Miracle-dz/UniFAR-FTUs huggingface dataset:
Capitellum fractures: Treatment with headless screws and outcomes

Objectives This study aims to present the results of 21 patients with capitellum fractures treated with open reduction and headless screws by a single experienced surgeon. Patients and methods Twenty-one patients (13 males, 8 females; mean age 39 years; range, 18 to 63 years) who were admitted to our clinic between June 2011 and January 2018 with the diagnosis of capitellum fracture and followed-up for a mean period of 45 months (range, 12 to 90 months) were included in this retrospective study. The fractures were fixed with headless cannulated screws by a single surgeon. Results The mean range of motion was 102° (range, 65° to 140°) during flexion-extension and 165° (range, 130° to 180°) during supination-pronation. The mean preoperative visual analog scale (VAS) score was 8.5 (range, 6 to 10), whereas the mean postoperative VAS score was 2.2 (range, 0 to 6). According to the Mayo Elbow Performance score, nine patients were evaluated as excellent, six patients as good, four patients as fair, and two as poor. The mean Quick-Disabilities of the Arm, Shoulder and Hand score was 25.1 (range, 4 to 57). Avascular necrosis developed in three patients (14%) and heterotopic ossification was detected in one patient (4%). Conclusion Capitellum fractures are difficult to diagnose and treat, and good results can only be achieved by an accurate diagnosis, careful surgical technique, and stable fixation. Larger and more comprehensive studies are required to establish a generalization and more accurate inferences on this limitedly studied subject.
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats

Charcot–Marie–Tooth disease 1 A (CMT1A) is caused by an intrachromosomal duplication of the gene encoding for PMP22 leading to peripheral nerve dysmyelination, axonal loss, and progressive muscle weakness. No therapy is available. PXT3003 is a low‐dose combination of baclofen, naltrexone, and sorbitol which has been shown to improve disease symptoms in Pmp22 transgenic rats, a bona fide model of CMT1A disease. However, the superiority of PXT3003 over its single components or dual combinations have not been tested. Here, we show that in a dorsal root ganglion (DRG) co‐culture system derived from transgenic rats, PXT3003 induced myelination when compared to its single and dual components. Applying a clinically relevant (“translational”) study design in adult male CMT1A rats for 3 months, PXT3003, but not its dual components, resulted in improved performance in behavioral motor and sensory endpoints when compared to placebo. Unexpectedly, we observed only a marginally increased number of myelinated axons in nerves from PXT3003‐treated CMT1A rats. However, in electrophysiology, motor latencies correlated with increased grip strength indicating a possible effect of PXT3003 on neuromuscular junctions (NMJs) and muscle fiber pathology. Indeed, PXT3003‐treated CMT1A rats displayed an increased perimeter of individual NMJs and a larger number of functional NMJs. Moreover, muscles of PXT3003 CMT1A rats displayed less neurogenic atrophy and a shift toward fast contracting muscle fibers. We suggest that ameliorated motor function in PXT3003‐treated CMT1A rats result from restored NMJ function and muscle innervation, independent from myelination.
Time trends in pediatric fractures in a Swedish city from 1950 to 2016

Background and purpose — As previous studies indicate time trends in pediatric fracture incidence, we followed the incidence in a Swedish city between 1950 and 2016. Patients and methods — Malmö city, Sweden had 322,574 inhabitants in 2015. We used diagnosis registry, charts, and radiographs of the only city hospital to classify fractures in individuals < 16 years in 2014–2016, and compared these with data from 1950–2006. We used joinpoint regression to analyze time trends and present results as mean annual percentage changes (APC). Differences between periods are described as incident rate ratios (IRR). To describe uncertainty, 95% confidence intervals (CI) are used. Results — During 2014–2016 the pediatric fracture incidence was 1,786 per 105 person-years (boys 2,135 and girls 1,423). From 1950 onwards age-adjusted fracture incidence increased until 1979 in both boys (APC +1.5%, CI 1.2–1.8) and girls (APC +1.6%, CI 0.8–2.5). The incidence remained stable from 1979 to 2016 (APC in boys 0.0%, CI –0.3 to 0.3 and in girls –0.2%, CI –1.1 to 0.7). Age-adjusted incidence 2014–2016 was higher than 2005–2006 in girls (IRR 1.1, CI 1.03–1.3), but not in boys (IRR 1.0, CI 0.9–1.1). Interpretation — Fracture incidence was in girls higher in 2014–2016 than in 2005–2006. However, only with more than 2 measuring points are meaningful trend analyses possible. When we analyzed the period 1950–2016 with 17 measuring points and joinpoint regression, we found that fracture incidence increased in both sexes until 1979 but has thereafter been stable.
A Low-Cost Computational Method for Characterizing Event-Related Potentials for BCI Applications and Beyond

Event-related potentials (ERPs) are important neurophysiological markers widely used in scientific, medical and engineering contexts. Proper ERP detection contributes to widening the scope of use and, in general, improving functionality. The morphology and latency of ERPs are variable among subject sessions, which complicates their detection. Although variability is an intrinsic feature of neuronal activity, it can be addressed with novel views on ERP detection techniques. In this paper, we propose an agile method for characterizing and thus detecting variable ERPs, which keeps track of their temporal and spatial information through the continuous measurement of the area under the curve in ERP components. We illustrate the usefulness of the proposed ERP characterization for electrode selection in brain-computer interfaces (BCIs) and compare the results with other standard methods. We assess ERP classification for BCI use with Bayesian linear discriminant analysis (BLDA) and cross-validation. We also evaluate performance with both the information transfer rate and BCI utility. The results of our validation tests show that this characterization helps to take advantage of the information on the evolution of positive and negative ERP components and, therefore, to efficiently select electrodes for optimized ERP detection. The proposed method improves the classification accuracy and bitrate of all sets of electrodes analyzed. Furthermore, the method is robust between different day sessions. Our work contributes to the efficient detection of ERPs, manages inter- and intrasubject variability, decreases the computational cost of classic detection methods and contributes to promoting low-cost personalized brain-computer interfaces.
Polyamine Titre in Relation to Chill-Sensitivity in Phaseolus sp.

Guye, M. G. , Vigh, L. and Wilson, J. M. 1986. Polyamine titre in relation to chill-sensitivity in Phaseolus sp. —J. exp. Bot. 37: 1036-1043. Endogenous levels of the polyamines putrescine, spermidine and spermine were quantified in the primary leaves of five cultivars of bean (Phaseolus sp.) differing in their 'wilting response' to a chilling exposure of 5 °C for 24 h. Levels of polyamines prior to chilling treatment did not appear to be correlated with chill-tolerance as levels in the non-chilled controls were highest in cultivars of medium chill-sensitivity. Plants grown under a vapour saturation deficit (PSD) of 8-4 g m ~ 3 day/6-1 g m ~ 3 night exhibited a mild hardening as compared to plants grown under a VSD of 5-7 g m"3 day/4-1 g m ~3 night, as the former showed less wilting on chilling. Hardening at high VSD had the effect of slightly lowering the putrescine content of non-chilled tissue but total polyamine content remained unchanged. However, on chilling, the largest relative increase in polyamine levels, in particular that of putrescine, occurred in hardened plants. There was also a significant relative increase in putrescine titre in response to chilling in non-hardened genotypes of high chill-tolerance, whereas more chill-sensitive genotypes remained unchanged or slightly declined in putrescine content on chilling. Relative changes in putrescine content rather than absolute levels appears to be correlated with chill-tolerance. These results are discussed in view of present knowledge on the adaptive significance of stress-induced changes in polyamines, especially with regard to membrane stability.
Novel cucurmosin‐based immunotoxin targeting programmed cell death 1‐ligand 1 with high potency against human tumor in vitro and in vivo

Immunotoxins are Ab‐cytotoxin chimeric molecules with mighty cytotoxicity. Programmed cell death 1‐ligand 1 (PD‐L1), is a transmembrane protein expressed mainly in inflammatory tumor tissues and plays a pivotal role in immune escape and tumor progression. Although PD‐L1 immune checkpoint therapy has been successful in some cases, many patients have not benefited enough due to primary/secondary resistance. In order to optimize the therapeutic efficacy of anti‐PD‐L1 mAb, we used durvalumab as the payload and CUS245C, a type I ribosome‐inactivating protein isolated from Cucurbita moschata, as the toxin moiety, to construct PD‐L1‐specific immunotoxin (named D‐CUS245C) through the engineered cysteine residue. In vitro, D‐CUS245C selectively killed PD‐L1+ tumor cells. In vivo studies also showed that D‐CUS245C had obvious antitumor effect on PD‐L1+ human xenograft tumors in nude mice. In conclusion, in the combination of the toxin with mAb, this study developed a new immunotoxin targeting PD‐L1, emphasizing a novel and promising treatment strategy and providing a valuable way to optimize cancer immunotherapy.
Improving Spatial Resolution of Multispectral Rock Outcrop Images Using RGB Data and Artificial Neural Networks

Spectral information provided by multispectral and hyperspectral sensors has a great impact on remote sensing studies, easing the identification of carbonate outcrops that contribute to a better understanding of petroleum reservoirs. Sensors aboard satellites like Landsat series, which have data freely available usually lack the spatial resolution that suborbital sensors have. Many techniques have been developed to improve spatial resolution through data fusion. However, most of them have serious limitations regarding application and scale. Recently Super-Resolution (SR) convolution neural networks have been tested with encouraging results. However, they require large datasets, more time and computational power for training. To overcome these limitations, this work aims to increase the spatial resolution of multispectral bands from the Landsat satellite database using a modified artificial neural network that uses pixel kernels of a single spatial high-resolution RGB image from Google Earth as input. The methodology was validated with a common dataset of indoor images as well as a specific area of Landsat 8. Different downsized scale inputs were used for training where the validation used the ground truth of the original size images, obtaining comparable results to the recent works. With the method validated, we generated high spatial resolution spectral bands based on RGB images from Google Earth on a carbonated outcrop area, which were then properly classified according to the soil spectral responses making use of the advantage of a higher spatial resolution dataset.
Twos in human visual perception

Human vision serves the social function of detecting and discriminating with high efficiency conspecifics and other animals. The social world is made of social entities as much as the relations between those entities. Recent work demonstrates that vision encodes visuo-spatial relations between bodies with the same efficiency and high specialization of face/body perception. Specifically, perception of face-to-face (vs. non-facing) bodies evokes effects compatible with the most robust markers of face-specificity such as the behavioral inversion effect and increased activity in selective visual areas. Another set of results suggests that face-to-face bodies are processed as a grouped unit, analogously to facial features in a face. The facing dyad in the visual cortex may be the earliest rudimentary representation of social interaction.
Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel β coronavirus that is the etiological agent of the pandemic coronavirus disease 2019 (COVID-19) that at the time of writing (June 16, 2020) has infected almost 6 million people with some 450,000 deaths. These numbers are still rising daily. Most (some 80%) cases of COVID-19 infection are asymptomatic, a substantial number of cases (15%) require hospitalization and an additional fraction of patients (5%) need recovery in intensive care units. Mortality for COVID-19 infection appears to occur globally between 0.1 and 0.5% of infected patients although the frequency of lethality is significantly augmented in the elderly and in patients with other comorbidities. The development of acute respiratory distress syndrome and episodes of thromboembolism that may lead to disseminated intravascular coagulation (DIC) represent the primary causes of lethality during COVID-19 infection. Increasing evidence suggests that thrombotic diathesis is due to multiple derangements of the coagulation system including marked elevation of D-dimer that correlate negatively with survival. We propose here that the thromboembolic events and eventually the development of DIC provoked by SARS-CoV-2 infection may represent a secondary anti-phospholipid antibody syndrome (APS). We will apply both Baconian inductivism and Cartesian deductivism to prove that secondary APS is likely responsible for coagulopathy during the course of COVID-19 infection. Diagnostic and therapeutic implications of this are also discussed.
Fostering Broad Oral Language Skills in Preschoolers from Low SES Background

Socioeconomic disparities increase the probability that children will enter school behind their more advantaged peers. Early intervention on language skills may enhance language and literacy outcomes, reduce the gap and, eventually, promote school readiness of low-SES (Socioeconomic Status) children. This study aimed to analyze the feasibility and effectiveness of a brief narrative-based intervention (treatment vs. control group) aimed to foster broad oral language skills in preschoolers (N = 69; Mean age = 5.5, SD = 4 months) coming from low-SES families. Moreover, it was analyzed whether children’s initial vocabulary mediates the intervention’s responsiveness. Results have shown that children in treatment group obtained greater gains than children in control group in almost all intervention-based measures. There is also some evidence for the generalizability of the intervention to other skills not directly trained during the intervention. Moreover, it was found that children’s initial vocabulary mediates the intervention’s responsiveness showing that children with high vocabulary made greater gains in higher-level components of language comprehension, whereas children with low vocabulary made higher gains in vocabulary. Taken together, our findings suggest that a relatively brief, but quite intensive narrative-based intervention, may produce improvements on broad oral language skills in preschoolers from low-SES backgrounds.
Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study

Abstract Background Gastro-oesophageal reflux disease (GORD) is associated with multiple risk factors but determining causality is difficult. We used a genetic approach [Mendelian randomization (MR)] to identify potential causal modifiable risk factors for GORD. Methods We used data from 451 097 European participants in the UK Biobank and defined GORD using hospital-defined ICD10 and OPCS4 codes and self-report data (N = 41 024 GORD cases). We tested observational and MR-based associations between GORD and four adiposity measures [body mass index (BMI), waist–hip ratio (WHR), a metabolically favourable higher body-fat percentage and waist circumference], smoking status, smoking frequency and caffeine consumption. Results Observationally, all adiposity measures were associated with higher odds of GORD. Ever and current smoking were associated with higher odds of GORD. Coffee consumption was associated with lower odds of GORD but, among coffee drinkers, more caffeinated-coffee consumption was associated with higher odds of GORD. Using MR, we provide strong evidence that higher WHR and higher WHR adjusted for BMI lead to GORD. There was weak evidence that higher BMI, body-fat percentage, coffee drinking or smoking caused GORD, but only the observational effects for BMI and body-fat percentage could be excluded. This MR estimated effect for WHR equates to a 1.23-fold higher odds of GORD per 5-cm increase in waist circumference. Conclusions These results provide strong evidence that a higher waist–hip ratio leads to GORD. Our study suggests that central fat distribution is crucial in causing GORD rather than overall weight.
Ultrastructural and Photosynthetic Responses of Pod Walls in Alfalfa to Drought Stress

Increasing photosynthetic ability as a whole is essential for acquiring higher crop yields. Nonleaf green organs (NLGOs) make important contributions to photosynthate formation, especially under stress conditions. However, there is little information on the pod wall in legume forage related to seed development and yield. This experiment is designed for alfalfa (Medicago sativa) under drought stress to explore the photosynthetic responses of pod walls after 5, 10, 15, and 20 days of pollination (DAP5, DAP10, DAP15, and DAP20) based on ultrastructural, physiological and proteomic analyses. Stomata were evidently observed on the outer epidermis of the pod wall. Chloroplasts had intact structures arranged alongside the cell wall, which on DAP5 were already capable of producing photosynthate. The pod wall at the late stage (DAP20) still had photosynthetic ability under well-watered (WW) treatments, while under water-stress (WS), the structure of the chloroplast membrane was damaged and the grana lamella of thylakoids were blurry. The chlorophyll a and chlorophyll b concentrations both decreased with the development of pod walls, and drought stress impeded the synthesis of photosynthetic pigments. Although the activity of ribulose-1,5-bisphosphate carboxylase (RuBisCo) decreased in the pod wall under drought stress, the activity of phosphoenolpyruvate carboxylase (PEPC) increased higher than that of RuBisCo. The proteomic analysis showed that the absorption of light is limited due to the suppression of the synthesis of chlorophyll a/b binding proteins by drought stress. Moreover, proteins involved in photosystem I and photosystem II were downregulated under WW compared with WS. Although the expression of some proteins participating in the regeneration period of RuBisCo was suppressed in the pod wall subjected to drought stress, the synthesis of PEPC was induced. In addition, some proteins, which were involved in the reduction period of RuBisCo, carbohydrate metabolism, and energy metabolism, and related to resistance, including chitinase, heat shock protein 81-2 (Hsp81-2), and lipoxygenases (LOXs), were highly expressed for the protective response to drought stress. It could be suggested that the pod wall in alfalfa is capable of operating photosynthesis and reducing the photosynthetic loss from drought stress through the promotion of the C4 pathway, ATP synthesis, and resistance ability.
Death, discharge and arrhythmias among patients with COVID-19 and cardiac injury

BACKGROUND: Cardiac injury is common in severe coronavirus disease 2019 (COVID-19) and is associated with poor outcomes. We aimed to study predictors of in-hospital death, characteristics of arrhythmias and the effects of QT-prolonging therapy in patients with cardiac injury. METHODS: We conducted a retrospective cohort study involving patients with severe COVID-19 who were admitted to Tongji Hospital in Wuhan, China, between Jan. 29 and Mar. 8, 2020. Among patients who had cardiac injury, which we defined as an elevated level of cardiac troponin I (cTnI), we identified demographic and clinical characteristics associated with mortality and need for invasive ventilation. RESULTS: Among 1284 patients with severe COVID-19, 1159 had a cTnI level measured on admission to hospital, of whom 170 (14.7%) had results that showed cardiac injury. We found that mortality was markedly higher in patients with cardiac injury (71.2% v. 6.6%, p < 0.001). We determined that initial cTnI (per 10-fold increase, hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.06–1.66) and peak cTnI level during illness (per 10-fold increase, HR 1.70, 95% CI 1.38–2.10) were associated with poor survival. Peak cTnI was also associated with the need for invasive ventilation (odds ratio 3.02, 95% CI 1.92–4.98). We found arrhythmias in 44 of the 170 patients with cardiac injury (25.9%), including 6 patients with ventricular tachycardia or fibrillation, all of whom died. We determined that patients who received QT-prolonging drugs had longer QTc intervals than those who did not receive them (difference in medians, 45 ms, p = 0.01), but such treatment was not independently associated with mortality (HR 1.04, 95% CI 0.69–1.57). INTERPRETATION: We found that in patients with COVID-19 and cardiac injury, initial and peak cTnI levels were associated with poor survival, and peak cTnI was a predictor of need for invasive ventilation. Patients with COVID-19 warrant assessment for cardiac injury and monitoring, especially if therapy that can prolong repolarization is started. Trial registration: Chinese Clinical Trial Registry, No. ChiCTR2000031301.
Can We Still Use PEAQ? A Performance Analysis of the ITU Standard for the Objective Assessment of Perceived Audio Quality

The Perceptual Evaluation of Audio Quality (PEAQ) method as described in the International Telecommunication Union (ITU) recommendation ITU-R BS.1387 has been widely used for computationally estimating the quality of perceptually coded audio signals without the need for extensive subjective listening tests. However, many reports have highlighted clear limitations of the scheme after the end of its standardization, particularly involving signals coded with newer technologies such as bandwidth extension or parametric multi-channel coding. Until now, no other method for measuring the quality of both speech and audio signals has been standardized by the ITU. Therefore, a further investigation of the causes for these limitations would be beneficial to a possible update of said scheme. Our experimental results indicate that the performance of PEAQ's model of disturbance loudness is still as good as (and sometimes superior to) other state-of-the-art objective measures, albeit with varying performance depending on the type of degraded signal content (i.e. speech or music). This finding evidences the need for an improved cognitive model. In addition, results indicate that an updated mapping of Model Output Values (MOVs) to PEAQ's Distortion Index (DI) based on newer training data can greatly improve performance. Finally, some suggestions for the improvement of PEAQ are provided based on the reported results and comparison to other systems.