Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive Model for Dynamic and Temporal Topic Modeling from Big Data using Deep Learning Architecture

—Due to freedom to express views, opinions, news, etc and easier method to disseminate the information to large population worldwide, social media platforms are inundated with big streaming data characterized by both short text and long normal text. Getting the glimpse of ongoing events happening over social media is quintessential from the viewpoint of understanding the trends, and for this, topic modeling is the most important step. With reference to increase in proliferation of big data streaming from social media platforms, it is crucial to perform large scale topic modeling to extract the topics dynamically in an online manner. This paper proposes an adaptive framework for dynamic topic modeling from big data using deep learning approach. Approach based on approximation of online latent semantic indexing constrained by regularization has been put forth. The model is designed using deep network of feed forward layers. The framework works in an adaptive manner in the sense that model is extracts incrementally according to streaming data and retrieves dynamic topics. In order to get the trends and evolution of topics, the framework supports temporal topic modeling, and enables to detect implicit and explicit aspects from sentences also.
Inventory Risk and Dealer Competition in a Dealer Network∗

We develop an inventory model of bidding and trading through a dealer network in over-the-counter markets. In the model upon arrival of a customer’s order, dealers first bid against each other for the order, and then engage in bilateral trading to smooth inventory imbalances. We analyze and characterize the equilibrium for a general dealer network. We then focus on star networks to illustrate the competition between the peripheral dealer who has the best inventory position and the central dealer who has the best connectivity that allows him to better disperse the customer’s order among other dealers. In sharp contrast with the existing inventory literature, we find that due to centrality the central dealer may still be in the best position to absorb the customer’s sell (buy) order even though he has the largest (smallest) inventory across all dealers. (JEL Classificaiton: D81, D85, G11, G12)
Association between serum chemerin level and severity of coronary artery disease in Egyptian patients with type 2 diabetes

The objective of this study was to assess the relationship between serum chemerin level and the severity of coronary artery disease (CAD) in Egyptian patients with type 2 diabetes T2DM. The study included 160 subjects; divided into 4 equal groups; T2DM patients having CAD, CAD patients without diabetes, T2DM patients without CAD and a healthy control group. Serum chemerin level, and hs-CRP were measured and the severity of CAD was assessed using SYNTAX score. Serum chemerin was significantly higher in patients with CAD (p<0.001), with no difference however between diabetic and non-diabetic subjects (p= 0.16). Our results showed a significant positive correlation between serum chemerin and waist circumference (p=0.024) as well as waist to hip ratio (p=0.044). A significant association has been observed between the severity of CAD and each of serum chemerin (p <0.001) and hs-CRP (p =0.04). We report here a positive correlation between serum chemerin level and cardio-metabolic disease, with a significant association between serum chemerin concentration and severity of CAD in Egyptian patients with T2DM.
Jasmonic acid induces stabilization and nuclear localization of ORA59, an AP2/ERF-domain transcription factor essential for defense responses in Arabidopsis

Plant defense against pathogens and herbivores depends on the action of several endogenously produced hormones, including jasmonic acid (JA) and ethylene. In certain defense responses, JA and ethylene signaling pathways synergize to activate a specific set of defense genes. The AP2/ERF-domain transcription factor ORA59 acts as the integrator of the JA and ethylene signalling pathways. How JA and ethylene affect the activity of ORA59 is not known. The aim of the studies reported here was to determine whether JA has an activating effect on ORA59 at the protein level. The results show that JA caused stabilization as well as nuclear localization of ORA59. Domain mapping of ORA59 showed that stabilization and nuclear localization were conferred by more than one single domain. Interestingly, nuclear localization of ORA59 did not require a functional COI1 protein. We postulate that there is a jasmonate receptor distinct from COI1, an F-box protein that targets ORA59 for degradation, and a repressor protein that keeps ORA59 in the cytoplasm.
A Review on Pharmacotherapy of P2Y12 Receptor Inhibitor (Ticagrelor)

Ticagrelor is an antiplatelet agent with a mechanism of a direct and reversible competitive inhibition of P2Y12 receptor. According to European Cardiac society, Ticagrelor is used for prevention of thrombotic events in acute coronary syndromes. Until recently, a combination of clopidogrel and aspirin was acknowledged as a gold standard of the antiplatelet treatment. Now ticagrelor is preferred over clopidogrel, This review is mainly looking upon major aspects of ticagrelor. They are Pharmacokinetics, pharmacogenetics, drug-drug interactions, adverse effects, efficacy in specific patient populations and offlabel properties of ticagrelor are discussed in this paper. Moreover, the results from pivotal clinical trials are presented. Suganthi S*, Charumathi A, Babisha J, Sathish kumar R, Sankar C, Suresh Kumar R Department of Pharmacy Practice, KMCH college of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore641048, Tamil Nadu, India (Affiliated to The Tamil Nadu Dr. M.G.R. Medical University). Submission: 26 August 2019 Accepted: 31 August 2019 Published: 30 September 2019 www.ijppr. humanjournals.com Citation: Suganthi S et al. Ijppr.Human, 2019; Vol. 16 (2): 353-368. 354
PII: S1389-9457(01)00078-8

Objective: To evaluate the psychometric properties of the DBAS-10, a recently proposed abbreviated version of the Dysfunctional Beliefs and Attitudes About Sleep Scale (DBAS). Population: Two hundred and eleven (69 normal sleepers; 142 insomnia suffers) middle-aged and older adults (age 40–79 years) drawn from two separate cohorts of research volunteers. Method: Volunteers in the first cohort (69 normal sleepers; 69 insomnia sufferers) completed the full DBAS on one occasion. Volunteers in the second cohort (73 insomnia sufferers) completed the full DBAS prior to treatment and at multiple subsequent time points to assess treatment-related changes. A series of statistical tests were conducted with one or both cohorts to investigate the comparability of the DBAS-10 and full DBAS, the internal consistency of each instrument, the factor structure of the DBAS-10, and the validity of this instrument. Results: Statistical findings showed that the DBAS-10 correlated highly with the full DBAS, had respectable internal consistency, effectively discriminated normal sleepers from insomnia sufferers, and detected cognitive changes resulting specifically from CBT intervention. Although factor analysis empirically identified three conceptually meaningful DBAS-10 subscales, the subscale structure varied somewhat from previous factor analytic findings with this instrument. Conclusions: The DBAS-10 generally appears to have very acceptable psychometric properties although subscales previously proposed for this instrument may vary across research populations. Nonetheless, results encourage the use of this instrument in studies concerned with the nature and treatment of sleep-disruptive cognitions. q 2001 Elsevier Science B.V. All rights reserved.
Diagnostic markers for community-acquired pneumonia

Community-acquired pneumonia (CAP) is one of the respiratory infectious diseases caused by not only bacteria, but also viruses. Antibiotic agents are needed to treat only bacterial but not viral CAP. In addition, there are some non-infectious respiratory diseases in the differential diagnosis of CAP, such as malignant diseases, interstitial lung diseases, pulmonary edema, and pulmonary hemorrhage. We usually diagnose patients having CAP by comprehensive evaluation of symptoms, vital signs, laboratory examinations, and radiographic examinations. However, symptoms and vital signs are not specific for the diagnosis of CAP; therefore, we also use inflammatory biomarkers for differentiating bacterial from viral CAP and non-infectious respiratory diseases. We have used the white blood cell count, C-reactive protein (CRP), and erythrocyte sedimentation rate as common inflammatory biomarkers, but they are not specific for bacterial infection because they could be increased by malignant diseases and collagen diseases. Recently, some inflammatory biomarkers such as procalcitonin (PCT), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), pro-adrenomedullin (proADM), and presepsin have been developed as relatively specific biomarkers for bacterial infection. Many reports have evaluated the usefulness of PCT for diagnosing CAP. In this review, the characteristics of each biomarker are discussed based on previous studies.
The Rise of Passive Funds Triggers Active Fund Consolidation

Consolidation among asset managers surged in 2016. What triggered this new wave of consolidation? Through a noisy rational expectation model with imperfect competition, we show that the rise of passive funds could attribute to the new change. As the size of passive funds grows, the market becomes more liquid. As a result, the rents extracted from noise traders shrinks and the competition among active funds becomes severer. These effects squeeze down the expected profit margins of active funds, hence stimulating them to form a coalition to gain monopolistic trading power. The rise of passive funds affects market outcomes (liquidity, price informativeness and volatility) both directly and indirectly through fund consolidation. The aforementioned two mechanisms have competing effects. Hence it is essential to control for fund consolidation when examining the (casual) relationship between passive funds and market outcomes.
U-shaped Relationship between Investment and Cash flows: Panel Data Evidence from Indian Manufacturing Firms* Dr. SUCHETA GAUBA

The past decades have seen the growth of various countries from unknown to known, “under-developed” to “developed” and some still developing. Investment being the backbone of any growing economy has attracted the researchers worldwide. Since the seminal article of Modigliani and Miller (MM) in 1958, a number of researches have been carried out to understand the interaction of investment, financing and dividend decisions. Ironically, a large number of studies undertaken with Modigliani and Miller (MM) as a base have shown a divergence in results from MM‟s results. The present study empirically examines the existence of a non-monotonic relationship between investment and cash flow. Panel data model with balanced dataset has been estimated for a sample of 176 large sized Indian companies for 1994-95 to 200809. A square and cubic term of cash flows has been included in investment equation to capture U-shaped relationship. The investment and internal funds (cash flows) have been found to have a U-shaped relationship. These findings are consistent with the Ushaped investment curve introduced by Cleary et al (2006).
Coffea arabica cultivars with resistance to nematode Meloidogyne exigua originated from Costa Rica

The nematode Meloidogyne exigua causes moderate losses in almost all coffee plantations in Costa Rica. The objective of this research was to evaluate the resistance of Coffea arabica cultivars developed in Brazil to M. exigua native from Costa Rica. The trial was carried out in Heredia, Costa Rica. A randomized complete block design with five replications was used to evaluate the cultivars Caturra, Catuaí Vermelho IAC 99, IAPAR 59, IPR 98, IPR 99, IPR 100, IPR 102, IPR 103, IPR 106 and IPR 107. The plants were grown in pots and inoculated with 2500 eggs + J2 117 d after the transplant. The evaluation was performed 209 d after the inoculation considering the number of eggs + J2 in 100 g of roots and the estimation of gall index (GI) of each plant. The reduction in the reproduction factor showed resistance for the cultivars IPR 99, IPR 100, IPR 102, IPR 103 and IPR 107. This represents a great possibility to face M. exigua of Costa Rica in a sustainable way with varieties developed in Brazil.
Investment Banker Directors and Capital Raising Activities*

Using a large hand-collected data set of investment bankers (IB) on corporate boards, we examine whether and how IB directors affect capital raising and corporate policies. We find that firms with IB directors have a higher probability of making seasoned equity offerings (SEOs), and such offerings are associated with higher announcement returns and lower issuance costs. Post-SEO, issuers with IB directors invest more, hold less cash, and experience better operating and stock performance. Our channel analysis suggests that IB directors reduce information asymmetry between issuers and the capital market. Overall, our results highlight the advisory role of specialist directors.
Market News and Financial Information Disclosure

We empirically examine how market news affects firms’ timeliness of financial information disclosure. Opposite to the theoretical prediction of Acharya, DeMarzo, and Kremer (2011), we find that good market news accelerates while bad market news decelerates the releases of financial reports. This influence of market news is especially pronounced for the bad earnings firms. Our study also suggest that the effect of market news on firms’ timeliness is bigger than those of well-studied firm news.
Capital structure around the S&P 500 index additions: Evidence of window dressing

We examine the capital structure of firms that are newly added to the S&P 500 index. Leverage gradually decreases during the two-year pre-addition period and then increases during the two-year post-addition period. This trend is attributable to debt issuance and cannot be explained by mechanical effects. We explain these findings as corporate window-dressing efforts to increase the probability of being added to the index. Consistent with this explanation, the leverage trend is more pronounced in financially weak firms and firms facing intense competition for addition to the index. The post-addition reversion of leverage is consistent with the existence of a target capital structure.
Comparative genomics reveals bamboo feeding adaptability in the giant panda (Ailuropoda melanoleuca)

Abstract The giant panda (Ailuropoda melanoleuca) is one of the world’s most endangered mammals and remains threatened as a result of intense environmental and anthropogenic pressure. The transformation and specialization of the giant panda’s diet into a herbivorous diet have resulted in unique adaptabilities in many aspects of their biology, physiology and behavior. However, little is known about their adaptability at the molecular level. Through comparative analysis of the giant panda’s genome with those of nine other mammalian species, we found some genetic characteristics of the giant panda that can be associated with adaptive changes for effective digestion of plant material. We also found that giant pandas have similar genetic characteristics to carnivores in terms of olfactory perception but have similar genetic characteristics to herbivores in terms of immunity and hydrolytic enzyme activity. Through the analysis of gene family expansion, 3752 gene families were found, which were enriched in functions such as digestion. A total of 93 genes under positive selection were screened out and gene enrichment identified these genes for the following processes: negative regulation of cellular metabolic process, negative regulation of nitrogen compound metabolic process, negative regulation of macromolecule metabolic process and negative regulation of metabolic process. Combined with the KEGG pathway, it was found that genes such as CREB3L1, CYP450 2S1, HSD11B2, LRPAP1 play a key role in digestion. These genes may have played a key role in the pandas’ adaptation to its bamboo diet.
Distribution of Rare Earth Elements in the Metamorphic Rocks of the Paleoproterozoic Nyong Unit (Congo Craton, South – Cameroon)

We reported for the first time the geochemistry of rare earth elements (REE) for the metamorphic rocks of the Paleoproterozoic Nyong unit situated at the west of Congo craton in Cameroon. Rare earth elements, define a group of fifteen chemical elements from lanthanum to lutetium (atomic numbers 57-71) characterized by similar chemical properties. To study their distribution in the metamorphic rocks of the Nyong unit, 24 representative samples were selected. The selected samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Rocks are strongly enriched in REE (especially LREE) and these rare earths set up a complex group. The abundance of REE suggests the presence of REE-rich minerals such as monazite and this monazite should be rich in LREE (La, Ce, Nd, Sm). The variations of the REE fractionation in the studied rocks is explained by different degrees of partial melting of the protolith and by variable enrichment of the source. REE concentrations in the rocks were of geogenic origins and not influenced by anthropogenic sources. LREE enrichment result in geochemical distribution of these elements in the area and good correlation between them. The unusually high contents of REE and unusually high contents of light rare earths enrichment compared to heavy rare earths is highlighted in biotite-gneisses, garnet-micaschists and garnet charnockitic gneisses. Chondrite normalization patterns are parallel; they show high LaN/YbN ratios which reflect highly fractioned REE compositions displaying a W-profile and a strong Eu anomaly for meta-igneous unit; zigzag-profile with a marked negative Ce anomaly and a pronounced positive Eu anomaly for metasediments. REE residence includes major minerals (feldspar, garnet, amphibole, biotites, clinopyroxene, epidote) and accessory minerals (phosphates such as monazite). The REE of Edea region can be economically exploitable. Keywords— Rare earth elements, Paleoproterozoic Nyong unit, Congo craton, major minerals, accessory minerals.
DMSO_A_190752 1419..1436

Kfir Lapid 1,2 Ajin Lim Eric D Berglund Yue Lu 1Department of Developmental Biology, 2Division of Endocrinology, Department of Internal Medicine, 3Advanced Imaging Research Center, 4Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA Background: Low estrogen states, exemplified by postmenopausal women, are associated with increased adiposity and metabolic dysfunction. We recently reported a paradox, in which a conditional estrogen receptor-alpha (ERα) mutant mouse shows a hyper-metabolic phenotype with enhanced brown/beige cell formation (“browning/beiging”). Hypothesis: These observations led us to consider that although systemic deficiency of estrogen or ERα in mice results in obesity and glucose intolerance at room temperature, cold exposure might induce enhanced browning/beiging and improve glucose metabolism. Methods and results: Remarkably, studying cold-exposure in mouse models of inhibited estrogen signaling ERαKO mice, ovariectomy, and treatment with the ERα antagonist Fulvestrant supported this notion. ERα/estrogen-deficient mice demonstrated enhanced coldinduced beiging, reduced adiposity and improved glucose tolerance. Fulvestrant was also effective in diet-induced obesity settings. Mechanistically, ERα inhibition sensitized cell-autonomous beige cell differentiation and stimulation, including β3-adrenoreceptor-dependent adipocyte beiging. Conclusion: Taken together, our findings highlight a therapeutic potential for obese/diabetic postmenopausal patients; cold exposure is therefore predicted to metabolically benefit those patients.
Population Assessment Update for Sakhalin Gray Whales, with Reference to Stock Identity

The population assessment of gray whales Eschrichtius robustus feeding off Sakhalin and Kamchatka is updated, using a population model that alows for multiple feeding and breeding areas. The model is fit to photo-id data collected of Sakhalin during 1995-2015 (Burdin et al. 2015), tracking of whales from Sakhalin to the eastern North Pacific (Mate et al. 2015), photo-id matches of gray whales between the Sakhalin and Mexico catalogues (Urbán et al. 2013) and reported photo-id results from Kamchatka collected during 2004-12 (Yakovlev et al. 2013),. The results show that the Sakhalin and Kamchatka feeding populations have been increasing at 2-5% per year over the 10 or 20 years to 2015. The number of non-calf whales in 2016 is estimated to be 320−410, of which 130−170 are predominantly Sakhalinfeeding whales or 180−220 are whales that feed at least occasionally off Sakhalin. A test of the population model output against the results of a paternity analysis by Lang (2010) just rejects the hypothesis of genetic closure of the Sakhalin feeding population (p < 0.05) but does not reject the hypothesis of genetic closure of the Sakhalin and Kamchatka feeding populations combined. Of the predominantly Sakhalin-feeding whales, an estimated 0-50 belong to a possible relict western North Pacific breeding population (which may or may not be genetically closed). Using the IUCN Red List criteria, the Sakhalin and Kamchatka populations, if assessed as a subpopulation, either separately or together, would be classified as Endangered, on the basis of there being between 50 and 250 mature individuals (i.e. ~100-500 individuals when juveniles but not calves are included). If the relict western North Pacific breeding population were assessed as a subpopulation, it would be classified as Critically Endangered, on the basis of there being less than 50 mature individuals.
Know your HIV Epidemic (KYE) in Somali Region, Ethiopia

Background: In 2016, an estimated 718,500 of people living with HIV and about 19,743 AIDS related deaths has occurred in Ethiopia. The current national HIV/AIDS strategic plan [2015-2020] capitalizes on implementing targeted prevention interventions to reach those at risk and vulnerable population groups and preparing district based epidemiologic synthesis using routine data. Methods: Know Your Epidemic (KYE) method was used to come up with know your epidemic synthesis. Primary and secondary data also used for triangulation of the synthesis in order to identify an updated picture of the HIV epidemic and its drivers of epidemic in Somali region, Ethiopia. The study was conducted in Somali region between May to August 2017. Result: HIV epidemic scenario in Somali region is relatively low (0.75%) in prevalence according to 2017 EPHI projection. However, it is more heterogeneous among zones, ranges from 6.88% in Sitti zone to 0% in many zones in Somali region, and even more heterogeneous between districts, ranging from 18.86% in Dekasuftu to 0% in many districts. It also various among settings: rural (3.8%) highest figure nationally and Urban (3.5%) according to ANC sentinel surveillance. Majority of the data shows increasing HIV prevalence trends in Somali region over time in both sex groups. Somali region has responded the diseases both institutionally and program levels, which is more centralized. Conclusions: The overall HIV prevalence in Somali region, Ethiopia is relatively low (0.75%, 2016 EPHI) but more varied significantly among zones and districts.