Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence and Trends of Developmental Disabilities among Children in the US: 2009-2017

Objective— To study the national prevalence of ten developmental disabilities in US children aged 3–17 years and explore changes over time by associated demographic and socioeconomic characteristics using the 2009–2017 National Health Interview Survey (NHIS). Methods— Data come from the NHIS, a nationally-representative survey of the civilian noninstitutionalized population. Parents reported physician or other health care professional diagnoses of attention-deficit/hyperactivity disorder (ADHD); autism spectrum disorder (ASD); blindness; cerebral palsy; moderate to profound hearing loss; learning disability (LD); intellectual disability (ID); seizures; stuttering or stammering; and other developmental delays. Weighted percentages for each of the selected developmental disabilities and any developmental disability were calculated between 2009–2017 and stratified by selected demographic/socioeconomic characteristics. Results— From 2009–2011 to 2015–2017, there were overall significant increases in the prevalence of any developmental disability (16.2% to 17.8%, p<.001), ADHD (8.5% to 9.5%, p<.01), ASD (1.1% to 2.5%, p<.001), and ID (0.9% to 1.2%, p<.05), but a significant decrease for any other developmental delay (4.7% to 4.1%, p<.05). The prevalence of any developmental disability increased among boys, children ages 12–17, non-Hispanic white and Hispanic children, This study presents new nationally representative data on the prevalence of developmental disability, recent demographic trends, and estimates by urban or rural residence.
Correlation and path analysis studies in aromatic rice germplasm of North-East region of India

An experiment was conducted in research fields of the department of Genetics and Plant Breeding, College of Agriculture, CAU, Imphal to study the nature and degree of association between yield and its component characters and their direct and indirect effects on grain yield in aromatic rice genotypes of North east region of India. Among the important characters studied no. of grains per plant, no. of panicles per plant, 1000 grains weight, panicle length and plant height showed high significant positive correlation with grain yield per plant. Maximum direct effect on grain yield was also observed from no. of grains yield per plant followed by no. of panicles per plant, panicle length, plant height and 1000 grains weight.
Physiological effects of water extract from Flaveria bidentis on wheat seedlings.

In order to identify the effects of Flaveria bidentis,a invasive plant grown in Hengshui Lake,on physiological characteristics of wheat seedling and provide a basis for the scientific management of wheat.Wheat seedlings were treated with different concentration of the water extract from F.bidentis root and stem + leaf.Then the root vigor,membrane permeability,activities of SOD,POD and CAT,and the content of MDA of wheat seedlings were determined and the allelopathic effect was investigated.The results indicated that the root vigor,activities of SOD,POD and CAT decreased with the increase of the extract concentration,but the membrane penetrability and the content of MDA increased progressively,which indicated that the water extract from F.bidentis had negative effects on physiological characteristics of wheat seedlings.The influence of lower concentration was relatively smaller.As to the rate of inhibiting(RI) and synthetic inhibiting effects(SE),the allelopathic inhibition of F.bidentis stem + leaf extracts was stronger than that of root.
Christopher J. WardYanhong WuRuth A. JohnsonJohn R. WoollardEric J. BergstralhMine S. Cicek • Jason BakebergSandro RossettiChristina M. HeyerGloria M. PetersenNoralene M. Lindor • Stephen N. ThibodeauPeter C. HarrisVicente E. TorresMarie C. HoganLisa A. Boardman

The autosomal recessive polycystic kidney disease (ARPKD) gene, PKHD1, has been implicated in the genesis or growth of colorectal adenocarcinoma, as a high level of somatic mutations was found in colorectal tumor tissue. To determine whether carriers of a single PKHD1 mutation are at increased risk of colorectal carci- noma, we assessed the prevalence of the commonest European mutation, T36M. First, we assayed a European cohort of ARPKD patients and found T36M was responsible for 13.1% of mutations. We then investigated two European cohorts with colorectal adenocarcinoma versus two control cohorts of similar age and gender. Screening for the most common PKHD1 mutation, T36M, we detected 15:3,603 (0.42%) controls versus 1:3,767 (0.027%) colorectal cancer individuals, indicating that heterozygous PKHD1 mutations are not ar isk factor and are protective (p = 0.0002). We also show that the carriage rate for PKHD1 mutations in the European population is higher than previous accepted at 3.2% (1:31 genomes).
Auditors’ Responses to Asset Redeployability

This study shows that auditors are more likely to charge higher audit fees, issue false-positive going concern opinions (i.e., Type I error), and resign from high asset redeployability (AR) firms. In supplemental tests, we use path analysis to show that the significant associations between AR and auditor responses can be explained by higher inherent risk (earnings management and abnormal asset sales) and audit business risk (misstatements and litigation risk). Collectively, our results suggest that auditors tend to react conservatively when firms are associated with high AR.
Work-Life Conflict and Organizational Commitment: A Study Of Female Faculty In Higher Education

This study was conducted to discover the impact of work-life conflict on organizational commitment of female faculty at private universities in Karachi, Pakistan. To test association between the two variables, correlation was used. The results were further corroborated by the use of contingency table. The target population was permanently employed female faculty of private universities. The study was done through interviews and questionnaire survey. The method employed for this purpose wast-test of correlation and chi-square test of association. The study revealed that faculty members at private universities in Karachi had time-based conflict but they did not have strain-based and behaviour-based Conflict. The female faculty were committed to their organizations and the affective commitment showed higher result than continuance and normative commitment. The study reveals that there exists a weak association between two critical variables i.e. work-life conflicts and organizational commitment.
Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions*

α-Synuclein is one of the major components of intracellular fibrillary aggregates in the brains of a subset of neurodegenerative disorders, including Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and Hallervorden-Spatz disease, which are referred to as α-synucleinopathies. We have shown previously (Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., and Iwatsubo, T. (2002) Nat. Cell Biol. 4, 160–164) that α-synuclein deposited in synucleinopathy brains is extensively phosphorylated at Ser-129 and migrates at 15 kDa. Here we examined the biochemical characteristics of the additional, higher molecular mass species of phosphorylated α-synuclein-positive polypeptides that also are recovered in the Sarkosyl-insoluble fraction of synucleinopathy and migrate at about 22 and 29 kDa. These 22 and 29 kDa bands were positive for three different anti-ubiquitin antibodies and comigrated perfectly with in vitro ubiquitinated α-synuclein that may correspond to mono- and diubiquitinated α-synuclein, respectively. Furthermore, cyanogen bromide cleavage of the 22 and 29 kDa polypeptides shifted the mobility to 19 and 26 kDa, respectively, and they retained immunoreactivity for both ubiquitin and α-synuclein. Finally, protein sequence analysis showed that the 19 kDa band contained two amino-terminal sequences of α-synuclein and ubiquitin. These results strongly suggest that phosphorylated α-synuclein is targeted to mono- and diubiquitination in synucleinopathy brains, which may have implications for mechanisms of these diseases.
Modulating Effects of Whole-body Vibration on Cortical Activity and Gait Function in Chronic Stroke Patients

Whole-body vibration exercise (WBVe) can provide proper somatosensory stimulation and improve muscle strength in stroke patients. This study investigated the effects of WBVe on gait function and cortical activity in patients with chronic stroke. Thirty stroke patients were randomly assigned to either the WBVe or the control group. The WBVe group received the vibration in a half-squat position for 5 minutes at an intensity of 20 Hz. The control group kept the same posture but did not receive the vibration. Cortical activity was investigated using functional near-infrared spectroscopy (fNIRS). Gait function was assessed by a 10-m walk test (10MWT), a timed up and go (TUG) test, a Fugl-Meyer Assessment, and a Tinetti Performance-Oriented Mobility Assessment (TPOMA). In group analysis of the fNIRS data, oxygenated hemoglobin concentration was significantly increased in the ipsilesional supplementary motor area, bilateral sensorimotor cortex, and contralesional prefrontal cortex in the WBVe group compared to the control group (p < 0.05). Functional assessment demonstrated a significant interaction between time and group for the 10MWT and TUG test, suggesting that the WBVe group demonstrated meaningful improvement after intervention (p < 0.05). These results suggested that WBVe modulated the cerebral cortical activities and resulted in improvement of gait function in chronic stroke patients. Trial Registration ClinicalTrials.gov Identifier: NCT03375346
Incidence of Urinary Tract Infection, Identification of Pathogen and Drug Sensitivity Pattern in Children with Nephrotic Syndrome

Introduction: Nephrotic syndrome is primarily a pediatric disorder and it affects 1-3 per 100,000 children <16 years of age. The prevalence of UTI is high in nephrotic syndrome patients.UTI may be responsible for poor response to steroid therapy and it also induces relapses. Objectives: To determine the incidence of urinary tract infection, identifications of pathogen and antibiotic sensitivity pattern of UTI in children with nephrotic syndrome. Method: All nephrotic syndrome patients attending the OPD or Indoor who are fulfilling the criteria were included in the study. Detailed history was taken. Routine tests including the urine culture sensitivity were sent. Result: Incidence of UTI among nephrotic syndrome patients was18.75%. E.coli, Enterococcus, Klebsiella sp. , Acinetobacter was the organisms. Commonest organism found was E.coli. Aminoglycoside group of drugs found to be the most sensitive (100%) followed by third generation cephalosporin (80%). Conclusion: UTI is not at all uncommon in nephrotic syndrome patients and all the patients may not present with classical symptoms. Hence a high degree of suspicion is essential for early diagnosis.
RNA Synthetic Biology using the Hammerhead Ribozyme : Engineering of Artificial Genetic Switches

(2014) Ribozyme-based aminoglycoside switches of gene expression engineered by genetic selection in S. cerevisiae, ACS synthetic biology. Engineering of ribozyme-based aminoglycoside switches of gene expression by in vivo genetic selection in Saccharomyces cerevisiae, Methods Enzymology 550, 301-20. Screening of genetic aptazyme switches for conditional gene expression using a mammalian cellular system, notwendigen Rückhalt gegeben, meine Ziele zu erreichen.
Rediscovering the CCAPM Lost in Data Revisions

The CCAPM has significant explanatory power for cross-sectional expected stock returns when we use \emph{real-time} consumption, in contrast with poor performance of \emph{revised} latest-vintage consumption documented in previous studies. The Bureau of Economic Analysis smooths consumption data gradually through data revisions. Data smoothing introduces future information to the estimation and makes latest-vintage consumption a poor measure of systematic risk. Our calibration of a stylized model shows that a substantial degree of smoothing is needed to account for key moments of both real-time and revised consumption.
Transcriptional and post-transcriptional regulation in testicular toxicity

i ACKNOWLEDGEMENT ii CONTENTS iii LIST OF TABLES ix LIST OF FIGURES xi LIST OF FORMULAE xiv LIST OF ABBREVIATIONS xv CHAPTER 1: INTRODUCTION 1 1.1. GENERAL INTRODUCTION 1 1.2. MALE REPRODUCTIVE SYSTEM 1 1.2.1. Testis 2 1.2.2. Testis function 3 1.2.3. Epididymis 5 1.3. MOLECULAR REGULATION 5 1.3. 1. Gene expression 5 1.3. 1.2. Gene expression during spermatogenesis 9 1.3. 2. Regulation of gene expression during spermatogenesis 11 1.3. 2.1. Transcriptional regulation in the testis 11 1.3. 2.2. DNA methylation 14 1.3. 2.3. Histone modification 17 1.3. 2.4. miRNA expression 18 1.3. 2.5. Epigenetic dysregulation 21 1.4. TESTICULAR TOXICITY 22 1.4.1. Testicular toxicants 23 1.4.1.1. Dibutyl Pthalate 23 1.4.1.2. 17β-Estradiol 24 1.4.1.3. Doxorubicin 25 1.5. TESTICULAR TOXICITY TESTING 26 1.5. 1. Functional measurement 26 1.5. 1.1. Fertility 26 1.5. 1.2. Heritable genotoxicity 27 1.5. 2. Morphological assessment 27 1.5. 2.1. Organ weight 27 1.5. 2.2. Histology 28 1.5. 3. Clinical assessment 30 1.5. 4. Other methods of assessing testicular toxicity 30 1.5. 4.1. In vitro assessment 30 1.5. 4.2. Toxicogenomics 30 1.6. APPLICATION OF TOXICOGENOMICS IN MALE REPRODUCTIVE TOXICITY AND RISK ASSESSMENT 35 1.6. 1. Transgenerational Toxicology 36 1.6. 2. Safety evaluation of chemicals 36 1.7. Aims 39 CHAPTER 2: MATERIALS AND METHODS 40 2.1. IN VIVO WORK 40 2.1.1. Animal dosing 40 2.1.1.1. Dibutyl Phthalate and 17β-Estradiol treatment 40 2.1.1.2. Doxorubicin treatment 41 2.1.2. Termination and organ collection 41
Characterization of Pro-embryogenic Calli and Somatic Embryogenesis of Byrsonima intermedia A. Juss.

Byrsonima intermedia A. Juss. is a species from the Brazilian Cerrado that produces edible fruits and, in common with other species from the Byrsonima genus, has pharmacological potential. Previous attempts to propagate the species through conventional methods showed difficulties. Thus, the purpose of this work was to characterize pro-embryogenic masses of Byrsonima intermedia callus, aiming for their in vitro propagation through somatic embryogenesis. Leaf segments from in vitro germinated seedlings were employed as explants for callus production. The calli were then subcultured and exposed to dyes to fulfill their embryogenic potential. Digitalizations of the cytological preparations were made in order to measure the area that was stained by both Aceto-Carmine and Evans-Blue, using image tool software. Somatic embryos were induced after treatments with 1-naphthaleneacetic acid (NAA). The percentages of double-colored areas (by Aceto-Carmine and Evans-Blue) were calculated and the data were analyzed by using the Skott-Knott test (P ≤ 0.05) and, the embryogenic callus, as well as the formation of somatic embryos were analyzed by using the Krsuskal-Wallis rank test (P ≤ 0.05). The results show that double coloration is effective at identifying cells showing embryogenic potential. Early callus subculture phases show a larger percentage of embryogenic area (83%). Somatic embryos were induced by using high auxin level.
Atividade alelopática de extratos de folhas de Schinus molle L. sobre a germinação e o crescimento inicial do rabanete

This study aimed to evaluate the allelopathic activity of leaf-soft mastic (Schinus molle L.) on germination and early growth of radish (Raphanus sativus L.). Leaf extracts were prepared at concentrations of 2, 4 and 8%. pH and osmotic potential were also performed from the extracts. Germination bioassay consisted of four replicates of 25 seeds of radish distributed in Petri dishes with germitest paper and 7 mL of extract or water and kept at 25 ° C in B.O. D. for five days. Germination percentage (PG), germination rate (VG), germination speed index (IVG) and Index of allelopathic effect (RI) were determined. For bioassay initial growth, seeds were germinated (2mm protrusion of radicle) and transferred to Gerbox contained germitest paper and 15 mL of extract or water, staying seven days at 25 ° C in B.O. D. to evaluate the length of radicle and hypocotyl, mass fresh and dry, the water content and content of chlorophyll (a, b and total). Extracts of leaves S. molle affected negatively all parameters examined for germination (PG, VG, IVG and RI). For the initial growth, the extracts caused a reduction of radicle length and stimulated the growth of hypocotyl. The extracts also led to increased the fresh and dry weight but did not alter the content of chlorophyll. Thus, as the pH and osmotic potential did not affect the results, S. molle exerted allelopathic effect on radish.
Institutional Trading around Firms’ Negative ESG Incidents

Using transaction-level institutional trades and a firm’s negative ESG incidents, we find<br>that institutional investors adjust their order flow prior to these non-financial events. <br>First, their trading is in the same direction of post-event cumulative abnormal returns<br>and results in abnormal profits. Second, the relationship between institutional order<br>flow and the subsequent abnormal return is also influenced by the firm’s existing CSR<br>score, and their trading in high-CSR firms lead to significant profit attenuation. These<br>findings suggest that institutional investors’ trading decisions are driven by financial<br>as well as social incentives. We conduct further analysis on firm-level information<br>asymmetry and shareholder breadth to identify their information advantage for their<br>profits. A subsample analysis reveals that institutional order flow is negatively related<br>to their preference for social responsible investment measured by the institution-level<br>CSR index.
DESEMPENHO VEGETATIVO E QUALITATIVO DO SORGO FORRAGEIRO (Sorghum bicolor X Sorghum sudanense) EM MANEJO DE CORTES

O objetivo foi estudar o efeito associativo entre hibridos de sorgo forrageiro ( Sorghum bicolor x Sorghum sudanense ): AG-2501C; XBS-79001; P-855F e BRS-800 e periodo de avaliacao durante o ciclo vegetativo da cultura (40, 75, 110 e 145 dias apos plantio), sobre o desempenho vegetativo produtivo e qualitativo da planta em manejo de cortes. O delineamento experimental foi o de blocos inteiramente casualizados com quatro repeticoes, num esquema fatorial 4x4. Os fatores hibrido e data de avaliacao interagiram (P > 0,05 ) sobre a producao de materia seca, participacao de colmo e de folhas na planta, teores de materia seca, de proteina bruta e de fibra em detergente neutro da planta inteira e dos componentes colmo e folhas. Nao houve interacao ( P
Common Variants in IGF2BP2 Gene rs4402960 and rs1470579 Polymorphisms Associate with Type 2 Diabetes Mellitus in Egyptians: A Replication Study

Genome-wide association studies identified novel genes associated with T2DM which have been replicated in different ethnic populations and yielded inconsistent results. Our study aimed to replicate in Egyptian population the identified association of insulin growth factor 2 m-RNA binding protein 2 (IGF2BP2) genetic variants rs4402960 and rs1470579 with T2DM. Our study included 120 unrelated T2DM patients and 128 control subjects who were genotyped by real-time polymerase chain reaction (real-time PCR). For rs1470579, the variant C allele was associated with T2DM (p<0.001). The frequency of (A/C + C/C) genotypes vs. A/A genotype was significantly higher in T2DM patients than in controls (70% vs. 30% and 37.5% vs. 62.5%, respectively) (p=0.00001). For rs440960, the variant T allele was associated with T2DM (p<0.001). Genotype G/G was the most frequent in controls (62.5%). The frequency of (G/T + T/T) genotypes vs. G/G genotype was significantly higher in T2DM patients than in controls (65.5% vs. 34.5% and 37.5% vs. 62.5%, respectively), (p=0.00001). These associations remained significant under all genetic models and after adjustment for covariates: gender, BMI, TGs and HDL-c. Both SNPs were in strong LD (D′ = 0.99 and r2 =0.98). Taking the common GA haplotype as reference, TC was the most frequent haplotype in T2DM patients and strongly associated with the disease (p = 0.004, OR= 3.29, 95%CI = 2.19–10.84), followed by GC haplotype (p = 0.02, OR=1.42, 95% CI=1.08–1.88) then the TA haplotype (P= 0.04, OR=1.14, 95%CI=0.99–1.86). In conclusion, IGF2BP2 susceptibility variants rs4402960 and rs1470579 associate with T2DM in Egyptians.
Obesity and Diabetes Mellitus as Predictors of Mortality in Patients with Stroke: A Meta Analysis

Background: Stroke is the leading cause of death and disability throughout the world. Based on studies in the United States (US), a person experiences a stroke every 40 seconds and every 4 minutes someone dies. The problem of comorbidity or the presence of more than one disease is the risk of stroke. This causes a person with comorbidities to have a higher risk of mortality than stroke patients without comorbidities. This study aims to examine the effect of obesity and diabetes mellitus as predictors of mortality in stroke patients. Subjects and Method: This was a meta-analysis and systematic review. The articles were obtained from Google Scholar, PubMed, Springer Link, Clinical key, and ProQuest databases. The articles have been published from 2010-2019. Keywords to search for articles are as follows: "comorbidity and stroke", "comorbidity and mortality and stroke and cross sectional study", "comorbidity and mortality and stroke and adjusted odd ratio", "comorbidity or stroke", "comorbi­dity or mortality or stroke or cross sectional study ", "comorbidity or mortality or stroke or adjusted odd ratio". The articles studied are full text articles with observational study design. Articles are collected using PRISMA diagram, and analyzed using the Review Manager application 5.3. Results: Obesity (aOR = 1.51; 95% CI = 1.03 to 2.21; p = 0.030) and diabetes mellitus (aOR = 1.75; 95% CI = 1.33 to 2.29; p <0.001) are predictors of mortality in stroke patients. Conclusion : Obesity and diabetes mellitus are predictors of mortality in stroke patients. Keywords : obesity, diabetes mellitus, stroke Cor r espondence: Karlinda. Masters Program in Public Health Sciences, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: karlindalinda8@gmail.com. Mobile: +6282278924093 Indonesian Journal of Medicine (2019), 4(4): 383-393 https://doi.org/10.26911/theijmed.2019. 04.04. 12