Miracle-dz/UniFAR-FTUs huggingface dataset:
PHYSICAL PROPERTIES OF THE INNER SHOCKS IN HOT, TILTED BLACK HOLE ACCRETION FLOWS

Simulations of hot, pressure-supported, tilted black hole accretion flows, in which the angular momentum of the flow is misaligned with the black hole spin axis, can exhibit two nonaxisymmetric shock structures in the inner regions of the flow. We analyze the strength and significance of these shock structures in simulations with tilt angles of 10° and 15°. By integrating fluid trajectories in the simulations through the shocks and tracking the variations of fluid quantities along these trajectories, we show that these shocks are strong, with substantial compression ratios, in contrast to earlier claims. However, they are only moderately relativistic. We also show that the two density enhancements resembling flow streams in their shape are in fact merely post-shock compressions, as fluid trajectories cut across, rather than flow along, them. The dissipation associated with the shocks is a substantial fraction (≃ 3%–12%) of the rest mass energy advected into the hole, and therefore comparable to the dissipation expected from turbulence. The shocks should therefore make order unity changes in the observed properties of black hole accretion flows that are tilted.
Effects of age and sex on outcomes of the Q-Motor speeded finger tapping and grasping and lifting tests-findings from the population-based BiDirect Study

Background Q-Motor is a suite of motor tests originally designed to assess motor symptoms in Huntington's disease. Among others, Q-Motor encompasses a finger tapping task and a grasping and lifting task. To date, there are no systematic investigations regarding effects of variables which may affect the performance in specific Q-Motor tests per se, and normative Q-Motor data based on a large population-based sample are not yet available. Objective We investigated effects of age and sex on five selected Q-Motor outcomes representing the two core Q-Motor tasks speeded finger tapping and grasping and lifting in a community sample of middle-aged to elderly adults. Furthermore, we explored effects of the potentially mediating variables educational attainment, alcohol consumption, smoking status, and depressive symptoms. Moreover, we explored inter-examiner variability. Finally, we compared the findings to findings for the Purdue Pegboard test. Methods Based on a sample of 726 community-dwelling adults and using multiple (Gaussian) regression analysis, we modeled the motor outcomes using age, sex, years in full-time education, depressive symptoms in the past seven days, alcohol consumption in the past seven days, and smoking status as explanatory variables. Results With regard to the Q-Motor tests, we found that more advanced age was associated with reduced tapping speed, male sex was associated with increased tapping speed and less irregularity, female sex was associated with less involuntary movement, more years of education were associated with increased tapping speed and less involuntary movement, never smoking was associated with less involuntary movement compared to current smoking, and more alcohol consumed was associated with more involuntary movement. Conclusion The present results show specific effects of age and sex on Q-Motor finger tapping and grasping and lifting performance. In addition, besides effects of education, there also were specific effects of smoking status and alcohol consumption. Importantly, the present study provides normative Q-Motor data based on a large population-based sample. Overall, the results are in favor of the feasibility and validity of Q-Motor finger tapping and grasping and lifting for large observational studies. Due to their low task-complexity and lack of placebo effects, Q-Motor tests may generate additional value in particular with regard to clinical conditions such as Huntington's or Parkinson's disease.
Thermodynamic and thermoelectric properties of (Ga,Mn)As and related compounds

Various experimental results providing information on thermodynamic density of states in (Ga,Mn)As are analyzed theoretically assuming that holes occupy GaAs-like valence bands. Allowing for Gaussian fluctuations of magnetization, the employed model describes correctly a critical behavior of magnetic specific heat found experimentally in (Ga,Mn)As near the Curie temperature T_C [S. Yuldashev et al., Appl. Phys. Express 3, 073005 (2010)]. The magnitudes of room temperature thermoelectric power, as measured for GaAs:Be and (Ga,Mn)As [M. A. Mayer et al., Phys. Rev. B 81, 045205 (2010)], are consistent with the model for the expected energy dependencies of the hole mobility. The same approach describes also temperature variations of conductance specific to the Anderson-Mott localization, found for various dimensionality (Ga,Mn)As nanostructures at subkelvin temperatures [D. Neumaier et al., Phys. Rev. Lett. 103, 087203 (2009)]. We conclude that the examined phenomena do not provide evidence for an enhancement of density of states by the presence of an impurity band at the Fermi energy in ferromagnetic (Ga,Mn)As. Furthermore, we provide for (Ga,Mn)As expected values of both electronic specific heat at low temperatures T << T_C and magnetization as a function of the magnetic field at T_C.
Is depression the contraindication of anterior cervical decompression and fusion for cervical spondylosis?

Objective To evaluate whether depression is the contraindication of anterior cervical decompression and fusion (ACDF) for cervical spondylosis. Material and methods Patients with single-segment cervical spondylosis who underwent ACDF from January 2015 to December 2018 in our department were retrospectively included in this study and divided into two groups. Patients who were diagnosed of depression and prescribed with antidepressant drugs for at least 6 months before surgery were included in the intervention group. Patients without depression were included in the control group. The Beck Depression Inventory (BDI) score was used to evaluate the severity of depression. Visual Analogue Scale (VAS) score, Japanese Orthopeadic Association (JOA) score, Neck Disability Index (NDI), and the 36-Item Short-Form Health Survey (SF-36) were recorded as indexes to assess the pain, cervical spine function, degree of cervical spine injury, and life quality, respectively. The operative time, operative blood loss, hospital stay and complications were also recorded and compared. Results A total of 117 patients were included in this study, involving 32 patients in the intervention group and 85 patients in the control group. No significant differences were found in operative time, operative blood loss, hospital stay and complications between the two groups (P>0.05). The BDI score, VAS score, JOA score, NDI, SF-36 physical component score (SF-36 PCS) and SF-36 mental component score (SF-36 MCS) were all significantly improved at last follow-up in both the two groups. The intervention group showed higher BDI score and SF-36 MCS than the control group at both preoperative and the last follow-up (P<0.05), and the improvements of BDI score and SF-36 MCS were also higher in the intervention group (P<0.05). Although the intervention group showed higher VAS score, NDI, SF-36 PCS and lower JOA score at preoperative and last follow-up, respectively (P<0.05), there were no significant differences in the improvements of these indexes between the two group (P>0.05). Conclusions Depression is not the contraindication of ACDF for cervical spondylosis. Depression patients who received preoperative antidepressants can achieve similar improvement of clinical symptoms from ACDF with non-depression patients.
Trait mindful awareness predicts inter-brain coupling but not individual brain responses during naturalistic face-to-face interactions

In recent years, the possible benefits of mindfulness meditation have sparked much public and academic interest. Mindfulness emphasizes cultivating awareness of our immediate experience and has been associated with compassion, empathy, and various other prosocial traits. However, neurobiological evidence pertaining to the prosocial benefits of mindfulness in social settings is sparse. In this study, we investigate neural correlates of trait mindful awareness during naturalistic dyadic interactions, using both intra-brain and inter-brain measures. We used the Muse headset, a portable electroencephalogram (EEG) device often used to support mindfulness meditation, to record brain activity from dyads as they engaged in naturalistic face-to-face interactions in a museum setting. While we did not replicate prior laboratory-based findings linking trait mindfulness to individual brain responses (N = 379 individuals), self-reported mindful awareness did predict dyadic inter-brain synchrony, in theta (~5–8 Hz) and beta frequencies (~26-27 Hz; N = 62 dyads). These findings underscore the importance of conducting social neuroscience research in ecological settings to enrich our understanding of how (multi-brain) neural correlates of social traits such as mindful awareness manifest during social interaction, while raising critical practical considerations regarding the viability of commercially available EEG systems.
Digital health and modern technologies applied in patients with heart failure: Can we support patients’ psychosocial well-being?

Despite advances in the treatment of heart failure (HF), the physical symptoms and stress of the disease continue to negatively impact patients’ health outcomes. Technology now offers promising ways to integrate personalized support from health care professionals via a variety of platforms. Digital health technology solutions using mobile devices or those that allow remote patient monitoring are potentially more cost effective and may replace in-person interaction. Notably, digital health methods may not only improve clinical outcomes but may also improve the psycho-social status of HF patients. Using digital health to address biopsychosocial variables, including elements of the person and their context is valuable when considering chronic illness and HF in particular, given the multiple, cross-level factors affecting chronic illness clinical management needed for HF self-care.
Hydraulic constraints determine the distribution of heteromorphic leaves along plant vertical height

As an interesting and important trait of some drought-tolerant species, heteromorphic leaves are distributed differentially along plant vertical heights. However, the underpinning mechanism for the formation of heteromorphic leaves remains unclear. We hypothesize that heteromorphic leaves are caused by the hydraulic constraints possibly due to the compensation of the changes in functional traits in response to water transport capacity or the reduction of ineffective water loss. In this study, differences in water transport capacity, morphological traits, anatomical structures, and cellular water relations among three typical types of heteromorphic leaves (i.e., lanceolate, ovate, and broad-ovate) of Populus euphratica Oliv. (a dominant species of desert riparian forest in Central and West Asia) and their relationships were analyzed in order to explore the forming mechanism of heteromorphic leaves. The results showed that the lanceolate, ovate, and broad-ovate leaves were growing in the lower, intermediate, and higher positions from the ground, respectively. Morphological traits, anatomical structures, cellular water relations, and water transport capacity significantly varied among the three types of heteromorphic leaves (P< 0.01). Drought stress in broad-ovate leaves was significantly higher than that in ovate and lanceolate leaves (P< 0.01). Water transport capacity has significant correlations with morphological traits, anatomical structures, and cellular water relations (R 2 ≥ 0.30; P< 0.01). Our results indicated that heteromorphic leaves were used as an important adaptive strategy for P. euphratica to alleviate the increase of hydraulic constraints along vertical heights.
THE DENSE GAS MASS FRACTION OF MOLECULAR CLOUDS IN THE MILKY WAY

The mass fraction of dense gas within giant molecular clouds (GMCs) of the Milky Way is investigated using 13CO data from the Five College Radio Astronomy Observatory Galactic Plane Surveys and the Bolocam Galactic Plane Survey (BGPS) of 1.1 mm dust continuum emission. A sample of 860 compact dust sources are selected from the BGPS catalog and kinematically linked to 344 clouds of extended (>3′) 13CO J = 1–0 emission. Gas masses are tabulated for the full dust source and subregions within the dust sources with mass surface densities greater than 200 M☉ pc−2, which are assumed to be regions of enhanced volume density. Masses of the parent GMCs are calculated assuming optically thin 13CO J = 1–0 emission and local thermodynamic equilibrium conditions. The mean fractional mass of dust sources to host GMC mass is . The high column density subregions comprise of the mass of the cloud. Owing to our assumptions, these values are upper limits to the true mass fractions. The fractional mass of dense gas is independent of GMC mass and gas surface density. The low dense gas mass fraction suggests that the formation of dense structures within GMCs is the primary bottleneck for star formation. The distribution of velocity differences between the dense gas and the low density material along the line of sight is also examined. We find a strong, centrally peaked distribution centered on zero velocity displacement. This distribution of velocity differences is modeled with radially converging flows toward the dense gas position that are randomly oriented with respect to the observed line of sight. These models constrain the infall velocities to be 2–4 km s−1 for various flow configurations.
Imitating the effects of drilling fluid invasion on the strength behaviors of hydrate-bearing sediments: An experimental study

The drilling fluid invasion into hydrate-bearing sediments will change the geomechanical properties of the reservoir and may lead to uncontrolled geological disasters in the worst case. Native sediments are replaced with artificial samples in this study to investigate the effect of drilling fluid invasion on the strength behaviors of hydrate-bearing sediments. The triaxial test is used primarily to assess the strength behaviors of hydrate-bearing sediments at varying temperatures, pressures, and hydrate saturation levels. The process of water-based drilling fluid penetrating into hydrate-bearing sediments is then experimentally imitated under various experimental conditions, with reservoir temperature of 4°C and pore pressure of 10 MPa. The possible repercussions of drilling fluid invasion and hydrate phase transition are identified by testing the mechanical properties of sediments under various invasion times and temperatures. The findings reveal that when hydrate saturation rises from 5% to 35%, the gas hydrate sediments shift from strain hardening to strain softening, with the critical hydrate saturation value of transition is between 15% and 25%. Peak strength increases with increasing hydrate saturation and pressure, and decreases with increasing temperature, whether drilling fluid invasion is present or not. The peak strength, Young’s modulus, shear modulus, and secant modulus of hydrate sediments all decreased significantly after drilling fluid invasion, although the Poisson’s ratio rose. These mechanical parameters are related to temperature and pressure under the action of drilling fluid. Finally, engineering and research recommendations for reducing the risk of drilling fluid invasion and hydrate dissociation are made based on experimental findings and theoretical analysis. This study innovatively examine the geomechanical mechanical properties of drilling fluid invading hydrate reservoir, which is critical for avoiding production concerns.
ISW–LSS CROSS-CORRELATION IN COUPLED DARK ENERGY MODELS WITH MASSIVE NEUTRINOS

We provide an exhaustive analysis of the Integrated Sachs–Wolfe (ISW) effect in the context of coupled dark energy cosmologies where a component of massive neutrinos is also present. We focus on the effects of both the coupling between dark matter and dark energy and of the neutrino mass on the cross-correlation between galaxy/quasar distributions and ISW effect. We provide a simple expression to appropriately rescale the galaxy bias when comparing different cosmologies. Theoretical predictions of the cross-correlation function are then compared with observational data. We find that, while it is not possible to distinguish among the models at low redshifts, discrepancies between coupled models and ΛCDM increase with z. In spite of this, current data alone does not seem able to distinguish between coupled models and ΛCDM. However, we show that upcoming galaxy surveys will permit tomographic analysis that will allow us to better discriminate among the models. We discuss the effects on cross-correlation measurements of ignoring galaxy bias evolution, b(z), and magnification bias correction and provide fitting formulae for b(z) for the cosmologies considered. We compare three different tomographic schemes and investigate how the expected signal-to-noise ratio, S/N, of the ISW–LSS cross-correlation changes when increasing the number of tomographic bins. The dependence of S/N on the area of the survey and the survey shot noise is also discussed.
The impact of changes in taste, smell, and eating behavior in children with cancer undergoing chemotherapy: A qualitative study

Background and aims Taste changes are the third most common bothersome symptom during treatment in children with cancer. However, it is still unclear what the essence of these taste changes are, to what degree concomitant changes in sense of smell qualify this bothersome treatment symptom and how much of an impact these changes have on the life of children with cancer. The aim of this study was to explore characteristics of both taste and smell changes and to gain insight into the impact of these changes in children with cancer receiving chemotherapy. Methods Semi-structured interviews were performed until data saturation was achieved in each age group (6–12, 13–17 years). This resulted in an in-depth description of taste and smell changes, including its impact on the life of 27 children with various cancer types receiving chemotherapy. Thematic analysis of interview data was performed. Results Interview data could be grouped into three main themes, namely changes in (1) taste, (2) smell, and (3) eating behavior. As expected, most children reported experiencing taste and smell changes just after start of treatment, but changes varied greatly between children; that is, some reported changes in intensity (increased or decreased), whereas others reported different perceptions or preferences (from sweet to savory). Taste and smell changes (regardless of direction) negatively impacted quality of life, with these changes commonly described as “disappointing” or “frustrating. ” Interestingly, particular chemotherapeutic agents were frequently mentioned regarding taste and smell changes, prompting sensory-specific coping strategies. Children's eating behavior changed in terms of alterations in food liking and appetite, sometimes due to chemosensory changes, but children also mentioned specific medication or hospital food being responsible for their altered eating behavior. Conclusions Both taste and smell changes are common in children with cancer. The essence of these changes varies widely, but taste and smell changes are generally considered bothersome treatment symptoms. Ways to cope with taste or smell changes specifically were described by the children warranting further research and offering the opportunity for enhancing patient-centered care.
External evaluation of published population pharmacokinetic models of posaconazole

Population pharmacokinetic (PopPK) models of posaconazole have been established to promote the precision dosing. However, the performance of these models extrapolated to other centers has not been evaluated. This study aimed to conduct an external evaluation of published posaconazole PopPK models to evaluate their predictive performance. Posaconazole PopPK models screened from the PubMed and MEDLINE databases were evaluated using an external dataset of 213 trough concentration samples collected from 97 patients. Their predictive performance was evaluated by prediction-based diagnosis (prediction error), simulation-based diagnosis (visual predictive check), and Bayesian forecasting. In addition, external cohorts with and without proton pump inhibitor were used to evaluate the models respectively. Ten models suitable for the external dataset were finally included into the study. In prediction-based diagnostics, none of the models met pre-determined criteria for predictive indexes. Only M4, M6, and M10 demonstrated favorable simulations in visual predictive check. The prediction performance of M5, M7, M8, and M9 evaluated using the cohort without proton pump inhibitor showed a significant improvement compared to that evaluated using the whole cohort. Consistent with our expectations, Bayesian forecasting significantly improved the predictive per-formance of the models with two or three prior observations. In general, the applicability of these published posaconazole PopPK models extrapolated to our center was unsatisfactory. Prospective studies combined with therapeutic drug monitoring are needed to establish a PopPK model for posaconazole in the Chinese population to promote individualized dosing.
Performance and discriminatory capacity of Nutri-Score in branded foods in Greece

Background The harmonization of front-of-pack nutritional declaration is in the heart of food and nutrition policy discussions in Europe. The Nutri-Score system has been proposed by many countries as a potential candidate but its suitability for use across Europe is still under consideration. The current study aimed to evaluate the performance and discriminatory capacity of Nutri-Score in Greece and to test its alignment with the national food-based dietary guidelines. Materials and methods Data on the energy, saturated fat, total sugars, sodium, protein, and fiber content per 100°g or ml were extracted for all foods available (n = 4,002) in the Greek branded food composition database HelTH. Each food content in fruits, vegetables, pulses, nuts and oils was manually estimated from the ingredients list. The Nutri-Score algorithm was used both as a continuous (FSAm-NPS Score) and a categorical variable [Grades (A)–(E)]. Results The average FSAm-NPS Score in Greece was 8.52 ± 9.4. More than half of the solid foods (53.8%) were graded from (A) to (C), while most beverages (59.2%) were graded (E). More than 50% of food categories were populated with foods in all Nutri-Score grades, indicative of a good discriminatory capacity. The system scores favorably vegetables, pulses, and low-fat dairy products and unfavourablly sweets and processed meats showing in this way good alignment with the national guidelines. Eggs and seafood scored preferably compared to meat products. Animal fats received less favorable scores and so did cereal products that were highly processed. Discussion Nutri-Score showed good capacity to inform consumers toward better food choices in line with the national guidelines. It showed a potential to guide consumers and manufacturers toward less energy dense and more nutrient dense options and highlighted areas of improvement in the food supply.
Extracting the spectral index of the intergalactic magnetic field from radio polarizations

We explain the large scale correlations in radio polarization in terms of the correlations of galaxy cluster/supercluster magnetic field. Assuming that the polarization correlations closely follow the spatial correlations of the background magnetic field we recover the magnetic field spectral index as -2.74$\pm$0.04. This remarkably agrees with cluster magnetic field spectral index obtained in cosmological magneto-hydrodynamic simulations. We discuss possible physical scenarios in which the observed polarization alignment is plausible.