Miracle-dz/UniFAR-FTUs huggingface dataset:
Modélisation des bi-grappes et sélection des variables pour des données de grandedimension : application aux données d’expression génétique

Clustering is a classical method to analyse gene expression data. When applied to the rows (e.g. genes), each column belongs to all clusters. However, it is often observed that the genes of a subset of genes are co-regulated and co-expressed in a subset of conditions, but behave almost independently under other conditions. For these reasons, biclustering techniques have been proposed to look for sub-matrices of a data matrix. Biclustering is a simultaneous clustering of rows and columns of a data matrix. Most of the biclustering algorithms proposed in the literature have no statistical foundation. It is interesting to pay attention to the underlying models of these algorithms and develop statistical models to obtain significant biclusters. In this thesis, we review some biclustering algorithms that seem to be most popular. We group these algorithms in accordance to the type of homogeneity in the bicluster and the type of overlapping that may be encountered. We shed light on statistical models that can justify these algorithms. It turns out that some techniques can be justified in a Bayesian framework. We develop an extension of the biclustering plaid model in a Bayesian framework and we propose a measure of complexity for biclustering. The deviance information criterion (DIC) is used to select the number of biclusters. Studies on gene expression data and simulated data give satisfactory results. To our knowledge, the biclustering algorithms assume that genes and experimental conditions are independent entities. These algorithms do not incorporate prior biological information that could be available on genes and conditions. We introduce a new Bayesian plaid model for gene expression data which integrates biological knowledge and takes into account the pairwise interactions between genes and between conditions via a Gibbs field. Dependence between these entities is made from relational graphs, one for genes and another for conditions. The graph of the genes and conditions is constructed by the k-nearest neighbors and allows to define a priori distribution of labels as auto-logistic models. The similarities of genes are calculated using gene ontology (GO). To estimate the parameters, we adopt a hybrid procedure that mixes MCMC with a variant of the Wang-Landau algorithm. Experiments on simulated and real data show
Impact of Low-Head Dam Removal on River Morphology and Habitat Suitability in Mountainous Rivers

Dam removal is considered an effective measure to solve the adverse ecological effects caused by dam construction and has started to be considered in China. The sediment migration and habitat restoration of river ecosystems after dam removal have been extensively studied abroad but are still in the exploratory stage in China. However, there are few studies on the ecological response of fishes at different growth stages. Considering the different habitat preferences of Schizothorax prenanti (S. prenanti) in the spawning and juvenile periods, this study coupled field survey data and a two-dimensional hydrodynamic model to explore the changes in river morphology at different scales and the impact of changes in hydrodynamic conditions on fish habitat suitability in the short term. The results show that after the dam is removed, in the upstream of the dam, the riverbed is eroded and cut down and the riverbed material coarsens. With the increase in flow velocity and the decrease in flow area, the weighted usable area (WUA) in the spawning and juvenile periods decreases by 5.52% and 16.36%, respectively. In the downstream of the dam, the riverbed is markedly silted and the bottom material becomes fine. With the increase in water depth and flow velocity, the WUA increases by 79.91% in the spawning period and decreases by 67.90% in the juvenile period, which is conducive to adult fish spawning but not to juvenile fish growth. The changes in physical habitat structure over a short time period caused by dam removal have different effects on different fish development periods, which are not all positive. The restoration of stream continuity increases adult fish spawning potential while limiting juvenile growth. Thus, although fish can spawn successfully, self-recruitment of fish stocks can still be affected if juvenile fish do not grow successfully. This study provides a research basis for habitat assessment after dam removal and a new perspective for the subsequent adaptive management strategy of the project.
Development and Validation of New Exercises to Promote Physical Activity in Nursing Home Settings

Background: GAMotion is a giant physical activity board game intended to improve levels of physical activity and a broader array of physical and psychological outcomes among nursing home residents. Objective: The aim of the present study is to develop and validate new balance, flexibility, muscle strength, and walking exercises to be included in GAMotion. Methods: A two-step design combining the Focus group and Delphi method was conducted among healthcare professionals divided into two independent samples of experts. The first sample was asked to develop exercises during a focus group. The second sample participated in a two-round Ranking-type Delphi method. During the first round, the participants were asked to rate the exercises developed during the focus group on a four-point Likert scale (from 1: not adapted at all to 4: very adapted). The exercises that did not reach consensus were removed (consensus established: median ≥ 3 on the Likert scale and at least 75% of experts rating the exercises as « adapted » or « very adapted »). During the second round, it was asked to rank the exercises selected at the end of the first round from most suitable to least suitable. Results: The Focus group developed nine balance, twelve flexibility, twelve strength, and nine walking exercises. Following the first round of the Delphi method, two exercises in each category did not reach a consensus and were then removed. In the second round, the remaining seven balance, ten flexibility, ten strength, and seven walking exercises were ranked by the experts, and this classification allowed us to determine the four most suitable exercises from each category to be included in the GAMotion. Conclusion: A consensus-based approach among healthcare professionals allowed us to contribute to the development of new exercises to promote physical activity in nursing homes. These validated exercises can be included in the GAMotion board game.
A Comparative Study between the Three Waves of the Pandemic on the Prevalence of Oropharyngeal Dysphagia and Malnutrition among Hospitalized Patients with COVID-19

Background: The phenotype of patients affected by COVID-19 disease changed between the waves of the pandemic. We assessed the prevalence of oropharyngeal dysphagia (OD), malnutrition (MN), and mortality between the first three waves of COVID-19 patients in a general hospital. Methods: a prospective observational study between April 2020–May 2021. Clinical assessment for OD was made with the volume-viscosity swallowing test; nutritional assessment was performed consistent with GLIM criteria. A multimodal intervention was implemented in the second and third wave, including (a) texturized diets—fork mashable (1900 kcal + 90 g protein) or pureed (1700 kcal + 75 g protein), (b) oral nutritional supplements (500–600 kcal + 25–30 g protein), and (c) fluid thickening (250 mPa·s or 800 mPa·s). Results: We included 205 patients (69.3 ± 17.6 years) in the 1st, 200 (66.4 ± 17.5 years) in the 2nd, and 200 (72.0 ± 16.3 years;) in the 3rd wave (p = 0.004). On admission, prevalence of OD was 51.7%, 31.3% and 35.1%, and MN, 45.9%, 36.8% and 34.7%, respectively; mortality was 10.7%, 13.6% and 19.1%. OD was independently associated with age, delirium, and MN; MN, with age, OD, diarrhea and ICU admission; mortality, with age, OD and MN. (4) Conclusions: Prevalence of OD, MN and mortality was very high among COVID-19 patients. OD was independently associated with MN and mortality. An early and proactive multimodal nutritional intervention improved patients’ nutritional status.
Joint Effect of Heavy Vehicles and Diminished Light Conditions on Paediatric Pedestrian Injuries in Backover Crashes: A UK Population-Based Study

Backover crashes cause considerable injuries especially among young children. Prior research on backover crashes has not assessed the joint effect of heavy vehicles and diminished light conditions on injuries. By analysing the United Kingdom STATS19 crash dataset from 1991 to 2020, this study focused on backover crashes involving paediatric cyclists or pedestrians aged ≤17 years and other motorised vehicles. By estimating the adjusted odds ratio (AOR) of multiple logistic regression models, pedestrians appeared to have 82.3% (95% CI: 1.78–1.85) higher risks of sustaining killed or serious injuries (KSIs) than cyclists. In addition, casualties involved in backover crashes with heavy vehicles were 39.3% (95% CI: 1.35–1.42) more likely to sustain KSIs than those involved in crashes with personal cars. The joint effect of heavy vehicles and diminished light conditions was associated with a 71% increased probability of sustaining KSIs (AOR = 1.71; 95% CI: 1.60–1.83). Other significant joint effects included young children (aged 0 to 5 years) as pedestrian (AOR = 1.92; 95% CI: 1.87–1.97), in diminished light conditions (AOR = 1.23; 95% CI: 1.15–1.31), and with heavy vehicle (AOR = 1.37; 95% CI: 1.28–1.47).
Nonlinear H2/H∞ Constrained Feedback Control: A Practical Design Approach Using Neural Networks

Preliminaries and Introduction. - Policy Iterations and Nonlinear H 2 Constrained State Feedback Control. - Nearly H 2 Optimal Neural Network Control for Constrained-Input Systems. - Policy Iterations and Nonlinear H ? Constrained State Feedback Control. - Nearly H ? Optimal Neural Network Control for Constrained-Input Systems. - Taylor Series Approach to Solving HJI Equation. - An Algorithm to Solve Discrete HJI Equations Arising from Discrete Nonlinear H ? Control Problems. - H ? Static Output Feedback.
Risk factors for cesarean section in women of urban Puducherry, India: A matched case–control study

Cesarean section (CS) is generally performed either to ensure maternal and child safety when vaginal delivery is not possible. The WHO has indicated that CS rates of more than 10% are considered overutilization. Increased CS rates can cause an increase in postpartum antibiotic treatment and longer hospital stay. In this research, we conducted a matched case–control study, including all women who gave birth through CS and resided in the study area over a 3-year period before the survey as cases and similar age- and year-matched women who had normal vaginal delivery during the same period as controls. The data were collected using a semi-structured pro forma through personal interviews and verified with discharge cards. We obtained a sample of 140 women (70 matched cases and controls) as study participants. Our results show that unadjusted analysis revealed socioeconomic status, history of gestational diabetes mellitus, previous lower segment CS (LSCS), and malpresentation emerged as risk factors, whereas in the adjusted analysis, we observed that previous LSCS (aOR 45.4 [4.3 – 483.6]), malpresentation (aOR 11.0 [1.6 – 73.8]), and belonging to middle (aOR 3.3 [1.0 – 10.8]) and upper class (aOR 23.55 [CI: 1.2 – 463.8]) remained as independent risk factors. Our study identified independent risk factors for CS that needs to be tackled for bringing down the CS rates.
LncRNA H19 Promotes Lung Adenocarcinoma Progression via Binding to Mutant p53 R175H

Simple Summary This research explored the association and interaction between lncRNA H19 and mutant p53 (R175H) in lung adenocarcinoma development and progression. H19 over-expression may induce the elevated expression of mtp53 and interact with mtp53, which prolongs the p53 half-life and promotes transcriptional activity, leading to the progression of lung adenocarcinoma. The simultaneous inhibition of H19 and mtp53 may provide a novel strategy. Abstract Background: Accumulating data suggest that long non-coding RNA (lncRNA) H19 and p53are closely related to the prognosis of lung cancer. This study aims to analyze the association and interaction betweenH19 and mutant p53 R175H in lung adenocarcinoma (LAC). Methods: Mutant-type (Mt) p53 R175H was assessed by using RT-PCR in LAC cells and 100 cases of LAC tissue samples for association with H19 expression. Western blot, RNA-pull down, immunoprecipitation-Western blot and animal experiments were used to evaluate the interaction between H19 and mtp53. Results: Mtp53 R175H and H19 were over-expressed in LAC tissues and cells, while H19 over-expression extended the p53 half-life and enhanced transcriptional activity. Combined with anti-p53, ShH19 can significantly inhibit tumor growth in vivo. Conclusions: H19 over-expression may induce the elevated expression of mtp53 and interact with mtp53, leading to LAC progression. In addition, the high expression of mtp53 R175H is associated with poor overall survival inpatients. The simultaneous inhibition of H19 and mtp53 may provide a novel strategy for the effective control of LAC clinically.
Study of Many Biochemical and Oxidative Stress Variables in Patients with Atherosclerosis in Kirkuk City

The current study was designed to detect the role of a number of chemical variables represented by fasting blood sugar, hemoglobin A1c and insulin and oxidative stress factors in atherosclerosis patients. The present study involved (70) blood samples aged between (35-65) years the first group involved (40) blood samples from atherosclerosis patients and the second group involved (30) blood samples from healthy individuals, the samples were collected from respondents at Kirkuk General Hospital and Azadi Teaching Hospital in Kirkuk for a while 2021/12/22 to 2022/2/8 and the samples were taken after eight hours of fasting and all the information was taken from the reviewers by means of a questionnaire that included age, body mass index, systolic pressure and diastolic pressure and the results were as follows: significant increase in body mass index in the group of atherosclerosis patients compared to a healthy control group at a significant level (p 0.05) and 55% of them had elevated systolic pressure rate and 40% of them had high diastolic pressure ,the results from the current study show a significant increase in the concentration of asprosin compared to the control group at a significant level (p 0.05),the results of cardiac troponin(t) show a significant increase in the concentration of troponin in the patients of atherosclerosis compared to the control group at a significant level (p 0.05). The results of the study biochemical variables have shown significant increase in fasting blood sugar in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05) and the results of glycated hemoglobin Test (A1c) showed a significant increase in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05) and the results of insulin showed a significant increase in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05). While the results of the study of the oxidative stress which included the glutathione and malondialdehyde there was insignificant reduction in serum concentration of GSH in atherosclerosis patients at a significant level (p 0.05) compared to a control group, and it has also been noted that was a significant increase in serum concentration of MDA in the atherosclerosis patients compared to a control group at a significant level (p 0.05).
Hypoactive Libido: Neurohumoral Characteristics, Regions of the Brain Regulating Sexual Desire, and Its Reactions to Erotic Stimuli

The article indicates that sexual desire is considered to result from a complex balance between inhibitory and stimulating factors (neurotransmitters, hormones), which influence functioning of the brain. For example, dopamine, oxytocin, estrogens, noradrenalin, melanocortin, norepinephrine and testosterone produce excitory influence, while serotonin, endocannabinoiids, prolactin (PRL) and opioids produce inhibitory influence. The article contains data of researches, which informed about peculiarities in reactions of the brain in people with hypoactive sexual desire to erotic stimuli as well as sex differences of the above reactions to these stimuli. Also, key regions in the brain that regulate sexual desire (the prefrontal cortex, locus coeruleus, medial preoptic area, paraventricular nucleus, and reward- and attention-processing centers of the ventral tegmental area and the nucleus accumbens) are listed. Information about hormonal regulation of sexual desire in men is given. The article informs about studies that are not consistent with the established view about an inhibitory influence of hyperprolactinaemia (HP) on sexual functions in men (G. Corona et al., 2007, 2014), whose authors, on the contrary, note that analysis of the relation between PRL level and sexual disorders revealed a strong correlation between lower PRL levels and reduced pleasure from orgasm. They also revealed that a low PRL level was associated with erectile dysfunction (ED) and early ejaculation. This phenomenon may be explained by the fact that the low PRL level was associated with bad health. G. Corona et al. (2007, 2014) insist that severe HP may be associated with ED only because of HP, which in its turn is caused by hypogonadal state. Moreover, and what is especially important for the problem in question, severe HP was associated with hypoactive sexual desire (HSD), an increased level of thyrotropin and hypogonadism. A relationship between severe HP and HSD was confirmed after correction of testosterone and thyrotropic hormone levels and use of psychotropic agents. The cited authors conclude that in compliance with their findings severe, rather than mild, HP is an important determinant of HSD. Nevertheless they believe that PRL can produce more positive than negative effects in initiating and maintaining sexual behavior. Our article also discusses hormonal regulation of sexual desire in women. Though before it was supposed that adrenal androgens played a pivotal role for appearance of sexual desire in them, later an opinion formed that it was not so and the focus was shifted to ovarian corticosteroids, including estradiol and testosterone. It is noted that though ovarian corticosteroids can produce some effect on sexual desire in women, their exact role in the appearance of HSD disorder in females remains unclear.
A PLS-SEM Analysis to Check Public Willingness to Use Water from Filtration Plants Installed by Public Own Organizations; a Study of Psychological Behavior Toward Sustainable Development

Introduction Water is the basic need of human beings and there is no substitute for water. This research was conducted to analyze public willingness to use water from filtration plants installed by public own Organizations and which psychological factors may help them to decide to use safe water. Methods There ought to be some nudges in the right direction to encourage people to use water filters. A questionnaire was adopted from the literature for this research. PLS-SEM is used to evaluate data to check the connection among variables since it is the most recommended way for assessing and predicting explained variables to account for the largest latent variance, and PLS-SEM is one of the most effective approaches for predicting outcomes. Results PLS-SEM direct path analysis revealed that hypotheses H1-H6 were accepted and the gender and levels of education of the respondents as control variables, gender and education showed insignificant relationships with WUFWFP. Age showed a substantial relationship as a moderator variable between WQK*Age, and HC*Age with a willingness to use filter water from filtration plants=WUFWFP, while the rest of the variables showed an insignificant relationship. Discussion As per our results, H1a and H3a have a significant relationship as moderator variables between IV and DV, while H2a, H4a, H5a, and H6a did not show any relationship as moderator variables between IV and DV. Hence H1a and H3a were accepted while the rest of the moderator was rejected under this research. This study would be helpful for the decision-makers and planners to take proper sustainable measures to address the repercussions of urbanization and land use changes to protect the ecosystem.
Introduction to the Statistical Physics of Integrable Many-body Systems

Including topics not traditionally covered in literature, such as (1+1)-dimensional QFT and classical 2D Coulomb gases, this book considers a wide range of models and demonstrates a number of situations to which they can be applied. Beginning with a treatise of nonrelativistic 1D continuum Fermi and Bose quantum gases of identical spinless particles, the book describes the quantum inverse scattering method and the analysis of the related Yang–Baxter equation and integrable quantum Heisenberg models. It also discusses systems within condensed matter physics, the complete solution of the sine-Gordon model and modern trends in the thermodynamic Bethe ansatz. Each chapter concludes with problems and solutions to help consolidate the reader's understanding of the theory and its applications. Basic knowledge of quantum mechanics and equilibrium statistical physics is assumed, making this book suitable for graduate students and researchers in statistical physics, quantum mechanics and mathematical and theoretical physics.
Is that Insta worthy? Predicting content sharing behavior on social media through interpersonal goals

What motivates people to share contents that promote the image of the self versus the well-being of others on social media? Two studies examined how interpersonal goals, namely self-image goals and compassionate goals, influence intentions of sharing different contents on Instagram. According to research on interpersonal goals, self-image goals motivate people to maintain and demonstrate their desirable qualities to others; compassionate goals energize people to promote the well-being of others. Based on this research, we hypothesized that self-image goals (vs. compassionate goals) would propel people to have higher intentions to share contents that are self-promoting relatively more than contents that are prosocial. A correlational study that measured participants’ chronic (i.e., stable) interpersonal goals (Study 1; n = 126) and an experiment that manipulated participants’ incidental (i.e., momentary) interpersonal goals (Study 2; n = 201) confirmed these hypotheses. These results highlight the role of motivation in content sharing on social media and shed light on psychological mechanisms that help shape the social environment on Instagram.