Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment Of Sustainability Tradeoffs In Renewable Energy Generation And Additive Manufacturing

Renewable energy generation and additive manufacturing are becoming more widespread, in part because of their sustainability benefits, where sustainability is measured by its environmental, economic and social attributes. The first part of the dissertation explores the economic and environmental tradeoffs of using energy generated by onsite roof-mounted high efficiency solar panels to power manufacturing facilities. The System Advisor Model (SAM) was used to investigate viability of solar irradiance for facilities across all of the industrial sectors in all U.S. states using the Manufacturing Energy Consumption Survey (MECS) database. Five case studies further explore the economic feasibility and environmental implications of installing onsite roof-mounted high efficiency solar PV systems for industrial facilities in five select U.S. states (California, Florida, Indiana, New Jersey, and Texas), which have varying levels of solar irradiance, different incentives, and solar policies. Results indicate that lower Levelized Cost of Energy (LCOE) and positive Net Present Value (NPV) can be achieved under certain conditions with the economic payback time ranging from 3 to 15 years. Energy Pay Back Time (EPBT) could
Attentional Focus for Maximizing Muscle Development: The Mind-Muscle Connection

ABSTRACTATTENTIONAL FOCUS IS A WELL-RECOGNIZED ASPECT OF MOTOR LEARNING AND ITS USE HAS IMPORTANT IMPLICATIONS TO THE FITNESS PROFESSIONAL. THIS ARTICLE WILL DISCUSS HOW ATTENTIONAL FOCUS SHOULD BE DIRECTED TO MAXIMIZE MUSCULAR DEVELOPMENT.
Comparative evaluation of the efficacy of 4% articaine and 2% lidocaine in children during the primary maxillary molar extractions

Aims: This study aims to compare and evaluate the efficacy of 4% articaine and 2% lidocaine in children during the primary maxillary molar extractions. Materials and Methods: A total of 102 patients were randomly selected for the study who required maxillary molar extractions and received buccal infiltration either using lidocaine or articaine. Results: Higher mean value for facial pain scale for lidocaine suggesting lesser effectiveness of infiltration was seen in the results. Statistically insignificant changes were seen in heart rate, blood pressure, and difference in Face, Legs, Activity, Cry, and Consolability Scale between articaine and lidocaine. Higher pain scores with lidocaine compared to articaine are shown in the results of the study but are not statistically significant. Conclusions: It can be concluded that articaine is better alternative to lidocaine for local anesthesia in pediatric patients.
Job Stress and Job Satisfaction Among Indonesian Lecturers: How Information Technology System May Define Them in the Era of Industrial Revolution 4.0

— Information technology is developing rapidly and has changed the way of life in all elements of society, including in tertiary organizations. This study aimed to determine the contribution of information technology systems in strengthening or weakening the relationship between organizational culture and the level of satisfaction and organizational structure and stress experienced by lecturers in Indonesia. In addition this study also examined the effect of information technology systems on stress and the effect of stress on job satisfaction. The population in this study were lecturers of state universities in Indonesia with a sample of 106 lecturers from ten universities spread across three clusters of Indonesia, Java and Bali, Sumatra and Sulawesi. The instrument was a Likert scale online questionnaire processed with the analysis tool WarpPLS 6.0. The findings of this study showed there was a contribution of information technology systems to the effect of organizational culture on job satisfaction. However, information technology systems failed to moderate the effect of organizational structure on stress levels. On the other hand, information technology systems had a direct and negative effect on stress and stress had a negative effect on job satisfaction. Some recommendations for increasing job satisfaction and reducing stress of lecturers in Indonesia are discussed in this study.
Complications of Systemic Lupus Erythematosus in the Emergency Department

S ystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the chronic activation of the immune system, leading to the formation of autoantibodies and multi-organ damage. The prevalence of SLE in the United States is 20 to 150 per 100,000 persons.1 Ninety percent of patients with SLE are women, and the condition is more common and often more severe among patients of black African or of Asian descent. The most common symptoms of SLE are constitutional (fever or weight loss), musculoskeletal (arthralgias or myalgias), and dermatological (malar rash, photosensitive rash, discoid lupus, or oral ulcers). However, since SLE is known to affect nearly every organ system, clinical manifestations may differ markedly among patients (Table). For patients with known SLE who present to the ED, it can be a challenge to identify whether their symptoms are due to a
Early Pregnancy Diagnosis in Graded Murrah Buffaloes Using Elisa Based Serum Progesterone Assay

The present investigation was conducted to study the accuracy of serum progesterone assay in diagnosing early pregnancy. Twenty healthy graded Murrah buffalo cows aged 4-8years were selected and inseminated using frozen semen upon observation of heat signs. They were subjected to early pregnancy diagnosis on 21d post insemination using ELISA based serum progesterone assay. Out of 20 buffaloes tested for serum progesterone concentration, 9 (45%) were diagnosed as pregnant and 11 (55%) as non pregnant. The animals were diagnosed pregnant and non pregnant if the progesterone values were 2.5 or >2.5 ng/ml and <2.5ng/ml, respectively and the progesterone concentrations in the buffaloes found pregnant ranged between 2.54 to 7.63 ng/ml and the same in non pregnant buffaloes ranged between 0.63 to 1.9 ng/ml. Serum progesterone concentration of pregnant and non pregnant animals differs significantly (P<0.05). From this study it was concluded that serum progesterone assay was 80 per cent accurate in diagnosing early pregnancy and 90 per cent for non pregnancy with an overall diagnostic accuracy of 85.0 per cent.
Improved survival with MEK Inhibition in BRAF-mutated melanoma for the METRIC Study Group

Background Activating mutations in serine–threonine protein kinase B-RAF (BRAF) are found in 50% of patients with advanced melanoma. Selective BRAF-inhibitor therapy improves survival, as compared with chemotherapy, but responses are often short-lived. In previous trials, MEK inhibition appeared to be promising in this population. Methods In this phase 3 open-label trial, we randomly assigned 322 patients who had metastatic melanoma with a V600E or V600K BRAF mutation to receive either trametinib, an oral selective MEK inhibitor, or chemotherapy in a 2:1 ratio. Patients received trametinib (2 mg orally) once daily or intravenous dacarbazine (1000 mg per square meter of body-surface area) or paclitaxel (175 mg per square meter) every 3 weeks. Patients in the chemotherapy group who had disease progression were permitted to cross over to receive trametinib. Progression-free survival was the primary end point, and overall survival was a secondary end point. Results Median progression-free survival was 4.8 months in the trametinib group and 1.5 months in the chemotherapy group (hazard ratio for disease progression or death in the trametinib group, 0.45; 95% confidence interval [CI], 0.33 to 0.63; P<0.001). At 6 months, the rate of overall survival was 81% in the trametinib group and 67% in the chemotherapy group despite crossover (hazard ratio for death, 0.54;95% CI, 0.32 to 0.92; P = 0.01). Rash, diarrhea, and peripheral edema were the most common toxic effects in the trametinib group and were managed with dose interruption and dose reduction; asymptomatic and reversible reduction in the cardiac ejection fraction and ocular toxic effects occurred infrequently. Secondary skin neoplasms were not observed. Conclusions Trametinib, as compared with chemotherapy, improved rates of progression-free and overall survival among patients who had metastatic melanoma with a BRAF V600E or V600K mutation. (Funded by GlaxoSmithKline; METRIC ClinicalTrials .gov number, NCT01245062.)
Linking Strategic Orientations, Dynamic Capabilities, and Firm Performance: Evidence from the Pakistani Pharmaceutical Industry

The paper aims to extend the resource-based view to dynamic capability view under dynamic environment, by investigating the effects of three strategic orientations (i.e., customer, competitor, and technology) on firm performance mediated through dynamic capabilities. A sample of 180 pharmaceutical firms of Pakistan was drawn using simple random sampling. Data was collected through a self-administrated questionnaire and analyzed using the variance-based structural equation modeling. The findings demonstrated that customer, competitor, and technology orientations have both a direct and indirect relationship with firm performance. The study offers Pakistani pharmaceutical firms a better comprehension of their strategic orientations and demonstrates how the alignment of strategic orientations with dynamic capabilities may result in better firm performance.
Drug GRADE: An Integrated Analysis of Population Growth and Cell Death Reveals Drug-Specific and Cancer Subtype-Specific Response Profiles

In the pre-clinical evaluation of anti-cancer drugs, two different measurement approaches are used: relative viability, which scores an amalgam of growth arrest and cell death, and fractional viability, which more specifically scores the degree of cell killing. In this study, we directly quantify relationships between drug-induced growth inhibition and drug-induced cell death by counting live and dead cells over time using quantitative microscopy. We find that most drugs affect both growth and death, but with different proportions and with different relative timing. These features lead to a non-uniform and unpredictable relationship between the canonical relative and fractional drug response measurements. To unify these disparate measurements, we create a new data visualization and data analysis platform, called drug GRADE, which characterizes the degree to which cell death contributes to an observed reduction in population size for any given drug. Our new method reveals both drug- and genotype-specific drug responses, which are not captured using traditional pharmaco-metrics. Taken together, this study highlights the extremely idiosyncratic nature of drug-induced growth and cell death and provides a new analysis tool for quantitatively evaluating these behaviors.
Delivery of Integrated Care Through an Outpatient Parenteral Antimicrobial Therapy Treatment Center

BackgroundThe objective of this analysis is to describe and evaluate the clinical experience of delivering outpatient parenteral antimicrobial therapy (OPAT) using the St Vincent Outpatient Treatment Center (SVOTC) as an example. With Infectious Disease of Indiana, the SVOTC offers a unique model in its integrated care delivery, staffing, and monitoring practices for patients who are discharged from the hospital but still require complex care. MethodsA retrospective cohort from the first 3 years of operation of the SVOTC (January 2010 to December 2012) was examined to determine patient characteristics, clinical characteristics, and outcome of hospital admissions during OPAT. The sample (2684 OPAT patients) comprised those patients treated with the 3 most frequently used antimicrobials in the SVOTC: ceftriaxone, daptomycin, or ertapenem. ResultsPatients were either diverted to OPAT from inpatient hospitalization (n = 1735, 65%) or initiated on OPAT directly as outpatients thereby avoiding hospitalization (n = 949, 35%). Outpatient parenteral antimicrobial therapy was delivered at the SVOTC (57%), self-administered (33%), or delivered at an external site (9%). Overall, 81 patients (3.1%) were hospitalized after being treated with OPAT, and the number of (re)admissions (admissions for those who started either as inpatients or as outpatients) was similar whether patients received OPAT after hospitalization or from the outset. The average treatment duration, including any intervening hospitalization, was 16.9 days. ConclusionsThe unique model at the SVOTC demonstrates transitional care integration in patients requiring OPAT regardless of initiation site and offers a potential mechanism to reduce cost while providing quality care.
Quality of life of patients with lower limb amputation with prostheses

Quality of life is often acknowledged as an important outcome of rehabilitation programs for people with amputation. Despite the importance of the subject, the number of studies focusing on the multiplicity of factors infl uencing this matter is still limited. These assessments are increasingly needed to demonstrate changes related to intervention over time. In order to evaluate the quality of life of patients with lower limb amputation and wearing prostheses, a study was conducted with 49 patients followed in a rehabilitation hospital in the Midwest region of Brazil. A generic instrument (Medical Outcomes Study 36-Item Short-Form Health Survey) for quality of life assessment and Trinity Amputation and Prosthesis Experience Scale-Revised that is specifi c for people with amputation were used in addition to a functional assessment measure. The results showed that the time since amputation, male gender and below-knee amputations were predictors of a better perception of quality of life and better adjustment to amputation.
Optimization of accelerated solvent extraction (ASE) of silver fir wood (Abies alba Mill.)

Qualitative and quantitative analysis of wood plant extractives depend on the efficiency of the extraction method used. The aim of this study was the application of the accelerated solvent extraction system ASE 350 to obtain hydrophilic extracts form silver fir wood (Abies alba Mill.) and optimization of the extraction protocol. Silver fir trees originated from Kočevska Reka. Dissected and milled samples of sapwood, heartwood and knots were extracted with the ASE 350 with water, ethanol (95 % aq), acetone (95 % aq) and ethyl acetate. The number of extraction cycles was determined. Analysis of extracts was done by UV/Vis spectrophotometry and HPLC. The most effective solvent for the extraction of phenolic components from heartwood was ethanol (95 % aq), in the case of sapwood water and acetone (95 % aq) in the case of knotwood. Only two 5-minute extraction cycles were required for sufficient extraction yield when using ASE 350 at 100 °C and 103.42 bar.
Dairy Cow Activity as a Potential Management Tool for Detection of Clinical Mastitis

ii Acknowledgments . iv Vita . v List of Tables . vii List of Figures . viii Chapter 1: Introduction . 1 Chapter 2: Literature Review . 3 Chapter 3: Dairy Cow Activity as a Potential Management Tool for Detection of Clinical Mastitis . 17 Chapter 4: Conclusions and Future Directions . 30 References . 32
Metabolomics in veterinary medicine: Untargeted metabolomic analysis of porcine reproductive and respiratory syndrome virus and targeted metabolomic analysis of Salmonella Enteritidis

Metabolomics is an emerging diagnostic method within veterinary medicine used to examine small molecule metabolites within bodily samples. Neither targeted nor untargeted metabolomic methods have been widely used in veterinary medicine, especially in the areas of PRRSV vaccination biomarkers or targeted metabolite kits in Salmonella Enteritidis pathogenicity. In order to evaluate the utility of untargeted metabolomics, the use of readily collectable serum and oral fluid samples were compared to characterize the metabolic changes in response to PRRSV vaccination. The samples were extracted using an RPLC method on a Thermo Fisher Dionex Ultimate 3000 UHPLC and Q Exactive Focus Quadrupole-Orbitrap mass spectrometer instrument. Mass to charge ratios (m/z) were analyzed and found to be significantly different across the experimental time course. M/z were compared to known metabolomic databases and several metabolites were identified as putative biomarkers for disease status including cytidine for serum metabolites, and protocatechuic acid and guanine for oral fluid samples. This project provides a basic proofof-concept for the application of untargeted metabolomics in veterinary diagnostic medicine, including the application of these approaches to novel oral fluid samples. However, a number of challenges were identified that will limit the approach and additional research is required to validate the utility and reliability of these metabolites as a biomarker diagnostic test. In order to demonstrate an alternate approach to veterinary infectious disease monitoring, a targeted metabolomic analysis method was used to examine poultry plasma prior to and following inoculation with Salmonella enterica serovar Enteritidis. The targeted
TEACHING EFL READING TO THE TERTIARY LEVEL STUDENTS: STUDENTS’ READING EXPECTATIONS IN THE EFL CLASSROOM

The purpose of the current paper is to find out the expectations of the tertiary level students of Bangladesh regarding EFL reading class and to what extent the expectations are met. To serve the purpose both qualitative and quantitative methods were used. The qualitative data, comprised with a questionnaire tries to locate the expectations of the first year students of the university on different perspectives. The analysis revels, the appropriate selection of texts, application of suitable reading strategies, and teachers’ adaptation of the new way to behave within the class are the most significant challenges to meet for higher academic achievement. The qualitative method is used as a form of focused group discussion to determine what facts seem important to the undergrads. Thematic analysis revels, students perceive two facts as stand points like the well maintenance of the classroom environment and appreciation of the learners’ autonomy within the classroom settings which help to promote the whole EFL reading process. The running records of the current study could be proved beneficial for the teachers along with the authority of the university to carry out the undergrads’ EFL reading expectations in the university life.
Do Shareholder Protection and Creditor Rights Have Distinct Effects on the Association Between Debt Maturity and Ownership Structure?

This study examines the effects of the firm's ownership concentration and its institutional environment on corporate debt maturity choices. As ownership concentration and debt maturity are alternative governance mechanisms, we theorize and investigate whether their association is influenced by country‐level governance factors that enhance outside monitoring by minority shareholders and debtholders. Our investigation is based on a dataset of 50,599 firm‐year observations from 38 countries. We use a propensity‐score matching approach and find that the effect of ownership concentration on debt maturity is conditional to country‐level governance attributes. Ownership concentration has a negative effect on debt maturity in countries where both shareholder protection and creditor rights are weak. Ownership concentration, however, tends to lengthen debt maturity as protection increases, and this positive effect on the length of debt maturity is stronger in countries enhancing protection towards debtholders (instead of shareholders). We also explore other characteristics of ownership structure, such as the identity and presence of controlling shareholders. These results corroborate the view that entrenched shareholders may use debt maturity opportunistically. Our study provides new insights into the interplay between firm‐ and country‐level governance mechanisms and a deeper understanding of cross‐country differences in the association between ownership structure and debt financing.
Poly-GAN: A Multi-Conditioned GAN for Multiple Tasks

We present Poly-GAN, a novel conditional GAN architecture that is motivated by different Image generation and manipulation applications like Fashion Synthesis, an application where garments are automatically placed on images of human models at an arbitrary pose, image inpainting, an application where we try to recover a damaged image using the edges or a rough sketch of the image. While different applications use different GAN setup for image generation, we propose only one architecture for multiple applications with little to no change in the pipeline. Poly-GAN allows conditioning on multiple inputs and is suitable for many different tasks. Our novel architecture enforces the conditions at all layers of the encoder and utilizes skip connections from the coarse layers of the encoder to the respective layers of the decoder. Coarse layers are easier to manipulate in shape change using condition, which results in higher level change in the result. Our system achieves state-of-the-art quantitative results on Fashion Synthesis based on the Structural Similarity Index metric and Inception Score metric using the DeepFashion dataset. For the image inpainting task we are achieving competitive results compared to current state of the art methods.
Resistance to dasatinib is associated with the activation of Akt in oral squamous cell carcinoma

Objectives: Overexpression and aberrant activation of Src promote the development of oral squamous cell carcinoma (OSCC), thus therapies targeting Src-related kinases may afford an improvement in patient survival. However, limited clinical activity of the Src-targeted drug, dasatinib, in cancer patients warrants further investigation to better understand the underlying basis of resistance to dasatinib in OSCC. Methods: Response to dasatinib was evaluated in a panel of oral cancer cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, DNA synthesis, cell cycle and apoptosis analysis. The underlying mechanism of drug response was investigated using immunoblotting. Xenograft models were used to test efficacy. Results: All cell lines were sensitive to dasatinib (IC50 < 250 nM), but this was not associated with CDKN2a/p14ARF mutations. Dasatinib-induced cell cycle arrest and apoptosis, while inhibiting Src, Akt and FAK activity in all lines tested. However, dasatinib failed to inhibit tumour growth in xenograft models and treated tissues showed Akt activity despite the loss of Src activity. Conclusions: Our data revealed that reactivation of Akt (Ser473) could be a compensatory mechanism that bypasses Src inhibition by dasatinib, providing important clues that could improve treatment strategies to overcome dasatinib resistance.
Ready for disaster: information seeking, media influence, and disaster preparation for severe weather outbreaks

ABSTRACT In light of recent severe weather outbreaks in the U.S., this study seeks to examine how individuals learn about and prepare for potential disasters in their area. Prior research has found that knowledge sufficiency and risk perception are two key factors that influence disaster preparedness. We examine the role of mediated and non-mediated sources in predicting information-seeking behaviors and disaster preparedness activities, as well as what influence the recent weather events may have on those issues. Findings indicated that worry and perceived risk about severe weather were significantly influential on information seeking, but that mediated and non-mediated sources, along with information sufficiency were key predictors of disaster preparedness. The findings are important for both scholars and practitioners of media messaging.