Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparative Study on Methods for Fusing Data-Driven and Physics-Based Models for Hybrid Remaining Useful Life Prediction of Air Filters

Approaches for diagnosis and prognosis of the health of engineering systems are divided into data-driven, model-based, and hybrid methods. Data-driven methods depend on the availability of data. Model-based methods require knowledge of the degradation process. A great effort of data generation along with the high complexity of degradation processes often limits both approaches. To mitigate these limitations, the combination of data and knowledge through hybrid methods is examined in this paper. This approach is compared to the alternative approach of reducing the effort of generating training data, as both are gaining importance in diagnostics and prognostics. A new categorization of hybrid prognostic methods for combining data-driven and physics-based models is presented, along with references to existing realizations of these methods. Based on the categorization, a case study on the hybrid remaining useful life prediction of a filtration process is conducted. Several hybrid methods are implemented and tested in this study. Through the combination of models, an improvement in predictive accuracy is achieved. In addition, the paper examines systematic attributes of the individual hybrid methods. Statements on the influence of data scarcity on the predictive accuracy, data-driven models with high variance, and the computational efficiency of the hybrid methods are made. It is shown that these statements are supported by the case study’s results.
Rectal Cancer after Prostate Radiation: A Complex and Controversial Disease

Simple Summary Radiation therapy is commonly used in the treatment of prostate cancer, but it is a carcinogen itself. Long-term survivors of prostate cancer who were treated with pelvic radiotherapy have been reported to be at increased risk for developing rectal cancer compared to those treated with surgery. The treatment of radiation-associated rectal cancer is challenging, and the evidence behind this disease is limited and often contradictory. Here, we review the available literature and discuss the unique considerations of treating patients with rectal cancer after prostate radiotherapy. Abstract A small proportion of rectal adenocarcinomas develop in patients many years after the treatment of a previous cancer using pelvic radiation, and the incidence of these rectal cancers depends on the length of follow-up from the end of radiotherapy. The risk of radiation-associated rectal cancer (RARC) is higher in patients treated with prostate external beam radiotherapy than it is in patients treated with brachytherapy. The molecular features of RARC have not been fully investigated, and survival is lower compared to non-irradiated rectal cancer patients. Ultimately, it is unclear whether the worse outcomes are related to differences in patient characteristics, treatment-related factors, or tumor biology. Radiation is widely used in the management of rectal adenocarcinoma; however, pelvic re-irradiation of RARC is challenging and carries a higher risk of treatment complications. Although RARC can develop in patients treated for a variety of malignancies, it is most common in patients treated for prostate cancer. This study will review the incidence, molecular characteristics, clinical course, and treatment outcomes of rectal adenocarcinoma in patients previously treated with radiation for prostate cancer. For clarity, we will distinguish between rectal cancer not associated with prostate cancer (RCNAPC), rectal cancer in non-irradiated prostate cancer patients (RCNRPC), and rectal cancer in irradiated prostate cancer patients (RCRPC). RARC represents a unique but understudied subset of rectal cancer, and thus requires a more comprehensive investigation in order to improve its treatment and prognosis.
Spatial analysis of multi-environment early generation variety trials

A fully efficient approach for the analysis of multi-environment early stage variety trials is considered that accommodates a general spatial covariance structure for the errors of each trial. The analysis simultaneously produces best linear unbiased predictors of the genotype and genotype by environment interaction effects and residual maximum likelihood estimates of the spatial parameters and variance components. Two motivating examples are presented and analyzed, and the results suggest that the previous approximate analyses can seriously affect estimation of the genetic merit of breeding lines, particularly for models with more complex variance structures.
How Can We Prevent Mother-to-Child Transmission of HTLV-1?

The perception of human T-cell leukemia virus type 1 (HTlV-1) infection as a “silent disease” has recently given way to concern that its presence may be having a variety of effects. HTLV-1 is known to cause adult T-cell leukemia (ATL), an aggressive cancer of peripheral CD4 T cells; however, it is also responsible for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Most patients develop ATL as a result of HTLV-1 mother-to-child transmission. The primary route of mother-to-child transmission is through the mother’s milk. In the absence of effective drug therapy, total artificial nutrition such as exclusive formula feeding is a reliable means of preventing mother-to-child transmission after birth, except for a small percentage of prenatal infections. A recent study found that the rate of mother-to-child transmission with short-term breastfeeding (within 90 days) did not exceed that of total artificial nutrition. Because these preventive measures are in exchange for the benefits of breastfeeding, clinical applications of antiretroviral drugs and immunotherapy with vaccines and neutralizing antibodies are urgently needed.
Numerical model of capacitance in vertical-cavity surface-emitting lasers

In this paper we present a model of impedance and modulation time constants for vertical-cavity surface-emitting lasers (VCSELs) operating above threshold current. A 3D numerical model of potential distribution in the device under a constant bias is used to determine resistances and capacitances of an appropriate equivalent circuit. The model has been verified by comparing the theoretical and measured impedance as a function of frequency Z(f). The measured Z(f) is determined from S11 small signal modulation experiments. The comparison has been performed for frequencies up to 40 GHz and a wide range of above threshold currents, for two oxide-confined VCSELs of different aperture diameters. We obtained a very good quantitative agreement for frequencies up to about 15 GHz and qualitative agreement over the entire range of currents and frequencies.
Comparison of the vertical jump performance of footballers with cerebral palsy at different competitive levels

: Vertical jump (VJ) capacity is a common assessment for monitoring athletes' neuromuscular function and has been proposed as a differentiating indicator between competitive levels of football players. This study aimed to compare the VJ capacity of Chilean footballers with cerebral palsy (CP) with international and national levels of proficiency, also according to their sport classes (i.e., FT1 ‒ FT3). A total sample of 41 male footballers with CP were divided into international-level (n = 18) and national-level (n = 23) groups. All the participants performed two maximal squat jumps (SJs) and countermovement jumps (CMJs), where the best height obtained was registered. The VJ performance was significantly different between competitive levels, and players at international level had better scores ( p < .001) than the national level in SJ ( d g = 1.83, large) and CMJ ( d g = 2.08, large). Considering the sport classes, significant differences were found in SJ ( p = .024) and CMJ ( p = .035), in which FT3 players performed higher jumping heights than FT1 players ( d g = -.84 to -1.01, large). These results provide a deeper understanding of the differences in the motor impairment-specific performance of para-footballers with CP, where coaches and strength-conditioning professionals should consider VJ assessment for monitoring training and as a component for talent detection in this para-sport.
The Oral Health of a Group of 19th Century South Australian Settlers in Relation to Their General Health and Compared with That of Contemporaneous Samples

The aims of this study are to determine the oral health status of a rare sample of 19th-century migrant settlers to South Australia, how oral conditions may have influenced their general health, and how the oral health of this group compares with contemporaneous samples in Australia, New Zealand, and Britain. Dentitions of 18 adults and 22 subadults were investigated using non-destructive methods (micro-CT, macroscopic, radiographic). Extensive carious lesions were identified in seventeen adults and four subadults, and from this group one subadult and sixteen adults had antemortem tooth loss. Sixteen adults showed evidence of periodontal disease. Enamel hypoplastic (EH) defects were identified in fourteen adults and nine subadults. Many individuals with dental defects also had skeletal signs of comorbidities. South Australian individuals had the same percentage of carious lesions as the British sample (53%), more than other historic Australian samples, but less than a contemporary New Zealand sample. Over 50% of individuals from all the historic cemeteries had EH defects, suggesting systemic health insults during dental development were common during the 19th century. The overall oral health of the South Australian settlers was poor but, in some categories, (tooth wear, periapical abscess, periodontal disease), better than the other historic samples.
Double-Stage Rate Bumpless Transfer Control for Switched Systems With Severely Unstable Dynamics

This brief investigates the double-stage rate bumpless transfer (DSRBT) control for switched linear systems possing severely unstable dynamics (SUDs). The considered SUDs mean all destabilizing subsystems and partially destabilizing switching instants. A new DSRBT performance is defined, which implies the transient control purpose can be achieved under asynchronous switching. Then, an improved dwell time method that restricts the ratio of the total number of stabilizing and destabilizing switching instants is proposed, in which the ratio is designed without incorporating additional parameters. By co-designing a switching signal and a series of dynamic output feedback controllers, a sufficient condition is given to ensure both the exponential stabilization and the DSRBT performance. Finally, a numerical example and an application of the tunnel diode circuit are given to demonstrate the effectiveness of the proposed method.
Cellulitis in Hajj Pilgrims: Role of Environmental Temperature and Population Size of Pilgrims as a Contributory Factor

Background Cellulitis is a common infection of the skin and subcutaneous tissue. Meteorological and environmental temperatures were previously identified as potential risk factors for causation and the patient’s odds of hospitalization. In this regard, we aim to study the pattern of cellulitis during 10 Hajj seasons and examine the impact of changing seasonal temperatures and overall pilgrim populations as potential risk factors. Methodology In-hospital cellulitis was studied within the context of the Hajj. A retrospective review of pilgrim patients coded for cellulitis was undertaken for the Hajj seasons between 2004 and 2012. Possible roles of environmental temperatures, pilgrim population sizes, and ethnicity were examined as potential risk factors. Results A total of 381 patients belonging to 42 nationalities were identified, with 285 (75%) males and 96 (25%) females with a mean age of 63 years. On average, cellulitis accounted for 23.5% of general surgical admissions with proportional increases from 2004 to 2012 (r= 0.73, p= 0.016), which significantly correlated with the rise in seasonal temperatures (r = 0.7, p= 0.023). Conclusions The findings of this study identified cellulitis as a significant health risk during the Hajj, which is likely to be prevalent in warmer seasons. Our results may assist clinicians in educating Hajj pilgrims of different nationalities about the increased risk of cellulitis during warm seasons and possible predisposing environmental factors of infection.
Casein Hydrolysate Alleviates Adipose Chronic Inflammation in High Fat-Diet Induced Obese C57BL/6J Mice through MAPK Pathway

Obesity-induced adipose chronic inflammation is closely related to the development of insulin resistance and T2DM. Tripeptides l-valyl-l-prolyl-l-proline (VPP) and l-isoleucyl-l-prolyl-L-proline (IPP) derived from bovine casein have been reported to prevent inflammatory changes and mitigate insulin resistance in adipocytes. In this study, we aimed to investigate the influence of casein hydrolysates (CH) containing VPP and IPP on a high fat diet (HFD)-induced obese mice and cytokine TNF-α-induced adipocytes. Our data showed that CH alleviated chronic inflammation both in vivo and in vitro. 4% CH suppressed HFD-induced systemic inflammatory factors, hypertrophic white adipocytes, and macrophage infiltration. More importantly, CH was able to improve adipocyte dysfunction induced by TNF-α by increasing the expression of CCAAT/enhancer binding protein α (C/EBP-α) rather than peroxisome proliferator-activated receptor γ (PPAR-γ). Furthermore, CH also dose-dependently suppressed mitogen-activated protein kinase (MAPK)-c-Jun N-terminal kinase (JNK) phosphorylation and enhanced the phosphorylation of Erk 1/2, but not nuclear factor-kappa B (NF-κB) p65 phosphorylation, in TNF-α-induced 3T3-L1 cells. These results indicated that CH could ameliorate adipose chronic inflammation through the MAPK pathway. Altogether, our findings suggested that 4% CH supplementation for 6 weeks exerted a protective role in preventing obesity-related inflammation and adipose dysfunction.
Beyond Moral Reasoning Scores: Life Story Interviews and the Interpersonal Nature of Advertising

Abstract The current study is the first to report N2 Defining Issues Test (DIT) moral reasoning scores and life-story interviews of advertising executives perceived as ethical leaders. Combining N2 scores with in-depth moral justifications provides a detailed view of morality to better understand what normatively appropriate behavior is, both in and outside of advertising, and how it develops. Scores reflect the preference to apply universal moral principles, especially when depicting strategic communication scenarios, yet there is less preference for universal moral reasoning when personal interest justifications are also considered. Life stories provide evidence of introspection and growth in response to adversity and ethical breaches; situational moral reasoning reflective of the human-centric, empathetic, and interpersonal nature of advertising; and a desire to do social good representative of empathy in action.
Fundamental Parameters and Elemental Abundances of 160 F-G-K Stars Based on OAO Spectrum Database

The properties of 160 F, G, and K disk dwarfs/subgiants (including 27 planet-host stars) mostly within � 0:6 . [Fe/H] . +0:4 ,t he Okayama Astrophysical Observatory spectrum collection of which had been made open to the public recently, were extensively investigated with particular attention to determining (1) the mass and the age with the help of theoretical stellar evolution calculations, (2) the kinematic parameters of orbital motions in the Galaxy, and (3) the abundances of 15 elements (Na, Mg, Al, Si, S, Ca, Sc, Ti, V, Cr, Mn, Co, Ni, Cu, and Zn) by analyzing the spectra in this database. The resulting characteristics are discussed in terms of several relevant topics of interest, such as a validity check for assuming LTE, the [X/Fe] vs. [Fe/H] diagram containing information on the chemical evolution of the Galactic disk, the age–metallicity–kinematics relation, and the difference/similarity between stars with an dw ithout planets.
Self-Help, Natality and ‘Civic Growth’

Abstract This paper examines the role that SHGs (self-help groups) have played in the creation of ‘civic growth’ and changing electoral politics in India. Based on ethnographic engagement in a village in West Bengal before and after the formation of these groups, the impact of the transformative effect of these groups on women is placed in a wider political context. The activity of the SHG enabled horizontal solidarities to emerge despite the vertical divisions in village society and successfully challenge the status quo. It builds on a growing literature on women’s empowerment and capacity for collective action through SHGs to show that the notion of ‘empowerment’ can be extended to include the capability for active citizenship and skills in how to do politics, what Arendt calls ‘natality’.
Design and Analysis of Multibit Multiply and Accumulate (MAC) unit: An Analog In-Memory Computing Approach

In-memory computing for multiplication operations is an approach towards mitigating the overhead caused by the migration of data between the memory and the processor observed in traditional architectures. 6T SRAMs (Static Random Access Memory) are an excellent choice for implementing this idea due to their interoperability with numerous cutting-edge processors and their compact design. In this paper, we discuss a novel method that performs in-memory dot product operations without affecting the regular processes and circuitry of the memory unit. By using current mirror (CM) circuits, the dot-product multiplication of the bits was obtained and the linearity was scrutinized and improved upon. The performance of the circuit was further examined and compared to existing designs for in-memory computation (IMC). The proposed work has an average delay of 17.07 ps and an appreciable power-delay product (PDP) of 0.01289 fJ.
Optimal Allocation of Photovoltaic (PV) System Considering Weather Conditions using Evolutionary Programming (EP) for Enhanced Power System Resiliency

This project introduces an optimal PV system allocation by considering weather conditions through a system reliability assessment. The Markov model is performed with embedded data of the PV generator and weather conditions to obtain a forced outage rate (FOR) and both (FOR) will be merged together to get a new FOR. Then, a load of a 24 Reliability Test System and a variant number of populations composed of PV system size is used to obtain the expected unserved energy (EUE) and loss of load expectation (LOLE). The EP technique for optimization is applied to determine the best sizing and generating unit (GU) of the PV system with the EUE close to zero and LOLE less than 2.4 hours per year. This paper used the effect of weather conditions on the PV system as a case analysis.
A Review on the Adsorption of Phenol Derivatives from Wastewater

Several environmental companies consider phenols compounds to be very dangerous pollutants because they are highly toxic and non-biodegradable, notably their high toxicity in water. For this reason, several processes have been studied by researchers to understand the mechanisms of elimination of phenolic compounds. Adsorption remains the best technique due to its characteristics, in fact, it is non-destructive and simple to use as well as have more other advantages, such as practicality and efficiency and low cost, Therefore, these methods need to be wi - dely developed on an industrial scale to remove phenol derivatives and achieve wastewater quality in accordance with standards. On the other hand, the development of these adsorption methods is highly dependent on new re - search on materials from abundant natural resources, namely apatites or biomaterials.
A fixed point theorem of Banach--Caccioppoli type on a class of generalized metric spaces

We give a fixed point theorem related to the contraction mapping principle of Banach and Caccioppoli; here we have considered generalized metric spaces, that is metric spaces with the triangular inequality replaced by similar ones which involve four or more points instead of three. At the end of the paper an example is provided to show the improvement of our result with respect to the classical one.
ZnO Nanorods Create a Hypoxic State with Induction of HIF-1 and EPAS1, Autophagy, and Mitophagy in Cancer and Non-Cancer Cells

Nanomaterials are gaining increasing attention as innovative materials in medicine. Among nanomaterials, zinc oxide (ZnO) nanostructures are particularly appealing because of their opto-electrical, antimicrobial, and photochemical properties. Although ZnO is recognized as a safe material and the Zn ion (Zn2+) concentration is strictly regulated at a cellular and systemic level, different studies have demonstrated cellular toxicity of ZnO nanoparticles (ZnO-NPs) and ZnO nanorods (ZnO-NRs). Recently, ZnO-NP toxicity has been shown to depend on the intracellular accumulation of ROS, activation of autophagy and mitophagy, as well as stabilization and accumulation of hypoxia-inducible factor-1α (HIF-1α) protein. However, if the same pathway is also activated by ZnO-NRs and how non-cancer cells respond to ZnO-NR treatment, are still unknown. To answer to these questions, we treated epithelial HaCaT and breast cancer MCF-7 cells with different ZnO-NR concentrations. Our results showed that ZnO-NR treatments increased cell death through ROS accumulation, HIF-1α and endothelial PAS domain protein 1 (EPAS1) activation, and induction of autophagy and mitophagy in both cell lines. These results, while on one side, confirmed that ZnO-NRs can be used to reduce cancer growth, on the other side, raised some concerns on the activation of a hypoxic response in normal cells that, in the long run, could induce cellular transformation.
Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review

Hard dental tissues possess a complex hierarchical structure that is particularly evident in enamel, the most mineralised substance in the human body. Its complex and interlinked organisation at the Ångstrom (crystal lattice), nano-, micro-, and macro-scales is the result of evolutionary optimisation for mechanical and functional performance: hardness and stiffness, fracture toughness, thermal, and chemical resistance. Understanding the physical–chemical–structural relationships at each scale requires the application of appropriately sensitive and resolving probes. Synchrotron X-ray techniques offer the possibility to progress significantly beyond the capabilities of conventional laboratory instruments, i.e., X-ray diffractometers, and electron and atomic force microscopes. The last few decades have witnessed the accumulation of results obtained from X-ray scattering (diffraction), spectroscopy (including polarisation analysis), and imaging (including ptychography and tomography). The current article presents a multi-disciplinary review of nearly 40 years of discoveries and advancements, primarily pertaining to the study of enamel and its demineralisation (caries), but also linked to the investigations of other mineralised tissues such as dentine, bone, etc. The modelling approaches informed by these observations are also overviewed. The strategic aim of the present review was to identify and evaluate prospective avenues for analysing dental tissues and developing treatments and prophylaxis for improved dental health.