Miracle-dz/UniFAR-FTUs huggingface dataset:
Steps for conducting a valid hydraulic fracturing laboratory test

Several parameters are involved in a hydraulic-fracturingoperation, which is a technique used mainly in tight formations to enhance productivity. Formation properties, state of stresses in the field, injecting fluid characteristics, and pumping rate are among several parameters that can influence the process. Numerical analysis is conventionally run to simulate the hydraulic-fracturing process. Before operating the expensive fracturing job in the field, however, it would be useful to understand the effect of various parameters by conducting physical experiments in the lab. Laboratory experiments are also valuable for validating the numerical simulations. Applying the scaling laws, which are to correspond to the field operation with the test performed in the lab, are necessary to draw valid conclusions from the experiments. Dimensionless parameters are introduced through the scaling laws that are used to scale-down different parameters including the hole size, pump rate and fluid viscosity to that of the lab scale. Sample preparation and following a consistent and correct test procedure in the lab, however, are two other important factors that play a substantial role in obtaining valid results. The focus of this peer-reviewed paper is to address the latter aspect; however, a review of different scaling laws proposed and used will be given. The results presented in this study are the lab tests conducted using a true triaxial stress cell (TTSC), which allows simulation of hydraulic-fracturing under true field stress conditions where three independent stresses are applied to a cubic rock sample.
A Fully Coupled Time-Domain BEM-FEM Method for the Prediction of Symmetric Hydroelastic Responses of Ships with Forward Speed

This paper presents a direct time-domain method for the prediction of symmetric hydroelastic responses of ships progressing with forward speed in small amplitude waves. A transient time-domain free surface Green function is used for the idealisation of the seakeeping problem using an Earth fixed coordinate system. Free surface ship hydrodynamics are idealised in the time domain by a Green function, and forward speed effects are idealised by a space-state model. Modal actions are accounted for by Timoshenko beam structural dynamics. Flexible fluid structure interaction (FFSI) coupling is enabled by a body boundary condition, and a direct integration Newmark- β scheme is used to obtain symmetric dynamic responses. The method is validated against available published numerical and experimental results. A parametric study for different container ship hull forms confirms that (i) forward speed effects should be taken under consideration as far as practically possible and (ii) hull flexibility effects accounting for hull shear deformation and rotary inertia are more notable for slender hull forms.
PTBP1 is a Novel Poor Prognostic Factor for Glioma

Objective Polypyrimidine tract-binding protein 1 (PTBP1) is an RNA-binding protein, which plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. However, little was known about the correlation between PTBP1 and glioma and its prognostic significance in glioma patients. Our aim was to investigate the expression, functional role, and prognostic value of PTBP1 in glioma. Methods We explored the expression of PTBP1 protein using immunohistochemistry in 150 adult malignant glioma tissues and 20 normal brain tissues and evaluated its association with clinicopathological parameters by chi-square test. Kaplan-Meier method was used to evaluate the prognostic effect of PTBP1 in glioma. Univariate/multivariate Cox analyses were used to identify independent prognostic factors. Transcriptional regulation network was constructed based on differentially expressed genes (DEGs) of PTBP1 from TCGA/CGGA database. GO and KEGG enrichment analyses were used to explore the function and pathways of DEGs. Results Out of the 150 malignant glioma tissues (60 LGG and 90 GBMs) and 20 normal brain tissues in our cohort, PTBP1 protein was high expressed in glioma tissues (79/150, 52.7%), but no expression was detected in normal brain tissues (0/20, 0%). The expression of PTBP1 was significantly higher in GBMs (P < 0.001). More than half of GBMs (62/90, 68.9%) were PTBP1 high expression. Chi-square test showed that the expression of PTBP1 was correlated with patient age, WHO grade, Ki-67 index, and IDH status. High expression of PTBP1 was significantly associated with poor prognosis in glioma, and it was an independent risk factor in glioma patients. Furthermore, we shed light on the underlying mechanism of PTBP1 by constructing a miR-218-TCF3-PTBP1 transcriptional network in glioma. Conclusion PTBP1 was high expressed in glioma, and it significantly correlated with poor prognosis, suggesting a potential therapeutic target for glioma, particularly for GBM.
Effects of STEAM Lessons Using Scratch Programming Regarding Small Organisms in Elementary Science-Gifted Education

본 연구의 목적은 스크래치 프로그래밍을 활용한 초등과학 ‘작은 생물’ STEAM 수업을 개발하고 적용하여, 초등 영재학생의 창의적 인성, 창의적 문제해결력, 과학적 태도의 향상에 어떠한 영향을 미치는지 알아보고자 하였다. 개발한 STEAM 수업은 과학 지식과 스크래치 프로그래밍을 통합한 내용적 융합의 방법을 통해 학습자가 창의적 설계와 감성적 체험을 효과적으로 경험할 수 있도록 설계되었다. 연구대상은 26명의 초등과학 영재학생들이었으며, 양적 및 질적 접근을 통해 자료를 수집하였다. 7차시의 수업을 적용한 결과, 개발한 STEAM 수업이 창의적 인성 및 과학적 태도에 효과가 있었다. 창의적 인성 하위 요소 중, 독립성에서 효과가 있었으며, 과학적 태도 측면에서는 자발성 및 인내심에서 유의한 상승을 보였다. 본 연구는 생명 과학 및 컴퓨터 프로그래밍처럼 STEAM 수업을 위한 효과적인 수단을 통합하는 일이 과학 기술에 대한 학생들의 창의성과 흥미를 신장시킬 수 있음을 제안한다. 주요어 : STEAM, 스크래치, 작은 생물, 창의적 인성, 창의적 문제해결력, 과학적 태도
Gondwana break‐up controlled by tectonic inheritance and mantle plume activity: Insights from Natal rift development (South Mozambique, Africa)

The break‐up of Eastern Gondwana started during the Early Jurassic with the separation of Antarctica and Madagascar from Africa. While margins architecture has been described along the Western Somalia Basin and the Central Mozambique, the spatial extent of rifting further south—i.e. the Natal Valley—remains poorly documented. Seismic reflection profiles interpretation, 40Ar/39Ar ages and isotopic data show the existence of a plume‐related magma‐rich margin—the Natal segment—characterized by a large volume of seaward dipping reflectors inferred to be basalts. In particular, the contrast in lithosphere rheology, probably caused by a Meso‐Neoproterozoic belt between the Kaapval and Grunehogna Archean cratons, favoured extension and upwelling from a deep mantle thermomechanical anomaly, the so‐called Karoo superplume that started at around 180 Ma. Furthermore, the presence of stretched continental crust at around 30°S implies a more southerly position of Antarctica which will need to be considered in future kinematic models.
Quasi-static Optical Control of In-plane Actuated, Deformable Mirror: Experimental Comparison with Finite Element Analysis

Future space telescopes may use large diameter (20-meter plus), ∞exible, lightweight membrane-like optical quality mirrors to overcome launch weight and packaging limitations. In-plane actuators, such as piezoelectric elements embedded within the mirror’s structure, could be used to actively shape these deformable mirrors. Thus, the active deformable mirrors could form commanded conjugate surfaces necessary to remove atmospheric distortions in an incoming wavefront, as well as countering any manufacturing imperfections or space-atmospheric disturbances. A stepping stone to realizing these large scale structures is the creation of laboratory test articles and investigating their behavior. To this end, a flve-inch in-plane actuated, tensioned, deformable mirror was constructed and evaluated for optical level responses. The research presented herein is a comparison of experimental data with advanced flnite element modelling techniques using MSC.Nastran software, and the implementation of control algorithms developed from the results of the flnite element modelling used to achieve optical precision quasi-static shaping of the experimental mirror’s surface.
The SIMO Block Rayleigh Fading Channel Capacity Scaling With Number of Antennas, Bandwidth, and Coherence Length

This paper studies the capacity scaling of non-coherent Single-Input Multiple-Output (SIMO) independent and identically distributed (i.i.d.) Rayleigh block fading channels versus bandwidth (<inline-formula> <tex-math notation="LaTeX">$B$ </tex-math></inline-formula>), number of receive antennas (<inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula>) and coherence block length (<inline-formula> <tex-math notation="LaTeX">$L$ </tex-math></inline-formula>). In non-coherent channels (without Channel State Information–CSI) capacity scales as <inline-formula> <tex-math notation="LaTeX">$\Theta (\min (B,\sqrt {NL},N))$ </tex-math></inline-formula>. This is achievable using Pilot-Assisted signaling. Energy Modulation signaling rate scales as <inline-formula> <tex-math notation="LaTeX">$\Theta (\min (B,\sqrt {N}))$ </tex-math></inline-formula>. If <inline-formula> <tex-math notation="LaTeX">$L$ </tex-math></inline-formula> is fixed while <inline-formula> <tex-math notation="LaTeX">$B$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> grow, the two expressions grow equally and Energy Modulation achieves the capacity scaling. However, Energy Modulation rate does not scale as the capacity with the variable <inline-formula> <tex-math notation="LaTeX">$L$ </tex-math></inline-formula>. The coherent channel capacity with a priori CSI, in turn, scales as <inline-formula> <tex-math notation="LaTeX">$\Theta (\min (B,N))$ </tex-math></inline-formula>. The coherent channel capacity scaling can be fully achieved in non-coherent channels when <inline-formula> <tex-math notation="LaTeX">$L\geq \Theta (N)$ </tex-math></inline-formula>. In summary, the channel coherence block length plays a pivotal role in modulation selection and the capacity gap between coherent and non-coherent channels. Pilot-Assisted signaling outperforms Energy Modulation’s rate scaling versus coherence block length. Only in high mobility scenarios where <inline-formula> <tex-math notation="LaTeX">$L$ </tex-math></inline-formula> is much smaller than the number of antennas (<inline-formula> <tex-math notation="LaTeX">$L\ll \Theta (\sqrt {N})$ </tex-math></inline-formula>), Energy Modulation is effective in non-coherent channels.
Energy absorption in carbon fiber honeycomb structures manufactured using a liquid thermoplastic resin

In this study, carbon fiber/thermoplastic (Elium®) honeycombs were manufactured using the resin infusion process in a customized metallic mold. Honeycomb cores, based on different carbon fiber layers, were manufactured to achieve four different fiber weight fraction composites. Two different types of specimens, based on a single honeycomb cell and five honeycomb cells, were prepared and subjected to compression loading. The results of these tests were compared with data from similar honeycomb structures based on carbon fiber–reinforced epoxy composite. It has been shown that the compressive strength and the specific energy absorption capacity of the honeycombs increase rapidly with increasing fiber weight fraction. The specific energy absorption capability of the novel thermoplastic honeycomb structures has been shown to be as high as 50 kJ/kg which compares favorably with other energy-absorbing core materials. The thermoplastic honeycomb specimens exhibited a similar specific energy absorption capability and an improved compressive strength compared to their epoxy counterparts. Furthermore, the CF/thermoplastic honeycombs exhibited enhanced structural stability and displayed a more uniform and progressive core failure mode than the longitudinal splitting observed in the CF/epoxy honeycombs. The honeycomb core that exhibited the best performance was then used to manufacture thermoplastic sandwich specimens based on CF/thermoplastic face sheets. Three point bend tests were conducted to determine the flexural strength of the sandwich samples and to identify the failure modes. Optical micrographs revealed that the flexural damage was primarily due to the core crushing and adhesive failure between the core and the composite skins.
The Hodgkin Lymphoma Immune Microenvironment: Turning Bad News into Good

Simple Summary Classic Hodgkin lymphoma (cHL) is one of the most enigmatic study models of the tumor microenvironment (TME), in which the Hodgkin–Reed Sternberg (HRS) cells are distributed throughout an abundant but ineffective immune ecosystem. The hyperactivation of HRS cells due to somatic mutations leads to complex interactions with the different subsets of immune cell populations, modeling the pathophysiology of the disease. There are remaining loose ends regarding the identification of the immune functional states in the cHL microenvironment and their influence on tumor cell survival. Here, we review the most relevant immune populations identified in the cHL context, focusing on integrative functional signatures. Abstract The classic Hodgkin lymphoma (cHL) tumor microenvironment (TME) is by far the most abundant component of tumors and is responsible for most of their biological and clinical characteristics. Recent advances in our knowledge of these networks in cellular interactions allow us to understand that the neoplastic Hodgkin and Reed Sternberg (HRS) cells, although they are in the minority, are the main architects of this dysregulated immune milieu. Here, we review the major changes that have happened in recent years: from TME as a helpless bystander, reflecting an ineffective immune response, to a dynamic tumor-promoting and immunosuppressive element. The HRS cells promote survival through interconnected intrinsic and extrinsic alterations, boosting pro-tumoral signaling pathways through genetic aberrations and autocrine growth signals, in parallel with abnormal cytokine secretion for the recruitment and selection of the best cell partners for this immunosuppressive TME. In turn, cHL is already proving to be the perfect model with which to address an immune checkpoint blockade. Preliminary data demonstrate the utility of druggable key signaling pathways in this ensemble, such as JAK-STAT, NF-κB, and others. In addition, myriad biomarkers predicting a response await validation by new in situ multiplex analytical methods, single-cell gene expression, and other techniques. Together, these components will define the functional phenotypes with which we will elucidate the molecular pathogenesis of the disease and improve the survival of patients who are refractory to conventional therapies.
Robotic process automation and audit quality

This study aims to explain the Jordanian state of the implementation of robotic process automation RPA in auditing, and to examine the expected impact of RPA implementation on audit quality from the views of Jordanian auditors, furthermore, the study aims to define the challenges of RPA implementation in Jordanian auditing firms. The study employed a survey method to collect data by using questionnaires. Three hundred (300) questionnaires were supplied to the sample of the study of which two hundred and seven (207) questionnaires from retrieved questionnaires were valid for analysis. The results of the study showed that Jordanian auditing firms do not apply RPA despite the expected impact of implementation on audit quality, this may be justified by the challenges that the auditors believe, the most important as they indicated are the initial investment for creating or purchase RPA, and the changing resistant by auditors for different purposes. The contributions of this paper are by enriching the theoretical side by shedding light on RPA and knowing the state of RPA implementation in Jordanian auditing firms and examining the impact of RPA implementation on the quality of audit. This paper also identifies the main challenges of the implementation of RPA in the Jordanian environment.
A longitudinal analysis of the growth rate and mass of tail feathers in a great tit population: ontogeny, genetic effects and relationship between both traits

© 2022 The Authors. Journal of Avian Biology published by John Wiley & Sons Ltd on behalf of Nordic Society Oikos This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Subject Editor: Judith Morales Editor-in-Chief: Jan-Åke Nilsson Accepted 31 January 2022 doi: 10.1111/jav.02894 1–12
Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium–Pilocarpine Model of Temporal Lobe Epilepsy

Preventing epileptogenesis in people at risk is an unmet medical need. Metabotropic glutamate receptors (mGluRs) are promising targets for such therapy. However, drugs acting on mGluRs are not used in the clinic due to limited knowledge of the involvement of mGluRs in epileptogenesis. This study aimed to analyze the changes in gene expression of mGluR subtypes (1–5, 7, 8) in various rat brain regions in the latent and chronic phases of a lithium–pilocarpine model of epilepsy. For this study, multiplex test systems were selected and optimized to analyze mGluR gene expression using RT-qPCR. Region- and phase-specific changes in expression were revealed. During the latent phase, mGluR5 mRNA levels were increased in the dorsal and ventral hippocampus, and expression of group III genes was decreased in the hippocampus and temporal cortex, which could contribute to epileptogenesis. Most of the changes in expression detected in the latent stage were absent in the chronic stage, but mGluR8 mRNA production remained reduced in the hippocampus. Moreover, we found that gene expression of group II mGluRs was altered only in the chronic phase. The study deepened our understanding of the mechanisms of epileptogenesis and suggested that agonists of group III mGluRs are the most promising targets for preventing epilepsy.
Software update: The ORCA program system—Version 5.0

Version 5.0 of the ORCA quantum chemistry program suite was released in July 2021. ORCA 5.0 represents a major improvement over all previous versions of ORCA and features (1) highly improved performance, (2) increased numerical robustness, (3) a host of new functionality, and (4) greatly improved user friendliness. The article describes the most salient features of the program.
Examining racial discourse in equity reports: Florida’s public Hispanic serving institutions

Public Hispanic serving institutions (HSIs) play a prominent role in educating racially minoritized students, thus making them valuable sites for examining higher education increased attention to state and institution-level diversity policy and plans. Institutional diversity, equity, and inclusion (DEI) plans, serve as public statements regarding institutional priorities, illuminate how racial equity is centered or decentered. This research engages 10 Equity Reports at public two-year and four-year HSIs in Florida. Through the lens of critical race theory and LatCrit, the analysis foregrounds patterns regarding institutional discourse, in response to state policy mandates, considering the intersection of HSI designation and institutional type. The findings illustrate how the Equity Reports decenter racial equity, reflect a sparse substantive mention of Latinx students, and only superficially engages with the HSIs designation. The findings expand the analysis of HSIs to a new sociopolitical context, providing a broader view of HSIs, and provide policymakers and implementers with tools to consider racial equity through DEI policy.
Synthesis and Solvent Dependent Fluorescence of Some Piperidine-Substituted Naphthalimide Derivatives and Consequences for Water Sensing

Novel fluorescent strigolactone derivatives that contain the piperidine-substituted 1,8-naphthalimide ring system connected through an ether link to a bioactive 3-methyl-furan-2-one unit were synthesized and their spectroscopic properties investigated. The solvatochromic behavior of these piperidine-naphthalimides was monitored in solvents of different polarity using the electronic absorption and fluorescence spectra. These compounds exhibited a strong positive solvatochromism taking into account the change of solvent polarity, and the response mechanism was analyzed by fluorescence lifetime measurements. According to Catalan and [f(n), f(ε), β, α] solvent scales, the dipolarity and polarizability are relevant to describe the solute–solvent interactions. The emission chemosensing activity was discussed in order to determine the water content in organic environments. The emission intensity of these compounds decreased rapidly in dioxane, increasing water level up to 10%. Measuring of quantum yield indicated that the highest values of quantum efficiency were obtained in nonpolar solvents, while in polar solvents these derivatives revealed the lowest quantum yield. The fluorescence decay can be described by a monoexponential model for low water levels, and for higher water contents a biexponential model was valid.
Visual Mismatch Negativity Reflects Enhanced Response to the Deviant: Evidence From Event-Related Potentials and Electroencephalogram Time-Frequency Analysis

Automatic detection of information changes in the visual environment is crucial for individual survival. Researchers use the oddball paradigm to study the brain’s response to frequently presented (standard) stimuli and occasionally presented (deviant) stimuli. The component that can be observed in the difference wave is called visual mismatch negativity (vMMN), which is obtained by subtracting event-related potentials (ERPs) evoked by the deviant from ERPs evoked by the standard. There are three hypotheses to explain the vMMN. The sensory fatigue (or refractoriness) hypothesis considers that weakened neural activity caused by repetition results in decreased ERPs of the standard. The memory trace hypothesis proposes that vMMN results from increased responses to the deviant. The predictive coding hypothesis attributes the difference to enhanced responses for deviants and suppression for standards. However, when distinguishing between these effects, previous researchers did not consider the effect of low-level features on the vMMN. In this experiment, we used face sequences composed of different emotions (e.g., neutral and fearful face) and presented an oddball sequence, a reverse oddball sequence, and an equiprobable sequence to participants. The deviant of the oddball sequence was subtracted from the standard of the oddball sequence, the reverse oddball sequence, and the same type of stimulus of the equiprobable sequence to get oddball-vMMN (vMMN1), reverse oddball-vMMN (vMMN2), and equiprobable-vMMN (vMMN3), respectively. The results showed no significant difference between vMMN2 and vMMN3 in 100–350 ms following stimulus onset, while the vMMN effect was significant, indicating that the probability of the standard did not affect vMMN, which supported the memory trace hypothesis. Additionally, the fearful-related vMMN were more negative than the neutral-related vMMN within the range of 100–150 ms, suggesting a negative bias. We analyzed the source location of different vMMNs. There was no significant difference in brain regions between different vMMNs. Time-frequency analysis showed that the deviant had stronger theta-band oscillatory than the standard (visual mismatch oscillatory responses, vMORs). However, there was no difference between vMORs2 and vMORs3, indicating that vMORs reflect an enhanced response to the deviant in terms of neural oscillation, supporting the memory trace hypothesis.