Miracle-dz/UniFAR-FTUs huggingface dataset:
Explore How Online Healthcare Can Influence Willingness to Seek Offline Care

With the recent development of internet healthcare, many hospitals have laid out their online platforms. However, there have been some poor service levels and low quality. The frequency of such problems has led to a decline in patient satisfaction. Therefore, it is vital to explore how hospitals can improve user satisfaction and willingness to visit them offline by setting up an online presence. Most studies conducted so far have remained limited to the single dimension of online or offline healthcare, with few studies exploring the relationship between them. While a few studies have explored the impact of online service quality on willingness to seek offline care, they also face the problem of a single perspective of analysis. Therefore, this study constructs a multidimensional model of the factors influencing online healthcare users’ willingness to seek offline care by integrating the value-based adoption model and the stimulus–organism–response model. Through a partial least squares-structural equation modelling analysis of 283 valid samples, this study found that online doctor–patient interactions and service quality positively impact user perception. This paper explores the development path of online healthcare from a new theoretical perspective. In addition, the findings provide new guidelines for hospitals to achieve economic and social benefits.
Maternal and Perinatal Outcomes of COVID-19-Positive Pregnant Women

Background The risks of adverse maternal and perinatal outcomes are not very clear in coronavirus disease 2019 (COVID-19)-positive pregnant women. Therefore, this study aimed to determine the maternal and fetal outcomes in COVID-19-positive pregnancies. Methodology This prospective, cohort study was conducted in a tertiary care center over the period of one year. The study group comprised pregnant patients who presented with COVID-19 in the first and second waves of the pandemic. Maternal symptoms due to COVID-19 infection, comorbidities, number of admissions to the intensive care unit (ICU), and maternal mortality were noted for every patient. Perinatal outcomes were recorded in the form of intrauterine growth retardation (IUGR), mode of delivery, preterm deliveries, birth weight of newborns, neonatal intensive care unit (NICU) admissions, and neonatal mortality. Data analysis was done in the form of a variable percentage and mean ± standard deviation (SD). Results COVID-19-positive pregnant patients were mostly asymptomatic (48.07%). Term deliveries (37-40 weeks) were seen in 44 (89.8%) patients. The percentage of normal vaginal delivery was 74% and cesarean section was 24%. Out of 52 patients, two (3.8%) patients were admitted to the high dependency unit (HDU), one (1.9%) patient was admitted to the ICU, and 49 (94.3%) patients were in the isolation ward. Of the 49 live births, four (8.16%) newborns were admitted to the NICU. No neonatal death was recorded. Conclusions In this study, COVID-19-pregnant women were mostly asymptomatic. Neonates of COVID-19-infected women also mostly tested COVID-19 negative. More studies are needed with larger sample sizes to determine the effect of COVID-19 infection in pregnant women and neonates.
Assessment of macular function in dense cataract using Maddox rod

Cataract is a leading cause of blindness worldwide. However there is surgical option available for treatment with complete cure in majority of patients. For dense cataract Maddox Rod was evaluated. A total of 200 patients were recruited. Maddox Rod test for macular function appears to be useful in a great majority of patients. The assessment of macular function in dense cataract is difficult but the Psycho physiological test like Maddox rod test was found to be the reliable in patients with cataract and its quick and understandable
Association of Insomnia with Comorbidities among Patients Visiting Tertiary Care Hospitals Lahore

Insomnia is a condition that affects an individual by inability to get sufficient quality sleep or problem in maintaining sleep that is important for healthy functioning, performance and wellbeing. There is very scarce data regarding insomnia and its relation with different diseases. The present study was aimed to find out the association of insomnia with comorbidities among patients visiting Tertiary Care Hospitals, Lahore. A cross sectional study was conducted from May 2019 to September 2019 in Tertiary Care Hospitals district Lahore. Interviews were conducted by researchers to collect data through Pre-Tested Questionnaire. Informed consent was first taken from all participants. Data were analyzed by using Chi-square to find out the association of insomnia with comorbidities through SPSS version 25.0. Thousand (n=1000) patients suffering from different diseases randomly selected to participate, of which 43.6% were male and 56.4% were female. Results of present study revealed that association of insomnia with the diseases such as cardiovascular diseases (p=0.05), diabetes mellitus m(p=0.001), gastrointestinal problems (p=0.034), premenstrual syndrome (p=0.00), joint pains (p=0.01) and prostate cancer (p=0.01) was found to be significant. While an insignificant association of insomnia was noticed with hypertension (p=0.850), hearing impairments (p=1.22), COPD (p=0.288). It was concluded that insomnia was most commonly present in the patients of cardiovascular diseases, diabetes mellitus, premenstrual syndrome, gastro-intestinal problems, joint pains and prostate cancer.
The origin of Patagonia: insights from Permian to Middle Triassic magmatism of the North Patagonian Massif

Abstract We conducted a U–Pb–Hf isotope study on zircon crystals from ignimbrites of the Changhsingian to Olenekian (253–248 Ma) Los Menucos Basin in the North Patagonian Massif (NPM), Argentina, in order to evaluate the age and petrogenesis of the magmas. Additionally, a compilation of whole-rock geochemistry and U–Pb–Hf in zircon isotope data for the Permian to Middle Triassic rocks of the NPM, for comparison with our data, was made to assess whether Patagonia would have been an exotic terrane accreted to SW Gondwana during the late Palaeozoic. We interpret the available U–Pb–Hf data to suggest that northern Patagonia experienced eastward arc expansion from the early Permian, about 273 Ma ago. This ∼820 km arc expansion event involved crustal shortening and magmatism with high-silica adakitic affinity, resulting in Hf-isotopic pull-down. At 253 Ma, slab steepening became associated with the coeval emplacement of ignimbrites of the Los Menucos Basin, which involved post-orogenic to intraplate magmatism. During the Middle Triassic, a slab break-off triggered uplift and basaltic underplating, promoting the emplacement of dike swarms with C-type adakitic signature at 246–244 Ma. The Hf isotope data for SW Gondwana for the same period indicate distinct trends that are explained here by differential slab roll-back since the Guadalupian, in a slab-tearing setting. Therefore, Permian to Middle Triassic magmatism is interpreted as having been associated with an eastward-directed proto-Pacific subduction system, which ultimately supports an autochthonous origin for Patagonia.
Money matters: teachers in the public and private sectors

Abstract The public personnel system, particularly the compensation system, has long faced many criticisms such as inflexibility and un-competitiveness when compared to other sectors. This is especially true for compensation systems for K-12 teachers, who also care about public service values, even if they work in the non-public sectors. We examine wage competition for teachers between the three K-12 sectors within metropolitan market areas, even with controls for many other variables. While the public sector is clearly the dominant (but not monopsonist) buyer, it also responds to wage competitions from the other two sectors.
Voltage difference transresistance amplifier and its application: floating FDNR simulator circuit

ABSTRACT In this article, a new active building component with electronically tunable transresistive block, voltage difference transresistance amplifier, and its floating frequency dependent negative resistor simulator circuit application is presented. The simulator circuit is shown to operate using single active building block with two grounded passive components, to be electronically tunable over its value which is controlled by an independent current source, not to require any conditions of component matching and to have good sensitivity performance with respect to tracking errors. To examine functionality of the design, a CRD band-pass filter example is given. Numerous simulation program with integrated circuit emphasis (SPICE) simulations are performed and depicted through the article to verify validity of the study. Taiwan semiconductor manufacturing company (TSMC) 0.18 µm complementary metal oxide semiconductor technology parameters are used through simulations.
Haptic-enhanced learning in preclinical operative dentistry

Background: Virtual reality haptic simulators represent a new paradigm in dental education that may potentially impact the rate and efficiency of basic skill acquisition, as well as pedagogically influence the various aspects of students’ preclinical experience. However, the evidence to support their efficiency and inform their implementation is still limited. Objectives: This thesis set out to empirically examine how haptic VR simulator (Simodont®) can enhance the preclinical dental education experience particularly in the context of operative dentistry. We specify 4 distinct research themes to explore, namely: simulator validity (face, content and predictive), human factors in 3D stereoscopic display, motor skill acquisition, and curriculum integration. Methods: Chapter 3 explores the face and content validity of Simodont® haptic dental simulator among a group of postgraduate dental students. Chapter 4 examines the predictive utility of Simodont® in predicting subsequent preclinical and clinical performance. The results indicate the potential utility of the simulator in predicting future clinical dental performance among undergraduate students. Chapter 5 investigates the role of stereopsis in dentistry from two different perspectives via two studies. Chapter 6 explores the effect of qualitatively different types of pedagogical feedback on the training, transfer and retention of basic manual dexterity dental skills. The results indicate that the acquisition and retention of basic dental motor skills in novice trainees is best optimised through a combination of instructor and visualdisplay VR-driven feedback. A pedagogical model for integration of haptic dental simulator into the dental curriculum has been proposed in Chapter 7. Conclusion: The findings from this thesis provide new insights into the utility of the haptic virtual reality simulator in undergraduate preclinical dental education. Haptic simulators have promising potential as a pedagogical tool in undergraduate dentistry that complements the existing simulation methods. Integration of haptic VR simulators into the dental curriculum has to be informed by sound pedagogical principles and mapped into specific learning objectives.
Low-Dose Resveratrol Inhibits RIPK3-Mediated Necroptosis and Delays the Onset of Age-Related Hearing Loss

Background: To investigate the pathophysiology of age-related hearing loss (ARHL) and the mechanism of resveratrol (RSV) in prevention and treatment of ARHL. Methods: C57BL/6 mice of different ages were used in this study. Auditory brainstem response (ABR) was performed to assess hearing and identify abnormalities. Surface preparation and hair cell-specific marker Myo VIIa were employed to evaluated cochlear hair cell losses. Scanning electron microscopy (SEM) was to observe the microstructure of the organ of Corti (OC). The expression of related proteins in the RIPK1/RIPK3/MLKL pathway in cochlear tissue was detected by immunofluorescence. Results: In old mice (15 months), the ABR threshold increased significantly compared with the young mice. After 50 mg/kg RSV intervention, the hearing threshold of the old mice was significantly reduced at 8 kHz and 12 kHz as well as click. 100 mg/kg RSV led to a statistically significant reduction in hearing threshold only at clicks, whereas 300 mg/kg RSV showed no difference at all frequencies tested. In terms of cochlear hair cell loss, the damage of OHC and IHC was severe in old mice, but the damage was evidently reduced in RSV 50 mg/kg group. Notably, in the RSV 300 mg/kg group, the loss and disorientation of both the OHCs and IHCs were aggravated. Under SEM, a large number of OHCs were lost in the old group, but increased significantly in the RSV 50 mg/kg group, and even the OHCs were more seriously damaged in the RSV 300 mg/kg group. Furthermore, immunofluorescence showed that 50 mg/kg RSV significantly reduced the expression of RIPK3, RIPK1, and MLKL in the cochlea during aging, especially in necroptosis-sensitive regions OCs and SGN. Conclusion: Low-dose RSV inhibited RIPK3-mediated necroptosis in aging cochlea and delayed the onset of ARHL, which was a promising therapeutic strategy for ARHL.
Investor sentiment and the MAX effect: evidence from Korea

ABSTRACT Stocks with extreme positive returns underperform the market since they are overpriced due to investors’ preference towards lottery-like stocks, stocks with a low probability of an extremely high payoff. Using data from the South Korean stock market, we show that the underperformance of such stocks is pronounced following periods of low investor sentiment. This suggests that low investor sentiment coincides with economic downturn when stocks with extreme positive returns experience increased salience and attention. We provide supporting evidence that stocks with extreme positive returns experience a substantial increase in trading volume and buying pressure from individual investors when investor sentiment is low.
Contribution of HRD Practices on Employees’ Commitment: An Observation of Development Banks in Nepal

The dynamics of business environment always poses sever new issues that need to be consider by an organization to be competitive in the business. The human resource development practices can be an instrument to meet this prerequisite. Considering this fact, this study aimed to examine the contribution of HRD practices on the commitment of employees in Nepalese development banks. For this, 320 bankers as respondents are selected from national level development banks with head office based on Kathmandu valley to meet the study objectives. Structured questionnaire as an instrument for data collection based on 5-point Likert scale has been applied. The data are processed and analyzed with use of MS-Excel, SPSS, descriptive, correlation and regression analysis. The findings shows that HRD dimensions has significant positive association and impact on commitment of employees in Nepalese development banks. However, integrated HRD strategies still need to be considered by the development banks for its own effectiveness as exposed by the respondents. Thus, the researchers concludes that HRD practices to make their employees more dedicated and committed as per the dynamics of market then development banks of Nepal should be considered integrated HRD practice as a core value of their banks. Therefore, it is recommended that stakeholders specially executives of banks to put keen attention for framing a suitable HRD strategy for remain competitive.
Remote iVR for Nutrition Education: From Design to Evaluation

While different crowdsourcing platforms promote remote data collection, experiments in the immersive Virtual Reality (iVR) research community are predominantly performed in person. The COVID-19 pandemic, however, has forced researchers in different disciplines, including iVR, to seriously consider remote studies. In this paper, we present a remote study using the Immersive Virtual Alimentation and Nutrition (IVAN) application, designed to educate users about food-energy density and portion size control. We report on the results of a remote experiment with 45 users using the IVAN app. In IVAN, users actively construct knowledge about energy density by manipulating virtual food items, and explore the concept of portion size control through hypothesis testing and assembling virtual meals in iVR. To explore the feasibility of conducting remote iVR studies using an interactive health-related application for nutrition education, two conditions were devised (interactive vs. passive). The results demonstrate the feasibility of conducting remote iVR studies using health-related applications. Furthermore, the results also indicate that regardless of level of interactivity learners significantly improved their knowledge about portion size control after using the IVAN (p < 0.0001). Adding interactivity, however, suggests that the perceived learning experience of users could be partially affected. Learners reported significantly higher scores for immediacy of control in the interactive condition compared to those in the passive condition (p < 0.05). This study demonstrates the feasibility of conducting an unsupervised remote iVR experiment using a complex and interactive health-related iVR app.
The Role and Interactions of Programmed Cell Death 4 and its Regulation by microRNA in Transformed Cells of the Gastrointestinal Tract

Data from GLOBOCAN 2020 estimates that there were 19.3 million new cases of cancer and 10.0 million cancer-related deaths in 2020 and that this is predicted to increase by 47% in 2040. The combined burden of cancers of the gastrointestinal (GI) tract, including oesophageal-, gastric- and colorectal cancers, resulted in 22.6% of the cancer-related deaths in 2020 and 18.7% of new diagnosed cases. Understanding the aetiology of GI tract cancers should have a major impact on future therapies and lessen this substantial burden of disease. Many cancers of the GI tract have suppression of the tumour suppressor Programmed Cell Death 4 (PDCD4) and this has been linked to the expression of microRNAs which bind to the untranslated region of PDCD4 mRNA and either inhibit translation or target the mRNA for degradation. This review highlights the properties of PDCD4 and documents the evidence for the regulation of PDCD4 expression by microRNAs in cancers of the GI tract.
An Antimicrobial Treatment Assessment of Serratia marcescens Bacteremia and Endocarditis

We assessed the treatment of Serratia marcescens bacteremia and endocarditis in one of the largest single center studies. We could not identify an advantage with any particular antibiotic treatment regimen in this study. Induction of AmpC or selection of ESBL organisms was not displayed by any of the organisms.
Diagnostic-Therapeutic Pathway and Outcomes of Early Stage NSCLC: a Focus on EGFR Testing in the Real-World

Background Osimertinib is considered the standard-of-care for previously-untreated EGFR mutant advanced non-small cell lung cancer (NSCLC). Oncogene driver screening in early NSCLC is not standard practice. A real-world study has been designed in order to investigate the optimal testing frequency and timing for EGFR mutations in early NSCLC in clinical practice. Patients and Methods The present observational, retrospective study evaluated the real-world diagnostic-therapeutic pathway and clinical outcomes of 225 patients with stage I-III NSCLC, with particular reference to the EGFR-mutant subgroup. Results Prior to surgery, 101 patients had undergone a diagnostic biopsy; EGFR mutational analysis was available in 56 (55%) patients and 12 patients (21%) had a cancer harboring an EGFR mutation. Among surgical specimens, reflex EGFR test was performed in 181 (80%) of 225 and 35 cases (19%) were EGFR mutant. The majority of patients had not received adjuvant chemotherapy (N=174, 77%) or adjuvant radiotherapy (N=201, 89%). Of 49 (22%) patients experiencing disease relapse, 26 (53%) received first-line systemic treatment. All EGFR-mutant relapsed patients (N=6, 12.2%) received an EGFR-TKI. Median overall survival (OS) and relapse-free survival for the entire population were not reached. Multivariate analysis for OS confirmed a significant correlation with age, female gender, EGFR status, necrosis score, perineural invasion, and relapsed disease. EGFR test costs represented 1.6-2.4% of the total costs of management per patient (€34,340). Conclusions Our results suggest that the frequency of EGFR mutations in early stage (I-III) NSCLC is similar to that of advanced stages. Reflex EGFR testing in all early-stage NSCLC at diagnosis or after surgery appears to be a valid tool to give patients the chance to benefit from targeted adjuvant treatment.
Media Report About Climate Change in an English Online Malaysian Newspaper Through Thematic and Discourse Analysis Approaches

Climate change studies are mainly focused on disaster management and inundated with scientific jargons that the public could not fathom. Thus, the dissemination of climate change discourse to the public has been less effective due to lack of information and understanding which explains the lack of public engagement and participation. Studies on climate change that consider linguistics aspects are beginning to emerge, but are still lacking. Therefore, the present study intends to conduct a linguistic analysis by identifying themes in news on climate change and by analysing the extent of media propagation about climate change. 922 news articles from Malaysiakini were analysed using a corpus-driven approach through frequency and collocation analysis. This enabled us to identify themes on climate change. Discourse analysis was then conducted to find out about the linguistic manifestations of the identified themes. The findings reveal that governance is the most propagated theme, followed by mitigation and adaptation, contributor and impacts
Telemonitoring as a strategy for the intervention of occupational therapy of children and adolescents with autistic spectrum disorders in the pandemic context

Abstract Introduction Occupational Therapy has acted from the perspective of the subjects' daily lives and their ways of living, given the transformations, impacts, and consequences generated by the pandemic of COVID-19. Among the possibilities of work of the occupational therapist, there is telemonitoring. Objective To report an experience of a university extension project regarding the telemonitoring of children and adolescents with Autistic Spectrum Disorder (ASD) and their families. Method The project team is composed of a teacher from Occupational Therapy Department, and graduate and undergraduate students. A survey of the demands and interests of the families was carried out, and thirteen children and two teenagers were subsequently selected for telemonitoring actions. Results The interventions are aimed at an organization of daily life, routine, and family orientation. It is pointed out that the care offered was not restricted to the family nucleus, so regular monitoring and support for school teams were also carried out. Conclusion Telemonitoring enabled the continuity of care, as well as support for the care network, promoting a welcoming, qualified listening and guidance, based on what has been proposed by the care guidelines and public policies.