Miracle-dz/UniFAR-FTUs huggingface dataset:
MORAL HARASSMENT IN PRIMARY CARE ACCORDING TO NURSING PROFESSIONALS

This study aimed to investigate the view nursing professionals have of moral harassment and how to identify these situations as experienced by the professionals in this area, as well as their causes and consequences for these workers' health. This is a qualitative exploratory research study in which 15 nursing professionals working at family health facilities in the city of João Pessoa, state of Paraíba, Brazil took part. Data collection took place between April and May 2013 by means of a recorded interview. The data were analyzed using the content analysis tech-nique. The analysis of the material revealed three categories: Moral harassment: Concept and characte-ristics from the nursing professionals' viewpoint; Moral harassment behaviors experienced by nursing professionals, and Consequences of the moral harassment. We conclude that moral harassment is wides-pread among nurses and nursing technicians, although some professionals understand the concept of this practice, and the prevalence of the descending type is notorious.
CONVENTIONAL AND MOLECULAR DETECTION OF MYCOBACTERIUM BOVIS IN ABURDEN ANGUS CATTLE AND HUMAN CONTACT IN THE NEW VALLEY GOVERNORATE, EGYPT

In this work, Mycobacterium bovis isolated and identified by microbiological culture and RT-PCR from emergency slaughtered aburden Angus cattle suffering from chronic mastitis and respiratory manifestations in private farm not perform tuberculin test in New Valley governorate, Egypt. Furthermore, other contact cattle, sheep and human in the farm examined by ELISA, found that 22.2% (4/18) cattle in the farm were positive, with complete absence of infection in the sheep and contact persons in the farm. The high percent of M. bovis was detected by RT-PCR (83.33%) followed by microbiological culture (72.22%) in slaughtered cattle. The highest percent of tubercles lesion observed in thoracic cavity followed by the lung then the udder. From our study we can concluded that, M. bovis isolated and identified from imported Aburden Angus cow in New Valley Governorate. Also, ELISA test need further evaluation before using as an exploratory test for diagnosis of BTB in animal and human.
Targeting I k B Kinase b /NF- k B Signaling in Human Prostate Cancer by a Novel I k B Kinase b Inhibitor CmpdA

NF- k B plays an important role in many types of cancer, including prostate cancer, but the role of the upstream kinase of NF- k B, IKK b , in prostate cancer has neither been fully documented nor are there any effective IKK b inhibitors used in clinical settings. Here, we have shown that IKK b activity is mediated by multiple kinases including IKK a in human prostate cancer cell lines that express activated IKK b . IHC analysis (IHC) of human prostate cancer tissue microarrays (TMA) demonstrates that phosphorylation of IKK a / b within its activation loop gradually increases in low to higher stage tumors as compared with normal tissue. The expression of cell proliferation and survival markers (Ki-67, Survivin) and epithelial-to-mesenchymal transition (EMT) markers (Slug, Snail), as well as cancer stem cell (CSC)-related transcription factors (Nanog, Sox2, Oct-4), also increase in parallel among the respective TMA samples analyzed. IKK b , but not NF- k B, is found to regulate Nanog, which, in turn, modulates the levelsofOct4,Sox2, Snail,andSlug, indicating anessential roleof IKK b in regulating CSCs and EMT. The novel IKK b inhibitor CmpdA inhibits constitutively activated IKK b /NF- k B signaling, leading to induction of apoptosis and inhibition of proliferation, migration, and stemness in these cells. CmpdA also signi ﬁ cantly inhibits tumor growth in xenografts without causing apparent in vivo toxicity. Furthermore, CmpdA and docetaxel act synergis-ticallytoinhibitproliferationofprostatecancercells.Theseresults indicate that IKK b plays a pivotal role in prostate cancer, and targeting IKK b , including in combination with docetaxel, may be a potentially useful strategy for treating advanced prostate cancer. b /NF- k B signaling, cell proliferation, and survival in PC3 cells. A, PC3 cells were treated with vehicle control or CmpdA (2 m mol/L) for 0.5to2hoursandphosphorylationstatusofIKK a / b ,I k B a ,andp65wasanalyzedbyWesternblotanalysis.B,PC3cellsweretreatedwithvehiclecontrolorCmpdA (2 to 10 m mol/L) for 0.5 to 48 hours and phosphorylation status of I k B a and p65 and levels of survivin and cleaved caspase-3 were analyzed by Western blot analysis. C, PC3 cellsweretransfected with NF- k B reporter and Renilla reporter control for 24 hours and treated with CmpdA for anadditional24 hours. Cellswere harvestedandanNF- k Breporterassaywasperformed.Theexperimentswererepeatedthreetimes. D,cellsweretreatedwithCmpdAfor48hoursandcellapoptosis was determined by measuring caspase activity. The results are representative of three independent experiments ( (cid:5) , P < 0.05; (cid:5)(cid:5) , P < 0.01; (cid:5)(cid:5)(cid:5) , P < 0.001). E, cells were treated with CmpdA for 48 hours and cell proliferation was determined by MTT assay. The results are representative of three independent experiments( (cid:5) , P < 0.05; (cid:5)(cid:5)(cid:5) , P < 0.001). F,apoptosiswasdeterminedvia ﬂ owcytometry.PC3cellswereculturedwithincreasingconcentrationsofCmpdA(2,5,and 10 m mol/L) for 72 Cells twice and
Sequence Homology Identification of Agonist Ligands with No Recognition Based on Peptide Scans Leads to the Cutting Edge: Predictable TCR Antigen

The potential of CD4 1 T cells for cross-recognition of self and foreign Ags has important implications for the understanding of thymic selection, lymphocyte survival, and the occurrence of autoimmune diseases. Here, we deﬁne the extensive ﬂexibility of Ag recognition for three human CD4 1 autoreactive T cell clones (TCC) by using ligands with single and multiple amino acid (aa) substitutions. Our results demonstrate that the spec-trum of tolerated ligands and the resulting stimulatory potency of peptides for a TCC can be predicted by the relative inﬂuence of each aa. Using this approach, we have identiﬁed stimulatory ligands not sharing a single aa in corresponding positions with the Ag used to establish the TCC. These results argue for an independent contribution of each aa in the peptide sequence to the afﬁnity of the MHC/peptide complex to the TCR. The Journal of Immunology, 1998, 160: 3631–3636.
THE MUSIC TEACHER AS CULTURAL MANAGER

The concept of teacher as cultural manager examines two teachers working in a difficult school context and compares their characteristics and behaviour in this context to theory derived from a larger ongoing study. The paper outlines a preliminary study that has been created to identify a framework of research strategies that are able to capture the characteristics of good practice in music teaching that promotes social inclusion. The study is philosophically founded upon Buber’s notion of inclusive relationships and explores a description of the characteristics of the teacher and community derived from a doctoral study into the meaning of music to children and the ways in which teachers give access to meaningful music making. The findings suggest that the teacher performs multiple roles to facilitate access to meaningful music experience through their relationship with community and the students. The role of teacher as builder of context and as a manager of the cultural life of students emerges as an important concept that requires further study in a larger investigation. characteristics of the teacher most valued by interviewees was up of the following actions and character: the teacher must be a maker, animateur, and a builder of psychological environment and creator of atmosphere and attitude; they must be personally encouraging, open and have an interest in what the children bring to the relationship and value their interest in music; and most importantly they must facilitate experience through imaginative curriculum. ”
Free Radical Scavenging Activity of Five Benzoic Acid Derivatives: A Theoretical M06-2X Study

The meta hybrid M06-2X functional combined with the 6-311++G(d,p) basis set are used to investigate the antioxidant activity of five benzoic acid derivatives naturally occurring in several plant food: gallic acid, para-hydroxybenzoic acid, protocatechuic acid, syringic acid and vanillic acid. To assess the antioxidant properties of these compounds, three mechanisms of free radicals scavenging are considered, namely the hydrogen atom transfer (HAT), stepwise electron transfer proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET) models. The effect of polar environments on the antioxidant power of these compounds is mimicked in water and methanol using the IEF-PCM solvation method. Our findings suggest that HAT is the preferred mechanistic pathway in gas phase, while SPLET is favoured in polar mediums. Protocatechuic and gallic acids are the most active in gas and polar solutions respectively, whereas PHBA is the least active in all the environments considered. The O-H group in para position of the carboxylic group (O3-H for GA and O2-H for the rest) is confirmed to be the most reactive site in gas phase, while in solution it is either of the O1-H site (for PHBA, PCA, SA and VA) or O4-H groups (for GA). The “HOMO-rule” of free radical scavenging ability does not seem to account properly for the antioxidant properties of this set of chemicals.
Computational Investigation of Unsteady Low-Reynolds Number Aerodynamics for Micro Air Vehicles

Abstract : A Navier-Stokes equation solver is utilized to investigate the aerodynamics of a flapping airfoil. The roles of plunging and pitching amplitude and frequency, and Strouhal number are studied. For a NACA0012 airfoil at zero geometric angle of attack, chord Reynolds number of 20,000 and at a given plunging frequency, either drag or thrust is produced, depending on the plunging amplitude. When drag is produced, the viscous force dominates the total drag with decreasing influence as the plunging amplitude increases. At the considered plunging amplitude (from 0.0125c to 0.075c), flow history has more influence than the kinematic angle of attack in determining lift. For an airfoil experiencing combined plunge and pitch motion, both thrust and input power increase with the Strouhal number (within the range of 0.03 to 0.5). For the case studied, the thrust is induced by the lift, which follows approximately the curve of kinematic angle of attack. Leading edge vortex moves downstream and interacts with the trailing edge vortex. The impact of a gust on a stationary and flapping airfoil is also studied.
Cytomegalovirus Infection Immunodominance in Murine Does Not Alter Acute or Chronic CD8 T Cell Viral Interference with Antigen Presentation

Both human CMV and murine CMV (MCMV) elicit large CD8 T cell responses, despite the potent effects of viral genes that interfere with the MHC class I (MHC I) pathway of Ag presentation. To investigate the impact of immune evasion on CD8 T cell priming, we infected mice with wild-type (wt) MCMV or a mutant lacking its MHC I immune evasion genes, (cid:1) m4 (cid:2) m6 (cid:2) m152 MCMV. In acute infection, the two viruses elicited a CD8 T cell response to 26 peptide epitopes that was virtually identical in total size, kinetics, and immunodominance hierarchy. This occurred despite results demonstrating that primary DCs are susceptible to the effects of MCMV’s MHC I immune evasion genes. Eight months later, responses to both wt and mutant MCMV displayed the same CD8 T cell “memory inﬂation” and altered immunodominance that characterize the transition to chronic MCMV infection in C57BL/6 mice. Taken together, these ﬁndings suggest either that cross-priming dominates over direct CD8 T cell priming in both acute and chronic MCMV infection, or else that the MHC I immune evasion genes of MCMV are unable to alter direct CD8 T cell priming in vivo. At 2 years postinfection, differences in CD8 T cell immunodominance emerged between individual mice, but on average there were only slight differences between wt and mutant virus infections. Overall, the data indicate that the presence or absence of MHC I immune evasion genes has remarkably little impact on the size or speciﬁcity of the MCMV-speciﬁc CD8 T cell response over an entire lifetime of infection. The Journal of Immunology, 2007, 178: 7235–7241.
The Typology of Resultative Constructions

Spray coating apparatus featuring an improved solenoid valve construction in which response time of the valve actuation is improved by a free-traveling armature. The armature which is unrestrained by spring or other means has an annular shoulder portion which is engageable with an enlarged head portion of the pilot member of the valve. When the pilot is in its seated position, the dimensions of the valve are such that the armature must travel a short distance before its shoulder will impact against the pilot head thus allowing kinetic energy to build up as the armature travel is initiated by coil energization which enables the armature to effectively snap open the pilot upon impact despite spring and high fluid pressure resistance. A response time on the order of 4 to 8 milliseconds is enabled by the elimination of mechanical characteristics in the valve which would otherwise tend to limit the drive characteristics of the circuitry and is further aided by the ratio of travel of armature to pilot between full opened and full closed position which enables the necessary kinetic energy build up in the armature for opening and permits the pilot to close independently of the return of the armature to its unactivated position.
Genetic Analysis to Select Good Combiners for TYLCV-Tolerance and Yield Components in Tomato

As an attempt to develop high-yielding and TYLCV-tolerant hybrids, this study was conducted using TYLCV-tolerant inbred lines F8: 802-5 (P 1 ); F8: 802-21 (P 2 ) and selection of CLN3498E (P 3 ) and TYLCV-susceptible cvs Ace 55VF (P 4 ), Super Strain B (P 5 ) and Castlerock (P 6 ). A line × tester mating system was carried out under greenhouse conditions through the 2012 winter planting to produce tolerant × susceptible hybrids. Nine F 1 hybrids and their parents were evaluated for TYLCV tolerance, yield and fruit quality under natural infection of TYLCV by whitefly-mediated virus inoculations under field conditions during the 2013 and 2014 fall plantings. Mid-parent hterosis (H), heterobeltiosis (BPH), potence ratio (P), and combining ability effects were estimated for the evaluated traits. The variances due to combining abilities showed that additive gene action played the predominant role in controlling TYLCV-tolerance and yield traits. The hybrids of parent P 1 , in addition to P 2 × P 4 exhibited the maximum H and BPH for early (EY) and total yield (TY)/plant under TYLCV-infection. The hybrids of P 1 were exhibited the maximum negative significant H of TYLCV mean score. TYLCV-tolerant parent P 1 was a good combiner for TYLCV mean score, EY/plant and TY/plant traits, while, TYLCV-susceptible parent P 4 was a good combiner for each of TYLCV-mean score, EY/plant, TY/plant, average fruit weight (AFW), and fruit TSS content traits. The TYLCV-tolerant cross P 2 × P 4 was a good combination for TYLCV mean score, TY/plant, AFW, fruit firmness, and fruit TSS content traits, while TYLCV-tolerant cross P 1 × P 4 was a good combination for TYLCV mean score, EY/plant, TY/plant and fruit titarable acidity content traits.
A Cross-Sectional Study to Analyze the Association between Anthropometric Measurements and Academic Performance among I Year Indian Medical Students

Objective: Relationship between overweight and academic performance in children and adolescents has been studied, but the results are inconclusive. It is known that medical profession demands immense effort and students are more prone to develop stress which might affect their body weight and hence their studies. Therefore, this study aims to evaluate the association between anthropometry and academic performance of I year medical students. Materials and methods: Anthropometric measurements like height, weight, waist and hip circumference of 100 I year medical students were taken. They were subdivided based on their BMI as underweight, normal and overweight subgroups. Academic performance was assessed based on their marks obtained for physiology theory exam which was done during their course of study. Results: There is a significant negative association between anthropometric measurements and academic performance (Pearson correlation, p<0.05). There was no significant association between anthropometry and academic performance when adjusted for gender (logistic regression). Female students performed better than males, showing a significant association between gender and academic performance when controlled for BMI (logistic regression, p<0.001). Conclusion: Our present study found that there is no association between academic performance and anthropometric measurements. Female students performed better when compared to male students. Studies with larger sample size, adjusting for all confounding factors are recommended to confirm the finding.
Ontogeny of the Production of an Estrogen-Regulated Eosinophil Chemotactic Factor in the Rat Uterus1

The ontogeny of an estrogen-induced eosinophil chemotactic activity in the uterus after estrogen administration and its regulation by progesterone was studied in neonatal rats at 3, 7, 10, and 13 days of age. These results were compared with the increase in peroxidase activity and the secretion of complement component C3 by the uterus. No chemotactic activity was observed in animals younger than 14 days, and after this age the estrogen regulation of the response was also prevented by the co-administration of progesterone. The secretion of complement C3 appeared earlier, at 10 days of age. It was also observed that the uterus of 3-7-day-old rats responded to estrogen by increasing the secretion of two proteins of 36 and 110 kDa. No further regulation or synthesis was observed with increasing age for these two proteins.
A Study of Red Blood Cell Indices among Covid 19 Individuals in Tertiary Care Triage Centre

Background: SARS-CoV-2 infection is characterized by the development and progression of inflammatoryresponses. The exploration of prognostic predictors for patients with COVID-19 is vital for prompt clinicalintervention. Our study aims to explore the predictive value of hematological parameters in categorizationof patients with COVID-19.We aimed to investigate associations between hematological parameters anddisease severity in patients with SARS-CoV-2infection.The red blood cell distribution width (RDW),an indicator of anisocytosis has emerged as a potential tool for risk stratification of critically ill patients.Materials and Methods: Retrospective study after getting approval from Institutional ethics committeewas performed with data obtained from triage OPD in Chengalpattu Medical College & Hospital. Thedemographic, clinical, laboratory profile of COVID 19 positive patients who attended Triage OPD for aperiod of one month were collected. 3000 RT-PCR confirmed COVID positive patients of age group 20to 70 years of both genders were included in the study. COVID 19 positive paediatric cases, antenatal andpostnatal mothers, postoperative cases and sick cases admitted in COVID ICU were excluded from thestudy. Symptoms, associated co-morbidities and severity of COVID 19 were tabulated. Complete BloodCount measured by Automated Sysmex Analyser at the time of reporting to triage was noted. Red bloodcell indices were analysed using SPSS 21.0 version. Results: There was statistically significant increase inRDW and decrease in MCV among patients with co-morbidity and severe illness compared to those withmild disease. There is no statistically significant difference in Red blood cell indices between patients withand without symptoms and patients without co-morbidities. Conclusion: RDW was found to be a screeningtool to identify patients with severe COVID-19 and the results of this study suggest that RDW should be partof routine laboratory assessment and monitoring of COVID-19.
Identity and Performance in Margaret Atwood Novel Cat’s Eye

Studies of gender identity show gender and sex are not natural but they are the products of working of power in societies such as institutions, discourse, and practices. One of the contributions of recent gender studies is to question the instability of masculine and feminine gender identity. This study is an application of Judith Butler concept ‘performative’ on Margaret Atwood novel Cat’s Eye(1988) relying on Butler’s concepts of identity and performance. The novel deals with gender performativity and the role of patriarchal society played on the female characters. Throughout her female protagonists, Atwood raises the question of woman’s place in a patriarchal society. The premise of this study is not only to determine the extent to which gender performativity determines the character’s identity but also to illustrate how gender identity is unstable and constructed socially and culturally.
Molecular and immunological study for detection of IL-6 in men infected with Trichomonas vaginalis parasite in Al-Najaf province; Iraq

The aim of this research was to diagnosis of Trichomonas vaginalis by use PCR technique and evaluate interleukin-6 (IL-6) in men infected with Trichomonas vaginalis; urine and blood specimens were collected from 85 men whom have visited the department of infertility at Al-Sadder medical city, Al-Zahra Hospital in Najaf Province during the period from June till October, 2012. Twenty healthy looking age matched men taken to serum tubes and serum was separated. Serum was used for evolution of the IL-6.The IL-6 was evaluated in serum using ELISA technique . Trichomonas vaginalis was isolated from 15 men with a prevalence rate 17.64% by using PCR technique. The results revealed a significant increase in IL-6 in men infected with Trichomonas vaginalis in compared to control group and the PCR is accurate method used in diagnosis of Trichomonas vaginalis parasite.