Miracle-dz/UniFAR-FTUs huggingface dataset:
Elastic electron scattering and rovibrational excitation of N2 at low incident energies

The scattering of low energy electrons from nitrogen has been investigated for a range of impact energies (1.5, 2.1, 3.0 and 5.0 eV) which encompass the 2 Pi g resonance. Measured differential and integral cross sections for both elastic scattering and rovibrational excitation (v=0-1, 2, 3) of the ground electronic state are compared with results from previous experimental and theoretical investigations. In some cases, particularly at 1.5 eV, significant discrepancies are found between the present and previous experiments.
View from the Biological Property: Insight into the Functional Diversity and Complexity of the Gut Mucus

Highlights What are the main findings? Mucus, as the most widely distributed biofilm and vital protective barrier on the surface of mucous membranes throughout the body, fulfills a number of critical activities in the maintenance of cellular and organismal homeostasis. Morphologic and biochemical evidence corroborate that the mucin family is composed of the transmembrane and gel-forming mucins, which have diverse functional modules. What is the implication of the main findings? Goblet cells are responsible for synthesis, storage, and secreting, which are implicated in either beneficial or detrimental factors. Excessive or insufficient mucus secretion as well as phenotypic alternation may be associated with gastrointestinal disorders, offering potential therapeutic targets for prevention in clinical practice. Abstract Due to mucin’s important protective effect on epithelial tissue, it has garnered extensive attention. The role played by mucus in the digestive tract is undeniable. On the one hand, mucus forms “biofilm” structures that insulate harmful substances from direct contact with epithelial cells. On the other hand, a variety of immune molecules in mucus play a crucial role in the immune regulation of the digestive tract. Due to the enormous number of microorganisms in the gut, the biological properties of mucus and its protective actions are more complicated. Numerous pieces of research have hinted that the aberrant expression of intestinal mucus is closely related to impaired intestinal function. Therefore, this purposeful review aims to provide the highlights of the biological characteristics and functional categorization of mucus synthesis and secretion. In addition, we highlight a variety of the regulatory factors for mucus. Most importantly, we also summarize some of the changes and possible molecular mechanisms of mucus during certain disease processes. All these are beneficial to clinical practice, diagnosis, and treatment and can provide some potential theoretical bases. Admittedly, there are still some deficiencies or contradictory results in the current research on mucus, but none of this diminishes the importance of mucus in protective impacts.
Impaired ketogenesis is associated with metabolic-associated fatty liver disease in subjects with type 2 diabetes

Aims The ketogenic pathway is an effective mechanism by which the liver disposes of fatty acids (FAs) to the peripheral tissues. Impaired ketogenesis is presumed to be related to the pathogenesis of metabolic-associated fatty liver disease (MAFLD), but the results of previous studies have been controversial. Therefore, we investigated the association between ketogenic capacity and MAFLD in subjects with type 2 diabetes (T2D). Methods A total of 435 subjects with newly diagnosed T2D was recruited for the study. They were classified into two groups based on median serum β-hydroxybutyrate (β-HB) level: intact vs. impaired ketogenesis groups. The associations of baseline serum β-HB and MAFLD indices of hepatic steatosis index, NAFLD liver fat score (NLFS), Framingham Steatosis index (FSI), Zhejian University index, and Chinese NAFLD score were investigated. Results Compared to the impaired ketogenesis group, the intact ketogenesis group showed better insulin sensitivity, lower serum triglyceride level, and higher low-density lipoprotein-cholesterol and glycated hemoglobin levels. Serum levels of liver enzymes were not different between the two groups. Of the hepatic steatosis indices, NLFS (0.8 vs. 0.9, p=0.045) and FSI (39.4 vs. 47.0: p=0.041) were significantly lower in the intact ketogenesis group. Moreover, intact ketogenesis was significantly associated with lower risk of MAFLD as calculated by FSI after adjusting for potential confounders (adjusted odds ratio 0.48, 95% confidence interval 0.25-0.91, p=0.025). Conclusions Our study suggests that intact ketogenesis might be associated with decreased risk of MAFLD in T2D.
Eastern Pacific Emitted Aerosol Cloud Experiment

Aerosol–cloud–radiation interactions are widely held to be the largest single source of uncertainty in climate model projections of future radiative forcing due to increasing anthropogenic emissions. The underlying causes of this uncertainty among modeled predictions of climate are the gaps in our fundamental understanding of cloud processes. There has been significant progress with both observations and models in addressing these important questions but quantifying them correctly is nontrivial, thus limiting our ability to represent them in global climate models. The Eastern Pacific Emitted Aerosol Cloud Experiment (E-PEACE) 2011 was a targeted aircraft campaign with embedded modeling studies, using the Center for Interdisciplinary Remotely-Piloted Aircraft Studies (CIRPAS) Twin Otter aircraft and the research vessel Point Sur in July and August 2011 off the central coast of California, with a full payload of instruments to measure particle and cloud number, mass, composition, and water uptake distributi.
Students from a Public School in the South of Chile with Better Physical Fitness Markers Have Higher Performance in Executive Functions Tests—Cross-Sectional Study

In the past few years, the level of physical fitness in children has decreased globally. According to the SIMCE test carried out in 2015, 45% of 8th year students in Chile were overweight. Moreover, international studies have shown that being overweight is associated with the development of chronic illnesses, negatively affecting cognitive mechanisms and processes. Nevertheless, there is little to no evidence that analyzes the relationship between physical fitness and executive functions in students, at a national level. The aim was to analyze the relationship between cardiorespiratory, musculoskeletal, and motor fitness, and performance in an executive functions test, in students from a public school in the south of Chile. A qualitative, descriptive –correlational, non-experimental, and cross-sectional approach was used. In total, 100 students between 9 and 12 and 11 months of age from a public school in the south of Chile completed the physical fitness assessments through the ALPHA fitness test, and 81 students completed the executive function assessments through the ENFEN test. It was evidenced that students who achieved a longer duration of time and a later stage in the Course Navette test, more centimeters in the standing broad jump (SBJ) test, and a shorter duration in the 4 × 10 shuttle run obtained a better score in the gray trail test. Additionally, students who presented a stronger dominant handgrip scored higher in the colored trail tests. We conclude that students who show a higher level of physical fitness also present a better development of executive functions such as working memory and inhibitory control. In addition, these results suggest physical condition is a factor to consider for better cognitive and school performance.
Some connections between clifford analysis and complex analysis

In the paper we construct kernels and mono-genic and holomorphic in in order to extend to several dimersions respectively the tranformation given by and the Fourier-Borel transformation T belonging to a space of analytic functionals. This leads toconnections between the theory of holomorphic functions of several variables and the theory of monogenic functions. These relationships are used to study the absolute convergence of the multiple Taylor series for monogenic functions.
1–2.5 $\mu$m spectra of jets from young stars: Strong $\ion{Fe}{ii}$ emission in HH111, HH240-241 and HH120

As part of a 1-2.5m spectroscopic survey of jets and molecular outflows, we present the spectra of three Herbig Haro chains (HH111, HH240/241, HH120) characterized by strong emission from several Feii transitions originating from the first 13 fine structure levels. Such emission is correlated with optical Sii emission and appears to decrease moving away from the driving source. From the analysis of the Feii lines we have derived electron densities values in the range 3 10 3 - 2 10 4 cm 3 , which are systematically larger than those inferred from optical Sii line ratios. We suggest that Feii lines, having critical densities higher than the optical Sii transitions, trace either regions of the post-shock cooling layers with higher compression, or a section of the jet axis at a higher degree of ionization. Strong H2 emission lines are also detected along the three flows and their analysis indicates that a combination of dierent shocks can be responsible for their excitation in the dierent objects. Consequently the Feii line emission, which requires the presence of fast dissociative shocks, is completely independent from the excitation mechanism giving rise to the molecular emission. In addition to the Feii and H2 lines, emission from other species such as Ci ,S ii ,N i as well as recombination lines from the Paschen series are detected and have been used as a reference to infer the gas-phase iron abundance in the observed HH objects. We estimate a grain destruction eciency of about 30-60%: the highest value is found for HH240A, which also shows the highest degree of excitation among the observed objects.
TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity

The transcription factor T cell factor-1 (TCF-1) is encoded by Tcf7 and plays a significant role in regulating immune responses to cancer and pathogens. TCF-1 plays a central role in CD4 T cell development; however, the biological function of TCF-1 on mature peripheral CD4 T cell-mediated alloimmunity is currently unknown. This report reveals that TCF-1 is critical for mature CD4 T cell stemness and their persistence functions. Our data show that mature CD4 T cells from TCF-1 cKO mice did not cause graft versus host disease (GvHD) during allogeneic CD4 T cell transplantation, and donor CD4 T cells did not cause GvHD damage to target organs. For the first time, we showed that TCF-1 regulates CD4 T cell stemness by regulating CD28 expression, which is required for CD4 stemness. Our data showed that TCF-1 regulates CD4 effector and central memory formation. For the first time, we provide evidence that TCF-1 differentially regulates key chemokine and cytokine receptors critical for CD4 T cell migration and inflammation during alloimmunity. Our transcriptomic data uncovered that TCF-1 regulates critical pathways during normal state and alloimmunity. Knowledge acquired from these discoveries will enable us to develop a target-specific approach for treating CD4 T cell-mediated diseases.
Prediction of cloud ice signatures in submillimetre emission spectra by means of ground‐based radar and in situ microphysical data

Submillimetre down‐looking radiometry is a promising technique for global measurements of cloud ice properties. There exist no observation data of sufficient size that can be used for detailed pre‐launch studies of such an instrument and other means must be found to obtain data to optimise the instrument design and similar tasks. Several aspects of the observations make traditional retrieval methods not suitable and nonlinear multidimensional regression techniques (e.g. Bayesian Monte Carlo integration and neural networks) must be applied. Such methods are based on a retrieval database and to be successful the database must mimic relevant real conditions closely. A method to generate such databases of high quality is described here. Correct vertical distributions of cloud ice are obtained by basic data from ground‐based radars. Cloud ice particle microphysical properties are generated randomly where statistical parameters are selected to mimic in situ measurement data closely. Atmospheric background fields from ECMWF are perturbed to account for variation on sub‐grid scales. All these data, together with sensor characteristics, are fed into a state‐of‐the‐art radiative transfer simulator (ARTS). The method was validated by a successful comparison with AMSU data. Copyright © 2007 Royal Meteorological Society
A novel mathematical model for the effects of wall properties on pumping flow of a biofluid in a symmetrical three-dimensional curved duct

Most pumping actions entail a physical volume change of the duct, which is frequently achieved by having a compliant wall or membrane. To the best of our knowledge, the current study is the first report on a mathematical model developed to analyze the peristaltic transport of a Newtonian fluid in a curved duct with rectangular face and compliant walls. Such geometries are most commonly used in clinical and biological equipment, where the walls of the duct need to be flexible. Flexible ducts are more useful than rigid ones because they do not require any extra modifications or accessories. Here, we have used the conditions of lubrication theory to construct an accurate model, and a common perturbation technique was incorporated to handle the Navier-Stokes equations with emphasis on various aspect ratios and curvatures. A system of curvilinear coordinates operating according to the principles of the cylindrical system was employed to represent the mathematical problem. No-slip boundary limitations were considered at the walls along with the extra constraint of compliant walls showing damping force and stiffness. Comprehensive graphical representations were made to illustrate the effects of all emerging factors of the study in both two- and three-dimensional formats. We found that large curvatures and flexure rigidity decreased the fluid velocity uniformly, but the aspect ratio and amplitude parameters could promote fluid velocity. Validation of the results was performed through the generation of a residual error curve. The current readings were taken again with a straight duct to make a comparison with the existing literature.
On the Dynamics of Two-Dimensional Hurricane-like Concentric Rings Vortex Formation

Abstract Despite the fact that asymmetries in hurricanes (e.g., spiral rainbands, polygonal eyewalls, and mesovortices) have long been observed in radar and satellite imagery, many aspects of their dynamics remain unsolved, particularly in the formation of the secondary eyewall. The underlying associated dynamical processes need to be better understood to advance the science of hurricane intensity forecasting. To fill this gap, a simple 2D barotropic “dry” model is used to simulate a hurricane-like concentric rings vortex. The empirical normal mode (ENM) technique, together with Eliassen–Palm (EP) flux calculations, are used to isolate wave modes from the model datasets to investigate their impact on the changes in the structure and intensity of the simulated hurricane-like vortex. From the ENM diagnostics, it is shown that asymmetric disturbances outside a strong vortex ring with a large vorticity skirt may relax to form concentric rings of enhanced vorticity that contain a secondary wind maximum. The fa.
Prevalence of Attention Deficit Hyperactivity Disorder and Sluggish Cognitive Tempo Symptoms in Children Presenting with Foreign Body Ingestion: A Case-Control Study

Foreign body ingestion (FBI) is one of the common causes of emergency admissions in infancy and childhood. Although the large majority of children who present with the FBI have no psychiatric diagnosis, present studies demonstrate that attention deficit hyperactivity disorder (ADHD) and related psychiatric problems might be a risk factor for FBI. This study aimed to compare the demographic variables and attention deficit hyperactivity disorder levels and sluggish cognitive tempo symptoms (ADHD-SCT) in children who ingested foreign bodies with healthy children. Also, we aimed to address the relationship between ADHD-SCT symptoms and the age of FBI. The FBI group comprised 44 children (age 2-8, median age: 5, 68.2% boys) admitted to the emergency, pediatric surgery, and pediatric gastroenterology department after FBI, and the healthy control group comprised 30 children (age 3-8, median age: 6, 56.7% boys). We administered the sociodemographic information form, SNAP-IV ADHD rating scale, and Barkley’s child SCT ratings scale to both groups of parents. Our results demonstrated that maternal education level was significantly lower in the FBI group, although other demographic characteristics of the samples were similar (p=0.023). In addition, ADHD-hyperactivity/impulsivity scores were significantly higher in the FBI group (p=0.01). Still, there were no significant differences in ADHD-inattention, SCT-daydreaming, and SCT-sluggishness scores (for all, p>0.05). We found positive-moderate relationships between SCT-daydreaming and sluggishness symptoms and FBI age (r=0.314, r=0.348, respectively). This means that higher SCT scores are related to an older FBI age. In conclusion, for the first time, we evaluated the ADHD and SCT symptoms in young children against FBI and found that ADHD-hyperactivity, but not ADHD-inattention symptoms, were significantly higher in the FBI group, and SCT symptoms increase the risk of FBI at an older age. In addition, we found that a lower maternal education level could be an additional risk factor for FBI. Despite the high hyperactivity in the FBI group, the low rate of child psychiatry evaluation should be considered when evaluating a child.
The miR-20a/miR-92b Profile Is Associated with Circulating γδ T-Cell Perturbations in Mild Psoriasis

Psoriasis vulgaris (PV) is an autoinflammatory dermatosis of unknown etiology. Current evidence suggests a pathogenic role of γδT cells, but the growing complexity of this population has made the offending subset difficult to pinpoint. The work on γδTCRint and γδTCRhi subsets, which express intermediate and high levels of γδTCR at their surface, respectively, is particularly scarce, leaving their inner workings in PV essentially unresolved. We have shown here that the γδTCRint/γδTCRhi cell composition and their transcriptom are related to the differential miRNA expression by performing a targeted miRNA and mRNA quantification (RT-qPCR) in multiplexed, flow-sorted γδ blood T cells from healthy controls (n = 14) and patients with PV (n = 13). A significant loss of miR-20a in bulk γδT cells (~fourfold decrease, PV vs. controls) largely mirrored increasing Vδ1-Vδ2- and γδintVδ1-Vδ2- cell densities in the bloodstream, culminating in a relative excess of γδintVδ1-Vδ2- cells for PV. Transcripts encoding DNA-binding factors (ZBTB16), cytokine receptors (IL18R1), and cell adhesion molecules (SELPLG) were depleted in the process, closely tracking miR-20a availability in bulk γδ T-cell RNA. Compared to controls, PV was also associated with enhanced miR-92b expression (~13-fold) in bulk γδT cells that lacked association with the γδT cell composition. The miR-29a and let-7c expressions remained unaltered in case–control comparisons. Overall, our data expand the current landscape of the peripheral γδT cell composition, underlining changes in its mRNA/miRNA transcriptional circuits that may inform PV pathogenesis.
Tumor Immune Microenvironment Heterogeneity at the Invasion Front and Tumor Center in Oral Squamous Cell Carcinoma as a Perspective of Managing This Cancer Entity

Background: Evaluating the tumor microenvironment and its influence on clinical management and therapy response is becoming increasingly important. However, only a few studies deal with the spatial distribution of immune cells within the tumor. This study aimed to describe the topology of immune cells in the microenvironment of oral squamous cell carcinoma (OSCC) sectioned by tumor invasion front and tumor center and to test their prognostic relevance regarding patient survival. Methods: A total of 55 OSCC patient specimens were collected retrospectively. The cancer tissue was immunohistochemically stained using an automated tissue stainer Ventana Benchmark Ultra (Roche) and analyzed using discrete expression marker profiles on immune cells. We investigated CD4+ lymphocytes, CD8+ lymphocytes, CD68+ macrophages, CD163+ macrophages, and M1 macrophages regarding their spatial distribution. Results: The statistical analysis revealed that the quantity and distribution of CD4+ (p = 0.007), CD8+ (p < 0.001), CD68+ (p < 0.001), CD163+ cells (p = 0.004), and M1 (p < 0.001) macrophages were significantly higher at the invasion front compared to the tumor center in all observed cases. However, high and low immune cell counts in the tumor center and invasion front were not associated with overall survival. Conclusion: Our results show two distinct immune microenvironments of the tumor center compared to the invasion front. Future studies are needed to explore how these results can be leveraged to improve patient therapy and outcome.
Retrospective screening of serum IgG glycosylation biomarker for primary Sjögren’s syndrome using lectin microarray

Background Primary Sjögren’s syndrome (PSS) is a systemic autoimmune disease resulting in significant loss of systemic gland secretory function. IgG glycosylation abnormalities had been found to play important roles in autoimmune diseases. Here, we aim to explore the specific changes of IgG glycosylation in PSS patient serum that could serve as potential biomarkers for disease diagnosis and differential diagnosis. Method From 2012 to 2018, patients diagnosed with PSS or primary biliary cholangitis (PBC) admitted consecutively to the department of Rheumatology at Peking Union Medical College Hospital were retrospectively included in this study. Glycan profiles of serum IgG from 40 PSS patients, 50 PBC patients, and 38 healthy controls were detected with lectin microarray containing 56 lectins. Lectins with significantly different signal intensity among groups were selected and validated by lectin blot assay. Results Lectin microarray analysis revealed that binding levels of Amaranthus Caudatus Lectin (ACL, prefers glycan Galβ3GalNAc, P = 0.011), Morniga M Lectin (MNA-M, prefers glycan mannose. P = 0.013), and Lens Culinaris Agglutinin (LCA, prefers glycan fucose) were significantly increased, while Salvia sclarea Agglutinin (SSA, prefers glycan sialylation, P = 0.001) was significantly decreased in PSS patients compared to PBC group. Compared to healthy controls, MNA-M (P = 0.001) and LCA (P = 0.028) were also significantly increased, while Phaseolus Vulgaris Erythroagglutinin and Phaseolus Vulgaris Leucoagglutinin (PHA-E and PHA-L, prefer glycan galactose, P = 0.004 and 0.006) were significantly decreased in PSS patients. The results of LCA and MNA-M were further confirmed using lectin blot assay. Conclusion Changes in serum IgG glycosylation in PSS increased binding levels of LCA and MNA-M lectins using microarray techniques compared to PBC patients and healthy controls, which could provide potential diagnostic value. Increased core fucose and mannose alteration of IgG may play important roles in PSS disease.