Miracle-dz/UniFAR-FTUs huggingface dataset:
Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas

Purpose: We performed a NCI-sponsored, prospective study of neoadjuvant FOLFIRINOX followed by chemoradiation with carboplatin/paclitaxel followed by surgery in patients with locally advanced gastric or gastroesophageal cancer. Patients and Methods: The primary objective was to determine completion rate of neoadjuvant FOLFIRINOX × 8 followed by chemoradiation. Secondary endpoints were toxicity and pathologic complete response (pCR) rate. Exploratory analysis was performed of circulating tumor DNA (ctDNA) to treatment response. Results: From October 2017 to June 2018, 25 patients were enrolled. All patients started FOLFIRINOX, 92% completed all eight planned cycles, and 88% completed chemoradiation. Twenty (80%) patients underwent surgical resection, and 7 had a pCR (35% in resected cohort, 28% intention to treat). Tumor-specific mutations were identified in 21 (84%) patients, of whom 4 and 17 patients had undetectable and detectable ctDNA at baseline, respectively. Presence of detectable post-chemoradiation ctDNA (P = 0.004) and/or postoperative ctDNA (P = 0.045) were associated with disease recurrence. Conclusions: Here we show neoadjuvant FOLFIRINOX followed by chemoradiation for locally advanced gastroesophageal cancer is feasible and yields a high rate of pCR. ctDNA appears to be a promising predictor of postoperative recurrence. See related commentary by Catenacci, p. 6281
Effect of Use of Instructional Materials on Self-Help Skills of Children with Intellectual Disabilities in Abuja School for The Handicapped, Abuja, Nigeria

INTRODUCTION: One role of special education is to increase the functional independence of children receiving services. Practitioners have used systematic instruction to teach academic, social, self-help, recreation/leisure, and vocational skills to different categories of children. OBJECTIVES: The purpose of this study was to ascertain the nature of self-help skills of children with intellectual disabilities and to determine the efficacy of instructional materials employed to teach self-help skills to children with intellectual disabilities. METHODS: Using descriptive statistics to analyse the research questions. The researchers purposively and conveniently assigned eight (8) children as participants, diagnosed with intellectual disabilities and have identified deficits in either personal care and hygiene such as teeth brushing, dressing and cleaning of drooling, as identified by the teachers, with three sets of instruments: Ihenacho Cognitive Domain Measurement Profile (ICDMP) and Collection of Materials for Self-Help Skills (CMSKS) to collect data. RESULTS: The results revealed that there was significant improvement in the ability to use a toothbrush in brushing teeth of the children in the second group and improvement in the experimental group using a toothbrush, the ability to use a handkerchief to clean drooling and ability to use detergent to wash clothes of the children in the second group and improvement in the experimental group using detergent. CONCLUSION: The study recommended that teachers and caregivers of children with intellectual disabilities should help in the acquisition of hygiene protection skills and behaviour through training.
Study of the water-rock interactions of spring waters in the northern Apennines

Forty three spring waters have been investigated in the Apennine area of Reggio Emilia province (Parco Regionale del Gigante). On the basis of the Langeher-Ludwig diagram, the (Na+K-Cl) vs (Ca+Mg) plot and the Cl - content, the waters have been divided in five main groups. (A) Carbonate calcic waters, soft to very hard (33-307 mg dm -3 CaCO 3 ). with low to moderate salinity (TDS 42-331 mg dm -3 . conductivity 75-502 μS cm -1 ); (B) Hard to very hard (163-286 mgdm -3 ) carbonate calcic to sulphate calcic waters with moderate salinity (TDS 201-357 mg dm -3 , conductivity 289-478 μScm -1 ); (C) Very hard (351-1864 mg dm -3 ) sulphate calcic waters with high salinity (TDS 473-2547 mg dm\, conductivity 570-2190 μS cm -1 ); (D) Soft to very hard (10-278 mg dm -3 ) carbonate calcic to sodic waters, with moderate salinity (TDS 398-460 mg dm -3 , conductivity 576-702 μS cm -1 ); (E) Soft (10 mg dm -3 ) sulphide chlorine sodic water and hard (160 mg dm -3 ) sulphide carbonate chlorine-rich sodic water with moderate to high salinity (TDS 315 and 754 mg dm -3 , conductivity 549 and 1148 μS cm -1 , respectively). The chemical composition of the waters suggests that calcite is practically the only source of Ca and alkalinity for group A, whereas group D and E reflect ion exchange and calcite and minor silicate dissolution during a strong water-rock interaction at depth.
Yield and yield attributes of banana (Musa paradisiaca L.) cv. Grand Nain influence by foliar application of silicon

The present experiment was conducted at Regional Horticultural Research Station, ASPEE College of Horticulture and Forestry, Navsari Agricultural University, Navsari during 2017-18 and 2018-19. An experiment was laid out in a randomized block design, comprising of three levels of potassium silicate and silicic acid (1, 2 and 3 ml/l/plant) along with control. The treatments were replicated thrice. The effects of foliar applications at 2nd, 3rd and 4th months after planting of different levels of potassium silicate and silicic acid on yield and yield attributes of banana cv. Grand Nain were recorded. The results indicated that foliar application of potassium silicate @ 3ml/l/plant at 2nd, 3rd and 4th MAP recorded significantly the maximum length and girth of bunch, weight of bunch,number of hands per bunch, fingers per bunch, weight of 3rd hand, length of finger and finger weight from 3rd hand and fruit yield.
Effect of different moisture regimes and nutrient management on yield attributes, yield and economics of hybrid rice (Oryza sativa L.)

A field experiment was conducted during two consecutive years of 2017-18 and 2018-19 at Division of Agronomy, ANDUAT, Kumarganj, Ayodhya to study the different moisture regimes and nutrient management on yield attributes, yield and economics of hybrid rice. Result data revealed that 7 cm irrigation given at 1 day after disappearance of ponded water produced significantly more yield attributes viz . , length of panicles, number of grains per panicle, weight of grains per panicle and 1000 grain weight, yield viz . , grain and straw yield and harvest index and economics of hybrid rice. Highest Gross and net returns and benefit: cost ratio was recorded with conventional irrigation. Application of 100% RDF of NPK (150: 75 : 60 kg ha) through inorganic fertilizers recorded significantly higher length of panicle, number of grains per panicle, weight of grains per panicle and 1000-grain weight, grain and straw yield, harvest index, gross and net returns and benefit cost ratio of hybrid rice as compared to rest of the nutrient management.
The Use of Macerating Enzymes in Grape Juice Processing

Laboratory and commercial plant trials were conducted to evaluate the efficacy of five commercial enzyme preparations in grape juice processing. The laboratory juice yield and color extraction trials using Rubired grapes demonstrated that a macerating enzyme could increase total juice yield. Trials at two commercial plants compared a macerating enzyme to pectinases routinely used in the plants. The results also demonstrated increased total juice yield with the hard-to-press grape varieties, Ruby Seedless and Flame Seedless. At plant A, where the most intensive study took place, there was an average yield increase of 8.5%. At plant B a 4.9% yield increase was obtained.
Consumer Adoption of Mobile Financial Services (MFS) in Bangladesh: A Randomized Conjoint Experiment

Mobile Financial Services (MFS) has become the new frontier in many countries. Since 2013, MFS in Bangladesh has risen steeply. The study aims to examine the MFS adoption behavior through the lens of modified Technology Acceptance Model (TAM) utilizing Randomized Conjoint Experiment for establishing a causal relationship between the attributes and adoption behavior. This study is the first attempt to encompass the causal relationship while investigating adoption behavior. Data were collected through a structured survey questionnaire at two districts in Bangladesh, including 2400 responses from 240 respondents. It was found that distance and cost per transaction has a significant impact, while ease of use has a moderately significant influence on customer's adoption behavior. However, the findings also concluded that social influence and trust have no significant influence. To both regulators and service providers, the findings will provide insights into the customer's point of view and industry demand as well. The study also included some suggestions for future investigations.
Anlotinib Inhibits the Growth of Breast Cancer Cells by Promoting Autophagy and Apoptosis via the Akt/GSK-3α Signalling Pathway

Background: Anlotinib, a multi-target tyrosine kinase inhibitor, has already been indicated to have significant anticancer effects on lung cancer, colon cancer and ovarian cancer in a phase II clinical trial, but its effect on breast cancer (BC) has not been adequately investigated. Methods: The proliferation activity of BC cell lines MCF-7 and MDA-MB-231 with the treatment of anlotinib was tested by Cell Counting Kit-8 (CCK-8) assay and immunocytochemistry (ICC) staining. We investigated the alteration of cell cycle and apoptosis and autophagy level and the underlying mechanism in the cell lines by quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR), Western blots, ICC and TUNEL staining and flow cytometry. Further, AT-3 cells were subcutaneously injected into C57BL/6 mice, followed by anlotinib intragastrically. The extracted tumours were assessed by qRT-PCR, Western blots and immunohistochemistry.Results: We found that anlotinib suppressed the cell viability and proliferation of MCF-7 and MDA-MB-231 cell lines and tumour growth in BC xenografts in mice, likely due to abnormal cell cycle arrest and induction of autophagy and apoptosis. Then, we further examined the underlying mechanism of anlotinib, and the results indicated that anlotinib induced apoptosis by promoting autophagy in MCF-7 and MDA-MB-231 cells by regulating the Akt/GSK-3α pathway. The analysis of data from patients with BC collected in TCGA revealed that increased VEGFA expression was related to BC.Conclusions: Our study demonstrated that anlotinib inhibited the growth of BC cells via promoting apoptosis through autophagy mediated by Akt/GSK-3α signalling and may be an effective new drug for BC treatment.
Factors associated with medication non-adherence among patients on hemodialysis: A cross-sectional study

Objectives: In this study, we aimed to evaluate the factors associated with medication non-adherence in terms of motivation and knowledge levels among hemodialysis-dependent patients. Patients and methods: Between March 2018 and April 2018, 134 Caucasian patients (78 males, 56 females; mean age 64.1±13.0 years; range, 23 to 86 years) on hemodialysis at two dialysis centers were included in this cross-sectional study. The Modified Morisky Scale was administered to assess the patients’ levels of motivation and knowledge about their medications. Results: The mean time on hemodialysis was 52.3±50.8 months and the mean number of prescribed medications was 7.5±3.5. The ratio of patients with a low level of motivation and knowledge were 17.2% and 11.9%, respectively. Hypertension was found to be an independent risk factor for low level of motivation (adjusted odds ratio [aOR]: 5.260 [95% confidence interval [CI]: 1.122-24.665], p=0.035). Being employed was found to be an independent risk factor for low level of knowledge (aOR: 5.000 [95% CI: 0.404-6.219], p=0.01). Conclusion: Hypertension and being employed were found to be associated factors of non-adherence to medication therapy. Healthcare professionals should recognize the factors associated with non-adherence and perform effective interventions to prevent adverse outcomes of non-adherence among patients receiving hemodialysis.
Mixed logit approach to modeling the severity of pedestrian-injury in pedestrian-vehicle crashes in North Carolina: Accounting for unobserved heterogeneity

Abstract In transportation, pedestrians are among the most vulnerable entities. Each year, a total of about 2,000 pedestrians are reported to be involved in traffic crashes with vehicles in North Carolina. Research efforts are needed to identify influencing factors and develop safety improvement measures for pedestrians. This study applies mixed logit (ML) model approach to exploring the potential unobserved heterogeneities across individual injury observations. Factors that significantly contribute to pedestrian injury severities resulting from pedestrian-vehicle crashes are examined under a variety of categories, including motorist, pedestrian, environmental, and roadway (etc.) characteristics. Police reported pedestrian-vehicle crash data collected from 2007 to 2014 in North Carolina are utilized. Parameter estimates and associated elasticities are used to interpret the results.
Estimation of Blood Glucose Concentration During Endurance Sports

In this paper, we describe a new statistical approach to estimate blood glucose concentration along time during endurance sports based on measurements of glucose concentration in subcutaneous interstitial tissue. The final goal is the monitoring of glucose concentration in blood to maximize performance in endurance sports. Blood glucose concentration control during and after aerobic physical activity could also be useful to reduce the risk of hypoglycemia in type 1 diabetes mellitus subjects. By means of a low invasive technology known as "continuous glucose monitoring", glucose concentration in subcutaneous interstitial tissue can now be measured every five minutes. However, it can be expressed as function of blood glucose concentration along time by means of a convolution integral equation. In the training phase of the proposed approach, based on measurements of glucose concentration in both artery and subcutaneous interstitial tissue during physical activity, the parameters of the convolution kernel are estimated. Then, given a new subject performing aerobic physical activity, a deconvolution problem is solved to estimate glucose concentration in blood from continuous glucose monitoring measurements
Introduced Canadian Eastern grey squirrels: squirrelpox virus surveillance and why nothing matters

Squirrelpox virus (SQPV), an unapparent infection of the Eastern grey squirrel ( Sciurus carolinensis ), is considered to be mediating the ecological replacement of the Eurasian red squirrel ( Sciurus vulgaris ) in the United Kingdom (UK) and Ireland. Evidence suggests that the Eastern grey squirrel is the natural reservoir host of SQPV and therefore there is considerable concern amongst conservationists that when translocated out of its natural range in North America, the Eastern grey squirrel could pose a similar threat to encountered indigenous squirrel populations. Serum samples collected from Eastern grey squirrels from British Columbia (BC), Canada, an introduced population derivedfromsquirrelstranslocatedatthebeginningofthe20thCentury, weresurveyedforevidence of antibodies against SQPV. None of the 130 samples tested had antibodies to the virus, contrasting with15outof19(79%)positiveserumsamplescollectedfromOntario, apopulationwithinthenat-ural range of the Eastern grey squirrel. We conclude that BC is currently free of SQPV and that to maintain the virus-free status further translocations of grey squirrels from their native range should be prevented. A comprehensive study of the founding population and comparison with the other populations in BC, including broad epidemiological surveillance for the virus is recommended as an early warning for potential incursions of the virus and the threats that this may pose.
Design of a Planar Inverted F-Antenna for Medical Implant Communications Services Band

A planar inverted F-implantable antenna is designed using the medical implant communications service (MICS) band (402–405MHz). The proposed antenna is designed using microstrip lines and short-circuited pin connecting between the ground plane and the patch. The total size of the proposed antenna is (24×32×2 mm3). The patch dimensions are (16×24 mm2). The calculated bandwidth at a return loss of -10 dB is 1MHz. The S-parameters, the near and far-fields, and the specific absorption rate (SAR) of the antenna is simulated and characterized. The design is carried out using CST Studio.
Ozonized solutions favor the repair of experimentally induced skin wounds in rats

ABSTRACT: This study aimed to evaluate and compare the effects of ozonized solutions on tissue wound repair in rats. Treatments consisted of ozonized water (GA), 0.9% sodium chloride (GCL), ozonized oil (GO), and 0.2% allantoin cream (GAL). The morphometric evaluation showed that wounds of the GA group presented a higher degree of retraction (p<0.05) at three and eight days of treatment (37.96 and 84.81%, respectively). Picrosirius red staining showed that groups GA and GO presented higher deposition (p<0.05) of type I collagen at 15 and 22 days of treatment, respectively. The neovascularization was higher in wounds of group GO on days 3, 8, and 15 (p<0.05), with higher VEGF immunostaining. (p<0.05). Thus, ozonized water enhances wound retraction and assists in the maturation and remodeling phase, while ozonized oil promotes higher neovascularization during tissue repair and higher deposition of type I collagen from the third week of treatment.
Product development, nutrient analysis and sensory evaluation of maize chips, enhanced with moringa oliefera

Product development of nutritionally enhanced foods, to improve food and nutrition security in developing countries, has gained momentum over the years. This study involved the product development optimization, analysis of nutrient and physiochemical content of a maize chip, enhanced with moringa oliefera, as a nutritious and safe snack for children. Food product development trials, nutritional analysis and microbiological testing were conducted. Two samples of moringa maize chip were developed: sample 1 (1 g moringa / 22 g portion of maize chips) and sample 2 (2g moringa / 22g portion of maize chips). Samples 1 and 2 contained 1.81g and 2.27g of fat, 84.9 μg and 100.2 μg of vitamin A and 220 mg and 273 mg of calcium, respectively. Sensory evaluation of the product developed was conducted through a cross-sectional study. One hundred children, aged 9–13 years from four schools were recruited through stratified random sampling from Verulam, Durban, South Africa. Using a validated five-point facial hedonic scale, sensory evaluation revealed that the chips, containing 2 g moringa, were preferred to those with 1 g moringa, for taste and texture. The promising nutritional analysis results and sensory evaluation outcomes indicated the potential for maize chips containing moringa, to serve as a healthier, sensory acceptable snack suitable for children.
A novel telerehabilitation with educational program for caregivers using telelecture is a feasible procedure for fall prevention in elderly people – A pilot study

Background: The importance of fall prevention rehabilitations has been well recognized. Recently, telerehabilitation was developed, however, there have been no reports on the use of telerehabilitation with direct support from specialists for fall prevention among the elderly. We herein reported telerehabilitation by carers educated by our novel educational program.Methods: Nine elderly people in two nursing homes were enrolled using our original criteria. Carers are educated with our educational program using telelecture system. Telerehabilitation was performed by carers following the instruction from rehabilitation specialists in Asahikawa Medical University using the telemedicine system every 2-4 weeks for three months. Carers were assessed with our original questionnaire before and after the telelecture. Berg Balance Scale (BBS), Timed Up & Go test (TUG test), Hand-held dynamometer (HHD) and Mini-Mental State Examination (MMSE) were assessed before and after telerehabilitation.Results: The average number of times to perform telerehabilitation in all institutes was 4.7. Levels of understanding of carers were significantly increased after the telelecture. No adverse event occurred during the study period. Median BBSs before and three months after telerehabilitation were 43 and 49, respectively. Those of TUG test, right and left HHD and MMSE were 17.89 and 18.53, 7.95 and 11.55, 9.85 and 13.20, and 16 and 19, respectively. All results were improved after telerehabilitation.Conclusions: Our telerehabilitation program exhibited significant effects in elderly people as well as levels of understanding rehabilitation of caregivers in the facilities for the elderly people safely.Trial registration: University Hospital Medical Information Network Clinical Trials Registry（UMIN-CTR）UMIN000041439, August 17th, 2020
The Early Start of Gonadotropin-releasing Hormone Antagonist Versus Flexible Antagonist Ovarian Stimulation Protocol in Poor Responders: A Randomized Clinical Trial

Background: Determining the initiation day of antagonist administration is an important and challenging issue and different results have been reported in the previous studies. The present study was designed to compare the controlled ovarian hyperstimulation (COH) cycles outcomes of the early start of gonadotropin-releasing hormone antagonist (GnRH-ant) protocol with conventional flexible GnRH-ant protocol in patients with poor ovarian response (POR) diagnosis. Methods: This randomized controlled trial was performed on infertile women who were diagnosed as poor ovarian responder in IVF/ICSI cycles at Arash Women’s Hospital affiliated to Tehran University of Medical Sciences between September 2019 and May 2020. POR was defined according to the Bologna criteria and the eligible women were randomly allocated into an experimental (early onset GnRH-ant) and control (flexible GnRH-ant) groups. The women in the experimental group received recombinant gonadotropins (150-225 IU) and GnRH-ant (0.25 mg) simultaneously on the second day of the cycle. In control group, the starting and dose of gonadotropins were similar but daily administration of GnRH-ant was initiated when the leading follicle diameter was ≥ 13 mm. The IVF/ICSI outcomes were compared between groups.Results: Totally, 116 women were randomly assigned to early start antagonist group (n=58) and control group (n=58). The analysis showed that the two groups did not have a statistically significant difference in terms of the ovarian stimulation duration and the total dose of used gonadotropins. Although, the total number of MII oocytes in early start of antagonist group was significantly higher than that of in control group (P=0.04). In the following, clinical and ongoing pregnancy rates per ET in early start of antagonist group were significantly higher than those of in control group (P=0.02 and P=0.03, respectively); however, the implantation and miscarriage rates were similar between group.Conclusion: The early onset of GnRH-ant protocol can improve the number of retrieved and MII oocytes rates and probably the pregnancy outcome after fresh embryo transfer in POR patients; however, larger randomized clinical trials are required to compare the pregnancy outcomes after this approach with other COH protocols with considering cost-effectiveness issue.Trial registration: IRCT, IRCT20110731007165N9. Registered 8 February 2020 – Registered while recruiting, https://www.irct. ir/trial/45024.