Miracle-dz/UniFAR-FTUs huggingface dataset:
Major severe acute respiratory coronavirus-2 (SARS-CoV-2) vaccine-associated adverse effects; benefits outweigh the risks

ABSTRACT Introduction Since its emergence, there have been huge efforts to design vaccines against coronavirus disease 2019 (COVID-19) to inhibit its interpersonal spread. Global vaccine development is the most promising cost-effective method for overcoming the epidemic. However, following reports of post-vaccination thromboembolic adverse effects, there have been raising concerns about the safety profile of the COVID-19 vaccine. Areas covered We aimed to review the recent Food and Drug Administration (FDA)-approved vaccines and identify the organ-based major complications of COVID-19 vaccines based on reliable published studies. To find high-quality and large-scale observational, clinical trial, and cohort studies, PubMED, Scholar, Embase, and Web of Science were searched using keywords: COVID-19, SARS-CoV-2, vaccine, Pfizer (BNT162b2), Johnson and Johnson (Ad26.COV2), Moderna (mRNA-1273), Oxford AstraZeneca (ChAdOx1nCoV19), Coronavac (Sinovac), BBIBP-CorV (Sinopharm), adverse effect, and complication. To include all relevant articles, backward searching was also done on similar article citations. Case reports, studies including less than 10 participants, and biased articles were excluded. Expert opinion Based on data from high-quality and population-based studies, major adverse effects are divided into four major organ-specific groups, including cardiovascular, neurologic, hematologic, and immune-allergic side effects. The incidence of most of these side effects is not different between vaccinated and normal populations, and currently, the benefits of vaccination against COVID-19 are greater than the mortality and morbidity risks of COVID-19 infection. However, further studies, specifically systematic review and meta-analysis, are still indicated to investigate further unknown side effects of these vaccines and the existence of causality between the vaccine and reported adverse events.
Cancer Fear, Emotion Regulation, and Emotional Distress in Patients With Newly Diagnosed Lung Cancer

Background Research related to newly diagnosed lung cancer patients’ emotional regulation strategies and how these strategies influence their emotional distress is scarce. Objective The aim of this study was to investigate the relationship between cancer fear, emotion regulation, and emotional distress in patients with newly diagnosed lung cancer. Method A cross-sectional, correlation research design was conducted, using self-report questionnaires: the Cancer Fear Scale, the Emotion Regulation Questionnaire, and the Hospital Anxiety and Depression Scale. A total of 117 newly diagnosed lung cancer patients were sampled. Results Nearly 70% of newly diagnosed lung cancer patients had a high level of cancer fear; 56.4%, depression; and 45.3%, anxiety. Depression was positively associated with cancer fear (r = 0.239, P < .01) and expressive suppression (r = 0.185, P < .05), but negatively associated with cognitive reappraisal (r = −0.323, P < .01). Anxiety was positively associated with cancer fear (r = 0.488, P < .01) but negatively associated with cognitive reappraisal (r = −0.214, P < .05). Cancer fear and cognitive reappraisal were significant explanatory factors and explained 25.2% of variance in anxiety. Cancer fear, expressive suppression, and cognitive reappraisal were significant explanatory factors and explained 16.7% of variance in depression. Conclusions Newly diagnosed lung cancer patients with cancer fear and who used fewer cognitive reappraisal strategies or more expressive suppression had more emotional distress. Implications for Practice Clinicians should be attentive to patients’ cancer fears and emotion regulation strategies as early as possible to prevent their emotional distress.
Association between adherence to plant-based dietary patterns and obesity risk: a systematic review of prospective cohort studies.

The worldwide prevalence of obesity and its co-morbidities is staggering, and elevated body mass index represents a leading risk factor of death globally. Consistent evidence demonstrates a high-quality plant-based diet as an effective intervention for weight management, although it may be particularly challenging to adopt in its entirety for habitual meat consumers or individuals with especially poor-quality diets. Plant-based diets are increasingly studied using indices such as the overall plant-based diet index (PDI), healthful PDI, and unhealthful PDI, which offer more flexibility than a binary classification of vegetarianism and better facilitate translation into dietary recommendations. We summarized these recently accumulated studies to comprehensively evaluate plant-based diets in relation to obesity risk. We searched Medline, Embase, and CINAHL databases through January 2022 and identified 9 prospective adult cohorts. Reporting of results was consistent with PRISMA guidelines and certainty of the evidence was assessed using domains from GRADE. The PDI had a protective association with body weight gain and adiposity. Emphasis of healthful plant foods strengthened this association and emphasis of unhealthful plant foods demonstrated either a positive or null association. The certainty of the evidence was considered moderate. These findings have wide application to inform dietary interventions and sustainable policy recommendations. Prospero ID: CRD42020198143.
Retrospective analysis of methylprednisolone treatment alone and in combination with methotrexate in patients with extensive alopecia areata

Alopecia areata (AA) is a chronic autoimmune disorder that primarily affects the hair follicle. Systemic corticosteroids and methotrexate (MTX) are among the therapeutic options in severe cases. This study aimed to show whether the combination therapy of methylprednisolone (MP) and MTX was superior to MP alone in the management of extensive AA. A total of 26 patients with extensive AA, 14 treated with MP alone and 12 treated with the combination of MP and MTX, were retrospectively evaluated in terms of gender, age, severity of disease, clinical characteristics, disease duration, dose and duration of medications, therapy response, and side effects. Of the 26 patients with extensive AA, 14 were male and 12 were female, and the average age was 17.02 ± 10.70 years. All patients had more than 50% hair loss, 23 had extensive multifocal AA, and three had alopecia totalis. A total of 14 patients were treated with MP alone (starting dose: 0.3–0.5 mg/kg, maximum 32 mg/day), and 12 were treated with MP + MTX (starting dose: 5–15 mg/week, maximum 20 mg/week). A total of 12 of the 14 patients (85.7%) who were treated with MP alone showed a complete response, with the response rate of the patients who showed more than 50% response being 92.85%. Seven of the 12 patients (58.3%) who were treated with MP + MTX achieved complete healing, and all patients on this regimen had more than 50% treatment response. Our results showed that the combination therapy of MP and MTX was not superior to MP alone in the management of extensive alopecia areata.
Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T‐wave parameters

The T wave of the electrocardiogram (ECG) reflects ventricular repolarization. Repolarization heterogeneity is associated with reentrant arrhythmias. Several T‐wave markers (including QT interval) have been associated with ventricular arrhythmias, but studies linking such markers to underlying local repolarization time (RT) inhomogeneities are lacking. We aimed to investigate the relation of several T‐wave markers to controlled drug‐induced regional RT gradients in intact pig hearts.
Enhanced shift current bulk photovoltaic effect in ferroelectric Rashba semiconductor α-GeTe: ab initio study from three- to two-dimensional van der Waals layered structures

The ferroelectric Rashba semiconductors (FERSCs) are endowed with a unique combination of ferroelectricity and the spin degree of freedom, resulting in a long carrier lifetime and impressive bulk photovoltaic (BPV) efficiency that reached 25% in organometal halide perovskites. The BPV efficiency can be further improved by using low-dimensional ferroelectrics however, it is inhibited by the ferroelectric instability in low-dimensional perovskites and toxicity along with phase instability of the lead-halide perovskites. To address these challenges, the α-GeTe could be of great importance which is the simplest known lead-free FERSC with an intrinsic layered structure. Therefore, in this work, we investigate the BPV properties of three- to two-dimensional van der Waals structures of α-GeTe by calculating the shift current (SHC). We predict that the mono (1.56 Å) and bi-layers (5.44–6.14 Å) α-GeTe with the buckled honeycomb structure are dynamically stable and possess the characteristic features of the bulk up to the nanoscale limit. The SHC of ∼70 μA V−2 is calculated in bulk α-GeTe which is 20 times larger than that obtained in organometal halides in the visible light. The SHC increases with decreasing the number of layers, reaching a maximum amplitude of ∼300 μA V−2 at 2.67 eV in the monolayer which is more than double that obtained in monolayer GeS. We find that the SHC in monolayer α-GeTe can be further enhanced and redshifted by applying a compressive strain; which is correlated with the strong absorption of the xx-polarized light, stimulated by the more delocalized p x /y orbital character of the density of states. Furthermore, in the bilayer structures, the magnitude of the SHC is sensitive to the layers’ stacking arrangement and a maximum SHC (∼250 μA V−2) can be achieved with an AB-type stacking arrangement. Combining these results with the benefits of being environmental-friendly material makes α-GeTe a good candidate for next-generation solar cells application.
CREATE Childhood Cancer Rehabilitation Program development: Increase access through interprofessional collaboration

Cancer and its treatment can lead to functional limitations affecting ongoing development in children and adolescents. We developed a pediatric cancer rehabilitation program that integrates evidence‐based rehabilitative care into cancer treatment. The program utilizes the CREATE (collaboration, rehabilitation/research, education, assessment, treatment, evaluation) Childhood Cancer Rehabilitation model. We aim to describe the structural and process components of our rehabilitation program and provide an access and utilization analysis.
On Nominative-Genitive Conversion *

Nominative-Genitive Conversion (hereafter NGC) in Japanese, which is also often called Ga/No Conversion, is one of the most intriguing syntactic phenomena in the history of generative grammatical study of Japanese (see Harada 1971, 1976, Bedell 1972, Inoue 1976, Shibatani 1977, 1978, Nakai 1980, Saito 1982, Fukui 1986, Fukui and Nishigauchi 1992, Terada 1990, Murasugi 1991, Miyagawa 1989, 1993, Ura 1993, Sakai 1994, Hasegawa 1995, Watanabe 1994, 1996a, 1996b, and Ochi 1999, among many others). Nevertheless, as we will see below, the phenomenon has not yet been provided with a conceptually and empirically adequate theoretical account. The purpose of this paper is to elucidate the syntactic architecture of NGC and to explore an optimal account for the phenomenon within the framework of the Minimalist Program (cf. Chomsky 1995, 1999, 2000). In particular we will reject on much empirical grounds the ECM/Raising analysis of NGC, which assumes the genitive Case feature-checking by an external D head. Our investigation reveals that UG allows another mechanism of genitive Case checking in addition to D. More specifically, it will be argued that the genitive Case can be checked by the φfeature of the C-T-V amalgamate formed via AGREE, independently of D. It is shown that this hypothesis in fact has a number of important consequences for parametric syntax.
Fast algorithms for L INFINITY problems in multiview geometry.

Removable partition systems of the type embodying top and bottom tracks enclosing a plurality of channel shaped vertical studs and vertical wall panels secured to the studs by means of hooks extending from the inner surface of the panel to engage notches defined in the studs. The improvement consists in a hook strip secured to the inner face of the wall panel and including a hardened planar surface and a downwardly extending hook. The hook includes inclined top and bottom edges, a horizontal bight and an inwardly protruding camming surface. The horizontal bight rests upon the bottom of the notch, while the camming surface tension fits the inner surface of the stud so as to securely mount the wall panel with respect to the stud.
Competitive intelligence and competitiveness in accommodation businesses: the role of employee training effectiveness

ABSTRACT This study aims to investigate the mediating role of employee training effectiveness on the relationship between competitive intelligence and competitiveness. Using a sample consisting of 651 employees working in accommodation enterprises in Nevsehir, Turkey, the relationships between the variables were tested using the two-stage structural equation model analysis. The mediating effects were examined through the bootstrap method. The research findings support the proposed model to a large extent, indicating that both competitive intelligence and employee training effectiveness significantly affect competitiveness. Competitive intelligence positively influences employee training effectiveness. In addition, employee training effectiveness partially mediates the relationship between competitive intelligence and competitiveness. Based on the results, theoretical and managerial implications are provided along with the limitations and suggestions for future research.
COMMON FIXED POINT AND BEST APPROXIMATION FOR BANACH OPERATOR PAIRS IN NON-STARSHAPED DOMAIN

Common fixed point results for Banach operator pair with generalized nonexpansive mappings in non-starshaped domain of metric space have been obtained in the present work. As application, more general best approximation results in normed space have also been determined. These results extend and generalize various existing known results with the aid of Banach operator pair and without starshaped condition of domain. 2000 AMS Classification. 41A50, 47H10, 54H25.
Regulation of Macrophage IFNγ-Stimulated Gene Expression by the Transcriptional Coregulator CITED1

Macrophages are highly dynamic innate immune cells that adopt temporary phenotypes, known as polarization states, in response to changing environmental signals to combat microbial infection and contribute to the maintenance of tissue homeostasis. During the early stages of an infection, exposure to interferon-gamma (IFNγ) and microbial ligands induce M1 polarization, a heightened proinflammatory anti-microbial state, by regulating the expression of interferon stimulated genes (ISGs). While this response must be sufficiently vigorous to ensure the successful clearance of invading pathogens, it must also be spatially and temporally restricted to prevent uncontrolled inflammation that could result in tissue damage and disease. This is controlled by a variety of cell-extrinsic and -intrinsic mechanisms, including the expression of CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2), a transcriptional coregulator that limits IFNγ-stimulated proinflammatory gene expression by inhibiting STAT1- and IRF1-regulated ISGs. In this study, we show that CITED1, another member of the CITED family of proteins, is itself an ISG and is expressed in a STAT1-dependent manner, and that IFNγ stimulates the nuclear accumulation of fluorescently tagged CITED1 proteins. In contrast to CITED2, ectopic expression of CITED1 enhanced the expression of a subset of ISGs, including Ccl2, Ifit3b, Isg15, and Oas2. This effect was reversed in a Cited1 null cell line produced by CRISPR-based genomic editing. Collectively, these data show that CITED1 helps to maintain proinflammatory gene expression during periods of prolonged IFNγ exposure and suggests a distinct and antagonistic relationship between CITED proteins in the regulation of macrophage inflammatory function.
Red blood cell lingering modulates hematocrit distribution in the microcirculation

The distribution of red blood cells (RBCs) in the microcirculation determines the oxygen delivery and solute transport to tissues. This process relies on the partitioning of RBCs at successive bifurcations throughout the microvascular network and it is known since the last century that RBCs partition disproportionately to the fractional blood flow rate, therefore leading to heterogeneity of the hematocrit (i.e. volume fraction of RBCs in blood) in microvessels. Usually, downstream of a microvascular bifurcation, the vessel branch with a higher fraction of blood flow receives an even higher fraction of RBC flux. However, both temporal and time-average deviations from this phaseseparation law have been observed in recent works. Here, we quantify how the microscopic behavior of RBCs lingering (i.e. RBCs temporarily residing near the bifurcation apex with diminished velocity) influences their partitioning, through combined in vivo experiments and in silico simulations. We developed an approach to quantify the cell lingering at highly-confined capillary-level bifurcations and demonstrate that it correlates with deviations of the phase-separation process from established empirical predictions by Pries et al. Furthermore, we shed light on how the bifurcation geometry and cell membrane rigidity can affect the lingering behavior of RBCs, e.g. rigid cells tend to linger less than softer ones. Taken together, RBC lingering is an important mechanism that should be considered when studying how abnormal RBC rigidity in diseases such as malaria and sickle-cell disease could hinder the microcirculatory blood flow or how the vascular networks are altered under pathological conditions (e.g. thrombosis, aneurysm).
Synchronicity of viral shedding in molossid bat maternity colonies

Infection dynamics in vertebrates are driven by biological and ecological processes. For bats, population structure and reproductive cycles have major effects on RNA virus transmission. On Reunion Island, previous studies have shown that parturition of pregnant females and aggregation of juvenile Reunion free-tailed bats (Mormopterus francoismoutoui) are associated to major increase in the prevalence of bats shedding viruses. The synchronicity of such shedding pulses, however, is yet to be assessed, between viruses but also maternity colonies. Based on 3422 fresh faeces collected every two to five weeks during four consecutive birthing seasons, we report the prevalence of bats shedding astroviruses (AstVs), coronaviruses (CoVs), and paramyxoviruses (PMVs) in two maternity colonies on Reunion Island. We found that the proportion of bats shedding viruses is highly influenced by sampling collection dates, and therefore by the seasonality of parturition. We highlight that virus shedding patterns are reproducible among years and colonies for CoVs and at a lesser extent for PMVs, but not for AstVs. We also report 1% of bats harbouring double infections, mostly CoVs and PMVs, but none shedding simultaneously AstVs, CoVs and PMVs.
Genome size variation and evolution during invasive range expansion in an introduced plant

Plants demonstrate some of the greatest variation in genome size among eukaryotes, and their genome sizes can vary dramatically across individuals and populations within species. This genetic variation can have consequences for traits and fitness, but few studies have been able to attribute genome size differentiation to ecological and evolutionary processes. Biological invasions present particularly useful natural laboratories to infer selective agents that might drive genome size shifts across environments and population histories. Here, we test hypotheses for the evolutionary causes of genome size variation across 14 invading populations of yellow starthistle, Centaurea solstitialis, in California, USA. We use a survey of genome sizes and trait variation to ask: (1) Is variation in genome size associated with developmental trait variation? (2) Are genome sizes smaller toward the leading edge of the expansion, consistent with selection for ‘colonizer’ traits? Or alternatively, does genome size increase toward the leading edge of the expansion, consistent with predicted consequences of founder effects and drift? (3) Finally, are genome sizes smaller at higher elevations, consistent with selection for shorter development times? We found that 2C DNA content varied 1.21-fold among all samples, and was associated with flowering time variation, such that plants with larger genomes reproduced later, with lower lifetime capitula production. Genome sizes increased toward the leading edge of the invasion, but tended to decrease at higher elevations, consistent with genetic drift during range expansion but potentially strong selection for smaller genomes and faster development time at higher elevations.
Sequential involvements of macaque perirhinal cortex and hippocampus in semantic-like memory including spatial component

The standard consolidation theory suggests the critical involvement of the hippocampus (HPC) in acquiring new knowledge, while the perirhinal cortex (PRC) is involved in its long-term storage (i.e., semantic memory). Converging studies have shown exclusive involvement of the PRC in item processing, while the HPC relates the item with a spatial context. These two lines of literature raise the following question; which brain region is involved in semantic recall that includes the spatial components? To solve this question, we applied an item-location associative (ILA) paradigm in a single-unit study using non-human primates. We trained two macaques to associate four visual item pairs with four locations on a background map before the recording sessions. In each trial, one visual item and the map image at a tilt (−90 to 90 degrees) were sequentially presented as the item-cue and the context-cue, respectively. The macaques chose the item-cue location relative to the context-cue by positioning their gaze. Neurons in both PRC and HPC but not area TE exhibited item-cue responses which signaled retrieval of item-location associative memory. This retrieval signal first appeared in the PRC before appearing in the HPC. We examined whether neural representations of the retrieved locations were related to the external space where the macaques viewed. A positive representation similarity was found in the HPC but not PRC, suggesting a contribution of the HPC to relate the retrieved location with a first-person perspective of the subjects. These results suggest their distinct but complementary contributions to semantic recall including spatial components.
Separate and shared low-dimensional neural architectures for error-based and reinforcement motor learning

Motor learning is supported by multiple systems adapted to processing different forms of sensory information (e.g., reward versus error feedback), and by higher-order systems supporting strategic processes. Yet, the extent to which these systems recruit shared versus separate neural pathways is poorly understood. To elucidate these pathways, we separately studied error-based (EL) and reinforcement-based (RL) motor learning in two functional MRI experiments in the same human subjects. We find that EL and RL occupy opposite ends of neural axis broadly separating cerebellar and striatal connectivity, respectively, with somatomotor cortex, and that alignment of this axis to each task is related to performance. Further, we identify a separate neural axis that is associated with strategy use during EL, and show that the expression of this same axis during RL predicts better performance. Together, these results offer a macroscale view of the common versus distinct neural architectures supporting different learning systems.