Miracle-dz/UniFAR-FTUs huggingface dataset:
Wine bottle closures: physical characteristics and effect on composition and sensory properties of a Semillon wine 1. Performance up to 20 months post‐bottling

A Semillon wine was bottled using 14 different closures: a screw-cap type, two grades of conventional natural cork, two 'technical cork' closures (natural cork with a synthetic component), and 9 closures manufactured from synthetic polymer material. Closure performance was evaluated for physical aspects (e.g. extraction force and energy, change in closure diameter, and ease of closure reinsertion), and for wine composition and sensory properties. Wine under the screw cap closure retained the greatest concentration of sulfur dioxide (SO2) and ascorbic acid and had the slowest rate of browning. For other closures the trend of SO2 loss relative to the screw cap closure was apparent from an early stage of testing, and was most evident in the group of synthetic closures, intermediate in the conventional corks, and least evident in the technical cork closures. The loss of SO2 was in general highly correlated with an increase in wine browning (OD420) and the concentration of SO2 in the wine at six months was a strong predictor of future browning in the wine, particularly after eighteen months. Neither the concentration of dissolved oxygen at bottling (0.6-3.1 mg/L), nor the physical closure measures were predictors of future browning. For several closures upright storage tended to accelerate loss of SO2 from the wine, but in many cases this effect was marginal. The closures differed widely in regard to physical characteristics, and in general synthetic corks appeared least 'consumer-friendly' in terms of extraction forces, energies, and ease of closure re-insertion, but there was a trend for natural cork closures to exhibit larger variability in physical characteristics than technical cork and synthetic closures. Sensory analysis indicated large differences in wine flavour properties, with closures which tended to result in the best retention of free SO2 having wine sensory scores for 'citrus' that were generally high whilst scores for the attributes 'developed'/'oxidised' were low. The situation was reversed for wine under closures that performed poorly in the retention of free SO2. It was found that below a critical level of free SO2 remaining in the wine, closures exhibited substantially higher 'oxidised' aroma. Whilst trichloroanisole-type (TCA) taint was a noticeable problem for some cork and technical cork closures, any plastic-type taint appeared not to be a problem with most synthetic closures.
Insights into the Action Mechanism of the Antimicrobial Peptide Lasioglossin III

Lasioglossin III (LL-III) is a cationic antimicrobial peptide derived from the venom of the eusocial bee Lasioglossum laticeps. LL-III is extremely toxic to both Gram-positive and Gram-negative bacteria, and it exhibits antifungal as well as antitumor activity. Moreover, it shows low hemolytic activity, and it has almost no toxic effects on eukaryotic cells. However, the molecular basis of the LL-III mechanism of action is still unclear. In this study, we characterized by means of calorimetric (DSC) and spectroscopic (CD, fluorescence) techniques its interaction with liposomes composed of a mixture of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-rac-phosphoglycerol (POPG) lipids as a model of the negatively charged membrane of pathogens. For comparison, the interaction of LL-III with the uncharged POPC liposomes was also studied. Our data showed that LL-III preferentially interacted with anionic lipids in the POPC/POPG liposomes and induces the formation of lipid domains. Furthermore, the leakage experiments showed that the peptide could permeabilize the membrane. Interestingly, our DSC results showed that the peptide-membrane interaction occurs in a non-disruptive manner, indicating an intracellular targeting mode of action for this peptide. Consistent with this hypothesis, our gel-retardation assay experiments showed that LL-III could interact with plasmid DNA, suggesting a possible intracellular target.
Foraging habitat of North Atlantic right whales has declined in the Gulf of St. Lawrence, Canada, and may be insufficient for successful reproduction

Climate-induced changes in calanoid copepod (Calanus spp.) availability in traditional feeding areas might explain why a large proportion of the North Atlantic right whale Eubalaena glacialis population has fed in the Gulf of St. Lawrence (Canada) in recent years. However, little is known about the distribution of copepods in the gulf, and whether their abundance is sufficient to energetically sustain right whales. We used a mechanistic modelling approach to predict areas within the gulf that have foraging potential for adult female right whales, based on the annual energetic needs of resting, pregnant and lactating females, and their theoretical prey density requirements. We identified suitable foraging areas for right whales by coupling a foraging bioenergetics model with a 12 yr data set (2006−2017) describing the abundance and 3-dimensional distribution of late-stage Calanus spp. in the gulf. Prey densities in the southern gulf (from Shediac Valley to the Magdalen Islands) supported all 3 reproductive states in most (≥6) years. However, foraging habitat became progressively sparse in the southern gulf over time, with noticeably less suitable habitat available after 2014. Few other potentially suitable foraging areas were identified elsewhere in the gulf. Overall, the availability of foraging habitat in the gulf varied considerably between years, and was higher for resting females than for pregnant and lactating females. Our findings are consistent with the recent low calving rates, and indicate that prey biomass in the Gulf of St. Lawrence may be insufficient in most years to support successful reproduction of North Atlantic right whales.
Dynamic Supply Voltage Control for PA Output Power Correction Under Variable Loading Scenarios

This article presents an automatic system that is able to dynamically restore the output power capability of a power amplifier (PA) under variable loading scenarios. This is accomplished by dynamically adapting the supply voltage, <inline-formula> <tex-math notation="LaTeX">${V_{\mathrm{ DD}}}$ </tex-math></inline-formula>, of the PA according to the developed theoretical model. To dynamically vary <inline-formula> <tex-math notation="LaTeX">${V_{\mathrm{ DD}}}$ </tex-math></inline-formula>, a GaN dc–dc converter, based on the commercial EPC 9067 Demo Board, was used. The load is measured using an impedance meter, which is based on the slotted line principle and was specifically designed for low insertion loss. This impedance meter also generates a load-dependent pulsewidth modulated signal that controls the dc–dc converter switching, regulating <inline-formula> <tex-math notation="LaTeX">${V_{\mathrm{ DD}}}$ </tex-math></inline-formula>. The prototype was designed for 3.55 GHz and tested with CW and modulated signal excitations, being able to compensate the output power degradation under variable loading conditions inside a 2.1 voltage standing wave ratio circle. For a constant gain compression level, the average efficiency degradation over the tested range of impedances is less than 5%, and the average power improvement is 0.7 dB. The worst case measured output power of the PA is compensated from 37.0 to 39.9 dBm, which corresponds to a 2.9 dB improvement. Using a modulated signal excitation, the peak envelope power, which is compressed by almost 3 dB without <inline-formula> <tex-math notation="LaTeX">${V_{\mathrm{ DD}}}$ </tex-math></inline-formula> compensation, is restored, and the average output power is improved by 0.6 dB. The system can track the load and adjust <inline-formula> <tex-math notation="LaTeX">${V_{\mathrm{ DD}}}$ </tex-math></inline-formula> with a worst case step-up delay of 25 ms.
On practical application of Zubov’s optimal damping concept

This article presents some new ideas connected to nonlinear and nonautonomous control laws based on the application of an optimization approach. There is an essential connection between practical demands and the functionals to be minimized. This connection is at the heart of the proposed methods. The discussion is focused on the optimal damping concept first proposed by V. I. Zubov in the early 1960’s. Significant attention is paid to various modern aspects of the optimal damping theory’s practical implementation. Emphasis is given to the specific choice of the functional to be damped to provide the desirable stability and performance features of a closed-loop system. The applicability and effectiveness of the proposed approach are confirmed by an illustrative numerical example.
Interleukin-2 level for normal people and COVID-19 Infection: is it our concern is COVID-19 Infection or Inreleukin-2 level before the infection?

The newly discovered Coronavirus severe acute respiratory distress syndrome virus-19 (SARAS-COV-2, COVID-19) has become a pandemic issue across the globe Until now, many investigations are taking place to look for specific, safe, and potent anti-viral agents Upon transmission and entry into the human body, SARS-COV-2 Trigger multiple external players to be involved in the protection against the viral infection These include Masks, Gloves, Sanitizing and social distancing On the other hand, multiple internal body players to be involved in the protection against the viral infection These include Angiotensin converting enzyme inhibitors or (ACEI) or Angiotensin receptor blockers or (ARB) Also, immune players to be involved in the fight against the viral infection These include Vaccines, plasma from the Recovered patients and cellular immune players such as B, T and natural killer (NK) Cells, as well as the soluble Cytokines and Chemokines In this review, we will propose the best way to protect ourselves against COVID-19 infection using Interleukin-2, based on evidences we have
SHP1 Decreases Level of P-STAT3 (Ser727) and Inhibits Proliferation and Migration of Pancreatic Cancer Cells.

PURPOSE To identify the direct effects and functional mechanisms of SHP1, plus its relationship with STAT3 in pancreatic cancer. METHODS Immunohistochemistry and Western blot assays were used to test SHP1 expression in pancreatic cancer. The functions of SHP1 in pancreatic cancer cells were analyzed by cell viability, colony formation, flow cytometric analysis of apoptosis, migration and invasion assays. Co-immunoprecipitation, combined with shotgun mass spectrometry, verified the direct or indirect interactions with JAK1 and p-STAT3(Ser727). Non-labeling and quantitative proteomics analysis evaluated the effect of SHP1 on protein expression levels. PRM phosphorylation modification of quantitative proteomics analysis confirmed p-STAT3(Ser727) levels. RESULTS SHP1 was missing or weakly expressed in human pancreatic ductal adenocarcinoma tissues and cells: PANC-1, AsPC-1, BxPC-3, and SW1990. SHP1 inhibited cell proliferation and migration. SHP1 had a slight effect on the protein expression level of PANC-1 cells. The level of p-STAT3(Ser727) was decreased by SHP1 at 0.53 multiple. Co-IP analysis revealed no direct or indirect interactions between SHP1and p-STAT3(Ser727) in protein complex patterns. CONCLUSION These results suggest that SHP1 negatively regulate pancreatic cancer cells progression. It inhibits STAT3 activation by decreasing STAT3 phosphorylation at serine 727.
Spectrochemical Analysis of Metal Elements Electrodeposited from Water Samples by Laser-Induced Shock Wave Plasma Spectroscopy

We have succeeded in applying laser-induced shockwave plasma spectroscopy (LISPS) to the problem of the detection and analysis of metal elements deposited from water samples by means of electrolysis. It is shown that metal elements are generally deposited in the form of a thin film on the electrode surface, while the electrode also conveniently serves as a subtarget for the relatively soft metal film, thereby providing the necessary conditions for the generation of shockwave plasma, which is favorable for highly sensitive spectrochemical analysis. It is shown that the detection sensitivity of this method reaches its highest value at low surrounding air pressure of around 1 torr. The lowest detection limit attained for various metal elements investigated in this experiment varies from around ten to a few tens of ppb. This limit can be readily improved upon by incorporating an optical multichannel analyzer into the detection system. We have thus presented a promising method for the realization of a compact mobile monitoring system for the accurate control of water and soil quality.
Evolution of the Role of Radiotherapy for Anal Cancer

Simple Summary Prior to the 1980s, primary management of localized anal cancer was surgery. Dr. Norman Nigro and colleagues found that neoadjuvant chemoradiotherapy with 5-fluorouracil and mitomycin C afforded complete response, obviating the need for surgery upfront. Advancements in radiotherapy delivery using intensity-modulated radiation therapy (IMRT) and image-guided radiation have resulted in reductions in radiation-associated adverse effects, allowing for the delivery of greater doses of radiation. Ongoing prospective trials are attempting to improve IMRT-based treatment of locally advanced disease with efforts to increase personalized treatment. Trials of newer modalities such as proton therapy are underway. In this review, we present the evolution of radiotherapy for anal cancer and describe recent advances to contextualize ongoing studies and inform future directions in efforts to mitigate treatment toxicities, further personalize treatment, and improve oncologic outcomes. Abstract Prior to the 1980s, the primary management of localized anal cancer was surgical resection. Dr. Norman Nigro and colleagues introduced neoadjuvant chemoradiotherapy prior to abdominoperineal resection. Chemoradiotherapy 5-fluorouracil and mitomycin C afforded patients complete pathologic response and obviated the need for upfront surgery. More recent studies have attempted to alter or exclude chemotherapy used in the Nigro regimen to mitigate toxicity, often with worse outcomes. Reductions in acute adverse effects have been associated with marked advancements in radiotherapy delivery using intensity-modulated radiation therapy (IMRT) and image-guidance radiation delivery, resulting in increased tolerance to greater radiation doses. Ongoing trials are attempting to improve IMRT-based treatment of locally advanced disease with efforts to increase personalized treatment. Studies are also examining the role of newer treatment modalities such as proton therapy in treating anal cancer. Here we review the evolution of radiotherapy for anal cancer and describe recent advances. We also elaborate on radiotherapy’s role in locally persistent or recurrent anal cancer.
Seawater Reverse Osmosis Brines as a New Salt Source for the Chlor-Alkali Industry: Integration of NaCl Concentration by Electrodialysis

Seawater RO brines have been identified as an alternative to common NaCl sources for the chlor-alkali industry. Electrodialysis (ED) has been evaluated as a preliminary step of NaCl concentration for these brines. Experimental results showed that ED was an effective concentration technology, where values up to 252 gNaCl L−1 were reached at 0.3-0.4 kA m −2 with a power consumption of approx. 0.20-0.30 kWh kg−1 NaCl. As the membranes used (Neosepta CIMS and ACS) were mainly selective for univalent ions, polyvalent ions were partially removed from the brine, benefiting its reuse. NaCl concentrated solutions are to be used as feed brine in the chlor-alkali industry after a purification step.
Efficiency of capping contaminated sediments in situ. 2. Mathematics of diffusion-adsorption in the capping layer

Simple analytical models for hydrophobic organic pollutant release from a contaminated sediment capped (covered) with a clean material are presented. Three situations are considered: a base case of uncapped contaminated sediment, a case associated with high sediment contamination levels with essentially constant contaminated layer pore-water concentration, and a more general case in which the leaching of the pollutant from the contaminated sediment layer is considered. The model results are compared to experimental data from laboratory bench-scale simulators. Both models show generally good agreement with the experimentally observed fluxes, indicating that the fundamental transport mechanisms are well understood
Synthesis of Piperidine Nucleosides as Conformationally Restricted Immucillin Mimics

The de novo synthesis of piperidine nucleosides from our homologating agent 5,6-dihydro-1,4-dithiin is herein reported. The structure and conformation of nucleosides were conceived to faithfully resemble the well-known nucleoside drugs Immucillins H and A in their bioactive conformation. NMR analysis of the synthesized compounds confirmed that they adopt an iminosugar conformation bearing the nucleobases and the hydroxyl groups in the appropriate orientation.
Response of chickpea (Cicer arietinum L.) to plant growth regulators

A field experiment was conducted during rabi season of 2015-16 on clayey soil at Instructional farm, JAU, Junagadh to study the response of chickpea (Cicer arietinum L.) to plant growth regulators in randomised block design with three replications.The results revealed that higher values of growth parameters viz., plant height, number of branches per plant and yield attributes viz., number of pods per plant along with seed and stover yields were recorded under GA3 100 ppm at flowering stage, kinetin 10 ppm at flowering stage, GA3 50 ppm at flowering stage and kinetin 5 ppm at flowering stage over control. The highest net return of ₹ 74381 ha-1 was realized with kinetin 10 ppm at flowering stage followed by the treatments T5 (GA3 100 ppm at flowering stage), T3 (GA3 50 ppm at flowering stage) and T7 (kinetin 5 ppm at flowering stage) by recording net return of 73113, 70355 and 68004 ha-1 respectively. However, maximum BCR of 3.51 and 3.31 was obtained with the treatment T9 kinetin 10 ppm at flowering stage. It could be concluded that spraying of plant growth regulators kinetin or GA3 at the time of flowering stage gave higher yield net return of chickpea under South Saurashtra Agro-climatic conditions.
Bioprospecting Fluorescent Plant Growth Regulators from Arabidopsis to Vegetable Crops

The phytohormone auxin is involved in almost every process of a plant’s life, from germination to plant development. Nowadays, auxin research connects synthetic chemistry, plant biology and computational chemistry in order to develop innovative and safe compounds to be used in sustainable agricultural practice. In this framework, we developed new fluorescent compounds, ethanolammonium p-aminobenzoate (HEA-pABA) and p-nitrobenzoate (HEA-pNBA), and investigated their auxin-like behavior on two main commercial vegetables cultivated in Europe, cucumber (Cucumis sativus) and tomato (Solanum lycopersicum), in comparison to the model plant Arabidopsis (Arabidopsis thaliana). Moreover, the binding modes and affinities of two organic salts in relation to the natural auxin indole-3-acetic acid (IAA) into TIR1 auxin receptor were investigated by computational approaches (homology modeling and molecular docking). Both experimental and theoretical results highlight HEA-pABA as a fluorescent compound with auxin-like activity both in Arabidopsis and the commercial cucumber and tomato. Therefore, alkanolammonium benzoates have a great potential as promising sustainable plant growth stimulators to be efficiently used in vegetable crops.
HOT AIR AND MICROWAVE DRYING OF ONIONS: A COMPARATIVE STUDY

ABSTRACT This comparative study of conventional (hot air) drying and microwave drying of the onion was carried out on a hot air pilot plant drier for conventional drying where all characteristics (temperature, humidity, and velocity) could be adjusted and controlled. A data logger connected to a computer captured all data. And for microwave drying, a drying tunnel Fitted with a forward/backward movement was used. Mass loss and product surface temperature were monitored for both processing. Factors controlled where: frequency of movement, microwave power, air extraction rate. Other elements included shape (slices/pieces) and variety of product Drying duration and maximum drying rate constituted comparative criterion for the processes. Quality was measured by the reducing sugars and polyfructans content. Analysis of variance for the microwave drying process suggests that the effective factors were microwave power followed by onion variety and shape respectively. For quality criterion by far the most effecti.
Determinant of Tax Compliance Intention in Java-Indonesia:

Tax reform in Indonesia changed the taxation system from an official assessment system to a self-assessment system. This means that taxpayers are required to calculate, pay and report their own taxes. However, that the self-assessment system, many taxpayers are not transparent in their tax reporting. This shows that low awareness of the taxpayers to pay taxes so the tax compliance in Indonesia is still low. This study purpose to examine the factors that influence intention in tax compliance from psychology perspective. This study is a replication and models development of Theory of Reasoned Action (TRA) from previous studies. The study model is validated using the data collected from 136 respondents which is individual tax payers in Java who have got tax registration number (NPWP) and who have report the annual tax return or SPT in Java Indonesia. The data is analysed using Smart Partial Least Square (PLS). The result of analysis for this study shows that the construct attitude and tax system influence the intention in tax compliance. However, that subjective norms did not influence the intention in tax compliance. The implication for this study is relevant to the Directorate General of Tax to consider factor of attitude and tax system to increase tax compliance intension in Indonesia. Keywords—theory of reasoned action, tax compliance, intention
High amplitude wave propagation in collapsible tubes. II: Forerunners and high amplitude waves

It is shown that, under certain circumstances, a pressure wave of large amplitude which propagates in a fluid, inside a deformable viscoelastic tube initially inflated or collapsed, can present the behaviour of a shock wave. The characteristic time and length of formation for such a shock like wave can be computed from the method of characteristics if the dynamic rheological law of the tube is known. The principal feature of such a shock wave propagation inside an initially collapsed tube is the presence of wavelets on the wave front. The dispersion relation of such wavelets, experimentally obtained from the wall displacements measurements, has been theoretically interpreted on the basis of dynamical effects dominated by the longitudinal tension of the tube On essaie de mettre en evidence la relation entre la propagation d'une onde de grande amplitude dans un tube collabable et les proprietes mecaniques du tube. La caracteristique essentielle du front d'onde de surpression, dans le cas d'un tube initialement partiellement collabe, est la presence d'ondelettes se propageant en precurseur du front d'onde principal. La propagation de ces ondes peut etre caracterisee par une equation de dispersion dont on donne une interpretation theorique