Miracle-dz/UniFAR-FTUs huggingface dataset:
Pilot Study for the Dietary Assessment of Xenobiotics Derived from Food Processing in an Adult Spanish Sample

Background: Although xenobiotics from food processing have gained support as possible drivers of the relationship between diet and some types of cancer, there are still few studies characterizing the intake of these compounds among different populations. Aim: To describe the intake of heterocyclic amines (HAs), polycyclic aromatic hydrocarbons (PAHs), nitrates, nitrites, nitrosamines, and acrylamide; and to identify dietary and lifestyle related factors. Methods: This was a descriptive cross-sectional study in 70 adult volunteers. Intake was registered by means of a food frequency questionnaire, including cooking methods, temperature, and degree of browning. The European Prospective Investigation into Cancer (EPIC) and the Computerized Heterocyclic Amines Resource for Research in Epidemiology of Disease (CHARRED) databases were used for xenobiotic estimation in conjunction with data from the European Food Safety Authority (EFSA) and U.S. Food and Drug Administration (FDA). Results: Dietary HAs (amino-alpha-carboline (AαC), 2-amino-3-methylimidazo (4,5,f) quinoline (IQ), 2-amino-3,8 dimethylimidazo (4,5,f) quinoxaline (MeIQx), 2-amino-3,4,8 trime-thylimidazo (4,5,f) quinoxaline (DiMeIQx), and 2-amino-1-methyl-6-phenylimidazo (4,5,b) pyridine (PhIP)) were mainly derived from meat and meat products, while benzo (a) pyrene (B(a)P), dibenzo (a) anthracene (DiB(a)A), and total PAHs were explained by oils and fats, alcoholic beverages, and milk, respectively. Microwaved, fried, grilled, broiled, barbecued, and braised cooking methods were mainly responsible for HAs and PAHs consumption. Conclusion: Based on the wide presence and levels of intake of these compounds in different sources, more efforts should be made to adjust their intake to the levels recommended by health agencies.
Insights on Transmission, Spread, and Possible Endemization of Selected Arboviruses in Israel—Interim Results from Five-Year Surveillance

Outbreaks of arthropod-borne (arbo) viruses that infect livestock impact the health and welfare of domestic and wild animals are often responsible for significant economic losses in livestock production. Surveillance and early warning systems effectively predict the emergence and re-emergence of arboviral disease. This paper presents the interim results of five years monitoring the exposure of sentinel naïve heifers and Culicoides biting midges (Diptera; Ceratopogonidae) to bovine ephemeral fever virus (BEFV), Simbu serogroup viruses, bluetongue viruses (BTV), and epizootic hemorrhagic disease viruses (EHDV). The data were collected from 11 dairy farms situated within eight different geographical regions in Israel. The results indicate that cattle in Israel are affected by all four viruses from the early summer onward. The investigated viruses exhibit unique site-specific profiles in both ruminants and vectors. The potential of several vectors to transmit these viruses and lack of cross-protection to re-infection with multiple serotypes (BTV and EHDV) or species (Simbu serogroup viruses) highlights some likely mechanisms that may play a role in these viruses’ maintenance cycle and possible endemization in our region.
Numerical Simulation of the Response of Concrete Structural Elements Containing a Self-Healing Agent

Self-healing of a crack is a relatively novel technique allowing for the partial recovery of the initial mechanical characteristics of a structural element after some period of exploitation. By a widely accepted convention, self-healing is either autogenous or autonomous. The former is a mechanism inherent for cementitious composites (in particular—concrete), while the latter is an engineered process. Both autogenous and engineered healing have recently been the object of numerous studies. Despite the large amount of research work being carried out, the potential of this technique has not yet been fully realized. The article focuses on the modeling and the finite element simulation of the recovery of the initial material properties resulting from the sealing of cracks. The employed numerical procedure uses a constitutive relation for concrete based on the continuum damage mechanics. It captures both the strain-softening and the inverse process—the crack healing. Finite element simulations of benchmark cases illustrate the effect of self-healing. The numerically obtained constitutive relations for specimens with and without a healing agent are compared.
Allele-specific polymerase chain reaction for the discrimination of elite Korean cattle associated with high beef quality and quantity

Abstract Techniques such as direct sequencing and PCR-RFLP (restriction fragment length polymorphism) are widely used to analyze the genotypes of livestock. However, these conventional methods have the disadvantage of taking a lot of time and incurring considerable cost. The allele-specific PCR method performs PCR using two primers, and a single nucleotide polymorphism (SNP) genotype can be identified through electrophoresis, saving time and cost. Highly accurate results can be obtained by designing specific primers according to the allele of the SNP under study, utilizing primer binding to a complementary matching sequence. In this study, we established a genotyping system with the AS-PCR technique, using SNPs related to the improvement of the meat quality and meat mass of Korean cattle. Using the PRIMER1 program, we designed specific primers for SNPs located at the 3 ′ end, with one SNP marker in the HSPB1 gene related to meat quantity and two SNP markers in the ADH1C and FASN genes related to meat quality in cattle. AS-PCR was performed on 10 Korean cattle using the primers designed with this system, and the genotypes could be identified by the size of the PCR product amplified as a result of electrophoresis. In the case of the HSPB1 g.2352T > C SNP, the T allele was amplified to 148 bp, and the C allele was amplified to 222 bp. The ADH1C c. -64T > C SNP was amplified to 492 bp at the T allele and 330 bp at the C allele. The FASN g.17924G > A SNP A allele was amplified to 377 bp and the G allele to 507 bp. The results for each SNP genotype were verified using direct sequencing, which showed that the genotypes identified by direct sequencing and the genotypes identified by the AS-PCR method matched exactly. The AS-PCR method therefore appears to be valuable for use in a genotyping system.
Sinkhole Flooding and Aquifer Recharge in Arid to Dry Sub-Humid Regions: A Systematic Review in the Perspective of Climate Change

On the one hand, Sinkhole Flooding (SF) is an essential hydrological process to recharge karst aquifer in arid to dry sub-humid regions. On the other hand, the increase of rain extremes is one of the major consequences of global warming, together with the expansion of drylands. Thus, appropriate runoff regulation in endorheic karst basins in order to reduce the risk of flooding and improve the quantity and quality of the water drained by sinkholes will be more and more crucial. With these premises, a systematic review of SF cases study was performed by using Web of Science (WoS) engine to infer the hydrological properties for modeling the water management in regions actually or potentially affected by water scarcity. Hydrological models are essential to manage the consequences of climate change on karst water resource, however the review shows that providing the tools necessary for reliable modeling is still challenging. Finally, due to the intrinsic vulnerability of the karst aquifers, pollution reduction and wastewater recycling policy will play a key role in the next decades.
Efficacy, Safety and Patient-Reported Outcomes with Preservative-Free (PF) Tafluprost or PF-Dorzolamide/Timolol Compared with Preserved Latanoprost: A Prospective Multicenter Study in Korean Glaucoma Patients with Ocular Surface Disease

To compare the efficacy, patient-reported satisfaction, and safety of preservative-free (PF)-tafluprost, PF-dorzolamide/timolol and preservative-containing (P)-latanoprost in Korean glaucoma patients with ocular surface disease (OSD). In a multicenter, prospective, interventional, non-randomized, controlled 12-week trial, 107 eligible patients received PF-tafluprost (n = 37), PF-dorzolamide/timolol (n = 34), or P-latanoprost eye drops (n = 36). Outcomes included changes from baseline in OSD Index (OSDI) scores (primary endpoint), intraocular pressure (IOP), and patient-reported treatment satisfaction, and safety at 12 weeks. At 12 weeks, the mean total OSDI and subdomain (dry eye symptoms, visual-related function, environmental triggers) scores significantly improved from baseline with PF-tafluprost and PF-dorzolamide/timolol, but not with P-latanoprost. Significantly more PF-tafluprost than P-latanoprost recipients reported ‘highly improved/improved’ satisfaction (no significant difference between PF-dorzolamide/timolol and P-latanoprost). IOP changes were comparable among all three treatment groups. No new safety concerns were observed. PF-tafluprost and PF-dorzolamide/timolol showed statistically and clinically significant reductions in OSDI compared with P-latanoprost in Korean glaucoma patients with OSD.
Validation of a Food Knowledge Questionnaire on Tanzanian Women of Childbearing Age

The present manuscript describes the validation of a food knowledge questionnaire (FKQ) for Tanzanian childbearing age women. The FKQ was derived from the Ugandan version and was adapted according to Tanzanian culture and food habits, including 114 closed-ended questions, divided into five different sections. The FKQ was administered to 671 Tanzanian childbearing-age women who were eligible if they: (i) were aged between 14 and 49 years old, (ii) had not been diagnosed with any disease and (iii) lived in the urban or peri-urban area of the Arusha and Morogoro region. The validation process of the FKQ was conducted in Tanzania and the recruitment occurred between August and October 2020. The final version of the validated questionnaire was characterized by a total of 88 questions, divided into ten different sections; each section aimed to investigate a different aspect of food knowledge, except for section A, which collected information related to the social and demographic characteristics of the respondent. The food knowledge questionnaire showed good construct validity and content validity to assess knowledge and food practices in Tanzanian women of childbearing age and could be used in future studies to identify women at higher risk of unhealthy eating habits and food choices.
Solution Approach for Bus Transit Model with a Rectangular Service Area

This paper studies the solution procedure of a bus transit system with a rectangular service area that had been cited more than two hundred times. We will point out that they applied relations suitable for continuous variables, which are not held for a discrete variable and will result in invalid results. We provide our solution procedure to the same example proposed by the original paper to illustrate that their results are less accurate. Our findings will help researchers understand this kind of bus transit system.
Protein Lipidation by Palmitate Controls Macrophage Function

Macrophages are present in all tissues within our body, where they promote tissue homeostasis by responding to microenvironmental triggers, not only through clearance of pathogens and apoptotic cells but also via trophic, regulatory, and repair functions. To accomplish these divergent functions, tremendous dynamic fine-tuning of their physiology is needed. Emerging evidence indicates that S-palmitoylation, a reversible post-translational modification that involves the linkage of the saturated fatty acid palmitate to protein cysteine residues, directs many aspects of macrophage physiology in health and disease. By controlling protein activity, stability, trafficking, and protein–protein interactions, studies identified a key role of S-palmitoylation in endocytosis, inflammatory signaling, chemotaxis, and lysosomal function. Here, we provide an in-depth overview of the impact of S-palmitoylation on these cellular processes in macrophages in health and disease. Findings discussed in this review highlight the therapeutic potential of modulators of S-palmitoylation in immunopathologies, ranging from infectious and chronic inflammatory disorders to metabolic conditions.
The Loss of Smell and Taste in the COVID-19 Outbreak, A Cross Sectional Study

Background: A significant proportion of people infected with COVID-19 report new onset of smell and taste loss. The duration of the chemosensory impairment and prognostic factors of recovery is still unclear. We aimed to investigate the prevalence rate and other signs and symptoms which are predictors in patients. Objective: To find out the association of Anosmia and Ageusia with COVID-19. To find out relationship of Gender with Anosmia and Ageusia in COVID-19 or other URTI. Methods: I was a cross-sectional study, participants were from CMH, Multan, Hospitals of different cities of the province of Punjab, Pakistan. The study was conducted from 1st July to 31st of August 2021. 185. All faculty members and medical Students of CMH Bahawalpur. Results: Out of 185 participants, 99 (53.5%) were male and 86 (46.5%) were female. The mean age was 23.93 ± 6.661years. Pearson correlation of covid-19 with loss of smell is 0.533 which shows that there is strong positive relationship between them. On one-way ANOVA fever sig. is 0.002 which shows high significance. URTI also shows association but other signs and symptoms like dyspnoea, dry cough do not show any significance. Shows the majority of participants are suffering from taste and smell loss (95.1%) along with body aches (82.7%), dyspnoea (94.6%), acute dry cough (36.2%), URTI (19.5%) and fever (36.2%).
Systematic Review of the Effects of Exercise and Physical Activity on the Gut Microbiome of Older Adults

Recent evidence suggests that exercise/physical activity (PA) can beneficially alter the gut microbiome composition of young people, but little is known about its effects in older adults. The aim of this systematic review was to summarize results of human studies that have assessed the effects/associations of PA/exercise on the gut microbiome of older adults and to better understand whether this can help promote healthy ageing. Seven studies were included in the review and overall, exercise and increased amounts of PA were associated with decreases in the abundance of several well-known harmful taxa and increases in the abundance of health-promoting taxa. Altogether, the findings from the included studies suggest that exercise/PA have a beneficial impact on the gut health of older adults by improving the gut microbiome composition. However, due to methodological and sampling disparities, it was not possible to reach a consensus on which taxa were most affected by exercise or PA.
Holocene Tephrostratigraphy in the East Sea/Japan Sea: Implications for Eruptive History of Ulleungdo Volcano and Potential for Hemispheric Synchronization of Sedimentary Archives

Active volcanoes in East Asia pose potential threats to the surrounding areas. The eruptive history of many of the Japanese volcanoes are well understood, but their dispersal pathways are often based on visible tephra. Additionally, other important volcanoes in the region still require a deeper understanding of their eruptive potential. Here, we explore the Holocene cryptotephra record preserved in a marine core 13PT‐P4 in the southwestern East Sea, in order to better reconstruct past eruptive events and their dispersal. Six widespread tephra layers are identified and correlated to their source volcanoes in S Korea (Ulleungdo), China/N Korea (Changbaishan) and Japan (Kikai), with their dispersal ranges updated. Our results rank the 13PT‐P4 sequence the most intensively tephra‐constrained Holocene record in the East Sea, which permits synchronization of this mid‐latitude archive with records in the Arctic and tropical regions. Terrestrially based tephra ages are used to constrain the marine reservoir effect and the age‐depth model of the record. The average reservoir age in the region is estimated to be 1150 ± 30 14C yr at ca. 7.3–5.6 cal ka BP and 1565 ± 30 14C yr at ca. 1.0 cal ka BP. These observed changes in reservoir age could indicate active upwelling at a regional scale. Additionally, we provide a detailed age estimate and glass geochemistry for a previously poorly understood eruption (U‐1) from the Ulleungdo volcano, thus refining its Holocene eruptive history. The U‐1 eruption is dated to 3354‐3080 cal yr BP (95.4%), and has glass composition that is distinct from other Ulleungdo tephras.
Continuous Wear of Night and Day Orthosis Is a Key Factor for Improvement of Fixed Equinus Deformity after the Transverse Vulpius Procedure

Background: Equinus foot deformity is secondary to either spasticity or contracture of the gastrocnemius–soleus complex. The plantar flexion is basically treated conservatively; several different surgical methods have been discussed. This paper focuses on the improvement of passive ankle dorsiflexion after a transverse Vulpius procedure in equinus foot deformity. Additionally, the influence of consequent postoperative wear of orthosis on the improvement of ankle range of motion was investigated. Methods: In total, 41 patients with neuromuscular impairment and 59 equinus feet deformities were surgically treated by using a transverse Vulpius procedure. A total of 19 female patients and 22 male patients with a mean age at surgery of 10.18 years (2 to 31) were included. Mean follow-up took place 12.26 ± 7.95 months after surgery. Passive ankle dorsiflexion was measured and subjective patients’ satisfaction was assessed. Results: Range of motion, measured as the maximum of passive ankle joint dorsiflexion, improved significantly from −8° ± 5.9° to 11.1° ± 6.7° directly after surgery to 16.2° ± 10.7° at follow-up. The improvement of passive ankle dorsiflexion was significantly associated with the continuous wearing of night and day orthosis (p = 0.0045). Patient subjective satisfaction was very high. Conclusion: A transverse Vulpius procedure for aponeurotic gastrocnemius and soleus muscle lengthening of equinus foot deformity resulted in a significant improvement of passive ankle dorsiflexion. Positive surgical results correlated to a continuous use of orthotic devices.
Pterygium Recurrence- Surgical and Adjuvant Therapies

Purpose: Pterygium is a prevalent disease of the eye that challenges ophthalmologists in its management due to its high tendency to reoccur. We performed an analysis to identify among the various surgical and adjuvant treatments the best combination that has the most pterygium recurrence prevention Methods: A search was run through Pubmed, Google Scholar, ClinicalTrials.gov, and World Health Organisation for Randomised control trials and other literature comparing surgical and adjuvant treatments for pterygium. This data was then analyzed to ascertain the various advantages and disadvantages of different surgeries and adjuvant therapies over each other. Results: Following the data analysis, we found out that the order of surgical methods from best to worst is as follows: Conjuctivalautograft>Amniotic membrane autograft>bare sclera. Among the adjuvant therapies studied, we found that the order of effectivity is Mitomycin C followed by anti-VEGF, radiation therapy, and finally 5 Fluorouracil. Conclusion: Bare scleral excision alone has the highest recurrence rate, followed by Amniotic Autograft and conjunctival autograft. The adjuvants that can reduce pterygium recurrences are Mitomycin C, Anti VEGF, 5-Fluorouracil, and radiation therapy with Mitomycin C, the most frequently used and with lesser late complications. More studies with larger samples and long-term follow-ups directly compare these surgical and adjuvant treatments to develop more uniform guidelines for forming treatment plans.
Offensiveness of controversial products for students of three different fields of study in Brazil

Purpose: investigate the offensiveness of controversial products in Brazil, especially the influence of the field of study. Design/methodology/approach: a questionnaire with 11 controversial products was conventionally answered by a sample of 368 college students from the three most popular fields of study in Brazil (i.e. Human Sciences, Biological and Health Sciences, and Exact and Technological Sciences). The offensiveness of each controversial product was measured and compared across those fields of study through t-tests. Findings: Controversial products did not easily offend respondents being guns, weight-loss medicine, and female underwear the most offensive ones. In general, students of Human Sciences are the most easily offended and those of Exact and Technological Sciences the least offended. In addition, results showed differences and similarities between people from each field of study. Originality/value: Improvement of our knowledge about controversial products in Brazil, especially about the influence of the field of study in the offensiveness of controversial products.
Precipitation of Calcium Phosphates and Calcium Carbonates in the Presence of Differently Charged Liposomes

Liposomes (lipid vesicles) are often considered to be a versatile tool for the synthesis of advanced materials, as they allow various control mechanisms to tune the materials’ properties. Among diverse materials, the synthesis of calcium phosphates (CaPs) and calcium carbonates (CaCO3) using liposomes has attracted particular attention in the development of novel (bio)materials and biomineralization research. However, the preparation of materials using liposomes has not yet been fully exploited. Most of the liposomes used have been anionic and/or zwitterionic, while data on the influence of cationic liposomes are limited. Therefore, the aim of this study was to investigate and compare the influence of differently charged liposomes on CaPs and CaCO3 formation. Zwitterionic 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), negatively charged 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine (DMPS), and positively charged 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (EPC) lipids were used to prepare the respective liposomes. The presence of liposomes during the spontaneous precipitation of CaPs and CaCO3 affected both the precipitation and transformation kinetics, as well as the morphology of the precipitates formed. The most prominent effect was noted for both materials in the presence of DMPS liposomes, as (nano) shell structures were formed in both cases. The obtained results indicate possible strategies to fine-tune the precipitation process of CaPs and CaCO3, which may be of interest for the production of novel materials.