Miracle-dz/UniFAR-FTUs huggingface dataset:
Int. J. Biosci

Curcumin is a phenolic compound extracted from the rhizome of turmeric (Curcuma longa L.). Although declared as safe for human consumption, curcumin has been found to be embryotoxic in some organisms indicating its potential as a teratogen. In this study, the teratogenic effect of maternal curcumin exposure in mouse fetuses was evaluated. Three experimental groups of pregnant mice were treated with 1.05, 1.52, and 2.0 mg/g body weight/day 95% curcumin, respectively, from gestation day (GD) 6 to 15. A fourth group without curcumin exposure served as a control. At GD18, the mice were sacrificed and the total number of implanted embryos including resorbed, dead, and live fetuses were counted for litter analysis. Extracted fetuses were also analyzed for gross morphological anomalies and subsequently have undergone alizarin staining for the visualization of skeletal malformations. Results showed an increased resorption rate in the 2.0 mg/g treatment (p<0.001). There is also a reduction of fetal weight (p<0.001) and crown-rump length (p<0.001) in a dosedependent manner. Gross morphological analysis shows cranio-facial malformations such as flattened nose bridge (p<0.05) and micrognathia (p<0.05) in 2.0 mg/g treatment. Skeletal malformations such as large anterior fontanelle (p<0.001), misaligned ossification centers in the sternum (p<0.001), and delayed ossification in the forepaws, hind paws, and caudal vertebrae (p<0.001) were also observed at 2.0 mg/g treatment. Meanwhile, the presence of supernumerary ribs is not statistically different in the four groups. The results indicate that curcumin is teratogenic in mouse fetuses due to observed gross morphological anomalies and skeletal malformations. * Corresponding Author: Mayer L. Calma  mlcalma@up.edu. ph International Journal of Biosciences | IJB | ISSN: 2220-6655 (Print), 2222-5234 (Online) http://www.innspub. net Vol. 16, No. 2, p. 382-393, 2020
Do Patients Treated For Voice Therapy With Telepractice Show Similar Changes In Voice Outcome Measures As Patients Treated Face To Face?

Clinical Question: Do patients treated for voice therapy with telepractice show similar changes in voice outcome measures as patients treated face-to-face? Method: Systematic Review. Study Sources: MEDLINE, PubMed, Google Scholar, ASHA journals. Search Terms: Voice therapy OR telepractice OR telehealth OR telerehabilitation. Number of Included Studies: 6. Primary Results: Delivery of voice therapy by telepractice provided positive outcomes comparable to face-to-face delivery. Number of studies employing quantitative data is relatively limited, restricting generalization of results. Conclusions: The goal of the speech-language pathologist is to maximize functional outcomes for individuals with communication disorders. Evidence found in this literature review for the effectiveness of telepractice delivery for the treatment of voice disorders indicates that treatment outcomes are comparable to face-to-face therapy and shows promising scope for this mode of service delivery. Rangarathnam, B. , Gilroy, H. , & McCullough, G. H. (2016). Do patients treated for voice therapy with telepractice show similar changes in voice outcome measures as patients treated face-to-face? EBP Briefs, 11(5), 1–6. Bloomington, MN: NCS Pearson, Inc. Publisher version of record available at: www.pearsonassessments. com Do Patients Treated for Voice Therapy With Telepractice Show Similar Changes in Voice Outcome Measures as Patients Treated Face-to-Face?
The Impact of Twitter on Government Organizations in KSA

Government Organizations or Firms (GOFs) are interested in understanding aspects related to Governments’ vision, mission, objectives and goals in order to formulate Information Systems (IS) and Information Technology (IT) strategies by determining and prioritizing best IS and IT technologies, which assist in achieving these goals. Twitter has spectacularly appealed to many people all around the world regardless of gender, age or qualification. This research paper explores and addresses the role of Twitter in GOFs that provides an answer to the question why GOFs must give great attention to Twitter? From experiences and literature review, we found that there are many business aspects that are greatly influenced by Twitter such as Research & Development, Marketing & Advertisements, Customer Relationship Management, Human Resources, Marketing Study, Total Quality Management, Forecasting and Risk Management. On that basis, the role of Twitter in GOFs, which are key enablers of effective business strategic planning, intrinsic strategic success criteria and drivers toward excellence. A case study has been carried out in one of the top telecommunication company of Kingdom of Saudi Arabia (KSA). The results of the case study (Passports) affirms that they are mainly using Twitter in three business activities marketing, advertising and customer service that affect the company’s strategic planning critically.
The Impact of Air Pollution on Attributable Risks and Economic Costs of Hospitalization for Mental Disorders

This study aims to fill the gap in our understanding about exposure to particulate matters with diameter less than 2.5 μm (PM2.5) and attributable risks and economic costs of mental disorders (MDs). We identify the relationship between PM2.5 and risk of hospital admissions (HAs) for MDs in Beijing and measure the attributable risk and economic cost. We apply a generalized additive model (GAM) with controls for time trend, meteorological conditions, holidays and day of the week. Stratified analyses are performed by age, gender and season. We further estimate health and economic burden of HAs for MDs attributable to PM2.5. A total of 17,252 HAs for MDs are collected. We show that PM2.5 accounts for substantial morbidity and economic burden of MDs. Specifically, a 10 μg/m3 daily increase in PM2.5 is associated with a 3.55% increase in the risk of HAs for MDs, and the effect is more pronounced for older males in colder weather. According to the WHO's air quality guidelines, 15.12 percent of HAs and 16.19 percent of related medical expenses for MDs are respectively attributable to PM2.5.
Substitution in Bilateral FDI: Theory and Evidence from Global FDI Firm Data

This paper builds a theory to characterize the impact of institutional quality on productivity and profitability of firms. MNEs headquartered in countries of poorer state institutions are shown to invest more in ‘informal institutions’. Firms from countries of good "formal" institutions tend to invest in countries with "not so good" institutions to save on production cost since those host countries tend to have lower wage levels. On the contrary, their counterparts from countries with "not so good" institutions tend to invest in countries of "good" institutions to save on fixed cost which is partly composed by invests in "informal institutions". For the most productive firms, MNEs on average generate more net profits in countries of better institutions, the poorer the institutional environment at home. The above proposition is confirmed using global firm level FDI data. ∗PhD student, School of Economics, Singapore Management University
Inhibitors of the Fanconi anaemia pathway as potential antitumour agents for ovarian cancer

The Fanconi anaemia (FA) pathway is an important mechanism for cellular DNA damage repair, which functions to remove toxic DNA interstrand crosslinks. This is particularly relevant in the context of ovarian and other cancers which rely extensively on interstrand cross-link generating platinum chemotherapy as standard of care treatment. These cancers often respond well to initial treatment, but reoccur with resistant disease and upregulation of DNA damage repair pathways. The FA pathway is therefore of great interest as a target for therapies that aim to improve the efficacy of platinum chemotherapies, and reverse tumour resistance to these. In this review, we discuss recent advances in understanding the mechanism of interstrand cross-link repair by the FA pathway, and the potential of the component parts as targets for therapeutic agents. We then focus on the current state of play of inhibitor development, covering both the characterisation of broad spectrum inhibitors and high throughput screening approaches to identify novel small molecule inhibitors. We also consider synthetic lethality between the FA pathway and other DNA damage repair pathways as a therapeutic approach.
Phylogeny, evolutionary morphology, and hemipenis descriptions of the Middle American jumping pitvipers (Serpentes: Crotalinae: Atropoides)

The jumping pitvipers, genus Atropoides, occur at low to middle elevations throughout Middle America. Recent molecular phylogenetic analyses have included all six species of Atropoides, but only two studies have found Atropoides to be monophyletic and questions persist about relationships within the A. nummifer complex. In this study, our phylogenetic analyses of morphological data provide strong support for the monophyly of Atropoides and recover relationships within the genus that are mostly congruent with those of recent molecular studies, further supporting the evolutionary and biogeographic hypotheses proposed in those studies. Our analyses find support for a sister relationship between A. picadoi and the other Atropoides species and an A. occiduus–A. indomitus clade sister to an A. nummifer–A. mexicanus–A. olmec clade. Within the A. nummifer complex, we find A. mexicanus and A. olmec to be sister species to the exclusion of A. nummifer. We include morphological synapomorphies to support each clade within Atropoides and describe and illustrate the hemipenes of each species. In addition, we discuss the importance of morphological phylogenetics and the functionality and limitations of hemipenial data in systematics.
RECONSTRUCTION OF FLOOD EVENTS AND LINKS WITH CLIMATIC FACTORS: A CASE STUDY OF THE SAINT-FRANÇOIS BASIN

Many rivers of the Saint-François Basin are prone to frequent flooding, which affects several of the region’s communities. This was mainly due to heavy spring floods or ice jams on the river, which caused water levels to rise rapidly and river banks to overflow. In some cases, major flooding was caused by heavy summer or fall rain. The first objective of this study deals with the historical and chronological reconstruction of flood events, as well as the identification of the major floods that occurred in the last century. The second objective deals with the analysis of precipitation data and streamflow variations (discharge) over the past century and their link to the recurrence of flooding. Variations in river flow are also studied with respect to the major floods which have occurred over the past century in this area. The historical reconstruction of flood events in the study area was done using data obtained from different sources (e.g. government reports, regional monographs), and the hydrometeorological data provide from the database of governmental agencies. It can be noted that the flood rate has been on the rise since the 1970s, especially from 1970 to 1990. There appears to be a certain decrease in the flood frequency after this period. The fluctuations noted in terms of the rainfall and hydrological data follow roughly the same trends, which can also be found in flood frequency variations. The hydroclimatic factors (precipitation, streamflow) appear to play a major role in the increase of flooding in this area. Furthermore, anthropogenic factors may play a role in the exacerbation of flooding, but their impact is still difficult to determine.
Identification of peptides sequence and conformation contributed to potential allergenicity of main allergens in yogurts

Yogurts provide a good source of nutrition and may induce tolerance in people with cow’s milk allergy (CMA). This study aimed to investigate the IgE-binding capacity of main allergens in the different yogurts which provide a reference for people with a high risk of CMA, and analyze the epitopes of major allergen peptides in yogurt. We assessed the degradation and the allergenic properties of major allergens in six commercial yogurts and fresh milk. The degradation of major allergens was analyzed by SDS-PAGE and RP-HPLC. Western blot and ELISA experiments detected allergenic characteristics by using specific sera. The results showed that β-lactoglobulin (Bos d 5) and α-lactalbumin (Bos d 4) were obviously degraded in yogurts but caseins were still present in abundance, which indicated that the proteases in yogurts were specific to whey proteins. IgE and IgG binding ability of major allergens were obviously reduced in yogurts, especially GuMi yogurt. In addition, 17 peptides of major allergens in GuMi yogurt were identified by LC-MS/MS and most of them were located in the interior of the spatial structure of proteins. Among them, 8 peptides had specific biological functions for health benefits, such as antibacterial, antioxidant, and ACE-inhibitory. We also found that 6 and 14 IgE epitopes of Bos d 5 and caseins were destroyed in GuMi yogurt, which could lead to the reduction of IgE-binding capacity. Meanwhile, peptides [Bos d 5 (AA15–40), Bos d 9 (AA120–151, AA125–151)] also preserved T cell epitopes, which might also induce the development of oral tolerance. Therefore, this study suggested that the sequence and conformation of peptides in yogurts contributed to hypoallergenicity. Graphical Abstract Analysis of epitope peptides in yogurts.
Production of Heavy Flavor and Quarkonia at CDF

The production cross sections and polarizations of Υ mesons in hadron collisions are im-portant observables with which to test diﬀerent QCD models at low energy. This article describes the CDF measurement of the spin alignment of the Υ(1 S ) , Υ(2 S ) and Υ(3 S ) states produced at the Tevatron using a data sample of 6.7 fb − 1 . Compared to earlier CDF measurements, it extends the analysis technique in several ways. A new method to estimate the background angular distribution is used, a full angular analysis is performed for the ﬁrst time and a consistency check is carried out by using two diﬀerent reference frames. It is also the ﬁrst measurement of the spin alignment of the Υ(3 S ) .
CONTENT-SPECIFIC THEORY ELEMENTS FOR EXPLAINING AND ENHANCING TEACHERS’ PROFESSIONAL GROWTH IN COLLABORATIVE GROUPS

In order to explain and enhance teachers’ professional growth in collaborative groups, sociocultural theoretical perspectives and the construct of community of inquiry have been established. This plenary paper builds upon these achievements and suggests eight kinds of theory elements that can refine these perspectives and allow theorizing in more content-specific ways, where content refers to both, classroom content and PD content. The paper suggests an adapted model for professional growth as the framework for content-specific theorizing.
SAHİBİ VE SORUMLU MÜDÜR/OWNER AND RESPONSIBLE MANAGER

A Turkish and an English abstract should be submitted with all submissions except for Letters to the Editor. Submitting a Turkish abstract is not compulsory for international authors. The abstract of Original Articles should be structured with subheadings (Objective, Materials and Methods, Results, and Conclusion). Abstracts of Case Reports and Reviews should be unstructured. Please check Table 1 below for word count specifications.
An outbreak of measles in gold miners in River Nile State, Sudan, 2011.

Background Despite the wide use of vaccination, measles outbreaks still occur. Aims This study assessed cases notified during a measles outbreak in northern Sudan in 2011 and the response of the health authorities to contain the outbreak. Methods The records of all measles cases reported to the River Nile State health ministry in 2011 from the Abu Hamad locality, a gold-mining area, were reviewed together with the actions of the health authorities at the time of the outbreak. Seventeen gold-mining clusters were included. Data on demographic, clinical, geographic and chronological characteristics of the cases were extracted. Results The outbreak occurred from 27 January to 3 May 2011 with the peak in epidemiological week 9. A total of 445 measles cases were recorded, giving an incidence of 27.1 per 10 000 of the mining and resident population. Most cases (87.4%) were aged between 15 and 34 years. High fever was the most common symptom (99.3% of the cases), followed by conjunctivitis (80.4%); haemorrhage was recorded in 29.4%. Most cases (84.9%) were unvaccinated. Six deaths occurred (case fatality: 1.3%); two from cerebral coma and four from haemorrhagic shock. Severity of disease was significantly associated with place of origin of the cases (P = 0.003). Conclusion The measles outbreak in the gold-mining areas in Abu Hamad had serious consequences attributed to poor environmental conditions, overcrowding, poor nutrition and lack of vaccination. The health authority response helped end the outbreak. The local health authority should consider the gold-mining areas as a potential risk to public health in their future plans.
Fertility Decisions and Employment Protection: The Unintended Consequences of the Italian Jobs Act

We study the effect of a reduction in employment protection on fertility decisions. Using data from the Italian Labor Force Survey for the years 2013-2018, we analyze how the propensity to have a child has been affected by the 2015 Labor Market Reform, the so-called "Jobs Act", which has essentially reduced the employment protection for large-firm employees and leaved largely unchanged that for small-firm ones. We employ a Difference-in-Differences identification strategy and compare the average change over time in fertility decisions of women employed in large firms with the average change experienced by women employed in small firms. We find that women exposed to the reduction in employment protection have a 1.4 percentage point lower probability of having a child than unexposed women. A battery of robustness checks confirms this finding. We document large heterogeneous effects by marital status, parity, geographic areas as well as by the level of education and wage. Our findings help understand the potential unintended consequences that reforms introducing more labor market flexibility have on fertility decisions by increasing insecurity on career prospects.
Development and Validation of the Middle Grades Computer Science Concept Inventory (MG-CSCI) Assessment

The increasing interest in computer science (CS) and CS-integrated STEM teaching and learning has created a need for assessment instruments that can be used to evaluate the efficacy of innovative instructional approaches to K-12 CS education. However, there is a lack of validated assessment tools aligned to core CS concepts for younger students. This paper reports on the development and validation of a CS concept assessment for middle grades (ages 11-13) students. A total of 27 multiple-choice items were developed, guided by focal knowledge, skills and abilities associated with the concepts of variables, loops, conditionals, and algorithms. These items were administered to 457 middle grades students. The items were presented in form of block-based programming code and administered in a week-long computational modeling intervention. A combination of classical test theory and item response theory approaches were used to validate the assessment. Based on results, it was found that only 24 items are considered valid and reliable items to measure CS conceptual understanding. The results also suggested that the assessment can be used as a pre and post-test to investigate students’ learning gains. This work fills an important gap by providing a key resource for researchers and practitioners interested in assessing middle grades student CS conceptual understanding.
Adapting Technology Acceptance Model to Predict Attitudes Toward Using E-Management Exploratory study of the views of the heads of the scientific departments at the University of Duhok

This study aimed to present the concept of (TAM) and e-management, and use the two constructsof TAM (perceived ease of use and perceived usefulness) as perceptual determinants for attitudes toward using emanagement at the University of Duhok. The study adopted the descriptive approach, and utilized the questionnaire for data collection. The study society consisted of all Heads of scientific departments at the university during the academic year 2016/2017 (N=52). The questionnaire was distributed to all members of the study society, and the response rate was (100%). A numerous of statistical methods were used to analyze the data and test the hypotheses which provided for the existence of significant correlation and impact between both perceived ease of use and perceived usefulness and the attitudes towards using e-management. The results of study showed that most of the respondents held a positive attitude towards using emanagement. The results also showed that there is a statistically significant impact of both perceived ease of use and perceived usefulness on the attitudes towards using e-management, with moral significance at (P ≤ 0.01). The study presented a set of suggestions among them developing training programs that raise the level of perceived ease of use and perceived usefulness of e-management among administrative leaders in the university, and qualify them to deal with the use of e-management.
Subjective Expectations, Social Security Benefits, and the Optimal Path to Retirement

Americans face the challenges of retirement with varying degrees of preparation. Evidence indicates that that many individuals may not be making the best possible choices with respect to their Social Security and retirement savings. We assess the subjective expectations of non-retirees and find that they have sizable biases and uncertainty about future retirement benefits. This uncertainty and the level of subjective expectations can affect workersâ€™ wealth accumulation and retirement readiness. We build on these observations and combine unique survey data with a life-cycle optimization model to measure the role of Social Security literacy, subjective expectations about retirement benefits, and behavioral traits as determinants of life-cycle savings decisions and welfare. The goal of this project is to better understand the role of retirement expectations as determinants of savings decisions and retirement income. We forecast future benefits and measure the bias in expectations. We find heterogeneity in the direction of the expectation bias: Men and those with low levels of uncertainty about retirement benefits are less likely to overestimate their future retirement benefits, hence are more likely to save more and reach retirement better prepared. We find that these biases in subjective expectations translate into suboptimal asset accumulation and welfare losses.