Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Safety Climate on Safety Behaviour: the Mediating Role of Safety Motivation and Safety Knowledge

Safety behavior is an important element in maintaining safety and preventing accidents. This study aims to analyze the effect of the safety climate on safety behavior through safety motivation and safety knowledge as mediating variables. Type of this research is explanatory research with a quantitative approach. The population of this research is the crew machinist of PT. KeretaApi Indonesia (Persero), amounting to 3000 machinists with the sampling technique using purposive sampling with a sample size of 100 respondents. The data collection method used a questionnaire. The data analysis method used is the path analysis method using the Smart PLS tool. The partial results of hypothesis testing of the safety climate have a positive and significant effect on safety motivation. The safety climate has a positive and significant effect on safety knowledge. The safety climate has a positive and significant effect on safety behavior. Safety motivation has a positive and significant effect on safety behavior. Safety knowledge has a positive and significant effect on safety behavior. The results of testing the indirect effect of using or mediation found that safety motivation and safety knowledge were able to mediate the effect of safety climate on safety behavior
Surveillance of mycotoxin contaminants and mycotoxigenic fungi in agricultural produce

Food crops, including vegetables, are prone to attack by pathogenic and mycotoxigenic fungi and represent a food safety and public health risk. The study aimed to detect and quantify mycotoxins in vegetables widely consumed in Mauritius. Diseased samples of garlic, onion, potato, pumpkin and tomato were collected post-harvest. Following microscopic identification of the suspect pathogen(s), samples were tested for mycotoxins by ELISA. Results demonstrated a high mean level of citrinin in garlic (5,448.6 μg/kg) and ochratoxin in onion (9.25 μg/kg), which exceeded the permissible limits, thus pointing to potential health risks associated with the consumption of these vegetables.
Association between activities of daily living and depressive symptoms among older adults in China: evidence from the CHARLS

Objective The limitation of activities of daily living (ADL) affects the mental health of older adults. We distinguished activities of daily living into basic activities of daily living (BADL) and instrumental activities of daily living (IADL) and aimed to explore the relationship between the two limitations and depressive symptoms among Chinese older adults by using nationally representative cross-sectional data. Methods Data from the China Health and Retirement Longitudinal Study (CHARLS, wave 4) were used, and 9,789 older adults aged 60 years and above were screened. The 10-item Center for Epidemiologic Studies Depression (CES-D-10) scale was used to measure the depressive symptoms of older adults, and a 12-item scale for ADL was used to estimate functional limitations. Generalized linear mixed-effect models were employed to examine the relationship between BADL/IADL and depressive symptoms among older adults. Results The prevalence of high-risk depression among older adults was 43.5%, and the rates of limitation in BADL and IADL were 19.02 and 25.29%, respectively. The prevalence of high-risk depression significantly differed among subgroups of smoking, drinking, chronic diseases, duration of sleep, having social activities or not, and the type of medical insurance. Older adults with limited BADL or IADL were at a higher risk of depression than those without limitations of BADL or IADL; BADL (OR-adjusted = 2.71; 95% CI: 2.40–3.06) and IADL (OR-adjusted = 2.68; 95% CI: 2.41–2.98) had various influences on the risk of depression in older adults. Conclusion ADL was a related factor in the risk of depression among older adults in China. BADL and IADL had different effects on the risk of depression, suggesting that older adults with physical function limitations might be more likely to suffer from depression.
Cold dense ion flows with multiple components observed in the distant tail lobe by Geotail

The Geotail spacecraft frequently observes cold dense ion flows (CDIFs) streaming tailward in the magnetotail lobe region (XGSM∼−10 to −210 RE). The density is often quite high (∼1/cm3), comparable to or larger than that in the plasma sheet, and the tailward speed is from 50 to 500 km/s. The CDIFs sometimes contain multiple (two or three) energy-per-charge components. The lowest- and highest-energy components are identified as H+ and O+, respectively. The intermediate-energy component is identified as He+. Therefore a part of the CDIFs in the distant lobes is believed to be of ionospheric origin. A possible source candidate is the upward flowing ions (UFIs) outgoing from the dayside auroral region or polar wind escaping from the polar cap and accelerated along the magnetic field direction. The high proton to O+ density ratio in the CDIFs suggests that the major component of the CDIFs originates from the solar wind and that the cold ion beams of ionospheric origin merge with the solar wind component penetrating into the magnetosphere at the mantle or the flank of the tail lobe. In some observations, the H+ ions continuously stream tailward both in the tail lobe and in the magnetosheath, and they couple with the solar wind ions through the magnetopause. Although the O+ and He+ ion flows cannot be recognized so clearly in the magnetosheath, weak O+ fluxes are sometimes present in the magnetosheath near the magnetopause. This implies that plasma of ionospheric origin may leak from the tail to the magnetosheath. The multicomponent CDIF events make it possible to discuss the sources and transport processes of the tail lobe plasma, and their behavior in or near the magnetopause provides important clues to the interactions between the lobe and the magnetosheath.
Willingness to pay for improvements in drinking water quality

In this paper, data from a 1991 survey of Georgia residents were used to study people's willingness to pay (WTP) for improvements in drinking water quality and people's perceptions of potential groundwater contamination. Results showed that 27% of the respondents served by public water supplies rated drinking water quality as poor, and 23% were uncertain about their drinking water quality. The contingent valuation method was used to estimate WTP using a checklist format. The median estimated WTP was $5.49 per month above their current water bills for people on public systems and $7.38 for those using private wells, after rejecting outliers and using the maximum likelihood method. The aggregate WTP for all of Georgia was estimated to be about $111.5 million per year for public water users and $42.3 million per year for private well owners. This aggregate WTP can serve as an estimate of benefits to consumers from improvements in drinking water quality statewide.
Characteristics of health and well-being in former Jehovah’s Witnesses in Austria, Germany, and Switzerland

ABSTRACT Background: This study collected quantifiable data on the characteristics, health, and well-being of individuals who left or were expelled from a fundamentalist Christian faith community in Austria, Germany, or Switzerland. Methods: Data were collected using an online survey. Results: This study assessed a sample of former Jehovah’s Witnesses (N = 424, M age = 42.14, SD age = 12.57, 65% female). Most participants (66%) were born into this faith community. Half the sample left voluntarily, 21% were expelled, and 31% left due to having experienced abuse or maltreatment. One third reported suicidal thoughts; 10% had attempted suicide. The sample (especially women) reported relatively high levels of child maltreatment, moderate current health, clinically significant symptoms, high levels of stress, and low quality of life. Participants who left due to abuse or maltreatment reported more symptoms and child maltreatment. Discussion: Women and survivors of child maltreatment may represent particularly vulnerable sub-groups of former Jehovah’s Witnesses.
The Combination of Radiation with PARP Inhibition Enhances Senescence and Sensitivity to the Senolytic, Navitoclax, in Triple Negative Breast Tumor Cells

Despite significant advances in the treatment of triple-negative breast cancer, this disease continues to pose a clinical challenge, with many patients ultimately suffering from relapse. Tumor cells that recover after entering into a state of senescence after chemotherapy or radiation have been shown to develop a more aggressive phenotype, and to contribute to disease recurrence. By combining the PARP inhibitor (PARPi), talazoparib, with radiation, senescence was enhanced in 4T1 and MDA-MB-231 triple-negative breast cancer cell lines (based on SA-β-gal upregulation, increased expression of CDKN1A and the senescence-associated secretory phenotype (SASP) marker, IL6). Subsequent treatment of the radiation- and talazoparib-induced senescent 4T1 and MDA-MB231 cells with navitoclax (ABT-263) resulted in significant apoptotic cell death. In immunocompetent tumor-bearing mice, navitoclax exerted a modest growth inhibitory effect when used alone, but dramatically interfered with the recovery of 4T1-derived tumors induced into senescence with ionizing radiation and talazoparib. These findings support the potential utility of a senolytic strategy in combination with the radiotherapy/PARPi combination to mitigate the risk of disease recurrence in triple-negative breast cancer.
Crestal and Subcrestal Placement of Morse Cone Implant–Abutment Connection Implants: An In Vitro Finite Element Analysis (FEA) Study

The issue of dental implant placement relative to the alveolar crest, whether in supracrestal, equicrestal, or subcrestal positions, remains highly controversial, leading to conflicting data in various studies. Three-dimensional (3D) Finite Element Analysis (FEA) can offer insights into the biomechanical aspects of dental implants and the surrounding bone. A 3D model of the jaw was generated using computed tomography (CT) scans, considering a cortical thickness of 1.5 mm. Subsequently, Morse cone implant–abutment connection implants were virtually positioned at the model’s center, at equicrestal (0 mm) and subcrestal levels (−1 mm and −2 mm). The findings indicated the highest stress within the cortical bone around the equicrestally placed implant, the lowest stress in the −2 mm subcrestally placed implant, and intermediate stresses in the −1 mm subcrestally placed implant. In terms of clinical relevance, this study suggested that subcrestal placement of a Morse cone implant–abutment connection (ranging between −1 and −2 mm) could be recommended to reduce peri-implant bone resorption and achieve longer-term implant success.
Targeting Epigenetic Regulators with HDAC and BET Inhibitors to Modulate Muscle Wasting

Epigenetic changes contribute to the profound alteration in the transcriptional program associated with the onset and progression of muscle wasting in several pathological conditions. Although HDACs and their inhibitors have been extensively studied in the field of muscular dystrophies, the potential of epigenetic inhibitors has only been marginally explored in other disorders associated with muscle atrophy, such as in cancer cachexia and sarcopenia. BET inhibitors represent a novel class of recently developed epigenetic drugs that display beneficial effects in a variety of diseases beyond malignancies. Based on the preliminary in vitro and preclinical data, HDACs and BET proteins contribute to the pathogenesis of cancer cachexia and sarcopenia, modulating processes related to skeletal muscle mass maintenance and/or metabolism. Thus, epigenetic drugs targeting HDACs and BET proteins may emerge as promising strategies to reverse the catabolic phenotype associated with cachexia and sarcopenia. Further preclinical studies are warranted to delve deeper into the molecular mechanisms associated with the functions of HDACs and BET proteins in muscle atrophy and to establish whether their epigenetic inhibitors represent a prospective therapeutic avenue to alleviate muscle wasting.
Cytochrome P450 2D6 profiles and anti-relapse efficacy of tafenoquine against Plasmodium vivax in Australian Defence Force personnel

ABSTRACT Plasmodium vivax infections and relapses remain a major health problem for malaria-endemic countries, deployed military personnel, and travelers. Presumptive anti-relapse therapy and radical cure using the 8-aminoquinoline drugs primaquine and tafenoquine are necessary to prevent relapses. Although it has been demonstrated that the efficacy of primaquine is associated with Cytochrome P450 2D6 (CYP2D6) activity, there is insufficient data on the role of CYP2D6 in the anti-relapse efficacy of tafenoquine. We investigated the relationship between CYP2D6 activity status and tafenoquine efficacy in preventing P. vivax relapses retrospectively using plasma samples collected from Australian Defence Force personnel deployed to Papua New Guinea and Timor-Leste who participated in clinical trials of tafenoquine during 1999–2001. The CYP2D6 gene was amplified from plasma samples and fully sequenced from 92 participant samples, comprised of relapse (n = 31) and non-relapse (n = 61) samples, revealing 14 different alleles. CYP2D6 phenotypes deduced from combinations of CYP2D6 alleles predicted that among 92 participants 67, 15, and 10 were normal, intermediate, and poor metabolizers, respectively. The deduced CYP2D6 phenotype did not correlate with the corresponding participant’s plasma tafenoquine concentrations that were determined in the early 2000s by high-performance liquid chromatography or liquid chromatography-mass spectrometry. Furthermore, the deduced CYP2D6 phenotype did not associate with P. vivax relapse outcomes. Our results indicate that CYP2D6 does not affect plasma tafenoquine concentrations and the efficacy of tafenoquine in preventing P. vivax relapses in the assessed Australian Defence Force personnel.
Discourse-pragmatic functions of wellah and wellahi in spoken Kurdish

This study explores the discourse-pragmatic functions of the lexical items wellah and wellahi by twenty-four Iraqi Kurdish-speaking adults (24 first and fourth-year undergraduate students). All the participants studied in the English department at the University of Raparin in Kurdistan. As a qualitative research, Brinton’s (1996) binary classification is adopted as a theoretical framework in defining the functions wellah and wellahi have at the textual and interpersonal levels. Using empirical data, five individual functions related to the use of wellah and wellahi: including three textual functions (elaboration, filler and; topic shift) and two interpersonal ones (response marker [politeness marker] and confirmation marker) are demonstrated. Throughout, the findings link to those identified in previous Arabic studies. The data analysis demonstrates that the use of wellahi in Kurdish is similar to its use in Arabic. In addition, the current study indicates that both wellah and wellahi function as discourse markers interchangeably in most of the cases. The results suggest that principles of grammaticalisation, such as phonetic-reduction and layering, could explain the development of interchangeability of the discourse markers. This study contributes to our understanding of the pragmatics of Kurdish language, the functions of discourse markers, language variation and grammaticalisation
Automatic Segmentation and Assessment of Valvular Regurgitations with Color Doppler Echocardiography Images: A VABC-UNet-Based Framework

This study investigated the automatic segmentation and classification of mitral regurgitation (MR) and tricuspid regurgitation (TR) using a deep learning-based method, aiming to improve the efficiency and accuracy of diagnosis of valvular regurgitations. A VABC-UNet model was proposed consisting of VGG16 encoder, U-Net decoder, batch normalization, attention block and deepened convolution layer based on the U-Net backbone. Then, a VABC-UNet-based assessment framework was established for automatic segmentation, classification, and evaluation of valvular regurgitations. A total of 315 color Doppler echocardiography images of MR and/or TR in an apical four-chamber view were collected, including 35 images in the test dataset and 280 images in the training dataset. In comparison with the classic U-Net and VGG16-UNet models, the segmentation performance of the VABC-UNet model was evaluated via four metrics: Dice, Jaccard, Precision, and Recall. According to the features of regurgitation jet and atrium, the regurgitation could automatically be classified into MR or TR, and evaluated to mild, moderate, moderate–severe, or severe grade by the framework. The results show that the VABC-UNet model has a superior performance in the segmentation of valvular regurgitation jets and atria to the other two models and consequently a higher accuracy of classification and evaluation. There were fewer pseudo- and over-segmentations by the VABC-UNet model and the values of the metrics significantly improved (p < 0.05). The proposed VABC-UNet-based framework achieves automatic segmentation, classification, and evaluation of MR and TR, having potential to assist radiologists in clinical decision making of the regurgitations in valvular heart diseases.
Late Quaternary volcanic activity in Marie Byrd Land: Potential 40Ar/39Ar-dated time horizons in West Antarctic ice and marine cores

Late Quaternary volcanic activity at three major alkaline composite volcanoes in Marie Byrd Land, West Antarctica, is dominated by explosive eruptions, many capable of depositing ash layers as regional time-stratigraphic horizons in the West Antarctic Ice Sheet and in Southern Ocean marine sediments. A total of 20 eruptions at Mount Berlin, Mount Takahe, and Mount Siple are recorded in lava and welded and nonwelded pyroclastic fall deposits, mostly peralkaline trachyte in composition. The eruptions, dated by the 40Ar/39Ar laser-fusion and furnace step-heating methods, range in age from 571 to 8.2 ka. Tephra from these 40Ar/39Ar-dated Marie Byrd Land eruptions are identified by geochemical fingerprinting in the 1968 Byrd Station ice core. The 74 ka ice-core record contained abundant coarse ash layers, with model ice-flow ages ranging from 7.5 to 40 ka, all of which were previously geochemically correlated to the Mount Takahe volcano. We identify a one-to-one geochemical and age correlation of the youngest (ca. 7.5 ka) tephra layer in the Byrd ice core to an 8.2 ± 5.4 ka (2sigma uncertainty) pyroclastic deposit at Mount Takahe. We infer that the 20–30 ka tephra layers in the Byrd ice core actually were erupted from Mount Berlin, on the basis of age and geochemical similarities. If products of these youngest, as well as the older 40Ar/39Ar-dated eruptions are identified by geochemical fingerprinting in future ice and marine cores, they will provide the cores with independently dated time horizons. More than 12 40Ar/39Ar-dated tephra layers, exposed in bare ice on the summit ice cap of Mount Moulton, 30 km from their inferred source at Mount Berlin, range in age from 492 to 15 ka. These englacial tephra layers provide a minimum age of 492 ka for the oldest isotopically dated ice in West Antarctica. This well-dated section of locally derived glacial ice contains a potential “horizontal ice core” record of paleoclimate that extends back through several glacial-interglacial cycles. The coarse grain size and density of the englacial tephra (mean diameters 17–18 mm, densities 540–780 kg/m3), combined with their distance from source, indicate derivation from highly explosive Plinian eruptions of Mount Berlin.
Enhancing SSVEP Identification With Less Individual Calibration Data Using Periodically Repeated Component Analysis

Objective: Spatial filtering and template matching-based steady-state visually evoked potentials (SSVEP) identification methods usually underperform in SSVEP identification with small-sample-size calibration data, especially when a single trial of data is available for each stimulation frequency. Methods: In contrast to the state-of-the-art task-related component analysis (TRCA)-based methods, which construct spatial filters and SSVEP templates based on the inter-trial task-related components in SSVEP, this study proposes a method called periodically repeated component analysis (PRCA), which constructs spatial filters to maximize the reproducibility across periods and constructs synthetic SSVEP templates by replicating the periodically repeated components (PRCs). We also introduced PRCs into two improved variants of TRCA. Performance evaluation was conducted in a self-collected 16-target dataset, a public 40-target dataset, and an online experiment. Results: The proposed methods show significant performance improvements with less training data and can achieve comparable performance to the baseline methods with 5 trials by using 2 or 3 training trials. Using a single trial of calibration data for each frequency, the PRCA-based methods achieved the highest average accuracies of over 95% and 90% with a data length of 1 s and maximum average information transfer rates (ITR) of 198.8±57.3 bits/min and 191.2±48.1 bits/min for the two datasets, respectively. Averaged online accuracy of 94.00 ± 7.35% and ITR of 139.73±21.04 bits/min were achieved with 0.5-s calibration data per frequency. Significance: Our results demonstrate the effectiveness and robustness of PRCA-based methods for SSVEP identification with reduced calibration effort and suggest its potential for practical applications in SSVEP-BCIs.
Macroeconomic Risks and Monetary Policy in Central European Countries: Parallels in the Czech Republic, Hungary, and Poland

Changes in interest rates, inflation, and exchange rates are the main components of macroeconomic risks (financial risks) in projects evaluation. However, the conduct of monetary policy as well as its impact on the economic environment is seldom considered as an important component of macroeconomic risks. In this paper, we offer a simple framework to analyze the conduct of monetary policy. We examine the stabilizing properties of monetary policy, its impact, and the parallels in the monetary policy approaches taken in the Czech Republic, Hungary, and Poland until the pandemic. We provide a simple theoretical background to motivate the main elements of the debate and the choice of policy strategy. We then rationalize the adoption of a form of flexible inflation targeting (FIT). It is characterized by an explicit concern over exchange rates. The empirical evidence, consisting of calibrated and extended Taylor rules, together with local projections estimates, suggests that monetary policy has been practiced with considerable flexibility by all three central banks and has contributed to business cycle stabilization in the region. Most notably, the exchange rate plays an important role in the conduct of monetary policy.