Miracle-dz/UniFAR-FTUs huggingface dataset:
Key demographics and psychological skills associated with adjustment to progressive Multiple Sclerosis early in the diagnosis

Background/purpose Being diagnosed with a progressive type of multiple sclerosis (MS) has been associated with worse psychological outcomes compared to relapsing-remitting type. Previous studies of adjustment to MS have primarily focused on relapsing-remitting type MS. The present study aims to examine psychological adjustment for people newly diagnosed with progressive multiple sclerosis. Methods This was a multicenter cross-sectional survey of 189 people newly diagnosed with progressive MS. A composite measure of psychological adjustment was created from questionnaires measuring psychological distress, positive affect, perceived-stress, life satisfaction and self-concept. Predictor variables included coping strategies, social support, relationship with partner, psychological vulnerability, MS-related beliefs, and responses to symptoms. Data were analysed using a regularised regression model to indicate which group of all variables are associated with adjustment. Results People who were older (b = 0.17(0.07), p = 0.02), in employment (b = 0.40 (0.17), p = 0.01), and with lower illness severity (b = −0.24 (0.08), p = 0.001) showed better adjustment. Based on a Lasso regression, the most important psychological and demographic variables associated with lower adjustment (out-of-sample cross-validation R2 = 62.6%) were lower MS self-efficacy and higher avoidance, cognitive vulnerability, embarrassment avoidance, conflict, helplessness, and secondary progressive MS type. Conclusions and implications Helping newly diagnosed people to find ways to tolerate anxiety-causing situations by encouraging acceptance may help people adjust to progressive MS by lowering their avoidance. Further, building confidence in managing the illness and addressing relationship issues are key focus areas in psychological interventions for people with progressive multiple sclerosis.
Bacillus amyloliquefaciens GB03 augmented tall fescue growth by regulating phytohormone and nutrient homeostasis under nitrogen deficiency

Nitrogen is an important nutrient for plant growth and development. Soil microorganisms have been used to curb the imbalance between the limited content of natural environmental nitrogen and the pollution caused by increasing nitrogen fertilizer use in ecologically fragile areas. Bacillus amyloliquefaciens GB03 has been shown to confer growth promotion and abiotic stress tolerance in Arabidopsis thaliana. This study provided a new insight into the role of the plant growth-promoting rhizobacterium B. amyloliquefaciens GB03 as an initiator of defense against nitrogen deficiency in non-leguminous grass tall fescue (Festuca arundinacea). Two-week-old seedlings of tall fescue were grown with or without GB03 for 4 weeks under total nitrogen (3.75 mM NO3 -) or low nitrogen (0.25 mM NO3 -) treatment. Growth parameters, chlorophyll content, endogenous total nitrogen, total phosphorus content, and phytohormone content, including those of auxin indole-3-acetic acid, cytokinin, gibberellic acid, and abscisic acid, were determined at the time of harvest. Tall fescue grown in GB03-inoculated soil was more robust than the non-inoculated controls with respect to plant height, root length, plant biomass, chlorophyll concentration, and nutrient (total nitrogen and total phosphorus) contents under total nitrogen treatment. GB03 increased indole acetic acid content by 24.7%, whereas decreased cytokinin and abscisic acid contents by 28.4% and 26.9%, respectively, under a total nitrogen level. Remarkably, GB03 increased indole acetic acid content by more than 80% and inhibited abscisic acid production by nearly 70% under a low nitrogen level. These results showed, for the first time, that GB03 played a crucial role in mediating NO3 –dependent regulation of tall fescue growth and development, especially revealing the mechanism of soil bacteria improve resistance to nitrogen deficiency stress in non-nitrogen-fixing species.
Exploring surface electromyography (EMG) as a feedback variable for the human-in-the-loop optimization of lower limb wearable robotics

Human-in-the-loop (HITL) optimization with metabolic cost feedback has been proposed to reduce walking effort with wearable robotics. This study investigates if lower limb surface electromyography (EMG) could be an alternative feedback variable to overcome time-intensive metabolic cost based exploration. For application, it should be possible to distinguish conditions with different walking efforts based on the EMG. To obtain such EMG data, a laboratory experiment was designed to elicit changes in the effort by loading and unloading pairs of weights (in total 2, 4, and 8 kg) in three randomized weight sessions for 13 subjects during treadmill walking. EMG of seven lower limb muscles was recorded for both limbs. Mean absolute values of each stride prior to and following weight loading and unloading were used to determine the detection rate (100% if every loading and unloading is detected accordingly) for changing between loaded and unloaded conditions. We assessed the use of multiple consecutive strides and the combination of muscles to improve the detection rate and estimated the related acquisition times of diminishing returns. To conclude on possible limitations of EMG for HITL optimization, EMG drift was evaluated during the Warmup and the experiment. Detection rates highly increased for the combination of multiple consecutive strides and the combination of multiple muscles. EMG drift was largest during Warmup and at the beginning of each weight session. The results suggest using EMG feedback of multiple involved muscles and from at least 10 consecutive strides (5.5 s) to benefit from the increases in detection rate in HITL optimization. In combination with up to 20 excluded acclimatization strides, after changing the assistance condition, we advise exploring about 16.5 s of walking to obtain reliable EMG-based feedback. To minimize the negative impact of EMG drift on the detection rate, at least 6 min of Warmup should be performed and breaks during the optimization should be avoided. Future studies should investigate additional feedback variables based on EMG, methods to reduce their variability and drift, and should apply the outcomes in HITL optimization with lower limb wearable robots.
Spatial impact of the built environment on street vitality: A case study of the Tianhe District, Guangzhou

Taking the Tianhe District in Guangzhou, China, as a case and the urban street (road) as the basic research unit, this study analyzes the relationship between the built environment and street vitality to analyze the influencing factors of street vitality. The Tencent location service data are used to characterize street vitality, and the OLS and GWR models are used to construct the statistical relationship between the built environment and street vitality after establishing the urban built environment index. The results show that spatial heterogeneity is considered in the GWR model based on local geographic weighting, and its fitting effect is better than that of the OLS model, which can reveal the micro-local characteristics of the built environment’s effect on street vitality. Increasing the land-use mixing degree, new and old building mixing degrees, and land-use intensity (building density and volume ratio) can significantly increase street vitality, which proves to a certain extent that Jacobs’s relevant discussion is still highly practical for the Tianhe District.
Mobile-assisted vocabulary learning through the Shanbay App outside the classroom: Effects of self-regulation and peer scaffolding

Recent decades have witnessed an increasing academic interest in mobile-assisted vocabulary learning. To explore the possible influencing factors on learning outcomes, this study aimed at examining the effects of self-regulation and peer scaffolding on mobile-assisted vocabulary learning among undergraduate students using Shanbay App beyond the classroom. To this end, altogether 71 intermediate-level English learners aged 17–19 years were chosen as participants, with 37 in the experimental group (with peer scaffolding) and 34 in the control group (without peer scaffolding). Data were collected through the Shanbay App regarding participants’ vocabulary learning performance, a self-regulation questionnaire and semi-structured interviews. The results of factorial ANOVA revealed that peer scaffolding significantly affected mobile vocabulary learning in terms of the days spent in vocabulary learning and the sum of words participants have learned; a main effect of self-regulation and an interaction effect of self-regulation and peer scaffolding were also observed on the sum of learned words. The research is innovative in providing a motivational peer scaffolding framework in mobile vocabulary learning settings, and may provide pedagogical implications for vocabulary teaching in EFL context in higher education.
The impact of self-directed team on high-performance organization with the mediating role of knowledge sharing culture: Organizational support as a moderator

The primary aim of this investigation is to identify the relationship between self-directed teams and high-performance organizations (work). Furthermore, exploring the mediating role of knowledge-sharing culture with the self-directed team and high-performance organization relationships. Moreover, this study analyzed the moderating role of a sense of organizational support in the relationship between knowledge-sharing culture and high-performance organizations. Using the PLS-SEM approach (SmartPLS 3.3.7) in this study, we obtained data from employees of high-tech enterprises listed on the Shanghai Stock Exchange China to analyze this study. The present research seeks to determine the direct and indirect effects of the study-related factors on the outcome of the investigation. According to the findings, a self-directed team positively impacts knowledge sharing culture, knowledge sharing behavior, knowledge sharing strategy, and mutual trust among its members. Knowledge-sharing culture has no mediating role and its component in the relationship between independent and dependent constructs. This study also indicated that a sense of organizational support has no moderating effect on the relationship between a knowledge-sharing culture and high-performance organizations. This study may practically contribute to high-tech enterprises to develop and implement business development and proper self-directed team, knowledge-sharing culture, and sense of organizational support, and consequently, can contribute to the growth of overall high-performance organizations.
Creativity in lockdown: Understanding how music and the arts supported mental health during the COVID-19 pandemic by age group

Recent research has indicated that many people around the world turned to artistic creative activities (ACAs) to support their mental health during COVID-19 lockdowns. However, studies have also shown that the negative psychosocial impacts of the pandemic have disproportionately affected young people, suggesting that the use of ACAs to support mental health in lockdown may have varied across age groups. This study investigated how Australians in four different age groups (18–24, 25–34, 35–54, and 55+) engaged in ACAs to support their mental health during the 2020 pandemic lockdowns. Participants (N = 653) recruited from the general public completed an online survey between May and October 2020, in which they reported which ACAs they had undertaken during the pandemic using an established list. Participants subsequently ranked undertaken ACAs in terms of effectiveness at making them “feel better,” and those who had engaged in musical ACAs also completed the Musical Engagement Questionnaire (MusEQ). Additionally, ratings of anxiety (GAD7) and depression (PHQ9) symptoms were obtained and examined for potential variations across four diverse variables: age, exercise, gender and state/territory of residence. ACA rankings showed that younger participants overwhelmingly rated musical activities as most effective, while, with the exception of singing, those aged 55+ rated non-musical activities as being most effective. These differences were further supported by ratings for all six MusEQ subscales, with responses strongly indicating that the youngest participants (aged 18–24) used music in significantly different ways during the pandemic than participants in all other age groups. Specifically, these youngest participants were more likely to integrate music into daily life, use music for emotion regulation, respond to music in embodied ways, and use music to perform a social identity. In line with prior research, further analyses indicated that symptoms of anxiety and depression were lessened for older participants, as well for those who reported exercising more during the lockdowns. These findings provide insight into how ACAs can support mental health during a pandemic crisis for specific age groups, which may inform future policy directions, and suggestions for how this can be done are provided.
A CANDIDATE DETECTION OF THE FIRST HYDROSTATIC CORE

The first hydrostatic core (FHSC) represents a very early phase in the low-mass star formation process, after collapse of the parent core has begun but before a true protostar has formed. This large (few AU), cool (100 K), pressure-supported core of molecular hydrogen is expected from theory, but has yet to be observationally verified. Here, we present observations of an excellent candidate for the FHSC phase: Per-Bolo 58, a dense core in Perseus that was previously believed to be starless. The 70 μm flux of 65 mJy, from new deep Spitzer MIPS observations, is consistent with that expected for the FHSC. A low signal-to-noise detection at 24 μm leaves open the possibility that Per-Bolo 58 could be a very low luminosity protostar, however. We utilize radiative transfer models to determine the best-fitting FHSC and protostar models to the spectral energy distribution and 2.9 mm visibilities of Per-Bolo 58. The source is consistent with an FHSC with some source of lower opacity through the envelope allowing 24 μm emission to escape; a small outflow cavity and a cavity in the envelope are both possible. While we are unable to rule out the presence of a protostar, if present it would be one of the lowest luminosity protostellar objects yet observed, with an internal luminosity of ∼0.01 L☉.
A retrospective study of the correlation between herpes zoster neuralgia and the serum neuron-specific enolase level in the largest dermatological hospital in Zhejiang province, China

We studied the changes and clinical significance of the serum neuron-specific enolase (NSE) level in peripheral blood of patients with post-herpetic neuralgia (PHN). Material and methods Patients with PHN were divided into a mild PHN group and a severe PHN group according to their scores on a 100-point Likert scale representing the degree of neuralgia. NSE levels in neuralgia patients and healthy volunteers were then compared by t-test. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic efficiency of NSE for PHN. The correlation between NSE level and Likert scale score after treatment was analyzed. Results NSE levels in PHN patients were higher than those in the healthy volunteers. Patients in the severe PHN group had higher NSE levels than those in the mild PHN group. NSE level at admission was associated with the Likert scale score recorded on the 14th day of treatment (136.1 ± 32.81 vs. 87.53 ± 16.23 pg/mL) (P < 0.05). The ROC curve of NSE levels for PHN is shown that the area was 0.8713 (95% confidence interval, 0.7861–0.9564; p < 0.0001). Conclusions There was a correlation between NSE and PHN, in that the NSE level positively correlated with the short-term prognosis of patients with PHN.
A comparative study of pre-service teachers’ knowledge and perceptions of, and attitudes toward, inclusive education

This study examined pre-service teachers’ knowledge and perceptions of, and attitudes toward, inclusive education. A total of 131 pre-service teachers from two programs—one at a College of Education and a university program through the Faculty of Education—were surveyed using a cross-sectional survey research design. Data were collected using a self-developed questionnaire. The questionnaire was pilot tested among pre-service teachers from the Faculty of Education at a university which did not participate in the study. We used a 3 × 2 factorial multivariate analysis of variance (MANOVA) to analyze the descriptive and inferential data (means, standard deviations). The study revealed a statistically significant difference between pre-service teachers’ gender (male and female) and programs (university and college of education) regarding their knowledge and perceptions of, and attitudes toward, inclusive education. The results indicated a significant MANOVA. In the follow-up analysis of the variance test, pre-service teachers’ perceptions and attitudes differed between genders and programs. In addition, the study found a significant difference between pre-service teachers’ perceptions and attitudes toward inclusive education based on their educational programs. Pre-service teachers from the College of Education scored higher than those from the Faculty of Education at a university. We discuss the implications of an egalitarian learning environment.
Early development of treatment motivation predicts adherence and symptom reduction in an internet-based guided self-help program for binge eating disorder

Objective Lack of motivation is widely acknowledged as a significant factor in treatment discontinuity and poor treatment outcomes in eating disorders. Treatment adherence is lower in internet-based treatment. The current study aimed to assess the relationship between treatment motivation and treatment outcomes in an internet-based therapist-guided intervention for Binge Eating Disorder (BED). Method Adults (N = 153) with mild to moderate symptoms of BED participated in a 10-session internet-based treatment program. Baseline and between-session scores of “Readiness to change” and “Belief in change” were used to predict treatment completion and eating disorder symptom reduction (EDE-Q Global, BED-Q, and weekly number of binge eating episodes) at post-treatment. Results Baseline treatment motivation could not predict treatment completion or symptom reduction. Early measures of treatment motivation (regression slope from sessions 1–5) significantly predicted both treatment completion and post-treatment symptom reduction. “Belief in change” was the strongest predictor for completing treatment (OR = 2.18, 95%-CI: 1.06, 4.46) and reducing symptoms (EDE-Q Global: B = −0.53, p = 0.001; number of weekly binge eating episodes: B = 0.81, p < 0.01). Discussion The results indicated that patients entering online treatment for BED feel highly motivated. However, baseline treatment motivation could not significantly predict treatment completion, which contradicts previous research. The significant predictive ability of early measures of treatment motivation supports the clinical relevance of monitoring the development of early changes to tailor and optimize individual patient care. Further research is needed to examine treatment motivation in regard to internet-based treatment for BED with more validated measures.
Isolation of ferret astrocytes reveals their morphological, transcriptional, and functional differences from mouse astrocytes

Astrocytes play key roles in supporting the central nervous system structure, regulating synaptic functions, and maintaining brain homeostasis. The number of astrocytes in the cerebrum has markedly increased through evolution. However, the manner by which astrocytes change their features during evolution remains unknown. Compared with the rodent brain, the brain of the ferret, a carnivorous animal, has a folded cerebral cortex and higher white to gray matter ratio, which are common features of the human brain. To further clarify the features of ferret astrocytes, we isolated astrocytes from ferret neonatal brains, cultured these cells, and compared their morphology, gene expression, calcium response, and proliferating ability with those of mouse astrocytes. The morphology of cultured ferret astrocytes differed from that of mouse astrocytes. Ferret astrocytes had longer and more branched processes, smaller cell bodies, and different calcium responses to glutamate, as well as had a greater ability to proliferate, compared to mouse astrocytes. RNA sequencing analysis revealed novel ferret astrocyte-specific genes, including several genes that were the same as those in humans. Astrocytes in the ferret brains had larger cell size, longer primary processes in larger numbers, and a higher proliferation rate compared to mouse astrocytes. Our study shows that cultured ferret astrocytes have different features from rodent astrocytes and similar features to human astrocytes, suggesting that they are useful in studying the roles of astrocytes in brain evolution and cognitive functions in higher animals.
Data evaluation of broiler chicken rearing and slaughter—An exploratory study

To process and evaluate the data from broiler fattening and slaughtering, we investigated the production data of 107 straight run flocks of the commercial meat-type breed Ross 308 (Aviagen, EU). All flocks were raised and slaughtered in Germany and the average slaughter age was 37 days. The health outcomes of interest were mortality, average weight, and the slaughter results. First-week mortality, cumulative mortality, stocking density, flock size, season, production week of the parental flock, farm, antibiotic treatment, and the interaction between antibiotic treatment and season were considered as possible influencing factors. The average first-week mortality (FWM) and cumulative mortality percentages were 0.66 and 2.74%, respectively. First-week mortality was influenced by flock size, production week of the parental flock, and the interaction between antibiotic treatment and season, whereas cumulative mortality was influenced by antibiotic treatment, farm, and first-week mortality. The average weight (mean 2.30 kg) was influenced by season, stocking density, flock size, farm, and the interaction between antibiotic treatment and season. The condemnation rate was on average 1.48%, with the most common causes being deep dermatitis (mean 0.63%), ascites (mean 0.53%), and not suitable for production/general disease (mean 0.25%). Several factors influenced the causes of condemnation, with season being the most predominant one, followed by the interaction between antibiotic treatment and season, the antibiotic treatment alone, and stocking density.
The heterogeneity of negative problem orientation in Chinese adolescents: A latent profile analysis

Negative problem orientation (NPO) has become an essential construct for comprehending social problem-solving deficits. However, the heterogeneity of NPO has not yet been explored. With a sample of Chinese adolescents (N = 2,174), four latent profiles were identified as lower NPO, moderate NPO, self-inefficacy and negative outcome expectancy (SI&NOE), and dysfunctional NPO. Compared to the lower NPO and moderate NPO, a greater percentage of boys in the SI&NOE and dysfunctional NPO profiles than were girls. In addition, lower grades and younger adolescents tended to engage in the moderate NPO and SI&NOE profiles. The dysfunctional NPO reported higher levels of worry, depressive symptoms, anxiety, and stress, and worse sleep quality than the other profiles. The implications of these findings are discussed herein.