Miracle-dz/UniFAR-FTUs huggingface dataset:
The acute and prolonged effects of 20-s static stretching on muscle strength and shear elastic modulus

Introduction Static stretching (SS) is commonly performed as part of warm-up routine. However, only few previous studies have reported on the effects of short-duration SS, which is often used in the sports field. The purpose of this study was to investigate the acute and prolonged effects of 20-s SS on isokinetic contraction muscle strength, range of motion (ROM), and the shear elastic modulus. Method Twenty male volunteers participated in this study. The ROM and both concentric and eccentric contraction muscle strengths were measured using a dynamometer. In addition, the shear elastic modulus of medial gastrocnemius muscle in dominant leg was measured by ultrasonic shear wave elastography. The participants visited the laboratory on four occasions each separated by >3 days. The first visit was a familiarization trial, and the subsequent three visits included the following experimental conditions in a random order. All measurements were performed prior to and immediately after SS or 5 min and 10 min after 20-s SS. Results The results of this study showed that the ROM was significantly increased SS intervention in all conditions compared with prior to SS intervention. In addition, ROM was significantly higher post SS and 5 min after SS than 10 min after SS. However, there were no significant interaction effects for isokinetic contraction muscle strength and the shear elastic modulus Conclusion In the sports field, from the point of performance, a 20-s SS intervention could be a useful technique before exercise because it increases ROM and does not decrease maximum torque.
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

Liver disease defect identified The energy sensor adenosine monophosphate–activated protein kinase (AMPK) is implicated in liver damage in nonalcoholic steatohepatitis (NASH), a leading cause of liver-associated death in humans. Zhao et al. used mouse models of NASH and samples from human NASH patients to show that AMPK, the activity of which is lost in NASH, phosphorylates the enzyme procaspase-6. In normal liver cells, this modification limits the activation of caspase-6 and the consequent caspase activation cascade that leads to apoptosis. AMPK and caspase-6 may thus provide therapeutic targets for the treatment of NASH. Science, this issue p. 652 Energy sensor kinase AMPK restrains cell death in liver disease. Liver cell death has an essential role in nonalcoholic steatohepatitis (NASH). The activity of the energy sensor adenosine monophosphate (AMP)–activated protein kinase (AMPK) is repressed in NASH. Liver-specific AMPK knockout aggravated liver damage in mouse NASH models. AMPK phosphorylated proapoptotic caspase-6 protein to inhibit its activation, keeping hepatocyte apoptosis in check. Suppression of AMPK activity relieved this inhibition, rendering caspase-6 activated in human and mouse NASH. AMPK activation or caspase-6 inhibition, even after the onset of NASH, improved liver damage and fibrosis. Once phosphorylation was decreased, caspase-6 was activated by caspase-3 or -7. Active caspase-6 cleaved Bid to induce cytochrome c release, generating a feedforward loop that leads to hepatocyte death. Thus, the AMPK–caspase-6 axis regulates liver damage in NASH, implicating AMPK and caspase-6 as therapeutic targets.
Longitudinal relationship between the child value, parenting stress, and controlling parenting attitudes and the self-esteem of children: Applying the actor-partner interdependence model (APIM) using a latent growth model.

AIM This is a descriptive longitudinal study conducted to identify the effects of the perception of child value by parents on parenting stress, controlling parenting attitudes, and children's self-esteem. METHODS The present study targeted parents aged 19 years or older and their children who participated in the fourth through to the eighth Panel Study on Korean Children. The study examined the longitudinal relationship of the effect of parental factors on self-esteem in children, and applied an actor-partner interdependent model to analyze the effect of interactions with parents. RESULTS The paternal instrumental value had a partner effect on the rate of change in maternal parenting stress, while the maternal instrumental value of children had an actor effect on the rate of change in maternal parenting stress. The baseline value of parenting stress had an actor effect on the baseline value of controlling parenting attitudes, while the rate of change in maternal parenting stress had a partner effect on paternal controlling parenting attitudes and an actor effect on the rate of change in maternal controlling parenting attitudes. The baseline value and rate of change in controlling parenting attitudes were found to influence self-esteem in children. CONCLUSION Reducing parenting stress by increasing the parents' positive perception of the value of children can be helpful in maintaining a consistent parenting attitude by parents, which can have a positive effect on self-esteem in children. It is important to provide intervention and management of variables related to self-esteem in children using a long-term and multidimensional approach.
Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models

Abstract Duchenne muscular dystrophy is a severe pediatric neuromuscular disorder caused by the lack of dystrophin. Identification of biomarkers is needed to support and accelerate drug development. Alterations of metabolites levels in muscle and plasma have been reported in pre-clinical and clinical cross-sectional comparisons. We present here a 7-month longitudinal study comparing plasma metabolomic data in wild-type and mdx mice. A mass spectrometry approach was used to study metabolites in up to five time points per mouse at 6, 12, 18, 24 and 30 weeks of age, providing an unprecedented in depth view of disease trajectories. A total of 106 metabolites were studied. We report a signature of 31 metabolites able to discriminate between healthy and disease at various stages of the disease, covering the acute phase of muscle degeneration and regeneration up to the deteriorating phase. We show how metabolites related to energy production and chachexia (e.g. glutamine) are affected in mdx mice plasma over time. We further show how the signature is connected to molecular targets of nutraceuticals and pharmaceutical compounds currently in development as well as to the nitric oxide synthase pathway (e.g. arginine and citrulline). Finally, we evaluate the signature in a second longitudinal study in three independent mouse models carrying 0, 1 or 2 functional copies of the dystrophin paralog utrophin. In conclusion, we report an in-depth metabolomic signature covering previously identified associations and new associations, which enables drug developers to peripherally assess the effect of drugs on the metabolic status of dystrophic mice.
Cytosolic GLUTAMINE SYNTHETASE1;1 Modulates Metabolism and Chloroplast Development in Roots1[OPEN]

Non-redundant roles are uncovered for rice GLUTAMINE SYNTHETASE1;1 and GLUTAMINE SYNTHETASE1;2 in metabolic homeostasis and chloroplast formation in rice seedling roots. Nitrogen (N) is an essential macronutrient, and the final form of endogenous inorganic N is ammonium, which is assimilated by Gln synthetase (GS) into Gln. However, how the multiple isoforms of cytosolic GSs contribute to metabolic systems via the regulation of ammonium assimilation remains unclear. In this study, we compared the effects of two rice (Oryza sativa) cytosolic GSs, namely OsGS1;1 and OsGS1;2, on central metabolism in roots using reverse genetics, metabolomic and transcriptomic profiling, and network analyses. We observed (1) abnormal sugar and organic N accumulation and (2) significant up-regulation of genes associated with photosynthesis and chlorophyll biosynthesis in the roots of Osgs1;1 but not Osgs1;2 knockout mutants. Network analysis of the Osgs1;1 mutant suggested that metabolism of Gln was coordinated with the metabolic modules of sugar metabolism, tricarboxylic acid cycle, and carbon fixation. Transcript profiling of Osgs1;1 mutant roots revealed that expression of the rice sigma-factor (OsSIG) genes in the mutants were transiently upregulated. GOLDEN2-LIKE transcription factor-encoding genes, which are involved in chloroplast biogenesis in rice, could not compensate for the lack of OsSIGs in the Osgs1;1 mutant. Microscopic analysis revealed mature chloroplast development in Osgs1;1 roots but not in the roots of Osgs1;2, Osgs1;2-complemented lines, or the wild type. Thus, organic N assimilated by OsGS1;1 affects a broad range of metabolites and transcripts involved in maintaining metabolic homeostasis and plastid development in rice roots, whereas OsGS1;2 has a more specific role, affecting mainly amino acid homeostasis but not carbon metabolism.
Adolescents and Adults Undergoing Temperature-Controlled Surgical Instruments vs Electrocautery in Tonsillectomy: A Systematic Review and Meta-analysis of Randomized Clinical Trials.

Importance Several temperature-controlled surgical instruments (TCSIs) have been used in tonsillectomy. However, to our knowledge, a meta-analysis of the differences between modern TCSIs and electrocautery (EC) has not been conducted. Objective To compare TCSIs with EC with regard to the intraoperative and postoperative parameters of tonsillectomy. Data Sources PubMed (MEDLINE), Embase, and the Cochrane Library were searched independently by 2 authors for relevant articles. Study Selection A literature search identified randomized clinical trials comparing the outcomes of TCSIs vs EC. The search keywords were harmonic scalpel, ultracision, PlasmaBlade, coblation, radiofrequency ablation, and tonsillectomy. Studies of adult and adolescent patients were included. Data Extraction and Synthesis Data from each study were extracted. A random-effects model was used in the pooled analysis. Main Outcomes and Measures Four outcomes were analyzed: postoperative pain level on days 1, 2, 7, and 14 after surgery; postoperative bleeding; operative time; and intraoperative blood loss. Results This meta-analysis included 11 studies with a total of 629 unique patients. (Mean ages ranged from 16 to 55 years.) The studies were further categorized by the methods of comparison. Five articles used between-participant comparisons, and 6 used within-participant comparisons (of the left vs right sides of the participant's body). The pooled results of the studies with between-participant measures showed that postoperative pain scores were lower in the TCSI group on the first day (standardized mean differences [SMD], -0.41 [95% CI, -0.77 to -0.06]) and seventh day (SMD, -0.76 [95% CI, -1.47 to -0.04]). The pooled results of the studies with within-participant measures showed that the postoperative pain scores were lower in the TCSI group on the first day (SMD, -0.37 [95% CI, -0.63 to -0.12]) and second day (SMD, -0.60 [95% CI, -1.10 to -0.10]). The pooled analysis of overall bleeding, major bleeding, minor bleeding, primary bleeding, and secondary bleeding in both the types of studies with between-participant measures and those with within-participant measures showed no significant differences between the TCSI and EC groups. Intraoperative blood loss and operative time were not significantly different between the groups. Conclusions and Relevance Compared with EC, TCSIs were associated with significantly reduced pain on the first day after tonsillectomy, per this meta-analysis. The rates of overall bleeding, primary bleeding, secondary bleeding, major bleeding, and minor bleeding between TCSIs and EC were comparable. Intraoperative blood loss and operative time also showed no significant intergroup differences. Surgeons may consider using these modern instruments according to personal experiences, preferences, and cost-effectiveness criteria.
Eye Movements and Fixation-Related Potentials in Reading: A Review

The present review is addressed to researchers in the field of reading and psycholinguistics who are both familiar with and new to co-registration research of eye movements (EMs) and fixation related-potentials (FRPs) in reading. At the outset, we consider a conundrum relating to timing discrepancies between EM and event related potential (ERP) effects. We then consider the extent to which the co-registration approach might allow us to overcome this and thereby discriminate between formal theoretical and computational accounts of reading. We then describe three phases of co-registration research before evaluating the existing body of such research in reading. The current, ongoing phase of co-registration research is presented in comprehensive tables which provide a detailed summary of the existing findings. The thorough appraisal of the published studies allows us to engage with issues such as the reliability of FRP components as correlates of cognitive processing in reading and the advantages of analysing both data streams (i.e., EMs and FRPs) simultaneously relative to each alone, as well as the current, and limited, understanding of the relationship between EM and FRP measures. Finally, we consider future directions and in particular the potential of analytical methods involving deconvolution and the potential of measurement of brain oscillatory activity.
Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia

Background The chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not previously been described in detail. Purpose To investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans. Materials and Methods Fifty-one patients (25 men and 26 women; age range 16–76 years) with laboratory-confirmed 2019-nCoV infection by using real-time reverse transcription polymerase chain reaction underwent thin-section CT. The imaging findings, clinical data, and laboratory data were evaluated. Results Fifty of 51 patients (98%) had a history of contact with individuals from the endemic center in Wuhan, China. Fever (49 of 51, 96%) and cough (24 of 51, 47%) were the most common symptoms. Most patients had a normal white blood cell count (37 of 51, 73%), neutrophil count (44 of 51, 86%), and either normal (17 of 51, 35%) or reduced (33 of 51, 65%) lymphocyte count. CT images showed pure ground-glass opacity (GGO) in 39 of 51 (77%) patients and GGO with reticular and/or interlobular septal thickening in 38 of 51 (75%) patients. GGO with consolidation was present in 30 of 51 (59%) patients, and pure consolidation was present in 28 of 51 (55%) patients. Forty-four of 51 (86%) patients had bilateral lung involvement, while 41 of 51 (80%) involved the posterior part of the lungs and 44 of 51 (86%) were peripheral. There were more consolidated lung lesions in patients 5 days or more from disease onset to CT scan versus 4 days or fewer (431 of 712 lesions vs 129 of 612 lesions; P < .001). Patients older than 50 years had more consolidated lung lesions than did those aged 50 years or younger (212 of 470 vs 198 of 854; P < .001). Follow-up CT in 13 patients showed improvement in seven (54%) patients and progression in four (31%) patients. Conclusion Patients with fever and/or cough and with conspicuous ground-glass opacity lesions in the peripheral and posterior lungs on CT images, combined with normal or decreased white blood cells and a history of epidemic exposure, are highly suspected of having 2019 Novel Coronavirus (2019-nCoV) pneumonia. © RSNA, 2020
Enhancing Temperature Sensitivity of the Fabry–Perot Interferometer Sensor with Optimization of the Coating Thickness of Polystyrene

The exploration of novel polymers for temperature sensing with high sensitivity has attracted tremendous research interest. Hence, we report a polystyrene-coated optical fiber temperature sensor with high sensitivity. To enhance the temperature sensitivity, flat, thin, smooth, and air bubble-free polystyrene was coated on the edge surface of a single-mode optical fiber, where the coating thickness was varied based on the solution concentration. Three thicknesses of the polystyrene layer were obtained as 2.0, 4.1, and 8.0 μm. The temperature sensor with 2.0 μm thick polystyrene exhibited the highest temperature sensitivity of 439.89 pm °C−1 in the temperature range of 25–100 °C. This could be attributed to the very uniform and thin coating of polystyrene, along with the reasonable coefficient of thermal expansion and thermo-optic coefficient of polystyrene. Overall, the experimental results proved the effectiveness of the proposed polystyrene-coated temperature sensor for accurate temperature measurement.
Comprehensive Care for Patients with Sarcoidosis

Sarcoidosis is a multisystem granulomatous disease, associated with significant morbidity and impaired quality of life. Treatment is aimed at recovering organ function, reducing symptom burden and improving quality of life. Because of the heterogeneity and variable disease course, a comprehensive, multidisciplinary approach to care is needed. Comprehensive care includes not only pharmacological interventions, but also supportive measures aimed at relieving symptoms and improving quality of life. The purpose of this review is to summarize the most recent knowledge regarding different aspects of care and propose a structured approach to sarcoidosis management.
Abnormal uterine inflammation in obstetric syndromes: molecular insights into the role of chemokine decoy receptor D6 and inflammasome NLRP3.

The adaptation of the uterine environment into a favourable immunological and inflammatory milieu is a physiological process needed in normal pregnancy. A uterine hyperinflammatory state, whether idiopathic or secondary to hormonal or organic uterine disorders (polycystic ovary syndromes, endometriosis/adenomyosis, fibroids) negatively influences the interactions between decidua and trophoblast, early in gestation, and between chorion and decidua later in pregnancy. Abnormal activation of uterine inflammatory pathways not only contributes to the pathogenesis of the obstetric syndromes, i.e. recurrent pregnancy loss (RPL), preterm delivery (PTD), and pre-eclampsia (PE), but also to correlates with severity. In this review we summarize recent advances in the knowledge of uterine molecular mechanisms of inflammatory modulation in normal pregnancy and obstetric syndromes (RPL, PTD, PE). In particular, we focus on two regulators of uterine/placental inflammation: the NLRP3 inflammasome and the chemokines decoy receptor D6. We performed comprehensive review of the literature in PubMed and Google Scholar databases from 1994 to 2018. The available evidence suggests that: a) the expression of inflammasome NLRP3 is increased in the endometrium of women with unexplained RPL, in the chorioamniotic membranes of women with PTL and in the placenta of women with PE; b) there is a role for abnormal expression and function of D6 decoy receptor at the feto-maternal interface in cases of RPL and PTD; c) the function of placental D6 decoy receptor is impaired in PE. A wider comprehension of the inflammatory molecular mechanisms involved in the pathogenesis of the obstetric syndromes might lead to the identification of new potential therapeutic targets.
Examining the mediating role of perceived stress in the relationship between mindfulness and quality of life and mental health: testing the mindfulness stress buffering model

ABSTRACT Background and objectives: Many studies show that mindfulness can improve quality of life and mental health as well as reduce psychological distress; however, the mechanisms of these effects remain unknown. The mindfulness stress buffering model provides a model for explaining the effects of mindfulness on health outcomes through the mechanism of reducing perceived stress. Therefore, we investigated the mediating role of perceived stress in the relationship between mindfulness and quality of life and mental health. Methods/Design: Three hundred and fifteen soldiers completed the Mindful Attention Awareness scale, Perceived Stress Scale, WHO Quality of Life Assessment, and General Health Questionnaire. Structural equation modeling using bootstrap methods was employed to analyze the data. Results: Results showed that perceived stress partially mediated the relationship between mindfulness and quality of life, and that perceived stress fully mediated the relationship between mindfulness and mental health. Conclusions: Mindfulness yields beneficial effects in improving individuals’ quality of life and improving mental health through reducing perceived stress.
Analysis of Electronic Properties from Magnetotransport Measurements on Ba(Fe1−xNix)2As2 Thin Films

We performed a detailed structural, magnetotransport, and superconducting analysis of thin epitaxial Ba(Fe1−xNix)2As2 films with Ni doping of x = 0.05 and 0.08, as prepared by pulsed laser deposition. X-ray diffraction studies demonstrate the high crystalline perfection of the films, which have a similar quality to single crystals. Furthermore, magnetotransport measurements of the films were performed in magnetic fields up to 9 T. The results we used to estimate the density of electronic states at the Fermi level, the coefficient of electronic heat capacity, and other electronic parameters for this compound, in their dependence on the dopant concentration within the framework of the Ginzburg–Landau–Abrikosov–Gorkov theory. The comparison of the determined parameters with measurement data on comparable Ba(Fe1−xNix)2As2 single crystals shows good agreement, which confirms the high quality of the obtained films.
Assessment and Optimization of the Pediatric Parenteral Nutrition Preparation Process in a Hospital Pharmacy.

BACKGROUND Parenteral nutrition (PN) is associated with risks that could threaten the clinical condition of premature neonates hospitalized in the neonatal intensive care unit. In this work, risk-analysis methodology was implemented to contain the risks associated with the PN production process and improve PN safety. METHODS The Failure Modes, Effects, and Criticality Analysis was performed by a multidisciplinary team. All potential failure modes of the PN preparation process were recorded, and associated risks were scored based on their severity, occurrence, and detectability, with a risk priority number (RPN). All identified failure scenarios and the respective work stages were ranked in descending order of criticality. Corrective actions were proposed to address critical points, and the safety of the process was reassessed by the same method in a prospective manner. RESULTS The highest RPN scores were obtained with the PN composition calculation performed manually (RPN: 530) or electronically (RPN: 478), completion of the PN medical order form (RPN: 354), manual compounding of PN admixtures (RPN: 258), and the structure/organization/maintenance of the PN preparation unit (RPN: 133). The quality and safety of PN admixtures could be compromised by many critical factors, such as the increased particle-microbial load in the unit and the inadequate training/experience of the involved health professionals and their incompliance with the given instructions. The implementation of the proposed corrective measures is expected to reduce the risks of the overall PN production process by 67.5%. CONCLUSIONS Improvement of the PN production process through risk-analysis methodologies enhances safety for premature neonates.