Miracle-dz/UniFAR-FTUs huggingface dataset:
Day and Night-Time Dehazing by Local Airlight Estimation

We introduce an effective fusion-based technique to enhance both day-time and night-time hazy scenes. When inverting the Koschmieder light transmission model, and by contrast with the common implementation of the popular dark-channel [1], we estimate the airlight on image patches and not on the entire image. Local airlight estimation is adopted because, under night-time conditions, the lighting generally arises from multiple localized artificial sources, and is thus intrinsically non-uniform. Selecting the sizes of the patches is, however, non-trivial. Small patches are desirable to achieve fine spatial adaptation to the atmospheric light, but large patches help improve the airlight estimation accuracy by increasing the possibility of capturing pixels with airlight appearance (due to severe haze). For this reason, multiple patch sizes are considered to generate several images, that are then merged together. The discrete Laplacian of the original image is provided as an additional input to the fusion process to reduce the glowing effect and to emphasize the finest image details. Similarly, for day-time scenes we apply the same principle but use a larger patch size. For each input, a set of weight maps are derived so as to assign higher weights to regions of high contrast, high saliency and small saturation. Finally the derived inputs and the normalized weight maps are blended in a multi-scale fashion using a Laplacian pyramid decomposition. Extensive experimental results demonstrate the effectiveness of our approach as compared with recent techniques, both in terms of computational efficiency and the quality of the outputs.
Metabolic Responses to 24-Hour Fasting and Mild Cold Exposure in Overweight Individuals Are Correlated and Accompanied by Changes in FGF21 Concentration

A greater decrease in 24-h energy expenditure (24 EE) during 24-h fasting defines a “thriftier” metabolic phenotype prone to weight gain during overfeeding and resistant to weight loss during caloric restriction. As the thermogenic response to mild cold exposure (COLD) may similarly characterize this human phenotype identified by acute fasting conditions, we analyzed changes in 24 EE and sleeping metabolic rate (SLEEP) in a whole-room indirect calorimeter during 24-h fasting at thermoneutrality (24°C) and during energy balance both at thermoneutrality (24°C) and mild cold (19°C) in 20 healthy volunteers (80% male; aged 36.6 ± 11.4 years; percentage body fat 34.8 ± 10.5%). Greater decrease in 24 EE during fasting (thriftier phenotype) was associated with less increase in 24 EE during COLD (i.e., less cold-induced thermogenesis). Greater decreases in plasma fibroblast growth factor 21 (FGF21) after 24-h fasting and after COLD were highly correlated and associated with greater decreases in SLEEP in both conditions. We conclude that the metabolic responses to short-term fasting and COLD are associated with and mediated by the liver-derived hormone FGF21. Thus, the 24 EE response to COLD further identifies the “thrifty” versus “spendthrift” phenotype, providing an additional setting to investigate the physiological mechanisms underlying the human metabolic phenotype and characterizing the individual susceptibility to weight change.
Exercise-Induced Premature Ventricular Contractions Are Associated With Myocardial Ischemia Among Asymptomatic Adult Male Firefighters: Implications for Enhanced Risk Stratification

Background: Exercise-induced premature ventricular contractions (EI-PVCs) are associated with an increased risk of cardiovascular disease among asymptomatic adult males, but the underlying mechanisms remain understudied. Myocardial ischemia due to cardiovascular disease reduces coronary blood flow, may impair exercise performance, and initiates EI-PVCs; thus, EI-PVCs may be an early indicator of cardiovascular disease. Objective: The objective of this study was to determine whether EI-PVCs are associated with myocardial ischemia and reduced exercise performance among asymptomatic adult firefighters. Methods: Asymptomatic adult firefighters free of known cardiovascular disease underwent exercise treadmill testing. A 12-lead electrocardiography was placed on participants for 24 hr afterward to measure EI-PVCs in recovery. Univariate and multivariate binary logistic regression models were used to assess the odds of myocardial ischemia. Sensitivity and specificity analyses were conducted. Statistical significance was set at p < . 05. Results: Participants comprised 86 asymptomatic adult males. The prevalence of myocardial ischemia was 30.8%. A single EI-PVC was associated with myocardial ischemia (χ2 = 8.98; p = .003). EI-PVC remained a significant predictor despite adjustment for other cardiovascular risks (odds ratio = 4.281, p = .038). Although not statistically significant, the EI-PVC group achieved lower total exercise time (11.4 ± 2.9 vs. 12.4 ± 3.0 min, p = .13), lower metabolic equivalent of tasks (METs; 11.6 ± 2.6 vs. 12.8 ± 2.3 METs, p = .06), and a lower maximum exercise speed (4.4 ± 0.7 vs. 4.7 ± 0.8 miles/hr, p = .07). Discussion: EI-PVCs are associated with myocardial ischemia among asymptomatic male firefighters, providing additional evidence of the association between EI-PVCs and myocardial ischemia and suggesting EI-PVCs as an early indicator of cardiovascular disease.
Inhaled corticosteroids and COVID-19: a systematic review and clinical perspective

The current coronavirus 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection, raises important questions as to whether pre-morbid use or continued administration of inhaled corticosteroids (ICS) affects the outcomes of acute respiratory infections due to coronavirus. Many physicians are concerned about whether individuals positive for SARS-CoV-2 and taking ICS should continue them or stop them, given that ICS are often regarded as immunosuppressive. A number of key questions arise. Are people with asthma or COPD at increased risk of developing COVID-19? Do ICS modify this risk, either increasing or decreasing it? Do ICS influence the clinical course of COVID-19? (figure 1). Whether ICS modify the risk of developing COVID-19 or the clinical course of COVID-19 in people who do not have lung disease should also be considered (figure 1). There is no evidence on benefits or harms of inhaled steroids in COVID-19. It is essential that epidemiological studies of COVID-19 include detailed information on comorbidities and prior medication to help answer this question. https://bit.ly/2XVwIsa
Reflections on Modeling Poliovirus Transmission and the Polio Eradication Endgame

The Global Polio Eradication Initiative (GPEI) partners engaged modelers during the past nearly 20 years to support strategy and policy discussions and decisions, and to provide estimates of the risks, costs, and benefits of different options for managing the polio endgame. Limited efforts to date provided insights related to the validation of the models used for GPEI strategy and policy decisions. However, modeling results only influenced decisions in some cases, with other factors carrying more weight in many key decisions. In addition, the results from multiple modeling groups do not always agree, which supports selection of some strategies and/or policies counter to the recommendations from some modelers but not others. This analysis reflects on our modeling, and summarizes our premises and recommendations, the outcomes of these recommendations, and the implications of key limitations of models with respect to polio endgame strategy. We briefly review the current state of the GPEI given epidemiological experience as of early 2020, which includes failure of the GPEI to deliver on the objectives of its 2013–2018 strategic plan despite full financial support. Looking ahead, we provide context for why the GPEI strategy of global oral poliovirus vaccine (OPV) cessation to end all cases of poliomyelitis looks infeasible given the current state of the GPEI and the failure to successfully stop all transmission of serotype 2 live polioviruses within four years of the April–May 2016 coordinated cessation of serotype 2 OPV use in routine immunization.
Intravenous Enzyme Replacement Therapy in Mucopolysaccharidoses: Clinical Effectiveness and Limitations

The aim of this review is to summarize the evidence on efficacy, effectiveness and safety of intravenous enzyme replacement therapy (ERT) available for mucopolysaccharidoses (MPSs) I, II, IVA, VI and VII, gained in phase III clinical trials and in observational post-approval studies. Post-marketing data are sometimes conflicting or controversial, possibly depending on disease severity, differently involved organs, age at starting treatment, and development of anti-drug antibodies (ADAs). There is general agreement that ERT is effective in reducing urinary glycosaminoglycans and liver and spleen volume, while heart and joints outcomes are variable in different studies. Effectiveness on cardiac valves, trachea and bronchi, hearing and eyes is definitely poor, probably due to limited penetration in the specific tissues. ERT does not cross the blood–brain barrier, with the consequence that the central nervous system is not cured by intravenously injected ERT. All patients develop ADAs but their role in ERT tolerance and effectiveness has not been well defined yet. Lack of reliable biomarkers contributes to the uncertainties about effectiveness. The data obtained from affected siblings strongly indicates the need of neonatal screening for treatable MPSs. Currently, other treatments are under evaluation and will surely help improve the prognosis of MPS patients.
Big Data and Predictive Analytics in Fire Risk Using Weather Data

The objective of this article is to study the impact of weather on the damage caused by fire incidents across the United States. The article uses two sets of big data—‐fire incidents data from the National Fire Incident Reporting System (NFIRS) and weather data from the National Oceanic and Atmospheric Administration (NOAA)—to obtain a single comprehensive data set for prediction and analysis of fire risk. In the article, the loss is referred to as “Total Percent Loss,” a metric that is calculated based on the content and property loss incurred by an owner over the total value of content and property. Gradient boosting tree (GBT), a machine learning algorithm, is implemented on the processed data to predict the losses due to fire incidents. An R2 value of 0.933 and mean squared error (MSE) of 124.641 out of 10,000 signify the extent of high predictive accuracy obtained by implementing the GBT model. In addition to this, an excellent predictive performance demonstrated by the GBT model is further validated by a strong fitting between the predicted loss and the actual loss for the test data set, with an R2 value of 0.97. While analyzing the influence of each input variable on the output, it is observed that the state in which a fire incident takes place plays a major role in determining fire risk. This article provides useful insights to fire managers and researchers in the form of a detailed framework of big data and predictive analytics for effective management of fire risk.
EARLY AND LATE MACULAR CHANGES AFTER THE INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR A FULL-THICKNESS MACULAR HOLE.

PURPOSE To describe the anatomic evolution of full-thickness macular hole closure after the inverted internal limiting membrane (ILM) flap technique. METHODS A retrospective review of 39 eyes (38 patients) with a full-thickness macular hole treated with the inverted ILM flap technique was performed. Ophthalmic examinations and imaging were performed preoperatively and postoperatively. RESULTS Macular changes in the early postoperative period included flap closure (15.4%), U-shaped closure (17.9%), V-shaped closure (33.3%), W-shaped closure (28.2%), gap closure (2.6%), and gap open (2.6%). Flap closure was associated with low myopia and shorter axial length (P < 0.05). Two types of flap closure were observed. Type 1 was characterized by gap opening with an ILM cap, followed by a thickened ILM band drawing the edges of the macular hole closer with subsequent external limiting membrane formation; Type 2 was characterized by gap closure with an ILM cap, followed by gliotic proliferation filling the gap. Flap closure configuration disappeared within 4 months postoperatively. At the last follow-up, foveal contours were U-shaped closure (25.6%), V-shaped closure (35.9%), W-shaped closure (35.9%), and gap open (2.6%). CONCLUSION Two types of flap closure were observed in the early postoperative period. Several patterns of the foveal contour were observed in the late period. The presence of the ILM flap predicts eventual hole closure. These findings require confirmation and further elucidation of their possible clinical significance.
Natural products may interfere with SARS-CoV-2 attachment to the host cell

Abstract SARS-CoV-2 has been emerged in December 2019 in China, causing deadly (5% mortality) pandemic pneumonia, termed COVID-19. More than one host-cell receptor is reported to be recognized by the viral spike protein, among them is the cell-surface Heat Shock Protein A5 (HSPA5), also termed GRP78 or BiP. Upon viral infection, HSPA5 is upregulated, then translocating to the cell membrane where it is subjected to be recognized by the SARS-CoV-2 spike. In this study, some natural product compounds are tested against the HSPA5 substrate-binding domain β (SBDβ), which reported to be the recognition site for the SARS-CoV-2 spike. Molecular docking and molecular dynamics simulations are used to test some natural compounds binding to HSPA5 SBDβ. The results show high to a moderate binding affinity for the phytoestrogens (Diadiazin, Genistein, Formontein, and Biochanin A), chlorogenic acid, linolenic acid, palmitic acid, caffeic acid, caffeic acid phenethyl ester, hydroxytyrosol, cis-p-Coumaric acid, cinnamaldehyde, thymoquinone, and some physiological hormones such as estrogens, progesterone, testosterone, and cholesterol to the HSPA5 SBDβ. Based on its binding affinities, the phytoestrogens and estrogens are the best in binding HSPA5, hence may interfere with SARS-CoV-2 attachment to the stressed cells. These compounds can be successful as anti-COVID-19 agents for people with a high risk of cell stress like elders, cancer patients, and front-line medical staff. Communicated by Ramaswamy H. Sarma Graphical Abstract
Effect of β-carotene and canthaxanthin on the immune responses of the rat

: Male Wistar Kyoto rats were fed diets containing either 2 g/kg (0.2%) beta-carotene, canthaxanthin or basal diet for up to 66 wk. Plasma and tissues were analyzed for vitamin A, vitamin E, beta-carotene or canthaxanthin levels. In vitro immune responses of splenocytes to T- and B-lymphocyte mitogens were determined. T- and B-lymphocyte responses were consistently enhanced in the groups fed beta-carotene or canthaxanthin. Since canthaxanthin cannot be converted to vitamin A, the immunoenhancement seen in these experiments is attributed to a carotenoid effect.
Genetic variability and structure of an important wild steppe grass Psathyrostachys juncea (Triticeae: Poaceae) germplasm collection from north and central Asia

Russian wildrye, Psathyrostachys junceus (Fisch.) Nevski, is an important wild steppe perennial grass, which is characterized by longevity and short robust rhizomes. It also has highly resistance in grazing and abiotic stress. In this study, the genetic diversity of eleven P. juncea wild germplasms from north and central Asia was investigated using AFLP markers. The P. juncea populations were divided into three clades in both UPGMA dendrogram and PCoA clustering corresponding to the three genetic memberships in STRUCTURE analysis. The genetic specificity of Xinjiang (XJ) populations was revealed by the highest Ne (1.5411) and Hj (0.3553) and their dispersion shown in UPGMA. High inbreeding coefficient (Wright’s F statistics, f = 0.496, Fst = 0.128) was observed although a moderate degree of gene flow (Nm = 1.4736) existed, that may ascribe to habitat fragmentation or the low seedling recruitment, which ultimately resulted in decrease of population size and their genetic diversity. The key factors inducing moderate genetic differentiation detected in this study were isolation by distance (IBD), climatic variabilities and geographical barriers. All these results provide insights into the study of genetic status and germplasm collecting of Russian wildrye.
Superhigh flexibility and out-of-plane piezoelectricity together with strong anharmonic phonon scattering induced extremely low lattice thermal conductivity in hexagonal buckled CdX (X = S, Se) monolayers

Although CdX (X = S, Se) has been mostly studied in the field of photocatalysis, photovoltaics, their intrinsic properties, such as, mechanical, piezoelectric, electron and phonon transport properties have been completely overlooked in buckled CdX monolayers. Ultra-low lattice thermal conductivity [1.08 W m−1 K−1 (0.75 W m−1 K−1)] and high p-type Seebeck coefficient [1300 μV K−1 (850 μV K−1)] in CdS (CdSe) monolayers have been found in this work based on first-principles DFT coupled to semi-classical Boltzmann transport equations, combining both the electronic and phononic transport. The dimensionless thermoelectric figure of merit is calculated to be 0.78 (0.5) in CdS (CdSe) monolayers at room temperature, which is comparable to that of two-dimensional (2D) tellurene (0.8), arsenene and antimonene (0.8), indicating its great potential for applications in 2D thermoelectrics. Such a low lattice thermal conductivity arise from the participation of both acoustic [91.98% (89.22%)] and optical modes [8.02% (10.78%)] together with low Debye temperature [254 K (187 K)], low group velocity [4 km s−1 (3 km s−1)] in CdS (CdSe) monolayers, high anharmonicity and short phonon lifetime. Substantial cohesive energy (∼4–5 eV), dynamical and mechanical stability of the monolayers substantiate the feasibility in synthesizing the single layers in experiments. The inversion symmetry broken along the z direction causes out-of-plane piezoelectricity. |d33| ∼ 21.6 pm V−1, calculated in CdS monolayer is found to be the highest amongst structures having atomic-layer thickness. Superlow Young’s modulus ∼41 N m−1 (31 N m−1) in CdS (CdSe) monolayers, which is comparable to that of planar CdS (29 N m−1) and TcTe2 (34 N m−1), is an indicator of its superhigh flexibility. Direct semiconducting band gap, high carrier mobility (∼500 cm2 V−1 s−1) and superhigh flexibility in CdX monolayers signify its gigantic potential for applications in ultrathin, stretchable and flexible nanoelectronics. The all-round properties can be synergistically combined together in futuristic applications in nano-piezotronics as well.
Astaxanthin Treatment Induces Maturation and Functional Change of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells which accumulate in stress conditions such as infection and tumor. Astaxanthin (ATX) is a well-known antioxidant agent and has a little toxicity. It has been reported that ATX treatment induces antitumor effects via regulation of cell signaling pathways, including nuclear factor erythroid-derived 2-related factor 2 (Nrf2) signaling. In the present study, we hypothesized that treatment with ATX might induce maturation of MDSCs and modulate their immunosuppressive activity. Both in vivo and in vitro treatment with ATX resulted in up-regulation of surface markers such as CD80, MHC class II, and CD11c on both polymorphonuclear (PMN)-MDSCs and mononuclear (Mo)-MDSCs. Expression levels of functional mediators involved in immune suppression were significantly reduced, whereas mRNA levels of Nrf2 target genes were increased in ATX-treated MDSCs. In addition, ATX was found to have antioxidant activity reducing reactive oxygen species level in MDSCs. Finally, ATX-treated MDSCs were immunogenic enough to induce cytotoxic T lymphocyte response and contributed to the inhibition of tumor growth. This demonstrates the role of ATX as a regulator of the immunosuppressive tumor environment through induction of differentiation and functional conversion of MDSCs.
Understanding the role of zinc in IL-1β production

Zinc is an essential biological trace element required for proper immune functioning. Zinc deficient individuals have been reported to suffer compromised immune responses and increased levels of inflammatory cytokines. Inflammation is integral to the pathology of many disease states, ranging from pathogen dependent infectious disease to non-infectious disease such as cancer, heart disease, diabetes and stroke. One of the main mediators of inflammation is the pro-inflammatory cytokine interleukin-1beta (IL-1beta). Production of IL-1beta occurs via a two step process; firstly the transcription of an inactive pro-form is initiated, followed by protease activation leading to the cleavage of IL-1beta to a mature form. Here it is shown that in vitro zinc depletion of macrophages, using the zinc chelators TPEN and DTPA, leads to pro-IL-1beta cleavage and furthermore to increased release of active IL-1beta. This would suggest that zinc depletion induces activation of proteases that cleave IL-1beta. Caspase-1, ASC, PP2A, cathepsin B and cathepsin G are all shown to regulate zinc depletion-induced IL-1beta release in macrophages. The cell death proteins XIAP and caspase-8 have also been identified to be regulated by zinc depletion in macrophages and there is literature to suggest that these proteins may contribute to IL-1beta processing and release. By identifying a role for zinc depletion in IL-1beta processing we move closer to identifying potential therapeutic targets for zinc deficiency induced inflammatory disease. Zinc also has regulatory roles in the expression of IL-1beta. Here a systems biology approach is utilised to create an explicit representation of the pathways involved in IL-1beta expression. In many in vivo and in vitro models, transcription of pro-Interleukin-1beta is induced by the gram negative cell wall component lipopolysaccharide (LPS). A systematically curated network map of IL-1 transcription has been created. The map encompasses interactions at the macrophage cell membrane, where LPS binds Toll-like receptor 4 (TLR4); the resulting cytoplasmic signalling cascades, including MAPK and NF-kappaB; and finally the specific transcription factor interactions in the nucleus. By creating this model we aim to enable the production of dynamic models of IL-1 transcription.