Miracle-dz/UniFAR-FTUs huggingface dataset:
The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis

Background: As an antioxidant, vitamin E (VitE) may benefit the erythrocytes by protecting glutathione from oxidation by free radicals and peroxide-generating processes. Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines when reporting this systematic review. We searched 6 electronic databases (PubMed, Scopus, Web of Science, and Cochrane Library) until May 8, 2022. We included all relevant studies. According to the study design, the Cochrane assessment tool (Risk of Bias 2), Risk Of Bias In Non-randomized Studies - of Interventions checklists, and National Institutes of Health tools were used to assess the risk of bias. Continuous data were pooled as a mean difference (MD) with a relative 95% confidence interval. The protocol was registered on PROSPERO (CRD42022333848). Results: Six studies were included in the meta-analysis with a total of 181 patients. Compared with the control group, VitE significantly improved the hemoglobin level for chronic hemolysis (MD = 2.72 g/dL, P < .0001) and for acute hemolysis (MD = 1.18 g/dL, P < .0001). It also decreased the reticulocyte level for chronic hemolysis (MD = −1.39 P < .0001) and for acute hemolysis (MD = −1.42%, P < .0001). For before and after studies, the use of VitE significantly improved the level of packed cell volume (MD = 0.56%, P < .00001), red blood cell half-life (MD = 2.19 days, P < .0001), and decreased the reticulocytes level (MD = −1.41%, P < .00001). Conclusion: Among patients with glucose-6-phosphate dehydrogenase deficiency, VitE might provide benefits such as increasing the hemoglobin, packed cell volume levels, red blood cell half-life, and decreasing the reticulocyte level, so reducing hemolysis. Further high-quality, well-designed randomized controlled trials are recommended.
Efficacy and safety of pregabalin in eye pain: A systematic review

Background: The pregabalin is approved for the management of persistent pain. The aim of this study is to assess the advantages and disadvantages of the use of pregabalin in eye pain management. Methods: The PubMed, Cochrane Library, Embase, and Web of Science databases were searched until January 2022 for randomized controlled trials. Randomized, double-blinded trials comparing pregabalin with placebo in eye pain management were included. The primary outcome was visual analog scale or numerical rating scale at acute (24 hours) and chronic (≥7 days after surgery) timepoints. The secondary outcomes were analgesic medication requirements and pregabalin-related complications (nausea, vomiting, dizziness, and headache). We also compared the effect of pregabalin on dry-eye syndrome. Main results: Six relevant articles were identified that studied the use of pregabalin as pain relief for photorefractive keratectomy (n = 2), laser epithelial keratomileusis (n = 1), laser-assisted in situ keratomileusis (n = 1), eyelid surgery (n = 1), and dacryocystorhinostomy (n = 1). Pregabalin was associated with a significant reduction in pain scores (95% confidence interval = −0.41 [−0.76–−0.06]) 24 hours after surgical procedures. The data were insufficient to draw conclusions regarding dry eye symptoms. Because of the high heterogeneity of outcomes regarding adverse effects, there is no conclusion regarding the safety of pregabalin in eye pain. Conclusions: Pregabalin reduced acute eye pain but had no significant effect on long-term analgesia after ophthalmological surgery in adults. It had no effect on dry-eye symptoms after ocular surgery. Further studies on the safety of pregabalin in eye pain management are required to draw solid conclusions.
Temperature dependence of the magnetostriction of stress annealed Galfenol measured under tension

Galfenol (Fe100−xGax) is a relatively new, highly magnetostrictive active material with strains of about 330 ppm as a slow cooled single crystal and about 280 ppm as a highly textured polycrystal at x=∼18.4. Four main advantages over other materials are (1) Galfenol’s structural strength; (2) the ability of a single composition to operate over the temperature range of −269–+150 °C (for stress annealed rods, higher for unannealed rods); (3) the ability of stress annealed Galfenol to provide full performance under stresses ranging from at least −160 to +30 MPa (compressive stresses are negative); and (4) the ability to use standard metal working techniques. The magnetostriction and magnetization of two stress annealed, highly textured Fe81.6Ga18.4 rods were measured at temperatures between −50 and +100 °C and tensile stresses of approximately +1, +10, +20, +30, and +40 MPa. Measurements were taken inside an environmental chamber using a spring to supply the stress. A stress change of about 2 MPa between −50.
Autonomous Guidance for Rendezvous Phasing Based on Special-Point-Based Maneuvers

An improved method based on special-point-based maneuvers is presented to realize autonomous rendezvous phasing in a near-circular orbit. The phasing segment is divided into three subphases (the initial subphase, the natural phasing subphase, and the adjusting subphase) according to the relationship between orbital phase angle and semimajor axis difference between the chaser and the target. Maneuver to natural phasing orbit is done in the initial subphase. In the natural phasing subphase, the phase angle between two spacecraft is reduced naturally due to the semimajor axis difference, and then the maneuver to the adjusting orbit is implemented. In the adjusting subphase, the phase angle is reduced step by step to satisfy the close rendezvous approaches requirement. In addition to the in-plane maneuvers, the coplanar orbital corrections to eliminate the crosstrack difference are done in the corresponding subphase. All orbital maneuvers are given as guidance impulses and calculated onboard autonomously. Pre.
Liquid‐based cytology for differentiating two cases of pemphigus vulgaris from oral squamous cell carcinoma

Pemphigus vulgaris (PV) is a rare autoimmune disease characterized by blisters on the skin and mucous membrane. Since it often appears in the oral mucosa first, it may be diagnosed by oral mucosal cytology. Although the cytologic finding is characterized by acantholytic cells, that is, Tzanck cells, it is important to distinguish PV from neoplastic lesions of the oral mucosal epithelium, including differentiation from atypical parabasal/basal cells, which appear in squamous cell carcinoma (SCC). In this study, we examined the cellular findings in two cases of PV and a case of well‐differentiated SCC with loss of epithelial cell cohesion. The samples were prepared using liquid‐based cytology, which showed small round‐shaped and deeply stained atypical, orangeophilic keratinocytes not only in SCC but also in PV, which made differentiation between the two difficult. However, Tzanck cells found in PV differ from the deep atypical parabasal/basal cells of SCC, suggesting that the cell outline is indistinct and small protrusions and brush‐like structures are observed. This feature of Tzanck cells may be useful in cytological judgment.
Symmetric Multivariate and Related Distributions

Part 1 Preliminaries: construction of symmetric multivariate distributions notation of algebraic entities and characteristics of random quantities the "d" operator groups and invariance dirichlet distribution problems 1. Part 2 Spherically and elliptically symmetric distributions: introduction and definition marginal distributions, moments and density marginal distributions moments density the relationship between (phi) and f conditional distributions properties of elliptically symmetric distributions mixtures of normal distributions robust statistics and regression model robust statistics regression model log-elliptical and additive logistic elliptical distributions multivariate log-elliptical distribution additive logistic elliptical distributions complex elliptically symmetric distributions. Part 3 Some subclasses of elliptical distributions: multiuniform distribution the characteristic function moments marginal distribution conditional distributions uniform distribution in the unit sphere discussion symmetric Kotz type distributions definition distribution of R(2) moments multivariate normal distributions the c.f. of Kotz type distributions symmetric multivariate Pearson type VII distributions definition marginal densities conditional distributions moments conditional distributions moments some examples extended Tn family relationships between Ln and Tn families of distributions order statistics mixtures of exponential distributions independence, robustness and characterizations problems V. Part 6 Multivariate Liouville distributions: definitions and properties examples marginal distributions conditional distribution characterizations scale-invariant statistics survival functions inequalities and applications.
Efficacy of extracorporeal plasma therapy for adult native kidney patients with Primary FSGS: a Systematic review

Abstract Purpose This study aimed to assess efficacy of extracorporeal plasma therapy (EPT), including plasmapheresis (PE), immunoadsorption (IA), low-density lipoprotein apheresis (LDL-A), and lymphocytapheresis (LCAP) for adult native kidney patients with primary focal segmental glomerulosclerosis (FSGS). Methods A literature search was conducted using MEDLINE, EMBASE and Cochrane Databases through August 2022. Studies that reported outcomes of EPT in adult native kidneys with primary FSGS were enrolled. Results 18 studies with 104 therapy-resistant or refractory primary native FSGS patients were identified. Overall EPT response rate was 56%, with long-term benefit of 46%. Of the 101 non-hemodialysis (HD) patients, 54% achieved remission, with 30% complete remission (CR) and 23% partial remission (PR). Of 31 patients with PE, response rate was 65%; CR and PR rates were 27% and 37% in 30 non-HD patients. Of 61 patients with LDL-A, the response rate was 54%; CR and PR rates were 41% and 3% in 29 non-HD patients. Of 10 patients with IA, response rate was 40%. Of 2 patients with LCAP, 1 achieved CR, and one developed renal failure. All 3 HD patients showed increase in urine output and gradual decrease in urine protein excretion following PE (n = 1) or LDL-A (n = 2). 2 of 3 HD patients ultimately discontinued dialysis. Conclusion EPT with immunosuppressive therapy showed benefit in some patients with refractory primary FSGS, and PE appeared to have a higher response rate.
On the Length Scales of Turbulence for Aeroacoustic Applications

Accurate evaluation of the turbulence integral correlation length scales is important for a large group of numerical flow-induced noise prediction methods. Due to the complex mathematical interrelationships of the two-point space-time velocity statistics, a direct evaluation of the integral length scale is a challenging task from the standard CFD methods. The present paper focuses on the theoretical and experimental investigations of five different integral length scales evaluation methodologies, namely i) two-point space correlation based method, ii) single point power-spectrum based approach, iii) wavenumber of the most energy containing eddy dependent method, iv) auto correlation via Taylor’s hypothesis and, v) correlation function curve fitting method. All these methods are analyzed based on the previously performed two-point turbulent boundary-layer (BL) correlation measurement data. A detail comparison study has been performed with discussions on the limitations and drawbacks of each method. Other length scales found in turbulence theory such as pseudo length scale, dissipation length scale, Prandtl mixing length, Taylor microscale and Kolmogorov scale have been also discussed elaborately. A theoretical relationship for the derivation of integral length scales based on standard RANS simulation is derived by employing Kolmogorov local isotropy hypothesis. The enhanced method allows modelling of the isotropic length scale and dissipation from the anisotropic experimental spectral data. This outcome is applied further for the RANS turbulence model validation purpose in the framework of a turbulent boundary-layer trailingedge interaction (TBL-TE) noise prediction model. Results are extensively validated with the wind tunnel measurement of high Reynolds number airfoil BL flows.
Investigation on the I-V characteristics of a high concentration, photovoltaic array

The aim of this study was to highlight the effects on the I-V characteristics of concentrator arrays due to mismatch between series-connected high concentration PV modules and between single junction cells within a module. The mismatch between cells was caused by a number of factors including: misalignment of optical elements and cells, uneven shading due to dust or delamination of the cell-secondary lens interface, degradation of the main Fresnel lens and non-uniform cell material parameters. Small amounts of mismatch that would go unnoticed at one-Sun insolation levels are vastly amplified at high concentration ratios. This paper reports on, and interprets the regular I-V measurements that were recorded over a period of two years under various conditions. The effect of bypass diodes on the module I-V curves is also investigated. The general characteristics of the measured resultant I-V curves are explained. The degradation of the PV concentrator modules over a period of two years is also confirmed from the I-V measurements.
Turbulent structures in accelerating boundary layers

The vortical structures in spatially developing turbulent boundary layers subjected to streamwise acceleration are studied. Two cases are examined: one in which the acceleration is insufficient to cause reversion to the laminar state of the initially turbulent flow, and another in which the acceleration is stronger and relaminarization begins to take place; the pressure gradient, however, is not maintained long enough for full reversion to occur. The turbulent statistics show the expected trends: the mean velocity profile deviates significantly from the logarithmic law-of-the-wall and shows, in the strongly accelerated case, a tendency to approach the laminar profile; the turbulent kinetic energy increases less rapidly than the energy of the mean flow. The structure of the inner layer is also significantly altered. In the near-wall region, the streaks become more elongated and show fewer undulations, owing to a significant decrease of the spanwise fluctuations relative to the streamwise ones. The coherent.
LCN2-Fungal siderophore-iron binding and uptake leads to oxidative stress and cell death in hepatocellular carcinoma cell line HepG2

Abstract Microorganisms produce non-ribosomal peptides called siderophores for the purpose of iron acquisition. Mammalian immune system is well-known for producing small secretory proteins called lipocalins upon bacterial infection. These proteins sequester siderophores produced by invading bacterial pathogens rendering them unable to acquire iron from the host. However, this is not their sole function. In addition to transferrin and lactoferrin, lipocalins are also known to transport siderophore-bound iron to the host cells. While binding of bacterial siderophores with human lipocalin is well studied, binding of the fungal counterpart is still not confirmed and fully understood. Apart from pathogen-affected cells, developing cancerous cells also show varying expression level of different proteins including those involved in iron transport. The possibility of exogenous fungal siderophore-mediated iron transport via lipocalin and its receptor in mammalian cells has not yet been explored much. In present investigation we have checked differential expression of human lipocalin, LCN2 in hepatocellular carcinoma cell lines HepG2 as well as its normal counterpart WRL-68 and computationally determined the feasibility of LCN2 binding with fungal siderophore. Further in case of a stable complex being formed, whether this complex has the ability to transport iron through its specific receptor was assessed. Also, we have tried to explore possible mechanism of fungal-siderophore mediated oxidative stress leading to significant cell death in cancerous cells. This study will thus be useful towards finding a new way of treating hepatocellular carcinoma via inducing siderophore-mediated cell death in cancerous cells. Communicated by Ramaswamy H. Sarma
A Study of Abundances of Four Giants in the Low-Mass Globular Cluster Palomar 5

The low-mass globular cluster Pal 5 is found to contain a population of red giants that exhibits chemical abundance inhomogeneities similar to those seen in more massive globular clusters of comparable overall metallicity, such as M5. Previous observations had shown that CN and CH inhomogeneities exist among the brighter giants in this cluster. High-resolution spectra have been obtained of four giants of known CN-band strength in Pal 5 using the HIRES instrument on the Keck I telescope. The data have been analyzed to derive the abundances of the elements Fe, O, Na, Al, Si, Ca, Sc, Ti, V, Mn, Ni, Ba, La, and Eu. The [Fe/H] abundance is found to be -1.3 dex, similar to that of the globular cluster M5 ([Fe/H] = -1.2.) Among the proton-capture elements Na and Al, the Pal 5 stars show a very significant range of 0.6 dex in [Na/Fe], with a mean [Na/Fe] of +0.08, very similar to that of M5. The mean Al abundance of the Pal 5 sample is 0.2 dex lower than the mean for M5, and the Pal 5 giants show less spread in [Al/Fe] (∼0.4 dex) than the M5 giants, although, with only four giants, our Pal 5 sample is unlikely to reflect the extremes in the Al abundance distribution of the cluster. The CN-band strengths of Pal 5 giants show correlations with [Na/Fe] and [Al/Fe], and an anticorrelation with [O/Fe]. Such abundance relations suggest that material has been brought to the surface of some Pal 5 giants in which Na and Al has been synthesised and oxygen depleted by proton-addition reactions. Within the observational uncertainties the Fe-peak and neutron-capture elements have similar [X/Fe] ratios as M5 giants and field subdwarfs. In the case of the α-capture elements the observed Pal 5 giants have [α/Fe] lower by 0.12 dex than field subdwarfs and M5 giants. This measured difference is only a 2 σ result, however, and, given the smallness of our Pal 5 sample, it warrants confirmation by further observations. In terms of its element abundance ratios and abundance inhomogeneities Pal 5 appears to be quite typical of other higher mass globular clusters. Whatever process causes abundance inhomogeneities in globular clusters appears not to be sensitive either to the current mass of these objects or to disruptive processes, such as tidal shocking, that can lead to the loss of a significant fraction of the initial stellar content of a cluster.
Constant domain polymorphisms influence monoclonal antibody stability and dynamics

The constant regions of clinical monoclonal antibodies are derived from a select number of allotypes found in IgG subclasses. Despite a long‐term acknowledgment that this diversity may impact both antibody function and developability, there is a lack of data on the stability of variants carrying these mutations. Here, we generated a panel of IgG1, IgG2, and IgG3 antibodies with 32 unique constant region alleles and performed a systematic comparison of stability using red edge excitation shift (REES). This technique exploits the fluorescent properties of tryptophan residues to measure antibody structural dynamics which predict flexibility and the propensity to unfold. Our REES measurements revealed broad stability differences between subclasses with IgG3 possessing the poorest overall stability. Further interrogation of differences between variants within each subclass enabled the high‐resolution profiling of individual allotype stabilities. Crucially, these observed differences were not found to be linked to N297‐linked glycan heterogeneity. Our work demonstrates diverse stabilities (and dynamics) for a range of naturally occurring constant domain alleles and the utility of REES as a method for rapid and sensitive antibody stability profiling, requiring only laboratory spectrophotometry equipment.
ULF geomagnetic pulsations at different latitudes in Antarctica

Abstract. We present a study aimed to characterize the ULF (1–100 mHz) geomagnetic pulsation activity in the polar cap at different latitudes. We used magnetic measurements obtained through 2005–2007 in Antarctica, at Dome C (89° S corrected geomagnetic latitude) and at Terra Nova Bay (80° S corrected geomagnetic latitude). The results indicate a solar wind control of the wave activity, more important at larger distances from the cusp, as well as a significant role of the local ionospheric conditions. The different position of the two stations, with respect to the cusp and closed field lines, is responsible for the observed different pulsation characteristics. At Terra Nova Bay, due to the approaching of the station to the cusp and closed field lines in the daytime, the ULF power is characterized by a maximum around noon; daytime pulsation events in the Pc5 frequency band are related to the fundamental field line resonances occurring at lower latitudes, while higher harmonics of the fundamental may account for the characteristics of Pc3–4 pulsations. In the nighttime, at Pc3 frequencies, the results suggest waves propagating sunward, possibly due to the transmission of upstream waves from the magnetosheath via the magnetotail lobes. At Dome C, near the geomagnetic pole and very far from closed field lines, the ULF power in any frequency band only shows an enhancement in the postmidnight sector, more pronounced for Pc3 pulsations. The ULF activity appears to be driven by processes occurring in the magnetotail: in particular, nighttime Pc3 pulsation events may be originated from upstream wave penetration through the magnetotail lobes.
An optimised protocol for the investigation of insulin signalling in a human cell culture model of adipogenesis

ABSTRACT While there is no standardized protocol for the differentiation of human adipocytes in culture, common themes exist in the use of supra-physiological glucose and hormone concentrations, and an absence of exogenous fatty acids. These factors can have detrimental effects on some aspects of adipogenesis and adipocyte function. Here, we present methods for modifying the adipogenic differentiation protocol to overcome impaired glucose uptake and insulin signalling in human adipose-derived stem cell lines derived from the stromal vascular fraction of abdominal and gluteal subcutaneous adipose tissue. By reducing the length of exposure to adipogenic hormones, in combination with a physiological glucose concentration (5 mM), and the provision of exogenous fatty acids (reflecting typical dietary fatty acids), we were able to restore early insulin signalling events and glucose uptake, which were impaired by extended use of hormones and a high glucose concentration, respectively. Furthermore, the addition of exogenous fatty acids greatly increased the storage of triglycerides and removed the artificial demand to synthesize all fatty acids by de novo lipogenesis. Thus, modifying the adipogenic cocktail can enhance functional aspects of human adipocytes in vitro and is an important variable to consider prior to in vitro investigations into adipocyte biology.
Nascent function concepts in Nova Scientia

The origin of the function concept is usually traced to Galileo's work on motion. We argue that specific proto-function concepts appeared in the work of Tartaglia a century before the publication of Galileo's Two New Sciences. The study of Tartaglia's ideas can be used in the classroom as a historical introduction to various function concepts, and certain modern extensions of Tartaglia's optimal range problem and inverse range problem are sources of enrichment for undergraduate courses in analysis, mathematical modeling and computation.