Miracle-dz/UniFAR-FTUs huggingface dataset:
Information Acquisition Experience, Investor Sophistication, and IPO Price Pressure

We propose a simple measure of investor sophistication based on financial statement experience derived from publicly available EDGAR log data about accounting information acquisition activity. This approach allows us to provide unique empirical evidence for the existence of attention induced price pressure effects in the cross-section of initial public offerings, i.e. that pre-IPO-week attention from likely unsophisticated investors is associated with higher initial returns and subsequent, significant price depreciations. These results are robust to various measures of abnormal post-IPO returns, attention, and sophistication. The proposed direct experience-measurement is easily replicable and potentially useful for many other questions in economics.
Reproducible One-Step Fabrication of Compact MAPbl(3-x)Cl(x) Thin Films Derived from Mixed-Lead-Halide Precursors

Methylammonium lead trihalide perovskites are attracting intensive interest due to its high photovoltaic performance, low cost and one-step solution processability. Since the morphology of the perovskite thin films play the central role on the cell performance, a plethora of methods have been developed to fabricate uniform perovskite film. Herein, we demonstrate that an innovative approach by applying mixed lead salts (PbI2 + PbCl2) to facilitate reproducible fabrication of compact perovskite thin film. It is proposed that rapid reaction kinetics of PbI2 with MAI enables preformation of perovskite within the intermidiate film matrix, working as homogeneously located domains for squential growth of the PbCl2-derived perovskite. The as-prepared perovskite film exhibited a overall textured crystal morphology and superior compactness, which enables excellent light absorption and long-time preservation of photogenerated charge carriers and therefore exhibits 11% efficiency in planar-structured solar cells. The annealing testing shows the film also possesses very stable morphology upon long-time heating, indicative of the insensitivity of our new protocol to the preparation condition and also the promising thermal stability of its based solar cells. The simplicity of the one-step solution-processing and the high morphology stability of the as-prepared perovskite film endow this mixing lead salts method with feasibility of the large-scale fabrication.
Maintaining Local Wisdom Aa Nationalism Measurement

, The attitude of nationalism of the younger generation is thought to have been eroded by modernization and globalization. This will endanger the unity and integrity of the Indonesian nation. This study aims at describing the local wisdom forms held firmly by public figures to represent nationalism. This research is a descriptive qualitative study. The objects of this study are the three-winning of the novel-writing contest of Seberapa Indonesiakah Kamu? ; the novels are entitled Karena Aku Tak Buta by Redy Kuswanto, Kaki Langit Talumae by Wishnu Mahendra, and How to Love Indonesia by Buma M. Sembiring. This study's result shows that The form of local wisdom practiced by the main character in his life is to maintain and develop values, traditional arts, and traditions passed on by previous generations. The attitude of love for the country shown by the younger generation of Indonesia is affected by the pattern of education in the family, the community, and the figures' problems. The nationalism is manifested by figures in maintaining local wisdom that applies to Indonesian society. Local wisdom is passed on to the younger generation through education both within the family and in society. This local wisdom continues to strengthen and the awareness of leaders in solving problems in the surrounding environment. Local wisdom that is held firmly by figures not only affects their lives but also has a positive impact on the surrounding environment.
Construction of PX-LmGP63 Using CRISPR-Cas9 as Primary Goal for GP63 gene Knockout in Leishmania major and Leishmanization

Background: Leishmania is an intracellular protozoan parasite that uses complex methods for destroying the innate immune response in mammalian host macrophage cells. Many factors have been identified that play a role in the severity of the parasite’s pathogenicity. One of the factors is the GP63, which is a group of metalloproteinases that disrupts the signaling mechanism of the host cell. Objectives: The aim of this study was to construct PX-LMGP63 vector through CRISPR-Cas9 for GP63 gene knockout in Leishmania major as a potential method for Leishmanization. Methods: A pair of gRNAs were designed based on the mRNA sequence of the GP63. Then annealing primers were cloned into the linearized vector PX-459 and transformed into the DH5ɑ competent cells. Then, PCR assay was performed with gene-specific and vector primers to confirm the colonies. In addition, the constructed plasmid was sequenced for final confirmation. Results: The expected size band of 270 was confirmed by PCR. The plasmid sequence showed that the gRNA789 was ligated in the vector. The created structure was named PX-LMGP63 and will be transfected into the promastigote cell in the next step. Conclusions: Owing to the prevalence of cutaneous Leishman as a public health problem in most countries and the lack of an effective vaccine for leishmaniasis, the use of the CRISPR method may make it possible to achieve an effective vaccine in the future.
Severity of Respiratory Failure and Outcome of Patients Needing a Ventilatory Support in the Emergency Department During Italian Novel Coronavirus SARS-CoV-2 Outbreak: Preliminary Data on the Role of Helmet CPAP and Non-Invasive Ventilation

Background: Novel Coronavirus SARS-CoV-2 epidemic is spreading around the world. At the end of February, the outburst of the epidemic has hit hard on northern Italian’s hospitals. As of today, no data have been published regarding the severity of respiratory failure of patients presenting to the Emergency Departments. Moreover, the outcome of the patients forced to undergo Continuous Positive Airway Pressure (CPAP) devices or Non-Invasive ventilation (NIV) due to lack of Intensive Care resources is unknown. “Papa Giovanni XXIII” hospital (HPG23) of Bergamo is one of the largest hospitals in the Country, whit an Emergency Department (ED) managing over 100.000 patients per year. Methods: This is a retrospective observational study based on chart review of patients presenting to the Emergency Department of HPG23 from 29/02/2020 to 10/03/2020 with a clinical condition highly suspicious for COVID-19 infection. Registration of admission rates, severity of respiratory failure (ARDS classification), need of respiratory support and outcome of patients treated with a ventilatory were registered on 23rd of March 2020. Results: From 29/02 to 10/03 611 patients with a suspected diagnosis of COVID-19 infection were admitted at our ED; 320 (52%) met the criteria for hospital admission. Among those admitted to the hospital, 99 (31%) needed to be immediately started on ventilatory support (81% CPAP, 7% NIV, 12% Invasive Mechanical Ventilation). Among the patients on ventilatory support, 17% received a diagnosis of mild, 51% of moderate, and 31% of severe ARDS. Eighty-five (86%) of the 99 patients needing a ventilatory support eventually had SARS-CoV-2 infection confirmed by PCR test on nasal-pharyngeal swab. The overall mortality rate as of march, 23rd was 61,2%, ranging from 100% in patients older than 80 years to 0% in those younger than 50 years old. NIV/CPAP failure occurred in 87,1% of patients. Conclusion: The population of patients suspected for COVID-19 infection presenting at our ED showed a very high rate of severe respiratory failure, in urgent need of outstanding intensive care resources. Mortality rates of critically ill patients are similar to previously reported studies. CPAP/NIV can help to reduce the mortality rate among patients that cannot be treated invasively by orotracheal intubation due to lack of intensive care resources. Funding Statement: The authors reported that no funds were received for this research project. Declaration of Interests: Roberto Cosentini reports personal fees from Fisher & Paykel, outside the submitted work None of the other authors have any interest to disclose. Ethics Approval Statement: Study approved by the ethics committee of Bergamo on 01March 2020.
Pengaruh Pendapatan Asli Daerah Dan Dana Perimbangan Terhadap Belanja Modal Dan Tingkat Kemandirian Keuangan Daerah

This study aims to determine the effect of regional original income and balance funds on capital expenditure and the level of local financial independence in district and city governments in Riau Province. The population in this study were all districts and cities in Riau Province from 2010-2018. The sample in this study is a total sampling technique, where the entire population is sampled. The number of districts and cities in Riau Province is 12 districts and cities. analysis conducted using Structural Equation Modeling (SEM). the results of this study indicate that regional own-source revenue and balancing funds have a significant effect on the level of regional financial independence while capital expenditure is not proven to mediate the relationship between regional own-source revenue and the balancing fund with the level of regional financial independence.
Challenges and Strengths of Transitioning to Online Learning during COVID19 University Lockdown: Case Studies from Egypt and Saudi Arabia

The aim of this qualitative study was to explore the experiences of under graduate and post-graduate level students who recently and abruptly transitioned from regular classroom learning to an online learning environment due to the COVID-19 pandemic. Study participants were 30 undergraduate engineering students at the Higher Technological Institute in Egypt, and 20 graduate students enrolled in a Masters TESOL program at King Saud University in Riyadh, Saudi Arabia. All participants completed a 10-item questionnaire regarding their opinions and experiences. Data was analyzed using a six-step thematic approach and was interpreted through the lens of the Community of Inquiry theoretical framework. Findings indicated that online courses strengths included increased student engagement and flexibility, prior familiarity with technology, increased personal time, and the use of multiple learning modalities. Challenges included problems with technology, reduced engagement due to family interruptions, and lack of visual cues. One limitation of this study was the small sample size, which may limit the ability to generalize the findings to other students. These findings provide insight into the issues which can promote or hinder success in online programs.
Adolescent motherhood in rural Nepal: passive sensing data illuminates daily experiences in maternal lives

Background: Adolescent pregnancy, particularly in low-income settings, is associated with adverse health and social outcomes for both mother and child. Nepal has the second highest rate of adolescent pregnancy in South Asia alongside high rates of maternal depression and suicide. While the maternal morbidity risks of adolescent pregnancy are well researched, impacts on everyday lives, including behaviors and predictable patterns are less well-known. Passive sensing (geographic movement, physical activity, and proximity to infants using Bluetooth technology) is an emerging technology that can enhance the detection of behavior patterns. Given the risk of the postpartum period in LMIC settings, we sought to characterize normal behavioral patterns via passive sensing technology. Methods: We collected passive data over a two-week period with 22 mothers using phone-based GPS, accelerometry, and Bluetooth technologies. Passive data was aggregated for each mother, collapsed into hourly readings, and descriptively summarized. We triangulated this information in a constant comparative approach with a range of qualitative data including multiple in-depth interviews, a daily diary, and systematic fieldnotes. Results: Passive data illuminated a range of behaviors that varied across our participants. Women, during the average time window of 4am and 8pm, spent more than 80% of the day with their infants, were detected as ‘active’ 10-20% of the time in any given hour with peaks in the morning and mid-afternoon, and traveled fewer than 1675 meters from their homes. Household work, instrumental childcare, and household support, paired with the infant’s age, appeared to drive activity patterns. Women with higher amounts of activity and GPS movement had more household support for chores and childcare. Women with young infants had smaller amounts of activity and GPS movement. Women that had nearly no time away from their infant expressed overwhelming responsibilities and increased stress, but also role fulfillment in that time with their infant was an indicator of good mothering. Conclusion: We reveal typical behavioral patterns of rural adolescent mothers and highlight opportunities for integrating this information to improve health and well-being.
Taxonomic novelties of saprobic Pleosporales from selected dicotyledons and grasses

Pleosporales is the largest order in the class Dothideomycetes, comprising a quarter of all species of Dothideomycetes. This paper provides comprehensive illustrations and descriptions of newly collected saprobic pleosporalean taxa from dicotyledons and grasses in China, Italy, Russia and Thailand. These species are accommodated in 8 families in Pleosporales. The taxa described here include 14 new species, a new geographical record and three new host records of known species. New species are Alternaria rumicis, Bambusicola ficuum, Comoclathris flammulae, C. europaeae, C. lonicerae, Ophiobolus lathyri, Paraophiobolus torilicola, Parastagonospora dactylidicola, P. hieracioidis, Pseudopaucispora hyalinospora, Stagonospora poaceicola, Stemphylium artemisiae and Subplenodomus meldolanus. All species descriptions presented herein are based on morphological comparisons coupled with multi-gene phylogenetic analyses.
Chromosome count improvement and digitalization of Neolamarckia cadamba

Background: Chromosome count is the only direct way to determine the number of chromosome of a species. This study is often considered trivial that seldom described and discussed in detail. Therefore, it is evitable that chromosome count protocol should be revised and revisited before it becomes obliterated. Our chromosome counts in N. cadamba root tips have encountered challenges that prevent us from obtaining clear micrograph with the correct chromosome number. Several obstacles were determined through micrograph observation such as existing unwanted particles in cells, poor chromosome staining and chromosome crumping. Results: The chromosome counts of Neolamarckia cadamba under optimized procedure yielded 44 chromosomes per nucleus. To overcome these, root tip types, stain types, squashing methods were among factors assessed to obtain clear micrograph. We also apply digital technology in term of online database and graphic software that are open source and freely accessible to the public. Conclusions: Throughout the study, we used a few basic laboratory equipment and chemicals, thus making this study economical and applicable in a basic laboratory. The availability of online digital software and databases provide open-source platforms that will ease the efforts in chromosome count.
Complete Genotype and Clinical Phenotype of Hemophilia B: A Study on Iranian Patients

Background: Hemophilia B which refers to the deficiency or functional defect of factor IX (FIX) is typically an X-linked bleeding condition that arises from heterogeneous mutations of the FIX gene (F9). The number of hemophilia cases in Iran is considerable and currently, about 1118 Iranian patients are suffering from hemophilia B, although a small number of them underwent genetic investigations. Here we assessed molecular defects and also laboratory and clinical findings of 10 Iranian cases with hemophilia B. Materials and Methods: A total of 10 cases with hemophilia B were enrolled in the study. Patients were clinically examined by a hematologist and their previous medical documents were surveyed carefully. Routine coagulation tests and FIX activity and antigen assays were performed for the studied patients. Genotyping of F9 for identifying genetic mutations was conducted by the Sanger sequencing method following PCR amplification of the promoter region and all the eight exons of the F9 gene. Results: The mean age of patients was 4 years (9 months to 16 years) and consanguinity was reported in 80% of cases. Patients were commonly manifested by hematoma (90%), epistaxis (80%), and hemarthrosis (70%) and the severity of the disorder was severe (70%) or moderate (30%). In nine out of 10 patients a genetic defect in F9 gene we detected including three missense (c.304T>C, c.1007T>A, c.191G>A) and three nonsense mutations (c.892C>T, c.880C>T, c.1113C>A). Based on the FIX variant database (http://www.factorix.org), five mutations have been reported previously, but mutation c.1007T>A (p.Ile336Asn) seems to be a novel mutation. Conclusion: Our results indicated the heterogeneous molecular defects of hemophilia B in Iran, as recorded in the FIX mutation database. Moreover, no specific genotype-phenotype association was observed in studied subjects.
Diagnostic and Prognostic Nomograms for Bone Metastasis in Patients With Newly Diagnosed Renal Cell Carcinoma

BackgroundBone metastasis (BM) is one of the common sites of renal cell carcinoma (RCC), and patients with BM have a worse prognosis than those without it. We aimed to develop two nomograms to quantify the risk of BM and predict the prognosis of RCC patients with BM.MethodsWe reviewed patients with newly diagnosed RCC with BM in the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Multivariate logistic regression analysis was used to determine independent predictors of BM in RCC patients. Univariate and multivariate Cox proportional hazards regression analysis was used to determine independent prognostic factors for BM in RCC patients. Diagnostic and prognostic nomograms were established and evaluated by calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA). ResultsThe study included 37554 patients newly diagnosed with RCC in the SEER database, 537 of whom were BM patients. Risk factors for BM in RCC patients included sex, tumor size, liver metastasis, lung metastasis, brain metastasis, N stage, T stage, histologic type, and grade. Independent prognostic factors for RCC with BM were grade, histologic type, N stage, surgery, brain metastasis, and lung metastasis. Calibration, ROC curve, and DCA showed that both diagnostic and prognostic nomograms showed good performance.ConclusionsDiagnostic and prognostic nomograms were established to predict the risk of BM in RCC and the prognosis of RCC with BM, respectively. These nomograms strengthen each patient's prognosis-based decision making, which is of great significance in improving the prognosis of patients.
Lysyl oxidase polymorphisms influence the risk of cancer: an update meta-analysis

The genetics of cancer metastasis is important for designing optimal therapeutic strategies. The lysyl oxidase (LOX) gene has been found important in the metastatic process, with roles in setting the microenvironment for future metastatic sites. Associations between the LOX polymorphisms (473G/A and -22G/C) have been examined in several studies, however, results were inconsistent, prompting a meta-analysis in order to obtain more precise estimates.Searches of six databases yielded 14 articles (15 studies) that examined associations of 473G/A and -22G/C with cancer. We examined five cancer groups: breast, lung, bone (osteosarcoma), GIC (gastrointestinal cancers) and GYC (gynecological cancers). For each cancer group, we calculated pooled odds ratios (ORs) and 95% confidence intervals (CIs) using standard genetic models. High significance (Pa < 0.00001), homogeneity (I2 = 0%) and high precision of effects (CI difference < 1.0 [upper CI-lower CI]) comprised the three criteria for strength of evidence (SOE). Multiple comparisons were Bonferroni-corrected. Sensitivity analysis assessed robustness of the outcomes.Thirteen significant associations indicating increased risk (OR > 1.00) were found in all cancer groups except breast (Pa = 0.10-0.91). Of the 13, two were in osteosarcoma where the -22G/C effects (ORs 4.05-4.07, 95% CIs 1.30-12.70, Pa = 0.02) were homogeneous (I2 = 0%) but imprecise (CIDs 11.4) and did not survive the Bonferroni correction. In contrast, the Bonferroni-surviving dominant/codominant outcomes in lung cancer (OR 1.44, 95% CI 1.19-1.74) and GYC (ORs 1.52-1.62, 95% CIs 1.26-1.88) met all three SOE criteria (Pa = 0.00001, I2 = 0%, CIDs 0.49-0.56). In summary, associations of LOX 473G/A with lung, ovarian and cervical cancers indicate 1.4-1.6-fold increased risks. These outcomes were underpinned by robustness and high statistical power at the aggregate level.
Dynamic changes in home-ranges of the subterranean rodent: a case study on Myospalax baileyi

BackgroundSubterranean rodents, as ecosystem engineers, excavate and inhabit burrow systems. Their underground space-use mobility is poorly recorded. There is conflicting evidence regarding that burrow system of subterranean rodents, once established, are relatively stable because of high-energy costs of digging. For monitoring data at different stages of a year’s life cycle. We predict that mating and habitat characteristics might influence home-range size and locomotion.MethodsThe present study implemented successive radio-tracking in order to quantify the locomotion and overlap of the plateau zokor (Myospalax baileyi) home-range throughout the year. Home-ranges were calculated according to the 100% minimum convex polygon (MCP) methods. We also examined the relationships of home-range sizes with body mass, vegetation biomass, and soil compaction, respectively.ResultsWe found that sizes of home-ranges varied monthly for both male and female, except for the long winter (from November to March of the following year) challenging to excavate with activity ranges of all individuals concentrated on their own nests. During the mating season, the average size of males’ home-ranges is 3.4 times larger than females’ home-ranges. Males likely expanded the burrows to overlap with multiple females and to enhance their chances of mating. However, there was no overlap between estrus females or males, perhaps by reducing encounters and unnecessary fights. Home-ranges between males and females showed similar in size after courtship ends one month, and interestingly, single zokor’s home-range overlapped with the home-ranges of several neighbors. Most individuals remained territorial and excluded intraspecific from their home-ranges. Besides, the position of the females was stable throughout the year, while half of the males shifted nests and established completely new home-ranges in the non-breeding season, mainly in October. ConclusionsWe conclude that space use of M. baileyi is flexible in response to meet physical contact and food resource. Regarding locomotion of home-range, subterranean plateau zokors to affirm that their home-ranges are dynamics and males shift in space with one breeding cycle.