Miracle-dz/UniFAR-FTUs huggingface dataset:
Slowly Making Sense: A Review of the Two-Step Venom System within Slow (Nycticebus spp.) and Pygmy Lorises (Xanthonycticebus spp.)

Since the early 2000s, studies of the evolution of venom within animals have rapidly expanded, offering new revelations on the origins and development of venom within various species. The venomous mammals represent excellent opportunities to study venom evolution due to the varying functional usages, the unusual distribution of venom across unrelated mammals and the diverse variety of delivery systems. A group of mammals that excellently represents a combination of these traits are the slow (Nycticebus spp.) and pygmy lorises (Xanthonycticebus spp.) of south-east Asia, which possess the only confirmed two-step venom system. These taxa also present one of the most intriguing mixes of toxic symptoms (cytotoxicity and immunotoxicity) and functional usages (intraspecific competition and ectoparasitic defence) seen in extant animals. We still lack many pieces of the puzzle in understanding how this venom system works, why it evolved what is involved in the venom system and what triggers the toxic components to work. Here, we review available data building upon a decade of research on this topic, focusing especially on why and how this venom system may have evolved. We discuss that research now suggests that venom in slow lorises has a sophisticated set of multiple uses in both intraspecific competition and the potential to disrupt the immune system of targets; we suggest that an exudate diet reveals several toxic plants consumed by slow and pygmy lorises that could be sequestered into their venom and which may help heal venomous bite wounds; we provide the most up-to-date visual model of the brachial gland exudate secretion protein (BGEsp); and we discuss research on a complement component 1r (C1R) protein in saliva that may solve the mystery of what activates the toxicity of slow and pygmy loris venom. We conclude that the slow and pygmy lorises possess amongst the most complex venom system in extant animals, and while we have still a lot more to understand about their venom system, we are close to a breakthrough, particularly with current technological advances.
Fatty Acid Composition of a Maternal Diet and Erythrocyte Phospholipid Status in Latvian Pregnant Women

Background and Objectives: Dietary fats are essential for maternal and fetal health. Fatty acids (FAs) in erythrocytes characterize the FA profile, which is influenced by diet and other factors. The aim of this study was to evaluate the association between the main FAs in erythrocyte membrane phospholipids and their influencing factors—dietary fat and supplement intake and lifestyle factors—in Latvian pregnant women. Materials and Methods: This cross-sectional study included 236 pregnant and postpartum women. The data were collected from medical documentation, a food frequency questionnaire, and a questionnaire on demographic, lifestyle, health status, and nutritional habits in outpatient clinics and maternity departments. FAs in erythrocyte membrane phospholipids were determined using gas chromatography. Results: Correlations were found between dietary SFAs and erythrocyte SFAs (r = −0.140, p = 0.032) and PUFAs (r = 0.167, p = 0.01) and between dietary PUFAs and erythrocyte MUFAs (r = −0.143, p = 0.028). Dietary SFAs, MUFAs, and PUFAs positively correlated with the studied n-3 and n-6 FAs in erythrocytes. Vitamin D correlated positively with MUFA and negatively with total PUFA and AA in erythrocytes. There was a negative correlation between dietary vitamin A and linoleic acid in erythrocytes. Physical activity negatively correlated with erythrocyte MUFAs and positively with erythrocyte PUFAs. Alcohol consumption positively correlated with erythrocyte SFAs and negatively with erythrocyte PUFAs. Conclusions: There are indications that some dietary FAs may be correlated with erythrocyte FAs. Possible influencing factors for this association are alcohol, physical activity, vitamin D, and vitamin A.
Recent Advances in Microbiota-Associated Metabolites in Heart Failure

Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased in the literature on the role of specific gut microbiota metabolites in heart failure development, this review highlights and summarizes the current evidence and underlying mechanisms associated with the pathogenesis of heart failure. We found that gut microbiota-derived metabolites such as short chain fatty acids, bile acids, branched-chain amino acids, tryptophan and indole derivatives as well as trimethylamine-derived metabolite, trimethylamine N-oxide, play critical roles in promoting heart failure through various mechanisms. Mainly, they modulate complex signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells, Bcl-2 interacting protein 3, NLR Family Pyrin Domain Containing inflammasome, and Protein kinase RNA-like endoplasmic reticulum kinase. We have also highlighted the beneficial role of other gut metabolites in heart failure and other cardiovascular and metabolic diseases.
Differential impact of 5-lipoxygenase-activating protein antagonists on the biosynthesis of leukotrienes and of specialized pro-resolving mediators

Lipoxygenases (LOX) transform arachidonic acid (AA, C20:4) and docosahexaenoic acid (DHA, C22:6) into bioactive lipid mediators (LMs) that comprise not only pro-inflammatory leukotrienes (LTs) but also the specialized pro-resolving mediators (SPMs) that promote inflammation resolution and tissue regeneration. The 5-LOX-activating protein (FLAP) is known to provide AA as a substrate to 5-LOX for generating LTs, such as LTB4, a potent chemoattractant and activator of phagocytes. Notably, 5-LOX is also involved in the biosynthesis of certain SPMs, namely, lipoxins and D-resolvins, implying a role of FLAP in SPM formation. FLAP antagonists have been intensively developed as LT biosynthesis inhibitors, but how they impact SPM formation is a matter of debate. Here, we show that FLAP antagonism suppresses the conversion of AA by 5-LOX to LT and lipoxins, while the conversion of DHA to SPM is unaffected. Screening of multiple prominent FLAP antagonists for their effects on LM formation in human M1- and M2-monocyte-derived macrophages by comprehensive LM profiling showed that all nine compounds reduced the production of 5-LOX-derived LTs but increased the formation of SPMs from DHA, e.g., resolvin D5. Some FLAP antagonists, especially those that contain an indole or benzimidazole moiety, even elicited SPM formation in resting M2-monocyte-derived macrophages. Intriguingly, in coincubations of human neutrophils and platelets that produce substantial AA-derived lipoxin and DHA-derived RvD5, FLAP antagonism abolished lipoxin formation, but resolvin D5 levels remained unaffected. Conclusively, antagonism of FLAP suppresses the conversion of AA by 5-LOX to LTs and lipoxins but not the conversion of DHA by 5-LOX to SPM, which should be taken into account for the development of such compounds as anti-inflammatory drugs.
Survival outcomes of patients with oligometastatic non-small cell lung cancer who were treated with radical therapy: a multicenter analysis

Background/aim Oligometastatic disease for nonsmall cell lung cancer (NSCLC) patients is generally thought to represent a better prognosis with a quieter biology, limited number of disease sites and long-term disease control. In this study, we aimed to determine the efficacy of radical treatment options for patients with oligometastatic NSCLC. Materials and methods This retrospective trial included totally 134 patients with oligometastatic NSCLC. The presence of oncodriver mutation, tumor stages and nodal status, the number of metastases and involved metastatic site, treatment of primary tumor and oligometastasis, response rate, overall survival (OS) and progression-free survival (PFS) were evaluated. Results Of 134 patients 66.4% were defined as adenocarcinoma, 26.1% were squamous cell carcinoma and 7.5% of patients were in other histology. Based on the treatment of primary tumor, in 36 patients (26.9%) curative surgery has undergone, in addition, 19 (14.2%) patients were received chemotherapy, 73 (54.5%) were treated with chemoradiotherapy, while immunotherapy and targeted therapy were used in 1 (0.7%) and 2 (1.4%), respectively. The preferred treatment for oligometastatic lesions were SBRT in 72.4% of patients, surgery in 10.5%, and both SBRT and surgery in 17.1% of patients. At the median follow up of 31.3 months (range: 9.5–48.5), the median PFS and OS times were 17 and 24.4 months, respectively. Moreover, OS-2 after progression was also 7.2 months. Conclusion Based on our real-life experience, we demonstrated a significant correlation between good response to first treatment and survival in oligometastatic disease, we also understand that local ablative treatment modalities prolong and also delay both OS and PFS in oligometastatic NSCLC patients OS-2.
Share price behavior of Nepalese insurance companies

This research explores the influencing factors of market share price behavior in the Nepalese insurance business. The study focuses on four insurance firms and utilizes a purposive sample approach, yielding a dataset of 40 observations. The research investigates the correlations between significant factors such as dividend payout ratio (DPR), Earnings per share (EPS), price–earnings ratio (PER), dividend per share (DPS), and market price per share (MPS). The data show strong relationships between these characteristics and the MPS. The DPR and MPS have a negative connection, indicating that increased dividend distributions may lead to lower market prices. Positive correlations, on the other hand, are discovered among EPS, PER, DPR, and MPS, indicating that investors appreciate firms with greater profitability, growth prospects, and dividend payments. The research adds to the knowledge of share price behavior in Nepalese insurance firms. However, it is crucial to note that the findings are based on small sample size and may not apply to other sectors or countries. To fully understand the factors determining market pricing, future research should investigate increasing the sample size and including longitudinal approaches. These results have practical ramifications for investors, insurers, and politicians. Understanding share price behavior allows stakeholders to make educated choices about investment strategies, financial performance assessment, and policy creation to improve economic performance and shareholder value in Nepal's insurance business.
The role of strategic alignment between innovative culture and generic strategy in restaurant sectors: Empirical evidence from Vietnam

Abstract This paper draws upon the contingency theory and generic strategy framework to examine the impact of innovative culture and the strategic alignment between this culture and cost-leadership and differentiation strategy on restaurant performance of small restaurants in Vietnam. Data were collected by sending out an online survey to 175 small restaurants in Vietnam. Partial least-squared structural equation modeling was used to examine data. The results indicate that innovative culture enhances restaurant performance. Besides, the alignment between innovative culture and differentiation strategy induces restaurant performance, while the alignment between this culture and cost-leadership strategy does not. In this regard, this study addresses the role of strategic alignment in restaurant settings and contributes to the theoretical development of the contingency theory. In addition, this study also provides some practical implications for managers of small restaurants in Vietnam.
The core bacteriobiome of Côte d’Ivoire soils across three vegetation zones

The growing understanding that soil bacteria play a critical role in ecosystem servicing has led to a number of large-scale biogeographical surveys of soil microbial diversity. However, most of such studies have focused on northern hemisphere regions and little is known of either the detailed structure or function of soil microbiomes of sub-Saharan African countries. In this paper, we report the use of high-throughput amplicon sequencing analyses to investigate the biogeography of soil bacteria in soils of Côte d’Ivoire. 45 surface soil samples were collected from Côte d’Ivoire, representing all major biomes, and bacterial community composition was assessed by targeting the V4-V5 hypervariable region of the 16S ribosomal RNA gene. Causative relationships of both soil physicochemical properties and climatic data on bacterial community structure were infered. 48 phyla, 92 classes, 152 orders, 356 families, and 1,234 genera of bacteria were identified. The core bacteriobiome consisted of 10 genera ranked in the following order of total abundance: Gp6, Gaiella, Spartobacteria_genera_incertae_sedis, WPS-1_genera_incertae_sedis, Gp4, Rhodoplanes, Pseudorhodoplanes, Bradyrhizobium, Subdivision3_genera_incertae_sedis, and Gp3. Some of these genera, including Gp4 and WPS-1_genera_incertae_sedis, were unequally distributed between forest and savannah areas while other taxa (Bradyrhizobium and Rhodoplanes) were consistently found in all biomes. The distribution of the core genera, together with the 10 major phyla, was influenced by several environmental factors, including latitude, pH, Al and K. The main pattern of distribution that was observed for the core bacteriobiome was the vegetation-independent distribution scheme. In terms of predicted functions, all core bacterial taxa were involved in assimilatory sulfate reduction, while atmospheric dinitrogen (N2) reduction was only associated with the genus Bradyrhizobium. This work, which is one of the first such study to be undertaken at this scale in Côte d’Ivoire, provides insights into the distribution of bacterial taxa in Côte d’Ivoire soils, and the findings may serve as biological indicator for land management in Côte d’Ivoire.
The Role of Hybrid-Working in Improving Employees' Satisfaction, Perceived Productivity, and Organizations' Capabilities

Objective: This study aims to identify the factors influencing employees' satisfaction and productivity in hybrid-working, such as reconciliation between professional and personal lives, flow experience, work flexibility, and organizational support. It also aims to analyze the effect of employees' satisfaction and perceived productivity on workers' intention to continue working hybrid in the future. Design/Methods/Approach: Data was gathered through an online questionnaire sent to potential participants. A total of 433 eligible respondents were collected for analysis. This study utilized Structural Equation Modelling (SEM) to examine the connections between reconciliation, flow experience, flexibility, organizational support, employee satisfaction, perceived productivity, and workers' intention to continue with hybrid work. Findings: Consistent with the hypotheses, reconciliation, flow experience, flexibility, and organizational support are positively and significantly associated with employee satisfaction and perceived productivity while working from home. Employee satisfaction and perceived productivity also positively and significantly influence workers' intention to continue with hybrid-work. Originality: This study combines motivating factors and factors that focus on the relationship between employees and organizations to develop the antecedents affecting satisfaction and productivity during work-from-home. The findings of this study contradict the previous research regarding the influence of productivity on workers' intention to continue with hybrid work. Both satisfaction and perceived productivity significantly affect workers' intention to work hybrid in the future. This implies that employees feel higher satisfaction and productivity when working from home, hence the inclination to continue this particular working method. Practical/Policy implication: Given the results, top management and HR professionals should consider, at the earliest possible, to start implementing hybrid-work in the organizations. The findings imply that employees intend to continue with hybrid-work because they feel higher satisfaction and perceived productivity while working from home. Also, organizations can observe what factors can improve employee satisfaction and perceived productivity while working hybrid and utilize that information to provide a better working environment for employees and organizations.
TAKSACIONI ELEMENTI SASTOJINA JELE, SMRČE I BUKVE PRAŠUMSKOG TIPA U BOSNI

Prirodni odnosi pojedinih vrsta drveća i osnovne karakteristike njihovih tafcsacionih elemenata najbolje se mogu upoznati, u sastojinama gdje još nije bilo nikakve intervencije čovjeka. Takve objekte predstavljaju naše prašume. Ispitivanje pojava u odnosima zastupljenih vrsta kod ovih prašumskih tipova od značaja je za izbor postupka u okviru gospodarenja sa prebornim šumama. Ovo zbog toga što je sastav naših prebornih šuma u mnogome sličan onom kod sastojina prašumskih tipova.Potreba ovih ispitivanja nameće se tim prije što sastojine prašumskih tipova sve više iščezavaju. S obzirom na drvnu masu, šume obuhvaćene ovim rezervatima sastavljene su od jele i smrče sa malim učešćem bukve. Nadmorske visine variraju cca od 1.000 do 1.700 m. Prema izloženom, ova ispitivanja se -odnose na prašumske tipove viših položaja u kojima pretežno učestvuju Jela i smrča.
Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission

The careful monitoring of patients with mild/moderate COVID-19 is of particular importance because of the rapid progression of complications associated with COVID-19. For prognostic reasons and for the economic management of health care resources, additional biomarkers need to be identified, and their monitoring can conceivably be performed in the early stages of the disease. In this retrospective cross-sectional study, we found that serum concentrations of high-mobility group box 1 (HMGB1) and heme oxygenase-1 (HO-1), at the time of hospital admission, could be useful biomarkers for COVID-19 management. The study included 160 randomly selected recovered patients with mild to moderate COVID-19 on admission. Compared with healthy controls, serum HMGB1 and HO-1 levels increased by 487.6 pg/mL versus 43.1 pg/mL and 1497.7 pg/mL versus 756.1 pg/mL, respectively. Serum HO-1 correlated significantly with serum HMGB1, oxidative stress parameters (malondialdehyde (MDA), the phosphatidylcholine/lysophosphatidylcholine ratio (PC/LPC), the ratio of reduced and oxidative glutathione (GSH/GSSG)), and anti-inflammatory acute phase proteins (ferritin, haptoglobin). Increased heme catabolism/hemolysis were not detected. We hypothesize that the increase in HO-1 in the early phase of COVID-19 disease is likely to have a survival benefit by providing protection against oxidative stress and inflammation, whereas the level of HMGB1 increase reflects the activity of the innate immune system and represents levels within which the disease can be kept under control.
Monthly changes of collembolan population under the gradients of moisture, organic carbon and nitrogen contents in a sub-tropical forest soil, Manipur.

Population study of collembola for one calendar year was made in relation with moisture, organic carbon and nitrogen contents of a sub-tropical forest floor upto 0-10 cm. soil layer. Soil moisture content played important role and developed a significant correlation (p>0.01) with the monthly population density of collembola. With increase carbon and nitrogen contents also observe increase population density indicating collembola’s active participation in the release of these two nutrients from litter through decomposition and its incorporation in soil fertility.
A Comparative Study of Serum Sodium and Potassium Levels across the Three Trimesters of Pregnancy

Aim: To evaluate the serum sodium and potassium levels in the three trimesters of pregnancy in women. Methods: Four groups of healthy women between the ages of 20 and 30 years, volunteered for this study. Group 1: Non-pregnant women (control), Group 2: Pregnant women in their first trimester, Group 3: Pregnant women in their second trimester, Group 4: Pregnant women in their third trimester. Blood samples were collected by standard aseptic method and serum samples were analyzed for serum levels of sodium and potassium by the ion selective electrode method. Results were presented as MEAN ± SEM in tables and figures, p < 0.05 was regarded as statistically significant. Results: The serum sodium concentrations in mmol/L were 135.3 ± 3.09, 136.3 ± 1.55, 139.0 ± 0.78, 139.8 ± 0.91 for control, first-trimester, second-trimester, and third-trimester subjects respectively. The potassium concentrations in mmol/L were 3.678 ± 0.26, 3.687 ± 0.13, 3.820 ± 0.11, 3.767 ± 0.07 for control, first-trimester, second trimester and third-trimester subjects respectively. The Bodyweight values in kg were 72.13 ± 2.11, 74.73 ± 2.05, 75.00 ± 1.72, 81.56 ± 4.24 for control, first-trimest, second-trimester, and third-trimester subjects respectively. Conclusion: Results indicate that the hormones of pregnancy altered the body weight of pregnant women, but did not change the serum sodium and potassium level across the three trimesters of pregnancy in women. This is an indication that the kidneys of healthy pregnant women can handle serum electrolyte load during the period of pregnancy.
Elevated Soil Copper Content in a Bohemian Vineyard as a Result of Fungicide Application

A set of fifty samples were taken from soil surface layers of an anonymous vineyard in the Bohemia region of the Czech Republic. Samples were analysed for basic soil parameters including pH and humus content and quality and for potentially toxic elements Cu, Pb, Zn, Cd and Mn. When compared to soil guideline values, mean Cu exceeded the limit by 280%. Although other elements did not exceed the guideline value, Zn and Cd surpassed background concen - trations by 108 and 187%, respectively. Mn did not occur in concentrations that are considered excessive with respect to common natural soil levels. A statistically significant correlation was observed for Cu and C ox , but no significant correlation could be made between Cu and humus quality, suggesting that in this case, Cu retention in surface soil is more dependent on quantity of humic substances rather than humus quality. The unnaturally high accumulation of Cu in the surface horizon is certainly of anthropogenic origin; most likely due to long term application of copper-based fungicides. High observed values of Cd are probably a result of the soils parent material and application of fertilizers which may have contained cadmium compounds. Distribution maps illustrated a common trend of potentially toxic element accumulation in the western section of the study area plot. However, many variables which were unmeasured in this study could account for the distribution and therefore more detailed study is required before conclusions can be made regarding this occurrence. An analysis of wine produced at the vineyard showed that although the end product beverage contained insignificant amounts of Cu in both red and white wines, the white wine contained 0.026 mg/l of Cd; a value which could contribute considerably to exceeding the dietary allowable intake of cadmium. The investigation should be extended to analyse a wider range of wines produced from the vineyard with a focus on soil-plant-fruit-wine transfer of cadmium and/or production processes.