Miracle-dz/UniFAR-FTUs huggingface dataset:
Leachability and plant availability of trace elements in Pb/Zn mine soil treated with different amendments

A multi metal polluted soil from Jebel Ressas mining area (Southern of Tunisia) was treated with four cost-effective amendments (CaCO3, phosphate rock, activated carbon, and exhausted olive cake ash). Lixiviate from each treated and untreated soil were analyzed, and ryegrass-seed bioassays (Lolium perenne L.) were performed. The Cd, Pb and Zn leaching was reduced by all amendments mainly due to alkalinity increase. Phosphate rock addition to the soil reduced metal concentration in plant tissue. Additionally, the activated carbon amendment significantly decreased accumulation of Cd, Zn and Pb in the plant studied. The results obtained in this study suggest that the the addition of CaCO3 offered the best compromise as it successfully reduced both the leaching and the phytoavailability of the three considered metals.
Study of genetic control of salinity tolerance in bread wheat cv. Kavir-using generation mean analysis

Kavir wheat is one of the salinity tolerant cultivars that have been improved in Iran. In this research, F1, BC1, BC2 and F2 generations derived from a cross between Kavir × Arta and Kavir × Moghan3 (Arta and Moghan3 are susceptible to salinity) were evaluated through generation mean analysis in non-stress and salinity stress conditions in a randomized complete block design with three replications at the Agriculture Research Center of Kerman. The irrigation water salinity was 0.63 and 15 dS/m in non-stress and stress conditions, respectively. The salinity of farm soil was 2.1 dS/m in both conditions. The traits of flowering and maturity time, plant height, flag leaf relative water content, amount of Na+ and K+ in flag leaf, yield per plant and hundred seed weight were recorded for each treatment during the growth season and after harvest. The frequency distribution showed that Kavir was the superior parent in terms of the amount of Na+ while Arta and Moghan3 were the superior parent in terms of the amount of K+ and K+/Na+ in non-stress conditions. The concentration of Na+ decreased and the concentration of K+ and K+/Na+ increased in Kavir in stress conditions, while this condition was contrary in Arta and Moghan3. These results showed that when the plant encounters stress, some genes will be activated, which will result in a decrease in the concentration of Na+ and increase K+ uptake. Scale test results rejected the adequacy of the additive-dominance model and confirmed the presence of epistatic effects for these traits (except for K+/Na+ in stress conditions) in both environments. None of these tests were significant for the K+/Na+ in stress conditions. This result showed that the K+/Na+ was affected by additive × additive gene effect and the adequacy of the three-parametric models in the joint scaling test also confirmed this.
Tubularized incised plate urethroplasty and grafted tubularized incised plate urethroplasty: systematic review, meta-analysis and trial sequential analysis

Background Hypospadias is one of the most common genital birth defects. There are around 300 various techniques available for the repair of hypospadias. This study aims to compare the reported outcomes of Tubularized incised plate urethroplasty (TIP) and Grafted TIP (GTIP) repair in children undergoing primary hypospadias repair. Methods This meta-analysisadhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and we framed our research question using the population, intervention, control and outcomes format. We conducted comprehensive electronic searches across various databases, employing a Boolean search strategy with predefined search terms. Only randomized controlled trials (RCTs) were included for quantitative analysis. Results Totally, 10 RCTs met our inclusion criteria for quantitative analysis. The results indicated that urethrocutaneous fistula, glans dehiscence, and stricture rates were comparable between the two groups. The incidence of meatal stenosis was found to be significantly lower in the GTIP group with a relative risk (RR) of 0.32 (95% confidence interval (CI) 0.15 to 0.67). Conclusion The coucomes UCF, glans dehiscence, and stricture rates were comparable between the two groups. Notably, the incidence of meatal stenosis was found to be significantly lower in the grafted TIP group. In terms of operative time, our quantitative synthesis demonstrated that the TIP group had a shorter operative time than the GTIP group with significant heterogeneity.
Neuromodulation of Eating Disorders: A Review of Underlying Neural Network Activity and Neuromodulatory Treatments

Eating disorders are a group of psychiatric conditions that involve pathological relationships between patients and food. The most prolific of these disorders are anorexia nervosa, bulimia nervosa, and binge eating disorder. The current standard of care involves psychotherapy, pharmacotherapy, and the management of comorbid conditions, with nutritional rehabilitation reserved for severe cases of anorexia nervosa. Unfortunately, many patients often fail to respond, leaving a concerning treatment gap between the current and requisite treatments for eating disorders. To better understand the neurobiology underlying these eating disorders, investigations have been undertaken to characterize the activity of various neural networks, primarily those activated during tasks of executive inhibition, reward processing, and self-reference. Various neuromodulatory techniques have been proposed to stimulate these networks with the goal of improving patients’ BMI and mental health. The aim of this review is to compile a comprehensive summarization of the current literature regarding the underlying neural connectivity of anorexia nervosa, bulimia nervosa, and binge eating disorder as well as the numerous neuromodulatory modalities that have been investigated. Importantly, we aimed to summarize the most significant clinical trials to date as well as to provide an updated assessment of the role of deep brain stimulation, summarizing numerous recently published clinical studies that have greatly contributed to the literature. In this review, we found therapeutic evidence for transcranial magnetic stimulation and transcranial direct current stimulation in treating individuals suffering from anorexia nervosa, bulimia nervosa, and binge eating disorder. We also found significant evidence for the role of deep brain stimulation, particularly as an escalatory therapy option for the those who failed standard therapy. Finally, we hope to provide promising directions for future clinical investigations.
The integrated bioinformatic analysis identifies immune microenvironment-related potential biomarkers for patients with gestational diabetes mellitus

Background Gestational diabetes mellitus (GDM), a transient disease, may lead to short- or long-term adverse influences on maternal and fetal health. Therefore, its potential functions, mechanisms and related molecular biomarkers must be comprehended for the control, diagnosis and treatment of GDM. Methods The differentially expressed genes (DEGs) were identified using GSE49524 and GSE87295 associated with GDM from the Gene Expression Omnibus database, followed by function enrichment analysis, protein-protein interactions network construction, hub DEGs mining, diagnostic value evaluation and immune infiltration analysis. Finally, hub DEGs, the strongest related to immune infiltration, were screened as immune-related biomarkers. Results A hundred and seven DEGs were identified between patients with GDM and healthy individuals. Six hub genes with high diagnostic values, including ALDH1A1, BMP4, EFNB2, MME, PLAUR and SLIT2, were identified. Among these, two immune-related genes (PLAUR and SLIT2) with the highest absolute correlation coefficient were considered immune-related biomarkers in GDM. Conclusion Our study provides a comprehensive analysis of GDM, which would provide a foundation for the development of diagnosis and treatment of GDM.
D1-Like and D2-Like Dopamine Receptors in the Rat Prefrontal Cortex: Impacts of Genetic Generalized Epilepsies and Social Behavioral Deficits

The involvement of the prefrontal cortical dopaminergic system in the psychopathology of epilepsies and comorbid conditions such as autism spectrum disorder (ASD) still needs to be explored. We used autoradiography to study the D1-like (D1DR) and D2-like (D2DR) receptor binding density in the prefrontal cortex of normal Wistar rats and Wistar-derived strains with generalized convulsive and/or non-convulsive epilepsy. WAG/Rij rats served as a model for non-convulsive absence epilepsy, WAG/Rij-AGS as a model of mixed convulsive/non-convulsive form, and KM strain was a model for convulsive epilepsy comorbid with an ASD-like behavioral phenotype. The prefrontal cortex of rats with any epileptic pathology studied demonstrated profound decreases in binding densities to both D1DR and D2DR; the effects were localized in the primary and secondary anterior cingulate cortices, and adjacent regions. The local decreased D1DR and D2DR binding densities were independent of (not correlated with) each other. The particular group of epileptic rats with an ASD-like phenotype (KM strain) displayed changes in the lateral prefrontal cortex: D1DR were lowered, whereas D2DR were elevated, in the dysgranular insular cortex and adjacent regions. Thus, epilepsy-related changes in the dopaminergic system of the rat archeocortex were localized in the medial prefrontal regions, whereas ASD-related changes were seen in the lateral prefrontal aspects. The findings point to putative local dopaminergic dysfunctions, associated with generalized epilepsies and/or ASD.
Propofol with Varied Functions: A Potential Therapeutic Opportunity for Postoperative Nausea, Vomiting and Pruritus—A Narrative Review

Background: Despite the advances in anesthetics and non-pharmacological techniques, the prevalence of postoperative nausea and vomiting in all patients remains high. It is one of the most common distressing symptoms that cause dissatisfaction among patients after anesthesia and surgery. A sub-hypnotic dose of propofol has been shown to reduce morphine-induced postoperative nausea, vomiting, and pruritus. This review article will provide sufficient knowledge on the role of propofol in minimizing opioid-induced postoperative nausea, vomiting, and pruritus by providing detailed information on propofol antiemetic and antipruritic effects, as well as discussions based on empirically available data. Method: We conducted a narrative review of the literature published between 1990 and 2023 from a range of databases; PubMed, BioMed Central, Biosis Previews, Nature, International Pharmaceutical Abstracts, Springer-Link, and Elsevier
Facies architecture, detrital provenance, and tectonic modulation of sedimentation in the Shikoku Basin: Inputs to the Nankai Trough subduction zone

The Shikoku Basin is a back-arc basin located offshore southwest Japan. Sediments within the basin make up a key part of the subduction inputs to the Nankai Trough. A 19 m.y. history of sedimentation has been documented at Sites C0011 and C0012 of the Integrated Ocean Drilling Program (Kumano transect) and Sites 1173 and 1177 of the Ocean Drilling Program (Muroto and Ashizuri transects, respectively). This paper focuses on three noteworthy aspects of that history: (1) the onset of substantial pyroclastic influx, which shifted significantly along the strike length of the margin, from 3.3–3.9 Ma at Sites 1177 and 1173 to 7.6–7.8 Ma at Sites C0011 and C0012; (2) transport of sand by sediment gravity flows, which resulted in three discrete sand bodies during the Miocene (Kyushu, Daiichi Zenisu, and Daini Zenisu submarine fans); and (3) clay mineral assemblages within hemipelagic mudstones, which show systematic reduction of 3 wt% detrital smectite per 1 m.y. decrease in age. Collectively, these temporal and spatial adjustments of lithofacies and sediment composition have important implications for downdip and along-strike projections of frictional, geotechnical, and hydrogeological properties as strata enter the Nankai subduction zone. The stratigraphic positions of smectite-rich Miocene mudstones, for example, should match up with increases in the volume of fluid production by clay dehydration during subduction. The higher-permeability sand bodies (Kyushu and Zenisu submarine fans) should act as preferred conduits for focused fluid flow. The potential for buildup of fluid overpressures should increase above and laterally adjacent to stratigraphic pinch-outs of sand bodies, especially where the aquifers are inclined or confined between basement highs. These three-dimensional complexities set the Nankai-Shikoku system apart from other subduction zones (e.g., Japan Trench, Costa Rica) where inputs consist of comparatively homogeneous pelagic and hemipelagic deposits.
Multi environmental evaluation for selection of stable and high yielding sugarcane (Saccharum officinarum L.) clones based on AMMI and GGE biplot models

The present study was aimed to evaluate the G x E (genotype x environment) interaction using AMMI and GGE biplot analysis to identify sugarcane (Saccharum officinarum L.) genotypes that combine high yield and stability in multi-location trials. Twelve advanced clones generated in the sugarcane breeding programs along with three standards (Co 86032, CoC 671 and Co 09004) were evaluated for cane and sugar yield using randomized complete block design with three replicates over two plant crops and one ratoon during 2019 to 2021 across two years and locations. Data was collected on yield traits and sugar quality characters. Stability parameters were determined. The data was also investigated using GGE biplot and the AMMI models. The results of combined analyses of variance exhibited significant differences among genotypes at the three test environments and when locations were combined. The GE interaction was also significant for all the traits, indicating inconsistency of performance of the genotypes over the locations and seasons. Pooled data analysis of 15 genotypes indicated the superiority of Co 15017 and CoN 15071 for CCS yield across six environments. Two clones, Co 15017 and CoSnk 15102 recorded higher mean cane yield as compared with three standards across the six experimental conditions. Multivariate (AMMI and GGE biplot) statistical analysis indicated that CoSnk 15102 exhibited higher and more stable commercial cane sugar yield and cane yield per hectare, indicating this genotype’s suitability across the test locations. The results of such multi-environmental trials with the elucidation of GE interaction using AMMI and GGE are of great significance in guiding the selection and recommendation of stable and superior varieties in sugarcane production zones.
Escitalopram treatment ameliorates chronic immobilization stress-induced depressive behavior and cognitive deficits by modulating BDNF expression in the hippocampus

Major depressive disorder (MDD) affects 21% of the global population. Chronic exposure to stressful situations may affect the onset, progression, and biochemical alterations underlying MDD and associated cognitive impairments. Patients exhibiting MDD are mainly treated with several antidepressants; one is escitalopram, a selective serotonin reuptake inhibitor. However, whether or not it mitigates chronic stress-induced cognitive deficits is unknown. The present study exposed rats to chronic immobilization stress (CIS) 2 hours/day for 10 days. Then, escitalopram (5 mg and 10 mg/kg i.p.) was administered for 14 days and subjected to the elevated plus maze, open field test, forced swim test, sucrose preference test, and radial arm maze task. A different set of animals were used to assess the vascular endothelial growth factor (VEGF), glial fibrillary acidic protein (GFAP), and brain derived neurotrophic factor (BDNF) levels in the hippocampus, frontal cortex, and amygdale. Our data suggest that escitalopram significantly protected CIS-induced spatial learning and memory deficits, behavioral depression, and anxiety. Furthermore, escitalopram (10 mg/kg) shows a remarkable recovery of dentate gyrus and hippocampal atrophy. In addition, the restoration of molecular markers BDNF, VEGF, and GFAP expression is also implicated in the neuroprotective mechanisms of escitalopram. Our results suggested that esciatlorpam restores cognitive impairments in stressed rats by regulating neurotrophic factors and astrocytic markers.
Could MMP3 and MMP9 Serve as Biomarkers in EBV-Related Oropharyngeal Cancer

The high incidence of, and mortality from, head and neck cancers (HNCs), including those related to Epstein–Barr virus (EBV), constitute a major challenge for modern medicine, both in terms of diagnosis and treatment. Therefore, many researchers have made efforts to identify diagnostic and prognostic factors. The aim of this study was to evaluate the diagnostic usefulness of matrix metalloproteinase 3 (MMP 3) and matrix metalloproteinase 9 (MMP 9) in EBV positive oropharyngeal squamous cell carcinoma (OPSCC) patients. For this purpose, the level of these MMPs in the serum of patients with EBV-positive OPSCC was analyzed in relation to the degree of histological differentiation and TNM classification. Our research team’s results indicate that the level of both MMPs is much higher in the EBV positive OPSCC patients compared to the EBV negative and control groups. Moreover, their levels were higher in more advanced clinical stages. Considering the possible correlation between the level of MMP 3, MMP 9 and anti-EBV antibodies, and also viral load, after statistical analysis using multiple linear regression, their high correlation was demonstrated. The obtained results confirm the diagnostic accuracy for MMP 3 and MMP 9. Both MMPs may be useful in the diagnosis of EBV positive OPSCC patients.
Forecasting the Eruption of an Open‐Vent Volcano Using Resonant Infrasound Tones

Open‐vent volcanic systems with active degassing are particularly effective at producing infrasound that exhibits resonant tones controlled by the geometry of the volcano's crater. Changes in the infrasound character can thus provide constraints on a crater's lava level, which may vary dynamically in the lead‐up to an eruption. Here we show that the increasing frequency content and damping characteristics of the resonant infrasound at Volcán Villarrica (Chile) relate to lava lake position in its crater/conduit preceding its 2015 eruption. We model the acoustic response of Villarrica's crater to determine that the lake began to rise on 27 February and reached the flared upper part of Villarrica's crater before oscillating during the two days prior to the 3 March paroxysm and 1.5 km‐high lava fountain. This study demonstrates the utility of remote infrasound monitoring for future eruptions of Villarrica and other analogous open‐vent volcanoes.
Detecting Psychological Interventions Using Bilateral Electromyographic Wearable Sensors

This study investigated the impact of auditory stimuli on muscular activation patterns using wearable surface electromyography (EMG) sensors. Employing four key muscles (Sternocleidomastoid Muscle (SCM), Cervical Erector Muscle (CEM), Quadricep Muscles (QMs), and Tibialis Muscle (TM)) and time domain features, we differentiated the effects of four interventions: silence, music, positive reinforcement, and negative reinforcement. The results demonstrated distinct muscle responses to the interventions, with the SCM and CEM being the most sensitive to changes and the TM being the most active and stimulus dependent. Post hoc analyses revealed significant intervention-specific activations in the CEM and TM for specific time points and intervention pairs, suggesting dynamic modulation and time-dependent integration. Multi-feature analysis identified both statistical and Hjorth features as potent discriminators, reflecting diverse adaptations in muscle recruitment, activation intensity, control, and signal dynamics. These features hold promise as potential biomarkers for monitoring muscle function in various clinical and research applications. Finally, muscle-specific Random Forest classification achieved the highest accuracy and Area Under the ROC Curve for the TM, indicating its potential for differentiating interventions with high precision. This study paves the way for personalized neuroadaptive interventions in rehabilitation, sports science, ergonomics, and healthcare by exploiting the diverse and dynamic landscape of muscle responses to auditory stimuli.
Reconciling Drivers of Seasonal Terminus Advance and Retreat at 13 Central West Greenland Tidewater Glaciers

The majority of Greenland tidewater glaciers undergo a seasonal cycle in terminus position, characterized by wintertime advance and summertime retreat. Understanding mechanisms that control seasonal cycles can help elucidate how tidewater glaciers regulate dynamic ice loss on longer timescales. However, controls on terminus position are numerous and complex. To address this, we compare time series of satellite‐derived terminus positions for tidewater glaciers in central west Greenland with observations of environmental forcings, including runoff at the grounding line, mélange presence, and, where available, ocean temperature in the proglacial fjord. We show that for most glaciers, seasonal terminus positions are more sensitive to glacial runoff than mélange or ocean thermal forcing. The strength of this relationship differs for two end‐member glacier types in the region, defined by their terminus geometry and dominant calving style. First, we find a strong relationship between magnitudes of runoff and terminus retreat at tidewater glaciers with shallow grounding lines (<400 m) that calve primarily through small‐magnitude serac failures. At these glaciers, subglacial plumes drive submarine melt and locally enhance retreat, causing heterogeneous position change across the terminus and local embayments where seasonal terminus changes are largest. In contrast, deep termini susceptible to buoyant flexure retreat sporadically through full ice thickness calving events less dependent on runoff. While less common, these glaciers deliver larger ice fluxes to the ocean. With predicted surface melt increases and diminished mélange coverage in a warming climate, our results reveal the impact of environmental forcings on diverse tidewater glacier systems in the region.