Miracle-dz/UniFAR-FTUs huggingface dataset:
Product quality in different strains of tench (Tinca tinca) tested under controlled environmental conditions

Summary Tench is produced in pond aquaculture in Europe and is highly valued by consumers. However, little is known about the product quality of this species, including body composition and flesh quality which are relevant for processing, storage and marketing. The experimental investigations indicate that tench are favorable in several parameters of body composition, e.g. carcass yield and fillet percentage, when compared with common carp. Organ weights show a trend toward a lower percentage than in other cyprinids. Composition of the tench fillets is similar to that of common carp. However, tench are able to store large amounts of fat on the fillet surface and intramuscularly, significantly affecting the sensorial characteristics. Technological parameters indicate that tench fillet is quite favorable for processing. In most of the samples analyzed, the water-binding capacity of raw muscle was significantly better than in other species. Owing to a high energy content in tench muscle, the post-mortem decrease in pH is very pronounced, which may lead to a rapid autolytic degradation of the tissue. When compared with common carp, tench fillets were favorable in terms of appearance due to a lighter flesh. Large variations in several product quality parameters reflect differences in fish size, age, sex, feeding, and genetic origin.
Late seizures in cerebral venous thrombosis

Objective To examine the incidence, characteristics, treatment, and predictors of late seizures (LS) after cerebral venous thrombosis (CVT), we described these features in a registry of 1,127 patients with CVT. Methods We included consecutive adult patients from an international consortium of 12 hospital-based CVT registries. We excluded patients with a history of epilepsy or with <8 days of follow-up. We defined LS as seizures occurring >7 days after diagnosis of CVT. We used multivariable Cox regression to identify predictors of LS. Results We included 1,127 patients with CVT. During a median follow-up of 2.0 years (interquartile range [IQR] 1.0–6.3), 123 patients (11%) experienced ≥1 LS (incidence rate for first LS 30 per 1,000 person-years, 95% confidence interval [CI] 25–35). Median time to first LS was 5 months (IQR 1–16 months). Baseline predictors of LS included status epilepticus in the acute phase (hazard ratio [HR] 7.0, 95% CI 3.9–12.6), decompressive hemicraniectomy (HR 4.2, 95% CI 2.4–7.3), acute seizure(s) without status epilepticus (HR 4.1, 95% CI 2.5–6.5), subdural hematoma (HR 2.3, 95% CI 1.1–4.9), and intracerebral hemorrhage (HR 1.9, 95% CI 1.1–3.1). Eighty-five patients (70% of patients with LS) experienced a recurrent seizure during follow-up, despite the fact that 94% received antiepileptic drug treatment after the first LS. Conclusion During a median follow-up of 2 years, ≈1 in 10 patients with CVT had LS. Patients with baseline intracranial bleeding, patients with acute symptomatic seizures, and those who underwent decompressive hemicraniectomy were at increased risk of developing LS. The high recurrence risk of LS justifies epilepsy diagnosis after a first LS.
Hematopoietic Stem Cell Gene Therapy for Inherited Monogenic Diseases and Its Implications for Future Gene Therapy Trials in Turke

Kok hucre tedavisi rejeneratif tip ve restoratif tip alanlarinda yeni tedavilerin gelistirilmesi icin buyuk avantaj saglamaktadir. Boylelikle, kok hucre tedavilerinin kullanimi ve bunlarin klinik endikasyonlari hucrelerin genetik modifikasyonu ile gelistirilebilmektedir. Turkiye’deki akraba evlilik oraninin fazla olmasindan dolayi, yenidogan genetik kalitsal hastaliklarin insidasi artmaktadir ve bu durum bir sorun teskil etmektedir. Bu hastaliklarin tedavi edilmesi; 1) kirsal bolgelerde hastaligin siklikla gec teshisi, 2) Ozel merkezlerin uzak olmasi, 3) Tedavilerin sik hastane kontrolu gerektirmesi, 4) Tedavi prosedurlerinin hem pahali hem de invazif olmasi nedenleriyle zordur. Bu makalede nadir kalitsal monogenik hastaliklar icin hematopoetik kok hucre (HKH) gen tedavisinin guncel durumlari ve Turkiye’deki hastalar icin alternatif bir tedavi secenegi olarak kullaniminin avantajlari tartisilacaktir. Immun yetmezlikler, hemoglobinopatiler, bircok enzim eksikliklerinde retroviral ve lentiviral gen tedavi klinik calisma sonuclari, HKH gen tedavisi alanindaki yeni gelismeler, guvenlik ve etkinligin artirilmasi ve gelecekteki oneriler tartisilacaktir.
Comparative Pathology of Pseudorabies in Different Naturally and Experimentally Infected Species—A Review

The pseudorabies virus (PRV) is an alphaherpesvirus and the causative agent of Aujeszky’s disease (AD). PRV infects a wide range of animal species including swine as the natural host as well as ruminants, carnivores, rodents and lagomorphs. In these species, except for the pig, PRV infection causes acute, severe disease, characterized by insatiable itching, and is always lethal. Horses, chickens and non-human primates have been shown to be largely resistant to PRV infection, while disease in humans is still controversial. PRV is a pantropic virus, which preferably invades neural tissue, but also infects epithelia of various organs, whereupon multisystemic lesions may result. Although AD is mainly associated with severe pruritus, also known as “mad itch”, there are notable differences regarding infection route, clinical signs, viral distribution and lesion patterns in different animal species. In this comprehensive review, we will present clinico-pathologic findings from different species, which have been either shown to be susceptible to PRV infection or have been tested experimentally.
Classifying Breast Cancer Subtypes Using Deep Neural Networks Based on Multi-Omics Data

With the high prevalence of breast cancer, it is urgent to find out the intrinsic difference between various subtypes, so as to infer the underlying mechanisms. Given the available multi-omics data, their proper integration can improve the accuracy of breast cancer subtype recognition. In this study, DeepMO, a model using deep neural networks based on multi-omics data, was employed for classifying breast cancer subtypes. Three types of omics data including mRNA data, DNA methylation data, and copy number variation (CNV) data were collected from The Cancer Genome Atlas (TCGA). After data preprocessing and feature selection, each type of omics data was input into the deep neural network, which consists of an encoding subnetwork and a classification subnetwork. The results of DeepMO based on multi-omics on binary classification are better than other methods in terms of accuracy and area under the curve (AUC). Moreover, compared with other methods using single omics data and multi-omics data, DeepMO also had a higher prediction accuracy on multi-classification. We also validated the effect of feature selection on DeepMO. Finally, we analyzed the enrichment gene ontology (GO) terms and biological pathways of these significant genes, which were discovered during the feature selection process. We believe that the proposed model is useful for multi-omics data analysis.
Deep Learning Aided Grant-Free NOMA Toward Reliable Low-Latency Access in Tactile Internet of Things

Tactile Internet of Things (IoT) requires ultraresponsive and ultrareliable connections for massive IoT devices. As a promising enabler of tactile IoT, grant-free nonorthogonal multiple access (NOMA) exploits the joint benefit of grant-free access and nonorthogonal transmissions to achieve low latency massive access. However, it suffers from the reduced reliability caused by random interference. Hence, we formulate a variational optimization problem to improve the reliability of grant-free NOMA. Due to the intractability of this problem, we resort to deep learning by parameterizing the intractable variational function with a specially designed deep neural network, which incorporates random user activation and symbol spreading. The network is trained according to a novel multiloss function where a confidence penalty based on the user activation probability is considered. The spreading signatures are automatically generated while training, which matches the highly automatic applications in tactile IoT. The significant reliability gain of our scheme is validated by simulations.
Redescription of Placobdella papillifera Verrill, 1872 (Hirudinida: Glossiphoniidae)

ABSTRACT The identification and taxonomy of Placobdella papillifera (Verrill, 1872) Moore, 1952 have been blurred by its varieties and have been compounded by the apparent lack of type material. Leeches collected from May 2008 through August 2012 from West River, New Haven, New Haven County, Connecticut, the type locality of Clepsine papillifera Verrill, 1872, were consistant with P. papillifera (Verrill, 1872) Moore 1952 as described by Verrill (1872). The acquisition of these specimens from the type locality facilitated redescription of P. papillifera. A neotype is designated to stabilize the concept of P. papillifera. Placobdella papillifera appears to exhibit relatively low host specificity, having been documented on Chrysemys picta, Chelydra serpentina, Sternotherus odoratus and Homo sapiens in this study. Molecular comparison of CO-I sequence data from P. papillifera revealed differences of 15% from Placobdella ornata, 16% from P. rugosa, 18% from P. ali, 17% from P. multilineata and 14% from P. parasitica.
Use of Whole Genome Sequencing Data for a First in Silico Specificity Evaluation of the RT-qPCR Assays Used for SARS-CoV-2 Detection

The current COronaVIrus Disease 2019 (COVID-19) pandemic started in December 2019. COVID-19 cases are confirmed by the detection of SARS-CoV-2 RNA in biological samples by RT-qPCR. However, limited numbers of SARS-CoV-2 genomes were available when the first RT-qPCR methods were developed in January 2020 for initial in silico specificity evaluation and to verify whether the targeted loci are highly conserved. Now that more whole genome data have become available, we used the bioinformatics tool SCREENED and a total of 4755 publicly available SARS-CoV-2 genomes, downloaded at two different time points, to evaluate the specificity of 12 RT-qPCR tests (consisting of a total of 30 primers and probe sets) used for SARS-CoV-2 detection and the impact of the virus’ genetic evolution on four of them. The exclusivity of these methods was also assessed using the human reference genome and 2624 closely related other respiratory viral genomes. The specificity of the assays was generally good and stable over time. An exception is the first method developed by the China Center for Disease Control and prevention (CDC), which exhibits three primer mismatches present in 358 SARS-CoV-2 genomes sequenced mainly in Europe from February 2020 onwards. The best results were obtained for the assay of Chan et al. (2020) targeting the gene coding for the spiking protein (S). This demonstrates that our user-friendly strategy can be used for a first in silico specificity evaluation of future RT-qPCR tests, as well as verifying that the former methods are still capable of detecting circulating SARS-CoV-2 variants.
The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis

Preclinical and/or clinical evidence has indicated a potential role of steroid hormone-mediated signaling pathways in the development of various neoplastic diseases, while precise mechanisms for the functions of specific receptors remain poorly understood. Specifically, in urothelial cancer where sex-related differences particularly in its incidence are noted, activation of sex hormone receptors, such as androgen receptor and estrogen receptor-β, has been associated with the induction of tumor development. More recently, glucocorticoid receptor has been implied to function as a suppressor of urothelial tumorigenesis. This article summarizes and discusses available data suggesting that steroid hormone receptors, including androgen receptor, estrogen receptor-α, estrogen receptor-β, glucocorticoid receptor, progesterone receptor and vitamin D receptor, as well as their related signals, contribute to modulating urothelial tumorigenesis.
Differences in Comorbidities Between Children and Youth With Suicide Attempts Versus Ideation Presenting to the Emergency Department

Abstract Objective The aim of this work was to explore identified risk factors for suicidal ideations and attempts and the differences in these risk factors between emergency department encounters among youth seeking medical care for suicide attempt and those with suicidal ideation. Method This was a retrospective analysis of suicide-related claims for emergency department visits from nine state-level Healthcare Cost and Utilization Project databases for youth aged 5 through 19 years. Risk factors were estimated by identifying comorbidities recorded in first five diagnosis codes. Odds ratios comparing rates of these comorbidities in encounters for suicide attempts compared to encounters for suicidal ideation were estimated using multivariate logistic regression. Results In all, 169,047 encounters for suicide-related behavior were identified. We found higher odds of concurrent anxiety, personality disorders, and alcohol-related diagnoses and lower odds of a comorbid psychosis diagnosis, attention deficit hyperactivity disorder, and other substance-related diagnoses in the population of suicide attempters compared to patients with suicidal ideation alone. Conclusion The odds of diagnoses of specific comorbidities differed in youth encounters for suicide attempts compared to encounters for suicidal ideation.
Development and validation of a predictive model of drug-resistant genetic generalized epilepsy

Objective To develop and validate a clinical prediction model for antiepileptic drug (AED)–resistant genetic generalized epilepsy (GGE). Method We performed a case-control study of patients with and without drug-resistant GGE, nested within ongoing longitudinal observational studies of AED response at 2 tertiary epilepsy centers. Using a validation dataset, we tested the predictive performance of 3 candidate models, developed from a training dataset. We then tested the candidate models' predictive ability on an external testing dataset. Results Of 5,189 patients in the ongoing longitudinal study, 121 met criteria for AED-resistant GGE and 468 met criteria for AED-responsive GGE. There were 66 patients with GGE in the external dataset, of whom 17 were cases. Catamenial epilepsy, history of a psychiatric condition, and seizure types were strongly related with drug-resistant GGE case status. Compared to women without catamenial epilepsy, women with catamenial epilepsy had about a fourfold increased risk for AED resistance. The calibration of 3 models, assessing the agreement between observed outcomes and predictions, was adequate. Discriminative ability, as measured with area under the receiver operating characteristic curve (AUC), ranged from 0.58 to 0.65. Conclusion Catamenial epilepsy, history of a psychiatric condition, and the seizure type combination of generalized tonic clonic, myoclonic, and absence seizures are negative prognostic factors of drug-resistant GGE. The AUC of 0.6 is not consistent with truly effective separation of the groups, suggesting other unmeasured variables may need to be considered in future studies to improve predictability.
The phenomenology of auditory verbal hallucinations in emotionally unstable personality disorder and post-traumatic stress disorder

Objective: To explore the phenomenology of auditory verbal hallucinations (AVHs) in a clinical sample of young people who have a ‘non-psychotic’ diagnosis. Methods: Ten participants aged 17–31 years with presentation of emotionally unstable personality disorder or post-traumatic stress disorder and frequent AVHs were recruited and participated in a qualitative study exploring their subjective experience of hearing voices. Photo-elicitation and ethnographic diaries were used to stimulate discussion in an otherwise unstructured walking interview. Results: ‘Non-psychotic’ voices comprised auditory qualities such as volume and clarity. Participants commonly personified their voices, viewing them as distinct characters with which they could interact and form relationships. There appeared to be an intimate and unstable relationship between participant and voice, whereby voices changed according to the participants’ mood, insecurities, distress and circumstance. Equally, participants reacted to provocation by the voice, leading to changes in mood and circumstance through emotional and physical disturbances. In contrast to our previous qualitative work in psychosis, voice hearing was not experienced with a sense of imposition or control. Conclusions: This phenomenological research yielded in-depth and novel accounts of ‘non-psychotic’ voices which were intimately linked to emotional experience. In contrast to standard reports of voices in disorders such as schizophrenia, participants described a complex and bi-directional relationship with their voices. Many other features were in common with voice hearing in psychosis. Knowledge of the phenomenology of hallucinations in non-psychotic disorders has the potential to inform future more successful management strategies. This report gives preliminary evidence for future research.
Intra-Species Mixture Alters Pest and Disease Severity in Cotton

ABSTRACT Widespread planting of crops genetically modified to express Bacillus thuringiensis (Bt) toxins for pest control may potentially affect nontarget pests and soil-borne disease. In this study, a field trial was conducted to explore the effects of habitat diversification, specifically an intraspecies mixture of genetically distinct cotton lines, on nontarget pests and soil-borne disease. It was hypothesized that the mixture would suppress disease severity and would alter pest and predator abundances. Results confirmed that a row-mixture of 75% insect-resistant cotton and 25% disease-resistant cotton suppressed Fusarium wilt and controlled cotton aphids. However, intercropping at the genotypic level increased mirid bug and sweetpotato whitefly densities in cotton. Moreover, the effect of the mixture on predator abundance ranged from neutral to positive and was highly variable among species and years. Species-specific pest responses to the crop mixture provide new insights for optimally sized and configured refuge construction in the future.
Salvia Spp. Essential Oils against the Arboviruses Vector Aedes albopictus (Diptera: Culicidae): Bioactivity, Composition, and Sensorial Profile—Stage 1

Mosquito-borne arboviruses diseases cause a substantial public health burden within their expanding range. To date, their control relies on synthetic insecticides and repellents aimed to control the competent mosquito vectors. However, their use is hampered by their high economic, environmental, and human health impacts. Natural products may represent a valid eco-friendly alternative to chemical pesticides to control mosquitoes, and mosquito-borne parasitic diseases. The aim of this work was to combine the chemical and sensorial profiles with the bioactivity data of Salvia spp. essential oils (EOs) to select the most suitable EO to be used as a repellent and insecticide against the invasive mosquito Aedes albopictus (Diptera: Culicidae), vector of pathogens and parasites, and to describe the EOs smell profile. To do this, the EOs of four Salvia species, namely S. dolomitica, S. dorisiana, S. sclarea, and S. somalensis were extracted, chemically analyzed and tested for their bioactivity as larvicides and repellents against Ae. albopictus. Then, the smell profiles of the EOs were described by a panel of assessors. The LC50 of the EOs ranged from 71.08 to 559.77 μL L−1 for S. dorisiana and S. sclarea, respectively. S. sclarea EO showed the highest repellence among the tested EOs against Ae. albopictus females (RD95 = 12.65 nL cm−2), while the most long-lasting, at the dose of 20 nL cm−2, was S. dorisiana (Complete Protection Time = 43.28 ± 3.43 min). S. sclarea EO showed the best smell profile, while S. dolomitica EO the worst one with a high number of off-flavors. Overall, all the EOs, with the exception of the S. dolomitica one, were indicated as suitable for “environmental protection”, while S. dorisiana and S. sclarea were indicated as suitable also for “Body care”.
A first look at the working alliance in psychotherapy with American Indians.

We could find no published studies measuring the working alliance in outpatient psychotherapy with American Indians. Given that the working alliance has been shown to be one of the most reliable and robust predictors of outcome across psychotherapeutic modalities, we sought to understand the working alliance in this population. Eight psychotherapists in an urban outpatient clinic rated their working alliance with American Indian patients (n = 112) immediately after treatment delivery using the Working Alliance Inventory, 12-item short form (Tracey & Kokotovic, 1989). Working alliance data from 112 sessions were collected and compared with data from the Working Alliance Inventory, 12-item short form, normative sample (Busseri & Tyler, 2003). Therapist-rated working alliance in psychotherapy with American Indian patients was higher than a comparison sample. Alliance was unaffected by patient, therapist, or therapy-related variables in this sample. The working alliance is likely to be an important construct in psychotherapy with American Indian patients. Replication with a larger, representative group of therapists as well as the collection of patient and observer ratings are important next steps. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Pain relief during labor - what do we know and what should we know? research based on the student population in Warsaw.

OBJECTIVE The aim: Women of reproductive age often think of motherhood and labor with fear of intense labor pain. The anxiety they experience can lead to their postponing pregnancy. There are not many studies in the literature that research the knowledge young women have about the analgesia of labor. The aim of the present work was to evaluate the state of awareness about the possible methods of labor analgesia among women of childbearing age. PATIENTS AND METHODS Material and methods: An Internet survey was conducted among 160 women. It consisted of questions on the pharmacological and non-pharmacological methods of labor analgesia. Most of the respondents were not medical university students (96.2%). Correct answers ranged between 11.3% and 97.5% of the total responses. RESULTS Results: The greatest number of incorrect answers were given to the question regarding contraindications to labor anesthesia (only 11.3% of answers were correct). There was also a low percentage of correct answers to questions about the risk of spinal cord injury during the procedure of inducing anesthesia (18.8% of correct answers), the motor activity of a woman after analgesia (22.5%) and the reimbursement of anesthesia (29.4%). Nearly 40% of the respondents did not know the correct answer to the question about the possibility of breastfeeding after anesthesia. The problem of aalgesia during twin delivery also posed a challenge. Over half of the respondents (54.1%) incorrectly answered the question about the occurrence of complications among women who want to become pregnant again after the procedure of labor anesthesia. Moreover, 70.6% of the women surveyed considered non-pharmacological methods of labor anesthesia to be safer compared to pharmacological analgesia. The most commonly mentioned methods of non-pharmacological labor pain relief included breathing techniques and water birth. CONCLUSION Conclusions: The study shows that women of childbearing potential have an unsatisfactory level of knowledge about labor anesthesia. There is a need to improve the level of health education on this topic.