Miracle-dz/UniFAR-FTUs huggingface dataset:
BLOOD ZINC LEVEL IN CHILDREN WITH COMBINED GASTROESOPHAGEAL REFLUX DISEASE AND CHRONIC GASTRODUODENAL PATHOLOGY

Pathology of the upper digestive tract is the most common among gastroenterological diseases in children of different ages and is 48-50 %. Recently, there has been an increase in combined lesions of the esophagus and organs of the gastroduodenal zone. Currently, microelements are considered to play a role in the etiopathogenesis of the diseases of the gastrointestinal tract. The aim of the work was to study zinc level in the blood of children with combined gastroesophageal reflux disease (GERD) and chronic gastroduodenal pathology. Materials and methods . 110 children with combined GERD and lesions of the gastroduodenal zone at the age of 10–18 years were under observation. In order to verify the diagnosis, esophagogastroduodenoscopy was performed. The level of zinc in the blood of children was studied using photometric method. Results . 52.5 % of children with concomitant GERD and chronic gastroduodenal pathologies had a reduced zinc level in the blood. According to the results of the study, the risk factors of zinc deficiency in children with combined pathology of the upper digestive tract include male sex, age older than 14 years, the duration of the disease longer than 3 years. The level of zinc in the blood of children was significantly reduced in destructive lesions of the esophagus, as well as with more pronounced inflammation of the gastric mucosa, in duodenitis and erosions in the duodenal bulb. Conclusions. Thus, the results of the study showed the importance of studying the level of zinc in the blood of patients with combined GERD and chronic gastroduodenal pathology to achieve positive changes by its correction. Zinc deficiency more often develops in boys over 14 year old, who has inflammatory changes of digestive tract.
Value Stream Analysis in Military Logistics: The Improvement in Order Processing Procedure

Military logistics is a complex process where response times, demand uncertainty, wide variety of material references, and cost-effectiveness are decisive for combat capability. The demanding flexibility can only be achieved by improving supply chain management (SCM) to minimize lead times. To cope with these requirements, lean thinking can be extended to military organizations. This research justifies and proposes the use of lean methodologies to improve logistics processes with the case study of a military unit. In particular, the article presents the results obtained using value stream mapping (VSM) and value stream design (VSD) tools to improve the order processing lead time of spare items. The procedure starts with an order generation from a military unit that requests the material and ends before transportation to the final destination. The whole project was structured, considering the define–measure–analyze–improve–control (DMAIC) problem-solving methodology. The results show that the future state map might increase added-value activities from 44% to 70%. After implementation, it was demonstrated that the methodology applied reduced the lead-time average and deviation up to 69.6% and 61.9%, respectively.
Biomarkers of Psoriatic Arthritis Phenotypes

Background: Psoriatic arthritis (PsA) is a chronic heterogenous inflammatory arthritis with five phenotypes. The two least studied phenotypes are investigated in this thesis, including: psoriatic spondyloarthropathy (PsSpA) and psoriatic arthritis mutilans (PAM). The aims of this thesis were to determine the prevalence, clinical characteristics and radiographic characteristics of PsSpA and PAM in a cohort of PsA patients, and serum-soluble bone- turnover biomarkers of these phenotypes. Aims: Comparisons were made with PsA patients without axial disease (pPsA), and ankylosing spondylitis (AS) patients. Methods: A prospective single-centre cross-sectional study was conducted of PsA and AS patients. Serum on psoriasis-only patients (PsC) and healthy controls (HC) were also obtained. Multivariate clinical, radiographic, genetic and serum biomarker comparisons were made between these five groups of subjects. Results: The study enrolled 201 PsA and 201 AS patients, who were then reclassified as 118 PsSpA, 127 pPsA and 157 AS cases, alongside 200 PsC and 50 HC subjects. Several clinical biomarkers, imaging biomarkers, serum-soluble biomarkers and genetic biomarkers were identified that differentiate PsSpA from pPsA and AS. PsSpA affected a significant proportion of PsA patients, and was not a milder version of AS. PsSpA involvement was as disabling and clinically impactful as AS. PAM was found to be associated with PsSpA, and clinical biomarkers of PAM occurrence and radiographic progression were identified. Conclusions: In conclusion, this thesis indicates that PsSpA is on a spectrum of musculoskeletal disease, in between pPsA and AS; with PsSpA comprising a continuum itself, and with a phenotype expression related to disease duration. These findings may prompt the inception of an international-consensus classification system for PsSpA, for which there is a great clinical need. Given that PsSpA has its own discrete clinical and biomarker signature, its clinical management and research should be tailored from that of pPsA and AS. Ultimately this may further the effort for stratified and personalised medicine.
Outcomes after Treatment of Metaplastic Versus Other Breast Cancer Subtypes

Purpose: Metaplastic breast cancer (BC) is an uncommon yet aggressive histologic subtype of BC. We sought to identify factors associated with its diagnosis and compare the management and outcomes of metaplastic BC with those of other BCs and triple negative invasive ductal carcinoma in particular given how often it has a triple negative phenotype. Patients and Methods: We identified women diagnosed with invasive BC in 2010-2014 in the National Cancer Data Base, and used univariate analysis to compare baseline patient and tumor characteristics by BC subtype. Overall survival (OS) was estimated with the Kaplan-Meier method, and multivariate Cox proportional hazards models were used to identify independent predictors of OS. Results: Of 247,355 cases, 2,084 (0.8%) were metaplastic BC, 55,998 (23%) triple negative BC, and 77% other BC. Relative to non-metaplastic BC, women with metaplastic BC were more likely to be older at diagnosis (median age, 62 vs. 59 years), have ≥1 comorbid conditions (22% vs. 18%), and be on Medicare (41% vs. 33%; P<0.001). Metaplastic BCs tended to be basal-like (77%), and relative to triple-negative or other BC, metaplastic BC was associated with higher clinical T status (cT3-4, 18% vs. 11%, 8%), no clinical nodal involvement (cN0, 86%, 77%, 80%), no lymphovascular invasion (72%, 65%, 62%), and high-grade tumors (71%, 77%, 35%) (P<0.001). Most metaplastic BCs were treated with mastectomy (58%), sentinel lymph node dissection (65%), chest wall or breast irradiation (74%), and chemotherapy (75%) as adjuvant therapy (60%). At a median follow-up time of 44.5 months, OS rates were lower for metaplastic BC than for triple-negative or other BC across all clinical stages at 5 years (stage I, 85%, 87%, 91%; II, 73%, 77%, 87%; III, 43%, 53%, 75%) and at 3 years (Stage IV, 15%, 22%, 64%; P<0.001). On multivariate analysis, increasing age, advanced clinical stage, lymphovascular invasion, axillary (vs. sentinel) node dissection, and no radiation or chemotherapy were associated with worse outcomes in metaplastic BC. Extent of surgery affected survival for triple-negative and other BC but not for metaplastic BC. Conclusion: Outcomes for metaplastic BC continue to be worse than those for other BC subtypes despite modern treatments. Optimizing systemic therapy options, which was a significant predictor of survival, should be a priority in managing metaplastic BC.
The Relation between Hearing Loss and Smoking among Workers Exposed to Noise, Using Linear Mixed Models

Introduction: Noise is one of the most common and harmful physical factors in the working environment and has physical and psychological effects on individuals. In this study, the audiometry results of industrial workers were modeled and the effect of noise and other factors on hearing loss was examined. Materials and Methods: This was a longitudinal study based on the records of workers who had worked over 10 years in the industry and had recorded audiometries since their employment. Data was analyzed through linear mixed models. Results: During each year of noise exposure, hearing loss was 1.9 db at 4000 Hz; 0.059 in low frequencies and 0.62 db in high frequencies. At 8000 Hz the effect of the age at employment on hearing loss was significant (P=0.014). At low frequencies the interaction of smoking and age at employment was significantly related to hearing loss (P˂0.001). Conclusion: This study showed that despite acquaintance with safety measures, workers still face hearing loss in industry and employers should put workers under more surveillance for using protective gear. Smoking might be another risk factor for hearing loss.
Restriction Site Associated DNA Sequencing based Single Nucleotide Polymorphism Discovery in Selected Tef (Eragrostis tef) and Wild Eragrostis Species

አህፅሮት ጤፍ በኢትዮጵያ የተገኘ እና በኢትዮጵያዊያን አርሶአደሮች ለብዙ አመታት ሲመረት የኖረ ዘርፈ ብዙ ጥቅሞች ያሉት የሰብል አይነት ነዉ፡፡ ጤፍ የሚመረተውና ጥቅም ላይ የሚውለው በአብዛኛው በኢትዮጵያ በመሆኑ በአለም አቀፍ ደረጃ ጤፍ ላይ የሚደረጉ ምርምሮች ውሱን ናቸው፡፡ በተለይ የጤፍን ምርምር ለማሳለጥ የተዘጋጁ የሞለኪውላር ሳይንስ ግብአቶች ውሱን በመሆናቸው በሌሎች ሰብሎች ላይ ጥቅም ላይ የዋሉ የዲ ኤን ኤ ሲኩዌንሲንግ ቴክኖሎጂን መሰረት ያደረጉ የምርምር አቅጣጫዎችን መከተል ወሳኝ ነው፡፡ እዚህ በቀረበው የምርምር ስራ የዲ ኤን ኤ ሲኩዌንሲንግ ቴክኖሎጂን መሰረት ያደረገን የምርምር ስልት በመከተል ከአገሪቱ የተለያዩ አካባቢዎች የተሰበሰቡ አርባ ሁለት የጤፍ ዝርያዎች፡ አንድ ሚውታንት ላይን እና ሁለት ለጤፍ ቅርብ የሆኑ ዋይልድ ሬላቲቭስ ላይ ጥናት ተደርጎ የጤፍን ምርምር በዘመናዊ መልኩ የሚያግዙ ግብአቶች ተገኝተዋል፡፡ Abstract Genome-wide knowledge about the nature and extent of genetic diversity present in tef (Eragrostis tef), the most consumed food grain in Ethiopia is limited. Adopting next generation sequencing (NGS) protocols to enhance its genomics and breeding is essential. Here, we applied the Restriction Site Associated DNA (RAD) sequencing protocol and surveyed the genomes of 43 tef landraces, one mutant line and two wild Eragrostis species. After mapping sequencing reads to the de novo assembled unitag and the tef reference genome, a total of 9,024 and 58,735 high quality single nucleotide polymorphisms (SNPs) were identified, respectively. We identified greater number of SNPs and greater nucleotide diversity in the two wild Eragrostis species than in the tef landraces. The tef landrace populations in this study were poorly differentiated with F ST values of 0.015. In the phylogenetic analysis, grouping of the landraces was not consistent with the area of collection, but few localized grouping of the landraces was evident, probably showing the communality of tef seed use across geographical boundaries. The improved tef varieties show reduced genetic diversity compared to the landraces and were all grouped into one cluster reflecting the nature of tef breeding which largely targets common genomic regions. We suggest that future work needs to aim beyond common genomic regions. The work presented here is a valuable addition to the growing molecular resources developed for tef genetic improvement.
The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer

Oxaliplatin (OXA) resistance is the major obstacle to the anticancer effects of chemotherapy in colorectal cancer (CRC) patients. MicroRNAs (miRNAs) play an important role in the chemoresistance of various tumors. Our objective is to clarify the underlying mechanism of miRNAs in chemoresistance and provide a potential strategy to improve the response of CRC patients to chemotherapeutics. Methods: MiRNA microarray and Real-time PCR were performed to compare changes in miRNA expression between oxaliplatin-resistant and the parental cells. CCK8, apoptosis assay, immunofluorescence and xenograft studies were used to elucidate the impact of miR-27b-3p on regulating chemoresistance. Luciferase reporter assay and western blot were carried to assess the regulatory role of miR-27b-3p in ATG10 expression. The effects of miR-27b-3p and ATG10 on autophagy were investigated by GFP-LC3 fluorescence microscopy, transmission electron microscopy, and western blot. ChIP assay and luciferase assay were performed to test the c-Myc's occupancy on the miR-27B promoter. Results: We observed that miR-27b-3p expression was significantly downregulated in oxaliplatin-resistant cell lines (SW480-OxR and HCT116-OxR) compared to the corresponding parental cell lines and that miR-27b-3p expression was positively correlated with disease-free survival (DFS) time in colorectal cancer patients. MiR-27b-3p could sensitize colorectal cancer cells to oxaliplatin in vitro and in vivo. Under oxaliplatin treatment, chemoresistant cells showed a higher autophagy level than parental cells. Moreover, we also identified that miR-27b-3p inhibited the expression of ATG10 at the posttranscriptional level, thus inhibiting autophagy. Further study demonstrated that c-Myc can inhibit the expression of miR-27b-3p via binding to the promoter region of miR-27B gene. Conclusions: Our study identifies a novel c-Myc/miR-27b-3p/ATG10 signaling pathway that regulates colorectal cancer chemoresistance. These results suggest that miR-27b-3p is not only a potential indicator for evaluating efficiency of chemotherapy, but also a valuable therapeutic target for CRC, especially for patients with chemoresistance.
Effect of Strain on External and Internal Egg Parameters of Exotic, Indigenous Chicken and Crossbreds

Examining effect of Strain on External and Internal Egg Parameters of Rhode Island Red (RIR), two Nigerian indigenous chicken strain:-(Pure naked neck (NNK); pure Normal feathered (NF)); Crosses were:RIR x naked neck (RNK) cross; RIR x Normal feathered (RNF) cross. Matured 100 birds reared intensively for 10 weeks at Teaching and Research farm, University of Uyo in a Completely Randomized Design in standard management practices. Feed (16.0% crude protein, 2800 Kcal/Kg Metabolize-able energy) and water given ad libitum. 10 eggs per strain were cracked every Mondays and Fridays every week to examined External (egg weight(Ewt), egg length(El), shell weight (Swt) and Internal (yolk height (Yht), yolk weight(Ywt), albumen weight(Awt) albumen height (Aht) and Haugh unit (HU)) egg parameters. All data were subjected to one-way Analysis of Variance of SAS Statistical Software Package Version 9.2. Results indicated significant (P<0.05) effect of strain on external egg parameters studied. For Ewt, RNK (46.38±0.79 g) and RNF (45.54±0.96 g) were statistically (P<.05) higher than NF (42.42±0.85 g). For Swt, RNF(4.71g±0.09 g) was statistically (P<.05) higher than NF (4.36±0.11g) but similar in other strains. Result indicated significant (P<0.05) effect of strain on all the internal egg parameters measured. For Hu (RNK) 79.08±1.23% and (RNF) 77.83±1.88 were statistically (P<.05) higher than (NF) 73.84±1.10%. The same trend followed in other internal egg parameters among the strains. Generally, the trends Original Research Article Ezekiel and Hilary; CJAST, 38(6): 1-7, 2019; Article no.CJAST. 53186 2 placed were exotic birds first, then Crossbreds and Purebreds last in the parameters. In conclusion, RNK and SNF crossbreds performed better in both External and Internal egg parameter than purebred strains studied. Hence, crossbreeding should be adopted to improve Nigerian Chickens.
Comparison of Indonesian Imports Forecasting by Limited Period Using SARIMA Method

The development of Indonesia's imports fluctuate over years. Inability to anticipate such rapid changes can cause economic slump due to inappropriate policy. For instance, recent years imports in rice led to the extermination of rice reserves. The reason is to maintain the market price of rice in Indonesia. To overcome these changes, forecasting the amount of imports should assist the Government in determining the optimum policy. This can be done by utilizing an algorithm to forecast time series data, in this case the amount of imports in the next few months with a high degree of accuracy. This study uses data obtained from the official website of the Indonesian Ministry of Trade. Then, Seasonal Autoregressive Integrated Moving Average (SARIMA) method is applied to forecast the imports. This method is suitable for the interconnected dependent variables, as well as in forecasting seasonal data patterns. The results of the experiment showed that 6-period forecast is the most accurate results compared to forecasting by 16 and 24 periods. The research resulted in the best model, that is ARIMA (0, 1, 3)(0, 1, 1)12 produces forecasting with a MAPE value of 7.210 % or an accuracy rate of 92.790 %. By applying this imports forecast model, the government can have a forward strategic plans such as selectively imports products and carefully decide the amount of the incoming products to Indonesia. Hence, it could maintain or improve the economic condition where local businesses can grow confidently.
AERODYNAMIC RESULTS FOR A NOTCHBACK RACE CAR

The use of numerical simulations is nowadays drawing an increasing interest in aerodynamic shape optimization. We firstly present a thorough benchmark of different numerical experiments done with Fluent, CFX, OpenFOAM and PowerFLOW on the Ahmed body in order to select the proper model and numerical scheme for our needs. Numerical strategies for reducing preparation, discretization, simulation and time optimization are also shown. Secondly, results around a NACA airfoil are discussed. As an application we consider the air flow around a notchback race car. The results presented show that the chosen strategy is able to accurately predict drag, lift and aerodynamic efficiency with low computational cost.
Frequency of Selenomonas Noxia in Oral Microbiota of Obese and Normal Weight People in Duhok-Iraq

Obesity represents one of the major problematic health issues worldwide. Recent evidences suggest that obesity is related with the alteration of the oral microbiome. The aim of this study was to measure the salivary bacterial Selenomonas noxia in Duhok population. A total of 155 saliva samples were collected from individuals (aged between 19-35 years) of both genders (86 females and 69 males). The individuals were divided into three groups (obese, overweight, and normal weight) based on their body mass index. Bacterial genomic DNA was extracted from saliva samples. Molecular detections of Selenomonas noxia were performed by the polymerase chain reaction. Among the 155 participants, 34.1% were obese, 26.4% overweight and 39.3% normal weight individuals. The prevalence rate of oral S. noxia among all people was 82.6%. The highest rate of S. noxia was in obese people (86.8%), followed by overweight (85.4%) and normal weight people (77%). The prevalence of S. noxia in overweight people was statistically significant in compare with the normal weight people (p<0.0001). Moreover, the oral carriage of S. noxia was highest among the overweight females (94.5%) followed by obese females (88.9%). However, no significant difference was found compared to males. The result revealed that it is possible to assume that the expansion of S. noxia in saliva is due to obesity. Moreover, the composition of salivary microbiome may lead to the risk that the overweight group is at risk of future obesity. However, further investigations are required with larger sample and participants with different socioeconomic status in order to address the exact link between obesity and oral bacteria. This could lead to a new and promising therapeutic way for improving human's health.
A study of 25-year old women

Background: Osteoporosis is a common bone disease, which does not give symptoms until the ultimate outcome, the fragility fracture occurs. Re gulatio n of bon e mass is controlied by genetic, environmental ap d nu tritional influences. Peak bon e mass, defined as the maximum bon e mass accrued, is usually reached by the third decade of Iife and is an im portant determinant of future osteoporotic fracture. A number of lifestyle factors, among them physical activity and smoking and even weight at birth are associated with bone mass. However, to what extent the se factors are associated to bon e mass in young age, peak bon e mass, are less clear. Aims: To evaluate peak bone mass and its association with birth weight, recreational levels of physical activity and smoking. To evaluate how bone mass in Swedish young adult women compares with other similarly aged populations and the DXA manufacturer suppli ed reference values. Methods: 1061 women, aged 25 years at inclusion, were recruited to the PEAK-25 cohort. All partidpants were measured with DXA. In addition a comprehensive lifestyle questionnaire was completed, including detailed data on physical activities and smoking. Birth anthropometrics were obtained from the Swedish National Board ofHealth and Welfare. Results: The BMD values of the PEAK-25 cohort were generally higher than equivalently aged European and North American cohorts and the reference cohort incorporated for reference in the DXA scanner. Women with lower birth weight had lower bone mineral content and lower birth weight appears to have a greater negative influence on bone mass than the positive influence of higher birth weight. Recreational levels of physical activity were found to be associated with higher peak bone mass and BMD gains were maximized through regular, high-impact exercise. We found that the quantity of cigarettes consumed, but not smoking duration, is negatively associated with peak bone mass. BMI increases with longer smoking duration and may partly reduce the adverse effects of smoking on bone. Conclusions: If available, ethno-geographically obtained reference data should be used in order to receive more appropriate results from DXA scanning and improve diagnostic accuracy. We have identified risk factors associated with peak bon e mass which have the potential for modification. Pro m oting physical activity, even on recreational level, will have beneficial influence on peak bon e mass. Furthe r, if not complete cessation of smoki ng, a reduced number of cigarettes may have beneficial effects on bon e health. For bon e prornating measures, children with low birth weight ought to obtain additional support.
Dopaminergic D1 receptors in the nucleus basalis modulate recovery from propofol anesthesia in rats

Objective(s): Melatonin, an important hormone secreted by the epiphysis, is a powerful anti-oxidant with a high potential to neutralize medical toxins. The goal of this study was to demonstrate the beneficial effect of melatonin on epididymal sperm and reproductive parameters in mice treated with acetylsalicylic acid (ASA). Materials and Methods: Thirty-nine SD rats were randomly split into D1 receptor agonist (chloro-APB), D1 receptor antagonist (SCH23390), and saline groups after preparing NB microinjection model. We observed the effect of NB microinjection of SCH23390, chloro-APB, or saline on the period of induction and recovery time of propofol anesthesia and recorded the changes of electroencephalogram (EEG) simultaneously. Results: NB microinjection of chloro-APB accelerated the recovery from propofol anesthesia (P<0.05), without affecting the induction of anesthesia (P>0.05); NB microinjection of SCH23390 produced the opposite effects. NB microinjection of saline did not influence the induction or recovery of propofol anesthesia (P>0.05). NB injection of chloro-APB decreased the ratio of δ power and increasedαand β ratios in prefrontal cortex EEG (P<0.05); NB microinjection of SCH23390 increased δ ratio and decreased β ratio (P<0.05); NB microinjection of saline had no significant effect on EEG (P>0.05) Conclusion: D1 dopamine receptors in NB are involved in modulating the emergence from propofol anesthesia, but not affecting the induction of propofol anesthesia.