Miracle-dz/UniFAR-FTUs huggingface dataset:
Numerical Analysis of a Mediterranean ``Hurricane'' over Southeastern Italy

Abstract The presence of a subsynoptic-scale vortex over the Mediterranean Sea in southeastern Italy on 26 September 2006 has been recently documented by the authors. The transit of the cyclone over land allowed an accurate diagnosis of the structure of the vortex, based on radar and surface station data, showing that the cyclone had features similar to those observed in tropical cyclones. To investigate the cyclone in greater depth, numerical simulations have been performed using the Weather Research and Forecasting (WRF) model, set up with two domains, in a two-way-nested configuration. Model simulations are able to properly capture the timing and intensity of the small-scale cyclone. Moreover, the present simulated cyclone agrees with the observational analysis of this case, identifying in this small-scale depression the typical characteristics of a Mediterranean tropical-like cyclone. An analysis of the mechanisms responsible for the genesis, development, and maintenance of the cyclone has also been p.
A holistic perspective to predict yoga tourists’ revisit intention: An integration of the TPB and ECM model

Introduction The purpose of this study is to empirically investigate the pattern of visitors’ revisiting behavioral intention via the innovational approach of Theory of Planned Behavior (TPB) and the Expectation Confirmation Theory (ECT). Methods This research was conducted by data collection with structured questionnaires as its instrument, which was distributed among 420 yoga tourism visitors in two destinations, Mysore and Rishikesh in India. Collected data had been processed by confirmatory factor analysis and structural equation modeling. Results The data analysis results showed that the behavioral attitude of yoga tourism visitors can mediate the influence of behavioral intention through the satisfaction. The findings of this study include the following points: (1) the components of attitude, subjective norm and destination image apply a direct effect on the cultural and spiritual experiences of yoga tourism visitors; (2) cultural and spiritual experiences have a direct effect on the expectation confirmation and the satisfaction of yoga tourism visitors; (3) Expectation confirmation has a direct effect on the satisfaction and the behavior intention of yoga tourism visitors; and (4) Satisfaction has a direct effect on the behavior intention of yoga tourism visitors. Discussion This study contributed by examining the satisfaction and revisit intentions of yoga tourism visitors through an integrated study of planning behavior and expectation confirmation models, which might be refilling the scarcity of research in the tourism literature. The result of this study might offer important implications for scholars, marketers, and tourism industry to better serve this emerging niche market.
CurQ+, a Next-Generation Formulation of Curcumin, Ameliorates Growth Plate Chondrocyte Stress and Increases Limb Growth in a Mouse Model of Pseudoachondroplasia

Mutations in cartilage oligomeric matrix protein (COMP) causes protein misfolding and accumulation in chondrocytes that compromises skeletal growth and joint health in pseudoachondroplasia (PSACH), a severe dwarfing condition. Using the MT-COMP mice, a murine model of PSACH, we showed that pathological autophagy blockage was key to the intracellular accumulation of mutant-COMP. Autophagy is blocked by elevated mTORC1 signaling, preventing ER clearance and ensuring chondrocyte death. We demonstrated that resveratrol reduces the growth plate pathology by relieving the autophagy blockage allowing the ER clearance of mutant-COMP, which partially rescues limb length. To expand potential PSACH treatment options, CurQ+, a uniquely absorbable formulation of curcumin, was tested in MT-COMP mice at doses of 82.3 (1X) and 164.6 mg/kg (2X). CurQ+ treatment of MT-COMP mice from 1 to 4 weeks postnatally decreased mutant COMP intracellular retention, inflammation, restoring both autophagy and chondrocyte proliferation. CurQ+ reduction of cellular stress in growth plate chondrocytes dramatically reduced chondrocyte death, normalized femur length at 2X 164.6 mg/kg and recovered 60% of lost limb growth at 1X 82.3 mg/kg. These results indicate that CurQ+ is a potential therapy for COMPopathy-associated lost limb growth, joint degeneration, and other conditions involving persistent inflammation, oxidative stress, and a block of autophagy.
Estimating Dengue Transmission Intensity in China Using Catalytic Models Based on Serological Data

In recent decades, the global incidence of dengue has risen sharply, with more than 75% of infected people showing mild or no symptoms. Since the year 2000, dengue in China has spread quickly. At this stage, there is an urgent need to fully understand its transmission intensity and spread in China. Serological data provide reliable evidence for symptomatic and recessive infections. Through a literature search, we included 23 studies that collected age-specific serological dengue data released from 1980 to 2021 in China. Fitting four catalytic models to these data, we distinguished the transmission mechanisms by deviation information criterion and estimated force of infection and basic reproduction number (R0), important parameters for quantifying transmission intensity. We found that transmission intensity varies over age in most of the study populations, and attenuation of antibody protection is identified in some study populations; the R0 of dengue in China is between 1.04–2.33. Due to the scarceness of the data, the temporal trend cannot be identified, but data shows that transmission intensity weakened from coastal to inland areas and from southern to northern areas in China if assuming it remained temporally steady during the study period. The results should be useful for the effective control of dengue in China.
Calculated pattern of a vertical antenna with a finite radial‐wire ground system

The appropriate form for the surface impedance of a radial-wire ground screen is utilized to obtain quantitative effects of the important parameters (number of radials, length of radials, wire radius, and ground constants) on the low-angle radiation of a vertical antenna. An approximate correction term is derived to account for currents reflected from the edge of the screen. The effect is small for large screens, but it may be important for smaller screens.
Lobule-Related Action Potential Shape- and History-Dependent Current Integration in Purkinje Cells of Adult and Developing Mice

Purkinje cells (PCs) are the principal cells of the cerebellar cortex and form a central element in the modular organization of the cerebellum. Differentiation of PCs based on gene expression profiles revealed two subpopulations with distinct connectivity, action potential firing and learning-induced activity changes. However, which basal cell physiological features underlie the differences between these subpopulations and to what extent they integrate input differentially remains largely unclear. Here, we investigate the cellular electrophysiological properties of PC subpopulation in adult and juvenile mice. We found that multiple fundamental cell physiological properties, including membrane resistance and various aspects of the action potential shape, differ between PCs from anterior and nodular lobules. Moreover, the two PC subpopulations also differed in the integration of negative and positive current steps as well as in size of the hyperpolarization-activated current. A comparative analysis in juvenile mice confirmed that most of these lobule-specific differences are already present at pre-weaning ages. Finally, we found that current integration in PCs is input history-dependent for both positive and negative currents, but this is not a distinctive feature between anterior and nodular PCs. Our results support the concept of a fundamental differentiation of PCs subpopulations in terms of cell physiological properties and current integration, yet reveals that history-dependent input processing is consistent across PC subtypes.
Corporate Social Responsibility (CSR) and Internal Consequences: The Moderating Role of Employees’ Position Levels

Before understanding customers’ perceptions of hotel CSR, it is important to understand service providers’ responses to hotel CSR because they are the key person to implement the CSR strategy. Therefore, this study investigates the structural relationship among multidimensional CSR performance, attitude, emotions, and resultant behaviors as perceived by hotel employees. In addition, moderating role of employees’ positional levels in the proposed model is evaluated. The findings show that environmental, ethical, and financial/economic domains consisting of hotel CSR performance effectively explain the resultant behaviors that follow. However, social/philanthropic and legal domains do not have considerable effects. The positions held by hotel employees partially moderate the relationships between the proposed constructs. The results of this study add important insights to the existing literature and help hotel practitioners better understand how multidimensional CSR causes positive attitudes, emotions, and behaviors and how the structural model changes depending on the position levels. These results are achieved by using the newly developed hotel CSR measurement scale, which was made through careful and rigorous six-stage procedures.
Spitzer Space Telescope observations of the nucleus of comet 67P/Churyumov-Gerasimenko

Context. Comet 67P/Churyumov-Gerasimenko is the target of the Rosetta mission, and an early characterization of its nucleus is required to assist in preparing the orbital strategy of the spacecraft, the delivery of the Philae surface module and the science operations. We detected the nucleus using the Hubble Space Telescope in March 2003, but had to assume an albedo to derive its size from its observed magnitudes. Aims. It is important to derive an additional constraint for independently determining both the comet size and albedo. Methods. We implemented the well-known “radiometric method”, which combines visible and infrared photometry. Sixteen thermal images of 67P/C-G were obtained by the Multiband Imaging Photometer (MIPS) 24 μ m channel of the Spitzer Space Telescope (SST) on 25 February 2004: the observations spanned a time interval of ~12.5 h, which sampled the rotational light curve of its nucleus. The comet was then outbound at a heliocentric distance of 4.48 AU, at a distance of 4.04 AU from SST, and at a solar phase angle of 12.1°. The nucleus conspicuously appeared as a bright point source superimposed on a dust trail; it was necessary to apply the point-spread function fitting technique using an adequate model of the trail to correctly determine the thermal flux from the nucleus. The data were analyzed using a standard thermal model that incorporated the thermal inertia. Results. Our preferred solution with a low thermal inertia has overall dimensions measured along the principal axis of 4.40–5.20 km, 4.16–4.30 km, and 3.40–3.50 km, corresponding to an effective radius of a sphere with the same volume in the range of 1.93–2.03 km. Larger values of thermal inertia produce larger sizes but the effective radius cannot exceed ~2.3 km. The albedo is in the range 0.039–0.043, remarkably consistent with the canonical value of 0.04 for cometary nuclei. The success of the landing of the Philae surface module remains critically dependent upon the bulk density of the nucleus: it would be safe if close to 0.35 g cm -3 , but a larger value, for instance 0.5 g cm -3 , would present some risks.
A non‐conforming piecewise quadratic finite element on triangles

It is shown in this paper that non-conforming finite elements on the triangle using second-degree polynomials can be easily built and used. Indeed they appear as an ‘enriched’ version of the standard piecewise quadratic six-node element. This work is divided into two parts. In the first we present the basic properties of the element, namely how it can be built and basic error estimates. We also show that this element exhibits a very peculiar regularity property. In the second part we apply our element to the approximation of viscous incompressible flows and more generally to the approximation of incompressible materials.
Finite-Time Stochastic Control for Complex Dynamical Systems: The Estimate for Control Time and Energy Consumption

Controlling complex dynamical systems has been a topic of considerable interest in academic circles in recent decades. While existing works have primarily focused on closed-loop control schemes with infinite-time durations, this paper introduces a novel finite-time, closed-loop stochastic controller that pays special attention to control time and energy and their dependence on system parameters. This technique of stochastic control not only enables finite-time control in chaotic dynamical systems but also facilitates finite-time synchronization in unidirectionally coupled systems. Notably, our new scheme offers several advantages over existing deterministic finite-time controllers from a physical standpoint of time and energy consumption. Using numerical experiments based on random ecosystems, neural networks, and Lorenz systems, we demonstrate the effectiveness of our analytical results. It is anticipated that this proposed stochastic scheme will have widespread applicability in controlling complex dynamical systems and achieving network synchronization.
Direct detection of a magnetic field at the surface of V390 Aurigae – an effectively single active giant

Aims. We have studied the active giant V390 Aur using spectropolarimetry to obtain direct and simultaneous measurements of the magnetic field and the activity indicators in order to infer the origin of the activity. Methods. We used the new spectropolarimeter NARVAL at the Bernard Lyot Telescope (Observatoire du Pic du Midi, France) to obtain a series of Stokes I and Stokes V profiles. Using the LSD technique we were able to detect the Zeeman signature of the magnetic field in each of our 5 observations and to measure its longitudinal component. Using the wide wavelength range of the spectra we could monitor the Call K&H and IR triplet, as well as the H α lines which are activity indicators. The Stokes I LSD profiles enabled us to detect and measure the profiles of two weak stellar companions. Results. From five observations obtained from November 2006 to March 2007, we deduce that the magnetic field has a complex structure which evolves with time and is reminiscent of a dynamo-induced magnetic field. The activity indicators also present day to day variations, but their behaviour does not completely follow the magnetic field variations, because their longitudinal component can cancel the contribution of complex magnetic features. There is a significant difference between the magnetic field observed on November 27, 2006 and on March 15, 2007, at the same rotational phase, but with an interval of 10 rotations. The behaviour of the activity indicators together with the measured enhanced magnetic field on March 15, 2007 support the idea of a change in the field topology. Analysis (RV and EW) of the absorption components of the Stokes I LSD profile shows that the secondary of the visual wide orbit binary ADS 3812 is itself a spectroscopic binary, and suggests that the synchronization effect does not play role for V390 Aur (the primary), and that the giant should be considered as effectively single with regard to its fast rotation and activity.
Effect of Interdental Enamel Reduction on Clinical Attachment Loss, Bleeding on Probing, and Incidence of Caries in Treating Class I Malocclusion Cases: A Retrospective Cohort Study

Introduction Interdental Enamel Reduction (IER) is a clinical procedure that reduces the mesiodistal size of permanent teeth by enamel removal and anatomical re-contouring. The aim of this study was to investigate the effect of IER on patients’ gingival health status, including clinical attachment loss (CAL) and bleeding on probing (BOP). Furthermore, in this study, the incidence of caries after IER with or without fluoride therapy was evaluated. Methods In this retrospective cohort study, 90 patients who had started and completed their orthodontic treatment within the past two years were divided into three groups as follows: In group 1, patients had received interproximal stripping on their anterior mandibular teeth. Patients in group 2 had also received interproximal stripping on their mandibular anterior teeth and topical fluoride had been applied after IER. Patients in group 3 had only received orthodontic treatment without any interproximal stripping. Then, patients were examined for CAL, BOP, and incidence of caries. Results CAL for patients in the IER and control groups were 2.06±0.18 and 2.08±0.16, respectively. Also, BOP for patients in the IER and control groups were 3.01±0.14 and 3.05±0.19, respectively. Incidences of caries, BOP, and CAL were not significantly different between the group of patients who received IER and the control group (P>0.05). Moreover, the incidence of caries was not significantly different between the patients who received topical fluoride after IER and those who did not receive fluoride (P=0.999). Conclusion Interproximal stripping of mandibular anterior teeth before orthodontic treatment does not significantly increase the incidence of caries, BOP, and CAL. Moreover, the application of topical fluoride after IER has no significant effect on the incidence of caries.
Aerodynamic characteristics of a two-dimensional airfoil with ground effect

The effect of Reynolds number on the aerodynamic characteristics of an airfoil with ground effect in viscous flow is investigated by numerical method. A numerical scheme, based on the standard k-e turbulence model, generalized body-fixed coordinates and the finite volume method, is developed to solve the two-dimensional wing-in-ground problem hi viscous flow. The steady, incompressible Navier-Stokes equations are solved using a grid generation program developed by the authors, and the PHOENICS code. Some numerical results are presented to show the effects of Reynolds number, ground clearance, and angles of attack on the aerodynamic characteristics of a NACA 4412 airfoil.
Markov Chain Monte Carlo Estimation of Item Parameters for the Generalized Graded Unfolding Model

The authors present a Markov Chain Monte Carlo (MCMC) parameter estimation procedure for the generalized graded unfolding model (GGUM) and compare it to the marginal maximum likelihood (MML) approach implemented in the GGUM2000 computer program, using simulated and real personality data. In the simulation study, test length, number of response options, and sample size were manipulated. Results indicate that the two methods are comparable in terms of item parameter estimation accuracy. Although the MML estimates exhibit slightly smaller bias than MCMC estimates, they also show greater variability, which results in larger root mean squared errors. Of the two methods, only MCMC provides reasonable standard error estimates for all items.
Modeling and design of proton-implanted ultralow-threshold vertical-cavity laser diodes

Detailed theoretical models are presented and used for investigating the optical, electrical, and thermal characteristics of gain-guided vertical-cavity lasers. A two-dimensional description of current flow in the proton-implanted region is achieved. Heterojunctions are taken into account for the first time, and their influence on current spreading is demonstrated. Thorough finite-element calculations of the temperature profile in the whole device indicate the formation of a thermally induced waveguide. The temperature dependence of threshold current is evaluated, and it is shown that different mode positions greatly influence the output characteristics of the laser. The models are used to analyze the behavior of three-terminal vertical-cavity lasers. Good agreement is obtained between experimental and theoretical results. Using optimized design, record low threshold currents of 650 mu A have been achieved. >
Transplantation of Adipose-Tissue-Engineered Constructs with CRISPR-Mediated UCP1 Activation

Thermogenic adipocytes have potential utility for the development of approaches to treat type 2 diabetes and obesity-associated diseases. Although several reports have proved the positive effect of beige and brown adipocyte transplantation in obese mice, translation to human cell therapy needs improvement. Here, we describe the application of CRISPR activation (CRISPRa) technology for generating safe and efficient adipose-tissue-engineered constructs with enhanced mitochondrial uncoupling protein 1 (UCP1) expression. We designed the CRISPRa system for the activation of UCP1 gene expression. CRISPRa-UCP1 was delivered into mature adipocytes by a baculovirus vector. Modified adipocytes were transplanted in C57BL/6 mice, followed by analysis of grafts, inflammation and systemic glucose metabolism. Staining of grafts on day 8 after transplantation shows them to contain UCP1-positive adipocytes. Following transplantation, adipocytes remain in grafts and exhibit expression of PGC1α transcription factor and hormone sensitive lipase (HSL). Transplantation of CRISPRa-UCP1-modified adipocytes does not influence glucose metabolism or inflammation in recipient mice. We show the utility and safety of baculovirus vectors for CRISPRa-based thermogenic gene activation. Our findings suggest a means of improving existing cell therapy approaches using baculovirus vectors and CRISPRa for modification and transplantation of non-immunogenic adipocytes.
Response of the stratosphere to interannual variability of tropospheric planetary waves

A primitive‐equation global model of the middle atmosphere is used to investigate the response of the extratropical stratosphere to different levels of wave forcing from steady perturbations of the geopotential height near the tropopause. The response of the stratosphere is compared to that in quasi‐geostrophic beta‐plane models used in previous studies.
EYERUBBICS: The Eye Rubbing Cycle Study

Purpose: Describe the cognitive and behavioral symptomatology of patients with chronic ocular rubbing in keratoconus (KC) and Ocular Surface Disease (OSD) using a self-questionnaire. Methods: A prospective study was conducted in a tertiary ophthalmology center between May and July 2021. We consecutively included all patients presenting with one of the following conditions: KC and OSD. A questionnaire including the evaluation of Goodman and CAGE-modified criteria for eye rubbing was given to patients in consultation to evaluate their ocular symptoms and medical background. Results: We included 153 patients in the study. Of these, 125 (81.7%) patients reported eye rubbing. The average Goodman score was 5.8 ± 3.1 and was ≥ 5 in 63.2% of cases. The CAGE score was ≥ 2 in 74.4% of patients. Addiction (p = 0.045) and psychiatric family history (p = 0.03) were more frequent in patients with higher scores. Ocular symptoms and eye rubbing were significantly more frequent and intense in patients with higher scores; Conclusion: Eye rubbing presents addictive-like cognitive and behavioral characteristics in patients with KC or OSD. The eye rubbing cycle could play an essential role in the onset and progression of keratoconus and could be a factor in the maintenance of dry eye.