Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study

Hepatocellular carcinoma (HCC) is a highly prevalent form of liver cancer. Sorafenib is the first-line treatment for patients who are not eligible for surgical procedures. Still, it causes important adverse effects, does not provide symptoms relief, and is marketed at expensive costs. Here we investigated the effectiveness of imatinib, sunitinib, and bortezomib against an in vitro model of HCC. These drugs are less expensive than Sorafenib and are approved for other malignant neoplasia. The drugs were tested as free and liposome-entrapped forms against HepG2 cells. Liposomes were prepared without using organic solvents and were tested for physicochemical stability. Entrapment efficiency was determined by spectrophotometric methods. Liposomes' average size was 238±33 nm, with an average entrapment efficiency of 34.3%. All drugs significantly decreased the viability of HepG2 cells in their free form and liposome-entrapped forms compared to the control. In spite of the low entrapment efficiency, no organic solvent was used in liposomes preparation, and cell viability values after 18h treatments with liposome-entrapped drugs were only surpassed by the highest concentration of free drugs. Our data open doors for more studies to assess the safety of the liposomes in vivo.
Lateral Alveolar Ridge Augmentation with Autologous Dentin of Periodontally Compromised Teeth: A Retrospective Study

Tooth shell technique (TST) using autologous dentine is possible with lateral ridge augmentation while avoiding a donor region. This study aimed to clarify whether the use of periodontally compromised teeth (PCT) leads to similar results compared to non-periodontally compromised teeth (NPCT). In this retrospective study, the dentin matrix of 41 patients (PCT: n = 19 with 29 implants; NPCT: n = 22, with 29 implants) was used for TST. All cases were re-examined. Outcome parameters were biological complications, horizontal hard tissue loss, osseointegration, and the integrity of the buccal lamella. Only in one case in the PCT group, a graft was lost. In three cases, minor complications were identified, including two cases of wound dehiscence and one case of inflammation with suppuration (PCT: n = 1, NPCT: n = 3). All implants, except the one with the severe complication, were osseointegrated and the integrity of the buccal bone lamella was preserved. Mean difference of the resorption of the crestal width and the buccal lamella did not differ statistically between the two groups. TST using PCT showed results comparable to those of NPCT in terms of complications and graft resorption. Processed dentin matrix from PCT can be used and applied with predictable results for bone grafting, utilizing TST.
Preparation and Adsorption Properties of MCM-41 with Novel Gemini Ionic Liquid Surfactants as Template

A mesoporous molecular sieve was prepared by the hydrothermal synthesis method with symmetric Gemini surfactant 1,3-bis(hexadecyldimethylammonio)-propane dibromide, symmetric Gemini ionic liquid surfactant 1,3-bis(3-hexadecylimidazolium-1-yl) propane dibromide and self-designed asymmetric Gemini ionic liquid surfactant 1-(3-(hexadecyldimethylammonio)prop-1-yl)-3-hexadecylimidazolium dibromide as the template agent. The structure characterization results for mesoporous molecular sieves show that the material possesses a hexagonal pore structure with uniform channels. The mesoporous silica that was synthesized with self-designed asymmetric Gemini ionic liquid surfactant as the template agent possesses the largest surface area and its pore size and specific surface area are, respectively, 3.28 nm and 879.37 m2/g. The adsorption properties of the prepared MCM-41 for crystal violet were investigated, and the adsorption thermodynamics and kinetics were investigated. The results show that adsorption equilibrium can be reached under pH = 9 and 35 °C for 50 min, and the quantity of adsorption can reach up to 464.21 mg/g. The adsorption process belongs to Langmuir isothermal adsorption, conforming to second-order adsorption kinetics, and the adsorption process is an endothermic process.
Green Synthesis and Pinning Behavior of Fe-Doped CuO/Cu2O/Cu4O3 Nanocomposites

Egg white-induced auto combustion has been used to synthesize undoped and Fe-doped CuO/Cu2O/Cu4O3 nanocomposites in a soft, secure, and one-pot procedure. X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR) investigations have been used to identify functional groups and the structural properties of crystalline phases present in the as-synthesized composites. Scanning Electron Microscopy/Energy Dispersive Spectrometry (SEM/EDS) elemental mapping analyses and Transmission Electron Microscopy (TEM) techniques were used to explore the morphological and compositional properties of these composites. N2-adsorption/desorption isotherm models have been used to examine the surface variables of the as-prepared systems. Based on the Vibrating Sample Magnetometer (VSM) technique, the magnetic properties of various copper-based nanocomposites were detected due to being Fe-doped. XRD results showed that the undoped system was composed of CuO as a major phase with Cu2O and Cu4O3 as second phases that gradually disappeared by increasing the dopant content. The crystalline phase’s crystallographic properties were determined. The average particle size was reduced when the synthesized systems were doped with Fe. The construction of porous and polycrystalline nanocomposites involving Cu, Fe, O, and C components was confirmed by SEM/EDS and TEM measurements. In terms of the increase in magnetization of the as-manufactured nanocomposites due to Fe-doping, oxygen vacancies at the surface/or interfacial of nanoparticles, while also domain wall pinning mechanisms, were investigated. Finally, employing the investigated production process, Fe doping of CuO/Cu2O/Cu4O3 nanocomposite resulted in the development of a single phase (CuO) exhibiting “pinned” type magnetization. This is the first publication to show that CuO/Cu2O/Cu4O3.
Silage Quality and Output of Different Maize–Soybean Strip Intercropping Patterns

Intercropping improves land-use efficiency under conditions of limited land and resources, but no information is currently available pertaining to land-use efficiency and silage quality based on whole-plant utilization. Therefore, a two-year field experiment was conducted with the following conditions: three maize–soybean strip intercropping patterns, comprising two maize rows along with two, three, or four soybean rows (2M2S, 2M3S, and 2M4S, respectively); and two sole cropping patterns of maize (SM) and soybean (SS). The aim was to evaluate the biomass yield and silage quality under each condition. Our results showed that all SIPs had a land equivalent ratio (LER) of over 1.6 based on both fresh and dry matter yield, and a higher whole plant yield, compared to sole cropping. Specifically, 2M3S exhibited the highest whole crop dry matter LER (1.8–1.9) and yield (24.6–27.2 t ha−1) compared to SM and SS (20.88–21.49 and 3.48–4.79 t ha−1, respectively). Maize–soybean mixed silages also showed better fermentation quality with higher lactic acid content (1–3%) and lower ammonia-N content (2–8%) compared to SS silages, and higher crude protein content (1–1.5%) with lower ammonia-N content (1–2%) compared to SM silage. Among the intercropping patterns, 2M3S had the highest fermentation quality index V-score (92–95). Consequently, maize–soybean strip intercropping improved silage quality and biomass yield, with 2M3S being recommended, due to its highest LER and biomass yield, and most optimal silage quality.
Cutworms (Lepidoptera: Noctuidae) in central Brazil Savanna: temporal distribution and association of species abundance with climatic and meteorological factors

Population dynamics studies make it possible to predict the response of species to seasonal and inter‐annual climatic phenomena in hypothetical scenarios of climatic abnormality. However, long‐term studies on the temporal distribution and abundances of species are still scarce in the literature, including for species of agricultural importance. The present study aimed to bridge this gap through monthly collection events of species of cutworms (species of Agrotis and Feltia) across eight crop seasons (from July 2012 to June 2020) in the Brazilian Savanna (Cerrado). This biome is characterised by an irregular distribution of rainfall during a normal year, including two well‐defined periods of dry and rainy seasons. Only five species of cutworms were recorded: Agrotis ipsilon, Agrotis canities, Feltia repleta, Feltia submontana and Feltia subterranea, all widely distributed across South America. Except for F. submontana, occurring only in the autumn, other species occurred nearly year‐round, with distinct peaks of abundance in the dry season (April to October), supporting the hypothesis that species of Agrotina are well adapted to dry environments. The association of cutworms with dry environments was recovered for multivoltine, abundant species, such as A. ipsilon and F. subterranea, as for univoltine species, such as F. submontana. Across eight crop seasons, the abundance of all species decreased, coinciding with a high intensity El Niño effect. However, the effect itself was not found to be significant to predict the temporal distribution and abundances of cutworms and the causes of population decrease from 2014 to 2015 crop season remain to be explained. After the temporal autocorrelation effects were removed, it was revealed that the abundance of cutworms tends to be larger in crop seasons with less precipitation. Thus, this variable can be used to predict outbreaks of cutworms in the Cerrado. Some species of cutworms deserve special concern due to their frequency, seasonality and higher abundances in the Cerrado during the dry season. Their adaptability to adverse conditions may increase their spatio‐temporal distribution in Brazil and the frequency of outbreaks in a scenario of climate change, with the continuing reduction of rainfall in central and southeastern Brazil.
Physical Activity, Exercise, and Sports in Individuals with Skeletal Dysplasia: What Is Known about Their Benefits?

There is a lack of knowledge about the practice of physical activity, exercise, and sports in people with skeletal dysplasia (SD). This study aimed to characterize the physical fitness of people with SD; investigate the benefits of physical activity, exercise, or sports programs for people with SD; identify the adapted physical activities that can be prescribed to individuals with SD; and identify the most common and effective structural characteristics and guidelines for the evaluation of individuals with SD and corresponding activity prescriptions. Electronic searches were carried out in the PubMed, Scopus, SPORTDiscus, Psycinfo, and Web of Science databases in October 2021 and March 2022 and included papers published until 3 March 2022. The search strategy terms used were “dwarfism”, “dwarf”, “skeletal dysplasia”, “achondroplasia”, “pseudoachondroplasia”, “hypochondroplasia”, “campomelic dysplasia”, “hair cartilage hypoplasia”, “x-linked hypophosphatemia”, “metaphyseal chondrodysplasia schmid type”, “multiple epiphyseal dysplasia”, “three M syndrome”, “3-M syndrome”, “hypophosphatasia”, “fibrodysplasia ossificans progressive”, “type II collagen disorders”, “type II collagenopathies”, “type II collagenopathy”, “physical activity”, “exercise”, “sport”, “training”, and “physical fitness”, with the Boolean operators “AND” or “OR”. After reading the full texts of the studies, and according to previously defined eligibility criteria, fifteen studies met the inclusion criteria; however, there was not a single intervention study with physical exercise. Several cross-sectional, review, or qualitative studies presented a set of essential aspects that future intervention studies can consider when evaluating, prescribing, and implementing physical exercise programs, as they allowed the physical characterization of the SD population. This study demonstrated an apparent scarcity in the literature of experimental studies with physical exercise implementation in the SD population.
Promoting college students’ mindfulness, mental health, and self-compassion in the time of COVID-19: feasibility and efficacy of an online, interactive mindfulness-based stress reduction randomized trial

ABSTRACT College students are experiencing heightened mental health difficulties, with problems intensifying during the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) is a group intervention focused on cultivating mindfulness skills, with demonstrated efficacy in reducing psychopathology and bolstering mental health. This pilot randomized trial assessed the feasibility, engagement, and efficacy of an online adaptation of MBSR among healthy college students during the COVID-19 pandemic. Participants were randomly allocated to either an adapted MBSR group (n = 17) or a control group (n = 10). Participants completed mental health questionnaires prior to, and following the intervention. The intervention was demonstrated to be feasible and participants were engaged. Mindfulness-Based Stress Reduction participants reported greater increases over time in mindful self-compassion and observing mindfulness compared to control participants. Mindfulness-Based Stress Reduction participants demonstrated marginally greater overall mindfulness and well-being over time. This study identified small, clinically meaningful mental health effects of an online adaptation of MBSR among college students.
Improved Molecular Docking of MAO-B Inhibitors with Glide

Molecular docking is an essential structure-based technique that is frequently used for virtual screenings. In most cases, the precision of search algorithms of the modern docking programs is satisfactory. However, the scoring algorithms' accuracy is not sufficient to completely distinguish true positives from inactive solutions. Therefore, initial validation processes could elevate the docking enrichments. This paper proposes a validated molecular docking approach applying Glide’s HTVS mode to discover novel Monoamine Oxidase B (MAO-B) ligands. In addition, more precise docking modes (SP and XP) and the influence of free binding energy calculations (MM/GBSA) over the enrichment values were observed. The developed Glide’s docking protocol demonstrated good enrichment values, outperforming GOLD 5.3. Moreover, the XP docking mode displayed the most reliable results, while the utilization of SP and MM/GBSA simulations led to poor performances. Overall, we demonstrated that virtual screenings of large databases in 2V5Z utilizing HTVS mode followed by XP rescoring are suitable molecular docking protocols for acquiring novel MAO-B inhibitors.
In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions

Inhibition of human DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) by different chiral lipophilic nucleoside derivatives was studied. New Tdp1 inhibitors were found in the series of the studied compounds with IC50 = 2.7–6.7 μM. It was shown that D-lipophilic nucleoside derivatives manifested higher inhibition activity than their L-analogs, and configuration of the carbohydrate moiety can influence the mechanism of Tdp1 inhibition.
Wafer‐Scale 2H‐MoS2 Monolayer for High Surface‐enhanced Raman Scattering Performance: Charge‐Transfer Coupled with Molecule Resonance

The surface‐enhanced Raman scattering (SERS) as a novel and efficient analytic technique to probe molecules has attracted tremendous attention. Semiconducting substrates have been widely investigated for their applications into SERS because of their easy integration with electronic devices. In this work, a wafer‐scale semiconducting MoS2 monolayer (2H‐MoS2‐ML) without additional treatment is used as the SERS substrate, which shows the naturally formed MoS2 ML has excellent chemical stability, high uniformity, and high sensitivity. It is found that the detection concentration limit can reach 1 × 10−8 m and the enhancement factor is about 4.5 × 106 for the rhodamine 6G (R6G) under a 532 nm excitation laser, which is the highest SERS performance observed on 2H‐MoS2‐ML up to now. The experimental and computational studies reveal that the photo‐enhanced charge transfer coupled with molecule resonance contribute to remarkable SERS. In addition to R6G, 2H‐MoS2‐ML shows good SERS signals on the detection of amaranth and crystal violet too. The findings not only provide an insightful understanding of the mechanism for the improved SERS performance of semiconducting transition‐metal dichalcogenides (TMDs) MLs, but are helpful for the design of novel SERS substrates. It is expected that the wafer‐scale TMDs may find practical applications in SERS.
Students ‘Attitude Towards the Utilization of Google Classroom for Learning

This study investigates students' attitudes towards the use of Google Classroom for learning at the University of Ilorin, Nigeria. Descriptive survey research is used in this study. The population for this study consisted of all students at the University of Ilorin, Nigeria. The population of this study consisted of undergraduates in ten selected faculties at the University of Ilorin. Samples were taken using a multi-stage sampling technique. Use of stratified sampling technique to divide the population into strata based on faculty. Then, random sampling technique was used to select 30 respondents from each stratum. Specifically, 30 undergraduate students were selected from ten faculties, bringing the total number of respondents to 300 people. The research finding is that students have a positive attitude towards the use of Google Classroom at the University of Ilorin. Gender has no significant effect on student attitudes towards the use of Google Classroom at Ilorin University. The research course did not have a significant effect on respondents' attitudes towards the use of Google Classroom at the University of Ilorin. The study concludes that Google Classroom's diverse potential can be harnessed and harnessed to transform teaching and learning processes from traditional chalk-talk methods to virtual or blended learning, which is increasingly recognized as a global best practice in the university field. It is recommended that University lecturers be encouraged to use Google Classroom because of the many benefits it has for teaching and learning.
How to Measure Organic Fruit Consumer Behavior: A Systematic Review

This review article seeks to systematically identify appropriate ways to measure the consumption behavior of organic fruits. The systematic review of the literature was performed according to the criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the eligibility criteria were declared through the PICOS (population, interventions, comparators, outcomes, and study) tool based on 277 article records scientiometrically identified in both the Journal Citation Report databases from Web of Science. The literature review stages determined a reduced set of articles that presented valid and reliable measurement scales that covered determinant constructs in organic fruit consumer behavior (OFCB). The measurement scale with the best results reported within the screened articles covered the constructs related to health, fear, environment, effort, and economy, allowing it to serve as a reference instrument in further studies on food consumer behavior.
Influence of Project and Affected Local Community Interests Level on Social Conflicts in Indonesian Infrastructure Projects

Poor economic growth due to Covid-19 pandemic in the last two years has resulted in a decline in indicators of public welfare. The construction industry sector also experienced a severe decline in productivity;thus, adjustments had to be made to survive the crisis situation. In addition, environmental problems due to development activities also threaten the lives and incomes of people who depend on natural products. These conditions encourage the escalation of interests that affect infrastructure projects in Indonesia. This study aimed to predict the influence of project and affected local community's interests on infrastructure projects social conflicts. Data were obtained by questionnaire from 68 project managers as respondents and analyzed using PLS-SEM. The findings of this study are that the influence of affected community is more dominant than that of project interests on project social conflicts. This shows the important role of communities in the concept of sustainable development with environmental and social perspectives. The results of this study will be useful in drafting the concept of an integrated and standardized environmental and social safeguard framework. To achieve an appropriate framework, further research is needed to examine the framework concept as a moderation of the relationship between interests and project social conflicts. © 2022 Materials and Energy Research Center. All rights reserved.
Synergistic Effect of Cetuximab in Combination with Bee Venom: A Novel Approach for the Treatment of Colon Cancer

Anti-EGFR monoclonal antibody (cetuximab) is a promising new targeted therapy for cancer treatment currently approved to treat colon cancer. The synergistic effect of (Ce/BV) on two colon cancer cell lines (HCT116 and Caco-2) was investigated in this work to get the lowest lethal dosages of cetuximab. MTT assay was used to evaluate the cytotoxic effect of cetuximab, bee venom, and their combination. Flow cytometry analysis was used to look at cell cycle distribution and apoptosis induction. RT-PCR can identify changes in apoptotic genes expression. The results show that cetuximab and BV have IC50 against Caco-2 (686 and 10.5 g/ml, respectively) and HCT-116 (740 and 13 g/ml, respectively). According to the results, the combination treatment had a synergistic inhibitory impact on two cell lines (CI< 1). Both cell lines were arrested in the G2/M phase of the cell cycle. In addition, when combination therapy was used instead of cetuximab alone, apoptosis was dramatically increased in both cell lines. In addition, after treatment with (Ce/BV), Bcl2 and p53 were shown to be down-regulated and up-regulated, respectively, in two cell lines. As a result, the combination of cetuximab and BV showed preclinical efficacy in the treatment of colon cancer
Effects of non-adjacent letter repetition in the same-different matching task

ABSTRACT Effects of non-adjacent character repetition were investigated using the same-different matching task. We compared matching of strings of 5 consonants with matching of 5 symbols in order to distinguish letter-specific mechanisms from generic order encoding mechanisms. Character repetition was found to facilitate “same” responses to both types of stimuli, but crucially the interfering effect of repetition on “different” responses was only significant with letter strings. However, the latter effect only emerged in response times (as well as error rates) when the repetition occurred in the target string as opposed to the reference string. We conclude that inhibitory effects of letter repetition reflect the operation of a letter-specific order encoding mechanism, and that letter repetition in the target string has a greater influence than letter repetition in the reference string when making “different” responses in the same-different matching task.