Miracle-dz/UniFAR-FTUs huggingface dataset:
Final Overall Survival Analysis From a Study Comparing First-Line Crizotinib With Chemotherapy: Results From PROFILE 1014

PurposeThe phase III PROFILE 1014 trial compared crizotinib with chemotherapy as first-line treatment in patients with anaplastic lymphoma kinase (ALK) –positive advanced nonsquamous non–small-cell lung cancer. Here, we report the final overall survival (OS) results.Patients and MethodsPatients were randomly assigned to receive oral crizotinib 250 mg twice daily (n = 172) or intravenous pemetrexed 500 mg/m2 plus cisplatin 75 mg/m2 or carboplatin (area under the concentration–time curve of 5 to 6 mg·mL/min) every 3 weeks for a maximum of six cycles (n = 171). Crossover to crizotinib was permitted after disease progression. OS was analyzed using a stratified log-rank test and a prespecified rank-preserving structural failure time model to account for crossover.ResultsMedian follow-up duration for OS was approximately 46 months for both arms. In the chemotherapy arm, 144 patients (84.2%) received crizotinib in subsequent lines. Hazard ratio for OS was 0.760 (95% CI, 0.548 to 1.053; two-sided P = .0978). Medi.
To Compare the Accuracy of Clinical and Sonographic Estimation of Fetal Weight among Different BMI Antenatal Groups.

Objective: To assess the accuracy of clinical and sonographical estimation of fetal weight in different BMI groups of term antenatal patients Methods: This was a prospective observational study in which 1000 term antenatal patients admitted for delivery were recruited. Their present BMI was calculated to know the effects of current BMI on both clinical and sonographical methods of fetal weight estimation and were divided into four groups – Underweight, Normal, Overweight, and Obese. In each group fetal weight was estimated by both methods and compared with actual birth-weight after delivery. Statistical Analysis: Bland and Altman plots were used to show the limits of agreement, and intra class correlation coefficients to show the performance for estimating fetal weight. Results: The accuracy of sonographically estimated fetal weight was better than clinically estimated fetal weight in all groups of BMI as well as for whole group. The ICC of ultrasonic measurements were 0.82(95%CI 0.65-0.89), 0.62(95%CI 0.26-0.80), 0.78(95%CI 0.52-0.83), 0.86(95%CI 0.54-0.94) and 0.80(95%CI 0.71-0.86) respectively for whole sample and underweight, normal, overweight and obese women and found to be statistically significant at 1% level of confidence. Conclusion: The sonographically estimated fetal weight was better than clinically estimated fetal weight and not affected by maternal BMI.
Growth Performance and Hematological Characteristics of West African Dwarf Goats Fed Oil Palm Leaf Meal Cassava Peel Based Diets

The growth performance and hematological characteristics of West African Dwarf (WAD) goats fed oil palm leaf meal – cassava peel based diets were determined. Nine growing bucks aged 6 – 8months with mean body weight ranging between 7 – 8kg were randomly assigned to three dietary treatments comprising three animals per treatment in a Completely Randomized Design (CRD). Treatment 1 served as a control diet with 0% oil palm leaf meal (OPLM) while treatments II and III contained 15% and 30% oil palm leaf meal respectively. Each animal received each diet for 60days. The animals were weighed weekly. Blood was collected through the jugular vein and put into well labeled bottle containing anticoagulant ethylene diamine tetracetic acid (EDTA). The blood samples were analyzed for red blood cell (RBC) count, packed cell volume (PCV), hemoglobin (Hb), white blood cell (WBC) count, neutrophils, lymphocytes, eosinophils and monocytes. Final body weight was significant (P 0.05). The body weight and the nutritional health status of the goats can be enhanced with the inclusion of oil palm leaf meal in a cassava peel based diet.
The inhibitory effects of cisplatin-radiation combination treatment on malignant osteosarcoma MG-63 cells and BRCA1-p53 pathways are more efficient than single treatments

The poor prognosis of patients with osteosarcoma remains a persistent problem, in particular for patients with unresectable tumors or metastasis. Therefore, combination of radiotherapy and chemotherapy has been considered for patients with metastasis or recurrence, patients unsuitable for surgery and patients refusing surgery. The present study aimed to investigate the effect of the combined treatment with cisplatin and radiation therapy on the biological characteristics of the osteosarcoma cell line MG-63 and the breast cancer 1 (BRCA1)-associated signaling pathways. Cell proliferation was determined using Cell Counting kit-8 assay, and cell apoptosis and cell cycle were assessed by flow cytometry. Cell migration was examined by Transwell assay. The mRNA and protein expression levels of candidate genes, including BRCA1 and p53, were determined by reverse transcription-quantitative PCR and western blotting, respectively. The results demonstrated that combined treatment with radiation and cisplatin significantly inhibited MG-63 cell proliferation compared with radiation or cisplatin treatment alone. Furthermore, radiation, cisplatin or the combined treatment with radiation and cisplatin increased the apoptosis rate of MG-63 cells, which resulted in G2 phase arrest, and significantly decreased the migratory capacity of MG-63 cells. In addition, the apoptosis rate of MG-63 cells following combined radiation and cisplatin treatment was higher compared with the cisplatin group, but lower compared with the radiation group. Furthermore, combined treatment with radiation and cisplatin decreased the mRNA and protein expression levels of BRCA1 and p53. Additionally, combined treatment with radiation and cisplatin had a more potent inhibitory effect on p53 expression than on BRCA1 expression. In addition, combination of radiation and cisplatin had a higher inhibitory effect on Bax protein level and a higher inductive effect on Bcl-2 protein level compared with treatments with radiation and cisplatin alone. The results demonstrated that combined treatment of radiation and cisplatin exhibited superior therapeutic effects on osteosarcoma MG-63 cells compared with radiation or cisplatin treatment alone, which may be mediated by the BRCA1-p53 signaling pathway.
An MRI-Based Quantification for Correlation of Imaging Biomarker and Clinical Performance in Chronic Phase of Carbon Monoxide Poisoning

Purpose: The purpose of this study was to determine the relation between quantitative magnetic resonance imaging biomarkers, and clinical performances in chronic phase of carbon monoxide intoxication. Materials and Methods: Eighteen magnetic resonance scans and cognitive evaluations were performed, on patients with carbon monoxide intoxication in chronic phase. Apparent diffusion coefficient (ADC) ratios of affected versus unaffected centrum semiovale, and corpus callosum were obtained. Signal intensity (SI) ratios between affected centrum semiovale, and normal pons in T2-FLAIR (fluidattenuated inversion recovery) images were obtained. The Mini-Mental State Exam, and clinical outcome scores were assessed. Correlation coefficients were calculated, between MRI and clinical markers. Patients were further classified into poor-outcome and good-outcome groups based on clinical performance, and imaging parameters were compared. T2-SI ratio of centrum semiovale was compared, with that of 18 sexmatched and age-matched controls. Results: T2-SI ratio of centrum semiovale was significantly higher in the pooroutcome group, than that in the good-outcome group and was strongly inversely correlated, with results from the Mini-Mental State Exam. ADC ratios of centrum semiovale were significantly lower in the poor outcome group than in the good outcome group, and were moderately correlated with the Mini-Mental State Exam score. Conclusion: A higher T2-SI and a lower ratio of ADC values in the centrum semiovale, may indicate presence of more severe white matter injury and clinical impairment. T2-SI ratio and ADC values in the centrum semiovale, are useful quantitative imaging biomarkers for correlation with clinical performance in individuals with carbon monoxide intoxication.
Rural Adolescents' Attitudes to Seeking Help for Mental Health Problems

Little research has been undertaken into the barriers facing rural adolescents seeking help and support for mental health problems. This study presented students from rural secondary schools in Victoria with hypothetical scenarios involving adolescents in rural areas with mental disorders and posed questions in order to create group discussion. The results revealed a range of perceived barriers to help-seeking that could be considered unique to rural settings. However, adolescents also expressed positive attitudes and identified a range of professional help sources available to them. The findings support recent moves towards providing school-based mental health services to young people in rural areas.
Can Psychological Interventions Reduce Mortality Rates in Patients with Coronary Heart Disease and Cancer? A Review of Randomized Trials

This paper reviews evidence on the impact of psychological interventions on survival in patients suffering from one of two leading causes of death in developed countries: coronary heart disease and cancer. “Psychological interventions” in this context refers to those procedures commonly thought of as psychotherapy. Studies employing randomized controlled trials (RCTs) are considered. While there are inconsistencies in the literature, there is promising evidence on the potential for psychotherapy to affect survival from these two diseases. Beneficial effects on survival have been documented in about half of the controlled trials that have been reported in the literature. Limitations of these findings are considered and promising directions for future research identified.
Facteurs échographiques prédictifs du maintien du rythme sinusal un an après cardioversion pour trouble du rythme auriculaire non valvulaire.

La recherche de parametres echocardiographiques predictifs du maintien du rythme sinusal apres succes de cardioversion a ete etudiee chez 94 patients ayant un trouble du rythme auriculaire d'origine non valvulaire de survenue recente. Soixante-quinze patients en arythmie complete par fibrillation auriculaire et 19 patients presentant un flutter auriculaire, hospitalises pour reduction du trouble du rythme, ont beneficie d'une echocardiographie transthoracique et transœesophagienne. Apres avoir elimine la presence d'un thrombus auriculaire gauche ou controle sa disparition (5 patients), une cardioversion electrique (n = 74) ou pharmacologique (n = 20) ete realisee avec succes. Le maintien du rythme sinusal (n = 44) ou la recidive de l'arythmie (n = 50) ont ete controles tous les 3 mois pendant un an. La valeur moyenne du pic de vitesse positif du flux doppler mesure dans l'auricule gauche est de 38 ± 20 cm/s pour l'ensemble des patients. Aucun parametre echographique predictif du maintien du rythme sinusal a un an n'a pu etre identifie, ni dans la population globale, ni dans les sous-groupes en fibrillation auriculaire ou en flutter. Dans le goupe en flutter, la valeur moyenne du pic de vitesse positif du flux de l'auricule gauche est significativement plus elevee que dans le groupe de fibrillation auriculaire: 49 ± 22 cm/s versus 35 ± 18 cm/s respectivement, p < 0,05. Le pic de vitesse positif du flux de l'auricule gauche est statistiquement correle aux parametres indirects de fonction auriculaire gauche et a la fonction ventriculaire gauche dans le groupe des fibrillations auriculaires et seulement aux parametres de fonction ventriculaire gauche dans le groupe plus restreint des flutters auriculaires.
Obesity related hypertension - gender specific analysis among adults in Tanjung Karang, Selangor, Malaysia

Obesity is a major health concern and the growing rate raises important issues specific to concurrent rise of the related diseases especially hypertension. This study aimed to determine the relationship between hypertension and obesity based on body mass index and waist circumference besides relevant sociodemographic factors according to gender specific analysis. The analysis is important to determine in depth insight of two genders. This cross-sectional study was conducted among community in Tanjung Karang, Selangor, Malaysia in 2009 and included a total of 439 male and 668 female respondents aged 18-59 years old. Data was collected by interview-guided questionnaire and anthropometric measurements. SPSS version 21.0 was used for analysis of the relationship between socio demographic factors, smoking, body mass index and waist circumference with hypertension. Finally logistic regression analysis was used to assess the predictors of hypertension according to gender. The prevalence of hypertension was 25.5% in males and 23.1% in females, giving a total of 24%. Significantly higher prevalence of hypertension was found in overweight and obese categories (42.2% and 60.5% in males; 39.5% and 48.9% in females). Those with abdominal obesity also had significantly greater risk in having hypertension (41.6% in males and 33.2% in females). The logistic regression analysis indicated that age, high BMI and abdominal obesity were significantly associated with hypertension in women, and on the other hand age and BMI only for men. Both obesity and abdominal obesity are significantly important predictors of hypertension in females but BMI obesity only in males. Effective weight management strategies targeting obese people and abdominally obese women should be implemented in order to prevent hypertension and related cardiovascular diseases.
The Ophelia (OPtimise HEalth LIteracy and Access) Process. Using health literacy alongside grounded and participatory approaches to develop interventions in partnership with marginalised populations

This paper seeks to explore the potential of a newly developed, grounded and participatory approach to development of health-literacy and health-care access interventions for equity – the Ophelia (OPtimising HEalth LIteracy and Access) process (Batterham et al., 2014). The methodology involves undertaking a needs assessment of the target population using intensive qualitative and quantitative methods, developing vignettes of key sub-groups within the population based on their health literacy profile of strengths and weaknesses, and then engaging with frontline practitioners and community membersin developing realistic solutions (Batterham et al., 2014).
Medical termination of pregnancy and concurrent contraceptive acceptance.

This paper explores among women the acceptability of permanent or temporary contraceptive methods following medical termination of pregnancy (MTP) in relation to socio-demographic characteristics awareness of contraceptive methods past contraceptive use and quality of counselling and services. Correlation effects are sought with the understanding that post-MTP contraception plays important roles in both demographics and maternal health for high parity women. The study was undertaken by the Family Planning Association of India between 1986 and 1988 and included 1042 women who accepted contraceptive methods following MTP. The study revealed a positive correlation between post-MTP family planning acceptance and education. Following an established trend women desired to have an average of 3 or more living children including both sons and daughters prior to accepting sterilization. Only 50% of the studied sample had employed a method before visiting the clinic and knowledge level regarding family planning methods is discussed. For the 3 major methods condom female sterilization and IUD over 60% were knowledgeable compared to 84% who knew at least 1 method. Fundamental to acceptance and continuation was proper counseling. A majority of the MTP acceptors had not received information on other methods method effectiveness method side effects and/or complications use instructions and steps to take in the event of trouble. The paper calls for increasing the quality of counseling to reinforce clients confidence in using chosen methods.
Atherosclerosis an Association with Chronic Kidney Disease in Rheumatoid Arthritis Patients

Submit Date 2019-09-07 Revise Date 2019-10-07 Accept Date 2019-10-11 ABSTRACT Background: Rheumatoid arthritis (RA), an autoimmune systemic inflammatory condition, associated with an increased risk of cardiovascular disease (CVD). Recently, renal impairment was suggested to increase the risk of CVD in RA population. Aim of this study: it was to evaluate the association between impaired renal function and atherosclerosis in patients of rheumatoid arthritis . Rational: In the light of the increased incidence of renal affection in RA patients and the reported association with the cardiovascular complications which cause excess mortality in patients of rheumatoid arthritis . We studied if there was association between impaired renal function and accelerating atherosclerosis in rheumatoid arthritis. Patients and Methods: A cross sectional study on 72 RA patients carried out at Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University. The disease activity was evaluated by the Disease Activity Score (DAS28). Clinical and laboratory assessment was performed with evaluation of carotid intima-media thickness (cIMT) and the presence of atherosclerotic plaques by Carotid ultrasonography, glomerular filtration rate (GFR) was estimated with Modification of diet in renal diseases ( MDRD ) formula to define chronic kidney disease (CKD). C-reactive protein (CRP) , rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and serum amyloid A ( SAA) were used as inflammation markers, Results: In this study we found that carotid intima-media thickness was abnormal in 33 (46%) of the patients. Age, waist circumference (WC) and disease duration found to be significantly higher in patients with abnormal cIMT. Besides CRP, RF, ESR, SAA and DAS28 were significantly higher with abnormal cIMT , while eGFR was significantly decreased in patients with abnormal cIMT. In the present study it was found that there was highly negative significant correlation between cIMT and eGFR. Conclusion: The presence of impaired renal function and long standing inflammation were associated with higher risk of atherosclerosis in RA population.
Alzheimer’s disease and the utilisation of procedural learning

This thesis investigated the utilisation of procedural learning to improve self-care tasks and activities of daily living (ADLs) in mild-to-moderate Alzheimer's disease (AD). Procedural learning is relatively preserved in AD, presumably due to relatively little degeneration of critical neural circuits. Current interventions for AD (medical and nonmedical) have limited effects on these skills, and attempts to enhance memory with explicit learning methods have been largely ineffective. Two studies assessed the effectiveness of procedural training for ADLs in AD. Study one involved both a group and single subject design (multiple baseline across tasks) with 12 pre-selected tasks. Eight AD participants were trained on six tasks (counterbalanced across subjects) for 10 days, six tasks remained untrained. The group showed significant improvement at post-test in performance time and number of errors for trained tasks, whereas untrained tasks showed no significant change. At post-test no significant difference was found between the AD and control groups on trained tasks. Seven of the 8 participants showed a significant decrease in overall performance time (binomial analyses) and errors (visual analyses) for trained tasks. Significant training effects were maintained at 12-week follow-up. There was variability in training effectiveness between individuals and tasks. Study two assessed the effectiveness of individually-tailored training programmes, in which tasks were selected for each individual according to task impairment and relevance. A single subject design, multiple baseline across tasks, was repeated across 6 participants. Change in task performance (time or errors) coincided with the onset of training. At post-test all participants showed some training benefits in either performance time or number of errors: 4 showed training effects on 77 to 100% of their tasks and 1 participant showed training effects in 60% of tasks. The final participant showed training effects in 75% of tasks, although a truncated follow-up period limited analyses. Training benefits endured throughout follow-up for 3 participants (2 to 4 months), and for at least 5 months for the 2 participants who had longer follow-up periods (some tasks endured up to 10 (KW) and 13 months (PB)). Procedural learning methods can assist individuals with mild-to-moderate AD maintain self-care skills and ADLs. Additionally, this method could be adapted to provide a model of effective communication for caregivers, for example, breaking tasks into components and presenting requests one at a time.
Minimal Stimulation IVF 2

Minimal stimulation IVF was utilized in the early IVF experiences. It is proposed now as a solution for the unwanted consequences and costs of current conventional IVF protocols. Minimal stimulation IVF is thought to be a means to achieve some of the fertility-enhancing effects of IVF while minimizing discomforts, risks (especially of ovarian hyperstimulation syndrome), and costs. An additional benefit is a marked reduction in the likelihood of unused embryos. In aggregate, these advantages should increase the access to and acceptability of IVF for many potential patients. While the per cycle pregnancy rate in minimal stimulation IVF is lower than that of conventional protocols, proponents of this method cite increased patient tolerance and access that allow multiple efforts, with a cumulative success rate that can approach that of a single cycle of conventional IVF (Curr Opin Obstet Gynecol 22:189–192, 2010). Minimal stimulation IVF is now being offered in many fertility clinics both to young patients with good prognosis and to poor responders and women of advanced age as an alternative to conventional protocols. The renewed interest in minimal stimulation IVF is largely a result of improved outcomes in the IVF laboratory that have led to higher likelihoods of viable embryos and better success rates with single embryo transfer.