Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic and structural differences between heme oxygenase-1 and -2 are due to differences in their C-terminal regions

Heme oxygenase (HO) catalyzes heme degradation, a process crucial for regulating cellular levels of this vital, but cytotoxic, cofactor. Two HO isoforms, HO1 and HO2, exhibit similar catalytic mechanisms and efficiencies. They also share catalytic core structures, including the heme-binding site. Outside their catalytic cores are two regions unique to HO2: a 20-amino acid–long N-terminal extension and a C-terminal domain containing two heme regulatory motifs (HRMs) that bind heme independently of the core. Both HO isoforms contain a C-terminal hydrophobic membrane anchor; however, their sequences diverge. Here, using hydrogen–deuterium exchange MS, size-exclusion chromatography, and sedimentation velocity, we investigated how these divergent regions impact the dynamics and structure of the apo and heme-bound forms of HO1 and HO2. Our results reveal that heme binding to the catalytic cores of HO1 and HO2 causes similar dynamic and structural changes in regions (proximal, distal, and A6 helices) within and linked to the heme pocket. We observed that full-length HO2 is more dynamic than truncated forms lacking the membrane-anchoring region, despite sharing the same steady-state activity and heme-binding properties. In contrast, the membrane anchor of HO1 did not influence its dynamics. Furthermore, although residues within the HRM domain facilitated HO2 dimerization, neither the HRM region nor the N-terminal extension appeared to affect HO2 dynamics. In summary, our results highlight significant dynamic and structural differences between HO2 and HO1 and indicate that their dissimilar C-terminal regions play a major role in controlling the structural dynamics of these two proteins.
Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus

Lipid disorders have been associated with glomerulopathies, a distinct type of renal pathologies, such as nephrotic syndrome. Global analyses targeting kidney lipids in this pathophysiologic context have been extensively performed, but most often regardless of the architectural and functional complexity of the kidney. The new developments in mass spectrometry imaging technologies have opened a promising field in localized lipidomic studies focused on this organ. In this article, we revisit the main works having employed the Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) technology, and the few reports on the use of TOF-Secondary Ion Mass Spectrometry (TOF-SIMS). We also present a first analysis of mouse kidney cortex sections by cluster TOF-SIMS. The latter represents a good option for high resolution lipid imaging when frozen unfixed histological samples are available. The advantages and drawbacks of this developing field are discussed.
RECALLED PARENTAL REARING STYLE AND DIMENSIONS OF HYPNOTIC RESPONSE

Abstract So far, only a few studies have investigated how memories of parental rearing style are associated with hypnotic response, and these were either qualitative or confined to the behavioral aspect of hypnotizability. The present study aims to employ standardized, quantitative measures to investigate the associations between recalled parental rearing style and the behavioral, phenomenological, and emotional dimensions of hypnotic response. Two samples of healthy adult subjects (N = 438) completed a questionnaire on their parents’ behavior and participated in a standard group hypnosis session in which their hypnotizability score, hypnotic experiences, and archaic involvement were assessed. Memories of cold and punishing parental behavior were associated with negative experiences related to the hypnotic state and negative emotions toward the hypnotist. The authors conclude that assessing parental behavior may be important in planning hypnotherapeutic interventions.
Bone development and remodeling in metabolic disorders

There are many metabolic disorders that present with bone phenotypes. In some cases, the pathological bone symptoms are the main features of the disease whereas in others they are a secondary characteristic. In general, the generation of the bone problems in these disorders is not well understood and the therapeutic options for them are scarce. Bone development occurs in the early stages of embryonic development where the bone formation, or osteogenesis, takes place. This osteogenesis can be produced through the direct transformation of the pre‐existing mesenchymal cells into bone tissue (intramembranous ossification) or by the replacement of the cartilage by bone (endochondral ossification). In contrast, bone remodeling takes place during the bone's growth, after the bone development, and continues throughout the whole life. The remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix by the osteoblasts, which subsequently becomes mineralized. In some metabolic diseases, bone pathological features are associated with bone development problems but in others they are associated with bone remodeling. Here, we describe three examples of impaired bone development or remodeling in metabolic diseases, including work by others and the results from our research. In particular, we will focus on hereditary multiple exostosis (or osteochondromatosis), Gaucher disease, and the susceptibility to atypical femoral fracture in patients treated with bisphosphonates for several years.
Role of VDR, GC, and CYP2R1 Polymorphisms in the Development of Hepatocellular Carcinoma in Hepatitis C Virus-Infected Patients.

Aims: This study was designed to determine if vitamin D receptor (VDR), carrier globulin/binding protein (GC), and cytochrome P-450 family 2, subfamily R, polypeptide 1 (CYP2R1) gene polymorphisms are risk factors in the development of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV)-infected patients from Northeast India. Materials and Methods: A total of 351 HCV-infected patients were enrolled of which 167 were diagnosed with chronic hepatitis C (CHC), 124 with liver cirrhosis (LC), and 60 with HCC together with 102 age- and sex-matched healthy controls. VDR (BsmI, ApaI, and TaqI), GC (rs4588, rs7051), and CYP2R1 (rs10741657) gene polymorphisms were genotyped for all subjects. Statistical data were analyzed using SPSS ver. 22.0. Results: The frequency of the ApaI CC genotype, ApaI C allele, and bAt haplotype of the VDR gene was significantly higher in HCC and LC patients than controls. After adjusting for other covariates (age, gender, platelet count, AST, ALT, serum albumin, and viral load) logistic regression analysis showed that the ApaI CC genotype and bAt haplotype were independent predictors of HCC development. No significant associations was found for the GC and CYP2R1 polymorphisms examined with the occurrence of HCC. Conclusions: The presence of the VDR ApaI CC genotype and bAt haplotype appear to be important indicators in the development of HCC among HCV-infected patients. Larger studies are needed to further clarify and establish this potential causal relationship.
The Challenges of Informed Consent in High-Stakes, Randomized Oncology Trials: A Systematic Review

Importance. Oncology trials often entail high-stakes interventions where potential for morbidity and fatal side effects, and for life-prolongation or cure, intensify bioethical issues surrounding informed consent. These challenges are compounded in multistage randomized trials, which are prevalent in oncology. Objective. We sought to elucidate the major barriers to informed consent in high-stakes oncology trials in general and the best consent practices for multistage randomized trials. Evidence Review. We queried PubMed for original studies published from January 1, 1990, to April 5, 2018, that focused on readability, quality, complexity or length of consent documents, motivation and sickness level of participants, or interventions and enhancements that influence informed consent for high-stakes oncologic interventions. Exclusion criteria included articles focused on populations outside industrialized countries, minors or other vulnerable populations, physician preferences, cancer screening and prevention, or recruitment strategies. Additional articles were identified through comprehensive bibliographic review. Findings. Twenty-seven articles were retained; 19 enrolled participants and 8 examined samples of consent documents. Methodologic quality was variable. This body of literature identified certain challenges that can be readily remedied. For example, the average length of the consent forms has increased 10-fold from 1987 to 2010, and patient understanding was shown to be inversely proportional to page count; shortening forms, or providing a concise summary as mandated by the revised Common Rule, might help. However, barriers to understanding that stem from deeply ingrained and flawed sociocultural perceptions of medical research seem more difficult to surmount. Although no studies specifically addressed problems posed by multiple sequential randomizations (such as change in risk-benefit ratio due to time-varying treatment responses or organ toxicities), the findings are likely applicable and especially relevant in that context. Concrete suggestions for improvement are proposed.
Sex Crime Recidivism: Evaluation of a Sexual Offender Treatment Program

Evaluations of programs for sex offenders report mixed results, are costly and require validation. This study examines recidivism following a sexual offender treatment program in an Australian male offender population over an average at-risk period of five years and one month in the community. The group format cognitive behavioural program was offered to a subgroup of adult male prisoners. Subsequent re-offence types and rates for program completers, dropouts and controls were compared. No statistically significant recidivism reduction was observed following participation in this Sexual Offender Treatment Program, whereas recidivism appears to be related to a history of violent or sexual offences. The initial promise of sexual offender treatment programs must be further examined by individual and meta-analytic studies. Limited follow-up, missing data and fidelity of the program may have contributed to the null result. Monitoring treatment programs to ensure inclusion of proven interventions may enhance future program effectiveness.
A 51.2-GOPS scalable video recognition processor for intelligent cruise control based on a linear array of 128 four-way VLIW processing elements

This paper describes a 51.2-GOPS video recognition processor, which achieves real-time multiple processing of in-vehicle video recognition applications in software, while at the same time satisfying power efficiency requirements of an in-vehicle device. The chip integrates 128 RISC microprocessors, each operating at 100 MHz, into a single chip. Hardware configurations of the chip are enhanced for supporting efficient execution of extended C language codes of algorithms based on four basic parallel methods. The results of a benchmark test using a weather-robust lane mark and vehicle detection application show that the processor achieves a four times better performance while it consumes less than 1/20 of peak power consumption compared with a 2.4-GHz general-purpose processor.
Modular Length Control for Sentence Generation

Generating summary-sentences with preserved meaning is important for the summarization of longer documents. Length control of summary-sentences is challenging as sentences cannot simply be cut at the desired length; they must be complete and preserve input meaning. We propose a modular framework for length control of generated sentences: based on sequence-to-sequence models, powered by a two-stage training process involving a summarizer that is trained without explicit length control and a stylizer that is ﬁne-tuned on the output of the summarizer. Our solution achieves the performance of existing models for controlling generated sentence length but light in implementation and model complexity.
Seabird‐induced natural mortality of forage fish varies with fish abundance: Evidence from five ecosystems

1IPHC, CNRS, Université de Strasbourg, Strasbourg, France 2MARBEC, CNRS, IRD, IFREMER, Université de Montpellier, Sète, France 3Farallon Institute for Advanced Ecosystem Research, Petaluma, CA, USA 4US Geological Survey, Alaska Science Center, Anchorage, AK, USA 5Norwegian Institute for Nature Research, Trondheim, Norway 6Department of Aquatic Resources, Swedish University of Agricultural Sciences, Lysekil, Sweden 7IRD, UMR MARBEC (Université de Montpellier/CNRS/IRD/IFREMER), Sète, France 8University of Glasgow, Glasgow, UK 9, Kaikoura, New Zealand 10, Corning, NY, USA 11Stockholm Resilience centre, Stockholm University, Stockholm, Sweden 12Institute of Hydrobiology and Fisheries Science, University of Hamburg, Hamburg, Germany 13Namibia Nature Fundation and SEACODE, Lüderitz, Namibia 14Ministry of Fisheries and Marine Resources, Lüderitz, Namibia 15Department of Biological Sciences, University of Cape Town, Cape Town, South Africa 16Department of Environment, Forestry and Fisheries, Branch Oceans and Coasts, Cape Town, South Africa
Social support and self-rated health among caregivers of people with dementia: The mediating role of caregiving burden

The purpose of this study was to examine the associations between three indicators of social support and self-rated health among caregivers of people with dementia, and whether caregiving burden mediated such associations. Data from the Resources for Enhancing Alzheimer’s Caregiver Health II (REACH II; N = 637) was used and multivariate analyses were conducted to test the mediation effects of caregiving burden by PROCESS for v3.2. 03. The results revealed that three indicators of social support (received support, social network, and negative interactions) were all significantly associated with self-rated health. Findings also showed that caregiving burden acted as a mediator mechanism through which the associations between social network and self-rated health, negative interactions and self-rated health occurred. Results suggest that there is a need for more comprehensive caregiving assessments as well as multicomponent interventions that include improving and expanding social networks for caregivers of people with dementia. Findings also highlight the importance of minimizing interpersonal conflicts with others and providing more multicomponent programs aimed at reducing caregiving burden.
Characteristics and Significance of Healed Plaques in Patients with Acute Coronary Syndrome and Stable Angina: An In Vivo OCT and IVUS Study.

AIMS To determine the prevalence and significance of plaque with a multilayered (ML) pattern in patients with acute coronary syndrome (ACS) vs stable angina pectoris (SAP) using OCT. METHODS AND RESULTS 204 patients (144 ACS and 60 SAP) with OCT imaging of the culprit lesions before intervention were studied. ML plaques were identified by OCT as a plaque with multiple layers of distinct optical signals. ML plaque was identified in 119 out of 204 (58.3%) patients. ML plaques were more frequently observed in SAP than ACS (75% vs. 51.4%, p=0.001). Patients with prior myocardial infarction (MI) had higher incidence of ML plaque compare with those without (74.4% vs. 54.5%, p=0.024). ML plaque had a higher degree of luminal stenosis (p=0.006), longer lesion length (p=0.025), more complex lesion type (B2/C) (p<0.001) on angiogram and non-significant larger plaque burden (p=0.07) on IVUS compared with those without ML pattern. CONCLUSIONS ML plaques, indicative of prior thrombosis, were frequently identified in patients with CAD, particularly higher in SAP and those with prior MI compared with ACS. The presence of ML pattern is a marker of greater extent and severity of CAD, suggesting a pathogenic link between plaque healing and lesion progression.
Detection of tick-borne pathogens in questing Ixodes ricinus in the French Pyrenees and first identification of Rickettsia monacensis in France

Ticks are important vectors of several human and animal pathogens. In this study, we estimated the prevalence of important tick-borne infections in questing ticks from an area in Southwestern France (Hautes-Pyrénées) inhabited by Pyrenean chamois (Rupicapra pyrenaica pyrenaica) experiencing high tick burden. We examined adult and nymph ticks collected by the flag dragging method from 8 to 15 sites in the Pic de Bazès during the years 2009, 2011, 2013 and 2015. PCR assays were conducted on selected ticks for the detection of Borrelia burgdorferi s.l. , Babesia spp. , Rickettsia spp. , spotted fever group (SFG) Rickettsia and Anaplasma phagocytophilum. Randomly selected positive samples were submitted for sequence analysis. A total of 1971 questing ticks were collected including 95 males, 101 females and 1775 nymphs. All collected ticks were identified as Ixodes ricinus. Among them, 696 ticks were selected for pathogen detection and overall prevalence was 8.4% for B. burgdorferi s.l. ; 0.4% for Babesia spp. ; 6.1% for A. phagocytophilum; 17.6% for Rickettsia spp. ; and 8.1% for SFG Rickettsia. Among the sequenced pathogens, we detected in this population of ticks the presence of Babesia sp. EU1 and Rickettsia helvetica, as well as Rickettsia monacensis for the first time in France. The detection of these pathogens in the Pic de Bazès highlights the potential infection risks for visitors to this area and the Pyrenean chamois population.
Video for Knowledge Translation: Engaging Older Adults in Social and Physical Activity

RÉSUMÉ Une vaste majorité des Canadiens âgés ne pratiquent pas suffisamment d’activité physique. Le développement de stratégies originales et innovantes encourageant et appuyant les modes de vie actifs est donc urgent. La vidéo est un outil prometteur pour l’application de connaissances (AC) visant l’engagement de divers publics dans la discussion et l’adoption de comportements favorisant la santé. L’Approche systématique pour les vidéos fondées sur des données probantes (Systematic Approach to Evidence-informed Video, SAEV), qui fournit un cadre pour guider et structurer le développement de vidéos ayant pour objectif l’AC, a été utilisée pour la création et la diffusion d’un documentaire de 19 minutes, I’d Rather Stay (https://vimeo.com/80503957). Quarante-huit participants âgés de 60 ans et plus ont visionné la vidéo, participé à des groupes de discussion et rempli des questionnaires concernant cette vidéo. Les données ont été recueillies après le visionnement et lors d’un suivi organisé six mois plus tard. La vidéo a éduqué, encouragé et mobilisé les personnes âgées sur les questions liées à l’autonomie, à l’activité physique et aux liens sociaux. Nous encourageons les chercheurs à adopter des stratégies d’AC auxquelles les personnes âgées peuvent s’identifier, qui sont accessibles et par lesquelles elles peuvent s’engager à un niveau critique, autant sur le plan émotionnel qu’intellectuel, comme les vidéos basées sur des preuves scientifiques. ABSTRACT Most older Canadians do not engage in sufficient physical activity. There is an urgent need for outside-the-box strategies that encourage and sustain active lifestyles. Video is a promising knowledge translation (KT) tool to engage diverse audiences in discussion and action around health promoting behaviours. We adopted a KT framework to inform a structured process of video development we have named systematic approach to evidence-informed video (SAEV). This guided the creation and dissemination of a 19-minute documentary video: I’d Rather Stay (https://vimeo.com/80503957). Following screenings, we collected focus group and questionnaire data from 48 participants aged 60 years and older at baseline and 6-month follow-up. The video educated, encouraged, and activated older people around issues such as independence, physical activity and social connectedness. We encourage researchers to adopt KT strategies – and to use evidence-informed video – that older adults can relate to and critically engage with on an accessible, emotional, and intellectual level.
Politico-Financial Crises: New Evidence

Using a wide sample of countries during the period 1970-2004, we instrument leader exits and financial crises to assess the causal effect each has on the other. We find that leader exits due to scheduled elections and term limits raise the probability of a banking crisis in the same year by 9% and that of a twin crisis by 7.6%. These effects are highly significant statistically, robust, and confined primarily to presidential regimes. In contrast, for financial crises instrumented with determinants from early warning models, only sovereign defaults appear to induce the exit of national leaders.
Measuring the Coworker Eﬀects on Wages ∗

The fast growing literature studying the impact of co-workers on individual’s wages has recently made signiﬁcant progress by developing techniques that allowed it to move from small and idiosyncratic case studies to more generalizable studies based on large labor markets. However, I show that the empirical methodology underlying this shift delivers a large positive or negative bias in measured co-worker eﬀects in realistic settings. I combine insights from the assortative matching theory with recent computer science advances in graph embedding techniques to develop a machine learning method that allows researchers to obtain eﬃcient and unbiased estimates in those settings. The proposed method allows to non-parametrically measure the potentially heterogeneous impact of diﬀerent co-workers on individuals’s wages. I am currently using the proposed method to measure co-worker eﬀects in the matched employer-employee panel data covering the entire population of Denmark.
Cooperative Relay and Jammer Node Selection Strategies Based on Feed-Forward Neural Network

Cooperative non-orthogonal multi-access networking is a promising model for future wireless networks, due to its benefits in terms of energy efficiency, broader coverage and reducing interference. In this paper, under the presence of an eavesdropper node, we are researching the secrecy efficiency of a downlink cooperative non-orthogonal multi access (NOMA) communication system. This paper proposes a cooperative node based on deep learning feed forward neural network. The selected cooperative relay node is employed to enhance the channel capacity of the legal users, where the selected cooperative jammer is employed to degrade the capacity of the wiretapped channel. Simulations of the secrecy performance metric namely the secrecy capacity (Cs) are presented and compared with the conventional technique based on fuzzy logic node selection technique. Based on our simulations and discussions the proposed technique outperforms the existing technique in terms of the secrecy performance.
Design of Raspberry Pi Web-based Energy Monitoring System for Residential Electricity Consumption

The application of communication and information technology for monitoring household and building activities is one of the exciting topics in future smart city development research. This paper presents the design of electrical energy monitoring using the PZEM-004T energy sensor and Raspberry Pi 4 as a web server. The system designed for measuring current, voltage, power, and energy and send it to a database as the purpose for display on infographics web pages in real-time. The web pages interface has a responsive design, so the stored data in the database can access on both desktop and mobile phone for flexibility. Based on the results for various loading, it can be concluded that the design of the electrical energy monitoring device is working well with an average error of less than 2%. The user interface also shows the real-time electrical parameter on both desktop and mobile phone.