Miracle-dz/UniFAR-FTUs huggingface dataset:
Salvage Stereotactic Radiotherapy for Recurrent Glioblastoma Multiforme: Clinical Outcomes from a Multi-Institutional Registry

**Objectives:** The purpose of this study was to evaluate the potential benefits of dose escalation for overall survival (OS) and assess related toxicities following stereotactic radiotherapy (SRT) for recurrent glioblastoma multiforme (GBM) patients. **Methods:** The RSSearch® Patient Registry was screened for patients with recurrent GBM treated with SRT between June 2007 to July 2015. The impact of potential prognostic factors on OS were evaluated using the Kaplan-Meier method and continuous log rank analysis. Prognostic factors examined included prescription dose, GTV, RPA class, initial KPS, patient age, tumor location, and single vs. multifocal recurrence. Logistic regression was utilized to evaluate the relationship between prescription dose and toxicities (graded by CTCAE guidelines). **Results:** Forty-seven patients treated with SRT (11 with 3 fractions and 36 with 5 fractions) were identified. Median OS for the cohort was 6.62 months (range: 0.33 months - 38.9 months). Of prognostic factors examined, GTV ≥ 25 cc trended towards poorer prognosis (median OS of 6.23 months vs. 8.63 months; p = 0.0597) as did initial KPS < 70% (2.63 months vs. 8.3 months; p = 0.1168). Patients treated with SRT of 5 fractions and prescription doses ≥ 30 Gy had a higher median OS (8.96 months vs. 5.65 months; p = 0.0904). However, significant survival benefits were not noted from SRT of 5 fractions and prescription doses ≥ 35 Gy (7.61 months vs. 6.47 months; p = 0.4361). Roughly 13% of patients reported side effects such as fatigue, alopecia, and mental status changes with all reported toxicities being either Grade 1 or 2. Doses ≥ 35 Gy for patients treated with SRT of 5 fractions were associated with increased side-effect incidence (p = 0.049). **Conclusion:** Salvage SRT was relatively well-tolerated and resulted in similar survival outcomes that have been previously reported in the literature. Dose escalation seems to trend towards better outcomes for SRT of 5 fractions. Prospective studies are warranted to examine the possible benefits of novel adjuvant therapies in combination with SRT given the poor prognosis of recurrent GBM.
Depressão e ansiedade na consulta de clínica geral/medicina familiar.

The aim of this work was to study depression and anxiety in outpatients of Family Practice, namely: definition of cases, caseness, point-prevalence, clinical features, correlations with social demographic factors and identification of risk groups for those psychological disorders. Therapeutic attitudes displayed by family practitioners were also evaluated. The results of the study reveal a high prevalence of depression in family medicine settings and a relative tendency of family doctors to underdiagnose case of depression. Such an evidence allows the authors to conclude that steps should be taken in order to provide training programs for family practitioners and to plan appropriate treatment programmes at public Health Centres.
PROMOTION VS. EDUCATION IN CHOOSING “REAL FOOD”

The global agro-industrial system contributes to an abundance of human and ecological health problems from social injustices and public health issues to global warming and ecological degradation. In response to these problems, universities across the country are joining the Real Food Challenge (RFC). The RFC is a national student-driven organization that defines “Real Food” as possessing at least one of the following four attributes: local, fair, ecologically-sound, and/or humane. By mobilizing the power of students on college campuses, the RFC aspires to shift up to one billion dollars in dining purchasing towards “Real Food” by the year 2020. One key element for the continued success of the RFC is a better understanding of factors affecting college student food choice. Our research explores these factors as well as the types of interventions that will most effectively impact them. Both educational and social marketing strategies were found to effectively increase the importance of Real Food factors affecting college student food choice decisions. In addition, the overwhelming majority of student participants believe that their personal food choices can have an impact on moving the larger industrial food system towards sustainability. Identifying strategies that encourage students to choose more “Real Food” can provide administrations with the necessary support to increase sustainable food purchasing while fueling the RFC on its industry-shifting path towards a more sustainable food system overall.
Closed versus open lateral internal anal sphincterotomy in a chronic anal fissure

Background: Anal fissure is a common proctological problem, which presents with pain in the anal region during and after defecation. The aim of the study was to determine the best technique for surgical treatment of chronic anal fissure patients. Methods: The study was designed as a prospective randomized study. The study was conducted in surgical unit, K.R. Hospital, MMCRI, Mysore, India from January 2015 to June 2016. A total of 100 patients undergoing surgery were divided into two groups. In group A there were 50 patients who were treated by closed lateral internal anal sphincterotomy, and in group B there were 50 patients who were managed by open lateral internal anal sphincterotomy method. Patients were followed up for 6 months following surgery to observe for pain, bleeding, infection, incontinence, and recurrence. The exclusion criteria were patients who had in addition haemorrhoids or any other anorectal diseases. Results: There was acceptable difference in postoperative acute complications between the two methods of internal anal sphincterotomy. However, in group A, three patients (6%) versus 10 (20%) were complicated with incontinence postoperatively, whereas the recurrence rate was 4 versus 4% in group A versus group B, respectively (P = 0.015). Conclusions: There was significant difference between closed and open methods of lateral internal sphincterotomy in recurrence rate, healing rate, and other complications. Closed lateral internal sphincterotomy is treatment of choice for chronic anal fissure and can be done effectively and safely with acceptable rate of complications. Our recommendations are that closed technique should be adopted by experienced surgeons and Trainee should be initially trained by open technique then be shifted to closed technique.
The Community Code Verification Exercise for Simulating Sequences of Earthquakes and Aseismic Slip (SEAS)

Numerical simulations of sequences of earthquakes and aseismic slip (SEAS) have made great progress over past decades to address important questions in earthquake physics. However, significant challenges in SEAS modeling remain in resolving multiscale interactions between earthquake nucleation, dynamic rupture, and aseismic slip, and understanding physical factors controlling observables such as seismicity and ground deformation. The increasing complexity of SEAS modeling calls for extensive efforts to verify codes and advance these simulations with rigor, reproducibility, and broadened impact. In 2018, we initiated a community code-verification exercise for SEAS simulations, supported by the Southern California Earthquake Center. Here, we report the findings from our first two benchmark problems (BP1 and BP2), designed to verify different computational methods in solving a mathematically well-defined, basic faulting problem. We consider a 2D antiplane problem, with a 1D planar vertical strike-slip fault obeying rate-and-state friction, embedded in a 2D homogeneous, linear elastic half-space. Sequences of quasi-dynamic earthquakes with periodic occurrences (BP1) or bimodal sizes (BP2) and their interactions with aseismic slip are simulated. The comparison of results from 11 groups using different numerical methods show excellent agreements in long-term and coseismic fault behavior. In BP1, we found that truncated domain boundaries influence interseismic stressing, earthquake recurrence, and coseismic rupture, and that model agreement is only achieved with sufficiently large domain sizes. In BP2, we found that complexity of fault behavior depends on how well physical length scales related to spontaneous nucleation and rupture propagation are resolved. Poor numerical resolution can result in artificial complexity, impacting simulation results that are of potential interest for characterizing seismic hazard such as earthquake size distributions, moment release, and recurrence times. These results inform the development of more advanced SEAS models, contributing to our further understanding of earthquake system dynamics.
Albendazole Induced Rupture Of Pulmonary Hydatid Cysts

Six patients of pulmonary hydatid disease who developed rupture of their cysts upon treatment with albendazole started prior to percutaneous aspiration (n=4) and /or surgery (n=2) are presented. The patients had been put on albendazole for sterilization of the cysts prior to the procedure. The rupture resulted is sudden cough (n= 6), breathlessness (n=3), chest pain ( n= 2) and wheezing (n= 2) accompanied by expectoration of a salty fluid containing whitish membrane like structures. The expectorated material was found to contain hydatid scolices in each case. The rupture alongside continued albendazole therapy was curative in 2 cases and a regrowth was observed in 5 cysts. No spillage hydatidosis was seen. Albendazole therapy can cause a rupture in some patients with pulmonary hydatid disease and should be suspected in any such patient who presents with sudden onset respiratory symptoms. The rupture may be curative in some but the patients need to be followed for regrowth or development of spillage induced secondary hydatidoses.
An Adaptation Experience of Male Nurses at General Nursing Unit

Purpose: This study was conducted to examine the adaptation experience of male nurses working in general wards. Methods: Experiential data was collected from 16 general ward nurses through in-depth interviews. Participants were selected from male nurses working in the general wards with over one year of clinical experience at a tertiary university hospital. The main question was “Can you describe your adaptation experience in the general ward as a nurse? ” All interviews were recorded and transcribed, then analyzed using Colaizzi’s method. Results: Four categories were derived from the analysis: ‘difficulties from task adaptation by characteristics’, ‘limited nursing situation and circumstance as a male nurse’, ‘efforts to adapt at general nursing unit', and ‘self-worth, and worry about something as a male nurse’. Conclusion: Male nurses had a difficulty adapting to work in wards due to lack of multi-tasking skills, as well as some social prejudice or negative views on male nurses. Establishing reasonable guidelines for male nurses in practice, promoting their responsibilities to patients, developing mentoring programs, and reassessing the policy of assigning male nurses to general wards are recommended to help in better adaptation.
Comparative Analysis of the Effect between FES, RUSSA and AUSSIE Therapeutic Currents in Individuals with Hypertonia Spastic Post Stroke Case Study

The effectiveness of treatment by means of electro-stimulation in patients with an increase of spasticity in the affected hemibody after a stroke has been presented in several efficiency and the median frequency, surface electromyography was applied. In this case, study considering we hold a small sample we utilised a comparison of the real values for each test, not conducting statistic tests. After a re-evaluation of the Ashworth's Modified scale no differences were found between the initial and final scores, In the Berg’s Balance Scale within both groups there was an improvement in equilibrium and after the application of the surface electromyography there was a lower muscular activity in the AG - AUSSIE group, better muscular efficiency in the AG – AUSSIE group and a decrease in median frequency in the FG - FES group. Up until the present moment, it may be noted that the current methods are effective, especially AUSSIE. electromyography; Application of RUSSA, FES or current
Lupus erythematosus, thyroiditis, alopecia areata and vitiligo – A multiple autoimmune syndrome type 3 case presentation

215 How to cite this article: Tatu AL, Nwabudike LC. Lupus erythematosus, thyroiditis, alopecia areata and vitiligo A multiple autoimmune syndrome type 3 case presentation. Our Dermatol Online. 2017;8(2):215-216. Submission: 31.01. 2017; Acceptance: 03.03. 2017 DOI: 10.7241/ourd.20172. 58 Lupus erythematosus, thyroiditis, alopecia areata and vitiligo A multiple autoimmune syndrome type 3 case presentation
A study of birth preparedness of women in Jamnagar district, Gujarat, India -

Background: About 800 women die every day from preventable causes related to pregnancy and child birth globally. Birth-preparedness is a strategy developed by the maternal and neonatal health programme of JHPIEGO for addressing the three main delays at various stakeholder levels. Present study is an attempt to assess the level of birth preparedness of pregnant women in rural area of Jamnagar district and various factors associated with it. Methods: It was a cross-sectional study conducted during October 2011 to March 2012. Total live births in a year 2011 were 39943.90 and Taking 1% of total births ≈ 400, Adding 10% of non-response rate, total sample size was 440. Total 450 study subjects were chosen. The study-subjects were divided in 1) current pregnant women and 2) recent delivered women. A pretested semi-structured questionnaire was used to interview women, chosen for the study using multistage random sampling technique and data was analysed by Epi Info. Results: It was found that only about one third of women i.e. 32.2% were prepared for birth and 67.8% women were not prepared. Out of 450 women, it was found that 86.2% of them planned for the skilled birth attendant, 59.6% women planned for saving money, about one third of women i.e. 37.6% had planned for transportation and only 2.7% women had planned for blood donor in case of emergency. Religion Hindu, literacy of women and their husbands, higher socio-economic status, advice given during pregnancy were some positive factors associated with birth preparedness. Conclusions: The level of birth preparedness in study subjects was found very low. Sincere efforts are required to identify this gap and reducing the same.
Body Mass Index, Prevalence and Predictors of Obesity in Urban and Rural Communities in Abia State South Eastern Nigeria

Background and objectives: Obesity is assuming an epidemic dimension globally. Currently more than 1.9 billion adults are overweight - and at least 600 million of them are obese. There is dearth of community based study on prevalence and predictors of obesity in Nigeria, and none from Abia state in particular, prompting us to undertake the study. Material and Methods: This was a cross-sectional study, aimed at ascertaining the prevalence and predictors of obesity in the state. The study subjects were recruited from the three senatorial zones in the state. In each of the zones, an urban and a rural community were randomly selected. The World Health Organization Stepwise Approach to Surveillance of chronic disease risk factors was used. Body mass index, anthropometric measurements, and other relevant data were also collected. Results: Overweight was present in 716 (28.2%) and obesity was present in 313 (12.3%) of the subjects. Ninety five (30.4%) of the obese subjects were men, while 281(69.7%) were women. One hundred and eighty (57.5%) of the obese subjects were urban dwellers, while 133 (42.4%) were rural dwellers. The women and urban dwellers were significantly more obese than men and rural dwellers respectively (p<0.001). Using multiple logistic regression analysis two variables predicted obesity in the study population. These were gender (OR=2.83, 95%CI 2.150-3.717, P=<0.001), and locality (OR=1.40, 95%CI 1.154-1.979, P=0.027). Conclusion: The prevalence of obesity in the state is significantly high and gender and locality are predictors of obesity in southeast Nigeria.
Women in Science and Technology

A Working Party on Women in Science and Technology has been set up by the British Federation of University Women to study the part women can play in the present-time shortage of trained people. We felt that we should look first to the schools and, realizing the lack of readily accessible information about careers, we published a booklet,Opportunities for Women and Girls in Science and Technologintended for the use of school-girls and their teachers and parents. This pamphlet was received with enthusiasm and the first edition was quickly sold out.
Native tree and shrub canopy facilitates oak seedling regeneration in semiarid woodland

Oaks are currently declining worldwide due to a multitude of threats. Woodland management is often heavily focused on thinning and burning non-target species to reduce competition and promote oak dominance in the overstory. These techniques have typically been developed in temperate regions, such as eastern USA forests, but whether they are the most effective strategy for promoting oak regeneration in semiarid woodlands has not been sufficiently examined. We conducted our study on the eastern Edwards Plateau in central Texas, where several oak species are codominant with Ashe juniper over karst limestone terrane. These juniper-oak woodlands provide habitat for many endemic species and play an essential role in the maintenance of key aquifers. A history of canopy clearing and a severe drought in 2011 generated patches of living and dead juniper-oak canopy interspersed with canopy gaps in our study area. In November 2013, we planted 200 shin oak acorns in each of three habitat treatments, replicated six times: i) live canopy, ii) dead canopy, iii) open invasive grassland. We monitored emergence and survival each year, harvesting five seedlings from each replicate in October 2017 to assess shoot height, rooting depth, biomass, ectomycorrhizal colonization, and foliar nutrients. Canopy trees, living or dead, significantly enhanced seedling emergence and survival. Survival was positively associated with increasing Ashe juniper and oak basal area, shrub cover, and soil organic matter, and negatively associated with increasing canopy gap size (complete mortality in gaps >220 m2). Seedling biomass increased significantly in dead and open treatments along with foliar nutrients N, P and S (dead treatments) or S and Fe (open treatments), whereas ectomycorrhizal colonization and foliar nutrients Ca, Mg, and Mn increased under living canopy. Our findings suggest that oak regeneration in these juniper-oak woodlands closely resembles that of Mediterranean regions, where canopy facilitates seedling survival. Both living and dead trees and shrubs enhanced oak regeneration, with seedling survival depending on proximity to larger trees, living roots, shrubs, and juniper-oak canopy. Planting acorns under canopy is an inexpensive, sustainable, and effective restoration practice in drought-prone ecosystems.
Urgences abdominales digestives non traumatiques chez les sujets âgés au CHU de Cocody à Abidjan, Côte d'Ivoire: étiologies et résultats thérapeutiques

Objectifs. Decrire les etiologies des urgences abdominales digestives non traumatiques chez les sujets âges et rapporter les resultats de leur traitement. Materiel et methodes. Etude retrospective de dossiers de patients âges de 60 ans et plus operes en urgence d'une affection abdominale digestive non traumatique au CHU de Cocody a Abidjan d'aout 1998 a juillet 2008. L'analyse a porte sur les parametres epidemiologiques, diagnostics, therapeutiques et les resultats apres traitement. Resultats. La serie etait constituee de 137 patients d'un âge moyen 68,3 ans (extremes: 60 et 93 ans) . On notait 84 tares medicales chez 69 patients. Les pathologies rencontrees etaient les hernies etranglees (n=40), les abces de la paroi (n=6), les peritonites aigues diffuses (n=29), les occlusions intestinales aigues (n=32), les appendicites aigues (n=23), les cholecystites aigues lithiasiques (n=6) et la rectorragie par saignement de diverticules coliques (n=1 ). L'hospitalisation a dure 7,7 jours (extremes 2 et 23 jours). La suppuration parietale (n=14), les complications des stomies (n=7), la fistule digestive (n=4), l'hematome scrotal (n=5) et l'evisceration post-operatoire (n=2) etaient les principales complications post-operatoires. Quatorze deces ont ete observes (mortalite 10,21%). La principale cause des deces etait la peritonite postoperatoire (n=6). Conclusion. Dans notre pratique, les urgences chirurgicales digestives non traumatiques des patients âges sont en general des complications d'affections preexistantes negligees ou meconnues. Leur pronostic est fonction du stade evolutif de l'affection, du traitement chirurgical initial et de la decompensation ou non de tares que portent ces patients.
Obesity and fractures: between black and white aspects.

Obesity, a worldwide medical problem, associates a large panel of disorders but traditionally osteoporosis was not considered one of them. This mini-review targets human and animal studies related to this topic. DXA is the golden standard of fracture risk assessment by providing Bone Mineral Density (BMD) which is directly correlated to Body Mass Index (BMI). Recent studies found that the correlation become weaker at BMI >30 kg/sqm while associating a higher mechanical load. The obesity-related fracture risk includes a blunt bone turnover markers status and a proinflammatory environment as IL-6, TNF-a¾³. Common pathogenic pathways involve both the skeleton and the metabolic complications of obesity as growth hormone, insulin-like growth factor-1, angiotensin II and ghrelin. On the contrary, estrogens are fat-derived by aromatase conversion being bone protective as androgens or insulin resistance. Leptin and adiponectin are produced by adipose tissue playing multiple roles including on bone cells. The overlapping factors in obese persons that elevate the fracture risk are the vitamin D deficiency and sarcopenia with increased risk of fall and diabetic bone disease cause by the type 2 diabetes mellitus which is very frequent among obese subjects. Increased cortical porosity as well as alteration of bone matrix quality to the advanced glycation products is correlated to diabetic fracture risk while BMD remain inadequately normal. The correlation between obesity and fall also associates with prior diagnosis of chronic heart disease, severe depression/anxiety, chronic use of anti-depressants or sleeping pills, and sedentary lifestyle. A new map of fractures is drawn since obesity involves a higher risk of ankle (most frequent site in obesity) and humerus fractures and a lower risk of vertebral and hip fractures. The fracture healing is difficult in obese subjects due to inflammation and co-morbidities especially diabetes. Obesity has a rapidly rising prevalence so are the associated conditions; among them fragility fractures at specific sites represents an alarming new issue despite the traditional theories that obesity protects against osteoporosis.