Miracle-dz/UniFAR-FTUs huggingface dataset:
Adipose-derived stromal vascular fraction (SVF) in scar treatment: a systematic review protocol.

BACKGROUND Autologous adipose-derived stromal vascular fraction (SVF) is an emerging therapy that is being pioneered as a potential treatment for keloids and hypertrophic scars. Up to this point, there isn't a cure for keloids and hypertrophic scars yet they comprise the commonest benign skin disorders. Despite published studies reporting potential therapeutic benefits of SVF, their use and efficacy on scar improvement are not clearly described. The aim of this review is to describe the clinical practice involved in harvesting, processing, utilization of SVF, and associated efficacy in scar treatment. METHODS We shall include published clinical articles evaluating the efficacy of SVF on improving scar characteristics and assessment scores among adults with keloids or hypertrophic scars. Article search of Medline/PubMed, Cochrane Library and Embase using Mesh terms of "scars" and "stromal vascular fraction" combined with the Boolean operators ("AND", "OR") will be performed by two independent researchers following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) statement. The primary outcome measure will be the mean difference in the Scar characteristics including Scar assessment scores, scar thickness among others. DATA SYNTHESIS Descriptive data synthesis and mean differences between treatment arms will be calculated for the primary outcome of the scar assessment scores. In case more than three studies provide consistent characteristics of the scar assessment scores, a meta-analysis will be conducted. DISCUSSION Evidence obtained from the systematic review will form the foundation upon which further clinical trials research will be conducted in evaluating the efficacy of autologous adipose-derived stromal vascular fraction in keloid and hypertrophic scar. The systematic review has been submitted to the PROSPERO database and is currently under review.
Globalization and social distance: Multilevel analysis of attitudes toward immigrants in the European Union

Attitudes toward immigrants can, to a large extent, be determined by certain macro contextual factors. This paper tests a number of proposed hypotheses to illustrate patterns of influence generated by economic and social globalization on perceived social distance relative to immigrants. The European Union (EU) constitutes an ideal study case as its Member States vary in exposure to globalization and attract immigrants from different countries of origin. We conduct a multilevel analysis combining individual level variables from Eurobarometer’s recent dataset collected in 2017 and country-level variables from KOF of Globalization Index and other major sources. The results show that individuals in countries with higher degrees of social globalization have lower levels of social distance toward immigrants, while relative level of economic globalization has scant influence. Contact factors are also evaluated for their potential effects. Both casual and close contacts, as specified, reduce social distance. This study contributes to migration studies by offering a clearer specification of how social, rather than economic, globalization interact with contact factors to decrease one’s perceived distance from immigrants in the EU.
Sex difference in trait empathy is encoded in the human anterior insula

Abstract Females are considered the more empathic sex. This conventional view, however, has been challenged in the past few decades with mixed findings. These heterogeneous findings could be caused by the fact that empathy is a complex and multifaceted construct. To clarify whether sex differences exist in certain dimensions of empathy and whether they are associated with specific neural bases, this study measured trait empathy using the interpersonal reactivity index (IRI) and collected brain structural and functional magnetic resonance imaging data in a large sample of healthy participants (206 males vs. 302 females). We found that females scored higher in the personal distress (PD) subscale than males, but they were comparable to males in other IRI subscales. Sex difference in PD was encoded by brain structural (e.g. gray matter volume in left anterior insula [AI]) and functional (e.g. resting-state functional connectivity between left AI and temporoparietal junction/inferior frontal gyrus) characteristics. Notably, the relationship between sex and PD was indirect-only and serially mediated by AI-associated structural and functional characteristics. Altogether, our results suggested that sex difference existed in self-oriented affective empathy (i.e. PD) and highlighted the importance of the AI, both structurally and functionally, in mediating the sex difference in trait empathy.
A randomized control trial on the role of tranexamic acid in preventing intraoperative bleeding during external dacryocystorhinostomy

Purpose: To evaluate the role of tranexamic acid in controlling intra-operative and immediate post-operative bleeding during external dacryocystorhinostomy. Methods: This was a double-blinded randomized placebo-controlled trial. All patients diagnosed with primary acquired nasolacrimal duct obstruction presenting between June 2018 to December 2019 were included in the study. All patients in the study group received a single dose of 1 gm tranexamic acid injection intravenously 30 minutes before the surgery, whereas the patients from group B (placebo) received normal saline. The effect of the injection was measured in terms of duration of the surgery, surgical field grading, amount of total blood loss during the surgery, and the need for postoperative nasal packing. Results: A total of 96 patients were included, of whom 45 were males and 51 were females. The study group (Group A) included 51 patients (27 males and 24 females) and the control group (Group B) included 45 patients (18 males and 27 females). There were no statistically significant differences between the two groups in terms of the duration of surgery (48.43 ± 20.01 minutes vs. 53.38 ± 19.8 minutes, P = 0.228), view of the surgical field (P = 0.084), the amount of intraoperative blood loss (88.63 ± 69.34 mL vs. 88.89 ± 51.93 mL, P = 0.984) and requirement of postoperative nasal packing (54.9% vs 62.2%, P = 0.471). Conclusion: There seems to be little to justify the role of preoperative intravenous tranexamic acid injection in controlling intra-operative and immediate postoperative bleeding during external dacryocystorhinostomy.
Four common vitamin D receptor polymorphisms and coronary artery disease susceptibility: A trial sequential analysis

Background Studies on the susceptibility of vitamin D receptor (VDR) polymorphisms to coronary artery disease (CAD) reached controversial results. We performed this study for a more accurate evaluation between the VDR polymorphisms and CAD susceptibility. Methods PubMed, Embase, CNKI, Wan Fang, and VIP databases were searched. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to evaluate the associations. Trial sequential analysis (TSA) was introduced to estimate the positive associations. The potential functions of the VDR polymorphisms were analyzed based on the SNPinfo and ENSEMBL databases. Results Thirteen studies were finally included. In the overall analysis, increased CAD risks were observed in the VDR rs1544410 polymorphism and verified by the TSA; for the rs2228570 and rs731236 polymorphisms, significant associations with high heterogeneity were detected; decreased risk was remarkably observed for the rs7975232 polymorphism. In the subgroup analysis, wide associations with reduced heterogeneity were observed in the rs2228570, rs1544410, and rs731236 polymorphisms. The RNAfold analysis indicated the mutant G allele of the rs1544410 polymorphism was easier to disperse from the DNA double helix structure and may have a potential crucial role in the VDR transcription process. Conclusions Our analysis supports the role of the rs1544410 polymorphism in the VDR gene as a risk factor for CAD. The VDR rs2228570 and rs731236 polymorphisms were associated with increased CAD risks in the White population. Restrict decreased CAD risk was firstly discovered in the rs7975232 polymorphism. Limitations Firstly, the language was restricted to English and Chinese, which will cause the limited number of studies included; secondly, other unknown polymorphisms in VDR polymorphisms could also be associated the CAD susceptibility, and more case-control studies with comprehensive clinical outcomes and GWAS studies were required; thirdly, the rs1544410, rs7975232 and rs731236 polymorphism are in strong LD, haploid factors with CAD risk need to be considered; fourthly, the mechanisms of the VDR polymorphism on the VDR gene or RNA or protein were not discussed enough, further mechanistic studies are required; at last, genetic factor was the one side for CAD susceptibility, the interaction between environmental risk factors should be considered.
Quantum Process Tomography via L1-norm Minimization

For an initially well designed but imperfect quantum information system, the process matrix is almost sparse in an appropriate basis. Existing theory and associated computational methods (L1-norm minimization) for reconstructing sparse signals establish conditions under which the sparse signal can be perfectly reconstructed from a very limited number of measurements (resources). Although a direct extension to quantum process tomography of the L1-norm minimization theory has not yet emerged, the numerical examples presented here, which apply L1-norm minimization to quantum process tomography, show a significant reduction in resources to achieve a desired estimation accuracy over existing methods.
Phagocytosis of platelets opsonized with differently glycosylated anti-HLA hIgG1 by monocyte-derived macrophages

Abstract Immune-mediated platelet refractoriness (PR) remains a significant problem in the setting of platelet transfusion and is predominantly caused by the presence of alloantibodies directed against class I human leukocyte antigens (HLA). Opsonization of donor platelets with these alloantibodies can result in rapid clearance after transfusion via multiple mechanisms, including antibody dependent cellular phagocytosis (ADCP). Interestingly, not all alloimmunized patients develop PR to unmatched platelet transfusions, suggesting variation in HLA-specific IgG responses between patients. Previously, we observed that the glycosylation profile of anti-HLA antibodies was highly variable between PR patients, especially with respect to Fc galactosylation, sialylation and fucosylation. In the current study, we investigated the effect of different Fc glycosylation patterns, with known effects on complement deposition and FcγR binding, on phagocytosis of opsonized platelets by monocyte-derived human macrophages. We found that the phagocytosis of antibody- and complement-opsonized platelets, by monocyte derived M1 macrophages, was unaffected by these qualitative IgG-glycan differences.
Intravesical BCG and Incidence of Alzheimer Disease in Patients With Bladder Cancer

Introduction: Alzheimer disease (AD) is a common neurodegenerative disease, and immunomodulation offers treatment opportunities. Preclinical data suggest that intravesical Bacillus Calmette-Guerin (BCG) treatment could delay AD development. We investigated this relationship in a population-based cancer database. Sample and Methods: We queried the Surveillance, Epidemiology, and End Results-Medicare database for patients with high-risk nonmuscle-invasive bladder cancer (hrNMIBC). BCG dosage and subsequent Alzheimer diagnosis were collected through ICD-9/10 codes. Multivariable Cox regression was performed to assess the association between BCG therapy and subsequent Alzheimer diagnosis. Results: We identified 26,584 hrNMIBC patients; 51% received BCG and 8.3% were diagnosed with Alzheimer. BCG exposure was significantly associated with lower Alzheimer occurrence (hazard ratio: 0.73, P<0.05), which was dose-dependent. Increasing age, female sex, Black race, and increasing comorbidity index were significantly associated with a greater risk of subsequent Alzheimer diagnosis. Discussion: Treatment with intravesical BCG among patients with hrNMIBC was associated with a significantly lower risk for subsequent Alzheimer diagnosis, which seemed dose-dependent.
Effect of CNT Agglomeration on the Electrical Conductivity and Percolation Threshold of Nanocomposites: A Micromechanics-based Approach

The addition of carbon nanotubes (CNTs) to a matrix material is ex- pected to lead to an increase in the effective electrical properties of nanocompos- ites. However, a CNT entanglement caused by the matrix viscosity and the high aspect ratio of the nanotubes often inhibits the formation of a conductive network. In the present study, the micromechanics-based model is utilized to investigate the effect of CNT agglomeration on the electrical conductivity and percolation thresh- old of nanocomposites. A series of parametric studies considering various shapes and curviness distributions of CNTs are carried out to examine the effects of entan- glement on the electrical performance of nanocomposites. Comparisons between experimental results and the present predictions are made to evaluate the predictive capability of the proposed model. In addition, the present model is incorporated into the commercial finite element software ANSYS HFSS to simulate the electro- magnetic interference (EMI) shielding effectiveness of nanocomposites.
PrEP Demographics and Disparity: The Race, Ethnicity, Gender Identity, Sex Assigned at Birth, Sexual Orientation and Age of Current PrEP Use

ABSTRACT Purpose Identification of disparity in preexposure prophylaxis (PrEP) prescription by demographic group. Design Exploratory descriptive study. Methods Secondary data analysis of 1114 patients who received PrEP from Planned Parenthood League of Massachusetts (PPLM) between 2017 and 2020. Findings Persons of Asian racial-identity had a higher mean PrEP prescription than the other racial groups. Persons over 30 had a higher mean PrEP prescription than those 18–29. Conclusions Discrepancy of PrEP prescription reveals opportunities to improve PrEP delivery. Clinical Evidence Providers of PrEP delivery and community health nurses can enhance delivery by better electronic medical charting regarding PrEP discussion and nonadherence.
Longitudinal effects of prenatal exposure to plastic‐derived chemicals and their metabolites on asthma and lung function from childhood into adulthood

Environmental exposure to phthalates and bisphenol A (BPA), chemicals used in the production of plastics, may increase risk for asthma and allergies. However, little is known about the long‐term effects of early life exposure to these compounds. We investigated if prenatal exposure to these compounds was associated with asthma, allergy and lung function outcomes from early childhood into adulthood in a cohort study.
Theoretical re-evaluations of the black hole mass–bulge mass relation – I. Effect of seed black hole mass

We explore the effect of varying the mass of the seed black hole on the resulting black hole mass - bulge mass relation at z ~ 0, using a semi-analytic model of galaxy formation combined with large cosmological N-body simulations. We constrain our model by requiring the observed properties of galaxies at z ~ 0 are reproduced. In keeping with previous semi-analytic models, we place a seed black hole immediately after a galaxy forms. When the mass of the seed is set at 10^5 M_sun, we find that the model results become inconsistent with recent observational results of the black hole mass - bulge mass relation for dwarf galaxies. In particular, the model predicts that bulges with ~ 10^9 M_sun harbour larger black holes than observed. On the other hand, when we employ seed black holes with 10^3 M_sun, or randomly select their mass within a 10^(3-5) M_sun range, the resulting relation is consistent with observation estimates, including the observed dispersion. We find that to obtain stronger constraints on the mass of seed black holes, observations of less massive bulges at z ~ 0 are a more powerful comparison than the relations at higher redshifts.
The Continuity of Cancer: Children and Adolescent’s Experiences of Ending Cancer Treatment – A Systematic Review

As the research and treatment of childhood cancer steadily progresses, so has the interest in children’s needs, not only throughout such treatment but also following completion. Whilst there is increased literature focussing on the long-term psychosocial impact of treatment completion, little is currently known about how children and young people (CYP) experience the more immediate end of their cancer treatment. The current review seeks to examine CYP’s experiences of the end of their cancer treatment. Sixteen studies were retrieved using a systematic search strategy across five databases, all of which used qualitative methodology. Thematic synthesis was chosen to analyse the data. Four overarching themes were generated, which encompassed ‘the continuity of cancer’, ‘ambivalence of needs’, ‘making sense of the cancer experience’ and ‘sense of self following the ending’. The end of treatment is a time of complexity for CYP, yet it is currently largely overlooked. In order to scaffold these endings for CYP, increased emphasis and thought needs to be placed on the end of treatment and the support that is provided within it.
A MODEL FOR THERMAL PHASE VARIATIONS OF CIRCULAR AND ECCENTRIC EXOPLANETS

We present a semi-analytic model atmosphere for close-in exoplanets that captures the essential physics of phase curves: orbital and viewing geometry, advection, and re-radiation. We calibrate the model with the well-characterized transiting planet, HD 189733b, then compute light curves for seven of the most eccentric transiting planets: Gl 436b, HAT-P-2b, HAT-P-11b, HD 17156b, HD 80606b, WASP-17b, and XO-3b. We present phase variations for a variety of different radiative times and wind speeds. In the limit of instant re-radiation, the light-curve morphology is entirely dictated by the planet's eccentricity and argument of pericenter: the light curve maximum leads or trails the eclipse depending on whether the planet is receding from or approaching the star at superior conjunction, respectively. For a planet with non-zero radiative timescales, the phase peak occurs early for super-rotating winds, and late for sub-rotating winds. We find that for a circular orbit, the timing of the phase variation maximum with respect to superior conjunction indicates the direction of the dominant winds, but cannot break the degeneracy between wind speed and radiative time. For circular planets the phase minimum occurs half an orbit away from the phase maximum—despite the fact that the coolest longitudes are always near the dawn terminator—and therefore does not convey any additional information. In general, increasing the advective frequency or the radiative time has the effect of reducing the peak-to-trough amplitude of phase variations, but there are interesting exceptions to these trends. Lastly, eccentric planets with orbital periods significantly longer than their radiative time exhibit “ringing,” whereby the hot spot generated at periastron rotates in and out of view. The existence of ringing makes it possible to directly measure the wind speed (the frequency of the ringing) and the radiative time constant (the damping of the ringing).
Both brain size and biological sex contribute to variation in white matter microstructure in middle‐aged healthy adults

Whether head size and/or biological sex influence proxies of white matter (WM) microstructure such as fractional anisotropy (FA) and mean diffusivity (MD) remains controversial. Diffusion tensor imaging (DTI) indices are also associated with age, but there are large discrepancies in the spatial distribution and timeline of age‐related differences reported. The aim of this study was to evaluate the associations between intracranial volume (ICV), sex, and age and DTI indices from WM in a population‐based study of healthy individuals (n = 812) aged 50–66 in the Nord‐Trøndelag health survey. Semiautomated tractography and tract‐based spatial statistics (TBSS) analyses were performed on the entire sample and in an ICV‐matched sample of men and women. The tractography results showed a similar positive association between ICV and FA in all major WM tracts in men and women. Associations between ICV and MD, radial diffusivity and axial diffusivity were also found, but to a lesser extent than FA. The TBSS results showed that both men and women had areas of higher and lower FA when controlling for age, but after controlling for age and ICV only women had areas with higher FA. The ICV matched analysis also demonstrated that only women had areas of higher FA. Age was negatively associated with FA across the entire WM skeleton in the TBSS analysis, independent of both sex and ICV. Combined, these findings demonstrated that both ICV and sex contributed to variation in DTI indices and emphasized the importance of considering ICV as a covariate in DTI analysis.
MORPHOLOGY AND DYNAMICS OF THE LOW SOLAR CHROMOSPHERE

The Interferometric Bidimensional Spectrometer (IBIS) installed at the Dunn Solar Telescope of the NSO/SP is used to investigate the morphology and dynamics of the lower chromosphere and the virtually non-magnetic fluctosphere below. The study addresses in particular the structure of magnetic elements that extend into these layers. We choose different quiet-Sun regions inside and outside the coronal holes. In inter-network regions with no significant magnetic flux contributions above the detection limit of IBIS, we find intensity structures with the characteristics of a shock wave pattern. The magnetic flux elements in the network are long lived and seem to resemble the spatially extended counterparts to the underlying photospheric magnetic elements. We suggest a modification to common methods to derive the line-of-sight magnetic field strength and explain some of the difficulties in deriving the magnetic field vector from observations of the fluctosphere.
Knowledge, awareness and attitude of eye donation among non-clinical staff of a tertiary eye hospital in South India

Purpose: This study aimed to evaluate the knowledge, awareness and attitude of eye donation among non-clinical staff of tertiary eye hospitals and to convey a positive attitude toward eye donation by enhancing their awareness and knowledge. Methods: An online cross-sectional study was conducted among the non-clinical staff from all centers of a tertiary eye care hospital across Tamil Nadu. Quiz link was emailed to non-clinical staff of all the centers. On completion of the quiz, the participants viewed their respective scores and the correct answers to all questions. This activity was presumed to subsequently improve their knowledge and clear up the myths on eye donation. Results: Two hundred twenty-eight non-clinical staff from 11 hospitals participated in the quiz. Mean age was 35.3 ± 9.8 years and 130 were female staff (57.05%). One hundred eighty-one participants (79.39%) scored over 50% of the total 17 queries. One hundred eighty-six (81.58%) and 142 (62.28%) participants scored over 50% in the awareness section and knowledge section, respectively. Eye bank volunteers (73, 32.02%) were the main source of information. Twenty-four (10.53%) had already taken pledge for eye donation and 175 (76.75%) were willing to pledge, 29 (12.72%) were not willing to pledge. Twenty-two out of these 29 (75.86%) had no specific reason for not pledging. Family, religious reasons, lack of clarity and fear were least cited reasons (13.79%). Conclusion: Non-clinical staff of an eye hospital are easily approachable and are expected to be more knowledgeable by the general public around them. They might act as primary motivators in raising awareness within their family, friends, relatives and neighbors.