Miracle-dz/UniFAR-FTUs huggingface dataset:
People with more extreme attitudes towards science have self-confidence in their understanding of science, even if this is not justified

People differ greatly in their attitudes towards well-evidenced science. What characterises this variation? Here, we consider this issue in the context of genetics and allied sciences. While most prior research has focused on the relationship between attitude to science and what people know about it, recent evidence suggests that individuals with strongly negative attitudes towards specific genetic technologies (genetic modification (GM) technology and vaccines) commonly do not objectively understand the science, but, importantly, believe that they do. Here, using data from a probability survey of United Kingdom adults, we extend this prior work in 2 regards. First, we ask whether people with more extreme attitudes, be they positive or negative, are more likely to believe that they understand the science. Second, as negativity to genetics is commonly framed around issues particular to specific technologies, we ask whether attitudinal trends are contingent on specification of technology. We find (1) that individuals with strongly positive or negative attitudes towards genetics more strongly believe that they well understand the science; but (2) only for those most positive to the science is this self-confidence warranted; and (3) these effects are not contingent on specification of any particular technologies. These results suggest a potentially general model to explain why people differ in their degree of acceptance or rejection of science, this being that the more someone believes they understand the science, the more confident they will be in their acceptance or rejection of it. While there are more technology nonspecific opponents who also oppose GM technology than expected by chance, most GM opponents fit a different demographic. For the most part, opposition to GM appears not to reflect a smokescreen concealing a broader underlying negativity.
Fatal Animal Related Incidents on Australian Farms - a 20-Year Review

ABSTRACT Objectives To assess demographic and causal factors of fatal farm incidents involving animals in Australia. Methods Descriptive study of the National Coronial Information System for persons fatally injured by an animal on an Australian farm over the 2001–20 period. Data were analysed in relation to age, sex, state where incident occurred, work-relatedness and causal agents. Results There has been little change in the mean number of animal-related injury deaths across Australia in the 2001–20 period (mean 6.5), however this is a 35% reduction on an earlier 1989–92 assessment (mean 10). The majority of incidents (81%) involved horses (n = 75) and cattle (n = 31). Males were involved in 86 (66%) cases, with 54 female cases. People aged 60 years and over accounted for 46% of the cases, with more than half occurring during work. Of the decedents, 85% fell from or were struck by an animal at the time of the incident, with 40% resulting in a head injury. Conclusion While annualized case numbers have decreased slightly, the leading agents remain consistent with previous studies. The lack of genuine progress in addressing fatalities related to horses and cattle, along with the representation of older persons in the cohort, require attention drawing on the Hierarchy of Controls.
The cortical NG2‐glia response to traumatic brain injury

Traumatic brain injury (TBI) is a significant worldwide cause of morbidity and mortality. A chronic neurologic disease bearing the moniker of “the silent epidemic,” TBI currently has no targeted therapies to ameliorate cellular loss or enhance functional recovery. Compared with those of astrocytes, microglia, and peripheral immune cells, the functions and mechanisms of NG2‐glia following TBI are far less understood, despite NG2‐glia comprising the largest population of regenerative cells in the mature cortex. Here, we synthesize the results from multiple rodent models of TBI, with a focus on cortical NG2‐glia proliferation and lineage potential, and propose future avenues for glia researchers to address this unique cell type in TBI. As the molecular mechanisms that regulate NG2‐glia regenerative potential are uncovered, we posit that future therapeutic strategies may exploit cortical NG2‐glia to augment local cellular recovery following TBI.
Positron lifetime spectra for the noble gases

Lifetime spectra for positrons annihilating in helium gas have been measured at room temperature for gas densities up to 60 amagat. The equilibrium annihilation rate for the free positron component is proportional to the gas density D, in amagats, given by lambda 1=(0.793+or-0.004 D mu s-1 which is equivalent to Zeff=3.94+or-0.02 and is in good agreement with recent calculations. The variation of the equilibrium decay rate with gas density for the ortho-positron component is also linear, given by lambda 2=7.24+(0.1006+or-0.0006) D mu s-, which is consistent with pick-off quenching. No other long-lived component has been observed. For neon at room temperature, a shoulder region of width 1700+or-200 ns amagat has been established. Some new measurements for argon, krypton and xenon are also reported. A comparison is made with other recent measurements.
IDENTIFICATION OF STATISTICAL PROPERTIES OF CUTTING TOOL VIBRATIONS IN A CONTINUOUS TURNING OPERATION-CORRELATION TO STRUCTURAL PROPERTIES

The cutting force dynamics in alloyed steel, stainless steel and cast iron have been investigated, although a direct measurement of the cutting forces could not be carried out. Usually, the response of the tool holder shank is measured by strain gauges and will be dependent on the stochastic character of the applied load and the structural dynamic properties of the tool holder. The characterisation of the dynamic response of the tool holder shank relies here on a stochastic approach while the structural dynamic properties were evaluated by a normal mode analysis. The results from both the analysis and the experiments correlate well.
Pursuing personalized medicine for depression by targeting the lateral or medial prefrontal cortex with Deep TMS

BACKGROUND Major depressive disorder (MDD) can benefit from novel interventions and personalization. Deep transcranial magnetic stimulation (Deep TMS) targeting the lateral prefrontal cortex (LPFC) using the H1 coil was FDA cleared for treatment of MDD. However, recent preliminary data indicate that targeting the medial prefrontal cortex (MPFC) using the H7 coil might induce outcomes that are as good or even better. Here, we explored whether Deep TMS targeting the MPFC is noninferior to targeting the LPFC and whether electrophysiological or clinical markers for patient selection can be identified. METHODS The present prospective, multicenter, randomized study enrolled 169 patients with MDD for whom antidepressants failed in the current episode. Patients were randomized to receive 24 Deep TMS sessions over 6 weeks, using either the H1 coil or the H7 coil. The primary efficacy endpoint was the change from baseline to week 6 in Hamilton Depression Rating Scale scores. RESULTS Clinical efficacy and safety profiles were similar and not significantly different between groups, with response rates of 60.9% for the H1 coil and 64.2% for the H7 coil. Moreover, brain activity measured by EEG during the first treatment session correlated with clinical outcomes in a coil-specific manner, and a cluster of baseline clinical symptoms was found to potentially distinguish between patients who can benefit from each Deep TMS target. CONCLUSION This study provides a treatment option for MDD, using the H7 coil, and initial guidance to differentiate between patients likely to respond to LPFC versus MPFC stimulation targets, which require further validation studies. TRIAL REGISTRATION ClinicalTrials.gov NCT03012724. FUNDING BrainsWay Ltd.
Modeling faults among mountainous highway fatal crash-involved drivers with different route familiarity levels

Abstract Objective With the constrained topography and road geometry, adverse weather conditions and restricted roadway facilities, mountainous highway crash rates and fatality rates are much higher. Considering the potential influence of driver’s route familiarity level on driving behavior and fault assignment, this research investigates high- and low- route familiarity level drivers (HRF and LRF drivers) fault assignment in mountainous highway fatal crashes in Yunnan Province of China by examining factors of driver, crash/environment and pre-crash behaviors. Methods Yunnan Province is famous for its tourism, and tourism can also bring in many drivers with low-route familiarity levels. Spatial distance away from residence-based method is used for identifying route familiarity levels of the drivers in this study. We employed two separate binary logistic regression models to investigate the effects of the explanatory variables on the likelihoods that the HRF or LRF drivers were at fault in the mountainous highway fatal crashes. Results The results show that driver under alcohol influence, sharp turn, dawn/dusk and left turning are 4 common factors that significantly influence both HRF and LRF drivers’ fault assignments. Factors including driver age, driver seatbelt use, weather condition, road type, section type, lighting condition and pre-crash behaviors have different or opposite influences on HRF and LRF drivers’ fault assignments. HRF drivers are much easier to be distracted under the conditions that are without the need of extra attention. LRF drivers have much more difficulties in figuring out, responding to and making timely driving behavior adjustment to ensure their driving safety on the high-risk sections like tunnels, continuous long downhills and sharp turns. Street parking/backing and left turning of the LRF drivers are very serious problems on the mountainous highways in China. Conclusions There is a large difference of significant factors contributing to the fault assignment of HRF and LRF drivers in mountainous highway fatal crashes. Some more effective and targeted countermeasures are put forward for HRF and LRF drivers and transportation managers to improve mountainous highway traffic safety.
CO2-forced Late Miocene cooling and ecosystem reorganizations in East Asia

Significance A widespread Late Miocene reorganization of terrestrial environments between 7.5 and 5 My B.P. occurred within a global context of ocean sea surface temperature cooling (up to 6 °C) and climate change. Yet the timing of events on land and the overall driving mechanism remains poorly understood. We present a new land surface temperature record from the Chinese Loess Plateau in East Asia, which reveals that cooling and aridification occurred synchronously with ocean cooling, highlighting a global forcing mechanism. Our results in combination with general circulation simulations suggest that positive feedbacks between decreasing atmospheric CO2, global cooling, and enhanced land aridification promoted a major reorganization of ecosystems in East Asia during the Late Miocene.
Clinicopathologic and Molecular Analysis of Normal Karyotype Therapy-Related and De Novo Acute Myeloid Leukemia: A Multi-Institutional Study by the Bone Marrow Pathology Group.

PURPOSE Therapy-related acute myeloid leukemias (t-AML) are a heterogenous group of aggressive neoplasms that arise following exposure to cytotoxic chemotherapy and/or ionizing radiation. Many therapy-related myeloid neoplasms (t-MN) are associated with distinct chromosomal aberrations and/or TP53 alterations, but little is known about the clinicopathologic and molecular features of normal karyotype t-AML (NK-t-AML) and whether this t-MN subtype is distinctly different from NK de novo AML (NK-dn-AML). METHODS This multi-institutional study by the Bone Marrow Pathology Group retrospectively evaluated clinicopathologic and molecular characteristics of 335 patients with NK-AML, comprising 105 t-AML and 230 dn-AML cases. RESULTS Patients with t-AML compared with dn-AML exhibit significantly shorter overall survival (OS; median months: 17.6 v 44.2; P < .0001) and relapse-free survival (RFS; median months: 9.1 v 19.2; P = .0018). Frequency of NPM1, FLT3, KRAS, and GATA2 mutations were significantly different in NK-t-AML compared with NK-dn-AML (NPM1 35% v 49%; P = .0493; FLT3 23% v 36%; P = 0494; KRAS 12% v 5%; P = .0465; GATA2 9% v 2% P = .0105), while TP53 mutations were rare. Patients with t-AML more often stratified into intermediate or adverse 2017 ELN genetic risk groups. Favorable ELN risk predicted favorable OS (hazard ratio [HR], 0.4056; 95% CI, 0 to 0.866; P = .020) and RFS (HR, 0.355; 95% CI, 0 to 0.746; P = .006). Among all patients with NK-AML, stem-cell transplant and favorable ELN risk both significantly affected RFS, while therapy-relatedness and age had a borderline significant impact on OS (HR, 1.355; 95% CI, 0.975 to 1.882; P = .070). CONCLUSION To our knowledge, this is the largest study to date to comprehensively evaluate NK-t-AML and provides a framework that may inform our understanding of NK-t-AML disease biology and could potentially help guide therapeutic management and improved disease classification in t-MNs that lack cytogenetic aberrations.
Prevalence of Oestrus ovis in small ruminants from the eastern Iberian Peninsula. A long‐term study

Oestrus ovis is an obligate parasite that causes myiasis in domestic ruminants, being commonly found in the Mediterranean area. From 2009 to 2019 a total of 3476 heads of culling sheep and goats from the Mediterranean coast of Spain were examined for the presence of O. ovis. The total prevalence was 56.3%, significantly higher in sheep than in goats (61.2% and 43%, respectively). Differences were found in the mean annual prevalence, with the highest value being registered in 2018 (61.7%) and the lowest in 2012 (50.3%). Autumn, for sheep, and winter, for goats, were the seasons with the highest number of infested specimens. Temperature, but not rainfall, was found to be associated with prevalence (p < 0.05). Most L1 were found in the anatomic region I (septum, meatus, and ventral conchae), while L2 and L3 were mainly located in regions II (nasopharynx, ethmoid labyrinth, and dorsal conchae), and III (sinuses). The overall intensity was 12.8 larvae per head, significantly higher in sheep (13.3) than in goats (3.5). Our results confirm the high prevalence of O. ovis in sheep and goats in this geographic area over the last decade, with the trend increasing in recent years in association with higher mean temperatures.
Performance validity tests in nonlitigant patients with functional motor disorder

Performance validity tests (PVTs) are used in neuropsychological assessments to detect patterns of performance suggesting that the broader evaluation may be an invalid reflection of an individual's abilities. Data on functional motor disorder (FMD) are currently poor and conflicting. We aimed to examine the rate of failure on three different PVTs of nonlitigant, non‐compensation‐seeking FMD patients, and we compared their performance to that of healthy controls and controls asked to simulate malingering (healthy simulators).
Serum FGF19 predicts outcomes of Kasai portoenterostomy in biliary atresia

Background and Aims: Outcomes after Kasai portoenterostomy (KPE) for biliary atresia remain highly variable for unclear reasons. As reliable early biomarkers predicting KPE outcomes are lacking, we studied the prognostic value of FGF19. Approach and Results: Serum and liver specimens, obtained from biliary atresia patients (N=87) at KPE or age-matched cholestatic controls (N=26) were included. Serum concentration of FGF19 and bile acids, liver mRNA expression of FGF19, and key regulators of bile acid synthesis were related to KPE outcomes and liver histopathology. Immunohistochemistry and in situ hybridization were used for the localization of liver FGF19 expression. Serum levels (223 vs. 61 pg/mL, p<0.001) and liver mRNA expression of FGF19 were significantly increased in biliary atresia. Patients with unsuccessful KPE (419 vs. 145 pg/mL, p=0.047), and those subsequently underwent liver transplantation (410 vs. 99 pg/mL, p=0.007) had significantly increased serum, but not liver, FGF19, which localized mainly in hepatocytes. In Cox hazard modeling serum FGF19 <109 pg/mL predicted native liver survival (HR: 4.31, p<0.001) also among patients operated <60 days of age (HR: 8.77, p=0.004) or after successful KPE (HR: 6.76, p=0.01). Serum FGF19 correlated positively with increased serum primary bile acids (R=0.41, p=0.004) and ductular reaction (R=0.39, p=0.004). Conclusions: Increased serum FGF19 at KPE predicted inferior long-term native liver survival in biliary atresia and was associated with unsuccessful KPE, elevated serum primary bile acids, and ductular reaction.
Factors Associated With Peripheral Nerve Injury After Pelvic Laparoscopy: The Importance of Surgical Positioning

ABSTRACT Background Nerve damage after abdominal and pelvic surgery is rare but potentially serious. The incidence of peripheral nerve injury is difficult to assess, and rates of between 0.02% and 21% have been cited in the literature. Signs and symptoms of this type of injury may appear immediately after surgery or a few days later. Purpose This study was developed to assess the rate of peripheral nerve injury after pelvic laparoscopy and to identify associated risk factors. Methods A pilot prospective cohort study was conducted between March 2018 and April 2019 on 101 patients with a 1-month follow-up using two semistructured clinical interviews. We carried out a descriptive analysis followed by univariable and multivariable logistic regression analyses. Results Thirteen patients were found to have peripheral nerve injuries, representing a rate of 12.9%. Overall, 14 injuries (five severe and nine mild) were detected. One patient had two mild injuries. In this study, the risk of injury was found to increase 1.77-fold (OR = 1.77, 95% CI [1.13, 2.76], p = .007) for each hour the patient was in the Trendelenburg position. Conclusions/Implications for Practice The longer the patient is in the Trendelenburg position, the greater the risk of peripheral nerve damage. Patients aged 60 years or less also face a higher risk of nerve injury.
Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia

Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times (approximately 3 PM/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes.
Human VH-based chimeric antigen receptor T cells targeting glypican 3 eliminate tumors in preclinical models of HCC

Background and Aims: Efficacy of chimeric antigen receptor (CAR) T cells for treating solid tumors, including HCC, remains a challenge. Nanobodies are emerging building blocks of CAR T cells due to their small size and high expression. Membrane proximal sites have been shown as attractive epitopes of CAR T cells. However, current CAR formats are not tailored toward nanobodies or targeting membrane distal epitopes. Approach and Results: Using hYP7 Fv (membrane proximal) and HN3 VH nanobody (membrane distal) as GPC3 targeting elements, we sought to determine how hinges and transmembrane portions of varying structures and sizes affect CAR T-cell function. We generated multiple permutations of CAR T cells containing CD8, CD28, IgG4, and Fc domains. We show that engineered HN3 CAR T cells can be improved by 2 independent, synergistic changes in the hinge and transmembrane domains. The T cells expressing the HN3 CAR which contains the hinge region of IgG4 and the CD28 transmembrane domain (HN3-IgG4H-CD28TM) exhibited high cytotoxic activity and caused complete HCC tumor eradication in immunodeficient mice. HN3-IgG4H-CD28TM CAR T cells were enriched for cytotoxic-memory CD8+ T cells and NFAT signals, and reduced β catenin levels in HCC cells. Conclusion: Our findings indicate that altering the hinge and transmembrane domains of a nanobody-based CAR targeting a distal GPC3 epitope, in contrast to a membrane proximal epitope, lead to robust T-cell signaling and induce swift and durable eradication of HCC tumors.
Granger Causal Chain Discovery for Sepsis-Associated Derangements via Continuous-Time Hawkes Processes

Modern health care systems are conducting continuous, automated surveillance of the electronic medical record (EMR) to identify adverse events with increasing frequency; however, many events such as sepsis do not have elucidated prodromes (i.e., event chains) that can be used to identify and intercept the adverse event early in its course. Clinically relevant and interpretable results require a framework that can (i) infer temporal interactions across multiple patient features found in EMR data (e.g., Labs, vital signs, etc.) and (ii) identify patterns that precede and are specific to an impending adverse event (e.g., sepsis). In this work, we propose a linear multivariate Hawkes process model, coupled with ReLU link function, to recover a Granger Causal (GC) graph with both exciting and inhibiting effects. We develop a scalable two-phase gradient-based method to obtain a maximum surrogate-likelihood estimator, which is shown to be effective via extensive numerical simulation. Our method is subsequently extended to a data set of patients admitted to Grady hospital system in Atlanta, GA, USA, where the estimated GC graph identifies several highly interpretable GC chains that precede sepsis. The code is available at https://github.com/SongWei-GT/two-phase-MHP.
Cyanopolyyne Chemistry in the L1544 Prestellar Core: New Insights from GBT Observations

We report a comprehensive study of the cyanopolyyne chemistry in the prototypical prestellar core L1544. Using the 100 m Robert C. Byrd Green Bank Telescope, we observe three emission lines of HC3N, nine lines of HC5N, five lines of HC7N, and nine lines of HC9N. HC9N is detected for the first time toward the source. The high spectral resolution (∼0.05 km s−1) reveals double-peak spectral line profiles with the redshifted peak a factor 3–5 brighter. Resolved maps of the core in other molecular tracers indicate that the southern region is redshifted. Therefore, the bulk of the cyanopolyyne emission is likely associated with the southern region of the core, where free carbon atoms are available to form long chains, thanks to the more efficient illumination of the interstellar field radiation. We perform a simultaneous modeling of the HC5N, HC7N, and HC9N lines to investigate the origin of the emission. To enable this analysis, we performed new calculation of the collisional coefficients. The simultaneous fitting indicates a gas kinetic temperature of 5–12 K, a source size of 80″, and a gas density larger than 100 cm−3. The HC5N:HC7N:HC9N abundance ratios measured in L1544 are about 1:6:4. We compare our observations with those toward the well-studied starless core TMC-1 and with the available measurements in different star-forming regions. The comparison suggests that a complex carbon chain chemistry is active in other sources and is related to the presence of free gaseous carbon. Finally, we discuss the possible formation and destruction routes in light of the new observations.