Miracle-dz/UniFAR-FTUs huggingface dataset:
Mucosal Microbiota Associated With Eosinophilic Esophagitis and Eosinophilic Gastritis

Objective: The aim of the study was to determine the mucosal microbiota associated with eosinophilic esophagitis (EoE) and eosinophilic gastritis (EoG) in a geographically diverse cohort of patients compared to controls. Methods: We conducted a prospective study of individuals with eosinophilic gastrointestinal disease (EGID) in the Consortium of Eosinophilic Gastrointestinal Disease Researchers, including pediatric and adult tertiary care centers. Eligible individuals had clinical data, mucosal biopsies, and stool collected. Total bacterial load was determined from mucosal biopsy samples by quantitative polymerase chain reaction (PCR). Community composition was determined by small subunit rRNA gene amplicons. Results: One hundred thirty-nine mucosal biopsies were evaluated corresponding to 93 EoE, 17 EoG, and 29 control specimens (18 esophageal) from 10 sites across the United States. Dominant community members across disease activity differed significantly. When comparing EoE and EoG with controls, the dominant taxa in individuals with EGIDs was increased (Streptococcus in esophagus; Prevotella in stomach). Specific taxa were associated with active disease for both EoE (Streptococcus, Gemella) and EoG (Leptotrichia), although highly individualized communities likely impacted statistical testing. Alpha diversity metrics were similar across groups, but with high variability among individuals. Stool analyses did not correlate with bacterial communities found in mucosal biopsy samples and was similar in patients and controls. Conclusions: Dominant community members (Streptococcus for EoE, Prevotella for EoG) were different in the mucosal biopsies but not stool of individuals with EGIDs compared to controls; taxa associated with EGIDs were highly variable across individuals. Further study is needed to determine if therapeutic interventions contribute to the observed community differences.
The effect of entrepreneurial orientation on export performance: Evidence from manufacturing SMEs in Tanzania

Abstract This paper examines the effect of innovativeness and proactiveness on export performance and the moderating effect of risk-taking on the relationship between innovativeness, proactiveness, and export performance. A quantitative research approach and a cross-sectional survey design were employed. In addition, stratified random sampling was employed to obtain data from 250 managers of manufacturing-exporting SMEs. Hypotheses were examined using the PROCESS macro test. The findings affirm that innovativeness is a significant predictor of export performance (β = 0.3854 and p < 0.001). However, negative effect of proactiveness on export performance was revealed (β = −0.1748 and p < 0.001). Risk-taking was found to be a significant moderator of the relationships between innovativeness and export performance (β = 0.2234 and p = 0.0009) as well as proactiveness and export performance (β = 0.1041 and p = 0.0271). The findings of this study broaden the applicability of RBV theory to an exporting context by examining the process through which entrepreneurial-orientation (EO) as an intangible resource leads to successful export performance. This study also contributes to the debate on the EO-export performance relationship by establishing the interplay effect between EO dimensions in enhancing export performance. The study contributes that risk-taking significantly moderates the relationship between innovativeness, proactiveness and export performance. Furthermore, the study recommends that the owners-managers of exporting SMEs develop and implement more innovative strategies, respond quickly to seize available export market opportunities, cultivate a positive attitude toward risks, and increase their capacity to take risks in order to improve their export performance.
Analgesic Effect of Ultrasound-Guided Anterior Quadratus Lumborum Block at the L2 Level in Patients Undergoing Laparoscopic Partial Nephrectomy: A Single-Center, Randomized Controlled Trial

Objectives This study aimed to evaluate the effect of ultrasound-guided anterior quadratus lumborum block (QLB) at the L2 level in patients undergoing laparoscopic partial nephrectomy. Methods Patients who were 18–70 years old with an American Society of Anesthesiologists (ASA) physical status of 1-2 and were scheduled for elective laparoscopic partial nephrectomy were recruited into the cluster randomized controlled trial. Sixty-three patients were randomly allocated to receive QLB (group Q, n = 32) or no block (group C, n = 31). The patients were not masked to the group allocations. The postoperative follower was blinded to the group allocations. All patients received total intravenous anesthesia, the same multimodal analgesic regimen, and rescue analgesia when needed. The primary outcome was perioperative cumulative sufentanil consumption. Results 30 patients in group Q and 29 patients in group C were included in the statistical analysis. Block-related complications were not found in this study. Sufentanil consumption during the perioperative period (155.41 [19.58] vs 119.37 [12.41] μg, p < 0.001) and sufentanil dosage during surgery and 0–6 h, 6–12 h, and 12–24 h after surgery were lower in group Q than in group C, while 24–48 h after surgery was similar between both groups. The median sensory blockade area in group Q was T9-L1. Comparison of invasive blood pressure (BP) and heart rate (HR) before and after skin incision in group C was statistically significant, but there was no significant difference in group Q. Both at rest and during activity, numerical rating scale (NRS) scores and the incidence of rescue analgesia were lower in group Q at any time point after surgery. The incidences of postoperative nausea and vomiting (PONV), time from postoperative to discharge, postoperative recovery quality, or anesthesia satisfaction were similar between the two groups. Conclusions Anterior QLB at the L2 level can reduce the perioperative dosage of sufentanil and the degree of postoperative pain in patients undergoing laparoscopic partial nephrectomy, but it did not improve postoperative recovery quality and anesthesia satisfaction.
Early menarche, menstrual duration with dysmenorrhea in adolescents in Surabaya

Introduction: Early menarche and long menstrual cycle were several factors that influence the occurrence of dysmenorrhea. Girls who have early menarche got a higher risk of experiencing dysmenorrhea as well as girl who experience long menstrual cycle. These both problems resulted excessive uterine contractions and secreted more prostaglandins so that causing dysmenorrhea. This study aims to analyze whether there is a relationship between early menarche, menstrual duration and dysmenorrhea in class VIII students in 2019-2020 school year at SMPN 20 Surabaya. Methods: The design of this study used a cross-sectional approach. The population was all students of class VIII 2019-2020 school year at SMPN 20 Surabaya. Sample were 140 students which were taken based on proportional stratified simple random sampling technique. Retrieval of data by taken through filling out online forms. The independent variable were early menarche and menstrual duration, and the dependent variable was dysmenorrhea. The data analysis used the Spearman rank test with the significance level α = 0,05. Results: Research result of first independent variable, it was obtained p value = 0.022 which means there is a relationship between early menarche and dysmenorrhea in class VIII students of SMPN 20 Surabaya, and research for the second independent variable, it was obtained p value = 0.04 which means there is a relationship between menstrual duration and dysmenorrhea in class VIII students of SMPN 20 Surabaya. Conclusion: Students who experience early menarche and have a long menstrual duration are more at risk of experiencing dysmenorrhea with severe pain levels. Students who experience early menarche and long menstrual periods are able to minimize the incidence of dysmenorrhea by such as maintaining a regular diet, consuming nutritious food intake, and taking pain relievers if dysmenorrhea occurs.
Real-World Comparative Evaluation of Add-On Glucagon-like Peptide 1 Receptor Agonist in Type 2 Diabetes Treated with or without Insulin

Glucagon-like peptide 1 receptor agonist (GLP-1 RA) is a potent antidiabetic agent with cardiorenal and weight-losing benefits in patients with type 2 diabetes (T2D). The combination of GLP-1 RA with basal insulin has been suggested in several clinical studies as a useful treatment for intensifying insulin therapy in T2D. However, there has been no real-world evidence study comparing the glycemic effects of GLP-1 RAs add-on to background treatment with and without insulin. A retrospective study was performed in 358 patients with T2D who initiated liraglutide or dulaglutide. Among them, 147 patients were prior and concurrent insulin users, and 211 patients were non-insulin users. After 12 months of GLP-1 RA treatment, the changes in hemoglobin A1c (HbA1C) and body weight were evaluated. The effectiveness of GLP-1 RAs on HbA1C reduction was greater in insulin users than non-insulin users at 12 months (−1.17% vs. −0.76%; p = 0.018). There was no significant difference in body weight change between insulin users and non-insulin users at 12 months (−1.42 kg vs. −1.87 kg; p = 0.287). The proportion of responders (decrease of HbA1C > 1%) in insulin users was much higher than that in non-insulin users (48% vs. 37 %; p = 0.04). In insulin users, those who had increased insulin dosage at 12 months had significantly less HbA1C reduction than that of non-increased patients (−0.62% vs. −1.57%; p = 0.001). GLP-1 RAs provide superior glucose-lowering effects in insulin-treated patients compared with non-insulin-treated patients with T2D without significant differences in body weight decrease.
STUDY OF YOUNG MOTORCYCLISTS’ RISK BEHAVIOURS TOWARDS ROAD ACCIDENTS IN KUANTAN

In Malaysia, the number of motorcycle-related traffic accidents has gradually climbed over time. Road traffic accidents are typically caused by a combination of individuals and environmental circumstances.Young motorcyclists had significantly over-represented number of deaths in motorcycle road accidents. Many aspects, such as inexperience, lack of riding competence, and risky riding behaviour, have been linked to road traffic crashes among young adults aged 16 to 19 years old. However, less study has been conducted to analyze these young motorcyclists (high school students) riding behaviour. Therefore, this review aims to identify secondary school student’s risk behaviours for road traffic accidents among motorcyclists in Kuantan with young motorcyclists being the main contributor to the road accidents. Most of the youngster use motorcycles as their daily mode of transportation. Methods: This study used a cross-sectional study design and a simple random sampling method. It was conducted among students in three different school in Kuantan area. This study used on-site behavioural observation survey which data observation forms are specifically designed to collect data on motorcyclists’ risk behaviours by using a video camera in the school area. Results: The findings proved that the male students had higher frequency number that contribute to break the speed limits behaviour compare to the female students. Subsequently, breaking the speed limit and riding without crash helmets, failing to keep proper side to side movement with another vehicle and tailgating with another vehicle with unsafe distance are the most influenced risk riding behaviour factors among the students. Apart from that, riding while impaired, performing stunting acts, riding against traffic and riding without headlights on & traffic violation are the behaviours that less contributed to the number of motorcycle accidents. Conclusion: Each risky riding behavior factor has a different effect on road safety among young mototcyclists, especially the students in urban areas. Other than that, the estimated number of crashes can be a reference to authority to reduce the number of accidents in Malaysia.
Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery

Microneedles are minimally invasive systems that can deliver drugs intradermally without pain and bleeding and can advantageously replace the hypodermal needles and oral routes of delivery. Deferasirox (DFS) is an iron chelator employed in several ailments where iron overload plays an important role in disease manifestation. In this study, DFS was formulated into a nanosuspension (NSs) through wet media milling employing PVA as a stabilizer and successfully loaded in polymeric dissolving microneedles (DMNs). The release studies for DFS-NS clearly showed a threefold increased dissolution rate compared to pure DFS. The mechanical characterization of DFS-NS-DMNs revealed that the system was sufficiently strong for efficacious skin penetration. Optical coherence tomography images confirmed an insertion of up to 378 µm into full-thickness porcine skin layers. The skin deposition studies showed 60% drug deposition from NS-DMN, which was much higher than from the DFS-NS transdermal patch (DFS-NS-TP) (without needles) or pure DFS-DMNs. Moreover, DFS-NS without DMNs did not deposit well inside the skin, indicating that DMNs played an important role in effectively delivering drugs inside the skin. Therefore, it is evident from the findings that loading DFS-NS into novel DMN devices can effectively deliver DFS transdermally.
Administration of Ligilactobacillus salivarius CECT 30632 to elderly during the COVID-19 pandemic: Nasal and fecal metataxonomic analysis and fatty acid profiling

Elderly was the most affected population during the first COVID-19 and those living in nursing homes represented the most vulnerable group, with high mortality rates, until vaccines became available. In a previous article, we presented an open-label trial showing the beneficial effect of the strain Ligilactobacillus salivarius CECT 30632 (previously known as L. salivarius MP101) on the functional and nutritional status, and on the nasal and fecal inflammatory profiles of elderly residing in a nursing home highly affected by the pandemic. The objective of this post-hoc analysis was to elucidate if there were changes in the nasal and fecal bacteriomes of a subset of these patients as a result of the administration of the strain for 4 months and, also, its impact on their fecal fatty acids profiles. Culture-based methods showed that, while L. salivarius (species level) could not be detected in any of the fecal samples at day 0, L. salivarius CECT 30632 (strain level) was present in all the recruited people at day 120. Paradoxically, the increase in the L. salivarius counts was not reflected in changes in the metataxonomic analysis of the nasal and fecal samples or in changes in the fatty acid profiles in the fecal samples of the recruited people. Overall, our results indicate that L. salivarius CECT 30632 colonized, at least temporarily, the intestinal tract of the recruited elderly and may have contributed to improvements in their functional, nutritional, and immunological status, without changing the general structure of their nasal and fecal bacteriomes when assessed at the genus level. They also suggest the ability of low abundance bacteria to train immunity.
THE ROLE OF CARTILAGE INTERMEDIATE LAYER PROTEIN2 (CILP2) IN EVALUATING THE EFFECT OF TREATMENTS (PLATELET-RICH PLASMA AND HYALURONIC ACID) ON PATIENTS WITH EARLY KNEE OSTEOARTHRITIS

Background: Cartilage intermediate layer protein 2 (CILP2) is a monomeric glycoprotein that is mostly expressed in the intermediate zone of articular cartilage and can be detected in the extracellular matrix (ECM). The level of CILP2 in serum and its quantity on the articular cartilage surface and throughout the articular cartilage indicates the potential utility of CILP2 for investigation as a biomarker for determining cartilage deterioration in joint disorders. The CILP2 measurement of changes in cartilage biomarkers may be an effective and sensitive tool for detecting the early development of knee osteoarthritis (KOA) in people at risk for KOA. Changes in CILP2 levels may be beneficial for the early diagnosis of KOA, as CILP2 appears to be linked to cartilage thickness reduction in people who are more likely to develop KOA. Platelet rich plasma (PRP) effectiveness of transforming growth factor, platelet-derived growth factor, and the vascular endothelial growth factor is thought to be related to their release. Because of their capacity to increase matrix formation,growth factors have been widely researched for OA and cartilage regeneration. Hyaluronic acid (HA) is a glycosaminoglycan
Evaluando la efectividad del aula invertida y de un laboratorio virtual para alumnos de educación básica durante la pandemia

La pandemia de covid-19 ha provocado la incorporación de novedosos métodos de enseñanza, tal es el caso de la estrategia del aula invertida, la cual, mediante la incorporación de elementos de videoconferencia y lecturas previas, permite transmitir el conocimiento con mayor flexibilidad y que el alumno se apropie de este. Este estudio investiga los efectos del aula invertida desde la percepción de estudiantes de educación básica durante la pandemia actual. La muestra estuvo compuesta por 16 estudiantes entre los 9 y 10 años de edad que cursaban el periodo académico 2020-2021 (Tolcayuca, Hidalgo, México). Se administraron y examinaron encuestas idénticas a través de estadísticas descriptivas y pruebas no paramétricas. Se encontraron diferencias estadísticamente significativas entre las pruebas previas y posteriores: los estudiantes mejoraron en las últimas. La mayoría de los estudiantes tuvo una percepción positiva sobre el aula invertida; se destaca la ventaja de las actividades prácticas en clase, así como una mayor autonomía en el aprendizaje.
Large-scale coherent turbulence structures in a compressible mixing layer flow

Detailed flow visualization experiments were carried out in a self-similar turbulent mixing layer at a nominal convective Mach number of 1.1. The flow visualization technique was base on Rayleigh scattering from nanometer-scale contaminant particles present in the freestream flow. The interface marked by the vaporization of the particles revealed the large-scale organized turbulence structures in the mixing layer. Quantitative measures of the length scale, orientation, and speed of organized structures were derived from the flow visualization data, and were found to agree well with conventional point-probe measurements.
Error Bounds for Piecewise Convex Quadratic Programs and Applications

In this paper, we establish a local error estimate for feasible solutions of a piecewise convex quadratic program and a global error estimate for feasible solutions of a convex piecewise quadratic program. These error estimates provide a unified approach for deriving many old and new error estimates for linear programs, linear complementarity problems, convex quadratic programs, and affine variational inequality problems. The approach reveals the fact that each error estimate is a consequence of some reformulation of the original problem as a piecewise convex quadratic program or a convex piecewise quadratic program. In a sense, even Robinson's result on the upper Lipschitz continuity of a polyhedral mapping can be considered as a special case of error estimates for approximate solutions of a piecewise convex quadratic program. As an application, we derive new (global) error estimates for iterates of the proximal point algorithm for solving a convex piecewise quadratic program.
Updating knowledge in estimating the genetics parameters: Multi-trait and Multi-Environment Bayesian analysis in rice

: Among the multi-trait models selected to study several traits and environments jointly, the Bayesian framework has been a preferred tool when constructing a more complex and biologically realistic model. In most cases, non-informative prior distributions are adopted in studies using the Bayesian approach. However, the Bayesian approach presents more accurate estimates when informative prior distributions are used. The present study was developed to evaluate the efficiency and applicability of multi-trait multi-environment (MTME) models within a Bayesian framework utilizing a strategy for eliciting informative prior distribution using previous data on rice. The study involved data pertaining to rice ( Oryza sativa L.) genotypes in three environments and five crop seasons (2010/2011 until 2014/2015) for the following traits: grain yield (GY), flowering in days (FLOR) and plant height (PH). Variance components, genetic and non-genetic parameters were estimated using the Bayesian method. In general, the informative prior distribution in Bayesian MTME models provided higher estimates of individual narrow-sense heritability and variance components, as well as minor lengths for the highest probability density interval (HPD), compared to their respective non-informative prior distribution analyses. More informative prior distributions make it possible to detect genetic correlations between traits, which cannot be achieved with non-informative prior distributions. Therefore, this mechanism presented to update knowledge for an elicitation of an informative prior distribution can be efficiently applied in rice breeding programs.
The Financial Signaling And Internal Factor Company Against To Earning Per Share

This research aims to determine the results of financial signal testing as indicated by return on equity (ROE) and liquidity and then the internal company as indicated by company size and audit quality on earnings per share (EPS). The research method used is quantitative. The population of this study is consumer goods companies, totaling 180 companies listed on the Indonesia Stock Exchange (IDX) during 2018-2021. The sample selection technique uses purposive sampling. The data analysis technique uses multiple linear regressions with the IBM SPSS 25 tool. The results show that return on equity, firm size and audit quality affect earnings per share. However, liquidity does not affect earnings per share. This research can be a source of reference for further research. Then it can also be a source of reference for companies in improving financial performance in maintaining the company's existence in the capital market and the maximum consistency of business development to satisfy the principles.
Impact of Dietary Arachidonic Acid on Gut Microbiota Composition and Gut–Brain Axis in Male BALB/C Mice

Although arachidonic acid (ARA) is the precursor of the majority of eicosanoids, its influence as a food component on health is not well known. Therefore, we investigated its impact on the gut microbiota and gut–brain axis. Groups of male BALB/c mice were fed either a standard diet containing 5% lipids (Std-ARA) or 15%-lipid diets without ARA (HL-ARA) or with 1% ARA (HL + ARA) for 9 weeks. Fatty acid profiles of all three diets were the same. The HL-ARA diet favored the growth of Bifidobacterium pseudolongum contrary to the HL + ARA diet that favored the pro-inflammatory Escherichia–Shigella genus in fecal microbiota. Dietary ARA intake induced 4- and 15-fold colic overexpression of the pro-inflammatory markers IL-1β and CD40, respectively, without affecting those of TNFα and adiponectin. In the brain, dietary ARA intake led to moderate overexpression of GFAP in the hippocampus and cortex. Both the hyperlipidic diets reduced IL-6 and IL-12 in the brain. For the first time, it was shown that dietary ARA altered the gut microbiota, led to low-grade colic inflammation, and induced astrogliosis in the brain. Further work is necessary to determine the involved mechanisms.