Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-Objective Optimization Applied to the Design of Sustainable Pedestrian Bridges

The demand for more sustainable structures has been shown as a growing tendency, and engineers can use optimization techniques to aid in the design and sizing stage, achieving solutions that minimize its cost and environmental and social impacts. In pedestrian bridges, which are subjected to human-induced vibrations, it is also important to ensure the users’ comfort, besides the security verifications. In this context, the objective of this paper is to perform a multi-objective optimization of a steel-concrete composite pedestrian bridge, minimizing cost, carbon dioxide emissions, and vertical acceleration caused by human walking. For this, the Multi-Objective Harmony Search (MOHS) was applied to obtain non-dominated solutions and compose a Pareto Front. Two scenarios were considered with different unit emissions obtained from a life cycle assessment in the literature. Results show that by increasing 15% the structure cost, the vertical acceleration is reduced from 2.5 to 1.0 m/s2. For both scenarios, the optimal ratio for the web height and total span (Le) lies between Le/20 and Le/16. The web height, the concrete strength, and the slab thickness were the design variables with more influence on the value of the vertical acceleration. The Pareto-optimal solutions were considerably sensitive to the parameters varied in each scenario, changing concrete consumption and dimensions of the welded steel I-beam, evidencing the importance of carrying out a sensitivity analysis in optimization problems.
Assessing the Errors in Shortwave Radiative Fluxes Inferred from the Geostationary Earth Radiation Budget (GERB) Instrument in the Presence of Dust Aerosol

Abstract The Geostationary Earth Radiation Budget (GERB) instruments flying on the Meteosat Second Generation series of satellites provide a unique tool with which to monitor the diurnal evolution of top-of-atmosphere broadband radiation fields. GERB products, which have recently been released to the scientific community, include aerosol information in addition to the observed radiances and inferred fluxes. However, no account of the anisotropic characteristics of aerosol has been incorporated in the radiance-to-flux conversion, which uses angular distribution models developed for clear or cloudy conditions. Here an attempt is made to quantify the impact of this omission in the shortwave (SW), focusing on dust-contaminated scenes. An observationally based representation of dust is used to develop a theoretical angular distribution model, which is tested through comparison with observed GERB radiances. For dusty scenes that have been processed as clear ocean, applying the dust model to convert GERB radianc.
Singular perturbation analysis of an acoustically levitated sphere: Flow about the velocity node

This analysis consists of the development of the fluid flow about a spherical particle placed at the velocity node of a standing wave. High-frequency acoustic fields are being used to levitate particles in Earth gravity, and to stabilize particles in low-gravity situations. While a standing wave in an infinite medium may be purely oscillatory with no net flow components, the interaction with particles or solid walls leads to nonlinear effects that create a net steady component of the flow. In the present development, the perturbation method is employed to derive the flow field for the situation when a spherical particle is positioned at the velocity node. As found in an earlier analysis [Riley, Q. J. Mech. Appl. Math 19, 461 (1966)] applicable to a solid sphere at the velocity antinode, there is a thin shear-wave region adjacent to the spherical boundary. However, this thin Stokes layer does not cover the entire sphere in the same manner as in the previous case. In the polar regions flow reversal takes pl.
Renin–angiotensin–aldosterone pathway modulators in chronic kidney disease: A comparative review

Chronic kidney disease presents a health challenge that has a complex underlying pathophysiology, both acquired and inherited. The pharmacotherapeutic treatment options available today lower the progression of the disease and improve the quality of life but cannot completely cure it. This poses a challenge to the healthcare provider to choose, from the available options, the best way to manage the disease as per the presentation of the patient. As of now, the recommended first line of treatment to control the blood pressure in chronic kidney disease is the administration of renin–angiotensin–aldosterone system modulators. These are represented mainly by the direct renin inhibitor, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers. These modulators are varied in their structure and mechanisms of action, hence showing varying treatment outcomes. The choice of administration of these modulators is determined by the presentation and the co-morbidities of the patient, the availability and affordability of the treatment option, and the expertise of the healthcare provider. A direct head-to-head comparison between these significant renin–angiotensin–aldosterone system modulators is lacking, which can benefit healthcare providers and researchers. In this review, a comparison has been drawn between the direct renin inhibitor (aliskiren), angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers. This can be of significance for healthcare providers and researchers to find the particular loci of interest, either in structure or mechanism, and to intervene as per the case presentation to obtain the best possible treatment option.
Genotype–Phenotype Correlations in 2q37-Deletion Syndrome: An Update of the Clinical Spectrum and Literature Review

2q37 microdeletion/deletion syndrome (2q37DS) is one of the most common subtelomeric deletion disorders, caused by a 2q37 deletion of variable size. The syndrome is characterized by a broad and diverse spectrum of clinical findings: characteristic facial dysmorphism, developmental delay/intellectual disability (ID), brachydactyly type E, short stature, obesity, hypotonia in infancy, and abnormal behavior with autism spectrum disorder. Although numerous cases have been described so far, the exact mapping of the genotype and phenotype have not yet been achieved. Materials and Methods: In this study we analyzed nine newly diagnosed cases with 2q37 deletion (3 male/6 female, aged between 2 and 30 years old), and followed up at the Iasi Regional Medical Genetics Centre. All patients were tested first with MLPA using combined kits P036/P070 subtelomeric screening mix and follow-up mix P264; after, the deletion size and location were confirmed via CGH-array. We compared our findings with the data of other cases reported in the literature. Results: From nine cases, four had pure 2q37 deletions of variable sizes, and five presented deletion/duplication rearrangements (with chromosomes 2q, 9q, and 11p). In most cases, characteristic phenotypic aspects were observed: 9/9 facial dysmorphism, 8/9 global developmental delay and ID, 6/9 hypotonia, 5/9 behavior disorders, and 8/9 skeletal anomalies—especially brachydactyly type E. Two cases had obesity, one case had craniosynostosis, and four had heart defects. Other features found in our cases included translucent skin and telangiectasias (6/9), and a hump of fat on the upper thorax (5/9). Conclusions: Our study enriches the literature data by describing new clinical features associated with 2q37 deletion, and possible genotype–phenotype correlations.
Germanium-tin n-channel tunneling field-effect transistor: Device physics and simulation study

We investigate germanium-tin alloy (Ge1−xSnx) as a material for the design of tunneling field-effect transistor (TFET) operating at low supply voltages. Compared with Ge, Ge1−xSnx has a smaller band-gap. The reported band-gap of Ge0.89Sn0.11 is 0.477 eV, ∼28% smaller than that of Ge. More importantly, Ge1−xSnx becomes a direct band-gap material when Sn composition x is higher than 0.11. By employing Ge1−xSnx in TFET, direct band-to-band tunneling (BTBT) is realized. Direct BTBT generally has higher tunneling probability than indirect BTBT. The drive current of TFET is boosted due to the direct BTBT and the reduced band-gap of Ge1−xSnx. Device simulations show that the drive current and subthreshold swing S characteristics of Ge1−xSnx TFETs with x ranging from 0 to 0.2 are improved by increasing the Sn composition x. For Ge0.8Sn0.2 TFET, sub-60 mV/decade S is achieved at a high current level of ∼8 μA/μm. For x higher than 0.11, Ge1−xSnx TFETs show higher on-state current ION compared to Ge TFET at a supply.
Lipid metabolism-related gene signature predicts prognosis and depicts tumor microenvironment immune landscape in gliomas

Background Glioma is the most common primary brain tumor in adults and accounts for more than 70% of brain malignancies. Lipids are crucial components of biological membranes and other structures in cells. Accumulating evidence has supported the role of lipid metabolism in reshaping the tumor immune microenvironment (TME). However, the relationship between the immune TME of glioma and lipid metabolism remain poorly described. Materials and methods The RNA-seq data and clinicopathological information of primary glioma patients were downloaded from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA). An independent RNA-seq dataset from the West China Hospital (WCH) also included in the study. Univariate Cox regression and LASSO Cox regression model was first to determine the prognostic gene signature from lipid metabolism-related genes (LMRGs). Then a risk score named LMRGs-related risk score (LRS) was established and patients were stratified into high and low risk groups according to LRS. The prognostic value of the LRS was further demonstrated by construction of a glioma risk nomogram. ESTIMATE and CIBERSORTx were used to depicted the TME immune landscape. Tumor Immune Dysfunction and Exclusion (TIDE) was utilized to predict the therapeutic response of immune checkpoint blockades (ICB) among glioma patients. Results A total of 144 LMRGs were differentially expressed between gliomas and brain tissue. Finally, 11 prognostic LMRGs were included in the construction of LRS. The LRS was demonstrated to be an independent prognostic predictor for glioma patients, and a nomogram consisting of the LRS, IDH mutational status, WHO grade, and radiotherapy showed a C-index of 0.852. LRS values were significantly associated with stromal score, immune score, and ESTIMATE score. CIBERSORTx indicated remarkable differences in the abundance of TME immune cells between patients with high and low LRS risk levels. Based on the results of TIDE algorithm, we speculated that the high-risk group had a greater chance of benefiting from immunotherapy. Conclusion The risk model based upon LMRGs could effectively predict prognosis in patients with glioma. Risk score also divided glioma patients into different groups with distinct TME immune characteristics. Immunotherapy is potentially beneficial to glioma patients with certain lipid metabolism profiles.
Impact of Pharmacist-Led Multidisciplinary Team to Attain Targeted Vancomycin Area under the Curved Monitoring in a Tertiary Care Center in Thailand

Vancomycin Area Under the Curve (AUC) monitoring has been recommended to ensure successful clinical outcomes and minimize the risk of nephrotoxicity, rather than traditional trough concentration. However, vancomycin AUC monitoring by a pharmacist-led multidisciplinary team (PMT) has not been well established in Southeast Asia. This study was conducted at Thammasat University Hospital. Adult patients aged ≥ 18 years who were admitted and received intravenous vancomycin ≥48 h were included. The pre-PMT period (April 2020–September 2020) was defined as a period using traditional trough concentration, while the post-PMT period (October 2020–March 2021) was defined as a period using PMT to monitor vancomycin AUC. The primary outcome was the rate of achievement of the therapeutic target of an AUC/MIC ratio of 400–600. There was a significantly higher rate of achievement of therapeutic target vancomycin AUC during post-PMT period (66.7% vs. 34.3%, p < 0.001). Furthermore, there was a significant improvement in the clinical cure rate (92.4% vs. 69.5%, p < 0.001) and reduction in 30-day ID mortality (2.9% vs. 12.4%, p = 0.017) during the post-PMT period. Our study demonstrates that PMT was effective to help attain a targeted vancomycin AUC, improve the clinical cure rate, and reduce 30-day ID mortality. This intervention should be encouraged to be implemented in Southeast Asia.
An Objective Analysis of Tornado Risk in the United States

AbstractIn this paper, an objective analysis of spatial tornado risk in the United States is performed, using a somewhat different dataset than in some previous tornado climatologies. The focus is on significant tornadoes because their reporting frequency has remained fairly stable for several decades. Also, data before 1973 are excluded, since those tornadoes were rated after the fact and were often overrated. Tornado pathlength within the vicinity of a grid point is used to show tornado risk, as opposed to tornado days or the total number of reported tornadoes. The possibility that many tornadoes in the Great Plains were underrated due to the lack of damage indicators, causing a low bias in the number of significant tornadoes there, is mostly discounted through several analyses. The kernel density analysis of 1973–2011 significant tornadoes performed herein shows that the area of highest risk for tornadoes in the United States extends roughly from Oklahoma to Tennessee and northwestern Georgia, with the.
Junctures in the time of COVID-19: Topic search and government's framing of COVID-19 response in the Philippines

This article argues that, like many in Southeast Asia, the Philippine government's COVID-19 response was marked by policy experimentation and incremental adaptation, having been caught off-guard by the pandemic. Examining 16,281 government press releases related to COVID-19 issued by the Philippine News Agency between February 2020 and April 2021, we find that in its policy narratives the government panders initially to citizen demand, highlighting social amelioration as a pandemic strategy. However, as citizens’ economic anxiety further intensifies, the government's framing of the crisis response becomes pragmatic and turns towards promoting mass inoculation, ostensibly in a bid to convince citizens to choose health over short-term palliative economic measures. The findings nuance policymaking in an illiberal democracy, beyond the conventional populist description of seeking easy solutions or spectacularizing crisis response.
Limited N-Glycan Processing Impacts Chaperone Expression Patterns, Cell Growth and Cell Invasiveness in Neuroblastoma

Simple Summary The attachment of sugar residues to proteins is known as glycosylation. Glycosylation is a stepwise process which is significantly altered during cancer and may thus serve as both a therapeutic and/or diagnostic target. However, our understanding of how and which glycan structures contribute to aggressive cancer behaviors is lacking. In this study, we examined how specific N-glycans contribute to aggressive neuroblastoma behavior. Here, we use genetic editing to direct N-glycan expression in neuroblastoma cells, thus enabling us to assign specific N-glycan structures to cellular properties of neuroblastoma. In addition, we also examine how altering the process of N-glycosylation influences the expression of endoplasmic reticulum (ER) folding and transport proteins. It is critical to understand how N-glycosylation processing may influence ER folding and transport protein expression. This study demonstrates that alterations of N-glycosylation influence neuroblastoma progression by diminishing or enhancing cellular properties associated with cancer progression, along with influencing the expression pattern of ER folding and transport proteins. Abstract Enhanced N-glycan branching is associated with cancer, but recent investigations supported the involvement of less processed N-glycans. Herein, we investigated how changes in N-glycosylation influence cellular properties in neuroblastoma (NB) using rat N-glycan mutant cell lines, NB_1(-Mgat1), NB_1(-Mgat2) and NB_1(-Mgat3), as well as the parental cell line NB_1. The two earlier mutant cells have compromised N-acetylglucosaminyltransferase-I (GnT-I) and GnT-II activities. Lectin blotting showed that NB_1(-Mgat3) cells had decreased activity of GnT-III compared to NB_1. ESI-MS profiles identified N-glycan structures in NB cells, supporting genetic edits. NB_1(-Mgat1) had the most oligomannose N-glycans and the greatest cell invasiveness, while NB_1(-Mgat2) had the fewest and least cell invasiveness. The proliferation rate of NB_1 was slightly slower than NB_1(-Mgat3), but faster than NB_1(-Mgat1) and NB_1(-Mgat2). Faster proliferation rates were due to the faster progression of those cells through the G1 phase of the cell cycle. Further higher levels of oligomannose with 6–9 Man residues indicated faster proliferating cells. Human NB cells with higher oligomannose N-glycans were more invasive and had slower proliferation rates. Both rat and human NB cells revealed modified levels of ER chaperones. Thus, our results support a role of oligomannose N-glycans in NB progression; furthermore, perturbations in the N-glycosylation pathway can impact chaperone systems.
Social entrepreneurial intention among working adults: An emerging country context

Under the premise of the value-belief-norm (VBN) model, this study examined the influence of values, beliefs and norms on social entrepreneurial intention of working adults in China. The cross-sectional design was employed, and an online survey, which involved 1,075 working adults, was conducted. All data were analyzed using partial least squares-structural equation modeling (PLS-SEM). The obtained results showed the significant and positive influence of self-enhancement, openness to change, and self-transcendence on the sense of meaning and purpose. Moreover, the sense of meaning and purpose exhibited significant and positive influence on problem awareness, and problem awareness was found to have positive effect on outcome efficacy. Besides that, the sense of meaning and purpose, problem awareness, outcome efficacy, and injunctive social norms were found to exhibit significant and positive on personal norms. Finally, personal norms and injunctive social norms exhibited statistically significant and positive influence on social entrepreneurial intention. The results of effect size confirmed the considerable influence of personal norms and injunctive social norms on social entrepreneurial intention. Therefore, policy development aimed at promoting socioeconomic and environmental sustainability through social entrepreneurship should comprehensively consider the influence of personal norms and injunctive social norms. Increasing the sense of meaning and purpose of the working population, prompting an increased problem consequence and outcome self-efficacy, as well as instilling personal norms and injunctive social norms through various social and environmental incentives are recommended.
Characterization of the Dynamic Gastrointestinal Digests of the Preserved Eggs and Their Effect and Mechanism on HepG2 Cells

Preserved eggs, an alkaline-fermented food, have been widely searched for their anti-inflammatory activity. Their digestive characteristics in the human gastrointestinal tract and anti-cancer mechanism have not been well explained. In this study, we investigated the digestive characteristics and anti-tumor mechanisms of preserved eggs using an in vitro dynamic human gastrointestinal-IV (DHGI-IV) model. During digestion, the sample pH dynamically changed from 7.01 to 8.39. The samples were largely emptied in the stomach with a lag time of 45 min after 2 h. Protein and fat were significantly hydrolyzed with 90% and 87% digestibility, respectively. Moreover, preserved eggs digests (PED) significantly increased the free radical scavenging activity of ABTS, DPPH, FRAP and hydroxyl groups by 15, 14, 10 and 8 times more than the control group, respectively. PED significantly inhibited the growth, cloning and migration of HepG2 cells at concentrations of 250–1000 μg/mL. Meanwhile, it induced apoptosis by up/down-regulating the expression of the pro-apoptotic factor Bak and the anti-apoptotic gene Bcl-2 in the mitochondrial pathway. PED (1000 μg/mL) treatment resulted in 55% higher ROS production than the control, which also led to apoptosis. Furthermore, PED down-regulated the expression of the pro-angiogenic genes HIF-1α and VEGF. These findings provided a reliable scientific reference for the study of the anti-tumor activity of preserved eggs.
Natural Plant Extract – Loganin: A Hypothesis for Psoriasis Treatment Through Inhibiting Oxidative Stress and Equilibrating Immunity via Regulation of Macrophage Polarization

Abstract Psoriasis, a chronic immune-mediated inflammatory skin disease, influences approximately 2–3% of the world’s population. At present, the etiology of psoriasis remains unclear and there is still no causal treatment available. Recent studies indicate that oxidative stress (OS) and T cells dysregulation may participate in the pathogenesis of psoriasis, among which M1-dominant macrophage polarization is a crucial contributor. Macrophages mainly polarize into two different subsets, ie, classically activated macrophage (M1) and alternatively activated macrophage (M2). M1 polarization tends to exacerbate psoriasis via producing substantial reactive oxygen species (ROS) and inflammatory mediators, to encourage OS invasion and T cells dysregulation. Thus, targeting M1 polarization can be a possible therapeutic alternative for psoriasis. Loganin, belonging to iridoid glycosides, is a pharmaceutically active ingredient originated from Cornus officinalis, exerting multiple biological activities, eg, immunomodulation, antioxidation, anti-inflammation, etc. More importantly, it could effectively suppress M1 polarization, thereby arresting OS aggression and T cells’ dysregulation. Numerous studies have confirmed that loganin is quite reliable for diseases treatment via suppressing M1 polarization. Nevertheless, reports about loganin treating psoriasis have seldom appeared so far. Accordingly, we hold a hypothesis that loganin would availably manage psoriasis through preventing M1 polarization. Data from previous studies guarantee the potential of loganin in control of psoriasis.
Conservation and Linear Rossby-Mode Dispersion on the Spherical C Grid

Abstract Discretizations of the linearized shallow-water equations on a spherical C grid are considered. Constraints on the schemes' coefficients that ensure conservation of mass, angular momentum, and energy are derived. These results generalize previously published results to the case of nonuniform and rotated grids (but are restricted to the linearized equations). Grids with υ stored at the poles and grids with u and h stored at the poles are both considered. Energy conservation is shown to be problematic for grids with u and h at the poles. It is also shown that an inappropriate averaging of the Coriolis terms leads to a misrepresentation of the Rossby modes with shortest meridional scale. The appropriate averaging is shown to be compatible with the constraints required for conservation, and, indeed, the energy-conserving averaging of the Coriolis terms improves the dispersion properties of Rossby modes.