Miracle-dz/UniFAR-FTUs huggingface dataset:
Socioeconomic effect of education on pancreatic cancer risk in Western Europe: an update on the EPIC cohort Study Social effect on pancreatic cancer risk updated in Europe

words Aim : To analyze the potential effect of social inequality on pancreatic cancer (PC) risk in Western Europe, by re-assessing the association within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, including a larger number of cases and an extended follow-up. Methods : Data on highest education attained was gathered for 459,170 participants (70% women) from ten European countries. A relative index of inequality (RII) based on adult education was calculated for comparability across countries and generations. Cox regression models were applied to estimate relative inequality in PC risk, stratifying by age, gender, and center, and adjusting for known PC risk factors. Results : A total of 1,223 incident PC cases were included after a mean follow-up of 13.9 (± 4.0) years. An inverse social trend was found in models adjusted for age, sex, and center for both sexes combined (HR = 1.27, 95% confidence interval (CI): 1.02 to 1.59), which was also significant among women (1.42, 1.05 to 1.92) but not among men. However, further adjusting the models by smoking intensity, alcohol consumption, body mass index, prevalent diabetes, and physical activity, led to an attenuation of the RII risk and loss of statistical significance. Conclusion : The present re-analysis does not support the existence of an independent social inequality influence on pancreatic cancer risk in Western European women and men, using an index based on adult education, the most relevant social indicator linked to individual lifestyles, in a context of very low PC survival from (quasi) universal public health systems.
for Processing Visual Information.

Some Methodological Considerations and Strategies The ability of adults to process visual Information varying on the dimensions of color, symmetry, and information load, was investigated in the present study by means of a recognition task. The subjects were 15 males and 17 females associated with the University of North Carolina at Greensboro. Prior to the onset of the actual experiment, all subjects were given familiarity with stimulus slides, similar to, but different from those used In the study. During training the subjects' task was to simply look at each slide as It appeared on the screen, noting its colors, symmetry, number, and position of stripes filled in with color in each pattern. the the alternatives
Bear with me: Understanding motivations for bear farming in Vietnam

Bears were once farmed legally across Vietnam to supply bile, a digestive fluid, as an ingredient for traditional medicine products. Extracting and selling bear bile has been prohibited in Vietnam since 2005, but there is evidence that an illegal industry remains active. The aim of this study is to gain insight into the motivations and experiences of Vietnamese bear farmers. Thirty-seven semi-structured interviews were conducted with 28 active and 9 former bear farmers across 14 provinces in Vietnam. Our findings confirm previous reports in the literature that there is still an active, illegal bear bile market in Vietnam, but that bear farming is becoming less profitable due to a reduction in demand for farmed products and the decreasing price of bile. Additional results indicate that many Vietnamese bear farmers may have a poor understanding of regulations governing the trade of bear parts and that most farmers do not intend to stop farming bears. Based on these findings, we suggest the most effective method of persuading bear farmers to stop trading bile would be via former bear farmers and to reduce the social acceptability of bile consumption throughout the country. We hope the results of this study can help refine strategies and inform future efforts to end the bear bile industry in Vietnam.
CDKN2A-mediated molecular subtypes characterize the hallmarks of tumor microenvironment and guide precision medicine in triple-negative breast cancer

Currently, breast cancer (BRCA) has become the most common cancer in the world, whose pathological mechanism is complex. Among its subtypes, triple-negative breast cancer (TNBC) has the worst prognosis. With the increasing number of diagnosed TNBC patients, the urgent need of novel biomarkers is also rising. Cyclin-dependent kinase inhibitor 2A (CDKN2A) has recently emerged as a key regulator associated with ferroptosis and cuproptosis (FAC) and has exhibited a significant effect on BRCA, but its detailed mechanism remains elusive. Herein, we conducted the first converge comprehensive landscape analysis of FAC-related gene CDKN2A in BRCA and disclosed its prognostic value in BRCA. Then, an unsupervised cluster analysis based on CDKN2A-correlated genes unveiled three subtypes, namely cold-immune subtype, IFN-γ activated subtype and FTL-dominant subtype. Subsequent analyses depicting hallmarks of tumor microenvironment (TME) among three subtypes suggested strong association between TNBC and CDKN2A. Given the fact that the most clinically heterogeneous TNBC always displayed the most severe outcomes and lacked relevant drug targets, we further explored the potential of immunotherapy for TNBC by interfering CDKN2A and constructed the CDKN2A-derived prognostic model for TNBC patients by Lasso-Cox. The 21-gene–based prognostic model showed high accuracy and was verified in external independent validation cohort. Moreover, we proposed three drugs for TNBC patients based on our model via targeting epidermal growth factor receptor. In summary, our study indicated the potential of CDKN2A as a pioneering prognostic predictor for TNBC and provided a rationale of immunotherapy for TNBC, and offered fresh perspectives and orientations for cancer treatment via inducing ferroptosis and cuproptosis to develop novel anti-cancer treatment strategies.
Successful wayfinding in age: A scoping review on spatial navigation training in healthy older adults

Introduction Spatial navigation is a complex cognitive function that declines in older age. Finding one’s way around in familiar and new environments is crucial to live and function independently. However, the current literature illustrates the efficacy of spatial navigation interventions in rehabilitative contexts such as pathological aging and traumatic injury, but an overview of existing training studies for healthy older adults is missing. This scoping review aims to identify current evidence on existing spatial navigation interventions in healthy older adults and analyze their efficacy. Methods To identify spatial navigation interventions and assessments and investigate their effectiveness, four electronic databases were searched (Pubmed, Web of Science, CINAHL and EMBASE). Two independent reviewers conducted a screening of title, abstract and full-texts and performed a quality assessment. Studies were eligible if (1) published in English, (2) the full text was accessible, (3) at least one group of healthy older adults was included with (4) mean age of 65 years or older, (5) three or more spatial navigation-related training sessions were conducted and (6) at least one spatial ability outcome was reported. Results Ten studies were included (N = 1,003, age-range 20–95 years, 51.5% female), only healthy older adults (n = 368, mean age ≥ 65) were assessed further. Studies differed in sample size (n = 22–401), type of training, total intervention duration (100 min–50 h), and intervention period (1–16 weeks). Conclusion The spatial navigation abilities addressed and the measures applied to elicit intervention effects varied in quantity and methodology. Significant improvements were found for at least one spatial ability-related outcome in six of 10 interventions. Two interventions achieved a non-significant positive trend, another revealed no measurable post-training improvement, and one study did not report pre-post-differences. The results indicate that different types of spatial navigation interventions improve components of spatial abilities in healthy older adults. The existing body of research does not allow conclusions on transferability of the trained components on everyday life spatial navigation performance. Future research should focus on reproducing and extending the promising approaches of available evidence. From this, valuable insights on healthy aging could emerge. Trial Registration This scoping review was preregistered at Open Science Framework (https://osf.io/m9ab6).
Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a dreadful novel coronavirus with global health concerns among pregnant women. To date, the vertical transmission of SARS-CoV-2 during pregnancy remains controversial. We briefly report recent findings of placental response to SARS-CoV-2 infection and updates on vertical transmission. We systematically searched PubMed and Google Scholar databases according to PRISMA guidelines for studies reporting the effects of SARS-CoV-2 infection on the placenta and possibility of vertical transmission. We identified 45 studies reporting 1,280 human placentas that were analyzed by molecular pathology methods and 11,112 placenta-derived cells from a publicly available database that was analyzed using bioinformatics tools. The main finding of this study is that the SARS-CoV-2 canonical entry receptors (ACE2 and TMPRSS2) are abundantly expressed on the placenta during the first trimester, and this expression diminishes across gestational age. Out of 45 eligible studies identified, 24 (53.34%) showed no evidence of vertical transmission, 15 (33.33%) supported the hypothesis of very rare, low possibility of vertical transmission and 6 (13.33%) were indecisive and had no comment on vertical transmission. Furthermore, 433 placentas from 12 studies were also identified for placental pathology investigation. There was evidence of at least one form of maternal vascular malperfusion (MVM), 57/433 (13.1%), fetal vascular malperfusion (FVM), 81/433 (18.7%) and placental inflammation with excessive infiltration of CD3+ CD8+ lymphocytes, CD68+ macrophages and CD20+ lymphocytes in most of the eligible studies. Decidual vasculopathy (3.2%), infarction (3.2%), chronic histiocytic intervillositis (6.0%), thrombi vasculopathy (5.1%) were also observed in most of the MVM and FVM reported cases. The results indicated that SARS-CoV-2 induces placenta inflammation, and placenta susceptibility to SARS-CoV-2 decreases across the pregnancy window. Thus, SARS-CoV-2 infection in early pregnancy may adversely affect the developing fetus.
Parental psychological distress and child maladjustment: Exploring the moderating role of sibling relationship quality

The aim of this study was to investigate whether the quality of the sibling relationship moderates the association between parental psychological distress and child maladjustment (i.e., internalizing and externalizing problems). We extended previous literature by studying mothers and fathers separately and by including an observational measure of the quality of the sibling relationship. Participants were 52 two-parent families from a community sample who had at least two children living at home. Only one child (aged 6–10 years) was targeted for the study and studied in relation to his/her siblings. Mothers and fathers completed a self-reported questionnaire on their psychological distress and individually assessed their child’s social-emotional maladjustment. The targeted child’s interactions with his/her siblings were observed by independent judges during a home-visit. Results indicate that both maternal and paternal psychological distress are significant predictors of child social-emotional maladjustment. Moderation analyses reveal that children of distressed fathers are at lower risk of social-emotional maladjustment when they engage in highly positive interactions with their siblings. Post hoc analyses suggest that only sibling empathy (not teaching nor companionship) is a significant moderator of the association between paternal psychological distress and child maladjustment. The results of this study provide further evidence of the influence that fathers have in their child’s development and highlight the importance of using a systemic family approach to promote children’s social-emotional adaptation in the context of parental distress.
The role of physiotherapy in fibromyalgia: Current and future perspectives

Fibromyalgia is a chronic pain condition characterized by generalized musculoskeletal pain, hyperalgesia and allodynia, commonly associated with other symptoms such as fatigue, poor sleep quality, anxiety and depression. The clinical manifestations of this rheumatic disease have significant psychosocial and economic repercussions, with a substantial impact on health status, quality of life and social activities. Currently, recommendations for the management of fibromyalgia include patient education and non-pharmacological interventions, and among the indicated treatments, clinical guidelines include several physiotherapeutic resources, essential for individuals affected by this syndrome. Research in the physiotherapy field has demonstrated its effectiveness, but there is a need to update the literature. This study aims to identify the effectiveness of physiotherapy in the treatment of individuals with fibromyalgia. We performed a literature review looking for articles dated from March 2012 to March 2022 using the terms “fibromyalgia”, “physiotherapy”, “physical therapy”, “rehabilitation” in different languages in various databases and their main information was read and collected and presented in a descriptive way. The effects of physiotherapy interventions are summarized in order to provide a reference for future research and clinical application. Research on non-pharmacological physiotherapy-oriented treatments has grown in recent years as an alternative for fibromyalgia treatment. This review allows fibromyalgia patients to receive appropriate physical therapy interventions to promote their health.
Atonal homolog 8/Math6 regulates differentiation and maintenance of skeletal muscle

Atonal Homolog 8 (Atoh8) belongs to a large superfamily of transcriptional regulators called basic helix-loop-helix (bHLH) transcription factors. Atoh8 (murine homolog “Math6”) has been shown to be involved in organogenesis during murine embryonic development. We have previously identified the expression of Atoh8 during skeletal myogenesis in chicken where we described its involvement in hypaxial myotome formation suggesting a regulatory role of Atoh8 in skeletal muscle development. Within the current study, we analyzed the effect of the loss of function of Atoh8 in murine primary myoblasts and during differentiation of pluripotent stem cells into myotubes, and the effect of its gain of function in C2C12 cells. Based on the observed results, we conclude that Atoh8 regulates myoblast proliferation via modulating myostatin signaling. Further, our data revealed a reduced muscle mass, strength and fiber size with significant changes to the muscle fiber type suggesting atrophy in skeletal muscle of Atoh8 mutants. We further report that Atoh8 knockout mice suffer from a condition similar to ambient hypoxia which may be the primary cause of the phenotype. Altogether, this study shows the significance of Atoh8 not only in myogenesis but also in the maintenance of skeletal muscle.
Testing of pandemic ventilators under early and agile development

Aiming to address clinical requirements subsequent to SARS-CoV-2-related pulmonary disease, multiple research groups and industry groups carried out intensive studies to develop pandemic ventilators (PDVs). In vitro testing to critically evaluate the specific performance of the developed apparatuses is an essential requirement. This study presents a test protocol which promotes a test-oriented, iterative, and agile assessment and consecutive development of such PDVs. It allows for fast identification of specific characteristics of each PDV in the individual test features. The test protocol includes an evaluation of the accuracy of control systems and instruments at changing parameters, the oxygen dynamics, and the response to trigger signals. The test environment is a mechanical lung, which allows reproducing various lung mechanics and to simulate active breathing cycles. A total of three PDVs that are under development were iteratively tested, with a Hamilton T1 as a reference. Continuous testing of the PDVs under development enables quick identification of critical application aspects that deserve further improved. Based on the present test protocol, the ventilators demonstrate a promising performance justifying continued development.
Computational approaches to alleviate alarm fatigue in intensive care medicine: A systematic literature review

Patient monitoring technology has been used to guide therapy and alert staff when a vital sign leaves a predefined range in the intensive care unit (ICU) for decades. However, large amounts of technically false or clinically irrelevant alarms provoke alarm fatigue in staff leading to desensitisation towards critical alarms. With this systematic review, we are following the Preferred Reporting Items for Systematic Reviews (PRISMA) checklist in order to summarise scientific efforts that aimed to develop IT systems to reduce alarm fatigue in ICUs. 69 peer-reviewed publications were included. The majority of publications targeted the avoidance of technically false alarms, while the remainder focused on prediction of patient deterioration or alarm presentation. The investigated alarm types were mostly associated with heart rate or arrhythmia, followed by arterial blood pressure, oxygen saturation, and respiratory rate. Most publications focused on the development of software solutions, some on wearables, smartphones, or headmounted displays for delivering alarms to staff. The most commonly used statistical models were tree-based. In conclusion, we found strong evidence that alarm fatigue can be alleviated by IT-based solutions. However, future efforts should focus more on the avoidance of clinically non-actionable alarms which could be accelerated by improving the data availability. Systematic Review Registration: https://www.crd. york.ac. uk/prospero/display_record. php? ID=CRD42021233461, identifier: CRD42021233461.
Transient high latitude geomagnetic response to rapid increases in solar wind dynamic pressure

Rapid changes in solar wind dynamic pressure can produce a transient geomagnetic response in the high latitude ionosphere. In this study we carry out a superposed epoch analysis of the geomagnetic response based on 2,058 events. The events are divided into 12 groups based on interplanetary magnetic field clock angle and dipole tilt and the magnetic perturbation field is modeled using spherical harmonics. We find that the high latitude transient current vortices associated with a sudden commencement are most clearly observed when the interplanetary magnetic field is northward during equinox and winter in the northern hemisphere. The high latitude geomagnetic response during northward interplanetary magnetic field is decomposed into a preliminary and main impulse. The preliminary impulse onset is 1–2 min prior to the onset of the low/mid latitude geomagnetic response and its rise time is 4–6 min. The main impulse onset is around 2 min after the low/mid latitude geomagnetic response and has a rise time of 6–11 min. When examining the change relative to pre-onset conditions a coherent transient geomagnetic response emerges for all IMF clock and dipole tilt angles. The current vortex associated with the main impulse on the dawnside appears at (9.3 ± 0.5 mlt, 64.8° ± 1.5° mlat) and moves westward with a velocity of 5 ± 1.4 km/s. The vortex on the duskside appears at (15.3 ± 0.9 mlt, 65.8° ± 2.5° mlat) and does not move significantly. In addition, the models were used to recreate the SMR index showing a significant mlt dependence on the magnetic perturbation above 40° mlat and below 10° mlat. The former is thought to be caused by high latitude ionospheric currents. The latter is potentially a combination of the event occurrence probability being skewed toward certain UT ranges for large dipole tilt angles and a UT dependence of the equatorial electrojet magnitude caused by the south atlantic magnetic anomaly.
Entner-Doudoroff pathway in Synechocystis PCC 6803: Proposed regulatory roles and enzyme multifunctionalities

The Entner-Doudoroff pathway (ED-P) was established in 2016 as the fourth glycolytic pathway in Synechocystis sp. PCC 6803. ED-P consists of two reactions, the first catalyzed by 6-phosphogluconate dehydratase (EDD), the second by keto3-deoxygluconate-6-phosphate aldolase/4-hydroxy-2-oxoglutarate aldolase (EDA). ED-P was previously concluded to be a widespread (∼92%) pathway among cyanobacteria, but current bioinformatic analysis estimated the occurrence of ED-P to be either scarce (∼1%) or uncommon (∼47%), depending if dihydroxy-acid dehydratase (ilvD) also functions as EDD (currently assumed). Thus, the biochemical characterization of ilvD is a task pending to resolve this uncertainty. Next, we have provided new insights into several single and double glycolytic mutants based on kinetic model of central carbon metabolism of Synechocystis. The model predicted that silencing 6-phosphogluconate dehydrogenase (gnd) could be coupled with ∼90% down-regulation of G6P-dehydrogenase, also limiting the metabolic flux via ED-P. Furthermore, our metabolic flux estimation implied that growth impairment linked to silenced EDA under mixotrophic conditions is not caused by diminished carbon flux via ED-P but rather by a missing mechanism related to the role of EDA in metabolism. We proposed two possible, mutually non-exclusive explanations: (i) Δeda leads to disrupted carbon catabolite repression, regulated by 2-keto3-deoxygluconate-6-phosphate (ED-P intermediate), and (ii) EDA catalyzes the interconversion between glyoxylate and 4-hydroxy-2-oxoglutarate + pyruvate in the proximity of TCA cycle, possibly effecting the levels of 2-oxoglutarate under Δeda. We have also proposed a new pathway from EDA toward proline, which could explain the proline accumulation under Δeda. In addition, the presented in silico method provides an alternative to 13C metabolic flux analysis for marginal metabolic pathways around/below the threshold of ultrasensitive LC-MS. Finally, our in silico analysis provided alternative explanations for the role of ED-P in Synechocystis while identifying some severe uncertainties.
Corticosterone in Commercial Broilers 1

SUMMARY The welfare of commercially produced broilers is of concern to producers and consumers. When birds are reared under stressful conditions they often exhibit several adaptive responses. The major response is secretion of the stress hormone, corticosterone (CS), by the adrenal glands. The objective of this study was to assess welfare of commercially reared broilers by determining plasma CS concentrations at various times during grow out. Results show that CS concentrations of all birds tested remained in the nonstress range. The conclusion of this study is that commercial production of broilers in tunnel-ventilated houses that maintained temperatures in the comfort zone and light at low intensities did not cause stress as measured by circulating blood levels of CS.