Miracle-dz/UniFAR-FTUs huggingface dataset:
The contribution of galenics to patients’ sensory perception of nasal sprays after nasal surgery – data from a prospective randomized, controlled, double-blind, cross-over, multi-centre study

Introduction:Postoperative care after nasal surgery is commonly achieved with nasal sprays. The current study compared two decongesting, wound healing nasal sprays in patients after nasal surgery in order to investigate their sensoric perception. One of the sprays presented a new galenic formulation (nasic® neo, Cassella-med GmbH & Co. KG). Methods:Using a cross-over design, patients who had undergone nasal surgery applied two different nasal sprays during two treatment periods of 4 days each, interrupted by 3 days wash out period. Sensoric perception of the nasal sprays was assessed with the nasal-spray-sensoric-scale. Throughout the study, nasal obstruction was evaluated by patients, and physical examinations, measurements of vital parameters and rhinoscopic examinations were carried out by investigators. Adverse events were documented during the entire study, and following treatment, patients judged the overall preference, efficacy and tolerability of both products.Results:Overall, no significant differences in sum scores of the assessments of the nasal-spray-sensoric-scale were observed between treatments. Significant periodic effect observed during the cross-over study limited the overall analysis. Nevertheless, it could be shown that significantly more patients preferred the new galenics nasal spray compared to the comparator spray (57.1% vs. 34.7%; p=0.031). Further, 10% more patients rated the efficacy of new galenics as ‘good’ to ‘very good’ compared to the comparator. Importantly, a subgroup population of patients with more pronounced signs of inflammation present at screening evaluated the sensoric perception of new galenics significantly better (p=0.033) compared to the comparator. Within this subgroup, no periodic effect was observed. The application of both nasal sprays was shown to be safe and well-tolerated.Conclusion:The current study showed that the overall sensoric perception of both nasal sprays was evaluated comparably well in patients after nasal surgery and that overall, the application of the new galenics nasal spray was preferred by significantly more patients compared to the comparator nasal spray. Patients with marked nasal abnormalities may have a greater benefit from the contribution of galenics as significant differences in the sensoric evaluation by the nasal-spray-sensoric-scale in favour of the new galenics product were shown for this subgroup.Trial registration: The current study was registered in the EU Clinical Trials Register with the EudraCT No: 2019-004936-52.
Cognitive remediation group therapy compared to mutual aid group therapy for people aging with HIV-associated neurocognitive disorder: randomized, controlled trial

ABSTRACT Cognitive impairment is an important comorbidity for people aging with HIV, and group therapy may ameliorate the associated anxiety and stress. Combination psychosocial interventions may have better outcomes than single technique approaches. A pilot, parallel design, two-arm trial randomized people aging with HIV-Associated Neurocognitive Disorder (HAND) to Cognitive Remediation Group Therapy (Experimental; combination of brain training activities and mindfulness-based stress reduction) or Mutual Aid Group Therapy (Control). Outcomes were feasibility, acceptability, fidelity, and exploratory measures of anxiety, stress, coping, and use of mindfulness and brain training activities. Among 40 contacted participants, 15 replied, 12 recruited, and 10 completed. Assessors confirmed intervention delivery with satisfactory fidelity. The novel arm had statistically significant improvements in stress and mindfulness use compared to control, and brain training and mindfulness use sustained at 3-month follow-up. Requiring a HAND diagnosis made recruitment challenging. Further research should broaden eligibility to people aging with HIV and cognitive challenges.
Numerical solutions to linear transfer problems of polarized radiation. I. Algebraic formulation and stationary iterative methods

Context. The numerical modeling of the generation and transfer of polarized radiation is a key task in solar and stellar physics research and has led to a relevant class of discrete problems that can be reframed as linear systems. In order to solve such problems, it is common to rely on efficient stationary iterative methods. However, the convergence properties of these methods are problem-dependent, and a rigorous investigation of their convergence conditions, when applied to transfer problems of polarized radiation, is still lacking. Aims. After summarizing the most widely employed iterative methods used in the numerical transfer of polarized radiation, this article aims to clarify how the convergence of these methods depends on different design elements, such as the choice of the formal solver, the discretization of the problem, or the use of damping factors. The main goal is to highlight advantages and disadvantages of the different iterative methods in terms of stability and rate of convergence. Methods. We first introduce an algebraic formulation of the radiative transfer problem. This formulation allows us to explicitly assemble the iteration matrices arising from different stationary iterative methods, compute their spectral radii and derive their convergence rates, and test the impact of different discretization settings, problem parameters, and damping factors. Conclusions. The general methodology used in this article, based on a fully algebraic formulation of linear transfer problems of polarized radiation, provides useful estimates of the convergence rates of various iterative schemes. Additionally, it can lead to novel solution approaches as well as analyses for a wider range of settings, including the unpolarized case.
A Preliminary Study Investigating the Effects of Yoga Therapy on Impulsivity in Children Diagnosed with a Psychiatric Condition

Abstract This research examined whether 14 male patients (10–13 years old, with a range of psychiatric conditions) at a residential treatment facility show decreased impulsivity due to weekly yoga sessions in addition to their traditional therapy. For 5 weeks, the number of impulsive behaviours were recorded for eight hours preceding and eight hours following an early afternoon yoga session (short-term) and for 24 waking hours before and 24 waking hours after the session (long-term). Analyses revealed statistically significant short-term and long-term effects of yoga on impulsive behaviours, suggesting that yoga provides a tool to help children successfully reunify with their families.
Impact of annealing on performance of X-ray mirror coatings for Athena

As part of the manufacturing process of mirror modules for the Athena X-ray telescope, Silicon Pore Optics plates are assembled into mirror module stacks. The plates that form each stack are held together by direct bonding, relying on van der Waals forces and covalent bonds for adhesion. One way to increase the strength of the covalent bonds is through annealing of the mirror stacks. It is of critical importance to the mission to ensure compatibility between the reflective coating and any post-coating processing of the plates. We present our findings of the impact of annealing on the X-ray re ectance of coated mirrors relevant for the Athena mission. These are Ir single layers, as well as Ir/B4C, Ir/SiC, and Ir/C bilayers. We investigate the effect on the performance of the coatings after annealing at atmospheric pressure and at a low vacuum using X-ray reflectometry. B4C is found to suffer degradation from annealing under atmospheric conditions but not when annealed in vacuum. All other materials investigated are robust to atmospheric annealing.
Drop out from mental health treatment in the Saudi national mental health survey

Abstract Objectives To evaluate the patterns and potential risk factors associated with mental health treatment dropout in the Saudi National Mental Health Survey (SNMHS). Methods The SNMHS is a face-to-face community-based epidemiological survey in a nationally representative household sample of respondents aged 15–65 in the Kingdom of Saudi Arabia (KSA) (n = 4,004). The sample was limited to those who had received any type of mental health treatment during the past year (n = 168). The distribution of service use and the number of visits were examined. Predictors of treatment dropout were analyzed using logistic regression models. Results Treatment drop out rate was very high overall (42.1%), with dropout occurring early (after 2 visits) in the majority of cases. Participants who were previously married or were diagnosed with a 12-month substance use disorder were significantly more likely than other participants to drop out. Those receiving care from more than three types of providers were significantly less likely than others to terminate treatment prematurely. Conclusions The rate of premature termination of treatment was high and positively associated with previously married status and substance use and inversely related to the number of different providers and number of visits.
Public spaces as transformative creative wellness spaces: an evaluation of Musical Intervention

ABSTRACT Musical Intervention (MI) is a public space that supports individuals who seek opportunities for creativity and connection with the broader community. This study sought to evaluate and understand MI through surveys, qualitative interviews, and ethnographic observations. Data revealed that participants 1) described the space as a socially integrated community and a nonclinical therapeutic and sober environment; and 2) described their personal experience using MI. Public spaces like MI can provide integrative and transformative sober spaces for marginalized individuals to spend time outside of clinical settings as well as therapeutic opportunities through creative expression, supplementing the efforts of service providers.
Building Self-reliance: A Framework to Evaluate Smallholder Coffee Farmers’ Pursuit of Commercialization

his study examines the application of a self-reliance framework for practitioners and evaluators to better understand the capacities and intrinsic factors impacting smallholder coffee farmers’ commercialization behaviors. We surveyed 40 smallholder coffee producers in Peru using a quantitative instrument. Data were analyzed to determine if statistical relationships exist between farmers’ self-reliance (measured via knowledge and skills, attitudes, and aspirations) and their commercialization behaviors. Findings indicate the self-reliance framework effectively illustrates relationships between farmers’ aspirations, knowledge and skills and their commercialization behaviors, while future, additional studies are needed to better measure and understand the role of commercialization-related attitudes. Practitioners can leverage the study’s findings by using a self-reliance framework to infer farmers’ likeliness to pursue sustainable commercialization practices and align their trainings and design interventions based on evaluation findings. The conceptual self-reliance framework is the first of its kind applied for smallholder coffee commercialization. The findings demonstrate that self-reliance concepts employed recently in other contexts may potentially be used similarly by extension and development facilitators. Keywords: coffee, commercialization, external facilitator, Peru, self-reliance, smallholder
Gaussian relevance vector MapReduce-based annealed Glowworm optimization for big medical data scheduling

Abstract Various big-data analytics tools and techniques have been developed for handling massive amounts of data in the healthcare sector. However, scheduling is a significant problem to be solved in smart healthcare applications to provide better quality healthcare services and improve the efficiency of related processes when considering large medical files. For this purpose, a new hybrid model called Gaussian Relevance Vector MapReduce-based Annealed Glowworm Optimization Scheduling (GRVM-AGS) was designed to improve the balancing of large medical data files between different physicians with higher scheduling efficiency and minimal time. First, a GRVM model was developed for the predictive analysis of input medical data. This model reduces the storage complexity of large medical data analysis by means of eliminating unwanted patient information and predicts the disease class with help of a Gaussian kernel function. Afterwards, GRVM performs AGS to schedule the efficient workloads among multiple datacenters based on the luciferin value in the smart healthcare environment with reduced scheduling time. Through computational experiments, we demonstrate that GRVM-AGS increases the scheduling efficiency and reduces the scheduling time of large medical data analysis compared to state-of-the-art approaches.
Equatorial Plasma Drifts During the Magnetic Storm on November 7–11, 2004: Identifications of the Roles of Penetration and Disturbance Dynamo Electric Fields With Multi‐Instrumental Measurements

Penetration electric fields and disturbance dynamo electric fields are the two major disturbance electric fields in the equatorial ionosphere during geomagnetic storms. In this study, we analyze equatorial ion drifts measured by radar and satellites during the geomagnetic storm on November 7–11, 2004. The magnetic storm had two main phases, with minimum Dst values of −373 and −289 nT, respectively. The equatorial vertical ion drifts in the dusk‐evening sector were continuously enhanced in the upward direction for 13 h on November 7–8, including 7 h of the first main phase and 6 h of the early stage of the recovery phase. On November 10, the equatorial vertical ion drifts were continuously enhanced in the upward direction for ∼10 h, including ∼9 h of the second main phase and ∼1.5 h of the early stage of the recovery phase. Enhanced thermospheric nitric oxide 5.3 μm emission and westward disturbance winds were measured in the equatorial region during the two main phases of the magnetic storm, indicating occurrence of disturbance dynamo electric fields. The observations show that penetration electric fields are the dominant electric fields in the equatorial ionosphere for 13 and 10 h with continuous southward IMF even if disturbance winds already occur. Very large westward ion drifts are generated in the dusk‐evening equatorial region during the magnetic storm. It is suggested that the westward drifts are caused by penetration of electric fields associated with subauroral polarization streams.
Effect of the Short-Term Incorporation of Different Proportions of Ensiled Artichoke By-Product on Milk Parameters and Health Status of Dairy Goats

The use of local agricultural by-products for animal feed is an alternative that reduces livestock production costs and allows food production of greater environmental sustainability. The aim of this experiment was to study the effect of the inclusion in the dairy goat ration of artichoke by-product silage (ABS) at three levels (25%, 40% and 60%, on a dry matter basis) on the milk yield, composition and quality, and on the metabolic profile of dairy goats. Thirty-six Murciano-Granadina dairy goats in mid-lactation were divided into four groups with homogeneous characteristics. Each group was assigned a diet: a control treatment (C) that consisted of a conventional diet of alfalfa hay and concentrate, and three other treatments that included 25, 40 and 60% ABS: ABS25, ABS40 and ABS60. Small differences were observed in the milk yield and quality and the health status of the animals. Only ABS60 presented a slightly lower milk yield (−20% compared to control group), without relevant differences in the milk composition and mineral profile. Regarding the lipid profile, ABS40 was the treatment with the best milk quality, due to a higher content of polyunsaturated fatty acids (4.37%) and lower atherogenicity (1.90) and thrombogenicity indices (3.05), without differences from C. It was concluded that the maximum inclusion level of ABS in dairy goats’ diet should be equal to 40%.
Effect of Monetary Policy on the Nigerian Stock Market: A Smooth Transition Autoregressive Approach

This paper examines the nonlinear effect of monetary policy decisions on the performance of the Nigerian Stock Exchange market, by employing the Smooth Transition Autoregressive (STAR) model on monthly data from 2013 M4 to 2019 M12 for All Share Index and monetary policy instrument. This study considers the two regimes characterizing the stock market, which are the lower regime (the bear market) and the upper regime (the bull market). The results show evidence of nonlinear effect of monetary policy on the stock exchange market. Monetary policy rate, money supply, lagged monetary policy rate and lagged treasury bill rate are found to have significant positive effects on the stock exchange market in the lower regime while current treasury bill rate shows a negative effect. In the upper regime, money supply and lagged treasury bill rate have significant negative effect on the stock market. The current treasury bill rate is found to have a positive effect on the stock exchange market. It is recommended that the Central Bank of Nigeria should maintain a stable money supply growth that is consistent with increased activities in the Nigerian stock market.
The Intersection Between Sex and Race in Understanding Substance Co-Use Patterns in Adolescents From the Fragile Families Study

The current study examined the prevalence of alcohol, cigarette, and cannabis co-use among a longitudinal cohort of youth predominately born to single-parent families. Data were drawn from wave six of the Fragile Families and Child Wellbeing Study (N = 2976; M age = 15.6; 49% female; 53% non-Hispanic Black, 27% Hispanic, 20% White). Adolescents’ reports of their past 30-day use of alcohol, cigarettes, and cannabis were used to construct eight mutually exclusive use groups. Multinomial logistic regressions adjusting for sociodemographic factors revealed that Black adolescents were at lower relative risk of using Alcohol Only compared to White adolescents. Black males were at greater relative risk of using Cannabis Only than both White males and Black females. Finally, Hispanic males were at a marginally increased relative risk of co-using Alcohol and Cannabis compared to White males. Prevention efforts targeting Black and Hispanic males’ use of cannabis (both alone and in combination with alcohol) may be beneficial.
Impacts of the National Forest Rehabilitation Plan and Human-Induced Environmental Changes on the Carbon and Nitrogen Balances of the South Korean Forests

Humans have affected the carbon (C) and nitrogen (N) cycles in forests; however, the quantification of the responses of forest C and N balances to human activities is limited. In this study, we have quantified the impacts of the long-term national forest rehabilitation plan and the contribution of the increase in air temperature, CO2 concentration, and N deposition on the C and N balances of the South Korean forests during 1973–2020 by using a biogeochemical model. During the simulation period, the C balance increased from 0.2 to 4.3 Mg C ha−1 year−1, and the N balance increased from 0.2 to 17.4 kg N ha−1 year−1. This resulted in the storage of 825 Tg C and 3.04 Tg N by the whole South Korean forests after the national forest rehabilitation plan. The increase in air temperature, CO2 concentration, and N deposition contributed −11.5, 17.4, and 177 Tg C to the stored C stock, respectively, and −25.4, 8.90, and 1807 Mg N to the stored N stock, respectively. This study provides references for future forest rehabilitation efforts and broadens our knowledge on the impacts of human-induced environmental changes on the C and N balances of forests.
Clinical profile of cutaneous manifestations of connective tissue diseases in North-East India

Background: Connective tissue diseases (CTDs) are a heterogeneous group of autoimmune disorders having overlapping clinical features. Skin is often involved and it may be the earliest sign of the disease. This study highlighted the various cutaneous manifestations of common CTDs.Methods: A hospital-based cross-sectional study was carried out for a period of two years in 83 patients with CTDs in dermatology OPD, RIMS, Imphal. Detailed history taking, examination and relevant serological tests were performed.Results: The mean age was 39.78±17.29 years with female to male ratio of 4.5:1. Majority of the patients had lupus erythematosus (LE) (N=45) followed by systemic sclerosis (SSc) (N=25), rheumatoid arthritis (RA) (N=6), mixed connective tissue disease (MCTD) (N=4) and morphea (N=3). The most common presentation was raised skin lesions (45.8%) followed by Raynaud’s phenomenon (36.1%), photosensitivity (27.7%), skin tightness (26.5%) and joint pain (19.3%). Among LE patients, chronic cutaneous lupus erythematosus (CCLE) was the commonest variant and localised discoid lupus erythematosus (DLE) (22.9%) was the commonest presentation followed by malar rash and annular subacute lupus erythematosus (SCLE). Skin induration, microstomia and sclerodactyly were seen in most patients of SSc. Antinuclear antibodies were positive in 89.1% of patients. Anti-dsDNA and anti-Sm antibodies were positive in 62.2% and 33.3% of LE patients, anti-Scl 70 antibody was positive in 68% of SSc patients.Conclusions: CTDs are rare but potentially life-threatening. Proper understanding of the spectrum of cutaneous manifestations of CTDs is therefore necessary for early diagnosis and efficient management.
Eminence-focused talent development in drum and bugle corps

ABSTRACT We analyze eminence-focused talent development in drum and bugle corps. After defining and characterizing the world-class drum and bugle corps activity as a collective aesthetic sport in which eminent group performance levels are achieved, we introduce a framework for investigating eminence-focused collective talent development in drum corps from a systemic perspective based on the actiotope model of giftedness. We then illustrate the framework’s application to eminence-focused world-class drum and bugle corps with examples taken from the research literatures of marching arts, talent development, and musicology. We also note examples of masterly drum-corps performances and the framework’s utility for future scientific investigation.
Analysing Clariﬁcation in Asynchronous Information-Seeking Conversations

This research analyses human-generated clariﬁcation questions to provide insights into how they are used to disam-biguate and provide a better understanding of information needs. A set of clariﬁcation questions is extracted from posts on the Stack Exchange platform. Novel taxonomy is deﬁned for the annotation of the questions and their responses. We investigate the clariﬁcation questions in terms of whether they add any information to the post (the initial question posted by the asker) and the accepted answer, which is the answer chosen by the asker. After identifying which clariﬁcation questions are more useful, we investigate the characteristics of these questions in terms of their types and patterns. Non-useful clariﬁcation questions are identiﬁed, and their patterns are compared with useful clar-iﬁcations.