Miracle-dz/UniFAR-FTUs huggingface dataset:
Health seeking behavior of β-thalassemia major children and its attributes: An epidemiological study in Eastern India

Background: Health seeking behaviour (HSB) of thalassemic children is one of the rarely explored entity. Aim: To explore HSB of β-Thalassemia Major (β-TM) children and its attributes. Materials and Methods: It was a cross-sectional design, observational study, conducted among 328 β-TM children and their caregivers attending a tertiary care health facility of Kolkata; West Bengal situated in Eastern India in between May 2016 and April 2017 with a structured schedule. The data were analyzed using SPSS 16.0 version. Results: At the disease onset, 79.6% of them consulted an allopathic doctor. In multivariable logistic regression model, those who were residing in urban area [adjusted odds ratio, AOR: 3.2 (1.2-8.7)], Hindu by religion[AOR: 3.0 (1.2-7.4)], had educated parents [AOR: 3.2 (1.1-9.2)], no family history of the disease [AOR: 3.6 (1.5-8.5)], belonged to higher socio-economic status (Class II, III and IV) [AOR: 2.9 (1.2-6.8)] and had caregiver with satisfactory knowledge related to the disease (≥4)[AOR: 12.2 (5.1-29.6)] were significantly more likely to seek healthcare from an allopathic doctor at onset of the disease. When we consider their HSB till date, 61.0% continued to consult allopathic doctors only. The multivariable determinants of satisfactory HSB till date were place of residence [AOR: 2.7 (1.4-5.2)], caste [AOR: 3.3 (1.6-6.7)], religion [AOR: 3.4 (1.7-6.9)], family history of the disease [AOR: 2.3 (1.2-4.6)] and caregiver's knowledge related to the disease [AOR: 5.3 (3.1-9.2)]. Conclusions: HSB of the study participants were significantly associated with their caregiver's knowledge regarding the disease, parents' educational level, socio-economic status, caste, religion and family history of the disease.
Evaluation of morphological characteristic and varieties of tongue prints for personal identification in Kanpur communities: An impression-based analysis

Context: The human tongue, a unique organ with complex architecture, exhibits significant morphological variations in the human body consistent with its complex role. Its morphological characteristic features and varieties can go about as proof of life and can be used for personal identification. The morphology and surface highlights of the tongue are qualities of each person, and these characteristics can be utilized as legal distinguishing proof of each person. Aims: This study is aimed to analyze varieties in morphological qualities of the tongue and to find out gender differences. Settings and Design: This study was conducted on 206 (Group I consist of 105 females and Group II consist of 101 male) participants with an age range of 21–30 years for 4 months who had visited the Department of Oral Medicine and Radiology. Subjects and Methods: The tongue was exposed to visual assessment following which alginate impression of the dorsal surface of the tongue was taken to make tongue cast and to assess distinct morphological features of the tongue and its variations in males and females. Statistical Analysis Used: The discrete (categorical) data were summarized in number (n) and percentage (%) and compared using the Chi-square (χ2) test. Results: A total of 206 participants in both groups, the U-shaped tongue, was the most common findings in males, as well as in females followed by a V-shaped tongue with a sharp tip that was observed more in females compared to males. Scalloped borders and multiple fissures were more common in males as compared to females. Conclusions: Variations of tongue shape and surface properties can be used as personal human identification in forensic odontology, and tongue prints can also be used as a standard method for the collection of data. The collected data of tongue prints may be used as a professional recognition database to ease human identification and to avoid future scams.
Short-term outcome of botulinum neurotoxin A injection with or without sodium hyaluronate in the treatment of infantile esotropia—a prospective interventional study

Purpose: To compare the short-term outcome of botulinum neurotoxin A (BoNT-A) with or without sodium hyaluronate in the treatment of infantile esotropia (IE). Methods: In this tertiary care hospital-based prospective, interventional, non-randomized study on infants with IE below one year of age, 25 cases were enrolled in the sodium hyaluronate (SH) group to receive 2.5 U BoNT-A injection combined with SH in each medial rectus muscle (MR). Thirty patients were enrolled in the control group to receive 2.5 U BoNT-A injection with normal saline in each MR. The change in mean primary ocular deviation (POD) and complications were assessed at 2 weeks, 1 month, 3 months, and 6 months post injection. Mann–Whitney U test was used for non-parametric unpaired data. Chi-square test and Fisher's exact test were used to test for the strength of the association between the two categorical variables. Results: Satisfactory ocular alignment was achieved in 76% in SH group and 73% in the control group (P value = 0.80). While the change in mean POD was comparable (29.2 prism diopters [PD] vs 29.3 PD; P value = 0.65), the complication rates were significantly lesser in SH (16% vs 33.3%; P value = 0.14). Conclusion: BoNT-A combined with SH is equally effective with lesser complications as compared to botulinum toxin alone in the treatment of IE.
A study of C-reactive protein and D-dimer in patients of appendicitis

Background: Acute appendicitis is the most common abdominal surgical emergencies across the world. Objective: The aim of this study was to determine the value of C-reactive protein (CRP) and D-dimer as diagnostic markers of acute appendicitis. Study Design: It was a Prospective observational clinical study. Method: The present study was carried out in General Surgical Unit of University Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi from September 2015 to July 2017. All data including patient's demography, clinical examination, laboratory test results, and appendix histology were summarized. Receiver operating characteristic (ROC) curve of TLC, CRP, and D-dimer was analyzed. Results: Total 65 patients who presented with periumbilical pain or pain in right iliac fossa (RIF) were included in the study. The mean age of the patients was 31.18 ± 14.59 years (range: 15 to 65 years) with male : female ratio was 2.21:1. The most common symptom was pain in right iliac fossa (100%) followed by nausea/vomiting (69.2%). The mean leucocyte count, CRP, and D-dimer levels were significantly raised in appendicitis group as compared to negative appendicectomy group (P = 0.025, P = 0.036, and P = 0.025, respectively). The receiver operating characteristic (ROC) curve for TLC was not helpful for differentiating between appendicitis and negative appendicitis (P = 0.073). In addition, D-dimer was helpful for differentiating between appendicitis and negative appendicitis (P = 0.002). However, CRP was also found to be helpful for differentiating between appendicitis and negative appendicitis (P = 0.030). Conclusion: The diagnosis of appendicitis remains multifactorial and biochemical markers like CRP and D-dimer may help to guide the surgeon in the decision making.
Epidemiological determinants of low birth weight: A prospective study

Context: Infant and child survival is recognized as an essential ingredient for the overall health of a society. Aims: To study the magnitude and epidemiological determinants of LBW. Settings and Design: Community-based longitudinal study. Subjects and Methods: A prospective study was conducted for a period of 1 year in Block R.S Pura, Jammu where 364 pregnant women registered at four randomly selected PHCs were followed to assess the magnitude of LBW and to study its association with various determinants. Statistical Analysis Used: Data was analyzed using MS Excel and Open epi version 3.01. Results: Severe anemia, heavy physical activity, low socioeconomic status, illiteracy, extreme ages, and short stature of women were found to be significantly associated with a higher incidence of LBW babies. Conclusion: There is a need to focus on the sensitization of grass-root level health workers as well as pregnant females and their families on the importance of antenatal care, good dietary practices, etc., Thus, strengthening the primary health care system is vital in ensuring optimum health of both mothers and newborns.
Evaluation of knowledge and practice of ASHAs, regarding child health services in Vijyapaura District, Karnataka

Background and Aims: NHM has created a cadre of trained female community health activists called Accredited Social Health Activists (ASHAs) to mobilize the community toward increased utilization of existing health services. ASHAs play an important role in the rollout of government health programs such as the Janani Suraksha Yojana (JSY), a conditional cash transfer scheme to incentivize women to give birth in a health facility. The ASHAs work closely with other frontline workers like Auxiliary Nurse Midwives (ANMs) and Anganawadi Workers (AWWs) to conduct community-level activities. Method: A cross-sectional study was conducted in 11 months. A pre-designed, semi- structured questionnaire was prepared in accordance with the study objectives. The questionnaire was prepared in English and the interview was conducted in Kannada language by explaining them questions one by one. Data collection was done by interview technique. Results: Out of 617 ASHAs interviewed, 580 (94%) ASHAs had proper knowledge about exclusive breast feeding and the duration, 560 (90.7%) told colostrum was necessary to the baby. Only 323 (52.3%) ASHAs had correct knowledge regarding schedule of immunization. 580 (94%) ASHAs could tell when the weaning should be started correctly and 611 (99%) ASHAs knew about ORS packets and the steps that went in preparing it. Conclusion: Generally, knowledge of ASHAs about care of new-born and child health care was considerably good. However, knowledge of ASHAs about the immunization schedule was found to be inadequate.
Levels of Germinable Seed in Topsoil and Cattle Faeces in Legume-grass and Nitrogen-fertilized Pastures in South-East Queensland

Measurements were made of germinable seed of all species in the top 5 cm of soil beneath 9 paddocks in an 11-year-old pasture experiment in south-east Queensland. The experiment comprised two pasture types grazed by cattle: legume-grass (Macroptilium atropurpureum- Setaria sphacelata) pastures grazed at four stocking rates and nitrogen fertilized S. sphacelata pastures grazed at five stocking rates. Levels of germinable seed in the soil varied with pasture type and stocking rate and ranged from 6760 to 45480 seeds/m2. Seed reserves increased on the legume-grass pastures as stocking rate increased. Fifty-seven different plant species were identified from the seedlings grown from the soil seed reserve. For 11 of these species, which contributed 70% of the seed reserves, there were significant trends in relation to pasture type and/or stocking rate. The only species where seed reserves significantly decreased with increasing stocking rate were the two sown species. Cattle faeces were also collected from lightly and heavily stocked legume-grass and nitrogen-fertilized pastures in spring, summer, autumn and winter. Germinable seed contents of all species were measured. Seed content of faeces was higher in the summer and autumn than in the winter and spring samplings, and in the heavily stocked than in the lightly stocked pastures. The highest content recorded was 20.5 germinable seeds g-1 faecal dry matter. The species with the highest germinable seed content in faeces were Digitaria didactyla, Axonopus affinis and Eleusine indica, the latter being restricted to nitrogen-fertilized pastures. Seed dissemination in faeces is a factor contributing to the invasiveness of prostrate perennial grasses such as D. didactyla and A. affinis under heavy grazing.
State of mental health services in various training centers in India during the lockdown and COVID-19 pandemic

Background: There is some information from different developed coutries that mental health services have been badly affected by the COVID-19 pandemic. Little information is available from India. Aim: The aim of this study was to evaluate the impact of lockdown and COVID-19 pandemic on mental health services in India's various training centers. Materials and Methods: In an online survey, information was collected from various training centers of India through E-mail or WhatsApp. Results: Responses were received from 109 institutes. The majority of the responses were received from state-funded government medical colleges and private medical colleges. Since the lockdown and COVID-19 pandemic, brain stimulation treatments have completed stopped. Other, most affected services included electroconvulsive therapy, inpatient services, outpatient services, and psychotherapy services. However, there was an expansion of teleconsultations services because of the lockdown and the COVID-19 pandemic. In three-fourth of the centers mental health services were being provided to the patients with COVID-19 infection. In most of the institutes, mental health professionals were involved at different levels in the COVID-19 responsibilities. These included providing helpline services to the general public, screening people in quarantine for mental health issues, providing clinical care to COVID-19 patients, screening health care workers (HCWs) for mental health issues, and training the HCWs. Conclusion: COVID-19 pandemic and lockdown have led to the collapse of regular mental health services. The present study also shows that mental health professionals are playing a significant role in addressing the prevailing psychiatric morbidity, specifically related to the COVID-19 related issues, and taking care of the HCWs.
Sociodemographic profile and pattern of substance abusers: A retrospective study to unveil the public health problem of Punjab

Introduction: Substance abuse refers to the harmful or hazardous use of any psychoactive substance including licit and illicit drugs, other than when medically indicated. According to a UN report, 1 million heroin addicts are registered in India, and unofficially, there are as many as 5 million. Among all the states Punjab stood third in substance abuse and also injectable drug use. The present study was thus conducted to assess the sociodemographic profile and pattern of substance abuse among patients attending a Drug de-addiction centre. Material and Methods: A record-based analysis from March 2015 to March 2019 was done. Substance dependence was diagnosed post detailed clinical interview by a consultant psychiatrist at the center using DSM -10. For the 966 registered patients admitted in the last four years, the record was checked for completeness of data and relevant information on socio-demographic profile, substance abused, duration of hospital stays, drop out and relapse rates was extracted. Results: Of the total admitted patients (n= 966) 100% addicts were of male gender and natives of Punjab. 514 (53.21%) were married followed by 434(44.93%) never married. Maximum patients 456(47.20%) were self-employed. Heroin was the most abused drug. The injecting route of drug abuse was used by most of the abusers i.e. 51.66%. Only 173 (17.90%) patients dropped out of the treatment followed by relapse in 192 (19.88%). Conclusion: In this paper we demonstrated the vulnerability of young population towards drug addiction. Easy accessibility of drugs, peer pressure and difficult family circumstances raises the fragility to restore for substance use. However, community-based studies are imperative in order to estimate how big is the problem at the bottom.
A prospective interventional study to evaluate the effects of medical therapy (Mifepristone 25 mg) on the management of uterine fibroids

Background and Objectives: In India, the uterine fibroid is a common indication of hysterectomy. An effective option for medical treatment may decrease the morbidity associated with hysterectomy. We aimed to evaluate the effect of mifepristone (25 mg), progesterone antagonist, on uterine fibroids in perimenopausal women. Methods: Fifty-four perimenopausal women of age ≥18 years having symptomatic uterine fibroids were selected from Gynecology OPD and given 25 mg mifepristone once daily continuously for 2–4 cycles of 3 months each. Variables such as baseline fibroid size, position, and hemoglobin were measured and followed at 3, 6, 9, and 12 months. The data were entered in MS EXCEL spreadsheet and analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0. A P value of <0.05 was considered statistically significant. Results: Majority were intramural fibroids (70.37%) followed by submucosal in 16.67%. Size of fibroids ranged from <3 to >7 cm; the majority of fibroids were in 5–7 cm size. No significant association of location with the size of fibroid was found. Out of 54 cases included in the study, change in size in uterine fibroids was observed in 98.14% cases. There was an increase in hemoglobin, from 8.6 g% at baseline to 9.7 g% at 12 months. Conclusion: Mifepristone resulted in a reduction in uterine fibroids size and an increase in hemoglobin at the end of 12 months. It may be an option for uterine leiomyoma treatment, as it is given orally, cost-effective and has minimal side effects.
Post-stroke BDNF concentration changes following proprioceptive neuromuscular facilitation (PNF) exercises

Background: Brain-derived neurotrophic factor (BDNF) plays an important role in repairing normal as well as in the injured brain. Physical exercise may have a positive impact on the release of BDNF. Objective: PNF is a neurophysiological approach that facilitates the stimulation of central and peripheral nervous systems. In this study, our aim was to assess the levels of BDNF as well as functional recovery before and after the intervention of PNF in patients with acute stroke. Methods: A total of 208 patients with first time confirmed stroke were recruited and assessed for stroke severity, type, mini-mental state exam (MMSE), functional independence measure scale, and BDNF levels before and after PNF intervention. BDNF levels were also assessed in healthy individuals for control values. Results: A significant decline in levels of BDNF was observed after in stroke. BDNF levels in patients (with different risk factors) with diabetes, hypertension and DM+ HTN, alcohol, and smoking history were 8.8 ± 4.04 ng/mL, 8.86 ± 4.68 ng/mL, 8.65 ± 3.26 ng/mL, 8.51 ± 4.26 ng/mL, and 8.9 ± 3.4 ng/mL, respectively. A decline in BDNF levels was observed in accordance with the severity of stroke in both ischemic and hemorrhagic stroke with the least level being in severe stroke (NIHSS >15 and ICH >3). Despite the type of stroke and the presence of risk factors, a significant improvement in BDNF levels and FIM scale scores was seen in all subjects who received PNF exercises. Conclusion: Thus, PNF is efficient in improving functional level in acute stroke irrespective of the type of stroke and risk factors.
Prevalence and predictors of adverse reactions in plateletpheresis donors with the perspective of donor safety in a tertiary care hospital of Northern India

Background: Plateletpheresis procedures are generally safe and associated with low adverse reactions. Although donor reactions and injuries are self-limited events, they may discourage donors from future platelet donations. Aim: The purpose of this study was to determine the prevalence and predictors of adverse donor reactions in plateletpheresis donors, which could serve as targets for interventions to reduce reactions. Materials and Methods: The study included 106 platelet donors over a period of 2 years. The demographic, biometric, and clinical parameters were noted. The data were analyzed for predictors of adverse donor reactions. Statistical Analysis Used: The data were analyzed using independent sample t-test to correlate donor variables such as gender. To correlate other variables such as age, weight, and whole blood processed, Chi-square test was used. Results: A total of 106 plateletpheresis donations were performed and 13.2% of vasovagal reactions were observed. The significant predictive factors for reactions were young female donors with low body weight in which more than 2.5 L volume of whole blood was processed and more than 250 ml of acid, citrate, and dextrose-A was infused and with single venous access procedures. Conclusions: The results of this study are encouraging and helpful in identifying donors at risk for developing adverse reactions during plateletpheresis so that proper and close observation during and after donation as well as timely intervention can prevent most of the unpleasant events of plateletpheresis donors.
Clinical and histopathological study of brooder pneumonia in broiler farms

The outbreaks of aspergillosis in broiler chicks (4-15 days old) were observed from January to July, 2011 in five broiler farms. The disease was detected on the basis of clinical signs, gross, histopathological and cultural findings. Infected chicks showed signs of ruffled feathers, green watery diarrhea, anorexia, gasping and dyspnea. On examination, numerous small white yellowish nodules were seen in the lungs, air sacs, kidneys, thoracic wall and abdominal serosa. Microscopically the lungs revealed granulomas with central areas of caseation surrounded by heterophils and giant cells. Aspergillus fumigatus could be isolated in Sabouraud’s dextrose agar from the lesions. Higher morbidity (76 to 100%) and mortality (62.5 to 100%) rates were recorded in the five farms. This is the first record on the occurrence of acute aspergillosis in broiler chicks from Sulaimania/ Iraq.
Confirmatory factor analysis of the Depression, Anxiety, and Stress Scale among Indian adults

Background: The Depression, Anxiety, and Stress Scale (DASS) is a widely used measure of negative emotional states. While the DASS is increasingly used in mental health research in India, to date no study has examined the factor structure among Indian adults. Methods: A large community sample of English-speaking Indian adults completed the DASS 21-item version, and confirmatory factor analyses were conducted. Results: The results indicated a good fit for a three factor (depression, anxiety, and stress) and a one-factor model (general psychological distress). There was no substantial difference between the fit of the models, and the DASS subscales were very strongly correlated with one another (r ≥ .80). Conclusion: The findings from this sample suggest that the DASS-21 items appear to assess general psychological distress, with little evidence that the items assess three distinct subscales.
Genetic tagging to determine passive integrated transponder tag loss in lemon sharks

Multilocus genotypes using nine DNA microsatellite loci provided an effective and permanent individual identification mark for lemon sharks Negaprion brevirostris, the first example of genetic tagging for any elasmobranch species. The double-tagging provided by micro-satellites afforded a means to determine passive integrated transponder (PIT) tag shed rate in lemon sharks. Of 388 sharks that were recaptured, 47 (12.1%) had shed their PIT tag.