Miracle-dz/UniFAR-FTUs huggingface dataset:
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15 A large spread exists in both Indian and Australian average monsoon rainfall and in their 16 interannual variations diagnosed from various observational and reanalysis products. While 17 the multi model mean monsoon rainfall from 60 models taking part in the Coupled Model 18 Intercomparison Program (CMIP3 and CMIP5) fall within the observational uncertainty, 19 considerable model spread exists. Rainfall seasonality is consistent across observations and 20 reanalysis, but most CMIP models have biases in monsoon season duration, with CMIP5 21 models generally performing better than CMIP3. 22 Most models reproduce the observed ENSO-Australian monsoon teleconnection, with the 23 strength of the relationship dependent on the strength of the simulated ENSO. However, over 24 the Maritime Continent, the monsoon-ENSO connection is generally weaker than observed, 25 depending on the ability of each model to realistically reproduce the ENSO signature in the 26 Warm Pool region. The Indian monsoon-ENSO relationship is affected by overly persistent 27 ENSO events in many CMIP models. It is also shown that models with stronger monsoon28 ENSO relationships generally have a stronger monsoon-IOD relationship. 29 Based on model fidelity in reproducing realistic monsoon characteristics and ENSO tele30 connections, we objectively select 13 ”best” models to analyze projections in the rcp8.5 31 scenario. Twelve of these models are from the CMIP5 ensemble. In India and Australia, 32 most of these models produce 5 to 20% more monsoon rainfall over the 21stcentury than 33 during the pre-industrial period. By contrast, there is no clear model consensus over the 34 Maritime Continent. 35
Current knowledge about Post-Polio Syndrome (PPS)

Introduction : PPS appears at least 15 years after polio virus infection, followed by stabilization of the neurological condition. In the course of the disease, there are neurological, musculoskeletal and general symptoms. The aim of the study : The article focuses on the current knowledge about post-polio syndrome. Material and method : Standard criteria were used to review the literature data. The search of articles in the PubMed, Google Scholar, ReaserchGate database was carried out using the following Description : There is no treatment that would cure PPS patients. However, interdisciplinary management focused on symptomatic treatment can significantly improve the quality of life of patients. One of the first solutions proposed to improve the clinical condition of patients with PSS was physical rehabilitation. In the treatment of post-polio syndrome, in addition to the use of non-pharmacological agents, therapy with the use of immunoglobulin infusions, the use of coenzyme Q10 or L-citrulline treatment has been introduced. Summary : Despite the fact that there is no specific treatment in PPS, it has been proven that non-pharmacological intervention (motor rehabilitation, lifestyle change, orthoses, respiratory assistance) has a beneficial effect on relieving the symptoms of the disease
Urbanization, economic growth, and environmental pollution

PurposeGiven the recent rapid economic development, the processes of industrialization and urbanization are accelerating. At the same time, the contradiction between environmental quality and economic development has become increasingly prominent and is likely to restrict the normal pace of China’s economic development and environmental protection. As such, the purpose of this paper is to incorporate the urbanization factor into an analytic framework to discuss the relationship among urbanization, economic development, and environmental pollution.Design/methodology/approachA panel data of 31 Chinese provinces from 2004 to 2015 is selected for this research. A spatial correlation test is first conducted on the environmental pollution status, then the spatial Durbin model is used to carry out spatial econometric testing of the relationship among the above three factors.FindingsInterprovincial environmental pollution in China has significant positive spatial correlation, environmental pollution discharge in most provinces is significantly stable, discharge of environmental pollutants is transitioning from coastal to inland provinces, and urbanization and economic growth can both aggravate environmental pollution, but economic growth can relieve environmental pollution in neighboring provinces.Originality/valueThe relationship between economic growth, urbanization, and environmental quality has always been an important issue for sustainable development. As such, China’s urbanization leads to economic development, while rapid economic growth and environmental pollution are coordinated. This paper focuses on the specific relationship between them. To this end, local governments make concerted efforts to formulate sound environmental regulation policies based on local environmental conditions, where economic development is an effective means of alleviating the contradictory relationship between economic development and environmental protection.
BODY MASS INDEX AS A PREDICTOR FOR OBSTRUCTIVE SLEEP APNEA IN SNORING PATIENTS

Background: Obstructive sleep apnea (OSA) is a very common disease in the general population that can cause deterioration in the quality of life, chronic diseases, road traffic accidents and excessive mortality in itself. The condition is characterized by repeated episodes of upper airway obstruction, accompanied by nocturnal oxygen desaturation, fragmented sleep and excessive daytime sleepiness. Objective: To evaluate body mass index (BMI) correlated to apnea-hypopnea index (AHI) and minimum O2 saturation (Nadir SaO2). Patients and Methods: A retrospective database analysis of medical records of One hundred fifty patients with OSA that performed at Almoosa Hospital, Saudi Arabia during the period from August 2016 to August 2019.BMI was calculated for each patient, as well as AHI and Nadir SaO2 recorded during polysomnography. AHI was used to evaluate the severity of OSA and to assess if there is correlation to BMI values. Results: The severity of OSA had significant positive correlation with BMI (ρ =0.13, P=0.005) and significant negative correlation with Nadir SaO2 (ρ = -0.27, P=0.001). BMI had significant negative correlation with Nadir SaO2 (ρ = -0.18, P=0.027). Conclusion: Higher BMI values were correlated with lower Nadir SaO2 during overnight polysomnography. Since hypoxia stress is a risk factor for cardiovascular diseases and alters the lipid metabolism, dietary consulting should be recommended in association with other treatment modalities for OSA.
Metagenomic analysis of the gut microbiota in piglets either challenged or not with enterotoxigenic Escherichia coli reveals beneficial effects of probiotics on microbiome composition, resistome, digestive function and oxidative stress responses

This study used metagenomic analysis to investigate the gut microbiota and resistome in piglets that were or were not challenged with enterotoxigenic Escherichia coli (ETEC) and had or had not received dietary supplementation with microencapsulated probiotics. The 72 piglets belonged to six groups that were either non-ETEC challenged (groups 1–3) or ETEC challenged (receiving 5ml of 109 CFU/ml pathogenic ETEC strain L3.2 one week following weaning at three weeks of age: groups 4–6). On five occasions at 2, 5, 8, 11, and 14 days of piglet age, groups 2 and 5 were supplemented with 109 CFU/ml of multi-strain probiotics (Lactiplantibacillus plantarum strains 22F and 25F, and Pediococcus acidilactici 72N) while group 4 received 109 CFU/ml of P. acidilactici 72N. Group 3 received 300mg/kg chlortetracycline in the weaner diet to mimic commercial conditions. Rectal faecal samples were obtained for metagenomic and resistome analysis at 2 days of age, and at 12 hours and 14 days after the timing of post-weaning challenge with ETEC. The piglets were all euthanized at 42 days of age. The piglets in groups 2 and 5 were enriched with several desirable microbial families, including Lactobacillaceae, Lachnospiraceae and Ruminococcaceae, while piglets in group 3 had increases in members of the Bacteroidaceae family and exhibited an increase in tetW and tetQ genes. Group 5 had less copper and multi-biocide resistance. Mobile genetic elements IncQ1 and IncX4 were the most prevalent replicons in antibiotic-fed piglets. Only groups 6 and 3 had the integrase gene (intl) class 2 and 3 detected, respectively. The insertion sequence (IS) 1380 was prevalent in group 3. IS3 and IS30, which are connected to dietary intake, were overrepresented in group 5. Furthermore, only group 5 showed genes associated with detoxification, with enrichment of genes associated with oxidative stress, glucose metabolism, and amino acid metabolism compared to the other groups. Overall, metagenomic analysis showed that employing a multi-strain probiotic could transform the gut microbiota, reduce the resistome, and boost genes associated with food metabolism.
Revealed consumers’ preferences for fresh produce attributes in Chinese online markets: A case of domestic and imported apples

Background The online market is getting popular today, and consumers’ preferences about products are revealed differently in online and offline markets. Especially, fresh food purchasing online is very different from non-food products due to its unique features such as perishability, low cost and frequent purchases, low value-volume ratio, and highly relevance to safety and health. However, studies on online fresh food are rather few, and this study will fill the gap by investigating consumers’ preferences for fresh food online purchasing. Methods Using unique data observed from online stores, we conduct a hedonic analysis of fresh produce online market using apple market in China, avoiding hypothetical bias. Propensity Score Matching is used to check the online promotion effects. The data are apples transactions from Jingdong JD e-commerce platform with sample size 8,200, observed across six weeks from 11/26/2018 to 12/31/2018. Variables used include prices, promotions, varieties, places of origin, fruit size, labeled as organic or green food, watercore label, and customer reviews for the products as well as for the venders. Results We found place of origin, food safety and eco-certificates, and sensory features all influence apple prices which reflect consumer preferences. In addition to product features, store features such as former customers’ review for the store, a video post of the product, and other latent product features through former customers’ review for the product quality also influence consumers’ preference reflected by price. Conclusions In additional to product intrinsic features, consumer show preferences and valuation for online market special features.
Doing well-being: Self-reported activities are related to subjective well-being

Activities and Subjective Well-Being (SWB) have been shown to be intricately related to each other. However, no research to date has shown whether individuals understand how their everyday activities relate to their SWB. Furthermore, the assessment of activities has been limited to predefined types of activities and/or closed-ended questions. In two studies, we examine the relationship between self-reported everyday activities and SWB, while allowing individuals to express their activities freely by allowing open-ended responses that were then analyzed with state-of-the-art (transformers-based) Natural Language Processing. In study 1 (N = 284), self-reports of Yesterday’s Activities did not significantly relate to SWB, whereas activities reported as having the most impact on SWB in the past four weeks had small but significant correlations to most of the SWB scales (r = .14 –.23, p < .05). In Study 2 (N = 295), individuals showed strong agreement with each other about activities that they considered to increase or decrease SWB (AUC = .995). Words describing activities that increased SWB related to physically and cognitively active activities and social activities (“football”, “meditation”, “friends”), whereas words describing activities that decreased SWB were mainly activity features related to imbalance (“too”, “much”, “enough”). Individuals reported both activities and descriptive words that reflect their SWB, where the activity words had generally small but significant correlations to SWB (r =. 17 –.33, p < .05) and the descriptive words had generally strong correlations to SWB (r = .39–63, p < .001). We call this correlational gap the well-being/activity description gap and discuss possible explanations for the phenomenon.
Comparison of serum and plasma as a source of blood extracellular vesicles: Increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions

Extracellular vesicles (EVs) have attracted much attention as potential diagnostic biomarkers for human diseases. Although both plasma and serum are utilized as a source of blood EVs, it remains unclear whether, how and to what extent the choice of plasma and serum affects the experimental results. To address this issue, in this study, we performed comprehensive characterization of EV fractions derived from plasma and serum, and investigated the differences between these blood EVs. We demonstrated by nanoparticle tracking analysis that EV fractions derived from serum contain more particles than those from plasma of mice. Proteomic analysis demonstrated that platelet-associated proteins are selectively enriched in serum EV fractions from both mice and humans. A literature review of proteomic data of human blood EVs reported by other groups further confirmed that selective enrichment of platelet-associated proteins is commonly observed in serum EVs, and confers different proteome profiles to plasma EVs. Our data provide experimental evidence that EV fractions derived from serum generally contain additional EVs that are released from platelets, which may qualitatively and quantitatively alter EV profiles when using serum as a source of blood EVs.
Survival effects of primary and metastatic surgical treatment in metastatic small intestinal tumors: A propensity score–matching study

Objective To analyze the effects of primary tumor resection and metastatic lesion resection on the survival of metastatic small intestinal tumors. Methods The research subjects were patients with metastatic small bowel tumors identified from 2004 to 2016 in the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching and Kaplan–Meier analyses were performed to analyze the effect of surgery on the prognosis. Results A total of 4,034 patients from the SEER database were analyzed. Both before and after the propensity score–matching analysis, the prognosis of patients who underwent primary tumor surgery and metastatic surgery was better than that of patients who did not undergo surgery; all were patients with metastatic small bowel adenocarcinoma (mSIA) or metastatic small intestinal neuroendocrine tumors (mSI-NETs) (all p < .005). Patients with mSIA and adequate lymph node dissection had a longer prognosis than mSIA patients with inadequate lymph node dissection, but this survival benefit was not present in mSI-NET patients. It made no difference in the prognosis of mSIA and mSI-NETs whether localized surgery or intestine-ectomy was performed. Patients with mSIA who underwent primary and metastatic excision plus chemotherapy had the best overall survival and cancer-specific survival rates, whereas mSI-NET patients who underwent primary and metastatic excision had the best overall survival and cancer-specific survival rates (all p < .001). Conclusion In these carefully selected patients, primary tumor resection and/or metastatic lesion resection significantly improved the survival rates for patients with mSIA and mSI-NETs. The mSIA patients with resectable primary tumors seemed to require a sufficient number of lymph node dissections more than the patients with well-differentiated mSI-NETs.
The prevalence of AstraZeneca COVID-19 vaccine side effects among Nigist Eleni Mohammed memorial comprehensive specialized hospital health workers. Cross sectional survey

Introduction The best way to eradicate corona virus disease (COVID-19) viral infection is mass vaccination. Many studies demonstrate vaccination is associated with some local and systemic side effects. This study aimed to provide evidence on AstraZeneca COVID-19 vaccine side effects. Methodology Institutional based cross-sectional survey was conducted among 254 health workers at Nigist Eleni Mohammed memorial comprehensive specialized hospital (from July 01/ 2021 to July 30/2021). Data were collected consecutively through self-administered online survey created on Google Forms of platform which had been randomly delivered via (Facebook or telegram pages). Demographic data of participants, side effect after first and second dose of vaccine were covered. Result The prevalence of at least one side effect after first dose was 91.3% and after second dose was 67%. Injection site pain (63.8% vs. 50.4%), headache (48.8% vs. 33.5%), fever (38.8% vs. 20.9%), muscle pain (38.8% vs. 21.7%), fatigue (26% vs. 28.7%, tenderness at the site (27.6% vs. 21.7%), and joint pain (27.6% vs. 20.9%) were the most commonly reported side effects after first and second dose vaccine respectively. Most of participants reported that their symptoms emerged after 6hr of vaccination and only less than 5% of participant’s symptoms lasted more than 72hr of post vaccination. The younger age (≤29 year) were more susceptible to at least one side effect (χ 2 = 4.2; p = 0.04) after first dose. Conclusion The prevalence of side effect after first and second dose vaccine was higher. Most of the symptoms were short lived and mild. This result might help to solve an emerging public health challenge (vaccine hesitancy) nurtured by misinformation related to vaccines safety.
Characterizing Medicine Quality by Active Pharmaceutical Ingredient Levels: A Systematic Review and Meta-Analysis across Low- and Middle-Income Countries

ABSTRACT. Substandard and falsified medicines are often reported jointly, making it difficult to recognize variations in medicine quality. This study characterized medicine quality based on active pharmaceutical ingredient (API) amounts reported among substandard and falsified essential medicines in low- and middle-income countries (LMICs). A systematic review and meta-analysis was conducted using PubMed, supplemented by results from a previous systematic review, and the Medicine Quality Scientific Literature Surveyor. Study quality was assessed using the Medicine Quality Assessment Reporting Guidelines (MEDQUARG). Random-effects models were used to estimate the prevalence of medicines with < 50% API. Among 95,520 medicine samples from 130 studies, 12.4% (95% confidence interval [CI]: 10.2–14.6%) of essential medicines tested in LMICs were considered substandard or falsified, having failed at least one type of quality analysis. We identified 99 studies that reported API content, where 1.8% (95% CI: 0.8–2.8%) of samples reported containing < 50% of stated API. Among all failed samples (N = 9,724), 25.9% (95% CI: 19.3–32.6%) reported having < 80% API. Nearly one in seven (13.8%, 95% CI: 9.0–18.6%) failed samples were likely to be falsified based on reported API amounts of < 50%, whereas the remaining six of seven samples were likely to be substandard. Furthermore, 12.5% (95% CI: 7.7–17.3%) of failed samples reported finding 0% API. Many studies did not present a breakdown of actual API amount of each tested sample. We offer suggested improved guidelines for reporting poor-quality medicines. Consistent data on substandard and falsified medicines and medicine-specific tailored interventions are needed to ensure medicine quality throughout the supply chain.
The Reparative Effects of Radio Electric Asymmetric Conveyer Technology on Facial Injuries: A Report of Two Cases

Facial injuries are often caused by accidental traumas and can be devastating, as their aesthetic outcomes can impact the social relationships and self-esteem of the patient. The reparative processes can be delayed and hindered by the alteration of the endogenous bioelectric activity (EBA) in the damaged tissues, caused by the trauma. In fact, the proper maintenance and generation of EBA is a prerequisite for the cellular health of any tissue and the alteration of EBA determines the inhibition of any cellular repair process, affecting even the cellular differentiation processes. The radio electric asymmetric conveyer (REAC) technology for neurobiological stimulation treatments was designed precisely to restore EBA in both superficial and deep tissues. The two cases of facial trauma presented in this report were treated with the noninvasive treatment of reparative tissue optimization (TO-RPR) applied with REAC technology. The results showed that the REAC TO-RPR treatment can quickly and safely optimize the reparative processes of the tissues, inducing a homogeneous, synchronized, and coordinated recovery, regardless of the type and the aging of the injured tissue and the severity and depth of the lesions.
How language skills and working memory capacities explain mathematical learning from preschool to primary school age: Insights from a longitudinal study

Between the age span of 3 to 6 years the foundation for children’s mathematical learning (i.e., numerical abilities and cognition) are laid. However, the developing relations between mathematical skills, language, and working memory starting at preschool age and evolving into primary school age are not well understood. Adopting an empirically validated analysis model, the present study examines in detail longitudinal interdependencies between mathematical skills, a wide range of language skills, and working memory components underlying the mathematical learning process of 41 German preschool children (41.5% female) spanning ages 4 to 6. Phonological processing skills and expressive grammar skills emerged as the most significant language skills for the process of children’s mathematical learning across the investigated age span. Within the latter, children’s phonological processing skills and expressive grammar skills were supported by children’s word expression abilities. The phonological loop emerged as the most important working memory component for children’s early mathematical learning between ages 4 to 6. Furthermore, a wide array of language skills were associated with complex information and storage processes within this mathematical learning process. In conclusion, the present findings provide a more detailed and deeper insight into the learning process of children’s number concept, emphasizing the influence of phonological and particularly grammatical skills.
Infection Escherichia coli the Brain following TRIL Is Involved in Cytokine Production in

TLR4 interactor with leucine-rich repeats (TRIL) is a brain-enriched accessory protein that is important in TLR3 and TLR4 signaling. In this study, we generated Tril 2 / 2 mice and examined TLR responses in vitro and in vivo. We found a role for TRIL in both TLR4 and TLR3 signaling in mixed glial cells, consistent with the high level of expression of TRIL in these cells. We also found that TRIL is a modulator of the innate immune response to LPS challenge and Escherichia coli infection in vivo. Tril 2 / 2 mice produce lower levels of multiple proinﬂammatory cytokines and chemokines speciﬁcally within the brain after E. coli and LPS challenge. Collectively, these data uncover TRIL as a mediator of innate immune responses within the brain, where it enhances neuronal cytokine responses to infection. The Journal of Immunology , 2014, 193: 000–000.