Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive analysis of cucumber RAV family genes and functional characterization of CsRAV1 in salt and ABA tolerance in cucumber

The RAV (related to ABI3 and VP1) transcription factors are specific and exist in plants, which contain a B3 DNA binding domain and/or an APETALA2 (AP2) DNA binding domain. RAVs have been extensively studied in plants, and more and more evidences show that RAVs are involved in various aspects of plant growth and development, stress resistance and hormone signal transduction. However, the systematic analysis of RAV family in cucumber is rarely reported. In this study, eight CsRAV genes were identified in cucumber genome and we further comprehensively analyzed their protein physicochemical properties, conserved domains, gene structure and phylogenetic relationships. The synteny analysis and gene duplications of CsRAV genes were also analysed. Cis-element analysis revealed that the CsRAVs promoter contained several elements related to plant hormones and abiotic stress. Expression analysis showed that NaCl and ABA could significantly induce CsRAV genes expression. Subcellular localization revealed that all CsRAVs were localized in the nucleus. In addition, 35S:CsRAV1 transgenic Arabidopsis and cucumber seedlings enhanced NaCl and ABA tolerance, revealing CsRAV1 may be an important regulator of abiotic stress response. In conclusion, comprehensive analysis of CsRAVs would provide certain reference for understanding the evolution and function of the CsRAV genes.
Chinese undergraduates’ English reading self-efficacy, intrinsic cognitive load, boredom, and performance: A moderated mediation model

Introduction Research findings from various academic domains have demonstrated that students’ self-efficacy (SE) influences their academic performance while limited studies have explored how foreign language reading SE influences reading performance. The purpose of this quantitative study was to explore the relationship between reading SE, intrinsic cognitive load (CL), boredom, and reading performance. Methods The participants were 272 English-as-a-foreign-language (EFL) learners at a comprehensive university in China, who attended a compulsory English course for improving their English reading and writing proficiency. Data were analyzed through SPSS and structural equation modeling (SEM). Results The result of the study provided support for the hypothesized relationships. Students’ English reading SE is positively related to their reading performance and negatively related to intrinsic CL. Their intrinsic CL during reading comprehension is negatively related to reading performance. Reading boredom is negatively related to reading SE and reading performance but positively related to CL. Furthermore, students’ CL mediates the relationship between reading SE and performance while the negative achievement emotion of boredom moderates the relationship between reading SE and CL. Discussion The research highlights the importance of cognitive and emotional factors in influencing the relationship between foreign language reading self-efficacy and reading performance. Implications for EFL teachers and researchers are discussed.
The quasi-normal modes of the Schwarzschild black hole

The quasi-normal modes of a black hole represent solutions of the relevant perturbation equations which satisfy the boundary conditions appropriate for purely outgoing (gravitational) waves at infinity and purely ingoing waves at the horizon. For the Schwarzschild black hole the problem reduces to one of finding such solutions for a one-dimensional wave equation (Zerilli’s equation) for a potential which is positive everywhere and is of short-range. The notion of quasi-normal modes of such one-dimensional potential barriers is examined with two illustrative examples; and numerical solutions for Zerilli’s potential are obtained by integrating the associated Riccati equation.
Safety and efficacy of a modified busulfan/cyclophosphamide conditioning regimen incorporating cladribine for autologous hematopoietic stem cell transplantation in acute myeloid leukemia

This is a small phase I study examining the safety and efficacy of a cladribine (CLAD)-containing conditioning regimen prior to autologous hematopoietic stem cell transplantion (auto-HSCT) for patients with acute myeloid leukemia (AML). All patients, aged 15–54 years (median 32 years), had favorable/intermediate risk AML (n = 20) or acute promyelocytic leukemia (APL; n = 2) and no evidence of minimal residual disease (MRD) prior to transplantation. Fourteen of the 22 patients received the conditioning regimen as follows: busulfan (Bu) + cyclophosphamide (Cy) + CLAD + cytarabine (Ara-c) or idarubicin. The conditioning regimen of 8 patients was without Cy nor idarubicin to reducing adverse cardiac reaction: the regimen of Bu + CLAD+ Ara-c for 6 patients; and the regimen of Bu + melphalan + CLAD + Ara-c for the other 2 patients. All 22 AML patients received peripheral blood stem cell transplantation. The number of infused mononuclear cells and CD34+ cells was 10.00 (2.88–20.97) × 108/kg and 1.89 (1.52–10.44) × 106/kg, respectively. Hematopoietic reconstitution was achieved in all patients, with a median time of 13 (10–34) days for neutrophils and 28 (14–113) days for platelets. Two patients suffered from pulmonary infection, 4 patients suffered from septicemia during the neutropenic stage, and the others suffered from infection or gastrointestinal reaction without exceeding grade 3 after conditioning, which were all alleviated by anti-infection and other supportive treatment. None of the patients died of transplantation-related complications. At a median follow-up of 29.5 (ranging from 4.0 to 60.0) months, three patients relapsed after auto-HSCT at a median time of 6 (ranging from 0.5 to 10.0) months. One patient died due to relapse at 18 months after auto-HSCT. The remaining 21 patients were all alive, including 19 patients with negative MRD. The other 2 patients achieved negative MRD after allogeneic HSCT or chemotherapy. The estimated 2-year survival, relapse, and Leukemia-free survival rates were 94.1 ± 5.7%, 14.7 ± 7.9% and 85.3 ± 7.9%, respectively. A CLAD-combination conditioning regimen is efficient and safe for auto-HSCT, indicating an effective approach for AML treatment.
Monitoring treatment in pediatric patients with 21-hydroxylase deficiency

21-hydroxylase deficiency (21-OHD) is the most common form of congenital adrenal hyperplasia. In most developed countries, newborn screening enables diagnosis of 21-OHD in asymptomatic patients during the neonatal period. In addition, recent advances in genetic testing have facilitated diagnosing 21-OHD, particularly in patients with equivocal clinical information. On the other hand, many challenges related to treatment remain. The goals of glucocorticoid therapy for childhood 21-OHD are to maintain growth and maturation as in healthy children by compensating for cortisol deficiency and suppressing excess adrenal androgen production. It is not easy to calibrate the glucocorticoid dosage accurately for patients with 21-OHD. Auxological data, such as height, body weight, and bone age, are considered the gold standard for monitoring of 21-OHD, particularly in prepuberty. However, these data require months to a year to evaluate. Theoretically, biochemical monitoring using steroid metabolites allows a much shorter monitoring period (hours to days). However, there are many unsolved problems in the clinical setting. For example, many steroid metabolites are affected by the circadian rhythm and timing of medication. There is still a paucity of evidence for the utility of biochemical monitoring. In the present review, we have attempted to clarify the knowns and unknowns about treatment parameters in 21-OHD during childhood.
Exploring reconfiguration of trends in CPUE to model sustainable TAC options for the pivotal YSLME anchovy fishery

Sustainable utilization of exploited fish stocks generally relies on characterizing key aspects of their population dynamics using mathematical models to evaluate their stock status. In this study, the Anchovy population (Engraulis japonicus) in the Yellow Sea large marine ecosystem (YSLME) was evaluated by using the ‘Just Another Bayesian Biomass Assessment’ (JABBA) model. Catch and the anchovy scientific survey biomass index data from 1989 to 2021 in its nominal or raw form, plus three adjusted CPUE trends using data acquired from the China Fishery Statistical Yearbook were each used to fit JABBA to explore the performance of reconfigured CPUE for setting a total allowable catch (TAC) quota to sustain the YSLME commercial anchovy fishery. Results showed contrasting trends in estimated biomass from the fishery independent surveys, and nominal and reconfigured commercial fishery CPUE, with the latter producing the most plausible results. The JABBA output based on the scientific survey biomass index indicated a 56.7% probability that the anchovy stock is currently healthy with 1.04 B2021 /BMSY and 0.51 F2021 /FMSY ratios, whereas JABBA estimates based on the nominal commercial CPUE-based were overly optimistic (100% probability stock was healthy). JABBA outputs based on the first two reconfigured CPUEs (Facpuey and FECcpuey ) countered this overoptimism, with the survey biomass index-based assessment results lying between the extremes. This improvement in the modelled assessment was achieved because the reconfigured CPUE time series accommodated technological progress in fishing vessels and gear performance. Therefore, in instances where survey biomass index data are unavailable, we recommend using the two improved fishery CPUEs and combining the results of the two assessments to guide fishery management. Management reference points, however, should preferably be based on the more conservative of the two reconfigured CPUEs as a precautionary approach for setting a total allowable catch (TAC) whilst concomitantly considering the role of anchovy as prey for other economically important fish in the system.We encourage researchers to extensively review and improve the quality and availability of fisheries statistical data worldwide in the shared endeavour towards obtaining more realistic stock assessments.
Promoting creative autonomy support in school music education: An intervention study targeting interaction

Introduction The notion of autonomy in Self-Determination Theory is at the core of intrinsically motivated learning, and fulfilment of the need for autonomy is essential for thriving at school. Therefore teacher-provided autonomy support has grown into a key concern in educational research. In the present study into primary school music education, the notion of creative autonomy support is introduced. Research into autonomy support is typically focused on verbal interaction. However, from an enactive perspective, teachers’ gesturing, bodily movement, facial expression, and musical action form an integral part of the socially situated interaction in music lessons, inherently involving autonomy support. In the present study, a distinction is made between creative verbal autonomy support and creative musical and non-verbal autonomy support. Methods Applying a process-based time-serial methodology, rooted in a Complex Dynamic Systems and Enactive perspective, the effects of an intervention with Video Feedback Coaching for teachers were investigated. Video data of 105 music lessons of 18 teachers (intervention and control condition) from six primary schools was gathered, to examine teachers’ creative autonomy support at both the individual and group level. Results The findings show that teachers in the intervention condition, compared to the control group, achieved a meaningful increase in their ability to offer creative autonomy support verbally. Teachers also showed development for the non-verbal and musical aspects of offering creative autonomy support. However, particularly for offering higher-level creative autonomy support in the non-verbal and musical mode, significant results were found for less than half of the intervention teachers. Discussion These results underline the importance of embracing and studying the bodily dimension as an integral part of teacher autonomy support, aimed at emergence of students’ musical creativity, in primary school music education and in teacher training. We explain how these results might be relevant for autonomy enhancing musical activities in vulnerable groups.
S0033291722003518jrv 320..331

Although psychological treatments have been found to be effective for depression in adults, many individuals with depression do not actively seek help. It is currently unclear whether psychological treatments are effective among those not actively seeking help. Besides, little is known about the proportion of patients who completed a screening questionnaire who end up in a clinical trial. Therefore, we conducted a meta-analysis of 52 randomized trials comparing psychotherapies for adults with a diagnosis or elevated symptoms of depression against control conditions (care-as-usual, waiting list, and other inactive treatment). Only studies recruiting participants who do not actively seek help (participants who have been recruited through screening instead of advertisements and clinical referrals) were included. To obtain an overall effect estimate of psychotherapy, we pooled all post-test differences with a random-effects model. We found that psychological treatments had a moderate to high effect on reducing depressive symptoms compared to control groups [g = 0.55; 95% confidence interval (CI) 0.41–0.69]. Heterogeneity was high (I = 75%; 95% CI 68–80). At 12 months’ follow-up, the effects were small but significant (6–8 months: g = 0.33; 95% CI 0.14–0.52; 9–12 months: g = 0.24; 95% CI 0.11–0.37). As a secondary outcome, we found that 13% of patients who completed a screening questionnaire met the inclusion criteria for depression and agreed to be randomized in the trial. Based on the current evidence, psychological treatments for depression might be effective for depressed patients who are not actively seeking help.
Non-informative priors for the inverse Weibull distribution

In this paper, we develop the non-informative priors for the inverse Weibull model when the parameters of interest are the scale and the shape parameters. We develop the first-order and the second-order matching priors for both parameters. For the scale parameter, we reveal that the second-order matching prior is not a highest posterior density (HPD) matching prior, does not match the alternative coverage probabilities up to the second order and is not a cumulative distribution function (CDF) matching prior. Also for the shape parameter, we reveal that the second-order matching prior is an HPD matching prior and a CDF matching prior and also matches the alternative coverage probabilities up to the second order. For both parameters, we reveal that the one-at-a-time reference prior is the second-order matching prior, but Jeffreys’ prior is not the first-order and the second-order matching prior. A simulation study is performed to compare the target coverage probabilities and a real example is given.
Knots, groups, and spinning

In this note we observe how results of Gordon, Luecke, Feustel, and Whitten establish the precise extent to which knowledge of the knot group determines the knot, in both the oriented and the unoriented case. This enables us to say, in terms of the knot group, exactly when two spun knots are the same.
On the acceleration of charged particles at relativistic shock fronts

The diffusive acceleration of highly relativistic particles at a shock is reconsidered. Using the same physical assumptions as Blandford and Ostriker (1978), but dropping the restriction to nonrelativistic shock velocities, the authors find approximate solutions of the particle kinetic equation by generalizing the diffusion approximation to higher order terms in the anisotropy of the particle distribution. The general solution of the transport equation on either side of the shock is constructed, which involves the solution of an eigenvalue problem. By matching the two solutions at the shock, the spectral index of the resulting power law is found by taking into account a sufficiently large number of eigenfunctions. Low-order truncation corresponds to the standard diffusion approximation and to a somewhat more general method described by Peacock (1981). In addition to the energy spectrum, the method yields the angular distribution of the particles and its spatial dependence. 41 references.
Myriametric radiation and the efficiency of linear mode conversion

Linear mode coupling is often invoked to explain the conversion of electrostatic upper hybrid waves into terrestrial myriametric radiation. The efficiency of this conversion process can be studied by recently developed methods, which are based on the continuity equation for the wave distribution function. These estimates show that the efficiency of linear mode conversion is at least three orders of magnitude too low to account for the myriametric radiation observed in the magnetosphere.
Noncontact atomic force microscopy imaging of ultrathin Al2O3 on NiAl(110)

Noncontact atomic force microscopy (NC-AFM) has been used to image ultrathin film ${\mathrm{Al}}_{2}{\mathrm{O}}_{3}$ on NiAl(110). Atomic scale rows were observed with a 9 \AA{} periodicity. This provides support for a previous scanning tunneling microscopy study that concluded that the rows arise from the oxide rather than the underlying substrate. NC-AFM data image domain boundaries in the oxide film as either trenches or ridges, depending on the state of the tip. This suggests that NC-AFM does not simply trace the topography of the surface.
Martensitic and magnetic transformation in Mn50Ni50-xSnx ferromagnetic shape memory alloys

A martensitic transformation (MT) from a body-centered-cubic austenitic phase to a tetragonal martensitic phase has been found in Mn50Ni50−xSnx (0 ≤ x ≤ 11) alloys. The martensitic transformation temperature can be decreased by about 71.6 K by increasing the Sn concentration by 1 at. %. For 9 ≤ x ≤ 11, Mn50Ni50−xSnx ferromagnetic shape memory alloys are obtained. Due to the large magnetization difference (ΔM = 60 emu/g) and small thermal hysteresis (ΔT = 6 K) in the Mn50Ni40Sn10 alloy, a two-way magnetic-field-induced martensitic transformation is observed with dT/dH = 2 K/T.
Psychosocial well-being and mental adjustment of patients with stage III melanoma in the re-entry phase: a scoping review

Supplemental Digital Content is Available in the Text. Abstract Background: The number of patients with stage III melanoma is rising because of increasing incidence and improved survival thanks to newly available adjuvant treatments. Patients may face specific challenges in the re-entry phase, the first 18 months after treatment, because of a high risk of recurrence and the intensity and long-term side effects of adjuvant treatment. The aims of this scoping review included summarizing the current state of evidence concerning patient psychosocial well-being and mental adjustment to the re-entry phase, as well as identifying knowledge gaps. Methods: A systematic literature search was conducted in PubMed and CINAHL using the PRISMA-ScR checklist. Results: Two qualitative and seven quantitative studies were included. Some studies found no evidence of diminished social and emotional functioning compared with the general population, while others reported emotional distress and impairment in psychological health. Regarding existential health, frequently expressed concerns encompassed fear of recurrence, hopelessness, and uncertainty about the future. Patients typically used behavioral coping, cognitive coping, and meaning-making to manage challenges in the re-entry phase. Only one study considered the effects of adjuvant therapy use on the re-entry phase. Conclusions: Limited evidence is available on the psychosocial status of patients with stage III melanoma in the re-entry phase, a phase in which patients face existential concerns. It may be beneficial to provide patients with support regarding existential concerns and meaning-making, for example by developing a practical tool to help set meaningful goals for the re-entry phase. A better understanding of the psychosocial well-being of these patients, the impact of adjuvant therapy, and the relationship between emotional distress, existential concerns, and meaning-making will require further research.
Assessment of adherence to preoperative fasting guidelines and associated patient discomfort in adult elective surgical patients in public hospitals of Addis Ababa, Ethiopia: a multicenter cross-sectional study

Background: Preoperative fasting is compulsory before anesthesia to lower the risk of pulmonary aspiration. However, it is usually prolonged beyond the recommended time affecting the patient’s comfort and has several deleterious effects. Objective: To assess the adherence to preoperative fasting guidelines and associated patient discomfort in adult elective surgical patients in public hospitals of Addis Ababa, Ethiopia. Materials and methods: A multicenter cross-sectional study was conducted on 422 adult patients who underwent elective surgery at Addis Ababa public hospitals from February 20, to May 10, 2021. The collected data were entered into SPSS, version 24 for analysis. Spearman correlation and independent t test were used to assess the relationship between preoperative fasting time and explanatory variables, as appropriate. P value <0.05 was considered as statistically significant. Results: Majority (97.4%) of patients were instructed to fast from midnight regardless of the food type and schedule. Majority (98.1%) of the participants did not adhere to the preoperative fasting guidelines. The mean preoperative fasting time was 14.26±2.35 hours (range: 8–22 h) for solid foods and 13.89±2.37 hours (range: 8–21 h) for clear fluids. More than half (64%) of the participants felt preoperative discomfort, and factors contributing were thirst, hunger, mouth dryness, lengthy waiting of prior surgery, and tiredness. There was a moderate positive correlation between preoperative fasting time and severity of patient discomfort (P<0.001). There was also a strong positive correlation between total fasting time and the sequence of patient’s schedule (P<0.001). Conclusions: Preoperative fasting for solids and clear liquids was longer than the recommended international fasting guidelines. Preoperative fasting duration had an association with preoperative discomforting factors. Incorrect orders of instructions and changing sequences of schedule challenged the preoperative fasting adherence. Thus, preoperative fasting instructions should be clear, individualized; and health professionals need to communicate when surgery is delayed or changed.