Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimativa da resistência mecânica à penetração de um latossolo vermelho sob cultura perene no norte do estado do Paraná

Uma das propriedades fisicas importantes para o manejo e estudo da qualidade fisica dos solos e sua resistencia a penetracao, uma vez que esta propriedade se apresenta relacionada a diversos atributos do solo indicadores do grau de compactacao. O objetivo deste trabalho foi estimar a resistencia mecânica do solo a penetracao de um Latossolo Vermelho eutroferrico sob cultura perene, em tres condicoes de umidade gravimetrica, a partir da densidade, umidade, teor de argila (Arg) e materia orgânica do solo. A resistencia mecânica do solo a penetracao foi avaliada mediante o uso do penetrometro de impacto, e os dados obtidos em impactos dm-1 foram convertidos em resistencia dinâmica (MPa). No momento da determinacao da resistencia mecânica do solo, foram coletadas 30 amostras por profundidade: 0-0,10; 0,1-0,3; 0,3-0,5 m, para determinacao de tres diferentes teores de umidade gravimetrica (Ug) (Ug1 0,30 kg kg-1 ), composicao granulometrica, teor de materia orgânica (MO) e densidade do solo (Ds). Foram aplicados testes de distribuicao normal para selecao das variaveis participantes dos modelos, por meio do teste W. Em seguida, foram realizadas analises de correlacao simples entre as variaveis e analise de regressao multipla por Stepwise. Para obtencao dos modelos, realizou-se uma analise com quatro variaveis independentes, representadas por: X1 = Ug, X2 = Ds, X3 = MO, X4 = Arg, e a variavel dependente (Y), caracterizada pela resistencia do solo a penetracao (RP). Apos obtencao dos modelos finais, testaram-se os efeitos de multicolinearidade por meio do VIF (Fator de Incremento de Variância), sendo os valores de VIF menores que 10 indicativos de que o efeito da multicolineridade nao influencia os resultados da regressao. Foi utilizado o nivel de significância do valor F da variavel de 15 % de probabilidade para a inclusao e exclusao de variaveis no modelo. Os resultados permitiram concluir que as equacoes que melhor estimaram a resistencia do solo a penetracao foram: para Ug 0,30 kg kg-1: RPE = 3,20 - 13,78Ug + 4,43Ds (R2 = 0,97). Em todas as situacoes estudadas, os coeficientes de variacao variaram de altos (situacao UG1) a muito altos (situacao UG2 e Ug3), caracterizando alta variabilidade espacial da RP; logo, a utilizacao dos modelos selecionados deve ser feita com cautela, pois ocorre importante dispersao de pontos estimados por meio dos modelos, em relacao aos valores medidos.
Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

Abstract Acute lung injury (ALI) or its aggravated stage acute respiratory distress syndrome (ARDS) may lead to a life-threatening form of respiratory failure, resulting in high mortality of up to 30–40% in most studies. Although there have been decades of research since ALI was first described in 1967, the clinical therapeutic alternatives for ALI are still in a state of limited availability. Supportive treatment and mechanical ventilation still have priority. Despite some preclinical studies demonstrating the benefit of pharmacological interventions, none of these has been proved completely effective to date. Recent advances in nanotechnology may shed new light on the pharmacotherapy of ALI. Nanomedicine possesses targeting and synergistic therapeutic capability, thus boosting pharmaceutical efficacy and mitigating the side effects. Currently, a variety of nanomedicine with diverse frameworks and functional groups have been elaborately developed, in accordance with their lung targeting ability and the pathophysiology of ALI. The in-depth review of the current literature reveals that liposomes, polymers, inorganic materials, cell membranes, platelets, and other nanomedicine approaches have conferred attractive therapeutic benefits for ALI treatment. In this review, we explore the recent progress in the study of the nanomedicine-based therapy of ALI, presenting various nanomedical approaches, drug choices, therapeutic strategies, and outcomes, thereby providing insight into the trends.
Measurement invariance of the distress tolerance scale among university students with and without a history of non-suicidal self-injury

Non-suicidal self-injury (NSSI) is the intentional damage to one’s body tissue in the absence of suicidal intent. NSSI primarily serves an emotion regulation function, with individuals engaging in self-injury to escape intense or unwanted emotion. Low distress tolerance has been identified as a mechanism that underlies self-injury, and is commonly assessed using the self-report Distress Tolerance Scale. There are mixed findings regarding the factor structure of the Distress Tolerance Scale, with some researchers utilising a higher-order distress tolerance score (derived from the scores on the four lower-order subscales) and other researchers using the four subscales as unique predictors of psychological outcomes. Neither of these factor structures have been assessed among individuals with a history of self-injury. Of note, an inability to tolerate distress (thought to underlie NSSI) may limit an individual’s capacity to accurately observe and report specific thoughts and emotions experienced in a state of heightened distress, which may impact the validity of scores on the Distress Tolerance Scale. Therefore, measurement invariance should be established before attributing NSSI-related differences on the scale to true differences in distress tolerance. We compared the Distress Tolerance Scale higher-order model with the lower-order four factor model among university students with and without a history of NSSI. Our results indicated that the lower-order four factor model was a significantly better fit to the data than the higher-order model. We then tested the measurement invariance of this lower-order factor model among individuals with and without a history of NSSI, and established configural and full metric invariance, followed by partial scalar and full residual error invariance. These results suggest the four subscales of the Distress Tolerance Scale can be used to confidently discern NSSI-related differences in distress tolerance.
A Case of Solid Variant of Adenoid Cystic Carcinoma from Trachea: A Case Report and Review of Literature

Introduction Primary tracheal adenoid cystic carcinoma (ACC) is a rare and heterogeneous group of neoplasms arising from the respiratory tract. The solid variant of ACC is a histologically distinct subtype with an unfavorable clinical course. We report on a case of tracheal ACC with immunohistochemical and molecular analysis together with a review of the literature. Case Report We observed a case in which a 31-year-old male presented with a neoplasm bulging into the lumen and caused symptoms of tracheal obstruction and even hemoptysis. Cytological smears of an endobronchial fine needle aspiration revealed aggregates of basaloid cells with small to medium size, scant cytoplasm, and evenly hyperchromatic nuclei. Histologically, the tumor is characterized by a predominant compact sheet-like and nested pattern of rounded basaloid cells. Immunohistochemically, the tumor was diffusely positive for CK and CD117. CK7 and CK5/6 were focally positive in the genuine glandular structures. P63 was completely negative in the majority of neoplastic cells. Fluorescence in situ hybridization analysis revealed MYB gene rearrangement. Conclusion The solid variant of ACC from trachea is rare and hence poses diagnostic difficulty. Computed tomography (CT) scan and bronchoscopy help assess the extent of the disease. Histological features combined with immunophenotypic and molecular analysis aid in distinguishing this uncommon type from other round cell neoplasms. The accurate diagnosis can help expedite treatment of this highly aggressive tumor.
To Flip or Not to Flip: Learning Style Preferences among Millennial Physician Assistant Students

Introduction: Presenting material in a manner that is most palatable to students is important to improve the learning process. We evaluated the efficacy of different teaching styles including the flipped classroom and assessed the learning style preferences of a cohort of medical learners in a preclinical obstetrics and gynecology course. Methods: We conducted three teaching sessions with 35 physician assistant students. A different teaching style was implemented for each session including a traditional lecture with interactive learning technology augmentation, a flipped classroom, and a hybrid approach incorporating lecture and group work. Students were surveyed using a Likert scale regarding the efficacy of the format, clinical relevance of the material, and their learning preference for future sessions. Results: Students rated the traditional approach as the most effective, most relevant, and most preferred method. Students preferred the flipped classroom least, but they rated it as slightly more effective and relevant than the hybrid approach. Conclusion: The teaching style of various coursework including the preclinical obstetrics and gynecology curriculum may not need to be altered for millennial learners. This study showed the flipped classroom was the least favored teaching style and that there was a marked preference by students for a more traditional didactic lecture.
Organ-Specific Tumor Response to Pembrolizumab in Advanced Urothelial Carcinoma After Platinum-Based Chemotherapy

Background To evaluate the organ-specific therapeutic effect of pembrolizumab after the failure of platinum-based chemotherapy for advanced urothelial carcinoma (UC). Materials and Methods Patients with advanced UC who received pembrolizumab after the failure of platinum-based chemotherapy and who had measurable disease were retrospectively analyzed. The objective response rate (ORR) and organ-specific response rate (OSRR) were evaluated according to Response Evaluation Criteria in Solid Tumors, version 1.1. Results We analyzed 69 patients (male, n=51; median age, 71 years) with 226 metastases. The ORR was 23.2%. In total, 32, 31, 16, 14, 13 and 7 patients had measurable lung (OSSR 31.3%), lymph node (OSSR 29.0%), local recurrence (OSSR 12.5%), primary tumor organ (OSSR 7.1%), liver (OSSR 23.1%) and bone (OSSR 28.6%) disease, respectively. The median overall survival (OS) for pembrolizumab was 10.9 months (95% confidence interval, 5.9‑13.7 months). Regarding organ-specific OS, a Log rank test significant differences in OS were confirmed between patients with and without primary tumor organ disease (p=0.046) and liver metastasis (p<0.001). Conclusion Metastases and primary tumor organ disease showed different tumor responses to pembrolizumab. The most prominent tumor response was found in lung metastasis and the least response was found in primary organ sites. The mechanisms of these different responses were unclear and there does not appear to be a constant trend between tumor shrinkage and OS in tumor sites. Further studies are needed.
Psychometric Properties of Two Implicit Associations Tests measuring Adult Attachment

Adult attachment style has consequences for mental health, interpersonal functioning and emotion regulation. This occurs partly deliberately, also referred to as explicit, and partly on an automatic level outside of conscious awareness, also referred to as implicit. Whereas explicit adult attachment can be assessed with self-report instruments, measurement of implicit adult attachment requires indirect methods. This paper describes the psychometric properties of two Implicit Association Tests measuring general adult attachment in a population sample. The study evaluated the reliability and the validity of the Avoidant Attachment IAT (ANX-IAT) and the Anxious Attachment IAT (AVOID-IAT). Validity was evaluated against self-report measures of adult attachment style (RQ), psychopathology (SQ-48), and well-being (MHC-SF). The split-half reliabilities of both IATs were good; the test-retest reliability of the ANX-IAT was adequate; however the AVOID-IAT had low test-retest reliability. Both IATs did not explain variance in psychopathology additional to explicit measures. The AVOID-IAT showed added value over explicit measurement of avoidant attachment in explaining variance in well-being, particularly regarding emotional and psychological well-being. The ANX-IAT did not explain variance in any measure of well-being additional to the explicit measure of anxious attachment. Our findings provide a basis from which more valid IATs measuring general adult attachment can be developed. Furthermore, they suggest that implicit avoidant attachment might be related to well-being, particularly emotional and psychological well-being. However, further research is needed to investigate the role of implicit general adult attachment in mental health and to optimize the two IATs in terms of validity before clinical use is recommended.
Quantification of gray mold infection in lettuce using a bispectral imaging system under laboratory conditions

Abstract Gray mold disease caused by the fungus Botrytis cinerea damages many crop hosts worldwide and is responsible for heavy economic losses. Early diagnosis and detection of the disease would allow for more effective crop management practices to prevent outbreaks in field or greenhouse settings. Furthermore, having a simple, non‐invasive way to quantify the extent of gray mold disease is important for plant pathologists interested in measuring infection rates. In this paper, we design and build a bispectral imaging system for discriminating between leaf regions infected with gray mold and those that remain unharmed on a lettuce (Lactuca spp.) host. First, we describe a method to select two optimal (high contrast) spectral bands from continuous hyperspectral imagery (450–800 nm). We then explain the process of building a system based on these two spectral bands, located at 540 and 670 nm. The resultant system uses two cameras, with a narrow band‐pass spectral filter mounted on each, to measure the bispectral reflectance of a lettuce leaf. The two resulting images are combined using a normalized difference calculation that produces a single image with high contrast between the leaves’ infected and healthy regions. A classifier was then created based on the thresholding of single pixel values. We demonstrate that this simple classification produces a true‐positive rate of 95.25% with a false‐positive rate of 9.316% in laboratory conditions.
Assessing the thermo-tolerance potentials of five commercial layer chicken genotypes under long-term heat stress environment as measured by their performance traits

This study was conducted to test the thermo-tolerance ability of five commercial chicken genotypes (Lohmann Brown, LB; Lohmann White, LW; New Hampshire, NH; White Leghorn selected for low feed expenditure, WL-FE and White Leghorn with sex-linked dwarf gene, WL-dw) under long-term heat exposure. Two-hundred forty female chickens were assigned to a completely randomized design in a 5 × 2 factorial arrangements (five genetic groups and two ambient temperatures [thermo-neutral, 18–20 °C; heat stress, 30–32 °C]). Individual eggs were collected on daily basis while egg weight and feed intake were determined on individual and group basis at 28-days intervals, respectively. Shell quality traits were determined at 25, 40 and 56 weeks age. No Genotype × ambient temperature interactions were found except for body weight and egg deformation. Chickens at thermo-neutral temperature produced significantly heavier eggs than those of heat-exposed (60 g vs. 54 g). Hen-housed egg production of chickens in thermo-neutral temperature was significantly higher than those of heat-stressed (76.8 % vs. 66.2 %). Daily egg mass production at thermo-neutral and heat stressed chickens was 46 g and 35.8 g, respectively. Feed consumption in heat-stressed and thermo-neutral chickens was 109 and 80.8 g, respectively. Shell thickness, breaking strength and Haugh unit values were significantly reduced in heat-stressed chickens. Among heat-exposed chickens, the NH had the highest body weight while the LW produced 10 % more eggs than the group average. The heat-induced effect on shell quality traits was lowest in LW chickens. The results indicated that the magnitude of heat stress was breed dependent in which the LB showed poor adaptability to heat stress while both NH and LW genotypes demonstrated better thermo-tolerance ability.
A Difference Between Bedtime and Pre-Breakfast Plasma Glucose Levels Indicates the Need for Prandial Insulin in Basal Insulin-Treated Type 2 Diabetic Patients with Normal Fasting Glucose

Aim In the present analysis, we characterised the efficacy and safety of adding a single daily injection of insulin glulisine to optimised basal-supported oral therapy (BOT) in patients with a high BeAM value, defined as a more than 50 mg/dl difference between bedtime and pre-breakfast blood glucose. Methods The BeAM value was retrospectively calculated for patients pooled from two clinical trials that supplemented BOT with glulisine. Data regarding changes in HbA1c, fasting plasma glucose (FPG), and postprandial glucose (PPG) levels from observation periods of 3 to 6 months were assessed. Results Out of 358 patients that received BOT/glulisine, 182 had a high BeAM value. Patients with a high BeAM value were older and had a longer diabetes duration than patients with a medium BeAM value. Significant reductions in HbA1c (7.5% to 7.2% [59 to 55 mmol/mol], p<0.0001) and PPG (202 to 143 mg/dl, p<0.0001) levels were documented. The proportion of patients with a high BeAM value achieving an HbA1c <7% [53 mmol/mol], alone or in combination with no hypoglycaemia, was lower than that of patients with a medium BeAM value. Conclusion The analysis indicates that the supplementation of BOT with a single daily injection of prandial insulin is safe and effective for reducing HbA1c and PPG levels in patients with a high BeAM value (more than 50 mg/dl). However, patients with a medium BeAM value also responded well, which suggests that they should also be considered candidates for this change in therapy.
Association Between Airflow Limitation and Carotid Intima-Media Thickness in the Japanese Population

Purpose This study aimed to reveal the association between airflow limitation (AL) and carotid intima-media thickness (IMT) according to smoking status in Japan. Subjects and Methods This cross-sectional study was performed in 2809 subjects, who underwent a comprehensive health examination with pulmonary function tests and carotid ultrasonographic measurement. AL was defined as forced expiratory volume in 1 s/forced vital capacity of <0.7. The subjects were divided into the following four groups: never smokers without AL, never smokers with AL, former/current smokers without AL, and former/current smokers with AL. Mean IMT, the maximum measurable IMT value in the left and right common carotid arteries (IMT-C max), and mean IMT-C max were measured by carotid ultrasonography. The carotid wall thickness as defined as follows: IMT ≥ 1.1 mm (IMT1.1), IMT-C max ≥ 1.2 mm (IMTc1.2), and IMT-C max > 1.5 mm (IMTc1.5), based on each measured region. The association between AL and the carotid wall thickness according to smoking status was assessed by logistic regression analysis. Results The mean carotid IMT and mean IMT-C max were significantly higher in never smokers with AL and former/current smokers with or without AL than in never smokers without AL. In logistic regression models adjusted for sex, age, body mass index, hypertension, dyslipidemia, hyperglycemia, physical activity, and alcohol consumption, the risk of carotid wall thickness (IMT1.1 [odds ratio {OR}: 1.55; 95% confidence interval {CI}: 1.07–2.24]; IMTc1.2 [OR: 1.52; 95% CI: 1.03–2.24]; IMTc1.5 [OR: 1.99; 95% CI: 1.15–3.46]) were significantly higher in former/current smokers with AL than in never smokers without AL. Conclusion The present results suggest that greater IMT and risk of carotid wall thickness were associated with AL and smoking experience.
Associations with monetary values do not influence access to awareness for faces

Human faces can convey socially relevant information in various ways. Since the early detection of such information is crucial in social contexts, socially meaningful information might also have privileged access to awareness. This is indeed suggested by previous research using faces with emotional expressions. However, the social relevance of emotional faces is confounded with their physical stimulus characteristics. Here, we sought to overcome this problem by manipulating the relevance of face stimuli through classical conditioning: Participants had to learn the association between different face exemplars and high or low amounts of positive and negative monetary outcomes. Before and after the conditioning procedure, the time these faces needed to enter awareness was probed using continuous flash suppression, a variant of binocular rivalry. While participants successfully learned the association between the face stimuli and the respective monetary outcomes, faces with a high monetary value did not enter visual awareness faster than faces with a low monetary value after conditioning, neither for rewarding nor for aversive outcomes. Our results tentatively suggest that behaviorally relevant faces do not have privileged access to awareness when the assessment of the faces’ relevance is dependent on the processing of face identity, as this requires complex stimulus processing that is likely limited at pre-conscious stages.
Comparison Between Pioglitazone/Metformin Combination Therapy and Sitagliptin/Metformin Combination Therapy on the Efficacy in Chinese Type 2 Diabetic Adults Insufficiently Controlled with Metformin: Study Protocol of an Open-Label, Multicenter, Non-Inferiority Parallel-Group Randomized Controlled T

Introduction The prevalence of type 2 diabetes (T2D) has risen substantially in China, where its pathophysiology is primarily characterized by insulin resistance (IR). Alleviating IR may help with the management of T2D in the Chinese population. Pioglitazone and sitagliptin are two hypoglycemic medications with different pharmacological actions, both of which are optimal choices for use in combination with metformin. Previous studies have yielded mixed findings regarding the differences in hypoglycemic effects between the two agents. Though pioglitazone is associated with weight gain, both drugs have been shown to decrease visceral adipose tissue (VAT) and improve IR in individuals with T2D. There is a lack of direct comparisons between pioglitazone and sitagliptin among Chinese individuals with T2D. Therefore, this paper describes a protocol for a randomized controlled trial (RCT) that investigates the differences in hypoglycemic efficacy, IR improvement, and safety profiles between these drugs. Methods and Analysis This is a 24-week, open-label, multicenter, non-inferiority parallel-group RCT with a 1:1 allocation ratio. It compares pioglitazone/metformin (15 mg/500 mg) combination therapy with sitagliptin/metformin (50 mg/500 mg) combination therapy in Chinese adults with T2D insufficiently controlled with metformin. The primary outcomes are HbA1c reduction, insulin level increase, and IR index change. The secondary outcomes are body weight and abdominal VAT decreases, lipid profiles, and inflammatory indicators. Tolerability and safety data will also be collected. Conclusion It is believed that the direct comparisons of the hypoglycemic effects, VAT reductions, and safety profiles between pioglitazone and sitagliptin will help to optimize treatments for Chinese adults with T2D who are primarily characterized by IR. Trial Registration Number Chinese Clinical Trial Registry (ChiCTR1900021861).