Miracle-dz/UniFAR-FTUs huggingface dataset:
Single‐cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer

B cells constitute a major component of infiltrating immune cells in colorectal cancer (CRC). However, the characteristics of B cells and their clinical significance remain unclear. In this study, using single‐cell RNA sequencing and multicolour immunofluorescence staining experiments, we identified five distinct subtypes of B cells with their marker genes, distribution patterns and functional properties in the CRC tumour microenvironment. Meanwhile, we found a higher proportion of IgG plasma cells in tumour sites than that in adjacent normal mucosal tissues. In addition, the CXCL13‐producing CD8+ T cells in the tumour tissues could promote the formation of tertiary lymphoid structure (TLS) B cells, and the CCL28–CCR10 axis is pivotal for IgG plasma cell migration from the periphery of TLSs to the tumour stroma. Finally, we identified four distinct colon immune classes (CICs: A–D) and found that CD20+ B cells within TLSs were enriched in one immune‐inflamed or hot tumour group (CIC D). This B cell‐rich group, which was characterized by strong antigen presentation, IgG plasma cells accumulation, microsatellite instability‐high (MSI‐H) and high tumour mutation burden (TMB‐H), as well as immunosuppressive property in particular, might become a potential predictive biomarker for future immunotherapy. Additionally, in an immunotherapy cohort, patients with the enrichment of B cells and TLSs were demonstrated to obtain significant therapeutic advantages. Together, our findings provide the detailed landscape of infiltrating B cells and their potential clinical significance in CRC.
Reversible Gynecomastia in HIV-Infected Man Treated With Triple Antiretroviral Therapy Containing Efavirenz: A Case Report

Gynecomastia is benign hypertrophy of male breast glandular tissue, either unilateral or bilateral, secondary to increased estrogen/testosterone ratio (elevated estrogen level, decreased testosterone levels, or both). The condition can be related to a medical disease or caused by some drugs. Since the introduction of triple antiretroviral therapy (TAT), we have seen an improvement in the prognosis of human immunodeficiency virus (HIV) infection. Here we report the case of a 53-year-old man receiving follow-up care in Internal Medicine for HIV infection receiving TAT (tenofovir/efavirenz/emtricitabine). After one year, the patient presented in the Department of Endocrinology, Diabetology, Metabolic Diseases, and Nutrition of Hassan II University Hospital Center, Fez, with bilateral gynecomastia. Hormonal exploration did not reveal any abnormality, so the gynecomastia was attributed to efavirenz use. The regimen was replaced by tenofovir, lamivudine, and dolutegravir. The gynecomastia was resolved within two months of discontinuing efavirenz. In summary, we think that secondary gynecomastia should be suspected and screened in HIV patients receiving efavirenz-containing regimens.
The use of the term ‘occupational profile’ in occupational therapy and occupational science literature: A scoping review

Introduction The term ‘occupational profile’ is widely used within the occupational therapy profession; however, its use and application appear inconsistent in the literature. Understanding how occupational profile is described in existing literature can reduce ambiguity and strengthen consistent use of terminology across practice and research. Methods A scoping review was conducted to examine how occupational profile has been described in occupational therapy and occupational science literature. Results Seventy-six journal papers were included. A lack of consistent definitions, conceptualisation and measurements was identified. Key concepts relating to the conceptualisation of occupational profile included occupational history, motivation and performance. Only one measurement was used consistently with paediatric clients to identify individuals’ occupational profiles. Occupational profiles of populations and communities were not identified. Conclusion The lack of consistency in definitions, conceptualisation and measurement of the term ‘occupational profile’ presents significant issues for occupational therapy practice, including an inability to compare populations. Researchers should articulate their conceptualisation of occupational profile in the absence of a universally agreed-upon definition. More comprehensive measures seeking to explore the occupational profile of a variety of clients need to be developed. Occupational profiles of communities and populations should be explored to understand occupational patterns and identify potential occupational issues.
CPP-ACP complex as a solution to the problem of complications after teeth bleaching - a literature review

Introductions and purpose: Teeth bleaching is an increasingly popular procedure that comes with its specific set of complications including damaged enamel, dentin hypersensitivity, and increased vulnerability to bacterial colonization. CPP-ACP complex possesses remineralizing and bacteriostatic properties as well as the ability to abolish dentin hypersensitivity. The aim of this study is to systematise the state of current knowledge on the use of casein phosphopeptide with amorphous calcium phosphate in combating complications after tooth bleaching. Description of the state of knowledge: The CPP-ACP complex used alone or in a protocol with a bleaching agent, in a way that is comparable to other products, abolishes post-operative dentin hypersensitivity by blocking the flow of dentino-pulpal tubular fluid. It restores the morphological properties of the tooth, by increasing the hardness of the bleached enamel, more effectively than fluoride agents. Casein phosphopeptide with amorphous calcium phosphate limits the penetration of the bleaching agent into the tooth chamber, thereby preventing the development of pulp inflammation. Moreover, because of its buffering properties, it prevents the development of caries on surfaces weakened by the bleaching process.
EFL Teachers’ Perceptions of the Implementation of Active Learning in Reading Classroom

In recent years, scholars and educators of the English language have shown a lot of interest in the active learning approach. Although a few studies have been conducted on teachers' perceptions and practices of active learning in classrooms, few studies have been conducted in Vietnamese contexts on teachers' perceptions and practices of the function of active learning in reading classrooms. Due to that gap, the current study was conducted to investigate teachers' perceptions regarding active learning techniques used in reading classrooms and the role active learning plays in reading instructions. The paper conducted a descriptive study in order to identify the active learning approaches employed by EFL teachers in reading classrooms at private language centers and investigates their perspectives on the role of active learning in reading instruction. The questionnaire and semi-structured interviews were used to collect data from two sources. The participants were twenty-six teachers of English as a foreign language (EFL) from the province of Vinh Long. The result reveals that the participants had a favorable view of the role of active learning. In particular, they felt that active learning allows students to improve their critical thinking and reading comprehension, as well as teamwork, interpersonal skills, and problem-solving abilities. These findings have a number of educational implications.
National Hypertension Guidelines: A Review of the India Hypertension Control Initiative (IHCI) and Future Prospects

Hypertension is a silent killer; however, the treatment of hypertension is simple, effective, readily available, and needs to be continued lifelong. It is a significant health problem that is included under the umbrella of non-communicable disease conditions and has a strong alliance with cardiovascular morbidity and mortality. The India Hypertension Control Initiative (IHCI) is an extensive program in India that involves the Indian Council of Medical Research, the Ministry of Health and Family Welfare (Government of India), the state governments of India, and World Health Organization Country Office for India (WHO-India). The IHCI is a multi-partner initiative carried forward systemically across various states. The states are categorized into Grade I and Grade II. There is the involvement of specialized teams of cardiovascular experts and health officials to insure precise execution and seamless healthcare service. The implementation of the free and easy-to-use mobile application and software, Simple (Resolve to Save Lives, New York City, United States), in the analysis and storage of data, is a novel step taken to insure safe record keeping and follow-ups. Emphasis is on the adoption of demography-specific interventional methods and drugs, and proper acquisition and storage of these drugs is the key step. Treatment modalities involve the adoption of medicines and lifestyle modifications as a combined recipe. Advancements have been made in the area of drug development like gene therapies but they seem to show low success rates at the given moment. Adoption of lifestyle modifications along with medications is the gold standard treatment option. This review article aims to shed light on the current status of IHCI, its milestones, and the future of the initiative in India.
Clinical Characteristics and Outcome Related to Blood Eosinophilic Chronic Obstructive Pulmonary Disease (COPD) Patients

Introduction The term chronic obstructive pulmonary disease (COPD) refers to a range of illnesses that impair breathing and airflow. Clinical history of COPD is further impacted by frequent exacerbations known as acute exacerbation COPD in which these specific symptoms worsen contributing to emergency room (ER) visits and hospitalization. Blood eosinophils are a crucial indicator of therapy effectiveness and exacerbation rate. The role of blood eosinophils as a biomarker for treatment, response, exacerbation risk, inflammation, and other symptoms in COPD patients is implemented by the Global Initiative Obstructive Lung Disease (GOLD) as guidelines. Objective To determine the clinical characteristics and outcomes related specifically to eosinophilic COPD Patients. Methodology This is a retrospective single-center study of all AECOPD presented at ET between 2018 to 2019. A total of 120 patients were included. Patients were divided into two groups depending on blood eosinophil count: high (>300cells/µL) and low (<300cell/µL). Finally, Binary logistics regression was performed to determine correlations between clinical characteristics and eosinophil count levels. Results In the high eosinophil patients’ group: none of the independent variables were statistically significant. However, in the low eosinophil patients’ group: ER visits, lung disease, and symptomatic exacerbation made a statically significant contribution to the model (p-value of .008, .01, .001) respectively. Conclusion and recommendation The higher eosinophil levels showed better clinical outcomes compared to lower eosinophil levels. Increasing the level of symptomatic AECOPD episodes in low eosinophil levels may be linked to the onset of bacterial infection and airway inflammation. The study further recommends a prospective cross-sectional multi-center study which includes a follow-up of the patients to assess the number of exacerbations after initial treatment
Hole mobility in thermally evaporated pentacene: Morphological and directional dependence

Pentacene has been extensively studied as an active material for organic field-effect transistors as it shows very good charge carrier mobility along its preferred transport direction. In this contribution, we investigate the hole transport in pentacene thin films by measurement in conventional lateral organic field-effect transistors (OFETs), which yields the hole mobility along the a-b plane of pentacene, and by the recently published potential mapping (POEM) approach, which allows for direct extraction of the charge carrier mobility perpendicular to the substrate, in this case perpendicular to the a-b plane, without the assumption of a specific transport model. While the mobility along the a-b plane—determined from OFET measurements—is found to be in the region of 0.45 cm2/Vs, transport perpendicular to this plane shows an average mobility at least one order of magnitude lower. Investigating also how these effective mobility values depend on the deposition rate of the pentacene films, we find that the .
Exploring the tensions science teachers navigate as they enact their visions for science teaching: what their feedback can tell us

ABSTRACT This paper reports on inservice science teachers’ collaborative feedback to each other on videos of their classroom teaching during debrief sessions. We aimed to understand how the teachers’ feedback reflected their vision for science education and how they collaboratively identified and discussed the misalignments between their vision and actual classroom practices. Ten videos of debrief sessions involving 17 K-12 science teachers participating in a teacher leadership professional development program were analysed. The feedback captured the teachers’ reflections as they collaboratively identified issues that were important to them and attempted to resolve them together. Our initial analysis of the data led us to frame our study within the literature on critical reflection, democratic practices, and student agency in science education. The teachers had a deep awareness of the need for democratic practices and shared power in their classrooms. Their feedback, however, revealed the tensions that arose as they discussed enactments of each of these tenets in the classroom. This study contributes to the literature on feedback given among inservice science teachers and proposes a professional development model that supports teachers’ professional learning in a social and democratic setting.
Multiplicative reduction and the cyclotomic main conjecture for GL2

We show that the cyclotomic Iwasawa--Greenberg Main Conjecture holds for a large class of modular forms with multiplicative reduction at $p$, extending previous results for the good ordinary case. In fact, the multiplicative case is deduced from the good case through the use of Hida families and a simple Fitting ideal argument.
Effects of Zakat and Government Debt on the Indonesian Economy

In order to increase the country's economic growth, a stimulus is needed that can be used to detect whether there is an effect or not on changes in economic growth. As in the concept of modern economic growth which involves the role of household consumption and government expenditure. This thesis also uses the variable of state debt as a form of economic stimulus so that it will increase further and the distribution of zakat is also used as a driving factor for public consumption. This study aims to analyze whether there is an influence of zakat, consumption, state debt and government spending on economic growth in Indonesia for the period 2018-2020. The type of data used is secondary data obtained from BPS, BI, and the Ministry of Finance through published agency reports that were analyzed using multiple linear regression with the help of the E-Views 10 Program. The results of this study are the variables of zakat, consumption, state debt and government spending simultaneously have an effect on economic growth in Indonesia for the 2018-2020 period. The basic formulation of the philosophy of Islamic economic development includes the first Tawhid rububiyah, which states the basics of Allah's law to further regulate the development model based on Islam. Second, justice, namely development that is not lame (gaps), but equitable economic development (growth with equity). The third is the Khilafah, which states that humans are Allah's representatives on earth to prosper the earth and are responsible to Allah regarding the management of the resources entrusted to them. and lastly, Tazkiyah, which is to purify humans in their relationship with Allah, each other and the natural environment, society and country. Keyword : National Debt, Economy, Zakat
Change and Continuity in Citizens’ Evaluations of Supreme Court Nominees

In the 1980s and 1990s, supporters of Supreme Court nominees tended to characterize their views in non-ideological terms while opponents relied more on ideological justifications. Since then, the judicial appointment process has been increasingly entangled with partisan conflict. Given the heightened focus on nominees’ ideological preferences, we expect that citizens are now more likely to rely on political over apolitical justifications, even if they support the nominee. We use data from a telephone survey in 2017 after the nomination of Judge Neil Gorsuch to test this proposition. We find that contemporary citizens rely more frequently on political justifications for their support of nominees than then they did in the Reagan-Bush era. Opponents remain more likely to invoke political orientations, but the disparity has declined. The findings reveal both change and continuity in citizens’ evaluations of Supreme Court nominees.
Modeling Global Carbon Costs of Plant Nitrogen and Phosphorus Acquisition

Most Earth system models (ESMs) do not explicitly represent the carbon (C) costs of plant nutrient acquisition, which leads to uncertainty in predictions of the current and future constraints to the land C sink. We integrate a plant productivity‐optimizing nitrogen (N) and phosphorus (P) acquisition model (fixation & uptake of nutrients, FUN) into the energy exascale Earth system (E3SM) land model (ELM). Global plant N and P uptake are dynamically simulated by ELM‐FUN based on the C costs of nutrient acquisition from mycorrhizae, direct root uptake, retranslocation from senescing leaves, and biological N fixation. We benchmarked ELM‐FUN with three classes of products: ILAMB, a remotely sensed nutrient limitation product, and CMIP6 models; we found significant improvements in C cycle variables, although the lack of more observed nutrient data prevents a comprehensive level of benchmarking. Overall, we found N and P co‐limitation for 80% of land area, with the remaining 20% being either predominantly N or P limited. Globally, the new model predicts that plants invested 4.1 Pg C yr−1 to acquire 841.8 Tg N yr−1 and 48.1 Tg P yr−1 (1994–2005), leading to significant downregulation of global net primary production (NPP). Global NPP is reduced by 20% with C costs of N and 50% with C costs of NP. Modeled and observed nutrient limitation agreement increases when N and P are considered together (r2 from 0.73 to 0.83).
Exploring the meaningful qualities of transactions in virtual environments for massively multiplayer online role-playing gamers

ABSTRACT To date, most research on massively multiplayer online role-playing games (MMORPGs) has focused on the effects playing MMORPGs have on players’ health and wellness. The virtual environment of MMORPGs has yet to be explored as a space where meaningful occupations occur. This qualitative descriptive study examined the virtual environment using a transactional perspective to describe the qualities of gaming to which MMORPG players ascribe meaning. Participants included six MMORPG players with experience playing World of Warcraft, Runescape, or Guild Wars 2. Data were gathered using interviews, participant observation, and a focus group, and analyzed using thematic analysis. Three themes were generated: Creating collective occupational experiences, Facilitating personally transformative occupational experiences, and Unlocking immersive virtual environments. Participants described collective occupational experiences of gaming as creating a sense of community and belonging. Transactions in the virtual environment facilitated a transformative occupational experience to foster identity development and personal growth. The virtual environment was described as meaningful by unlocking an immersive experience through the aesthetics of the environment and engagement with in-game occupations. These findings provide occupational scientists with an increased understanding of the qualities of transactions within games that are meaningful for MMORPG players.
Sequential monitoring of high‐dimensional time series

In the paper we derive new types of multivariate exponentially weighted moving average (EWMA) control charts which are based on the Euclidean distance and on the distance defined by using the inverse of the diagonal matrix consisting of the variances. The design of the proposed control schemes does not involve the computation of the inverse covariance matrix and, thus, it can be used in the high‐dimensional setting. The distributional properties of the control statistics are obtained and are used in the determination of the new control procedures. Within an extensive simulation study, the new approaches are compared with the multivariate EWMA control charts which are based on the Mahalanobis distance.
The APM galaxy survey. I - APM measurements and star-galaxy separation

Un survey de 20 millions d'images plus brillantes que b J = 22 a ete construit dans une aire de 4300 degres carres couvrant la calotte galactique sud. Le survey est base sur 185 plaques contigues a latitude galactique elevee du survey J UKSTU qui ont ete digitalisees en utilisant la machine APM (Automatic Plate Measuring) du SERC a Cambridge. L'analyse des images et la parametrisation utilisee sont decrites. La precision des mesures resultantes est presentee. Les profils des brillances de surface des images sont utilises pour distinguer les galaxies des etoiles.
The impact of knowledge management system quality on the usage continuity and recommendation intention

This study aimed to examine the influence of knowledge management system (KMS) quality on users’ continuance intention. The research model was developed by integrating the concept of DeLone and McLean’s information systems (IS) success model with the expectation confirmation model. To examine the developed model, a survey was conducted with 131 respondents from three companies that had implemented a KMS. The data were analyzed using the partial least square (PLS) method. The study demonstrated that both system quality and information/knowledge quality influence all the factors that drive the continuance intention regarding KMS usage, namely perceived usefulness, satisfaction, and trust. Moreover, satisfaction proved to have an impact on users’ recommendation intention concerning the KMS. Therefore, companies should improve the KMS quality in order to drive employees to continuously use the KMS and recommend it to others. https://doi.org/10.34105/j.kmel. 2017.09. 012
Unit Roots and Identification in Autoregressive Panel Data Models: A Comparison of Alternative Tests

We compare the finite sample behaviour of various unit root tests for micro panels where the number of individuals is typically large, but the number of time periods is often very small. As in this case some econometric estimators do not identify the parameters of interest when the processes are random walks, it is important to test for unit roots/identification. We find that a t-test based on OLS estimation results provides a simple robust test with high power for cases when the variance of the unobserved heterogeneity is relatively small. Its behaviour is similar to the underidentification test as proposed by Arellano, Hansen and Sentana (1999) for the GMM estimator on a first-differenced model.