Miracle-dz/UniFAR-FTUs huggingface dataset:
Características químicas de substratos formulados com lodo de esgoto para produção de mudas florestais

The objective of this study was to characterize the chemical properties and compositions of substrates formulated with sewage sludge in different combinations. The substrates were produced using organic waste and vermiculite, in order to obtain an adequate growth medium for the forest seedling. An analysis was made of the total and the available nutrient content on the 26 substrates, made with sewage sludge and vermiculite and waste from coconut fiber, in natura coffee straw, organic compost, carbonized rice husk and in natura rice husk, using the following ratios: 100:0, 80:20, 60:40, 40:60 and 20:80 (sewage sludge:material), and also a control consisting of commercial substrate. The commercial substrate provided the highest means for available levels of phosphorus, calcium and magnesium. The sewage sludge provided an increase of fertility of the substrates, with increased nutrient levels, mainly phosphorus, nitrogen and calcium. The substrates formulated with sewage sludge and organic compost, regardless of their ratios, were considered the most adequate for the production of seedling of forest species.
A Single Plasmid of Nisin-Controlled Bovine and Human Lactoferrin Expressing Elevated Antibacterial Activity of Lactoferrin-Resistant Probiotic Strains

Lactoferrin (LF) is a multifunctional protein found in mammals, and it shows broad-spectrum antimicrobial activity. To improve the functional properties of specific probiotics in order to provide both the beneficial characteristics of lactic acid bacteria and the biological activity of LF, cDNAs of bovine LF (BLF), human LF (HLF), or porcine LF (PLF) were cloned into a nisin-inducible plasmid. These were then transformed into the selected eight probiotics, which are LF-resistant hosts. Expression of recombinant LFs (rLFs) was analyzed via SDS-PAGE and Western blot analysis. Although the selected host strains may not contain the nisRK genes (NisK, the sensor kinase; NisR, the regulator protein), the components of autoregulation, a low level of LFs expression can be successfully induced by using nisin within bacterial cells in a time-dependent manner in three engineered clones, including Lactobacillus delbrueckii/HLF, L. delbrueckii/BLF, and L. gasseri/BLF. Lactobacillus delbrueckii and Lactobacillus gasseri originate from yogurt and human milk, respectively, and both strains are functional probiotic strains. Therefore, we further compared the antibacterial activities of disrupted recombinant probiotic clones, conventional strains (host control), and vector control ones by using agar diffusion and broth inhibition analysis, and the expression of rLFs in the above three clones considerately improved their antibacterial efficacies against four important food-borne pathogens, namely, Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, and Salmonella enterica. In conclusion, this study provides a simple strategy for the production of functional LFs (BLF and HLF) in both functional and LF-resistant hosts for applications in the field.
Defect monitoring using scanning photoluminescence spectroscopy in multicrystalline silicon wafers

Scanning photoluminescence (PL) spectroscopy was performed on as-grown and processed multicrystalline silicon (mc-Si) wafers to investigate the defect distribution affecting the efficiency of solar cells. In highly inhomogeneous mc-Si prepared by (i) edge-defined film-fed growth or (ii) a block-casting technique, regions of a wafer with enhanced recombination activity and reduced minority carrier lifetime exhibit an intensive `defect' PL band at room temperature with the maximum at about 0.8 eV. By comparing PL mapping with the distribution of dislocations, we present experimental evidence that the 0.8 eV band corresponds to electrically active dislocation networks. This was confirmed using low-temperature PL spectroscopy, which revealed a characteristic quartet of the dislocation D-lines. One of these dislocation lines, D1, can be tracked as temperature increases and linked to the `defect' band. Strong linear polarization of the 0.8 eV PL band corresponds to a preferential localization of defects in regions with a high level of elastic stress measured with scanning infrared polariscopy. The origin of the 0.8 eV PL band is attributed to dislocations contaminated with impurity precipitates.
Use of Wire Screens as a Fan Model Filter

A fan model filter consists of multiple layers of parallel, equidistant cylinders, having axes oriented randomly to each other and perpendicular to the direction of flow. Regular wire screens with uniform wire diameters and openings resemble the fan model filter. This report describes measurements of the pressure drop across layers of screens and the single-fiber collection efficiency of screens for monodisperse aerosols. Our results on several different mesh screens agreed with the theoretical prediction from fan model filtration. In the size range of 0.01 to 1.0 μm, the diffusion and interception mechanisms were responsible for aerosol collection. Further, minimum efficiency existed for particle sizes between 0.4 and 0.7 μm, where the transition between diffusion and interception occurred. This report also describes the application of these results using these screens in a diffusion battery as cell material.
Prognosis after surgery for gastric adenocarcinoma in the Swedish Gastric Cancer Surgery Study (SWEGASS)

Abstract Background Most studies examining prognostic factors after gastrectomy come from selected patients and non-Western populations. This nationwide population-based cohort study aims to identify prognostic factors after surgery for gastric adenocarcinoma in an unselected Western cohort. Methods This study included 98% of patients who underwent gastrectomy for gastric adenocarcinoma in Sweden in 2006–2015, with follow-up through 2019. Data were collected from medical records and national registries. Exposures were sex, age, education, comorbidity, tumor sub-localization, tumor stage, calendar period, and pre-operative chemotherapy. Outcomes were 3-year all-cause and disease-specific mortality. Cox regression produced hazard ratios (HRs) with 95% confidence intervals (95% CIs), adjusted for the other study exposures. Results Among all 2154 patients, 3-year all-cause mortality was 53.3%. Factors influencing 3-year all-cause mortality after multivariable adjustment were tumor stage (stage IV vs. stage 0–I: HR 8.72, 95% CI 6.77–11.24), comorbidity (Charlson comorbidity score ≥2 vs. 0: HR 1.63, 95% CI 1.39–1.90), age (>75 vs. <65 years: HR 1.48, 95% CI 1.24–1.78), and calendar period (2006–2010 vs. 2011–2015: HR 0.83, 95% CI 0.73–0.95). No independent prognostic influence was found for sex (women vs. men: HR 1.01, 95% CI 0.85–1.09), pre-operative chemotherapy (yes vs. no: HR 0.92, 95% CI 0.78–1.08), tumor sub-localization (non-cardia vs. cardia: HR 1.01, 95% CI 0.83–1.22), or education (≥13 vs. ≤9 years: HR 0.89, 95% CI 0.74–1.07). The results were similar for 3-year disease-specific mortality. Conclusion Survival after gastrectomy for gastric adenocarcinoma needs further improvement. Tumor stage, comorbidity, age, and calendar period were independently prognostic, while sex, pre-operative chemotherapy, tumor sub-localization, and education were not.
A Pilot Study on Baseline Fungi and Moisture Indicator Fungi in Danish Homes

In many complaint cases regarding bad indoor environments, there is no evidence of visible fungal growth. To determine if the problems are fungi-related, dust sampling is the method of choice among building surveyors. However, there is a need to differentiate between species belonging to a normal, dry indoor environment and species belonging to a damp building envelope. The purposes of this pilot study were to examine which fungal species are present in problem-free Danish homes and to evaluate different detection and identification methods. Analyses showed that the fungal diversity outside was different from the diversity inside and that the composition of fungal species growing indoors was different compared to those found as spores, both indoors and outdoors. Common for most homes were Pseudopithomyces chartarum, Cladosporium allicinum and Alternaria sect. Infectoriae together with Botrytis spp. , Penicillium digitatum and Pen. glabrum. The results show that ITS sequencing of dust samples is adequate if supported by thorough building inspections and that food products play as large a role in the composition of the baseline spora as the outdoor air and surrounding vegetation. This pilot study provides a list of baseline fungal species found in Danish homes with a good indoor environment.
Chronic intermittent hypoxia increases excitability and synaptic excitation of protrudor and retractor hypoglossal motoneurones

Dysfunctions in the hypoglossal control of tongue extrinsic muscles are implicated in obstructive sleep apnoea (OSA) syndrome. Chronic intermittent hypoxia (CIH), an important feature of OSA syndrome, produces deleterious effects on the motor control of oropharyngeal resistance, but whether the hypoglossal motoneurones innervating the tongue extrinsic muscles are affected by CIH is unknown. We show that CIH enhanced the respiratory‐related activity of rat hypoglossal nerve innervating the protrudor and retractor tongue extrinsic muscles. Intracellular recordings revealed increases in respiratory‐related firing frequency and synaptic excitation of inspiratory protrudor and retractor hypoglossal motoneurones after CIH. CIH also increased their intrinsic excitability, depolarised resting membrane potential and reduced K+‐dominated leak conductance. CIH affected the breathing‐related synaptic control and intrinsic electrophysiological properties of protrudor and retractor hypoglossal motoneurones to optimise the neural control of oropharyngeal function.
Adipokines and Autoimmunity in Inflammatory Arthritis

Adipokines are adipose tissue-derived factors not only playing an important role in metabolism but also influencing other central processes of the body, such as inflammation. In autoimmune diseases, adipokines are involved in inflammatory pathways affecting different cell types. Many rheumatic diseases belong to the group of autoimmune diseases, for example rheumatoid arthritis (RA) and psoriatic arthritis. Due to the autoimmune responses, a chronic inflammatory milieu develops, which affects the whole body, including adipose tissue. Metabolic alterations such as obesity influence inflammatory responses in autoimmune diseases. Adipokines are bioactive mediators mainly produced by adipose tissue. Due to alterations of systemic adipokine levels, their role as biomarkers with diagnostic potential has been suggested in the context of rheumatic diseases. In the affected joints of RA patients, different synoviocytes but also osteoclasts, osteoblasts, and chondrocytes produce several adipokines, contributing to the unique inflammatory microenvironment. Adipokines have been shown to be potent modulatory effectors on different cell types of the immune system but also local cells in synovial tissue, cartilage, and bone. This review highlights the most recent findings on the role of adipokines in the pathophysiology of inflammatory arthritis with a distinct focus on RA in the quickly developing research field.
Adaptive Gaussian Mixture Model Driven Level Set Segmentation for Remote Pulse Rate Detection

This paper presents an approach for pulse rate extraction from videos. The core of the presented approach is a novel method to segment and track a suitable region of interest (ROI). The proposed method combines level sets with subject-individual Gaussian Mixture Models to yield a time varying ROI. The ROI builds up from multiple homogeneous skin areas under constraints regarding the area and contour length of the ROI. Together with state of the art signal processing methods our approach yields an Mean Average Error (MAE) of 2.3 bpm, 1.4 bpm and 2.7 bpm on own data, the PURE database and the UBFC-rPPG database, respectively. Therewith, our method performs equal or better compared to widely used approaches (e.g. the KLT tracker instead of the proposed image processing yields an MAE of 2.6 bpm, 2.6 bpm and 4.4 bpm). Such results and the 2nd place with a MAE of 7.92 bpm in the 1st Challenge on Remote Physiological Signal Sensing prove the applicability of the proposed method. The taken approach, however, bears further potential for optimization in the context of photoplethysmography imaging and should be transferable to other segmentation tasks as well.
Do Messages Matter? Investigating the Combined Effects of Framing, Outcome Uncertainty, and Number Format on COVID-19 Vaccination Attitudes and Intention

ABSTRACT Guided by prospect theory, the current study aims to explore Chinese adults’ attitudes and intention to get vaccinated against COVID-19 and investigate the effects of message frames (gain vs. loss), outcome uncertainty (certain vs. uncertain), and number format (frequency vs. percentage) on vaccination attitudes and intention. Participants (n = 413) were randomly assigned to one of the eight experimental conditions and participated in the online experiment. The results showed that Chinese adults’ attitudes toward COVID-19 vaccination were highly favorable, and the vaccination intention was high; age and education were positively correlated with attitudes and intention. The results also showed that message frames, outcome uncertainty, and number format did not have significant main or interaction effects on vaccination attitudes and intention. The discussion focused on how Chinese culture and contextual factors may have influenced the results of the study, as well as the implications and suggestions for future studies.
Arbuscular Mycorrhizal Fungal Communities in the Soils of Desert Habitats

Deserts cover a significant proportion of the Earth’s surface and continue to expand as a consequence of climate change. Mutualistic arbuscular mycorrhizal (AM) fungi are functionally important plant root symbionts, and may be particularly important in drought stressed systems such as deserts. Here we provide a first molecular characterization of the AM fungi occurring in several desert ecosystems worldwide. We sequenced AM fungal DNA from soil samples collected from deserts in six different regions of the globe using the primer pair WANDA-AML2 with Illumina MiSeq. We recorded altogether 50 AM fungal phylotypes. Glomeraceae was the most common family, while Claroideoglomeraceae, Diversisporaceae and Acaulosporaceae were represented with lower frequency and abundance. The most diverse site, with 35 virtual taxa (VT), was in the Israeli Negev desert. Sites representing harsh conditions yielded relatively few reads and low richness estimates, for example, a Saudi Arabian desert site where only three Diversispora VT were recorded. The AM fungal taxa recorded in the desert soils are mostly geographically and ecologically widespread. However, in four sites out of six, communities comprised more desert-affiliated taxa (according to the MaarjAM database) than expected at random. AM fungal VT present in samples were phylogenetically clustered compared with the global taxon pool, suggesting that nonrandom assembly processes, notably habitat filtering, may have shaped desert fungal assemblages.
Factors That Optimize Reproductive Efficiency in Dairy Herds with an Emphasis on Timed Artificial Insemination Programs

Simple Summary Reproductive efficiency is critical for profitability of dairy operations. The first part of this manuscript discusses the key physiology of dairy cows and how to practically manipulate this reproductive physiology to produce timed artificial insemination (TAI) programs with enhanced fertility. In addition, there are other critical factors that also influence reproductive efficiency of dairy herds such as genetics, management of the transition period, and body condition score changes and improve management and facilities to increase cow comfort and reduce health problems. Using optimized TAI protocols combined with enhancing cow/management factors that impact reproductive efficiency generates dairy herd programs with high reproductive efficiency, while improving health and productivity of the herds. Abstract Reproductive efficiency is closely tied to the profitability of dairy herds, and therefore successful dairy operations seek to achieve high 21-day pregnancy rates in order to reduce the calving interval and days in milk of the herd. There are various factors that impact reproductive performance, including the specific reproductive management program, body condition score loss and nutritional management, genetics of the cows, and the cow comfort provided by the facilities and management programs. To achieve high 21-day pregnancy rates, the service rate and pregnancy per artificial insemination (P/AI) should be increased. Currently, there are adjustments in timed artificial insemination (TAI) protocols and use of presynchronization programs that can increase P/AI, even to the point that fertility is higher with some TAI programs as compared with AI after standing estrus. Implementation of a systematic reproductive management program that utilizes efficient TAI programs with optimized management strategies can produce high reproductive indexes combined with healthy cows having high milk production termed “the high fertility cycle”. The scientific results that underlie these concepts are presented in this manuscript along with how these ideas can be practically implemented to improve reproductive efficiency on commercial dairy operations.
Duvelisib (Copiktra) in relapsed or refractory chronic lymphocytic leukemia: safety and efficacy

ABSTRACT Introduction: The treatment landscape of chronic lymphocytic leukemia (CLL) has changed dramatically with the introduction of novel targeted therapies. Phosphoinotiside-3 kinase (PI3K) is a B-cell receptor-associated kinase that is essential for growth, survival and migration of neoplastic B cells and is implicated in disease progression and drug resistance. Area covered: PI3K inhibitors idelalisib and duvelisib are approved in therapy of relapsed/refractory (R/R) CLL. In this drug profile review, we focus on duvelisib, an oral inhibitor of PI3Kδ and PI3Kγ isoforms, in treatment of patients with R/R CLL. Expert opinion: Duvelisib, a selective dual PI3Kδ/γ inhibitor, achieves meaningful efficacy in CLL, including in patients with high-risk features. Duvelisib therapy may be particularly appropriate for patients who are suboptimal candidates for Bruton tyrosine kinase inhibitors (BTK), such as those with cardiac conditions, poorly controlled hypertension, or requiring full-dose anticoagulation. Tumor lysis monitoring is not necessary with duvelisib, rendering advantage over the BCL2 inhibitor venetoclax. Patients who progress on both BTK inhibitors and venetoclax may be particularly good candidates for duvelisib therapy. With close monitoring and management of adverse events, duvelisib will continue to have a role in therapy of R/R CLL.
Convolutional Neural Networks With Gated Recurrent Connections

The convolutional neural network (CNN) has become a basic model for solving many computer vision problems. In recent years, a new class of CNNs, recurrent convolution neural network (RCNN), inspired by abundant recurrent connections in the visual systems of animals, was proposed. The critical element of RCNN is the recurrent convolutional layer (RCL), which incorporates recurrent connections between neurons in the standard convolutional layer. With increasing number of recurrent computations, the receptive fields (RFs) of neurons in RCL expand unboundedly, which is inconsistent with biological facts. We propose to modulate the RFs of neurons by introducing gates to the recurrent connections. The gates control the amount of context information inputting to the neurons and the neurons’ RFs therefore become adaptive. The resulting layer is called gated recurrent convolution layer (GRCL). Multiple GRCLs constitute a deep model called gated RCNN (GRCNN). The GRCNN was evaluated on several computer vision tasks including object recognition, scene text recognition and object detection, and obtained much better results than the RCNN. In addition, when combined with other adaptive RF techniques, the GRCNN demonstrated competitive performance to the state-of-the-art models on benchmark datasets for these tasks.
Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond

Cardiogenic shock following acute myocardial infarction is associated with high mortality, substantially unchanged for the previous 20 years. Several approaches have been sought to achieve a therapeutic breakthrough, from myocardial revascularization strategies to the use of mechanical circulatory support. Many issues are, as yet, unresolved. Systemic inflammation seems to play a key role but is still lacking in effective therapies, and is potentially compounded by the death spiral of hypoperfusion and/or artificial devices. In this review, a multitarget approach to cardiogenic shock following acute myocardial infarction is proposed.
Association Between Deep Posterior Cervical Paraspinal Muscle Morphology and Clinical Features in Patients With Cervical Ossification of the Posterior Longitudinal Ligament

Study Design: A retrospective observational study. Objective: To clarify the association of the paraspinal muscle area and composition with clinical features in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Methods: Consecutive patients with cervical OPLL who underwent cervical magnetic resonance imaging (MRI) before surgery were reviewed. The cross-sectional area (CSA) and fatty infiltration ratio (FI%) of deep posterior cervical paraspinal muscles (multifidus [MF] and semispinalis cervicis [SCer]) were examined. We assessed the association of paraspinal muscle measurements with the clinical characteristics and clinical outcomes, such as Neck Disability Index (NDI) score. Moreover, we divided the patients into 2 groups according to the extent of the ossified lesion (segmental and localized [OPLL-SL] and continuous and mixed [OPLL-CM] groups) and compared these variables between the 2 groups. Results: 49 patients with cervical OPLL were enrolled in this study. The FI% of the paraspinal muscles was significantly associated with the number of vertebrae (ρ = 0.283, p = 0.049) or maximum occupancy ratio of OPLL (ρ = 0.397, p = 0.005). The comparative study results indicated that the NDI score was significantly worse (OPLL-SL, 22.9 ± 13.7 vs. OPLL-CM, 34.4 ± 13.7) and FI% of SCer higher (OPLL-SL, 9.1 ± 1.7% vs. OPLL-CM, 11.1 ± 3.7%) in the OPLL-CM group than those in the OPLL-SL group. Conclusions: Our results suggest that OPLL severity may be associated with fatty infiltration of deep posterior cervical paraspinal muscles, which could affect neck disability in patients with cervical OPLL.