Miracle-dz/UniFAR-FTUs huggingface dataset:
The VLT-FLAMES Tarantula Survey XXIV. Stellar properties of the O-type giants and supergiants in 30 Doradus

The Tarantula region in the Large Magellanic Cloud contains the richest population of spatially resolved massive O-type stars known so far. This unmatched sample offers an opportunity to test models describing their main-sequence evolution and mass-loss properties. Using ground-based optical spectroscopy obtained in the framework of the VLT-FLAMES Tarantula Survey (VFTS), we aim to determine stellar, photospheric and wind properties of 72 presumably single O-type giants, bright giants and supergiants and to confront them with predictions of stellar evolution and of line-driven mass-loss theories. We apply an automated method for quantitative spectroscopic analysis of O stars combining the non-LTE stellar atmosphere model {\sc fastwind} with the genetic fitting algorithm {\sc pikaia} to determine the following stellar properties: effective temperature, surface gravity, mass-loss rate, helium abundance, and projected rotational velocity. We present empirical effective temperature versus spectral subtype calibrations at LMC-metallicity for giants and supergiants. In the spectroscopic and classical Hertzsprung-Russell diagrams, our sample O stars are found to occupy the region predicted to be the core hydrogen-burning phase by Brott et al. (2011) and Kohler et al. (2015). Except for five stars, the helium abundance of our sample stars is in agreement with the initial LMC composition. The aforementioned five stars present moderate projected rotational velocities (i.e., $v_{\mathrm{e}}\,\sin\,i\,<\,200\,\mathrm{km\,s^{-1}}$) and hence do not agree with current predictions of rotational mixing in main-sequence stars. Adopting theoretical results for the wind velocity law, we find modified wind momenta for LMC stars that are $\sim$0.3 dex higher than earlier results. [Due to the limitation of characters, the abstract appearing here is slightly shorter than that in the PDF file. ]
Prevalence of metabolic syndrome in obese Chilean children and association with gene variants of the leptin-melanocortin system

Abstract Metabolic syndrome (MS) related to adult type 2 diabetes mellitus and cardiovascular disease is prevalent among obese children/adolescents. Genetic variants of the leptin-melanocortin system have been associated with components of MS. The aim of our study is to estimate the prevalence of MS (according to Cook’s criteria) in a Chilean cross-sectional sample of 259 obese children (47.1% girls, aged 6–12 years), and to assess the association between common genetic variants of leptin-melanocortin pathway genes (LEP, LEPR, POMC, MC3R and MC4R) with components of the MS using logistic regression. We observed an overall MS prevalence of 26.3% (32.2% in girls and 21.1% in boys) in obese Chilean children. No associations were detected between genetic variants of leptin-melanocortin genes and MS components. MS prevalence among our obese children sample is similar to those previously described in Chile, demonstrating the increased risk of diseases in adulthood that obese children carry.
Optimization of cultivation conditions in spin tubes for Chinese hamster ovary cells producing erythropoietin and the comparison of glycosylation patterns in different cultivation vessels

This article describes the optimization of cultivation factor settings, that is the shaking rate and working volume in 50 mL spin tubes for a Chinese hamster ovary cell line expressing recombinant human α‐erythropoietin, using a response D‐optimal surface method. The main objectives of the research were, firstly, to determine a setting in which the product titer and product quality attributes in spin tubes are equivalent to those in 250 mL shake flasks in a seven day batch and, secondly, to find a setting in which the product titer is maximal. The model for product titer prediction as a function of shaking rate and working volume in the defined design space was successfully applied to the optimization of cultivation conditions in spin tubes for the tested cell line. Subsequently, validation experiments were carried out simultaneously in spin tubes, shake flasks and bench scale bioreactors to compare cell culture performance parameters such as growth, productivity and product quality attributes in the form of isoform profiles and glycan antennarity structures. The results of the experiments showed that similar cell culture performance and product quality could be achieved in spin tubes when compared to shake flasks. Additionally, bioreactor titers could be reproduced in spin tubes at high shaking rates and low working volumes, but with differing product quality. Cultivation at lower shaking rates in spin tubes and shake flasks produced a glycoprotein with a product quality slightly comparable to that from bioreactors, but with titers being only two thirds. © 2010 American Institute of Chemical Engineers Biotechnol. Prog. , 2010
Isometric handgrip does not elicit cardiovascular overload or post-exercise hypotension in hypertensive older women

Background Arterial hypertension is a serious health problem affecting mainly the elderly population. Recent studies have considered both aerobic and resistance exercises as a non-pharmacological aid for arterial hypertension treatment. However, the cardiovascular responses of the elderly to isometric resistance exercise (eg, isometric handgrip [IHG]) have not yet been documented. Objective The purpose of this study was to investigate cardiovascular responses to different intensities of isometric exercise, as well as the occurrence of post-isometric exercise hypotension in hypertensive elderly people under antihypertensive medication treatment. Patients and methods Twelve women volunteered to participate in the study after a maximal voluntary contraction test (MVC) and standardization of the intervention workload consisting of two sessions of IHG exercise performed in four sets of five contractions of a 10-second duration. Sessions were performed both at 30% of the MVC and 50% of the MVC, using a unilateral IHG protocol. Both intensities were compared with a control session without exercise. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) at rest (R), during peak exercise (PE), and after 5, 10, 15, 30, 45, and 60 minutes of post-exercise recovery were evaluated. Results No significant changes were observed after isometric exercise corresponding to 30% MVC for either SBP (R: 121 ± 10; PE: 127 ± 14; 5 min: 125 ± 13; 10 min: 123 ± 12; 15 min: 122 ± 11; 30 min: 124 ± 11; 45 min: 124 ± 10; 60 min: 121 ± 10 mmHg) or DBP (R: 74 ± 9; PE: 76 ± 6; 5 min: 74 ± 5; 10 min: 72 ± 8; 15 min: 72 ± 5; 30 min: 72 ± 8; 45 min: 73 ± 6; 60 min: 75 ± 7 mmHg). Similarly, the 50% MVC did not promote post-isometric exercise hypotension for either SBP (R: 120 ± 7; PE: 125 ± 11; 5 min: 120 ± 9; 10 min: 122 ± 9; 15 min: 121 ± 11; 30 min: 121 ± 9; 45 min: 121 ± 9; 60 min: 120 ± 7 mmHg) or DBP (R: 72 ± 8; PE: 78 ± 7; 5 min: 72 ± 7; 10 min: 72 ± 8; 15 min: 71 ± 7; 30 min: 72 ± 8; 45 min: 75 ± 10; 60 min: 75 ± 7 mmHg). Conclusion Our data reveal that cardiovascular overload or post-exercise hypotension did not occur in elderly women with controlled hypertension when they undertook an IHG session. Thus this type of resistance exercise, with mild to moderate intensity, with short time of contraction appears to be safe for this population.
Scientific Publishing.

We may not be able to make you love reading, but scientific publishing will lead you to love reading starting from now. Book is the window to open the new world. The world that you want is in the better stage and level. World will always guide you to even the prestige stage of the life. You know, this is some of how reading will give you the kindness. In this case, more books you read more knowledge you know, but it can mean also the bore is full.
Probabilistic Landslide Tsunami Estimation in the Makassar Strait, Indonesia, Using Statistical Emulation

This paper presents a significant advancement in the understanding of tsunamigenic landslide hazard across the length of the Makassar Strait in Indonesia. We use statistical emulation across the length of the continental slope to conduct a probabilistic assessment of tsunami hazard on a regional scale, across 14 virtual coastal gauges. Focusing on the potential maximum wave amplitudes (distance between the wave crest and the still‐water level) from possible tsunamigenic landslide events, we generate predictions from Gaussian Process emulators fitted to input‐outputs from 50 training scenarios. We show that the most probable maximum wave amplitudes in the majority of gauges are between 1 and 5 m, with the maximum predicted amplitudes reaching values of up to 10 m on the eastern coast, and up to 50 m on the western coast. We also explore the potential use of Gaussian multivariate copulas to sample emulator prediction input values to create a more realistic distribution of volumes along the continental slope. The novel use of statistical emulation across a whole slope enables the probabilistic assessment of tsunami hazard due to landslides on a regional scale. This area is of key interest to Indonesia since the new capital will be established in the East Kalimantan region on the western side of the Makassar Strait.
PDE-constrained optimal control approach for the approximation of an inverse Cauchy problem

This paper concerns the approximation of a Cauchy problem for the elliptic equation. The inverse problem is transformed into a PDE-constrained optimal control problem and these two problems are equivalent under some assumptions. Different from the existing literature which is also based on the optimal control theory, we consider the state equation in the sense of very weak solution defined by the transposition technique. In this way, it does not need to impose any regularity requirement on the given data. Moreover, this method can yield theoretical analysis simply and numerical computation conveniently. To deal with the ill-posedness of the control problem, Tikhonov regularization term is introduced. The regularized problem is well-posed and its solution converges to the non-regularized counterpart as the regularization parameter approaches zero. We establish the finite element approximation to the regularized control problem and the convergence of the discrete problem is also investigated. Then we discuss the first order optimality condition of the control problem further and obtain an efficient numerical scheme for the Cauchy problem via the adjoint state equation. The paper is ended with numerical experiments.
Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR

Background Cardiac infiltration is the major predictor of poor prognosis in patients with systemic amyloidosis, thus it becomes of great importance to evaluate cardiac involvement. Purpose We aimed to evaluate left ventricular myocardial deformation alteration in patients with cardiac amyloidosis (CA) using layer-specific tissue tracking MR. Material and Methods Thirty-nine patients with CA were enrolled. Thirty-nine normal controls were also recruited. Layer-specific tissue tracking analysis was done based on cine MR images. Results Compared with the control group, a significant reduction in LV whole layer strain values (GLS, GCS, and GRS) and layer-specific strain values was found in patients with CA (all P < 0.01). In addition, GRS and GLS, as well as subendocardial and subepicardial GLS, GRS, and GCS, were all diminished in patients with CA and reduced LVEF, when compared to those with preserved or mid-range LVEF (all P < 0.05). GCS showed the largest AUC (0.9952, P = 0.0001) with a sensitivity of 93.1% and specificity of 90% to predict reduced LVEF (<40%). Moreover, GCS was the only independent predictor of LV systolic dysfunction (Odds Ratio: 3.30, 95% CI:1.341–8.12, and P = 0.009). Conclusion Layer-specific tissue tracking MR could be a useful method to assess left ventricular myocardial deformation in patients with CA.
Study of evolved stellar populations in the magellanic clouds

The Magellanic Clouds (MCs) consist of a pair of galaxies, the Large Magellanic Cloud (LMC) and the Small Magellanic Cloud (SMC), which are located at a distance of ∼ 50 kpc and 60 kpc, with stellar masses of ∼ 10 M and 10 9 M , respectively. Morphologically they are categorized as irregular type galaxies. The MCs are gas rich and metal poor (Z=0.008 for LMC, and 0.004 for SMC) as compared to the Milky Way (MW), and have active star-forming regions. Their proximity and location at high galactic latitude enable us to resolve their individual populations as well as detect faint stellar populations. It is well known that the MCs are interacting with each other, as well as with the MW. The interaction is supported by the presence of the Magellanic Bridge and the Magellanic Stream. The evolved stellar populations in the MCs help us to understand their evolution and interaction process. The MCs host both Population I as well as Population II stars. This extended range of star formation is a valuable source of information to understand the formation and evolution of galaxies in general, and the MCs in particular. Evolved stellar population means the stars that have evolved off the main sequence and the giants, such as red giants (RGs), red clump stars, and asymptotic giant branch stars. There is a dominant population of evolved stars present in the MCs, in star clusters as well as in the field. The aim of the thesis is to study the evolved stellar populations for one of the component of the MCs, the LMC. The study is primarily divided into two parts. (1) Study of sparse star clusters in the LMC: To increase our understanding of sparse star clusters in the LMC, with well estimated parameters, using deep Washington photometric data for 45 LMC clusters. (2) To estimate a metallicity map of LMC: In order to understand the metallicity variation across the galaxy. This is done by creating a high spatial resolution metallicity map of the LMC, using
Large cardinals and their effect on the continuum function on regular cardinals

In this survey paper, we will summarise some of the more and less known results on the generalisation of the Easton theorem in the context of large cardinals. In particular, we will consider inaccessible, Mahlo, weakly compact, Ramsey, measurable, strong, Woodin, and supercompact cardinals. The paper concludes with a result from the opposite end of the spectrum: namely, how to kill all large cardinals in the universe.
Investigating and improving student understanding of the expectation values of observables in quantum mechanics

The expectation value of an observable is an important concept in quantum mechanics since measurement outcomes are, in general, probabilistic and we only have information about the probability distribution of measurement outcomes in a given quantum state of a system. However, we find that upper-level undergraduate and PhD students in physics have both conceptual and procedural difficulties when determining the expectation value of a physical observable in a given quantum state in terms of the eigenstates and eigenvalues of the corresponding operator, especially when using Dirac notation. Here we first describe the difficulties that these students have with determining the expectation value of an observable in Dirac notation. We then discuss how the difficulties found via student responses to written surveys and individual interviews were used as a guide in the development of a quantum interactive learning tutorial (QuILT) to help students develop a good grasp of the expectation value. The QuILT strives to help students integrate conceptual understanding and procedural skills to develop a coherent understanding of the expectation value. We discuss the effectiveness of the QuILT in helping students learn this concept from in-class evaluations.
Financial Distress and the Commitment to Promoting Innovation in State-Owned Enterprises: A Critical Perspective

Financial distress in State-Owned Enterprises (SOEs) has been a problematic issue for a long time. By 2020, the total debt of SOEs in Indonesia reach 1.682 trillion Rupiahs, whereas 68% out of all SOEs that receive state capital injections are facing bankruptcy. However, a more critical perspective still needs to investigate how commitment to promoting innovation relates to financial distress in SOEs. The existing studies of financial distress in SOEs have mainly focused on analyzing technical and structural factors and the predictive models using company financial indicators. This study aims to analyze the financial distress and innovation in SOEs critically. This study uses official data of PT Krakatau Steel from 2015-2020 and employs the combined analysis method. Quantitative regression analysis analyzes the company's financial distress throughout the period. In contrast, qualitative content analysis analyzes the relevance of the company's innovation commitment in the same period. The study shows that apart from ineffective capital structure decisions, low commitment to innovation is an important factor influencing financial distress in SOEs. The prospect of restructuring as a short-term strategy is also discussed.
Parameter Estimation of Multivariate Lévy Processes

In this thesis, we apply Levy copulas to describe the dependence structure of multivariate Levy processes and build some Levy copula-based models. Parameter estimation of the models is the main part of this work. The estimation procedure is based on maximum likelihood principles. For compound Poisson processes (CPP) which have finite Levy measure, we decompose the mass on the axes and outside of the axes. This decomposition for a bivariate CPP generates three independent components and shows either the jumps only in one component, or the bivariate jumps in both components. The likelihood function can be derived based on these independent parts. We also suggest a new simulation algorithm for a bivariate CPP. We apply our method to model Danish fire insurance data and estimate the parameters of the model. The extension of the method for Levy Processes with infinite Levy measure is discussed in the second part. More precisely we take a bivariate stable Levy Process and truncate all the small jumps. We base the statistical analysis on the resulting CPP. The Fisher information matrix is also calculated and the asymptotic normality of the estimators is proved as the number of jumps tends to infinity. In this model this may happen either for the observation period going to infinity, or the truncation point going to 0 for a fixed observation period. A simulation study investigates the loss of efficiency because of the truncation. Finally, a new estimation procedure is introduced in the last chapter. The main idea of this approach, which we call two-step method, is similar to IFM (inference functions for margins) for multivariate distribution functions. First, the parameters of the marginal processes are estimated. Then, given the estimates from the first step, we estimate in a second step only the dependence structure parameters. This method is applied to a bivariate α-stable Clayton subordinator with different or common marginal parameters. For the latter, the Godambe information matrix and asymptotic covariance matrix are analytically calculated. Moreover, the asymptotic normality of the estimators is proved as the time span goes to infinity or the truncation point goes to zero. A simulation study compares the quality of all three estimation methods: the two-step estimates, the MLEs of a full model and the MLEs based on joint jumps only.
Caribbean Air Chemistry and Dispersion Conditions

The meteorological influences on Caribbean air chemistry are studied using in-situ, satellite and model data. Although African dust plumes join locally generated pollutants, concentrations are relatively low in the eastern Caribbean due to geographic remoteness and steady oceanic trade winds. Urban-industrial emissions from big cities (e.g., Kingston, Santo Domingo, San Juan), agricultural emissions from the south, and volcanic emissions from Montserrat contribute a noticeable burden. Conditions over Puerto Rico in the dry season (December–May) provide a focus for statistical analysis of air chemistry constituents and weather variables that describe dispersion conditions. Monthly and daily air indices are formed by summing the normalized values of fine aerosols and particulates, long- and short-lived trace gases from in-situ, satellite and model sources. The spatial correlation of a daily Puerto Rico air index onto regional dewpoint temperature, air pressure and outgoing longwave radiation fields in December–May 2005–2015 reveals the northward movement of a dry tongue and trough. At the climate timescale, Pacific El Nino conditions favor an increase of spring-time air pollution corresponding to anomalous inflow from Africa and the southern Caribbean coast. Composite weather patterns for a group of high air index values reflect divergent trade winds and a strong jet stream that imparts anticyclonic vorticity, subsidence and low humidity. This new understanding will underpin better air quality forecasts for Puerto Rico and the wider Caribbean.
Capability for change at community health centers serving Asian Pacific Islanders: an exploratory study of a cancer screening evidence-based intervention.

BACKGROUND Understanding and enhancing change capabilities, including Practice Adaptive Reserve (PAR), of Community Health Centers (CHCs) may mitigate cancer-related health disparities. MATERIALS AND METHODS Using stratified random sampling, we recruited 232 staff from seven CHCs serving Asian Pacific Islander communities to complete a self-administered survey. We performed multilevel regression analyses to examine PAR composite scores by CHC, position type, and number of years worked at their clinic. RESULTS The mean PAR score was 0.7 (s.d. 0.14). Higher scores were associated with a greater perceived likelihood that clinic staff would participate in an evidence-based intervention (EBI). Constructs such as communication, clinic flow, sensemaking, change valence, and resource availability were positively associated with EBI implementation or trended toward significance. CONCLUSIONS PAR scores are positively associated with perceived likelihood of clinic staff participation in cancer screening EBI. Future research is needed to determine PAR levels most conducive to implementing change and to developing interventions that enhance Adaptive Reserve.