Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of serum interleukin‐1 receptor antagonist levels in major depressive disorder: A case‐control study

Major depressive disorder (MDD) is characterized by the occurrence of one or more depressive episodes lasting a minimum of 2 weeks and is marked by a persistently low mood and a lack of enjoyment in daily activities. The diagnosis of MDD is not possible by a well‐established laboratory test or biomarker. A wide range of potential biomarkers for depression have been proposed by many studies, but none of them has adequately described the correlation between the biomarkers and depression. The purpose of this study was to evaluate serum interleukin‐1 receptor antagonist (IL‐1RA) levels as an early depression risk factor.
Algebraic design techniques for reliable stabilization

In this paper we study two problems in feedback stabilization. The first is the simultaneous stabilization problem, which can be stated as follows. Given plants G_{0}, G_{1},. , G_{l} , does there exist a single compensator C that stabilizes all of them? The second is that of stabilization by a stable compensator, or more generally, a "least unstable" compensator. Given a plant G , we would like to know whether or not there exists a stable compensator C that stabilizes G ; if not, what is the smallest number of right half-place poles (counted according to their McMillan degree) that any stabilizing compensator must have? We show that the two problems are equivalent in the following sense. The problem of simultaneously stabilizing l + 1 plants can be reduced to the problem of simultaneously stabilizing l plants using a stable compensator, which in turn can be stated as the following purely algebraic problem. Given 2l matrices A_{1}, . , A_{l}, B_{1}, . , B_{l} , where A_{i}, B_{i} are right-coprime for all i , does there exist a matrix M such that A_{i} + MB_{i} , is unimodular for all i? Conversely, the problem of simultaneously stabilizing l plants using a stable compensator can be formulated as one of simultaneously stabilizing l + 1 plants. The problem of determining whether or not there exists an M such that A + BM is unimodular, given a right-coprime pair ( A, B ), turns out to be a special case of a question concerning a matrix division algorithm in a proper Euclidean domain. We give an answer to this question, and we believe this result might be of some independent interest. We show that, given two n \times m plants G_{0} and G_{1} we can generically stabilize them simultaneously provided either n or m is greater than one. In contrast, simultaneous stabilizability, of two single-input-single-output plants, g 0 and g 1 , is not generic.
Safety and efficacy of a feed additive consisting of pancreatin from porcine pancreas (Pan‐zoot) for dogs (Almapharm GmbH + Co KG)

Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a pancreatic extract (Pan‐zoot) as a zootechnical additive for dogs. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the safety of Pan‐Zoot as a feed additive for dogs under the proposed conditions of use. The FEEDAP Panel could not conclude on the skin/eye irritancy potential of the additive or on the dermal sensitisation potential. Owing to its proteinaceous nature, the additive is considered a respiratory sensitiser. The additive may induce allergic reactions to the exposed users. The Panel concluded that there is no need for an environmental risk assessment. The FEEDAP Panel could not conclude on the efficacy of the product as a feed additive at the recommended conditions of use.
Bilateral antrochoanal polyp: a case report of an extremely rare entity managed conservatively with a review from the past 26 years

Introduction and importance: Antrochoanal polyp (ACP) is a well-known benign sinonasal polyp first described in the early 20th century. ACP mostly presents as a unilateral mass and is treated solely with surgical excision. Case presentation: We report a rare case of a middle-aged man presenting with nasal obstruction, rhinorrhea, and sleeping disturbances, eventually diagnosed with bilateral ACPs. After confirming the diagnosis with imaging and biopsy studies, the patient was treated conservatively, with marked improvements in his symptoms during 2–3 months of regular follow-ups. A review of the relevant literature regarding the presentation, diagnosis, and outcome of this rare entity is presented, highlighting its controversial etiopathogenesis. Clinical discussion: Presenting symptoms of ACP in most cases is unilateral progressive nasal obstruction. The occurrence of ACP bilaterally is rarely encountered in clinical practice. Diagnosis is mainly clinical and is achievable via nasal endoscopic examination and supported by computed tomography imaging. Treatment remains to be surgical, with 2 years of regular follow-ups being advised to detect any recurrence. Conclusion: This case report adds to the scarce data pool on bilateral ACPs and highlights the necessity of prudent and timely diagnosis of this uncommon entity to avoid unnecessary investigations and lengthy medical or surgical treatment. Additionally, a trial of medical therapy may provide symptomatic relief for patients who do not qualify for surgery.
Asymptotic Completeness in Quantum Field Theory. A Class of Galilei-Covariant Models

0. Introduction 192 1. General Definitions 195 1.1. Hilbert spaces 195 1.2. Homomorphisms of commutative C∗and W ∗-algebras 196 1.3. Permutations 197 1.4. Clusters 197 1.5. Cartesian and tensor products associated with a cluster 198 1.6. Clusterings 198 1.7. Cartesian and tensor products associated with a clustering 199 2. Distinguishable Particles 199 2.1. Elementary particles 199 2.2. Clusters of elementary particles 199 2.3. Asymptotic particles 201 2.4. Clusters of asymptotic particles 201 2.5. Identification operator 202 2.6. Existence of the asymptotic velocity 202 2.7. Short-range case 202 2.8. Long-range case – free region 203 2.9. Long-range case – asymptotic interacting Hamiltonian 204 2.10. Long-range case – modified wave operators 205 3. Second Quantization in the Category of Sets 206 3.1. Second quantization of a set 206 3.2. “Third quantization” of a set 207 3.3. Permutations that preserve species 207 3.4. Clusters with composition n ∈ Γ(E) 208 3.5. Permutations that preserve species and a clustering 208 3.6. Clusterings associated with k ∈ Γ(E) 210 3.7. Identification operators 210 4. Second Quantization in the Category of Z2-Hilbert Spaces 211 4.1. Fock spaces 211
Diagnostic Value of Transbronchial Lung Cryobiopsy Using an Ultrathin Cryoprobe and Guide Sheath for Peripheral Pulmonary Lesions

Background: The addition of cryobiopsy to conventional biopsy methods improves the diagnostic yield of peripheral pulmonary lesions. Moreover, cryobiopsy with a guide sheath (GS) provides additional diagnostic benefits. Semi-real-time biopsy can be repeatedly performed using conventional biopsy devices and a GS, and subsequent cryobiopsy can be easily performed at the same location. Recently, a disposable 1.1 mm-diameter ultrathin cryoprobe has been developed and can be used with a 1.95 mm GS in a 2.0 mm working channel. In this study, we evaluated the diagnostic performance of transbronchial lung cryobiopsy (TBLC) with the 1.1 mm cryoprobe and a GS in patients with peripheral pulmonary lesions. Methods: We retrospectively reviewed the medical records of patients who underwent endobronchial ultrasound transbronchial lung biopsy with a guide sheath and TBLC from July 23, 2021 to April 30, 2022 at Chungnam National University Hospital. Results: Of a consecutive series of 229 patients, 199 were included. The diagnostic yields of forceps biopsy and cryobiopsy were 65.3% (130/199) and 84.4% (168/199), respectively, and the total diagnostic yield was 91.5% (182/199) (P<0.001 vs. forceps biopsy). Multivariate analysis showed that solid lesion morphology [adjusted odds ratio (OR) 3.659, P=0.002] was associated with a significantly greater diagnostic yield of cryobiopsy, whereas a lesion diameter >20 mm (P=0.026; adjusted OR 3.816) and ‘within’ orientation (P=0.004; adjusted OR 6.174) were associated with a significantly greater overall diagnostic yield. Conclusion: TBLC using an ultrathin cryoprobe and GS markedly improves the diagnostic yield.
Whole-exome screening for primary congenital glaucoma in Lebanon

ABSTRACT Purpose Mutations were previously identified in the CYP1B1 gene in six out of 18 Lebanese families (33%) with primary congenital glaucoma (PCG). The purpose of this study is to determine the frequency and type of pathogenic mutations in other genes and compare to other populations using whole-exome sequencing and perform genotype–phenotype correlations. Methods Twelve PCG patients previously negative for CYP1B1/MYOC mutations were subjected to whole-exome sequencing. Targeted screening for glaucoma-associated genes was performed. Candidate variants were verified by Sanger sequencing and evaluated in family members for segregation analysis and in 100 normal controls. Clinical correlations were established as to severity of disease presentation, course, and visual outcomes. Results Six mutations in known PCG-causing genes were identified in five patients: homozygous mutations in CYP1B1 (p.R368G), LTBP2 (p.E1013G), and TEK (p.T693I), and heterozygous mutations in FOXC1 (p.Q92*), TEK (c.3201-1 G>A), ANGPT1 (p.K186N), and CYP1B1 (p.R368G). Two patients, negative for CYP1B1 in the previous study, were revealed positive in the current study, due to different sets of primers and PCR conditions. Potentially damaging variants were noted in several candidate genes. Except for FOXC1 mutations, all genetic variants described here are novel. Intra-ocular pressure and final optic nerve cup-to-disc ratio were highest in the patient with three mutations in LTBP2/TEK/ANGPT1 genes. Conclusion This study provides new data on the spectrum of mutations of PCG in Lebanon. This highlights the genetic heterogeneity of the Lebanese population, noted for high rates of consanguinity in 50% in this cohort. This study emphasizes the importance of whole-exome sequencing in elucidating new candidate genes for PCG in the Lebanese.
Attoliter fluid experiments in individual closed-end carbon nanotubes: Liquid film and fluid interface dynamics

A hydrothermal method of catalytic nanotube synthesis has been shown to produce high-aspect-ratio, multiwall, capped carbon nanotubes, which are hollow and contain a high-pressure encapsulated aqueous multicomponent fluid displaying clearly segregated liquid and gas by means of well-defined curved menisci. Thermal experiments are performed using electron irradiation as a means of heating the contents of individual nanotubes in the high vacuum of a transmission electron microscope (TEM). The experiments clearly demonstrate that TEM can be used to resolve fluid interface motion in nanochannels. Good wettability of the inner carbon walls by the water-based fluid is shown. Fully reversible interface dynamic phenomena are visualized, and an attempt is made to explain the origin of this fine-scale motion. Experimental evidence is presented of nanometer-scale liquid films rapidly moving fluid along the nanochannel walls with velocities 0.5 μm/s or higher.
Sex differences in resting-state functional networks in awake rats

Sex-related differences can be found in many brain disorders and psychophysiological traits, highlighting the importance to systematically understand the sex differences in brain function in humans and animal models. Despite emerging effort to address sex differences in behaviors and disease models in rodents, how brain-wide functional connectivity (FC) patterns differ between male and female rats remains largely unknown. Here we used resting-state functional magnetic resonance imaging (rsfMRI) to investigate regional and systems-level differences between female and male rats. Our data show that female rats display stronger hypothalamus connectivity, whereas male rats exhibit more prominent striatum-related connectivity. At the global scale, female rats demonstrate stronger segregation within the cortical and subcortical systems, while male rats display more prominent cortico-subcortical interactions, particularly between the cortex and striatum. Taken together, these data provide a comprehensive framework of sex differences in resting-state connectivity patterns in the awake rat brain, and offer a reference for studies aiming to reveal sex-related FC differences in different animal models of brain disorders.
Frame Contention between News Sources and News Media: Framing the Dispute of Teaching Mathematics and Science in English

The studies of framing have been so far focusing on the analysis of media effects or the frame-setting process. Comparatively, the process of building media frames that takes place in the newsrooms has received meagre attention from the scholars. And traditionally, most of the studies that investigate frame-building process have their attention centred on the internal factors, including newsroom practices and characteristics of the journalist. External factors, especially the interaction between media and news sources, are thus far being overlooked. On that account, this study seeks to examine the influences of the above two variables on frame-building process through examination of a contemporary issue in Malaysia – teaching Mathematics and Science in English. The scrutiny of the role of news sources in the process of frame-building may contribute significantly to the knowledge of framing studies. Based on the 1,156 units of analysis collected from five Malaysian Chinese dailies, the study’s findings show that news sources or frame sponsors are comparatively more influential in the frame-building process.
Impacts of anthropogenic climate change on tropical montane forests: an appraisal of the evidence

In spite of their small global area and restricted distributions, tropical montane forests (TMFs) are biodiversity hotspots and important ecosystem services providers, but are also highly vulnerable to climate change. To protect and preserve these ecosystems better, it is crucial to inform the design and implementation of conservation policies with the best available scientific evidence, and to identify knowledge gaps and future research needs. We conducted a systematic review and an appraisal of evidence quality to assess the impacts of climate change on TMFs. We identified several skews and shortcomings. Experimental study designs with controls and long‐term (≥10 years) data sets provide the most reliable evidence, but were rare and gave an incomplete understanding of climate change impacts on TMFs. Most studies were based on predictive modelling approaches, short‐term (<10 years) and cross‐sectional study designs. Although these methods provide moderate to circumstantial evidence, they can advance our understanding on climate change effects. Current evidence suggests that increasing temperatures and rising cloud levels have caused distributional shifts (mainly upslope) of montane biota, leading to alterations in biodiversity and ecological functions. Neotropical TMFs were the best studied, thus the knowledge derived there can serve as a proxy for climate change responses in under‐studied regions elsewhere. Most studies focused on vascular plants, birds, amphibians and insects, with other taxonomic groups poorly represented. Most ecological studies were conducted at species or community levels, with a marked paucity of genetic studies, limiting understanding of the adaptive capacity of TMF biota. We thus highlight the long‐term need to widen the methodological, thematic and geographical scope of studies on TMFs under climate change to address these uncertainties. In the short term, however, in‐depth research in well‐studied regions and advances in computer modelling approaches offer the most reliable sources of information for expeditious conservation action for these threatened forests.
Safety Assessment of Helianthus annuus (Sunflower)-Derived Ingredients as Used in Cosmetics

This is a review of the scientific literature and unpublished data that are relevant for assessing the safety of 12 Helianthus annuus (sunflower)-derived ingredients as used in cosmetics. Because final product formulations may contain multiple botanicals, each containing similar constituents of concern, formulators are advised to be aware of these constituents and to avoid levels that may be hazardous to consumers. Helianthus annuus (sunflower)-derived ingredients may contain allergens, including 2S albumins and sesquiterpene lactones. Industry should use current good manufacturing practices (cGMP) to limit impurities and constituents of concern. The Expert Panel for Cosmetic Ingredient Safety (Panel) concluded that 9 Helianthus annuus (sunflower) seed- and flower-derived ingredients are safe as used in cosmetics in the present practices of use and concentration described in this safety assessment. The data are insufficient to evaluate the safety of 3 ingredients that are derived from other plant parts.
Eating disorder risk among college sorority and fraternity members within the United States

ABSTRACT Eating disorder (ED) risk is elevated among college populations in the United States. However, current research assessing the relative risk of ED symptomatology within Greek life has been mixed. We aimed to assess whether Greek Life Affiliation (GA) was associated with a greater risk for ED among college students in the United States as measured on the SCOFF questionnaire. Data were extracted from the Healthy Minds Study, which surveyed 44,785 American college students across 79 schools. The survey asked about GA, Greek life housing, and included the SCOFF questionnaire. This study utilized multiple logistic regressions and chi-square analyses (n = 44785) to analyze the data. GA failed to predict ED-risk in both women (aOR = 0.98 [95% CI = 0.90, 1.06]) and men (aOR = 1.07 [95% CI = 0.92, 1.24]). Similarly, among female [aOR = 1.00 [95% CI = 0.46, 2.12]) and male participants (aOR = 1.06 [95% CI = 0.59, 1.98]), sorority/fraternity housing also failed to predict ED-risk. Greek Life Affiliation is not associated with greater ED-risk among US college students.
Plasma formation in holmium:YAG laser lithotripsy

During holmium:yttrium–aluminum–garnet (holmium:YAG) laser lithotripsy to break urinary stones, urologists frequently see flashes of light. As infrared laser pulses are invisible, what is the source of light? Here we studied the origin, characteristics, and some effects of flashes of light in laser lithotripsy.
Current advancements in pharmacotherapy for cancer cachexia

ABSTRACT Introduction Cancer cachexia is a multifactorial metabolic syndrome associated with a pathophysiology intertwined with increased inflammatory response, anorexia, metabolic dysregulation, insulin resistance, and hormonal alterations, which together generate a negative energy balance in favor of catabolism. The development of therapeutic strategies to treat cancer cachexia has always been related to clinical interventions with increased food intake/supplementation, physical exercise regimens, and/or medication to attenuate catabolism and increase the anabolic response. However, the approval of drugs by regulatory agencies has always been a challenge. Areas covered This review outlines the main pharmacotherapy findings in cancer cachexia as well as the ongoing clinical trials that have evaluated changes in body composition and muscle function. The National Library of Medicine (PubMed) was used as search tool. Expert opinion The pharmacological therapy for cachexia should be focused on improving body composition, muscle function, and mortality, although none of the compounds used so far was able to demonstrate positive results beyond increased appetite and improvements in body composition. Ponsegromab (GDF15 inhibitor), a new compound that has just entered a phase II clinical trial, is a promising candidate to treat cancer cachexia and may produce exciting results if the study can be conducted as planned.
Initial mean arterial blood pressure (MABP) measurement is a risk factor for mortality in hypertensive COVID-19 positive hospitalized patients

Background Hypertension (HTN) is associated with severe COVID-19 infection; however, it remains unknown if the level of blood pressure (BP) predicts mortality. We tested whether the initial BP in the emergency department of hospitalized patients portends mortality in COVID-19 positive(+) patients. Methods Data from COVID-19(+) and negative (-) hospitalized patients at Stony Brook University Hospital from March to July 2020 were included. The initial mean arterial BPs (MABPs) were categorized into tertiles (T) of MABP (65–85 [T1], 86–97 [T2] and ≥98 [T3] mmHg). Differences were evaluated using univariable (t-tests, chi-squared) tests. Multivariable (MV) logistic regression analyses were computed to assess links between MABP and mortality in hypertensive COVID-19 patients. Results 1549 adults were diagnosed with COVID-19 (+) and 2577 tested negative (-). Mortality of COVID-19(+) was 4.4-fold greater than COVID-19(-) patients. Though HTN prevalance did not differ between COVID-19 groups, the presenting systolic BP, diastolic BP, and MABP were lower in the COVID-19(+) vs (-) cohort. When subjects were categorized into tertiles of MABP, T2 tertile of MABP had the lowest mortality and the T1 tertile of MABP had greatest mortality compared to T2; however, no difference in mortality was noted across tertiles of MABP in COVID-19 (-). MV analysis of COVID-19 (+) subjects exposed death as a risk factor for T1 MABP. Next, the mortality of those with a historic diagnosis of hypertension or normotension were studied. On MV analysis, T1 MABP, gender, age, and first respiratory rate correlated with mortality while lymphocyte count inversely correlated with death in hypertensive COVID-19 (+) patients while neither T1 nor T3 categories of MABP predicted death in non-hypertensives. Conclusions Low-normal admitting MABP in COVID-19 (+) subjects with a historical diagnosis of HTN is associated with mortality and may assist in identifying those at greatest mortality risk.