Miracle-dz/UniFAR-FTUs huggingface dataset:
Observational study on passive leg raising and the autonomic nervous system

In the intensive care and perioperative setting, circulation is often supported by intravenous fluid preceded by prediction of fluid responsiveness during a passive leg raising (PLR) maneuver. An increase in stroke volume (SV) or cardiac output (CO) of 10%–15% indicates that the subject may increase the flow upon volume expansion. However, the semi‐recumbent position as an initial position in PLR likely reduces SV by gravitational displacement of central blood volume (CBV) to lower extremities, thereby accentuating volume responsiveness during leg raising in healthy people. Coincident with gravitational perturbations in hemodynamics, remedial changes occur in the autonomic nervous system (ANS), as expressed in spectral power in heart rate variability (HRV). This study aims to clarify these concomitant changes during PLR. A convenience number of healthy volunteers (N = 11) were recruited by advertisement in university departments. The subjects were exposed to the established PLR sequence and the heart rate (HR), mean arterial pressure (MAP), SV, and CO were sampled at 1 Hz, while electrocardiogram was recorded at 1000 Hz. Relative powers reflecting autonomic nervous system activity were assessed from spectral analysis of HRV. In response to PLR, SV increased (12.4% ± 8.7%, p < 0.0026), while HR (−7.6% ± 4.7%, p < 0.0009) and MAP (−7.6% ± 6.9%, p < 0.01) decreased, with no change in CO (4.1% ± 12.8%, ns). The HRV low‐frequency component was reduced (−34%; p < 0.0095), while the high‐frequency activity increased (78.5%; p < 0.0013), with a 63% decrease in the low/high frequency ratio (p < 0.0078). Thus, HRV indicated a reduced sympathetic index (semi‐recumbent 0.808 vs. PLR −0.177 a.u., p < 0.001) and an increased parasympathetic index (−0.141 to 0.996 a.u., p < 0.0001). Gravitational depletion and expansion of CBV during PLR were associated with a counterregulatory autonomic response. Healthy volunteers appeared volume responsive in terms of SV, but not CO. Responses to PLR are influenced by the ANS, and HRV analysis should be included in the assessment of the PLR test.
Using Creative Approaches and Facilitating Remote Online Focus Groups With Children and Young People: Reflections, Recommendations and Practical Guidance

The importance of engaging and involving children and young people (CYP) in research is widely recognised, especially for educational research exploring CYP’s perceptions and experiences of school processes. Historically, working with CYP to collect qualitative data has involved face-to-face interactions, however the social distancing requirement during the COVID-19 pandemic meant there was a need to move ‘online’ and work ‘remotely’. In this paper we share our experiences of undertaking remote online synchronous focus groups with CYP and discuss how we overcame the challenges associated with conducting qualitative research with CYP ‘from a distance’. We used remote online synchronous focus groups to explore CYP’s perspectives on how education settings can support social, emotional, and mental wellbeing. We reflect on approaches used to uphold rigour and quality, and work ethically and sensitively. We have organised this into five topics reflecting distinct parts of the planning, design and practice: 1) working with CYP as research advisors to shape the design, feasibility and suitability of the methods and approach; 2) developing creative approaches within the online focus groups to increase engagement and inclusion; 3) considering logistical and technical practice; 4) considering ethical practice underpinning online group data collection with CYP; and 5) valuing participation and disseminate findings when working from a distance with participants. We present reflections and guidance for other researchers considering the use of remote online synchronous focus groups with CYP, as a feasible and valuable means for collecting data in both a time- and cost-effective manner.
Determinants of the Decision to Provide Loans to Potential Investors on a Peer-to-Peer Lending Platform

This research aim to reveal a number of possible factor influence investors decisions To do investment in Peer-to-peer (P2P) lending services in Indonesia. Study this use method survey with method distribute questionnaire through googleform to any of the users or a number of service banking . There are 82 questionnaires processed in research this using the PLS smart assistance program . Results in study this prove that Accumulation Transaction and Refund History , as well perception risk take effect to decision gift loan . With evaluate significant factor about party borrower , then potential investors will more easy for differentiate borrower one with others on P2P lending services With a number of factor , got is known that if party borrower could Fulfill all aspect such , then party borrower has give quality signal tall to potential investors. Results of research this expected could add nor expand knowledge knowledge as well as give proof new about a number of factor to be determinant decision gift loans on P2P lending services.
Fracture of a plate under transient thermal stresses

The cracking in a plate of finite thickness due to sudden thermal transient stresses is considered for an edge crack. The elastic strip is assumed to be insulated on one face and cooled suddenly on the face containing the edge crack. Even though the assumption of a step change in temperature on the boundary gives conservative results, it is not a realistic representation of the actual boundary condition. A ramp cooling function is assumed at the boundary, which is more realistic than the assumption of a step function. The inertia effects and the temperature dependence of the elastic constants are negligible. The thermal stresses for the uncracked problem are computed as a function of time. Then, these stresses are used as the crack surface tractions with opposite sign to formulate the mixed boundary value problem. This leads to a singular integral equation of Cauchy-type, which can be solved numerically. The numerical results for the stress intensity factor are computed as a function of the nondimensional.
Economic contribution and integration of Croatian ICT sectors

Despite the numerous benefits of information and communications technology (ICT) in promoting economic growth and sustainable development, its impacts are insufficiently researched. In particular, there have been few attempts to quantity the contribution of ICT sectors to national economies or the level of integration between ICT sectors. In this paper, an alternative model of sector extraction is developed to quantify the importance of ICT sectors in open and closed input--output systems. The proposed model calculates the contribution of ICT sectors to the national gross value added and employment, as well as the cross-sectoral and intra-sectoral deliveries between ICT sectors. The model is applied to study the Croatian ICT sectors in the years 2010 and 2020. The results indicate that the ICT manufacturing industries lag behind ICT service industries in Croatia. The level of integration differs between individual ICT sectors.
Combined Usage of MDK Inhibitor Augments Interferon-γ Anti-Tumor Activity in the SKOV3 Human Ovarian Cancer Cell Line

Ovarian cancer (OC) is a particularly lethal disease due to intratumoral heterogeneity, resistance to traditional chemotherapy, and poor response to targeted therapy and immunotherapy. Interferon-γ (IFN-γ) is an attractive therapeutic cytokine, with positive responses achieved in multiple OC clinical trials. However, clinical application of IFN-γ in OC is still hindered, due to the severe toxicity when used at higher levels, as well as the considerable pro-metastatic adverse effect when used at lower levels. Thus, an effective combined intervention is needed to enhance the anti-tumor efficacy of IFN-γ and to suppress the IFN-γ-induced metastasis. Here, we uncovered that OC cells develop an adaptive strategy by upregulating midkine (MDK) to counteract the IFN-γ-induced anti-tumor activity and to fuel IFN-γ-induced metastasis. We showed that MDK is a critical downstream target of IFN-γ in OC, and that this regulation acts in a dose-dependent manner and is mediated by STAT1. Gain-of-function studies showed that MDK overexpression promotes cell proliferation and metastasis in OC, indicating that IFN-γ-activated MDK may antagonize IFN-γ in inhibiting OC proliferation but synergize IFN-γ in promoting OC metastasis. Subsequently, we assessed the influence of MDK inhibition on IFN-γ-induced anti-proliferation and pro-metastasis effects using an MDK inhibitor (iMDK), and we found that MDK inhibition robustly enhanced IFN-γ-induced growth inhibition (all CIs < 0.1) and reversed IFN-γ-driven epithelial-to-mesenchymal transition (EMT) and metastasis in OC in vitro. Collectively, these data identify an IFN-γ responsive protein, MDK, in counteracting anti-proliferation while endowing the pro-metastatic role of IFN-γ in cancer treatment, and we therefore propose the combined utilization of the MDK inhibitor in IFN-γ-based therapies in future OC treatment.
The complex Wishart distribution and the symmetric group

Let V be the space of (r, r) Hermitian matrices and let Ω be the cone of the positive definite ones. We say that the random variable S, taking its values in Ω, has the complex Wishart distribution γ p,σ if E(exp trace (θ S)) = (det(I r - σθ)) -p , where a and σ -1 - θ are in Ω, and where p = 1, 2,. , r - 1 or p > r - 1. In this paper, we compute all moments of S and S -1 . The techniques involve in particular the use of the irreducible characters of the symmetric group.
Effective Therapeutic Options for Melioidosis: Antibiotics versus Phage Therapy

Melioidosis, also known as Whitmore’s disease, is a potentially fatal infection caused by the Gram-negative bacteria Burkholderia pseudomallei with a mortality rate of 10–50%. The condition is a “glanders-like” illness prevalent in Southeast Asian and Northern Australian regions and can affect humans, animals, and sometimes plants. Melioidosis received the epithet “the great mimicker” owing to its vast spectrum of non-specific clinical manifestations, such as localised abscesses, septicaemia, pneumonia, septic arthritis, osteomyelitis, and encephalomyelitis, which often lead to misdiagnosis and ineffective treatment. To date, antibiotics remain the backbone of melioidosis treatment, which includes intravenous therapy with ceftazidime or meropenem, followed by oral therapy with TMP-SMX or amoxicillin/clavulanic acid and supported by adjunctive treatment. However, bacteria have developed resistance to a series of antibiotics, including clinically significant ones, during treatment. Therefore, phage therapy has gained unprecedented interest and has been proposed as an alternative treatment. Although no effective phage therapy has been published, the findings of experimental phage therapies suggest that the concept could be feasible. This article reviews the benefits and limitations of antibiotics and phage therapy in terms of established regimens, bacterial resistance, host specificity, and biofilm degradation.
Aerodynamic shape optimization for unsteady three-dimensional flows

This paper presents an adjoint method for the optimum shape design of unsteady flows. The goal is to develop a set of discrete unsteady adjoint equations and the corresponding boundary condition for the non-linear frequency domain method. First, this paper presents the complete formulation of the time dependent optimal design problem. Second, we present the non-linear frequency domain adjoint equations for three-dimensional flows. Third, we present results that demonstrate the application of the theory to a three-dimensional wing.
Class of digital integrators and differentiators

A novel class of infinite impulse response digital integrators and differentiators is developed. A class of digital integrators is first derived from a class of numerical integration rules. A class of digital differentiators is then obtained by inverting the transfer functions of the obtained integrators and stabilising the resulting transfer functions together with magnitude compensation if necessary. Simulated annealing is applied to optimise some of the obtained integrators and differentiators.
Agreement and argument realization in Mian discourse

A common assumption about the function of gender agreement in discourse is that it serves referent identification and reference tracking. There is some evidence in favour of this view, and an increasing body of research which finds no foundation for it; this study further supports the latter perspective. It is based on a fully annotated corpus of the Papuan language Mian and uses a noteworthy property of the Mian agreement system: object agreement in transitive verbs is “sporadic”, i.e. it depends on the lexical type of a transitive verb whether it agrees with its object. Therefore we can measure whether speakers of Mian manipulate overt vs. null arguments in discourse to compensate whenever lack of agreement might make argument reference ambiguous. The results clearly show that the proportions of overtly realized objects for agreeing verbs and non-agreeing verbs do not differ significantly, thus lending little support to the claim that gender agreement serves a major function in reference tracking in discourse.
Fresh Pod Yield, Physical and Nutritional Quality Attributes of Common Bean as Influenced by Conventional or Organic Farming Practices

The aim of the current study wat to comparatively assess the impact of different nitrogen (N) fertilization schemes on fresh pod yield and yield quality in either organically or conventionally grown common beans (Phaseolus vulgaris L.). Prior to common bean crop establishment, the experimental field site was cultivated following either organic (a) or conventional (b) farming practices with a winter non-legume crop (Brassica oleracea var. italica) (BR), or (c) with field bean (Vicia faba sp.) destined to serve as a green manure (GM) crop. At the end of the winter cultivation period the broccoli crop residues (BR) and green manure biomass (GM) were incorporated into the soil and the plots that accommodated the treatments (a) and (c) were followed by an organically cultivated common bean crop, while the conventional broccoli crop was followed by a conventionally cropped common bean crop. Additional to the plant residues (BR), sheep manure (SM) at a rate of 40 kg N ha−1 was also applied to the organically treated common beans, while the plots with a conventionally cropped common bean received 75 kg N ha−1. Organic common bean treated with SM + BR produced smaller pods of higher dry matter and bioactive compound content, responses that are correlated with limited soil N availability. No significant variations were observed on yield components and N levels of pods cultivated under organic (SM + GM) and conventional cropping systems. Pod sugar and starch content was not influenced by the different fertilization practices. In conclusion, we have demonstrated that the combined application of SM + GM can be considered as an efficient N-fertilisation strategy for organic crops of common bean, benefiting their nutritional value without compromising yield.
Numerical Simulations of the Microphysics and Electrification of the Weakly Electrified 9 February 1993 TOGA COARE Squall Line: Comparisons with Observations

Abstract A cloud scale model with a 12-class bulk microphysics scheme, including 10 ice phases and a 3D lightning parameterization, was used to investigate the electrical properties of a well-documented tropical squall line from the Tropical Ocean Global Atmosphere Coupled Ocean–Atmosphere Response Experiment (TOGA COARE). Consistent with observations, the simulated maximum updraft speeds across the squall line seldom exceeded 10 m s−1, which was expected given the relatively shallow 30-dBZ echo tops that rarely extended above the top of the mixed-phase layer (−20°C isotherm). Enhanced warm rain processes caused most of the liquid water to precipitate near the gust front at lower levels (below 4 km AGL), which accounted for the small amounts of graupel and cloud water content present in the mixed-phase region and, consequently, for generally weak charging and electrification. Most of the charge present in the squall line was generated within a few storm cells just behind the leading edge of the gust front.
Clinical Effectiveness of Vestibular Shields in Orthodontic Treatment: A Scoping Review

This systematic literature search was performed to determine the clinical effectiveness of vestibular shields (VSs) in children undergoing orthodontic treatment. A comprehensive electronic search was performed in May 2022 using three databases (Medline via PubMed, the Cochrane Central Register of Controlled Trials, and Ovid). The initial screening of articles was based on titles and abstracts. Studies meeting the inclusion criteria were retrieved for the final quality assessment and the methodological qualities were assessed according to the Newcastle-Ottawa Scale and Cochrane risk of bias. The initial search identified 262 publications, of which 15 studies were potentially eligible, with excellent intra-examiner reliability (K = 0.88). A total of five studies were selected for the final analysis, including one randomized controlled trial, three clinical trials, and one cohort study. VS may have potential impacts on orthodontic treatment, lips and dental arches, but further high-quality studies are warranted
Phase‐matched second‐harmonic generation in novel corona poled glass waveguides

Second‐order optical nonlinearity χ(2) is induced in glass films by corona poling. The glass films are fabricated by radio‐frequency sputtering Corning7059 onto Pyrex glass substrates. The values of second‐order nonlinear coefficient d33 of the corona‐poled glass films are estimated to be ∼0.5 pm/V. Using the corona‐poled glass films as a waveguide, phase‐matched second‐harmonic generation has been demonstrated in the glass films for the first time. The origin of the χ(2) is considered to be related to the defects in the glass films.
Small Sample Bias Due to Misspecification in the “Partial Adjustment” and “Adaptive Expectations” Models

Abstract The “partial adjustment” and “adaptive expectations” models are simply special cases of a more general model. This fact has not been commonly recognized by investigators who have used one or the other of these two models in empirical economic research. An examination of the results of small sample experiments shows that the bias in the estimated regression coefficients and the estimated mean lag which occurs when either one of the models is fitted by least squares to data generated by the more general model is quite serious. Also it is found that the spread of the distribution of these estimates is very sensitive to this misspecification. The departures from normality of these distributions are notable for the smallest sample sizes examined, but perhaps less significant in view of the severity of the other problems noted.
Determination of quality properties of Kastamonu pastırma: A dry-cured meat product

Pastırma is a Turkish dried meat product that has been produced for centuries with its unique production technology. It is produced from whole muscle and/or muscles obtained from certain parts of beef and buffalo carcasses. This is the first study dealing with some physicochemical properties of Kastamonu pastırma produced mostly sırt and kuşgömü. Significant differences were determined among the pastırma types in all analyses (P<0.05). Pastırma type significantly affected moisture amount (P<0.05). The average moisture content in the kuşgömü pastırma was determined higher than the sırt pastırma. The total protein amount of all samples was determined over 30%, and it is more valuable in terms of nutrition. However, the salt amount (10% / dry matter) and pH (max. 6.0) in 50% of samples were above the maximum acceptable limit. Also, the water activity values of all samples were above 0.90. TBARS and FFA values of some samples were higher than the values previously determined.
A two weight weak type inequality for fractional integrals

For 1 <p < q < oo, 0 < a < n and w(x), v(x) nonnegative weight functions on R'1 we show that the weak type inequality f( xw(x) dx < A-q If(x)l v(x) dx) holds for allf 0 if and only if f [Ta(XQw)(x)] V(x) I dX p 1B Aw) < cc for all cubes Q in Rn. Here T7 denotes the fractional integral of order a, Ta f(x) f I x y I -'f(y) dy. More generally we can replace Ta by any suitable convolution operator with radial kernel decreasing in I x I .
Identification of Hypertension Risk Factor at Tarowang Village, Takalar, Indonesia

The prevalence of hypertension is increasing in the world and in Indonesia. The disease, known as the silent disease, is experienced by many people, but diagnosed too late. As a result, the impact is much greater, namely death from heart disease and stroke. Lifestyle and food intake are modifiable risk factors for hypertension. In addition, gender, age, and genetic history are risk factors that cannot be changed, but by identifying them, it can increase awareness to avoid other risk factors. This study aimed to identify risk factors for hypertension in Tarowang Village. This research was conducted with a cross-sectional study design, total sample was 116 people chosen by purposive sampling method. Hypertension defined using JNC 7 category and measured by ABN Spectrum Aneroid Sphygmomanometer. The results of this study indicate that the prevalence of hypertension was 18.97%. Age and nutritional status have significant relationship with hypertension (0.004 and 0.021, respectively). The variable consumption of vegetables and fruits, although it did not show a significant relationship, the hypertension proportion was still higher in respondents who did not eat vegetables and fruit every day. Promoting healthy behavior was needed to prevent increasing hypertension prevalence. Implementation from nutrition guidelines such as maintaining weight, increasing fruit and vegetable consumption were important in Tarowang Village.
The interaction of waves with arrays of vertical circular cylinders

The scattering of water waves by an array of N bottom-mounted vertical circular cylinders is solved exactly (under the assumption of linear water wave theory) using the method proposed by Spring & Monkmeyer in 1974. A major simplification to this theory has been found which makes the evaluation of quantities such as the forces on the cylinders much simpler. New formulae are given for the first and mean second-order forces together with one for the free-surface elevation in the vicinity of a particular cylinder. Comparisons are made between the exact results shown here and those generated using the approximate method of McIver & Evans (1984). The behaviour of the forces on the bodies in the long-wave limit is also examined for the special case of two cylinders with equal radii.