Miracle-dz/UniFAR-FTUs huggingface dataset:
Citizen Science Mosquito Surveillance by Ad Hoc Observation Using the iNaturalist Platform

Citizen science mosquito surveillance has been growing in recent years due to both increasing concern about mosquito-borne disease and the increasing popularity of citizen science projects globally. Health authorities are recognising the potential importance of citizen science to expanding or enhancing traditional surveillance programs. Different programs have shown success in engaging communities to monitor species of medical importance through low-cost methods. The Mozzie Monitors project was established on iNaturalist—an open citizen science platform that allows participants to upload photos (i.e., observers) and assist identification (i.e., identifiers). This article describes the likelihood of citizen scientists submitting photos of mosquitoes, assesses user submission behaviour, and evaluates public health utility from these citizen science-derived data. From October 2018 to July 2021, the Mozzie Monitors project on iNaturalist received 2118 observations of 57 different species of mosquitoes across Australia. The number of observers in the system increased over time with more than 500 observers and 180 identifiers being active in the project since its establishment. Data showed species bias with large-bodied and colourful mosquitoes being over-represented. Analyses also indicate regional differentiation of mosquito fauna per state, seasonality of activity, and ecological information about mosquitoes. The iNaturalist citizen science platform also allows connectedness, facilitated communication and collaboration between overall users and expert entomologists, of value to medical entomology and mosquito management.
Dietary Crude Fiber Levels for Optimal Productivity of Male Ross 308 Broiler and Venda Chickens Aged 1 to 42 Days

Simple Summary Crude fiber levels that are not controlled in chicken diets could have adverse effects on productivity. The use of alternative protein resources in commercial broiler and indigenous chicken production often has limitations in terms of dietary crude fiber. Evidence suggests that there might be differences in the way chicken breeds cope with dietary crude fiber, which ultimately affects the production potentials. The study determined the levels of dietary crude fiber that enhanced the productivity in Ross 308 broiler and indigenous Venda chickens. Results showed that both chicken breeds aged 1 to 42 days required dietary crude fiber for enhanced productivity. However, indigenous Venda chickens required higher dietary CF levels in order to improve the production performance than the Ross 308 broiler chickens. Thus, it was concluded that the indigenous chickens were able to cope when challenged with higher dietary crude fiber levels. Abstract The study determined the effects of dietary crude fiber (CF) levels on the production performance of male Ross 308 broiler and indigenous Venda chickens. There were 360 male Ross 308 broiler and male Venda chickens aged 1–21 for Phase 1 and 196 chickens aged 22–42 days for Phase 2. Chickens were allocated four diets with different levels of CF (3, 4, 5, and 7%) in a completely randomized design. Quadratic regression analyses were used to determine the dietary CF levels for the optimal production responses. In Phase 1, the feed intake, growth, live weight, nitrogen retention, and metabilizable energy (ME) intake of the Ross 308 broiler chickens were improved at dietary CF levels of 3.9, 4.5, 4.5, 3.2, and 3.7%, respectively. In the Venda chickens, feed intake, growth, live weight, nitrogen retention, and ME intake were optimized at 4.4, 4.8, 4.7, 4.1, and 3.3% CF, respectively. In Phase 2, the feed intake, nitrogen retention, and neutral detergent fiber digestibility (NDFD) were enhanced at CF levels of 6.4, 4.4, and 3.7% in the Ross 308 broiler chickens, respectively. Dietary CF levels of 4.5, 5.8, 5.7, 5.1, 3.9, and 4.4% optimized the feed intake, growth rate, live weight, nitrogen retention, NDF, and ADFD, respectively, in Venda chickens. It was concluded that the indigenous Venda chickens coped better with higher dietary CF than the Ross 308 broiler chickens.
Who Killed the Phillips Curve? A Murder Mystery

Is the Phillips curve dead? If so, who killed it? Conventional wisdom has it that the sound monetary policy since the 1980s not only conquered the Great Inflation, but also buried the Phillips curve itself. This paper provides an alternative explanation: labor market policies that have eroded worker bargaining power might have been the source of the demise of the Phillips curve. We develop what we call the "Kaleckian Phillips curve", the slope of which is determined by the bargaining power of trade unions. We show that a nearly 90 percent reduction in inflation volatility is possible even without any changes in monetary policy when the economy transitions from equal shares of power between workers and firms to a new balance in which firms dominate. In addition, we show that the decline of trade union power reduces the share of monopoly rents appropriated by workers, and thus helps explain the secular decline of labor share, and the rise of profit share. We provide time series and cross sectional evidence.
Comparison Study of Myocardial Radiomics Feature Properties on Energy-Integrating and Photon-Counting Detector CT

The implementation of radiomics-based, quantitative imaging parameters is hampered by a lack of stability and standardization. Photon-counting computed tomography (PCCT), compared to energy-integrating computed tomography (EICT), does rely on a novel detector technology, promising better spatial resolution and contrast-to-noise ratio. However, its effect on radiomics feature properties is unknown. This work investigates this topic in myocardial imaging. In this retrospective, single-center IRB-approved study, the left ventricular myocardium was segmented on CT, and the radiomics features were extracted using pyradiomics. To compare features between scanners, a t-test for non-paired samples and F-test was performed, with a threshold of 0.05 set as a benchmark for significance. Feature correlations were calculated by the Pearson correlation coefficient, and visualization was performed with heatmaps. A total of 50 patients (56% male, mean age 56) were enrolled in this study, with equal proportions of PCCT and EICT. First-order features were, nearly, comparable between both groups. However, higher-order features showed a partially significant difference between PCCT and EICT. While first-order radiomics features of left ventricular myocardium show comparability between PCCT and EICT, detected differences of higher-order features may indicate a possible impact of improved spatial resolution, better detection of lower-energy photons, and a better signal-to-noise ratio on texture analysis on PCCT.
ONOS Flood Defender: An Intelligent Approach to Mitigate DDoS Attack in SDN

Software‐Defined Networking (SDN) has made its place in the networks as new technology. SDN's programmable behavior enables it to change behavior on the fly, provides instructions for the task's automatic performance, dynamic scaling, and service integration. These advantages have made SDN necessary in networks. However, SDN suffers from the threat of DDoS attack. We have developed an approach to mitigate these threats by creating an ONOS Flood Defender Application (OFD App). This app effectively detects DDoS attack using supervised and ensemble machine learning techniques and mitigates them by tracebacking the attack traffic to its origin. Our results show that ensemble machine learning techniques perform better than single machine learning algorithm to detect DDoS attack. Random Forest classifier (RFC), an ensemble technique, performs best with the highest accuracy of 99.3% in detecting DDoS attack, followed by XGBoost classifier with an accuracy of 99%. The proposed framework of the OFD app is implemented in a Mininet emulator and ONOS SDN controller. The application performs effectively in terms of time, accuracy, and overhead of the system. Our app efficiently mitigates the attacks, thereby preventing a tremendous amount of damage to legitimate users.
HTR1A Gene Polymorphism in Type 2 Diabetes Mellitus Comorbid with Major Depressive Disorder in a Chinese Population

Background Major depressive disorder is a frequent mental illness, which is common in patients with type 2 diabetes. Type 2 diabetes comorbid with depression has a worse prognosis. There are multiple risk factors for depression, and genetic studies have shown that gene polymorphism may play an important role in the pathogenesis of depression. Methods A total of 874 patients with type 2 diabetes were recruited for this study and divided into two groups: depressive group (DDM group, n = 234) and non-depressive group (NDDM group, n = 640). HTR1A gene polymorphisms (rs6295, rs878567, rs1800044) genotyping work was performed using a custom by design 48-Plex SNPscanTM Kit. Results The rs6295, rs878567, and rs1800044 SNPs were not associated with type 2 diabetes comorbid with depression. Female sex, age, and FBG level increased the risk of depression in patients with type 2 diabetes. Conclusion HTR1A rs6295, rs878567, and rs1800044 SNPs polymorphism is not associated with type 2 diabetes comorbid with depression. Rather, female sex, age, and FBG level are risk factors for depression among patients with type 2 diabetes. Larger studies are needed to further confirm our findings.
OncoPan®: An NGS-Based Screening Methodology to Identify Molecular Markers for Therapy and Risk Assessment in Pancreatic Ductal Adenocarcinoma

Pancreatic cancer has a high morbidity and mortality with the majority being PC ductal adenocarcinomas (PDAC). Whole genome sequencing provides a wide description of genomic events involved in pancreatic carcinogenesis and identifies putative biomarkers for new therapeutic approaches. However, currently, there are no approved treatments targeting driver mutations in PDAC that could produce clinical benefit for PDAC patients. A proportion of 5–10% of PDAC have a hereditary origin involving germline variants of homologous recombination genes, such as Mismatch Repair (MMR), STK11 and CDKN2A genes. Very recently, BRCA genes have been demonstrated as a useful biomarker for PARP-inhibitor (PARPi) treatments. In this study, a series of 21 FFPE PDACs were analyzed using OncoPan®, a strategic next-generation sequencing (NGS) panel of 37 genes, useful for identification of therapeutic targets and inherited cancer syndromes. Interestingly, this approach, successful also on minute pancreatic specimens, identified biomarkers for personalized therapy in five PDAC patients, including two cases with HER2 amplification and three cases with mutations in HR genes (BRCA1, BRCA2 and FANCM) and potentially eligible to PARPi therapy. Molecular analysis on normal tissue identified one PDAC patient as a carrier of a germline BRCA1 pathogenetic variant and, noteworthy, this patient was a member of a family affected by inherited breast and ovarian cancer conditions. This study demonstrates that the OncoPan® NGS-based panel constitutes an efficient methodology for the molecular profiling of PDAC, suitable for identifying molecular markers both for therapy and risk assessment. Our data demonstrate the feasibility and utility of these NGS analysis in the routine setting of PDAC molecular characterization.
Convection of multi-scale motions in turbulent boundary layer by temporal resolution particle image velocimetry

Experiments of particle image velocimetry (PIV) in the turbulent boundary layer at have been conducted to investigate the convection characteristic of turbulent structure and the validity of Taylor’s hypothesis. Views of ( , the boundary layer thickness) were captured by four streamwise-arranged cameras. Distributions of streamwise turbulent kinetic energy on a streamwise scale were investigated by continuous-wave transform, and scales were found where the portion of streamwise turbulent kinetic energy approaches maximum. Fluctuating velocities (instant velocity minus average velocity on time dimension) were divided into large-scale motion (LSM) and small-scale motion (SSM) portions, bounded by . Convection velocities of LSM and SSM are determined by the spatiotemporal correlation method, and they are larger than local average velocities in near-wall regions, but smaller than local average velocities in wake regions. Statistical characteristics between velocity fields reconstructed by Taylor’s hypothesis and original fields were compared by the autocorrelation method, and the reconstructed field’s patterns are longer than original field’s patterns, while their heights do not have clear distinction. The correlation of original velocity fields and reconstructed fields shows that LSM can hold on over and SSM over in streamwise convection separation for regions of , given a threshold value (correlation coefficient C = 0.6).
Jurors' Perceptions of Child Sexual Abuse Disclosure Patterns

The process of child disclosure of sexual abuse can be complex. Children often disclose abuse consistently across settings (continuous disclosure), though there is research to support that children may deny abuse or recant their allegations despite the abuse having truly occurred (London et al., 2008; Bradley & Wood, 1996; Malloy, Lyon, & Quas, 2007). In this study, data was collected from voluntary MTurk users ( N = 688). Mock jurors responded to a survey assessing perceptions of child credibility, defendant guilt, and child susceptibility to external influence in response to each CSA disclosure pattern (continuous disclosure, denial, recantation). Additionally, expert witness testimony regarding typical child disclosure processes (present or absent) and child age (4- or 8-years-old) acted as independent variables. A number of significant results emerged with respect to disclosure patterns and expert witness presence. Forensic implications and future directions are discussed.
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases

Abstract Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. Interventions targeting microglia have been shown to improve the prognosis of various neurological diseases. Recently, studies have observed the activation of microglia in different cardiovascular diseases. In addition, different approaches that regulate the activity of microglia have been shown to modulate the incidence and progression of cardiovascular diseases. The change in autonomic nervous system activity after neuroinflammation may be a potential intermediate link between microglia and cardiovascular diseases. Here, in this review, we will discuss recent updates on the regulatory role of microglia in hypertension, myocardial infarction and ischemia/reperfusion injury. We propose that microglia serve as neuroimmune modulators and potential targets for cardiovascular diseases.
Carer perceptions of a specialist mental health service for children and young people in care

Introduction: Children and young people in care are a key client group for child and youth mental health services. A collaborative approach to addressing the complex and long-term needs of children or young people in care is essential and carers who support these children or young people are vital team members of this collaboration. Method: This research surveyed carers over a 4-year period to gather feedback about a specialist mental health service. 277 carers responded to the Carer Perceptions Survey. Participants were mainly foster (65%) and kinship (17%) carers. However, residential workers (13%) and biological parents (5%) also responded to the survey. A thematic analysis was undertaken with responses to open-ended questions about most liked aspects of the service and ideas for service improvement. Results: Themes included support for carers, communication between carers and staff, personal attributes of staff, working in collaboration, accessibility to the service, and carer training. Carers expressed their appreciation of staff who provided support in collaborative and respectful ways and valued staff who listened to their experiences and ideas. In addition, carers expressed interest in receiving more information and training about how best to support the mental health of children and young people in their care. Conclusion: Effective mental health services for children and young people in care require clinical staff that foster respectful engagement and facilitate collaboration with carers in all aspects of care.
Low-Frequency Oscillations of In Vivo Ambient Extracellular Brain Serotonin

Serotonin is an important neurotransmitter that plays a major role in many aspects of neuroscience. Fast-scan cyclic voltammetry measures fast in vivo serotonin dynamics using carbon fiber microelectrodes. More recently, fast-scan controlled-adsorption voltammetry (FSCAV) has been developed to measure slower, minute-to-minute changes in ambient extracellular serotonin. We have previously demonstrated that FSCAV measurements of basal serotonin levels give critical information regarding brain physiology and disease. In this work, we revealed the presence of low-periodicity fluctuations in serotonin levels in mouse hippocampi, measured in vivo with FSCAV. Using correlation analyses, we found robust evidence of oscillations in the basal serotonin levels, which had a period of 10 min and were not present in vitro. Under control conditions, the oscillations did not differ between male and female mice, nor do they differ between mice that underwent a chronic stress paradigm and those in the control group. After the acute administration of a selective serotonin reuptake inhibitor, we observed a shift in the frequency of the oscillations, leading us to hypothesize that the newly observed fluctuations were transporter regulated. Finally, we optimized the experimental parameters of the FSCAV to measure at a higher temporal resolution and found more pronounced shifts in the oscillation frequency, along with a decreased oscillation amplitude. We postulate that this work may serve as a potential bridge for studying serotonin/endocrine interactions that occur on the same time scale.
Autologous Stem-Cell Transplantation for High-Risk Neuroblastoma: Historical and Critical Review

Simple Summary The original idea that providing higher doses of cytotoxic agents will result in higher rates of tumor cell killing was proposed in the 1980s. Preclinical data supported clinical testing. Advancements in bone marrow and peripheral stem-cell support technologies during the 1980s and 1990s allowed for clinical developments that permitted testing the higher dose hypothesis in oncology patients. The results of almost 20 years of clinical trials proved the linear relationship between dosing and clinical outcome to be mostly inaccurate. As a consequence, the adult oncology field abandoned high-dose chemotherapy strategies by the turn of the 21st century. Neuroblastoma is the only pediatric extracranial solid tumor where high-dose chemotherapy has remained part of the standard management for high-risk cases. This systematic review aims to understand the historical reason for such an exception and analyzes data challenging the benefit of high-dose chemotherapy and autologous stem-cell transplants in the era of anti-GD2 immunotherapy. Abstract Curing high-risk neuroblastoma (HR-NB) is a challenging endeavor, which involves the optimal application of several therapeutic modalities. Treatment intensity for cancer became highly appealing in the 1990s. Investigative trials assumed that tumor response correlated with the dosage or intensity of drug(s) administered, and that this response would translate into improved survival. It was postulated that, if myelotoxicity could be reversed by stem-cell rescue, cure might be possible by increasing the dose intensity of treatment. The principle supported autologous stem-cell transplant (ASCT) strategies. High-dose therapy transformed clinical practice, legislation, and public health policy, and it drove a two-decade period of entrepreneurial oncology. However, today, no ASCT strategies remain for any solid tumor indication in adults. As with most solid malignancies, higher dosing of cytotoxic agents has not resulted in a clear benefit in survival for HR-NB patients, whereas the long-term toxicity has been well defined. Fortunately, novel approaches such as anti-GD2 immunotherapy have demonstrated a significant survival benefit with a much less adverse impact on the patient’s wellbeing. On the basis of extensive experience, persisting with administering myeloablative chemotherapy as the standard to treat children with HR-NB is not consistent with the overall aim in pediatric oncology of curing with as little toxicity as possible.
The Mars Oxygen Visible Dayglow: A Martian Year of NOMAD/UVIS Observations

The Ultraviolet and Visible Spectrometer Ultraviolet (UVIS UV) and Visible Spectrometer channel of the Nadir and Occultation for MArs Discovery spectrometer aboard the ExoMars Trace Gas Orbiter has made limb observations of the Martian dayglow during more than a Martian year. Two pointing modes have been applied: (a) In the inertial mode, the spectrometer scans the atmosphere twice down to near the surface and provides altitude profiles of the dayglow; (b) in the tracking mode, the atmosphere is scanned at varying latitudes at a nearly constant altitude through the entire observation. We present a statistical study of the vertical and seasonal distribution of the recently discovered oxygen green and red lines at 557.7 nm and 630 nm. It indicates that the brightness of the green line emission responds to changes in the Lyman‐α flux. The peak altitude of the green line emission increases seasonally when the Sun‐Mars distance decreases. The lower peak of the green line statistically drops by 15–20 km between perihelion and aphelion at mid‐to high altitude. The main lower peak intensity shows an asymmetry between the two hemispheres. It is significantly brighter and more pronounced in the southern hemisphere than in the north. This is a consequence of the stronger Lyman‐α solar flux near perihelion. The second component of the oxygen red line at 636.4 nm is also detected for the first time in the Martian atmosphere. A photochemical model is used to simulate the variations of the green dayglow observed along limb tracking orbits.
Perceiving and managing Brexit risk in UK manufacturing: evidence from the midlands

ABSTRACT This paper assesses the risk implications of Brexit for UK-based, manufacturers, drawing on data generated from semi-structured interviews with senior managers and directors in the advanced manufacturing sector of the West Midlands region of the UK in 2021. The UK’s departure from the EU has led to increased socio-economic risk for manufacturing businesses, requiring careful management by the latter. This paper draws on elements of the Kasperson et al. [1988. The social amplification of risk: A conceptual framework. Risk Analysis, 8(2), 177–187] Social Amplification of Risk Framework (SARF) to explore the communication of risk and uncertainty to businesses, during and post-Brexit discussions. This paper then examines the extent to which risk arises from changes to supply chains and production regimes and in turn examines consequences for the management of risk.