Miracle-dz/UniFAR-FTUs huggingface dataset:
J1234+3901: an extremely metal-deficient compact star-forming dwarf galaxy at redshift 0.133

We have obtained optical spectroscopy of one of the most metal-poor dwarf star-forming galaxies (SFG) in the local Universe, J1234+3901, with the Large Binocular Telescope (LBT)/Multi-Object Dual Spectrograph (MODS). This blue compact dwarf (BCD) galaxy with a redshift z=0.133 was selected from the Data Release 14 (DR14) of the Sloan Digital Sky Survey (SDSS). Its properties are extreme in many ways. Its oxygen abundance 12 + log O/H = 7.035+/-0.026 is among the lowest ever observed for a SFG. Its absolute magnitude Mg = -17.35 mag makes it the brightest galaxy among the known BCDs with 12 + log O/H < 7.3. With its low metallicity, low stellar mass M* = 10^7.13 Msun and very low mass-to-light ratio M*/Lg ~ 0.01 (in solar units), it deviates strongly from the mass-metallicity and luminosity-metallicity relations defined by the bulk of the SFGs in SDSS DR14. J1234+3901 has a very high specific star-formation rate sSFR ~ 100 Gyr^-1, indicating very active ongoing star-formation. Its spectrum shows a strong HeII 4686 emission line, with a flux ~ 2.4 per cent that of the Hbeta emission line. The most probable source of ionizing radiation for producing such a strong line is fast radiative shocks. J1234+3901 has a ratio O32 = [OIII]5007/[OII]3727 ~ 15, the highest among the lowest-metallicity SFGs, and is thus likely leaking Lyman continuum radiation. It is a good candidate for being a young dwarf galaxy, with a large fraction of its stars formed recently. As such, it is probably one of the best local counterparts of dwarf primeval galaxies responsible for the reionization of the early Universe.
Code red for humanity or time for broad collective action? Exploring the role of positive and negative messaging in (de)motivating climate action

Despite decades of warning from climate scientists, the international community has largely failed at reining in planet-warming greenhouse gas (GHG) emissions. In this context, scientific assessments of climate change—like those periodic reviews provided by the Intergovernmental Panel on Climate Change (IPCC)—are repeatedly faced with the challenge of communicating the rapidly closing window for securing a livable future on Earth. Yet, it remains unclear whether sounding “code red for humanity” fosters climate action or climate paralysis. The ongoing debate among climate change communication scholars about the (in)effectiveness of fear-based messaging sheds light on three intertwined and often overlooked aspects of emotional appeals in communication: the content of the message frame, the emotional arousal it induces, and the values and dispositions of the audiences receiving the message. While previous work has addressed questions related to one or two of these aspects, this study examines the role of positive and negative messaging in (de)motivating climate action, with particular attention to how messages, emotions and audiences interact in the process of communication. Leveraging data drawn from a sample of environmental group supporters in Canada (N = 308), we first identify and describe four unique audiences within supporters of Canada's environmental movement that vary in their levels of engagement and radicalism. We then examine how negative and positive messaging influence emotional arousal and climate action across audience segments. We find that negative messages about climate change (e.g., sounding “code red for humanity”) can be less mobilizing than positive messaging, even when the message is directed toward relatively engaged audiences and followed by the opportunity to take a specific, actionable and effective action. These findings help shed light on the potential limits of fear-based messaging in the context of a global public health pandemic while further highlighting the importance of communicating in ways that inspire people through hopeful and optimistic messages.
Wear patterns in knee OA correlate with native limb geometry

Background: To date, the amount of cartilage loss is graded by means of discrete scoring systems on artificially divided regions of interest (ROI). However, optimal statistical comparison between and within populations requires anatomically standardized cartilage thickness assessment. Providing anatomical standardization relying on non-rigid registration, we aim to compare morphotypes of a healthy control cohort and virtual reconstructed twins of end-stage knee OA subjects to assess the shape-related knee OA risk and to evaluate possible correlations between phenotype and location of cartilage loss. Methods: Out of an anonymized dataset provided by the Medacta company (Medacta International SA, Castel S. Pietro, CH), 798 end-stage knee OA cases were extracted. Cartilage wear patterns were observed by computing joint space width. The three-dimensional joint space width data was translated into a two-dimensional pixel image, which served as the input for a principal polynomial autoencoder developed for non-linear encoding of wear patterns. Virtual healthy twin reconstruction enabled the investigation of the morphology-related risk for OA requiring joint arthroplasty. Results: The polynomial autoencoder revealed 4 dominant, orthogonal components, accounting for 94% of variance in the latent feature space. This could be interpreted as medial (54.8%), bicompartmental (25.2%) and lateral (9.1%) wear. Medial wear was subdivided into anteromedial (11.3%) and posteromedial (10.4%) wear. Pre-diseased limb geometry had a positive predictive value of 0.80 in the prediction of OA incidence (r 0.58, p < 0.001). Conclusion: An innovative methodological workflow is presented to correlate cartilage wear patterns with knee joint phenotype and to assess the distinct knee OA risk based on pre-diseased lower limb morphology. Confirming previous research, both alignment and joint geometry are of importance in knee OA disease onset and progression.
Radio emission from the unbound debris of tidal disruption events.

When a star gets too close to a supermassive black hole, it is torn apart by the tidal forces. Roughly half of the stellar mass becomes unbound and flies away at tremendous velocities - around 104 km s-1. In this work, we explore the idea that the shock produced by the interaction of the unbound debris with the ambient medium gives rise to the synchrotron radio emission observed in several tidal disruption event (TDE). We use a moving mesh numerical simulation to study the evolution of the unbound debris and the bow shock around it. We find that as the periapse distance of the star decreases, the outflow becomes faster and wider. A TDE whose periapse distance is a factor of 7 smaller than the tidal radius can account for the radio emission observed in ASASSN-14li. This model also allows us to obtain a more accurate estimate for the gas density around the centre of the host galaxy of ASASSN-14li.
Disrupted metabolic and spontaneous neuronal activity of hippocampus in sepsis associated encephalopathy rats: A study combining magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging

Background The diagnosis of sepsis associated encephalopathy (SAE) remains challenging in clinical settings because of a lack of specific biomarkers. Functional magnetic resonance imaging (fMRI) and proton magnetic resonance spectroscopy (1H-MRS) can be used to aid in the diagnosis of cognition related diseases. This study investigated changes in functional activities and brain metabolites in the hippocampus in SAE rats by fMRI and 1H-MRS. Materials and methods Sepsis associated encephalopathy rats underwent cecal ligation and perforation (CLP) surgery. The Morris water maze (MWM) test was then used to evaluate cognitive function. Resting state-fMRI and 1H-MRS scanning were performed 7 and 14 days after CLP surgery to reveal spontaneous neuronal activity and metabolite changes in the hippocampus. The amplitude of low-frequency fluctuation (ALFF) was used to evaluate spontaneous neuronal activity in the hippocampus. Creatine (Cr), Myo-inositol (mI), and glutamine/glutamate (Glx) levels were measured with 1H-MRS scanning. Immunofluorescence and levels of interleukin (IL)-1β, interleukin (IL)-6, and C-reactive protein (CRP) in the hippocampus were additionally detected to evaluate microglial mediated inflammatory responses. Statistical analysis was performed to evaluate correlations between hippocampal metabolism and behavioral findings. Results Cecal ligation and perforation treated rats exhibited impaired learning and memory function in the MWM test at days 7 and 14. Elevation of IL-1β in the hippocampus, as well as immunofluorescence results, confirmed severe neuro inflammation in the hippocampus in SAE rats. Compared with the sham group, the ALFF of the right CA-1 area of the hippocampus was higher at day 7after CLP surgery. The Glx/Cr and mI/Cr ratios were enhanced at day 7 after CLP surgery and slightly lower at day 14 after CLP surgery. The ALFF value, and Glx/Cr and mI/Cr ratios were negatively correlated with time spent in the target quadrant in the MWM test. Conclusion Spontaneous neuronal activity and metabolites showed significant alterations in SAE rats. The elevated ALFF value, Glx/Cr ratio, and mI/Cr ratio in the hippocampus were positively associated with cognitive deficits. Changes in ALFF and metabolites in hippocampus may serve as potential neuroimaging biomarkers of cognitive disorders in patients with SAE.
Case report: Real-world experience using a personalized cancer-specific circulating tumor DNA assay in different metastatic melanoma scenarios

Circulating-tumor DNA (ctDNA) has emerged as an important biomarker for monitoring disease status in cancer patients. Different ctDNA testing platforms have shown promising results in the early detection of disease, monitoring response to treatment, and prognostication in metastatic melanoma. However, several challenges exist, including the reduced shedding of ctDNA into the bloodstream in the metastatic setting, differences in sensitivity among various ctDNA assays, and the inherent inability to distinguish tumor-specific mutations from other mutations that are not related to the cancer of interest. Using a ctDNA assay that is designed to detect multiple single-nucleotide variants (SNVs) that are specific to the tumor itself may allow for more accurate monitoring of disease status in metastatic melanoma. In this case series, we describe a real-world experience using a personalized, tumor-informed ctDNA assay to monitor the clinical trajectories of four patients with metastatic melanoma. Our report highlights potential benefits and limitations using ctDNA in this setting to inform clinical decision-making. This report provides a proof of concept of the technique using an mPCR-NGS-based ctDNA assay (Signatera TM) in the clinical context and in adjunct with other radiological information. Large cohort prospective trials would be needed to validate the utility and validity of this approach.
Regional culture: The role of the invisible hand in shaping local family firms’ top management team

Research on family businesses has focused on the differences between family and non-family firms regarding the top management team (TMT), while this study further explores the difference within family firms from different regional culture based on the perspective of socio-emotional wealth (SEW) and evolutionary psychology. Using a sample comprised of all 625 family firms listed on the Small & Medium Enterprise Board and Growth Enterprise Board in Shenzhen Stock Exchange, this study finds that in regions of strong clan culture, family members are more willing to be involved in a family business and accept lower economic rewards. Particularly, when financial risk is high, these relationships mentioned above become more significant. Based on the results, this study proves that regional culture can affect the characteristics of top management teams in family firms, explains the heterogeneity of family firms’ decision-making from a culture-based perspective and extends existing research on family business from the level of “family firm vs. non-family firm” to that of “family firms affected by different regional cultures”.
Layered double hydroxides for corrosion-related applications—Main developments from 20 years of research at CICECO

This work describes the main advances carried out in the field of corrosion protection using layered double hydroxides (LDH), both as additive/pigment-based systems in organic coatings and as conversion films/pre-treatments. In the context of the research topic “Celebrating 20 years of CICECO”, the main works reported herein are based on SECOP’s group (CICECO) main advances over the years. More specifically, this review describes structure and properties of LDH, delving into the corrosion field with description of pioneering works, use of LDH as additives to organic coatings, conversion layers, application in reinforced concrete and corrosion detection, and environmental impact of these materials. Moreover, the use of computational tools for the design of LDH materials and understanding of ion-exchange reactions is also presented. The review ends with a critical analysis of the field and future perspectives on the use of LDH for corrosion protection. From the work carried out LDH seem very tenable, versatile, and advantageous for corrosion protection applications, although several obstacles will have to be overcome before their use become commonplace.
Understanding plant–microbe interaction of rice and soybean with two contrasting diazotrophic bacteria through comparative transcriptome analysis

Understanding the beneficial plant–microbe interactions is becoming extremely critical for deploying microbes imparting plant fitness and achieving sustainability in agriculture. Diazotrophic bacteria have the unique ability to survive without external sources of nitrogen and simultaneously promote host plant growth, but the mechanisms of endophytic interaction in cereals and legumes have not been studied extensively. We have studied the early interaction of two diazotrophic bacteria, Gluconacetobacter diazotrophicus (GAB) and Bradyrhizobium japonicum (BRH), in 15-day-old seedlings of rice and soybean up to 120 h after inoculation (hai) under low-nitrogen medium. Root colonization of GAB in rice was higher than that of BRH, and BRH colonization was higher in soybean roots as observed from the scanning electron microscopy at 120 hai. Peroxidase enzyme was significantly higher at 24 hai but thereafter was reduced sharply in soybean and gradually in rice. The roots of rice and soybean inoculated with GAB and BRH harvested from five time points were pooled, and transcriptome analysis was executed along with control. Two pathways, “Plant pathogen interaction” and “MAPK signaling,” were specific to Rice-Gluconacetobacter (RG), whereas the pathways related to nitrogen metabolism and plant hormone signaling were specific to Rice-Bradyrhizobium (RB) in rice. Comparative transcriptome analysis of the root tissues revealed that several plant–diazotroph-specific differentially expressed genes (DEGs) and metabolic pathways of plant–diazotroph-specific transcripts, viz., chitinase, brassinosteroid, auxin, Myeloblastosis (MYB), nodulin, and nitrate transporter (NRT), were common in all plant–diazotroph combinations; three transcripts, viz., nitrate transport accessory protein (NAR), thaumatin, and thionin, were exclusive in rice and another three transcripts, viz., no apical meristem, Petunia (NAC), abscisic acid (ABA), and ammonium transporter, were exclusive in soybean. Differential expression of these transcripts and reduction in pathogenesis-related (PR) protein expression show the early interaction. Based on the interaction, it can be inferred that the compatibility of rice and soybean is more with GAB and BRH, respectively. We propose that rice is unable to identify the diazotroph as a beneficial microorganism or a pathogen from an early response. So, it expressed the hypersensitivity-related transcripts along with PR proteins. The molecular mechanism of diazotrophic associations of GAB and BRH with rice vis-à-vis soybean will shed light on the basic understanding of host responses to beneficial microorganisms.
Relationship between geomagnetic storms and occurrence of ionospheric irregularities in the west sector of Africa during the peak of the 24th solar cycle

The study of ionospheric irregularities is important since many technological systems might be influenced by the ionosphere. In this work, we use data from the Global Navigation Satellite Systems (GNSS) receiver installed in Abuja, Nigeria, GPS Scintillation Network Decision Aid (SCINDA) TEC data from the Air Force Research Laboratory (AFRL) data archive, and the geomagnetic data from the World Data Center (WDC) in Kyoto, Japan, to investigate the relationship between geomagnetic storm and ionospheric irregularity occurrences using the rate of change of total electron content (TEC) index (ROTI), with a validation using the S4 indices, during the peak of the 24th solar cycle. The occurrences of irregularities were investigated on day-to-day and seasonal bases. The nighttime ionospheric irregularities, which are attributed to ionospheric plasma irregularities in the equatorial ionospheric F-region, were found to be prevalent. To investigate the relationship between the strength of ionospheric irregularities (ROTI) and the geomagnetic storm (Dst), the periodogram power spectral density (PSD) and regression analysis were used. The results showed that there was no correlation, cc = 0.073, between the Dst and ROTI, implying that the strengths of ionospheric irregularities occurring during geomagnetic storms are not strictly decided by the magnitudes of the storms; this was also confirmed using the S4 index. The impact of geomagnetic storms caused enhanced development or inhibition of ionospheric irregularities. We observed that the bulk of the storms occurring during the period of this study is not associated with ionospheric irregularities. Finally, the investigation showed that the correlation between the ROTI and Dst observed during the coronal mass ejection (CME)-driven geomagnetic storms was higher than that during the corotating interaction region (CIR)-driven geomagnetic storms, during the peak of the 24th solar cycle. The results of this work confirm the findings by other researchers.
Quantum dynamics and thermalization for out-of-equilibrium phi^4-theory

The quantum time evolution of ${\ensuremath{\varphi}}^{4}$-field theory for a spatially homogeneous system in 2+1 space-time dimensions is investigated numerically for out-of-equilibrium initial conditions on the basis of the Kadanoff-Baym equations including the tadpole and sunset self-energies. Whereas the tadpole self-energy yields a dynamical mass, the sunset self-energy is responsible for dissipation and an equilibration of the system. In particular we address the dynamics of the spectral (``off-shell'') distributions of the excited quantum modes and the different phases in the approach to equilibrium described by Kubo-Martin-Schwinger relations for thermal equilibrium states. The investigation explicitly demonstrates that the only translation invariant solutions representing the stationary fixed points of the coupled equation of motions are those of full thermal equilibrium. They agree with those extracted from the time integration of the Kadanoff-Baym equations for $\stackrel{\ensuremath{\rightarrow}}{t}\ensuremath{\infty}. $ Furthermore, a detailed comparison of the full quantum dynamics to more approximate and simple schemes such as that of a standard kinetic (on-shell) Boltzmann equation is performed. Our analysis shows that the consistent inclusion of the dynamical spectral function has a significant impact on relaxation phenomena. The different time scales that are involved in the dynamical quantum evolution towards a complete thermalized state are discussed in detail. We find that far off-shell $1\ensuremath{\leftrightarrow}3$ processes are responsible for chemical equilibration, which is missed in the Boltzmann limit. Finally, we briefly address the case of (bare) massless fields. For sufficiently large couplings $\ensuremath{\lambda}$ we observe the onset of Bose condensation, where our scheme within symmetric ${\ensuremath{\varphi}}^{4}$ theory breaks down.
Clostridium butyricum potentially improves inflammation and immunity through alteration of the microbiota and metabolism of gastric cancer patients after gastrectomy

Background Gastrectomy is the most effective treatment to improve the clinical survival rate of patients with gastric cancer. However, the pathophysiological changes caused by gastrectomy have seriously affected the postoperative recovery. Methods In the present trial, Ataining (containing C. butyricum, CGMCC0313.1) was applied in patients after gastrectomy to investigate the effect of C. butyricum on the early postoperative recovery by monitoring the inflammatory immune response with blood indicators, detecting the gut microbiota with high-throughput sequencing, and analyzing the short-chain fatty acids (SCFAs) with targeted metabolomics. This study is registered with the number ChiCTR2000040915. Results Our outcomes revealed that C. butyricum had significantly reduced the number of Leucocyte (P < 0.001), the percentage of Neutrophil (P < 0.001), the expression of IL-1β (P < 0.01), IL-6 (P < 0.05), and TNF-α (P < 0.01), while markedly enhanced the immunity indexes (immunoglobulin and lymphocyte) (P < 0.05) and nutrition indexes (albumin and total protein) (P < 0.05). In addition, the use of the C. butyricum greatly enriched the relative abundance of beneficial bacteria Bacteroides, Faecalibacterium and Gemmiger, while the abundance of pathogenic Streptococcus, Desulfovibrio and Actinomyces were markedly decreased at genus level. We also observed significant up-regulation of SCFAs, including acetic acid, propionic acid, butyric acid and isobutyric acid, after C. butyricum administration in patients receiving gastrectomy. Conclusion Therefore, evidence supported that oral administration of C. butyricum after gastrectomy can reduce early postoperative inflammation, enhance immune ability, restore intestinal microbiota eubiosis, increase intestinal SCFAs, reduce the occurrence of postoperative complications, and ultimately promote the early recovery of the patient. Clinical trial registration http://www.chictr. org.cn/, identifier (ChiCTR2000040915).