Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of full-length transcriptome and mechanisms of sugar accumulation in Annona squamosa fruit

Annona squamosa is a multipurpose fruit tree employed in nutritional, medicinal, and industrial fields. Its fruit is significantly enriched in sugars, making it an excellent species to study sugar accumulation in fruit. However, the scarcity of genomic resources hinders genetic studies in this species. This study aimed at generating large-scale genomic resources in A. squamosa and deciphering the molecular basis of its high sugar content. Herein, we sequenced and characterized the full-length transcriptome of A. squamosa fruit using PacBio Iso-seq. In addition, we analyzed the changes in sugar content over five fruit growth and ripening stages, and we applied RNA-sequencing technology to investigate the changes in gene expression related to sugar accumulation. A total of 783,647 circular consensus sequences were generated, from which we obtained 48,209 high-quality, full-length transcripts. Additionally, 1,838 transcription factors and 1,768 long non-coding RNAs were detected. Furthermore, we identified 10,400 alternative splicing events from 2,541 unigenes having on average 2–4 isoforms. A total of 15,061 simple sequence repeat (SSR) motifs were discovered and up to three primer pairs were designed for each SSR locus. Sugars mainly accumulate during the ripening stage in A. squamosa. Most of the genes involved in sugar transport and metabolism in the fruit were progressively repressed overgrowth and ripening stages. However, sucrose phosphate synthase involved in sucrose synthesis and more importantly, isoamylase, alpha-amylase, beta-amylase, 4-alphaglucanotransferase genes involved in starch degradation displayed positive correlations with sugar accumulation in fruit. Overall, we provide here a high-quality, full-length transcriptome assembly which will facilitate gene discovery and molecular breeding of A. squamosa. We found that starch degradation during fruit ripening was the main channel for sugar accumulation in A. squamosa fruit, and the key genes positively linked to sugar accumulation could be further studied to identify targets for controlling sugar content in A. squamosa fruit.
Effects of physical exercise on cognitively impaired older adults: a meta-analysis of randomized control trials

Objectives: The main aim of this meta-analysis was to compare the effects of different physical activities on cognitive functions in older adults divided according to cognitive impairment levels. Methods: We searched Web of Science, Scopus, and PubMed for randomized control trials (RCT). A standardized mean difference (SMD) of the pre-post intervention score of global cognitive function tests were calculated by the random model in the Cochrane meta-analyses for people with cognitive impairment generally and across three levels - mild, mild to moderate, and moderate to severe cognitive impairment separately. Additionally, an unstandardized coefficient beta (B) was calculated in generalized linear models to estimate the effects of exercise, cognitive impairment severity, age, female ratio, length of intervention, and time of exercise a week on the global cognitive function. Results: Data from 26 studies involving 1,137 participants from intervention groups and 1,187 participants from control groups were analyzed. Physical exercise had a positive effect on cognitive functions in people across all levels of cognitive impairments SMD (95 % confidence interval [CI]) = 1.19 (0.77 - 1.62); however, heterogeneity was considerably high I 2 = 95%. Aerobic (B = 8.881) and resistance exercise (B = 4.464) was significantly associated with better results in global cognitive functions when compared to active control. A higher number of female participants cin intervention groups had a statistically significant effect on the global cognitive function (B = 0.229). onclusions: Physical exercise was associated with cognitive function improvement in older people with cognitive impairments. Aerobic exercise was more strongly associated than resistance exercise to combat cognitive decline. Keywords: Physical activity, Dementia, Aging, Meta-analysis, Aerobic exercise, Cognitive function
Analysis of E6 Variants of Human Papillomavirus Type 18,45 Isolated from Cervical Cancer Patients in Sichuan Province

The E6 genes of human papillomavirus(HPV) 18 and 45 variants were isolated and amplified by PCR from the tumor tissues of patients with cervical cancer in Sichuan Province of China,and the E6 genes were sequenced for investigating their structural characteristics and variability.The same two point silence mutations were found in three samples of HPV18,and six point mutations were found in one sample of HPV45,resulting in changes of the translated amino acids at two points(T19I and C53F) which are located in the HPV E6 epitope regions.Some point mutations of the HPV45 are identical to those nucleotides found specifically in the HPV18 from these samples,the diversity between HPV18 and HPV45 of Sichuan variants is less by 4.05% than between HPV18 and HPV45 of wild types,this value is lower than that of variants isolated from Africa,which support the hypothesis that the phylogenetic root of HPV18 and 45 is in Africa.
Evaluating the CO distributions from current atmospheric chemistry models using satellite observations from MOPITT and SCIAMACHY

This thesis developed a new CO vertical column density product from near IR observations of the SCIAMACHY instrument aboard ENVISAT. To correct the effects of the ice layer on the SCIAMACHY near-IR detectors a normalization procedure based on collocated MOPITT observations over the oceans was developed. Although in this thesis only SCIAMACHY observations for effective cloud fractions below 20% are used, the remaining effects of clouds can still be large due to the higher cloud top albedo. Thus, a newly developed correction scheme is applied, which explicitly considers the cloud fraction, cloud top height and surface albedo of individual observations. The resulting SCIAMACHY CO data is well suited for the investigation of the CO distribution over the continents, where important emission sources are located. This thesis compared the new SCIAMACHY CO data set, and also observations from the MOPITT instrument, to the results from three chemistry climate models (MATCH, EMAC, and GEOS); the focus of this comparison is on regions with strong CO emissions (from biomass burning or anthropogenic sources). The comparison indicates that over most of these regions the simulated CO vertical column densities are systematically smaller than the satellite observations with the largest differences compared to the SCIAMACHY observations. Because of the high sensitivity of the SCIAMACHY observations for the lowest part of the atmosphere, this indicates that especially close to the surface the model simulations systematically underestimate the true atmospheric CO concentrations, probably caused by an underestimation of the true CO emissions by current emission inventories.
Enacting affordances: an investigation of digitally mediated multimodal assessment in higher education

This thesis examines the incorporation of a digitally mediated audio-visual assignment into theoretical-contextual modules at a UK post-1992 University. A sample of seven student-produced artefacts has been analysed, highlighting the semiotic work undertaken, the expressive resources used, and the types of knowledge conveyed. Semi-structured interviews were conducted with sixteen participants, who provided accounts of their experiences and discussed the perceived value of the assignment. These two sets of empirical material were analysed using grounded theory methods, providing the basis for developing a grounded theory of enacted affordances. The theory is substantive in that it is derived from researching only one specific educational context. However, the final categories are sufficiently abstract to allow transferability, adaptation and refinement in further research within other contexts. The interview analysis created a strong foundation for the theory, by developing a core category of “Assessing subjective task value”, and its main properties and dimensions: academic emotions, relevance, materiality and self-regulation. Combining this with the insights from the artefact analysis, and with the concepts from Gibson’s affordance theory, the thesis reconceptualises digitally mediated multimodal assessment as the dynamic process of affordance enactment The study concludes that different kinds of positive and negative affordances are potentially present within any assignment, and their realisation depends both on the specific assignment features as affordance-bearers, and on the students’ ability to perceive, select and implement beneficial action possibilities. The conclusion is that whilst digitally mediated multimodal assignments can offer additional advantages compared to traditional written coursework, it is not a given that students will engage in an academically meaningful way or have beneficial and motivating experiences. Careful consideration of assessment design is therefore crucial for the successful incorporation of such assignments, weighing up the relevant affordance bearers and their potential impact on students with diverse skills, strategies and prior experiences.
Impact of capture fishery on income and its equity among fisher households in Tripura

The study has assessed the income distribution pattern across fisheries households involved in capture fishery in the state of Tripura. The study is based on the responses of 90 fishers involved in capture fishery and 140 households involved other fisheries activities. The study revealed that the fishers involved in capture fishery, improved equitable distribution of income across the fishers than households involved in other fishery related activities. The study has suggested proper management of capture fishery will lead to more income to the fishers and also will help to bring more equal distribution of income.
Determination of clay mineral aspect ratios from conductometric titrations

Abstract It has been established that disagreements between different methods of particle size determination of clay minerals can be ascribed to the non-spherical shape of the clay particles. However, by having aspect ratios available, particle sizes can be harmonized. One frequently used approach to obtain aspect ratios is to compare particle sizes originating from at least two devices operating on the basis of different physical principles. In this contribution aspect ratios of nine kaolinite-dominated and one dickite-dominated sample were determined by conductometric titrations. The aspect ratios obtained were then successfully used to correlate particle size distributions from dynamic laser scattering and acoustic spectroscopy.
Relevance of Top Management Support, Personal Capabilities, Formalisation of Information System Development on the Performance of Accounting Information Systems at Expedition Companies

: The growth of e-commerce has had a domino effect on various businesses, such as freight forwarding or logistics. Computer-based information systems are needed to process financial data. The data relates to transaction data in an accounting cycle, and presents it in financial reports, where it is needed for logistics company management. This is intended to evaluate the business being run. This study aims to examine and analyze the influence of Top Management Support, Personal Capabilities, Formalization of Information System Development on the performance of accounting information systems at national shipping/logistic/expedition companies in the city of Semarang. The selection of 64 respondents from 9 expedition companies used the convenience sampling method. The results of the study proved that Top Management Support, Personal Capabilities, Information System Development Formalization had a positive and significant effect on the performance of accounting information systems. The application of accounting information systems is expected to help various company activities in an effort to increase the success of performance.
Geometrical isomerism in uranyl chromates I. Crystal structures of (UO2)(CrO4)(H2O)2, [(UO2)(CrO4)(H2O)2](H2O) and [(UO2)(CrO4)(H2O)2]4(H2O)9

Abstract Three uranyl chromate hydrates, (UO2)(CrO4)(H2O)2, [(UO2)(CrO4)(H2O)2](H2O) and [(UO2)(CrO4)(H2O)2]4(H2O)9, have been prepared by evaporation from aqueous solutions. The crystal structure of (UO2)(CrO4)(H2O)2 (monoclinic, C2/m, Z = 16, a = 16.786(2), b = 22.731(2), c = 6.9969(7) Å, β = 90.051(3)°, V = 2669.8(5) Å3) has been solved by direct methods and refined to R1 = 0.065, calculated for 6702 unique observed reflections (|Fo| ≥ 4σF). The crystal structure of [(UO2)(CrO4)(H2O)2](H2O) (monoclinic, P21, Z = 4, a = 9.7206(14), b = 7.1617(10), c = 11.0909(16) Å, β = 92.388(3)°, V = 771.43(19) Å3) has been solved by direct methods and refined to R1 = 0.052, calculated for 4879 unique observed reflections (|Fo| ≥ 4σF). The crystal structure of [(UO2)(CrO4)(H2O)2]4(H2O)9 (monoclinic, P21/c, Z = 4, a = 31.397(1), b = 7.1701(3), c = 16.2480(7) Å, β = 97.515(1)°, V = 3626.3(3) Å3) has been solved by direct methods and refined to R1 = 0.051, calculated for 8164 unique observed reflections (|Fo| ≥ 4σF). Each structure contains chains of composition [(UO2)(CrO4)(H2O)2]. Within the chains, (UO2)O3(H2O)2 pentagonal bipyramids share three equatorial O atoms with CrO4 tetrahedra. The CrO4 tetrahedra in the [(UO2)(CrO4)(H2O)2] chains each share three corners with uranyl polyhedra, and contain one non-shared (terminal) ligand pointing either up or down relative to the plane of the chain. This results in a geometrical isomerism of the uranyl chromate chains that can be described as a sequence of tetrahedra orientations along the chain extension, e.g. . up-down-up-down . or . ududud . [or (ud)∞]. The structures of (UO2)(CrO4)(H2O)2 and [(UO2)(CrO4)(H2O)2](H2O) are based upon the chains of the (ud)∞ type, whereas [(UO2)(CrO4)(H2O)2]4(H2O)9 contains two types of chains: (ud)∞ and (u)∞. The [(UO2)(CrO4)(H2O)2] chains extend in the same direction in each structure and are linked via hydrogen bonds involving H2O molecules.
Does Kashin-beck Disease Present Only Multisite Pain? A Cross-sectional Study of Pain Characteristics in Northwest China

BackgroundKashin-Beck Disease (KBD) is an endemic, chronic joint disease. Multisite joint pain is the primary symptom of KBD, which have profound negative effects on individuals and society. However, studies on joint pain characteristics among the KBD population are still limited. The aims of this study were to explore characteristics of joint pain in patients with KBD and determine associated factors with joint pain. MethodsThis cross-sectional study included 167 patients with KBD and 169 patients from the general population with joint pain from Shaanxi Province in northwest China. Subjects were asked about joint pain characteristics and completed the numeric rating scale (NRS), the graded chronic pain scale (GCPS) and the EuroQol (EQ-5D) questionnaire. Differences between groups were determined using Chi-square, Student’s t, Mann–Whitney U and 1-way ANOVA tests.ResultsCompared with the general group, patients with KBD reported a higher number of pain sites (7.2±3.8 vs 3.5± 1.8), a higher frequency of persistent pain (98.8% vs 50.9%), a higher percentage of analgesics usage (89.2% vs 30.7%), a higher pain intensity (73.8±15.2 vs 50.0±20.7) and pain –related disability (61.2±23.3 vs 41.6±23.2), and lower EQ-5D scores (0.34±0.27 vs 0.59±0.16). Among the 167 KBD patients, painful joints were symmetrically distributed between the bilateral limbs; the 5 most frequently reported painful joints for the bilateral sides were the knees (84.8%), ankles (79.2%), wrists (51.2%), shoulders (49.5%) and elbows (47.7%). The most severe pain joint was the knee (NRS:6.6), followed by the ankles (NRS:5.1), the fingers, shoulders and elbows had the similar NRS scores (NRS:4.0). Additionally, KBD patients experienced neuropathic pain to varying degrees. Compared to males, females reported a higher number of total pain sites, higher intensity and lower quality of life. ConclusionsBesides multisite pain, the KBD patients suffered from symmetrical, persistent, and neuropathic pain. Weight-bearing joints (e.g., knee and ankle) were the most painful. These findings will provide scientific basis for establishing joint pain evaluation criteria and future pain intervention strategies for these KBD patients in China.
Determination of in Vitro Drug Release of Baicalin Liposomes by HPLC

OBJECTIVE:To establish a HPLC method for the determination of in vitro drug release of Baicalin liposomes.METHODS:The separation was performed on a C18 column(150mm×4.6mm,5μm)at 25℃;the mobile phase was composed of methanol-water-phosohoric acid(47∶53∶0.2)at a flow rate of 1.0mL·min-1.The ultraviolet wavelength was set at 280nm and the sample size was 10μL. RESULTS:The calibration curve showed good linearity in the range of 1.01～80. 80μg·mL-1(r=0.999 8)and the average recovery rate was 100.05%(RSD=0.93%). CONCLUSION:The method is sensitive,simple and accurate,and applicable for the study of in vitro drug release of Baicalin liposomes.
An Analytical Study of Impact of International Merger and Acquisitions on the Financial Performance for Higher Education Institution in the United States

The paper summarizes the arguments and counterarguments within the scientific discussion on the issues such as higher education institutions, mergers and acquisitions, world class universities, integrated postsecondary educational data system in the United States. The main purpose of this scientific research study problem is the impact of international merger and acquisition on the financial performance for higher education institution in the United States. Synthesis of this topic has a significant impact on the financial well-being for all students and professors around the World. The methodology is the observation then synthesis all current and prior existing literature and facts available for the purpose of understanding the current financial situation for all higher education industry. The paper presents the results of a critical thinking analysis integrated postsecondary education data system. The U.S. Department of Education’s National Center for Education Statistics for higher education institutions database system, called the Integrated Postsecondary Education Data System. This U.S. Government run database has collected annual higher education institutions level information since 1986 and by statute requires all Title IV higher education institutions to report in an accurate and timely manner to this database. This research contributed to the advancement of scientific knowledge in that it provided a research study on the interaction effects between time and merger status upon the performance metrics which generalize across regional, state, and national landscapes. Practical implications address how interested higher education institutions stakeholders can use this study to analyze the historical interaction effects between merger status and time on performance metrics which they wish to improve. The future implications discussion includes how this research study provided what researchers in the field have asked for and how this increased knowledge of merger and acquisitions longitudinal effects on performance metrics provides a framework for further study in this area. Keywords: merger, acquisitions, higher education institutions, revenues.
Learner Difficulties and Strategy Choice when Learning to Read in a Genetically Related Language: The Case of a Ukrainian Language Learner

In both academic studies and anecdotal reports, there is widespread consensus that learners tend to learn a language more easily if it is linguistically close to another language in their repertoire, particularly if the languages are genetically related (i.e. belonging to the same linguistic family tree). While there is evidence for such statement to hold true thanks to the phenomenon of transfer, there seems to be an unspoken overarching assumption that the process of learning a genetically related target language is natural and without major problems, and the role of language learner strategies (LLS) is somewhat undermined in such contexts. In light of this issue, this study purports to investigate two areas within the specific skill of reading: (a) learner difficulties that emerge when learning a genetically related language at beginner level and (b) the underlying mental processes that govern corresponding strategy choices. Taking the form of a single case study under a qualitative, constructivist paradigm, this research depicts the self-studying journey of a male Taiwanese individual, who, as a former Russian language learner, learns to read a closely related language—Ukrainian. With data from reading task sheets, stimulated recalls, and a semi-structured interview, the findings identify four learner difficulties that surface when starting to read in said context, thus problematising the aforementioned general claim that a genetically related target language is largely straightforward to learn. The data also shed light on thinking processes fundamental to the decision of strategies, advocating a critical convergence between the fields of language learner strategies and second language acquisition in the discussion section. Finally, the contributions, pedagogical implications, and limitations of the study are addressed in
Cytohistologic Features of Salivary Gland Lymphomas.

Lymphoproliferative lesionsincluding both reactive proliferations and lymphomatypically account for roughly 5% of parotid FNA cases(1). Lymphoma involving the salivary glands is rare, accounting for <5% of all salivary gland neoplasms and 5% of all primary extranodal non-Hodgkin lymphomas. About 75–80% of salivary gland lymphomas involve the parotid gland, with another 15–20% arising in the submandibular gland, and <5% occurring in the sublingual and minor salivary glands(2). The most common forms of salivary gland lymphoma are mucosa-associated lymphoid tissue (MALT) lymphoma, follicular lymphoma, and diffuse large B cell lymphoma, which together account for about 75% of cases(3). Hodgkin lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and mantle cell lymphoma rarely occur in salivary gland, each accounting for <5% of cases(3,4).