Miracle-dz/UniFAR-FTUs huggingface dataset:
Value of combining the serum d-lactate, diamine oxidase, and endotoxin levels to predict gut-derived infections in cancer patients

Abstract Objective This is a retrospective observational cohort study. The objective of this retrospective observational cohort study was to evaluate the value of the combined serum d-lactic acid, diamine oxidase (DAO), and endotoxin levels to predict intestinal barrier impairment and gut-derived infection (GDI) in cancer patients. Methods Cancer patients receiving chemotherapy or palliative care treatment at our hospital were enrolled in the study. The serum concentrations of DAO, d-lactic acid, and endotoxin were determined using the intestinal barrier function biochemical index analysis system. The patients' infection information came from the hospital's Medicom Prescription Automatic Screening System and the medical records. Three hundred fifty-three cancer patients were included in the study (53.8% female, 73.7% cancer stage IV, 27.8% had bowel obstruction). Results The total incidence of GDI was 33.4% (118/353). The median length of hospital stay was 16 days for patients with GDI, compared with 7 days for patients without GDI (P < 0.001). The media hospitalization costs were ¥27,362.35 for patients with GDI compared with ¥11,614.08 for patients without GDI (P < 0.001). The serum concentrations of DAO, d-lactic acid, and endotoxin were significantly higher in patients with GDI. As malignant bowel obstruction (MBO) worsened, the concentrations of DAO, d-lactic acid, and endotoxin increased. Multivariate logistic regression models revealed that the DAO, endotoxin, IL-6, and C-reactive protein levels were significantly associated with an increased risk of GDI. In addition, we also found a fivefold increased risk of infection in patients with MBO compared with those without bowel obstruction (OR = 6.210, P < 0.001). All of the areas under the receiver operating characteristic curve (AUCs) for DAO, d-lactate, and endotoxin to predict GDI were <0.7 (AUC = 0.648, P < 0.001; AUC = 0.624, P < 0.01; AUC = 0.620, P < 0.01, respectively). However, when the parameters were combined (DAO + d-lactate + endotoxin), the predictive power increased significantly (AUC = 0.797, P < 0.001). Moreover, combining these intestinal barrier indicators and the presence of MBO had better power to predict GDI than either alone (AUC = 0.837, P < 0.001). Conclusions Combining the serum DAO, d-lactic acid, and endotoxin levels was a better predictor of GDI than any of the indicators alone, and combining these with the diagnosis of MBO could further improve the efficacy for predicting GDI.
Application of surgical pleth index in the opioid-free anesthesia: A randomized controlled trial

Background: Currently, there is no gold standard for monitoring noxious stimulation during surgery, and the surgical pleth index (SPI) is only one of many monitoring methods. It is commonly used in the monitoring of conventional opiate anesthesia, but its effectiveness in opioid-free anesthesia (OFA) has not been evaluated. Therefore, the aim of this study was to observe the guidance value of the surgical pleth index in opioid-free anesthesia for patients undergoing lower abdominal or pelvic surgery. Methods: A total of 122 patients who underwent lower abdominal or pelvic surgery in our hospital between March 2021 and July 2022 were selected and equally divided into OFA (F) and control (C) groups according to the random number table method. Both groups underwent ultrasound-guided unilateral/bilateral quadratus lumborum block in the supine position according to the surgical field. In group F, 0.50% lidocaine and 0.20% ropivacaine (in 20 mL of 0.9% normal saline) were injected on each side. In group C, 20 mL 0.9% normal saline was injected on each side. Group F received general anesthesia without opioids and group C received general anesthesia with opioids. BP, pulse oxygen saturation, PETCO2, reactionentropy, stateentropy, and SPI values; Steward score; dosage of propofol, dexmedetomidine, rocuronium, and diltiazem; extubation time; and awake time were monitored in both groups. Results: There were no significant differences in the general data between the 2 groups (P > .05). There were no significant differences in SPI values at T0, T1, T2, T3, T4, and T5 or the number of cases requiring additional remifentanil, propofol, and diltiazem between the 2 groups (P > .05). The stateentropy, reactionentropy, and Steward scores were higher in group F than in group C at T4 and T5, while the extubation and awake times were lower in group F than in group C (P < .05). The heart rate and SPI of group F were lower than that of group C at T3 (P < .05). Conclusion: The guiding value of SPI in OFA was similar to its use in opiated anesthesia. Its clinical efficacy is exact, vital signs are stable, enabling rapid, and complete regaining of consciousness.
Complex Posttraumatic Stress Disorder and a Biopsychosocial Model of Borderline Personality Disorder

Abstract This review offers a critique of recent attempts to reconceptualize some cases of borderline personality disorder (BPD) within the newer diagnosis of complex posttraumatic stress disorder (CPTSD). The CPTSD construct focuses on the role of childhood trauma in shaping relational problems in adulthood, difficulties that have been previously seen as features of a personality disorder. The CPTSD model fails to consider the role of heritable personality traits, as well as a broader range of psychosocial risk factors. This review proposes that a biopsychosocial model of BPD is more comprehensive, taking into account a wider range of risk factors, while viewing BPD as rooted in gene-environment interactions. In this model, heritable traits are amplified by an adverse psychosocial environment. One can acknowledge the role of trauma as a risk factor without assuming that it fully accounts for the development of personality pathology.
Efficacy and safety of compound glycyrrhizin in combination with conventional therapy in treatment of vitiligo: A systematic review and meta-analysis of randomized controlled trials

Background: Vitiligo is an acquired chronic depigmentary disorder affecting approximately 0.5% to 1% of individuals worldwide. The compound glycyrrhizin (CG), a complementary medicine, has been reported for treatment of vitiligo, but the evidence has not been systematically evaluated. We systematically assessed the efficacy and safety of CG in combination with conventional therapy for the treatment of vitiligo. Methods: We searched Embase, Web of Science, PubMed, The Cochrane Library, Chinese BioMedical Literature Database (CBM), Wanfang Data, China National Knowledge Infrastructure (CNKI), and VIP information from inception to July 2022. Randomized controlled trials comparing CG combined with conventional therapy with conventional therapy alone for vitiligo were included in our analysis. The primary outcome was treatment response, which defined as >50% repigmentation rate of vitiligo after treatment. The secondary outcome was incidence of adverse events. Meta-analysis was performed using the Review Manager 5.4 software. Statistical heterogeneity was evaluated with chi-square and I2 statistics, dichotomous data were expressed as risk ratios (RR) with 95% confidence intervals using the Mantel–Haenszal method. Results: Thirty-nine studies enrolling with 3994 participants were subjected to this review. The results of our meta-analysis indicated that addition of CG had superior effectiveness on repigmentation rate than phototherapy (RR = 1.28; P < .001), immunosuppressant (RR = 1.76; P < .001), traditional Chinese medicine (RR = 1.38; P < .001), combination of phototherapy and immunosuppressant (RR = 1.42; P < .001), and combination of phototherapy and traditional Chinese medicine (RR = 1.37; P < .001). In addition, CG did not increase the incidence of adverse events for vitiligo (RR = 0.79; P = .05). Conclusions: CG as a complementary medicine has a potential benefit in treatment of vitiligo. However, since the methodological flaws in the studies we included, more high-quality randomized controlled trials are warranted.
Patient considerations in the treatment of COPD: focus on the new combination inhaler fluticasone furoate/umeclidinium/vilanterol

: The pharmacological treatment for stable COPD is based on the use of inhaled bronchodilators (long-acting muscarinic receptor antagonists and long-acting beta-2 adreno-ceptor agonists) and inhaled corticosteroids. The use of triple inhaled therapy is recommended to selected patients with COPD. Among the various inhaler combinations in triple therapy, a new combination by fluticasone furoate, umeclidinium, and vilanterol is available for COPD patients. Recently, a large clinical trial using this combination has been published, resulting in a reduction in exacerbation rate in COPD patients. Furthermore, this combination has demonstrated efficacy and safety, with a single administration a day, through a dry powder inhalator device, which has shown a good adherence and is a preference of the patient. This review focuses on the main characteristics of this inhaler combination evaluating the main clinical effects, the patients’ adherence, and the safety.
Use of the pulsation to control a polydispersed particles flow in a new type of pulsed column

: New internals have been designed and implemented in a semi-industrial continuous solid-liquid pulsed column. By coupling these internals with a non sinusoidal pulsation, a better control of polydispersed solid particles is achieved. The pulsation is composed of a mixing step during which only the liquid flows through the column and an impulsion step designed to transport the solid phase from stage to stage. Solid and liquid phase behaviours are characterized thanks to residence time distribution measurements. This study demonstrates the strong impact of the pulsation and of the liquid flow rate during the impulsion to reduce the particles segregation inside the pilot. The effects of operating parameters on the liquid phase are also investigated and the choice of an operating compromise is discussed to balance advantages and drawbacks on the process.
MIT Open Access Articles Online Embeddings

We initiate the study of on-line metric embeddings . In such an embedding we are given a sequence of n points X = x 1 , . , x n one by one, from a metric space M = ( X, D ) . Our goal is to compute a low-distortion embedding of M into some host space, which has to be constructed in an on-line fashion, so that the image of each x i depends only on x 1 , . , x i . We prove several results translating existing embeddings to the on-line setting, for the case of embedding into (cid:96) p spaces, and into distributions over ultrametrics.
An Investigation of the Impact of International Remittance on the Architectural Element of the Landscape of Isiala Nsulu Autonomous Community, Abia State, Nigeria

nternational money remittance is money and goods sent to origin of I remitters from their host countries. In the past twenty years, many rural and urban dwellers have migrated to Europe, United States and Asia and anywhere, but Nigeria, due to unemployment and poverty. This has seen our professionals leave in search of green pastures. Most of them lived in non-decent residences in the urban area in Nigeria before migrating and had no houses in their respective rural areas. Isiala Nsulu autonomous community is one of such committees whose youth migrated. Most of these migrants have been able to remit money and goods, which have been used in improving the lifestyle of their families, build new houses of exotic styles and in renovating the old. This study investigated how much their remittances have aﬀected the architectural element of the landscape of Isiala Nsulu autonomous community. The study got data from the families of 100 remitters and, the buildings they have commissioned as well as its values. It was discovered that 46% had built houses and that the buildings changed the very traditional architectural outlook of the communities. The study recommended that remitters invest in industrial and agricultural projects to help provide employment for youths and limit migration.
Dating a small impact crater: An age of Kaali crater (Estonia) based on charcoal emplaced within proximal ejecta

The estimates of the age of the Kaali impact structure (Saaremaa Island, Estonia) provided by different authors vary by as much as 6000 years, ranging from ~6400 to ~400 before current era (BCE). In this study, a new age is obtained based on 14C dating charred plant material within the proximal ejecta blanket, which makes it directly related to the impact structure, and not susceptible to potential reservoir effects. Our results show that the Kaali crater was most probably formed shortly after 1530–1450 BCE (3237 ± 10 14C yr BP). Saaremaa was already inhabited when the bolide hit the Earth, thus, the crater‐forming event was probably witnessed by humans. There is, however, no evidence that this event caused significant change in the material culture (e.g., known archeological artifacts) or patterns of human habitation on Saaremaa.
ISLAMIC MODE OF FINANCING: A PANACEA TO THE NIGERIA'S EXTERNAL DEBT BURDEN

From Paris to London Club, Nigeria looms into debt crisis as a result of inefficiencies in the current borrowing policies. Interest based borrowing policies put the country in the mess of debt crisis with very unbearable repercussions. For Nigeria to be free from this turmoil there is the need to change these policies to more appropriate and acceptable ones. The paper attempts to present an alternative way of financing, i
Synthetic modification of fusogenic coiled coil peptides

Peptide stapling is a technique which has been widely employed to constrain the conformation of peptides. One of the effects of such a constraint can be to modulate the interaction of the peptide with a binding partner. Here, a cysteine bis-alkylation stapling technique was applied to generate structurally isomeric peptide variants of a heterodimeric coiled-coil forming peptide. These stapled variants differed in the position and size of the formed macrocycle. C-terminal stapling showed the most significant changes in peptide structure and stability, with calorimetric binding analysis showing a significant reduction of binding entropy for stapled variants. This entropy reduction was dependent on crosslinker size and was accompanied by a change in binding enthalpy, illustrating the effects of preorganization. The stapled peptide, along with its binding partner, were subsequently employed as fusogens in a liposome model system. An increase in both lipid, and content-mixing was observed for one of the stapled peptide variants: this increased fusogenicity was attributed to increased coiled-coil binding but not to membrane affinity; an interaction theorized to be a primary driving force in this fusion system.
Effectiveness and safety of inactivated SARS-CoV2 vaccine (BBIBP-CorV) among healthcare workers: A seven-month follow-up study at �fteen hospitals

OBJECTIVE Health care workers_ the �rst line army in the current pandemic_ are the most vulnerable group for COVID-19 infection. Vaccination of health care workers is strongly recommended to salvage our army. However, more research is needed to determine the safest and most effective vaccine. In our study, we assessed the safety and effectiveness of the �rst approved vaccine in Egypt_ the Sinopharm vaccine.
Tectonic implications of transtensional supradetachment basin development in an extension‐parallel transfer zone: the Kocaçay Basin, western Anatolia, Turkey

The Kocaçay Basin (KÇB) is a key area in western Anatolia – a well‐known extended terrane where regional segmentation has received limited attention – for investigating strike‐slip faults kinematically linked to detachment faults. In this paper, we present results of an integrated sedimentologic, stratigraphic, and structural study of Miocene alluvial fan/fan‐delta/lacustrine deposits that accumulated in the KÇB, a NE‐trending basin with connections to the Menderes Metamorphic Core Complex (MCC). We mapped and evaluated most of the key faults in the KÇB, many for the first time, and recognised different deformation events in the study area near the E margin of the MCC. We also present field evidence for kinematic connections between low‐angle normal and strike‐slip faults which were developed in an intermittently active basement‐involved transfer zone in western Anatolia. We find that the KÇB contains a detailed record of Miocene transtensional sedimentation and volcanism that accompanied exhumation of the MCC. Structural data reveal that the basin was initially formed by transtension (D1 phase) and subsequently uplifted and deformed, probably as a result of early Pliocene wrench‐ to extension‐dominated deformation (D2 phase) overprinted by Plio‐Quaternary extensional tectonics (D3 phase). These results are consistent with progressive deformation wherein the axis of maximum extension remained in the horizontal plane but the intermediate and maximum shortening axes switched position in the vertical plane. Combining our results with published studies, we propose a new working hypothesis that the KÇB was a transtensional supradetachment basin during the Miocene. The hypothesis could provide new insights into intermittently active extension‐parallel zone of weakness in western Anatolia.These results also suggest that the termination of low‐angle normal fault systems within an extension parallel transfer zone may have resulted in a transtensional depressions which are different from classical supradetachment basins with respect to the sedimentation and deformational pattern of the basin infills.
Spatial patterns of provincial carbon source and sink in China

China has become the biggest country of carbon emissions, and the size and scale of industrialization and urbanization are unprecedented. The pressure of carbon reduction is increasing day by day with the increasing carbon emissions which have caused more and more international concerns. Carbon reduction should be made possible by both reducing carbon source and increasing carbon sink at the same time. Policies of low carbon development should be different to the regions with obviously different existing carbon source and carbon sink. In this paper, by collecting the data from the forest inventory and some related statistical yearbooks, and by applying the methods of discharge coefficient, stand volume, and carbon sequestration rate in forest and grassland ecosystems at region scale, we made an overall estimation of carbon emissions from energy consumption, and carbon sinks from forest, grassland and arable land at the provincial scale. Then, the regional differences of total carbon emissions, carbon emissions per capita, carbon emissions per unit area, and energy intensity in China are analyzed, and spatial pattern of carbon sink and carbon surplus are discussed. As to the overall carbon emissions at the provincial scale, the carbon emission in Shandong, Shanxi and Hebei is relatively high; the carbon emission in Ningxia, Qinghai and Hainan is relatively low. As to the per capita carbon emission, Inner Mongolia, Shanxi and Ningxia have the largest per capita carbon emission; Jiangxi, Hainan and Guangxi have the lowest. As to the carbon emission per square kilometer, Shanghai has the largest; Qinghai has the lowest. Besides, the provinces with relatively low carbon intensity are Beijing, Guangdong, Shanghai, and Zhejiang, etc. Nationwide, the percentage of forest carbon sink is 53%, and the percentage in Yunnan and Heilongjiang is relatively high. The percentage of grassland carbon sink is 38.51%, mainly concentrated in Inner Mongolia, Qinghai and Xinjiang province. The carbon sinks from arable land focus on the carbon in the process of Maize straw returning to the field, which account for 8.63% of the total carbon sink. The results show that the carbon sinks from arable land in Heilongjiang, Jilin, Henan and Liaoning are higher than the ones in other provinces. Combining the feature of carbon source and carbon sinks of the four economic zones, the key issues in low-carbon development are pointed out. In the future, eastern region should change the development mode and improve energy efficiency through technological innovations. Central region should seize the green development opportunity to promote the low-carbon industry to achieve leapfrog development. Northeast region has high carbon sinks and can actively participate in international carbon trading. By strengthening management, western region should accelerate the technological improvements to improve energy efficiency and the ecological environment, and to enhance the capacity of carbon sinks.
Cognitive Linguistics

Research has shown that it requires less time to process information that is part of an objective causal relation describing states of affairs in the world (She was out of breath because she was running), than information that is part of a subjective relation (She must have been in a hurry because she was running) expressing a claim or conclusion and a supporting argument. Representing subjectivity seems to require extra cognitive operations. In Mental Spaces Theory (MST; Fauconnier, Gilles. 1994. Mental spaces: Aspects of meaning construction in natural language. Cambridge: MIT Press) the difference between these two relation types can be described in terms of an extra mental space in the discourse representation of subjective relations: representing the Subject of Consciousness (SoC). In processing terms, this might imply that the processing difference is not present if this SoC has already been established in the discourse.We tested this prediction in two eye tracking experiments. The results of Experiment 1 showed that signaling the subjectivity of the relation by introducing a subject of consciousness beforehand did not diminish the processing asymmetry compared to a neutral context. However, the relative complexity of subjective relations was diminished in the context of Free Indirect Speech (No! He was absolutely sure. There was no doubt about it. She was running so she was in hurry; Experiment 2). In terms of MST and the representation of subjectivity in general, this implies that not only creating a representation of a thinking subject, but also assigning a claim to this thinking subject requires extra processing effort.
Eligibility, Utilization, and Effectiveness of 17-Alpha Hydroxyprogesterone Caproate in a Statewide Population-Based Cohort of Medicaid Enrollees

Objectives The primary objective was to estimate the initiation and adherence rates of 17 α -hydroxyprogesterone caproate (17OHPC) among eligible mothers in a statewide population-based cohort of Medicaid enrollees. The secondary objectives were to (1) determine the association of maternal sociodemographic and clinical characteristics with 17OHPC utilization and (2) assess the real-world effectiveness of 17OHPC on recurrent preterm birth prevention and admission to neonatal intensive care unit (NICU). Study Design This is a retrospective cohort study using a linked, longitudinal administrative dataset of birth certi ﬁ cates and medical assistance claims. Medicaid-enrolled mothers in Pennsylvania were included in this study if they had at least one singleton live birth from 2014 to 2016 following at least one spontaneous preterm birth. Maternal Medicaid claims were used to ascertain the use of 17OHPC