Miracle-dz/UniFAR-FTUs huggingface dataset:
A NOVEL THREE DRUG RIGEMEN (MOXIFLOXACIN –OMEPRAZOLE - NITAZOXANIDE) IN COMPARISON TO TRADITIONAL TRIPLE THERAPY FOR TREATMENT AND ERADICATION OF NAÏVE AND RESISTANT H.PYLORI INFECTION IN DYSPEPTIC PATIENTS

Background: Helicobacter pylori is one of the most common, medically prominent infection worldwide and one of the major causative factor of peptic ulcer disease. So, eradication of H. pylori is effective in healing ulcers, reducing the ulcer recurrence and eliminating the need for maintenance therapy. Objective: The aim of the work was to compare between the efficacy of traditional triple therapy and Moxifloxacin-based triple therapy in treatment of H. pylori infection and to evaluate the efficacy of moxifloxacin-based regimens as a rescue regimen for H. pylori eradication in resistant patients. Patients and methods: This study was carried out on 100 Helicobacter pylori (H. pylori)-infected patients (within the period between septemper, 2018 to May, 2019) who were enrolled from Hepatology, Gastroenterology & Tropical Medicine Department, Al Azhar University Hospitals (El-Hussein and BAB El-Shaarea). Results: Helicobacter pylori eradication results in group III as evaluated by monoclonal H. Pylori stool Ag, 6 weeks post therapeutic regimens reported that eradication rate was 76.9% (20 patients). Regarding post treatment clinical data in group III, 42.3% of patients remained having symptoms and 57.7% had acheived symptomatic improvement. Also, the best results were recorded for H.pylori eradication (90%) in group II who received moxifloxacin based triple therapy compared to group I (with eradication rate 62.9%) who received traditional triple therapy regimen. Thus the better results (76.9%) were achieved in group III (resistant patients from group I). Conclusion: The present results could state that moxifloxacin can overcome traditional triple therapy resistance.
ORIGINAL ARTICLE Anti-Influenza Antibody Level After Vaccination In North Of Iran

Objective:Influenza is a highly transmitted disease and about 10% of the world’s population is affected by this disease annually. The aim of this research was to study the variation of serum antibody levels among subjects who had already been vaccinated against influenza. Methods And Materials:This descriptive-analytical study was carried out on 196 subjects who had influenza vaccination (influvac 2005/2006) and on 200 subjects who were matched with the vaccinated subjects by their ages in Gorgan which is located in the northeast of Iran. The subject's sera were prepared seven weeks after the influenza vaccination. Their serum antibody levels were determinated by the heamaglutination inhibition test. Results:The antibody titre in 81 subjects of the vaccinated group and in 175 subjects of the control group was less then 1/40. The mean antibody titre of the vaccinated subjects and the control group was 143.4±10.89 and 18.34±3.2, respectively. The difference was statistically significant (P value=0.000). Conclusion:The findings showed that the mean titre of the antibodies in the vaccinated and control groups was statistically different. This means that the influenza vaccine has good efficacy in our population.
Anterior segment parameters and tear functions in patients with thalassemia major

Aim: To determine whether the biomicroscopic, topographic and biomechanical properties of the anterior segment and the tear function have changed in Thalassemia Major (TM) patients. Material and Methods: Eighty-eight eyes of patients with TM and 102 eyes of healthy controls paired with age, gender, and spherical equivalent were included in this cross- sectional case-control study. Biomicroscopic, topographic and biomechanical findings of anterior segment and Schirmer test measurements were compared between the two groups. Results: The mean age was found to be 15.11±6.01years in TM group, and 13.83±4.92 years in the control group (p=0.17). In 34 (38.63%) patients with TM, minor peripheral lens opacities were detected. Visual acuity was 20/20 in all patients with lens opacity. The mean iridocorneal angle (ICA) was 44.67±5.86 and the topographic anterior chamber depth (ACD) was 3.65±0.28 mm in the TM patients. Mean ICA was 48.78 ± 6.51 and topographic ACD was 3.76±0.30 mm in the control group (p
CHROMOSOMAL BREAKAGE TEST IN THE DIAGNOSIS OF FANCONI ANEMA IN PATIENTS WITH APLASTIC ANEMIA

Fanconi anemia (FA) is a rare recessive genetic disorder characterized by bone marrow failure, developmental delay, congenital malformations, genomic instability and a high cancer risk. To date 15 different FA genes have been identified. Chromosomal breakage test (CBT) using mitomycin C in peripheral blood lymphocyte culture to diagnose FA is performed as a routine diagnostic test by our Cytogenetic Laboratory. We report here the findings of CBT on the blood samples of 82 patients with aplastic anemia (AA). Three out of 82 AA patients (3.7%) were positive for CBT. The diagnosis of FA was made only when CBT was positive, and the results consistent with clinical and hematological data. About 96.3% of the AA patients were negative for CBT. Genetic reversion in FA may result in ‘spontaneous’ hematologic improvement and lymphocyte mosaicism, thus giving a false negative result for CBT. In patients who were negative for chromosomal breakage blood test and if FA is highly suspected, then the next tier of tests should be considered. FA testing could be performed on skin fibroblasts to overcome misleading results in blood lymphocytes. © 2013 Universal Research Publications. All rights reserved
Forensic dentistry and disaster victim identification (DVI) in Indonesia

ABSTRACT The forensic dentist plays an important role in the disaster victim identification (DVI) operations. The first aim of this study was to explore the opinions of Indonesian dentists on the importance of dental records and the respective awareness of Forensic Dentistry. The second aim was to investigate the basic profile of the Indonesian dentists and their experiences working in the DVI operations. Two web-based surveys (S1 and S2) were sent to 360 Indonesian dentists and eight Indonesia DVI team members, respectively. Results for S1 showed that most dentists (305 out of 341) are aware of the field and the importance of dental records in human identification; however, only 26% of dentists always compile a complete dental chart of the patient. DVI team members (6 out of 8) have an academic background in the field and only the minority experienced difficulties in deployments. Indonesia is susceptible to natural disasters and dentists proved to be important in DVI. Although the Ministry of Health of Indonesia has provided guidelines, the recording of dental data is not up to standard. A regular and systematic monitoring by the dental councils to every dental clinic would certify if dentists are compiling and keeping accurate dental records.
Foodborne Illness in Taiwan, 1981-1989

During 1981 to 1989, 622 outbreaks of foodborne illness (15,627 cases) were reported in Taiwan, with more outbreaks in summer than other times of the year. Outbreaks were mainly caused by mishandling of food in the home and in the food service industry. Seafood products were the major sources; only a few outbreaks were attributed to dairy products. Pathogens accounted for 80% of the confirmed incidents. Chemical agents and natural toxins appeared to be minor causes. The most frequently identified bacterial isolate was Vibrio parahaemolyticus, followed by Staphylococcus aureus and enteropathogenic E. coli.
PRACTICES AND ATTITUDE OF GENERAL DENTISTS IN SAUDI ARABIA TOWARDS VARIOUS CARIES PREVENTION METHODS

The objective of the study was to determine the practices and attitude of general dentists in Saudi Arabia towards various caries preventive methods. A self-administered questionnaire was utilized to obtain the required information. The study sample consisted of general dentists attending the annual meeting of Saudi Dental Society in Riyadh. Results showed that nine in ten (91.2%) dentists provide oral hygiene instructions to their patients. Majority (78.1%) of the dentists provide the oral hygiene instructions at the first and last dental visit. More than four-fifth (83.3%) of the dentists provide dietary advice to their parents and the majority (78.1%) provide it only at the first dental visit. Four-fifth (80.7%) of the dentists performs dental prophylaxis on their patients. A considerable number (41.2%) of dentists do not use professional topical fluoride, and 72.8% do not prescribe fluoride supplements. The oral hygiene advice is rated as the most important preventive method for dental caries prevention by 87.7% of the dentists. Slightly more than half (53.5%) of the dentists have attended a continuing dental education program in preventive dentistry, but only 30.7% have attended any such program in preventive dentistry within the past two years. In conclusion, the general dentists attitude towards preventive is generally positive and their practices are mostly prudent. However, they need to improve in the area of reinforcement and follow-up of preventive advice.
Neonatal Subgaleal Hemorrhage in a Multihospital Healthcare System: Prevalence, Associations, and Outcomes

Objective: Neonatal subgaleal hemorrhage is more common after operative delivery (vacuum or forceps) than after non-instrumented delivery, but can occur when neither vacuum nor forceps were used. We sought to describe recent vacuum and forceps usage in a multihospital system and to identify all cases of subgaleal hemorrhage and to associate these with delivery type. Methods: Using data repositories of Intermountain Healthcare we tabulated vacuum and forceps use during the past 8½ years, seeking trends over time and as a function of the size of the delivery service. Records were reviewed of all neonates where subgaleal hemorrhage was recognized, seeking associations with delivery practices, and describing the outcomes. Results: Vacuum-assisted deliveries constituted a higher proportion of deliveries in hospitals with fewer than 1000 births per year, but forceps use was not associated with delivery service size. Vacuum assistance occurred in 4.8% of all deliveries in the system, with no yearly change in usage, but forceps use diminished from 5.3% of deliveries in 2002 to 4.7% in 2003 and to 2.4% thereafter. During this period 38 neonates were recognized to have a subgaleal hemorrhage. Twenty-one occurred after vacuum, two after forceps, four after vacuum followed by forceps, and 11 when neither vacuum nor forceps were used. Thirty-five were admitted to an intensive care unit. Transfusions were given to 13, but no transfusions were given in the group where neither vacuum nor forceps was used, suggesting their hemorrhages were less severe. Adverse outcomes of subgaleal hemorrhage included death in two, persistent seizures in one, and neurodevelopmental delay in another. All others where follow-up data were available (n=23) were normal. In this health system the prevalence of recognized subgaleal hemorrhage is one case per 7123 deliveries, one per 598 vacuum-assisted deliveries, and one per 1059 forceps-assisted deliveries. Conclusion: In our system, severe subgaleal hemorrhage is invariably associated with the use of vacuum or forceps. It is uncertain whether the poor outcome seen in 10% of our neonates with subgaleal hemorrhage is due to the hemorrhage itself, or is the consequence of events preceding or unrelated to the bleeding. We suggest that is it a wise practice, when vacuum or forceps are used, to convey this information to the pediatrician. We also suggest that the topic of subgaleal hemorrhage be periodically reviewed, as continuing education for all involved in neonatal care.
Understanding and Healing Historical Trauma: The Perspectives of Native American Elders

In this phenomenological study 11 Native American elders addressed three research questions: (a) the effect of historical trauma on self, family, and community; (b) how historical trauma currently affects Native people and their communities; and (c) what they would recommend that counselors and therapists do in addressing issues of historical trauma for Native and tribal people. All participants spoke of historical trauma in terms of loss of tribal language and culture. They seemed to speak directly to Native people themselves as having the answers to healing and wellness for their own people; however, recommendations for nontribal people who work with Native people and communities were discussed.
Recombinant Human Butyrylcholinesterase as a Therapeutic Agent to Counteract the Effects of VX Toxicity in Domestic Swine

The efficacy of a recombinant human butyrylcholinesterase (rBChE) in protecting against topically administered VX was examined in anaesthetized domestic swine. Animals exposed to 2LD50 of VX showed signs of organophosphate poisoning and died within 2—3 hours. When a single dose of rBChE was administered 15 min post VX exposure, survival times increased but the animals died before the end of the six-hour test period. In an attempt to increase the effectiveness of rBChE, the dose was administered in 5 equal portions at various times post-agent. The animals survived with little or no signs of poisoning. Using this multiple rBChE dosing regimen, animals were monitored for 7 days following VX exposure. The VX exposed and rBChE treated animals were compared to swine that received rBChE only or were exposed to VX and treated with the current standard of treatment for nerve agent poisoning: 2PAM and atropine. Animals were monitored for clinical signs, body weight and cognitive function. Blood samples were taken to determine biochemistry, electrolytes and cholinesterase levels. None of the surviving animals displayed any sign of cognitive impairment, moreover no hematological or chemical abnormalities were observed. These results demonstrated that rBChE was effective in protecting the animals against a lethal dose of VX.
Intraoperative cell salvage use reduces the rate of perioperative allogenic blood transfusion in patients undergoing periacetabular osteotomy

Abstract Blood loss during periacetabular osteotomy (PAO) is variable, with losses ranging from 100 to 3900 ml in published series. Perioperative allogenic blood transfusion is frequently utilized although is associated with significant risk of morbidity. Cell salvage (CS) is a common blood conservation tool; however, evidence supporting its use with PAO is lacking. Our aim was to assess whether CS affects perioperative allogenic blood transfusion rate in patients undergoing PAO. The clinical records of 58 consecutive PAOs in 54 patients (median age 24.7 years, interquartile range 17.8–29.4 years) performed by a single surgeon between 1 January 2016 and 30 April 2018 were reviewed. Autologous blood pre-donation and surgical drains were not used. Due to variable technician availability, CS was intermittently used during the study period. PAOs were allocated into a CS group or no cell salvage group (NCS group), according to whether an intraoperative CS system was used. There was no significant difference in patient age, gender, body mass index, dysplasia severity, regional anesthetic technique, tranexamic acid administration, surgical duration or estimated blood loss (all P > 0.05) between the two groups. The CS group had a lower preoperative hemoglobin compared to the NCS group (median, 13.4 g/dl versus 14.4 g/dl, P = 0.006). The incidence of allogenic blood transfusion was significantly lower in the CS group compared to the NCS group (2.5% versus 33.3% patients transfused, P = 0.003). Multivariate modeling showed CS use to be protective against allogenic blood transfusion (P = 0.003), with an associated 80-fold reduction in the odds of transfusion (odds ratio, 0.01; 95th% CI, 0–0.57). To our knowledge, this is the first study to assess the effect of CS use on allogenic transfusion rate in patients undergoing PAO. Our results demonstrate CS to be a mandatory component of blood conservation for all patients undergoing PAO.
Prevalence of depression and its relationship with sociodemographic characteristics among women in a rural town of western Turkey

Objective: The aim of this study was to investigate the prevalence of depression and evaluate some risk factors associated with depression in a rural town. Methods: In this survey conducted between July 1(st) and August 30(th) 2007, a questionnaire including the information related some sociodemographic characteristics and some risk factors assumed as related with depression was completed using a face to face interview method. The Beck Depression Scale was used as the screening test. Data were evaluated by desciptive statistics, logistic regression analysis, chi-square and student t tests. Results: The mean age of the respondents was 56.03 years. The prevalence of depression in this sample was 16.6% (115/691). The bivariate analyses revealed that, in those with an advanced age, any chronic illness, an event history affecting the life in a negative way, a handicapped child, menopause, obesity, and not having a social health insurance, the depression prevalence were significantly higher in multivariate analysis, not having a social health insurance (OR: 2.52), an event history affecting the life in a negative way (OR: 2.99), a handicapped child (OR: 3.37) and an age group of 30-39 as menopause age (OR: 2.75) were all deemed significant as risk factors for depression. Discussion: Depression is an important health problem for women dwelling in this region. We concluded that women should be evaluated as an important at-risk group for depression, and prevention and control programs that also include components for reducing stigma should be implemented.
Recurrent Thymoma-Associated Paraneoplastic Encephalitis Resulting From Multiple Antibodies: A Case Report

Few reports describe the clinical course and acute-care management of patients with recurrent multi-antibody paraneoplastic encephalitis. We describe a rare case of a patient having thymoma with multiple paraneoplastic syndromes who was found to have antibodies to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) followed by N-methyl-d-aspartate (NMDA) receptor in the setting of residual thymic tissue. He initially presented to the hospital with severe, rapidly progressive encephalitis with simultaneous antibodies to AMPA and voltage-gated potassium channel complex receptor. Brain magnetic resonance imaging revealed scattered white matter hyperintensities and an enhancing lesion adjacent to the left caudate. Computerized tomography showed an anterior mediastinal mass that was resected and revealed to be a thymoma. He was refractory to treatment with intravenous immunoglobulin, high-dose steroids, and plasmapheresis. He was then started on monthly cyclophosphamide. After 3 cyclophosphamide infusions, he began to show improvement in his alertness, ability to speak, and capacity to follow commands. One month later, he was readmitted to the hospital for new and unusual behavioral outbursts and agitation. He was found to have new anti-NMDA receptor antibodies in his cerebrospinal fluid in the setting of residual hyperplastic thymic tissue that required another resection. He was treated with rituximab and then cyclophosphamide (due to an infusion reaction with rituximab) with positive outcomes. The presence of multiple antibodies may be associated with poor prognosis, requiring prompt recognition and aggressive immunosuppressive treatment. New neurological symptoms should prompt a search for residual pathologic tissue or tumor recurrence causing new autoantibodies and additional paraneoplastic syndromes.
Bacteriological Profile and Antibiogram Pattern in Lower Respiratory Tract Infection in Kota Region (Raj)

Lower respiratory tract infections are the most frequent infections among patients. The consequences on increased drug resistance are far reaching, since bacterial infection of the lower respiratory tract is a major cause of death from infections disease. This study was focused on obtaining a comprehensive insight into the microbial profile, its prevalence and the antibiotic susceptibility patterns of the isolates in lower respiratory tract infections. Sputum specimens were collected from 1800 patients of all the age and sex groups with symptoms of LRTIs. Following culture, the isolated organisms were identified and antimicrobial sensitivity was performed by standard methods. Out of the 1800 sputum culture samples, significant pathogens were isolated in 546 sputum samples. Male (n=380) were found to be more at risk to LRTIs then females (n=166). LRTIs were found more prevalent in 60 years or older age groups. K. pneumoniae (25.30%) was the commonest pathogen isolated, followed by Pseudomonas aeroginosa (21.80%), Staphylococcus aureus (20.14%), Streptococcus pyogenes (9.90%), E. coli (8.24%), Candida albicans (7.90%), Acinetobacter species (4.39%), Citrobacter species (1.46%), Enterobacter species (0.54%) and Proteus species (0.33%). Gram positive organisms showed 90–100% susceptibility to Vancomycin, Levofloxacin, Amikacin and Linezolid; while majority of gram negative organisms had high susceptibility to piperacillin tazobactam, imipenam, cefoperazone/sulbactum, amikacin, and ceftazidimie/tazobactam. The emergence of resistant strains poses a major threat to the patients, globally. The reason for the resistance may be due to indiscriminate use and abuse of drugs, adulteration of drugs and mutation of microorganisms. Before starting empirical antibiotics on patients with moderate to severe lower respiratory tract infections, it is always advisable to obtain sputum for culture and antibiotic sensitivity test. So, inappropriate and irrational drug usage can be avoided. Keywords: Lower respiratory tract infection, sputum sample Cite this Article Dinesh Verma, Pappu Kumar, Naveen Saxena, et al. Bacteriological Profile and Antibiogram Pattern in Lower Respiratory Tract Infection in Kota Region (Raj). Research & Reviews: Journal of Microbiology and Virology . 2016; 6(2): 13–17p.
Fraturas da extremidade distal do rádio tratadas pela técnica de Ulson

O método de Ulson, fixação interna e externa combinada, usado no tratamento das fraturas da extremidade distal do rádio, foi realizado em 146 pacientes, totalizando 148 punhos, no período de março de 1999 a maio de 2001, de acordo com as indicações e com base nas classificações de fraturas usadas no serviço. O objetivo deste trabalho é analisar a técnica de Ulson de acordo com classificações citadas na literatura. A média do seguimento foi de 10 meses, com variação de três a 20 meses. A média de idade dos pacientes era de 53 anos. O principal mecanismo de lesão foi a queda ao solo, com 132 casos. Houve 22 complicações: quatro casos de distrofia simpático-reflexa, quatro de encurtamento de rádio, três de instabilidade radioulnar distal, quatro de infecção, três de diminuição da força de preensão e quatro de diminuição do grau de mobilidade. A avaliação objetiva dos pacientes foi baseada nos critérios funcionais modificados de Green e O’Brien (1978) e, subjetivamente, por um questionário relacionado às atividades diárias dos pacientes, perfazendo um total de 64 (43,2%) resultados considerados como excelentes, 62 (41,9%) bons, 18 (12,2%) regulares e quatro (2,7%) poABSTRACT