Miracle-dz/UniFAR-FTUs huggingface dataset:
Taxa of family Fabaceae: a potential of local medicinal values in Vindhya region Uttar Pradesh, India.

The Vindhya region of Uttar Pradesh includes Mirzapur and Sonbhadra districts, which is mostly covered with forest. During exploration of this region we collected 51 species of 35 taxa is belonging to the family Fabaceae. Among these species an account of 23 ethno-medicinal information which is traditional used by tribes like Gond, Kols, Mushar, Baiga & Nutts from this region and 19 species are used as medicines in the welfare of the people. The ethno-medicinal uses, disease, localities and field numbers has been provided in this paper.
Walk Locomotion Kinematic Changes in a Model of Penetrating Hippocampal Injury in Male/Female Mice and Rats

Traumatic brain injury has been the leading cause of mortality and morbidity in human beings. One of the most susceptible structures to this damage is the hippocampus due to cellular and synaptic loss and impaired hippocampal connectivity to the brain, brain stem, and spinal cord. Thus, hippocampal damage in rodents using a stereotaxic device could be an adequate method to study a precise lesion from CA1 to the dentate gyrus structures. We studied male and female rats and mice, analyzing hindlimb locomotion kinematics changes to compare the locomotion kinematics using the same methodology in rodents. We measure (1) the vertical hindlimb metatarsus, ankle, and knee joint vertical displacements (VD) and (2) the factor of dissimilarity (DF). The VD in intact rats in metatarsus, ankle, and knee joints differs from that in intact mice in similar joints. In rats, the vertical displacement through the step cycle changed in the left and right metatarsus, ankle, and knee joints compared to the intact group versus the lesioned group. More subtle changes were also observed in mice. DF demonstrates contrasting results when studying locomotion kinematics of mice or rats and sex-dependent differences. Thus, a precise lesion in a rodent’s hippocampal structure discloses some hindlimb locomotion changes related to species and sex. Thus, we only have a qualitative comparison between murine species. In order to make a comparison with other species, we should standardize the model.
Attitudes of the Host Population towards Syrian Refugees: A New Theoretical Perspective

This study delves into the nuanced attitudes of the host community in Izmir, Turkey, towards Syrian refugees, employing a robust threat and benefit theoretical model. It scrutinizes the multifaceted factors contributing to perceived threats and benefits, elucidates the reasons behind the variation in these attitudes, identifies the individuals responsible for holding these perspectives, pinpoints the specific contexts in which they manifest, examines the temporal dimension of these attitudes, and dissects the profound impact they have on mutual adaptation processes and the formulation of migration policies. A diverse group of 34 participants from the host community actively engaged in semi-structured interviews, comprising 16 females and 18 males across an age spectrum spanning 19 to 64 years. Thematic analysis methodically uncovered that economic and demographic considerations prominently constitute the bedrock of perceived threats, while conversely, the study illuminated financial contributions as pivotal benefits. The in-depth understanding garnered from this study holds significant promise for fostering enduring mutual adaptation between the host and refugee communities, thereby cultivating a more harmonious coexistence. Additionally, this nuanced insight informs the strategic development of immigration policies, ensuring they align with the evolving dynamics of this complex relationship.
Altimetric Observations and Model Simulations of Coastal Kelvin Waves in the Bay of Bengal

Wavelet analyses of sea surface height (SSH) obtained from Simple Ocean Data Assimilation (SODA) reanalysis, satellite altimetry derived SSH anomalies during 1993–2006, and HYbrid Coordinate Ocean Model (HYCOM) simulations of SSH during 2003–2006 in the tropical Indian Ocean reveal dominant annual Kelvin waves in the equatorial wave guide and dominant semiannual Kelvin waves off Sumatra coast and along the coastal Bay of Bengal. This study reveals variability in the propagation of upwelling Kelvin wave during winter and summer monsoons and downwelling Kelvin wave during monsoon transitions. Further, the winter transition downwelling Kelvin wave largely affects the coastal circulation of India.
Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration

Parkinson’s disease (PD) is the most common movement disorder, characterized by the progressive loss of dopaminergic neurons from the nigrostriatal system. Currently, there is no treatment that retards disease progression or reverses damage prior to the time of clinical diagnosis. Mesenchymal stem cells (MSCs) are one of the most extensively studied cell sources for regenerative medicine applications, particularly due to the release of soluble factors and vesicles, known as secretome. The main goal of this work was to address the therapeutic potential of the secretome collected from bone-marrow-derived MSCs (BM-MSCs) using different models of the disease. Firstly, we took advantage of an optimized human midbrain-specific organoid system to model PD in vitro using a neurotoxin-induced model through 6-hydroxydopamine (6-OHDA) exposure. In vivo, we evaluated the effects of BM-MSC secretome comparing two different routes of secretome administration: intracerebral injections (a two-site single administration) against multiple systemic administration. The secretome of BM-MSCs was able to protect from dopaminergic neuronal loss, these effects being more evident in vivo. The BM-MSC secretome led to motor function recovery and dopaminergic loss protection; however, multiple systemic administrations resulted in larger therapeutic effects, making this result extremely relevant for potential future clinical applications.
Precipitation Phase Discrimination in Sweden

Estimation of snow storage in hydrological, regional and global climate models depends on correctly identified precipitation phases, proper snow/rain separation is especially crucial for canopy snow models. Precipitation phase is seldom reported from increasingly automated stations, so most models use one or two static air temperatures to separate rain from snow. However, some models use more elaborated algorithms for phase determination. The aim with this study is to verify if the phase accuracy can be improved by using such schemes. Forty-five years of threehour man-made precipitation phase observations for nineteen Swedish stations were used to mpare different phase separatio r temperature was found as a better precipitation phase indicator than dew point temperature. If an assumed 0˚C air temperature threshold, a default value in some recent models, is rep 1.0˚C the misclassified precipitation is reduced by almost half and can be further reduced with ividual station thresholds. Schemes using two temperature thresh with a linear increase in percent rain from 0˚C to 2˚C, or from -1˚C to 3˚C performed better than tic thresholds at all stations. When the, 16% total, mixed precipitation is included as half rain d half snow a linea dependent snow probability curve using all stations produced lower misclassified precipitation ors in all but 5 cases when lower miscl increasing schemes.
Copulation of Ixodes ricinus males and females on the host and its potential impact on pathogen transmission.

INTRODUCTION AND OBJECTIVE The common tick Ixodes ricinus is one of Europe's most important vectors of tick-borne diseases. The increased risk of attacks by this tick suggests the need for identification of factors contributing to the transmission of tick-borne pathogens, and the routes of pathogen circulation in nature. MATERIAL AND METHODS Polymerase chain reaction was used to investigate the prevalence of four pathogens, i.e. Borrelia burgdorferi s.l. (Bb), Anaplasma phagocytophilum (Ap), Babesia spp. (Bs), and Bartonella spp. (Ba) in I. ricinus females and males mating on dogs in south-central Poland. RESULTS The study revealed the presence of three pathogens: Bb, Ap, and Bs in 9.4%, 5.4%, and 5.4% of all I. ricinus adults in copula, respectively. Co-infection with two pathogens was detected in one tick specimen. Borrelia burgdorferi spirochetes were isolated in two females and two males in copula, but the sexual transfer of the spirochetes between these specimens could not be clearly confirmed. CONCLUSIONS By increasing the feeding dynamics in females, the copulation of I. ricinus males with females attached to the host's skin may stimulate pathogen replication in tick tissues and migration from the gut to the salivary glands. Further investigations of the I. ricinus copulation on the host on female feeding and pathogen transmission may contribute to the elucidation of the eco-epidemiology of tick-borne diseases transmitted by this tick species.
Determinant Factor of Sustainable Tourism Studies in the Tourism Sector in South Kalimantan with Innovation as a Mediating Variable

This research is motivated by the importance of sustainable tourism aspects in achieving the Sustainable Development Goals (SDGs) which countries around the world have adopted this concept. This study is focused on Tourism Objects in South Kalimantan Province as a tourism destination in Indonesia. The method used in this research is an empirical study method with a quantitative approach. The technique used is a proportional sample with the help of the SEM (Structural Equation Modeling) program which is operated through the SmartPLS program. This study uses the formula Hair, et.al., (1995) with the provisions of 5 x 43 item parameters times the number of research questionnaires, namely 215 research samples. Methods of data collection using a questionnaire. The research hypothesis was tested using the Partial Least Square (PLS) based Structural Equation Model (SEM) approach. Society participation, Tourism Social Entrepreneurship, Destination Governance and Innovation have a significant effect on Sustainable Tourism. Furthermore, Society participation, Tourism Social Entrepreneurship, Destination Governance have a significant effect on Innovation. And Innovation mediates the relationship between Society participation, Tourism Social Entrepreneurship, and Destination Governance towards Sustainable Tourism. This study is expected to provide a better understanding of how innovation can be an important factor in achieving sustainable tourism in South Kalimantan.
Effect of methanol root extract of Pausinystalia yohimbe on epididymal sperm cells of Wistar albino rats

The epididymis is essential for spermatozoa maturation, including the acquisition of progressive motility and fertilizing ability. Without a safe dose regimen treating several related reproductive disorders, the root of P. yohimbe remains one of the many herbs commonly used by traditional herbal medicine practitioners in achieving such roles. The purpose of this study was to examine the effect of herbal extract on sperm parameters and histoarchitexture of epididymal sperm cells in rats. Twenty-five Wistar rats were randomly assigned to one of four treatment groups and one control group. For 28 days, the control group received only 10 mL/kg distilled water, while the treatment groups received 25, 50, 100, and 200 mg/kg b.w of P. yohimbe methanol root extract via oral cannula. On day 29, all animals were anesthetized, and their caudal epididymis was isolated and histologically processed. P. yohimbe root extract increased sperm count and motility, with normal histological indices of the epididymises examined relaying immune-protected sperm cells in normal spermatogenetic sequential maturation and viability, without lesion or architectural degeneration, and was comparable to, but not different from, the control. The current study supports the safety profile of P. yohimbe herbal preparation in doses administered to male Wistar rats, and that it could be used to justify human circumstances, potentially improving human health. However, future research on this plant may attempt to look at higher doses under similar conditions, providing a foundation for further screening and research.
Pumping optimization in saltwater‐intruded coastal aquifers

This paper investigates the hydraulic issues of pumping well optimization in saltwater‐intruded coastal aquifers. The well field includes freshwater outflow, pumping wells, and a recharge canal. The objective is to maximize the total pumping rate subject to the constraint of no intrusion of the saltwater front into the wells. Analytical solutions are presented for one‐well, two‐well, and one‐well‐with‐recharge‐canal problems. For problems involving multiple pumping wells, a structured messy genetic algorithm is used to search for the optimal solution.
Does obesity Kuznets curve exist in developing economies? Evidence from 38 African countries based on heterogeneous panel data analysis on income-level classification

Introduction The global pandemic disease known as the obesity epidemic has spread throughout the planet. Particularly, Africa is facing a growing problem of obesity, and the trend is rising. This is a result of a ticking time bomb. Given the claim that multiple socio-economic factors significantly affect the diversity in obesity rates between nations, economic development can be seen as a key contributor to this variation. Methods Relying on the aforementioned avowal, this extant research examines the relationship between obesity and economic growth using urbanization, trade openness, and unemployment as intermittent variables within the Obesity Kuznets Curve (OKC) framework. Using panel data from 1990 to 2020, a panel of 38 African countries subdivided into income levels (Low income, Lower-middle income, and Upper-middle income) were analyzed. With the presence of residual cross-sectional reliance and slope heterogeneity, the Augmented Mean Group (AMG) econometric approach is employed. Results Key outcomes from the mentioned estimation method unveiled that economic growth positively impacts obesity among all the study panels. Variably, unemployment was evidenced to have a palpable positive impact on obesity concerning Low-income economies whereas on the side of the Lower-middle income panel together with Upper-middle income economies and the aggregated panel, a significant negative relationship is observed with obesity. Further, urbanization enhanced obesity in the Low-income panel and the aggregated panel of African nations, whereas an adverse effect is identified in both the Lower-middle and Upper-middle economies in Africa. Moreover, except for Low-income African economies, all the other panels of African nations in terms of income levels were noted to have a significant negative effect on obesity from trade openness. Discussion Finally, the long-run coefficients indicated that the OKC is valid among all panels of African countries. The study thus preferably suggests in African economies that addressing the inverted U-shape relationship between obesity and economic growth requires a multifaceted approach that considers the evolving dynamics of both factors. Policy makers should, therefore, aim to balance promoting economic growth and safeguarding public health through targeted interventions and long-term strategies.
Water quality effects of crop residue removal for cellulosic ethanol production

Crop residues have been identified as a prime feedstock for large-scale cellulosic ethanol production. Therefore, understanding the impacts of widespread residue harvest on soil and environment is essential to establish soil-specific residue harvest rates. We assessed the effects of variable levels of corn residue removal on runoff and soil erosion on a regional scale across three locations (Colby, Hugoton, and Ottawa) in Kansas. Five residue treatments that consisted of removing 0, 25, 50, 75, and 100% of corn residue after harvest were studied for losses of runoff, sediment, soil organic carbon (SOC), total N and P, NO3-N, NH4N, and PO4-P. Simulated rainfall at a rate of 76.2 mm/h in Colby and Hugoton, and 91.4 mm/h in Ottawa was applied for 30 min. Results of this regional study showed that runoff volume, SOC, and total N and P concentrations increased with increase in residue removal at all locations. In contrast, NO3-N, NH4-N, and PO4-P concentrations in runoff increased with decrease in residue removal rate, most likely due to nutrient leaching from residues. Our results suggest that high rates of residue removal for cellulosic ethanol production will increase sediment, SOC, and total nutrient loss in runoff, potentially resulting in soil and environmental degradation.
Sweet Orange Juice Processing By-Product Extracts: A Caries Management Alternative to Chlorhexidine

Dental caries is one of the most prevalent chronic diseases globally in both children and adults. This study investigated the potential of industrial sweet orange waste extracts (ISOWE) as a substitute for chlorhexidine (CHX) in managing dental caries. First, the cytotoxicity of ISOWE (40, 80, 120 mg/mL) and CHX (0.1 and 0.2%) on buccal epithelial cells was determined. ISOWE exhibited no overall toxicity, whereas CHX strongly affected cell viability. The combination of ISOWE and CHX significantly enhanced cell proliferation compared to CHX alone. Next, the antimicrobial efficacy of ISOWE, CHX, and their combination was assessed against a 7-day complex biofilm model inoculated with oral samples from human volunteers. CHX exhibited indiscriminate antimicrobial action, affecting both pathogenic and health-associated oral microorganisms. ISOWE demonstrated lower antimicrobial efficacy than CHX but showed enhanced efficacy against pathogenic species while preserving the oral microbiome’s balance. When applied to a cariogenic biofilm, the combined treatment of ISOWE with 0.1% CHX showed similar efficacy to 0.2% CHX treatment alone. Overall, the findings suggest that ISOWE is a promising natural anti-cariogenic agent with lower toxicity and enhanced selectivity for pathogenic species compared to CHX.
Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation

Cellular senescence is closely linked to endothelial dysfunction, a key factor in age-related vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known as SASP, leading to chronic inflammation (inflammaging) and vascular impairments. Albeit in a state of permanent growth arrest, senescent cells paradoxically display a high metabolic activity. The relationship between metabolism and inflammation is complex and varies across cell types and senescence inductions. While some cell types shift towards glycolysis during senescence, others favor oxidative phosphorylation (OXPHOS). Despite the high availability of oxygen, quiescent endothelial cells (ECs) tend to rely on glycolysis for their bioenergetic needs. However, there are limited data on the metabolic behavior of senescent ECs. Here, we characterized the metabolic profiles of young and senescent human umbilical vein endothelial cells (HUVECs) to establish a possible link between the metabolic status and the proinflammatory phenotype of senescent ECs. Senescent ECs internalize a smaller amount of glucose, have a lower glycolytic rate, and produce/release less lactate than younger cells. On the other hand, an increased fatty acid oxidation activity was observed in senescent HUVECs, together with a greater intracellular content of ATP. Interestingly, blockade of glycolysis with 2-deoxy-D-glucose in young cells resulted in enhanced production of proinflammatory cytokines, while the inhibition of carnitine palmitoyltransferase 1 (CPT1), a key rate-limiting enzyme of fatty acid oxidation, ameliorated the SASP in senescent ECs. In summary, metabolic changes in senescent ECs are complex, and this research seeks to uncover potential strategies for modulating these metabolic pathways to influence the SASP.
The Relationship of Knowledge, Parental Support and Self-Acceptance with the Level of Anxiety of Young Women in Facing Puberty at Junior High School 7 Jambi City in 2022

Introduction: Puberty is a phase of physical and psychological changes. Changes experience by adolescent can cause anxiety. Teenages girl are aware of their development that can cause anxiety, because of that, they need sufficient knowledge, support from their parents and a good concept of self-acceptance, so they are can be ready for puberty. Obective: The purpose of this study was to determine the relationship between knowledge, parents support, self-acceptance and anxiety levels in JHS 7 Jambi City. Method: The study was conducted using a cross-sectional design with a sample size of 161 respondents. Statistical test using chi square test. Result and Discussion: Correlation between knowledge and anxiety levels was obtained (p-value <.001), correlation between parents support and anxiety levels was obtained (p-value <.020), correlation between self-acceptance and anxiety levels was obtained (p-value <.001). Conclusion: Teenages girl have less knowledge that is as much 123 respondent (76.4%), teenages girl have negative parents suport that is as much 118 respondent (73.3%), teenages girl have low self-acceptance that is as much 125 respondent (77.6%). There was a significant correlation between knowledge, parents support and self-acceptance with anxiety levels
Tailoring follow-up endoscopy in patients with severe oesophagitis

Objective We aimed to investigate the clinical utility of follow-up oesophagogastroduodenoscopy (OGD2) in patients with severe oesophagitis (Los Angeles grades C or D) through evaluating the yield of Barrett’s oesophagus (BO), cancer, dysplasia and strictures. Second, we aimed to determine if the Clinical Frailty Scale (CFS) may be used to identify patients to undergo OGD2s. Design/method Patients in NHS Lothian with an index OGD (OGD1) diagnosis of severe oesophagitis between 1 January 2014 and 31 December 2015 were identified. Univariate analysis identified factors associated with grade. Patients were stratified by frailty and a diagnosis of stricture, cancer, dysplasia and BO. Results In total 964 patients were diagnosed with severe oesophagitis, 61.7% grade C and 38.3% grade D. The diagnostic yield of new pathology at OGD2 was 13.2% (n=51), new strictures (2.3%), dysplasia (0.5%), cancer (0.3%) and BO (10.1%). A total of 140 patients had clinical frailty (CFS score ≥5), 88.6% of which were deceased at review (median of 76 months). In total 16.4% of frail patients underwent OGD2s and five new pathologies were diagnosed, none of which were significantly associated with grade. Among non-frail patients at OGD2, BO was the only pathology more common (p=0.010) in patients with grade D. Rates of cancer, dysplasia and strictures did not vary significantly between grades. Conclusion Our data demonstrate that OGD2s in patients with severe oesophagitis may be tailored according to clinical frailty and only be offered to non-frail patients. In non-frail patients OGD2s have similar pick-up rates of sinister pathology in both grades of severe oesophagitis.