Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical profile of thyroid dysfunction in elderly: An overview

Aim and Objective: To study the presentation and clinical profile of thyroid disorder in elders in the North-West Rajasthan. Subjects and Methods: This study was carried out on 553 elderly patients in the Department of Medicine, S P Medical College, Bikaner, North-Western Rajasthan. All patients above 60 years were included. Clinical examination was done for detection of thyroid disorders and, keep in mind, the sign and symptoms of hypothyroidism and hyperthyroidism. Recently, a new immunoassay methodology has been applied to the measurement of thyroid stimulating hormone (TSH)/T3/T4 level. The analysis was undertaken using SPSS (version 10). Chi-square test was used to examine the association and trends for categorical. Results: There were 456 cases in the age group 60-71 years. 71-80 and >80 years patients were in numbers of 57 and 20, respectively. Prevalence of hyperthyroidism, euthyroidism, and hypothyroidism according to age was 5.9%, 80.9%, and 13.2%, respectively. When we compared TSH with age, no statistically difference was found (χ2 = 9.366, df = 4; P = 0.05). Of 456 cases, 27 (5.9%) were in decrease level, 359 (80.9%) were within normal range, and 60 (13.2%) cases were having increasing pattern of TSH. Around 8 (4.8%) females having decrease level, 135 (81.8%) were having within normal range of TSH, 22 (13.3%) females having increase level. Around 24 (6.5%) male having decrease level while 40 (10.9%) were having increase level of TSH. Weakness is the most common symptoms of thyroid dysfunction. A highly significant difference was found in weakness, feeling cold, constipation, palpitation, and diarrhea (P < 0.001) while significant difference was found in menstrual irregularity, hoarseness of voice, and irritability (P < 0.01). Conclusion: The current study aimed at spectrum of various clinical aspects in the elderly population that differs from typical presentation. As the age advances, the incidence of thyroid disorders increases. Hypothyroidism was more common than hyperthyroidism. Hence, we recommended that more study required knowing clinical presentation of thyroid disorder in elderly populations.
Video design adaptation to youtube advertising formats

This work in progress analyzes how different arousal advertising design may enhance online video advertising effectiveness. Previous research suggests that arousing ending designs could increase ad effectiveness. To test this proposition, our research combines different methodologies: a consumer neuroscience pretest is used to identify high and low arousal sequences; a field study based on a YouTube ad campaign is used as an exploratory study which helps to determine the experimental scenarios to be used in the final study with a large sample size. Preliminary results suggest that ad design need to be adapted to new formats of interactive advertising depending on the advertisers’ goals
Belonging and Indifference to Europe: A Study of Young People in Brussels

»Zugehörigkeitsgefühl und Gleichgültigkeit Europa gegenüber: Eine Erhebung unter jungen Brüsselern«. This paper proposes to contribute to testing the hypothesis of a “drag effect of the habitus” and investigating empirically the significations of the “I/we/they” categories. It is based on “focus groups” organised with 35 young people in Brussels who were interviewed about their relations to the politics at different levels. It aims more generally at gaining a better understanding of how the feelings of belonging work, by focusing on the supposed lack of them and indifference regarding Europe today. The article firstly sums up what the “habitus drag effect” consists of, according to a certain reading of Elias’s work. This section also aims at stressing how this idea from Elias although formulated in the 1980s is still stimulating to consider the EU and legitimacy issues 30 years later. The next section briefly reviews the recent evolutions in EU studies, the major advances and the remaining blind spots. The last and most important part is an attempt to illustrate how empirical material contributes to investigating these blind spots. At the end, the discussions with the young “Brusselers” partially validate, on the one hand, partially refute, on the other hand, and in any case enrich some of the propositions formulated by Elias’s historical sociology, particularly around the “we/they” relationships.
Occurrence Rates of Sulfamethoxazole and Erythromycin- Resistant Bacteria and Drug Concentrations in Wastewater of Integrated Aquaculture-Agriculture (VAC) Sites in Northern Vietnam

Drug contamination selects for drug-resistant bacteria in agriculture products, animal and human bodies and the environments. Relationship between occurrence of drug-resistant bacteria and the drug contamination in integrated aquaculture-agriculture system (VAC) in Vietnam has not been widely reported. In this study, sulfonamides and erythromycin concentration in water samples collected from fish ponds of VAC sites in July 2007 were measured. Sulfamethoxazole (SMX) was found in all water samples of VAC farms ranging from 68.20 ng/l to 326.00 ng/l in pig-VAC farms, 6.14 ng/l in duckVAC farm, 3.22 ng/l in duck+pig-VAC farm. Another sulfadrug, sulfamethazine (SMT) was detected with high concentration in duck+pig-VAC farm (1966 ng/l), followed by pig-VAC farms (6.78–851 ng/l), but not detected in duckVAC farm. Erythromycin was detected in pig-VAC farms (nd–26.6 ng/l) and in duck+pig-VAC farm (3.7 ng/l). No drug-contamination was found in the control site, where no animal was reared. Number of total cultivable bacteria ranged from 103 to 105 CFU/ml. Percents of SMXr bacteria was found to be 16.90–31.44% in pig-VAC farms, and 42.60% in duck+pig-VAC farm. Occurrence rates of SMXr bacteria in VAC farms (5 sites) ranged from 12.8 to 42.6%, whereas in the control site the value was only 4.4%. Considering all the data together, no significant correlation was observed between SMX concentration and occurrence rate of SMXr bacteria (r2 = 0.0158), whereas cross resistance to SMT showed a significant relationship (r2 = 0.8251). ERYr bacteria also showed positive correlation (r2 = 0.5441) with ERY concentration. These findings suggest that, although drug contamination in VAC accelerates drug-resistant bacteria, the one-to-one correlation was not clear. Other selective pressure(s) might play as causative agents for drug resistance.
PPARγ inhibition boosts efficacy of PD-L1 Checkpoint Blockade Immunotherapy against Murine Melanoma in a sexually dimorphic manner

Immune checkpoint blockade-based immunotherapy has become standard of care for multiple cancer types. However, the overall response rates among various cancer types still remain unsatisfactory. There is a pressing clinical need to identify combination therapies to improve efficacy of anticancer immunotherapy. We previously showed that pharmacologic inhibition of PPARγ by GW9662 boosts αPD-L1 and αPD-1 antibody efficacy in treating murine mammary tumors. In addition, we defined sexually dimorphic αPD-L1 efficacy in B16 melanoma. Here, we show a sexually dimorphic response to the combination of GW9662 and αPD-L1 immunotherapy in B16 melanoma. Combination effects were observed in female, but not male hosts. Neither female oöphorectomy impairs, nor does male castration rescue the combination effects, suggesting a sex hormone-independent response to this combination therapy. In diet-induced obese females, melanoma growth remained responsive to the combination treatment, albeit less robustly than lean females. These findings are informative for future design and application of immunotherapy-related combination therapy for treating human melanoma patients by taking gender and obesity status into consideration.
MSc Business Administration International Management Organizational Capabilities for Shared Value Creation: A Multiple Case Study in four Italian B Corporations

4 Introduction. 5 Chapter one: Background. 7 1.1 Conceptual Foundations. 7 1.2 Literature Review. 11 1.2.1 Porter and directly related authors. 12 1.2.2 Academic Research on Shared Value. 14 Chapter two: Theoretical Framework. 19 2.1 The Resource-based view: Resource and Enterprise Level of Analysis. 19 2.2 The RBV in the context of SMEs. 20 2.3 SMEs’ Organizational Capabilities for Shared Value Creation. 23 2.3.1 Shared Vision. 23 2.3.2 Stakeholder Management. 24 2.3.3 Strategic and Environmental Proactivity. 26 Chapter three: Research Design. 28 3.1 Cases Selection. 28 3.2 Data Collection. 29 3.3 Measures and Analysis Strategy. 30 Chapter four: Analysis. 35 4.1 Case Company 1: Dermophisiologique srl. 35 4.2 Case Company 2: Fratelli Carli spa. 39 4.3 Case Company 3: D-Orbit. 43 4.4 Case Company 4: Nativa. 48 4.5 Cross-cases Analysis. 53 4.6 Patterns of Shared Value Creation. 59 Chapter five: Discussion and Conclusion. 62 5.1 Theoretical Implications. 62 5.2 Practical Implications. 64 5.3 Concluding Remarks. 67 References . 69
Social Welfare in Search Games with Asymmetric Information

We consider games in which players search for a hidden prize, and they have asymmetric information about the prize's location. We study the social payoff in equilibria of these games. We present sufficient conditions for the existence of an equilibrium that yields the first-best payoff (i.e., the highest social payoff under any strategy profile), and we characterize the first-best payoff. The results have interesting implications for innovation contests and R&D races.
DGAT1 mRNA PROFILE IN LACTATING RIVER BUFFALOES

Transcript analysis at DGAT1 reveals different mRNA profiles in river buffaloes with extreme phenotypes for milk fat / Gu, Meichao; Cosenza, G. ; Nicolae, I. ; Bota, A. ; Guo, Y. ; DI STASIO, Liliana; Pauciullo, Alfredo. In: JOURNAL OF DAIRY SCIENCE. ISSN 0022-0302. 100:10(2017), pp. 8265-8276. Original Citation: Transcript analysis at DGAT1 reveals different mRNA profiles in river buffaloes with extreme phenotypes for milk fat
SOCIOSEXUALITY, RELATIONSHIP QUALITY AND QUALITY OF LIFE 1 Sociosexual Attitudes and Quality of Life in (Non)Monogamous Relationships: The Role of Attraction and Constraining Forces Among Users of the Second Love Website

Research has typically shown that unrestricted sociosexuality is negatively associated with relationship quality, and that relationship quality is positively associated with quality of life (QoL). However, these findings may be restricted to individuals in monogamous relationships, especially those with prior extradyadic interactions (i.e., non-consensual nonmonogamous; NCNM). Indeed, individuals in consensual non-monogamous (CNM) relationships have more unrestricted sociosexuality and are also more satisfied with and committed to their relationships. Still, little research has examined whether both relationship agreements are associated differently with attraction forces (wanting to be) and constraining forces (having to be) in the relationship, and how they are related to QoL. We conducted a cross-sectional study with 373 heterosexuals (73.2% men, Mage = 41.15, SD = 10.18) registered on Second Love, a dating website for romantically involved individuals. Results showed differences in the hypothesized model, according to relationship agreement. For individuals in CNM relationships, unrestricted sociosexuality was associated with stronger attraction forces, which were then associated with greater QoL. The opposite pattern was found for those in NCNM relationships. Furthermore, and regardless of relationship agreement, unrestricted sociosexuality was associated with weaker constraining forces, which were associated with greater QoL. These results make a novel contribution to the literature on relationship agreements and how they relate to QoL.
The classification of the Sarrothripinae, Chloephorinae, Camptolominae and Nolinae as the Nolidae (Lepidoptera: Noctuoidea).

The morphology of adults and early stages of a wide selection of genera in the Nolinae, Sarrothripinae, Chloephorine and Camptolominae is reviewed in order to answer three questions: whether the group as a whole is monophyletic; its relationship with other groups within the Noctuoidea; resolution of classificatory structure within the group. The second and third questions proceed from a positive answer to the first, which is supported by characters of the cocoon, pupa, adult thorax and male retinaculum and genitalia. Particular note is made of the wide occurrences of tymbal organs in males within the group, mostly at the base of the abdomen, but also in the hindwing and genitalia. Within this new, monophyletic concept of the Nolidae, subfamily and tribal groupings arc identified. Some groups traditionally included in the complex are examined and several excluded, with particular reference to a complex of genera that are better placed in the Bagisarinac. Placement of the genus Eligma HÜBNER [1819] 1816 is still not resolved and requires further study, as docs the relationship of the Nolidae to other noctuoid families. Current hypotheses group them with the Arctiidae and Lymantriidac, or with the Noctuidac.
The Big Five and Burnout among Teachers: the Moderating and Mediating Role of Self-Efficacy

The aim of this study was to analyze the relationship between Big-Five personality traits, perceived self-efficacy (GSES) and dimensions of occupational burnout in accordance with Christina Maslach’s three-factor burnout model (emotional burnout, depersonalization, perceived lack of own accomplishments). Data collected among 271 teachers (82% female) aged 20–68 confirmed findings from previous research that four personality traits (Neuroticism, Extraversion, Agreeableness, Conscientiousness) are correlated with burnout and that they are significant predictors for all dimensions of burnout. In addition, it was shown that GSES plays a moderating role as a buffer that protects people with high levels of neuroticism from a sense of lack of own accomplishments. It was also found that GSES plays a mediating role for the relationship between Extraversion, Conscientiousness and Neuroticism and perceived lack of own accomplishments and that it is a suppressor for the relationship of neuroticism with emotional exhaustion. The results are discussed in the context of personality theories and their possible applications.
RRTM_A_200218 11..18

Mohammad Reza Shirzadi 1Center for Communicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran; 2Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Science, Tehran, Iran Abstract: The genus Leishmania includes a number of protozoan parasites that cause a wide range of infections named leishmaniasis. Leishmaniasis may be appear in three clinical forms — cutaneous (CL), visceral, and mucocutaneous (MCL) — with variation in their presentation and severity: diffuse CL and post–kala-azar dermal leishmaniasis). The prevalent signs of CL are nonhealing ulcers on exposed skin, but infected patients may have other dermatologic symptoms. In the 1960s, amphotericin B deoxycholate was introduced as a second-line therapy for CL and MCL. However, widespread administration of the agent was prevented, due to its renal and systemic toxicity, high price, and obstacles to intravenous use in leishmaniasis-endemic regions. Amphotericin B binds to ergosterol in the photogenic cell membranes and causes changes in membrane permeability, leakage of ions, and finally cell death. Compared to amphotericin B deoxycholate, a higher dose of liposomal amphotericin B should be administered to show the treatment effect. A high percentage of liposomal amphotericin B is “fastened” in the liposome and not biologically effective. Amphotericin B deoxycholate has some toxic effects, and liposomal amphotericin B is meaningfully less toxic compared to it. Treatment options for CL are limited, due to variation in species causing CL and pharmacokinetic issues. Amphotericin B is effective against some particular forms of CL.
Cystoscopic and Histopathologic Patterns in Iraqi Patients with Chronic Cystitis /Painful Bladder Syndrome

*AL-Yarmouk Teaching Hospital. **Al-kindy College of Medicine, Baghdad University. The term interstitial cystitis (IC) was widely used for this complex of symptoms ; that represent a non bacterial or viral chronic inflammation of the bladder of unknown etiology affecting mainly women (5,6,7) . But with time , it was discovered that behind these chronic cystitis like symptoms, a wide spectrum of endoscopic and pathological patterns could exist and not only the classical pathological findings of IC (Hunner ulcer , Bladder glomerulations .) (2,7,8,9) . ABSTRACT: BACKGROUND: Chronic cystitis symptoms with negative cultures always represent achallenge to the urologist because of the uncertainty in etiology and heterogenous pathological findings. OBJECTIVE: To elecit the role of cystoscopy and biopsy in disclosing the different pathological patterns in our patients with chronic cystitis like syndrome and to compare them with the pathological patterns of western patients. PATIENTS AND METHODES: This study included 64 patients (40 males and 24 females) with a persistent symptom complex of supra pubic pain, dysuria,frequency and urgency (cystitis –like syndrome)for 12 months and above , in the absence of neurological and gynaeco logical findings or positive cultures. The mean patient age was 38 years (20-68ys). The mean duration of symptoms was 26 months . All patients were subjected to a full urological evaluation, cystoscopy under G/A with hydro distension , biopsy and histopathologic examination . RESULTS: The commonest cystoscopic findings were dilated vessels, sub mucosal petechial haemorrhage after hydro distension , bilharzial lesions, mucosal cracks and small polypoid masses. Histopathologic examination revealed variable lesions as chr. Inflammatory cell infiltration, Brunns nests, cystitis cystica, metaplasia , Bilharzial reaction and ova and in situ carcinoma. Most patients had more than one lesion , especially sub mucosal petechial haemorrhage associated with bilharzial lesions or in situ carcinoma. CONCLUSION: In our patients, the chronic abacterial cystitis syndrome is common in both males and females and has different pathological findings. It is therefore , different from the pattern of the syndrome found in western patients where it mainly affects females and most often in the form of interstitial cystitis . This may be attributed to the high prevalence of stone disease and bilharziasis in addition to the highly concentrated urine of our patients. We, thus , consider it mandatory to do cystoscopy and bladder biopsy for every patient presenting with chronic cystitis like symptoms.
Work design characteristics as perceived by nurse managers at Assiut University Hospital *

Identifying the components of a given job is an integral part of job design. Designing or redesigning jobs encompasses many factors, and a number of different techniques are available to the manager. Aim of the study: Assess work design characteristics (task characteristics, knowledge characteristics, social characteristics, and work context ) as perceived by nurse managers at Assiut University Hospital. Subject and method: A descriptive study design was used in the present study. The study subject consisted of all the nurse managers having bachelor degree of nursing. A self-administered questionnaire was used for data collection. It included two parts. The first was concerned with data about nurse managers personal data as age and years of experiences. The second was work design characteristics questionnaire which consisted of seventy four items. Results: Work design characteristics had lowest scores of satisfaction with knowledge characteristics, social characteristics and work context (92%, 74%, and 94%) respectively by studied nurse managers. While, task characteristics had higher score which representing (55%) of the studied nurse managers. The four factors of department, age, years of experience and work context score had a negative relation with the task characteristics scores while knowledge characteristics and social characteristics scores had a positive relation with statistically significant differences. Conclusion: The nurse managers were dissatisfied about work design characteristics as regard to knowledge characteristics, social characteristics and work context. While , more than half of nurse managers were satisfied with task characteristics . Recommendations: The findings of the present study have implications for organizations that are attempting to enhance organizational job satisfaction , cost control , and increase productivity through redesigning of the work.
Direct and Carryover Effects of Freshwater, Marine and Fish Conditions on Juvenile, Ocean, and Adult Survival of Snake River Chinook Salmon

All correspondence should be addressed to J. Gosselin. email: gosselin@uw.edu 28 doi:10.23849/npafctr15/28.30. Direct and Carryover Effects of Freshwater, Marine and Fish Conditions on Juvenile, Ocean, and Adult Survival of Snake River Chinook Salmon Jennifer L. Gosselin, Eric Buhle, Chris Van Homes, Susannah Iltis, and James J. Anderson Columbia Basin Research, School of Aquatic and Fishery Sciences, University of Washington, Seattle, WA, USA Northwest Fisheries Science Center, NOAA Fisheries, Seattle, WA, USA Biomark Applied Biological Services, Boise, ID, USA
A Long-Range Dependence Approach

This paper examines the degree of persistence in UK inflation by applying long-memory methods to historical data that span the period from 1660 to 2016. Specifically, we use both parametric and non-parametric fractional integration techniques, that are more general than those based on the classical I(0) vs. I(1) dichotomy. Further, we carry out break tests to detect any shifts in the degree of persistence, and also run rolling-window and recursive regressions to investigate its evolution over time. On the whole, the evidence suggests that the degree of persistence of UK inflation has been relatively stable following the Bretton Woods period, despite the adoption of different monetary regimes. The estimation of an unobserved-components stochastic volatility model sheds further light on the issues of interest by showing that post-Bretton Woods changes in UK inflation are attributable to a fall in the volatility of permanent shocks. JEL Classification: C14, C22, E31
Annals of Immunology & Immunotherapy

Since the mid-1970s, when membrane modules became available, plasma separation techniques have gained in importance especially in the past few years. Systemic autoimmune diseases based on an immune pathogenesis produce autoantibodies and circulating immune complexes, which cause inflammation in the tissues of various organs. In most cases, these diseases have a poor prognosis without treatment. Therapeutic apheresis (TA) in combination with immunosuppressive therapies has led to a steady increase in survival rates over the last 40 years. The different diseases can be treated by various apheresis methods such as therapeutic plasma exchange (TPE) with substitution solution, or with online plasma or blood purification using adsorption columns, which contain biological or non-biological agents. Here, the authors provide an overview of the most important pathogenic aspects indicating that TA can be a supportive therapy in systemic autoimmune diseases such as