Miracle-dz/UniFAR-FTUs huggingface dataset:
Lutein restores synaptic functionality in a C. elegans model for mitochondrial complex I deficiency

Complex I deficiency represents 30% of the pathogenetic causes of human mitochondrial associated diseases (HMAD), thus being the most frequent defect of mitochondrial energy metabolism. Therapeutic options for these devastating, life-threating disorders, which in most cases present with neurodevelopmental defects, do not exist, in part due to the scarcity of appropriate model systems to study them. Caenorhabditis elegans is a powerful, genetically tractable model organism widely used to investigate neuronal development and degeneration. Here, we generated new C. elegans models for HMAD, which closely recapitulated the human pathologies, and we focused on two complex I disease models associated with Leigh Syndrome, nuo-5/NDUFS1- and lpd-5/NDUFS4-depleted animals, which were exploited for a suppressor screening. We identified lutein, among a library of natural compounds, for its ability to rescue the developmental arrest and neuronal deficits in the two models. Specifically, we found that lutein exerts its beneficial activity through suppression of a synaptic defect we disclosed for the first time upon nuo-5/NDUFS1 depletion, thus pointing to possible novel therapeutic targets for the human disease.
Religious and Cash Holding: Evidence from Indonesia

This research examines the effect of religiosity on the cash holding. The method used to test the model is panel data regression by investigating the effect of religiosity on the cash holding of shari'a and non-shari'a companies. The results show that Religiosity (Islamic Dichotomic), showing a positive and significant coefficient on cash holdings. Companies with a high level of religiosity hold significant amounts of cash. The companies hold cash to reduce risk by reducing debt financing. Keywords: cash holdings, religiosity, risk
Between Two Masters: Dilemmas of English Language Teaching in Iraq Today

This qualitative case study explored how some Iraqi English language teachers respond to and negotiate these factors. It examined how these Iraqi English language teachers construct, shape and re-shape their identities within the religious, cultural, social, and political context of Iraq. Two groups of teachers participated in this study: Ten Iraqi English teachers who are a current secondary school English language teachers and living in Iraq and ten Australian TESOL trained Iraqi teachers who were intending to return to Iraq. Data were collected in Iraq and Australia in two stages: focus group discussions and semi structured interviews.
An Alternative Design Method for the Seismic Retrofit of RC Moment Resisting Frame Buildings with Viscous Dampers

ABSTRACT An alternative design methodology which can be conveniently adopted by practicing engineers is proposed to enhance the seismic performance of existing reinforced concrete moment resisting frame (RC-MRF) buildings by employing viscous dampers. Here, the response indicators of the unretrofitted building are calculated using nonlinear response history analysis (NLRHA); viscous damper characteristics are calculated by estimating the peak viscous damper forces in terms of supplemental viscous damping and peak story shear forces of the unretrofitted building; and currently available expressions are used for the displacement profile of the retrofitted building and the equivalent single degree of freedom (SDOF) system displacements, to calculate the supplemental viscous damping. The effectiveness of the distribution of the viscous damper constants proportional to story parameters is also investigated.
AL Amyloidosis: Unfolding a Complex Disease

Light chain (AL) amyloidosis is a rare plasma cell dyscrasia. An estimated 12,000 people live with the disease in the United States. AL amyloidosis occurs from the misfolding of proteins that deposit in organs (heart, kidneys, digestive tract, tongue, lungs, and nervous system), leading to progressive organ damage and impairment of quality of life. The treatment of AL amyloidosis has improved greatly over the past several years, with new treatments currently in development. This article will focus on the pathophysiology, diagnosis, and treatment of AL amyloidosis.
Alcohol, women’s clothing, and the perception of sexual intent

ABSTRACT This study investigated factors involved in sexual information processing when alcohol is involved. Seventy-two male and 90 female participants viewed one of four videos of a heterosexual dyad interacting where the females’ clothing (sexualized/non-sexualized) and drink consumed (alcohol/water) was manipulated, and completed personality questionnaires. It was hypothesized the condition containing sexualized clothing, alcohol consumption and a male participant viewing the video would infer the greatest level of perceived sexual intent. Results yielded support for an effect of clothing. Also, men, compared to women, were significantly more socio-sexually inept, sexually pre-occupied, adopted a masculine sex role orientation and held conservative attitudes toward women. However, the feminine sex role orientation was not adopted significantly more by females when compared to males. The results of this study re-affirm the strong link between sexualized clothing and misperception, reinstating the need for clear verbal communication of sexual/platonic intentions. Recommendations are made for future research.
Knowledge, Attitudes and Practices among Parents of School-age Children after Child Sexual abuse Prevention Education

Background & Aim: Child sexual abuse is a serious social problem which is a priority health issue in many countries due to profound impact on child’s growth and personality. This study was conducted to explain the effect of child sexual abuse prevention education program on knowledge, attitudes and practices of parents with children aged 6 to 12 years. Material & Methods: A quasi-experimental study was conducted with a pretest-posttest design with the control group. A convenience sampling method was used to recruit a sample of parents referring to Health Centers in Aligoudarz, Iran. Participants were recruited and enrolled in the experimental (n = 50) or control group (n = 50). This study was conducted using Persian version of “Child Sexual Abuse” (CSA) questionnaire. The experimental group received education about identifying different types of child sexual abuse and preventing methods, focused on the importance of family and the role of parents in the prevention of sexual abuse and providing self-protection training for children. Different methods including questions and answers, group discussion, lecture, educational film, brochures and booklet were used to educate parents during the four (60 minutes) sessions. Data collecting took 6 weeks after intervention from parents in both groups and data analyzing have been done via paired and independent samples t-test, chi-square and fisher tests using SPSS software (version 16). Results: The results showed significant difference in terms of the mean scores of knowledge and performance of parents after 6 weeks of training (P <0.05). Conclusions: The findings of this study revealed that designing and implementing training programs for the prevention of child sexual abuse can lead to increased knowledge and practice of the parents but making change of attitude requires more studies. It is recommended that further studies should be conducted in teachers working in schools and kindergartens.
Issues and opportunities when using rating scales to identify creatively gifted students: Applying an IRT approach

ABSTRACT Identifying creatively gifted students remains a challenging yet important task. Often, teacher rating scales are used to assess students’ creative behaviors; however, the school environment may not always provide opportunities for students to demonstrate creative ability, making it challenging for teachers to observe students’ creative potential. Therefore, the purpose of this study was to (1) explore students’ perceptions of their own creativity, (2) determine the discriminatory validity of the creativity subscale of the Scales for Identifying Gifted Students (SIGS-C), and (3) compare students’ and teachers’ ratings on the SIGS-C. Data were collected from 236 middle and high school students and their teachers in the United States. Significant differences existed between how students perceived their creativity in general and at school (t(217) = 7.946, p < . 001), and their SIGS-C scores more closely correlated with their general ratings (r = .64, p < .001) than their school ratings (r = .20, p < .001). SIGS-C items were analyzed using an IRT approach, and two items (breaking gender stereotypes, spending time alone) did not adequately differentiate between levels of creativity on teacher or student rating scales. Finally, teachers’ ratings were minimally but significantly correlated with the students’ ratings (r = .14, p = .046), demonstrating the importance of considering multiple sources of data when identifying creatively gifted students.
What Image Features Boost Housing Market Predictions?

The attractiveness of a property is one of the most interesting, yet challenging, categories to model. Image characteristics are used to describe certain attributes, and to examine the influence of visual factors on the price or timeframe of the listing. In this paper, we propose a set of techniques for the extraction of visual features for efficient numerical inclusion in modern-day predictive algorithms. We discuss techniques such as Shannon's entropy, calculating the center of gravity, employing image segmentation, and using Convolutional Neural Networks. After comparing these techniques as applied to a set of property-related images (indoor, outdoor, and satellite), we conclude the following: (i) the entropy is the most efficient single-digit visual measure for housing price prediction; (ii) image segmentation is the most important visual feature for the prediction of housing lifespan; and (iii) deep image features can be used to quantify interior characteristics and contribute to captivation modeling. The set of 40 image features selected here carries a significant amount of predictive power and outperforms some of the strongest metadata predictors. Without any need to replace a human expert in a real-estate appraisal process, we conclude that the techniques presented in this paper can efficiently describe visible characteristics, thus introducing perceived attractiveness as a quantitative measure into the predictive modeling of housing.
The experience of thriving at work for managers in the private and public sector

Thriving at work is a concept that has been influenced by a range of perspectives, including the thriving as a response to trauma and concepts of wellbeing, flourishing and happiness. The most influential theory of thriving at work in the extant literature as a combination of learning and vitality has informed a series of studies leading to a conceptual framework of antecedents, behaviours and outcomes. This thesis contends that thriving at work may differ across roles and explored the experience of thriving at work for managers in one public and one private sector organisation in the UK in order to understand their perceptions of cultural and individual factors that influence this experience. An integrated literature review identified the theoretical foundations of this debate, as well as critical questions to be addressed in this study, and informed the choice of a qualitative inquiry and a social constructivist paradigm. Semi-structured interviews incorporating the critical incident technique were carried out with 30 managers, and retrieved data was analysed using template analysis. This analysis identified three themes: trust as a foundation of thriving at work; making a difference as generating thriving at work; and the iterative, cumulative and emotive nature of thriving at work. The responses amplify the importance of immediate context, compared to broader cultural and demographic influences. Furthermore, the priority and weighting given to each factor varied significantly by individual, suggesting thriving at work is more personal than has been captured by current definitions and theories. A re-examination of the theoretical determinants of thriving at work suggests psychological safety and meaningful work could offer greater insight into the phenomenon for managers, and a new paradigm is proposed that reflects this theoretical position whilst placing greater emphasis on the individual nature of the concept.
Mental and motor development of Peruvian children treated for severe malnutrition

Twenty-seven children from the slums of Lima, Peru hospitalized and treated for severe protein-calorie malnutrition were given the Bayley Infant Scale of Mental Development and the Bayley Infant Scale of Motor Develop­ment. They ranged in age front eleven to thirty-two months with a mean age of 19.5 months. Only two of the children obtained scores above the basal levels of the Scales, thus indicating severe mental and motor retardation despite their apparent somatic recovery from starvation. There was, however, a degree of motor improvement relative to the duration of hospitalization. Eight sibling controls from the slums scored with the normal range for their age, according to the American standardization of Scales.
The correlation of CBCT analysis derived bone density parameters with primary implant stability - a clinical study

Background/Aim. There are numerous studies on the usefulness of computed tomography (CT) in the assessment of the bone volume and morphology and on the relationship between CT and primary implant stability. But there is the scarcity of data about the correlation between bone density and the value of primary implant stability. The aim of this study was to examine the correlation of cone beam CT (CBCT) analysis derived bone density with primary stability value. Methods. Clinical prospective experimental study was conducted on 38 healthy patients missing one tooth in the lateral region. It was planned to install Bredent Blue Sky Narrow self-taping dental implants with dimensions 3.5 ? 10 mm. During preoperative preparation, a CBCT scan was performed on Planmeca apparatus, followed by preimplantation measurements and planning in the CBCT apparatus software (Romexis). The mean value of the average bone density was automatically generated and expressed in Hounsfield units (HU). Upon implant placement, we performed measurements of the primary implant stability using Osstell apparatus. Results. Of the 38 patients included in the study, there were 68.4% male patients and 31.6% female patients. The arithmetic mean of the measured bone density of all subjects in the study amounted to 536.2 HU. The arithmetic mean of dental implant primary stability for all subjects in the study was 68.7 ISQ. There was a statistically significant strong positive connection between HU and ISQ (r = 0.744, p < 0.001). Higher HU values were connected to higher ISQ values. In the multivariate linear regression model, statistically significant predictors of higher ISQ values: males (B = 4.669; p = 0.047) and higher HU values (B = 0.032; p < 0.001). Conclusion. In our clinical study, there was a statistically significant strong positive correlation between the bone density expressed in HU units, measured in the software of the CBCT device and the primary stability of dental implants expressed in ISQ units.
The Impact of an Intensive Educational Program Regarding Preeclampsia on Health Professional Knowledge

Preeclampsia is a multi-system disorder unique to human pregnancy with multi-system involvement. Worldwide, it causes ]500,000 fetal and neonatal deaths and ]70,000 maternal deaths every year. Limited knowledge of health professionals in direct connection with complications of pregnancy, and inability to keep up with medical knowledge, has potentially severe effects on the quality of care and increases maternal and perinatal mortality. The aim has been to identify the impact of an intensive educational program regarding preeclampsia on health professionals knowledge at Clinical Hospital of Obstetrics and Gynecology Polizu in Bucharest, Romania. The study design was quasi-experimental. A total of 89 health professionals, including 12 resident physicians, 12 midwives and 65 nurses at Clinical Hospital of Obstetrics and Gynecology Polizu in Bucharest in the Department of Obstetrics and Gynecology participated in the study. The study was designed in three phases: Assessment phase, Implementation phase and Evaluation phase. The intensive educational program regarding preeclampsia has a highly significant positive influence on the knowledge of health professionals. There was a clear transfer of knowledge among the participants. The following resulted across all 31 examined knowledge areas: Resident physicians: Category Score /Criteria Pre-Test (No./%): Inadequate 1 (8.3%), Moderate 9 (75%), Adequate 2 (16.7%), Midwives: Category Score /Criteria Pre-Test (No./%): Inadequate 8 (66.7%), Moderate 4 (33.3%), Adequate 0 (0%), Nurses: Category Score /Criteria Pre-Test (No./%): Inadequate 60 (92.3%), Moderate 5 (7.7%), Adequate 0 (0%). After Trainingsprogramm, the amount of knowledge in the field preeclampsia increased impressively: Resident physicians: Category Score /Criteria Post-Test (No./%): Inadequate 0 (0%), Moderate 0 (0%), Adequate 12 (100%), Midwives: Category Score /Criteria Post-Test (No./%): Inadequate 0 (0%), Moderate 3 (25%), Adequate 9 (75%) with a (p[0.002), Nurses: Category Score /Criteria Post-Test (No./%): Inadequate 0 (0%), Moderate 10 (15.4%), Adequate 55 (84.6%) with a (p[0.001). Based on the findings of the study, it can be concluded that the intensive educational program regarding preeclampsia led up updating of the knowledge and improved qualification of the health professionals. This is expected to improve the quality of care for patients and reduce maternal and perinatal preeclampsia-related mortality in Romania.
Content Knowledge Courses in Physical Education Programs in South Korea and Ohio

Lack of content knowledge in teachers is one of the most challenging tasks confronting teacher education. We examine the extent to which content knowledge taught in pre-service physical education licensure programs in South Korea and Ohio focused on the performance of content or the teaching of content. One representative syllabus from each of 21 (87%) South Korean licensure programs and 17 (61%) of Ohio licensure programs were examined to determine the percentage of the grade assigned to performance and teaching of content. One-way and two-way Chi-square analyses were conducted. All of the programs in South Korea focused exclusively on performance. In Ohio, a majority of programs focused on performance. South Korea and Ohio licensure programs are more similar than different in their emphasis on performance of content over the teaching of content. This finding raises questions about how pre-service teachers in physical education acquire knowledge to teach content.Key Words: Pedagogical content knowledge, physical education teacher education, cross-cultural analysis
Evaluation and Treatment of Chronic Plantar Fasciitis

Plantar fasciitis is the most common cause of chronic heel pain in adults, affecting both young active patients and older sedentary individuals. It results from repetitive stress to the plantar fascia at its origin on the medial tubercle of the calcaneus and is often associated with gastrocnemius tightness. The diagnosis can be made clinically with a focused history and physical examination; imaging is reserved for atypical presentations and those that do not respond to initial treatment. The most common presenting symptom is aching plantar heel pain, which is worst with first step in the morning or after periods of rest. Diagnosis is confirmed with point tenderness at the origin of the plantar fascia on the medial tubercle of the calcaneus. Initial treatment consists of activity modification, anti-inflammatory medication, gastrocnemius and plantar fascia stretching, and an in-shoe orthosis that lifts and cushions the heel. These nonoperative treatments lead to complete resolution of pain in 90% of patients but can take 3-6 months. Patients who remain symptomatic despite a 6-month trial of nonoperative therapy may be considered for minimally invasive treatment or surgery. Platelet-rich plasma injections and therapeutic ultrasound are among a number of minimally invasive treatments that stimulate the body’s healing response. Corticosteroid injections temporarily relieve pain, but may increase the risk of plantar fascia rupture and fat pad atrophy. Botulinum toxin injections relax the calf muscles, which decreases the stress in the plantar fascia. Operative treatments include gastrocnemius recession and medial head of gastrocnemius release, which decrease the stress on the plantar fascia and partial planter fasciotomy, which stimulates a healing response. Level of Evidence: Level V, expert opinion.
Investigation of bifid mandibular canal frequency with cone beam computed tomography in a Turkish population

Objectives : It is important to know anatomic location and variations of the mandibular canal (MC) for surgical treatment on mandible such as implant operations, impacted molar tooth extraction and sagittal split ramus osteotomy. The purpose of our study is to determine the configuration and incidence of bifid mandibular canal (BMC) using cone beam computed tomography (CBCT). Methods: CBCT scans of 2000 patients were retrospectively analysed. Age and gender of the patients who were included in this study were recorded. BMC was subdivided, frequency was determined. Measurements of mean lengths, superior and inferior angles were performed. The all measurements were performed by one observer in 3 times at intervals of one week to confirm intra-observer reliability. SPSS 21 (Statistical Package for Social Science 21) was used for statistical analysis. It was benefited from Chi-square test to investigate qualitative observation and from T test and one-way analysis of variance for investigation of quantative observation. Differences were considered significant at p<0.05. Results: 1122 of 2000 patients (56.1%) were females and 878 of 2000 patients (43.9%) were males. BMC was observed in 61 of 2000 patients (3.05%). Because location of MC is bilateral, 122 sides in 61 patients were studied. BMC was observed in 65 of 122 sides (53.3%). In 39 of 65 sides (60%), BMC was observed in males, in 26 of 65 (40%) sides, BMC was observed in females. Conclusion: CBCT provides important informations about MC imaging and evaluation of variations. Evaluation of MC variations frequency and informing to surgeon in surgical procedures on mandible provides advantages for successful operations.