Miracle-dz/UniFAR-FTUs huggingface dataset:
The known knowns and known unknowns of vaccine-induced thrombotic thrombocytopaenia

the role of platelets, coagulation, and inflam-mation in the development of thrombosis, atherosclerosis, and infarction. development numerous of novel biomarker and molecular imaging strategies for thrombosis, inflammation, and unstable atherosclerotic plaques using magnetic resonance imaging, positron emission tomogra-phy, computed tomography, ultrasound, and fluorescence imaging as well as innovative biotechnological anti-thrombotic and anti-inflammatory approaches.
Evaluating the performance of the MMPI-3 over-reporting scales: Sophisticated simulators and the effects of comorbid conditions

Abstract Objective We examined the utility of the Minnesota Multiphasic Personality Inventory-3 (MMPI-3) to detect feigned over-reporting using a symptom-based coaching simulation design across a control group and three diagnostic conditions: posttraumatic stress disorder (PTSD), minor traumatic brain injury (mTBI), and comorbid PTSD and mTBI. Method Participants were310 college students who wererandomly assigned to one of the four conditions. For participants in the feigning conditions, they were provided with a descriptionof their respective disorder condition throughout the duration of the session and asked to feign according to their condition while completing the MMPI-3. Results MMPI-3 over-reporting scales perform well at classifying feigning. There is low sensitivity, high specificity, and effect magnitudes are medium to large range (1.12 − 2.47). There are no differences in scales assessing over-reporting between diagnostic conditions with dissimilar symptoms. Conclusions Findings provide initial support for the use of the MMPI-3 overreporting scales for detecting feigned PTSD, mTBI, and comorbid PTSD and mTBI. Further, individuals feigning different disorders, namely PTSD, mTBI, and comorbid PTSD and mTBI, feign predominantly general psychopathological symptoms, making Fp the strongest scale in terms of detecting these feigned disorders. Future research will benefit from establishing relevant diagnostic comparison groups to contrast with this study and utilizing known-group designs withboth PVT and SVT administration.
Prevalence of urinary tract infections, associated risk factors, and antibiotic resistance pattern of uropathogens in young women at Noakhali, Bangladesh

Urinary tract infection (UTI) remains one of the most common infections among young females diagnosed in developing countries. The emergence of antibiotic resistance among uropathogens is a global problem. This study aimed to determine the prevalence and resistance of antibiotics to uropathogens, and to understand the relationship of uropathogens to multiple clinical, social and demographic factors of young female students in a university in Bangladesh. Four hundred freshly voided midstream urine samples collected from young female students and several clinical and socio-demographic variables along with UTI symptomatic queries were determined. Bacterial isolation was carried out by using standard and specific microbiological techniques and antimicrobial susceptibility pattern was determined by Kirby Bauer Disc diffusion method. Among the tested specimens, 106 (26.5%) has significant bacterial growth, 60 (57%) were symptomatic, and 46 (43%) were asymptomatic. The highest uropathogen was recorded within the age group of 24-25 years (51%). There was a significant association (p < 0.05) of uropathogen with anatomical abnormality of urinary tract, water sources for food preparation and bathing, and the number of person sharing the same toilet. Most predominantly isolated bacteria were E. coli (32.08%) followed by Staphylococcus saprophyticus (24.53%), Streptococcus spp. (16.04%), Klebsiella spp. (14.15%), Aceinetobacter spp. (4.72%), Citrobacter spp. (2.83%), Enterobacter spp. (2.83%), and Pseudomonas spp. (2.83%). In the effectiveness of each treated antibiotic, urinary pathogens were highly resistant towards nalidixic acid (80.19%), ampicillin (75.73%), cephalexin (70%) and azithromycin (68.48) while against imipenem (7.94%) and amikacin (18.87%) least resistancy were found. A good understanding of the etiology of uropathogens will assist the general practitioner to identify the correct therapeutic strategy for the proper management of UTIs. Asian J. Med. Biol. Res. 2021, 7 (2), 202-213
Group cognitive remediation therapy prior to behavioral weight loss treatment for adults with severe obesity: A randomized clinical trial (CRT study).

Objective: Individuals with obesity show executive dysfunctions that have been implicated in weight management failure. Initial evidence suggests that cognitive remediation therapy (CRT) conducted after behavioral weight loss (BWL) treatment improves weight loss and executive function, but efficacy for CRT conducted before BWL treatment is unknown. This study investigated whether group CRT in adults with Class II or III obesity (body mass index, BMI≥35 kg/m2) improves weight loss, executive function, weight management behavior, and mental and physical health in real-world group BWL treatment. Method: In this prospective single-center, assessor-blind trial (DRKS00009333), 270 adults with Class II and III obesity (age 44.5 ± 12.8 years, BMI 45.6 ± 6.9 kg/m2, and 68.9% women) were randomized to CRT with 8 group sessions over 2 months versus no treatment control, followed by routine BWL treatment of up to 12 months for both groups. The primary outcome was percent weight change at 6 months. Secondary outcomes included executive functions, weight management behaviors, and mental and physical health. Results: In intent-to-treat analyses, overall weight loss after 6 months was 1.2%, 95% CI [-2.0% to -0.4%], p = . 002. The difference between arms was 0.4%, 95% CI [-1.1% to 1.8%], p = . 629, Cohen's d = 0.09, after 6 months and 0.3%, 95% CI [-1.5% to 2.2%], p = . 721, Cohen's d = 0.01, after 12 months. Improvements in most secondary outcomes including executive functions were seen at most time points, however, without differences between arms. Conclusions: Group CRT versus no treatment prior to real-world BWL treatment in adults with Class II and III obesity does not improve weight loss. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Evaluation of randomly amplified polymorphic DNA-polymerase chain
 reaction method for the identification of eighteen lyophilized probiotics
 commercially available

Identification of probiotics is crucial to ensure the quality of food products manufactured at the industrial scale. Although various techniques have been introduced for bacterial identification, randomly amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) is generally accepted as a conventional method for bacterial identification. In this study, RAPD-PCR method was evaluated for the identification of eighteen commercial probiotic strains. In results, cellular and product (lyophilized) forms of each probiotic strain were successfully identified based on band intensities and size of the amplified genes. Therefore, RAPD-PCR method may be applied for the identification of lyophilized probiotics commercially available.
Roles of glomerular endothelial hyaluronan in the development of proteinuria

Vascular endothelial cells are covered with glycocalyx comprising heparan sulfate, hyaluronan, chondroitin sulfate, and associated proteins. Glomerular endothelial glycocalyx is involved in protecting against induction of proteinuria and structural damage, but the specific components in glycocalyx that represent therapeutic targets remain unclear. Anti‐vascular endothelial growth factor (VEGF) therapy is associated with an increased risk of glomerular endothelial injury. This study investigated whether hyaluronan could provide a therapeutic target to protect against proteinuria. We conducted ex vivo and in vivo experiments to explore the effects of degrading glomerular hyaluronan by administering hyaluronidase and of supplementation with hyaluronan. We investigated hyaluronan expression using biotin‐labeled hyaluronan‐binding protein (HABP) in human kidney specimens or serum hyaluronan in endothelial injuries under inhibition of VEGF signaling. We directly demonstrated hyaluronan in glomerular endothelial layers using HABP staining. Ex vivo and in vivo experiments showed the development of proteinuria after digestion of hyaluronan in glomerular capillaries. Supplementation with hyaluronan after hyaluronidase treatment suppressed proteinuria. Mice in the in vivo study developed albuminuria after intraperitoneal injection of hyaluronidase with decreased glomerular hyaluronan and increased serum hyaluronan. In human kidneys with endothelial cell dysfunction and proteinuria due to inhibition of VEGF, glomerular expression of hyaluronan was reduced even in normal‐appearing glomeruli. Serum hyaluronan levels were elevated in patients with pre‐eclampsia with VEGF signaling inhibition. Our data suggest that hyaluronan itself plays crucial roles in preventing proteinuria and preserving the integrity of endothelial cells. Hyaluronan could provide a therapeutic target for preventing glomerular endothelial glycocalyx damage, including VEGF signaling inhibition.
Perceptions and comparison of bedside teaching among final year students of public and private medical colleges of Peshawar

Abstract Introduction: Bedside teaching is an important but declining strategy in medical education. The regulatory authority’s insistence on structure of an institute needs be supplemented with quality of bedside teaching. The objective of this study was to find perceptions and compare bedside teaching among students of public and private medical colleges of Peshawar. Methods: A cross-sectional study was conducted at four medical colleges of Peshawar during the month of February 2020. A Likert scale tool with 30 items and four subscales; physical environment, patient’s comfort and student attitude, teaching session and teaching fellow was filled by 242 students. Mean score for each question and each subscale was calculated for each institute for perceptions. Mean score of two public and two private institutes for each subscale was compared by unpaired t-test. Results: Physical environment mean score was highest at Khyber Girls Medical College Peshawar (2.97±0.50). Patients’ comfort and students’ attitude mean score was approximately equal in four institutes. In teaching session, the highest mean score was reported by Khyber Girls Medical College and was lowest by Khyber Medical College. For teaching fellow, mean score was highest at Khyber Girls Medical College (3.70±0.67) and lowest at Kabir Medical College (2.85±0.55). For physical environment (public 2.87±0.48 vs. private 2.59±0.60) and teaching fellow scale (public 2.87±0.48 vs. private2.59±0.60) there was highly significant difference (p=0.0001). Conclusion: Mean score in four subscales are comparable in four institutes with some variation but there are significant differences between public and private institutes in physical environment and teaching fellow subscales. There are some consistencies and conflicts with regional and international literature. This needs in-depth qualitative exploration. Bedside teaching, Medical education, Perception, Physical environment, Teaching session, Teaching fellow
Radiosensitization of calreticulin‐overexpressing human glioma cell line by the polyphenolic acetate 7, 8‐diacetoxy‐4‐methylcoumarin

Calreticulin (CRT), an endoplasmic reticulum–resident protein generally overexpressed in cancer cells, is associated with radiation resistance. CRT shows higher transacetylase activity, as shown by us earlier, in the presence of the polyphenolic acetates (like 7, 8‐diacetoxy‐4‐methylcoumarin, DAMC) and modifies the activity of a number of proteins, thereby influencing cell signaling.
Association of Respiratory Syncytial Virus Infection and Underlying Risk Factors for Death Among Young Infants Who Died at University Teaching Hospital, Lusaka Zambia

Abstract Background Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections and child mortality. While RSV disease burden is highest in low- and middle-income countries, most knowledge about risk factors for fatal RSV disease comes from high-income settings. Methods Among infants aged 4 days to <6 months who died at University Teaching Hospital in Lusaka, Zambia, we tested nasopharyngeal swabs obtained postmortem for RSV using reverse transcriptase–quantitative polymerase chain reaction. Through a systematic review of death certificates and hospital records, we identified 10 broad categories of underlying medical conditions associated with infant deaths. We used backward-selection models to calculate adjusted and unadjusted risk ratios (RRs) for the association between each underlying condition and RSV status. Results From 720 infant deaths, 6% (44) were RSV-positive, 70% were <4 weeks old, and 54% were male. At least 1 underlying condition was found in 85% of infants, while 63% had ≥2. Prematurity/low birth weight (53% [384]) and complications of labor and delivery (32% [230]) were the most common conditions. Congenital cardiac conditions were significantly associated with an increased risk of RSV infection (4%, 32; adjusted RR: 3.57; 95% CI: 1.71–7.44). No other underlying conditions were significantly associated with RSV. Conclusions Other than congenital cardiac conditions, we found a lack of association between RSV and underlying risk factors. This differs from high-income settings, where RSV mortality is concentrated among high-risk infants. In this population, birth-related outcomes are the highest mortality risk factors. Improved neonatal care remains crucial in the fight against neonatal mortality.
FAT AND TOCOPHEROL CONTENT IN THE SEEDS OF RED AMARANTH IN CONDITIONS OF DIVERSIFIED FERTILIZATION WITH MACROELEMENTS

The aim of the study was to determine the content of fat and tocopherols in the seeds of Polish cultivars of red amaranth (Amaranthus cruentus L.) – Rawa and Aztek – under the influence of varied macroelement fertilization in the environmental conditions of the Zamość region of south-eastern Poland. In a three-year field experiment (2013–2015) set up in a randomized split-plot design, red amaranth was grown as a test plant at wide row spacing, on good wheat complex soil, in south-eastern Poland (N – 50º71', E – 23º04'). The field experiment had three variables: the weather in the years of research; four combinations of NPK application and two cultivars of the test plant – Rawa and Aztek. The research showed that the factor that most influenced the content of crude fat in the amaranth seeds was the cultivar, followed by the combination of NPK fertilization. The amount of α-tocopherol and total tocopherol depended significantly on the genetic factor and the fertilization combination, while the amount of β-tocopherol was determined more by fertilization than by the cultivar. The content of γ-tocopherol and δ-tocopherol was dependent only on the cultivar.
INTERACTIVE VIDEOS AS GEOSPATIAL INTERFACES: A CASE STUDY FOR REGIONAL PROMOTION

In this paper we discuss the potential of interactive video as an interface to geospatial information, and demonstrate our findings in a case study driven by goals of promoting a region for tourism and for preventing brain drain. Use of video is controversial due to various technical and human-centric debates; on the one hand, they offer unique qualitative insights as they enable a certain level of immersion via walk-throughs and fly-throughs and they are considered attractive by viewers, on the other hand, they are complex because they contain unfiltered (possibly too much) information that may be irrelevant to the goals of the users, and require careful consideration from computational and bandwidth concerns. We examine these arguments from the literature briefly, and demonstrate our case study in which we have embedded and overlain statistical and other local information interactively over drone footage, and measured levels of usability and user engagement using standardized scales. Our implementation and design choices are detailed in the article. Our small user experiment (n=6) suggests high levels of usability, desirability and engagement by our participants, leading to the hypothesis that video is an attractive medium and indeed has strong potential for regional promotion, given that the computational and cognitive issues are taken into account. 1* Corresponding author: arzu.coltekin@fhnw.ch
Day-to-day measurement of physical activity and risk of atrial fibrillation

Abstract Aims The aim of this study was to investigate the association between within-individual changes in physical activity and onset of atrial fibrillation (AF). Methods and results A total of 1410 participants from the general population (46.2% women, mean age 74.7 ± 4.1 years) with risk factors but with no prior AF diagnosis underwent continuous monitoring for AF episodes along with daily accelerometric assessment of physical activity using an implantable loop recorder during ≈3.5 years. The combined duration of monitoring was ≈1.6 million days, where 10 851 AF episodes lasting ≥60 min were detected in 361 participants (25.6%) with a median of 5 episodes (2, 25) each. The median daily physical activity was 112 (66, 168) min/day. A dynamic parameter describing within-individual changes in daily physical activity, i.e. average daily activity in the last week compared to the previous 100 days, was computed and used to model the onset of AF. A 1-h decrease in average daily physical activity was associated with AF onset the next day [odds ratio 1.24 (1.18–1.31)]. This effect was modified by overall level of activity (P < 0.001 for interaction), and the signal was strongest in the tertile of participants with lowest activity overall [low: 1.62 (1.41–1.86), mid: 1.27 (1.16–1.39), and high: 1.10 (1.01–1.19)]. Conclusions Within-individual changes in physical activity are associated with the onset of AF episodes as detected by continuous monitoring in a high-risk population. For each person, a 1-h decrease in daily physical activity during the last week increased the odds of AF onset the next day by ≈25%, while the strongest association was seen in the group with the lowest activity overall. Clinical Trial Registration ClinicalTrials.gov, identifier: NCT02036450.
The Effects of Group Sand play on the Psychological Health and Resilience of Street Children and Adolescents in Uganda

The authors analysed the effects of group Sandplay therapy on adolescents' psychological health and resilience in a mixed-method research. They explored and categorized the themes these adolescents expressed during therapy. Fifteen children (n=15) were recruited for the study; (Boarding school children = 5; Day school children = 5; Street children = 5). The selection process was conducted in cooperation with an orphanage in Kabale, Uganda. The children who participated in the study underwent a forty-five-minute sand play therapy every week for nine weeks. The SDQ and RCADS were administered to the groups both pre- and post-intervention, with the data entered and analysed using SPSS. Group sandplay was found to significantly decrease the adolescents' internalizing problems such as anxiety and depression, while their resilience had also significantly improved. The narrative analysis, in turn, yielded seven themes: basic needs; community-love-celebration; giving help-leadership-empowerment; security-danger, recreation-self-development-self-nurturance, education, and seeking help-faith.
Implications of surface flooding on airborne estimates of snow depth on sea ice

Abstract. Snow depth observations from airborne snow radars, such as the NASA's Operation IceBridge (OIB) mission, have recently been used in altimeter-derived sea ice thickness estimates, as well as for model parameterization. A number of validation studies comparing airborne and in situ snow depth measurements have been conducted in the western Arctic Ocean, demonstrating the utility of the airborne data. However, there have been no validation studies in the Atlantic sector of the Arctic. Recent observations in this region suggest a significant and predominant shift towards a snow-ice regime caused by deep snow on thin sea ice. During the Norwegian young sea Ice, Climate and Ecosystems (ICE) expedition (N-ICE2015) in the area north of Svalbard, a validation study was conducted on 19 March 2015. This study collected ground truth data during an OIB overflight. Snow and ice thickness measurements were obtained across a two-dimensional (2-D) 400 m × 60 m grid. Additional snow and ice thickness measurements collected in situ from adjacent ice floes helped to place the measurements obtained at the gridded survey field site into a more regional context. Widespread negative freeboards and flooding of the snowpack were observed during the N-ICE2015 expedition due to the general situation of thick snow on relatively thin sea ice. These conditions caused brine wicking into and saturation of the basal snow layers. This causes the airborne radar signal to undergo more diffuse scattering, resulting in the location of the radar main scattering horizon being detected well above the snow–ice interface. This leads to a subsequent underestimation of snow depth; if only radar-based information is used, the average airborne snow depth was 0.16 m thinner than that measured in situ at the 2-D survey field. Regional data within 10 km of the 2-D survey field suggested however a smaller deviation between average airborne and in situ snow depth, a 0.06 m underestimate in snow depth by the airborne radar, which is close to the resolution limit of the OIB snow radar system. Our results also show a broad snow depth distribution, indicating a large spatial variability in snow across the region. Differences between the airborne snow radar and in situ measurements fell within the standard deviation of the in situ data (0.15–0.18 m). Our results suggest that seawater flooding of the snow–ice interface leads to underestimations of snow depth or overestimations of sea ice freeboard measured from radar altimetry, in turn impacting the accuracy of sea ice thickness estimates.
Multiple strategies of plant colonization by beneficial endophytic Enterobacter sp. SA187.

Although many endophytic plant growth-promoting rhizobacteria have been identified, relatively little is still known about the mechanisms by which they enter plants and promote plant growth. The beneficial endophyte Enterobacter sp. SA187 was shown to maintain productivity of crops in extreme agricultural conditions. Here we present that roots of its natural host (Indigofera argentea), alfalfa, tomato, wheat, barley and Arabidopsis are all efficiently colonized by SA187. Detailed analysis of the colonization process in Arabidopsis showed that colonization already starts during seed germination, where seed-coat mucilage supports SA187 proliferation. The meristematic zone of growing roots attracts SA187, allowing epiphytic colonization in the elongation zone. Unlike primary roots, lateral roots are significantly less epiphytically colonized by SA187. Root endophytic colonization was found to occur by passive entry of SA187 at lateral-root bases. However, SA187 also actively penetrates the root epidermis by enzymatic disruption of plant cell wall material. In contrast to roots, endophytic colonization of shoots occurs via stomata, whereby SA187 can actively re-open stomata similarly to pathogenic bacteria. In summary, several entry strategies were identified that allow SA187 to establish itself as a beneficial endophyte in several plant species, supporting it's use as a plant growth-promoting bacterium in agriculture systems. This article is protected by copyright. All rights reserved.