Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunohistochemical Investigation of Lipid Peroxidation in Renal Coccidiosis of Geese

Objective: In this study, we aimed to evaluate the oxidative damage caused by lipid peroxidation due to renal coccidiosis by histopathological and immunohistochemical methods. Material-Method: The material of this study was made up of tissue samples taken from 139 geese whose average age was 10 weeks, who were brought to our department dead between 2013-2020. Tissue samples taken were fixed in 10% buffered formaldehyde solution. 5 µm-thick sections were taken from the paraffin blocks prepared after routine tissue follow-up procedures. Hematoxylin & Eosin staining was applied to the sections in order to detect histopathological changes. Sections were examined and photographed under a light microscope. Results: Various clinical signs such as fever, respiratory distress, weakness, anorexia, tremors, inability to get up from the ground, balance disorders, rotational movement, diarrhea, wheezing were detected in geese. In systemic necropsies of geese, large and small white nodular structures were detected in the kidney. In histopathological examinations, coccidiosis agents ( E. truncata ) were found in the tubular epithelium of the kidney. Necrosis and mononuclear cell infiltration were observed in the tubules due to the presence of E. truncata . In addition, edema and hyperemia in the lungs, multifocal necrosis in the liver, cell infiltration in the portal spaces and enteritis were other important histopathological findings. In one case, aspergillosis was detected together with renal coccidiosis. We observed that MDA expression was more severe in oocyst stages, which is the mature form of the parasite, compared to other parasitic life stages. Conclusion: Based on the results obtained from this study, it was revealed that renal coccidiosis in geese caused lipid peroxidation / oxidative damage through the increase in MDA expression.
Bolstering responsible management education through the sustainable development goals: Three perspectives

Acknowledging the roles and responsibilities of business in society and the importance of realizing the Sustainable Development Goals (SDGs), contemporary management education is characterized by the integration of a rich palette of initiatives in the field of Responsible Management Education (RME). It is important though to recognize that these initiatives, however laudable, so far represent rather basic, and thus insufficient, ways of truly integrating sustainability into management education. This Provocation to Debate essay therefore identifies three perspectives for bolstering RME through the SDGs: (1) addressing the fact that SDGs incorporate trade-offs, tensions, and paradoxes; (2) realizing the SGDs implies engaging in systemic activism; and (3) embracing the SDGs comes with emotional affect. As such, this essay is an invitation to critically reflect on the roles and contents of management education in spurring sustainable development and to engage in a meaningful discussion about the value and the limitations of the SDGs for advancing the RME agenda.
Zeolite modified with copper oxide and iron oxide for lead and arsenic adsorption from aqueous solutions

How to completely remove toxic metals from water is still a serious challenge, and is the mission that faces researchers and scientists today. In this work, zeolite/copper oxide (CuO) and zeolite/iron oxide (Fe3O4) nanocomposites (NCs) were prepared via a co-precipitation method. Several techniques were used for characterization of the prepared NCs including UV-visible, powder X-ray diffraction, N2 adsorption for determining the specific surface areas (Brunauer–Emmett–Teller (BET)) and pore volumes. The morphology was investigated by field emission scanning electron microscopy. The batch adsorption experiment process was used to study the applicability of the prepared NCs to removing lead (Pb) and arsenic (As) from aqueous solutions. The effects of the adsorbent dosage, pH, initial metal concentration and contact time on the adsorption process were investigated. The obtained results revealed that in 40 minutes 0.15 g of prepared zeolite/Fe3O4 (NCs) was able to remove 97.2% of Pb and 96.8% of As from 100 mg/L aqua solutions at a pH of between 4 and 6. The Langmuir isotherm model showed higher correlation coefficients and provided better agreement with the experimental data. The adsorption kinetic is a chemi-physisorption process that follows the pseudo second-order kinetic model.
Phenotypic Responses to Selection for Ultrafine Wool in Uruguayan Yearling Lambs

This study evaluated the phenotypic trends for wool and growth traits of the fine Merino genetic nucleus in Uruguay. Data were collected from one-year-old lambs over a twenty-year period (1999–2018). The overall aim of the selection flock was to reduce fiber diameter with concomitant increases in fleece and live weights. Traits analyzed included fiber diameter (FD), greasy fleece weight (GFW), coefficient of variation of FD (CVfd), staple length (SL), scoured yield (SY), live weight post-shearing (LW), eye muscle area (EMA) and fat thickness (FAT). Data from approximately 5300 one-year-old male and female lambs were analyzed. During the study period, FD decreased by approximately 3 µm, whereas GFW and LW increased by at least 0.5 and 3.0 kg, respectively. There were interactions between the sex of the individual and the year for all wool traits. Except for FAT, all other traits were affected by the dam age. This study indicates that the selection program applied in the fine Merino genetic nucleus over a twenty-year period resulted in reductions in FD and increases in GFW and LW. Therefore, the results indicate it is possible to produce ultrafine wool in semi-extensive grazing systems without compromising other economically relevant traits in one-year-old lambs.
Radiological Characteristics of Patients Infected with Coronavirus Disease-2019 (COVID-19): A Retrospective, Observational Study from Iran

Background: Management of Covid-19 patients is key to control the pandemic. In this line, access to chest Computed Tomography (CT) scan findings and investigating changes during initial diagnosis until recovery is of crucial importance. Objectives: The present study aimed to investigate the chest CT-scan findings of patients with a definitive diagnosis of Covid-19 in Guilan, Iran. Methods: In this retrospective study, 1000 patients with a definitive diagnosis of Covid-19, from 20 April to 30 July 2020, were enrolled. Their first and follow-up chest CT-scans were obtained. Total lung involvement was determined by the number of lobes involved and by scoring 0 to 5 for each lobe (5 lobes, lowest score: 0, and highest score: 25). Results: In this study, three CT-scans of all 1000 patients were studied. Patients were classified into 4 stages according to their hospitalization duration (ranging from 0 to 30 days): stage 1 or primary (0 to 7 days): ground-glass opacities (n = 178 or 89%), stage 2 or progressive (8 to 15 days): increased crazy-paving pattern (n = 89 or 44.5%), stage 3 or peak involvement (16 to 22 days): consolidation (n = 78 or 89%), and stage 4 or decreased pulmonary involvement severity (greater than 23 Day): the gradual resolution of consolidation (n = 178 or 89%). Conclusions: Chest CT-scan findings revealed that patients with Covid-19 had a high rate of pulmonary involvement, on average, for the first 15 days, which then declined.
Grandparent Affection and Emotional Well-being of Adolescents with Different Family Types

Despite the increasing importance of grandparents in raising their grandchildren, few studies analyze the impact that these intergenerational relationships have on the grandchildren, especially during adolescence. With a sample of 3432 adolescents between 11 years and 16 years old, we analyze to what degree grandparent affection explains adolescent emotional well-being. The results reveal interesting findings according to family type: traditional two-parent families, families with joint custody, or families with only one biological parent (specifying between father or mother). Lastly, we analyze and discuss the implications of the relevant results related to the grandparents’ sex, lineage, and state of health, the adolescent’s age, as well as finding a higher impact of grandparent affection has on adolescents from families with only the father as a reference figure. This study advocates for reinforcing the role of the grandparents during adolescence, becoming especially relevant for boys and girls living in father-only families.
Analysis of the Effect of Information Quality and Easiness on Satisfaction through User Trust of SIAKAD University of Merdeka Malang,Indonesia

This study aims to analyze the influence of information quality and ease on trust, to analyze the influence of information quality and ease on user satisfaction, to analyze the effect of trust on user satisfaction and to analyze information quality and ease on user satisfaction through the trust of SIAKAD Unmer Malang. The sample in this study were 75 students. The data analysis technique used path analysis. Based on the results of the analysis, it shows that the quality of information and ease have an effect on trust, which means that quality SIAKAD information supported by ease of operation can increase trust. Information quality and ease have an effect on user satisfaction. This means that user satisfaction can be built through the provision of quality information and ease of use of SIAKAD. Trust affects user satisfaction, which means thatuser trust can build user satisfaction because ease of use is reflected in being satisfied with the information presented at SIAKAD making it easier for activities. Trust mediates the effect of information quality and ease on user satisfaction. This means that user satisfaction can be built if users feel that the information presented is of high quality and makes it easy to operate SIAKAD.
Establishing and Deepening Brand Loyalty through Brand Experience and Customer Engagement: Evidence from Taiwan’s Chain Restaurants

ABSTRACT Since prior works have overlooked the complexities of two broad constructs, i.e., brand experience and customer engagement, this study selects restaurant-specific dimensions, and examines how these detailed dimensions influence brand loyalty, particularly in chain restaurants. Secondly, while prior studies have discussed relationships among brand experience, customer engagement, and brand loyalty, the mediating mechanism(s) remain unclear, thus, this study examines how customer engagement mediates these relationships, based on 280 questionnaires collected from customers of Taiwan’s chain restaurants, and analyzed using Partial least squares Structural Equation Modeling (PLS-SEM). This study’s results are as follows: 1) Affective experience is a main driver of customer engagement; 2) Sensory experience has a significant impact on cognitive engagement, but not on emotional engagement; esthetical experience impacts emotional engagement, but not cognitive engagement; 3) Emotional engagement is a main driver of brand loyalty, followed by cognitive engagement; 4) Emotional engagement is a main mediator in establishing and deepening brand loyalty.
Organizational Form and Trade Liberalization: Plant-Level Evidence

This paper studies how firms’ internal organization shapes the impact of international trade. Using establishment-level data from the U.S. Census and a difference-in-difference specification, I find that, relative to standalone firms, conglomerates are more likely to restructure after trade liberalization episodes, focusing on their core competency and improving firm productivity and product market performance. Adjustments through the extensive margin account for the majority of the productivity growth differential between conglomerates and standalones experiencing trade shocks. Aggregate industry productivity remains relatively unchanged in industries dominated by conglomerates’ core business but decreases significantly in others. My findings suggest that firms’ internal organization has important consequences on the effects of trade policies. This paper was accepted by Gustavo Manso, finance.
Interleukin-4 Cytokine as an Indicator of the Severity of Tuberculous Lymphadenitis

BACKGROUND: Interleukin-4 (IL-4) is a cytokine of Th2 response and plays a role as a reducer or silencer of Th1 work. It is more related to allergic processes, with consequent loss of control of the disease (i.e., tuberculosis). Interferon gamma (IFN-γ) is a Type II interferon that inhibits Th2 immune response and inducts Th1 immune response to inhibit tuberculous and viral replication, and any immunostimulatory and immunomodulatory effects. Dark specks (DS) are in the background of eosinophilic granular material seen in aspirations of tuberculous lymphadenitis stained with May–Grunwald Giemsa (MGG). A lesion with DS festers and the disease worsens. AIM: This study determines whether the expression of IL-4 is associated with disease severity and compares incidences of expression of IL-4 and IFN-γ in DS lesions. MATERIALS AND METHODS: This study includes 100 diagnostic cases of tuberculous lymphadenitis, which were not successfully treated with common antibiotics, but responded to anti-tuberculous drugs (ex juvantibus diagnosis). Out of the 100 cases, 59 cases were with DS and 41 cases were without DS. Out of the 59 cases with DS, 49 cases were IL-4 positive (+) and 10 cases IL-4 negative (–). Of the 41 cases without DS, 10 cases were IL-4 (+) and 31 cases were IL-4 (–). Out of the 59 cases of DS, there were 31 cases with expressions of IL-4 (+) and IFN-γ (–); zero case with IL-4 (–) and IFN-γ (+); 18 cases with IL-4 (+) and IFN-γ (+); and 10 cases with IL-4 (–) and IFN-γ (–). Antigen expressions were determined using rabbit polyclonal to IL-4 (IL-4, ab9622) and rabbit polyclonal to IFN-γ (IFN-γ, ab9657), Abcam. Statistical evaluations were performed using the Chi-square test and Fisher’s exact test. Any p < 0.05 was statistically significant. RESULTS: Expression of IL-4 significantly associated with disease severity, compared to IFN-γ expression (p < 0.05). In lesions with DS, IL-4 is more frequently expressed compared with IFN-γ. CONCLUSION: IL-4 can be a beneficial indicator of the severity of tuberculous lymphadenitis.
ADAM10 and ADAM17 in Liver Regeneration and Fibrosis: Regulation of EGFR, c-Met and TNF RI Signalling

ADAM10 and ADAM17 are proteases that affect multiple signalling pathways by releasing molecules from the cell surface. As their substrate specificities partially overlaps, we investigated their concurrent role in liver regeneration and fibrosis, using three liver-specific deficient mouse lines: ADAM10- and ADAM17-deficient lines, and a line deficient for both proteases. In the model of partial hepatectomy, double deficient mice exhibited decreased AKT phosphorylation, decreased release of EGFR activating factors and lower shedding of HGF receptor c-Met. Thus, simultaneous ablation of ADAM10 and ADAM17 resulted in impaired EGFR signalling, while HGF/c-Met signalling pathway was enhanced. In contrast, antagonistic effects of ADAM10 and ADAM17 were observed in the model of chronic CCl4 intoxication. While ADAM10-deficient mice develop more severe fibrosis manifested by high ALT, AST, ALP and higher collagen deposition, combined deficiency of ADAM10 and ADAM17 surprisingly results in comparable degree of liver damage as in control littermates. Therefore, ADAM17 deficiency is not protective in fibrosis development per se, but can ameliorate the damaging effect of ADAM10 deficiency on liver fibrosis development and results in decreased shedding of TNF RI, while ADAM10 deficiency leads to increased levels of soluble TNF RI in serum. In conclusion, hepatocyte-derived ADAM10 and ADAM17 are important regulators of growth receptor signalling and TNF RI release, and pathological roles of these proteases are dependent on the cellular context.
Embodying rhythmic properties of a foreign language through hand-clapping helps children to better pronounce words

This study tested the effects of hand-clapping to the rhythm of newly learned French words on the pronunciation of these words by 7- to 8-year-old Catalan children. In a short training experiment with a pre- and posttest design, 28 children either repeated cognate words in French (e.g. French aspirateur, Catalan aspirador ‘vacuum cleaner’) while clapping to the rhythmic structure of those words or only repeated the words. Participants’ oral productions before and after training were rated for accentedness by three French native speakers. Results showed that in both groups, participants’ pronunciation improved after training, and crucially, children in the clapping group improved significantly more than those in the non-clapping group. Additionally, an acoustic analysis of the duration of word-final vowels indicated that only children in the clapping group significantly lengthened the final vowel after training, thus producing more target-like durational patterns. Our results suggest that a brief embodied intervention based on highlighting the rhythmic structure of words through hand-clapping has the potential to enhance pronunciation in a foreign language. The implications for second language teaching of pronunciation are discussed.
Low-noise terahertz-wave detection by InP/InGaAs Fermi-level managed barrier diode

The noise performance of an InP/InGaAs Fermi-level managed barrier diode (FMB diode) in terahertz-wave detection was investigated by combining a bowtie-antenna-integrated FMB diode with a preamplifier. The fabricated quasi-optical FMB diode module demonstrated broadband signal detection at frequencies ranging from 160 GHz to 1.4 THz with a peak sensitivity of 3.2 MV/W. The lowest noise-equivalent-power of 3.0 pW/ with a wide dynamic range of more than five decades was achieved at 300 GHz.
Children’s Astronomy. Development of the Shape of the Earth Concept in Polish Children between 5 and 10 Years of Age

The Earth’s shape concept develops as consecutive cognitive problems (e.g., the location of people and trees on the spherical Earth) are gradually resolved. Establishing the order of problem solving may be important for the organisation of teaching situations. This study attempted to determine the sequence of problems to be resolved based on tasks included in the EARTH2 test. The study covered a group of 444 children between 5 and 10 years of age. It captured the order in which children solve cognitive problems on the way to constructing a science-like concept. The test results were compared with previous studies. The importance of cultural influences connected to significant differences (24%) in test results was emphasised. Attention was drawn to the problem of the consistency of the mental model approach highlighted in the literature. The analysis of the individual sets of answers provided a high level of consistency of indications referring to the same model (36%), emphasising the importance of the concept of mental models.
Are single-sex schools more effective than the coed ones? The effect of single-sex schooling on achievement among female adolescents in Catholic schools

ABSTRACT This study inquired into the effect of single-sex schooling on achievement of female adolescents. It used national examination data of 4,787 Polish female students (10 cohorts) attending single-sex and co-educational Catholic schools. We tested two sets of partially contradictory predictions derived from two different theoretical models explaining how and why achievement of female students in the two types of school may differ. The results of cross-classified random-effects regression models showed that after controlling for initial student and school differences female adolescents attending all-girls schools scored higher on the lower-secondary school exam in science and the humanities in comparison to those who attended co-educational schools. However, the difference was statistically significant only for science. The results were fully consistent with neither of the two adopted theoretical models, although provided more support for the one drawing upon peer effects. Although the effect of 17% of the exam scores standard deviation could be considered small, it appeared in the results of a high-stakes exam. Since the examination results were the main criterion for admission to the next-stage school, attending an all-girls school might significantly affect future educational career and job opportunities of young women.
Dynamical and Trace Gas Responses of the Quasi‐Biennial Oscillation to Increased CO2

Long‐term projections of the Quasi‐Biennial Oscillation (QBO) remain uncertain. Using the high‐top “Middle Atmosphere” (MA) version of the NASA Goddard Institute for Space Studies (GISS) ModelE (E2.2‐AP), we show that increased CO2 reduces the QBO period and weakens its amplitude, consistent with results from recent multimodel studies. The amplitude response is asymmetric, with the easterly phase weakening more than the westerly phase. Results from both coupled atmosphere‐ocean and climatologically fixed sea surface temperature simulations link the period response to changes in parameterized convective gravity wave fluxes, whereas the amplitude changes are more closely tied to changes in tropical upwelling. Comparisons of simulations with and without ozone‐dynamical feedbacks reveal that ozone feedbacks increase the QBO amplitude and period in pre‐industrial control simulations, and reduce the response of the amplitude to increased CO2. The response of stratospheric tracers to projected changes in the QBO is also investigated. Similarity between results using fully interactive (trace gas and aerosol) versus linearized ozone chemical mechanisms suggests that the QBO response to CO2 does not depend on additional chemical feedbacks beyond those associated with ozone, which implies that projected QBO changes may be credibly represented using simplified stratospheric ozone schemes.
Implementation of physical, sports, and health education facilities

To the Physical, Sports, and Health Education, facilities have been one of the factors that support the successful assessment of learning results. with reference to the statement, the conduct of the study aims at identifying the implementation of Physical, Sports, and Health Education facilities management. During the conduct of the study, the subjects that had been selected were the Physical, Sports, and Health Education teachers and the School Principals of State 26 Elementary School and State 89 Elementary School in the City of Bengkulu. Then, the nature that had been adopted for the study was the qualitative research and the data were gathered by means of observation. During the observation, the notes on the condition, the inventory, the maintenance, and the implementation of the facilities management were collected. The results of the study show that the management of Physical, Sports, and Health Education facilities has not been properly implemented. The results have been confirmed by the following findings: (1) the condition of the existing Physical, Sports and Health Education facilities is not fit for operation anymore; (2) the number of the Physical, Sports, and Health Education facilities is unfit; (3) the inventory for the Physical, Sports, and Health Education facilities is not properly implemented; (4) the awareness for maintaining the Physical, Sports, and Health Education facilities are low; and (5) the removal of the Physical, Sports, and Health Education is not implemented yet