Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study

Aim To analyze the effectiveness and safety of hydrogen inhalation (HI) therapy as an adjunct treatment in Chinese type 2 diabetes mellitus (T2DM) patients in a real-life clinical setting. Methods This observational, non-interventional, retrospective, double-arm, 6-month clinical study included T2DM patients receiving conventional anti-diabetes medication with or without HI initiation from 2018 to 2021. Patients were assigned to the HI group or non-HI group (control group) after 1:1 propensity score matching (PSM). The mean change in glycated hemoglobin (HbA1c) after 6 months in different groups was evaluated primarily. The secondary outcome was composed of the mean change of fasting plasma glucose (FPG), weight, lipid profile, and homeostasis model assessment. Logistics regression was performed to evaluate the likelihood of reaching different HbA1c levels after 6-month treatment between the groups. Adverse event (AE) was also evaluated in patients of both groups. Results In total, 1088 patients were selected into the analysis. Compared to the control group, subjects in HI group maintained greater improvement in the level of HbA1c (-0.94% vs -0.46%), FPG (-22.7 mg/dL vs -11.7 mg/dL), total cholesterol (-12.9 mg/dL vs -4.4 mg/dL), HOMA-IR (-0.76 vs -0.17) and HOMA-β (8.2% vs 1.98%) with all p< 0.001 post the treatment. Logistics regression revealed that the likelihood of reaching HbA1c< 7%, ≥ 7% to< 8% and > 1% reduction at the follow-up period was higher in the HI group, while patients in the control group were more likely to attain HbA1c ≥ 9%. Patients in HI group was observed a lower incidence of several AEs including hypoglycemia (2.0% vs 6.8%), vomiting (2.6% vs 7.4%), constipation (1.7% vs 4.4%) and giddiness (3.3% vs 6.3%) with significance in comparison to the control group. Conclusion HI as an adjunct therapy ameliorates glycemic control, lipid metabolism, insulin resistance and AE incidence of T2DM patients after 6-month treatment, presenting a noteworthy inspiration to existing clinical diabetic treatment.
Along-slope bottom currents driven by dissipation of internal tides in the northeastern South China Sea

Recent mooring observations on the continental slope on the east side of the Dongsha Island in the northeastern South China Sea (SCS) showed that an along-slope bottom current can be generated when internal tides obliquely incident to the slope are dissipated near the seafloor. In this study, new mooring data collected on the south side of the Dongsha Island are used to explore the universality of internal wave driven the bottom currents and test the ability of the previous theory in estimating the along-slope current. The data show strong near-bottom energy dissipation due to the critical reflection of diurnal internal tides on the continental slope, with a time-mean depth-integrated dissipation rate of ~4.8×10-3 W/m2. Because of the obliquely incident of diurnal internal tides to the slope, near-bottom dissipation of internal tides generates a southwestward along-slope current, with the maximum velocity exceeding 6 cm/s. By comparing the observations, the previous theory for internal wave induced mean flows developed by Thorpe (1999) shows a good ability to estimate the along-slope bottom current velocity. Based on the theory, as well as modelled energy dissipation on the entire continental slope in the northeastern SCS, a map is obtained to quantitatively describe the along-slope bottom flow caused by internal tide breaking on the slope.
Transcriptome profiling reveals the underlying mechanism of grape post-harvest pathogen Penicillium olsonii against the metabolites of Bacillus velezensis

Introduction Pathogen infection influences the post-harvest shelf life of grape berries. In a preliminary study, metabolites produced by Bacillus velezensis significantly inhibited the growth of the grape postharvest pathogen Penicillium olsonii. Methods To investigate the mechanism of interaction between B. velezensis and P. olsonii, a draft genome was generated for P. olsonii WHG5 using the Illumina NovaSeq platform, and the transcriptomic changes in WHG5 were analyzed in response to the exposure to B. velezensis metabolites (10% v/v). Results The expression levels of genes associated with sporulation, including GCY1, brlA, and abaA, were down-regulated compared with those of the control. In addition, spore deformation and abnormal swelling of the conidiophore were observed. The expression of crucial enzymes, including fructose 2,6-bisphosphate and mannitol-2-dehydrogenase, was down-regulated, indicating that the glycolytic pathway of WHG5 was adversely affected by B. velezensis metabolites. The KEGG pathway enrichment analysis revealed that glutathione metabolism and the antioxidant enzyme system were involved in the response to B. velezensis metabolites. The down-regulation of the pathogenesis-related genes, PG1 and POT1, suggested that B. velezensis metabolites decreased the pathogenicity of P. olsonii. B. velezensis metabolites disrupted the homeostasis of reactive oxygen species in P. olsonii by affecting glucose metabolism, resulting in spore deformation and disruption of growth. In addition, the expression of key pathogenesis-related genes was down-regulated, thereby reducing the pathogenicity of P. olsonii. Disscusion This study provides insights into the responses of P. olsonii to B. velezensis metabolites and identifies potential target genes that may be useful in biocontrol strategies for the suppression of post-harvest spoilage in grapes.
Transcranial direct current stimulation for the treatment of post-stroke depression: A systematic review

Background Post-stroke depression (PSD) is not only a frequent neuropsychiatric manifestation secondary to stroke but is also associated with disability, poor rehabilitation outcomes, sleep disorders, cognitive impairment, and increased mortality. Transcranial direct current stimulation (tDCS), a primary modality of non-invasive brain stimulation (NIBS), has shown promising clinical results in the rehabilitation of patients with PSD recently. The primary aim of this systematic review is to assess the effects of tDCS on PSD. Methods PubMed and Cochrane databases were used for paper identification up to May 2022. Only English language studies and published data were taken into consideration. The methodological quality of selected studies was assessed according to the modified Sackett Scale, based on Physiotherapy Evidence Database (PEDro) scores. Results Six experimental studies were included for the PSD treatment of tDCS and all of them reported that, following the intervention of tDCS, the experimental group shows a statistically significant decrease in the depression level in accordance with different assessment scales. Conclusion This article simply aims at providing a comprehensive overview of the raw data reported in this field to date. Based on the current evidence, tDCS presents promising results for the treatment of PSD. Moreover, tDCS is also effective in PSD patients with aphasia or CPSP. However, an optimal stimulation protocol is needed to formulate. Thus, the development of robustly controlled, randomized, and high-quality clinical trials to further assess the utility of tDCS as a therapeutic tool for the treatment of PSD survivors is encouraged. Systematic review registration https://www.crd. york.ac. uk/prospero/display_record. php? ID=CRD42023322076, identifier: CRD42023322076.
Analysis of residual stresses generated by progressive induction hardening of steel cylinders

The internal stresses generated during quenching can produce warping and even cracking of a steel body and, therefore, the prediction of such stresses is an important task. Phenomenological aspects of quenching involve couplings between different physical processes occurring in the phenomena. The present contribution is concerned with modelling and simulation of quenching, presenting an anisothermal model formulated within the framework of continuum mechanics and the thermodynamics of irreversible processes. A numerical procedure is developed based on an operator split technique associated with an iterative numerical scheme in order to deal with non-linearities in the formulation. With this assumption, the coupled governing equations are solved involving four uncoupled problems: thermal, phase transformation, thermoelastic and elastoplastic behaviours. The proposed general formulation is applied to analyse progressive induction hardening of steel cylinders. Numerical results suggest that the proposed model is capable of capturing the main behaviour observed in experimental data.
Relationship of strength, joint kinesthesia, and plantar tactile sensation to dynamic and static postural stability among patients with anterior cruciate ligament reconstruction

Objective: Postural stability is essential for high-level physical activities after anterior cruciate ligament reconstruction (ACLR). This study was conducted to investigate the relationship of muscle strength, joint kinesthesia, and plantar tactile sensation to dynamic and static postural stability among patients with anterior cruciate ligament reconstruction. Methods: Forty-four patients over 6 months post anterior cruciate ligament reconstruction (age: 27.9 ± 6.8 years, height: 181.7 ± 8.7 cm, weight: 80.6 ± 9.4 kg, postoperative duration: 10.3 ± 3.6 months) participated in this study. Their static and dynamic postural stability, muscle strength, hamstring/quadriceps ratio, joint kinesthesia, and plantar tactile sensation were measured. Partial correlations were used to determine the correlation of the above-mentioned variables with time to stabilization (TTS) and root mean square of the center of pressure (COP-RMS) in anterior-posterior (AP) and mediolateral (ML) directions. Results: Both TTSAP and TTSML were related to muscle strength and joint kinesthesia of knee flexion and extension; COP-RMSAP was correlated with plantar tactile sensations at great toe and arch, while COP-RMSML was correlated with joint kinesthesia of knee flexion, and plantar tactile sensation at great toe and heel. Dynamic stability was sequentially correlated with strength and joint kinesthesia, while static stability was sequentially correlated with plantar tactile sensation and joint kinesthesia. Conclusion: Among patients with anterior cruciate ligament reconstruction, strength is related to dynamic postural stability, joint kinesthesia is related to dynamic and static postural stability, and plantar tactile sensation is related to static postural stability. Strength has a higher level of relationship to dynamic stability than joint kinesthesia, and plantar tactile sensation has a higher level of relationship to static stability than joint kinesthesia.
A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan

Background Aging is associated with increased levels of reactive oxygen species and inflammation that disrupt proteostasis and mitochondrial function and leads to organism-wide frailty later in life. ARA290 (cibinetide), an 11-aa non-hematopoietic peptide sequence within the cardioprotective domain of erythropoietin, mediates tissue protection by reducing inflammation and fibrosis. Age-associated cardiac inflammation is linked to structural and functional changes in the heart, including mitochondrial dysfunction, impaired proteostasis, hypertrophic cardiac remodeling, and contractile dysfunction. Can ARA290 ameliorate these age-associated cardiac changes and the severity of frailty in advanced age? Methods We conducted an integrated longitudinal (n = 48) and cross-sectional (n = 144) 15 months randomized controlled trial in which 18-month-old Fischer 344 x Brown Norway rats were randomly assigned to either receive chronic ARA290 treatment or saline. Serial echocardiography, tail blood pressure and body weight were evaluated repeatedly at 4-month intervals. A frailty index was calculated at the final timepoint (33 months of age). Tissues were harvested at 4-month intervals to define inflammatory markers and left ventricular tissue remodeling. Mitochondrial and myocardial cell health was assessed in isolated left ventricular myocytes. Kaplan–Meier survival curves were established. Mixed ANOVA tests and linear mixed regression analysis were employed to determine the effects of age, treatment, and age-treatment interactions. Results Chronic ARA290 treatment mitigated age-related increases in the cardiac non-myocyte to myocyte ratio, infiltrating leukocytes and monocytes, pro-inflammatory cytokines, total NF-κB, and p-NF-κB. Additionally, ARA290 treatment enhanced cardiomyocyte autophagy flux and reduced cellular accumulation of lipofuscin. The cardiomyocyte mitochondrial permeability transition pore response to oxidant stress was desensitized following chronic ARA290 treatment. Concurrently, ARA290 significantly blunted the age-associated elevation in blood pressure and preserved the LV ejection fraction. Finally, ARA290 preserved body weight and significantly reduced other markers of organism-wide frailty at the end of life. Conclusion Administration of ARA290 reduces cell and tissue inflammation, mitigates structural and functional changes within the cardiovascular system leading to amelioration of frailty and preserved healthspan.
Case Report: Septic arthritis in children caused by Streptococcus pyogenes–rational use of antibiotics

To investigate the clinical characteristics and treatment of septic arthritis caused by Streptococcus pyogenes(S. pyogenes) in children, we retrospectively analyzed the clinical data, laboratory results, treatments and outcomes of three pediatric cases of septic arthritis caused by S. pyogenes occurring from 2016–2018. The three cases of septic arthritis included 1 boy and 2 girls, aged from 2–7 years. Two patients experienced fever, and in all three cases, the affected joints showed redness, swelling, an increased local skin temperature, tenderness and restricted limb movement. At the first visit, all three cases showed a significantly increased white blood cell count [(27.68–32.02)×109/mL] and a significantly increased erythrocyte sedimentation rate (113–134 mm/h). The C-reactive protein level was significantly increased in two cases (67 mg/L, 147.7 mg/L) and normal in one case. The procalcitonin level was normal in 1 case, elevated in 1 case, and undetected in 1 case. S. pyogenes isolated from cases 1 and 2 were emm1/ST28 and from case 3 was emm12/ST36. All patients were treated by abscess incision and drainage, and S. pyogenes was cultured in the abscess puncture fluid. All patients were treated with intravenous antibiotics after admission, and all patients were cured and discharged. The patients were followed up for 2 months, and their condition was improved and stable. No sequelae such as heart and kidney damage were detected. In conclusion, for children with septic arthritis, early diagnosis and timely treatment with incision and drainage followed by culture of the abscess puncture fluid are important. Once S. pyogenes infection is confirmed, β-lactam antibiotics provide effective treatment, avoiding use of broad-spectrum antibiotics.
Suffering and happiness in Turkish folk poetry in the context of positive psychology: The examples of Asik Mahzuni Serif and Neset Ertas

The widespread adoption of positive psychology at the beginning of the century has fortified the scholarly foundations of “happiness. ” Thus, researchers have focused on “happiness” rather than “suffering” in boosting the joy of life within positive psychology, aiming for individuals to achieve peace with themselves and society. With the developments in positive psychology, over recent years, the idea of integrating both positive and negative aspects of human nature to build a better life for oneself and others has contributed to the rise of second-wave positive psychology (PP 2.0). The present study aimed to explore suffering and happiness in Turkish folk culture through a sample of poems by Asik Mahzuni Serif and Neset Ertas. The study results indicated that suffering-themed concepts were mentioned more than happiness-themed concepts. Within the theme of suffering, the world was the most frequently mentioned concept in Mahzuni’s works. He emphasizes in his works that the world is the source of many sufferings. In Ertas’s poems, moreover, love was found to be the most frequently mentioned suffering-themed concept. Ertas considers love to be the most significant source of suffering. It was also determined that while separation is the least used concept in the theme of suffering in Mahzuni’s verses, it is never mentioned in Ertas’s poems. Other concepts pointing to the theme of suffering are poverty, ignorance, longing, death, and slavery. We found that the theme of happiness is mentioned much less frequently than the theme of suffering. While the most used happiness-themed concept is misery/remedy, in Mahzuni’s words, love is cited in Ertas’s poems. Expressing the view that suffering can be an opportunity for people, Mahzuni emphasizes in his poems that people can grow by learning lessons from their suffering. Ertas, moreover, sees love as the most important source of happiness. The other concepts referencing happiness in the poems were friend, mother, soft answer, and spring. Overall, the results suggest that suffering is an important source of building resilience, which, in turn, can produce happiness. People can grow with the help of the experience of suffering so that this experience can contribute to their flourishing.
Exogenous γ-aminobutyric acid (GABA) mitigated salinity-induced impairments in mungbean plants by regulating their nitrogen metabolism and antioxidant potential

Background Increasing soil salinization has a detrimental effect on agricultural productivity.Therefore, strategies are needed to induce salinity-tolerance in crop species for sustainable foodproduction. γ-aminobutyric acid (GABA) plays a key role in regulating plant salinity stresstolerance. However, it remains largely unknown how mungbean plants (Vigna radiata L.) respondto exogenous GABA under salinity stress. Methods Thus, we evaluated the effect of exogenous GABA (1.5 mM) on the growth and physiobiochemicalresponse mechanism of mungbean plants to saline stress (0-, 50-, and 100 mM [NaCland Na2SO4, at a 1:1 molar ratio]). Results Increased saline stress adversely affected mungbean plants' growth and metabolism. Forinstance, leaf-stem-root biomass (34- and 56%, 31- and 53%, and 27- and 56% under 50- and 100mM, respectively]) and chlorophyll concentrations declined. The carotenoid level increased (10%)at 50 mM and remained unaffected at 100 mM. Hydrogen peroxide (H2O2), malondialdehyde(MDA), osmolytes (soluble sugars, soluble proteins, proline), total phenolic content, andenzymatic activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), peroxidase(POD), glutathione reductase (GTR), and polyphenol oxidation (PPO) were significantlyincreased. In leaves, salinity caused a significant increase in Na+ concentration but a decrease inK+ concentration, resulting in a low K+/Na+ concentration (51- and 71% under 50- and 100- mMstress). Additionally, nitrogen concentration and the activities of nitrate reductase (NR) andglutamine synthetase (GS) decreased significantly. The reduction in glutamate synthase (GOGAT)activity was only significant (65%) at 100 mM stress. Exogenous GABA decreased Na+, H2O2,and MDA concentrations but enhanced photosynthetic pigments, K+ and K+/Na+ ratio, Nmetabolism, osmolytes, and enzymatic antioxidant activities, thus reducing salinity-associatedstress damages, resulting in improved growth and biomass. Conclusion Exogenous GABA may have improved the salinity tolerance of mungbean plants by maintaining their morpho-physiological responses and reducing the accumulation of harmfulsubstances under salinity. Future molecular studies can contribute to a better understanding of themolecular mechanisms by which GABA regulates mungbean salinity tolerance.
Case report: A de novo Non-sense SOX9 mutation (p.Q417*) located in transactivation domain is Responsible for Campomelic Dysplasia

Background Campomelic dysplasia (CD) is an autosomal dominant skeletal dysplasia syndrome characterized by shortness and bowing of lower extremities, and often accompanied by XY sex reversal. Heterozygous pathogenic variants of SOX9 or rearrangement involving the long arm of chromosome 17 are the causes of disease. However, evidence for pathogenesis of SOX9 haploinsufficiency is insufficient. Methods We enrolled a Chinese family where the fetus was diagnosed with CD. The affected fetus was selected for whole-exome sequencing to identify the pathogenic mutations in this family. Results After data filtering, a novel non-sense SOX9 variant (NM_000346.3; c.1249C > T; p.Q417*) was identified as the pathogenic lesion in the fetus. Further co-segregation analysis using Sanger sequencing confirmed that this novel SOX9 mutation (c.1249C > T; p.Q417*) was a de novo mutation in the affected fetus. This terminated codon mutation identified by bioinformatics was located at an evolutionarily conserved site of SOX9. The bioinformatics-based analysis predicted this variant was pathogenic and affected SOX9 transactivation activity. Conclusion CD is a rare condition, which connected with SOX9 tightly. We identified a novel heterozygous SOX9 variant (p.Q417*) in a Chinese CD family. Our study supports the putative reduced transactivation of SOX9 variants in the pathogenicity of CD.
Distinct leaf functional traits of Tamarix chinensis at different habitats in the hinterland of the Taklimakan desert

Leaf functional traits reflect plant adaptive strategies towards environmental heterogeneity. However, which factor play the key role of plasticity of leaf functional traits among various variable environmental factors remains unclear in desert hinterland oasis area. Here, we analyzed variations in leaf water content (LWC), δ 13C values of leaves (δ 13C), specific leaf area (SLA), leaf organic carbon concentration (LOC), leaf total nitrogen concentration (LTN), leaf total phosphorus concentration (LTP), and leaf C: N: P stoichiometry in Tamarix chinensis growing in five habitats at the Daliyabuyi, a natural pristine oasis in northwestern China, that differ abiotically and biotically. The spatial heterogeneity of leaf functional traits was evident. Abiotic factors vitally influence leaf functional traits, of which groundwater depth (GWD) and soil C: N stoichiometry (SOC: STN) are crucial. GWD exhibited close relationships with LWC (P < 0.05) and LOC: LTP (P < 0.01), but not δ 13C. Soil water content (SWC) and SOC: STN were negatively related to SLA (P < 0.01; P < 0.05). While, SOC: STN showed positive relationships with LOC: LTN (P < 0.05). As for biological factors, we found T. chinensis in habitat with Sophora alopecuroidies had the highest LTN, possibly as a result of N fixation of leguminous plants (S. alopecuroidies) promotes the N concentration of T. chinensis. Close relationships also existed between leaf functional traits, LWC showed significantly negatively relatd to δ 13C, LOC: LTN and LOC: LTP (P < 0.05), whereas δ 13C had positively correlated with LOC: LTN (P < 0.01) but negatively correlated with LTN (P < 0.05). T. chinensis had relative higher LWC couple with lower δ 13C, and exhibiting lower C, N, P in leaves and their stoichiometric ratios, and also lower SLA which compared with other terrestrial plant. Such coordinations suggesting that T. chinensis develops a suite of trait combinations mainly tends to more conservative to response local habitats in Daliyabuyi, which is contribute to understand desert plant resource acquisition and utilization mechanisms in extremely arid and barren environments.