Miracle-dz/UniFAR-FTUs huggingface dataset:
Control Region Modules Within the Murine CD21 Intronic Repeating, Cyclosporin-Sensitive Regulatory Yin Yang and NFAT-4

The murine complement receptor type 2 gene ( Cr2/CD21 ) is expressed by murine B and follicular dendritic cells, but not murine T cells. We have previously shown that appropriate transcriptional control of the CD21 gene requires the CD21 promoter as well as intronic sequences. We have also demonstrated that altering chromatin structure by inhibiting histone deacetylases induces CD21 expression in murine T cells by increasing the accessibility of promoter and intronic regulatory elements. In this report, we identify seven distinct regulatory areas within the ﬁrst intron of the murine CD21 gene that are conserved between mouse and human CD21 intronic sequences. EMSA competition and supershift analyses reveal the formation of multiple DNA-protein complexes at these sites that include Yin Yang 1, Oct1, and NFAT-4. NFAT-containing complexes were altered in B cells treated with the NFAT inhibitor cyclosporin A and correlated with a repression of CD21 gene transcription implicating NFAT transcriptional control. Functional data revealed that no single region conferred cell-speciﬁc reporter gene expression, but rather the entire CD21 regulatory element was required to confer cell-speciﬁc gene expression. Taken together, these data demonstrate the formation of repeating, overlapping regulatory modules, all of which are required to coordinately control the cell-speciﬁc expression of the murine CD21 gene. We propose a model in which Yin Yang 1 and Oct1 may recruit histone deacetylase to multiple sites in the CD21 intronic regulatory element in nonexpressing cells and NFAT either displaces this histone deacetylase or recruits a histone acetylase to allow the formation of a functional transcriptional complex in expressing cells. The Journal of Immunology, 2002, 168: 3341–3350.
R?esolutions de foncteurs de Mackey

Used lubricating oils, particularly those containing additives such as V. I. improvers, dispersants and the like, are reclaimed by a preliminary treat with a C4 to C5 aliphatic alcohol, which causes the separation of a layer of sludge which contains polar additives and oxidation products. The desludged oil is then subjected to conventional lubricating oil refining steps such as treatment with fuming sulfuric acid followed by neutralizing, washing, and clay treating steps. Alternatively, the desludged oil is subjected to a hydrogenation treatment rather than the sulfuric acid treatment. Extraction with phenol, furfural, etc. can also be included, as well as redistillation or fractionation. Advantages over prior art oil reclaiming processes include higher yields of finished reclaimed oil, the formation of appreciably less byproduct sludge, and the obtaining of a more oxidation-resistant reclaimed oil.
Nest on the

During the 2006 and 2007 breeding seasons raptor nests were monitored on the Los Banos Wildlife Area Complex and on nearby private lands in Merced County, California. The survey focused on the nesting success of three primary raptor species: Red-tailed Hawk ( Buteo jamaicensis ), Swainson’s Hawk ( Buteo swainsoni ), and Great Horned Owl ( Bubo virginianus ). Nests of these species were monitored to determine breeding success and productivity on Department of Fish & Game lands. Extra attention was given to nesting Swainson’s Hawks due its listing as a California threatened species. Monitoring of the Swainson’s Hawk, as well as all nesting raptors, has occurred on the Los Banos Wildlife Area Complex since 2001. There were 59 monitored raptor nests in 2006 and 54 monitored raptor nests in 2007. Though there were similar numbers of Swainson’s Hawk nests monitored, the nesting success was much higher in 2006 (59%) than in 2007 (39%). Climatic conditions early in the Swainson’s Hawks’ breeding season are suspected as the primary cause for the reduction in nesting success. It is indeterminable if nesting success is higher on the surrounding public land than on the Los Banos Wildlife Area Complex based on the collected data.
Interface study of FeMgOFe magnetic tunnel junctions using 3D Atom Probe

A detailed interface study was conducted on a Fe/MgO/Fe system using laser assisted 3D atom probe. It exhibits an additional oxide formation at the second interface of the multilayer structure independent of laser wavelength, laser fluence and the thickness of the tunnel barrier. We have shown with the help of simulation that this phenomena is caused by the field evaporation of two layers having two different evaporation
COPD_A_290714 2755..2767

1Kaiser Permanente Center for Health Research, Science Programs Department, Portland, OR, USA; 2GlaxoSmithKline, US Value Evidence and Outcomes, Research Triangle Park, Durham, NC, USA Background: There is currently little research describing patient experience and continuity of care immediately prior, during, and following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This analysis examined clinical characteristics, chronic obstructive pulmonary disease (COPD)-related medication patterns and outpatient visits before and after an AECOPD. Methods: This retrospective analysis used electronic health records, medical claims, and pharmacy dispensing data for patients within the Kaiser Permanente Northwest Health System. Patients with ≥1 AECOPD between January 1, 2015 and December 31, 2017 were identified. The most recent AECOPD was considered the index date. An AECOPD was defined as an inpatient hospitalization with a primary diagnosis of COPD, or respiratory failure with a secondary diagnosis of COPD, or an outpatient visit with a primary diagnosis of COPD and dispensing of respiratory-related antibiotics and/or oral corticosteroids ±5 days of the visit. Eligible patients were: ≥40 years old; ≥2 encounters within 12 months of each other or ≥1 hospitalization with primary or secondary COPD diagnosis, chronic bronchitis, or emphysema prior to index; and continuously enrolled ±90 days relative to index. COPDrelated inhaled maintenance medication, rescue inhalers, oral corticosteroid use, and ambulatory visits were assessed 90-days preand post-index. Results: There were 2829 patients included (mean [standard deviation] age: 69.0 [10.5] years) who had an AECOPD (7% severe; 93% moderate). The percentage of patients on inhaled maintenance therapy increased from 60.6% pre-AECOPD to 68.8% post-AECOPD and increased from 60.0% to 87.4% among patients who experienced a severe AECOPD. COPD-related ambulatory visits increased more than four-fold for primary care and more than doubled for pulmonologist visits in the post-AECOPD period. Conclusion: The low proportion of patients observed with changes to controller and rescue medication (particularly following a moderate AECOPD), yet higher utilization of COPDrelated ambulatory visits before and after an AECOPD suggests that there is opportunity to improve pharmacotherapy management.
Comparison of Assay Results by Two Methods, Urea on Cobas 6000 (Fully Automated Clinical Chemistry Analyzer) and Dirui DR-7000D (Semi-Automated Clinical Chemistry Analyzer)

Background: In different parts of Ethiopia, one laboratory may own more than one diagnostic device or reagent kit measuring the same analyte (around 42 different Clinical Chemistry analyzers throughout the country) and this situation causes great troubles for quality control and traceability. Therefore, a comparison of any two-assay results done by two different methods is of great importance in a clinical laboratory. Objective: To compare the assay result of Urea on Dirui DR-7000D and Cobas 6000 chemistry analyzers. Methods: Prospective cross-sectional study design was conducted at Addis Ababa University (AAU) and Ethiopian Public Health Institute (EPHI) in 2019. The collection of data was done with the data collection format prepared by the principal investigator containing Test method, Comparative Method and Urea test result by using convenience sampling technique from April 01-10/2019.The data was cleaned, edited, checked for completeness and entered into SPSS version 23 for analysis. The Clinical and Laboratory Standards Institute (CLSI) document EP9-A2 guidelines were followed to evaluate the method comparison using 46 patient samples. The result was presented with tables and figures accordingly. Results: Comparing Dirui DR-7000D (Semi-automated chemistry analyzer) and Cobas 6000 (Fully automated chemistry analyzer) for urea assay test result the regression parameter R2=0.814, Slope=0.48, intercept=15.15 was found. More importantly, Bland-Altman plots indicated that a positive bias (mean ± SD) was observed: Urea (3.1315 ± 9.655685 mg/dL). Conclusion: Statistically Significant differences between two Chemistry analyzers (Dirui DR-7000D and Cobas 6000) at p value <0.01 were found. Even though, the difference found was statistically Significant, it is impossible to conclude that the two machines has no strong positive correlation due to some limitations of the study. To reach conclusion further experiment is needed by strictly following updated method comparison guidelines.
Overconfidence bias, Financial Literacy and Investment Decisions; moderation approach; a reflection from Small and Micro Enterprises in Nairobi County, Kenya

This aimed aimed at determining moderating effect of financial literacy on the relationship between overconfidence bias and investment decisions among Small and Micro Enterprises. The study was anchored on competency theory. The study employed explanatory research design and positivist paradigm. The target population was 102,821 firm owners. A sample of 383 respondents was selected using stratified random sampling technique. The collected data was analysed using descriptive and inferential statistics. Findings from hierarchical linear regression revealed that financial literacy moderates the relationship between overconfidence and investment decisions (β = .42 >0.05, ∆ R 2 = .07). The study recommends that firms should improve on financial literacy which improves the relationship between behavioural factors and investment. There existed a very strong relationship between the two variables as a result of financial literacy. This would enhance better investment decision improving financial performance of the SMEs.
ArticleSex differences in the incidence and outcomes of acute myocardial infarction in Spain

(1) Background: Our aim was to analyze the incidence, procedures, and in-hospital outcomes of myocardial infarction (MI) in Spain (2016–2018) according to sex. (2) Methods: We estimated the incidence of an ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI) according to sex using the Spanish National Hospital Discharge Database. A matched-pair analysis was used. (3) Results: MI was coded in 156,826 patients aged ≥18 years (111,842 men and 44,984 women). Men showed higher incidence rates (205.0 vs. 77.8 per 100,000; p < 0.001; IRR = 2.81(95%CI:2.78–2.84)). After matching, the use of coronary artery by-pass grafting (CABG) (1.0% vs. 0.7%; p < 0.001) and percutaneous coronary intervention (PCI) (57.8% vs. 52.3%; p < 0.001) was higher among men with an STEMI, whereas the in-hospital mortality (IHM) remained higher among women (11.2% vs. 10.1%; p < 0.001). Likewise, CABG (1.9% vs. 3.3%; p < 0.001) and PCI (33.8% vs. 41.9%; p < 0.001) were less often used among women with an NSTEMI, but no sex-related differences were found in IHM. After adjusting for confounders, IHM was more than twofold higher for both men and women with an STEMI than those with an NSTEMI. Women with an STEMI had a 21% higher mortality risk than men (OR = 1.21(95%CI:1.13–1.29). (4) Conclusion: Men had higher incidence rates of MI than women. Women underwent invasive procedures less often and had a higher IHM when admitted for an STEMI.
Austin Journal of Pharmacology and Therapeutics Autism and Oxidative Stress Interventions: Impact on Autistic Behavior

Autism is an increasingly prevalent neurodevelopmental disorder in the United States, which relies on applied behavioral therapy as means of treatment. This disorder has been linked to increased levels of oxidative stress and lower anti-oxidant capacity. Metabolites in the interconnected transmethylation and transsulfuration pathways are significantly altered in autism, causing decreased glutathione synthesis. This review article was performed to support the role of oxidative stress in autism and its clinical symptoms. The use of the glutathione redox ratio as a biomarker for disease and treatment status was supported. Anti-oxidant supplementation, or ways to improve the altered metabolite levels in the interconnected pathways, has been associated with decreased autistic behaviors and severity. These interventions should be further studied in order to determine their effectiveness at improving metabolic imbalances in Autism Spectrum Disorder (ASD). Overall, oxidative stress related metabolites could have potential use as biomarkers and help determine treatments.
COMPARATIVE EFFICACY OF FOUR FORMULATIONS BASED ON AROMATIC PLANT EXTRACTS AND A SYNTHETIC FUNGICIDE AGAINST Mycosphaerella fijiensis MORELET CAUSAL AGENT OF BLACK LEAF STREAK DISEASE (BLSD), IN INDUSTRIAL DESSERT BANANA

Silué Ténéna, Amari Ler-N’Ogn Dadé Georges Elisée, Tuo Seydou, Kassi Koffi Fernand Jean-Martial, Silué Nakpalo, Camara Brahima and Koné Daouda Teaching and Research Unit on Plant Physiology and Pathologies, Laboratory of Biotechnology, Agriculture and Development of Biological Ressources, Department of Biosciences, University Félix Houphouët -Boigny, 22 P.O Box 582 Abidjan 22, Côte d’Ivoire. Manuscript Info Abstract . Manuscript History Received: 25 December 2021 Final Accepted: 30 January 2022 Published: February 2022
Mate limitation in sea lice infesting wild salmon hosts: the influence of parasite sex ratio and aggregation

Mate limitation in dioecious parasite species has the potential to impact parasite population growth. Our focus of interest was the influence of parasite sex distribution among hosts on parasite reproduction and transmission dynamics for populations of ectoparasitic sea lice (Lepeophtheirus salmonis Krøyer) establishing on wild juvenile salmon hosts. The data included more than 139,000 out-migrating juvenile pink salmon (Oncorhynchus gorbuscha (Walbaum)) and chum salmon (Oncorhynchus keta (Walbaum)) in British Columbia, Canada, sampled over nine years. For almost all years, the sex ratio of the reproductive stages of the sea lice was female-biased. The probability of a female being able to mate (i.e., of being attached to a fish also carrying a male louse) increased with increasing parasite abundance and parasite aggregation. We compared, with expected modeling predictions, the observed prevalence of pairs of sea lice (i.e., one reproductive louse of each sex) on a given fish and the observed probability of a female being able to mate. These comparisons showed that male and female sea lice tend to be distributed together rather than separately on hosts. Distribution together means that sea lice are distributed randomly on hosts according to a common negative binomial distribution, whereas distribution separately means that males are distributed according to a negative binomial and females are distributed in their own negative binomial among hosts. Despite the tendency for distribution together we found that, in every year, at least 30% of reproductive female sea lice experience mate limitation. This Allee effect will result in submaximal rates of parasite reproduction at low parasite abundances and may limit parasite transmission. The work has important implications for salmon parasite management and the health both of captive farm salmon populations and migratory wild stocks. More broadly, these results demonstrate the potential impact of mate limitation as a constraint to the establishment and spread of wild ectoparasite populations.
Mixed Lymphocyte Responses CD1d-Reactive T Cells That Can Suppress Bone Marrow Lymphocytes Are Th2-Like Cutting Edge: A Major Fraction of Human

Murine bone marrow (BM) NK T cells can suppress graft-vs-host disease, transplant rejection, and MLRs. Human BM contains T cells with similar potential. Human BM was enriched for NK T cells, (cid:1) 50% of which recognized the nonpolymorphic CD1d molecule. In contrast to the well-characterized blood-derived CD1d-reactive invariant NK T cells, the majority of human BM CD1d-reactive T cells used diverse TCR. Healthy donor invariant NK T cells rapidly produce large amounts of IL-4 and IFN- (cid:1) and can inﬂuence Th1/Th2 decision-making. Healthy donor BM CD1d-reactive T cells were Th2-biased and suppressed MLR and, un-like the former, responded preferentially to CD1d (cid:2) lymphoid cells. These results identify a novel population of human T cells which may contribute to B cell development and/or maintain Th2 bias against autoimmune T cell responses against new B cell Ag receptors. Distinct CD1d-reactive T cell populations have the potential to suppress graft-vs-host disease and stimulate antitumor responses. The Journal of Immunology, 2001, 167: 5531–5534. Functional analysis of CD1d reactivity was performed as described (5, 7, 32), with invariant NK T cell lines or clones as controls. Inhibition of two-way MLR by BM T cells was performed similarly to that previously described (25, 26). Brieﬂy, 1 (cid:6) 10 5 PBMC each from two donors for each assay were mixed with equal numbers of CD1d-reactive BM T cells or controls for 5 days. Proliferation and cytokine measurements were per- formed as previously (5, 7, 32). All results are shown with SD.
Having it Both Ways: A Theory of the Banking Firm with Time-Consistent and Time-Inconsistent Depositors

Our equilibrium model determines the liquidity premium offered by a monopolistic bank to a pool of depositors made up of time-consistent and timeinconsistent agents. Time-consistent depositors demand compensation for illiquidity, whereas time-inconsistent ones are willing to forgo interest on illiquid savings accounts to discipline their future selves. We show that formal financial markets can reward time-inconsistent clients for illiquidity, even though these agents would agree to pay for it. The explanation combines two factors: the existence of reserve requirements making the bank keen to reward illiquid accounts more than liquid ones, and the presence of time-consistent agents who view illiquidity as a burden and therefore demand compensation for holding illiquid accounts.
The largeN-terminal domainofCdc25protein oftheyeast Saccharomyces cerevisiae is required forglucose-induced Ras2activation

The Saccharomyces cerevisiae CDC25 gene encodes a guanine nucleotide exchange factor for Ras proteins whose catalytic domain is highly homologous to Rasguanine nucleotide exchange factors from higher eukaryotes. In this study, glucose-induced Ras activation and cAMP response were investigated in mutants lacking the N-terminal domain of Cdc25 or where the entire CDC25 coding sequence was substituted by an expression cassette for a mammalian guanine nucleotide exchange factor catalytic domain. Our results suggest that an unregulated, low Ras guanine nucleotide exchange factor activity allows a normal glucoseinduced cAMP signal that appears to be mediated mainly by the Gpr1/Gpa2 system, but it was not enough to sustain the glucose-induced increase of Ras2-GTP normally observed in a wild-type strain.
Modeling the Iowa Gambling Task 1 Running head: MODELING THE IOWA GAMBLING TASK Bayesian Parameter Estimation in the Expectancy Valence Model of the Iowa Gambling Task

The purpose of the popular Iowa gambling task is to study decision making deficits in clinical populations by mimicking real–life decision making in an experimental context. Busemeyer and Stout (2002) proposed an “Expectancy Valence” reinforcement learning model that estimates three latent components which are assumed to jointly determine choice behavior in the Iowa gambling task: weighing of wins versus losses, memory for past payoffs, and response consistency. In this article we explore the statistical properties of the Expectancy Valence model. We first demonstrate the difficulty of applying the model on the level of a single participant, we then propose and implement a Bayesian hierarchical estimation procedure to coherently combine information from different participants, and we finally apply the Bayesian estimation procedure to data from an experiment designed to provide a test of specific influence.
Care for an elderly person after lower limb amputation

Introduction: Although currently less major amputation is performed, due to more effective revascularization and endovascular treatment, limbs amputations are still necessary and commonly used as a therapeutic method. Amputation of the lower limb is associated with long-term hospitalization, treatment, rehabilitation and a high level of mortality among older people. For the elderly, additionally suffer from number of chronic diseases, who for various reasons amputation of the limb is the only possible treatment option, recommendations regarding further care after such surgery are important. Results: Causes of lower limb amputation include ia. non-traumatic reasons like diabetes or infection and traumatic ones. Frequency of removal of the lower limb, regardless of its reason is estimated about 5.6 to 600 per 100,000 people and the percentage is about 20 times higher in diabetes-suffering people than in non-diabetic. In the case of this disease, amputations mainly concern men over 60 years of age, as well as people who have been subject to hospital treatment many times. Care for a patient who is prepared to amputation procedure include pre- and post-operative rehabilitation, prosthesis of amputated limb, psychological care, patient education and also pharmacotherapy. It is important to give to patient enoxaparin to reduce thromboembolic risk. To increase quality of life after amputation it is important to provide adequate nursing care. Discussion: Other overlooked diseases, which can lead to lower limb amputation are ia. Charcot disease. Proper diagnosis, differentiation and treatment process is extremely important cause can allow patient to avoid the amputation. Conclusion: Gathered recommendations for correct, high-quality, multi-faceted medical care for patients after amputation of the lower limb will improve the quality of medical services for this group of patients.
Antimicrobial effect of bacteriocin from Lactobacillus fermentum isolated from goat milk on perishable foods. San Luis. Argentina

Strain selected for this study was isolated and named as sl36, from samples of goat milk collected from stainless steel drums in a dairy farm (San Luis, Argentina). The LAB strain was biochemically typified as Lactobacillus fermentum and designated as L. fermentum sl36. This identification was confirmed by 16S rRNA full sequences. The selected strain showed antimicrobial activity against food-borne pathogens, Listeria monocytogenes, Listeria innocua, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. The inhibitory activity was lost after treatment with trypsin, which indicates that this activity is due to a protein nature substance compatible with bacteriocins produced by Gram positive bacteria.The inhibitory substance was stable at different pH and temperatures. Perishable food samples (semi-hard cheese, cream, cooked pork shoulder) were treated with cell free supernatant from studied strain and then with indicator S. aureus and E. faecalis bacteria suspensions. Lactobacillus fermentum sl36 caused the inhibition of the growth of E. faecalis and S. aureus in the treated foods. Our work shows that it is possible to increase the safety of food perishable directly using the bacteriocins produced by the LAB strains, difference from the more frequent practice of using the bacteria themselves as probiotics. Keywords— Antimicrobial activity, goat milk, Lactic Acid Bacteria, Lactobacillus fermentum, perishable foods.