formation may be associated with significant structural evolution at z > 1.5. At z < 1, galaxy types with intermediate sSFRs (10−11.5–10−10.5 yr−1) do not have post-starburst SED shapes. These galaxies have similar sizes as older quiescent galaxies, implying that they can passively evolve onto the quiescent sequence, without increasing the average size of the quiescent galaxy population.
New epitaxial thin‐film models and numerical approximation

This paper concerns new continuum phenomenological model for epitaxial thin‐film growth with three different forms of the Ehrlich–Schwoebel current. Two of these forms were first proposed by Politi and Villain 1996 and then studied by Evans, Thiel, and Bartelt 2006. The other one is completely new. Energy structure and properties of the new model are studied. Following the techniques used in Li and Liu 2003, we present rigorous analysis of the well‐posedness, regularity, and time stability for the new model. We also studied both the global and the local behavior of the surface roughness in the growth process. By using a convex–concave time‐splitting scheme, one can naturally build unconditionally stable semi‐implicit numerical discretizations with linear implicit parts, which is much easier to implement than conventional models requiring nonlinear implicit parts. Despite this fundamental difference in the model, numerical experiments show that the nonlinear morphological instability of the new model agrees well with results of other models published before which indicates that the new model correctly captures the essential morphological states in the thin‐film growth process. Copyright © 2017 John Wiley & Sons, Ltd.
Concerning perceived and clinically-measured levels of halitosis

The different types of self-reported halitosis complaints include those where one feels that one’s breath smells bad, where one feels that one has bad breath because of the attitudes of others, and where others have pointed out the presence of bad breath. The results of previous studies comparing the objective and subjectives measures of halitosis are inconsistent, and few studies have used gas chromatography (GC) to measure halitosis in a large sample. This study aimed to examine the objectively measured halitosis levels based on the reasons individuals are concerned about halitosis. We included 2063 patients who visited the halitosis clinic at a university dental hospital. Halitosis was assessed using GC, self-administered questionnaires, and oral examinations. Levels of volatile sulphur compounds (VSCs; H2S, CH3SH, and (CH3)2S) were set as objective measures of halitosis. Patients were grouped based on their answers to ‘What made you concerned about bad breath? ’ into groups: ‘self-perceived,’ ‘attitudes of others,’ ‘told by others,’ and other reasons. Univariate and multivariable linear regression analyses were performed to examine factors associated with VSCs and objective halitosis levels. Age, sex, oral health status, smoking, drinking, and breakfast habits were used as confounders. Patients who answered ‘told by others’ (n = 691, 33.5%) showed the highest VSCs. Individuals whose halitosis was pointed out by others had higher objectively measured halitosis levels, while those concerned about the attitudes of others or perceived their own halitosis had lower objectively measured halitosis levels. These results suggest that the objective level of halitosis can differ on the basis of the reason underlying an individual’s concern about their bad breath. Categorizing halitosis complaints and comparing them with objective halitosis levels may help reduce the anxiety of those who are concerned about halitosis and confirm the need for intervention for those with objective halitosis.