Miracle-dz/UniFAR-FTUs huggingface dataset:
A Case Report of a Metastatic Adenocarcinoma of Lung with Dual Positivity for EGFR Mutation and ALK Fusion

Non-small cell lung cancer ranks among the most lethal cancers worldwide. The rate of epidermal growth factor receptor (EGFR) mutations and echinoderm microtubuleassociated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) gene fusion is the most common in younger age, non-smoking Asian adenocarcinoma lung cancer patients. EGFR mutations and ALK gene rearrangements are known to be mutually exclusive and as mutual causes of resistance to EGFR-tyrosine kinase inhibitors (TKIs) or ALK-TKIs. However, rarely such co-alterations do co-exist in some clinical cases. Here we report a 62 year old male, heavy smoker with cough, hemoptysis and fatigue. Histopathological examination of bronchoscopic guided biopsy showed adenocarcinoma histology. Staging evaluation, he was found to have stage IV disease on positron emission tomography-computed tomography scan. The biopsy blocks tested positive for both EGFR mutation and ALK fusion. Patient was initiated on tablet Gefitinib 250 mg once daily. To the best of our knowledge, there has been no report of dual EGFR mutation and ALK fusion positivity from India.
The impact of early institutional deprivation on brain structure and structural covariance in young adulthood

4 When we tested for brain-behaviour relationships, a range of patterns were observed: Smaller brain volume was associated with increased risk of disinhibited social engagement symptoms and low IQ. In contrast, deprivation-related alterations of the right inferior frontal and temporal cortices were related to more effective proactive inhibition and better prospective memory and fewer ADHD symptoms, respectively suggestive of neural compensation of either a latent (affecting underlying cognitive processes only) or fully manifest nature (reduced risk of disorder symptoms). There was also evidence of deprivation potentially creating latent vulnerability for future disorder with deprivation-related increases in right anterior cingulate volume associated with impaired empathic accuracy. In addition to these effects in regions of interest, on a whole-brain level, deprivation moderated the association between brain structure and symptoms of ADHD, ASD and IQ. Most striking was increased gyrification in those with high levels of ADHD symptoms who had experienced extended deprivation. This provides preliminary evidence that deprivation-related symptoms may have different neurobiological signatures compared to non-deprivation-related symptoms. Early institutional deprivation was also associated with alterations in structural covariance of cortical thickness and surface area with those having experienced more than 6 months deprivation demonstrating both increased as well as decreased correlation strengths between frontal and temporal brain regions with distinct changes for cortical thickness and surface area. These findings stress that deprivation may lead to brain structural alterations which in part reflect changes in coordinated brain network development, with the right fronto-temporal regions being most sensitive to deprivation. Together, these findings provide compelling evidence that early institutional deprivation has strong neurobiological programming effects on brain development. It highlights how early adverse environments during sensitive periods of heightened
The Effect of Owner-Based and Lender-Based Governance Mechanisms on the Financial Performance of Listed Companies in Sri Lanka

This study examines the effects of both Owner-based and Lender-based governance mechnisms on the firm financial performance in terms of three aspects, namely profitability, firm value and firm survival. From the Colombo Stock Exchange, the current study selected a sample of 100 listed entities in which the debt capital is a key source of financing. The results indicate that Owner-Governance mechanisms would enhance the firm profitability where, Lender-Governance mechanisms deteriorate it. However, the latter aids sustain the corporates, by attenuating firm distress level. In conclusion, the two types of corporate financiers have got divergent expectations which they try to assure through their own governance mechanisms over the entity (investee), as reflected through different effects on three aspects of firm financial performance. Thus, both governance mechanisms need to be considered as important factors in determining the different aspects of firm financial performance.
Effects of acute caffeine on muscle damage biomarkers and time to exhaustion after a single session of resistance exercises followed by exhaustive incremental test in long-distance runners

The present study was designed to investigate the acute effect of caffeine on muscle damage biomarkers (creatine kinase, lactate dehydrogenase, creatine kinase MB, and myoglobin) measured before, immediately after, and 24 h after a single session of resistance exercises followed by exhaustive incremental test. In addition, the effect of caffeine intake on time to exhaustion during exhaustive incremental test was determined. Fifteen male long-distance runners (30.67 ± 3.40 yrs.) performed two consecutive trials (7 days apart). Athletes were assigned randomly either to ingest caffeine (6 mg/kg) 1 h prior to exercise or placebo using a double-blind crossover design. Each trial consisted of 5 resistance exercises followed by exhaustive incremental test. Blood samples were collected before, immediately, and 24 h after each trial. The independent t test of data showed no significant differences in biomarkers of muscle damage at all time points between trials ( p > .05). Using paired sample t test, data revealed that caffeine increased the time to exhaustion (45.78 ± 2.42 min) during exhaustive incremental test compared to the placebo (43.83 ± 2.21 min) ( p = .001). In conclusion, 6 mg/kg of caffeine 1 hour prior to resistance exercises followed by exhaustive incremental test had no effect on muscle damage biomarkers in long-distance runners probably due to mechanical stress precisely affected fast twitch fibres rather than slow twitch fibres. However, the increased time to exhaustion due to caffeine consume may attributed to dampened pain sensation.
The factors effecting entrepreneurial intention of university students: case of Mongolia

Small and medium sized businesses with entrepreneur orientation have been developing rapidly creating wealth for the nations and often become large global enterprises. The researches on the entrepreneur intention, entrepreneur education, attitude as well as the factors affecting to them are getting popular. Simultaneously, the study on whether the university is nurturing the entrepreneur intention, attitude or boosts students’ willingness starting their own businesses has been remaining an interesting topic. The current study aimed at researching various factors affecting the entrepreneur intention, attitude of the students, subjective norms, entrepreneur education, and perceived behaviour control using sample survey involving 568 university students. The survey results demonstrated that the personal attitude had an influence on entrepreneur intention and the participants expressed their willingness starting their own businesses having an awareness on prospective challenges and opportunities. The determinants such as subjective norms and perceived behaviour control had both positive impacts on becoming an entrepreneur; however, an entrepreneur education demonstrated a slight impact in entrepreneur intention.
Energy Efficiency Optimization for MIMO Visible Light Communication Systems

Multiple-input multiple-output (MIMO) visible light communication (VLC) systems can support high data rates for indoor communications. In this letter, we focus on maximizing the energy efficiency (EE) of MIMO VLC systems, where the non-negativeness of the transmit signal, the optical and electrical power constraints, and the data rate and bit error rate (BER) requirements are taken into account. The formulated problem is a difficult nonlinear fractional program. We exploit the Dinkelbach’s algorithm and Lagrangian analysis to obtain a semi-closed form solution. The performance advantage of the proposed design is verified by simulation results.
Uncovering Implicit Assumptions: Reviewing the Work–Family Interface in Family Business and Offering Opportunities for Future Research

The work–family interface (WFI) in family businesses (FBs) is an underrecognized area of research. The permeable nature of the boundaries in FBs between work and family is often treated as self-evident and as preventing (rather than inviting) research. We review the WFI in FBs based on 72 published articles and highlight implicit assumptions that have given rise to gaps in this literature. We show how boundary theory, the work–home resources model and the resource-based view can be used to highlight issues related to ownership, work–family enrichment, and contextual factors at the individual, family, and firm domains.
Analysis of risk factors behind keloid

Background: Keloids are firm, thickened, bosselated tumors with fibrous tissue which expands beyond the original injury with common sites being presternum, shoulder, ear lobes. They are more common in Blacks and Hispanics than Caucasians. As there is paucity of studies from South India, this study is done to identify the epidemiological features and analyse the risk factors involved in keloid formation and compare it with previous studies. Methods: 60 subjects were included in the study. Keloid was diagnosed clinically and factors such as the age at presentation, gender, site, size, duration, number and predisposing factors to keloid formation were assessed among them for a period of 18 months. Results: Most of the patients were in the age group of 20-40 years and maximum were females. Majority of patients around 51.67% were affected in chest followed by shoulder (20%). In our study 61.67% patients had keloids of size ≤5 cm and 23 (38.33%) patients had size >5 cm. Most of the patients (41.67%) had keloids of <2 years duration. Maximum number of the patients (68%) had single keloid. 50% of the patients had keloids which occurred after trauma followed by acne (15%), surgery (10%) and herpes zoster (10%), burns (5%). 10% of the patients had spontaneous onset of keloids. Conclusions: The epidemiological features found in this study were similar to the studies conducted in the different parts of the world. Elimination of exacerbating factors will prevent further keloid formation thereby playing a crucial role in the management.
Thermospheric Composition O/N
 2 Response to an Altered Meridional Mean Circulation During Sudden Stratospheric Warmings Observed by GOLD

Observations from the recently launched Global‐Scale Observations of the Limb and Disk (GOLD) instrument on the geostationary SES‐14 communications satellite reveal a substantial response of the mean state of the thermosphere to the Sudden Stratospheric Warming (SSW) event in early January 2019. The observed O/N 2 column density depletion of more than 10% starts at the onset of the SSW, maximizes at the time of the stratospheric wind reversal, and recovers toward the end of the SSW. A connection between SSW and thermospheric composition was previously predicted by model simulations but could not be observed before. The GOLD measurements support the scenario that enhanced global‐scale wave activity during SSWs causes an enhanced wave driving of the lower thermosphere zonal mean circulation that leads to a reduction in lower thermosphere atomic oxygen, which then propagates through molecular diffusion into the upper thermosphere.
The Relationship between Malnutrition Markers and Nutritional Status among Pregnant and Lactating Qashqa'i Nomad Mothers in Fars-Iran Running Title: Malnutrition Markers And Nutritional Status In Qashqa'i Nomad Mothers

Today, malnutrition among the suburban and a large number of rural populations is a controversial issue in science and health conferences. We examined the correlation between malnutrition markers and nutritional status in pregnant and lactating Qashqa'i nomad mothers in Iran. A cross-sectional study was carried out among 930 pregnant and lactating Qashqa'i mothers by random sampling method. These women who had less than eight pregnancies (pregnant for three months or lactating after three months of birth) were assessed with anthropometric methods (Body Mass Index), nutritional intake assessment and biochemical tests (Serum Albumin, Hemoglobin, Protein). The data were analyzed by SPSS software, using ANOVA and regression tests. The average age of mothers was 24.3 ± 5.3. In %21 of these mothers, BMI was less than 18.5 kg/m2. The total serum protein in 3.4% of them was less than 6 g/dl, in 19.3% of them serum albumin was less than 3.6 g/dl, and in %19.3 of them mean hemoglobin concentration was less than 11 g/dl. 26% of them had low energy intake, 11% of protein intake, and 24% of ferrous. There was a significant correlation between protein intake and total serum protein (r = 0.89, p = 0.015) and serum albumin (r = 0.93, p= 0.005). The data suggest that high intakes of protein is associated with higher levels of serum protein and serum albumin and through an optimized diet consisting of available food resources in nomadic lifestyle, malnutrition specially protein deficiency can be minimized with the least cost.
Gangliocytoma Combined with a Pituitary Adenoma: Reports of Three Cases and Literature Review

Objectives Sellar gangliocytomas are extremely rare. Since they present clinically and radiologically as pituitary adenomas, the preoperative diagnosis of these mixed tumors is very difficult. Here, we report three cases of gangliocytoma combined with pituitary adenoma and describe our findings. Methods The clinical data of the three cases of gangliocytoma combined with pituitary adenoma have been retrospectively analyzed, and the published literature has also been reviewed. Results All three patients underwent pure endonasal endoscopic surgery, and no recurrence was observed over a follow-up of at least 30 months. Growth hormone (GH)-hypersecreting adenoma and tumor calcification were detected in these mixed tumors. Conclusions Pure endoscopic transnasal transsphenoidal surgery may be an effective way for the treatment of this kind of tumor. Gross total resection of the tumor is recommended. In addition, calcification with GH-hypersecretion may serve as a preoperative diagnostic clue for gangliocytoma in the sella turcica.
The Effectiveness of Library Instruction for Graduate/Professional Students: A Systematic Review and Meta-Analysis

Abstract Objective - This study sought to assess the effectiveness of library instruction for increasing information literacy skills and/or knowledge among graduate and professional students. Methods - A search was conducted in Library Literature and Information Science Index (H. W. Wilson); Library, Information Science & Technology Abstracts; Medline; CINAHL; ERIC; Library and Information Science Abstracts (LISA); and ProQuest Dissertations and Theses Global. Studies were included if they were published between 2000 and 2019, in English, reported on library instruction for graduate or professional students, and objectively measured change in information literacy knowledge/skills. Results - Sixteen studies were included in the systematic review; 12 of the 16 studies included sufficient information to be included in the meta-analysis. The overall effect of library instruction was significant [SMD = 1.03, SE=0.19, z=5.49, P<. 0001, 95% CI=0.66-1.40], meaning that on average, a student scored about one standard deviation higher on an information literacy assessment after library instruction. High heterogeneity indicated a need for subgroup analysis, which showed a significant moderation of effect by discipline of students, but none by format of instruction. However, subgroup analysis must be viewed with caution due to the small number of studies in several of the subgroups. Conclusions - This meta-analysis indicates that library instruction for graduate students is effective in increasing information literacy knowledge and/or skills. However, to strengthen the accuracy of results of future meta-analyses, there is a need for more precise descriptions of instructional sessions as well as more complete data reporting by authors of primary studies. There is also a need for the publication of more studies, particularly studies of hybrid and online instruction.
Prediction of 3-D Ocean Temperature by Multilayer Convolutional LSTM

Sea surface temperature (SST) prediction has raised considerable attention in various ocean-related fields. However, these methods were only limited to the time-sequence prediction of some isolated points, and their spatial linkage was not considered. Furthermore, these studies only predict the temperature of sea surface, but the subsurface temperature in the inner ocean is much more important. In this letter, we propose a model of multilayer convolutional long- and short-term memory (M-convLSTM) to predict 3-D ocean temperature, comprising convolutional neural networks (CNNs), long- and short-term memory (LSTM), and multiple layer stacking to consider the horizontal and vertical temperature variations from sea surface to subsurface to be about 2000 m below. Global marine environment observation data (ARGO) are used to conduct the prediction of 3-D ocean temperature in this letter, and the results demonstrate the overall good accuracy of forecast and ARGO data.
Risk and Competition in the Indonesian Private Banking Market: An Asymmetric Rivalry Within and Between Strategic Groups

This paper tests the interrelationships among risk, competition, and efficiency in the Indonesian private banking industry between 2014 and 2018. We examines asymmetric rivalry within and between strategic groups defined according to the size of their members. We hypothesize that, owing to several forms of group-level effects, including price difference and efficiency, strategic groups comprising large firms expect to experience a large amount of retaliation from firms within their group and accommodation from the group comprising smaller firms. The competition of private banking is dominated by incumbent firm. The risk and efficiency evolved over time enjoyed by incumbent with fat cat taxonomy and quiet life hypothesis. The entrant play lean and hungry strategy in different market segment within strategic group, whereas foreign bank deter incumbent with higher prices to enter between strategic group. The competition of private banking in Indonesia dominated by risk appetite and fragmented market
Students and teachers’ necessity toward virtual laboratory as an instructional media of 21st century science learning

This research aims to determine the needs a virtual laboratory. The research used survey method. Instrument used were questionnaires for both teacher and students. The research used 2 class grade VII total 67 students which choosen by purposive sampling and 2 science teachers in Junior High School 6 Yogyakarta. The questionnaires were analyzed by percentage and interview analyzed by descriptively. The questionnaires contains about science learning in school, science practicum in school, the use of technology in learning, and media virtual laboratory needed in learning. The interview consist of student learning outcomes, media that are commonly used in learning, implementation of science practicum, and the needs of the virtual laboratory. The result show that 94,3% students need virtual laboratory media should be developed to supporting media for the science practicum activities. This condition was supported by interview, teachers assume that with a virtual laboratory in which there are material, videos, pictures, and simulations make students not only understand the theory but students can do practicum virtually. The teacher states that it is necessary to develop a virtual laboratory media to overcome the constraints of science practicum in schools because of that students and teachers need virtual laboratory in science learning.
Heart Failure And Ejection Fraction

Heart failure (HF) is a complex clinical syndrome that results from either functional or structural impairment of ventricles resulting in symptomatic left ventricle (LV) dysfunction. The symptoms come from an inadequate cardiac output, failing to keep up with the metabolic demands of the body. It is a leading cause of cardiovascular morbidity and mortality worldwide despite the advances in therapies and prevention. It can result from disorders of the pericardium, myocardium, endocardium, heart valves, great vessels, or some metabolic abnormalities.DefinitionThree main phenotypes describe HF according to the measurement of the left ventricle ejection fraction (EF) and the differentiation between these types is important due to different demographics, co-morbidities, and response to therapies:All patients with HFrEF have concomitant diastolic dysfunction; in contrast, diastolic dysfunction may occur in the absence of systolic dysfunction.
A Hybrid Method for Brain Tumor Detection using Advanced Textural Feature Extraction

Brain tumors vary in their position, mass, nature, and consistency of these lesions. Due to the similarities found between brain lesions and normal tissues, many challenges are faced by the researcher in developing algorithms for tumor segmentation.Brain tumor abstraction is thought-provoking job in medical image handing out because brain image and its structure is complicated. Segmentation plays a vibrant role in processing of medical images. Magnetic Resonance Imaging has become a particularly useful medical diagnostic tool for diagnosis of brain and other medical images. The objective of this paper is to develop an algorithm that facilitates the study off eature extraction from the brain right and left hemispheres.The proposed study, also highlight a completely different advanced higher order statistical features extracted from the chosen region of brain slice. The tumor area is extracted from statistical features using Support Vector Machine. The proposed methodology can be used to locate tumor tissues based on a single-spectral structural Magnetic resonance image.
The Interaction Between Genetics and Tobacco Consumption in Light Smokers

Smoking is the largest preventable cause of death globally. In North America, although the overall smoking prevalence has been declining, an increasing number of smokers consume less than 10 cigarettes per day and are referred to as light smokers. Today, light smokers represent more than 30% of the smoking population and are at risk for smoking related mortality and morbidity. For example, light smokers have approximately 15 times higher risk of developing chronic obstructive pulmonary disease and approximately 20 times higher risk of developing lung cancer compared to non-smokers. Yet despite the high prevalence and substantial negative health consequences, light smokers are generally excluded from smoking related studies. Genetic variants in CYP2A6, encoding for the major nicotine-metabolizing enzyme, and CHRNA5-A3B4, encoding for α5, α3 and β4 nicotinic receptors, are associated with altered tobacco consumption in heavy smokers, yet little is known about the influence of CYP2A6 and CHRNA5A3-B4 genetic variants on tobacco consumption and smoking cessation in light smokers. In a cross sectional study of 400 Alaska Native individuals, we demonstrated that light smokers had similar nicotine exposure (as indicated by their urinary total nicotine equivalents) as heavy smokers despite self-reporting lower number of cigarettes per day. Like heavy smokers, these