Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of clozapine doses and tolerability in patients with and without concurrent valproic acid

Introduction Valproic acid (VPA) and its various formulations can be given in conjunction with clozapine for seizure prophylaxis or for augmentation in schizophrenia. There is conflicting literature on how VPA affects clozapine metabolism and the incidence of clozapine-related side effects. The purpose of this study is to compare the effects of VPA when given concurrently with clozapine to patients on clozapine monotherapy. Methods A retrospective medical record review was completed to identify patients admitted to the inpatient psychiatry unit at an academic medical center with an order for clozapine with and without concurrent VPA from August 7, 2010 to August 7, 2020. The primary outcome was the difference in clozapine doses in patients on clozapine as monotherapy versus dual therapy with VPA. Secondary outcomes include the difference in incidence of adverse effects in monotherapy versus dual therapy, as well as clozapine and norclozapine concentrations in both treatment groups. Results During the study period, 73 patients were included in the monotherapy group and 35 patients were included in the dual therapy group. The average clozapine dose in the dual therapy group was 250 mg (95% CI = 194.7, 305.4) which was significantly higher than the average monotherapy dose of 175.9 mg (95% CI = 134.0, 208.7; P = .016). However, there was no significant difference in the average clozapine concentration between the dual therapy group (392.5 ng/mL; 95% CI = 252.8, 532.2) and monotherapy group (365.9 ng/mL; 95% CI = 260.5, 471.3; P = .756). There were higher rates of tachycardia (45.7% vs 17.8%; P = .002), sedation (51.4% vs 8.2%; P < .001), and constipation (42.8% vs 9.5%; P < .001) in the dual therapy group compared to the monotherapy group, respectively. Discussion Patients on concurrent clozapine and VPA received higher doses of clozapine and experienced a higher incidence of tachycardia, sedation, and constipation.
Comparison of the Social Impact of Review Articles with Original Research Articles in the Field of Library and Information Science Indexed in WoS

The purpose of this study was to compare the social impact of review articles with the original research articles in the field of Library and Information Science indexed in Web of Science. This research has been done in terms of the purpose of the applied type and in terms of methodology is survey with the Altmetric analysis approach. The study population in this study consists of review and original research articles in the field of Library amd Information Science. The results of the review of research questions showed that there is a significant difference between review articles and original research articles in terms of reading in Mendeley, sharing on Twitter, receiving citations in Wikipedia, and No significant differences between the reflection of review and original research articles in News media and policy. The results showed, the social impact of review articles was more than original research articles. So the results show the importance of review articles in the body of scientific publications. Accordingly, it is necessary for writers and researchers and subsequently scientific journals, realizing the importance of these articles in the development of science interactions with society, to pay more attention to their acceptance and publication.
Enjoyment or Indulgence? Social Media Service Usage, Social Gratification, Self-Control Failure and Emotional Health

Social networking site smartphone applications have been widely used among Chinese young adults. However, less is known about their effects on emotional health and the mechanisms through which they function. This study analyzes the relationship between college students’ smartphone social networking service use patterns, social gratification, social media self-control failure, and emotional health. Data was collected from 360 college students in China via application log tracking and a self-administered questionnaire. Structural equation modeling results showed that, after controlling for demographic variables, the use of video social networking site smartphone applications was associated with decreased social gratification, and ultimately, adverse emotional health. Using social networking site smartphone applications late at night exhibited worse emotional health via more social media self-control failure. The implications for designing and using social media applications are discussed.
Experimental investigation of wave boundary layers with a sudden change in roughness

This study deals with turbulent oscillatory boundary-layer flows over a plane bed with a sudden spatial change in roughness. Two kinds of ‘change in the roughness’ were investigated: in one, the roughness changed from a smooth-wall roughness to a roughness equal to 4.8 mm, and in the other, it changed from a roughness equal to 0.35 mm to the same roughness as in the previous experiment (4.8 mm). The free-stream flow was a purely oscillating flow with sinusoidal velocity variation. Mean flow and turbulence properties were measured. The Reynolds number was 6 × 106 for the major part of the experiments, with a maximum velocity of approximately 2 m/s and the stroke of the motion about 6 m. The response of the boundary layer to the sudden change in roughness was found to occur over a transitional length of the flow. The bed shear stress over this transitional length attains a peak value over the bed section with the larger roughness. It was found that the amplification in the bed shear stress due to this peak could be up to 2.5 times its asymptotic value. Also, it was found that the turbulence is quantitatively different in the two half periods; a much stronger turbulence is experienced in the half period where the flow is towards the less-rough section. The present experiments further showed that a constant streaming occurs near the bed in the neighbourhood of the junction between the two bed sections. This streaming is directed towards the section with the larger roughness.
The Structure and Annual Variation of Antisymmetric Fluctuations of Tropical Convection and Their Association with Rossby-Gravity Waves.

Abstract The signature of 4–5-day period Rossby–gravity waves is searched for in the tropical convection field across the Indian-Pacific oceans. The convergence/divergence field of these waves in the lower troposphere is anticipated to produce an antisymmetric fluctuation in tropical convection. Antisymmetric fluctuations of tropical convection are shown to exhibit a pronounced spectral peak at a 4–5-day period only during boreal fall and only within about 30° longitude of the date line. The peak amplitude occurs around 7.5° latitude. These fluctuations propagate westward at 15–20 m s−1 with zonal wavelength of about 7000&–9000 km. The fluctuations of convection are coherent and out of phase with the equatorial meridional wind, which also exhibits a pronounced spectral peak at a 4–5-day period in the lower troposphere near the date line. The antisymmetric zonal wind also is strongly coherent with the antisymmetric convective fluctuations in this region. The horizontal distributions of the 4–5-day power an.
Modified Maxwell-Garnett equation for the effective transport coefficients in inhomogeneous media

The well known Maxwell-Garnett equation for the effective diffusion coefficient in two-phase media (a matrix with spherical inclusions) is modified in order to describe a wide range of experimental situations. This novel approach correctly treats the partial trapping of a diffusing particle by an inclusion as well as the consequences of an energy barrier for the particle penetration into an inclusion.
NFκB-Mediated Expression of Phosphoinositide 3-Kinase δ Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells

Epithelial mesenchymal transition (EMT) plays a vital role in a variety of human diseases including proliferative vitreoretinopathy (PVR), in which retinal pigment epithelial (RPE) cells play a key part. Transcriptomic analysis showed that the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway was up-regulated in human RPE cells upon treatment with transforming growth factor (TGF)-β2, a multifunctional cytokine associated with clinical PVR. Stimulation of human RPE cells with TGF-β2 induced expression of p110δ (the catalytic subunit of PI3Kδ) and activation of NFκB/p65. CRISPR-Cas9-mediated depletion of p110δ or NFκB/p65 suppressed TGF-β2-induced fibronectin expression and activation of Akt as well as migration of these cells. Intriguingly, abrogating expression of NFκB/p65 also blocked TGF-β2-induced expression of p110δ, and luciferase reporter assay indicated that TGF-β2 induced NFκB/p65 binding to the promoter of the PIK3CD that encodes p110δ. These data reveal that NFκB/p65-mediated expression of PI3Kδ is essential in human RPE cells for TGF-β2-induced EMT, uncovering hindrance of TGF-β2-induced expression of p110δ as a novel approach to inhibit PVR.
Chorus-driven resonant scattering of diffuse auroral electrons in nondipolar magnetic fields

[1] We perform a comprehensive analysis of resonant scattering of diffuse auroral electrons by oblique nightside chorus emissions present along a field line with an equatorial crossing of 6 RE at 00:00 MLT, using various nondipolar Tsyganenko magnetic field models. Bounce-averaged quasi-linear diffusion coefficients are evaluated for both moderately and actively disturbed geomagnetic conditions using the T89, T96, and T01s models. The results indicate that inclusion of nondipolar magnetic field leads to significant changes in bounce-averaged rates of both pitch angle and momentum diffusion for 200 eV to 10 keV plasma sheet electrons. Compared to the results using a dipole field, the rates of pitch angle diffusion obtained using the Tsyganenko models are enhanced at all resonant pitch angles for 200 eV electrons. In contrast, for 500 eV to 10 keV electrons the rates of pitch angle scattering are enhanced at intermediate and/or high pitch angles but tend to be considerably lower near the loss cone, thus reducing the precipitation loss compared to that in a dipole field. Upper band chorus acts as the dominant cause for scattering loss of 200 eV to 2 keV electrons, while lower band chorus scattering prevails for 5–10 keV electrons, consistent with the results using the dipole model. The first-order cyclotron resonance and the Landau resonance are mainly responsible for the net scattering rates of plasma sheet electrons by oblique chorus waves and also primarily account for the differences in bounce-averaged diffusion coefficients introduced by the use of Tsyganenko models. As the geomagnetic activity increases, the differences in scattering rates compared to the dipole results increase accordingly. Nonnegligible differences also occur particularly at high pitch angles for the diffusion rates between the Tsyganenko models, showing an increase with geomagnetic activity level and a dependence on the discrepancy between the Tsyganenko model fields. The strong dependence of bounce-averaged quasi-linear scattering rates on the adopted global magnetic field model and geomagnetic activity level demonstrates that realistic magnetic field models should be incorporated into future modeling efforts to accurately quantify the role of magnetospheric chorus in driving the diffuse auroral precipitation and the formation of electron pancake distributions.
Comparison of the Electrodialysis Performance in Tartrate Stabilization of a Red Wine Using Aliphatic and Aromatic Commercial and Modified Ion-Exchange Membranes

The application of electrodialysis for tartrate stabilization and reagent-free acidity correction of wine and juices is attracting increasing interest. New aliphatic membranes CJMC-3 and CJMA-3 and aromatic membranes CSE and ASE were tested to determine their suitability for use in these electrodialysis processes and to evaluate the fouling of these membranes by wine components for a short (6–8 h) operating time. Using IR spectroscopy, optical indication and measurement of surface contact angles, the chemical composition of the studied membranes, as well as some details about their fouling by wine components, was clarified. The current–voltage charsacteristics, conductivity and water-splitting capacity of the membranes before and after electrodialysis were analyzed. We found that in the case of cation-exchange membranes, complexes of anthocyanins with metal ions penetrate into the bulk (CJMC-3) or are localized on the surface (CSE), depending on the degree of crosslinking of the polymer matrix. Adsorption of wine components by the surface of anion-exchange membranes CJMA-3 and ASE causes an increase in water splitting. Despite fouling under identical conditions of electrodialysis, membrane pair CJMC-3 and CJMA-3 provided 18 ± 1 tartrate recovery with 31 · 10−3 energy consumption, whereas CSE and ASE provided 20 ± 1% tartrate recovery with an energy consumption of 28 · 10−3 Wh, in addition to reducing the conductivity of wine by 20 ± 1%. The casting of aliphatic polyelectrolyte films on the surface of aromatic membranes reduces fouling with a relatively small increase in energy consumption and approximately the same degree of tartrate recovery compared to pristine CSE and ASE.
Interactions among breed, farm intensiveness and cow productivity on predicted enteric methane emissions at the population level

Abstract The milk Fourier-transform infra-red spectrometry (FTIRS) can be used to predict the enteric methane emissions (EME) at population level. In this study, the variability in FTIRS predicted EME traits due to the breed of cow, farm, the production level of individual cows within herds, and their interactions were evaluated. A dataset obtained from milk recordings, which covered four breeds (Holstein, Brown Swiss, Simmental and Alpine Grey), 6,430 herds, 115,819 cows, and 1,759,706 test-day milk/spectra records was used. The herds were stratified into 5 production levels considering their average daily milk energy production; individual cows within herd were similarly stratified considering their individual production levels. The EME traits were predicted directly from milk FTIR spectra or indirectly from six informative milk FA predicted from milk spectra. The statistical model included, separately for each trait and method, breed, herd intensiveness level, cow production level, and their interactions, year, month, parity, and lactation stage. The direct and indirect methods yielded similar results in predicting CH4 yield per kg of DMI and CH4 intensity per kg of fat-protein corrected milk. The indirect method was reliable in predicting daily EME production per cow, the indirect one did not. EME was affected by the breed x herd production intensiveness interaction, and to a lesser degree, by the breed x cow production level interaction. A better understanding of the complex interactions influencing EME in dairy herds was achieved. This would be useful for the genetic improvement, the environmental certification of farms, and for setting prices in milk payment schemes. HIGHLIGHTS Causes of variation of the FTIR predicted EME were studied at population level using data from 6,430 herds and 1,759,706 milk spectra records Reliable daily EME estimates were achieved from 6 six informative fatty acids predicted from milk spectra EME was influenced by the interaction breed × level of herd intensiveness and, to a lesser extent, by the individual production level
Fintech, Bigtech Credit and Economic Growth: A Bibliometric Review and Meta Analysis

The financial sector plays a vital role to improve economic performance. Development of innovative lending strategies is necessary since debt is the largest form of finance. FinTech and BigTech credit are such innovative ways in the new era of extreme technological advancements that help ensure the economy is inclusive and grows in a sustainable manner. This paper applies a bibliometric review and meta-analysis by utilizing the SCOPUS database to explore the academic research that has been conducted on FinTech/BigTech credit and economic growth. The VOSviewer software was utilized to construct and visualize the bibliometric networks from the extracted data. Our findings show a massive increase in documents published on this topic between 2019 and 2022. Bank concentration, bank minimum capital requirements, market inefficiencies, financial inclusion and regulation on technological innovation were identified as key factors to influence FinTech/BigTech credit adoption. The significance of the study is that we identify the research gaps from previous studies and demonstrate the importance of establishing the nexus between FinTech/BigTech credit and economic growth.
GaN nanowire ultraviolet photodetector with a graphene transparent contact

We report on the fabrication of graphene contact to GaN nanowire ensemble and on the demonstration of photodetectors using chemical vapor deposition-grown few-layered graphene as a transparent electrode. The optimization of the transfer method allowed to form a continuous contact to the nanowires over a large area. The adhesion energy of the graphene sheet to the nanowire ensemble is estimated to be 0.3–0.7 J/m2. Ultraviolet photodetectors with a room-temperature responsivity of ∼25 A/W at 357 nm were fabricated. The photocurrent spectrum shows that the device has a strong response up to 4.15 eV confirming a good transparency of the top graphene contact.
Trapping in high-order orbital resonances and inclination excitation in extrasolar systems

Exoplanetary systems in mean motion resonance (MMR) are thought to have been captured as a result of gas-induced (Type II) orbital migration, during their early evolution phases. Using three-dimensional numerical simulations, Thommes & Lissauer showed that resonant inclination excitation can occur, for a system of two planets that evolves into a 2/1 MMR by Type II migration. In this paper, we examine whether capture in higher order resonances can also result in inclination excitation. We undertake a parametric study, varying the masses and orbital parameters of the planets, as well as the migration rate and eccentricity damping rate. We show that captures in high-order resonances (such as the 3/1, 4/1 and 5/1) are also able to produce inclination excitation. The maximal mutual inclination between the two orbital planes reaches values between 20° and 70° during a simulation, depending on the masses of the planets. Inclination excitation is observed for all configurations as long as (i) the inner planet is not very massive and (ii) at least one of the planets develops an eccentricity e > 0.4. Thus, our simulations imply that inclination excitation is a common outcome, as long as eccentricity damping is not too strong. On the other hand, our results suggest that planets in the exosystems HD 60532 (3/1 MMR), HD 108874 (4/1 MMR) and HD 102272 (4/1 MMR) are most probably in coplanar orbits, since they do not meet the above two constraints. Indeed, this result was verified by a series of dedicated numerical simulations.
Impedimetric Bacterial Detection Using Random Antimicrobial Peptide Mixtures

The biosensing of bacterial pathogens is of a high priority. Electrochemical biosensors are an important future tool for rapid bacteria detection. A monolayer of bacterial-binding peptides can serve as a recognition layer in such detection devices. Here, we explore the potential of random peptide mixtures (RPMs) composed of phenylalanine and lysine in random sequences and of controlled length, to form a monolayer that can be utilized for sensing. RPMs were found to assemble in a thin and diluted layer that attracts various bacteria. Faradaic electrochemical impedance spectroscopy was used with modified gold electrodes to measure the charge-transfer resistance (RCT) caused due to the binding of bacteria to RPMs. Pseudomonas aeruginosa was found to cause the most prominent increase in RCT compared to other model bacteria. We show that the combination of highly accessible antimicrobial RPMs and electrochemical analysis can be used to generate a new promising line of bacterial biosensors.
Reconciling Individual and Aggregate Evidence Concerning Partisan Stability: Applying Time-Series Models to Panel Survey Data

Party identification has been studied extensively using both individual- and aggregate-level data. This paper attempts to formulate a statistical model that can account for the range of empirical generalizations that have emerged from aggregate time series and panel surveys. Using Monte Carlo simulation, we show that only certain types of data generation processes can account for these empirical regularities. Deciding which of the remaining types best explains the data means investigating the ways in which individual-level partisanship behaves over time. Partisanship at the aggregate-level tends to be highly autocorrelated, reequilibrating slowly in the wake of each perturbation. Working downward from the analysis of aggregate data, previous researchers argued that aggregate partisanship is fractionally integrated and contended that dynamics at the individual level are therefore heterogeneous. Using data from three panel surveys, we present the first direct assessment of individual-level dynamics. We also investigate the hypothesis that these dynamics vary among individuals, a claim that motivates much recent work on fractionally integrated time series. The model that best explains the observed characteristics of party identification is one in which individuals respond in similar ways to external shocks, reequilibrate rapidly thereafter, and seldom change their equilibrium level of partisan attachment.
INSTITUTIONAL ADOPTION AND IMPLEMENTATION OF BLENDED LEARNING: DIFFERENCES IN STUDENT PERCEPTIONS

Blended learning (BL) has been a popular mode of course delivery in higher education, aiming to provide students with better learning experiences by integrating face-to-face (f2f) instructions and affordances of digital technology. However, lack of knowledge about how students perceive BL cross-disciplines can make it difficult for teachers to provide consistent learning experiences to students, yielding inequity in learning experiences. This study aims to explore how university students perceive BL, and to compare differences in perceptions across subjects. Participants were 407 university students from eight subject disciplines. Data were collected through a questionnaire and were analysed using SPSS. A one-way ANOVA was performed to compare the differences between the groups. Results showed, students were generally happy about use of BL, despite facing multiple barriers in using the learning approach. Results further revealed, students studying tourism/hospitality, and business subjects were more negative about BL, while students in science and engineering, and Islamic studies faculties were more receptive to BL compared to the rest of the university. Implications for adoption and implantation of BL, and teacher support are discussed.