Miracle-dz/UniFAR-FTUs huggingface dataset:
Current-voltage relationship in the auroral particle acceleration region

The current-voltage relationship in the auroral particle acceleration region has been studied statistically by the Akebono (EXOS-D) satellite in terms of the charge carriers of the upward field-aligned current. The Akebono satellite often observed field-aligned currents which were significantly larger than the model value predicted by Knight (1973). We compared the upward field-aligned current estimated by three different methods, and found that low-energy electrons often play an important role as additional current carriers, together with the high-energy primary electrons which are expected from Knight's relation. Such additional currents have been observed especially at high and middle altitudes of the particle acceleration region. Some particular features of electron distribution functions, such as "cylindrical distribution functions" and "electron conics", have often been observed coinciding with the additional currents. They indicated time variability of the particle acceleration region. Therefore, we have concluded that the low-energy electrons within the "forbidden" region of electron phase space in the stationary model often contribute to charge carriers of the current because of the rapid time variability of the particle acceleration region. "Cylindrical distribution functions" are expected to be found below the time-varying potential difference. We statistically examined the locations of "cylindrical distribution function", and found that their altitudes are related to the location where the additional currents have been observed. This result is consistent with the idea that the low-energy electrons can also carry significant current when the acceleration region changes in time.
The PLS model space: the inconsistency persists

In response to the criticisms of Wold et al. 1 , the PLS model‐space inconsistency previously described 2 is expressed in latent‐variable language. The inability of the conventional NIPALS PLS algorithm to recover its own decomposition from an already decomposed matrix is also discussed. Copyright © 2008 John Wiley & Sons, Ltd.
Model of Gait Control in Parkinson’s Disease and Prediction of Robotic Assistance

Gait variability of healthy adults exhibits Long-Range Autocorrelations (LRA), meaning that the stride interval at any time statistically depends on previous gait cycles; and this dependency spans over several hundreds of strides. Previous works have shown that this property is altered in patients with Parkinson’s disease, such that their gait pattern corresponds to a more random process. Here, we adapted a model of gait control to interpret the reduction in LRA that characterized patients in a computational framework. Gait regulation was modeled as a Linear-Quadratic-Gaussian control problem where the objective was to maintain a fixed velocity through the coordinated regulation of stride duration and length. This objective offers a degree of redundancy in the way the controller can maintain a given velocity, resulting in the emergence of LRA. In this framework, the model suggested that patients exploited less the task redundancy, likely to compensate for an increased stride-to-stride variability. Furthermore, we used this model to predict the potential benefit of an active orthosis on the gait pattern of patients. The orthosis was embedded in the model as a low-pass filter on the series of stride parameters. We show in simulations that, with a suitable level of assistance, the orthosis could help patients recovering a gait pattern with LRA comparable to that of healthy controls. Assuming that the presence of LRA in a stride series is a marker of healthy gait control, our study provides a rationale for developing gait assistance technology to reduce the fall risk associated with Parkinson’s disease.
International intercomparison of pressure standards in the pneumatic pressure region 0.4-4.0 MPa between NPL (India) and PTB (FRG)

Describes the results of a comparison of pressure measurement between NPL and PTB using transfer pressure standards over the range of nominal applied pressure 0.4-4.0 MPa, carried out in October 1986 at the National Physical Laboratory, New Delhi. The transfer pressure standards used during the comparison are the piston gauges, NPL-4 with a nominal effective area 8.392 196*10-6 m2 at 20 degrees C and PTB-4 with a nominal effective area 98.049 02*10-6 m2 at 20 degrees C. The comparison data thus obtained are analysed in terms of the accuracy achieved in the determination of the effective area of the piston gauges used. The effective area obtained for NPL-4 from the NPL main standard agrees with 1 p.p.m. with the value derived from the calibration using the PTB-4 standard. The mean value of the deviation of the pressure is 8 p.p.m. , which is considered to be in good agreement within the uncertainty statement of the respective standards as deduced from the primary standards. Also determined are the zero-pressure values of the effective area of the NPL-8 reference standard by comparing it with NPL-4 and PTB-4 transfer standards. The consistency of the results clearly indicates that the measurements taken by using the calibration data for the transfer pressure standards NPL-4 and PTB-4 are compatible.
Distal Nerve Transfers in High Peroneal Nerve Lesions: An Anatomical Feasibility Study

The peroneal nerve is one of the most commonly injured nerves of the lower extremity. Nerve grafting has been shown to result in poor functional outcomes. The aim of this study was to evaluate and compare anatomical feasibility as well as axon count of the tibial nerve motor branches and the tibialis anterior motor branch for a direct nerve transfer to reconstruct ankle dorsiflexion. In an anatomical study on 26 human body donors (52 extremities) the muscular branches to the lateral (GCL) and the medial head (GCM) of the gastrocnemius muscle, the soleus muscle (S) as well as the tibialis anterior muscle (TA) were dissected, and each nerve’s external diameter was measured. Nerve transfers from each of the three donor nerves (GCL, GCM, S) to the recipient nerve (TA) were performed and the distance between the achievable coaptation site and anatomic landmarks was measured. Additionally, nerve samples were taken from eight extremities, and antibody as well immunofluorescence staining were performed, primarily evaluating axon count. The average diameter of the nerve branches to the GCL was 1.49 ± 0.37, to GCM 1.5 ± 0.32, to S 1.94 ± 0.37 and to TA 1.97 ± 0.32 mm, respectively. The distance from the coaptation site to the TA muscle was 43.75 ± 12.1 using the branch to the GCL, 48.31 ± 11.32 for GCM, and 19.12 ± 11.68 mm for S, respectively. The axon count for TA was 1597.14 ± 325.94, while the donor nerves showed 297.5 ± 106.82 (GCL), 418.5 ± 62.44 (GCM), and 1101.86 ± 135.92 (S). Diameter and axon count were significantly higher for S compared to GCL as well as GCM, while regeneration distance was significantly lower. The soleus muscle branch exhibited the most appropriate axon count and nerve diameter in our study, while also reaching closest to the tibialis anterior muscle. These results indicate the soleus nerve transfer to be the favorable option for the reconstruction of ankle dorsiflexion, in comparison to the gastrocnemius muscle branches. This surgical approach can be used to achieve a biomechanically appropriate reconstruction, in contrast to tendon transfers which generally only achieve weak active dorsiflexion.
Immunotherapy associated central nervous system complications in primary brain tumors

Advances clarifying the genetics and function of the immune system within the central nervous system (CNS) and brain tumor microenvironment have led to increasing momentum and number of clinical trials using immunotherapy for primary brain tumors. While neurological complications of immunotherapy in extra-cranial malignancies is well described, the CNS toxicities of immunotherapy in patients with primary brain tumors with their own unique physiology and challenges are burgeoning. This review highlights the emerging and unique CNS complications associated with immunotherapy including checkpoint inhibitors, oncolytic viruses, adoptive cell transfer/chimeric antigen receptor (CAR) T cell and vaccines for primary brain tumors, as well as reviews modalities that have been currently employed or are undergoing investigation for treatment of such toxicities.
On application of two superconvergent recovery procedures to plate problems

In this paper a study is performed on application of two recovery methods, i.e. superconvergent patch recovery (SPR) and the recovery by equilibrium of patches (REP), to plate problems. The two recovery methods have been recognized to give similar results in adaptive solutions of two dimensional stress problems. While the former applies a least square fit over a set of values at the so called superconvergent points, the latter does not need any knowledge of such points and thus has a wider application especially in non‐linear problems. The formulation of REP is extended to Reissner–Mindlin plate problems. The convergence rates of the recovered fields of the gradients obtained from application of the two methods are compared using series of regular triangular and rectangular meshes for thick and thin plate solution cases. Assumed strain formulation based elements, i.e. the elements formulated by mixed interpolation of tensorial components, as well as conventional from of elements based on selective integration schemes are employed for the study.
On a generalized arcangeli's method for tikhonov regularization with inexact data

A class of parameter choice strategies which include an approximated version of the Arcangeli's method is considered for ill-posed operator equations when the data are not known exactly. A particular case of the method is a generalization and modification of the Marti's method, in which case the results include, and in certain cases improve the conclusions of Engl and Neubauer (1985) under weaker conditions.
Epigenetic reprogramming in pancreatic premalignancy and clinical implications

Pancreatic cancer (PC) is the most lethal human cancer, with less than 10% 5-year survival. Pancreatic premalignancy is a genetic and epigenomic disease and is linked to PC initiation. Pancreatic premalignant lesions include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN), with pancreatic acinar-to-ductal metaplasia (ADM) as the major source of pancreatic premalignant lesions. Emerging evidence reveals that an epigenetic dysregulation is an early event in pancreatic tumorigenesis. The molecular mechanisms of epigenetic inheritance include chromatin remodeling; modifications in histone, DNA, and RNA; non-coding RNA expression; and alternative splicing of RNA. Changes in those epigenetic modifications contribute to the most notable alterations in chromatin structure and promoter accessibility, thus leading to the silence of tumor suppressor genes and/or activation of oncogenes. The expression profiles of various epigenetic molecules provide a promising opportunity for biomarker development for early diagnosis of PC and novel targeted treatment strategies. However, how the alterations in epigenetic regulatory machinery regulate epigenetic reprogramming in pancreatic premalignant lesions and the different stages of their initiation needs further investigation. This review will summarize the current knowledge of epigenetic reprogramming in pancreatic premalignant initiation and progression, and its clinical applications as detection and diagnostic biomarkers and therapeutic targets in PC.
Physical-Layer Authentication for Ambient Backscatter-Aided NOMA Symbiotic Systems

Ambient backscatter communication (AmBC) and non-orthogonal multiple access (NOMA) are two promising technologies for the future wireless communication networks owing to their high energy and spectral efficiencies. The AmBC-aided NOMA symbiotic radio is a promising technology because of possessing advantages of AmBC and NOMA. Nonetheless, when a number of devices with limited power and computation capability access to the AmBC-based NOMA symbiotic networks, communication security becomes a critical issue. In this paper, we investigate physical-layer authentication (PLA) to identify the users and prevent illegal access and malicious activities for AmBC-based NOMA symbiotic networks. Moreover, channel estimation errors are considered when calculating the probability of false alarm (PFA) and probability of detection (PD) of the far user and near user. To enhance the authentication performance, three PLA schemes for the considered networks are designed according to the multiplexing form of the authentication tags: i) PLA with shared authentication tag (PLA-SAT); ii) PLA with space division multiplexing authentication tags; iii) PLA with time-division multiplexing authentication tags. To characterize the proposed PLA schemes, we first derive the PFA and the PD of the considered AmBC-based NOMA symbiotic networks. Then, the covertness is studied in terms of outage probability and asymptotic behavior in the high signal-to-noise ratio regime. Extensive analytical and computer simulated results show that: i) The PLA-SAT scheme has better performance than the other two authentication schemes with the same threshold; ii) The outage performance of systems employing authentication schemes is worse than those without authentication; iii) There exists a trade-off between robustness and covertness.
Untargeted Metabolomics for Integrative Taxonomy: Metabolomics, DNA Marker-Based Sequencing, and Phenotype Bioimaging

Integrative taxonomy is a fundamental part of biodiversity and combines traditional morphology with additional methods such as DNA sequencing or biochemistry. Here, we aim to establish untargeted metabolomics for use in chemotaxonomy. We used three thallose liverwort species Riccia glauca, R. sorocarpa, and R. warnstorfii (order Marchantiales, Ricciaceae) with Lunularia cruciata (order Marchantiales, Lunulariacea) as an outgroup. Liquid chromatography high-resolution mass-spectrometry (UPLC/ESI-QTOF-MS) with data-dependent acquisition (DDA-MS) were integrated with DNA marker-based sequencing of the trnL-trnF region and high-resolution bioimaging. Our untargeted chemotaxonomy methodology enables us to distinguish taxa based on chemophenetic markers at different levels of complexity: (1) molecules, (2) compound classes, (3) compound superclasses, and (4) molecular descriptors. For the investigated Riccia species, we identified 71 chemophenetic markers at the molecular level, a characteristic composition in 21 compound classes, and 21 molecular descriptors largely indicating electron state, presence of chemical motifs, and hydrogen bonds. Our untargeted approach revealed many chemophenetic markers at different complexity levels that can provide more mechanistic insight into phylogenetic delimitation of species within a clade than genetic-based methods coupled with traditional morphology-based information. However, analytical and bioinformatics analysis methods still need to be better integrated to link the chemophenetic information at multiple scales.
The Frequency of Mergers in Compact Groups

The far-infrared colors, optical morphologies, and emission-line rotation curves of galaxies in compact groups are used to estimate the number of these galaxies which are currently merging. Each of these independent methods indicates that roughly 7% of the galaxies in compact groups are in the process of merging. Although each technique is somewhat uncertain, the agreement among the independent methods for the fraction of ongoing mergers and the generally good correlation between different measures of merging for individual systems lend added weight to the results
Surveillance on ESBL-Escherichia coli and Indicator ARG in Wastewater and Reclaimed Water of Four Regions of Spain: Impact of Different Disinfection Treatments

In the present study, the occurrence of indicator antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) both in the influent and the effluent of four Spanish wastewater treatment plants (WWTPs) was monitored for 12 months, and the susceptibility profiles of 89 recovered extended spectrum β-lactamase (ESBL)-producing Escherichia coli isolates were obtained against a wide range of antimicrobials. The aim of the study was to better understand whether the current wastewater treatment practices allow us to obtain safe reclaimed water mitigating the spread of ARB and ARGs to the environment. Results showed high concentrations of ESBL-producing E. coli as well as a high prevalence of a range of ARGs in the influent samples. The reclamation treatments implemented in the WWTPs were effective in reducing both the occurrence of ESBL E. coli and ARGs, although significant differences were observed among WWTPs. Despite these reductions in occurrence observed upon wastewater treatment, our findings suggest that WWTP effluents may represent an important source of ARGs, which could be transferred among environmental bacteria and disseminate antimicrobial resistance through the food chain. Remarkably, no major differences were observed in the susceptibility profiles of the ESBL E. coli isolated from influent and effluent waters, indicating that water treatments do not give rise to the emergence of new resistance phenotypes.
On sets of PP-generators of finite groups

The classes of finite groups with minimal sets of generators of fixed cardinalities, named ${\mathcal{B}}$ -groups, and groups with the basis property, in which every subgroup is a ${\mathcal{B}}$ -group, contain only $p$ -groups and some $\{p,q\}$ -groups. Moreover, abelian ${\mathcal{B}}$ -groups are exactly $p$ -groups. If only generators of prime power orders are considered, then an analogue of property ${\mathcal{B}}$ is denoted by ${\mathcal{B}}_{pp}$ and an analogue of the basis property is called the pp-basis property. These classes are larger and contain all nilpotent groups and some cyclic $q$ -extensions of $p$ -groups. In this paper we characterise all finite groups with the pp-basis property as products of $p$ -groups and precisely described $\{p,q\}$ -groups.
Influence of Flavonoid-Rich Fraction of Monodora tenuifolia Seed Extract on Blood Biochemical Parameters in Streptozotocin-Induced Diabetes Mellitus in Male Wistar Rats

Diabetes mellitus is a metabolic disorder caused by either the total destruction of the pancreatic beta cells that secrete insulin for the uptake of glucose from the circulation or as a result of the inability of body cells to respond to the presence of insulin in the blood. The present study investigated the effect of a flavonoid-rich fraction of Monodora tenuifolia seed extract (FFMTSE) on blood parameters in streptozotocin (STZ)-induced diabetic male Wistar rats. The rats were divided into seven groups (n = 6). Group 1: normal control rats, Group 2: rats + FFMTSE (25 mg/kgbwt), Group 3: rats + FFMTSE (50 mg/kgbwt), Group 4: diabetic control rats, Group 5: diabetic rats + FFMTSE (25 mg/kgbwt), Group 6: diabetic rats + FFMTSE (50 mg/kgbwt), and Group 7: diabetic rats + Metformin. The assessment of the lipid profile, kidney functions (urea and creatinine), and cardiac biomarkers (LDH and CK-MB) were carried out in the plasma using established protocols. The results showed a significant increase in the concentrations of triacylglycerol, cholesterol, LDL-cholesterol, VLDL-cholesterol, urea, and creatinine, as well as in cardiac enzyme activities in diabetic rats. However, the administration of the FFMTSE significantly improved the observed biochemical parameters. In addition, an increased concentration of HDL-cholesterol concentration was observed in the diabetic rats upon treatment with FFMTSE. These findings indicate that FFMTSE could be a potent anti-nephropathy and anti-cardiomyopathy agent in diabetic conditions.
Summarizing Monte Carlo Results in Methodological Research: The One- and Two-Factor Fixed Effects ANOVA Cases

Meta-analytic methods were used to integrate the findings of a sample of Monte Carlo studies of the robustness of the F test in the one- and two-factor fixed effects ANOVA models. Monte Carlo results for theWelch (1947) and Kruskal-Wallis (Kruskal & Wallis, 1952) tests were also analyzed. The meta-analytic results provided strong support for the robustness of the Type I error rate of the F test when certain assumptions were violated. The F test also showed excellent power properties. However, the Type I error rate of the F test was sensitive to unequal variances, even when sample sizes were equal. The error rate of the Welch test was insensitive to unequal variances when the population distribution was normal, but nonnormal distributions tended to inflate its error rate and to depress its power. Meta-analytic and exact statistical theory results were used to summarize the effects of assumption violations for the tests.
Resonance generation of photons from vacuum in cavities due to strong periodical changes of conductivity in a thin semiconductor boundary layer

We study a possibility of photon generation from vacuum in a cavity with an artificial effective time-dependent plasma mirror, which could be created by mean so fp eriodical short laser pulses, illuminating a thin semiconductor slab . W et ak ei nto account two important circumstances: a big imaginary part of the complex time-dependent dielectric permeability inside the slab and a strong dependence of this imaginary part on the distance from the surface of the slab. We find the conditions under which the usual unitary quantization schemes in time-dependent media with real dielectric permeability can be applied to the problem concerned with relatively small (a few per cent) error. We show that, by using a slab with thickness of the order of 1 mm, it is possible to generate a large number of microwave (GHz) photons (up to 10 8 or more) after several thousand picosecond pulses with repetition frequency of the order of 1 GHz, provided that semiconductor materials with high mobility of carriers, high photoabsorption efficiency and smal lr ecombination time (less than 1 ns) can be found. We discuss the possible advantages of modes with TM polarization over TE ones, as well as some other important problems to be solved.