Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of Transportation Services Using Service Quality Method

Transportation business people try to meet customer needs by providing the best quality service and maximum facilities so that customers feel satisfied with the services that have been provided, but the quality of services that have been provided is not solely in accordance with customer expectations and perceptions. The purpose of this research is to find out how good the level of service quality has been, it is necessary to measure the service quality between customer expectations and perceptions of the service quality. The research method used is to compare customer expectations and perceptions using the service quality gap method. 5. The research instrument is a questionnaire consisting of 25 statement variables and classifies into 5 dimensions of service quality according to Parasuraman's, namely the dimensions of tangibles, reliability, responsiveness, assurance and empathy. The overall level of customer expectations got an average score of 3.06 and the level of perception perceived by customers as a whole got an average score of 2.90. The statement with the highest gap (gap 5) and included in quadrant A (the main priority for improvement) on the Cartesian diagram is in the quality of service regarding buses facilitated by safety support (first aid kits, fire extinguishers and emergency exits), buses facilitated by entertainment support (karaoke and LCD TV) and buses are facilitated to support comfort (reclining chairs, air conditioning, blankets and pillows). The impact this research about the quality of service is not appropriate or does not meet the expectations of customers, therefore it is necessary to improve the quality of related services so that the quality of service provided is maximal and can meet customer expectations
The principle of relativity and the indeterminacy of special relativity

This work ends a trilogy devoted to a journey into the foundations of special relativity. The first paper debated the meaning of the constancy of the two-way speed of light and its close relation to the conceptualization of time. The second one addressed the question of the possible constancy of the one-way speed of light and the trivial—but, unfortunately, even now somewhat controversial—question of the compatibility between the assumption of a special system of reference and Einstein's special relativity. The present study deals with the principle of relativity. Its historical evolution is reviewed and a ‘weak’ formulation is defended. It is emphasized that many assertions usually associated with special relativity, such as the ‘relativity of time dilation’ and ‘relativity of space contraction’ are indeed philosophical statements, as it has been established already by several authors in the past. Nonetheless, most teachers and scientists still believe nowadays they are implied by the theory and by the group property of the Lorentz transformation. This is by no means so, as it is reviewed and elucidated with the simple example on space contraction. It is argued that the lack of knowledge of the true value of the one-way speed of light in empty space leaves the theory undetermined. Einstein's special relativity corresponds to a simple and very elegant solution to this problem, allowing the study of relative motion without any concern with the study of absolute motion, which is considered to be superfluous. However, its standard interpretation is minimalist and even misleading. A large number of researchers have discussed this question, mostly within the conventionality of simultaneity thesis. The typical formulation of this thesis provides some new physical insight and points out the problem, but does not solve it. In contrast, it often leads to a labyrinth of difficult language which is herein clarified.
Symmetry of the pentacene molecule and classification of electron states studied in the frame of group action on a set

Pentacene have recently become the subject of intense studies due to their physical properties which follow from the states of their outer-shell electrons that are able to take part in molecule bonding. The symmetry of these molecules provides the classification of quantum states according to the group theory method. In this paper, we apply a molecular state-space factorization scheme for the classification of pentacene molecules based on the structure of their electron states.
THE EFFECTS OF MARKER SIZE ON THE ACCURACY OF THE ARlEL PERFORMANCEANALYSIS SYSTEM (APASTM)

INTRODUCTION In order to increase the efficiency of today's motion analysis systems, most systems are capable of auto digization. In order for the APAS system to auto digitize, retroreflective markers must be used for accurate tracing of the movement. During auto digization, the computer's software will search a given area for pixels that are above a pre-determined light threshold. From these threshold pixels, the software will calculate the center of the marker. To increase the accuracy of the measurements, it has been suggested that the larger the marker, the more accurate the measurement. The purpose of this study was to examine the effects of marker size on the accuracy of the APAS system. METHODS Eight retroreflective markers were placed upon an inverted T-shaped pendulum. Tbelve reference angles were calculated from these markers. Four different starting positions were used (static, a 45 deg, a 90 deg, and a 120 deg. release position) while using four different marker sizes (0.45,0.95, 1.27, and 1.91 cm.) for a total of 16 different conditions. Ten trials were done for each condition. Tbenty frames were auto-digitized from each trial. Frame 10 represented the low point of the trajectory for the dynamic conditions. Deviations were calculated by taking the average angle over the 20 frames and subtracting it from the reference angle. The data was analyzed using a Mixed Effects ANOVA. Inter-trial variability was determined by subtracting the reconstructed angle from the reference angle on a frame by frame basis. RESULTS Significance was found in the ANOVA of marker [F (3,1893) = 6.39, p < 0.00031 and position [F (3,1893) = 350.41, p < 0.00011. Contrast tests indicate that markers 1-3 were all statistically different from marker 4 (p < 0.001, p < 0.0003, p < 0.0106). The least square means of marker showed that as the marker size increased the deviation on average decreased (0.4339 deg. to 0.3883 deg.). Examination of the inter-trial variability showed that the variability increased from the static position up to the 120 deg. position. CONCLUSION Marker size was shown to have a significant effect upon the accuracy of the APAS system. Examination of the least square means seems to indicate that the smallest marker size had the most error and the largest marker size had the least error. It should be noted though that regardless of marker size the error was no greater than 0.5 degrees. For most motion analysis procedures an error of this magnitude is probably an acceptable error.
A longitudinal study reveals persistence of antimicrobial resistance on livestock farms is not due to antimicrobial usage alone

Introduction There are concerns that antimicrobial usage (AMU) is driving an increase in multi-drug resistant (MDR) bacteria so treatment of microbial infections is becoming harder in humans and animals. The aim of this study was to evaluate factors, including usage, that affect antimicrobial resistance (AMR) on farm over time. Methods A population of 14 cattle, sheep and pig farms within a defined area of England were sampled three times over a year to collect data on AMR in faecal Enterobacterales flora; AMU; and husbandry or management practices. Ten pooled samples were collected at each visit, with each comprising of 10 pinches of fresh faeces. Up to 14 isolates per visit were whole genome sequenced to determine presence of AMR genes. Results Sheep farms had very low AMU in comparison to the other species and very few sheep isolates were genotypically resistant at any time point. AMR genes were detected persistently across pig farms at all visits, even on farms with low AMU, whereas AMR bacteria was consistently lower on cattle farms than pigs, even for those with comparably high AMU. MDR bacteria was also more commonly detected on pig farms than any other livestock species. Discussion The results may be explained by a complex combination of factors on pig farms including historic AMU; co-selection of AMR bacteria; variation in amounts of antimicrobials used between visits; potential persistence in environmental reservoirs of AMR bacteria; or importation of pigs with AMR microbiota from supplying farms. Pig farms may also be at increased risk of AMR due to the greater use of oral routes of group antimicrobial treatment, which were less targeted than cattle treatments; the latter mostly administered to individual animals. Also, farms which exhibited either increasing or decreasing trends of AMR across the study did not have corresponding trends in their AMU. Therefore, our results suggest that factors other than AMU on individual farms are important for persistence of AMR bacteria on farms, which may be operating at the farm and livestock species level.
Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder

CDKL5 (cyclin-dependent kinase-like 5) deficiency disorder (CDD) is a severe neurodevelopmental disease that mostly affects girls, who are heterozygous for mutations in the X-linked CDKL5 gene. Mutations in the CDKL5 gene lead to a lack of CDKL5 protein expression or function and cause numerous clinical features, including early-onset seizures, marked hypotonia, autistic features, gastrointestinal problems, and severe neurodevelopmental impairment. Mouse models of CDD recapitulate several aspects of CDD symptomology, including cognitive impairments, motor deficits, and autistic-like features, and have been useful to dissect the role of CDKL5 in brain development and function. However, our current knowledge of the function of CDKL5 in other organs/tissues besides the brain is still quite limited, reducing the possibility of broad-spectrum interventions. Here, for the first time, we report the presence of cardiac function/structure alterations in heterozygous Cdkl5 +/− female mice. We found a prolonged QT interval (corrected for the heart rate, QTc) and increased heart rate in Cdkl5 +/− mice. These changes correlate with a marked decrease in parasympathetic activity to the heart and in the expression of the Scn5a and Hcn4 voltage-gated channels. Interestingly, Cdkl5 +/− hearts showed increased fibrosis, altered gap junction organization and connexin-43 expression, mitochondrial dysfunction, and increased ROS production. Together, these findings not only contribute to our understanding of the role of CDKL5 in heart structure/function but also document a novel preclinical phenotype for future therapeutic investigation.
Height dependence of the observed spectrum of radar backscatter from HF‐induced ionospheric Langmuir turbulence

Observations of the spectrum of 430-MHz radar backscatter from HF-induced Langmuir turbulence with height discrimination are described. During very stable ionospheric conditions under which the height of the below-threshold backscatter spectrum had changed by less than 300 m during a 7-min period, a 20-s-long temporary increase in the HF power from 3 MW ERP to 38 MW equivalent radiated HF power resulted in subsequent strong above-threshold spectra extending to heights up to 1200 m greater than the height of the below-threshold spectrum for more than a minute. The generation of irregularities in the plasma density during the 20 s of enhanced HF power is suggested as a possible cause of this persistence of strong above-threshold spectra at greater heights. The initial temporal evolution of the backscatter spectrum from Langmuir turbulence after the start of HF transmissions was observed for different heights. The observational results are compared with the predictions of existing theories of Langmuir turbulence.
Factor VII Activating Protease (FSAP) and Its Importance in Hemostasis—Part I: FSAP Structure, Synthesis and Activity Regulation: A Narrative Review

Factor VII activating protease (FSAP) was first isolated from human plasma less than 30 years ago. Since then, many research groups have described the biological properties of this protease and its role in hemostasis and other processes in humans and other animals. With the progress of knowledge about the structure of FSAP, several of its relationships with other proteins or chemical compounds that may modulate its activity have been explained. These mutual axes are described in the present narrative review. The first part of our series of manuscripts on FSAP describes the structure of this protein and the processes leading to the enhancement and inhibition of its activities. The following parts, II and III, concern the role of FSAP in hemostasis and in the pathophysiology of human diseases, with particular emphasis on cardiovascular diseases.
Grievance-fueled sexual violence

The grievance fueled violence paradigm encompasses various forms of targeted violence but has not yet been extended to the theoretical discussion of sexual violence. In this article, we argue that a wide range of sexual offenses can be usefully conceptualized as forms of grievance fueled violence. Indeed, our assertion that sexual violence is often grievance fueled is unoriginal. More than 40 years of sexual offending research has discussed the pseudosexual nature of much sexual offending, and themes of anger, power, and control – themes that draw clear parallels to the grievance fueled violence paradigm. Therefore, we consider the opportunities for theoretical and practical advancement through the merging of ideas and concepts from the two fields. We examine the scope of grievance in the context of understanding sexual violence, and we look to the role of grievance in the trajectory toward both sexual and nonsexual violence, as well as factors that might distinguish grievance fueled sexual from nonsexual violence. Finally, we discuss future research directions and make recommendations for clinical practice. Specifically, we suggest that grievance represents a promising treatment target where risk is identified for both sexual and nonsexual violence.
Relationship of blood heavy metals and osteoporosis among the middle-aged and elderly adults: A secondary analysis from NHANES 2013 to 2014 and 2017 to 2018

Objective This study aimed to assess the relationship between blood heavy metals and a higher prevalence of osteoporosis in middle-aged and elderly US adults using the National Health and Nutritional Examination Surveys (NHANES). Methods The secondary data analysis was performed using the data of NHANES 2013–2014 and 2017–2018. We used the information, including physical examination, laboratory tests, questionnaires, and interviews, provided by participants in NHANES. Logistic regression and weighted quantile sum (WQS) regression models were used to explore the relationships between levels of blood heavy metals and a higher prevalence of osteoporosis. Results A total of 1,777 middle-aged and elderly participants were analyzed in this study, comprising 115 participants with osteoporosis and 1,662 without osteoporosis. Adjusted model 1 showed a significant positive relationship between cadmium (Cd) levels and a higher prevalence of osteoporosis (quartile 2, OR = 7.62; 95% CI, 2.01–29.03; p = 0.003; quartile 3, OR = 12.38; 95% CI, 3.88–39.60; p < 0.001; and quartile 4, OR = 15.64; 95% CI, 3.22–76.08; p = 0.001). The fourth quartile of selenium (Se) level (OR = 0.34; 95% CI, 0.14–0.39; p < 0.001) led to a lower prevalence of osteoporosis and exerted a protective effect on model 1. Other models produced similar results to those of model 1. A subgroup analysis showed that Cd levels were positively related to a higher prevalence of osteoporosis in all three models in women, while this relationship was not found in men. The fourth quartile of the Se level was related to a lower prevalence of osteoporosis in both male and female analyses. A significant positive relationship was found between the blood Cd level and a higher prevalence of osteoporosis in the non-smoking subgroup. Blood Se level showed a protective effect on the fourth quartile in both the smoking and non-smoking subgroups. Conclusion Blood Cd level aggravated the prevalence of osteoporosis, while blood Se level could be a protective factor in osteoporosis among the US middle-aged and older populations.
Alliance A031902 (CASPAR): A randomized phase (ph) 3 trial of enzalutamide with rucaparib/placebo in first-line metastatic castration-resistant prostate cancer (mCRPC).

TPS277 Background: Despite a growing number of treatment options for first-line mCRPC, approximately 40% of patients (pts) have radiographic progression within the first year. Co-inhibition of androgen receptor (AR) and PARP is a promising therapeutic strategy that leverages synthetic lethality induced by impaired double-strand DNA repair. Two phase III studies have shown improvement in radiographic progression-free survival (rPFS) in HRR-mutant pts with abiraterone + PARPi combinations vs abiraterone alone. However, the results in HRR-wild type pts are conflicting, with only one of the studies demonstrating a benefit with the abiraterone + PARPi combination. ENZ + RUCA has shown an acceptable safety profile & no significant drug-drug interactions (S-DDI) in a phase 1b trial. This allows its evaluation in mCRPC. Methods: CASPAR (A031902) is a phase 3 study in which 984 pts will be randomized on a 1:1 basis to ENZ plus RUCA/PBO. HRR gene aberration is not required for enrollment. All pts will undergo next-generation targeted exome sequencing from archival tumor tissue (new biopsy only required if no archival tissue is available). Treatment will be continued until disease progression and crossover is not allowed. Key eligibility criteria are age ≥ 18 years, ECOG PS 0-2, biopsy-proven prostate adenocarcinoma, progressive (PSA or radiographic) disease per Prostate Cancer Working Group 3 guidelines, measurable or non-measurable disease per RECIST 1.1, no prior treatment for mCRPC (prior docetaxel, abiraterone, darolutamide, or apalutamide in non-mCRPC setting is allowed), no significant uncontrolled comorbidity, and no medications with S-DDI with ENZ/RUCA. Hierarchical co-primary endpoints are overall survival (OS) and rPFS. The OS analysis will be undertaken as a primary endpoint if the rPFS endpoint is met. For a one-sided logrank test with a type 1 error rate equal to 0.025, the study has 90% power to detect a hazard ratio (HR) of 0.71 in rPFS (median rPFS of 15 and 21 months in control and combination arms, respectively), and 80% power to detect an HR of 0.80 in OS (median OS of 32 and 40 months, respectively). Key secondary endpoints are rPFS and OS in pts with vs without pathogenic BRCA1, BRCA2, or PALB2 alterations; and differences in adverse events and quality of life (QOL) outcomes between the treatment arms. QOL assessments include Functional Assessment of Cancer Therapy–Prostate (FACT-P), Brief Pain Inventory Short Form (BPI-SF), and EQ-5D-5L. A key correlative endpoint is the sensitivity of ctDNA testing for HRR gene alterations. Enrollment began in July 2021 & the study is available for participation to all US-NCTN sites. Clinical trial information: NCT04455750 .
A Theoretical and Experimental Study of the Enthalpies of Formation of LaNi5-Type Compounds

The heats of formation of LaNi5-type compounds are computed within a tight-binding scheme for the d-band. It is shown that the relatively large difference between the energy levels of the two elements is a dominant factor in the determination of the formation energy. The evolution of the energy level of the rare-earth metal can explain the experimental behaviour of the heats of formation of the RNi5 compounds along the rare-earth series. In order to discuss the calculated results the enthalpies of formation of LaNi5, PrNi5, SmNi5, and YNi5 are determined by a calorimetric method. Die Bildungswarmen von LaNi5-Verbindungen werden numerisch innerhalb eines “tight-binding”-Modells fur das d-Band berechnet. Es wird gezeigt, das die relativ grose Differenz zwischen den Energieniveaus der beiden Elemente ein dominierender Faktor bei der Bestimmung der Bildungs-energie ist. Die Entwicklung des Energieniveaus des Seltenerd-Metalls kann das experimentelle Verhalten der Bildungswarmen der RNi5-Verbindungen in der Serie der Seltenen Erden erklaren. Um die berechneten Ergebnisse zu diskutieren, werden die Bildungsenthalpien von LaNi5, PrNi5, SmNi5 und YNi5 mittels kalorimetrischen Methoden bestimmt.
Preparation and encapsulation efficiency of surface modified egg albumin nanoparticles

: A biocompatible nano-drug delivery vehicle can efficiently deliver the toxic drug to the targeted site in nano-quantity to treat cancer patients. Considering this, the current study aims to fabricate stable egg albumin nanoparticles by using chloroacetic acid to modify their surfaces. The carboxyl functionalized egg albumin (FEA) nanoparticles were prepared through the desolvation process using ethanol as the desolvating agent; the generated nanoparticles were stabilized by glutaraldehyde. To obtain stable nanoparticles of suitable size, various reaction parameters viz concentration of FEA, pH, agitation speed, glutaraldehyde concentration, and rate of ethanol addition were examined. In neutral and alkaline mediums, we can get nanoparticles of 120-160 nm with -32 mV zeta potential. The pH of the medium played a decisive role, which strongly influences the FEA particle diameter and surface charge, while other parameters show little influence. SEM monochrome image of functionalized EA nanoparticles also supported the particle size of around 130 nm. Gallic acid (GA) has been encapsulated under optimal desolvation conditions using the FEA/GA acid ratios of 1:1, 2:1, 4:1, and 8:1. The obtained GA entrapped FEA spherical nanoparticles (GA-FEA) had a -30.9mV zeta potential and were negatively charged. At a 2:1 polymer/drug ratio, an entrapment efficiency (EE) of 90.4 % (w/w) and drug loading capacity of about 28.7 % (w/w) were achieved. This work is beneficial to the scientists involved in the field of cancer research.
Temporally Unfolding Neural Representation of Pictorial

The human visual system possesses a remark- ableabilityto reconstructtheshapeofanobjectthatispartly occluded by an interposed surface. Behavioral results sug- gest that, under some circumstances, this perceptual process (termed amodal completion) progresses from an initial representation of local image features to a completed representation of a shape that may include features that are not explicitly present in the retinal image. Recent functional magnetic resonance imaging (fMRI) studies have shown that the completed surface is represented in early visual cortical areas. We used fMRI adaptation, combined with brief, masked exposures, to track the amodal comple- tion process as it unfolds in early visual cortical regions. We report evidence for an evolution of the neural representation from the image-based feature representation to the com- pleted representation. Our method offers the possibility of measuringchangesincorticalactivityusingfMRIoveratime scale of a few hundred milliseconds.
Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine?

Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed to study pancreatic cancer biology, progression, and treatment response, filling the translational gap between in vitro and in vivo models. Here, we review the rapidly evolving field of PDAC organoids and their potential as powerful preclinical tools that could pave the way towards precision medicine for pancreatic cancer.