Miracle-dz/UniFAR-FTUs huggingface dataset:
Selective screening for inborn errors of metabolism using tandem mass spectrometry in West Kazakhstan children: study protocol

Data on the prevalence of most inborn errors of metabolism are still unavailable in Kazakhstan. The study aims to perform selective screening for hereditary metabolic diseases among patients aged from 1 day to 18 years in western Kazakhstan using the LC-MS/MS method, with establishing the reference values for the content of amino acids, acylcarnitines, and succinylacetone in blood samples of healthy children. Tasks: 1. To assess the burden of metabolic disorders detected by LC-MS/MS in western Kazakhstan by examination of children at clinical risk in pediatric clinics throughout the region; https://www.frontiersin. org/register? returnUrl=https://loop.frontiersin. org 2. To set the reference values of metabolites in the child population; 3. To analyze the age distribution, prevalence, and age of onset for each identified IEM, further comparing the obtained findings with those from previously published reports in other populations. Methods: To set the reference values of 51 metabolites in the child population, 750 healthy children will be included. The selective screening will be performed among 1,500 patients aged 1 day to 18 years with suspected hereditary metabolic disorders. Anticipated results: The results of selective screening will be interpreted by comparison with the reference values established. Diagnosis will be based on clinical signs, blood levels of amino acids, acylcarnitines, succinylacetone, and urine levels of organic acids and tests for gene mutations. An assessment of 37 inborn errors of metabolism frequencies in high-risk children will be performed. The research will further develop the national as selective as expanded newborn screening programs. The study was registered in clinicaltrials. gov (https://www.clinicaltrials.gov/study/NCT05910151) on 16 June 2023.
Socio-Cultural Factors Influencing Medical Circumcision of Males Performed Voluntarily Uptake in Turkana County

Purpose: Kenya is amongst six high-burden nations in Africa grappling high HIV infections. Approximately 91.2% of Kenyan men have undergone circumcision. However, male circumcision is not traditionally practiced in Turkana community with male circumcision rates ranging from 5-10%. The study's sought to identify socio-cultural factors Influencing Medical Circumcision of Males Performed Voluntarily Uptake in Turkana County. Materials and Methods: Utilizing a researcher-administered survey, KII schedules, and a FGD guide, data was gathered. 434 males made up the sample size. An analytical cross-sectional methodology was used in the investigation. The data was analyzed with SPSS 22. Results showed that of 374 male participants in the study, 79.9% had undergone circumcision, 77.0% were aged 18-35 years, 94.1% were Christians, and 44.7% were unemployed while 54.8% were married. The overall mean scores of responses for socio-cultural factors, psychosocial factors, socio-economic factors, and information sources factors were 3.230 (neutral), 3.602 (positive), 2.894 (negative) and 3.48 (neutral), respectively. Findings: The study found that socio-cultural factors was significant predictors of embracing VMMC. Sociocultural factors were about 0.30 times more likely to increase uptake of VMMC [OR=0.301; 95% CI: 0.081-0.52, P=0.007]. Conclusion: The study recommends that policies addressing main VMMC uptake amongst men in Turkana County should incorporate public participation, traditional leaders and local administrators for societal acceptance. There is need for effective sensitization and advocacy for behavioral change, mobilization and ownership of the initiative by the community. Policies should advocate for local leadership training.
Impact of saccharomyces enriched with selenium on growth performance and metabolic status of sheep exposed to heat stress.

ABSTRACT: T he objective of this research was to determine the effect saccharomy-ces enriched with selenium yeast (SeY) on Rahmani sheep and to evaluate the influence of the oral supplementation of saccharomyces enriched selenium on growth performance, Haematobiochemical, and antioxidant parameters in such sheep. Twenty Rahmani sheep were allocated into 4 groups , each group have five sheep, which were control group : received basal diet and not exposed to heat stress, Heat stress group (HS): received basal diet and exposed to heat stress, heat stressed with Saccharomyces enriched selenium(HS+SeY):received basal diet containing Saccharomyces enriched selenium and exposed to heat stress, non-heat stressed group with Saccharomyces enriched selenium (NHS+SeY):received basal diet with Saccharomyces enriched selenium and not exposed to heat stress. Temperature and humidity index were calculated. Experiment undergoes for two months (July and August). The results showed that Saccharomyces enriched selenium causes significant improvement in feed efficiency in sheep under heat stress. Saccharomyces enriched selenium supplementation to Hs sheep showed improvement of Haematological indicator and tendency toward normal values indicating positive effect of Saccharomyces enriched selenium. Furthermore, the findings of the study demonstrated that selenium enriched saccharomyces diet have positive impact on various blood metabolites, such as glucose, total protein, albumin, globulin, liver and kidney enzymes, and triglyceride
What are the determinants of non-performing financing in Islamic banks during Covid-19?

Several trading and banking sectors strive to survive the current pandemic. Despite the intense competition in the financial industry recently, Islamic banks have demonstrated remarkable growth. However, the issue of defaults in Islamic banks often arises, where debtors cannot repay the obtained financing, disrupting banking performance. This research investigates the factors influencing funding troubles in Islamic banks, especially during COVID-19. Specifically, this study examines whether factor-specific banks and macroeconomics in Islamic banks control troubled funding. The research utilizes quarterly data from Islamic banks in Southeast Asia (Malaysia and Indonesia) from 2020 to 2021. The findings indicate that liquidity risk, inefficiency, and economic growth do not significantly affect troubled financing in Islamic banks. At the same time, capital, profitability, and inflation significantly negatively impact funding troubles. These results recommend that Islamic banks increase their capital and profitability proportion to reduce the risk of funding trouble.
Analysis of Patient Safety Culture Post of the COVID-19 Outbreak Peak

BACKGROUND: Patient safety culture is an important indicator of the quality of health services. The COVID-19 pandemic resulted in a health emergency that contributed to the dynamics of handling and providing services in the health sector and put significant pressure on the health sector. Health services during the COVID-19 pandemic faced serious challenges. During a pandemic, safe and high-quality care is an important goal in the patient safety care system, which is an effort to prevent mistakes in providing services. METHOD: This study used analytical descriptive method with a cross-sectional approach and continued with correlation and comparative studies. The sample in this study amounted to 323 respondents by non-probability sampling. RESULTS: At the beginning of the pandemic, especially during the first spike in cases, there was a decline in patient safety culture, especially in the reporting of patient safety incidents. This decline was immediately corrected from 27.6% after the peak of the first pandemic to 52.4% after the peak of the second pandemic to 70% after the peak of the third pandemic. The dimension of teamwork between units had the largest correlation (r = 0.506) with a value of p = 0.000 in the first post-peak pandemic; in the post-peak of the second pandemic, the overall perception dimension of patient safety was the dimension with the largest correlation value (r = 0.547) with a value of p = 0.000. In the third post-peak pandemic, the supervisor/manager expectation dimension and actions that support patient safety were the dimensions that had the largest correlation value (r = 0.255) with a value of p = 0.000. CONCLUSION: There are dominant factors related to the quality of implementing patient safety culture in each post- peak pandemic and there are differences in the quality of implementing patient safety culture for each post-peak pandemic.
A review: using legumes to develop products for patients with psychiatric disorders

Mortality rates and co-morbidities are high in people with psychiatric disorders. These patients have unhealthy dietary habits, which include increased consumption of fast food, snacks, sweets, saturated fats, and reduced consumption of protein, fruits, vegetables, and legumes, which contributes to the risk of developing chronic diseases such as obesity, type 2 diabetes, and cardiovascular disease. Unhealthy and monotonous eating habits lead to a significant lack of nutrients such as protein, omega-3 fatty acids, B-group vitamins, and fibre. The aim of the literature review is to investigate the main diet problems of patients with psychiatric disorders and, based on the studies on the nutritional value of legumes, to evaluate their suitability for the development of new products for patients with psychiatric disorders. Studies show the beneficial effects of legumes on the regulation of rapid fluctuations in cholesterol, blood pressure, excess body weight, and glucose levels, which in general delay the formation of inflammation and reduce the risk of psychiatric disorders. The benefits of legumes are due to their high protein and fibre content, low fat content, and content of iron, copper, magnesium, zinc, and B-group vitamins. In addition, legumes contain bioactive compounds that contribute to the prevention of chronic diseases.
Application of Game Based Learning Using Crossword Media in Improving English Vocabulary

English has become an important international language in communication between countries, business, technology, and access to educational resources around the world. In this case, English language skills are not only a necessity, but also a competitive advantage in facing global competition. However, unfortunately, English learning for Selat village students is currently still not achieving maximum results due to the low interest in learning and motivation of students in learning English vocabulary. Therefore, this research was conducted with the aim of increasing children's understanding of basic English vocabulary in Selat Village through the application of Game Based Learning (GBL) with Crossword media. The method used is PALS (Participatory Action and Learning System), namely a participatory approach that involves students and teachers in planning, implementing and evaluating learning actions. Initial problem identification indicates low mastery of English vocabulary and lack of student motivation. The improvement plan is in the form of implementing Game Based Learning using crossword puzzles. The results showed a substantial increase in students' understanding and memorization of English vocabulary, with students' positive response and enthusiasm for this learning method. The conclusion of this research is that Game Based Learning using crossword puzzles is effective in increasing students' understanding of basic English vocabulary in Selat Village.
PREVALENCE OF ANISOMETROPIC AMBLYOPIA AMONGST SCHOOL CHILDREN IN SOHAG GOVERNMENT

Purpose : Amblyopia is the blurry vision which means a decrease in best-corrected visual acuity in one or both eyes due to the lack of binocular vision due to the neurological deficit in the visual system. It is more common in school children and could be a major problem leading to poor performance in education. In general, the rate of children having amblyopia is from 0.13% to 12.9 %. In this study, we aim to estimate its prevalence in school children in Sohag governorate by identifying the factors that cause risks. Method : In this cross-sectional study, 500 school age children in Sohag government were screened for the presence of anisometropic amblyopia and associated risk factors. Results : Amblyopia was prevalent amongst 6% of children (6-18 years old) in Sohag governorate. Anisometropic amblyopia was found in 3.2%. Only 2% of children had visual acuity in the better eye < 6/60, with amblyopia more prevalent in these children. High hyperopia appeared amongst 1.8% of subjects with amblyopia more prevalent in this type of error than in other types.
Assessment of dentoskeletal effects concomitant with skeletally anchored maxillary protraction in orthodontic skeletal Class III patients

Objective : The current prospective study evaluated the dentoskeletal effects subsequent to maxillary protraction with facemask in skeletal Class III malocclusion with or without skeletal anchorage. Materials and methods: Fourteen pre-pubertal patients with comparable chronological age, 9 boys and 5 girls, were randomly allocated to a control group and skeletally anchored facemask (SAFM) group. All patients were treated for 6 months with maxillary protraction via facemask attached to an intra-oral appliance comprising an acrylic splint without palatal expander. In SAFM group, the intraoral appliance was connected to palatal miniscrews of 1.6 mm diameter and 10 mm length to obtain skeletal anchorage. Dentoskeletal variables were analyzed and compared within and between both groups via lateral cephalometric radiographs before (T1) and after maxillary protraction (T2). Results: Within each group; facemask therapy resulted in a significant maxillary skeletal advancement in group I (P ≤ 0.05)highly significant maxillary advancement in group II (P ≤ 0.01) and non-significant maxillary incisor proclination and retroclination in group I and II respectively (P ≥ 0.05). Regarding the mandible, it was non-significantly backward positioned in both groups (P ≥ 0.05). However, the inclination of the lower incisor underwent a highly significant decrease in both groups (P ≤ 0.01). The vertical dimension was significantly increased in both groups after treatment (P ≤ 0.05). Moreover, a comparison of dentoskeletal changes between the two groups revealed a significant difference in the anteroposterior maxillary skeletal changes only in favour of group II (P ≤ 0.05). Conclusions: The use of palatal miniscrews in conjunction with a facemask for maxillary protraction revealed a more favourable maxillary skeletal effect.
Character Association and Path Analysis Studies at Genotypic Level on Some Genotypes of Safflower (Carthamus tinctorius L.)

Safflower (Carthamus tinctorius L.) is one of the oldest domesticated crops. It has been grown since ancient times both as a dye as well as an oilseed crop in a wide range of geographical regions (Knowles, 1976). It is a member of the family Compositae or Asteraceae, genusCarthamus, tribeTubiflorae, sub division-Angiosperm of divisionPhanerogams. It is mainly grown in Maharashtra, Karnataka and parts of Andhra Pradesh, Madhya Pradesh, Orissa, Bihar, etc. Maharashtra and Karnataka are the two most important safflower growing states accounting for 72 and 23 per cent of area and 63 and 35 per cent of production, respectively. Safflower is cultivated in an area of 600 hectares with a production of 200 tonnes and a productivity of 333 kg/ hectare in Chhattisgarh. Whereas in India the Safflower is grown in an area of 1, International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 03 (2019) Journal homepage: http://www.ijcmas. com
Exploring the Interplay of Working Memory, Apathy, and Mood/Emotional Factors

Background: Previous investigations on healthy humans showed conflicting evidence regarding the impact of mood on working memory performance. A systematic investigation of how mood affects apathy levels in healthy participants is currently missing. Methods: We administered a visuospatial (VS) and a numerical (N) n-back task to a sample of 120 healthy individuals. In these participants, using a series of questionnaires, we also evaluated apathy, mood, working memory, perceived stress, PTSD symptoms caused by the COVID-19 pandemic outbreak, and general psychiatric symptoms. Successively, we investigated their performance in the n-back task as a function of scores to these questionnaires. Results: Participants performed better in the N block than in the VS one. Their accuracy decreased as a function of the n-back difficulty. We reported no differences in working memory performance or apathy as a function of mood, stress, or PTSD symptoms. We found that phobic anxiety negatively predicted accuracy to the numerical n-back task and that subjects with greater anxiety and difficulty in regulating emotions also showed higher levels of withdrawal from the task. Conclusion: The study’s results suggest that while mood did not significantly affect working memory performance, strong associations were found between WMQ scores and working memory capabilities.
Analytic and Data-Driven Force Prediction for Vacuum-Based Granular Grippers

As manufacturing and assembly processes continue to require more adaptable systems for automated handling, innovative solutions for universal gripping are emerging. These grasping systems can enable the handling of wide varieties of shapes, with gripping forces varying with grasped geometries. For the efficient usage of handling systems, precise offline and online prediction models for resulting grasping forces for different objects are necessary. In previous research, a flexible vacuum-based granular gripper was developed, for which no option for predicting gripping forces is currently available. Various gripping force prediction methodologies within the current state of the art are examined and evaluated. For an assessment of grasping forces of previously untested objects for the examined gripper with limited data and low computational effort, two methodologies are proposed. An analytical, 2D-geometry-derived gripper-specific metric for geometries is compared to a methodology based on similarities of objects to a small existing dataset. The applicability and prediction quality for different object types is analyzed through validation experiments. Gripping force estimations are possible with both methodologies, with individual weaknesses towards geometric features such as air permeabilities. With further development, robust predictions of gripping forces could be achieved for a wide range of unknown object geometries with limited experimental effort.
DNA Sequence variability analysis of the gD and the UL36 genes of Bovine herpesvirus-1 isolated from field cases in Indonesia

ABSTRACT To investigate the genotype of Bovine herpesvirus-1 (BHV-1) isolated in Indonesia (n = 10), the DNA sequences of fragments of two genes, including the middle third of the gD gene and the downstream end of UL36, were determined using nested PCR. All the samples were classified as BHV-1.2 according to the deduced amino acid sequence of gD. On the other hand, analysis of the nucleotide sequence of UL36 indicated the presence of insertions or deletions (indels) compared to reference sequences and each other, which indels made more diverse than in gD sequence, and the classification of BHV-1 subtype based on the deduced amino acid sequence of UL36 differed from that obtained using the gD protein sequence. These results suggested that while the gD sequence analysis was suited for rough classification of BHV-1 subtype, the UL36 sequence permitted detection of BHV-1 subtype polymorphisms.
THE BRACKEN FERN (PTERIDIUM ARACHNOIDEUM (KAULF.) MAXON) DILEMMA IN THE ANDES OF SOUTHERN ECUADOR

Bracken fern (Pteridium aquilinum (L.) Kuhn) is one of the world's most powerful weeds, especially in agricul- tural areas. Its vigor and resistance to any kind of non-polluting pest control result from its extensive rhizome system. Gro- wth of this rhizome system is strongly promoted by fire. As elsewhere in the tropics, farmers in the Andes of southern Ecuador make extensive use of fire to convert primary forest into arable land and to maintain their pastures. This com- munication addresses, from a phytosociological viewpoint, the ecological problems arising from the use of fire as an agri- cultural tool in the presence of the extremely aggressive and fire-tolerant bracken fern Pteridium arachnoideum. Repeated burning of the pastureland weakens the competitive strength of the most important pasture grass Setaria sphacelata, whi- le the competitive strength of bracken increases. Pastures are finally abandoned when Pteridium has become completely predominant. Wind-dispersed seeds of several weedy Asteraceae and Melastomataceae species germinate under the canopy of the bracken leaves and, due to the steepness of the slopes, the seedlings receive sufficient light for further growth. The majority of these species are bushes that finally overtop the bracken leaves and can successfully compete with the shade intolerant fern. A vegetation composed of dense patches of Pteridium interspersed with individual bushes develops, which, because of the immense seed production of the bushes and the vigor of the bracken, is very stable and appears to be a long- lasting and even at times the final successional stage. Since natural regeneration of the indigenous forest is very unlikely in these areas, reforestation may be the only way out of the dilemma caused by the extensive use of fire and the fire-tolerance of bracken. Accepted 28 January 2003.
Compensation, working environment, and employee performance: A study in one of the municipal water supply companies in West Java

Along with the increasingly advanced era, human resources are vital for small and large companies because their position drives all activities to achieve their goals. Similarly, the municipal water supply company also needs employees to serve society well. Therefore, some roles, like compensation and working environment, are necessary to attain this situation. Based on this circumstance, this study examines their impact on employee performance. Moreover, to reach this purpose, this study distributes the questionnaire to the 113 municipal water supply employees in one of the West Java regencies as the samples, taken by simple random sampling technique. Also, a survey is employed to collect data. The regression model and t-statistic are utilized to analyze the data and examine the proposed hypotheses. In conclusion, this study declares that their performance is positively affected by the work environment. Conversely, it is not influenced by compensation.
Influence of Nε-Lysine Acetylation on the Formation of Protein Aggregates and Antibiotic Persistence in E. coli

Numerous studies indicate that reversible Nε-lysine acetylation in bacteria may play a key role in the regulation of metabolic processes, transcription and translation, biofilm formation, virulence, and drug resistance. Using appropriate mutant strains deficient in non-enzymatic acetylation and enzymatic acetylation or deacetylation pathways, we investigated the influence of protein acetylation on cell viability, protein aggregation, and persister formation in Escherichia coli. Lysine acetylation was found to increase protein aggregation and cell viability under the late stationary phase. Moreover, increased lysine acetylation stimulated the formation of persisters. These results suggest that acetylation-dependent aggregation may improve the survival of bacteria under adverse conditions (such as the late stationary phase) and during antibiotic treatment. Further experiments revealed that acetylation-favorable conditions may increase persister formation in Klebsiella pneumoniae clinical isolate. However, the exact mechanisms underlying the relationship between acetylation and persistence in this pathogen remain to be elucidated.