Miracle-dz/UniFAR-FTUs huggingface dataset:
Cannabis Use Is Inversely Associated with Metabolic Disorders in Hepatitis C-Infected Patients (ANRS CO22 Hepather Cohort)

Background and Aims. Hepatitis C virus (HCV) infection is associated with the onset of metabolic disorders which constitute risk factors for liver disease progression. Their impact may persist after the HCV infection has been cured. Cannabis use is associated with a lower risk of obesity and diabetes in both general and HCV populations. The associations between cannabis use and both dyslipidemia and hypertension have not yet been studied in persons with chronic HCV infection. Methods. Using cross-sectional data from the French ANRS CO22 Hepather cohort, we used regression models to test for an inverse relationship between cannabis use and (i) dyslipidemia, (ii) hypertension, and (iii) the total number of metabolic disorders. Results. Among the 6364 participants in the study population, both former and current cannabis use were associated with a lower risk of hypertension and fewer metabolic disorders. These results were independent of central obesity. Cannabis use was not associated with dyslipidemia. Conclusions. In people chronically infected with HCV, cannabis use was associated with a lower risk of hypertension and a lower number of metabolic disorders. Post-HCV cure studies are needed to confirm these findings using longitudinal data and to test whether they translate into reduced mortality in this population.
Service and demographic factors, health, trauma exposure, and participation are associated with adjustment for former Australian Defense Force members

ABSTRACT Approximately 50% of transitioning service members report difficulty adjusting to civilian life. However, there is limited research exploring factors that influence adjustment for former Australian Defence Force (ADF) members. The aim of this study was to investigate the influence of demographic and service-related characteristics, trauma exposure, health, and participation in meaningful occupations on adjustment for former ADF members. One hundred and ninety-eight former ADF members completed a voluntary, online survey containing validated self-report measures for adjustment, health, and exposure to combat and military sexual trauma. Participation in meaningful occupations was assessed using open-ended questions and a rating scale for frequency of participation. A more difficult adjustment was reported by participants who had completed operational service, reported exposure to combat and/or military sexual trauma, had poor physical health and were discharged for medical reasons. Other characteristics associated with a difficult adjustment included emotional distress, involuntary discharge, age category 30–49 years, final rank of Senior Noncommissioned Officer/Warrant Officer or below, and discharge 6–8 years previously. Employment, voluntary work and care, and social and community interaction were associated with an easier adjustment. Screening tools that consider health, age, deployment type, final rank, type of discharge and exposure to combat or military sexual trauma may be helpful to identify and refer high risk individuals to employment, rehabilitation or transition support programs.
Analysis of Individuals’ Acceptance and Influencing Factors for Young Users of Autonomous Vehicles Using the Hybrid Choice Model

Autonomous vehicles (AVs) are a vital direction for intelligent transportation; nevertheless, the current research is insufficient, and the aspects and mechanisms that influence individuals’ adoption of AVs require additional investigation. This study examines the acceptance of the popularity of AVs from three perspectives: personal-psychological attributes, travel characteristics attributes, and latent variables. The descriptive statistical analysis revealed that the acceptance rate of AVs was 54.6% based on 304 valid questionnaires received through online questionnaires. And the proportion of the 18∼50 group in the article reached 92.8%; thus, this study takes the young group as the object to investigate the acceptance of AVs. A quantitative analysis of each factor’s impact on the acceptability of AVs was conducted using the hybrid choice model (HCM), which was utilized to observe the link between latent variables. Results from parameter estimates demonstrate that the HCM’s fitting impact when latent factors are taken into account is superior to that when latent variables are not taken into account. When latent variables are taken into account, the associated goodness ratio coefficient rises by 0.2337 to 0.2898, which is greater than the model as a whole. The three factors with the highest impact on AV acceptability among the five latent variables were attitude toward use, sense of use gain, and perceived trust, with matching z-test values of 2.42, 2.44, and 2.12, respectively. The development and marketing of AVs by pertinent businesses and government agencies would benefit greatly from this research as a source of reference.
Parental knowledge of children’s developmental milestones in Aseer, Saudi Arabia

Background: Better parental knowledge about developmental milestones of children is linked to better parent–child interaction. Only a handful of surveys have been conducted to evaluate parental knowledge of developme ntal milestones in Arabic-speaking countries. Materials and Methods: The study is a cross-sectional, questionnaire-based observational investigation using a simple random sampling scheme. The sampling frame consisted of all parents attending the family medicine services during the period of conduct of the study. Poisson regression modelling techniques were used to analyse the adjusted effect of sociodemographic factors on knowledge score. Results: Three hundred and seventy-five parents agreed to be included in the study. Only 29 (7.7%) had an excellent knowledge level. Poor knowledge was found among 141 (37.6%) participants. Also, 180 (48%) participants were found to have an acceptable level of knowledge. Mothers achieved acceptable knowledge of developmental milestones better than fathers, and better knowledge was found in less-crowded houses. Physical developmental milestones were known by 304 (81.1%) participants, followed by cognitive development milestones (n = 78, 20.8%), social development milestones (n = 47, 12.5%) and emotional development milestones (n = 85, 22.7%). The internet was the most used source (n = 83, 22.1%). The most avoided sources were educational workshops (n = 230, 61.3%), followed by doctors (n = 159, 42.4%) and social media (n = 130, 34.7%). Conclusions: We confirmed in this work that parental knowledge of children's developmental milestones is suboptimum among Saudi parents. Use of the internet and avoidance of healthcare professionals is a source of concern. Care is required for children coming from overcrowded homes in terms of their developmental progress. Focus should be on educating parents about the social and emotional developmental milestones.
FX swaps, shadow banks and the global dollar footprint

The era of dollar-based financial globalisation has seen a steady rise in the use of foreign exchange (FX) swaps. We provide a macrofinancial political economy perspective on the geography of FX swaps, and the spatial effects of central bank policies aimed at taming instabilities associated with the uneven geography of the dollar. First, we analyse the mechanisms and potential sources of instability involved in accessing dollars using FX swaps and repurchase agreement (repo) contracts, respectively, in both private and public (central bank) use. Second, we show that the distribution of currencies and institutions involved in trading swaps is skewed, reflecting both the dominance of the dollar as international financing currency and the uneven international distribution of dollar-denominated assets and liabilities. We document the changing composition of dollar swap users on both the long-dollar and short-dollar side and identify potential sources of macrofinancial vulnerability for dollar lenders and borrowers. The Fed's approach to global liquidity provision via both swaps and repos constitutes a spatially variegated strategy to preserve the hegemony of the US dollar. Despite its partial success in reducing instability due to cross-border financial imbalances, the Fed's uneven and hierarchical lender of last resort approach cannot sufficiently stabilise global finance to underpin a new era of macrofinancial stability.
The Individuals’ Willingness to Get the Vaccine for COVID-19 during the Third Wave: A Study on Trust in Mainstream Information Sources, Attitudes and Framing Effect

Different inner and external determinants might explain an individual’s willingness to get the vaccine for COVID-19. The current study aims at evaluating the effects of trust in mainstream information sources on individuals’ willingness to get the vaccine and the moderator role of the message framing. Six hundred and thirty-four participants (68.5% females and 31.5% males) were enrolled in an online survey. Participants filled out a questionnaire assessing: trust in mainstream information sources and vaccinal attitude (trust in vaccine benefit, worries over unforeseen future effects, concerns about commercial profiteering, and preference for natural immunity). In addition, participants were randomly exposed to one of four conditions of framing information about the vaccine (gain-probability; gain-frequency; loss-probability; loss-frequency). Results showed that trust in vaccine benefit (b = 9.90; 95% CI: 8.97, 11.73) and concerns about commercial profiteering (b = −4.70; 95% CI: −6.58, −2.81) had a significant effect on the intention to get the vaccine. Further, a significant interaction was observed between loss-gain and trust in vaccine benefit and between frequency-probability and concerns about commercial profiteering. Future vaccination campaigns should consider the individuals’ concerns about vaccine benefit and economic profits to efficaciously deliver frequency-framed or probability-framed information.
Antarctic Submillimeter Telescope and Remote Observatory Observations of 12CO J = 4 → 3 Emission from the N44 Complex in the Large Magellanic Cloud

We present Antarctic Submillimeter Telescope and Remote Observatory (AST/RO) observations of 12CO J = 4 → 3 and [C I] emission in the N44 H II complex in the Large Magellanic Cloud. We detected strong 12CO J = 4 → 3 emission toward the H II region known as N44BC, which is located on the rim of an expanding giant shell in the N44 region. Analysis with a photodissociation region model showed that the 12CO J = 4 → 3 emitting cloud is very dense, with n0 ≈ 105 cm-3. We also note that there is a high-velocity component associated with the 12CO J = 4 → 3 emission. This probably originates from molecular material accelerated as a result of the motion induced by the expanding giant shell surrounding LH 47 in the N44 complex. We found that the kinetic energy of this high-velocity gas observed in the 12CO J = 4 → 3 emission toward the rim of the expanding H II shell is at least a factor of 4 higher than that derived for the H I and H II gas in this region.
Tectona grandis L.f. mediated restoration of marginal lands in Eastern Uttar Pradesh, North India

Tectona grandis L.f. has considerable potential to restore marginal and degraded lands as it offers multiple co‐benefits during the restoration venture. It provides good quality wood for multipurpose use, including biomass for bioenergy and noninvasive traits. For this, aboveground biomass (AGB) was assessed along with testing the critical soil properties (soil physicochemical and biological properties) across different plantation sites during a 4‐year study period (2015–2018). The study suggested that the soil properties like bulk density, moisture content, pH, organic carbon, available nitrogen, phosphorus, and potassium have shown significant mean improvement in all planted sites collectively. These were improved by −0.21 g cm−3, 0.68%, −0.68, 0.27%, 13.69 mg kg−1, 11.77 mg kg−1, 95.20 mg kg−1, respectively, in an arid area (Mirzapur, i.e., M1, M2, M3, M4, M5, and M6 sites, representing a warm and tropical dry climate) from the unplanted control (CM1) during 2015–2018. Moreover, the microbial biomass carbon and dehydrogenase activity were significantly improved by 56.71 mg kg−1 and 6.92 μg TPF g−1 hr−1, respectively, from CM1. Similar results were also observed in the semiarid areas of Varanasi, representing a humid subtropical climatic pattern (i.e., V4 and V5 sites) compared to the unplanted control in the (CV1). Furthermore, the AGB was found between 12.56 and 229.13 kg tree−1, representing 5 and 30 years of plantation, respectively, in 2018. Reference sites (V1, V2, and V3) were also considered that reflect a planted control, which helped assess the comparison between variable sites and the sites under restoration. Therefore, the study further suggested that this tree species has the tremendous potential to restore marginal and degraded lands in the arid and semiarid areas of North India with a significant biomass supply as an additional benefit.
(Es)Ketamine for Suicidal Ideation and Behavior: Clinical Efficacy

Suicidal ideation and behavior are among the most severe psychiatric presentations, warranting emergency room visits and psychiatric admission for higher levels of care. In the United States, suicide rates continue to climb, especially in younger patients, and the continued psychosocial stressors of the COVID-19 pandemic may further exacerbate this crisis. Suicidal ideation and behavior are core features of a major depressive episode, but there are limited treatment options to rapidly redress these life-threatening symptoms. Racemic ketamine and its S-enantiomer, esketamine, are N-methyl-D-aspartate receptor antagonists and glutamate modulators that have robust antidepressant efficacy in treatment-resistant major depressive disorder and bipolar depression. Additionally, both ketamine and esketamine have demonstrated rapid-acting antisuicidal efficacy in major mood disorders. In August 2020, this culminated in a first-in-class approval of Spravato® (intranasal esketamine) for the treatment of major depressive disorder with acute suicidal ideation and behavior. In this article, we review the literature in support of the antisuicidal efficacy of ketamine and esketamine.
Questionnaire-Based Study of 81 Patients in Poland to Evaluate the Course of Inflammatory Bowel Disease and the Effects of the COVID-19 Pandemic on Quality of Life and Mental State from February to June 2021

Background The COVID-19 pandemic affected many people worldwide, including those with chronic diseases. Our objective was to analyze its influence on medical care and the course of inflammatory bowel disease (IBD) in Poland. Material/Methods In 2021, 81 patients in Poland with IBD completed an original anonymous questionnaire about the impact of the COVID-19 pandemic on the course of their disease and mental status. The printed questionnaire was distributed to IBD patients treated at the Gastroenterology Outpatient Clinic of the University Clinical Hospital in Białystok, and an online questionnaire was sent to patients via social media. Statistical analysis was performed using the chi-squared test, with a significance level of P<0.05. Results The study group consisted of 46 women and 35 men with a mean age of 32.42 years. Fifty-nine patients had ulcerative colitis and 22 had Crohn disease. Patients reported significant deterioration in medication availability (50.62%) and restricted access to gastroenterology outpatient clinics (51.90%) (P<0.05). Of patients who contracted COVID-19, 89.47% did not require hospitalization, 32.10% (26/81) were asymptomatic, mild, or moderate, despite immunosuppressive biological treatment (27.16%, 22/81), or steroids (18.52%, 15/81). Over 50% of respondents stated the pandemic negatively affected their mental state and 30% of them associated that with worsening IBD. Conclusions During the pandemic, respondents were mainly concerned with difficulties in accessing the gastroenterology clinic and limited drug availability. The pandemic negatively affected patients’ mental state. In cases of COVID-19 disease, patients with IBD were mostly asymptomatic and did not require hospitalization, despite therapy affecting the immune system.
Emergent geometry and gravity from matrix models: an introduction

An introductory review to emergent noncommutative gravity within Yang–Mills matrix models is presented. Spacetime is described as a noncommutative brane solution of the matrix model, i.e. as a submanifold of . Fields and matter on the brane arise as fluctuations of the bosonic resp. fermionic matrices around such a background, and couple to an effective metric interpreted in terms of gravity. Suitable tools are provided for the description of the effective geometry in the semi-classical limit. The relation to non-commutative gauge theory and the role of UV/IR mixing are explained. Several types of geometries are identified, in particular ‘harmonic’ and ‘Einstein’ types of solutions. The physics of the harmonic branch is discussed in some detail, emphasizing the non-standard role of vacuum energy. This may provide a new approach to some of the big puzzles in this context. The IKKT model with D = 10 and close relatives are singled out as promising candidates for quantum theory of fundamental interactions including gravity.
Exponential Slope from Absolute Lymphocyte Counts during Radio-Chemotherapy Can Predict an Aggressive Course of Cervical Cancer

Simple Summary Lymphopenia associated with clinical outcomes has three potential implications for cancer progression, treatment effects, and constitutional immune capacity. Neutrophil-to-lymphocyte ratio (NLR) and lymphopenia before and after treatment are biomarkers of immune suppression due to cancer progression and treatment effects. A decrease and an increase in the exponential slope (α) estimated from total absolute lymphocyte counts during concurrent radio–chemotherapy for cervical cancer are associated with aggressive and non-aggressive disease courses and are completely independent of stage and NLR. The association between survival and α-related mRNAs from plasma exosomes may imply an insufficient restoration of unstimulated lymphocytes in the context of immune response. The proposed α may be a practical and simple biomarker of constitutional immune capacity. Abstract This study aimed to investigate whether the exponential slope α from absolute lymphocyte counts during concurrent radio–chemotherapy (CRT) is associated with aggressive and non-aggressive courses of cervical cancer. We analyzed 362 patients with stage IB–IVB cervical cancer treated with CRT in two groups: 323 patients without mRNA data (cohort 1) and 39 with mRNA data (cohort 2) from plasma exosomes. We calculated the α of each patient; 69 patients who died of cancer in cohort 1 were divided into 44 who died within 30 months (aggressive group), and 25 who died after more than 30 months (non-aggressive group). The median follow-up periods of cohorts 1 and 2 were 63 and 28 months, respectively. The log2 fold change (log2FC) between read counts of mRNAs before treatment and after the second week of CRT was calculated. Multivariate analyses from cohort 1 showed that neutrophil-to-lymphocyte ratio (NLR) ≥ 2.43 and α < 0.08 were statistically significant predictors of disease-specific survival (DSS) in the aggressive group (DSS-A), whereas α ≥ 0.08 was the only significant predictor of DSS in the non-aggressive group (DSS-NA). The 2.5-year DSS-A and 8-year DSS-NA rates of patients with α ≥ 0.08 and α < 0.08 were 86.7% and 73%, and 78.5% and 94.8% in the high-NLR group, respectively. In cohort 2, patients with both NLR < 2.7 and α ≥ 0.07 had a higher 2.5-year DSS rate than did those with either NLR ≥ 2.72 or α < 0.07. E2F8 and STX6 significantly correlated with ɑ and survival. The 2.5-year DSS rates in patients with E2F8 + STX6 (log2FC) < 0.2429 and ≥0.2429 were 100% and 77.2%, respectively. The exponential slope α can potentially distinguish between aggressive and non-aggressive courses in cervical cancer patients.
Investor’s Learning Style and Knowledge Acquisition Dimension: The Role of ICT in Maximising Knowledge Acquisition

Research aims: This study investigates investor learning style in acquiring knowledge moderated by Information and Communications Technology (ICT). Design/Methodology/Approach: This study performed an online survey method, comprising 263 convergent-type and 210 assimilative-type as the final sample. The Structural Equation Model using Smart-PLS was employed to estimate the relationship of the latent variableResearch findings: The regression results revealed that convergent-type investors positively affected all knowledge acquisition dimensions due to their high experience and knowledge compared to assimilative-type, even with the help of ICT.Theoretical contribution/Originality: This research discloses comprehensive constructs of sophisticated and unsophisticated investors in acquiring knowledge. Widely, it contributes to the literature advancement related to investor learning style, knowledge acquisition, and the role of ICT.Practitioner/Policy implication: It can be used as an ideal individual construct in learning that can be embraced by financial consultants, capital market training institutions, and professional education. Thus, they are also responsible for developing investors' skills, especially novice investorsResearch limitation/Implication: This study did not fully capture the exact participants’ learning styles. Thus, future research is hoped to provide experimental approaches, reaching the natural cause-effect measurement of investor learning style and knowledge acquisition.
The morphosyntax of the Modern Greev verbs as morphology and not syntax

and chains. In Proceedings of the Tenth West Coast Conference on Formal Linguistics, 399-415. Stanford Linguistics Association, Stanford University, Stanford, Calif. [Distributed by University of Chicago Press, Chicago. ] Rizzi, Luigi. 1986. On chain formation. In Syntax and semantics 19: The syntax of pronominal clitics, ed. Hagit Borer, 65-96. New York: Academic Press. Roberts, Ian. 1991. NP-movement, crossover and chainformation. In Representation and derivation in the theory of grammar, ed. Hubert Haider and Klaus Netter, 17-52. Dordrecht: Kluwer. Saito, Mamoru. 1989. Scrambling as semantically vacuous A'movement. In Alternative conceptions of phrase structure, ed. Mark R. Baltin and Anthony S. Kroch, 182200. Chicago: University of Chicago Press.
Comparable Pregnancy Loss and Neonatal Birthweights in Frozen Embryo Transfer Cycles Using Vitrified Embryos from Progestin-Primed Ovarian Stimulation and GnRH Analogue Protocols: A Retrospective Cohort Study

Background: The potential correlation between progestin-primed ovarian stimulation (PPOS) and the risk of compromised embryo competence still lacks sound evidence. Methods: A large retrospective cohort study was used to compare the incidence of pregnancy loss and neonatal birthweights in frozen embryo transfer (FET) cycles using embryos from PPOS and GnRH analogue protocols. Propensity matched scores were used to balance the baseline confounders. Results: A total of 5744 matched cycles with positive hCG test were included to compare the pregnancy outcomes. The incidence of pregnancy loss was similar between PPOS and GnRH analogue groups (19.2% vs. 18.4%, RR 1.02 (0.97, 1.06), p > 0.05). The neonatal birthweights were comparable between two groups, respectively, for singleton births (3337.0 ± 494.4 g vs. 3346.0 ± 515.5 g) and in twin births (2496.8 ± 429.2 g vs. 2533.2 ± 424.2 g) (p > 0.05). Conclusions: The similar incidence of pregnancy loss and neonatal birthweights in FET cycles using embryos from PPOS provided us with a more complete picture about the safety of PPOS.