Miracle-dz/UniFAR-FTUs huggingface dataset:
Multimorbidity Patterns and Associations with Gait, Balance and Lower Extremity Muscle Function in the Elderly: A Cross-Sectional Study in Northwest China

Purpose Fall is a common geriatric syndrome leading to various adverse outcomes in the elderly. Gait and balance disorders and decreased lower extremity muscle function are the major intrinsic risk factors of falls, and studies suggested that they were closely related to the underlying chronic conditions. This study aimed to explore the patterns of multimorbidity and determine the associations of these multimorbidity patterns with gait, balance and lower extremity muscle function. Patients and Methods A cross-sectional survey of 4803 participants aged ≥60 years in Shaanxi Province, China was conducted and the self-reported chronic conditions were investigated. The 6-m walk test, timed-up-and-go test (TUG) and 5-sit-to-stand test (5-STS) were conducted to evaluate gait, balance, and lower extremity muscle function respectively. Latent class analysis was used to explore patterns of multimorbidity, and multivariate regression analysis was used to determine the associations of multimorbidity patterns with gait, balance, and lower extremity muscle function. Results Five multimorbidity patterns were identified: Degenerative Disease Class, Cardio-metabolic Class, Stroke-Respiratory-Depression Class, Gastrointestinal Class, and Very sick Class, and they were differently associated with gait and balance disorders and decreased lower extremity muscle function. In particular, the multimorbidity patterns of Degenerative Disease Class and Stroke-Respiratory-Depression Class were closely associated with all the three risk factors of falls. Conclusion There are significant differences in the impact of different multimorbidity patterns on the major intrinsic risk factors of falls in the elderly population, and appropriate multimorbidity patterns are closely related to the prediction of falls and can help to develop fall prevention strategies in the elderly.
Evaluation of anxiety disorder in patients with trigeminal neuralgia

Background: The aim of this cross-sectional study was to evaluate the relationship between anxiety levels and severity of trigeminal neuralgia (TN) disorder’s chronic orofacial pain during 2019–2020 in Shiraz Dental Faculty. Methods: In this study, patients with TN disorder who were referred to the Oral Medicine Department of Shiraz Dental Faculty were evaluated. Individuals were selected based on convenience sampling. Finally, 47 patients with TN were recruited in this study. Satisfaction with treatment was recorded based on controlling the patient’s pain, age, sex, and frequency of recurrence, and data were analyzed using SPSS18. The Chi-square test was used to compare the final results. A reliability of more than 95% was considered significant (P < 0.05). Results: According to the results, the mean ages of participants with TN and control groups were 56.89 ± 10.93 and 37.12 ± 9.55, respectively. The mean value of participants’ age was significantly different between the two evaluated groups (P < 0.0001). The anxiety of patients with TN was significantly higher than the healthy control group (P < 0.0001). The mean level of anxiety in patients with TN and also in healthy controls was not significantly different among men and women (P > 0.05). The mean level of anxiety of men and women in TN group was significantly higher than the healthy control women (P = 0.001). The mean levels of anxiety between different age ranges in patients with TN and healthy controls were not different in both evaluated groups (P > 0.05). Patients with TN in different age ranges had higher level of anxiety than healthy controls (P < 0.05). Conclusion: Patients with TN had significantly higher level of anxiety than healthy participants.
Raman Spectroscopy Combined with Malaria Protein for Early Capture and Recognition of Broad-Spectrum Circulating Tumor Cells

Early identification of tumors can significantly reduce the mortality rate. Circulating tumor cells (CTCs) are a type of tumor cell that detaches from the primary tumor and circulates through the bloodstream. Monitoring CTCs may allow the early identification of tumor progression. However, due to their rarity and heterogeneity, the enrichment and identification of CTCs is still challenging. Studies have shown that Raman spectroscopy could distinguish CTCs from metastatic cancer patients. VAR2CSA, a class of malaria proteins, has a strong broad-spectrum binding effect on various tumor cells and is a promising candidate biomarker for cancer detection. Here, recombinant malaria VAR2CSA proteins were synthesized, expressed, and purified. After confirming that various types of tumor cells can be isolated from blood by recombinant malaria VAR2CSA proteins, we further proved that the VAR2CSA combined with Raman spectroscopy could be used efficiently for tumor capture and type recognition using A549 cell lines spiked into the blood. This would allow the early screening and detection of a broad spectrum of CTCs. Finally, we synthesized and purified the malaria protein fusion antibody and confirmed its in vitro tumor-killing activity. Herein, this paper exploits the theoretical basis of a novel strategy to capture, recognize, and kill broad-spectrum types of CTCs from the peripheral blood.
“They Do Us Wrong”: Bringing Together Black Adolescent Girls’ Voices on School Staff’s Differential Treatment

During adolescence, Black girls face the developmental task of achieving a positive identity while developing skills to navigate hostile contexts, including schools. This study brings together quotes on student-staff interactions extracted during a qualitative meta-synthesis (n = 64 quotes) to discuss how Black adolescent girls interpreted being treated differently by staff. Black adolescent girls described differential treatment occurring because of one’s (a) race such as Black students being treated less humanely and punished more severely; (b) gender such as staff inadequately responding to sexual harassment; (c) intersection of race and gender such as staff inequitably applying the dress code; and (d) perception of the individual such as staff viewing one as a “bad” student. It appeared that differential treatment largely rooted in their perceived racialized/gendered identity negatively impacted Black girls and simultaneously provided little recourse for addressing differential treatment, likely undermining their sense of school belonging. This study brings together the voices of Black adolescent girls published across articles to focus specifically on the process of differential treatment within student-staff relationships.
Comparing Drivers of Spatial Variability in U.S. Lake and Stream Phosphorus Concentrations

Decision makers need to know the drivers of surface water phosphorus (P) concentrations, the environmental factors that mediate P loading in freshwater systems, and where pollution sources and mediating factors are co‐located to inform water quality restoration efforts. To provide this information, publicly available spatial data sets of P pollution sources and relevant environmental variables, like temperature, precipitation, and agricultural soil erodibility, were matched with >7,000 stream and lake total P observations throughout the conterminous United States. Using three statistical approaches, consisting of (a) correlation, (b) regression, and (c) machine learning techniques, we identified likely drivers of P concentrations. Surface water concentrations in streams were more strongly correlated and effectively predicted by annual fertilizer and manure input rates and agricultural legacy sources compared to that of lakes. This observation suggests that streams may be more immediately responsive to improvements in agricultural nutrient management. In contrast, lake concentrations, though still positively associated with agricultural input and surplus variables, may be more influenced by historic erosional inputs, internal lake recycling, and other environmental factors. Thus, lake TP concentrations may not be as immediately responsive as streams to improvements in phosphorus management. Both stream and lake P concentrations will potentially increase because of warming temperatures and forest recovering from past acidification, putting even further pressure on existing water quality restoration efforts to meet nutrient loading reduction targets. The identified spatial data sets and relationships elucidated in this effort can inform the placement and development of watershed restoration strategies to reduce excess P in aquatic systems.
Gypsogenin Battling for a Front Position in the Pentacyclic Triterpenes Game of Thrones on Anti-Cancer Therapy: A Critical Review—Dedicated to the Memory of Professor Hanaa M. Rady

In the last decade, gypsogenin has attracted widespread attention from medicinal chemists by virtue of its prominent anti-cancer potential. Despite its late identification, gypsogenin has proved itself as a new anti-proliferative player battling for a frontline position among other classic pentacyclic triterpenes such as oleanolic acid, glycyrrhetinic acid, ursolic acid, betulinic acid, and celastrol. Herein, we present the most important reactions of gypsogenin via modification of its four functional groups. Furthermore, we demonstrate insights into the anti-cancer activity of gypsogenin and its semisynthetic derivatives and go further by introducing our perspective to judiciously guide the prospective rational design. The present article opens a new venue for a better exploitation of gypsogenin chemical entity as a lead compound in cancer chemotherapy. To the best of our knowledge, this is the first review article exploring the anti-cancer activity of gypsogenin derivatives.
Update on Rapid-Eye-Movement Sleep Behavior Disorder (RBD): Focus on Its Strong Association with α-Synucleinopathies

REM sleep behavior disorder (RBD) is a parasomnia in which the customary generalized skeletal muscle atonia of REM sleep, “REM-atonia”, is compromised, allowing for the injurious acting-out of dreams. RBD can be idiopathic/isolated (iRBD) or symptomatic of neurological disorders, and can be triggered by most antidepressants. RBD mainly affects middle-aged and older adults, and is strongly linked with alpha-synucleinopathies, mainly Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). iRBD is now known to be the earliest and strongest predictor of future PD/DLB, which has stimulated a major international clinical and basic science research effort to enroll iRBD patients for upcoming neuroprotective/disease-modifying trials and to identify the most promising interventions to test in these cohorts. This review will provide the latest pertinent information on the rapidly expanding field of RBD. The methods included a PubMed literature search that included PubCrawlers, which utilizes the NCBI (National Center for Biotechnology Information) E-utils tools for publication retrieval, using the keywords “REM sleep behavior disorder” and “RBD”. The results yielded the latest updates on iRBD as prodromal PD/DLB, with the most promising biomarkers for phenoconversion provided, along with a presentation of three clinical research consortiums that are systematically gathering patients in preparation for enrollment in upcoming clinical trials: (i) The International RBD Study Group; (ii) The North American Prodromal Synucleinopathy (NAPS and NAPS2) Consortium; and (iii) The FARPRESTO Italian multicenter RBD research consortium. In addition, updates on the Parasomnia Overlap Disorder (RBD + NREM parasomnia) and on narcolepsy-RBD are provided, along with new epidemiologic data, the latest RBD management guidelines, and updates on animal models of RBD. Emerging areas of critical RBD research are also highlighted. In conclusion, RBD is a notable example of clinical and translational neuroscience research.
The Impact of a Child Life Video Preparation on Preoperative Anxiety and Post-Hospital Behaviors

Children undergoing surgery can experience significant preoperative anxiety and fear, which has been linked to regressive postoperative behaviors. Psychological preparation has been shown to reduce anxiety at time of anesthesia induction as well as negative behavioral changes after surgery. The current study seeks to provide insight into the impact of a video modeling intervention on preoperative anxiety and postoperative behavior changes. Participants included 60 patients ages 5 to 10 years undergoing same-day surgery. Patients were randomized into the video group (VG;n = 34) or no video group (NVG;n = 26). The Children’s Fear Scale (CFS) was administered to the patient and parent at the preoperative visit and again the day of surgery. The Post Hospitalization Behavior Questionnaire-Ambulatory Surgery (PHBQ-AS) was administered via telephone at postoperative days 2 and 14. This study found that an informational video designed by a child life specialist is an effective tool for reducing preoperative anxiety and postoperative behavior changes in children ages 5 to 10 years old undergoing ambulatory surgery. The video intervention benefitted patients when added to the provision of standard child life specialist services. Video modeling interventions, particularly when informed by the expertise of a child life specialist, are a useful modality for preoperative preparation of pediatric patients.
Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial

Pediatric obesity and cardiometabolic disease disproportionately impact minority communities. Sugar reduction is a promising prevention strategy with consistent cross-sectional associations of increased sugar consumption with unfavorable biomarkers of cardiometabolic disease. Few trials have tested the efficacy of pediatric sugar reduction interventions. Therefore, in a parallel-design trial, we randomized Latino youth with obesity (BMI ≥ 95th percentile) [n = 105; 14.8 years] to control (standard diet advice) or sugar reduction (clinical intervention with a goal of ≤10% of calories from free sugar) for 12-weeks. Outcomes included changes in glucose tolerance and its determinants as assessed by a 2-h frequently sample oral glucose tolerance test, fasting serum lipid profile (total cholesterol, HDL, LDL, triglycerides, cholesterol:HDL), and inflammatory markers (CRP, IL-6, TNF-α). Free sugar intake decreased in the intervention group compared to the control group [11.5% to 7.3% vs. 13.9% to 10.7% (% Energy), respectively, p = 0.02], but there were no effects on any outcome of interest (pall > 0.07). However, an exploratory analysis revealed that sugar reduction, independent of randomization, was associated with an improved Oral-disposition index (p < 0.001), triglycerides (p = 0.049), and TNF-α (p = 0.02). Dietary sugar reduction may have the potential to reduce chronic disease risks through improvements in beta-cell function, serum triglycerides, and inflammatory markers in Latino adolescents with obesity.
Learning variational models for blind image deconvolution

Along with noise, image blur is probably the most widespread reason for image degradation. It originates from a vast variety of sources, including atmospheric turbulences, defocus and motion. Nowadays fast and accurate deblurring algorithms become more and more important due to the ubiquitous smartphones. The majority of recent deblurring algorithms first estimate the point spread function, also known as blur kernel, and then perform a non-blind image deblurring. In this work we introduce a novel approach for both non-blind and blind image deblurring, which is motivated by variational models. We follow the idea of Chen et al. 2015 and derive a network structure which is related to minimizing an iteratively adapted energy functional. Moreover, we present a differentiable projection onto the unit simplex based on the Bregman divergence to constrain the blur kernels. The non-blind as well as blind deblurring networks are trained in a discriminative fashion to enhance properties of natural sharp images because recent discriminative reconstruction approaches demonstrated their superiority in terms of quality and runtime. Both deblurring networks are qualitatively evaluated and numerous experiments demonstrate the clear quality boost of the resulting image and blur kernel estimates. Furthermore, in contrast do neural networks, all individual parameters of the proposed networks can be easily interpreted due to the close relation to energy minimization.
Topological spin-hedgehog crystals of a chiral magnet as engineered with magnetic anisotropy

We report the engineering of spin-hedgehog crystals in thin films of the chiral magnet MnGe by tailoring the magnetic anisotropy. As evidenced by neutron scattering on films with different thicknesses and by varying a magnetic field, we can realize continuously deformable spin-hedgehog crystals, each of which is described as a superposition state of a different set of three spin spirals (a triple-q state). The directions of the three propagation vectors q vary systematically, gathering from the three orthogonal directions towards the film normal as the strength of the uniaxial magnetic anisotropy and/or the magnetic field applied along the film normal increase. The formation of triple-q states coincides with the onset of topological Hall signals, that are ascribed to skew scattering by an emergent magnetic field originating in the nontrivial topology of spin hedgehogs. These findings highlight how nanoengineering of chiral magnets makes possible the rational design of unique topological spin textures.
Diabetes Moderates the Link between Personality Traits and Self-Rated Health (SRH)

Objectives: The primary objective of this study is to explore the relationship between personality traits and self-rated health (SRH) in individuals with diabetes, while also comparing these associations with a group of healthy controls. Methods: The data for this study were obtained from the UK Household Longitudinal Study (UKHLS), comprising a sample of 1860 diabetes patients and 12,915 healthy controls who were matched in terms of age and sex. Hierarchical linear regression was utilized to analyze the data. The analysis included demographic variables such as age, sex, monthly income, highest educational qualification, marital status, and psychological distress assessed through the GHQ-12, personality traits, including Neuroticism, Agreeableness, Openness, Conscientiousness, and Extraversion, and diabetes status (0 for diabetes patients, 1 for healthy controls) as predictors. Interactions between personality traits and diabetes status were also included as predictors, with SRH serving as the dependent variable. Additionally, separate multiple regression analyses were conducted for diabetes patients and healthy controls, incorporating demographic variables, psychological distress, and personality traits as predictors, while SRH remained the dependent variable. Results: The findings of this study indicate that diabetes significantly moderates the association between Neuroticism and SRH. Specifically, both Neuroticism and Extraversion were negatively associated with SRH, whereas Openness and Conscientiousness exhibited a positive association with SRH in healthy controls. However, among diabetes patients, only Conscientiousness showed a positive association with SRH. Conclusion: Personality traits predict SRH in people with and without diabetes differently. Healthcare professionals and clinicians should try to come up with ways that improve SRH and thus better outcomes in diabetes patients based on the findings from the current study.
On the conformal killing p-form in compact Kaehlerian manifolds

Dans une variete de Kahler compacte a 2m dimensions (2m≥10)K 2m , une p-forme de Killing conforme (m≥p>3) est parallele. Dans une variete de Kahler compacte a 2m dimensions (2m≥6¬=10)K 2m , une 3-forme de Killing conforme est parallele
A High-Performance UVA Photodetector Based on Polycrystalline Perovskite MAPbCl3/TiO2 Nanorods Heterojunctions

The application of TiO2 nanorods in the field of ultraviolet (UV) photodetectors is hindered by a high dark current, which is attributed to crystal surface defects and intrinsic excitation by carrier thermal diffusion. Here, a photodetector based on polycrystalline perovskite MAPbCl3/TiO2 nanorods heterojunctions has been fabricated to overcome the shortcoming. The structure was composed of horizontal MAPbCl3 polycrystalline and vertically aligned TiO2 nanorods array. Many localized depletion regions at the MAPbCl3/TiO2 interface can reduce the dark current. The TiO2/MAPbCl3 detector shows high performance including a high ratio of light-dark current of about six orders of magnitude, which is much larger than that of the TiO2 detector. This study indicates the potential in the TiO2/MAPbCl3 heterojunction to fabricate high-performance UV detectors.
Biological Activities of Ceratonia siliqua Pod and Seed Extracts: A Comparative Analysis of Two Cretan Cultivars

Ceratonia siliqua L. , commonly known as the carob tree, appears in most Mediterranean countries, often cultivated for the collection of its fruits to be used as food for humans and animals. This study was aimed at the phytochemical characterization of two common Cretan C. siliqua cultivars and the biological evaluation of deseeded pod and seed extracts regarding their putative use in cosmetics. Gas and liquid chromatographic techniques were used to assess their essential oil, fatty acid, and carbohydrate profiles. Cell-free assays, including free-radical scavenging; the inhibition of tyrosinase and collagenase; the blocking of advanced glycation end product (AGE) formation; along with assays in human skin fibroblast cultures, i.e., reactive oxygen species suppression, glutathione stimulation, and protection from oxidative stress and from ultraviolet (UVB) radiation, were also used. Extracts from both cultivars were found to possess antioxidant capacity, tyrosinase- and collagenase-inhibitory activities, an ability to block glucose-induced AGEs, and in certain cases, UVB absorbance and photoprotective activities. Seed extracts were in general more active, while the use of 30% aqueous methanol seemed to be more efficient than n-hexane for extraction. Serial partition of the most active extracts resulted in fractions with enriched biological activities. These properties make Cretan carob extracts and their fractions suitable candidates for use in cosmetics.
A mulberry 9-cis-epoxycarotenoid dioxygenase gene MaNCED1 is involved in plant growth regulation and confers salt and drought tolerance in transgenic tobacco

The phytohormone abscisic acid (ABA) is vital in regulating root elongation, seed germination, and abiotic stress responses in plants. Conversely, the mechanisms of ABA in mulberry root growth, seed germination, and abiotic stress responses are poorly understood. Here, we reported that exogenous ABA and drought treatment inhibited the growth of mulberry seedlings but significantly increased the ratio of root/stem. Inhibition of ABA synthesis by fluridone and sodium tungstate resulted in the decrease of root/stem ratio. We also showed that the expression of MaNCED1 in the root was strongly induced by drought and salt stress. Increasing the expression of MaNCED1 in tobacco using overexpression leads to increased root elongation and reduced seed germination. Compared with the wild type, the accumulation of H2O2 and MDA was reduced, while the POD activity and proline content was increased in the transgenic plants after drought and salt treatment. Further studies revealed increased resistance to drought and salt stress in MaNCED1 overexpressed tobaccos. Meanwhile, the auxin and ethylene signal pathway-related gene expression levels increased in MaNCED1 overexpressed tobaccos. This study demonstrated the roles of mulberry MaNCED1 in regulating plant development and abiotic stress responses. It gave further insights into the coordinated regulation of ABA, auxin, and ethylene in seed growth and germination.