Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: Findings from a Mendelian randomisation study

Introduction Sepsis is characterised by dysregulated, life-threatening immune responses, which are thought to be driven by cytokines such as interleukin-6 (IL-6). Genetic variants in IL6R known to downregulate IL-6 signalling are associated with improved COVID-19 outcomes, a finding later confirmed in randomised trials of IL-6 receptor antagonists (IL6RA). We hypothesised that blockade of IL6R could also improve outcomes in sepsis. Methods We performed a Mendelian randomisation analysis using single nucleotide polymorphisms (SNPs) in and near IL6R to evaluate the likely causal effects of IL6R blockade on sepsis, sepsis severity, other infections, and COVID-19. We weighted SNPs by their effect on CRP and combined results across them in inverse variance weighted meta-analysis, proxying the effect of IL6RA. Our outcomes were measured in UK Biobank, FinnGen, the COVID-19 Host Genetics Initiative (HGI), and the GenOSept and GainS consortium. We performed several sensitivity analyses to test assumptions of our methods, including utilising variants around CRP in a similar analysis. Results In the UK Biobank cohort (N=485,825, including 11,643 with sepsis), IL6R blockade was associated with a decreased risk of sepsis (OR=0.80; 95% CI 0.66-0.96, per unit of natural log transformed CRP decrease). The size of this effect increased with severity, with larger effects on 28-day sepsis mortality (OR=0.74; 95% CI 0.38-0.70); critical care admission with sepsis (OR=0.48, 95% CI 0.30-0.78) and critical care death with sepsis (OR=0.37, 95% CI 0.14 - 0.98) Similar associations were seen with severe respiratory infection: OR for pneumonia in critical care 0.69 (95% CI 0.49 - 0.97) and for sepsis survival in critical care (OR=0.22; 95% CI 0.04- 1.31) in the GainS and GenOSept consortium. We also confirm the previously reported protective effect of IL6R blockade on severe COVID-19 (OR=0.69, 95% 0.57 - 0.84) in the COVID-19 HGI, which was of similar magnitude to that seen in sepsis. Sensitivity analyses did not alter our primary results. Conclusions IL6R blockade is causally associated with reduced incidence of sepsis, sepsis related critical care admission, and sepsis related mortality. These effects are comparable in size to the effect seen in severe COVID-19, where IL-6 receptor antagonists were shown to improve survival. This data suggests a randomised trial of IL-6 receptor antagonists in sepsis should be considered.
PATENT COOPERATIVE PATTERNS AND DEVELOPMENT TRENDS OF CHINESE CONSTRUCTION ENTERPRISES: A NETWORK ANALYSIS

Despite the rapid development of Chinese construction industry, there has been little research effort directed towards exploring patent cooperative patterns and evolution trends of construction enterprises, especially from the perspective of the patent development network. This paper extracts implicit collaborative information and introduces Social Network Analysis (SNA) method to conduct the patentometric analysis based on patent data from the “Top 500 Chinese Construction Enterprises” sourced from PatSnap database. The enterprise-enterprise networks and enterprise-university networks are analyzed quantitatively. The results reveal that: 1) there is a rising trend in the number of patents and patentees; 2) state-owned enterprises play a dominant role in patent development; 3) most of patents are classified as International Patent Classification E04G21; 4) the cooperative relationships are mainly within enterprises and their subsidiaries; 5) when enterprises choose to cooperate with universities, in addition to professional qualification, geographical factors should also be considered. Finally, the development and patent evolution trends are discussed. Some useful suggestions are proposed. The contribution lies in: (a) providing a visualization of the implicit collaboration information of patents in Chinese construction enterprises; (b) revealing cooperative patterns of construction enterprises on patents; and (c) providing enterprises some useful suggestions for patent cooperation.
EFFECT OF GLUTATHIONE ON THE FREEZABILITY AND IN VITRO FERTILIZING POTENTIALS OF BOVINE SPERMATOZOA

Cryopreservation induces sub lethal damage to the spermatozoa, thereby reduce their fertile life. In the present study, effect of glutathione on bovine semen freezability and in vitro fertilizing potentials were evaluated. Semen was cryopreserved in tris-based extender supplemented with different concentrations of reduced glutathione (0, 0.5, 1, 2, 3 and 5 mM). Semen post-thawing motility, viability and acrosomal integrity, DNA damage, enzymes leakage, total antioxidant capacity (TAC), lipid peroxidation and in vitro fertilizing potentials were assessed. Current results indicated that addition of 2 mM glutathione to semen extender significantly (P<0.05) improved
Effect of zinc supplementation on production performance and udder health of peri - parturient Karan Fries cows during heat stress

: Present study was carried out to evaluate the effect of zinc ( Zn ) supplementation on production performance and udder health of peri - parturient KF ( Karan Fries ) cows during heat stress condition . 18 peri - parturient Karan Fries cows were divided into three groups namely control, T1 and T2 having six cows in each group . Control group was fed basal diet alone, however T1 and T2 groups were fed with 80 ppm and 120 ppm Zn, respectively along with basal diet from 45 days pre - partum to 45 days post partum . Results showed that plasma Zn level was significantly higher in supplemented group than control ( P<0 . 05 ). Milk and fat - corrected milk yield in Karan Fries cows were significantly affected Zn supplementation ( p<0 . 05 ). Dry matter intakes ( DMI ) and composition of milk were not significantly different between control and treatments . However, Karan Fries cows that received supplemental Zn were having lower ( p<0 . 05 ) somatic cell count as compared to control . It was concluded that Zn supplementation in diet of peri - parturient Karan Fries cows result in significantly increased milk yield and lower somatic cell count . However, milk composition was not affected by supplemental Zn .
The Ethiopian Journal of Health Development Original Malnutrition among children in Southern Ethiopia: Levels and risk factors

Using data collected in the Community and Family Survey of the Southern Nations Nationalities and Peoples Region, this study estimates the level of child malnutrition and identifies the factors associated with chronic malnutrition among children in the five densely populated zones of the Region. A total of 850 children aged 3 - 36 months were included in the present study. Both bivariate and multivariate techniques were employed in order to identify risk factors of child malnutrition. The results indicate that about 45% of children are stunted, 42% underweight, and 12% wasted. The search for the factors affecting long-term nutritional status point to both socio-economic and demographic factors. Among the socio-economic factors, household economic status and women's education were important in explaining the variation in long-term nutritional status of children. From the demographic variables included in the analysis, age, preceding birth interval and number of under-five children were associated with stunting. Moreover, number of antenatal care visits the mother had during the pregnancy of the child and age at weaning are linked to chronic malnutrition. The study recommended the need for programs related to income-generating activities for poor households and family life education, including appropriate child care for women in reproductive age groups.
Ethnic diversity and informal intra- and inter-ethnic contacts with neighbours in The Netherlands: A comparison of natives and ethnic minorities

We have examined the extent to which ethnic diversity in neighbourhoods and municipalities in The Netherlands is related to personal contact with neighbours from ethnic in-groups and out-groups among the native majority as well as among ethnic minorities. The results indicate that ethnic diversity is negatively related to personal contacts with native neighbours, but positively to personal contacts with neighbours from other ethnic groups. This applies equally to native respondents and Turks and Moroccans, rejecting Putnam’s hunkering-down hypothesis and ethnic competition theory. Instead, ethnic diversity increases meeting opportunities with ethnic minorities while decreasing meeting opportunities with the native majority.
Identification by comparison of caries free bitewing radiographs: Impact of observer qualifications and their clinical experience

Dental identification is one of the primary methods of identifying unknown human remains. It is based upon the comparison of post mortem findings with ante mortem dental records. Comparison of dental radiographs is recognized as integral to this process. In many parts of the world caries rates have fallen and many young people have no restorations. This makes dental identification more challenging and necessitates the comparison of anatomical structures. The aim of this study was to compare the ability of a variety of dentists and forensic toxicologists to correctly match restoration and caries free bitewing radiographs of children taken a number of years apart. 7 sets of radiographs which were taken 4 years apart were given to 22 examiners and were asked to sort them into seven matching pairs. The number of correctly matched pairs, the features used for comparison and the time taken for the matching was recorded. A comparison between the different groups was made. Of the potential 154 matched pairs of radiographs, a total of 115 pairs were identified correctly. The senior clinicians, recently qualified dentists, post graduate dental students and forensic specialists correctly identified 71.5%, 77%, 78.5% and 71.5% matches respectively. This simulated radiographic identification test may identify that clinical experience is not related to making correct matches. Formal training in dental identification might be helpful, so that dentists of varied experience levels (seniors &juniors) and forensic specialists can take part in an identification team when needed.
Enterprise Risk Management And Corporate Governance In Indonesia Banking Industry

- The purpose of this research was to determine the effect of firm size, auditor reputation, ownership concentration, and leverage variables on the application of enterprise risk management in the banking industry. The study was conducted on some banks listed on the Indonesia stock exchange and with a complete financial report during the period of the research. The descriptive statistical, classical assumption, and multiple regression methods of analysis were employed with enterprise and risk management proxied by COSO. The results showed a significant favorable influence of firm size and a negative effect of leverage variables on the application of company risk management. The managerial implications of this are that the use of a risk management company requires the consideration of the size of the company and ensuring the leverage is within reasonable limits. Moreover, for investors, attention should be paid to the historical development of these two variables. This research contributes to the empirical study of risk management and corporate governance theory by exploring the factors associated with the extent of firms’ ERM application, providing insight into practices adopted by Indonesia Listed companies, and ensuring there is more focus on the management of internal banking variables.
Distant activity of Comet C/2001 K5 (LINEAR)

CCD observations of Comet C/2001 K5 (LINEAR) were made at the 60-cm telescope of the Andrushivka Astronomical Observatory on October 27, 2003. Developed codes for simulation of dust environment in distant comets were applied to fit dust tail of the comet. Model runs are successful under assumption that the dust tail is formed by “dirty” ice grains. The trajectories of the cometary particles were calculated taking into account variation of their mass due to sublimation in the solar radiation field. Outflow velocities of the grains out of the collisional zone are very slow and equal, in particular, to 10.7 m s−1 for particles having a size of 5 μm at a heliocentric distance of 5.9 AU. The dust size distribution of the ejected particles is significantly different from those in the observed tail. The dust size distributions in different parts of the appeared tail vary widely as well.
To Investigate Behavioral Changes Across Different Cultures At University Level

This study examines the behavioral changes across different cultures at university level. Descriptive design was used by survey method. BS and MS Female students of Education department of International Islamic University were considered as population of this study. 785 samples were calculated through Epi Tool- a free web-based calculator. Self-developed questionnaire was used in this study. It consisted of 35 items. Descriptive (Mean & Percentage) and inferential statistics (t-test and ANOVA test) were used to analyzed data. It was found that Female students were neutral about their behavioral variations across different culture like stereotypical, migration, social attitude and behavior, coping strategy and performance and adaptation at university level. Nationality and level of Education had no significant effect over the students’ opinions about behavioral variations across different culture at university level.
PREVALENCE OF YEAST IN SOME CHICKEN MEAT PRODUCTS

This study was carried out upon 60 samples of chicken luncheon, pane and nuggets (20 of each), samples were collected from different markets at Dakhlia governorate and conducted to evaluate the total yeast count and the mycological profiles. The mean values of the total yeast counts of chicken luncheon, pane and nuggets (cfu/g) were 7.1×10 3 ±3.1 ×10 3 , 1.8×10 5 ± 8.2×10 4 , 2.4×10 6 ±1.4×10 6 , respectively. There was a significant difference in total yeast count between chicken luncheon and nuggets. Chicken nuggets were the most contaminated samples with yeast, while chicken luncheon was the lowest contaminated samples. One hundred and five (105) yeast isolates represented 4 genera were isolated from chicken luncheon, pane and nuggets samples in the following number and percentage, Candida, 14 (58.3%), 22(59.5%), 25(56.8%) with the highest total incidence of 61(58%) followed by Rhodotorula 7(29.1%), 11(29.7), 13(29.5%) with total incidence of 31(29.5%) followed by Saccharomyces, 3 (12.5%),3 (8.1%),4 (9.1%) with total incidence 10(9.5%), and finally, Trichosporon 0(0%),1(2.7%), 2(4.5%) with total incidence 3(2.9%), respectively. Regarding yeast species isolated from chicken luncheon, pane and nuggets, C. albicans were the most predominant species which isolated from 40%, 75% and 85% of examined samples represented by the following number and percentage 8(33.3%), 15(40.5%) and 17(38.6%), respectively. The yeast isolates were identified using traditional standard method. Six samples examined using PCR, all of them were successfully amplified a products of 109 bp and interpreted as positive for Candida albicans which confirmed the results obtained by traditional method. While 2 samples amplified a products of 919 bp and proved to be positive for killer gene (KHS) of S. cerviciae and one samples amplified a product of 727 bp and give positive killer genes (PelA).
An Investigation of Solar Features, Test Environment, and Gender Related to Consciousness-Correlated Deviations in a Random Physical System

—Whereas a multitude of solar and geomagnetic variables were not correlated with signifi cant deviations in continuous measurements from random physical systems (Random Event Generators), these variables were moderately correlated with REG output during periods of intention. The scalar components (2–10 nT) of the Interplanetary Magnetic Field ( r = ~0.50) and global geomagnetic activity ( r = ~0.55) were signifi cantly correlated with REG deviations during the second minute of intention. Signifi cance compared with nonsuccessful deviations occurred during periods of intention when the Solar Radio Flux was about 20 units (2∙10 −21 W∙m −2 Hz −1 ) higher. The polarity of the deviation was diff erent within a Faraday (echoic) chamber than in a normal environment as well as between genders. The amount of energy associated with the increase in geomagnetic activity within the volume of human cerebrum is remarkably similar to the gravitational energy within this mass because of minute variations in G (the Gravitational Constant). These results indicate that a subset of variance shared across several components of the ambient heliogeophysical environment may be a signifi cant mediator of intention-coupled changes in random variations in p-n junction devices, and those discrete energies associated with intrinsic variations in G may be relevant.
COST OF NULL CONTROLLABILITY FOR PARABOLIC EQUATIONS WITH VANISHING DIFFUSIVITY AND A TRANSPORT TERM

In this paper we consider the heat equation with Neumann, Robin and mixed boundary conditions (with coeﬃcients on the boundary which depend on the space variable). The main results concern the behaviour of the cost of the null controllability with respect to the diﬀusivity when the control acts in the interior. First, we prove that if we almost have Dirichlet boundary conditions in the part of the boundary in which the ﬂux of the transport enters, the cost of the controllability decays for a time T suﬃciently large. Next, we show some examples of Neumann and mixed boundary conditions in which for any time T > 0 the cost explodes exponentially as the diﬀusivity vanishes. Finally, we study the cost of the problem with Neumann boundary conditions when the control is localized in the whole domain.
Non-Tariff Barriers, Integration, and the Trans-Atlantic Economy

: We examine the potential impact of T-TIP through trade cost reductions, applying a mix of econometric and computational methods to develop estimates of the benefits (and costs) for the EU, US, and third countries. Econometric results point to an approximate 80 percent growth in bilateral trade with an ambitious trade agreement. However, at the same time, CGE estimates highlight distributional impacts across countries and factors not evident from econometrics alone. Translated through our CGE framework, while bilateral trade increases roughly 80 percent, there is a fall of about 2.5 percent in trade with the rest of the world in our central case. The estimated gains in annual consumption range between 1 and 2.25 percent for the US and EU respectively. A purely discriminatory agreement would harm most countries outside the agreement, while the direction of third-county effects hinges critically on whether NTB reductions end up being discriminatory or not. Within the US and EU, while labor gains across skill categories, the impact on farmers is mixed.
Effect of Two Standardized Oral Hygiene Methods on Bacterial Colonization in Mechanically Ventilated Patients

Oral hygiene is an essential aspect of daily nursing care activity, Oral hygiene in critical often neglected or performed inadequately. Literature cited many oral hygiene solution as Chlorhexidine, Sodium Bicarbonatele, hydrogen peroxide and normal saline. Oral hygiene solutions leads to decrease colonization of the oropharynx, remove debris, and lowers VAP level. Literatures did not mention the most effective method including the solutions and the appropriate frequency of oral hygiene for critical ill patients. The aim of study : is to evaluate the effect of two standardized oral Hygiene methods on bacterial colonization in mechanically ventilated patients. Patients and method: A quasi experimental research was conducted at ICU of Minia university hospital. Sixty adult critical patients assigned randomly in two groups, 30 for each. Chlorhexidine (0.2%) group (A) and Sodium Bicarbonate (0.1%) group (B). Three tools used : Bacterial Colonization Indicators, Beck Oral Assessment Scale & Mucosal-Plaque scale . Results: on 7th day of the study a higher percentage (87 %) of Chlorhexidine group (A) had good oral integrity, and only (26.7 %) of the same group had VAP than group (B) (73.3 %). Conclusions: Oral hygiene using tooth brushing with Chlorhexidine leads to improve oral cavity reducing colonization as well as VAP prevention.
The Effects of Perceived Trust and Ease of Use on Adoption of Mobile Marketing in the Telecommunication Industry of Tanzania

This study examines the effects of perceived trust and perceived ease of use on the adoption of mobile marketing in the telecommunications industry of Tanzania. Guided by the Technology Acceptance Model (TAM) it predicts the adoption of mobile marketing in the Telecommunications industry in Tanzania. Survey strategy was employed in data collection, using structured questionnaires and collected data from 5 municipalities, 73 wards and 6 hamlets, by using multi stage sampling of 406 respondents in Dar es Salaam. Quantitative data were analyzed using multiple linear regression. Findings indicate that perceived ease of use and perceived trust had positive and significant influence on the adoption of mobile marketing. We provide recommendations to the telecommunications companies to improve their mobile marketing products and services by making better products that are easy to use and trustworthy so as to conform to the needs of their customers.