Miracle-dz/UniFAR-FTUs huggingface dataset:
Systolic Blood Pressure and 1-Year Clinical Outcomes in Patients Hospitalized for Heart Failure

Background High systolic blood pressure (SBP) is an important risk factor for the progression of heart failure (HF); however, the association between SBP and prognosis among patients with established HF was uncertain. This study aimed to investigate the association between SBP and long-term clinical outcomes in patients hospitalized for HF. Methods This study prospectively enrolled adult patients hospitalized for HF in 52 hospitals from 20 provinces in China. SBPs were measured in a stable condition judged by clinicians during hospitalization before discharge according to the standard research protocol. The primary outcomes included 1-year all-cause death and HF readmission. The multivariable Cox proportional hazards regression models were fitted to examine the association between SBP and clinical outcomes. Restricted cubic splines were used to examine the non-linear associations. Results The 4,564 patients had a mean age of 65.3 ± 13.5 years and 37.9% were female. The average SBP was 123.2 ± 19.0 mmHg. One-year all-cause death and HF readmission were 16.9 and 32.7%, respectively. After adjustment, patients with SBP < 110 mmHg had a higher risk of all-cause death compared with those with SBP of 130–139 mmHg (HR 1.71; 95% CI: 1.32–2.20). Patients with SBP < 110 mmHg (HR 1.36; 95% CI: 1.14–1.64) and SBP ≥ 150 mmHg (HR 1.26; 95% CI: 1.01–1.58) had a higher risk of HF readmission, and the association between SBP and HF readmission followed a J-curve relationship with the nadir SBP around 130 mmHg. These associations were consistent regardless of age, sex, left ventricular ejection fraction, hypertension, coronary heart disease, and medications for HF. Conclusion In patients hospitalized for HF, lower SBP in a stable phase during hospitalization portends an increased risk of 1-year death, and a J-curve association has been observed between SBP and 1-year HF readmission. These associations were consistent among clinically important subgroups.
Multisystem Inflammatory Syndrome Temporally Related to COVID-19 in Children From Latin America and the Caribbean Region: A Systematic Review With a Meta-Analysis of Data From Regional Surveillance Systems

Background With the emergence of the COVID-19 pandemic, increasing numbers of cases of the multisystem inflammatory syndrome in children (MIS-C) have been reported worldwide; however, it is unclear whether this syndrome has a differential pattern in children from Latin America and the Caribbean (LAC). We conducted a systematic review and meta-analysis to analyze the epidemiological, clinical, and outcome characteristics of patients with MIS-C in LAC countries. Methods A systematic literature search was conducted in the main electronic databases and scientific meetings from March 1, 2020, to June 30, 2021. Available reports on epidemiological surveillance of countries in the region during the same period were analyzed. Results Of the 464 relevant studies identified, 23 were included with 592 patients with MIS-C from LAC. Mean age was 6.6 years (IQR, 6–7.4 years); 60% were male. The most common clinical manifestations were fever, rash, and conjunctival injection; 59% showed Kawasaki disease. Pool proportion of shock was 52%. A total of 47% of patients were admitted to the pediatric intensive care unit (PICU), 23% required mechanical ventilation, and 74% required vasoactive drugs. Intravenous gamma globulin alone was administered in 87% of patients, and in combination with steroids in 60% of cases. Length of hospital stay was 10 days (IQR, 9–10) and PICU stay 5.75 (IQR, 5–6). Overall case fatality ratio was 4% and for those hospitalized in the PICU it was 7%. Conclusion Limited information was available on the clinical outcomes. Improvements in the surveillance system are required to obtain a better epidemiologic overview in the region.
How Does Emotion Influence Time Perception? A Review of Evidence Linking Emotional Motivation and Time Processing

Emotions have a strong influence on how we experience time passing. The body of research investigating the role of emotion on time perception has steadily increased in the past twenty years. Several affective mechanisms have been proposed to influence the passing of time. The current review focuses on how three dimensions of affect—valence, arousal, and motivation—are related to time perception. The valence-based model of time perception predicts that all positive affects hasten the perception of time and all negative affects slow the perception of time. Arousal is thought to intensify the effects of the influence of valence on time perception. In much of this past work, motivational direction has been confounded with valence, whereas motivational intensity has been confounded with arousal. Research investigating the role of motivation in time perception has found that approach-motivated positive and negative affects hasten the perception of time, but withdrawal-motivated affects slow the perception of time. Perceiving time passing quickly while experiencing approach-motivated states may provide significant advantages related to goal pursuit. In contrast, perceiving time passing slowly while experiencing withdrawal-motivated states may increase avoidance actions. Below, we review evidence supporting that approach motivation hastens the passing of time, whereas withdrawal motivation slows the passing of time. These results suggest that motivational direction, rather than affective valence and arousal, drive emotional changes in time perception.
Risk Entanglement in the Finance-State Nexus: The Case of Systemic and Political Risk

Crises such as European debt crisis, Brexit, and COVID-19 have challenged established relations between finance and the state in attempts at mitigating a broad range of crises-related risks. We ask whether and how these altered relations in themselves constitute novel uncertainties and risks between the two fields. To better understand these dynamics, we introduce the concept of “risk entanglement” to complement financialization as a key concept presently capturing these relations. Based on qualitative research in the German finance-state nexus, we show how financial and state actors mutually construe each other as risks that need to be managed and mitigated to safeguard their particular, field-specific logics and ends. We focus on systemic risk and political risk as two cases of risk entanglement: whereas systemic risk reflects the threat of a potential financial meltdown to the state, political risk reflects how the state endangers established risk practices in finance.
A Novel miRNA From Egg-Derived Exosomes of Schistosoma japonicum Promotes Liver Fibrosis in Murine Schistosomiasis

Schistosomiasis caused by Schistosoma japonicum is a serious public health problem in China. Granuloma and hepatic fibrosis are the main pathological features of schistosomiasis japonica. The role and mechanism of egg-derived exosomes of S. japonicum in liver fibrosis remain unclear. In this study, we found that egg-derived exosomes of S. japonicum carry a new type of microRNA (miRNA-33). In vitro, this novel miRNA upregulated the expression of smooth muscle actin (α-SMA) and collagen 1 α1 (Col 1 α1) in the human hepatic stellate cell (LX-2) line at both mRNA and protein levels. In vivo, this novel miRNA was upregulated in the serum of infected mice, and when injected into mice through the tail vein using miRNA agomir, α-SMA, Col 1 α1, and Col 3 α1 were upregulated in liver tissue at both mRNA and protein levels. In addition, this novel miRNA downregulated the expression of α-SMA and Col 1 α1 in liver tissue at mRNA and protein levels in mice infected with S. japonicum and treated with miRNA antagomir. The novel miRNA-33 upregulated TGF-β Receptor I (TGF-β RI) at both mRNA and protein levels in LX-2 cells. Our results suggest that this novel miRNA from egg-derived exosomes of S. japonicum can promote liver fibrosis in the host in a cross-species manner, and the degree of fibrosis can be decreased by inhibiting the expression of this miRNA.
Visuomanual Vertical Prism Adaptation: Aftereffects on Visuospatial and Auditory Frequency Representations

Sensorimotor aftereffects have been widely studied after lateral prism adaptation but not after vertical prism adaptation. It is thus well-known that lateral prism adaptation produces aftereffects on visuospatial representation and, recently, on auditory perception. This study aimed to explore the sensorimotor after-effects of vertical prism adaptation as well as its aftereffects on vertical visuospatial representation (Experiment 1) and on auditory frequency representation (Experiment 2). The experimental procedure was similar in both experiments: before and after prism adaptation to an upward or a downward optical deviation, healthy young participants performed an visual open-loop pointing task and a visual (Experiment 1) or an auditory (Experiment 2) perceptual bisection task. In the visual task, the participants had to indicate if they perceived the bisection as higher or lower than the true center of a line. In the auditory task, the participants had to indicate if they perceived the target auditory frequency closer to the low or the high limit of an auditory interval. For sensorimotor aftereffects, pointing errors were computed by means of a vertical touchscreen. For the perceptual bisection task, we measured the percentage of “down” (Experiment 1) or “low” responses (Experiment 2), and we computed the visual (Experiment 1) or the auditory (Experiment 2) subjective center for each participant. Statistical analyses were carried out separately for each optical deviation in each experiment. Sensorimotor aftereffects were observed in both experiments, in the opposite direction to the optical deviation (all ps < 0.01). No significant aftereffects occurred on visuospatial representation (all ps > 0.5), whereas the percentage of “low” responses and the auditory subjective center significantly increased after adaptation to a downward optical deviation (all ps < 0.05). Unlike lateral prism adaptation aftereffects that have been previously shown in both visuospatial horizontal representation and auditory frequency representation, aftereffects of vertical prism adaptation occurred in the auditory frequency representation but not in the vertical visuospatial representation. These results suggest that both vertical and lateral prism adaptations share a common substrate dedicated to the auditory modality (probably the temporal cortex), and that vertical adaptation does not act on the neural substrate of vertical visuospatial representation.
Repeatable Territorial Aggression in a Neotropical Poison Frog

Intra-specific aggressive interactions play a prominent role in the life of many animals. While studies have found evidence for repeatability in boldness, activity, and exploration in amphibians, we know relatively little about consistent among-individual variation in aggressiveness, despite its importance for male-male competition and territoriality. Amphibians, and Neotropical poison frogs (Dendrobatidae) in particular, are highly suitable for investigating among-individual variation in aggressiveness, as most species exhibit strong territoriality in at least one of the sexes. In the present study, we aimed to fill this gap in knowledge, by investigating within- and between-individual variation in territorial aggression in a semi-natural population of the Neotropical poison frog Allobates femoralis (Dendrobatidae) in French Guiana. We conducted repeated, standardized behavioral tests to assess if the level of territorial aggression is consistent within and different between individuals. Further, we tested a possible link between body size and level of territorial aggression. We found moderate repeatability in territorial aggressiveness, but no link to age and/or body size. In conclusion, our study represents the first documentation of repeatable aggressive behavior in a territorial context in amphibians.
HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed Patients in Portugal Between 2014 and 2019

Objective To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were used for subtyping, TDR determination, and transmission cluster (TC) analyses. Results In Portugal, the overall prevalence of TDR between 2014 and 2019 was 11.0%. TDR presented a decreasing trend from 16.7% in 2014 to 9.2% in 2016 (pfor–trend = 0.114). Multivariate analysis indicated that TDR was significantly associated with transmission route (MSM presented a lower probability of presenting TDR when compared to heterosexual contact) and with subtype (subtype C presented significantly more TDR when compared to subtype B). TC analysis corroborated that the heterosexual risk group presented a higher proportion of TDR in TCs when compared to MSMs. Among subtype A1, TDR reached 16.6% in heterosexuals, followed by 14.2% in patients infected with subtype B and 9.4% in patients infected with subtype G. Conclusion Our molecular epidemiology approach indicates that the HIV-1 epidemic in Portugal is changing among risk group populations, with heterosexuals showing increasing levels of HIV-1 transmission and TDR. Prevention measures for this subpopulation should be reinforced.
A novel source-to-drain nonuniformly doped channel (NUDC) MOSFET for high current drivability and threshold voltage controllability

A novel source-to-drain nonuniformly doped channel (NUDC) MOSFET was investigated theoretically and experimentally. Using an analytical model, it is verified that the mobility of the NUDC MOSFET is increased as compared with that of the conventional channel MOSFET. Also, the V/sub th/ lowering of the NUDC MOSFET is suppressed as compared with that of the conventional channel MOSFET. The NUDC MOSFET was fabricated by the oblique rotating ion implantation technique, and the theoretical predictions were confirmed experimentally. <<ETX>>
Effect of lncRNA MALAT1 on the Granulosa Cell Proliferation and Pregnancy Outcome in Patients With PCOS

Follicle arrest is one of the main characteristics of polycystic ovary syndrome (PCOS), the most common endocrinological disorder in reproductive-aged women. Increasing evidence proves that high anti-Mullerian hormone (AMH) levels may play an important role in follicular development. Long noncoding RNA (lncRNA) with a length of more than 200 nt is widely involved in the directional differentiation, growth, and development of cells, whereas whether lncRNA is involved in AMH’s role in follicular development is unknown. In this study, we analyzed lncRNA expression in ovarian granulosa cells (GCs) collected from women with and without PCOS via high-throughput sequencing. The results showed that a total of 79 noncoding transcripts were differently expressed in GCs of PCOS patients, including upregulated lncRNA MALAT1. The upregulation of MALAT1 was further confirmed by RT-qPCR in GCs from a larger cohort of PCOS patients. Furthermore, knockdown MALAT1 can promote the proliferation of KGN cell in vitro. These data suggested a role for MALAT1 in the development of PCOS. Meanwhile, MALAT1 and phosphorylated SMAD 1/5 (Ser463/465) protein were upregulated in KGN cells after exogenous AMH stimulation, which identified AMH perhaps as a regulator for the expression of MALAT1. We also found that MALAT1 can predict clinical pregnancy outcome to a certain extent by ROC curve analysis (area: 0.771, p = 0.007, 95% CI: 0.617–0.925, sensitivity: 57.1%, specificity: 91.7%). Thus, our findings revealed a role of lncRNA MALAT1 in inhibiting granulosa cell proliferation and may be correlated with pregnancy outcome in PCOS.
Effect of Arm Movement and Task Difficulty on Balance Performance in Children, Adolescents, and Young Adults

Background Studies have shown that restricted compared to free arm movement negatively affects balance performance during balance assessment and this is reinforced when the level of task difficulty (e.g., varying stance/walk conditions, sensory manipulations) is increased. However, it remains unclear whether these findings apply to individuals with differences in the development of the postural control system. Thus, we examined the influence of arm movement and task difficulty on balance performance in children, adolescents, and young adults. Methods Static, dynamic, and proactive balance performance were assessed in 40 children (11.5 ± 0.6 years), 30 adolescents (14.0 ± 1.1 years), and 41 young adults (24.7 ± 3.0 years) using the same standardized balance tests [i.e., one-legged stance (OLS) time with eyes opened/closed and/or on firm/foam ground, 3-m beam (width: 6, 4.5, or 3 cm) walking backward step number, Lower Quarter Y-Balance test (YBT-LQ) reach distance] with various difficulty levels under free vs. restricted arm movement conditions. Results In all but one test, balance performance was significantly better during free compared to restricted arm movement. Arm by age interactions were only observed for the YBT-LQ and post hoc analyses revealed significantly greater performance differences between free and restricted arm movement, especially, in young adults. Arm by age by task difficulty interactions were found for the OLS and the 3-m beam walking backward test. Post hoc analyses showed significantly greater performance differences between free and restricted arm movement during high vs. low levels of task difficulty and this was more pronounced in children and adolescents. Conclusions Regardless of age, static, dynamic, and proactive balance performance benefited from arm movements and this was especially noted for youth performing difficult balance tasks.
Phosphorylation and calcium antagonistically tune myosin- Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function binding protein C's structure and function Let us know how access to this document benefits you.

During each heartbeat, cardiac contractility results from calcium- activated sliding of actin thin filaments toward the centers of myosin thick filaments to shorten cellular length. Cardiac myosin-binding protein C (cMyBP-C) is a component of the thick filament that appears to tune these mechanochemical interactions by its N-terminal do- mains transiently interacting with actin and/or the myosin S2 domain, sensitizing thin filaments to calcium and governing maximal sliding velocity. Both functional mechanisms are potentially further tunable by phosphorylation of an intrinsically disordered, extensible region of cMyBP-C ’ s N terminus, the M-domain. Using atomic force spectroscopy, electron microscopy, and mutant protein expression, we dem- onstrate that phosphorylation reduced the M-domain ’ s extensibility and shifted the conformation of the N-terminal domain from an ex- tended structure to a compact configuration. In combination with motility assay data, these structural effects of M-domain phosphory- lation suggest a mechanism for diminishing the functional potency of individual cMyBP-C molecules. Interestingly, we found that calcium levels necessary to maximally activate the thin filament mitigated the structural effects of phosphorylation by increasing M-domain ex- tensibility and shifting the phosphorylated N-terminal fragments back to the extended state, as if unphosphorylated. Functionally, the ad- dition of calcium to the motility assays ablated the impact of phosphorylation on maximal sliding velocities, fully restoring cMyBP-C ’ s inhibitory capacity. We conclude that M-domain phosphorylation may have its greatest effect on tuning cMyBP-C ’ s calcium-sensitiza-tion of thin filaments at the low calcium levels between contractions. Importantly, calcium levels at the peak of contraction would allow cMyBP-C to remain a potent contractile modulator, regardless of cMyBP-C ’ s phosphorylation state. global interactions between cMyBP-C ’ s N-terminal domains. phosphorylation-dependent structural changes a molecular basis for cMyBP-C ’ s ability to modulate cardiac contractility. In addition, we identify another novel modulatory mechanism by which calcium limits these intra- and interdomain structural inter- actions and the ability of cMyBP-C phosphorylation to affect function. Our findings suggest that phosphorylation and calcium can antagonistically fine-tune cMyBP-C ’ s modulation of cardiac contractility, so that phosphorylation plays its greatest role when calcium levels within the sarcomere are low. The mechanistic phenomena described here may apply to
Effect of Fatiguing Wheelchair Propulsion and Weight Relief Lifts on Subacromial Space in Wheelchair Users

Objective This study aimed to identify targets of intervention for reducing shoulder pain in wheelchair users with spinal cord injury (SCI) by (1) examining changes in subacromial space [acromiohumeral distance (AHD) and occupation ratio (OccRatio)] with fatiguing wheelchair propulsion, and different loading conditions [unloaded position vs. weight relief lifts (WRL)]; (2) associating these changes with wheelchair user capacity, as well as (3) identifying subject characteristics associated with subacromial space, such as sex, lesion level, time since injury, body mass index and impaired shoulder range of motion. Methods Fifty manual wheelchair users with SCI [11 females, age = 50.5 (9.7) years, time since injury = 26.2 (11.4) years] participated in this quasi-experimental one-group pretest-posttest study. Ultrasound images were used to define AHD during an unloaded position, and during personal and instructed WRL before and after fatiguing wheelchair propulsion. Furthermore, supraspinatus and biceps thickness defined from ultrasound images were used to calculate OccRatios. Wheelchair user capacity was quantified as functional strength (maximum resultant force reached during maximum isometric forward push) and anaerobic work capacity (highest power output reached during 15-m sprint test). Multilevel mixed-effects linear regression analyses controlling for between subject variability and covariables were performed to address the research questions. Results AHD was significantly smaller during personal WRL (p < 0.001) and instructed WRL (p = 0.009, AHD both 11.5 mm) compared to the unloaded position (11.9 mm). A higher wheelchair user capacity (higher anaerobic work capacity) reduced the impact of WRL on AHD decrease. The fatiguing wheelchair propulsion had no effect on AHD (p = 0.570) and on OccRatio of supraspinatus (p = 0.404) and biceps (p = 0.448). Subject characteristics related to a larger subacromial space were lower lesion level, shorter time since injury, impaired external rotation, a lower body mass index and a higher anaerobic work capacity. Conclusion This study showed a significant reduction in AHD during WRL with no effect of fatiguing wheelchair propulsion on the subacromial space in wheelchair users with SCI. A higher anaerobic work capacity was beneficial in stabilizing the shoulder during WRL. Our findings may assist clinicians in designing a shoulder injury prevention program.