Miracle-dz/UniFAR-FTUs huggingface dataset:
MOLPHARM-AR-2023-000787R Inhibition of cardiac Kv4.3/KChIP2 channels by a sulfonylurea drug gliquidone

The Kv4.3 channel is featured of fast N-type inactivation and also undergoes a slow C-type inactivation. The gain-of-function mutations of Kv4.3 channels cause an inherited disease called Brugada syndrome characterized by a shortened duration of cardiac action potential repolarization and ventricular arrhythmia. The
The Eco-Efficiency Premium Puzzle

Does socially responsible investing (SRI) lead to inferior or superior portfolio performance? This study focused on the concept of "eco-efficieticy," which can he thought of as the economic value a company creates relative to the waste it generates, and found that SRI produced superior performance. Based on Innovest Strategic Value Advisors' corporate eco-efficiency scores, the study constructed and evaluated two equity portfolios that differed in eco-efficiency. The high-ranked portfolio provided substantially higher average returns than its low-ranked counterpart over the 1995-2003 period. This performance differential could not he explained by differences in market sensitivity, investment style, or industry-specific factors. Moreover, the results remained significant for all levels of transaction costs, suggesting that the incremental benefits ofSRJ can be substantial.
Academic engagement and its impact on undergraduate student performance at the University of La Laguna

The attitude and involvement with which undergraduate university students approach their training process can have a significant impact on the academic results they obtain. The relationship that can occur between low involvement and the possibility of failing or dropping out of studies has led us to propose this research, where the relationship between engagement and academic performance is deepened. The engagement refers to the feeling of well-being of the students with respect to a challenge related to their training process. Students who are studying at university are exposed to living situations that make them more or less committed to their learning process, which can lead to obtain better or worse academic results. This ex-post-facto quantitative study, which was carried out with a sample of 564 first and second year students from the three degrees of the Faculty of Education of the University of La Laguna (Spain), aimed to analyze the relationship between academic commitment and performance in studies. The results reveal that students with higher scores in the different structural dimensions of academic commitment (vigor, dedication and absorption) have higher grades in the subjects they take. The discussion of the study focuses on the need to plan strategies to promote academic commitment in order to strengthen both the trajectories of adaptation and permanence in the degree and the achievement of better academic results in university students.
Agent-Centric State Discovery for Finite-Memory POMDPs

Discovering an informative, or agent-centric, state representation that encodes only the relevant information while discarding the irrelevant is a key challenge towards scaling reinforcement learning algorithms and efficiently applying them to downstream tasks. Prior works studied this problem in high-dimensional Markovian environments, when the current observation may be a complex object but is sufficient to decode the informative state. In this work, we consider the problem of discovering the agent-centric state in the more challenging high-dimensional non-Markovian setting, when the state can be decoded from a sequence of past observations. We establish that generalized inverse models can be adapted for learning agent-centric state representation for this task. Our results include asymptotic theory as well as negative results for alternative intuitive algorithms, such as encoding with only a forward-running sequence model. We complement these findings with a thorough empirical study on the agent-centric state discovery abilities of the different alternatives we put forward. Particularly notable is our analysis of past actions, where we show that these can be a double-edged sword: making the algorithms more successful when used correctly and causing dramatic failure when used incorrectly.
Mt. Etna Tilt Signals Associated with February 6, 2023, <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"><mi>M</mi><mo>=</mo><mn>7.8</mn></math> and <math xmlns="http://www.w3.org/1998/Math/MathML" id="M2"><mi>M</mi><mo>=</mo><mn>7.5</mn></math> Turkey Earthquakes

On February 6, 2023, at 01 : 17 UTC, a M=7.8 earthquake struck the southern area of Turkey near Gaziantep town and was followed by a second earthquake of M=7.5 at 10 : 24 UTC with the epicenter in Elbistan city. Both events were associated with the Anatolian Fault System and have claimed over 50,000 victims, as reported by the Disaster and Emergency Management Authority, and caused serious damage in the regions of southern Turkey and northern Syria. Seismic waves related to strong Turkey earthquakes have been recorded both by seismic stations throughout the globe and on other devices such as the ground deformation (GNSS, strainmeters, or tiltmeters) networks. In this paper, we show and analyze the earthquake signals recorded by bore-hole tilt stations that monitor seismic and volcanic activities at Mt. Etna. Tilt stations showed very large variations, despite their distance from the epicenter (approximately 1950 km) with a period between 10 and 25 seconds. We compared tilt and seismic data for a co–located station evidencing a very similar waveform that highlight how tiltmeters respond to translational acceleration rather than ground tilt during a teleseism, suggesting that, for waves with this period, they may behave as horizontal seismometers. By using these signals, we evidence the different behaviors of two of the most used models of tiltmeters on volcanoes (Lily and Pinnacle) and how they are useful for instrument calibration.
Evaluation of TRMM Multi-satellite Precipitation Analysis during the passage of Tropical Cyclones over Fiji

Fiji is prone to the devastating effects of heavy rainfall during the passage of tropical cyclones (TCs) and as such accurate measurement of rainfall during such events is urgent for effective disaster mitigation and risk analysis. Fiji, however, has a sparse distribution of rain gauges, thus there is a deficiency in the accurate measurement of rainfall. This gap could be filled by satellite-based rainfall estimates but before they are used, they need to be validated against a reference dataset for their accuracy and limitations. This study thus validates the TRMM based Multi-satellite Precipitation Analysis (TMPA) estimates over the island of Fiji. The study shows that TMPA has moderate skill in estimating rainfall during the passage of TCs over the island of Fiji. This skill is also highly variable as it decreases with an increase in rainfall intensity, increase in distance from the cyclone centre and increasing terrain elevation. The ability of TMPA also varies case by case but we report a general underestimation of rainfall by TMPA during the passage of TCs with a larger rainfall rate (defined in our case as those TCs with average daily rainfall greater than 25 mm day).
Understanding ozone‐meteorology correlations: A role for dry deposition

Observations of coincident high relative humidity and low surface ozone are common in air quality data sets, but models underpredict the strength of this correlation. We perform a statistical analysis of 28 years of ozone and meteorology observations taken as part of the Clean Air Status and Trends Network across the United States and find that vapor pressure deficit (VPD) is the strongest predictor of midday ozone in the spring, summer, and fall, and this correlation is strongest at sites with the largest leaf area index. We argue that stomatal regulation of dry deposition, which is known to have a VPD dependence that is not typically included in model parameterizations, can explain this relationship. Using a box model of ozone production and loss, we show that a negative ozone‐humidity slope is only achieved by the inclusion of VPD‐dependent dry deposition, suggesting that this mechanism may explain the observed ozone‐humidity correlation.
Contributing to urban resilience to floods with neighbourhood design: the case of Am Sandtorkai/Dalmannkai in Hamburg

On‐going changes in cities caused by rapid urbanisation and climate change have increased both the flood probability and the severity of flooding. Consequently, there is a need for all cities to adapt to climate and socio‐economic changes by developing new strategies for flood risk management. The following risk paradigm shifts from traditional to more integrated approaches, since one of the main emerging tasks for city managers is the development of resilient cities. The concept of resilience is becoming more and more important, despite the many challenges that interfere with its implementation. The goal of this research is to create knowledge on how to operationalise flood resilience at the neighbourhood level through neighbourhood design. A research approach was used and a qualitative analysis tool, the DS3 model, was developed in order to study a particular neighbourhood of HafenCity, in Hamburg. Results show that design measures involving transportation infrastructure, land use (open public spaces) and buildings have been the main contributions to the flood resilience of the neighbourhood.
How numbers of nesting sea turtles can be overestimated by nearly a factor of two

Estimating the absolute number of individuals in populations and their fecundity is central to understanding the ecosystem role of species and their population dynamics as well as allowing informed conservation management for endangered species. Estimates of abundance and fecundity are often difficult to obtain for rare or cryptic species. Yet, in addition, here we show for a charismatic group, sea turtles, that are neither cryptic nor rare and whose nesting is easy to observe, that the traditional approach of direct observations of nesting has likely led to a gross overestimation of the number of individuals in populations and underestimation of their fecundity. We use high-resolution GPS satellite tags to track female green turtles throughout their nesting season in the Chagos Archipelago (Indian Ocean) and assess when and where they nested. For individual turtles, nest locations were often spread over several tens of kilometres of coastline. Assessed by satellite observations, a mean of 6.0 clutches (range 2–9, s.d. = 2.2) was laid by individuals, about twice as many as previously assumed, a finding also reported in other species and ocean basins. Taken together, these findings suggest that the actual number of nesting turtles may be almost 50% less than previously assumed.
Modélisation des échanges convectifs dans le conduit utile d’un capteur solaire plan à air muni de rugosités artificielles de formes rectangulaires

Ce travail consiste à établir des modèles empiriques de calcul du coefficient d’échange thermique par convection, lors de l’écoulement de l’air dans un conduit utile rectangulaire d’un capteur solaire plan à air, dont le plan inférieur est muni de rugosités artificielles dites chicanes de formes rectangulaires disposées en quinconce. Par la méthode de l’analyse dimensionnelle, on a pu mettre en relation tous les paramètres physiques, thermophysiques et les caractéristiques géométriques des chicanes, en fonction du régime d’écoulement on estime un coefficient d’échange global par convection dans l’espace d’écoulement du fluide.
PREDICTORS OF LIFE QUALITY IN UNIVERSITY CAMPUSES: THE ROLE OF CAMPUS ATTACHMENT AND UNIVERSITY IDENTIFICATION

Many studies have shown that the positive emotional bond between people and places influences the well-being and life quality of individuals. Although this has been demonstrated by studies conducted in places of different scales, including neighborhoods and cities, evidence is needed to reveal how the university campus influences the quality of life of its students. So, the main aim of the current study is to figure out the role of university identification in the relationship between university campus attachment and life quality. A total of 296 university students (226 female, 68 male, 1 non-binary, 1 not stated) completed Group Identification Scale, University Place Attachment Scale and WHOQOOL-BREF-TR. A path analysis by using jamovi was carried out to test the effects of exogenous demographic variables on the endogenous variables. Findings demonstrated that sense of security in the campus and the satisfaction with the physical and social facilities of the campus positively predict campus attachment. In addition, our results suggested that university campus attachment has a positive indirect effect on the quality of life through the identification with the university. Our results implied that university authorities should take into consideration the effect of campus atmosphere on life quality of students.
Collaborative Innovation Performance Within Platform-Based Innovation Ecosystems: Identifying Relational Strategies With fsQCA

Collaborative innovation within platform-based innovation ecosystems (PIEs) relies upon the creation of effective partnerships between platform owners and complementors. Despite this, limited research examines the mechanisms that drive collaborative innovation performance within them. To address this important gap, this study performs a fuzzy set qualitative comparative analysis (fsQCA) on 203 Chinese technological firms with the aim of uncovering the distinct configurations of relational elements that drive collaborative innovation within PIEs. The findings reveal three strategies that are equally effective at delivering collaborative innovation: super-modular complementarity in relational operation dependence, unique complementarity in relational operation dependence, and coherence in relational norms dependence. Theoretically, the study contributes to the literature on interorganizational relationships in PIEs and collaborative innovation, by delineating essential relational structures and linking these relational elements to collaborative innovation performance. From a practical standpoint, both platform owners and complementors can use these findings to strengthen their collaborative innovation performance within PIEs.
Cyclic sprinkler irrigation and pre-irrigation substrate water content affect water and N leaching from containers

Abstract A series of sprinkler irrigation experiments were conducted to determine the influences of water application rate (WAR), pre-irrigation substrate water content (PSWC), and cyclic irrigation on water and N leaching from container-grown plants. Prior to experiments, Marigold (Tagetes erecta L. ‘Apollo’), were glass house-grown in pine bark-filled 3.8 liter (1 gal) containers. Prior to treatment, substrate was dried via evapotranspiration (ET) to targeted PSWCs. A simulated overhead irrigation system applied the daily water allotment in a single continuous application or cyclically (multiple applications); in most cases the respective ET volumes were applied to the substrate. Water application efficiency (WAE; water vol retained in substrate + water vol applied to substrate) was determined, and in some experiments, leachates were analyzed for EC, NO3-N and NH4-N. A negative linear relationship existed between WAR and WAE. Leachate NO3-N and NH4-N concentrations were unaffected by WAR, however, total.
Risk-based assessment of wood residential construction subjected to hurricane events considering indirect and environmental loss

Abstract Wood residential construction is susceptible to natural hazards such as hurricanes, which was evident in recent hurricanes such as Hurricane Sandy. Traditional loss analysis typically considers direct loss and thus does not provide a comprehensive estimation of total loss that also includes indirect and environmental losses. This paper proposes a framework to evaluate direct, indirect, and environmental losses of wood residential construction subjected to hurricane events considering a changing climate. The framework contains hurricane simulations including stationary and non-stationary scenarios, time-dependent fragility for key components of building envelop, and loss analysis including direct, indirect, and environmental losses of wood residential construction subjected to hurricane events. It is found that the potential effects of climate change may have a significant impact on the structural vulnerability; indirect and environmental losses account for approximately half of the total losses. The proposed framework can be used for decision-makers and designers to achieve the goal of more resilient and environmentally sustainable structures.
Impersonal constructions in Jóola-Banjal

Joola-Banjal (an Atlantic language spoken in Senegal) has several constructions, not mentioned in previous works on Joola languages, which include no canonical subject. This paper puts forward a formal classification of these constructions and a description of their functions, emphasizing the contribution of this West African language to the general typology of impersonality. Most of the types of impersonal constructions found in Joola-Banjal have already been identified in other languages, but there also several points on which Joola-Banjal shows interesting particularities. Keywords: impersonal constructions; Atlantic languages; Joola
Financial Ratios and Stock Return in the Food and Beverage Company

This study uses financial ratio analysis to investigate the company's stock returns. This study aims to determine the dominant influence of several financial ratios on stock returns. Financial ratios are helpful in evaluating relied returns. The quantitative research approach is used to analyze how financial ratios affect stock returns. The population of this study is companies in the food and beverage sector listed on the Indonesia Stock Exchange. The analysis was carried out from 2017 to 2020 using secondary data sources. Purposive sampling is used in this study, with the sample chosen based on predetermined standards and subjected to multiple linear regression analysis. The analysis' findings demonstrate that DER and TATO have no significant effect on stock returns, while CR, ROA, and ROE have a significant effect on stock returns. optimal corporate profitability is not always achieved by having too many current assets. Additionally, unproductive management of surplus and unused funds will impact declining stock returns. The results of this study indicate that idle current assets cannot generate company profitability because the current ratio is too high indicating an excess of current assets relative to fixed assets.
DPP4 Regulates the Th17/IL-17 Axis and Accelerates Epithelial Mesenchymal Transition to Promote Ovalbumin-Induced Asthma in Female C57BL/6J Mice.

BACKGROUND Dipeptidyl peptidase-4 (DPP4) is a transmembrane glycoprotein, prevalent across a variety of tissues and cells and can be foundin a solubilised in peripheral blood. This paper aims at determining the role of sCD26/sDPP4 in Th17 cell polarization and airway epithelial cell to epithelial mesenchymal transition (EMT) in asthma. METHODS Female C57BL/6J mice were treated with ovalbumin to constructed asthma mice. The CD4+ T cell, and bronchial epithelial cells (BECs) were purified from the spleens and bronchus of mice. The KRT8 expression in BECs were identified by immunofluorescence (IF). Th17 cells were differentiated from a CD4+ T cell. Flow cytometry was usewd to identify and calculate the Th17 and Treg cells. Mice woth asthma were treated by DPP4 overexpressing lentivirus or DPP4 inhibitor. Histopathological modifications were assessed by hematoxylin-eosin (HE), periodic acid Schiff (PAS), and Masson staining. The total number of leucocytes was detected using a hemocytometer. For detection, quantitative Real-time PCR (qRT-PCR), western blotting (WB), and IF were used to evaluate the expression of E-cadherin and alpha-smooth muscle actin (α-SMA). Enzyme-linked immunosorbent assay (ELISA) was performed to analyze the DPP4, IL-4, IL-5, IL-13 and IL-17 levels. RESULTS The findings suggest that sCD26/sDPP4 promote CD4+ T cells differentiation into Th17 cells in a depending on the applied dose. sCD26/sDPP4 up-regulated the expression of α-SMA and down-regulated the expression of E-cadherin in TGF-β1-induced mouse BECs, which was reversed by DPP4 inhibitor. Co-culture induced a synergic effect between Th17 cells and sCD26/sDPP4 on the formation of airway EMT in BECs. Furthermore, DPP4 inhibitor prevented lung-bronchial inflammatory infiltration, mucus secretion, goblet cell hyperplasia and collagen deposition in asthma mice. Meanwhile, DPP4 inhibitor decreased the levels of DPP4, IL-4, IL-5, IL-13, IL-17 and increased the total number of leukocytes in bronchoalveolar lavage fluid of asthma mice. In addition, DPP4 inhibitor also inhibited airway EMT and Th17 cell polarization in asthma mice. CONCLUSIONS The results in this paper show that up-regulation of DPP4 enabled airway inflammation and airway remodeling in asthmatic mice by modulating the Th17/IL-17 axis and accelerating the airway EMT, which isa therapeutic target in asthma.
STELO: A New Modular Robotic Gait Device for Acquired Brain Injury—Exploring Its Usability

In recent years, the prevalence of acquired brain injury (ABI) has been on the rise, leading to impaired gait functionality in affected individuals. Traditional gait exoskeletons are typically rigid and bilateral and lack adaptability. To address this, the STELO, a pioneering modular gait-assistive device, was developed. This device can be externally configured with joint modules to cater to the diverse impairments of each patient, aiming to enhance adaptability and efficiency. This study aims to assess the safety and usability of the initial functional modular prototype, STELO, in a sample of 14 ABI-diagnosed participants. Adverse events, device adjustment assistance and time, and gait performance were evaluated during three sessions of device use. The results revealed that STELO was safe, with no serious adverse events reported. The need for assistance and time required for device adjustment decreased progressively over the sessions. Although there was no significant improvement in walking speed observed after three sessions of using STELO, participants and therapists reported satisfactory levels of comfort and usability in questionnaires. Overall, this study demonstrates that the STELO modular device offers a safe and adaptable solution for individuals with ABI, with positive user and therapist feedback.
Estimating Heterogeneous Preferences to Avoid Flood Risk and the Implications for Disaster Exposure

Flooding remains one of the costliest natural disasters in the United States yet underlying flood risk varies greatly across space. Key policy questions arise regarding potential heterogeneity in Marginal Willingness to Pay (MWTP) to avoid flood risk. In this paper, we estimate household preferences to avoid flood risk in the presence of heterogeneous sorting using house sales across Florida from 1998 to 2012. We begin by using variation across flood risk zones, delineated by the National Flood Insurance Program, to estimate MWTP from a hedonic property value model that identifies preferences to avoid such risks using a boundary discontinuity design (BDD). We examine whether sorting induces correlations between neighborhood flood risk and individual sociodemographics. We then use a discrete choice, residential sorting model that embeds the BDD to estimate heterogeneous preferences for neighborhood attributes (e.g. flood risk). Understanding heterogeneity in preferences for such risks is key to assessing the extent to which vulnerable sub-populations systematically sort into higher risk areas. In addition to providing new valuation estimates for flood risk, our results have implications for the distributional impacts of US natural hazards policies and its potential role in exacerbating inequitable flood risk exposure in the US.