Miracle-dz/UniFAR-FTUs huggingface dataset:
Metformin Affects Cancer Regulation and Metabolism of Oral Squamous Cell Carcinoma Partially Through Upregulation of H3K27ac 

Objectives Metformin, a first-line drug that has been used for type 2 diabetes treatment, recently attracts broad attention for its therapeutic effects on diverse human cancers. However, its effect and underlying mechanisms in oral squamous cell carcinoma (OSCC) are not well known. Materials and Methods OSCC cells were used to detect the effect of metformin on cell proliferation, colony formation, cell cycle and migration in vitro. Tumor growth of nude mice was conducted to detect the effect of metformin in vivo. Western blotting and immunohistochemistry were used to investigate the effect of metformin on the expression of histone modification in vitro and vivo. The combined effect on cell proliferation and histone modification of metformin and downregulation of EZH2 was detected by CCK8 and western blotting. Additionally, RNA-seq and ChIP-seq was performed to explore the underlying mechanisms of metformin in OSCC.Results Metformin could inhibit OSCC cell proliferation and tumor growth with the increased acetylation at lysine 27 of histone H3 (H3K27ac) in vitro and vivo. The underlying mechanisms were related to cancer regulation and cancer metabolism, affected by the increased H3K27ac. Additionally, metformin could synergize with siRNA-EZH2 to inhibit OSCC cell proliferation independent on the increased H3K27ac.Conclusions Metformin could play anti-cancer role in OSCC progression, with the reprogramming of cancer regulation and metabolism partially regulated by the increased H3K27ac.
Age-specific risk factors for adverse maternal and neonatal outcomes in Xiamen, China: A population-based retrospective study

Background: Elderly mothers are increasingly in China. We are aims to explore whether association between pregnancy to delivery interval and adverse pregnancy outcomes is affected by maternal age. Methods: A population-based retrospective study was performed in Xiamen, China. Data were derived from the Medical Birth Registry of Xiamen from 2011 to 2018. Multivariable logistic regression was used to conduct multivariable analyses based on adjusting the factors to evaluate the effect of maternal age on pregnancy outcomes. Results: Among 77,859 pregnant women with specific age, gestational diabetes mellitus (GDM) risk were increased for women aged 40 years or older (42.9%; aRR, 3.84 (3.26-4.51); P < 0.001), but not for pregnant women aged less than 25 years (9.2%; aRR, 0.60 (0.54-0.68)). Increased cesarean, preterm birth, large-for-gestational age (LGA), and low birth weight risks were more pronounced for pregnant women aged 40 years or older (66.5%, 8.4%, 26.5%, and 6.7%, respectively; aRR, 3.77 (3.14-4.52), 1.26 (0.90-1.79), 1.31 (1.08-1.60), and 1.10 (0.74-1.65), respectively; all P < 0.001). Risk of Apgar < 7 at 5 minutes were increased for women < 25 years old compared with women 35 to 39 years old (0.2% vs. 0.1%; aRR, 2.05 (0.85-4.93) vs. 0.63 (0.14-2.86)). Conclusion: Advanced maternal age increased risk of adverse pregnancy outcomes. The risk ratio of GDM, cesarean, preterm birth, LGA, and low birth weight is higher, which suggests pregnant women should guard against related risk factors and choose an appropriate mode of production. Furthermore, pregnant women should choose an ideal age for pregnancy to make themselves and child healthy.
Experimental spinal trauma studies in the human and monkey cadaver

Compression studies were conducted on the ligamentous thoracolumbar spines of fresh human male cadavers. For comparison, forces were applied to the posterior upper thoracic region of intact seated cadavers. Since thoracolumbar flexion injury routinely involves ligament failure and vertebral body wedge compression fractures, studies were conducted on single vertebral bodies and isolated ligaments. Similar studies were conducted in isolated monkey ligaments. The intact and ligamentous thoracolumbar spines failed predominantly in the region of the thoracolumbar junction at forces from 1113-5110 N. For both the human and monkey cadavers, the anterior longitudinal ligament was the strongest. The human ligaments were 2-5 times stronger than those of the monkey. For the covering abstract of the conference see HS-036 716. (Author/TRRL)
Study of Man-Weapon Reaction Forces Applicable to the Fabrication of a Standard Rifle Firing Fixture.

Abstract : A study was conducted of the man-weapon interaction force relationship to define the parameters to be incorporated in the design of a universal small arms test fixture, that simulates man as a flexible mount. This report contains the results of Phase I of the program, which is to provide the engineering data and preliminary drawings required for the fabrication of a prototype test fixture. To demonstrate the feasibility of designing a universal mount fixture, a three degree of freedom mathematical model was developed that simulates the man and weapon as a coupled dynamical system. A sensitivity analysis was performed on both analog and digital computers to determine which of the system parameters are critical to the design of the mount and to obtain bounds on them. The mathematical simulation was supported by an extensive test firing program, involving shooters of various sizes firing the M16 rifle and the M79 and M203 grenade launchers. In these tests the shoulder reaction force and the dynamical motions of the man-weapon system were recorded.
Performance Evaluation of Water Delivery System for Command Area of Amarpura Minor of Som-Kagdar Irrigation Project, Rajasthan

This study examines water delivery performance of the Amarpura minor, which is located on left main canal of Som-kagdar irrigation project. Outlets wise performance was evaluated, using the adequacy, equity, dependability and relative water supply indicators. These indicators were calculated for the fifteen outlets for the 5-month irrigation period of Rabi season (2004–05), using measured water deliveries and calculated crop water requirements. Digital current meter was used to measure the outlet discharge during the season. Crop water requirements were calculated using CROPWAT.
Low threshold organic and quantum dot nanobeam lasers

Lasers in the visible spectrum have many applications including sensing, medical, and entertainment applications. Traditional semiconductors face challenges that limit their ability to create lasers for the visible spectrum. Organic materials and quantum (lots are an attractive alternative for visible lasers due to their broad, tunable emission and deposition using fabrication techniques of low complexity. These materials have been used to demonstrate low lasing thresholds, and we hope to improve upon them with a novel design, paving the way towards electrically pumped and continuous wave operation lasing. In this thesis we couple the use of organic materials and quantum dots with one dimensional nanobeam photonic crystal cavities to design lasers for the visible spectrum. We cover the theory behind generation of optical gain and lasing as well as the theory of photonic crystals. We outline a strategy for designing laser cavities using the chosen gain materials. Finally, we demonstrate a low lasing threshold of 4.2 [mu]J/cm2 for our organic lasers.
Determining timing for isothermal pulsed-bias S-parameter measurements

S-parameters measured under pulsed conditions are shown to vary from their steady-state values with pulse measurement width and pulse repetition rate. A method is presented for determining suitable timing for isothermal, pulsed-bias, pulsed-RF, S-parameter measurement of GaAs devices. Variation of S-parameters with wafer temperature and with measurement duration and duty cycle are correlated.
Aeroelastic Response and Stability of Tiltrotors with Elastically-Coupled Composite Rotor Blades

There is a potential for improving the performance and aeroelastic stability of tiltrotors through the use of elastically-coupled composite rotor blades. To study the characteristics of tiltrotors with these types of rotor blades it is necessary to formulate a new analysis which has the capabilities of modeling both a tiltrotor configuration and an anisotropic rotor blade. Background for these formulations is established in two preliminary investigations. In the first, the influence of several system design parameters on tiltrotor aeroelastic stability is examined for the high-speed axial flight mode using a newly-developed rigid-blade analysis with an elastic wing finite element model. The second preliminary investigation addresses the accuracy of using a one- dimensional beam analysis to predict frequencies of elastically-coupled highly-twisted rotor blades. Important aspects of the new aeroelastic formulations are the inclusion of a large steady pylon angle which controls tilt of the rotor system with respect to the airflow, the inclusion of elastic pitch-lag coupling terms related to rotor precone, the inclusion of hub-related degrees of freedom which enable modeling of a gimballed rotor system and engine drive-train dynamics, and additional elastic coupling terms which enable modeling of the anisotropic features for both the rotor blades and the tiltrotor wing. Accuracy of the new tiltrotor analysis is demonstrated by a comparison of the results produced for a baseline casewith analytical and experimental results reported in the open literature. Two investigations of elastically tailored blades on a baseline tiltrotor are then conducted. One investigation shows that elastic bending-twist coupling of the rotor blade is a very effective means for increasing the flutter velocity of a tiltrotor, and the magnitude of coupling required does not have an adverse effect on performance or blade loads. The second investigation shows that passive blade twist control via elastic extension-twist coupling of the rotor blade has the capability of significantly improving tiltrotor aerodynamic performance. This concept, however, is shown to have, in general, a negative impact on stability characteristics.
EVALUATION OF THE EVALUE MODEL FOR ESTIMATING MANNING'S ROUGHNESS IN FURROW IRRIGATION

Manning's roughness coefficient is a key parameter in the design and evaluation of furrow irrigation. Despite its importance, estimation of this parameter in surface irrigation is difficult, particularly in furrow irrigation. In this study, the EVALUE model was used for estimating Manning's roughness coefficient in furrow irrigation. The EVALUE model is based on volume balance and has been developed for estimating Manning's roughness coefficient in surface irrigation. EVALUE estimates both infiltration parameters and Manning's roughness coefficient simultaneously. The main input for the model is depth of flow along the furrow at different times. Evaluation of EVALUE was performed by comparing measured and simulated advance and recession data using SIRMOD software. The estimated values of Manning's roughness coefficient ranged between 0.02 and 0.102. The estimated values of Manning's roughness coefficient by EVALUE were somewhat different from the suggested SCS values, particularly during the first irrigation, but comparable with the results shown by other studies. Copyright © 2011 John Wiley & Sons, Ltd.
Reliable and enhanced performances of sub-0.1 /spl mu/m pMOSFETs doped by low biased plasma doping

For the first time, we include low biased plasma doping (LB PLAD) technique for extensions doping within an industrial 0.13 /spl mu/m CMOS process. By comparing to the Ultra-Low Energy Ion Implantation (B/sup +/ and BF/sub 2//sup +/) technique (ULE I/I), plasma doped devices exhibits improved Short Channel Effect (SCE) and subthreshold performances mostly attributed to the good junction characteristics (tradeoff junction depth (X/sub j/)/sheet resistance (R/sub s/)).
On-Orbit Performance of the COS Detectors

The Cosmic Origins Spectrograph includes two microchannel plate de- tectors. The FUV channel uses a two-segment cross delay line (XDL) device, while the the NUV channel uses a MAMA, similar to those used by other HST instruments. Since SM4, both detectors have been characterized in detail ,u sing data collected as part of specific calibration programs and in the course of normal science observations. We will describe the on-orbit performance of both detectors since the installation of COS, and describe ongoing detector characterization work. 1. Overview The Cosmic Origins Spectrograph uses a separate detector fo re ach of its two channels. The performance of both detectors has been monitored extensively since the installation of COS during SM4 in May 2009. For the FUV channel, an open-faced microchannel plate (MCP) detector with a cross delay line anode (XDL) is used. The layout is similar to the detectors used for the Far Ultraviolet Spectroscopic Explorer (FUSE), containing two independently-controlled 85 ! 10 mm segments placed end-to-end with a small gap between them. The MCPs are curved to match the focal surface of the spectrograph. A CsI photocathode on the front of the MCPs provides sensitivity in the FUV from below 900 ˚ o" 1750 ˚ Photons reaching either MCP generate a cloud of " 10 7 electrons which is collected by the anode. The position of the charge cloud on each segment is digitized to 14 bits in the spectral direction (X) and 10 bits in the cross-dispersion direction (Y), giving a digitized region of 16384 ! 1024 pixels, each 6 ! 24 µm; in addition, a 5 bit pulse height (total charge collected by the anode) is calculated. The active area of the MCP covers approximately 14,000 ! 400 pixels, and a typical science spectrum covers the full active area in X, and < 50 pixels in Y. Details of the FUV detector system are discussed by McPhate et al. (2000) and
Market potential as an indicator for the size of a new relocated football arena: The case KAA Gent a Belgian professional football team

The place of Gent in the urban system is that of a regional city with high centrality. This means that consumer-oriented services with a high threshold, such as a professional football team, reach their threshold in the city. In the case of professional football a functional substitution has taken place and the top team is located in Brugge The service area of Bruges reaches almost up to Gent and the E40 highway reduces the time-distance. The new location of the stadium is near the main highway. The question is of the market potential of the clubs is large enough to attract more attendances.
The NOL Large Scale Gap Test. III. Compilation of Unclassified Data and Supplementary Information for Interpretation of Results

Abstract : The objectives of this report are to bring up to date the compilations of all unclassified NOL large-scale gap test (LSGT) results, to describe exactly the present standardized test, and to review or report all NOL studies made on the test or modifications of it. The topics presented included standardized test procedure, best test calibration, effect of temperature and porosity on sensitivity, and the effect on test values of modifying the test. A comparison between the NOL large scale and small scale gap test values is given, and also the relationship of the former to the wedge test data. Finally an appendix is devoted to the compilation of critical diameter (dc) measurements and to showing that there is no general relationship between the LSGT results and dc. (Author)
Analysis of Platelet Counts and Platelet-Derived Growth Factor-Bb Levels in Platelet Rich Plasma Produced with Edta as Anticoagulant in Three Different Centrifugation Methods

Background: Platelet rich plasma (PRP) is an autologous product made of whole blood through centrifugation process producing high platelet concentrate in a small volume of plasma. This high platelet concentrate can lead to high growth factor levels that play important roles in the nature of thrombosis, hemostasis and wound healing. PRP has been widely used in clinical setting, however standardized procedure of PRP production has been lacking, mainly the procedure related to duration and speed of centrifugation, and also anticoagulant used. Aim: To analyze the difference between platelet counts and PDGF-BB levels in PRP produced from various preparation methods (centrifugation speed and duration), using Ethylenediaminetetraacetic Acid /EDTA as anticoagulant. Method: This study used experimental laboratory design, involving 34 healthy volunteers that met inclusion criteria. These subjects were divided into three groups with different centrifugation methods that adopted from previous study. Results: The platelet counts was found in group 1, 2, and 3 with an increase of, 2,69, 3,69, and 2,53 times from the initial platelet counts respectively and there was significant difference between platelet counts before and after treatment on three groups that used EDTA (p=0,000, p=0,003, and p=0,002 for group 1, 2 and 3 respectively). PDGF-BB levels in this group was also higher than the remaining groups. Conclusion: The highest platelet counts and PDGF-BB levels was found in PRP with EDTA produced from first spin at 2800 RPM in five minutes, and second spin at 3800 RPM in seven minutes. This study suggests further research on qualitative assessments of platelets and PDGF-BB resulted from various preparation methods (centrifugation and anticoagulant usage).
Original Research: Oral Care as Prevention for Nonventilator Hospital-Acquired Pneumonia

ABSTRACT Background: Nonventilator hospital-acquired pneumonia (NV-HAP) presents a serious and largely preventable threat to patient safety in U.S. hospitals. There is an emerging body of evidence on the effectiveness of oral care in preventing NV-HAP. Purpose: The primary aim of this study was to determine the effectiveness of a universal, standardized oral care protocol in preventing NV-HAP in the acute care setting. The primary outcome measure was NV-HAP incidence per 1,000 patient-days. Methods: This 12-month study was conducted on four units at an 800-bed tertiary medical center. Patients on one medical and one surgical unit were randomly assigned to receive enhanced oral care (intervention units); patients on another medical and another surgical unit received usual oral care (control units). Results: Total enrollment was 8,709. For the medical control versus intervention units, oral care frequency increased from a mean of 0.95 to 2.25 times per day, and there was a significant 85% reduction in the NV-HAP incidence rate. The odds of developing NV-HAP were 7.1 times higher on the medical control versus intervention units, a significant finding. For the surgical control versus intervention units, oral care frequency increased from a mean of 1.18 to 2.02 times per day, with a 56% reduction in the NV-HAP incidence rate. The odds of developing NV-HAP were 1.6 times higher on the surgical control versus intervention units, although this result did not reach significance. Conclusions: These findings add to the growing body of evidence that daily oral care as a means of primary source control may have a role in NV-HAP prevention. The implementation of effective strategies to ensure that such care is consistently provided warrants further study. It's not yet known what degree and frequency of oral care are required to effect favorable changes in the oral microbiome during acute care hospitalization. The authors examined the effectiveness of a universal, standardized oral care protocol in preventing nonventilator hospital-acquired pneumonia in the acute care setting.
A study of undergraduate students' alternative conceptions of the Earth's interior using drawing tasks

Learning fundamental geoscience topics such as plate tectonics, earthquakes, and volcanoes requires students to develop a deep understanding of the conceptual models geologists use when describing the structure and dynamics of Earth’s interior. Despite the importance of these mental models underlying much of the undergraduate geoscience curriculum, surprisingly little research related to this complex idea exists in the discipline-based science education research literature. To better understand non-science-majoring undergraduates' conceptual models of Earth’s interior, student-generated drawings and interviews were used to probe student understanding of the Earth. Ninety-two semi-structured interviews were conducted with non-science-major college students at the beginning of an entry-level geology course at a large Midwestern university. Students were asked to draw a picture of Earth’s interior and provide think-aloud explanations of their drawings. The results reveal that students hold a wide range of alternative conceptions about Earth, with only a small fraction having scientifically accurate ideas. Students’ understandings ranged from conceptualizing Earth’s interior as consisting of horizontal layers of rock and dirt, to more sophisticated views with Earth’s interior being composed of concentric layers with unique physical and chemical characteristics. Processes occurring within Earth, such as "convection," were rarely mentioned or explained. These results provide a first-steps basis from which to further explore college students’ thinking and contribute to the growing body of knowledge on earth science teaching and geoscience education research. 2013 Honduran students’ conceptions of This qualitative study used participant-generated drawings and interviews to assess students’ conceptions of Earth’s Results suggest that Honduran students, aged 9-14, held varying levels of understanding regarding this science concept. Many exhibited alternative conceptions of Earth's interior, including that it contained nonconcentric layers; physical objects, such as houses; and mythical creatures.