Miracle-dz/UniFAR-FTUs huggingface dataset:
Time-averaged Turbulent Flow Characteristics over a Highly Spatially Heterogeneous Gravel-Bed

The present study focuses on the time-averaged turbulence characteristics over a highly spatially-heterogeneous gravel-bed. The timeaveraged streamwise velocity, Reynolds shear and normal stresses, turbulent kinetic energy, higher-order moments of velocity fluctuations, length scales, and the turbulent bursting were measured over a gravel-bed with an array of larger gravels. It was observed that the turbulence characteristics do not vary significantly above the crest level of the array as compared to those below the array. The nondimensional streamwise velocity decreases considerably with a decrease in depth below the array. Below the array, the Reynolds shear stress (RSS) deviates from the gravity- law of RSS distributions. Turbulence intensities reduce below the crest level of the gravel-bed. The third-order moments of velocity fluctuations increase below the crest level of the gravel-bed and give a clear indication of sweeps as the predominating event which were further verified with the quadrant analysis plots. The turbulent length scales values change significantly below the crest level of the gravel-bed.
Deciphering Molecular Mechanisms Involved in the Modulation of Human Aquaporins’ Water Permeability by Zinc Cations: A Molecular Dynamics Approach

Aquaporins (AQPs) constitute a wide family of water channels implicated in all kind of physiological processes. Zinc is the second most abundant trace element in the human body and a few studies have highlighted regulation of AQP0 and AQP4 by zinc. In the present work, we addressed the putative regulation of AQPs by zinc cations in silico through molecular dynamics simulations of human AQP0, AQP2, AQP4, and AQP5. Our results align with other scales of study and several in vitro techniques, hence strengthening the reliability of this regulation by zinc. We also described two distinct putative molecular mechanisms associated with the increase or decrease in AQPs’ water permeability after zinc binding. In association with other studies, our work will help deciphering the interaction networks existing between zinc and channel proteins.
The Relationship between Dynamic Balance, Jumping Ability, and Agility with 100 m Sprinting Performance in Athletes with Intellectual Disabilities

Sprinting is a competitive event in athletics that requires a combination of speed, power, agility, and balance. This study investigated the relationship between dynamic balance, jumping ability, and agility with 100 m sprinting performance in athletes with intellectual disabilities, addressing an underexplored connection. A sample of 27 sprinters with intellectual disabilities participated in this study and completed 100 m sprint and various tests, including the Y Balance Test (YBT), the Crossover hop test, squat jump (SJ), countermovement jump (CMJ), and t-test to evaluate their dynamic balance, jumping ability, and agility, respectively. The findings revealed significant negative correlations between the YBT, Crossover hop test, SJ, and CMJ and 100 m sprint performance (r range: −0.41 to −0.79, p < 0.05). Regression analysis identified these variables as significant predictors (R2 = 0.69; p < 0.01). SJ exhibited the strongest association with 100 m sprint performance, (R2 = 0.62, p < 0.01). The agility t-test did not show a significant association. The combination of the YBT ANT and SJ demonstrated a predictive capability for 100 m sprint performance (R2 = 0.67, p < 0.001). In conclusion, this study revealed predictive capabilities between dynamic balance, jumping ability, and 100 m sprint performance in sprinters with intellectual disabilities.
The Roles of Sales Technologies for Salespeople: Techno Demands and Resources Model Perspective

The purpose of this study is to examine the effects of a salesperson’s techno-demands and techno-resources created by new sales-related information technology on salespersons’ attitudinal and behavioral outcomes such as job burnout, job satisfaction, turnover intention, and sales performance. In order to test the proposed framework, data were collected from 305 salespeople in Korea. The results of a partial least squared structural equation modeling (PLS-SEM) analysis showed that techno-demands have a significant positive effect on salespeople’s job burnout and techno-resources have a significant positive effect on salespeople’s job satisfaction. Salespeople’s job burnout has a significant positive effect on salespeople’s turnover intention, whereas salespeople’s job satisfaction has a significant positive effect on salespeople’s sales performance. Finally, salespeople’s job satisfaction has a negative effect on turnover intention. Theoretically, this study develops a new comprehensive framework of the techno demands–resources model and is empirically tested in the context of salespeople. Managerially, the findings offer important insights to practitioners to leverage techno-resources to accelerate the sales technologies for sales activities.
Organizational Resilience to Knowledge Loss in Biotechnology Research

In this article, we examine organizational resilience to research and development (R&D) productivity losses following knowledge loss (aka “forgetting”) using a long panel (1970–2007) of data on U.S. biotechnology research. In our model, knowledge and R&D productivity loss may occur through three mechanisms, scientist turnover, interference with knowledge retrieval, and scientist knowledge decay. Our model also proposes three means through which organizations may become resilient to the effects of knowledge loss on R&D productivity. First, managers may compensate for knowledge losses due to turnover by recruitment. Second, the effects of interference to knowledge retrieval due to the use of new technologies may be minimized if new technologies are introduced into organizations by members with little prior experience in using incumbent technologies or by scientists with little prior collaboration experience. Third, scientists may mitigate the effects of knowledge decay by relearning because the reacquisition of previously lost knowledge is easier than learning it was initially. Irrespective of their source, our results suggest that the agency plays a role in making an organization resist the negative effects of knowledge loss on its R&D productivity.
Relict basin closure and crustal shortening budgets during continental collision: An example from Caucasus sediment provenance

Comparison of plate convergence with the timing and magnitude of upper crustal shortening in collisional orogens indicates both shortening deficits (200–1700 km) and significant (10–40%) plate deceleration during collision, the cause(s) for which remains debated. The Greater Caucasus Mountains, which result from postcollisional Cenozoic closure of a relict Mesozoic back‐arc basin on the northern margin of the Arabia‐Eurasia collision zone, help reconcile these debates. Here we use U‐Pb detrital zircon provenance data and the regional geology of the Caucasus to investigate the width of the now‐consumed Mesozoic back‐arc basin and its closure history. The provenance data record distinct southern and northern provenance domains that persisted until at least the Miocene. Maximum basin width was likely ~350–400 km. We propose that closure of the back‐arc basin initiated at ~35 Ma, coincident with initial (soft) Arabia‐Eurasia collision along the Bitlis‐Zagros suture, eventually leading to ~5 Ma (hard) collision between the Lesser Caucasus arc and the Scythian platform to form the Greater Caucasus Mountains. Final basin closure triggered deceleration of plate convergence and tectonic reorganization throughout the collision. Postcollisional subduction of such small (102–103 km wide) relict ocean basins can account for both shortening deficits and delays in plate deceleration by accommodating convergence via subduction/underthrusting, although such shortening is easily missed if it occurs along structures hidden within flysch/slate belts. Relict basin closure is likely typical in continental collisions in which the colliding margins are either irregularly shaped or rimmed by extensive back‐arc basins and fringing arcs, such as those in the modern South Pacific.
Evaluation of antimicrobial susceptibility & rapid urine screening tests in asymptomatic urinary tract infection in pregnant women in Karbala May

(K . J . Pharm . Sci) (Received August 2011, Accepted Nov. 2011) Abstract Background: Urinary tract infection is a common source of bacterial infections in human and they considered mutually with anemia and hypertension as the most medical complications during pregnancy ,with observe to the point that most of urinary tract infections are asymptomatic in pregnant women and the incidence rate of asymptomatic urinary tract is about 2-13% during pregnancy, this could lead to serious complications such as prematurity ,low birth weight ,hypertension and higher fetal mortality rates if untreated ; urinalysis is one of the important and useful urological tests for diagnosis of such infections, microscopic examination of urine and the dipstick urinalyses (leukocytes esterase test, nitrite test) are common tests used for detecting bacteriuria and pyuria. Objective: to study the prevalence of asymptomatic bacteriuria by using and evaluation various screening rapid tests of urinalysis, bacterial uropathogens and their antimicrobial susceptibility pattern in pregnant women attending educational hospital for Gynecology and Obstetrics in Kerbela. Patients and Method: In this study (480) pregnant woman their mean age 28.3±4.8 ranges (19-39),( apparently healthy without any signs or symptoms of urinary tract infection were included),attended to educational hospital for Gynecology and Obstetrics in Kerbela during the period (MAR-DEC 2010) were investigated for asymptomatic bacteriuria,all urine samples were collected then submitted for routine urinalysis and bacterial culture, Gram’s stain, dipstick and urine microscopy, antimicrobial susceptibility were done using disc diffusion method . Results: of 480 samples,(27)women (5.6%)showed urine culture results indicating significant bacteriuria, the dominant uropathogens was E.coli 11 (40.71% ,Ciprofloxacin, Gentamicin and Nalidixic acid to be the most effective antibiotics; all isolates showed resistance for Ampicillin, Ciprofloxacin to be the drug of choice to treat UTIs. The Gram’s stain was the most specific (98.8%) and sensitive (92.5%) among the rapid tests that had been used, the sensitivity of leukocytes esterase test was 70.3% higher than nitrite test 66.6%while specificity was88.5% which is lower than nitrite test 97.1%, the positive predictive value and negative predictive value for nitrite test were 58%, 97.9% respectively while for leukocytes esterase test record 26.7%, 98% respectively. The positive predictive value and negative predictive value for Gram’s stain) 83.3%, 99.5%) were higher than that recorded in both nitrite test and leukocytes esterase. Conclusions:
Selection of M5 mutant lines of wheat (Triticum aestivum L.) for agronomic traits and biomass allocation under drought stress and non-stressed conditions

Introduction In the face of climate changes and limited water availability for irrigated crop production, enhanced drought tolerance and adaptation is vital to improve wheat productivity. The objective of this study was to determine the responses of newly bred and advanced mutant lines of wheat based on agronomic traits and biomass allocation under drought-stressed and non-stressed environments for production and breeding. Methods Fifty-three mutant lines, including the parental check and six check varieties, were evaluated under non-stressed (NS) and drought stressed (DS) conditions in the field and controlled environments using a 20 x 3 alpha lattice design with two replicates. The following agronomic data were collected: days to 50% heading (DTH), days to maturity (DTM), plant height (PH), number of productive tillers (PTN), shoot biomass (SB), root biomass (RB), total biomass (TB), root: shoot ratio (RSR), spike length (SL), thousand seeds weight (TSW) and grain yield (GY). Data were analyzed and summarized using various statistical procedures and drought tolerance indices were computed based on grain yield under NS and DS conditions. Results Significant (P < 0.05) differences were recorded among the mutant lines for most assessed traits under NS and DS conditions. Grain yield positively and significantly (p < 0.001) correlated with PTN (r = 0.85), RB (r = 0.75), SB (r = 0.80), SL (r =0.73), TB (r = 0.65), and TSW (r = 0.67) under DS condition. Principal component analysis revealed three components contributing to 78.55% and 77.21% of the total variability for the assessed agronomic traits under DS and NS conditions, respectively. The following traits: GY, RB, SB, and PTN explained most of the variation with high loading scores under DS condition. Geometric mean productivity (GMP), mean productivity (MP), harmonic mean (HM), and stress tolerance index (STI) were identified as the best drought tolerance indices for the identification of tolerant lines with positive correlations with GY under NS and DS conditions. Discussion Among the advanced lines tested, LMA16, LMA37, LMA47, LMA2, and LMA42 were selected as the superior lines with high performance and drought tolerance. The selected lines are recommended for multi-environment trails and release for production in water-limited environments in South Africa.
lncRNA GAPLINC regulates vascular endothelial cell apoptosis in atherosclerosis

Introduction In this study, we investigated the role of the long non-coding RNA GAPLINC in atherosclerosis under oxidized low-density lipoprotein (ox-LDL) treatment. Material and methods We utilized ox-LDL exposed human aortic endothelial cells as an in-vitro model. The expression level of GAPLINC was quantified by qPCR in different times and concentrations of ox-LDL treatment conditions. Cell apoptosis rate and cell cycle profiles were assessed by flow cytometry and TUNEL assay. The target association was confirmed using a luciferase reporter assay and Western blot. Results We found that GAPLINC expression was induced by ox-LDL treatment, but cell proliferation ability was significantly inhibited. We further confirmed that overexpressing of lncRNA GAPLINC in ox-LDL-exposed HAECs decreased cell proliferation by increasing cell apoptosis and arresting cell cycle in G2/M and S phase. Importantly, the detailed mechanistic analysis elucidated that LncRNA GAPLINC acts as a decoy to sequester miR-183-5p to prevent it from binding to target PDCD4. MiR-183-5p targets GAPLINC, and PDCD4 is a downstream target of miR-183-5p, and the cellular effects of this direct interaction were confirmed by a rescue assay experiment. Conclusions The present study demonstrates that upregulation of lncRNA GAPLINC represses the binding of miR-183-5p to the PDCD4 promoter region and then promotes PDCD4 expression, thereby inducing cell apoptosis and suppressing endothelial cell proliferation.
Integrating Artificial Intelligence in Pediatric Healthcare: Parental Perceptions and Ethical Implications

Background: Our study aimed to explore the way artificial intelligence (AI) utilization is perceived in pediatric medicine, examining its acceptance among patients (in this case represented by their adult parents), and identify the challenges it presents in order to understand the factors influencing its adoption in clinical settings. Methods: A structured questionnaire was applied to caregivers (parents or grandparents) of children who presented in tertiary pediatric clinics. Results: The most significant differentiations were identified in relation to the level of education (e.g., aversion to AI involvement was 22.2% among those with postgraduate degrees, 43.9% among those with university degrees, and 54.5% among those who only completed high school). The greatest fear among respondents regarding the medical use of AI was related to the possibility of errors occurring (70.1%). Conclusions: The general attitude toward the use of AI can be considered positive, provided that it remains human-supervised, and that the technology used is explained in detail by the physician. However, there were large differences among groups (mainly defined by education level) in the way AI is perceived and accepted.
TCF 7l2 Gene Variant Rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Secretion

Type 2 diabetes is a complex metabolic disorder with both genetic and environmental factors such as food habits and lifestyle contributing to its pathogenesis [1] . Due to its complex aetiology, the progress of discovery of genetic components for Type 2 diabetes had been very slow until the advent of high throughput genome-wide association (GWA) studies [2][3] . Most individuals with T2DM suffer serious complications of chronic hyperglycemia, involved in nephropathy, neuropathy, retinopathy, and accelerated development of cardiovascular disease. When the micro vascular complications are related to the degree of fasting hyperglycemia [4] , macro vascular complication like atherosclerosis is related to postprandial glycemic level [5] . One of the regulators of postprandial glucose level is GLP-1.
Guidelines for sampling bedload transport with minimum uncertainty

The stability of river channels and their suitability as habitat for aqueous organisms is strongly controlled by the rate of bedload transport. Quantification of bedload transport rates in rivers is difficult, not only because of the temporal variation in transport, but also because of the cross‐channel variation in transport. The objectives of this study were: (i) to determine the effect of cross‐channel variation in bedload transport on the uncertainty of width‐integrated transport rates; and to use this knowledge (ii) to improve guidelines for bedload sampling. This was done through a thorough statistical evaluation of stochastic and systematic uncertainties involved in bed‐load transport measurements. Based on this evaluation, new guidelines are presented for determination of the number of samples and sampling positions across the channel that are required for bedload measurements in several types of sand‐bed rivers and gravel‐bed rivers. The guidelines relate to bedload measurements made with pressure‐difference (Helley‐Smith type) samplers that require numerous bedload samples of short duration at several positions across the channel. The results show that generally more sampling positions across the channel are required in gravel‐bed rivers than in sand‐bed rivers. For gravel‐bed rivers with unknown cross‐channel distribution of transport, at least 10 sampling positions are recommended, whereas for most sand‐bed rivers five positions suffice. In addition, at least 12 short‐duration samples are required at each position to obtain bedload estimates with uncertainties below 20%. If the same level of uncertainty is desired in the case of high spatial and temporal variation in transport rates, the number of short‐duration samples needed per sampling position increases to 40.
Palaeoproterozoic evolution of the Lewisian complex of the Outer Hebrides, Northwest Scotland : the South Harris complex, a possible accreted island arc?

The Palaeoproterozoic evolution of the central Outer Hebrides can be explained by modem plate-tectonic processes and is consistent with the products of a Wilson cycle. Local continental crust comprising c. 2.8 Ga tonalitic orthogneiss underwent extension and rifting leading to the deposition of clastic sediments derived from a late Archaean source, and was followed by the emplacement of c. 2 Ga mafic dykes. The latter are probably not directly equivalent to the Scourie dykes of the Scottish mainland. Rupturing and the formation of an ocean basin followed, and this was subsequently subducted around 1.9 Ga leading to the development of a volcanic arc, which now forms much, but not all of the South Harris Complex. This arc was founded on continental crust formed in part by the c. 2.5 Ga South Harris anorthosite. During subsequent collision events the late Archaean tonalitic gneisses and enclosed dykes were sutured back together trapping arc and probable ophiolitic material in the process. The latter is concentrated in a major imbricate zone lying immediately NE of the arc rocks, and formed by the Langavat Belt. In addition to probable ophiolitic material, this zone includes Archaean-derived metasediments, and slivers of Archaean basement gneiss. This represents the most probable location of the major suture zone associated with the reassembly of the Archaean gneisses. Suturing was followed by the initiation of kilometre scale post-collisional shear zones. One of these, the Langavat Shear Zone was initiated prior to -1740 Ma, and exploits the Langavat Belt imbricate zone. The evolution of the Lewisian Complex of the Outer Hebrides is closely comparable to the Nagssugtoqidian orogen of southern Greenland, with which it is correlated. In fact, the geology of the Outer Hebrides bears a closer affinity with the Nagssugtoqidian belt than it does to the Lewisian rocks of the Scottish mainland.
Evaluation of The Tolerance Levels of 35 Cacao Genotypes to Dry Periods

A prolong dry periods could have a negative impact on growth and yield of cocoa. Th e objectives of this study were to evaluate the tolerance level s of 35 cocoa genotypes to dry periods. The study was conducted at the Pakuwon Experimental Station, Indonesian Industrial and Beverages Crops Research Institute, Sukabumi, West Java; 450 m above sea level; Latosol soil type; and B type of climate; started from August 2014 until October 2015. Thirty five cacao genotypes consisted of two released variety (i.e Sulawesi 1 and SCA 6) and 33 other genotypes were used in this research. The cacao plants were three-years old, cultivated at a 3 x 3 m spacing distance under the 26 years old Salak Dwarf coconut trees. Ten plant sample s were determined randomly and the fruits were harves t ed in February 2015 (wet period) and October 2015 (dry period). A bulk of 10–30 pods per genotype were randomly selected for each harvest periods. The variable observed were fresh weigth per pod, number of beans per pod, fresh and dry weight of beans per pod, and fresh weight of pod husks + pulps per pod. The tolerance level to dry periods was determined base on the dry weight of bean/pod. The result showed that a continueous six months dry periods prior to harvesting significantly reduced yield components from 4.92%-42.54%. Based on the dry weight of beans per pod, three genotypes, namely KW 162, KW 165, and KW 215, were classified as tolerant, while the other were moderately tolerant and susceptible to drought. Th e result implie s the important of further research to obtain superior cocoa clones resistance to drought.