Miracle-dz/UniFAR-FTUs huggingface dataset:
Senescence-Driven Inflammatory and Trophic Microenvironment Imprints Mesenchymal Stromal/Stem Cells in Osteoarthritic Patients

Senescent cells promote progressive tissue degeneration through the establishment of a combined inflammatory and trophic microenvironment. The cellular senescence state has therefore emerged as a central driving mechanism of numerous age-related diseases, including osteoarthritis (OA), the most common rheumatic disease. Senescence hallmarks are detectable in chondrocytes, synoviocytes and sub-chondral bone cells. This study investigates how the senescence-driven microenvironment could impact the cell fate of resident osteoarticular mesenchymal stromal/stem cells (MSCs) that are hence contributing to OA disease progression. For that purpose, we performed a comparative gene expression analysis of MSCs isolated from healthy donors that were in vitro chronically exposed either to interferon-gamma (IFN-γ) or Transforming Growth Factor beta 1 (TGFβ1), two archetypical factors produced by senescent cells. Both treatments reduced MSC self-renewal capacities by upregulating different senescence-driven cycle-dependent kinase inhibitors. Furthermore, a common set of differentially expressed genes was identified in both treated MSCs that was also found enriched in MSCs isolated from OA patients. These findings highlight an imprinting of OA MSCs by the senescent joint microenvironment that changes their matrisome gene expression. Altogether, this research gives new insights into OA etiology and points to new innovative therapeutic opportunities to treat OA patients.
Glycated haemoglobin in the first year after diagnosis of type 1 diabetes is an independent risk factor for diabetic retinopathy: The IMDIAB 25 years follow‐up study

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Diabetes unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy Research Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Rome, Italy Diabetes Unit, Sandro Pertini Hospital, Rome, Italy Diabetes unit, Santo Spirito Hospital, Rome, Italy Endocrinology and Diabetes Unit, Bambino Gesù Hospital Research Institute, Rome, Italy
Semiparametric Quantile Averaging in the Presence of High-Dimensional Predictors

Abstract The paper proposes a method for forecasting conditional quantiles. In practice, one often does not know the “true” structure of the underlying conditional quantile function, and in addition, we may have a large number of predictors. Focusing on such cases, we introduce a flexible and practical framework based on penalized high-dimensional quantile averaging. In addition to prediction, we show that the proposed method can also serve as a predictor selector. We conduct extensive simulation experiments to asses its prediction and variable selection performances for nonlinear and linear time series model designs. In terms of predictor selection, the approach tends to select the true set of predictors with minimal false positives. With respect to prediction accuracy, the method competes well even with the benchmark/oracle methods that know one or more aspects of the underlying quantile regression model. We further illustrate the merit of the proposed method by providing an application to the out-of-sample forecasting of U.S. core inflation using a large set of monthly macroeconomic variables based on FRED-MD database. The application offers several empirical findings.
Outcome Analysis of Conservative Management of Acute Calculus Cholecystitis in Addis Ababa University Teaching Hospitals Addis Ababa, Ethiopia: Retrospective Study

: Back ground: cholecystectomy for an acutely inflamed gall bladder is accompanied with significant perioperative complications Conservative (non operative management) is considered to be the standard of care mainly in the developed world . Non operative management is still widely practiced in many developing countries including Ethiopia. This study aimed to assess the outcome of such a conservative management in teaching hospitals Addis Ababa, Ethiopia. Method: Hospital based cross-sectional study design was conducted. Data was entered and analyzed by SPSS version 20. Chi-square, binary logistic regression, at 95% CI and P-value <0.05 were used to examine relationship between dependent and independent variables. Results: A total of 134 cases were admitted. In this study the mean age is 41.67, (95% CI 39.5 to 43.9) and M: F ratio is 1:2.2 and Age of the patients ranged between 15-80 years and majority of them were in the age group of 35-44 (32.1%) years. Conservative treatment during index admission was successful in 96.27% of the cases but mean duration of hospital stay 5.54 days, 95% CI (5.03, 6.05) . Duration of illness before (OR = 3.47: 1.26-9.55 ) and Duration of hospital stay (OR = 1.92: 1.28-2.87) were determinant factors for index admission. 19% of patients encountered complication while waiting for cholecystectomy. Comorbidity ( AOR = 4.06: 1.49 - 11.07; value = 0.006 ). GB stone impacted at the neck ( AOR = 3.39: (1.259-9.13); value = 0.016) were associated factors identified. In this study out of 131 cases treated and discharged improved and appointed for interval-cholecystectomy only 71.7% of them had interval -cholecystectomy in two-year period. The rest 13 (9.7%) patients did not show up follow up after admission booked (registered under waiting list for bed). 3 patients died with complications directly or indirectly related to conservative management cholecystitis. Conclusion and Recommendations : this study revealed patients arrival to hospital is delayed and also stayed prolonged time in the hospital. significant number of patients also developed complications while waiting for interval cholecystectomy and also significant Number of patients did not get cholecystectomy service. Nationwide introduction of emergency laparoscopic cholecystectomy and Patient referral system, admission, discharge and follow up system needs revision.
Beyond Plausibly Exogenous

We synthesize two recent advances in the literature on instrumental variables (IVs) estimation that test and relax the exclusion restriction. Our approach first estimates the direct effect of the IV on the outcome in a subsample for which the IV does not affect the treatment variable. Subsequently, this estimate for the direct effect is used as input for the plausibly exogenous method developed by Conley, Hansen and Rossi (2012). This two-step procedure provides a novel and informed sensitivity analysis for IV estimation. We illustrate the practical use by estimating the causal effect of (i) attending Catholic high school on schooling outcomes, and (ii) the number of children on female labour supply.
Unlocking the Optimal Analgesic Potential: A Systematic Review and Meta-Analysis Comparing Intravenous, Oral, and Rectal Paracetamol in Equivalent Doses

Paracetamol (acetaminophen) is an extensively used analgesic for acute and chronic pain management. Currently, paracetamol is manufactured for oral, rectal, and intravenous (IV) use. Research has shown varied results on the analgesic properties of IV paracetamol compared to oral and rectal paracetamol; however, research on the same doses of paracetamol is limited. Therefore, this review was constructed to explore the analgesic properties of IV paracetamol compared with oral and rectal paracetamol administered in equivalent doses. A broad and thorough literature search was performed on five electronic databases, including PubMed, ScienceDirect, Medline, Scopus, and Google Scholar. Statistical analysis of all outcomes in our review was then performed using the Review Manager software. Outcomes were categorized as primary (pain relief and time to request rescue analgesia) and secondary (adverse events after analgesia). An extensive quality appraisal was also done using the Review Manager software’s Cochrane risk of bias tool. The literature survey yielded 2,945 articles, of which 12 were used for review and analysis. The pooled analysis for patients undergoing surgical procedures showed that IV paracetamol had statistically similar postoperative pain scores at two (mean difference (MD) = -0.14; 95% confidence interval (CI) -0.58-0.29; p = 0.51), 24 (MD = 0.09; 95% CI = -0.02-0.21; p = 0.12), and 48 (MD = 0.04; 95% CI = -0.08-0.16; p = 0.52) hours as oral paracetamol. Similarly, the data on time to rescue analgesia showed no considerable difference between the IV and oral paracetamol groups (MD = -1.58; 95% CI = -5.51-2.35; p = 0.43). On the other hand, the pooled analysis for patients presenting non-surgical acute pain showed no significant difference in the mean pain scores between patients treated with IV and oral paracetamol (MD = -0.35; 95% CI = -2.19-1.48; p = 0.71). Furthermore, a subgroup analysis of analgesia-related adverse events showed that the incidences of vomiting/nausea and pruritus did not differ between patients receiving IV and oral paracetamol (odds ratio (OR) = 0.71; 95% CI = 0.45-1.11; p = 0.13 and OR = 0.48; 95% CI = 0.18-1.29; p = 0.05, respectively). A review of information from two trials comparing equal doses of IV and rectal paracetamol suggested that the postoperative pain scores were statistically similar between the groups. IV paracetamol is not superior to oral or rectal paracetamol administered in equal doses. Therefore, we cannot recommend or refute IV paracetamol as the first-line analgesia for acute and postoperative pain.
Firm‐specific Human Capital Accumulation: Evidence from Brazil*

We introduce ﬁrm-speciﬁc returns to experience and tenure into a standard two-way ﬁxed eﬀects model, show that they are separately identiﬁed under the standard exogenous mobility assumption and provide new evidence on heterogeneity of returns to experience and tenure across ﬁrms using the administrative matched employer-employee data from Brazil over the years 1999-2014. We ﬁnd substantial variation in experience and tenure returns across ﬁrms with average return to 5 years of seniority equal to 11.4%. Moreover, we document that 1) returns to tenure are not strongly related to ﬁrm wage premia (i
BENTUK AFIKSASI RAGAM BAHASA REMAJA DALAM NOVEL MARMUT MERAH JAMBU KARYA RADITYA DIKA

The purpose of this study was to describe about: 1) forms the prefixs to the mark language diversity in Marmut Merah Jambu novel works Raditya Dika, 2) forms suffixes that mark the language diversity in Marmut Merah novel works Raditya Dika. The method used descriptive, qualitative approach, data collection methods see and record. The research found that affixes the prefix form there are two types of di- and nge-. Prefix language diversity was a teenager the same function as the prefix di- in Indonesian that raw form a passive verb. Prefix nge- synonymous with the prefix meN- in Indonesian profound, but the change in shape adapted to the words that follow and functions to form an active verb. Suffix forms found in four types: -in, -i, nya, -an. Suffix -in suffix synonym with suffix -kan in Indonesian. Its function is twofold can form a transitive verb and a verb intransitive. Transitive verb requires an object, being verb intransitive object does not appear. Suffix -i, nya, and -an, synonymous suffix -i, nya, -an Indonesian. Suffix -in which form the verb monotransitive, because it has one object. Suffixes –nya to form words task. Suffix -an forming a passive verb.
miR-124 as a Liquid Biopsy Prognostic Biomarker in Small Extracellular Vesicles from NSCLC Patients

Despite advances in non-small cell lung cancer (NSCLC) research, this is still the most common cancer type that has been diagnosed up to date. microRNAs have emerged as useful clinical biomarkers in both tissue and liquid biopsy. However, there are no reliable predictive biomarkers for clinical use. We evaluated the preclinical use of seven candidate miRNAs previously identified by our group. We collected a total of 120 prospective samples from 88 NSCLC patients. miRNA levels were analyzed via qRT-PCR from tissue and blood samples. miR-124 gene target prediction was performed using RNA sequencing data from our group and interrogating data from 2952 NSCLC patients from two public databases. We found higher levels of all seven miRNAs in tissue compared to plasma samples, except for miR-124. Our findings indicate that levels of miR-124, both free-circulating and within exosomes, are increased throughout the progression of the disease, suggesting its potential as a marker of disease progression in both advanced and early stages. Our bioinformatics approach identified KPNA4 and SPOCK1 as potential miR-124 targets in NSCLC. miR-124 levels can be used to identify early-stage NSCLC patients at higher risk of relapse.
Student learning discipline: Problem and solution in online learning

Learning activities to develop students' character learning discipline at the junior high school level has given rise to difficulties for teachers and students. The paper aims to describe the form of student learning discipline behavior and analyze the role of teachers and principals during the learning process. The article is based on data collected from the results of the spread of open questionnaires to 30 students in three schools in East Java province. In addition, the research data was also obtained through interviews with 12 teachers and two principals. The results showed that principals and teachers have a significant role in determining the success of online learning. The principal's role in making flexible policies has been a determinant of the success of online learning. Likewise, the positive attitude of teachers towards students has contributed to the successful development of student learning disciplines. The paper suggests the need for more in-depth data retrieval methods to understand cases better.
An application of the put-call-parity to variance reduced Monte-Carlo option pricing

The standard error of Monte Carlo estimators for derivatives typically decreases at a rate proportional to N^-0.5 where N is the sample size.To reduce empirical variance for estimators of several in-the-money options an application of the putcall- parity is analyzed. Instead of directly simulating a call option, first the corresponding put option is simulated. By employing the put-call-parity the desired call price is calculated. Of course, the approach can also be applied vice versa. By employing this approach for in-the-money options, significant variance reductions are observed.
Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells

A series of novel 3-(prop-1-en-2-yl)azetidin-2-one, 3-allylazetidin-2-one and 3-(buta-1,3-dien-1-yl)azetidin-2-one analogues of combretastatin A-4 (CA-4) were designed and synthesised as colchicine-binding site inhibitors (CBSI) in which the ethylene bridge of CA-4 was replaced with a β-lactam (2-azetidinone) scaffold. These compounds, together with related prodrugs, were evaluated for their antiproliferative activity, cell cycle effects and ability to inhibit tubulin assembly. The compounds demonstrated significant in vitro antiproliferative activities in MCF-7 breast cancer cells, particularly for compounds 9h, 9q, 9r, 10p, 10r and 11h, with IC50 values in the range 10–33 nM. These compounds were also potent in the triple-negative breast cancer (TBNC) cell line MDA-MB-231, with IC50 values in the range 23–33 nM, and were comparable with the activity of CA-4. The compounds inhibited the polymerisation of tubulin in vitro, with significant reduction in tubulin polymerization, and were shown to interact at the colchicine-binding site on tubulin. Flow cytometry demonstrated that compound 9q arrested MCF-7 cells in the G2/M phase and resulted in cellular apoptosis. The antimitotic properties of 9q in MCF-7 human breast cancer cells were also evaluated, and the effect on the organization of microtubules in the cells after treatment with compound 9q was observed using confocal microscopy. The immunofluorescence results confirm that β-lactam 9q is targeting tubulin and resulted in mitotic catastrophe in MCF-7 cells. In silico molecular docking supports the hypothesis that the compounds interact with the colchicine-binding domain of tubulin. Compound 9q is a novel potent microtubule-destabilising agent with potential as a promising lead compound for the development of new antitumour agents.
Numerical Simulations of Supernovae Type Ia: The Early X-ray Emission

An insight of the origin of Type Ia supernovae (SN Ia) could be provided by the study of the interaction of the SN blast wave with the circumstellar medium, shaped by mass outflows from the progenitor binary. Based on the lack of thermal X-ray emission at the early phase of the SN Ia, strict upper limits have been placed on the ambient medium density around the explosion center. In this study, we perform numerical hydro-dynamical simulations of the interaction of the SN ejecta with several circumstellar structures formed by possible mass outflows from the progenitor system and we estimate the expected numerical X-ray luminosity. We considered two kinds of circumstellar structures: a) A circumstellar medium formed by the donor star's stellar wind, in a symbiotic binary progenitor system; b) A circumstellar medium shaped by consecutive novae outbursts in a symbiotic recurrent novae progenitor system. We used SPEX in order to construct new cooling curves and we applied specific SN Ia explosion models in our hydro-code. We verify the strict X-ray upper limits on the mass-loss rate of the donor star's stellar wind, in the symbiotic binary progenitor system. However, we propose that, according to our hydrodynamical simulations, a circumstellar medium formed in a symbiotic recurrent novae progenitor system could possibly explain the lack of thermal X-rays at the early phase of SN Ia. Numerical Simulations of Supernovae Type Ia: The Early X-ray
Multi-agent scheduling in a no-wait flow shop system to maximize the weighted number of just-in-time jobs

ABSTRACT This article studies a multi-agent scheduling problem on a set of m machines in a no-wait flow shop system, where each agent's objective function is to maximize its own weighted number of just-in-time jobs. Two variants of the problem are investigated. One is the constrained optimization problem and the other is the Pareto optimization problem. When the number of agents is arbitrary, both problems are proved to be strongly -hard. When the number of agents is fixed, pseudo-polynomial time algorithms are first designed to solve them, respectively, then an -approximation algorithm is provided for the former problem, and an -approximate Pareto-optimal frontier is constructed for the latter problem.
Receding horizon observer for linear time-varying systems

In this paper, we present a receding horizon observer for linear time-varying systems. Our main contribution is that known deterministic input has been fully dealt with. This poses considerable challenges for recursive formulation of the filter. The suggested observer can be used in closed-loop feedback control systems. The existing finite memory filters lack this ability. First- and second-order statistical convergence analysis carried out in this paper provide an insight into the stochastic behaviour of the observer. Some examples demonstrate the utility of the proposed filter.
The Use of Mathematical Module Based on Constructivism Approach as Media to Implant the Concept of Algebra Operation

Mathematical learning to implant the concept of algebra operation using constructivism approach is very important. Students should be actively involved in the process of building their understanding, so meaningful learning experiences can be to gained. This research was an experimental research involving 91 students of grade 8. This research applied constructivism-based mathematics module used by the students during studying the concept of algebra operation. The result showed that the use of constructivism based mathematics module was very effective in improving students' mathematical understanding on algebra operation material. This result was obtained by performing the initial test (pre-test) before the use of modules and final test (post-test) after the use of module. Addition, the result of observation conducted during the learning activities showed that in the use of modules in learning mathematics, students with high academic ability tended to be more active in the discussion process.
Effect of extrusion process parameters on pellet crumbliness in fish feed production

The article presents the results of studying the pellets crumbliness index of a pilot batch of extruded compound feed for pike-perch. The regimes of extruded pellets fish compound feed production with minimal crumbling were defined using a mathematical model. A 3-factorial central composite design was implemented to obtain a mathematical model of the process of extrudate resulting in the second-degree polynomial. The process influencing factors include the feed mixture moisture W (%), extrusion temperature T (°C) and steam pressure P (MPa). Experimental studies were conducted according to the experimental plan. The experimental data obtained were entered into the planning matrix. Experimental data was processed in a program prepared in Microsoft Excel. As a result, an adequate second-order mathematical model describing the dependence of the crumbliness index on the feed mixture moisture before extrusion, extrusion temperature and steam pressure was obtained. The mathematical model adequacy was tested based on Fisher's variance ratio. The Fisher criterion is an important statistical tool for verifying the adequacy of the model and analyzing the variance. The analysis of the obtained model and its graphical interpretation are presented. A good extrusion process mathematical model was developed. The fundamental principles of feed mixture processing on a single-screw extruder and the choice of its rational parameters ensure the production of extruded compound feed pellets for pike-perch with minimal crumbling were studied. A minimal crumbling is provided at the following values of the factors - feed mixture moisture before extrusion is 32%, extrusion temperature is 132 °C, and pressure is 0.4 MPa. In the selected levels of factors, the calculated value of extruded pellets crumbling was 1.02%.
THE HISTOPATHOLOGICAL CHANGES OF PLACENTA IN HYPERTENSIVE DISORDERS OF PREGNANCY AND THEIR CORRELATION WITH FETAL OUTCOME: A CROSS-SECTIONAL STUDY

Objectives: The objective of this study was to evaluate the histopathology and establish the correlation between placental changes in hypertensive disorders of pregnancy and fetal outcome. Methods: A cross-sectional study included 100 pregnant women with singletons admitted to the labor room with gestational ages >30 weeks and 35 weeks with hypertensive disorders of pregnancy between December 2021 and November 2022, admitted to the Department of Obstetrics and Gynecology, Sardar Patel Medical College, Bikaner. Shape of placenta, weight in grams, size, diameter in centimeters, and deposition were examined. Fetomaternal outcome was also noted. Results: Eighty percent (80) were in the age group of 21–30 years, with a mean age of 25.01±4.56 (range: 18–44 years). Only 35% of females were booked, and 63% of cases belonged to G1. Maximum cases were of pregnancy-induced hypertension (42%), followed by eclampsia (36%) and pre-eclampsia (16%), and the minimum case belonged to HELLP (1%). Although cases of placental infarction were higher in neonatal intensive care unit (NICU) admitted cases as compared to non-admitted cases (61.19% vs. 45.45%, respectively), calcification was higher in NICU-admitting cases as compared to non-admitting cases (95.52% vs. 84 vs. 5%, respectively). Syncytial knots were 94.03% vs. 81.82%, respectively, and grade fibrosis was 44.78% vs. 27.27%. Fibrinoid necrosis (71.64% vs. 54.55%) and leukocytic infiltration (68.66% vs. 63.64%). Statistically, no significant difference was observed in all parameters. Conclusion: Placental morphology and histopathology are affected in hypertensive pregnancies, which might be the reason for placental insufficiency in these cases.