Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Aesthetics in Intentions to Use Digital Health Interventions

Digital interventions are increasingly recognised as cost-effective treatment solutions for a number of health concerns, but adoption and use of these interventions can be low, affecting outcomes. This research sought to identify how individual aesthetic facets and perceived trust may influence perceptions toward and intentions to use an online health intervention by building on the Technology Acceptance Model, where perceived attractiveness, perceived usefulness, perceived ease of use and perceived enjoyment are thought to predict behavioural intentions towards a website. An online questionnaire study assessed perceptions of nine stimuli varying in four aesthetic facets (simplicity, diversity, colour & craftsmanship), utilising a quasi-experimental within-subjects design with a repetition among three different groups: individuals from the general population who were shown stimuli referring to general health (GP-H) (N = 257); individuals experiencing an eating disorder and shown stimuli referring to eating disorders (ED-ED) (N = 109); and individuals from the general population who were shown stimuli referring to eating disorders (GP-ED) (N = 235). Linear mixed models demonstrated that perceptions of simplicity and craftsmanship significantly influenced perceptions of usefulness, ease of use, enjoyment and trust, which in turn influenced behavioural intentions. This study demonstrates that developing the TAM model to add a further construct of perceived trust could be beneficial for digital health intervention developers. In this study, simplicity and craftsmanship were identified as the aesthetic facets with the greatest impact on user perceptions of digital health interventions.
lncSNHG3 drives breast cancer progression by epigenetically increasing CSNK2A1 expression level

Mounting evidence demonstrates that long noncoding RNAs (lncRNAs) have critical roles in the initiation and progression of cancer. Here, we report that small nucleolar RNA host gene 3 (SNHG3) is a key regulator of breast cancer progression. We analyzed RNA sequencing data to explore abnormally expressed lncRNAs in breast cancer. The effects of SNHG3 on breast cancer were investigated via in vitro and in vivo assays (CCK-8 assay, colony formation assay, flow cytometry assay, EdU assay, xenograft model, immunohistochemistry, and Western blot). The mechanism of SNHG3 action was explored through bioinformatics, RNA fluorescence in situ hybridization, luciferase reporter assay, RNA pull-down assay, chromatin immunoprecipitation assay and RNA immunoprecipitation assay. We found that SNHG3 expression was upregulated in breast cancer tissues and that its high expression level was associated with poor survival. We also found that high SNHG3 expression was partly induced by STAT3. Moreover, SNHG3 knockdown significantly repressed breast cancer cell growth both in vitro and in vivo. In the cytoplasm, SNHG3 facilitated the expression of Casein kinase II-A1 (CSNK2A1) by absorbing miR-485-5p and recruiting the HuR protein, participating in the malignant progression of breast cancer. Taken together, our study reveals a SNHG3-based regulatory network, which plays an oncogenic role in breast cancer and suggests that SNHG3 may serve as a potential target for the diagnosis and treatment of breast cancer.
Nationwide epidemiologic and genetic surveillance of hepatitis E in Japan, 2014–2021

Hepatitis E virus (HEV) is an emerging causative agent of acute hepatitis. To clarify the epidemiology of HEV and characterize the genetic diversity of the virus in Japan, nationwide enhanced surveillance and molecular characterization studies of HEV in Japan were undertaken from 2014 to 2021. In total, 2770 hepatitis E cases were reported, of which 88% were domestic cases, while only 4.1% represented cases following infection abroad. In addition, 57% of domestic infections occurred in males aged in their 40s–70s. For domestic cases, infection via pork meat consumption continued to be the most reported route. Analysis of the 324 sequences detected between 2016 and 2021 showed that the majority of domestic HEV strains belong to Genotype 3a (G3a) and G3b. In contrast, six of eight cases of G1 HEV reflected infection abroad. Our results suggest that HEV is circulating widely in Japan, with genotypes G3a and G3b being most prevalent. Continued surveillance is necessary to monitor future trends and changes in the epidemiology of HEV in Japan.
Walking ability of individuals fitted with transfemoral bone-anchored prostheses: A comparative study of gait parameters

Objective This study presents the walking abilities of participants fitted with transfemoral bone-anchored prostheses using a total of 14 gait parameters. Design Two-centre retrospective cross-sectional comparative study. Setting Research facilities equipped with tridimensional motion capture systems. Participants Two control arms included eight able-bodied participants arm (54 ± 9 years, 1.75 ± 0.07 m, 76 ± 7 kg) and nine participants fitted with transfemoral socket-suspended prostheses arm (59 ± 9 years, 1.73 ± 0.07 m, 80 ± 16 kg). The intervention arm included nine participants fitted with transfemoral bone-anchored prostheses arm (51 ± 13 years, 1.78 ± 0.09 m, 87.3 ± 16.1 kg). Intervention Fitting of transfemoral bone-anchored prostheses. Main measures Comparisons were performed for two spatio-temporal, three spatial and nine temporal gait parameters. Results The cadence and speed of walking were 107 ± 6 steps/min and 1.23 ± 0.19 m/s for the able-bodied participants arm, 88 ± 7 steps/min and 0.87 ± 0.17 m/s for the socket-suspended prosthesis arm, and 96 ± 6 steps/min and 1.03 ± 0.17 m/s for bone-anchored prosthesis arm, respectively. Able-bodied participants and bone-anchored prosthesis arms were comparable in age, height, and body mass index as well as cadence and speed of walking, but the able-bodied participant arm showed a swing phase 31% shorter. Bone-anchored and socket-suspended prostheses arms were comparable for age, height, mass, and body mass index as well as cadence and speed of walking, but the bone-anchored prosthesis arm showed a step width and duration of double support in seconds 65% and 41% shorter, respectively. Conclusions Bone-anchored and socket-suspended prostheses restored equally well the gait parameters at a self-selected speed. This benchmark data provides new insights into the walking ability of individuals using transfemoral bionics bone-anchored prostheses.
Water wave control by submerged pitching porous plate

The feasibility of using a pitching porous plate to actively control water waves is investigated on the basis of the linearized wave theory. The two-dimensional (2D) problem is formulated to deal with a fully submerged porous plate, pitching about its middle point and scattering an incident monochromatic wave. The plate thickness is negligible in comparison with the water depth and the wavelength of the incident wave. The pitching amplitude is assumed to be small, while the frequency of pitching is kept the same as that of the incident wave. The porous flow through the plate is governed by Darcy's law. The method of matched eigenfunction expansions is used to analyze the reflected and transmitted waves as well as the wave force and moment on the porous plate. It is found that the heights of reflected and transmitted waves vary rapidly for small values of porous-effect parameter, which is a direct measure of the porosity effect to the incident wave. A small value of porous-effect parameter is found to be o.
The PD Reflects Selection of Nontarget Locations, Not Distractor Suppression

Abstract In visual search tasks, negative features provide information about stimuli that can be excluded from search. It has been shown that these negative features help participants to locate the target, possibly by attentional suppression of stimuli sharing the negative feature. Attentional suppression is assumed to be reflected in an event-related potential, the PD component. To provide a further test of these assumptions, we presented the color of the distractor at the start of a trial and asked participants to find the other colored stimulus in the subsequent search display. Consistent with attentional suppression, we observed a PD to a lateral distractor shown with a vertical target. However, the PD occurred in this condition only when target and distractor could also be on opposite sides of fixation. The effect of trial context on the PD suggests that the PD reflects a search strategy whereby participants select stimuli opposite to the distractor when trials with opposite placements occur during the experiment. Therefore, the PD to the distractor may in fact be an N2pc to the opposite stimulus, indicating that the distractor is not suppressed, but avoided by redirecting attentional selection to the opposite side.
Global challenges in access to diagnostics and treatment for neuroendocrine tumor (NET) patients

SCAN, an online survey, measured access to diagnosis, treatments and monitoring of neuroendocrine tumor (NET) patients globally. Between September and November 2019, NET patients and healthcare professionals (HCPs) completed an online, semi‐standardized survey with 54 patient questions and 33 HCP questions. A total of 2359 patients with NETs and 436 HCPs responded. Misdiagnosis was common (44% [1043/2359]). Mean time to diagnosis was 4.8 years (standard deviation [SD], 6.2). Compared with global figures (60% [1407/2359]), the availability of 68Ga‐DOTA positron emission tomography (PET)/computed tomography (CT) was significantly lower in Asia (45% [126/280]) and higher in Oceania (86% [171/200]). HCPs reported that 68Ga‐DOTA PET/CT was free/affordable to fewer patients in Emerging and Developing Economies (EDE) than Advanced Economies (AE; 17% [26/150] and 59% [84/142], respectively). Compared with global data (52% [1234/2359]), patient‐reported availability of peptide receptor radionuclide therapy (PRRT) was significantly lower in Asia (31% [88/280]) and higher in Oceania (61% [122/200]). Significant differences were observed in average annual NET specialist costs between AE and EDE ($1081 and $2915, respectively). Compared with AE, patients in EDE traveled further for NET specialists (1032 [SD, 1578] and 181 [SD, 496] km, respectively). Patients and HCPs both recommended referral to HCPs that were more knowledgeable in the field of NETs and had better access to NET experts/specialist centers. National care pathways, enhancing HCP NET knowledge and ensuring effective diagnostics and access to appropriate treatments are crucial to improving patient survival and NET care worldwide.
Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients

Abstract The association between endometriosis and autoimmune diseases is well known, however no acquired platelet function defect has been described so far. We describe the case of two patients with endometriosis associated with an antiplatelet glycoprotein VI (anti-GPVI) antibody. The two women with deep pelvic endometriosis associated with secondary infertility presented a mild bleeding tendency, a deficient platelet aggregation response to collagen, convulxin or CRP and a severe GPVI deficiency. Immunoblot revealed a combined FcRγ deficiency but no indication of GPVI cleavage. In the first case, platelet count was normal and an anti-GPVI IgG was detected in plasma. A first corticosteroids administration normalized in vitro platelet functions but further administrations were unsuccessful. Three IVF attempts failed. Conservative laparoscopic surgery was carried out after antifibrinolytic treatment without bleeding. The second case presented with a history of moderate thrombocytopenia and a weak anti-GPVI in the context of infertility and autoimmune disease, the Sjögren syndrome resolved after corticosteroids and hydroxychloroquine treatment. Acquired GPVI deficiencies are rare. It would be useful to determine whether the association with endometriosis is coincidental or not by more systematic investigations. It does not seem that in these patients, GPVI deficiency is associated with an increased risk of bleeding. Plain Language Summary What is the context? • Evidence for an immune system dysfunction is reported in endometriosis and the association between endometriosis and autoimmune diseases is well known. • No autoimmune platelet function defect has been described so far. What is new? • We report two unrelated patients with endometriosis-associated infertility presenting a platelet glycoprotein VI deficiency due to an autoantibody. • In both cases, a deficient platelet aggregation response to collagen, convulxin or CRP and a severe GPVI deficiency were observed. • Immunoblot revealed no indication of GPVI cleavage. What is the impact? • Our observation raises the question whether GPVI could be a preferential target for the development of anti-GPVI autoantibodies associated with endometriosis. • It does not seem that in these patients, GPVI deficiency is associated with an increased risk of severe bleeding disorder.
Lacking a Formal Concept of Limit: Advanced Non-Mathematics Students’ Personal Concept Definitions

Abstract This mixed-methods study examines the conceptual understanding of limit among 22 undergraduate engineering students from two different sections of the same introductory differential equations course. The participants’ concepts of limit (concept images and personal concept definitions) were examined using written tasks followed by one-on-one investigative interviews. The findings suggest that, at the end of their mathematics coursework, many engineering students do not consider employing a formal definition of limit to solve limit-based mathematics problems. Furthermore, the findings suggest that most participants’ personal concept definitions of limit are both inoperable for solving limit problems and inconsistent with the formal definition of limit.
CSF proteomics in autosomal dominant Alzheimer’s disease highlights parallels with sporadic disease

Autosomal dominant Alzheimer’s disease (ADAD) offers a unique opportunity to study pathophysiological changes in a relatively young population with few comorbidities. A comprehensive investigation of proteome changes occurring in ADAD could provide valuable insights into AD‐related biological mechanisms and uncover novel biomarkers and therapeutic targets. Furthermore, ADAD might serve as a model for sporadic AD, but in‐depth proteome comparisons are lacking. We aimed to identify dysregulated CSF proteins in ADAD and determine the degree of overlap with sporadic AD.
Non-obstructive CAD and Risk of All-cause Mortality in Middle-aged and Older Patients: a Nine-Year Follow-up and Multicentre Study.

AIM We aimed to examine all-cause mortality risk in relation to the extent of non-obstructive coronary artery disease (CAD) by coronary computed tomography angiography (CTA) in Chinese middle-aged and older patients in a multicenter study with nine-year follow-up. METHODS This was a retrospective, observational, multicentre study. The study population consisted of 3,240 consecutive middle-aged and older patients (age ≥ 40 years) with suspected CAD who underwent coronary CTA between June 2011 and December 2013 at three hospitals in Wuhan, China. Patients were grouped according to CAD extent for the final analysis: no CAD, 1-vessel non-obstructive CAD, 2-vessels non-obstructive CAD, and 3-vessels non-obstructive CAD. The primary endpoint was all-cause mortality. Kaplan-Meier method and Cox proportional hazards regression models were used for analysis. RESULTS A total of 2,522 patients were included in the present analysis. Of these, 188 (7.5%) deaths occurred during the median 9.0 years (interquartile range 8.6-9.4) of study follow-up. The annualized all-cause mortality rate was 0.54 (95% CI: 0.44-0.68), 0.91 (95% CI: 0.68-1.21), 1.44 (95% CI: 1.01-1.93), and 2.00 (95% CI: 1.46-2.69) for the no CAD, 1-vessel non-obstructive CAD, 2-vessels non-obstructive CAD, and 3-vessels non-obstructive CAD group, respectively. Kaplan-Meier survival curves showed a significant increase in the cumulative events associated with the extent of non-obstructive CAD (P < 0.001). In multivariate Cox regression, after adjustment for age and sex, the presence of 3-vessels non-obstructive CAD was a significant predictor of all-cause mortality (HR 1.60, 95% CI: 1.04-2.45, P = 0.032). CONCLUSION In this cohort of Chinese middle-aged and older patients undergoing coronary CTA, the presence and extent of non-obstructive CAD, compared to no CAD, were associated with a significantly greater nine-year risk of all-cause mortality. The present findings suggest the clinical importance of the stage of non-obstructive CAD and warrant investigation of the optimal risk stratification to improve outcomes among these patients.
Facebook Addiction and High School Students’ Sleep Quality: The Serial Mediation of Procrastination and Life Satisfaction and the Moderation of Self-Compassion

Abstract A growing body of research has indicated that Facebook addiction is a salient risk factor for sleep quality among high school students. This study examined whether procrastination and life satisfaction serially mediate the relationship between Facebook addiction and sleep quality and whether this mediating process is moderated by self-compassion. This research uses quantitative research approach to examine Facebook addiction, procrastination, life satisfaction, sleep quality, and self-compassion, in the sample of 280 Vietnamese high school students (Mage = 16.75 years, SD = .0825). Facebook addiction was not significantly associated with sleep quality among high school students. The serial mediator role of procrastination and life satisfaction on the pathway from Facebook addiction to sleep quality was not significant. Moderated mediation analysis further revealed that self-compassion moderated the association between Facebook addiction and high school students’ sleep quality. These findings elucidate the role of Facebook addiction, procrastination, and self-compassion in high school students’ sleep quality. Furthermore, they suggest that self-compassion intervention programs may be promising to reduce procrastination, Facebook addiction, as well as to enhance sleep quality and life satisfaction for high school students.
Striatonigrostriatal connectivity‐based cross‐species parcellation of human and macaque substantia nigra

Anatomical and functional heterogeneous substantia nigra (SN) has been extensively studied in humans and animals like rhesus monkeys given its crucial role in modulating a broad range of behaviors. Increasingly important cross‐species research of SN may require connectionally homogeneous and homologous subregions of SN as objective and stable starting points from which the evolutionary characteristics of brain could be inspected. However, existing atlases of SN were all inaccurate mappings as a cross‐species connectome atlas due to inadequate homology constraint during their constructions, and arbitrary paired use of these atlases might cause unreliable findings. In this study, a reliable blind‐source cross‐species parcellation of SN was developed based on the following rationale: striatonigrostriatal circuits form major structure of nigral connectivity; different nigral components have unique striatonigrostriatal connectivity; and inter‐species corresponding human and macaque nigral components have similar striatonigrostriatal connectivity. Specifically, all voxels in human and macaque SN were grouped together and then classified based on inter‐species identically characterized striatonigrostriatal connectivity attributes. Our results delineated a pars compacta‐pars reticulate‐like parcellation and further demonstrated its reliability by illustrating best‐matched whole‐brain structural and functional connectivity profiles of inter‐species corresponding nigral subregions. Detailed inter‐species and inter‐regional differences in multi‐aspect connectivities of these nigral subregions were inspected. It is expected that this cross‐species connectome atlas of SN can offer biologically reliable cornerstones and important information to facilitate future cross‐species research.
Metabolic adaptation to consume butyrate under prolonged resource exhaustion

Bacteria must often survive following the exhaustion of their external growth resources. Fitting with this need, many bacterial species that cannot sporulate, can enter a state known as long term stationary phase (LTSP) in which they can persist for years within spent media. Several recent studies have revealed the dynamics of genetic adaptation of Escherichia coli under LTSP. Yet, the metabolic consequences of such genetic adaptation were not addressed. Here, we characterized the metabolic changes LTSP populations experience, over the first 32 days under LTSP. This allowed us to link genetic adaptations observed in a convergent manner across LTSP populations back to their metabolic adaptive effect. Specifically, we demonstrate that through the acquisition of mutations combinations in specific sets of metabolic genes, E. coli acquires the ability to consume the short chain fatty acid butyrate. Intriguingly, this fatty acid is not initially present within the rich media we used in this study. Instead, it is E. coli itself that produces butyrate during its initial growth within fresh rich media. The mutations that enable butyrate consumption allow E. coli to grow on butyrate. However, the clones carrying these mutations rapidly decrease in frequency, once the butyrate is consumed, likely reflecting an associated cost to fitness. Yet despite this, E. coli populations show a remarkable capability of maintaining these genotypes at low frequency, as standing variation. This in turn allows them to more rapidly re-adapt to consume butyrate, once it again becomes available to them.
Predicting diabetic foot ulceration using routinely collected data in a foot clinic. What level of prognostic accuracy can be achieved?

This study aimed to investigate the efficacy of using routinely collected clinical data in predicting the risk of diabetic foot ulcer (DFU). The first objective was to develop a prognostic model based on the most important risk factors objectively selected from a set of 39 clinical measures. The second objective was to compare the prediction accuracy of the developed model against that of a model based on only the 3 risk factors that were suggested in the systematic review and meta‐analyses study (PODUS). In a cohort study, a set of 12 continuous and 27 categorical data from patients (n = 203 M/F:99/104) who attended a specialised diabetic foot clinic were collected at baseline. These patients were then followed‐up for 24 months during which 24 (M/F:17/7) patients had DFU. Multivariate logistic regression was used to develop a prognostic model using the identified risk factors that achieved p < 0.2 based on univariate logistic regression. The final prognostic model included 4 risk factors (Adjusted‐OR [95% CI]; p) in total. Impaired sensation (116.082 [12.06–1117.287]; p = 0.000) and presence of callus (6.257 [1.312–29.836]; p = 0.021) were significant (p < 0.05), while having dry skin (5.497 [0.866–34.89]; p = 0.071) and Onychomycosis (6.386 [0.856–47.670]; p = 0.071) that stayed in the model were not significant. The accuracy of the model with these 4 risk factors was 92.3%, where sensitivity and specificity were 78.9%, and 94.0% respectively. The 78.9% sensitivity of our prognostic 4‐risk factor model was superior to the 50% sensitivity that was achieved when the three risk factors proposed by PODUS were used. Also our proposed model based on the above 4 risk factors showed to predict the DFU with higher overall prognostic accuracy. These findings have implications for developing prognostic models and clinical prediction rules in specific patient populations to more accurately predict DFU.