Miracle-dz/UniFAR-FTUs huggingface dataset:
Submucous Cleft Palate Repair in Patients With 22q11.2 Deletion Syndrome

Objective: To determine whether surgical intervention for submucous cleft palate (SMCP) is more common in children with 22q11.2 deletion syndrome (22q DS) compared to children without 22q DS. Design: Retrospective chart review. Setting: Tertiary pediatric hospital and 22q11.2 DS specialty clinic. Participants: One hundred forty-two children seen at the tertiary hospital or clinic during a 20-year period (June 1999-June 2019) with documented SMCP with and without 22q DS. Main Outcome Measure: Percentage of children with SMCP with and without 22q DS requiring surgical intervention for velopharyngeal insufficiency. Results: Patients with 22q DS had a significantly higher frequency of SMCP repair than those without 22q DS (89.7% vs 32.0%, P < .001, χ2 = 37.75). The odds of requiring SMCP repair were 18.6 times higher in those with 22q DS compared to those without (odds ratio = 18.6, CI = 6.1-56.6). Conclusions: This study provides new evidence suggesting patients with 22q DS require SMCP surgical repair for velopharyngeal insufficiency at a significantly higher rate than those without 22q DS. As the majority of patients with 22q DS with SMCP require surgical intervention, future prospective studies looking at early versus late repair of SMCP in patients with 22q DS are needed to guide the surgical repair timeline in this population.
Trends and temperature response in the phenology of crops in Germany

The phenology of 78 agricultural and horticultural events from a national survey in Germany spanning the years 1951–2004 is examined. The majority of events are significantly earlier now than 53 years ago, with a mean advance of 1.1–1.3 days per decade. The mean trends for ‘true phases’, such as emergence and flowering, of annual and perennial crops are not significantly different, although more trends (78% vs. 46%) are significant for annual crops. We attempt to remove the influence of technological advance or altered farming practices on phenology by detrending the respective time series by linear regression of date (day number) on year. Subsequently, we estimate responses to mean monthly and seasonal temperature by correlation and regression in two ways; with and without removing the year trend first. Nearly all (97%) correlation coefficients are negative, suggesting earlier events in warmer years. Between 82% and 94% of the coefficients with seasonal spring and summer temperatures are significant. The conservative estimate (detrended) of mean temperature response against mean March–May temperature (−3.73 days °C−1) is significantly less than the full estimate (−4.31 days °C−1), the ‘true’ size of phenological temperature response may lie in between. Perennial crops exhibited a significantly higher temperature response to mean spring temperature than the annual crops.
Untangling the diffusion signal using the phasor transform

Separating the decay signal from diffusion‐weighted scans into two or more components can be challenging. The phasor technique is well established in the field of optical microscopy for visualization and separation of fluorescent dyes with different lifetimes. The use of the phasor technique for separation of diffusion‐weighted decay signals was recently proposed. In this study, we investigate the added value of this technique for fitting decay models and visualization of decay rates. Phasor visualization was performed in five glioblastoma patients. Using simulations, the influence of incorrect diffusivity values and of the number of b‐values on fitting a three‐component model with fixed diffusivities (dubbed “unmixing”) was investigated for both a phasor‐based fit and a linear least squares (LLS) fit. Phasor‐based intravoxel incoherent motion (IVIM) fitting was compared with nonlinear least squares (NLLS) and segmented fitting (SF) methods in terms of accuracy and precision. The distributions of the parameter estimates of simulated data were compared with those obtained in a healthy volunteer. In the phasor visualizations of two glioblastoma patients, a cluster of points was observed that was not seen in healthy volunteers. The identified cluster roughly corresponded to the enhanced edge region of the tumor of two glioblastoma patients visible on fluid‐attenuated inversion recovery (FLAIR) images. For fitting decay models the usefulness of the phasor transform is less pronounced, but the additional knowledge gained from the geometrical configuration of phasor space can aid fitting routines. This has led to slightly improved fitting results for the IVIM model: phasor‐based fitting yielded parameter maps with higher precision than the NLLS and SF methods for parameters f and D (interquartile range [IQR] for f: NLLS 27, SF 12, phasor 5.7%; IQR for D: NLLS 0.28, SF 0.18, phasor 0.10 μm2/s). For unmixing, LLS fitting slightly but consistently outperformed phasor‐based fitting in all of the tested scenarios.
Can becoming a leader change your personality? An investigation with two longitudinal studies from a role-based perspective.

Organizational research has predominantly adopted the classic dispositional perspective to understand the importance of personality traits in shaping work outcomes. However, the burgeoning literature in personality psychology has documented that personality traits, although relatively stable, are able to develop throughout one's whole adulthood. A crucial force driving adult personality development is transition into novel work roles. In this article, we introduce a dynamic, role-based perspective on the adaptive nature of personality during the transition from the role of employee to that of leader (i.e., leadership emergence). We argue that during such role transitions, individuals will experience increases in job role demands, a crucial manifestation of role expectations, which in turn may foster growth in conscientiousness and emotional stability. We tested these hypotheses in two 3-wave longitudinal studies using a quasi-experimental design. We compared the personality development of 2 groups of individuals (1 group promoted from employees into leadership roles and the other remaining as employees over time), matched via the propensity score matching approach. The convergent results of latent growth curve modeling from the 2 studies support our hypotheses regarding the relationship between becoming a leader and subsequent small, but substantial increases in conscientiousness over time and the mediating role of job role demands. The relationship between becoming a leader and change of emotional stability was not significant. This research showcases the prominence of examining and cultivating personality development for organizational research and practice. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Eukaryotic and Prokaryotic Phytochelatin Synthases Differ Less in Functional Terms Than Previously Thought: A Comparative Analysis of Marchantia polymorpha and Geitlerinema sp. PCC 7407

This paper reports functional studies on the enzyme phytochelatin synthase in the liverwort Marchantia polymorpha and the cyanobacterium Geitlerinema sp. strain PCC 7407. In vitro activity assays in control samples (cadmium-untreated) showed that phytochelatin synthase was constitutively expressed in both organisms. In the presence of 100 µM cadmium, in both the liverwort and the cyanobacterium, the enzyme was promptly activated in vitro, and produced phytochelatins up to the oligomer PC4. Likewise, in vivo exposure to 10–36 µM cadmium for 6-120 h induced in both organisms phytochelatin synthesis up to PC4. Furthermore, the glutathione (GSH) levels in M. polymorpha were constitutively low (compared with the average content in higher plants), but increased considerably under cadmium stress. Conversely, the GSH levels in Geitlerinema sp. PCC 7407 were constitutively high, but were halved under metal treatments. At odds with former papers, our results demonstrate that, as in M. polymorpha and other plants, the cyanobacterial phytochelatin synthase exposed to cadmium possesses manifest transpeptidasic activity, being able to synthesize phytochelatins with a degree of oligomerization higher than PC2. Therefore, prokaryotic and eukaryotic phytochelatin synthases differ less in functional terms than previously thought.
Co-Expression of IL-7 Improves NKG2D-Based CAR T Cell Therapy on Prostate Cancer by Enhancing the Expansion and Inhibiting the Apoptosis and Exhaustion

Chimeric antigen receptor (CAR) T-cell therapy is a promising approach in treating solid tumors but the therapeutic effect is limited. Prostate cancer is a typical solid malignancy with invasive property and a highly immunosuppressive microenvironment. Ligands for the NKG2D receptor are primarily expressed on many cancer cells, including prostate cancer. In this study, we utilized NKG2D-based CAR to treat prostate cancer, and improved the therapeutic effect by co-expression of IL-7. The results showed that NKG2D-CAR T cells performed significantly increased cytotoxicity against prostate cancer compared to non-transduced T cells in vitro and in vivo. Moreover, the introduction of the IL-7 gene into the NKG2D-CAR backbone enhanced the production of IL-7 in an antigen-dependent manner. NKG2DIL7-CAR T cells exhibited better antitumor efficacy at 16 h and 72 h in vitro, and inhibited tumor growth in xenograft models more effectively. In mechanism, enhanced proliferation and Bcl-2 expression in CD8+ T cells, decreased apoptosis and exhaustion, and increased less-differentiated cell phenotype may be the reasons for the improved persistence and survival of NKG2DIL7-CAR T cells. In conclusion, these findings demonstrated that NKG2D is a promising option for CAR T-cell therapy on prostate cancer, and IL-7 has enhanced effect on NKG2D-based CAR T-cell immunotherapy, providing a novel adoptive cell therapy for prostate cancer either alone or in combination with IL-7.
Identifying Candidate Genes for Hypoxia Adaptation of Tibet Chicken Embryos by Selection Signature Analyses and RNA Sequencing

The Tibet chicken (Gallus gallus) lives on the Qinghai–Tibet Plateau and adapts to the hypoxic environment very well. The objectives of this study was to obtain candidate genes associated with hypoxia adaptation in the Tibet chicken embryos. In the present study, we used the fixation index (Fst) and cross population extended haplotype homozygosity (XPEHH) statistical methods to detect signatures of positive selection of the Tibet chicken, and analyzed the RNA sequencing data from the embryonic liver and heart with HISAT, StringTie and Ballgown for differentially expressed genes between the Tibet chicken and White leghorn (Gallus gallus, a kind of lowland chicken) embryos hatched under hypoxia condition. Genes which were screened out by both selection signature analysis and RNA sequencing analysis could be regarded as candidate genes for hypoxia adaptation of chicken embryos. We screened out 1772 genes by XPEHH and 601 genes by Fst, and obtained 384 and 353 differentially expressed genes in embryonic liver and heart, respectively. Among these genes, 89 genes were considered as candidate genes for hypoxia adaptation in chicken embryos. ARNT, AHR, GSTK1 and FGFR1 could be considered the most important candidate genes. Our findings provide references to elucidate the molecular mechanism of hypoxia adaptation in Tibet chicken embryos.
Apelin Improves Prognostic Value of HFSS (Heart Failure Survival Score) and MAGGIC (Meta-Analysis Global Group in Chronic Heart Failure) Scales in Ambulatory Patients with End-Stage Heart Failure †

This prospective study aimed to determine the effect of adding apelin to the MAGGIC (Meta-Analysis Global Group In Chronic Heart Failure) and HFSS (Heart Failure Survival Score) scales for predicting one-year mortality in 240 ambulatory patients accepted for heart transplantation (HT) between 2015–2017. The study also investigated whether the combination of N-terminal pro-brain natriuretic peptide (NT-proBNP) with MAGGIC or HFSS improves the ability of these scales to effectively separate one-year survivors from non-survivors on the HT waiting list. The median age of the patients was 58.0 (51.50.0–64.0) years and 212 (88.3%) of them were male. Within a one year follow-up, 75 (31.2%) patients died. The area under the curves (AUC) for baseline parameters was as follows—0.7350 for HFSS, 0.7230 for MAGGIC, 0.7992 for apelin and 0.7028 for NT-proBNP. The HFSS-apelin score generated excellent power to predict the one-year survival, with the AUC of 0.8633 and a high sensitivity and specificity (80% and 78%, respectively). The predictive accuracy of MAGGIC-apelin score was also excellent (AUC: 0.8523, sensitivity of 75%, specificity of 79%). The addition of NT-proBNP to the HFSS model slightly improved the predictive power of this scale (AUCHFFSS-NT-proBNP: 0.7665, sensitivity 83%, specificity 60%), while it did not affect the prognostic strength of MAGGIC (AUCMAGGIC-NT-proBNP: 0.738, sensitivity 71%, specificity 69%). In conclusion, the addition of apelin to the HFSS and MAGGIC models significantly improved their ability to predict the one-year survival in patients with advanced HF. The MAGGIC-apelin and HFSS-apelin scores provide simple and powerful methods for risk stratification in end-stage HF patients. NT-proBNP slightly improved the prognostic power of HFSS, while it did not affect the predictive power of MAGGIC.
Practice Patterns for Eosinophilic Esophagitis Patients in Busan and Gyeongnam: A Korean Multicenter Database Study

Background/Aims The prevalence of eosinophilic esophagitis is increasing in Korea and there are few single-center studies regarding eosinophilic esophagitis in Korea. In particular, data about management for eosinophilic esophagitis are lacking. We aim to evaluate the practice patterns, including initial treatment and response, in the Busan city and Gyeongnam province area. Methods We retrospectively reviewed medical records to gain data on patient characteristics, medication, endoscopic images, and esophageal biopsy results. From January 2009 to December 2019, a total of 42 patients were diagnosed with eosinophilic esophagitis. Results The mean age was 50.7 (from 22 to 81) years and the cohort was predominantly male (78.6%, 33/42). The proton pump inhibitor was the preferred treatment as an initial trial for 64.3% (27/42) of patients, followed by swallowed topical steroids (16.7%, 7/42). Clinical improvement after proton pump inhibitor therapy was achieved in 88.9% (24/27) of patients. Two patients who did not achieve improvement showed a clinical and endoscopic response after swallowed topical steroids treatment. No patient received diet elimination or balloon dilatation therapy. Conclusions The treatment response of eosinophilic esophagitis was good in Busan city and Gyeongnam province area in Korea. Proton pump inhibitor therapy was the preferred and most effective treatment for eosinophilic esophagitis as the initial therapy.
Translocation of 13C-Assimilates in the Spring Following Fall Assimilation of 13CO2 by 'Nijisseiki' Pear (Pyrus pyrifolia Nakai)

Three-year-old 'Nijisseiki' pear (Pyrus pyrifolia Nakai) trees were treated twice with 13CO2 in October (fall). The distribution of labeled 13C within the tree during dormancy and remobilization in the following season were determined. After leaf-fall, about 63% of the total 13C recovered from the tree was distributed in the roots. At anthesis the 13C content from the previous season's organs showed a significant decrease : the aerial organs decreased by about 53% and the roots by nearly 60%. About 35% of the total 13C recovered from the trees after leaf-fall was consumed by respiration until anthesis. New shoot, flower, and root growth accounted for 8.5%, 9.9%, and 3.9% of the total 13C recovered from the tree after leaf-fall, respectively. One month after anthesis, the 13C remaining in the previous season's organs, had further decreased, having been exported to the new leaves and current shoots. The 13C remaining in the fruitlets dramatically decreased because of the abscission of sepals, petals, stamens, and partial pistils (style and stigma). New roots had the highest concentration of 13C among all new organs. These data suggest that root systems play a special role in the storage of carbohydrates in young pear trees. All organs depend on carbohydrate reserves for spring growth, especially new roots which seem to depend on reserves for a longer time.
Indigenous Lactic Acid Bacteria Isolated from Spontaneously Fermented Goat Milk as Potential Probiotics.

BACKGROUND AND OBJECTIVE Lactic Acid Bacteria (LAB) isolated from goat milk have been known to have various medicinal properties, therefore they are considered as a source of potential probiotics. This research was aimed at evaluating and identifying the LAB isolated from spontaneously fermented goat milk as potential probiotics. MATERIALS AND METHODS The fresh goat milk fermented for 4 days was serially diluted, plated on de Man Rogosa and Sharpe (MRS) agar supplemented with 1% CaCO3 as selective medium, then purified accordingly. The isolated LAB were screened for their potential to inhibit enteric pathogen bacteria using well diffusion method. Their capabilities to withstand the bile salt and acid environment were also evaluated. The production of organic acids was also assessed. The potential probiotics were identified molecularly using 16S rRNA. RESULTS The study confirmed that LAB isolated from spontaneous fermentation of goat milk was Lactobacillus plantarum based on 16S rRNA gene marker. This bacterium showed antimicrobial activity against indicator bacteria, ability to live after exposure in bile salt solution and resistance to low acidic environment. The organic acids produced by this bacterium were lactic, acetic, propionic and butyric acids. CONCLUSION This study concluded that Lactobacillus plantarum YN.1. 3 can be further investigated as potential probiotic as it showed antimicrobial activity, withstood the acidic environment and bile salt solution, as well as produced organic acids.
Incidence of Pelvic Inflammatory Disease Associated With Mycoplasma genitalium Infection: Evidence Synthesis of Cohort Study Data

Abstract We synthesized evidence from the POPI sexual-health cohort study and estimated that 4.9% (95% credible interval, .4–14.1%) of Mycoplasma genitalium infections in women progress to pelvic inflammatory disease versus 14.4% (5.9–24.6%) of chlamydial infections. For validation, we predicted PID rates in 4 age groups that agree well with surveillance data.
Alba, a Girl Who Successfully Overcomes Barriers of Intellectual Disability Through Dialogic Literary Gatherings

This article examines the biography of an 11-year-old student, Alba, who lives in a deprived social context and has an intellectual disability. With an academic proficiency 4 years behind the rest of her class, Alba was always well accepted by her classmates, but she never stood out academically. Her biography shows a turning point as a result of her participation in dialogic literary gatherings. By sharing this dialogic space, where works of classic literature are discussed and knowledge is created based on collective interpretations of the text, Alba has had the opportunity not only to learn from her classmates but also to make brilliant contributions that have sparked profound debates among her peers. Alba’s communicative biography unveils an educational action that is capable of making vulnerable students visible, not only because of what they can learn from others but also because of what they can contribute.
Exergames in people with major neurocognitive disorder: a systematic review

Abstract Purpose To systematically evaluate the efficacy of exergames in individuals with major neurocognitive disorder. Materials and methods PubMed, EMBASE and PEDro were systematically searched from inception until October 2019 for randomised and clinical controlled trials. Methodological quality of the trials was assessed with the PEDro rating scale or Risk of Bias in Nonrandomised Studies of Interventions-I (ROBINS-I), when appropriate. Grading of Recommendations Assessments, Development and Evaluation (GRADE) was used to assess the overall quality of the evidence. Results Eight trials, all of moderate to high methodological quality (i.e., PEDro score of 6 or higher or a Robins-I moderate quality score) were included. The overall quality of evidence was moderate to high according to the GRADE criteria. Improvements in gait, mobility and balance and beneficial effects on activities of daily living performance, cognitive function, fear of falls, quality of life and mood following exergaming were reported. Heterogeneity in outcome measures, intervention characteristics and included participants precluded a meta-analysis. Conclusions The current literature is of moderate to high quality and demonstrates that exergames have a wide range of physical and mental benefits in people with major neurocognitive disorder. More controlled trials are however needed to confirm the existing evidence before exergames can be recommended in treatment guidelines for people with major neurocognitive disorder. Implications for rehabilitation Exergames have many physical and mental benefits in people with major neurocognitive disorder Exergaming can enhance gait, mobility and balance in people with major neurocognitive disorder Evidence for beneficial cognitive effects of exergaming is emerging
76. Variations in the Solids-not-Fat Content of Milk. I and II

1. The solids content of fat-free milk shows little variation throughout the milking process, i.e. first and last drawn milk are of similar concentration. 2. Curves are presented showing the normal variation in the solids content of fat-free milk throughout a lactation period. These curves are influenced by the age of the cow and by pregnancy.
Evaluation of beef breeds for rangeland weaner production in Zimbabwe 2. Productivity of crossbred cows and heterosis estimates

Crossbred cows were evaluated for reproductive performance and live weight, and for pre-weaning growth and viability of progeny sired by seven unrelated breeds. They were also evaluated on overall productivity expressed as weight of weaned calf per cow mated per year, per 100 kg of cow per year and per 100 kg metabolic weight of cow per year. The cows comprised reciprocals of Africander with Mashona, Nkone, Brahman and Sussex, one-way crosses sired by Sussex out of Mashona, Nkone and Brahman dams, and by Charolais out of Africander, Mashona, Nkone, Brahman and Sussex dams. These represented sanga × sanga, sanga × zebu, Bos taurus × sanga, Bos taurus × zebu and Bos taurus × Bos taurus crossbred types. Bos taurus × zebu crosses were superior to other breed types for all the three productivity indices and for virtually all the individual components of these. There was little difference between the other four breed types in overall productivity of components of these. Differences between reciprocals were observed in sanga × sanga and sanga × zebu, cows with Africander dams being more productive than reciprocals with Mashona, Nkone and Brahman dams. The Bos taurus × Bos taurus cross was inferior in overall productivity primarily due to large cow weight and relatively low growth rate of progeny. Progeny sired by Friesian, Simmental and Brahman had higher weaning weights than those sired by Hereford, Aberdeen Angus, Africander and Tuli. Overall, heterosis was positive for all traits and averaged 0·15 for the three measures of cow productivity. Heterosis was three times higher in the Bos taurus × Bos indicus cross than in the Bos indicus crosses.