Miracle-dz/UniFAR-FTUs huggingface dataset:
Synergism of FAK and ROS1 inhibitors in the treatment of CDH1-deficient cancers mediated by FAK-YAP signaling

CDH1 deficiency is common in diffuse gastric cancer and triple negative breast cancer patients, both of which still lack effective therapeutics. ROS1 inhibition results in synthetic lethality in CDH1-deficient cancers, but often leads to adaptive resistance. Here, we demonstrate that upregulation of the FAK activity accompanies the emergence of resistance to ROS1 inhibitor therapy in gastric and breast CDH1-deficient cancers. FAK inhibition, either by FAK inhibitors or by knocking down its expression, resulted in higher cytotoxicity potency of the ROS1 inhibitor in CDH1-deficient cancer cell lines. Co-treatment of mice with the FAK inhibitor and ROS1 inhibitors also showed synergistic effects against CDH1-deficient cancers. Mechanistically, ROS1 inhibitors induce the FAK-YAP-TRX signaling, decreasing oxidative stress-related DNA damage and consequently reducing their anti-cancer effects. The FAK inhibitor suppresses the aberrant FAK-YAP-TRX signaling, reinforcing ROS1 inhibitor's cytotoxicity towards cancer cells. These findings support the use of FAK and ROS1 inhibitors as a combination therapeutic strategy in CDH1-deficient triple negative breast cancer and diffuse gastric cancer patients.
CHEMICAL SIMULATIONS OF PREBIOTIC MOLECULES: INTERSTELLAR ETHANIMINE ISOMERS

The E- and Z-isomers of ethanimine (CH3CHNH) were recently detected toward the star-forming region Sagittarius (Sgr) B2(N) using the Green Bank Telescope PRIMOS cm-wave spectral data, and imaged by the Australia Telescope Compact Array. Ethanimine is not reported in the hot cores of Sgr B2, but only in gas that absorbs at +64 and +82 km s−1 in the foreground of continuum emission generated by H ii regions. The ethanimine isomers can serve as precursors of the amino acid alanine and may play important roles in forming biological molecules in the interstellar medium. Here we present a study of the chemistry of ethanimine using a gas-grain simulation based on rate equations, with both isothermal and warm-up conditions. In addition, the density, kinetic temperature, and cosmic ray ionization rate have been varied. For a variety of physical conditions in the warm-up models for Sgr B2(N) and environs, the simulations show reasonable agreement with observationally obtained abundances. Isothermal models of translucent clouds along the same line of sight yield much lower abundances, so that ethanimine would be much more difficult to detect in these sources despite the fact that other complex molecules have been detected there.
Experimental Study of Air-Cooled Parallel Plate Fin Heat Sinks with and without Circular Pin Fins between the Plate Fins

Experiments were conducted to investigate forced convective cooling performance of an air cooled parallel plate fin heat sink with and without circular pin fins between the plate fins. The original parallel plate heat sink was fabricated consist of 9 parallel plates of length 53 mm with cross-sectional area of 1.4 mm in width by 20 mm height for each plate. The second heat sink has the same geometry of original one but with some circular pins between the plate fins. Thermal and hydrodynamics performances of the heat sinks have been assessed from the results obtained for the pressure drop, thermal resistance and overall performance with the free stream air velocity ranging from 4.7 to 12.5 m/s. Results show that the free stream air velocity has a significant effect on the thermal and hydrodynamics performance of the system. With increasing free stream velocity, the heat transfer coefficient increases and consequently the thermal resistance decreases while pressure drop increases due to higher inertial of fluid at higher velocities. Furthermore, at the same free stream air velocity the thermal resistance for the heat sink with circular pin is about 37.7% lower than that of the original heat sink.
Waste Management Practices and Operational Performance of Hotels in Lagos State, Nigeria

The objective of this study was to determine waste management practices influencing the operational performance of hotels in Lagos State, Nigeria using 120 structured questionnaire that was administered to 20 hotels. Results showed that waste management practices in hotels are very important (3.83), while levels of their operational performance is to a large extent (3.16). Linear Regression showed that waste reduction, reuse and recycling practices (β = 0.383), waste collection and depositing practices (β = 0.413) and waste composting and treatment practices (β = 0.258) significantly (p<0.05) influenced the operational performance of hotels in the study area. The study concluded that waste reduction, reuse, recycling, waste collection, depositing, composting and treatment practices are important contributors in determining the operational performance of hotels. It was recommended that waste management guiding principles, framework and policies be developed and communicated to all stakeholders for proper and effective implementation.
Rapid Transition from a High-Fat, High-Fructose to a Low-Fat, Low-Fructose Diet Reverses Gains in Bone Mass and Strength

ABSTRACT Purpose Obesity is thought to negatively impact bone quality and strength despite improving bone mineral density. We hypothesized that 1) continuous consumption of a high-fat, high-sugar (HFS) diet would impair bone quality and strength, and 2) a change from an HFS diet to a low-fat, low-sugar (LFS) would reverse HFS-induced impairments to bone quality and strength. Methods Six-week-old male C57Bl/6 mice (n = 10/group) with access to a running wheel were randomized to an LFS diet or an HFS diet with simulated sugar-sweetened beverages (20% fructose in place of regular drinking water) for 13 wk. HFS mice were subsequently randomized to continuing HFS feeding (HFS/HFS) or transition to the LFS diet (HFS/LFS) for four additional weeks. Results HFS/HFS mice exhibited superior femoral cancellous microarchitecture (i.e., greater BV/TV, Tb.N, Tb.Th, and decreased Tb.Sp) and cortical bone geometry (i.e., lower Ct.CSA and pMOI) compared with all other groups. At the femoral mid-diaphysis, structural, but not material, mechanical properties were greatest in HFS/HFS mice. However, HFS/HFS exhibited greater femoral neck strength only when compared with mice assigned to diet transition (HFS/LFS). Osteoclast surface and the percentage of osteocytes staining positive for interferon-gamma were greater in HFS/LFS mice, consistent with reduced cancellous microarchitecture postdiet transition. Conclusions HFS feeding enhanced bone anabolism and structural, but not material, mechanical properties in exercising mice. A change from an HFS to LFS diet returned the bone structure to that of continuously LFS-fed mice while compromising strength. Our results indicate rapid weight loss from obese states should be performed with caution to prevent bone fragility. A deeper analysis into the altered bone phenotype in diet-induced obesity from a metabolic standpoint is needed.
Game Techniques in Group Guidance to Improve Post-Covid-19 Interpersonal Communication in Students

The problem arising from the Covid-19 pandemic is the need for more interpersonal communication with students and lecturers. Because educational institutions conduct online learning, students need to communicate properly. , Services are needed to improve student communication To overcome these problems. This study aimed to analyze the influence of Group Guidance Services Using the Games Method on the Improvement of Interpersonal Communication Post-Covid-19 Pandemic Student Guidance and Counseling. This study uses quantitative and experimental research, namely pre-experimental with a one-group pretest-posttest design. The population in this study amounted to 190 people. The sampling was a purposive sampling method with a final sample size of 12 students. The data collection technique uses a Likert scale questionnaire. The data analysis technique used is descriptive analysis and paired sample t-test further test analysis with the help of the SPSS For Windows 20 Version program. The results showed a significant difference between before and after treatment. It was concluded that group guidance services using the game method effectively improved student interpersonal communication.
Molecular Dynamics and Quantum Mechanics Investigation on Mechanic-electric Behaviors of Nanotubes

Singleand multi-wall carbon nanotubes (CNTs) have been found to have wide application in nano-devices and material technology and their behaviors have been intensively studied numerically and experimentally[l,2]. However, the coupled effects of mechanics and electronics and the cyclic behavior of nanotubes which are most important in their application have hardly been investigated. By molecular dynamic (MD) simulation as well as quantum mechanic (QM) study, the coupled effect between mechanical behavior and electronic property are studied extensively.
Anisotropy and Frequency Dependence of Signal Propagation in the Cerebellar Circuit Revealed by High-Density Multielectrode Array Recordings

The cerebellum is one of the most connected structures of the central nervous system and receives inputs over an extended frequency range. Nevertheless, the frequency dependence of cerebellar cortical processing remains elusive. In this work, we characterized cerebellar cortex responsiveness to mossy fibers activation at different frequencies and reconstructed the spread of activity in the sagittal and coronal planes of acute mouse cerebellar slices using a high-throughput high-density multielectrode array (HD-MEA). The enhanced spatiotemporal resolution of HD-MEA revealed the frequency dependence and spatial anisotropy of cerebellar activation. Mossy fiber inputs reached the Purkinje cell layer even at the lowest frequencies, but the efficiency of transmission increased at higher frequencies. These properties, which are likely to descend from the topographic organization of local inhibition, intrinsic electroresponsiveness, and short-term synaptic plasticity, are critical elements that have to be taken into consideration to define the computational properties of the cerebellar cortex and its pathological alterations.
Modeling of Metamaterials in Wave Propagation

Abstract: This chapter focuses on acoustic, electromagnetic, elastic and piezo-electric wave propagation through heterogenous layers. The motivation is provided by the demand for a better understanding of meta-materials and their possible construction. We stress the analogies between the mathematical treatment of phononic, photonic and elastic meta-materials. Moreover, we treat the cloaking problem in more detail from an analytical and simulation oriented point of view. The novelty in the approach presented here is with the interlinked homogenizationand optimization procedure.
Delay‐range‐dependent robust stability and stabilization for uncertain systems with time‐varying delay

This paper concerns delay‐range‐dependent robust stability and stabilization for time‐delay system with linear fractional form uncertainty. The time delay is assumed to be a time‐varying continuous function belonging to a given range. On the basis of a novel Lyapunov–Krasovskii functional, which includes the information of the range, delay‐range‐dependent stability criteria are established in terms of linear matrix inequality. It is shown that the new criteria can provide less conservative results than some existing ones. Moreover, the stability criteria are also used to design the stabilizing state‐feedback controllers. Numerical examples are given to demonstrate the applicability of the proposed approach. Copyright © 2007 John Wiley & Sons, Ltd.
How Ethnic Minority SME Owners in the UK can Create Value Amid Informal Institutional Voids

This article shows that the COVID-19 pandemic exposed informal institutional voids that exist for Black, Asian and Minority Ethnic (BAME) business owners in the United Kingdom. Based on a primary database of surveys and semi-structured interviews, the results show that many BAME small and medium-sized enterprise (SME) owners encountered informal institutional voids that White SME owners did not face during the pandemic. The article also shows how these BAME SME owners created value amid these institutional voids and how they can continue to do so. The article concludes by suggesting that bridging these voids is crucial for promoting a more inclusive environment where ethnic and non-ethnic entrepreneurs can succeed. It also presents policy implications and offers directions for future research.
Frequency of Medication Errors at the University Hospital Center Of Point-G, Mali

Background: Medical errors are considered as a major threat to patient safety. The objective of our study was to describe essential steps in drug circuitry from prescription to administration at the University Hospital Center of Point-G. Methods: We conducted a prospective cross-sectional study design at the University hospital center of Point G from January 30, 2021 to June 30, 2021. We collected data using a Case Report Form (CRF) and reviewed medication order sheets, medication administration records, and patient charts. To identify the independent predictors of medication errors, we analyzed the collected data using Stata version 12. Results: The study included 41 patients with 96 prescriptions with 35 medication errors. The highest error rate was detected in prescription step (15.6%) followed by administration drug step (12.5%) and drug dispensation step (8.3%). The most frequent type of errors was the prescription of wrong drug combination (65.85%) followed by wrong indication (36.58%), wrong treatment duration (12.2%), wrong medication dispensing (15.5%), drug erroneously omitted during dispensation (4.4%), wrong drug delivery during dispensation (64%), wrong route for drug administration (20%) and wrong frequency of administration (12%). These errors did not compromise the health of the patients. Conclusion: Medication errors were common at the University Hospital of Point G involving mainly errors in drug prescription, administration and dispensation.
The Bonferroni and the Scheffé multiple comparison procedures

where b = (X'X)Y'X'y is the least squares estimator of fl. It is easily shown that z is N(6, o_2 V) where V = R (X'X) 'R'. The usual unbiased estimator of o.2 is s2= (y -Xb)'(y -Xb)/(Tk). In situations in which we wish only to decide whether H is true or not we can use a direct test of H such as an F test. It is perhaps more common that when H is rejected we want to know which components of 6 are different from zero and of the non-zero components which are positive and which negative. In this situation we have a multiple decision problem and a natural solution is to use an induced test. As an example suppose in the case q = 2 that we wish to test the hypothesis H: 01 =02 = 0. Since H is true if and only if the separate hypotheses H1: 01 = 0 and H2: 02= 0 are both true, this suggests a sequence of separate tests which will induce a test of H. Testing the two hypotheses H1 and H2 where we are interested in whether 01 or 62 or both are different from zero induces a multiple decision problem in which the four possible decisions are
Results of the deepest all-sky survey for continuous gravitational waves on LIGO S6 data running on the Einstein@Home volunteer distributed computing project

We report results of a deep all-sky search for periodic gravitational waves from isolated neutron stars in data from the S6 LIGO science run. The search was possible thanks to the computing power provided by the volunteers of the Einstein@Home distributed computing project. We find no significant signal candidate and set the most stringent upper limits to date on the amplitude of gravitational wave signals from the target population. At the frequency of best strain sensitivity, between $170.5$ and $171$ Hz we set a 90% confidence upper limit of ${5.5}^{-25}$, while at the high end of our frequency range, around 505 Hz, we achieve upper limits $\simeq {10}^{-24}$. At $230$ Hz we can exclude sources with ellipticities greater than $10^{-6}$ within 100 pc of Earth with fiducial value of the principal moment of inertia of $10^{38} \textrm{kg m}^2$. If we assume a higher (lower) gravitational wave spindown we constrain farther (closer) objects to higher (lower) ellipticities.
Arranging Golden Goodbyes for Executive Exits: A Review and Agenda for Severance Pay

While firms compensate executives in many ways, severance pay is perhaps the most controversial yet least understood form of executive compensation. In this study, we outline a review and agenda for severance pay owed if an executive is dismissed without cause from their role. Following changes to the disclosure of executive compensation in 2006, researchers have taken a renewed interest in studying executive severance pay. The current literature on this topic, however, has evolved along loosely connected research streams across multiple disciplines. This lack of integration presents a challenge for management scholars seeking to advance our knowledge of this important form of compensation. To address this issue, we provide an interdisciplinary review, incorporating recent studies that have taken advantage of the increased transparency of severance pay. Our review clarifies key differences between severance and other forms of executive pay and organizes prior studies along three main areas of research to draw conclusions about the current literature on this form of compensation. We also outline an agenda for future research, drawing upon several literatures that are key to management research—agency theory, managerial power theory, upper echelons theory, stakeholder theory, impression management theory, and the executive labor market. By integrating perspectives that, while less common in related fields, are central to management research, we provide unique insights for future research. Finally, we discuss key methodological issues, including data accuracy, measurement consistency, and analytical approaches, and how these can be addressed moving forward.
Levocetirizine-Loaded Electrospun Fibers from Water-Soluble Polymers: Encapsulation and Drug Release

Electrospun fibers containing levocetirizine, a BCS III drug, were prepared from three water-soluble polymers, hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA). Fiber-spinning technology was optimized for each polymer separately. The polymers contained 10 wt% of the active component. An amorphous drug was homogeneously distributed within the fibers. The solubility of the drug in the polymers used was limited, with a maximum of 2.0 wt%, but it was very large in most of the solvents used for fiber spinning and in the dissolution media. The thickness of the fibers was uniform and the presence of the drug basically did not influence it at all. The fiber diameters were in the same range, although somewhat thinner fibers could be prepared from PVA than from the other two polymers. The results showed that the drug was amorphous in the fibers. Most of the drug was located within the fibers, probably as a separate phase; the encapsulation efficiency proved to be 80–90%. The kinetics of the drug release were evaluated quantitatively by the Noyes–Whitney model. The released drug was approximately the same for all the polymers under all conditions (pH), and it changed somewhere between 80 and 100%. The release rate depended both on the type of polymer and pH and varied between 0.1 and 0.9 min−1. Consequently, the selection of the carrier polymer allowed for the adjustment of the release rate according to the requirements, thus justifying the use of electrospun fibers as carrier materials for levocetirizine.
A Plaque-Like CD34-Positive Dermal Fibroma Presenting as an Acquired Papule

CD34-positive dermal fibromas (PDFs) are cutaneous neoplasms that display a characteristic pattern of superficial dermal spindle cell proliferation on histopathology evaluation. They are clinically heterogenous in presentation and thought to follow a benign course. CD34-PDFs have features that overlap with dermatofibrosarcoma protuberans (DFSP), a locally aggressive low-grade superficial sarcoma. Cytogenetic studies are essential to distinguish the two. This report presents the case of a 38-year-old female with a CD34-PDF on the right antecubital fossa.
A two locus haploid population with overlapping generations.

The rates and probabilities of fixation in pure homozygous states are obtained for a finite size, two linked loci population of monoecious haploid individuals (e.g. bacteria) reproducing by mechanisms that may be loosely termed random and nonrandom matings. Birth-death events occur one at a time so that the generations are overlapping. It is foulnd that the degree of nonrandom mating does not affect the fixatioii probabilities and, indeed, these probabilities are identical to the fixation probabilities for a certain discrete generations model well known in the literature. Furthermore, if N birth-death events of the overlapping generations model are identified with one discrete generation and the nonrandom mating condition is dropped, then this rate is asymptotically equal to the known rate. The rate of approach to fixation of the first allele to be fixed is found exactly for all population sizes when the recombination fraction is at its extreme values. This rate is also determined numerically for certain small population sizes and specific values of the recombination fraction. It appears that this rate is made quicker by increasing the valtue of recombination fraction and that for large population sizes there exists a critical value of the recombination fraction after which the rate is effectively constant.
Bankruptcy Prediction for Micro and Small Enterprises Using Financial, Non-Financial, Business Sector and Macroeconomic Variables: The Case of the Lithuanian Construction Sector

Credit-risk models that are designed for general application across sectors may not be suitable for the construction industry, which has unique characteristics and financial risks that require specialised modelling approaches. Moreover, advanced bankruptcy-prediction models are often used to achieve the highest accuracy in large modern datasets. Therefore, the aim of this research is the creation of enterprise-bankruptcy prediction (EBP) models for Lithuanian micro and small enterprises (MiSEs) in the construction sector. This issue is analysed based on classification models and the specific types of variable used. Firstly, four types of variable are proposed. In EBP models, financial variables substantially explain an enterprise’s financial statements and performance from different perspectives. Including enterprises’ non-financial, construction-sector and macroeconomic variables improves the characteristics of EBP models. The inclusion of macroeconomic variables in the model has a particularly significant impact. These findings can be of great significance to investors, creditors, policymakers and practitioners in assessing financial risks and making informed decisions. The second question is related to the classification models used. To develop the EBP models, logistic regression (LR), artificial neural networks (ANNs) and multivariate adaptive regression splines (MARS) were used. In addition, this study developed two-stage hybrid models, i.e., the LR is combined with ANNs. The findings show that two‑stage hybrid models do not improve bankruptcy prediction. It cannot be argued that ANN models are more accurate in predicting bankruptcy. The MARS model demonstrates the best bankruptcy prediction, i.e., this model could be a valuable tool for stakeholders to evaluate enterprises’ financial risk.