Miracle-dz/UniFAR-FTUs huggingface dataset:
How the source of performance information matters to learning on the front-lines: evidence from a survey experiment

Abstract Despite the widespread implementation of performance management in public organizations, we know little about how contextual factors influence frontline employees’ perceptions of performance information. This study contributes to the literature by developing and empirically testing hypotheses stating that the source of the performance information matters to frontline employees’ perceptions and willingness to use performance information for learning purposes. We test the hypotheses in a survey experiment including 1926 public high school teachers in Denmark. The findings show that frontline employees exposed to performance information from vertical sources (the management) rather than from horizontal sources (colleagues in learning forums or the employees themselves) are less likely to perceive performance information as relevant and useful, and less willing to use the information for learning activities. The findings have important policy implications for the design of performance management in public organizations.
The Outcomes of an Adapted Tennis Program in Children and Adults with Developmental Disabilities

ii Acknowledgments. iii List of Tables . vii List of Figures . viii List of Abbreviations . xii Chapter 1 General Introduction . 1 Chapter 2 Improvements in tennis skills in adults with developmental and intellectual disabilities following an 8-week adapted tennis program . 10 Introduction . 10 Methods. 13 Participants . 13 Program . 16 Data Collection . 17 Statistical Analysis . 19 Results . 20 Discussion . 25 Limitations . 29 Conclusion and Future Directions . 30 Chapter 3 Behavioral Supports to Increase Skill Learning, On-Task Behavior, and Enjoyment of an Adapted Tennis Program (ACEing Autism) for Children and Adolescents with Autism Spectrum Disorder . 32 ACEing Autism . 34
GFF: Gated Fully Fusion for Semantic Segmentation

Semantic segmentation generates comprehensive understanding of scenes through densely predicting the category for each pixel. High-level features from Deep Convolutional Neural Networks already demonstrate their effectiveness in semantic segmentation tasks, however the coarse resolution of high-level features often leads to inferior results for small/thin objects where detailed information is important. It is natural to consider importing low level features to compensate for the lost detailed information in high-level features. Unfortunately, simply combining multi-level features suffers from the semantic gap among them. In this paper, we propose a new architecture, named Gated Fully Fusion(GFF), to selectively fuse features from multiple levels using gates in a fully connected way. Specifically, features at each level are enhanced by higher-level features with stronger semantics and lower-level features with more details, and gates are used to control the propagation of useful information which significantly reduces the noises during fusion. We achieve the state of the art results on four challenging scene parsing datasets including Cityscapes, Pascal Context, COCO-stuff and ADE20K.
Entrepreneurial Passion: A Review, Synthesis, and Agenda for Future Research

The present study undertakes a comprehensive and critical review of the body of empirical work on entrepreneurial passion. In particular, we document how the “first generation” of research on entrepreneurial passion and work passion in entrepreneurs has gained growing attention in various sub-fields of entrepreneurship research including entrepreneurial management, psychology, and finance. We provide an overview over theories used, definitions and measurements adopted, research methods utilized (e.g., qualitative vs. quantitative, survey-based vs. experimental/intervention), the thematic focus of studies, and unit of investigation (e.g., individual vs. team). We not only flag the problems of inconsistencies and limitations with respect to theory use, the making of causal inferences, and the conceptualization and measurement of entrepreneurial passion in existing studies (e.g., jingle fallacies), but also review the antecedents and outcomes of entrepreneurial passion identified in prior work and work where it had been examined as a moderator. Following this, we offer a research agenda with concrete suggestions to act as a foundation for the “second generation” of entrepreneurial passion research that proactively addresses the issues and gaps identified in our review. Finally, we also highlight how insights from the entrepreneurial passion literature can inform scholarship on passion more broadly.
AMPKα1 is essential for Glucocorticoid Receptor triggered anti-inflammatory macrophage activation

Macrophages are key immune cells which mediate both the acute inflammatory phase and the repair phase after tissue damage. Macrophages switch from pro-inflammatory to anti-inflammatory cells that sustain repair and return to tissue homeostasis. We show that the metabolic sensor, AMP-activated protein kinase (AMPK) is essential for glucocorticoid induction of an anti-inflammatory macrophage phenotype. While canonical gene regulation by glucocorticoids was not affected by loss of AMPK, we identified AMPK-dependent glucocorticoid-regulated genes in macrophages, related to efferocytosis. AMPK-deficient macrophages do not acquire phenotypic and functional anti-inflammatory features upon glucocorticoid exposure. We identified FOXO3 as an AMPK-dependent regulator of glucocorticoid activity in macrophages. Loss of AMPK in macrophages in vivo abrogates glucocorticoid anti-inflammatory actions during post-injury muscle regeneration and endotoxin induced acute lung injury. These data highlight that the glucocorticoid receptor is dependent on AMPK for its immunomodulatory actions in macrophages, linking their metabolic status to transcriptional control in resolving inflammation.
The Implementation Of Problem Based Learning and Jigsaw Model Learning to Improve Basic Programming Learning Outcomes

Basic Programming Learning in class X RPL1 in semester 1 has implemented the Problem Based Learning model and runs effectively until it reaches 90% results reaching KKM. Problems occur when there are changes in students in semester 2 because of the industrial class. School regulations state that industrial classes are students who are selected based on psychology and grades in semester 1. In semester 2 industrial classes are placed in class X RPL2 and students who do not enter the industrial class are made one in class X RPL1. The application of the Problem Based Learning model that was implemented previously became less effective, the data at the beginning of semester 2 there were no students from X RPL1 who reached KKM (Minimal Completeness Criteria). This type of research is a classroom action research (CAR). This study aims to measure the feasibility of the learning model and improve the learning outcomes of Class X RPL1 students on Basic Programming subjects by providing innovative learning models that combine the Problem Based Learning and JIGSAW models. The study was conducted in class X RPL 1 of SMK Turen, amounting to 34 students and carried out for 3 cycles. Each cycle consists of planning, implementing actions, observing, and reflecting. The results obtained, the feasibility of learning models in the first cycle reached 64%, in the second cycle amounted to 76%, and in the third cycle reached 92%. Learning outcomes in the first cycle of knowledge are the average value of students is 62.94 with a percentage of completeness of 44.12%. In cycle II has increased, the average value of students is 73.52 with a percentage of mastery learning by 70.59%, while in cycle III the average value of students is 79.71 with a percentage of completeness of 91.18%. Based on the results of the study it can be concluded that the implementation of the Problem Based Learning method and the JIGSAW model are able to improve the learning outcomes of Grade X RPL1 students in the Basic Programming of SMK Turen.
Meaningful Use of Electronic Health Records for Population Health Management in U.S. Acute Care Hospitals

Population health management (PHM) is used to identify the needs of a population and to align strategies to improve the health of the population through care coordination. The Health Information Technology for Economic and Clinical Health (HITECH) Act of 2009 emphasized the meaningful use (MU) of electronic health records (EHRs) to improve clinical and population health outcomes. The American Recovery and Reinvestment Act (ARRA) of 2009 approved the EHRs incentives program for eligible hospitals to demonstrate the MU of EHRs. Further, eligible hospitals which failed to demonstrate the MU of EHRs could face payment adjustments. Given a heightened focus on MU of EHRs for PHM and a reimbursement policy that incentivizes the MU of EHRs for PHM, EHRs can play an important role in PHM. Therefore, it is important to study the correlates of MU of EHRs for PHM in hospitals. This study examined the organizational and environmental correlates of the implementation of PHM objectives of MU of EHRs for PHM and the level of MU of EHRs for PHM in acute care hospitals in the United States (U.S). Three of the four dependent variables examined in this study were based on the three PHM objectives of MU of EHRs: 1) submission of electronic data to immunization registries, 2) submission of electronic data on reportable laboratory results to public health agencies, and 3) submission of electronic syndromic surveillance data to public health agencies. The level of MU of EHRs for PHM was a composite measure created using the aforementioned three PHM objectives. This study used resource dependency theory to derive the conceptual model based on its constructs of munificence, uncertainty, and interdependence. This study used an observational, retrospective, multiple correlational study design with a one-year lag for independent variables to address the research objectives. The data for this study were obtained from the American Hospital Association Annual Survey Database 2013, Area Health Resource Files 2015-2016, Centers of Medicare and Medicaid Stage 1 and Stage 2 MU datafiles for year 2014, and state health policy levers compendium 2011-2013. Due to the hierarchical nature of the data, mixed effects regression models were used for the analyses. The study found the munificence construct operationalized as the size of the hospital, uncertainty construct operationalized as market competition, and interdependence construct operationalized as system membership, ownership control, and the stage of MU implementation of EHRs to be significantly associated with the MU of EHRs for PHM.
Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism

Background Inborn errors of cholesterol metabolism occur as a result of mutations in the cholesterol synthesis pathway (CSP). Although mutations in the CSP cause a multiple congenital anomaly syndrome, craniofacial abnormalities are a hallmark phenotype associated with these disorders. Previous studies have established that mutation of the zebrafish hmgcs1 gene (Vu57 allele), which encodes the first enzyme in the CSP, causes defects in craniofacial development and abnormal neural crest cell (NCC) differentiation. However, the molecular mechanisms by which the products of the CSP disrupt NCC differentiation are not completely known. Cholesterol is known to regulate the activity of WNT signaling, an established regulator of NCC differentiation. We hypothesized that defects in cholesterol synthesis reduce WNT signaling, consequently resulting in abnormal craniofacial development. Methods To test our hypothesis we performed a combination of pharmaceutical inhibition, gene expression assays, and targeted rescue experiments to understand the function of CSP and WNT signaling during craniofacial development. Results We demonstrate reduced expression of axin2, a WNT downstream target gene in homozygous carriers of the Vu57 allele and in larvae treated with Ro-48-8071, which inhibits the synthesis of cholesterol. Moreover, activation of WNT signaling via treatment with a WNT agonist completely restored the craniofacial defects present in the Vu57 allele. Conclusions Collectively, these data suggest interplay between the CSP and WNT signaling during craniofacial development.
Prediction of meiosis-essential genes based on dynamic proteomes responsive to spermatogenesis

Mammalian meiosis is a specific cell division process during sexual reproduction, whereas a comprehensive proteome of the different meiotic stages has not been systematically investigated. Here, we isolated different types of spermatocytes from the testes of spermatogenesis-synchronized mice and quantified the corresponding proteomes with high-resolution mass spectrometry. A total of 8,002 proteins were identified in nine types of germ cells, and the protein signatures of spermatogenesis were characterized using the dynamic proteomes. A supervised machine learning package, FuncProFinder, was developed to predict meiosis-essential candidate genes based on changes in their protein abundance. Of the candidates without functional annotation, four of the ten genes with the highest prediction scores, Zcwpw1, Tesmin, 1700102P08Rik, and Kctd19, were validated as meiosis-essential genes using knockout mouse models. The proteomic analysis of spermatogenic cells provides a solid foundation for studying the mechanism of mammalian meiosis.
Efeitos adversos da morfina, metadona e tramadol no pós-operatório de cães submetidos à cirurgia da coluna vertebral: 180 casos (2011-2016)

RESUMO: A dor pós-operatória em cães que são submetidos a cirurgias da coluna vertebral é considerada severa e seu manejo inadequado pode influenciar no tempo de recuperação do paciente, na qualidade de vida e no resultado cirúrgico. Dentre os analgésicos indicados para uso no pós-operatório dessas cirurgias tem-se os opioides, que podem apresentar inúmeros efeitos adversos que requerem atenção. Devido à escassez de estudos clínicos acerca desse assunto em se tratando do pós-operatório de cães, objetivou-se com o presente estudo retrospectivo apresentar os efeitos adversos da morfina, metadona e tramadol utilizados no pós-operatório de cirurgias da coluna vertebral. Foram revisadas e avaliadas as fichas de 180 cães e anotadas as alterações observadas no pós-operatório e decorrentes do uso de opioides. Os principais efeitos adversos observados foram anorexia, hiporexia, vômito, salivação, vocalização, bradicardia, hipotermia, ofegação e sedação. Também foi observada persistência da dor em alguns cães mesmo com o uso de analgésicos. Houve diferença na ocorrência de anorexia nos cães tratados com morfina e nos tratados com metadona em relação aos tratados com tramadol. Ocorreu diferença também entre a observação de dor dos grupos morfina e tramadol. A associação de dipirona com morfina e com metadona não revelou diferença com relação à ocorrência de efeitos adversos, bem como a variação de doses. Conclui-se que a morfina, a metadona e o tramadol apresentam efeitos adversos quando empregados para tratamento da dor pós-operatória em cães submetidos à cirurgia da coluna vertebral; a anorexia, a hiporexia e o vômito foram os efeitos adversos frequentes com o uso de morfina e de metadona e, mesmo que o tramadol apresente menor ocorrência desses efeitos, seu uso, na dose estudada, pode não ser vantajoso quando se leva em consideração o grau de dor para cirurgias da coluna vertebral.
Outcome of early versus delayed Kirschner wire fixation of supracondylar fractures of humerus in children

Purpose: Controversy still persists regarding optimum intervention time for late presentations of supracondylar fracture of humerus in children. We compared outcomes in early and late groups of presentation and management. Study design: We conducted prospective study comparing early and late open reduction and Kirschner wire fixation for Gartland type III supracondylar fracture of humerus in children aged less than 16 years. We analyzed results of 27 cases in early group and 19(8 lost) cases in late group. We compared duration of surgery, range of motion, and Flynn’s criteria were used to evaluate outcome. Results: Thirty (65%) patients were male and 15(32.60%) had dominant limb involvement. Injury to surgery time was 53.63±41.03 hours in early group and 338.53±134.31 hours in late group (p
Elementary school teacher’s understanding on the scientific approach in natural science and mathematics subjects

This research is motivated by the urgency of applying a scientific approach to be able to equip students’ skills in facing the challenges of 21st century life. With the support of the results of previous research, this research aims to describe the understanding of elementary school teachers about the scientific approach and its implementation in the learning of natural sciences and mathematics subjects. The method of this research applied quantitative descriptive research. To be able to apply the scientific approach, teachers are not only armed with understanding but need to be supported by efforts to find other knowledge that can improve their self-efficacy. Most teachers know the scientific approach, but have not been able to apply the teaching and learning process systematically.
Preferred Modalities for learning Anatomy: Medical students' opinion

Learning anatomy is the basic and essential component of medical study when students start to learn in medical career. Since five hundred years ago, the human cadaver has been used as the silent mentor for students in learning anatomy. Later, pre-dissected specimens were used in addition to hands-on dissection of human cadaver. Current advances promote the use of anatomical models as well as plastinated specimens. This study focused on analyzing the preference of students towards different learning modalities available for anatomy teaching. It was conducted on first year medical students at the Faculty of Medicine and Health Sciences, University Malaysia Sabah (FPSK, UMS). A total of 76 students (27 males and 49 females) participated in this study. Out of 76 students, 57 (75%) students preferred using human cadaver for anatomy learning. Four students (5.3%) opted for plastinated specimen while 15 students (19.7%) chose the plastic model. Knowledge gained in learning Anatomy was said to be easier from cadaver (67.1%), followed by plastinated specimen (35.5%) and plastic models (52.6%). In the present study, 97.4% responded that plastic model was easier to apply their knowledge in objective structured practical examinations. The present study found that using cadaver was still favoured by medical students. Further studies are required to determine the preference between hands-on cadaveric dissections versus pre-dissected specimens.
Cortical morphology at birth reflects spatiotemporal patterns of gene expression in the fetal human brain

Interruption to gestation through preterm birth can significantly impact cortical development and have long-lasting adverse effects on neurodevelopmental outcome. We compared cortical morphology captured by high-resolution, multimodal MRI in n=292 healthy newborn infants (mean age at birth=39.9 weeks) with regional patterns of gene expression in the fetal cortex across gestation (n=156 samples from 16 brains, aged 12 to 37 post-conceptional weeks). We tested the hypothesis that noninvasive measures of cortical structure at birth mirror areal differences in cortical gene expression across gestation, and in a cohort of n=64 preterm infants (mean age at birth = 32.0 weeks), we tested whether cortical alterations observed after preterm birth were associated with altered gene expression in specific developmental cell populations. Neonatal cortical structure was aligned to differential patterns of cell-specific gene expression in the fetal cortex. Principal component analysis of six measures of cortical morphology and microstructure showed that cortical regions were ordered along a principal axis, with primary cortex clearly separated from heteromodal cortex. This axis was correlated to estimated tissue maturity, indexed by differential expression of genes expressed by progenitor cells and neurons; and engaged in stem cell differentiation, neuron migration and forebrain development. Preterm birth was associated with altered regional MRI metrics and patterns of differential gene expression in glial cell populations. The spatial patterning of gene expression in the developing cortex was thus mirrored by regional variation in cortical morphology and microstructure at term, and this was disrupted by preterm birth. This work provides a framework to link molecular mechanisms to noninvasive measures of cortical development in early life and highlights novel pathways to injury in neonatal populations at increased risk of neurodevelopmental disorder.
All-optical Spectral Shuffling Applied to 16-QAM Signals

All-optical spectral shuffling (AOSS) is a recently proposed physical layer encryption technique. In AOSS, multiple input signals are split in several spectral slices. These slices are then shuffled to form multiple encrypted signals. In fact, it is possible to transmit each shuffled signal by a different optical route. This strategy increases security because if an eavesdropper wants to detect information from a unique signal, he needs to tap at least one fiber per route. In this work, computer simulations are used to encrypt two 112 Gbps 16-quadrature amplitude modulation (QAM) signals and to propagate the shuffled signals by distinct optical routes. Our results reveal that the shuffled signals may be propagated by optical routes as long as 600 km. Besides that, we also investigate the situations i) where the signals travel by routes with different lengths and ii) where each route imposes different physical impairments to the encrypted signals.
CEO Values, Firm Long-Term Orientation, and Firm Innovation: Evidence from Chinese Manufacturing Firms

ABSTRACT Innovation contributes to a firm's long-term competitive advantages but also involves significant risk and uncertainty. As agency theory predicts, CEOs are self-interested and risk-averse, and thus are reluctant to engage in innovation investments. However, the extent to which CEOs are self-interested and the mechanisms through which self-interested CEOs affect firm innovation have not been empirically tested. To fill this gap, we propose that CEOs possess a mix of both self-preserving and other-regarding motives, and build a mediation model in which CEO values affect firm innovation via firms’ long-term orientation. Based on a three-phase (from 2014 to 2016) survey of 436 Chinese manufacturing firms, we find that CEOs with high self-regarding values reduce innovation efforts and performance by damaging a firm's long-term orientation. Moreover, CEO tenure, CEO duality, and environmental uncertainty weaken the relationship between CEO values and firm innovation via long-term orientation. Our study enriches the innovation literature by extending the basic assumptions of agency theory and by providing empirical evidence to determine whether and how self-regarded CEOs affect firm innovation.