Miracle-dz/UniFAR-FTUs huggingface dataset:
The experiences of care home staff during the COVID-19 pandemic: A systematic review

Abstract Objectives: To examine experiences of care home staff to better understand how to support them during the ongoing pandemic and in the future. Method: A systematic review examining experiences of care staff over the last year (March 2020-2021). Results: Fourteen papers related to experiences of staff and one was an intervention study. Quantitatively there was evidence of anxiety, PTSD and depression amongst the staff. Qualitatively, seven themes were identified: Poor working conditions; Lack of skills and knowledge; Psychological/Mental health concerns; Feeling undervalued and abandoned; Fears of contagion; Support and the positive impacts of COVID. The intervention study recommended employing needs-based approaches, including educational and wellbeing components. Conclusion: Recommendations are made in terms of how to work with staff, both practically and clinically. There are also suggestions about how to deal with similar situations if they were to reoccur. It is evident that lessons need to be learned because errors were made. Indeed, from a UK perspective, discharging thousands back to care homes, without testing, cost lives. This may have been done to protect the NHS, but it unwittingly ‘lockdown’ the virus within the care sector.
Influence of the ABO Blood Group System on Hepatocellular Carcinoma Recurrence After Liver Transplantation

Background. The ABO blood group system may influence tumorigenesis, but its prognostic value in liver transplantation (LT) for hepatocellular carcinoma (HCC) has never been assessed. Methods. All consecutive patients who underwent LT for HCC between 2013 and 2017 at 9 centers were analyzed. Predictors of tumor recurrence were identified using multivariable analysis, while comparison between group A and non-A recipients was performed after propensity score matching. Results. Among 925 LT recipients, 406 were blood group A, 94 group B, 380 group O, and 45 group AB. On multivariable analysis, group A was associated with tumor recurrence (hazard ratio [HR] = 1.574 [95% confidence interval; 95% CI = 1.034-2.394] P = 0.034). After propensity score matching, 1- and 5-y recurrence rates were 7.4% and 20.1% in group A recipients versus 3.3% and 13.2% in non-A recipients (HR = 1.66 [95% CI = 1.12-2.45], P = 0.011). One and 5-y recurrence-free survivals were 85.2% and 66.8% in group A recipients versus 88.5% and 71.3% in non-A recipients (HR = 1.38 [95% CI = 1.01-1.90], P = 0.045). Among recipients within Milan criteria (n = 604), 1- and 5-y recurrence rates were 5.8% and 12.7% in group A recipients versus 3.1% and 12.2% in non-A recipients (HR = 1.197 [95% CI = 0.721-1.987], P = 0.485). Among recipients outside Milan criteria (n = 182), 1- and 5-y recurrence rates were 12.1% and 43.8% in group A recipients versus 3.9% and 15.6% in non-A recipients (HR = 3.175 [95% CI = 1.526-6.608], P = 0.002). Conclusions. ABO blood system influences the oncological outcome of recipients undergoing LT for HCC. Its incorporation in the prognostication model of LT for HCC may allow improving the management of LT candidates.
Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children.

BACKGROUND Children with human immunodeficiency virus type 1 (HIV-1) infection have limited options for effective antiretroviral treatment (ART). METHODS We conducted an open-label, randomized, noninferiority trial comparing three-drug ART based on the HIV integrase inhibitor dolutegravir with standard care (non-dolutegravir-based ART) in children and adolescents starting first- or second-line ART. The primary end point was the proportion of participants with virologic or clinical treatment failure by 96 weeks, as estimated by the Kaplan-Meier method. Safety was assessed. RESULTS From September 2016 through June 2018, a total of 707 children and adolescents who weighed at least 14 kg were randomly assigned to receive dolutegravir-based ART (350 participants) or standard care (357). The median age was 12.2 years (range, 2.9 to 18.0), the median weight was 30.7 kg (range, 14.0 to 85.0), and 49% of the participants were girls. By design, 311 participants (44%) started first-line ART (with 92% of those in the standard-care group receiving efavirenz-based ART), and 396 (56%) started second-line ART (with 98% of those in the standard-care group receiving boosted protease inhibitor-based ART). The median follow-up was 142 weeks. By 96 weeks, 47 participants in the dolutegravir group and 75 in the standard-care group had treatment failure (estimated probability, 0.14 vs. 0.22; difference, -0.08; 95% confidence interval, -0.14 to -0.03; P = 0.004). Treatment effects were similar with first- and second-line therapies (P = 0.16 for heterogeneity). A total of 35 participants in the dolutegravir group and 40 in the standard-care group had at least one serious adverse event (P = 0.53), and 73 and 86, respectively, had at least one adverse event of grade 3 or higher (P = 0.24). At least one ART-modifying adverse event occurred in 5 participants in the dolutegravir group and in 17 in the standard-care group (P = 0.01). CONCLUSIONS In this trial involving children and adolescents with HIV-1 infection who were starting first- or second-line treatment, dolutegravir-based ART was superior to standard care. (Funded by ViiV Healthcare; ODYSSEY ClinicalTrials.gov number, NCT02259127; EUDRACT number, 2014-002632-14; and ISRCTN number, ISRCTN91737921.).
Letter to the Editor on Bil et al. 2021 “Risk Assessment of Per‐ and Polyfluoroalkyl Substance Mixtures: A Relative Potency Factor Approach”

Ivonne M. C. M. Rietjens, Merijn Schriks,* Corine J. Houtman, Milou M. L. Dingemans, and Annemarie P. van Wezel Division of Toxicology, Wageningen University and Research, Wageningen, The Netherlands Vitens N.V. Water Company, Zwolle, The Netherlands The Water Laboratory, Haarlem, The Netherlands KWR Water Research Institute, Nieuwegein, The Netherlands Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands
The evolving classifications and epidemiological challenges surrounding chronic migraine and medication overuse headache: a review

Changes in diagnostic criteria, for example, the various International Classification of Headache Disorders criteria, would lead to changes in the outcomes of epidemiological studies. International Classification of Headache Disorders-1 was based mainly on expert opinion, yet most of the diagnostic criteria were reliable and valid, but it did not include chronic migraine. In its second version, the classification introduced chronic migraine, but this diagnosis resembled more a high-frequency migraine rather than the actual migraine transformation process. It also introduced medication overuse headache, but it necessitated analgesic withdrawal and subsequent headache improvement to be diagnosed as such. Hence patients having medication overuse headache could only be diagnosed in retrospect, which was an awkward situation. Such restrictive criteria for chronic migraine and medication overuse headache omitted a high proportion of patients. International Classification of Headache Disorders-3 allows a diagnosis of medication overuse headache due to combination analgesics if taken for at least 10 days per month for more than three months. Hence the prevalence rate of medication overuse headache and chronic migraine can increase compared to the previous version of the headache classification. Different criteria have been used across studies to identify chronic migraine and medication overuse headache, and therefore the information acquired from previous studies using earlier criteria becomes uncertain. Hence much epidemiological research would need to be interpreted cautiously or repeated with the most updated criteria, since the subjects in studies that apply the latest criteria may be phenotypically different from those in older studies.
Radiology During the COVID-19 Pandemic: Mapping Radiology Literature in 2020.

OBJECTIVES Our aim was to assess articles published in the field of radiology, nuclear medicine, and medical imaging in 2020, analyzing the linkage of radiology-related topics with coronavirus disease 2019 (COVID-19) through literature mapping, along with a bibliometric analysis for publications. METHODS We performed a search on Web of Science Core Collection database for articles in the field of radiology, nuclear medicine, and medical imaging published in 2020. We analyzed the included articles using VOS viewer software, where we analyzed the co-occurrence of keywords, which represents major topics discussed. Of the resulting topics, literature map created, and linkage analysis done. RESULTS A total of 24,748 articles were published in the field of radiology, nuclear medicine, and medical imaging in 2020. We found a total of 61,267 keywords, only 78 keywords occurred more than 250 times. COVID-19 had 449 occurrences, 29 links, with a total link strength of 271. MRI was the topic most commonly appearing in 2020 radiology publications, while "computed tomography" has the highest linkage strength with COVID-19, with a linkage strength of 149, representing 54.98% of the total COVID-19 linkage strength, followed by "radiotherapy, and "deep and machine learning". The top cited paper had a total of 1,687 citations. Nine out of the 10 most cited articles discussed COVID-19 and included "COVID-19" or "coronavirus" in their title, including the top cited paper. CONCLUSION While MRI was the topic that dominated, CT had the highest linkage strength with COVID-19 and represent the topic of top cited articles in 2020 radiology publications.
Hypofractionated Hybrid Radiotherapy Techniques for Synchronous Bilateral Breast Cancer

Objective: This study intends at a dosimetric comparison of four different hybrid plans which is a combination of different radiation therapy techniques, for synchronous bilateral breast cancer (SBBC) irradiation using a hypofractionated dose regimen. Methods: Four different hybrid techniques: 3DCRT+IMRT, 3DCRT+VMAT, IMRT+VMAT, and VMAT+IMRT were planned using computed tomography (CT) images of fifteen SBBC patients. All hybrid plans were generated using a hypofractionated dose prescription of 40.5 Gy in 15 fractions. 70% of the dose was planned with a base-dose component and the remaining 30% of the dose was planned with a hybrid component. The plans were evaluated based on the PTV and organs at risk (OARs) dosimetric parameter results and computed a plan quality score for each plan. Results: The results for PTV parameters have shown that the 3DCRT+VMAT and 3DCRT+IMRT plans were better than other plans. The 3DCRT±IMRT plan was provided better results for OARs, while IMRT±VMAT and VMAT+IMRT plans were increased the low dose volumes to the heart and lungs. The 3DCRT+VMAT plan was required less monitor units and treatment time compared to other plans. Conclusion: The overall plan quality score that integrated the dosimetric parameters of PTV and OARs indicated that the 3DCRT+VMAT hybrid plan is superior for SBBC treatment.
Effectiveness of Ultrasound-Guided Versus Anatomic Landmark–Guided Corticosteroid Injection on Pain, Physical Function, and Safety in Patients With Subacromial Impingement Syndrome

Objective The aim of the study was to compare the efficacy and safety of ultrasound-guided versus anatomic landmark–guided corticosteroid injection for the treatment of subacromial impingement syndrome. Design PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, Scopus, ClinicalTrials.gov, CBM, CNKI, and Wanfang databases were searched from inception to August 15, 2021, for randomized controlled trials comparing ultrasound-guided versus anatomic landmark–guided injections of corticosteroids for the treatment of subacromial impingement syndrome. Results Twelve randomized controlled trials with 891 patients were included in this study; 454 patients received ultrasound-guided injections and 437 received anatomic landmark–guided injections. Pooled results showed that ultrasound-guided injection was more beneficial for pain relief (10 trials; mean difference = −0.58; 95% confidence interval = −1.05 to −0.10; P = 0.017) and functional improvement (11 trials; standard mean difference = −0.84; 95% confidence interval = −1.41 to −0.27; P = 0.004). There was no significant difference in shoulder range of motion. In the subgroup analysis, there was a significant difference in pain relief and functional improvement at 6–8 wks and with methylprednisolone. Conclusions Ultrasound-guided injection of corticosteroids is potentially superior to anatomic landmark–guided injection in improving the clinical symptoms of subacromial impingement syndrome; however, these findings should be interpreted with some caution as the quality of evidence was rated as moderate to very low.
Co-Occurring Substance Use Disorders and Grief during Recovery

Abstract Background Individuals with substance use disorders (SUDs) often experience loss and grief when recovering from addiction. With fatal overdoses and suicide rates increasing for individuals with SUDs and other mental health concerns, individuals in recovery are often faced with mourning the loss of a loved one while navigating their life in recovery. The loss of a loved one can be compounded by the effect of losing their relationship with their drug of choice. These co-occurring losses may prove overwhelming during recovery and precipitate a relapse. Objectives We wish to propose the use of two bereavement models to address the grief present for individuals with SUDs experiencing loss so that providers are better able meet the complex needs of this population. Methods This article presents two separate bereavement models that may be used to shape treatment for individuals in recovery from addiction with co-occurring grief from the loss of a loved one: the dual-process model of coping with bereavement (DPM) and the two-track model of bereavement. Results We propose the application of these two grief models in treatment for individuals with SUDs who are experiencing co-occurring grief issues. We discuss therapeutic interventions that may be utilized to support clients with co-occurring losses. Conclusion/Importance: If an individual experiences the loss of a loved one while navigating their life in recovery from a SUD, they can experience complicated grief due to co-occurring losses. These models provide an opportunity for mental health providers to help those with SUDs work through this complex grief.
The flagellar germ‐line hypothesis: How flagellate and ciliate gametes significantly shaped the evolution of organismal complexity

This essay presents a hypothesis which contends that the development of organismic complexity in the eukaryotes depended extensively on propagation via flagellated and ciliated gametes. Organisms utilizing flagellate and ciliate gametes to propagate their germ line have contributed most of the organismic complexity found in the higher animals. The genes of the flagellum and the flagellar assembly system (intraflagellar transport) have played a disproportionately important role in the construction of complex tissues and organs. The hypothesis also proposes that competition between large numbers of haploid flagellated male gametes rigorously conserved the functionality of a key set of flagellar genes for more than 700 million years. This in turn has insured that a large set (>600) of highly functional cytoskeletal and signal pathway genes is always present in the lineage of organisms with flagellated or ciliated gametes to act as a dependable resource, or “toolkit,” for organ elaboration. Also see the video abstract here: https://youtu.be/lC5nC-WOcm8
Current and Speed Control Operating Modes of a Reaction Wheel

This paper presents some approaches to the design and some experimental results for current and speed control loops of a reaction wheel (RW). Reaction wheels are largely employed in satellite attitude control due to its large range of torque capability, small power consumption and high reliability. However, to achieve such performance the RW design shall deal with several restrictions, such as to support the space environment hazards (radiation, vacuum, high and fast temperature variation), and launch requirements (vibration, noise and choke). In this work some experimental results of an air-bearing table attitude control equipped with a Fiber Optics Gyro (FOG), a reaction wheel and a small fan will be presented. The RW is controlled by speed reference, and a second speed mode control similar to the first one was implemented in an external computer. Both were then compared by means of the air-bearing attitude control performance during the wheel zero-speed crossing. The results showed that the controllers have similar performance, as expected, and the maximum attitude pointing error remained below 0.08 degrees, which complies with the attitude requirements of Earth pointing satellites.
Hazardous alcohol consumption and problem drinking in Norwegian and Russian women and men: The Tromsø Study 2015–2016 and the Know Your Heart study 2015–2018

Aim: Harmful use of alcohol is a worldwide public health concern. Cultural differences may affect responses to questions on alcohol problems, making international comparisons difficult. We aimed to compare self-reported alcohol consumption and problem drinking between Norwegian and Russian populations. Methods: We used data from women and men aged 40–69 years participating in the Tromsø Study seventh survey (Tromsø7, N=17646, participation 65%), Tromsø (2015–2016), Norway, and the Know Your Heart study (KYH, N=4099, participation 51%), Arkhangelsk and Novosibirsk (2015–2018), Russia. Alcohol consumption and problem drinking were measured by the Alcohol Use Disorders Identification Test (AUDIT) via questionnaires (Tromsø7) and interviews (KYH). We compared AUDIT scores and components between populations, by sex. Results: Non-drinking was more commonly reported in KYH compared with Tromsø7 (men 15.5% versus 4.9%, women 13.3% versus 7.3%). In men, hazardous consumption (41.4% versus 31.5%) and problem drinking (24.8% versus 19.6%) was higher in KYH compared with Tromsø7, but opposite for women (6.5% versus 12.0%, and 2.3% versus 5.8%). KYH men were less likely to report problem drinking behaviours than Tromsø7 men, with the exception of needing a drink first thing in the morning (13.2% versus 2.4%). KYH women consistently reported less consumption and problem drinking than Tromsø7 women. Conclusions: We found between-study differences in hazardous drinking, but in men these were lower than suggested by differences in country-level statistics on alcohol consumption and alcohol-related health-harms. Study sample selection, stronger social desirability bias effects in the Russian samples, and cultural differences in responding could have affected the results.
Computer-assisted mitotic count using a deep learning–based algorithm improves interobserver reproducibility and accuracy

The mitotic count (MC) is an important histological parameter for prognostication of malignant neoplasms. However, it has inter- and intraobserver discrepancies due to difficulties in selecting the region of interest (MC-ROI) and in identifying or classifying mitotic figures (MFs). Recent progress in the field of artificial intelligence has allowed the development of high-performance algorithms that may improve standardization of the MC. As algorithmic predictions are not flawless, computer-assisted review by pathologists may ensure reliability. In the present study, we compared partial (MC-ROI preselection) and full (additional visualization of MF candidates and display of algorithmic confidence values) computer-assisted MC analysis to the routine (unaided) MC analysis by 23 pathologists for whole-slide images of 50 canine cutaneous mast cell tumors (ccMCTs). Algorithmic predictions aimed to assist pathologists in detecting mitotic hotspot locations, reducing omission of MFs, and improving classification against imposters. The interobserver consistency for the MC significantly increased with computer assistance (interobserver correlation coefficient, ICC = 0.92) compared to the unaided approach (ICC = 0.70). Classification into prognostic stratifications had a higher accuracy with computer assistance. The algorithmically preselected hotspot MC-ROIs had a consistently higher MCs than the manually selected MC-ROIs. Compared to a ground truth (developed with immunohistochemistry for phosphohistone H3), pathologist performance in detecting individual MF was augmented when using computer assistance (F1-score of 0.68 increased to 0.79) with a reduction in false negatives by 38%. The results of this study demonstrate that computer assistance may lead to more reproducible and accurate MCs in ccMCTs.
Collecting Distributed Knowledge For Community’s Smart Changes

The paper deals with the role of ICT in innovating government’s and the whole process of “policy production process”. By enhancing the connections between various governmental and social organizations, ICT supported knowledge flow s and the associated Socio Technical System may be a vehicle to support innovation in the public sector. In fact, they would enable governments to better cope with the uncertainties of a complex environment. The MIDA Project carried out in the territory of Asti Province (Piedmont) can be considered as an attempt to engage in building such as a system. The Project uses a crowd sourcing approach and it involves citizens in collecting data concerning broadband coverage, Internet access and usages. From a research standpoint, MIDA represented an opportunity to test the role of Internet as a dynamic collaborative environment where statistically relevant data and interpreted information could be merged. In terms of policy, the project stood as an opportunity for the local government to engage itself in a new policy approach to grasp people’s needs and improve service delivery. The paper deals with the role of ICT in innovating government’s and the whole process of “policy production process”. By enhancing the connections between various governmental and social organizations, ICT supported knowledge flow s and the associated Socio Technical System may be a vehicle to support innovation in the public sector. In fact, they would enable governments to better cope with the uncertainties of a complex environment. The MIDA Project carried out in the territory of Asti Province (Piedmont) can be considered as an attempt to engage in building such as a system. The Project uses a crowd sourcing approach and it involves citizens in collecting data concerning broadband coverage, Internet access and usages. From a research standpoint, MIDA represented an opportunity to test the role of Internet as a dynamic collaborative environment where statistically relevant data and interpreted information could be merged. In terms of policy, the project stood as an opportunity for the local government to engage itself in a new policy approach to grasp people’s needs and improve service delivery. Normal 0 14 false false false IT X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:. 0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Calibri","sans-serif";}