Miracle-dz/UniFAR-FTUs huggingface dataset:
Parental Phubbing and Adolescents’ Cyberbullying Perpetration: A Moderated Mediation Model of Moral Disengagement and Online Disinhibition

The current study sought to examine whether parental phubbing was significantly related to adolescents’ cyberbullying perpetration and if moral disengagement mediated this relationship. We further examined whether online disinhibition moderated the direct and indirect relationships between parental phubbing and adolescents’ cyberbullying perpetration. The participants included 2,407 adolescents from seven middle schools in China who completed the questionnaires regarding their experience with parental phubbing, moral disengagement, cyberbullying perpetration, and online disinhibition. Results indicated that adolescents with a high level of parental phubbing were likely to cyberbully others. Moral disengagement significantly mediated the relationship between parental phubbing and adolescents’ cyberbullying perpetration. Furthermore, online disinhibition moderated the indirect relationship between parental phubbing and adolescents’ cyberbullying perpetration. Specifically, the paths from parental phubbing to moral disengagement and from moral disengagement to cyberbullying perpetration became strengthened when adolescents experienced high levels of online disinhibition.
Attraction response of the psedatory mite Amblyseius cucumeris Oudemans to Tetranychus vienensis Zacher

The response of the predatory mite Amblyseius cucumeris Oudemans(Acari:Phytoseiidae)to Tetranychus vienensis Zacher was examined by using two-choice tests in the laboratory.The results showed different period of T.vienensis were all found had significantly attraction response to the predatory mite A.cucumeris,and the excretion of T.vienensis had no attraction response to A.cucumeris. This results showed A.cucumeris had the ability of automatic scan in the field,which indicated the predatory mite A.cucumeris could be used in the biological control of T.vienensis.
Imaging in Tubercular Choroiditis: Current Concepts

ABSTRACT Purpose Ocular tuberculosis has protean clinical manifestations. Because of its varied clinical presentation, multimodal imaging is very important to characterize the disease activity, presence of inflammation, determining therapeutic response, and detection of complications. Methods Narrative review Results In this review, various imaging modalities employed in the management of ocular tuberculosis including fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) have been reviewed. Not only do these imaging tools complement each other in providing a comprehensive assessment of the pathology, they also help in gaining valuable insights regarding the evolution of the disease. Conclusions Fundus imaging plays a vital role in the diagnosis and management of patients with posterior uveitis due to tuberculosis. Fundus imaging may have a useful role in defining clinical endpoints for ocular tuberculosis in the future.
Prognostic Value of Multiparametric MRI-Based Radiomics model: Potential Role for Chemotherapeutic Benefits in Locally Advanced Rectal Cancer.

BACKGROUND AND PURPOSE We aimed to develop a radiomics model for the prediction of survival and chemotherapeutic benefits using pretreatment multiparameter MR images and clinicopathological features in patients with locally advanced rectal cancer (LARC). MATERIALS AND METHODS 186 consecutive patients with LARC underwent feature extraction from the whole tumor on T2-weighted, contrast enhanced T1-weighted, and ADC images. Feature selection was based on feature stability and the Boruta algorithm. Radiomics signatures for predicting DFS (disease-free survival) were then generated using the selected features. Combining clinical risk factors, a radiomics nomogram was constructed using Cox proportional hazards regression model. The predictive performance was evaluated by Harrell's concordance indices (C-index) and time-independent receiver operating characteristic (ROC) analysis. RESULTS Four features were selected to construct the radiomics signature, significantly associated with DFS (P < 0.001). The radiomics nomogram, incorporating radiomics signature and two clinicopathological variables (pN and tumor differentiation), exhibited better prediction performance for DFS than the clinicopathological model, with C-index of 0.780 (95%CI, 0.718-0.843) and 0.803 (95%CI, 0.717-0.889) in the training and validation cohorts, respectively. The radiomics nomogram-defined high-risk group had a shorter DFS, DMFS, and OS than those in the low-risk group (all P <0.05). Further analysis showed that patients with higher nomogram-defined score exhibited a favorable response to adjuvant chemotherapy (AC) while the low-risk could not. CONCLUSION This study demonstrated that the newly developed pretreatment multiparameter MRI-based radiomics model could serve as a powerful predictor of prognosis, and may act as a potential indicator for guiding AC in patients with LARC.
Learning Image-Adaptive 3D Lookup Tables for High Performance Photo Enhancement in Real-Time

Recent years have witnessed the increasing popularity of learning based methods to enhance the color and tone of photos. However, many existing photo enhancement methods either deliver unsatisfactory results or consume too much computational and memory resources, hindering their application to high-resolution images (usually with more than 12 megapixels) in practice. In this paper, we learn image-adaptive 3-dimensional lookup tables (3D LUTs) to achieve fast and robust photo enhancement. 3D LUTs are widely used for manipulating color and tone of photos, but they are usually manually tuned and fixed in camera imaging pipeline or photo editing tools. We, for the first time to our best knowledge, propose to learn 3D LUTs from annotated data using pairwise or unpaired learning. More importantly, our learned 3D LUT is image-adaptive for flexible photo enhancement. We learn multiple basis 3D LUTs and a small convolutional neural network (CNN) simultaneously in an end-to-end manner. The small CNN works on the down-sampled version of the input image to predict content-dependent weights to fuse the multiple basis 3D LUTs into an image-adaptive one, which is employed to transform the color and tone of source images efficiently. Our model contains less than 600K parameters and takes less than 2 ms to process an image of 4K resolution using one Titan RTX GPU. While being highly efficient, our model also outperforms the state-of-the-art photo enhancement methods by a large margin in terms of PSNR, SSIM and a color difference metric on two publically available benchmark datasets. Code will be released at https://github.com/HuiZeng/Image-Adaptive-3DLUT.
Convalescent Plasma for the Treatment of COVID-19: Perspectives of the National Institutes of Health COVID-19 Treatment Guidelines Panel

In the United States, the efficacy and safety of convalescent plasma for treating coronavirus disease 2019 (COVID-19) is currently being tested in randomized placebo-controlled clinical trials. Treatment of individual patients with COVID-19 with convalescent plasma outside such trials is also now permitted through U.S. Food and Drug Administration Emergency Use Authorization. Here, members of the National Institutes of Health COVID-19 Treatment Guidelines Panel provide their views regarding use of convalescent plasma for treating COVID-19.
Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice

Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice induced systemic expression of GDF15. Moreover, we demonstrate the protective effects for GDF15, as GDF15-deficient mice exhibited increased proteinuria with an aggravated crescent formation and mesangial expansion in anti-GBM nephritis. Herein, GDF15 was required for the regulation of T-cell chemotactic chemokines in the kidney. In addition, we found the upregulation of the CXCR3 receptor in activated T-cells in GDF15-deficient mice. These data indicate that CXCL10/CXCR3-dependent-signaling promotes the infiltration of T cells into the organ during acute inflammation controlled by GDF15. Together, these results reveal a novel mechanism limiting the migration of lymphocytes to the site of inflammation during glomerulonephritis.
Effects of habitat fragmentation on the bank vole, Clethrionomys glareolus, in an agricultural landscape

In a patchy landscape in The Netherlands, with fragmented forest habitat for the bank vole (Clethrionomys glareofus), 51 woodlots of different area and isolation were selected. For six months, a mark-recapture method was used to measure presence, absence, and related population parameters. In April the bank vole was not captured in five woodlots. The number of unoccupied woodlots fell to zero in September near the end of the reproductive season and rose again in October. Regression analysis showed that the habitat quality of the woodlots is related to the number of captures and numbers of individuals of both sexes, thus influencing the chance of local extinction
Current Pharmacological Treatment Options for Central Serous Chorioretinopathy: A Review

Central serous chorioretinopathy (CSC) is a common cause of visual impairment in patients generally aged 20 to 60 and it is characterized by acute or chronic neurosensory detachments of the retina. Although CSC resolves spontaneously in most cases, in some patients it may cause permanent visual impairment in the working population; for this reason, several approaches, including photodynamic therapy (PDT), subthreshold micropulse laser treatment and oral mineralocorticoid receptor antagonists, have been studied as first-line treatment options for CSC. To date, half-dose PDT has provided the most encouraging results in this regard, supported by large, multicenter, randomized clinical trials such as the “Prospective Randomized Controlled Treatment Trial for Chronic Central Serous Chorioretinopathy” (PLACE) trial; however, the role of novel possible non-invasive treatment options is attracting interest. This review article aims to discuss the current pharmacological treatment options investigated for the management of CSC, including aspirin, ketoconazole, beta blockers, rifampicin and many others. In particular, further evidence about oral mineralocorticoid receptor antagonists, firstly seen as promising non-invasive alternatives for treating CSC, will be provided and discussed in light of the recent “Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months” (VICI) trial results, which have largely resized their role as possible first-line oral treatment options for treating CSC.
Histological Analysis, Bioinformatics Profile, and Expression of Methylenetetrahydrofolate Reductase (MTHFR) in Bovine Testes

Simple Summary To date, several genes have been sequenced but their corresponding protein characteristics remain unknown. This study highlights the histological structure of bovine (yellow-cattle and yak) testes as a build-up to exploring the bioinformatics profile and expression characteristics of methylenetetrahydrofolate reductase (MTHFR) in bovine testes. Our findings suggest that yellow-cattle testis have similar anatomical characteristics with that of yak, except for the weight or size, for which that of yellow-cattle is significantly higher or greater than yak. We also found that the secondary and 3D protein structures of MTHFR were similar to that of humans, with differences in the number of nucleotides, amino acids, and some physico-chemical characteristics. Moreover, MTHFR mRNA expression was higher in adult yellow-cattle and yak compared to their juvenile ones, however, its protein expression was higher but not statistically significant in adult yellow-cattle and yak compared to the juvenile ones. This provides a basis for further investigations into the regulatory function of MTHFR in bovine testes. Abstract Methylenetetrahydrofolate reductase (MTHFR), an enzyme expressed in mammalian testes, exerts a direct effect on spermatogenesis; however, its protein characteristics in bovine testes remain unknown. Here, we analysed bovine testicular structure, MTHFR bioinformatics profile, mRNA, and protein expression characteristics in yellow-cattle (y-c) and yak testis using histological procedures, bioinformatics analysis, qRT-PCR, and western blot. Testes from 13 bovines, ≤2 years juvenile (y-c, n = 3; yak, n = 3) and ≥3 years adult (y-c, n = 3; yak, n = 4) were collected and analysed. Anatomical characteristics of testis in y-c and yak were similar except the weight or size for which that of y-c was significantly higher or greater than yak. In y-c, an open reading frame (ORF) for 2600 nucleotides sequence, encoding 655 amino acids showed high homology with zebu cattle (99.51%) and wild yak (98.68%). Secondary and 3D protein structures were similar to that of humans with differences in the number of nucleotides, amino acids, and some physico-chemical characteristics. MTHFR mRNA expression in y-c and yak were significantly higher in adult testes compared with juvenile ones. However, its protein expression was higher, but not statistically significant, in adult y-c and yak compared to the juvenile ones. The highlights and inferences of these and other findings are discussed.
Elevated markers of gut leakage and inflammasome activation in COVID‐19 patients with cardiac involvement

A high proportion of COVID‐19 patients have cardiac involvement, even those without known cardiac disease. Downregulation of angiotensin converting enzyme 2 (ACE2), a receptor for SARS‐CoV‐2 and the renin‐angiotensin system, as well as inflammatory mechanisms have been suggested to play a role. ACE2 is abundant in the gut and associated with gut microbiota composition. We hypothesized that gut leakage of microbial products, and subsequent inflammasome activation could contribute to cardiac involvement in COVID‐19 patients.
Effect of Telemedicine on Quality of Care in Patients with Coexisting Hypertension and Diabetes: A Systematic Review and Meta-Analysis.

Background: With the development of technology and the need for individualized and continuous support for patients with chronic conditions, telemedicine has been widely used. Despite the potential benefits of telemedicine, little is known about its effect on the quality of care (QoC) in people with hypertension and comorbid diabetes, who face more challenges in disease management than those with hypertension or diabetes alone. This study aimed to examine the effect of telemedicine on QoC for patients with hypertension and comorbid diabetes by synthesizing findings from clinical trials. Methods: This systematic review and meta-analysis were developed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Four major electronic databases from inception to March 2020 were searched. Studies were screened using predetermined criteria. Data were extracted and tabulated into tables. The primary outcomes were QoC indicators, including outcomes (e.g., blood pressure [BP] and glycemic control), process, and experience of care. Quantitative data were pooled and presented in forest plots. Qualitative narratives were also used. Results: Five studies from four clinical trials were included in this review, with intervention durations ranging from 3 to 6 months. Telemedicine significantly decreased BP by 10.4/4.8 mm/Hg, but its effect on glycemic control was inconsistent. Telemedicine also improved experience of care (e.g., patient perception and engagement). Various indicators for process of care were assessed, including medication adherence, BP monitoring, and self-efficacy, with mixed findings. Conclusions: Telemedicine has great potential to improve the QoC, particularly outcomes of care, for patients with hypertension and comorbid diabetes. Health care professionals may consider using available telemedicine to facilitate communication and interaction with their patients, thereby helping them with disease management. Long-term, large-scale studies are needed to test the generalizability and sustainability of the telemedicine programs.
Populus ciliata mediated synthesis of silver nanoparticles and their antibacterial activity

Design and synthesis of bactericidal and fungicidal agents is very important to protect human beings from different diseases. Silver nanoparticles (AgNPs) possess good bactericidal properties. Synthesis of these nanoparticles (NPs) via green route is cost‐effective and environmentally harmonious as compared to the chemical and physical approaches. In this work, AgNPs were synthesized through green synthesis method using Populus ciliata leaf extract. The synthesized AgNPs were characterized by x‐ray diffraction (XRD), ultraviolet‐visible (UV‐Vis) spectroscopy, Fourier‐transform infrared (FT‐IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive x‐ray (EDX) techniques. The XRD pattern depicted the characteristic Bragg's peaks of (111), (200), (220), and (311) planes which are the features of face centered cubic (FCC) geometry of the synthesized AgNPs. TEM micrographs revealed the spherical shaped particles having average size of 4 nm. The AgNPs showed inhibitory effects against selected gram positive (Staphylococcus epidermidis and Streptococcus pyogenes) and gram negative bacteria (Klebsiella pneumoniae, Serratia marcescens, and Pseudomonas pseudoalcaligenes). The maximum zone of inhibition (26 mm) was observed for gram negative bacterium (Serratia marcescens) when 25 mg/ml solution of AgNPs was used and for similar concentration of these NPs, the maximum zone of inhibition (25 mm) was observed against gram positive bacteria (S. pyogenes). The results indicated good bactericidal potential of the synthesized AgNPs.
When Does Physician Use of AI Increase Liability?

An increasing number of automated and artificial intelligence (AI) systems make medical treatment recommendations, including personalized recommendations, which can deviate from standard care. Legal scholars argue that following such nonstandard treatment recommendations will increase liability in medical malpractice, undermining the use of potentially beneficial medical AI. However, such liability depends in part on lay judgments by jurors: when physicians use AI systems, in which circumstances would jurors hold physicians liable? Methods: To determine potential jurors’ judgments of liability, we conducted an online experimental study of a nationally representative sample of 2,000 U.S. adults. Each participant read 1 of 4 scenarios in which an AI system provides a treatment recommendation to a physician. The scenarios varied the AI recommendation (standard or nonstandard care) and the physician’s decision (to accept or reject that recommendation). Subsequently, the physician’s decision caused harm. Participants then assessed the physician’s liability. Results: Our results indicate that physicians who receive advice from an AI system to provide standard care can reduce the risk of liability by accepting, rather than rejecting, that advice, all else being equal. However, when an AI system recommends nonstandard care, there is no similar shielding effect of rejecting that advice and so providing standard care. Conclusion: The tort law system is unlikely to undermine the use of AI precision medicine tools and may even encourage the use of these tools.
Audiologic Outcome of Cochlear Implantation in Children With Cochlear Nerve Deficiency

Objective/Hypothesis: The aim of this study was to investigate cochlear implantation (CI) outcome in children with nerve deficiency. Study Design: Retrospective chart review. Methods: A total of seven children with prelingual profound deficiency (hypoplasia or aplasia) were included. A control group of 10 CI children with no cochlear nerve anomalies was also included. In addition to implant stimulation levels, children's performance on pure-tone audiometry, speech reception measure, and auditory and speech skills ratings were compared across groups. Additionally, pre- and postoperative audiologic results were evaluated for the group with nerve deficiency. Results: In general, children with nerve deficiency performed poorer than those without nerve deficiency on all tested measures. Stimulation levels were considerably higher and more variable than the control group. Results further showed that performance was dependent on the diameter of the internal auditory canal. Conclusion: Overall, cochlear implantation outcome in children with auditory nerve deficiency is poorer and extremely more variable than those without nerve deficiency. However, three of the patients had a noticeable improvement in auditory performance postimplantation suggesting that CI is a viable option in this population but expected benefit can be dependent on the status of the cochlear nerve.
Reflecting glory or deflecting stigma? The interplay between status and social proximity in peer evaluations

How do candidates’ status and social proximity to members of the evaluating audience interact to shape recognition in peer-based evaluative settings? In this study, we shed light on this question by adopting a mixed-method approach. We first examined field data on the conferral of awards in a peer-based evaluative contest–“The Silver Tag”–which is one of the most prestigious digital advertising awards contests in Norway. The field study revealed the existence of a negative interaction between status and social proximity on the allocation of awards. We then conducted two experiments to probe the mechanisms responsible for this finding. In the first experiment, we replicated the main pattern observed in the field study. In the second experiment, we showed that the interaction effect is contingent on the nature of the evaluative setting. When audience members’ decisions were in the public domain (i.e., the other audience members knew them), social proximity tempered the effect of status on candidates’ recognition, but it did not when decisions were private (i.e., the other audience members did not know them). We conclude by discussing several implications of our study for research on the socio-psychological processes underlying evaluative outcomes in tournament rituals.