Miracle-dz/UniFAR-FTUs huggingface dataset:
THE INFLUENCE OF RUGBY LEAGUE GAME QUALITY ON INDIRECT MARKERS OF MUSCLE DAMAGE

[Extract] Gabbett and colleauges investigated the physical demands on elite rugby league players when competing against a top 4 team in comparison to a bottom 4 team. Overall, they concluded that greater physical demands occur when competing during better performing games. To date, however, it is unclear whether the quality of a game based on level of physical exertion (e.g. number of tackles, number of sprints, running distance) influences a player’s level of fatigue post game. Given that CK and perceived soreness has shown to rise for 24-72 hours post rugby league games, often generic recovery protocols are incorporated without reference to an athletes' level of fatigue could be delayed by several days. However, having an ability to estimate an athlete's post-match fatigue based on their performance during the game may allow coaches to modify training programs in a short timeframe. Subsequently, the current study will examine whether games that produced higher CK levels 48 hours post-match are consistent with higher perceived soreness and physical demands during those games.
The characteristics of antimicrobial resistance and treatment of carbapenem-resistant Enterobacteriaceae infections in children from 2013 to 2018 in a chinese tertiary hospital

Background The aim of this study was to performe a retrospective analysis of prevalence and treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections in children in a tertiary hospital. Methods The non-repeat clinical isolates of CRE in children were collected in Liaocheng People's Hospital from January, 2013 to December, 2018. The bacterial identification and antibiotic susceptibility was performed according to the standard methods. The isolated strains will be detected carbapenemases genotypes and homology analysis. All data on the culture-positive strains and associated clinical infection from different pediatric wards were reviewed. Results A total of 20 CRE strains isolated from pediatric patients, which derived from different infection sites and present a classification of multiple species of Enterobacteriaceae. And the production of IMP-type carbapenemase in these strains is the main reason of antimicrobial resistance. Most of the infected patients have severe comorbidities and invasive procedures, and use insensitive drugs due to the high resistance rates and medication restrictions. Nevertheless, most infected children have been treated despite the resistance of pathogens to multiple antimicrobial agents. In our follow-up survey, most children received adjuvant therapy such as human intravenous immunoglobulin, which may be an important factor in helping patients defeat pathogenic bacteria. Conclusions This study demonstrates a high prevalence of IMP-mediated CRE infection in pediatric patients with severe comorbidities and invasive procedures. Most children have been cured, which may be related to application of adjuvant therapy and weaker pathogenicity of the IMP-type Enterobacteriaceae.
CBR

For More see Online Gallery: FHV-1 Images by Dr. Alison Clode at cliniciansbrief.com/FHVonline-gallery Renal amyloidosis (RA) is generally idiopathic but can be associated with chronic inflammation, infection, or neoplasia. Familial amyloidosis has been described in the Chinese shar-pei (CSP) dog. Reactive amyloidosis in the dog is often associated with progressive chronic kidney disease (CKD) with primary glomerular involvement; however, in CSPs renal medullary lesions predominate. Extrarenal amyloid deposition has also been reported. Up to 23% of CSPs are affected by Familial SharPei Fever (FSF), which may predispose CSPs to systemic reactive amyloidosis.
Exosome-Mediated siRNA pool Inhibits Axonal Growth Inhibitor in Cortical Neurons of Spinal Cord Injury in Rats

Background: As exosomes have been confirmed as a reservoir of siRNAs involved in certain diseases, the current study aims to investigate whether exosomal-siRNA could exert a protective role in spinal cord injury (SCI). Methods and Results: Exosomes in our experiment were isolated from lysosomal membrane-associated protein 2b (Lamp2b) overexpression HEK 293T cells, and purity of exosomes was characterized by the expression of CD9, CD47, and CD63 via western blot. Furthermore, the siRNA pool contains four siRNAs including siRNA-NgR, siRNA-LINGO-1, siRNA-Troy, and siRNA-PTEN was loaded to the exosomes, which indicated a significant role for the siRNA pool in reducing the expression of axon growth inhibitory factors. Upon the completion of loading into exosomes (exo-siRNA pool), the exo-siRNA pool was injected into primary cortical neurons of the SCI model in rats before cell proliferation and Rho expression were determined With the results revealed that purified addition could be applied to future experiments. The exo-siRNA pooled transfection caused downregulation of axon growth suppressors in primary cortical neurons including Nogo receptors (NgR), leucine-rich repeats and immunoglobulin domain-containing protein 1 (LINGO-1), Troy, and phosphatase and tenson homolog (PTEN). Cell proliferation and Rho expression of primary cortical neurons inhibited the expression of axonal growth inhibitors in rats with SCI by transfecting exogenous Sirna. Conclusion: This study confirmed that exosomes derived from Lamp2b overexpression HEK 293T cells facilitated both the recovery of functions and the survival of neurons when being loaded with the siRNA pool.
Victims of Cyberbullying: An Examination of Social Cognitive Processes Associated with Cyberbullying Victimization

ABSTRACT It has been consistently demonstrated that cyberbullying victimization is associated with poor mental health. This is of growing concern as access to the internet is increasing among adolescents. To ameliorate the negative impacts of victimization the role of coping self-efficacy has been extensively investigated in the context of face-to-face bullying, but has received little examination in the cyber context. The aim of the present study was to redress this omission by investigating the role of coping self-efficacy in mediating the relationship between cyberbullying victimization and depression. Adolescents aged between 11 and 16 years from independent schools in a large urban city in Australia participated in this study (51% Anglo/Celtic). High levels of cyberbullying victimization were related to high levels of depression. In addition, lower coping self-efficacy was related to higher depression, and this was evident for all the coping self-efficacy subscales. Consistent with research involving face-to-face victimization, it was shown that coping self-efficacy for avoiding self-blame and self-efficacy for proactive behavior partially mediated the relationship between cyberbullying victimization and depression. Implications of these findings for intervention programs and future research are discussed.
Le caratteristiche delle imprese insolventi

Il capitolo ha lo scopo di descrivere le caratteristiche statistiche attribuibili a 322 imprese che, in un campione di 9.208 PMI italiane, si sono rese insolventi dopo tre anni, nel periodo 2006-2010. In particolare, si focalizza l’attenzione sulle peculiarita delle imprese in termini di redditivita netta, redditivita operativa, efficienza, rotazione, struttura finanziaria, elasticita dell’attivo e liquidita. L’analisi statistica dimostra la maggiore rilevanza della struttura finanziaria rispetto a quella economica. Parole chiave: struttura del capitale, previsione delle insolvenze, rating. This chapter aims to analyze the statistical features associated to 322 firms that, in a sample of 9.208 Italian SMEs, result in default after three years, over the period 2006-2010. The focus is on net earnings, operating profitability, efficiency, turnover, financial structure, asset turnover and liquidity. The statistical analysis highlights that the financial structure of firms is more relevant than the economic structure. Key words: capital structure, bankruptcy prediction, rating
Micro-simulation modelling of ITS measures on the Ben Schoeman highway

The last couple of decades have brought about a paradigm shift in the way professionals view land transport. The original line of thought was to predict (Traffic flow) and provide (Infrastructure). The concern now is more about managing our existing road networks and infrastructure, but also ensuring that the effects of the newly constructed roads are appropriately forecasted. Intelligent Transport systems (ITS) are one of the measures applied to improve traffic conditions. It appears that the use of microscopic simulation models is needed to estimate the effects of ITS measures This study investigates the applicability of the micro-simulation software Paramics in the South African context by modelling the Ben Schoeman Highway between Pretoria and Johannesburg. ITS measures that have been investigated are: • Bus and High Occupancy Vehicle (HOV) lanes, • Variable Speed Limits (VSL) using variable Message Signs (VMS), and • Ramp metering.
Supplemental information from SP43 evaluation of system options for residential forced-air heating

ASHRAE Special Project 43 (SP43) has developed a dynamic simulation model for assessing the annual thermal performance and energy utilization of forced-war-air heating systems. Six previous papers on the SP43 project have described the model, its validation, and its use for evaluating system and control options, with the objective of generating information for the ASHRAE Handbook. A previous paper described the results of model predictions that showed the effect of system and control variables on overall performance. These variables include furnace and venting types, installation location and combustion air source, furnace sizing, night setback, thermostat cycling rate, blower operation strategy, basement insulation levels, duct sealing and insulation, house and foundation type, and climate. This paper describes the results of 25 additional model predictions that supplement those previously made -- including furnace sizing, climate for cases with night setback, blower afterrun control strategy, condensing furnaces with direct vents, closet furnace installations using attic air for combustion, and crawl-space furnace installations. The combined results of these predictions are expected to be the basis for information on annual system performance for the ASHRAE Handbook - 1988 Equipment Volume.
Effects of a developmental boot camp: Improving student performance on a college placement test

Heather Hill. EFFECTS OF A DEVELOPMENTAL BOOT CAMP: IMPROVING STUDENT PERFORMANCE ON A COLLEGE PLACEMENT TEST. (under the direction of Dr. Gary Kuhne) School of Education, Liberty University, April, 2012. Nationwide, students are entering college unprepared for college-level work. Recent high school graduates are placing into developmental courses at an alarming rate. The purpose of this research study is to examine the effect of a developmental boot camp on standardized placement test scores of students enrolling at a community college in North Carolina. The study has a quasi-experimental non-equivalent control group design. Collected data will include participants’ scores on the pretest and posttest placement test. A control group of eligible students who chose not to participate will be posttested for comparison. Instruments include ASSET ® placement test and Computer-Adaptive Placement Assessment and Support System. Results showed an improvement in numerical and algebra scores but no significant change in English scores. Descriptors: Developmental courses, college placement, remediation, boot camp
ANFIS Based Optimal Routing using Group Teaching and Adaptive Equilibrium Optimization based Trust Aware Routing Protocol in MANET

Recently, routing is considered the main problem in MANET due to its dynamic nature. The route discovery and the optimal route selection from the multiple routes are established for the efficient routing in MANET. The major objective of this research is to select the optimal route for packet transmission in MANET. In this paper, four stages namely trust evaluation, route discovery, optmal route selection and route maintanance are elucidated. Initially, the trust evaluation is made by using ANFIS where the primary trust values are evaluated. The next stage is the route discovery scheme, in which the routes are established by Group teaching optimization algorithm (GTA). From the route discovery scheme, multiple routes are found. The optimal route for the transmission is selected with the help of the Adaptive equilibrium optimizer (AO) algorithm. Finally, the route maintenance process is established; if any of the routes fails for the broadcast it immediately selects the alternate optimal route from the multi-zone routing table for efficient packet transmission. The proposed approach is evaluated by various performance measures like throughput, energy consumption, packet delivery ratio, end-to-end delay, packet loss rate, detection rate, and routing overhead. This result describes that the proposed approach outperforms other state-of-art approaches.
The prostate cancer drug enzalutamide shortens anogenital distance in male rat offspring by blocking the androgen receptor

Background: Enzalutamide is a non-steroidal anti-androgen drug used to treat prostate cancer. It is a potent androgen receptor (AR) antagonist, with an in vitro Lowest Observed Effect Concentration (LOEC) of 0.05 μM. In this study, we wanted to assess its utility as a model compound for future mechanistic studies aimed at delineating mechanism-of-action of anti-androgenic effects in the developing fetus. Methods: Enzalutamide in vitro activity was tested using an Androgen receptor reporter assay (AR-EcoScreenTM) and a steroidogenesis assay (H295R assay). For in vivo characterization, pregnant Sprague-Dawley rats were exposed to 10 mg/kg bw/day enzalutamide from gestational day 7-21. At gestational day 21, enzalutamide exposure concentrations were measured both in amniotic fluids and fetal plasma, alongside Anogenital distance (AGD). Fetal testes were collected and for testosterone measurements and gene expression profiling. Results: Enzalutamide was a strong AR antagonist in vitro and we also observed disrupted androgen synthesis in the H295R steroidogenic assay with a LOEC of 3.1 μM. In utero exposure resulted in about 20% shorter anogenital distance (AGD) in male fetuses. , as well as signs of dysregulated expression of the steroidogenic genes Star, Cyp11a1 and Cyp17a1 in the fetal testes at gestational day 21. Intra-testicular testosterone levels were unaffected. Conclusions: Based on these observations, together with in vitro LOECs and the fetal plasma levels of enzalutamide, we propose that the effect on male AGD was caused by AR antagonism rather than suppressed androgen synthesis. Due to the characteristic mechanism of action of enzalutamide, we suggest to use it as a new model compound in research on anti-androgenic environmental chemicals.
A Pragmatic Trial of Active Versus Passive Teaching for Clinically Integrating Evidence Based Medicine Teaching in an Undergraduate Medical School.

Background Clinically integrated Evidence Based Medicine (EBM) teaching promotes higher order application of knowledge, skills, and behaviours. There is, however, limited evidence on the most efficient model for clinically integrating EBM teaching. The aim of this study was to test the feasibility of integrating EBM teaching into clinical placements in an undergraduate medical school and compare the effectiveness of two different methods of EBM teaching - active teaching and passive teaching. Methods Active teaching involved blended learning methods and facilitated small group discussions. Passive teaching involved self-directed small group discussions and a remote live telecast taught session. Students’ EBM competencies were assessed using the Assessing Competency in EBM (ACE tool) and Educational Prescriptions (EP) and in summative final professional written and clinical examinations.Results Education was delivered to 65 students, of whom 45 received active teaching, while 20 received passive teaching. Students receiving active teaching performed better in EPs (MD=-2.28, -4.31, -0.26). There was no significant difference in performances in the ACE tool (MD=-1.02, -2.20, 0.16); the written final professional exams (MD=-0.11, -0.65, 0.44) and the EBM OSCE stations (MD=-0.81, -2.38, 0.74). Conclusions It was feasible to integrate EBM teaching into clinical placements in an undergraduate medical school. Both active and passive methods were effective in delivering EBM teaching. While students in the active teaching model scored higher in EPs; there was no significant difference in performances in the ACE tool or the summative assessments. Scaffolding student learning or a spiral approach to EBM teaching model provides a great example of continually shifting the zone of proximal development.
Biologically Adapted Radiotherapy on the Basis of Hypoxia Imaging with Positron Emission Tomography

A method is presented to identify and quantify hypoxia in human head-andneck tumours based on dynamic [18F]-Fmiso PET patient data, using a model for the tracer transport. A compartmental model was developed, inspired by recent immunohistochemical investigations with the tracer pimonidazole. In order to take the trapping of the tracer and the diffusion in interstitial space into account, the kinetic model consists of two compartments and a specific input function. This voxel-based data analysis allows us to decompose the time-activity curves (TACs) into their perfusion, diffusion and hypoxia-induced retention components. This characterization ranges from well perfused tumours over diffusion limited hypoxia to strong hypoxia and necrosis. The overall shape of the TAC and the model parameters may point at the structural architecture of the tissue sample. The model addresses the two main problems associated with hypoxia imaging with PET. Firstly, the hypoxic areas are spatially separated from well perfused vessels, causing long diffusion times of the tracer. Secondly, tracer uptake occurs only in viable hypoxic cells, which constitute only a small subpopulation in the presence of necrosis. The resulting parameters such as the concentration of hypoxic cells and the perfusion are displayed in parameter plots (‘hypoxia map’). Quantification of hypoxia performed with the presented kinetic model is more reliable than a criterion based on static standardized uptake values (SUV) at an early timepoint, because severely hypoxic/necrotic tissues show low uptake and are thus overlooked by SUV threshold identification. The derived independent measures for perfusion and hypoxia may provide a basis for individually adapted treatment planning. (Some figures in this article are in colour only in the electronic version) 0031-9155/05/102209+16$30.00 © 2005 IOP Publishing Ltd Printed in the UK 2209 2210 D Thorwarth et al
Simulating the ITER Plasma Startup Scenario in the DIII-D Tokamak

DIII-D experiments have investigated ITER startup scenarios, including an initial phase where the plasma was limited on low field side (LFS) poloidal bumper limiters. Both the original ITER 'small-bore' (constant q{sub 95}) startup and a 'large-bore' lower internal inductance (l{sub i}) startup have been simulated. In addition, l{sub i} feedback control has been tested with the goal of producing discharges at the ITER design value, l{sub i}(3) = 0.85. These discharges have been simulated using the Corsica free boundary equilibrium code. High performance hybrid scenario discharges ({beta}{sub N} = 2.8, H{sub 98,y2} = 1.4) and ITER H-mode baseline discharges ({beta}{sub N} > 1.6, H{sub 98,y2} = 1-1.2) have been obtained experimentally in an ITER similar shape after the ITER-relevant startup.
The estimation of the rate of change of yawing moment with sideslip

"Wind-tunnel data are presented on the rate of change of yawing moment with sideslip for tests of 9 complete airplane models, 20 fuselage shapes, and 3 wing models with various combinations of dihedral, sweepback, and twist. The data were collected during a survey of existing information, which was made to find a reliable method of computing the yawing moment due to sideslip. Important errors common to methods of computation used at present appear to be due to large interference effects, the investigation of which will undoubtedly require an extensive program of systematic wind-tunnel tests. At present it is necessary to place considerable reliance on past design experience in proportioning an airplane so as to obtain a reasonable degree of directional stability" (p. 1).
NUMERICAL SIMULATION OF THE TURBULENT FLOW PAST UPWIND YACHT SAILS

Thesow past upwind yacht sails is simulated using the commercial computational suids dynamics software FLUENT. The high Reynolds number of the sows dictates the use of turbulence models. The two—equation models available in FLUENT at the time of this work (k − " ,R NGk − " and realizable k − " ) are tested thoroughly using the backward facing step problem prior to their application to sail sows. The backward facing step problem is suitable as the sow involves complex turbulent behavior that is similar in nature to the sow past upwind sails. Two near—wall modelling options (wall functions and near—wall zonal model) are included in the tests. The realizable k − " model with wall functions is shown to be the best available method in the pack- age. Simulations of sow past two—dimensional sail sections conÞrm this result. Computations were also carried out for two different mast designs. Solutions of three—dimensional sows past America's Cup upwind sails were found to be useful for qualitative comparisons. Both 2D and 3D viscous sow results com- pare favorably to the results calculated by panel methods traditionally used in the sailing industry. As evident from the special issue on sail sow analysis of this journal (7) (1996), Computational Fluid Dynamics (CFD) is frequently used in the sail design process. Traditional computational packages in sail design are mostly based on vortex-lattice or panel methods and are generally only applied to close-hauled sailing situations where the sow remains attached. Because of the availability of affordable off-the- shelf viscous CFD packages, sail designers are increasingly tempted to use viscous sow solvers for both upwind and downwind sails and masts. The questions we address in this and ensuing publications is whether commer- cial viscous CFD codes are indeed suitable for reliable and accurate sail design and performance analysis, what the advantages are of using these codes over the traditional, and much cheaper, panel codes, and which of the turbulence models frequently employed in these codes should be used. In this Þrst work, which was carried out for Team New Zealand's design team, we focussed on upwind sail design. We used the commercial CFD software FLUENT 5.0, and tested the two-equation turbulence models available in this version (k − e, realizable k − e ,a nd RNGk − e). They are summarized in section 2. Near-wall modeling options were also investi- gated, comparing the performance of wall functions with a near-wall zonal model. The numerical solver used is described in section 3. Currently there are no 2D or 3D experimental sail sow data available in the public domain that are of sufficient accuracy to be used for code validation. We