Miracle-dz/UniFAR-FTUs huggingface dataset:
“New normal” at work in a post-COVID world: work–life balance and labor markets

The coronavirus pandemic has interrupted labor markets, triggering massive and instant series of experimentations with flexible work arrangements, and new relationships to centralized working environments. These approaches have laid the basis for the “new normal,” likely extending into the organization of work in the post-pandemic era. These new arrangements, especially flexible work arrangements, have challenged traditional relationships with employees and employers, work time and working hours, the work–life balance (WLB), and the relationship of individuals to work. This paper investigates how labor markets have been interrupted due to the pandemic, focusing especially on manual (blue-collar) and nonmanual (white-collar) work and the future of the WLB, along with exploring the projected deviations that are driving a foreseeable future policy revolution in work and employment. This paper argues that although hybrid and remote working would be more popular in the post-pandemic for nonmanual work, it will not be “one size fits all” solution. Traditional work practices will remain, and offices will not completely disappear. Manual labor will continue current work practices with increased demands. Employers’ attention to employees’ WLB in the new normal will target employees’ motivation and achieving better WLB. These trends for the labor market and WLB are classified into three categories—those that are predicated on changes that were already underway but were accelerated with arrival of the pandemic (“acceleration”); those that represent normalization of what were once considered avant-garde ways of work (“normalization”); and those that represent modification or alteration of pre-pandemic set-up (“remodelling”).
Alcohol metabolism genes and risks of site‐specific cancers in Chinese adults: An 11‐year prospective study

Two genetic variants that alter alcohol metabolism, ALDH2‐rs671 and ADH1B‐rs1229984, can modify oesophageal cancer risk associated with alcohol consumption in East Asians, but their associations with other cancers remain uncertain. ALDH2‐rs671 G>A and ADH1B‐rs1229984 G>A were genotyped in 150 722 adults, enrolled from 10 areas in China during 2004 to 2008. After 11 years' follow‐up, 9339 individuals developed cancer. Cox regression was used to estimate hazard ratios (HRs) for site‐specific cancers associated with these genotypes, and their potential interactions with alcohol consumption. Overall, the A‐allele frequency was 0.21 for ALDH2‐rs671 and 0.69 for ADH1B‐rs1229984, with A‐alleles strongly associated with lower alcohol consumption. Among men, ALDH2‐rs671 AA genotype was associated with HR of 0.69 (95% confidence interval: 0.53‐0.90) for IARC alcohol‐related cancers (n = 1900), compared to GG genotype. For ADH1B‐rs1229984, the HRs of AG and AA vs GG genotype were 0.80 (0.69‐0.93) and 0.75 (0.64‐0.87) for IARC alcohol‐related cancers, 0.61 (0.39‐0.96) and 0.61 (0.39‐0.94) for head and neck cancer (n = 196) and 0.68 (0.53‐0.88) and 0.60 (0.46‐0.78) for oesophageal cancer (n = 546). There were no significant associations of these genotypes with risks of liver (n = 651), colorectal (n = 556), stomach (n = 725) or lung (n = 1135) cancers. Among male drinkers, the risks associated with higher alcohol consumption were greater among ALDH2‐rs671 AG than GG carriers for head and neck, oesophageal and lung cancers (Pinteraction < .02). Among women, only 2% drank alcohol regularly, with no comparable associations observed between genotype and cancer. These findings support the causal effects of alcohol consumption on upper aerodigestive tract cancers, with ALDH2‐rs671 AG genotype further exacerbating the risks.
Test of Fabric Anti-static Properties

Aiming at the electrostatic phenomena of fabric,the factors including temperature,humidity,friction conditions,resistivity and other factors that affect the antistatic properties of fabric were analysed and their different test results under different conditions were also analysed.It used constant pressure and timing method to carry out static test for 15 type of material.The results showed that the fabric thickness,material composition,and finishing process on the static nature of the fabric had a significant effect,and the two kinds of test methods had their own adaptation of the test object.
Giant cell arteritis with simultaneous onset of multiple intracranial vascular occlusions: A case report

Background: Giant cell arteritis (GCA) causes severe stenosis or occlusion of the arteries but rarely affects the intracranial arteries. We report a rare case of GCA along with autopsy results. Case Description: A 69-year-old man developed gait disturbance due to vertebral artery (VA) occlusion. As is common in atherothrombotic stroke, dual antiplatelet therapy was administered. The patient’s symptoms improved temporarily. However, his symptoms relapsed and his consciousness was acutely disturbed. Digital subtraction angiography revealed an appearance of stenosis of the internal carotid artery (ICA) C2 portion on the right side and decreased retrograde basilar artery (BA) blood flow through the right posterior communicating artery. Balloon angioplasty was performed, and BA blood flow increased. GCA was suspected, and a definitive diagnosis was made based on temporal artery biopsy findings. Steroid therapy was initiated but failed to control disease progression, and the patient died. The autopsy findings revealed GCA in the bilateral ICAs and VAs, and no signs of GCA were found in other intracranial arteries, despite occlusion on magnetic resonance angiography. Conclusion: GCA of the intracranial blood vessels is rare and might be more likely to occur in the ICAs and VAs than in other intracranial blood vessels. GCA of the intracranial blood vessels has a poor prognosis, and as such, if rapid changes are observed in the ICAs or VAs, GCA should be considered a part of the differential diagnosis and immediate treatment should be administered.
INCIDENCE AND ETIOLOGY OF RESPRATORY DISTRESS IN LOW BIRTH WEIGHT NEONATES BORN IN RURAL TERTIARY CARE CENTRE.

Background : To Study The Incidence And Etiology Of Respratory Distress In Low Birth Weight Neonates Born In Rural Tertiary Care Centre. Methods: This is a prospective observational study. It was carried out in neonatal division of department Of pediatrics MMIMSR, Mullana. The study included 200 low birth weight neonates born during the study period. Results: Out of 200 neonates 63 had respiratory distress. The incidence of respiratory distress in index study was 31.5%. According to weight distribution the incidence of respiratory distress among neonates with 1.5kg to 2.499kg was 27.6% , 1kg to <1.5kg was 57.1% and <1kg was 100%. According to gestation the incidence of respiratory distress among term was 29.8% and preterm was 33.6%. The most common cause of respiratory distress was transient tachypnea of newborn(33.8%) followed by hyaline membrane disease(24.1%), sepsis(17.7%), apnea(9.6%), CVS disorder(6.4%). Conclusion: Low birth weight and preterm deliveries are at higher risk for morbidity during and after the birth. Early antenatal care will greatly reduce the incidence of respiratory distress syndrome in neonates. The incidence increases as birth weight and gestation decreases in neonates Due to recent medical advances and skilled clinical practice the incidence of RDS has decreased. Transient tachypnea of newborn remains the main etiology of respiratory distress in neonates.
Stage‐specific differential expression of zinc transporter SLC30A and SLC39A family proteins during prostate tumorigenesis

Prostate cancer (PCa) initiation and progression uniquely modify the prostate milieu to aid unrestrained cell proliferation. One salient modification is the loss of the ability of prostate epithelial cells to accumulate high concentrations of zinc; however, molecular alterations associated with loss of zinc accumulating capability in malignant prostate cells remain poorly understood. Herein, we assessed the stage‐specific expression of zinc transporters (ZNTs) belonging to the ZNT (SLC30A) and Zrt‐ and Irt‐like protein (ZIP) (SLC39A) solute‐carrier family in the prostate tissues of different genetically engineered mouse models (GEMM) of PCa (TMPRSS2‐ERG.Ptenflox/flox, Hi‐Myc+/−, and transgenic adenocarcinoma of mouse prostate), their age‐matched wild‐type controls, and 104 prostate core biopsies from human patients with different pathological lesions. Employing immunohistochemistry, differences in the levels of protein expression and spatial distribution of ZNT were evaluated as a function of the tumor stage. Results indicated that the expression of zinc importers (ZIP1, ZIP2, and ZIP3), which function to sequester zinc from circulation and prostatic fluid, was low to negligible in the membranes of the malignant prostate cells in both GEMM and human prostate tissues. Regarding zinc exporters (ZNT1, ZNT2, ZNT9, and ZNT10) that export excess zinc into the extracellular spaces or intracellular organelles, their expression was low in normal prostate glands of mice and humans; however, it was significantly upregulated in prostate adenocarcinoma lesions in GEMM and PCa patients. Together, our findings provide new insights into altered expression of ZNTs during the progression of PCa and indicate that changes in zinc homeostasis could possibly be an early‐initiation event during prostate tumorigenesis and a likely prevention/intervention target.
Investigation on runner resonance and fatigue life of a high–head pump–turbine

The structural stability and fatigue of the runner of a high-head pump-turbine was explored by conducting a numerical simulation of the entire flow passage under different working conditions. A two-way fluid-structure interaction calculation method was used, which captured the values for 5.75fn, 9fn, 13fn, 18fn, and 20fn (fn is rotational frequency) in pressure fluctuation. The resonance of the runner was compared with the results of the modal analysis. The rain flow and damage accumulation methods were used to predict the fatigue life. The study found that the 13fn pressure fluctuation of the fluid in the flow passage of the pump-turbine is the primary cause of the resonance of the runner blade. The main frequency of vibration is the third natural frequency of the runner. The vibration form is up and down along the Z–axis, and there are some high-order resonances. The most vulnerable part of the entire runner is located at the T-shaped connection between the blade inlet edge and the runner crown and bottom ring. The excitation force under the small flow condition is more complicated than that under the large flow condition, which is more likely to cause fatigue damage to the runner. In addition, the damage extent of the high-stress amplitude to the runner is obviously greater than the influence of the number of stress cycles, accounting for approximately 60% of the total damage. The research results can provide a reference for the operational stability and life prediction of a high-head pump-turbine runner.
Preparation and Characterization of Green Porous Palm Shell Based Activated Carbon by Two Step Chemical Activation Using KOH

The large quantity of agricultural waste materials that poses disposal challenge to our environment could be converted into useful products such as activated carbon (AC). Palm oil shell based porous AC was prepared by two step process using KOH as the chemical activant. Palm oil shell was carbonized at 800°C for 2 hours and activated using CO2 at same temperature for 1 hour which yield 23.27% fixed carbon. The AC was characterized by Langmuir surface area, BET surface area and pore volume of 410.7 m2/g, 350 m2/g and 0.2 cm3/g respectively, the FTIR analysis identified the presence of alkanes, carbonyls and hydroxyls as the main functional groups in the AC. Scanning electron microscopy images illustrates the gradual formation of pores from the precursor to the produced AC due to elimination of volatiles and contaminants in the material. However, the AC produced showed basic properties suitable for the removal of hydrophobic organic contaminants in water and wastewater.
The interplay between classifier choice and animacy in Mandarin-Chinese noun phrases: an ERP study

ABSTRACT Animacy is an important semantic assignment principle in both gender and numeral classifier systems. Linguistic research has shown that animacy is not a simple binary feature but represents a fine-grained taxonomy of different animacy levels. We used the classifier system of Mandarin Chinese, with classifiers varying in semantic constraint, to assess whether the referents’ degree of animacy influences the processing of classifier-noun pairs. ERP results show an effect of agreement mismatch only when the general classifier 个 gè is paired with nouns referring to higher animals (chimpanzee, lion). For these pairs, the sortal classifier 只 zhī has to be chosen. No such effect was observed for nouns that refer to intermediate-level and lower animals (octopus, earthworm), indicating that 个 gè does not constitute an agreement mismatch here. We also observed significant ERP effects indicating that speakers of Mandarin Chinese process the general classifier and the specific sortal classifiers differently.
Molecular and Anti-Microbial Resistance (AMR) Profiling of Methicillin-Resistant Staphylococcus aureus (MRSA) from Hospital and Long-Term Care Facilities (LTCF) Environment

To provide evidence of the cross-contamination of emerging pathogenic microbes in a local network between long-term care facilities (LTCFs) and hospitals, this study emphasizes the molecular typing, the prevalence of virulence genes, and the antibiotic resistance pattern of methicillin-resistant Staphylococcus aureus. MRSA isolates were characterized from 246 samples collected from LTCFs, medical tubes of LTCF residents, and hospital environments of two cities, Chiayi and Changhua. Species identification, molecular characterization, and drug resistance analysis were performed. Hospital environments had a higher MRSA detection rate than that of LTCF environments, where moist samples are a hotspot of MRSA habitats, including tube samples from LTCF residents. All MRSA isolates in this study carried the exfoliative toxin eta gene (100%). The majority of MRSA isolates were resistant to erythromycin (76.7%), gentamicin (60%), and ciprofloxacin (55%). The percentage of multidrug-resistant MRSA isolates was approximately 50%. The enterobacterial repetitive intergenic consensus polymerase chain reaction results showed that 18 MRSA isolates belonged to a specific cluster. This implied that genetically similar isolates were spread between hospitals and LTCFs in Changhua city. This study highlights the threat to the health of LTCFs’ residents posed by hospital contact with MRSA.
Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis

Structural disturbances of the subchondral bone are a hallmark of osteoarthritis (OA), including sclerotic changes, cystic lesions, and osteophyte formation. Osteocytes act as mechanosensory units for the micro-cracks in response to mechanical loading. Once stimulated, osteocytes initiate the reparative process by recruiting bone-resorbing cells and bone-forming cells to maintain bone homeostasis. Osteocyte-expressed sclerostin is known as a negative regulator of bone formation through Wnt signaling and the RANKL pathway. In this review, we will summarize current understandings of osteocytes at the crossroad of allometry and mechanobiology to exploit the relationship between osteocyte morphology and function in the context of joint aging and osteoarthritis. We also aimed to summarize the osteocyte dysfunction and its link with structural and functional disturbances of the osteoarthritic subchondral bone at the molecular level. Compared with normal bones, the osteoarthritic subchondral bone is characterized by a higher bone volume fraction, a larger trabecular bone number in the load-bearing region, and an increase in thickness of pre-existing trabeculae. This may relate to the aberrant expressions of sclerostin, periostin, dentin matrix protein 1, matrix extracellular phosphoglycoprotein, insulin-like growth factor 1, and transforming growth factor-beta, among others. The number of osteocyte lacunae embedded in OA bone is also significantly higher, yet the volume of individual lacuna is relatively smaller, which could suggest abnormal metabolism in association with allometry. The remarkably lower percentage of sclerostin-positive osteocytes, together with clustering of Runx-2 positive pre-osteoblasts, may suggest altered regulation of osteoblast differentiation and osteoblast-osteocyte transformation affected by both signaling molecules and the extracellular matrix. Aberrant osteocyte morphology and function, along with anomalies in molecular signaling mechanisms, might explain in part, if not all, the pre-osteoblast clustering and the uncoupled bone remodeling in OA subchondral bone.
Role of Vitamin D Supplementation in Allergic Rhinitis

Background: Allergic Rhinitis (AR) is one of the inflammatory diseases of the nasal mucosa, caused by immunoglobulin E (IgE) after allergens exposure, Severity measurement of the AR symptoms can be conducted subjectively by counting the total nasal symptom score (TNSS) and objectively by counting the serum IgE levels. Vitamin D (VD) plays a significant part in inborn and adaptive immunity; however, this is not completely understood. It is reported that over 900 genes are regulated by VD. The aim of this study is to assess the role of VD supplementation in AR. Methods: This prospective randomized controlled study was carried out on 90 patients Test group (n = 45): received standard medications and supplementation of oral VD3 (cholecalciferol; 1000 IU) for 3 months. Control group (n = 45): received standard medications without supplementation of oral VD3. Results: Comparison between both groups showed insignificant difference between both groups in VD level at the start of the study. According to TNSS in test group, there was significant improvement after 3 months compared to before the study. According to TNSS in control group, there was significant improvement after 3 months than before the study. There was significant improvement in test group than control group as regard to TNSS after 3 months. Conclusions: There was highly significant reduction in the TNSS after VD supplementation. Thus, VD supplementation alters the course of AR towards clinical improvement.
SIMPLIFIED NUMERICAL ANALYSIS OF SUSPENSION BRIDGES

Discretization methods are widely used in the analysis and design of suspension bridges. However, the large number of variables involved do not normally allow examination of the influence of different parameters on the behavior of suspension bridges. This paper presents a numerical method of analysis of suspended cables under vertical loads. Both explicit equilibrium and tangent stiffness matrices are derived by the finite element method. The expressions are also presented in dimensionless form, so that parametric studies can be performed. The obtained matrices can be assembled easily in a general structural analysis computer program. The proposed method is applied to the simplified analysis of suspension bridges. Some dimensionless charts are given for a single span suspension bridge. These include displacement and bending moments under the position of a concentrated load, pseudoinfluence line of displacement and bending moments at the quarter of span, and maximum displacements and bending moments for an arbitrarily located distributed load. It is believed that these charts can be useful in the first phase of design of suspension bridges and can contribute to the understanding of suspension bridge behavior.
Phytochemical profiling and antioxidant, enzyme-inhibitory, and toxic activities of extracts from Adonis ramosa Franch

Abstract This study investigated the content and biological activity of three solvent extracts of Adonis ramosa Franch (AR), which contains 12 types of phytochemicals. The overall yield and total protein content of the aqueous extract were the highest, and it exhibited the highest hydroxyl and superoxide radical-scavenging abilities, copper chelating abilities, and cupric reducing antioxidant capacity. Ethanol extract had the highest total phenolic, flavonoid, and carbohydrate contents, and it showed the highest iron chelating activity, and HClO- and nitrite-scavenging abilities. Methanol AR extract contained the highest total steroid and tannin contents; it also demonstrated high radical- and reactive oxygen species-scavenging abilities and had the best ferric reducing antioxidant power, which allowed it to effectively prevent β-carotene bleaching. Methanol extract also showed good stability and low toxicity. All tested solvent extracts of AR exhibited weak enzyme-inhibitory activities for four enzymes (α-glucosidase, α-amylase, acetylcholinesterase and butyrylcholinesterase). Overall, AR can serve as a natural antioxidant. Graphical Abstract
Dupilumab for the treatment of atopic dermatitis in transplant patients: Two case reports and literature review

Dear Editor, Dupilumab, a monoclonal antibody approved for the treatment of moderate-to-severe atopic dermatitis (AD), has a good safety profile. Its contraindications are very few, such as known hypersensitivity to dupilumab or any of the excipients. Currently, there are sporadic reports of dupilumab use in solid organ transplant recipients (Table 1). We report two transplant patients affected by AD and treated with dupilumab. The first, a 52-year-old male was referred to us for a 10-month history of eczema localized to the trunk and limbs. After clinical and histological evaluation, adult-onset AD was diagnosed. Ten years before, chronic kidney disease had been diagnosed and treated with hemodialysis. At the time of the visit, the patient was on a renal transplant waiting list. Dermatological examination revealed a severe widespread AD (Eczema Area and Severity Index [EASI]:30) with intense pruritus (Pruritus-Numerical Rating Scale [P-NRS]:10) and negative impact on sleep (sleep(S)-NRS:8) and quality of life (Dermatology Life Quality Index [DLQI]:22). In January 2021, labeled dose of dupilumab was started. At 4-week follow-up visit, patient showed significant improvements of AD (EASI:10; P-NRS:5; S-NRS:4; DLQI:5), reaching almost complete remission of signs and symptoms after 20-week therapy (EASI:5; P-NRS:2; S-NRS:0; DLQI:2). In June 2021, dupilumab was suddenly discontinued, because patient underwent cadaveric renal transplantation and started anti-rejection immunosuppressive therapy with everolimus 3 mg/day and tacrolimus 3 mg/day. In September 2021, the patient showed a relapse of AD (EASI:17; P-NRS:8; SNRS:6; DLQI:12). Therefore, based on the benefit–risk assessment and in coordination with the transplant team, we restarted the administration of dupilumab with a significant skin clearance already after 1 month (EASI:2; P-NRS:0; S-NRS:0; DLQI:2). Currently, transplantrelated outcomes are good, and the patient is in stable conditions. The second case is that of an 18-year-old female affected with AD since the first months of life. At the age of 1 year, she had undergone liver transplant surgery for congenital biliary atresia and was currently treated with tacrolimus 3 mg/day and mycophenolate mofetil 3 g/day. At our first visit, she presented with diffuse itchy eczema (EASI:28; P-NRS:8; S-NRS:7; DLQI: 27). Therapy with dupilumab at labeled dosage was started. After 16 weeks, the patient's considerably improved (EASI:3; PNRS:1; S-NRS:0; DLQI: 5). The patient is treated since 3 years with dupilumab, without any apparent influence of