Miracle-dz/UniFAR-FTUs huggingface dataset:
Exercise electrocardiography and computed tomography coronary angiography: use of combined functional and anatomical testing in stable angina pectoris.

Coronary artery disease (CAD) is the leading cause of death in the United States in both men and women (1). It is therefore crucial to have optimal diagnostic modalities for diagnosis, prognostication and follow up of CAD patients. Coronary computed tomography angiography (CCTA) is advantageous in its ability to delineate coronary anatomy, including evaluation of the arterial lumen and surrounding atherosclerotic plaque to identify presence and severity of CAD. CCTA also allows evaluation of plaque composition and identifying those with high risk features (2). In addition, the inference of the physiologic, flow-limiting significance of anatomically detected lesions is possible, further aiding clinical decision making for physicians (3-5). Studies that have investigated the usefulness of CCTA in evaluation of acute chest pain found that patients seen in the emergency department for symptoms suggestive of acute coronary syndrome had reduced length of stay and were admitted less frequently when evaluated with CCTA, in comparison to standard care (6). The PROMISE trial showed that CCTA is an alternative to standard care in evaluation of patients in an outpatient setting with chest pain. When compared with functional testing such as exercise electrocardiography (ECG), nuclear stress testing, or stress echocardiography, anatomical testing with CCTA was found to have similar clinical outcomes (7). The CRESCENT trial also showed that CCTA is a cost-effective and safe alternative to functional testing, which included exercise ECG, nuclear stress testing, and stress echocardiography (8). In fact, a contemporary systematic review and meta-analysis of over 20,000 patients determined that, compared with functionalstress testing, CCTA was associated with reduced incidence of myocardial infarction (9). The SCOT-HEART trial studied the added value of CCTA compared to standard care, which composed primarily of exercise stress ECG testing, in patients with stable angina pectoris (10). Patients with CCTA were found to have lower rates of composite end point of death from CAD or nonfatal myocardial infarction (MI) at 5 years (2.3% vs. 3.9%). The composite end point was primarily driven by nonfatal MI; this may be due to the additional information from CCTA leading to better targeting of patients for preventative care. Patients with evidence of any CAD on CCTA, whether obstructive or nonobstructive, were prescribed preventative therapies. This is in comparison to the standard therapy, where patients with an ASSIGN score (11) of ≥20 were prompted to be prescribed Editorial Commentary
Using Thermally Crosslinkable Hole Transporting Layer to Improve Interface Characteristics for Perovskite CsPbBr3 Quantum-Dot Light-Emitting Diodes

In this paper, a thermally crosslinkable 9,9-Bis[4-[(4-ethenylphenyl)methoxy]phenyl]-N2,N7-di-1-naphthalenyl-N2,N7-diphenyl-9H-fluorene-2,7-diamine (VB-FNPD) film served as the hole transporting layer (HTL) of perovskite CsPbBr3 quantum-dot light-emitting diodes (QD-LEDs) was investigated and reported. The VB-FNPD film crosslinked at various temperatures in the range of 100~230 °C followed by a spin-coating process to improve their chemical bonds in an attempt to resist the erosion from the organic solvent in the remaining fabrication process. It is shown that the device with VB-FNPD HTL crosslinking at 170 °C has the highest luminance of 7702 cd/m2, the maximum current density (J) of 41.98 mA/cm2, the maximum current efficiency (CE) of 5.45 Cd/A, and the maximum external quantum efficiency (EQE) of 1.64%. Our results confirm that the proposed thermally crosslinkable VB-FNPD is a candidate for the HTL of QD-LEDs.
Defining the genetic profile of endometriosis

Endometriosis is a pathological condition which has been extensively studied, since its pathophysiology stems from a broad spectrum of environmental influences and genetic factors. Familial studies aim at defining inheritance trends, while linkage analysis studies focus on the identification of genetic sites related to endometriosis susceptibility. Genetic association studies take into account candidate genes and single nucleotide polymorphisms, and hence target at unraveling the association between disease severity and genetic variation. The common goal of various types of studies is, through genetic mapping methods, the timely identification of therapeutic strategies for disease symptoms, including pelvic pain and infertility, as well as efficient counselling. While genome-wide association studies (GWAS) play a primary role in depicting genetic contributions to disease development, they entail a certain bias as regards the case-control nature of their design and the reproducibility of the results. Nevertheless, genetic-oriented studies and the implementation of the results through clinical tests, hold a considerable advantage in proper disease management. In this review article, we present information about gene-gene and gene-environment interactions involved in endometriosis and discuss the effectiveness of GWAS in identitying novel potential therapeutic targets in an attempt to develop novel therapeutic strategies for a better management and treatment of patients with endometriosis.
Long-term changes in the abundance and breeding success of raptors and ravens in periods of varying management of a Scottish grouse moor

Management of heather moorland for driven Red Grouse (Lagopus lagopus scotica) shooting in the British uplands may benefit some raptors by reducing predation risk, especially when breeding, and by increasing food availability. We describe changes in abundance and breeding success of four raptor species and Common Raven (Corvus corax) during a 27-year study on a grouse moor in southwest Scotland in relation to whether or not the moor was managed by gamekeepers. Ground-nesting raptors, Hen Harrier (Circus cyaneus) and Merlin (Falco columbarius), increased during periods of grouse moor management and had a higher proportion of successful nesting attempts. Predation was the main apparent cause of breeding failure. In contrast, grouse moor management did not influence either abundance or breeding success of tree- and crag-nesting species, i.e., Peregrine (Falco peregrinus), Common Buzzard (Buteo buteo), and Raven. Buzzard sightings increased during the study, in line with their national recovery, whereas Peregrine and Raven showed little change in abundance. The results of our study highlight that management for Red Grouse can benefit both Hen Harrier and Merlin. However, on a UK scale these benefits to Hen Harriers, but not Merlin, are outweighed by their illegal killing, caused by fears that their consumption of Red Grouse can undermine the economics of grouse moor management.
Proliferative Activities of Benguet Legume Cultivars on a Breast Epithelial Cell Line

Legumes are extensively cultivated around the globe for human consumption and may contain potential estrogenic activities that interfere with normal physiology and pathophysiology. However, different cultivars grown in different regions of the world have different activities that may provide different nutritional value. Hence, in this study, legume cultivars from Benguet, a major source of legumes and other highland vegetables in Northern Philippines, were evaluated for their proliferative effects in the breast epithelial cancer cell line MCF7. Ethyl acetate extracts from Phaseolus vulgaris L. and Vigna unguiculata (L.) Walp. , but not from Tamarindus indica L. and Pisum sativum L. , induced slight proliferative effects on MCF7 cells at a low dose but reduced cell number at a higher dose. The proliferative effect of the extracts is likely estrogen receptor (ER)-dependent, as the same legume extracts only displayed inhibitory effects in the ER-negative MDA-MB-231 cells. Similar proliferative effects of P. vulgaris and V. unguiculata ethyl acetate extracts were reflected in their similar HPLC profiles, which is distinct from the HPLC profile of the T. indica ethyl acetate extract. Overall, our findings show that certain legumes from Benguet have slight proliferative activities in MCF7 cells, implying their potential estrogenic activities.
Examining Land Use/Land Cover Change and the Summertime Surface Urban Heat Island Effect in Fast-Growing Greater Hefei, China: Implications for Sustainable Land Development

In this study, a retrospective analysis of the relationship between the land use/land cover (LULC) change and associated surface urban heat island (SUHI) effect in fast-growing Greater Hefei between 1995 and 2016 was performed. Our results reveal the heterogeneous patterns of LULC change. The concentric buffer-based urban–rural gradient analysis reveals that most of the newly emerging developed land occurred within downtown Hefei. In contrast, in three suburban municipality/county jurisdictions, the overall area change in the non-developed land was much lower, but the net increase in developed land is remarkable. Meanwhile, the spatiotemporal patterns of SUHI are in good agreement with that of the developed land, as evidenced by the notable increase in SUHI intensity (SUHII) levels and SUHI spatial extent (SUHISE) in response to the rapid urban expansion, particularly along transportation corridors. In addition, partial least square regression (PLSR) models indicate that the buffer-based predictors/independent variables are significantly related to the responses (SUHII and SUHISE), explaining approximately 61.3% of the variance in the SUHII and 79.8% of the variance in the SUHISE, respectively. Furthermore, the relative strength of the independent variables in determining the relationship was quantitatively examined. The findings of this study provide clear evidence for decision making for sustainable land development and mitigation of the SUHI effect.
Effects of Reflective Inquiry Teaching Method on Students’ Retention Ability in Domestic Installation Module in Technical Colleges of Yobe State, Nigeria

The aim of this study was to assess the effects of reflective inquiry teaching method on students’ retention ability in domestic installation module in technical colleges of Yobe State, Nigeria. In guiding the study, two research questions and two hypotheses were formulated in line with the specific objectives. A pretest – post test nonequivalent control group quasi experimental research design was adopted for the study. Four intact classes from 4 technical colleges were selected to give a sample size of 88. Domestic Installation Retention Test (DIRT) was used to generate data for the study. The instrument was validated by three validates from the department of Electrical Technology Education, Modibbo Adama University of Technology, Yola. To determine the reliability of the instrument, Cronchbach Alpha reliability method was used and a reliability coefficient of 0.84 was obtained. Mean statistic was used to answer the two research questions of the study while the two null hypotheses of the study were tested using t-test and ANCOVA at 0.05 level of significance. Findings of the study revealed among others that reflective inquiry teaching method enhances retention abilities in students when used in teaching domestic installation. It further revealed that male and female students’ retention in domestic installation was high when taught using reflective inquiry teaching method. The study concluded that using reflective inquiry teaching method to teach students of electrical installation and maintenance works trade in Yobe State enhances the students’ retention ability which is visible in the retention test scores. The study recommended among others that teachers should employ reflective inquiry teaching method while engaging students in more work that will enable them develop critical thinking abilities.
Effects of Hydroxyapatite Nanoparticles on Apoptosis and Invasion of Human Renal Cell Carcinoma 786-0 Cells

Renal cell carcinoma is the most common cancer of the kidney, and resistant to traditional therapies. The aim of this study is to investigate the effects of hydroxyapatite nanoparticles on human renal cell carcinoma 786-0 cells. Cell proliferation was assessed with an 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide(MTT) staining kit. The apoptosis assay was assessed with an FITC Annexin V Apoptosis Detection Kit. Caspase-3 and caspase-12 were detected by immunocytochemical staining and semi-quantitative RT-PCR. Cell wound healing assay was used to ensure cell motility. Matrigel invasion assay was analysed via transwell chambers. Our results showed that hydroxyapatite nanoparticles significantly reduced cell proliferation, invasion and induced apoptosis of 786-0 cells. The inhibiting action may have relation with up-regulated caspase-12, leading the cells to apoptosis. This study suggests that hydroxyapatite nanoparticles may be an effective and delivery system for renal cell carcinoma therapy.
The Relationship between Syntactic Complexity and Quality of Nmt Outputs: an Exploratory Study

: Propelled by automated translation technology, translators in the current times are in urgent need of more precise guidelines on the ramification of post-editing tasks. Set in English-Chinese pairs, this paper attempts to explore the relationship between syntactic complexity of source text (ST) and quality of Neutral Machine Translation (NMT) output. 40 sentences were extracted from two pieces of legal documents. Three groups were formed based on sentence length: the first group includes 20 sentences with 7-to-36-word length range, the second includes another 20 sentences with longer length ranging from 31 to 68 words, and the third comprises two previous groups as combined to test overall correlation. Syntactic Complexity Analyzer developed by Lu (2010) was adopted to measure the 40 sentences, which were then processed by two versions of free online NMT systems-Google Neural Machine Translation (GNMT) and Systran online translation tools. MT quality evaluation was carried out manually by counting errors at lexical and syntactic level. The overall results suggest a small-to-medium effect size from ST syntactic complexity for NMT quality regardless of different NMT systems, and T-unit-related complexity measurements, mean length of T-unit (MLT) in particular, account for most such correlation. Also, whereas GNMT output quality at lexical level scores significantly higher than that of Systran, error scoring for both systems at syntactic level does not vary significantly.
Evaluation of Shearlet-based Superiorization with ART

In computerized tomography (CT) it is desired to reduce the x-ray dose, but when using reconstruction algorithms the amount of constraint-compatible solutions increases with the decrease of measurements. One approach to solve the reconstruction problem is the recently-developed superiorization methodology. It is an automated procedure that takes an iterative and perturbation resilient algorithm and creates an algorithm that produces constraint-compatible solutions that are superior according to some secondary criterion. The proposed secondary criterion used in this thesis is based on the shearlet transform, which provides optimally sparse approximations for images with anisotropic features and piecewise C2 singularity curves with bounded curvature. As a result the minimization of the l1-norm of the shearlet transform aims to make tissues like brain tumors better visible. The goal in this thesis is to evaluate the efficacy of the superiorization of the Algebraic Reconstruction Technique (ART) with secondary criteria based on the Total Variation (TV) and the l1-norm of the shearlet transform. The proposed secondary criterion is based on the proximal operator of the l1-norm of the shearlet transform. The experiments conclude that for ART the proposed proximal operator variation of the shearlet-based superiorization performs better than the previous shearlet-based superiorization but it does not outperform the TV based superiorization according to the Image-wise Region of Interest (IROI) metric.
Water-Related Payment Schemes for Forest Ecosystem Services in Selected Southeast European (SEE) Countries

This paper examines the level of payment for ecosystem services (PES) concept implementation in the financing of water-related forest ecosystem services (ES) in the Republic of Croatia, the Federation of Bosnia and Herzegovina (FB&H), the Republic of Slovenia, and the Republic of Serbia. The focus is on water-related forest ES recognised by the millennium ecosystem assessment (MEA). For the purpose of this paper, the term pure PES describes schemes that comply to all five conditions set by Wunder definition and term PES like for those schemes that miss some of those conditions. In the first step, the most important legislative documents related to forests, water, and environmental protection were selected. The second consists of a content analysis; focusing on the definition of ES; the definition of fees or payments; the establishment of ‘forest funds’, ‘water funds’, or ‘environmental funds’; and the way these funds were spent. Here we looked at the flow of funding into the forestry sector recognising forest management as the main water-related forest ES provider. Research revealed existence of well-established payments schemes in forestry in Croatia for almost 30 years and in FB&H for some 20 years which were assessed as closest to pure PES. In Serbia and Slovenia, there were no PES or PES like schemes in the forestry sector. In the water sector the well-established PES like payments schemes existing in all four countries. The environmental protection sector, however, rely more on the tax like rather than on the PES like schemes. Legislation in general recognised the link between forests and water, but this was much more evident in the forestry than in the water or environment sector. The role of the state is strongly pronounced in all countries studied, and was the main driving force behind all payments. However, this position of the state represents also the main obstacle for the development of pure PES schemes, together with underdeveloped private forestry and complex socio-economic conditions. Nevertheless, there is room for further development of pure PES and PES like schemes based on EU or global experiences.
Invited Review Tumor heterogeneity: morphological, molecular and clinical implications

Malignant tumors are characterized by their great heterogeneity and variability. There are hundreds of different types of malignant tumors that harbour many oncogenic alterations. The tumor heterogeneity has important morphological, molecular and clinical implications. Except for some hematopoietic and lymphoproliferative processes and small cell infant tumors , there are not specific molecular alterations for most human tumors. In this review we summarize the most important aspects of carcinogenesis and chemoradiosensitivity of malignant cells. In this regard, some oncogenes such as neu , ras and bcl-2 have been associated with cellular resistance to treatment with anticancer agents . The knowledge of oncogenic alterations involved in each tumor can be important to correlate the morphological features, the genetic background, the prognosis and the clinical response to treatment with anticancer agents. Based on the molecular background of the tumor there are new cancer gene therapy protocols. For example using adenovirus Ela in tumors with overexpression of neu oncogene, inhibitors of tirosine kinase specific for the PDGF receptor in glioma, inhibitors of farnesil transferase to prevent ras activity in tumors with mutations in the ras gene.
Prevalence and antimicrobial resistance of bacteria isolated from Beni-Guil lamb carcasses in eastern Morocco

This study aims to assess the microbial quality and antimicrobial resistance of bacteria isolated from Beni-Guil lamb carcasses. 103 samples were used for the study. The mean values obtained for microbial quality were 4.65, 3.07, 1.26, 0.99 and 0.69 (log10 CFU/cm), respectively for total aerobic Flora counts, Enterobacteriaceae, fecal coliform, Escherichia coli and Staphylococcus aureus.70% of tested Escherichia coli strains were resistant to gentamicin and ciprofloxacin, as for Staphylococcus aureus, 100% of strains tested were resistant to ciprofloxacin and sensitive to erythromycin. Regarding gentamicin and benzylpenicillin, 70 % and 60% of Staphylococcus aureus strains were resistant, respectively.
Effectiveness and Efficiency of Solid Waste Services in Lagos State, Nigeria

Lagos is the largest producer of municipal solid waste in Nigeria, yet it is the smallest of Nigeria’s 36 states with the highest projected population, highest level of urbanization and it houses Nigeria’s largest chief port, and principal economic and cultural centres. Out of the total waste generated, only about 73 percent actually got to the final disposal site. There is a possibility of inefficient and ineffective municipal solid waste management system in place which can damage the ecosystem services, contaminate ground and surface water, creates greenhouse gas emissions, increase disease transmission, damages ecosystem services and discourages tourism and other businesses. To this end, this study analysed the efficiency and effectiveness of solid waste services and; the efficiency and effectiveness of solid waste services in Lagos State using primary data and conducting statistical tests. The study found a general agreement on what constitutes efficient and effective solid waste services. However, the study concluded that the waste management system in Lagos State is inefficient, ineffective and therefore; unsustainable. The study therefore recommends among others the urgent need to re-organize the waste management institutions for effective and efficient performance. This requires substantial planning ability, appropriate equipment and continuous managerial optimization of vehicles and workers productivity, efficient vehicle routing, better designed vehicles, managerial incentives, faster vehicle repairs, vehicle standardization.
Electron. Commun. Probab. 23 (2018), no. 41, https://doi.org/10.1214/18-ECP147

In this paper, we obtain upper and lower bounds for the moments of the solution to a class of fractional stochastic heat equations on the ball driven by a Gaussian noise which is white in time and has a spatial correlation in space of Riesz kernel type. We also consider the space-time white noise case on an interval.
Response of Pigeonpea and Soybean to Planting Patterns and Weed Control Measures

A tield experiment conducted during kharif seasons of 1989–90 and 1991–92 at IGKYY Zonal Agricultural Research Station, Ambikapur (M. P.) revealed that paired row planting of arhar+three rows of soybean gave significantly higher arhar equivalent yield and harvest index as compared with sole crops of arhar and soybean. Soybean as an intercrop reduced the arhar yield. The lowest yield of arhar was recorded with arhar paired rows at 30 cm and three rows of soybean. whereas the highest yield was obtained with arhar paired rows at 30 cm. Two hand wcedings at 20 and 40 DAS gave significantly higher arhar equivalent yield and harvest index than the application of tluchloralin 1.5 kg per ha as pre-sowing soil incorporation. Planting patterns of arhar + soybean recorded significantly higher harVest index and less weed biomass/sq. m than the sole arhar and soybean plantings.