Miracle-dz/UniFAR-FTUs huggingface dataset:
OPTIONS FOR MODELING THE DISTRIBUTIONAL IMPACT OF CARE POLICIES USING A GENERAL EQUILIBRIUM (CGE) FRAMEWORK

This working paper is part of the Care Work and the Economy Project(CWE-GAM), as part of the Program on Gender Analysis in Economics (PGAE) at American University’s Department of Economics. The authors would like to acknowledge the support of the Hewlett Foundation for this report as part of the Project. The findings, views, and conclusions or recommendations expressed in this material are strictly those of the authors and do not necessarily reflect those of the Hewlett Foundation.
BTT_A_259124 379..397

1Sunnybrook Research Institute, Toronto, ON, Canada; 2Department of Surgery, Division of Plastic Surgery, University of Toronto, Toronto, ON, Canada; 3Department of Immunology, University of Toronto, Toronto, ON, Canada; 4Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada Abstract: Burn injuries affect approximately 11 million people annually, with fatalities amounting up to 180,000. Burn injuries constitute a global health issue associated with high morbidity and mortality. Recent years have seen advancements in regenerative medicine for burn wound healing encompassing stem cells and stem cell-derived products such as exosomes and conditioned media with promising results compared to current treatment approaches. Sources of stem cells used for treatment vary ranging from hair follicle stem cells, embryonic stem cells, umbilical cord stem cells, to mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, bone marrow-derived mesenchymal stem cells, and even stem cells harvested from discarded burn tissue. Stem cells utilize various pathways for wound healing, such as PI3/AKT pathway, WNT-β catenin pathway, TGF-β pathway, Notch and Hedgehog signaling pathway. Due to the paracrine signaling mechanism of stem cells, exosomes and conditioned media derived from stem cells have also been utilized in burn wound therapy. As exosomes and conditioned media are cell-free therapy and contain various biomolecules that facilitate wound healing, they are gaining popularity as an alternative treatment strategy with significant improvement in outcomes. The treatment is provided either as direct injections or embedded in a natural/artificial scaffold. This paper reviews in detail the different sources of stem cells, stem cell-derived products, their efficacy in burn wound repair, associated signaling pathways and modes of delivery for wound healing.
Trophic Structure and Diet of Predatory Teleost Fishes in a Tropical Demersal Shelf Ecosystem

Predatory fishes are a major component of many tropical fisheries, although little is known about their diet and trophic structure, which can hinder effective management. We used stable isotopes δ15N and δ13C in conjunction with dietary prey items of five fishes (Lutjanus sebae, Lethrinus punctulatus, Epinephelus areolatus, Epinephelus multinotatus, and Plectropomus maculatus) to describe the diet and trophic structure across this assemblage. A total of 153 isotope and 87 stomach content samples were collected at two locations that were ≈30 km apart, over two sampling trips, separated by three months. There was clear separation of species’ mean δ15N and δ13C values in isotopic space; the highest mean δ15N was exhibited by E. multinotatus (13.50 ± 0.11 SE) and the lowest was L. punctulatus (11.05 ± 0.13). These two species had the lowest overlap of isotopic niche space, whereas the highest overlap occurred between L. sebae and P. maculatus. δ15N increased with fish body size for all species. However, body size was not significantly related to δ13C values for any species. There was a notable shift in both δ15N and δ13C between sampling trips, with δ13C being more depleted in the second trip. There was also a difference in δ13C between locations for all species, suggesting localised foraging. A multiple tissue comparison for L. sebae indicated positive relationships for both δ15N and δ13C between dorsal fin and muscle tissue. Mean δ15N values were the same for both fin (12.1 ± 0.10 SE) and muscle tissue (12.1 ± 0.09 SE), although δ13C was more enriched in fin (-15.6 ± 0.14 SE) compared to muscle tissue (-17.3 ± 0.11 SE). The most common dietary items across species were teleosts and crustaceans, which was consistent with isotope data indicating a reliance on a demersal food web (δ13C values ranging from -18 to -15‰). The results from our study indicate a dynamic spatio-temporal trophic structure and diet for commercially important demersal species and highlight the benefits of a multi-facetted sampling approach.
Subcutaneous Adipose Tissue Accumulation Is an Independent Risk Factor of Urinary Stone in Young People

Background Urinary stones usually start at a young age and tend to recur. Therefore, preventing stone occurrence and recurrence in young people is crucial. We aimed to investigate the association between subcutaneous adipose tissue, visceral adipose tissue, and stone episodes in young people. Methods We retrospectively studied patients aged below 40 years with kidney or ureteral stones. Data on demographic and metabolic characteristics, urolithiasis history, subcutaneous fat area (SFA), and visceral fat area (VFA) were collected. We evaluated the association between SFA or VFA and the occurrence or recurrence of stone episodes using binary logistic regression and Poisson regression analyses. Results In total, 120 patients were included. Abdominal obesity, overweight or obesity, dyslipidemia, metabolic syndrome, SFA, and VFA increased with the number of stone episodes (all p < 0.05). The increase in SFA was independently associated with episode occurrence (p = 0.015). Patients with an SFA > 97 cm2 had a higher risk of episode occurrence. SFA and VFA accumulation were independently associated with episode recurrence (all p < 0.05), and SFA had a stronger association than VFA did. Conclusions In young people, SFA accumulation is an independent and early risk factor for the occurrence and recurrence of stone episodes. Subcutaneous fat could be a convenient and effective indicator to assess the risk of stone episodes before the development of metabolic disorders.
ON OBSERVER-BASED FAULT DETECTION AND ISOLATION FOR CONTINUOUS LINEAR DESCRIPTOR SYSTEMS 1

Abstract Conditions for existence of observer-based faults detection and isolation systems for continuous linear descriptor systems are presented. These conditions are associated, in a first phase, to the solution of a generalized Sylvester equation and, in a second phase, to the solution of a Sylvester equation under a constraint that describes the faults decoupling of the corresponding estimation error. Two observer structures are used to residual generation and faults reconstruction/isolation, respectively. The proposed results put in evidence some degrees of freedom that can be used for design purposes. Thus, an eigenstructure assignment algorithm to design the FDI system and a illustrative example are presented.
Implementation of Entrepreneurship-Based Vocational Education (Multi Site Study at Slb Negeri 1 Martapura Dan Slb-C Negeri Pembina Provinsi Kalimantan Selatan)

The purpose of this research is to describe and examine the principal's leadership in the two great schools. A multi-site qualitative technique is used in this study. The principal, deputy head of public relations, and deputy curriculum served as informants in this investigation. In-depth interviews, participant observations, and documentation were used to collect data. The stages of study were data collecting, data reduction, data presentation, and generating conclusions, which were examined utilizing an interactive data analysis model from Miles (2005). The findings' validity was verified using triangulation technique. The results showed that (1) Professional competences in offering educational innovations are the outputs of Teacher Competence by mobilizing teachers and learning teachers maximized at SLB Negeri 1 Martapura. At SLB-C Negeri Pembina through pedagogic competence in providing skills facilitated by the school; (2) Readiness of school infrastructure at SLB Negeri 1 Martapura, the availability of supporting facilities and optimizing them. SLB-C Negeri Pembina has complete facilities to support learning; (3) The school seeks partnerships with parents to foster and motivate learners in applying skills. At SLB Negeri 1 Martapura by applying the partnership model. In SLB-C Negeri Pembina by applying the client model; (4) Development of business plans and provision of work experience at SLB Negeri 1 Martapura by providing coaching and skills activities in schools. In SLB-C Negeri Pembina is to prepare additional expertise oriented to the business world and the industrial world.
Correct Use of Three-Point Seatbelt by Pregnant Occupants

The largest cause of accidental death and placental abruption in pregnancy is automobile collisions. Lives can be saved by correct use of the three-point seatbelt during pregnancy. Human interaction is essential for correct use of seatbelts. The objective of this study is to investigate pregnant women’s use of correct shoulder section together with correct lap section as advised by obstetricians and highway experts and to identify the most common seatbelt misuse during pregnancy. An international web survey was conducted in five languages for this study. 1931 pregnant women reported their use of seatbelts and how they position the shoulder and lap sections of their seatbelts. Special attention was paid to distinguish between ‘partly correct’ and ‘correct’ seatbelt positioning. The questionnaire responses are used to determine the magnitude of every combination of the correct and incorrect shoulder and lap section of the seatbelt positioning during pregnancy. Results show that seatbelt usage in pregnancy is generally high in the world. However, the correct use of the entire seatbelt is very low, at only 4.3% of all respondents. 40.8% of the respondents use the shoulder portion of the belt correctly, whilst a 13.2% use the lap section correctly. The most common misuse is ‘across abdomen’ or ‘not using the seatbelt at all’, and both pose danger to pregnant women and their fetuses. Correct use of three point seatbelts is a challenge during pregnancy. We recommend that the media, medical community, and automotive industry provide targeted information about correct seatbelt use during pregnancy and accident databases include ‘correct seatbelt use’ information in crash statistics.
CUL3 and COPS5 Related to the Ubiquitin-Proteasome Pathway Are Potential Genes for Muscle Atrophy in Mice

Sarcopenia is a condition that reduces muscle mass and exercise capacity. Muscle atrophy is a common manifestation of sarcopenia and can increase morbidity and mortality in specific patient populations. The aim of this study was to identify novel prognostic biomarkers for muscle atrophy and associated pathway analysis using bioinformatics methods. The samples were first divided into different age groups and different muscle type groups, respectively, and each of these samples was analyzed for differences to obtain two groups of differentially expressed genes (DEGs). The two groups of DEGs were intersected using Venn diagrams to obtain 1,630 overlapping genes, and enrichment analysis was performed to observe the Gene Ontology (GO) functional terms of overlapping genes and the enrichment of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Subsequently, WGCNA (weighted gene coexpression network analysis) was used to find gene modules associated with both the age and muscle type to obtain the lightgreen module. The genes in the key modules were analyzed using PPI, and the top five genes were obtained using the MCC (maximum correntropy criterion) algorithm. Finally, CUL3 and COPS5 were obtained by comparing gene expression levels and analyzing the respective KEGG pathways using gene set enrichment analysis (GSEA). In conclusion, we identified that CUL3 and COPS5 may be novel prognostic biomarkers in muscle atrophy based on bioinformatics analysis. CUL3 and COPS5 are associated with the ubiquitin-proteasome pathway.
Guided Awareness of Dual Consciousness States in Meditation

: This research work is a sustained attempt to scientifically interpret the Meditative Guidance of the Divine Omdasji Sound Meditation (SR0000398348 dated 2006-09-13, United States Copyright Office) renowned to bring peace and calm to the meditating human subject. It is the outcome of inspiration dawned on the authors to scientifically investigate such phenomena connected with the Divine Omdasji Sound Meditation. The Divine Omdasji Sound Meditation has been found to have many properties that Science can explain. accompanied with BioPhotonic Communication, Meditative Consciousness & BioAcoustic Fields and Multiple Phase Locked Loops are used to analyze the Divine Omdasji Sound Meditation. Meditative guidance characteristics for multiple subjects at various levels are exhibited by the inference from the experimental results. This work concentrates on presenting a unique phenomenon of guided dual consciousness state awareness in meditation.
DURING EARLY STAGE OF THE HEART DEVELOPMENT: AN IN VITRO MODEL UTILIZING MOUSE EMBRYONIC STEM CELL

Many developmental studies have focused on the role of Ca 2+ signal ing in early events after ferti lization. Studies performed ti ll now in both embryos and embryonic stem (ES) cel l di fferentiat ing to cardiomyocytes have uncovered the role of Ca 2+ in cardiac development in mouse. The data of the present study using ES cells suggest that the biological effects of Ca 2+ through p44/42 MAPK activat ion on cardiac cel l di fferentiation and proli feration. It was been found that expression of cardiac transcription factors increased when 10 μM ionomycin was added to the cel l culture medium and significantly inhibited by adding 50 μM BAPTA. The decrease in expression of transcription myocyte enhancer factor C2 (Mef2c), GATA4 and Nkx2.5 that ini tiates the program for cardiac gene expression for cardiomyocyte dif ferentiation, resulting in an impaired cardiomyocytes differentiat ion and organization of myofibr i ls. To further investigate the relat ion between cytosol ic [Ca 2+ ]c and the cardiac sarcomeric genes and protein expression of ES cel ls were analysed by reverse transcription-polymerase chain reaction (RTPCR) and western blot. The results showed that the cahnge of cardiac transcription factors expression accompanied with change in genes and protein expression of α-myocine havey chain (α-MHC), ß-MHC, cardiotropinin T and ventr icular myosin light chain 2 (MLC2v) but not in gene and protein expression of atrial myosin l ight chain 2 (MLC2a). Interestingly, treatment the EBs with Ca 2+ ionophore, to el icit an increase in [Ca 2+ ]c, for 2 days after treatment the EBs for 5 days with Ca 2+ chelator could par tially rescue but not completely the effect of absence a Ca 2+ in early time of cardiac development. In conclusion, these data suggest that s ignaling pathways involved in embryonic cardiomyogenesis are affected by Ca 2+ concentrat ion during the heart development.
Force Transmission in Disordered Fibre Networks

Cells residing in living tissues apply forces to their immediate surroundings to promote the restructuration of the extracellular matrix fibres and to transmit mechanical signals to other cells. Here we use a minimalist model to study how these forces, applied locally by cell contraction, propagate through the fibrous network in the extracellular matrix. In particular, we characterize how the transmission of forces is influenced by the connectivity of the network and by the bending rigidity of the fibers. For highly connected fiber networks the stresses spread out isotropically around the cell over a distance that first increases with increasing contraction of the cell and then saturates at a characteristic length. For lower connectivity, however, the stress pattern is highly asymmetric and is characterised by force chains that can transmit stresses over very long distances. We hope that our analysis of force transmission in fibrous networks can provide a new avenue for future studies on how the mechanical feedback between the cell and the ECM is coupled with the microscopic environment around the cells.
Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss

Obesity and asthma are associated with systemic inflammation maintained by mediators released by adipose tissue and lung. This study investigated the inflammatory serum mediator profile in obese subjects (O) (n = 35), non-obese asthma (NOA) patients (n = 14), obese asthmatics (OA) (n = 21) and healthy controls (HC) (n = 33). The effect of weight loss after bariatric surgery (BS) was examined in 10 OA and 31 O subjects. We analyzed serum markers including leptin, adiponectin, TGF-β1, TNFR2, MCP-1, ezrin, YKL-40, ST2, IL-5, IL-9, and IL-18. Compared with HC subjects, the O group showed increased levels of leptin, TGF-β1, TNFR2, MCP-1, ezrin, YKL-40, and ST2; the OA group presented increased levels of MCP-1, ezrin, YKL-40, and IL-18, and the NOA group had increased levels of ezrin, YKL-40, IL-5, and IL-18. The higher adiponectin/leptin ratio in NOA with respect to OA subjects was the only significant difference between the two groups. IL-9 was the only cytokine with significantly higher levels in OA with respect to O subjects. TNFR2, ezrin, MCP-1, and IL-18 concentrations significantly decreased in O subjects after BS. O, OA, and NOA showed distinct patterns of systemic inflammation. Leptin and adiponectin are regulated in asthma by obesity-dependent and -independent mechanisms. Combination of asthma and obesity does not result in significant additive effects on circulating cytokine levels.
Digital Citizenship, Self-Esteem and Life Satisfaction: An Assessment of the Geographical Differentials and Demographic Factors in the Context of Saudi Arabia

Living in the new era of globalization has been enhanced by ubiquitous information and communication technologies. These advancements in communication technology introduce many consequences in a person’s life and impact the psychology of potential users and may lead to many psychological concerns. This study examines the impact of digital citizenship and considered the effects of digital life on self-esteem and the potential mediating role of life satisfaction. The cross-sectional research design uses a purposive non-probability sampling technique with a population of 2597 Saudis with formal education. Data were collected via multiple research questionnaires: to assess individuals ‘concept of digital citizenship, the Digital Citizenship Questionnaire developed by Nordin et al. (2016); to measure self-esteem, Webster et al. (2020) state self-esteem scale; and to measure life satisfaction, the Satisfaction with Life Scale developed by Diener et al. (1985). It has been observed significant associations fall the dimensions of digital citizenship with self-esteem and life satisfaction, while life satisfaction played a significant mediation role between digital citizenship and self-esteem. Findings of the results address useful insights about the digital citizenship construct and its relationship with psychological attributes of self-esteem and life satisfaction. The results will significantly contribute to the field of digital marketing, and digital network-based organizations and enhances the knowledge about digital citizenship along with the responsibilities and ethical use of digital technology in the respective firms.
Sum-ordered partial semirings

If we endow the set of partial functions from a data set to itself with an addition (disjoint-domain sums) and a multiplication (functional composition), then any iterative algorithm may be described formally as the solution to a matrix equation, where the matrix entries are partial functions which describe the parts of the algorithm. This suggests that algorithms may be transformed by manipulation of matrices of partial functions. Hence, it becomes necessary to understand how such matrices behave. The partial functions under disjoint-domain sums and functional composition do not form a field, and thus conventional linear algebra is not applicable. However, they can be regarded as a sum-ordered partial semiring or "so-ring", an algebraic structure possessing a natural partial ordering, an infinitary partial addition, and a binary multiplication, subject to a set of axioms. The majority of this dissertation is devoted to a detailed study of the properties and interesting substructures of so-rings themselves; preliminary results illustrating the behavior of matrices over so-rings are also presented. We hope that this study in part provides a basis for a matrix theory of algorithm transformation.
Brief Sensations Seeking Scale (BSSS): Validity Evidence in Mexican Adolescents

Sensation seeking is a construct associated with risky behaviors over a wide age range, but validation studies in Mexico are lacking. The aim of this study was to investigate the validity of two versions of the Brief Sensation Seeking Scale (the BSSS-8 and BSSS-4) in young Mexican individuals. The sample consisted of 2884 students (age: M = 16.6, SD = 1.5) from five preparatory schools in Morelos, Mexico. The internal structure of the BSSS was evaluated according to the structural equation modeling (SEM) parameterization, including measurement invariance (compared to the factor loadings obtained in the meta-analysis); conditional reliability; and equivalence between versions. The unidimensionality and measurement invariance (configurational, factor loadings, thresholds, intercepts, and residuals) across sex and age groups were satisfactory, and the factor loadings were highly congruent with those obtained in the meta-analysis. Reliability was suitably high (greater than 0.80), especially near the mean scores, but was lower for extreme scores. Thus, the instrument was concluded to be optimal for defining the construct of sensation seeking, consistent with the findings of previous studies.
Ex Post Risk Management in Public-Private Partnership Infrastructure Projects

Public-private partnerships (PPPs) have been widely used in infrastructure development in the past 30 years. However, a number of PPP projects have suffered serious risk scenarios and ended up with project failures. The change from a short-term contract period of traditional projects (fewer than five years) to a long-term contract period of PPP projects (20–30 years) has raised challenges to the traditional risk management. The high occurrence of renegotiations and early terminations of PPP projects suggest that ex ante risk management is no longer enough and ex post risk management is needed. This study aims to propose an ex post risk management model, under which renegotiations and early terminations are introduced. The application of this model begins with risk impact evaluation, then ex post risk response measures assessment, selection, and enforcement. An illustrative case is provided in the Appendix at the end of the article. The outputs of this study would facilitate governments’ decision making in PPP projects under serious risk scenarios.