Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrated weed management in chickpea

Chickpea (Cicer arietinum L.) is the predominant crop among pulses in Madhya Pradesh occupying an area of 2722.36 thousand hectares with production of 3321.09 thousand tonnes and productivity 1.22 t/ha. Infestation of weeds is one of the major causes of poor productivity of chickpea. It is a poor competitor of weeds because of slow growth rate and limited leaf area development at early stages. Kumar et al. (2014) reported that presence of weeds throughout crop season reduced the seed yield of chickpea up to 68%. The predominant methods of weed control by mechanical hoeing and manual weeding over extensive scale have been declined because of shifting the agricultural labourers to industries for better and assured wages. The current trend and future development of intensive agriculture are likely to seek the help of chemicals as an effective weed control measures and replace the conventional method of weed control. Unfortunately till now, majority of the farmers are quite ignorant about the use of herbicides in chickpea. Mulching is also a good option to conserve moisture and reduce weeds. Mulch is used to cover soil surface around the plants to create congenial condition for the growth, reduce salinity and weeds (Bhardwaj 2013). The present experiment was aimed to find out the effective weed management practices for weed management in chickpea.
Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis

Progressive immune dysfunction associated with aging is known as immunosenescence. The age-related deterioration of immune function is accompanied by chronic inflammation and microenvironment changes. Immunosenescence can affect both innate and acquired immunity. Sepsis is a systemic inflammatory response that affects parenchymal organs, such as the respiratory system, cardiovascular system, liver, urinary system, and central nervous system, according to the sequential organ failure assessment (SOFA). The initial immune response is characterized by an excess release of inflammatory factors, followed by persistent immune paralysis. Moreover, immunosenescence was found to complement the severity of the immune disorder following sepsis. Furthermore, the immune characteristics associated with sepsis include lymphocytopenia, thymus degeneration, and immunosuppressive cell proliferation, which are very similar to the characteristics of immunosenescence. Therefore, an in-depth understanding of immunosenescence after sepsis and its subsequent effects on the organs may contribute to the development of promising therapeutic strategies. This paper focuses on the characteristics of immunosenescence after sepsis and rigorously analyzes the possible underlying mechanism of action. Based on several recent studies, we summarized the relationship between immunosenescence and sepsis-related organs. We believe that the association between immunosenescence and parenchymal organs might be able to explain the delayed consequences associated with sepsis.
Extremity compartment syndrome: A review with a focus on non-invasive methods of diagnosis

The article deals with an overview of acute extremity compartment syndrome with a focus on the option of non-invasive detection of the syndrome. Acute extremity compartment syndrome (ECS) is an urgent complication that occurs most often in fractures or high-energy injuries. There is still no reliable method for detecting ECS. The only objective measurement method used in clinical practice is an invasive measurement of intramuscular pressure (IMP). The purpose of this paper is to summarize the current state of research into non-invasive measurement methods that could allow simple and reliable continuous monitoring of patients at risk of developing ECS. Clinical trials are currently underway to verify the suitability of the most studied method, near-infrared spectroscopy (NIRS), which is a method for measuring the local oxygenation of muscle compartments. Less explored methods include the use of ultrasound, ultrasound elastography, bioimpedance measurements, and quantitative tissue hardness measurements. Finding a suitable method for continuous non-invasive monitoring of the syndrome would greatly improve the quality of care for patients at risk. ECS must be diagnosed quickly and accurately to prevent irreversible tissue damage that can occur within hours of syndrome onset and may even warrant amputation if neglected.
Styrylpyrone Derivative (SPD) Extracted from Goniothalamus umbrosus Binds to Dengue Virus Serotype-2 Envelope Protein and Inhibits Early Stage of Virus Replication

A study was conducted to investigate the anti-viral effect of a styrylpyrone derivative (SPD) called goniothalamin and the effects on the dengue virus serotype 2 (DENV-2) replication cycle. The SPD was prepared from the root of Goniothalamus umbrosus after purification with petroleum ether. The isolated SPD was then subjected to gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) analyses for structure validation. The cytotoxicity of the SPD was evaluated using a cell viability assay, while the anti-viral activity of the SPD towards DENV-2 was confirmed by conducting a foci reduction assay which involved virus yield reduction, time-of-addition, and time removal assays. Transcriptomic analysis via quantitative real-time polymerase chain reaction (qRT-PCR) using the DENV-2 E gene was conducted to investigate the level of gene transcript. Immunocytochemistry analysis was used to investigate the effects of SPD treatment on protein E expression. Finally, software molecular docking of the SPD and E protein was also performed. The cytotoxicity assay confirmed that the SPD was not toxic to Vero cells, even at the highest concentration tested. In the time-of-addition assay, more than 80% foci reduction was observed when SPDs were administered at 2 h post-infection (hpi), and the reduction percentage then dropped with the delay of the treatment time, suggesting the inhibition of the early replication cycle. However, the time removal assay showed that more than 80% reduction could only be observed after 96 h post-treatment with the SPD. Treatment with the SPD reduced the progeny infectivity when treated for 24 h and was dose-dependent. The result showed that transcript level of the E gene in infected cells treated with the SPD was reduced compared to infected cells without treatment. In immunocytochemistry analysis, the DENV-2 E protein exhibited similar expression trends, shown by the gene transcription level. Molecular docking showed that the SPD can interact with E protein through hydrogen bonds and other interactions. Overall, this study showed that SPDs have the potential to be anti-DENV-2 via a reduction in viral progeny infectivity and a reduction in the expression of the DENV-2 E gene and protein at different phases of viral replication. SPDs should be further researched to be developed into an effective anti-viral treatment, particularly for early-phase dengue viral infection.
Experimentation, learning, and dialogue: an RRI-inspired approach to dual-use of concern

ResponsibleResearchandInnovationispromotedbyresearchfundersandscienti ﬁ c communities as a way to place societal needs and values at the centre of research and innovation. In practice, however, legal compliance still tends to dominate the RRI agenda. In order to move beyond the dominance of legal compliance and address a broader societal agenda, this article argues that RRI requires: (1) a productive intertwining of research and practice; (2) the integration of anticipation, re ﬂ ection, engagement, and action (AREA) in a non-linear process; and (3) an experimental approach. Based on this framework, this article draws on our experience of developing and institutionalizing an RRI-inspired approach to address dual-use and misuse issues in the EU-funded Human Brain Project. Our experience suggests that the four dimensions of the AREA framework work better not as separate stages but rather being ﬂ exibly intertwined to enable experimentation, learning, and dialogue.
Automatic Information Model Generation for Industrial Edge Applications Based on IEC 61499 and OPC UA

The Industry 4.0 and Industrial Internet provides vertical and horizontal integration between edge devices and industrial cloud platforms. A flexible and interoperable information model is crucial for enabling device-level intelligence as well as cloud-edge collaboration. Deep integration between the control and information model is necessary for supporting closed-loop optimization between the cloud and edge devices. This article proposes an automatic information model generation method based on the IEC 61499 and OPC unified architecture standards. Model transformation rules between two models from design time to runtime are presented. A discrete manufacturing case study is used to prove that the proposed method can significantly reduce the development time for distributed information models. The integrated control and information models at runtime can provide strong support for dynamic reconfiguration to address changing requirements.
Evaluation of the effects of fluoride mouth rinse and varnish on the early biofilm formation of Streptococcus mutans in two types of orthodontic adhesive resins: An in vitro study

Background: The aim of the present study is to compare the antibacterial effect of fluoride mouth rinse and fluoride varnish on the primary biofilm formation of Streptococcus mutans (S. mutans) in two types of orthodontic adhesives. Materials and Methods: This is an in vitro study in which forty composite discs of Transbond XT and Lightbond were divided randomly into 4 groups: Group 1: Control group (not treated with fluoride), Group 2: Rinsed by 0.2% fluoride mouth rinse, Group 3: Rinsed by 0.05% fluoride mouth rinse, and Group 4: Treated by varnish fluoride. Then each group was placed in S. mutans suspension. Bacterial suspension from each treatment was subcultured onto the surface of Mueller–Hinton agar plates, and bacterial growth was assessed. The results were analyzed by analysis of variance test and Scheffé test was run to compute the binary groups (P < 0.05). Results: There was a statistically significant reduction in the viability of S. mutans in treated groups by fluoride but no significant difference between two types of composites. Conclusion: The results of this study demonstrated that S. mutans colonies were sensitive to fluoride and their most effective form was varnish. There was no significant difference in early biofilm formation of S. mutans in two types of orthodontic adhesive resins Transbond XT and Lightbond.
Perceived employability of skilled migrants: a systematic review and future research agenda

Abstract This review examines the perceived employability of skilled migrants (SMs) through an analysis of 88 management and organisational research articles published over 2009-2019 period. We find the extant literature characterised by context-specific studies featuring considerable variety in terms of levels of analysis, theory, and content. Using the notion of perceived employability, key themes in the literature are identified and presented in an integrative framework. The framework encompasses individual, organisational, occupational, and institutional components of the perceived employability of SMs, different forms of work transition and associated mediators (broadening strategies) and moderators (transition conditions). Proposing adoption of process thinking for future research, suggestions regarding the interaction of individual and contextual components of perceived employability and the mediation and moderation mechanisms in the process of work transition are outlined.
A Conflict-Driven Interface Between Symbolic Planning and Nonlinear Constraint Solving

Robotic planning in real-world scenarios typically requires joint optimization of logic and continuous variables. A core challenge to combine the strengths of logic planners and continuous solvers is the design of an efficient interface that informs the logical search about continuous infeasibilities. In this paper we present a novel iterative algorithm that connects logic planning with nonlinear optimization through a bidirectional interface, achieved by the detection of minimal subsets of nonlinear constraints that are infeasible. The algorithm continuously builds a database of graphs that represent (in)feasible subsets of continuous variables and constraints, and encodes this knowledge in the logical description. As a foundation for this algorithm, we introduce Planning with Nonlinear Transition Constraints (PNTC), a novel planning formulation that clarifies the exact assumptions our algorithm requires and can be applied to model Task and Motion Planning (TAMP) efficiently. Our experimental results show that our framework significantly outperforms alternative optimization-based approaches for TAMP.
National Chronic Disease Management Programmes in Irish General Practice-Preparedness and Challenges

Information on the readiness of Irish general practice to participate in structured chronic disease management (CDM) care is limited. This study explores the logistic, staffing, and organizational preparedness of Irish general practice to do so, stratified by their size, location, and training status; implementation challenges were also explored. An anonymous, paper-based random survey was performed. A chi-square test was applied to compare practices by location (urban/rural), post-graduate training status (with/without), and numbers of GMS patient (≥1500/>1500 patients) and prevalence ratio and Poisson regression analysis to examine the relationship of staffing with key variables. Overall, 125/243 practices participated, 22% were rural, 56.6% were post-graduate training practices, and 53.9% had ≥1500 GMS patients. The rural, non-training practices and those with <1500 GMS patients had substantially lower staffing levels. The average number of GPs was significantly less in rural practices; however, the difference was insignificant for nurses. Salary costs for practice nurses in all practices and staff IT training and clinical equipment in smaller practices were important barriers. Most practices reported ‘inadequate’ waiting times for access to almost all referral and paramedical services. The study recommends addressing the staffing, funding, and training challenges within Irish general practice to effectively implement a structured CDM program.
Use of Sonophoresis with Corticosteroids in Carpal Tunnel Syndrome: Systematic Review and Meta-Analysis

Carpal tunnel syndrome is a neuropathic disease. It is one of the most frequent musculoskeletal pathologies affecting the upper limbs. One of most frequently used non-surgical treatments is corticosteorids. There are several alternatives for corticosteroids administration. One of them is phonophoresis, this being an effective and painless method of treatment. A systematic review and meta-analysis have been conducted over the use of phonophoresis with corticosteroids for the treatment of carpal tunnel syndrome compared to other non-surgical treatment methods. Keywords from Medical Subjects Headings (MeSH) were used in the following databases: Wos, Scopus, CINHAL, SciELO and PeDro. A total of 222 potentially relevant articles were retrieved. Eleven articles analysing the efficacy of phonophoresis with corticosteroids in reducing pain symptoms in individuals with carpal tunnel syndrome were included, 10 of which were used to conduct the meta-analysis. A conclusion could not be reached as to the application of phonophoresis with corticosteroids being better than other treatment methods, except for the perception of pain and an improved motor and sensory nerve conduction in cases of mild to moderate carpal tunnel syndrome.
A Finite Element Model for the Instability Analysis of Flexible Pipes Tensile Armor Wires

The instability of the tensile armor wire of flexible pipes is a failure mode associated with deep and ultra-deep water applications. Real compressive forces acting on the pipe are necessary to trigger this process. The loss of stability may be divided into two distinct processes, according to the main direction of the wire’s displacement: radial or lateral instability. This study aims at proposing a numerical tool for predicting lateral and radial critical buckling loads for the tensile armor wires of flexible pipes. A simple finite element model, based on springs and beams elements, was developed in ABAQUS® to deal with this problem in an efficient and reliable manner. A parametric study was conducted concerning the behavior of the critical load when the laying angle, the initial curvature and the total pipe length are varied. The results were consistent with previously published literature data and analytical expressions, proving its applicability to pipe engineering projects. It also has the advantage of approaching the problem three-dimensionally, which allows further modelling modifications, such as including friction effects.
Status and Dietary Intake of Phytoene and Phytofluene in Spanish Adults and the Effect of a Four-Week Dietary Intervention with Lutein-Rich Fruits or Vegetables

Phytoene (PT) and phytofluene (PTF) are colourless carotenoids presents in the human diet and in blood, faeces and tissues and are biologically active. However, there is very little data on these carotenoids. This study aims to assess PT and PTF concentrations in serum from healthy Spanish normolipemic subjects (n = 101, 45–65 years) and the effect of a fruit and vegetable dietary intervention (4 weeks, n = 29) on PT and PTF concentration in serum and faeces and dietary intake. Serum and faecal concentrations were analysed by HPLC and dietary intake by 3 × 24 h recalls. PT showed higher concentrations than PTF in serum, faeces and in the dietary intake. Considering both studies, PT and PTF concentrations in serum were 0.16 ± 0.07 and 0.05 ± 0.04 µmol/L, respectively, in faeces 17.7 ± 20.3 and 6.5 ± 7.9 µg/g, respectively, and in dietary intake the median was 2.4 and 0.6 mg/p/day, respectively. Carrots and tomatoes were the major dietary contributors of these carotenoids. The dietary intervention did not cause significant variations in the PT and PTF intake or serum concentrations, but a lower concentration in faeces was observed for the fruit group (PT: p = 0.024; PTF isomer-3: p = 0.034). These data highlight the need for further research on the activities of these carotenoids in humans.
Effectiveness of Intramammary Antibiotics, Internal Teat Sealants, or Both at Dry-Off in Dairy Cows: Clinical Mastitis and Culling Outcomes

Intramammary antibiotic (AB) and internal teat sealants (TS) infusion at dry-off have been used to prevent intramammary infections (IMI) in dairy cows during the dry period and reduce the risk of mastitis during the dry period and subsequent lactation. A randomized clinal trial was completed on eight California dairy herds to estimate the effects of different dry cow therapies (AB, TS, AB + TS or None) on clinical mastitis and culling. A total of 1273 cows were randomized to one of the four treatment groups over summer and winter seasons. For each enrolled cow, microbiological testing was done on quarter milk samples collected from the first detection of clinical mastitis within the first 150 days in milk (DIM) in the subsequent lactation. Statistical analysis was done using generalized linear mixed models. There were no significant differences in the odds of clinical mastitis or culling between cows treated with AB, TS, or AB + TS compared to the controls. Dry cow therapy with AB and/or TS had no statistically significant effect on clinical mastitis and cow culling during the first 150 DIM.
Professional Identity Scale for Male Nursing Students Using the Rasch Model and Latent Regression on Gender and Background Variables

This study developed a professional identity (PI) scale and compared the scores of male and female nursing students. Few studies have focused on male nursing students to understand their PI vis-à-vis related background variables relative to female ones. We recruited 384 male nursing students in Taiwan to construct the PI scale based on the Rasch model with 12 items and 3 factors, namely cognitive, emotional, and behavioural identity. The PI scale showed a good model fit in confirmatory factor analysis, with factor loadings ranging from 0.56 to 0.73. Cronbach’s alpha coefficients ranged from 0.72 to 0.79 for the three subscales and 0.88 for the entire scale. The results of the multiple latent regression analyses showed that male nursing students had higher PI in the total scale and its three factors than did female ones. Having mothers with medical or nursing-related jobs may help promote the cognitive PI of male nursing students. Experiences of caring for family members can help promote PI among female nursing students but not among male ones. Future research should focus on decreasing loss in behavioural PI for both genders after graduation and on reinforcing the association between behavioural PI and interest in nursing among male nursing students.
Changes in the Work Schedule of Nurses Related to the COVID-19 Pandemic and Its Relationship with Sleep and Turnover Intention

Background: This study aimed to investigate whether different types of changes in the work schedule of nurses working rotating shifts during the COVID-19 pandemic were associated with sleep duration, sleep quality, and turnover intention. Methods: Cross-sectional questionnaire data from 694 nurses participating in the SUrvey of Shift work, Sleep and Health (SUSSH) were collected between the first and the second wave of the COVID-19 pandemic in Norway. A total of 89.9% were female, and mean age was 44.6 years (SD = 8.6 years). Changes in the shift work schedule related to the pandemic comprised reports of more long workdays (>8 h), less days off between work periods, more night shifts, more quick returns (i.e., 11 h or less between two consecutive shifts), more day shifts, and more evening shifts compared to no change in the respective shift characteristics. Change in sleep duration, sleep quality, and turnover intention as well as demographics were also assessed. Logistic regression analyses were performed to investigate whether changes in the specific work schedules were associated with sleep duration, sleep quality, and turnover intention, controlling for sex, age, cohabitation, children living in household, percentage of full time equivalent and other changes in the work schedule. Results: A total of 17% reported experiencing one or more changes in their work schedule during the pandemic. Experiencing any change in the work schedule predicted worse sleep quality (OR = 2.68, p < 0.001), reduced sleep duration (OR = 4.56, p < 0.001), and higher turnover intention (OR = 1.96, p = 0.006) compared to experiencing no change in work schedule. Among the specific changes in work schedules, experiencing an increase in quick returns had the highest odds ratio for worse sleep quality (OR = 10.34, p = 0.007) and higher turnover intention (OR = 8.49, p = 0.014) compared to those who reported no change in quick returns. Nurses experiencing an increase in long workdays were more likely to report higher turnover intention (OR = 4.37, p = 0.003) compared to those experiencing no change in long workdays. Conclusions: Change in work schedule related to the pandemic was associated with worse sleep quality, reduced sleep duration, and higher turnover intention. Increase in quick returns emerged as especially problematic in terms of sleep quality and turnover intention, along with long workdays, which were associated with higher turnover intention.