Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of dietary copper intake on blood lipids in women of childbearing age and the potential role of gut microbiota

Background Copper (Cu) is a vital trace element involved in numerous physiological processes, including glycolysis and lipid metabolism. Imbalances in Cu homeostasis can contribute to various diseases. However, current research on the impact of Cu on lipid metabolism has yielded inconsistent findings. Moreover, studies investigating the effects of dietary Cu intake on blood lipids among women of childbearing age are rare. Understanding of this relationship could enhance lipid management, given that most women obtain Cu through their diet. Additionally, the gut microbiota may play a role in this process. This study aims to investigate the effects of dietary Cu intake on blood lipids in women of childbearing age and to analyze the role of gut microbiota in this process. Methods This study utilized data from the National Health and Nutrition Examination Survey (NHANES) to conduct a preliminary analysis of the correlation between dietary Cu levels and blood lipid indicators in women of childbearing age. Subsequently, an on-site research was conducted to further investigate this relationship, followed by animal experiments to verify the effect of different Cu doses on blood lipid levels. Multiple linear regression models, ANOVA, XGBOOST were employed to analyze the impact of Cu on blood lipids and the role of intestinal microbiota in this process. Results In the population study, the NHANES results were consistent with on-site findings. The TG, and TC levels in women with childbearing were increased with higher dietary Cu intake. Animal experiments have shown that as Cu intake increases, TC levels increase. Furthermore, when the Cu intake reached 8 mg/day (the recommended dietary Cu intake limit of China, RDI), the TG levels in the research animals decrease, alongside a reduction in the abundance of Weissella cibaria (probiotics related to lipid metabolism), and the levels of LPS and IL-6 increase. Conclusion The blood lipid levels of women of childbearing age increase with higher dietary Cu intake. RDI of 8 mg/day for women of childbearing age in China may need to be appropriately reduced. Regulating the gut microbiota, especially by increasing the abundance of Weissella cibaria may be an effective intervention for blood lipids.
Effects of Genotype on Pig Carcass, Meat Quality and Consumer Sensory Evaluation of Loins and Bellies

The objective of the study was to compare carcass and meat quality among Lithuanian White, Lithuanian Indigenous Wattle and conventional hybrids as well as consumer sensory evaluations. The pigs were slaughtered at a live weight of approximately 95–100 kg. After 24 h of slaughter, carcasses were evaluated and sampled for the analysis of meat quality traits of loins and consumer evaluation of cooked loins and baked bellies. The pigs of both Lithuanian breeds had higher backfat thickness and depth of underbelly but lower loin area compared with hybrids. However, more fatty local breeds had higher intramuscular fat content but lower cholesterol content than hybrids. The loins from local pigs displayed higher pH and colour with lower lightness and yellowness but higher redness and also lower cooking loss, shear force and hardness than conventional hybrids. Pork from lean hybrids had a higher proportion of polyunsaturated fatty acids and more favourable lipid quality indices such as atherogenic (AI) and thrombogenic (TI) indices and the hypocholesterolemic/hypercholesterolemic (h/H) ratio; however, the peroxidisability index (PI) and iodine value (IV) were less favourable compared with local pigs. Consumers evaluated cooked loins and baked bellies. The loins from local breeds scored higher in juiciness, taste and overall acceptability compared with conventional hybrids. However, a higher overall acceptability was observed for the lean bellies of hybrids. The results can be used to increase pork consumption choices.
Un nuevo metodo de analisis termico: el analisis termico a velocidad de transformacion controlada (ATVC). II

Description des principes fondamentaux et evolution de la nouvelle technique. Dans le controle des phenomenes de transport de masse et d'energie, elle permet une plus grande efficacite que la thermogravimetrie ou l'A.T. D. Les donnees obtenues sont donc plus representatives de la reaction chimique
Autosomal Dominant Retinitis Pigmentosa Secondary to TOPORS Mutations: A Report of a Novel Mutation and Clinical Findings

Purpose: Mutations in Topoisomerase I–binding RS protein (TOPORS) have been previously documented and have been described to result in pathological autosomal dominant retinitis pigmentosa (adRP). In our study, we describe the various genotypes and clinical/phenotypic manifestations of TOPORS-related mutations of our unique patient population in Rural Appalachia. Methods: The medical records of 416 patients with inherited retinal disease at the West Virginia University Eye Institute who had undergone genetic testing between the years of 2015–2022 were reviewed. Patients found to have pathologic RP and mutations related to TOPORS were then analyzed. Results: In total, 7 patients (ages 12–70) were identified amongst three unique families. All patients were female in our study. The average follow-up period was 7.7 years. A mother (70 yr) and daughter (51 yr) had a novel heterozygous nonsense point mutation in TOPORS c.2431C > T, p.Gln811X (Exon 3) that led to premature termination of the desired protein resulting in early onset vision loss, cataract formation, and visual field restriction. The mother developed a full-thickness macular hole which was successfully repaired. Five other patients were found to have previously described TOPORS mutations. Visual field loss was progressive with age in both cohorts. Conclusions: Seven patients at our institution were identified to have mutations in TOPORS resulting in autosomal dominant retinitis pigmentosa. Two patients were found to have novel truncating mutations in the TOPORS gene resulting in profound night blindness and visual field loss, recurrent macular edema, and in one individual, epiretinal membrane formation leading to a macular hole which was able to be successfully repaired.
Marine source signature estimation with dual near-field hydrophones

We derive marine seismic signatures using twice the usual number of near-field hydrophones, following the proposition of Parkes and Hatton (1986), in which the notional sources and their virtual image are solved for directly. This removes the need to assume a value for the free-surface reflectivity and amounts to a separation of the up-going and down-going wave-field in the vicinity of the source array. A test sequence of near-field records and seismic data were acquired. Inspection of the near-field recordings revealed clipping of large negative amplitudes, probably related to cavitation in the water, explaining an observed reduction in amplitude of the ghost in the derived signature. We evaluated the signatures via processing of the seismic data and compared them against signatures derived from a single NFH per source element, using a parametric ghost model (Hargreaves et al., 2016).
Can Tax Avoidance Improve The Positive Relationship Between Intellectual Capital And Firm Value?

This study examines the effect of intellectual capital on firm value with tax avoidance as moderation in health sector companies listed on the Indonesia Stock Exchange during the COVID-19 pandemic. CTTOR is employed to find the level of tax avoidance, VAIC is used to find the value of intellectual capital, and Tobin's Q is used to find the firm value. The data used is company financial statement data from 2020 to 2022 using multiple linear regression analysis methods. The type of data is cross-section data and ordinary least squares (OLS) estimation technique. The sample was determined using a purposive sampling technique with a total research sample of 43 data. This study concluded that intellectual capital does not affect firm value. However, after moderation with tax avoidance, the interaction between intellectual capital and tax avoidance has a negative effect on firm value. Therefore, tax avoidance can moderate the effect of intellectual capital on firm value by reducing the negative effect of intellectual capital on firm value during the COVID-19 pandemic. The results of this study can be additional information for the Indonesian Capital Market Supervisory Authority (OJK) and the Tax Authority (DGT) in making rules regarding tax avoidance. OJK can also make policies regarding reporting the company's intellectual capital in one account to make it easier for novice investors to understand. DGT can utilize this research to evaluate corporate tax avoidance.
Psychological Mechanisms in Social Cognition Research: Taking Social Power Area as an Example

: This article discusses the methods and approaches used to examine psychological processes in the field of social cognition research, with a specific focus on the area of social power. Social cognition refers to the mental processes involved in perceiving, interpreting, and understanding social information. Understanding how individuals perceive and respond to power dynamics within social interactions is crucial for comprehending various social phenomena. The article highlights the importance of examining psychological processes in social cognition research and provides insights into the specific example of social power. We introduced three types of methods to examine psychological processes at the level of experiment design proposed by Spencer, Zanna and Fong, and summarized situations of using these three designs in past. It discusses different experimental designs, measures, and paradigms commonly employed to investigate social power and its influence on cognitive processes. Additionally, it emphasizes the need for interdisciplinary collaboration and the integration of various research methods to gain a comprehensive understanding of social cognition and its underlying psychological mechanisms. Overall, this article serves as a guide for researchers interested in studying psychological processes within the context of social cognition, particularly in relation to social power dynamics.
Role of low-density lipoprotein electronegativity and sexual dimorphism in contributing early ventricular tachyarrhythmias following ST-elevation myocardial infarction

Background Early ventricular tachycardia/fibrillation (VT/VF) in patients with ST-elevation myocardial infarction (STEMI) has higher morbidity and mortality. This study examines gender-differentiated risk factors and underlying mechanisms for early onset VT/VF in STEMI. Methods We analyzed data from 2,964 consecutive STEMI patients between January 1, 2008 and December 31, 2021. Early VT/VF was defined as occurrence of spontaneous VT/VF of ≥30 s or requirement of immediate cardioversion/defibrillation within the first 48 h after symptoms. An ex vivo ischemic-reperfusion experiments were conducted in 8-week-old ApoE−/− mice fed a high-fat diet to explore the underlying mechanisms of early VT/VF. Results In 255 of out 2,964 STEMI patients who experienced early VT/VF, the age was younger (58.6 ± 13.8 vs. 61.0 ± 13.0 years old, P = 0.008) with a male predominance. The plasma levels of L5, the most electronegative subclass of low-density lipoprotein, was higher in early VT/VF patients compared to those without early VT/VF (n = 21, L5: 14.1 ± 22.6% vs. n = 46, L5: 4.3 ± 9.9%, P = 0.016). In the experimental setup, all male mice (n = 4) developed VT/VF post sham operation, whereas no such incidence was observed in the female mice (n = 3). Significantly, male mice exhibited considerably slower cardiac conduction velocity as compared to their female counterparts in whole heart preparations (25.01 ± 0.93 cm/s vs.42.32 ± 5.70 cm/s, P < 0.001), despite analogous action potential durations. Furthermore, isolated ventricular myocytes from male mice showed a distinctly lower sodium current density (−29.20 ± 3.04 pA/pF, n = 6) in comparison to female mice (−114.05 ± 6.41 pA/pF, n = 6, P < 0.001). This decreased sodium current density was paralleled by a reduced membrane expression of Nav1.5 protein (0.38 ± 0.06 vs. 0.89 ± 0.09 A.U., P < 0.001) and increased cytosolic Nav1.5 levels (0.59 ± 0.06 vs. 0.29 ± 0.04 A.U., P = 0.001) in male mice. Furthermore, it was observed that the overall expressions of sorting nexin 27 (SNX27) and vacuolar protein sorting 26 (VPS26) were significantly diminished in male mice as compared to female littermates (0.91 ± 0.15 vs. 1.70 ± 0.28, P = 0.02 and 0.74 ± 0.09 vs. 1.57 ± 0.13, P < 0.01, respectively). Conclusions Our findings reveal that male STEMI patients with early VT/VF are associated with elevated L5 levels. The gender-based discrepancy in early VT/VF predisposition might be due to compromised sodium channel trafficking, possibly linked with increased LDL electronegativity.
Nutrient Variability Mapping and Demarcating Management Zones by Employing Fuzzy Clustering in Southern Coastal Region of Tamil Nadu, India

Precise nutrient management for enhancing crop yield is possible through delineating soil management zones. Generally, the fertilizer recommendations followed use a blanket application for a larger area without considering the soil spatial variability. This may lead to low fertilizer application in pockets of less nutrient content and vice versa. Therefore, this study aims to develop soil management zones (MZs) adopting geostatistical and fuzzy clustering techniques in the Alwarthirunagiri block of the Thoothukudi district in Southern India. One hundred and seventy-one surface samples were collected from a study area of 2760 ha. The collected soils were processed and characterized by available macronutrients and micronutrients. The coefficient of variation of the soils varied from low (9.72%) to high (74.60%). Ordinary kriging and semivariogram analysis showed wide variation in the soil characteristics within the study site, with a spatial dependence ranging from moderate to strong. Four management zones were demarcated based on fuzzy performance index and normalized classification entropy using PCA and fuzzy K-means clustering. The study results indicated that the soil properties differed significantly under different management zones and provided potential site-specific fertilizer management options. The management zone map could be useful to the farmers to adopt precise management of nutrients for different zones.
Crustal thickness estimates for Baja California, Sonora, and Sinaloa, Mexico, using disperse surface waves

[1] Dispersed surface waves of regional events recorded at Network of Autonomously Recording Seismographs (NARS)-Baja and Red Sismica de Banda Ancha (RESBAN) networks located over the Baja California Peninsula, Sonora, and Sinaloa, Mexico, were used to estimate shear wave elastic models and crustal thickness. We analyzed fundamental modes of surface waves with period between 10 and 40 s. Multiple filter analysis and the inversion method described by Herrmann and Ammon (2003) was used. Crustal thickness estimates for the Peninsular Ranges of Northern Baja California agree with those obtained by previous studies in the Peninsular Ranges of Northern Baja California. We analyzed dispersion of surface waves with northwest-southeast travel paths along the east and west sides of the Baja California Peninsula as well as a northwest-southeast travel path along the western sides of the Mexican states of Sonora and Sinaloa. It was found that the crustal structure east of the Baja California Peninsula is similar to the structure of Sonora and Sinaloa. The correlation between those two structures suggests dextral offset of the order of 275 ± 25 km if we consider Baja California Peninsula as a rigid body moving toward the northwest relative to the North America plate. This displacement between the structures is in agreement with the displacement determined by the dating of Miocene deposits located in San Felipe on the Baja California Peninsula (Pacific plate), and Isle Tiburon located west of Sonora (North America plate).
Structural elements of the southern Thomson Orogen (Australian Tasmanides): a tale of megafolds

Abstract Multi-scale, multi-method integration of geological constraints, with new interpretations of potential field data and seismic reflection data, has resulted in a comprehensive structural interpretation of the southern Thomson Orogen, eastern Australia. The interpretation reveals ∼50 major faults and shear zones, many of which can be traced for several hundred kilometres. The interpretation suggests that the southern Thomson Orogen can be subdivided into several structural domains that can be distinguished by differences in: (i) spatial orientation, (ii) geographic distribution, and (iii) partly the timing of major faults, but also to varying degrees by (iv) the evolution and spatial orientation of other structural elements, such as folds, minor faults and fractures, (v) broader lithological trends, (vi) stratigraphy, and (vii) structural style. The two largest domains are the Western Structural Domain that contains numerous faults and shear zones, and the fold-dominated Eastern Structural Domain, which is more strongly affected by late- to post-Devonian thrusting than the Western Structural Domain. Notwithstanding their differences, the domains can be integrated into a coherent structural model for the southern Thomson Orogen, which suggests that the area represents a set of megafolds or oroclines, which may have formed during the Bindian Orogeny.
Influence of Mountain Spruce Forest Dieback on Snow Accumulation and Melt

Abstract Large-scale forest dieback was reported in recent decades in many parts of the world. In Slovakia, the most endangered species is Norway spruce (Picea Abies). Spruce dieback affects also indigenous mountain forests. We analysed changes in snow cover characteristics in the disturbed spruce forest representing the tree line zone (1420 m a.s.l.) in the Western Tatra Mountains, Slovakia, in five winter seasons 2013-2017. Snow depth, density and water equivalent (SWE) were measured biweekly (10-12 times per winter) at four sites representing the living forest (Living), disturbed forest with dead trees (Dead), forest opening (Open) and large open area outside the forest (Meadow). The data confirmed statistically significant differences in snow depth between the living and disturbed forest. These differences increased since the third winter after forest dieback. The differences in snow density between the disturbed and living forest were in most cases not significant. Variability of snow density expressed by coefficient of variation was approximately half that of the snow depth. Forest dieback resulted in a significant increase (about 25%) of the water amount stored in the snow while the snowmelt characteristics (snowmelt beginning and time of snow disappearance) did not change much. Average SWE calculated for all measurements conducted during five winters increased in the sequence Living < Dead < Meadow < Open. SWE variability expressed by the coefficient of variation increased in the opposite order.
Taphonomy of benthic foraminiferal tests from the Jurujuba Sound, Guanabara Bay, Rio de Janeiro, Brazil

1Instituto Oceanográfico da Universidade de São Paulo/USP, São Paulo, SP, Brazil pkfouri@io.usp. br 2Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho/UNESP, Botucatu, SP, Brazil 3Instituto de Geociências, Programa de Pós-graduação, GSA, IGc/USP, Universidade de São Paulo/USP, SP, Brazil 4Delaware Geological Survey, University of Delaware, Newark, DE, U.S.A. 5Universidade Cruzeiro do Sul/UNICSUL, São Paulo, SP, Brazil
Method for early ignition detection based on the sampling dispersion of dangerous parameter

The object of the study is the selective dispersion of dangerous parameters of the gas environment during material fires. The practical importance of research consists in using the difference of sample dispersions of dangerous parameters of the gas environment on the intervals of absence and presence of ignition of materials for detection of ignition. The theoretical substantiation of the method of detecting fires in premises based on sample dispersions of current measurements of an arbitrary dangerous parameter of the gas environment, corresponding to the general populations of reliable absence and presence of fire, has been carried out. The method, at a given level of significance, determines the unbiased uniformly most powerful fire detection rule. This makes it possible to determine how much differences in sample variances are significant with a given level of significance and are caused by ignition or are random factors. Laboratory experiments were conducted to verify the proposed method. It was established that the influence of ignition on the value of the difference in the sample dispersion at the corresponding intervals of monitoring the carbon monoxide concentration, smoke density, and temperature of the gaseous environment of the laboratory chamber is different and depends on the type of ignition material. At the same time, the minimum difference of the sample dispersions is characteristic for observing the smoke density for all the studied materials. However, early detection of ignition of alcohol, paper, wood, and textiles when observing the smoke density is carried out when the threshold is exceeded by 9.01, 5.31, 2.13 and 2.55 times, respectively. It is shown that the method of early detection of fires, which is based on the detection of significant differences in sample dispersions of data from the relevant general populations
Ozone applied to the nutrient solution and its impact on red chard baby leaves yield

Safety of fresh-cut products is largely affected by the microbial load of raw material. In this sense, a hydroponic production system allows to reduce microbial contamination, as long as the quality of the used water on the production system is ensured. This can be achieved through water sanitation. Moreover, treatments used to sanitize the nutrient solution can have an effect on its composition affecting subsequently the crop yields, especially if a strong oxidizing agent such as ozone (O3) is used. In this work the effect of periodically gaseous O3 application on nutrient solution composition and its impact on the yield of red chard baby leaves was evaluated. O3 applications were performed every two days of culture at doses of 0 (control), 0.50, 1.0 and 2.0 mg L-1 for 3 min. Three harvests were performed on days 10, 17 and 26 after transplant. Macroand micronutrients, dissolved oxygen (DO) and electrical conductivity (EC) of the nutrient solution were determined. Red chard yield was evaluated by fresh mass production and leaf area. Nutrient solution macronutrients were not affected by O3, while micronutrients such as Fe and Mn contents decreased by 88 and 40%, respectively, on 0.50 mg L-1 dose. DO reached 2.0 mg L-1 increases up to 50% more than the control in each application. EC was not significantly affected by O3 applications (ranges 2.46 and 2.82 dS m-1 at 25°C). However, all O3 treatments increased red chard yield compared to the control. The dose of 0.50 mg L-1 produced the highest fresh matter and leaf area (53 and 22% more, respectively, than the control). It is concluded that O3 applications to hydroponic red chard culture increase yield even though the availability some micronutrients as Fe and Mn could be affected.