Miracle-dz/UniFAR-FTUs huggingface dataset:
PHMT_A_257804 171..178

Adane Asefa 1 Qaro Qanche 1 Zufan Asaye Lemi Abebe 1 1Department of Public Health, College of Health Science, Mizan-Tepi University, Mizan Aman, Ethiopia; 2Department of Statistics, College of Natural Science, Mizan-Tepi University, Tepi, Ethiopia Background: Although there are low cost and effective interventions to prevent and treat diarrhea, it is one of the leading causes of morbidity and mortality among under-five children in developing countries. Deaths from diarrheal diseases are largely due to lack of prompt seeking of medical care. This study aimed to identify determinants of delayed treatmentseeking for diarrheal diseases among under-five children in Southwest Ethiopia. Methods: Unmatched case–control study was conducted among 324 under-five children paired with their mothers/caregivers from 1st April to 30th May 2019. Cases were under-five children paired with their mothers/caregivers who sought treatment after 24 hours of the onset of signs and symptoms of diarrheal diseases, and controls were under-five children paired their mothers/caregivers who sought treatment within 24 hours of the onset of signs and symptoms of diarrheal diseases. Consecutive sampling was used, and data were collected through interviews and chart reviews. Multivariable binary logistic regression analysis was performed, and variables with a P-value <0.05 were considered statistically significant. Results: A total of 324 (162 cases and 162 controls) under-five children paired with their mothers/caregivers were included in this study. Being rural residents (AOR=1.93, 95% CI: 1.13,3.31), children from households with more than two children (AOR=2.05, 95% CI: 1.15– 3.66), preferring traditional healers for the treatment of diarrhea (AOR= 4.78, 95% CI: 1.74,13.12), not having television or radio for the households (AOR=2.05, 95% CI: 1.11– 3.66), living in more than 10 km from the nearest health facility (AOR=4.80, 95% CI: 2.61– 4.83), and perceiving diarrhea can cure without treatment (AOR=2.11, 95% CI: 1.15–3.87) were significant determinants of delayed treatment-seeking. Conclusion: Being rural residents, larger family size, physical inaccessibility of health facilities, not having access to electronic media (television or radio), preferring traditional healers for the treatment of diarrhea, and having the perception that diarrhea can be cured without treatment were determinants of delayed treatment-seeking for diarrheal diseases among under-five children. Thus, multidimensional approaches that can address accessibility of health facilities and improve caregivers’ awareness are necessary to encourage prompt treatment-seeking for diarrheal diseases among under-five children.
CMAR_A_267825 10531..10540

1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 2Central Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Purpose: This study provides an overview of the prognosis of intravascular large B cell lymphoma (IVLBCL) over the past 10 years and analyzes the possible relevant factors. Patients and Methods: We conducted a literature search of case reports, case series, and retrospective studies of IVLBCL published from January 2008 to July 2018. After excluding inappropriate data, 103 publications were selected for the analysis. Statistical analyses of different treatment modalities, the effect of blood–brain barrier (BBB)-penetrating drugs, and prognostic factors for outcomes were performed. Results: In total, 182 pathologically confirmed cases of IVLBCL were included in our study. The results revealed that the 1and 3-year overall survival rates were 42.3 and 11.5%, respectively, whereas the median overall survival was 340 days. Overall survival (450 days vs 180 days) and progression-free survival (420 days vs 150 days) were significantly longer in patients who received rituximab-containing regimens than in those treated with other regimens. For IVLBCL involving the CNS, regimens containing BBB-penetrating drugs failed to provide an additional survival benefit. In addition, lactic dehydrogenase levels ≥700 U/L, CNS involvement, and hemophagocytic syndrome were identified as unfavorable risk factors in patients with IVLBCL, whereas skin involvement appeared to be a protective factor. Conclusion: Rituximab-containing chemotherapy can improve the outcomes of patients with IVLBCL, but the prognosis remains unsatisfactory. Treatment regimens containing BBB-penetrating drugs failed to improve outcomes in patients with CNS-involved IVLBCL. Several factors affect the prognosis of patients with IVLBCL, and further research on the underlying mechanisms is needed.
Evaluation of Sport Sponsorship as an Element of Sport Marketing Mix

Companies' sponsorship has been increasing as an element of marketing mix communication and has become a major source of funding for special and non-going (common) sporting events. However sponsors may have been doubted regarding their investment in such events. Due to the present study investigates the main objectives of the sponsoring companies in sport and compares views of company and sport managers. The data collection instrument was a tailor-made questionnaire which was accepted by experts group (r=0.84). The statistical population of this study was all managers of factories and private companies, club manager and sport headquarters in East Azerbaijan. Data was analyzed through the descriptive and inferential statistics (U Mann Whitney) in significant level P<0.05. Results indicated significant difference among managers views regarding: development public awareness, facilitate of sales, better relationship with the government, gaining more profit, suitable way for advertising, obtaining tax-exemptions due to economic advertising in sports and close relation of the company product to sport type (P<0.05). while there was no significant difference among the groups in terms of the other goals related to product, sales objectives, general objectives and the criteria to select group sports (P>0.05). Finally sport authorities should make appropriate decision for attracting more sports sponsorships. Due to attract more financial supporters, appropriate plans can be designed and this can help to promote private companies attention to sport so that they can benefit from their sponsorship.
Explorer To Buy or Not to Buy ?

This paper examines the interaction of law and policy making on prostitution, with that of BDSM (bondage and discipline, sadism and masochism). Recent policy and legal shifts in the UK mark out prostitutes as vulnerable and in need of ‘rescue’. BDSM that amounts to actual bodily harm is unlawful in the UK, and calls to decriminalise it are often met with fears that participants will be left vulnerable to abuse. Where women sell BDSM sex, even more complex questions of choice, exploitation, vulnerability, power and agency might be thought to arise. Does the combination of activities take two singular behaviours into the realm of compound harm? Are those who sell BDSM doubly vulnerable in a way that would justify criminal intervention? This paper argues that in imposing categories of vulnerability, the state engages in the heteronormative construction of risky sexual subjects who must be rehabilitated, responsiblised or punished. Through an examination of existing empirical studies on BDSM, the paper offers a feminist critique of the potential criminalisation of commercial BDSM and calls for more research on the lived experiences of those who buy and sell BDSM.
Mandatory Financial Reporting and Voluntary Disclosure: The Effect of Mandatory IFRS Adoption on Management Forecasts

This study examines the effect of the mandatory adoption of International Financial Reporting Standards (IFRS) on voluntary disclosure. Using a difference-in-difference analysis, we document a significant increase in the likelihood and frequency of management earnings forecasts following mandatory IFRS adoption, consistent with the notion that IFRS adoption alters firms’ disclosure incentives in response to increased capital-market demand. We find the increase to be larger among firms domiciled in code-law countries, suggesting a catching-up effect among firms facing low disclosure incentives pre-adoption. We then propose and test three channels through which IFRS adoption could alter firms’ disclosure incentives: improved earnings quality, increased shareholder demand, and increased analyst demand. We find evidence consistent with all three channels.
ROLE OF FETUIN-A AND HSCRP IN CVD RISK IN HYPOTHYROIDISM IRAQI WOMEN

Hypothyroidism is one of the common endocrine disorders that is associated with cardiovascular diseases, it is more common in women with female: male ratio reaches up to 6:1. Hypothyroidism could be regarded as inflammatory condition and Systemic inflammation was emerged as a risk factor for cardiovascular disease. To study the association of serum levels of fetuin-A with TSH, FT4, T4, T3 and hsCRP as an inflammatory marker 46 patients aged ≥ 30 years were consecutively selected after have been diagnosed as hypothyroidism. Healthy (N = 42), age and sex-matched subjects as controls. Clinical characteristics were recorded and serum levels of lipid profile, fetuin-A, TSH, FT4, T4, T3 and hsCRP were measured. Fetuin-A was significantly decreased in hypothyroid individuals while, hsCRP, LDL-c and atherogenic index were significantly higher in the same group compared with control. No significant correlations were observed for Fetuin-A or hsCRP with thyroid function test and classical lipid profile measure. However, atherogenic index showed highly significant correlations with TSH. The results of our study showed that all aspects of increasing risk factors of cardiovascular disease were observed in newly diagnosed Iraqi women with hypothyroidism represented by; increase systemic inflammation, disarranged lipid profile and an increasing vascular calcification risk.
Color correspondence of different brands and composite resin systems in relation to the Vita Classical scale through spectrophotometry

Introduction: The color matching between aesthetic materials and dental structure is certainly the parameter most used by patients to evaluate the quality of the aesthetic treatments performed, influencing decisively the judgment of professional competence and the degree of patient satisfaction at the end of the treatment. Objective: To identify among the composite resins, which present greater color matching with the Vita Classical scale. Method: Six groups were formed; the Tetric N-Flow® color A1 resin was used as light control and the Tetric N-Flow® A4 color as dark control and 4 A2D color resins (Oplais, Empress Direct, Esthelite and Z350). For each material, ten specimens were prepared. The reading of each test specimen was performed through a spectrophotometer and then annotated the CIELab standard, in addition to reading through the hue and chroma. A visual evaluation was performed between 4 evaluators so that they could check the resins against the light and dark patterns. Results: The tonality of each specimen presented a low percentage of correspondence, in relation to the A2 color of the Vita scale. The ΔE values of the groups and the A2 range of the Vita scale were submitted to statistical analysis with 5% significance. ANOVA resulted in statistically significant differences for all sample groups (p <0.05). The Tukey test showed no color match between the analyzed materials and the reference hue of the Vita scale. Conclusion: there was no color match with the reference A2 of the Vita scale; the differences of composition and manufacturers result in colors that are close but different. *Correspondence to: Diogo de Azevedo Miranda, Rua Sampaio 330/602, Granbery, Juiz de Fora, Minas Gerais 36010-360, Brazil, E-mail: diogoodonto@yahoo.com. br
EB_A_337333 35..48

Purpose: To evaluate the relationship between different macular thickness parameters analyzed by SD-OCT and the central visual field (VF) evaluated with automated kinetic perimetry in a cohort of patients with pituitary tumors. Methods: Data from patients with pituitary adenoma treated at Reims University Hospital between October 1st, 2017, and May 31st, 2018 were collected. All patients underwent an automated kinetic perimetry and a SD-OCT to map the ganglion cell complex (GCC), the ganglion cell layer (GCL) thickness and the retinal nerve fiber layer (RNFL) using devices from two different manufacturers. Univariate and multivariate analysis were used to evaluate the correlation between the area of central VF in square degrees (deg2) and the SD-OCT parameters (μm). Results: Eighty-eight eyes were included in the analysis. All the thickness parameters measured in SD-OCT decreased with the visual field alteration. The best correlation was observed between superior thickness parameters (GCC, GCL) and the inferior central visual field. The most pertinent predictive factors for visual field loss were the inferior central GCL and the nasal RNFL (both AUC=0.775) with a sensitivity respectively of 86% and 70%. Conclusion: This study suggests that both GCC, GCL thickness parameters could be reliable predictors of central visual field impairment in patients with pituitary tumors. There was no significative difference between both devices.
Matrix product states for critical spin chains: finite size scaling versus finite entanglement scaling

We investigate the use of matrix product states (MPS) to approximate ground states of critical quantum spin chains with periodic boundary conditions (PBC). We identify two regimes in the (N,D) parameter plane, where N is the size of the spin chain and D is the dimension of the MPS matrices. In the first regime MPS can be used to perform finite size scaling (FSS). In the complementary regime the MPS simulations show instead the clear signature of finite entanglement scaling (FES). In the thermodynamic limit (or large N limit), only MPS in the FSS regime maintain a finite overlap with the exact ground state. This observation has implications on how to correctly perform FSS with MPS, as well as on the performance of recent MPS algorithms for systems with PBC. It also gives clear evidence that critical models can actually be simulated very well with MPS by using the right scaling relations; in the appendix, we give an alternative derivation of the result of Pollmann et al. [Phys. Rev. Lett. 102, 255701 (2009)] relating the bond dimension of the MPS to an effective correlation length.
DMD056713 974..982

Apicidin, a potential oral chemotherapeutic agent, possesses potent anti-histone-deacetylase activity. After oral administration, the total bioavailability of apicidin is known to be low (14.2%– 19.3%). In the present study, we evaluated the factors contributing to the low bioavailability of apicidin by means of quantitative determination of absorption fraction and first-pass metabolism after oral administration. Apicidin was given to rats by five different routes: into the femoral vein, duodenum, superior mesenteric artery, portal vein, and carotid artery. Especially, the fraction absorbed (FX) and the fraction that is not metabolized in the gut wall (FG) were separated by injection of apicidin via superior mesenteric artery, which enables bypassing the permeability barrier. The FX was 45.9% 6 9.7%, the FG was 70.9% 6 8.1% and the hepatic bioavailability (FH) was 70.6% 6 12.3%, while the pulmonary firstpass metabolism was minimal (FL = 102.8%6 7.4%), indicating that intestinal absorption was the rate-determining step for oral absorption of apicidin. The low FX was further examined in terms of passive diffusion and transporter-mediated efflux by in vitro immobilized artificial membrane (IAM) chromatographic assay and in situ single-pass perfusion method, respectively. Although the passive diffusion potential of apicidin was high (98.01%) by the IAM assay, the in situ permeability was significantly enhanced by the presence of the P-glycoprotein (P-gp) inhibitor elacrider. These data suggest that the low bioavailability of apicidin was mainly attributed to the P-gp efflux consistent with the limited FX measured in vivo experiment.
A study on refractive errors in school children with complaints of headache in a rural tertiary care hospital

Purpose: To evaluate refractive errors among school children with complaints of headache and to compare it with children without headache. Methods: This is a prospective cross-sectional study of 414 school children with complaints of headache, aged between 12 and 18 years and 414 children of same age group without headache as control group. Headache complaints were measured by a structured questionnaire. All children underwent a comprehensive ophthalmological examination. Both subjective and objective refraction was done for all children. They were classified into three groups according to refractive errors; myopia, hypermetropia and astigmatism. Results: The study included 252(60.87%) girls and 162(39.13%) boys with headache and 227(54.83%) girls and 187(45.17%) boys without headache as control group. Mean age of the participants was 13.71± 2.21 years in headache group and 14.45±1.96 years in control group. Among 228(55.1%) children in headache group with refractive errors, 28(12.3%) had myopia, 61(26.8%) had hypermetropia and 139(60.9%) had astigmatism. Out of 72(17.39%) children in control group with refractive errors, 48(66.7%) had myopia, 14(19.4%) had hypermetropia and 10(13.9%) had astigmatism. We observed that refractive error is a risk factor for headache among children with odds ratio 5.38 in comparison to control group and difference was statistically significant (p<0.05). Conclusions: This study enhances our understanding of the relationship of headache and refractive errors to improve opportunities for its treatment and prevention. An ophthalmologist can play a vital role in the control of headache complaints in
Transgenic tobacco plants overexpressing chitinases of fungal origin show enhanced resistance to biotic and abiotic stress agents

Genes encoding defense-related proteins have been used to alter the resistance of plants to pathogens and other environmental challenges, but no single fungal gene overexpression has produced broad-spectrum stress resistance in transgenic lines. We have generated transgenic tobacco lines that overexpress the endochitinases CHIT33 and CHIT42 from the mycoparasitic fungus Trichoderma harzianum , and have evaluated their tolerance to biotic and abiotic stress. Both CHIT33 and CHIT42, individually, conferred broad resistance to fungal and bacterial pathogens, salinity and heavy metals. Such broad-range protective effects came off with no obvious detrimental effect on the growth of tobacco plants
ACELL May 47/5

Zólyomi, Annamária, Xiaohang Zhao, Gregory J. Downing, and Tamas Balla. Localization of two distinct type III phosphatidylinositol 4-kinase enzyme mRNAs in the rat. Am J Physiol Cell Physiol 278: C914–C920, 2000. — Inositol lipid kinases generate polyphosphoinositides, important regulators of several cellular functions. We have recently cloned two distinct phosphatidylinositol (PI) 4-kinase enzymes, the 210-kDa PI4KIIIa and the 110-kDa PI4KIIIb, from bovine tissues. In the present study, the distribution of mRNAs encoding these two enzymes was analyzed by in situ hybridization histochemistry in the rat. PI4KIIIa was found predominantly expressed in the brain, with low expression in peripheral tissues. PI4KIIIb was more uniformly expressed being also present in various peripheral tissues. Within the brain, PI4KIIIb showed highest expression in the gray matter, especially in neurons of the olfactory bulb and the hippocampus, but also gave a signal in the white matter indicating its presence in glia. PI4KIIIa was highly expressed in neurons, but lacked a signal in the white matter and the choroid plexus. Both enzymes showed expression in the pigment layer and nuclear layers as well as in the ganglion cells of the retina. In a 17-day-old rat fetus, PI4KIIIb was found to be more widely distributed and PI4KIIIa was primarily expressed in neurons. These results indicate that PI4KIIIb is more widely expressed than PI4KIIIa, and that the two enzymes are probably coexpressed in many neurons. Such expression pattern and the conservation of these two proteins during evolution suggest their nonredundant functions in mammalian cells.
BIOACCUMULATORS OF HEAVY METALS IN LAKE ABHA, SAUDI ARABIA

The concentrations of four heavy metals (Pb, Cd, Zn and Cu) in the leaves of two submerged aquatic plants Potamogeton nodosus Poir. and Ceratophyllum demersum L. and the corresponding water and sediment samples were studied in Lake Abha; southwestern Saudi Arabia. Results showed that the concentrations of the four metals in the sediments, especially Cd and Pb were much higher than in the water. Based on the concentrations of the metals in Lake's water and sediment, the four metals are arranged in the following increasing order: Cd>Cu>Pb>Zn. Comparing the two plant species, Potamogeton nodosus showed higher capacity for the accumulation of Pb, Cd, and Zn. The highest concentrations of Pb, Cd, and Zn were found in the leaves of Potamogeton nodosus (26.8, 3.9 and 77.3 μg g 1 DW; respectively), while Cu in the leaves of Ceratophyllum demersum reached 25.5 μg g -1 DW. Significantly positive correlations were observed between the concentrations of Zn, Cu and Cd in the leaves of both aquatic plants and in the water, suggesting the potential use of the two plants for the monitoring of these metals. Results indicated also that the two species have high capabilities to remove heavy metals directly from the contaminated water. The potential use of these plants in wastewater treatment worths further exploration.
Determinants of extinction in a streamed trial procedure

The strength of an association between a cue and its outcome is influenced by both the probability of the outcome given the cue and the probability of the outcome in the absence of the cue. Once an association has been formed, extinction is the procedure for reducing responding indicative of the association by repeated presentation of the cue without the outcome. The present experiments tested whether cumulative frequency and/or cumulative duration of these events affects associative extinction in a streamed trial extinction procedure with human participants. Experiment 1 assessed the effects of parametric manipulations of the frequency and duration of either the cue by itself or cue–outcome co-absence. In Experiment 1, participants proved relatively insensitive to manipulation of the event’s duration. In contrast, judgements of the association by participants decreased when the frequency of cue-alone events was increased, even when the durations of those events were decreased so that cumulative exposure to the cue was equated. No effect of either the duration or the frequency of cue–outcome co-absence was observed. Experiment 2 demonstrated that the effect of cue-alone (i.e., extinction trial) frequency generalises across a wide range of parameters for initial acquisition achieved by cue–outcome pairings. Experiment 3 tested for an interaction between event duration during initial learning and event duration during extinction. Collectively, these results indicate that the cumulative frequency, and not the cumulative duration, of extinction trials as well as the duration of the cue–outcome co-absences between extinction trials control the effectiveness of an extinction procedure.