Miracle-dz/UniFAR-FTUs huggingface dataset:
Piano: Extremely Simple, Single-Server PIR with Sublinear Server Computation

We construct a sublinear-time single-server pre-processing Private Information Retrieval (PIR) scheme with optimal client storage and server computation (up to poly-logarithmic factors), only relying on the assumption of the existence of One Way Functions (OWF). Our scheme achieves amortized ˜ O ( √ n ) online server computation and client computation and O ( √ n ) online communication per query, and requires e O λ ( √ n ) client storage. Unlike prior single-server PIR schemes that rely on heavy cryptographic machinery such as Homomorphic Encryption, our scheme only utilizes lightweight cryptography such as PRFs, which is easily instantiated in practice. To our knowledge, this is the first practical implementation of a single-server sublinear-time PIR scheme. Compared to existing linear time single-server solutions, our schemes are faster by 10 − 300 × and are comparable to the fastest two-server schemes. In particular, for a 100GB database of 1.6 billion entries, our experiments show that our scheme has less than 40ms online computation time on a single core.
Algorithmic Views of Vectorized Polynomial Multipliers for NTRU and NTRU Prime (Long Paper)

This paper explores the design space of vector-optimized polynomial multiplications in the lattice-based key-encapsulation mechanisms NTRU and NTRU Prime. Since NTRU and NTRU Prime do not support straightforward applications of number– theoretic transforms, the state-of-the-art vector code either resorted to Toom–Cook, or introduced various techniques for coefficient ring extensions. All these techniques lead to a large number of small-degree polynomial multiplications, which is the bottleneck in our experiments. For NTRU Prime, we show how to reduce the number of small-degree polynomial multiplications to nearly 1 / 4 times compared to the previous vectorized code with the same functionality. Our transformations are based on careful choices of FFTs, including Good–Thomas, Rader’s, Schönhage’s, and Bruun’s FFTs. For NTRU, we show how to deploy Toom-5 with 3-bit losses. Furthermore, we show that the Toeplitz matrix–vector product naturally translates into efficient implementations with vector-by-scalar multiplication instructions which do not appear in all prior vector-optimized implementations. We choose the ARM Cortex-A72 CPU which implements the Armv8-A architecture for experiments, because of its wide uses in smartphones, and also the Neon vector instruction set implementing vector-by-scalar multiplications that do not appear in most other vector instruction sets like Intel’s AVX2. Even for platforms without vector-by-scalar multiplications, we expect significant improvements compared to the state of the art, since our transformations reduce the number of multiplication instructions by a large margin. Compared to the state-of-the-art optimized implementations, we achieve 2 . 18 × and 6 . 7 × faster polynomial multiplications for NTRU and NTRU Prime, respectively. For full schemes, we additionally vectorize the polynomial inversions, sorting network, and encoding/decoding subroutines in NTRU and NTRU Prime. For ntruhps2048677 , we achieve 7 . 67 × , 2 . 48 × , and 1 . 77 × faster key generation, encapsulation, and de-capsulation, respectively. For ntrulpr761 , we achieve 3 × , 2 . 87 × , and 3 . 25 × faster key generation, encapsulation, and decapsulation, respectively. For sntrup761 , there are no previously optimized implementations and we significantly outperform the reference implementation.
Privacy-preserving Attestation for Virtualized Network Infrastructures

In multi-tenant cloud environments, physical resources are shared between various parties (called tenants) through the use of virtual machines (VMs). Tenants can verify the state of their VMs by means of deep-attestation : a process by which a (physical or virtual) Trusted Platform Module –TPM – generates attestation quotes about the integrity state of the VMs. Unfortunately, most existing deep-attestation solutions are either: limited to single-tenant environments, in which tenant privacy is irrelevant; are inefficient in terms of linking VM attestations to hypervisor attestations; or provide privacy and/or linking, but at the cost of modifying the TPM hardware. In this paper, we propose a privacy preserving TPM-based deep-attestation solution in multi-tenant environments, which provably guarantees: (i) Inter-tenant privacy : a tenant is unaware of whether or not the physical machine hosting its VMs also contains other VMs (belonging to other tenants); (ii) Configuration privacy : the hypervisor’s configuration, used in the attestation process, remains private with respect to the tenants requiring a hyper-visor attestation; and (iii) Layer linking : our protocol enables tenants to link hypervisors with the VMs, thus obtaining a guarantee that their VMs are running on specific physical machines. Our solution relies on vector commitments and ZK-SNARKs. We build on the security model of Arfaoui et al. and provide both formalizations of the properties we require and proofs that our scheme does, in fact attain them. Our protocol is scalable, and our implementation results prove that it is viable, even for a large number of VMs hosted on a single platform.
Granular Synthesis of Rule-Based Models and Function Approximation Using Rough Sets

comput-abstraCt This chapter suggests a new method to develop rule-based models using concepts about rough sets. The rules encapsulate relations among variables and give a mechanism to link granular descriptions of the models with their computational procedures. An estimation procedure is suggested to compute values from granular representations encoded by rule sets. The method is useful to develop granular models of static and dynamic nonlinear systems and processes. Numerical examples illustrate the main features and the usefulness of the method
Liquid crystal phases in confined geometries

ABSTRACT The orientation control of liquid crystal (LC) phases is essential for fundamental studies as well as practical applications. Surface treatment and topographic confinement have emerged as two of the most effective tools to control ordering and orientation of various types of LC phases. This review is intended to give an overview of the LC phases controlled in confined geometries at micro- and nanometre scales, in which the orientation control methods and the effective analytical techniques will be covered. Finally, the review closes with the applications using such confined LC phases. GRAPHICAL ABSTRACT
Rheumatoid meningitis: a rare neurological complication of rheumatoid arthritis

Objective To describe the clinical and neuroimaging characteristics of rheumatoid meningitis (RM) in Chinese patients. Methods The patients admitted to our hospital with the diagnosis of RM in the past 8 years were retrospectively analyzed. Results Six patients with RM were identified among 933 patients admitted with rheumatoid arthritis (RA). The symptoms of meningitis occurred after onset of arthritis in five patients and before onset in one. Headache (n=6), hyperacute focal neurological deficits (n=4) and seizures (n=3) were the most prevalent symptoms. The nadir modified Rankin Scale score was ≥3 in five patients. Rheumatoid factor was elevated in all patients, and interleukin-6 levels in cerebrospinal fluid were dramatically elevated in three of four tested patients. Magnetic resonance imaging of the brain revealed that the meninges were affected in all patients and the cerebral parenchyma was affected in one patient. The lesions were generally located in the frontoparietal region and showed restricted diffusion along the adjacent subarachnoid space. RM occurred during disease-modifying therapy in four patients. In the acute episode, three patients improved on tocilizumab and the other three improved on pulse corticosteroids. For maintenance therapy, two patients received combined therapy of tocilizumab and other immunosuppressive agents, one received adalimumab and methotrexate, and two received low-dose oral corticosteroids with an immunosuppressive agent. Five patients had a good outcome, and one died of Pneumocystis jirovecii pneumonia after stabilization of his neurologic conditions. No relapse of RM occurred on immunotherapy during follow-up. Conclusions Chinese patients with RM share some remarkable clinical and neuroimaging features and respond well to appropriate immunotherapy. Tocilizumab could be a treatment option for this severe complication of RA.
Protective effect of Schizonepeta tenuifolia Briq. ethanolic extract against UVB-induced skin aging and photodamage in hairless mice

The purpose of this study was to illuminate the mechanism by which Schizonepeta tenuifolia Briq. (ST) ethanolic extract prevents skin photoaging in HR-1 hairless mice (HR-1). The ST ethanolic extract alleviated wrinkle formation, epidermal skin thickness, and collagen degradation in skin tissues of ultraviolet B (UVB)-irradiated HR-1 mice. Expression of matrix metalloproteinases (a wrinkle-related marker) was reduced, and tissue inhibitor of metalloproteinase 1 expression was upregulated following application of ST ethanolic extract. Furthermore, skin dehydration and levels of hyaluronidase-1 and -2 (enzymes that break hyaluronic acid) were decreased. Moreover, protein expression of hyaluronan synthases (markers of skin hydration) and hyaluronic acid levels increased following ST ethanolic extract treatment in UVB-induced photoaging HR-1 mice. In addition, the phosphorylation of mitogen-activated protein kinases (MAPKs), including p38, extracellular signal-regulated kinase, and Jun N-terminal kinase was suppressed, and expression of nuclear factor-kappa was reduced. Treatment with ST ethanolic extract also reduced advanced glycation end product (AGE) accumulation and expression of the receptor for AGE (RAGE) in skin tissue. These results suggest that ST ethanolic extract moderates skin damage caused by UVB irradiation via regulating the expression of wrinkle- and hydration-related proteins, MAPKs, and RAGE.
Clinical characteristics and prognostic factors for short-term outcomes of autoimmune glial fibrillary acidic protein astrocytopathy: a retrospective analysis of 33 patients

Background Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a recently discovered inflammatory central nervous system (CNS) disease, whose clinical characteristics and prognostic factors for short-term outcomes have not been defined yet. We aimed to assess the symptoms, laboratory tests, imaging findings, treatment, and short-term prognosis of GFAP-A. Methods A double-center retrospective cohort study was performed between May 2018 and July 2022. The clinical characteristics and prognostic factors for short-term outcomes were determined. Results We enrolled 33 patients with a median age of 28 years (range: 2–68 years), 15 of whom were children (<18 years). The clinical spectrum is dominated by meningoencephalomyelitis. Besides, we also found nausea, vomiting, poor appetite, and neuropathic pain in some GFAP-A patients, which were not mentioned in previous reports. And adults were more prone to limb numbness than children. Magnetic resonance imaging revealed lesions involving the brain parenchyma, meninges, and spinal cord, exhibiting patchy, linear, punctate, and strip T2 hyperintensities. First-line immunotherapy, including corticosteroid and gamma globulin, was effective in most patients in the acute phase (P = 0.02). However, patients with overlapping AQP4 antibodies did not respond well to first-line immunotherapy and coexisting neural autoantibodies were more common in women. Additionally, the short-term prognosis was significantly better in children than in adults (P = 0.04). Positive non-neural autoantibodies and proven viral infection were independent factors associated with poor outcomes (P = 0.03, 0.02, respectively). Conclusion We expanded the spectrum of clinical symptoms of autoimmune GFAP-A. The clinical symptoms and short-term prognosis differed between children and adults. Positive non-neural autoantibodies and proven viral infection at admission suggest a poor short-term prognosis.
RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis

Recessive X-linked ichthyosis (RXLI), a genetic disorder caused by deletion or point mutations of the steroid sulfatase (STS) gene, is the second most common form of ichthyosis. It is a disorder of keratinocyte cholesterol sulfate retention and the mechanism of extracutaneous phenotypes such as corneal opacities and attention deficit hyperactivity disorder are poorly understood. To understand the pathomechanisms of RXLI, the transcriptome of differentiated primary keratinocytes with STS knockdown was sequenced. The results were validated in a stable knockdown model of STS, to confirm STS specificity, and in RXLI skin. The results show that there was significantly reduced expression of genes related to epidermal differentiation and lipid metabolism, including ceramide and sphingolipid synthesis. In addition, there was significant downregulation of aldehyde dehydrogenase family members and the oxytocin receptor which have been linked to corneal transparency and behavioural disorders respectively, both of which are extracutaneous phenotypes of RXLI. These data provide a greater understanding of the causative mechanisms of RXLI’s cutaneous phenotype, and show that the keratinocyte transcriptome and lipidomics can give novel insights into the phenotype of patients with RXLI.
Branch-site occlusion sign predicts the embolic origin of acute ischemic stroke: a meta-analysis

Objective The study aimed to investigate whether branch-site occlusion (BSO) sign could predict the etiology of acute intracranial large artery occlusion (ILVO) and the stentriever (SR) response. Methods We systematically reviewed studies that evaluated the predictive role of BSO for the etiology of ILVO-AIS or EVT outcome between 1 January 2000 and 31 August 2022 from PubMed, Embase, and Web of Science. Results The sensitivity and specificity of BSO sign predicting etiology of ILVO-AIS were 0.87 (95% CI 0.81–0.91) and 0.64 (95% CI 0.33–0.87), respectively. The sensitivity and specificity of BSO sign predicting stentriever response were 0.84 (95% CI 0.63–0.94) and 0.61 (95% CI 0.18–0.92), respectively. Conclusion The BSO sign could be a valid and precise imaging marker to predict embolism caused ILVO-AIS and recanalization success by SR without rescue therapy.
Evidence of neuroplasticity with brain–computer interface in a randomized trial for post-stroke rehabilitation: a graph-theoretic study of subnetwork analysis

Background Brain–computer interface (BCI) has been widely used for functional recovery after stroke. Understanding the brain mechanisms following BCI intervention to optimize BCI strategies is crucial for the benefit of stroke patients. Methods Forty-six patients with upper limb motor dysfunction after stroke were recruited and randomly divided into the control group or the BCI group. The primary outcome was measured by the assessment of Fugl–Meyer Assessment of Upper Extremity (FMA-UE). Meanwhile, we performed resting-state functional magnetic resonance imaging (rs-fMRI) in all patients, followed by independent component analysis (ICA) to identify functionally connected brain networks. Finally, we assessed the topological efficiency of both groups using graph-theoretic analysis in these brain subnetworks. Results The FMA-UE score of the BCI group was significantly higher than that of the control group after treatment (p = 0.035). From the network topology analysis, we first identified seven subnetworks from the rs-fMRI data. In the following analysis of subnetwork properties, small-world properties including γ (p = 0.035) and σ (p = 0.031) within the visual network (VN) decreased in the BCI group. For the analysis of the dorsal attention network (DAN), significant differences were found in assortativity (p = 0.045) between the groups. Additionally, the improvement in FMA-UE was positively correlated with the assortativity of the dorsal attention network (R = 0.498, p = 0.011). Conclusion Brain–computer interface can promote the recovery of upper limbs after stroke by regulating VN and DAN. The correlation trend of weak intensity proves that functional recovery in stroke patients is likely to be related to the brain’s visuospatial processing ability, which can be used to optimize BCI strategies. Clinical Trial Registration The trial is registered in the Chinese Clinical Trial Registry, number ChiCTR2000034848. Registered 21 July 2020.
Influence of cutting time interval and season on productivity, nutrient partitioning, and forage quality of blue panicgrass (Panicum antidotale Retz.) under saline irrigation in Southern region of Morocco

Salinity has become a major issue in various parts of the world negatively impacting agricultural activities and leading to diminished crop potential and lower yields. Such situation calls for urgent interventions such as adopting salt-tolerant crops to fill the gap in food and feed availability. Blue panicgrass (Panicum antidotale Retz.) is a promising salt-tolerant forage crop that has shown an appropriate adaptation and performance in the saline, arid, and desertic environments of southern Morocco. However, for obtaining a highest forage productivity with nutritional quality, optimization of the cutting interval is required. Thus, the objective of this study was to determine the optimal cutting time interval allowing high forage production and quality under high salinity conditions. This experiment was conducted over one entire year covering the summer and winter seasons. The effect of five cutting time intervals on selected agro-morphological traits, crop productivity, mineral nutrient accumulation, and forage quality of blue panicgrass in the region of Laayoune, southern Morocco. The finding of this study recommend that cutting blue panicgrass every 40 days maximized the annual fresh and dry forage yield as well as the protein yield, which reached 74, 22, and 2.9 t/ha, respectively. This study also revealed a significant effect of the season on both productivity and quality. However, forage yield declined during the winter and increased during the summer, while protein content increased during winter compared to summer. The mineral nutrient partitioning between shoots and roots, especially the K+/Na+ ratio, indicated that blue panicgrass has salt tolerance mechanism as it excluded sodium from the roots and compartmentalized it in the leaves. In conclusion, there is a potential of blue panicgrass on sustaining forage production under salt-affected drylands, as demonstrated by the response to two key questions: (a) a technical question to farmers for its adoption such as at which interval should blue panicgrass be harvested maximizing both forage yield and quality? And (b) a scientific question on how does blue panicgrass maintain high K+/Na+ ratio to cope with salinity stress?
Randomized control trial of a childhood obesity prevention family-based program: “Abriendo Caminos” and effects on BMI

Background Hispanic individuals are at increased risk for obesity and other chronic health conditions. This article evaluates the effect of a family-based, childhood obesity primary prevention intervention in a community setting. Methods A multi-site, randomized controlled trial community program with assessments at pre (T0), post-program (T1), and 6-months post-program (T2). Participating families were recruited from five sites. Only families of Mexican or Puerto Rican heritage with a least one child between 6 and 18 years were included in the study, without weight restrictions. Families were randomized to the intervention and control arms. Intervention families received six-2 h weekly workshops. Control families received printed generic nutrition and wellness information. Heights and weights were measured at the 3-time points to calculate BMI z-scores, BMI-percentiles, and weight status using age- and sex-specific growth charts, according to the CDC guidelines. Results There were no differences in BMI-z scores between children in the intervention (n = 239) and control groups (n = 187) at T0. BMI z-scores decreased in the intervention group (−0.03, 95% CI, −0.066, −0.003, p = 0.032) at T1, but not in the control group at T1. Changes in BMI z-scores were not statistically significant at T2. Conclusion The Abriendo Caminos intervention effectively prevented unhealthy weight gain in Hispanic children in the short-term, but not at 6-months post-intervention. Younger children and girls benefited more from the program at 6-months post-intervention. Additional efforts are needed to sustain long-term changes. Culturally-tailored programs can provide families with the knowledge to produce short-term changes and a potential pathway for sustainable changes in implementing healthy behaviors.
Thermoneutrality and severe malaria: investigating the effect of warmer environmental temperatures on the inflammatory response and disease progression

Introduction Most studies using murine disease models are conducted at housing temperatures (20 – 22°C) that are sub-optimal (ST) for mice, eliciting changes in metabolism and response to disease. Experiments performed at a thermoneutral temperature (TT; 28 – 31°C) have revealed an altered immune response to pathogens and experimental treatments in murine disease model that have implications for their translation to clinical research. How such conditions affect the inflammatory response to infection with Plasmodium berghei ANKA (PbA) and disease progression is unknown. We hypothesized that changes in environmental temperature modulate immune cells and modify host response to malaria disease. To test this hypothesis, we conducted experiments to determine: (1) the inflammatory response to malarial agents injection in a peritonitis model and (2) disease progression in PbA-infected mice at TT compared to ST. Methods In one study, acclimatized mice were injected intraperitoneally with native hemozoin (nHZ) or Leishmania at TT (28 – 31°C) or ST, and immune cells, cytokine, and extracellular vesicle (EV) profiles were determined from the peritoneal cavity (PEC) fluid. In another study, PbA-infected mice were monitored until end-point (i.e. experimental malaria score ≥4). Results We found that Leishmania injection resulted in decreased cell recruitment and higher phagocytosis of nHZ in mice housed at TT. We found 398 upregulated and 293 downregulated proinflammatory genes in mice injected with nHZ, at both temperatures. We report the presence of host-derived EVs never reported before in a murine parasitic murine model at both temperatures. We observed metabolic changes in mice housed at TT, but these did not result to noticeable changes in disease progression compared to ST. Discussion To our knowledge, these experiments are the first to investigate the effect of thermoneutrality on a malaria murine model. We found important metabolic difference in mice housed at TT. Our results offer insights on how thermoneutrality might impact a severe malaria murine model and directions for more targeted investigations.