Miracle-dz/UniFAR-FTUs huggingface dataset:
Advancing a Contextualized, Community-Centric Understanding of Social Entrepreneurial Ecosystems

We investigate what distinguishes social entrepreneurial ecosystems (SEEs) from entrepreneurial ecosystems (EEs) through appreciation of the importance of context—the multiplex of intertwined social, spatial, temporal, historical, cultural, and political influences. Community is incorporated as a key variable and hitherto overlooked dimension of the structure and influence of SEEs. We draw on extant literature and examples of a variety of SEEs to support our propositions and demonstrate why considerations of both context and community are critical to advance understanding of SEEs. We contribute to the study of SEEs by presenting a new conceptual framework and theorizing SEE as an evolving composite of interdependent actors who interact and collaborate across multiple levels to collectively generate positive externalities and drive sustainable solutions to social problems.
Duguetia pycnastera Sandwith (Annonaceae) Leaf Essential Oil Inhibits HepG2 Cell Growth In Vitro and In Vivo

Duguetia pycnastera Sandwith (Annonaceae) is a tropical tree that can be found in the Guyanas, Bolivia, Venezuela, and Brazil. In Brazil, it is popularly known as “ata”, “envira”, “envira-preta”, and “envira-surucucu”. In the present work, we investigated the in vitro and in vivo HepG2 cell growth inhibition capacity of D. pycnastera leaf essential oil (EO). The chemical composition of the EO was determined by GC–MS and GC–FID analyses. The alamar blue assay was used to examine the in vitro cytotoxicity of EO in cancer cell lines and non-cancerous cells. In EO-treated HepG2 cells, DNA fragmentation was measured by flow cytometry. The in vivo antitumor activity of the EO was assessed in C.B-17 SCID mice xenografted with HepG2 cells treated with the EO at a dosage of 40 mg/kg. Chemical composition analysis displayed the sesquiterpenes α-gurjunene (26.83%), bicyclogermacrene (24.90%), germacrene D (15.35%), and spathulenol (12.97%) as the main EO constituents. The EO exhibited cytotoxicity, with IC50 values ranging from 3.28 to 39.39 μg/mL in the cancer cell lines SCC4 and CAL27, respectively. The cytotoxic activity of the EO in non-cancerous cells revealed IC50 values of 16.57, 21.28, and >50 μg/mL for MRC-5, PBMC, and BJ cells, respectively. An increase of the fragmented DNA content was observed in EO-treated HepG2 cells. In vivo, EO displayed tumor mass inhibition activity by 47.76%. These findings imply that D. pycnastera leaf EO may have anti-liver cancer properties.
Maternal High-Fat Diet Programs White and Brown Adipose Tissues In Vivo in Mice, with Different Metabolic and Microbiota Patterns in Obesity-Susceptible or Obesity-Resistant Offspring

Maternal obesity causes metabolic dysfunction in the offspring, including dysbiosis, overeating, obesity, and type 2 diabetes. Early-life phases are fundamental for developing subcutaneous (SAT) and brown adipose tissues (BAT), handling energy excesses. Imaging of 18F-fluorodeoxyglucose by positron emission tomography (PET) and radiodensity by computerized tomography (CT) allows assessing adipose tissue (AT) whitening and browning in vivo and the underlying metabolic efficiency. Our aim was to examine these in vivo traits in SAT and BAT concerning gut microbiota composition in 1- and 6-month-old mice born to normal (NDoff) and high-fat diet-fed dams (HFDoff), accounting for body weight responses. We found low radiodensity (high lipids) in HFDoff SAT at 1 month, relating to an increased abundance of Dorea genus in the caecum and activation of the fatty acid biosynthetic pathway. Instead, low BAT radiodensity and glucose uptake were seen in adult HFDoff. Glucose was shifted in favor of BAT at 1 month and SAT at 6 months. In adults, unclassified Enterococcaceae and Rikenellaceae, and Bacillus genera were negatively related to BAT, whereas unclassified Clostridiales genera were related to SAT metabolism. Stratification of HFDoff based on weight-response, namely maternal induced obesity (MIO-HFDoff) or obesity-resistant (MIOR-HFDoff), showed sex dimorphism. Both subgroups were hyperphagic, but only obese mice had hyper-leptinemia and hyper-resistinemia, together with BAT dysfunction, whereas non-obese HFDoff had hyperglycemia and SAT hypermetabolism. In the caecum, unclassified Rikenellaceae (10-fold enrichment in MIO-HFDoff) and Clostridiales genera (4-fold deficiency in MIOR-HFDoff) were important discriminators of these two phenotypes. In conclusion, SAT whitening is an early abnormality in the offspring of HFD dams. In adult life, maternal HFD and the induced excessive food intake translates into a dimorphic phenotype involving SAT, BAT, and microbiota distinctively, reflecting maternal diet*sex interaction. This helps explain inter-individual variability in fetal programming and the higher rates of type 2 diabetes observed in adult women born to obese mothers, supporting personalized risk assessment, prevention, and treatment.
Relationship between Self-Efficacy and Headache Impact, Anxiety, and Physical Activity Levels in Patients with Chronic Tension-Type Headache: An Observational Study

Background Chronic tension-type headache is the primary headache with the highest prevalence. The present study is aimed at analyzing the associations between patient self-efficacy and headache impact with pain characteristics, kinesiophobia, anxiety sensitivity, and physical activity levels in subjects with chronic tension-type headache. Materials and Methods An observational descriptive study was carried out. A total sample of 42 participants was recruited at university environment with diagnosis of tension-type headache. Headache characteristics (frequency, intensity, and duration), physical activity levels, pain related-self-efficacy, kinesiophobia, anxiety sensitivity, and headache impact were measured. Results The HIT-6 (61.05 ± 6.38) score showed significant moderate positive correlations with the ASI-3 score (17.64 ± 16.22; r = 0.47) and moderate negative correlations with the self-efficacy in the domains of pain management (31.9 ± 10.28; r = −0.43) and coping with symptoms (53.81 ± 14.19; r = −0.47). ASI-3 score had a negative large correlation with self-efficacy in the domains of pain management (r = −0.59), physical function (53.36 ± 7.99; r = −0.55), and coping with symptoms (r = −0.68). Physical activity levels showed positive moderate correlations with the self-efficacy in the domain of physical function (r = 0.41). Linear regression models determined that the self-efficacy and anxiety sensitivity with showed a significant relationship with the HIT-6 score (R2 = 0.262; p = 0.008) and with the ASI-3 score (R2 = 0.565; p < 0.001). In addition, no correlations were found between pain intensity, duration or frecuency with psychosocial factors, or headache impact. Conclusions The present study showed that patients with chronic tension-type headache had a great negative impact on daily tasks and physical activity levels, which were associated with higher anxiety levels and lower self-efficacy.
Topology, geometry and field theory

Moduli of anti-self-dual conformal structures, M. Itoh reducible connections on non-simply connected 4-manifolds, Y. -B. Ruan a formulation of symplectic floer homology for Heegard splitting, T. Yosida one approach for Witten's invariants in Chern-Simons gauge theory, T. Gocho quantum groups at roots of unity and 3-manifold invariants T. Takata problems on the structure of the mapping class group of surfaces and the topology of the moduli space of curves, S. Morita monodromy representations of conformal field theory and their applications, T. Kohno torus actions and the topology and symplectic geometry of flat connection on 2-manifolds, L. Jeffrey four manifold invariants of finitely presentable groups, D. Kotschick matrix integrals and integrable systems, M. Mulase. (Part contents)
On optimal stopping of risk processes with regime switching

Abstract In the paper we solve a problem of optimal stopping of a risk process in two alternative settings. We assume that the main characteristics of the risk process change according to unobservable random variable. In the first model we assume that the post-disorder distributions are not known a’priori and are randomly chosen from a finite set of admissible distributions. The second model concentrates on a situation when more than one disorder is possible. For both models optimal stopping rules with respect to given utility function are constructed using dynamic programming methodology.
Erratum: “The Spatial Clustering of Ultraluminous Infrared Galaxies over 1.5 < z < 3” (ApJ 641, L17 [2006])

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Consumers’ buying interest to purchase pixy beauty products in Ambon City: The influence of beauty vlogger endorse and brand personality

The development of the internet has given rise to various platforms in promoting products variety. One of the platforms that are currently being a reference for internet users is vlogs. The influence of a vlogger can be influentially positive for increasing sales of a product.This research examines and analyzes the influence of the beauty vlogger endorsements and brand personality variables on the buying interest of Pixy beauty products in Ambon city. It takes samples from women in Ambon city interested in buying Pixy beauty products since they are influenced by endorse reviews from beauty vloggers and are strengthened by the brand personality of Pixy products.This research uses a questionnaire method as a data collection tool for as many as 108 respondents with purposive sampling. The method used in this research is quantitative analysis with multiple linear regression using the SPSS (Statistical Package for Social Science) data analysis program version 25.The multiple regression analysis test results show that the beauty vlogger endorse variable has a positive and significant influence on buying interest with a regression result of 0.230. The brand personality variable has a positive and significant impact on purchase interest with a regression result of 0.486. It indicates that brand personality is more assertive in shaping consumer buying interest than beauty vloggers. Therefore, companies must keep trying to form and strengthen brand personality to create a positive impression in the minds of consumers.
Impact of Digital Literacy and Problematic Smartphone Use on Life Satisfaction: Comparing Pre- and Post-COVID-19 Pandemic

Although the impact of digital literacy (DL) and problematic smartphone use (PSU) on life satisfaction was verified in previous literature, little is known about how the impact of two given variables can be differentiated during the COVID-19 pandemic situation. Thus, the purpose of this study was to empirically analyze whether the influence of DL and PSU on life satisfaction has changed as a consequence of the COVID-19 pandemic. We applied a cross-sectional study design to analyze data obtained from a nationwide survey on smartphone overdependence conducted in 2019 and 2020 by the South Korean Ministry of Science and ICT and the National Information Society Agency. Large-scale data obtained from 41,883 individuals were analyzed using hierarchical regression analysis. The results show that the positive relationship between digital literacy and life satisfaction was further strengthened post-COVID-19 rather than pre-COVID-19. In addition, the results suggest that the negative relationship between PSU and life satisfaction is further strengthened during post-COVID-19 rather than pre-COVID-19. The findings indicate that the roles of digital literacy and PSU are more important after the COVID-19 pandemic.
Viability and Adhesion of Periodontal Ligament Fibroblasts on a Hydroxyapatite Scaffold Combined with Collagen, Polylactic Acid–Polyglycolic Acid Copolymer and Platelet-Rich Fibrin: A Preclinical Pilot Study

Background: Conventional periodontal therapy relies on bone regeneration strategies utilizing scaffolds made of diverse materials, among which collagen, to promote cell adhesion and growth. Objective: To evaluate periodontal ligament fibroblast (HPdLF) cell adhesion and viability for periodontal regeneration purposes on hydroxyapatite scaffolds containing collagen (HAp-egg shell) combined with polylactic acid–polyglycolic acid copolymer (PLGA) and Platelet-Rich Fibrin (PRF). Methods: Four variations of the HAp-egg shell were used to seed HPdLF for 24 h and evaluate cell viability through a live/dead assay: (1) (HAp-egg shell/PLGA), (2) (HAp-egg shell/PLGA + collagen), (3) (HAp-egg shell/PLGA + PRF) and (4) (HAp-egg shell/PLGA + PRF + collagen). Cell adhesion and viability were determined using confocal microscopy and quantified using central tendency and dispersion measurements; significant differences were determined using ANOVA (p < 0.05). Results: Group 1 presented low cell viability and adhesion (3.70–10.17%); groups 2 and 3 presented high cell viability and low cell adhesion (group 2, 59.2–11.1%, group 3, 58–4.6%); group 4 presented the highest cell viability (82.8%) and moderate cell adhesion (45%) (p = 0.474). Conclusions: The effect of collagen on the HAp-egg shell/PLGA scaffold combined with PRF favored HPdLF cell adhesion and viability and could clinically have a positive effect on bone defect resolution and the regeneration of periodontal ligament tissue.
The Impact of Performance of Non-Nursing Tasks on the Attitudes of Nursing Students toward Nursing Profession

Background: Performing non-nursing tasks (NNTs) by registered nurses is considered as one of the most challenging issues faced by nursing sector worldwide. The negative impacts of nurses’ engagement in NNTs were not limited to nurses or clients, but also nursing students who train in clinical areas. Performance of NNTs is found to aggravate nurses’ confusion about their professional roles and identity. However, the impact of performance of NNTs on nursing students has not been yet studied. Purpose: This study aimed to investigate the impact of witnessing performance of non-nursing tasks by registered nurses on nursing students’ attitudes toward the nursing profession.Methods: A descriptive comparative study was conducted from September 2021 to January 2022. A convenience sampling was used and 409 valid questionnaires were obtained from Jordanian nursing students who were at least in their second academic year and had completed at least one clinical training period in one of the clinical settings. Attitude Scale for Nursing Profession was used to explore the participants’ attitudes toward the nursing profession. Descriptive statistics and independent t-test test were used for data analysis.Results: The results revealed that approximately 48% of the participants witnessed performance of NNTs by registered nurses during their clinical training. Student participants who witnessed performance of NNTs (M=154.4, SD=17.5) showed significantly less positive attitude toward the nursing profession than those who did not witness (M=157.4, SD=12.2), t(407)=-2.03, p=0.007). Conclusion: Around half of student participants witnessed performance of NNTs by registered nurses during clinical training. Performance of NNTs had a significant effect on nursing students’ attitudes toward nursing profession. Appropriate measures should be prior to clinical training to enhance nurse students’ awareness about professional scope of nursing profession.
Unlacing the lace expansion: a survey to hypercube percolation

The purpose of this note is twofold. First, we survey the study of the percolation phase transition on the Hamming hypercube {0,1}^m obtained in the series of papers [9,10,11,24]. Secondly, we explain how this study can be performed without the use of the so-called "lace-expansion" technique. To that aim, we provide a novel simple proof that the triangle condition holds at the critical probability. We hope that some of these techniques will be useful to obtain non-perturbative proofs in the analogous, yet much more difficult study on high-dimensional tori.
Gender, School Background, Personality, and Performance of Gifted and Regular Students in Indonesian National Competitions

This study investigated the relationship between gender, school type, school location, personality, and winning a medal among participants of the two largest student competitions in Indonesia, the National Science Competition (KSN) and the Entrepreneur-based Student National Competition (FIKSI), sponsored by the Indonesian Ministry of Education and Culture. Survey data were collected from 684 participants in KSN and 169 participants in FIKSI. The chi-square test and the logistic regression were employed using Jeffey’s Amazing Statistics Program (JASP) ver. 13. The results revealed a substantial relationship between gender, school location, school type, and personality on winning a medal in KSN, but none in FIKSI. Results also revealed that male participants and participants from Java and private schools were more likely to win medals in KSN than female participants and participants from outside Java and public schools. This study also found that neuroticism has a statistically significant relationship toward receiving a medal in KSN.
Nutritional interventions and outcomes of children with short bowel syndrome in a tertiary hospital setting in South Africa

Objectives: To describe the impact of nutritional interventions on the outcomes of children with short bowel syndrome (SBS). Design: This was a retrospective descriptive observational review where data were obtained from the patient’s medical records. Subjects and setting: Children with SBS between the ages of 0 and 24 months who obtained this diagnosis between January 2005 and December 2015 at a tertiary paediatric hospital in Cape Town were investigated. Results: There were 46 patients (62% male, 38% female) included in the study. The median duration of parenteral nutrition (PN) support was one month (0.6, 2.2 months), after which 83% of patients were weaned from PN. Enteral nutrition was commenced in 96% of patients, with the majority (n = 36; 82%) starting on day six (±6; range 1–29 days) postoperatively and 80% of patients attaining full feeds at median 1.2 months (0.2, 36 months). Patients displayed a mean weight and length gain of 15 g/day (±4; range 19–92 g) and 2 cm/month (±1.4; range 0.25–4 cm) respectively. The main complications were PN-associated cholestasis (n = 17), fat malabsorption (n = 13) and vitamin D deficiency/insufficiency (n = 5). Conclusion: This study showed that early initiation of PN support was attained, and that most patients were able to achieve enteral autonomy.
Development of Liver-on-Chip Integrating a Hydroscaffold Mimicking the Liver’s Extracellular Matrix

The 3Rs guidelines recommend replacing animal testing with alternative models. One of the solutions proposed is organ-on-chip technology in which liver-on-chip is one of the most promising alternatives for drug screening and toxicological assays. The main challenge is to achieve the relevant in vivo-like functionalities of the liver tissue in an optimized cellular microenvironment. Here, we investigated the development of hepatic cells under dynamic conditions inside a 3D hydroscaffold embedded in a microfluidic device. The hydroscaffold is made of hyaluronic acid and composed of liver extracellular matrix components (galactosamine, collagen I/IV) with RGDS (Arg-Gly-Asp-Ser) sites for cell adhesion. The HepG2/C3A cell line was cultured under a flow rate of 10 µL/min for 21 days. After seeding, the cells formed aggregates and proliferated, forming 3D spheroids. The cell viability, functionality, and spheroid integrity were investigated and compared to static cultures. The results showed a 3D aggregate organization of the cells up to large spheroid formations, high viability and albumin production, and an enhancement of HepG2 cell functionalities. Overall, these results highlighted the role of the liver-on-chip model coupled with a hydroscaffold in the enhancement of cell functions and its potential for engineering a relevant liver model for drug screening and disease study.
Cannabidiol use among patients with substance use disorders

ABSTRACT Background Preclinical and clinical studies suggest a promising potential of cannabidiol (CBD) for the treatment of substance use disorders (SUD). We therefore aimed to assess the prevalence, patterns, and self-perceived benefits of non-prescription CBD use among SUD patients. Methods A sample of 469 SUD patients treated as inpatients was included to this study. Information on CBD use was assessed by a standardized questionnaire. The sociodemographic and clinical data were extracted from the electronic medical database. Results About one-third of the SUD patients reported that they had used CBD at least once, but only about 9% of them were using CBD on a regular basis for more than a year. More than 40% of those patients using CBD for more than a year reported that CBD helped them to relax and to sleep better, and more than 30% of them reported that it helped them to reduce pain and to feel less anxious. Conclusions Regular use of CBD does not seem to be a common phenomenon among SUD patients, presumably due to its lack of psychotropic effects. However, the results provide a weak indication of self-perceived beneficial effects of long-term CBD use regarding agitation, sleep disorders, anxiety, and pain.
Gastrointestinal Tract Polyp Anomaly Segmentation on Colonoscopy Images Using Graft-U-Net

Computer-aided polyp segmentation is a crucial task that supports gastroenterologists in examining and resecting anomalous tissue in the gastrointestinal tract. The disease polyps grow mainly in the colorectal area of the gastrointestinal tract and in the mucous membrane, which has protrusions of micro-abnormal tissue that increase the risk of incurable diseases such as cancer. So, the early examination of polyps can decrease the chance of the polyps growing into cancer, such as adenomas, which can change into cancer. Deep learning-based diagnostic systems play a vital role in diagnosing diseases in the early stages. A deep learning method, Graft-U-Net, is proposed to segment polyps using colonoscopy frames. Graft-U-Net is a modified version of UNet, which comprises three stages, including the preprocessing, encoder, and decoder stages. The preprocessing technique is used to improve the contrast of the colonoscopy frames. Graft-U-Net comprises encoder and decoder blocks where the encoder analyzes features, while the decoder performs the features’ synthesizing processes. The Graft-U-Net model offers better segmentation results than existing deep learning models. The experiments were conducted using two open-access datasets, Kvasir-SEG and CVC-ClinicDB. The datasets were prepared from the large bowel of the gastrointestinal tract by performing a colonoscopy procedure. The anticipated model outperforms in terms of its mean Dice of 96.61% and mean Intersection over Union (mIoU) of 82.45% with the Kvasir-SEG dataset. Similarly, with the CVC-ClinicDB dataset, the method achieved a mean Dice of 89.95% and an mIoU of 81.38%.