Miracle-dz/UniFAR-FTUs huggingface dataset:
Pupillary Light Response Deficits in 4-Week-Old Piglets and Adolescent Children after Low-Velocity Head Rotations and Sports-Related Concussions

Neurological disorders and traumatic brain injury (TBI) are among the leading causes of death and disability. The pupillary light reflex (PLR) is an emerging diagnostic tool for concussion in humans. We compared PLR obtained with a commercially available pupillometer in the 4 week old piglet model of the adolescent brain subject to rapid nonimpact head rotation (RNR), and in human adolescents with and without sports-related concussion (SRC). The 95% PLR reference ranges (RR, for maximum and minimum pupil diameter, latency, and average and peak constriction velocities) were established in healthy piglets (N = 13), and response reliability was validated in nine additional healthy piglets. PLR assessments were obtained in female piglets allocated to anesthetized sham (N = 10), single (sRNR, N = 13), and repeated (rRNR, N = 14) sagittal low-velocity RNR at pre-injury, as well as days 1, 4, and 7 post injury, and evaluated against RRs. In parallel, we established human PLR RRs in healthy adolescents (both sexes, N = 167) and compared healthy PLR to values obtained <28 days from a SRC (N = 177). In piglets, maximum and minimum diameter deficits were greater in rRNR than sRNR. Alterations peaked on day 1 post sRNR and rRNR, and remained altered at day 4 and 7. In SRC adolescents, the proportion of adolescents within the RR was significantly lower for maximum pupil diameter only (85.8%). We show that PLR deficits may persist in humans and piglets after low-velocity head rotations. Differences in timing of assessment after injury, developmental response to injury, and the number and magnitude of impacts may contribute to the differences observed between species. We conclude that PLR is a feasible, quantifiable involuntary physiological metric of neurological dysfunction in pigs, as well as humans. Healthy PLR porcine and human reference ranges established can be used for neurofunctional assessments after TBI or hypoxic exposures (e.g., stroke, apnea, or cardiac arrest).
Ammonia cores in high mass star formation regions

We observed a sample of 35 water masers not coincident with known HII regions and/or low mass young stellar objects (YSOs) with the Effelsberg 100 m telescope in the NH3(J,K) = (1,1), (2,2), (3,3) and (4,4) transitions. Sixteen sources were detected in the NH3 emission. The detection rate is 46%. All these sixteen sources have NH3 (1,1) and (2,2) emission, among which four sources have NH3 (3,3) emission. Comparing with the IRAS and the 2MASS data, we analyzed the relationship between the detection rate and the infrared color, the dust temperature and the source distance. All the detected sources were mapped and 17 cores were obtained (one source IRAS 20215+3725 has two cores). From the detected sources five cores do not coincide with radio continuum or IRAS and MSX point sources. Excluding one core that has no MSX data available, the remaining eleven cores are coincident with IRAS or MSX point sources. The typical size and mass of the cores are 1.6 pc and 1.5 x 10(3) M-circle dot, respectively. The average line widths of the NH3 (1,1) and (2,2) are 1.54 and 1.73 km s(-1). The average kinetic temperature of the gas is about 19 K. These values are much larger than those of low mass cores. The NH3 cores that coincide with IRAS sources (referred to as Group I) have slightly larger line widths (1.65 and 1.75 km s(-1) for the (1,1) and (2,2) lines, respectively) and larger masses (1.8 x 10(3) M-circle dot) than the mean values of the sample. For this type of core the kinetic temperature correlates with the line width. The line width appears to correlate with the bolometric luminosity and the core size. Despite the average luminosity of 2.9 x 10(4) L-circle dot, there is no detectable 6 cm emission. These are candidates for high mass protostars or precursors of UC HII regions. The NH3 cores with peaks onset from infrared sources (referred to as Group II) have an average size of 1.7 pc and an average line width of 1.50 km s(-1) for the (1,1) line. The line width of the (1,1) emission is smaller than that of the group I. The average mass is 9.4 x 10(2) M-circle dot. One possible explanation for the deviation is that the NH3 peak and the infrared source correspond to different clumps. These cores are potential high mass star formation sites and may be at an earlier evolutionary stage than those with IRAS point sources. This type of core is seen in mapping observations, and can be easily missed by single-spectrum observations toward the IRAS position.
Skeletonization of ribbon-like shapes with new wavelet function

In this paper we propose a new scheme to extract the skeleton of ribbon-like shape with a novel wavelet function. It consists of two phases based on these perfect properties of the new wavelet function; and symmetry analyses of maxima moduli of wavelet transform are given. Midpoints of all pairs of contour elements are connected to generate a skeleton of the shape, which is defined as wavelet skeleton. Four basic criteria for modifying the artifacts of wavelet skeleton are presented. A corresponding algorithm is developed, and the experimental results are shown that this algorithm is capable of extracting exactly the skeleton of ribbon-like shape with different widths as well as different grey-levels.
Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series

Polycythemia vera (PV) and non-cirrhotic portal hypertension (NCPH) are relatively independent diseases, and few studies have linked them. However, in clinical settings, there may be a causal relationship. The aim of the present study was to analyze the clinical data of five patients with portal hypertension caused by PV and summarize the characteristics of PV with portal hypertension, to enhance the knowledge of this disease. The clinical data of five patients with PV and portal hypertension treated at Beijing You'an Hospital (Beijing, China) from January 2010 to March 2022 were retrospectively collected. The characteristics of these patients were then summarized and analyzed, including general information, laboratory tests, imaging and gastroscopy data. Overall, four patients were diagnosed with PV earlier compared with those with NCPH (ranging between days and years), whereas one patient was diagnosed with NCPH at the time of PV diagnosis. These four patients had blood cell elevations of 2-3 categories (red blood cells, white blood cells or platelets). The Child classification of liver functions in all five patients were found to be grades A-B. All five patients had splenomegaly, where three patients had portal vein thrombosis and cavernous degeneration. In addition, four patients had moderate or severe esophageal varices. In conclusion, to the best of our knowledge, this was the first case series of NCPH caused by PV. Among the patients, it was revealed that: i) NCPH caused by PV had milder liver function damage compared with cirrhosis-induced portal hypertension; ii) splenomegaly, ascites and esophageal varicose veins were prominent symptoms of NCPH caused by PV; iii) If PV is diagnosed, esophagogastroduodenoscopy should be performed as early as possible and regularly, where primary prevention measures for esophageal variceal hemorrhage are recommended; and iv) patients with PV with portal hypertension are at risk of thrombosis and bleeding, but it remains to be determined whether early antithrombotic therapy can reduce complications.
Design, Synthesis, and Characterization of Novel Bis-Uracil Chitosan Hydrogels Modified with Zinc Oxide Nanoparticles for Boosting Their Antimicrobial Activity

A new series of hydrogels was successfully prepared by incorporating various substituted bisuracil (R-BU) linkages between chitosan Schiff’s base chains (R-BU-CsSB) and between chitosan chains (R-BU-Cs). After protection of the amino groups of chitosan by benzaldehyde, yielding chitosan Schiff’s base (CsSB), the reaction with epichlorohydrin was confined on the -OH on C6 to produce epoxy chitosan Schiff’s base (ECsSB), which was reacted with R-BU to form R-BU-CsSB hydrogels, and finally, the bioactive amino groups of chitosan were restored to obtain R-BU-Cs hydrogels. Further, some R-BU-Cs-based ZnO nanoparticle (R-BU-Cs/ZnONPs) composites were also prepared. Appropriate techniques such as elemental analysis, FTIR, XRD, SEM, and EDX were used to verify their structures. Their inhibition potency against all the tested microbes were arranged as: ZnONPs bio-composites > R-BU-Cs hydrogels > R-BU-CsSB hydrogels > Cs. Their inhibition performance against Gram-positive bacteria was better than Gram-negative ones. Their minimum inhibitory concentration (MIC) values decreased as a function of the negative resonance effect of the substituents in the aryl ring of R-BU linkages in the hydrogels. Compared with Vancomycin, the ZnONPs bio-composites showed superior inhibitory effects against most of the tested Gram-negative bacteria, all inspected Gram-positive ones, and all investigated fungi.
Hierarchical Reasoning versus Iterated Reasoning in p-Beauty Contest Guessing Games

This paper analyzes strategic choice in p-beauty contests. We first show that it is not generally a best reply to guess the expected target value (accounting for the own weight) even in games with n>2 players and that iterated best response sequences are not unique even after perfect/cautious refinement. This implies that standard formulations of ``level-k'' models are neither exactly nor uniquely rationalizable by belief systems based on iterated best response. Second, exact modeling of iterated reasoning weakens the fit considerably and reveals that equilibrium types dominate the populations. We also show that ``levels of reasoning'' cannot be measured regardless of the underlying model. Third, we consider a ``nested logit'' model where players choose their level. It dispenses with belief systems between players and is rationalized by a random utility model. Besides being internally consistent, nested logit equilibrium fits better than three variants of the level-k model in standard data sets.
Evidence for fireballs in bipolar HiPIMS plasmas

Using laser Thomson scattering (LTS) and 2D optical imaging, a fireball-like discharge is detected during the positive pulse period of bipolar voltage waveforms, for a circular planar unbalanced magnetron with W target operating in argon. These reverse discharges, excited for positive pulse voltages V pp from 200 to 300 V, sit primarily on the discharge centreline. Their establishment is delayed relative to the initiation of the positive pulse, with the delay time shortening with increased V pp: they are clearly attached to the target (anode in this phase) and have lifetimes extending to the end of the positive pulse. LTS measurements of the electron temperature T e show dramatic electron heating (T e rises from 1 up to 3 eV) both on the discharge centre line and above the racetrack during the fireball event. This is consistent with greater light intensities from the broad band optical imaging of the discharge. In the fireball phase, the LTS measurements also show greatly reduced election densities (by a factor of 5) in the magnetic trap (directly above the racetrack) compared to the unipolar pulse case. The existence of such anodic fireballs is quite possibly an unwanted effect in bipolar HiPIMS.
A connection between uniformity and aberration in regular fractions of two-level factorials

We show a link between the two apparently unrelated areas of uniformity and minimum aberration. With reference to regular fractions of two-level factorials, we derive an expression for the centred L 2 -discrepancy measure for uniformity in terms of the word-length pattern. This result indicates, in particular, excellent behaviour of minimum aberration designs with regard to uniformity and provides further justification for the popular criterion of minimum aberration.
Robustness bounds for LQ regulators

A robustification procedure for LQ state feedback design is presented. Such a procedure consists of choosing the state and input weighting matrices according to the kind of uncertainties on the system. Both structured and norm-bounded additive uncertainties are addressed, and upper bounds for the uncertainties that do not destabilize the closed-loop system are presented. Connections with the quadratic stabilizability problem are established. >
On the Anomaly Tilts of Factor Funds

By analyzing portfolio holdings, we find that a significant subset of Hedged Mutual Funds (HMFs) and smart-beta Exchange-Traded Funds (ETFs) tilt their portfolios towards well-known anomaly characteristics and that such tilts are highly persistent. Short positions of HMFs amplify their factor tilts. Most “single-factor” ETFs actually target multiple factors, while many also exhibit offsetting tilts to other factors. HMFs with large factor tilts outperform corresponding ETFs, which is driven by short positions and higher factor-related returns. Overall, we show the superior factor replication ability of HMFs over ETFs, and that HMFs achieve similar performance as the academic factors. JEL Classification: G10, G11, G14, G23
Working Posture and the Center of Mass Assessment While Starting a Chainsaw: A Case Study among Forestry Workers in Croatia

Motor-manual work with a chainsaw is still an irreplaceable occupational activity in forest harvesting operations in Croatia and in many other countries. Chainsaw workers are exposed to different risk factors, such as noise and vibrations, heavy load lifting, awkward and preflexion postures, repetitive movements, etc. The working posture and the assessment of the center of mass plays an important role in understanding the exposure of forest workers to postural and occupational risks, either as a part of the entire work process or as a part of an individual element of the work technique. Therefore, the aim of this research was to investigate the impact of three different chainsaw starting methods (from the ground, between the knees, and “drop starting”) on the postural load of the chainsaw worker and its association with personal and occupational factors. The field portion of data collection was conducted in the second and third quarters of 2022. For trunk posture assessment (n = 74), the rapid entire body assessment (REBA) tool was used, and for the center of mass measurement (n = 28), the Xsens MVN Link motion capture suit was used, a relatively new technology that allows data collection in real field conditions. Descriptive and inferential statistical methods were used to verify and analyze the field data. Based on the obtained results, almost 50% of the sampled chainsaw workers ignored safety instructions and preferred “drop starting” a chainsaw. The results also showed that there is a significant difference between the three starting methods in the REBA score, as well as in the number of segments scored during the assessment. The obtained mean REBA score for all three methods is between 4 and 7, placing all methods at a medium level of MSD risk. Regarding the analysis of the Center of Mass (CoM) vertical deviation, the statistical difference is noticeable for the body mass index (BMI) group, the group related to experience with the chainsaw, and the age and height group in relation to three methods for starting a chainsaw. The safest method, which implies starting a chainsaw from the ground, resulted also as the riskiest in terms of postural strain, which, cumulatively over the time variable, can contribute to health problems in forest workers. In conclusion, related to the future process of professional training development for chainsaw workers, an integral part of the training must contain the most optimal postural-movement habits that need to be defined by further kinematic research in forestry.
Determinants and Assembly Mechanism of Bacterial Community Structure in Ningxia Section of the Yellow River

The Yellow River is a valuable resource in the Ningxia Hui Autonomous Region and plays a vital role in local human activities and biodiversity. Bacteria are a crucial component of river ecosystems, but the driving factors and assembly mechanisms of bacterial community structure in this region remain unclear. Herein, we documented the bacterial community composition, determinants, co-occurrence pattern, and assembly mechanism for surface water and sediment. In comparison to sediment, the bacterioplankton community showed significant seasonal variation, as well as less diversity and abundance. The network topology parameters indicated that the sediment bacterial network was more stable than water, but the bacterioplankton network had higher connectivity. In this lotic ecosystem, CODMn, Chl a, and pH affected the structure of the bacterioplankton community, while TP was the primary factor influencing the structure of the sediment bacterial community. The combined results of the neutral community model and the phylogenetic null model indicate that Bacterial communities in both habitats were mainly affected by stochastic processes, with ecological processes dominated by ecological drift for bacterioplankton and dispersal limitation for sediment bacteria. These results provide essential insights into future research on microbial ecology, environmental monitoring, and classified management in the Ningxia section of the Yellow River.
Sustained and Targeted Delivery of Self-Assembled Doxorubicin Nonapeptides Using pH-Responsive Hydrogels for Osteosarcoma Chemotherapy

While chemotherapeutic agents have particularly potent effects in many types of cancer, their clinical applications are still far from satisfactory due to off-target drug exposure, chemotherapy resistance, and adverse effects, especially in osteosarcoma. Therefore, it is clinically promising to construct a novel tumor-targeted drug delivery system to control drug release and alleviate side effects. In this study, a pH-responsive nonapeptide hydrogel was designed and fabricated for the tumor-targeted drug delivery of doxorubicin (DOX). Using a solid-phase synthesis method, a nonapeptide named P1 peptide that is structurally akin to surfactant-like peptides (SLPs) due to its hydrophobic tail and hydrophilic head was synthesized. The physicochemical properties of the P1 hydrogel were characterized via encapsulation capacity, transmission electron microscopy (TEM), circular dichroism (CD), zeta potential, rheological analysis, and drug release studies. We also used in vitro and in vivo experiments to investigate the cytocompatibility and tumor inhibitory efficacy of the drug-loaded peptide hydrogel. The P1 peptide could self-assemble into biodegradable hydrogels under neutral conditions, and the prepared drug-loaded hydrogels exhibited good injectability and biocompatibility. The in vitro drug release studies showed that DOX-P1 hydrogels had high sensitivity to acidic conditions (pH 5.8 versus 7.4, up to 3.6-fold). Furthermore, the in vivo experiments demonstrated that the DOX-P1 hydrogel could not only amplify the therapeutic effect but also increase DOX accumulation at the tumor site. Our study proposes a promising approach to designing a pH-responsive hydrogel with controlled doxorubicin-release action based on self-assembled nonapeptides for targeted chemotherapy.
Expression of the Calcitonin Receptor-like Receptor (CALCRL) in Normal and Neoplastic Tissues

Little information is available concerning protein expression of the calcitonin receptor-like receptor (CALCRL) at the protein level. Here, we developed a rabbit monoclonal antibody, 8H9L8, which is directed against human CALCRL but cross-reacts with the rat and mouse forms of the receptor. We confirmed antibody specificity via Western blot analyses and immunocytochemistry using the CALCRL-expressing neuroendocrine tumour cell line BON-1 and a CALCRL-specific small interfering RNA (siRNA). We then used the antibody for immunohistochemical analyses of various formalin-fixed, paraffin-embedded specimens of normal and neoplastic tissues. In nearly all tissue specimens examined, CALCRL expression was detected in the capillary endothelium, smooth muscles of the arterioles and arteries, and immune cells. Analyses of normal human, rat, and mouse tissues revealed that CALCRL was primarily present in distinct cell populations in the cerebral cortex; pituitary; dorsal root ganglia; epithelia, muscles, and glands of the larger bronchi; intestinal mucosa (particularly in enteroendocrine cells); intestinal ganglia; exocrine and endocrine pancreas; arteries, capillaries, and glomerular capillary loops in the kidneys; the adrenals; Leydig cells in the testicles; and syncytiotrophoblasts in the placenta. In the neoplastic tissues, CALCRL was predominantly expressed in thyroid carcinomas, parathyroid adenomas, small-cell lung cancers, large-cell neuroendocrine carcinomas of the lung, pancreatic neuroendocrine neoplasms, renal clear-cell carcinomas, pheochromocytomas, lymphomas, and melanomas. In these tumours with strong expression of CALCRL, the receptor may represent a useful target structure for future therapies.
Qualitative properties of modified equations

Suppose that a consistent one-step numerical method of order r is applied to a smooth system of ordinary differential equations. Given any integer m ⩾ 1, the method may be shown to be of order r + m as an approximation to a certain modified equation. If the method and the system have a particular qualitative property then it is important to determine whether the modified equations inherit this property. In this article, a technique is introduced for proving that the modified equations inherit qualitative properties from the method and the underlying system. The technique uses a straightforward contradiction argument applicable to arbitrary one-step methods and does not rely on the detailed structure of associated power series expansions. Hence the conclusions apply, but are not restricted, to the case of Runge-Kutte methods. The new approach unifies and extends results of this type that have been derived by other means: results are presented for integral preservation, reversibility, inheritance of fixed points. Hamiltonian problems and volume preservation. The technique also applies when the system has an integral that the method preserves not exactly, but to order greater than r. Finally, a negative result is obtained by considering a gradient system and gradient numerical method possessing a global property that is not shared by the associated modified equations.
Online teaching and learning in physical education teacher education: A mixed studies review of literature

Delivering physical education teacher education (PETE) programmes through online platforms has been proposed as an alternative (or complementary) to traditional in-person modes of learning. Focusing on empirical studies, this mixed studies review explores the use of online teaching and learning in PETE and synthesises literature published between 2010 and 2020. Fourteen studies met the inclusion criteria. A data-based convergent synthesis design is adopted. Pedagogies and technologies commonly used are examined. Studies using a blended approach to teaching and learning provide more detail about the pedagogies and technologies used than those studies using a fully online model. There is scant information regarding the principles underpinning the development and delivery of online PETE courses. We provide extensive insights into the key learning from the experiences of faculty and pre-service teachers who engage with online teaching and learning in PETE. Our findings suggest online instruction may suit particular students and facilitate a shift to independent learning. Teaching and learning in the online space can impact the development of relationships, both positively and negatively. Furthermore, constructivist pedagogies should be prioritised, alongside support for students and teacher educators to develop online learning competence. Our review highlights considerations for teacher educators engaging in online teaching and learning in PETE and implications for future research.