Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Asfotase Alfa on Plasma and Urine Pyrophosphate Levels and Pseudofractures in a Patient With Adult‐Onset Hypophosphatasia

Hypophosphatasia (HPP) is an inherited disease caused by variants of the ALPL gene encoding tissue‐nonspecific alkaline phosphatase. Adult‐onset HPP (adult HPP), known as a mild form of HPP, develops symptoms involving osteomalacia after the age of 18 years. Asfotase alfa (AA) is a modulated recombinant human alkaline phosphatase (ALP) that has been established as a first‐line therapy for severe forms of HPP, such as perinatal and infantile forms. We described a 64‐year‐old female who presented with pseudofractures in bilateral femur diaphyses and impaired mobility. Low serum ALP activity and a high concentration of urine phosphoethanolamine indicated the diagnosis of HPP, which was confirmed by the identification of a homozygous variant in the ALPL gene (c.319G > A; p.Val107Ile). An in vitro transfection experiment to measure the ALP activity of this novel variant protein was performed, resulting in 40% of the residual enzymatic activity compared with the wild type. AA was initiated to facilitate the union of pseudofracture and to improve mobility. After 6 months, radiographic images revealed the disappearance of fracture lines, and improvement of ambulatory ability was confirmed by the 6‐minute walk test (525 to 606 m). The EQ‐5D‐5L index was also improved (0.757 to 0.895). Within a follow‐up period, the levels of urine pyrophosphate corrected by urine creatinine (uPPi/Cre) declined in parallel with the level of plasma PPi (plasma PPi: 6.34 to 1.04 μM, uPPi/Cre: 226.8 to 75.4 nmol/mg). The beneficial effect of AA on pseudofracture healing in adult HPP was presented, although the application of AA should be restricted to patients exhibiting relatively severe manifestations. In addition, a novel pathogenic variant of the ALPL gene was identified with the supportive result of functional analysis. Furthermore, when monitoring patients with HPP treated with AA, uPPi/Cre might be a convenient substitute for plasma PPi, which requires immediate filtration after blood sampling. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.
(Bio)active Compounds in Daisy Flower (Bellis perennis)

The common daisy (Bellis perennis) belongs to the family Asteraceae and, in recent years, some new research has been published on the bioactive compounds and biological activities of its extracts. In 2014, the knowledge was partially summarized, but several new studies have been published in the last nine years. In addition, the substances were tabularly consolidated to give a comprehensive overview of over 310 individual components, compound classes, and bioactivities, as well as their accurate plant organ origin. The latest results have shown that the plant has antioxidative, antimicrobial, anticancerogenic, wound healing, antidepressive, anxiolytic, nephroprotective, and insulin mimetic effects, as well as an effect on lipid metabolism. Some studies in the field of homeopathy were also listed. Ideally, a biological effect and one or several compound(s) can be correlated. However, the compounds of the extracts used have often been qualified and quantified, but it remains unclear which of these substances have an activity. The works often stick at the level of the crude extract or a fraction, but not at a single purified and tested compound and, consequently, they are hampered by a missing comprehensive bioactivity workflow. This review provides a critical overview and gaps and offers a basis for further research in this area.
Enrolling the child in private early childhood education and care in the context of universal service provision

ABSTRACT Finland has traditionally had a universal early childhood education and care (ECEC) system like the other Nordic countries, but in the last 15 years this system has undergone considerable marketisation and privatisation suggested to enable parental choice of ECEC. Much of the existing research on parental ECEC decisions has been conducted in contexts where ECEC systems differ considerably from the welfare and educational regimes of the Nordic countries. Moreover, parents’ views of private ECEC have scarcely been studied in the context of universal service provision. This study examined the frames the parents of a four-year-old child use to justify the selection of a private ECEC centre for their child. The data comprised qualitative interviews with eight Finnish parents. By applying discourse analytic tools, four frames were differentiated: accessibility, pedagogy, ECEC facilities and security. The findings demonstrated that while the accessibility of the services in terms of location and opening hours was the basis on which “choice” of ECEC was possible, the parents acted as active agents in the ECEC markets looking for services that would correspond to their values and perceptions of good childhood. The study raises the question of how well public policies and services can meet parents’ expectations and adjust to increasingly prevalent ideals of individualisation in society.
OPTIMUM SPOT WEED CONTROL TREATMENT FOR A NEW ZEALAND RADIATA PINE (PINUS RADIATA) PLANTATION

A trial was established in the South Island of New Zealand to investigate the response of Pinus radiata to varying the area and duration of weed control around individual trees. Results after six years demonstrated that weed control was essential to ensure maximum survival and growth of Pinus radiata seedlings. Maintaining weed control for two seasons following planting resulted in marginally higher stand productivity than where weed control was applied in the year of planting only. A modelling approach was used to determine treatment effects in terms of a “time difference”, and to make inferences on long-term treatment effects. Without weed control, tree volume six years after planting was more than 1.5 years behind trees given complete weed control. Spot vegetation control resulted in similar tree growth to total control, as long as the area and duration of weed control was greater than a 1 m spot maintained for 1 year.
Effect of the intermediate principal stress on rock failure

Precise testing methods have been applied to an experimental study of the effect of the intermediate principal stress σ2 on failure of a granite, a limestone, and a dolomite rock at room temperature. σ2 affects failure in two ways. Strength at failure increases with σ2 by an amount that is proportional to, although smaller than, the amount of the least compression σ3; this effect of σ2 is much more pronounced for brittle than for ductile material. The angle between faults and maximum compression direction is markedly reduced as σ2 is increased from the value σ3 to σ1; this effect is pronounced for both brittle and ductile material.
Breeding frequency, clutch size, reproductive status and correlated behaviours in sympatric females Elaphe quatuorlineata and Elaphe longissima (Reptilia : Colubridae)

Le statut reproducteur, la taille des portees et les comportements lies a ces parametres ont ete etudies par suivi sur le long terme de femelles de deux especes de couleuvres sympatriques Elaphe quatuorlineata (n=6) et E. longissima (n = 5). L'etude a ete conduite dans une zone de collines mediterraneennes du centre de l'Italie (Monts de Tolfa, Latium). Elle a revele que les deux especes sont semblables en termes de frequence de la reproduction (la plupart des femelles portent chaque annee), de taille absolue des pontes (9,42 ± 1,86 oeufs pour E. longissima et 10,32 ± 1,25 oeufs pour E. quatuorlineata), de taille de la ponte relativement a celle de la femelle (0,08 ± 0.01 chez E. longissima et 0,07 ± 0,01 chez E. quatuorlineata), de periode de ponte (du 19 juillet au 2 aout) et de periode d'eclosion (fin aout). De plus, sont apparus chez les deux especes de faibles couts de mortalite associes a la post-oviposition. Les femelles d'E. quatuorlineata ont toutefois produit, d'annee en annee, des portees de meme taille, ce qui ne fut pas le cas de celles d'E. longissima. Aucune des annees de l'etude ne fut particulierement positive (ou negative) pour ce qui concerne la production par toutes les femelles examinees de portees plus importantes (ou plus faibles) que celles attendues de leur taille corporelle.
A New Approach to Shale Compaction and Stratigraphic Restoration, Beaufort-Mackenzie Basin and Mackenzie Corridor, Northern Canada (1)

Despite a long history of study, porosity reduction in shales and mudstones is still poorly understood. Many published shale compaction curves from different sedimentary basins exist, but it is difficult to make comparisons because of variations in sediment composition, geologic age, tectonic history, and experimental technique. The Beaufort-Mackenzie basin provides a unique opportunity to study shale compaction because it contains shales with rather uniform physical and chemical properties, deposited under highly variable sedimentation rates. The sonic log provides a sensitive measure of porosity change with depth in the Beaufort-Mackenzie basin. A new porosity-sonic transit-time equation, calibrated using shale and mudstone core porosity measurements from this basin, yields an acoustic formation-factor exponent of 2.19 and a matrix transit time of 220 microseconds/m, which are believed to be valid for low TOC (<2%), noncalcareous shales. Log-determined shale compaction curves define distinctive compaction zones that correlate with sedimentation rate, pore pressure, and erosion. Normal shale compaction is linear below 500 m at 1%/100 m decrease in porosity for hydrostatic pressure conditions. In eroded areas, the amount of missing strata can be estimated by reference to the normal compaction curve. In compositionally heterogeneous shale sequences, a knowledge of shale composition and its effect on log response is essential to avoid introducing significant error into calculated compaction curves. Preliminary results from the Brackett basin imply that maximum burial is more important than maximum paleotemperature in reducing shale porosity. This suggests that shale porosity could be a useful temperature-insensitive paleodepth indicator for eroded sedimentary sequences.
Association of Emergency Department Evaluation With Public Insurance Use and Treatment Delays for ACL Injury

Background: Utilization of an emergency department (ED) visit for anterior cruciate ligament (ACL) injury is associated with high cost and diagnostic unreliability. Hypothesis: Patients initially evaluated at an ED for an ACL injury would be more likely to be from a lower income quartile, use public insurance, and experience a delay in treatment. Study Design: Cohort study; Level of evidence, 3. Methods: Patients in the Rhode Island All Payers Claims Database who underwent ACL reconstruction (ACLR) between 2012 and 2021 were identified using the Current Procedure Terminology (CPT) code 29888. Patients were stratified into 2 cohorts based on CPT codes for ED or in-office services within 1 year of ACLR. A chi-square analysis was used to test for differences between cohorts in patient and surgical characteristics. Multivariable linear and logistic regression were used to determine how ED evaluation affected timing and outcome variables. Results: While adjusting for patient and operative characteristics, patients in the ED cohort were more likely to have Medicaid (29% vs 12.5%; P < .001) and be in the lowest income quartile (44.6% vs 32.1%; P < .001). ED visit and Medicaid status were associated with increased time to (1) diagnostic magnetic resonance imaging, adding 7.97 days on average (95% CI, 4.14-11.79 days; P < .001) and 8.40 days (95% CI, 3.44-13.37 days; P = .001), respectively; and (2) surgery, adding 20.30 days (95% CI, 14.10-26.49 days; P < .001) and 12.88 days (95% CI, 5.15-20.60 days; P = .001), respectively. Patients >40 years who were evaluated in the ED were 2.5 times more likely to require subsequent ACLR (odds ratio, 2.50 [95% CI, 1.01-6.21]; P = .049). Conclusion: In this study, patients who visited the ED within 1 year before ACLR were more likely to have a lower income, public insurance, increased time to diagnostic imaging, and increased time to surgery, as well as decreased postoperative physical therapy use and increased subsequent ACLR rates in the 40-49 years age-group.
Comparison of Estimated Wild Giant Anteater (Myrmecopahaga tridactyla Linnaeus, 1758) Diets with Commercial Diets for Insectivores: Implications for Anteater Health

Simple Summary Anteaters are insectivores, consuming diets consisting primarily of termites and ants in the wild; therefore, feeding them under human care has been a challenge and frequently leads to nutritional disorders. Through analysis of free-ranging giant anteaters’ stomach content, the findings of this study provide valuable information for optimizing anteater nutrition in zoological institutions and rehabilitation centers causing a significant impact on the welfare of the species. Abstract Using the stomach contents of 24 wild road-killed giant anteaters as proxies for their diet, we found that estimated wild diets were much lower in calcium (about ten times less) and phosphorus compared with manufactured feeds commonly fed to anteaters under human care. Indicators of soil consumption, such as ash, iron, and manganese were higher in the stomach contents than in either wild termites or manufactured diets, likely due to high levels of soil ingestion during feeding in the wild. Protein and fat levels in insects, stomach contents, and commercial diets all met carnivore recommendations. Both giant anteaters and tamanduas in managed care often develop hypercalcemia, perhaps because these taxa have an enhanced ability to retain calcium allowing them to survive on such low calcium diets. Results from this study indicate that, for anteaters in managed care, it is important to keep dietary calcium and vitamins D and K within recommended levels to prevent nutritional diseases such as hyper- and hypocalcemia and vitamin K deficiency.
APPLICATION OF THE PEBBLE COUNT NOTES ON PURPOSE, METHOD, AND VARIANTS 1

ABSTRACT: The pebble count procedure (Wolman, 1954) is the measurement of 100 randomly selected stones from a homogeneous population on a river bed or bar, which yields reproducible size distribution curves for surficial deposits of gravel and cobbles. The pebble count is widely used in geomorphologr (and increasingly in river engineering) to characterize surficial grain size distributions in lieu of bulk samples, for which adequate sample sizes become enormous for gravels. Variants on the original method have been proposed, one of which, the so‐called ‘zig‐zag’ method (Bevenger and King, 1995), involves sampling along a diagonal line and drawing data points from many different geomorphic units. The method is not reproducible, probably because it incorporates stones from many different populations, and because an inadequate number of grains is sampled from any given population. Sampling of coarse bed material should be geomorphically stratified based on the natural sorting of grain sizes into distinct channel features. If a composite grain size is desired, the areas of the bed occupied by different populations can be mapped, pebble counts conducted on each, and a weighted average distribution computed.
Study of the Spatial Distribution Pattern of the Digital Glacial Geomorphology in China

Based on 15 sheets of geomorphologic maps of 1∶1 000 000 published at the 1980s,digital geomorphologic database of China was integrated and built,which was interpreted from remote sensing images,digital geographic maps,digital geology maps,published geomorphologic maps et al.The area of shape genesis types of digital glacial geomorphology of China is 54.659×104 km2,and shape structure types includes point types(10 classes,2 726 entities,including glacial lake,cirque,lateral moraine bars,ancient glaciated through valley,ancient cirque firn basin,hanging valley and so on),line types(6 classes,1656 entities,including modern snow line,glaciated through valley and so on) and polygon types(2 classes,49 046 entities,including modern glaciers and lateral moraine bars) and glacial geomorphology mainly distributes in Xinjiang and Tibetan Plateau of the west of China. Firstly,whole characteristics of glacial geomorphology were analyzed from altitude,terrain relief,and basic landform types: glacial geomorphology in China mainly distributes in the extremely high altitude regions with the area of 37.608×104 km2;as to the relief amplitude,the area of large relief mountain is the maximum,which is 28.460×104 km2;reference to the basic land types,the area of large relief extremely high altitude mountains is the maximum,which is 20.025×104 km2. Secondly,based on the basic landform types,glacial geomorphology characteristics were discussed from sub-genesis according to the four large geomorphologic types,i.e.,plain,platform,hill and mountain. Thirdly,according to the distribution of major mountains in the west of China,glacial geomorphology types and distribution were presented;the area with glacial geomorphology in every mountains and plateaus is(ranking from large to small): 105 348.349 km2 in the Hengduan Mountains,95 622.042 km2 in the Gangdise Range,80 940.769 km2 in the Kunlun Mountains,65 110.973 km2 in the Himalayas,41 591.851 km2 in the Tianshan Mountains,40 709.144 km2 in the Nyainqentanglha Range,24 239.634 km2 in the Qilian Mountains,23 865.829 km2 in the Qangtang Plateau,23 198.429 km2 in the Karakorum Mountains,21 315.771 km2 in the Tanggula Range,15 705.259 km2 in the Gangri Garpo Range,7 571.939 km2 in the Altay Mountains and 1 085.661 km2 in the Altun Mountains.Comparing and analyzing the distribution and types of glacial geomorphology in these mountains and plateaus show that the most widely distributed types are large relief extremely high mountains and large relief high mountains,the least widely distributed are plain,platform and hill in the middle altitude. The research has important significance to glacial geomorphology research in China and contributes to the global climate change research.
FACTORS AFFECTING THE ADOPTION OF CRYPTOCURRENCY

The study discusses the factors which play a significant role in technological adoption. Data were collected from 342 respondents with sufficient knowledge of investing in cryptocurrency to derive authentic and reliable results. We used statistical software SPSS and SmartPLS to conduct various data tests. SPSS was used to check the missing values and the normality of the data, and it was found that there was no abnormality in the data. Also, demographic analysis was done using SPSS to characterize the respondents with gender, income, occupation, and knowledge of cryptocurrency. Smart PLS software was used for further analysis involving the measurement model and the structural model. In the measurement model, we checked validity and reliability to ensure the items of every latent variable measure their corresponding latent variable when the data is valid; data were found reliable and valid for further analysis since the result of AVE was more than 0.5 in the structural model. We used path coefficients to analyze the data and test the hypotheses. None of the hypotheses were rejected, as each p-value was less than 0.05, indicating a significant impact on the model.
Seismic attribute analysis of the Upper Morrow Sandstone and the Arbuckle Group from 3D-3C seismic data at Cutter Field, southwest Kansas

iii Acknowledgements.iv Table of contents.v List of figures and tables.vii Chapter 1: Introduction.1 Chapter 2: Theory and background.4 2.1 Body waves.4 2.2 Partitioning of energy at a boundary.6 2.3 Shear wave splitting.9 2.4 Multicomponent seismic methods.10 2.5 Seismic resolution and tuning.12 2.6 Convolutional model.16 2.7 Model-based inversion.17 Chapter 3: Seismic and well data sets.20 Chapter 4: Geologic setting.24 4.1 Cutter Field.24 4.2 Anadarko Basin.24 4.3 Arbuckle Group deposition.26 4.4 Morrow deposition.28 Chapter 5: Conventional interpretation.30 5.1 P-P well-to-seismic tie.30 5.2 P-SV frequency filtering . 34 5.3 P-SV well-to-seismic tie.37 5.4 Stratigraphic and structural interpretation.40 Chapter 6: Upper Morrow Sandstone methods and results.45 6.1 Well correlations.45 6.2 AVO modeling.51 6.3 Ray trace modeling.54 6.4 Wedge modeling.56 6.5 Amplitude analysis.60
Potential Correlation Between Self-Compassion and Bedtime Procrastination: The Mediating Role of Emotion Regulation

Purpose The present research aims to investigate the potential correlations between self-compassion and bedtime procrastination, a significant behavior related to sleep. In this research, we put forward the hypothesis that a reduction in negative affect and the implementation of adaptative emotion regulation strategies can elucidate the established connections between self-compassion and a decreased tendency for bedtime procrastination. Methods Two cross-sectional online surveys (Survey I: n=241 and Survey II: n=546) were carried out via a convenient sampling method. Prior to their inclusion, all participants underwent a thorough assessment to confirm no evidence of clinical insomnia. The study participants in both survey investigations were asked to complete various psychometric assessments, including self-compassion, positive and negative affect, and bedtime procrastination; however, the study participants in Survey II additionally underwent the administration of a cognitive reappraisal assessment. Results In Survey I, a multiple mediation analysis was conducted to examine the mediating effects of self-compassion on reducing bedtime procrastination through a reduction in negative affect. The results supported the hypothesized relationships, indicating that self-compassion had the expected mediated effects by mitigating negative affective states. However, contrary to expectations, higher positive affect did not mediate the relationship between self-compassion and reduced bedtime procrastination. The findings of Survey II were confirmed through the utilization of path analysis. Moreover, this analysis provided additional evidence to suggest that the mechanism of cognitive reappraisal could account for the observed decrease in negative affect associated with self-compassion. The present study found a notable and sustained impact of self-compassion on reducing instances of delaying bedtime activities. Conclusion The present research contributes novel empirical evidence suggesting a negative association between self-compassion and the propensity to engage in bedtime procrastination. This relationship can be attributed partly to the implementation of an adaptative emotion regulation mechanism that effectively alleviates negative affect.