Miracle-dz/UniFAR-FTUs huggingface dataset:
The four pillars of HFrEF therapy: is it time to treat heart failure regardless of ejection fraction?

Abstract The syndrome of heart failure (HF) has historically been dichotomized based on clinical trial inclusion criteria into patients with a reduced or preserved left ventricular ejection fraction (LVEF) using a cut-off of above or below 40%. The majority of trial evidence for the benefits of disease-modifying pharmacological therapy has been in patients with HF with reduced ejection fraction (HFrEF), i.e. those with an LVEF ≤40%. Recently, the sodium-glucose co-transporter 2 inhibitors empagliflozin and dapagliflozin have been shown to be the first drugs to improve outcomes in HF across the full spectrum of LVEF. There is, however, growing evidence that the benefits of many of the neurohumoral modulators shown to be beneficial in patients with HFrEF may extend to those with a higher LVEF above 40% but still below the normal range, i.e. HF with mildly reduced ejection fraction (HFmrEF). Whether the benefits of some of these medications also extend to patients with HF and preserved ejection fraction (HFpEF) is an area of ongoing debate. This article will review the evidence for HF treatments across the full spectrum of LVEF, provide an overview of recently updated clinical practice guidelines, and address the question whether it may now be time to treat HF with some therapies regardless of ejection fraction.
Chromospheric jets: Possible extreme-ultraviolet observations of spicules

Stigmatic EUV spectra of chromospheric lines obtained by the Naval Research Laboratory High Resolution Telescope and Spectrograph (HRTS) show small arc second regions with strong (10-20 km s/sup -1/) Doppler shifts which we call ''chromospheric jets''. Because of the strong resemblance of their physical and statistical properties, such as temperature, density, velocity, size, and birthrate, to those of visible light spicules, it is highly likely that they are different manifestations of the same phenomena, although a one-to-one identification has not yet been made. The main difference is the 40 s lifetime of the chromophseric jets which is shorter than the 5 minute lifetime of visible light spicules. The chromospheric jets are found in the supergranular cell interiors where chromospheric and transition zone line intensities are weak. Data H.cap alpha. mottles found in the cell boundaries are well correlated with intense, symmetric chromospheric EUV line profiles and are only weakly related to the chromospheric jets.
Extended Formulation of the Second Law for Open Discrete Systems

En utilisant les quantites du hors equilibre dynamiques de temperature de contact, d'entropie molaire partielle et de potentiel chimique, on obtient une formulation etendue de l'inegalite de Clausius pour des systemes ouverts discrets en simulant les processus hors-equilibre
The Role of Fast Track Extubation in Enhance Recovery after Pediatric Cardiac Surgery

Background: By allowing patients to be extubated from their ventilators in the intensive care unit (ICU) as soon as they have stabilized, fast-track anesthesia (FTA) hastens the return to full awareness and independent breathing after surgery. Objective: In this study our main goa is to evaluate the role of fast track extubation in enhance recovery after pediatric cardiac surgery. Method: This prospective study was carried out at tertiary hospital from January 2021 from January 2022 where total of 200 CHD children, aged 6 months to 2 years and admitted to tertiary hospital, were selected for this study. During the study, 200 patients were randomly divided into two groups each consisting of 100 patients, and were subjected to fast track anesthesia and conventional anesthesia before surgeries. Results: During the study, in fast track anesthesia group mean age was 1.2 ± 0.5 years, followed by 55 cases were female, 47 were preterm patients, mean anesthesia times was 3.5 ± 1.2 h, mean surgery time was 295.1 ± 22.9 min, mean CPB time was 47.2 ± 11.8, mean block time or a total allocated amount of time for a surgeon was 30.2 ± 8.9. whereas in conventional anesthesia group, mean age was 1.1 ± 0.5 years, followed by 40 cases were female, 45 were preterm patients, mean anesthesia times was 3.2 ± 1.0 h, mean surgery time was 288.0 ± 20.5 min, mean CPB time was 46.2 ± 10.7, mean block time was 31.5 ± 9.1. in fast track group mean extubation time was 22.9 ± 3.5 min followed by mean postoperative hospital stay was 11.5 ± 3.0 days, besides that, at extubation SAS score was 3.8 ± 0.6a and 24h post operation SAS score was 4.0 ± 0.5. Whereas in conventional group mean extubation time was 189.1 ± 31.2 min followed by mean postoperative hospital stay was 16.1 ± 2.4, besides that, at extubation SAS score was 4.8 ± 0.7and 24h post operation SAS score was 3.9 ± 0.5. MAP, HR and CVP between children outcome was measured based different time interval (T0 to T5) Moreover, no significant changes were noticed between two group. The number of patients with ventilator-associated pneumonia was less in fast track group than in conventional group (P < 0.05). In fast track group arrhythmia cases were seen in 1% cases followed by 1% infection cases were seen, bleeding seen in 1%. Whereas in conventional group arrhythmia cases were seen in 2% cases followed by 1% infection cases were seen, bleeding seen in 2%. Conclusion: Fast Track Anesthesia generates stable hemodynamics during operation, shorter extubation time, shorter ICU and hospitalization stay without increase in adverse reactions. It is worthy of recommendation for clinical practice.
Rich in Phenolics—Strong Antioxidant Fruit? Comparative Study of 25 Strawberry Cultivars

Phenolic compounds of 25 newly introduced strawberry cultivars were profiled using spectrophotometry, electron paramagnetic resonance (EPR) spectroscopy, and high-performance liquid chromatography-mass spectrometry. Total phenolic and anthocyanin content (TPC and TACY, respectively), as well as vitamin C, and concentrations of individual phenolic compounds in fruits were evaluated to identify the most promising cultivars according to their phenolic profile. The highest values of TPC, TACY, and vitamin C were recorded in ‘Premy’ (1.53 mg eq GA g−1 FW), ‘Sandra’ (30.60 mg eq Pg-3-g 100 g−1 FW), and ‘Laetitia’ (56.32 mg 100 g−1 FW), respectively. The DPPH and •OH radicals scavenging activity of fruit methanolic extracts was estimated using EPR spectroscopy. All cultivars are almost uniformly effective in the scavenging of •OH radical, while ‘Tea’, ‘Premy’, and ‘Joly’ were marked as highly potent cultivars (over 70%) in terms of DPPH-antiradical activity. Specific peroxidase activities were the highest in ‘Garda’, ‘Federica’, and ‘Rumba’ (0.11, 0.08, and 0.06 U mg−1 prot, respectively). ‘Laetitia’, ‘Joly’, ‘Arianna’, ‘Tea’, and ‘Mila’ cultivars were distinguished from others as the richest concerning almost all flavonoids and phenolic acids, including some other parameters of bioactivity. These cultivars could be recommended to consumers as functional fruit foods.
On the development of caustics in shear flows over rigid walls

In this paper the scattered field produced by a source inside a shear layer of arbitrary profile, flowing above an infinite, rigid wall, is examined. The shear layer is topped by a uniform flow. A representation of the solution is obtained in terms of a pair of functions that satisfy a homogeneous second-order ordinary differential equation, with variable coefficients. The asymptotic form of these functions is obtained in the high-frequency limit. The representation yields, in this limit, a pair of parametric equations whose solutions describe the formation of infinite families of caustics inside the shear layer and downstream of the source. This is in agreement with previous results found by employing ray-theory techniques. Applications are given to the linear profile. The advantages of the present method and its application to other physical problems are discussed.
Viral Zoonotic Diseases of Public Health Importance and Their Effect on Male Reproduction

Zoonotic diseases occur as a result of human interactions with animals with the inadvertent transmission of pathogens from one to another. Zoonoses remain a major cause of morbidity and mortality among human populations, as they have been a source of pandemics in human history. Viral zoonoses account for a significant percentage of pathogens of zoonotic sources, posing a huge risk to men’s general health and fertility. This review identifies the existing knowledge on the effects of viral zoonotic diseases on male fertility. Evidence from reviewed articles showed that viral zoonotic diseases elicit an immune reaction that induces inflammatory mediators and impairs testicular functions such as spermatogenesis and steroidogenesis, leading to abnormal semen parameters that lead to subfertility/infertility. Although most zoonotic viruses linger in semen long after recovery, their presence in semen does not directly translate to sexual transmission. There is a need to further delineate the possible risk of the sexual transmission of these diseases. While a few of the viral zoonotic diseases discussed have been well-studied, there is a need to place attention on others so as to fully understand their effects on male reproduction and therefore take the right steps towards preserving male fertility.
ON HARMONIC BLOCH SPACES IN THE UNIT BALL OF ℂn

Abstract In this paper, our main aim is to discuss the properties of harmonic mappings in the unit ball 𝔹n. First, we characterize the harmonic Bloch spaces and the little harmonic Bloch spaces from 𝔹n to ℂ in terms of weighted Lipschitz functions. Then we prove the existence of a Landau–Bloch constant for a class of vector-valued harmonic Bloch mappings from 𝔹n to ℂn.
Shifting incidence and survival of epithelial ovarian cancer (1995‐2014): A SurvMark‐2 study

The aim of the study is to provide a comprehensive assessment of incidence and survival trends of epithelial ovarian cancer (EOC) by histological subtype across seven high income countries (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the United Kingdom). Data on invasive EOC diagnosed in women aged 15 to 99 years during 1995 to 2014 were obtained from 20 cancer registries. Age standardized incidence rates and average annual percentage change were calculated by subtype for all ages and age groups (15‐64 and 65‐99 years). Net survival (NS) was estimated by subtype, age group and 5‐year period using Pohar‐Perme estimator. Our findings showed marked increase in serous carcinoma incidence was observed between 1995 and 2014 among women aged 65 to 99 years with average annual increase ranging between 2.2% and 5.8%. We documented a marked decrease in the incidence of adenocarcinoma “not otherwise specified” with estimates ranging between 4.4% and 7.4% in women aged 15 to 64 years and between 2.0% and 3.7% among the older age group. Improved survival, combining all EOC subtypes, was observed for all ages combined over the 20‐year study period in all countries with 5‐year NS absolute percent change ranging between 5.0 in Canada and 12.6 in Denmark. Several factors such as changes in guidelines and advancement in diagnostic tools may potentially influence the observed shift in histological subtypes and temporal trends. Progress in clinical management and treatment over the past decades potentially plays a role in the observed improvements in EOC survival.
Student Presenteeism in Digital Times—A Mixed Methods Approach

In young adulthood, important foundations are laid for health later in life. Hence, more attention should be paid to the health measures concerning students. A research field that is relevant to health but hitherto somewhat neglected in the student context is the phenomenon of presenteeism. Presenteeism refers to working despite illness and is associated with negative health and work-related effects. The study attempts to bridge the research gap regarding students and examines the effects of and reasons for this behavior. The consequences of digital learning on presenteeism behavior are moreover considered. A student survey (N = 1036) and qualitative interviews (N = 11) were conducted. The results of the quantitative study show significant negative relationships between presenteeism and health status, well-being, and ability to study. An increased experience of stress and a low level of detachment as characteristics of digital learning also show significant relationships with presenteeism. The qualitative interviews highlighted the aspect of not wanting to miss anything as the most important reason for presenteeism. The results provide useful insights for developing countermeasures to be easily integrated into university life, such as establishing fixed learning partners or the use of additional digital learning material.
User and Robot Personality Interactions in Parasocial Presence and Intention to Use Social Robots

The present research explores how the relationship between a user’s personality and the perceived personality of a social robot influences the relationship of parasocial presence, para-friendship, and intention to use a social robot. Specifically, the research examines how continued use of a social robot is related to the interaction of user and perceived robot personality through the mediating role of parasocial presence. Participants interacted with a social robot in a semi-structured interaction and provided ratings of parasocial presence, robot personality, and use intention. Although parasocial presence and para-friendship aspects the interaction predicted intention to use the robot, personality similarity at the profile level did not impact this relationship.
Cyclic Variations of the Imposed Temperature Contrast in a Thermally Driven Rotating Annulus of Fluid

Abstract Rotating annulus experiments are described in which the imposed thermal forcing is varied periodically by means of cyclic variations of the cold inner-bath temperature. In the way of background the results of conventional annulus experiments, in which the imposed temperature contrast is not varied, and of hysteresis experiments, in which the imposed temperature contrast is varied slowly enough to be considered quasi-static, are reviewed. It is found that, in the region of dimensionless-parameter space in which our experiments were conducted, the flow configuration in conventional and hysteresis experiments is determinate in the following sense: once a flow is established at a given point in this region of dimensionless-parameter space, this flow will remain unless a critical value of the imposed parameters is reached for the onset of another state. The flow configuration in experiments in which the imposed temperature contrast is varied in a cyclic fashion is found to be indeterminate in the sens.
COVID-19 Risk Perception and Prevention Practices among High- and Low-Density Populations in Bangladesh: A Mixed-Methods Study

We aimed to explore coronavirus disease 2019 (COVID-19) risk perception and prevention practices among people living in high- and low-population density areas in Dhaka, Bangladesh. A total of 623 patients with confirmed COVID-19 agreed to participate in the survey. Additionally, we purposively selected 14 participants from diverse economic and occupational groups and conducted qualitative interviews for them accordingly. Approximately 70% of the respondents had low socioeconomic status. Among the 623 respondents, 146 were from low-density areas, and 477 were from high-density areas. The findings showed that study participants perceived COVID-19 as a punishment from the Almighty, especially for non-Muslims, and were not concerned about its severity. They also believed that coronavirus would not survive in hot temperatures or negatively impact Bangladeshis. This study revealed that people were reluctant to undergo COVID-19 testing. Family members hid if anyone tested positive for COVID-19 or did not adhere to institutional isolation. The findings showed that participants were not concerned about COVID-19 and believed that coronavirus would not have a devastating impact on Bangladeshis; thus, they were reluctant to follow prevention measures and undergo testing. Tailored interventions for specific targeted groups would be relevant in mitigating the prevailing misconceptions.
Analysis of top-cited articles on melanoma.

INTRODUCTION This bibliometric analysis evaluates the most influential studies in clinical research on melanoma. METHODS Based on the bibliometric theory, articles in the Thomson Reuters Web of Science database were analyzed. Full English-language articles were searched for using the terms melanoma, superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma, and acral lentiginous melanoma. The 100 most-cited articles were analyzed by topic, author, journal of publication, year of publication, institution, and country of origin. RESULTS The search returned 243,109 articles, with the majority from the past 3 decades: 1991-2000 (n = 29), 2001-2010 (n = 28), and 2011-2020 (n = 30). The top 100 cited articles had mean and median citations of 2,159 and 1,793, respectively. An article on the use of ipilimumab in metastatic melanoma, by Hodi et al., was most cited (8,150). The New England Journal of Medicine had the most citations (58,489), and Nature published the most articles (n = 21). The United States published the most articles (n = 81), led by the National Cancer Institute (n = 16). The majority of articles explored management (n = 68), prognosis (n = 57), and immunotherapy (n = 27). CONCLUSIONS This analysis serves as a guide for future research and highlights key areas of research, particularly in genetics and immunotherapy, that have influenced current knowledge of melanoma.
Competency in ECG Interpretation and Arrhythmias Management among Critical Care Nurses in Saudi Arabia: A Cross Sectional Study

Background: Electrographic interpretation skills are important for healthcare practitioners caring for patients in need of cardiac assessment. Competency in ECG interpretation skills is critical to determine any abnormalities and initiate the appropriate care required. The purpose of the study was to determine the level of competence in electrocardiographic interpretation and knowledge in arrhythmia management of nurses in critical care settings. Methods: A descriptive cross-sectional design was used. A convenience sample of 255 critical care nurses from 4 hospitals in the Al-Madinah Region in Saudi Arabia was used. A questionnaire was designed containing a participant’s characteristics and 10 questions with electrocardiographic strips. A pilot test was carried out to evaluate the validity and reliability of the questionnaire. Descriptive and bivariate analyses were conducted using an independent t-test, one-way ANOVA, or bi-variate correlation tests, as appropriate. A statistical significance of p < 0.05 was assumed. Results: Females comprised 87.5% of the sample, and the mean age of the sample was 32.1 (SD = 5.37) years. The majority of the participants (94.9%) had taken electrocardiographic interpretation training courses. The mean total score of correct answers of all 10 ECG strips was 6.45 (±2.54) for ECG interpretation and 4.76 (±2.52) for arrhythmia management. No significant differences were observed between ECG competency level and nursing experience or previous training. Nurses working in the ICU and CCU scored significantly higher than those working in ED. Conclusions: The electrocardiographic knowledge in ECG interpretation and arrhythmia management of critical care nurses is low. Therefore, improving critical care nurses’ knowledge of ECGs, identification, and management of cardiac arrhythmias is essential.
Development of eplerenone nano sono-crystals using factorial design: enhanced solubility and dissolution rate via anti solvent crystallization technique

Abstract Objective The purpose of this work was to improve EP solubility by using a sono-crystalization approach to reduce particle size and hence, increase the dissolution rate. Significance Eplerenone (EP) is an antagonist of the aldosterone receptor and is used for the treatment of hypertension and chronic heart failure. EP was classed as biopharmaceutical classification (BCS) class II because of its poor solubility and high permeability, which retards dissolution rate and drug absorption, and decreases bioavailability. Methods Three-factors and two-level (23) multifactorial design have been employed to study the effect of independent variables which are drug concentration; (X1), stabilizer type (X2), and stabilizer concentration (X3) on responses; saturated solubility of EP in distilled water (Y1), saturated solubility in acidic media pH 1.2 (Y2), particle size (Y3), and polydispersity index, PDI (Y4). Also, they were characterized by Fourier transformed infrared spectroscopy (FTIR), Powder X-ray diffraction (PXRD), Differential scanning calorimetry (DSC), and yield percentage. The optimum formula was further subjected to an in-vitro release study. Results The optimized formulation showed a saturated solubility of EP as 1.29, and 1.86 (mg/ml) in distilled water and acidic media (pH 1.2) respectively. Also, the particle size of 133 nm, and PDI of 0.824 with a small percentage of the difference between the observed and predicted values. Ninety-one percent of EP was released within 10 min., and it was completely released within 45 min. with a significantly higher release rate compared to raw drug. Conclusion This work resulted in a satisfactory enhancement of solubility and dissolution rate which, is suitable for further in-vivo analysis. Graphical Abstract
Proteomic Changes in Response to Colorless nonripening Mutation during Tomato Fruit Ripening

SlSPL-CNR is a multifunctional transcription factor gene that plays important roles in regulating tomato fruit ripening. However, the molecular basis of SlSPL-CNR in the regulatory networks is not exactly clear. In the present study, the biochemical characteristics and expression levels of genes involved in ethylene biosynthesis in Colorless nonripening (Cnr) natural mutant were determined. The proteomic changes during the ripening stage were also uncovered by isobaric tags for relative and absolute quantitation (iTRAQ)–based quantitative proteomic analysis. Results indicated that both the lycopene content and soluble solid content (SSC) in Cnr fruit were lower than those in wild-type AC fruit. Meanwhile, pH, flavonoid content, and chlorophyll content were higher in Cnr fruit. Expressions of genes involved in ethylene biosynthesis were also downregulated or delayed in Cnr fruit. Furthermore, 1024 and 1234 differentially expressed proteins (DEPs) were respectively identified for the breaker and 10 days postbreaker stages. Among them, a total of 512 proteins were differentially expressed at both stages. In addition, the functions of DEPs were classified by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Results would lay the groundwork for wider explorations of the regulatory mechanism of SlSPL-CNR on tomato fruit ripening.