Miracle-dz/UniFAR-FTUs huggingface dataset:
Association Between Severity of COVID-19 Respiratory Disease and Risk of Obstructive Sleep Apnea

Objectives: The purpose of this observational retrospective study was to evaluate, in patients with a severe acute respiratory syndrome coronavirus 2 infection, the association between the severity of coronavirus disease 2019 (COVID-19) respiratory illness and the risk of infected patients to develop obstructive sleep apnea (OSA). Methods: Ninety-six patients with confirmed COVID-19 infection were enrolled in the study. The STOP-BANG questionnaire to investigate the risk of the OSA syndrome was filled in by the patients at admission. The enrolled patients were divided into 2 groups according to the respiratory disease: group 1 (72 patients), hospitalized patients undergoing conventional oxygen therapy; group 2 (24 patients), patients requiring enhanced respiratory support. STOP-BANG results of these 2 groups were compared to observe whether patients with high OSA risk more frequently presented a severe form of COVID-19. Results: 41.6% of the patients in group 2 had a STOP-BANG score between 5 and 8 (high risk of having apnea); in contrast, 20.8% of the patients in group 1 had a STOP-BANG score between 5 and 8, with a statistically significant difference between the 2 groups (P = .05). A complementary trend was observed regarding the proportion of patients in the range 0 to 2, which classifies patients at a low risk of OSA (48.6% vs 20.8% for groups 1 and 2, P = .01). Conclusions: According to our data, the chances of having a severe case of COVID-19 should be considered in patients at high risk of OSA. Current Knowledge/Study Rationale: Emerging research suggests that OSA could represent a potentially important risk factor for the severe forms of COVID-19. The purpose of this observational retrospective study was to evaluate the potential association between OSA and the severity of COVID-19 disease. Study Impact: According to our data, the likelihood of contracting a severe form of COVID-19 disease should be considered in patients at high risk of OSA.
Dual-Energy CT-Derived Electron Density for Diagnosing Metastatic Mediastinal Lymph Nodes in Non-Small Cell Lung Cancer: Comparison With Conventional CT and FDG PET/CT Findings.

Background: Accurate nodal staging is essential to guide treatment selection in patients with non-small cell lung cancer (NSCLC). To our knowledge, measurement of electron density (ED) using dual-energy CT (DECT) is unexplored for this purpose. Objective: To assess the utility of ED from DECT in diagnosing metastatic mediastinal lymph nodes in patients with NSCLC, in comparison with conventional CT and FDG PET/CT. Methods: This retrospective study included 57 patients (36 men, 21 women; mean age 68.4±8.9 years) with NSCLC and surgically resected mediastinal lymph nodes who underwent preoperative DECT and FDG PET/CT. The patients had a total of 117 resected mediastinal lymph nodes (33 metastatic, 84 nonmetastatic). Two radiologists independently reviewed nodes' morphologic features on the 120 kVp images and also measured nodes' iodine concentration (IC) and ED using maps generated from DECT data; consensus was reached for discrepancies. Two separate radiologists assessed FDG PET/CT examinations in consensus for positive node uptake. Diagnostic performance was evaluated for individual and pairwise combinations of features. Results: The sensitivity, specificity, and accuracy for nodal metastasis were 15.2%, 98.8%, and 75.2% for presence of necrosis; 54.5%, 85.7%, and 76.9% for short-axis diameter >8.5 mm; 63.6%, 73.8%, and 70.9% for long-axis diameter >13.0 mm; 51.5%, 79.8%, and 71.8% for attenuation on 120 kVp images ≤95.8 HU; 87.9%, 58.3%, and 66.7% for ED ≤3.48×1023/cm3; and 66.7%, 75.0%, and 72.6% for positive FDG uptake, respectively. Among pairwise combinations of features, accuracy was highest for the combination of ED and short-axis diameter (accuracy 82.9%, sensitivity 54.5%, specificity 94.0%) and the combination of ED and positive FDG uptake (accuracy 82.1%, sensitivity 60.6%, specificity 90.5%); these accuracies were greater than for the individual features (p<.05). Remaining combinations exhibited accuracies ranging from 74.4% to 77.8%. Interobserver agreement analysis demonstrated intraclass correlation coefficient of 0.90 for ED. IC was not significantly different between metastatic and nonmetastatic nodes (p=.18) and was excluded from the diagnostic performance analysis. Conclusion: ED derived from DECT may help diagnose metastatic lymph nodes in NSCLC given decreased ED in metastatic nodes. Clinical Impact: ED may complement conventional CT findings and FDG uptake on PET/CT in diagnosing metastatic nodes.
Activation of cAMP‐dependent phosphorylation pathways is independent of ROS production during mouse sperm capacitation

Mammalian sperm have to undergo capacitation to fertilize the egg. At the molecular level, capacitation involves cAMP synthesis, protein kinase A activation, and downstream increase in tyrosine phosphorylation. In addition, during capacitation, mammalian sperm actively generate reactive oxygen species (ROS). It has been proposed that ROS modulate phosphorylation pathways; however, the crosstalk between these signaling processes is not well‐understood. In the present study, we used loss‐ and gain‐of‐function approaches to evaluate the interconnection between ROS and phosphorylation. We showed that BSA and HCO3−, but not Ca2+, in the capacitation media are required for ROS production. The synergic effect of these compounds was neither mediated by HCO3− stimulation of cAMP synthesis nor by BSA‐induced cholesterol efflux. The capacitation‐induced ROS generation was blocked in the presence of superoxide dismutase (SOD), catalase, and apocynin. However, none of these compounds affected cAMP‐dependent or tyrosine phosphorylation. On the other hand, the addition of NADPH to the media induced ROS generation in sperm incubated in the absence of BSA and HCO3− without upregulating cAMP‐dependent or tyrosine phosphorylation signaling. Most interestingly, catalase, but not SOD, blocked in vitro fertilization suggesting a role for H2O2 in this process.
COVID-19 severity and mortality in multiple sclerosis are not associated with immunotherapy: Insights from a nation-wide Austrian registry

Background The COVID-19 pandemic challenges neurologists in counselling patients with multiple sclerosis (pwMS) regarding their risk by SARS-CoV-2 and in guiding disease-modifying treatment (DMT). Objective To characterize the prevalence and outcome of COVID-19 in pwMS specifically associated with different DMT in a nationwide population-based study. Methods We included patients aged ≥18 years with a confirmed diagnosis of MS and a diagnosis of COVID-19 established between January 1, 2020 and December 31, 2020. We classified COVID-19 course as either mild, severe or fatal. Impact of DMT and specifically immunosuppressants (alemtuzumab, cladribine, fingolimod, ocrelizumab or rituximab) on COVID-19 outcome was determined by multivariable models, adjusted for a-priori-risk. Results Of 126 MS patients with COVID-19 (mean age 43.2 years [SD 13.4], 71% female), 86.5% had a mild course, 9.5% a severe course and 3.2% died from COVID-19. A-priori-risk significantly predicted COVID-19 severity (R2 0.814; p<0.001) and mortality (R2 0.664; p<0.001). Adjusting for this a-priori-risk, neither exposure to any DMT nor exposure to specific immunosuppressive DMT were significantly associated with COVID-19 severity (odds ratio [OR] 1.6; p = 0.667 and OR 1.9; p = 0.426) or mortality (OR 0.5; p = 0.711 and 2.1; 0.233) when compared to no DMT. Conclusions In a population-based MS cohort, COVID-19 outcome was not associated with exposure to DMT and immunosuppressive DMT when accounting for other already known risk factors. This provides reassuring evidence that COVID-19 risk can be individually anticipated in MS and–except for a very small proportion of high-risk patients–treatment decisions should be primarily focused on treating MS rather than the pandemic.
Anatomy education for medical students in the United Kingdom and Republic of Ireland in 2019: A 20‐year follow‐up

Anatomical education in the United Kingdom (UK) and Ireland has long been under scrutiny, especially since the reforms triggered in 1993 by the General Medical Council's “Tomorrow's Doctors. ” The aim of the current study was to investigate the state of medical student anatomy education in the UK and Ireland in 2019. In all, 39 medical schools completed the survey (100% response rate) and trained 10,093 medical students per year cohort. The teachers comprised 760 individuals, of these 143 were employed on full‐time teaching contracts and 103 were employed on education and research contracts. Since a previous survey in 1999, the number of part‐time staff has increased by 300%, including a significant increase in the number of anatomy demonstrators. In 2019, anatomy was predominantly taught to medical students in either a system‐based or hybrid curriculum. In all, 34 medical schools (87%) used human cadavers to teach anatomy, with a total of 1,363 donors being used per annum. Gross anatomy teaching was integrated with medical imaging in 95% of medical schools, embryology in 81%, living anatomy in 78%, neuroanatomy in 73%, and histology in 68.3%. Throughout their five years of study, medical students are allocated on average 85 h of taught time for gross anatomy, 24 h for neuroanatomy, 24 h for histology, 11 h for living anatomy, and 10 for embryology. In the past 20 years, there has been an average loss of 39 h dedicated to gross anatomy teaching and a reduction in time dedicated to all other anatomy sub‐disciplines.
Comparison of the Differences Between Web-Based and Traditional Questionnaire Surveys in Pediatrics: Comparative Survey Study

Background A web-based survey is a novel method for data capture. Some studies have applied web-based surveys in pediatrics, but few of them have reported data on the differences between web-based and traditional questionnaire surveys. Objective The objective of our study was to evaluate the internal consistency of a web-based survey and compare it with a traditional questionnaire survey in pediatrics. Methods A convenience sample of caregivers was invited to participate in the survey on feeding patterns and their children’s eating behaviors if their children were aged 2 to 7 years. A web-based survey and a traditional questionnaire survey were carried out between October 2018 and July 2019. A total of 1085 caregivers were involved in this study, and they were divided into the following three groups based on methods and sources: (1) web-based survey from a web source, (2) web-based survey from a hospital source, and (3) traditional questionnaire survey from a hospital source. The data were then compared and analyzed. Results A total of 735 caregivers participated in the web-based survey and 350 caregivers participated in the traditional questionnaire survey, and 816 cases were then included in the analyses after data processing. The effective rate of the web-based survey was 70.1% (515/735), and the completeness rate of the traditional questionnaire survey was 86.0% (301/350). There were no significant differences between web-based surveys from different sources. However, demographic characteristics were significantly different between the web-based and traditional questionnaire surveys, mainly in terms of age and caregivers (χ²4=16.509, P=.002 and χ²4=111.464, P<.001, respectively). Caregivers of children aged 2 to 3 years and grandparents were more likely to respond to the web-based survey. Age-specific stratified analysis showed that the score of “monitoring” and the reporting rate of “poor appetite” in children aged 2 to 3 years were significantly higher in the web-based survey compared to the traditional questionnaire survey after adjusting for demographic characteristics. Conclusions A web-based survey could be a feasible tool in pediatric studies. However, differences in demographic characteristics and their possible impacts on the results should be considered in the analyses.
Physicochemical properties of apple seed and its oil

In order to research and exploit apple seed resource,the main nutritional ingredients and physicochemical parameter of apple seed and oil were analyzed.The apple seed contains 27． 7 % oil,in which the content of unsaturated fatty acid is over 89． 33%,34． 0% protein,10． 2% moisture and trace elements.The physicochemical parameters of the oil are as follows:n~(20) 1． 4734, d_4~(20) 0． 9219,Ⅳ 129． 3 gI/100 g,SV 186． 5 mgKOH/g.The results indicate that there are rich nutritional ingredients in the apple seed,which have wide prospect in the field of food.
Received support in the aftermath of Hurricane Florence: reciprocal relations among perceived support, community solidarity, and PTSD

ABSTRACT Background and Objectives: The social support deterioration model (SSDM) posits that individuals who do not receive adequate support following a disaster are vulnerable to losses in community solidarity and perceived support, as well as the development of persistent distress. However, limited longitudinal research has evaluated the relations among support and these outcomes among disaster-affected individuals. Design: The current study utilized random intercept cross-lagged panel modeling (RI-CLPM) to examine reciprocal relations among received support, community solidarity, perceived support, and posttraumatic stress disorder (PTSD) symptoms among rural Hurricane Florence survivors (n = 261) assessed 5–8 months post-hurricane (T1), and then at two more timepoints at three-month intervals (T2 and T3). Results: Results of the RI-CLPM supported that lower received support at T2 was associated with decreases in community solidarity at T3, and higher perceived support at T1 was associated with increases in received support at T2. In supplemental analyses, higher received support at T2 was associated with lower PTSD symptoms at T3. Conclusions: Consistent with the SSDM, individuals who receive less support post-disaster are vulnerable to losses in community solidarity and potentially persistent PTSD symptoms. Conversely, those with stronger support networks may be better able to access needed support in the longer-term.
Attempt to Quit Tobacco Smoking among Male Smokers in Vietnam and Predictive Factors: Findings from Global Adult Tobacco Survey (GATS)

Background: Vietnam is among countries with highest prevalence of tobacco smoking, attempt to quit is an important indicator to monitor the effectiveness of tobacco control efforts. This paper aims to describe smoking quit attempt and examine its association with some individual characteristics among male smokers. Methods: Data from the Global Adult Tobacco Survey in Vietnam in 2015 was analyzed for a sample of 1,903 male smokers taking from the national representative sample of 8,996 adults aged 15 years and above. Results: Proportion of quit attempt during 12 months prior to the interview among male smoker was 37.1%. Attempt to quit smoking was significantly associated with age (OR=2.84 and 95% CI: 1.43-5.66 for those aged 55 years and older vs. those aged 24 years and younger), with knowledge of harmful effects on health (OR=1.97 and 95% CI: 1.45-2.66 for those who could list 6 to 7 diseases vs. those who could list 3 or less diseases), number of channels with anti smoking message (OR=1.72 and 95% CI: 1.21-2.45 for those who had exposure from 3 channels or more vs. those who did not expose any channels), number of years smoking (OR=0.59 and OR=0.40 for those with less than 15 years smoking vs. those with 25 to 34 years smoking and more than 35 years smoking, respectively). Conclusion: Intervention to improve knowledge of tobacco harmful effects, and access to multiple and modern antismoking communication channels would be effective to raise quit attempt among smokers. Research to promote effectiveness of quit advice by health staff should be paid more attention.
Percutaneous closure of ventricular septal defect using LifeTechTM Konar-MF VSD Occluder: initial and short-term multi-institutional results

Abstract Background: Transcatheter ventricular septal defect closure remains a complex procedure with potential complications like complete heart block and aortic regurgitation. The ideal device design for such intervention is still evolving. Aim: To assess the safety, efficacy, and short-term outcome of ventricular septal defect closure using LifeTechTM multifunctional (KONAR-MFTM) VSD Occluder. Patients and methods: In a multicenre study, 44 patients with haemodynamically significant, restrictive ventricular septal defects underwent closure with the KONAR-MFTM device from April, 2019 to March, 2020. Clinical, echocardiographic, and angiographic data were collected and reviewed. Patients were followed up at 1, 3, 6, and 12 months. Results: The median age and weight were 8 (1.7–36) years and 20 (11–79) kg. Of 44 patients, 8 (18%) had a high muscular and 36 (82%) had a perimembranous defect, of which 6 had mild prolapse of the right coronary cusp. The median ventricular septal defect size was 8.8 (3.9–13.4) mm. A retrograde approach was adopted in 39 (88.6%) patients. Nine patients (20.5%) had a small residual leak and there was a slight increase in aortic regurgitation in one patient. One device, which embolised to pulmonary artery was retrieved, and the defect was closed with a larger device. At a median follow-up of 13 (5–18) months, the residual leak persisted in 1 (2.3%) patient. Mild aortic regurgitation in one patient remained unchanged. There were no major complications. Conclusion: Percutaneous closure of ventricular septal defect using KONAR-MFTM device is safe and effective in short and midterm follow-up including selected patients with perimembranous defect and mild prolapse of the right coronary cusp.
Photons from NIR LEDs can delay flowering in short-day soybean and Cannabis: Implications for phytochrome activity

Photons during the dark period delay flowering in short-day plants (SDP). Red photons applied at night convert phytochromes to the active far-red absorbing form (Pfr), leading to inhibition of flowering. Far-red photons (greater than 700 nm) re-induce flowering when applied after a pulse of red photons during the dark period. However, far-red photons at sufficiently high intensity and duration delay flowering in sensitive species. Mechanistically, this response occurs because phytochrome-red (Pr) absorbance is not zero beyond 700 nm. We applied nighttime photons from near infrared (NIR) LEDs (peak 850 nm) over a 12 h dark period. Flowering was delayed in Glycine max and Cannabis sativa (two photosensitive species) by 3 and 12 days, respectively, as the flux of photons from NIR LEDs was increased up to 83 and 116 μmol m-2 s-1. This suggests that long wavelength photons from NIR LEDs can activate phytochromes (convert Pr to Pfr) and thus alter plant development.
The Possible Contribution of being Born by Cesarean Section to Developing Childhood Overweight and Obesity in Later Life

Obesity is now a major global epidemic. In 2016, 39% of adults worldwide 18 years old were overweight, and 13% were obese, as reported by the World Health Organization (WHO). 1 This current scenario is compounded in highincome countries such as the United States, where 31% of the population has a body mass index (BMI)>30kg/m and 50%have awaist circumference 88cm, in the case ofwomen, or 102 cm in the case of men.2 Overweight and obesity are rapidly becoming amajor health issue, as these conditions are associated with severe chronic diseases such as diabetes, hypertension, and cardiovascular diseases in general.3 While it is largely agreed that obesity and overweight are the consequences of an unhealthy diet, mainly due to an increasing use of processed and preserved foods together with minimal physical activity, an association between cesarean delivery and obesity in later life has also been suggested. Cesarean section rates continue to increasewell beyondwhat could bemedically justified, and several studies conducted in different countries have found an association between being born by cesarean section and developing obesity in childhood or adulthood.4
Prevalence of Injuries Among Medicaid Enrolled Infants Prior to Child Abuse and Neglect

Prior research has identified common injuries among children who experience child maltreatment; however, most of this work has focused on inpatient settings and has excluded many cases of neglect. This study examines the prevalence of injuries that occur prior to a diagnosis of child maltreatment, as well as the proportion of children with well-child visits prior to the injury and child maltreatment diagnosis. Based on a secondary analysis of Medicaid data from four states, we found that among infants with 12 months of continuous enrollment (N = 4817), 30.6% of those diagnosed with maltreatment were previously diagnosed with an injury. Among infants diagnosed with child maltreatment, 88.4% had at least one well-child visit prior to the maltreatment diagnosis. Among children with a maltreatment diagnosis and a prior injury, 84% had at least one well-child visit preceding the injury. These results indicate that most children had at least one well-child visit prior to being diagnosed with child maltreatment or an injury, indicating opportunities for prevention.
Searching in the dark: Shining a light on some predictors of non-response to psychotherapy for borderline personality disorder

Background Borderline Personality Disorder (BPD) is a prevalent and serious mental health condition. People can experience recovery or remission after receiving psychotherapy for BPD; however, it is estimated that about 45% of people in well conducted treatment trials do not respond adequately to current psychological treatments. Aim To further advance psychotherapies for BPD by identifying the factors that contribute to the problem of non-response. Method 184 consecutive participants with BPD in community treatment were naturalistically followed up over 12 months and measures of personality and social functioning were examined. Logistic regressions were used to determine which baseline factors were associated with the likelihood of being a non-responder after 12 months of psychotherapy. After 12 months, 48.4% of participants were classed as non-responders due to a lack of reduction in BPD symptoms according to the Reliable Change Index (RCI) method. Results At baseline intake, patients who endorsed an adult preoccupied attachment relationship style and increased anger were more likely to be a non-responder regarding BPD symptoms at 12 months. In addition, those with preoccupied attachment patterns in their adult relationships were more likely to be non-responders regarding general psychological distress at follow up. Higher baseline levels of paranoia and endorsement of a dismissive adult relationship style was associated with being a non-responder in regard to global functioning. Conclusions Consistent with previous research, almost half of the sample did not achieve reliable change at 12-month follow up. A relationship style characterised by preoccupied insecurity and high anger seemed to be particularly challenging in being able to benefit from psychotherapy. This style may have affected both relationships outside, but also inside therapy, complicating treatment engagement and alliance with the therapist. Early identification and modification of treatment based on challenges from these relationship styles may be one way to improve psychotherapy outcomes for BPD.