Miracle-dz/UniFAR-FTUs huggingface dataset:
Composition of Cash Flow Shocks, Firm Investment, and Cash Holdings

We model the savings and investment decisions of firms facing costly external financing and a mix of temporary and persistent shocks to their cash flows. We show that, while exposure to both types of shocks induces firms to save, the two types of shocks generate distinct and typically opposite effects on the dynamics of savings and investment. We develop several novel predictions about the effect of the mix of temporary and persistent shocks on the level of cash savings, the sensitivity of savings to cash flows and the sensitivity of investment to cash savings. Our empirical tests support these predictions and demonstrate the importance of accounting for the mix of persistent and temporary shocks to firm cash flows when explaining cross-sectional variation in corporate savings and investment.
Spatial statistical analysis of infrastructure systems in Calgary, Alberta

In this paper, the consumption of various infrastructure systems in Calgary, Alberta by residential, commercial, and industrial sectors is considered. Statistical models are developed to quantify the influences of built form factors, in addition to traditional factors of sociodemography. Analyses are performed by census community for electricity, transportation by mode of travel, and demolition permits by their size and frequency. The employment of a common methodology in a single geography allows for comparison across infrastructure systems and determination of common patterns. Assessing total consumption does not necessarily lead to a consistent interpretation. By differentiating electricity consumption by sector and transportation by mode, consistent analysis can be conducted that identifies the correct relationships. We find a trend toward increasing consumption of electricity use moving out from the center of the city, but also an increasing reliance on the private automobile.
Roles and Motivations of Planning Professionals Who Promote Public Participation in Urban Planning Practice: Two Case Studies from Beijing, China

Public participation in urban planning is a contested issue in China. In this article, we look at the endogenous mechanism of institutional change, by analyzing the roles and motivations of “third-party” planning professionals in two contrasting cases: a government-led and a citizen-led participatory practice. Findings show that planners were advocates of citizen participation in heritage preservation in both cases and acted as “mediators” in the first and “activists” in the second, yet remained within the mainstream planning structure. Their motivation to serve the rights of the citizens was clear, but subordinate to the drive to conform to the professional norms of authenticity in preservation in both cases. In contrast to both the Global North where more agonistic approaches question inclusive planning and the Global South where insurgent planning finds space to maneuver, Chinese urban planning seems to proceed by taking small steps within narrow margins when it comes to citizen engagement.
A Welfare‐Based Analysis of International Monetary Policy Spillovers at the Zero Lower Bound

We study the welfare effects of international monetary policy spillovers at the zero lower bound, focusing on the effects of forward guidance in a large economy (“foreign”) on its smaller trading partner (“home”) in scenarios motivated by the global financial crisis. We find that foreign forward guidance has an overall prosper‐thy‐neighbor effect on the home economy as long as it increases foreign welfare. This finding holds under alternative assumptions about exchange rate pass‐through or the degree of international financial integration. However, foreign forward guidance may worsen the trade‐off between the stabilization objectives of home monetary policy.
The Eurasian steppe belt: Status quo, origin and evolutionary history

We present a comprehensive review of the characteristics and structure of the Eurasian steppe and of its evolutionary history in space and time. During the last decades, tremendous advances in research methods in earth and palaeontological sciences have greatly increased knowledge on palaeoclimates and palaeoenvironments of the Cenozoic era. We discuss well-known facts against the background of the recent progress made in these fields and others related to our topics, and address open questions. In Part I (Status quo), we deal with steppe classification systems, human impact and present state of the Eurasian steppe. Here, we concentrate on prehistoric times when the first human cultures emerged, and on the last 100 to 200 years when drastic changes occurred and in many regions steppe nearly completely disappeared. In Part II (Origin and evolutionary history of the Eurasian steppe) we attend to the origin and evolution of grasses and grassland in general, and to the evolution and climate/landscape history of the Eurasian steppe belt in particular. Uplift of the Himalayan-Tibet Plateau, changes in land-sea distribution and global climate trends have been invoked as driving forces behind Cenozoic paleoclimate changes, but there is little consensus which one is the most important driver. We finally identify gaps/challenges in our knowledge about the evolutionary history of the Eurasian steppe and discuss research directions, which might help to unravel the florogenetic and steppe habitat dynamics from the beginning of steppe formation to the present time.
Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate or the expression of a marker gene. Information-rich assays, such as gene-expression profiling, are generally not amenable to efficient profiling of a given perturbation across multiple cellular contexts. Here, we developed MIX-Seq, a method for multiplexed transcriptional profiling of post-perturbation responses across a mixture of samples with single-cell resolution, using SNP-based computational demultiplexing of single-cell RNA-sequencing data. We show that MIX-Seq can be used to profile responses to chemical or genetic perturbations across pools of 100 or more cancer cell lines, and combine it with Cell Hashing to further multiplex additional experimental conditions, such as multiple post-treatment time points or drug doses. Analyzing the high-content readout of scRNA-seq reveals both shared and context-specific transcriptional response components that can identify drug mechanism of action and can be used to predict long-term cell viability from short-term transcriptional responses to treatment.
Comparative study of pathological lesions of liver in autopsy cases

Background: Liver is a site for plethora of diseases among which many become symptomatic while others usually either go undiagnosed or are concealed by other prominent diseases. As said about liver to be the custodian of milieu interior most of the silent liver diseases are diagnosed only on autopsy examination. Aims and objectives was to study various pathological lesions of liver in medicolegal and clinical autopsy cases and to corelate liver diseases with age and sex. Retrospective cross-sectional observational study of 649 medicolegal and clinical autopsies conducted within 2 years of duration (January 2017 to December 2018). Methods: Out of all 649 autopsies conducted in our hospital all liver specimens along with other organs viscera were collected and formalin fixed. After gross examination sections from the liver were submitted for tissue processing and then stained with haematoxylin and eosin stain. Results: The most common pathology found in our study was fatty change (11.1%) followed by venous congestion (4.3%), hepatitis (3.5%), cirrhosis (2.2%), tuberculosis/ granulomatous hepatitis (0.6%), chronic hepatitis (0.3%), malignancy (1%), miscellaneous (2%) and normal (72.4%). Maximum cases were in 21-30 years of age group with male preponderance. Conclusions: Autopsy examination of liver is an effective tool to identify silent liver diseases. Use of autopsy findings along with other investigative techniques.
Design and Comparative Techno-Economic Analysis of Two Solar Polygeneration Systems Applied for Electricity, Cooling and Fresh Water Production

Two solar polygeneration systems were investigated for electricity, cooling and fresh water production. In the first scenario (LFPS), the linear Fresnel (LF) solar field was used as thermal source of the Organic Rankine Cycle (ORC), absorption chiller (ACH) and multi-effect desalination (MED) unit. In the second scenario (PVPS), photovoltaic (PV) panels were considered as the electricity source to supply the electricity load that is required for lighting, electrical devices, compression chiller (CCH) and reverse osmosis (RO) units. A techno-economic comparison was made between two scenarios based on the land use factor (F), capacity utilization factor (CUF), payback period, levelized cost of electricity (LCE), levelized cost of cooling energy (LCC) and levelized cost of water (LCW). The calculations were conducted for four different locations in order to determine the effect of solar radiation level on the LCE, LCC and LCW of systems in both scenarios. The results showed that the LCE and LCW of PVPS is lower than that of LFPS and the LCC of LFPS is lower than that of PVPS. Also, the payback period of LFPS and PVPS systems are obtained as 13.97 years and 13.54 years, respectively, if no incentive is considered for the electricity sale.
Real-world outcomes in first-line treatment of metastatic castration-resistant prostate cancer (mCRPC): The prostate cancer registry.

212Background: The Prostate Cancer Registry is the first prospective, international observational study in mCRPC documenting characteristics and management in routine clinical practice, independent of treatment used. The study began in June 2013 enrolling > 3000 mCRPC patients (pts) followed for ≤ 3 years. Methods: Source-verified data were collected from men with documented mCRPC initiating a new mCRPC treatment or in surveillance. A history of disease progression despite surgical or chemical ADT was confirmed in all pts. This interim analysis reports baseline characteristics, treatments and outcomes in pts with no prior mCRPC treatment. To evaluate comparative effectiveness between treatments, propensity scoring (PS) methods were used to reduce effects of confounding. Results: Of 1906 evaluable pts with ≥ 12-month follow-up, the most commonly initiated first-line mCPRC treatments (n ≥ 50) were abiraterone acetate + prednisone (AA, n = 472), enzalutamide (ENZ, n = 98) or docetaxel (DOC, n = 382). Baselin.
PENGARUH GAYA KEPEMIPINAN, BUDAYA ORGANISASI DAN STRES KERJA TERHADAP KINERJA KARYAWAN (Studi Kausal di Layanan Social Media TelkomCare Telkom Indonesia Jakarta)

This study aims to obtain empirical data, facts, and valid and correct information, and can be trusted, about Leadership Style, Organizational Culture and Work Stress on Employee Performance. Using a quantitative research approach and the survey method. To prove the influence of the variables of Leadership Style, Organizational Culture and Job Stress on Performance in this study, data analysis techniques were carried out with Path Analysis. Based on the results of the research analysis: There is a positive and significant direct effect of the Leadership Style variable on Job Stress. There is a positive and significant direct effect of the Organizational Culture variable on Job Stress. There is a positive and significant direct effect of the Leadership Style variable on Performance. There is a positive and significant direct effect of the Organizational Culture variable on the Performance variable. There is a positive and significant direct effect of the Job Stress variable on the Performance variable. Keywords: Leadership Style, Organizational Culture, Job Stress and Performance
Learning Culture: First-Year Student Transition, Institutional Culture, and the Bubble of Trial Adulthood

The transition from high school to college involves a number of social, cultural, and psychological forces. Research rarely considers the ways in which institutional culture is transmitted to students during students’ first year of college. This qualitative research study fills this gap in the literature by reporting the findings of 62 one-on-one interviews that considered how students made sense of their transition to higher education. Using institutional culture as a framework, data was analyzed through interpretative thematic analysis strategies. Data analysis revealed several key themes that depict the techniques students employed during their first year that enabled their recreation and performance of the peer norms of the university’s culture. Through immersion, trial and error, and mimicking peer behavior, participants navigated what they called the bubble of trial adulthood. This paper draws several implications for practice and conclusions from the data.
Efficacy of adjuvant trastuzumab (T) compared with no T for patients (pts) with HER2-positive breast cancer and tumors ≤ 2cm: A meta-analysis of the randomized trastuzumab trials.

508 Background: Adjuvant T plus chemotherapy improves disease-free survival (DFS) and overall survival (OS) vs. chemotherapy alone for pts with early stage HER2-positive breast cancer. We conducted a meta-analysis to estimate DFS and OS for pts with small tumors (≤2cm) in the T arms from 5 of the 6 randomized adjuvant trastuzumab trials. Pts with tumors ≤2cm, with 0 or 1 positive lymph nodes, and hormone receptor (HR) positive disease had a 5-year DFS of 91% and a 5-year OS of 97% (O’Sullivan, SABCS 2013; abstract:1327). We now plan to conduct an additional meta-analysis to assess the efficacy of T compared with no T for pts with small tumors (≤2cm). Methods: Six randomized controlled trials (RCT) were identified by a Medline search from 2004-2013. Trial groups from 5 phase III RCTs provided data (HERA, NCCTG N9831, NSABP B31, PACS 04, and FinHER). In total, 11,200 pts were randomized in these 5 trials;4,220 of whom had ≤2cm tumors, and known number of positive axillary lymph nodes and HR status(2,588 rand.
CTXT: hacia un modelo de negocio posible para el periodismo digital independiente

El presente trabajo tiene por objetivo profundizar en el conocimiento de CTXT, un semanario digital independiente de informacion general fundado en enero de 2015 por periodistas procedentes de diarios espanoles de referencia y que en apenas cuatro anos ha conseguido hacerse un hueco en el ecosistema mediatico actual. A partir de una investigacion etnografica en curso sobre este nuevo cibermedio, nos centramos aqui en el analisis de su modelo de negocio, un aspecto central en el nacimiento y desarrollo de una pequena empresa como CTXT, que emergio como una cuestion clave durante nuestro trabajo de campo. En un contexto de gran dificultad para levantar una nueva empresa periodistica independiente, este modelo ha sido posible gracias a un continuo esfuerzo de busqueda, experimentacion y diversificacion de las fuentes de ingresos y gracias a la pasion por el periodismo y al trabajo poco remunerado o gratuito de periodistas y otros profesionales muy cualificados. El esfuerzo del equipo se ha orientado a hacer productivo su importante capital simbolico (para construir la marca de un periodismo cualificado, independiente y alternativo al mainstream) y su capital social (sus redes con personas y con otros medios afines) para, pese a su reducido capital financiero, hacerse relevante en la esfera mediatica. El periodismo que propone CTXT, atento a ser reflexivo, critico y de calidad, ha sabido encontrar su nicho de audiencia y hacer oir su voz en la escena mediatica.
Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence

Telomeres adopt a lariat conformation and hence, engage in long and short distance intra-chromosome interactions. Budding yeast telomeres were proposed to fold back into subtelomeric regions, but a robust assay to quantitatively characterize this structure has been lacking. Therefore, it is not well understood how the interactions between telomeres and non-telomeric regions are established and regulated. We employ a telomeric chromosome conformation capture (Telo-3C) approach to directly analyze telomere folding and its maintenance in S. cerevisiae. We identify the histone modifiers Sir2, Sin3 and Set2 as critical regulators for telomere folding, which suggests that a distinct telomeric chromatin environment is a major requirement for the folding of yeast telomeres. We demonstrate that telomeres are not folded when cells enter replicative senescence, which occurs independently of short telomere length. Indeed, Sir2, Sin3 and Set2 protein levels are decreased during senescence and their absence may thereby prevent telomere folding. Additionally, we show that the homologous recombination machinery, including the Rad51 and Rad52 proteins, as well as the checkpoint component Rad53 are essential for establishing the telomere fold-back structure. This study outlines a method to interrogate telomere-subtelomere interactions at a single unmodified yeast telomere. Using this method, we provide insights into how the spatial arrangement of the chromosome end structure is established and demonstrate that telomere folding is compromised throughout replicative senescence. Author summary Telomeres are the protective caps of chromosome ends and prevent the activation of a local DNA damage response. In many organisms, telomeres engage in a loop-like structure which may provide an additional layer of end protection. As we still lack insight into the regulation of the folded telomere structure, we used budding yeast to establish a method to measure telomere folding and then study the genetic requirements for its establishment. We found that cells require the homologous recombination machinery as well as components of the DNA damage checkpoint to successfully establish a folded telomere. Through the deletion of telomerase in budding yeast, we investigated how telomere folding was regulated during replicative senescence, a process that occurs in the majority of telomerase negative human cells. During senescence, telomeres gradually shorten and erode until cells stop dividing which is a potent tumor suppressor and prevents unscheduled growth of potential cancer cells. We found, that the folded telomere structure is compromised as part of the cellular senescence response, but not due to telomere shortening per se. We think, that an altered telomeric chromatin environment during senescence is important to maintain an open state – which may be important for signaling or for repair.
Long-term variations of the sea level on the western coast of the Antarctic Peninsula

The aim of the study is to analyze seasonal and interannual changes in sea level on the western coast of the Antarctic Peninsula. Objects of study are seasonal and interannual variability of sea level, air temperature, pressure at sea level, precipitation in the period 1960–2018 at the Faraday/Akademik Vernadsky station, which was considered as representative site for the Antarctic Peninsula. Statistical methods of study were used, including estimates of linear trends of time series using the nonparametric Sen’s estimator of slope. The Mann-Kendall test was used to assess the significance of the slope of the trend. Time variability analysis was performed using wavelet analysis. Using the MATrix LABoratory (MATLAB) software package, squared of wavelet coefficients were calculated depending on the scale and shift or scalograms that characterize the local energy spectrum, and scalegrams calculated by averaging the scalograms by time shifts. The Morlet wavelet transformations were used. The results of the calculations showed that the trend of sea level at the Faraday/ Akademik Vernadsky station in the period 1960—2018, according to observations and correction on glacial isostatic adjustment of the crust is in the range from 3.05 to 3.45 mm/year, which is significantly higher than the global trend of 2.1 mm/year. Sea level scalograms allow estimating time-averaged periods and amplitudes of the coefficients for each season. In the austral winter and spring characteristic periods were 4—6 years, whereas the summer and autumn periods are characterized by 6–8 years, as well as by the highest amplitudes of the coefficients. All seasons are characterized by the appearance of a weakly pronounced period of about 4 years. The presence of peaks in the scalegrams at 6–8 and 3–4 years confirms the relationship of atmospheric and oceanic processes in West Antarctica to the natural variations of the ocean-atmosphere system, such as the Southern Annular Mode and El Nino-Southern Oscillation, which varies with typical 3–4 and 6–8 year periods. It was concluded that, unlike air temperature, the sea level trend is relatively weakly depends on the season, with the exception of autumn, when sea level trend is three times smaller than the average value. At the same time, the air temperature trend is the largest in the austral winter and the lowest in the summer.
Blowups with canonical singularities.

Using only elementary toric methods and facts about quotient singularities and lattice simplices, we show that for any fixed dimension $d$ there is a constant $\ell_d$ such that if a weighted blowup of $\mathbb{A}^d$ has only canonical singularities then the smallest of the weights cannot exceed $\ell_d$. This is a special case of a conjecture of Birkar. Using the recent classification of $4$-dimensional empty simplices by Iglesias-Vali\~no and Santos, we show that for blowups of $\mathbb{A}^4$ with terminal singularities the smallest weight is at most $32$, and at most $6$ in all but finitely many cases.
A mediation model for relational aggression, victimization, attachment, and depressive symptoms in Guam: A gender-informed approach

The present study examined the association between relational aggression and depressive symptoms, and the serial mediation of relational victimization and attachment insecurity in this association from a gender-informed approach. Participants consisted of 35 students (77% female; age: 18–25) for the pilot qualitative study and 206 students (68% female; age: 18–25) for the main quantitative study. Both sets of participants were recruited at the same public university in Guam. The qualitative data were transcribed verbatim and coded by three trained researchers (interrater agreement = 90%). From the qualitative data, several themes, such as relational aggression and victimization, physical aggression and victimization, negative affect and emotion, and culture emerged. All participants reported the use of relational aggression and showing negative emotions in a close relationship. Gender differences in the content of the themes were also found, such that relational aggression and victimization seemed to be more emotionally stressful for women than men. In line with these qualitative findings, the quantitative data showed that relational aggression was associated with depressive symptoms, and this association was mediated by relational victimization and attachment anxiety (not avoidance) only for women, while the contributions of physical aggression and victimization were controlled for. No direct and indirect links for physical aggression was evidenced. These findings are discussed from clinical, developmental and cultural perspectives.