Miracle-dz/UniFAR-FTUs huggingface dataset:
Kisspeptin-neuron control of LH pulsatility and ovulation

Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the physiological menstrual cycle including the release of gonadotrophins to stimulate follicular growth, and the mid-cycle luteinising hormone (LH) surge that leads to ovulation. E2 predominantly exerts its action via oestrogen receptor-alpha (ERα), however, as gonadotrophin releasing hormone (GnRH) neurons lack ERα, E2-feedback is posited to be indirectly mediated via upstream neurons. Kisspeptin (KP) is a neuropeptide expressed in hypothalamic KP-neurons that control GnRH secretion and plays a key role in the central mechanism regulating the hypothalamic-pituitary-gonadal (HPG) axis. In the rodent arcuate (ARC) nucleus, KP is co-expressed with Neurokinin B and Dynorphin; and thus, these neurons are termed ‘Kisspeptin-Neurokinin B-Dynorphin’ (KNDy) neurons. ARC KP-neurons function as the ‘GnRH pulse generator’ to regulate GnRH pulsatility, as well as mediating negative feedback from E2. A second KP neuronal population is present in the rostral periventricular area of the third ventricle (RP3V), which includes anteroventral periventricular (AVPV) nucleus and preoptic area neurons. These RP3V KP-neurons mediate positive feedback to induce the mid-cycle luteinising hormone (LH) surge and subsequent ovulation. Here, we describe the role of KP-neurons in these two regions in mediating this differential feedback from oestrogens. We conclude by considering reproductive diseases for which exploitation of these mechanisms could yield future therapies.
The well-being of head start teachers: a scoping literature review

ABSTRACT Attention to students’ socio-emotional, behavioral, and academic outcomes raises important considerations for the psychological well-being of teachers, especially Head Start teachers who often work with underserved families. This scoping review summarizes current literature on Head Start teacher psychological well-being and identifies 1. how teacher well-being is conceptualized and measured, 2. Which interventions exist to promote Head Start teacher psychological well-being or help them manage stress and 3. directions for future research. The review resulted in 32 articles (29 peer-reviewed and three gray literature). Findings highlight that research is primarily descriptive using cross-sectional surveys and secondary data. Evidence suggests that although resilient and committed as educators, Head Start teachers struggle to cope with the stressors involved in supporting early childhood education. Interventions to decrease stress and promote the psychological well-being are few but teachers indicate interest in such interventions. Autonomy, feeling valued for their work, collegiality between staff, and a supportive supervisor help improve job satisfaction, retention, and psychological well-being. Future research should be guided by conceptual models that prioritize Head Start teachers’ input, use of validated measures of psychological well-being with consideration of cultural and structural factors that influence well-being.
ANALISIS PENGARUH EFEKTIFITAS DEWAN KOMISARIS DAN KOMITE AUDIT TERHADAP KUALITAS SUSTAINABILITY REPORT

This study examine the effect of Board of Commissioner’s Effectiveness, as measured by ther size, gender diversity and board of commissioners’s education and the Audit Committee’s Effectiveness as measured by size, number of meetings, and the audit committes’s accounting education onthe quality of sustainability report. This study uses the secondary data from mining companies from 2015 to 2019 from IDX. The sample selection method used is purposive sampling, obtained 12 companies with total of 43 sample. The analytical method used is multiple regression analysis with SPSS 26. The results showed that the size of board of commissioners, the gender diversity of the board of the commissioners, the education of the board of the commissioners, the size of the audit committee had no effect on the audit quality of the sustainability report so that all of the hypotheses that had been made were rejected.
Allergen immunotherapy for food allergy: Evidence and outlook

Food allergy represents a significant health issue characterized by a sizeable epidemiological burden, involving up to 5% of adults and up to 8% of children in the Western world. The elimination diet of the trigger food is the cornerstone of food allergy management. However, novel treatment options are most wanted to provide alternative strategies for this potentially fatal medical condition. Allergen immunotherapy for food allergy (FA-AIT) is considered an immunomodulatory intervention where regular exposure to increasing doses of food is performed in the context of an allergist’s supervised protocol. The main objective is to decrease reactivity, attenuate life-threatening allergic episodes and reduce frequent access to the emergency department. Achieving food tolerance off-treatment is, however, the ultimate aim. In this review, we aim to summarize FA-AIT evidence and outlook.
Determination of Delay Parameters in 4G LTE Cellular Mobile Networks

The growing interest in using mobile cellular networks to control and monitor ground and air transport poses the challenge of quantifying the delays in a selected cellular operator network against delay requirements. A simple approach is needed both to the evaluation of experimentally obtained delay values, their description and, consequently, modeling. The purpose of this article is to propose a simple method for describing delays in an 4G LTE cell, as well as to evaluate the resulting errors in estimating the average and maximum delays, as well as jitter. The paper is focused on delays considering “sufficient” quality of a radio signal. The quality of mobile cellular network coverage is out of the scope of this paper and in a particular area should be assessed separately.
CONVECTION HEAT TRANSFER IN CONCENTRIC ANNULI

A comparative study is presented of literature involving convective heat transfer in annuli. It is shown that more research is needed in the area of convective heat transfer correlations in concentric annuli, as little agreement is found among existing correlations. A correlation predicting Nusselt numbers in annuli with ratios ranging from 1.7 to 3.2 was developed experimentally for water as fluid. The correlation has an accuracy of 3% in terms of experimental values for a Reynolds number range, based on the hydraulic diameter, of 4,000 to 30,000. The correlation was also compared to numerical predictions
Peptide-Based [68Ga]Ga Labeled PET Tracer for Tumor Imaging by Targeting Tumor-Associated Macrophages

Tumor-associated macrophages (TAMs) are known to promote cancer development and metastasis. In this study, a TAMs-targeting peptide named M2pep was selected to investigate the feasibility of [68Ga]Ga-labeled M2pep as a noninvasive probe in targeted TAMs imaging. The peptide M2pep was conjugated with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and radiolabeled with 68Ga. The cellular uptake and binding assay were assessed in M2 macrophages and in the B16F10 cell line. Micro-PET imaging and a biodistribution study were performed on B16F10 tumor-bearing mice. High radiochemical purity [68Ga]Ga-DOTA-M2pep (>95%) was prepared and was stabilized in saline and bovine serum at 37 °C for 2 h. In vitro studies demonstrated high uptake of [68Ga]Ga-DOTA-M2pep in M2 macrophages, which was effectively blocked by the “cold” M2pep (free peptide). The micro-PET imaging and biodistribution study revealed that [68Ga]Ga-DOTA-M2pep reached the tumor site rapidly and showed high accumulation in the tumor at 1 h post-injection. In addition, the probe was rapidly cleared from the blood and mainly excreted via the kidneys, resulting in a high tumor/background ratio. Preclinical studies have shown that [68Ga]Ga-DOTA-M2pep specifically targets TAMs and might be a promising molecular probe for the noninvasive visualization of TAMs expression.
Speech therapy consequences associated with COVID-19: a review

The novel coronavirus (SARS-CoV-2), responsible for the COVID-19 pandemic, causes a respiratory infection disease of rapid transmission through droplets in the air, from person to person, or by contact with contaminated surfaces. Infected people can be asymptomatic or symptomatic, with symptoms like pneumonia, which can lead to hospitalization of these patients. The role of speech therapists in the multiprofessional team has been extremely important in dealing with the pandemic, especially in symptomatic and intubated patients. After extubation, these patients can be affected by serious speech-language pathology consequences, requiring follow-up for rehabilitation with a speech-language therapist. Thus, the aim of this study was to carry out, in an unprecedented way, a review in the literature about the consequences of COVID-19 in the major areas of speech therapy. To meet this objective, a narrative review was carried out, from which it was possible to analyze the major areas of speech therapy in which patients had consequences during or after the COVID-19 infection, such as difficulties in swallowing (dysphagia), tracheostomy, tinnitus, hearing loss, language, and speech delay. It was also possible to present the importance of telephonoaudiology to accompanying patients. Given the above, from the data of this review, it was possible to observe that most of the consequences associated with COVID-19 dealt with the same context: after or during the period of infection, where patients were affected by speech-language pathology consequences which required intervention to assess, rehabilitate and, when necessary, apply appropriate therapy. Furthermore, future investigations, such as randomized clinical trials, are encouraged to better elucidate these consequences, since some information is still found in studies with low scientific evidence such as case reports.
A Novel Enhanced Total Gradient (ETG) for Interpretation of Magnetic Data

Edge detection techniques identify the horizontal extents of the underground geological bodies and work well in association with magnetic as well as seismic data. Even though the detected edges might not be a lithological contact, they offer first-hand information regarding various rocks that ultimately offers an extra argument for existing tectonics. Most of the edge enhancement techniques depend either on the horizontal gradient or total gradient of the potential fields. As of now, no single edge detection filter performance is best in all conditions. The study proposes a novel edge detection filter called “ETG-Enhanced Total Gradient” that combines the derivatives of the analytic signal (AS) (in the third dimension). The maximum amplitude of the AS is less dependent of the direction of magnetization and is critical in mapping the borders of the buried magnetic sources beneath the Earth. As the ETG filter is based on the total gradient of the field, there is no need to apply reduction to the pole process on the magnetic data. One limitation of the method is that the filter is unable to perform better at the corners where the other conventional methods miserably failed. The filter’s behavior is examined and validated using 2D and 3D synthetic magnetic data. The reliability of the ETG filter is examined by applying it to the magnetic data of the Seattle uplift region, USA. A new structural map of the region is generated by using the proposed ETG filter. The observed peak response of the ETG filter is well correlated with major tectonic features such as the Seattle Fault Zone (SFZ), Hood Canal Fault (HCF), and Dewatto Fault (DF).
Morpho-agronomic and leaf anatomical traits in Coffeacanephora genotypes

ABSTRACT: Genetic variability is the basis for coffee genetic breeding. This study evaluated the potential of leaf anatomy and morpho-agronomic traits in studies of genetic variability in C. canephoracultivars. Ten genotypes were distributed in randomized block designs with three replicates. Significant differences among genotypes were detected by F-test (P < 0.05) for 13 of 15 evaluated traits. These results evidenced the heterogeneity of the studied cultivars, which is essential in composition of genetic basis in breeding programs. The Scott-Knott test detected variability among genotypes, grouped into up to four mean groups. Leaf anatomy traits presented the largest variations. Five out of seven leaf anatomy traits presented heritability higher than 80%, with emphasis on stomatal density (95.69%) and stomatal pore length (92.72%). Positive correlations were observed among morpho-agronomic and anatomic traits. Cluster analysis used the Mahalanobis general distance (D2) as a measure of genetic dissimilarity and divided the genotypes into two distinct groups. The inclusion of leaf anatomic traits to characterize C. canephoragenotypes may assist plant breeders with better genetic discrimination and with greater security in plant selection when composing cultivars.
Wearer Experience and Eye Care Professional Acceptance with a 1 Day Multifocal Contact Lens

Purpose A large observational survey was undertaken to determine eye care professional (ECP) and patient experience of stenfilcon A multifocal soft contact lens (MyDay multifocal) when prescribed in a real-world setting. Methods A total of 196 ECPs from eleven countries fit up to ten presbyopes with stenfilcon A multifocal. Data were collected on fit success at the initial visit, patient satisfaction with comfort, vision at distance, intermediate, and near, overall vision, overall satisfaction, and handling at the initial and follow-up visits after 1–2 weeks of wear. ECPs completed questionnaires on multifocal fitting experience and expectations before and after the fitting period. Results A total of 196 pre-fitting and 141 post-fitting ECP surveys were collected. A total of 1505 initial fits (mean age 53.4, range 38 to 81 years, 73% female, 27% neophytes) and 1440 follow-up visits were completed. The mean distance vision contact lens prescription was −1.32DS (range −12.00DS to +8.00DS) with Add powers: Low 56%, Medium 24%, and High 21%. At the follow-up visit 77% (n=1108) of trials were successful. Mean patient satisfaction ratings (1–10 scale, where 1 is not at all satisfied, and 10 extremely satisfied) at the initial visit were higher than eight out of ten for comfort, vision, and overall satisfaction, and were not significantly different after 1–2 weeks of wear. Stenfilcon A multifocal was preferred by 66% of patients over their habitual correction. In most cases mean satisfaction scores and the proportion of patients highly satisfied were not significantly different between myopes and hyperopes, across Add range, between new and habitual wearers, and wearers of frequently replaced and 1 day contact lenses. Conclusion ECPs in real-world clinical settings found stenfilcon A multifocal contact lenses easy to fit to a wide range of patients, with a high fit success rate and high levels of patient satisfaction for overall comfort, vision, satisfaction, and handling.
Tumor Immunogenic Cell Death as a Mediator of Intratumor CD8 T-Cell Recruitment

The success of anticancer treatments relies on a long-term response which can be mediated by the immune system. Thus, the concept of immunogenic cell death (ICD) describes the capacity of dying cancer cells, under chemotherapy or physical stress, to express or release danger-associated molecular patterns (DAMPs). These DAMPs are essential to activate dendritic cells (DCs) and to stimulate an antigen presentation to CD8 cytotoxic cells. Then, activated CD8 T cells exert their antitumor effects through cytotoxic molecules, an effect which is transitory due to the establishment of a feedback loop leading to T-cell exhaustion. This phenomenon can be reversed using immune checkpoint blockers (ICBs), such as anti-PD-1, PD-L1 or CTLA-4 Abs. However, the blockade of these checkpoints is efficient only if the CD8 T cells are recruited within the tumor. The CD8 T-cell chemoattraction is mediated by chemokines. Hence, an important question is whether the ICD can not only influence the DC activation and resulting CD8 T-cell activation but can also favor the chemokine production at the tumor site, thus triggering their recruitment. This is the aim of this review, in which we will decipher the role of some chemokines (and their specific receptors), shown to be released during ICD, on the CD8 T-cell recruitment and antitumor response. We will also analyze the clinical applications of these chemokines as predictive or prognostic markers or as new targets which should be used to improve patients’ response.
Effect of Zn:S molar ratio in solution on the properties of ZnS thin films and the formation of ZnS nanorods by spray pyrolysis

The ZnS layers morphology, structure, composition, and optical properties were investigated with respect to the precursors (zinc chloride and thiocarbamide, Zn:S) molar ratio in spray solution (1:1, 1:2, and 1:3) and growth temperatures in the range of 400–600 °C. Scanning electron microscopy (SEM), X‐ray diffraction (XRD), energy dispersive X‐ray analysis (EDX), UV–VIS, and PL spectroscopy were applied to characterize the ZnS layers. Layers obtained at temperatures up to 450 °C are not well crystallized and contain residues originated from undecomposed precursors. ZnS films become crystalline at Ts = 500 °C. Layers grown from 1:1 solution at 550 °C are mixture of ZnS and ZnO phases, whereas at 600 °C layers of ZnO were obtained. Films produced from 1:2 solution at 500–600 °C are of ZnS with a wurtzite structure and Eg of 3.66 eV, but contain traces of ZnO phase when grown at 550 or 600 °C. Appearance of ZnO phase in the films grown from 1:1 and 1:2 solutions is explained by the results of the studies on the formation and decomposition of dichlorobis(thiocarbamide)zinc(II) complex as an intermediate compound formed in the solution of zinc chloride and thiocarbamide. Spraying the solutions with Zn:S = 1:3, which contain more thiocarbamide than required for the complex formation, results in single‐phase ZnS layers with wurtzite structure at growth temperatures up to 600 °C. Moreover, ZnS layers obtained from 1:3 solution at 550 °C and higher are composed of highly c‐axis oriented ZnS nanorod‐like crystals with diameter of ca. 80 nm and length of ca. 300 nm.
A SIMPLE OBSERVATION ABOUT COMPACTNESS AND FAST DECAY OF FOURIER COEFFICIENTS

Let X be a Banach space and suppose YX is a Banach space compactly embedded into X, and (ak) is a weakly null sequence of functionals in X � . Then there exists a sequence f"ng & 0 such that jan(y)j � "nkykY for every n 2 N and every y 2 Y. We prove this result and we use it for the study of fast decay of Fourier coefficients in L p (T) and frame coefficients in the Hilbert setting. 1. Motivation One of the classical problems in Harmonic Analysis is the study of the relationship that exists between decay properties of the Fourier coefficientscn(f) = 1 2� R 2� 0 f(t)e int dt of a 2�-periodic function f : T ! C and its membership to several function spaces. Just to mention a few well known examples, we show the following list of results: � Riemann-Lebesgue Lemma sates that for f 2 L 1 (T) the Fourier coefficients satisfy limn! ±1 jcn(f)j= 0. � Parseval's identity states that f 2 L 2 (T) if and only if fcn(f)g 2 ` 2 (Z). � For 1 2 and f 2 L p (T), then f 2 L 2 (T) and fcn(f)g 2 ` 2 (Z).
Predicting risk factors for hypothyroidism after definitive radiotherapy for early glottic carcinomas

Hypothyroidism may occur after definitive radiotherapy in rare cases of early glottic carcinoma. However, to the best of our knowledge, no study to date has examined the risk factors for hypothyroidism specifically after definitive radiotherapy in patients with early glottic carcinoma. The present study determined risk factors for hypothyroidism after definitive radiotherapy in patients with early glottic carcinoma. This was a retrospective study that included 73 patients with T1 or T2, N0 glottic squamous cell carcinoma who underwent radiotherapy between June 3, 2009 and December 25, 2020. Demographic and clinical characteristics, including age, sex, tumor stage and pretreatment thyroid volume, were examined to elucidate the clinical risk factors for hypothyroidism. Field size, total prescribed dose and thyroid receiving dose were evaluated as dosimetric risk factors for hypothyroidism. Irradiated underlying thyroid volumes of more than 5, 10, 20, 30, 40, 50, 60 and 65 Gy (V5Gy, V10Gy, V20Gy, V30Gy, V40Gy, V50Gy, V60Gy and V65Gy) and mean thyroid dose were included as thyroid receiving doses. The median follow-up duration was 61 months (range, 7–150 months). Hypothyroidism was present in 15 (21%) of the 73 patients, including 12 and 3 patients with grade 1 and 2 hypothyroidism, respectively. Among the demographic and clinical factors, sex and pretreatment thyroid volume were significantly associated with hypothyroidism (P=0.007 and P<0.001, respectively). Among the dosimetric factors, the presence of hypothyroidism was significantly associated with V5Gy (P=0.012), V10Gy (P=0.015), V20Gy (P=0.020), V30Gy (P=0.024), V40Gy (P=0.028), V50Gy (P=0.028), V60Gy (P=0.027) and mean thyroid dose (P=0.023). In conclusion, sex, pretreatment thyroid volume and thyroid receiving dose were associated with hypothyroidism after definitive radiotherapy in patients with early glottic carcinoma. Particularly, the receiving dose to the thyroid gland should be reduced in female patients and in those with small thyroid volumes who are at higher risk for hypothyroidism following radiotherapy.
Direct products and the contravariant hom‐functor

We prove in Zermelo–Fraenkel set theory with the axiom of choice (ZFC) that if G is a (right) R‐module such that the groups HomR(∏i∈IGi, G) and ∏i∈I HomR(Gi, G) are naturally isomorphic for all families of R‐modules (Gi)i∈I, then G=0. The result is valid even if we restrict to families such that Gi≅ G for all i∈I.
Predictive Factors of Adequate Bowel Cleansing for Colonoscopy in the Elderly: A Retrospective Analysis of a Prospective Cohort

Factors affecting the quality of bowel preparation for colonoscopy in the elderly are not fully known, and current guidelines provide no specific recommendations. This study aimed to assess the difference in bowel cleansing in young and elderly patients and evaluate predictors of bowel cleansing in the elderly. We retrospectively reviewed a prospective cohort of 1289 patients performing colonoscopy after a 1-, 2-, or 4-L PEG-based preparation. All 1289 were included in the analysis. Overall, 44.6% of patients were aged ≥65 years. Cleansing success (CS) was achieved in 77.3% and 70.3% of patients aged <65 years and ≥65 years, respectively. At multivariable analysis, split regimen (OR = 2.43, 95% CI = 1.34–4.38; p = 0.003), adequate cleansing at previous colonoscopy (OR = 2.29, 95% CI = 1.14–4.73; p = 0.02), tolerability score (OR = 1.29, 95% CI = 1.16–1.44; p < 0.001), a low-fiber diet for at least 3 days (OR = 2.45, 95% CI = 1.42–4.24; p = 0.001), and colonoscopy within 5 h after the end of preparation (OR = 2.67, 95% CI = 1.28–5.56; p = 0.008) were independently associated with CS in the elderly. Combining a low-fiber diet for at least 3 days, split preparation, and colonoscopy within 5 h allowed a CS rate above 90% and should always be encouraged. A 1-L PEG-ASC preparation was also associated with greater high-quality cleansing of the right colon and may be preferred.