Miracle-dz/UniFAR-FTUs huggingface dataset:
The Influence of Illness Perception, Anxiety and Depression Disorders on Students Mental Health during COVID-19 Outbreak in Pakistan: A Web-Based Cross-Sectional Survey

Background: Since the emergence of a coronavirus disease (2019-nCoV) in December 2019, the whole world is in a state of chaos. Isolation strategy with quarantine is a useful model in controlling transmission and rapid spread. As a result, people remained at homes and disrupted their outside daily activities. It led to the closure of educational institutes, which is a source of many students to cope with numerous personal and familial issues. This study focuses on exploring the relationships and potential mediational pathways between mental health problems, illness perception, anxiety, and depression disorders.Method: The study incorporated snowball sampling techniques through a cross-sectional, web-based survey and recruited 500 students from different public and private universities from twin cities, Rawalpindi, and Islamabad from March 23 to April 15, 2020, during the coronavirus outbreak lockdown. The study used four instruments, Beck Depression Scale, Beck Anxiety Inventory, Revised Illness Perception Questionnaire, and The Warwick-Edinburgh Mental Well-being Scale for assessing depression, anxiety, illness perception, and mental health disorders.Results: The findings indicated normal (43.2%) mild (20.5%), moderate (13.6%), and severe (22.7%) level of anxiety prevalence in students. Results specified a normal (65.9%), mild (9.10%), moderate (9.12%), and severe (15.90%) depression prevalence, and findings stipulated that anxiety disorder prevalence was higher than the depression disorder. The correlational results specified a negative and significant relationship between mental health, illness perception, anxiety, and depression symptoms. The multiple regression analysis stated that anxiety and depression disorders mediated the relationship between mental health and present illness perception. The perception of illness exhibited a relation to depression and anxiety disorders.Conclusion: The study proposed a model to address mental health problems during the lockdown. The (2019-nCoV) illness perception developed mental disorders, including anxiety and depression, which has declined individuals' mental health. There is an urgent need for ongoing clinical examination and management to address psychological disorders, and findings suggest assessing mental health to combatting the pandemic worldwide. Findings recommend developing strategies to promote mental healthcare facilities during COVID-19 wide-ranging disasters. These results highlight the impending importance of devising strategies to treat mental health problems.
Comparison of the Attitudes of Nurses and Physicians toward Palliative Care in Neonatal Intensive Care Units

Purpose This study aimed to compare the attitudes of nurses and physicians toward neonatal palliative care and identify the barriers to and facilitators of neonatal palliative care, with the goal of improving palliative care for infants in neonatal intensive care units (NICUs). Methods This cross-sectional study analyzed data from the NICUs of seven general hospitals with 112 nurses and 52 physicians participating. Data were collected using the Neonatal Palliative Care Attitude Scale questionnaire. Results Only 12.5% of nurses and 11.5% of physicians reported that they had sufficient education in neonatal palliative care. In contrast, 89.3% of the nurses and 84.6% of the physicians reported that they needed further education. The common facilitators for both nurses and physicians were 1) agreement by all members of the department regarding the provision of palliative care and 2) informing parents about palliative care options. The common barriers for both nurses and physicians were 1) policies or guidelines supporting palliative care were not available, 2) counseling was not available, 3) technological imperatives, and 4) parental demands for continuing life support. Insufficient resources, staff, and time were also identified as barriers for nurses, whereas these were not identified as barriers for physicians. Conclusion It is necessary to develop hospital or national guidelines and educational programs on neonatal palliative care, and it is equally necessary to spread social awareness of the importance of neonatal palliative care.
Soil Arching of Piled Embankment in Equal Settlement Pattern: A Discrete Element Analysis

Soil arching, which occurs in the piled embankments, plays an important role in stress redistribution between the relatively soft subsoil and the stiffer piles. The formation of the soil arching depends on the differential settlement of the embankment fill above the pile and the subsoil. The soil arching effect is barely investigated in the literature from the perspective of differential settlement of piles and soils. Based on the discrete element method (DEM), this paper develops a classic trapdoor test model to investigate the differential settlement in piled embankment during the downward movement of the trapdoor, and to explore the formation mechanism of soil arching in equal settlement pattern by changing the width of the pile cap and the height of the embankment. Due to symmetry, only one section of the laboratory test model is simulated herein. It was found that the soil arching formed under the equal settlement pattern remained unchanged after a certain degree of development, and the height of the equal settlement did not change at 0.7(s-a), where s is the pile spacing, and a is the width of the pile cap. The height of the embankment (H) and the width of the pile cap (a) have a significant influence on the formation of the equal settlement pattern when the width of the trapdoor is kept constant. Both the decrease in “H” and the increase in “a” facilitate the differential settlement of the soil between the piles and the pile-soil, enabling the slip surface to develop upward gradually, thereby hindering the formation of the equal settlement pattern.
Global Dynamics and Implications of an HBV Model with Proliferating Infected Hepatocytes

Chronic hepatitis B (HBV) infection is a major cause of human suffering, and a number of mathematical models have examined the within-host dynamics of the disease. Most previous models assumed that infected hepatocytes do not proliferate; however, the effect of HBV infection on hepatocyte proliferation is controversial, with conflicting data showing both induction and inhibition of proliferation. With a family of ordinary differential equation (ODE) models, we explored the dynamical impact of proliferation among HBV-infected hepatocytes. Here, we show that infected hepatocyte proliferation in this class of models generates a threshold that divides the dynamics into two categories. Sufficiently compromised proliferation in infected cells produces complex dynamics characterized by oscillating viral loads, whereas higher proliferation generates straightforward dynamics that always results in chronic infection, sometimes with liver failure. A global stability result of the liver failure state was included as it is unique to this class of models. Finally, the model analysis motivated a testable biological hypothesis: Healthy hepatocytes are present in chronic HBV infection if and only if the proliferation of infected hepatocytes is severely impaired.
Development and Validation of a Nomogram for Predicting Overall Survival in Patients with Second Primary Small Cell Lung Cancer After Non-Small Cell Lung Cancer: A SEER-Based Study

Background Non-small cell lung cancer (NSCLC) survivors are at an increased risk of developing second primary malignancies, such as small cell lung cancer. This paper sought to establish a prognostic nomogram to assess overall survival (OS) in patients with second primary small cell lung cancer (SPSCLC) after NSCLC. Methods 420 patients who developed SPSCLC after NSCLC were randomly split into the training and validation groups. A nomogram was established by stepwise regression. Area under the curve (AUC) and calibration plots were applied to assess the prognostic performance of the nomogram. Concordance index (C-index), integrated discrimination improvement (IDI), net reclassification index (NRI) and decision curve analysis (DCA) were performed to compare the nomogram with the American Joint Committee on Cancer (AJCC) 8th staging system. Survival risk classification was constructed based on the nomogram. Results Five variables were chosen to construct the nomogram. The AUC showed that it had a satisfactory discrimination ability. All calibration plots displayed good concordance between nomogram and observation. The C-index, IDI, NRI and DCA showed the nomogram was superior to the AJCC 8th staging system. The Kaplan-Meier curves suggested huge differences in prognosis among the three risk groups. Conclusion This study build a nomogram and risk stratification system for predicting probabilities of OS in patients with SPSCLC after NSCLC, which can help clinicians in individualized survival assessment and treatment decisions.
Potential Clinical Utility of a Targeted Circulating Tumor DNA Assay in Esophageal Adenocarcinoma

Objective: To explore the clinical utility of circulating tumor DNA (ctDNA) in esophageal adenocarcinoma (EAC) by developing a cost-effective and rapid technique utilising targeted amplicon sequencing. Summary of background data: Emerging evidence suggests that levels of ctDNA in the blood can be used to monitor treatment response and in the detection of disease recurrence in various cancer types. Current staging modalities for EAC such as computerised tomography of the chest/abdomen/pelvis (CT) and positron emission tomography (PET) do not reliably detect occult micro-metastatic disease, the presence of which signifies a poor prognosis. After curative-intent treatment, some patients are still at high risk of recurrent disease, and there is no widely accepted optimal surveillance tool for patients with EAC. Methods: Sixty-two patients with EAC were investigated for the presence of ctDNA using a tumor-informed approach. We designed a custom targeted amplicon sequencing panel of target specific primers covering mutational foci in 9 of the most commonly mutated genes in EAC. Serial blood samples were taken before and after neoadjuvant treatment (NAT), and during surveillance. Results: Somatic mutations were detected in pre-treatment biopsy samples of 55 out of 62 (89%) EAC patients. Mutations in TP53 (80%) were the most common. Out of these 55 patients, 20 (36%) had detectable ctDNA at baseline. The majority (90%) of patients with detectable ctDNA had either locally advanced tumors, nodal involvement or metastatic disease. In patients with locally advanced tumors, disease free survival (DFS) was more accurately stratified using pre-treatment ctDNA status [HR 4.34 (95% CI 0.93–20.21); P = 0.05] compared to nodal status on PET-CT. In an exploratory subgroup analysis, patients who are node negative but ctDNA positive have inferior DFS [HR 11.71 (95% CI 1.16-118.80) P = 0.04]. In blood samples taken before and following NAT, clearance of ctDNA after NAT was associated with a favourable response to treatment. Furthermore, patients who are ctDNA positive during post-treatment surveillance are at high risk of relapse. Conclusions: Our study shows that ctDNA has potential to provide additional prognostication over conventional staging investigation such as CT and PET. It may also have clinical utility in the assessment of response to NAT and as a biomarker for the surveillance of recurrent disease.
Is Face Age Mapped Asymmetrically onto Space? Insights from a SNARC-like Task

The magnitude associated with a stimulus can be spatially connoted, with relatively smaller and larger magnitudes that would be represented on the left and on the right side of space, respectively. According to recent evidence, this space–magnitude association could reflect specific brain asymmetries. In this study, we explored whether such an association can also emerge for face age, assuming that responders should represent relatively younger and older adult faces on the left and on the right, respectively. A sample of young adults performed a speeded binary classification task aimed at categorising the age of a centrally placed adult face stimulus as either younger or older than the age of a reference face. A left-side and a right-side response key were used to collect manual responses. Overall, older faces were categorised faster than younger faces, and response latencies decreased with the absolute difference between the age of the target stimulus and the age of the reference, in line with a distance effect. However, no evidence of a left-to-right spatial representation of face age emerged. Taken together, these results suggest that face age is mapped onto space differently from other magnitudes.
Wild Boar in Flanders, Belgium: (Dis)agreements Between Key Stakeholders on Wild Boar Management Objectives, Actions, and Legal Provisions

Wild boar (Sus scrofa) reappeared in Flanders, Belgium in 2006 after more than half a century of absence. Besides being a native and highly valued game species in Europe, wild boar are also known to be responsible for car collisions, crop damage, disease transmission, and ecological damage at high densities. The management of wild boar therefore seeks to balance these positive and negative impacts. Given the highly fragmented landscape in Flanders and its multifunctional use, coexistence with wild boar is only possible through integrated management involving relevant stakeholder groups. However, to be successful, this requires that the management objectives, the overall wild boar policy of the Flemish authorities, and management actions are supported by the stakeholders. To assess the support for the current management, we conducted a survey among members of the 3 key stakeholder groups: farmers, hunters, and conservationists. Our survey assessed the importance stakeholders attribute to different management objectives, their support for the current legal provisions, and how desirable the different stakeholder groups considered possible management actions. The potential for conflict index was used to analyze the (dis)agreement between and within stakeholder groups. Reducing or preventing crop damage and the risk for car accidents are indicated as being the most important management objectives by all 3 stakeholder groups. Stakeholder groups differ strongly in their support for the current legal provisions. Those stakeholders that have to implement the legal provisions or are mostly affected by these laws are less supportive than others. The desirability of the possible management actions strongly varied according to the different stakeholder groups. Contrary to other studies, the desirability of a possible management action was hardly influenced by the management objective it tried to achieve.
Does The Efficient Market Theory In The Weak Form Exist? Evidence From Indonesia

In the weak-form market efficiency theory, investors cannot predict the movement of all prices because of randomness. This circumstance happens because of a quick market reaction to new information. Conversely, suppose the market is not efficient in this shape; in that case, the investors can obtain an abnormal return. One of the reasons is the thin market, where many inactive stocks to be traded are available. Based on these issues, this research intends to examine this theory by employing runs testing on the daily returns of the Indonesia Composite Index (ICI) between January 2014 and December 2018 for each year and a whole. Once performing this test, this research demonstrates that the daily returns of the ICI are random for both situations. By denoting these facts, this research concludes that the capital market in Indonesia is efficient in a weak form and experiences a decrease in the thin level, reflected by the escalation in trading frequency, volume, and value, as well as the number of dynamic shares transacted. This research suggests that investors without sufficient information should utilize the service of the securities analysts to select the stocks they buy and sell to get the capital gain. Keywords – an efficient market in the weak form; market index return; runs test; thin market
Frailty among chronic kidney disease patients on the kidney transplant waiting list: the sex–frailty paradox

ABSTRACT Background Frailty is defined as decreased physiologic reserve and resistance to stressors that predisposes patients towards poor health results. Its prevalence in chronic kidney disease (CKD) patients who are kidney transplant (KT) candidates is high. Frailty is associated with a higher rate of complications and mortality after transplant. It is unknown whether frailty phenotype differs depending on sex in this population. Methods This was a prospective longitudinal study of 455 KT candidates evaluated for frailty by physical frailty phenotype at the time of inclusion on the KT waiting list. Pre-frailty was defined as the presence of two criteria and frailty as three or more criteria. Univariate and multivariate analyses searched for associations of frailty status, frailty components and gender differences. Results Thirty percent of the total cohort resulted to be pre-frail (20%) or frail (10.3%), but disparities were observed between sexes, with 22.5% of men and 47.2% of women falling into one of these categories. Among frailty criteria, women presented with a higher percentage of exhaustion (39.6% versus 17%) and slowness (22.2% versus 9.6%) compared with men. Comorbidity burden was higher among frail men, whereas social factors were poorer between frail women. Disability was common among those patients who were frail, both men and women. Conclusions Frailty is twice as frequent in advanced CKD women as men. Frailty criteria distribution and phenotype seem to differ among sexes, which might have implications in terms of specific and individualized interventions to improve their status before transplantation.
Simulation of Hydrogen-Air-Diluents Mixture Combustion in an Acceleration Tube with FlameFoam Solver

During a severe accident in a nuclear power plant, hydrogen can be generated, leading to risks of possible deflagration and containment integrity failure. To manage severe accidents, great experimental, analytical, and benchmarking efforts are being made to understand combustible gas distribution, deflagration, and detonation processes. In one of the benchmarks—SARNET H2—flame acceleration due to obstacle-induced turbulence was investigated in the ENACCEF facility. The turbulent combustion problem is overly complex because it involves coupling between fluid dynamics, mass/heat transfer, and chemistry. There are still unknowns in understanding the mechanisms of turbulent flame propagation, therefore many methods in interpreting combustion and turbulent speed are present. Based on SARNET H2 benchmark results, a two-dimensional computational fluid dynamics simulation of turbulent hydrogen flame propagation in the ENACCEF facility was performed. Four combustible mixtures with different diluents concentrations were considered—13% H2 and 0%/10%/20%/30% of diluents in air. The aim of this numerical simulation was to validate the custom-built turbulent combustion OpenFOAM solver based on the progress variable model—flameFoam. Furthermore, another objective was to perform parametric analysis in relation to turbulent speed correlations and turbulence models and interpret the k-ω SST model blending function F1 behavior during the combustion process. The obtained results show that in the simulated case all three turbulent speed correlations behave similarly and can be used to reproduce observable flame speed; also, the k-ε model provides more accurate results than the k-ω SST turbulence model. It is shown in the paper that the k-ω SST model misinterprets the sudden parameter gradients resulting from turbulent combustion.
Surplus and capital profitability in the Spanish economy, and comparison with the Euro area. A political economy approach

ABSTRACT The article studies the evolution of both surplus and profit rates in the Spanish economy during the phase of the housing bubble, the subsequent crisis and the recent economic recovery (1995─2017), comparing as well core and peripheral economies of the Eurozone. From various methodological approaches and showing several indicators, this paper finds an underlying deep profitability crisis and an alarming drop in what we call the productivity of surplus, without reaching previous levels of profitability at the end of the period. This path has been offset by a reduction in interest rates, which promoted corporate indebtedness. The huge decrease of profitability in Spain is however consistent with its peripheral insertion into the Euro area. In opposition, the more advanced economies of the region were able to keep the level of capital profitability and even increasing the volume of surplus.
Epidemiology of congenital abnormalities in Bahrain

This study was carried out in order to find out the incidence of congenital anomalies in Bahrain. Statistics of the Bahraini Ministry of Health for 11 years from 1980 to 1990 were studied. The overall incidence rate of congenital anomalies in Bahrain was found to be 2. 7% of live births. Each anomaly was studied separately and compared with the incidence in other countries, whenever possible. It was found that anomalies of the musculoskeletal system have the highest incidence [2. 28 per 1000] , followed by the genitourinary system [2. 13 per 1000] , while the incidence of chromosomal disorders was 0. 9 per 1000
Treatment and Selection Effects of Formal Workplace Mentorship Programs

While formal mentorship programs are ubiquitous, less is known about who gains from receiving mentorship. In this paper, we report the outcome of a Randomized Controlled Trial (RCT) carried out in a US-based inbound sales call center where one branch of the experiment assigned a random subset of new hires to mentors (Broad-Mentoring), whereas a second branch (Selective-Mentoring) gave new hires the opportunity to opt into a mentoring relationship before assigning a random subset to mentors. In the Broad-Mentoring branch, mentored sales agents outperformed non-mentored agents by over 18% in the first six months on the job. Among agents who opt into the program in the Selective-Mentoring branch, those who received mentorship had negligible performance gains. The differences between the two branches indicates that formal mentorship program treatment effects are largest for workers who would otherwise opt out of these programs. Demographic and personality characteristics are relatively weak predictors of selection into the program, suggesting broad-based programs are likely more effective than alternative targeting rules.