Miracle-dz/UniFAR-FTUs huggingface dataset:
CMAR_A_275569 11813..11821

*These authors contributed equally to this work Background: Few studies have evaluated the outcomes of transhiatal and right thoracoabdominal resection of Siewert type II adenocarcinoma of the esophagogastric junction. This study investigated the relative effect of these two methods in the surgical treatment of Siewert type II adenocarcinoma of the esophagogastric junction. Methods: Clinical data for 211 Siewert type II cancer patients were collected and classified into transhiatal group (n = 181) and right thoracoabdominal group (n = 30) according to surgical approach. Short-term outcomes were compared between these two groups. A 1:1 propensity score matching was performed using a logistic regression model. Recurrence-free survival and overall survival were compared between the matched groups. Results: The right thoracoabdominal group had significantly greater intraoperative blood loss and longer operative time compared with transhiatal group. Complications corresponding to Clavien–Dindo grade III or higher were 4.4% in transhiatal group and 30% in right thoracoabdominal group (P < 0.05). The right thoracoabdominal group exhibited greater blood loss, longer operative time, longer hospitalization, and a smaller number of lymph nodes retrieved than the transhiatal group as evidenced by PSM analysis, and patients in transhiatal group also experienced significantly better survival than patients in right thoracoabdominal group. Conclusion: In this study, the transhiatal approach was associated with more favorable shortterm and oncological outcomes than the right thoracoabdominal group approach for Siewert type II adenocarcinoma of the esophagogastric junction. The transhiatal approach with total gastrectomy appears to be an optional choice for this type of tumor, especially for esophagus invasion ≤2 cm. Well-designed randomized control trials are necessary to validate our findings.
Environmental Knowledge of Participants’ Outdoor and Indoor Physical Education Lessons as an Example of Implementing Sustainable Development Strategies

: (1) Background: The purpose of the study was to assess the impact of physical activity outdoors in nature as part of physical education in schools on the level of knowledge and ecological attitudes. (2) Material and methods: A total of 220 students took part in the study, with 103 of them in the treatment group, which usually practiced outdoor physical education classes, and 117 in the control group, which practiced mainly indoor. The project lasted 21 months, covering the last two years of primary school. The authors used the Children’s Environmental Attitude and Knowledge Scale CHEAKS in this study. The authors sought for an answer to the question of whether bringing a young person closer to nature by participating in a greater number of outdoor physical education lessons results in in-depth environmental knowledge. (3) Results: The appearance of seven statistically signiﬁcant differences in ecological knowledge in the ﬁnal study in favor of the group having outdoor physical education lessons proves the cognitively and visually stimulating role of a natural environment for physically active people. The location of physical education lessons turned out to be a much stronger condition for in-depth knowledge than gender, place of residence, parents’ education level, and subjective assessment of the ﬁnancial satisfaction level. (4) Conclusion: These results are an incentive to further developing the young generation’s contact with nature through outdoor physical education lessons.
Patellar Tendon Loading During Dynamic Landings: How this is Moderated by Fatigue and the Presence of a Patellar Tendon Abnormality

When investigating lower limb landing biomechanics, researchers often assume movement symmetry for the simplicity of data collection and analysis, despite the fact that landing tasks often involve dual-limb motion. As it is unknown whether lower limb symmetry can be assumed when investigating dynamic, sport-specific movements such as the stop-jump, this study aimed to investigate whether there were any significant between-limb differences in selected kinetic, kinematic and muscle activation patterns characterising lower limb biomechanics of the landing phases of a stop-jump task. Sixteen male athletes with normal patellar tendons on diagnostic imaging performed five successful stop-jump trials. Patellar tendon forces, ground reaction forces, threedimensional kinematics, and electromyographic activity of seven lower limb muscles were recorded for the dominant and non-dominant lower limb during each trial. Most biomechanical variables did not significantly vary as a function of lower limb dominance, implying relative lower limb symmetry throughout the landing phases of the stop-jump task. However, during the horizontal landing phase, the dominant lower limb
INDIVIDUAL PREFERENCES IN SECURITY RISK DECISION MAKING: AN EXPLORATORY STUDY UNDER SECURITY PROFESSIONALS

Risk assessments in the (cyber) security domain are often, if not always, based on subjective expert judgement. For the first time, to the best of our knowledge, the individual preferences of professionals from the security domain are studied. In on online survey they are asked to mention, rate and rank their preferences when assessing a security risk. The survey setup allows to differentiate between easily accessible or “on top of mind” attributes and guided or stimulated attributes. The security professionals are also challenged to both non-compensatory and compensatory decision making on the relevance of the attributes. The results of this explorative study indicate a clear difference and shift in the individual perceived relevance of attributes in these different settings. Another remarkable finding of this study is the predominant focus on impact attributes by the respondents and the less significant position of likelihood or probability. The majority of professionals seem to ignore likelihood in their security risk assessment. This might be due to so called probability neglect as introduced by other scholars. the security in organisations and society is depending on the assessment and judgement of these professionals, understanding their preferences and the influence of cognitive biases is paramount. This study contributes to this body of knowledge and might raise attention to this important topic in both the academic and professional security domain.
therapy ◼ time-to-treatment ◼ tissue-type plasminogen activator Baseline National Institutes of Health Stroke Scale–Adjusted Time Window for Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke

consecutive patients treated with alteplase according to the European Summary of Product Characteristics criteria. Patients were categorized according to National Institutes of Health Stroke Scale (NIHSS) severity in mild NIHSS ( ≤ 8), moderate NIHSS (9–15), and severe stroke NIHSS ( ≥ 16). We sequentially analyzed time-to-treatment to achieve favorable outcome (modified Rankin Scale ≤ 2 at 3 months). Results —Overall, 19.8% had mild, 30.3% had moderate, and 49.9% had severe stroke. Favorable outcome occurred in 79.1%, 60.8%, and 26.2%, respectively. In patients with mild stroke, younger age (odds ratio [OR], 0.88; 95% confidence intervals [CI], 0.8–0.95), no previous history of stroke (OR, 0.16; 95% CI [0.039–0.65]), and no proximal occlusion (OR, 0.183; 95% CI [0.038–0.89]) independently predicted favorable outcome. In patients with moderate stroke, age (OR, 0.95; 95% CI [0.92–0.98]), no proximal occlusion (OR, 0.362; 95% CI [0.17–0.75]), and time-to-treatment before 120 minutes (OR, 2.70; 95% CI [1.14–6.38]) emerged as independent predictors of favorable outcome. In patients with severe stroke, younger age (OR, 0.96; 95% CI [0.94–0.99]), lower previous modified Rankin Scale (OR, 0.42; 95% CI [0.21–0.82]), and absence of proximal occlusion (OR, 0.48; 95% CI [0.25–0.94]) appeared as independent predictors. Conclusions —The impact of time-to-treatment on favorable outcome varies widely depending on baseline stroke severity. The window for favorable outcome was ≤ 120 min for moderate strokes. However, time-to-treatment seemed unrelated to functional outcome in mild and severe stroke. ( Stroke . 2014;45:1059-1063.) and so on. ROC curves were also configured to establish the sensitivity and specificity of each time-to-treatment on long-term outcome. Multivariable logistic regression analyses were performed for each group to determine factors that could be considered as independent predictors of favorable outcome. Variables showing P <0.1 in univariate analysis were included in the multivariate model. A probability value of <0.05 was considered significant for all tests.
Long-term variability of the Be/X-ray binary A 0535+26 — I. Optical and UV spectroscopy

The results of a 7-yr optical and UV spectroscopic study of the high-mass X-ray binary A 0535+26 are presented. It was found that throughout the period of the observations the line profile of Hα showed considerable variability. A correlation between the equivalent width of Hα and both V-band magnitude and (B−V) colour excess was observed, albeit with considerable scatter present in the data set. A giant X-ray flare in early 1994 was accompanied by a fading in optical and infrared photometric bands, and a reduction in the equivalent width of Hα. When the star was observed in 1994 September, it was found to have developed a double-peaked Hα profile, and further observations saw the V/R peak ratio vary cyclically, with a period of ∼1 yr. If this is identified as a global one-armed oscillation, it becomes the shortest period ever observed in a Be star. The accompanying photometric and spectroscopic observations provide a test of any theory seeking to describe the onset and behaviour of such a density wave.
Multivariate Functional Principal Component Analysis for Data Observed on Di ↵ erent (Dimensional) Domains Online Supplement

⇤The authors acknowledge support from the German Research Foundation through Emmy Noether grant GR 3793/1-1. †Data used in preparation of this article were obtained from the Alzheimers Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this paper. A complete listing of ADNI investigators can be found at: http://adni. loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List. pdf. Data collection and sharing for the neuroimaging data in Section 5 was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI, National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). A detailed list of ADNI funding is available at http: //adni.loni.usc.edu/about/funding/. The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer’s Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California.
SCREENING OF BACTERIOCIN PRODUCING BACTERIA FROM SOIL SAMPLE AGAINST STAPHYLOCOCCUS AUREUS

In industrialized countries 30 percentage population suffer from food borne disease yearly. Food processing runs the risk of significant economic loss annually due to food spoilage resulting from microbial contamination. Although chemical preservatives may provide a solution, the use of such preservatives is generally avoided, since they have negative consequences for human health. Moreover, the problems associated with food safety especially of microbial contamination appear to be alarmingly high. To address the increasing bacterial resistance to conventional antibiotics, bacteriocins are now considered as alternative antimicrobials for the treatment of human and possibly animal infections. Further, processed foods without chemical preservatives are in demand by consumers. Research in natural antimicrobial agents such as bacteriocins becomes inevitable. Members of the Bacillus group are good producers of antimicrobial substances such as peptide and lipopeptide antibiotics, as well as bacteriocins. Interestingly, Bacillus represents an alternative genus for the identification of bacteriocins because it includes many industrial species and has a history of safe use in the food industry. In the present study screening of bacterial isolates for bacteriocin production were screened from soil samples, from them thirty bacterial isolates obtained were tested for the bacteriocin activity against indicator bacteria Staphylococcus aureus . Among them MA5 designated strain found to be Gram’s positive rod bacteria. Based on the phenotypical characterization identified as Bacillus sp. and exhibited antagonistic activity against S. aureus. The antagonistic bacterial strain MA5 found to inhibit the growth of S. aureus . Antibacterial activity was identified by agar well diffusion assay. The sensitivity of the indicator strains were estimated based on the inhibition zones. To estimate the molecular weight of the bacteriocin, SDS-PAGE was performed and the protein in the active fraction was resolved and the molecular weight of the single protein band that exhibited antimicrobial activity was estimated to be 10 kDa.
Conformational Unbending of Regulation of Cell Adhesion by Affinity and

Rapid activation of integrins in response to chemokine-induced signaling serves as a basis for leukocyte arrest on inﬂamed endothelium. Current models of integrin activation include increased afﬁnity for ligand, molecular extension, and others. In this study, using real-time ﬂuorescence resonance energy transfer to assess (cid:1) 4 (cid:2) 1 integrin conformational unbending and ﬂuorescent ligand binding to assess afﬁnity, we report at least four receptor states with independent regulation of afﬁnity and unbending. Moreover, kinetic analysis of chemokine-induced integrin conformational unbending and ligand-binding afﬁnity revealed conditions under which the afﬁnity change was transient whereas the unbending was sustained. In a VLA-4/VCAM-1-speciﬁc myeloid cell adhesion model system, changes in the afﬁnity of the VLA-4-binding pocket were reﬂected in rapid cell aggregation and disaggregation. However, the initial rate of cell aggregation increased 9-fold upon activation, of which only 2.5-fold was attrib-utable to the increased afﬁnity of the binding pocket. These data show that independent regulation of afﬁnity and conformational unbending represents a novel and fundamental mechanism for regulation of integrin-dependent adhesion in which the increased afﬁnity appears to account primarily for the increasing lifetime of the (cid:1) 4 (cid:2) 1 integrin/VCAM-1 bond, whereas the unbending accounts for the increased capture efﬁciency. The Journal of Immunology, 2007, 178: 6828–6839.
Moments of parton distribution amplitudes and structure functions for the light mesons from lattice QCD

This thesis presents the lattice calculation and the required renormalisation for the determination of two hadronic structure quantities. These are the parton distribution amplitudes (PDAs) which enter in the form-factor for exclusive scattering processes and the parton distribution functions (pdfs) that appear in inclusive processes. The PDA’s provide process independent partonic information about hadrons and are important quantities required for the calculation of weak physics parameters, such as CKM matrix elements and CP violating phases. We are able to calculate moments of the PDAs on the lattice using two point correlation functions of local operators. This calculation extracts the first two moments for the light mesons and is performed on three ensembles, with parameters, that enable a study of finite volume and discretisation effects. We use the Iwasaki gauge action and 2 + 1 flavours of domain wall fermions for all simulations. The calculation of the pdfs through the structure function moments uses three-point correlation functions of local operators. We extract the first odd moment for the pion on our finest lattice, using partially twisted boundary conditions. An important feature of both calculations is non-perturbative renormalisation, using the Rome-Southampton method. The effect of the projections used to isolate the desired renormalisation factors and the momentum choice, that sets the renormalisation scale, on the discretisation errors is detailed through the use of twisted boundary conditions. The results for all quantities are obtained to good precision.
IC S SPECTRAL SOLUTION OF THE VISCOUS BLUNT BODY PROBLEM. II: MULTIDOMAIN APPROXIMATION

We present steady solutions of high speed viscous flows over blunt bodies using a multidomain Chebyshev spectral collocation method. The region within the shock layer is divided into subdomains so that internal layers can be well-resolved. In the interiors of the subdomains, the solution is approximated by Chebyshev collocation. At interfaces between subdomains, the advective terms are upwinded and the viscous terms are treated by a penalty method. The method is applied to five flows the Mach number range 5-25 and Reynolds number range 2,000 - 83,000, based on nose radius. Results are compared to experimental data and to a finite difference result. aResearch ABSTRACT We present steady solutions of high speed viscous flows over blunt bodies using a multidomain Chebyshev spectral collocation method. The region within the shock layer is divided into subdomains so that internal layers can be well- resolved. In the interiors of the subdomains, the solution is approximated by Chebyshev collocation. At interfaces between subdomains, the advective terms are upwinded and the viscous terms are treated by a penalty method. The method is applied to five flows the Mach range 5-25 and Reynolds 2,000 83,000, based on nose radius. Results are compared to experimental data and to a finite difference result.
AN ASSESSMENT OF PUBLIC AND PRIVATE BENEFITS OF ORGANIC FARMING IN PAKISTAN

Despite the acknowledged advantages of organic farming, questions remain about its productivity differential and financial viability to its counterpart conventional farming. We test this claim in Pakistan, by comparing the productivity and profitability of organic and conventional farms that grow two major crops, wheat and rice, based on primary data collected from 444 (220 organic & 224 conventional) farms located in three districts of Punjab province. We find that growing organic crops is at least as profitable as conventional crops despite their low yields due to lower input costs and higher commodity prices. The Benefit Cost Ratio is also higher for organic crops which suggest that farmers can get higher profits by moving from conventional to organic crops. Overall, input costs are 20% and 10% lower in organic wheat and rice farms relative to their conventional counterparts. Soil nutrient tests show that organic farms tend to better conserve soil fertility and system stability than conventional farms. Based on these private and public benefits, we argue that organic agriculture should be encouraged to ensure sustainable agricultural practices in Pakistan. Farmers’ tentative adoption of commercial organic farming will largely depend on how demand for organically farmed food continues to grow.
Characterisation of Roman copper alloy artefacts and soil from Rakafot 54 (Beer Sheva, Israel)

– The research presented in this paper focused on the preliminary non-destructive analysis of copper alloys, corrosion, and soil components from a Roman archaeological site in Israel. pXRF, XRD, and micromorphological analyses were carried out to gain a better understanding of the corrosion processes affecting the copper alloy artefacts, by characterising the alloy composition, soil environments, and corrosion products. Preliminary results indicate that the artefacts consist of copper-lead-tin alloys, covered by copper hydroxy-chlorides and lead sulphate phases with slight variations in their crystallisation. The multi-analytical approach revealed the presence of quartz, calcite, gypsum and feldspars in the sediments, while thin sections more specifically indicate loess soils with local micro-environments.
DDDT_A_224771 2623..2636

Department of Metabolic Medicine/ Chemical Pathology, Guy’s & St Thomas’ Hospitals, London SE1 7EH, UK Abstract: Severe hypertriglyceridaemia is associated with pancreatitis and chronic pancreatitis-induced diabetes. Familial chylomicronaemia syndrome (FCS) is a rare autosomal recessive disorder of lipid metabolism characterised by high levels of triglycerides (TGs) due to failure of chylomicron clearance. It causes repeated episodes of severe abdominal pain, fatigue and attacks of acute pancreatitis. There are few current options for its long-term management. The only universal long-term therapy is restriction of total dietary fat intake to <10-15% of daily calories (15 to 20g per day). Many patients have been treated with fibrates and statins with a variable response, but many remain susceptible to pancreatitis. Other genetic syndromes associated with hypertriglyceridaemia include familial partial lipodystrophy (FPLD). Targeting apolipoprotein C3 (apoC3) offers the ability to increase clearance of chylomicrons and other triglyceride-rich lipoproteins. Volanesorsen is an antisense oligonucleotide (ASO) inhibitor of apoC3, which reduces TG levels by 70–80% which has been shown also to reduce rates of pancreatitis and improve well-being in FCS and reduce TGs and improve insulin resistance in FPLD. It is now undergoing licensing and payer reviews. Further developments of antisense technology including small interfering RNA therapy to apoC3 as well as other approaches to modulating triglycerides are in development for this rare disorder.
Application Cycles

This paper asserts that separation rate shocks are a dominant source of business cycle ﬂuctuations in the vacancy-to-unemployment ratio, overturning conventional wisdom. Motivated by new micro-data, I develop a richer model of the hiring process in which unemployed and employed workers decide what positions to apply for based on an imperfect signal of how good a ﬁt they would be, while ﬁrms screen applicants to determine whom to hire. Because the unemployed apply for many positions that they are unlikely to be a good ﬁt for, it is harder for ﬁrms to ascertain who is qualiﬁed for the job during periods of high unemployment, dampening incentives to create jobs. By highlighting an additional source of congestion in labor markets, I ﬁnd that separation rate shocks explain two thirds of business cycle volatility in the vacancy-to-unemployment ratio and generate a strong negative Beveridge curve, in line with the data.
Painting the Palace of Apries II

Fragments of painted limestone reliefs from the Palace of Apries in Upper Egypt excavated by Flinders Petrie in 1908–1910 have been investigated using visible-induced luminescence imaging, micro X-ray fluorescence, laser ablation inductively coupled plasma mass spectrometry, micro X-ray powder diffraction, and Fourier transform infrared spectrometry. The pigments have been mapped, and the use and previous reports of use of pigments are discussed. Mainly lead–antimonate yellow, lead–tin yellow, orpiment, atacamite, gypsum/anhydrite, and Egyptian blue have been detected. It is the first time that lead–antimonate yellow and lead–tin yellow have been identified in ancient Egyptian painting. In fact, this is the earliest examples known of both of these yellow pigments in the world.