Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of Metabolites in the Cerebellum of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Exposed Mice by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin elicits many harmful effects in tissues. Metabolomic changes and the associated pathway alterations caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the cerebellum, an area thought to be less affected by environmental alterations, remain unknown. Here, metabolomics was performed to identify endogenous metabolites that were associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin in the cerebellum of 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated mice using Fourier transform ion cyclotron resonance mass spectrometry. Distinct peaks were located in two mass ranges, 210 m/z–420 m/z and 450 m/z–570 m/z. In principal component space, the high-dose group was clearly separated from the control group. Six metabolites associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin dose were identified. The metabolite 1-palmitoyl lysophosphatidic acid increased with increasing doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin, indicating activation of the rat sarcoma pathway. Biosynthesis of the unsaturated fatty acid 18-hydroxyoleate was inhibited upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. The decrease in N-arachidonoyl taurine, implies that taurine increased, suggesting inhibition of neuronal signal transmission. A decrease in N-acetyl-aspartyl-glutamate has been associated with injury of the cerebellum through activation of N-methyl-D-aspartic acid receptors. An increase in glycerophosphoinositol suggests damage to blood–brain barrier function, and changes in purine metabolism were observed because inosine increased following 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. These results suggest that 2,3,7,8-tetrachlorodibenzo-p-dioxin activates the rat sarcoma pathway, alters fatty acid biosynthesis and purine metabolism, inhibits neurotransmitter systems, and is harmful to blood–brain barrier function in the cerebellum.
SURFACE PLASMON RESONANCE AND QUARTZ CRYSTAL MICROBALANCE IMMUNOSENSORS FOR DETECTION OF ESCHERICHIA COLI O157:H7

Surface plasmon resonance (SPR) and quartz crystal microbalance (QCM) techniques have been studied in label- free immunosensors for direct detection of bacteria. However, there is a lack of comparative investigations on SPR and QCM immunosensors. In this study, SPR and QCM immunosensors were compared for their applications in bacterial detection using Escherichia coli O157:H7 as a model pathogen. In both immunosensors, affinity-purified polyclonal antibodies were used as capture antibodies and Protein A method was used for antibody immobilization. The stepwise assembly of the immunosensors was characterized by SPR, QCM, and cyclic voltammetry. Both SPR and QCM could detect E. coli O157:H7 in 1 h with detection ranges of 105 to 108 and 106 to 108 CFU/mL, respectively. QCM was more sensitive than SPR in terms of both detection limit and signal-to-noise ratio. For both immunosensors, no significant interference was found from brain heart infusion (BHI) broth or Salmonella Typhimurium. The binding efficiency of the QCM immunosensor at 105 to 108 CFU/mL was found to be 95.9% to 2.9%, decreasing with increasing cell concentration.
Understanding Intermodel Variability in Future Projections of a Sahelian Storm Proxy and Southern Saharan Warming

Projected changes in the intensity of severe rain events over the North African Sahel—falling from large mesoscale convective systems—cannot be directly assessed from global climate models due to their inadequate resolution and parameterization of convection. Instead, the large-scale atmospheric drivers of these storms must be analyzed. Here we study changes in meridional lower-tropospheric temperature gradient across the Sahel (ΔTGrad), which affect storm development via zonal vertical wind shear and Saharan air layer characteristics. Projected changes in ΔTGrad vary substantially among models, adversely affecting planning decisions that need to be resilient to adverse risks, such as increased flooding. This study seeks to understand the causes of these projection uncertainties and finds three key drivers. The first is intermodel variability in remote warming, which has strongest impact on the eastern Sahel, decaying toward the west. Second, and most important, a warming–advection–circulation feedback in a narrow band along the southern Sahara varies in strength between models. Third, variations in southern Saharan evaporative anomalies weakly affect ΔTGrad, although for an outlier model these are sufficiently substantive to reduce warming here to below that of the global mean. Together these uncertain mechanisms lead to uncertain southern Saharan/northern Sahelian warming, causing the bulk of large intermodel variations in ΔTGrad. In the southern Sahel, a local negative feedback limits the contribution to uncertainties in ΔTGrad. This new knowledge of ΔTGrad projection uncertainties provides understanding that can be used, in combination with further research, to constrain projections of severe Sahelian storm activity.
Genotypic Characterization of Rhizopus species from Tempeh and Usar: Traditional Inoculum of Tempeh in Indonesia

Soybeans tempeh (tempeh) is processed by fermentation using Rhizopus spp. Tempeh is an important source of protein in Indonesia. The traditional inoculum in tempeh fermentation locally is known as Usar, which is made from the leaves of Hibiscus tiliaceus . However, Rhizopus information from Usar is still limited. Therefore, this study aims to identify and investigate the genetic diversity of Rhizopus species from Usar and tempeh based on the Internal Transcribed Spacer (ITS) sequences and the Random Amplified Polymorphic DNA (RAPD) markers. Twenty-three Rhizopus strains were isolated from Usar and ten Rhizopus strains were isolated from tempeh. Based on ITS sequences, the isolates were similar to Rhizopus microsporus (30 isolates) and Rhizopus delemar (3 isolates) with 98-99% similarity. The genetics of R. microsporus and R. delemar are varied and different from the genetics of R. microsporus from tempeh. The growth temperature of R. microsporus varies from 33°C to 48°C and R. delemar can grow to a maximum at 33°C. This research needs to be continued to obtain information about the role of Rhizopus from this study in determining the quality of tempeh.
Controllable synthesis of spinel nano-ZnMn2O4via a single source precursor route and its high capacity retention as anode material for lithium ion batteries

Agglomerated pure spinel ZnMn2O4 nanoparticles with flake-shaped structure have been synthesized viacalcination of an agglomerated Zn–Mn citrate complex precursor, which was prepared with high yield by a convenient, environmentally benign and low temperature route. The composition, morphology and thermal decomposition of the Zn–Mn citrate complex were studied by C&H elemental analysis (EA), Fourier transform infrared spectroscopy (FTIR), energy-dispersive spectroscopy (EDS), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The resulting ZnMn2O4 nanoparticles obtained from the precursor calcination at 700 °C were systematically characterized by XRD, FTIR, N2Adsorption/Desorption, SEM, TEM, HRTEM and selected area electron diffraction (SAED). The results show that the ZnMn2O4 material was agglomerated to form a porous texture in pure phase. The electrochemical properties of the agglomerated ZnMn2O4 material were investigated to determine its reversible capacity, rate and cycling performance as the anode material for lithium ion batteries (LIBs). This ZnMn2O4 material exhibited promising capacity retention of over 200 cycles at varying discharge rates. The electrode also exhibited attractive rate capabilities yielding capacity of 330 mAh g−1 after more than 35 cycles at 600 mA g−1.The ameliorated electrochemical performance can be ascribed to the high crystallinity and porous texture of the ZnMn2O4 material which provided short diffusion paths for lithium ions. Ex situXRD analysis of the electrodes after discharging and charging to the selected voltage was conducted and the possible lithium insertion mechanisms are discussed. This study suggests that the ZnMn2O4 material synthesized via the single source precursor route is a promising anode material for LIBs.
Comparison of Liver Function Tests in Normal Pregnancy with Non-pregnant Matched Controls

Background: Change of liver biochemical profiles is normal during pregnancy. It is almost impossible to understand disease processes that can threaten women during pregnancy without understanding normal physiological change. Aim of this study is to evaluate changes in serum liver function tests in normal pregnant women in first, second and third trimester. Material and Methods: The cross-sectional comparative study was carried out in the Department of Obstetrics & Gynaecology of Rajshahi Medical College Hospital, Bangladesh in 2019. This study consists of 90 pregnant women and 90 matched control. Among the 90 pregnant women, 30 were in first trimester, 30 were in second trimester and 30 were in third trimester. Blood samples were taken for routine liver function and protein profiles Results: Serum total and direct bilirubin concentrations were significantly lower in second and third trimester. The mean ALP level was slightly increased in 2nd trimester and drastically increased in 3rd trimesters during pregnancy. Serum ALT and AST activity was significantly increased in third trimester. No significant change in serum total proteins concentration, but serum albumin concentration was significantly lower and serum globulin concentration was significantly higher in all three trimester. Serum albumin/globulin ratio was significantly reduced in second and third trimester. Conclusion: Relative values of various liver function tests during gestational trimesters appear to be the best guide to confirm the diagnosis and treatment strategies. Thus, gynecologists should routinely monitor liver function tests in all gestational trimesters to avoid the future complications to mother and offspring. TAJ 2020; 33(1): 17-24
Some Anomalies in the Self-Diffusion of Water in Disordered Carbons

The unusual dynamics of water under confinement is important to a number of conventional and emerging industrial processes and to life in general; nevertheless, our understanding of this critical area is still in an early stage. Nanoporous carbons have provided a key material through which to investigate this dynamics; however, existing simulations have been based on the use of idealized slit pore carbons or carbon nanotubes with smooth energy landscapes and fail to capture the influence of structural disorder inherent to real carbons. We show here that the irregular structure of such carbons critically influences the dynamics and the mode of diffusion (single file, subdiffusion or Fickian). Our molecular dynamics simulations, using a realistic hydrophobic carbon model based on hybrid reverse Monte Carlo simulation of the structure of an activated carbon fiber, show the existence of a single-file diffusion mode between the ballistic and Fickian modes in the narrowest pore regions of this material, not see.
A fatal case of post endobronchial ultrasound transbronchial needle aspiration endobronchial haemorrhage: a case report and review of the literature

Notwithstanding life-threatening haemorrhagic complications, endobronchial ultrasound-guided transbronchial needle aspiration represents a cornerstone in the evaluation of NSCLC patients. Due to its low invasiveness and satisfactory tolerability even in high-risk patients, it is usually scheduled in one-day surgery hospital stay. Moreover, EBUS-TBNA offers a viable alternative to other conventional endoscopic procedures such as mediastinoscopy with the addiction to gain access also to hilar nodes. We report an unexpected and rare event of post-bronchoscopy fatal endobronchial haemorrhage in a 67-year-old female patient with a right S1 solitary pulmonary nodule and concomitant multiple bilateral lymphadenopaties. According to clinical staging the patient was unfit for upfront surgery and endoscopic procedure for tissue diagnosis was scheduled. The immediate postoperative period was uneventful as no intraoperative injuries were reported. Twenty-four hours later, the patient claimed respiratory distress and, after admission to the Emergency Department, a massive and uncontrolled bleeding coming from the lower respiratory tract was diagnosed leading to a death. Although one-day surgery EBUS-TBNA is the standard of care in patients undergoing endoscopic exploration, current guidelines seem to be murky about proper case stratification in order to plan an exhaustive observation time especially in high-risk patients.
Distribution of heavy metals in the surficial sediments of Izmir Bay (Turkey)

The distribution of heavy metals (Hg, Cd, Pb, Cr, Zn, Cu, Ni, Mn) were investigated in surficial sediments of Izmir Bay. The data were collected during cruises in July 1997 and January 1998, in the framework of a Izmir Bay Marine Research Project supported by Izmir Metropolitan Municipality. Heavy metal concentrations in the sediment samples showed significant enrichments during sampling periods from Inner Bay. Outer and Middle Bays show low levels of heavy metal enrichments except mouth of Gediz River. Gediz is the major source of anthropogenic input into the Outer Bay.
Influence of Patient Experience and Hospital Image on Patient Loyalty in Meloy Public Hospital of Sangatta, East Kutai Regency

BACKGROUND: Patient experience is an indicator in measuring the quality of service by placing patients as the center of service in the hospital. AIM: This study aimed to analyze the effect of patient experience and hospital image on patient loyalty, as well as the influence of patient experience and hospital image on patient loyalty through patient satisfaction variables in Meloy Public Hospital of Sangatta. METHODS: The design of this study was analytic observational design with cross-sectional study approach. This research was conducted at Meloy Public Hospital of Sangatta, East Kutai Regency since May to July 2019. The sample of this study was 110 respondents. The samples were taken in each treatment class at hospital by proportional stratified random sampling. In this study we used a questionnaire and univariate, bivariate, and multivariate analysis using path analysis. RESULTS: Patient experience affected patient satisfaction, hospital image affected patient satisfaction, patient experience did not directly influence patient loyalty, hospital image directly affected patient loyalty, and patient experience and hospital image indirectly affected loyalty patient through patient satisfaction. To the Meloy Public Hospital of Sangatta to maintain the good image of the hospital in providing services to the patient experience is memorable so that the desire arises to reuse hospital services in the future. CONCLUSION: Based on research on the Influence of Patient Experience and Hospital Image on Patient Loyalty in Meloy Public Hospital of Sangatta, East Kutai Regency, researchers formulated the following conclusions: Patient experience influences patient satisfaction at the hospital. The image of the hospital has an effect on patient satisfaction at the hospital. Patient experience does not directly affect patient loyalty in the hospital. The image of the hospital has a direct effect on patient loyalty at the hospital. Patient experience and hospital image have an indirect effect on patient loyalty through patient satisfaction at the hospital.
An Experimental Test of Some Economic Theories of Optimism

Economic theories of optimism provide different rationales for the phenomenon of motivated reasoning, and a recent empirical literature has tested some of them, with mixed results. We contribute to this literature with a novel experimental test of two mechanisms, according to which optimism is respectively predicted when (1) the potential material losses due to the bias are relatively small or (2) the cognitive costs of the bias are small enough. In our design, these two accounts predict inflated expectations regarding some future payoff. Contrary to that, the average subject tends to (slightly) underestimate that financial prospect. Although a minority of the subjects overestimate systematically, the size of their errors is rather reduced, and they hardly differ in their personal characteristics from the rest of the subjects. In fact, optimism in our experiment is correlated with the sample observed, in that it is more likely when a subject observes relatively few good signals. This is again at odds with (1) and (2). These mechanisms, we conclude, do not appear to fully capture under which circumstances people fail into a positivity bias. Yet (1) seems to be empirically less relevant, in that we observe a similarly limited level of bias irrespectively of its monetary cost.
ANALISIS PERILAKU IBU TENTANG CUCI TANGAN DENGAN KEJADIAN DIARE PADA BALITA DI RUMAH SAKIT MARDI RAHAYU KUDUS

ABSTRAK Diare merupakan salah satu masalah kesehatan di Indonesia.Diare merupakan penyebab kematian nomor dua pada balita, nomor tiga pada bayi dan nomor lima bagi sejumlah umur. Berdasarkan kelompok umur, penderita diare terbanyak pada kelompok umur 1-5 tahun. Banyak faktor yang menyebabkan diare pada balita salah satunya adalah perilaku ibu. Tercatat ada 461 balita yang terkena diare pada tahun 2018 dan setiap tahunnya mengalami peningkatan.Tujuan dalam penelitian ini untuk mengetahui adakah hubungan perilaku ibu tentang cuci tangan dengan kejadian diare pada balita Metode: Jenis penelitian ini adalah desfriptif corelatif dengan rancangan cross sectional. Populasi yang di pergunakan berjumlah 82 dengan menggunakan teknik accidental sampling. Penggumpulan data menggunakan alat ukur kuesioner.Metode analisa data menggunakan uji chi-quare. PenelitiAan dilakukan di Ruang Anak Rumah Sakit Mardi Rahayu Kudus dari akhir Maret sampai dengan akhir April 2019. Hasil menunjukkan bahwa terdapat hubungan antara perilaku ibu tentang cuci tangan dan kejadian diare pada balita (p = 0,000 < 0,05). Simpulan: Dengan mengunakan analisa chi square diperoleh hasil bahwa nilai P value nya 0,000. Jadi menurut standar dalam analisa kesehatan jika nilai P value < 0,05 berarti memiliki hubungan. Kata Kunci : Perilaku ibu, balita, kejadian diare
Mathematical Modeling of Thin Layer Drying Kinetics of Apple in Tunnel Dryer

In this study, the drying kinetics of apple (control, blanching and blanching in 1% potassium meta bisulphate) in a tunnel dryer was studied at 50, 60, and 70°C air temperatures. The drying of apple slices occurred in a falling rate period. It was found that treated apple slices dried faster. Six thin layer-drying models were fitted to the experimental moisture ratio. Among the mathematical models evaluated, the logarithmic model satisfactorily described the drying behaviour of apple slices with high r2 values. The effective moisture diffusivity (Deff) of apple slices increased as the drying air temperature increased. The Deff values were higher for the treated samples than for the control.
Biosolids Effect on Phosphorus, Copper, Zinc, Nickel, and Molybdenum Concentrations in Dryland Wheat

When biosolids that are low in trace elements are applied on cropland, the tissue concentrations of trace elements may approach a concentration plateau as cumulative quantity of the element added increases. If the plateau concentration is less than that of safe threshold, the application may continue indefinitely. We found that wheat (Triticum aestivum L. 'Vona' or 'TAM107') grain concentrations of P, Cu, Zn, and Ni from an 11-yr field study of biosolids land application follow a plateau model. The grain concentrations of P, Cu, and Zn approach the calculated plateau maximum after 11 applications (in fallow rotation, we completed six applications to one set of plots plus five applications to a second set). Grain Ni levels show a linear response to cumulative inputs of biosolids Ni. Possibly, the biosolids are providing a labile source of Ni. The Mo concentrations did not change significantly as cumulative inputs of biosolids Mo increased. Our results indicate that plateau modeling can describe the changes in wheat grain concentrations associated with biosolids application.
Secondary metabolites produced by endophytic bacteria against the Root-Knot Nematode (Meloidogyne sp.)

Maulidia V, Soesanto L, Syamsuddin, Khairan K, Hamaguchi T, Hasegawa K, Sriwati R. 2020. Secondary metabolites produced by endophytic bacteria against the Root-Knot Nematode (Meloidogyne sp.). Biodiversitas 21: 5270-5275. Endophytic bacteria live and colonize in plant tissues without causing disease to their plant host. Among several processes, these bacteria can produce secondary metabolites that can help in the defense of plant host against pathogens. This study aimed to identify endophytic bacteria as biocontrol agents against Meloidogyne sp. in tomato plants. Six endophytic bacteria candidates from the genus Pseudomonas, Arthrobacter, Bacillus, and Serratia were isolated from Solanum Lycopersicum, Psidium guajava, Pinus merkusii, Dendrocalamus asper, Albizia chinensis, and Theobroma cacao L, respectively. The average mortality of Meloidogyne sp. by endophytic bacteria was 70,27% to 95,46%. From these, Bacillus thuringiensis AK08 produced compounds of the secondary metabolites such as flavonoid, phenol, tannins, terpenoids, steroids, saponins, and alkaloids. The best result of the average incubation period, number of galls in the root, number of nematodes at the root, and the number of nematodes in the soil on tomato plant were shown by B. thuringiensis. The major compounds in GC-MS analysis of B. thuringiensis were cholest-5-en-3-ol (3.beta.)-carbonochloridate (25.35%). Bacillus thuringiensis not only has rules as bio-insecticide but also has nematicidal effect.
PENGARUH PRODUK, DISTRIBUSI DAN DIGITAL MARKETING TERHADAP MINAT BELI PRODUK UMKM BINAAN KADIN JABAR PADA SITUASI COVID-19

ABSTRAK Maksud dilakukannya penelitian ini adalah untuk mengetahui sampai sejauh mana produk,distribusi, digital marketing berpengaruh terhadap minat beli produk UMKM binaan Kadin Jabar dalam situasi covid-19. Metode penelitaan yang digunakan adalah deskriptif dan verifikatif. Berdasarkan hasil analisis regresi diperoleh koefisien regresi berganda baik secara simultan dan partial variable X memberikan pengaruh terhadap variabel Y sebesar 39,2%, sedangkan sisanya sebesar 60,8% lainnya merupakan kontribusi dari variabel lain yang tidak diteliti. Hasil penelitian membuktikan bahwa Produk dapat dikatakan cukup baik, berpengaruh terhadap minat beli Produk UMKM binaan Kadin Jabar sebesar 10,9%, Distribusi dapat dikatakan cukup baik, berpengaruh terhadap minat beli Produk UMKM binaan Kadin Jabar sebesar 13,2% dan Digital Marketing dapat dikatakan cukup baik, berpengaruh terhadap minat beli ulang sebesar 15.1%. Kata kunci : Produk, Distribusi, Digital Marketing, Minat Beli
Processing dependent thermal conductivity of nanoporous silica xerogel films

Sintered xerogel films (porous SiO2) show a much higher thermal conductivity than other low dielectric constant (low-K) materials available for the same value of K. The thermal conductivity of xerogels which we have processed using different methods is compared with that of other low-K materials such as silica hybrid (silsesquioxanes) and polymeric low-K materials. The methods used were: (1) single solvent (ethanol) method, (2) binary solvent (mixture of ethanol and ethylene glycol) method, (3) sintering. For the xerogel films, we show that process history is as important as the chemistry of the solid matrix or the porosity in determining the thermal conductivity. The thermal conductivity, measured by the 3-ω method or the photothermal deflection method, is affected by phonon scattering, which in turn is effected by the size and distribution of pores and particles and the presence of imperfections such as interfaces, substituted chemical species, impurities, microcracks, and microporosity. The thermal con.