Miracle-dz/UniFAR-FTUs huggingface dataset:
Do somatic USP8, USP48 and BRAF mutations differ in their genotype-phenotype correlation in Asian Indian patients with Cushing’s disease?

Purpose To estimate the prevalence of USP8, USP48 and BRAF mutations in patients with Cushing’s disease (CD) from the Indian subcontinent, and determine their genotype-phenotype correlation. Methods We prospectively recruited 46 patients with CD who underwent surgery between September 2015 and July 2019 at our institute. Fresh frozen tumour tissue was obtained in all patients. Using Sanger sequencing, the presence of somatic USP8 mutations was documented and the frequency of USP48 and BRAF mutations in USP8 wild-type corticotroph adenomas was determined. Clinical, hormonal and surgical data were then compared between USP8-, USP48- and BRAF-variant carriers and patients with wild-type tumours. Results Signature USP8 mutations were detected in 17 (37%) patients. Of the 29 USP8 wild-type adenomas, 4 (13.8%) harboured USP48 mutations, one of them being a splice-site mutation that has previously not been described. BRAF mutations were not found in any of the 29 patients. Corticotroph adenomas with USP8 mutations had a higher incidence of Crooke’s hyaline change than wild-type tumours (70.6% vs. 37.9%, p = 0.032). Adenomas with USP48 mutations had a higher rate of cavernous sinus invasion than their wild-type counterparts (50% vs. 4%, p = 0.042). No other significant phenotypic difference could be established between mutant and wild-type tumours. Conclusions The prevalence of USP8 mutations in our series of patients with CD was 37%. The prevalence of USP48 mutations in USP8 wild-type adenomas was 13.8%, including a novel splice-site mutation. BRAF mutations were not found in any USP8 wild-type tumour. USP8-mutants showed significantly more Crooke’s hyaline change and USP48-mutants were more likely to demonstrate cavernous sinus invasion.
Genetic Diversity of Indigenous Chicken (Gallus Gallus domesticus) from Ecozones of Egypt and Kingdom of Saudi Arabia

Genetic diversity of two chicken ecotypes from Ismailia-Egypt (ISM) and Taif-Saudi Arabia (TA) was evaluated using 39 microsatellites. DNA was extracted from blood of 25 chickens/ecotype. The number of alleles was 157 and 138, the number of alleles/locus averaged 4.2±2.2 and 3.6±1.6, and the highest number of private alleles was 9 and 5 for ISM and TA, respectively. Percentage of shared alleles between the two ecotypes was 45%. This panel of markers is reasonably informative as the mean polymorphic information content for ISM and TA was 0.47±0.21, and 0.41±0.2. Similar average of observed heterozygosity was attained for both ecotypes. Conversely, averages of expected heterozygosity differed between two ecotypes, 0.52±0.23 vs. 0.45±0.21 for ISM and TA. 8 and 12 loci have significantly deviated from HWE of ISM and TA. Estimate of genetic distance was 0.2 and FST index was 0.29. Results showed only 6% of genetic diversity is shared between these two ecotypes.
An Analysis of Terrorist Group Formation, 1860—1969

ABSTRACT A number of new and exciting datasets on terrorist groups have been created in recent years. However, most data have limited temporal coverage. In this article, we explore a dataset of historical terrorist groups formed between 1860 and 1969 to determine which insights from the terrorism literature are generalizable over time. A cursory look into the dataset reveals several trends that have been overlooked by both the qualitative historical terrorism literature and the quantitative contemporary terrorism literature. We also perform an econometric analysis of terrorist group formation to test hypotheses derived from the extant research. Our results show limited support for existing hypotheses, although civil society participation appears consistently associated with terrorist group formation.
Clinical and hemodynamic assessment of patient receiving prosthetic mitral valve replacement

Cite this article: Talukdar Mrinmoy, Konwar Ranjumoni, Deka Arun. Clinical and hemodynamic assessment of patient receiving prosthetic mitral valve replacement. Int J Health Res Medico Leg Prae 2021 Jan-Jun;7(1):77-83. Doi: 10.31741/ ijhrmlp.v7. i1.2021. 13. Background and aims: Mitral valve replacement by mechanical or bioprosthetic valves revolutionized the care of patients with severe mitral valve disease. Mitral valve is commonly affected by Rheumatic heart disease, leading to the development of mitral stenosis and regurgitation requiring prosthetic replacement. The clinical and hemodynamic assessment of patients undergoing mitral valve replacement is substantial in measuring the extent of morbidity. The present study assesses patients’ pre and postoperative hemodynamic parameters having mitral valvular diseases requiring prosthetic replacement. Materials and methods: The study included 45 selected cases of the mitral valvular lesion that underwent prosthetic replacement of mitral valve admitted in the cardiothoracic surgery department at a tertiary care centre. A detailed history of each patient was taken, and subsequent management and follow up was done. The hemodynamic assessments of the patients were performed by invasive pressure measurement and by echocardiographic measurement during preoperative, post-operative and follow-up period. Statistical analysis was performed with the Quick Calcs Online calculator (Graph Pad Software). Continuous variables are expressed as mean and standard deviation after checking for normality of distribution. Differences between baseline and follow-up were analyzed using paired t-test. A p-value of <0.05 was considered statistically significant. Results: A total of 45 patients of age ranging from 14 years to 65 years undergoing mitral valve replacement were included in the study. Substantial decrease in the mean pulmonary artery (PA) and left atrium (LA) pressure were observed after valve replacement compared to pre valve replacement in all the three valvular lesion groups, i.e., mitral stenosis, mitral regurgitation and combined valvular lesion groups with p-value <0.0001. The subsequent decrease in left atrial diameter post-operative six months was also noted in all the groups. No significant postoperative improvement in ejection fraction was noticed in the mitral stenosis and mitral regurgitation group. Considerable progress in mean transmitral gradient after valve replacement is seen among all the groups (pvalue <0.0001) with a substantial decrease at six-month post-operative compared to the preoperative trans-mitral gradient. Conclusion: Steady, significant improvement in patients with different valvular abnormalities is noticed after prosthetic replacement of the mitral valve. Prosthetic replacement of mitral valve provides satisfying hemodynamic improvement. Keyword: Rheumatic heart disease; mitral valve; mitral stenosis; mitral regurgitation; hemodynamics; echo-cardiography. Talukdar Mrinmoy, Konwar Ranjumoni, Deka Arun
Removal of chromium from contaminated liquid effluents using natural brushite obtained from bovine bone

aInstituto Politécnico Nacional-UPIIG. Av. Mineral de Valenciana 200, Col. Fraccionamiento Industrial Puerto Interior, C.P. 36275 Silao de la Victoria, Gto, Mexico, Tel. +52 1 55 5729 6000 Ext. 81416; emails: rohernandezs@ipn.mx (R.H. Soto), jahmuam@gmail.com (J.A.H. Maldonado), fatg1991@gmail.com (F.A.T. García) bDepartamento de Ingeniería en Minas, Metalurgia y Geología, División de Ingenierías, Universidad de Guanajuato, Ex Hacienda de San Matías s/n. Fracc. San Javier, C.P. 36025, Guanajuato, Gto, Mexico, Tel. +52 473 732 22 91; email: merce@ugto.mx
A Configurational Exploration of How Female and Male CEOs Influence Their Compensation

The issues of excessive CEO compensation and gender pay gaps garner much attention from management scholars and the general public. In this study, we integrate these topics and explore the complex interdependent nature of how CEOs influence directors’ evaluative perceptions about appropriate levels of CEO compensation and whether female and male CEOs do so in different ways. Drawing from role congruity theory and previous research on executive compensation, we use a configurational approach to identify how CEOs achieve high levels of compensation through different combinations of influence arising from their power, origin, tenure, similarities with evaluators, and organizational conditions. Using fuzzy set qualitative comparative analysis with a matched pair sample of female and male CEOs from 2010 to 2016, we find there are multiple configurations of influence conditions by which female and male CEOs achieve high compensation. Our inductive analysis, unpacking how these configurations differ between female and male CEOs, shows four distinct influence mechanisms: leveraging power and role empathy, trailblazer responsibility, leveraging power and similarity, and leveraging role empathy. These mechanisms highlight the ways influence conditions complement or mutually reinforce one another in different ways for female and male CEOs. Implications for theory and research about the unique challenges female executives face in achieving equitable treatment in the workplace are also discussed.
Numerical Investigations of Two-Phase Flow on a Stepped Spillway under Various Conditions

In this study, two-phase flow over a three-dimensional stepped spillway was numerically investigated using a finite volume code in ansys-Fluent commercial software. The numerical results were validated against experimental data. Then, the effects of several parameters were evaluated on the structure of the flow over the concerned spillway. Based on the natural roughness, several roughness heights of 0.0001, 0.0005, and 0.001 m were considered on the spillway surface to investigate the flow structure. In the next step, several surfaces with different contact angles, including 80, 120, and 160°, were used. Finally, a passive control method, including simultaneous blowing and suction with different configurations, was applied to the steps of the spillway. The results revealed that a change in the surface roughness or contact angle and applying the control method could change the flow regime from skipping to nappe. Also, variations in the speed of falling water and energy loss were attributed to changes in the surface roughness and contact angle and implementation of the proposed control method.
The effect of international subsidiaries on voluntary disclosure - evidence from natural disasters

This paper documents that managers of multinational companies adjust voluntary disclosure after significant events at international subsidiaries. We show an increase in the likelihood and frequency of management forecasts following natural disasters in regions where companies operate subsidiaries. The exogenous and staggered nature of natural disasters as well as our research design choices substantially raise the hurdle for alternative explanations of our result. Further analyses suggest that the effect is particularly strong for companies that rely on equity financing. Our paper contributes to the nascent literature on transmission effects within international business groups.
Do People Like Mandatory Rules? The Choice Between Disclosures, Defaults, and Mandatory Rules in Supplier‐Customer Relationships

In recent years, numerous empirical studies have examined the prevailing attitudes toward nudges, but hardly any have examined the prevailing attitudes toward mandatory rules. To fill this gap, this article describes five studies (N=3,103)—mostly preregistered studies conducted with representative samples of the U.S. population—which tested people’s attitudes toward mandatory rules in contractual settings. We found that in supplier-customer relationships, people tend to rate mandatory rules as more desirable than disclosure duties and default rules. People’s judgments in this regard depend on the relative effectiveness of the various types of rules in protecting customer’s interests and their expected impact on the price; but there is considerable support for mandatory rules even if they are only slightly or moderately more effective than the alternatives, and even when they entail some price increase. People tend to believe that mandatory rules in this sphere enhance customers’ freedom of contract—which may explain why these judgments are not correlated with people’s ideological inclinations (liberal or conservative).
Environmental Radioactivity evaluation and its health-related effects using gamma spectrometry in Delanta-Dawunt, Wollo District, Ethiopia

Background & Methodology : The specific activity concentration of naturally occurring radionuclides 226Ra, 232Th, 40K and their health related effects were determined in different environmental samples(gemstones) collected from Delanta-Dawunt. Which is one of the mining place in Ethiopia to extract mainly opals (gemstones). Sample collection and the gamma spectroscopic analysis followed the recommended international procedures for such type of research. Gamma-ray spectrometry was applied using HPGe gamma-ray detector and PC-based MCA. The Purpose of this research: to determine the activity concentrations of the radionuclides U/Th series and K of gemstones(opals), to determine life time cancer risk of radionuclide in the environment , to assess the hazard and risk to the public associated with these dose values , to conduct the geochemical studies by quantifying the levels of trace gemstones as well as the physical parameters in soil samples within and around it, and To determine the radiation doses from these activity concentrations and compare with international recommended dose limits. Results: The results of the activity concentration on our research work showed significant variations from 11.97 ± 2.46 to 62.44 ± 14.99 Bq kg-1 for 226Ra, 25.69 ± 3.69 to 137.84 ± 13.23 Bq kg-1 for 232Th and 184.84 ± 3.59 to 969.56 ±18.16 Bq kg-1 for 40K. The mean radioactivity concentration of 226Ra, 232Th, and 40K was found to be around 29.84 ± 6.53, 68.44 ± 18.94, 390.87 ± 6.09 Bk kg-1 respectively. Conculsion: The mean values of Radium equivalent activity (Raeq), absorbed dose, annual effective dose equivalent, external and internal radiation hazard (Hex and Hin) index ,and activity utilization index is 151.68±19.46 Bq kg-1, 72.19 ± 8.48 nGy h-1, 0.07 ± 0.01mSv y-1,0.43, 0.51, 0.57 ± 0.08 and 0.29 ± 0.03 respectively. The specific activity of 232Th is higher than the world mean value and 40K is the same as the world mean value. The radiation hazard indices, ELCR values found in this study are lower than the world mean values. However, the absorbed dose is higher than the world means value. This is due to the reason of high thorium concentration existence and opal mining is highly explored on such study areas.
CHARACTERISTIC AND HISTOPATHOLOGICAL FEATURES OF PATIENTS WITH PERFORATED PEPTIC ULCER WHO UNDERWENT OPEN SURGERY THERAPY AT DR.SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA

Background: Perforated peptic ulcer is a form of complications from peptic ulcer and one of the most common emergency conditions in medicine. Objective: To describe the characteristic and histopathological features of patients with perforated peptic ulcer who underwent open surgery therapy in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Materials and Methods: This study was a descriptive study by observing patients’ data from medical records (secondary data) at Medical Record Center of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2016. Data obtained were analyzed descriptively. Results: Forty-six patients were identified (34 male, 12 female), most of them were between 56-65 years old for male and ≥66 years old for female. Majority of the subjects had a history of herbal medicine consumption (54%) as risk factors for developing perforated peptic ulcer and the most frequent comorbid diseases were diabetes and hypertension. The histopathological features found mostly were inflammation (100%), necrosis (44%), fibrosis (36%), granulation (17%) and positive Helicobacter pylori (6%). Conclusion: Majority of the subjects were male, mostly between 56-65 years old for male and ≥66 years old for female. The histopathological features showed that all subjects had inflammations.
Impacts of Electricity Outages in Urban Households in Developing Countries: A Case of Accra, Ghana

Many developing countries in Africa face a “double tragedy” when it comes to electrification. Electricity access rates are low, while those who have access to electricity face frequent outages. There are ongoing efforts aimed at increasing access to electricity on the continent. However, the need to improve the reliability of electricity supply receives limited attention. Unreliable electricity impacts users by limiting electricity utilization and the benefits that should accrue from having an electricity connection. Using data from 496 household survey questionnaires, this study examines the impacts of electricity outages in urban households in Accra, Ghana. The study applies correlation and regression analyses to identify which household characteristics are associated with or predict households reporting outage impacts. Outages were found to impact household safety/security, access to food, and access to social services and were found to cause appliance damage as well. Factors that are significantly correlated with reporting certain outage impacts include respondent’s annual income and employment status, frequency of electricity outages, and household size. Significant predictors of reporting outage impacts are socioeconomic disadvantage, high exposure to outages, and living in a large family setting. The study’s findings underscore the need for interventions to eliminate, or at least minimize, electricity supply interruptions in developing countries if sustainable social and economic development is to be achieved.
A Comparative Survey of Coding, Multiplexing, and Equalization Techniques Used in Coherent Optical Fiber Communications

As the world advances into 5G networks, significant scientific research accomplishments are being conducted for a communication system that could further enhance the current limit of data transmission capacity. Currently, the communication systems with the highest data rate are optical fiber systems. Due to the recent advancement of coherent optical fiber communications by exploiting time, wavelength, phase, amplitude, polarization, and space, optical engineering can break the petabit barrier data rate. Thus, coherent optical fiber communications is a hot topic due to its very high data rate that could be applied or a requirement in 5G and big data analytics. This paper focuses on a comparative survey of the current applied fundamental techniques in fiber communication channels. These fundamental techniques that could be further studied and exploited to increase the bandwidth performance, decrease the error rate and energy consumption are coding, multiplexing, and equalization. At the end of this paper, a comparative result is discussed to explain the difference among the current techniques in the literature for the optical engineering community to improve collective coding, multiplexing, and equalization in coherent fiber systems.
THE RELATIONSHIP OF SOCIO- ECONOMIC STATUS AND THE OCCURRENCE INJURY OF DIABETES MELLITUS PATIENTS

Socio-economic status includes a person's lack of education and income which can affect a person's health status. The purpose of this study was to determine whether there is a relationship between socioeconomic status and the incidence of injury in people with Diabetes Mellitus. The method used is a correlation analytic design, with a cross-sectional approach with a sample of 120 respondents. The instrument used was a questionnaire. The data were processed using the Spearman statistical test. The results showed that there was a significant relationship between socioeconomic status and the incidence of injury (p-value = 0.001; r = -0.313). Results of multivariate analysis in research using linear regression that shows that the R result is 0.343. The socioeconomic status regression coefficient on the incidence of injury was 0.185 while the regression coefficient for self-care activities on the incidence of injury was 0.133. A socio-economic status that includes education and income influences a person to carry out self-care management to prevent complications of Diabetes Mellitus, namely Diabetic ulcer. Keywords: Diabetes Mellitus; Incident Of Injury; Socio-Economic Status
Peculiarities Of Existential Fulfillment And Coping Strategies In Post-Stroke Patients

Diseases in the circulatory system of the brain are not only a medical but also a social problem. Social support is one of the factors for successful rehabilitation and prevention of post-stroke depression (PSD). The purpose of the study is to identify the peculiarities of coping strategies and existential fulfillment in post-stroke patients with speech disorders. The study involved 50 patients with the first occurrence of ischemic stroke (25 patients with both motor and speech disorders, 25 patients with motor disorders without any speech defects). Were applied the Rankin Scale (mRs), the Barthel Index (BI), Existence Scale Questionnaire (A. Langle and C. Orgler), D. Amirkhan's "Coping Strategy Indicator" (adapted by N.A. Sirota and V.M. Yaltonsky), the non-parametric Mann-Whitney U test. The analysis of the results of the coping-strategy examination showed significant differences between groups on the strategy of "seeking social support" (U = 82,000; at p = 0.074), on the Self-Transcendence subscale (U = 65,000; at p = 0.015) and the Freedom subscale (U = 54,500; at p=0.004). In conclusion, the lack of ability to express their emotions and desires through speech, as well as to interact with people in patients with speech disorders leads to emotional flattening and poor interaction with the world and people, refusal to seek help and social support from family, friends and other important people.
Effects of Application of Chlorpyrifos Ethyl and Rose Water on Rat Pancreas

This study was conducted to detect preventive effects of rose water against toxicological effects of chlorpyrifos-ethyl. Group I was control group, group II was chlorpyrifos-ethyl (CPE) group (0.3 mg/kg/day) , group III was water solution of rose extract (WR) group (100 mg/kg/day) while group IV was water solution of rose extract + chlorpyrifos-ethyl group (WR+CPE). The rats were sacrificed after fifteen days of experiment to collect blood samples. The results showed that comparing to the CPE group, there was a significant (p<0.001) decrease in the malondialdehyde (MDA) and total oxidant capacity (TOC) levels and a significant (p<0.001) increase in the total antioxidant capacity (TAC) and insulin levels in the CPE+GS group. Between the control and WR groups, insulin, WBC, catalase (CAT), lipase and amylase levels were significantly (p<0.001) higher, while TOC and OSI levels were significantly (p<0.001) lower in the WR group. The highest OSI levels were determined in the CPE group followed by CPE+RW (1.02 µmol H 2 O 2 equ./L), control (0.93 µmol H 2 O 2 equ./L) and RW (0.87 µmol H 2 O 2 equ./L) groups. In conclusion, it can be said that WR showed positive effects on the enzymes of pancreas and hematological parameters in rats, and it reduced in toxic effects of CPE.