Miracle-dz/UniFAR-FTUs huggingface dataset:
A Personal Prospective on Testosterone Therapy in Women—What We Know in 2022

Hormone replacement therapy continues to be a controversial topic in medicine, with certain narratives regarding safety concerns that are not scientifically established in peer-reviewed literature. These negative narratives, specifically undermining the use of testosterone in women, have caused women to remain without any Food and Drug Administration (FDA)-approved testosterone therapies, while more than 30 FDA-approved testosterone therapies are available for men in the United States. This has resulted in millions of women suffering in silence with very common symptoms of perimenopause and menopause that could easily be addressed with the use of testosterone. There is growing evidence to support the use of physiologic doses of testosterone for sexual function, osteoporosis prevention, brain protection, and breast protection. The safety of testosterone use in women has been evaluated for the past 80 years. A recent publication on the complications of subcutaneous hormone-pellet therapy, looking at a large cohort of patients over 7 years, demonstrated long-term safety. In addition, there have been two large long-term peer-reviewed studies showing a significant reduction in the incidence of invasive breast cancer in women on testosterone therapy. Perhaps it is time for the FDA to consider approving products that would benefit testosterone-deficient women.
Effects of run‐of‐the‐river hydropower plants on the surface water quality in the Solakli stream watershed, Northeastern Turkey

In recent years, Turkey has turned its attention to alternative energy sources rather than fossil fuels. The Eastern Black Sea Region of Turkey has steep mountains with hilly topography and has large potential in terms of energy production with run‐of‐the‐river hydropower plants (RHPPs). In this study, the effects of two RHPPs on some water quality parameters were examined in the Solaklı stream watershed. This research was conducted over the course of 12 months (January–December 2014). In total, 12 sampling points were selected and various water quality parameters, such as temperature, pH, dissolved oxygen, total suspended solids, electrical conductivity, total dissolved solid, chloride and salinity, were monitered at each point. Statistically, significant changes occured in water quality parameters such as total suspended solids, pH and temperature. In particular, total suspended solids ranged from 10 to 440 mg/L.These results suggest that the RHPP negatively effect water quality and quantity in the main stream in both the operational and constructional phases.
EFFECT OF ACETYLATION ON TECHNOLOGICAL CHARACTERISTICS OF Jacaranda copaia WOOD: PART 2 – CHEMICAL AND COLORIMETRIC CHANGES

ABSTRACT: Acetylation is a chemical change to improve wood properties through a chemical reaction that substitutes hydroxyl with acetyl groups. Thus, the objective of this work was to assess the efficiency of acetylation for the improvement of Jacaranda copaia wood properties. Chemical characterization, infrared spectroscopy, and colorimetry tests were carried out. The infrared spectra were qualitatively analyzed for chemical changes caused by acetylation. Changes in wood color parameters (L*, a*, b*, C, and h*) were evaluated. The wood acetylation was carried out through immersion of samples in anhydride acetic; 5 treatments were evaluated: Control (no acetylation), acetylation for 2 hours, acetylation for 4 hours, acetylation for 6 hours, and acetylation for 8 hours. All reactions were carried out under a constant temperature of 90±2 °C. The results showed the occurrence of chemical changes in structural components of the acetylated wood by increases in 1735, 1375, and 1250 cm bands referring to the addition of acetate groups. Regarding colorimetry, darkening of wood was found for all acetylation treatments. Keywords: Amazon wood; surface properties; color; FTIR. Efeito da acetilação nas propriedades tecnológicas da madeira de Jacaranda copaia: Parte 2 – alterações químicas e colorimétricas RESUMO: A acetilação é uma modificação química que visa a melhoria das propriedades da madeira a partir de uma reação química que substitui um grupo hidroxila por um grupo acetil. Assim, este trabalho teve como objetivo comprovar a eficiência da acetilação na melhoria das propriedades da madeira de Jacaranda copaia. Para isso, foram realizados a caracterização química, testes de espectroscopia na região do infravermelho e testes de colorimetria. Buscou-se por meio dos espectros de infravermelho uma análise qualitativa das modificações químicas proporcionadas pela acetilação. Adicionalmente, foram avaliadas as alterações proporcionadas na coloração da madeira (parâmetros L*, a*, b*, C e h*). A acetilação da madeira foi realizada mediante imersão de amostras em anidrido acético, sendo avaliados 5 tratamentos: Controle (não acetiladas), Acetilação por 2 h, Acetilação por 4 h, Acetilação por 6 h e Acetilação por 8 h. Todas as reações realizadas com a temperatura constante de 90 ± 2°C. Os resultados evidenciaram que ocorreu uma modificação química nos componentes estruturais da madeira acetilada, por meio do aumento nas bandas 1735, 1375 e 1250 cm-1 referentes a adição de grupos acetatos. Em relação à colorimetria verificou-se o escurecimento da madeira acetilada em todos os tratamentos. Palavras-chave: Madeiras da Amazônia; propriedades de superfície; cor; FTIR.
Free School Meal Improves Educational Health and the Learning Environment in a Small Municipality in Norway

It has been suggested that school meals could have an impact on students’ learning environments; however, existing research in this field is scarce and inconclusive. The purpose of this study was to explore teachers’ and school administrators’ experiences with the introduction of a free school meal and whether this influenced the learning environment. The study was conducted in upper primary and lower secondary schools in a small municipality in Norway. In this qualitative study, 17 informants participated in semi-structured in-depth interviews. The interviews were recorded, transcribed, and coded using NVivo. Thematic analysis was conducted using systematic text condensation (STC). The main findings are that in the informants’ experience, a free school meal led to reduced absenteeism during lunchtime and positive social interactions among students, social equalization, and a more peaceful atmosphere during lunchtime. In conclusion, the introduction of a free school meal had a positive impact on the students’ educational health and the learning environment, and contributed to social equalization as all the students shared the same healthy school meal.
Influence of the Anisotropic Behavior on Equibiaxial Paths

Marciniak and Nakajima tests are commonly used in building FLD's, since they allow covering all regions from uniaxial to almost equibiaxial strain paths. In this work, the deviation from equibiaxial strain paths is analyzed as function of the material anisotropic behavior. The numerical results show that material with present equibiaxial stress and strain paths, while for the ones with the paths are neither equibiaxial in stress nor strain. Moreover, it is shown that despite the similarities between the two tests, they present different sensitivity to the control of the blank holder force and to the friction coefficient. Namely, the stress and strain paths in the Marciniak specimen center are more sensitive to the control of the blank holder force. On the other hand, the stress and strain paths in the Nakajima specimen center are more sensitive to the friction coefficient. The deviation from the equibiaxial strain path indicates that the stress ratio is also not necessarily 1.0, meaning that the stress triaxiality and the Lode parameter also present some deviation from the reference values for an equibiaxial stress state. This should be taken into account when analyzing forming limit results.
Increase in Referrals of Children and Adolescents to the Psychiatric Emergency Room Is Evident Only in the Second Year of the COVID-19 Pandemic—Evaluating 9156 Visits from 2010 through 2021 in a Single Psychiatric Emergency Room

Introduction: The COVID-19 pandemic affected the wellbeing of children and adolescents. The psychiatric emergency room (ER) is the hub of psychiatric emergencies and reflects clinically significant mental problems. Previous studies compared 2019 and 2020 and observed a decline in ER referrals. The current study focused on the continuous trend of referrals from 2010 to the end of 2021. Method: In our observational retrospective study, we procured data from 9156 child and adolescent referrals to our psychiatric ER. The comparison was made based on similar months of each year. Results: There was a significant positive trend in monthly referrals between 2010 and 2021, representing a similar increase in referrals per month in comparison to that month in the preceding year (unstandardized β = 4.21, 95% CI = 3.44 to 4.98, p < 0.0001). Between March 2020 and February 2021 (monthly visits = 72.5 + 16.6 [median = 79.5], annual referrals = 870), we observed no additive effect beyond this general trend after controlling for population growth. Conversely, between March and December 2021 (monthly referrals = 106.1 + 31.8 [median = 105.5], overall referrals = 1061) we observed a significant additive effect beyond the projected incline, as predicted by previous years (β = 21.61, 95% CI = 12.12 to 31.06, p < 0.0001). Conclusions: The first year of the COVID-19 pandemic was no different from the continuous decade long rise of referrals to the children and adolescents’ psychiatric ER. Conversely, the second year showed an additional incline beyond the general trend. The complexity in this rising need demands the awareness of clinicians and policy makers alike.
Determining Tropical Cyclone Center and Rainband Size in Geostationary Satellite Imagery

Brightness temperature (TB) observations at an infrared channel (10.3 μm) of the Advanced Baseline Imager (ABI) on board the U. S. 16th Geostationary Operational Environmental Satellite (GOES-16) are used for determining tropical cyclone (TC) center positions and rainband sizes. Firstly, an azimuthal spectral analysis method is employed to obtain an azimuthally symmetric center of a TC. Then, inner and outer rainbands radii, denoted as RIR and ROR, respectively, are estimated based on radial gradients of TB observations at different azimuthal angles. The radius RIR describes the size of the TC inner-core region, and the radius ROR reflects the maximum radial extent of TC rainbands. Compared with the best track centers, the root mean square differences of ABI-determined centers for tropical storms and hurricanes, which totals 108 samples, are 45.35 and 29.06 km, respectively. The larger the average wavenumber-0 amplitude, the smaller the difference between the ABI-determined center and the best track center. The TB-determined RIR is close but not identical to the radius of the outermost closed isobar and usually coincides with the radius where the strongest wavenumber 1 asymmetry is located. The annulus defined by the two circles with radii of ROR and RIR is the asymmetric area of rainbands described by azimuthal wavenumbers 1–3. In general, amplitudes of wavenumber 0 component centered on the ABI-determined center are greater than or equal to those from the best track. For a case of a 60 km distance between the ABI-determined and the best track TC center, the innermost azimuthal waves of wavenumbers 1–3 are nicely distributed along or within the radial distance RIR that is determined based on the ABI-determined TC center. If RIR is determined based on the best track, the azimuthal waves of wavenumbers 1–3 are found at several radial distances that are smaller than RIR. The TC center positions, and rainband size radii are important for many applications, including specification of a bogus vortex for hurricane initialization and verification of propagation mechanism of vortex Rossby waves.
Stoichiometric Variation in Soil Carbon, Nitrogen, and Phosphorus Following Cropland Conversion to Forest in Southwest China

Soil organic carbon (SOC), nitrogen (N), and phosphorus (P) are three essential soil nutrients for plant growth, and their stoichiometric ratios are already important indices of elemental balance and the soil fertility status in soil ecosystems. The evolution mechanism of the SOC, Total Nitrogen (TN), Total Phosphorus (TP), and stoichiometry following the “conversion of cropland to forest program” (CCFP) in southwest China is not yet clear. Seven different CCFP restoration models, including Zenia insignis (RD), Toona sinensis (XC), Castanea mollissima (BL), Citrus reticulate (GJ), Zenia insignis and Guimu-1 elephant grass (RG), Guimu-1 elephant grass (GM), and abandoned cropland (LH), were chosen to explore changes in the concentration and stoichiometry of the SOC, TN, and TP, and their recovery times, at a depth of 0–100 cm. The results indicate that the SOC and TN concentrations in different restoration models all increased with restoration years in the topsoil, whereas the soil TP concentration remained relatively stable. The soil C:N and C:P ratios increased with increasing restoration years in the topsoil, whereas the N: P ratio was relatively stable over time. After ten years of reforestation, the SOC and TN concentrations decreased as the soil layer increased. The effects of the restoration model on the C: N ratios were greater in shallow soils. Our results suggest a complex reaction of SOC, soil TN, and soil TP concentrations and stoichiometry to the vegetation restoration mode, particularly in the topsoil. This research further improves the understanding of SOC, N, and P interactions and restricted nutrition, and provides relevant theoretical support for vegetation restoration in the southwest karst region.
A 72GS/s, 8-bit DAC-based Wireline Transmitter in 4nm FinFET CMOS for 200+Gb/s Serial Links

A DAC-based SST transmitter for wireline applications is reported in a 4nm FinFET technology. 8b resolution and high analog output bandwidth (BW) are achieved by employing a segmented architecture along with a single-ended LSB. Hybrid analog/digital tuning is used in the DAC LSB segments, resulting in well-matched MSB/LSB segments with -0.63/0.67 LSB INL and -0.16/0.43 LSB DNL. 216Gb/s PAM8 and 212Gb/s QAM64 OFDM operation are demonstrated at 288mW from a 0.95V supply.
Response to the reviews on “Toward enhanced capability for detecting and predicting dust events in the Western United States: the Arizona Case Study” Huang 2015

Huang et al. are presenting on research that hits almost every item in the scope of ACP: chemical and physical processes using atmospheric modelling, field measurements, and remote sensing. The title clearly presents the contents of the manuscript with the subject matter of better detecting and predicting dust events being highly relevant in the scientific community today and highly needed to mitigate the deleterious societal impacts. The authors combine a multitude of relevant observational datasets available to the community to present the novel approach of improved prediction. The authors’ navigation through the different datasets was a little hard to follow at times but the presentation of the comparison between datasets and overall thoughts on inconsistencies with supported literature is helpful. The information on the data, methods, results and supplemental datasets provide the necessary path for other scientists to perform similar work. While as a reader, I wanted more out of the conclusions and suggestions, I believe this is more a reflection on the need for improvement in this research area than a lack in significance of the manuscript and the combination of these datasets available to the community is a novel and possibly necessary approach well illustrated in the results.
The FU Orionis Outburst as a Thermal Accretion Event

The results of the time-dependent disk models developed in Bell & Lin are compared with observed properties of FU Orionis variables. Specific models are fit to the light curves of Fu Ori, V1515 Cyg, and V1057 Cyg. The slow risetime of V1515 Cyg can be matched by a self-regulated outburst model. The rapid risetimes of FU Ori and V1057 Cyg can be fitted with the application of modest perturbations to the disk surface density. Model disks display spectral features characteristic of observed objects. The color evolution of V1057 Cyg is naturally explained if mass flux drops in the inner disk (r less than 1/4 AU) while remaining steady in the outer disk. The decrease in optical line width (rotational velocity) observed during the decay of V1057 Cyg may be accounted for by an outward-propagating ionization front. We predict that before final decay to the quiescent phase, short-wavelength line widths (lambda less than 1.5 microns) will again increase. It is suggested that FU Orionis outbursts primarily occur to systems during the embedded phase with ages less than several times 10(exp 5) yr.
The impact of Persuasion knowledge cues on social media engagement: a look at pet influencer marketing

ABSTRACT With influencer marketing expenditures set to exceed $16 billion in 2022, pet influencers are leveraging their entertaining content to capitalize on this growing market. Utilizing a dataset of 557 posts from 37 pet influencers, we apply Uses and Gratifications Theory and Persuasion Knowledge to suggest textual and visual cues within sponsored posts are capable of disrupting engagement behaviors when consumers are seeking entertainment. We find evidence that sponsorship disclosures, mentions of money, brand logos, and overall saturation of sponsorship content reduce engagement. Our findings offer insights for brands seeking to create content that generates higher levels of engagement.
Resolving the Peak of the Black Hole Mass Spectrum

Gravitational-wave (GW) detections of binary black hole (BH) mergers have begun to sample the cosmic BH mass distribution. The evolution of single stellar cores predicts a gap in the BH mass distribution due to pair-instability supernovae (PISNe). Determining the upper and lower edges of the BH mass gap can be useful for interpreting GW detections of merging BHs. We use MESA to evolve single, nonrotating, massive helium cores with a metallicity of Z = 10−5, until they either collapse to form a BH or explode as a PISN, without leaving a compact remnant. We calculate the boundaries of the lower BH mass gap for S-factors in the range S(300 keV) = (77,203) keV b, corresponding to the ±3σ uncertainty in our high-resolution tabulated 12C(α,γ)16O reaction rate probability distribution function. We extensively test temporal and spatial resolutions for resolving the theoretical peak of the BH mass spectrum across the BH mass gap. We explore the convergence with respect to convective mixing and nuclear burning, finding that significant time resolution is needed to achieve convergence. We also test adopting a minimum diffusion coefficient to help lower-resolution models reach convergence. We establish a new lower edge of the upper mass gap as M lower ≃ 60−14+32 M ⊙ from the ±3σ uncertainty in the 12C(α, γ)16O rate. We explore the effect of a larger 3α rate on the lower edge of the upper mass gap, finding M lower ≃ 69−18+34 M ⊙. We compare our results with BHs reported in the Gravitational-Wave Transient Catalog.
Gene Expression and Production of the Monokine Induced by IFN-γ (MIG), IFN-Inducible T Cell α Chemoattractant (I-TAC), and IFN-γ-Inducible Protein-10 (IP-10) Chemokines by Human Neutrophils

Monokine induced by IFN-γ (MIG), IFN-inducible T cell α chemoattractant (I-TAC), and IFN-γ-inducible protein of 10 kDa (IP-10) are related members of the CXC chemokine subfamily that bind to a common receptor, CXCR3, and that are produced by different cell types in response to IFN-γ. We have recently reported that human polymorphonuclear neutrophils (PMN) have the capacity to release IP-10. Herein, we show that PMN also have the ability to produce MIG and to express I-TAC mRNA in response to IFN-γ in combination with either TNF-α or LPS. While IFN-γ, alone or in association with agonists such as fMLP, IL-8, granulocyte (G)-CSF and granulocyte-macrophage (GM)-CSF, failed to influence MIG, IP-10, and I-TAC gene expression, IFN-α, in combination with TNF-α, LPS, or IL-1β, resulted in a considerable induction of IP-10 release by neutrophils. Furthermore, IL-10 and IL-4 significantly suppressed the expression of MIG, IP-10, and I-TAC mRNA and the extracellular production of MIG and IP-10 in neutrophils stimulated with IFN-γ plus either LPS or TNF-α. Finally, supernatants harvested from stimulated PMN induced migration and rapid integrin-dependent adhesion of CXCR3-expressing lymphocytes; these activities were significantly reduced by neutralizing anti-MIG and anti-IP-10 Abs, suggesting that they were mediated by MIG and IP-10 present in the supernatants. Since MIG, IP-10, and I-TAC are potent chemoattractants for NK cells and Th1 lymphocytes, the ability of neutrophils to produce these chemokines might contribute not only to the progression and evolution of the inflammatory response, but also to the regulation of the immune response.
Use of Autoreactive Antibodies in Blood of Patients with Pancreatic Intraductal Papillary Mucinous Neoplasms (IPMN) for Grade Distinction and Detection of Malignancy

Simple Summary Risk stratification via biomarkers used with imaging could support predicting high-risk pancreatic intraductal papillary mucinous neoplasms (IPMN) with malignant potential. We explored the presence of autoreactive antibodies in the blood of patients with IPMN of different grades of dysplasia, including IPMN with associated invasive carcinoma and early-stage pancreatic ductal adenocarcinoma (PDAC), to identify signatures of early malignancy. Multivariate predictive models retained 14 proteins as potential biomarkers for discrimination between all disease classes. The integration of the autoreactive-antibody panel with clinical variables may aid in risk stratification of high-risk IPMN patients, which would subsequently improve clinical management. Abstract (1) Background: A reliable non-invasive distinction between low- and high-risk pancreatic intraductal papillary mucinous neoplasms (IPMN) is needed to effectively detect IPMN with malignant potential. This would improve preventative care and reduce the risk of developing pancreatic cancer and overtreatment. The present study aimed at exploring the presence of autoreactive antibodies in the blood of patients with IPMN of various grades of dysplasia. (2) Methods: A single-center cohort was studied composed of 378 serum samples from patients with low-grade IPMN (n = 91), high-grade IPMN (n = 66), IPMN with associated invasive cancer (n = 30), pancreatic ductal adenocarcinoma (PDAC) stages T1 (n = 24) and T2 (n = 113), and healthy controls (n = 54). A 249 full-length recombinant human protein microarray was used for profiling the serum samples. (3) Results: 14 proteins were identified as potential biomarkers for grade distinction in IPMN, yielding high specificity but mediocre sensitivity. (4) Conclusions: The identified autoantibodies are potential biomarkers that may assist in the detection of malignancy in IPMN patients.