Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Physical Activity among Undergraduate Students in a Local University using a Pedometer

The objective of this study was to assess the pedometer-determined physical activity among a sample of undergraduate students. To obtain the data required, the subjects' total number of steps was assessed using pedometer readings over the course of three days. Measurements of subjects' height, weight, waist and hip circumferences, and blood pressure were also recorded. A total of 174 young adults were involved in this study. The mean age was 20.7 ± 1.3 years; 40.2% were male, and 59.8% were female. The mean body mass index (BMI) was 22.0 ± 4.0 kg/m 2 and the prevalence of overweight and obesity was 10.4% and 3.4%, respectively. Mean steps taken per day were 7587 ± 2704 for females and 8481 ± 2914 for males. Based on waist-hip ratio data, female subjects were classified as having higher risk of chronic disease than males (5.7% vs. 1.2%). Classification of the waist circumference showed similar results (10.9% vs. 6.3%). We found that the number of steps taken per day was not significantly related (p> 0.05) to variables such as waist circumference, hip circumference, waist-hip ratio, BMI and systolic or diastolic blood pressure. Further analysis showed that subjects with fewer than 6594 steps per day (< 33rd percentile) had a higher systolic blood pressure than those subjects who walked more steps in a day (111 ± 14 mmHg vs.106 ±11 mmHg; t=-2.42, p<0.05). Other variables, such as BMI, waist and hip circumferences, waist-hip ratio and diastolic blood pressure were not significantly different among groups with different mean steps per day. The prevalence of a sedentary lifestyle, assessed by the total number of steps taken per day, was less than 15% among the sample of young adults in this study. Further investigation is required to confirm the association between daily step count and blood pressure among young adults.
Effects of kinesiology taping on delayed onset muscle soreness: a randomized controlled pilot study

Purpose: The aim of this study was to determine the effects of kinesiology taping on delayed onset muscle soreness. Methods: Twenty non-athletic volunteers were assigned randomly in two groups, kinesiology taping (N=10) and placebo kinesiology taping (N=10). Participants performed 100 consecutive drop-jumps from a platform 0.60 m in height to induce muscle damage. Kinesiology tape was applied with fan technique on quadriceps femoris muscle in kinesiology taping group while the tape was applied without any technique and no tension in placebo kinesiology taping group. Muscle tenderness was measured using digital algometry at musculotendinous junction and mid-belly of quadriceps femoris muscle. Performance was determined using one leg hop test. Blood samples were obtained for the analysis of serum creatine kinase and myoglobin levels. All measurements recorded before, immediately after, 48 hours, and 72 hours after exercise. Results: Changes in mid-belly of quadriceps femoris muscle tenderness was determined higher in the placebo kinesiology taping group than kinesiology taping group between 48 h after-immediately after exercise (p 0.05). Conclusion: Although kinesiology taping reduces mid-belly of quadriceps femoris muscle tenderness after exercise that induced
Work-Related Musculoskeletal Disorders among Nursing Students during Clinical Training

Background: The Musculoskeletal Disorders (MSDs) have a considerable socio economic impact. First, they drive up costs for workers, companies, and society in general. This applies to both direct and indirect costs associated with occupational diseases and industrial accidents. Nursing students experienced the MSD with increased cases amongst nursing staff. Nursing students continue to face the problems of MSD due to the misuse of the good technique to protect them self during clinical training hours. The study aimed to assess work-related musculoskeletal disorders among nursing students during clinical training. A cross- sectional study design used to achieve this aim. Convenience sampling technique was used to include all consenting nursing students from fifth level to eighth level (3rd and 4th year) (n=253) student who were having clinical training. The study took place at the Faculty of Nursing, Princess Nourah Bint Abdulrahman University. The first part include demographic data questions. The second part is a self-reported pain using standardized Nordic questionnaire for the analysis of musculoskeletal symptoms that will assess different body parts namely upper limb, lower limb, and trunk sections of the body. The study illustrated that more than half of students reported pain (71.1%) and ankle or feet (43.9%) during the last 12 months. Consistent also with students who reported MSD in the last seven days, 48.2% of them reported lower back problem. There is significant relationship between number of clinical days (p = 0.05) and MSD, and no significant relationship between the MSDs and the number of the clinical hours per day (p =0.973), weight (p = 0.806). The main conclusion drawn from the current study is that the majority of nursing students are high risk for MSDs due to improper body mechanics or wrong posture.
MicroRNA-33a-5p overexpression sensitizes triple-negative breast cancer to doxorubicin by inhibiting eIF5A2 and epithelial-mesenchymal transition

Drug resistance is a significant obstacle when treating triple-negative breast cancer (TNBC). Several studies have demonstrated that microRNAs (miRNAs) have essential roles in regulating drug resistance in different types of cancer. miR-33a-5p has previously been reported to be a tumor suppressor in several types of cancer. However, its role in breast cancer remains unknown. The present study aimed to investigate the role of miR-33a-5p in the chemoresistance of TNBC and uncover its potential molecular mechanisms. Cell Counting Kit-8 assay was used to examine cell proliferation, reverse transcription-quantitative PCR analysis was used to examine miR-33a levels, and western blotting and immunofluorescence assays were used to examine the expression of epithelial-mesenchymal transition (EMT)-associated proteins and of eukaryotic translation initiation factor 5A2 (eIF5A2). The results indicated that miR-33a-5p expression was lower in TNBC cells compared with non-TNBC cells. miR-33a-5p overexpression significantly improved the doxorubicin (Dox) sensitivity of TNBC cells, but not that of non-TNBC cells. It was then observed that Dox treatment inhibited miR-33a-5p expression and induced EMT in TNBC cells, by increasing the expression levels of vimentin, while decreasing the expression levels of E-cadherin. Furthermore, it was revealed that forced expression of miR-33a-5p attenuated Dox-induced EMT. eIF5A2 was identified as a potential target of miR-33a-5p, and miR-33a-5p overexpression inhibited the expression of eIF5A2. eIF5A2 inhibition, via its inhibitor GC7, sensitized TNBC cells to Dox and reversed Dox-induced EMT. Overall, the present study demonstrated that miR-33a-5p enhanced the sensitivity of TNBC cells to Dox, by suppressing eIF5A2 expression and reversing Dox-induced EMT, providing a potential therapeutic target for treating drug-resistant TNBC.
Dietary choline intake and biomarkers of choline status across the life cycle

ii Lay summary . iii Preface. iv Table of contents . vi List of tables . xii List of figures . xiv List of abbreviations . xv Acknowledgements . xvii Dedication . xix Chapter 1: Introduction, literature review, and objectives and hypotheses . 1 1.
Salivary Flow in Pediatric Cancer Patients Compared to Healthy Children and Adolescents

Objective: To verify differences between salivary flow in pediatric cancer patients before starting antineoplastic treatment and in healthy pediatric patients. Material and Methods: This is an observational, cross-sectional, paired study with sample of 120 children and adolescents (3-18 years). Thirty pediatric cancer patients were selected for convenience at “Napoleao Laureano” Hospital (G1). Another group was composed of 90 individuals attended at the School of Dentistry Clinics of the Federal University of Paraiba, matched by age (G2). Data collection was performed in two steps for both groups. Information regarding pediatric cancer patients was obtained by interview with parents / guardians and searching medical records, while in the other group by interview with parents / guardians. Saliva collection was performed using standard method in both groups: unstimulated salivary flow rate (USFR) being the mean volume expelled in 1 minute. Data were analyzed by the Shapiro-Wilk, Kolmogorov-Smirnov and Mann-Whitney tests ( α = 5%). Results: Mean USFR for G1 and G2 was 0.52 mL / min and 0.66 mL / min, respectively (p>0.05) and, in both groups, significant difference was observed (p <0.05) between the mean USFR values of its subgroups, and values of adolescents being higher than those of children. Conclusion: There is no difference in unstimulated salivary flow of pediatric cancer patients before starting antineoplastic treatment compared with healthy pediatric patients.
Cancellation-Free Symbolic Analysis of Switched-Capacitor Circuits

In this paper, the cancellation-free technique for transfer function calculation of switched-capacitor (SC) circuits is presented. The proposed analysis technique is based on Generalized Parameter Extraction Method (GPEM). It is shown that network function of SC circuit consists of equal summands with opposite signs. The cancellation terms correspond to determinants of the circuit with singular network elements - norator or nullator. In contrast to matrix-based approaches, the proposed technique provides the direct calculation of cancellation-free network function without symbolic expression simplification. The illustrative example of analysis of the Fleischer-Laker biquad circuit is given.
192Effect of dapagliflozin on cardiovascular outcomes in patients with type 2 diabetes according to baseline renal function and albuminuria status: Insights from DECLARE-TIMI 58

Renal dysfunction including both reduced estimated glomerular filtration rate (eGFR) and the presence of albuminuria have each been shown to predict cardiovascular (CV) outcomes. Sodium glucose co-transporter 2 inhibitors (SGLT2i), which promote glucose excretion in the kidneys, reduce CV events and hospitalizations for heart failure (HHF) in patients with type 2 diabetes mellitus (T2DM). To analyze the CV efficacy of dapagliflozin according to baseline renal function and albuminuria status in DECLARE-TIMI 58. The DECLARE-TIMI 58 trial compared dapagliflozin vs. placebo in 17,160 patients with T2DM and a creatinine clearance >60 ml/min/1.73m2 at enrollment. The dual primary endpoints were CV death/HHF and MACE (MI, stroke, CV death). We categorized patients according baseline eGFR [<60 vs. ≥60 ml/min/1.73m2 according to the CKD-EPI formula] and urinary albumin:creatinine ratio (UACR) [<30 vs. ≥30 mg/g]. Cox regression models with interaction testing were applied. The Gail-Simon test was used to test for interaction of the absolute risk differences. In total, 5198 (30.3%) patients had albuminuria (UACR 30–300: n=4029; UACR >300: n=1169) and 1265 (7.4%) had an eGFR <60 ml/min/1.73m2. Accordingly, 10958 (63.9%) patients had no manifestation of CKD, 5367 (31.3%) had either an eGFR <60 ml/min/1.73m2 or albuminuria, and 548 (3.2%) patients had both manifestations. Patients with more abnormal markers had higher event rates for CV death/HHF (KM event rates at 4 years of 3.9%, 8.3%, 17.4%) and MACE (7.5%, 11.7%, and 18.9%) for no, 1, or 2 markers of CKD, respectively. The relative risk reductions for CV death/HHF and MACE were generally consistent across the subgroups (both P-interaction >0.29), though numerically greatest (42%) in patients with reduced eGFR and albuminuria. However, the absolute risk difference increased substantially in patients with greater kidney damage (absolute risk difference of CV death/HHF: −0.5%, −1.0%, and −8.3%, respectively; P-INT for ARD 0.002; Figure). See figure for MACE and component outcomes. Patients with baseline renal disease had higher rates of adverse CV outcomes. Dapagliflozin reduced events with generally consistent relative risk, but reduced the absolute risk of CVD/HHF by the greatest amount in patients with kidney disease evidenced by both reduced eGFR and albuminuria. AstraZeneca, Deutsche Forschungsgemeinschaft (ZE 1109/1-1)
PREVALENCE OF MALARIA AMONG PREGNANT WOMEN ATTENDING AHMADU BELLO UNIVERSITY MEDICAL CENTER, ZARIA, KADUNA STATE

Malaria is a protozoan disease that poses public health challenges in Nigeria. Inadequate diagnostic test of malaria is responsible for high morbidity and mortality rates in rural areas of Sub-Sahara Africa. This study aimed at the prevalence of malaria among pregnant women attending Ahmadu Bello University Medical Centre (ABUMC), Zaria. A cross-sectional study was conducted among 100 pregnant women attending ABUMC, Zaria. About 2ml of blood was collected through venipuncture into EDTA bottle from the study population from June to August, 2015 and tested for the presence of malaria parasites using microscopy. Prior to sample collection, a structured questionnaire was administered to obtain some socio-demographic and risk factors associated with the disease. A total of 100 pregnant women participated in the study. The overall prevalence of malaria infection among these studied subjects was 60%. Higher prevalence of malaria was recorded among the age group below 15 years (100%), genotype AA (65.7%), those that were unemployed (60.5%), those with secondary education (68.4%) and those in their first trimester of pregnancy (70%). There was no significant difference in prevalence of malaria according to age group (χ 2 = 6.403, p = 0.380). This study reported a high prevalence of malaria among antenatal pregnant women attending ABUMC, Zaria. Effort should be made to provide free bed nets to pregnant women on their first antenatal visit and scale-up intermittent preventive treatment of pregnant women for malaria.
The adhesion molecule ICAM-1 in diffuse large B-cell lymphoma post-rituximab era: relationship with prognostic importance and rituximab resistance

Intercellular adhesion molecule-1 (ICAM-1) is a cell-surface receptor contributing to lymphocyte homing, adhesion and activation. The prognostic significance of the protein is unknown in diffuse large B-cell lymphoma (DLBCL) in post-rituximab era. We detected expression of ICAM-1 immunohistochemically in 102 DLBCL tissue samples. Overexpression of ICAM-1 was found in 28 (27.5%) cases. In patients with low ICAM-1 expression levels, the addition of rituximab to CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy resulted in an improved overall response rate, progression-free survival (PFS) and overall survival (OS) (P=0.019, 0.01, 0.02). In pre-clinical models, we found that chronic exposure of cell lines to rituximab led to downregulation of ICAM-1 and acquirement of a rituximab resistant phenotype. In vitro exposure of rituximab resulted in rapid aggregation of B-cells regardless of the ICAM-1 expression levels. MTT assay showed knockdown of ICAM-1 could cause rituximab resistance. Neutralization of ICAM-1 did not affect rituximab activity in vitro and in vivo. Our data illustrated that in post-rituximab era, R-CHOP significantly improved the ORR, PFS and OS in ICAM-1 negative subset patients. Downregulation of ICAM-1 may contribute to rituximab resistance, and that rituximab, by promoting cell-cell aggregation, may sensitize cells to the cytotoxic effects of chemotherapy agents.
Effets de la consommation de chocolat sur la fonction endothéliale et la tension artérielle des femmes enceintes : une étude pilote

Background: Several randomized clinical trials (RCTs) indicate that flavanol-rich chocolate has beneficial effects on flow-mediated dilation (FMD) and blood pressure (BP). However, no RCTs have evaluated these outcomes in pregnant women. Aims: The objective of this 2-group, parallel, double-blind RCT was to examine the effects of flavanol-rich chocolate on FMD and BP in pregnant women with normal
An Exploration the Risk of Cardiovascular Disease in HIV-Positive Persons in Indonesia using Heart Rate Variability

Cardiovascular disease is the highest cause of death in HIV patients compared to the general population. The number of HIV patients suffering from cardiovascular disease is almost twice as high as patients who are not HIV-positive.The purpose of this study was to identify the risk of cardivascular disease in patients with HIV using ECG short term. This study was used a descriptive comparative to patients with HIV and healthy people as controls in West Java. The inclusion criteria are patients with HIV over the age of 30 years. The exclusion criteria were people with HIV diagnosed with heart disease or being treated for the heart disease. While the inclusion criteria for healthy people as controls are over 30 years of age, do not suffer from cardivascular disease or under treatment of cardiovascular disease. The measurement of heart rate variability is carried out in a supine position in a quiet temperature-controlled room (25-270 C), a 5-minute electrocardiograph (ECG) is recorded using lead II. Differences of heart rate variability indicator were measure using man-whitney test. A total of 20 patients with HIV and 20 healthy people recruited using convinience sampling. The majority of people with HIV were male and aged range between 27 to 51 years old. The results of heart rate variability based on time domain analysis showed that the means normal to normal (NN) was significantly lower in HIV patients compared to controls (978 vs ? vs 902 ms; p<0.05). No differences were found between groups regarding Standard deviation of NN (SDNN), Square root of the mean squared difference of successive NN-intervals (RMSSD) and Percent of differences between adjacent NN intervals greater than 50 ms (pNN50). This study presence of autonomic dysfunction as showed in heart rate variability indicator in a group of HIV compared to the healthy group. Eearly identification of the risk of CVD is important and may inform the implementation of preventive measure by identification of high-risk people who may be candidate for intervention.
Effect of supplementation of Withania somnifera (Ashwagandha) root powder as feed additive on performance and blood biochemicals of broilers

An experiment was conducted on one hundred eighty day old commercial broiler chicks (Ven Cob Strain) to study the effect of Withania somnifera (Ashwagandha) root powder as feed additive on the performance and blood biochemical profile in broilers during 0-6 weeks of age. The chicks were randomly divided into three groups 60 each. All the chicks were housed in deep litter system. The experimental diets were: no feed additive (T0), 0.25 per cent Ashwagandha root powder (T1) and 0.5 per cent Ashwagandha root powder (T2). Body weight gain of T1 (567.00 g) and T2 (581.67 g) was significantly (Ps a herbal feed additive was beneficial in improving average weekly body weight gain, feed conversion ratio and blood biochemical profile.
Combined PIK3CA and FGFR Inhibition With Alpelisib and Infigratinib in Patients With PIK3CA-Mutant Solid Tumors, With or Without FGFR Alterations.

PURPOSE Concurrent PIK3CA mutations and fibroblast growth factor receptor (FGFR) alterations occur in multiple cancer types, including estrogen receptor-positive breast cancer, bladder cancer, and endometrial cancer. In this first-in-human combination trial, we explored safety and preliminary efficacy of combining the PI3Kα selective inhibitor alpelisib with the FGFR1-4 selective inhibitor infigratinib. PATIENTS AND METHODS Patients with PIK3CA-mutant advanced solid tumors, with or without FGFR1-3 alterations, were enrolled in the dose escalation or one of three molecular-defined dose-expansion cohorts. The primary end point was the maximum tolerated dose. Secondary end points included safety, pharmacokinetics, and response. Archival tumor samples were sequenced to explore genomic correlates of response. RESULTS In combination, both agents were escalated to full, single-agent recommended doses (alpelisib, 300 mg per day continuously; infigratinib, 125 mg per day 3 weeks on followed by 1 week off). The toxicity profile of the combination was consistent with the established safety profile of each agent, although 71% of all patients required at least one treatment interruption or dose reduction. Molecularly selected dose expansions in breast cancer and other solid tumors harboring PIK3CA mutations, alone or in combination with FGFR alterations, identified sporadic responses, predominately in tumor types and genotypes previously defined to have sensitivity to these agents. CONCLUSION The combination of alpelisib and infigratinib can be administered at full single-agent doses, although the high rate of dose interruption or reduction suggests long-term tolerability may be challenging. In exploratory signal-seeking cohorts of patients harboring dual PIK3CA and FGFR1-3 alterations, no clear evidence of synergistic activity was observed.
Comparison of clinical outcomes between angiotensin-converting-enzyme inhibitors and ARBs in patients with acute myocardial infarction with dyslipidemia after a successful stent implantation

Objective: Currently, there are limited comparative data concerning long-term major clinical outcomes following the angiotensin-converting-enzyme inhibitors (ACEIs) and angiotensin II type 1 (AT1) receptor blockers (ARBs) therapy in patients with acute myocardial infarction (AMI) with dyslipidemia after a successful stent implantation. Therefore, we investigated major clinical outcomes for 2 years following the ACEIs and ARBs therapy in these patients. Methods: A total of 3015 patients with AMI who underwent a successful stent implantation and were prescribed ACEIs (n=2175) or ARBs (n=840) were enrolled into the study from the Korea AMI Registry (KAMIR). The major clinical endpoint was the occurrence of major adverse cardiac events (MACEs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any repeat-revascularization-comprised target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR. Results: After the adjustment, the cumulative incidence of all-cause death in the ARBs group was significantly higher than in the ACEIs group [adjusted hazard ratio (aHR), 2.277; 95% confidence interval (CI), 1.154–4.495; p=0.018]. The cumulative incidences of MACEs (aHR, 1.305; 95% CI, 0.911–1.869; p=0.146), cardiac death, Re-MI, any repeat revascularization, TLR, TVR, and non-TVR were similar between the two groups. In addition, an advanced age (≥65 years), decreased left ventricular ejection fraction (<50%), and cardiopulmonary resuscitation on admission were meaningful independent predictors for all-cause death in this study. Conclusion: ACEIs were a preferred treatment modality when compared to ARBs for patients with AMI with dyslipidemia who underwent a successful stent implantation to reduce the incidences of all-cause death during a 2-year follow-up. However, additional research is required to determine the clinical implications of these results.