Miracle-dz/UniFAR-FTUs huggingface dataset:
A Data-driven Approach to Harvesting Latent Reduced Models to Precondition Lossy Compression for Scientific Data

In this paper, we propose and evaluate the idea that data need to be preconditioned prior to compression, such that they can better match the design philosophies of lossy compressors for HPC scientific data. In particular, we aim to identify a reduced model that can be utilized to transform the original data into a more compressible form. We begin with two PDE applications as a proof of concept, in which we demonstrate that a reduced model can indeed reside in the full model output, and can be utilized to improve compression ratios. A mathematical proof is also presented to show how the compression ratio is improved by the reduced model. We further explore more general dimension reduction techniques to extract the reduced model, including principal component analysis, singular value decomposition, and discrete wavelet transform. After preconditioning, the reduced model in conjunction with difference between the reduced model and full model is stored, which results in higher compression ratios. We evaluate the reduced models on ten scientific datasets, and the results show the effectiveness of our approaches. Given that there is no single method that consistently achieves the best performance, we further propose a selection strategy that guides users to select the best reduced model prior to data reduction.
“Do You Really Want to be Disappointed?”: Adoptees’ Expectations and Violations During Birth Family Contact

ABSTRACT The current study used an Expectancy Violations Theory (EVT) framework to explore the expectations that adult adoptees have as they begin to make contact with birth family members. Thirty-two semi-structured interviews with adoptees revealed expectations for birth family contact, violations that occurred during contact, and effects of those violations. Largely, expectations were negative, as adoptees were concerned that contact would (a) cause problems for the birth family member, (b) result in a second rejection, or (c) reveal negative information about the birth family member. Adoptees experienced both positive and negative violations when they made contact, resulting in feelings of uncertainty. These results shed light on the complicated process of making birth family contact.
Rizatriptan-Loaded Oral Fast Dissolving Films: Design and Characterizations

Rizatriptan (RZT) is an efficient anti-migraine drug which belongs to the class of selective 5 HT (1B/1D) serotonin receptor agonists. Nevertheless, RZT elicits several adverse effects and RZT nasal sprays have a limited half-life, requiring repeated doses that could cause patient noncompliance or harm to the nasopharynx and cilia. The current research aimed to develop orally disintegrating films (ODFs) of RZT employing maltodextrin (MTX) and pullulan (PUL) as film-forming polymers, as well as propylene glycol (PG) as a plasticizer. The ODFs were prepared by solvent casting method (SCM). The technique was optimized using Box–Behnken design (BBD), contemplating the ratios of PUL: MTX and different levels of PG (%) as factor variables. The influence of these factors was systematically analyzed on the selected dependent variables, including film thickness, disintegration time (D-time), folding endurance (FE), tensile strength (TS), percent elongation (%E), moisture content (%), and water uptake (%). In addition, the surface morphology, solid state analysis, drug content uniformity (%), drug release (%), and pH of the RZT-ODFs were also studied. The results demonstrated a satisfactory stable RZT-ODFs formulation that exhibited surface homogeneity and amorphous RZT in films with no discernible interactions between the model drug and polymeric materials. The optimized film showed a rapid D-time of 16 s and remarkable mechanical features. The in vitro dissolution kinetics showed that 100% RZT was released from optimized film compared to 61% RZT released from conventional RZT formulation in the initial 5 min. An animal pharmacokinetic (PK) investigation revealed that RZT-ODFs had a shorter time to achieve peak plasma concentration (Tmax), a higher maximum plasma concentration (Cmax), and area under the curve (AUC0−t) than traditional oral mini capsules. These findings proposed a progressive approach for developing anti-migraine drugs that could be useful in reducing the complications of dysphagia in geriatric and pediatric sufferers.
Identifying the Characteristics of Pregnant Women with Inflammation/Infection in Indonesia

Infection in pregnant women is common and one of the highest causes of death in Indonesia. Reducing infection conditions through early infection prevention needs to be done, one of which is by knowing the characteristics that contribute to the incidence of infection in pregnant women in Indonesia. This study used the Classification and Regression Tree (CART) method to determine the pregnant women with infections and not infections characteristics and classify them. The results of the CART analysis found that seven variables contributed to separating infected and not-infected status in pregnant women, they are nutritional status based on Body Mass Index (BMI), history of anemia, pregnancy distance, Chronic Energy Deficiency (CED) status, ages, socioeconomic and gestational age. Characteristics of the highest incidence of infection, namely 79%, occurred in the group of pregnant women with overweight – obese (BMI>25.0), anemia and pregnancy distance <3 years. The classification analysis of the CART method in this study resulted in the accuracy of identification performance which was still not good, with an accuracy value of 52.78%. It is necessary analysis with other classification methods such as the Chi-square Automatic Interaction Detection (CHAID) in the future.
Principals’ leadership styles: Critical components to the security management in selected secondary schools in Mandera county, Kenya

Introduction: Leadership styles of school principals plays a significant role in making the school a safe haven for students. This is because principals interact with the school community more often, and hence understand the school environment better. Purpose: Determine the critical leadership style in the security management in Mandera County, Kenya Methodology: The correlational study design was used as the framework that anchored the study. The survey targeted a population of 424 teachers, 46 principals, 460 BOM members and 13,387 students in Mandera County which makes a total population of 14,317. The sample size was 201 teachers, 40 principals, 210 BOM members and 373 students and thus narrowing the sample size to 824 respondents. The respondents were stratified, proportionately and randomly sampled. Questionnaires for teachers, semi- structured interview guides for principals and BOM members, and focus groups were adopted as instruments of collecting information. Before the main study, the researcher conducted a pilot study in schools that had characteristics similar to those of the sampled schools. Content validity was determined using expert judgment from specialist in the education management. Instrument reliability was established using the Cronbach alpha technique. Thematic analysis was used to analyze qualitative data, while quantitative data were analyzed using descriptive statistics in terms of frequencies, means, and inferential statistics in terms of regression analysis. Results: The results of this research show a prediction that for each increase in the leadership styles of secondary school principals, there was a 29.7% increase in security management. Recommendation: Major recommendation is that school leadership need to adopt the correct management strategies to ensure security. Furthermore, the community where the school is located should be involved in matters of student security and safety
Deinterlacing algorithm using fixed directional interpolation filter and adaptive distance weighting scheme

This paper proposes an efficient deinterlacing algorithm using the approximated sinc interpolator and adaptive distance weighting scheme that is suitable for real-time applications. The conventional edge-based deinterlacing algorithms provide poor image quality due to the limitation of the number of edge directions considered; moreover, the existing algorithms which consider many edge directions have high computational burden while still producing the staircase artifacts at the complex region. To overcome these problems, the proposed algorithm adopts an approximated sinc interpolator and adaptive distance weighting scheme which utilizes the pixel correlation. Simulation results show that the proposed algorithm provides outstanding performances in terms of both the objective and subjective image qualities, and it has lower computational complexity than the existing algorithms.
Evaluation of In Vitro Antibacterial Potential of Bacillus pseudomycoides Strain SB138

Bacillus species provide a natural source for the discovery of novel antibacterial substances. However, some of the Bacillus species still remained to be explored widely for their antagonism against harmful bacteria. One of them is Bacillus pseudomycoides which produces rhizoidal colonies on solid medium. The present study was aimed to explore antibacterial properties of B. pseudomycoides isolated from the rhizosphere soil of the indigenous Mangifera indica (mango) plant. Identification of the isolated strains was determined by sequencing their 16S rRNA genes. The isolates identified as B. pseudomycoides were screened for their antibacterial potential. In order to circumvent the trouble created from rhizoidal colony morphology of B. pseudomycoides , a colony mutant of a strain showing strong antibacterial activity was obtained by screening/selection method and designated as B. pseudomycoides strain SB138m. The sequence of 16S rRNA gene of both wild type and mutant strains of B. pseudomycoides was comparable. In vitro test for antagonism of B. pseudomycoides strain SB138m against indicator cells showed that the strain contained antibacterial potential. The present study shows inhibitory spectrum of B. pseudomycoides SB13m with conclusion that Bacillus species from a diverse environment and Proteus mirabilis from clinical environment were strongly inhibited.
Segmentation and fault–monocline relationships in the Lapstone Structural Complex, Sydney Basin, New South Wales

Abstract The 95 km-long Lapstone Structural Complex is a segmented structural association consisting of north-trending faults and monoclines in the western Sydney Basin between the Cumberland Basin to the east and lower Blue Mountains to the west. It has developed in a compressional regime. At depth, the Lapstone Structural Complex is most likely a deeply penetrating, west-dipping thrust fault that is seismogenic in the brittle middle crust. This structure has propagated upwards into the overlying Sydney Basin in the top ∼3 km of the crust and formed a suite of distinct fault and fault–monocline structures, including: (a) in the north, inferred imbricate faults at depth in the lower Sydney Basin dying out upwards into a well-displayed, major east-facing monocline (central limb has an overall consistent <20°E dip); (b) in the middle part of the complex, an east-facing monocline with dips increasing from west to east formed as a fault-propagation fold; and (c) as found in the south, a single thrust fault (Bargo and Nepean faults). The complex has a probable late Cenozoic age and has played a role in landscape development as shown by topography, uplifted river gravels and knick points along lower order streams. Therefore, it has formed late in the uplift history of the southeastern Australian highlands postdating uplift in the Cretaceous and uplift associated with basaltic eruptions in the Cenozoic. KEY POINTS The Lapstone Structural Complex is an association of segmented faults and monoclines formed at the tip of a deep-seated thrust fault. The largest structure in the complex is a gently east-dipping monocline formed above an inferred imbricate fault system in the lower Sydney Basin succession. Much of the middle and southern parts of the complex are single faults and a fault-propagation monocline related to a thrust fault at depth. The Lapstone Structural Complex is of late Cenozoic age and is most likely seismogenic.
Classification, seasonality and persistence of low-frequency atmospheric circulation patterns

Abstract Orthogonally rotated principle component analysis (RPCA) of Northern Hemisphere 1-month mean 700 mb heights is used to identify and describe the seasonality and persistence of the major modes of interannual variability. The analysis is detailed and comprehensive, in that 1) a high resolution, approximately equal-area 358-point grid is used for the virtually maximum possible 35-year period of record, 2) a positive bias in the NMC data base in the early 1950s in the subtropics is largely eliminated for the first time, and 3) homogeneous, separate analyses of each month of the year are carried out, detailing the mouth-to-month changes in the dominant circulation patterns. Winter results are similar to those of other recent RPCA and teleconnection studies except that some less obvious patterns are identified and further detail of the better-known patterns is provided. Two north-south dipole patterns are found over the Pacific Ocean (West Pacific Oscillation and East Pacific pattern) and over the Atla.
Caffeic Acid Inhibits Tumour Mass Formation in MG-63 Cells-induced Nude Mice

BACKGROUND: Formation of tumour mass is one symptom of osteosarcoma development. Caffeic acid has been known to provide effective treatment but has less side effect for some cancer therapy. Studies reported that caffeic acid might promote apoptosis in MG-63 osteosarcoma cells, however, the effect of caffeic acid treatment in preventing tumour mass formation has not been well elucidated, especially in MG-63 cells-induced nude mice in vivo.METHODS: MG-63 cells were pre-treated with 0, 1, or 10 µg/mL caffeic acid, and 6 hours after pre-treatment, MG-63 cells were injected into subcutaneous space of mice to induce osteosarcoma. Another model was also created by subcutaneously injecting MG-63 cells to the back of mice, and after 48 days, the visible tumour mass was injected intra-tumour with 0 or 10 µg/mL caffeic acid every 7 days for 6 times. After 90 days, mice were anaesthetised, and the nodule pictures were taken for observation and measurement. RESULTS: In pre-treated MG-63 cells-induced mice, volumes of the mass decreased in reverse with the dose of caffeic acid given. Ten µg/mL caffeic acid pre-treatment was able to significantly lower the mass volume compared to the untreated (p<0.05). Meanwhile, the intra-tumour treatment of 10 µg/mL caffeic acid, even though not significant, was able to inhibit tumour mass formation.CONCLUSION: Results of caffeic acid pre-treatment and caffeic acid treatment in tumour mass of mice show that caffeic acid is able to inhibit the MG-63 cells formation. This suggests that caffeic acid can be a potential anti-cancer agent.KEYWORDS: caffeic acid, osteosarcoma, MG-63 cells, tumour mass
Using an intensity‐scale technique to assess the added benefit of high‐resolution model precipitation forecasts

Deterministic precipitation forecasts from the 12‐ and 4‐km versions of the Unified Model (UM) were compared using an intensity‐scale technique. Averaging raw model output is always recommended to minimise grid‐scale errors. The retained detail in averaged 4‐km forecasts produces an improved prediction of larger accumulations. © Crown Copyright 2006. Reproduced with the permission of the Controller of HMSO. Published by John Wiley & Sons, Ltd.
A Two-Part Random-Effects Model for Semicontinuous Longitudinal Data

A semicontinuous variable has a portion of responses equal to a single value (typically 0) and a continuous, often skewed, distribution among the remaining values. In cross-sectional analyses, variables of this type may be described by a pair of regression models; for example, a logistic model for the probability of nonzero response and a conditional linear model for the mean response given that it is nonzero. We extend this two-part regression approach to longitudinal settings by introducing random coefficients into both the logistic and the linear stages. Fitting a two-part random-effects model poses computational challenges similar to those found with generalized linear mixed models. We obtain maximum likelihood estimates for the fixed coefficients and variance components by an approximate Fisher scoring procedure based on high-order Laplace approximations. To illustrate, we apply the technique to data from the Adolescent Alcohol Prevention Trial, examining reported recent alcohol use for students in grades 7–11 and its relationships to parental monitoring and rebelliousness.
Measurement of 3D plasma response to external magnetic perturbations in the presence of a rotating external kink

The detailed measurements of the 3D plasma response to applied external magnetic perturbations in the presence of a rotating external kink are presented, and compared with the predictions of a single-helicity linear model of kink mode dynamics. The modular control coils of the High Beta Tokamak-Extended Pulse (HBT-EP) device are used to apply resonant m/n = 3/1 magnetic perturbations to wall-stabilized tokamak plasmas with a pre-existing rotating 3/1 kink mode. The plasma response is measured in high-resolution with the extensive magnetic diagnostic set of the HBT-EP device. The spatial structures of both the naturally rotating kink mode and the externally driven response are independently measured and observed to be identical, while the temporal dynamics are consistent with the independent evolution and superposition of the two modes. This leads to the observation of a characteristic change in 3D field dynamics as a function of the applied field amplitude. This amplitude dependence is found to be different for poloidal and radial fields. The measured 3D response is compared to and shown to be consistent with the predictions of the linear single-helicity model in the “high-dissipation” regime, as reported previously [M. E. Mauel et al., Nucl. Fusion 45, 285 (2005)].
Factors Associated with Self-Reported Post/Long-COVID—A Real-World Data Study

Evidence suggests that Post/Long-COVID (PLC) is associated with a reduced health-related quality of life, however little knowledge exists on the risk factors that contribute to PLC. The objective of this prospective real-world data study was to evaluate factors associated with PLC using national online survey data. Adjusted multivariable regression analyses were performed using the software R. Between 14 April and 15 June 2021, 99 registered individuals reported to have suffered from PLC symptoms and the most common PLC symptoms reported were fatigue, dyspnoea, decreased strength, hyposmia, and memory loss. The odds of individuals suffering from COVID-19-associated anxiety, hyposmia, or heart palpitations developing PLC were eight times (OR 8.28, 95% CI 1.43–47.85, p < 0.01), five times (OR 4.74, 95% CI 1.59–14.12, p < 0.005), or three times (OR 2.62, 95% CI 1.72–3.99, p < 0.01) higher, respectively, than of those who had not experienced these symptoms. Individuals who experienced fatigue while having COVID-19 were seven times more likely to develop PLC fatigue than those who had not (OR 6.52, 95% CI: 4.29–9.91, p < 0.0001). Our findings revealed that 13% of the individuals who had previously suffered from COVID-19 subsequently reported having PLC. Furthermore, COVID-19-associated anxiety, hyposmia, heart palpitations, and fatigue were, among others, significant determinants for the development of PLC symptoms. Hyposmia has not previously been reported as an independent predictive factor for PLC. We suggest closely monitoring patients with COVID-19-induced fatigue, heart palpitations, and anxiety, as these symptoms may be predictors of PLC symptoms, including fatigue.
Knowledge, Attitude, Practice and Perceived Barriers on Palliative Care Pain Management among the Healthcare Providers: A Single Centre Study

Healthcare providers’ knowledge and attitude on cancer pain control remain a debatable topic. The study aims to determine the knowledge, attitude, practice and perceived barriers among the healthcare providers in delivering effective analgesic in palliative care. A cross-sectional study was conducted among the specialists and post-graduate students from the medical and surgical programme using the convenience sampling method. A set of questionnaires related to the pain management in palliative patients was distributed. The questionnaire covered demographic characteristics, knowledge, attitudes, practice, and perceived barrier regarding cancer pain management. A total of 300 questionnaires were analysed with 75% response rate. About two-third (66.3%) of the respondents have knowledge deficit to prescribe opioids in pain management of palliative care patients. The medical specialty and lacking pain management training were significant factors associated with knowledge deficit. About half (48.3%) of the respondents thought that cancer pain therapy could be satisfactorily achieved as an outcome and 58.7% respondents admitting to practice daily pain assessment in patients with cancer. The main perceived barriers in managing pain for palliative patients were inadequate pain assessment (71.2%) and inadequate staff knowledge (53.6%). The knowledge differences among the different medical specialties and lack of pain management training have significantly impacted the pain management in palliative patients. A targeted educational strategy for pain management in palliative care patients is needed to improve physicians’ knowledge and clinical practice.
Quiver varieties and self-injective algebras

In this paper, we introduce a new class of quiver varieties, recovering as special cases the cyclic and classical Nakajima quiver varieties. We show that the geometry of the new quiver varieties is closely linked to the representation theory of a suitable finitely-generated algebra $\mathcal{P}$, which is self-injective if $Q$ is of ADE Dynkin type. The affine quiver variety, defined as GIT quotient, is shown to be isomorphic to the moduli space of representations of a finitely-generated algebra $\mathcal{S}$. We construct a functor $\Psi$ establishing a bijection between the strata of the affine quiver variety and the isomorphism classes of objects in proj $\mathcal{P}$. Under $\Psi$, the degeneration order between strata corresponds to Jensen--Su--Zimmermann's degeneration order on proj $\mathcal{P}$. Furthermore, we use $\Psi$ to realize the fibres of Nakajima's projection map $\pi$ as quiver Grassmannians of $\mathcal{P}$. The algebra $\mathcal{P}$ specializes to the preprojective algebra if we consider classical quiver varieties. Finally, we use our results to construct desingularisations of quiver Grassmannians of modules of self-injective algebras of finite type.