Miracle-dz/UniFAR-FTUs huggingface dataset:
Covid-19 Clinical Course and Blood Groups: Turkish Population-Based Study.

BACKGROUND/AIM SARS-CoV-2 enters the cell through the binding of the S glycoprotein on the surface of the virus to the angiotensin-converting enzyme 2 (ACE-2) in the host cells and also SARS-CoV S protein binding to ACE-2 was inhibited by anti-A antibodies. The aim of the study was to investigate the relationship between blood groups and the course of COVID-19 in Turkey. MATERIALS AND METHODS Laboratory confirmed COVID-19 patients aged 18 and over (n=39.850) were randomized in age and gender-matched groups according to blood groups Results: Advanced age, male gender and blood group A were found to be related with increased rate of intensive care unit (ICU) admission (OR =1.089, 95% CI: 1.085-1.093 for age; OR=1.963, 95% CI: 1.737-2.218 for male gender; OR=1.216, 95% CI: 1.023-1.446 for blood group A). When blood group O individuals were compared to non-O individuals, no significant difference was observed regarding the rate of hospital and ICU admission, mechanical ventilation (MV) support, length of hospital and ICU stay, and case fatality rate (CFR). The CFR in patients with blood group A, B, O, and AB were 2.6%, 2.2%, 3.1%, and 2.3%, respectively. There were no significant differences between Rh-negative and positive patients regarding the rate of hospital and ICU admission (p=0.280 and p=0.741, respectively), also the rate of MV support and CFR was similar (p=0.933 and p= 0.417). CONCLUSION Our study revealed that ABO and Rh blood groups do not have any impact on the rate of hospital admission, hospital and ICU stay, MV support, and CFR.
Development of a Measure of Calculative Mindset (CM): Establishing a Nomological Net and Predictive Utility of the CM Measure

A calculative mindset (CM) describes the tendency to analyze and convert qualitative social values into numeric or monetary metrics and is a predisposition that shapes behaviors and actions of the employee. CM has been manipulated in experimental studies, but it has not been investigated in field research due to the absence of a scale to measure CM. In study 1, we followed Hinkin’s scale development protocol to conceptualize, develop, and validate a measure of CM to facilirate research in organizational contexts. In Study 2, we examined the relationship between CM and measures of performance, counterproductive work behavior (CWB), organizational citizenship behaviors (OCB), and in role-performance (IRP). Results from hierarchical regression analyses indicate that CM is related to these performance outcomes and explains incremental variance over established measures of the Five-Factor Model of personality. Implications for personality research, selection of human resources, and facilitation of an ethical workplace are discussed.
A new species of Liphistius from Myanmar and description of the actual male of L.birmanicus Thorell, 1897 (Araneae, Mesothelae, Liphistiidae)

Abstract Five Liphistius Schiödte, 1849 species of the primitively segmented spider family Liphistiidae are currently known from Myanmar. Here, we described a new species, Liphistiuspyinoolwinsp. nov. (♂♀), which was collected from Pyin Oo Lwin, Mandalay Region, Myanmar, diagnosed based on its genital morphology. The specimens (2♂♂, 5♀♀) collected by Walter C. Sedgwick from Pyin Oo Lwin in 1982 were misidentified as L.birmanicus Thorell, 1897 and are treated here as the newly described species. Accordingly, we described the males of L.birmanicus for the first time, redescribed its female, using newly collected specimens from Yadò, Than Taung and Kalekho Atet townships, Kayin State. We also provided information on the variation in genital morphology of both species, and their relationships within the birmanicus-group of species.
Mycena citrinomarginata is associated with roots of the perennial grass Festuca roemeri in Pacific Northwest prairies

ABSTRACT Prairies in the Pacific Northwest are dominated by perennial bunchgrasses. A Mycena in the citrinomarginata complex was observed to tightly co-occur with bunchgrasses at several prairie study sites. Mapping and spatial statistics showed that it was strongly and significantly associated with Festuca roemeri tussocks. We further found that this fungus is attached to F. roemeri roots (17/17 examined) and both specific primers and next-generation DNA sequencing established that the fungus is in the roots, suggesting that M. citrinomarginata may be endophytic or biotrophic in some contexts, and not simply saprotrophic. These results combined with a literature review indicate that Mycena species are often found as endophytes in grass roots. Given the importance of grasses and grasslands for humans, this ecological association deserves further study.
Climate warming dominates over plant genotype in shaping the seasonal trajectory of foliar fungal communities on oak.

Leaves interact with a wealth of microorganisms. Among these, fungi are highly diverse, and are known to contribute to plant health, leaf senescence and early decomposition. However, patterns and drivers of the seasonal dynamics of foliar fungal communities are poorly understood. We used a multi-factorial experiment to investigate the influence of warming and tree genotype on the foliar fungal community on the pedunculate oak Quercus robur across one growing season. Fungal species richness increased, evenness tended to decrease, and community composition strongly shifted during the growing season. Yeasts increased in relative abundance as the season progressed, while putative fungal pathogens decreased. Warming decreased species richness, reduced evenness and changed community composition, especially in the end of the growing season. Warming also negatively affected putative fungal pathogens. We only detected a minor imprint of tree genotype and warming-by-genotype interactions on species richness and community composition. Overall, our findings demonstrate that warming plays a larger role than plant genotype in shaping the seasonal dynamics of the foliar fungal community on oak. These warming-induced shifts in the foliar fungal community may have a pronounced impact on plant health, plant-fungal interactions and ecosystem functions.
Characteristics and outcome of human immunodeficiency virus (HIV)‐associated primary effusion lymphoma as observed in the German HIV‐related lymphoma cohort study

ier Paris Seine Saint Denis, Hôpital Avicenne, AP-HP, Bobigny, Hematology Department, Saint-Vincent Hospital, GHICL, Service de M edecine Interne et Immunologie Clinique, Centre de r ef erence des maladies autoimmunes syst emiques rares du Nord et Nord-Ouest de France (CeRAINO), Univ. Lille, Inserm, CHU Lille, U1286 INFINITE Institute for Translational Research in Inflammation, F-59000, Lille, UMR CNRS 6015-INSERM U1083, Mitolab Team, MITOVASC Institute, University, Department of Internal Medicine, Angers University Hospital, Angers, CNRS-UMR 5164 Immuno ConcEpT, Bordeaux University, Department of Internal Medicine, Bordeaux University Hospital, Bordeaux, Intensive Care Medicine, INSERM CIC 1415, CRICS-TriggerSep Research Network, CHRU de Tours, 37044, Tours, Internal Medicine and Clinical Immunology, CHU Rennes, Rennes, Internal Medicine and Hematological Unit, Centre Hospitalier de Dax, Dax, Departement of Clinical Research, Paris Seine Saint Denis Hospital, Sorbonne Paris University, AP HP, Bobigny, CHU de Bordeaux, Hôpital Saint-Andr e, Service de M edecine Interne et Maladies Infectieuses and Universit e de Bordeaux, INSERM U1219, BPH, F-3300, Bordeaux, Department of Clinical Hematology, Necker Children’s Hospital, AP HP, Paris and Departement of Clinical Research, Paris Seine Saint Denis Hospital, Sorbonne Paris University, AP HP, Bobigny, France. E-mail: coralie.bloch-queyrat@aphp.fr
Integrating visual search, eye movement training and reversing prism exposure in the treatment of Balint-Holmes syndrome: a single case report

ABSTRACT Objective For the first time, we administered reversing prism exposure to treat optic ataxia in a single patient with Balint-Holmes Syndrome (BHS), who also underwent specific trainings for simultanagnosia and ocular apraxia. Method and Results By an introduction and withdrawal experimental design, we observed that the active treatment periods improved patient’s visuospatial defects and functional autonomy. Conclusions We thus provided a proof of principle supporting the use of reversing prism exposure in optic ataxia within an integrated and personalized rehabilitative approach for BHS.
Diabetes Mellitus and the Development of Lumbar Canal Stenosis: Is There Any Relevance?

Study Design Retrospective study. Purpose To assess the relationship between the severity of lumbar canal stenosis (LCS) and type-II diabetes mellitus (DM). Overview of Literature DM is a multiorgan disorder that has an effect on all types of connective tissues. LCS is a narrowing of the spinal canal with nerve root impingement that causes neurological claudication and radiculopathy. Identification of the risk factors of LCS is key in the prevention of its onset or progression. Methods LCS patients were divided into three groups as per DM status: group A without DM (n=150); group B patients with well-controlled DM; and group C patients with uncontrolled DM. Groups B and C were subdivided into group B1: patients with DM with a duration of ≤10 years (n=76), group B2: DM with duration of >10 years (n=68), group-C1 DM duration ≤10 years (n=56), and group C2 DM duration >10 years (n=48). The severity of LCS was evaluated using the Swiss Spinal Stenosis Scale (SSSS) and Modified Oswestry Disability score (MODS). Operated patients ligamentum flavum sent for histological staining and quantitative immunofluorescence analysis. Results The demographic data of groups did not show any difference except in age. There was no difference between the mean SSSS and MODS of groups A and B1. Groups B2, C1, and C2 had higher average SSSS and MODS than group A (p<0.05). Groups B2 and C2 had higher SSSS and MODS than groups B1 and C1. Groups C1 and C2 had higher scores than groups B1 and B2 (p<0.05). The severity of LCS was significantly related to the duration of DM in groups B and C (p<0.05). Uncontrolled and longer duration of DM had significant elastin fibers loss and also higher rate of disk apoptosis, high matrix aggrecan fragmentation, and high disk glycosaminoglycan content. Conclusions Longer duration and uncontrolled diabetes were risk factors for LCS and directly correlate with the severity of LCS.
Emotional stress & decision-making: an emotional stressor significantly reduces loss aversion

Abstract Stress influences loss aversion, the principle that losses loom larger than gains, although the nature of this relationship is unclear. Studies show that stress reduces loss aversion; however, stress response has been only studied by means of physiological measures, but the stressor emotional impact remained unclear. Since emotions can modify stress response and increase the activity of the loss aversion neural substrates, it could be expected that an emotional stressor may produce the opposite effect, i.e. loss aversion increase. 69 participants were divided into experimental and control group. The first one was exposed to emotional stress through a 5-minutes video, and control group viewed a match-length distractor video. Physiological stress response was assessed by means of electrodermal activity (EDA), and both perceived stress, and negative affect (i.e. psychological stress response) were registered through questionnaires. Both groups performed a mixed gamble task, which allowed the extraction of loss aversion through a Bayesian-computational model. During and after video, experimental group had higher electrodermal activity, perceived stress, and negative affect than controls, suggesting that emotional stress induction was effective. However, rather than increasing, loss aversion of stressed participants was lower. These results constitute a new evidence of emotional stress influencing loss aversion and highlight that stress, regardless of its emotional impact, can reduce this phenomenon. These results should be considered when predicting risky decisions.
Increased myocellular lipid and IGFBP‐3 expression in a pre‐clinical model of pancreatic cancer‐related skeletal muscle wasting

Skeletal muscle wasting (SMW) in cancer patients is associated with increased morbidity, mortality, treatment intolerance and discontinuation, and poor quality of life. This is particularly true for patients with pancreatic ductal adenocarcinoma (PDAC), as over 85% experience SMW, which is responsible for ~30% of patient deaths. While the established paradigm to explain SMW posits that muscle catabolism from systemic inflammation and nutritional deficiencies, the cause of death, and the cellular and molecular mechanisms responsible remain to be elucidated. To address this, we investigated the relationship between tumour burden and survival in the KCKO murine PDAC model.
Pediatric home confinement due to COVID‐19: Somatic and anxiety spectrum consequences

Abstract Aims and Objectives We aimed to determine the impact of COVID‐19 related home confinement on the paediatric population by focusing on anxiety, behavioural disturbances and somatic symptoms. Background To limit the spread of the COVID‐19 outbreak, governments have imposed nationwide lockdowns to prevent direct contact; this has affected everyday lives and activities such as attending school classes. Such isolation may have impacted children’s anxiety levels. Design and Methods We conducted a cross‐sectional observational study using a web‐based anonymous questionnaire from 22–26 April, 2020, among children (N = 2,292) in Spain. For children below 7 years of age, parents reported the children’s behavioural, emotional and somatic symptoms and family environment data on a questionnaire designed by the researchers. Children over 7 years answered the Revised Children’s Manifest Anxiety Scale either independently or with their parents’ assistance. Results Children over 7 years, boys in particular, scored high on the anxiety spectrum. Moreover, participants who knew someone who had suffered from COVID‐19 at home or whose parent was directly involved in the pandemic, obtained higher Total Anxiety scores. Significantly high values were found in all aspects of anxiety among those who feared infection or whose parents been unemployed. Of the children below 7 years, 56.3% had four or more anxiety‐related symptoms, the most frequent of which were tantrums, emotional changes, restlessness and fear of being alone. The number of symptoms reported was significant when someone in the family home had been infected with COVID‐19. Conclusions The COVID‐19 home confinement had a significant impact on children, causing anxiety, behavioural problems and somatic manifestations. Relevance to clinical practice Nurses play a key role in screening children who have experience confinement owing to the COVID‐19 pandemic in order to detect early anxiety symptoms using tele‐health. Suitable direct interventions can then be implemented or interdisciplinary manage could be started.
A systematic review of small sided games within rugby: Acute and chronic effects of constraints manipulation

ABSTRACT Small-sided games is a commonly used training method to develop technical, tactical and physical qualities concurrently. However, a review of small-sided games in rugby football codes (e.g. rugby union, rugby league) is not available. This systematic review aims to investigate the acute responses and chronic adaptations of small-sided games within rugby football codes considering the constraints applied. Four electronical databases were systematically searched until August 2020. Acute and chronic studies investigating rugby football codes small-sided games, with healthy amateur and professional athletes were included. Twenty studies were eventually included: 4 acute and 1 chronic in rugby union, 13 acute and 2 chronic in rugby league. Acute studies investigated task and individual constraints. Chronic studies showed that small-sided games would be an effective training method to improve physical performance. Current research in rugby football codes is heavily biased towards investigating how manipulating constraints can affect the physical characteristics of small-sided games, with limited literature investigating the effect on technical skills, and no studies investigating tactical behaviour. Future research is needed to evidence the effects of constraint manipulation on technical and tactical behaviour of rugby football players in small-sided games, in addition to physical characteristics.
Multilevel analysis of geographic variation among correlates of child undernutrition in India

Abstract Prior research has identified a number of risk factors ranging from inadequate household sanitation to maternal characteristics as important determinants of child malnutrition and health in India. What is less known is the extent to which these individual‐level risk factors are geographically distributed. Assessing the geographic distribution, especially at multiple levels, matters as it can inform where, and at what level, interventions should be targeted. The three levels of significance in the Indian context are villages, districts, and states. Thus, the purpose of this paper was to (a) examine what proportion of the variation in 21 risk factors is attributable to villages, districts, and states in India and (b) elucidate the specific states where these risk factors are clustered within India. Using the fourth National Family Health Survey dataset, from 2015 to 2016, we found that the proportion of variation attributable to villages ranged from 14% to 63%, 10% to 29% for districts and 17% to 62% for states. Furthermore, we found that Bihar, Jharkhand, Madhya Pradesh, and Uttar Pradesh were in the highest risk quintile for more than 10 of the risk factors included in our study. This is an indication of geographic clustering of risk factors. The risk factors that are clustered in states such as Bihar, Jharkhand, Madhya Pradesh and Uttar Pradesh underscore the need for policies and interventions that address a broader set of child malnutrition determinants beyond those that are nutrition specific.
Beliefs, Actions, and Rationality in Strategical Decisions

A puzzling finding from research on strategical decision making concerns the effect that predictions have on future actions. Simply stating a prediction about an opponent changes the total probability (pooled over predictions) of a player taking a future action compared to not stating any prediction. This is called an interference effect. We first review five different findings of interference effects from past empirical work using the prisoner's dilemma game. Then we report interference effects obtained from a new experiment in which 493 participants played a six-stage centipede game against a computer agent. During the first stage of the game, the total probability following prediction for cooperation was higher than making a decision alone; during later stages, the total probability following prediction for cooperation was lower than making a decision alone. These interference effects are difficult to explain using traditional economic models, and instead these results suggest turning to a quantum cognition approach to strategic decision making. Toward this end, we develop a belief-action entanglement model that provides a good account of the empirical results.
Assessment of the gut bacterial microbiome and metabolome of girls and women with Rett Syndrome

Background Gastrointestinal problems affect the health and quality of life of individuals with Rett syndrome (RTT) and pose a medical hardship for their caregivers. We hypothesized that the variability in the RTT phenotype contributes to the dysbiosis of the gut microbiome and metabolome in RTT, predisposing these individuals to gastrointestinal dysfunction. Objectives We characterized the gut bacterial microbiome and metabolome in girls and young women with RTT (n = 44) and unaffected controls (n = 21), and examined the relation between the composition of the microbiome and variations in the RTT phenotype. Methods Demographics and clinical information, including growth and anthropometric measurements, pubertal status, symptoms, clinical severity score, bowel movement, medication use, and dietary intakes were collected from the participants. Fecal samples were collected for analysis of the gut microbiome using Illumina MiSeq-based next-generation sequencing of the 16S rRNA gene followed by bioinformatics analysis of microbial composition, diversity, and community structure. Selected end-products of microbial protein metabolism were characterized by liquid chromatography-mass spectrometry. Results The gut bacterial microbiome differed within the RTT cohort based on pubertal status (p<0.02) and clinical severity scores (p<0.02) of the individuals and the type of diet (p<0.01) consumed. Although the composition of the gut microbiome did not differ between RTT and unaffected individuals, concentrations of protein end-products of the gut bacterial metabolome, including γ-aminobutyric acid (GABA) (p<0.001), tyrosine (p<0.02), and glutamate (p<0.06), were lower in the RTT cohort. Differences in the microbiome within RTT groups, based on symptomatic anxiety, hyperventilation, abdominal distention, or changes in stool frequency and consistency, were not detected. Conclusions Although variability in the RTT phenotype contributes to the dysbiosis of the gut microbiome, we presently cannot infer causality between gut bacterial dysbiosis and gastrointestinal dysfunction. Nevertheless, alterations in the gut metabolome may provide clues to the pathophysiology of gastrointestinal problems in RTT.
New Evidence for the Psychometric Properties of the Spanish Version of the Gain in Alzheimer Care Instrument

Abstract The aim was to analyze the psychometric properties of the Spanish version of the Gain in Alzheimer Care Instrument (GAIN), providing validity evidence based on its internal structure, reliability, item analysis, and relationships with other variables. A sample of 113 informal caregivers of people with dementia completed the GAIN, along with questionnaires assessing burden, general mental health, stress, anxiety, depression, and life satisfaction. Confirmatory factor analysis showed a single-factor structure with adequate fit indices. Reliability of GAIN scores was satisfactory, with McDonald’s omega equal to . 91. Items yielded adequate homogeneity indices. Validity evidence based on relationships with other variables was provided by positive correlations between GAIN scores and life satisfaction, and negative correlations with burden, general mental health problems, stress, anxiety, and depression. All these correlations were statistically significant, and most of them were of moderate magnitude. The Spanish version of the GAIN has a single-factor structure and satisfactory psychometric properties. It is quick and easy to apply and given the association between GAIN scores and other variables, it may be used to provide information about a caregiver’s psychological health status.