Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of K-RAS mutations and CA125 tumor marker in patients with ovarian carcinoma

Background: Ovarian carcinoma is one of the leading causes of cancer-related death among females. K-ras codon 12 mutations are commonly occurring mutations in different types of cancers and leads to resistance against anti-EGFR therapeutics. Hence, determination of mutations in k-ras gene is crucial for predicting response to anti-EGFR therapies. This study aimed to evaluate the prevalence of k-ras gene mutations and CA125 tumor marker in patients with ovarian carcinoma in Tabriz city. Methods: Genomic DNA was extracted from 67 tissues pertained to women with ovarian carcinoma. Mutations in codon 12 and 13 of k-ras gene were analyzed by Nested PCR and RFLP methods. Titer of CA125 tumor marker was determined by ELISA. Results: Among the 67 patients, 7 patients (10.4%) had mutation in k-ras codon 12 while none of them had mutation in k-ras codon 13. Based on the results, the frequency of various genotypes were 89.55%, 10.44%, and 0%, for GG, GA, and AA alleles, respectively. The p-value for stage I and Grade I tumors were 0.022 and 0.04, respectively, indicating a statistically significant correlation between codon 12 mutation and stage I and Grade I tumors. Furthermore, we found significant correlations among CA125 tumor marker titers and histological grade (p<0.000) and stage (p<0.000). The mean serum CA125 tumor marker levels in malignant carcinomas were 499.84 U/ml. Conclusion: The results in this study indicated high prevalence of k-ras codon 12 mutations and high titer of CA125 tumor marker in patients with ovarian carcinoma in the study region.
THE ROLE AND FUNCTIONING OF BUSINESS GROUPS

We compare group affiliation in seven East Asian countries and Chile, using data for more than 1,000 publicly traded firms. We document that 75 percent of listed firms in our East Asia sample are associated with business groups, but only 40 percent in Chile. We find evidence that group structures are used to diversify risks internally as firms’ market risk is influenced not only by own characteristics-such as size, price/book ratio-but also by group characteristics, especially in Chile. There are costs to groups, however. For East Asian countries, we find that group structures are used by controlling owners to expropriate other shareholders. On balance, it appears that business groups are not beneficial to shareholders.
Microbiological Quality and Safety of Raw Milk Collected from Kersa District, Jimma Zone, Southwest Ethiopia

The safety of milk with respect to food-borne pathogens is a great concern worldwide. Therefore, this study was to assess the microbiological quality and safety of raw cow’s milk of individual farmers and dairy farms in Kersa district. Microbial analysis of the milk was analyzed for a total of 100 samples following standard procedures. The hygienic quality of raw milk was poor with an overall mean total bacterial count, coliform count, lactic acid bacteria, staphylococci, yeasts and mould counts of 8.48, 5.82, 4.53, 5.23, 4.8, 4.35 log CFU/ml, respectively. The percent lactic acid and pH of the samples were 0.26 and 6.27, respectively. There were significant difference (P < 0.05) among mean counts of microbes except between mean counts of staphylococci and coliforms. The bacterial groups isolated from raw milk were Staphylococcus spp. , Streptococcus spp. , Enterobacteriaceae, Micrococcus spp. , Pseudomonas spp. , Bacillus spp. Lactobacillus spp. , Leuconostoc spp. and Aeromonas spp. The samples of both farm groups were dominated by Lactobacillus followed by Staphylococcus spp. and Streptococcus spp. Among pathogenic bacteria of public health significance, S. aureus and Salmonella spp. were also detected in 34 (34%) and 20 (20%) samples, respectively. S. aureus isolates were showed the highest resistance to Methicillin (100%) and Penicillin G (91.2%). Likewise, Salmonella isolates were most highly resistance to Nalidixic acid (80%). Thus, hygienic quality of raw cow’s milk was poor which may cause a potential health risk and therefore hygienic safety measure should be taken.
The effect of using a program depending on argument based inquiry approach via “write- to- learn strategy” on 8th grade students’ abilities of forming scientific mental models

The Purpose of this study is to investigate the effect of using a program depending on argument based inquiry approach via “writetolearn strategy” on 8th grade students’ abilities of forming scientific mental models. As well as the effect of the interaction between argument based inquiry approach via write to learn strategy method of teaching, and gender on 8th grade students’ abilities of forming scientific mental models. The study was conducted on a purposive sample of 8th grade students (females and males) enrolled at public schools in Jerusalem district. The schools are: Bethany Secondary School for Girls and Al Ma’ahad Al Arabi School for Boys during the second semester of the academic year 2016\2017. The Sample consisted of 152 students of the 8th grade (71 females and 81 males). Students from both schools were assigned to experimental and control group randomly. The experimental group was taught a whole unit by the argument based inquiry approach via “write-to-learn strategy”, while the control group was taught by the traditional method. The experiment lasted for two months. The researcher has prepared an instrument for the study, Self Mental Model Exam. Content validity and reliability was done for it. A pre and post test was done for all of the participants to measure the effect of using a program depending on argument based inquiry approach via “writetolearn strategy” on 8th grade students’ abilities of forming scientific mental models. The means, standard deviations, and (1-way ANCOVA) test were used in the study. The findings of the study showed that there are statistically significant differences at (α≤ 0.05) in the mean scores of 8th grade students’ abilities to form mental models due to method of teaching in favor of the experimental group, there are statistically significant differences at (α≤ 0.05) in the mean scores of 8th grade students’ abilities to form mental models due to gender in favor of males and there are statistically significant differences at (α≤ 0.05) in the mean scores of 8th grade students’ abilities to form mental models due to the interaction between method of teaching and gender in favor of males in the experimental group. In the light of these results the researcher recommends using the argumentation via “write-to-learn strategy” in teaching science due to its effect in improving students’ skills.
Voice Onset Times of Voiceless Stops by Bilingual Korean-English Children: Phonetic Acquisition and Sociolinguistic Preferences

The acquisition of native-like accent in a second language (L2) depends on the acquisition of a number of phonological features. In particular, the acquisition of voice onset time (VOT) may be particularly challenging, with phonemic distinctions being made in some languages by minimal changes in VOT length (Cho & Ladefoged, 1999). Numerous studies of adult bilinguals indicate that attainment of native-like L2 VOT may not be possible (Flege, 1984, 1986, 1995; Flege & Hillenbrand, 1986). Instead, an intermediary VOT is acquired, sometimes even expressed across both languages the bilingual speaks. On the other hand, child bilinguals, particularly younger children, can acquire native-like L2 VOTs, with age of acquisition affecting their likelihood of attaining native-like VOT production. VOTs are also of interest for their sociophonetic variation, which allows speakers to demonstrate cultural membership and affiliation. Following attainment of these features, language learners are able to employ culturally associated sociophonetic variation as well. This study considers both the phonetic acquisition and sociophonetic variation of VOTs by 11 y.o. Korean-English bilingual children who have had 2 years of immersive L2 English exposure. *
Outcomes of Cranioplasty Using Autologous Bone or 3D-Customized Titanium Mesh Following Decompressive Craniectomy for Traumatic Brain Injury: Differences in Complications

eISSN 2287-1683 pISSN 1738-8767 Copyright © 2019 The Korean Society of Trauma This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. outcomes of Cranioplasty using autologous Bone or 3d-Customized Titanium mesh following decompressive Craniectomy for Traumatic Brain Injury: differences in Complications
Does CEO Turnover Matter? Empirical Evidence from the Philippines

This study investigated the market reaction to announcements of CEO turnovers in Philippine-listed companies between January 2008 and December 2018. Turnovers were classified concerning successors’ origin (internal versus external), turnover type (forced versus voluntary), and successors’ gender (male versus female). Event study methodology using the market model was employed to analyze the hand-collected sample of 136 CEO turnover announcements. Market reaction was significantly positive for internal, external, and voluntary turnover. The market reaction, however, was found to be significantly negative in the case of forced turnover. Similarly, concerning the gender difference, the result showed that market reaction was significantly negative for female CEO appointments and significantly positive for male CEOs. The results provide strong evidence that new CEOs’ selected attributes and the turnover’s characteristics are factors that have the explanatory power on the investor’s reaction. The contributions of this study to the literature are threefold. First, it serves as the first empirical evidence of market reaction to CEO turnover from the Philippines emerging market. This study also confirms the finding of the previous studies on CEO turnover by looking into several turnover categories, namely external, internal, forced, and voluntary. Finally, it enriches the limited empirical evidence on the CEOs’ gender effect on abnormal return surrounding the turnover announcement date.
Bioremediation of Phenol by Mutated and Immobilized Aspergillus and Penicillium Species

Phenol and its chemical derivatives are essential for production of polycarbonates epoxies, bakelite, nylon, detergents, herbicides, and numerous pharmaceutical drugs. In order to increase the biodegradation of phenol by fungi, fungal strains (Aspergillus niger, Penicillium griseofulvum and Aspergillus terreus), were isolated from different contaminated sites in Saudi Arabia such as Jeddah Governate, the second industrial city of Jeddah, some garbage collection places, gas stations and Red Sea), then screened for phenol degradation. For the first time in Saudi Arabia, biodegradation of phenol by fungi is improved by mutation as well as immobilization of fungi above calcium alginate. The isolated fungal strains (Aspergillus niger, Penicillium griseofulvum and Aspergillus terreus), were mutated physically (UV) and chemically (Ethidium bromide), also immobilized in alginate beads and its phenol degradation efficiency was observed. The degradation was increased many fold after immobilization, but after mutation some mutants appeared highly degradation rate for the phenol such as Aspergillus niger, and Penicillium griseofulvum but Aspergillus terreus appeared highly degradation rate for the phenol only after exposure to UV for 5 and 10 mins only than the wild strains. In addition, phenol degradation was increased with increase the fungal disk size of the tested strains.
Use of real time polymerase chain reaction (PCR) and histopathological changes for detection of the Toxoplasma gondii parasite in male rats (experimental study)

Toxoplasma gondii infection is wide spread in Iraq that is why this study was carried out to detect its presence in semen samples of infected male rats experimentally. Impression smears, real time polymerase chain reaction (PCR) and histopathological changes were used for detection of T. gondii. The current study included the isolation of local strains of T. gondii from placenta of women that experienced abortion that had toxoplasmosis history, 0.3 ml of suspension contained 100 tissue cyst per rat injected interperetonially in 40 rats. Eight weeks post inoculation, rats were sacrificed then dissected and epididymis was immediately removed. Impression smear were made from semen stained with eosin-nigrosin as initial diagnosis of infection confirmed by the presence of cysts of parasite. This confirmation is dependent on the molecular diagnosis by real time PCR which successfully detected the parasite in 90.3% of rats inoculated with aborted placenta suspension. Some histological changes in testicular tissue were collapse and shrinkage in somniferous tubules with multinucleated giant cells with vacuolar degeneration of lydig cell. These finding suggest that T. gondii infection cause a temporary impairment and insufficiency in male reproductive activity with probability of transmission of the parasite in semen to females or to other animals such as cats. Key words: Testes, placenta, semen, real time polymerase chain reaction (PCR), impression, interperitonially, reproductive, male.
Writing Argumentative Essay: How Far They Can Go?

Writing is very important for everyone to share their ideas, experiences and their thoughts into the written form. This present study tries to figure out and explore the university students in writing argumentative essay. Therefore, this present conducted a survey research to 21 students who produced 21 argumentative essay from English department in Universitas Lancang Kuning. The survey analysed the Content, Organization, Vocabulary, Grammar, Mechanics In order to answer the research question. The result of the research showed that the students’ ability in argumentative essay was good regarding on the result of the test. This analysis of this present study found that the students’ ability in argumentative essay was categorised in very good level (96,55). This is means that these 21 students can go further on their academic journey regarding English when it needs an argumentative essay in written form.
Solubility and Dissolution Enhancement of Atorvastatin Calcium using Solid Dispersion Adsorbate Technique

Atorvastatin (ATR) is poorly soluble anti-hyperlipidemic drug; it belongs to the class II group according to the biopharmaceutical classification system (BCS) with low bioavailability due to its low solubility. Solid dispersions adsorbate is an effective technique for enhancing the solubility and dissolution of poorly soluble drugs. The present study aims to enhance the solubility and dissolution rate of ATR using solid dispersion adsorption technique in comparison with ordinary solid dispersion. polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000), Poloxamer188 and Poloxamer 407were used as hydrophilic carriers and Aerosil 200, Aerosil 300 and magnesium aluminium silicate (MAS) as adsorbents. All solid dispersion adsorbate (SDA) formulas were prepared in ratios of 1:1:1 (drug: carrier: adsorbent) and evaluated for their water solubility, percentage yield, drug content, , dissolution, crystal structure using X-ray powder diffraction (XRD) and Differential Scanning Calorimetry (DSC) studies and Fourier Transform Infrared Spectroscopy (FTIR) for determination the drug-carrier- adsorbate interaction. The prepared (SDA) showed significant improvement of drug solubility in all prepared formula. Best result was obtained with formula SDA12(ATR :Poloxamer407 : MAS 1:1:1) that showed 8.07 and 5.38 fold increase in solubility compared to solubility of pure ATR and solid dispersion(SD4) (Atorvastatin: Poloxamer 407 1:1) respectively due to increased wettability and reduced crystallinity of the drug which leads to improve drug solubility and dissolution .
Adoption and Implementation of Enterprise Resource Planning (ERP): An Empirical Study

The study is an attempt to unearth the current state of Enterprise Resource Planning (ERP) adoption and implementation in both manufacturing and service firms. Drawing on the conceptualization of multiple theories based in technology acceptance and innovation diffusion model, this study examines the above objectives with a particular reference to the Unified Theory of Acceptance and Use of Technology (UTAUT). Following the deductive reasoning approach, we applied a self-administered questionnaire survey and used 235 replies from 255 collected responses, leaving the data affected with missing and un-matched responses. The result is applied using the structural equation modeling via SmartPLS 2, a second generation regression model, for testing hypothesized relationships. Findings reveal that all the hypothesized influences are found significantly linked through the explanatory variables with the endogenous variables at different levels of significance, except the impact of effort efficiency and resistance to change. Policy implications are also proposed for the full adoption and utilization of ERP to achieve sustainable development goals. Furthermore, we recommend future researchers to focus on action research or experimental data for preventing the generalizability of the observed results.
INHERITANCE OF SOME IMPORTANT TRAITS IN SWEET PEPPER (Capsicum annuum L.)

The present study was conducted at the Experimental Farm, Faculty of Environmental Agricultural Sciences, El Arish, Suez Canal University, Egypt, during three successive summer seasons from 2011 to 2013. The study involved six generations; viz., P1, P2, F1, F2, Bc1 and Bc2 of sweet pepper hybrid (B10-24 x TS 6-3-3). The objective of the present investigation was to study the inheritance of some important traits of sweet pepper. The obtained results showed that difference between the two parents was highly significant for all studied traits. The means of F1 cross was deviated toward the high parent for most characters, while it was similar to that of high parent for average fruit weight. Segregating populations showed greater coefficient of variability (C.V%) than the non-segregating ones for all studied traits. Additive gene effects (d) were significant in the inheritance of all characters, except fruit length, fruit diameter and pericarp thickness. However, dominance gene action (h) was more importance in the inheritance of all studied traits, except number of fruits/plant. Epistasis gene actions were found to be important in the inheritance of most traits. Heterosis over mid-parents was detected in eight characters. However, heterosis over better parent was found, but only in three traits. Inbreeding depression was observed in six characters. Heritability estimates in broad sense (hb) were high for all characters. The minimum number of genes controlling the traits were one pair for plant height, fruit diameter, pericarp thickness, T.S. S, ascorbic acid and total yield/plant, while number of genes were estimated as two to three pairs for number of branches, two to four for fruit length, three to seven for number of fruits/plant and two pairs for average fruit weight.
Risk factors and survival of patients with permanent pacemaker implantation after heart transplantation.

Background Permanent pacemaker (PPM) implantation after heart transplantation (HTX) may be required due to severe bradycardia. The aim of this study was to investigate the risk factors, indications, perioperative outcomes and complications of PPM implantation after HTX as well as the underlying effect on post-transplant mortality including causes of death. Methods This registry study included 621 patients receiving HTX at Heidelberg Heart Center between 1989 and 2018. Patients were stratified by PPM implantation after HTX. Data analysis of risk factors for PPM implantation included donor and recipient demographics, post-transplant medication, mortality, and causes of death. Results Thirty-six patients (5.8%) received PPM implantation after HTX, 12 (33.3%) with early PPM and 24 (66.7%) with late PPM. Indications for PPM implantation after HTX included sinus node dysfunction (SND) (n=15; 41.7%) and atrioventricular block (AVB) (n=21; 58.3%). Multivariate analysis revealed recipient body mass index (BMI) [hazard ratio (HR): 1.10; confidence interval (CI): 1.01-1.21; P=0.03], donor age (HR: 1.07; CI: 1.03-1.10; P<0.01), and biatrial HTX (HR: 2.63; CI: 1.22-5.68; P=0.01) as significant risk factors for PPM implantation after HTX. Kaplan-Meier estimator displayed a statistically significant inferior 5-year post-transplant survival among patients with early PPM after HTX in comparison to patients with late PPM or no PPM after HTX (P<0.01) along with a higher percentage of death due to infection (P<0.01). Conclusions Multivariate risk factors for PPM implantation after HTX include recipient BMI, donor age, and biatrial HTX. Early PPM implantation after HTX is associated with increased 5-year post-transplant mortality due to infection.
Exposure to toxic fescue during late gestation on beef cows: effects on cow performance and offspring performance from birth to weaning

To examine the effects of endophyte-infected tall fescue during late gestation on maternal and offspring performance, multiparous Angus cows (n = 40) were bred via AI and allocated into grazing treatments: toxic (E+) or nontoxic (E-) endophyte tall fescue. Cows body weight (BW), body temperature, body condition score (BCS), and respiration rate were recorded and blood samples collected on 180, 210 and 240 days of gestation. Calf’s BW were recorded at birth and weaning. Cow/calf pairs were managed as one group on nontoxic pasture from calving until weaning (180 days of age). Body weight decreased (P = 0.022) and body temperature increased (P < 0.0001) at day 240 in E+ compared to Ecows. BCS did not differ (P = 0.891) between treatments. Respiratory frequency increased (P = 0.003) in E+ compared to Ecows. Ergovaline concentration of urine increased (P = 0.003) at day 210 and 240 in E+ compared to Ecows. Prolactin concentrations decreased (P < 0.0001) at day 210 in E+ compared to Ecows. Birth and weaning weight decreased (P < 0.05) in calves from E+ cows compared to Ecows. Overall, grazing endophyte-infected tall fescue reduced maternal and subsequent offspring BW.