Miracle-dz/UniFAR-FTUs huggingface dataset:
Can Cardiometabolic Risk Be Reduced in the Elderly? Comprehensive Epidemiological Study

Through these epidemiological studies, which are based on statistical and observational calculations, without visual appeal, we tracked the incidence of public health problems. In this study, our research objective was to determine and evaluate the health patterns present in a population, along with identifying the factors that contribute to the risks or provide protection against specific diseases or conditions. The progression of cardiometabolic diseases is closely linked to various chronic conditions, such as diabetes, hypertension, dyslipidemia, and chronic kidney disease. This research study involved 578 patients, who were divided into six-year cohorts ranging from 2017 to 2022. The study examined parameters related to cardiometabolic diseases, including alcoholic hepatopathies, non-alcoholic hepatopathy, chronic kidney disease, hypertension, myocardial infarction, other forms of chronic coronary syndrome, peripheral vascular disease, microvascular diseases, macrovascular diseases, and hypercholesterolemia, while considering age and physical activity levels. The study concluded that individuals in the age group of 41–50 years exhibited the highest propensity for cardiometabolic damage. Additionally, the promotion of a healthy and active lifestyle is increasingly gaining traction among elderly patients.
The present status of high-Tc superconducting terahertz emitters

A terahertz (THz) wave emitter using the stack of intrinsic Josephson junctions present in the high-Tc superconductor Bi2Sr2CaCu2O8+δ (Bi2212) has been developed. By applying a dc voltage V across the stack, the ac-Josephson effect converts this to an ac-current that emits photons at the Josephson frequency proportional to V. The Bi2212 device also behaves as and electromagnetic (EM) cavity, so depending upon the shape of the Bi2212 crystal, when the Josephson frequency matches that of a cavity resonance, the emission power is enhanced. However, the EM radiation characteristics also strongly depend upon the effects of Joule self heating of the device. In order to alleviate this Joule heating problem, we fabricated three distinct stand-alone Bi2212 sandwich device shapes, each crystal being first covered with Au on its top and bottom, and then sandwiched between sapphire plates. From our comparative studies of the three devices, we obtained important clues that could help to increase the emission power up to ∼mW and the frequency range up to several THz, as necessary for many applications such as security screening, high speed communications, medical and biological sensing, and astronomical detection, etc.
Sweeteners’ Influence on In Vitro α-Glucosidase Inhibitory Activity, Cytotoxicity, Stability and In Vivo Bioavailability of the Anthocyanins from Lingonberry Jams

Several lines of evidence demonstrate the multiple health-promoting properties of anthocyanins, but little is known regarding the bioavailability of these phytochemicals. Therefore, the stability during storage and bioavailability of anthocyanins from lingonberries jams were determined by HPLC, together with the impact of used sweeteners on their adsorption. Further, the in vitro α-glucosidase inhibition using spectrophotometric methods and cytotoxicity determined on normal and colon cancer cells were communicated. The content of anthocyanins was significantly decreased during storage in coconut sugar-based jam, but was best preserved in jam with fructose and stevia. Fructose and stevia-based jams showed the highest inhibition activity upon α-glucosidase. Lingonberry jams showed no cytotoxic effects on normal cells, but at low concentration reduced the tumor cells viability. Anthocyanins were still detectable in rats’ blood streams after 24 h, showing a prolonged bioavailability in rats. This study brings important results that will enable the development of functional food products.
CARE TECHNOLOGY PROTOTYPE FOR FLUSHING PRACTICE IN INTRAVENOUS CATHETER MAINTENANCE

ABSTRACT Objective: to elaborate, based on the assessment of the nursing team’s flushing practice, a care technology prototype aimed at promoting good practices in intravenous catheter maintenance in intensive care. Method: a technology elaboration study, developed in three stages: flushing practice assessment through a questionnaire completed by 108 nursing professionals working in intravenous catheter maintenance in intensive care settings of a public hospital located in the city of Rio de Janeiro, Brazil. Data collection took place from November 2019 to January 2020, with descriptive and inferential data analysis; analysis of this practice regarding the existence of errors according to the main guidelines and scientific evidence, with classification of types of errors in the light of the conceptual framework of patient safety; and technology prototype development. Results: 88% of participants perform flushing in their practice; 49.5% apply the continuous pressure technique on the syringe plunger; 22% perform flushing before, between and after medication administration; predominance of use of volume and syringes with gauges of 5 ml and 10 ml. Variables related to knowledge were associated with not performing flushing. There were active and latent errors that guided the technology prototype construction. Conclusion: a care guide was built that aims to increase nursing team’s knowledge about good flushing practices and is configured as a barrier to error recurrence.
Understanding Citizens’ Tweets During and After the COVID-19 Pandemic in Saudi Arabia: A Thematic Analysis Study

The coronavirus began in December 2019; in Wuhan, China, later the virus spread rapidly within a relatively short period of time, causing a global pandemic. Therefore, the Saudi government responded to the threat of COVID-19 from the start by imposing a lockdown to curb the number of affected patients and to prevent the fast-spreading virus, such as turning to distance learning, banning travel, imposing curfews, and postponing social activities. As social activities and social communication were affected by the crisis, people in Saudi Arabia tend to increasingly use social media platforms, one of which is Twitter. Little is known about the Saudis’ reactions on Twitter during COVID-19 and after. Therefore, the present study aims to investigate how Saudi Twitter users express their feelings qualitatively during and after COVID-19 outbreaks. For the scope of this study, Arabic tweets related to COVID-19 expressed by Saudi citizens were collected from Twitter using the web scraping service Apify. The data covered the periods of COVID-19 from the 1st of January 2020 to the 7th of July 2022. The selection of these tweets was primarily based on trending hashtags and keywords populated from Saudi Arabia. A total of 11,900 Arabic tweets were obtained, and only 473 tweets were considered in this study. A qualitative thematic analysis of Saudis’ tweets resulted in the identification of five main themes: 1) negative attitudes (i.e., fear, frustration, and sadness, 309, 65%); 2) positive attitudes (56, 12%); 3) advise-giving (48, 10%); 4) humour (34, 7%); and 5) information-seeking (26, 5%). These findings suggest that Saudi governmental agencies should actively engage in two-way communication with the public, provide trustworthy information, and manage the crisis based on the public’s needs. Our present research has shown that Twitter is a valuable source of reality, reflecting unique experiences among its users. Thematic analysis has proven to be a useful approach in providing insightful information about the Saudis’ needs in times of crisis and after. In addition, governments and health authorities can have a better understanding of the public's needs and thus prepare their crisis management strategies in order to relieve the public’s psychological pressures.
Quasi-Projective Manifolds Uniformized by Carathéodory Hyperbolic Manifolds and Hyperbolicity of Their Subvarieties

Let $M$ be a Carathéodory hyperbolic complex manifold. We show that $M$ supports a real-analytic bounded strictly plurisubharmonic function. If $M$ is also complete Kähler, we show that $M$ admits the Bergman metric. When $M$ is strongly Carathéodory hyperbolic and is the universal covering of a quasi-projective manifold $X$, the Bergman metric can be estimated in terms of a Poincaré-type metric on $X$. It is also proved that any quasi-projective (resp. projective) subvariety of $X$ is of log-general type (resp. general type), a result consistent with a conjecture of Lang.
Biocontrol Screening of Endophytes: Applications and Limitations

The considerable loss of crop productivity each year due to plant disease or pathogen invasion during pre- or post-harvest storage conditions is one of the most severe challenges to achieving the goals of food security for the rising global population. Although chemical pesticides severally affect the food quality and health of consumers, a large population relies on them for plant disease management. But currently, endophytes have been considered one of the most suitable biocontrol agents due to better colonization and acclimatization potential. However, a very limited number of endophytes have been used commercially as biocontrol agents. Isolation of endophytes and their screening to represent potential characteristics as biocontrol agents are considered challenging by different procedures. Through a web search using the keywords “endophytes as biocontrol agents” or “biocontrol mechanism of endophytes,” we have succinctly summarised the isolation strategies and different in vitro and in vivo biocontrol screening methods of endophytic biocontrol agents in the present review. In this paper, biocontrol mechanisms of endophytes and their potential application in plant disease management have also been discussed. Furthermore, the registration and regulatory mechanism of the endophytic biocontrol agents are also covered.
Small Molecule RBI2 Disrupts Ribosome Biogenesis through Pre-rRNA Depletion

Simple Summary Ribosome biosynthesis has emerged as an excellent target for inhibition of cancer cell growth and proliferation. We used a high throughput screen to identify potent inhibitors of ribosome synthesis in malignant melanoma cells. Here, we show that the newly identified ribosome biogenesis inhibitor, RBI2, inhibits multiple cancer cell types by a mechanism of action that is distinct from previously described compounds. Using chromatin IP, isotopic labelling, and RNA sequencing, we conclude that treatment with RBI2 does not inhibit transcription initiation by RNA polymerase I, but appears to induce rapid polyadenylation and degradation of ribosomal RNA. This mechanism of action would be unique from previously described inhibitors of RNA polymerase I. Abstract Cancer cells are especially sensitive to perturbations in ribosome biogenesis as they rely on finely tuned protein homeostasis to facilitate their rapid growth and proliferation. While ribosome synthesis and cancer have a well-established relationship, ribosome biogenesis has only recently drawn interest as a cancer therapeutic target. In this study, we exploited the relationship between ribosome biogenesis and cancer cell proliferation by using a potent ribosome biogenesis inhibitor, RBI2 (Ribosome Biogenesis Inhibitor 2), to perturb cancer cell growth and viability. We demonstrate herein that RBI2 significantly decreases cell viability in malignant melanoma cells and breast cancer cell lines. Treatment with RBI2 dramatically and rapidly decreased ribosomal RNA (rRNA) synthesis, without affecting the occupancy of RNA polymerase I (Pol I) on the ribosomal DNA template. Next-generation RNA sequencing (RNA-seq) revealed that RBI2 and previously described ribosome biogenesis inhibitor CX-5461 induce distinct changes in the transcriptome. An investigation of the content of the pre-rRNAs through RT-qPCR revealed an increase in the polyadenylation of cellular rRNA after treatment with RBI2, constituting a known pathway by which rRNA degradation occurs. Northern blotting revealed that RBI2 does not appear to impair or alter rRNA processing. Collectively, these data suggest that RBI2 inhibits rRNA synthesis differently from other previously described ribosome biogenesis inhibitors, potentially acting through a novel pathway that upregulates the turnover of premature rRNAs.
Flavor Characterization of Native Xinjiang Flat Peaches Based on Constructing Aroma Fingerprinting and Stoichiometry Analysis

The flat peach is a high economic value table fruit possessing excellent quality and a unique aroma. This article investigated the quality characteristics and aroma fingerprinting of flat peaches (Qingpan, QP; Ruipan 2, R2; Ruipan 4, R4; Wanpan, WP) from Xinjiang in terms of taste, antioxidant capacity, and volatile aroma compounds using high-performance liquid chromatography (HPLC) and HS-SPME-GC-MS. The results showed that the flat peaches had a good taste and high antioxidant capacity, mainly due to the high sugar–low acid property and high levels of phenolic compounds. This study found that sucrose (63.86~73.86%) was the main sugar, and malic acid (5.93~14.96%) and quinic acid (5.25~15.01%) were the main organic acids. Furthermore, chlorogenic acid (main phenolic compound), epicatechin, rutin, catechin, proanthocyanidin B1, and neochlorogenic acid were positively related to the antioxidant activity of flat peaches. All flat peaches had similar aroma characteristics and were rich in aromatic content. Aldehydes (especially benzaldehyde and 2-hexenal) and esters were the main volatile compounds. The aroma fingerprinting of flat peaches consisted of hexanal, 2-hexenal, nonanal, decanal, benzaldehyde, 2,4-decadienal, dihydro-β-ionone, 6-pentylpyran-2-one, 2-hexenyl acetate, ethyl caprylate, γ-decalactone, and theaspirane, with a “peach-like”, “fruit”, and “coconut-like” aroma. Among them, 2,4-decadienal, 2-hexenyl acetate, and theaspirane were the characteristic aroma compounds of flat peaches. The results provide a theoretical basis for the industrial application of the special aroma of flat peaches.
THE EFFECT OF SOURCE OF STRESS AND COPING STRATEGY ON STRESS SYMPTOMS OF THE CUSTOMER’S FAMILY OF ILLEGAL LOANS

Human needs are so complex that it causes a mismatch between expenses and income generated. Debt is an alternative that is chosen so that family needs are still met, even though being in debt is prone to stress risks. This study aims to analyze the relationship between sources of stress, coping strategies, and stress symptoms, as well as the influence of sources of stress and coping strategies on the stress symptoms of illegal loans customers' families. The subjects in this study were active illegal loans customers in Purwasari Village. The sampling technique used simple random sampling method, which included quantitative research, with a sample size of 60 people. Data and information were collected through direct interviews using a questionnaire. Data were processed using descriptive, correlation, and multiple linear regression tests. The results showed that almost all sources of stress were in the low category, all coping strategies were in the low category, and more than half of the stress symptoms were in the low category. There is a significant positive relationship between the number of children and sources of stress, sources of stress are also significantly positively related to coping strategies and stress symptoms. There is a positive influence on the number of banks and sources of stress on the stress symptoms of illegal loans customers.
The aerodynamic optimization design of turbine cascade nonaxisymmetric endwall and the midgap influence assessment

The nonaxisymmetric endwall profiling has been proven to be an effective tool to reduce the secondary flow loss in turbomachinery. In the present work, first, without considering the endwall midgap in the real machine, an endwall optimization design procedure for reducing secondary flow losses has been developed, which allowed complete three-dimensional parameterization turbine endwall design. The profile of the endwall has been designed using automatic numerical optimization by means of an improved efficient global optimization algorithm based on kriging surrogate model. Next, a large-scale linear cascade with a low-speed wind tunnel has been chosen for the experimental validation of the optimization results. The experimental measurements and numerical simulations both demonstrated that the total pressure loss and secondary flow intensity were reduced with the nonaxisymmetric endwall used in the cascade passage. Then, in order to evaluate the ability of the optimized nonaxisymmetric endwall with the midgap, the midgap was added in for both the baseline flat endwall and the optimized nonaxisymmetric endwall in the numerical simulations analysis. The entropy generation rates analysis were used for the investigation of loss distribution in the passage. For the cascade in the present work, with the midgap added in, the optimized nonaxisymmetric endwall did not perform as well as the situation without the midgap in the loss reduction. In addition, comparing to the baseline flat endwall, the optimized nonaxisymmetric endwall needed more net leakage flow to avoid the ingress of passage flow into the midgap.
Self-Regulation Strategies in Online EFL/ESL Learning: A Systematic Review

Online learning environments contain many of the variables of face-to-face learning environments. However, the inability to be in the same physical environment may cause problems due to the student’s self-management of the process. At this point, self-regulation strategies (hereafter, SRS), also used in face-to-face learning, are essential in improving the process. This study (n=24) aims to present a broad perspective of the studies based on students’ SRS by focusing on online EFL/ESL learning research articles published in the last five (2018-2022) years. The studies determined by a search string and eligibility criteria were included in this systematic review using the PRISMA coding scheme guidelines and MAXQDA was employed for content analysis. 12 strategies were identified (self-evaluation, goal setting, time management, help-seeking, task strategy, environmental structuring, self-efficacy, strategic planning, self-observation/monitoring, self-satisfaction, achievement motivation, effort regulation/persistence) and 15 key attributes were found to support the student’s use of SRS in online language learning environments (motivation, interaction-feedback, metacognition, use of digital tools, pedagogical support, autonomous learning, good learning experience, positive belief, the reflection of the process, self-efficacy, authenticity, scaffolding, cultural interest, critical thinking, the flexibility of time). This study can serve as a guide when designing online environments for self-regulated language learning.
Electroencephalographic-based wearable instrumentation to monitor the executive functions during gait: a feasibility study

A feasibility study on electroencephalographic monitoring of executive functions during dual (motor and cognitive) task execution is presented. Electroencephalographic (EEG) signals are acquired by means of a wearable device with few channels and dry electrodes. The light weight and wireless device allow for walking in a natural way. The most significant EEG features are investigated to classify different levels of activation for two fundamental Executive Functions (EF) both in sitting and walking conditions. Power spectral density in the gamma band resulted in the most relevant feature in discriminating low and high levels of Inhibition. Power spectral density in the beta and gamma bands resulted the most discriminating the level of activation of Working Memory. The study poses the basis for (i) monitoring the activation levels of EF during Gait allowing loss prevention in the elderly and (ii) specific cognitive rehabilitation aimed at the most relevant executive functions during walking.
Effect of Geographical Location on the Phenolic and Mineral Composition of Chetoui Olive Leaves

In this study, we investigated the influence of pedological parameters and variation of altitude on the mineral nutrients, phenolic compounds, and antioxidant activities of olive leaves. Samples of the Chetoui cultivar were collected from eight geographical locations with different altitudes. Levels of phenolic compounds varied according to the altitude. Classification of the locations revealed that altitude 1 (>500 m) was characterized by high levels of secoiridoids and simple phenols, while altitude 2 (500–300 m) and altitude 3 (<300 m) were higher in flavonoids. Levels of Mn, Ca and B in the leaves and level of Zn in the soil were significantly correlated with the abundance of oleuropein and luteolin-7-O glucoside, the most important phenols in Chetoui olive leaves. The results suggest that, in addition to pedological criteria, environmental conditions also influence the formation of phenolic compounds.
Probing the standard model with rare charm decays

This thesis comprises a study of rare charm decays in the standard model (SM) and beyond. Within an effective theory framework, we calculate the SM Wilson coefficients to (partly) next-to-next-to leading logarithmic order in quantumchromodynamics. The calculation includes matching conditions and the running of the Wilson coefficients in the renormalization group-improved perturbation theory, thereby correcting expressions used in the literature. Furthermore, a calculation of phenomenological relevant two loop matrix elements of current-current operators is presented. We work out the phenomenology in the SM for radiative and semileptonic inclusive decays as well as the exclusive decays D → Pll and D → V γ, including non-perturbative effects. The branching ratios are dominated by resonances, yet we can construct various observables which cleanly probe the SM, e.g. asymmetries, angular observables and lepton flavor violating decays are (approximate) SM null tests. Beyond the SM physics effects are analyzed modelindependently and via leptoquark models, where various constraints and correlations, e.g. through flavor patterns, are worked out. In addition, we probe the SM by means of the decay Λc → pγ, which is accessible at (future) colliders, and investigate the radiative decays in supersymmetric models.