Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeting telomerase in HER2 positive breast cancer: role of cancer stem cells

s and Presentations Koziel JE and Herbert B-S. Targeting Telomerase in HER2 Positive Breast Cancer: Role of Cancer Stem Cells. 2013 Medical and Molecular Genetics Department Poster Session Koziel JE and Herbert B-S. Targeting Telomerase in HER2 Positive Breast Cancer: Role of Cancer Stem Cells. 2013 Cancer Research Day, IU Simon Cancer Center Koziel JE, Gryaznov S, Herbert B-S. (2013) Targeting Telomerase in HER2 Positive Breast Cancer: Role of Cancer Stem Cells. 2013 American Association for Cancer Research Annual Meeting: 2188 Koziel JE and Herbert B-S. Targeting Telomerase in HER2 Positive Breast Cancer: Role of Cancer Stem Cells. 2012 Medical and Molecular Genetics Department Poster Session Sauder CAM, Koziel JE, Choi M, Fox MJ, Badve S, Blosser RJ, Mathieson T, Rufenbarger CA, Henry JE, Storniolo AMV, Herbert B-S, Clare SE. Phenotypic Plasticity in the Normal Breast. 2012 American Association for Cancer Research Annual Meeting: 3322 Sauder CAM, Koziel JE, Choi M, Fox MJ, Badve S, Blosser RJ, Mathieson T, Rufenbarger CA, Henry JE, Storniolo AMV, Herbert B-S, Clare SE. Phenotypic Plasticity in the Normal Breast. 2011 San Antonio Breast Cancer Symposium (SABCS): P5-0502 Koziel, JE, Gentry E, and Herbert B-S. Targeting Telomerase in Recurrent and Metastatic Breast Cancer. 2011 Cancer Research Day, IU Simon Cancer Center Koziel JE, Brandau E, Shewmaker S, Lubrano A, Osterhage J. (2009) Investigating the Relationship Between Vacuolar Proteins and Telomere Length Regulation in Saccharomyces cerevisiae. Butler Undergraduate Research Conference. Conferences and Workshops Attended  Amelia Project for Breast Cancer Research (Indiana University, February 2011)  Breast Cancer Discovery Group Retreat (Purdue University, May 2011)  Mammary Stem Cell Training Course (Jackson Laboratory, June 2011)  San Antonio Breast Cancer Symposium (San Antonio, TX, December 2012)  American Association for Cancer Research Annual Meeting (Washington, D.C., April 2013)
ULTRASONIC ENERGY USAGE IN APPAREL INDUSTRY

Hizla gelisen teknoloji imalat endustrilerinde yeni yontemlerin uygulama alani bulmasini saglamaktadir. Bu yontemlerden bir tanesi de ultrasonik enerjinin konfeksiyon sanayiinde kullanilmasidir. Bu calismada, ultrasonik enerji kullanarak calisan kaynak (dikis) makinelerinin calisma prensipleri, olusturulabilecek kaynak tipleri, kullanim alanlari ve sagladiklari avantajlar sirasiyla incelenmistir. Farkli kumas tiplerinde, ultrasonik kaynak makinelerinde birlestirme islemini gerceklestiren yuzey elemani degistirildigi takdirde ortaya cikacak kaynak (dikis) mukavemet degisiklikleri arastirilmistir. Bu arastirma sirasinda ultrasonik birlestirme yontemlerinden ikisine ait mukavemetleri ile klasik dikis yontemlerinden cift baski dikisi mukavemeti ve kumas kopma mukavemeti karsilastirilmistir. Sonuc olarak islem suresi, kopma dayanimi acisindan ultrasonik kaynagin diger birlestirme yontemlerine gore daha avantajli oldugu gorulmektedir
Varicosities Induced Tarsal Tunnel Syndrome: A Case Report

A 54-year-old male patient suffered from numbness at the medial aspect of the right ankle for months. Tinel's sign was positive. Magnetic resonance imaging (MRI) showed serpentine and worm-like tubular structures within the tarsal tunnel with intermediate signal intensity on T1-weighted images, high signal intensity on T2-weighted images, and strong gadolinium-contrast enhancement, which allowed specific diagnosis of varicose veins. After failed nonoperative management for months, surgical decompression was performed and varicose veins compressing the posterior tibial nerve was found. The patient was symptom free during postoperative out-patient department follow-ups without recurrence for years.
VACCINATION EXTERNALITIES: THE CONCEPT AND APPLICATION IN PHARMACOECONOMIC STUDIES

ABSTRACT Objective: Externalities, could be positive or negative effects, occur in almost all daily life including vaccination activities. This paper aimed to presents a literature review of the concept of vaccination externalities and its application in pharmacoeconomic/economic evaluation studies. Methods: The literature review was conducted to achieve the study objectives. Searching of literature used MEDLINE electronic database by PubMed interface as well as Google scholar search engine and employed a number of keywords. Results: There are three most common types of vaccination externalities, namely: Herd immunity, serotype replacement, and antibiotic resistance. Herd immunity gives positive effects to the benefit of vaccination, the opposite of that of serotype replacement; while antibiotic resistance could give either positive or negative effects to the benefit of vaccination. Most emergence of serotype replacement occurred after pneumococcal conjugate vaccine vaccination. Most of pharmacoeconomic studies of vaccination used dynamic models to capture vaccination externalities which often included only herd immunity effects. Taking herd immunity into account in pharmacoeconomic studies tends to increase the outcomes and reduce the cost; hence, the cost per outcome or incremental cost-effectiveness ratio will decrease, resulting more favorable cost-effectiveness ratio. Conclusions: Vaccination externalities might have effect on the results of pharmacoeconomic studies. Attentiveness should be made to interpret the results of pharmacoeconomic studies which potentially altered by the effect of vaccination externalities. Keywords: Vaccination externality, Herd immunity, Serotype replacement, Antibiotic resistance, Pharmacoeconomic, Dynamic model.
Effect of dry-on, suffocation-based treatment on the prevalence of pediculosis among schoolchildren in Calagtangan Village, Miag-ao, Iloilo

ediculosis is an ectoparasitic disease caused by the infestation of the head lice Pediculus capitis. It has a high prevalence rate in developing countries because it is mistakenly considered as a naturally occurring disease among schoolchildren with no public health programs geared towards eradicating it. This study determined the prevalence of pediculosis among schoolchildren of Calagtangan Village, Miag-ao, Iloilo, and the percent reduction in the prevalence after treatment using a dry-on, suffocation-based pediculocide (Cetaphil). A mass screening of the schoolchildren of the village was performed by house-to-house survey. Results showed an overall prevalence of pediculosis of 85%, and significantly twice as many females (66%) afflicted compared to males (33%). Results also showed a marked decrease in the prevalence of pediculosis after the first week (44%) and last week (0.03%) of Cetaphil treatment. The overall cure rate was 97.2%. No topical or P systemic adverse reactions to the treatment modality were reported by the parents and/or children. This shows that the dry-on, suffocation based-pediculocide is effective in reducing the high prevalence rate of pediculosis in the study area.
WPP, No. 58: Vowel Quality: The relation between Universal and Language-specific Factors - eScholarship

u E i O U A e Vowel Qudlity the relation between universal and ldngudge-specific factors i e u t V a C 36 Ul _J e i a a D i o Ul e 5dndrd Ferrari Disner o u t ae i D o a e a o i e y ce. i a aa y UCLA Working Papers in Phonetics No. 56
Amphetamine Prescribing as a Harm Reduction Measure: A Preliminary Study

The study evaluated prescribing dexamphetamine for injecting primary amphetamine users. Subjects were prescribed dexamphetamine, up to 40mg daily, dispensed up to six times weekly. The treatment group were those 63 clients who had been prescribed dexamphetamine and fulfilled the study criteria. The control group comprised all 25 clients who fulfilled the same criteria but who had attended the service before dexamphetamine prescribing began. Three questions were addressed: does prescribing amphetamine attract high risk users, does it retain them in contact with the service and does it change behaviour. There were statistically significant increases in the number and proportion of amphetamine users attending the service and in the duration of contact with the treatment group. There were statistically significant reductions in the quantity and frequency of illicit amphetamine use, benzodiazepine use, money spent on drugs, injecting, needle sharing and track marks among the treatment group. Dexamphetamine pre.
Eating, drinking and physical activity in Faculty of Health Science students compared to other students at a South African university

Abstract Objectives: Students studying towards a qualification in Health Sciences should have more knowledge of a healthy lifestyle than other university students. However, it has been questioned whether or not these students apply such knowledge. While studies have been conducted on the lifestyle habits of students in general, few have compared the practices of Health Science students with those of other students. The objectives of this study were to compare the eating patterns, alcohol consumption and physical activity of Health Science students with those of other students. Design: A cross-sectional study design that utilised an electronic self-administered survey was applied. Data were analysed using SPSS® and Pearson’s chi-square test (p-value < 0.050). Subjects and setting: A convenience sample (n = 619), consisting of registered students at Nelson Mandela Metropolitan University, participated, after providing informed consent. Outcomes measures: Dietary patterns and frequency of intake, alcohol consumption and physical activity were measured. Results: A statistical difference was not reported between the eating patterns, alcohol consumption and physical activity of Health Science students and those of other students. Most of the students exhibited poor dietary behaviour. For example, 65% of Health Science students and 67% of students in other faculties consumed less than one fruit per day, 70% of Health Science students and 64% of other students consumed less than one vegetable per day, while 91% of Health Science students and 93% of students in other faculties consumed less than two glasses of milk per day. Although not significant, fewer Health Science students (4%) than students of other faculties (9%) consumed alcohol more than twice a week. Binge drinking was more common in Health Science students. Forty-eight per cent of the Health Science students indicated that they were physically inactive, compared to 49% of students in other faculties. Conclusion: Students studying Health Science do not have a healthier lifestyle than other students. Further theory-based intervention studies to determine the reasons for this behaviour need to be undertaken. Strategies should be developed to encourage behavioural change.
Women's decision making regarding hereditary breast and ovarian cancer risk-reducing strategies

Women found to carry mutations in the BRCA1 or BRCA2 genes have up to an 88% lifetime risk of breast cancer and up to a 65% lifetime risk of ovarian cancer. Strategies to address these heightened risks include breast cancer screening, and risk-reducing (RR) surgeries (i.e., mastectomy and salpingooophorectomy). Some women might change their lifestyle or use complementary and alternative medicine to prevent hereditary breast and ovarian cancer (HBOC). The objectives of this research were to describe: a) the HBOC RR strategies used by women prior to receiving their genetic test results, the influence of individual and psychological factors on the uptake of these strategies, and their risk management information needs, b) how women construct the ‘right time’ to consider RR surgery decisions, and c) the process of making decisions regarding HBOC RR strategies. A survey of 143 women was conducted to address the first objective and in-depth interviews with 22 BRCA1/2 carriers were conducted to address the remaining two objectives. Survey respondents engaged in breast cancer screening at the time of genetic testing and a sub-group modified their lifestyle to reduce their cancer risk. Qualitative analyses revealed women’s constructions of the ‘right time’ to consider RR surgery decisions to be when: (1) decisions fit into their lives, (2) they had enough time to think about decisions, (3) they were ready emotionally, (4) all the issues and conflicts were sorted out, (5) there were better options available, and (6) the health care system was ready for them. Grounded theory analyses suggested that the overarching process of making decisions about HBOC RR strategies was one of ‘preserving the self. ’ This process was shaped by the characteristics of health services, the nature of HBOC RR decisions, gendered roles, and the women’s perceived proximity to cancer. The women engaged in five decision-making styles, which were characterized by combinations of seven decision-making approaches. Findings from these three studies capture the diverse trajectories of decision making about HBOC risk management and highlight the role of personal and social context in shaping these decisions.
DIAGNOSIS OF TUBERCULOSIS UNDER RNTCP : EXAMINATION OF TWO OR THREE SPUTUM SPECIMENS

Summary: The Revised National Tuberculosis Control Programme (RNTCP) recommends examination of 3 sputum smears for diagnosis. This may not be practicable under all conditions, specially in difficult areas. It further adds to the cost of diagnosis and causes inconvenience to patients. In order to study the diagnostic yield of examining only two smears and the additional yield by the third smear, a retrospective study of the data from the RNTCP area of the LRS Institute was carried out for the years 1998 and 1999. In 1998, in all. 719 sputum positive patients were diagnosed out of 3738 new chest symptomatics examined (19.2%) and in 1999, there were 1044 sputum positive patients from 4189 new chest symptomatics examined (24.9%). The diagnostic yield of a single sputum specimen examined is insufficient under field conditions, especially where the sputum positivity is low. However, sputum positivity of two or more sputum smears did not affect diagnostic yield. Further, of the three sputum smears examined (spot. earl\' morning, spot), the early morning specimen had the best result. It is concluded that under field conditions, two sputum smears (one of which is early morning) is as effective as three smears for screening of chest symptomatics. Reduction in the number of smears to two is expected to reduce cost (both for patients as well as health care provider) without compromising quality. However, before changing national programme policy, more studies in different situations (rural areas, difficult areas, etc.) are recommended
The Effect of Aerobic and Walking Exercise on Physical and Psychological Symptoms and Pain of Premenstrual Syndrome

Background & Aims: Premenstrual Syndrome may have disabling effects on the person’s performance in the family and community. To relief from the symptoms of this syndrome, different methods such as safe exercise have been recommended. The aim of this study was to determine the effect of a three –month regular aerobic and walking exercise on physical and psychological symptoms and pain of premenstrual syndrome. Material and Methods: this Quasi-Experimental study was conducted on ٧ 0 volunteer 18-32 years old female students with at least 40% PMS symptoms. The Participants were randomly assigned into 3 groups of aerobic, walking and control. Aerobic group exercise 7 types of practice for 30 minutes daily for 3 months. The walking group practiced fast walking 30 minutes daily for 3 months. All of Participants completed the standard questionnaire of “Jack. Tips” for 3 times (before, 1 and 3 months after intervention). Data were analyzed using SPSS win (v.16) using one-way ANOVA. Significance level was considered as less than 0.05. Results: Pain reduction was significant at the end of first and third month of intervention (p=0.008, p=0.047). A significant difference was observed for physical symptoms after one menstruation cycle (p=0.001) although it was not significant after three menstruation cycles. No significant differences were observed in psychological symptoms after 1 and 3 cycles. Repeated measurement showed significant difference in physical symptoms of the 3 (P = 0.034). Conclusion: Three months of walking and aerobic exercise are very effective in reducing pain and Physical symptoms of premenstrual syndrome. Although aerobic exercise is more effective in reducing pain , but it does not create a significant improvement in psychological symptoms. Performing these two exercises are recommended to reduce the symptoms of premenstrual syndrome.
Knowledge, Attitude and Practice of Contraception Among Multiparous Women at Lady Aitchison Hospital, Lahore

To determine the level of awareness among multigravida regarding family planning methods and contraception coming to gynae outdoor of Lady Aitchison Hospital. This study was conducted at King Edward Medical University Lahore in one year (August, 2008 to July, 2009). This is a cross sectional survey of 600 women selected through systematic random sampling. This study included women 25 – 45 years of age in Para 4. Specific issues explored were the attitude towards family plan-ning, method preference, the level of contraceptive knowledge, awareness and perceived availability of methods, the current use of contraception, source of supply and the husbands influence on choosing contraceptive method. Among 600 women, 60% were aware of some contraceptive method. The most frequently used method was bilateral tubal ligation (BTL) (125) 20.83%. The use of intrauterine contraceptive device 83 13.08% was the second most common method followed by oral contraceptive pills (OCP) (37) 6.17%. (160) 26.67% women do not use any contraceptive method. The major reason for not using any method was the belief of being sterile, fear of side effects and to have more children. Educated women were (360) 60% more aware as compared to illiterate women (125) 20%. Green star and family planning centers remain the largest source of contraceptive services for Pakistani women. Key Words: Contraceptive use, multiparous women, family planning awareness, Knowledge Attitude and Practice – gap (knowledge attitude and practice – gap).
The Status of School Health Services: A Comparative Study of Primary Schools in a Developing Country

Background- The school health service is an important aspect of health delivery systems necessary to monitor the health of school children in other to keep them healthy and optimize their learning. Aims- This cross-sectional and descriptive study tried to ascertain the status of the school health services in 56 randomly selected schools using the school health programme evaluation scale. It also compared the extent of implementation of school health services in both private and public primary schools in Nnewi North Local Government Area (LGA) of Anambra state, Nigeria. Results- School health service is existent in the Nnewi North LGA but its implementation is suboptimal in both private and public schools. Significantly more private schools had treatment facilities within school premises (P=0.001), although routine screening of school pupils was done by more public schools (P=0.001). Overall, private schools had a significantly higher mean score (13.6±4.3 vs. 8.8±2.5) in criteria assessing school health services compared to public schools (P=0.001). Conclusion- School health service activities are present in Nnewi North LGA but implementation is suboptimal in both private and public schools. Effective policy with good monitoring and evaluation is imperative in ensuring adequate and optimal implementation of school health services in primary schools in Nnewi.
Healthcare Inequity and Physician Scarcity Empowering Non-Physician Healthcare

The massive scarcity of physicians in India, mainly in rural areas, prompted the Union Ministry of Health and Family Welfare to propose a three-and-a-half year Bachelor of Rural Health and Care degree designed exclusively to serve rural populations. The fierce opposition by powerful medical lobbies forced the proposal to fade away. This paper emphasises the importance of “task shifting” and “non-physician prescribing” in the global context and argues that non-physician healthcare providers would not only increase availability and accessibility to rural healthcare, but also provide an empowered second line of authority, adding to the checks and balances to the exploitative prestige-based hierarchy that pervades this knowledge-intensive service.
Observations and generation mechanisms of slow-mode waves in the magnetosheath

In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. • Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.
Effect of Aqueous Extract of Aegle Marmelos (Bael Leaves) on Perfused Toads Heart.

Introduction: Aegle marmelos/Bael leaves commonly used in day to day life of people as Prasad in LORD SHIVA TEMPLE as medicaments in household remedies. Few research has been done eliciting antifungal, antibacterial, antiprotozoal, hypoglycemic properties where as its cardiac effect has not been studied sufficiently till now. So this study is undertaken. Objective: To evaluate effect of Aqueous extract of leaves on perfused toads heart and to elucidate the possible mechanism of action. Material and Method: Aqueous extract of bael leaves was prepared and its effects on the perfused heart studied. GDR was studied and compared with known drugs on toads heart, on a smoked drum of kymograph and analysed. Result: BLE extract in lower doses increases both HR and amplitude of contraction and in higher doses transiently inhibit the heart, followed by further stimulation Conclusion: Aqueous extract of Aegle marmelos (bael leaves) has a unique stimulatory effect on Toads heart.
The effect of telephone support on the severity of nausea and vomiting in the first trimester of pregnancy in the primiparous women

Introduction: Nausea and vomiting occur in 70-85 of pregnancies which can be reduced by psychological support and some changes in the diet and lifestyle. With advances in technology, telephone is the most accessible option for the majority of people. This study was performed with the aim to determine the effect of telephone support on the severity of nausea and vomiting in the first trimester of pregnancy in the primiparous women. Methods: This clinical trial was performed on 60 pregnant women referred to the selected Health Care Centers in Mashhad in 2013. In the experimental group, telephone support was performed by the researcher for 15-20 minutes twice a week for four weeks. Control group only received routine care. Data were collected using demographic questionnaire, checklist to record phone calls, checklist to train the subjects with nausea and vomiting, and Modified Pregnancy-Unique Quantification of Emesis and Nausea questionnaire. Data were analyzed using SPSS software (version 16), and Chi-square, Independent t, Wilcoxon and Mann-Whitney tests. PResults: Mean score of nausea and vomiting was significantly different in experimental and control groups after intervention (P=0.028). The mean score of nausea and vomiting of pregnancy in the experimental group were significantly different before and after intervention (p<0.001). However, no such significant difference was seen in the control group (P=0.272). Conclusions: Telephone support reduces the severity of nausea and vomiting of pregnancy. So it is recommended as an accessible and effective approach.