Miracle-dz/UniFAR-FTUs huggingface dataset:
Beta 2-Adrenergic Receptor in Circulating Cancer-Associated Cells Predicts for Increases in Stromal Macrophages in Circulation and Patient Survival in Metastatic Breast Cancer

The usage of beta blockers in breast cancer (BC) patients is implicated in the reduction in distant metastases, cancer recurrence, and cancer mortality. Studies suggest that the adrenergic pathway is directly involved in sympathetic-driven hematopoietic activation of pro-tumor microenvironmental proliferation and tumor cell trafficking into the circulation. Cancer-associated macrophage-like cells (CAMLs) are pro-tumor polynucleated monocytic cells of hematopoietic origin emanating from tumors which may aid in circulating tumor cell (CTC) dissemination into the circulation. We examined the linkage between Beta-2 adrenergic receptor (B2AR) signaling in CAMLs and CTCs by establishing expression profiles in a model BC cell line (MDA-MB-231). We compared the model to CAMLs and CTCs found in patents. Although internalization events were observed in patients, differences were found in the expression of B2AR between the tumor cell lines and the CAMLs found in patients. High B2AR expression on patients’ CAMLs was correlated with significantly more CAMLs in the circulation (p = 0.0093), but CTCs had no numerical relationship (p = 0.1565). High B2AR CAML expression was also significantly associated with a larger size of CAMLs (p = 0.0073), as well as being significantly associated with shorter progression-free survival (p = 0.0097) and overall survival (p = 0.0265). These data suggest that B2AR expression on CAMLs is closely related to the activation, intravasation, and growth of CAMLs in the circulation.
Implementation and impact on length of stay of a post-discharge remote patient monitoring program for acutely hospitalized COVID-19 pneumonia patients

Abstract Objective In order to manage COVID-19 patient population and bed capacity issues, remote patient monitoring (RPM) is a strategy used to transition patients from inpatients to home. We describe our RPM implementation process for post-acute care COVID-19 pneumonia patients. We also evaluate the impact of RPM on patient outcomes, including hospital length of stay (LOS), post-discharge Emergency Department (ED) visits, and hospital readmission. Materials and Methods We utilized a cloud-based RPM platform (Vivify Health) and a nurse-monitoring service (Global Medical Response) to enroll COVID-19 patients who required oxygen supplementation after hospital discharge. We evaluated patient participation, biometric alerts, and provider communication. We also assessed the program’s impact by comparing RPM patient outcomes with a retrospective cohort of Control patients who similarly required oxygen supplementation after discharge but were not referred to the RPM program. Statistical analyses were performed to evaluate the 2 groups’ demographic characteristics, hospital LOS, and readmission rates. Results The RPM program enrolled 75 patients with respondents of a post-participation survey reporting high satisfaction with the program. Compared to the Control group (n = 150), which had similar demographics and baseline characteristics, the RPM group was associated with shorter hospital LOS (median 4.8 vs 6.1 days; P=.03) without adversely impacting return to the ED or readmission. Conclusion We implemented a RPM program for post-acute discharged COVID-19 patients requiring oxygen supplementation. Our RPM program resulted in a shorter hospital LOS without adversely impacting quality outcomes for readmission rates and improved healthcare utilization by reducing the average LOS.
Metabolism-Related Gene Expression in Circulating Tumor Cells from Patients with Early Stage Non-Small Cell Lung Cancer

Simple Summary In the present study, the expression of three Metabolism-Related Enzymes (MRGs) that are related to glucose and pyruvate metabolism, in parallel with glucose and monocarboxylate transporter expression (HK2, MCT1, PHGDH), was studied in CTCs isolated from the peripheral blood of early stage NSCLC patients at different timepoints. The expression levels of all tested MRGs decreased in CTCs one month after surgery, but a significant increase was noticed at the time of relapse for PHGDH and MCT1 only. An overexpression of MRGs was observed at a high frequency in the CTCs isolated from early NSCLC patients, thereby supporting the role of MRGs in metastatic processes. The glycolytic and mesenchymal subpopulation of CTCs was significantly predominant compared to CTCs that wereglycolytic but not mesenchymal-like. Our data indicate that MRGs merit further evaluation through large and well-defined cohort studies. Abstract Purpose: Metabolic reprogramming is now characterized as one of the core hallmarks of cancer, and it has already been shown that the altered genomic profile of metabolically rewired cancer cells can give valuable information. In this study, we quantified three Metabolism-Related Gene (MRG) transcripts in the circulating tumor cells (CTCs) of early stage NSCLC patients and evaluated their associations with epithelial and EMT markers. Experimental Design: We first developed and analytically validated highly sensitive RT-qPCR assays for the quantification of HK2, MCT1 and PHGDH transcripts, and further studied the expression of MRGs in CTCs that were isolated using a size-dependent microfluidic device (Parsortix, Angle) from the peripheral blood of: (a) 46 NSCLC patients at baseline, (b) 39/46 of these patients one month after surgery, (c) 10/46 patients at relapse and (d) 10 pairs of cancerous and adjacent non-cancerous FFPE tissues from the same NSCLC patients. Epithelial and EMT markers were also evaluated. Results: MCT1 and HK2 were differentially expressed between HD and NSCLC patients. An overexpression of MCT1 was detected in 15/46 (32.6%) and 3/10 (30%) patients at baseline and at progression disease (PD), respectively, whereas an overexpression of HK2 was detected in 30.4% and 0% of CTCs in the same group of samples. The expression levels of all tested MRGs decreased in CTCs one month after surgery, but a significant increase was noticed at the time of relapse for PHGDH and MCT1 only. The expression levels of HK2 and MCT1 were associated with the overexpression of mesenchymal markers (TWIST-1 and VIM). Conclusion: An overexpression of MRGs was observed at a high frequency in the CTCs isolated from early NSCLC patients, thereby supporting the role of MRGs in metastatic processes. The glycolytic and mesenchymal subpopulation of CTCs was significantly predominant compared to CTCs that were glycolytic but not mesenchymal-like. Our data indicate that MRGs merit further evaluation through large and well-defined cohort studies.
Workshop: Implementing Cloud Collaboration using Fusion 360 into a First-Year Engineering Design Course

Industry and the world at large is becoming an everconnected state where there is greater importance on atypical collaboration. The type of collaboration needed is radical in nature. Radical collaboration for a first-year engineering education curriculum needs to focus on effective learning strategies. This type of collaboration includes timely intervention by instructors, ease of learning for students, and access to professional level tool sets. All of which can create a platform for more engaging and effective peer-to-peer collaboration among students from different branches of engineering, design, and business. Cloud collaboration is a way for distributed, virtual teams to work efficiently on a common project. This workshop will teach faculty the benefits of cloud collaboration using an Autodesk Inc. product, Fusion 360, and the collaborative systems embedded within the platform. The workshop will entail four elements: (1) PreWorkshop Signup/Team Formation, (2) A Case Study, (3) Interactive Design Session, and (4) Question and Answer segment. The goal of the workshop is for faculty to feel excited and empowered to implement new technology into their engineering design projects and have students who are novice in 3D modeling increase their skills dramatically. Faculty will leave with a handbook guiding them through the process of utilizing Fusion 360 in their design-based courses with examples. Index Terms – engineering design education, first-year engineering, radical collaboration, technology
Determinants of Trust and Its Impact on Satisfaction of Halal Cosmetic Products Consumers

: The Covid-19 pandemic has impacted spending on halal products, including beauty and cosmetic products, because many consumers are forced to live and work from home. This study aims to analyze the determinants of consumer trust from factors of religiosity, brand image, and perceived value and their impact on consumer satisfaction with halal cosmetic products. The population of this study is the female population in Jakarta and South Tangerangaged 15-60 years. Research samples 210 respondents using the purposive sampling technique. Data were collected using questionnaires and analyzed using Partial Least Square (PLS) analysis method. The results showed that religiosity has insignificant and positive effect on consumer trust in halal cosmetic products, brand image and perceived value havesignificant and positiveeffect on consumer trust in halal cosmetic products. Consumer trust has significant and positive effect on consumer satisfaction with halal cosmetic products.
Adjunctive Preoperative Ranibizumab (Luecentis) Before Vitrectomy for Vitreous Haemorrhage in Diabetics

Background: When proliferative diabetic retinopathy is treated with pars plana vitrectomy, post-operative vitreous bleeding is prevalent. Complications such as these impede visual rehabilitation and may demand additional surgical treatments. Aim of The Work: An evaluation of efficacy as well as safety of intravitreal ranibizumab prior to Vitrectomy surgery in individuals with diabetes to reduce postoperative bleeding. Patients and Methods: More than one month of persistent diabetic vitreous bleeding was included in this randomized, prospective research. There were two groups of eyes that were considered eligible: Twenty eyes in Group A had no intravitreal injections, while twenty eyes in Group B received a ranibizumab intraoperative intravitreal injection. Results: PDR problems are related with considerable improvement in postoperative BCVA in one week, one month, and three months postoperatively in both group A and group B compared to preoperative BCVA. Postoperative BCVA at 3 months which was 0.953± 0.451 and A statistically significant difference (p = 0.000) was found between the two groups. Conclusion: In patients who got preoperative intravitreal ranibizumab injection, the incidence of postoperative vitreous hemorrhage is lower than in individuals who did not receive IVR injection. There was no statistical significance despite this association, however this is because there were only a few cases in this study.
Detection of Campylobacter fetus in aborted ewes in Sulaimani province by PCR

Abortion is one of the most critical factors affecting lambing rates and, as a result, sheep farm profitability. It is also significant from a zoonotic viewpoint, in addition to financial losses. In sheep flocks, Campylobacter fetus causes infectious infertility, embryonic death, and miscarriages. The study investigated C. fetus from aborted fetuses and vaginal swab samples collected from sheep flocks in the Sulaimani province by the polymerase chain reaction. Thirty-eight aborted fetuses and 70 vaginal swabs were collected from sheep flocks in three districts of Sulaimani province (Kalar, Said Sadiq, and Chamchamal) from March 2018 to June 2019. The pathogen was identified in clinical specimens using conventional PCR. C. fetus was isolated in 16 of 38 aborted fetuses 42.1% and 13 of 70 vaginal swabs from aborted ewes 18.6%. The C. fetus gene 16S rRNA was sequenced and received the accession number MW694741 in NCBI GenBank. Phylogenetic analysis of 16S rRNA gene sequences designated that the C. fetus isolates formed a separate branch displayed the highest similarity and clustered with MN203686.1 and EU773268.1 accessions in a specific clade. A lower degree of affinity of C. fetus was revealed with Campylobacter coli and Campylobacter jejuni .
A prospective cohort study to assess the clinical profile of acute appendicitis and evaluate the combined use of modified Alvarado score and ultrasonography in a tertiary care center in India

Background: Acute appendicitis is one of the most common causes of acute abdomen presentation to the hospital. If not treated in time, it may lead to perforation. Alvarado score is a clinical scoring system used in the diagnosis of acute appendicitis. The score is based on laboratory findings, clinical symptoms, and signs. We stipulate that ultrasonography and modified Alvarado score (MAS) can be synchronously and concomitantly be used to reach a trustable diagnosis of acute appendicitis. Aims and Objectives: The aims of this study were to assess the clinical profile of acute appendicitis and evaluate the combined use of MAS and ultrasonography (USG) in a tertiary care center in India. Materials and Methods: This is a prospective observational study, in which a cohort of patients presenting with acute abdomen due to acute appendicitis to the department of general surgery (Out Patient Department and Emergency) of L.L. R. Hospital attached to G.S. V.M. Medical College, Kanpur and meeting specific inclusion criteria were sampled between October 2021 and January 2022. Results: Our study re-enforces and supports demographic findings of prevalence as well as clinical findings reported in the previous studies on acute appendicitis. Conclusion: CECT of the abdomen can prove to be financially straining for people seeking treatment at public health care centers in developing or underdeveloped countries. Our study suggests that USG can be concomitantly and synchronously be used with MAS to reach a trustable diagnosis without the need for a CECT of the abdomen.
Combining ability and heterosis for yield contributing and fibre quality traits in the hybrids of Gossypium hirsutum L.

The present study was investigated in thirty five hybrids of Gossypium hirsutum L. for combining ability and heterosis for ten yield and fibre contributing traits. These hybrids were obtained by the crosses made between seven lines and five testers. None of the crosses was superior for all the traits studied for the mean performance. The hybrid TCH 1199 × GTHV 323 showed the highest mid and better parent heterosis for the lint index and the hybrid TCH 1828 × RHC 1409 exhibited the highest significant mid and better parent heterosis for ginning outturn. The characters viz., boll weight and single cotton yield per plant were identified to have the highest significant mid and better parent values in the hybrid BSH 18 × RHC 1409. For yield contributing traits viz., the number of sympodial branches per plant and the number of bolls per plant out numbered in the hybrid CO 14 × KC 3 with the maximum standard heterosis among the thirty five hybrids. Combining ability analysis exhibits the dominance of non- additive gene action in all yield and fibre quality contributing traits. Among the lines CO 14 and TCH 1828 were estimated as the best combiners for yield and quality traits, respectively. Among the testers, KC 2 and KC 3 were found to be the best among all the five testers. The hybrid BSH 18× RHC 1409 exhibited the highest sca for the boll weight and seed cotton yield per plant and the hybrid BSH 18 × GISV 323 exhibited the highest sca for the quality traits viz . , ginning out turn and upper half mean length; TCH 1828 × KC 3 and CO 14 × KC 2 best performed hybrids for sca values for the quality traits viz., elongation length and micronaire values.
Comparative Histological Assessment of Osseodensification Implant Site Preparation Versus Conventional Drilling Technique

Purpose: is to analyze histologically in a dog model how osseodensification (OD) implant site preparation method influence the bone area fraction (BAF), the bone implant contact (BIC) and bone mineral density (BMD) around dental implants compared to the conventional drilling method. Materials and Methods: this experimental study was conducted on four dogs using split mouth fashion so that each side received two implants with two different implant-site preparation technique. In the study group, Densah Burs were used to osseodensify the osteotomy site where conventional cutting drills were used in the control group. Light Microscope (LM) examination of HE-stained sections was used to evaluate BAF, while Scanning Electron Microscope (SEM) was used to evaluate BIC and BMD. Results: osseointegration was almost similar in the control and experimental groups examined by both LM and SEM. There was no statistically
The role of social networks and mobile applications in physical activity during the COVID-19 epidemic in Serbia

After the outbreak of the novel SARS-COV-2 coronavirus, in the Chinese province of Wuhan that spread rapidly across the world, the Government of the Republic of Serbia introduced protection measures in March 2020, to prevent the spread of the infectious disease COVID-19 in Serbia. All gatherings indoors (sport, cultural and other events), as well as in parks and public places intended for recreation and sports, were prohibited. Shortly after, a lockdown took place which prohibited leaving home with the exception of basic needs, work from home was recommended and online schooling was introduced. The World Health Organization has recommended the use of online resources to maintain basic physical activity. In these circumstances of social distancing, this study examines the prevalence of physical activity supported by social networks and mobile applications during the COVID-19 lockdown in Serbia. The study was conducted as a cross-sectional study, using questionnaire distributed through social networks. The study found that more than a third of respondents (38.3%) used social networks or mobile apps to perform physical activity during the lockdown in Serbia; 27.1% used social networks/mobile apps before the pandemic, while 11.2% began to use social networks/mobile apps to perform physical activity during the lockdown. Easy access and review of exercises were the most common reasons for using social networks/mobile apps. 40% of the participants in the study agreed that social networks/mobile apps, make it easier to engage in physical activity. Based on the presented results, it can be concluded that the promotion of physical activity at home through social networks and mobile apps can provide an invaluable contribution to maintaining physical activity globally during pandemics such as COVID-19.
Including equity in urban stream restoration: From historical wrongs to new paradigms

As the practice of stream restoration continues expanding globally, the importance of including social factors and communities within the restoration or revitalization process also increases. Engineers and environmental scientists have acknowledged the crucial role of actively involving such communities, but community involvement poses challenges because there is little guidance on managing social processes and balancing different interests. Although many restoration efforts appear to be addressing the needs of crucial ecological habitats, there have been concerning disparities identified associated to race, ethnicity, and income. Through examining 2 case studies, we attempt to identify historical trends and to describe inequities, environmental burdens, and urgent needs of oppressed communities. This validation process also led us to explore systemic constraints that can perpetuate injustices. We suggest that an equity and environmental justice perspective can provide both context and an opportunity to recognize and address basic needs of communities. The ultimate goal of stream restoration should be to achieve solutions that provide true justice; therefore, considering power relations and finding causes rather than symptoms of inequities are both important to achieving more sustainable and equitable stream restoration outcomes.
Schopenhauer's Pessimism: The Trial of Existence

I attempt to present a more holistic and more detailed account of Schopenhauer's pessimistic philosophical premises and their implications. The discussion begins with Schopenhauer's claim that the world is representation and with the discovering of the Will. It continues by examining the implications of the Will, which leads to the argument against existence itself.
Exploring the Immigrant Entrepreneurs and Their Entrepreneurial Engagement

This study explores how immigrants perceive their entrepreneurial selves and their strategies to find opportunities when migrating to a new country. It focuses on their journey to find these opportunities and their experiences from the endeavour. Thus, it focuses on the conditions of immigrant entrepreneurs and their experiences by capturing entrepreneurs’ experiences across different phases of their entrepreneurial endeavours. The article addresses the recent surge in the entrepreneurship literature focusing on immigrant entrepreneurship, including its consequences for integration, job creation possibilities and relationship to the national economy. Findings show that immigrant entrepreneurs adopt a multi-strategy opportunity approach during the early phase that then influences their self-image. Furthermore, for the immigrant entrepreneurs included in this study, identifying and capturing these business opportunities become as important as how they perceive themselves. In addition, the immigrant entrepreneurs’ affective motivation served as an essential mechanism leading their strong self-image towards their aspirational goals. In addition, their descriptions indicate that most of them chose to start their ventures out of passion and enthusiasm rather than out of necessity.