Miracle-dz/UniFAR-FTUs huggingface dataset:
One-point versus two-point fixation in the management of zygoma complex fractures

Background The treatment of zygoma complex fractures is of crucial importance in the field of plastic surgery. However, surgical methods to correct zygoma complex fractures, including the number of fixation sites, differ among operators. Although several studies have compared two-point and three-point fixation, no comparative research has yet been conducted on one-point versus two-point fixation using computed tomography scans of surgical results. Therefore, the present study aimed to address this gap in the literature by comparing surgical results between one-point and two-point fixation procedures. Methods In this study, we randomly selected patients to undergo surgery using one of two surgical methods. We analyzed patients with unilateral zygoma complex fractures unaccompanied by other fractures according to whether they underwent one-point fixation of the zygomaticomaxillary buttress or two-point fixation of the zygomaticomaxillary buttress and the zygomaticofrontal suture. We then made measurements at three points—the zygomaticofrontal suture, inferior orbital wall, and malar height—using 3-month postoperative computed tomography images and performed statistical analyses to compare the results of the two methods. Results All three measurements (zygomaticofrontal suture, inferior orbital wall, and malar height) showed significant differences (p<0.05) between one-point and two-point fixation. Highly significant differences were found for the zygomaticofrontal suture and malar height parameters. The difference in the inferior wall measurements was less meaningful, even though it also reached statistical significance. Conclusion Using three parameters in a statistical analysis of imaging findings, this study demonstrated significant differences in treatment outcomes according to the number of fixations. The results indicate that bone alignment and continuity can be achieved to a greater extent by two-point fixation instead of one-point fixation.
Hardware-in-Loop Comparison of Physiological Closed-Loop Controllers for the Autonomous Management of Hypotension

Trauma and hemorrhage are leading causes of death and disability worldwide in both civilian and military contexts. The delivery of life-saving goal-directed fluid resuscitation can be difficult to provide in resource-constrained settings, such as in forward military positions or mass-casualty scenarios. Automated solutions for fluid resuscitation could bridge resource gaps in these austere settings. While multiple physiological closed-loop controllers for the management of hypotension have been proposed, to date there is no consensus on controller design. Here, we compare the performance of four controller types—decision table, single-input fuzzy logic, dual-input fuzzy logic, and proportional–integral–derivative using a previously developed hardware-in-loop test platform where a range of hemorrhage scenarios can be programmed. Controllers were compared using traditional controller performance metrics, but conclusions were difficult to draw due to inconsistencies across the metrics. Instead, we propose three aggregate metrics that reflect the target intensity, stability, and resource efficiency of a controller, with the goal of selecting controllers for further development. These aggregate metrics identify a dual-input, fuzzy-logic-based controller as the preferred combination of intensity, stability, and resource efficiency within this use case. Based on these results, the aggressively tuned dual-input fuzzy logic controller should be considered a priority for further development.
A Retrospective Cohort Study Evaluating the Use of the Modified Early Warning Score to Improve Outcome Prediction in Neurosurgical Patients

Introduction The modified early warning score (mEWS) has been used to identify decompensating patients in critical care settings, potentially leading to better outcomes and safer, more cost-effective patient care. We examined whether the admission or maximum mEWS of neurosurgical patients was associated with outcomes and total patient costs across neurosurgical procedures. Methods This retrospective cohort study included all patients hospitalized at a quaternary care hospital for neurosurgery procedures during 2019. mEWS were automatically generated during a patient’s hospitalization from data available in the electronic medical record. Primary and secondary outcome measures were the first mEWS at admission, maximum mEWS during hospitalization, length of stay (LOS), discharge disposition, mortality, cost of hospitalization, and patient biomarkers (i.e., white blood cell count, erythrocyte sedimentation rate, C-reactive protein, and procalcitonin). Results In 1,408 patients evaluated, a mean first mEWS of 0.5 ± 0.9 (median: 0) and maximum mEWS of 2.6 ± 1.4 (median: 2) were observed. The maximum mEWS was achieved on average one day (median = 0 days) after admission and correlated with other biomarkers (p < 0.0001). Scores correlated with continuous outcomes (i.e., LOS and cost) distinctly based on disease types. Multivariate analysis showed that the maximum mEWS was associated with longer stay (OR = 1.8; 95% CI = 1.6-1.96, p = 0.0001), worse disposition (OR = 0.82, 95% CI = 0.71-0.95, p = 0.0001), higher mortality (OR = 1.7; 95% CI = 1.3-2.1, p = 0.0001), and greater cost (OR = 1.2, 95% CI = 1.1-1.3, p = 0.001). Machine learning algorithms suggested that logistic regression, naïve Bayes, and neural networks were most predictive of outcomes. Conclusion mEWS was associated with outcomes in neurosurgical patients and may be clinically useful. The composite score could be integrated with other clinical factors and was associated with LOS, discharge disposition, mortality, and patient cost. mEWS also could be used early during a patient's admission to stratify risk. Increase in mEWS scores correlated with the outcome to a different degree in distinct patient/disease types. These results show the potential of the mEWS to predict outcomes in neurosurgical patients and suggest that it could be incorporated into clinical decision-making and/or monitoring of neurosurgical patients during admission. However, further studies and refinement of mEWS are needed to better integrate it into patient care.
Demodicosis as a Skin Complication in Organ Transplant Recipients: A Case Series

Case series Patients: Male, 79-year-old • Male, 64-year-old • Male, 70-year-old • Male, 68-year-old Final Diagnosis: Demodicosis Symptoms: Itch • papular skin lesion • telangiectasiae Medication: — Clinical Procedure: — Specialty: Dermatology • Transplantology Objective: Rare coexistence of disease or pathology Background: Patients after organ transplantation are, due to chronic immunosuppression, prone to have many cutaneous adverse events, both infections and neoplasms. Studies show that some groups of patients under chronic immunosuppression are prone to develop demodicosis. The significance of demodicosis in the population of organ transplant recipients has not been established yet. Case Reports: We present 4 cases of patients with multiply dermatological complications of immunosuppression, in which one of them is demodicosis. The presented symptoms were itch, pustules, papules, and/or telangiectasias. Age of patients varied from 64 to 79 years old. Time between transplantation and diagnosis of demodicosis varied from 6 to 10 years. Other dermatological problems that appeared were basal cell carcinoma, actinic keratosis, and seborrheic keratosis. Patients showed complete resolution after treatment with topical ivermectin 10 mg/g and topical permethrin 50 mg/g. However, the medications were prolonged to 16 weeks in 1 case to reduce persistent papules and telangiectasias. The therapy did not cause any complications or disruptions in function of transplanted kidneys in any of reported patients. Conclusions: Demodicosis may have a significant role in the group of infections that organ transplant recipients are prone to, and may co-exist with other dermatological diseases, including neoplasms. However, larger studies in the field are needed.
ER Stress Response and Induction of Apoptosis in Malignant Pleural Mesothelioma: The Achilles Heel Targeted by the Anticancer Ruthenium Drug BOLD-100

Simple Summary Malignant mesothelioma is a rare cancer arising from the serosal surfaces of the body, mainly from the pleural layer. This cancer, strongly linked to asbestos exposure, shows a very inauspicious prognosis. In fact, there is no efficient therapeutic treatment for malignant pleural mesothelioma (MPM). Thus, there is an urgent need to develop novel therapeutic approaches to treat this form of cancer. Our previous study showed the importance of GRP78 in MPM survival. BOLD-100 is a specific modulator of GRP78 and we have observed that it shows cytotoxicity against MPM cells. In particular, we describe that BOLD-100 increases oxidative stress and deregulates the calcium homeostasis leading to cell stress and, ultimately, to cell death. Our in vitro data strongly suggest that BOLD-100 inhibits the growth of MPM cell lines, proposing the application as a single agent, or in combination with other standard-of-care drugs, to treat MPM. Abstract Malignant mesothelioma is a rare cancer arising from the serosal surfaces of the body, mainly from the pleural layer. This cancer is strongly related to asbestos exposure and shows a very inauspicious prognosis, because there are scarce therapeutic options for this rare disease. Thus, there is an urgent need to develop novel therapeutic approaches to treat this form of cancer. To explore the biology of malignant pleural mesothelioma (MPM), we previously observed that MPM cell lines show high expression of the GRP78 protein, which is a chaperone protein and the master regulator of the unfolded protein response (UPR) that resides in the endoplasmic reticulum (ER). Based on our previous studies showing the importance of GRP78 in MPM, we observed that BOLD-100, a specific modulator of GRP78 and the UPR, shows cytotoxicity against MPM cells. Our studies demonstrated that BOLD-100 increases ROS production and Ca2+ release from the ER, leading to ER stress activation and, ultimately, to cell death. Our in vitro data strongly suggest that BOLD-100 inhibits the growth of MPM cell lines, proposing the application as a single agent, or in combination with other standard-of-care drugs, to treat MPM.
Radiation Pattern Reconfigurable MIMO Antenna With Practical DC Bias Network

This paper presents a radiation pattern reconfigurable (RPR) based multiple-input multiple-output (MIMO) antenna. The proposed antenna operates at 3.5 GHz for all switching conditions with S21 results of less than -20 dB. This work specifically focuses on implementing a practical DC bias network for the previously proposed RPR-MIMO antenna. The DC bias design is crucial where the tilt angle is slightly affected. This could be due to the isolation loss and insertion loss provided by the actual switch; and the DC bias lines that were constructed using a few DC blocking capacitors and RF chokes. Finally, a comprehensive analysis was carried out to examine the beam steering performance of the antenna when implemented with the DC bias network.
Hardware Co-Simulation of an Efficient Adaptive Filter based ECG Denoising System with Inbuilt Reference Generator

Ambulatory ECG monitoring is helpful for the early diagnosis of cardiac arrhythmia. However, the noise present in the ECG signal creates difficulties in ECG interpretation. Many artifact suppression methods are developed for the ambulatory ECG but are limited to software implementation due to high complexity. In this paper, a hybrid technique has been proposed with discrete wavelet transform (DWT) and an adaptive filter to denoise the ambulatory ECG signals. Further, the hardware architecture is designed using Xilinx System Generator and the hardware co-simulation is performed in a MATLAB-Simulink environment using the Virtex-7 FPGA. ECG signals from the MIT-BIH Arrhythmia database (mitdb) and Noise Stress Test Database (nstdb) are used for simulation and comparison. It shows that the proposed method gives on an average 18.17% more signal-to-noise ratio (SNR) improvement and 26.67% more mean square error (MSE) minimization compared to existing hybrid methods. The proposed hardware implementation shows 20.90% less hardware resources than the existing work. It occupies only 5.77% LUTs when implemented on the Virtex-7 FPGA.
Invariants of Finite Reflection Groups

Let K be a field of characteristic zero. Let V be an n-dimensional vector space over K and let S be the graded ring of polynomial functions on V. If G is a group of linear transformations of V, then G acts naturally as a group of automorphisms of S if we define The elements of S invariant under all γ ∈ G constitute a homogeneous subring I(S) of S called the ring of polynomial invariants of G.
Absence of Gut Microbiota Is Associated with RPE/Choroid Transcriptomic Changes Related to Age-Related Macular Degeneration Pathobiology and Decreased Choroidal Neovascularization

Studies have begun to reveal significant connections between the gut microbiome and various retinal diseases, including age-related macular degeneration (AMD). As critical supporting tissues of the retina, the retinal pigment epithelium (RPE) and underlying choroid play a critical role in retinal homeostasis and degeneration. However, the relationship between the microbiome and RPE/choroid remains poorly understood, particularly in animal models of AMD. In order to better elucidate this role, we performed high-throughput RNA sequencing of RPE/choroid tissue in germ-free (GF) and specific pathogen-free (SPF) mice. Furthermore, utilizing a specialized laser-induced choroidal neovascularization (CNV) model that we developed, we compared CNV size and inflammatory response between GF and SPF mice. After correction of raw data, 660 differentially expressed genes (DEGs) were identified, including those involved in angiogenesis regulation, scavenger and cytokine receptor activity, and inflammatory response—all of which have been implicated in AMD pathogenesis. Among lasered mice, the GF group showed significantly decreased CNV lesion size and microglial infiltration around CNV compared to the SPF group. Together, these findings provide evidence for a potential gut–RPE/choroidal axis as well as a correlation with neovascular features of AMD.
Exogenously Applied Sodium Nitroprusside Mitigates Lead Toxicity in Rice by Regulating Antioxidants and Metal Stress-Related Transcripts

Sustainable agriculture is increasingly being put in danger by environmental contamination with dangerous heavy metals (HMs), especially lead (Pb). Plants have developed a sophisticated mechanism for nitric oxide (NO) production and signaling to regulate hazardous effects of abiotic factors, including HMs. In the current study, we investigated the role of exogenously applied sodium nitroprusside (SNP, a nitric oxide (NO) donor) in ameliorating the toxic effects of lead (Pb) on rice. For this purpose, plants were subjected to 1.2 mM Pb alone and in combination with 100 µM SNP. We found that under 1.2 mM Pb stress conditions, the accumulation of oxidative stress markers, including hydrogen peroxide (H2O2) (37%), superoxide anion (O2−) (28%), malondialdehyde (MDA) (33%), and electrolyte leakage (EL) (34%), was significantly reduced via the application of 100 µM SNP. On the other hand, under the said stress of Pb, the activity of the reactive oxygen species (ROS) scavengers such as polyphenol oxidase (PPO) (60%), peroxidase (POD) (28%), catalase (CAT) (26%), superoxide dismutase (SOD) (42%), and ascorbate peroxidase (APX) (58%) was significantly increased via the application of 100 µM SNP. In addition, the application of 100 µM SNP rescued agronomic traits such as plant height (24%), number of tillers per plant (40%), and visible green pigments (44%) when the plants were exposed to 1.2 mM Pb stress. Furthermore, after exposure to 1.2 mM Pb stress, the expression of the heavy-metal stress-related genes OsPCS1 (44%), OsPCS2 (74%), OsMTP1 (83%), OsMTP5 (53%), OsMT-I-1a (31%), and OsMT-I-1b (24%) was significantly enhanced via the application of 100 µM SNP. Overall, our research evaluates that exogenously applied 100 mM SNP protects rice plants from the oxidative damage brought on by 1.2 mM Pb stress by lowering oxidative stress markers, enhancing the antioxidant system and the transcript accumulation of HMs stress-related genes.
Effect of Precipitates on the Mechanical Performance of 7005 Aluminum Alloy Plates

In this study, the strength, elongation, and fatigue properties of 7005 aluminum alloy plates with different configurations of precipitates were investigated by means of tensile tests, fatigue tests, and microstructural observation. We found that the number and size of GP zones in an alloy plate matrix increased and the distribution was more uniform after the aging time was extended from 1 h to 4 h at 120 °C, which led to a rise in both strength and elongation of alloy plates with the extending aging time. The fatigue life of the alloy plates shortened slightly at first, then significantly prolonged, and then shortened again with the aging time extending from 1 h to 192 h and a fatigue stress level of 185 MPa and stress ratio (R) = 0. After aging at 120 °C for 96 h, the precipitates in the alloy plate matrix were almost all metastable η′-phase particles, which had the optimal aging strengthening effect on the alloy matrix, and the degree of mismatch between the α-Al matrix and second-phase particles was the smallest; the fatigue crack initiation and propagation resistances were the largest, leading to the best fatigue performance of alloy plates, and the fatigue life of the aluminum plate was the longest, up to 1.272 × 106 cycles. When the aging time at 120 °C was extended to 192 h, there were a small number of equilibrium η phases in the aluminum plates that were completely incoherent with the matrix and destroyed the continuity of the aluminum matrix, easily causing stress concentration. As a result, the fatigue life of alloy plates was shortened to 9.422 × 105 cycles.
EHBP1L1 Frameshift Deletion in English Springer Spaniel Dogs with Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) or Neonatal Losses

Hereditary myopathies are well documented in dogs, whereas hereditary dyserythropoietic anemias are rarely seen. The aim of this study was to further characterize the clinical and clinicopathological features of and to identify the causative genetic variant for a dyserythropoietic anemia and myopathy syndrome (DAMS) in English springer spaniel dogs (ESSPs). Twenty-six ESSPs, including five dogs with DAMS and two puppies that died perinatally, were studied. Progressive weakness, muscle atrophy—particularly of the temporal and pelvic muscles—trismus, dysphagia, and regurgitation due to megaesophagus were observed at all ages. Affected dogs had a non-regenerative, microcytic hypochromic anemia with metarubricytosis, target cells, and acanthocytes. Marked erythroid hyperplasia and dyserythropoiesis with non-orderly maturation of erythrocytes and inappropriate microcytic metarubricytosis were present. Muscle biopsies showed centralized nuclei, central pallor, lipocyte infiltrates, and fibrosis, which was consistent with centronuclear myopathy. The genome sequencing of two affected dogs was compared to 782 genomes of different canine breeds. A homozygous frameshift single-base deletion in EHBP1L1 was identified; this gene was not previously associated with DAMS. Pedigree analysis confirmed that the affected ESSPs were related. Variant genotyping showed appropriate complete segregation in the family, which was consistent with an autosomal recessive mode of inheritance. This study expands the known genotype–phenotype correlation of EHBP1L1 and the list of potential causative genes in dyserythropoietic anemias and myopathies in humans. EHBP1L1 deficiency was previously reported as perinatally lethal in humans and knockout mice. Our findings enable the genetic testing of ESSP dogs for early diagnosis and disease prevention through targeted breeding strategies.
Understanding the Meaning-Making of Romantic Relationships among Emerging Adults after Parental Divorce

Pursuing a romantic relationship is one of the most important developmental aspects of emerging adults. With the increasing divorce rate in Indonesia, the authors were interested in exploring how emerging adults make sense of romantic relationships after parental divorce. Three participants and two significant others were interviewed in this present study, in which interpretive phenomenological analysis was used as the approach to interpreting the data. This study generated two themes that show how emerging adults make meaning of romantic relationships, namely as a source of fear and a source of support. This contradictory meaning-making relates to the experience the participants had during their parents' divorce process and what they learned from the media or their significant others. These, coupled with human agency and the need for love, encourage the participants to learn from their parents' mistakes, develop certain behavioural patterns, and continue to seek romantic relationships in their lives. This study shows how interaction between parents during a divorce process can shape the meaning-making and behaviour patterns in the child’s romantic relationships. Therefore, it is suggested that divorced parents build an open communication, show positive interactions, and minimize exposing their children to negative interactions during the divorce process.
Physical profiling of Rugby Union players: implications for talent development

The aim of this pilot study was to measure the validity and reliability of the Metabolic Fitness Index for Team Sports (MFITS) and the Rugby-Specific Repeated-Speed (RS 2 ) test. Twenty elite development and semi-professional rugby union forwards and half backs performed the MFITS and RS 2 test four days apart, and then repeated the testing protocols a further 9 and 13 days later respectively. The most reliable outcome measure for the MFITS was the 60-m sprint (Intraclass correlation coefficients ICC = 0.966; coefficient of variation CV = 1.1%), which may be attributed to the short test duration. The average sprint time was the most reliable outcome measure in the RS 2 test (ICC = 0.953; CV = 0.8%), which may be due to the reduction in variation associated with averaging measures. The relationship between the sprint and aerobic measures of the respective tests showed higher correlations (range r = 0.59 – 0.79) than the anaerobic measures (r ≈ 0.15), illustrating the 400-m run within the MFITS is not indicative of repeated sprint ability in the RS 2 test. The low sample size creates greater uncertainty with the correlations, thus further work with a greater sample size is required to be clear about the validity and reliability of these tests.