Miracle-dz/UniFAR-FTUs huggingface dataset:
Enzymatic Redox Properties and Cytotoxicity of Irreversible Nitroaromatic Thioredoxin Reductase Inhibitors in Mammalian Cells

NADPH:thioredoxin reductase (TrxR) is considered a potential target for anticancer agents. Several nitroheterocyclic sulfones, such as Stattic and Tri-1, irreversibly inhibit TrxR, which presumably accounts for their antitumor activity. However, it is necessary to distinguish the roles of enzymatic redox cycling, an inherent property of nitroaromatics (ArNO2), and the inhibition of TrxR in their cytotoxicity. In this study, we calculated the previously unavailable values of single-electron reduction potentials of known inhibitors of TrxR (Stattic, Tri-1, and 1-chloro-2,4-dinitrobenzene (CDNB)) and inhibitors identified (nitrofuran NSC697923 and nitrobenzene BTB06584). These calculations were according to the rates of their enzymatic single-electron reduction (PMID: 34098820). This enabled us to compare their cytotoxicity with that of model redox cycling ArNO2. In MH22a and HCT-116 cells, Tri-1, Stattic, CDNB, and NSC697023 possessed at least 10-fold greater cytotoxicity than can be expected from their redox cycling activity. This may be related to TrxR inhibition. The absence of enhanced cytotoxicity in BTB06548 may be attributed to its instability. Another known inhibitor of TrxR, tetryl, also did not possess enhanced cytotoxicity, probably because of its detoxification by DT-diaphorase (NQO1). Apart from the reactions with NQO1, the additional mechanisms influencing the cytotoxicity of the examined inhibitors of TrxR are their reactions with cytochromes P-450. Furthermore, some inhibitors, such as Stattic and NSC697923, may also inhibit glutathione reductase. We suggest that these data may be instrumental in the search for TrxR inhibitors with enhanced cytotoxic/anticancer activity.
Environmental and financial optimization: Hybrid generation (wind-PV) with battery energy storage

This study proposes a multiobjective optimization to identify the best combinations for renewable hybrid generation (wind-PV) with the use of battery storage systems, at a residential level for the Brazilian scenario. The objectives of this optimization are to maximize the Net Present Value (NPV) and minimize the emission of CO 2 eq - GHG (CO 2 equiv/KWh) - Carbon footprint, using the Response Surface Methodology (RSM) to model the objective functions. The Normal Boundary Intersection (NBI) method was used to generate the Pareto frontier with the optimal points and the LCOE variable was used to select the best optimal solution on the frontier. The method will consider one of the possibilities of the Brazilian tariff model, the white tariff, which is an hourly billing modality. First, the regression models generated for each selected city were significant by the ANOVA p-value test, being less than 0.05. In addition, the R ² and adjusted R ² values were also expressive, with results above 80%, indicating a high degree of explainability of the modeled process.
Effectiveness of internet-delivered cognitive behavioral therapy for insomnia: a systematic review and meta-analysis

ABSTRACT This systematic review and meta-analysis aimed to assess the effectiveness of internet-delivered cognitive behavioral therapy for insomnia (ICBT-I) in the short and long term. We searched five electronic databases for studies published from June 2000 to May 2022. Our analysis included 27 studies with 8,728 participants, of which 4394 were in the experimental group and 4334 were in the control group. ICBT-I significantly improved the sleep scores of the experimental group by reducing the intensity of insomnia (ISI) (−4.32) in the post-intervention (I2 = 94%) (95% CI −6.15 to −2.48, p < 0.0001, g = 0.760) and follow-up phases (−2.92) (I2 = 95%) (95% CI −4.87 to −0.97, p < 0.0003, g = 0.622). This therapy also effectively improves short-term and long-term insomnia symptoms, including sleep onset latency, wake after sleep onset, night awakenings, sleep efficiency, and total sleep time. That holds the potential for extensive utilization across diverse populations suffering from insomnia, surpassing the limitations associated with conventional in-person therapeutic methods.
What Hurts Most? A Comparison of College Students' Perceptions of Cyber and Traditional Victimization

Although the research literature has demonstrated that cyber victimization is associated with a variety of negative psychological and social consequences, the support for the uniqueness of cyber bullying as distinct from traditional bullying is mixed. The current study conducted a quasi-experimental comparison of college students' perceptions of the anticipated hurt and reputational ramifications of cyber and traditional victimization. Generally, students rated the negative implications of cyber bullying as similar to those of traditional bullying. As exceptions, participants perceived greater hurt associated with face-to-face "flaming" behavior compared to experiencing the same situation online. Regardless of modality, "flaming" victimization was considered to be the least harmful emotionally and to the reputation, while "outing" was considered to be the most harmful. Finally, personal experiences with traditional victimization and poorer self-esteem were associated with perceptions of more emotional harm, or perceived hurt, associated with traditional victimization. However, among those with personal histories of traditional bullying, men were more likely than women to anticipate being hurt by cyber bullying. In summary, the type of victimization may be more important than the modality (online versus face-to-face).
The Quarterly Journal of Experimental Psychology Immediate Inferences from Quantified Assertions

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Understanding the real value of fractions and decimals

Understanding fractions and decimals is difficult because whole numbers are the most frequently and earliest experienced type of number, and learners must avoid conceptualizing fractions and decimals in terms of their whole-number components (the “whole-number bias”). We explored the understanding of fractions, decimals, two-digit integers, and money in adults and 10-year-olds using two number line tasks: marking the line to indicate the target number, and estimating the numerical value of a mark on the line. Results were very similar for decimals, integers, and money in both tasks for both groups, demonstrating that the linear representation previously shown for integers is also evident for decimals already by the age of 10. Fractions seem to be “task dependent” so that when asked to place a fractional value on a line, both adults and children displayed a linear representation, while this pattern did not occur in the reverse task.
Nonclassical Optical Bistability and Resonance-Locked Regime of Photon-Pair Sources Using Silicon Microring Resonator

This study presents $e\phantom{\rule{0}{0ex}}x\phantom{\rule{0}{0ex}}p\phantom{\rule{0}{0ex}}e\phantom{\rule{0}{0ex}}r\phantom{\rule{0}{0ex}}i\phantom{\rule{0}{0ex}}m\phantom{\rule{0}{0ex}}e\phantom{\rule{0}{0ex}}n\phantom{\rule{0}{0ex}}t\phantom{\rule{0}{0ex}}a\phantom{\rule{0}{0ex}}l$ evidence of nonclassical optical bistability, in the context of photon-pair generation via spontaneous four-wave mixing in a silicon microring resonator. The hysteresis results greatly benefit on-chip quantum optics, to build a bridge between classical and potential nonclassical applications of optical bistability in microcavities. This work also improves traditional resonance-locked strategies by balancing power-induced heating and active cooling; since no precise pump tuning is required, the proposed resonance-locked regime can be more widely applied in fixed-wavelength optical communication systems.
Influence of positive end‐expiratory pressure on cardiac performance in premature infants: A Doppler‐echocardiographic study

Because determining cardiac output is difficult in premature infants, little is known about the hemodynamic effects of PEEP in this age group. We used pulsed-wave Doppler echocardiography to assess the hemodynamic effects of PEEP increments in ten premature infants with respiratory distress syndrome. At a PEEP of 4 cm H2O, the systemic and pulmonary blood flow and the right (SVRV) and left (SVLV) ventricular stroke volume decreased slightly, while the systemic vascular resistance (Rs) increased slightly. At a PEEP of 8 cm H2O, cardiac performance was impaired significantly, with a profound decrease of the systemic and pulmonary blood flow, SVRV and SVLV and a reflectory increase of the Rs. Surprisingly, the heart rate and mean arterial BP remained constant. The effective left ventricular afterload, which takes into account the changing intrathoracic pressure, increased slightly with increasing PEEP.
Cervical Cancer Awareness and Attitude Towards Cervical Cancer Screening and Human Papillomavirus Vaccines Among Urban Women of Karachi, Pakistan

Cervical cancer is the second most common cancer among women under 50 years of age in Pakistan. The current study was designed to assess the level of awareness through educational outreach presentations about cervical cancer, Papanicolaou (Pap) smear test, and human papillomavirus (HPV) vaccination in Karachi, Pakistan. Women from different urban hospitals were enrolled. Participants participated in a 45-minute presentation on cervical cancer awareness led by student pharmacists from Nazeer Hussain University, Karachi. A pre-and post-test was administered to assess the impact of the intervention. Descriptive statistics were used to summarize the findings, and a t-test was used for matched comparison, and a p-value <0.05 for statistical significance. A total of 150 women participated in the study. The study found that Pakistani women living in urban settings were less knowledgeable about the causes of cervical cancer and prevention. After the presentation, we observed a 45% increase in knowledge, and 31% of participants said they would obtain a Pap smear test in the next six months. Supervised pharmacy student-led presentations on cervical cancer educational awareness that significantly impacted women participants. Pharmacists can play a key role in reducing cervical cancer deaths through increased awareness, education, prevention, and immunization.
The First Report on Sero-Prevalence of Toxoplasma gondii in Working Horses and Donkeys in the Sudan

A serological survey of Toxoplasma gondii was conducted using LAT (Latex Agglutination Test) on 205 sera collected from working horses and donkeys in Khartoum State, Sudan. The overall sero-prevalence of the investigated equines was 32.7%. Antibodies to T. gondii were found in 38% of 100 horses and 27.6% of 105 donkeys. The titers were 1:2 (4 heads), 1:4 (11 heads), 1:8 (13 heads), 1:16 (17 heads), 1:32 (5 heads), 1:64 (10 donkeys) and 1:128 (7 donkeys). Neither the area nor animal species showed significant differences between the investigated groups. However, age was reported to show significant (P < 0.05) effect on equine toxoplasmosis in the Sudan. This is the first report on equine toxoplasmosis in the Sudan.
Study on the mechanism of Lu’an GuaPian tea in treating heart failure based on network pharmacology and molecular docking

ABSTRACT Objective The study was to investigate the possible mechanism of Lu'an GuaPian tea in treating heart failure (HF) via network pharmacology and molecular docking. Method The target of Lu'an GuaPian tea were screened. The GeneCards, NCBI, and DisGeNET databases were searched for HF targets. The GO and KEGG pathway analysis were used to obtain the targets and pathways. Molecular docking was used to verify the most likely targets and flavonoids. Results The Venn diagram revealed that AKT1, TNF, SRC, EGFR, ESR1, PTGS2, MMP9, and KDR were the top 8 target genes. GO and KEGG analysis suggested that Lu'an GuaPian tea could treat HF through PI3K-Akt pathway. Molecular docking predicted that compounds 1 and 7 have the highest binding affinity. Conclusion Lu'an GuaPian tea can be used to treat HF via PI3K-Akt signaling pathway, and the compound 1 and 7 were the most active lead compounds for regulating PI3K.
Machine learning in predicting T-score in the Oxford classification system of IgA nephropathy

Background Immunoglobulin A nephropathy (IgAN) is one of the leading causes of end-stage kidney disease (ESKD). Many studies have shown the significance of pathological manifestations in predicting the outcome of patients with IgAN, especially T-score of Oxford classification. Evaluating prognosis may be hampered in patients without renal biopsy. Methods A baseline dataset of 690 patients with IgAN and an independent follow-up dataset of 1,168 patients were used as training and testing sets to develop the pathology T-score prediction (T pre) model based on the stacking algorithm, respectively. The 5-year ESKD prediction models using clinical variables (base model), clinical variables and real pathological T-score (base model plus T bio), and clinical variables and T pre (base model plus T pre) were developed separately in 1,168 patients with regular follow-up to evaluate whether T pre could assist in predicting ESKD. In addition, an external validation set consisting of 355 patients was used to evaluate the performance of the 5-year ESKD prediction model using T pre. Results The features selected by AUCRF for the T pre model included age, systolic arterial pressure, diastolic arterial pressure, proteinuria, eGFR, serum IgA, and uric acid. The AUC of the T pre was 0.82 (95% CI: 0.80–0.85) in an independent testing set. For the 5-year ESKD prediction model, the AUC of the base model was 0.86 (95% CI: 0.75–0.97). When the T bio was added to the base model, there was an increase in AUC [from 0.86 (95% CI: 0.75–0.97) to 0.92 (95% CI: 0.85–0.98); P = 0.03]. There was no difference in AUC between the base model plus T pre and the base model plus T bio [0.90 (95% CI: 0.82–0.99) vs. 0.92 (95% CI: 0.85–0.98), P = 0.52]. The AUC of the 5-year ESKD prediction model using T pre was 0.93 (95% CI: 0.87–0.99) in the external validation set. Conclusion A pathology T-score prediction (T pre) model using routine clinical characteristics was constructed, which could predict the pathological severity and assist clinicians to predict the prognosis of IgAN patients lacking kidney pathology scores.
Stock Market Reaction to Accounting Information of Listed Pharmaceutical Companies in Nigeria

The aim of this study was to investigate the effect of accounting information on stock market reaction of quoted pharmaceutical companies in Nigeria by determining whether there is a significant relationship between accounting information and stock market reaction using 2009 to 2014 secondary data collected from the Nigeria Stock Exchange office in Port Harcourt, Rivers State, Nigeria. An ex post facto research design was appropriately adopted to address the objective of the study. Because of the research design adopted, a multiple regression analysis was employed to test the hypothesis raised in the study. The independent variable, which is accounting information, is measured as earnings per share (EPS) and book value per share (BVS), while the dependent variable, which is stock market reaction, is measured as stock price. The results obtained suggest that there is no statistically significant relationship between accounting information and stock market reaction; drawing on this finding, we concluded that accounting information has no significant effect on stock market reaction. Based on this finding, we recommend that sound and specific guidelines on accounting information should be issued by the Financial Reporting Council of Nigeria (FRCN) and the Security and Exchange Commission (SEC) so as to increase the relevance of accounting information of quoted companies.
Factors Associated with Foodborne Pathogens among Food Handlers: A Case Study of Thika, Kiambu County, Kenya

Increasing risks of infections with foodborne pathogens may occur as a result of poor food handling practices. The present cross-sectional study employed a mixed-methods approach to determine the factors associated with foodborne pathogens among food handlers working in the food establishments in Thika, Kiambu County, Kenya. Random sampling was used to enroll respondents in the survey. A single stool specimen was collected from each study participant. Laboratory analysis of the specimen was done to test the selected foodborne pathogens. Overall, 44 out of the 285 food handlers who took part in the study had at least one food-transmitted pathogen, putting the prevalence of foodborne infections among the food handlers at 15.4% (95% confidence interval (CI) 11.7%–20.1%). The findings from multivariate logistic regression indicated the following protective factors for foodborne pathogens among the studied food handlers: being female (adjusted odds ratio (AOR) 0.098 (95% CI 0.0304–0.315, p < 0.001 )); having a valid medical examination certificate (AOR 0.141 (95% CI 0.141–1. 0.439, p = 0.001 )); not boiling or treating water before serving the water to customers was a risk factor for having infections with foodborne pathogens (AOR 3.043 (95% CI 1.2225–7.577, p = 0.017 )). The presence of foodborne pathogens among the food handlers in the study area potentially highlights the need to address the spread and transmission of foodborne infections in the study area. There is a need to institute appropriate control measures, including regular screening of food handlers for foodborne illnesses in addition to training them on safe food handling practices, hand hygiene practices, and regular monitoring of the food handling practices.
Forest Biomass Mapping Using Continuous InSAR and Discrete Waveform Lidar Measurements: A TanDEM-X/GEDI Test Study

This article addresses the implementation of an above ground biomass (AGB) estimation scheme relying on the height-to-biomass allometry at stand level in the context of the synergistic use of continuous TanDEM-X (bistatic) interferometric synthetic aperture radar acquisitions and spatial discrete GEDI waveform lidar measurements. The estimation of forest height and horizontal forest structure from TanDEM-X data in the absence of a digital terrain model (DTM) is discussed. The possibility of estimating (top) canopy height variations independent of topographic height variations is discussed using wavelet-based scale analysis. This understanding is then exploited to define a structure index expressing the (top) canopy-only height variations in the absence of a DTM. The potential of using the derived structure information to account for the spatial variability of height-to-biomass allometry derived from the GEDI measurements is addressed. The performance of the conventional height-to-biomass allometry and the one achieved by the locally adapted implementation are compared against reference lidar measurements and discussed. The analysis is carried out using GEDI and TanDEM-X interferometric measurements and validated by using LVIS lidar measurements over the Lopé National Park, a diverse tropical forest test site in Gabon.
PROFITABILITY AS A MEDIATION VARIABLE OF LIQUIDITY, SOLVENCY AND THE INFLUENCE OF ACTIVITIES ON COMPANY VALUE (Studies on the Oil and Gas Sub-Sector Listed on the Indonesia Stock Exchange in 2017-2021)

This study aims to determine the effect of liquidity, solvency, and activity mediated by profitability on firm value. The object of this study is the sub-sector of oil and gas companies listed on the Indonesia Stock Exchange with a study population of 8 companies. Selection of the sample using the saturated sample method. The research design is a causality study with data analysis methods using panel data regression analysis. The results of the research show that the variables of liquidity, solvency and activity do not directly affect firm value. Liquidity and solvency variables mediated by profitability have a positive effect on firm value. KEYWORDS: liquidity, solvency, activity, profitability, firm value.
Channel network hydrology

Network hydrology and geomorphology, Mike Kirkby extraction of channel networks and topographic parameters from digital elevation data, Larry Band the geomorphological unit hydrograph, I. Rodriguez-Iturbe flow resistance through the channel network, James Bathurst hydrological response of channel networks, Keith Beven and Eric Wood solute transport in channel, Peter Young and Steve Wallis the stream head, Bill Dietrich and Tom Dunne sediment transport into and through the network, Keith Richards the long term interaction of sediment and water through networks and side slopes, Mike Kirkby models of channel networks - theory and predictive uncertainty, Keith Beven.
Nonlinear Jordan higher derivations of incidence algebras

Abstract Let R be a 2-torsion free commutative ring with unity and X be a locally finite preordered set. We prove in this paper that every nonlinear Jordan higher derivation on the incidence algebra I(X,R) is an additive higher derivation, provided that all connected components of X are nontrivial.
Do epistemically more sophisticated students always learn better than epistemically less sophisticated students in a constructivist learning context?

Abstract Previous studies suggested that epistemically more sophisticated students learned better in a constructivist learning context than epistemically less sophisticated students did. This study further examined if students with higher prior epistemic beliefs (EB High) had better learning gains than students with lower prior epistemic beliefs (EB Low) in a different constructivist learning context—Knowledge Building. We found that EB High and EB Low students did not differ in learning gains in Knowledge Building. We also examined how EB High and EB Low students engaged in epistemic practices on Knowledge Forum. Through discourse analysis, we found that although EB High students engaged in more sophisticated epistemic practices than EB Low students did, they both improved their epistemic practices; as time unfolded, the gaps between their epistemic practices narrowed down. This study has important implications for how to help students with different epistemic sophistication benefit from a constructivist learning context.