Miracle-dz/UniFAR-FTUs huggingface dataset:
Frontotemporal Lobar Degeneration Case with an N-Terminal TUBA4A Mutation Exhibits Reduced TUBA4A Levels in the Brain and TDP-43 Pathology

Recently, disease-associated variants of the TUBA4A gene were identified in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we present the neuropathological report of a patient with the semantic variant of primary progressive aphasia with a family history of Parkinsonism, harboring a novel frameshift mutation c.187del (p.Arg64Glyfs*90) in TUBA4A. Immunohistochemistry showed abundant TAR DNA-binding protein 43 kDa (TDP-43) dystrophic neurite pathology in the frontal and temporal cortex and the dentate gyrus of the hippocampus, consistent with frontotemporal lobar degeneration (FTLD). The observed pathology pattern fitted best with that of FTLD-TDP Type C. qPCR showed the presence of mutant TUBA4A mRNA. However, no truncated TUBA4A was detected at the protein level. A decrease in total TUBA4A mRNA and protein levels suggests loss-of-function as a potential pathogenic mechanism. This report strengthens the idea that N-terminal TUBA4A mutations are associated with FTLD-TDP. These N-terminal mutations possibly exert their pathogenic effects through haploinsufficiency, contrary to C-terminal TUBA4A mutations which are thought to disturb the microtubule network via a dominant-negative mechanism.
Heterozygosity, genetic similarity and extra‐pair paternity variation in two populations of rock sparrow
 Petronia petronia
 : a within and between populations comparison

tarsus size, body weight or yellow badge size, suggesting that females were not choosing extra-pair partners based on heterozygosity, genetic similarity or phenotypic quality. Although based on a limited sample in the within population analysis, our results indicate that EPP may evolve in response to a low level of genetic variability in the population.
Development of the Trauma-Informed Practice Scales – Supervision Version (TIPS-SV)

ABSTRACT Using item response theory, we examined the psychometric properties of scores on the Trauma-Informed Practice Scales – Supervision Version (TIPS-SV) – a unidimensional measure of supervisees’ perceptions of their supervisors’ adherence to trauma-informed supervision – in a sample of 312 supervisees. Implications for research and supervision practice are discussed.
R-Spondin2, a Positive Canonical WNT Signaling Regulator, Controls the Expansion and Differentiation of Distal Lung Epithelial Stem/Progenitor Cells in Mice

The lungs have a remarkable ability to regenerate damaged tissues caused by acute injury. Many lung diseases, especially chronic lung diseases, are associated with a reduced or disrupted regeneration potential of the lungs. Therefore, understanding the underlying mechanisms of the regenerative capacity of the lungs offers the potential to identify novel therapeutic targets for these diseases. R-spondin2, a co-activator of WNT/β-catenin signaling, plays an important role in embryonic murine lung development. However, the role of Rspo2 in adult lung homeostasis and regeneration remains unknown. The aim of this study is to determine Rspo2 function in distal lung stem/progenitor cells and adult lung regeneration. In this study, we found that robust Rspo2 expression was detected in different epithelial cells, including airway club cells and alveolar type 2 (AT2) cells in the adult lungs. However, Rspo2 expression significantly decreased during the first week after naphthalene-induced airway injury and was restored by day 14 post-injury. In ex vivo 3D organoid culture, recombinant RSPO2 promoted the colony formation and differentiation of both club and AT2 cells through the activation of canonical WNT signaling. In contrast, Rspo2 ablation in club and AT2 cells significantly disrupted their expansion capacity in the ex vivo 3D organoid culture. Furthermore, mice lacking Rspo2 showed significant defects in airway regeneration after naphthalene-induced injury. Our results strongly suggest that RSPO2 plays a key role in the adult lung epithelial stem/progenitor cells during homeostasis and regeneration, and therefore, it may be a potential therapeutic target for chronic lung diseases with reduced regenerative capability.
Augmenting the Tolerance Potential of  Muskmelon (Cucumis melo L.) Using Salicylic Acid

Salicylic acid (SA) is considered an important plant hormone that controls many aspects of plant growth and development, as well as resistance to biotic and abiotic stresses. In current investigations, a pot experiment consisting of four different levels of SA (0, 1, 2 and 3 mM SA) were tested on growth and physiological attributes of muskmelon (Cucumis melo L.), grown at different salinity levels (0, 50, 100 mM NaCl). Results revealed that all the morphological and physiological attributes were significantly (P<0.05) adversely affected by salinity stress, whereas application of SA improved growth rate of muskmelon both in saline and non-saline conditions. SA treated plants showed higher total chlorophyll content, photosynthetic rate and stomatal regulations as compared to control plants. SA application reduced the salt deleterious effects by inhibiting toxic Na+ ions accumulation in leaf and increased K+/Na+ ratio. Among the various applied concentrations, 2 mM SA increased shoot fresh weight by (30%), dry weight (34%), leaf area (25%) and K+/Na+ ratio by (84%) as compared to control plants. Thus, 2 mM SA concentration is concluded to be the best ameliorative treatment in salt stressed environments to enhance the muskmelon production.
Dynamic Graphical Instructions Result in Improved Attitudes and Decreased Task Completion Time in Human–Robot Co-Working: An Experimental Manufacturing Study

Collaborative robots offer opportunities to increase the sustainability of work and workforces by increasing productivity, quality, and efficiency, whilst removing workers from hazardous, repetitive, and strenuous tasks. They also offer opportunities for increasing accessibility to work, supporting those who may otherwise be disadvantaged through age, ability, gender, or other characteristics. However, to maximise the benefits, employers must overcome negative attitudes toward, and a lack of confidence in, the technology, and must take steps to reduce errors arising from misuse. This study explores how dynamic graphical signage could be employed to address these issues in a manufacturing task. Forty employees from one UK manufacturing company participated in a field experiment to complete a precision pick-and-place task working in conjunction with a collaborative robotic arm. Twenty-one participants completed the task with the support of dynamic graphical signage that provided information about the robot and the activity, while the rest completed the same task with no signage. The presence of the signage improved the completion time of the task as well as reducing negative attitudes towards the robots. Furthermore, participants provided with no signage had worse outcome expectancies as a function of their response time. Our results indicate that the provision of instructional information conveyed through appropriate graphical signage can improve task efficiency and user wellbeing, contributing to greater workforce sustainability. The findings will be of interest for companies introducing collaborative robots as well as those wanting to improve their workforce wellbeing and technology acceptance.
Enotourism in Southern Spain: The Montilla-Moriles PDO

The profile of tourists during the COVID-19 pandemic is changing toward those seeking health, safety and quality products. One of the modalities that best adapts to these needs is gastronomic tourism and, within this segment, wine tourism (enotourism), which can be enjoyed in many areas across the world. The great diversity of grapes, climates, terrains and winemaking processes gives rise to an enormous variety of wines that ensures that no two wines are alike. The current situation of the tourism market necessitates enhancing the uniqueness of areas that offer differentiated products, helping to position such locations as benchmarks for gastronomic tourism. Gastronomic routes provide a way to unify and benefit rural areas through the recently increased demand of tourists seeking to experience regional foods. In this study, the Montilla-Moriles Wine Route is analyzed with the objective of forecasting the demand (using autoregressive integrate moving average, ARIMA models), establishing a tourist profile and calculating the probability that a wine tourist is satisfied with the visit based on their personal characteristics (logit model). The results obtained indicate a slight increase (3.6%) in wine tourists with a high degree of satisfaction, primarily derived from the gastronomic or catering services of the area, from the number of wineries visited, from the treatment received and from the age of the tourist. Consequently, a high percentage of these tourists recommend the route. By increasing the demand for enotourism in this area and applying the results obtained, marketing initiatives could be established, particularly for wine festivals to improve this tourist segment and generate wealth in that area.
The Role of Perceived Social Support and Stress in the Relationship between Hope and Depression among Chinese Shadow Education Tutors: A Serial Mediation Model

The association between hope and depression has been studied, leaving the underlying mechanism of how hope might predict depression unexplored. With a cross-sectional design, this study investigated two possible mediating factors in the relationship between hope and depression among Chinese shadow education tutors, who confront a high turnover rate and are at high risk for depression. Altogether, 221 tutors participated in the survey, and reported their dispositional hope, perceived social support (PSS), perceived stress (PS), and depression. Results indicated that both PSS and PS mediated the relationship between hope and depression. Results also supported the hypothesized serial mediating effect. In other words, hope as a positive disposition may promote PSS, which can mitigate PS. The reduced PS, in turn, alleviates depression. This finding not only shed light on the independent and accumulative mediating effects of PSS and PS, but also has implications for preventive interventions among Chinese shadow education tutors experiencing the enormous pressure of instability. This serial mediation model should be confirmed by further longitudinal study.
Entanglement of Spin-Pair Qubits with Intrinsic Dephasing Times Exceeding a Minute

Understanding and protecting the coherence of individual quantum systems is a central challenge in quantum science and technology. Over the last decades, a rich variety of methods to extend coherence have been developed. A complementary approach is to look for naturally occurring systems that are inherently protected against decoherence. Here, we show that pairs of identical nuclear spins in solids form intrinsically long-lived quantum systems. We study three carbon-13 pairs in diamond and realize high-fidelity measurements of their quantum states using a single NV center in their vicinity. We then reveal that the spin pairs are robust to external perturbations due to a unique combination of three phenomena: a clock transition, a decoherence-free subspace, and a variant on motional narrowing. The resulting inhomogeneous dephasing time is $T_2^* = 1.9(3)$ minutes, the longest reported for individually controlled qubits. Finally, we develop complete control and realize an entangled state between two spin-pair qubits through projective parity measurements. These long-lived qubits are abundantly present in diamond and other solids, and provide new opportunities for quantum sensing, quantum information processing, and quantum networks.
Monitored and Modeled Ambient Air Concentrations of Ethylene Oxide: Contextualizing Health Risk for Potentially Exposed Populations in Georgia

Recent studies have monitored and modeled long-term ambient air concentrations of ethylene oxide (EO) around emitting facilities in Georgia with the intent of informing risk management of potentially exposed nearby residential populations. Providing health context for these data is challenging because the U.S. Environmental Protection Agency’s risk-specific concentrations lack practical utility in distinguishing a health significant increase in exposure. This study analyzes EO data for eight emitting facilities, using a previously published alternative exposure metric, the total equivalent concentration, which is based on U.S. Centers for Disease Control biomarker data for the non-smoking U.S. population. Mean concentrations for monitoring sites were compared to mean background concentrations to assess whether emissions contribute significantly to environmental concentrations. To assess the health significance of potential exposure at nearby residential locations, the 50th percentile concentration was added to the 50th percentile endogenous equivalent concentration and compared to the total equivalent concentration distribution for the non-smoking U.S. population. The findings demonstrate that impacts from nearby emission sources are small compared to mean background concentrations at nearby locations, and the total equivalent concentrations for exposed populations are generally indistinguishable from that of the 50th percentile for the non-smoking U.S. population.
Novel Adaptive Dynamic Event-Triggered Bipartite Consensus Protocols with Intermittent Updating and Interaction

This paper addresses the distributed bipartite consensus control problem faced with some intricate demands, namely, discrete-time control updating for each agent, intermittent interaction among neighbors, and the fully distributed fashion of the protocol design requiring no global information of the network topology. Given that no existing results meet all the three essential demands, we in this paper establish a unified framework on fully distributed adaptive bipartite consensus control with intermittent updating and interaction. The core is a novel dynamic triggering function decoupled with the network topology, based on which a discretely updated controller for each agent is designed accordingly. Then, adaptive dynamic eventtriggered protocols can be modularly designed with the twocomponent framework. Finally, a numerical example is provided to verify the effectiveness of the presented protocols.
Production of Chicken Patties Supplemented with Cantaloupe By-Products: Impact on the Quality, Storage Stability, and Antioxidant Activity

This study investigated the effect of supplementation with cantaloupe peel (CP) and seeds (CS) (3, 6, 9, and 12%) powder on the quality and antioxidant activity of raw and cooked chicken patties during storage (-20°C/3 months). The addition of CP and CS powder increased protein, fat, ash, and fiber values of chicken patties compared with control, while carbohydrate, pH, and TBA were decreased at zero time and after 3 months of storage. The WHC, cooking yield, fat retention, and moisture retention were increased by increasing CP and CS powder addition ratios, while cooking loss and shrinkage were decreased. Also, CP and CS powder improved antioxidant activity, microbiological quality, and overall acceptability of chicken patties. The hardness of raw and cooked chicken patties was decreased with increasing CP and CS addition ratios. It is recommended to use CP and CS powder as functional ingredients in the preparation of functional foods.
Adaptive Retrofit for Adaptive Reuse: Converting an Industrial Chimney into a Ventilation Duct to Improve Internal Comfort in a Historic Environment

The reuse of architectural heritage is a topic of great interest for scientific research, involving aspects ranging from the architectural compatibility of the interventions to the performance updating of the artefacts, from the point of view of both energy consumption and internal comfort suitable for the new use. Compatible technological solutions exploit the passive cooling activating latent physical mechanisms of the building, of the envelope or its parts, such as openings and disused shafts. This work concerns the conversion of an old chimney, completely integrated into the historical envelope, into a ventilation duct for the air exchange and the internal comfort improvement of an old factory, proposing an adaptive retrofit solution during adaptive reuse intervention. Thermo-fluid dynamics analyses, performed with an ad hoc CFD solver for flows with flotation effects, verified the effective functionality of the device in summer and winter conditions. The results show that, in summer, the activation of passive ventilation improves the indoor comfort of the environment, while, in winter, it worsens them. This study demonstrates the usefulness of activating passive cooling phenomena in preserving historical architecture. Finally, the future potential of the application is presented by integrating the ventilation chimney with a mechanical control system to optimize its operation even in winter conditions.
Hydrodynamic loading of wave return walls on top of seaside promenades

To reduce coastal flooding risks in several coastal towns in Belgium wave return walls on top of the existing seaside promenades are designed. The structural strength and foundation of the wave return walls have to be designed taking into account the hydrodynamic loading due to overtopping waves. Based on existing relations for layer thickness and layer speed of overtopping waves a semiempirical formula is developed to deliver a design value for the hydrodynamic loading on a wave return wall for given geometric and hydraulic boundary conditions. Using experimental results of scale models in wave flumes the empirical parameters of the semi-empirical formula are to be calibrated and validated for the range of applicability representative for the configurations occurring along the Belgian coastline.
The educational performance of immigrant children: Examination of the native-immigrant education gap

Why is there a native-immigrant education gap in Denmark? And has the gap been reduced over time? This article adds to existing research by examining the explanations behind the existence of the education gap and the development in the gap across time. The education gap is examined by comparing upper secondary completion rates for children graduating from compulsory school between 1990 and 2007. The education production function is estimated as a linear probability model with OLS. The article finds that the gap has narrowed significantly over the past 20 years and that differences in family background explain a large part of the gap. Furthermore, a strong relation between the child’s age at arrival and educational performance is found.
Caffeinated beverage consumption among adolescents in Sagamu, Nigeria: implications for health promotion

Introduction the mental and physical stimulating effects of caffeine have led to an increase in consumption of caffeinated beverages. Adolescents are at an increased risk of excessive caffeine consumption and its associated adverse health consequences. This study therefore assessed the pattern of caffeinated drink consumption among in-school adolescents in Sagamu, Ogun State, Nigeria. Methods a descriptive, cross-sectional study was carried out among 350 adolescents in Sagamu Township, selected via multistage sampling. Data were collected using a semi-structured self-administered questionnaire and analyzed with SPSS version 20.0. Relevant descriptive and inferential statistics were calculated with level of significance (p) set at <0.05. Results respondents' mean age was 14.49 ± 1.37 years; 60.2% of respondents were male. Over 90% of respondents consumed caffeinated beverages; 19.2% consumed greater than 3 cans in a day; 67.8% always felt a strong urge to consume caffeinated drinks. Reasons for consumption include: to aid personal study (64.4%), thirst (47.1%), performance enhancement (34.1%), alertness (30.6%) and hunger (17.7%). Reported side effects include: nervousness (40.4%); mood swings (16.5%); palpitations (30.1%); insomnia (51.6%). Conclusion consumption of caffeinated beverages was high among adolescents in Sagamu. Adequate caffeine control measures, with behavior change communication, will help to address this public health challenge among adolescents.
Asbestos Exposure in Patients with Malignant Pleural Mesothelioma included in the PRIMATE Study, Lombardy, Italy

The PRIMATE study is an Italian translational research project, which aims to identify personalized biomarkers associated with clinical characteristics of malignant pleural mesothelioma (MPM). For this purpose, characteristics of MPM patients with different degrees of asbestos exposure will be compared to identify somatic mutations, germline polymorphism, and blood inflammatory biomarkers. In this framework, we assessed exposure to asbestos for 562 cases of MPM extracted from the Lombardy region Mesothelioma Registry (RML), for which a complete interview based on a standardized national questionnaire and histopathological specimens were available. Exposure assessment was performed: (1) through experts' evaluation (considered as the gold standard for the purpose of this study), according to the guidelines of the Italian National Mesothelioma Registry (ReNaM) and (2) using a job-exposure matrix (SYN-JEM) to obtain qualitative (ever/never) and quantitative estimates of occupational asbestos exposure (cumulative exposure expressed in fibers per mL (f/mL)). The performance of SYN-JEM was evaluated against the experts' evaluation. According to experts' evaluation, occupational asbestos exposure was recognized in 73.6% of men and 23.6% of women; furthermore, 29 men (7.8%) and 70 women (36.9%) had non-occupational exposure to asbestos. When applying SYN-JEM, 225 men (60.5%) and 25 women (13.2%) were classified as occupationally exposed, with a median cumulative exposure higher for men (1.7 f/mL-years) than for women (1.2 f/mL-years). The concordance between the two methods (Cohen’s kappa) for occupational exposure assessment was 0.46 overall (0.41 in men, and 0.07 in women). Sensitivity was higher in men (0.73) than in women (0.18), while specificity was higher in women (0.88) than in men (0.74). Overall, both methods can be used to reconstruct past occupational exposure to asbestos, each with its own advantages and limitations.