Miracle-dz/UniFAR-FTUs huggingface dataset:
Killer Cell Immunoglobulin-like Receptors (KIR) and Human Leucocyte Antigen C (HLA-C) Increase the Risk of Long-Term Chronic Liver Graft Rejection

Chronic liver rejection (CR) represents a complex clinical situation because many patients do not respond to increased immunosuppression. Killer cell immunoglobulin-like receptors/Class I Human Leukocyte Antigens (KIR/HLA-I) interactions allow for predicting Natural Killer (NK) cell alloreactivity and influence the acute rejection of liver allograft. However, its meaning in CR liver graft remains controversial. KIR and HLA genotypes were studied in 513 liver transplants using sequence-specific oligonucleotides (PCR-SSO) methods. KIRs, human leucocyte antigen C (HLA-C) genotypes, KIR gene mismatches, and the KIR/HLA-ligand were analyzed and compared in overall transplants with CR (n = 35) and no-chronic rejection (NCR = 478). Activating KIR (aKIR) genes in recipients (rKIR2DS2+ and rKIR2DS3+) increased CR compared with NCR groups (p = 0.013 and p = 0.038). The inhibitory KIR (iKIR) genes in recipients rKIR2DL2+ significantly increased the CR rate compared with their absence (9.1% vs. 3.7%, p = 0.020). KIR2DL3 significantly increases CR (13.1% vs. 5.2%; p = 0.008). There was no influence on NCR. CR was observed in HLA-I mismatches (MM). The absence of donor (d) HLA-C2 ligand (dC2−) ligand increases CR concerning their presence (13.1% vs. 5.6%; p = 0.018). A significant increase of CR was observed in rKIR2DL3+/dC1− (p = 0.015), rKIR2DS4/dC1− (p = 0.014) and rKIR2DL3+/rKIR2DS4+/dC1− (p = 0.006). Long-term patient survival was significantly lower in rKIR2DS1+rKIR2DS4+/dC1− at 5–10 years post-transplant. This study shows the influence of rKIR/dHLA-C combinations and aKIR gene-gene mismatches in increasing CR and KIR2DS1+/C1-ligands and the influence of KIR2DS4+/C1-ligands in long-term graft survival.
Simple germs of corank one affine distributions

1.1. Affine distributions. All objects are assumed to be smooth (of class C∞). An affine distribution on R of rank m (or corank n − m) is a family A = {Ap}p∈Rn of m-dimensional affine subspaces Ap ⊂ TpR. If Ap is a subspace, i.e., Ap contains the zero tangent vector, then p is called an equilibrium point of A. Two germs A and A of corank one affine distributions, at points p and p respectively, are equivalent if there exists a local diffeomorphism Φ sending p to p such that Φ∗(Ax) = AΦ(x) for each x close to p.
Proteins from Modern and Ancient Wheat Cultivars: Impact on Immune Cells of Healthy Individuals and Patients with NCGS

In non-celiac gluten sensitivity (NCGS), the elimination of wheat results in a clear symptom improvement, but gluten has still not been proven as (the sole) trigger. Due to the increase in the prevalence of gluten-related diseases, the breeding of high-performance wheat cultivars is discussed as a trigger. To analyze the immune stimulation and signal pathways, the immune cells of healthy subjects and patients with NCGS were stimulated with gliadins from wheat, and the expression and secretion of interleukin 1ß (IL1ß) and interleukin 6 (IL6) were studied. To determine the impact of wheat breeding, the monocyte cell line THP1 and human immune cells were stimulated with gliadin, glutenin, and albumin/globulin fractions of ancient and modern cereals, and expression of inflammatory molecules was checked. Immune cells of patients with NCGS showed an increased expression of IL1ß and IL6 after stimulation with gliadins compared to immune cells of healthy controls. Gliadins caused a strong activation of P-STAT3 in immune cells of healthy controls, and inhibitors of JAK and NFκB pathways considerably reduced this response. In addition to gliadins, we further showed that glutenins and albumin/globulins from all wheat cultivars from the last century, and especially from einkorn and spelt, also markedly induced the expression of inflammatory genes in THP1 and human immune cells. There was no correlation between enhanced immune stimulation and ancient or modern cultivars. This does not support the hypothesis that modern wheat breeding is responsible for the increase in gluten-related diseases. An altered immune situation is suggested in patients with NCGS.
Impact of Audit Quality on Stock Price Crash Risk: Evidence from Pakistan Stock Exchange

Stock price crash risk is an unfavourable event in business that may decrease the shareholder’s wealth and hurt stability and capital market growth. This study investigates the impact of audit quality measured by auditor industry specialization (AIS), audit tenure (AT), audit committee independence (ACI), audit firm size(AFS)) on stock value crash (measured by down-to-up unpredictability) for a sample of 70 non-financial firms listed in Pakistan Stock Exchange during from 2009 to 2018. Efficient governance enriches financial and operational directness, which cuts down the stock value crashes in rotation. Facing crash risk difficulties, traders impart more funds to stocks of well-regime organizations. The fixed effect model results show that AIS and ACI have a negative and significant impact on crash risk, while there is a positive impact of AFS on stock price crash risk. Moreover, it concludes that it has an insignificant impact on stock price crash risk in Pakistan. It is concluded that effective audit quality lessens the difficulty of data abnormality and improves stock price crash risk. This study has importance for investors to help them identify the most liquid stock and will enable them to decide which stocks to acquire and which to dispose of. This study will also be helpful for academics and scholars to bridge this gap on the influence of audit quality practices on the economic consequences of Pakistan. It will be useful for future research as well as because it will become part of the empirical literature on the economic consequence of stock markets.
On the Global Structure of Deformed Yang-Mills Theory and QCD(adj) on $\mathbb R^3 \times \mathbb S^1$

Spatial compactification on $\mathbb R^{3} \times \mathbb S^1_L$ at small $\mathbb S^1$-size $L$ often leads to a calculable vacuum structure, where various "topological molecules" are responsible for confinement and the realization of the center and discrete chiral symmetries. Within this semiclassically calculable framework, we study how distinct theories with the same $SU(N_c)/\mathbb Z_k$ gauge group (labeled by "discrete $\theta$-angles") arise upon gauging of appropriate $\mathbb Z_k$ subgroups of the one-form global center symmetry of an $SU(N_c)$ gauge theory. We determine the possible $\mathbb Z_k$ actions on the local electric and magnetic effective degrees of freedom, find the ground states, and use domain walls and confining strings to give a physical picture of the vacuum structure of the different $SU(N_c)/\mathbb Z_k$ theories. Some of our results reproduce ones from earlier supersymmetric studies, but most are new and do not invoke supersymmetry. We also study a further finite-temperature compactification to $\mathbb R^{2}\times \mathbb S^1_\beta\times\mathbb S^1_L$. We argue that, in deformed Yang-Mills theory, the effective theory near the deconfinement temperature $\beta_c \gg L$ exhibits an emergent Kramers-Wannier duality and that it exchanges high- and low-temperature theories with different global structure, sharing features with both the Ising model and $S$-duality in ${\cal N}$$=$$4$ supersymmetric Yang-Mills theory.
The Clusters AgeS Experiment (CASE). VI. Analysis of two detached eclipsing binaries in the Globular Cluster M55

We present an analysis of the detached eclipsing binaries V44 and V54 belonging to the globular cluster M55. For V54 we obtain the following absolute parameters: $M_p=0.726\pm 0.015\,M_\odot$, $R_p=1.006\pm 0.009\,R_\odot$, $L_p=1.38\pm 0.07\,L_\odot$ for the primary, and $M_s=0.555\pm 0.008\,M_\odot$, $R_s=0.528\pm 0.005\,R_\odot$, $L_s=0.16\pm0.01\,L_\odot$ for the secondary. The age and apparent distance modulus of V54 are estimated at 13.3 - 14.7 Gyr and $13.94\pm0.05$ mag, respectively. This age is substantially larger than ages we have derived from the analysis of binary systems in 47 Tuc and M4. The secondary of V44 is so weak in the optical domain that only mass function and relative parameters are obtained for the components of this system. However, there is a good chance that the velocity curve of the secondary could be derived from near-IR spectra. As the primary of V44 is more evolved than that of V54, such data would impose much tighter limits on the age and distance of M55.
Seeing Reason: Image and language in learning to think

1. Introduction 2. Language, diagram and system 3. Hyperproof: industrial strength logic teaching 4. Euler and the syllogism: back to the age of reason 5. Why do we have to learn logic? A paradox resolved 6. Interpretation, reasoning, and communication 7. Cards and dice: assessing evidence and understanding experimenters 8. The proof of a power station is in the.diagrams and equations for practitioners 9. Involvement and detachment in learning to communicate 10. Bloor, Lakatos and the sociology of diagrams 11. Conclusions for practice 12. Conclusions for theory
Public Gender Egalitarianism: A Dataset of Dynamic Comparative Public Opinion toward Egalitarian Gender Roles in the Public Sphere

Abstract Societal attitudes toward gender roles in the workplace and politics play a central part in theorizing on the difficulty women face in achieving political equality, but shortcomings in the available data have prevented direct examination of many implications of these theories. Drawing on recent advances in latent-variable modeling of public opinion and a comprehensive collection of survey data, we present the Public Gender Egalitarianism dataset to address this need: comparable estimates of the public's attitudes on gender equality in the public sphere across more than one hundred countries over time. These Public Gender Egalitarianism scores are strongly correlated with responses to individual survey items and with women's rates of participation in the labor force and corporate boards. We expect that the Public Gender Egalitarianism data will become an invaluable source for broadly cross-national and longitudinal research on the causes and consequences of collective attitudes toward gender equality in politics and the economy.
Algorithmic algebraic number theory

Preface List of symbols 1. Basics of constructive algebraic number theory 2. The group of an equation 3. Methods from the geometry of numbers 4. Embedding of commutative orders into the maximal order 5. Units in algebraic number fields 6. The class group of algebraic number fields Appendix Algorithms References Index.
Inflationary infrared divergences: geometry of the reheating surface vs. δN formalism

We describe a simple way of incorporating fluctuations of the Hubble scale during the horizon exit of scalar perturbations into the delta N formalism. The dominant effect comes from the dependence of the Hubble scale on low-frequency modes of the inflaton. This modifies the coefficient of the log-enhanced term appearing in the curvature spectrum at second order in field fluctuations. With this modification, the relevant coefficient turns out to be proportional to the second derivative of the tree-level spectrum with respect to the inflaton. at horizon exit. A logarithm with precisely the same coefficient appears in a calculation of the log-enhancement of the curvature spectrum based purely on the geometry of the reheating surface. We take this agreement as strong support for the proposed implementation of the dN formalism. Moreover, our analysis makes it apparent that the log-enhancement of the inflationary power-spectrum is indeed physical if this quantity is defined using a global coordinate system on the reheating surface (or any other post-inflationary surface of constant energy density). However, it can be avoided by defining the spectrum using invariant distances on this surface.
The Very Large Telescope Lyman-Break Galaxy Redshift Survey – IV. Gas and galaxies at z ∼ 3 in observations and simulations

We use a combination of observations and simulation to study the relationship between star-forming galaxies and the intergalactic medium at z ≈ 3. The observed star-forming galaxy sample is based on spectroscopic redshift data taken from a combination of Very Large Telescope (VLT) Lyman-break galaxy (LBG) Redshift Survey (VLRS) data and Keck Low-Resolution Imaging Spectrometer (LRIS) observations in fields centred on bright background quasi-stellar objects (QSOs), whilst the simulation data is taken from the Galaxies–Intergalactic Medium Interaction Calculation (GIMIC). In the simulation, we find that the dominant peculiar velocities are in the form of large-scale coherent motions of gas and galaxies. Gravitational infall of galaxies towards one another is also seen, consistent with expectations from linear theory. At smaller scales, the root-mean-square (RMS) peculiar velocities in the simulation overpredict the difference between the simulated real- and z-space galaxy correlation functions. Peculiar velocity pairs with separations smaller than 1 h−1 Mpc have a smaller dispersion and explain the z-space correlation function better. The Lyα auto- and cross-correlation functions in the GIMIC simulation appear to show infall smaller than implied by the expected βLyα ≈ 1.3 (McDonald et al.). There is a possibility that the reduced infall may be due to the galaxy-wide outflows implemented in the simulation. The main challenge in comparing these simulated results with the observed Keck + VLRS correlation functions comes from the presence of velocity errors for the observed LBGs, which dominate at ≲ 1 h− 1 Mpc scales. When these are taken into account, the observed LBG correlation functions are well matched by the high amplitude of clustering, shown by higher mass (M* > 109 M⊙) galaxies in the simulation. The simulated cross-correlation function shows similar neutral gas densities around galaxies to those seen in the observations. The simulated and observed Lyα z-space autocorrelation functions again agree better with each other than with the βLyα ≈ 1.3 infall model. Our overall conclusion is that, at least in the simulation, gas and galaxy peculiar velocities are generally towards the low end of expectation. Finally, little direct evidence is seen in either simulation or observations for high transmission near galaxies due to feedback, in agreement with previous results.
Zero lower bound term structure modeling : a practitioner's guide

Chapter 1: Introduction Chapter 2: A New Framework for a New Environment Chapter 3: Gaussian Affine Term Structure Models Chapter 4: Krippner Framework for ZLB Term Structure Modeling Chapter 5: Black Framework for ZLB Term Structure Modeling Chapter 6: K-ANSM Foundations and "Effective Monetary Stimulus" Chapter 7: Monetary Policy Applications Chapter 8: Financial Market Applications Chapter 9: Conclusions and Future Research Directions Appendix A: Matrix Notation
HYDRODYNAMIC THEORIES OF SHIP SLAMMING: REVIEW AND EXTENSION

A critical review and evaluation of existing hydrodynamic theories of body-water impact is presented. It is shown, partly by comparison with available experimental data, that current fitting methods are adequate only for bodies of reasonably large deadrise angle, particularly during the later stages of the impact process. An improved ellipse-fitting technique is presented that extends to a much broader class of body forms and derives more accurate formulations of the general problem. The refined technique avoids linearization of the free surface boundary condition and accounts for compressibility effects during the initial stage of impact. It is concluded that similar refined methods of predicting slamming pressures are necessary not only for critical ship design problems but also for the assessment of approximate theories used in studies of slamming characteristics of various ship forms.
Evaluation of the effectiveness of greentherapy on discretion and executive functions in hyperactive children

This study was conducted with the aim of investigating the effectiveness of green therapy on the decision-making power and executive functions of hyperactive children. Materials and methods: This study was conducted as a semi-experimental study with a pre-test-post-test design. The statistical population included all 7-9-year-old hyperactive students living in Tehran in the academic year 2021-2022. Based on the objectives of the research, 31 hyperactive children were selected by available sampling method and using Connors test, and they were randomly divided into two experimental groups (15) and control group (16). Then they were evaluated by the Cambridge Neuropsychological Test (CANTAB). Parents of experimental group members were trained. Children also received the intervention for 14 sessions of 60 minutes (2 sessions per week), while the control group did not benefit from this intervention during the research process. After completing the treatment sessions, both groups underwent a post-test. After data collection, data analysis was done by statistical analysis of covariance using SPSS21 software package. The results showed that there is a significant difference between the post-test and pre-test scores of the experimental group compared to the control group.
Narratives by bilingual children: a tale of strengths and growth during kindergarten

ABSTRACT Given their significance in daily life and frequent inclusion in clinical and educational assessments, children’s narrative abilities merit investigation. The present study examines the narratives of children acquiring an additional language, adding to the more abundant studies of monolingual children. Sixty kindergartners (mean age 68 months) residing in Quebec, Canada participated. All spoke a minoritized language at home, and were being instructed in French, the majority language, at school. The children told stories in French based on pictures from the Edmonton Narrative Norms Instrument (Schneider, Dubé, and Hayward, 2005) in late fall or early winter, and again in spring. Their stories were subsequently analyzed for their macrostructural features. Despite limited exposure to French prior to kindergarten, the majority of children were able to communicate the central problem in the story, characters’ attempts to resolve the problem, and outcomes of those attempts. Furthermore, the children’s scores increased from time 1 to time 2 overall, and for four of eight story grammar elements. The higher scores were due to higher scores on elements as well as the emergence of new elements in children’s stories at time 2. The findings can help guide expectations for narrative growth among emerging bilingual children and inform instruction.
A New Decision-Making GMDH Neural Network: Effective for Limited and Fuzzy Data

This paper presents a new approach to solve multi-objective decision-making (DM) problems based on neural networks (NN). The utility evaluation function is estimated using the proposed group method of data handling (GMDH) NN. A series of training data is obtained based on a limited number of initial solutions to train the NN. The NN parameters are adjusted based on the error propagation training method and unscented Kalman filter (UKF). The designed DM is used in solving the practical problem, showing that the proposed method is very effective and gives favorable results, under limited fuzzy data. Also, the results of the proposed method are compared with some similar methods.
Are online reviews credible? The effects of online reviews for the adoption of MOOCs for E-learning

ABSTRACT The proliferation of massive open online courses (MOOCs) has sped up the evolution of online education. People now have a habit of checking internet reviews before deciding on and enrolling in an MOOC. However, issues about the veracity of online reviews have grown in significance. The S-O-R framework was used to determine the factors that have an impact on the reliability of reviews of MOOCs. The current study uses dual process theory (DPT) as a theoretical framework for identifying the stimuli. This finding reveals that review consistency and overall rating are more important in influencing the adoption of MOOC than the various informational factors. The findings also highlight that informal online communication (online reviews) is crucial to the adoption of e-learning.
Assembly of Biologically Functional Structures by Nucleic Acid Templating: Implementation of a Strategy to Overcome Inhibition by Template Excess

Delivery of therapeutic molecules to pathogenic cells is often hampered by unintended toxicity to normal cells. In principle, this problem can be circumvented if the therapeutic effector molecule is split into two inactive components, and only assembled on or within the target cell itself. Such an in situ process can be realized by exploiting target-specific molecules as templates to direct proximity-enhanced assembly. Modified nucleic acids carrying inert precursor fragments can be designed to co-hybridize on a target-specific template nucleic acid, such that the enforced proximity accelerates assembly of a functional molecule for antibody recognition. We demonstrate the in vitro feasibility of this adaptation of nucleic acid-templated synthesis (NATS) using oligonucleotides bearing modified peptides (“haplomers”), for templated assembly of a mimotope recognized by the therapeutic antibody trastuzumab. Enforced proximity promotes mimotope assembly via traceless native chemical ligation. Nevertheless, titration of participating haplomers through template excess is a potential limitation of trimolecular NATS. In order to overcome this problem, we devised a strategy where haplomer hybridization can only occur in the presence of target, without being subject to titration effects. This generalizable NATS modification may find future applications in enabling directed targeting of pathological cells.
Schottky uniformizations of Automorphisms of Riemann surfaces

It is well known that the collection of uniformizations of a closed Riemann surface $S$ is partially ordered; the lowest ones are the Schottky unformizations, that is, tuples $(\Omega,\Gamma,P:\Omega \to S)$, where $\Gamma$ is a Schottky group with region of discontinuity $\Omega$ and $P:\Omega \to S$ is a regular holomorphic cover map with $\Gamma$ as its deck group. Let $\tau:S \to S$ be a conformal (respectively, anticonformal) automorphism of $S$ of finite order $n$, and let $(\Omega,\Gamma,P:\Omega \to S)$ be a Schottky uniformization of $S$. Assume that $\tau$ lifts with respect to the previous Schottky uniformization, that is, there exists a M\"obius (respectively, extended M\"obius) transformation $\kappa$, keeping $\Omega$ invariant, with $P \circ \kappa=\tau \circ P$. The Kleinian (respectively, extended Kleinian) group $K= $ contains $\Gamma$ as a finite index normal subgroup and $K/\Gamma \cong {\mathbb Z}_{n}$. We provide a structural picture of $K$ in terms of the Klein-Maskit's combination theorems and some basic groups. Some consequences are (i) the determination of the number of topologically different types of such groups (fixed $n$ and the rank of the Schottky normal subgroup) and (ii) for $n$ prime, the number of normal Schottky normal subgroups, up to conjugacy, that $K$ has.