Miracle-dz/UniFAR-FTUs huggingface dataset:
Full‐zirconia single‐tooth molar implant‐supported restorations with angulated screw channel abutments: A 1‐year prospective case series study

Abstract Background Implant‐supported restorations in the posterior region are subjected to various complications that could be prevented by changing either the design or the material. Purpose The aim of this prospective case series study was to evaluate full‐zirconia implant‐supported restorations with angulated screw channel abutments in the molar region of the maxilla and mandible and their effect on hard and soft peri‐implant tissues, during a 1‐year follow‐up period. Materials and Methods Thirty consecutive patients with a single missing molar, sufficient bone height, and implant site free of infection were included. Each patient was to receive a parallel‐walled implant with conical connection according to a two‐staged surgical protocol. After 3 months, a full‐contour screw‐retained zirconia restoration with angulated screw channel abutment was provided. Clinical and radiographic examinations were performed 1 and 12 months after placement of the restoration. Patients' satisfaction was scored prior to treatment and after 12 months with the restoration in function. Primary outcome measure was success of the restoration. Results All patients could be evaluated after 12 months. Success of the restorations was 100%. From loading to the 12‐month follow‐up, the mean marginal bone loss was 0.16 mm (SD: 0.26). Mean scores for plaque, calculus, peri‐implant mucosa, bleeding, and pocket probing depth were low, depicting healthy peri‐implant conditions. Patients' satisfaction was high and had improved after treatment. Conclusion Full‐contour zirconia implant‐supported restorations with angulated screw channel abutments in the molar region have an excellent clinical performance after 1 year of function.
High-affinity binding of plasminogen-activator inhibitor 1 complexes to LDL receptor–related protein 1 requires lysines 80, 88, and 207

It is well-established that complexes of plasminogen-activator inhibitor 1 (PAI-1) with its target enzymes bind tightly to low-density lipoprotein (LDL) receptor-related protein 1 (LRP1), but the molecular details of this interaction are not well-defined. Furthermore, considerable controversy exists in the literature regarding the nature of the interaction of free PAI-1 with LRP1. In this study, we examined the binding of free PAI-1 and complexes of PAI-1 with low-molecular-weight urokinase-type plasminogen activator to LRP1. Our results confirmed that uPA:PAI-1 complexes bind LRP1 with ∼100-fold increased affinity over PAI-1 alone. Chemical modification of PAI-1 confirmed an essential requirement of lysine residues in PAI-1 for the interactions of both PAI-1 and uPA:PAI-1 complexes with LRP1. Results of surface plasmon resonance measurements supported a bivalent binding model in which multiple sites on PAI-1 and uPA:PAI-1 complexes interact with complementary sites on LRP1. An ionic-strength dependence of binding suggested the critical involvement of two charged residues for the interaction of PAI-1 with LRP1 and three charged residues for the interaction of uPA:PAI-1 complexes with LRP1. An enhanced affinity resulting from the interaction of three regions of the uPA:PAI-1 complex with LDLa repeats on LRP1 provided an explanation for the increased affinity of uPA:PAI-1 complexes for LRP1. Mutational analysis revealed an overlap between LRP1 binding and binding of a small-molecule inhibitor of PAI-1, CDE-096, confirming an important role for Lys-207 in the interaction of PAI-1 with LRP1 and of the orientations of Lys-207, -88, and -80 for the interaction of uPA:PAI-1 complexes with LRP1.
Does ‘Dual Trigger’ Increase Oocyte Maturation Rate?

Abstract The aim of this study was to evaluate the oocyte maturation rate when GnRH-a and hCG (dual trigger) are co-administered, compared to the standard hCG trigger within the same patient. Included in the study were GnRH antagonist ICSI cycles performed in 137 patients who had a standard hCG trigger cycle and a dual trigger cycle between 1/1/2013 and 31/12/2017. The mean patient age (35.9 ± 5.6 and 35.2 ± 5.9; <0.001), FSH dose (4140 ± 2065 and 3585 ± 1858; <0.01), number of retrieved oocytes (10.3 ± 6.2 and 8.9 ± 6.1; 0.011) were higher in the dual trigger group compared to the hCG trigger group, oocyte maturation rate was identical. Maturation rate following dual trigger was significantly higher among 34 patients who had a maturation rate of <70% following hCG triggering and among 16 patients with a maturation rate <50% rate following hCG trigger (54% vs. 74%, p < .001 and 44% vs. 73%, p = .006; respectively). In conclusion, co-administration of GnRH agonist and hCG for final oocyte maturation substantially increased the oocyte maturation rate in patients with low oocyte maturation rate in their hCG triggered cycle, but not in an unselected population of patients. IMPACT STATEMENT What is already known on this subject? The co-administration of GnRH agonist and hCG for final oocyte maturation prior to oocyte retrieval may improve IVF outcome in patients with a high proportion of immature oocytes. The few studies on dual trigger in patients with a high proportion of immature oocytes or in normal responders have shown conflicting results. What do the results of this study add? We found that co-administration of GnRH agonist and hCG for final oocyte maturation substantially increased the oocyte maturation rate in patients with low oocyte maturation rate in their hCG triggered cycle, but not in an unselected population of patients. What are the implications of these findings for clinical practice and/or further research? The results of this study implicate that in selected population with low oocyte maturation rate, there is an advantage in using dual trigger. However, larger prospective trials are warranted to better assess oocyte response in dual trigger.
Effect of treatment period with LC478, a disubstituted adamantayl derivative, on P-glycoprotein inhibition: its application to increase docetaxel absorption in rats

Abstract 1. Treatment periods of P-glycoprotein (P-gp) inhibitors have revealed different efficacies. We have previously reported dose-dependent inhibition of P-gp in single-treatment with LC478. However, whether repeated treatment with LC478 can inhibit P-gp even at its ineffective single-treatment dose remains unknown. 2. Therefore, the purpose of this study was to assess the effect of repeated treatment (i.e., 7-day treatment) with LC478 on P-gp known to affect docetaxel bioavailability in rats. Effects of LC478 on P-gp mediated efflux and expression in MDCK-MDR1 cells, P-gp ATPase activity, and binding site with P-gp were evaluated. 3. The 7-day treatment with LC478 increased docetaxel absorption via intestinal P-gp inhibition in rats. Intestinal concentrations of LC478 were 8.31—10.3 μM in rats after 7-day treatment of LC478. These concentrations were close to 10 μM that reduced P-gp mediated docetaxel efflux and P-gp expression in MDCK-MDR1 cells. Considering that intestinal LC478 concentrations after 1-day treatment were 2.68—4.19 μM, higher LC478 concentrations after 7-day treatment might have driven P-gp inhibition and increased docetaxel absorption. LC478 might competitively inhibit P-gp considering its stimulated ATPase activity and its binding site with nucleotide binding domain of P-gp. 4. Therefore, repeated treatment with LC478 can determine its feasibility for P-gp inhibition and changing docetaxel bioavailability.
Microglia attenuate the kainic acid‐induced death of hippocampal neurons in slice cultures

Status epilepticus‐induced hippocampal neuronal death, astrogliosis, and the activation of microglia are common pathological changes in mesial temporal lobe epilepsy (mTLE) with resistance to antiepileptic drugs. Neuronal death in mTLE gradually progresses and is involved in the aggravation of epilepsy and the impairment of hippocampus‐dependent memory. Thus, clarifying the cellular mechanisms by which neurons are protected in mTLE will significantly contribute to the treatment of epilepsy. Here, mainly using hippocampal slice cultures with or without the pharmacological depletion of microglia, we directly examined whether microglia, the resident immune cells of the brain that can act either neurotoxically or in a neuroprotective manner, accelerate or attenuate kainic acid (KA)‐induced neuronal death in vitro.
Triptan and ergotamine overdoses in the United States

Objective To examine the clinical outcomes of intentional overdoses involving triptans and ergotamines with a retrospective review of the National Poison Data System (NPDS). Methods This was a 5-year retrospective cross-sectional study (2014–2018) using the NPDS. Demographics, exposure characteristics, and outcomes were described. Univariate logistic regression was used to estimate the odds ratio (OR) for major effect or death. A multivariable logistic regression model with inclusion criteria of p < 0.1 in univariate analysis was implemented with backwards selection. Results In this population (n = 1,489), multiple exposure was most common (n = 1,145). The mean age was 31.2 years and 1,197 (80.4%) participants were female. Major effects from a single exposure were seen in <1% with no recorded deaths. Triptan ingestion (n = 328) resulted in hypertension (14%), tachycardia (10.7%), drowsiness (11%), nausea (6.4%), vomiting (4.6%), vertigo (4%), chest pain (3.7%), and diaphoresis (2.4%). Ergotamine ingestion (n = 16) resulted in abdominal pain (16%), vomiting (12.5%), numbness (12.5%), nausea (6.3%), diarrhea (6.3%), and vertigo (6.3%). No clinical effect was seen in 90 (26.2%). No cases met Hunter criteria for serotonin syndrome. There is risk of major event or death due to age (OR 1.02; 95% confidence interval [CI] 1.01–1.04; p = 0.004), multiple product exposure (OR 9.50; 95% CI 2.29–39.48; p = 0.002), and concomitant overdose with benzodiazepines (OR 1.71; 95% CI 1.05–2.78; p = 0.032) or tricyclic antidepressants (OR 3.16; 95% CI 1.88–5.31; p < 0.001). Conclusion The risk of major effect or death was low and predicted by age, multiple product exposure, and concomitant benzodiazepine or tricyclic antidepressant. The triptan toxidrome consists of hypertension, tachycardia, and drowsiness. The toxic effects of ergotamine are acute gastrointestinal syndrome with vertigo and numbness. No cases of serotonin syndrome were seen.
Single‐agent daratumumab in patients with relapsed and refractory multiple myeloma requiring dialysis: results of a Spanish retrospective, multicentre study

Between 20–40% of patients with multiple myeloma (MM) present with renal impairment (RI) at diagnosis (Korbet & Schwartz, 2006; Kastritis et al., 2007) and up to 10% of them require dialysis (Dimopoulos et al., 2010). Prognosis in these patients remains significantly worse when compared with patients with normal renal function (Haynes et al., 2010). Daratumumab is an anti-CD38 IgG kappa human monoclonal antibody that has demonstrated superior clinical benefit across lines of therapy, either as monotherapy or when combined with standard-of-care regimens for the treatment of patients with relapsed and refractory MM (RRMM) (Usmani et al., 2016; van de Donk et al., 2016). However, data of daratumumab in patients with RRMM and dialysis-dependant renal failure are lacking. We report the efficacy and safety results from a retrospective Spanish study of daratumumab in patients with RRMM and end-stage RI requiring dialysis.
A Comparison of Risk Factors for Intimate Partner Violence–Related Injury Across Two National Surveys on Violence Against Women

This study compares risk factors for intimate partner violence–related injury across two national data sources on violence against women, the Canadian Violence Against Women Survey and the National Violence Against Women Survey in the United States. After equating the data sets as much as possible on the types of violence experienced and risk factors, the authors determined which risk factors in each data source predicted injury and compared the magnitudes of associations between risk factors and injury across the data sets. The article presents results on bivariate and multivariate findings, model fit across the data sets, and statistical comparisons of findings across the data sets. Obtaining convergent findings across data sources on risk factors for injury will allow public health practitioners to intervene more effectively with women at risk for experiencing violence-related injuries perpetrated by spouses.
Seasonal Characteristics of Sulfate and Nitrate in Size-segregated Particles in Ammonia-poor and -rich Atmospheres in Chengdu, Southwest China

ABSTRACT In order to determine the seasonal characteristics of water-soluble inorganic ions (WSIIs) in aerosols in urban atmospheres, size-segregated particulate matter (PM) samples were collected over a one-year period from February 2012 to January 2013 in a typical urban location, Chengdu in Southwest China, using an Andersen cascade impactor sampler. The PM mass concentrations, particularly the fine fraction, peaked during winter, and the WSIIs were more enriched in the fine fraction (21.7%) than the coarse fraction (9.2%). The sums of the equivalent ratios of cations (Na+, NH4+, K+, Mg2+, and Ca2+) to anions (SO42–, NO3–, Cl–, and F–) indicated that the fine particles (0.86) were more acidic than the coarse ones (1.60). The average NH4+/SO42– molar ratio (A/S) in the fine fraction (1.79) was much higher during winter than the other three seasons (< 1.5), implying a generally NH3-poor atmosphere in Chengdu; hence, the NO3– in the fine particles was principally formed through homogeneous reactions involving ammonia and nitric acid during winter, whereas it was heterogeneously formed during the other three seasons. Significant positive correlations were observed between the A/S and NO3– molar concentrations during spring and winter; therefore, the formation of particle-phase NO3– may be accelerated by increased A/S in both NH3-poor and -rich atmospheres. Moreover, the A/S and NO3–/SO42– molar ratios displayed negative and positive correlations during spring and winter, respectively, suggesting that the variation in atmospheric NH4+ (or NH3) during winter affected the formation of NO3– more strongly than that of SO42–, whereas more SO42– than NO3– was formed in the NH3-poor atmosphere during spring, when most of the NO3– in the aerosols would be expected to form via heterogeneous reactions.
PERFORMANCE OF HYBRID CATFISH SUBJECTED TO DIFFERENT PROTEIN LEVELS

In this study, we investigated the performance of hybrid catfish (Pseudoplatystoma reticulatum x Leiarius marmoratus) fed with feeds containing 32% or 40% crude protein (CP). We analyzed the performance, yield in whole gutted fish, fillet yield and visceral fat index. The experimental units comprised 108 fish with average initial weights of 272.12 ± 74.71 g (32% CP) and 231.97 ± 87.70 g (40% CP). The experimental period was 182 days. Final weight, body height, body width, yield of whole gutted fish and visceral fat content differed (P<0.05) between treatments, with respective values of 1,016.63 g, 7.17 cm, 6.88 cm, 86.06% and 3.28% for the lower protein level; and 1,152.22 g, 7.67 cm, 7.27 cm, 84.44% and 4.81% for the higher protein level. The treatment with 40% CP promotes better performance of hybrid catfish. However, this treatment reduces the yield of whole gutted fish and increases the visceral fat index.
Antecedents of Entrepreneurial Propensity: Findings from Singapore, Hong Kong and Taiwan

The existing literature identifies a number of antecedent factors that positively influence the propensity of individuals to become entrepreneurs. Key among these is self-efficacy, knowledge of other entrepreneurs and the perception of opportunities. At the same time, current research shows that fear of failure is a major deterrent factor for entrepreneurs taking the entrepreneurial plunge. Using Shane's (2003) individual-opportunity nexus framework as an overarching theory, our study examines how these antecedents and deterrent factors influence the individual's propensity to start a new business in the three East Asian economies of Singapore, Hong Kong, and Taiwan. We also test for possible differences in the variables effects on an individual's propensity to start a new business out of necessity versus the perception of opportunity. Importantly, our findings highlight significant location differences among the variables for opportunity-driven start-ups, while no significant differences were found for necessity-driven start-ups. Finally, we discuss the relevant policy implications from our findings.
Examining the Young Consumer Purchase Intention of Eco-Friendly Home: Insight from Indonesian

The main target of eco-friendly homes is reducing and eliminating its negative environmental impact by improving the design and construction. Among young consumers, ecofriendly homes are the best solution to preventing continuous environmental damage. However, young consumers have many background factors that come into play when deciding to purchase an eco-friendly home that are internal and external. The empirical findings from the previous research demonstrated that the environmental knowledge and culture values affected the consumer in terms of their green purchase behavioural intention as in the extended Theory of Planned Behaviour (TPB) determinant. The objective of this study is to investigate whether the environmental knowledge and cultural values of the young buyers’ affects their purchase intention when it comes to an ecofriendly home. Using a quantitative approach and survey design by distributing a questionnaire, the respondents for this study were made up of 200 prospective young buyers within the eco-friendly home development concept in Malang and Surabaya. This study found that environmental knowledge positively influenced young consumer purchase intention as well as the culture value variable. Overall, the results provide empirical evidence on the importance of environmental knowledge and the culture value for young consumers when related to their eco-friendly home purchase intention. Therefore, the stakeholders of eco-friendly home development should more aware of and seek to improve young consumer knowledge and the culture value when focused toward the ecofriendly home concept in order to succeed at sustainable development. Keywords—young consumer, purchase intention, eco-friendly home, environmental knowledge, culture
Social Glasses: Simulating Interactive Gaze for Visually Impaired People in Face-to-Face Communication

ABSTRACT Eye contact is crucial in social interactions, linking with sincerity and friendliness. However, blind people cannot see and make eye contact when they communicate with sighted people. It influences the involvement of blind people in blind-sighted conversations. Based on this context, we implemented Social glasses with an eye-tracking system, aiming to improve the communication quality between blind and sighted people in face-to-face conversations. Social glasses attempts to simulate the appropriate gaze for blind people, especially establishing the “eye contact” in blind-sighted conversations. To evaluate the impact of the interactive gaze displayed on the Social glasses, we performed dyadic-conversation tests under four experimental conditions (No Gaze, Constant Gaze, Random Gaze, and Interactive Gaze) for 40 participants. Quantitative results showed that the Interactive gaze has a positive impact on improving the communication quality between blind and sighted people, which were consistent with a qualitative analysis of the participants’ comments.
Master thesis in Health Psychology

Background: Videogames are a popular pastime for adolescents. Above all online games, especially those called Massively Multiplayer Online Games [MMOGs], are highly popular among adolescents. This type of game is characterized by high social interaction of players acting together in a virtual world. Research indicates that this type of game is strongly linked to problematic gaming and negative effects of gaming. Objective: The objective of this longitudinal study is to figure out the role the Gaming Type [GT] plays in developing problematic gaming behavior [PGB] and negative outcomes of gaming. Therefor, cognitive behavioral model was taken as theoretical basis. Method: Dutch adolescents aged 13 to 22 were asked to fill in an online questionnaire at baseline (T1) and 6-month follow-up (T2). They were approached via their schools located in western areas of the Netherlands. Most important components measured were GT, POSI (preference for online social interaction) and loneliness as predictors at baseline and PGB and negative outcomes as outcome variables at the 6-month follow-up. Moderation-analysis was performed with GT as dichotomous variable (MMOG vs. non-MMOG) to investigate whether GT has impact on the relationship between the two predictor variables (POSI and loneliness) at baseline and PGB and negative outcomes at 6month follow-up. Results: Major finding of this study is that for the two GTs different variables seem to predict negative consequences of gaming. For the non-MMOG group results clearly indicate that loneliness is a risk factor for gamers to develop PGB and negative outcomes of gaming. This is indicated by moderation-analysis showing that non-MMOG gamers suffering from loneliness do score high on PGB and negative outcomes. Path-analysis does confirm these results. For the MMOG group results suggest that POSI may be a risk factor; but results are not clear in this case. However, this study gives important insights in the mechanisms of developing PGB and negative outcomes of gaming due to the GT played.
Assessing the complexity of medicine regimens - A pilot study

Complexity of medication regimens may adversely affect adherence and treatment outcome. The aim of this study was to assess the complexity of medication regimens. In this retrospective study, complexity of the medication regimens for outpatients was assessed using the medication regimen complexity index (MRCI). The correlation between medication complexity and the parameters of age, gender, underlying disorder and the number of medications were determined. Significant parameters impact on medication complexity were found to be age and number of medications. Therefore older patients, as well as patients taking several medications, should be monitored for compliance and adherence must be emphasized. Key words: Medication, complexity, adherence, treatment, regimens.
A Study Of Anaemia In Pregnancy In Block Ganderbal

A cross sectional survey of Block Ganderbal to examine 544 pregnant and 100 non-pregnant women was conducted from 12 randomly selected villages. Overall 43.01% of pregnant women. Average hemoglobin level among pregnant women was 10.19 +/- 1.5 gms % with a range of 6.5 gms to 13.2 gms%. Incidence of anemia was seen to increase with increase in parity. Haemoglobin level was seen to decline with the advance of gestational age and higher hemoglobin values were observed among women taking iron and folic acid supplements than those not consuming the same.