Miracle-dz/UniFAR-FTUs huggingface dataset:
Morphological and Taxonomic Properties of the Newly Isolated <italic toggle='yes'>Cotonvirus japonicus</italic>, a New Lineage of the Subfamily <italic toggle='yes'>Megavirinae</italic>

Since 2003, various viruses from the subfamily Megavirinae in the family Mimiviridae have been isolated worldwide, including icosahedral mimiviruses and tailed tupanviruses. To date, the evolutionary relationship between tailed and nontailed mimiviruses has not been elucidated. Here, we present the genomic and morphological features of a newly isolated giant virus, Cotonvirus japonicus (cotonvirus), belonging to the family Mimiviridae. It contains a linear double-stranded DNA molecule of 1.47Mb, the largest among the reported viruses in the subfamily Megavirinae, excluding tupanviruses. Among its 1,306 predicted open reading frames, 1,149 (88.0%) were homologous to those of the family Mimiviridae. Several nucleocytoplasmic large DNA virus (NCLDV) core genes, aminoacyl-tRNA synthetase genes, and the host specificity of cotonvirus were highly similar to those of Mimiviridae lineages A, B, and C; however, lineage A was slightly closer to cotonvirus than the others were. Moreover, based on its genome size, the presence of two copies of 18S rRNA-like sequences, and the period of its infection cycle, cotonvirus is the most similar to the tupanviruses among the icosahedral mimiviruses. Interestingly, the cotonvirus utilizes Golgi apparatus-like vesicles for virion factory (VF) formation. Overall, we showed that cotonvirus is a novel lineage of the subfamily Megavirinae. Our findings support the diversity of icosahedral mimiviruses and provide mechanistic insights into the replication, VF formation, and evolution of the subfamily Megavirinae. IMPORTANCE We have isolated a new virus of an independent lineage belonging to the family Mimiviridae, subfamily Megavirinae, from the fresh water of a canal in Japan, named Cotonvirus. In a proteomic tree, this new nucleocytoplasmic large DNA virus (NCLDV) is phylogenetically placed at the root of three lineages of the subfamily Megavirinae—lineages A (mimivirus), B (moumouvirus), and C (megavirus). Multiple genomic and phenotypic features of cotonvirus are more similar to those of tupanviruses than to those of the A, B, or C lineages, and other genomic features, while the host specificity of cotonvirus is more similar to those of the latter than of the former. These results suggest that cotonvirus is a unique virus that has chimeric features of existing viruses of Megavirinae and uses Golgi apparatus-like vesicles of the host cells for virion factory (VF) formation. Thus, cotonvirus can provide novel insights into the evolution of mimiviruses and the underlying mechanisms of VF formation.
A Retrospective Study to Investigate the Clinical Performance and Safety of BMI CSF Shunting System in Patients Who Needed Cerebrospinal Fluid Drainage Therapy

Background: Despite BMI Cerebrospinal Fluid (CSF) Shunting System has been on the market for decades, no studies have been carried out. This retrospective study examined its clinical performance and safety, and attempted to discern risk factors. Methods: Medical records from 232 patients with External Ventricular Drainage (EVD) placement and 35 patients with Ventriculoperitoneal (VP) shunt placement were reviewed for 1 year and 2 years postoperatively, respectively. Results: The incidence of device malfunction was 22.9% for VP shunt in 2 years and 25.4% for EVD in 1 year. The most common cause of device malfunction was over drainage for VP shunt; and distal displacement and infection for EVD. The incidence of complications was 2.9% in the VP shunt group and 27.6% in the EVD group, while that of device-related infections were 0.0% and 7.3%, respectively. No one in the VP shunt died in 2 years postoperatively, while 2 patients (0.9%) in the EVD group died in 1 year postoperatively. No factors were found to influence the VP shunt survival; while age, catheter diameter, type of hydrocephalus, and Glasgow Coma Scale (GCS) score before surgery were found to have significant impact on EVD function. Conclusion: Compared to other similar device, BMI EVD showed comparable clinical performance and VP shunt showed superior clinical performance. Both devices were safe, with limited devicerelated infections reported. Our study sheds some light on the long-term outcome of BMI CSF Shunting System. Further study on a larger population is warranted to verify the predictors of device survival we identified in this analysis.
Is a Proactive Approach to Controlling Legionella in the Environment Justified?

SUMMARY Research background Legionella are Gram-negative bacteria that are ubiquitous in the natural environment. Contaminated water in man-made water systems is a potential source of transmission of legionnaires’ disease. The aim of this study is to explore the prevalence of Legionella pneumophila in the drinking water distribution system (DWDS) of Primorje-Gorski Kotar (PGK) County, Croatia, for the period 2013-2019, coupled with the incidence of legionnaires’ disease. A number of L. pneumophila-positive samples (>100 CFU/L), serogroup distribution and the degree of contamination of specific facilities (health and aged care, tourism, and sports) were assessed. Based on the obtained results, the reasoning for the implementation of a mandatory Legionella environmental surveillance program was assessed. Experimental approach Sample testing for Legionella was carried out according to the standard method for enumeration of this bacterium. A heterotrophic plate count (HPC) and Pseudomonas aeruginosa number were analysed along with the basic physicochemical indicators of drinking water quality. The research period was divided into two parts, namely, the 2013-2018 period (before implementation of the prevention program, after the outbreak of legionnaires’ disease), and the year 2019 (proactive approach, no disease cases recorded). Results and conclusion During the 7-year observation period in PGK County, an increase in the number of samples tested for Legionella was found. An increase in Legionella-positive samples (particularly pronounced during the warmer part of the year) was recorded, along with a growing trend in the number of reported legionnaires’ disease cases. In addition to hot water systems, the risk of Legionella colonisation also applies to cold water systems. Health and aged care facilities appear to be at highest risk. In addition to the higher proportion of positive samples and a higher degree of microbiological load in these facilities, the highest proportion of L. pneumophila SGs 2-14 was identified. Due to the diagnostic limitations of the applied tests, the number of legionnaires’ disease cases is underdiagnosed. Novelty and scientific contribution The introduction of a mandatory preventive approach to monitoring Legionella in DWDS water samples, along with the definition of national criteria for the interpretation of the results will create the preconditions for diagnosis and adequate treatment of larger numbers of legionnaires’ disease cases.
Diverse genetic characteristics of ESBL-producing Klebsiella pneumoniae isolates from obstetrics & gynaecology settings in some major hospitals, China

Background: We investigated the susceptibility patterns and genotype of extended-spectrum-beta-lactamase (ESBL)-producing Klebsiella pneumoniae isolates. Methods: A prospective survey of K. pneumoniae-infected patients was conducted in obstetrics & gynaecology settings in three associated hospitals of a university in China from 2017 to 2019. All isolates were identified as K. pneumoniae by the conventional standard procedures and confirmed by use of the VITEK GNI system. Susceptibility to 16 antimicrobial agents of ESBLs was determined by way of a screening procedure using discs. PCR amplification of bla genes, and sequencing of PCR products were performed to determine their molecular types. Results: A total of 518 of K. pneumoniae were isolated from sputum specimens in three affiliated hospitals. Out of these, 158 strains were ESBL producers and 64 strains were non-ESBL producers from the first hospital; 114 strains were positive for producing ESBLs and 60 strains were negative for ESBLs in the second hospital, and 86 strains were ESBL producer and 36 strains were negative from the third hospital. bla gene contents showed that 88 strains (24.6%) carried the blaTEM−2 gene, and 74 strains (20.1%) contained the blaSHV −3 gene, 44 strains (12.3%) had the blaCTX−M−2 gene, 42 strains (11.7%) had the blaCTX−M−4 gene, 38 strains (10.6%) harboured blaCTX−M−5 and blaCTX−M−8 genes, and 29 (9.5%) strains contained blaCTX−M−15 gene. Also, 20 (5.6%) strains contained blaOXA−1. The co-existence of blaCTX−M−15 and blaSHV −3 was identified in 20 strains (5.6%), 12 strains (3.3%) co-existed with blaSHV −3 and blaTEM−2, 14 isolates (3.9%) harboured blaTEM−2 and blaCTX−M−15, eight isolates (2.2%) possessed blaSHV −3, blaTEM−2, and blaCTX−M−15. Discussion: The high prevalence of ESBLs in K. pneumoniae isolates with diverse enzyme gene types indicated the need for screening the changes in ESBL-producing isolates in this region.
Reliability and agreement of three-dimensional/four-dimensional transperineal ultrasound in women with chronic pelvic pain

Background: Chronic pelvic pain is a common complaint in the gynecological o fice. The association among anus levator muscle injury, CPP of unknown origin in parous women, and pelvic sensory symptoms have been demonstrated. The study's purpose is to assess the intrarater/interrater reliability and agreement of pelvic loor biometry and levator ani muscle injury evaluated using threedimensional ultrasound in women with chronic pelvic pain. Methods: Two raters independently and blindly acquired three datasets of three-dimensional transperineal ultrasound volumes. The datasets were evaluated 60 days apart. To assess levator ani muscle injury, the hiatal area/diameter, levator ani muscle thickness, urethra-anus distance, and levator-urethra gap were measured. The intrarater reproducibility and interrater reproducibilitywere calculated. The concordance correlation coe ficients and limits of agreement were analyzed in 147 three-dimensional ultrasound volumes obtained from 49 patients. Results: Levator ani muscle injury was detected in 10.2% (n = 5/49), with a good intrarater concordance correlation of>0.90 for anteroposterior diameter, hiatal area, levator-urethra gap, and urethra-anus distance. The hiatal transverse diameter and levator animuscle thicknesspresentedpoor correlation,with limitsof agreement of 28.2% and 29.7%, respectively. The levator-urethra gap also presented poor interrater concordance. Overall, the interrater evaluation had moderate to substantial concordance. Discussion: In the detectionof levatoranimuscle injury inparouswomen, thehiatal anteroposterior diameter, hiatal area, andurethra-anusdistance canbe reliably assessed using three-dimensional transperineal ultrasound of the pelvic loor. However, owing to poor reliability, the hiatal transverse diameter, levator ani muscle thickness, and levator ani muscle-urethra gap require more studies before they can be applied clinically.
Antibiotic Susceptibility of Bacterial Isolates from Pus Specimens Collected from a General Hospital in Dhaka, Bangladesh

Abstract: Antibiotic resistance and its rapid spread among pathogenic bacterial isolates are regarded as major public health issues around the world. The study aims to detect pyogenic bacteria in pus samples and assess their antibiotic susceptibilities to various antibiotics commonly employed in chemotherapeutic interventions. This is a retrospective study in which 297 pus samples were obtained from patients in the year 2018 to 2020 for aerobic culture and sensitivity testing. In total, 32% (95) of the samples yielded positive results, whereas, 68% (202) yielded negative results. The most commonly occurring pathogen was E. coli (65) followed by Pseudomonas spp. (14), Staphylococcus aureus (9), Klebsiella spp. (4) and Acinetobacter spp. (3). Patients aged 51 and up were the ones who were largely afflicted by the pus infection. Males were shown to be more susceptible to infection than females. Amikacin, Ceftazidime, Meropenem, Cefotaxime, Netilmicin, Mecillinam, and Fosfomycin were the most susceptible drugs for Klebsiella spp. , followed by Meropenem for E. coli, Cloxacillin, Doxacillin, Cefotaxime, and Amoxiclave for S. aureus. However, Pefloxacin and Amoxiclav were both effective against Pseudomonas spp. , while Levofloxacin, Ciprofloxacin, Doxacillin, Tazobactam+Piperacillin, Imipenem, Netilmicin, and Trimethoprim were effective against Acinetobacter spp. The antibiotic, Ampicillin was found to be resistant to all of the microorganisms tested. In general, most of the isolates were found to be resistant to the majority of the antibiotics. As a result of our research, clinicians will be able to make better decisions when selecting appropriate antibiotics, which aid in patient care and judicious usage, preventing the development of drug resistance in those who are already susceptible.
DAIR: Data Augmented Invariant Regularization

While deep learning through empirical risk minimization (ERM) has succeeded at achieving humanlevel performance at a variety of complex tasks, ERM generalizes poorly to distribution shift. This is partly explained by overfitting to spurious features such as background in images or named entities in natural language. Synthetic data augmentation followed by empirical risk minimization (DA-ERM) is a simple yet powerful solution to remedy this problem. In this paper, we propose data augmented invariant regularization (DAIR). The idea of DAIR is based on the observation that the model performance (loss) is desired to be consistent on the augmented sample and the original one. DAIR introduces a regularizer on DA-ERM to penalize such loss inconsistency. Both theoretically and through empirical experiments, we show that a particular form of the DAIR regularizer consistently performs well in a variety of settings. We apply it to multiple real-world learning problems involving domain shift, namely robust regression, visual question answering, robust deep neural network training, and task-oriented dialog modeling. Our experiments show that DAIR consistently outperforms ERM and DA-ERM with little marginal cost and setting new state-of-the-art results in several benchmarks.
Corporate & Business Strategy Review

How to cite this paper: Dietz, B. , & zu Knyphausen-Aufseß, D. (2021). Reacquisitions vs. “regular” acquisitions and divestitures: A comparison of investor responses. Corporate & Business Strategy Review, 2(1), 54–68. https://doi.org/10.22495/cbsrv2i1art5 Copyright © 2021 The Authors This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). https://creativecommons.org/licenses/by/4
The Discrete Ordinates Characteristics Solution to the One-Dimensional Radiative Transfer Equation

ABSTRACT A simple quasi-analytical method is proposed to solve the boundary-value problem of radiative transfer through a participating planar layer with reflective/transparent boundary under diffuse/collimated incident radiation. The method couples angular discretization using quadrature sets such as in the discrete ordinates method, with the solution of the system of radiative characteristics variables of first-order differential equations that were obtained after eigenvalue decomposition of the matrix obtained from media radiative characteristics such as the extinction coefficient and the scattering phase function. Henceforth, the proposed method is designated as discrete ordinates characteristics solution, to emphasize on the two aspects. The predicted radiative fluxes, hemispherical transmittance and reflectance are shown to agree with benchmark literature results for various scattering phase functions, scattering albedo, optical thicknesses and boundary conditions.
OPTH_A_236423 375..385

1Department of Medicine Ophthalmology, University of Udine, Udine, Italy; 2Istituto Europeo di Microchirurgia Oculare (IEMO), Udine, Italy Purpose: This meta-analysis aims to summarize 12-month best-corrected visual acuity (BCVA) outcomes in response to anti-vascular endothelial growth factor (VEGF) therapy and dexamethasone implant for the treatment of diabetic macular edema (DME) and to identify factors affecting treatment response using evidence generated from metaregression. Methods: A systematic review of electronic databases was conducted to identify randomized controlled trials (RCTs) and real-life/observational studies that reported 12-month changes in BCVA in patients with DME on anti-VEGF or dexamethasone implant treatment in monotherapy. Study factors that were analyzed are baseline patient characteristics, study type, drug employed, number of injections and 12-month change in BCVA. Data were pooled in a random-effects meta-analysis with BCVA change as the main outcome. Meta-regression was conducted to assess the impact of multiple covariates. Results: One-hundred-five heterogeneous study populations (45,032 eyes) were identified and included in the analysis. The use of anti-VEGFs and dexamethasone implant induced an overall increase of +8.13 ETDRS letters in BCVA at 12 months of follow-up. Metaregression provided evidence that mean BCVA change using anti-VEGFs was not statistically higher for RCTs (p=0.35) compared to observational studies. Dexamethasone implant showed a trend for better results in observational studies over RCTs. Populations following a fixed aflibercept regimen performed better than those following a reactive treatment regimen. Mean BCVA gain was higher in younger populations (p<0.001), with lower baseline BCVA (p<0.0001) and longer diabetes duration (p<0.0001), receiving a higher number of injections (p<0.0001). Conclusion: Intravitreal therapy with anti-VEGFs or dexamethasone implant produces a significant improvement in BCVA at 12 months in patients with DME. Meta-regression identified the modifiable covariates that can be targeted in order to maximize functional results.
Preslaughter Anesthesia with Lippia alba Essential Oil Delays the Spoilage of Chilled Rhamdia quelen

ABSTRACT This study evaluated whether anesthesia with essential oil (EO) of Lippia alba (300 mg L−1 for 4 min) prior to electronarcosis (128 V m−1 × 300 Hz for 5 s) or hypothermia (ice/water slurry) could delay fish spoilage during chilled storage of whole fish. Silver catfish (Rhamdia quelen) were subjected to two different pre-stunning treatments (water or anesthesia with EO of L. alba) followed by two different stunning procedures (hypothermia or electrical stunning), yielding four groups (n = 32/group): water (control) + hypothermia, water (control) + electrical stunning, EO of L. alba + hypothermia, and EO of L. alba + electrical stunning. After stunning, fish were slaughtered by percussion and stored in ice. Preslaughter anesthesia with the EO of L. alba extended fish shelf life by delaying the loss of freshness (nucleotide degradation), growth of Enterobacteriaceae, and fish deterioration (sensory evaluation). Such preservative effect was most remarkable for fish that were subsequently submitted to electrical stunning, as they had the lowest demerit scores and greatest shelf life in the sensory evaluation. Our results showed that preslaughter anesthesia with EO of L. alba followed by electrical stunning can delay the loss of freshness and extend fish shelf life during chilled storage.
Use of Three-Column Classification System to Manage Tibial Plateau Fracture

Introduction: Complex tibia plateau fracture has been gradually increased, due to an increase in motor vehicle accidents. Clinical outcomes of tibia plateau fractures have been improved, due to the development of different concepts and techniques like staged surgery, combined approach, and fixation of posterior fragments. The purpose of this study was to evaluate clinical outcomes by using column-specific fixation techniques for tibia plateau fractures. Methods: From June 2014 to May 2016, 19 cases of tibia plateau fractures were operated on in our institution. Single column fracture was fixed with a Cannulated Cancellous Screw (CCS) or single plate, two-column fractures were treated with dual plate fixation and tri-columnar fracture was fixed with three plates. Results: The mean Rasmussen anatomic score was 16.11 (SD, 2.82; range 10 to 18). Anatomic outcome was excellent in 12 (63.3%), good in 5 (26.3%) and fair in 2 (10.5%) patients. The mean Rasmussen functional score was 26.05 (SD, 2.32; range 19 to 29). Functional outcome was excellent in 10 (52.6%), good in 8 (42.2%) and fair in 1 (5.2%) patients. Mean knee flexion at the end of treatment was 134 ̊ (SD, 8 ̊; 120 ̊ to 140 ̊), however, 3 patients had extension lag of 10 ̊. Conclusion: Managing tibial plateau fracture is a challenge to an orthopedic surgeon. The column-specific fixation techniques give good anatomical reduction to restore articular congruity, rigid fixation, facilitate early motion, and better functional outcomes.
The mediating role of socio-economy on the relationship between customer lifestyles and the awareness of MobiCash banking services of Wahda Bank in Libya

Article history: Received 13 November 2020 Accepted 5 January 2021 Published 31 January 2021 The 2013-2014 liquidity crisis in Libya has resulted in many Libyans' difficulties accessing their banking accounts and managing their financial standing. In place of this, many commercial banks have developed new mobile payment techniques, particularly the 'MobiCash' Service offered by Wahda Bank to assist Libyan customers in accessing their accounts and carrying out their financial transactions. This paper intends to examine the effect of lifestyle changes on mobile banking services or 'MobiCash' and their awareness of this novel service. Also, this study investigates the more profound understanding of Libyan customers. It highlights customers' socioeconomic characteristics using 'MobiCash' services offered by Wahda Bank in the city of Derna in Libya. The questionnaires were distributed online, and a sample of 149 was obtained. SPSS was used to analyse the data and regression analysis to test the significant effect of customers' lifestyles and their awareness of 'MobiCash'. The results showed that Libyan customers were accepting of this form of mobile banking. The findings indicated that age and academic degrees do not influence awareness of 'MobiCash'. However, customer lifestyles affect awareness of the banking service of 'MobiCash'. Socio-Economic factors do not mediate the relationship between lifestyle and awareness of banking services of 'MobiCash'. This study's outcomes have increased the current knowledge on the behaviours and awareness of novel banking service features like 'MobiCash'. Moreover, the study may provide a more in-depth understanding of what is needed for Libyan banking customers to accept further this technological service and, thus, permit the improvement of banking strategies to attract potential users. Future researchers can extend the understanding of this study in other contexts and service environment.
Does CEO power influence corporate risk and performance? Evidence from Greece and Hungary

How to cite this paper: Fayyaz, U. -E-R. , Jalal, R. N. -U. -D. , Antonucci, G. , & Venditti, M. (2021). Does CEO power influence corporate risk and performance? Evidence from Greece and Hungary. Corporate Ownership & Control, 18(4), 77–89. https://doi.org/10.22495/cocv18i4art6 Copyright © 2021 The Authors This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). https://creativecommons.org/licenses/by