Miracle-dz/UniFAR-FTUs huggingface dataset:
Promotion of diet‐induced obesity and metabolic syndromes by BID is associated with gut microbiota

A growing body of evidence has indicated an expanding functional network of B‐cell lymphoma 2 (BCL‐2) family proteins beyond regulation of cell death and survival. Here, we examined the role and mechanisms of BH3 interacting‐domain death agonist (BID), a pro‐death BCL‐2 family member, in the development of diet‐induced metabolic dysfunction. Mice deficient in bid (bid−/−) were resistant to high‐fat diet (HFD)–induced obesity, hepatic steatosis, and dyslipidemia with an increased insulin sensitivity. Indirect calorimetry analysis indicated that bid deficiency increased metabolic rate and decreased respiratory exchange ratio, suggesting a larger contribution of lipids to overall energy expenditure. While expression of several genes related to lipid accumulation was only increased in wild‐type livers, metabolomics analysis revealed a consistent reduction in fatty acids but an increase in certain sugars and Krebs cycle intermediates in bid−/− livers. Gut microbiota (GM) analysis indicated that HFD induced gut dysbiosis with differential patterns in wild‐type and in bid−/− mice. Notably, abrogation of GM by antibiotics during HFD feeding eliminated the beneficial effects against obesity and hepatic steatosis conferred by the bid deficiency. Conclusion: These results indicate that the protective role of bid‐deficiency against diet‐induced metabolic dysfunction interacts with the function of GM.
Gamma ray bursts as electromagnetic outflows

(Abridged) We interpret gamma ray bursts as relativistic, electromagnetic explosions. Specifically, we propose that they are created when a rotating, relativistic, stellar-mass progenitor loses much of its rotational energy in the form of a Poynting flux during an active period lasting $\sim 100$ s. Initially, a non-spherically symmetric, electromagnetically-dominated bubble expands non-relativistically inside the star, most rapidly along the rotational axis of the progenitor. After the bubble breaks out from the stellar surface and most of the electron-positron pairs annihilate, the bubble expansion becomes highly relativistic. After the end of the source activity most of the electromagnetic energy is concentrated in a thin shell inside the contact discontinuity between the ejecta and the shocked circumstellar material. This electromagnetic shell pushes a relativistic blast wave into the circumstellar medium. Current-driven instabilities develop in this shell at a radius $\sim3\times10^{16}$ cm and lead to dissipation of magnetic field and acceleration of pairs which are responsible for the $\gamma$-ray burst. At larger radii, the energy contained in the electromagnetic shell is mostly transferred to the preceding blast wave. Particles accelerated at the forward shock may combine with electromagnetic field from the electromagnetic shell to produce the afterglow emission.
DWARF GALAXIES OF THE LOCAL GROUP

▪ Abstract The Local Group dwarf galaxies offer a unique window to the detailed properties of the most common type of galaxy in the Universe. In this review, I update the census of Local Group dwarfs based on the most recent distance and radial velocity determinations. I then discuss the detailed properties of this sample, including (a) the integrated photometric parameters and optical structures of these galaxies, (b) the content, nature, and distribution of their interstellar medium (ISM), (c) their heavy-element abundances derived from both stars and nebulae, (d) the complex and varied star-formation histories of these dwarfs, (e) their internal kinematics, stressing the relevance of these galaxies to the “dark matter problem” and to alternative interpretations, and (f) evidence for past, ongoing, and future interactions of these dwarfs with other galaxies in the Local Group and beyond. To complement the discussion and to serve as a foundation for future work, I present an extensive set of basic observ.
Applying multilevel analysis and the Driver Behavior Questionnaire (DBQ) on unsafe actions under a road safety policy

The aims of this research are: to investigate and develop a multilevel analysis of unsafe actions or risky behaviors; to study the influence of road safety policy factors on risky behaviors; and to analyze personal characteristics that influence risky behaviors. Data were collected using 1,474 samples from locations countrywide at the district level, including 76 clusters, via the Driver Behavior Questionnaire (DBQ) and road safety policy. The results indicate that, for the district-level model, the participation factor directly and negatively influenced risky behaviors, and government support indirectly had a negative impact through participation. Thus, people’s participation in the area caused a decrease in unsafe behaviors. Meanwhile, safety policy support in the area partially caused people to participate at a significant level. At the personal level, income, having a driver’s license, past violations, and past accidents significantly affected risky behaviors, especially having a driver’s license, which had a negative influence. This meant that people who had a driver’s license facilitated a positive effect in terms of decreasing risky behaviors, while people with past violations and past accidents influenced this situation positively. The more traffic law violations and accidents the participants had, the more they engaged in unsafe actions. Based on the findings, acknowledging and solving the problem of unsafe driving at a spatial level can address the issue by supporting different measures to help people in the area improve the situation. In addition, we should assist people who have a driver’s license by offering them useful training to decrease traffic law violations and inform them about accidents.
Simulating galaxies in the reionization era with FIRE-2: morphologies and sizes

We study the morphologies and sizes of galaxies at z>5 using high-resolution cosmological zoom-in simulations from the Feedback In Realistic Environments project. The galaxies show a variety of morphologies, from compact to clumpy to irregular. The simulated galaxies have more extended morphologies and larger sizes when measured using rest-frame optical B-band light than rest-frame UV light; sizes measured from stellar mass surface density are even larger. The UV morphologies are usually dominated by several small, bright young stellar clumps that are not always associated with significant stellar mass. The B-band light traces stellar mass better than the UV, but it can also be biased by the bright clumps. At all redshifts, galaxy size correlates with stellar mass/luminosity with large scatter. The half-light radii range from 0.01 to 0.2 arcsec (0.05-1 kpc physical) at fixed magnitude. At z>5, the size of galaxies at fixed stellar mass/luminosity evolves as (1+z)^{-m}, with m~1-2. For galaxies less massive than M_star~10^8 M_sun, the ratio of the half-mass radius to the halo virial radius is ~10% and does not evolve significantly at z = 5-10; this ratio is typically 1-5% for more massive galaxies. A galaxy's "observed" size decreases dramatically at shallower surface brightness limits. This effect may account for the extremely small sizes of z>5 galaxies measured in the Hubble Frontier Fields. We provide predictions for the cumulative light distribution as a function of surface brightness for typical galaxies at z = 6.
Application of multicolour reflectance imaging for the characterisation of inherited retinal disorders

Aim To describe the role of multicolour reflectance images (MCI) in the phenotypic diagnosis of inherited retinal disorders (IRDs). Methods A retrospective review of consecutive patients affected by IRDs examined with MCI techniques from January to December 2019 at a tertiary care referral centre. All patients had MCI, fundus autofluorescence and optical coherence tomography taken at the same time point. The ability of each modality to highlight clinical features was assessed. Lesions’ size was also measured and compared among imaging modalities. Results Thirty eyes of 15 patients were included in the study, 6 males and 9 females, with a mean age of 44 years (range: 19–57.5). The most frequent clinical diagnosis were: pattern dystrophies, and late-onset retinal degeneration. Next-generation or Sanger sequencing analysis was carried out in all patients. Blue and green reflectance were relevant in highlighting peripheral mottling in fundus albipunctatus, pseudoreticular drusen in late-onset retinal degeneration, parafoveal hyperreflective area in bull's eye maculopathy and crystals in Bietti's crystalline dystrophy. Likewise, it is to mention the ability of infrared reflectance to detect hyperreflective patches in posterior pole in neurofibromatosis type 1 and retinal changes in pattern dystrophies and cone dystrophies. Conclusion Multicolour imaging technique enables the detection of clinical features that could be overlooked by other imaging modalities, allowing accurate phenotypic characterisation of IRDs and guiding genetic diagnose, and may become a meaningful monitoring tool for future treatments.
Targeting aloe active compounds to c-KIT promoter G-quadruplex and comparative study of their anti proliferative property

Abstract Small molecules targeting G-quadruplex of oncogene promoter is considered as a promising anticancer therapeutics approach. Natural aloe compounds aloe emodin, and its glycoside derivative aloe emodin-8-glucoside and aloin have anticancer activity and also have potential DNA binding ability. These three compounds have promising binding ability towards quadruplex structures particularly c-KIT G-quadruplex. Here, this study demonstrates complete biophysical study of these compounds to c-KIT quadruplex structure. Aloe emodin showed highest binding stabilization with c-KIT which has been proved by absorbance, fluorescence, dye displacement, ITC and SPR studies. Moreover, comparative study of these compounds with HCT 116 cells line also agreed to their anti proliferative property which may be helpful to establish these aloe compounds as potential anticancer drugs. This study comprises a complete biophysical study along with their anti proliferative property and demonstrates aloe emodin as a potent c-KIT binding molecule. Graphical Abstract Communicated by Ramaswamy H. Sarma
RANDOM SPARSE SAMPLING IN A GIBBS WEIGHTED TREE AND PHASE TRANSITIONS

Let $\unicode[STIX]{x1D707}$ be the projection on $[0,1]$ of a Gibbs measure on $\unicode[STIX]{x1D6F4}=\{0,1\}^{\mathbb{N}}$ (or more generally a Gibbs capacity) associated with a Hölder potential. The thermodynamic and multifractal properties of $\unicode[STIX]{x1D707}$ are well known to be linked via the multifractal formalism. We study the impact of a random sampling procedure on this structure. More precisely, let $\{{I_{w}\}}_{w\in \unicode[STIX]{x1D6F4}^{\ast }}$ stand for the collection of dyadic subintervals of $[0,1]$ naturally indexed by the finite dyadic words. Fix $\unicode[STIX]{x1D702}\in (0,1)$ , and a sequence $(p_{w})_{w\in \unicode[STIX]{x1D6F4}^{\ast }}$ of independent Bernoulli variables of parameters $2^{-|w|(1-\unicode[STIX]{x1D702})}$ . We consider the (very sparse) remaining values $\widetilde{\unicode[STIX]{x1D707}}=\{\unicode[STIX]{x1D707}(I_{w}):w\in \unicode[STIX]{x1D6F4}^{\ast },p_{w}=1\}$ . We study the geometric and statistical information associated with $\widetilde{\unicode[STIX]{x1D707}}$ , and the relation between $\widetilde{\unicode[STIX]{x1D707}}$ and $\unicode[STIX]{x1D707}$ . To do so, we construct a random capacity $\mathsf{M}_{\unicode[STIX]{x1D707}}$ from $\widetilde{\unicode[STIX]{x1D707}}$ . This new object fulfills the multifractal formalism, and its free energy is closely related to that of $\unicode[STIX]{x1D707}$ . Moreover, the free energy of $\mathsf{M}_{\unicode[STIX]{x1D707}}$ generically exhibits one first order and one second order phase transition, while that of $\unicode[STIX]{x1D707}$ is analytic. The geometry of $\mathsf{M}_{\unicode[STIX]{x1D707}}$ is deeply related to the combination of approximation by dyadic numbers with geometric properties of Gibbs measures. The possibility to reconstruct $\unicode[STIX]{x1D707}$ from $\widetilde{\unicode[STIX]{x1D707}}$ by using the almost multiplicativity of $\unicode[STIX]{x1D707}$ and concatenation of words is discussed as well.
Janus V2AsP monolayer : a ferromagnetic semiconductor with a narrow band gap, a high Curie temperature and controllable magnetic anisotropy

The search and design of two-dimensional (2D) magnetic semiconductors for spintronics applications are particularly significant. In this work, we investigated the electronic and magnetic properties of Janus structure based on Dirac half-metallic vanadium phosphide (VP) monolayer (ML) by first-principles calculations. Due to the vertical symmetry breaking, Janus V2AsP ML becomes an intrinsic ferromagnetic semiconductor with a narrow band gap of 0.21 eV. We analyzed the electronic structure and origin of the in-plane easy axis in Janus V2AsP. The electron effective mass is anisotropic and only 0.129 m0 along the x-direction. The Curie temperature Tc and magnetic anisotropy energy (MAE) of Janus V2AsP reach 490 K and 178 µeV per V atom, respectively. A uniaxial tensile stain ɛ x of 5% can increase its band gap and MAE to 0.39 eV and 210.6 µeV per V atom while maintaining its Tc being above room temperature. Moreover, the direction of the easy axis can be changed between the in-plane x- and y-direction by a small uniaxial tensile strain ɛ x of 2%. Our study can motivate further research on the design the magnetic semiconductors in Janus structures based on 2D Dirac half-metals for spintronics applications.
Functional equations as an important analytic method in stochastic modelling and in combinatorics

Functional equations (FE) arise quite naturally in the analysis of stochastic systems of different kinds : queueing and telecommunication networks, random walks, enumeration of planar lattice walks, etc. Frequently, the object is to determine the probability generating function of some positive random vector in $Z\_n^+$. Although the situation n = 1 is more classical, we quote an interesting non local functional equation which appeared in modelling a divide and conquer protocol for a muti-access broadcast channel. As for n = 2, we outline the theory reducing these linear FEs to boundary value problems of Riemann-Hilbert-Carleman type, with closed form integral solutions. Typical queueing examples analyzed over the last 45 years are sketched. Furthermore, it is also sometimes possible to determine the nature of the functions (e.g., rational, algebraic, holonomic), as illustrated in a combinatorial context, where asymptotics are briefly tackled. For general situations (e.g., big jumps, or n $\ge$ 3), only prospective comments are made, because then no concrete theory exists.
Search for C ii emission on cosmological scales at redshift Z ∼ 2.6

We present a search for C II emission over cosmological scales at high redshifts. The CII line is a prime candidate to be a tracer of star formation over large-scale structure since it is one of the brightest emission lines from galaxies. Redshifted C II emission appears in the submillimeter regime, which means it could potentially be present in the higher frequency intensity data from the Planck satellite is used to measure the cosmic infrared background (CIB). We search for CII emission over redshifts z = 2−3.2 in the Planck 545 GHz intensity map by cross-correlating the three highest frequency Planck maps with spectroscopic quasars and CMASS galaxies from the Sloan Digital Sky Survey III, which we then use to jointly fit CII intensity, CIB parameters, and thermal Sunyaev–Zeldovich (SZ) emission. We report a measurement of an anomalous emission I_ν=6.6^(+5.0)_(−4.8)×10^4 Jy sr^(−1) at 95 per cent confidence, which could be explained by C II emission, favouring collisional excitation models of C II emission that tend to be more optimistic than models based on C II luminosity scaling relations from local measurements; however, a comparison of Bayesian information criteria reveals that this model and the CIB & SZ model are equally plausible. Thus, more sensitive measurements will be needed to confirm the existence of a large-scale CII emission at high redshifts. Finally, we forecast that intensity maps from Planck cross-correlated with quasars from the Dark Energy Spectroscopic Instrument would increase our sensitivity to CII emission by a factor of 5, while the proposed Primordial Inflation Explorer could increase the sensitivity further.
Stability analysis and control for switched stochastic delayed systems

This paper investigates almost sure exponential stability and feedback stabilization for switched time‐delay systems with nonlinear stochastic perturbations. The main contributions of this paper are threefold: (i) based on the non‐convolution type multiple Lyapunov functionals and the mathematical induction approach, a mean‐square exponential stability condition for nonlinear stochastic switched systems is first established, such that the obtained average dwell time does not rely on any given decay rate; (ii) by using the method developed in part (i) and the stochastic analysis techniques and limit methods in probability, an almost sure exponential stability criterion for switched delayed systems with nonlinear stochastic uncertainties is presented, and then a state feedback controller for the systems under consideration is designed; and (iii) when certain assumptions are made on the nonlinear stochastic perturbations, the results in this paper are further improved by relaxing some conditions. The effectiveness of the proposed method is demonstrated by three illustrative examples. Copyright © 2015 John Wiley & Sons, Ltd.
Vanishing of Symplectic Homology and Obstruction to Flexible Fillability

For any asymptotically dynamically convex contact manifold $Y$, we show that $SH_{\ast }(W)=0$ is a property independent of the choice of topologically simple (i.e., $c_1(W)=0$ and $\pi _{1}(Y)\rightarrow \pi _1(W)$ is injective) Liouville filling $W$. In particular, if $Y$ is the boundary of a flexible Weinstein domain, then any topologically simple Liouville filling $W$ has vanishing symplectic homology. As a consequence, we answer a question of Lazarev partially: a contact manifold $Y$ admitting flexible fillings determines the integral cohomology of all the topologically simple Liouville fillings of $Y$. The vanishing result provides an obstruction to flexible fillability. As an application, we show that all Brieskorn manifolds of dimension $\ge 5$ cannot be filled by flexible Weinstein manifolds.
DECOHERENCE FUNCTIONAL AND INHOMOGENEITIES IN THE EARLY UNIVERSE

We investigate the quantum to classical transition of small inhomogeneous fluctuations in the early Universe using the decoherence functional of Gell-Mann and Hartle. We study two types of coarse graining; one due to coarse graining the value of the scalar field and the other due to summing over an environment. We compare the results with a previous study using an environment and the off-diagonal rule proposed by Zurek. We show that the two methods give different results.
Constant Terms of Coleman Power Series And Euler Systems in Function Field

We calculate the constant term of Coleman power series and use it to prove an analogue of Iwasawa Main Conjecture in function fields of characteristic p>0 using Euler systems. This result is proved by a similar method of classical proof of Iwasawa Main Conjecture, go back to Kolyvagin and Rubin. We construct Euler systems from theta function of Drinfeld modules and establish finite-singular comparison equation even when p is not invertible the coefficients.
Resolving the Discrepancy of Distance to M60, a Giant Elliptical Galaxy in Virgo

There is a well-known discrepancy in the distance estimation of M60, a giant elliptical galaxy in Virgo; the planetary nebula luminosity function (PNLF) distance moduli for this galaxy are, on average, 0.4 mag smaller than the values based on the surface brightness fluctuation (SBF) in the literature. We present photometry of the resolved stars in an outer field of M60 based on deep F775W and F850LP images in the Hubble Space Telescope obtained as part of the Pure Parallel Program in the archive. Detected stars are mostly old red giants in the halo of M60. With this photometry, we determine a distance to M60 using the tip of the red giant branch (TRGB). A TRGB is detected at F850LP mag, in the luminosity function of the red giants. This value corresponds to F814W mag and mag, where QT is a color-corrected F814W magnitude. From this we derive a distance modulus, ( Mpc). This value is 0.3 mag larger than the PNLF distances and 0.1 mag smaller than the SBF distances in the previous studies, which indicates that the PNLF distances to M60 reported in the literature have larger uncertainties than the suggested values.
Ant-Agonizing Aging without Tradeoffs in Queens

Molecular basis of extreme longevity and active reproduction in queen ants. A queen ant lives long and reproduces actively, whereas worker ants are short-lived and sterile. Insulin upregulation in the brain of pseudoqueens, and very likely in queens, activates insulin/ insulin-like growth factor 1 (IGF-1) signaling (IIS)–mitogen-activated protein kinase (MAPK) in the fat body and ovary, leading to active reproduction. Insulin from the brain also promotes the secretion of imaginal morphogenesis protein-late 2 (Imp-L2) in the ovary, which inhibits IIS–AKT, consequently promoting longevity.
A Giant Metrewave Radio Telescope survey for associated H i 21 cm absorption in the Caltech–Jodrell flat-spectrum sample

We report a Giant Metrewave Radio Telescope (GMRT) survey for associated HI 21-cm absorption from 50 active galactic nuclei (AGNs), at $z \approx 0.04 - 3.01$, selected from the Caltech-Jodrell Bank Flat-spectrum (CJF) sample. Clean spectra were obtained towards 40 sources, yielding two new absorption detections, at $z = 0.229$ towards TXS 0003+380 and $z = 0.333$ towards TXS 1456+375, besides confirming an earlier detection, at $z = 1.277$ towards TXS 1543+480. There are 92 CJF sources, at $0.01 \lesssim z \lesssim 3.6$, with searches for associated HI 21-cm absorption, by far the largest uniformly-selected AGN sample with searches for such absorption. We find weak ($\approx 2\sigma$) evidence for a lower detection rate of HI 21-cm absorption at high redshifts, with detection rates of $28^{+10}_{-8}$\% and $7^{+6}_{-4}$\% in the low-$z$ ($z z_{\rm med}$) sub-samples, respectively. We use two-sample tests to find that the strength of the HI 21-cm absorption in the AGNs of our sample depends on both redshift and AGN luminosity, with a lower detection rate and weaker absorption at high redshifts and high ultraviolet/radio AGN luminosities. Unfortunately, the luminosity bias in our sample, with high-luminosity AGNs arising at high redshifts, implies that it is not currently possible to identify whether redshift evolution or AGN luminosity is the primary cause of the weaker absorption in high-$z$, high-luminosity AGNs. We find that the strength of HI 21-cm absorption does not depend on AGN colour, suggesting that dust extinction is not the main cause of reddening in the CJF sample.
Plasma and interstitial levels of endocannabinoids and N-acylethanolamines in patients with chronic widespread pain and fibromyalgia: a systematic review and meta-analysis

Supplemental Digital Content is Available in the Text. Increased levels of plasma oleoylethanolamide and stearoylethanolamide in patients with fibromyalgia and plasma palmitoylethanolamide and interstitial stearoylethanolamide in patients with chronic widespread pain suggest that the endocannabinoid system may be dysregulated in these conditions.
Left atrial appendage exclusion with less invasive left ventricular assist device implantation

The objective of this single‐center, pilot, prospective, and historical control study is to evaluate safety and feasibility outcomes associated with left atrial appendage exclusion (LAAE) concomitant with left ventricular assist device (LVAD) implantation via less invasive surgery (LIS) as a stroke prevention strategy.