Miracle-dz/UniFAR-FTUs huggingface dataset:
Pradabwong, Jiraporn and Braziotis, Christos and Tannock, James D.T. and Pawar, Kulwant S. (2017) Business process management and supply chain collaboration: effects on performance

Purpose This study examines the interrelationships among Business Process Management (BPM), Supply Chain Collaboration (SCC), collaborative advantage and organisational performance. Design/methodology/approach Data was collected from 204 manufacturing firms in Thailand, and the interrelationships proposed in the framework were tested via Structural Equation Modelling. Findings Our study highlights the role of intraand inter-organisational practices, and clearly demonstrates the joint role and impact of BPM and SCC respectively. The results provide empirical evidence that BPM improves both organisational performance and collaborative activities. Also, SCC and collaborative advantage can have indirect positive impacts on organisational performance. Research limitations/implications This work could be expanded by adopting a supplementary dyadic or extended supply chain approach, and could also consider contextual factors, which were outside of the scope of our study. Practical implications The BPM approach has a positive impact on organisational performance, which is essential for collaborative activities between a firm and its supply chain partners. Further, effective BPM and SCC practices lead to enhanced performance and collaborative benefits. Practitioners should be better able to define and measure specific actions relating to their BPM and SCC practices. Originality/value This paper stresses the need to consider the interrelationships between BPM, SCC, collaborative advantage and organisational performance for both direct and indirect effects. Rather than focusing only on improvement at the individual firm level, SCC is vital to compete in the market. Improving the effectiveness of SC allows higher organisational performance levels than those that could be achieved in isolation.
interventions for parents of young children to A review

Background: Dental caries is the most prevalent preventable condition in children. A key preventive home-based oral health behaviour is the adoption and maintenance of parental supervised toothbrushing until 8 years of age. Aim: To examine interventions promoting parental supervised toothbrushing practices to reduce dental caries in young children (<8 years old). Design: Interventions promoting parental involvement in home-based toothbrushing in children under 8 years old and their impact on caries were subjected to review. Electronic databases (MEDLINE, EMBASE, PubMed, Web of Science, PsycINFO, Scopus, and the Cochrane Library), references, and unpublished literature databases were searched for relevant literature. Results: Of the 10 176 articles retrieved, forty-two articles were included. The Theoretical Domains Framework was used to code intervention content, with the main domains addressed being knowledge (41/42), skills (35/42), and environmental context and resources (22/42). Sufficient descriptions of the intervention development, delivery, and evaluation were lacking, with only 18 studies being underpinned by theory. Twenty-nine studies explored the impact on caries yielding mixed results. Conclusions: There are few interventions targeting home-based oral health behaviours underpinned by theory and methodological rigour in their development and evaluation. This demonstrates a clear need for future interventions to be guided by complex intervention methodology.
NDT_A_247957 1341..1352

1The Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia; 2Department of Aged Care, Prince of Wales Hospital, Sydney, NSW, Australia Abstract: Delirium occurring in a patient with preexisting dementia is referred to as delirium superimposed on dementia (DSD). DSD commonly occurs in older hospitalized patients and is associated with worse outcomes, including higher rates of mortality and institutionalization, compared to inpatients with delirium or dementia alone. This narrative review summarizes the screening, diagnosis, management, and pathophysiology of DSD and concludes by highlighting opportunities for future research. Studies were identified via Medline and PsycINFO keyword search, and handsearching reference lists. Conceptually, DSD could be considered an “acute exacerbation” of dementia precipitated by a noxious insult akin to an acute exacerbation of heart failure or acute on chronic renal failure. However, unlike other organ systems, there are no established biomarkers for delirium, so DSD is diagnosed and monitored clinically. Because cognitive dysfunction is common to both delirium and dementia, the diagnosis of DSD can be challenging. Inattention, altered levels of arousal, and motor dysfunction may help distinguish DSD from dementia alone. An informant history suggestive of an acute change in cognition or alertness should be investigated and managed as delirium until proven otherwise. The key management principles include prevention, identifying and treating the underlying precipitant(s), implementing multicomponent interventions to create an ideal environment for brain recovery, preventing complications, managing distress, and monitoring for resolution. Informing and involving family members or caregivers throughout the patient journey are essential because there is significant prognostic uncertainty, including the risk of persistent cognitive and functional decline following DSD and relapse. Furthermore, informal carers can provide significant assistance in management. Emerging evidence demonstrates that increased exposure to delirium is associated with neuronal injury and worse cognitive outcomes although the mechanisms through which this occurs remain unclear. Given the clinical overlap between delirium and dementia, studying shared pathophysiological pathways may uncover diagnostic tests and is an essential step in therapeutic innovation.
Master’s degree Project in Innovation and Industrial Management A Race to the Top in the Era of Artificial Intelligence A Qualitative Study examining challenges & opportunities for small and medium sized Swedish companies in AI adoption

Background & Purpose: This study focuses on challenges to AI adoption in smalland medium sized enterprises (SMEs) in Sweden, as well as solutions to these challenges. The background, and the reason for studying the topic, lies in Sweden’s stated vision of becoming one of the world leaders in adopting the powers of Artificial Intelligence (AI). Despite this vision, the research regarding AI adoption in Swedish companies, especially in Swedish SMEs, is very sparse. The purpose of this study is to identify challenges experienced by Swedish SMEs in adopting AI and, by interviewing companies and individuals with experience in AI implementation, identifying recommendations on how to solve or mitigate these challenges. These recommendations are, in the last stages of the thesis, adapted to fit to the context of the Swedish SMEs, i.e. to the Swedish business culture and to companies with fairly limited resources. Methodology: This is a qualitative study in which 10 interviews are held. Three interviews are held with Swedish AI aspirants, i.e. Swedish SMEs that have a wish to implement AI. The remaining six interviews are held with Swedish and American companies and individuals that have knowledge and experience of working with AI. These interviewees are referred to as experts. The interview findings are analyzed by a thematic analysis based on categories and themes found in the literature and, in some cases, that emerged during the interviews. The thematic analysis results in seven challenges and seven recommendations regarding AI adoption. Findings & Conclusions: Seven challenges and seven recommendations are found. The challenges include immaturity of the AI-technology, compatibility with the company, evaluating, developing and implementing the technology, lack of resources, lack of knowledge, establishing a culture of innovation and the effects that the external environment has. The recommendations include learning about fields related to AI, using external forces, embracing being a smaller company, promoting change, motivating and inspiring with soft factors, developing a culture of innovation and understanding the specific company context. Simply put, Swedish SMEs need to thoroughly assess their current capabilities and start learning about fields related to AI as a first step. Once this is done, they need to evaluate whether to use external forces (such as off-she-shelf AI solutions and/or consultants) and, if so, to which extent. They should also take advantage of being a smaller company in the sense that their AI-solutions can be much simpler than for larger companies. Lastly, they should learn about what country specific factors that might make the implementation of AI easier or more difficult. Such factors include Swedes being innovation friendly, the existence of free learning opportunities and the in Sweden common flat organizational structure.
Cyclins D2 and D1 Are Essential for Postnatal Pancreatic (cid:2) -Cell Growth

Regulation of adult (cid:1) -cell mass in pancreatic islets is essential to preserve sufﬁcient insulin secretion in order to appropriately regulate glucose homeostasis. In many tissues mitogens inﬂuence development by stimulating D-type cyclins (D1, D2, or D3) and activating cyclin-dependent kinases (CDK4 or CDK6), which results in progression through the G 1 phase of the cell cycle. Here we show that cyclins D2 and D1 are essential for normal postnatal islet growth. In adult murine islets basal cyclin D2 mRNA expression was easily detected, while cyclin D1 was expressed at lower levels and cyclin D3 was nearly undetectable. Prenatal islet development occurred normally in cyclin D2 (cid:2) / (cid:2) or cyclin D1 (cid:3) / (cid:2) D2 (cid:2) / (cid:2)
CLINICAL AND ECHOCARDIOGRAPHIC SURVEY OF THE EHLERS(cid:1)DANLOS SYNDROME

Cardiac abnormalities such as mitral valve prolapse "MVP# are reported to be common features of the Ehlers(cid:1)Danlos syndrome "EDS#\ and it has been suggested that the majority of patients with type IV EDS will have cardiac involvement and vascular aneurysms[ However\ the evidence for valve lesions is inconsistent and often based on early clinical studies using mainly M! mode echo[ We studied 22 patients "six male\ 16 female^ median age 24 yr# with EDS "29 type I\ II or III\ three type IV# and 29 age! and sex! matched controls[ The study assessed skin stretch and joint hypermobility using Beighton and Contompasis scores[ Echocardiographic examination included standard two! dimensional views from the parasternal and apical windows\ and measurement of the aorta at four sites "annulus\ sinotubular junction\ arch and abdominal aorta#[ Echocardiographic abnormalities were found in four patients "01[0)# "one atrial septal aneurysm\ one tricuspid prolapse\ two MVP# and two controls "5[6)#[ MVP was found in 5[0) of EDS patients and 6) of controls[ Seven patients had previously been diagnosed as having MVP^ only two were shown to have true MVP using current criteria[ None of those with type IV EDS had any echocardiographic abnormality[ No patients with EDS had mean aortic dimensions outside the normal range at any of the points tested[ Cardiac symptoms were more frequent amongst the patients than controls "atypical chest pain 37)\ P (cid:30)9[9990^ palpitation 28)\ P (cid:30)9[990^ exertional dyspnoea 29)#[ A wide range of rheumatological complaints were reported "current arthralgia 64)^ recent back pain 61)\ P (cid:30)9[994^ recurrent dislocation 61)#[ Contrary to earlier published observations\ we have not found an increased incidence of cardiac abnormalities in EDS[ This syndrome may be relatively more benign\ from the cardiac point of view\ than was previously thought[ K EY Ehlers(cid:1)Danlos
ANAESTHETIC TECHNIQUES IN DAY CASE UROLOGICAL SURGERIES IN BENUE

Background: The global economic constraints and increasing financial awareness has led to an increase in day case surgeries because there is reduction in healthcare cost. Day case surgery also gives rise to reduction of psychological and emotional impact, reduced behavioural problems, less disruption to family life as well as opening up more bed spaces for those who may actually require them. Urological procedures are infra umbilical procedures. Anaesthesia for these procedures entails less disturbance o the respiratory system, and it is also possible to carry out most of these surgeries under regional and local anaesthesia. Methodology: A total of 52 case files of eligible patients were retrieved from the records department of Benue State University Teaching Hospital (BSUTH), Makurdi, Nigeria, after my application to the department was approved. Relevant information were extracted from the patients’ folders and transferred into a prepared proforma for analysis. Results: Patients aged 51 years and above constituted 86.6% of the study, with those aged between 61 and 70 being 17 making up the greatest number; 32.7% of the study population. All patients were male. The greatest indication for day case surgery surveyed in this study were benign prostatic hypertrophy to rule out cancer of the prostate and prostate cancer alone. Also in the study conducted, prostate biopsy was the most common procedure performed. Hypertension was the most common co-morbidity found among these patients. All but one of the procedures were performed with either regional anaesthesia or local infiltration. Caudal epidural block was the most commonly used anaesthetic technique. Conclusion: Urological procedures being infra-umbilical are quite amenable to either regional anaesthesia or local anaesthesia. This study has demonstrated that caudal epidural block is the anaesthetic technique of choice in day case urological surgery in this facility. Local anaesthesia is next most common technique while GA is hardly used. LA and regional techniques entail fewer disturbances to the respiratory system and these were the anaesthetic techniques mostly employed in this study.
Neutral carbon and CO in 76 (U)LIRGs and starburst galaxy centers A method to determine molecular gas properties in luminous galaxies

We present fluxes in both neutral carbon [CI] lines at the centers of 76 galaxies with FIR luminosities between 10^{9} and 10^{12} L(o) obtained with Herschel-SPIRE and with ground-based facilities, along with the J=7-6, J=4-3, J=2-1 12CO and J=2-1 13CO line fluxes. We investigate whether these lines can be used to characterize the molecular ISM of the parent galaxies in simple ways and how the molecular gas properties define the model results. In most starburst galaxies, the [CI]/13CO flux ratio is much higher than in Galactic star-forming regions, and it is correlated to the total FIR luminosity. The [CI](1-0)/CO(4-3), the [CI](2-1) (2-1)/CO(7-6), and the [CI] (2-1)/(1-0) flux ratios are also correlated, and trace the excitation of the molecular gas. In the most luminous infrared galaxies (LIRGs), the ISM is fully dominated by dense and moderately warm gas clouds that appear to have low [C]/[CO] and [13CO]/[12CO] abundances. In less luminous galaxies, emission from gas clouds at lower densities becomes progressively more important, and a multiple-phase analysis is required to determine consistent physical characteristics. Neither the CO nor the [CI] velocity-integrated line fluxes are good predictors of H2 column densities in individual galaxies, and X(CI) conversion factors are not superior to X(CO) factors. The methods and diagnostic diagrams outlined in this paper also provide a new and relatively straightforward means of deriving the physical characteristics of molecular gas in high-redshift galaxies up to z=5, which are otherwise hard to determine.
structural pharmacology to study complex diseases and personalized medicine.

: Genome-Wide Association Studies (GWAS), whole genome sequencing, and high-throughput omics techniques have generated vast amounts of genotypic and molecular phenotypic data. However, these data have not yet been fully explored to improve the effectiveness and efficiency of drug discovery, which continues along a one-drug-one-target-one-disease paradigm. As a partial consequence, both the cost to launch a new drug and the attrition rate are increasing. Systems pharmacology and pharmacogenomics are emerging to exploit the available data and potentially reverse this trend, but, as we argue here, more is needed. To understand the impact of genetic, epigenetic, and environmental factors on drug action, we must study the structural energetics and dynamics of molecular interactions in the context of the whole human genome and interactome. Such an approach requires an integrative modeling framework for drug action that leverages advances in data-driven statistical modeling and mechanism-based multiscale modeling and transforms heterogeneous data from GWAS, high-throughput sequencing, structural genomics, functional genomics, and chemical genomics into unified knowledge. This is not a small task, but, as reviewed here, progress is being made towards the final goal of personalized medicines for the treatment of complex diseases. chemical genomics, functional genomics, structural genomics, and structure-based drug discovery, together with efforts in systems pharmacology, developing personalized associated genes; drug–target interactions; protein conformational states; biological pathways; cellular networks, such as protein–protein interaction networks; molecular phenotypes, such as gene expression profiles; and different organism phenotypes. Using these individualized drug response phenotypes, the probability of causal mutations, involved targets, conformational states, molecular complexes or functional modules, and biological pathways and their links can be established by a priori knowledge from mechanism-based modeling or estimated using a Bayesian statistical framework.
A Central Role for Ets-2 in the Transcriptional Regulation and Cyclic Adenosine 5 (cid:1) -Monophosphate Responsiveness of the Human Chorionic Gonadotropin- (cid:1) Subunit Gene

Ets-2 has an important role in controlling the differentiation of the placenta. Here we show by truncation and mutational analysis that two closely spaced Ets-2 binding sites in the proximal promoter of the human chorionic gonadotropin (cid:1) 5 (hCG (cid:1) 5) gene constitute a major enhancer for hCG (cid:1) gene expression in JAr and JEG-3 human choriocarcinoma cells and in mouse NIH3T3 cells. Contrary to a previous report, we also demonstrate that the ability of Ets-2 to enhance transcription is subject to control by the Ras/MAPK pathway, al-though this relationship is less easily demonstrable in JAr and JEG-3 choriocarcinoma cells than in the 3T3 cells because the former already possess a fully activated MAPK pathway and contain Ets-2 phosphorylated at threonine residue at T72. Coexpression of Ets-2 and activated Ras in 3T3 cells led to activation of MAPK/ERK kinase 1/2, phosphorylation of Ets-2 at T72, and an approximately 120-fold up-regulation of reporter gene expression from a short ( (cid:2) 175) hCG (cid:1) promoter. Fold activation in JAr and JEG-3 cells was rather less (20- to 30-fold), but basal activity was much higher. These effects on promoter activity were largely reversed in presence of the MAPK inhibitor PD98059, which prevents ERK1/2 activation, and partially reversed by mutating T72 on Ets-2. We finally show that the ability of 8-bromoadenosine-cAMP to stimulate hCG (cid:1) promoter activity in JAr and JEG-3 cells oc-curs with a short promoter lacking the upstream elements previously considered to be essential for cAMP activation of the gene and, through mutational analysis, confirm that the major cAMP effects on the hCG (cid:1) promoter are mediated through the proximal Ets-2 enhancer. The data are consistent with the hypothesis that Ets-2 has a general and possibly essential role in controlling the activity of genes associated with trophectoderm differentiation. Endocrinology 17: 11–26,
PREVALENCE OF OBESITY AND AWARENESS OF BARIATRIC SURGERY AMONG THE GENERAL POPULATION IN TAIF CITY

: Background: According to previous studies conducted in Kingdom of Saudi Arabia (KSA), the prevalence of obesity was more than 35%. During the last few decades, the importance of bariatric surgery for weight reduction had continuously been increasing. Compared to non-surgical interventions, bariatric surgery was associated with greater improvement in reducing obesity as well as associated morbidity and mortality. Objective: The current study aimed to estimate the prevalence of overweight and obesity among the general population in Taif City in addition to assessing the level of awareness and knowledge about bariatric surgery among the same population. Settings and Design: This was a cross-sectional observational study conducted in Taif city, Saudi Arabia. Methods and Material: Data were collected using a designed questionnaire which was published online among the general population of Taif City. Data were collected during the period from February 2018 to March 2018. The questionnaire was consisted of 4 parts including the demographics data, anthropometric measurements, knowledge about obesity and its complications and knowledge about bariatric surgery and its complications. Results: A total of 664 participants took part in this study. The prevalence of overweight and obesity among the studies population were found to be 24% and 33.6% respectively with a mean± SD BMI of 28.3± 15.8 kg/m. This study revealed a good level of knowledge about obesity but low level of awareness about bariatric surgery among participants. Conclusions: Our results suggested that we still need more health education programs for the general population to raise the level of awareness about obesity and bariatric surgery and to minimize the prevalence of obesity and its complications among the general population in Taif City.