Miracle-dz/UniFAR-FTUs huggingface dataset:
Significance of BRAF and Nrf2 in evaluation of serous ovarian tumors

Background Ovarian carcinoma is the second leading cause of cancer-related deaths among women. Many treatment strategies have been developed; however, the prognosis is still poor. This study aims to evaluate the immunohistochemical expression of the serine/threonine-protein kinase B-raf (BRAF) and nuclear factor erythroid 2-related factor 2 (Nrf2) in serous ovarian tumors and to correlate their expression with clinicopathological features of the cases. Materials and methods This uncontrolled retrospective study was performed on 50 cases: benign (n=10), borderline (n=12), and malignant serous ovarian neoplasm (n=28). The malignant serous tumors included nine low-grade cases and 19 high-grade cases. The immunohistochemical expression of Nrf2 and BRAF was correlated with clinicopathological features of prognostic importance. Results The mean of BRAF expression is increased in borderline but it is almost equal for low-grade and high-grade carcinoma cases, which was statistically significant (P<0.05). Nrf2 was significantly expressed in the studied borderline and malignant tumors when compared with benign tumors (P<0.01). The mean of Nrf2 expression is increased from benign to borderline to ovarian carcinoma (low grade and high grade). This was highly statistically significant (P<0.01). A significant association was found between Nrf2 and BRAF expression and between each of them and mean age and laterality of the studied cases (P<0.01). A significant association was found between Nrf2 expression and peritoneal metastasis of the cases (P<0.05). A nonsignificant association was found between either of BRAF or Nrf2 and lymphovascular invasion, lymph node metastasis, distant metastasis, and TNM stage. Conclusion BRAF and Nrf2 could play a significant role in the step of carcinogenesis and then in progression of serous ovarian tumors.
Effect of supplementation of vitamin D and calcium on patients suffering from chronic non-specific musculoskeletal pain: A pre-post study

Background and Objective: Despite abundant sunshine, India is a country with high prevalence of vitamin D deficiency. It has been suggested that vitamin D deficiency could be a potential cause of chronic non-specific musculoskeletal pain. The study was conducted to evaluate the effect of supplementation of vitamin D and calcium on patients suffering with chronic non-specific musculoskeletal pain. Methodology: The experimental trial was a pre-post study conducted on 50 hypovitaminosis D patients aged 30–60 years visiting a local orthopedician or physician with complain of chronic non-specific musculoskeletal pain. Oral supplementation with vitamin D and calcium was given for 3 months. Before the intervention trial, pain, physical activity, serum vitamin D, serum calcium, body mass index and waist to hip ratio (WHR) of the respondents were assessed, which was statistically compared with post-intervention data of the same parameters. Assessment of pain was carried out using visual analog scale. Physical activity levels were compared pre and post the intervention. Also, fatigue, mood alteration, and sleep were compared. Results: Ninety percent of the subjects had vitamin D deficiency. Thirty-six percent of the subjects had severe chronic non-specific musculoskeletal pain, whereas 56% had moderate chronic non-specific musculoskeletal pain. The mean pain score prior to intervention was 6.22 which significantly decreased to 3.52. Mean vitamin D levels significantly rose from 17.38 ng/ml to 39.40 ng/ml. Serum vitamin D, serum calcium, and physical activity levels increased, whereas pain, weight, BMI, and WHR decreased significantly post-intervention. Conclusions: Supplementation with vitamin D and calcium decreases chronic non-specific musculoskeletal pain.
Possible COVID-19 reinfection case in Duhok City, Kurdistan: A case report

Since the discovery of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus disease (COVID-19) pandemic has become the most important health-care crisis globally, having spread to millions of people worldwide. Patients who recover from COVID-19 are still susceptible to reinfection. In this report, we present the case of a patient who had recovered from COVID-19. Recovery was defined as the resolution of symptoms accompanied by two consecutive SARS-CoV-2-negative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test results. Two months after the first infection, the patient tested positive for anti-SARS-CoV-2 antibodies. Three months after this test, the patient presented with mild COVID-19 symptoms that was confirmed by RT-PCR. These findings indicate a possible reinfection case. If the occurrence of reinfections is demonstrated to be true, then it may change the strategy of community-based disease prevention. More research is needed to confirm the concept of reinfection.
Assessing Media Bias in Cross-Linguistic and Cross-National Populations

Media bias is a worldwide concern. Although automated methods exist for the analysis of various forms of media bias, language is still an important barrier toward spotting worldwide differences in reporting. In this paper, we propose a methodology based on word embeddings, lexicon translation, and document similarity to assess media bias in news articles published in different idioms. We model media bias under the perspective of subjective language use, i.e., the more subjective the content of a news article is, the more biased it is. Our core assumption is that news articles reporting the same events, but written in different languages, should have similar levels of subjectivity; otherwise, we may have spotted biased text. Our method consists of using translated versions of subjectivity lexicons that were originally constructed for measuring subjectivity in the Brazilian Portuguese language. We evaluate our approach on two labeled data sets to show that our method is valid and apply our methodology to analyze recent and largely resounded topics, such as the Venezuela crisis and Syrian war, on four distinct idioms: Portuguese, German, English, and Spanish.
The enhancement of nitrification by indirect aeration and kinetic control in a submerged biofilm reactor

A submerged biological fixed-film reactor packed with plastic corrugated plates was employed to treat a wastewater of 100-400 mg NH4+-N/l and 80-130 mg COD/l. Nitrification and COD removal occurred in the reactor simultaneously. The kinetics of ammonium inhibition was studied, and used to control the bioreactor with the optimum condition. This operation strategy of kinetic control was able to reduce the duration of the acclimation of nitrifying bacteria in the reactor, and to enhance the removal of ammonium up to 95-98 %. The flow mode of indirect aeration in the reactor was able to maintain the suspended solid in the effluent below 4 mg/l without biofilm sloughing-off throughout the 300 operation days. In addition, the kinetic control and indirect aeration strategy of operation were able to obtain stable and low concentrations of COD, ammonium and nitrite in the effluent, and a high biomass of 14 g VSS/l in the reactor, when the influent loading of ammonium was up to 0.74 kg NH4+-N/m3-day associated with the medium surface loading of 10.4 g NH4+-N/m2-day.
Effects of Microbial Fe(III) Reduction on the Sorption of Cs and Sr on Biotite and Chlorite

ABSTRACT Microbially mediated reduction of Fe(III) in chlorite and biotite by Shewanella oneidensis MR-1 leads to a significant reduction in sorption of both Cs and Sr compared to the abiotic systems. As seen in previous studies, biotite is a more efficient sorbent than chlorite. Reduction of the mineral-associated Fe(III) causes increased dissolution of both minerals and reduces the sites available for Cs and Sr sorption. As this dissolution progresses it causes desorption of Cs and Sr from chlorite, but not biotite. Subsequent exposure to air increases sorption due to precipitation of secondary Fe(III) oxyhydroxide minerals derived from the Fe(II) released by bio-reduction. In contrast to successful bioremediation of redox active elements, this study suggests that microbial Fe(III) reduction could enhance the migration of Cs and Sr through phyllosilicate-dominated strata.
Feto-Maternal Outcomes In Patients With Jaundice In Pregnancy- Experience of a Tertiary Care Center

Pregnancy-a physiological state is often complicated by various pathologies and jaundice is one those, which carries a grave prognosis for both mother and fetus. Course of the disease is rapid and in a short period can affect the mother and the fetus (in utero) . So early diagnosis and prompt and active multidisciplinary management is required in these cases. This was a retrospective observational study carried out at a tertiary care hospital of north India during a period of 1 year in which all pregnant females presenting with jaundice in the 3 rd trimester of the age group of 18-35 years were included. A predesigned Performa was made in which data was entered retrospectively. Maternal outcomes and complications were recorded which included hepatic encephalopathy, DIC, APH, PPH and death whereas fetal outcomes in the form of prematurity, LBW, IUGR, APGAR scores, need for NICU admission were considered.Out of the total 22,500 deliveries, 150 (0.66%) were admitted with jaundice. Viral hepatitis remained the most common cause of jaundice followed by ecclapsia/ pre-ecclapsia. IHCP was the third most common cause of jaundice.Early diagnosis and prompt treatment of jaundice in pregnancy is the key to improvement of both maternal and fetal outcomes. © 2018 Elixir All rights reserved. Elixir Gynaecology 120 (2018) 51347-51349 Gynaecology Available online at www.elixirpublishers. com (Elixir International Journal) Gulshan Bano et al./ Elixir Gynaecology 120 (2018) 51347-51349 51348 Out of the total 150 females, 63 (42%) were primigravida whereas 87 (58%) were multigravida women. Viral hepatitis remained the most common type of jaundice followed by eclampsia/ pre-eclampsia. The causes of jaundice in the pregnant females are depicted below in Table 1:
VLSI architecture of a low-complexity Wiener Filter for video coding

The aim of presented thesis work is to provide a special purpose hardware implementation of AOMedia AV1 Wiener Filter. The basic idea was to start from the analisys of the complete AV1 codec and then focus on a very specific part based on the profiling results of the codec, in order to understand the percentage of use for each function and evaluate which one needed of more attention. The work presented here concerns the design, the implementation, the analysis and a possible optimization of an Hardware architecture for the Wiener Filter of AV1. The reasons why the attention was focused on the Wiener filter are multiple: first of all, the lack of informations about this kind of process in literature. Moreover, the importance of the in-loop filters in AV1 codec mechanism of improving the quality of the output images and, finally, the considerations about its usage in the coding process that will be better explained in thesis development. The first attempt to implement the architecture was to try to start from the source C code (available on AOMedia Website using GitHub) and build an equivalent model based on matrix calculus. This approach has been left because of many drawbacks related to the size of involved data that will be explained during the following chapters. So the choice was to follow completely the C code to maintain consistency : the basic implementation derives from an algorithm to architecture mapping in terms of data, operations, flow and parallelism. The basic idea of the presented work is not only to show the steps and the design choices to obtain a working VLSI implementation starting from some binding inputs, but also how it is possible to improve it based on the application to develop. So, once obtained a working architecture, it has been synthesized with Synopsys to evaluate the critical points and understand the direction to follow to improve that performances. Due to the huge dimension of many internal component of the filter and the very high parallelism, the complexity has been evaluated like one of the most critical parameter to optimize. Starting from the basic implementation and by using deeply a folding approach on the bigger component inside the architecture, a low-complexity version has been implemented, obtaining an area reduction of about 90%.
NBER WORKING PAPER SERIES ADVERSE SELECTION IN MEDICAID: EVIDENCE FROM DISCONTINUOUS PROGRAM RULES

The authors are grateful for assistance with data and project management from Erica Solway, Erin Beathard, Sarah Clark, and Lisa Cohn at the University of Michigan. We are also grateful to Michigan’s Department of Health and Human Services for help with technical aspects of the program and support for the evaluation. Finally, we acknowledge valuable suggestions on our analysis from Jeffrey McCullough, Robert Lieberthal, Paul Jacobs, Tom Seldon and other participants in seminars at the Chicago Health Economics Workshop, American Society of Health Economists, and the Agency for Healthcare Research and Quality. The University of Michigan Institute for Healthcare Policy and Innovation (IHPI) is conducting the evaluation required by the Centers for Medicare and Medicaid Services (CMS) of the Healthy Michigan Plan (HMP) under contract with the Michigan Department of Health and Human Services (MDHHS). Data collected for this paper was funded by MDHHS and CMS for the purposes of the evaluation but does not represent the official views of either agency. DHHS had the right to review the paper for consistency with reports prepared by the authors under terms of the contract. The views expressed herein are those of the authors and do not necessarily reflect the views of the National Bureau of Economic Research.
Meta-Analysis of Diagnostic Accuracy of M-CHAT by Categorical Rank of Clinical Diagnosis

s; ProQuest: dissertations and thesis at GSU, ProQuest central, arts and humanities, New Zealand, biological science, consumer health database, continental Europe, east Europe, central Europe, education database, health and medical collection, India, Latin American, Iberian, middle east and African, nursing and allied health, public health database, publicly available science, social science, UK and Ireland, ProQuest dissertation and thesis, social science premium, and education. All articles starting from April 2001 were reviewed for relevance in all countries, in English. The ancestral search included a traditional bibliography search of articles ultimately deemed to fit inclusion criteria. A prospective search was also performed on all articles deemed to fit inclusion criteria via identifying relevant articles using the “cited by” feature of Google Scholar. The following describes the process for data abstraction of the initial, ancestral and prospective searches. After collecting the titles and abstracts in the three searches the collected studies underwent a title/abstract review for M-CHAT screening studies. Studies were screened green to be included, yellow to be reviewed a second time and red to be screened out. To check on this initial screen-out process, 26 titles and abstracts were randomly selected and coded by an independent reviewer good agreement was found (K = 0.77). The process then follow that pdfs from yellow and green highlighted studies had a full text review performed for the inclusion/exclusion criteria, the studies were organized in keep remove computer files for quality control.
MxTasks: How to Make Efﬁcient Concurrency Control and Prefetching Easy

The hardware environment has changed rapidly in recent years: Many cores, multiple sockets, and large amounts of main memory have become a commodity. To beneﬁt from these highly parallel systems, the software has to be adapted. Sophisticated latch-free data structures and algorithms are often meant to address the situation. But they are cumbersome to develop and may still not provide the desired scalability. As a remedy, we present MxTasking , a task-based framework that assists the design of latch-free and parallel data structures. MxTasking also eases the information exchange between applications and the operating system, resulting in novel opportunities to manage resources in a truly hardware-and application-conscious way. As such, MxTasking also forms the basis for our vision of a truly co-designed system of operating system and database management system
On the twist-bend nematic phase formed directly from the isotropic phase

Abstract The intriguing twist-bend nematic (NTB) phase is formed, primarily, by liquid crystal dimers having odd spacers. Typically, the phase is preceded by a nematic (N) phase via a weak first-order transition. Our aim is to obtain dimers where the NTB phase is formed directly from the isotropic (I) phase via a strong first-order phase transition. The analogy between such behaviour and that of the smectic A (SmA)–N–I sequence suggests that this new dimer will require a short spacer. This expectation is consistent with the prediction of a molecular field theory, since the decrease in the spacer length results in an increase in the molecular curvature. A vector of odd dimers based on benzoyloxybenzylidene mesogenic groups with terminal ethoxy groups has been synthesised with spacers composed of odd numbers of methylene groups. Spacers having 5, 7, 9 and 11 methylene groups are found to possess the conventional phase sequence NTB–N–I; surprisingly, for the propane spacer, the NTB phase is formed directly from the I phase. The properties of these dimers have been studied with care to ensure that the identification of the NTB phase is reliable. Graphical Abstract
Organometric, structural and substructural changes in spleen in terms of experimental colon adenocarcinonoma development

Cancer immunology still has many paradoxical questions. One is of the role of the spleen in oncogenesis as well as its own structural reorganization effect on antitumor immunity. Literary data is contradictory and often radically opposite. Therefore, we conducted organometric studies and found out that at the time of pathohistological confirmation of adenocarcinoma in situ in the colon the spleen significantly decreases in size and loses weight. Histologically, deep destructive and degenerative changes in all components of the organ were found: fibrosis, degeneration and destruction of lymphoid tissue, focal zones of destruction in the red pulp. Submicroscopic analysis revealed the presence of lymphocytes with signs of apoptosis in the mantle and periarterial zones. In the white pulp, changes in part of the plasmatic cells were observed: a decrease in the size of the nuclei, damaged GER tubules and mitochondrial cristae. The severity of structural disorders of the spleen increases in the dynamics of the neoplastic lesion
Effects of laser therapy versus laser acupuncture on rheumatoid arthritis elderly patients

Objective Rheumatoid arthritis (RA) is regarded as the commonest and one of most known inflammatory arthritis. Our study was to determine the effects of laser therapy and laser acupuncture therapy on RA elderly patients. Subjects and Methods Forty patients with age of 65 to 75 years were being randomly allocated to 2 groups. Group(A) included twenty participants having RA treated via low level laser therapy. Group(B) included twenty participants having RA treated via laser acupuncture. All the patients underwent treatment by methotrexate. Treatments were provided three times each week to the two groups for twelve weeks.Independent laboratory technician and statistician were blinded to the study groups. Results There was significant reduction in scores of RAQoL questionnaire pre as well as post treatments for both the groups, with p<0.05. For HAQ questionnaire, significant difference was in the group treated with laser acupuncture. The IL-6 inflammatory marker had a significant reduction in pre as well as post treatments in only the group treated with laser European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 08, Issue 03, 2021 2718 acupuncture, with p < 0.05. In the MDA marker, it had a significant reduction in both groups for pre as well as post treatments. There was also a significant increase to the ATP antioxidant marker in pre as well as post treatments for both the groups, p<0.05. Conclusions This study suggested that the laser acupuncture can offer promising therapeutic benefits to assess in rheumatoid arthritis treatments; those therapeutic effects might be from inflammation reduction and oxidation stress alleviation, in addition to improvements in the antioxidants and energy status for RA patients.
ER-03-2020-0141_proof 524..554

Purpose – This paper contributes to the theory of the relationship between human resource management (HRM) and innovation at smallto medium-sized enterprises (SMEs) by conducting a conceptual analysis of the question why Germany boasts by far the highest number of “Hidden Champion” SMEs. This is done by case studies from the army and public financial management of aid disbursal in developing countries. Implications for HRM at SMEs are discussed. Design/methodology/approach – Conceptual analysis using case studies. Findings – Contributing towards filling the gap concerning theoretical underpinnings of the link between HRM and innovation, we suggest that interdisciplinary work from relevant organisational case studies indicates that the concept of institutional design to provide motivational incentives may be relevant, especially concerning high performance systems with bundles of HRM practices. Specifically, the fundamental principle of subsidiarity is found to be important. Research limitations/implications –The research is broadly applicable to organisations of all kinds, as the diverse case studies indicate. We point towards tentative implications for the firms that account for the majority of the work force, namely SMEs, and among them the most successful ones, the so-called “Hidden Champions”. Practical implications – HR managers can improve motivation, performance and innovation by decentralising decision-making as far as possible, while ensuring the overall organisational goals are well understood and shared, and resources are dedicated to train and educate staff. Additionally, the conception of rank-order competitions complements the institutional design. Social implications – Greater productivity and material performance as well as greater job satisfaction via larger autonomy and decision-making power on the local level can be achieved by the application of subsidiarity as key HRM configuration. This can be employed at SMEs, as discussed, but also other organisations. Further, the principle of subsidiarity and the greater emphasis on staff training and education may help reduce inequality. ER 43,2