Miracle-dz/UniFAR-FTUs huggingface dataset:
Anatomical variations in shape of suprascapular notch of scapula

Objective: The present study is a simple method to classify the shapes of the suprascapular notch on the basis of gross examination. Methods: 250 dried scapulae were examined for variations of suprascapular notch. Results: Three types of suprascapular notches are described. 55 had u shaped 45 had v shaped and 55 had J shaped. Absence of notch was also noted. Conclusion: This study will help to correlate suprascapular nerve entrapment with a specific type of suprascapular notch.
Nuclear Receptors and Breast Cancer

Until recently, the study of nuclear receptor (NR) function in breast cancer biology has been largely limited to estrogen and progesterone receptors. The development of reliable gene expression arrays, real-time quantitative RT-PCR, and immunohistochemical techniques for studying NR superfamily members in primary human breast cancers has now revealed the presence and potential importance of several additional NRs in the biology of breast cancer. These include receptors for steroid hormones (including androgens and corticosteroids), fat-soluble vitamins A and D, fatty acids, and xenobiotic lipids derived from diet. It is now clear that after NR activation, both genomic and nongenomic NR pathways can coordinately activate growth factor signaling pathways. Advances in our understanding of both NR functional networks and epithelial cell growth factor signaling pathways have revealed a frequent interplay between NR and epithelial cell growth factor family signaling that is clinically relevant to breast cancer. Understanding how growth factor receptors and their downstream kinases are activated by NRs (and vice-versa) is a central goal for maximizing treatment opportunities in breast cancer. In addition to the estrogen receptor, it is predicted that modulating the activity of other NRs will soon provide novel prevention and treatment approaches for breast cancer patients. (Molecular Endocrinology 22: 2215–2228, 2008)
KSHV suppresses PDLIM2 for tumorigenesis

KSHV is the most common cause of malignancies among AIDS patients. However, how KSHV induces tumorigenesis remains largely unknown. Here, we demonstrate that one important mechanism underlying the tumorigenesis of KSHV is through transcriptional repression of the tumor suppressor gene PDZ-LIM domain-containing protein 2 (PDLIM2). PDLIM2 expression is repressed in KSHV-transformed human umbilical vascular endothelial cells (HUVECs) as well as in KSHV-associated cancer cell lines and primary tumors. Importantly, PDLIM2 repression is essential for KSHV-induced persistent activation of nuclear factor kappaB (NF-B) and signal transducer and activator of transcription 3 (STAT3) and subsequent tumorigenesis and tumor maintenance. Our mechanistic studies indicate that PDLIM2 repression by KSHV involves DNA methylation. Notably, the epigenetic repression of PDLIM2 can be reversed by 5-aza-2deoxycytidine (5-aza-dC) and vitamin D to suppress KSHV-associated cancer cell growth. These studies not only improve our understanding of KSHV pathogenesis but also provide immediate therapeutic strategies for KSHV-mediated cancers, particularly those associated with AIDS.
The effects of online shopping on the market for retail real estate

In the period following the start of the economic crisis retail vacancy has steadily increased in many countries around the world. A frequently mentioned cause of the increase in retail vacancy is the growing popularity of online shopping. In various scientific publications, scholars have addressed the possible future implications of online shopping. In this research an attempt is made to empirically examine the effects of online shopping on the demand for retail real estate. This is done, using a correlation analysis and a multiple regression analysis. The results show that the increase in online expenditures, between 2011 and 2016, is significantly associated with the decrease in the demand for retail real estate. Therefore, online shopping should be considered as a substitute for traditional in-store shopping. These insights are used to determine the broad implications for retail policy.
The Influence of Reasons to Choose Different Applications on Chances of Getting Sleeping Partners Among Men Who Have Sex with Men (MSM) Online App Users, Bangkok, Thailand

Objectives: To explore the reasons that motivate MSM choosing the application and possibility of finding sex partners among MSM online app users and compared between two groups of participants regarding to HIV-status. Methodology: A crosssectional study was conducted among MSM aged 15 and older who live in Bangkok, Thailand. The data collection was conducted during Jun-Dec 2018. The target population who are HIV-infected were approached on the day of visiting at the research clinic while the HIV-noninfected were approached from two venues; at the reproductive health clinic and words of mouth. Of those who are not available to do a questionnaire at the clinic but willing to participate into the study, the questionnaires were distributed via email after the verbal consent. A structured questionnaire was test using Cronbach’s alpha (0.77). A descriptive analysis and logistic regression were used to analyze the data. Results: The total of 201 were recruited into the study, there are 71 people who are HIV-infected, and 130 people are HIV-noninfected. The analysis was included only whom reported using online media as a platform for seeking sex partners which totally accounted for 130 including 57 of infected and 73 of noninfected. The number of HIV-negative participants had reported getting sex partners from using applications higher than HIV-positive participants approximately thirty percent.The reasons either with or without intention to seek for sex partners that convince them to choose different applications, they eventually have possibility to have chance of getting sex partners. (HIV-infected VS. HIV-non infected: p-value < 0.01** VS. p-value <0.01**). Conclusions: The results yield from two groups of participants that regarding to any reasons of choosing application they have possibility to find sex partners from online applications. Therefore, preventive strategies should be concern on how to promote HIV prevention from this venue. Keywords— Men Who have Sex with Men (MSM) Online app users, Risky behaviors, Thailand.
The Integrative Model of International Innovation Network and Performance

Research in social network has demonstrated that firms in changing environment will benefit from innovation network. However, the lack of consensus on what factors and how these factors impact the performance impedes the further research in this area. In this paper, the concept of international innovation network and its performance are clarified. Then, based on reviews of the social network and knowledge management literature, especially along with the results of previous empirical studies, we propose an integrative model in which the performance of focal firm within international innovation network is impacted by network structure (network range and density), network relationship (tie strength, duration, and norm distance), and network position (centrality). We also come up with some efforts that the firm can make in order to improve its performance. In the end, the future research following this study is discussed.
Fresh and Hardened Properties of Self Compacting Concrete Made With Coal Bottom Ash

The current investigation examine the fresh, mechanical and durability properties of SelfCompacting Concrete (SCC) made with different proportions of (0%, 25%, 50%, 75% and 100%) of Coarse Recycled Aggregate (RCA) in place of Natural Coarse Aggregates (NCA) along the optimum replacement (10%) of Natural Fine Aggregates (NFA) with Coal Bottom Ash (CBA). The study inferences that the incorporation of RCA up to 50% along with 10% CBA have increased the performance of the SCC mixes in terms of mechanical as well as durability properties. It has been found that the addition of Metakaolin (MK) has improved the aforementioned properties significantly at all ages of curing and a better performance has been achieved even at full replacement (100%) of NCA with RCA.
High Affinity Receptor for IgE Chemotactic Protein-1 Stimulated by the Synthesis and Secretion of Monocyte

In prior studies aggregation of the high afﬁnity receptors for IgE, Fc (cid:1) RI, on a rat mast cell line, RBL-2H3, stimulated transcription of the gene for monocyte chemotactic protein-1 (MCP-1) and secretion of the protein. Unexpectedly, those delayed events appeared much less constrained by kinetic proofreading than had been documented for other receptor-initiated responses. The results of the present experiments are consistent with the proposal that the biosynthesis and secretion of MCP-1 result from a soluble messenger formed in the reaction cascades initiated by the receptor, and that Ca 2 (cid:2) could serve as that messenger. Interestingly, whereas receptor-mediated signals were required for transcription of the gene for MCP-1 and secretion of the chemokine, such signals were not required for the intervening step of translation of its mRNA. The Journal of Immunology, 2003, 170: 2680–2687. of line delayed suspended in buffer A at a cell density of 1 (cid:4) 10 6 cells/ml. After stimulation at 37°C with varying doses of DNP or NP Ags, the cells were lysed with Triton X-100-containing 3 (cid:4) solubilization buffer, anti-mouse IgE was added, and the immunoprecipitated Fc (cid:1) RI:IgE complexes were analyzed for phosphotyrosine as previously described (10). were repeated at least three times to test for repro- ducibility. However, although we attempted to handle the cells in the same way, the absolute picograms of MCP-1 varied on a day-to-day basis. For this reason we present absolute data only from individual experiments and relative (normalized) data where the results of several experiments were pooled. The of as previously described (12), using p -nitrophenyl N -acetyl- (cid:4) - D -glucosaminide as a substrate.
Identification and Characterization of a Golgi-Localized UDP-Xylose Transporter Family from ArabidopsisOPEN

Berit Ebert,a,b,c,1 Carsten Rautengarten,a,c,1 Xiaoyuan Guo,b Guangyan Xiong,d Solomon Stonebloom,a Andreia M. Smith-Moritz,a Thomas Herter,a Leanne Jade G. Chan,a Paul D. Adams,a,e Christopher J. Petzold,a Markus Pauly,d William G.T. Willats,b Joshua L. Heazlewood,a,c and Henrik Vibe Schellera,d,2 a Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 bDepartment of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, C 1871 Copenhagen, Denmark c ARC Centre of Excellence in Plant Cell Walls, School of BioSciences, The University of Melbourne, Victoria 3010, Australia d Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 eDepartment of Bioengineering, University of California, Berkeley, California 94720
Measurement of branching fractions and rate asymmetries in the rare decays

In a sample of 471 (cid:3) 10 6 B (cid:1) B events collected with the BABAR detector at the PEP-II e þ e (cid:2) collider we study the rare decays B ! K ð(cid:1)Þ ‘ þ ‘ (cid:2) , where ‘ þ ‘ (cid:2) is either e þ e (cid:2) or (cid:1) þ (cid:1) (cid:2) . We report results on partial branching fractions and isospin asymmetries in seven bins of dilepton mass-squared. We further present CP and lepton-ﬂavor asymmetries for dilepton masses below and above the J= c resonance. We ﬁnd no evidence for CP or lepton-ﬂavor violation. The partial branching fractions and isospin asymmetries are consistent with the Standard Model predictions and with results from other experiments.
National Youths Service Corps and Multiculturalism: The Epicenter for National Integration in Nigeria

The heterogeneous nature of Nigerian society has been a contentious issue n the frameworks of national leadership since independence. Multiculturalism is a uniting or divisive factor for Nigeria; it is an instrument of nationhood, culminating in a civil war, agitations for state creation, sovereign national conference, rotational presidency, and zoning system in recent times, ethnic and religious insurgency as well as terrorist violence. National integration is far-fetched and a quest by successive administrations and non-state actors who are stakeholders in the Nigerian project. The context of external influences such as migrants, foreign visitors and unwanted aliens and their activities is un accountable. This paper examines the evolution of multiculturalism in the challenge of national unity, with particular attention on national youth service corps scheme in Nigeria’s 21 century. The grave dangers of insecurity posed by unchecked aliens and non-patriotic aliens flock into the nation through the countries porous border. A descriptive-analytical approach is applied, while the data are basically collected from texts and academic journals. The Nigerian state requires an overhaul of its security within and outside its borders for cursory look at immigration system.
Episodic memories of wilderness experiences foster sustainable leadership style transformation

Purpose – This research evaluates (1) work situations prompting participants to recall memories of a wilderness-based leadership training program, (2) the content of suchmemories, and (3) the leadership attitudes and behaviors inspired by those memories. Design/methodology/approach – A qualitative content analysis of semi-structured interviews was performedwith 36 leaders who had participated in a wilderness leadership transformation program in the past (on average six years before). Findings –The findings suggest that, at moments with emotional pressure and psychological stress, episodic memories of wilderness experiences have a positive influence on actual leadership style. Memories involved moments of solitude, a deep connection with nature, and peer-to-peer counseling. The interviewees regularly relived their emotion-ladenwilderness experiences, acquiring direction and guidance. Simultaneously, episodic memories of nature immersion promoted an enduring transformation of their leadership styles. Research limitations/implications –The findings cannot be blindly generalized as referring to all leaders. The leaders in this study are a subset of leaders who are inclined towards personal growth and leadership development. It is challenging to motivate leaders unkeen on changing to achieve better leadership. Practical implications – This study indicates that the inclusion of emotional concepts to address the root causes of learning among leaders might be the most promising way to innovate leadership development. Originality/value – The present study makes a novel contribution to relevant literature by examining leadership transformation through episodic remembrance of leaders’ experiences in nature.
The Impact of IOS Use and Interpersonal Ties on Digital Innovation: Insights from Boundary Spanning and Institutional Theories

Drawing upon the boundary spanning and institutional theories, this study investigates the influence of interorganizational systems (IOS) use and interpersonal ties between a firm and its suppliers on a firm’s digital innovation and how such effects are moderated by institutional distance between the firm and its suppliers. Based on a pilot test of 123 Chinese firms, our results find that a firm’s use of IOS significantly improves its digital innovation, while interpersonal ties between the firm and its suppliers do not significantly improve the firm’s digital innovation. Further, we find that institutional distance between the firm and its suppliers differentially moderates the influences of IOS use and interpersonal ties on digital innovation. Specifically, institutional distance negatively moderates the impact of IOS use on digital innovation yet positively moderates the impact of interpersonal ties on digital innovation. We further discuss the theoretical contributions and managerial implications of the current study
Novel MHC Class I Structures on Exosomes

Exosomes are nanometer-sized vesicles released by a number of cell types including those of the immune system, and often contain numerous immune recognition molecules including MHC molecules. We demonstrate in this study that exosomes can display a signiﬁcant proportion of their MHC class I (MHC I) content in the form of disulﬁde-linked MHC I dimers. These MHC I dimers can be detected after release from various cell lines, human monocyte-derived dendritic cells, and can also be found in human plasma. Exosome-associated dimers exhibit novel characteristics which include 1) being composed of folded MHC I, as detected by conformational-dependent Abs, and 2) dimers forming between two different MHC I alleles. We show that dimer formation is mediated through cysteine residues located in the cytoplasmic tail domains of many MHC I molecules, and is associated with a low level of glutathione in exosomes when compared with whole cell lysates. We propose these exosomal MHC I dimers as novel structures for recognition by immune receptors. The Journal of Immunology, 2009, 183: 1884–1891. xosomes are small vesicles in the size range 50–150 nm that form by the inward budding of endosomes to gener-ate multivesicular bodies (MVBs) 3 A proportion of these MVBs can fuse with the plasma membrane, releasing their internal vesicles to the extracellular environment. A wide variety of cell types has been reported to secrete exosomes, including re-ticulocytes (5), neurons (6), epithelial cells lymphocytes mast cells dendritic cells against MSDB database. The data was searched with tolerances of 0.2 Da for the precursor and fragment ions, trypsin as the cleavage enzyme, one missed cleavage, carbamidomethyl modiﬁcation of cysteines as a ﬁxed modiﬁca- tion and methionine oxidation selected as a variable modiﬁcation. The Mascot search results were accepted if a protein hit included at least one peptide with a score above the homology threshold and the MS/MS inter-pretation accounted for the major peaks in the spectrum.
Prevalence of Abnormal Papanicolaou Smear in Pregnant Women at Phramongkutklao Hospital

Objective To determine the prevalence of abnormal Papanicolaou smear in pregnant women who attended the antenatal care clinic at Phramongkutklao Hospital, the prevalence of risk factors of cervical cancer in pregnant women and the results of the organism on Papanicolaou smear with pregnancy outcome. Material and Method A prospective analysis was performed on 384 pregnant women who attended the antenatal care clinic at Phramongkutklao hospital between 1 September 2006 and 1 May 2007. Participants were recruited for Papanicolaou smear, and followed until delivery. Data collection included demographic characteristics, risk factors of cervical cancer, results of Papanicolaou smear and outcomes of pregnancy. Results From 384 cases, the prevalence of abnormal Pap smear was 38%; candida spp. 23.4%, bacterial vaginosis 14.0%, trichomonas spp. 0.2%, and low-grade squamous intraepithelial lesion (LSIL) or LSIL with HPV 0.4 %. Risk factors found in pregnant women with preinvasive lesion were husband with multiple partners and smoking. Pregnant women with preterm birth and PROM occurred in women with candida spp 21.9% and 5.9% whereas bacterial vaginosis 9.4 % and 4.4%. Conclusion Prevalence of abnormal Pap smear was 38%.
University of Southern Denmark Optical waveguides with compound multiperiodic grating nanostructures for refractive index sensing Neustock,

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DMSO_A_316187 3499..3506

1Department of Pharmaceutical Sciences, School of Pharmacy, Institute of Health, Jimma University, Jimma, Oromia, Ethiopia; 2Jimma University Laboratory of Drug Quality (JULaDQ), Jimma University, Jimma, Oromia, Ethiopia Background: Dissolution is the critical quality control parameter and used to predict an in vivo oral bioavailability, and it is used to support bio-waiver. Aim: To evaluate and compare the dissolution profile of eight brands of metformin HCL 500 mg tablets available in Jimma town, Southwest Ethiopia. Methods: The study was conducted in Jimma town, Ethiopia. Eight (seven brands and one comparator) metformin HCL 500 mg tablets were included. The dissolution study was conducted as per United States Pharmacopeia, and the dissolution profile was compared by one-way ANOVA, model-dependent and model-independent approaches. Results: All of the included tablet brands complied with single-point dissolution study specification. Statistical comparisons of the dissolution profile by one-way ANOVA revealed that all brands had similar dissolution profiles (p=0.89). All of the brands had a similarity factor (f2) >50% and the difference factor (f1) <15. The entire brands followed the Weibull curve approach (the highest coefficient of determination and lowest Akaike Information Criteria) for the release of an active pharmaceutical ingredient. Conclusion: All of the brands complied with single point dissolution study and all of them could be used interchangeably with the innovator drug. All brands followed the Weibull method for the release of the drug substance.
Investigation on response of growth and yield characters of eggplant over moistures stress and dissection of genetic parameters

Eggplant, as a hardy solanaceous crop it’s very difficult to develop superior drought tolerant hybrids due lack of gene pool. Present study was conducted in a factorial CRD design with three replication over fifty different eggplant genotypes with two drought level. The experimentation resulted highly significant differences (P ≤ 0.01) among the genotypes in different levels of drought treatment except numbers days for flower initiation. Genetic variability analysis shown observed traits had high GCV, PCV, broad sense heritability coupled with high genetic advance under moisture stress and normal moisture condition. Except, traits like plant height and total plant length as well as number of days for flowering resulted moderate PCV and GCV under both the conditions. The overall mean performance exposed that genotypes like M17, Very Green Long, IIHR-7, Solanum Indicum, IC354597-Round, Swarna Mani, IC99676-Round and Jawahar Brinjal-69 are best drought tolerance genotypes in comparison with yield.