Miracle-dz/UniFAR-FTUs huggingface dataset:
Sustained lobe reconnection in Saturn's magnetotail

The degree to which solar wind driving may affect Saturn's magnetosphere is not yet fully understood. We present observations that suggest that under some conditions the solar wind does govern the character of the plasma sheet in Saturn's outer magnetosphere. On 16 September 2006, the Cassini spacecraft, at a radial distance of 37 Rs near local midnight, observed a sunward flowing ion population for ~5 h, which was accompanied by enhanced Saturn Kilometric Radiation emissions. We interpret this beam as the outflow from a long‐lasting episode of Dungey‐type reconnection, i.e., reconnection of previously open flux containing magnetosheath material. The beam occurred in the middle of a several‐day interval of SKR activity and enhanced lobe magnetic field strength, apparently caused by the arrival of a solar wind compression region with significantly higher than average dynamic pressure. The arrival of the high‐pressure solar wind also marked a change in the composition of the plasma‐sheet plasma, from water‐group‐dominated material clearly of inner‐magnetosphere origin to material dominated by light‐ion composition, consistent with captured magnetosheath plasma. This event suggests that under the influence of prolonged high solar wind dynamic pressure, the tail plasma sheet, which normally consists of inner‐magnetospheric plasma, is eroded away by ongoing reconnection that then involves open lobe field lines. This process removes open magnetic flux from the lobes and creates a more Earth‐like, Dungey‐style outer plasma sheet dominantly of solar wind origin. This behavior is potentially a recurrent phenomenon driven by repeating high‐pressure streams (corotating interaction regions) in the solar wind, which also drive geomagnetic storms at Earth.
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

Cancer's alternative means to an end To stay alive and proliferating, tumor cells must maintain their telomeres: the DNA sequences at the ends of chromosomes. The majority accomplish this by activating the enzyme telomerase. However, certain tumor types favor a different mechanism called alternative lengthening of telomeres (ALT), which involves DNA recombination. Flynn et al. delineated the molecular events that occur at the telomeres of ALT-proficient tumor cells by studying the function of a protein that is altered by mutation in these tumors. The analysis revealed a specific protein kinase that is essential for ALT, which could in principle be targeted to halt tumor growth. Science, this issue p. 273 A potential therapeutic strategy is identified for tumor cells that maintain their telomeres by an unusual mechanism. Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination and is prevalent in a subset of human cancers, yet whether it can be exploited therapeutically remains unknown. Loss of the chromatin-remodeling protein ATRX associates with ALT in cancers. Here, we show that ATRX loss compromises cell-cycle regulation of the telomeric noncoding RNA TERRA and leads to persistent association of replication protein A (RPA) with telomeres after DNA replication, creating a recombinogenic nucleoprotein structure. Inhibition of the protein kinase ATR, a critical regulator of recombination recruited by RPA, disrupts ALT and triggers chromosome fragmentation and apoptosis in ALT cells. The cell death induced by ATR inhibitors is highly selective for cancer cells that rely on ALT, suggesting that such inhibitors may be useful for treatment of ALT-positive cancers.
RHEOLOGICAL CHARACTERISTICS OF BITUMEN IN CONTACT WITH MINERAL AGGREGATE (WITH DISCUSSION)

This paper describes a novel way in which a dynamic shear rheometer was used to measure the rheological properties of bitumen before and after accelerated aging while in contact with mineral aggregate. The tests were conducted at a very thin gap setting (25 micrometers) in an attempt to measure the aging effects very near the bitumen-aggregate interface. The experimental program involved testing three straight-run bitumens and one polymer-modified bitumen coated on four mineral aggregates (granite, limestone, greywacke and basalt) and also on stainless steel (used as a control). Evidence is provided to show that mineral aggregates can affect the rheological characteristics and aging susceptibilities of bitumens.
Use of Collocations in Learning Arabic Vocabulary

The use of collocations is considered a highly effective means of learning new vocabulary, as it has been demonstrated to substantially enhance students' proficiency and fluency in the target language. This study aims to investigate the impact of collocations on learning Arabic language vocabulary among the learners of Arabic as a foreign language in the Department of Arabic Language at Umaru Musa Yar’adua University, Katsina, Nigeria. A quasi - experimental design was employed, with a pre-test and post-test approach, using an intact class of 70 undergraduate students, which was divided into experimental (n=35) and control (n=35). A collocation test was used for data collection. After the data analysis, the study found that the p-value level of significance between the two groups was less than . 05 (p=.000, df=68, t=4.673). This suggests that there was a significant difference between learning Arabic vocabulary through collocations in the experimental group and the Grammar and vocabulary method in the control group. Consequently, to effectively teach Arabic vocabulary, it is crucial for teachers of Arabic as a foreign language to prioritize collocations in their lesson content. Moreover, the study provides theoretical and pedagogical implications and recommendations for future research.
Patient Related Outcome Measures Dovepress

Lena Rosenlund Eskil Degsell Asgeir Store Jakola 1Regional Cancer Centre Stockholm, Stockholm, Sweden; 2Institute of Health and Care Sciences, Sahlgrenska Academy, Gothenburg, Sweden; 3Malignant Brain Tumor Pathway, Quality and Patient Safety Department, Karolinska University Hospital, Stockholm, Sweden; 4The Swedish Brain Tumor Association, Stockholm, Sweden; 5Department of Clinical Neurosciences, Institute of Physiology and Neuroscience, Sahlgrenska Academy, Gothenburg, Sweden; 6Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden; 7Department of Neurosurgery, St. Olavs Hospital, Trondheim, Norway Background: Persons with high-grade glioma face both neurological and cancer-related symptoms from the tumor itself and its treatment affecting their daily lives. Survival alone is not an adequate outcome, the quality of the survivorship experience needs to be regarded with equal importance. Patient-reported outcome (PRO) measures can be used to evaluate treatment effects and symptom management interventions. Purpose: The aim of this review was to identify the use, challenges, and potential of PRO measures in survivors of high-grade glioma. Methods: A narrative expert opinion review was performed on the subject. In addition to our own experiences we searched PubMed, Cumulative Index to Nursing and Allied Health Literature, the Cochrane Library, and PsycINFO for brain tumor-specific PRO measures used in the population of adult patients with high-grade glioma, both original articles and reviews were included. Results: There are several PRO measures that have been validated for patients with primary brain tumors including high-grade glioma. PRO measures are used both in clinical trials to evaluate the effect of treatment on health-related quality of life, and in daily clinical practice for holistic needs assessment and symptom management. Common PRO measures used for patients with high-grade glioma are European Organization for Research and Treatment of Cancer general instrument for patients with cancer together with brain tumor module, Functional Assessment of Cancer Therapy-Brain, and MD Anderson Symptom Inventory for Brain Tumor. Neurologic and cognitive disorders often occur in patients with high-grade glioma, which affects patients’ ability to self-report over time, making it more challenging in this population. PRO as a primary outcome seems underutilized. Conclusion: For clinical research, PRO measures need to be used together with other clinical outcome measures rather than replacing traditional outcome measures. Moving to more use of PRO measures in survivorship care has potential to improve patient-caregiverhealthcare team communication, symptom management, and quality of care. Implementing PROs in survivorship care should also involve caregivers and a response based on the results.
Standardizing Your Training Process for Human Activity Recognition Models: A Comprehensive Review in the Tunable Factors

In recent years, deep learning has emerged as a potent tool across a multitude of domains, leading to a surge in research pertaining to its application in the wearable human activity recognition (WHAR) domain. Despite the rapid development, concerns have been raised about the lack of standardization and consistency in the procedures used for experimental model training, which may affect the reproducibility and reliability of research results. In this paper, we provide an exhaustive review of contemporary deep learning research in the field of WHAR and collate information pertaining to the training procedure employed in various studies. Our findings suggest that a major trend is the lack of detail provided by model training protocols. Besides, to gain a clearer understanding of the impact of missing descriptions, we utilize a control variables approach to assess the impact of key tunable components (e.g., optimization techniques and early stopping criteria) on the inter-subject generalization capabilities of HAR models. With insights from the analyses, we define a novel integrated training procedure tailored to the WHAR model. Empirical results derived using five well-known \ac{whar} benchmark datasets and three classical HAR model architectures demonstrate the effectiveness of our proposed methodology: in particular, there is a significant improvement in macro F1 leave one subject out cross-validation performance.
in Bangladesh

We use several modalities to study and measure the broad impact of pneumococcal disease in Bangladesh. The Bangladesh Demographic and Health Survey, a representative sample drawn from the entire country, has identified pneumonia as the leading cause of death among children less than 5 years old in Bangladesh. Extrapolating mortality rates in the survey to the Bangladesh population, an estimated 90,000 children over 1 month and less than 5 years of age die from pneumonia every year in Bangladesh. Surveillance in seven hospital, supported by pneumoADIP
The Interactive Effect of Age and Education on Bonding Social Capital towards Empowerment of Urban Agriculture Communities in Klang Valley, Malaysia

Malaysian government has initiated the Urban Agriculture (UA) program for urban communities since 2006 in an effort to encourage people producing variety of staple food that provides a high-quality, nutritious diet for their own consumption. With the rapid urbanization that is going on in Malaysia, many urban communities need the UA program as a solution to overpriced groceries and expensive food. However, empowering communities through this program is vividly challenging. Hence, this study look at age and education level to find the correct requirements of remunerative and sustainable program. This study utilized a quantitative approach and multi-stage random sampling on 212 UA program community members in Klang Valley. The results show that a majority of respondents possess high levels of bonding social capital and social empowerment. It was revealed that bonding social capital is highly correlated with social empowerment. The interaction analysis suggests that age and education level significantly moderate the relationship between bonding social capital and social empowerment. It signifies that those of young age and high-level education have a more significant impact on the relationship. The findings offer valuable insights for targeted programs promoting social empowerment, considering different age groups and educational backgrounds to achieve positive outcome.
Length, Weight, Age, and Growth of Young-of-year Shoal Bass Raised in a Southwest Georgia Hatchery Pond

We measured total length and weight and estimated daily age of 50 young-of- year shoal bass (Micropterus cataractae) collected from a hatchery pond in southwest Georgia. Daily age was estimated using otoliths and was considered the median age of ring counts from one reader who counted rings in each otolith independently three times. This sample of young-of-year shoal bass averaged 28.55 days old, 24.04 mm in total length, and 0.13 grams in weight. Daily growth rates averaged 0.85 mm day -1 . The length-weight relationship was described by the equation: weight = 0.0043e 0.1399*length . The frequency distribution of daily ages was skewed, suggesting one main spawning period later in the season, lasting approximately 12 days, with young-of-year swim-up beginning 27 March 2003. These are among the first data on young-of-year shoal bass characteristics and we recommend further research to validate daily ring formation in otoliths of this species.
Patients' independence of a nurse for the administration of subcutaneous anti-TNF therapy: A phenomenographic study

Rheumatology nursing supports patients to manage their lives and live as independently as possible without pain, stiffness and functional restrictions. When conventional drugs fail to delay the development of the rheumatic disease, the patient may require biological treatment such as self-administered subcutaneous anti-tumour necrosis factor (TNF) therapy. It is therefore important that the patient perspective focuses on the life-changing situation caused by the administration of regular subcutaneous injections. The aim of this study was to describe variations in how patients with rheumatic diseases experience their independence of a nurse for administration of subcutaneous anti-TNF therapy. The study had a descriptive, qualitative design with a phenomenographic approach and was carried out by means of 20 interviews. Four ways of understanding the patients’ experience of their subcutaneous anti-TNF therapy and independence of a nurse emerged: the struggling patient; the learning patient; the participating patient; the independent patient. Achieving independence of a nurse for subcutaneous anti-TNF injections can be understood by the patients in different ways. In their strive for independence, patients progress by learning about and participating in drug treatment, after which they experience that the injections make them independent.
Cross Industry Capital Structure and Firm Characteristics in Pakistan

: This study attempts to investigate the differences among capital structures in different industrial sectors of Pakistan namely food (sugar), chemicals, materials and construction (cement) and textile industry. The study also analyzes characteristics of the firms included in the industries. The study is based on the secondary data collected from the annual financial reports of the companies for period 2012-2013. The data was analyzed by different statistical tools including descriptive statistics, correlation analysis and regression analysis. The results show that there are differences among the measures of indebtedness and capital structure across the four industries selected for the study. The long-term capital structure shows a positive relation with the size and asset structure of the firm while short-term debt financing has no relation with the growth of the firms. Overall, it can be concluded that significant differences exist among the capital structures of the four industrial sectors selected for the study.
Usage Intention of RFID System in Toll Payment among Klang Valley Residents

In Malaysia, a great traffic congestion always occurs in the expressways during peak times such as going to and from work, weekends, holidays and festivals especially in Klang Valley which has a high population density. To reduce the issue of congestion on expressways, the Malaysian government has announced to use new technology, namely Radio Frequency Identification (RFID). Therefore, the purpose of this study was to examine the influence of attitude, knowledge and perception towards the usage intention of RFID system in toll payment among Klang Valley residents. Theory of Planned Behaviour (TPB) and Technology Acceptance Model (TAM) was adopted to build the research framework. There was a total of 228 residents participated drawn by using systematic sampling method. The data were collected through Google form. The findings of Pearson correlation indicated that attitude (r=0.802; p=0.000), knowledge (r=0.329; p=0.000), and perception (r=0.795; p=0.000) were significantly influenced the usage intention. Meanwhile, from multiple linear regression analysis, it was found that perception had recorded the highest correlation (β=0.446; p=0.000) in influencing Klang Valley residents’ usage intention. Therefore, the service providers should develop a better function of RFID system features in order to fulfil the needs of consumers to improve their performance.
The genetics of male pheromone preference difference between Drosophila melanogaster and D. simulans

Species of flies in the genus Drosophila differ dramatically in their preferences for mates, but little is known about the genetic or neurological underpinnings of this evolution. Recent advances have been made to our understanding of one case: pheromone preference evolution between the species D. melanogaster and D. simulans. Males of both species are very sensitive to the pheromone 7,11-HD that is present only on the cuticle of female D. melanogaster. In one species this cue activates courtship, and in the other it represses it. This change in valence was recently shown to result from the modification of central processing neurons, rather than changes in peripherally expressed receptors, but nothing is known about the genetic changes that are responsible. In the current study, we show that a 1.35 Mb locus on the X chromosome has a major effect on male 7,11-HD preference. Unfortunately, when this locus is divided, the effect is largely lost. We instead attempt to filter the 159 genes within this region using our newfound understanding of the neuronal underpinnings of this phenotype to identify and test candidate genes. We present the results of these tests, and discuss the difficulty of identifying the genetic architecture of behavioral traits and the potential of connecting these genetic changes to the neuronal modifications that elicit different behaviors.
Fertility Variation and Gene Diversity in Forest Populations

Fertility variation, defined as a difference in the ability to create progeny (i.e., reproductive success) among individuals, was reviewed using the related available theoretical and practical literature in an attempt to contribute to and improve future studies on the subject. Fertility variation is a useful guide for various purposes such as gene conservation, seed production programs, forest genetic resource (i.e., seed sources) management, other forestry practices (e.g., regeneration), and evolutional and physiological studies. Many papers and proceedings have been published, including both theoretical and practical approaches, on how fertility variation has improved in the last two decades. Large variations in fertility were widely reported among populations within species and among species. We reviewed the literature and combined our diverse knowledge to examine fertility variations and their linkage parameters. Fertility variations and their related parameters (e.g., gene diversity, status number, effective parent number, parental–balance curves) estimated based on reproductive characteristics have been studied for many years using easy and cheap surveys that are used for different purposes in forest sciences. Their importance is increasing and their use is becoming more widespread because of these advantages, leading to improvements in research papers. While many research papers have recently been published on fertility variations and linkage parameters, a review paper has not been published to date. Therefore, a review paper is needed based on a literature survey and unpublished experience, as a guide for future studies.
A Model of Tourism Destination Competitiveness: The Case of the Italian Destinations of Excellence (Un Modelo De Destino Turístico Competitivo: El Caso De Los Destinos Italianos De Excelencia)

English Abstract: Tourism worldwide is becoming increasingly competitive. Competitiveness has been associated in the tourism literature as a critical element for the success of tourism destinations. Particular emphasis is placed on identifying and analyzing the various factors that influence the competitiveness of tourism destinations. The paper extends the Richie & Crouch (2000) model and develops a set of indicators that considers the different issues concerning tourism competitiveness. The indicators are focused on the various dimensions of sustainability. The paper offers insights into the model, each determinant has been extensively described. The aim of the paper is to test whether and to what extent the current set of indicators integrated into the present model can help explaining the competitiveness of a tourism destination. The model is tested on a unique dataset of 610 Italian Destinations of Excellence. Principal Component Analysis is applied on the responses to the items measuring destination competitiveness.Spanish Abstract: El turismo en todo el mundo se esta volviendo cada vez mas competitivo. La competitividad se ha asociado en la literatura del turismo como un elemento critico para el exito de los destinos turisticos. Se hace especial enfasis en la identificacion y analisis de los diversos factores que influyen en la competitividad de los destinos turisticos. En el documento abarca el Modelo de Richie y Crouch (2000) y desarrolla un conjunto de indicadores que tenga en cuenta los diferentes temas relacionados con la competitividad turistica. Los indicadores se centran en las diversas dimensiones de la sostenibilidad. En el documento se ofrece informacion sobre el modelo, cada determinante ha sido descrito ampliamente. El objetivo de este trabajo es comprobar si – y en que medida – el actual conjunto de indicadores integrados en el modelo actual puede ayudar a explicar la competitividad de un destino turistico. El modelo se ha probado en un conjunto de datos unico de 610 destinos italianos de Excelencia. Analisis de Componentes Principales se aplica en las respuestas a los items que miden la competitividad del destino.