Miracle-dz/UniFAR-FTUs huggingface dataset:
Deprescribing as an Opportunity to Facilitate Patient-Centered Care: A Qualitative Study of General Practitioners and Pharmacists in Japan

Deprescribing has recently been applied to address polypharmacy, particularly among older adults. However, the characteristics of deprescribing that are likely to improve health outcomes have not been well studied. This study explored the experiences and perspectives of general practitioners and pharmacists with regard to deprescribing in older adults with multimorbidity. A qualitative study was conducted involving eight semi-structured focus group interviews with 35 physicians and pharmacists from hospitals, clinics, and community pharmacies. Thematic analysis was applied to identify themes using the theory of planned behavior as a guide. The results illustrated a metacognitive process, as well as influencing factors, through which healthcare providers commit to shared decision making for deprescribing. Healthcare providers acted on the basis of their attitudes and beliefs on deprescribing, the influence of subjective norms, and perceived behavioral control for deprescribing. These processes are influenced by factors such as drug class, prescribers, patients, deprescribing experience, and environment/education. Healthcare providers’ attitudes, beliefs, and behavioral control (along with deprescribing strategies) evolve in a dynamic interplay with experience, environment, and education. Our results can serve as a foundation for the development of effective patient-centered deprescribing to improve the safety of pharmaceutical care for older adults.
The structure of katabatic flows down a simple slope

An analysis of the katabatic flow structure is presented, based on data collected along a simple slope over a two‐month period. Four meteorological stations were deployed along the nearly two‐dimensional east slope of Mt. Hymettos in Greece. The study focuses on the momentum and energy budgets of the flows during carefully selected stationary periods with negligible ambient winds. In order to achieve a proper selection, the mean features of the observed flows are presented along with their response to external winds. The observed profiles are successfully compared with the theoretical Prandtl profiles. Bulk quantities of the katabatic layer are compared with proposed experimental values in order to check the representativity of the observed flows. These comparisons offer a further test of theoretical considerations and assist in discussions of processes affecting mean‐flow features.
Splitting off free summands of torsion-free modules over complete DVRs

If R is a complete discrete valuation ring and M is a reduced, torsion-free R-module of rank \kappa, where \aleph_0 \leq \kappa < 2^ (\aleph_0), we show that M \prop\oplus_(\aleph_0) R \oplus C for some R-module C. As a consequence, it must be the case that M \prop M \oplus (\oplus{_\alpha}R), where \alpha \leq \aleph_0, and {\rm (End)_R}M/\rm (Fin)M has rank at least 2^ (\aleph_0), where Fin M denotes the set of endomorphisms of M with finite rank image.
Opium consumption and long-term outcomes of CABG surgery in patients without modifiable risk factors

Background The question about the significance of opium consumption as a coronary artery disease (CAD) risk factor still remains open. The present study aimed to evaluate the association between opium consumption and long term outcomes of coronary artery bypass grafting (CABG) in patients without standard modifiable CAD risk factors (SMuRFs; hypertension, diabetes, dyslipidemia, and smoking). Methods In this registry-based design, we included 23,688 patients with CAD who underwent isolated CABG between January 2006 to December 2016. Outcomes were compared in two groups; with and without SMuRF. The main outcomes were all-cause mortality, fatal and nonfatal cerebrovascular events (MACCE). Inverse probability weighting (IPW) adjusted Cox's proportional hazards (PH) model was used to evaluate the effect of opium on post-op outcomes. Results During 133,593 person-years of follow-up, opium consumption was associated with increased risk of mortality in both patients with and without SMuRFs (weighted Hazard Ratio (HR)s: 1.248 [1.009, 1.574] and 1.410 [1.008, 2.038], respectively). There was no association between opium consumption and fatal and non-fatal MACCE in patients without SMuRF (HR = 1.027 [0.762–1.383], HR 0.700 [0.438–1.118]). Opium consumption was associated with earlier age of CABG in both groups; 2.77 (1.68, 3.85) years in SMuRF-less and 1.70 (1.11, 2.38) years in patients with SMuRFs. Conclusion Opium users not only undergo CABG at younger ages but also have a higher rate of mortality regardless of the presence of traditional CAD risk factors. Conversely, the risk of MACCE is only higher in patients with at least one modifiable CAD risk factor.
Towards More Efficient EfficientDets and Real-Time Marine Debris Detection

Marine debris is a problem both for the health of marine environments and for the human health since tiny pieces of plastic called “microplastics” resulting from the debris decomposition over the time are entering the food chain at any levels. For marine debris detection and removal, autonomous underwater vehicles (AUVs) are a potential solution. In this letter, we focus on the efficiency of AUV vision for real-time marine debris detection. First, we improved the efficiency of a class of state-of-the-art object detectors, namely EfficientDets [1], by 1.5% AP on D0, 2.6% AP on D1, 1.2% AP on D2 and 1.3% AP on D3 without increasing the GPU latency (see Fig. 1). Subsequently, we created and made publicly available a dataset for the detection of in-water plastic bags and bottles and trained our improved EfficientDets on this and on two public datasets for marine debris detection. Finally, we began the testing of real-time detection performance on a simulator of marine environments.
Perceived vs. observed mHealth behavior: A naturalistic investigation of tracking apps and daily movement

Research on mHealth apps provides mixed evidence regarding their effectiveness for behavior change, including physical activity. Synthesizing prior perspectives, we test predictors of tracking app and physical activity intentions (Study 1; n = 658) and their links to everyday mobility (Study 2; n = 418; n = 27,617,440 observations). Study 1 showed that individuals have overlapping perceptions of tracking apps and physical activity. Taking a naturalistic mobile sensing approach, Study 2 found that tracking app and physical activity intentions predicted self-reported physical activity – but not logged movement (i.e., walking, cycling, or running). Tracking app use was not related to the level of logged movement in daily life. However, participants who regularly used tracking apps were more likely to view them as impactful, suggesting that daily mHealth app use is related to perceived (vs. observed) behavior change. Together, our studies illuminate how perceptions of mobility and mobile media – and their effects – can become intertwined in users’ minds.
Discrete models for the p-local homotopy theory of compact Lie groups and p-compact groups

In our earlier paper [7], we defined and studied a certain class of spaces which in many ways behave like p ‐completed classifying spaces of finite groups. These spaces occur as “classifying spaces” of certain algebraic objects called p ‐local finite groups. The purpose of this paper is to generalize the concept of p ‐local finite groups to what we call p ‐local compact groups. The motivation for introducing this family comes from the observation that p ‐completed classifying spaces of finite and compact Lie groups, as well as classifying spaces of p ‐compact groups (see Dwyer and Wilkerson [11]), share many similar homotopy theoretic properties, but earlier studies of these properties usually required different techniques for each case. Moreover, while p ‐completed classifying spaces of finite and, more generally, compact Lie groups arise from the algebraic and geometric structure of the groups in question, p ‐compact groups are purely homotopy theoretic objects. Unfortunately, many of the techniques used in the study of p ‐compact groups fail for p ‐completed classifying spaces of general compact Lie groups. With the approach presented here, we propose a framework general enough to include p ‐completed classifying spaces of arbitrary compact Lie groups as well as p ‐compact groups. The new idea here is to replace fusion systems over finite p ‐groups, as handled in [7], by fusion systems over discrete p ‐toral groups. A discrete p ‐toral group is a group which contains a discrete p ‐torus (a group of the form .Z=p 1 / r for finite r 0) as a normal subgroup of p ‐power index. A p ‐local compact group consists of a triple
Dynamics and Global Stability of Beam-based Electrostatic Microactuators

We investigate the dynamics and global stability of a beam-based electrostatic microactuator, which is modeled as a first-order approximation of a reduced-order model (ROM) derived using the differential quadrature method (DQM). We show that the ROM dynamics is qualitatively similar to that of a higher-order approximation. We simulate the occurrence of dynamic pull-in for excitations near the first primary resonance using the finite difference method (FDM) and long-time integration. Limit-cycle solutions are obtained using the FDM, the generated frequency- and force-response curves exhibit cyclic-fold, saddle-node, and period-doubling bifurcations. We verify that symmetry breaking is not likely to occur because the orbit is already asymmetric. We identify the basin of attraction of bounded motions using various approximation levels. The simulations reveal that the erosion of the basin of attraction depends heavily on the amplitude and frequency of the AC voltage. We show that smoothness of the boundary of the basin of attraction can be lost and replaced by fractal tongues, which dramatically increase the sensitivity of the microbeam to initial conditions. According to these simulations, the locations of the two fixed points are likely to be disturbed.
NOTES AND CORRESPONDENCE On Quasigeostrophic Normal Modes in Ocean Models: Weakly Nonseparable Situation

This study examines quasigeostrophic Rossby eigenmodes of homogeneous as well as stratified oceans. Analytical studies of Rossby basin modes are usually done by using simple basin geometries. Simple means that solutions are available by applying a separation ansatz in looking for basin modes. Here the focus is on halftrapezoidal geometry, in particular on a stratified ocean with a half-trapezoidal (zonal) cross section. In this case, separation is not possible. However, approximate solutions can be found. Different approximations are discussed: one related to linearization of the boundary conditions, one related to a sight change in boundary geometry, and one that uses an asymptotic expansion. It is shown that the widely used ‘‘linearized boundary conditions’’ give wrong results for low-frequency modes. The reason is that weak asymmetries of the basin are neglected and wave energy is therefore distributed too homogeneously in the basin. Although the basin’s geometry used deviates only slightly from a square and the eigenvalue spectrum corresponds well with that of a square basin, eigenmodes can still differ greatly.
Geometric phases from stacks of crystal plates

Abstract With twisted stacks of N polarizers P or retarders R, the polarization of a light beam can be cycled around the Poincare sphere on N similar arcs of great P or small R circles. We calculate the phase changes around these cycles (geometric for P; geometric + dynamical for R). In the continuum limit N → ∞ of a smoothly twisting medium, a P stack forces the light to follow its changing polarization, and the phase is the solid angle of the associated loop on the sphere; for an R stack, on the other hand, it is only in the adiabatic limit of slow twist (where the dynamical phase is large) that the geometric phase corresponds to that of the loop specified by the changing eigenpolarization of the medium. The predicted phase shifts are observed as fringe shifts in an interferometer for N=2, 3 and 4.
Organic Bioelectronics Development in Italy: A Review

In recent years, studies concerning Organic Bioelectronics have had a constant growth due to the interest in disciplines such as medicine, biology and food safety in connecting the digital world with the biological one. Specific interests can be found in organic neuromorphic devices and organic transistor sensors, which are rapidly growing due to their low cost, high sensitivity and biocompatibility. This trend is evident in the literature produced in Italy, which is full of breakthrough papers concerning organic transistors-based sensors and organic neuromorphic devices. Therefore, this review focuses on analyzing the Italian production in this field, its trend and possible future evolutions.
A Simple Method for Obtaining Minimum Aberration Designs

Minimum aberration designs are preferred in practice, especially when it is desired to carry out a multi-factor experiment using less number of runs. Several authors considered constructions of minimum aberration designs. Some used computer algorithms and some listed good designs from the exhausted search. We propose a simple method to obtain minimum aberration designs for experiments of size less than or equal to thirty-two. Here, we use an ordered sequence of columns from an orthogonal array to design experiments and blocked experiments. When the method is implemented in MS Excel, minimum aberration designs can be easily achieved.
Analysis of 2‒D bimodular materials and wrinkled membranes based on the parametric variational principle and co‒rotational approach

In the numerical analysis of 2‒D bimodular materials, strain discontinuity is problematic, and the traditional iterative algorithm is frequently unstable. This paper develops a stable algorithm for the large‒displacement and small‒strain analyses of 2‒D bimodular materials and structures. Geometrically nonlinear formulations are based on the co‒rotational approach. Using the parametric variational principle (PVP), a unified constitutive equation is created to resolve the problem induced by strain discontinuity in the local coordinate system. Because the traditional stress iteration is not required, the local linear stiffness matrix does not need to be updated when computing the global stiffness matrix and the nodal internal force vector. The nonlinear problem is ultimately transformed into a complementarity problem that is simply solved by combing the Newton–Raphson scheme and the mature quadratic programming algorithm. Numerical examples demonstrate that the PVP algorithm presents better convergence behavior than the traditional iterative algorithm. By incorporating the concept of material modification, the new algorithm is also be successfully extended to the wrinkling analysis of thin membranes. Copyright © 2014 John Wiley & Sons, Ltd.
The ideal structure of the Stone-Čech compactification of a group

Let S be both a topological space and a semigroup. For s ∈ S, define the maps λs and ρs of S to S by We shall say that S is a right-topological (resp. left-topological) semigroup if ρs (resp. λs) is continuous for each s in S. We denote by Λ(S) the set this is a subsemigroup of S.
Probability model for peak fluxes of solar proton events

A predictive model of worst case, >10 MeV solar proton event peak fluxes is presented that fully accounts for the length of the space mission and the corresponding risk. Furthermore, the model predicts there is an upper limit which the peak flux can attain that is approximately twice the size of the largest observed peak flux to date. This is more restrictive than previous estimates of upper limits of solar proton event sizes that are based on historical evidence. It leads to a well-defined guideline for designing a space system that is radiation-hard against failures due to solar proton event peak flux effects. The model is based on a description of the solar proton event peak flux distribution obtained through application of the maximum entropy principle. This principle provides a mathematical basis for selecting the least biased distribution compatible with known information, and is especially useful for sets of data that are incomplete. The principle leads to a probability distribution that is a "truncated" power law. It behaves as a power law with an index of about -0.4 for 5-minute averaged peak fluxes less than about 10/sup 3/ cm/sup -2/ s/sup -1/ sr/sup -1/. The distribution decreases more rapidly than this for larger peak flux values, and goes to zero at a maximum value of 1.78/spl times/10/sup 5/ cm/sup -2/ s/sup -1/ sr/sup -1/. The theoretical distribution is in good agreement with satellite data dating back to 1967, which spans about 4 orders of magnitude in peak fluxes.
Congenital Microcephaly: A Debate on Diagnostic Challenges and Etiological Paradigm of the Shift from Isolated/Non-Syndromic to Syndromic Microcephaly

Congenital microcephaly (CM) exhibits broad clinical and genetic heterogeneity and is thus categorized into several subtypes. However, the recent bloom of disease–gene discoveries has revealed more overlaps than differences in the underlying genetic architecture for these clinical sub-categories, complicating the differential diagnosis. Moreover, the mechanism of the paradigm shift from a brain-restricted to a multi-organ phenotype is only vaguely understood. This review article highlights the critical factors considered while defining CM subtypes. It also presents possible arguments on long-standing questions of the brain-specific nature of CM caused by a dysfunction of the ubiquitously expressed proteins. We argue that brain-specific splicing events and organ-restricted protein expression may contribute in part to disparate clinical manifestations. We also highlight the role of genetic modifiers and de novo variants in the multi-organ phenotype of CM and emphasize their consideration in molecular characterization. This review thus attempts to expand our understanding of the phenotypic and etiological variability in CM and invites the development of more comprehensive guidelines.
AN ADDITIVE PROBLEM INVOLVING PIATETSKI-SHAPIRO PRIMES

Let Pr denote an almost-prime with at most r prime factors, counted according to multiplicity. In this paper it is proved that there exist infinitely many primes of the form p = [nc] such that p + 2 = Pr, where r is the least positive integer satisfying certain inequalities. In particular for $1 < c \leq \frac{30}{29} = 1.0344 \ldots$ we have r = 5. This result constitutes an improvement upon that of T. P. Peneva.
The Scale-Symmetric Physics

The vacuum field equations for the modified Higgs field are the most fundamental equations. The Kasner solution leads to virtual Higgs cyclones and virtual loops with toroidal and poloidal motions. Additional conditions lead to phase transitions of the modified Higgs field and quantization of the virtual Higgs cyclones which are free or overlap with the new structures. Due to the four succeeding phase transitions (their number is limited by the size of our Cosmos), there are in existence the four scales i.e. the superluminal- quantum-entanglement scale, luminal Planck scale concerning the Einstein-spacetime components, observed-particles scale and cosmological scale. Due to the quantum entanglement, there as well appear virtual cyclones and virtual loops in the Einstein spacetime. The negative pressure and characteristic motions (and the quantum entanglement) in the virtual structures cause that there appears the advection that rules the motions of matter. It leads to the "dark-matter" motions i.e. to the spin speeds of normal cold matter in galaxies almost independent from distances from the centers of galaxies. The dark energy consists of the additional Einstein-spacetime components which appeared due to the phenomena associated with the cosmological scale. The Feigenbaum constant delta follows from the internal structure of proton so this structure leads to the chaos theory. We can see the sequence: from vacuum field equations, via Kasner solution, to the virtual Higgs cyclones and loops, to phase transitions of the modified Higgs field, to quantum entanglement which via the virtual structures in the Einstein spacetime leads to the "dark-matter" motions. The chaos theory concerns particle physics and cosmology. The quantum physics appears on higher level of Nature. 1. The vacuum field equations for the modified Higgs field are the most fundamental equations Assume that we start from non-zero-volume, totally transparent points (the points of nothingness) and non-zero-volume, moving, totally non-transparent points (the gravitationally massless and internally structureless pieces of space). The pieces of space can stick together so in the infinite volume are in existence very big pieces of space as well. Assume that there was non-central collision of very big pieces of space and/or they rotated. The very big pieces of space cracked into very small pieces of space. We can define their mean size, mean linear speed and mean angular speed. In our Cosmos, the total rotational energy of the very small pieces of space is about 54 powers of ten smaller than the kinetic energy but it causes that the created vortices have internal helicity. At the beginning of the inflation of the cracked very big pieces of space there was the liquid composed of the moving
High power microwave generation by a coaxial virtual cathode oscillator

A new type of virtual cathode oscillator, the coaxial vircator, was studied analytically and experimentally. A one-dimensional analytical model was used to describe the steady-state behavior of the electron beam and the virtual cathode, from which the diode current, the space-charge limited current, the virtual cathode position, and the estimated oscillation frequency were obtained. The experiments were carried out with typical electron-beam parameters of 500 kV, 40 kA, and 30 ns, where pulsed microwaves of 400 MW in peak power and 2 GHz in frequency have been obtained. The energy efficiency from the electron beam to microwaves was /spl sim/2%. This efficiency is expected to be improved by increasing the microwave field strength around the vircator.
Approaches for Selective Vaccinations in Cirrhotic Patients

Bacterial and viral infections are common in cirrhotic patients, and their occurrence is associated with the severity of liver disease. Bacterial infection may increase the probability of death by 3.75 times in patients with decompensated cirrhosis, with ranges of 30% at 1 month and 63% at 1 year after infection. We illustrate the indications and the modalities for vaccinating cirrhotic patients. This topic is important for general practitioners and specialists.