Miracle-dz/UniFAR-FTUs huggingface dataset:
Magneto-Luminescent Nanocomposites Based on Carbon Dots and Ferrite with Potential for Bioapplication

Multifunctional nanocomposites that combine both magnetic and photoluminescent (PL) properties provide significant advantages for nanomedical applications. In this work, a one-stage synthesis of magneto-luminescent nanocomposites (MLNC) with subsequent stabilization is proposed. Microwave synthesis of magnetic carbon dots (M-CDs) was carried out using precursors of carbon dots and magnetic nanoparticles. The effect of stabilization on the morphological and optical properties of nanocomposites has been evaluated. Both types of nanocomposites demonstrate magnetic and PL properties simultaneously. The resulting MLNCs demonstrated excellent solubility in water, tunable PL with a quantum yield of up to 28%, high photostability, and good cytocompatibility. Meanwhile, confocal fluorescence imaging showed that M-CDs were localized in the cell nuclei. Consequently, the multifunctional nanocomposites M-CDs are promising candidates for bioimaging and therapy.
Comparison of Losartan and Furosemide Interaction with HSA and Their Influence on HSA Antioxidant Potential

Serum albumin (HSA) is the most important protein in human body. Due to the antioxidant activity, HSA influences homeostasis maintenance and transport of drugs as well as other substances. It is noteworthy that ligands, such as popular drugs, modulate the antioxidant activity of HSA. The aim of this study was to analyze the influence of losartan (LOS) and furosemide (FUR) on HSA antioxidant properties as well as the interaction between these drugs and protein using calorimetric and spectroscopic methods. LOS and FUR showed the high affinity for human serum albumin, and the binding reactions between them were spontaneous and exothermic. LOS and FUR, separately and together in the system, have no significant impact on the secondary HSA structure; however they have significant impact on the tertiary HSA structure. LOS and FUR mixed with HSA have the ability to scavenge free radicals, and the ligand(s)–HSA interactions were synergistic.
AC 2011-1399: SOLVING THE ENGINEERING PIPELINE CHALLENGE

A comprehensive analysis of our engineering student retention and graduation rates for first time freshmen in a School of Engineering major quantified a compelling need for enhancing early (freshmen and sophomore) retention rates and graduation rates. A Summer Engineering Enrichment Program (SEEP) was initiated in 2009 and early indications from the first two cohorts indicate success [1]. Those analyses and early indications of SEEP success led to the realization that a relatively near term solution to our highly publicized and well documented United States engineering pipeline challenge is within our grasp, if we (the USA) have the resolve to make it happen. The solution proposed, documented and quantified is to use the supply of US citizen/permanent resident high school graduates with Math ACT scores in the 17-25 range, coupled with Summer Engineering Enrichment Programs or SEEPs, and engineering scholarships and/or stipends, at all ABET accredited engineering programs at public universities (partnered with local Community Colleges) to more than double the number of BS engineer graduates within a decade. The program component for community colleges focuses on enhancing retention of at risk students and developing a seamless transfer of community college graduates to public university ABET accredited engineering programs. Total estimated cost of the program for 320,000 entering students /annually when it reaches a steady state is $8.343 billion (2020 dollars). At full implementation the program produces another estimated 128,000 BS engineers/computer scientists per year in May 2020 at an average estimated cost of approximately $59,453 per engineer. The return on investment for the US taxpayers should be realized relatively quickly from increased IRS revenues and all states would gain substantial increased revenue from state taxes (sales taxes, income taxes, etc). Additional research can better quantify the Return On Investment (ROI) at national and state levels. This analysis does not account for the huge national economic and national security benefits realized from maintaining the technological superiority of the USA, which we have enjoyed since World War II. We postulate that the solution is at hand to rise above the gathering storm in the near term while the longer term solution of enhancing elementary, middle school and high school math and science interest and performance is being undertaken.
Does Business Group’s Conscious of Social Responsibility Enhance its Investment Efficiency? Evidence from ESG Disclosure of China’s Listed Companies

Business groups are industry exemplars whose investment decisions and social responsibility commitments are important for future sustainable development. We use data from China’s listed firms from 2012 to 2018 to investigate the effects of ESG-related disclosure on corporate investment efficiency by comparing the heterogeneity in ESG-related disclosure between group-affiliated firms and standalone firms, as well as between member firms within groups at different pyramid levels. We find that (1) group-affiliated firms are more willing to disclose ESG information than independent ones, and compared with lower-level pyramid member firms, higher-level pyramid member firms have a higher propensity of ESG disclosure; (2) over-investment for group-affiliated firms and under-investment for higher-level pyramid member firms are all moderated by their higher propensity for ESG disclosure. That is, corporate disclosure of ESG information significantly promotes investment efficiency; (3) by grouping the sample firms according to analyst attention and industry external financing dependence, respectively, we find that the promotion effect of ESG disclosure on corporate investment efficiency is more significant when the firms are followed by fewer analysts, or when firms belong to industries with higher external financing dependence. Our findings suggest that ESG disclosure plays an important role in driving a firm’s investment toward desirable levels.
Delayed Clearance of Viral RNA in Sputum for Severity COVID-19 Patients with Initial High Viral Load

Aim To analyze the possible risk factors of delayed virus clearance in hospitalized patients with coronavirus disease 2019 (COVID-19). Methods Retrospective analysis of patients with COVID-19 admitted to the isolation wards from our hospital from 19th Jan 2020 to 18th March 2020. We were collected patient’s data including demographic, epidemiologic, and clinical information, as well as laboratory and radiologic findings. The possible confounding risk factors for prolonged viral RNA shedding of COVID-19 during hospitalization were explored by univariate analysis and any variables with a p value less than 0.05 after univariate analysis were included in a subsequent multivariate logistic regression model analysis. Results The 104 patients included 30 mild patients and 74 severe or critically ill patients. The median duration of viral RNA positivity in sputum was 11 days, and the longest duration of viral RNA positivity was 49 days after admission. Multivariate analysis shown that the used with darunavir/cobicistat treatment (odds ratio [OR]: 4.25, 95% confidence interval [CI]: 1.25–14.42, p = 0.020), duration of fever (OR: 1.15, 95% CI: 1.03–1.30, p = 0.015) and time to radiological improvement (OR: 1.14, 95% CI: 1.01–1.30, p = 0.033) were associated with delayed clearance of SARS-CoV-2 in sputum from COVID-19 patients. Then adjusted in the multivariate binary logistic regression analysis model in severe COVID-19 and found that critical COVID-19 patients (OR: 13.25, 95% CI: 1.45–12.07, p = 0.022), lower virus cycle threshold (CT) values of RT-PCR (OR: 0.96, 95% CI: 0.93–0.99, p = 0.004) and used with darunavir/cobicistat treatment (OR: 8.44, 95% CI: 2.21–32.28, p = 0.022) were associated with delayed clearance of SARS-CoV-2 in sputum from COVID-19 patients. Conclude Clearance of viral RNA in sputum was delayed in severe COVID-19 patients, especially with lower virus CT value. And antivirals with darunavir/cobicistat has little advantage in eliminating SARS-CoV-2.
The Moderating Role of Green Credit between Business Risk and Financial Performance – A Case Study of Chinese Commercial Banks

It attaches great importance to the development of green finance in China, and the bank's green credit business is just the most important link in the green finance project Most of the literature believe that green credit business helps to reduce the business risk of banks and then improve the financial performance of banks. This paper takes the Chinese banking sector from 2011 to 2020 as a research sample, to explore whether the green business in the banking industry can play a mediating role between banks' operational risk and financial performance. The results show that the higher the debt ratio contributes to the ROA and has no significant impact on the ROE, but the higher NPL hurts both ROA and ROE; the more green business also hurts both ROA and ROE; however, the cross term of debt ratio and green business has no significant relationship on ROA, but has a positive significant impact on ROE; the cross term of NPL and green business has a negative significant effect on ROE. We also provide the suggestion for these findings.
Induction Motor DTC Performance Improvement by Inserting Fuzzy Logic Controllers and Twelve-Sector Neural Network Switching Table

Human civilization has changed forever since induction motors were invented. Induction motors are widely used and have become the most prevalent electrical componentsdue to their beneficial characteristics. Many control strategies have been developed for their performance improvement, starting from scalar to vector to direct torque control. The latter, which is a class of vector control, was proposed as an alternative to ensure separate flux and torque control while remaining completely in a stationary reference frame. This technique allows direct inverter switching and reasonable simplicity compared to other vector control techniques, and it is less sensitive to parameter variation. Yet, the use of hysteresis controllers in conventional DTC involves undesired ripples in the stator current, flux, and torque, which lead to bad performances. This paper aims to minimize the ripple level and ensure the system’s performance in terms of robustness and stability. To generate the appropriate reference control voltages, the proposed method is an improved version of DTC, which combines the power of fuzzy logic, neural networks, and an increased number of sectors. Satisfactory results were obtained by numerical simulation in MATLAB/Simulink. The proposed method was proven to be a fast dynamic decoupled control that robustly responds to external disturbance and system uncertainties.
PROFESIONALISME GURU DALAM MENINGKATKAN KUALITAS SUMBER DAYA MANUSIA

Abstract The quality of human resources (SDM), among others, determined by the quality and level of education. The quality of education is low causing low quality of human resources; the higher the education level, the higher the quality of human resources that will affect the way of thinking, reasoning, insight, breadth and depth of knowledge. The professionalism of teachers in improving the quality of human resources will be reflected in the implementation of the tasks that are marked with expertise both in material and methods. With his expertise, a teacher is able to demonstrate its independence, both personal as well as professional stakeholders. In addition to their expertise, professional figure teacher demonstrated through its responsibility in implementing all professional dedication should be able to assume and carry out the responsibility as a teacher to the students, parents, community, nation state, and religion. Teacher professional social responsibility, intellectual, moral, and spiritual. Keywords: professionalism, improve human resources. Abstrak Kualitas sumber daya manusia (SDM) antara lain ditentukan oleh mutu dan tingkat pendidikan. Kualitas pendidikan yang rendah menyebabkan kualitas SDM rendah; makin tinggi tingkat pendidikan maka makin tinggi pula kualitas SDM yang akan berpengaruh terhadap cara pikir, nalar, wawasan, keluasan dan kedalaman pengetahuan. Profesionalisme guru dalam meningkatkan kualitas SDM akan tercermin pada pelaksanaan tugas-tugas yang ditandai dengan keahlian baik dalam materi maupun metode. Dengan keahliannya itu, seorang guru mampu menunjukkan otonominya, baik pribadi maupun sebagai pemangku profesinya. Di samping dengan keahliannya, sosok profesional guru ditunjukkan melalui tanggung jawabnya dalam melaksanakan seluruh pengabdiannya profesional hendaknya mampu memikul dan melaksanakan tanggung jawab sebagai guru kepada peserta didik, orang tua, masyarakat, bangsa negara, dan agamanya. Guru professional mempunyai tanggung jawab sosial, intelektual, moral, dan spiritual. Kata kunci: profesionalisme, meningkatkan, sumber daya manusia.
An Empirical Study on Bugs in Python Interpreters

Python is an interpreted programming language that has been widely used in many fields. The successful execution of a Python program depends on both the correctness of Python program and the correctness of Python interpreter. As an infrastructure software, there are many bugs in the Python interpreter. Exploring the bugs in Python interpreters can help developers and maintainers of Python interpreters detect and fix bugs and help users of Python avoid risks. In this article, we conduct an empirical study on the bugs in two mainstream Python interpreters: CPython and PyPy. By analyzing 25 958 fixed bugs, 18 824 revisions, 2 116 test cases, and root causes of randomly sampled 510 bugs, we have summarized the following findings. <list list-type="ordered"><list-item><label>1)</label><p>The distribution of bugs in the Python interpreter is so uneven that the vast majority of bugs are distributed in a few components and source files. </p></list-item> <list-item><label>2)</label><p>The scales of the testing programs that reveal bugs are small. </p></list-item> <list-item><label>3)</label><p>The fixing works seem to be not complicated since the number of modified source files and lines of code are limited; however, most bugs need a long time to be fixed; nearly 15% of the bugs need more than one year to fix. </p></list-item> <list-item><label>4)</label><p>The priorities of bugs are independent of their locations, but they significantly correlate with duration of bugs. </p></list-item> <list-item><label>5)</label><p>Semantic bugs are the most frequent root causes of bugs, and their proportion exceeds other types of root causes. </p></list-item> </list> These results could indicate some potential problems during the detecting and fixing of Python interpreter’s bugs, and provide some assistance to developers and maintainers of Python interpreters, users of Python, as well as researchers in related fields.
Monitoring and controlling of CO₂ concentrations in open top chambers for better understanding of plants response to elevated CO 2 levels

The exponentially rising concentration of CO2 in the atmosphere is one of the important changes, which effectively influences the productivity of agricultural crops. Innovative approaches for conducting long-term experiments on plants have been developed to investigate the growth and yield response of different plants to predicted elevated levels of CO2. The accuracy of the results depends on the system adopted and its maintenance of the desired CO2 levels with near natural conditions for other parameters. In one of such efforts, a system for continuous monitoring and maintaining the desired level of CO2, temperature and relative humidity in open top chambers (OTCs) was developed. Carbon dioxide gas was supplied to the chambers and maintained at set levels using manifold gas regulators, pressure pipelines, solenoid valves, rotameters, sampler, pump, CO2 analyzer, PC linked Program Logic Control (PLC) and Supervisory Control And Data Acquisition (SCADA). These OTCs are cost effective for meeting the requirements of field research on CO2 enrichment.
Tuberculosis Surveillance in Romania Among Vulnerable Risk Groups Between 2015 and 2017

Purpose Romania has the highest tuberculosis (TB) burden in the European Union/European Economic Area (EU/EEA) comprising almost a quarter (23.4%) of the reported patients in 2017, and a TB notification rate six times higher than the EU/EEA average. Although the overall TB notification rate in Romania declined from 154/100.000 individuals to 66/100.000 individuals in the general population between 2002 and 2017, TB notification rates remain high in certain vulnerable populations groups such as prisoners, the homeless population and among drug users. Patients and Methods We conducted a descriptive study regarding TB monitoring data in Romania, including the aforementioned TB risk groups. Results Analysis regarding notified TB cases among these risk groups indicates that TB rates are 7 to 18 times higher than in the general population. One of the most alarming aspects regards the exceedingly high proportion of HIV-seropositivity among drug users and the high mortality rates among the homeless population and among drug users with TB. Conclusion This data underlines the importance of early identification among social risk groups using outreach active case-finding (ACF) activities, possibly combining TB screening with screening for other common, possibly life-threatening, co-morbidities for which an effective treatment is available. ACF could have a decisive role in TB control and eradication in Romania, when aimed at these high-risk groups.
Iranian college students’ intention towards social distancing in COVID-19 pandemic: An application of the extended theory of planned behavior

ABSTRACT Social distancing as a health-related behavior during epidemics and pandemics, can significantly influence their control. In this regard, the identification of the factors influencing behavior change can play a remarkable role in assessing for how behaviors form. This paper is an attempt to show that the extended theory of planned behavior can provide a useful theoretical framework for explaining social distancing in the face of a contagion disease. The results showed that the constructs of attitude, descriptive norms, perceived behavioral control, and self-efficacy significantly influenced the students’ intention to adhere to social distancing in the form of university closure. Among these constructs, self-efficacy was found to be the main predictor of the students’ intention. Interestingly, the research revealed that injunctive norms were not a significant predictor of the students’ intention. Practically, this study is a justification for the use of attitude, descriptive norms, perceived behavioral control, and self-efficacy in planning and decision-making for encouraging students to adhere to social distancing during epidemics and pandemics, like the COVID-19 pandemic. The extended theory of planned behavior is useful in understanding Iranian College Students’ Intention toward Social Distancing in COVID-19 Pandemic.
New Mutants of Epsilon Toxin from Clostridium perfringens with an Altered Receptor-Binding Site and Cell-Type Specificity

Epsilon toxin (Etx) from Clostridium perfringens is the third most potent toxin after the botulinum and tetanus toxins. Etx is the main agent of enterotoxemia in ruminants and is produced by Clostridium perfringens toxinotypes B and D, causing great economic losses. Etx selectively binds to target cells, oligomerizes and inserts into the plasma membrane, and forms pores. A series of mutants have been previously generated to understand the cellular and molecular mechanisms of the toxin and to obtain valid molecular tools for effective vaccination protocols. Here, two new non-toxic Etx mutants were generated by selective deletions in the binding (Etx-ΔS188-F196) or insertion (Etx-ΔV108-F135) domains of the toxin. As expected, our results showed that Etx-ΔS188-F196 did not exhibit the usual Etx binding pattern but surprisingly recognized specifically an O-glycoprotein present in the proximal tubules of the kidneys in a wide range of animals, including ruminants. Although diminished, Etx-ΔV108-F135 maintained the capacity for binding and even oligomerization, indicating that the mutation particularly affected the pore-forming ability of the toxin.
Splicing Modulation as a Promising Therapeutic Strategy for Lysosomal Storage Disorders: The Mucopolysaccharidoses Example

Over recent decades, the many functions of RNA have become more evident. This molecule has been recognized not only as a carrier of genetic information, but also as a specific and essential regulator of gene expression. Different RNA species have been identified and novel and exciting roles have been unveiled. Quite remarkably, this explosion of novel RNA classes has increased the possibility for new therapeutic strategies that tap into RNA biology. Most of these drugs use nucleic acid analogues and take advantage of complementary base pairing to either mimic or antagonize the function of RNAs. Among the most successful RNA-based drugs are those that act at the pre-mRNA level to modulate or correct aberrant splicing patterns, which are caused by specific pathogenic variants. This approach is particularly tempting for monogenic disorders with associated splicing defects, especially when they are highly frequent among affected patients worldwide or within a specific population. With more than 600 mutations that cause disease affecting the pre-mRNA splicing process, we consider lysosomal storage diseases (LSDs) to be perfect candidates for this type of approach. Here, we introduce the overall rationale and general mechanisms of splicing modulation approaches and highlight the currently marketed formulations, which have been developed for non-lysosomal genetic disorders. We also extensively reviewed the existing preclinical studies on the potential of this sort of therapeutic strategy to recover aberrant splicing and increase enzyme activity in our diseases of interest: the LSDs. Special attention was paid to a particular subgroup of LSDs: the mucopolysaccharidoses (MPSs). By doing this, we hoped to unveil the unique therapeutic potential of the use of this sort of approach for LSDs as a whole.
‘Throwntogetherness’ in hostile environments

In this paper, we set a framework for the Special Feature on urban living together by highlighting the main forces which, we contend, have significantly reshaped urban citizenship in recent times. Nearly two decades after the formulation of Doreen Massey’s influential concept of ‘throwntogetherness’, we engage it in a conversation with differing, often contrasting, urban realities. Throwntogetherness highlights the making of urban space through fluidity, openness and diversity within a ‘power geometry’ of global neoliberalism. We analyse the concept’s engagement with recent countervailing forces, in particular neo-nationalism and the digitisation of the city. These forces have mobilised a range of ‘hostile environment’ policies towards migrant, indigenous and marginalized communities, propelling practices of bordering, denial of rights, housing displacement and exclusion. The new assemblage of forces, we further argue, intensify the dialectic tension between throwntogetherness and ‘thrownapartness’ and increasingly lead to ‘urban apartheid’ in cities across the globe. We draw on contributions to the Special Feature which engage with these tensions in Bologna, Rome, Singapore, Glasgow, Budapest, Jerusalem/Al-Quds and Dhaka. These case studies illustrate the re-making of urban citizens throwntogether and thrownapart in contemporary hostile environments.