Miracle-dz/UniFAR-FTUs huggingface dataset:
The physicochemical and microbiological quality of meat produced in a traditional slaughterhouse in Mansoura City, Egypt.

INTRODUCTION In several developing countries the slaughter of meat producing animals is still practiced in traditional slaughterhouses. In the Mansoura slaughterhouse, animals are subjected to various stressors and treated with cruelty, in addition to unhygienic treatment and handling of animal carcasses. Hence, this study was designed to investigate the meat quality from cattle, buffalo, and sheep carcasses processed in an old-fashioned slaughterhouse from Mansoura city, Egypt, in the context of pre-slaughter stress. METHODOLOGY The bleeding efficiency and the ultimate pH (pHu) of carcasses were tested, along with the effect of post-slaughter handling practice on the microbiological properties of meat. RESULTS From the 351 examined animals, the ultimate pH (pHu) was less than 5.8 in 81 cases (23.1%) and higher than 6.0 in 165 cases (47%). Furthermore, 45 (12.8%), 270 (76.9%), and 36 (10.3%) of the tested carcasses were well-, moderate- and imperfectly-bled, respectively. Cultivation using the wet-dry triple swab technique sampled from the outer surfaces of cattle, buffalo, and sheep carcasses revealed that about 47.9% of the tested carcasses were contaminated, with total viable count levels exceeding 7 log10 cfu/cm2, and 42.7% were contaminated with Enterobacteriaceae, with levels > 3 log10 cfu/cm2. The molds and yeasts from the tested carcasses had lower counts (< 2 log10 cfu/cm2). CONCLUSIONS Results indicated neglect in terms of sanitary measures during slaughtering and dressing of carcasses, with subsequent higher microbial contamination and impaired meat quality. Therefore, the traditional slaughtering facilities should be modernized to increase their meat producing efficiency, subsequently leading to exportation possibilities.
Implementation of a Personalized Digital App for Pediatric Preanesthesia Evaluation and Education: Ongoing Usability Analysis and Dynamic Improvement Scheme

Background Preanesthesia evaluation is a basic practice preceding any surgical procedure, aimed at tailoring individualized anesthetic plans for patients, improving safety, and providing patients with educational knowledge and tools in preparation for the surgery day. In the last 2 decades, eHealth and mobile health (mHealth) settings have gradually replaced part of the face-to-face encounters as the platform for preanesthesia communication between doctor and patient, yielding a range of benefits as demonstrated in recent publications. Nevertheless, there is a lack of studies examining the effectiveness of surgical mHealth apps focusing on the pediatric preanesthetic setting and addressing their usability among families. Objective This study describes a dynamic approach for the development process of GistMD’s preanesthesia mHealth system, a mobile-based educational and management system designed for the pediatric setting. Methods The study was conducted in 4 departments at a 1500-bed quaternary, academic medical center in Tel Aviv, Israel. During the study period, the link to the preanesthesia system was sent via SMS text messages to families whose children were about to undergo surgery. The system included preanesthesia questionnaires, educational videos, downloadable instructions, and consent forms. Continuous collection and examination of usability data were conducted during the implementation term including responsiveness, effectiveness, and satisfaction indicators. The information collected in each stage was used to draw conclusions regarding potential usability gaps of the system and to plan product adjustments for the following period. Results During 141 days of implementation, the link to the GistMD preanesthesia management system was sent to 769 families, and product-fit actions were implemented during this term: (1) changing text message scheduling for addressing learnability and accessibility, resulting in a significant increase of 27% (χ21=12.65, P<.001) in view rates and 27.4% (χ21=30.01, P<.001) in satisfaction rates; (2) reducing the number of screens to increase efficiency and operability, leading to a significant decrease of 8.6% in cases where users did not perform any activity on the system after logging in (χ21=6.18, P=.02); (3) conducting a patient-focused campaign in 2 departments aimed at addressing memorability, leading to significant increases in 8 of the 12 usability indicators. Conclusions Our results indicate that mHealth product-fit decisions originating from theory-based approaches and ongoing usability data analysis allow tailoring of the most appropriate responses for usability gaps, as reflected in increased use rates and satisfaction. In the case of the preanesthesia management system in the pediatric setting, increased usability conveyed important benefits for patients and families. This work suggests a framework and study methods that may also be applicable in other mHealth settings and domains.
Effect of Long-Term Hydroxytyrosol Administration on Body Weight, Fat Mass and Urine Metabolomics: A Randomized Double-Blind Prospective Human Study

Hydroxytyrosol (HT) is a natural antioxidant found in olive products and characterized by well-documented beneficial effects on human health. Several research studies are ongoing that aim to investigate its potency and molecular mechanism of action. The present study aimed to investigate the potential effect of HT on human obesity through a randomized double-blind prospective design. HT in two different doses (15 and 5 mg/day) and a placebo capsule was administered to 29 women with overweight/obesity for six months and their weight and fat mass were monitored at three time points (baseline, 4, 12 and 24 weeks). Statistically significant weight and visceral fat mass loss (%weight loss: p = 0.012, %visceral fat loss: p = 0.006) were observed in the group receiving the maximum HT dosage versus placebo after 4 weeks of the intervention, with attenuation of these findings at 12 and 24 weeks of the study. Urine samples were collected during the intervention and analyzed via liquid chromatography–high-resolution mass spectrometry for untargeted metabolomic purposes and comparisons between study groups were performed. HT administration was safe and well-tolerated. To the best of our knowledge, this is the first human cohort investigating the effects of HT on obesity for a prolonged study period.
Taking a Closer Look: Clinical and Histopathological Characteristics of Culture-Positive versus Culture-Negative Pulmonary Mucormycosis

The cultural recovery of Mucorales from hyphae-laden tissue is poor, and the clinical implications of culture positivity are scarcely studied. Therefore, we compared clinical and histopathological characteristics of culture-positive and culture-negative histology-proven pulmonary mucormycosis cases among cancer patients. Histology specimens were blindly reviewed by a thoracic pathologist and graded on four histopathologic features: hyphal quantity, tissue necrosis, tissue invasion, and vascular invasion. Twenty cases with a corresponding fungal culture were identified; five were culture-positive, and fifteen were culture-negative. Although no statistically significant differences were found, culture-positive patients were more likely to exhibit a high burden of necrosis and have a high burden of hyphae but tended to have less vascular invasion than culture-negative patients. In terms of clinical characteristics, culture-positive patients were more likely to have acute myeloid leukemia (60% vs. 27%, p = 0.19), a history of hematopoietic cell transplant (80% vs. 53%, p = 0.31), severe lymphopenia (absolute lymphocyte count ≤ 500/µL, 100% vs. 73%, p = 0.36), and monocytopenia (absolute monocyte count ≤100/µL, 60% vs. 20%, p = 0.11). Forty-two-day all-cause mortality was comparable between culture-positive and culture-negative patients (60% and 53%, p = 0.80). This pilot study represents the first comprehensive histopathological scoring method to examine the relationship between histopathologic features, culture positivity, and clinical features of pulmonary mucormycosis.
INVESTIGATION OF FEASIBLE FLIGHT TRAJECTORIES AND RE-ENTRY ATMOSPHERIC GUIDANCE FOR SPACELINER 7

Preliminary trajectory modellings of the SpaceLiner for the reference mission Australia – Europe, Australia – North America, Europe – North America have been performed. The SpaceLiner 7-3 50 passenger concept has been selected as the reference vehicle for the mission, which consists of three phases namely Ascent phase, Descent Phase and Booster Fly back Phase. Trajectory simulations have been made according to structural and thermal constraints. The reference mission has been defined and trajectories are analyzed in both flight directions with particular attention in the vehicle constraints. Further, off nominal conditions of the SpaceLiner mission have been analyzed and trajectory trade-offs have been considered under degraded vehicle performances. In the presented study three different cases are taken into account: Reduction in performance of engine Isp, reduction in available ascent propellant and the failure of one booster engine at take-off. A simple and innovative control guidance law has been proposed to compute the active controls that govern the descent phase of aerodynamic gliding, which allowed the reduction of trajectories computations and delivers a bank angle profile that should respect the heat constraint. The guidance provides the steering commands for trajectory control from the final condition of the ascent until the TAEM conditions. This design is based on a semi analytic solution of the equations of motion defining the drag acceleration profile referred to specific energy that meets the landing position of the re-entry flight while maintaining the flight within system and operational constraints. Guidance commands are based on a control law that ensures bank angle modulation while the angle-of-attack remains constant.
Factors Associated with Low Back Pain among Nursing Personnel

Introduction: Globally low back pain has been found to affect the quality of peoples’ health hence affecting work output. Higher prevalence of low back pain is reported among nurses which is neglected and responsible for serious suffering and disability and thus affecting quality of patient care. Methods: A descriptive cross-sectional study was conducted at National Medical College and Teaching Hospital Birganj, Nepal among 101 nurses. Ethical approval was obtained from Institutional Review Committee, written informed consent was taken and Semi-structured questionnaire was distributed to the participants for data collection. Data was analyzed by descriptive and inferential statistics. Results: Out of 101 nursing personnel, 79 (78.2%) had experienced low back pain. Half of them 50 (49.5%) had mild pain, 24 (23.8%) had moderate pain whereas only 5 (5%) had severe type of pain. Quebec disability score ranged from 3 to 81 with mean score 25.96 ± 16.41. Majority of the nurses 69 (87.34%) who experienced low back pain did not seek treatment. There was significant association of low back pain and gender(P=.019), performed household work on their own (P=.050) and work experience (P=.007). There was significant association of low back pain with stressful work environment (P=.000) and overtime duties (P=.005). Conclusion: Low back pain is common among nursing personnel, even though most of the nurses did not seek treatment for low back pain which is worrisome and calls for urgent attention to maintain optimal health of these frontline health workers. The factors related to low back pain among nursing professionals is multi-factorial. Key words: Factors, Low Back Pain, Nurses, Quebec disability scale.
Effect of Different Cavity Dimensions and Curing Systems on Cuspal Deflection of some types of Composite Resin Restorations

The cuspal deflection of different composite resin restorations cured with different systems and restoring different cavity dimensions were investigated using a total 60 freshly extracted human maxillary premolars. These teeth were divided into three main equal groups, based upon the tested restorative materials. Group (I) used T-Econpm Plus, Group (A1) (II) used Filtek Z250 XT (A2), and Group (III) used Filtek P90 (A3). Each group was subdivided into two subgroups based upon the prepared cavity dimensions. Each subgroup was further subdivided into two groups whether cured with Halogen (C1), or LED (C2). MOD cavity with two different dimensions, each restorative material was packed according to the manufacturer's instructions and cured. Dye penetration technique was used and specimens were sectioned in mesiodistal direction and examined by stereomicroscope. Collected data was statistically analyzed. The result showed T-Econom plus had statistically significant higher microleakage value, while Filtek P90 had statistically significant lower microleakage value. There was no statistically significant difference between groups cured with Halogen and LED. It can be concluded that silorane based composite, LED curing system, and smaller cavity dimension could significantly decreased cuspal deflection.
Impact of Elevation-Dependent Warming on Runoff Changes in the Headwater Region of Urumqi River Basin

Warming in mountainous areas has obvious elevation dependence (warming rate increases with elevation), which deeply impacts runoff change in mountainous areas. This study analysed the influence of elevation-dependent warming on runoff in the headwater region of the Urumqi River Basin (URB) based on meteorological data, remote sensing images, and runoff data. Results indicated a significant warming rate in the URB from 1960 to 2019 (0.362 °C/decade; p < 0.01). The temperature increased with an obvious elevation-dependent warming in the URB, especially during winter. Glaciers sharply retreated in the headwater region of the URB under regional warming, and remote-based results showed that glacier areas decreased by 29.45 km2 (−57.81%) from the 1960s to 2017. The response of glacier mass balance and meltwater runoff to temperature change has a lag of 3 years in the headwater region of the URB. The elevation-dependent warming of temperature changes significantly impacted glacial meltwater runoff in the URB (R2 = 0.49). Rising temperatures altered the glacial meltwater runoff, and the maximum annual runoff of the Urumqi Glacier No. 1 meltwater runoff increased 78.6% in 1990–2017 compared to 1960–1990. During the period of 1960–1996, the total glacial meltwater runoff amounted to 26.9 × 108 m3, accounting for 33.4% of the total runoff during this period, whereas the total glacial meltwater runoff accounted for 51.1% of the total runoff in 1996–2006. Therefore, these results provide a useful reference for exploring runoff changes in mountainous watersheds in the context of elevation-dependent warming.
Un instrumento de evaluación del aprendizaje para el manejo de catéteres venosos periféricos: adaptación, extensión y validación en español

Nursing practice should be based on available evidence-based practice because of its impact on patient safety in care. Its use should not only be encouraged in professionals but should begin in nursing education. The objective of this study is to translate, adapt, extend and validate a learning assessment instrument in relation to knowledge of peripheral venous catheter management. A two-stage process was followed: 1) translation, adaptation and extension of the instrument; and 2) psychometric testing. The study included 675 nursing students. Cronbach's alpha internal consistency coefficient was 0.703 and the intraclass correlation coefficient was 0.91. The instrument was fairly balanced in terms of difficulty: 46.6% easy items, 13.3% items of medium difficulty and 53.3% of high difficulty. In conclusion, it is a simple instrument to use and to score. The Spanish version has good psychometric properties and provides a valid and reliable instrument for the assessment of knowledge for the management of catheters. La práctica de enfermería debe basarse en la práctica basada en la evidencia disponible debido a su impacto en la atención segura del paciente. Su uso no solo debe fomentarse en los profesionales, sino que debe iniciarse en la formación en enfermería. El objetivo de este estudio se basa en traducir, adaptar y validar un instrumento de evaluación del conocimiento basado en la evidencia científica disponible en relación al manejo de los catéteres venosos periféricos. Se siguió un proceso en dos etapas: 1) traducción, adaptación y ampliación del instrumento; y 2) pruebas psicométricas. El estudio incluyó 675 estudiantes de enfermería. El coeficiente de consistencia interna alfa de Cronbach fue 0,703 y el coeficiente de correlación intraclase de 0.91. El instrumento se presentó bastante equilibrado en cuanto a dificultad: 46,6% de ítems fáciles, 13.3% de ítems de dificultad media y 53.3% de alta dificultad. En conclusión, es un instrumento simple de utilizar y de puntuar. La versión española tiene unas buenas propiedades psicométricas y proporciona un instrumento válido y fiable para la valoración de los conocimientos basados en la evidencia para un manejo óptimo de catéteres venosos periféricos en personas portadoras.
Formulations, Issues and Comparison of Car-Following Models

Microscopic simulation software use car-following models to capture the interaction of a vehicle and the preceding vehicle traveling in the same lane. In the literature, much research has been carried out in the field of car-following and traffic stream modeling. Microscopic car-following models have been characterized by using the relationship between a vehicle’s desired speed and the distance headway (h) between the lead and follower vehicles. On the other hand, macroscopic traffic stream models describe the motion of a traffic stream by approximating for the flow of a continuous compressible fluid. This research work develops and compares three different formulations of carfollowing models – speed formulation, molecular acceleration, and fluid acceleration formulation. First, four state-of-the-art car-following models namely, Van Aerde, Greenshields, Greenberg and Pipes models, are selected for developing the three aforementioned formulations. Then a comprehensive car-following behavior encompassing steady-state conditions and two constraints – acceleration and collision avoidance – is presented. Specifically, the variable power vehicle dynamics model proposed by Rakha and Lucic (2002) is utilized for the acceleration constraint. Subsequently, the thesis describes the issues associated with car-following formulations. Recognizing that many different traffic flow conditions exist, three distinct scenarios are selected for comparison purposes. The results demonstrate that the speed formulation ensures that vehicles typically revert to steady-state conditions when vehicles experience a perturbation from steady-state conditions. On the other hand, both acceleration formulations are unable to converge to steady-state conditions when the system experiences a perturbation from a steady-state. The thesis also attempts to address the question of capacity drop associated with vehicles accelerating from congested conditions. Specifically, the capacity drop proposition is analyzed for the case of a backward recovery (typical of a signalized intersection) and stationary shockwave (typical of a capacity drop on a freeway). In the case of the backward recovery shockwave, the acceleration constraint results in a temporally and spatially confined capacity drop as vehicles accelerate to their desired steady-state speed. This temporally and spatially confined capacity drop results in what is typically termed the start loss of a signalized phase. Subsequently, vehicles attain steady-state conditions, in the case of the speed and molecular acceleration formulations, at the traffic signal stop bar after the initial five vehicle departures. The analysis also demonstrates that after
Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer’s Disease through Network Pharmacology and Computational Methods

The present study involves the integrated network pharmacology and phytoinformatics-based investigation of phytocompounds from Ocimum tenuiflorum against diabetes mellitus-linked Alzheimer’s disease. It aims to investigate the mechanism of the Ocimum tenuiflorum phytocompounds in the amelioration of diabetes mellitus-linked Alzheimer’s disease through network pharmacology, druglikeness and pharmacokinetics, molecular docking simulations, GO analysis, molecular dynamics simulations, and binding free energy analyses. A total of 14 predicted genes of the 26 orally bioactive compounds were identified. Among these 14 genes, GAPDH and AKT1 were the most significant. The network analysis revealed the AGE-RAGE signaling pathway to be a prominent pathway linked to GAPDH with 50.53% probability. Upon the molecular docking simulation with GAPDH, isoeugenol was found to possess the most significant binding affinity (−6.0 kcal/mol). The molecular dynamics simulation and binding free energy calculation results also predicted that isoeugenol forms a stable protein–ligand complex with GAPDH, where the phytocompound is predicted to chiefly use van der Waal’s binding energy (−159.277 kj/mol). On the basis of these results, it can be concluded that isoeugenol from Ocimum tenuiflorum could be taken for further in vitro and in vivo analysis, targeting GAPDH inhibition for the amelioration of diabetes mellitus-linked Alzheimer’s disease.
Vehicle Ride Height Change Due To Radial Expansion Of Tires

Abstract In general, tire deformations caused by wheel rotation are not taken into account when developing vehicle aerodynamics. On the road the tires radially expand as speed increases, which affects the actual ride height of a vehicle. In turn this often increases the real aerodynamic drag compared to values obtained using CFD or a wind tunnel as the mass flow across the relatively rough underbody increases with ground clearance. In this study, on-road ride heights were measured while running a vehicle in a straight line with fixed velocity whilst the aerodynamic lift of the vehicle was determined in a wind tunnel. Subsequently, the relationships between ride height and axle load were obtained by loading the vehicle at standstill with ballast. By comparing the ride heights at high and very low velocities with expected vertical displacement caused purely by aerodynamic lift force as computed according to the ride height - axle load equations, the ride height change due to tire radial expansion was determined.