Miracle-dz/UniFAR-FTUs huggingface dataset:
Circ_0058063 upregulates GLUT1 expression and promotes glucose-uptake in esophageal squamous-cell carcinomas

Background CirRNA Circ_0058063 has been proven as an oncogene in bladder cancer, while its involvement in esophageal squamous-cell carcinomas (ESCC) is unknown. This study aimed to investigate the role of Circ_0058063 in ESCC. Methods Paired ESCC and non-tumor tissues were collected from ESCC patients and gene expression was analyzed by quantitative reverse transcription polymerase chain reaction (RT-qPCR). Gene interactions were analyzed by overexpression experiment. Glucose uptake was analyzed by glucose uptake assay. Cell proliferation was analyzed by cell proliferation assay. Results We found that Circ_0058063 was upregulated in ESCC and positively correlated with GLUT1 mRNA. It is known that GLUT1 plays critical roles in glucose transportation and glucose supports the Warburg Effect as the major metabolic precursor. In ESCC cells, Circ_0058063 and GLUT1 overexpression both promoted glucose uptake. In ECSS cells, Circ_0058063 overexpression resulted in the upregulated, while Circ_0058063 knockdown resulted in downregulated GLUT1. In cell proliferation assay, Circ_0058063 and GLUT1 overexpression resulted in the increased, while Circ_0058063 knockdown resulted in the decreased rate of ESCC cell proliferation. Moreover, GLUT1 overexpression reduced the effects of Circ_0058063 knockdown. Conclusions Circ_0058063 upregulates GLUT1 expression and promotes glucose-uptake in ESCC to promote cell proliferation.
Blockchain-Based Identity Authentication and Intelligent Credit Reporting

This paper elaborates on the blockchain-based identity authentication and intelligent credit reporting method. The technologies of multidimensional authentication, multifactor weighted score calculation, security threshold, distributed ledger, smart contract and encryption algorithm are proposed to realize dynamic identity security authentication and intelligent risk control. The user behaviour analysis system, real-time risk identification system and intelligent risk prevention system are constructed. The multidimensional credit data collection is realized through blockchain distributed nodes. The distributed ledger of credit reporting, intelligent pricing of assets and automatic credit rating of users are proposed. It realizes credit reporting system and service based on multidimensional data, distributed ledgers, and smart contracts.
Assessing Video Game Habits and Pathological Behaviour in Children through a New Scale: Psychometric Properties of the Video-Gaming Scale—For Children (VGS-C)

The purpose of this study was to develop an instrument to assess video-gaming habits and pathological behavior in children. The Video Game Scale—For Children (VGS-C) was developed by adapting the VGS—For Adolescents (VGS-A). The final scale was composed of two sections: Section A, with unscored items, assessing a wide series of video-gaming habits, and Section B, with scored items, measuring pathological use of video games by adapting the DSM—5 criteria for Internet Gaming Disorder. Participants were 201 children attending primary school in Italy (47% males; mean age = 8.7 years). Concerning Section A, preferred video games, daily frequency of video-gaming, used devices, amount of time spent on video game sessions, gaming on Internet, preferred online video games, and social partners in playing video games, were analyzed. Regarding Section B, Confirmatory Factor Analysis attested the hypothesized one-factor structure, and an adequate reliability was found. The association of video-gaming habits with pathological video-gaming attested the validity of the scale. Tolerance and escape were the pathological symptoms more frequently experienced by children. Findings suggest that the VGS-C could be a valuable instrument to assess video-gaming habits and pathological behavior in children.
Religious Heads’ Perspectives towards the Abolition of ChildMarriage: A Study in Malang, East Java, Indonesia

The move to abolish child marriages in Indonesia has met with obstacles from religious leaders. This is probably due to the limited research involving religious heads’ perspectives towards the abolition of child marriages. This article will explore the perspectives of Religious Affairs (KUA) Heads in Malang City. These officials are in charge of overseeing issues with regards marriage within the Muslim community. The design of this study was a qualitative case study and data sources were obtained from KUA Heads in Malang City. Semi-structured interview instruments were used, and data analysis was done through thematic analysis. The results of the study revealed that all the respondents agreed to the abolishment of child marriages, as well as in agreeing to propose the revision of the marriage law (No.1 of 1974), which would be by raising the age limit of marriage of girls from 16 years to 18 years. However, dispensation for marriage would be provided for those aged less than 18 years in some special conditions. It was also found that for this revision to take place, abolition of child marriage must be entirely supported by parents, teachers, religious and community leaders.
Effects of Hydraulic Loading Rate on Spatial and Temporal Water Quality Characteristics and Crop Growth and Yield in Aquaponic Systems

Aquaponics is a rapidly growing food-production system integrating aquaculture and hydroponic crop production through an energy-intensive water recirculation process. Crop performance and yield in aquaponics are affected by essential and toxic nutrient levels in the root zone, which can be regulated by water flow rate. This study was conducted to examine the effects of hydraulic loading rate (HLR) on water quality and crop growth and yield in recirculating aquaponic systems set at three different loading rates: high (3.3 m3/m2/day; HFR, which is 12 times lower than recommended loading rate), medium (2.2 m3/m2/day; MFR), and low (1.1 m3/m2/day; LFR). Crop species varying in growth rate were examined for their optimal HLR: fast-growing Chinese cabbage (Brassica rapa) and lettuce (Lactuca sativa); medium-growing mustard (Brassica juncea) and chia (Salvia hispanica); and slow-growing basil (Ocimum basilicum) and Swiss chard (Beta vulgaris). Compared to LFR, HFR decreased water and leaf temperatures and total ammonium nitrogen (TAN) but increased dissolved oxygen and pH in aquaponic solution up to one and two weeks after transplant, respectively. HFR increased NO3–N concentration by 50 and 80%, respectively, compared to MFR and LFR, while reducing the exposure duration of roots to ammonia (NH3–N) and its peak concentration through rapid dissipation of the toxic compound. Lower electrical conductivity (EC) in HFR during the last two weeks of production was associated with higher plant nutrient uptake and greater biomass production. The leaf greenness, photosynthetic rate (Pn), and total plant N were significantly higher at HFR than LFR. Fish growth rate, fresh weight, and feed-conversion efficiency were also increased by HFR. The growth of fast-growing crops including total fresh weight, shoot fresh weight, leaf area, and Pn was not different between HFR and MFR, while HLR had less significant effects on the growth and performance (i.e., shoot fresh weight and whole plant photosynthesis) of slow-growing crops. In conclusion, the flow rate is an important component in aquaponic crop production as it affects spatial and temporal water characteristics and subsequently determines the growth and yield of the crops. HLR at 3.3 m3/m2/day was sufficient across the crops allowing better chemical and physical properties of the aquaponic solution for maximum yield and quality. HLR should be maintained at least at 2.2 m3/m2/day for the production of fast-growing crops but can be lowered for slow-growing crops.
Comparison between the Clinical Assessment, Peripheral Nerve Stimulation (PNS), and Acceleromyography (AMG) to Reverse Neuromuscular Blockade

BACKGROUND: Traditionally, most of anesthesiologists in Iraq evaluate the degree of neuromuscular blockade during and after anesthesia using clinical criteria alone, which are inaccurate to assess adequate recovery from neuromuscular block (NMB) which is essential for the patient to have full control of pharyngeal and respiratory muscles. Fade cannot be detected reliably with a peripheral nerve stimulator (PNS) at a TOF ratio > 0.4. The time gap between losses of visual fade by using a PNS until objective TOF ratio has returned to > 0.90 can be considered “the potentially unsafe period of recovery. ” OBJECTIVE: To compare between assessment of subjective clinical, subjective TOF by peripheral nerve stimulation (PNS), and objective TOF by acceleromyography (AMG) before reversal of neuromuscular blockade PATIENT AND METHOD: A prospective clinical trial of one hundred females who underwent caesarian section under general anesthesia. Standard anesthesia was conducted for all patients. Giving of neuromuscular reversal was decided by the anesthesia care providers depending on clinical criteria, at that time, TOF measured by 2 ways, 1 st : counting the twitches visually (principal of PNS), and 2 nd
A practical framework to facilitate constructability implementation using the integrated project delivery approach: a case study

Abstract Having integrated contractual strategies for projects and developing a transparent and unambiguous contract is highly effective for properly implementation of constructability. This study uses integrated project delivery (IPD) as the most recent contractual delivery approach to facilitate easier constructability implementation in the construction industry. The aim of this study is to present a practical framework to reduce changes and duplications, and facilitate constructability through focusing on the IPD approach. A case study on mass housing projects in Tehran is applied to provide supportive research data. This study uses qualitative analyses of data from both literature and the case study. Previously, comprehensive studies have been done by the authors through conducting a meta-synthesis technique. Outputs of the study, which were barriers and solutions to facilitate constructability implementation, are used in this study as presumptions. Data was collected from in-depth interviews with expert, including owners, consultants and contractors. The results were classified and compared with each other through descriptive and pattern analyses using the NVIVO Software. As determining constructability of a project needs experience and expertise, lack of constructability can be due to late or improper decision making in planning and design. The outcome of this study shows that `IPD implementation facilitates such harmony and coordination. The case is from Tehran of Iran. Given the geographical restriction of this case study that was in Iran, there were not adequate experts in the field of IPD. Currently, in Iran, these concepts are just implemented in large projects. This study uses IPD as the most recent contractual delivery approach to facilitate easier constructability implementation in the construction industry. Having coordination between construction and pre-construction stages is very significant to reduce duplications and improve real implementation of designs.
RISK FACTORS OF METABOLIC SYNDROME IN PREGNANCY INDUCED HYPERTENSION CASES

Hypertensive disorders complicating pregnancy are common and form great triad along with hemorrhage and infection. They are one of the important causes resulting in maternal and fetal morbidity and mortality. Metabolic syndrome is a combination of medical disorders that, when occurs together, it increases the risk of developing cardiovascular disease and diabetes. In order to know the risk of development of metabolic syndrome in women with PIH, the risk factors for metabolic syndrome like total cholesterol, HDL cholesterol, triglycerides and fasting blood sugar levels of PIH women as compared to their normotensive counterparts have been measured, analyzed and compared with earlier studies. The PIH women group exhibited highly significant increase in fasting blood sugar level, significant increase in total cholesterol and triglyceride levels and an insignificant decrease in HDL cholesterol. These results indicate that there is a significant association of abnormal lipid profiles and increased fasting blood sugar levels in PIH women.
Promoting employee job crafting at work: the roles of motivation and team context

Despite receiving much attention in recent job design literature, job crafting research has neglected motivational and multilevel perspectives, limiting the understanding of how to foster employee job crafting. Drawing on job crafting and self-determination theory, the purpose of this paper is to explore individual- and team-level predictors and the mechanisms involved in employees’ job change behaviors. The authors propose that employees’ intrinsic motivation and two team-level properties – team knowledge sharing and trust – have important roles to play. ,The multilevel data were collected from 311 employees from 62 work teams in Korean companies. Hierarchical linear modeling analysis was used. A supplementary data collected from 162 individuals working in the USA were used for analysis. ,The results showed that intrinsic motivation and team knowledge sharing are positively related to job crafting. In addition, intrinsic motivation mediated the relationship between team knowledge and individual job crafting. Finally, team trust was shown to play a cross-level moderating role, strengthening the positive relationship between employees’ intrinsic motivation and job crafting. ,Applying motivational and multilevel perspectives, this paper uncovers the roles of individual motivation and team context in fostering employee job crafting. This study helps to extend the theoretical domains of job crafting and provides practical insights into how to promote employees’ job crafting.
Teachers Know, but We Do Too: The Case of Mayan Parents’ Assessment Knowledge

ABSTRACT Parents’ conceptions of assessment are important as they have a key role in supporting their child’s educational goals. Through two focus group interviews conducted in Spanish, Mayan mothers (N = 8) discussed their experiences acquiring assessment knowledge. The results suggest that the parents held basic conceptions of assessment, and described different assessment experiences for different purposes. The study highlights how parents interact with different stakeholders when reaching out for assessment information, and how they balance the needs of their child, family, and community. The overall implications can help parents ask assessment questions, become more knowledgeable in the educational process, and inform teacher education programs on how to talk to parents.
A review of seismological research in India during the past five years (2015-2019)

The Indian plate has a unique history of evolution subsequent to its separation from the Gondwana supercontinent. At present, it is a collage of complex structural terranes of varied geology, ranging from collision, subduction, paleo rifts, mobile belts, cratons and basins (Fig. 1). During the past five years, several seismological studies have been undertaken at various geological terrains by many organisations and individuals to decipher the crustal architecture, seismotectonics, geodynomics and earthquake occurrence processes in the plate boundary as well as in the plate interiors. Significant efforts have been made to estimate the source parameters (both dynamic and static) of the earthquakes which have occurred in the Indian subcontinent. GPS measurements have been made at a number of sites to determine the convergence rate, strain budget and role of various tectonic units in accommodating the plate motion. A major initiative was taken up by the Ministry of Earth Sciences to upgrade and upscale the national seismological network. We have restricted this review to some significant work done by the Indians on the Indian landmass. We do not claim that this is an exhaustive review, and any omissions are unintentional. Crustal Architecture of the Indian Subcontinent
Calendar Rotations: A New Approach for Studying the Impact of Timing using Earnings Announcements

We develop a novel methodology for studying the causal impact of announcement timing. Our methodology uses firms' earnings announcements and leverages quasi-exogenous variation attributable to the specific day-of-week on which a calendar month begins. We refer to the resulting variation in announcement timing as 'calendar rotations,' which are uncorrelated with proxies for announcement content. In applying our methodology, we show announcements moved forward by calendar rotations receive heightened media and investor attention, and experience greater earnings announcement premia. Taken together, our study details a method for studying how the timing of information flows impacts outcomes of interest to financial economists.
Psychiatric Morbidity in Epilepsy; A Cross Sectional Hospital Based Study

Background:Previous work has identified prevalence rate for psychiatric disorders in individual with epilepsy and its correlation. However studies from this part of country are quite a few, and no systematic attempt has earlier been made to study prevalence, nature of psychopathology ,and any correlation of duration of psychiatric illness with duration of epilepsy. Aims: i)To find out the nature of psychiatric illness presenting with epilepsy ,presenting to psychiatry department with history of epilepsy. ii)To find out the correlation of the psychiatric illness with the duration, treatment and family history of epilepsy. Method:43 cases of psychiatric illness were selected by using a serial sampling method, from the patients attending both in-patient and out-patient services of the Department of Psychiatry A.M.C.H, Dibrugarh, during the period from January 2006 to February 2007. Results: There was a significant association between psychiatric illness and epilepsy and its durations. 99% linear and mutual relationship exist between type of seizure and psychiatric illness, so far their rank is concerned. Connecting this if we go far the correlation test related to their respective duration then it is found to be 0.9746 which is significant . Prevalence of schizophrenia is 44.18%, and depression 9.3%. Conclusion:Study shows significant association between epilepsy and psychiatric illness, study also shows significant association between duration of onset psychiatric illness and duration of onset of epilepsy. Prevalence of schizophrenia in epileptic patients to be much higher, However prevalence of depression is less than prevalence of studies in the past.
Awareness of labour analgesia among antenatal women in semi urban area

ABSTRACT Background: Women’s experience of pain during delivery varies greatly. Various pharmacological and non- pharmacological methods of labour analgesia are available. In spite of availability of various methods, even now women deliver with severe pain without adequate pain relief. The aim of the study was to determine the awareness of pregnant women about labour analgesia in semi urban setting. Methods: This cross sectional study was done among 256 pregnant women attending antenatal out-patient in obstetrics and gynecology department. Antenatal women who were planned for elective cesarean section were excluded from the study. Results: Out of 256 women 89.8% had no idea about usage of pain relief in labour. Only 10.2% had some idea about pain relief in labour. In previous delivery, 38.9% experienced severe pain, 58.4% experienced moderate pain and only 2.7% experienced mild pain. Some form of analgesia was administered to 89.9% of women. In spite of analgesia being given for majority, more number of women experienced moderate and severe pain (97.3%). On analyzing various factors, order of pregnancy, income and occupational status had statistically significant influence on knowledge about labour analgesia. Conclusions: There is a lack of knowledge among pregnant women about pain relief. Due to hectic work in labour room setting in India, it may be difficult to provide one to one care. Non-pharmacological methods should be popularized for pain relief. Usage of some form of pain relief will help in improving quality of care during labour and better outcome of mother and baby.
Teaching with interactive whiteboards : is teacher education up to it? : a study of pre-service primary school teachers’ education with interactive whiteboards

Without quality teaching and learning based around a solid understanding of sound pedagogical principles, IWBs will be just another piece of hardware in the classroom. Unless teachers understand how to leverage interactive technology to create better learning experiences for their students, then we are wasting our time (Betcher & Lee, 2009, p .13). Given the increasing prevalence of Interactive Whiteboards (IWBs) in Australian primary school classrooms, this study aimed to determine how well the teacher education course at the University of Tasmania (UTAS) was meeting the needs of pre-service teachers. Variables, including perceived usefulness, perceived ease of use, perceptions of technological complexity, technological self-efficacy, attitude towards computer use, and facilitating conditions, potentially influencing the acceptance of this technology, as described by Teo (2009), were examined, and connections between participants’ perceptions identified. This study sought to compare the IWB education received by pre-service teachers at UTAS with IWB use in primary school classrooms, with the aim of determining the readiness of beginning teachers to embrace this technology. Surveys and interviews were conducted with pre-service teachers at UTAS, Faculty of Education teaching staff at UTAS, and primary school teachers, with the results compared and interpreted in light of the existing research findings as presented in the literature review. There was a disjuncture between how IWBs were used in primary school classrooms and how they were used at university. Pre-service teachers were on average more positive in their perceptions about IWB use than were university teaching staff. Low levels of education in IWB use and limited access to the technology were reported by the majority of pre-service teachers and Faculty of Education teaching staff. There was also a difference among expectations for IWB use of the three groups participating in this study. The results of this study are relevant and of interest to educators and university leadership in Australia and beyond.
Determinants of strategy disclosure quality: empirical evidence from Germany

Strategy reporting is of high interest to investors and can be seen as decision-useful information. The focus of this study is to analyze the determinants of the quality of voluntary strategy disclosure in German management reports of capital market-oriented companies. Based on a theoretical analysis, hypotheses are formulated to investigate the determinants of the quality of voluntary strategy disclosure. In order to test the hypotheses, a number of statistical tests are performed, especially multiple regression analyses. It is based on a unique hand-collected dataset with a self-constructed scoring model, which measures the quality of voluntary strategy disclosure. The sample comprises 110 largest companies in Germany for the period between 2014 and 2018. The results indicate that firm size, firm growth and capital intensity determine voluntary strategy disclosure significantly and positively. Conversely, firm age, financial leverage, ownership structure and profitability do not have a significant relationship with voluntary strategy disclosure. The results are robust to different statistical analysis. This research provides insights into a neglected topic in academia and helps decision-makers in practice and regulators to better understand voluntary strategy disclosure of capital market-oriented companies.