Miracle-dz/UniFAR-FTUs huggingface dataset:
Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis

Background: Silent information regulator 2 homolog 1 (SIRT1) is an evolutionarily conserved enzymes with nicotinamide adenine dinucleotide (NAD)+-dependent deacetylase activity. SIRT1 is involved in a large variety of cellular processes, such as genomic stability, energy metabolism, senescence, gene transcription, and oxidative stress. SIRT1 has long been recognized as both a tumor promoter and tumor suppressor. Its prognostic role in cancers remains controversial. Methods: A meta-analysis of 13,138 subjects in 63 articles from PubMed, EMBASE, and Cochrane Library was performed to evaluate survival and clinicopathological significance of SIRT1 expression in various cancers. Results: The pooled results of meta-analysis showed that elevated expression of SIRT1 implies a poor overall survival (OS) of cancer patients [Hazard Ratio (HR) = 1.566, 95% CI: 1.293–1.895, P < 0.0001], disease free survival (DFS) (HR = 1.631, 95% CI: 1.250–2.130, P = 0.0003), event free survival (EFS) (HR = 2.534, 95% CI: 1.602–4.009, P = 0.0001), and progress-free survival (PFS) (HR = 3.325 95% CI: 2.762–4.003, P < 0.0001). Elevated SIRT1 level was associated with tumor stage [Relative Risk (RR) = 1.299, 95% CI: 1.114–1.514, P = 0.0008], lymph node metastasis (RR = 1.172, 95% CI: 1.010–1.360, P = 0.0363), and distant metastasis (RR = 1.562, 95% CI: 1.022–2.387, P = 0.0392). Meta-regression and subgroup analysis revealed that ethnic background has influence on the role of SIRT1 expression in predicting survival and clinicopathological characteristics of cancers. Overexpression of SIRT1 predicted a worse OS and higher TNM stage and lymphatic metastasis in Asian population especially in China. Conclusion: Our data suggested that elevated expression of SIRT1 predicted a poor OS, DFS, EFS, PFS, but not for recurrence-free survival (RFS) and cancer-specific survival (CCS). SIRT1 overexpression was associated with higher tumor stage, lymph node metastasis, and distant metastasis. SIRT1-mediated molecular events and biological processes could be an underlying mechanism for metastasis and SIRT1 is a therapeutic target for inhibiting metastasis, leading to good prognosis.
Examining differences in cigarette smoking prevalence among young adults across national surveillance surveys

Accurate smoking prevalence data is critical for monitoring, surveillance, and evaluation. However, estimates of prevalence vary across surveys due to various factors. This study examines smoking prevalence estimates for 18–21 year olds across six U.S. national telephone, online and in-person surveys for the years 2013 and 2014. Estimates of ever smoking ranged from 35% to 55%. Current smoking ranged from 16% to 30%. Across the three modalities, household surveys were found to yield the highest estimates of smoking prevalence among 18 to 21 year olds while online surveys yielded the lowest estimates, and this was consistent when stratifying by gender and race/ethnicity. Assessments of the joint effect of gender, race/ethnicity, educational attainment and survey mode indicated that the relative differences in the likelihood of smoking were consistent across modes for gender and education groups. However, the relative likelihood of smoking among minority groups compared with non-Hispanic Whites varied across modes. Gender and racial/ethnic distributions for most surveys significantly differed from the U.S. Census. Over and underrepresentation of certain demographic subpopulations, variations in survey question wording, and social desirability effects may explain modality differences in smoking estimates observed in this study. Further research is needed to evaluate the effect of survey mode on variation in smoking prevalence estimates across national surveys, particularly for young adult populations.
Prevalence of Erosive Tooth Wear in Chilean Adults, 2016. A cross-sectional study.

OBJECTIVES To determine the prevalence, severity and distribution of erosive tooth wear lesions in adult patients at the Universidad de los Andes Health Center in the San Bernardo Metropolitan Region, Chile, during a period of 4 months in 2016. METHODS A cross-sectional study was conducted. A consecutive sample of patients from 18 to 46 years old who were receiving care at the Universidad de los Andes Health Center during a period from September 2016 to January 2017 was analysed. Basic erosive wear examinations (BEWE) were performed by two calibrated examiners. RESULTS A total of 535 adults were included in this study. An erosive tooth wear prevalence of 97.9% was found in which at least one surface had a BEWE score of 2 or 3 as the highest score (98.56% for females and 95.8% for males). In the sample, 75.70% and 74.77% of individuals had at least one surface with a BEWE score of 3 at the second and fifth sextant, respectively. The median of cumulative BEWE scores was 12. The median by individual of the affected percentage of tooth surfaces with BEWE scores 2 or 3 was 19.70%. CONCLUSIONS We found a high prevalence of erosive tooth wear, mainly in the anterior group of teeth. No differences were found between the sexes, but a positive correlation with age was found. The percentage of surfaces affected was low or moderate.
Boron Doped Graphene Quantum Structure and MoS2 Nanohybrid as Anode Materials for Highly Reversible Lithium Storage

Herein, the boron-doped graphene quantum structure (BGQS), which contains both the advantages of 0-D graphene quantum dot and 2-D reduced graphene oxide, has been fabricated by top-down hydrothermal method and then mixed with molybdenum sulfide (MoS2) to serve as an active electrode material for the enhanced electrochemical performance of lithium ion battery. Results show that 30 wt% of BGQS/MoS2 nanohybrid delivers the superior electrochemical performance in comparison with other BGQS/MoS2 and bare components. A highly reversible capacity of 3,055 mAh g−1 at a current density of 50 mA g−1 is achieved for the initial discharge and a high reversible capacity of 1,041 mAh g−1 is obtained at 100 mA g−1 after 50 cycles. The improved electrochemical performance in BGQS/MoS2 nanohybrid is attributed to the well exfoliated MoS2 structures and the presence of BGQS, which can provide the vitally nano-dimensional contact for the enhanced electrochemical performance. Results obtained in this study clearly demonstrate that BGQS/MoS2 is a promising material for lithium ion battery and can open a pathway to fabricate novel 2-D nanosheeted nanocomposites for highly reversible Li storage application.
Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice

CENP-F is a large, microtubule-binding protein that regulates multiple cellular processes including chromosome segregation and mitochondrial trafficking at cytokinesis. This multiplicity of function is mediated through the binding of various partners, like Bub1 at the kinetochore and Miro at mito-chondria. Due to the multifunctionality of CENP-F, the cellular phenotypes observed upon its depletion are difficult to interpret and there is a need to genetically separate its different functions by preventing binding to selected partners. Here we engineer a CENP-F point-mutant that is deficient in Miro binding and thus is unable to localize to mitochondria, but retains other localizations. We introduced this mutation in cultured human cells using CRISPR/Cas9 and show it causes a defect in mitochondrial spreading similar to that observed upon Miro depletion. We further create a mouse model carrying this CENP-F variant, as well as truncated CENP-F mutants lacking the farnesylated C-terminus of the protein. Importantly, one of these truncations leads to ∼80% downregulation of CENP-F expression. We observe that, despite the phenotypes apparent in cultured cells, mutant mice develop normally. Taken together, these mice will serve as important models to study CENP-F biology at organismal level. In addition, because truncations of CENP-F in humans cause a lethal disease termed Strømme syndrome and because CENP-F is involved in cancer development, they might also be relevant disease models.
Ecology and species distribution pattern of Soldanella sect. Soldanella (Primulaceae) within vegetation types in the Carpathians and the adjacent mountains

Molecular plant taxonomy methods have helped to introduce new findings to the original concepts of plant evolution in comparison to traditional classification based on morphological, karyological, and ecological characters. The objective of our study was to determine if a new taxonomic concept developed for the Soldanella genus would also change the traditional knowledge of coenological relations within plant communities and distribution patterns of habitats. Taxa in the genus Soldanella sect. Soldanella from the Carpathian Mts and the adjacent region in the North-Eastern Alps and Bohemian Massif were selected as model representatives. This territory includes the largest concentration of study taxa, namely S. carpatica, S. hungarica, S. major, S. marmarossiensis agg. , S. montana, S. oreodoxa, and potentially also some others. However, the ecological characteristics published to date are in conflict with our field observations. Two datasets were combined for the purpose of our study, one of which was based on older and published phytocoenological relevés that are now widely available through the European Vegetation Archive (EVA), and the other, which is based on our own data, sampled throughout the distribution area, which specifically targeted the type localities as well as peripheral localities. Analysis of phytocoenological relevés significantly extended the older knowledge about the habitat preferences of the studied species. Similarly, due to our detailed population sampling, a view of the geographical distribution and expansion of snowbell distribution boundaries has been added, especially for the Eastern and Southern Carpathian taxa. In revising the older knowledge, the altitudinal range of the selected species must be revised as well. In the majority of cases, our findings broadened the existing knowledge on altitudinal divergence, ecological behaviour and the phytogeographical distribution of the study species. Snowbells considered as typical montane elements in forest habitats were also found at much higher alpine altitudes, e.g. S. carpatica, S. hungarica, S. major, and S. marmarossiensis agg. , and vice versa, with taxa considered to be exclusively inhabiting the alpine belt growing in contact forest habitats as well. The spectrum of the studied habitats and plant units show wide ecological valence in the majority of Soldanella species; however, some particular preferences for different substrate types, altitudinal belts, or habitat types were indicated.
The Impact of Completing Medication Reconciliation and Depression Treatment History in an Outpatient Depression Clinic.

Objectives To enhance depression care by improving medication information available prior to initial patient consultations. Experimental Design and Sample Single-center, with intervention delivered to all new patient referrals at a tertiary care depression clinic. Trained pharmacy students utilizing a standard script prior to the first consultation visit conducted a medication review and depression treatment telephone assessment. Results From 225 individuals contacted once by phone in the week prior to scheduled initial consultation, 141 (62.7%) were reached and 113 (50.2%) completed the full phone assessment. An average of 4-5 medication discrepancies were identified per respondent, of which one-third were considered potentially clinically significant and more than 96% of patients having at least one reported discrepancy. Individuals who completed the call were also more likely to attend the initial consultation. In the medical record, 55 of the 106 (51.9%) pharmacy notes were incorporated in the clinical assessment note. On survey, clinicians reported that access to the pharmacy note saved clinician time, with all prescribing clinicians indicating the pharmacy note significantly influenced subsequent medication recommendations. Conclusions Telephone assessments conducted by pharmacy students prior to an initial depression clinic consultation was associated with higher consultation attendance, identified a large number of medication discrepancies, were successfully reviewed and received by clinicians, potentially saved clinician time, and influenced subsequent medication prescribing.
Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy

Resveratrol (3,5,4′-trihydroxystilbene, RSV) is a natural potential anti-aging polyphenolic compound frequently used as a nutritional supplement against several diseases. However, the underlying mechanisms by which resveratrol regulates postovulatory aging of oocytes are still insufficiently known. In this study, we found that resveratrol could delay postovulatory aging and improve developmental competence of oocytes through activating selective mitophagy in the mouse. Resveratrol could maintain spindle morphology but it disturbed cortical granule (CG) distribution during oocyte aging. This might be due to upregulated mitophagy, since blocking mitophagy by cyclosporin A (CsA) treatment affected oocyte quality by damaging mitochondrial function and it decreased embryonic development. In addition, we also observed an involvement of FoxO3a in regulating mitophagy in aging oocytes following resveratrol treatment. Taken together, our results provide evidence that mitophagy induced by resveratrol is a potential mechanism to protect against postovulatory oocyte aging.
Salp Swarm Algorithm for Node Localization in Wireless Sensor Networks

Nodes localization in a wireless sensor network (WSN) aims for calculating the coordinates of unknown nodes with the assist of known nodes. The performance of a WSN can be greatly affected by the localization accuracy. In this paper, a node localization scheme is proposed based on a recent bioinspired algorithm called Salp Swarm Algorithm (SSA). The proposed algorithm is compared to well-known optimization algorithms, namely, particle swarm optimization (PSO), Butterfly optimization algorithm (BOA), firefly algorithm (FA), and grey wolf optimizer (GWO) under different WSN deployments. The simulation results show that the proposed localization algorithm is better than the other algorithms in terms of mean localization error, computing time, and the number of localized nodes.
A polyvalent coral snake antivenom with broad neutralization capacity

Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, produce small amounts of venom, and the antivenoms produced have shown limited cross neutralization. Here we present data of cross neutralization among monovalent antivenoms raised against M. dumerilii, M. isozonus, M. mipartitus and M. surinamensis and the development of a new polyvalent coral snake antivenom, resulting from the mix of monovalent antivenoms. Our results, show that this coral snake antivenom has high neutralizing potency and wide taxonomic coverage, constituting a possible alternative for a long sought Pan-American coral snake antivenom.
Effects of blood flow restriction exercise on hemostasis: a systematic review of randomized and non-randomized trials

Background Blood flow restriction (BFR) exercise has shown to induce a positive influence on bone metabolism and attenuate muscle strength loss and atrophy in subjects suffering from musculoskeletal weakness. Despite the known benefits of BFR exercise, it remains unclear whether or not the pressurization of blood vessels damages the endothelial cells or increases risk for formation of thrombi. Thus, the effects of BFR exercise on coagulation, fibrinolysis, or hemostasis, remains speculative. Objective The aim of the present study was to perform a systematic review of the short and long- term effects of BFR exercise on blood hemostasis in healthy individuals and patients with known disease (ie, hypertension, diabetes, obesity, and ischemic heart disease). Data Sources A systematic review of English and non-English articles was conducted across PubMed, Science Direct, and Google Scholar databases, including reference lists of relevant papers. Study quality assessment was evaluated using the modified version of Downs and Black checklist. Search results were limited to exercise training studies investigating the effects of BFR exercise on blood hemostasis in healthy individuals and patients with disease. Level of evidence was determined according to the criteria described by Oxford Center for Evidence-Based Medicine. Study selection Only randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs) that examined the effects of exercise with BFR exercise vs exercises without BFR on blood hemostasis in healthy individuals and patients were included. Data extraction Nine studies were eligible (RCT =4; NRCT =5). Results The average score on the Downs and Black checklist was 11.22. All studies were classified as having poor methodological quality wherein the level of evidence provided in all reviewed studies was level IIb only (ie, poor quality RCTs). Conclusion Considering the limitations in the available evidence, firm recommendations cannot be provided.
Transactional associations of maternal depressive symptoms with child externalizing behaviors are small after age 3

Abstract A large and growing body of research suggests that maternal depressive symptoms and child externalizing behaviors are strongly associated. Theoretical arguments supported by these findings led to the question of whether maternal depressive symptoms are transactionally associated with child externalizing behaviors. Using 5-year nationally representative longitudinal data from Turkey (N = 1,052), we estimated a transactional bivariate autoregressive latent trajectory model addressing this question. This model disaggregated the association of the two processes into two components: (a) the association of the interindividual differences in the trajectories; and (b) the intradyad association of the changes in maternal depressive symptoms with the changes in child externalizing behaviors. Although maternal depressive symptoms were robustly associated with child externalizing behaviors at age 3, the transactional associations of the two processes were small prior to age 5 and absent at ages 5 to 7. Furthermore, maternal harsh parenting did not have a mediating role in the limited transactional association of maternal depressive symptoms with child externalizing behaviors.
Reduction of Artefacts in JPEG-XR Compressed Images

The JPEG-XR encoding process utilizes two types of transform operations: Photo Overlap Transform (POT) and Photo Core Transform (PCT). Using the Device Porting Kit (DPK) provided by Microsoft, we performed encoding and decoding processes on JPEG XR images. It was discovered that when the quantization parameter is >1-lossy compression conditions, the resulting image displays chequerboard block artefacts, border artefacts and corner artefacts. These artefacts are due to the nonlinearity of transforms used by JPEG-XR. Typically, it is not so visible; however, it can cause problems while copying and scanning applications, as it shows nonlinear transforms when the source and the target of the image have different configurations. Hence, it is important for document image processing pipelines to take such artefacts into account. Additionally, these artefacts are most problematic for high-quality settings and appear more visible at high compression ratios. In this paper, we analyse the cause of the above artefacts. It was found that the main problem lies in the step of POT and quantization. To solve this problem, the use of a “uniform matrix” is proposed. After POT (encoding) and before inverse POT (decoding), an extra step is added to multiply this uniform matrix. Results suggest that it is an easy and effective way to decrease chequerboard, border and corner artefacts, thereby improving the image quality of lossy encoding JPEG XR than the original DPK program with no increased calculation complexity or file size.
Chronic chemotherapy with paclitaxel nanoparticles induced apoptosis in lung cancer in vitro and in vivo

Aim Paclitaxel (PTX) is an effective antitumor drug. Previous research demonstrated that paclitaxel nanoparticles (PTX-NPs) exhibited the greatest antitumor effect at 15 hours after light onset (15 HALO), but the mechanism in chronic chemotherapy is still unknown. In our study, we investigated whether PTX-NPs regulated Period2 (Per2) during chronic chemotherapy to induce apoptosis in vivo and in vitro. Methods To improve the antitumor effect and reduce organ damage induced by PTX treatment, PTX-NPs were prepared using a film dispersion method. Then, A549 cells were treated with PTX-NPs at 0, 5, 10, 15, and 20 HALO. An annexin/PI V-FITC apoptosis kit was measured for apoptosis, and PI was analyzed for cell cycle. The relative mechanism was detected by RT-PCR and Western blotting. Tumor volume and weight were measured to evaluate the antitumor effect of the PTX-NPs, and H&E staining was performed to assess organ damage. Results Cell cycle analysis demonstrated that PTX-NPs blocked cell cycle in G2 phase and that the ratio of cell death was significantly increased in A549 cells, while the ratios of cells in G2 phase and of apoptotic cells were highest at 15 HALO. Evaluation of in vivo antitumor activity revealed that PTX-NPs inhibited tumor growth and decreased tumor weight at 15 HALO. RT-PCR and Western blotting demonstrated that PTX-NPs upregulated Per2 mRNA and protein expression, and the highest Per2 expression was observed at 15 HALO in vivo and in vitro. Meanwhile, Bax mRNA and protein expression was upregulated, while Bcl-2 mRNA and protein expression was downregulated after PTX-NPs treatment in vivo. Moreover, H&E staining revealed that PTX-NPs reduced liver damage at 15 HALO. Conclusion PTX-NPs exhibited the most effective antitumor activity and reduced liver damage at 15 HALO through upregulation of Per2 expression to induce apoptosis in vivo and in vitro.
Oral Health Knowledge and Related Factors among Pregnant Women Attending to a Primary Care Center in Spain

Our aim was to assess the knowledge of pregnant women in terms of oral health and prevention, correlating it with socio-sanitary and educational factors, as well as self-care and oral health state referred. A total of 139 women from a Health Department in Comunidad Valenciana (Valencia, Spain) participated in the study. They underwent an auto-administered survey which included socio-economic and educational factors, self-care in terms of oral hygiene, referred oral health state, and general knowledge on prevention and oral health. Chi-squared test (χ2 test) and ANOVA (p < 0.05) were performed for the analysis. Variables significantly associated with general knowledge were included in a logistic regression analysis. Variables which explained general knowledge in terms of oral health were Spanish nationality (Exp B = 3.59 p = 0.017), secondary/bachelor or equivalent level of education (Exp B = 0.23 p = 0.010), medium or high level of self-care (Exp B = 0.146 p = 0.024 and Exp B = 0.208 p = 0.046, respectively), and medium or high knowledge on prevention (Exp B = 0.092 p = 0.003 and Exp B = 0.280 p = 0.017, respectively). Level of education, nationality, self-care, and knowledge on prevention and oral health were the factors that determined a greater level of general knowledge on oral health from the pregnant women.