Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Periodontitis, Implant, and Prosthesis Characteristics on the Peri-Implant Status: A Cross-Sectional Study

Background The association between peri-implant diseases and the periodontal, implant, and prosthesis characteristics has been characterized in various ways. Purpose The aim of this study was to evaluate the link between the peri-implant and periodontal status and the influence of implant and prosthesis parameters during implant follow-up. Materials and Methods One hundred and seven patients with a total of 310 implants that had at least one year of function who were attending periodontal and implant maintenance at a university clinic setting were included in this cross-sectional study. The demographic, periodontal, peri-implant tissue, implant, and prosthesis parameters were recorded. A pocket depth > 4 mm with bleeding on probing defined periodontal/peri-implant soft tissue diseased sites. Analyses were performed at the patient and implant levels using univariable and multivariable mixed regression analysis. Results The mean implant follow-up was 7.22 years. At the patient level, the bleeding on probing and pocket depth measurements were more pronounced around the implant than around the teeth. The opposite was observed for plaque and the clinical attachment levels. At the implant level, multivariable analysis showed that the periodontal and corresponding peri-implant tissue parameters, such as diseased sites, were closely related. The implant location, bone level, and number were selectively associated with the implant bone level, while cemented retention and emergence restoration profile influenced the implant pocket depth. Conclusions The present study suggested that clinical peri-implant and periodontal soft tissue statuses were different, which could be a consequence of the initial implant and prosthesis healing process. However, during implant follow-up, the peri-implant parameters were predominantly associated with their corresponding periodontal parameters regardless of an association with the implant and prosthesis characteristics. This trial is registered with ClinicalTrials.gov ID: NCT03841656.
Focusing, the felt sense, and meaning in life

ABSTRACT Making sense of our existence is one of the most demanding aspects of being human. Studies have shown that meaning is robustly associated with well-being and mental health. In this study with 358 Dutch-speaking participants during the covid-19 pandemic, we tested if the practice of contacting one’s felt sense (focusing attitude) would predict life satisfaction, psychological distress, and existential anxiety. We also tested whether the effect of this focusing attitude would be partially mediated by the experience of meaning in life. Our hypotheses were confirmed. This suggests that the focusing attitude predicts more life satisfaction, less psychological distress, and less existential anxiety. The associations are also partially mediated by the experience of meaning in life. Focusing training variables suggested that attending one’s felt sense can be learned. However, our study also suggests that focusing-partnership deserves closer study.
Predicting Falls in Long-term Care Facilities: Machine Learning Study

Background Short-term fall prediction models that use electronic health records (EHRs) may enable the implementation of dynamic care practices that specifically address changes in individualized fall risk within senior care facilities. Objective The aim of this study is to implement machine learning (ML) algorithms that use EHR data to predict a 3-month fall risk in residents from a variety of senior care facilities providing different levels of care. Methods This retrospective study obtained EHR data (2007-2021) from Juniper Communities’ proprietary database of 2785 individuals primarily residing in skilled nursing facilities, independent living facilities, and assisted living facilities across the United States. We assessed the performance of 3 ML-based fall prediction models and the Juniper Communities’ fall risk assessment. Additional analyses were conducted to examine how changes in the input features, training data sets, and prediction windows affected the performance of these models. Results The Extreme Gradient Boosting model exhibited the highest performance, with an area under the receiver operating characteristic curve of 0.846 (95% CI 0.794-0.894), specificity of 0.848, diagnostic odds ratio of 13.40, and sensitivity of 0.706, while achieving the best trade-off in balancing true positive and negative rates. The number of active medications was the most significant feature associated with fall risk, followed by a resident’s number of active diseases and several variables associated with vital signs, including diastolic blood pressure and changes in weight and respiratory rates. The combination of vital signs with traditional risk factors as input features achieved higher prediction accuracy than using either group of features alone. Conclusions This study shows that the Extreme Gradient Boosting technique can use a large number of features from EHR data to make short-term fall predictions with a better performance than that of conventional fall risk assessments and other ML models. The integration of routinely collected EHR data, particularly vital signs, into fall prediction models may generate more accurate fall risk surveillance than models without vital signs. Our data support the use of ML models for dynamic, cost-effective, and automated fall predictions in different types of senior care facilities.
Unveiling the Hidden Entropy in ZnFe2O4

The antiferromagnetic (AFM) transition of the normal ZnFe2O4 has been intensively investigated with results showing a lack of long-range order, spin frustrations, and a “hidden” entropy in the calorimetric properties for inversion degrees δ ≈ 0 or δ = 0. As δ drastically impacts the magnetic properties, it is logical to question how a δ value slightly different from zero can affect the magnetic properties. In this work, (Zn1-δFeδ)[ZnδFe2-δ]O4 with δ = 0.05 and δ = 0.27 have been investigated with calorimetry at different applied fields. It is shown that a δ value as small as 0.05 may affect 40% of the unit cells, which become locally ferrimagnetic (FiM) and coexists with AFM and spin disordered regions. The spin disorder disappears under an applied field of 1 T. Mossbauer spectroscopy confirms the presence of a volume fraction with a low hyperfine field that can be ascribed to these spin disordered regions. The volume fractions of the three magnetic phases estimated from entropy and hyperfine measurements are roughly coincident and correspond to approximately 1/3 for each of them. The “hidden” entropy is the zero point entropy different from 0. Consequently, the so-called “hidden” entropy can be ascribed to the frustrations of the spins at the interphase between the AFM-FiM phases due to having δ ≈ 0 instead of ideal δ = 0.
Systemic Effects of mitoTEMPO upon Lipopolysaccharide Challenge Are Due to Its Antioxidant Part, While Local Effects in the Lung Are Due to Triphenylphosphonium

Mitochondria-targeted antioxidants (mtAOX) are a promising treatment strategy against reactive oxygen species-induced damage. Reports about harmful effects of mtAOX lead to the question of whether these could be caused by the carrier molecule triphenylphosphonium (TPP). The aim of this study was to investigate the biological effects of the mtAOX mitoTEMPO, and TPP in a rat model of systemic inflammatory response. The inflammatory response was induced by lipopolysaccharide (LPS) injection. We show that mitoTEMPO reduced expression of inducible nitric oxide synthase in the liver, lowered blood levels of tissue damage markers such as liver damage markers (aspartate aminotransferase and alanine aminotransferase), kidney damage markers (urea and creatinine), and the general organ damage marker, lactate dehydrogenase. In contrast, TPP slightly, but not significantly, increased the LPS-induced effects. Surprisingly, both mitoTEMPO and TPP reduced the wet/dry ratio in the lung after 24 h. In the isolated lung, both substances enhanced the increase in pulmonary arterial pressure induced by LPS observed within 3 h after LPS treatments but did not affect edema formation at this time. Our data suggest that beneficial effects of mitoTEMPO in organs are due to its antioxidant moiety (TEMPO), except for the lung where its effects are mediated by TPP.
Could Self-Reported Body Sizes Be an Alternative Tool for Assessing Breast Cancer Risk in Postmenopausal Women?

Background: The use of self-reported body size as an alternative tool to estimate body weight for health risk assessment is not widely reported, especially in relation to breast cancer. Therefore, we examined the association between breast cancer and body-mass index (BMI) and the usefulness of pictograms. Methods: The case–control study was conducted among postmenopausal women from 2015 to 2019. The study involved 151 women with breast cancer and 67 control subjects. Data were collected by a self-reported detailed questionnaire. Results: An increased, 4.13-fold risk of breast cancer (OR = 4.13; 95% CI [1.69, 10.28]) was observed for women with BMI 25.0–29.9 kg/m2 compared to women with normal BMI (18.5–24.9 kg/m2), whereas the association in the case of obese women was not statistically significant. An increased risk of breast cancer was observed for pictogram scores 3–4 (OR = 8.95; 95% CI [3.22, 24.88]) and for the highest level of self-reported body size, pictograms ≥ 5 (OR = 3.20; 95% CI [1.13, 9.09]). Conclusions: The risk of breast cancer is associated with an increased BMI and visual overweigh and obesity. The results suggest that a self-reporting alternative tool can be used to assess the prevalence of overweight/obesity, particularly in situations where no other tools are available.
Knowledge, Attitude and Practice Analysis of Antibiotics Use and Misuse in Tertiary Care Rural Hospital Patients

Introduction: In recent decades, the increase in bacterial resistance against all major antibiotics is a growing worldwide problem and is a significant threat to global public health in the 21century. Objective: Assess the knowledge, attitude, and practice of antibiotics use and misuse among the tertiary care rural hospital patients. Methods: This is a cross-sectional analytical study conducted at tertiary care teaching rural hospital in India between December2020 to April 2021. A self-administered questionnaire was distributed to the patients of outpatient departments in hospital. The questionnaire consisted of 3 parts, first part consist of demographic variables, second and third part regarding knowledge, attitude and practice of patients towards use of antibiotics. SPSS 21 was used for data analysis. Results: Out of the 110 participants, 56(50.91%) were males and 54(49.09%) were females. 55(50%) patients received antibiotics from friends, relative and pharmacist without medical doctor checkup. 38(34.55%) patients had started antibiotics as preventive medication for any infection, 73 (66.36%) patients got better earlier and have stopped. 52(47%) patient expect antibiotics from doctor for common cold. 42% patient obtained antibiotics without valid prescription from relatives, pharmacist or self-prescription without producing valid prescription obtained from the doctor. In the knowledge domain while majority of respondent were well aware that antibiotics are hazardous during pregnancy and lactation and can lead to severe allergic reactions. But very few respondent knew about resistance can transfer from animal to human and human to human, also very few respondent knew about antibiotics can alter human body bacterial flora. Conclusion: There is lack of knowledge regarding antibiotics use and resistance among general population. Strict strategies need to employ like antibiotics prescription audit, antibiotics dispensing monitoring, effective public health education, and promoting health worker and patient communication.
A Narrative Review of the Use of Augmented and Virtual Reality as an Alternate to Traditional Mirror Therapy in Dealing with Post Amputation Phantom Limb Pain (PLP)

This article reviews the existing data on the use of augmented and virtual reality in the treatment of post amputation phantom limb pain (PLP) in order to curb the shortcomings of the treatment modality already in place: traditional mirror therapy. PLP is a highly prevalent condition- as high as used in 65%-70% amputees, which has many therapies in place varying from medicinal options such as anaesthetics, drugs that help cure depression and injections of botulism toxin, inter-positional treatments such as stimulation of spinal cord, correctional surgery and more. Visio- dynamic approaches such as reflective surface therapy (mirror) and augmented reality treatments which attempt at normalizing the representation of the amputated limb from the cortex and improving the correlation between the authentic and anticipated sensory feedback. Previous studies have consistently demonstrated the efficacy of traditional therapy using mirrors in post upper limb amputation PLP where a setup with a mirror is used to trick the mind of the patient in making the patient see a reflection of the good limb and exercising it to give the effect of exercise of the amputated limb, however because of its crude setup, it proves to have a few limitations which can be overcome using virtual reality. Virtual reality is integrating in our lives today as video games and simulations. It has a lot of application in diagnosing, prophylaxis and treatment. Virtual reality is a boon to the medical field in the sense that it allows one to visualize and practice endlessly without needing any additional resources. Incorporating VR into the treatment, patient centered holistic care can be achievable and patient's quality of life and satisfaction can be improved.
Stroke Traditional Therapy in the Community in Indonesia

Stroke is a major cause of death and disability which must be treated quickly and appropriately. Use of complementary and alternative Medicine is high for stroke patients. The purpose of this study was to explore the use of stroke traditional therapy in the community setting. This study was an ethnographic study, and it aimed to identify social interactions, behaviors, and perceptions. This study involved seven key informants (families of stroke patients), recruited through a purposive sampling technique until data saturation was reached. Participant observation, in-depth interviews, and focus group discussions were employed in this study from December 2018 to February 2019. Data analysis involved content analysis. There were five themes identified in this study: family, traditional healer, neighbors, other people, and friends. The family refers to their spouse, children, nieces/nephews, sons-in-law, siblings, and grandchildren. Other people are also involved such as masseurs, neighbors, parking attendants, pedicab drivers, and friends. People who are involved in stroke traditional therapy should also be able to provide conventional treatments such as medicines, and carry out therapy with physiotherapists. Keywords: stroke, community, traditional therapy, ethnography
Study on Energy Distribution Characteristics of Seismic Waves Induced by Different Forms of Blasting Resource

The effect of blast-induced seismic waves on buildings can be considered as a transferred and transformed process of the energy,which relates to the energy distribution characteristic of blasting vibration.An energy analysis method for blasting vibration signals based on power spectrum was put forward.Based on a large number of measurement data,the energy distribution characteristics of seismic waves induced by different forms of blasting resource were studied.The result shows that for blasting vibration induced by four kinds of drilling-and-blasting,the energy distribution with frequency is scattered.The seismic energy of low-frequency from 0 Hz to 10 Hz is very little.The energy distribution characteristics vary with the different types of drilling-and-blasting.As diameter and depth of the blasting hole increases,the frequency band of energy distribution becomes more focus and has the trend of moving to the lower frequency,and for underground blasting,the seismic energy below 40 Hz is very little.The energy distribution characteristic of seismic waves induced by different forms of blasting resource can have guiding role for choosing the appropriate type of drilling-and-blasting when the effect of blasting vibration needs to be controlled.
The Nutritional Quality and Structural Analysis of Black Soldier Fly Larvae Flour before and after Defatting

Simple Summary The increasing global population and consumer demand for protein will render the provision of protein a serious future challenge, thus placing substantial pressure on the food industry to provide for the human population. The lower environmental impact of insect farming makes the consumption of insects such as black soldier fly larvae (BSFL) an appealing solution, although consumers in developed countries often respond to the idea of eating insects with aversion. One approach to adapt consumers to insects as part of their diet is through the application of making insect-based products in an unrecognized form. Nutritional value and structural properties of the BSFL flours (full fat and defatted) were assessed. Defatted as well as full-fat flour both displayed good nutritional and structural characteristics for use in many food applications. Abstract This study aimed to assess the nutritional information and structural overview of the BSFL (black soldier fly larva) flours (full fat and defatted). The BSFL flours were obtained by freeze-drying the larvae and the removal of fat using hexane and isopropanol ratio of 3:2 (v/v), these solvents were used due to their defatting efficiency and because they are less toxic. Nutritional and structural analyses were conducted using standard methods. The full-fat and defatted flours had high protein content (45.82% and 56.11% respectively). Defatting significantly (p < 0.05) increases the protein content by approximately 10%, while the fat content decreased from 25.78% in full-fat larvae to 4.8% in defatted larvae. The compositional data were qualitatively confirmed with Universal Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (UATR-FTIR) mainly in the amide I and II regions. Thermal gravimetry (TG) and differential scanning calorimeter (DSC) analysis, showed the conformational physical changes induced due to removal of fat which affected protein denaturation. DSC analysis displayed curves of both endothermic and exothermic reactions. During the first heating program, both samples had wide endothermic heating peaks ranging from 42 to 112 °C, which may be attributed to the water content in the samples evaporating. The first stage of the decomposition process was important, with loss of free and loosely bound water up to 150 °C, according to TGA curves. Protein and carbohydrates volatilized during the second stage of decomposition. The third level may be linked to polypeptide decomposition. FTIR revealed that the defatting process induced structural modifications on the amide I (1650 cm−1) and amide II (1540 cm−1) regions. Defatting has a significant effect on the functional groups and nutritional value of the BSFL. Defatted as well as full-fat flour both show good nutritional and structural characteristics for use in many food applications, however the improved proximate composition of the defatted BSFL can be applied to food products using BSFL flour as an alternative ingredient.
The Effect of Health Promotion on Family Knowledge and Attitude in Preventing the COVID-19 Pandemic

COVID-19 has different genetic characteristics from other corona viruses such as SARSr-CoV and MERSr-CoV. There are still many positive cases of COVID-19 every day. There are nine people who monitor cases of COVID-19 in Baleendah Village. The Baleendah location is surrounded by areas that are already badly affected by COVID-19. This pandemic necessitates health promotion through the family to prevent the transmission of COVID-19. This study aimed to identify the impact of providing health promotion to families on knowledge and attitudes in preventing COVID-19 in the Rancamanyar cluster. This was a pre-experimental study with a one group pre-test and post-test design, using a sample of 74 respondents. The method of collecting data was through a questionnaire that was shared via Google Drive through an online system. Health promotion significantly influenced family knowledge and attitudes in preventing COVID-19. Based on the findings, it is recommended that public knowledge be increased so that the public is aware of how to prevent the transmission of COVID-19 to other people and to other family members. Keywords: COVID-19 prevention, health promotion, family knowledge and attitudes
Cognitive Impairment in Anti-Phospholipid Syndrome and Anti-Phospholipid Antibody Carriers

Cognitive impairment is frequently reported among anti-phospholipid syndrome (APS) patients as well as anti-phospholipid antibody (aPL) carriers, but it is less studied than other manifestations of this condition. Moreover, the exact prevalence of cognitive impairment in these patients has not been accurately determined, mainly due to inconsistency in the tools used to identify impairment, small sample sizes, and variability in the anti-phospholipid antibodies measured and positivity cutoffs. The notion of a direct pathogenic effect is supported by the observation that the higher the number of aPLs present and the higher the load of the specific antibody, the greater the risk of cognitive impairment. There is some evidence to suggest that besides the thrombotic process, inflammation-related pathways play a role in the pathogenesis of cognitive impairment in APS. The cornerstone treatments of APS are anti-coagulant and anti-thrombotic medications. These treatments have shown some favorable effects in reversing cognitive impairment, but solid evidence for the efficacy and safety of these treatments in the context of cognitive impairment is still lacking. In this article, we review the current knowledge regarding the epidemiology, pathophysiology, clinical associations, and treatment of cognitive impairment associated with APS and aPL positivity.
Career Preference and Factors Influencing Career Choice among Undergraduate Pharmacy Students at University of Khartoum, Sudan

The pharmacy profession has expanded and adapted to changes in community needs. Although career planning and understanding the determinants of career choice are essential, there remains a lack of studies exploring factors influencing future career plans. This study was conducted to identify career preferences and factors influencing future career choices among undergraduate pharmacy students. A cross-sectional study was carried out at the Faculty of Pharmacy, University of Khartoum. A self-administered questionnaire was used to collect data from randomly selected participants. Out of 220 respondents, 85.9% were females. The average age of the respondents was 21.7 ± 1.5 years. Clinical pharmacy was selected as the most preferred future career domain (30%), followed by academia and research (12%), the pharmaceutical industry (11%), and community pharmacy (10.5). Approximately 20% of participants reported a preference for moving abroad for work. Regarding factors influencing future career domain choice, participants ranked training in the workplace (80%) and curriculum content (70%) as the top faculty-related factors, while interaction with practicing pharmacists (71.8%) and salary (78%) were the major personal-related and job-related factors. This study emphasized the importance of understanding job preferences and the factors influencing career choice, and could be useful in ensuring a future balance between professional domains and meeting society’s evolving expectations.