Miracle-dz/UniFAR-FTUs huggingface dataset:
CD22 Expression in B-Cell Acute Lymphoblastic Leukemia: Biological Significance and Implications for Inotuzumab Therapy in Adults

CD22 is a surface molecule expressed early during the ontogeny of B cells in the bone marrow and spleen, and can be found on B cells isolated from the different lymphoid compartments in humans. CD22 is expressed by most blasts from the majority (60–90%) of B-cell acute lymphoblastic leukemia (B-ALL). Current therapies in adults with newly diagnosed B-ALL are associated with complete remission (CR) rates of 50–90%. However, 30–60% of these patients relapse, and only 25–40% achieve disease-free survival of three years or more. Chemotherapy regimens for patients with refractory/relapsed B-ALL are associated with CR rates ranging from 31% to 44%. Novel immune-targeted therapies, such as blinatumomab and inotuzumab (a humanized anti-CD22 monoclonal antibody conjugated to the cytotoxic antibiotic agent calicheamicin), provide potential means of circumventing chemo-refractory B-ALL cells through novel mechanisms of action. Eighty percent of inotuzumab-treated B-ALL patients may achieve a CR state. This review is focused on the biological and clinical activities of CD22 antibodies in B-ALL, and provides evidence about the potential role played by qualitative and quantitative analysis of the CD22 molecule on individual B-ALL blasts in predicting the depletion of leukemic cells, and, ultimately, leading to better clinical response rates.
Educational Program About Reproductive Health for Blind and Deaf Adolescent Girls in Assiut Governorate

Background: Persons with disabilities represent a significant portion of the world’s population and they are part of every community. They find that information on reproductive health (RH) is often inaccessible to them.Aim: evaluate the impact of an educational program about RH for blind and deaf adolescent girls. Methods: it was Quasi-experimental research design which conducted in Al Noor and Al Amal Schools in Assiut Governorate. The total sample was 80 girls. Tools: it included three tools: - a structured interview sheet, to assess disabled girls’ knowledge and attitudes towards RH and an observational checklist (using doll) to assess practice related perineal care. Results: All the studied sample (100%) has poor knowledge regarding to RH in pre test while their knowledge improved in post test to 58.8%. Regarding to perineal care, all of the studied sample (100%) carried out all steps of perineal care except three steps which include the correct direction for cleaning the perineum, while their practice improved in post and follow up test. Conclusion: All the studied girls have poor knowledge in pre test while after implementation the education programe their knowledge were improved (P= ≤ 0.001). Recommendation: Continues health education programs should be implemented for increasing awareness of them about reproductive health.
The biocultural evolution of inflammatory bowel diseases

Inflammatory bowel diseases (IBO}, such as Crohn's disease and ulcerative colitis, are described as abnonnal immune responses to the gastrointestinal microbiota. The etiology of IBO is unknown; however, it is associated with Western, industrialized societies. A better understanding of the origins and treatments of IBO can lead to improved health outcomes. This paper seeks to examine IBD from a cultural, environmental, and evolutionary perspective. The effects of cultural and environmental factors, such as diagnostic practices, diet, breastfeeding practices, antibiotic use, appendectomy, and environmental radiation exposure on the risk of developing IBO are discussed. The efficacy of various treatments for IBO will also be examined. This review suggests that IBO constitutes a maladaptive inflammatory response to microbial ecosystem changes in the gut brought about by a variety of external factors, including diet, breastfeeding, appendectomy, antibiotic usage, and environmental radiation exposure.
The vowel /u/ before deleted word-final /s/, /r/, and /θ/ in Eastern Andalusian Spanish

Eastern Andalusian Spanish deletes all coda consonants; yet, coda deletion analyses have focused on /-s/. The acoustic and statistical analyses of 317 tokens of /u/ in 24 Eastern Andalusian speakers confirm that the differences in quality between word-final /u/ and /u/ preceding deleted /-s/, /-r/, and /-θ/ are statistically significant. Furthermore, /-s/, /-r/, and /-θ/ deletion changes the quality of a preceding /u/ in different degrees but the difference of quality between these three realisations of /u/ is not statistically significant. Likewise, a perception experiment confirms that Eastern Andalusian speakers can identify whether or not /u/ is followed by an underlying /-s/, /-r/, or /-θ/; however, they cannot identify the deleted consonant.
Family Characteristics That Suffer Stunting in the Work Area of The District Health Center Langkat

Stunting is malnutrition a long time and have an adverse impact on health status, growth and development of children. Signs and symptoms of stunting is child's posture is short i.e. the height is not appropriate with age. Malnutrition in children is related to the characteristics of the family as a place of growing and the care of the child. This research is descriptive quantitative research with the aim to analyze the characteristics of families with children who suffer from stunting. The study population 136 as much as with the total sample of 30 mothers who have children and toddlers with simple random sampling. Data collection using a questionnaire, consisting of demographic data, the role of family function and health status associated with stunting. Data analysis univariate. The results of the research showed that the. The importance of assessing the characteristics of the family in the treatment in children and infants.
Do Emotions Expressed in the Social and News Media Impact on Investor Behaviour?

The study examines the relationship between emotions generated by the social and news media and the decision-making process of investors. The 11 different emotions that we evaluate are calculated on an on-going basis by applying advanced algorithms which scan the social and news media. We then align these emotions with corporate earnings announcements in order to gauge whether the investor response to the announcements is conditioned by the prevailing state of the emotions at the time of the earnings release. We find substantial evidence to suggest that the 11 different emotion indices have an impact on how investors respond to earnings announcements (of both good and bad news). Further we find it is the emotion emanating from the social media postings that have a larger impact on investor behaviour (and so markets) than those generated by scanning the news media. _____________________________________________________________________________ * School of Accounting Finance and Economics, Waikato Management School, University of Waikato ** Finance Discipline Group, University of Technology Sydney
Analysis of Consumers’ Preference for Local Rice among Households in Ekiti State, Nigeria

Consumers’ preference for local rice determines its demand. Therefore, the study was carried out to analyze consumers’ preference for local rice among households in Ekiti State. A multi-stage sampling procedure was used to select respondents for this study. A total of 240 women were randomly selected from three Local Government Areas (LGAs) in the State. Primary data were obtained with the use of a well-structured interview schedule. Data collected were analyzed using descriptive statistics as well as inferential statistic like logistic regression. The mean age of the respondents was 38 years and more than half (53.3%) of the respondents were females. Most (70.0%) of the respondents had a mean family size of 7 persons. Most (87.0%) preferred local rice and factors influencing consumers’ preference for local rice include good nutritional value, quality of rice and good taste. Local rice was very much preferred by the respondents. Logistic regression shows that significant influence exists between price, taste, availability of rice and presence of particles and preferred choice of rice. Therefore, efforts should be made by the government to formulate price control policy on local rice for its affordability by the consumers and there should be improvement on processing technology of local rice to eliminate presence of particles for improved quality and good taste to enhance the consumers’ preference for choice of rice. Also, the government should support farmers through provision of incentives and credit facilities so as to produce more local rice for its availability all year round. Review Article Ajayi and Ajiboye; ARJA, 12(1): 18-23, 2020; Article no.ARJA. 53388 19
Increasing Students’ Levels of Fluency by Reinforcing Sounds and Syllabic Recognition in their First Language of Spanish

This research studied the effects of an intervention, which the participants, received in their first language. It analyzed the effectiveness of having extensive knowledge of phonics in one’s first language in order to read fluently in one’s second language. It explored the student's ability to transfer their phonetic knowledge in their first language of Spanish when reading in English, their second language. The research examined the efficacy of didactic material in Spanish used during the research intervention. The goal of the intervention was to help English Language Learners transfer their phonetic knowledge from Spanish to English and as a result, improve their understanding of sounds in their second language to become fluent readers.
Effect of some light sources on broiler chickens performance under Assiut conditions, Egypt

This study aimed to compare the effect of three different light sources on the growth performance and carcass quality of broiler chickens. Birds were wing banded, individually weighed and randomly assigned to three experimental groups, each including three equal replicates each of 15 chicks. Birds in groups 1, 2 and 3 were exposed to light emitted from incandescent (INC), saving (SAV) and Light Emitting Diodes (LED) lamps, respectively. The studied traits included (BW), (BWG), mortality rate, (FC), (FCR), carcass traits and the economic efficiency. The average BW of broilers in (T2) was significantly higher (P≤0.05) at 2, 4, 5 and 6 weeks than those of birds in (T1) and the (control). The best average of the all experimental period FCR7 g (1.71) was recorded in T2 improving significantly (P≤0.05) than those 1.78 and 1.83 g of (T1) and the (control), respectively. In the same group, (T2) significantly (P≤0.05) increased the percentages of Carcass, Gizzard, Liver, Heart, Spleen, Giblets and dressing than those of the birds in (T1) and the control. Economically, the use of (LED) as lighting source decreased the costs of the lighting program by about 82.87% compared with the (INC) control. The results of this study indicated that the using of (LED) is highly recommended in the broiler production to achieve the best possible profit, especially with the progressive increase in the prices of feed ingredients and power cost.
A Better Specified Asset Pricing Model to Explain the Cross-section and Time-Series of Commodity Returns∗

We show that a model featuring an average commodity factor, a commodity carry factor, and a commodity momentum factor is capable of describing both the cross-sectional and time-series variation of commodity returns. Going beyond extant studies, our empirical results indicate that more parsimonious oneand twofactor models that feature the average and/or carry factors are rejected and the momentum factor contains additional information beyond that conveyed by the carry factor. Furthermore, we find that additional factors (e.g., value or volatility) are statistically and economically insignificant. Together, the three factors appear to forecast real economic activity, returns of bonds, equities, and commodity currencies, and they correlate with economic fundamentals. We explore economic interpretations of our findings and the sources of model performance.
Effect of Family History on Clinical and Pathological Characteristics of Breast Cancer: a Hospital-Based Study in Egypt

Abstract: Background: Breast cancer is the most common female malignancy. The family history of breast cancer increases the risk of the disease. Objectives: To assess the frequency of familial breast cancer among breast cancer patients attending oncology outpatient clinics in Menoufia University Hospital and to compare the clinical and pathological characteristics of familial and sporadic breast cancer. Methods: The study was conducted on 150 women with familial or sporadic breast cancer who were attending oncology outpatient clinics, Menoufia University Hospital for follow up or receiving treatment. The participants were interviewed by predesigned questionnaire to assess risk factors for breast cancer. Data on different characteristics of the tumors were gathered from patients’ medical records. Results: Familial cases represented 18.7% of studied breast cancer patients. The age of onset seems to be younger in familial breast cancers (P=0.008). Percentage of familial breast cancer cases was significantly more prevalent among premenopausal females (P=0.007). Percentage of studied cases who breastfed their babies, had bilateral breast cancer, had triple negative breast cancer and with larger tumor size (T4) was significantly more prevalent among familial than sporadic breast cancer cases (P=0.023, 0.006, 0.000, 0.000 respectively). About 63% of sporadic cases were among hormonal contraceptive users versus 43% in familial group (P=0.040). There was no significant difference between familial and sporadic groups regarding histological type was observed. Conclusion: Familial cases represented 18.7% of studied breast cancer patients. Familial breast cancer seems to affect premenopausal young women and tends to present at the larger size, bilateral and triple negative tumors.
2008,Gynecol Endo, PCOS & VPA women

Valproate (VPA) is a highly effective drug successfully employed in several neuropsychiatric diseases. In the last 15 years, an increased prevalence of polycystic ovary syndrome (PCOS) associated with VPA use has been reported in both women with epilepsy and women with bipolar disorders. However, data on this subject are contrasting and it is possible that different factors might play a role in the development of PCOS in these patients. The risk of developing PCOS during VPA treatment seems to be higher in women with epilepsy than in women with bipolar disorders, and this might be due to an underlying neuroendocrine dysfunction related to the seizure disorder. Gynecologists must be aware of the possibility that PCOS in these populations of patients might be related to VPA use, and a careful multi-specialist approach is required for evaluating the risks and benefits of this treatment in the presence of features of PCOS.
Publicly Provided Preschool and Maternal Labor Supply: Evidence from Three Head Start Natural Experiments

A considerable literature has tried to understand how the low-income preschool program Head Start affects participating children, but this program is likely to influence the decisions of other family members as well. For a low-income mother, access to Head Start likely provides a massive childcare cost subsidy, which might influence her labor supply decisions. To identify the impact of Head Start on the work decisions of single mothers, we will exploit variation from three evaluations. First, we exploit the substantial funding and enrollment expansion to Head Start in the 1990s that varied over time and across metropolitan areas to measure labor supply responses. We use the Current Population Survey to compare mothers with age-eligible children to mothers with children below the age threshold. We find that on average, these Head Start expansions are associated with a 2 percentage point increase in the employment rate of single mothers, which would imply that about 50 percent of the mothers who gain access to the program enter employment. We corroborate this evidence with the initial, staggered roll-out of Head Start in the 1960s and the Head Start Impact Study randomized control trial in 2002. In both cases, we find that Head Start is associated with an increase in employment for some mothers. Evidence from the impact study suggest effects appear to be largest when a mother does not have younger children or when Head Start offers full day programing. This suggests that viewing publicly provided early childhood education programs like Head Start as a bundle of family-level treatments can perhaps shed new light on the short run impacts, mid run fade out, and long-run improvements associated with Head Start.
Metabolic responses to long-term food deprivation in subterranean and surface amphipods

A long-standing hypothesis in subterranean biology posits that organisms living in poor resource subsurface habitats can withstand long periods of bioenergetic shortages due to an innate reduced metabolic rate when compared to their epigean counterparts. However, previous studies have proposed that caves with ample energy resources may not evolve organisms with reduced metabolic rate. The equivocal nature of previous findings suggests that there is a need to compare food deprivation responses of subterranean and surface species in order to elucidate whether there are widespread adaptations to low energy systems in subterranean taxa. The purpose of the study was to examine patterns in basal metabolism and the effects of food deprivation in closely related subterraneanand epigeanamphipods, Stygobromus pecki and Synurella sp. from central and east Texas, USA, respectively. Basal metabolic rates (measured as O2 consumption) differed between species, with S. pecki having substantially lower rates than Synurella. Individuals of both species were food deprived for a pre-determined time interval and changes in total body protein, lipids, and carbohydrates were measured throughout food deprivation experiments. Stygobromus pecki had larger initial energy stores than Synurella and were more conservative in the use of energetic reserves over a prolonged period of food deprivation. Thus, it appears that although S. pecki are currently found in shallow phreatic and spring opening environments, they have maintained more efficient metabolic adaptations to deal with prolonged periods of food deprivation.
Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer

Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein that is highly expressed in several types of malignant tumor, including malignant pleural mesothelioma, ovarian cancer and pancreatic adenocarcinoma. Recently, a comprehensive immunohistochemical study using MN-1 monoclonal antibody identified a significant number of colorectal tumors in which MSLN was expressed. However, the clinicopathological profiles and survival of patients with MSLN-positive colorectal cancer have not been fully analyzed. In the current study, the expression of MSLN in 270 primary and 44 metastatic colorectal tumors was immunohistochemically analyzed to determine the clinical usefulness of MSLN immunohistochemistry and to identify potential candidates for future anti-MSLN therapy. In vitro experiments using colon cancer cell lines were performed to investigate the biological significance of MSLN expression in tumors. The results of univariate analyses identified a significant correlation between MSLN expression and females (P=0.0042). Furthermore, an inverse correlation between MSLN expression and solid/sheet-like proliferation (P=0.014) was also revealed. Additionally, overall survival was significantly shorter in patients with diffuse luminal/membranous expression of MSLN (P=0.018). Multivariable Cox hazards regression analysis revealed diffuse MSLN expression (hazard ratio, 2.26; 95% confidence interval, 1.04–4.91; P=0.039) as a potential risk factor. When comparing primary CRCs and the metastasis of each, a weakly positive correlation was identified for MSLN positivity (% positive cells; R=0.484; P<0.0001). The in vitro experiments revealed a positive role for MSLN in colon cancer cell proliferation. Thus, MSLN immunohistochemistry may be useful in the prognostication of patients with CRC. The results demonstrated that significant numbers of patients with MSLN-positive CRC exhibiting metastasis could be targeted by anti-MSLN therapies.
Scaling the response of circular plates subjected to large and close-range spherical explosions. Part II: Buried charges

This paper discusses scaling of the dynamic response of clamped circular plates subjected to close-range, large spherical blast loadings that are flush buried in dry sand. As a continuation of part I which dealt with air blasts, similarity is obtained by using replica scaling for all geometrical parameters, while the blast effect is scaled by using the Hopkinson scaling law. In the case of buried charges, both the depth of burial and nature of the soil have a significant effect on the energy which is directed towards the target by funneling and magnifying it upwards. This paper addresses the effect of flush burial on the target’s dynamic response compared to a target loaded by similar air-blast energy. We present numerical and experimental results from a series of controlled explosion experiments. The experimental and numerical results agree quite well, so that the main outcome of this study is that scaling can be successfully applied to assess the dynamic response of circular steel armor plates subjected to close-range, buried large spherical explosions. r 2006 Elsevier Ltd. All rights reserved.
Perception of population ageing and age discrimination across EU countries

Population ageing is the most dominant demographic challenge that the European Union is experiencing in the 21st century. This may create negative attitudes and lead to discrimination against persons of advanced age. Age-related stereotypes and prejudice can result in age discrimination, termed ageism. This research concerns the question of perceived ageism towards older people in 25 EU countries, surveyed in 2015 using the Special Eurobarometer 437. The analytical section includes descriptive findings and the results of three multi-level regression models addressing three domains (explained variables) of perceived ageism: 1) discrimination in general, 2) discrimination during economic crisis, and 3) discrimination when electing an older person as a high official. The two-level regression allowed simultaneous modelling of individual-level (gender, age, partnership status, social class, and life satisfaction) and of country-level (life expectancy at 55, perceived start of old age, and HDI) effects. The personal characteristics impacted much stronger perceived ageism than country contexts. Ageist perception in general has mostly been noted at pre-retirement age, but the age profile has not been the same across three regression models. The East-West gradient, frequently reported, is questioned because the geographical picture of perceived ageism is rather puzzling.