Miracle-dz/UniFAR-FTUs huggingface dataset:
Breeding Population Dynamics of Threatened Crawfish Frogs Inform Targets for Habitat Management

We used data from a five-year study at two focal breeding wetlands of a single Crawfish Frog (Rana areolata) population to demonstrate the relative importance and potential of tadpole survival as a target for population management. We concurrently estimated 11 vital rates in the field and used a females-only matrix projection model to estimate elasticities of demographic rates. We then simulated stochastic population dynamics at each wetland with and without immigration to estimate the intrinsic capacity for each focal breeding wetland to sustain a Crawfish Frog breeding population and the likelihood of breeding population persistence at each wetland. Elasticity of tadpole survival was second only to juvenile survival elasticity and 1.34–2.04 times greater than adult survival elasticity. Projections indicated that the Crawfish Frog population was not at risk of extinction but only one breeding site was capable of self-sustaining a breeding population. Because of low tadpole survival, the other breeding site was completely dependent on immigration to persist and was functioning as a population sink. Despite higher variability compared to terrestrial vital rates, larval survival did have a strong effect on population growth. Tadpole survival at the more productive breeding site was density dependent and likely related to wetland vegetation and predator and competitor abundance. Two additional findings were that annual survival of frogs following their first known breeding event was 48% lower compared to survival of frogs that had bred in two or more prior years, and adult temporary emigration from the breeding population was moderately high. Our study demonstrates the benefits of using population models that integrate density-dependent processes, temporary emigration from the breeding population, and state-specific adult survival, to identify larval habitats that function as population sinks and limit current population size and persistence probability. We contend that tadpole survival is an important and feasible habitat management target within broader conservation strategies for Crawfish Frogs and other amphibian species.
Laser beam propagation in jet engine plume environments: a review

Laser beam propagation through adverse turbulent environments such as the region close to a jet engine exhaust need to be studied in order to predict performance degradations on airborne laser systems. The turbulent plume region may introduce severe perturbations which accumulate and cause beam degradation in terms of beam wander, intensity scintillations and beam broadening at longer ranges. Applications of interest with respect to laser beam propagation in jet engine plume environments include e.g. directed infrared countermeasures (DIRCM) and active imaging. By characterising and evaluating the perturbation effects schemes for compensation or avoiding performance degradation can be devised. The turbulence effects in the plume region occur by mixing of hot exhaust flow from the jet engine with surrounding ambient air causing spatial and temporal fluctuations in the refractive index. In comparison to atmospheric turbulence considerably shorter outer- and inner scales have been observed. Typical values of the structure constant within the plume region range from 10-10 to 10-9 m-2/3 making the turbulence several order in magnitude stronger in contrast to propagation through the atmosphere. Of importance in characterisation of the jet engine plume with respect to laser beam propagation are turbulent length scales, the extent of the turbid region, variation of the structure constant and temporal flow properties. In this paper reported experimental results and modelling approaches aimed for predicting laser beam propagation degradation in jet engine plume regions are reviewed. The results will be discussed in perspective of system performance.
Formation of thin flat sheets of water

A thin plane sheet of fluid which is limited laterally and converges towards a point transforms itself into a sheet which diverges in a perpendicular plane. When the angle of convergence is small and the distribution of thickness in the converging sheet is elliptic the diverging sheet has the same shape as the converging sheet. Apparatus for producing such a sheet was set up and the shape of the stream and distribution of pressure in the region of the transformation were measured and compared with calculations.
Model Selection Via Multifold Cross Validation

In model selection, it is known that the simple leave one out cross validation method is apt to select overfitted models. In an attempt to remedy this problem, we consider two notions of multi-fold cross validation (MCV and MCV*) criteria. In the case of linear regression models, their performance is studied and compared with the simple CV method. As expected, it turns out that MCV indeed reduces the chance of overfitting. The intent ofMCV' is rather different from that of MCV. The differences between these two notions of MCV are also discussed. Our result explains the phenomena observed by Breiman & Spector.
Plasmonic lithography modeling and measurement of near-field distribution of plasmonic nano-aperture

In plasmonic nano lithography, a photoresist responds to the localized electric field which decays evanescently in the direction of depth. A simple analytic model is suggested to predict profiles of exposed and finally developed pattern with a finite contrast of photoresist. In this model, the developing process is revisited by accounting the variation of dissolution rate with respect to expose dose distribution. We introduce the concept of nominal developing thickness (NDT) to determine the optimized developing process fitting to the isointensity profile. Based on this model, we obtained three dimensional distribution of near-field of bowtie shaped plasmonic nano aperture in a metal film from the near-field lithography pattern profile. For the near-field exposure, we fabricated a nano aperture in a aluminum metal film which is coated on the contact probe tip. By illuminating 405 nm diode laser source, the positive type photoresist is exposed by the localized electric field produced by nano aperture. The exposed photoresist is developed by the TMAH based solution with a optimum NDT, which leads the developing march encounters the isoexposure contour at threshold dose. From the measurement of developed pattern profile with a atomic force microscope (AFM), the three-dimensional isoexposure (or iso-intensity) surface at the very near region from the exit plane of an aperture (depth: 5 ~ 50 nm) is profiled. Using the threshold dose of photoresist and exposure time, the absolute intensity level is also measured. The experimental results are quantitatively compared with the calculation of FDTD (finite- difference time-domain) method. Concerning with the error in exposure time and threshold dose value, the error in measurement of profile and intensity are less than 6% and 1%, respectively. We expect the lithography model described in this presentation allows more elaborated expectation of developed pattern profile. Furthermore, a methodology of mapping is useful for the quantitative analysis of near-field distribution of nano-scale optical devices.
Transient Response to Localized Episodic Heating in the Tropics. Part II: Far-Field Behavior.

Abstract In Part I of this investigation, we described the stochastic, near-field behavior of disturbances excited by randomly evolving tropical heating. In the present paper, we examine how these disturbances are modified as they propagate through the far field in the presence of spatially-varying background states. Although the behavior can no longer be broken down into individual Hough modes, it can still be understood in terms of projection and barotropic components of the response. Responses to fast heating, as may be produced by daily fluctuations in convection, and to slow heating, evolving over seasonal time scales, are studied separately. For fast heating the projection response consists mainly of a spectrum of Kelvin waves which, in the lower stratosphere, is centered at frequencies corresponding to twice the effective depth of the heating. The spectrum shifts to higher frequency with increasing altitude due to differential damping. As a result, the slow, fast and ultrafast Kelvin waves identifi.
Exposure-based treatments for childhood abuse-related post-traumatic stress disorder in adults: a health-economic evaluation

ABSTRACT Background: Prolonged exposure (PE) is an effective treatment for post-traumatic stress disorder (PTSD). Objective: This study aimed to analyse the cost-effectiveness of three exposure-based treatments in patients with childhood abuse-related PTSD. Method: A net–benefit analysis was conducted alongside a pragmatic randomized controlled trial with participants (N = 149) randomized to three conditions: PE (n = 48), intensified PE (i-PE, n = 51), and phase-based PE [Skills Training in Affective and Interpersonal Regulation (STAIR) + PE, n = 50]. Assessments took place at baseline (T0), post-treatment (T3), 6 month follow-up (T4), and 12 month follow-up (T5). Costs stemming from healthcare utilization and productivity losses were estimated using the Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness. Quality-adjusted life-years (QALYs) were based on the 5-level EuroQoL 5 Dimensions (EQ-5D-5L) using the Dutch tariff. Missing values of costs and utilities were multiply imputed. To compare i-PE to PE and STAIR + PE to PE, pair-wise unequal-variance t-tests were conducted. Net–benefit analysis was used to relate costs to QALYs and to draw acceptability curves. Results: Intervention costs did not differ across the three treatment conditions. Total medical costs, productivity losses, total societal costs, and EQ-5D-5L-based QALYs did not differ between treatment conditions either (all p > .10). At the relevant €50,000/QALY threshold, the probability of one treatment being more cost-effective than another was 32%, 28%, and 40% for PE, i-PE, and STAIR-PE, respectively. Conclusion: Three equally effective treatments were compared and no differences in cost-effectiveness between treatments were found. Therefore, we advocate the implementation and adoption of any of the treatments and endorse shared decision making. HIGHLIGHTS This is the first study to compare cost-effectiveness of three exposure-based treatments in patients with CA-PTSD alongside a randomized controlled clinical trial (N = 149). The three exposure-based treatments did not differ in terms of outcomes and costs. Findings underline that any of these treatments can be implemented, and we endorse shared decision making to meet patient treatment preference.
Curcumin-Mediated Resistance to Lenvatinib via EGFR Signaling Pathway in Hepatocellular Carcinoma

Lenvatinib is a multi-kinase inhibitor approved as a first-line treatment for patients with unresectable advanced hepatocellular carcinoma (HCC). However, its response rate is unsatisfactory, primarily due to the acquisition of resistance, which limits its clinical significance for treating patients with HCC. Recent evidence suggests that epidermal growth factor receptor (EGFR) activation can trigger Lenvatinib-resistance; and is considered an important therapeutic target in HCC. Curcumin, one of the most studied naturally occurring botanicals with robust anti-cancer activity, is also reported to be a potent tyrosine kinase inhibitor. In this study, we hypothesized that the anti-EGFR potential of Curcumin might help overcome Lenvatinib resistance in HCC. We established two Lenvatinib-resistant cells and discovered that a combination of Curcumin and Lenvatinib exhibited a synergistic anti-tumor efficacy in the resistant HCC cell lines. In line with previous reports, Lenvatinib-resistant cell lines revealed significant activation of the EGFR, and genomewide transcriptomic profiling analysis identified that the PI3K-AKT pathway was associated with Lenvatinib resistance. The combination treatment with Curcumin and Lenvatinib dramatically suppressed gene and protein expression of the EGFR-PI3K-AKT pathway, suggesting Curcumin overcomes Lenvatinib resistance via inhibition of EGFR. We further validated these findings in tumor spheroids derived from resistant cell lines. In conclusion, we, for the first time, report that Curcumin reverses Lenvatinib resistance in HCC, and that their combination has clinical application potential for adjunctive treatment in HCC.
Correlation between salivary immunoglobulin A and interleukin-1beta in smokers with dental caries

Introduction. Dental caries is one of the most common infectious diseases of the oral cavity, and is an inflammatory disease caused by several factors. Interleukin-1β (IL-1β) is a major mediator of acute inflammation and essential for the development of specific immune responses. The objective of this study was to assess the levels of secretory IgA (s-IgA) and IL-1β in the saliva of smokers with dental caries, and to discover the correlation between these parameters and dental caries. Methods. Saliva samples were collected from 30 smokers, age range 21–70 years, with dental caries, in addition to 18 healthy non-smoker volunteers, age range 21–65 years. s-IgA and IL-1β levels in the saliva samples were estimated by enzyme-linked immunosorbent assay (ELISA). Results. The mean saliva IgA levels between smokers with dental caries group and healthy subjects were not significantly different (p=0.077), while the saliva levels of IL-1β were higher in the smokers in dental caries group, with a significant difference of p<0.05. No significant associations were found between s-IgA and IL-1β levels, and other parameters such as age, sex, body mass index (BMI) and C-reactive protein (CRP) (p>0.05). There were highly positive associations and significant differences between IL-1β and CRP levels in the two groups under the study (p=0.006). Conclusions. Our study revealed a significant increase in IL-1β levels in saliva of smokers with dental caries, and a positive association between IL-1β levels and caries disease. There is no significant relationship between elevated IL-1β levels and s-IgA in smokers with dental caries.
Effects of Exponential N Application on Soil Exchangeable Base Cations and the Growth and Nutrient Contents of Clonal Chinese Fir Seedlings

Nitrogen (N) is an essential macronutrient for plant function and growth and a key component of amino acids, which form the building blocks of plant proteins and enzymes. However, misuse and overuse of N can have many negative impacts on the ecosystem, such as reducing soil exchangeable base cations (BCs) and causing soil acidification. In this research, we evaluated clonal Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) seedlings grown with exponentially increasing N fertilization (0, 0.5, 1, 2 g N seedling−1) for a 100-day trial in a greenhouse. The growth of seedlings, their nutrient contents, and soil exchangeable cations were measured. We found that N addition significantly increased plant growth and N content but decreased phosphorous (P) and potassium (K) contents in plant seedlings. The high nitrogen (2 g N seedling−1) treated seedlings showed a negative effect on growth, indicating that excessive nitrogen application caused damage to the seedlings. Soil pH, soil exchangeable base cations (BCs), soil total exchangeable bases (TEB), soil cation exchange capacity (CEC), and soil base saturation (BS) significantly decreased following N application. Our results implied that exponential fertilization resulted in soil acidification and degradation of soil capacity for supplying nutrient cations to the soil solution for plant uptake. In addition, the analysis of plants and BCs revealed that Na+ is an important base cation for BCs and for plant growth in nitrogen-induced acidified soils. Our results provide scientific insights for nitrogen application in seedling cultivation in soils and for further studies on the relationship between BCs and plant growth to result in high-quality seedlings while minimizing fertilizer input and mitigating potential soil pollution.
3D magnetohydrodynamic modelling of a dc low-current plasma arc batch reactor at very high pressure in helium

This paper deals with a three-dimensional (3D) time-dependent magnetohydrodynamic (MHD) model under peculiar conditions of very high pressures (from 2 MPa up to 10 MPa) and low currents (<1 A). Studies on plasma arc working under these unusual conditions remain almost unexplored because of the technical and technological challenges to develop a reactor able to sustain a plasma at very high pressures. The combined effect of plasma reactivity and high pressure would probably open the way towards new promising applications in various fields: chemistry, lightning, materials or nanomaterial synthesis. A MHD model helps one to understand the complex and coupled phenomena surrounding the plasma which cannot be understood by simply experimentation. The model also provides data which are difficult to directly determine experimentally. The model simulates an experimental-based batch reactor working with helium. The particular reactor in question was used to investigate the Fischer–Tropsch application, fluorocarbon production and CO2 retro-conversion. However, as a first approach in terms of MHD, the model considers the case for helium as a non-reactive working gas. After a detailed presentation of the model, a reference case has been fully analysed (P = 8 MPa, I = 0.35 A) in terms of physical properties. The results show a bending of the arc and displacement of the anodic arc root towards the top of the reactor, due to the combined effects of convection, gravity and electromagnetic forces. A parametric study on the pressure (2–10 MPa) and current (0.25–0.4 A) was then investigated. The operating pressure does not show an influence on the contraction of the arc but higher pressures involve a higher natural convection in the reactor, driven by the density gradients between the cold and hot gas.
An integrated equivalent circuit model for relative intensity noise and frequency noise spectrum of a multimode semiconductor laser

Relative intensity noise (RIN) and the frequency/phase noise spectrum (FNS) equivalent circuit of a multimode semiconductor laser diode are derived from multimode rate equations with the inclusion of noise Langevin sources. FNS is an important parameter in optical communication systems, and its circuit model is presented, for the first time, in this paper. Both circuit models for RIN and FNS are integrated in one circuit. RIN and FNS are calculated as functions of frequency, output power, and mode number. It is shown that the RIN of the main mode is increased in the multimode lasers with higher mode numbers. Furthermore, we show that RIN and FNS are enhanced for higher output power. The dependency of a multimode laser diode linewidth on output power is also analyzed using the model.
Revisiting the role of magnetic moments in heliospheric plasmas

The magnetic moment is one of the most fundamental, nontrivial particle properties known in plasma physics. Also known as the first adiabatic invariant, it is conserved under a broad range of microphysical processes and plasma boundary conditions. However, especially in modern numerical simulations, the conservation of this property, which in principle may serve as a control parameter, is no longer used explicitly. In light of this fact, as well as in a recent series of studies of the solar wind termination shock and comparable systems, where this conservation was used as a key ingredient, we now revisit this old, but standing problem. Building on our earlier arguments on when the magnetic moment of individual particles is conserved, we now carefully expand this argument further, studying nontrivial systems, such as systems where individual ions are represented by a broad distribution function that is described with the help of a transport equation. We see that the magnetic moment is conserved under an even wider variety of situations than those studied in earlier publications. When studying systems of purely kinetic equations, the magnetic moment can be converted into an additional force term in the transport equation. We also study the physics that is taken into account in shock simulations and pinpoint weaknesses in the physics used by these modern codes.
Engineered mesenchymal stem cell-derived extracellular vesicles: A state-of-the-art multifunctional weapon against Alzheimer's disease

With the increase of population aging, the number of Alzheimer's disease (AD) patients is also increasing. According to current estimates, approximately 11% of people over 65 suffer from AD, and that percentage rises to 42% among people over 85. However, no effective treatment capable of decelerating or stopping AD progression is available. Furthermore, AD-targeted drugs composed of synthetic molecules pose concerns regarding biodegradation, clearance, immune response, and neurotoxicity. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are essential intercellular communication mediators holding great promise as AD therapeutics owing to their biocompatibility, versatility, effortless storage, superior safety, and the ability to transport messenger and noncoding RNAs, proteins, lipids, DNAs, and other bioactive compounds derived from cells. The functionalisation and engineering strategies of MSC-EVs are highlighted (e.g. preconditioning, drug loading, surface modification, and artificial EV fabrication), which could improve AD treatment by multiple therapeutic effects, including clearing abnormal protein accumulation and achieving neuroprotection and immunomodulatory effects. Herein, this review summarises state-of-the-art strategies to engineer MSC-EVs, discusses progress in their use as AD therapeutics, presents the perspectives and challenges associated with the related clinical applications, and concludes that engineered MSC-EVs show immense potential in AD therapy.
Three-dimensional spectrum of temperature fluctuations in stably stratified atmosphere

A phenomenological model is proposed for a 3-D spectrum of temperature inhomogeneities generated by inter- nal waves in the atmosphere. This model is a development of the theory based on the assumption that a field of Lagrangian displacements of fluid particles, induced by an ensemble of internal waves with randomly independent amplitudes and phases, is statistically stationary, homogeneous, axially sym- metric in horizontal plane and Gaussian. For consistency of this model with measured spectra of temperature fluctuations in the stratosphere and mesosphere the additional assump- tion was introduced in to the model about the anisotropy of inhomogeneities to be dependent on their vertical sizes. The analytic expressions for both the 3-D and 1-D spectra are obtained. A model vertical wave number spectrum fol- lows a 3 power law, whereas a horizontal spectrum con- tains two regions with a 3 slope, and the intermediate re- gion with the slope between 1 and 3 depending on the rate of anisotropy decrease as a function of increasing sizes of the inhomogeneities. In the range of a few decades the model showed a good agreement with the results of mea- surements of the spectra in the troposphere, stratosphere and mesosphere.