Miracle-dz/UniFAR-FTUs huggingface dataset:
BCTT_A_289014 107..132

1Pharmacy Department, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia; 2Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; 3Ben Franklin TB Control Program, Columbus, OH, USA; 4Ohio State Global One Health Initiative, Office of International Affairs, The Ohio State University, Addis Ababa, Ethiopia Purpose: The study aimed to evaluate the quality of life patterns and the effects of AC and AC-T chemotherapy’s toxicities on QoL among Ethiopian women with breast cancer. Methods: QoL was measured at baseline and at every end of two cycles, for the median of 8 cycles among 146 breast cancer women on AC and AC-T chemotherapy, using EORTC QLQ-C30 and BR23 instruments. The effect of QoL score, socio-demographic, and clinical variables at baseline were adjusted for the effect of chemotherapy’s toxicities on QoL. Results: Overall QoL, all functional scales (except cognitive functioning, body image, future perspectives, and sexual functioning) and symptom scales (except dyspnea, insomnia, pain score, arm, and breast symptoms) of EORTC QLQ-C30 and BR23 deteriorated significantly both clinically and statistically, in particular, during the first two cycles of chemotherapy. After the end of cycle 2 or 4, except for cognitive, social functioning, and financial difficulties of the patients, almost all other QoL dimensions were improved towards pretreatment score by the end of cycle 8. In addition to age, educational status, and tumor stage, the Global Health Status (−10.55≤B≤−7.71, P≤0.013), and the functional scales (−25.320≤B≤−6.351, P≤0.033) of EORTC QLQ-C30 and BR23 were significantly affected at least by one of the AC and AC-T chemotherapy’s toxicity such as grade≥2 fatigue, dysgeusia, constipation, dry mouth, vomiting, oral mucositis, skin hyperpigmentation and/ or peripheral neuropathy than their lower grade. Grade≥2 fatigue, dysgeusia, oral mucositis, constipation, peripheral neuropathy, anemia arthralgia/myalgia, dry mouth, diarrhea, constipation, and/or skin hyperpigmentation were positively predicted for the deterioration of symptoms scale of EORTC QLQ-C30 and BR23 (4.819≤B≤26.451, P≤0.043). Conclusion: Quality of life among Ethiopian breast cancer patients on AC and AC-T regimens significantly deteriorated particularly during the first two cycles of chemotherapy. In addition to the age, tumor stage and educational status of the patients, grade≥2 fatigue, dysgeusia, constipation, oral mucositis, dry mouth, peripheral neuropathy, and skin hyperpigmentation due to AC and AC-T chemotherapy were frequently associated with deterioration of different scales/items QoL. Hence, devising different strategies to improve the deteriorated QoL due to chemotherapy’s toxicities particularly during the first two cycles has paramount importance.
Cognitive ^ behavioural therapy for substance use disorders in people with psychotic disorders Randomised controlled trial

Declaration of interest None. Funding is detailed in Acknowledgements. Few randomised controlled trials (RCTs) have been targeted at reducing substance use among people with psychotic disorders. Two large RCTs have reported encouraging but short-term effects of single-session motivational interventions among psychiatric hospital in-patients with mixed diagnoses and coexisting alcohol and/or other drug use problems (Baker et al, 2002; Hulse & Tait, 2003). In a pilot study of 25 in-patients with early psychosis, Kavanagh et al (2004) reported that a total of 3 hours’ motivational interviewing resulted in significantly better outcomes. Cognitive–behavioural therapy (CBT) has been shown to be effective for problems associated with alcohol (Shand et al, 2003), cannabis (Copeland et al, 2001) and amphetamine use (Baker et al, 2005a), for improving psychotic symptomatology (Haddock et al, 2003) and in related service contexts (Graham et al, 2004). In the first RCT to investigate the efficacy of CBT among people with coexisting schizophrenia and substance use disorder, Barrowclough et al (2001) reported modest yet promising findings. Eighteen months after study entry, the treatment group had superior general functioning and negative symptom scores, but there was no differential effect on percentage of days of abstinence from substances (Haddock et al, 2003). The authors suggested that larger studies are required that examine the efficacy of the different components of CBT interventions. The aim of the present study was to investigate whether a 10-session motivational interviewing/CBT intervention administered to a relatively large sample of people with psychosis and substance use disorders was more efficacious than routine treatment in reducing substance use and improving symptomatology and general functioning.
Gas Separation Performance of a Hollow-Filament Type Polyimide Membrane Module for a Compact Tritium Removal System

A new tritium removal system using gas separation membranes has been studied to develop more compact and cost-effective system for a fusion reactor. To obtain necessary parameters, which are directly scale able to the ITER Atmospheric Detritiation System, the basic tritium recovery performance was investigated with a scaled polyimide membrane module ( hollow-filament type: 10 m 3 /hr ) loop. The result shows that the H 2 recovery ratio from N 2 or Air was more than 99 % or about 97 %, respectively, at flow rate ratio of permeated/feed = 0.1, feed & permeated side pressures = 2580 & 80 torr, and module temp. = 293 K. Tritium (HT) recovery function was almost the same of H 2 recovery, even though the total hydrogen concentration was a few ppm in the feed of module. H 2 0 recovery performance was better than hydrogen recovery. These recovery functions were improved effectively decreasing the pressure ratio of permeated/feed of module.
LYMPHOID NEOPLASIA Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia

Adult T-cell leukemia (ATL) is an aggressive malignancy of CD4 1 lymphocytes caused by human T-cell lymphotropic virus type 1. Currently, there is no accepted curativetherapy for ATL.In geneexpression profiling, theantiapoptotic proteinsurvivin (BIRC5) demonstrated a striking increase in ATL, and its expression was increased in patient ATL cells resistant to the anti-CD52 monoclonal antibody alemtuzumab (Campath-1H). In this study, we investigated the antitumor activity of a small-molecule survivin suppressant YM155 alone and in combination with alemtuzumab in a murine model of human ATL (MET-1). Both YM155 alone and its combination with alemtuzumab demonstrated therapeutic efficacy by lowering serum soluble IL-2R a (sIL-2R a ) levels ( P < .001) and prolonged the survival of tumor-bearing mice ( P < .0001). Moreover, the combination of YM155 with alemtuzumab demonstrated markedly additive antitumor activity by significantly lowering serum sIL-2R a levels and improving the survival of leukemia-bearing mice compared with monotherapy with either YM155 ( P < .001) or alemtuzumab ( P < .05). More significantly, all mice that received the combination therapy survived and were tumor free > 6 months after treatment. Our data support a clinical trial of the combination of YM155 with alemtuzumab in ATL. This trial was registered at www.clinicaltrials. gov as #NCT00061048. ( Blood . 2013;121(11):2029-2037)
A spectral atlas of the Herbig Ae star AB Aurigae. The visible domain from 391 to 874 nm

The visible spectrum of the pre-main-sequence Herbig Ae star AB Aur (A0Ve), recorded by the MUSICOS echelle spectrograph, was used to elaborate a high resolution (R = 38000) spectral atlas, with line identification, in the wavelength range 391-874 nm. The numerous spectral features were individually measured and their identification was carried out with the help of a synthetic spectrum and a laboratory wavelength list for relevant atomic species. For 120 spectral features present in the spectrum, we identified contributions from about 215 lines. The presence of 19 ions from 15 different elements is firmly established. From the analysis of several well-defined photospheric lines, we determined for AB Aur a vsini value of 80 ± 5 kms −1
Stability and stabilization

Volume One: Modeling and estimation. General introduction. Physical modeling. Bond-graph modeling of physical systems. Identifiability and nonlinearities. Identification and realization by state affine models. Observability and observers. Index. Volume Two: Stability and stabilization. Preface. General introduction. Asymptotic behaviour of noncontroled systems. Stability, stabilization, regulation using vectorial norms. Robust stabilization of systems with perturbed dynamics. Stability and control of linear systems with saturations. Annexes. Volume Three: Control. Preface. General introduction. First order control of nonlinear systems. Input-output linearization. A graph-theoric approach to input-output decoupling and linearization. Static and dynamic state feedback linearization. On nonlinear digital control. Applications of input-output linearization and decoupling under static feedback. Approximate closed loop optimization of nonlinear systems using singular perturbation methodology. Annexes. Index.
Risk factors for early readmission after acute exacerbation of chronic obstructive pulmonary disease CURRENT

Background Patients (COPD) are at high risk for readmission. We aimed to identify the prevalence and risk factors for readmission. Methods We included 16,105 patients who had claimed their medical expenses from May 1, 2014, to May 1, 2016 after discharge from any medical facility in Korea, following treatment for acute exacerbation of COPD. We analysed the potential risk factors for readmission within 30 days of discharge. Results Readmission rate was 26.4% (3989 patients among 15,101 patients) and over 50% of readmissions occurred within 10 days of discharge. Approximately 57% of readmissions occurred due to respiratory causes. Major causes of readmission were COPD (27%), pneumonia (14.2%) and lung cancer (7.1%), in that order. Patients who were readmitted were male, had more comorbidities, and were less frequently admitted to tertiary hospitals than those who were not readmitted. Risk factors for readmission within 30 days of discharge were male sex, medical aid coverage, longer hospital stay, longer duration of systemic steroid use during hospital stay, high comorbid condition index, and discharge to skilled nursing facility. occurred in approximately a quarter patients, and was associated with patient-related and clinical factors. Using these results, we can identify high-risk patients for readmission and precautions are needed to be taken before deciding discharge plan. Further research is needed to develop accurate tools for predicting the risk of readmission before discharge and development and evaluation of an effective care programs for COPD patients are necessary. results for association between corticosteroids and early readmission in AECOPD patients, by showing that corticosteroid use for more than 5 days was associated with an increased risk of rehospitalisation. Our results correspond to recent meta-analysis results and recommendations that long-term corticosteroid use during hospitalisation has no benefit compared with short-term use[27].
PERCEPTION OF DIABETES MANAGEMENT AND CARDIOVASCULAR DISEASE RISK AMONG ADULTS POPULATION WITH PREDIABETES IN NORTH-WEST RAJASTHAN

The aim of this study was to explore the perception and understanding of adults with prediabetes about their illness control, risk for CVD and their adherence to healthcare management plans in community. Design: This was a hospital based cross sectional study.Methods: Prediabetic subjects was identied rst degree relatives of type 2 DM Patients, enrolled in diabetic research centre hospital Bikaner.Data were collected in approximately 6 to 10 months semi-structured interviews and analysed using content analysis. Results: Data analysis revealed four themes: (a) Perception of diabetes control; (b) Perception of cardiovascular disease risk; (c) Coping with disease-imposed limitations; and (d) Information validation. Conclusion: The study concludes that the perception of disease control does not necessarily coincide with actual disease control. Examining patients with prediabetes perception and knowledge of their healthcare management and increased CVD risks is essential. An individualized culture and gender-sensitive health education and counselling involving spouses are recommended. Social media to disseminate scientic valid health instructions can enhance adherence. Clinically relevant biochemical & hematological parameters may play a role in the early development of type 2 diabetes. Further research is necessary to study the gender-specic contribution of hematological parameters to the pathogenesis of prediabetic states and nally to the manifestation of type 2 diabetes.
Financially Qualiﬁed Members in an Upper Echelon and Their Relationship with Corporate Sustainability: Evidence from an Emerging Economy

: Non-observable board diversity is an important organizational strategy for improving the long-term growth and survivability of ﬁrms. The involvement of corporate sustainability (CS) in top management teams has led to effective boards. By using agency theory, we stress how ﬁnancially qualiﬁed directors (FQD) in audit committees (ACs) may positively or negatively affect the practice of earnings management (EM). We also use various theories to explain how a powerful chief executive ofﬁcer (CEO) complicates the effectiveness of AC and reduces their ability to detect EM practices. Using a sample of 1020 ﬁrm-year observations representing 204 non-ﬁnancial listed Pakistani ﬁrms during 2013–2017, we ﬁnd that the presence of FQD on the AC is associated with lower levels of EM. Our analysis shows that this effect is driven by the level of FQDs’ accounting knowledge.
Novel insights into the Thaumarchaeota in the deepest oceans: their metabolism and potential adaptation mechanisms CURRENT STATUS:

Background: Marine Group I (MGI) Thaumarchaeota , which play key roles in the global biogeochemical cycling of nitrogen and carbon (ammonia oxidizers), thrive in the aphotic deep sea with massive populations. Recent studies have revealed that MGI Thaumarchaeota were present in the deepest part of oceans - the hadal zone (depth > 6,000 m, consisting almost entirely of trenches), with the predominant phylotype being distinct from that in the “shallower” deep sea. However, little is known about the metabolism and distribution of these ammonia oxidizers in the hadal water. Results: In this study, metagenomic data were obtained from 0-10,500 m deep seawater samples from the Mariana Trench. The distribution patterns of Thaumarchaeota derived from metagenomics and 16S rRNA gene sequencing were in line with that reported in previous studies: abundance of Thaumarchaeota peaked in bathypelagic zone (depth 1,000 – 4,000 m) and the predominant clade shifted in the hadal zone. Several metagenome-assembled thaumarchaeotal genomes were recovered, including a near-complete one representing the dominant hadal phylotype of MGI. Using comparative genomics we predict that unexpected genes involved in bioenergetics, including two distinct ATP synthase genes (predicted to be coupled with H + and Na + respectively), and genes horizontally transferred from other extremophiles, such as those encoding putative di- myo -inositol-phosphate (DIP) synthases, might significantly contribute to the success of this hadal clade under the extreme condition. We also found that hadal MGI have the genetic potential to import a far higher range of organic compounds than their shallower water counterparts. Despite this trait, hadal MDI ammonia oxidation and carbon fixation genes are highly transcribed providing evidence they are likely autotrophic, contributing to the primary production in the aphotic deep sea. Conclusions: Our study reveals potentially novel adaptation mechanisms of deep-sea thaumarchaeotal clades and suggests key functions of deep-sea Thaumarchaeota in carbon and nitrogen cycling. participating inorganic carbon fixation in these archaea from > 10 km deep Challenger Deep samples, within the Mariana Trench, Earth’s oceans deepest known site. Comparative genomic approaches were employed to determine the potential mechanisms required for the success of this unique archaeal clade in such an extreme trench environment and the transcriptional activity of the mechanisms were confirmed. This study therefore provides a new perspective on the adaptation Alam I, Rashid M, Ba-Alawi W, Zhang G, et al. Comparative genomics reveals adaptations of a halotolerant thaumarchaeon in the interfaces of
Social, Reproductive and Contextual Inﬂuences on Fecal Glucocorticoid Metabolites in Captive Yangtze Finless Porpoises ( Neophocaena asiaeorientalis asiaeorientalis ) and Bottlenose Dolphins (

: Although the use of fecal glucocorticoid metabolite (FGCM) measurements as non-invasive biomarkers for the stress response in mammals has increased, few studies have been conducted in odontocetes. We investigated if animal sex, age, pregnancy or contextual variations (season, sampling time, enrichment, social separation and presence of visitors) inﬂuenced the FGCM concentrations in presumably healthy, captive and endangered Yangtze ﬁnless porpoises (YFPs, N = 4) and bottlenose dolphins (BDs, N = 3). For YFPs, the FGCM concentrations were inﬂuenced by season ( p = 0.01), diurnal variation ( p = 0.01) and pregnancy ( p = 0.005). Contextual variables that were associated with increases in FGCM concentrations included social separations ( p = 0.003) and numbers of visitors ( p = 0.0002). Concentrations of FGCMs were lower ( p = 0.001) after exposure to environmental enrichment. For BDs, enrichment was associated with reduced concentrations of FGCMs ( p < 0.0001). The presence of visitors also inﬂuenced this species’ FGCM concentrations ( p = 0.006). These results demonstrate that changes in the FGCM concentrations in YFPs and BDs may occur in response to contextual and social changes. In combination with other behavioral and physiological assessments, measurements of FGCMs may be a useful tool for monitoring cetacean welfare. Such monitoring may help researchers identify and better understand situations that may be stressful for animals and, therefore, improve management and husbandry. Furthermore, results from our study and inferences of the FGCM concentrations in cetaceans, and their potential relationship to stress, may be extrapolated to studies of free-ranging animals, which may help detect possible environmental or anthropogenic stressors that could be a ﬀ ecting these populations.
Evaluation of water quality parameters for monitoring natural, urban, and agricultural areas in the Brazilian Cerrado

: Introduction : Brazil’s Federal District (FD) has seen steep population growth in recent years, and this has increased demand for high-quality water. Aim :The present work aims to evaluate the quality of surface water from two water bodies in the FD at six sampling points, three of which are in the Sobradinho River (the receiving body of a sewage treatment plant effluent) and three in the Jardim River (located in an agricultural region). Methods : Analyses were carried out every thirty days, for twelve months, covering rainy and dry seasons. Parameters were analyzed such as temperature, pH, dissolved oxygen (DO), conductivity, turbidity, total hardness, main ions, total and fecal coliforms ( E. coli ) in water. Ecotoxicological evaluation was also performed, using the micro-crustacean Ceriodaphnia dubia . Results : Data of physical and chemical determinations showed DO, conductivity, Cl – , NO 3– , SO 42– and Na + to be important in indicating contamination by urban effluents. On the subject of biological parameters – E. coli and ecotoxicological evaluation - the former was seen to be more effective in the urban area. However, in the countryside, the assay with C. dubia proved to be the most sensitive, although less than ideal, because the organism is very sensitive to low water hardness. Conclusions : The fecal coliform indicator ( E. coli ) was the most effective one for comparing water quality in the two basins, mainly for the urbanized one, while ecotoxicity assays with C. dubia were harmed by the natural chemical composition of the water.
University of Birmingham Scaling of Early Social Cognitive Skills in Typically Developing Infants and Children with Autism Spectrum Disorder

We delineate the sequence that typically developing infants pass tasks that assess different early social cognitive skills considered precursors to theory-of-mind abilities. We compared this normative sequence to performance on these tasks in a group of autistic (AUT) children. 86 infants were administered seven tasks assessing intention reading and shared intentionality (Study 1). Infants responses followed a consistent developmental sequence, forming a four-stage scale. These tasks were administered to 21 AUT children (Study 2), who passed tasks in the same sequence. However, performance on tasks that required following others’ eye gaze and cooperating with others was delayed. Findings indicate that earlier-developing skills provide a foundation for later-developing skills, and difficulties in acquiring some early social cognitive skills in AUT children.
WHILE EXPERIENCING INSULIN PUMP THROUGH THE REMOTE-CONTROL SCHEME IN YOUNG RESPONDENTS BY DM ADVANCES GLYCEMIC MEASURE ALSO IMPROVES CASE FULFILLMENT

: Background: Insulin delivery triggered through the remote-control remains the progressive aspect through novel insulin pump schemes. Those remote-control pump schemes may additional advance glycemic measure in addition case fulfilment. The key purpose of our existing research was to measure possessions of progressive insulin pump scheme on respondents through type-1 DM. Methods: The forthcoming, observational research in 2 centers talked patients on numerous everyday inoculations converting to the combined pump arrangement (main: teenagers also undeveloped grownups, Secondary: school children). Behavior also case fulfillment limitations remained noted at starting point also at 2 appointments at 13 also 28 weeks. Results: Forty cases remained examined; primary n = 25 (average-age 17) also secondary n = 15 (average-age 10). From starting point to appointment 2, average reduction of HbA1c remained 2.08% (p = 0.00010) besides 0.80% (p = 0.08) for primary in addition, secondary set, individually. Respondent fulfilment degree remained satisfactory. Investigative examines exposed cases preferring exercise of remote-control attained greatest decreases in HbA1c (p = 0.0175). Security remained inspiring by not any opposing proceedings in phase from appointment 1 to appointment 2. Conclusions: Switching undeveloped Type 1 Diabetic Milieus cases from MDI to the remote-control-combined pump scheme attained by drops in HbA1c also insulin quantity. Optimistic defiance in the direction of remote functioning improved those belongings. Case gratification has decidedly enhanced.
Inhibits Poliovirus Uncoating

We investigated the mode of action of 6-(3,4-dichlorophenoxy-3-(ethylthio)-2-pyridincarbonitrile against poliovirus. This agent effectively blocked the synthesis of poliovirus proteins and RNA when it was added at the beginning of infection. Poliovirus attachment and internalization into HeLa cells were not inhibited in the presence of the compound; poliovirus uncoating was the target of its activity.