Miracle-dz/UniFAR-FTUs huggingface dataset:
A Helping Hand Goes a Long Way: Long-Term Effects of Counselling and Support to Workfare Program Participants

: There is a growing realization that in order to help low-income households achieve self-sufficiency it is necessary to address both economic disincentives to work as well as behavioral barriers that prevent the poor from finding and retaining employment. To explore this empirically, we study the long-run impacts of the Self-Sufficiency Project (SSP) Plus experiment, which randomly assigned chronic welfare recipients to receive temporary work subsidies and intensive employment support services. We examine whether this intervention lead to permanent changes in individuals’ socioeconomic trajectories. We link study participants to their federal tax records to follow them up to 20 years after random assignment. Compared to those receiving only the temporary work subsidies or no intervention, we find that the added support services of the SSP Plus program led to a large increase in full-time employment and an analogous decrease in the receipt of Social Assistance throughout the first decade post-intervention. We also find a permanent 20- 27 percent increase in participants’ annual earnings over the 20-year period. We show evidence consistent with the retention of jobs that are of higher quality as an important pathway of these long-term effects. Taken together, the results indicate that the intensive support services offered through the program significantly transformed the lives of these individuals. Estimates of the average annual incremental effects of SSP Plus employment services on welfare receipt in years 9-12, 13-16, and 17-20, respectively, are all negative in sign but are smaller in magnitude and not statistically significant.
Securing Age-of-Information (AoI)-Enabled 5G Smart Warehouse Using Access Control Scheme

Low-power wireless sensor networks (WSNs) and Internet of Things (IoT) have great impact for the real-time applications in future 5th generation (5G) mobile networks due to the wireless-powered communication technologies. The Age of Information (AoI) plays a crucial performance metric in an IoT-enabled real-time smart warehouse application, where the freshness of the aggregated data is very important. However, wireless medium communication among the beacon nodes and the user equipments (tracking nodes) gives an opportunity to an adversary not only to eavesdrop the data but also to corrupt the data by means of deleting, modifying or inserting malicious information during communication among the entities involved in the smart warehouse environment. To mitigate these issues, we design a security scheme for AoI-enabled 5G smart warehouse through an access control mechanism, where the secure communication among the beacon nodes and the tracking nodes will take place by mutual device authentication and key agreement process. The fresh data collected at the enterprise cloud is then used for big data analytics for better predictions and analysis, such as optimal device scheduling so that the data becomes very fresh. The rigorous security analysis and comparative study show that the proposed mechanism has significantly better security and comparable communication and computational costs as compared to the relevant schemes. In addition, through the real-time testbed experiments, we show that the proposed scheme is practical in 5G smart warehouse context.
Information behaviour in high risk decision making: Study of international postgraduates

This article explores the role of information in high risk consumer decision making. Forty-two qualitative interviews were undertaken with international non-EU postgraduates when making the high risk decision to study in a UK Business School. Prospective international postgraduates moved iteratively through the stages in Kuhlthau’s Information Search Process model and learnt from the search process they had undertaken in a continuous cyclical manner. Word-of-mouth recommendations were the most influential sources of information gathered, and online sources were perceived to be credible regardless of their origins. The perception of risk impacted the rigour of the information search process. An iterative decision making cycle model is proposed with Kuhlthau’s model and word of mouth information at its core, which reflects the connectedness of individuals in this digital era. This study provides new insights by combining both marketing and LIS models and extends Kuhlthau’s research into a new context.
Vertical and uniform growth of MoS2 nanosheets on GO nanosheets for efficient mechanical reinforcement in polymer scaffold

ABSTRACT Graphene oxide (GO) and molybdenum disulphide (MoS2), have drawn more and more attention as reinforcement in polymer. However, their large specific surface area and strong van der Waals forces result in serious aggregations in polymer matrix, which restrains the reinforcement effect. In this study, MoS2 nanosheets were in situ synthesised vertically and uniformly on the surface of GO nanosheets with the help of a hexadecyl trimethyl ammonium bromide (CTAB) assisted hydrothermal process to facilitate their dispersion in polylactic acid (PLLA) scaffold manufactured via selective laser sintering (SLS). The experimental results revealed that the 1.5 wt% GO/MoS2 nanocomposite exhibited better dispersion state compared with the 1.5 wt% GO and 1.5 wt% MoS2 in PLLA matrix. Therefore, the PLLA scaffold loading 1.5 wt% GO/MoS2 presented 10.2 and 1461 MPa of tensile strength and modulus with enhancement of 61% and 58%, respectively, compared with the pure PLLA scaffold. The reinforcement mechanisms mainly included crack deflection, crack bridging, crack pinning and pulling out of GO/MoS2. What’s more, the GO/MoS2-PLLA scaffold possessed benign cytocompatibility for cell behaviour, suggesting hopeful applications in bone defect repair.
A Geometric Morphometric Study on Sexual Dimorphism in Viscerocranium

Simple Summary Sex estimation is a crucial step in the identification of unknown bone remains. The accuracy of sex estimation methods depends on the level of sexual dimorphism manifested by the human bones. Therefore, the evaluation of sex differences of particular bones of the skeleton is an important preceding stage. We have used geometric morphometric techniques to investigate the sexual dimorphism in the size and shape of the facial part of the skull and its subregions. Our results show that the facial skeleton in males and females differs more in size than in shape, so its overall size is a more useful sex indicator than its shape. The same result is observed for all facial subregions studied here. However, the best discrimination between the male and female skulls is achieved when both size and shape are considered together. Abstract The level of sexual dimorphism manifested by human bones is an important factor for development of effective sex estimation methods. The aim of the study was to investigate the sexual dimorphism in the size and shape of the viscerocranium using geometric morphometric techniques. It also aimed to explore the sex differences in distinct viscerocranial regions and to establish the most dimorphic region with regard to size and shape. Computed tomography images of 156 males and 184 females were used in the study. Three-dimensional coordinates of 31 landmarks were acquired. Five landmark configurations were constructed from the viscerocranium and its orbital, nasal, maxillary, and zygomatic region. Generalized Procrustes superimposition, principal component analysis, and discriminant analysis were applied to each configuration. The significance of the sex differences in size and shape was assessed and significant differences were found in all configurations. The highest accuracy was obtained from both shape and size of the whole viscerocranium. Based on size only, the highest accuracy was achieved by the nasal region. The accuracy based on shape was generally low for all configurations, but the highest result was attained by the orbital region. Hence, size is a better sex discriminator than shape.
Prevalence and characteristics of referred pain in patients diagnosed with temporomandibular disorders according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) in Sharjah, United Arab Emirates

Background: Referred pain often complicates and delays the diagnosis of temporomandibular disorders (TMD). Elaborating the prevalence and characteristics of TMD-associated referred pain as well as the distribution of referred pain in different TMD classes will significantly improve the diagnostic process. The objectives of the present study were to assess the prevalence and to evaluate the characteristics of referred pain associated with TMD diagnosed according to the DC/TMD. Methods: A total of 252 patients were evaluated using the DC/TMD Axes-I and –II assessment tools. Different modalities were used to treat the diagnosed TMD. Referred pain was diagnosed when the location of the perceived pain in response to palpation extended beyond the boundary of the structure that was examined. For pain locations that were perceived as deep, patients were asked to locate the surface of the area of pain. The result of the assessment was identified as positive if the patient described his perceived pain during the clinical examination as being familiar pain that was experienced in the same location in the last 30 days. Results: TMD-associated referred pain was recorded in 153 patients (60.7%). The most common referred pain location was the temporal area (45.2%), followed by the ear (42.1%). The referred pain was recorded in disc displacement with reduction with intermittent locking and myofascial pain with referral in all patients (100%). The proportion of patients with referred pain was significantly different between the different TMD diagnostic subgroups (P < 0.001). The recorded percentage of improvement in the referred pain following the treatment was 50.41% after 3 months and 56.65% after 6 months. Conclusions: Referred pain is a prominent feature of TMD. The prevalence of referred pain associated with TMD was 60.7%. A strong strength association between the different diagnostic subgroups and the presence of referred pain existed.
Active Compounds Screening and Hepatoprotective Mechanism of Shuganning Injection Based on Network Pharmacology and Experimental Validation

Objective: The study aimed to analyze the core active compounds and the potential mechanism of Shuganning injection (SGNI) through network pharmacology with biological experiments. Methods: Active compounds and targets of SGNI were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and Targetnet database, whereas the liver disease-related targets were identified through the Genecards and Online Mendelian Inheritance in Man databases. The “compound-target” and “protein-protein interaction” networks construction, core target identification, and pathway enrichment were then performed. Finally, the exploration of the mechanism of action for SGNI against acetaminophen (APAP)-induced liver injury in the HepaRG cells and validation of three identified protein targets was also carried out through western blot assay, including tumor protein p53 (p53, TP53), transcription factor Jun (Jun), and Caspase 3 (CASP3). Results: The result showed that a total of 312 active compounds of SGNI and 408 liver disease-related targets, as well as 131 core targets were revealed through databases, such as prostaglandin G/H synthase 1, prostaglandin G/H synthase 2, and nuclear factor NF-kappa B (NF-kB) p65 subunit (RELA). The core targets of SGNI were involved in regulating hepatitis B signaling pathway, NF-kB signaling pathway, Toll-like receptor signaling pathway, and tumor necrosis factor (TNF) signaling pathway. Moreover, results of molecular docking in this study indicated that chlorogenic acid, geniposide, baicalin, indirubin, and ganoderic acid A could act on RELA, JUN, TP53, TNF, CASP3, Caspase 8 (CASP8) and nuclear factor NF-kB p105 subunit (NFKB1). Similarly, results of western blot revealed that SGNI reduced the expression of p53, Jun, and Caspase 3 proteins in HepaRG cells as compared with the APAP group (P < 0.01 or P < 0.05). Conclusion: The present study verified the therapeutic effects and mechanism of SGNI on liver diseases and pointed out new directions for further research.
Normal modes of a compound drop

The modes are characterized by their frequency, the attendant displacement of fluid boundaries, and the flow pressure fields within the fluids. The drops consist of three fluids; a core fluid, a fluid shell surrounding the core, and a host fluid surrounding the shell. These fluids are assumed to be inviscid and incompressible, and the core and the shell to be concentric. The theory is obtained by linearization of the equations of fluid motion to the lowest order of nonlinearity that yields the normal modes. Numerical values of mode frequencies and the associated relative displacements of the fluid boundaries are presented for several specific systems, and the results compared with observations.
Counting Calories : Studies of Energy Loss in a Segmented Calorimeter

The Gamma-ray Large Area Space Telescope (GLAST) is a space mission with anticipated launch in 2007. The aim is to study the gamma-ray sky in the energy range 10 keV – 300 GeV. The GLAST electromagnetic calorimeter is 8.6X0 deep and has a total of 1536 CsI(Tl) crystals each measuring 32.62. x2.67x1.99 cm3. The crystals are read out at both ends with PIN photodiodes.As a part of the quality control procedure during crystal production, samples from all CsI(Tl) boules were irradiated with gamma-rays from a 60Co source. The average decrease in light yield was found to be (13.4±0.7)% after 100 Gy, 5 times the expected dose during a 5 year mission. The correspondence between the radiation damage of boule samples and the full-sized crystals were examined. A full-size crystal was also irradiated with a 180 MeV proton beam, with a decrease in light yield of (22±5)% after a dose of 175 Gy. The induced radioactivity of the crystal was also studied and a number of radioactive nuclei could be identified.Detailed simulations of electron- and photon-induced showers in a segmented CsI calorimeter have been performed in the energy range 1 – 100 GeV, and for incident angles 0°, 30° and 60°. The energy distributions in the 1.99 cm (1.08X0) thick layers were found to change systematically along the shower, varying little with initial energy. Three probability distributions have been fitted to the data: negative binomial, log-normal and Gaussian distributions. The energy fluctuations generated from non-perpendicular incident were similar to those for perpendicular incidence.Two energy reconstruction methods were also studied, shower profile fitting and leakage correction. The latter gave better energy resolution, 5.1% and 7.6% (6.6% and 9.1%) for 1 GeV and 10 GeV electrons (photons) in the segmented 8.6X0 calorimeter. A third method, using a maximum likelihood method is also discussed.
Psychophysiological Effects of a Natural Forest Environment on Chinese University Students Aged 19-25 Years

ABSTRACT Recall of natural environments evokes human psychophysiological response, there is a lack of systematic, comprehensive analysis in existing research. Moreover, the limited experimental conditions lead to various laboratory research, and more field studies are needed. Employing the field research design and relative environmental psychology methods, this research investigates physical and psychological indexes changes of 60 Chinese university students aged 19–25, which include positive affect (PA), negative affect (NA), heart rate (HR), heart-rate variability (HRV), concentration (Pa), and relaxation (Pm), and regards the Zhangjiajie National Forest Park in China as the experimental site. This study evaluates the psychophysiological effects of the natural forest environment on participates and explores the overall psychophysiological changes, and verifies the positive effect of the natural forest environment on university students. The main findings indicated that the natural forest environment was beneficial for increasing positive affect, decreasing negative affect, affecting HR, and increasing HRV, Pa and Pm. This study adds some basic evidence to a growing theoretical literature emphasizing the role of natural forest environment in psychophysiological restoration.
Clinical characterization of anophthalmic and microphthalmic cavities in individuals with craniofacial anomalies

Objective Measure the frequency of anophthalmic and microphthalmic patients with craniofacial anomalies (FCAs). Design Descriptive, cross-sectional, retrospective study. Setting Hospital for Rehabilitation in Craniofacial Anomalies of the University of São Paulo (HRAC-USP, Paulo, Brazil). Patients The medical records of patients treated at HRAC from 2000 to 2012 with a diagnosis of anophthalmia or congenital microphthalmia were examined. Patients were excluded for secondary anophthalmia, incomplete medical records, or information that could not be accessed. Outcome Measures Frequency of anophthalmia and microphthalmia; the proportions and diagnoses of associated FCAs; impairment of ocular appendages; extracranial or facial anomalies; genetic alterations; and surgical approach. Results A total of 56 patients had anophthalmia (52.3%), 35 had microphthalmia (32.7%), and 16 patients had both (15%). Individuals with FCAs associated with microphthalmia, anophthalmia, or both totaled 74, corresponding to 69.2%. Anophthalmia was more likely than microphthalmia to be accompanied by FCAs, at 76.4% of patients (p < 0.05). Cleft lip and palate were the main malformations associated with anophthalmia (23.64%), with microphthalmia (45%), and with both (44.44%). Reconstructive surgery was done in 63.6% of cases. The ocular attachments were compromised in 71% of cases. Extracraniofacial malformations were found in 9.3% of patients. Only seven records contained karyotypes, and no changes directly related to anophthalmia or microphthalmia were found. Conclusion Anophthalmia is more frequent than microphthalmia and is more often accompanied by FCA. Cleft lip and cleft palate are the most frequent concomitant malformations. ABSTRACT Objective Measure the frequency of anophthalmic and microphthalmic patients with craniofacial anomalies (FCAs). Design Descriptive, cross-sectional, retrospective study. Setting Hospital for Rehabilitation of Craniofacial Anomalies of the University of São Paulo (HRAC-USP, Bauru, São Paulo, Brazil).
New Drug Design Avenues Targeting Alzheimer’s Disease by Pharmacoinformatics-Aided Tools

Neurodegenerative diseases (NDD) have been of great interest to scientists for a long time due to their multifactorial character. Among these pathologies, Alzheimer’s disease (AD) is of special relevance, and despite the existence of approved drugs for its treatment, there is still no efficient pharmacological therapy to stop, slow, or repair neurodegeneration. Existing drugs have certain disadvantages, such as lack of efficacy and side effects. Therefore, there is a real need to discover new drugs that can deal with this problem. However, as AD is multifactorial in nature with so many physiological pathways involved, the most effective approach to modulate more than one of them in a relevant manner and without undesirable consequences is through polypharmacology. In this field, there has been significant progress in recent years in terms of pharmacoinformatics tools that allow the discovery of bioactive molecules with polypharmacological profiles without the need to spend a long time and excessive resources on complex experimental designs, making the drug design and development pipeline more efficient. In this review, we present from different perspectives how pharmacoinformatics tools can be useful when drug design programs are designed to tackle complex diseases such as AD, highlighting essential concepts, showing the relevance of artificial intelligence and new trends, as well as different databases and software with their main results, emphasizing the importance of coupling wet and dry approaches in drug design and development processes.
A topological invariant arising in the stability analysis of travelling waves.

Travelling waves are special Solutions of partial differential equations in one space variable. They are characterized by their time invariant profile; indeed, s Solutions they evolve by translating at constant speed in the one spatial dimension. These Solutions are often the centerpiece of a physical System s they represent the transport of Information in a single direction. It is of fundamental importance for a given travelling wave to determine its stability relative to perturbations in the initial conditions for Solutions of the f ll partial differential equations. Stable Solutions are the most physically realistic since the external world provides enough perturbations that we can only expect to see waves which will dampen out these perturbations.
The Relative Abundances of Human Leukocyte Antigen-E, α-Galactosidase A and α-Gal Antigenic Determinants Are Biased by Trichostatin A-Dependent Epigenetic Transformation of Triple-Transgenic Pig-Derived Dermal Fibroblast Cells

The present study sought to establish the mitotically stable adult cutaneous fibroblast cell (ACFC) lines stemming from hFUT2×hGLA×HLA-E triple-transgenic pigs followed by trichostatin A (TSA)-assisted epigenetically modulating the reprogrammability of the transgenes permanently incorporated into the host genome and subsequent comprehensive analysis of molecular signatures related to proteomically profiling the generated ACFC lines. The results of Western blot and immunofluorescence analyses have proved that the profiles of relative abundance (RA) noticed for both recombinant human α-galactosidase A (rhα-Gal A) and human leukocyte antigen-E (HLA-E) underwent significant upregulations in tri-transgenic (3×TG) ACFCs subjected to TSA-mediated epigenetic transformation as compared to not only their TSA-unexposed counterparts but also TSA-treated and untreated non-transgenic (nTG) cells. The RT-qPCR-based analysis of porcine tri-genetically engineered ACFCs revealed stable expression of mRNA fractions transcribed from hFUT2, hGLA and HLA-E transgenes as compared to a lack of such transcriptional activities in non-transgenic ACFC variants. Furthermore, although TSA-based epigenomic modulation has given rise to a remarkable increase in the expression levels of Galα1→3Gal (α-Gal) epitopes that have been determined by lectin blotting analysis, their semi-quantitative profiles have dwindled profoundly in both TSA-exposed and unexposed 3×TG ACFCs as compared to their nTG counterparts. In conclusion, thoroughly exploring proteomic signatures in such epigenetically modulated ex vivo models devised on hFUT2×hGLA×HLA-E triple-transgenic ACFCs that display augmented reprogrammability of translational activities of two mRNA transcripts coding for rhα-Gal A and HLA-E proteins might provide a completely novel and powerful research tool for the panel of further studies. The objective of these future studies should be to multiply the tri-transgenic pigs with the aid of somatic cell nuclear transfer (SCNT)-based cloning for the purposes of both xenografting the porcine cutaneous bioprostheses and dermoplasty-mediated surgical treatments in human patients.