Miracle-dz/UniFAR-FTUs huggingface dataset:
Bromodomain Containing Protein 4 (BRD4) Regulates Expression of its Interacting Coactivators in the Innate Response to Respiratory Syncytial Virus

Bromodomain-containing protein 4 plays a central role in coordinating the complex epigenetic component of the innate immune response. Previous studies implicated BRD4 as a component of a chromatin-modifying complex that is dynamically recruited to a network of protective cytokines by binding activated transcription factors, polymerases, and histones to trigger their rapid expression via transcriptional elongation. Our previous study extended our understanding of the airway epithelial BRD4 interactome by identifying over 100 functionally important coactivators and transcription factors, whose association is induced by respiratory syncytial virus (RSV) infection. RSV is an etiological agent of recurrent respiratory tract infections associated with exacerbations of chronic obstructive pulmonary disease. Using a highly selective small-molecule BRD4 inhibitor (ZL0454) developed by us, we extend these findings to identify the gene regulatory network dependent on BRD4 bromodomain (BD) interactions. Human small airway epithelial cells were infected in the absence or presence of ZL0454, and gene expression profiling was performed. A highly reproducible dataset was obtained which indicated that BRD4 mediates both activation and repression of RSV-inducible gene regulatory networks controlling cytokine expression, interferon (IFN) production, and extracellular matrix remodeling. Index genes of functionally significant clusters were validated independently. We discover that BRD4 regulates the expression of its own gene during the innate immune response. Interestingly, BRD4 activates the expression of NFκB/RelA, a coactivator that binds to BRD4 in a BD-dependent manner. We extend this finding to show that BRD4 also regulates other components of its functional interactome, including the Mediator (Med) coactivator complex and the SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) subunits. To provide further insight into mechanisms for BRD4 in RSV expression, we mapped 7,845 RSV-inducible Tn5 transposase peaks onto the BRD4-dependent gene bodies. These were located in promoters and introns of cytostructural and extracellular matrix (ECM) formation genes. These data indicate that BRD4 mediates the dynamic response of airway epithelial cells to RNA infection by modulating the expression of its coactivators, controlling the expression of host defense mechanisms and remodeling genes through changes in promoter accessibility.
Sex-Disparity in the Association Between Birthweight and Cardiovascular Parameters in 4-Year-Old Children: A Chinese Cohort Study

Background: Sex-related differences in cardiovascular parameters have been well documented in adults, and the impact of birthweight on cardiovascular health in later life has been acknowledged. However, data was limited regarding the association between birthweight and cardiovascular outcomes at an early age, and the sex-disparity in the association remained unclear. Objective: To investigate the association between birthweight and cardiovascular parameters in 4-year-old children. Furthermore, to explore whether sex-disparity exist in this association or in cardiovascular risk. Methods: Follow-up data from the Shanghai Birth Cohort (SBC) was analyzed. Detailed perinatal information including both maternal and offspring datum were recorded. Blood pressure, echocardiography, and anthropometry assessment were conducted during the follow-up of 4-year-old children. Linear regression models were used to analyze the association between birthweight and left ventricle (LV) structure and function changes in each sex and birthweight category. Multivariable logistic regression models were used to compare risk of left ventricular hypertrophy (LVH) in different birthweight subgroups. Results: Overall, macrosomia was significantly associated with thickened LV posterior wall thickness in systole [LVPWs, (β = 0.26, 95% CI: 0.06, 0.45)] and diastole [LVPWd, (β = 0.18, 95% CI: 0.06, 0.30)], and thickened interventricular septal thickness in diastole [IVSd, (β = 0.16, 95% CI: 0.05, 0.28)]. Boys with macrosomia showed a higher left ventricle mass index [LVMI, (β = 1.29, 95% CI: 0.14, 2.43)], thickened LVPWs (β = 0.30, 95% CI: 0.05, 0.56) and LVPWd (β = 0.21, 95% CI: 0.06, 0.36), and thickened IVSd (β = 0.23, 95% CI: 0.09, 0.36). However, no significant association of structural changes was found in girls. Furthermore, an increased risk of LVH was found solely in macrosomic boys (OR = 2.79, 95% CI: 1.17, 6.63). Conclusion: Children with macrosomia developed cardiovascular changes as early as 4 years of age. Macrosomia was associated with LV structural changes and higher LVH risk in pre-school-aged boys, while no association was found in girls.
Risk for Cardiovascular Disease and One-Year Mortality in Patients With Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Syndrome Overlap Syndrome

Background: Patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSAS) overlap syndrome (OS) are thought to be at increased risk for cardiovascular diseases. Objective: To evaluate the burden of cardiovascular diseases and long-term outcomes in patients with OS. Methods: This was a retrospective cohort study. The prevalence of cardiovascular diseases and 1-year mortality were compared among patients diagnosed with OS (OS group), COPD alone (COPD group) and OSAS alone (OSAS group), and Cox proportional hazards models were used to assess independent risk factors for all-cause mortality. Results: Overall, patients with OS were at higher risk for pulmonary hypertension (PH), heart failure and all-cause mortality than patients with COPD or OSAS (all p < 0.05). In multivariate Cox regression analysis, the Charlson comorbidity index (CCI) score [adjusted hazard ratio (aHR): 1.273 (1.050–1.543); p = 0.014], hypertension [aHR: 2.006 (1.005–4.004); p = 0.048], pulmonary thromboembolism (PTE) [aHR: 4.774 (1.335–17.079); p = 0.016] and heart failure [aHR: 3.067 (1.521–6.185); p = 0.002] were found to be independent risk factors for 1-year all-cause mortality. Conclusion: Patients with OS had an increased risk for cardiovascular diseases and 1-year mortality. More efforts are needed to identify the causal relationship between OS and cardiovascular diseases, promoting risk stratification and the management of these patients.
Self-reported cataract surgery and 10-year all-cause and cause-specific mortality: findings from the National Health and Nutrition Examination Survey

Purpose To investigate the association of self-reported cataract surgery with all-cause and cause-specific mortality using a large-scale population-based sample. Methods Data from the 1999–2008 cycles of the National Health and Nutrition Examination Survey were used. A self-reported history of cataract surgery was considered a surrogate for the presence of clinically significant cataract surgery. Mortality data were ascertained from National Death Index records. Hazard ratios (HRs) and 95% confidence intervals (CIs) for survival were estimated using Cox proportional hazards regression models. Results A total of 14 918 participants were included in the analysis. During a median follow-up of 10.8 (Interquartile range, IQR, 8.25–13.7) years, 3966 (19.1%) participants died. Participants with self-reported cataract surgery were more likely to die from all causes and specific causes (vascular disease, cancer, accident, Alzheimer’s disease, respiratory disease, renal disease and others) compared with those without (all Ps <0.05). The association between self-reported cataract surgery and all-cause mortality remained significant after multiple adjustments (HR=1.13; 95% CI 1.01 to 1.26). For cause-specific mortality, multivariable Cox models showed that self-reported cataract surgery predicted a 36% higher risk of vascular-related mortality (HR=1.36; 95% CI 1.01 to 1.82). The association with other specific causes of mortality did not reach statistical significance after multiple adjustments. Conclusions This study found significant associations of self-reported cataract surgery with all-cause and vascular mortalities. Our findings provide potential insights into the pathogenic pathways underlying cataract.
Efficiency of foliar application by chitosan and royal jelly on growth, yield and quality of two garlic cultivars

This study was conducted to evaluate the potential effect of foliar spray with different doses of two bio-stimulants Chitosan (CS) and Royal Jelly (RJ) on growth and yield and quality of two garlic cultivars (Egaseed1 and Balady i.e(Egyptian) at two winter seasons of 2017/2018 and 2018/2019.Generally, the foliar spray of all tested biostimulates treatments considerably improves almost all plant growth traits of garlic cultivars which reflected on plants yield and quality. Data showed that spraying Ega1 plants with different doses of CS and RJ considerably increased total yield (TY) in both seasons as compared with control (13.39 and 14.64 tons). The highest values of TY were found in Ega1 plants treated with 0.1g/l RJ (15.29 and 15.80 tons) and 0.3g/l RJ (15.08 and 16.61 tons) at both seasons respectively. On the other side, there was clear increase in TY of Egy plants treated with different CS and RJ doses at both seasons as compared with control (7.57 and 8.69 tons, respectively). The highest values of TY were found in Egy. plants treated with 0.2g/L RJ (9.23 and 8.53 tons) at both seasons respectively as compared with all other treatments. As compared to control, foliar spray with CS and RJ reduced weight loss % and deterioration of bulbs during storage. In general, foliar application of chitosan (1000 and 1500 ppm) and Royal Jelly (0.2 and 0.3 g.L -1 ) could be recommended to improve productivity, quality and storability of the two garlic cultivars grown under Minia Governorate conditions.
The Seasonal Fluctuations of Phytoplankton Diversity and its Biochemical Components in Lake Qarun, Egypt

Based on historic and scientific importance, Lake Qarun is considered a unique ecosystem. It is a natural reservoir in Fayoum depression, receiving its water from two main drains; namely, El-Bats drain (at the north-eastern corner) and El-Wadi drain (at the midpoint of the southern shore). Hussein et al. (2008) reported that Lake Qarun suffers from severe pollution problems due to different domestic and industrial waste drainage, even though it was classified as a protected area back in 1989. Several studies were carried out to investigate seasonal and temporal effects on phytoplankton community and assemblage in Lake Qarun, and the prevalent finding was that phytoplankton was normally flourished in spring and summer, while lower algae density was observed in autumn and winter (Abdel-Monem & Kanswa, 2001; Fathi & Flower, 2005; Hussian et al., 2019). Physiological and nutritional condition of ARTICLE INFO ABSTRACT Article History: Received: June 1, 2021 Accepted: Aug. 27, 2021 Online: Sept. 18, 2021 _______________
Phonological Processing and other Language Parameters in ADHD Children

Background: Attention Deficit Hyperactivity Disorder (ADHD) refers to the existence of marked difficulties in terms of distractibility, impairment of attention and hyperactivity with a subsequent development of substantial impairment in academic and social functioning. Language impairment (LI)is a predominant co-morbidity in pediatrics with psychiatric illnesses and behavioral troubles. In children with LI, one of the common psychiatric disorders is ADHD. However, LI is a common co-morbidity which often could be detected in ADHD children. Although language problems are not among the main symptoms or needed to fulfill current diagnostic criteria of ADHD, most ADHD children have additional defects in language skills. Objective: The main purpose of the current study was to assess language profile in ADHD children at school age and to specify aspects of language defect in comparison with their normal peers. Patients and Methods: 60 children in the school age (6-10 years) of both genders divided in to two groups, case group: 30 children with ADHD and control group: 30 children without ADHD were enrolled in this case control study. Children were assessed by study tests: 1Stanford Binet [fifth edition], 2ADHD Test 3REAL Scale, 4Phonological Awareness Test, 5Rapid Automatized Naming Test. Results: ADHD children were lower than their normal peers in IQ score, language skills, phonological awareness skills, and rapid automatized naming. Regarding aspects of language, they had defects in many skills: receptive and expressive vocabulary, morphosyntax, sentence comprehension, story comprehension, verbal categorization, sentence repetition, and forming sentences.
SUCCESSION PATTERN OF INSECT OF FORENSIC IMPORTANCE ON RABBIT CARRION AT THREE LOCATIONS IN FEDERAL COLLEGE OF FORESTRY OF JOS, PLATEAU STATE, NIGERIA

The objective of this study was to identify insects species visiting decomposing rabbit carrion and to establish the relationship between insects and decomposing carrion which may be of forensic importance in Jos, Plateau state Nigeria. Six rabbit weighing between 2.3kg and 2.7kg were killed by a sharp blow with a blunt metal object on the heads. Two each of the six rabbit were exposed to the sun, under shade and near river. The carcasses were allowed to decompose and insect were collected twice a day for the first one week and thereafter once a day up to the end of the 15 weeks. Four decomposition stages recorded were fresh, bloating, decay and post decay stages. A total of 16 insect species from 7 families and 3 orders were observed. Three Diptera families (Calliphoridae, Muscidae and Sarcophagidae) were identified from carcasses in all the locations and they were the first to be observed. Species collected included Lucilia Cuprina, Chrymosya albiceps, Chrymosya megacephala, Phormiaregina, Musca domestica and Hydrotaea sp. Three Coleopteran families (Cleridae, Silphidae and Dermestidae) were identified from all the carcasses and the observed species were Necrobia rufipes, Necrophile rufithorax and Dermestes muculatus. Hymenoptera (Formicidae) was also present throughout the period. The study shows that insects from the order Diptera (Calliphoridae and Muscidae) indicate the fresh and bloat stage, while the order Coleopteran (Dermestidae) indicate the decay and post decay stage during period of decomposition of the carcasses and could be of importance for further forensic studies since they were collected from the carcasses.
Using the Wikipedia Game to Play Trivia Games

A common theme across diﬀerent factoid question answering methods is to by some means compute the semantic similarity between questions and potential answers and then select the answer with the highest similarity to the question text. A common way to compute this score is to embed the questions and answers in either traditional or neural bag of words vector space, and then rank all possible answers with a machine learned model. In this work we introduce network based methods for using the Wikipedia hyperlink graph to compute an initial list of candidate answers, network-based ranking metrics for ordering these candidates, and text based word embedding methods that are also shown to be eﬀective for ranking using only the page title and question text.
Alliance Recommendations to Establish Quality in Egyptian Higher Education VLEs

This research aims to identify quality in VLEs (Virtual Learning Environments), describes the development of a model, based on original research, describing the characteristics associated with the successful deployment of technology evidenced in the Egyptian higher education, and the alliance factors related to such implementation of quality in VLE. Research findings clarify the importance of quality for the accreditation of VLEs and demonstrate the proposed model that, based on the motivations arising from the challenges: improving the quality of learning, identify the possible stakeholders in determining the quality of VLEs, improving access to teaching and learning, and reducing the costs for providers. The suggested model incorporates: stakeholders' satisfaction; learning outcomes; environment facilities; and evaluation during development. The findings also revealed groups of Recommendations for VLEs' participants, designers, and administration to accomplish quality in VLEs.
Pedigree selection in sesame under artificial infection of Fusarium oxysporum f. sp. sesami

Fusarium is one of the most dangerous fungal diseases that cause great loss of the sesame yield worldwide. The present work aimed to improve tolerance and/or resistance to Fusarium through two cycles of pedigree selection on sesame population for eight selection criteria started in the F3-generation. Genotypic coefficient of variability in the F3 varied from 4.34% for days to 50% flowering to 38.15% for seed yield (SY/P). Days to 50% flowering showed negative correlations with all traits except height to first capsule (HFC). Height to first capsule was negatively correlated with length of fruiting zone (LFZ), 1000-SW, oil% and infection%, and positively correlated with capsules/plant (NC/P) and SY/P. Single trait selection was an efficient method to improve selection criterion, but it caused adverse effects on some correlated traits. Selection for days to 50% flowering improved earliness, but it was better in improving yield if the selection was restricted by SY/P. Selection for oil% restricted by yield was better in improving yield than selection for oil% per se. Therefore, the inclusion of a trait as independent culling level improved the efficiency of selection. The best genetic gain in SY/P in percentage from the mid-parent was obtained from selection for days to 50% flowering restricted by SY/P (35.56 ** ), LFZ restricted by HFC (19.53 ** ), days to 50% flowering (19.32 ** ), oil% restricted by SY/P (19.02 ** ), SY/P (17.38 ** ), 1000 SW (14.09 ** ) and LFZ (14.032 ** ). Therefore, selection index incorporating favorable trait is recommended.
Integrating Technology that Uses Modified SAMR Model as a Pedagogical Framework in Evaluating Learning Performance of Undergraduates

This is a case study on the integration of technology using a modified SAMR (Substitution, Augmentation, Modification, Redefinition) model as a pedagogical framework in teaching and learning in a private college in Melaka, Malaysia on a chosen topic in Business Communication. The study was conducted in Summer, 2019. This is a quantitative study with two groups which are control and experimental groups. The control group had gone through the traditional teaching method while the experimental group learned through technology. The model was incorporated with Bloom’s Taxonomy and TPACK for credibility and reliability. All four stages of the SAMR Model were investigated for the presence of content, pe-dagogy, and technology. The study identified that there was the presence of content, pedagogy, and technology in the stages of augmentation, modification, and redefinition while pedagogy and content were absent in the substitution level. However, the integration of technology using the proposed pedagogical framework improved student performance in the last three stages of augmentation, modification, and redefinition with positive results. Overall, the study has evidence that the modified SAMR Model had enhanced and improved student performance. It is hoped that the outcome of this research provides valuable insight and guidance to those who want to integrate technology into the teaching and learning process.
Poset matrix and recognition of series-parallel posets

We introduce the notion of poset matrix for representing ﬁnite partially ordered sets (posets). We study the interpretations of diﬀerent forms of poset matrix. We show that every poset matrix can be re-labeled to upper (equivalently lower) triangular form representing a unique poset up to isomorphism. We also show that the direct sum and ordinal sum of poset matrices represent the direct sum and ordinal sum of posets respectively. We deﬁne the properties of block of 0s, block of 1s and complete blocks of 1s on poset matrix and give an application of poset matrix in recognizing series-parallel posets.
Hierarchical Layout Synthesis and Optimization Framework for High-Density Power Module Design Automation

Multi-chip power module (MCPM) layout design automation has become an emerging research field in the power electronics society. MCPM physical design is currently a trial-and-error procedure that heavily relies on the designers' experience to produce a reliable solution. To push the boundary of energy efficiency and power density, novel packaging technologies are emerging with increasing design complexity. As this manual design process becomes the bottleneck in design productivity, the power electronics industry is calling for more intelligence in design CAD tools, especially for advanced packaging solutions with stacked substrates. This paper presents a physical design, synthesis, and optimization framework for 2D, 2.5D, and 3D power modules. Generic, scalable, and efficient physical design algorithms are implemented with optimization metaheuristics to solve the hierarchical layout synthesis problem. Corner stitching data structure and hierarchical constraint graph evaluation have been customized to better align with power electronics design considerations. A complete layout synthesis process is demonstrated for both 2D and 3D power module examples. Further, electro-thermal design optimization is carried out on a sample 3D MCPM layout using both exhaustive and evolutionary search methods. Our algorithm can generate 937 3D layouts in 56 s, resulting in 10 layouts on the Pareto-front. In addition, our optimized 3D layouts can achieve 1.3 nH loop inductance with 38 °C temperature rise and 836 mm2 footprint area, compared to 2D layouts with 8.5 nH, 99 °C, and 2000 mm2.
Applications of Metric Space Magnitude to Machine Learning via Boundary Detection

Metric space magnitude, an active subject of research in algebraic topology, originally arose in the context of biology, where it was used to represent the effective number of distinct species in an environment. In a more general setting, the magnitude of a metric space is a real number that aims to quantify the effective number of distinct points in the space. The contribution of each point to a metric space’s global magnitude, which is encoded by the weighting vector , captures much of the underlying geometry of the original metric space. Surprisingly, when the metric space is Euclidean, the weighting vector also serves as an effective tool for boundary detection. This allows the weighting vector to serve as the foundation of novel algorithms for classic machine learning tasks such as classiﬁcation, outlier detection and active learning. We demonstrate, using experiments and comparisons on classic benchmark datasets, the promise of the proposed magnitude and weighting vector-based approaches