Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating the Effect of Delayed Diagnosis on Disease Outcome in Fibromyalgia: A Multi-Center Cross-Sectional Study

Background The impact of delayed diagnosis (DD) on fibromyalgia (FM) patients’ symptomatology and disease outcome has not yet been systematically studied. Objective To analyze the predictors of DD and the influence of DD on FM aggravation and disease evaluation measures. Methods 370 FM patients were interviewed prospectively for this study. The following information was obtained: DD, widespread pain index (WPI), symptom severity scale (SSS), polysymptomatic distress scale (PDS) scale (SSS + WPI), and tender points. We identified three groups of patients: early diagnosis (ED: 2 years; 83 patients), late diagnosis (LD: > 2–7 years; 198 patients), and very late diagnosis (VLD: > 7 years; 89 patients). Results The patients’ average age was 33.9 (9.8) years, and 79% were female. The SSS, PDS, and tender point means were 7.8 (1.6), 16.46 (4.1), and 14.31 (2.3), respectively. The correlation between DD and SSS (r = 0.14), the PDS scale (r = 0.37), and FM tender points (r = 0.16) was significant, but not with WPI (r = 0.06). When the three groups were examined, the SSS mean was 7.54 (1.6), 7.73 (1.4), and 8.25 (1.7), respectively (P 0.008), while the PDS mean was 15 (3.8), 15.95 (3.8), and 18.96 (4.4), respectively (P 0.008). (P 0.001). Conclusion Early FM diagnosis is associated with lower SSS, total severity scale, and FM tender points, indicating a less severe condition.
A Prospective Comparison of Insertion Characteristics of Laryngeal Mask Airway (LMA) ProSeal® Using Rotation Techniques vs Standard Techniques in Adults Undergoing Elective Surgery

Background: Airway management is the most essential skill in Anesthesiology and the inability to secure the airway is one of the most common reasons for anesthesia-related morbidity and mortality. This study aimed to evaluate and compare the insertion characteristics of laryngeal mask airway (LMA) ProSeal insertion using the standard introducer technique, 90-degree rotation technique, and 180-degree rotation technique in adult patients undergoing elective surgery. Material and method: This prospective, interventional, randomized, comparative study was carried out in the Department of Anesthesia and Intensive Care, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, after obtaining hospital ethical committee approval for 18 months of duration. Patients in the age group 18-65 years, of either gender, fulfilling American Society of Anesthesiologists grade I or II criteria, scheduled for elective surgery under general anesthesia with controlled ventilation using the LMA ProSeal were included in the study. The patients were randomized into three groups: Group I - Standard Introducer technique (n=40); Group NR - 90-degree rotation technique (n=40); Group RR - 180-degree rotation technique or back to front (airway) technique (n=40). Result: In this study, the majority (73.3%) of the patients were females with 31 patients in group I, 29 patients in group NR, and 28 patients in group RR. A total of 26.67% of male patients were included in the study. No significant difference in the gender distribution of the three groups was seen in the study. There was no incidence of failure in ProSeal laryngeal mask airway (PLMA) insertion in the NR group, while it was 2.50% in group I and 7.50% in group RR but the difference was not statistically significant. A statistically significant difference was seen in the incidence of LMA ProSeal blood staining (p=0.013). In the post-anesthesia care unit at 1 hour, the incidence of sore throat was 10% in patients with the NR group, 30% in the I group, and 35.44% in the RR group which was statistically significant. Conclusion: The study concluded that the 90-degree rotation technique was superior to both the 180-degree rotation and the introducer technique in adult patients in terms of insertion time, ease of insertion score, manipulation requirement, blood staining of PLMA, and post-op sore throat.
Assessment of the Prevalence and Level of Awareness of Medication Overuse Headache Among the General Population in Makkah City, Saudi Arabia

Background: Medication overuse headache (MOH) is a secondary headache condition caused by consistently using more medication than necessary to treat headache symptoms. MOH is defined as a headache that occurs for 15 or more days per month in a patient with a pre-existing primary headache, and it develops as a result of regular overuse of symptomatic headache medication for more than three months. Patients with headaches often use simple pain medication for 15 or more days per month (e.g., non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol) and 10 or more days per month of opioids, triptans, and combination analgesics, but when there is no relief from these medications, the headache progression can lead to a cycle of consuming more medication with increased pain, which can lead to MOH. Objective: This study aimed to assess the prevalence and awareness of MOH among the general population of Makkah, Saudi Arabia. Methods: A cross-sectional study was conducted between December 2022 and March 2023 using a self-administered online questionnaire disseminated through social media. Data were collected from females and males 18 years of age and older living in Makkah, Saudi Arabia. Results: Overall, 715 individuals completed the questionnaire, 497 of whom were female (69.5%). The average age of the participants was 32.9 years (±13.3 years). The prevalence of MOH among those who reported having experienced headaches throughout their lifetimes was estimated to be 4.5%. Only 134 people (18.7%) were determined to be aware of MOH. Conclusion: This study demonstrated that the general population of Makkah has a high prevalence of MOH and low levels of MOH awareness.
Right Trapezoid Cover for Triangles of Perimeter Two

A convex region covers a family of arcs if it contains a congruent copy of every arc in the family. In 2000, John E. Wetzel determined the smallest rectangle which covers the family of all triangles with perimeter two. In this paper, we search for the smallest right trapezoid which covers the family of all triangles of perimeter two.
Numerical Study of Combustion Induced by Oblique and Conical Shock Waves

A numerical study was carried out for the combustion induced by oblique shock wave over a two-dimensional wedge of finite length. A compressible fluid dynamics code was used with a detailed hydrogen-oxygen combustion mechanism for the numerical study. For an off-attaching condition of oblique detonation waves (ODW) predicted by Rankine-Hugoniot theory with equilibrium chemistry, periodically oscillating combustion was induced by oblique shock wave for certain conditions. Investigation of the numerical results presents that the mechanism of the periodically oscillating combustion is an interaction between shock and reaction waves coupled with chemical kinetic effects. The oscillatory motion at the wedge surface was similar to the periodic motion of one dimensional detonation wave. For the investigation of the criterion of a periodically oscillating combustion, a series of numerical simulations were carried out for wedges of different lengths to change the ratio between fluid dynamic time scale and chemical time scale. At the offattaching condition of ODW predicted by RankineHugoniot theory with equilibrium chemistry, present results reveals three different regimes of combustion. (1) If a fluid dynamic residence time is shorter than a chemical induction time behind an oblique shock wave, combustion may not occur or incomplete shockinduced combustion was observed. (2) If a fluid dynamic residence time is longer than a chemical induction time behind an oblique shock wave, but the former is shorter than the later behind a bow shock wave at same Mach number, oblique shock wave still attaches at the wedge nose, even at the off-attaching condition of oblique detonation waves, and oscillatory combustion was observed. (3) If a fluid dynamic residence time is longer than a chemical induction time behind a bow shock wave, the oblique shock wave is no longer exist and detached bow shock-induced combustion or a detached overdriven detonation wave was observed.
Few‐shot learning for dermatological conditions with Lesion Area Aware Swin Transformer

Skin is the largest organ of the human body and participates in the functional activities of the human body all the time. Therefore, human beings have a large risk of getting skin diseases. The diseased skin lesion image shows visually different characteristics from the normal skin image, and sometimes unusual skin color may indicate human viscera or autoimmune issues. However, the current recognition and classification of dermatological conditions still rely on expert visual diagnosis rather than a visual algorithm. This is because there are many kinds of lesion features of skin diseases, and the lesion accounts for a small proportion of the skin image, so it is difficult to learn the required lesion features; meanwhile, some dermatology images have too few samples to deal with the problem of small samples. In view of the above limitations, we propose a model named Lesion Area Aware Shifted windows Transformer for dermatological conditions classification rely on the powerful performance and excellent result of Swin transformer recently proposed. For brief notation, we use its abbreviation later. Our main contributions are as follows. First, we modify the Swin transformer and use it in the automatic classification of dermatological conditions. Using the self‐attention mechanism of the transformer, our method can mine more long‐distance correlations between diseased tissue image features. Using its shifting windows, we can fuse local features and global features, so it is possible to get better classification results with a flexible receptive field. Second, we use a skip connection to grasp and reinforce global features from the previous block and use Swin transformer to extract detailed local features, which will excavate and merge global features and local features further. Third, considering Swin transformer is a lightweight model compared with traditional transformers, our model is compact for deployment and more favorable to resource‐strict medical devices.
Workarounds as generative mechanisms for bottom‐up process innovation—Insights from a multiple case study

Workarounds are goal‐driven deviations from the standard operating procedures performed to overcome obstacles constraining day‐to‐day work. Despite starting as temporary fixes, they can become established across an organisation and trigger the innovation of processes and IT artefacts that can resolve misfits permanently. Although prior research has elicited antecedents and types of workarounds, it is not known how workarounds diffuse in an organisation and, thereby, innovating co‐workers' activities, IT artefacts, and organisational structures. The results of our multiple two‐year case study provide unique empirical insights into the diffusion of workarounds and how they can act as generative mechanisms for bottom‐up process innovation.
Assimilation of Mode-S EHS Aircraft Observations in COSMO-KENDA

Aircraft observations of wind and temperature collected by airport surveillance radars [Mode-S Enhanced Surveillance (Mode-S EHS)] were assimilated in the Consortium for Small-Scale Modeling Kilometre-scale Ensemble Data Assimilation (COSMO-KENDA), which couples an ensemble Kalman filter to a 40-member ensemble of the convection permitting COSMO-DE model. The number of observing aircrafts in Mode-S EHS was about 15 times larger than in the AMDAR system. In the comparison of both aircraft observation systems, a similar observation error standard deviation was diagnosed for wind. For temperature, a larger error was diagnosed for Mode-S EHS. With the high density of Mode-S EHS observations, a reduction of temperature and wind error in forecasts of 1 and 3 hours was found mainly in the flight level and less near the surface. The amount of Mode-S EHS data was reduced by random thinning to test the effect of a varying observation density. With the current data assimilation setup, a saturation of the forecast error reduction was apparent when more than 50% of the Mode-S EHS data were assimilated. Forecast kinetic energy spectra indicated that the reduction in error is related to analysis updates on all scales resolved by COSMO-DE.
Assessing the Criterion Validity of Curriculum-Based Measures for Children with Intellectual Disabilities

Curriculum-based measures (CBMs), which allow educators to monitor progress over time and make instructional decisions based on student performance, represent a fixture of general approaches to reading and data-based instructional frameworks. However, evidence supporting the use of CBM for students with intellectual disabilities is limited. This study evaluated the criterion validity of a reading CBM battery. Multiple CBM and standardized criterion measures were administered to elementary-age children (N = 56) with intellectual disabilities. Inferential analyses identified numerous domain-specific correlations between CBM and criterion measures; however, no single CBM emerged as a more effective predictor of reading performance. Findings provide qualified support for the use of CBM with children who have intellectual disabilities.
A distribution-free change-point monitoring scheme in high-dimensional settings with application to industrial image surveillance

Existing monitoring tools for multivariate data are often asymptotically distribution-free, computationally intensive, or require a large stretch of stable data. Many of these methods are not applicable to 'high dimension, low sample size' scenarios. With rapid technological advancement, high-dimensional data has become omnipresent in industrial applications. We propose a distribution-free change point monitoring method applicable to high dimensional data. Through an extensive simulation study, performance comparison has been done for different parameter values, under different multivariate distributions with complex dependence structures. The proposed method is robust and efficient in detecting change points under a wide range of shifts in the process distribution. A real-life application illustrated with the help of high-dimensional image surveillance dataset.
Abelian and Tauberian results for the one-dimensional modified Stockwell transforms

The aim of this paper is to study the asymptotic behavior of one- dimensional modified Stockwell transform of a tempered distribution signal through the quasiasymptotic behavior at origin or infinity of the signal itself. More precisely, we give some Abelian results which mean that we derive the asymptotic properties of the S-transform of a tempered signal from the quasiasymptotic properties of the signal itself and we do also the opposite. So, we also give some Tauberian results which describe some quasiasymptotic properties of the tempered signal by means of the asymptotic properties of its Stockwell transform.
Bounds on the Performance of Maximum-Likelihood Decoded Binary Block Codes in AWGN Interference

The error probability of Maximum-Likelihood (ML) soft-decision decoded binary block codes rarely accepts nice closed forms. In addition, for long codes ML decoding becomes prohibitively complex. Nevertheless, bounds on the performance of ML decoded systems provide insight into the effect of system parameters on the overall system performance as well as a measure of efficiency of the suboptimum decoding methods used in practice. In this dissertation, using the so-called Gallager’s first bounding technique (involving a so-called Gallager region) and within the framework of Tangential Sphere Bound (TSB) of Poltyrev, a general bound referred to as the Generalized Tangential Sphere Bound (GTSB) is developed. The Gallager region is chosen to be a general Hyper-Surface of Revolution (HSR) which is optimized to tighten the bound. The search for the optimal Gallager region is a classical problem dating back to Gallager’s thesis in the early 1960’s. For the random coding case, Gallager provided the optimal solution in a closed form while for the non-random case the problem has been an active area of research in information theory for many years. GTSB is applied to two problems. First, to the word error probability of BPSKmodulated binary block codes with ML decoding, and second, to the nonuniform signaling of binary block codes with Maximum-A-Posteriori (MAP) decoding. For both, the optimum HSR is obtained and it is noted that in the former case the resulting bound is the TSB of Poltyrev which has been the tightest bound developed for binary block codes to date. This terminates the search for a better Gallager region in the groundwork of the GTSB for the underlying application. In the development of TSB, union bound which is the simplest inequality from the large class of so-called Bonferroni-type inequalities in probability theory is uti-
Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways

Background Lymphatic metastasis is a common phenomenon of cervical cancer. Tumor necrosis factor-α (TNF-α) was found to be closely associated with lymphatic cancer metastasis. However, the mechanism through which TNF-α regulates lymphatic metastasis in cervical cancer remains unclear. Methods In this study, cervical cancer cells were cultured in Dulbecco's modified Eagle's medium (DMEM) with or without TNF-α for 48 h, and then the corresponding conditional medium (CM-TNF-α or CM) was collected. The level of vascular endothelial growth factor (VEGFC) in the corresponding CM was then detected using an enzyme-linked immunosorbent assay (ELISA). Next, human lymphatic endothelial cells (HLECs) were cultured in CM-TNF-α or CM for 48 h. Cell viability was measured using the cell counting kit-8 (CCK-8) assay, and angiogenesis was detected using a tube formation assay. Subsequently, the expressions of AKT, p-AKT, ERK, and p-ERK in HLECs were detected using western blotting. In addition, to further investigate the effect of TNF-α on the progression of cervical cancer, a C33A subcutaneous xenograft model was established in vivo. Results We found that TNF-α significantly stimulated cervical cancer cells to secrete VEGFC. Additionally, the CM collected from the TNF-α-treated cervical cancer cells notably promoted the proliferation, migration, and angiogenesis of HLECs; however, these changes were reversed by MAZ51, a VEGFR3 inhibitor. Moreover, TNF-α obviously elevated D2-40 and VEGFC protein expressions in tumor tissues, promoting lymphangiogenesis and lymphatic metastasis in vivo. Meanwhile, TNF-α markedly upregulated p-AKT and p-ERK expressions in tumor tissues, whereas these changes were reversed by MAZ51. Conclusion Collectively, TNF-α could promote tumorigenesis, lymphangiogenesis, and lymphatic metastasis in vitro and in vivo in cervical cancer via activating VEGFC-mediated AKT and ERK pathways. These results may provide new directions for the treatment of cervical cancer.
“Murder in mykonos”: potentials and limitations of crime fiction literary tourism in Greece

ABSTRACT Crime fiction literature is enjoyed worldwide for its intriguing mysteries and cultural references depending on the author's nationality or where the narrative takes place. The rising marketing trend of crime fiction literature significantly impacts literary tourism. Famous writers and their works are exploited by destination management organizations and used as a marketing tool; however, this is not happening in Greece. This research explores the sub-niche market of crime fiction literary tourism in Greece and focuses on its potential and limitations. To the best of our knowledge, this research is the first to explore the perspectives of crime fiction authors, publishers, and agents on the subject of crime fiction literary tourism, conducting qualitative research. The results indicate the lack of a national policy in the general market of literary tourism and the lack of understanding concerning the dynamics of crime fiction novels constituting tourism in Greece.
Brazil between global recognition and neutrality over the Russian war against Ukraine

This contribution investigates what explains Brazil's neutrality narrative regarding the Russian war against Ukraine. Brazil's position can be seen as a consequence of the economic interests of Brazilian agrobusiness, but mainly due to its historical tradition of diplomatic neutrality. However, neutrality seems to clash with Brazil's self-conceptualization as being a relevant player at the international level, especially since the 2000s. I show how this identitarian clash has led to an attempt to move from "neutrality" to an "impartiality" discourse, and argue that Brazil might partially align with the West to meet core strategic foreign policy goals.
Antiferromagnetism: the next flagship magnetic order for spintronics ?

Antiferromagnetic materials could represent the future of spintronic applications thanks to the numerous interesting features they combine: they are robust against perturbation due to magnetic fields, produce no stray fields, display ultrafast dynamics and are capable of generating large magneto-transport effects. Intense research efforts over the past decade have been invested in unraveling spin transport properties in antiferromagnetic materials. Whether spin transport can be used to drive the antiferromagnetic order and how subsequent variations can be detected are some of the thrilling challenges currently being addressed. Antiferromagnetic spintronics started out with studies on spin transfer, and has undergone a definite revival in the last few years with the publication of pioneering articles on the use of spin-orbit interactions in antiferromagnets. This paradigm shift offers possibilities for radically new concepts for spin manipulation in electronics. Central to these endeavors are the need for predictive models, relevant disruptive materials and new experimental designs. This paper reviews the most prominent spintronic effects described based on theoretical and experimental analysis of antiferromagnetic materials. It also details some of the remaining bottlenecks and suggests possible avenues for future research.
Non-uniqueness in a nonlinear sharp interface model of cell motility

We consider a system of two coupled parabolic PDEs introduced in [1] to model motility of eukaryotic cells. We study the asymptotic behavior of solutions in the limit of a small parameter related to the width of the interface in phase field function (sharp interface limit). We formally derive an equation of motion of the interface, which is mean curvature motion with an additional nonlinear term. In a 1D model parabolic problem we rigorously justify the sharp interface limit. To this end, a special form of asymptotic expansion is introduced to reduce analysis to a single nonlinear PDE. Further stability analysis reveals a qualitative change in the behavior of the system for small and large values of the coupling parameter. Using numerical simulations we also show discontinuities of the interface velocity and hysteresis. Also, in the 1D case we establish nontrivial traveling waves when the coupling parameter is large enough.