Miracle-dz/UniFAR-FTUs huggingface dataset:
Inflamação, inflamassoma e desregulação epigenética na patogênese e evolução de neoplasias hematológicas medulares = Inflammation,inflammasomes and epigenetic dysregulation in the pathogenesis and evolution of bone marrow malignancies

O nicho hematopoetico e um microambiente fisiologico especifico com a funcao primordial de manter a pluripotencialidade, a capacidade de autorrenovacao e a quiescencia das celulas precursoras hematopoeticas. As neoplasias hematologicas medulares tem origem mieloide ou linfoide e sao capazes de subverter o nicho hematopoetico, criando relacoes patologicas com as celulas deste microambiente e estabelecendo o "nicho neoplasico". Os objetivos gerais do trabalho foram divididos em duas partes: (1) investigar o papel da via inflamatoria inflamassoma e da via de autofagia em pacientes com mieloma multiplo e outras gamopatias monoclonais e (2) o papel do inibidor de reparo de dano ao DNA, BRD4, na biologia das sindromes mielodisplasicas. No mieloma multiplo, observamos que a presenca de plasmocitos circulantes foi um fator independente de pior sobrevida dos pacientes com gamopatias monoclonais de nossa coorte e que ocorre a ativacao da via de autofagia na medula ossea dos pacientes de modo proporcional a quantidade de plasmocitos. Quanto ao inflamassoma, houve ativacao do mediador caspase 1 e da proteina adaptora ASC, indicando uma inducao de sinal tipo 1 na medula dos pacientes com gamopatias. Por fim, a maior expressao genica ao diagnostico do mediador da via NLRP3 na medula ossea dos pacientes foi preditor de melhor resposta ao tratamento com talidomida, indicando seu potencial papel como biomarcardor de resposta terapeutica. Nas sindromes mielodisplasicas, observamos um aumento de expressao do transcrito variante curto do gene BRD4 e este transcrito se mostrou uma variavel independente de pior prognostico, juntamente com o escore prognostico R-IPSS. Estudos celulares com linhagens leucemicas mostraram que a inibicao farmacologica do BRD4 ou o silenciamento genico resultaram no aumento da fosforilacao da histona H2AX da via de reparo de dano ao DNA, causando ativacao da apoptose em linhagens leucemicas. Da mesma forma, a inibicao do BRD4 em linhagem leucemica apresentou efeito aditivo ao tratamento com o agente hipometilante azacitidina na inducao de apoptose. Coletivamente, os nossos resultados comprovam a presenca de desregulacoes inflamatorias e epigeneticas nas neoplasias hematologicas medulares estudadas e indicam possiveis oportunidades terapeuticas da manipulacao dessas vias. Abstract
The Price and Quantity of Interest Rate Risk

Studies of the dynamics of bond risk premia that do not account for the corresponding dynamics of bond risk are hard to interpret. We propose a new approach to modeling bond risk and risk premia. For each of the US and China, we reduce the government bond market to its first two principal-component bond-factor portfolios. For each bond-factor portfolio, we estimate the joint dynamics of its volatility and Sharpe ratio as functions of yield curve variables, and of VIX in the US. We have three main findings. (1) There is an important second factor in bond risk premia. (2) Time variation in bond return volatility is as important as time variation in bond Sharpe ratios. (3) Bond risk premia are solely compensation for bond risk, as no-arbitrage theory predicts. Our approach also allows us to document interesting cyclical and secular time-variation in the term structure of bond risk premia in both the US and China.
Gel-forming characteristics of surimi from white croaker under the inhibition of the polymerization and degradation of protein.

The aim of this study is to investigate gel-forming characteristics of white croaker protein itself. This study was carried out under the inhibition of the polymerization and degradation of myosin heavy chain (MHC) by ethylenediaminetetraacetic acid and leupeptin. The heat-induced gels were prepared by preheating at temperatures in the range of 30-80°C for 20 min or 2 h and then heating at 80°C for 20 min and were evaluated in terms of gel strength. In order to investigate the behavior of proteins, sodium dodecyl sulfate-polyacrylamide gel electrophoresis was carried out. Folin method was used to clarify the degradation of proteins by protease. Suwari occurred during preheating at 40 and 50°C and it contributed to gel-strengthening effect of the 2-step heating gels preheated at 50°C, indicating that non-covalent bonding reinforced the gel during setting and subsequent heating at 80°C even under the inhibition of the polymerization and degradation of MHC. The gel strength of 2-step heating gels was not affected by preheating temperature for 20 min, except for the gel preheated at 50°C under the inhibitory condition. Those gel strength values were similar to that of the gel heated directly at 80°C for 20 min. The maximum gel strength was obtained at 50°C. This suggests the gelforming ability of white croaker protein itself. At temperature above 60°C, the gel strength decreased with preheating time, though the degradation of MHC was suppressed, indicating that non-proteolytic modori contributes to the weakening of gel of white croaker surimi.
Additional Rb‐Sr and single‐grain zircon datings of Caledonian granitoid rocks from Albert I Land, northwest Spitsbergen

Previous K-Ar and Rb-Sr datings of the metamorphic and granitic rocks from the northwestern basement region of Spitsbergen mainly show the cooling time of the rocks, except for a Rb-Sr isochron age of the Hornemantoppen granitoid. New samples were collected during several years of geological mapping in the area and the Rb-Sr whole rock isochron and single-grain zircon evaporation methods were applied to the Hornemantoppen granitoids and the grey granites. A dioritic dyke was also dated by the latter method. The bulk rock chemistry study shows that most of both granitic rocks are of the S-type and probably post orogenic, with distinctive incorporation of crustal materials. The isotopic data also support this interpretation. The results of the Rb-Sr isotope analyses, 412 ± 4.8 Ma and the zircon Pb evaporation age of 424 ± 56 Ma, confirm the previous age of the Hornemantoppen granitoid, 414 ± 10 Ma. An older zircon age of 547 ± 19 Ma is considered to be the minimum age of inherited zircon. Zircons from the grey granites suggest an age of ca. 420 Ma with a large error. Field relations demonstrate that the grey granites are older than the Hornemantoppen granitoids. A minimum inherited zircon age, 952 ± 20 Ma, has been obtained from the grey granites. Three multi-grain Pb ages, 423 ± 22 Ma (2 grains), 461 ± 42 Ma and 561 ± 93 Ma (the last two 3 grains) were considered to be mixed ages. Although no definitive evidence for the presence of Grenvillian granites in this area has been obtained in the present study, preliminary results from the multi-grain zircon evaporation method, carried out in the Russian laboratory at Apatity, infer Paleo- and Mesoproterozoic protoliths for the metamorphic rocks of northwestern Spitsbergen.
Factors affecting life-history parameters of the pine beauty moth, Panolis flammea (D&S): the hidden costs of reproduction

Egg-laying rates of female Panolis flammea (D&S) were greater on some provenances of Lodgepole pine (Pinus contorta Douglas) than others. The shorter the pre-reproductive delay, the greater the number of eggs that was laid. Egg weights were negatively correlated with the total and daily number of eggs laid. Eggs laid on hosts affording good nutrition for larval growth were smaller than eggs laid on poor hosts. The life span of fed moths was greatest on those hosts that also gave the greatest oviposition rate. Lifespan and fecundity were not correlated with adult weight. These results are discussed in relation to current life-history theories. Key-words: Panolis flammea, oviposition, life span, reproductive costs, longevity, Pinus contorta
Survival and natal dispersal of fledglings of Tengmalm's owl in relation to fluctuating food conditions and hatching date

(1) 4311 fledglings of Tengmalm's owl were ringed during 1964-85 in western Finland: 53 (1-2%) were later recovered after surviving at least the first winter. (2) The proportion of fledglings which were recovered was significantly larger in the increase phase of the vole cycle than in the peak, decrease and low phases. The numbers of fledglings produced were larger in the increase and peak phases than in the decrease and low phases. Thus, the number of fledglings surviving in the increase phase was twice as large as that in the other phases. There were no differences in the distances of natal dispersal between the four phases of the vole cycle. (3) Hatching date within the season did not seem to affect survival. Because early clutches produced more fledglings than late ones, clutches hatched in April produced 1-5 times as many surviving young as those hatched in May-July. Distances of natal dispersal of early and late young were nearly similar. (4) Food conditions during the post-fledging and independence periods seemed to be crucial for the survival of the young. Because vole cycles are fairly predictable, a selective advantage could be expected for those owls that invest most in reproduction during the increase phase, the contribution to the future gene pool of the population being highest at that time. (5) Because the survival of the young varies in the course of the vole cycle, the reproductive value of an egg depends both on laying date and food supply.
Sedenions , the Clifford algebra C ` ( 8 ) , and three fermion generations

Recently there has been renewed interest in using tensor products of division algebras, together with their associated Clifford algebras, to identify the structures of the Standard Model. One full generations of leptons and quarks transforming correctly under the electrocolor group SU(3)c⊗ U(1)em can be described in terms of complex octonion algebra C⊗O. By going beyond the division algebras, and considering the larger Cayley-Dickson algebra of sedenions S, this one generation model is extended to exactly three generations. Each generation is contained in an C⊗O subalgebra of C⊗S, however these three subalgebras are not independent of one another. This three generation model can be related to an alternative model of three generations based on the exceptional Jordan algebra J3(O). It is speculated that the shared C⊗H algebra common to all three generations might form a basis for CKM mixing.
AI and Jobs: Evidence from Online Vacancies

We study the impact of AI on labor markets, using establishment level data on vacancies with detailed occupational information comprising the near-universe of online vacancies in the US from 2010 onwards. We classify establishments as “AI exposed” when their workers engage in tasks that are compatible with current AI capabilities. We document rapid growth in AI related vacancies over 2010-2018 that is not limited to the Professional and Business Services and Information Technology sectors and is significantly greater in AI-exposed establishments. AI-exposed establishments are differentially eliminating vacancy postings that list a range of previously-posted skills while simultaneously posting skill requirements that were not previously listed. Establishment-level estimates suggest that AI-exposed establishments are reducing hiring in non-AI positions even as they expand AI hiring. However, we find no discernible impact of AI exposure on employment or wages at the occupation or industry level, implying that AI is currently substituting for humans in a subset of tasks but it is not yet having detectable aggregate labor market consequences.
Institutional factors and subnational location choice for multinationals’ R&D subsidiaries

Purpose Using an institution-based view, this study aims to conceptualize how sub-national institutional characteristics are likely to explain location choice of multinationals’ research and development (R&D) subsidiaries. Design/methodology/approach In a conceptual paper, this study explores specific institutional facets of the regional environments within a country that are capable of explaining, at least in part, the location choices of multinational corporations’ R&D subsidiaries. Findings This study thus explores the more nuanced influences of the institutional environments at a subnational level and develops propositions to explain location choices based on the differences of the institutional environments. Originality/value This study contributes to international business theory by incorporating a location-specific analysis that contrasts to the usual country-level observation on the determinants of firms’ location decisions.
THE IMPACT OF HEN HARRIERS ON RED GROUSE BREEDING SUCCESS

(1) The effect of predation by hen harrier (Circus cyaneus L.) on the breeding success of red grouse (Lagopus lagopus scoticus Lath.) was examined on managed moorland in Scotland. (2) Extensive studies of breeding success on pairs of moors indicated that moors with breeding harriers produced an average of 17% fewer young grouse. On one pair of moors losses varied positively with harrier density over 3 years. (3) On intensive study areas, grouse brood size was measured 2 weeks after hatching and 6 weeks later. Harriers were observed hunting during this period and a figure for expected chick losses obtained. Over the 3 years harrier predation accounted for 91% of observed losses in the 6 weeks. (4) Prey was examined at three harrier nests in 1988. Of 299 items identified, 32% were grouse chicks, although there were significant differences among nests. (5) Data from this and other studies of hen harrier diet were collated. The relationship between grouse density and the proportion of grouse in the harrier diet indicated that grouse populations at low density are most vulnerable to high chick losses.
BART for Knowledge Grounded Conversations

Transformers have shown incredible capabilities for conversation modeling, however, they store factual knowledge in their learned parameters, which is costly to update with new knowledge since it requires retraining Models trained before the Coronavirus pandemic do not know about COVID-19 In this paper, we investigate how a BART model can be adapted to a knowledge grounded conversational setup We introduce the notion of key and query tokens to retrieve knowledge stored in an external database, that can easily be updated with new knowledge As factual knowledge can hardly be reduced to a single sentence or vector, we allow the model to retrieve multiple sentences from the memory Our analysis shows perplexity decreases with the number of passages retrieved from memory Second, our analysis shows a shared encoder for knowledge retrieval, and conversation understanding reduces the model size and perform as well as a specialized module © 2020 Copyright held by the owner/author(s)
POLLUTION LOAD INDEX (PLI), A YARDSTICK FOR ASSESSING THE QUALITY OF WATER IN SHIKA DAM

Eleven sampling sites along Shika Dam, Sabongari LGA, Kaduna State, Nigeria were chosen to collect and assess the levels of As, Cr, Ni, Pb, Co and Cd in the dam water using pollution load index (PLI). Results of the Metal analysis revealed that Cd and As present in the water were above the permissible limits of WHO and FAO, respectively. This clearly showed that the water is highly polluted with respect to these metals. However, the levels of Cr, Pb, and Ni detected in the samples were below the WHO permissible limits of 0.1, 0.05, and 0.05 mg/L, respectively. The Cr, Pb and Ni detected permissible limits across the Dam. The physico-chemical parameters that were analyzed include: DO, BOD, COD, Turbidity, TSS, Colour, EC, pH, NO  3 –N, PO  3
Assessment of Community Knowledge, Attitude, and Practice on Milk Borne Zoonotic Diseases in Jinka, Southern Ethiopia

A cross-sectional study has been conducted in Jinka Town to assess the knowledge, attitude, and practices of the community on milk-borne Zoonotic diseases. As a result, a total of 395 study participants from the different socio-demographic backgrounds were randomly selected and voluntarily filled out the semistructured questionnaire which was distributed to gather the required information from the respondents. The findings show that 60.51% of the respondents knew that milk born zoonotic diseases could be acquired through the consumption of raw milk whereas 36.96% of the respondents prefer to consume unpasteurized milk. Of the total respondents, 34.94 % still have no idea about the preventive measures of milk born zoonotic diseases. 74.94% of respondents in this study did not receive formal training on milk-borne zoonotic diseases. Statistically, there was a strong association of respondents on milk-borne zoonosis (p<0.05) between the educational level and KAP. About (11.90 %) of the respondents shared the same house with the animals. Besides, around (36.96%) of respondents were accustomed to using the raw milk, and about (36.71%) were habitual in giving the children raw milk. According to the study, the overall knowledge, attitude, and practice of milk-borne zoonotic diseases in the study site is not adequate. Thus, community education and awareness-raising programs are therefore needed to further improve the community’s knowledge, attitude, and practice on milk-borne zoonotic diseases. *Corresponding author Haben Fesseha, School of Veterinary Medicine, Wolaita Sodo University, P.O. Box 138, Wolaita Sodo, Ethiopia, Email: tseyon.h@mail.com Submitted: 18 August 2020 Accepted: 14 September 2020 Published: 18 September 2020 Copyright © 2020 Abebe F, et al.
Measurement of the *--> and *--> transition form factors

We study the reactions e þ e (cid:2) ! e þ e (cid:2) (cid:1) ð0Þ in the single-tag mode and measure the (cid:2)(cid:2) (cid:1) ! (cid:1) ð0Þ transition form factors in the momentum-transfer range from 4 to 40 GeV 2 . The analysis is based on 469 fb (cid:2) 1 of integrated luminosity collected at PEP-II with the BABAR detector at e þ e (cid:2)
Changing anisotropy of G0 in Hostun sand during drained monotonic and cyclic loading

The inherent and stress-induced anisotropy of saturated Hostun sand has been examined by means of shear wave velocity measurements under drained monotonic and cyclic triaxial conditions. Tests were carried out on samples prepared by moist tamping for a wide range of initial densities in a fully instrumented stress-path triaxial apparatus equipped with bender element instrumentation in three directions. Data have been normalised to account for the variations in void ratio and mean effective stress. The evolution of shear stiffness under anisotropic stress conditions has been explored by performing both constant mean effective stress tests and constant radial stress tests in compression and extension. Some samples were subsequently subjected to multiple drained deviatoric loading cycles, and the evolution of shear stiffness was examined. The tests showed that the initial inherent anisotropy was small, namely, lower than that previously observed in dry pluviated samples of the same sand in a cubical cell apparatus. Changing stress levels in compression or extension resulted in stress-induced anisotropy even when there were no changes in the values for p′, indicating that the widely-used empirical expressions for G0 under isotropic stress states are not strictly applicable under anisotropic stress conditions. The comparison between stress-induced anisotropy in compression and in extension is discussed, and the evolution of shear stiffness during drained cyclic loading is examined. It is concluded that the changes in inherent anisotropy during these tests were small, but that new constitutive models should account for such changes in state with appropriate normalization. & 2015 The Japanese Geotechnical Society. Production and hosting by Elsevier B.V. All rights reserved.
Regulation of Flowering and Fruit Quality in Pineapple cv. Kew (Ananas comosus Merr.) Grown as Intercrops in Guava Orchard

The pineapple is one of the most edible fruit crops of the family Bromeliaceae which embraces about 2,000 species, mostly epiphytic and ornamental. It is known as Ananas comosus Merr. (Morton 1987). The pineapple fruit has acquired few vernacular names like pinaby Spanish-speaking people, abacaxi in the Portuguese tongue, ananas by the Dutch and French and Asians (Paull and Duarte 2010, Elzibroek and Wind 2008). In International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 8 (2020) Journal homepage: http://www.ijcmas. com
EFFECT OF INTROGRESSION ON THE SERPENTINE ENDEMISM OF QUERCUS DURATA

Quercus durata Jepson, the leather oak, and Q. dumosa Nutt. , the scrub oak, are common species of chaparral and woodland on dry slopes of the Coast Ranges of Northern California. They are closely related evergreen shrubs differing mainly in details of pubescence, toothing, and marginal recurvature of the leaves. The two species do not occur in mixed populations, for Q. durata is normally found only on serpentine soils in which Q. dumosa is apparently unable to succeed. One usually replaces the other rather abruptly where serpentine outcrops, but the scattering of hybrid individuals sometimes found in the transitional zone indicates that the species are not reproductively isolated. A measure of seasonal isolation is provided by a difference of a few weeks in flowering time, but the very strong edaphic separation is probably sufficient on its own to prevent substantial introgression and blurring. In February 1960 a variable population of shrubby oaks combining characteristics of both Q. durata and Q. dumosa was discovered on top of the ridge north of Mt. Vaca, on the boundary of Napa and Solano Counties. It appeared to be separated rather sharply from the brush containing Q. dumosa on the surrounding slopes and canyons, but there was no indication that the soil had been derived from serpentine. The nearest occurrence of Q. durata is on a number of serpentine outcrops some four miles to the northwest, so the origin and nature of this apparent hybrid population seemed worthy of investigation. Accordingly specimens of the plants were collected and compared in detail with typical Q. durata and Q. dumosa, and the soils on the ridgetop tested for properties characteristic of serpentine soils.
Epidemiology, pathophysiology, and pathogenesis of cryptorchidism. Evaluation and treatment of undescended testicle

Cryptorchidism – the absence of one or both testes in the normal scrotal position – is the most common birth defect of the male genitalia. In full-term newborn boys its incidence is estimated at 2–5%. During the first three months of life, in half of these boys the testicles will descend spontaneously into the scrotum, but at the end of the first year of life 1% of boys will have cryptorchidism. Among boys born prematurely, about 30% of them have undescended testicles at birth, but also in such cases approximately 80% of undescended testes descend by the third month of life. The authors discuss the epidemiology, pathophysiology, aetiology, and treatment of undescended testicle in boys.
Aggregation Indices of Cotton Arthropods in Texas

Two indices were used to quantify the aggregation of cotton arthropods: the parameter K of the negative binomial distribution and Morisita's index of dispersion I δ. Using frequency distribution data the average values of these indices were calculated. In general there was close agreement between K and I δ. Cotton fleahopper, Pseudatomoscelis seriatus (Rueter), nymphs were more aggregated than fleahopper adults. A greater degree of aggregation was observed for boll weevil, Anthonomus grandis Boheman, eggs than for boll weevil adults. Bollworm, Heliothis zea (Boddie), and tobacco budworm, H. virescens (F.), eggs exhibited more aggregation than Heliothis spp. larvae. Aggregation continued to decrease as the Heliothis spp. larvae became full grown. Among the predatory cotton arthropods, lady beetles and minute flower bugs, Orius spp. , displayed the greatest amount of aggregation. Big-eyed bugs, Geocoris spp. , were less aggregated and the spatial distributions of spiders were the least aggregated of the predatory arthropods.