Miracle-dz/UniFAR-FTUs huggingface dataset:
Twenty-year experience of atrial fibrillation ablation: a single-centre cohort study

Abstract Aims While several studies in the literature have reported results of catheter ablation of AF, few is known regarding outcome for more than 10 years. Methods and results The complete population of patients who underwent AF ablation in the years 2002–2021 in the department of cardiology of the hospital of Reggio Emilia has been analysed. The last follow-up was made in the second half of 2022. During this period the technique of ablation remained relatively unchanged as well the physicians performing ablation. Primary endpoint was the recurrence of symptomatic AF, defined as AF that caused symptoms that were defined by the patient as able to alter their quality of life. 669 patients underwent catheter ablation and 618 were followed until 2022. Median age of the patients was 58 ± 9 years and 521 (78%) were male. There were 407 (61%) of patients with paroxysmal AF, 167 (25%) with persistent AF and 95 (14%) with long-lasting AF. A total of 838 procedures were performed, with a mean of 1.25 per patient. 163 (26%) patients had 2 procedures and 6 had 3 ablations. Periprocedural complications occurred in 4.8% of procedures. Follow-up data were available for 618 patients (92.4%). The median follow-up duration was 6.6 years (IQR 3.2–10.8). The estimated recurrence rate of symptomatic AF was 26% at 10 years, 54% at 15 years and 82% at 20 years. The recurrence rate was similar in patients who had performed one procedure and in those who had performed 2 or 3 procedures. Progression to permanent AF occurred in 112 patients (18%). The major events that occurred during the follow-up consisted of total mortality in 4.5%, heart failure in 3.1% and TIA/stroke in 2.4%. Conclusion Symptomatic AF tends to recur during long-term follow-up despite one or more procedures. Catheter ablation seems able to reduce the rate of symptomatic recurrences and to delay the time of their occurrence. These findings are consistent with the knowledge that an age-dependent progressive structural atriomiopathy is the basis for the development of AF.
Life history parameters of Bemisia tabaci MED (Hemiptera: Aleyrodidae) in the present and future climate of central Europe, predicted by physically realistic climatic chamber simulation

Whiteflies of the Bemisia tabaci species complex are among the most damaging insect pests in agriculture worldwide, causing damage by feeding on crop plants and by vectoring plant viruses. The species complex consists of over 35 cryptic species that differ in many aspects of their biology including the optimal environment, geographic distribution, and host range. Global warming and associated climate change resulting from human activities is expected to contribute to biological invasions. Bemisia tabaci species show fast adaptability to changes in agroecosystems and have a long record of biological invasions. Climate change driven increase in B. tabaci importance in agricultural systems of Europe has been predicted, but so far not experimentally tested.The present study evaluates the development of B. tabaci MED (=Mediterranean) in a climatic chamber simulation of the future climate in Luxembourg, chosen as a representative region for the Central Europe. Future climate predictions for the period 2061–2070 were derived from a multimodel ensemble of physically consistent regional climatic models. Results show a 40% shorter development time of this important pest in future climatic conditions, with an increase in fecundity by a third, and insignificant difference in mortality. Accelerated development, combined with its already established year-round presence in European greenhouses and predicted northward expansion of outdoor tomato production in Europe, means faster population build-up at the beginning of the outdoor cropping season with the potential of reaching economic importance. Benefits of simulating hourly diurnal cycle of physically consistent meteorological variables versus previous experiments are discussed.
Epidemiology of chemical burns: An 11‐year retrospective study of 126 patients at a referral burn centre in the north of Iran

The etiology and outcomes of chemical burns vary worldwide, influenced by the local population structure, industry distribution, and geographical and social environments. The aim of this study was to evaluate the epidemiology of chemical burns among patients referred to a burn centre in the north of Iran. A single‐centre, retrospective study was conducted on patients with chemical burns between 2011 and 2021. Data collection was carried out using the hospital information system (HIS), and data collected from medical records included gender, age, marital status, occupations, burn season, place of residence, intention to burn, location of the accident, percent of total body surface area (%TBSA), the primary cause of burns, the body region of the burn, length of hospital stay (days), infection, and discharge status. The data were analysed using descriptive statistical methods and SPSS 24.0 software. Of the 10 133 burn patients treated in a burn centre in the north of Iran between 2011 and 2021, 1.2% had chemical burns. The average age of patients was 34.45 (SD = 22.16) years, and most chemical burns cases were male (70.6%, n = 89). Chemical burns occurred most frequently in patients aged 20 to 49 years (69.8%, n = 107), and most of the burns were accidental (84.9%, n = 107). The home was the most common place of chemical burn injury, accounting for 49.2% (62 cases), followed by the workplace (43.7%, n = 55), respectively. Most chemical burns occurred in the summer season (36.5%, n = 46), and acid (74.6%, n = 94) was the most common cause of chemical burns. The mean TBSA was 16.41 (SD = 15.10). The most common burn area was the lower limb (34.9%, n = 44), and the overall mortality rate was 4.8%. The average length of stay in the hospital was 6.53 (SD = 5.57) days. Community education on household safety, restricting non‐specialists' access to chemical substances, and the promotion of early consultation could reduce chemical burn prevalence and improve outcomes.
The use of concrete learning objects taken from the history of mathematics in mathematics education

ABSTRACT This study aimed to reveal the effects of teaching with concrete learning objects taken from the history of mathematics on student achievement. Being a quasi-experimental study, it was conducted with two grade 8 classes in a secondary school located in Trabzon. The experimental group consisted of 27 students and the control group consisted of 25. Data were collected by using worksheets, an achievement exam and written opinion forms. The data from the achievement exam were analysed by using the Mann-Whitney U-test while the data from written opinion forms were analysed through content analysis. The Mann–Whitney U-test results showed a significant difference between the mean ranks of the experimental and control groups in favour of the former. Findings from the written opinion forms suggested that the students found the activities to be instructive and fun, enjoyed using concrete models in their classes, and learned from discovering the rules. It was also found that students had previously not engaged in similar activities and had only experienced the history of mathematics through the life stories and works of mathematicians and the representation of ancient numbers at the beginning of each unit.
When Disclosure Fails to Substantiate Abuse: Child and Perpetrator Race Predict Child Sexual Abuse Substantiation

We examined the effects of child race, perpetrator race, and abuse disclosure status (within the context of a formal forensic interview) on abuse substantiation outcomes. Specifically, we coded child sexual abuse disclosure, abuse substantiation, and race of 315 children (80% girls, M age = 10, age range = 2–17; 75% White, 9% Black, 12% Biracial, 3% Hispanic, 1% Asian) who underwent a child forensic interview in a Midwestern child advocacy center. Supporting hypotheses, abuse substantiation was more likely in cases involving (a) abuse disclosure (vs. no disclosure), (b) White children (vs. children of color), and (c) perpetrators of color (vs. White perpetrators). Also supporting hypotheses, the effect of abuse disclosure on increased abuse substantiation was greater for White children than for children of color. This research suggests that even when children of color disclose their experiences of sexual abuse, they nonetheless face barriers to abuse substantiation.
Viral target and metabolism‐based rationale for combined use of recently authorized small molecule COVID‐19 medicines: Molnupiravir, nirmatrelvir, and remdesivir

The COVID‐19 pandemic remains a major health concern worldwide, and SARS‐CoV‐2 is continuously evolving. There is an urgent need to identify new antiviral drugs and develop novel therapeutic strategies. Combined use of newly authorized COVID‐19 medicines including molnupiravir, nirmatrelvir, and remdesivir has been actively pursued. Mechanistically, nirmatrelvir inhibits SARS‐CoV‐2 replication by targeting the viral main protease (Mpro), a critical enzyme in the processing of the immediately translated coronavirus polyproteins for viral replication. Molnupiravir and remdesivir, on the other hand, inhibit SARS‐CoV‐2 replication by targeting RNA‐dependent RNA‐polymerase (RdRp), which is directly responsible for genome replication and production of subgenomic RNAs. Molnupiravir targets RdRp and induces severe viral RNA mutations (genome), commonly referred to as error catastrophe. Remdesivir, in contrast, targets RdRp and causes chain termination and arrests RNA synthesis of the viral genome. In addition, all three medicines undergo extensive metabolism with strong therapeutic significance. Molnupiravir is hydrolytically activated by carboxylesterase‐2 (CES2), nirmatrelvir is inactivated by cytochrome P450‐based oxidation (e.g., CYP3A4), and remdesivir is hydrolytically activated by CES1 but covalently inhibits CES2. Additionally, remdesivir and nirmatrelvir are oxidized by the same CYP enzymes. The distinct mechanisms of action provide strong rationale for their combined use. On the other hand, these drugs undergo extensive metabolism that determines their therapeutic potential. This review discusses how metabolism pathways and enzymes involved should be carefully considered during their combined use for therapeutic synergy.
The effects of temporal envelope confusion on listeners' phoneme and word recognition

Broadened auditory filters in listeners with hearing loss may result in listeners' increased reliance on temporal envelope cues for understanding speech. Previous data have shown that background noise may affect hearing-impaired (HI) listeners by negatively affecting the temporal envelope cues in speech. The current study investigates additional HI listeners? understanding of vocoded spondees in the presence of fluctuating and stationary background noise. Stimuli were 8- and 32-channel noise vocoded double spondees, high-pass filtered at 1426 Hz. New data confirmed the previous finding that temporal envelope confusion in HI listeners resulted in speech understanding that is poorer in fluctuating noise (at a rate of 4Hz) than in stationary noise. Preliminary analysis suggests HI listeners experience significant envelope confusion for both 8- and 32-channel vocoded stimuli. Additional analysis of phoneme errors suggests that envelope confusion affects HI listeners' perception of both consonants and vowels.
The function of plant PR1 and other members of the CAP protein superfamily in plant–pathogen interactions

Abstract The pathogenesis‐related (PR) proteins of plants have originally been identified as proteins that are strongly induced upon biotic and abiotic stress. These proteins fall into 17 distinct classes (PR1–PR17). The mode of action of most of these PR proteins has been well characterized, except for PR1, which belongs to a widespread superfamily of proteins that share a common CAP domain. Proteins of this family are not only expressed in plants but also in humans and in many different pathogens, including phytopathogenic nematodes and fungi. These proteins are associated with a diverse range of physiological functions. However, their precise mode of action has remained elusive. The importance of these proteins in immune defence is illustrated by the fact that PR1 overexpression in plants results in increased resistance against pathogens. However, PR1‐like CAP proteins are also produced by pathogens and deletion of these genes results in reduced virulence, suggesting that CAP proteins can exert both defensive and offensive functions. Recent progress has revealed that plant PR1 is proteolytically cleaved to release a C‐terminal CAPE1 peptide, which is sufficient to activate an immune response. The release of this signalling peptide is blocked by pathogenic effectors to evade immune defence. Moreover, plant PR1 forms complexes with other PR family members, including PR5, also known as thaumatin, and PR14, a lipid transfer protein, to enhance the host's immune response. Here, we discuss possible functions of PR1 proteins and their interactors, particularly in light of the fact that these proteins can bind lipids, which have important immune signalling functions.
Axillary lymph node recurrence following wire‐directed sentinel lymph node dissection for breast cancer patients with biopsy‐proven axillary metastases prior to neoadjuvant chemotherapy at a safety net medical center

Although sentinel lymph node dissection (SLND) after neoadjuvant chemotherapy (NAC) is feasible, axillary management for patients with pretreatment biopsy‐proven axillary metastases and who are clinically node‐negative after NAC (ycN0) remains unclear. This retrospective study was performed to determine the rate of axillary lymph node recurrence for such patients who had wire‐directed (WD) SLND.
Ultrastructure and histochemistry of the scolex of two Neotropical proteocephalidean species (Cestoda: Onchoproteocephalidea)

The internal ultrastructure of the scolex and the histochemical composition of the apical glands of two South American proteocephalideans cestodes, Monticellia magna and Proteocephalus pimelodi, were described for the first time. The study included the use of scanning and transmission electron microscopy to observe the tegumental ultrastructure, and histochemical techniques to detect types of gland secretion. Two types of glands were found in the scolex of M. magna and P. pimelodi. The pattern of microtriches described for M. magna was confirmed and that of P. pimelodi was described for the first time. Also, the internal ultrastructure of the microtriches in both species was described. Indications of the presence of sensory receptors were also found in M. magna. Finally, the systematic value of the characters studied is discussed, such as the internal structure of the gladiate spinitriches and the apocrine gland of M. magna.
Prediction and prevention of the first episode of overt hepatic encephalopathy in patients with cirrhosis

Hepatic encephalopathy (HE) is one of the most important complications of patients with liver cirrhosis. In addition, HE is associated with a dismal prognosis and has detrimental effects on patients’ quality of life. Thus, it is of pivotal importance to identify patients at high risk for overt HE (OHE) in whom primary prophylaxis may be justified. In this narrative review, we aim to provide insight into predictors and prediction tools for a first-time episode of OHE and to scrutinize the current level of evidence of primary prophylaxis. In recent decades, several cognitive tests, composite scores, and blood-based biomarkers have been demonstrated to be predictive of a first-time episode of OHE. Among the best validated are the established tests for minimal HE, such as the Psychometric Hepatic Encephalopathy Score, determination of the critical flicker frequency, Stroop EncephalApp, or the Animal Naming Test. Individualized risk stratification using blood-based biomarkers and cross-sectional imaging (sarcopenia and spontaneous portosystemic shunts) is coming to the fore, but validation in larger multicenter cohorts is often lacking. On the basis of current evidence, a recommendation for primary prophylaxis of a first episode of OHE cannot be made in general. Only 2 studies have investigated the prevention of a first-time OHE episode as the primary endpoint. In this narrative review, we provide a concise overview of the current evidence levels on prediction tools and pharmacological prevention of a first episode of OHE. In addition, we give an outlook on future research targets to improve knowledge on this important topic.
The near wall jet of a normally impinging, uniform, axisymmetric, supersonic jet

The near wall jet produced by directing a uniform axisymmetric jet of air normally onto a large flat plate has been investigated experimentally and theoretically for four jets in the Mach number range 1·64–2·77. Detailed measurements of the surface pressure and shadowgraph and surface flow pictures are presented. The results show that the mechanism which mainly determines the supersonic near wall jet is the jet-edge expansion and its reflexions from the sonic line and the wall-jet boundaries. The near wall jet is found to consist of an alternating series of expansion and recompression regions whose strengths depend on the jet Mach number and decay with distance. At Mach numbers of 2·4 and above, shock waves are observed in the first recompression region and at a Mach number of 2·77 the boundary layer separates locally. Further out, viscous effects become increasingly important and a constant-pressure shear flow is established at a distance which increases with jet Mach number. The application of the method of characteristics in an approximate manner reproduces a number of the features of the near wall jet which are observed experimentally. Pressure distributions obtained in the shock layer show that a stagnation bubble can occur and that its occurrence depends on factors such as the flow upstream of the nozzle. The wall-jet region is found to be largely independent of whether or not a bubble occurs in the shock layer.
Alpha‐tACS alters attentional control but not cognitive functions as video games do: A psychophysical investigation based on the theory of visual attention

Video game players' faster speed of information processing has been shown to coincide with altered posterior alpha power modulation, that is, brain oscillatory activity around 10 Hz. Thus, it was proposed that improved cognitive processing in video game players may be related to differential alpha activity. However, a causal relationship thereof has not yet been established. We addressed this by conducting a non‐invasive brain stimulation study to demonstrate that modulating alpha power using transcranial alternating current stimulation (tACS) may impact on speed of information processing. Furthermore, we aimed to show that this effect correlated with altered attentional control, for example, visuospatial attention and/or top‐down control processing, given that this has been suggested to contribute to video gaming effects. Therefore, we recruited 19 non‐video game players to undergo one of five brain stimulation conditions while performing a visual short‐term memory task at five different days, respectively. Thus, we applied tACS either at 10 Hz (alpha frequency) or at 16.18 Hz (control frequency) either over their left or right posterior parietal cortex (PPC) or a sham stimulation. Individuals' speed of information processing, visuospatial attention and top‐down control processing were operationalised using a computational modelling approach based on the theory of visual attention. We found that alpha‐tACS applied over individuals' left PPC altered their visuospatial attention orientation but not their speed of information processing. Thus, we were not able to establish a causal relationship between speed of information processing and altered visuospatial attention processing through alpha power modulation using non‐invasive brain stimulation.
Geometrical frustration and quantum origin of spin dynamics

This Phd thesis focuses on the study of magnetically frustrated compounds where magnetic ions lie at the vertices of a corner-sharing tetrahedra network: the pyrochlore compounds. The two series of chemical formula R2M2O7, where R is a lanthanide and M=Ti, Sn, are of peculiar interest since they display a large variety of exotic magnetic ground states. First, we have studied the crystal-electric-field acting at the rare earth within the Stevens approximation where only the ground state multiplet is considered. A single set of parameters for each families of interest has been determined through a global analysis including several inelastic neutron scattering spectra of various compounds. Then, we have characterised with a large panel of techniques the low temperature physical properties of Nd2Sn2O7. This compound enters a long-range magnetic order at transition temperature Tc=0.91 K with an ``all-in-all-out'' spin configuration. A persistence of spin dynamics has been found in the ordered phase, ascribed to one-dimensional spin loops excitations. Anomalously slow paramagnetic spin fluctuations are also reported. Finally, we have brought information on the two proposed ground states of the widely studied compound Tb2Ti2O7: first, a Jahn-Teller transition is claimed to occur at low temperatures but no broadening of the Bragg peaks is seen down to T=4 K precluding premises of a structural transition. Secondly, this compound could be a realisation of a quantum spin-ice but no definitive evidence of a magnetisation plateau is found down to T=20 mK.
The correlation between non-arteritic anterior ischemic optic neuropathy and cerebral infarction

Abstract Background The aim of this study was to explore the correlation between non-arteritic anterior ischemic optic neuropathy (NAION) and cerebral infarction (CI). Moreover, the ocular and systemic parameters are also compared between NAION patients with or without CI. Methods Retrospective analysis is performed for NAION patients and the controls. The controls were collected at the eye outpatient with cranial computed tomography (CT), and data of blood triglyceride, cholesterol, low-density lipoprotein, high-density lipoprotein, and apolipoprotein B were drawn. The diagnosed NAION patients with cranial CT are included, and data of clinical history and routine clinical examination were drawn from the medical record. Visual acuity, intraocular pressure (IOP), visual field, and visual evoked potential were also drawn. Results Eighty-two unilateral and 6 bilateral patients, totally 94 eyes for 88 NAION patients and 69 controls are included. NAION and control patients have matched age, gender, and weight. There is no difference in triglyceride, cholesterol, low-density lipoprotein, high-density lipoprotein, and apolipoprotein B between these two groups. NAION patients (43.18%, 38/88) have a higher ratio of CI than the controls (14.49%, 10/69) (p = 0.000). For NAION, the odds ratio (OR) of CI is 2.691 (p = 0.011). Body mass index, height, and IOP show no significant difference between NAION patients with or without CI. NAION patients with CI have a significant higher ratio of hypertension than those without CI, and the OR of HBP is 2.623 (p = 0.008). Conclusions The correlation between NAION and CI is possible as NAION patients have a significant higher ratio with CI. In NAION patients, hypertension is a risk factor for those with CI.