Miracle-dz/UniFAR-FTUs huggingface dataset:
A fish‐based multi‐metric assessment index in the Karun River basin, Iran

Large river systems are one of the most important water resources for human societies. However, the ecological integrity of large rivers has been altered greatly by human activities. To monitor and manage these ecosystems, multimetric indices (MMI) are considered as efficient tools. This study aimed to develop and validate a fish‐based multimetric index for the Karun River basin, Iran (Karun fish‐based multi‐metric index [KFMMI]). Eighteen rivers and 54 sites in the basin were sampled in July–August 2019, and physico‐chemical and habitat characteristics were used to identify reference sites based on principal components analysis (PCA). Of the 54 sites, 14, 26, and 14 sites were classified as least, moderate, and most disturbed sites, respectively. Fifty‐four candidate metrics were evaluated for range, responsiveness, and redundancy with other metrics. This resulted in the identification of eight metrics (relative abundance of native and endemic taxa, relative richness of migratory taxa, relative richness of Leuciscidae taxa, relative richness of herbivorous taxa, relative abundance of cyprinid taxa, relative richness of vegetative inhabitant taxa, relative abundance of slow water flow, and relative richness of edge inhabitant taxa) that informed on species richness and composition, migratory status, functional feeding groups, and habitat preferences. The KFMMI showed excellent performance in separating least, moderate, and most disturbed sites in our study area. Regarding water quality, the KFMMI was classified 16, 5, and 29 sites as good, moderate, and bad, respectively. The discrimination efficiency of KFMMI was 81.6%, which makes it an effective management tool for directing restoration actions at most disturbed sites and intensifying protection of least disturbed sites.
Endometrial Cut Off Thickness as Predictor of Endometrial Pathology in Perimenopausal Women with Abnormal Uterine Bleeding: A Cross-Sectional Study

Purpose We aim to determine the predictive value of endometrial thickness by transvaginal ultrasonography (TVS) in diagnosing endometrial pathology and to evaluate whether Doppler complements its diagnostic efficacy in perimenopausal women with abnormal uterine bleeding. Methods This cross-sectional observational study was conducted among 70 perimenopausal women with AUB who underwent TVS measurement of endometrial thickness (ET) and Doppler flow indices followed by endometrial sampling and histopathological examination (HPE). Results In HPE, 51 (73%) women had normal diagnosis while 19 (27%) women had neoplastic histology either benign or malignant. They were categorised into group I and group II, respectively. There was a significant difference in age (P=0.001) and incidence of obesity (P=0.01) between the two groups. The ETs measured in group I and group II were 7.89 ± 2.62 mm and 14.07 ± 3.96 mm, respectively, with significant difference (P < 0.001). A TVS-ET of 10.5 mm had the highest sensitivity and specificity of 89.5% and 86.3%, respectively, PPV of 70.68%, NPV of 95.68%, LR+ of 6.52, and LR− of 0.12. Doppler flow velocimetric study of endometrial and uterine vessels did not demonstrate a significant difference. Conclusions Women in perimenopause with AUB should be offered to undergo endometrial sampling for histopathological examination if TVS ET ≥10.5 mm. The coexisting risk factors especially higher age (>45 years) and obesity (BMI>30) significantly escalate the chances of developing endometrial pathology.
INTEGRATING THE ChE CURRICULUM VIA A RECURRING LABORATORY ChE laboratory

221 Engineering education literature has found active learning to be beneficial. A review by Prince[1] found support for collaborative learning, cooperative learning, and problem-based learning (PBL), all considered forms of active learning. Collaborative and cooperative learning refer to students working in groups toward a common goal, with cooperative learning further specifying that students are evaluated as individuals. PBL has several possible implementation schemes, but in general all types pose problems at the beginning of instruction and they tend to rely on selfdirected learning by the students. Considering the evidence for the positive effects of active learning, many faculty have begun to adopt these teaching methods in the classroom. In a 2011 study of chemical engineering and electrical engineering faculty, 82.1% of the faculty members have used or are using one or more of the 12 Research Based Instructional Strategies (RBIS) as outlined by Borrego, et al.[2] with 61% utilizing active learning. Although the response rate to the survey was low, it is qualitatively encouraging to see evidence of RBIS being implemented in the classroom.
Secure and Anonymous Three-Factor Authentication Scheme for Remote Healthcare Systems

Wireless medical sensor networks (WMSNs) play a significant role in increasing the availability of remote healthcare systems. The vital and physiological data of the patient can be collected using the WMSN via sensor nodes that are placed on his/her body and then transmitted remotely to a healthcare professional for proper diagnosis. The protection of the patient’s privacy and their data from unauthorized access is a major concern in such systems. Therefore, an authentication scheme with a high level of security is one of the most effective mechanisms by which to address these security concerns. Many authentication schemes for remote patient monitoring have been proposed recently. However, the majority of these schemes are extremely vulnerable to attacks and are unsuitable for practical use. This paper proposes a secure three-factor authentication scheme for a patient-monitoring healthcare system that operates remotely using a WMSN. The proposed authentication scheme is formally verified using the Burrows, Abadi and Needham’s (BAN) logic model and an automatic cryptographic protocol verifier (ProVerif) tool. We show that our authentication scheme can prevent relevant types of security breaches in a practical context according to the discussed possible attack scenarios. Comparisons of the security and performance are carried out with recently proposed authentication schemes. The results of the analysis show that the proposed authentication scheme is secure and practical for use, with reasonable storage space, computation, and communication efficiency.
Inhibition of Non-Small Cell Lung Cancer Proliferation and Survival by Rosemary Extract Is Associated with Activation of ERK and AMPK

Non-small cell lung cancer (NSCLC) represents an aggressive form of lung cancer which often develops resistance to chemo- and radiotherapy emphasizing a need to identify novel treatment agents to combat it. Many plants contain compounds with anti-inflammatory, antimicrobial, antidiabetic, and anticancer properties and some plant-derived chemicals are used in the treatment of cancer. A limited number of in vitro and in vivo animal studies provide evidence of anticancer effects of rosemary (Rosmarinus officinalis) extract (RE); however, no studies have explored its role in H1299 NSCLC cells, and its underlying mechanism(s) of action are not understood. The current study examined the effects of RE on H1299 cell proliferation, survival, and migration using specific assays. Additionally, immunoblotting was used to investigate the effects of RE treatment on signalling molecules implicated in cell growth and survival. Treatment with RE dose-dependently inhibited H1299 proliferation with an IC50 value of 19 µg/mL. Similarly, RE dose-dependently reduced cell survival, and this reduction correlated with increased levels of cleaved poly (ADP-ribose) polymerase (PARP), a marker of apoptosis. RE was also able to inhibit cell migration as assessed with a wound healing assay. These cellular effects of RE were associated with an increase in phosphorylated levels of extracellular signal-regulated kinase (ERK), AMP-activated protein kinase (AMPK), and its downstream targets ACC, the mTORC1 protein raptor, and decreased p70S6K phosphorylation. More studies are required to fully examine the effects of RE against NSCLC.
Training-Associated Superior Visuomotor Integration Performance in Elite Badminton Players after Adjusting for Cardiovascular Fitness

Badminton is recognized as the fastest racket sport in the world based on the speed of the birdie which can travel up to 426 km per hour. On the badminton court, players are not only required to track the moving badminton birdie (visual tracking and information integration) but also must anticipate the exact timing to hit it back (temporal estimation). However, the association of training experience related to visuomotor integration or temporal prediction ability remains unclear. In this study, we tested this hypothesis by examining the association between training experience and visuomotor performances after adjusting for age, education, and cardiovascular fitness levels. Twenty-eight professional badminton players were asked to perform a compensatory tracking task and a time/movement estimation task for measuring visuomotor integration and temporal prediction, respectively. Correlation analysis revealed a strong association between training experience and performance on visuomotor integration, indicating badminton training may be promoted to develop visuomotor integration ability. Furthermore, the regression model suggests training experience explains 32% of visuomotor integration performances. These behavioral findings suggest badminton training may facilitate the perceptual–cognitive performance related to visuomotor integration. Our findings highlight the potential training in visuomotor integration may apply to eye–hand coordination performance in badminton sport.
Kişilik Özellikleri Ve Sosyal Ağ Sitesi Kullanım Alışkanlıkları: Üniversite Öğrencileri Üzerine Bir Araştırma-Personality Traits And Social Network Sites Usage Habits: A Research On University Students

Arastirmanin amaci, bireylerin sosyal ag sitelerini kullanim aliskanliklarini incelemek, kisilik ozelliklerinin bireylerin sosyal ag sitesi kullanimi ile iliskisini ve sosyal ag sitesi uyeligi itibariyle bireyler arasi kisilik farkliliklarini ortaya koyabilmektir. Bu kapsamda 15-24 yas araliginda yer alan ve aktif olarak sosyal ag sitelerini kullanan 350 universite ogrencisi ile nicel bir arastirma gerceklestirilmistir. Arastirma sonuclari, sosyal ag sitelerinde gunluk gecirilen ortalama sure ile Uyumluluk ve Deneyimlere Aciklik kisilik boyutuna iliskin ortalama puanlar arasinda anlamli ve dogrusal bir iliski oldugunu gostermistir. Erkek katilimcilarin sosyal ag sitelerinde gecirdikleri gunluk ortalama surenin kadin katilimcilardan anlamli olarak farkli oldugu tespit edilmistir. Bireylerin kisilik ozelliklerine iliskin ortalama puanlarinin sosyal ag sitesi uyeligi itibariyle anlamli olarak farkli oldugu anlasilmistir.
STUDY OF THE EFFECT OF CHITOSAN EXTRACTED FROM THE MUSHROOM ON THE EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN MALE RABBITS

The present study aimed to identify the therapeutic evaluation of chitosan extracted from the fungus cushroom and pure chitosan on glucose and lipid profile in the blood of 35 male rabbits with hyperlipidemia induced experimentally by cholesterol. The tests included estimation of glucose levels, total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, and very low-density lipoproteins. hyperlipidemia was induced in the male rabbits used in the study which was administered orally with cholesterol 150mg/kg body weight for a week. rabbits were divided into seven groups: control, cholesterol, pure chitosan, mushroom chitosan, cholesterol and pure chitosan, cholesterol and mushroom chitosan and cholesterol and simvastatin. The results of the study showed, the hyperlipidemia induced experimentally resulted a significant increase (P<0.05) in TC, TG, LDL, and VLDL, while no significant difference in HDL compared with control group, on the otherwise the glucose level significantly increase than control. Also, groups of animals treatment with pure chitosan and mushroom chitosan showed a significant decrease (P<0.05) in glucose, TC, TG, LDL, and VLDL, and no significant difference in HDL compared with control group. While, the groups showed treatment with cholesterol and pure chitosan, cholesterol and mushroom chitosan, cholesterol and simvastatin a significant decrease (P<0.05) in glucose, TC, TG, LDL, and VLDL, and a significant increase (P<0.05) in HDL compared with the cholesterol group. The research study revealed that chitosan extracted from mushroom can control the levels of fat concentrations and their complications, in addition to its important role in biochemical variables, and treatment of most disease cases, especially cardiovascular disease.
A cross sectional study on prevalence and risk factors of retinopathy of prematurity in a tertiary care centre in Chidambaram, Tamil Nadu

Background: The incidence of ROP in India was reported to be 38 to 47%. The emergence of ROP was the end result of complex interaction between multiple factors. Objectives: To find out the incidence of retinopathy of prematurity. To identify the risk factors which predispose to the development and progression of retinopathy of prematurity. Methodology: The present study was hospital based descriptive study carried out in the department of ophthalmology, Rajah Muthiah Medical College and Hospital, Annamalai University, Chidambaram between January 2020 to March 2021. The study was carried out among infants born during the study period. They were screened for the emergence of ROP. All the sociodemographic and maternal related variables have been recorded on a proforma. The master chart was then created and analysed using SPSS version 26. Results: Out of the 86 study participants, 53.5% were male, 50% belonged to gestational age of > 32 weeks, 73.3% were weighted less than or equal to 1500 grams and 26.7% were >1500 grams, 57% participants’ mothers had normal delivery, 83.7% of the mother had singleton delivery and 76.7% required oxygen supplementation. Among infants with birth weight less than or equal to 1500 grams, 23.8% had ROP, infants whose mother had gestational age <30 weeks, 33.3% infants who received oxygen supplementation had ROP. Among the study infants who had sepsis 58.3% had ROP. In the present study participants who received exchange transfusion 59.3% had developed ROP, variables like phototherapy, mode of delivery and twin delivery were not statistically significant. Conclusion: The prevalence of retinopathy of prematurity was found to be on the higher side in the study population. Lower birth weight, lower gestational age, presence of RDS, history of sepsis and exchange transfusions were found to be the risk factors associated with ROP.
Microfluidic-Based Droplets for Advanced Regenerative Medicine: Current Challenges and Future Trends

Microfluidics is a promising approach for the facile and large-scale fabrication of monodispersed droplets for various applications in biomedicine. This technology has demonstrated great potential to address the limitations of regenerative medicine. Microfluidics provides safe, accurate, reliable, and cost-effective methods for encapsulating different stem cells, gametes, biomaterials, biomolecules, reagents, genes, and nanoparticles inside picoliter-sized droplets or droplet-derived microgels for different applications. Moreover, microenvironments made using such droplets can mimic niches of stem cells for cell therapy purposes, simulate native extracellular matrix (ECM) for tissue engineering applications, and remove challenges in cell encapsulation and three-dimensional (3D) culture methods. The fabrication of droplets using microfluidics also provides controllable microenvironments for manipulating gametes, fertilization, and embryo cultures for reproductive medicine. This review focuses on the relevant studies, and the latest progress in applying droplets in stem cell therapy, tissue engineering, reproductive biology, and gene therapy are separately evaluated. In the end, we discuss the challenges ahead in the field of microfluidics-based droplets for advanced regenerative medicine.
Assessment of Oral Health Care Needs among Fishermen Living in North Chennai, India – A Cross Sectional Study

Introduction: Studies conducted among fishermen shows that there was a high prevalence rate in Oral mucosal lesions. However, data on oral health care needs among fisherman is scarce. Hence this was undertaken to obtain a data that can be used to plan programmes for the prevention and treatment of such oral mucosal lesions in the fishermen. Materials and Methods: A study was carried out among 71 fishermen after obtaining clearance from the institutional ethical committee and concerned authorities. A self administered questionnaire is distributed among the study group comprising questions relating to personal history and deleterious habits. Clinical examination was carried out using mouth mirror, explorer and under proper illumination. Oral health examination was done using WHO Basic Oral health Assessment proforma, 2013. Data collected and analysed statistically using SPSS software. Results: Among the 71 fishermen, 56(78.9%) were males and 15 (21.1 %) were females. In the study population, 44(62%) were tobacco chewers, 39(54.9%) were snuff users, 24(33.8%) were alcohol consumers and 19(26.8%) were smokers. Smokeless tobacco (41.5%) was the most common deleterious habit after which by alcohol consumption (33.8%) and smoking (26.8%). The prevalence of oral mucosal lesions was 20.8%. It was found that statistically significant association existed between the deleterious habits and leukoplakia. Conclusion: According to the our study, the prevalence of oral mucosal lesions was 20.8% among the fishermen who had a clear association with deleterious habits such as tobacco chewing, smoking, alcohol consumption and snuff.
A New Angle Measurement in Translabial Ultrasound as an Adjunct for the Diagnosis of Pelvic Organ Prolapse

The aim of this study was to compare the data obtained by a pelvic organ prolapse quantification (POP-Q) examination with the translabial ultrasound (TLUS) quantification of prolapse, using a new method of angle measurement. We analyzed the TLUS and POP-Q exam findings of 452 patients with symptoms of POP. The POP-Q system was used for clinical staging. TLUS was performed both at rest, and during the Valsalva maneuver after proper preparation. A horizontal reference line was drawn through the inferior margin of the symphysis pubis and the levator plate connected to the rectal ampulla, and the difference was calculated between the rest and the Valsalva maneuver. The Spearman’s correlation coefficient of agreement between the TLUS and the clinical POP-Q staging was used for statistical analysis. There was a weak degree of correlation between the POP-Q findings for the Ap parameter and our new angle measurement (rho = 0.17, p < 0.001). Thus, POP staging in conjunction with TLUS with this new angle measurement shows better agreement for the diagnosis of POP than POP-Q staging alone.
SRAM-Based PUF Reliability Prediction Using Cell-Imbalance Characterization in the State Space Diagram

This work proposes a methodology to estimate the statistical distribution of the probability that a 6T bit-cell starts up to a given logic value in SRAM memories for PUF applications. First, the distribution is obtained experimentally in a 65-nm CMOS device. As this distribution cannot be reproduced by electrical simulation, we explore the use of an alternative parameter defined as the distance between the origin and the separatrix in the bit-cell state space to quantify the mismatch of the cell. The resulting distribution of this parameter obtained from Monte Carlo simulations is then related to the start-up probability distribution using a two-component logistic function. The reported results show that the proposed imbalance factor is a good predictor for PUF-related reliability estimation with the advantage that can be applied at the early design stages.
Biodegradation of Alprazolam in Pharmaceutical Wastewater Using Mesoporous Nanoparticles-Adhered Pseudomonas stutzeri

The release of pharmaceutical wastewaters in the environment is of great concern due to the presence of persistent organic pollutants with toxic effects on environment and human health. Treatment of these wastewaters with microorganisms has gained increasing attention, as they can efficiently biodegrade and remove contaminants from the aqueous environments. In this respect, bacterial immobilization with inorganic nanoparticles provides a number of advantages, in terms of ease of processing, increased concentration of the pollutant in proximity of the cell surface, and long-term reusability. In the present study, MCM-41 mesoporous silica nanoparticles (MSN) were immobilized on a selected bacterial strain to remove alprazolam, a persistent pharmaceutical compound, from contaminated water. First, biodegrading microorganisms were collected from pharmaceutical wastewater, and Pseudomonas stutzeri was isolated as a bacterial strain showing high ability to tolerate and consume alprazolam as the only source for carbon and energy. Then, the ability of MSN-adhered Pseudomonas stutzeri bacteria was assessed to biodegrade alprazolam using quantitative HPLC analysis. The results indicated that after 20 days in optimum conditions, MSN-adhered bacterial cells achieved 96% biodegradation efficiency in comparison to the 87% biodegradation ability of Pseudomonas stutzeri freely suspended cells. Kinetic study showed that the degradation process obeys a first order reaction. In addition, the kinetic constants for the MSN-adhered bacteria were higher than those of the bacteria alone.
Temporal Quantitative Phosphoproteomics Profiling of Interleukin-33 Signaling Network Reveals Unique Modulators of Monocyte Activation

Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses. Aberrant IL-33 signaling has been demonstrated to play a defensive role against various infectious and inflammatory diseases. Although the signaling responses mediated by IL-33 have been previously reported, the temporal signaling dynamics are yet to be explored. To this end, we applied quantitative temporal phosphoproteomics analysis to elucidate pathways and proteins induced by IL-33 in THP-1 monocytes. Employing a TMT labeling-based quantitation and titanium dioxide (TiO2)-based phosphopeptide enrichment strategy followed by mass spectrometry analysis, we identified and quantified 9448 unique phosphopeptides corresponding to 3392 proteins that showed differential regulation. Of these, 171 protein kinases, 60 phosphatases and 178 transcription factors were regulated at different phases of IL-33 signaling. In addition to the confirmed activation of canonical signaling modules including MAPK, NFκB, PI3K/AKT modules, pathway analysis of the time-dependent phosphorylation dynamics revealed enrichment of several cellular processes, including leukocyte adhesion, response to reactive oxygen species, cell cycle checkpoints, DNA damage and repair pathways. The detailed quantitative phosphoproteomic map of IL-33 signaling will serve as a potentially useful resource to study its function in the context of inflammatory and pathological conditions.