Miracle-dz/UniFAR-FTUs huggingface dataset:
CIA_A_315090 1151..1159

1Department of Orthopaedic and Spine Surgery, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan; 2Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan; 3Department of Orthopaedic Surgery, Dokkyo Medical University, Saitama Medical Center, Saitama, Japan Objective: Cemented hemiarthroplasty is recommended for the vulnerable hip fracture population because of beneficial long-term outcomes. However, the association between cemented hemiarthroplasty and short-term mortality is controversial. To increase a preparedness of potential complication after cemented hemiarthroplasty, we aimed to evaluate the trajectory of the effect of cemented hemiarthroplasty on short-term in-hospital outcomes. Methods: We investigated in-hospital mortality and complications between cemented hemiarthroplasty and cementless hemiarthroplasty using a nationwide multicenter database from 2010 to 2016 with a propensity-score matching analysis. We analyzed in-hospital mortality from 1 to 14 days after surgery. We also investigated in-hospital complications that may associate with mortality. Results: After matching of 31,322 cases, we found no significant difference in 30-day inhospital mortality between the cemented and cementless hemiarthroplasty groups (hazard ratio, HR [95% confidence interval, CI], 1.2 [0.89–1.6], p = 0.23). However, the 1to 10-day postoperative mortality rates were significantly higher in the cemented group and the association becomes weaker as the postoperative period increased (day 1; HR [95% CI]: 3.5 [1.6–7.68]; day 10; HR [95% CI]: 1.59 [1.07–2.37]). The incidence of stroke and intensive care unit (ICU) admission was also significantly higher in the cemented group. Conclusion: Cemented hemiarthroplasty was not significantly associated with an increase in overall in-hospital mortality but was significantly associated with short-term mortality from 1-day to 10-day after surgery. The incidence of stroke and ICU admission was also significantly higher in the cemented group. Surgeons should pay more attention to the risk of mortality and stroke in patients undergoing cemented hemiarthroplasty, especially in the early days of hospitalization.
Complexes formed by the siderophore-monosulfactam conjugate BAL30072 and their interaction with the outer membrane receptor PiuA of P. aeruginosa

Nuclear magnetic resonance and infrared spectroscopy have been used to investigate the formation of complexes of BAL30072 with Fe3+ and Ga3+ in solution and to collect geometrical parameters supporting reliable 3D structure models. Structural models for the ligand-metal complexes with different stoichiometries have been characterized using density functional theory calculations. Blind ensemble docking to the PiuA receptor from P. aeruginosa was performed for the different complexes to compare binding affinities and statistics of the residues most frequently contacted. When compared to analogues, BAL30072 was found to have an intrinsic propensity to form complexes with low ligand-to-metal stoichiometry. By using one of the sulfate oxygen atoms as a third donor in addition to the bidentate pyridinone moiety, BAL30072 can form a L2M complex, which was predicted to be the one with the best binding affinity to PiuA. The example of BAL30072 strongly suggests that a lower stoichiometry might be the one recognized by the receptor, so that to focus only on the highest stoichiometry might be misleading for siderophores with less than six donors. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation
KNOWLEDGE – International Journal Vol. 28.2 December, 2018

Introduction: The cervical vertebrae are cranially placed, moveable vertebrae in the human body. The characteristic feature of these vertebrae are the presence of a Foramen Transversarium (FT) in each lateral mass. A plexus of sympathetic nerves surrounding the Vertebral Artery (VA) and Vertebral Veins (VV) passes through the FT. The variable number and size of FT may lead to clinically significant conditions. It may be due to variable course of the VA which implicates an embryological basis. Aims: The objective of the present study is to find out the incidence of accessory FT in the cervical vertebrae and its morphological and clinical significance. Material and Methods:There were 117 dried cervical vertebrae available in the Department of Anatomy of Medical Sciences Stip. They were macroscopically studied to find variations in the number of FT. Results: Out of 117 cervical vertebrae accessory FT were found in 25 vertebrae (21.3%). The accessory FT were unilateral in 15 vertebrae (12.8%) and bilateral in 10 vertebrae (8.7%). The unilateral foramina were more common than the bilateral one. The accessory FT were smaller and posteriorly placed compared to the regular FT. Conclusions: In the present study 21.3% of cervical vertebrae showed accessory FT. Among them the unilateral accessory FT was more common than the bilateral variety. The accessory foramina were mostly observed in the lower cervical vertebrae. These anatomical variations and morphology of the FT is useful in the operations involving spine surgeries. It is also of great value to the radiologists in the interpretation of X-ray films and CT-scans.
The relationship between emotional intelligence, attachment styles and optimism with Martials satisfaction

Purpose: The aim of the present study was to investigate the relationship between emotional intelligence, attachment styles and optimism with mental health and marital satisfaction of couples who refer to Andimeshk counselling centers in the period of 3 months. Material & Method: 15o volunteer couples who were selected by applying multi cluster sampling method. Measurement tools include Emotional intelligence scale (Wang and Lu, 2002) Adult attachment scale (Collins and Reid, 1990) Optimism inventory of couples (Rajabi, 2002) Goldberg’s general health questionnaire (1989) and marital satisfaction scale (sanaee, 2001) were applied to measure variables. Findings: The data analysis was performed by Pearson correlation coefficient and step by step regression. Results showed that there was a significant positive correlation between emotional intelligence, Adult attachment scale, Optimism, general and marital satisfaction. results of regression analysis show that emotional intelligence, Adult attachment scale, Optimism, general health can predict marital satisfaction significantly Discussion: finding reveals for finding marital satisfaction couples should be able to emotionally and cognitively manage themselves and find optimism ad general health. Key words
ACELL Apr. 45/4

Schneider, Achim G. , Karim R. Sultan, and Dirk Pette. Muscle LIM protein: expressed in slow muscle and induced in fast muscle by enhanced contractile activity. Am. J. Physiol. 276 (Cell Physiol. 45): C900–C906, 1999. —To identify early changes in gene expression during the fast-toslow transition induced by chronic low-frequency stimulation, total RNA was extracted from 12-h-stimulated tibialis anterior (TA) muscles of rats and amplified by differential display RT-PCR. Among the signals of differentially expressed mRNAs, a cDNA ,300 bp in length, which was almost undetectable in control TA muscles but prominent in stimulated TA and normal soleus muscles, was identified. This cDNA was cloned and identified as corresponding to the mRNA of the muscle LIM protein (MLP). Its differential expression in control, stimulated TA, and soleus muscles was verified by Northern blotting. Antibodies against MLP were used to identify by immunoblot analysis a protein of 22 kDa, the predicted molecular mass of MLP. Immunohistochemistry revealed strong reactivity for MLP in all fibers of normal soleus muscle and faint staining of some type IIA and type I fibers in control TA muscle. These fibers increased in number and staining intensity in 4-day-stimulated TA muscle. MLP thus seems to play an essential role during the rearrangement of cytoskeletal and/or myofibrillar structures in transforming adult muscle fibers.
Evaluation of hepatic brosis in HIV/HCV Co- infected individuals in Yaoundé, Cameroon: Usefulness of APRI score in resource-constrained settings

Rodolphe Steven Dobseu CIRCB, University of Ngaoundere Aubin Joseph Nanfack (  a_nanfack@yahoo.fr ) Chantal Biya International Reference Center for research on prevention and management of HIV/AIDS https://orcid.org/0000-0003-2896-0508 Mathurin Kowo CHUY Georgia Ambada CIRCB Rachel Simo Kamgaing CIRCB Collins Chenwi CIRCB Nadine Fainguem CIRCB Aude Ka’e CIRCB Eric Ngangoum CIRCB, University of Ngaoundere Samuel Martin Sosso CIRCB Clergé Tchiegang Universite de Ngaoundere Alexis Ndjolo CIRCB
2D Simulation of a Flow Past a Rectangle Near a Wall

A numerical study has been done on a rectangle in a 2D pipe flow. Therefore a Matlab code is made from scratch on basis of the SIMPLE algorithm. In the appendix is explained step by step exactly how all equations are implemented in Matlab. Focusing on low Reynolds numbers (1<Re<80) are different simulations made of the flow with the rectangle. Different heights of the rectangle in the pipe in a pressure driven flow are considered. Drag, lift and torque coefficients that were obtained from these simulations are plotted against the Reynolds number. Furthermore are shear flows as a consequence of a moving wall considered. Plots and other data of the dimensionless coefficients are included. The goal to make a good simulation of the flow past a rectangle is achieved. Different possible improvements to the code have been opposed, so it can be improved in the future to make also simulations of more complex geometries than a rectangle.
Work Environments that Foster and Inhibit Creativity and Innovation

Little is known about the influence of the creative and bureaucratic work environments on the dimensions of creativity and innovation in organisations operating in the United Arab Emirates. The objective of this paper is to examine the combined effect of the creative work environment determinants and organisational bureaucracy dimensions on the constructs of creativity and innovation. Results indicate that the 'stimulant' determinants of the creative work environment had strong, positive and statistically significant effects on creativity and innovation, while the dimension of organisational impediment ('obstacle' determinant) had a negative influence on innovation. The findings also indicate that the organisational bureaucracy factors had a moderate, negative effect on both creativity and innovation. It was also found that the determinants of the creative work environment provided no statistical significant predictive power, after having statistically controlled for the predictive effects of organisational bureaucracy.
ANAEMIA IN PREGNANT WOMEN IN A RURAL BLOCK OF KASHMIR VALLEY: ITS PREVALENCE AND SOCIO-

Background: Anaemia is a major public health problem in developing countries like India and is especially seen among women of childbearing age, during pregnancy and lactation. Nearly two-thirds of pregnant and one-half of nonpregnant women in developing countries have anaemia, which increases the risk of maternal and fetal mortality and morbidity. Aims & Objective: The study was designed to assess the prevalence of anaemia in pregnant women and to report the socio-demographic factors associated with anaemia during pregnancy. Material and Methods: This is a Cross sectional study. The study was conducted in Block Hajan, the rural field practice area under the department of community medicine, Sher-i-Kashmir Institute of Medical Sciences (SKIMS) Soura.482 pregnant women were examined and screened for anaemia. Haemoglobin level, age, education, income, type of family and parity were among the various variables studied. Statistical analysis was done by using Chi-square test using SPSS statistical package version (Chicago 11, IL). Results: A high prevalence (91%) of anaemia (Hb<11g/dl) was observed. The prevalence of anaemia was significantly higher in those aged ≥ 35 years. A highly significant association was found with woman’s age, parity, educational and socio-economic status. However, family type and birth interval were not significantly associated with anaemia. Conclusion: There is a high prevalence of anaemia among pregnant women and there is need for correcting this to improve the overall health of pregnant women. Key-Words: Pregnant Women; Anaemia; Haemoglobin; Rural Area
Institutional Knowledge at Singapore Management University Entity Identification in Database Integration: An Evidential Reasoning Approach

Entity identi(cid:12)cation is the problem of matching object instances from di(cid:11)erent databases which correspond to the same real-world entity. In this paper, we present a 2-step entity identi(cid:12)cation process in which attributes for matching tuples may be missing in certain tuples, and thus need to be derived prior to the matching. To match tuples, we require identity rules which specify the conditions to be satis(cid:12)ed by a pair of tuples, from di(cid:11)erent databases, before they can be considered as modeling the same real-world entity. We also introduce ILFD's (instance-level functional de-pendencies) as a form of inference rules which derive the missing identifying attributes. In order to provide more interesting integrated results to the users, we allow both identity rules and ILFD's to contain inde(cid:12)-niteness represented as necessary and possible support information. Based on support logic programming[2], we develop an approach to perform reasoning on the local databases using identity rules and ILFD's.
Auto-intersection du dualisant relatif des courbes modulaires Xo (N).

Une surface arithmetique est l'unique modele regulier minimal d'une courbe lisse et geometriquement connexe de genre g non nul sur un corps de nombres. Arakelov [1] a developpe en 1972 une theorie des intersections pour les diviseurs "compactifies" sur une teile surface. Cette theorie permet d'attacher ä la courbe des invariants numeriques analogues ä ceux definis dans le cadre geometrique: l'auto-intersection du dualisant relatif et le degre de son image directe. Ces invariants sont centraux dans les preuves de la conjecture de Mordell sur les corps de fonctions en toute caracteristique dues ä Parshin, Arakelov et Szpiro [21]. On s'interesse ici ä l'auto-intersection du dualisant relatif.
Lipopolysaccharide-lnduced Fetal Death: The Role of Tumor-Necrosis Factor Alpha1

Lipopolysaccharide (LPS) administration has been known to cause murine fetal death for over 50 years, but the responsible mechanism(s) remains unclear. We used the LPS-hyporesponsive murine strain, C3H/HeJ, to 1) establish whether LPS-induced fetal death is due to a maternal or fetal response to LPS and 2) to investigate the involvement of tumor necrosis factor alpha (TNFa) in fetal death caused by LPS. C3H/HeJ (LPS-hyporesponsive) or C3H/HeN (LPS-responsive) females were mated with C57B1/6 or C3H/HeN males (both LPS-responsive). Administration of 10 jig LPS caused fetal death in C3H/HeN mothers. However, up to 1000 ,. g LPS did not result in the death of LPS-responsive fetuses when administered to C3H/HeJ mothers. Systemic administration of TNFa was able to cause fetal death in both C3H/HeN and C3H/HeJ strains of mice. Pretreatment of pregnant C3H/HeN mice with anti-TNFO antibodies significantly reduced fetal death caused by LPS administration. The administration of a sublethal dose of TNFot plus 10 jig LPS to pregnant C3H/HeJ mice restored abortifacient activity. These results indicate that LPS-induced fetal death is due to a maternal response as opposed to a direct fetal response to LPS and that TNFO appears to be an important mediator of fetal death caused by LPS.
Adenine nucleotide regulation in pancreatic -cells: modeling of ATP/ADP-Ca interactions

Fridlyand, Leonid E. , Li Ma, and Louis H. Philipson. Adenine nucleotide regulation in pancreatic -cells: modeling of ATP/ADP-Ca interactions. Am J Physiol Endocrinol Metab 289: E839–E848, 2005. First published June 28, 2005; doi:10.1152/ajpendo.00595. 2004. —Glucose metabolism stimulates insulin secretion in pancreatic -cells. A consequence of metabolism is an increase in the ratio of ATP to ADP ([ATP]/[ADP]) that contributes to depolarization of the plasma membrane via inhibition of ATP-sensitive K (KATP) channels. The subsequent activation of calcium channels and increased intracellular calcium leads to insulin exocytosis. Here we evaluate new data and review the literature on nucleotide pool regulation to determine the utility and predictive value of a new mathematical model of ion and metabolic flux regulation in -cells. The model relates glucose consumption, nucleotide pool concentration, respiration, Ca flux, and KATP channel activity. The results support the hypothesis that -cells maintain a relatively high [ATP]/[ADP] value even in low glucose and that dramatically decreased free ADP with only modestly increased ATP follows from glucose metabolism. We suggest that the mechanism in -cells that leads to this result can simply involve keeping the total adenine nucleotide concentration unchanged during a glucose elevation if a high [ATP]/[ADP] ratio exits even at low glucose levels. Furthermore, modeling shows that independent glucose-induced oscillations of intracellular calcium can lead to slow oscillations in nucleotide concentrations, further predicting an influence of calcium flux on other metabolic oscillations. The results demonstrate the utility of comprehensive mathematical modeling in understanding the ramifications of potential defects in -cell function in diabetes.
Effects of acute a2-blockade on insulin action and secretion in humans

Natali, Andrea, Amalia Gastaldelli, Alfredo Quiñones Galvan, Anna Maria Sironi, Demetrio Ciociaro, Giovanna Sanna, Pierre Rosenzweig, and Ele Ferrannini. Effects of acute a2-blockade on insulin action and secretion in humans. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E57– E64, 1998. —We tested whether acute a2-blockade affects insulin secretion, glucose and fat metabolism, thermogenesis, and hemodynamics in humans. During a 5-h epinephrine infusion (50 ng·min21 ·kg21) in five volunteers, deriglidole, a selective a2-receptor inhibitor, led to a more sustained rise in plasma insulin and C-peptide levels (159 6 14 vs. 128 6 6, and 1273 6 18 vs. 153 6 14 pM, P , 0.01 vs. placebo) despite a smaller rise in plasma glucose (10.90 6 0.4 vs. 11.5 6 0.3 mM, P , 0.01). Another 10 subjects were studied in the postabsorptive state and during a 4-h hyperglycemic (14 mM) clamp, coupled with the ingestion of 75 g of glucose at 2 h. In the postabsorptive state, hepatic glucose production, resting energy expenditure, and plasma insulin, free fatty acid (FFA), and potassium concentrations were not affected by acute a2-blockade. Hyperglycemia elicited a biphasic rise in plasma insulin (to a peak of 140 6 24 pM), C-peptide levels (1,520 6 344 pM), and insulin secretion (to 410 6 22 pmol/min); superimposed glucose ingestion elicited a further twofold rise in insulin and C-peptide levels, and insulin secretion. However, a2-blockade failed to change these secretory responses. Fasting blood b-hydroxybutyrate and glycerol and plasma FFA and potassium concentrations all declined with hyperglycemia; time course and extent of these changes were not affected by a2-blockade. Resting energy expenditure (125 vs. 116%, P , 0.01) and external cardiac work (128% vs. 119%, P , 0.01) showed larger increments after a2blockade. We conclude that acute a2-blockade in humans 1) prevents epinephrine-induced inhibition of insulin secretion, 2) does not potentiate basal or intravenousor oral glucoseinduced insulin release, 3) enhances thermogenesis, and 4) increases cardiac work.
TYRO protein tyrosine kinase-binding protein predicts favorable overall survival in osteosarcoma and correlates with antitumor immunity

To explore the prognostic significance and underlying mechanism of TYRO protein tyrosine kinase-binding protein (TYROBP) in osteosarcoma. Firstly, the expression of TYROBP was analyzed using the t test. The Kaplan–Meier plotter analysis and a receiver operating characteristic curve were performed to evaluate the influence of TYROBP on overall survival (OS). Further, Cox regression analysis was conducted to predict the independent prognostic factors for OS of osteosarcoma patients, and a nomogram was constructed. Then, the relationship between TYROBP and clinicopathological characteristics was determined using statistical methods. Enrichment analyses were conducted to evaluate the biological functions of TYROBP. Finally, the ESTIMATE algorithm was used to assess the association of TYROBP with immune cell infiltration. TYROBP was significantly increased in osteosarcoma (all P < .001). However, the high expression of TYROBP was related to better OS in osteosarcoma patients. Cox regression analysis showed that TYROBP was an independent prognostic factor for predicting OS (P = .005), especially in patients of the male sex, age <18 years, metastasis, and tumor site leg/foot (all P < .05). Besides, TYROBP mRNA expression was significantly associated with the tumor site (P < .01) but had no remarkable relationship with age, gender, and metastasis status (all P > .05). Functional annotation and gene set enrichment analysis (GSEA) revealed that TYROBP was mainly involved in immune-related pathways. Importantly, TYROBP positively correlated with immune scores (P < .001, R = .87). TYROBP served as an independent prognostic biomarker for OS in osteosarcoma. High TYROBP expression might prolong the survival of osteosarcoma patients mainly through promoting antitumor immunity.
Evaluation and management of pain in geriatric patients who were diagnosed in Emergency Department

Rybojad Beata, Chudzik Robert, Mendrek Sim Magdalena, Pawelec Sławomir, Matuszewski Piotr, Piróg Paweł, Rybojad Paweł. Evaluation and management of pain in geriatric patients who were diagnosed in Emergency Department. Journal of Education, Health and Sport. 2019;9(2):393-402. eISNN 2391-8306. DOI http://dx.doi. org/10.5281/zenodo.2579120 http://ojs.ukw. edu.pl/index.php/johs/article/view/6632 https://pbn.nauka. gov.pl/sedno-webapp/works/905933
Modelling of Thin Layer Drying of Cocoyam Slices of Varying Thickness at Different Temperatures

Article history: Received 02 May, 2021 Revised 20 May, 2021 Accepted 24 May, 2021 Available online 30 Jun, 2021 Drying of agricultural and food products reduces their moisture content and this help to avoid microbiological action which could lead to deterioration. In this study, the convective hot air oven was used to dry sliced cocoyam pieces to enable uniform drying. Proximate and functional analyses were carried out before and after drying. Eight selected semi-empirical drying models were fitted to the drying data using non-linear regression analysis. The most appropriate models were selected using the coefficient of determination (R) and sum square error (SSE). The result obtained showed that there were reductions of the values of the cocoyam nutrients after drying. The cocoyam drying regime was characteristically in the constant and falling rate period. The optimum drying temperature for cocoyam was found to be 60 C. The logarithmic model showed a better fit for the drying kinetic data of cocoyam in comparison with other tested models. Empirical models developed gave the relationship between moisture ratio to sizes and drying time for the various slice thicknesses and at the different temperatures studied. Activation energy obtained was between 14.802 kJ/mol and 19.138 kJ/mol while the effective moisture diffusivity was between 7.02×10 and 2.00×10 m/s for the different thicknesses at the various temperatures studied.