Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2α and AP-2γ Transcription Factors in Bladder Cancer

Following the invention of high-throughput sequencing, cancer research focused on investigating disease-related alterations, often inadvertently omitting tumor heterogeneity. This research was intended to limit the impact of heterogeneity on conclusions related to WWOX/AP-2α/AP-2γ in bladder cancer which differently influenced carcinogenesis. The study examined the signaling pathways regulated by WWOX-dependent AP-2 targets in cell lines as biological replicates using high-throughput sequencing. RT-112, HT-1376 and CAL-29 cell lines were subjected to two stable lentiviral transductions. Following CAGE-seq and differential expression analysis, the most important genes were identified and functionally annotated. Western blot was performed to validate the selected observations. The role of genes in biological processes was assessed and networks were visualized. Ultimately, principal component analysis was performed. The studied genes were found to be implicated in MAPK, Wnt, Ras, PI3K-Akt or Rap1 signaling. Data from pathways were collected, explaining the differences/similarities between phenotypes. FGFR3, STAT6, EFNA1, GSK3B, PIK3CB and SOS1 were successfully validated at the protein level. Afterwards, a definitive network was built using 173 genes. Principal component analysis revealed that the various expression of these genes explains the phenotypes. In conclusion, the current study certified that the signaling pathways regulated by WWOX and AP-2α have more in common than that regulated by AP-2γ. This is because WWOX acts as an EMT inhibitor, AP-2γ as an EMT enhancer while AP-2α as a MET inducer. Therefore, the relevance of AP-2γ in targeted therapy is now more evident. Some of the differently regulated genes can find application in bladder cancer treatment.
Role of the Long Intergenic Non-Protein-Coding RNA 1278/miR-185-5p/Cystatin SN Axis in Laryngeal Cancer Cells

Laryngeal cancer accounts for 25%–30% of tumors in the head and neck. Cystatin SN (CST1) was revealed to show upregulated expression in this cancer, while its functions and upstream pathway remain unknown and need investigation. The current study was designed to solve this problem. We designed short hairpin RNAs targeting CST1 for the loss-of-function assays to probe the influences of CST1 in laryngeal cancer cell proliferation and motility. The upstream competitive endogenous RNA pattern of CST1 was searched using bioinformatics analysis and confirmed by luciferase reporter assays. The experimental results demonstrated that CST1 is a tumor facilitator in laryngeal cancer by stimulating cellular proliferative, migrative, and invasive abilities. CST1 is regulated by the long intergenic non-protein-coding RNA 1278 (LINC01278)/miR-185-5p axis. LINC01278 knockdown and miR-185-5p overexpression exert the same functions as CST1 knockdown to repress cancer cell proliferation, migration, and invasion. In conclusion, LINC01278 plays an oncogenic role in laryngeal cancer by suppressing miR-185-5p to enhance CST1 expression, which enriches the molecular mechanism for the carcinogenesis of laryngeal cancer.
African Trypanosomiasis Surface Glycoprotein Molecules to T Cells in Processing and Presentation of Variant

Th1 cell responses to the variant surface glycoprotein (VSG) of African trypanosomes play a critical role in controlling infection through the production of IFN- (cid:1) , but the role of APCs in the induction and regulation of T cell-mediated protection is poorly understood. In this study, we have investigated the Ag presentation capabilities of dendritic cells (DCs) and macrophages during early trypanosome infection in relatively resistant responder and susceptible nonresponder mouse strains. Splenic DCs appeared to be the primary cell responsible for activating naive VSG-speciﬁc Th cell responses in resistant responder animals through the coordinated up-regulation of costimulatory molecules, secretion of IL-12, and presentation of VSG peptides to T cells in vivo. Splenic DC depletion and the down-regulation of costimulatory markers on splenic macrophages were observed in susceptible animals and may be associated with the inability of these animals to elicit a signiﬁcant VSG-speciﬁc T cell response. In contrast to splenic APCs, peritoneal macrophages secreted NO, failed to activate naive Th cells in vitro, and presented relatively low levels of VSG peptides to T cells in vivo. Thus, VSG-speciﬁc Th1 cell responses may be determined by tissue- and cell-speciﬁc differences in Ag presentation. Additionally, all APCs from resistant and susceptible strains displayed a reduced ability to process and present newly encountered exogenous Ag, including new VSG molecules, during high parasitemia. Thus, initial uptake of VSG (or other trypanosome factors) may interfere with Ag presentation and have dramatic consequences for subsequent T cell responses to other proteins. The Journal of Immunology, 2009, 183: 3344–3355.
Insights and Opportunities for HCI Research into Hurricane Risk Communication

Communicating risk to the public in the lead-up to tropical storms has the potential to significantly reduce the impacts on both livelihood and property. While significant research has been conducted in the storm risk community on how people receive, seek, and utilize risk information, given the importance of computing technologies and social media in these activities, human-centered design stands to make important contributions to this area. Drawing on an extensive literature review and 48 interviews with hurricane experts and members of the public, this paper makes three contributions. First, we provide a broad overview of hurricane risk communication. We then offer a set of guiding insights to inform HCI research work in this domain. Finally, we identify 6 opportunities that future human centered design work might pursue. In sum, this paper offers an invitation and a starting point for HCI to take up the problem of hurricane risk communication.
Transitions to retirement – Learning to redesign one’s lifestyle

With the ongoing political debate in many western countries on retirement age and ways of designing the transition into the post-professional phase of life, the transition from work to retirement seems to be on the agenda again. The research questions guiding this study are: how do older workers plan their retirement and how do they prepare themselves for it? Which facets of their current conditions of living and working and which biographical aspects have an impact on the way they learn and prepare for this new phase of life? How do retired adults sum up the transition and the significance of learning related to this process? To better understand the ways older workers prepare themselves for this next phase of life, on the one hand, and to contrast their expectations and plans with the actual experiences of those who already went through this transitional process, we collected data from 24 qualitative interviews and from a questionnaire answered by a representative quantitative sample of German adults aged 50 to 69. Some of the initial results derived from this data are presented here. We provide some empirical insight into the transition to retirement and, based on this, point to possible ways of supporting older workers faced with this transition through educational programs.
PRBM_A_356288 991..1003

Purpose: Different studies have highlighted the importance of coping strategies in stressful situations. The Coping Orientation to Problem Experienced (COPE) by Carver et al is one of the instruments that is frequently used for measuring this aspect. The aim of this study was to carry out the cross-cultural adaptation and validation of the Brief-COPE inventory to measure coping strategies in Spanish populations. Methods: The linguistic and cultural adaptation of the Brief-COPE was carried out using the back-translation method and, after considering the results of the pilot test, the Spanish version of the instrument was configured, and subsequently administered to a convenient sample of 2135 undergraduates. A confirmatory factor analysis was carried out to examine construct validity of the Spanish adaptation of the brief-COPE; likewise, reliability was analyzed from two approaches, internal consistency and composite reliability. Concurrent validity was also tested. Results: The results showed that the Spanish version of Brief-COPE has adequate reliability values, as well as satisfactory fit indexes for the proposed 14-factor first-order structural model. Likewise, external evidence of the validity of the inventory with the variables perceived stress, level of satisfaction with life, and academic performance is provided. Conclusion: The results suggest that this instrument presents a satisfactory metric quality and, therefore, it could be useful to evaluate coping strategies, which would allow further research on its incidence and consequences on health and psychological functioning.
The Evolution of the Format of the Presidential Debates on Chilean Television: 1989-2017.

We seek to explain that the evolution of the format of televised presidential debates –in each country– is determined by the interaction between the specific characteristics of the political system and the media system. As a framework, we use Anstead’s (2016) application of the concept of speciation to the evolution of debates in parliamentary systems, together with Strömbäck’s (2008) scheme for the evolution of mediatization. We applied this scheme to the Chilean case and we concluded that the original model used –the same one that the United States used until the mid-1990’s– evolved to adapt to a multi-party presidential system and a commercial television system.
How Level Is the ‘Cognitive Playing Field’? Context Shapes Alterations in Self-Conception During the Psychedelic Experience

 (philipp.sterzer@charite.de) Abstract In Philosophy of Psychedelics , Letheby provides a convincing basis for the idea that psychedelics primarily derive their therapeutic potential through mediating favourable changes to self-related belief systems. In this commentary, we take a closer look at the role that contextual factors (‘set’ and ‘setting’) play in Letheby’s two-factor account of psychedelic therapy. While Letheby acknowledges that psychedelic effects are highly context-dependent, the exact role that context plays in self-modelling during the acute experience is not entirely clear. We argue that context plays an essential role in shaping the ‘discovery’ of alternate self-conceptions during the acute experience. Specifically, users are more likely to experience alterations in self-conception that are consistent with context-dependent features, such as one’s prior mindset (‘set’) and aspects of the external environment (‘setting’). This is consistent with a REBUS model of psychedelic effects, where a corollary effect of relaxing high-level prior beliefs is that the system becomes increasingly sensitised to bottom-up information (‘prediction errors’) from lower-level intrinsic sources and the sensory periphery. Furthermore, it may explain why a positive well-intentioned state of mind and a supportive therapeutic environment are more likely to result in positive acute experiences and long-term improvements in mental wellbeing. We see this position as being largely compatible with Letheby’s proposal, but may shift some aspects of its emphasis and framing. In particular, it may conflict with Letheby’s notion that psychedelics lead to a ‘level cognitive playing field’, where self-related hypotheses are thought to be assigned more or less
Performance of buried HDPE pipes – part I: peaking deflection during initial backfilling process

Peaking deflection caused by compacting the sidefill, referred to as the maximum change of the pipe diameter divided by the undeformed diameter, is an important parameter in the design and safety check of buried pipelines. However, quantitative equations on the deflection useful for engineering practice are very limited. In this paper, a two-dimensional finite element analysis is used to investigate the peaking deflection of high-density polyethylene (HDPE) pipes. In the analyses, the pipe–soil interaction is rationally modeled. A field trial is conducted and the finite-element modeling is evaluated by using the data measured in the field test. Parametric studies are also conducted to investigate the effects of pipe diameter, pipe stiffness, soil modulus, trench width, and compactor type on the peaking deflection of buried HDPE pipes. A new estimating tool is developed that considers the major influencing factors: pipe diameter, pipe stiffness, soil modulus, and compactor type (vibratory plate or rammer) .
PROPERTIES OF WASTE FROM COAL GASIFICATION IN ENTRAINED FLOW REACTORS IN THE ASPECT OF THEIR USE IN MINING TECHNOLOGY WŁAŚCIWOŚCI ODPADÓW ZE ZGAZOWANIA WĘGLA W REAKTORACH DYSPERSYJNYCH W ASPEKCIE ICH WYKORZYSTANIA W TECHNOLOGIACH GÓRNICZYCH

Most of the coal gasification plants based of one of the three main types of reactors: fixed bed, fluidized bed or entrained flow. In recent years, the last ones, which works as „slagging“ reactors (due to the form of generated waste), are very popular among commercial installations. The article discusses the characteristics of the waste from coal gasification in entrained flow reactors, obtained from three foreign installations. The studies was conducted in terms of the possibilities of use these wastes in mining technologies, characteristic for Polish underground coal mines. The results were compared with the requirements of Polish Standards for the materials used in hydraulic backfill as well as suspension technology: solidification backfill and mixtures for gob caulking.
Capability of helicopter CFD-simulation trimmed to free flight condition to predict flight test data

This paper presents a comparison between flight test data and simulation results obtained from trimming a computational fluid dynamics model of a complete helicopter to free flight conditions. Trim of rotor controls and helicopter attitude is accomplished by coupling the flow solver with a comprehensive rotor code. Through weak fluid-structure coupling aeroelastic effects at the main rotor are accounted for. The two cases examined are cruise flight and a condition near minimal power consumption. Control and attitude angles, mast moments, blade stresses and power consumption are compared to measured data. Concluding, the usefulness of the free flight trim method for performance prediction is evaluated.
OPTIMIZATION OF ANAEROBIC BAFFLED REACTOR (ABR) USING ARTIFICIAL NEURAL NETWORK IN MUNICIPAL WASTEWATER TREATMENT

This study is focused on simulating and optimizing design and configuration of anaerobic baffled reactor (ABR) by means of artificial neural network (ANN). This approach is aimed to assess an efficient ABR performance in various operational conditions treating municipal wastewater. For this purpose, to analyze comprehensively on a base of experimental data, the system is operated in two pilots of 48 liters net volume made of 8 compartments. In 7 months, more than 130 sets of data are obtained to be introduced to MATLAB neural network. These include removal efficiency of chemical oxidation demand (COD) and volatile fatty acids (VFAs) parameters. The finest correlative architecture obtained consists of 12 neurons along with 1 hidden and 1 output layer. It can be concluded from predicting simulation diagrams that the most favorable design and operation can be achieved in 10 to 12 hours hydraulic retention time with a six-compartment configuration. Besides, to make reactor resistant against shock loads and environmental changes, two supplementary baffles are recommended. Accordingly, soluble COD removal efficiency of more than 90% is anticipated to be achieved and VFAs fully digested even in incompatible operating conditions. Finally, the study confirms the considerable role of artificial neural network in prediction and optimization of ABR.
Carbon dioxide (CO2) gas emission based on land use types of peatland in Kinali, West Pasaman Regency

Carbon dioxide gas which is one of the greenhouse gases stated at Kyoto Protokol in 1997 can come from peatland. Conversion of peatland into farming land can accelerate the decomposition process of OM which will emit carbon dioxide gas (CO2) into the atmosphere. This study was aimed to measure CO2 emission from several types of peatland in Kinali District, West Pasaman Regency, West Sumatra Province. The research was conducted using a survey method based on the land use type (purposive sampling). The measurement of CO2 was conducted in the field using an infrared non-dispersive sensor (NDIR) found in the Carbon Dioxide (CO2) Monitor tool. Soil properties analyzed were organic-C, total N, and C/N ratio. The results showed that the different use in peatland has no significant effect on the value of CO2 emission. Carbon dioxide emission has a positive correlation (r = 0.68) with soil organic carbon content. The highest average of CO2 emission was 0.92 g/m2/d (under oil palm plantation) from soil surface and 1.56 g/m2/d (under seasonal cropland) from the surface of soil on 30 cm depth. The lowest CO2 emission was 0.68 g/m2/d (under mixed garden) from both soil surfaces.
Examining the Effect of Driving Experience on Teenage Driving Ability with Secondary Tasks

This research examined the relationship between experience and driving performance with secondary tasks. Data were collected from 42 teenage drivers and their parents using an instrumented vehicle for two one hour test track sessions spaced 12 months apart. For part of the sessions, participants followed a lead vehicle which allowed for range data to be collected. Teenage and experienced drivers’ driving were compared for cell phone and odometer tasks. Variables such as Speed, Range to Forward Vehicle, and Driving-Related Eyeglance percentages were all analyzed utilizing ANOVA. Post-hoc analysis on continuous data was performed using a Tukey HSD test. Lane Deviations were examined using Chi-Square analyses. Experienced drivers drove faster overall than teenage drivers. Teenage drivers drove faster in the 12 month session than the first session. No significant effects were found for Speed Variance, Range Variance, or Lane Deviations. Experienced drivers had a higher percentage of driving-related glances than teenage drivers. For the odometer task, teenage drivers were found to follow further behind a lead vehicle than adults. Driving experience was believed to have an effect on driver eyeglance patterns due to increased development of attentional control resulting in better switching between the task and the driving environment. Experienced drivers likely drove faster due to increased confidence in their driving ability. This research supports current GDL cell phone restrictions. A drivers’ education lesson plan framework was developed to address these differences. Future research should focus on further refining GDL legislation to address the cognitive differences between teenage and experienced drivers.
Competition between biofuel and food? The case of a jatropha biodiesel project and its effects on food security in the affected communities in Northern Ghana

v DEDICATION . vi ACKNOWLEDGEMENTS . vii TABLE OF CONTENTS.viii LIST OF FIGURES, TABLES AND MAP . xii ABBREVIATIONS. xiv GLOSSARY. xv
The role of corporate HR policy in facilitating and stimulating self-directed learning : an exploratory research

Due to the unpreceded rapidity of change in society and working life in recent decades, self-directed learning (SDL) has become increasingly important for both employees and their organisations. Although it has been argued that developing the workforce’s SDL behaviour is an inseparable part of the increasingly strategic role of corporate HR, there is a lack of scientific and practical understanding of how corporate HR policy can actually facilitate and stimulate SDL. Therefore, the twofold purpose of this research is to investigate which employee characteristics, contextual conditions, and perceived HR practices influence SDL, and to clarify the found relationships. To achieve these research goals, an exploratory research approach with a sequential mixed method design was conducted within a corporate high-tech organisation. The first quantitative cross-sectional survey study, conducted on 593 participants, resulted in a multiple regression analysis revealing that a proactive personality is the biggest predictor of SDL, although contextual conditions (i.e. feedback from others and growth potential) and perceived HR practices on training development education also exert a considerable influence on SDL. Subsequently, 10 participants were subjected to qualitative focus group interviews to clarify the quantitative findings. A conventional content analysis of HR- and employee-utterances confirmed the found relationships, showed the direction of these relationships, and provided examples behind it. Additional insights stem from the finding of more complex relationships, revealing for example that contextual conditions are also influenced by employee characteristics and perceived HR practices. Future research could contribute to this exploratory foundation by further investigating mediation and moderation effects using structural equation modelling. The paper concludes by outlining implications for practice.
Development of long term memory retention processes among learning disabled and non-disabled children

This study investigated the development of acquisition and long term retention processes in Learning Disabled (LD) and Non-Learning Disabled children aged 7-12. six subjects were randomly assigned to memorize either a list of unrelated words (with free recall), or a list of taxonomically related words (with recall cued by category) . Each subject had a 16 word list presented in visual and auditory modes. The repeated recall paradigm alternated study and test trials, with a buffer activity between trials. The acquisition phase ended when the subject reached 100% criterion. After an interval of two weeks, each subject was given 5 additional recall tests. Acquisition results indicated significant main effects for age, group (LD, Non-LD) and list type (unrelated, categorized) on measures of trial-of-Iast-error and total errors.
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(1) Serum calcium, phosphate, and albumin concentrations were not given. This is an omission on our part which we failed to note on proof reading before submitting the letter to you. Please accept our apologies. The results were as follows: serum calcium (uncorrected) 4 07 mmol/l; phosphate 1-36 mmol/l; albumin 22 0 g/l. (2) The red blood cell count was correctly reported as 4 1 x 1012/1 and not 4-1 x 109/l. The white cell count was not included in the script, but was 10-9 x 109/l. (3) Our paragraph 4 states the diagnosis to be non-Hodgkin's malignant lymphoma. The confusion over diagnosis arises because the title ofthe original letter by Mayne and Burch was "Hodgkin's disease presenting with hypercalcaemia", which was, therefore, logically used by the Journal as the heading for our letter.
The FAR protein family of parasitic nematodes

Fatty acid–and retinol-binding proteins (FARs) belong to a unique family of excreted/secreted proteins (ESPs) found exclusively in nematodes. Much of our understanding of these proteins, however, is limited to their in vitro binding characteristics toward various fatty acids and retinol and has provided little insight into their in vivo functions or mechanisms. Recent research, however, has shown that FARs elicit an immunomodulatory role in plant and animal model systems, likely by sequestering lipids involved in immune signaling. This alludes to the intricate relationship between parasitic nematode effectors and their hosts.