Miracle-dz/UniFAR-FTUs huggingface dataset:
Determining the phosphorus release curve for Sunphase HT phytase in nursery pig diets

Abstract A total of 280 pigs (DNA 241 × 600, initially 10.4 ± 0.24 kg) were used in a 21-d study to determine the available P (aP) release curve for Sunphase HT phytase (Wuhan Sunhy Biology Co., Ltd., Wuhan, P.R. China) when fed diets with a high phytate concentration. On day 21 post-weaning, considered day 0 of the study, pigs were blocked by average pen body weight (BW) and randomly allotted to 1 of 7 dietary treatments with 5 pigs per pen and 8 pens per treatment. Dietary treatments were derived from a single basal diet, and ingredients including phytase, monocalcium P, limestone, and sand were added to create the treatment diets. Treatments included three diets with increasing (0.11%, 0.19%, and 0.27%) aP from monocalcium P, or four diets with increasing phytase (250, 500, 1,000, or 2,000 phytase unit (FTU)/kg) added to the diet formulated to 0.11% aP. All diets were corn–soybean meal–canola meal-based and were formulated to contain 1.24% SID Lys, a 1.10:1 total calcium-to-phosphorus ratio, and a calculated 0.32% phytate P. Prior to the beginning of the study, all pigs were fed a diet containing 0.11% aP from days 18 to 21 post-weaning. At the conclusion of the study, 1 pig, closest to the mean weight of each pen, was euthanized, and the right fibula, 10th rib, and metacarpal were collected to determine bone ash and density. After cleaning, bones were submerged in ultra-purified water under a vacuum for 4 h and then weighed to calculate the density (Archimedes principle). For bone ash, bones were processed using the non-defatted method. From days 0 to 21, increasing aP from monocalcium P increased (linear, P ≤ 0.014) average daily gain (ADG), gain-to-feed (G:F), and final BW. Pigs fed increasing phytase had increased (linear, P ≤ 0.045) ADG, final BW, and plasma inositol concentration as well as improved (quadratic, P = 0.023) G:F. For bone characteristics, pigs fed increasing aP from inorganic P had a linear improvement (P ≤ 0.019) in fibula bone ash weight and percentage bone ash, rib bone ash weight and bone density, and all metacarpal bone properties, with a quadratic response (P ≤ 0.030) for fibula bone density and rib percentage ash. Additionally, pigs fed increasing phytase had increased (P < 0.05) bone ash weight, percentage bone ash, and bone density in either a linear or quadratic fashion depending on the bone analyzed. The available P release curve generated for Sunphase HT phytase for percentage bone ash combining values from the right fibula, 10th rib, and metacarpal is aP release, % = (0.360 × FTU) ÷ (2,330.250 + FTU).
Strategies to overcome low MHC-I expression in paediatric and adult tumours

Summary Immunotherapy has made significant advancements in cancer treatments, improving patients’ survival rates and quality of life. Several challenges still need to be addressed, which include the considerable fraction of incomplete curative responses in cancer patients, the development of therapy resistance by tumours, and the occurrence of adverse effects, such as inflammatory and autoimmune complications. Paediatric tumours usually exhibit lower responsiveness to immunotherapies compared to adult tumours. Although the underlying reasons are not yet fully understood, one known mechanism by which tumours avoid immune recognition is through reduced cell surface expression of major histocompatibility complex class I (MHC-I) complexes. Accordingly, the reduced presentation of neoantigens by MHC-I hinders the recognition and targeting of tumour cells by CD8+ T cells, impeding T-cell-mediated cytotoxic anti-tumour responses. MHC-I downregulation indeed often correlates with a poorer prognosis and diminished response to immunotherapy. Understanding the mechanisms underlying MHC-I downregulation in different types of paediatric and adult tumours is crucial for developing strategies to restore MHC-I expression and enhance anti-tumour immune responses. We here discuss progress in MHC-I-based immunotherapies against cancers.
Determinants of diabetic nephropathy among adult diabetic patients on follow-up at public hospitals in Addis Ababa, Ethiopia: A case-control study

Background: Diabetic nephropathy is defined as patients with diabetes mellitus who have persistent proteinuria for at least three consecutive measurements per year, a high blood creatinine level (>130 mol/l), or a decrease in glomerular filtration rate (<60 ml/min). Limited studies were done in Ethiopia on determinants of diabetic nephropathy among diabetic patients. Therefore, this study aimed to identify determinants of nephropathy among adult diabetic patients on follow-up at public hospitals in Addis Ababa, Ethiopia, 2022. Methods: A hospital-based unmatched case-control study design was conducted from 6 September to 9 November 2022, among diabetic patients on follow-up at public health hospitals in Addis Ababa. Using consecutive sampling techniques, a total of 442 (353 controls and 89 cases) were recruited, with a control-to-case ratio of 4:1. The data were collected using a structured and interview-administered questionnaire and variables like high-density lipoprotein, low-density lipoprotein, Glycated hemoglobin, and type of diabetes were extracted from the medical records of the patients using a checklist. The collected data were entered into Epidata 3.1 and analyzed by STATA version 15.0. Variables with a p-value < 0.25 in the bivariable logistic regression were selected for the final model. In multivariable logistic regression model fitting, variables with a p-value < 0.05 with 95% CI adjusted odds ratio have declared statistically significant risk factors of diabetic nephropathy. Results: In this study, out of 442 study participants, 334 controls and 89 cases were included in the analysis, with a response rate of 94.6% and 100%, respectively. The majority of the study participants were 92.13% of cases and 84.13% of controls; 7.87% of cases, and 15.87% of controls were type 2 diabetes mellitus. Age 65 and above years old (AOR: 2.42; 95% CI: 1.28, 4.57); Smoking cigarette (AOR: 2.22; 95% CI: 1.18, 4.16); Non-adherent to diet (AOR: 2.11; 95% CI: 1.15, 3.84); Drinking alcohols (AOR: 1.95; 95% CI: 1.07, 3.52); Duration with diabetes more than 10 years (AOR: 3.39; 95% CI: 1.76, 6.54); Poor glycemic control (AOR: 2.19; 95% CI: 1.23, 4.28); and Low-density lipoprotein (AOR: 2.97; 95% CI: 1.69, 5.28) were found to be statistically significant risk factors of nephropathy among diabetic patients. Conclusion: This study found that old age, smoking cigarettes, non-adherence to diet, duration of diabetes, alcohol drinking, Glycated hemoglobin A1C, and high low-density lipoprotein were risk factors for nephropathy. Hence, continuous health education on lifestyle modifications and diabetic-related complications in each follow-up visit via front-line health professionals are very essential to avert the problem.
Successful Treatment of Eosinophilic Granulomatosis With Polyangiitis: A Case of Refractory Peripheral Neuropathy and Comorbid Chronic Progressive Pulmonary Aspergillosis Treated With Mepolizumab

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic necrotizing vasculitis accompanied by granulomas and eosinophilic inflammation, exhibiting marked peripheral blood eosinophiliaandasthma. Neuropathy is a difficult-to-treat common manifestation that frequently remains after achieving clinical remission with current therapy in a subpopulation of patients with EGPA with or without life-threatening organ involvement. Refractory neuropathy regularly reduces the quality of life and requires glucocorticoids (GCs) and/or immunosuppressants for a long time. Long-term immunosuppressive therapy is a factor associated with a high risk of adverse effects. Mepolizumab, at three times the dose for severe asthma, provides benefits to induce the remission of relapsing or refractory EGPA and to reduce the doses of GC. Here, we present a case of EGPA successfully treated with mepolizumab at the reference dose for severe asthma. In this case, mepolizumab resolved peripheral neuropathy resistant to corticosteroids, immunosuppressants, and intravenous immunoglobulin and contributed to the improvement of comorbid chronic pulmonary aspergillosis during GC dose reduction.
Social Media Use and Daily Well-Being: The Role of Quantity and Quality of Social Support.

There have been mixed findings on whether social media use is positively or negatively related to well-being. Using the Midlife in the United States Refresher study (N = 782, age 25-75), multilevel structural equation modeling examined social support quantity (time giving and receiving) and quality of as mediators at both the within- (intraindividual) and between-person (interindividual) levels. Giving support significantly mediated at within- and between-person levels: more social media use was associated with more time giving support and worse well-being. Receiving support significantly mediated at the between-person level: more social media use was associated with more time receiving support and worse well-being. When examining social support quality as a mediator, findings showed that more social media use to contact family/friends was related to better social support quality and better well-being. Results added to our understanding of the relationship between social media use and well-being by considering the role of social support quantity/quality.
Contribution to the magnetostratigraphy of the Carnian : New magneto-biostratigraphic constraints from Pignola-2 and Dibona marine sections, Italy

In an effort to improve the calibration of the Late Triassic time scale, two stratigraphic successions in Italy were investigated for magnetostratigraphy: the Pignola-2 (Southern Apennines) and the Dibona (Dolomites) sections. These sections reveal a sequence of biostratigraphically calibrated (conodonts and palynomorphs) magnetic polarity zones encompassing the Julian/Tuvalian boundary (Carnian). A total of 63 samples have been collected from the Pignola-2 section that helped defining 3 magnetozones. These data are constrained by a published radiometric U/Pb age of 230.91 0.33 Ma from the Aglianico ash-bed (Furin et al. 2006). From the Dibona section, 81 samples have been collected, revealing 2 magnetozones in the Heiligkreuz Fm. (lower part of the succession) and 2 magnetozones in the Travenanzes Fm. (upper part). The Dibona section provided only few high-quality paleomagnetic data in spite of the sampling effort, so we considered only the Pignola-2 section as suitable for the correlation with other Carnian sections from the literature, in order to define the magnetostratigraphy around the Julian/Tuvalian boundary in the Tethys realm. The correlation between the Pignola-2 and the Newark Astrochronological Polarity Time Scale (APTS) provides independent insights on the age of the base of the Newark basin APTS. We found that the U-Pb zircon-dated Pignola-2 level, magnetostratigraphically projected on the Newark APTS, falls within Chrons E5–E4 at around 231 Ma, in agreement with the (extrapolated) astrochronological ages of the Newark APTS.
Risk and protective factors associated with gang involved youth in a Caribbean nation: Analysis of the Trinidad and Tobago Youth Survey

Objectives: The present study sought to examine the prevalence of gang involvement, the risk and protective factors associated with gang involvement, and the association between gang involvement and exposure to multiple risk and protective factors among school aged youth in Trinidad and Tobago. Methods: The survey instrument used in the present study measured 30 risk factors and 13 protective factors within four domains: community, school, family, and peer/individual. The instrument also measured levels of alcohol, drug use, and delinquency. The final sample included 2 206 students enrolled in 22 urban public schools. Results: About 7.7% of youth reported being a gang associate, 6.8% reported being a former gang member, and 6.2% reported being a current gang member. Gang involvement was associated with perceived availability of handguns, neighborhood mobility, having parents who favored anti-social behavior, early initiation of antisocial behavior, intention to use drugs, having antisocial peers, and having peers who use drugs. Those with social skills, belief in moral order, and those who had interaction with pro-social peers were significantly less likely to self-report gang membership. Additionally, the probability of gang involvement increased as the number of risk factors increased. Conclusions: Gang membership among public school youth is about as prevalent in Trinidad as it is in the United States, Canada, and Western Europe, but further research is needed. Although risk factors associated with gang involvement were present in all four domains, peer-individual risk factors were disproportionately likely to be associated with gang status. The most effective gang prevention strategies might be those that focus on multiple risk factors, with an emphasis toward peer-individual factors.
Influence of NPK Blended Fertilizer Application on Chlorophyll Content and Tissue Mineral Contents of Two Finger Millet Varieties Grown in Acid Soils of Kakamega, Western Kenya

Acidic soils with high exchangeable aluminium ions occur in most parts of Kenya, western Kenya inclusive. Aluminium toxicity is a serious environmental problem that affects crop productivity in Western Kenya region. The county governments of Kakamega, Bungoma, Vihiga, Busia and Trans-Nzoia are promoting the application of NPK blended fertilizer to ameliorate the soil acidity to increase maize production. Finger millet (Eleusine coracana L) is one of the important cereal crops in Kenya and has the ability to grow under unfavorable environmental conditions much better than other cereal crops. It is for this reason that it is currently being popularized in efforts to address food security in the region, however, the effects of NPK blended fertilizer application on the selected physiological parameters of the crop is little known, hence prompting the study. The objective of this study was to investigate the effect of NPK blended fertilizer application on chlorophyll content index and plant tissue mineral analysis. Randomized Complete Block Design with 0,25,50,75,100 kg application rates per acre of NPK blended fertilizer as the treatments were applied in two equal split applications. The measured parameters were chlorophyll content index using CCM-200 spectrophotometer, (Opti- Sciences Inc., Hudson, USA) from the plant leaves at 50% plot maturity. Motsara and Roy Procedures were used to determine plant tissue analysis for nitrogen, phosphorus, potassium, calcium, and magnesium at physiological maturity from the leaves. Data were subjected to analysis of variance (ANOVA) using GenStat statistical package version 15.1. Means were separated by Least Significant Difference (LSD) test at 0.05 probability level. Regression analysis was used to estimate the relationship between variables. At the 75 kg/acre rate, the leaves showed the significant P<0.05 chlorophyll content, calcium, and potassium in both varieties for the two seasons, short rain, and long rain respectively. Control had the lowest physiological activities for both seasons regarding chlorophyll content, tissue calcium, magnesium, nitrogen, phosphorus, and potassium. Significant nitrogen content was observed on Gulu-E variety for both seasons on the highest rate whereas the same trend was observed on P-224 variety and during the short rainy season, a linear increase was observed with increasing NPK blended fertilizer rates. No conclusive pattern was observed during the short rainy season but with the control exhibiting the lowest phosphorus content for both varieties. A significant response to physiology (chlorophyll and plant leaf tissue mineral) might have been due to increased uptake of mineral nutrients present in the NPK blended fertilizer and increased soil pH caused by the liming action of the NPK blended fertilizer.
A Review of the cause of rangeland degradation on Qinghai-Tibet Plateau

The principal factors causing Qinghai-Tibet Plateau grassland degradation includes climate,wild life and human activities.Temperature and precipitation are the main elements within climatic.Short term climatic change is not the main factor inducing grassland degradation.From long run,interaction between climate change and grassland degradation can induce the deterioration of grassland ecological system.Small mammals are the principal element affecting grassland,and their damage mainly depend on the population densities.The impact of large,wild herbivores on grassland should not be ignored.Livestock overgrazing is another main factor,to some extent,grazing intensity directly determines the degree of grassland degradation.Although the main causes of grassland degradation vary across different regions,the main causes of grassland degradation in Qinghai-Tibet Plateau are overgrazing and population eruptions of small mammals.Things should be concerned in grassland rehabilitation and management were presented in allusion to the cause of degradation.
Intermingling and seasonal migrations of Greenland halibut (Reinhardtius hippoglossoides) populations determined from tagging studies

A total of 7244 Greenland halibut (Reinhardtius hippoglossoides, Walbaum) were tagged in Greenland waters between 1986 and 1998 to increase information on stock delineations, to clarify migration routes, and to describe the seasonal movements of fjord populations. At present 517 recaptured Greenland halibut have been recorded. For Greenland halibut released in Davis Strait, Baffin Bay, and the fjords of southwestern and eastern Greenland, a substantial portion of recovered fish demonstrated migratory behavior, up to 2500 km, primarily to Denmark Strait between Greenland and Iceland. The recaptured fish provided evidence of intermingling between the population in Denmark Strait and the populations in Davis Strait and the southwest Greenland fjords. These observations support those of other studies that indicate that Greenland halibut inhabiting Davis Strait and the fjords of southwestern and eastern Greenland originate in the spawning grounds west of Iceland. The high mobility of offshore Greenland halibut within Baffin Bay and Davis Strait suggests that Greenland halibut migrate extensively between feeding and spawning areas. Greenland halibut in the fjords of northwestern Greenland appear to be resident in behavior and do not intermingle with offshore or more southerly inshore populations. A seasonal pattern in the recovery of these fish indicates that Greenland halibut aggregate in the inner part of fjords during the second half of the year (when inshore waters are not covered with ice).
Addressing Comorbidities in People with Parkinson’s Disease: Considerations From An Expert Panel

In the UK, guidance exists to aid clinicians and patients deciding when treatment for Parkinson’s disease (PD) should be initiated and which therapies to consider. National Institute for Health and Care Excellence (NICE) guidance recommends that before starting PD treatment clinicians should discuss the following: the patient’s individual clinical circumstances; lifestyle; preferences; needs and goals; as well as the potential benefits and harms of the different drug classes. Individualization of medicines and management in PD significantly improves patients’ outcomes and quality of life. This article aims to provide simple and practical guidance to help clinicians address common, but often overlooked, co-morbidities. A multi-disciplinary group of PD experts discussed areas where clinical care can be improved by addressing commonly found co-morbidities in people with Parkinson’s (PwP) based on clinical experience and existing literature, in a roundtable meeting organized and funded by Bial Pharma UK Ltd. The experts identified four core areas (bone health, cardiovascular risk, anticholinergic burden, and sleep quality) that, if further standardized may improve treatment outcomes for PwP patients. Focusing on anticholinergic burden, cardiac risk, sleep, and bone health could offer a significant contribution to personalizing regimes for PwP and improving overall patient outcomes. Within this opinion-based paper, the experts offer a list of guiding factors to help practitioners in the management of PwP.
Intramembrane protease SPP defines a cholesterol-regulated switch of the mevalonate pathway

Intramembrane proteolysis regulates important processes such as signaling and transcriptional and posttranslational abundance control of proteins with key functions in metabolic pathways. This includes transcriptional control of mevalonate pathway genes, thereby ensuring balanced biosynthesis of cholesterol and other isoprenoids. Our work shows that, at high cholesterol levels, signal peptide peptidase (SPP) cleaves squalene synthase (SQS), an enzyme that defines the branching point for allocation of isoprenoids to the sterol and non-sterol arms of the mevalonate pathway. This intramembrane cleavage
Circumstellar Disk Accretion Across the Lagoon Nebula: The Influence of Environment and Stellar Mass

Pre-main-sequence disk accretion is pivotal for determining the final stellar properties and the early conditions for close-in planets. We aim to establish the impact of internal (stellar mass) and external (radiation field) parameters on the disk evolution in the Lagoon Nebula massive star-forming region. We employ simultaneous u, g, r, i, Hα time-series photometry, archival infrared data, and high-precision K2 light curves to derive the stellar, disk, and accretion properties for 1012 Lagoon Nebula members. We estimate that of all young stars in the Lagoon Nebula, 34%–37% have inner disks traceable down to ∼12 μm, while 38%–41% are actively accreting. We detect disks ∼1.5 times more frequently around G, K, and M stars than around higher-mass stars, which appear to deplete their inner disks on shorter timescales. We find tentative evidence for a faster disk evolution in the central regions of the Lagoon Nebula, where the bulk of the O/B population is located. Conversely, disks appear to last longer at the nebula outskirts, where the measured fraction of disk-bearing stars tends to exceed that of accreting and disk-free stars. The derived mass accretion rates show a nonuniform dependence on stellar mass between ∼0.2 and 5 M ⊙. In addition, the typical accretion rates appear to differ across the Lagoon Nebula extension, with values twice lower in the core region than at its periphery. Finally, we detect tentative radial density gradients in the surface accretion shocks, leading to lags in the appearance of light curve brightness features as a function of wavelength that can amount to ∼7%–30% of the rotation period.