Miracle-dz/UniFAR-FTUs huggingface dataset:
Polymorphisms in the DNA Repair Gene XRCC1 and Breast Cancer 1

X-ray repair cross complementing group 1 ( XRCC1 ) encodes a protein involved in base excision repair. We examined the association of polymorphisms in XRCC1 (codon 194 Arg 3 Trp and codon 399 Arg 3 Gln) and breast cancer in the Carolina Breast Cancer Study, a population- based case-control study in North Carolina. No association was observed between XRCC1 codon 194 genotype and breast cancer, and odds ratios (ORs) were not modified by smoking or radiation exposure. A positive association for XRCC1 codon 399 Arg/Gln or Gln/Gln genotypes compared with Arg/Arg was found among African Americans (253 cases, 266 controls; OR 5 1.7, 95% confidence interval, 1.1– 2.4) but not whites (386 cases, 381 controls; OR 5 1.0, 95% confidence interval, 0.8–1.4). Among African-American women, ORs for the duration of smoking were elevated among women with XRCC1 codon 399 Arg/Arg genotype (trend test; P < 0.001) but not Arg/Gln or Gln/Gln ( P 5 0.23). There was no difference in OR for smoking according to XRCC1 codon 399 genotype in white women. ORs for occupational exposure to ionizing radiation were stronger for African-American and white women with codon 399 Arg/Arg genotype. High-dose radiation to the chest was more strongly associated with breast cancer among white women with XRCC1 codon 399 Arg/Arg genotype. Our results suggest that XRRC1 codon 399 genotype may influence breast cancer risk, perhaps by modifying the effects of environmental exposures. However, interpretation of our results is limited by incomplete knowledge regarding the biological function of XRCC1 alleles.
Seroprevalence and Risk Factors of Helicobacter Pylori Infection Among Children in South-East Nigeria Gastroenterology and Hepatology Research

subjects was 36.3%. Statistically significant association was found between age of the subjects, parental education, social class, ingestion of uncooked/ raw food materials and H. pylori infection ( p < 0.05). On logistic regression analysis, predictors of H. pylori infection were age 6-12 years (AOR = 2.42, 95% CI = 1.31-4.47, p = 0.005) and ingestion of uncooked/raw food materials (AOR= 2.38, 95% CI 1.14-8.33, p = 0.022). CONCLUSION : Risk factors associated with H. pylori infection include age, parental education, social class and ingestion of uncooked or raw food materials. ABSTRACT BACKGROUND: Helicobacter pylori is a common cause of infection among humans. The organism is usually acquired in childhood but may persist into adulthood resulting in chronic gastritis, peptic ulcer disease and adenocarcinoma. AIM : To determine the seroprevalence and risk factors of H. pylori infection among children seen at the Paediatric Out-Patient Clinic of a tertiary teaching hospital in South- East, Nigeria. METHODS: It was a cross-sectional study carried out among 248 children aged between 1 and 18 years seen at the Paediatric Outpatient Clinic at the tertiary hospital from August 2017 to October 2017. Information on socio-demographics, feeding practices, daycare attendance and vaccination were obtained and entered into a proforma. The serum obtained from the patient was tested for H. pylori antibodies. RESULTS: The seroprevalence of H. pylori infection among the
The Influence of School Culture, Principal Instructional Leadership, and Work Motivation on the Performance of SDN Teachers in Banjarbaru Utara District

This study aims to analyze the influence of school culture on teacher performance; principal instructional leadership with teacher performance; work motivation with teacher performance; school culture with work motivation; principal instructional leadership with work motivation; school culture with teacher performance through work motivation; instructional leadership of school principals with teacher performance through work motivation. The research sample was 152 teachers in 17 public elementary schools from a population of 265 teachers. The data was collected using instruments that had been tested for validity and reliability. The research data were analyzed descriptively and path analysis. The findings show that school culture influences teacher performance. the principal's instructional leadership influences teacher performance; work motivation influences teacher performance; school culture influences work motivation; the instructional leadership of the principal influences works motivation; Work motivation is an intermediary for the influence of school culture on teacher performance and the influence of the principal's instructional leadership on teacher performance.
Everolimus-Related Pneumonitis in Patients with Metastatic Breast Cancer: Incidence, Radiographic Patterns, and Relevance to Clinical Outcome

Background. This study investigated the incidence, radiographic patterns, and relevance to clinical outcome of everolimus-related pneumonitis (ERP) in patients with metastatic breast cancer (MBC). Materials and Methods. Data of patients with MBC treated with everolimus who had baseline and at least one follow-up chest computed tomography (CT) were obtained from a medical electronic database system. An independent review of the CT scans of these patients was conducted by two radiologists (NCT 03730428). Log-rank and Cox proportional hazard regression analyses were used for time-to-event analyses. Results. ERP was radiographically detected in 45 of 86 patients (52.3%). In more than 80% of these patients, ERP occurred during the first 4 months of everolimus treatment. Only 14 of the 45 patients with ERP were symptomatic (31.1%). Symptoms included cough, fever, and shortness of breath. Bilateral and lower distribution of the pneumonitis was most common. In most of the cases, ground-glass opacities and reticular opacities were noticed. Elderly patients were more likely to develop ERP. Patients with ERP had significantly longer progression-free survival (PFS; 6.8 vs. 4.1 months, p = .024) and overall survival (OS; 42.8 vs. 21.3 months, p = .016). ERP was a predictor of OS improvement confirmed by multivariate Cox analysis (hazard ratio, 0.49; 95% confidence interval, 0.25–0.97; p = .040). Conclusions. ERP was noted in half of the patients with MBC treated with everolimus. Our data suggested that ERP was associated with improved prognosis and may be used as a biomarker for the efficacy of everolimus inMBC. Close monitoring, prompt diagnosis, and proper treatment for ERP are essential to maintain the quality of life of patients and achieve maximum treatment benefits. The Oncologist 2021;26:e580–e587 Implications for Practice: Everolimus-related pneumonitis (ERP) is one of the most worrying drug adverse events, especially in Asian patients. However, little has been known about the clinical and radiographic details of ERP in patients with metastatic breast cancers (MBCs) treated with everolimus. The present study investigated the clinical characteristics, radiographic patterns, and its correlation with treatment outcome in patients with MBC. ERP was identified in more than half of patients with MBC during everolimus therapy and was associated with improved outcome. Close monitoring and prompt diagnosis and appropriate treatment for ERP are critical for the preservation of patients’ quality of life and achievement of maximal treatment benefits.
An Empirical Analysis of the Implicit Growth Rate for Industrial IPOs Listed in Pakistan

This study examines the cash flow growth rate implicit by offer prices of industrial IPOs using a reverse engineering DCF model. In addition, this study also investigates the bias of implicit growth relative to the realised growth rate by considering 19 IPOs listed on Karachi Stock Exchange during the period from 1995 to 2008. We find that the estimated growth in cash flows is slightly higher than realised growth rate, which indicates that the median IPO firm is overvalued by 61.5 percent at the offering. It is observed that estimation errors increase as a result of higher underpricing and diversified ownership. In addition, post-IPO returns are smaller for issues whose implicit growth rates are biased upward. We also find that IPOs underperform in long-run employing a buy-and-hold investment strategy. The policy implication of the study is to evolve a price discovery mechanism by the Securities and Exchange Commission of Pakistan which may help to reduce the overvaluation of IPOs upto some extent.
A42/A40 Ratios of Presenilin 1 Mutations Correlate with Clinical Onset of Alzheimer's Disease

Missense mutations in presenilin 1 cause early onset familial Alzheimer’s disease in a way that is not understood. I ncreased Aβ 42 /Aβ 40 ratios are the most consistent biochemical phenotype of such mutations in cultured cells and in vivo , and are thus considered central to the amyloid hypothesis. Previously, an inverse relation has been observed between the Aβ 42 /Aβ 40 ratio of such mutants and the clinical age of symptom onset in patients carrying the mutation. However, a recent extensive study by Sun et al. of assayed presenilin 1 mutants concluded that such a relationship is not evident. To reconcile the disagreement, three different clinical datasets were compared directly with the data by Sun et al. After considering data noise and measurement uncertainty, we find a clear and highly significant inverse correlation between the Aβ 42 /Aβ 40 ratio and the clinical age of onset in all three datasets even without removing noisy single- and double-patient data. With these data removed, the correlation coefficients increase further. The probability that these relationships are coincidental are approximately 0.1%.
New Trends and Issues Proceedings on Humanities and Social Sciences Identification of students’ learning motivation

The purpose of this study is to identify the overall learning motivation of primary and middle school students. In this research study, the effect of such variables as gender, parents’ educational status, academic achievement and grade level on primary and middle school students’ intrinsic and extrinsic motivation levels were investigated. This study has a descriptive model as it aims to reveal and explain the current situation in detail. The participants of this study were primary and middle school students from different schools in Isparta. The motivation level detection scale was administered to determine the overall learning motivation of the participants. Mann–Whitney U and Kruskal–Wallis T tests were used to compare the mean scores with respect to variables. The results imply that the intrinsic and extrinsic motivation levels of the primary school students who participated in this study did not differ in their gender, academic achievement and their parents’ educational status.
The Comparison of Left Ventricular Myocardial Performance Index (Tei index) in Term and Premature Neonatal Calves

e-ISSN:1308-0679 Abstract The neonatal heart is different from the adult heart in regard to both biochemical and structural features. Echocardiographic studies in human neonatology show that the myocardial function of left ventricle (LV) of premature infants differs from term infants. No study involving myocardial performance index (MPI) in neonatal animals has been performed until now. The objective of the present study was to evaluate LV MPI in premature calves and compare it to healthy newborn term calves. Ten healthy term and 20 premature calves were used. Echocardiographic evaluations were performed at days 1, 2, and 3 after birth and isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT), ejection time (ET), and MPI calculated with PW tissue Doppler imaging (PW-TDI). Results of the study showed that the IVRT of the LV of premature calves was shorter than seen in healthy term calves. The LVMPI of healthy term calves was also higher than in premature calves. In conclusion, MPI measurement is feasible in neonatal calves. Significant decrements in MPI and shorter IVRT of preterm calves could be the result of the non-closure of the ductus arteriosus (DA), and along with the decreased Doppler for exploring and follow up the cardiovascular system in neonatal Sağlıklı gününde doğmuş buzağıların LVMPI değeri prematüre buzağılara göre daha yüksekti. Sonuç olarak, MPI ölçümü neonatal buzağılarda uygulanabilir bir yöntemdir. Prematüre buzağıların MPI'sindeki önemli düşüşler ve daha kısa IVRT, duktus arteriyozusun (DA) kapanmamasının ve azalmış afterload'un bir sonucu olarak ortaya çıkabil mektedir. Ekokardiyografi ve Doppler görüntüleme tekniği, neonatal buzağılarda kardiyovasküler sistemi incelemek ve izlemek için yararlı araçlar olduğu ortaya
INSTITUTO POLITÉCNICO DE BEJA Escola Superior Agrária Curso de Mestrado em Engenharia Alimentar Development of a microencapsulated prototype to deliver low- molecular weight proteins at the onset of exogenous feeding of marine fish larvae

III Resumo . V Table of contents . VII List of Figures . IX List of Tables . X Chapter 1: General Introduction . 1 1.1. Aquaculture overview . 3 1.2. Ontogeny, physiology and nutrition of marine fish larvae . 4 1.3. Technological processes for production of fish larval microdiets . 6 1.4. Objectives . 8 Chapter 2: Technological developments: encapsulation of low-molecular weight proteins . 9 2.1. Material and methods . 11 2.1.1. Encapsulation of a fish protein hydrolysate by spray-drying technology . 11 2.1.2. Determining protein leaching in microencapsulated prototype particles . 11 2.1.3. Inclusion of microencapsulated particles in microdiets for first-feeding fish larvae. 12 2.1.4. Quality control in complete microdiets for fish larvae . 12 2.1. 5. Determining protein leaching in complete microdiets for fish larvae . 12 2.1. 6. Data analysis . 13 2.2. Results. 13 2.2.1. Protein leaching in microencapsulated particles . 13 2.2.2. Complete microdiets for fish larvae . 14 2.2.3. Quality control in complete microdiets for fish larvae . 17 2.3. Discussion . 17 Chapter 3: Biological testing of newly developed microencapsulated prototype: gilthead seabream larvae . 21 3.1. Material and methods . 23
CHANGES IN NUCLEAR CHROMATIN OF CULTURED ENDOTHELIAL AND SMOOTH MUSCLE CELLS* RANDAL S. BLANK AND THEODORE M. HOLLIS

Histamine, acting via membrane receptors, modulates a number of potentially important processes within the vascular wall. Histamine receptor activation affects cellular activities such as contractility, movement, growth, and metabolism. The present study entails a characterization of endothelial (EC) and smooth muscle cell (SMC) histamine receptors with respect to cytochemical indices of DNA content and chromatin dispersion. Both EC and SMC exhibited functionally active Hi and H2 receptors. Activation of either receptor type resulted in a substantial ploidy shift in EC but not in SMC cultures. The physico-chemical state of chromatin as assessed by Feulgen reactivity was altered in both cell types. H2 receptor activation elevated Feulgen reactivity in 20 nuclei, while in 40 nuclei both Hl and H2 receptors were active in this regard. Elevation of Feulgen reactivity of EC and SMC nuclear chromatin in response to histamine receptor agonists presumably represents a "chromatin activation reaction" reflecting alterations in the conformation of the deoxyribonucleoprotein (DNP) complex and accompanying changes in template activity. Disparity between agonist effects on 2C and 40 populations may reflect the cell cycle regulation of histamine receptors.
Kolorektal Poliplerin Klinikopatolojik Özellikleri: Türkiye'nin Kuzey-Doğu Anadolu Bölgesinden Retrospektif Bir Çalışma Clinicopathologic Features Of Colorectal Polyps: A Retrospective Study From North-Eastern Anatolia Turkey

Objectives : The aim of this study is to examine the patient characteristics, locations, presentations and histopathological features of colon polyps. Material and methods: We analyzed 153 biopsy specimens of 123 patients who underwent colonoscopy with biopsy of colonic polyps during a two-year period from 2014 to 2016, in Ağrı State Hospital and Erzurum Regional Training and Research Hospital, retrospectively. Results: The mean age was 58.9±15.6 years (Range: 19-90 years). 78 (63.4%) patients were males and 45 (36.6%) patients were females. 25 (20.3%) patients had two or three (multiple) polyps. In 4 biopsy specimens (2.6%) were diagnosed with carcinoma arose from tubular adenomas. The most common type of polyp was the adenomatous polyp (n:123, 80.3%). The most common anatomical locations of polyps were the rectum in 45 (29.4%) cases and the sigmoid colon in 45 (29.4%) cases. The mean size of polyps was 4.1 mm (range: 1mm-20 mm). High-grade dysplasia was found in 20 of 123 (13.2%) adenomatous polyps. Mean diameters were significantly different in adenomatous polyps with high-grade dysplasia and low-grade dysplasia (p<0.05). Conclusion: Most of the polyps were identified in patients aged 50 years or older. More than 50% of the polyps were found in the rectosigmoid part of the colon. The majority of the polyps were adenomatous and high-grade dysplasia was detected in large diameter polyps.
Comparing stress of children with neurodevelopmental the of

Background: Although parental stress is higher for children with neurodevelopmental disorders (NDs), it is unclear how this stress compares to more common NDs. The current study compared stress in parents of children with Williams Syndrome (WS), Down Syndrome (DS), and Autism Spectrum Disorders (ASD). The impact of individual and contextual factors was also explored. Method: Parents of children with WS (n = 107), DS (n = 79), and ASD (n = 79) completed a background questionnaire, a parental stress questionnaire, and a satisfaction with life questionnaire. Results: Although all groups displayed similar levels of parental stress, the factors that influenced this stress differed between the groups. There were also differences for life satisfaction and relationships between parental stress and individual and contextual factors. Conclusions: Although parents of children with NDs are not at an increased risk for parental stress, the results suggest that interventions should be syndrome specific.
Validity and Appropriate Uses of the Revised Technology Uses and Perceptions Survey (TUPS)

Abstract The purpose of this article is to explore validity evidence and appropriate uses of the revised Technology Uses and Perceptions Survey (TUPS) designed to measure in-service teacher perspectives about technology integration in K–12 schools and classrooms. The revised TUPS measures 10 domains, including Access and Support; Preparation of Technology Use; Perceptions of Professional Development; Perceptions of Technology Use; Confidence and Comfort Using Technology; Technology Integration; Teacher Use of Technology; Student Use of Technology; Perceived Technology Skills; and Technology Usefulness. We first provide a review of the literature supporting the design of the revised TUPS. We collected data from N = 1,376 teachers from one medium-sized school district in the state of Florida and conducted a variety of psychometric analyses. We performed internal structure analysis, correlation analysis, and factor analysis with these data. The results demonstrate that data collected from the TUPS are best used as descriptive, granular information about reported behaviors and perceptions related to technology, rather than treated as a series of 10 scales. These findings have implications for the appropriate uses of the TUPS. (Keywords: technology integration, K-12 teachers, survey, validity, reliability)
Prospective study to compare outcome between primary repair versus stoma formation in cases of emergency laparotomies

choice of is diﬃcult in managing emergency surgeries so we reviewed the management regarding the decision of type of and morbidity. Material and method – a prospective study was conducted by including 120 patients underwent emergency laparotomy for various indications at department of surgery JLNMCH Bhagalpur Bihar from feb 2016 to jan2017. Half of the patient underwent for primary repair while other half underwent stoma formation. Patients were assessed for pertinent clinical information and individuals requiring either of the two surgeries were compared. Result –Non- traumatic perforation constituted 61% of indication for Primary repair and Stoma formation. An adverse set of preoperative and intraoperative parameters were found in patients who underwent Stoma formation compared to Primary repair group. Wound infection was the most common complication (30%) and (26%)in group A and group B respectively. Overall mortality was 8%. Morbidity, in either groups, is signiﬁcantly inﬂuenced by an advanced age, a low Hb, hypoalbuminemia, an advanced lag period (>72 hours) and poor hemodynamic stability at the time of operation. e mean duration of hospital stay following either PR or SF is 10±3 days. PR is a safe procedure in emergency surgeries as long as patient is stable preoperatively and peritoneal cavity is non- compromised. SF seems to be a better option in adverse patient conditions. Patient outcome is inﬂuenced by poor clinical parameters and patient demographic in either surgery.
Occurrence of LINE, gypsy - and copia -like retrotransposons in 1 the clonally-propagated sweetpotato ( Ipomoea batatas L.)

: Retrotransposons are a class of transposable elements that represent a major 16 fraction of the repetitive DNA of most eukaryotes. Their abundance stems from their 17 expansive replication strategies. We screened and isolated sequence fragments of long 18 terminal repeat (LTR), reverse transcriptase (RT) and Gypsy -like RT and envelop (ENV)-like 19 domains of LTR retrotransposons, and two partial sequences of non-LTR long interspersed 20 element (LINE) in the clonally-propagated allohexaploid sweetpotato ( Ipomoea batatas ) 21 genome. Using dot blot hybridisation, these elements were found to be present in the ~1597 22 Mb haploid sweetpotato genome with copy numbers ranging from ~50 to ~4100 as observed 23 in the partial LTR (IbLtr-1) and LINE (IbLi-1) sequences, respectively. The continuous 24 clonal propagation of sweetpotato may have contributed to such a multitude of copies of 25 some of these genomic elements. Interestingly, the isolated Gypsy -like ENV and RT 26 sequence fragments, IbGy-1 (~2100 copies) and IbGy-2 (~540 copies) respectively, were 27 found to be homologous to the Bagy-2 cDNA sequences of barley ( Hordeum valgare ). 28 Although the isolated partial sequences were found to be homologous to other 29 transcriptionally active elements, future studies are required to determine whether they 30 represent elements that are transcriptionally active under normal and/or stressful conditions.