Miracle-dz/UniFAR-FTUs huggingface dataset:
Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction

Continuous methionine restriction (MR) is one of only a few dietary interventions known to dramatically extend mammalian healthspan. For example, continuously methionine-restricted rodents show less age-related pathology and are up to 45% longer-lived than controls. Intriguingly, MR is feasible for humans, andanumberofstudieshavesuggestedthatmethionine-restrictedindividualsmayreceivesimilarhealthspan benefits as rodents. However, long-term adherence to a continuously methionine-restricted diet is likely to be challenging (or even undesirable) for many individuals. To address this, we previously developed an intermittent version of MR (IMR) and demonstrated that it confers nearly identical metabolic health benefits to mice as the continuous intervention, despite having a relatively short interventional period (i.e., only three days per week). We also observed that female mice undergoing IMR show a more pronounced amelioration of diet-induced dysglycemia than continuously methionine-restricted counterparts, while male mice undergoing IMR retain more lean body mass as compared with continuously methionine-restricted controls. Prompted by such findings, we sought to determine other ways in which IMR might compare favorably with continuous MR. While it is known that continuous MR has deleterious effects on bone in mice, including loss of both trabecular and cortical bone, we considered that mice undergoing IMR might retain more bone mass. Here, we report that, as compared with continuous MR, IMR results in a preservation of both trabecular and cortical bone, as well as a dramatic reduction in the accumulation of marrow fat. Consistent with such findings, mechanical testing revealed that the bones of intermittently methionine-restricted mice are significantly stronger than those of mice subjected to the continuous intervention. Finally, static histomorphometric analyses suggest that IMR likely results in more bone mass than that produced by continuous MR, primarily by increasing the number of osteoblasts. Together, our results demonstrate that the more practicable intermittent form of MR not only confers similar metabolic health benefits to the continuous intervention but does so without markedly deleterious effects on either the amount or strength of bone. These data provide further support for the use of IMR in humans.
Forensic Evaluation of the patterns of fatal injuries among pedestrians in road traffic accidents in Hyderabad, Pakistan.

Introduction: Road traffic accidents (RTAs) preventable yet responsible for a large number fatalities among children and adults. It is estimated that RTA causes approximately 1.35 million deaths (27.5 deaths per 100,000 population) through out the world.Objective: To evaluate the patterns of fatal injuries among pedestrians due to road traffic accidents brought in emergency unit of Liaquat University, hospital, Hyderabad.Methodology: This cross-sectional study conducted between Jan 2019 to Dec 2019 and all victims of road traffic accidents brought in the emergency due to fatal injuries belongs to either sex or age-group were included. Data collected includes demographic details; type, site, impact, intensity of inju-ries and different types of vehicles involved in the accidents were recorded from history/ autopsy findings of medico-legal officer. Collected data was entered and analyzed in SPSS ver. 23.Results: Motorcars were more involved (31.0%) in road traffic accidents followed by trucks/loaders (29.0%). Males (87.5%) outnumber female. Head and neck region (26.0%) affected most, while abdomen/pelvis were the least(16.0%) affected. Contusions occurred in predominantly (51.0%) while most (60.5%) pedestrians were found dead when received in the emergen-cy unit. Most common cause of death was head injury induced complica-tions.Conclusion: Injuries to head, neck and facial regions are more common while contusions are the predominant type of injuries occur in the pedestri-ans. Skull bone is most commonly fractured bone among the victimsKeywords: Pattern of injuries, Pedestrians, Road traffic accidents .
Traffic analysis of Internet user behavior and content demand patterns

El estudio del trafico de internet es relevante para poder mejorar la calidad de servicio de los usuarios. Ser capaz de conocer cuales son los servicios mas populares y las horas con mas usuarios activos permite identificar la cantidad de trafico producido y, por lo tanto, disenar una red capaz de soportar la actividad esperada. La implementacion de una red considerando este conocimiento puede reducir el tiempo de espera considerablemente, mejorando la experiencia de los usuarios en la web. Ya existen analisis del trafico de los usuarios y de sus patrones de demanda. Pero, los datos utilizados en estos estudios no han sido renovados, por lo tanto los resultados obtenidos pueden estar obsoletos y se han podido producir cambios importantes. En esta tesis, se estudia la cantidad de trafico entrante y saliente producido por diferentes aplicaciones y se ha hecho una evolucion teniendo en cuenta datos presentes y pasados. Esto nos permitira entender los cambios producidos desde 2007 hasta 2015 y observar las tendencias actuales. Ademas, se han analizado los patrones de demanda de usuarios del inicio de 2016 y se han comparado con resultados previos. La evolucion del trafico demuestra cambios en las preferencias de los usuarios, a pesar de que los patrones de demanda siguen siendo los mismos que en anos anteriores. Los resultados obtenidos en esta tesis confirman las predicciones sobre un aumento del trafico de 'Streaming Media'; se ha comprobado que el trafico de 'Streaming Media' es el trafico total dominante, con Netflix como el mayor contribuidor.
Proteomics Analysis of Pregnancy in Ewes under Heat Stress Conditions and Melatonin Administration

Simple Summary Heat stress is known to cause disruptions to a variety of physiological processes in sheep, including reproduction and ultimately pregnancy, mostly by promoting reactive oxygen species generation and oxidative stress. It has been proposed that the exogenous administration of melatonin, because of its antioxidant and immunomodulatory properties, could help alleviate adverse effects of heat stress. However, the way that melatonin modulates these activities is unclear, especially during pregnancy under heat stress conditions, as well as during lambing. For these reasons, proteomics analysis was used to elucidate the proteins that are regulated by the presence of melatonin. The findings derived from proteomics analysis indicated that melatonin regulates proteins that are involved in cell cycle division, boosted immune response and protective mechanisms affecting both the maternal organism and the embryo(s). Abstract Melatonin is an indoleamine with broad spectrum properties that acts as a regulator of antioxidant and immune response in organisms. In our previous studies, melatonin improved redox status and inflammatory response in pregnant ewes under heat stress conditions. In the present study, using proteomics, the proteins regulated by melatonin during different stages of pregnancy and lambing were assessed. Twenty-two ewes equally divided into two groups, the melatonin (M) (n = 11) and control (C) group (n = 11), participated in the study and were exposed to heat stress during the first months of pregnancy. In the M group, melatonin implants were administered throughout pregnancy, every 40 days, until parturition (a total of four implants per ewe). Blood samples were collected at the beginning of the study simultaneously with the administration of the first melatonin implant (blood samples M1, C1), mating (M2, C2), second implant (M3, C3), fourth implant (M4, C4) and parturition (M5, C5), and MALDI-TOF analysis was performed. The results revealed the existence of 42 extra proteins in samples M2, M3 and M4 and 53 in M5 (sample at parturition) that are linked to melatonin. The biological processes of these proteins refer to boosted immune response, the alleviation of oxidative and endoplasmic reticulum stress, energy metabolism, the protection of the maternal organism and embryo development. This proteomics analysis indicates that melatonin regulates protective mechanisms and controls cell proliferation under exogenous or endogenous stressful stimuli during pregnancy and parturition.
Understanding the relations between soil organic matter fractions and N2O emissions in a long‐term integrated crop–livestock system

The nitrous oxide (N2O) emissions in agricultural systems are influenced by edaphoclimatic conditions, and the availability of soil organic matter (SOM) is a key factor. The objective of this study was to evaluate the accumulation of labile and stable SOM fractions and possible relations with N2O emissions using a multivariate approach in a 24‐year integrated crop–livestock experiment in the Cerrado region. The management systems consisted of: continuous cropping under no tillage (CC‐NT), continuous cropping under annual heavy disc harrow (CC‐CT), an integrated crop–livestock system under no tillage (CLS‐NT) and an adjacent area of native Cerrado as reference. The cumulative N2O emissions were quantified over a period of 146 days throughout the cultivation of sorghum (Sorghum bicolor (L.) Moench). Labile and stable soil carbon (C) fractions and C contents in classes of aggregates (macroaggregates >0.250 mm and microaggregates <0.250 mm) were determined. The cumulative N2O emissions were larger in the CC‐CT system, intermediate in the CC‐NT and CLS‐NT systems, and smaller in the Cerrado. The decomposition of crop residues during the crop succession (first and second crop seasons) and the presence of a grass forage (with grazing and not grazed) in both systems (CLS‐NT and CC‐NT, respectively) explain the differences in N2O fluxes between the land uses. Smaller cumulative N2O emissions were observed in the integrated system (CLS‐NT), which could be attributed to the greatest increase in soil C in its most stable SOM fractions (fulvic acid) and occlusion in microaggregates. This confirms the hypothesis that the accumulation of C in the most stable SOM fractions of the soil, unavailable to the microbiota, results in smaller N2O emissions. Principal component analysis also revealed that aggregation is a key attribute that correlates with soil N2O emissions. Thus, conservation systems such as CLS‐NT had larger average diameter of aggregates and the smallest N2O emissions among the agroecosystems.
Postural status of the spinal column in young rhythmic gymnasts

Numerous studies highlight the beneficial effects of physical activity on children's and adolescents' health in all areas, and it is commonly known that regular sports participation enhances motor skills and has a major impact on physical development and posture. However, asymmetric physical exercises, unique to a certain sport, such as rhythmic gymnastics (RG), can cause aberrant curvatures of the spine, particularly during times of rapid growth and development. The main research objective is to determine the type and prevalence of postural disorders of the spine in sagittal and frontal plane in 48 young female rhythmic gymnasts (RGs), aged 6 to 18, as well as to examine the differences between 25 juvenile and 23 adolescent RGs. Their baseline characteristics (age, body height and mass, and body mass index) were established, as well as their spine curvature status (kyphosis, lordosis, and thoracic and lumbar scoliosis, in °) by means of the SpinalMouse® device. The data were analyzed (descriptive statistics, Kolmogorov-Smirnov test, ANOVA, Chi-square test) using SPSS 21.0. Research results showed that large percentage of RGs had postural disorders in the sagittal (64.6%), and also in the frontal plane (77.1%), noting that postural disorders are more prevalent in juvenile RGs (72% and 76% in the sagittal and the frontal plane, respectively), and flat back is a common spinal posture disorder in RGs. When comparing the sizes of the spinal column curvatures of juvenile and adolescent RGs, statistically significant differences exist only when it comes to kyphosis (p=0.037), and that "in favor" of the older subsample. Such results (presence of lordotic, scoliotic and minor presence of kyphotic posture) are not surprising if we take into account the technical and tactical requirements of RG which belongs to a group of asymmetric sports-RGs have stronger extensors than trunk flexors which leads to absence of kyphotic and an increase of lordotic posture; also, RG is a sport of asymmetric spine loading because of unilateral hip flexibility in various conditions, which explains the large prevalence of scoliotic posture among RGs.
Forensic evidence preservation following an incident of rape: The role of the victim

Background Rape has a high prevalence in South Africa. The collection of credible and valid forensic evidence is a key legal factor that impacts case trial outcomes. Victim behaviour around the time of the rape can impact the collection and the integrity of forensic evidence, and can have a direct effect on case progression and conviction. Despite the importance of victim behaviour, few studies have been done on the role of victims in preserving forensic evidence. This article discusses how common personal hygiene practices undertaken by rape victims after being raped can impact the quality and validity of forensic evidence. This investigation was done with the aim of elucidating the role of victims in preserving forensic evidence post rape. Methods This was a descriptive, retrospective clinical audit of all rape victims managed at Robert Mangaliso Sobukwe Hospital forensic unit in South Africa from 01 January 2020 to 31 March 2022. Results A total of 192 rape cases over the study period were included in this review. The median age of rape victims was 20 years (minimum 2 years; maximum 76 years). The majority (n = 178; 92.7%) of the victims were female. About 44.8% (n = 86) of the victims reported that they had urinated post-rape and prior to forensic examination, 20.8% (n = 40) had changed their clothing, 8.3% (n = 16) had showered, 6.8% (n = 13) had bathed, 4.2% (n = 8) had douched, and only 1.0% (n = 2) had defecated. Only 44 (22.9%) of the victims reported to have ingested alcohol or spiked drinks before the rape. Conclusion These findings suggest that some rape victims engaged in personal hygiene practices that could militate against forensic evidence preservation. This finding, therefore, indicates the need for public awareness about ways to preserve evidence to the greatest extent possible after an incident of rape. Contribution We provide simple guidelines for victims on the preservation of forensic evidence following rape and before detailed forensic medical examination and evidence collection.
Food for Thought Sustaining the world's large marine ecosystems

In this essay, I reviewnearly six decadesof a career inmarine scienceandfisheries considering scientific contributions, successes, failures, andchanges inmyfieldof practice.Mybodyofworkhas been inplankton research to support fisheries assessments, and in ecosystemsprogrammedevelopment and implementation. I describe my early studies on Pacific plankton oceanography in relation to fisheries assessment, and subsequent studies of plankton oceanography and fisheries in relation to coastal ocean fisheries and management. Early in my career, realizing that applications of my published results and those of other fisheries ecologists were generally not included in fish stock assessments, I participated in a national planning group that introduced a system for marine resources monitoring, assessment, and prediction (MARMAP) that included primary productivity, ichthyoplankton, zooplankton, and oceanographic assessments as important components for large-scale fisheries ecology assessment. I joined with European colleagues in ICES to advance fisheries ecology studies in fish stock assessments in the 1970s and 1980s. In 1983, I conceived with Professor Lewis Alexander of the University of Rhode Island a system for assessing and managing marine resources within the spatial domain of ecologically delineated large marine ecosystems (LMEs). On behalf of the National Oceanic and Atmospheric Administration, and in partnership with developing countries, international financial organizations, UN agencies, and NGOs, I am currently contributing scientific and technical advice to a global network of assessment andmanagement projects in 22 LMEswith 110 developing countries and $3.1 billion in financial support. The participating countries are applying a modular framework of natural science and social science indicators for assessing the changing states of LMEs. I conclude the essay with a retrospective viewpoint on my career and changes over half a century of practicing the application of marine science in relation to sustaining the goods and services of the ocean Commons.
Photoelectron spectroscopy of CsK2Sb photocathode at Synchrotron Radiation Facility using vacuum transport system

As accelerators and electron microscopes become more advanced, high-performance photocathodes are required. In particular, Cesium potassium antimonide (CsK2Sb) photocathode is of interest because of its low emittance, excitability in visible light, and high quantum efficiency (QE). The challenge is its high susceptibility to environment that lead to low operating vacuum pressure and short lifetime/low extraction charge. To resolve these issues, it is necessary to understand the molecular structure of the cathode and its degradation mechanism. In this study, we transported CsK2Sb photocathode to a beamline of synchrotron radiation facility using a vacuum transport system for molecular structure analysis. Specifically, the cathode was deposited in an evaporation system at Nagoya University. We transported it to Aichi Synchrotron Radiation Center (Aichi SR) located 15 km away, and analyzed it in the depth direction by X-ray photoelectron spectroscopy (XPS) at BL7U. Based on the results, we quantitatively evaluated the composition ratios and stoichiometry of the cathode elements (Sb, K, Cs). A Cs ex-cess state of surface was observed at the surface, and it is consistent with previous studies. The intended atomic structure of CsK2Sb was formed only at a few nanometres of the surface on the Mo substrate. On the other hand, the CsK2Sb cathode structure on the graphene substrate was preserved further in the depth direction.
Comparison of Immunochromatography test (ICT) with real time polymerase chain reaction (RT – PCR) in detection of HCV.

Objectives: To compare ICT rapid test with RT- PCR. Methodology: This study conducted at Pathological Laboratory Muhammad Medical College Hospital during July-August 2016 with collaboration of The Health Foundation District Sanghar at Goth Haji Khair Muhammad Junejo Kandiari Dist: Sanghar Sindh. 400 subjects from whole the population approximately 674 persons of Goth Haji Khair Mohammad Junejo taulka kandiari district Sanghar were selected in between the age of 10 years to 70 years. The purpose was to treat them if they are HCV positive. All the subjects were first screened for Anti – HCV on ICT method, and then all positive cases were confirmed on RT – PCR. Results: This study conducted during the month of July and August 2016. Total 400 asymptomatic subjects from both male and female were screened by ICT method for Anti – HCV. Out of 400 subjects, 142 (35.5%) were positive. The serum of all 142 subjects positive on ICT, sent to Rawalpindi for HCV qualitative test on RT – PCR, HCV detected in 84 (59.16%) cases and 58 (40.84%) cases were negative. The ratio of variation (ICT: RT-PCR) was 1.44. Conclusion: Rapid ICT method is less sensitive compare to RT – PCR. There is variation of results in between two methods. All positive cases on ICT must be confirmed on RT – PCR. There is false positivity in ICT method. Key word: ICT (Immunochromatography test) RT – PCR (Real time polymerase chain reaction) RIA (Radio immunoassay) ELISA (Enzyme linked immunosorbent assay) EIA (Enzyme immunoassay).
The Joint Forces of How to Live: Does Intellectual Capital Matter between Innovation and Financial Vulnerability?

Using a hand-collected sample of non-financial firms listed on the Pakistan Stock Exchange (PSX) over the period of 2011–2021, we examine the joint effect of intellectual capital and innovation on the financial vulnerability of a firm, which is an important risk factor that a firm may face in its operation. We first use the static fixed-effect panel model as our baseline regression model and find that the level of intellectual capital of a firm strengthens the positive effect of the adoption of product and market innovation on reducing the financial vulnerability of the firm. We also conduct additional analyses using alternative measures of financial vulnerability, as well as various regression models, and confirm that the results are robust under different scenarios. Overall, the results highlight the positive role of the intellectual capital, as well as the joint effect of intellectual capital and innovation, in mitigating the financial vulnerability faced by a firm and thus have academic and practical implications to academic researchers and practitioners.
Determinants of Firm Value and Its Implications on Stock Return of Banking Companies in Indonesia

This study aims to examine the effect of good corporate governance, macroeconomics, profitability and firm size on firm value which has implications for stock returns. Quantitative methods with panel data regression. The sample is 15 banking companies for the 2015-2021 period. The results show that 1) good corporate governance has no direct effect on stock returns but has a significant negative effect indirectly through firm value, 2) macroeconomics directly has a significant positive effect on stock returns but indirectly through firm value has no significant effect, 3 ) profitability either directly or indirectly through firm value has no significant effect on stock returns, 4) firm size either directly or indirectly through firm value has a significant positive effect on stock returns, 5) together good corporate governance, macro economy, profitability, and firm size have a significant positive effect on firm value, 6) together good corporate governance, macroeconomics, profitability, firm size and firm value have a significant positive effect on stock returns.
Emotion and financial markets

Psychologists and economists hold vastly different views about human behavior. Psychologists contend that economists' models bear little relation to actual behavior. This view is supported by a large body of psychological research that shows that emotional state can significantly affect decision making. ; Economists, on the other hand, argue that psychological studies have no theoretical basis and offer little empirical evidence about people's decision-making processes. The reigning financial economics paradigm-the efficient market hypothesis (EMH)-assumes that individuals make rational investment decisions using the rules of probability and statistics. A newer branch of financial economics called behavioral finance applies lessons from psychology to financial decision making, but most of these studies have focused on cognitive biases rather than emotion. ; The authors of this article argue that emotion has important, and possibly beneficial, influences on financial behavior. After defining the term emotion and describing how emotions can be categorized, the authors consider how emotions influence human behavior. The discussion focuses particularly on three aspects of emotion and financial decision making: emotional disposition and stock market pricing, the feeling of regret, and investors' emotional response to information. ; No new financial economics paradigm that incorporates behavioral influences and better models actual behavior has yet emerged to replace the EMH. Yet the authors believe that emotional behavior's influence on financial decision making should be taken into account in future research.