Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential Role of Factor XIII in Acute Myocardial Infarction and Ischemic Stroke

Factor XIII is a transglutaminase enzyme that plays a crucial role in hemostasis and wound healing. It crosslinks fibrin strands, stabilizing clots and promoting clot resistance to fibrinolysis. Additionally, Factor XIII has been found to have multiple other functions that extend beyond coagulation, including the regulation of inflammation and tissue repair processes. Emerging evidence suggests that Factor XIII may also have differential roles in acute myocardial infarction and ischemic stroke, two common cardiovascular events with significant morbidity and mortality. In acute myocardial infarction, Factor XIII has been implicated in promoting clot stability and reducing the risk of re-occlusion. In ischemic stroke, Factor XIII may also contribute to the pathogenesis of cerebral ischemia by promoting clot formation and exacerbating neuronal damage. Several studies have investigated the association between Factor XIII and these cardiovascular events, using various approaches such as genetic polymorphism analysis, animal models, and clinical data analysis. These studies have provided important insights into the role of Factor XIII in acute myocardial infarction and ischemic stroke, highlighting its potential as a therapeutic target for interventions aimed at improving outcomes in these conditions. In this review, we will summarize the current understanding of Factor XIII’s role in acute myocardial infarction and ischemic stroke.
Physiological effects of dual target DBS in an individual with Parkinson's Disease and a sensing-enabled pulse generator

Introduction Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus (GP) is an established therapy for Parkinson's disease (PD). Novel DBS devices can record local field potential (LFP) physiomarkers from the STN or GP. While beta (13-30 Hz) and gamma (40-90 Hz) STN and GP LFP oscillations correlate with PD motor severity and with therapeutic effects of treatments, STN-GP interactions in electrophysiology in patients with PD are not well characterized. Methods Simultaneous bilateral STN and GP LFPs were recorded in a patient with PD who received bilateral STN-DBS and GP-DBS. Power spectra in each target and STN-GP coherence were assessed in various ON- and OFF-levodopa and DBS states, both at rest and with voluntary movement. Results OFF-levodopa and OFF-DBS, beta peaks were present at bilateral STN and GP, coincident with prominent STN-GP beta coherence. Levodopa and dual-target-DBS (simultaneous STN-DBS and GP-DBS) completely suppressed STN-GP coherence. Finely-tuned gamma (FTG) activity at half the stimulation frequency (62.5Hz) was seen in the STN during GP-DBS at rest. To assess the effects of movement on FTG activity, we recorded LFPs during instructed movement. We observed FTG activity in bilateral GP and bilateral STN during contralateral body movements while on GP-DBS and ON-levodopa. No FTG was seen with STN-DBS or dual-target-DBS. Conclusion Dual-target-DBS and levodopa suppressed STN-GP coherence. FTG throughout the basal ganglia was induced by GP-DBS in the presence of levodopa and movement. This bilateral STN-FTG and GP-FTG corresponded with the least severe bradykinesia state, suggesting a pro-kinetic role for FTG.
Temporal Profile of the Microbial Community and Volatile Compounds in the Third-Round Fermentation of Sauce-Flavor baijiu in the Beijing Region

Sauce-flavor baijiu produced in the Beijing and Guizhou regions has regional characteristic flavors, but the differences in flavor compounds and reasons for their formation remain unclear. The sauce-flavor baijiu brewing process involves several rounds of fermentation. In this study, we investigated the temporal distribution of microbial communities and flavor substances during the third round of sauce-flavor baijiu fermentation in the Beijing region, and we then compared and analyzed the differences of flavor substances and microorganisms in the fermented grains of sauce-flavor baijiu in the Beijing and Guizhou regions. It was found that 10 bacterial genera and 10 fungal genera were dominant in the fermented grains. The acidity of the fermented grains had a significant driving effect on the microbial community succession. A total of 81 volatile compounds were identified and quantified in the fermented grains, of which esters and alcohols were relatively abundant. The differences in 30 microbial community compositions and their resulting differences in terms of the fermentation parameters of fermented grains are responsible for the differences in the profiles of flavor compounds between sauce-flavor baijiu produced in the Beijing and Guizhou regions.
Validation of high‐resolution MAIAC aerosol product over South America

Multiangle Implementation of Atmospheric Correction (MAIAC) is a new Moderate Resolution Imaging Spectroradiometer (MODIS) algorithm that combines time series approach and image processing to derive surface reflectance and atmosphere products, such as aerosol optical depth (AOD) and columnar water vapor (CWV). The quality assessment of MAIAC AOD at 1 km resolution is still lacking across South America. In the present study, critical assessment of MAIAC AOD550 was performed using ground‐truth data from 19 Aerosol Robotic Network (AERONET) sites over South America. Additionally, we validated the MAIAC CWV retrievals using the same AERONET sites. In general, MAIAC AOD Terra/Aqua retrievals show high agreement with ground‐based measurements, with a correlation coefficient (R) close to unity (RTerra:0.956 and RAqua: 0.949). MAIAC accuracy depends on the surface properties and comparisons revealed high confidence retrievals over cropland, forest, savanna, and grassland covers, where more than 2/3 (~66%) of retrievals are within the expected error (EE = ±(0.05 + 0.05 × AOD)) and R exceeding 0.86. However, AOD retrievals over bright surfaces show lower correlation than those over vegetated areas. Both MAIAC Terra and Aqua retrievals are similarly comparable to AERONET AOD over the MODIS lifetime (small bias offset ~0.006). Additionally, MAIAC CWV presents quantitative information with R ~ 0.97 and more than 70% of retrievals within error (±15%). Nonetheless, the time series validation shows an upward bias trend in CWV Terra retrievals and systematic negative bias for CWV Aqua. These results contribute to a comprehensive evaluation of MAIAC AOD retrievals as a new atmospheric product for future aerosol studies over South America.
Reflection On Service-Learning Among Universiti Teknologi Malaysia Students

The purpose of service learning is to connect theory and practice in a way that gives students a prospect to both take part in a service activity that meets community needs, as well as reflect on the experience in class to enhance their civic engagement and deepen their understanding of course content. A successful service-learning program requires reflective practice. The School of Education at Universiti Teknologi Malaysia (UTM), Malaysia has been conducting service-learning for many years. Although there is no proper guideline for the students to reflect on their service-learning experiences, students are still expected to do so. The objective in this study are describing service-learning experience. This research study applies case study research method among students’ reflective experiences in service-learning at School of Education in UTM. Data collection was done using qualitative research methodology involving semi structured interviews with UTM postgraduates. Triangulation method used to validate the data and continued with thematic analysis to identify the themes. The findings for every research question have been plotted in diagram. Based on the themes from the findings, a template was proposed for improving service-learning reflection for the students from UTM.
Global interactions: migration systems processes and policies.

The authors use examples from the other 17 chapters in this book to help describe the key elements of a systems approach to the study of international migration. They conclude that "in an increasingly interconnected world few countries can be simply categorized as receivers or senders of migrants and only the adoption of a wide perspective with regard to migration can advance our understanding about the coexistence of inflows and outflows of migrants from the same country or of the simultaneous admission of highly skilled workers and low-skilled ones by another. " The geographical scope is worldwide. (EXCERPT)
Measuring stakeholders' attitudes toward sustainable development of conference and congress tourism: Serbia case study

Purpose - Scientific publications regarding business tourism, especially those which incorporate elements of sustainable development, still remain scarce in the existing literature. Therefore, the aim of this paper is to examine attitudes of local tourist organizations, travel agencies, catering establishments, chambers of commerce and other relevant stakeholders towards the sustainable development of conference and Congress tourism (CCT) in Vojvodina, Serbia. Methodology-In order to investigate the attitudes of stakeholders (n=174), the adapted sustainable tourism attitude scale (SUS-TAS) was used in this paper. Moreover, the responses of the directors (managers) of local tourism organizations to several open-ended questions, which make an integral part of the survey, are also presented. Findings-The research instrument proved to be reliable. Based on other applied analyses (t-test and ANOVA), the existence of numerous statistically significant differences in the responses in relation to gender, job position, sector of work, age and education were identified. Implications-Apart from theoretical contribution, this paper reveals what aspects of CCT are in stakeholders' main focus and what seems to be out of their radar. This should help defining necessary actions for further improvements of CCT. Lastly, study limitations and future research guidelines are discussed.
A Staged Real-Time Ground Segmentation Algorithm of 3D LiDAR Point Cloud

Ground segmentation is a crucial task in the field of 3D LiDAR perception for autonomous driving. It is commonly used as a preprocessing step for tasks such as object detection and road extraction. However, the existing ground segmentation algorithms often struggle to meet the requirements of robustness and real-time performance due to significant variations in ground slopes and flatness across different scenes, as well as the influence of objects such as grass, flowerbeds, and trees in the environment. To address these challenges, this paper proposes a staged real-time ground segmentation algorithm. The proposed algorithm not only achieves high real-time performance but also exhibits improved robustness. Based on a concentric zone model, the algorithm filters out reflected noise points and vertical non-ground points in the first stage, improving the validity of the fitted ground plane. In the second stage, the algorithm effectively addresses the issue of undersegmentation of ground points through three steps: ground plane fitting, ground plane validity judgment, and ground plane repair. The experimental results on the SemanticKITTI dataset demonstrate that the proposed algorithm outperforms the existing methods in terms of segmentation results.
Genetic Variants Associated With Response to Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer Patients: A Field Synopsis and Meta‐Analysis

Background: Publications on the associations of genetic variants with the response to platinum-based chemotherapy (PBC) in NSCLC patients have surged over the years, but the results have been inconsistent. Here, a comprehensive meta-analysis was conducted to combine eligible studies for a more accurate assessment of the pharmacogenetics of PBC in NSCLC patients. Methods: Relevant publications were searched in PubMed, Scopus, and Web of Science databases through 15 May 2021. Inclusion criteria for eligible publications include studies that reported genotype and allele frequencies of NSCLC patients treated with PBC, delineated by their treatment response (sensitive vs. resistant). Publications on cell lines or animal models, duplicate reports, and non-primary research were excluded. Epidemiological credibility of cumulative evidence was assessed using the Newcastle-Ottawa Scale (NOS) and Venice criteria. Begg’s and Egger’s tests were used to assess publication bias. Cochran’s Q-test and I2 test were used to calculate the odds ratio and heterogeneity value to proceed with the random effects or fixed-effects method. Venice criteria were used to assess the strength of evidence, replication methods and protection against bias in the studies. Results: A total of 121 publications comprising 29,478 subjects were included in this study, and meta-analyses were performed on 184 genetic variants. Twelve genetic variants from 10 candidate genes showed significant associations with PBC response in NSCLC patients with strong or moderate cumulative epidemiological evidence (increased risk: ERCC1 rs3212986, ERCC2 rs1799793, ERCC2 rs1052555, and CYP1A1 rs1048943; decreased risk: GSTM1 rs36631, XRCC1 rs1799782 and rs25487, XRCC3 rs861539, XPC rs77907221, ABCC2 rs717620, ABCG2 rs2231142, and CDA rs1048977). Bioinformatics analysis predicted possible damaging or deleterious effects for XRCC1 rs1799782 and possible low or medium functional impact for CYP1A1 rs1048943. Conclusion: Our results provide an up-to-date summary of the association between genetic variants and response to PBC in NSCLC patients.
Factors Determining in The Selection of Pediatrics Health Care Service in Chennai, India

Background: Parents can choose their children's healthcare center; however, the healthcare business struggles to meet the growing health demands of vulnerable groups. Pediatricians now prioritize parental interests to improve their services and healthcare. This study also determined the association of sociodemographic variables with factors influencing the parent's decision. Materials and Methods: A cross-sectional study was undertaken among 146 parents of children aged 0 to 13 years who sought-patient services at a paediatrics department of a tertiary care center in Chennai between July 2023 to October 2023. The Validated semi structured questionnaire was administered. Results: In the present study, mean age group of the study population is 29±4, among them 69% were female and 31% were male. Sociodemographic variables, namely younger age, female gender, middle monthly income, and higher educational status, are influential in the parent's decision-making process for selecting a health care center. Conclusion: Although parents may lack the ability to assess all facets of care and treatment, their perspectives contribute immensely to the interpersonal aspect of care, communication, information, and care organization. The present study has yielded significant results that enhance the knowledge base of practitioners, managers, and other professionals tasked with delivering pediatrics general practice services.
Association between high-density lipoprotein cholesterol and type 2 diabetes mellitus: dual evidence from NHANES database and Mendelian randomization analysis

Background Low levels of high-density lipoprotein cholesterol (HDL-C) are commonly seen in patients with type 2 diabetes mellitus (T2DM). However, it is unclear whether there is an independent or causal link between HDL-C levels and T2DM. This study aims to address this gap by using the The National Health and Nutrition Examination Survey (NHANES) database and Mendelian randomization (MR) analysis. Materials and methods Data from the NHANES survey (2007-2018) with 9,420 participants were analyzed using specialized software. Logistic regression models and restricted cubic splines (RCS) were used to assess the relationship between HDL-C and T2DM incidence, while considering covariates. Genetic variants associated with HDL-C and T2DM were obtained from genome-wide association studies (GWAS), and Mendelian randomization (MR) was used to evaluate the causal relationship between HDL-C and T2DM. Various tests were conducted to assess pleiotropy and outliers. Results In the NHANES study, all groups, except the lowest quartile (Q1: 0.28-1.09 mmol/L], showed a significant association between HDL-C levels and reduced T2DM risk (all P < 0.001). After adjusting for covariates, the Q2 [odds ratio (OR) = 0.67, 95% confidence interval (CI): (0.57, 0.79)], Q3 [OR = 0.51, 95% CI: (0.40, 0.65)], and Q4 [OR = 0.29, 95% CI: (0.23, 0.36)] groups exhibited average reductions in T2DM risk of 23%, 49%, and 71%, respectively. In the sensitivity analysis incorporating other lipid levels, the Q4 group still demonstrates a 57% reduction in the risk of T2DM. The impact of HDL-C levels on T2DM varied with age (P for interaction = 0.006). RCS analysis showed a nonlinear decreasing trend in T2DM risk with increasing HDL-C levels (P = 0.003). In the MR analysis, HDL-C levels were also associated with reduced T2DM risk (OR = 0.69, 95% CI = 0.52-0.82; P = 1.41 × 10-13), and there was no evidence of pleiotropy or outliers. Conclusion This study provides evidence supporting a causal relationship between higher HDL-C levels and reduced T2DM risk. Further research is needed to explore interventions targeting HDL-C levels for reducing T2DM risk.
The Photo Manipulation from the Perspective of Photographers: Study from Jordan

From both positive and negative perspectives, photo manipulation has an impact on all areas of photography. Although the effect of photo manipulation is a personal matter, the effect of its application is reflected in the type of audience that consumes the image. Therefore, the research aims to study photographers' understanding of image manipulation and its ethics, in addition to identifying image manipulation techniques from the photographers' professional point of view. A total of 228 responses were obtained using the online questionnaire. The results of the study indicate that photographers consider photo manipulation as one of the elements responsible for losing the credibility of photography and the image. However, the respondents agreed that unethical photo manipulation is an issue of increasing importance in the photography community, and they identified the need for ethical conduct in all genres of photography in order to reduce wrong practices. The results also show that manipulation techniques that do not harm the content of image are acceptable to photographers.
Factors Influencing the Morphological Characteristics of Village Chickens’ Genetic Resources in the Abu-Dhabi Emirate, UAE

The study was accomplished to identify the characteristics of village chickens’ (VCs) genetic resources in the Abu-Dhabi Emirate of United Arab Emirate (UAE) and to study factors affecting these characteristics. Each bird was individually observed, identified, measured and characterized of thirteen VCs pure breeds and crossbreds. The overall VCs had normal feather morphology (95.1%) and distribution (77%). Except for Fayomi chickens which were 100% mottled, no specific plumage pattern was found. Almost 52% of the VCs had white skins. Six different colors were reported for the shanks and maximized for white shanks (34.3%). Large breasts (46%) were more available. The predominant plumage color was mixed colors (37.5%). Face size tended to be small (42.8%) to medium (40.4%). More brown (48.9%) then orange (27.3%) eyes were found. Dark (49.7%) beaks were more available than white (28.6%) or yellow (21.7%) beaks. The distribution of wattle colors was similar to that of ear-lob colors with some variation. Small wattles (41.9%) were most available. Single comb (82.4%) is the most available; 11 other types and one with no comb were represented with low frequencies. In the whole sample, red and white combs (56.7%) were the most available; however, plain red (23.8%) and red and black (15.5%) were represented. Results of factors influence showed that body weight was high significantly (P P as observed between breed and location on body length, wing span and shank length. The interaction between breed and sex only significantly (P P P < 0.01) different among breeds. This study reported the morphological characteristics of the different VCs breeds kept in Abu-Dhabi Emirate, which considered the scientific base for future implementing of conservation and/or genetic improvement programs.
Genetics and molecular biology.

COVID-19 comprises clinical outcomes of SARS-CoV-2 infection and is highly heterogeneous, ranging from asymptomatic individuals to deceased young adults without comorbidities. There is growing evidence that host genetics play an important role in COVID-19 severity, including inborn errors of immunity, age-related inflammation and immunosenescence. Here we present a brief review on the known order of events from infection to severe system-wide disturbance due to COVID-19 and summarize potential candidate genes and pathways. Finally, we propose a strategy of subject’s ascertainment based on phenotypic extremes to take part in genomic studies and elucidate intrinsic risk factors involved in COVID-19 severe outcomes.
Arteriosclerosis, Thrombosis, and Vascular Biology

BACKGROUND: Anti-β 2GP1 ( β 2-glycoprotein 1) antibodies are the primary pathogenic antibody to promote thrombosis in antiphospholipid syndrome (APS), yet the underlying mechanism remains obscure. We aimed to explore the intracellular pathway that mediated platelet activation. METHODS: Platelets were isolated from patients with APS and subjected to RNA sequencing. Platelet aggregation, the release of platelet granules, platelet spreading, and clot retraction were detected to evaluate platelet activation. We purified anti-β 2GP1 antibodies from patients with APS and the total IgG from healthy donors to stimulate platelets with/without Fc γ RIIA (Fc γ receptor IIA) blocking antibody or Akt (protein kinase B) inhibitor. Platelet-specific Sin1 (stress-activated protein kinase–interacting protein) deficiency mice were established. The thrombus model of inferior vena cava flow restriction, ferric chloride–induced carotid injury model, and laser-induced vessel wall injury in cremaster arterioles model were constructed after administration of anti-β 2GP1 antibodies. RESULTS: Combined RNA sequencing and bioinformatics analysis suggested that APS platelets exhibited increased levels of mRNA associated with platelet activation, which was in line with the hyperactivation of APS platelets in response to stimuli. Platelet activation in APS platelets was accompanied by upregulation of the mTORC2 (mammalian target of the rapamycin complex 2)/Akt pathway and increased levels of SIN1 phosphorylation at threonine 86. Anti-β 2GP1 antibody derived from patients with APS enhanced platelet activation and upregulated the mTORC2/Akt pathway. Moreover, the Akt inhibitor weakened the potentiating effect of the anti-β 2GP1 antibody on platelet activation. Notably, Sin1 deficiency suppresses anti-β 2GP1 antibody–enhanced platelet activation in vitro and thrombosis in all 3 models. CONCLUSIONS: This study elucidated the novel mechanism involving the mTORC2/Akt pathway, which mediates the promotion of platelet activation and induction of thrombosis by the anti-β 2GP1 antibody. The findings suggest that SIN1 may be a promising therapeutic target for the treatment of APS. GRAPHIC ABSTRACT