Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgery and Prophylaxis with Susoctocog-Alfa in Acquired Hemophilia: Case Series and Literature Review

Background: Acquired hemophilia A (AHA) is a rare bleeding disease due to autoantibodies directed against clotting factor VIII (FVIII). Treatment of AHA consists of inhibitor eradication with immunosuppressive therapy (IST) and prompt control of bleeding obtained with bypassing agents or recombinant porcine FVIII (rpFVIII). The latter has recently been licensed for management of acute bleeding in AHA. Unlike treatment with bypassing agents, rpFVIII can be monitored to provide a successful hemostatic effect and avoid overtreatment. Correlation between rpFVIII inhibitor titers and efficacy of rpFVIII treatment remains a matter of debate. Methods: We report three cases of AHA in which rpFVIII was successfully used with an unconventional schedule despite the presence of medium–high titers of the rpFVIII. The modified Nijmegen–Bethesda inhibitor assay (NBA) was used to dose porcine FVIII inhibitors. Result: The presence of rpFVIII inhibitors prior to the exposition to susoctocog-alfa, that may suggest a cross-reactivity with human FVIII inhibitors, did not affect hemostasis. Conclusion: In our experience, rpFVIII demonstrates safety and efficacy in the presence of rpFVIII inhibitors and using an unconventional schedule in both the perioperative and outpatient settings. Laboratory measurement of inhibitors against rpFVIII during treatment is described for the first time.
Short‐term responses of soil organic carbon and chemical composition of particle‐associated organic carbon to anaerobic soil disinfestation in degraded greenhouse soils

Anaerobic soil disinfestation (ASD) is a short‐term practice to conquer soil degradation, yet its effects on soil organic carbon (SOC) and its composition remain unclear. A field experiment was conducted in degraded greenhouse soils (C3) that were previously used for production of vegetable (VP) and flower (FP), with three treatments (i.e., control, ST [maize straw addition [C4]] and ASD [both ST and water flooding]) for 21 days. Results indicated that the control soil lost 1.3 Mg C ha−1 in VP and 0.94 Mg C ha−1 in FP, while ST increased SOC storage by over 1.0 Mg C ha−1 in both VP and FP. The ASD increased SOC storage by over 2.0 Mg C ha−1 by forming new SOC and decreasing old SOC loss. Additionally, ASD increased OC concentration in particulate size fractions, particularly in particulate organic matter (POM) with lower basal respiration, and higher hydrophobicity as indicated by an increased ratio of C–H/C=O from POM observed by FTIR. The SEM‐EDS found an enhanced C signal in particle size fractions, especially in POM. Overlap of C, O, Si, Ca, and Fe in mineral‐associated organic matter upon ASD indicated the possible crosslinking between intra‐OC and minerals containing O, Si, Ca, and Fe. The ASD also controlled soil salinization and the pathogen Fusarium oxysporum, resulting in increased tomato yields in both VP and FP. Overall, apart from increasing tomato yields, ASD can enhance SOC storage by increasing OC in particle size fractions within a short term.
Classifying BCI signals from novice users with extreme learning machine

Abstract Brain computer interface (BCI) allows to control external devices only with the electrical activity of the brain. In order to improve the system, several approaches have been proposed. However it is usual to test algorithms with standard BCI signals from experts users or from repositories available on Internet. In this work, extreme learning machine (ELM) has been tested with signals from 5 novel users to compare with standard classification algorithms. Experimental results show that ELM is a suitable method to classify electroencephalogram signals from novice users.
Can online travel agencies contribute to the recovery of the tourism activity after a health crisis?

PurposeOnline travel agencies (OTAs) have an important role to play in reactivating tourism activity following a health crisis by providing information about the health conditions of tourist destinations. Once developed, it is necessary to analyze the effectiveness of the information provided and ascertain whether the provision of such information effects the understanding of the value of using OTAs and, in turn, the intention to do so.Design/methodology/approachThis paper, based on an empirical case study conducted during the COVID-19 pandemic, examines whether following a health crisis, the quality of information provided by OTAs on the health conditions of tourist destinations and the perceived value of their offer generate a greater OTA services reuse intention, and signals, therefore, a return to travel.FindingsThe results show the quality of the information positively influences the perceived value, but not the OTA services reuse intention. Rather, the perceived value positively influences the OTA services reuse intention.Practical implicationsOverall, it can be suggested that providing quality health information for a destination is a necessary strategy because it contributes to increasing the perceived value of OTAs. To incentivize the intention for repeated use of OTA services, it is necessary to consider the perceived value that influences the intention to make repeat OTA reservations.Originality/valueThis research offers a novel perspective about the OTAs’ contribution to the recovery of the activity of the tourism industry after a health crisis. This contributes to achieving a more resilient sector in the face of future health crises.
Integrator-based robust H ∞ sliding mode control of uncertain stochastic Markovian jump delay systems with non-linear perturbations

This study is concerned with the problem of robust H ∞ sliding mode control (SMC) of It o ^ stochastic delayed Markovian jump systems subject to parameter uncertainties and non-linear perturbations. Firstly, for the sake of practicality, a common integral sliding surface functional without time-varying delay is proposed. Then, by using linear matrix inequalities technique, sufficient condition for the robust mean-square exponential stability of the resulting closed-loop system with a prescribed disturbance attenuation level γ is derived. Moreover, a novel sliding mode controller is designed such that system trajectories can be kept on the sliding surface almost surely since the initial time. Finally, an example is provided to illustrate the effectiveness of the obtained result.
Spatial–Spectral 1DSwin Transformer With Groupwise Feature Tokenization for Hyperspectral Image Classification

The hyperspectral image (HSI) classification aims to assign each pixel to a land-cover category. It is receiving increasing attention from both industry and academia. The main challenge lies in capturing reliable and informative spatial and spectral dependencies concealed in the HSI for each class. To address the challenge, we propose a spatial–spectral 1DSwin (SS1DSwin) Transformer with groupwise feature tokenization for HSI classification. Specifically, we reveal local and hierarchical spatial–spectral relationships from two different perspectives. It mainly consists of a groupwise feature tokenization module (GFTM) and a 1DSwin Transformer with cross-block normalized connection module (TCNCM). For GFTM, we reorganize an image patch into overlapping cubes and further generate groupwise token embeddings with multihead self-attention (MSA) to learn the local spatial–spectral relationship along the spatial dimension. For TCNCM, we adopt the shifted windowing strategy when acquiring the hierarchical spatial–spectral relationship along the spectral dimension with 1-D window-based MSA (1DW-MSA) and 1-D shifted window-based MSA (1DSW-MSA) and leverage cross-block normalized connection (CNC) to adaptively fuse the feature maps from different blocks. In SS1DSwin, we apply these two modules in order and predict the class label for each pixel. To test the effectiveness of the proposed method, extensive experiments are conducted on four HSI datasets, and the results indicate that SS1DSwin outperforms several current state-of-the-art methods. The source code of the proposed method is available at https://github.com/Minato252/SS1DSwin.
ESTIMATING THE CARDINALITY OF A DIFFERENCE SUBSET OF THE DISCRETE MULTI-TORUS Z n

In this paper, we obtain an upper estimate for the cardinality of a subset of the discrete torus over a field of three elements of which any four points do not form a nonsingular parallelogram. Let a1 and a2 be arbitrary elements of Z n . The difference a1 − a2 is called a direction. We observe that two differences a1 − a2 and a3 − a4 generate the same direction if a1 − a2 ≡ a3 − a4 (mod 3), where a1 ,a 2 ,a 3 ,a 4 ∈ Z n . A direction a2 − a1 is the opposite direction for a1 − a2. Lemma 1. Any four distinct points of Z n , lying in pairs on two parallel lines, form a nondegenerate parallelogram. ∗ Deceased.
Weight increase in people with cystic fibrosis on CFTR modulator therapy is mainly due to increase in fat mass

Background: Ivacaftor, the first CFTR modulator drug, leads to significant long-term improvement in lung function and weight gain. The mechanism as well as the long-term impact of ivacaftor on weight, resting energy expenditure (REE) and body composition remains to be explored. Methods: This prospective observational study included 18 people with CF (pwCF) (age: median (range) 20 (6–58) years) carrying at least one CFTR gating mutation commencing ivacaftor. Assessments of body composition, REE and laboratory investigations were performed at baseline and 6, 12 and 24 months after treatment initiation. Results: Treatment with ivacaftor was associated with a significantly positive change in BMI z-score at 24 months. Fat mass (mean (95% CL) of 6.5 kg (4.0; 9.0) from baseline, p = 0.0001), but not fat-free mass changed under ivacaftor treatment. There was a significant positive correlation between weight and fat mass change. Overall, there was no significant change in measured REE from baseline (mean (95% CL) of 108 kcal/d (−12; 228), p = 0.07) in our cohort. Pancreatic function and other nutritional markers did not change with treatment, with the exception of an increase in serum vitamin A levels (p = 0.006). Conclusion: The weight gain observed in ivacaftor treated pwCF is predominantly secondary to increases in fat mass warranting early counseling of people starting on CFTR-modulating treatment with respect to healthy diet and physical exercise.
Stereotyped, repetitive gunshot call patterns produced by the North Pacific right whale, Eubalaena japonica

The Marine Mammal Laboratory has deployed long-term passive acoustic recorders along the 50 m and 70 m isobaths throughout the Bering Sea since 2007. Instruments recorded at either 4 kHz on a ~7-11% duty cycle, or 8 kHz on a 30-45% duty cycle. In addition, directional sonobuoys were deployed during field surveys to allow real-time monitoring for large whale presence. During the 2010 survey, a stereotyped, repetitive gunshot call pattern was acoustically detected on sonobuoys. This same call pattern was then detected on two different long-term moored recorders in two separate years. Since then, six different stereotyped, repetitive patterns have been documented, three of which have been analyzed. Preliminary results show that each pattern has a minimum of 30 iterations repeated over several hours. Furthermore, in several cases, these patterns are repeated throughout the season, in consecutive years, and in one instance, in non-consecutive years. While male North Atlantic right whales produce long gunshot b.
Analysis Of The Effects Of Attitude, Subjective Norms, and Perceived Behavioral Control On Consumer Purchase Intention Of Natural Gas For Vehicle With The Moderating Role Of Price Sensitivity

This research aims to determine consumers purchase intention in using natural gas for vehicle with the moderating role of price sensitivity. This study used a quantitative approach in the form of a survey method. The population in this study consists of car users with fuel-powered vehicles located in the JABODETABEK area who have never owned a natural gas for vehicle before. The sample in this study consists of 122 car users with fuel-powered vehicles. Data processing is performed using the Partial Least Square (PLS) method. The results of this study indicate that attitude, perceived behavioural control, and price sensitivity have a significant influence on consumer purchase intention, while subjective norms do not have a significant influence. Price sensitivity also affects the relationship between subjective norms but does not affect the relationship between attitude and perceived behavioural control with consumer purchase intention. This study explores the impact of behaviour on purchase intention, emphasizing the management perspective. It reveals that positive attitudes towards environmentally friendly gas as an alternative fuel can be enhanced. The findings suggest that exogenous constructs moderately affect consumer purchase intention. Further research is needed to strengthen the influence of the dependent variable using additional variables.
Lifetime prediction under dead-load long-term creep test and models analysis of wood-plastic composites for building materials

ABSTRACT Optimal formulation of wood-plastic composites (WPCs) from recycled polypropylene (rPP) and rubberwood flour (RWF) was determined. Mechanical properties and long-term creep behaviour of rPP and WPCs were investigated. This study revealed that an increasing of rubberwood flour content clearly increases the flexural, compressive, and tensile values. The modulus of composite samples linearly increased with an increasing amount of RWF. The creep behaviour test with load levels at 20, 30, and 40% of the ultimate flexural strength were conducted for 1000 h. The deflection of the composites at the same load levels of rPP gave the higher creep behaviour (2.45, 4.65, and 6.68 mm) than that of WPCs (1.53, 2.41, and 3.37 mm), respectively. Six-element for determining Burger model parameters was well fitted with the long-term creep of WPCs, this deflection result was compared to four-element Burger and Power law models. Finally, the master curve could predict lifetime of composite materials.
Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs–An exploratory study

Closed-head traumatic brain injury (TBI) is induced by rapid motion of the head, resulting in diffuse strain fields throughout the brain. The injury mechanism(s), loading thresholds, and neuroanatomical distribution of affected cells remain poorly understood, especially in the gyrencephalic brain. We utilized a porcine model to explore the relationships between rapid head rotational acceleration-deceleration loading and immediate alterations in plasmalemmal permeability within cerebral cortex, sub-cortical white matter, and hippocampus. To assess plasmalemmal compromise, Lucifer yellow (LY), a small cell-impermeant dye, was delivered intraventricularly and diffused throughout the parenchyma prior to injury in animals euthanized at 15-min post-injury; other animals (not receiving LY) were survived to 8-h or 7-days. Plasmalemmal permeability preferentially occurred in neuronal somata and dendrites, but rarely in white matter axons. The burden of LY+ neurons increased based on head rotational kinematics, specifically maximum angular velocity, and was exacerbated by repeated TBI. In the cortex, LY+ cells were prominent in both the medial and lateral gyri. Neuronal membrane permeability was observed within the hippocampus and entorhinal cortex, including morphological changes such as beading in dendrites. These changes correlated with reduced fiber volleys and synaptic current alterations at later timepoints in the hippocampus. Further histological observations found decreased NeuN immunoreactivity, increased mitochondrial fission, and caspase pathway activation in both LY+ and LY– cells, suggesting the presence of multiple injury phenotypes. This exploratory study suggests relationships between plasmalemmal disruptions in neuronal somata and dendrites within cortical and hippocampal gray matter as a primary response in closed-head rotational TBI and sets the stage for future, traditional hypothesis-testing experiments.
Solution of Linear Elastostatic and Elastodynamic Plane Problems by the Meshless Local Petrov-Galerkin Method

This chapter very briefly reviews the literature on meshless methods. The Meshless Local Petrov-Galerkin (MLPG) method is adopted to solve plane strain/stress solid mechanics problems. The MLPG formulation including the moving least squares method, the choice of the weight function, the local symmetric weak form (LSWF), and the discretization of the weak form are presented. A code based on the MLPG method is developed, and three numerical examples, namely, a cantilever beam loaded by tangential tractions at the unclamped edge, an infinite plate with a circular hole subjected to a uniform tensile force at infinity, and a hollow circular cylinder subjected to a pressure on the inner surface are demonstrated to validate the developed code.
The Influence of Gifted and Talented Programs on Students’ Self-concept

The purpose of this research is to explore the influence of high school gifted and talented (GT) programs on students’ self-concept from the students’ perspectives in the UAE. A qualitative, exploratory, interview-based study was employed to answer the following question: How gifted and talented programs influence students’ self-concept? Data were collected using semi-structured interviews. Ten GT students from grades 8-12 were interviewed from three different GT programs in UAE schools. Analysis revealed that students exhibited positive self-concept in three dimensions: general, academic, and social. The GT programs in the UAE seem to influence students’ self-concept positively by nurturing their strengths, valuing their efforts, developing their skills, and emphasizing their future roles in the community. Keywords: self-concept, BFLPE, acceleration, enrichment, gifted and talented
The Temporal Variation of Secondary Metabolites in the Mycobiont Culture and Thallus of Parmelina carporrhizans and Parmelina quercina Analyzed using High-Performance Liquid Chromatography

Lichens are composite organisms that produce a wide variety of secondary metabolites; many of the compounds have a high potential as bioactive compounds. The major limitations of using bioactive compounds from lichens is their slow growth rate and the damage to environmental populations caused by massive collection. The alternative to the massive collection of lichens in the field is their culture under laboratory conditions. We chose two related lichen species of Parmeliaceae that produce similar metabolites and isolated from spores in cultures placed under axenic conditions for over 550 days. From these cultures, we sampled 35 mg of each species from different culture media at two sampling times. The samples were analyzed using high-performance liquid chromatography (HPLC) to detect and identify major compounds. We found no differences in the metabolites produced within the species in comparisons between different culture media. Our results show that the mycobiont cultures produced different secondary metabolites than those found in natural lichen thalli. Moreover, different secondary metabolites between species and different metabolites over time were observed. We conclude that mycobiont cultures are a promising alternative for determining bioactive compounds and enhancing the efficiency of growth and production. These could be a good option for eco-friendly metabolite production.
Inhibition of Autophagy and the Cytoprotective Role of Smac Mimetic against ROS-Induced Cancer: A Potential Therapeutic Strategy in Relapse and Chemoresistance Cases in Breast Cancer

With more than a million deaths each year, breast cancer is the top cause of death in women. Around 70% of breast cancers are hormonally responsive. Although several therapeutic options exist, cancer resistance and recurrence render them inefficient and insufficient. The major key reason behind this is the failure in the regulation of the cell death mechanism. In addition, ROS was also found to play a major role in this problem. The therapeutic benefits of Smac mimetic compound (SMC) BV6 on MCF7 were examined in the current study. Treatment with BV6 reduces viability and induces apoptosis in MCF7 breast cancer cells. BV6 suppresses autophagy and has demonstrated a defensive role in cancer cells against oxidative stress caused by H2O2. Overall, the present investigation shows that SMC has therapeutic and cytoprotective potential against oxidative stress in cancer cells. These Smac mimetic compounds may be used as anti-cancer drugs as well as antioxidants alone or in conjunction with other commonly used antioxidants.
Inlet Flow Separation Control via Novel Lip-Spoilers for Ducted Fan Based VTOL Uninhabited Aerial Vehicles

The ducted fan propulsion systems provide attractive solutions for manned and unmanned aerial vehicles, with potential applications in general aviation and military missions. They provide higher power-to-thrust ratios over their free-rotor counterpart. However, ducted fans currently implemented in vertical takeoff and landing (VTOL) type aerial vehicles have an inherent duct lip separation and inlet flow distortion problem in edgewise flight. This problem is severe when the flight direction of the VTOL vehicle and the rotor axis of rotation are normal to each other. Separation at the leading edge duct lip for this high angle of attack situation disallows flow from effectively entering the fan rotor causing unwanted inlet flow distortion. Discussed here will be optimized design solutions to controlling and/or eliminating this flow separation at the leading edge duct lip. The designed were three types of lip-s: parametric, detached duct lip, and double duct. The parametric lip-spoilers consisted of inner-face and outer-face duct lip-spoilers. Inner-face duct lip-spoilers predominantly contributed to increased control over the negative nose-up pitching moment while the outer face and detached duct lip-spoilers predominantly controlled the increase in the mass flow rate through the ducted fan rotor. The double-ducted fan (DDF) was successful in eliminating duct lip separation through its added second duct. The main purpose of this study is to design and test various duct lip-spoilers that improves the ducted fan aerodynamic performance in edgewise flight. The conceptual design, analysis and flow visualization for a number of novel lip-spoilers are discussed in detail.
A Comparative Evaluation of Efficacy of Various Obturating Techniques for the Presence of Voids

Aim: Evaluation of the efficacy of different obturating techniques and assessment of the presence of voids in different regions of the canal. Materials and Methods: Sixty permanent single-rooted teeth with complete, mature root apices without any anatomic variation having straight patent root canals were included in the present study. Access cavity preparation followed by biomechanical preparation was done. Samples were divided into three groups—Group A: Single cone obturation, Group B: GuttaFlow 2, and Group C: GuttaCore, and obturation was carried out. The samples after obturation were stored at 370°C and 100% humidity in an incubator for 7 days to give adequate time for obturating materials to set. Cone beam computed tomography was performed with i-cat Cb 500 machine. The voids were checked on the root canal wall. The statistical analysis was done and the data after the statistical analysis was presented. Result: GuttaCore obturators presented a lesser volume of voids followed by GuttaFlow 2 than the single cone techniques. Conclusion: All the obturation techniques presented an inadequacy of obturation when the pre- and post-obturated volume of the root canal space was calculated. However, no statistically significant obturated volume differences were found between single cone and GuttaFlow 2 or between GuttaFlow 2 and GuttaCore system.