Miracle-dz/UniFAR-FTUs huggingface dataset:
Imaging Breast Cancer Chemotherapy Response with Light: Commentary on Soliman et al., p. 2605

Diffuse optical spectroscopy (DOS), which is used to image tumor metabolic response to neoadjuvant chemotherapy (NAC), shows large changes in tumor functional parameters with significant reductions in oxy- and deoxyhemoglobin for responders versus nonresponders. Although investigational, DOS may provide a cost-effective, risk-free method for optimizing NAC drug and dosing strategies for individual patients. In the current issue of Clincal Cancer Rese arch, Soliman and colleagues describe the use of an investigational functional imaging technology, diffuse optical spectroscopy (DOS), for determining the response of breast cancer patients to presurgical neoadjuvant chemotherapy ref. 1). and breast tissue and as methods would potentially give oncologists new tools for individualized cancer therapy that could be used to duration 2 , percent water, and scatter power. Corresponding drops in the four nonresponders were 17.7%, 18.0%, 15.4%, and 12.6%. Differences between responders and nonresponders were statistically significant for all parameters ( P < 0.05) except for percent water, which approached significance ( P = 0.0598). These results are comparable to a recent 11-patient study in which separation between responders and nonresponders was achieved within 1 week of therapy (6). A key difference was that all patients in the 11-patient study (6) received identical Adriamycin/Cytoxan (AC) treatments, whereas Soliman and colleagues followed 10 patients who had much greater diversity in both disease extent and treatment strategy. These results provide further support for the idea that quantitative functional imaging endpoints can be used to longitudinally monitor and predict clinical treatment response, regardless of the chemotherapeutic strategy, agent, or dose. Patterns of DOS response include an overall decrease in tumor hemoglobin due to drug-induced alterations in tumor cell metabolism and blood vessel density. More specifically, the oxyhemoglobin decrease reflects a diminished vascular supply, whereas the deoxyhemoglobin drop is representative of a reduction in tumor tissue oxygen consumption that occurs with cell death. Water and scatter power are also sensitive to cell death, and their reduction reflects a progressive loss of cellularity and edema. These changes were clearly observed at week 4, and continued to evolve until the completion of therapy despite the use of a variety of treatment regimens, including the targeted agent trastuzumab (herceptin), cytotoxic compounds, and chemoradiotherapy.
A Case of Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules

: A 39-year-old woman received a seasonal influenza vaccine in November 2015 and subsequently experienced malaise, low-grade fever, and chest discomfort. A chest X-ray performed 2 weeks after vaccination showed multiple nodular shadows in both lungs and ground-glass shadows in both lower lung fields. Her bronchoalveolar lavage fluid contained an unusually high number of lymphocytes, and a drug-induced lymphocyte stimulation test for seasonal influenza vaccine was positive. Transbronchial lung biopsy revealed the presence of granulomatous inflammation. Thereafter her abnormal chest shadow spontaneously improved. Based on these findings, the patient was diagnosed with drug-induced pneumonitis due to an influenza vaccine.
Relationship Between Emotional Intelligence and Examination Malpractice Tendency Among University Undergraduates in Anambra State

The study investigated the relationship between emotional intelligence and examination malpractice tendency among university undergraduates in Anambra State. A correlational design was used in this study. The study was guided by three research questions and one null hypothesis. The population of this study comprises 300 level undergraduates from Nnamdi Azikiwe University, Awka and 300 level undergraduates from Chukwuemeka Odumegwu Ojukwu University Igbariam. The sample was 851 respondents sample from two universities, Nnamdi Azikiwe University and Chukwuemeka Odumegwu Ojukwu University Igbariam. Data for the study was collected using two instruments titled “Emotional Intelligence Questionnaire” developed by singh (2004) and “Questionnaire on Examination Malpractice tendency” developed by Arjen (2009). Aggregate scores, Pearson product movement correlation and regression analysis were used for data analysis. The findings indicated that majority of the university undergraduate students have low emotional intelligence. The findings showed that only few of the university undergraduate students have high examination malpractice tendency. The findings also revealed that there is a low negative significant relationship between the emotional intelligence of university undergraduate students in Anambra State and their examination malpractice tendency. It was recommended among others that curriculum experts should develop an effective instructional curriculum that incorporates emotional intelligence skills with the objective of enhancing personal and career success of students.
Fratricide Is Essential for Efﬁcient Gene Transfer between Pneumococci in Bioﬁlms

Streptococcus pneumoniae and a number of commensal streptococcal species are competent for natural genetic transformation. The natural habitat of these bacteria is multispecies bioﬁlms in the human oral cavity and nasopharynx. Studies investigating lateral transfer of virulence and antibiotic resistance determinants among streptococci have shown that interspecies as well as intraspecies gene exchange takes place in these environments. We have previously shown that the action of a competence-spe-ciﬁc murein hydrolase termed CbpD strongly increases the rate of gene transfer between pneumococci grown in liquid cultures. CbpD is the key component of a bacteriolytic mechanism termed the fratricide mechanism. It is secreted by competent pneumococci and mediates the release of donor DNA from sensitive streptococci present in the same environment. However, in nature, gene exchange between streptococci takes place in bioﬁlms and not in liquid cultures. In the present study, we therefore investigated whether CbpD affects the rate of gene transfer in laboratory-grown bioﬁlms. Our results show that the fratricide mechanism has a strong positive impact on intrabioﬁlm gene exchange, indicating that it is important for active acquisition of homologous donor DNA under natural conditions. Furthermore, we found that competent bioﬁlm cells of S. pneumoniae acquire a Nov r marker much more efﬁciently from neighboring cells than from the growth medium. Efﬁcient lysis of target cells requires that CbpD act in conjunction with the murein hydrolase LytC. In contrast, the major autolysin LytA does not seem to be important for fratricide-mediated gene exchange in a bioﬁlm environment. after
The Severity and Prognostic Markers of 148 Cases of Carbon Monoxide Poisoning by Burning Charcoal

Objective To identify and analyse the characteristics of carbon monoxide (CO) poisoning due to burning charcoal in our locality. Methods This was a 3-year retrospective study. All patients presenting with CO poisoning by burning charcoal from August 1999 to December 2002 were recruited. The demographic data, initial vital signs, blood results, treatment regimens and outcomes were collected. Association between clinical outcomes and parameters were calculated. Results The study identified 148 patients (mean age 34.7 years) suffering from CO poisoning by burning charcoal. One hundred and forty-six cases (98.6%) were suicidal. Twenty-five patients (16.9%) were unconscious (GCS ≤ 8) on arrival. The mean initial carboxyhaemoglobin (COHb) level was 21.0%. The mortality rate was 5.4%. Fifteen cases (10.1%) required intensive care. Twelve cases (8.1%) had neurological complications and five (3.4%) suffered from delayed neurological sequelae. Initial blood results showing hyperkalemia and acidosis were associated with likelihood of unconsciousness on arrival (p = 0.007, p = 0.019 respectively). Hyperkalemia and unconsciousness on arrival were associated with longer hospital stay (p < 0.001, p < 0.001 respectively) as well as likelihood of systemic complication (p < 0.001, p < 0.001 respectively). There was no relationship between co-ingestion, age, initial COHb level, initial systolic and diastolic blood pressure with consciousness level on arrival (p = 0.188, p = 0.846, p = 0.264, p = 0.224, p = 0.755 respectively). Age, initial COHb level, acidosis, initial systolic and diastolic blood pressure did not correlate with the duration of hospital stay (p = 0.679, p = 0.176, p = 0.501, p = 0.313, p = 0.868 respectively). Conclusion Suicide almost accounted for all the CO poisonings by burning charcoal in our study group. It caused significant mortality and morbidity. Hyperkalemia, unconscious state and acidosis had prognostic values.
LibGuides: Epidemiology & Community Health: Ebooks, Ejournals & Databases

As the contributions of exercise to health and well being are becoming increasingly recognised, 1-3 interest in health promotion has stimulated demand for practical methods of assessment of physical activity patterns. Unfortunately, no methods are generally accepted, so it has become the custom for investigators to devise their own-often with scant reference to validity, and still less to comparability with other studies. Walking, for example, can range from gentle strolling to striding at a brisk pace.4 Yet frequently all walking will be graded as light activity. The manner in which walking is treated can, therefore, substantially affect individual classification for total activity and for aerobic exercise, since walking is the only sustained aerobic activity that is at all common in industrialised societies. The same applies to other important sources of exercise. Gardening, the commonest hobby involving physical "work" in this country, can vary in energy expenditure from pruning roses to heavy manual labour in a vegetable allotment, yet it is commonly graded as "moderate" activity.
AMOC Trends From 1850 to 2100 At Interannual To Multi-Decadal Time Scales Corroborated By Changes In Salinity Budget

The Atlantic Meridional Overturning Circulation (AMOC) is a key player in the global coupled ocean- 7 atmosphere climate system. To characterise the potential of an AMOC slowdown, a past and future trend probabil- 8 ity analysis is applied using 16 models from the Coupled Model Intercomparison Project Phase 5. We determine 9 the probability of AMOC annual to multidecadal trends under the historical period and two future climate scenar- 10 ios (‘business-as-usual’ scenario – RCP8.5 and ‘stabilisation’ scenario – RCP4.5). We show that the probability of 11 a AMOC decline in model data shifts outside its range of intrinsic variability (determined from the pre-industrial 12 control runs) for sustained 5-year trend or longer. This suggests that interannual AMOC events are not signiﬁ- 13 cantly affected by future climate scenario, and so potentially neither by anthropogenic forcing. Furthermore, under 14 the ‘business-as-usual’ scenario the probability of a 20-year decline remains high (87%) until 2100, however in a 15 ‘stabilisation’ scenario the trend probability recovers its pre-industrial values by 2100. A 20-year unique event is 16 identiﬁed from 1995 to 2015, marked by simultaneous unique features in the AMOC and salinity transport that are 17 not replicated over any other 20-year period within the 250 years studied. These features include the maximum 18 probability and magnitude of an ‘intense’ AMOC decline, and a sustained 20-year decline in subpolar salinity 19 transport caused by internal oceanic processes (as opposed to external atmospheric forcing). This work therefore 20 highlights the potential use of direct salinity transport observations, and ensemble mean numerical models to rep- 21 resent and understand changes in past, present, and future AMOC. 22 longer than 5 years. This suggests any interannual intense events, such as the 2009- 494 2010 30% decline in transport recorded by RAPID (Bryden et 2014), are more akin to intrinsic variability rather 495 than forced long-term decline. The results also imply that there was a probability (up to 85% at the turn of 496 the century, in RCP8.5) of seeing a weak decadal decline, such as that seen in RAPID (Smeed et al, 2014), due 497 to forcing. A decadal trend could still be dominated by intrinsic variability as suggested by Roberts et al (2014), 498 which is characterised as a hiatus in S´evellec et al (2016). Upon increasing the time-duration of the forced trends, 499 stronger intensities and probabilities of a decline seen (86% time-average probability of an intense 40-year 500 decline under RCP8.5). Using time-varying trends, the ‘business-as-usual’ scenario shows a sustained high 501 probability of a decline in the AMOC, the ‘stabilisation’ scenario returns to pre-industrial probabilities of 502 an equal chance in increasing
COMPARATIVE STUDY OF UNILATERAL SPINAL BLOCK WITH 0.5% HYPERBARIC BUPIVACAINE AND CLONIDINE VERSUS 0.5% HYPERBARIC BUPIVACAINE ALONE FOR ANAESTHESIA AND PERIOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LOWER LIMB ORTHOPAEDIC SURGERIES

bupivacaine group (group 2) and 6.6 minutes when clonidine was added(group 1). Our study indicated statistically significant faster onset of motor blockade when clonidine was added to intrathecal bupivacaine Result is consistent with the results obtained byAnil Thakur et al who concluded that intrathecal clonidine added to bupivacaine for spinal anaesthesia shortened the motor block onset time. (9) Kanazi et al (6) andSaptate M et al(2014 ) (11) also showed similar results with addition of clonidine to bupivacaine.
APPLICATION OF PLATELET RICH PLASMA (PRP) IN TREATMENT OF A CONTUSED LACERATED WOUND IN A DOG: A CLINICAL CASE

Second intention wound healing may be impaired by wound and host factors and thus more advanced therapies are required for a fast and satisfactory outcome. Platelet-rich plasma (PRP), rich in growth factors and cytokines essential for tissue repair, could improve wound healing. The use of regenerative therapies is becoming increasingly popular due to the low-invasive procedures needed to apply them. Platelet-rich plasma (PRP) is gaining interest due to its potential to stimulate and accel-erate the wound healing process. The cytokines and growth factors forming PRP play a crucial role in the healing process. The purpose of this article is to evaluate the effect of locally injected autologous PRP on second intention healing of contused lacerated wound in dog. Platelet Rich Plasma (PRP) therapy was used in treating of contused lacerated wound in an 5 years old dog. The wound edges were infiltrated with 5 ml of platelet rich plasma three times over 10 days. The wound healed completely 25 days after treatment. This clinical case indicates that autologous Platelet Rich Plasma (PRP) can be successfully used in treating of contused lacerated wound in dog.
Achieving Efficient And Privacy Preserving Cross Domain Big Data Deduplication In Cloud

: Innovation is improving every single day particularly in the field of Information Technology and information is extremely groundbreaking components. The vast volume of information produced through gadgets is a noteworthy impediment to deal with progressively. The achievement of information figuring is an essential issue amid the information movement and dispersal. Keeping in mind the end goal to accomplish compatibility, numerous application slights information encryption. This paper speaks to a worry about information security and proposes a novel information encryption approach known as Dynamic Data Encryption Strategy (DDES). This increase is drafted to amplify security insurance scope inside exchange time imperatives
Voices from across the divide: an IR perspective on employee voice

In this commentary we note there is increasing interest in the topic of employee voice, however we argue that there has been little effort to broaden our existing conceptualisations of voice which are artefacts of disparate disciplines. The siloed approach, we argue, applies in particular to the view of voice in the field of organisational behaviour (OB) which dominates much of this special issue. We explain how taking an Industrial Relations (IR) perspective on voice can add value to our understanding by looking at voice as a means to challenge management, or as a vehicle for employee self-determination
Antimicrobial Activity of Hydrogen Peroxide, Sesame and Gum Arabic against Streptococcus Mutans

Background: Dental caries is one of the most common and costly diseases in the world and causes the tooth loss in adults by cariogenic microorganism and food debris, affecting more than 90% of the population, regardless of age, sex or race. One of the strategies for preventing the caries is inhibition of bacterial growth specially S. mutans and prevention of microbial colonization. Objective and Methods: The present study was conducted to isolate, identify, studying the effect of sesame, gum Arabic (GA) and hydrogen peroxide (H 2 O 2 ) against S.mutans in vitroand determination of minimum inhibitory concentrations (MIC) by using well diffusion method. Results: We isolated 33 Streptococcus sp which were identified by morphological, biochemical characteristics and conformed by VITEK 2 system (version: 07,01) to 27.4, 24.3, 18.3, 12, 9, 6, 3% of S. mutans, S. salivaries, S. mitis,S. sanguinis, S. downei, S.oralis and S. pneumonia respectively. The H 2 O 2 was highly active compound against S. mutans gave 24.0 + 0.1. On the other hand, sesame and GA gave the moderate inhibition activity 20.0+0.2 and 17.0 + 0.8 against S. mutans , respectively. The MICs of GA, sesame oil and H 2 O 2 were used by agar well diffusion method against S. mutans gave 5 mg/ml for both GA and sesame, while gave 1.9% for H 2 O 2 . Conclusion: The present research is a preliminary attempt to investigate the antibacterial activity against S. mutans. Based on the results of the present research, the sesame, GA and H 2 O 2 can be used in toothpaste and medicine for the treatment of dental caries. However, further research is needed to identify and characterize the active molecules in sesame and GA responsible for their antimicrobial properties and to determine its potential for use in pharmaceutical manufacture.
Quantitative Trait Loci affecting the size of wing eyespots in a seasonally polyphenic butterfly 1

The afrotropical butterfly Bicyclus anynana has two strikingly different seasonal forms, with rows of conspicuous large eyespots along the wing margins in the wet season, and an overall dull brown appearance with small eyespots in the dry season. The wet season form provides a functional strategy to escape from bird attacks, while the dry season form avoids attacks from visual predators by crypsis against dry vegetation. The question of how such extreme phenotypic variation can emerge from a single genome has sparked a broad range of evo-devo research to unravel the biochemical and genetic mechanisms underlying eyespot formation. A substantial body of knowledge about the genetic and hormonal regulation of eyespot pigmentation and size determination has accumulated, most notably the strong correlation between the dynamics of ecdysteroid titres and eyespot size. These achievements often relied on a priori assumptions that were based on the function of genes and the effect of their alleles in other insects, which possibly prevented full disclosure of the components involved. A QTL analysis was performed to open new directions in eyespot formation research, since prior genetic or biochemical knowledge is not required to detect chromosomal regions harboring genes that affect variation within a trait with this approach. A cross between truncated selection lines for large and small eyespots was used for the analysis, which resulted in six chromosomes with QTLs above threshold. One QTL was close enough to potentially coincide with phantom or ecdysone receptor , which are involved in ecdysteroid synthesis and recognition respectively, some are in poorly-defined regions that may contain known candidate genes and two QTLs are in chromosomal regions without eyespot candidates. Closer examination of these newly found regions could pinpoint the genes responsible for the observed variation and provide new insights in butterfly eyespot size determination and possibly in mechanisms behind polyphenism.
GENERALIZED OSTROWSKI TYPE INEQUALITIES FOR INTERVAL VALUED FUNCTIONS AND ITS APPLICATION FOR ERROR ESTIMATION TO SOME QUADRATURE RULES

This work is devoted to study some Ostrowski type inequalities for generalized Hukukara diﬀerentiable interval valued functions. Mean valued theorem for gH-diﬀerentiable interval valued functions is also derived. Established results generalize some pioneer results in the existing state-of-art. Moreover, error estimations to quadrature rule of Riemann type, Simpson type and Trapezoidal type are obtained for interval valued functions by the application of one of the derived inequality. In addition an illustrative example is also furnished which demonstrates the viability of the hypothesis of one of our results.
ASYMMETRIC CELL CONVERGENCE-DRIVEN FIN BUD INITIATION AND PREPATTERN REQUIRES TBX5A CONTROL OF A MESENCHYMAL FGF SIGNAL

single-cell and 3D cell tracking in the zebrafish, describe a Tbx5a-dependent cell convergence pattern that is both asymmetric and topological within the fin-field lateral plate mesoderm during early fin bud initiation. We further demonstrate that a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility. Partial reduction in Tbx5a or Fgf24 levels disrupts the normal fin-field cell motility gradient and results in anteriorly biased perturbations of fin-field cell convergence and truncations in the pectoral fin skeleton, resembling aspects of the forelimb skeletal defects that define Holt-Oram Syndrome patients. This study provides a quantitative reference model for fin-field cell motility during vertebrate fin bud initiation and suggests that a pre-pattern of AP fate specification is already present in the fin-field before or during migration as perturbations to these early cell movements result in the alteration of specific fates. the fin-field 5O, S, W). This suggests that ectopic Fgf8, when introduced in a comparable spatiotemporal pattern to endogenous Fgf24, can rescue aspects of the fin initiation gene network in Fgf24 morphants. Taken together, these results demonstrate that fin-field LPM cells can migrate toward a localized Fgf source in a chemoattractive fashion during fin initiation. an early mechanism may pre-pattern the vertebrate fin AP axis prior to or during the fin-field convergence. We propose that a greater sensitivity to the levels of Tbx5a or Fgf expression in anterior fin-field cells versus posterior fin-field cells could contribute to the anteriorly biased defects observed that occur in Holt-Oram Syndrome patients.