Miracle-dz/UniFAR-FTUs huggingface dataset:
Findings of grain coarsening temperature and grain growth of light weight steel used in automotive industry

Efforts have been made in this research and experimental work to observe the grain coarsening temperature (GCT) by keeping in view the formation of second phase particles. Four steels having different chemical compositions were heat treated at series of temperatures i-e 850°C, 925°C, 1000°C, 1100°C and 1175°C with holding time of 1 hour and 2 hours respectively. After heat treatment traditional method of grinding and polishing was applied to reveal the microstructure. Grain size distribution at each temperature was calculated by using matrox inspector and the result was plotted with origin data analysis software. It was found that presence of second phase particles can affect the grain growth phenomena in the experimental steels and also grain growth have consequences on grain coarsening temperature on the steel under investigation. Steel A (Nb-Al) showed the finest grain structure, Grain size of steel B (Nb) was slightly higher than that of steel A. In steel C (Al), AlN particles did not exist. The only particles present were of TiN. Hence, the mean grain size of steel C was higher than that of steel A and steel B.
A note on the Brown–Erdős–Sós conjecture in groups

Abstract We show that a dense subset of a sufficiently large group multiplication table contains either a large part of the addition table of the integers modulo some k, or the entire multiplication table of a certain large abelian group, as a subgrid. As a consequence, we show that triples systems coming from a finite group contain configurations with t triples spanning $ O(\sqrt t )$ vertices, which is the best possible up to the implied constant. We confirm that for all t we can find a collection of t triples spanning at most t + 3 vertices, resolving the Brown–Erdős–Sós conjecture in this context. The proof applies well-known arithmetic results including the multidimensional versions of Szemerédi’s theorem and the density Hales–Jewett theorem. This result was discovered simultaneously and independently by Nenadov, Sudakov and Tyomkyn [5], and a weaker result avoiding the arithmetic machinery was obtained independently by Wong [11].
Opening Closed Doors: Promoting IRB Transparency

Institutional Review Boards (IRBs) have substantial power and authority over research with human subjects, and in turn, their decisions have substantial implications for those subjects, investigators, and the public at large. However, there is little transparency about IRB processes and decisions. This article provides the first comprehensive taxonomy of what transparency means (or could mean) for IRBs — answering the questions “to whom, about what, and by what mechanisms? ” It also explains why the status quo of nontransparency is problematic, and presents arguments for greater transparency from the perspective of a variety of stakeholders. IRB transparency will make boards more accountable, improve the quality of their decision-making, facilitate consistency in board decisions, permit empirical study of IRBs, promote research efficiency, and advance trust in the research enterprise, among a variety of other benefits. Regulators should promote IRB transparency, IRBs themselves should commit to sharing as much information as they can within the confines of confidentiality requirements, and investigators can endeavor to take matters into their own hands by sharing IRB correspondence and IRB-approved protocols and consent materials.
Drug utilization study and prescribing patterns in psychiatry patients at a tertiary care hospital

The Drug utilization research pioneered work done by Arthur Engel, Sweden and Pieter Siderius, Holland has compared drug use between different countries and regions. The purpose was to find the rationality of drug therapy prescribed. The Drug utilization research (DUR) was defined by the WHO in 1977 as the marketing, distribution, prescription and use of drugs in a society, with special emphasis in resulting medical, social and economic consequences. Periodic evaluation of drug utilization pattern need to be done to enable suitable modifications in prescription of drugs to increase the therapeutic benefit and decrease the adverse effects. Irrational drug use is a widespread problem in many countries of the world.
Z-Score or S-Score Model is Better to Predict Financial Distress?: Test in State-Owned Enterprise Listed in IDX

this research investigated four stated-owned entreprise that have negative profit in 2016 and we investigated from 2012 to 2016 using Altman Z-Score and Springate SScore. The probability of bankcruptcy for all company , several step are conducted in this research, the first stage of the calculation of the financial ratios analysis of each company obtained from audit results published by the company from 2012 to 2016. In the second stage of calculation and analysis are included in the formula ZScore and SScore, In the third stage, we provide improvement advice to repair companies located in the gray area and distress category on Z-Score, and companies that fall into the high probability of bankruptcy category, if they have an S-Score below 0.862. Findings from this research show, there are two companies that experienced financial distress they are PT. Garuda Indonesia and PT. Krakatau Steel (<1.81) during 2012 to 2016, while PT. Aneka Tambang and PT. Indofarma must carefully maintain the performance of the company during the period of five years both companies have been included in the category of companies in the area of distress and gray area. Using S-Score, we found, there are three companies during 2012 until 2016, two companies into the high category bankruptcy that is PT. Garuda Indonesia and PT. Krakatau Steel . This indicates that both companies are likely to have substantial bankruptcy because they have an S-Score score below 0.862, for five consecutive years, while PT. Indofarma for four consecutive years from 2013 to 2016 has an S-Score value below 0.862 so it needs a comprehensive preventive measure to prevent the three companies from bankruptcy. The first suggestions is increasing company’s operational efficiency and the second is avoid using debt to financing company. Keywords— Z-Score; S-Score; Financial Distress
Antecedents of the adoption process: Insights from consumer packaged food goods

ABSTRACT The authors investigate the adoption process as a sequence of purchases and examine how marketing and consumer antecedents will influence the timing and depth of the process. The authors find (1) media advertising to be the most effective for trial likelihood, while in-store display to be the most effective for repeat purchase amount, (2) an nonlinear effect of price-promotion frequency through the adoption process, (3) a negative effect of assortment size on trial and repeat purchase likelihood, and (4) consumers’ variety-seeking and domain-specific innovativeness are relatively strong drivers of consumers’ trial likelihood. The findings can help provide guidance for marketing managers.
The role of using fair value on relevance and representation faithfulness of accounting information in accordance with the Common Conceptual Framework (FASB-IASB)

The global trend towards the use of fair value accounting is increasing, so the current study aimed to maximize the impact of fair value application on achieving relevance and representation faithfulness of accounting information in accordance with the common conceptual framework. To achieve the objective of this study, the researcher has determined in the theoretical framework the relationship of fair value with the characteristics of relevance and representation faithfulness of accounting information and the extent of achieving these characteristics, as well as conducting a field study by preparing a questionnaire distributed to a sample of academics (50) and auditors (50) with a total number of selected participants (100) of academics and auditors.
Endocrine adverse events related to immune-oncology agents: retrospective experience of a single institution

Background Immune-oncology agents (IOA) represent a turning point in the treatment of several solid tumors (ST). Although their toxicity compares favorably with other treatments, IOA associate immune-related adverse events (IR-AE), among which endocrine-related AE stand out. We retrospectively evaluated the occurrence of endocrine (E) IR-AE in a cohort of patients with several ST treated with IOA. In addition, we assessed the correlation between likelihood of survival and the occurrence of IR-AE. Methods We collected data on clinical and molecular characteristics, efficacy and AE of 260 patients with ST treated with IOA from 2013 to 2017. We excluded patients with prior conditions or treatments potentially affecting thyroid test results. Results Lung cancer was the most prevalent diagnosis (70.2%). EIR-AE appeared in 18.1% of patients (total of 38 EIR-AE) and consisted of hypothyroidism, hyperthyroidism, pituitary disorders and type 1 diabetes mellitus in 60.5%, 21.1%, 15.8% and 2.6% of patients, respectively. EIR-AE were associated mainly to nivolumab, nivolumab plus ipilimumab (41.2% and 26.5%) and appeared after a median of 4.2 cycles of treatment. Specific therapy was required in 65.8% patients. There were significant differences in both progression-free survival (PFS) and overall survival (OS) for patients who experienced EIR-AE compared to those who did not [PFS: 56.7 (NC–NC) vs. 27.7 (14.3–41.3) months, P=0.008; OS: NC (NC–NC) vs. 31.4 (20.7–42.1) months, P=0.001]. Conclusions The incidence of EIR-AE in our study is similar to other series. Patients who develop EIR-AE might have a better prognosis compared to those who do not experience them.
Novelty Search in representational space for sample efficient exploration

We present a new approach for efficient exploration which leverages a low-dimensional encoding of the environment learned with a combination of model-based and model-free objectives. Our approach uses intrinsic rewards that are based on the distance of nearest neighbors in the low dimensional representational space to gauge novelty. We then leverage these intrinsic rewards for sample-efficient exploration with planning routines in representational space for hard exploration tasks with sparse rewards. One key element of our approach is the use of information theoretic principles to shape our representations in a way so that our novelty reward goes beyond pixel similarity. We test our approach on a number of maze tasks, as well as a control problem and show that our exploration approach is more sample-efficient compared to strong baselines.
An Attempted Meta-Analysis of the Competency Restoration Research: Important Findings for Future Directions

ABSTRACT The competence to stand trial literature is vast, whereas the literature on competency restoration pales in comparison. Although such research has accumulated since the 1970s, no quantative synthesis of it has been conducted. Therefore, we considered over 1,000 publications and attempted to conduct the first meta-analysis of restoration data – using 51 independent competency restoration samples published over a 40-year period (1975–2013) with 12,781 defendants – ultimately concluding that the restoration literature does not currently lend itself to meta-analysis. Still, several important findings arose: (a) the base rate for competency restoration was 81% and the median length of stay (LOS) was 147 days overall and 175 days in single restoration group studies; (b) reported competency restoration procedures were overwhelmingly nonspecific across studies and not reported in more than half of them; (c) most studies used correlational designs, with only five studies comparing restored with unrestored defendants, and no useable existing pre- versus post-treatment studies; and (d) competence assessment instruments were used in fewer than one-third of studies, traditional psychological measures were used in fewer than one-quarter, with data presented in such a way as to eliminate the potential for quantitative aggregation and analyses. Overall, our findings are concerning because, despite 40 years of research, the available data essentially highlight the characteristics of those engaging in restoration and do not address variables associated with final restoration status. In addition, we continue to have no collective empirical understanding of the utility of competency or traditional assessment instruments in the restoration context. Finally, virtually no published data reflect specific intervention efforts that lead to competence restoration.
Emergency Management of the Leptospirosis Patient

Leptospirosis, a thin, motile spirochete with a hook-shaped end, is a zoonotic disease that affects wildlife, companion animals, and livestock. There are over 200 serovars of Leptospira, with some being saprophytic while others are pathogenic. Numerous reservoir hosts exist for Leptospira including raccoons, voles, skunks, dogs, pigs, cattle and rats, resulting in growing exposure to humans and to the environment.
Echocardiographic Evaluation of Cardiac Function in Hypothyroidism

1 Asst. Prof. Deptt. Of Medicine, S.C. B. Medical College, Cuttack 2 Associate Professor, Deptt. of Cardiology, S.C. B. Medical College, Cuttack 3 Ex PG Student, Deptt. of Medicine, S.C. B. Medical College, Cuttack 4 Asst. Prof. Deptt. of Medicine, S.C. B. Medical College, Cuttack Corresponding Author Dr Nirmal Kumar Mohanty Associate Professor, Deptt. of Cardiology, S.C. B. Medical College, Cuttack, India Abstract Hypothyroidism is one of the most common hormonal disorders being associated with increased cardiovascular morbidity and mortality. Early detection of diastolic dysfunction of left ventricle by echocardiography helps in timely therapeutic intervention with thyroid hormone supplementation and amelioration of symptoms. The main objective of the present study was aimed at the cardiovascular involvement in hypothyroid patients. The present study was carried out in 64 patients of hypothyroidism who attended to the hospital between September 2013 and September 2014 including both outpatients and inpatients. Echocardiography showed significant reduction in early diastolic filling (E) with augmented late diastolic filling (A) resulting in decreased E/A ratio suggesting significant diastolic dysfunction. Tissue Doppler imaging showed reduction in peak early diastolic velocity (E 1 ) and raised peak late velocity (A 1 ) with increased E/E 1 ration which is again suggestive of diastolic dysfunction. LV diastolic dysfunction was impaired in patients with hypothyroidism. Doppler echocardiography might be considered a reliable method for its assessment & further management.
PENGARUH PEMBERIAN JUS DAUN KELOR (Moringa Oleifera Lam) TERHADAP KADAR KOLESTEROL TOTAL ORANG DEWASA HIPERKOLESTEROLEMIA DI WILAYAH KERJA PUSKESMAS OEBOBO KOTA KUPANG

Hiperkolesterolemia merupakan peningkatan kadar kolesterol total dalam darah yang dapat menyebabkan terjadinya aterosklerosis. Daun kelor mengandung flavonoid dan memiliki efek hipokolesterol dapat menekan aktivitas enzim HMG-KoA reduktase sehingga dapat mengurangi biosintesis kolesterol total. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jus daun kelor terhadap kadar kolesterol total pada orang hiperkolesterolemia. Metode penelitian ini adalah Quasi experimental dengan rancangan control group pre test-post test. Subjek adalah orang dewasa usia 25-60 tahun yang memiliki kadar kolesterol total ≥200 mg/dl. Kelompok dibagi menjadi kelompok kontrol dan perlakuan dengan 10 subjek tiap kelompok. Kelompok perlakuan diberikan minuman jus daun kelor sebanyak 220ml per hari dan kelompok kontrol tidak diberikan, jus daun kelor dikonsumsi selama 3 hari. Kadar kolesterol total dianalisis dengan metode Cholesterol Oxidase Phenol Aminoantipyrin (CHOD-PAP). Uji normalitas data menggunakan Saphiro-wilk. Analisis statistik menggunakan uji wilcoxon rank test. Hasil dari penelitian ini minuman jus daun kelor sebanyak 220 ml per hari selama 3 hari tidak dapat menurunkan kadar kolesterol total secara signifikan yaitu dari 236,30 mg/dl menjadi 234,30 mg/dl (p=0.721). Sedangkan untuk kelompok kontrol terdapat kenaikan kolesterol total dari 226,20 menjadi 235,50 akan tetapi tidak bermakna secara statistik (p=0.114). Kesimpulan dari penelitian ini adalah pemberian minuman jus daun kelor sebanyak 220 ml per hari selama 3 hari tidak dapat menurunkan kadar kolesterol total secara signifikan
Penyerapan Tenaga Kerja Industri Provinsi Jawa Timur: Apakah Upah Minimum Masih Menjadi Faktor Penentu?

Model standar pasar tenaga kerja kompetitif memprediksi upah minimum sebagai faktor penentu penyerapan tenaga kerja. Dengan tren peningkatan upah minimum dan kinerja industri, penyerapan tenaga kerja masih mengalami fluktuasi. Penelitian ini bertujuan untuk menganalisis fakor – faktor yang mempengaruhi penyerapan tenaga kerja industri di provinsi Jawa Timur, Indonesia. Menggunakan data level Kabupaten / Kota, persamaan penyerapan tenaga kerja diestimasi dengan regresi data panel. Ditemukan bahwa penyerapan tenaga kerja industri dipengaruhi oleh PDRB (Produk Domestik Regional Bruto) industri; sedangkan upah minimum tidak menjadi indikator utama yang mempengaruhi penyerapan tenaga kerja seiring dengan implementasi kebijakan pengupahan di Indonesia yang mempertimbangkan PDB (Produk Domestik Bruto) dan inflasi. Implikasi dari temuan ini, pada wilayah dengan PDRB tinggi perlu fokus pada perbaikan kualitas tenaga kerja untuk meminimalisir shifting antara tenaga kerja dan modal; sedangkan wilayah dengan PDRB rendah perlu mempercepat pembangunan kawasan industri baru agar dapat menampung tren relokasi dan perpindahan tenaga kerja. Kata Kunci: Penyerapan Tenaga Kerja, Upah Minimum, PDRB Industri
The Impact of Violence on Iraqi Junior Doctors

While violence against healthcare workers is a global problem, health-care workers in war zones are even more prone to these violent acts with more serious consequences.1 After USA invasion in 2003, Iraqi academics (and doctors in particular) faced intolerable levels of violence and systematic targeting.2 They are exposed to assassination, kidnapping, threats, and forced displacement, especially in Baghdad where the security failure is at its most. The rate of violent events among Iraqi specialist doctors during 2004-2007 was estimated to be3.7%, and the rate of violent death at 1.6%. The Iraqi government has displayed no effectiveness in protecting Iraq’s brightest minds, and the killers are never being brought to justice.3 Repeated assaults is another trend of violence, in a 2008 survey that included four emergency department physicians, 80% of the physicians reported an assault by a patient or a family member, 38% of which involved a gun threat.4 On the other hand, the wages (Mean $5000-6000 annually) remain relatively low and discouraging considering the workload and increasing risks.5 The revival plan of the Iraqi health care system seems to be very slow and limping; lack of security, bad management, politicization of the Ministry of Health, and corruption, are all problems that decision makers have failed to solve.6–11
Preliminary Clinical Results of Topaz Microdebridement Procedure in Lateral Epicondylitis Patients

제35권 제3호 2017 155 Received: July 25, 2017 Revised: November 18, 2017 Accepted: November 19, 2017 Correspondence: Jae Chul Yoo Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea Tel: +82-2-3410-2114, Fax: +82-2-3410-2114, E-mail: shoulder.yoo@samsung.com *Sung Woo Hong and Yong Bok Park contributed equally to this study as first authors.
DRUG PRESCRIPTION PATTERN OF BREAST CANCER PATIENTS IN A TERTIARY CARE HOSPITAL IN WEST BENGAL: A CROSS-SECTIONAL AND QUESTIONNAIRE-BASED STUDY

Objective: Cancer is a disease of uncontrolled division of cells in any part of the body. Breast cancer most common in women accounts for 13% of the death worldwide. The objective of the present study was to evaluate the drug prescription pattern of breast carcinoma patients in a tertiary care hospital of West Bengal. Methods: This was a cross-sectional observational questionnaire-based study done for a period of 6 months at the Department of Pharmacology in Collaboration with the Department of Surgery and Department of Radiotherapy of a Tertiary Care Hospital at Kolkata, West Bengal, India. Female patients with breast cancer (originated from epithelial tissues) of different types and grade attending surgery outdoor patient department were taken as subjects for the study, after signing informed consent. Results: The present study evaluated 28 patients (n=28) diagnosed as breast cancer by the physicians of the department of surgery and radiotherapy. It was observed that breast cancer was mostly found in the middle age group. Breast carcinoma in postmenopausal women accounted to 75%. The most prevalent breast cancer was invasive ductal carcinoma, accounting to 75% of the study population. 5-Fluorouracil, epirubicin, doxorubicin, cyclophosphamide, docetaxel/paclitaxel, and carboplatin were mostly used as chemotherapeutic agent. Conclusion: Breast carcinoma being a prevalent type of cancer in females, the present study tried to evaluate the pattern of prescribing chemotherapeutic agents for breast cancer patients in a tertiary care hospital. Such study is essential to evaluate and refine the therapeutic regimen of the cancer patients to reduce their sufferings.
Relationship between Aortic Valve Sclerosis and the Severity of Coronary Artery Disease in Patients Undergoing Diagnostic Coronary Angiography

Submit Manuscript | http://medcraveonline.com known coronary atherosclerosis. After taking a detailed clinical history, with special attention to risk factor identification, all patients underwent complete transthoracic echocardiographic examination before they underwent coronary angiography on different days. Each of the tests was interpreted by two observers who were unaware of the results of the other tests. According to Tolstrup et al. [3] five grades (from grade 0 to grade 4) for AVS were classified. Grades 0 and 1 were classified as normal, while grades 2–4 were classified as AVS.
Trend following deep Q‐Learning strategy for stock trading

Computers and algorithms are widely used to help in stock market decision making. A few questions with regards to the profitability of algorithms for stock trading are can computers be trained to beat the markets? Can an algorithm take decisions for optimal profits? And so forth. In this research work, our objective is to answer some of these questions. We propose an algorithm using deep Q‐Reinforcement Learning techniques to make trading decisions. Trading in stock markets involves potential risk because the price is affected by various uncertain events ranging from political influences to economic constraints. Models that trade using predictions may not always be profitable mainly due to the influence of various unknown factors in predicting the future stock price. Trend Following is a trading idea in which, trading decisions, like buying and selling, are taken purely according to the observed market trend. A stock trend can be up, down, or sideways. Trend Following does not predict the stock price but follows the reversals in the trend direction. A trend reversal can be used to trigger a buy or a sell of a certain stock. In this research paper, we describe a deep Q‐Reinforcement Learning agent able to learn the Trend Following trading by getting rewarded for its trading decisions. Our results are based on experiments performed on the actual stock market data of the American and the Indian stock markets. The results indicate that the proposed model outperforms forecasting‐based methods in terms of profitability. We also limit risk by confirming trading actions with the trend before actual trading.