Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of the potassium channels in vasorelaxant effect of asafoetida essential oil

Objective: In a previous work, we showed that asafoetida essential oil (AEO), from oleo-gum resin of Ferula asafoetida L. from the Apiaceae family, has a vasodilatory effect. This effect was both endothelium-dependent and endothelium-independent. The present study was designed to determine whether potassium channels and intracellular calcium release contribute to AEO-induced vasodilation. Materials and Methods: Rats' thoracic aorta were isolated and denuded. Following induction of contraction by potassium chloride (60 mM), concentration-response curve was plotted by the cumulative addition of AEO (0.625-80 µl/l to the medium of rings. The vasodilatory effect of AEO was assessed before and after addition of phenylephrine and potassium channel blockers (including barium chloride (BC), 4-aminopyridine (4A) and glibenclamide (Gl)). Results: AEO relaxed the precontracted rings in a concentration-dependent manner (IC50=23 µl/l). All potassium channel blockers significantly attenuated the vasodilatory activity of AEO when they were added to rings medium before addition of KCl (p<0.01, 4A and Gl groups and p< 0.001, BC group vs. control group) but not after that. In contrast to K channel blockers, adding AEO before or after phenylephrine, the tension was reduced significantly (p<0.05 vs. the control group). Conclusion: The findings of this study indicated that the vasodilatory effect of AEO on denuded-endothelium aortic ring was mediated through activation of potassium channels and reduced intracellular calcium release.
USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2

USP32, a member of the ubiquitin-specific proteases family, has been implicated in the development of breast cancer and small lung cancer. However, its biological functions and clinical significance in gastric cancer (GC) remain unclear. In the present study, we reported that knockdown or depletion of USP32 significantly inhibited GC cell proliferation and migration in vitro and in vivo, indicating that USP32 functions as an oncogene in GC. Importantly, results from immunohistochemical staining in a tissue microarray revealed that USP32 was upregulated in GC tissues compared with paracancerous tissues. Further analyses showed that high expression of USP32 was closely related with high T-staging and poor outcomes of GC patients. Mechanistically, USP32 silencing caused a decrease in the expression of SMAD2, which resulted in the inhibitory effects of GC cells on growth, motility, and chemoresistance to cisplatin. Therefore, our findings strongly suggest the involvement of USP32 in GC progression and provide a potential target for future therapy of GC.
THE IMPACT OF WHATSAPP TOWARD UAD UNDERGRADUATE STUDENTS’ BEHAVIOR IN LEARNING PROCESS

WhatsApp is one of the social media that is used to communicate in the learning process. At present, students cannot be separated from their daily activities away from this social media. This opportunity can be utilized as well as possible by the students. This research was conducted to find out of using WhatsApp toward undergraduate students’ behavior in the teaching and learning process. This study was descriptive qualitative research. The data were analyzed using descriptive analysis technique. The data were collected using interviews, observation, and documentation. The aim of this study to analyze the impact of WhatsApp toward undergraduate students’ behavior and to analyze students’ behavior in their learning process. The result of this research showed that are a positive impact on student behavior as it affects the learning process as, students’ sharing knowledge, student preparation for class, attention, student participation in class, student learning, desires to take additional classes or in subject matter and the negative impact such as, students are more focused.
FACTORS RELATING TO FALLS RISK AMONG COMMUNITY-DWELLING ELDELRY PEOPLE IN JAMBI, INDONESIA

Facing aging societies, falls risk of elderly people was an urgent public health concern leading to severe injury, decreased functioning, and mortality. Particularly susceptible was elderly people living in the community. The aim of this study was to determine factors related to falls risk among community-dwelling elderly. A descriptive correlation design was performed with 166 elderly people in Kota Jambi district. Female or male, of aged 60 years or above were interviewed at five public health centers, following the instruments; 1) Falls Risk Assessment Tools (FRAT) assessed the risk of falls and 2) Time Up and Go Test (TUGT) recorded the Physical function level among elderly people. The primary outcome was a falls risk incidence within six months. The majority (83%) of elderly people who were high risk of falls performed a fair physical function level. The results showed that age, gender, educational level, living arrangement, and occupation were not significant relationships with falls risk. However, physical function was moderately associated with falls risk among community-dwelling elderly people. The results emphasized that elderly who had a chance to improve physical function were less likely to exposure falls risk. © 2014 Pak Publishing Group. All Rights Reserved.
The effect of lycopene in egg shell membrane guidance channel on sciatic nerve regeneration in rats

Objective(s): Peripheral nerves are commonly damaged. Although the nerve autograft still subsists the gold standard in surgery of nerve injury gaps, it has severe detriment. The egg shell membrane (ESM) is a natural material, which has a great potential in practice. The aim of this survey was to appraise the effect of lycopene and the ESM nerve guidance channel on sciatic nerve regeneration. Materials and Methods: In this study, 32 male rats were randomized into four groups: sham surgery, autograft, ESM+ dimethyl sulfoxide (DMSO), and ESM+lycopene. One centimeter of sciatic nerve was removed, and the gap was grafted by ESM channel or autograft. The sciatic function index (SFI) was evaluated at days 7, 21, 30, 49, 60 and 90 after surgery. Nerve regeneration and gastroknemius muscle fibers were evaluated at days 30 and 90 after surgery by withdrawal reflex latency (WRL), histology and immunohistology assessments. Results: At 49, 60 and 90 days after surgery, the mean SFI in ESM+lycopene group was significantly greater than ESM+DMSO group (P<0.05). On day 90, the mean muscle fiber diameters and the mean number of myelinated axons in ESM+lycopene and autograft groups were significantly greater than ESM+DMSO group (P<0.05). In addition, the mean WRL was significantly lower in ESM+lycopene group than in the ESM+DMSO group 90 days after surgery (P<0.05). Conclusion: The results of this study show that the affirmative effects of ESM+lycopene may be beneficial for treating peripheral nerve damages.
Infrastructure and Local Economic Development

Investments in infrastructure have always been an issue in political discussions about future (local) economic development. Besides the overall effects of infrastructure on a country's GDP, the regional and local consequences of the latter are of special interest to policymakers. Infrastructure is generally defined by its different constituents – for example, the water and power supply, communication network, or transport infrastructure (such as road or rail) – of a region. Questions about the role of infrastructure mainly concern spatial aspects: for instance, the importance of proximity to main transport axes, or how information and communication networks can reduce physical distance are issues often addressed. In developed countries, infrastructure mainly drives the spatial economic interaction between cities, suburbs and peripheral regions. In contrast, a lack of infrastructure is one reason for the rapid urbanization of developing countries. This chapter reviews the current findings in this field. To put the literature into perspective, we utilize the case of transport infrastructure on the regional labor market development. For this, we examine the long-term effects of the German Autobahn network on regional wages and local employment structure, and look at current road investment in Germany.
Eight-Weeks Individualized Exercise Program Targeted for Patients with Crohn's Disease: A Feasibility Study

Background: Prior work suggested a positive association between self-reported disease activity and increased fat mass in patients with Crohn’s Disease on biologic therapies. Aims: To test the feasibility of a physical activity intervention protocol aimed at reducing the severity of symptoms in patients with Crohn’s Disease, including self-reported disease activity, fatigue and quality of life. Methods: The study sample included 19 of 24 recruited, biologic-experienced, patients with Crohn’s Disease with mild-to-moderate self-reported disease activity. Study participants completed patient reported outcome measures (HBI, IBD-F, EQ-5D-5L, CPSS) and body composition at baseline and after eight weeks of intervention. Intervention: In dialogue with the participant, a training consultant developed an individualized exercise program including exercise with moderate to high intensity, for the participant to follow during the course of eight weeks, including weekly phone call supervision by training consultants. Results: Patient reported measure outcomes showed a tendency for decreased self-reported disease activity, significant decrease in stress and fatigue score along with a significant increase in general wellbeing. A decrease in fat mass (p = 0.024) and increase in muscle mass (p = 0.036) was shown. Conclusion: Moderate to high intensive exercise was feasible and beneficial as a supplement to regular biologic therapy, in patients with Crohn’s Disease. This feasibility study was limited by a small sample size, and no control group, thus the set-up and results from this study may be used in the planning of future RCT studies.
EFFECT OF CULTURAL PRACTICES ON WEEDS COMMUNITY IN FUNCTION OF POTATO YIELD

In the paper are presented results of three years studies performed in the period 2008–2010 on effects of cultural practices in stands of Panico-Galinsogetum Tx. et Beck. 1942. association in conventional potato production on the experimental plots in the vicinity of Becej (Northern Serbia). Composition of association Panico-Galinsogetum in experimental control variant builds 31 weed species. From Panico-Galinsogetum community, in the variant with one cultivation (with earthing up) without herbicide applying was found 22 weed species, and at the variant with two cultivation without herbicide 17 weed species, respectively. Herbicide treatments of potato crops as well as cultivation led to significant impoverishment of the weed flora, i.e., reduction in number of weed species, their coverage value, as well as the degree of presence in potato crop. Due to reduction of weed infestation, in variants untreated by herbicides, by application of two cultivations, achieved potato yield was for 8% higher in comparison to the variant with one cultivation. In variants treated by herbicides, potato yield was for 32% higher in relation to the yield on untreated experimental variants. The average number of tubers per plant achieved in variants treated by herbicides was for 40% higher in comparison to the number of tubers in untreated variants. In both cases, in comparison to control variant, cultivation resulted in significantly higher number of tubers per plant.
Subjective Responsibility of Spanish University Teachers: A qualitative pilot study

Teacher subjective responsibility is a prominent component of teachers’ professional identity. It has a great impact on teachers’ attitudes to various aspects and ethical questions relating to their profession and thus infl uences their performance. Aims: Th e pilot study presented in this paper aimed to reveal the position of teacher subjective responsibility within the self-perceived identity of teachers and to fi nd its relations to individual ingredients of teachers’ professional identity. Th e participants in our pilot study were four Spanish university teachers preparing future primary school teachers for their careers. Methods: To gain a deeper insight into the teachers’ perception of their subjective responsibility we opted for a qualitative design and conducted semi-structured interviews. Having chosen a phenomenological approach, we concentrated on the participants’ understanding of their subjective responsibility and its eff ects. We focused on the teachers’ self-perception and inquired about the path that had led them to their profession and also about their teaching experience, searching for links connecting these to their subjective responsibility. Results: Th e research results demonstrate that our participants do feel responsible for a number of issues and they also reveal a particularly strong connection between teacher subjective responsibility and their commitment. Th e inquiry also indicated that commitment, closely interconnected with subjective responsibility, comes with a price, aff ecting the personal lives of the participants. Conclusions: Although our preliminary fi ndings are limited because of the small number of participants and the strategy of a single interview, we believe that we have taken the fi rst steps to understanding teacher subjective responsibility regarding its position within the broader context of teachers’ professional identity.
INCORPORATING CULTURAL FACTORS IN EFL CONTEXT

This study highlighted the issue of the incorporation of English cultures, cultural preference and diversity in relation to the students’ English program. The need to analyze the students’ perception is imperative since the students are considered as one of the most important factors in determining the success or failure of their own learning process. The respondents recruited for the present study were 80 part-time college students of different departments (i.e., Literature, Informatics, and Accounting). The use of mixed method aimed to elicit more elaborate data on the students’ perceptions toward the above issues. The instruments used in the present study were questionnaires and semi-structured interview. During the data collection, the questionnaire, and interview were administered within the same day. The results indicated that the students’ perception toward the incorporation of English culture was ambivalent. Of the 80 participants, there were only 48 students who voiced to agree and to strongly agree with the exposure; while the rest of the participants did not seem to agree. It was also found that most of the students preferred to learn Asian cultures instead of western ones. The most noticeable determinants affecting their preference were mainly the popularity of Asian cultures exposed on various media as well as their jobs which mostly involved Asian employers (Japanese, Korean, etc.). They were also found to appreciate the exposure conducted by the teacher as one of the relevant activity when learning foreign language. English grammar and vocabulary are skills to prioritize when speaking with Asians, and they did not find pronunciation important to support communication among them.
Multivariate characterisation of Italian monovarietal red wines using MIR spectroscopy

Aim: The aim of this study was to investigate the application of mid-infrared (MIR) spectroscopy combined with multivariate analysis, to provide a rapid screening tool for discriminating among different Italian monovarietal red wines based on the relationship between grape variety and wine composition in particular phenolic compounds.Methods and results: The MIR spectra (from 4000 to 700 cm‒1) of 110 monovarietal Italian red wines, vintage 2016, were collected and evaluated by selected multivariate data analyses, including principal component analysis (PCA), linear discriminant analysis (DA), support vector machine (SVM), and soft intelligent modelling of class analogy (SIMCA). Samples were collected directly from companies across different regions of Italy and included 11 grape varieties: Sangiovese, Nebbiolo, Aglianico, Nerello Mascalese, Primitivo, Raboso, Cannonau, Teroldego, Sagrantino, Montepulciano and Corvina. PCA showed five wavelengths that mainly contributed to the PC1, including a much-closed peak at 1043 cm‒1, which correspond to the C–O stretch absorption bands that are important regions for glycerol, whereas the ethanol peaks at around 1085 cm‒1. The band at 877 cm‒1 are related to the C–C stretching vibration of organic molecules, whereas the asymmetric stretching for C–O in the aromatic –OH group of polyphenols is within spectral regions from 1050 to 1165 cm‒1. In particular, the (1175)–1100–1060 cm‒1 vibrational bands are combination bands, involving C–O stretching and O–H deformation of phenolic rings. The 1166–1168 cm‒1 peak is attributable to in-plane bending deformations of C–H and C–O groups of polyphenols, respectively, for which polymerisation may cause a slight peak shift due to the formation of H-bridges.The best result was obtained with the SVM, which achieved an overall correct classification for up to 72.2% of the training set, and 44.4% for the validation set of wines, respectively. The Sangiovese wines (n=19) were split into two sub-groups (Sang-Romagna, n=12 and Sang-Tuscany, n=7) considering the indeterminacy of its origins, which is disputed between Romagna and Tuscany. Although the classification of three grape varieties was problematic (Nerello Mascalese, Raboso and Primitivo), the remaining wines were almost correctly assigned to their actual classes.Conclusions: MIR spectroscopy coupled with chemometrics represents an interesting approach for the classification of monovarietal Italian red wines, which is important in quality control and authenticity monitoring.Significance and impact of the study: Authenticity is a main issue in winemaking in terms of quality evaluation and adulteration, in particular for origin certified/protected wines, for which the added marketing value is related to the link of grape variety with the area of origin. This study is part of the D-wine project “The diversity of tannins in Italian red wines”.
Environmental Factors and Affective Well-Being Influence on Mine Workers Absenteeism in South Africa

Human resources remain the most important and valuable assets of every organisation. In effect, the strategic monitoring and management of related environmental factors and employees’ affective well-being for continued presence at work are becoming increasingly fundamental. The mining industry is characterised with different environmental factors and affective well-being puzzle that may likely affect employees’ turnaround time at work. While available studies have largely investigated how environmental factors predict employee’s well-being, what is unclear is how environmental factors and affective well-being determines employee’s absenteeism from work. Using a quantitative study, this study examines how environmental factors and affective well-being influence workers absenteeism in South African mine industry. A total of 280 mineworkers were randomly selected using a descriptive survey of the probability sampling technique. The retrieved data were analysed using both the simple and multivariate regression analysis. The findings revealed that both environmental factors and affective well-being do not predict mine workers absenteeism, although environmental factors show more variation in employee’s absenteeism than affective well-being. Similarly, the different environmental factors including exposure to noise, dust, vibration, temperature and heavy lifting do not show any evidence to have predicted mine workers turnaround time at work, except hazardous materials. The study concludes that mitigating the consequence provoked by hazardous materials on mine workers will significantly increase employees’ presence at work. Thus, the study makes a case for the revitalisation of the South African mining industry, especially in the area of setting out modalities for the control of strenuous environmental factors, particularly hazardous materials in the workplace.
In patients with clinically stable rheumatoid arthritis (clinical remission), can musculoskeletal ultrasound in addition to clinical examination detect or rule out inflammation that predicts subsequent joint damage to inform tapering and discontinuation of therapy?

Evidence notes are rapid reviews of published secondary clinical and cost-effectiveness evidence on health technologies under consideration by decision makers within NHSScotland. They are intended to provide information quickly to support time-sensitive decisions. Information is available to the topic referrer within a 6-month period and the process of peer review and final publication of the associated advice is usually complete within 6–12 months. Evidence notes are not comprehensive systematic reviews. They are based on the best evidence that Healthcare Improvement Scotland could identify and retrieve within the time available. The draft evidence notes are subject to peer review. Evidence notes do not make recommendations for NHSScotland, however the Scottish Health Technologies Group (SHTG) produces an Advice Statement to accompany all evidence reviews.
Method of measuring the effort related to post-editing machine translated outputs produced in the English>Polish language pair by Google, Microsoft and DeepL MT engines: A pilot study

This article presents the methodology and results of a pilot study concerning the impact of three popular and widely accessible machine translation engines (developed by Google, Microsoft and DeepL companies) on the pace of post-editing work and on the general effort related to post-editing of raw MT outputs. Fourteen volunteers were asked to translate and post-edit two source texts of similar characters and levels of complexity. The results of their work were collected and compared to develop a set of quantitative and qualitative data, which was later used to make assumptions related to the general rate of postediting work and the quality of the post-edited sentences produced by the subjects. The aim of the pilot study described below was to determine whether the applied method can be successfully used in more profound studies on the quality and impact of machine translation in the English->Polish language pair and on the potential of MT solutions on the Polish translation market.