Miracle-dz/UniFAR-FTUs huggingface dataset:
Vasopressin is life threatening for horses under isoflurane anaesthesia

The aim of the study was to examine the effects of vasopressin on the cardiovascular system of horses under isoflurane anaesthesia. For this purpose ten horses of various breeds were taken which had to be euthanized under general anaesthesia. Decision for euthanasia was made either during surgery or during radiographic examination due to diagnosis of a fatal condition. The horses consisted of 7 geldings, 2 mares, and 1 male foal, aged 14±8,5 (mean±SD) years and weighing 499,5±105,1 (mean±SD) kg. Before euthanasia was performed during general anaesthesia, vasopressin was administered. Five horses obtained an intravenous injection of 0,2IU vasopressin/kg and five horses were given an infusion of 0,08IU vasopressin/kg minute over a 10 minute period. Mean arterial blood pressure, heart rate, colour of mucous membranes, capillary refill time, ocular reflexes, ECG, and respiratory frequency and volume were determined. Furthermore, arterial blood gas analysis, capnography and pulse oximetry were performed. Additionally, cardiac ultrasound and heart auscultation were conducted in four horses. The results were that the blood pressure increased within 30–60 seconds of vasopressin administration and that all horses developed a high degree of ischemia of the mucous membranes during the 30–60 seconds after either vasopressin injection or vasopressin infusion. Eight horses died due to cardiac failure. Cardiac arrest occurred in four horses within 5 minutes of vasopressin injection as well as in four horses during the 10 minutes of vasopressin infusion. In four horses an ultrasound examination during vasopressin administration revealed acute cardio dilation causing cardiac arrest. It can be concluded that Vasopressin is fatal for horses under general anaesthesia. The use of vasopressin must be avoided in horses. Vasopressin must not be used as an alternative drug for adrenaline in horses.
Glycemic Control and Hospital Admission Risk in Type 1 Diabetes is Related to the Use of Carbohydrate Counting and Frequency of Self- Monitoring of Blood Glucose: RSD1 Study

Introduction and objectives: Diabetes mellitus type 1 (DM1) represents 5–10% of the total prevalence of diabetes. Few studies exist to demographically and clinically describe DM1. Subjects and methods: observational, cross-sectional study of patients with DM1 over 14 years of age treated by hospital endocrinologist. Results: 221 patients (104 men, 37.5 ± 12.7 years) from seven hospitals. Caucasian 97%; Education: primary 22.7%, secondary 48.5%, university 25.3%. Anthropometric data (average ± SD): Weight 70.1 ± 13.7 kg; Height 166.5 ± 8.8 cm; BMI: 25 ± 3.8 kg/m2; Waist circumference: 87.3 ± 18 cm. Family history: DM (46.3%, DM1 28.3%, DM2 71.7%), thyroid disease (17.6%), early CVD (6.5%). Active smoker 20%, ex-smoker 18.6%. DM1 duration: 15.8 ± 10.2 years. Treatment: basal + bolus 74.7%; premixed insulin: 5.7%, basal 2.7%, CSII: 17.1%; metformin: 8.5%; Self-monitoring of blood glucose (SMBG) frequency: 3.6 ± 1.4 times/day; Uses insulin/carbohydrates ratio: 38.8%; regular physical activity: 55.6%; Lipid-lowering drugs: 29.1%; antihypertensive agents: 23.5%. Metabolic control: HbA1c = 7.7 ± 1.3% (61 ± 9 mmol/l); Poor adherence to diet (p < 0.001), number of SMBG (p < 0.01) and regular physical activity (p < 0.05) explains 34.2% of the changes in Hb1Ac. Risk of hospital admission is reduced with the use of carbohydrate counting (OR 0.39, p = 0.002) and with the largest number of blood glucose controls (OR 0.65, p = 0.007). Conclusions: More efforts are necessary to improve the overall metabolic control of patients with DM1. Epidemiological studies aimed at DM1 populations are necessary in order to define the necessary resources.
Case Study to Analyze the Impact of Multi-Course Project-Based Learning Approach on Education for Sustainable Development

This work presents a multi-course project-based learning (MPL) approach implemented using two electrical engineering (EE) interdisciplinary undergraduate courses at Qatar University. Implementing an MPL approach helps in the development of critical thinking and collaborative decision-making skills. The attainment of these skills is also the outcome of education for sustainable development (ESD); the skills help students acquire the knowledge, attitudes, and values necessary to shape a sustainable future. The participating students’ worked on a design project, which was used to assess the fulfillment of a set of student learning outcomes (SLOs), focusing on engineering soft skills and project management skills. The skills include the ability to communicate effectively, to work collaboratively in a team, to think both critically and creatively, and to manage projects efficiently with realistic constraints and standards. The challenges of implementing the MPL method are the organization of pedagogical activities that are planned for each of the courses involved, the coordination of the materials delivered by each course, and the supervision of around 90 students per year performing the MPL method. The experience of MPL deployment in the EE program was rated using student surveys. It was assumed that the MPL approach would be beneficial to the students based on the instructors’ and students’ feedback from the same courses in previous years. This was verified using chi-square statistics of the survey results. The implementation of the MPL also helped in increasing the average marks scored by the students in the design project. Some interesting feedback, statistical analyses, and improvement actions are reported for future upgrades. This work also contributes to the MPL pragmatic body of knowledge by exploring a successful initiative and its outcomes, which can help in attaining the skills needed for ESD.
Emotion Dysregulation and Early Trauma in Borderline Personality Disorder: An Exploratory Study

Background: Borderline personality disorder (BPD) research is in its nascent stage in India though studies have estimated its prevalence in psychiatric conditions. Trauma experiences and emotion regulation difficulties are well documented in BPD in the international literature. Thus, it is imperative to examine the role of trauma experiences and their relation to emotion dysregulation in BPD in the Indian context. Materials and Methods: This study used both self-report and semistructured interview data from 34 adults with BPD who presented for outpatient or inpatient psychiatric treatment and compared them with a gender-matched control group. The tools used were the International Personality Disorder Examination, Kessler-10, Early Trauma Inventory Self Report-Short Form, modified-Positive And Negative Affect Scale, Cognitive Emotion Regulation Questionnaire, and Difficulties in Emotion Regulation Scale (DERS). Results: The BPD group reported higher negative affect, increased use of maladaptive emotion regulation strategies and a deficit of adaptive strategies, after depression scores were controlled for. General abuse, physical punishment, and emotional abuse were significantly higher in the BPD group. The high occurrence of childhood emotional abuse and negative affect in BPD patients emerged as a major correlate accounting for 68.4% of the variance in DERS scores. Conclusions: Although we obtained results similar to the western literature on BPD pathology, sociocultural factors such as family and economic conditions, cultural differences in symptom expression of BPD, and treatment forms used in India warrant further research.
A Comparison of Policy Analysis of Palliative Care for Cancer in UK, Malaysia, and South Africa

Context: Cancer is one of the leading causes of death globally. It changes the patient’s life, and not only causes many physical and emotional symptoms but also reduces the quality of life (QOL) in patients during the advanced stages of cancer. Today, the main approach in taking care of these patients is to provide supportive and palliative care with the aim of enhancing the QOL in patientsandtheirfamiliesandtoreducethecostof treatmentandhealthcare. Thisstudywasconductedwiththeaimof comparing the policies and the strategies related to cancer supportive and palliative care in the selected countries, using the World Health Organization (WHO) guideline in the United Kingdom (UK), Malaysia, and South Africa. Evidence Acquisition: This study is a comparative study. The data were collected through reviewing scientiﬁc and administrative documents, WHO website and reports, the Ministry of health websites, and other authoritative websites. The search was done through texts in English and the databases, including Science Direct, Scopus, and PubMed between 2000 and December 2018. We usedastrategysearchaccordingtoMedicalSubjectHeadings,usingthekeywords(cancer,palliativecare,supportivecare,patients, policies,programs,strategies,UK,Malaysia,andSouthAfrica). Thedatawereanalyzedbycontentanalysisapproach,usingMAXQDA software version 11. Results: The rates of cancer and mortality diﬀered according to the health diﬀerences in the selected countries. With regard to palliative care, various policies and programs were implemented. The implementation of more policies was carried out by the Ministry of Health. In some countries, adequate funding was available to support programs. Countries have been trying to provide decentmanpowertoprovideservices. Despitethesuccessesachievedinimplementingpalliativecareprograms,somefactors,such as inadequate healthcare structures and insuﬃcient ﬁnancial resources have caused problems in implementing programs. Conclusions: Countriesshouldconsiderpalliativecareasoneof theimportantprioritiesof thehealthsystemandawayof enhanc-ingQOLinpatientswithcancerandtheirfamilies,andwithregardtothecontextof eachcountry,focusingoneachareaof practical guide, reviewing the status and available facilities, and learning from the experiences of other countries should be considered to achieve this goal.
FACTORS EXPLAINING URBAN LAND VALUE VARIABILITY: A CASE STUDY IN ATAKUM DISTRICT, SAMSUN-TURKEY

The objective of this study was to determine the factors affecting urban land prices in Atakum district of Samsun province, Turkey. Agricultural lands in Atakum changed to urban lands especially within the last 20 years due to increasing population and public facilities such as; roads, tram line, schools, etc. Data used in this study were collected in questionnaires on 64 land parcels sold by real estate agents in 2017. The factors affecting urban land prices were determined with Hedonic Price Analysis. The significance of model parameters was tested, and the variability of land prices was verified for the hypothesized relationships between the significant parameters and the parcel price. The significant factors affecting urban land price were distance to coast, floor area ratio, parcel size, parcel shape, distance to tram station, post office and bus station.
Genetic Variation in Interleukin-28B and Response to Peg-IFNα-2a/RBV Combination Therapy in Patients with Hepatitis C Virus Infection

Background: The hepatitis C virus (HCV) infection is one of the major causes of progressive liver diseases worldwide. Despite the new treatments for HCV infection, antiviral therapy with a combination of pegylated interferon- α 2a plus ribavirin (Peg-IFN α -2a/RBV) is still used in developing countries. Objectives: The aim of the current study was to determine the relationship between rs12979860 polymorphism in the interleukin 28B gene (IL28B) and response to Peg-IFN α -2a/RBV combination therapy in Azerbaijani patients with chronic HCV infection. Methods: Atotalof 72AzerbaijanipatientswithestablishedchronicHCV-1btookpartinthiscross-sectionalstudybetweenJanuary 2010 and September 2015. Genomic DNA was extracted from peripheral blood mononuclear cells (PBMCs) of the patients and the rs12979860 single nucleotide polymorphism was diagnosed by polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Results: Themeanageof thepatientswas36.9 ± 12.4(rangeof 27-57years)and42(58.3%)outof 72weremale. Concerningthe IL28B polymorphism in rs12979860, the results indicated the presence of CC, CT, and TT genotypes in 24 (33.3%), 42 (58.3%), and 6 (8.3%) patients, respectively. There was a signiﬁcant association between IL28B genotypes and response to HCV combination therapy with peg-IFN α -2a/RBV (P = 0.001). Conclusions: Theresultsof thisstudyindicatethatthers12979860CCgenotypeof IL28B wasassociatedwitharesponsetoPeg-IFN α -2a/RBVcombinationtherapyinAzerbaijanipatientswithHCV-1binfection. Therefore, hostgeneticsmaybeusefulinpredictingthe response to hepatitis C treatment.
Corollary discharge promotes a sustained motor state in a neural circuit for navigation

Animals exhibit behavioral and neural responses that persist on longer time scales than transient or fluctuating stimulus inputs. Here, we report that C. elegans uses feedback from the motor circuit to a sensory processing interneuron to sustain its motor state during thermotactic navigation. By imaging circuit activity in behaving animals, we show that a principal postsynaptic partner of the AFD thermosensory neuron, the AIY interneuron, encodes both temperature and motor state information. By optogenetic and genetic manipulation of this circuit, we demonstrate that the motor state representation in AIY is a corollary discharge signal. RIM, an interneuron that is connected with premotor interneurons, is required for this corollary discharge. Ablation of RIM eliminates the motor representation in AIY, allows thermosensory representations to reach downstream premotor interneurons, and reduces the animal’s ability to sustain forward movements during thermotaxis. We propose that feedback from the motor circuit to the sensory processing circuit underlies a positive feedback mechanism to generate persistent neural activity and sustained behavioral patterns in a sensorimotor transformation.
The Effects of Government Characteristics, Complexity, Audit Findings, and Audit Opinions on the Level of Provincial Government Financial Statement Disclosures in Indonesia

This research aims to analyze the effect of government characteristics, complexity, audit findings, and audit opinions on financial statement disclosures on the level of the provincial government in Indonesia. The government institutions were selected based on the following characteristics: the government age (how long it has been established), regional wealth, intergovernmental revenue, and leverage. The research employed functional differentiation. The total samples were 198 consisting of 33 provincial financial reports in Indonesia for six years. The samples were obtained using a purposive sampling method and processed using Eviews 7. The results showed that the government age, regional wealth, intergovernmental revenue, leverage, and the audit opinions had a significant positive effect on the level of government financial statement disclosures; while functional differentiation and audit findings did not affect the level of government financial statement disclosures. The average level of provincial government financial statement disclosures in Indonesia from 2012-2017 was 47%.
Thermal, structure, and rheological properties of native potato flour prepared under different combined drying methods

Abstract Native potato flour is one of the functional additives for dough making in food processing to meet the increasing healthy food requirements. To explore an efficient combination drying methods for native potato flour processing, different drying treatments including hot air (AD), freeze-drying (FD) and radio frequency (RFD) were introduced and investigated in this study. The associated color, thermal, pasting, crystalline, rheological, and morphological properties of the potato flour were investigated and evaluated systematically. The gelatinization temperature of potato flour increased from 63.73 to 69.47 °C with drying temperature increased, which indicated the thermal stability of the flour can be strengthened by drying temperature. The gelatinization enthalpy, viscosity, and relative crystallinity of the dried potato flours decreased as the treatment temperature increase, which indicated the extension of thermal denature as the effect of increasing drying temperature. It is worth to note that the RFD combined method has the most efficient drying rate and moderate heat damage. Therefore, combined drying methods are meaningful for native potato flour processing, which might be valuable for industrial development.
The effects of primary and secondary wound closure following surgical extraction of lower third molars on post-operative morbidity: A prospective randomized clinical trial

The aim of this study was to compare the effects of primary and secondary wound closure on post-operative pain, swelling, and acute alveolar ostietis (AO) after surgical extraction of partially impacted lower third molars. A prospective randomized parallel clinical trial was conducted on 60 patients. Exclusion criteria included pericoronal infection and uncontrolled systemic diseases. Pain was estimated preoperatively. Facial measurements (FM) were obtained using a measuring tape for three lines between five defined points on the face. A single extraction with envelope flap was performed. Two types of wound closures were adopted, primary in Group 1 (G1) and secondary in Group 2 (G2). Pain, FM, and AO were evaluated on days 3 and 7. In both groups, FM and pain significantly increased on day 3, and then decreased on day 7. The amount of increase in FM, pain, and empty socket was higher in G1 than in G2. Tenderness and halitosis were more prevalent in G2 than in G1 on day 3. Five cases of AO were found in G1 (16.7%) and 4 cases in G2 (13.3%). No significant differences were found between the two groups regarding these variables. When the envelope flap is used, secondary wound closure has insignificant advantages over primary closure with respect to swelling, pain, and AO. Key words: Primary closure, secondary, third molar, extraction.
Topology comparison of Twitter diffusion networks reliably reveals disinformation news

In recent years, malicious information had an explosive growth in social media, with serious social and political backlashes. Recent important studies, featuring large-scale analyses, have produced deeper knowledge about this phenomenon, showing that disinformation spreads faster, deeper and more broadly than the truth on social media, where bots and echo chambers play an important role in diffusion networks. Following these directions, we explore the possibility of classifying news articles circulating on social media based exclusively on a topological analysis of their diffusion networks. To this aim we collected a large dataset of networks on Twitter pertaining to news articles published on two distinct classes of sources, namely outlets that convey mainstream, reliable and objective information and those that fabricate and disseminate various kinds of disinformation stories. We carried out an extensive comparison of these networks using several alignment-free approaches including basic network properties, centrality measures distributions, and network distances. We accordingly evaluated to what extent these features allow to discriminate between the networks associated to the aforementioned news domains. Our results highlight that the communities of users spreading mainstream rather than disinformation news tend to shape diffusion networks with subtle yet systematic differences. This opens the way to promptly and correctly identifying disinformation on social media by solely inspecting the resulting diffusion networks.
Characterization of Silver-Doped LiF Crystal Grown by Czochralski Technique for Dark Matter Search Application

In this article, the growth, luminescence, and scintillation properties of a silver-doped LiF crystal grown by the Czochralski technique are studied. The absorption spectrum of the crystal is measured at room temperature and optical energy bandgap of the crystal is calculated as ~5.2 eV. The luminescence and scintillation properties of the crystal are studied at different temperatures (10–550 K) under the excitations with X-ray, 266-nm laser, 280-nm light emitting diode (LED), and 90Sr beta source. The crystal shows a violet emission (~405 nm) under the excitation of a 280-nm LED source. The luminescence decay time of the crystal is measured from room temperature (300 K) to 10 K under the excitation of the 266-nm laser source. The decay time curves are fit with 2-exponential (300–200 K) and 3-exponential (175–10 K) decay functions. The shortest ( $27.2~\mu \text{s}$ ) and the longest decay time ( $42.8~\mu \text{s}$ ) of the crystal are obtained at 300 and 75 K, respectively. Thermoluminescence (TL) measurements were carried out from 10 to 300 K and 325 to 550 K in order to investigate the presence of trap centers. The different kinematic parameters such as order of kinematics, trap depth, and frequency factor are calculated for the observed TL peaks. The scintillation light yield of the crystal is measured with a continuous single photon counting technique using a 90Sr beta source in the temperature range from 300 to 10 K. In this article, we will emphasize the potentiality of a Li-based crystal for dark matter search applications.
A Lifespan Perspective on the Interconnections Between Personality, Health, and Optimal Aging

The seeds of Healthy Aging are sown much earlier in life, through the health choices we make in younger adulthood and midlife. Cumulative effects of good health behaviors throughout one's life often pay off in older adulthood, in the form of healthy aging (optimal physical, cognitive, and psychological functioning), whereas poorer choices earlier in life can lead to suboptimal or even pathological aging. Personality characteristics are important predictors of health behaviors and thus influence the course of healthy aging. Personality also impacts other precursors to healthy aging, such as educational attainment, work and career choices, financial success, relationship and family outcomes, and attitudes toward engagement and involvement in later life. Through multiple pathways, not only health and health behavior, personality predicts positive aging-related outcomes.