Miracle-dz/UniFAR-FTUs huggingface dataset:
Test anxiety and emotion regulation among undergraduate medical students in 1 China: the mediating role of psychological resilience 2

47 Background: Medical students experience a considerable amount of anxiety due to exams. 48 Emotion regulation and psychological resilience are established protective factors of individual 49 mental health, however, the investigations for the effects of anxiety were limited. The goal of the 50 present study was to examine the relationship of psychological resilience and emotion regulation 51 with test anxiety and the associated factors of them among medical students. 52 Methods ： In this cross-sectional survey, a simple random sampling methods was used to select the 53 participants. Information from a sample of 1266 medical students was collected by self-reporting 54 questionnaires. Logistic regression was applied to test the associations between test anxiety and 55 emotion regulation, resilience. Bootstrap were conducted to explore the mediating role of 56 resilience. 57 Results: Our important results were that the prevalence of problematic test anxiety among 58 medical students to be 71.4%, 33.7% was high test anxiety. Gender and academic performance 59 correlated significantly with test anxiety, emotion regulation, and psychological resilience. There 60 were correlations between test anxiety and various dimensions of emotion regulation and 61 psychological resilience ( P<0.01 ). Emotion regulation and psychological resilience predicted 62 emerging test anxiety. The mediating role of psychological resilience was identified for the effects of 63 emotion regulation on test anxiety. awareness combination of curing and self-healing can solve the root cause of the problem and truly apply 69 psychological research to improving the mental health of the general public. 70 Our study results demonstrate that test anxiety, resilience and emotion regulation are closely associated both performance and genders. As the research show, higher levels of test while represent a higher level of well regulation. to gender
CESifo Working Paper Series STRATEGIC DELEGATION IN EXPERIMENTAL MARKETS

In this experiment, we analyze strategic delegation in a Cournot duopoly. Owners can choose among two different contracts which determine their managers' salaries. One contract simply gives managers incentives to maximize firm profits, while the second contract gives an additional sales bonus. Although theory predicts the second contract to be chosen, it is only rarely chosen in the experimental markets. This behavior is rational given that managers do not play according to the subgame perfect equilibrium prediction when asymmetric contracts are given.
Anti-Inflammatory Actions of St. John’s Wort: Inhibition of Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1 (cid:1) (STAT-1 (cid:1) ) Activation

St. John’s wort (SJW) has been described to show anti-inflam- matory properties due to its inhibitory effects on the expression of pro-inflammatory genes like cyclooxygenase-2, interleu- kin-6, and inducible nitric-oxide synthase (iNOS). Since iNOS plays a critical role in chronic inflammatory diseases, we have focused our attention on the regulation of iNOS expression by SJW in two different human epithelial cell lines, alveolar A549/8 and colon DLD-1 cells. SJW extract concentration dependently inhibited human iNOS expression evaluated by measuring the amounts of iNOS mRNA, iNOS protein, and NO production in both cell lines. This inhibitory effect resulted from transcrip-tional inhibition as shown in reporter gene experiments. With electrophoretic mobility shift experiments, we found a SJW-mediated down-regulation of the DNA binding activity of the transcription factor signal transducer and activator of transcrip-tion-1 (cid:1) (STAT-1 (cid:1) ), but not of nuclear factor- (cid:2) B. This down-regulation of the STAT-1 (cid:1) DNA binding was shown to result from reduced tyrosine phosphorylation of the STAT-1 (cid:1) protein. The diminished STAT-1 (cid:1) tyrosine phosphorylation resulted from SJW-mediated reduction of Janus kinase 2 activity. These data suggest that extracts from SJW may be a promising anti-inflammatory principle in chronic inflammatory diseases.
Cluster headache: review of current understandings VIEW AND REVIEW VIEW AND REVIEW VIEW AND REVIEW VIEW AND REVIEW VIEW AND REVIEW

Cluster headache (CH) is the trigeminal autonomic cephalalgia whose pain is considered to be one of the most severe known to man. Although diagnosed less frequently than migraine and tension-type headaches, CH is nonetheless an important clinical entity, particularly given our evolving understanding of its actual epidemiology, pathophysiology, current diagnostic criteria and treatment approaches. We carried out a systematic review through the United States National Library of Medicine (PUBMED) by using the search term "cluster headache" and the results were narrowed to manuscripts published in the last ten years with subsequent reference searches and verification of source data. This article presents a review of the current understanding of the most important aspects of CH, with emphasis on mechanisms and treatment approaches. Cluster headache: review of current understandings. Headache Medicine. 2012;3(1):5-12
On Sexual Dimorphism in Immune Function how this access benefits you. Your story matters

Sexual dimorphism in immune function is a common pattern in vertebrates and also in a number of invertebrates. Most often, females are more ‘immunocompetent’ than males. The underlying causes are explained by either the role of immunosuppressive substances, such as testosterone, or by fundamental differences in male and female life histories. Here, we investigate some of the main predictions of the immunocompetence handicap hypothesis (ICHH) in a comparative framework using mammals. We focus speciﬁcally on the prediction that measures of sexual competition across species explain the observed patterns of variation in sex-speciﬁc immunocompetence within species. Our results are not consistent with the ICHH, but we do ﬁnd that female mammals tend to have higher white blood cell counts (WBC), with some further associations between cell counts and longevity in females. We also document positive covariance between sexual dimorphism in immunity, as measured by a subset of WBC, and dimorphism in the duration of effective breeding. This is consistent with the application of ‘Bateman’s principle’ to immunity, with females maximizing ﬁtness by lengthening lifespan through greater investment in immune defences. Moreover, we present a meta-analysis of insect immunity, as the lack of testosterone in insects provides a means to investigate Bateman’s principle for immunity independently of the ICHH. Here, we also ﬁnd a systematic female bias in the expression of one of the two components of insect immune function that we investigated (phenoloxidase). From these analyses, we conclude that the mechanistic explanations of the ICHH lack empirical support. Instead, ﬁtness-related differences between the sexes are potentially sufﬁcient to explain many natural patterns in immunocompetence.
ON BLOW-UP CRITERION FOR THE NONLINEAR SCHR¨ODINGER EQUATION

The blowup is studied for the nonlinear Schr¨odinger equation iu t + ∆ u + | u | p − 1 u = 0 with p is odd and p ≥ 1 + 4 N − 2 (the energy-critical or energy-supercritical case). It is shown that the solution with negative energy E ( u 0 ) < 0 blows up in ﬁnite or inﬁnite time. A new proof is also presented for the previous result in [9], in which a similar result in a case of energy-subcritical was shown.
C5-Substituted 2-Selenouridines Ensure E ﬃ cient Base Pairing with Guanosine; Consequences for Reading the NNG-3 (cid:48) Synonymous mRNA Codons

: 5-Substituted 2-selenouridines (R5Se2U) are post-transcriptional modiﬁcations present in the ﬁrst anticodon position of transfer RNA. Their functional role in the regulation of gene expression is elusive. Here, we present e ﬃ cient syntheses of 5-methylaminomethyl-2-selenouridine ( 1 , mnm5Se2U), 5-carboxymethylaminomethyl-2-selenouridine ( 2 , cmnm5Se2U), and Se2U ( 3 ) alongside the crystal structure of the latter nucleoside. By using pH-dependent potentiometric titration, p K a values for the N3H groups of 1 – 3 were assessed to be signiﬁcantly lower compared to their 2-thio- and 2-oxo-congeners. At physiological conditions (pH 7.4), Se2-uridines 1 and 2 preferentially adopted the zwitterionic form ( ZI , ca. 90%), with the positive charge located at the amino alkyl side chain and the negative charge at the Se2-N3-O4 edge. As shown by density functional theory (DFT) calculations, this ZI form e ﬃ ciently bound to guanine, forming the so-called “new wobble base pair”, which was accepted by the ribosome architecture. These data suggest that the tRNA anticodons with wobble R5Se2Us may preferentially read the 5 (cid:48) -NNG-3 (cid:48) synonymous codons, unlike their 2-thio- and 2-oxo-precursors, which preferentially read the 5 (cid:48) -NNA-3 (cid:48) codons. Thus, the interplay between the levels of U-, S2U- and Se2U-tRNA may have a dominant role in the epitranscriptomic regulation of gene expression via reading of the synonymous 3 (cid:48) -A- and 3 (cid:48) -G-ending codons.
BIROn - Birkbeck Institutional Research Online

The neural factors that account for the visual processing-speed reduction in aging are incompletely understood. Based on previous reports of age-related decreases in the intrinsic functional connectivity (iFC) within the cingulo-opercular network and its relevance for processing speed, we hypothesized that these decreases are associated with age-related reductions in visual processing speed. We used a whole-report task and modeling based on Bundesen’s ‘theory of visual attention’ to parameterize visual processing speed in 91 healthy participants from 20 to 77 years old. iFC was estimated using independent-component analysis of resting-state fMRI data. From the clusters within the cingulo-opercular network exhibiting age-related decreased iFC, we found a cluster in the left insula to be particularly associated with visual processing speed and to mediate the age effect on visual speed. This mediation was not observed for age-related decreased iFC in other networks or for other attentional parameters. Our results point to the iFC in the cingulo-opercular network, represented by the left insula, as being a relevant marker for visual processing-speed changes in aging.
PREVALENCE OF INTERPROXIMAL CARIES IN PRIMARY MOLARS OF FIVE-YEAR-OLD CHILDREN AND ITS CONSEQUENCES ON OCCLUSION OF PERMANENT DENTITION

: Aim : The aim of this study was to investigate the difference in caries prevalence of number of interproximal surfaces between first and second primary molars based on quadrant dmfs in 5-year-old children. To gain knowledge about these aetiological factors of premature primary molars tooth loss and loss of space in the posterior segment is essential to take clinical decisions for the affected population and to establish a protocol for diagnosing and treating. Study design : Cross-sectional observational study. Place and duration of study: This study was carried out in Department of pedodontics Nishter Institute of dentistry Multan from feb 2019 to auguest 2019. Methods and statistics : For this study 435 children, all living in Multan city of punjab pakistan presented to our hospital were asked to participate. Clinical examinations were performed and only carious lesions on the mesial and distal surfaces with involvement of the dentine were reported. No radiographs were taken. Systematic differences in dmfs between first and second molars in the same quadrant of each primary dentition were tested with the Wilcoxon signed rank test. Results : Second primary molars, even after correction for caries had a statistically significant higher total dmfs than the first primary molars. On proximal surfaces, the first primary molars had significant more caries than the second primary molars. The d-component constituted the major part of the caries index. Conclusions : Second primary molars, corrected for decay in the pits and buccal/palatal fissures of this molar, are more affected by caries than first primary molars. Correlation was observed between the variable loss of space and the number of interproximal surfaces on the primary Molar involved.
EVALUASI PROGRAM KURIKULUM BERDASARKAN STANDAR ISI, STANDAR PROSES, DAN STANDAR KOMPETENSI LULUSAN DI SDN PISANGAN TIMUR 10 PAGI

enelitian ini bertujuan untuk mengetahui pelaksanaan Kurikulum Tingkat Satuan Pendidikan (KTSP) di Pisangan Timur 10 Pagi. Metode penelitian dalam penelitian ini adalah deskriptif evaluatif dengan model CIPP (Context, Input, Process, Product). Peneliti menggunakan model CIPP karena pembagian keempat komponen yang ada memudahkan peneliti dalam mengevaluasi standar isi, standar proses, dan standar kompetensi lulusan di tempat penelitian. Penelitian yang dilaksanakan memberikan beberapa gambaran serta beberapa penilaian dari peneliti sendiri berdasarkan instrumen yang peneliti gunakan di antaranya seperti kesesuaian silabus, rencana pelaksanaan pembelajaran (RPP), media pembelajaran, kualifikasi dan kompetensi guru, dan komponen akreditasi yang sesuai dengan Badan Akreditasi Nasional. Hasil penelitian menunjukkan untuk komponen Context terdapat kesesuaian untuk tujuan, latar belakang, dan prinsip pengembangan kurikulum sesuai dengan Peraturan Pemerintah. Pada komponen Input, yaitu perangkat pembelajaran dan kualifikasi dan kompetensi guru telah sesuai dengan ketentuan peraturan. Demikian juga pada komponen Process, yaitu prosedur untuk perencanaan dan pelaksanaan kurikulum sudah sesuai dengan peraturan. Adapun pada komponen Product yang mengacu pada pedoman akreditasi memenuhi syarat dengan hasil A, menunjukkan bahwa pelaksanaan kurikulum di sekolah ini memenuhi kriteria sangat baik dan dianjurkan untuk digunakan kembali di tahun ajaran berikutnya. Kata kunci: , ,
The Grunewald–O'Halloran Conjecture for Nilpotent Lie Algebras of Rank ≥1

Grunewald and O'Halloran conjectured in 1993 that every complex nilpotent Lie algebra is the degeneration of another, nonisomorphic, Lie algebra. We prove the conjecture for the class of nilpotent Lie algebras admitting a semisimple derivation, and also for 7-dimensional nilpotent Lie algebras. The conjecture remains open for characteristically nilpotent Lie algebras of dimension grater than or equal to 8.
A realistic review to explore how low­income pregnant women use food vouchers from the UK's Health Start programme

Objectives To explore how low-income pregnant women use Healthy Start food vouchers, the potential impacts of the programme, and which women might experience these impacts and why. Design A realist review. Eligibility criteria for selecting studies Primary or empirical studies (of any design) were included if they contributed relevant evidence or insights about how low-income women use food vouchers from the Healthy Start (UK) or the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) programmes. The assessment of ‘relevance’ was deliberately broad to ensure that reviewers remained open to new ideas from a variety of sources of evidence. Analysis A combination of evidence synthesis and realist analysis techniques was used to modify, refine and substantiate programme theories, which were constructed as explanatory ‘context–mechanism–outcome’– configurations. Results 38 primary studies were included in this review: four studies on Healthy Start and 34 studies on WIC. Two main outcome strands were identified: dietary improvements (intended) and financial assistance (unintended). Three evidence-informed programme theories were proposed to explain how aspects of context (and mechanisms) may generate these outcomes: the ‘relative value’ of healthy eating (prioritisation of resources); retailer discretion (pressure to ‘bend the rules’); the influence of other family members (disempowerment). Conclusions This realist review suggests that some low-income pregnant women may use Healthy Start vouchers to increase their consumption of fruits and vegetables and plain cow’s milk, whereas others may use them to reduce food expenditure and save money for other things.
IDENTIFICATION OF NAVEL ORANGE LESIONS BY NONLINEAR DEEP LEARNING ALGORITHM

A parametric exponential nonlinear function is proposed to replace the activation layer of the deep learning classification network, which makes the deep neural network have better generalization ability. And the improved classification network is applied to identify the navel orange lesion. This new identification method has the great advantage of being convenient to use and more accurate for the identification of traditional plant diseases. The model was trained by using the sampled leaf images of diseased, deficient, normal and non-species, and finally reached the 97.26% ~ 98.44% test accuracy and 100% recognition rate. The code and model are available at the website https://github.com/xncaffe/caffe_penlu.
Sinomenine Inhibits the Growth of Ovarian Cancer Cells Through the Suppression of Mitosis by Down-Regulating the Expression and the Activity of CDK1

Introduction: Ovarian cancer is one of the most common gynecological cancers worldwide. While, therapies against ovarian cancer have not been completely effective, sinomenine has been proved to have anti-tumor activity in various cancer cells. However, study of its anti-ovarian cancer effect is still rare, and the underlying mechanism has not been elucidated. Therefore, we aim to explore the mechanism of sinomenine anti-ovarian cancer. Materials and Methods: The effect of anti-ovarian cancer HeyA8 cells was analyzed by CCK8 and colony formation assay. The mechanism of sinomenine anti-ovarian cancer was explored via high throughput RNA-seq, and then the target mRNA and protein expression were verified by real-time PCR and Western blot, respectively. Results: We found that the proliferation and clone formation ability of ovarian cancer HeyA8 cells were markedly reduced by 1.56 mM sinomenine. The transcriptome analysis showed that 2679 genes were differentially expressed after sinomenine treatment in HeyA8 cells, including 1323 down-regulated genes and 1356 up-regulated genes. Gene ontology and KEGG pathway enrichment indicated that differential expression genes (DEGs) between the groups of sinomenine and DMSO-treated HeyA8 cells were mainly involved in the process of the cell cycle, such as kinetochore organization, chromosome segregation, and DNA replication. Strikingly, the top 18 ranked degree genes in the protein–protein interaction (PPI) network were mainly involved in the process of mitosis, such as sister chromatid segregation, condensed chromosome, and microtubule cytoskeleton organization. Moreover, real-time PCR results showed consistent expression trends of DEGs with transcriptome analysis. The results of Western blot showed the expression level of CDK1, which was the highest degree gene in PPI and the main regulator controlling the process of mitosis, and the levels of phosphorylated P-CDK (Thr161) and P-Histone H3 (Ser10) were decreased after being treated with sinomenine. Conclusion: Our results demonstrated that sinomenine inhibited the proliferation of HeyA8 cells through suppressing mitosis by down-regulating the expression and the activity of CDK1. The study may provide a preliminary research basis for the application of sinomenine in anti-ovarian cancer.
Transionospheric pulse pairs originating in maritime, continental, and coastal thunderstorms: Pulse energy ratios

We examine the ratio of energy in the second pulse to energy in the first pulse for 2467 transionospheric pulse pairs (TIPPs). The TIPPs examined here have been attributed to thunderstorms occurring over maritime, continental, and coastal regions near the continental United States. The mean values of the energy ratios are found to be 0.39 ± 0.27 for continental TIPPs and 0.94 ± 0.62 for maritime TIPPs. The energy ratio values for the coastal TIPPs exhibit a bimodal distribution representative of both the continental and the maritime populations. Previous observational evidence has shown that the second pulse of a TIPP is the surface‐reflected signal from the same source as the first pulse. We compare the observed pulse energy ratios to the reflection coefficients of soil and seawater given by the Fresnel equations. The average values of the reflection coefficients for sources with vertical plane and horizontal plane polarization are consistent with the data.
The role of incentives towards adolescents’ commitment to use public transport in Malaysia

ABSTRACT This study examines the adoption of a travel behaviour modification programme to encourage sustainable mobility and public bus usage. Students from four schools in Penang Island were recruited and divided into two groups: Group 1 (without incentives) and Group 2 (with incentives). In the experiment, after having a motivation session about sustainable transport, the respondents were asked to design their travel patterns for seven days. The next session gathered data about their actual travel and asked for feedback regarding the programme. The results demonstrate that incentives encouraged respondents to follow their plans for travel behaviour and public bus usage. The results highlight that their commitment to follow their travel plans were influenced by ethnicity, distance from home to school, travel time, and household income. The study offers some discussion regarding the implications of the results for strengthening sustainable mobility and encouraging public bus use among adolescents.
Long-term but not short-term p38MAPK inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction

p38 Mitogen-activated protein kinase (p38MAPK) inhibition exerts beneficial effects on left ventricular (LV) remodeling and dysfunction. p38MAPK activity is transiently increased soon after myocardial infarction (MI), suggesting brief inhibition may afford the same benefit as long-term inhibition. We examined chronic 12 week p38MAPK inhibition compared to short term (7 day) then discontinued inhibition post-MI. Post-MI rats at day 7 received either vehicle, RWJ67657 (RWJ; (4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1 H imidazol-2-yl]-3-butyn-1-ol) for 12 weeks (long-term; LT-RWJ), RWJ for 1 week and discontinued for 11 weeks (1 wk-RWJ), or continuous ramipril for 12 weeks. In separate groups of animals, 24 hours post-MI, vehicle or RWJ was administered for 7 days. Cardiac function was assessed by echocardiography and hemodynamic measurements. Percentage fractional shortening improved following LT-RWJ and ramipril, but not 1wk-RWJ treatment. Similarly LV contractility, dP/dt max , was improved (12.5%, 14.4%), and LV end diastolic pressure (LVEDP) was reduced (49.4%, 54.6%) with both treatments. Functional outcomes were accompanied by regression of interstitial collagen I and α -smooth muscle actin expression in LV non-infarct, border and infarct regions with LT-RWJ and Ram treatment. Hypertrophy was reduced in non-infarct (18.3%, 12.2%) and border regions (16.3%, 12.0%) with both treatments respectively. Animals receiving RWJ 24 hours post-MI for 7 days showed similar improvements in fractional shortening, dP/dt max , LVEDP, including reduced fibrosis and hypertrophy. In