Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety Comparison of Atomextine and Lisdexamfetamine: Using Pharmacovigilance Database and Tools

Background Our study is the first to utilize the OpenVigil 2.1, a universal novel web-based pharmacovigilance analysis tool to analyze real-life safety of ADHD medications with special emphasis on newer medications and psychiatric adverse events. Thorough knowledge of adverse events for each medication reveals safety signals and support treatment guidelines and clinical management of the events. Methods we analyzed adverse event cases documented in the OpenVigil 2.1 from mid-2003 until February 2020. The medical dictionary for regulatory activities (MedDRA browser English version 20.0) was used to group lower level terms with a common preferred term to be searched for in the database. The proportional reporting ratio (PRR) and the reporting odd ratio (ROR) were used to quantitate the strength of the association between reported adverse events for atomoxetine, lisdexamfetamine, amphetamine, methylphenidate (instant release, intermediate acting, long acting). Results During the period we evaluated a total of 38,412 cases reported for methylphenidate, atomoxetine, lisdexamfetamine, amphetamine. We found a significantly lower risk for depressed mood (ROR 0.026, 95%CI 0.016-0.042) and tics (ROR 0.48, 95%CI 0.30-0.76) reported for atomoxetine compared with methylphenidate. Lisdexamphetamine did not seem to decrease the risk of psychiatric events. On the contrary, lisdexamfetamine carried a six fold risk for suicidal adverse events compared with other drugs in the data and a twofold risk of suicidal adverse events and tics compared with methylphenidate. Conclusions we conclude that Atomoxetine is a good choice for patients with comorbid tics or depression or for patients who develop depressed mood on stimulants. There is a great overlap between ADHD symptoms and stimulant/non stimulant adverse events, therefore prior to medication switch, therapeutic response should be evaluated carefully. Data in the literature on lisdexamfetamine remains scarce. Owing to signals on tic disorders and suicidal adverse events, we highly recommend studying these issues further with RCT and Cohort studies.
Development of a Heating System for Point-of-Care Microfluidic Applications

In this work, a heating system envisioned to be used for microfluidic devices was designed and fabricated. The area of microfluidics is one of intense growth and relevant to various fields of study, sometimes requiring heating capabilities. For this endeavour, simulation work was conducted to plan the microfabrication of microheaters to investigate both appropriate designs and materials such as ITO and TiW. For the final heaters, of Generation II, a maximum temperature uniformity of 1.33% and 2.33% for TiW and ITO was obtained, in addition to a maximum temperature instability of 0.81 oC. For microchannel temperature assessment, fluorescence thermometry with Rhodamine B was used and a calibration reaching 100oC with a sensitivity of 1.07%/oC was obtained, which allowed the modulation of temperature for a DNA chip and a cell chip. Finally, this understanding was applied to a real device, a cell chip, and the developed methodology was validated as appropriate for usage as a microheater for cell culture growth.
The Effect of Cranial Cruciate Ligament Rupture on Range of Motion in Dogs

Range of motion (ROM) is a measure often reported as an indicator of joint functionality. Both the angle of extension and that of flexion were measured in 234 stifle joints of dogs with cranial cruciate ligament (CCL) rupture. The aims of this study were to investigate the correlation between CCL rupture and alterations in the range of stifle joint motion and to determine whether there was a prevalence modification of one of the two angles. All the extension and flexion angles were obtained from clinical records and were analysed in various combinations. A significant relationship was found between normal angles and abnormal angles; concerning the reduction in the ROM, a significant prevalence in the alteration extension angle was found. Of the 234 stifles, 33 (13.7%) were normal in both angles. These results could offer important insights regarding the influence of CCL rupture on compromising the ROM. This awareness could be a baseline for understanding the ability of surgical treatment to restore one angle rather than another angle, to address the choice of treatment and to help physiotherapists in their rehabilitation program.
GENERAL RETAIL STOCK-OUTS: TO WHICH EXTENT IS THE CONSUMER LOYALTY BEHAVIOR AFFECTED?

Les ruptures de stocks sont un probleme que les magasins de distribution doivent faire face, en vue de recruter et fideliser leurs clients. En effet, un taux eleve de ruptures dans le lineaire dans un magasin, entrainera une insatisfaction et un bouche a oreille negatif de la part des clients. La fidelite de ces dernies au magasin se trouve affectee. Cette recherche vise a etudier l’impact de la frequence des ruptures de stock dans la grande distribution generaliste, sur la fidelite de ses clients au Maroc. Notre etude a cible une population de 657 clients de differentes chaines de grande distribution. Les resultats de notre etude ont montre que la frequence des ruptures de stock affecte negativement la fidelite comportementale des clients. The out-of-stocks (OOS) have become one of the major problems retailers have to resolve in order to retain their existing customers and attract new ones. This is particularly because the stock-outs rates could lead to non-satisfaction and negative word of mouth. This would affect the client loyalty toward the store. Through this paper, we study the implications of frequent OOS situations in the customers’ loyalty behaviors in the large general retail sector in Morocco. Our study considers a population of 657 customers of the different large general retail chains in Morocco. Our research findings indicate that repeated OOS have a negative impact on the client’s behavioral loyalty.
Gas-Kinetic Scheme for Hypersonic Plasma Aerodynamics

*† ‡ Kinetic Flux-Vector Splitting scheme is constructed to simulate weakly ionized hypersonic flows with 11-species air model. In the gas kinetic model, each species has its own individual gas distribution function. However, these gas distribution functions are not independent. Due to the momentum and energy exchange in particle collisions between all species, the equilibrium states of all species are assumed to have the common velocity and temperatures. For taking into account thermal non-equilibrium, a two-temperature model is used and the Maxwellian distribution function is generalized, in which the translational and rotational energy modes are assumed to be in equilibrium at the translational temperature, and the vibrational, electronic, and electron translational energy modes are assumed to be in equilibrium at the vibrational temperature.
New Criterion of Airway Assessment-B Pilot, Straight Single Sectional Study of Short Neck

Results: Airway assessment using anthropometric measurements, including neck length, were documented prior to anesthesia. Operators (anesthesiologists) were blinded. Intubation Difficult Scale was used. All data were documented and analysed afterwards. Patients were of three groups according to Intubation Difficulty Scale (IDS): Group A: IDS 0, Group B: IDS>0≤ 5 and Group C: IDS>5. Five patients (5.2%) with intubation difficulty score > 5 have a mean neck length 7.6 cm. “Short Neck” was found to have a significant p value 0.022 within the three groups.
Repurchase Intention among Mobile Shoppers with Mediating Effect of Satisfaction on Mobile Shopping

Good continuation of mobile shoppers’ intention could ensure sustainability in mobile shopping, thus the study of consumer behavior including service quality, perceived value, trust and satisfaction is essential in order to understand their needs. The question is whether the mobile shopping in Malaysia has provided sufficient mobile websites or apps facilities to gain the repurchase intention of mobile shoppers. However, there are several issues arise such as bad reviews or comments, lack of communication and fake online sellers that may affect mobile shoppers’ behaviour. This research aims to examine the relationship between service quality (SQ), perceived value (PV) and trust (TR) mediated by mobile shoppers’ satisfaction (CS) with repurchase intention (RI). 427 usable questionnaires were collected from the mobile shoppers around Kuala Lumpur and Selangor. The data was analyzed using SPSS and Structural Equation Modelling in SmartPLS. The results suggested that there is a significant relationship between SQ, PV and TR on CS. Besides, CS mediates the relationship between SQ, PV and TR with RI. The research has extended the body of knowledge in mobile shopping studies. The findings contribute valuable theoretical and managerial implications that can enhance mobile shopping services.
Determination of Tetrahydropalmatine in Rhizoma Corydalis

Objective To establish an assay method of tetrahydropalmatine in Rhizoma Corydalis.Methods By RP-HPLC, using a C 18 column with acetonitrile-2% acetic acid glacial(adjusted pH to 5.0 with triethylamine)(25∶75)as mobilephase and detected at 282 nm.Results The calibration curve of tetrahydropalmatine was linear from 1.004 μg/mL to 50.20 μg/mL with r=0.999 9.The average recovery was 98.63 % with RSD 1.95%. Conclusion This method was proved to be accurate and quick, and can be selected to control the quality of the medicinal materials.
Recidivists, Rough Sleepers, and the Unemployed as Financial Assets: Social Impact Bonds and the Creation of New Markets in Social Services

One of the enduring ironies of the financial crisis of 2008 is that these events did little to challenge neoliberal rationalities, with markets continuing to be viewed as a response to all manner of social problems (Mirowski 2013). A perfect expression of this valorization of marketbased solutions comes from the social services sector and the emergence of a new, investmentbased funding model, the social impact bond (SIB). Pioneered in the UK in 2010, a SIB is an investment contract in which private investors provide upfront funding for a preventative program. If the program is successful in meeting predefined performance targets, the government repays the investment and provides a return based on the cost savings realized from reduced future demand on public services. The result is a winwinwin scenario. Nonprofits receive multiyear, more flexible funding. Governments are able to deliver preventative services while only paying for success. And investors receive a financial return while also doing good. These benefits have helped fuel the global expansion of the model, which has been exported to the US, Australia, Canada, and parts of Europe, and applied to a range of issues, including reoffending, homelessness, child welfare, education, and employment (Carter et al. 2018). As the SIB market has grown, so too has the number of critics. Commentators in policy and academic circles have cited concerns ranging from the failure to deliver on promised cost savings, to perverse incentives, to the erosion of agency autonomy and mission (Cooper et al. 2016; Edmiston and Nicholls 2018; Fraser et al. 2018a; McHugh et al. 2013; Neyland 2018; Warner 2013). A key theme running through many critical accounts is that SIBs are indicative of the marketization (Joy and Shields 2013; Sinclair et al. 11 Recidivists, Rough Sleepers, and the Unemployed as Financial Assets: Social Impact Bonds and the Creation of New Markets in Social Services
Microsoft Word-ggaa534.docx

A number of seismological studies have indicated that the ratio R of S-wave and P-wave velocity perturbations increases to 3–4 in the lower mantle with the highest values in the large low-velocity provinces (LLVPs) beneath Africa and the central Pacific. Traveltime constraints on R are based primarily on ray-theoretical modelling of delay times of P waves (ΔTP) and S waves (ΔTS), even for measurements derived from long-period waveforms and core-diffracted waves for which ray theory is deemed inaccurate. Along with a published set of traveltime delays, we compare predicted values of ΔTP, ΔTS, and the ΔTS / ΔTP ratio for ray theory (RT) and finite-frequency theory (FF) to determine the resolvability of R in the lower mantle. We determine the FF predictions of ΔTP and ΔTS using crosscorrelation methods applied to spectral-element method waveforms, analogous to the analysis of recorded waveforms, and by integration using finite-frequency sensitivity kernels. Our calculations indicate that RT and FF predict a similar variation of the ΔTS / ΔTP ratio when R increases linearly with depth in the mantle. However, variations of R in relatively thin layers (< 400 km) are poorly resolved using longperiod data (T > 20 s). This is because FF predicts that ΔTP and ΔTS vary smoothly with epicentral distance even when vertical P-wave and S-wave gradients change abruptly. Our waveform simulations also show that the estimate of R for the Pacific LLVP is strongly affected by velocity structure shallower in the mantle. If R increases with depth in the mantle, which appears to be a robust inference, the acceleration of P waves in the lithosphere beneath eastern North America and the high-velocity Farallon anomaly negates the P-wave deceleration in the LLVP. This results in a ΔTP of about 0, whereas ΔTS is positive. Consequently, the recorded high ΔTS/ΔTP for events in the southwest Pacific and stations in North America may be misinterpreted as an anomalously high R for the Pacific LLVP.
On relation between totality semantic and syntactic validity

In this paper, we present a denotational semantic for non-wellfounded proofs of μLL∞, linear logic extended with least and greatest fixed points, by adapting the categorical semantics of μLL∞ [EJ21]. Two instances of this categorical setting are REL (category of sets and relations), and NUTS (category of sets equipped with a notion of totality and relations preserving it) which is studied in [EJ21]. In particular, we relate validity condition for non-wellfounded proofs and totality of NUTS. More precisely, we show each μLL∞ valid proof will have interpreted as a total element in NUTS.
Active Measures of Spatial Cognition

Spatial cognition is how we navigate and perceive the space around us. Distance estimation is one of the elements of spatial cognition. A previous study was done to test if the presence of boundaries has an effect of distance estimation. In the present study, this same phenomenon was tested using an action-based task to examine how this affected distance estimation. Participants were asked to stand at the end of three runners and throw bean bags at a target on the other end of the runner. One runner had an open throwing path, another runner had a doorway in the throwing path, and the last runner had a board in the throwing path. Distances of the runners and the targets were all the same. The reported analyses contrasted the thrown distances across each of these stimulus conditions. The results found that there was no significant difference in distance thrown between each condition. The results also did not find any significant difference in the order in which they completed the conditions or between each individual toss. These inconclusive findings are in contrast with previous research and suggests a possible difference between explicit quantified distance estimation and how we perform distance relevant actions.
Comparison of dynamic lung functions among female workers of ballari jeans industry with non-working group of females

Among various health assessment tools for industrial workers, Pulmonary Function Test (PFT) is one of the most popular tools. PFT results are closely related to people s lifestyle. People who perform regular exercises are found to have good results in PFT. Physical activity demands strong cardiopulmonary system that is again responsible for the body s physiological condition. The objective of this study is to compare pulmonary functions among the female workers of jeans industry in Ballari with normal healthy subjects.50 females working in various jeans manufacturing units of Ballari and 50 housewives, each between ages 18-35 years were selected for the study. This study is a comparative study and was conducted over a period of 3 months i.e., December 2020 to February 2021, When Covid-19 crisis (first wave) had subsided completely. The study requires onetime assessment of lung functions of the 100 female participants (50 jeans factory workers and 50 housewives) using RMS Helios-401 PC based Spirometer which is owned by the principal investigator. In the research, the same effect has been observed among females working in a factory and the females not working in a factory. Here these females are potentially exposed to dirt and toxic chemicals, due to which the working of their respiratory function has reduced.
Temporal Head Pose Estimation From Point Cloud in Naturalistic Driving Conditions

Head pose estimation is an important problem as it facilitates tasks such as gaze estimation and attention modeling. In the automotive context, head pose provides crucial information about the driver’s mental state, including drowsiness, distraction and attention. It can also be used for interaction with in-vehicle infotainment systems. While computer vision algorithms using RGB cameras are reliable in controlled environments, head pose estimation is a challenging problem in the car due to sudden illumination changes, occlusions and large head rotations that are common in a vehicle. These issues can be partially alleviated by using depth cameras. Head rotation trajectories are continuous with important temporal dependencies. Our study leverages this observation, proposing a novel temporal deep learning model for head pose estimation from point cloud. The approach extracts discriminative feature representation directly from point cloud data, leveraging the 3D spatial structure of the face. The frame-based representations are then combined with bidirectional long short term memory (BLSTM) layers. We train this model on the newly collected multimodal driver monitoring (MDM) dataset, achieving better results compared to non-temporal algorithms using point cloud data, and state-of-the-art models using RGB images. We further show quantitatively and qualitatively that incorporating temporal information provides large improvements not only in accuracy, but also in the smoothness of the predictions.
Study of the Enhanced Role of Latanoprost Combined with Narrow Band Ultraviolet B Rays in Vitiligo Repigmentation

Heba Gamal Elsheikh,Al_Mokadem S, and Abdulla Esawy Dermatology resident at Al-Ahrar hospital-Zagazig Professor of Dermatology, Venereology & Andrology,Faculty of MedicineZagazigUniversity. Assistant Professor of Dermatology, Venereology & Andrology,Faculty of Medicine Zagazig University. Correspondingauthor:Heba Gamal Ibrahim Email:hobygamal555@gmail.com Abstract Background:Vitiligo is an acquired, autoimmune disease characterized by depigmented macules and patches on the skin, which occur secondary to melanocyte destruction. Focal and segmental vitiligo patterns involve ≤10% body surface area (BSA) and are considered stable patterns. Generalized vitiligo typically involves ≥10% BSA, appears bilaterally in a symmetric distribution, and generally follows a relapsing and remitting disease course. The pathogenesis is complex and involves the interplay of multiple factors; however, the exact pathogenesis is not well known. In particular, the autoimmune mechanism is clearly established. Vitiligo may appear at any age and affect both sexes.Treatment can be challenging, though available modalities of therapy include pharmacologic, surgical, and phototherapy. Appropriate characterization of vitiligo type, consideration of disease extent and duration, and efficacy of prior therapies can guide management and maximize treatment efficacy.Latanoprost was documented to stimulate prostaglandin E2(PGE2) formation, and repigmentation is likely to be induced in part by endogenous PGE2 which acts as a melanogenic stimulator.Narrow band UVB rays are one of the safest and most effective therapeutic modalities of vitiligo. It emits wavelengths between 310 and 315 nm. This specific wavelength is very effective in vitiligo because it can stimulate the dormant skin melanocytes and also modulate the cutaneous immune system.
A Complete Theory of Planar Cognate Linkages

Cognate linkages provide the useful property in mechanism design of having the same motion. This paper describes a method for determining all coupler curve cognates for planar linkages with rotational joints. Although a prior compilation of six-bar cognates due to Dijksman purported to be a complete list, that analysis made certain assumptions that were never demonstrated rigorously. We approach the question without making such assumptions to provide a complete theory. Our approach uses arguments concerning the singular foci of the coupler curve to constrain a cognate search and then uses homotopy continuation to complete it. Our analysis confirms that Dijksman’s list is in fact comprehensive and it also provides a method of treating the question of cognates for higher order linkages.
Inclusion of vegetable oils in diets of broiler chicken raised in hot weather and effects on antioxidant capacity, lipid components in the blood and immune responses

The aim of this study was to assess the effects of vegetable oils on the antioxidant capacity, blood lipid components and immune responses in chickens raised in hot climate. In a completely randomized design, 300 chicks were assigned to four treatments and five replicates with 15 chicks per each. The highest concentration of malondialdehyde was found in broilers fed palm oil (p < 0.05). Chickens fed corn oil had the lowest and those fed flaxseed oil had the highest antioxidant enzymes activities (p < 0.05). The highest hepatic Alanine-transferase and Aspartate-transferase was found in chickens fed corn oil and the lowest levels in those received flaxseed and olive oils (p < 0.05). The highest hypersensitivity was in chickens fed palm oil and the lowest was for olive oil. The highest antibody titer against sheep red blood cells was found in chickens fed flaxseed oil and the lowest titer was for those received palm oil (p < 0.05). The highest triglyceride, cholesterol and very low density lipoprotein and the lowest high density lipoprotein was found in chickens fed palm oil and vice versa for flaxseed and olive oils. Olive and flaxseed oils had beneficial effects on antioxidant activity and lipid attributes and palm oil had detrimental effects on these parameters that related to the poultry health.
The Smart Forest Conundrum: Contextualizing Pitfalls of Sensors and AI in Conservation Science for Tropical Forests

The term ‘smart forest’ is not yet common, but the proliferation of sensors, algorithms, and technocentric thinking in conservation, as in most other aspects of our lives, suggests we are at the brink of this evolution. While there has been some critical discussion about the value of using smart technology in conservation, a holistic discussion about the broader technological, social, and economic interactions involved with using big data, sensors, artificial intelligence, and global corporations is largely missing. Here, we explore the pitfalls that are useful to consider as forests are gradually converted to technological sites of data production for optimized biodiversity conservation and are consequently incorporated in the digital economy. We consider who are the enablers of the technologically enhanced forests and how the gradual operationalization of smart forests will impact the traditional stakeholders of conservation. We also look at the implications of carpeting forests with sensors and the type of questions that will be encouraged. To contextualize our arguments, we provide examples from our work in Kibale National Park, Uganda which hosts the one of the longest continuously running research field station in Africa.