Miracle-dz/UniFAR-FTUs huggingface dataset:
Von Willebrand factor processing Von-Willebrand-Faktor-ProzessierungHämostaseologie

Von Willebrand factor (VWF) is a multimeric glycoprotein essential for primary haemostasis that is produced only in endothelial cells and megakaryocytes. Key to VWF’s function in recruitment of platelets to the site of vascular injury is its multimeric structure. The individual steps of VWF multimer biosynthesis rely on distinct posttranslational modifications at specific pH conditions, which are realized by spatial separation of the involved processes to different cell organelles. Production of multimers starts with translocation and modification of the VWF prepropolypeptide in the endoplasmic reticulum to produce dimers primed for glycosylation. In the Golgi apparatus they are further processed to multimers that carry more than 300 complex glycan structures functionalized by sialylation, sulfation and blood group determinants. Of special importance is the sequential formation of disulfide bonds with different functions in structural support of VWF multimers, which are packaged, stored and further processed after secretion. Here, all these processes are being reviewed in detail including background information on the occurring biochemical reactions. Schlüsselwörter von-Willebrand-Faktor, Disulfidbrücken, Glykosylierung, Multimersynthese
Fostering the 21 st Century Skills through Scientific Literacy and Science Process Skills

To overcome the challenges of the twenty first century in science and technology sector, students need to be equipped with the 21 st century skills to ensure their competitiveness in the globalization era. They are expected to master the 21 st century skills apart of just being excelled in their academic performance. Therefore, it is crucial to incorporate 21 st century skills in science education. 21 st century skills comprised of four main domains namely digital age literacy, inventive thinking, effective communication and high productivity. Scientific literacy is one of the skills required in digital age literacy. It means knowledge and understanding of the scientific concepts and processes required for personal decision-making, participation in civic and cultural affairs, and economic productivity. Scientific literacy is important in our modern society since they are many issues related to science and technology. Basic science process skills include observing, classifying, measuring and using numbers, making inferences, predicting, communicating and using the relations of space and time. While the integrated science process skills consist of interpreting data, operational definition, control variables, make hypotheses and experimenting. Science students have been cultivated by scientific literacy and science process skills through science classes. With these two skills, it is hoped that the science students have developed some skills needed in 21 st century skills. This paper will further explain about the 21 st century skills, scientific literacy and science process skills. It also explains about the intersection of science process skills and 21 st century skills in science education. Congress
Health Care: Current Reviews Impact of ‘ Pay for Performance ’ on Utilization of Health Services and Quality of Care in Low and Middle Income Countries

The “pay-for-performance” (P4P) tool has been used in low and middle income countries in order to improve the performance of health care providers. It helps to improve the quality of health care and efficiency but it has some drawback like its only focus on a single condition and do not reflect the complexity of caring for patients who had multiple conditions. Objective of this paper is to determine the P4P impact of health care services. Different documents, papers, reports and literature were searched from 2010 to 2012 were included. Medline, Embase, and Google search engine were used for this purpose. “Pay for performance” increase the utilization of health services and quality of health services but its constrained by certain challenges such as immature NGO service sector with weak managerial and technical capacity, conditional cash transfers to households in countries with a large proportion of the population was considered poor. Improvement of quality of health services by incentive pay to stakeholder in developing countries.
Navigation for UAVs using Signals of Opportunity

The reliance of Unmanned Aerial Vehicles (UAVs) on Global Navigation Satellite System (GNSS) for autonomous operation represents a significant vulnerability to their reliable and secure operation due to signal interference, both incidental (e.g. terrain shadowing, ionospheric scintillation) and malicious (e.g. jamming, spoofing). An accurate and reliable alternative UAV navigation system is proposed that exploits Signals of Opportunity (SOP) thus offering superior signal strength and spatial diversity compared to satellite signals. Given prior knowledge of the transmitter’s position and signal characteristics, the proposed technique utilizes triangulation to estimate the receiver’s position. Dual antenna interferometry provides the received signals’ Angle of Arrival (AoA) required for triangulation. Reliance on precise knowledge of the antenna system’s orientation is removed by combining AoAs from different transmitters to obtain a differential Angles of Arrival (dAoAs). Analysis, simulation, and groundbased experimental techniques are used to characterize system performance; a path to miniaturized system integration is also presented. Results from these ground-based experiments show that when the received signal-to-noise ratio (SNR) is above about 45 dB (typically in within 30 km of the transmitters), the proposed method estimates the receiver’s position uncertainty range from less than 20 m to about 60 m with an update rate of 10 Hz.
Prospective Randomized Blinded Study to Compare Laparoscopic and Open Inguinal Hernioplasty

Background: Hernia is one of the common surgical problems. Repair of inguinal hernia is one of the commonest surgical procedures worldwide, irrespective of country, race or socio-economic status and constitutes a major health-care in every country. Subjects and Methods: This is a randomised prospective study done over 50 patients in the department of general surgery of Kamineni hospitals, LB Nagar, Hyderabad during the period of October 2010 to August 2012 with the aim to compare laproscopic inguinal hernia repair and open inguinal hernia repair with regards to post-operative pain, surgical site infections, hospital stay and time taken to return to work, by a randomized study. Results: Compare laparoscopic and mesh inguinal hernia repairs, there is no significant difference in early assessment with regards to duration of operation, post-operative pain, analgesic requirements on the day of surgery and first post-operative day, hospital stay, return to daily and normal activities and post-operative complications. Conclusion: Laparoscopic mesh hernioplasty still remains to be validated with larger number of patients and longer duration of follow up.
Pre-bond TSV Test Optimization and Stacking Yield Improvement for 3D ICs

Through silicon via (TSV) based three-dimensional IC (3D IC) exhibits various advantages over traditional two-dimensional IC (2D IC), including heterogeneous integration, reduced delay and power dissipation, compact device dimension, etc. However, to commercialize 3D IC products, still, many challenges exist. In this dissertation, we focus on conquering two of these challenges. The first challenge is to reduce pre-bond faulty TSV diagnosis time. The second challenge is to improve the compound yield and reduce cost of wafer-on-wafer stacked 3D ICs. Novel ideas are proposed and are demonstrated to be good solutions for these two challenges. Pre-bond TSV testing and defect identification is extremely important for yield assurance of 3D stacked devices. In this dissertation, we proposed a three-step optimization method named “SOS3” to greatly reduce pre-bond TSV test time without losing the capability of identifying certain number of faulty TSVs. The three steps of optimization are as follows. First, an ILP (integer linear programming) model is proposed to generate nearoptimal set of test sessions for pre-bond TSV diagnosis. The sessions generated by our ILP model identify defective TSVs in a TSV network with the same capability as that of other available heuristic methods, but with consistently reduced test time. Second, an iterative greedy procedure to sort the order of test sessions is proposed. Third, a fast TSV identification algorithm is proposed to actually diagnoses the faulty TSVs based on given test sessions. Extensive experiments are done for various TSV networks and the results show SOS3 as a framework greatly speeds up the pre-bond TSV test. SOS3 provides useful known-good-die information for 3D die-on-die, die-on-wafer, and wafer-on-wafer stacking. Wafer-on-wafer stacking offers practical advantages over die-on-die and die-on-wafer stacking in 3D IC fabrication, but it suffers from low compound yield. To improve the
Functional polymorphisms in the MED13L and SLC4A7 genes are associated with pregnancy-induced hypertension

Background: Pregnancy-induced hypertension (PIH), including gestational hypertension (GH) and preeclampsia (PE), might share pathophysiologic mechanisms and genetic risk factors with hypertension. This study aimed to investigate whether genetic risk factors for hypertension also been associated with PIH. Methods: This is a case control candidate gene association study. A total of 84 cases with GH, 108 cases with PE, and 192 age-matched (±1 year) controls were recruited from the Liuyang Municipal Hospital of Maternal and Child Health, Hunan Province of China. Three candidate single nucleotide polymorphisms (SNPs) which have been found to be associated with hypertension or blood pressure (BP) were chosen. The associations between SNPs and GH and PE were analyzed by multiple logistic regression models after adjusting for fetal sex and primipara. Results: GG genotype at mediator complex subunit 13-like (MED13L) rs11067763 was a protective factor for developing GH (GG vs. AA + AG, OR = 0.376, 95%CI = 0.158-0.892) and PE (GG vs. AA + AG, OR = 0.489, 95%CI = 0.245-0.979) in recessive model. AA genotype at solute carrier family 4 member 7 (SLC4A7) rs820430 was a risk factor for developing GH (AA vs. GG + AG, OR = 3.562, 95%CI = 1.343-9.447) and PE (AA vs. GG + AG, OR = 3.351, 95%CI = 1.352-8.303) in recessive model. But no significant association was observed between cytochrome P450 family 21 subfamily A member 2 (CYP21A2) rs2021783 and the GH/PE groups. Conclusions: PIH and hypertension are likely to share genetic risk factors. The associations both between variants of MED13L rs11067763 and GH/PE and between variants of SLC4A7 rs820430 and GH/PE were significant.
Institutional Knowledge at Singapore Management University The Integration of the East and South-East Asian Equity Markets

: This study examines how the degree of capital-market integration of the East and South-East Asian (ESEA) economies varied over the period 1988–2000 following the deregulation of these markets. The deregulation process varied across the countries both in terms of intensity and timing. A greater degree of co-movements in stock prices is a reflection of greater stock-market integration. We employ Geweke’s (1982) measure of feedback for different pairs of markets. For each pair of markets, the Geweke measure shows how co-movements in daily returns of stock prices varied over time. This is followed by the vector autoregression (VAR) analysis to examine the linkages between the stock markets in the ESEA region. Therein we seek to explore whether the financial influence of Japan in the region has overtaken that of the US. A before- and after-Asian financial crisis analysis shows that the linkages and interactions among the markets have increased substantially in the post-crisis era, suggesting that the national markets have become more interdependent. Acknowledgement: Research supports the National University of Singapore Academic Research Grant R-122-000-025-112 and the International Centre for the Study of East Asian Development (ICSEAD) are gratefully acknowledged.
Ultrama fi c Large Igneous Provinces ( LIPs ) : Importance of the Pre-Mesozoic record

Igneous Provinces (LIPs) if they are large (>105 km3), are emplaced in a short duration (ca. < 5 myr) (or consist of short duration pulses), and have intraplate characteristics (i.e. are not associated with normal plate boundary processes). This category includes the classic continental flood basalts, oceanic plateaus, bimodal-rift (passive margin) related packages, but also those events, mainly of Phanerozoic-Proterozoic age, where the plumbing system of dykes, sills and layered intrusions has been exposed by erosion. In the Archean, LIPs may be represented by the greenstone belts of the tholeiite-komatiite association. Felsic magmatism is associated with many LIPs and indeed may be dominant in some cases. LIPs are associated with continental breakup, climatic change, extinction events, and major ore deposits especially of the Ni-Cu-PGE type. Continental LIPs occur on average every 20–30 myr since 2.6 Ga; the Archean record is too poorly preserved for generalizations. LIPs occur both as isolated single events (e.g., 2055 Ma Bushveld event), as approximately coeval but widely separated events (e.g., 65 Ma Deccan and 62 Ma NAIP), and as regional clusters associated with supercontinent breakup (e.g., the 830–750 Ma events associated with the breakup of the proposed supercontinent Rodinia). The LIP record represents a key tool for constraining Proterozoic paleocontinental reconstructions.
NEMATODE SURVEY OF PLANTAIN ORCHARDS IN JATAÍ AND PEROLÂNDIA – GOIÁS STATE, BRAZIL

Banana is an important fruit for Brazil for it is the most produced and consumed fruit in natura . As every cultivated plant, banana trees have their yield affected by pests and diseases. Among the most detrimental pests are the nematodes, which are sadly also ubiquitous in banana orchards. In Jataí and Perolândia, municipalities of the state of Goiás, Brazil, there is few data regarding the genera and population densities of plant parasitic nematodes in banana orchards. Therefore, a survey from 17 orchards is presented in this paper. All of them had plantains (AAB) planted, since it is the prevalent cultivated genetic group in the region. The nematode extraction method consisted in sieving followed by centrifugal separation. Together with the nematode survey, a poll was presented to farmers, which encompassed questions about the general orchard management. Helicotylenchus was the prevailing genus in all samples. Meloidogyne and Pratylenchus also presented high population density in some areas.
in Ischemic Threshold and Nitrate Efficacy Normotensive and Hypertensive Patients with Stable Angina Pectoris

The coexistence of ischemic heart disease with hypertension makes antihypertensive therapy essential, since relief of hypertension may ameliorate the coronary disease. On the other hand, the effect of antianginal nitrate therapy in patients with stable angina pectoris and systemic arterial hypertension is not fully understood. This study assessed the effects of hypertension on the ischemic threshold and the time to moderate angina, measured as parameters of nitrate efficacy. In this double-blind, parallel-group study, 141 patients with stable angina pectoris were randomly assigned to receive 5 mg, 10 mg or 20 mg isosorbide-5-mononitrate or matching placebo bid for 21 days. Ninety-three normotensive and 48 hypertensive patients were compared with regard to the time to moderate anginal pain and the Ischemic threshold before and after nitrate treatment on the first day of the study. The acute nitrate effect 2 h after drug administration was substantially attenuated in hypertensives at both 10 and 20 mg of isosorbide-5mononitrate, with the time to moderate anginal pain being significantly shortened. Impaired vasodilatator response of the arterial vasculature to organic nitrates, probably due to impaired biotransformation of organic nitrates to nitric oxide in hypertensive patients, is suggested as a possible mechanism for the diminished nitrate effect. Thus, oral nitrate therapy does not have the same beneficial antianginal effect in hypertensive patients as it does in normotensives. Dose adjustment based on the pretreatment blood pressure, and the administration of higher doses of oral nitrates should therefore be considered in hypertensive patients suffering from stable angina pectoris. (Hypertens Res 1995; 18: 119-124)
Dose-dependent Effects of Hydralazine on Microcirculatory Function and Hyperthermic Response of Murine FSall Tumors1

The effects of the vasodilator hydralazine (HYD) on microcirculatory function and hyperthermic response were studied in early generation isotransplants of a spontaneous C3Hf/Sed mouse fibrosarcoma (FSall). Red blood cell flux (RBC flux) in superficial tumor regions was assessed using laser Doppler flowmetry. A differential microcirculatory response was seen between tumor and normal skin after 0.25 Mg/gi-p- HYD, the tumor showing a transient increase in flow and the skin remaining almost stable. At 1.0 ^g/g i-P-,the differential response continued, this time with a transient fall in tumor blood flow but again no change in skin flow. High dose hydralazine (10.0 Mg/gÂ¡-P-)was associated with a dramatic and prolonged decrease in tumor blood flow but a lesser and only transient decline in skin flow. Identical doses of hydralazine were given30 min prior to heat treatment (43.5Â°Cfor 15, 30, or 60 min). Tumor growth was measured daily and compared to controls (HT without hydralazine). Hydralazine at 0.25 tig/ g i.p. did not affect heat induced growth delay. At 1.0 fig/g i-P- it significantly increased growth delay upon heat exposures of 15 min, but not after 30 or 60 min HT. Hydralazine at 10 Mg/gi-P-increased growth delay for all heat doses (/' < 0.05). Hydralazine alone had no influence on growth delay of sham-heated tumors. The results obtained clearly indicate that tumor and normal tissues have microcirculatory differences in the time-course, degree and/or direction of response after hydralazine, and that hydralazine has potential for increasing the response of tumor to HT.
VETER İ NER HEK İ MLER DERNE Ğİ DERG İ S İ Evaluation of MMP-9 and iNOS expressions in sheep with encephalitic listeriosis

This study aimed to correlate Matrix Metalloproteinase-9 and iNOS expressions with the severity of histopathological findings in tissue samples taken from sheep with encephalitic listeriosis. Thus, the role of these molecules in the pathogenesis of the disease can be elucidated. After systemic necropsy, tissue samples of adult sheeps with meningoencephalitis were investigated by the culture, histopathological and immunohistochemical methods in the presence of Listeria spp. isolation from tissues was performed in accordance with the USDA-FSIS method with some modifications. Tissue samples were fixed in a 10% buffered formaldehyde solution. Following routine procedures, tissue sections at 5 µm were stained with Hematoxylin and Eosin, investigated under light microscope and photographed. Immunohistochemical staining was performed on the tissues using the avidin-biotin immune peroxidase complex method. Listeria spp. were obtained in 20 (83.3%) of 24 tissue samples with the presence of bright grey-black centred smooth colonies on Listeria Selective Agar and identified as Listeria monocytogenes through the phenotypically supportive tests. Liquefaction necrosis, purulent meningoencephalitis, perivascular cuffing, microabscesses and glial nodules were the most important histopathological findings. MMP-9 immunpositive reactions were observed in the cytoplasm of microglial cells and neurons in areas where inflammatory and necrotic areas are concentrated in medulla oblongata and pons. In perivascular cuffing areas, immune reactions in endothelial cells were detected. We detected iNOS positive reactions in the medulla oblangata and pons, especially in inflammatory cells in the microabscesses. Consequently, a positive correlation (p < 0.05) was found between MMP-9 expression and the severity of histopathological findings in sheep with encephalitic listeriosis. In addition, we found that iNOS expression increased in parallel with the increase in MMP-9 expression.
  ACTA COUNSELING

Indonesia. Abstract: This study aims to measure the effect of health belief model and self-control on the smoking frequencies in active smokers. We applied the quantitative method with multiple linear regression analysis on this research. We tested the main variable using several instruments, each of which had been adapted and modified. The instruments of the health belief model scale, the self-control scale, and the smoking frequencies scale has good reliability. 141 students who were included in active smokers are is the primary object of this study. The results showed that, simultaneously, there was an influence upon health belief model and self-control on the smoking frequencies. Partially, through the results of the t-test, there is a significant effect between the health belief model on the smoking frequencies, as well as between the self-control variables on the smoking frequencies. However, the influence between health belief model and self-control has a very weak influence based on the results of the coefficient of
Molecular Identification of Some Bacterial Zoonosis from Ready-to-Eat Egyptian Barbeque, Smoked and Salted Fishes Treatments and Developments: Veterinary Practice

Background: Salted and smoked fishes are on the upper list of food borne zoonosis, and they symbolize the supreme old-style and predominant Egyptian hazard fishes. Aim of work: The current study concerns the possible public health hazards of Egyptian salted and smoked fish using molecular identification concerning Staphylococcus aureus, Salmonella spp. , Escherichia coli and Listeria monocytogenes . Materials & methods: A total of 425 fish samples were randomly obtained from retail fish shops representing different governorates of Egypt. Enumeration and isolation of the bacteria were done on salt agar; high-salt casein agar and nutrient agar with 3% NaCl. The bacterial isolates were confirmed using multiplex and single PCR. Results: In the current study; 22 (3.143±4.38), 14 (4.67±2.89), 9 (3.00±1.00), and 8 (2.67±1.53) fish samples were recorded positive for S. aureus , L. monocytogenes , E. coli, Salmonella spp. with a recorded ABC/gt of 2 x 103, 6 x 102, 7 x 102, and 9 x 102 respectively. The Egyptian fish samples recorded overall contamination percentage levels as follows; 10.2% in fresh fishes Tilapia spp . , 12.6% in barbecue Tilapia spp . , 8.4% in barbecue Mackerel spp . Scomber scombrus , 11.1% in smoked fishes Hypophthalmichthys molitrix , 15.5% in Salted Molouha Hydrocynous froskali , in 13.5% salted Faseikh Mugil and 10 % in salted Sardine Sardina pilchardus . No coliforms or Salmonella spp . were detected in salted fishes; Molouha, Faseikh and Sardine. The optimum NaCl range for growth was 2-10% while the optimum range of pH was found to be 7-9. The optimal growth temperature was 30°C. Conclusion: We concluded that zoonotic bacteria has been identified over the permissible limits in Egyptian salted and smoked fishes reflecting public health hazards and the necessity of extraordinary Egyptian health supervision and establishment of microbiological standards for salted and smoked fish’s consumers safety.