Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute-Phase Inflammatory Reaction Predicts CMR Myocardial Scar Pattern and 2-Year Mortality in STEMI Patients Undergoing Primary PCI

(1) Background: The inflammatory response following MI plays an important role in the healing, scar formation, and left ventricle (LV) remodeling. Cardiac magnetic resonance (CMR) imaging can accurately quantify the extent of myocardial scarring. The study aimed to investigate: (a) the relationship between acute inflammatory response and the CMR parameters of the scarring extent, and (b) the predictive power of inflammatory biomarkers and myocardial scarring for 2-year mortality. (2) Methods: The study included 202 STEMI patients, who underwent pPCI. Serum hs-CRP, IL-6, P-selectin, E-selectin, I-CAM, and V-CAM levels were determined at admission, and hs-CRP on the fifth day. Patients underwent LGE-CMR after 1 month, for LV volumes, ejection fraction (EF), infarct size (IS), and transmurality. Subjects were divided into tertiles according to the IS, and 2-year all-cause mortality was determined. (3) Results: IL-6 was associated with IS (r = 0.324, p = 0.01), increased transmurality index (r = 0.3, p = 0.01), and lower LVEF (r = −0.3, p = 0.02). Admission hs-CRP levels were not associated with IS, transmurality, or mortality, while hs-CRP at day 5 was a significant predictor for IS (AUC = 0.635, p = 0.05) as well as IL-6 levels (AUC = 0.685, p < 0.001). Mortality was significantly higher in the upper IS tertiles (6% vs. 8.7% vs. 24.52%, p = 0.005). IS was a significant predictor of 2-year mortality (AUC = 0.673, p = 0.002), with a cut-off value of 28.81 g, as well as high transmurality (AUC = 0.641, p = 0.013), with a cut off value of 18.38 g. (4) Conclusions: The serum levels of IL-6 and day-5 hs-CRP predict IS and transmurality, and day-5 hs-CRP levels are independent predictors of 2-year mortality in STEMI patients treated with pPCI. The CMR pattern of myocardial scarring after 1 month, as expressed by the magnitude of IS and transmurality, is a significant predictor for 2-year mortality after revascularized STEMI.
Calibrated Equivalent Viscous Damping for Direct Displacement Based Seismic Design of Pallet-Type Steel Storage Racks

ABSTRACT Direct displacement-based seismic design has been proposed for pallet-type steel storage racks. Damping models are developed in this study for pallet-type steel storage racks in the down-aisle and cross-aisle directions for use in direct displacement-based seismic design. The damping models are developed using results from reversed cyclic tests at a component level or at a system level. Jacobsen’s approach is used to develop a first set of damping models. The damping models are then assessed using results from nonlinear time-history analyses. Finally, the damping models are calibrated using an iterative procedure based on results from nonlinear time-history analyses.
Anti-inflammatory and Antioxidant Activity of White Pepper Oleoresin Mediated Selenium Nanoparticles

Introduction: Indian spices such as turmeric, ginger, and mint bring color and flavor to food and cure many ailments too. Aim: To study the anti-inflammatory and antioxidant activity of white pepper oleoresin-mediated selenium nanoparticles. Materials and Methods: The white pepper oleoresin extract was collected from Synthite Industries Pvt Limited, with a product code - 4010000835. Selenium nanoparticles were initially prepared using white pepper oleoresin and DPPH assay was performed on the different concentrations of white pepper oleoresin (10, 20, 30, 40, 50 μg/ml) for antioxidant activity, and anti-inflammatory activity was tested by the following method proposed by Muzushima and Kabayashi with specific alterations. Results: White pepper has shown a very good anti-inflammatory effect and antioxidant activity when compared to the standard used at higher concentrations. Selenium nanoparticles appeared to have 90 percent inhibition in 50μL, which was also higher than the standard. Selenium nanoparticles seemed to have 85 percent inhibition in 50μL, which was also lower than the standard. Conclusion: The present study has demonstrated an eco-friendly and cost-effective synthesis of Selenium nanoparticles using White pepper oleoresin. White pepper oleoresin mediated Selenium nanoparticles were with good anti-inflammatory and antioxidant activity which may be utilized include for its use in inflammatory and other conditions where there is a requirement for antioxidant activity.
Drug-Biopolymer Dispersions: Morphology- and Temperature- Dependent (Anti)Plasticizer Effect of the Drug and Component-Specific Johari–Goldstein Relaxations

Amorphous molecule-macromolecule mixtures are ubiquitous in polymer technology and are one of the most studied routes for the development of amorphous drug formulations. For these applications it is crucial to understand how the preparation method affects the properties of the mixtures. Here, we employ differential scanning calorimetry and broadband dielectric spectroscopy to investigate dispersions of a small-molecule drug (the Nordazepam anxiolytic) in biodegradable polylactide, both in the form of solvent-cast films and electrospun microfibres. We show that the dispersion of the same small-molecule compound can have opposite (plasticizing or antiplasticizing) effects on the segmental mobility of a biopolymer depending on preparation method, temperature, and polymer enantiomerism. We compare two different chiral forms of the polymer, namely, the enantiomeric pure, semicrystalline L-polymer (PLLA), and a random, fully amorphous copolymer containing both L and D monomers (PDLLA), both of which have lower glass transition temperature (Tg) than the drug. While the drug has a weak antiplasticizing effect on the films, consistent with its higher Tg, we find that it actually acts as a plasticizer for the PLLA microfibres, reducing their Tg by as much as 14 K at 30%-weight drug loading, namely, to a value that is lower than the Tg of fully amorphous films. The structural relaxation time of the samples similarly depends on chemical composition and morphology. Most mixtures displayed a single structural relaxation, as expected for homogeneous samples. In the PLLA microfibres, the presence of crystalline domains increases the structural relaxation time of the amorphous fraction, while the presence of the drug lowers the structural relaxation time of the (partially stretched) chains in the microfibres, increasing chain mobility well above that of the fully amorphous polymer matrix. Even fully amorphous homogeneous mixtures exhibit two distinct Johari–Goldstein relaxation processes, one for each chemical component. Our findings have important implications for the interpretation of the Johari–Goldstein process as well as for the physical stability and mechanical properties of microfibres with small-molecule additives.
Safety and Efficacy of Ipilimumab plus Nivolumab and Sequential Selective Internal Radiation Therapy in Hepatic and Extrahepatic Metastatic Uveal Melanoma

Simple Summary Despite recent progress on the treatment of metastatic uveal melanoma (mUM), prognosis remains dismal for the majority of patients. Directed liver therapies including selective internal radiation therapy (SIRT) have been the pillar of hepatic metastases management. Independently, immune checkpoint blockade by combination of ipilimumab plus nivolumab has demonstrated a median survival slightly superior to 1 year. However, the benefit of sequential ipilimumab plus nivolumab immunotherapy and SIRT has not been elucidated. Abstract To assess the safety and efficacy of ipilimumab plus nivolumab around selective internal radiation therapy (SIRT) in patients with metastatic uveal melanoma (mUM). We present a retrospective, single center study of 32 patients with mUM divided into two groups based on the treatment received between April 2013 and April 2021. The SIRT_IpiNivo cohort was treated with Yttrium-90 microspheres and ipilimumab plus nivolumab before or after the SIRT (n = 18). The SIRT cohort underwent SIRT but did not receive combined immunotherapy with ipilimumab plus nivolumab (n = 14). Twelve patients (66.7%) of the SIRT_IpiNivo arm received SIRT as first-line treatment and six patients (33.3%) received ipilimumab plus nivolumab prior to SIRT. In the SIRT group, seven patients (50.0%) received single-agent immunotherapy. One patient treated with combined immunotherapy 68 months after the SIRT was included in this group. At the start of ipilimumab plus nivolumab, 94.4% (n = 17) presented hepatic metastases and 72.2% (n = 13) had extra liver disease. Eight patients (44.4%) of the SIRT_IpiNivo group experienced grade 3 or 4 immune related adverse events, mainly colitis and hepatitis. Median overall survival from the diagnosis of metastases was 49.6 months (95% confidence interval (CI); 24.1-not available (NA)) in the SIRT_IpiNivo group compared with 13.6 months (95% CI; 11.5-NA) in the SIRT group (log-rank p-value 0.027). The presence of extra liver metastases at the time of SIRT, largest liver lesion more than 8 cm (M1c) and liver tumor volume negatively impacted the survival. This real-world cohort suggests that a sequential treatment of ipilimumab plus nivolumab and SIRT is a well-tolerated therapeutic approach with promising survival rates.
Political Influencers on YouTube: Business Strategies and Content Characteristics

Young media users increasingly engage with public affairs via social media such as YouTube, where content is increasingly produced by influencers who neither represent established professional news media nor political parties. Although the audience of these channels is already substantial in absolute terms and still growing enormously—making alternative influencers serious competitors to professional journalism—we still know little about their ways of attracting and monetizing audiences, the topics they emphasize, or the specific content they provide. To address this void, the present study examines political videos and their producers on YouTube in an explorative and comparative way for English- and German-speaking YouTube channels. We conducted a content analysis of the five most popular YouTube videos for each of the 20 most successful English- and German-speaking political influencers in 2020. Our analyses show that, although English YouTubers already appear to be more professionalized, similar patterns emerge in both language regions, particularly with regards to increasing efforts to manage microcelebrity status. In terms of content, two main types of political YouTube videos were identified: “partisan mockery” and “engaging education. ” Results will be discussed in terms of their implications for political discourse, youth participation, and established journalistic media.
Stator Current Spectral Content of Inverter-Fed Cage Rotor Induction Motor

The paper analyzes the influence of the number of rotor bars on the stator current spectral content in a three-phase cage induction motor fed by a pulse-width modulated (PWM) inverter. It is shown that each of the higher-order time harmonics in the supply voltage produces space harmonics in a rotating magnetic flux density wave, which results in induced rotor slot harmonics (RSHs) in the stator current spectrum. The conditions for the existence of these space harmonics are identical to those applying to a mains-fed motor. In other words, the number of rotor bars of a mains-fed motor yielding an RSH-free stator current spectrum produces the same stator current spectrum even in case the motor is inverter-fed. Additionally, to minimize the adverse effects of RSHs in the stator current spectrum, one must consider not only the number of rotor bars, but also its relationship with the frequency modulation ratio of the PWM inverter. Analytical predictions are presented to illustrate these results supported both by numerical simulations of the induction motor modelled through the winding function theory and experimentally taking the case a two-pole cage induction machine as a case study.
Codebook Designs for Millimeter-Wave Communication Systems in Both Low- and High-Mobility: Achievements and Challenges

More connectivity, higher data rates, more reliability, massive network capacity, higher performance and fewer delays are required in the fifth generation (5G) of cellular networks. The last ten years have contained explosive growth in mobile data traffic due to the rapid proliferation of Internet-connected smart devices. For 5G mobile and wireless networks, one of the challenges is to discover how to solve the dilemma between capacity requirements and spectrum shortage. Millimeter-wave communication is therefore a key enabler for 5G technologies. Due to the high path and penetration losses at millimeter wavelengths, antenna beamforming assumes a pivotal role in establishing and maintaining a robust communication link. Recently, codebook-based beamforming has been proposed to achieve a fair balance between complexity and performance and to eliminate the overheads. In this paper, we track the techniques of codebook-based beamforming for millimeter-wave communications in the context of the distinct requirements for low-mobility channel and high-mobility channel scenarios. Subsequently, we will provide a comparison of existing codebook-based beamforming techniques in terms of their respective benefits and shortcomings. Finally, some open directions of research are discussed, and challenges that need to be met are pointed out.
The Port Throughput Forecast Model Based on the BP Neural Network

Port throughput forecasting is the premise of port decision-making and planning.In order to forecast the port throughput reasonably,this paper takes foreign trade volume,the first industrial output and the third industry output as input variables and port throughput as output variables of the BP neural network to build the its forecast model of the port throughput.Then,according to the 2000-2010’s date of the North Gulf in Guangxi,the author uses Matlab 6.5 software neural network toolbox to train the BP neural network model repeat,and finds that the forecast effect is best when hidden node number is 6,adopted is 0.05,train time is 500,train accuracy is 0.001 and momentum factors is 0.9. By comparing the results with that from multivariate linear regression prediction model,the paper concludes that the BP neural network model is more superior.Finally,the author uses the determined BP neural network model to forecast the 2011 and 2012 two years of port throughput in the future.
Assessing the Environmental and Economic Sustainability of Functional Food Ingredient Production Process

Development and application of novel technologies in food processing is vital for ensuring the availability of adequate, safe, and convenient food with the desired quality and functional properties. Environmental and economic sustainability of technologies is essential prior to their application in the food processing sector. The objective of this research is to determine the environmental and economic feasibility of ultrasound-assisted extraction (UAE) for recovering functional food ingredients from seaweed. Experimental data is used to conduct a life cycle assessment (LCA) to investigate the environmental performance with a functional unit (FU) of obtaining 1 g of extracted polyphenols, measured as gallic acid equivalents (mg GAE)/g seaweed. A life cycle impact assessment is performed with ReCiPe 2016 at midpoint. The cost of manufacturing (COM) of phenolic-rich extracts (as functional ingredient, bioactive, or nutraceutical) is estimated using time-driven activity-based costing (TDABC). The environmental profile findings show that across all categories, the UAE has considerably lower impacts than the conventional method, with electricity as the most important impact contributor, followed by solvent production. An economic assessment estimates the COM over a one-year period at a large scale using the UAE to be EUR 1,200,304, EUR 2,368,440, and EUR 4,623,290 for extraction vessel capacities of 0.05, 0.1, and 0.15 m3, respectively. Raw materials (including the type of raw material) and operational labour costs are the primary contributors to the COM. The findings thus present evidence to support the adoption of an environmentally and economically viable technology for functional ingredient production.
The contribution of the traditional game of congklak to mathematics learning: How is the relationship and influence of interest, cooperative character and student responses

This study tested a sample of 70 students with variables of interest, cooperation skills and responses in the math game of congklak from two schools, namely SD IT Aulia and SDN 112/I Perumnas. The objectives of the study: (1) to determine the comparison between interest, cooperative character and student responses in the traditional game of congklak in mathematics. (2) to determine the relationship of interest, cooperation with students' responses to the traditional game of congklak in mathematics. This type of research uses quantitative methods with a comparative type. The instrument in this study used a questionnaire on interests and observation sheets, namely the character of cooperation and student responses to the traditional game of congklak in mathematics. The results of the T-test obtained based on the table can be found that there is a relationship between interest, cooperative character and student responses in the traditional game of Congklak. In the table-based test, it can be said that there is a relationship between interest, cooperative character and student responses to the traditional game of congklak in mathematics
Online Travel Agencies and Their Role in the Tourism Industry

This article aims to present the evolution of online travel agencies, the main themes, authors, and methodologies, through a systematized review. The analysis has focused on 61 papers published from 2009 until 2020. The research was limited by the journal ranking in the subject category tourism, leisure and hospitality management in the Scimago Journal and Country Rank. Field research is the most frequent in studies in the area. However, the interest in experiments and content analysis grows, using the content generated by customers in the online travel agencies. This study helps to collaborate in the authors’ decisionmaking regarding the methodology to be used and which authors are being negotiated in future research. The results showed how the theme has evolved, changes in approaches, the way online travel agencies report to their partners (often in a conflictual way) and customers, pointing out new trends to be studied. There was no literature review about online travel agencies published in the journals used for this research, to the best of our knowledge. Cover many years and expand the search to other academic journals is our suggestion for future research. 1 Address correspondence to Gisele Magrini GARCIA, 5th Avenue, 1,100 Block 07 Room 204, Neighborhood: Municipalities, CEP 88337-300 Balneário Camboriú, SC Brazil. E-mail: gimagrinigarcia@gmail.com
Processing of Functional Yoghurt-Like Product from Soymilk Supplemented by Probiotics

In this study, a new functional yoghurt-like product was manufactured using soymilk (sample B), mix of soymilk and cow milk (sample C), and both were compared with yoghurt of cow milk (sample A) as a control. The three yoghurt samples (A, B, and C) were processed using the traditional starter culture and Bifidobacterium bifidum: (A) 100% cow milk yoghurt, (B) 100% soymilk yoghurt, and (C) (50%cow milk + 50%soy milk) yoghurt. All samples were stored at 4°C for 15 days and analyzed on 1st, 7th, and 15th day of the storage period. The results showed that all samples have kept a vital force of 106 colony/g until the 15th day of cooled storage period, and thus, achieving the feature of probiotic food. Moreover, soymilk yoghurt had the highest content of protein (3.75%) and the highest levels of unsaturated fatty acids, making it nutritious and healthy food. Furthermore, it had an acceptable taste, smell, and a firm texture. This product may be considered as a probiotic vegan and partial alternative to cow milk yoghurt. Additionally, adding probiotic bacteria prolonged the shelf-life and improved the flavor of soymilk.
Altered p16Ink4a, IL-1β, and Lamin b1 Protein Expression Suggest Cellular Senescence in Deep Endometriotic Lesions

Endometriosis causes immunological and cellular alterations. Endometriosis lesions have lower levels of lamin b1 than the endometrium. Moreover, high levels of pro-inflammatory markers are observed in the peritoneal fluid, follicular fluid, and serum in endometriosis lesions. Thus, we hypothesized that the accumulation of senescent cells in endometriosis tissues would facilitate endometriosis maintenance in an inflammatory microenvironment. To study senescent cell markers and the senescence-associated secretory phenotype (SASP) in endometriosis lesions, we conducted a cross-sectional study with 27 patients undergoing video laparoscopy for endometriosis resection and 19 patients without endometriosis. Endometriosis lesions were collected from patients with endometriosis, while eutopic endometrium was collected from patients both with and without endometriosis. Tissues were evaluated for senescence markers (p16Ink4a, lamin b1, and IL-1β) and interleukin concentrations. The expression of p16Ink4a increased in lesions compared to that in eutopic endometrium from endometriosis patients in the secretory phase. In the proliferative phase, lesions exhibited lower lamin b1 expression but higher IL-4 expression than the eutopic endometrium. Further, IL-1β levels were higher in the lesions than in the eutopic endometrium in both the secretory and proliferative phases. We believe that our findings may provide targets for better therapeutic interventions to alleviate the symptoms of endometriosis.
The Bilateral Interplay between Cancer Immunotherapies and Neutrophils’ Phenotypes and Sub-Populations

Immunotherapy has become a leading modality for the treatment of cancer, but despite its increasing success, a substantial number of patients do not benefit from it. Cancer-related neutrophils have become, in recent years, a subject of growing interest. Distinct sub-populations of neutrophils have been identified at advanced stages of cancer. In this study, we aimed to evaluate the role of neutrophils in mediating the efficacy of immune checkpoint inhibitors (ICI) treatments (α-PD-1/PD-L1), by assessing lung tumor models in mice. We found that G-CSF overexpression by the tumor significantly potentiates the efficacy of ICI, whereas neutrophils’ depletion abrogated their responses. Adoptive transfer of circulating normal-density neutrophils (NDN) resulted in significantly reduced tumor growth, whereas low-density neutrophils (LDN) had no effect. We next investigated the effect of ICI on neutrophils’ functions. Following α-PD-L1 treatment, NDN displayed increased ROS production and increased cytotoxicity toward tumor cells but decreased degranulation. Together, our results suggest that neutrophils are important mediators of the ICI treatments and that mainly NDN are modulated following α-PD-L1 treatment. This research provides a better understanding of the function of neutrophils following immunotherapies and their impact on the efficacy of immunotherapy, supporting better understanding and future improvement of currently available treatments.