Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Factors for Hypothalamic Obesity in Patients With Adult-Onset Craniopharyngioma: A Consecutive Series of 120 Cases

Context Hypothalamic obesity (HO) is a severe complication following craniopharyngioma, but studies regarding the sequelae in adult-onset patients with craniopharyngioma are sparse. Objective The objective of the study was to describe weight changes after surgical treatment in adult-onset craniopharyngioma patients and to analyze risk factors for postoperative weight gain and HO. Subjects and Method A retrospective analysis was conducted of 120 adult-onset patients who underwent surgery for craniopharyngioma and follow-up at the institution of the authors between January 2018 and September 2020. Clinical characteristics, anthropometric data, image features, treatment modalities, and endocrine indices were collected. Multivariable logistic regression analysis was used to identify independent risk factors for postoperative weight gain and HO. Results Forty-nine (40.8%) patients had clinically meaningful weight gain (≥5%) in a median follow-up time of 12.0 months (range 1.0–41.0 months) after surgery. The mean postoperative weight gain in this subgroup was 17.59 ± 12.28 (%). Weight gain continued in the first year following surgery. Patients with lower preoperative BMI [OR 0.78, 95% CI (0.67–0.90), P = 0.001] and the adamantinomatous subtype [OR 3.46, 95% CI (1.02–11.76), P = 0.047] were more likely to experience postoperative weight gain ≥5%. The prevalence of HO was 19.2% preoperatively and increased to 29.2% at last follow-up postoperatively. Only preoperative BMI [OR 2.51, 95% CI (1.64–3.85), P < 0.001] was identified as an independent risk factor for postoperative HO. Conclusions HO is a common complication in patients with adult-onset craniopharyngioma. Patients with higher preoperative BMI had a greater risk for developing HO postoperatively.
Parent-Child Dyadic Coping and Quality of Life in Chronically Diseased Children

Different forms of dyadic coping are associated with positive outcomes in partner relationships, yet little is known about dyadic coping in parent-child relationships. The current research explored the association between parent-child dyadic coping and children’s quality of life in 12–18-year old children with a chronic disease (i.e., cystic fibrosis, autoimmune diseases, and children post-cancer treatment). In a sample of 105 parent-child dyads, self-reported forms of dyadic coping (i.e., stress communication, problem-oriented, emotion-oriented, and negative dyadic coping) and children’s quality of life were assessed. Children reported more stress communication and negative dyadic coping than their parents, while parents reported more problem-oriented dyadic coping and emotion-oriented dyadic coping than their children. More stress communication of the child was associated with more emotion-oriented dyadic coping and less negative dyadic coping of the parent. More negative dyadic coping of the child was associated with less stress communication, problem-oriented dyadic coping and emotion-oriented dyadic coping of the parent. Additionally, both children’s and parents’ negative dyadic coping were associated with lower self-reported pediatric quality of life and parents’ emotion-oriented dyadic coping was associated with higher pediatric quality of life. These findings emphasize that children and their parents mutually influence each other and that dyadic coping is associated with children’s quality of life. Theoretical and practical implications are discussed.
Porous hollow hydroxyapatite microspheres synthesized by spray pyrolysis using a microalga template: preparation, drug delivery, and bioactivity

Hollow hydroxyapatite microspheres (HHMs) are known to be an excellent drug storage and delivery vehicle. A representative microalga, Chlorella sp. 227, was used as a template to synthesize porous HHMs using spray pyrolysis. This method offers a one-step process for producing HHMs while simultaneously removing the template. As compared to non-HHMs synthesized without microalga, the HHMs described in this paper exhibit 2.7 and 2.2 times greater surface area and pore volume, respectively. The highest drug loading capacity was 0.893 g g−1 for HHMs, which is an improvement of 52% compared to the capacity of non-HHMs. Ibuprofen release was shown to be slower in HHMs, and the release kinetics fit the Higuchi model. This finding suggests that ibuprofen was released via diffusion mechanisms. Immersion in simulated body fluid results in the formation of apatite on the surface of the HHM samples, and the Ca/P ratio is close to the stoichiometric composition. Therefore, HHMs represent an attractive candidate system for sustained drug delivery.
Knowledge, Attitude, and Practice Regarding COVID-19 Among Healthcare Workers in Primary Healthcare Centers in Dubai: A Cross-Sectional Survey, 2020

Introduction: The coronavirus disease 2019 (COVID-19) pandemic continues to challenge healthcare services worldwide. Healthcare workers (HCWs) are key to the continued effort to overcome the pandemic. This study aims to evaluate the knowledge, attitude, and practices of HCWs toward COVID-19 in primary health centers in Dubai. Methods: This cross-sectional study was conducted at four primary health centers in Dubai, including two fever clinics, from July 5th to July 11th, 2020. A self-administered online questionnaire was distributed to nurses and physicians working in these centers, which evaluated their knowledge, attitude, and practices regarding COVID-19 and their associations with the participants' demographic factors. A total score of 80% and above constituted a level of sufficiency in each section. Additionally, Mann-Whitney U test and multivariable logistic regression were used to analyze the variables. Results: A total of 176 HCWs completed the questionnaire, with a 91.2% (176/193) response rate. They were predominantly female (158/176, 90.0%), nurses (128/176, 72.7%), and non-Emiratis (150/176, 85.2%). While official health organizations were the primary source of information for 91.5% (161/176) of participants, only 38.1% (67/176) reported using scientific journals as one of their sources. Overall, 57.4% (101/176) of participants had a sufficient overall level of knowledge. Moreover, knowledge regarding signs, symptoms, and at-risk groups was generally satisfactory. However, knowledge about the virus, testing, transmission, and the isolation of contacts with positive cases was identified correctly by less than two-thirds of the participants. Half of the participants (89/176, 50.6%) expressed their concern about personally acquiring the infection, 112/176 (63.6%) worried about their relatives acquiring it, and 72/176 (40.9%) expressed some hesitancy to take the COVID-19 vaccine once available. Overall, only 58/176 (33.0%) HCWs had a sufficient overall positive attitude score. Nurses, compared to physicians, and non-Emiratis compared to Emiratis' HCWs, had statistically higher mean scores for attitude (U = 2,212, p < 0.01; and U = 1164.5, p < 0.01, respectively). The majority of participants (156/176, 88.6%) reported acceptable infection control practices. Conclusion: Given the gaps identified in the knowledge and attitude, we recommend further training to improve the skills of primary HCWs, with encouragement to practice evidence-based medicine. Additionally, further exploration regarding vaccine hesitancy is warranted.
Pre-mRNA Processing Factors and Retinitis Pigmentosa: RNA Splicing and Beyond

Retinitis pigmentosa (RP) is the most common inherited retinal disease characterized by progressive degeneration of photoreceptors and/or retinal pigment epithelium that eventually results in blindness. Mutations in pre-mRNA processing factors (PRPF3, 4, 6, 8, 31, SNRNP200, and RP9) have been linked to 15–20% of autosomal dominant RP (adRP) cases. Current evidence indicates that PRPF mutations cause retinal specific global spliceosome dysregulation, leading to mis-splicing of numerous genes that are involved in a variety of retina-specific functions and/or general biological processes, including phototransduction, retinol metabolism, photoreceptor disk morphogenesis, retinal cell polarity, ciliogenesis, cytoskeleton and tight junction organization, waste disposal, inflammation, and apoptosis. Importantly, additional PRPF functions beyond RNA splicing have been documented recently, suggesting a more complex mechanism underlying PRPF-RPs driven disease pathogenesis. The current review focuses on the key RP-PRPF genes, depicting the current understanding of their roles in RNA splicing, impact of their mutations on retinal cell’s transcriptome and phenome, discussed in the context of model species including yeast, zebrafish, and mice. Importantly, information on PRPF functions beyond RNA splicing are discussed, aiming at a holistic investigation of PRPF-RP pathogenesis. Finally, work performed in human patient-specific lab models and developing gene and cell-based replacement therapies for the treatment of PRPF-RPs are thoroughly discussed to allow the reader to get a deeper understanding of the disease mechanisms, which we believe will facilitate the establishment of novel and better therapeutic strategies for PRPF-RP patients.
Using Google Street View to Examine Urban Context and Green Amenities in the Global South: The Chilean Experience

This study evaluates the use of virtual, human-interpreted, field observations using Google Street View (GSV) to examine the presence of conditions that may be used to analyze green gentrification in the Global South. We propose that green gentrification is characterized by the introduction or improvement of green amenities (such as parks) as well as corresponding changes to the urban context (such as facade materials). While virtual field observations have been used to examine neighborhood context for other applications, this method has not yet been applied to the study of green gentrification, nor in the Global South. Using one urban park located in Talca, Chile, and in three urban parks located in Santiago, Chile, we sought to address the following research questions: (1) How do in situ and virtual field observations compare as methods of evaluating green amenities and urban context? (2) What characteristics of green amenities and urban context must be addressed to investigate green gentrification in the Global South? (3) How do indicators of green amenities and urban context observed via virtual field observations indicate the potential for green gentrification? In order to observe the streetside conditions of the neighborhoods surrounding established, improved, and new parks, we utilize the ground-level 360° imagery through GSV as an alternative to in situ studies, which can be time-consuming, expensive, and logistically challenging. Features related to the land use composition, building materials used, and the presence of aesthetic improvements and pedestrian amenities were noted as potential indicators of gentrification, and the correspondence between the two methods of observation were evaluated. Results indicate that virtual field observations can provide a promising method that may facilitate the identification and investigation of the effects of green gentrification in the Global South, broadening the scope and application of this research. This comparison offers insight into the use and comparison of virtual and in situ observations for identifying green gentrification in the Global South and for the applicability of the virtual observation method in this heterogeneous urban landscape, especially in cases with unreliable or unavailable data.
High Frequency Occult Hepatitis B Virus Infection Detected in Non-Resolved Donations Suggests the Requirement of Anti-HBc Test in Blood Donors in Southern China

Background Most Chinese Blood Centers adopted mini pool (MP) nucleic acid testing (NAT) for HBV screening due to high cost of Individual donation (ID) NAT, and different proportions of MP-reactive but ID-non-reactive donations (MP+/ID−, defined as non-resolved donations) have been observed during daily donor screening process. Some of these non-resolved donations are occult HBV infections (OBIs), which pose potential risk of HBV transmission if they are not deferred. This study is aimed to further analyze these non-resolved donations. Methods The non-resolved plasma samples were further analyzed by serological tests and various HBV DNA amplification assays including quantitative PCR (qPCR) and nested PCR amplifying the basic core and pre-core promoter regions (BCP/PC; 295 base pairs) and HBsAg (S) region (496 base pairs). Molecular characterizations of HBV DNA+ non-resolved samples were determined by sequencing analysis. Results Of 17,226 MPs from 103,356 seronegative blood donations, 98 MPs were detected reactive for HBV. Fifty-six out of these 98 (57.1%) reactive MPs were resolved as HBV DNA+, but the remaining 42 pools (42.9%, 252 donations) were left non-resolved with a high rate (53.2%) of anti-HBc+. Surprisingly, among 42 non-resolved MPs, 17 contained one donation identified as OBIs by alternative NAT assays. Sequence analysis on HBV DNAs extracted from these OBI donations showed some key mutations in the S region that may lead to failure in HBsAg detection and vaccine escape. Conclusion A total of 53.2% of the non-resolved donations were anti-HBc+, and OBIs were identified in 40.5% of these non-resolved pools. Therefore, non-resolved donations with anti-HBc+ might pose potential risk for HBV transmission. Our present analysis indicates that anti-HBc testing in non-resolved donations should be used to identify OBIs in order to further increase blood safety in China.
PPR-DYW Protein EMP17 Is Required for Mitochondrial RNA Editing, Complex III Biogenesis, and Seed Development in Maize

The conversion of cytidines to uridines (C-to-U) at specific sites in mitochondrial and plastid transcripts is a post-transcriptional processing event that is important to the expression of organellar genes. Pentatricopeptide repeat (PPR) proteins are involved in this process. In this study, we report the function of a previously uncharacterized PPR-DYW protein, Empty pericarp17 (EMP17), in the C-to-U editing and kernel development in maize. EMP17 is targeted to mitochondria. The loss-function of EMP17 arrests maize kernel development, abolishes the editing at ccmFC-799 and nad2-677 sites, and reduces the editing at ccmFC-906 and -966 sites. The absence of editing causes amino acid residue changes in CcmFC-267 (Ser to Pro) and Nad2-226 (Phe to Ser), respectively. As CcmFC functions in cytochrome c (Cytc) maturation, the amount of Cytc and Cytc1 protein is drastically reduced in emp17, suggesting that the CcmFC-267 (Ser to Pro) change impairs the CcmFC function. As a result, the assembly of complex III is strikingly decreased in emp17. In contrast, the assembly of complex I appears less affected, suggesting that the Nad2-226 (Phe to Ser) change may have less impact on Nad2 function. Together, these results indicate that EMP17 is required for the C-to-U editing at several sites in mitochondrial transcripts, complex III biogenesis, and seed development in maize.
Interpersonal Synchrony in the Context of Caregiver-Child Interactions: A Document Co-citation Analysis

Social interactions accompany individuals throughout their whole lives. When examining the underlying mechanisms of social processes, dynamics of synchrony, coordination or attunement emerge between individuals at multiple levels. To identify the impactful publications that studied such mechanisms and establishing the trends that dynamically originated the available literature, the current study adopted a scientometric approach. A sample of 543 documents dated from 1971 to 2021 was derived from Scopus. Subsequently, a document co-citation analysis was conducted on 29,183 cited references to examine the patterns of co-citation among the documents. The resulting network consisted of 1,759 documents connected to each other by 5,011 links. Within the network, five major clusters were identified. The analysis of the content of the three major clusters—namely, “Behavioral synchrony,” “Towards bio-behavioral synchrony,” and “Neural attunement”—suggests an interest in studying attunement in social interactions at multiple levels of analysis, from behavioral to neural, by passing through the level of physiological coordination. Furthermore, although initial studies on synchrony focused mostly on parent-child interactions, new hyperscanning paradigms are allowing researchers to explore the role of biobehavioral synchrony in all social processes in a real-time and ecological fashion. Future potential pathways of research were also discussed.
Marine Debris on New Zealand Beaches - Baseline Data to Evaluate Regional Variances

Terrestrial sources of marine debris on beaches are substantial, increasing, and are primarily a result of mismanaged waste on land. The scale, source, and composition of beached marine debris in New Zealand was determined by surveying 41 beaches, with triplicate belt transects, across the North and South Islands. Results demonstrated a significant spatial variance, with the South Island showing a significantly higher mean density than the more populated North Island by count as well as by weight. The majority of all anthropogenic marine debris detected was plastic and arrived through the water. Explanations for regional variances in debris presence are difficult to ascertain with certainty but could not be explained by population density and proximity. These findings contribute to the understudied field of marine debris research in New Zealand and the Southern Hemisphere and provide a starting point for evidence-based mitigation. Recommended changes to future monitoring programs are made. This first national baseline study of marine debris in New Zealand serves as a reference for follow-up studies, including research at other locations.
Longitudinal Analysis of Dengue Virus–Specific Memory T Cell Responses and Their Association With Clinical Outcome in Subsequent DENV Infection

Memory T cells resulting from primary dengue virus (DENV) infection are hypothesized to influence the clinical outcome of subsequent DENV infection. However, the few studies involving prospectively collected blood samples have found weak and inconsistent associations with outcome and variable temporal trends in DENV-specific memory T cell responses between subjects. This study used both ex-vivo and cultured ELISPOT assays to further evaluate the associations between DENV serotype-cross-reactive memory T cells and severity of secondary infection. Using ex-vivo ELISPOT assays, frequencies of memory T cells secreting IFN-γ in response to DENV structural and non-structural peptide pools were low in PBMC from multiple time points prior to symptomatic secondary DENV infection and showed a variable response to infection. There were no differences in responses between subjects who were not hospitalized (NH, n=6) and those who were hospitalized with dengue hemorrhagic fever (hDHF, n=4). In contrast, responses in cultured ELISPOT assays were more reliably detectable prior to secondary infection and showed more consistent increases after infection. Responses in cultured ELISPOT assays were higher in individuals with hDHF (n=8) compared to NH (n=9) individuals before the secondary infection, with no difference between these groups after infection. These data demonstrate an association of pre-existing DENV-specific memory responses with the severity of illness in subsequent DENV infection, and suggest that frequencies of DENV-reactive T cells measured after short-term culture may be of particular importance for assessing the risk for more severe dengue disease.
Crossed molecular beam study of the reaction O(3P)+C2H4

The reaction between ground state atomic oxygen and ethylene was studied under single collision conditions using the crossed molecular beam method. At an average collision energy of about 6 kcal/mol, the two major primary reaction channels are (a) the formation of CH3 and CHO and (b) the formation of C2H3O and H. Product angular distributions and time‐of‐flight spectra were measured and the translational energy release was determined for each channel. The observed results and calculated potential energy surfaces suggest that after the addition of O(3P) to ethylene forming a triplet diradical, channel (a) occurs by way of intersystem crossing to the singlet state, 1,2‐H migration and subsequent C–C bond rupture, whereas channel (b) proceeds mostly through the direct dissociation of the intermediate triplet diradical, except for a small contribution from H atom elimination of the singlet acetaldehyde intermediate.
When is Char Better Than Subword: A Systematic Study of Segmentation Algorithms for Neural Machine Translation

Subword segmentation algorithms have been a de facto choice when building neural machine translation systems. However, most of them need to learn a segmentation model based on some heuristics, which may produce sub-optimal segmentation. This can be problematic in some scenarios when the target language has rich morphological changes or there is not enough data for learning compact composition rules. Translating at fully character level has the potential to alleviate the issue, but empirical performances of character-based models has not been fully explored. In this paper, we present an in-depth comparison between character-based and subword-based NMT systems under three settings: translating to typologically diverse languages, training with low resource, and adapting to unseen domains. Experiment results show strong competitiveness of character-based models. Further analyses show that compared to subword-based models, character-based models are better at handling morphological phenomena, generating rare and unknown words, and more suitable for transferring to unseen domains.
Zero-shot Event Extraction via Transfer Learning: Challenges and Insights

Event extraction has long been a challenging task, addressed mostly with supervised methods that require expensive annotation and are not extensible to new event ontologies. In this work, we explore the possibility of zero-shot event extraction by formulating it as a set of Textual Entailment (TE) and/or Question Answering (QA) queries (e.g. “A city was attacked” entails “There is an attack”), exploiting pretrained TE/QA models for direct transfer. On ACE-2005 and ERE, our system achieves acceptable results, yet there is still a large gap from supervised approaches, showing that current QA and TE technologies fail in transferring to a different domain. To investigate the reasons behind the gap, we analyze the remaining key challenges, their respective impact, and possible improvement directions.
Risk Minimization for Zero-shot Sequence Labeling

Zero-shot sequence labeling aims to build a sequence labeler without human-annotated datasets. One straightforward approach is utilizing existing systems (source models) to generate pseudo-labeled datasets and train a target sequence labeler accordingly. However, due to the gap between the source and the target languages/domains, this approach may fail to recover the true labels. In this paper, we propose a novel unified framework for zero-shot sequence labeling with minimum risk training and design a new decomposable risk function that models the relations between the predicted labels from the source models and the true labels. By making the risk function trainable, we draw a connection between minimum risk training and latent variable model learning. We propose a unified learning algorithm based on the expectation maximization (EM) algorithm. We extensively evaluate our proposed approaches on cross-lingual/domain sequence labeling tasks over twenty-one datasets. The results show that our approaches outperform state-of-the-art baseline systems.