Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Sex, Training, and Maturity Status on the Cardiopulmonary and Muscle Deoxygenation Responses during Incremental Ramp Exercise

Whilst participation in regular exercise and sport has generally increased over recent decades globally, fundamental questions remain regarding the influence of growth, maturation, and sex on the magnitude of training response throughout adolescence. Trained (108 participants, 43 girls; age: 14.3 ± 1.8 years) and untrained (108 participants, 43 girls; age: 14.7 ± 1.7 years) adolescents completed an incremental ramp test to exhaustion during which breath by gas exchange, beat-by-beat heart rate (HR), stroke volume (SV) and cardiac output (Q·) and muscle deoxygenation were assessed. Device-based physical activity was also assessed over seven consecutive days. Boys, irrespective of training status, had a significantly higher absolute (2.65 ± 0.70 L min−1 vs. 2.01 ± 0.45 L min−1, p < 0.01) and allometrically scaled (183.8 ± 31.4 mL·kg−b min−1 vs. 146.5 ± 28.5 mL·kg−b min−1, p < 0.01) peak oxygen uptake (V·O2) than girls. There were no sex differences in peak HR, SV or Q· but boys had a higher muscle deoxygenation plateau when expressed against absolute work rate and V·O2 (p < 0.05). Muscle deoxygenation appears to be more important in determining the sex differences in peak V·O2 in youth. Future research should examine the effects of sex on the response to different training methodologies in youth.
DP-Means: An Efficient Bayesian Nonparametric Model for Speaker Diarization

Recently, Bayesian probabilistic model based clustering gets superior performance in speaker diarization, however, it is much more complicated than widely used efﬁcient clustering algorithms, which is not convenient for some real-life scenarios. In this paper, we propose a covariance-asymptotic variant to Dirichlet process mixture models (DPMM), named Dirichlet process means (DP-means) clustering for speaker diarization. Similar to Bayesian nonparametric models (e.g. DPMM), DP-means can constantly generate new clusters during clustering, which is suitable to the speaker diarization problem where the number of speakers is determined on-the-ﬂy. Different from Bayesian nonparametric models, DP-means is a hard clustering that does not need to optimize the variance of mixtures, which is efﬁcient for real-world problems. We further exploited an initialization method to obtain the prior cluster centroids for DP-means. Experimental results on the CALLHOME, AMI and DIHARD III corpora show that the proposed method is more ef-ﬁcient than the state-of-the-art speaker clustering methods with slight performance degradation.
mutation outcome and mechanisms of subsequent non-responsiveness associated acute myeloid leukemia : favorable initial + Sorafenib treatment of FLT 3-ITD

Prepublished online February 24, 2012; Choi, Si Lok, Alice MS Cheung, Connie Eaves, Yok Lam Kwong and Anskar YH Leung Cheuk Him Man, Tsz Kan Fung, Christa Ho, Heron HC Han, Howard CH Chow, Alvin CH Ma, William WL with a D835 mutation outcome and mechanisms of subsequent non-responsiveness associated acute myeloid leukemia: favorable initial + Sorafenib treatment of FLT3-ITD http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary. org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
Comparison of Gut Microbiota Diversity Between Captive and Wild Tokay Gecko (Gekko gecko)

Captive animals and wild animals may exhibit different characteristics due to the heterogeneity of their living environments. The gut microbiota play an important role in the digestion and absorption, energy metabolism, immune regulation, and physiological health of the host. However, information about the gut microbiota of captive and wild Gekko gecko is currently limited. To determine the difference in gut microbiota community composition, diversity, and structure between captive and wild geckos, we used the Illumina miseq platform to conduct high-throughput sequencing and bioinformatics analysis of the v3–v4 hypervariable region of 16S rRNA in 54 gecko samples. Our results showed that Proteobacteria, Firmicutes, Bacteroidetes, and Actinobacteria were the dominant gut microbiota phyla of the gecko. The dominant genera comprised mainly Pseudomonas, Burkholderia-caballeronia-paraburkholderia, Ralstonia, Romboutsia, and Bacteroides. Captive geckos had significantly higher alpha diversity and potential pathogenic bacteria than wild populations. Moreover, significant differences in beta diversity of gut microbiota were observed between two populations. Functional prediction analysis showed that the relative abundance of functional pathways of wild geckos was more higher in metabolism, genetic information processing and organismal system function than those in captive geckos. Total length significantly affected gut microbial community (R2 = 0.4527, p = 0.001) and explained 10.45% of the total variation for gut microbial community variance between two groups. These results may be related to differences in diet and living environment between two populations, suggesting that the management of captive populations should mimic wild environments to the greatest extent possible to reduce the impact on their gut microbiota.
XPS Study in BiFeO3 Surface Modified by Argon Etching

This paper reports an XPS surface study of pure phase BiFeO3 thin film produced and later etched by pure argon ions. Analysis of high-resolution spectra from Fe 2p, Bi 4f and 5d, O 1s, and the valence band, exhibited mainly Fe3+ and Bi3+ components, but also reveal Fe2+. High-energy argon etching induces the growth of Fe(0) and Bi(0) and an increment of Fe2+, as expected. The BiFeO3 semiconductor character is preserved despite the oxygen loss, an interesting aspect for the study of the photovoltaic effect through oxygen vacancies in some ceramic films. The metal-oxygen bonds in O 1s spectra are related only to one binding energy contrary to the split from bismuth and iron reported in other works. All these data evidence that the low-pressure argon atmosphere is proved to be efficient to produce pure phase BiFeO3, even after argon etching.
DIA-Based Proteomic Analysis of Plasma Protein Profiles in Patients with Severe Acute Pancreatitis

Acute pancreatitis (AP) is a pancreatic inflammatory disease that varies greatly in course and severity. To further the understanding of the pathology of AP, we carried out data-independent acquisition-based proteomic analyses using proteins extracted from the plasma of patients with severe acute pancreatitis (SAP) (experimental group) and healthy volunteers (control group). Compared to the control group, there were 35 differentially expressed proteins (DEPs) in the plasma of patients with SAP. Of those, the expression levels for 6 proteins were significantly increased, and 29 proteins were significantly decreased. Moreover, six candidate biomarkers—VWF, ORM2, CD5L, CAT, IGLV3-10, and LTF—were matched as candidate biomarkers of the disease severity of AP. The area under the receiver operating characteristic of 0.903 (95% CI: 0.839, 0.967) indicated that this combination of these six candidate biomarkers had a good prediction accuracy for predicting the severity of AP. Our study provides specific DEPs that may be useful in the diagnosis and prognosis of SAP, which suggests new theoretical bases for the occurrence and development of SAP and offers potential novel treatment strategies for SAP.
Impact of surface drag of islands in the maritime continent on the atmospheric general circulation

In most general circulation models, the "maritime continent" is poorly resolved because there are many islands too small to be represented in the model. We investigate a possible effect of these small islands on the atmospheric general circulation by introducing surface drag over islands in model's ocean grid points. It is shown that the increased drag coefficient in the maritime continent is very effective in increasing the precipitation there by inducing stronger moisture flux convergence. Walker-type circulation anomaly is distinct over the entire equatorial Pacific along with the westerly anomaly in the lower troposphere over the Indian Ocean. There are also large impacts on both the Asian and the Australian monsoon not only for their strength but also for the onset/duration. These results imply the need of carefully handling surface conditions around the maritime continent where moisture flux convergence/heating feedback is strong, by considering the surface heterogeneity.
Strong Versions of Normality

A system for energizing lights in response to sound intensity includes a microphone feeding a detector amplifier stage which generates a signal representative of sound intensity. The output of the amplifier stage controls the switching of a phase-controlled power switch connected across one of two lamp filaments connected in series. As the intensity of one lamp increases with sound intensity, the intensity of the other decreases. Automatic gain control circuitry adjusts the gain of the amplifier stages such that the lighting effect is substantially the same response for sound changes, and it is independent of ambient sound level.
A pilot prospective prevalence study of chronic rhinosinusitis associated with inflammatory bowel disease

Abstract Background Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract. Extra‐intestinal manifestations such as pulmonary diseases have been reported. Chronic rhinosinusitis (CRS), an inflammatory condition of the sinonasal mucosa, has been associated with several lung diseases. Given the relationship between lung and intestinal pathologies, and lung and sinus pathologies, we aimed to determine the prevalence of IBD among CRS patients. Methods Pilot prevalence study. Ninety‐two CRS patients were screened for IBD symptoms from October 2018 to January 2020. Patient‐reported disease symptoms and overall quality of life were evaluated using the Sino‐Nasal Outcome Test 22 (SNOT‐22), Short Inflammatory Bowel Disease Questionnaire (SIBDQ), and EuroQol 5 Dimension 5 Level (EQ‐5D‐5L) questionnaires. The Modified Lund–Kennedy (MLK) endoscopic and Lund–Mackay (LM) grading systems were used to confirm CRS diagnoses. Individuals who reported subjective symptoms of IBD were referred to a gastroenterologist clinic for further diagnostics. Results Twenty of the 92 (20.2%, 95% CI: 12.6%–29.8%) CRS patients reported symptoms of IBD and four individuals (4.26%, 95% CI: 1.17%–10.50%) were subsequently diagnosed with IBD. Compared to patients without IBD symptoms (n = 72), those with symptoms (n = 20) reported significantly worse SNOT‐22 (P = 0.002), SIBDQ (P < 0.05), and EQ‐5D‐3L (P = 0.0063) scores. However, these patients did not exhibit significantly different MLK (P = 0.81) or LM (P = 0.04) scores. Conclusion The prevalence of IBD may be elevated among individuals with CRS relative to the general Canadian population. This pilot study suggests that CRS with IBD is associated with lower quality of life. Further cross‐sectional studies with larger sample sizes are required.
The impact of public education spending on economic growth in Central and Eastern Europe. An ARDL approach with structural break

The former communist states experienced a period of turbulence in the transition to the market economy and then the accession to the EU, turbulences that also influenced the education sector. This article aims to analyze the impact of public spending on education on economic growth in 11 former communist Eastern European states, current EU members. The methodology used is ARDL with structural break. The results are consistent with those previously obtained The public education expenditure-economic growth relationship is mixed on long term; for five countries, there is no such thing; for six countries, there is one on a long term. On a short term, also, mixed results manifest for four countries are positive, and for two negative.
Assessment of Saudi Physicians and Physical Therapists' Adherence to the Updated Clinical Practice Guideline for Benign Paroxysmal Positional Vertigo: A Cross-Sectional Study

Abstract Introduction Variations in clinical practice regarding the management of benign paroxysmal positional vertigo (BPPV) among clinicians have been noted in previous studies. Such variations might be related to the different adherence to clinical practice guidelines. Objective To evaluate clinicians' adherence to BPPV guidelines and investigate the variations in the adherence between different specialties and qualifications. Methods This is a cross-sectional study with a vignettes-based survey conducted between June and August, 2020. We included clinicians engaged in managing BPPV that had at least one year of clinical experience. We excluded students, and clinicians who were not involved in the management of individuals with BPPV. Participants were asked to make their management choices based on four hypothetical patient vignettes. The sample ranged from 77 participants for the first vignette to 45 participants for the last vignette. Results We included 77 clinicians in the study, with the majority being Otolaryngologists (31.2%). The respondents' mean adherence to the guideline was of 63.3%. Result showed that Otolaryngologists' adherence was higher than that of clinicians from different specialties ( p = 0.006, d = 0.72). Furthermore, clinicians with a postgraduate degree were more likely to adhere than those with a bachelor's degree only ( p = 0.014, d = 0.58) and participants who were aware of the guideline were more likely to adhere to it ( p < 0.001, d = 1.05). Lastly, regression analysis exhibited that adherence was affected by postgraduate degree and guideline awareness. Conclusion Otolaryngologists were more likely to adhere to the guideline than other specialties. Among all specialties, higher adherence was associated with guideline awareness and postgraduate degrees.
Fundamental movement skills in preschoolers before and during the COVID-19 pandemic in Japan: a serial cross-sectional study

Background Physical inactivity during the coronavirus disease 2019 (COVID-19) pandemic may have hindered the development of fundamental movement skills in preschoolers. This serial cross-sectional study compared fundamental movement skills by age group before and during the COVID-19 pandemic (2019–2020), among Japanese preschoolers aged 3–5 years. Methods Of the 22 preschools within Unnan City, Shimane Prefecture, Japan, 21 (95.5%) and 17 (77.3%) participated in the 2019 and 2020 surveys, respectively. We analyzed 608 and 517 preschoolers in both surveys. Fundamental movement skills were objectively assessed with a 25 m run, standing long jump, and softball throw, based on the Japanese physical activity guidelines for preschoolers. Mann–Whitney U tests were used to compare the fundamental movement skills data between periods. Results For the 25 m run, participants aged 5 years were faster before than during the pandemic (p = 0.018), while participants aged 3 and 4 years showed no significant differences. Participants aged 3–5 years showed no significant differences before and during the pandemic for the standing long jump (p ≥ 0.072). For the softball throw, all grades scored higher before than during the pandemic (p < 0.001). Conclusions These findings suggest that the COVID-19 pandemic impeded the development of fundamental motor skills, especially for object control skills. This highlights the need for interventions aimed at developing fundamental motor skills in preschoolers during and after the pandemic. Supplementary information The online version contains supplementary material available at https://doi.org/10.1265/ehpm.22-00049.
Tailoring Natural-Based Oleogels Combining Ethylcellulose and Virgin Coconut Oil

Oleogels are becoming an attractive research field, since they have recently been shown to be feasible for the food and pharmaceutical sectors and provided some insights into the biomedical area. In this work, edible oleogels were tailored through the combination of ethylcellulose (EC), a gelling agent, with virgin coconut oil (VCO), vegetable oil derived from coconut. The influence of the different EC and VCO ratios on the structural, physical, and thermal properties of the oleogels was studied. All EC/VCO-based oleogels presented a stable network with a viscoelastic nature, adequate structural stability, modulable stiffness, high oil-binding capability, antioxidant activity, and good thermal stability, evidencing the EC and VCO’s good compatibility.
Using e-learning methods for physiotherapy students learning – a systematic review and meta-analysis of the impact on knowledge, skills, satisfaction and attitudes

Abstract Aim To assess the effectiveness of e-learning methods in comparison with traditional learning on physiotherapy students’ knowledge, skills and satisfaction/attitude. Methods Seven databases including PubMed, Web of Science, Embase, Scopus, ProQuest, Ovid SP and Cochrane were searched until October 2021. Randomised controlled trials (RCTs) that compared e-learning with traditional learning or another form of digital education among physiotherapy students and assessed knowledge, skills and satisfaction/attitude were included. Cochrane effective practice and organisation of care tool was used to assess risk of bias. Results Nineteen RCTs were included. The results suggested that blended learning approach is better than traditional methods for improving skills and satisfaction/attitude in physiotherapy students, with moderate to low level of evidence. There was no difference between blended learning and traditional learning for knowledge acquisition. Pure e-learning revealed an equal result with traditional learning in all measured outcomes. Due to limited number of studies that compared one e-learning method with another form of digital education, the findings were inconclusive. Conclusion e-Learning methods made changes in knowledge, skills, satisfaction/attitude. Based on moderate to low evidence, blended learning method may be more effective than traditional learning in terms of skill acquisition and satisfaction/attitude.
Using Interactive Online Pedagogical Approaches to Promote Student Engagement

The COVID-19 outbreak in late 2019 required a complete shift to online learning across all educational institutions, including universities. The rapid transition to online learning globally meant that many educators were suddenly tasked with adapting their classroom-based pedagogy to the online space. While this was undoubtedly challenging for teachers and students, it also opened up possibilities for reimagining the delivery of content, along with creating increased access for students who had barriers for studying remotely before the impact of COVID-19. The study discussed in this paper examines the experiences of students studying at a regional Australian university that already offered online courses, and whose instructors were already using a diverse range of online delivery tools. Specifically, the study sought to investigate how instructors used interactive strategies to promote student engagement, and how the interaction between learner and content influences student engagement. With research showing that online students typically have higher attrition rates than their on-campus counterparts, engagement has been identified as an important factor in online learning. Online interaction in particular is considered to be instrumental in influencing student engagement and positively impacting student satisfaction, persistence, and academic performance. Data collected from interviews conducted with two different cohorts of students, studying two different courses (mathematics education and Chinese language) at the same university, demonstrated ways instructors utilised interactive online pedagogies to engage students with potentially challenging course content. The study has implications for online educators who are looking for ways to adapt their on-campus courses to online delivery, with a focus on engaging and maintaining online students’ interest and ongoing participation in their courses.
Development of a Patient Decision Aid to Support Shared Decision Making for Patients with Recurrent High-Grade Glioma

When high-grade gliomas recur, patients, their families, and clinicians face difficult medical decisions. There is no curable treatment, and the treatment options all come with a risk of complications and adverse effects. The patients are often cognitively affected, and they need tailored decision support. The objective of this study was to develop a patient decision aid (PtDA) targeted at patients with recurrent high-grade gliomas. Based on existing knowledge and the International Patient Decision Aids Standards, the PtDA was developed through an iterative process. The PtDA was alpha-tested by potential users to assess its acceptability and usability. The development team comprised three clinicians, two patients, two family members, and a researcher. The fifth version of the PtDA was submitted to the alpha test. Eleven patients, nine family members, and eleven clinicians assessed the PtDA and found it acceptable. Three changes were made during the alpha test. Most participants perceived the PtDA to prepare patients for decision making and improve consultations. The involvement of potential users was emphasized during the development and alpha test process. The PtDA was assessed as useful and acceptable by patients, family members, and clinicians in the decision-making situation of recurrent high-grade glioma.
Development of a Questionnaire to Assess the Mothers Knowledge and Attitude towards Hearing Loss in Children

Objective: The support from mothers towards children with hearing loss is important for an early identification, diagnosis and intervention. Attempts at exploring the existing knowledge and attitude among mothers are crucial, which may lead to a greater benefit for the children and overall satisfaction for the child and the family. Thus, the present study was attempted to explore the knowledge and attitude of mothers towards children with hearing loss through the use of a valid and reliable questionnaire developed for this purpose in Malay-language. Methods: Questionnaire was developed based on past literature on knowledge, attitude and focus group discussions (FGD) which involved a representative from primary health care providers, ear, nose and throat (ENT) surgeon and audiologists. Translations follow a forward-backward procedure, independently carried out by two native-speakers of the target language. Translated questionnaires have undergone a pilot testing which involved 30 Malaysian mothers who visited the health clinics. The internal consistency of the two main domains (knowledge and attitude) was computed by the Cronbach’s Alpha coefficient to assess the reliability of the newly developed questionnaire. Results: The range of Cronbach’s Alpha showed a considerable consistency for both the knowledge and attitude with Cronbach’s Alpha of 0.77 and 0.78, respectively. Conclusion: The questionnaire regarding the knowledge and attitude of mothers towards children with hearing loss is a reliable and valid instrument. This research introduced the Malay-language version of the knowledge and attitude questionnaire as the first formal validated questionnaire and confirmed a high reliability and validity for the evaluation of mother’s knowledge and attitude towards children with hearing loss.