Miracle-dz/UniFAR-FTUs huggingface dataset:
Technical and Economic Feasibility Studies of a Micro Hydropower Plant in Cameroon for a Sustainable Development

All serious projects over the world should respect the objectives of sustainable development. The contribution of every country against the climate change is request applied. The development of renewable energies is an effective contribution to solutions for this relevant question. Hydropower energy is one of most promising clean energy technologies. However, Micro Hydro Power Plants (MHPP) will be more promising than large hydro power stations. Cameroon has a great hydroelectric potential, but the access rate to electricity is still very low in rural areas of this country. The objective of this work is to do the technical and economic assessment of a MHPP in BAKASSA, which is a remote village in the West Region of Cameroon, in the intention to contribute to its sustainable development. The results of this study show that this MHPP project can be developed with installed power of 97 kW, where the Francis turbine is recommended. The investment cost evaluated at 88,440,068 FCFA. It is a profitable project with a maximum payback period of 9 years.
Periodontal Healing after Lower Third Molars Extraction: A Clinical Evaluation of Different Flap Designs

Periodontal healing after third molars extraction seems to be influenced by the choice of different flap techniques. The purpose of the present study was to assess the clinical condition of adjacent first and second molar sites, after the extraction of lower third molars, performed through different flap designs. Eighty patients, aged between 14 and 30 years, were analyzed for periodontal parameters of VPI, PPD, and CAL, pre-operatively (T0), after 15 days (T1), after 1 month (T2), and after 2 months (T3) from extraction. Techniques performed were trapezoidal flap (TRAP), marginal flap (MARG), flap with papilla detachment (DETP), and flap with papilla decapitation (DEC). No significant differences were found between the four flaps at each observation time and considering the interval between T0 and T3, for VPI, PPD at first molar site, PPD at second molar site, and CAL at second molar site. Significant variations for CAL were registered, for each flap, between T0 and T3, in all cases for buccal site, in three cases for buccal-distal site. After 2 months of follow-up, no strong evidence can be assumed for or against the use of a particular flap design for the extraction of lower third molars.
Single Cell Analysis of Cultivated Fibroblasts from Chronic Pancreatitis and Pancreatic Cancer Patients

Cancer-associated fibroblasts (CAFs) play a major role in the progression and drug resistance of pancreatic cancer. Recent studies suggest that CAFs exhibit functional heterogeneity and distinct transcriptomic signatures in pancreatic cancer. Pancreatic fibroblasts also form an integral component in pancreatic diseases such as chronic pancreatitis named disease-associated fibroblasts (DAFs). However, intra-tumoral heterogeneity of CAFs in pancreatic cancer patients and their pivotal role in cancer-related mechanisms have not been fully elucidated. Further, it has not been elucidated whether CAF subtypes identified in pancreatic cancer also exist in chronic pancreatitis. In this study, we used primary isolated fibroblasts from pancreatic cancer and chronic pancreatitis patients using the outgrowth method. Single-cell RNA sequencing (scRNA-seq) was performed, and bioinformatics analysis identified highly variable genes, including factors associated with overall survival of pancreatic cancer patients. The majority of highly variable genes are involved in the cell cycle. Instead of previously classified myofibroblastic (myCAFs), inflammatory (iCAFs), and antigen-presenting (ap) CAFs, we identified a myCAFs-like subtype in all cases. Most interestingly, after cell cycle regression, we observed 135 highly variable genes commonly identified in chronic pancreatitis and pancreatic cancer patients. This study is the first to conduct scRNAseq and bioinformatics analyses to compare CAFs/DAFs from both chronic pancreatitis and pancreatic cancer patients. Further studies are required to select and identify stromal factors in DAFs from chronic pancreatitis cases, which are commonly expressed also in CAFs potentially contributing to pancreatic cancer development.
Reintegration of former Boko Haram members and combatants in Nigeria: an interpretative phenomenological analysis of community members’ experiences of trauma

Abstract Reintegration in conflict settings poses significant challenges. In Nigeria, while much emphasis is placed on deradicalising and rehabilitating former Boko Haram members, including combatants and their families, the community seems to receive minimal priority concerning the traumatic experience they face and its impact on limiting reintegration. This paper makes an original contribution by using an interpretative phenomenological analytical lens to explore community members who are victims with lived experiences of trauma in conflict settings. The study draws on semi-structured interviews with 30 participants recruited from Bornu, Adamawa and Kaduna states. Based on the analysed data, the study found that trauma limits reintegration and fuels scepticism about the genuine reform of the former Boko Haram members and combatants. Trauma was also perceived to transcend the immediate victims and extend to the community. We recommend a trauma-informed cognitive behavioural therapy intervention to create a positive outlook that encourages reintegration and reduces potential recidivism.
Selective Expansion of NKG2C+ Adaptive NK Cells Using K562 Cells Expressing HLA-E

Adaptive natural killer (NK) cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs) can be expanded in vivo in response to human cytomegalovirus (HCMV) infection. Developing a method to preferentially expand this subset is essential for effective targeting of allogeneic cancer cells. A previous study developed an in vitro method to generate single KIR+ NK cells for enhanced targeting of the primary acute lymphoblastic leukemia cells; however, the expansion rate was quite low. Here, we present an effective expansion method using genetically modified K562-HLA-E feeder cells for long-term proliferation of adaptive NK cells displaying highly differentiated phenotype and comparable cytotoxicity, CD107a, and interferon-γ (IFN-γ) production. More importantly, our expansion method achieved more than a 10,000-fold expansion of adaptive NK cells after 6 weeks of culture, providing a high yield of alloreactive NK cells for cell therapy against cancer.
The Impact of Emotional Intelligence, Managerial Intelligence, and Transformational Leadership on Multidimensional Public Project Success

The project manager's role and influence on the project's overall outcome have fascinated many academicians, researchers, and practitioners. The project manager's leadership and human skills play a vital role in the project's outcome; therefore, it is imperative for these competencies to be identified, learned, and leadership styles to be adopted. This study aims to define the most relevant competencies to multidimensional project success and their interrelationship. The quantitative method was used by applying a survey to project managers and team members working in the public sector of Pakistan. The results suggest that a combination of emotional, managerial intelligence, and transformational leadership are stronger predictors of multidimensional public project success. This study has shown that management and leadership need to be integrated to achieve better results. Project managers need to combine soft and hard skills, leadership competencies, and management to engage with people and be effective in terms of processes, tasks, and objectives.
Increasing eggshell strength and fat-soluble vitamins content in yolk by including chestnut wood tannin in polyunsaturated fatty acid-enriched diet of young hens

Abstract The aim of the study was to evaluate the effect of tannins addition to hen diets on the performance and egg quality characterised by the physical characteristics, vitamin content and fatty acid composition of egg yolks. Two hundred and forty 18-week-old Lohmann Brown hens were assigned to three dietary treatments according to the supplementation of chestnut wood tannin (Castanea sativa Mill.; 0, 1 and 10 g/kg) to the diet. The fat source in the diets was rapeseed oil and extruded flaxseed that ensured higher polyunsaturated fatty acids (PUFAs) content in the feed. No effect of tannin addition on the performance characteristics of hens was observed. Both tannin addition treatments (1 and 10 g/kg) significantly increased the shell breaking strength (p = .050), shell thickness (p = .001), shell index (p = .006) and shell percentage (p = .002). The higher level of tannins (10 g/kg) in feed increased the deposition of α-tocopherol (p < .001), γ-tocopherol (p = .005) and retinol (p < .001) in the yolk. The cholesterol content and n-6/n-3 ratio in the yolk were not influenced by the level of tannins in the diet. A negative effect of tannins was detected in the fatty acid indexes. In conclusion, the inclusion of chestnut wood tannins in the hen diet rich in PUFAs improved eggshell quality, and higher dose of tannin (10 g/kg) increased the deposition of fat-soluble vitamins in the yolk without negatively affecting young hen performance. Highlights The tannins increased the eggshell quality and fat-soluble vitamins content in yolks. A dose of 1 g/kg chestnut wood tannins increased the eggshell quality. The increase in fat-soluble vitamins (α- and γ-tocopherol and retinol) content occurred after the addition of 10 g/kg chestnut wood tannins. The dietary tannins changed the levels of myristic, margaric, palmitoleic and eicosenoic fatty acids. Chestnut wood tannins did not affect the performance characteristics.
Anxiety and depression prevalence and their risk factors in lupus nephritis patients: A case–control study

Anxiety and depression exhibit a high prevalence in systemic lupus erythematosus (SLE) patients, while this issue is seldom explored in lupus nephritis (LN). Hence, the current study aimed to investigate the prevalence of anxiety and depression, and the risk factors for these mental disorders in LN patients.
How Did Work-Related Depression, Anxiety, and Stress Hamper Healthcare Employee Performance during COVID-19? The Mediating Role of Job Burnout and Mental Health

The study objective was to examine the psychological impact of the COVID-19 pandemic on the performance of healthcare employees. The study was informed by a theoretical framework that incorporates different psychological issues (i.e., stress, depression, and anxiety) that influence healthcare workers’ performance through the mediating roles of job burnout and mental health. The study data was gathered through structured questionnaires from 669 participants working in the healthcare sector in Pakistan. A structured equation modeling (SEM) technique was used for data analysis and hypothesis development. It was found that stress, depression, and anxiety positively affected healthcare employees’ job performance during COVID-19. Psychological factors had a positive and significant impact on job burnout and mental health. Job burnout and mental health mediated the relationship between stress, anxiety, depression, and employee performance. The ongoing repercussions of COVID-19 include their impact on employee performance in the healthcare sector. Healthcare worker performance is critical to fostering industrial economic growth. Elevated levels of stress, depression, and anxiety have profoundly exacerbated employee mental health issues. COVID-19 has created challenging working conditions in organizations requiring that they address the growing psychological issues which impact negatively on worker performance.
Combining Landsat 8 and Sentinel-2 Data in Google Earth Engine to Derive Higher Resolution Land Surface Temperature Maps in Urban Environment

Thermal infrared (TIR) satellite imagery collected by multispectral scanners is important to map land surface temperature on a global scale. However, the TIR spectral bands are typically available in coarser spatial resolution than other multispectral bands of shorter wavelengths. Therefore, the spatial resolution of the derived land surface temperature (LST) is limited to around 100 m. This constrains the applications of such thermal satellite sensors in which finer detail of LST spatial pattern is relevant, especially in an urban environment where the land cover structure is complex. Among the missions deployed on the Earth’s orbit, NASA’s TIRS sensor onboard Landsat 8 and Landsat 9, and ASTER onboard Terra provide the highest spatial resolution of the thermal band. On the other hand, ESA’s Sentinel-2 multispectral imagery is collected at a higher spatial resolution of 10 m with a 5-day temporal resolution, but scanning in the TIR band is not available. This study makes use of the known relationship between LST and land cover metrics, such as the normalized difference vegetation index (NDVI), built-up index (NDBI), and water index (NDWI). We define a multiple linear regression model based on the spectral indices and LST derived from Landsat 8 data to inform the same model in which the equivalent spectral indices derived from Sentinel-2 are used to predict LST at 10 m resolution. Results of this approach are demonstrated in a case study for Košice city, Slovakia, where the multiple linear model based on Landsat 8 data achieved an R2 of 0.642. The correlation between the observed Landsat 8 LST and predicted LST from Sentinel-2 aggregated to the same resolution as the observed LST was high (r = 0.91). Despite the imperfections of the downscaling model, the derived LST at 10 m resolution provides a better perception of the LST field that can be easily associated with land cover features present in urban environment. The LST downscaling approach was implemented into Google Earth Engine. It provides a user-friendly online application that can be used for any city or urban region for generating a more realistic spatial pattern of LST than can be directly observed by contemporary Earth observation satellites. The tool aids in urban decision making and planning on how to mitigate overheating of cities to improve the life quality of their citizens.
Diversity of Tick-Borne Pathogens in Tick Larvae Feeding on Breeding Birds in France

Birds play a role in maintaining tick-borne diseases by contributing to the multiplication of ticks and pathogens on a local scale during the breeding season. In the present study, we describe the diversity of tick and pathogen species of medical and veterinary importance in Europe hosted by 1040 captured birds (56 species) during their breeding season in France. Of the 3114 ticks collected, Ixodes ricinus was the most prevalent species (89.5%), followed by I. frontalis (0.8%), I. arboricola (0.7%), Haemaphysalis concinna (0.5%), H. punctata (0.5%), Hyalomma spp. (0.2%), and Rhipicephalus spp. (0.06%). Because they may be representative of the bird infection status for some pathogen species, 1106 engorged tick larvae were screened for pathogens. Borrelia burgdorferi sensu lato was the most prevalent pathogen genus in bird-feeding larvae (11.7%), followed by Rickettsia spp. (7.4%), Anaplasma spp. (5.7%), Babesia spp. (2.3%), Ehrlichia spp. (1.4%), and B. miyamotoi (1%). Turdidae birds (Turdus merula and T. philomelos), Troglodytes troglodytes, and Anthus trivialis had a significantly higher prevalence of B. burgdorferi s.l. -infected larvae than other pathogen genera. This suggests that these bird species could act as reservoir hosts for B. burgdorferi s.l. during their breeding season, and thus play an important role in acarological risk.
The Relationship between Depressive Symptoms, Loneliness, Self-Control, and Gaming Disorder among Polish Male and Female Gamers: The Indirect Effects of Gaming Motives

The present study analyzed the relationship between gaming disorder (GD), motives for gaming, and psychological problems in daily life (i.e., depression, loneliness, and self-control deficits) among Polish gamers. More specifically, the purpose of the present study was to analyze the indirect effects between GD and psychological problems in daily life via motives for gaming among male and female gamers. Additionally, the present study examined gender differences in motives for gaming and the relationship between the analyzed variables. The sample comprised 652 gamers (233 females; M = 28.77 years; SD = 7.18; age range: 18–48 years). The nine-item Internet Gaming Disorder Scale-Short Version (IGDS9-SF) was used to assess GD. The motives for gaming were assessed using the Motives for Online Gaming Questionnaire (MOGQ). The nine-item Patient Health Questionnaire (PHQ-9) was used to assess depressive symptoms, and the Brief Self-Control Scale (BSCS) was used to assess self-control. Loneliness was assessed using the De Jong Gierveld Loneliness Scale. In order to examine the relationship between the study variables, path analysis and indirect effects analysis were performed among both male and female gamers. The present study showed that depressive symptoms and self-control exerted a significant indirect effect on GD via escape and fantasy motives for gaming. Additionally, there was an indirect effect between depressive symptoms and GD via social motives for gaming. However, these indirect effects were found among male gamers only. The present study also showed gender differences in all analyzed gaming motives except escape (males scoring higher on all of them) and in the relationship between depressive symptoms and escape. These findings contribute to a better understanding of GD development mechanisms, which are associated with psychological problems in daily life.
Farm-to-School programmes, benefits, health outcomes and barriers: A structured literature review

Introduction: A common refrain in public health and medicine concerns the rapidly rising incidence of obesity and metabolic-like syndromes over the last two decades. A plethora of data suggests there are many roots to the issue and what to do about it. The rise of childhood obesity and the growing incidence of adult endocrine diseases like type 2 diabetes mellitus in paediatric populations are the most concerning. One of the solutions that aims to tackle health and food justice issues is the Farm-to-School programme (FTSP), which helps bring local fruit and vegetables (FVs) to schools and associated nutrition-related programmes. In the USA, a significant expansion of FTSPs has happened since the early 2000s. Numerous economic, social and nutritional benefits of these programmes have been documented, and various methodologies have been used to elucidate the benefits and barriers. Method: This paper reviews the multifaceted strengths of FTSPs including health, institutional and farm-related benefits. The paper also discusses federal- and state-level environment and the obstacles to FTSP implementation. Conclusion: FTSPs offer a comprehensive way to strengthen childhood nutrition education and stimulate local communities economically and socially. FTSPs increase the purchase of locally produced food items, resulting in higher incomes for small farmers. FTSPs have also increased community engagement and new opportunities for farming businesses. In sum, FTSPs can be considered a boon for local schools, producers, communities and better health outcomes for school-age children. Teaching children about food literacy could prove beneficial for supporting their self-efficacy regarding foods and encouraging lifetime healthy dietary behaviours.
Taylor‐vortex membrane reactor for continuous gas‐liquid reactions

A unique Taylor-vortex membrane reactor (TVMR) design for continuous gas – liquid reactions is presented in this work. The reactor consists of a cylindrical rotor inside a stationary concentric cylindrical vessel, and a flexible system of equispaced baffle rings surrounding the rotor. This restricts the annular cross section to a small gap between the baffles and the rotor, and divides the annulus into 18 mixing zones. The baffles support a 6 m long PFA tubular membrane that is woven around the rotor. At 4 mL/min inlet flow rate, the TVMR showed a plug-flow behavior and outperformed the unbaffled reactor, having 5 – 12 times lower axial dispersion. The continuous aerobic oxidation of benzyl alcohol was performed for 7 h using the Pd(OAc) 2 /pyridine catalyst in toluene at 100 (cid:1) C and 1.1 MPa oxygen pressure. A stable conversion of 30% was achieved with 85% benzaldehyde selectivity, and no pervaporation of organics into the gas phase.
Rotavirus C Replication in Porcine Intestinal Enteroids Reveals Roles for Cellular Cholesterol and Sialic Acids

Rotaviruses (RVs) are a significant cause of severe diarrheal illness in infants and young animals, including pigs. Group C rotavirus (RVC) is an emerging pathogen increasingly reported in pigs and humans worldwide, and is currently recognized as the major cause of gastroenteritis in neonatal piglets that results in substantial economic losses to the pork industry. However, little is known about RVC pathogenesis due to the lack of a robust cell culture system, with the exception of the RVC Cowden strain. Here, we evaluated the permissiveness of porcine crypt-derived 3D and 2D intestinal enteroid (PIE) culture systems for RVC infection. Differentiated 3D and 2D PIEs were infected with porcine RVC (PRVC) Cowden G1P[1], PRVC104 G3P[18], and PRVC143 G6P[5] virulent strains, and the virus replication was measured by qRT-PCR. Our results demonstrated that all RVC strains replicated in 2D-PIEs poorly, while 3D-PIEs supported a higher level of replication, suggesting that RVC selectively infects terminally differentiated enterocytes, which were less abundant in the 2D vs. 3D PIE cultures. While cellular receptors for RVC are unknown, target cell surface carbohydrates, including histo-blood-group antigens (HBGAs) and sialic acids (SAs), are believed to play a role in cell attachment/entry. The evaluation of the selective binding of RVCs to different HBGAs revealed that PRVC Cowden G1P[1] replicated to the highest titers in the HBGA-A PIEs, while PRVC104 or PRVC143 achieved the highest titers in the HBGA-H PIEs. Further, contrasting outcomes were observed following sialidase treatment (resulting in terminal SA removal), which significantly enhanced Cowden and RVC143 replication, but inhibited the growth of PRVC104. These observations suggest that different RVC strains may recognize terminal (PRVC104) as well as internal (Cowden and RVC143) SAs on gangliosides. Finally, several cell culture additives, such as diethylaminoethyl (DEAE)-dextran, cholesterol, and bile extract, were tested to establish if they could enhance RVC replication. We observed that only DEAE-dextran significantly enhanced RVC attachment, but it had no effect on RVC replication. Additionally, the depletion of cellular cholesterol by MβCD inhibited Cowden replication, while the restoration of the cellular cholesterol partially reversed the MβCD effects. These results suggest that cellular cholesterol plays an important role in the replication of the PRVC strain tested. Overall, our study has established a novel robust and physiologically relevant system to investigate RVC pathogenesis. We also generated novel, experimentally derived evidence regarding the role of host glycans, DEAE, and cholesterol in RVC replication, which is critical for the development of control strategies.