Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance Improvement Through Motivation: Commitment Parallel Mediation Model

<p><strong><em>Purpose</em></strong><em> </em><em>The study describes a parallel mediation model of improving performance through motivation with the mediation of commitment (affective, normative, and continuation). This provides an overall picture of how three commitment dimensions and their variations mediate the relationship between motivation and performance. <strong>Methodology</strong></em><strong><em> </em></strong><em>A sample of 105 respondents from online motorcycle taxi drivers in Jakarta Indonesia was taken using a convenience sampling technique. The method of testing the hypothesis is through the macro process model no 4 with SPSS and Process v3.5. </em><em> <strong>Findings</strong> </em><em>The results found that total commitment (all three combined/ unidimensional) was shown to mediate the relationship between extrinsic and intrinsic motivation for performance. Meanwhile, when the commitment is multidimensional, only affective commitment mediates the relationship between extrinsic and intrinsic motivation to performance. </em><em>. <strong>Suggestion</strong> </em><em>This finding has implications for companies to maintain employee commitment, especially affective commitment. </em></p>
Symptom Structure of Depression in Older Adults on the Qinghai–Tibet Plateau: A Network Analysis

Previous studies have confirmed that depression among residents in high-altitude areas is more severe, and that depression may be more persistent and disabling in older adults. This study aims to identify the symptom structure of depression among older adults on the Qinghai–Tibet Plateau (the highest plateau in the world) from a network perspective. This cross-sectional study enrolled 507 older adults (ages 60–80 years old) from the Yushu Prefecture, which is on the Qinghai–Tibet Plateau, China. Depressive symptoms were self-reported using the shortened Center for Epidemiological Studies–Depression Scale (CES-D-10). Then, a Gaussian graphical model (GGM) of depression was developed. Poor sleep, fear, and hopelessness about the future exhibited high centrality in the network. The strongest edge connections emerged between unhappiness and hopelessness about the future, followed by hopelessness about the future and fear; hopelessness about the future and poor sleep; fear and unhappiness; and then poor sleep and unhappiness in the network. The findings of this current study add to the small body of literature on the network structure and complex relationships between depressive symptoms in older adults in high-altitude areas.
Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein

The protein lysine deacylases of the NAD+-dependent Sirtuin family contribute to metabolic regulation, stress responses, and aging processes, and the human Sirtuin isoforms, Sirt1-7, are considered drug targets for aging-related diseases. The nuclear isoform Sirt1 deacetylates histones and transcription factors to regulate, e.g., metabolic adaptations and circadian mechanisms, and it is used as a therapeutic target for Huntington’s disease and psoriasis. Sirt1 is regulated through a multitude of mechanisms, including the interaction with regulatory proteins such as the inhibitors Tat and Dbc1 or the activator AROS. Here, we describe a molecular characterization of AROS and how it regulates Sirt1. We find that AROS is a partly intrinsically disordered protein (IDP) that inhibits rather than activates Sirt1. A biochemical characterization of the interaction including binding and stability assays, NMR spectroscopy, mass spectrometry, and a crystal structure of Sirtuin/AROS peptide complex reveal that AROS acts as a competitive inhibitor, through binding to the Sirt1 substrate peptide site. Our results provide molecular insights in the physiological regulation of Sirt1 by a regulator protein and suggest the peptide site as an opportunity for Sirt1-targeted drug development.
Crude Extracts of Codiaeum Variegatum Stem Exhibit Potent Antioxidant and Anti-inflammatory Activities in Vitro

Background and objectives: Codiaeum variegatum ( C. variegatum ), which is commonly known as garden croton, is a medicinal plant used for the treatment of amoebiasis in Cameroon and some Asian countries. The present study aims to evaluate the antioxidant and anti-inflammatory activities of the stem crude extracts of C. variegatum . Methods: Aqueous, hydroethanolic 70/30 (v/v) and ethanolic extracts were tested for antioxidant activity using DPPH radical scavenging, ferric iron-reducing antioxidant power (FRAP), and lipid peroxidation inhibitory assays. The anti-inflammatory activity was determined based on the inhibition of nitric oxide production on isolated mouse macrophages activated by Saccharomyces cerevisiae. Furthermore, the inhibitory effect of these extracts on 5-lipoxygenase activity and bovine serum albumin (BSA) denaturation was determined, and the activation of two lysosomal enzymes involved in phagocytosis was performed. The phytochemical screening of the plant extracts was performed using standard methods. Results: The results revealed that the ethanolic extract (EE) exhibited the highest antioxidant activity, in terms of DPPH-free radical scavenging activity, FRAP, and its potential to inhibit lipid peroxidation (IC 50 = 77.04 µg extract/mol of DPPH; EC 50 = 543.6 µg/mL and IC 50 = 21.52 µg/mL, respectively). However, this activity remained significantly lower than that of ascorbic acid ( p < 0,05). Furthermore, the hydroethanolic extract (HE) had the highest anti-inflammatory activity on isolated mouse macrophages, in terms of inhibitory activity on NO production, BSA denaturation, and 5-lipoxygenase activity (IC 50 = 8.80 µg/mL, IC 50 = 205.9 µg/mL, IC 50 = 0.08 µg/mL, respectively). However, there was no significant difference in the inhibitory activity of baicalin. Moreover, the activity of acid phosphatase and alkaline phosphatase increased in the presence of the HE (EC 50 = 10.03 µg/mL and EC 50 = 0.274 µg/mL, respectively). The phytochemical analysis of these extracts indicates the presence of phenolic compounds, and these may be responsible for the observed activities. Conclusions: Overall, these results demonstrate that the hydroethanolic and ethanolic stem extracts of C. variegatum have good antioxidant and anti-inflammatory potential.
A small-scale dynamo in feedback-dominated galaxies - II. The saturation phase and the final magnetic configuration

Magnetic fields in galaxies are believed to be the result of dynamo amplification of initially weak seed fields, reaching equipartition strength inside the interstellar medium. The small-scale dynamo appears to be a viable mechanism to explain observations of strong magnetic fields in present-day and high-redshift galaxies, considering the extreme weakness of seed fields predicted by battery mechanisms or primordial fields. Performing high-resolution adaptive mesh magneto-hydrodynamic simulations of a small mass, isolated cooling halo with an initial magnetic seed field strength well below equipartition, we follow the small-scale dynamo amplification from supernova-induced turbulence up to saturation of the field. We find that saturation occurs when the average magnetic pressure reaches only 3 % to 5 % of the turbulent pressure. The magnetic energy growth transitions from exponential to linear, and finally comes to halt. The saturation level increases slightly with grid resolution. These results are in good agreement with theoretical predictions for magnetic Prandtl numbers of order $\mathrm{Pr_M} \sim 1$ and turbulent Mach numbers of order $\mathrm{M} \sim 10$. When we suppress supernova feedback after our simulation has reached saturation, we find that turbulence decays and that the gas falls back onto a thin disk with the magnetic field in local equipartition. We propose a scenario in which galactic magnetic fields are amplified from weak seed fields in the early stages of the Universe to sub-equipartition fields, owing to the turbulent environment of feedback-dominated galaxies at high redshift, and are evolved further in a later stage up to equipartition, as galaxies transformed into more quiescent, large spiral disks.
The radial abundance gradient of oxygen towards the Galactic anti-centre

We present deep optical spectroscopy of eight HII regions located in the anticentre of the Milky Way. The spectra were obtained at the 10.4m GTC and 8.2m VLT. We determined Te([NII]) for all objects and Te([OIII]) for six of them. We also included in our analysis an additional sample of 13 inner-disc Galactic Hii regions from the literature that have excellent T_e determinations. We adopted the same methodology and atomic dataset to determine the physical conditions and ionic abundances for both samples. We also detected the CII and OII optical recombination lines in Sh 2-100, which enables determination of the abundance discrepancy factor for this object. We found that the slopes of the radial oxygen gradients defined by the HII regions from R_25 (= 11.5 kpc) to 17 kpc and those within R_25 are similar within the uncertainties, indicating the absence of flattening in the radial oxygen gradient in the outer Milky Way. In general, we found that the scatter of the O/H ratios of Hii regions is not substantially larger than the observational uncertainties. The largest possible local inhomogeneities of the oxygen abundances are of the order of 0.1 dex. We also found positive radial gradients in Te([O III]) and Te([N II]) across the Galactic disc. The shapes of these temperature gradients are similar and also consistent with the absence of flattening of the metallicity distribution in the outer Galactic disc.
Purchase Intention of Batam People Against Foreign Sellers in the Marketplace

This research is motivated by increased product purchases from overseas sellers in Batam City. This increase in sales indicates an increase in purchase intention on overseas seller marketplace products. This study aimed to analyze the effect of trust, perceived risk, price, perceived benefit, product quality, and E-WOM on purchase intention. This study uses quantitatives methods and data collected by questionnaire technique. Respondent's study included as many as 300 people living in Batam City on the condition that they have shopped at foreign sellers in marketplace. Six hypotheses were formulated and tested using T-test analysis. The results showed that perceived risk, perceived benefit, price, and E-WOM significant positively affected purchase intention. Meanwhile, trust and product quality had no significant positive effect on purchase intention. Therefore, Batam City MSMEs must be more innovative in making products and have a broader range of marketing methods to increase MSMEs of local products rather than imported goods from abroad.
Work-Family Conflict Affect Employee Performance During The Covid-19 In Jakarta

The pandemic has the consequence of increasing workers working from home or WFH. A WFH as a new working style creates problems for workers because they have to concentrate on separating work and family interests. Workers will focus more on work in the office so that distractions from family interests are minor. This study aims to determine the effect of work-family conflict during WFH during the COVID-19 pandemic in Jakarta. The quantitative methods were conducted by distributing questionnaires to married employees who have children, have or are currently experiencing WFH (work from home), and work locations in Jakarta. The technique of processing data using the SEM (Structural Equation Modeling) method using the Smart PLS 3.0 tool. The sample was 114 respondents with a significant level used of 5%. Work-Family conflict is divided into Work Interference, Family and Family Interference Work. The results of this study indicate that the influence of Work Interference Family and Family Interference Work negatively affects employee performance. A statistical test of all hypotheses supports it. WFH is an increasingly developing type of working during a pandemic, which has led to Work-Family conflicts, both in terms of work (WIF) and family (FIW) regarding their performance. From these results, it is interesting to investigate whether the same thing will happen if the type of work is work from the office (WFO).
Giant nonlinear damping in nanoscale ferromagnets

Nonlinear magnon scattering redefines how nanomagnets respond to spin currents. Magnetic damping is a key metric for emerging technologies based on magnetic nanoparticles, such as spin torque memory and high-resolution biomagnetic imaging. Despite its importance, understanding of magnetic dissipation in nanoscale ferromagnets remains elusive, and the damping is often treated as a phenomenological constant. Here, we report the discovery of a giant frequency-dependent nonlinear damping that strongly alters the response of a nanoscale ferromagnet to spin torque and microwave magnetic field. This damping mechanism originates from three-magnon scattering that is strongly enhanced by geometric confinement of magnons in the nanomagnet. We show that the giant nonlinear damping can invert the effect of spin torque on a nanomagnet, leading to an unexpected current-induced enhancement of damping by an antidamping torque. Our work advances the understanding of magnetic dynamics in nanoscale ferromagnets and spin torque devices.
Evidence for the Third Stellar Population in the Milky Way’s Disk

The Milky Way is a unique laboratory in which stellar properties can be measured and analyzed in detail. In particular, stars in the older populations encode information on the mechanisms that led to the formation of our Galaxy. In this article, we analyze the kinematics, spatial distribution, and chemistry of a large number of stars in the solar neighborhood, where all of the main Galactic components are well represented. We find that the thick disk comprises two distinct and overlapping stellar populations with different kinematic properties and chemical compositions. The metal-weak thick disk (MWTD) contains two-times less metal content than the canonical thick disk, and exhibits enrichment of light elements typical of the oldest stellar populations of the Galaxy. The rotational velocity of the MWTD around the Galactic center is ∼150 km s−1, corresponding to a rotational lag of 30 km s−1 relative to the canonical thick disk (∼180 km s−1), with a velocity dispersion of 60 km s−1. This stellar population likely originated from the merger of a dwarf galaxy during the early phases of our Galaxy’s assembly, or it is a precursor disk, formed in the inner Galaxy and brought into the solar neighborhood by bar instability or spiral-arm formation mechanisms.
Public Health Measures to Address the Impact of Climate Change on Population Health—Proceedings from a Stakeholder Workshop

Background: The World Health Organization identified climate change as the 21st century’s biggest health threat. This study aimed to identify the current knowledge base, evidence gaps, and implications for climate action and health policymaking to address the health impact of climate change, including in the most underserved groups. Methods: The Horizon-funded project ENBEL (‘Enhancing Belmont Research Action to support EU policy making on climate change and health’) organised a workshop at the 2021-European Public Health conference. Following presentations of mitigation and adaptation strategies, seven international researchers and public health experts participated in a panel discussion linking climate change and health. Two researchers transcribed and thematically analysed the panel discussion recording. Results: Four themes were identified: (1) ‘Evidence is key’ in leading the climate debate, (2) the need for ‘messaging about health for policymaking and behaviour change’ including health co-benefits of climate action, (3) existing ‘inequalities between and within countries’, and (4) ‘insufficient resources and funding’ to implement national health adaptation plans and facilitate evidence generation and climate action, particularly in vulnerable populations. Conclusion: More capacity is needed to monitor health effects and inequities, evaluate adaptation and mitigation interventions, address current under-representations of low- or middle-income countries, and translate research into effective policymaking.
Emotion-Focused Mobile App for Promoting Self-Compassion, Self-Protection, and Self-Criticism

The COVID-19 pandemic has changed our daily lives and restricted access to traditional psychological interventions. Hence there is an immediate and growing demand for accessible and scalable mental health solutions. Emotion-focused training for self-compassion and self-protection was developed and distributed using mobile phone technologies, and its effectiveness was tested. The available research sample consisted of 97 participants with a mean age of 26.06 years and a standard deviation of 10.53. Participants using the mobile app underwent a 14-day program aimed at reducing self-criticism while increasing self-compassion and self-protection. Pre- and post-measurements were collected. The results showed a statistically significant medium effect on self-compassion, self-criticism, and self-protection performance and a significant small effect on self-protection distress. The finding that a 14-day mobile app was able to foster well-being in the form of self-compassion, self-protection, and self-criticism is promising. It indicates the potential for individuals to obtain help through the use of remote tools such as MHapps for a fraction of the usual cost, at their own pace, and without other restrictions.
Correlation between CRISPR Loci Diversity in Three Enterobacterial Taxa

CRISPR-Cas is an adaptive immunity system of prokaryotes, composed of CRISPR arrays and the associated proteins. The successive addition of spacer sequences in the CRISPR array has made the system a valuable molecular marker, with multiple applications. Due to the high degree of polymorphism of the CRISPR loci, their comparison in bacteria from various sources may provide insights into the evolution and spread of the CRISPR-Cas systems. The aim of this study was to establish a correlation between the enterobacterial CRISPR loci, the sequence of direct repeats (DR), and the number of spacer units, along with the geographical origin and collection source. For this purpose, 3474 genomes containing CRISPR loci from the CRISPRCasdb of Salmonella enterica, Escherichia coli, and Klebsiella pneumoniae were analyzed, and the information regarding the isolates was recorded from the NCBI database. The most prevalent was the I-E CRISPR-Cas system in all three studied taxa. E. coli also presents the I-F type, but in a much lesser percentage. The systems found in K. pneumoniae can be classified into I-E and I-E*. The I-E and I-F systems have two CRISPR loci, while I-E* has only one locus upstream of the Cas cluster. PCR primers have been developed in this study for each CRISPR locus. Distinct clustering was not evident, but statistically significant relationships occurred between the different CRISPR loci and the number of spacer units. For each of the queried taxa, the number of spacers was significantly different (p < 0.01) by origin (Africa, Asia, Australia and Oceania, Europe, North America, and South America) but was not linked to the isolation source type (human, animal, plant, food, or laboratory strains).
Ensiling Improved the Colonization and Degradation Ability of Irpex lacteus in Wheat Straw

To develop a non-thermal method to replace steam autoclaving for white-rot fungi fermentation, Irpex lacteus spawn was inoculated in wheat straw (WSI) or ensiled WS (WSI) at varying ratios of 10%, 20%, 30%, 40%, and 50%, and incubated at 28 °C for 28 days to determine the effects of the ensiling and inoculation ratio on the colonization and degradation ability of Irpex lacteus in wheat straw (WS). The results demonstrate that ensiling effectively inhibited the growth of aerobic bacteria and molds, as well as other harmful microorganisms in WS, which created a favorable condition for the growth of I. lacteus. After the treatment of I. lacteus, the pH of EWSI decreased to below 5, while that of WSI, except for the feedstocks of WSI-50%, was around 7, indicating that I. lacteus colonized well in the ensiled WS because the substrates dominated by I. lacteus are generally acidic. Correspondingly, except for the molds in WSI-50% samples, the counts of other microorganisms in WSI, such as aerobic bacteria and molds, were significantly higher than those in EWSI (p < 0.05), indicating that contaminant microorganisms had a competitive advantage in non-ensiled substrates. Incubation with I. lacteus did not significantly affect the cellulose content of all samples. However, the NDS content of EWSI was significantly higher than that of WSI (p < 0.05), and the hemicellulose and lignin contents were significantly lower than the latter (p < 0.05), except for the NDS and hemicellulose contents of WSI-50% samples. Correlation analysis revealed a stronger negative correlation between NDS content and the contents of hemicellulose, cellulose, and lignin in EWSI, which could be caused by the destruction of lignin and hemicellulose and the conversion from structural carbohydrates to fungal polysaccharides or other compounds in NDS form. Even for WSI-50% samples, the sugar yield of WS treated with I. lacteus improved with an increasing inoculation ratio, but the ratio was not higher than that of the raw material. However, the sugar yield of EWSI increased by 51–80%, primarily owing to the degradation of lignin and hemicellulose. Above all, ensiling improves the colonization ability of I. lacteus in WS, which promotes the degradation of lignin and hemicellulose and the enzymic hydrolysis of cellulose, so combining ensiling and I. lacteus fermentation has promising potential in the pretreatment of WS.
New Betulin Derivatives with Nitrogen Heterocyclic Moiety—Synthesis and Anticancer Activity In Vitro

As part of the search for new medicinal substances with potential application in oncology, the synthesis of new compounds combining the betulin molecule and the indole system was carried out. The structure of the ester derivatives obtained in the Steglich reaction was confirmed by spectroscopic methods (1H and 13C NMR, HR-MS). The obtained new 3-indolyl betulin derivatives were evaluated for anticancer activity against several human cancer cell lines (melanomas, breast cancers, colorectal adenocarcinomas, lung cancer) as well as normal human fibroblasts. The significant reduction in MCF-7 cells viability for 28-hydroxy-(lup-20(29)-ene)-3-yl 2-(1H-indol-3-yl)acetate was observed at a concentration of 10 µg/mL (17 µM). In addition, cytometric analysis showed that this compound strongly reduces the proliferation rate of breast cancer cells. For this, the derivative showing the promising cytotoxic effect on MCF-7 breast cancer cells, the pharmacokinetic profile prediction was performed using in silico methods. Based on the results obtained in the study, it can be concluded that indole-functionalized triterpene EB367 is a promising starting point for further research in the field of breast cancer therapy or the synthesis of new derivatives.