Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcome of acute heart failure hospitalizations and its associates in a teaching hospital in Makurdi, North Central Nigeria

Heart failure is the end stage of most heart diseases affecting millions of people worldwide with high mortality rate and enormous financial burden. This economic burden is largely attributed to high rates of short term and frequent hospitalization. The aim of our study is to determine the associates of inhospital mortality and short term rehospitalisation in our centre. This was a hospital based retrospective cohort study. The case records of patients admitted for acute heart failure at the medical wards of Benue State University teaching Hospital Makurdi were used to obtain demographic, clinical, laboratory and electrocardiographic records. Echocardiographic records were obtained from case notes and echo records. Inhospital mortality and rehospitalisation records were obtained from case notes. Pearson chi-square was used to determine the associates of the outcome. There were 76 subjects with 44(57.9%) males and 32(42.1%) females. The mean age of the population was 52.37±13.46 years. The inhospital mortality rate was 7.9% while the short term rehospitalisation rate was 17.1%. There were significant associations between inhospital mortality and heart failure with preserved ejection fraction (χ = 6.877; p = 0.009) and anaemia (χ = 7.717; p = 0.005). There was significant association between age and short term rehospitalisation (χ = 4.141; p = 0.042). The inhospital mortality rate obtained in our study is comparable to other African studies. Close attention should be paid to patients with heart failure with preserved ejection fraction, anaemia, elderly patients and treatment of comorbidities in the management of heart failure.
SOCIAL SUPPORT AND SUCCESSFUL AGING: AN INTERGENERATIONAL COMPARISON

The objective of the present study is to find out the intergenerational similarities and differences in social support and successful aging in joint families. The current research is based on a survey design in which data was collected from three generations (grandparents, fathers, mothers, grandchildren) living together. The final sample comprised 1080 participants with a distribution of 270 grandparents, 270 fathers, 270 mothers, and 270 grandchildren. Social support was assessed by using the MacArthur Battery of Social Support with four dimensions, including received emotional support, received instrumental support, perceived demand and criticism, and provided support. In contrast, successful aging was assessed by using the Successful Aging Scale. Findings show a strong positive relationship between received emotional support, received instrumental support, perceived demand, and criticism, and provided support and successful aging of grandparents, fathers, mothers, and grandchildren. Results also indicate significant mean differences in study variables except for instrumental support for grandparents, fathers, mothers, and grandchildren. Multi-group analysis revealed pairwise comparison for the modeled path. Findings show fathers receive greater emotional support and have better successful aging; both fathers and mothers reported greater provided support, whereas grandchildren reported receiving greater demand and criticism than other groups.
ISC6 template

Results from piezocone tests in soft lacustrine clay at the national geotechnical experimentation site (NGES) at Northwestern University are used to interpret effective friction angle, rigidity index, undrained shear strength, and yield stress ratio (YSR) with depth. The effective friction angle is evaluated using an effective stress limit plasticity solution derived by the Norwegian Institute of Technology (NTH). A hybrid spherical cavity expansion – critical state soil mechanics (SCE-CSSM) framework provides the undrained rigidity index (IR) based on cone tip resistance and porewater pressure readings. The evaluated IR is utilized in evaluating three separate formulations for YSR from SCECSSM in terms of net cone resistance, excess porewater pressure, and effective cone resistance. These three profiles fully agree and match with laboratory reference values obtained from standard consolidation tests on undisturbed samples. Finally, the method gives good agreement with lab-measured undrained shear strengths from CAUC tests using the corresponding cone bearing factor obtained from the acquired value of IR.
Interaction Dynamics of Arbitrage, Hedging and Speculation with Spot Volatility: Evidence from Crude Oil Market

our findings. Our results confirm that different trading activities - arbitrage, speculation and hedging are interlinked and its extent varies across different markets and the results are in line with the views of Working (1960). It is observed that lagged volatility and speculation have a positive impact on spot market volatility supporting Master’s hypothesis, while the impact of hedging and arbitrage is lower except for Europe where arbitrage also increases volatility. Overall, spot Market volatility is explained by speculation and arbitrage, while the role of hedging is diminished.
The Effect of Cutibacterium acnes Infection on Nerve Penetration in the Annulus Fibrosus of Lumbar Intervertebral Discs via Suppressing Oxidative Stress

Modic changes (MCs) and low back pain are highly correlated and an economic burden to the society. Previous studies have shown that Cutibacterium acnes (C. acnes) infection can lead to MCs. The purpose of this study was to clarify whether and how C. acnes contributes to oxidative stress and nerve growth that potentially leads to low back pain. Neurons from the hippocampus or dorsal root ganglion (DRG) of Sprague-Dawley (SD) rats were cocultured with annulus fibrosus cells (AFCs) with or without the presence of the C. acnes supernatant in vitro. Cell viability, neurite length, oxidative stress, and neuro-related gene expression were examined. Furthermore, samples from the patients with MCs and SD rat model of MCs were used to validate the nerve growth results. Neurons from both the hippocampus and DRG showed neurites when cocultured with AFCs in the environment with/without the C. acnes supernatant. The average neurite length was significantly longer when exposed to the C. acnes supernatant in the hippocampal neuron (217.1 ± 90.0 μm versus 150.1 ± 68.1 μm in the control group) and in the DRG neuron (229.1 ± 91.3 μm versus 149.2 ± 64.8 μm in the control group). Hippocampal neurons showed upregulated expression levels of NeuN, Map2, and Psd95, while upregulation was only seen in Tuj-1 in DRG neurons. Suppressed oxidative stress could be observed using axon growth symbols. Degenerated disc structures and abnormal bone remodelling were found in animal models and clinical samples of MCs, with astrocytes, microglia, and neurons in the disc. Therefore, C. acnes infection was found to cause back pain in the presence of MCs by promoting nerve penetration into the annulus fibrosus by suppressing oxidative stress.
Investment in ESG Projects and Corporate Performance of Multinational Companies

This study investigates whether investing in environmental, social, and governance (ESG) projects boosts corporate financial performance. It also examines whether these projects trigger the company’s default due to the high costs of such projects, depending on whether the firm is multinational and its headquarter region. To obtain robust results, we conduct the examination separately for seven regions: North America, Latin America, Western Europe, Eastern Europe, Middle East and Africa, emerging Asia, and Developed Asia. We examine firm-level indicators of 1,249 companies and are headquartered in different regions for 2011-2019. We find that the company’s headquarter region influences the interrelationship between financial performance and ESG activities. The most successful companies in ESG development are international companies and those headquartered in developing or Developed Asia or North America. Meanwhile, Latin American firms, both local and multinational, experience significant challenges during the implementation of ESG initiatives.
ANALISIS PENGARUH EARNING PER SHARE, HARGA EMAS DUNIA, INFLASI TERHADAP HARGA SAHAM PERUSAHAAN SEKTOR PERTAMBANGAN DI BURSA EFEK INDONESIA PADA MASA PANDEMI COVID-19

This study aims to determine the simultaneous and partial effect of earnings per share, world gold prices, inflation on share prices of mining sector companies on the Indonesia Stock Exchange during the Covid-19 pandemic. The population in this study there are 47 mining sector companies listed on the Stock Exchange using purposive sampling method in sampling. Researchers set certain criteria in taking research samples and obtaining 32 companies as samples. This research was conducted during the Covid-19 pandemic during 2020. The data collection technique in this study used the documentation method by studying the company's financial statement records, stock price data, world gold price data, and inflation. The data analysis method in this study used multiple linear regression analysis with SPSS 25 program. The results showed that in the F-test simultaneously earning per share, world gold prices, inflation had a significant effect on stock prices of mining sector companies on the Indonesia Stock Exchange during the Pandemic. Covid-19. Meanwhile, the t-test results show that partially earnings per share (EPS) has a significant effect on the share price of mining companies on the Indonesia Stock Exchange during the Covid-19 pandemic. On the other hand, partially world gold prices and inflation have no significant effect on share prices of mining sector companies on the Indonesia Stock Exchange during the Covid-19 pandemic.
Optimization of ship degaussing system by using multi-population PSO

Now common adjustment methods of degaussing system are concerned with a ship′s magnetic field but seldom refer to its magnetic gradient.In order to improve its magnetic silence perfor-mance,the attenuation of both its magnetic field and gradient should be taken into account.In this case,the current optimization problem is treated as a multi-objective optimization problem.In order to solve this problem,it is necessary to calculate a set of scale factors by optimizing the two different objective functions according to the multi-population particle swarm optimization(M-PSO) so as to obtain the two kinds of objective function.Then the multi-objective optimization is transformed to a single objective optimization via a set of proper weights so that M-PSO can solve the problem.Finally,a typical ship degaussing system is used to test the method.The results show that both the ship′s magnetic field and its gradient can be attenuated.
A Patient with Severe Fever with Thrombocytopenia Syndrome (SFTS) Infected from a Sick Dog with SFTS Virus Infection.

Severe fever with thrombocytopenia syndrome (SFTS) caused by Dabie bandavirus (formerly SFTS virus, SFTSV), which belongs to the Bandavirus genus (formerly Phlebovirus genus) of the Phenuiviridae family (formerly Bunyaviridae family) is a tick-borne novel bunyavirus infection with high case fatality. A 4-year-old dog sickened with symptoms of lethargy and anorexia was diagnosed as having SFTSV infection virologically in western Japan in June 2017. The dog's owner, a man in his 40s, had taken care of the sick dog and became sick 10 days after disease onset in the dog, showing symptoms such as fever, arthralgia, headache, and nausea and vomiting. Total blood cell counts revealed leukocytopenia and thrombocytopenia. He was treated on an outpatient basis. He had no scars suggesting that he had been bitten by tick and was diagnosed as having SFTS by detection of IgM and neutralizing antibodies to SFTSV. The patient was infected with SFTSV directly from the SFTSV-infected dog. Humans can be at risk of SFTSV infections through direct contact with sick dogs infected with SFTSV.
Antibacterial activity of cannabis extract (Cannabis sativa L. subsp. indica (Lam.)) against canine skin infection bacterium Staphylococcus pseudintermedius

Superficial bacterial skin infections caused by Staphylococcus pseudintermedius are common in dogs. The cannabis plant has shown potential antibacterial effects, but there is limited information about anti-S. pseudintermedius activity. This study investigated the antibacterial activity of the ethanolic extract and the topical formulations of Cannabis sativa L. subsp. indica (Lam.) against 23 S. pseudintermedius isolates obtained from canine pyoderma using broth microdilution and time-kill assays. The cannabis extract’s minimum inhibitory concentrations for 50% (MIC50) and 90% (MIC90) of the tested S. pseudintermedius isolates were 6.25 and 12.50 μg/ml, respectively. The MIC for S. pseudintermedius ATCC 49051 was 6.25 μg/ml. The time-kill test revealed that the bactericidal effect of the cannabis extract was timeand not concentration-dependent. Topical formulations containing 0.5, 1, 2, 5, and 10% w/w cannabis extract showed limited in vitro antimicrobial activity in the time-kill test. Only the formulations with cannabis extract of 10% and 5% w/w could reduce the number of viable S. pseudintermedius ATCC 49051 by more than 3-log10 (99.9%) at 6 and 24 h, respectively. This study demonstrated that the cannabis extract has a good potential to be developed as an antibacterial agent against S. pseudintermedius. However, a clinical trial should be conducted to determine its in vivo therapeutic efficacy.
Comparative evaluation of psychopharmacotherapy of atypical depression in bipolar and recurrent affective disorder, psychogenic depression

Objective: to evaluate the treatment effectiveness for atypical depression (AtD) depending on its nosology: in bipolar affective disorder (BAD), recurrent depressive disorder (RDD) and psychogenic depression (PD). Patients and methods. A total of 250 patients with depression were screened, of which 77 patients with symptoms of AtD were enrolled in the study, 35 of them with BAD, 18 with RDD, and 24 with PD. Patients in all three groups received an antidepressant (AD) or a mood stabilizer (MS) monotherapy, or a combination of AD and antipsychotic (A), AD and A, MS and A, as well as a combination of AD, A and MS. The patients' condition was assessed clinically using a specially designed questionnaire and MADRS and CGI scales at the baseline and the 2nd, 3rd, 4th, 6th, 12th weeks of treatment. Quality of life satisfaction was assessed with the Q-LES-Q-SF (Scoring the Quality-of-Life Enjoyment and Satisfaction Questionnaire) scale at the treatment onset and after the 12th week of treatment.Results and discussion. Treatment regimens that included AD were the most eff in all groups of patients with AtD. The proportion of responders among those who received AD for bipolar disorder (75% or more) was significantly higher than among those who did not receive it (˂50%). In the RDD and PD groups, patients responded significantly better to AD monotherapy (RDD – 93.2%; PD – 91.5%) compared to other regimens. Agomelatine was the most frequently used (31.8%) and effective AD in all groups. Also, escitalopram, vortioxetine, and venlafaxine (p˂0.05) showed high efficacy, good tolerance, and absence of side effects that aggravate the main symptoms that characterize AtD. Among the antipsychotics in combination with AD, sulpiride was significantly more effective in patients with PD (p˂0.05). The highest rates of quality of life satisfaction were achieved in the BAD group, the lowest – in patients with PD (p˂0.05), which indirectly indicates the quality of remission, which is determined not only by the degree of reduction of depressive symptoms but also by the patients' subjective perception of their mental state.Conclusion. The inclusion of AD in the AtD treatment regimen significantly increases its effectiveness in patients of all groups, including BAD. AtD treatment should be administered not only taking into account its clinical signs and severity, but also depending on the nosology of the disease, the characteristics of its course. During drug administration, it is necessary to consider the spectrum of side effects, especially those that increase the symptoms of AtD itself.
Benefits of nostalgia in vulnerable populations

ABSTRACT The COVID-19 pandemic has triggered and exacerbated psychological distress, and exposed psychological vulnerabilities, in large swathes of the population. Under challenging circumstances, nostalgia may convey tangible psychological and physical health benefits. We review recent evidence for nostalgia’s utility in vulnerable populations, including sojourners and immigrants, civil war refugees, people suffering bereavement, people facing a limited time horizon, and people living with dementia. Having raised the prospect of a positive role for nostalgia in responding to adversity, we next present findings from a series of randomised nostalgia interventions and their impact over time in the workplace, during the COVID-19 pandemic, and at university, respectively. We conclude by offering evidence-based recommendations for future interventions, highlighting the importance of optimal person-activity fit, diversity of content, and accessibility of delivery mechanisms.
Sitagliptin Attenuates the Cognitive Deficits in L-Methionine-Induced Vascular Dementia in Rats

Vascular dementia (VaD) is the second most prevalent type of dementia characterized by progressive cognitive deficits and is a major risk factor for the development of Alzheimer's disease and other neurodegenerative disorders. This study is aimed at determining the potential neuroprotective effect of sitagliptin (STG) on cognitive deficits in L-methionine-induced VaD in rats and the possible underlying mechanisms. 30 adult male Wistar albino rats were divided equally (n = 10) into three groups: control, VaD, and VaD + STG groups. The cognitive performance of the animals was conducted by open field, elevated plus maze, Y-maze, novel object recognition, and Morris water maze tests. Serum homocysteine, TNF-α, IL-6, IL-10, total cholesterol, and triglycerides levels were assessed together with hippocampal MDA, SOD, and BDNF. Histopathological and immunohistochemical assessments of the thoracic aorta and hippocampus (CA1 region) were also performed. Chronic L-methionine administration impaired memory and learning and induced anxiety. On the other hand, STG protected against cognitive deficits through improving oxidative stress biomarkers, inflammatory mediators, lipid profiles, and hippocampus level of BDNF as well as decreasing caspase-3 and GFAP and increasing Ki-67 immunoreactions in the hippocampus. Also, STG improved the endothelial dysfunction via upregulation of aortic eNOS immunoreaction. STG improved the cognitive deficits of L-methionine-induced VaD by its antioxidant, anti-inflammatory, antiapoptotic, and neurotrophic effects. These findings suggest that STG may be a promising future agent for protection against VaD.
The moderating effect of big data analytics on green human resource management and organizational performance

ABSTRACT Green human resource management (GHRM) practices and big data analytics are becoming critical to enhance organizational performance. However, limited research has been conducted on GHRM practices and organizational performance in the presence of big data analytics. Therefore, this study aims to investigate the moderating effect of big data analytics on the relationship between GHRM practices and organizational performance. This explanatory study adopted a survey instrument to collect cross-sectional data from 189 respondents working in different organizations in Pakistan. The findings reveal a significant and positive effect of all GHRM practices on organizational performance. In addition, a substantial increase in the R2 models for all three dimensions of big data analytics as a moderator was found on the relationship between GHRM practices and organizational performance. This empirical study significantly enhances our understanding of how GHRM practices substantially influence organizational performance along with the use of big data analytics to maximize the benefits of GHRM and improve organizational efficiency. The study highlights the need to further explore green activities and behaviors for enhancing business value and competitive advantage. In addition, adoption of big data analytics supports faster decision-making, saves time and underpins efficient resource utilization to achieve operational and strategic efficiencies.
Incremental Value of Cardiac Biomarkers in Mid-term Prognosis of Patients with Acute Coronary Syndrome

Background: Given the number of prognostic studies, both short- and long-termed, in patients with myocardial infarction (MI), the data on predicting major adverse cardiac events (MACE) following discharge still remains limited. Aim: to identify early predictors of MACE in MI patients, that underwent Primary Percutaneous Coronary Intervention (pPCI), with special emphasis on multiple cardiac biomarkers. Materials and methods: we analysed clinical, LV functional, angiographic variables, as well cardiac troponin, a marker of myocardial necrosis, natriuretic peptide (NT-proBNP), a marker of myocardial stress, and white blood cells (WBC), as a marker of inflammation. The study population were 150 consecutive patients treated for acute myocardial infarction. Results: The average follow-up period was 31 months. In total, 26 patients suffered from at least one MACE. Multivariate logistic regression analysis identified several independent predictors: NT-proBNP (p=0,07), number of diseased vessels (p=0,027), and need for loop diuretic therapy (p=0,050). ROC curve demonstrated excellent discriminatory function for MACE of NT-proBNP and WBC (area under the curve .640, and .658, p=0.025 and 0.011 respectively). Conclusion: The combination of biomarkers for myocardial stress and inflammation improves the prediction of major adverse cardiac events in MI survivors. Keywords: myocardial infarction, cardiac biomarkers, cardiac troponin, natriuretic peptide, prognosis, major adverse cardiac events (MACE), cardiac death
Short-term radiographic outcome of varus osteotomy in the treatment of Legg-Calvé-Perthes disease: a retrospective case series study

Background: Varus osteotomy is a popular method for the operative treatment of Legg-Calvé-Perthes disease (LCPD). In this study, the authors aimed to evaluate the radiographic outcomes of varus osteotomy and its association with the extent of hip involvement. Methods: Twenty-one patients in early stages of disease (stage I and II of LCPD, according to the modified Elizabethtown classification) who were treated with varus osteotomy were studied. The radiographic outcome measures were Caput Index and epiphyseal quotient (EQ) that were assessed before the surgery and 2 yr postoperatively. The level of hip involvement was determined by the modified lateral pillar classification. Results: The mean Caput index of the patients improved from 55.5±12.7 to 74±13.4 (P<0.001). The mean EQ of the patients improved from 47.2±12.9% to 67.8±17.1% (P<0.001). According to the EQs, the radiographic outcomes were found to be good, fair, and poor in 16 (76.1%) patients, 4 (19.1%) patients, and 1 (4.8%) patient, respectively. The mean change of Caput Index and EQ was significantly more in the B/C lateral pillar group than C lateral pillar group (P=0.04 and P=0.02, respectively). Conclusions: Varus osteotomy could be recommended as an effective surgical treatment for LCPD. The level of hip involvement at presentation could be used as independent factors of surgical prognosis. Level of Evidence: Level III.