Miracle-dz/UniFAR-FTUs huggingface dataset:
Two new records of meso- and bathy-planktonic chaetognaths from the Indian seas

A brief description of the two meso- and bathy-planktonic species of Sagitta namely, S. macrocephala Fowler and S. prox. maxima (Conant) that are recorded for the first time from the Indian seas is given here. The affinities of S. prox. maxima with its congeners are discussed.
Assessment of burn-out among staff nurses working in a tertiary care health centre in North India

Background: This descriptive, cross sectional study identified the occurrence of burnout and some associated factors among nurses working in various departments at Indira Gandhi Medical College, Shimla, Himachal Pradesh, India which is a tertiary care health centre in the state.Methods: A total of 257 nurses screened in the hospital out of which 81 completed the study. Eighty-one nurses answered a self-administered questionnaire (sociodemographic aspects, working conditions, and Maslach Burnout Inventory). Mean scores were compared using ANOVA test. Student T-test was applied to compare mean scores between the groups.Results: All the participants were females (100%), with up to five years’ experience. High levels of emotional stress (45.7%) and depersonalization (24.7%) were identified, as well as low professional fulfilment (6.2%), and 8.6% presented burnout. The following factors were associated: high levels of emotional stress and always perform tasks very quickly (p=0.04) and receiving a salary incompatible to the effort employed (p=0.03); high levels of depersonalization and with up to five years’ experience (p=0.02) and often perform tasks very quickly (p=0.008). For 19.0%, at least two of the three dimensions pointed to high propensity to the syndrome.Conclusions: Searching for personal solutions for work problems must draw our attention, since it discourages health and work performance. Professionals may feel more fulfilled and satisfied by adjusting their work expectations. However, on a long-term basis, persisting in stressful work conditions enhances emotional exhaustion, depersonalization and feelings of low fulfilment at work.
George

not much worried whether they be right or wrong. His desire to be the center of attraction may lead him to do things considered irrational when viewed from other angles. If he is in the upper 10 per cent of his class at school, it might be well to advance him to the next grade, provided he is sufficiently interested to show that he is capable of doing the work. If convenient, the teacher should somehow leave the impression with him that she is dependent on him for assistance in running the school. " George was turned over to me for clinical teaching in arithmetic with the idea of finding out what he could do, and, if possible, to
Chromosome Missegregation in Alzheimer's Disease Caused by Presenilin 1

Mutations in the presenilin 1 gene account for most early-onset familial Alzheimer’s disease (FAD). The presenilins and AD may also be related through a common involvement in the cell cycle. Here we report that one important aspect of the cell cycle—proper chromosome segregation—is dependent on presenilin function and therefore may be involved in AD pathogenesis. Specifically we find that FAD mutations in presenilin 1 (M146L and M146V) lead to chromosome missegregation and aneuploidy in vivo and in vitro: 1) Both metaphase chromosome analysis and in situ hybridization reveal significant aneuploidy in the lymphocytes and neurons of PS-1 transgenic mice. 2) Transiently transfected human cells expressing normal and, especially, mutant PS-1 develop aneuploidy within 48 hours, including trisomy 21, while cells transfected with dominant negative PS-1 genes lacking -secretase activity have no effect on chromosome segregation. 3) Analysis of mitotic spindles in the transfected cells reveals abnormal microtubule arrays and lagging chromosomes. The possible mechanisms by which cell cycle defects and chromosome
Immunohistochemical analyses in a case of high grade urothelial carcinoma featuring rare chordoid features

A 70-year-old Japanese man complained of macrohematuria. He was diagnosed with high grade urothelial carcinoma (UC), G3, and underwent transurethral resection of bladder tumor (TUR-BT) twice. UC containing a chordoid component was found in the TUR-BT tissue samples. Total cystectomy combined with nephroureterectomy was performed because of deep muscular invasion into the bladder, in addition to intensive ureteral and prostatic invasion. Histopathological findings from the bladder tumor revealed an invasive UC with an adenocarcinoma component, combined with peculiar chordoid features associated with abundant myxoid matrix. The chordoid component metastasized to the right kidney, invading the prostate and right ureter. Chordoid component was detected in approximately 50% in total tumor extent Immunohistochemical analysis indicated that, although the chordoid component showed similar staining results to those of chordoma (namely, it was positive for CAM5.2 and cytokeratin 19 and focally positive for epithelial membrane antigen, carcinoembryonic antigen, and S100 protein), the UC and chordoid components were both negative for vimentin. In contrast, both chordoma and extraskeletal myxoid chondrosarcoma demonstrate positivity for vimentin, which is histologically similar to the present case. The patient had come to see us, before 11 months. A follow-up assessment showed no recurrence or distant metastasis 8 months after twice TUR-BT and five months since total cystectomy. But unfortunately, the patient dropped out from our follow-up data, because he did not come to our hospital. Thus, pathologists and clinicians must consider that a chordoid component may represent the malignant characteristic of UC.
Community Studies Reporting Association between Self-Rated Health and Mortality

The following table amends and updates the summary table of mortality studies published in 1997 (Idler and Benyamini 1997). To locate additional studies, we searched Medline using the terms self-rated health, self-rating/s of health, self-assessment/s of health, self-assessed health, self-evaluated health, perception/s of health, perceived health, self-evaluation/s of health, subjective assessment/s of health, subjective health, selfreported health, and self-reports of health and crossed these terms with mortality, survival, and deaths. Additional studies not reporting these terms in their abstracts were identified through careful monitoring of the literature. Articles identified with this process were eliminated if they were not in English, if the study population was not a representative community sample, or if the estimate of the effect of self-rated health on mortality was not adjusted for a set of health status covariates. With these restrictions, we identified 19 additional studies for the period 1995 to 1998. The studies in Table 1 are presented chronologically. They report secondary analyses of large data sets, use increasingly sophisticated statistical methods, and adjust for comprehensive sets of health status covariates. The association of poor self-ratings of health with higher risk of mortality is consistent; in just 2 of the 19 studies there were no effects of self-rated health for either men or women. In most of its content, the table presented here is like the 1997 table. The data sources are international, 15 of the 19 have elderly samples, and the health status covariates almost always include activities of daily living
Determinants of Active Trachoma among Children aged 1-9 Years in Ol Donyo Nyokie Location, Kajiado County, Kenya

Objective: To determine the factors associated with active trachoma among children aged 1-9 years in Ol Donyo Nyokie, Kajiado County. Methods: This was a descriptive cross-sectional study which utilized both quantitative and qualitative techniques for data collection and was carried out at Ol Donyo Nyokie, Kajiado County. Sequential sampling procedure was used to select study participants. A total of 345 mothers together with their children were sampled. The random start was adopted using lottery method and then every 3rd household until a desired sample size of 345 had been achieved. In households with more than one child, one among them was selected by lottery method. Physical examination on the children’s eyes was done while their respective mothers participated in the questionnaire survey supported by observation checklist. Two Focus group discussions were also conducted among mothers and Key Informant interviews among healthcare providers. Results: The overall prevalence of active trachoma was found to be 15.7%. Stratified by age and sex, the younger age group (1-5) years had a 2.13-fold risk of getting active trachoma (χ 2 (1) =5.93, p 0.05). In the final logistic regression model; Face washing frequency (P 30 mins(P 10 % prevalence). Community participation in education and outreach services are also crucial. Keywords: Active trachoma, children 1-9 years, risk factors, control and prevention, Kenya. Afr J Health Sci . 2017; 30(2):77-86
Exercise prehabilitation program for patients under neoadjuvant treatment for rectal cancer: A pilot study

Context: Prehabilitation is emerging as a method of preparing patients physically and mentally for the often disabling effects of cancer treatment. Aims: This study aims to assess the feasibility and to explore the potential effects of a prehabilitation program consisting of educational physical exercise sessions in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy treatment (NCRT). Settings and Design: This was a pilot study with 12 patients (3 males and 9 females, age 61 ± 7 years). Subjects and Methods: The program included six educational sessions of exercise during NCRT. Adherence to the intervention; quality of life (QoL); anxiety and depression; body mass index; physical fitness (peak oxygen uptake (VO2peak), handgrip and dynamic leg strength); and physical activity (PA) levels were measured. Statistical Analysis Used: Data are reported as the mean ± standard deviation or medians and interquartile ranges for questionnaire-derived data. Secondary outcome measures were compared using the nonparametric Wilcoxon test. The threshold P value for significance was calculated after correction for multiple comparisons using the Bonferroni method. Results: Adherence to the program was 64 of 72 possible exercise education sessions completed, i.e., 89%. We detected a trend toward a significant improvement in VO2peak after the intervention (P = 0.015), together with reduced scores for both depression (P = 0.017) and the QoL domain “emotional function” (P = 0.027). Mean levels of moderate to vigorous PA tended to increase after the exercise program (P = 0.091). Conclusions: Exercise might be an effective prehabilitation strategy for surgery during the period of NCRT.
Immunophenotypic analysis of ovarian and testicular Müllerian papillary serous tumors.

Intratesticular Mullerian papillary serous tumors lacking stromal invasion are uncommon neoplasms whose immunophenotypic properties have not been studied extensively. We present such information here and compare it with information from a group of ovarian papillary serous tumors of low malignant potential ("borderline serous tumors") that are morphologically identical. We compared the histologic features of our index case of intratesticular Mullerian papillary serous tumor with those of nine ovarian papillary serous tumors. We then evaluated both the index case and the ovarian tumors with antibodies against carcinoembryonic antigen, LeuM1, CA125, estrogen receptors, progesterone receptors, cytokeratin 7, and cytokeratin 20, by use of established immunohistochemical techniques. The testicular and ovarian tumors were morphologically indistinguishable. The intratesticular Mullerian papillary serous tumor expressed LeuM1, CA125, estrogen receptors, progesterone receptors, cytokeratin 7, and weak cytokeratin 20; carcinoembryonic antigen was not expressed. All of the ovarian papillary serous tumors expressed CA125, estrogen receptors, and cytokeratin 7. Eight of nine expressed progesterone receptors. Five of nine stained with LeuM1. Two of nine were focally weakly positive with cytokeratin 20. LeuM1 expression helps distinguish testicular papillary serous tumors from mesothelial proliferations, which might seem morphologically similar. The immunophenotype of intratesticular and female genital papillary serous tumors is similar; this similarity extends to expression of estrogen and progesterone receptors, which is rare in neoplasms in men, especially among testicular neoplasms.
Public health risks of Escherichia coli and Staphylococcus aureus in raw bovine milk sold in informal markets in Egypt.

INTRODUCTION Milk is an important food in Egypt and most of it is sold as raw milk in informal markets. METHODOLOGY This study was conducted to investigate the public health risks of Escherichia coli and Staphylococcus aureus in milk sold in informal markets in Egypt. A total of 121 milk samples were analyzed for occurrence, virulence genes and antibiotic resistance of E. coli and S. aureus. RESULTS A total of 35/121 (28.9%) of milk samples were contaminated with 16/121 (13.2%) E. coli, 22/121 (18.2%) S. aureus, and 3/121 (2.5%) both isolates. Shiga-toxin producing E. coli (STEC), Enterotoxigenic E. coli (ETEC) and Enterotoxigenic S. aureus were detected in 5/121 (4.1%), 2/121 (1.7%) and 8/121 (6.6%) of the examined milk samples, respectively. Multiple drug resistances (MDRs) were showed by 14/16 (87.5%) and 21/22 (95.5%) of E. coli and S. aureus isolates, respectively. E. coli isolates showed high resistance for cephalothin (87.5%), ampicillin (68.8%) and tetracycline (68.8%), but were sensitive for gentamicin and chloramphenicol. Resistance phenotypes of E. coli were diverse; however, STEC isolates were significantly associated with co-resistance to cephalothin, ampicillin and tetracycline (P< 0.05). Two (9.1%) of S. aureus isolates were methicillin-resistant (MRSA) but sensitive to gentamicin (GS-MRSA). Five (22.7%) of S. aureus isolates were gentamicin-resistant methicillin-sensitive S. aureus (GR-MSSA). S. aureus isolates also showed high resistance for ampicillin (100%), tetracycline (90.1%) and sulfamethoxazole-trimethoprim (90.1%). CONCLUSION These findings highlighted the potential public health hazards of E. coli and S. aureus pathogens in raw milk sold in informal markets in Egypt.
Neurons in Primate Visual Cortex Alternate between Responses to Multiple Stimuli in Their Receptive Field

A fundamental question concerning representation of the visual world in our brain is how a cortical cell responds when presented with more than a single stimulus. We find supportive evidence that most cells presented with a pair of stimuli respond predominantly to one stimulus at a time, rather than a weighted average response. Traditionally, the firing rate is assumed to be a weighted average of the firing rates to the individual stimuli (response-averaging model) (Bundesen et al., 2005). Here, we also evaluate a probability-mixing model (Bundesen et al., 2005), where neurons temporally multiplex the responses to the individual stimuli. This provides a mechanism by which the representational identity of multiple stimuli in complex visual scenes can be maintained despite the large receptive fields in higher extrastriate visual cortex in primates. We compare the two models through analysis of data from single cells in the middle temporal visual area (MT) of rhesus monkeys when presented with two separate stimuli inside their receptive field with attention directed to one of the two stimuli or outside the receptive field. The spike trains were modeled by stochastic point processes, including memory effects of past spikes and attentional effects, and statistical model selection between the two models was performed by information theoretic measures as well as the predictive accuracy of the models. As an auxiliary measure, we also tested for uni- or multimodality in interspike interval distributions, and performed a correlation analysis of simultaneously recorded pairs of neurons, to evaluate population behavior.
An Evaluation of Provider-Sharing Networks of Patients Using Prescription Opioids

IMPORTANCE: Patients using prescription opioid are embedded in a network due provider-sharing and living in the same community. As a result, they may exert influence on each other’s treatment preferences and share attitudes towards prescription opioid use and misuse. OBJECTIVE: To determine patient characteristics associated with the observed pattern of shared prescribers in a network and identify influential patients in the network. DESIGN, SETTING, AND PARTICIPANTS: We conducted a cross-sectional network-based study using the Rhode Island (RI) Prescription Drug Monitoring Program (PDMP) data for the 2015 calendar year. All patients who filled at least one opioid prescription at a retail pharmacy were eligible. The analysis was limited to patients who were on a stable opioid regimen and used only one source of payment, and filled only one type of opioid medication (oxycodone, hydrocodone or buprenorphine/naloxone) from ≥ 3 prescribers, and visited ≥ 3 pharmacies during the year. To minimize the influence of less relevant network connections, we excluded institutional providers and providers who issued opioid prescriptions to ≤ 6 patients. We applied social network analysis (SNA) methods to a sample of 372 patients connected to each other through provider-sharing. We used the exponential random graph model (ERGM) assuming conditional dyadic independence to examine the relationship between patient attributes and the likelihood of forming network ties. Homophily was defined as the tendency of patients to associate with others who have similar characteristics. Three centrality measures (degree, closeness, and betweenness) were used to identify patients with potential influence in the opioid prescription network. MAIN OUTCMES AND MEASURES: We provide a visual and descriptive characterization of the network, used centrality measures to identify influential patients, and ERGM to assess homophily and differential homophily. RESULTS: The mean age of patients included in the analysis was 51 years; 53% were female; 57% took oxycodone, 34% took hydrocodone and 9% took buprenorphine/naloxone. On average, 53% of patients received less than 50 morphine milligram equivalents (MME) daily, and the mean (standard deviation [SD]) number of opioid prescriptions per patient was 14.4 (6.6). Sixty-four percent of patients had commercial insurance, 28% had Medicaid, 5% had Medicare, and almost 2.5% used cash payment only. All three centrality measures were in agreement on the identification of the most influential patient in the opioid prescription network but overall correlation between the measures was low. After controlling for the main effects in the ERGM model, homophily was associated with age group, method of payment, number and type of opioid prescription filled, mean daily MME, and number
THE EFFECT OF EDUCATIONAL SELF-MEDICATION FOR DYSMENORRHEA TREATMENT USING OVER THE COUNTER DRUGS

Self-medication is an attempt to treat the disease felt by using the over-the-counter drug (OTC) which is based on knowledge about the safe and rational treatment. The implementation of the self-medication drug use tends to be misused. The ease in self-medication treatment in community shows the importance of education in the use of medications safely and rationally. Education is carried out appropriately with effective methods and media. This research used quasi-experimental design approach with one group pretest – posttest design. The sample of this research was 34 female students from Frateran High School Malang selected using a purposive sampling. The data was analyzed using Paired T-Test. The results of comparison of self-medication treatment using OTC drugs before (pre) and after (post) education provided the significance value obtained 0.000 which is smaller than alpha 0.05. The null hypothesis (H 0 ) can be rejected and concluded that there is a different score in the self-medication treatment using OTC drugs before (pre) and after (post) education. It can be concluded that the education can affect the improvement of knowledge of the students for effectiveness of lowering OTC drugs abuse.
Impact of femoroacetabular impingement and dysplasia of the hip on hip joint sphericity

Background: This paper presents a parametric investigation into the effect of femoroacetabular impingement (FAI) and developmental dysplasia of the hip (DDH) on the sphericity of the femoral supra-equatorial region and acetabulum. Methods: Radiographic parameters from x-rays, sphericity calculations and visualisation and joint contact area and pressure from FE models of 10 DDH, FAI and normal hips were analysed and compared both within and between hip groups. Results: The sphericity of the acetabulum and femoral head of both the DDH and FAI groups was found to be less than that for normal hips but the variation in sphericity was greater (range 2.4% for normal hips, compared to 3.3% and 3.1% for the FAI and DDH groups respectively). For the DDH group, femoral head sphericity was found to correlate strongly with 2 of the radiographic parameters used to diagnose the condition, CE angle and Sharp angle. For FAI and DDH hips peak contact pressure primarily occurred in Ilizaliturri Zone 2 (anterior-superior region) in the acetabulum and femoral head which corresponded with increased aspherity in this region compared to the normal hip group. These findings correlate with loading and damage patterns reported in the literature. Additionally, our analysis identified a protrusion of bone in Ilizaliturri Zones 1 and 6 (anterior-inferior region) of the acetabulum of a subgroup of FAI hips, whose existence was confirmed using a full-scale hip model fabricated using a 3D printer, which we believe could result in cartilage damage. Conclusion: We postulate that such protrusions could potentially explain residual symptoms and unaddressed structural deformity in patients who have undergone FAI surgery.
Linseed oils with different fatty acid patterns in the diet of broiler chickens

The effect of 1, 3, 5 or 7% of linseed oil on the performance and content of nutrients in meat was studied in an experiment with broiler chickens from 25 to 40 days of age. Oils made either of seeds of the cultivar Atalante (A; groups A1; A3; A5; A7) with a high content of α-linolenic acid or of the cultivar Lola (L) with a pre - dominating content of linoleic acid (L1; L3; L5; L7) were used. The diets were formulated to maintain a constant energy/protein ratio. As compared with the groups receiving 1% and 3%, body weight gains were higher in the groups receiving 5% and 7% of oils in the feed mixture (P < 0.01). A lower feed consumption per unit of weight gain was also recorded in the groups with 7% and 5% of oils than in the groups receiving 1% and 3% (P < 0.01). The content of protein in breast meat in the group with 7% was lower than in the groups with 1% and 5% (P < 0.05). There were no differences in the contents of protein in thigh meat. Similarly, no differences were found out in the contents of fat in thigh and breast meat. In thigh meat, the values of ether extract were always significantly higher (P < 0.01) and those of protein content significantly lower (P < 0.01) than in breast meat. There were no significant differences in basic production parameters, breast and thigh meat percentages in body weight, and in the dry matter, ether extract and crude protein contents in meat between the groups receiving linseed oil with different levels of n-6 and n-3 polyunsaturated fatty acids.