Miracle-dz/UniFAR-FTUs huggingface dataset:
Maternal Intake Restriction Programs the PKA-CREB Pathway to Regulate Energy Metabolism, CLOCK and mTOR Signals in the Skeletal Muscles of Goat Offspring

BackgroundThe biological mechanism about that maternal undernutrition increases the metabolic disorder risk of skeletal muscles in offspring is less known. We hypothesize that maternal intake restriction influences metabolic signals in the skeletal muscles of offspring via a glucagon-mediated pathway. Twenty-four pregnant goats were assigned to the control (100% of the nutrients requirement) and restricted (60% of the control from pregnant days of 45 to 100) groups. Blood and longissimus thoracis muscle were sampled from dams, fetuses and kids in each group.ResultsIntake restriction reduced the total blood protein of dams and fetuses. Maternal restriction decreased the CREB1, CREBBP, PKA, BMAL1, AKT1, mTOR, and RPTOR mRNA expressions in the fetuses, reduced the CREBBP, NR1H3, DBP and PKA mRNA levels in the kids, but increased the PGC1α and TSC2 mRNA levels in the fetuses, while the mRNA expression of CLOCK and TSC2 genes was increased in the restricted kids. The protein expression of total PKA and phosphorylated PKA of the restricted fetuses and kids were downregulated, while the protein expression of total mTOR and phosphorylated mTOR were reduced in the restricted fetuses and kids. ConclusionsMaternal intake restriction regulated fat oxidation, protein synthesis, and circadian clock expression in the muscles of the offspring via the glucagon-mediated PKA-CREB pathway, which reveals a molecular pathway that maternal undernutrition leads to metabolic adaptation of skeletal muscle in offspring.
Oldest Dryas hydroclimate reorganization in the eastern Iberian Peninsula after the iceberg discharges of Heinrich Event 1

Abstract This study examines the first precisely dated and temporally highly resolved speleothem record from Iberia that reconstructs the Oldest Dryas (OD). The onset of cold conditions in the study area, contemporary with the beginning of Heinrich Stadial 1, is recorded at 18.13 ± 0.08 ka, with a pronounced drop of 6.1‰ in δ13C in 250 years. Henceforth, stadial conditions depict a period of instability in the Atlantic Meridional Overturning Circulation, peaking in freshwater input from iceberg melting during Heinrich Event 1. Anomalies in the δ18O of the stalagmite attributed to such a freshwater event are found from 16.17 to 15.89 ka. Such absolute dates given to the onset of the OD in Iberia and to the main iceberg discharges are reliable anchor points for non-absolute chronologies. Two periods are identified in the OD: OD-a (18.13–16.17 ka) is characterized by wet conditions and a faster growth rate, and OD-b (15.89–14.81 ka) exhibits relative dryness and a slower growth rate. The sudden release of fresh water is considered to be the reason for the disruption of rainfall patterns in eastern Iberia. The present study also highlights the existence of heterogeneous and complex hydrological conditions during the OD in Iberia when both Atlantic and Mediterranean realms are considered.
On the Mechanism of the Dissolution of Quartz and Silica in Aqueous Solutions

Quartz and silica are common materials, and their dissolution is of significant interest to a wide range of scientists. The kinetics of the dissolution of quartz and silica have been measured extensively, yet no clear theory of dissolution is available. A novel theory of dissolution and crystallization has recently been proposed that envisages the removal of material from the surface to form ions in solution leaving behind a charged surface vacancy. These vacancies create a potential difference across the Stern layer that accelerates or retards the removal of ions. In this way, the surface potential difference is caused by and influences the rate of the removal of ions. From this theory, a model of quartz dissolution is derived that predicts the observed orders of reaction. This prediction of the orders of reaction fits a data set consisting of 285 experiments. The model also describes the effect of Na+, K+, and Li+ ions, as well as the effect of heavy water. A significant component of the model is its ability to describe the zeta potential of the quartz–water interface. The model successfully predicts a transient period at the beginning of the reaction when the rate could either increase or decrease.
FAKTOR YANG BERPENGARUH TERHADAP KEPATUHAN MASYARAKAT PADA PROTOKOL KESEHATAN DALAM MENCEGAH PENYEBARAN COVID-19

The Covid-19 pandemic is one of the events threatening all around the world particularly in health sector. The widespread of this virus causes the most crucial issue to stop it immediately. Various kinds of policies have been made by the government to end the spread. However, on the other hand, the community is critically required to comply with health protocols as a serious effort to stop it. This study aims to analyze the level of community compliance in implementing health protocols in their daily lives, as well as to determine the socio-demographic factors that affect compliance with health protocols in society in Indonesia. The data used in this study is derived from the 2020 Social Demographic Impact of Covid-19 Survey from BPS. This analysis uses descriptive and regression analysis. The empirical results show that the average adherence index of male respondents is lower than that of female respondents, and there is a tendency that young people are more disobeying about health protocols with a relatively lower average adherence score compared to the older people. In addition, the socio-demographic characteristics that affect the level of community compliance with health protocols are respondent reaction status, perceptions of the effectiveness of independent isolation, level of concern about Covid-19 news, level of concern about traveling outside the home, gender, education level, marital status, health status, and age.
Effects of process parameters on the physicochemical properties of corn stalk hydrochar and the removal of alkali and alkaline earth metals

Funding information the General Programs of the National Natural Science Foundation of China, Grant/Award Number: 51676058; the Science and Technology fund of Liaoning Province Education Department, Grant/Award Number: LQN201705 Abstract The advantages of the direct combustion of agricultural biomass for power generation are restricted due to the drawbacks of this biomass and the deep peak shaving trend. Hydrothermal carbonization can improve the physical and thermochemical properties of raw materials. Corn stalk samples were selected as the research object in this study. Corn stalk hydrochars were prepared with reaction pressures of 0–3 MPa, reaction temperatures of 160–240 C, and residence times of 1–10 h. The effects of the process parameters on the physicochemical properties of hydrochar and on the removal of alkali and alkaline earth metals (AAEMs) were studied by measuring the hydrochar mass, energy yield, product composition, morphology, as well as the removal efficiency of AAEMs. The results indicated that the corn stalk hydrochar had higher mass and energy yields than the raw corn stalk. X-ray diffraction showed that the carbon content in the hydrochar was greater than that in raw corn stalk. Scanning electron microscopy showed that the reaction temperature played a more significant role in the hydrothermal carbonization process than the reaction pressure and residence time.
Prostatic Adenocarcinoma presenting as Large Cystic lesion of Prostate - A Case Report

73 years old male presented with acute urinary retention. There was no history of lower urinary tract symptoms (LUTS) prior to this episode. On digital rectal examination he had a large nontender cystic swelling on anterior wall of rectum. His serum PSA was 62.36 ng/ml. After Imaging & fine-needle aspiration cytology (FNAC) he was diagnosed as a case of benign cyst likely prostatic utricle cyst. He was given a trial without catheter which failed, and He was managed with robot assisted laparoscopic excision of prostatic cyst. Histopathological examination of excised specimen revealed presence of Prostate Adenocarcinoma arising within cystic lesion.
Examining the determinants of renewable energy deployment: Does the choice of indicator matter?

Comprehending the determinants of renewable energy (RE) deployment has preoccupied the energy literature as well as policymakers internationally due to countries' overall shift away from fossil fuels in the energy mix. As stated in the literature, empirical studies that analyze the determinants of RE deployment use a number of different indicators for RE. The effect of an ambiguous choice of the proxy might produce various outcomes and thus create inconsistencies in the policy recommendations. This study aims at filling this gap in the literature comparing and contrasting not only the use of RE indicators but also, for robustness purposes, using indicators at aggregate and per capita forms for a global sample, developed countries, and developing countries. For the empirical purpose, this study employs two econometric techniques: the pooled ordinary least squares with robust SEs and the augmented mean group estimator, which account for cross‐sectional dependence in the dataset. The results show that a 1% increase in gross domestic product (GDP) or GDP per capita leads to an increase in RE between 0.05% and 1.01% and a 1% increase in energy price causes an increase in RE between 0.07% and 0.99% with respect to various proxies, implying that the magnitudes of impacts of income and oil price are quite smaller when RE is proxied with RE consumption than when it is proxied with RE production. In addition, their impacts dramatically change across the choice between the share of RE and the levels of RE. More interestingly, not only the size of the effect of carbon emissions but also its direction changes across indicators. Overall, the choice of RE indicator is of great importance in putting forward reliable and consistent policy suggestions.
Sustainable Application of ZIF-8 for Heavy-Metal Removal in Aqueous Solutions

Water is life, and clean-water demand is increasing daily as a result of rapid population growth and industrial evolution. Nevertheless, due to the inadequate supply and availability of new water sources, there is a need for effective, sustainable removal of contaminants for wastewater reuse. Several treatment approaches that include chemical, physical, and biological methods have been thoroughly tested, with biological treatment being regarded as the most cost-effective and environmentally friendly method. However, the presence of heavy metals and complicated chemicals that are nonbiodegradable limits the use of this cost-effective approach. In this paper, we review the sustainable application of a cheap, water-stable metal-organic framework, the zeolitic imidazolate framework (ZIF-8), with an easier synthesis approach for heavy-metal removal in aqueous solutions. In this review, we discuss the removal efficiency in terms of adsorption capacity, describe the underlying mechanism behind the adsorption capacity of ZIF-8, present a sustainable synthesis approach, and make vital suggestions to aid in the future application of ZIF-8 for the removal of heavy metals.
Applying the UTAUT2 Model to a Non-Technological Service: The Case of Spa Tourism

Well-being tourism is a $639 billion market. Spa tourism is considered the most important segment within this market. The present study uses the Unified Theory of Acceptance and Use of Technology (UTAUT2) model to analyse tourists’ purchase intentions regarding a thermal suite. The model was originally designed to analyse users’ acceptance of new technologies. The original contribution of this paper is to apply it to a non-technological service. Specifically, data were collected through a questionnaire administered to a sample of 810 potential Spanish spa-goers. A consistent partial least squares (PLSc) SEM technique was used. The proposed model explains 53.3% of the variance in Purchase Intentions regarding the thermal suite. Performance expectancy is the variable that plays the greatest role in tourists’ purchase intentions, followed by hedonic motivation.
Assessment of Cloud Computing Success Factors for Sustainable Construction Industry: The Case of Nigeria

Cloud Computing has become a valuable platform for sustainability in many countries. This study evaluates the cloud computing implementation and its Critical Success Factors (CSFs) towards ensuring sustainable construction projects in Nigeria. Data were collected from previous literature, supplemented by a quantitative approach via a questionnaire survey. Data were collected from 104 construction professionals while cloud computing CSFs were examined using Relative Importance Ranking (RII) and Exploratory Factor Analysis (EFA). The results show that cloud computing’s awareness level is 96.2%, which means that the respondents are aware of cloud computing concept. Furthermore, the result shows that most of the respondents are adopting the concept. The analysis of the CSFs indicated that reliable data storage, performance as well as cost of accessibility and availability were the four most significant CSFs to cloud computing applications. Analysis of the CSFs through EFA generated four main components which include human satisfaction, organization, client’s acceptance, and industry-based. Consequently, this study contributed to existing body of knowledge by highlighting the cloud computing CSFs for achieving sustainable construction project. As such, the results could be a game-changer in the construction industry—not only in Nigeria but also in developing nations where construction projects are implemented through similar style and procedure. This study would be a benchmark for supporting decision-makers to improve data fragmentation, in which the use of data is paramount to the execution of construction works. Finally, the results of this study would be useful for enhancing sustainability and general management of construction projects through cloud computing implementation.
Board reforms and audit fees: international evidence

ABSTRACT With a difference-in-differences approach, we find that world-wide reforms result in higher audit fees for reform firms. And this is specially so for reforms involving components of director independence and/or audit committee and auditor independence, adopting the rule-based approach, and implemented in countries with weaker institutional quality. Further analysis reveals that the increase in audit fees is driven by the increase in auditors’ efforts and auditees’ litigation risk, while the improved financial reporting quality has a negative effect on audit fees. Overall, our study examines one compliance cost, as well as its variations, of the board reforms.
Genotypic selection of multispecific hybrids obtained through crosses between commercial Passiflora edulis and wild passiflora species

Abstract The interspecific introgression of resistance genes to diseases in commercial varieties through interspecific crosses has been adopted as a strategy in breeding programs of sour passion fruit. This work aimed to evaluate 11 progenies of multispecific hybrids obtained from crosses involving seven Passiflora species, in addition to four commercial cultivars, using the REML/BLUP method. The experiment was carried out as a randomized block design with six repetitions and three plants per plot. Ten fruit traits were evaluated. The additive, multiplicative, and sum of ranks indexes were applied to determine the most appropriate selective strategy in the simultaneous increase of fruit weight, number of fruits, and yield. Plants from the 325 x VAO progeny showed a lower bacterial defoliation index and better means predicted for the traits number of fruits and productivity. The progenies 325 x LD4, PL3 x LD4, and the controls CSB-Marília and BRS-Gigante Amarelo showed plants with better-predicted means for traits related to fruit quality. The genetic gains demonstrated good prospects for the use of wild species in sour passion fruit genetic breeding.
Ṣukūk on blockchain: a legal, regulatory and Sharī’ah review

Purpose This paper aims to explore issues arising from ṣukūk (Islamic bonds) on blockchain, including Sharīʾah (Islamic law) and legal matters. Design/methodology/approach A qualitative methodology is used in conducting this research where relevant literature on ṣukūk was reviewed. Through a doctrinal approach, the paper presents analyses on the practice of ṣukūk and ṣukūk on blockchain by discussing its legal, Sharīʾah and regulatory issues. This culminates in a conceptual analysis of blockchain ṣukūk and its peculiar challenges. Findings This paper reveals that digitizing ṣukūk issuance through blockchain remedies certain inefficiencies associated with ṣukūk transactions. Indeed, structuring ṣukūk on a blockchain platform can increase transparency of underlying ṣukūk assets and cash flows in addition to reducing costs and the number of intermediaries in ṣukūk transactions. The paper likewise brings to light legal, regulatory, Sharīʾah and cyber risks associated with ṣukūk on blockchain that confront investors, practitioners and regulators. This calls for deeper collaboration in research among Sharīʾah scholars, lawyers, regulators and information technology experts. Research limitations/implications As a pioneering subject, the paper notes the prospects of blockchain ṣukūk and the current dearth of literature on it. The paper would assist relevant Islamic capital market entities and authorities to determine the potential and impact of blockchain ṣukūk in their respective businesses and the financial system. Practical implications Blockchain ṣukūk will assist in addressing issues inherent in classical ṣukūk and in paving the way to innovative solutions that will facilitate and enhance the quality of ṣukūk transactions. For that, ṣukūk would require appropriate regulatory technology to address its governance and regulation peculiarities. Originality/value Integrating ṣukūk with blockchain technology will add value to it. The paper advances the idea that blockchain ṣukūk revolutionises ṣukūk and enhances its practice against known inadequacies.
Perception and Acceptance of Pre-Marital Fertility Screening among Final Year Students of College of Health Sciences at a University in North Central, Nigeria

Premarital screening is a worldwide activity that aims to diagnose and treat unrecognized disorders and reduce the transmission of diseases to couples and children. This study was aimed at assessing the perception and acceptance of premarital fertility screening among final year students of the college of health sciences, University of Ilorin, Kwara state.
An Innovative Successive Approximation Register Analog-to-Digital Converter for a Nine-Axis Sensing System

With nine-axis sensing systems in 5G smartphones, mobile power consumption has become increasingly important, and ultra-low-power (ULP) sensor circuits can decrease power consumption to tens of microwatts. This paper presents an innovative successive approximation register analog-to-digital converter, which comprises fine (three most significant bits (MSBs) plus course conversion (11 least significant bits (LSBs)) capacitive digital-to-analog converters (CDACs), ULP, four-mode reconfigurable resolution (9, 10, 11, or 12 bits), an internally generated clock, meta-detection, the switching base midpoint voltage (Vm) (SW-B-M), bit control logic, multi-phase control logic, fine (three MSBs) plus course conversion (11 LSBs) switch control logic, phase control logic, and an input signal plus negative voltage (VI + NEG) voltage generator. Then, the mechanism of the discrete Fourier transform (DFT)-based calibration is applied. The scalable voltage technique was used, and the analog/digital voltage was Vanalog (1.5 V) and Vdigital (0.9 V) to meet the specifications of the nine-axis ULP sensing system. The CDACs can reconfigure four-mode resolutions, 9–12 bits, for use in nine-axis sensor applications. The corresponding dynamic signal-to-noise and distortion ratio performance was 50.78, 58.53, 62.42, and 66.51 dB. In the 12-bit mode, the power consumption of the ADC was approximately 2.7 μW, and the corresponding figure of merit (FoM) was approximately 30.5 fJ for each conversion step.
Recent trends and review on
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Department of Electrical Engineering, Aligarh Muslim University, Aligarh, Uttar Pradesh, India Department of Electrical Engineering, Qatar University, Doha, Qatar Power Electronics and Renewable Energy Research Laboratory, Department of Electrical Engineering, University of Malaya, Kuala Lumpur, Malaysia School of Software and Electrical Engineering, Swinburne University of Technology, Melbourne, Victoria, Australia
Residential Mobility and Trust: The Moderating Role of Cognitive Need for Closure

This study examined the link between residential mobility and interpersonal trust building. Study 1 revealed a negative association between residential mobility and trust by measuring personal residential-mobility history. Study 2 demonstrated that participants who were momentarily primed with mobility showed a lower investment than participants in the control group in a trust game. The results of Study 3 showed that need for closure moderated the link between residential mobility and trust-building intention. Specifically, lower need-for-closure people had a significantly lower trust tendency in the mobility group than in the stable group. These findings illuminate the underlying influence of need for closure in the link between residential mobility and trust.
FAST ESTIMATE OF PLANE WAVE ATTENUATION OF CONDUCTIVE POWDERS FOR RAPID DEPLOYMENT OF CUSTOMIZED CEMENT BASED MICROWAVE ABSORBING SOLUTIONS

Enhancing the electromagnetic absorption properties of pozzolanic cement provides scope for low cost realisation of frequency screened buildings. Electromagnetic wave attenuation attribute of conductive filler inclusions determines the absorption properties of filler loaded cement mortar. A transmission line based rapid measurement technique for the speedy estimate of microwave attenuation of conductive fillers is presented, providing quick approximates of cement mortar thickness for realizing customized absorption loss. Ash from three units of steel plant including EAF, AoD, and ARS units is investigated. Coaxial transmission line supports TEM propagation, hence is well suited for estimating plane wave characteristics. Ash filled coaxial transmission structures are subjected to scattering matrix measurements in the frequency range 800 MHz–4 GHz. Plane wave attenuation is estimated from the scattering matrix transfer coefficient (S21). Ashes guarantee minimum 10 dB/m attenuation in the specified frequency range with ash from ARS unit providing loss over 50 dB/m. The database of customized cement mortar (composite) thickness for realizing varied absorption losses, incorporating ARS ash, is projected. The presented technique reduces the requirement of anechoic chambers, broad band horns, and liability of prototyping large mortar samples (all frequency dependent), for estimating shielding properties of conductive filler loaded cement mortar composites, over wide band. Cement panels with customized absorption loss provide scope as low cost solution for managing device colocation issues encountered in evaluating EMI/EMC concerns is future IoT based systems.