Miracle-dz/UniFAR-FTUs huggingface dataset:
Cost-Effectiveness Analysis of Local Ablation and Surgery for Liver Metastases of Oligometastatic Colorectal Cancer

Simple Summary Colorectal cancer is among the most prevalent cancers worldwide, with every second patient developing liver metastasis during their illness. For treatment of oligometastatic patients, there are several alternatives such as surgery, microwave ablation (MWA) and radiofrequency ablation (RFA). Our aim was to evaluate the cost-effectiveness for each strategy, accounting for short- and long-term costs and efficacy. The analysis demonstrated that MWA and surgery offer a comparable efficacy. MWA was the most cost-effective strategy in intermediate resource settings, and can be considered a cost-effective alternative to surgery in high resource settings. Abstract Background: Colorectal cancer is among the most prevalent cancer entities worldwide, with every second patient developing liver metastases during their illness. For local treatment of liver metastases, a surgical approach as well as ablative treatment options, such as microwave ablation (MWA) and radiofrequency ablation (RFA), are available. The aim of this study is to evaluate the cost-effectiveness of RFA, MWA and surgery in the treatment of liver metastases of oligometastatic colorectal cancer (omCRC) that are amenable for all investigated treatment modalities. Methods: A decision analysis based on a Markov model assessed lifetime costs and quality-adjusted life years (QALY) related to the treatment strategies RFA, MWA and surgical resection. Input parameters were based on the best available and most recent evidence. Probabilistic sensitivity analyses (PSA) were performed with Monte Carlo simulations to evaluate model robustness. The percentage of cost-effective iterations was determined for different willingness-to-pay (WTP) thresholds. Results: The base-case analysis showed that surgery led to higher long-term costs compared to RFA and MWA (USD 41,848 vs. USD 36,937 vs. USD 35,234), while providing better long-term outcomes than RFA, yet slightly lower than MWA (6.80 vs. 6.30 vs. 6.95 QALYs for surgery, RFA and MWA, respectively). In PSA, MWA was the most cost-effective strategy for all WTP thresholds below USD 80,000 per QALY. Conclusions: In omCRC patients with liver metastases, MWA and surgery are estimated to provide comparable efficacy. MWA was identified as the most cost-effective strategy in intermediate resource settings and should be considered as an alternative to surgery in high resource settings.
Association of Dietary Total Antioxidant Capacity with Bone Mass and Osteoporosis Risk in Korean Women: Analysis of the Korea National Health and Nutrition Examination Survey 2008–2011

Antioxidant intake has been suggested to be associated with a reduced osteoporosis risk, but the effect of dietary total antioxidant capacity (TAC) on bone health and the risk of osteoporosis remains unclear. We aimed to assess the hypothesis that dietary TAC is positively associated with bone mass and negatively related to the risk of osteoporosis in Korean women. This cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey. Dietary TAC was estimated using task automation and an algorithm with 24-h recall data. In total, 8230 pre- and postmenopausal women were divided into four groups according to quartiles of dietary TAC. Dietary TAC was negatively associated with the risk of osteoporosis (odds ratio, 0.73; 95% confidence interval, 0.54–0.99; p-value = 0.045) in postmenopausal women, but not in premenopausal women. Dietary TAC was positively associated with bone mineral content (BMC) and bone mineral density of the femoral neck and lumbar spine in postmenopausal women and BMC of the total femur and lumbar spine in premenopausal women. Our study suggests that dietary TAC is inversely associated with the risk of osteoporosis in postmenopausal women and positively associated with bone mass in both pre- and postmenopausal women.
Analysis of Fibre Cross-Coupling Mechanisms in Fibre-Optical Force Sensors †

The force-enhanced light coupling between two optical fibres is investigated for the application in a pressure or force sensor, which can be arranged into arrays and integrated into textile surfaces. The optical coupling mechanisms such as the influence of the applied force, the losses at the coupling point and the angular alignment of the two fibres are studied experimentally and numerically. The results reveal that most of the losses occur at the deformation of the pump fibre. Only a small percentage of the cross-coupled light from the pump fibre is actually captured by the probe fibre. Thus, the coupling and therefore the sensor signal can be strongly increased by a proper crossing angle between the fibres, which lead to a coupling efficiency of 3%, a sensitivity improvement of more than 20 dB compared to the orthogonal alignment of the two fibres.
Stem Cell Therapy for Microvascular Injury Associated with Ischemic Nephropathy

Ischemic nephropathy reflects progressive loss of kidney function due to large vessel atherosclerotic occlusive disease. Recent studies indicate that this process is characterized by microvascular rarefaction, increased tissue hypoxia and activation of inflammatory processes of tissue injury. This review summarizes the rationale and application of functional MR imaging to evaluate tissue oxygenation in human subjects that defines the limits of renal adaptation to reduction in blood flow, development of increasingly severe tissue hypoxia and recruitment of inflammatory injury pathways in ischemic nephropathy. Human mesenchymal stromal/stem cells (MSC) are capable of modifying angiogenic pathways and immune responses, but the potency of these effects vary between individuals and various clinical characteristics including age and chronic kidney disease and levels of hypoxia. We summarize recently completed first-in-human studies applying intrarenal infusion of autologous adipose-derived MSC in human subjects with ischemic nephropathy that demonstrate a rise in blood flow and reduction in tissue hypoxia consistent with partial repair of microvascular injury, even without restoring main renal arterial blood flow. Inflammatory biomarkers in the renal vein of post-stenotic kidneys fell after MSC infusion. These changes were associated with modest but significant dose-related increments in kidney function. These data provide support a role for autologous MSC in repair of microvascular injury associated with tissue hypoxia.
Diet-Related Mobile Apps to Promote Healthy Eating and Proper Nutrition: A Content Analysis and Quality Assessment

Dietary mobile applications (apps) continue to hold promise for facilitating a healthy diet and managing nutrition. However, few studies have objectively evaluated the content and quality of such apps in Korea. The present study assessed the content and quality of dietary mobile apps using the Mobile App Rating Scale (MARS). We selected 29 dietary apps based on keywords and eligibility criteria for inclusion in the analyses. We conducted regression analyses to examine the association between app content and MARS scores. Most of the apps featured a tracking tool, while few featured rewards or follow-up management. Our quality assessment revealed that the top-rated apps have distinct levels of quality in terms of MARS scores. The regression analyses showed that the ways in which the apps provide information and motivate the users are statistically significant predictors of app quality. Our findings may facilitate the selection of dietary apps in Korea and provide guidelines for app developers regarding potential improvements in terms of content and quality.
Complexity-guided Fourier phase retrieval from noisy data.

Reconstruction of a stable and good quality solution from noisy single-shot Fourier intensity data is a challenging problem for phase retrieval algorithms. We examine behavior of the solution provided by the hybrid input-output (HIO) algorithm for noisy data, from the perspective of the complexity guidance methodology that was introduced by us in an earlier paper [J. Opt. Soc. Am. A36, 202 (2019)JOAOD60740-323210.1364/JOSAA.36. 000202]. We find that for noisy data, the complexity of the solution outside the support keeps increasing as the HIO iterations progress. Based on this observation, a strategy for controlling the solution complexity within and outside the support during the HIO iterations is proposed and tested. In particular, we actively track and control the growth of complexity of the solution outside the support region with iterations. This in turn provides us with guidance regarding the level to which the complexity of the solution within the support region needs to be adjusted, such that the total solution complexity is equal to that estimated from raw Fourier intensity data. In our studies, Poisson noise with mean photon counts per pixel in the Fourier intensity data ranges over four orders of magnitude. We observe that the performance of the proposed strategy is noise robust in the sense that with increasing noise, the quality of the phase solution degrades gradually. For higher noise levels, the solution loses textural details while retaining the main object features. Our numerical experiments show that the proposed strategy can uniformly handle pure phase objects, mixed amplitude-phase objects, and the case of dc blocked Fourier intensity data. The results may find a number of applications where single-shot Fourier phase retrieval is critical to the success of corresponding applications.
Biodegradation of Emerging Pharmaceuticals from Domestic Wastewater by Membrane Bioreactor: The Effect of Solid Retention Time

Although conventional biological treatment plants can remove basic pollutants, they are ineffective at removing recalcitrant pollutants. Membrane bioreactors contain promising technology and have the advantages of better effluent quality and lower sludge production compared to those of conventional biological treatment processes. In this study, the removal of pharmaceutical compounds by membrane bioreactors under different solid retention times (SRTs) was investigated. To study the effect of SRT on the removal of emerging pharmaceuticals, the levels of pharmaceuticals were measured over 96 days for the following retention times: 20, 30, and 40-day SRT. It was found that the 40-day SRT had the optimum performance in terms of the pharmaceuticals’ elimination. The removal efficiencies of the chemical oxygen demand (COD) for each selected SRT were higher than 96% at steady-state conditions. The highest degradation efficiency was observed for paracetamol. Paracetamol was the most removed compound followed by ranitidine, atenolol, bezafibrate, diclofenac, and carbamazepine. The microbial community at the phylum level was also analyzed to understand the biodegradability of pharmaceuticals. It was noticed that the Proteobacteria phylum increased from 46.8% to 60.0% after 96 days with the pharmaceuticals. The Actinobacteria class, which can metabolize paracetamol, carbamazepine, and atenolol, was also increased from 9.1% to 17.9% after adding pharmaceuticals. The by-products of diclofenac, bezafibrate, and carbamazepine were observed in the effluent samples.
Lifestyle Changes and Body Mass Index during COVID-19 Pandemic Lockdown: An Italian Online-Survey

Background. COVID-19 pandemic has imposed a period of contingency measures, including total or partial lockdowns all over the world leading to several changes in lifestyle/eating behaviours. This retrospective cohort study aimed at investigating Italian adult population lifestyle changes during COVID-19 pandemic “Phase 1” lockdown (8 March–4 May 2020) and discriminate between positive and negative changes and BMI (body mass index) variations (ΔBMI). Methods. A multiple-choice web-form survey was used to collect retrospective data regarding lifestyle/eating behaviours during “Phase 1” in the Italian adult population. According to changes in lifestyle/eating behaviours, the sample was divided into three classes of changes: “negative change”, “no change”, “positive change”. For each class, correlations with ΔBMI were investigated. Results. Data were collected from 1304 subjects (973F/331M). Mean ΔBMI differed significantly (p < 0.001) between classes, and was significantly related to water intake, alcohol consumption, physical activity, frequency of “craving or snacking between meals”, dessert/sweets consumption at lunch. Conclusions. During “Phase 1”, many people faced several negative changes in lifestyle/eating behaviours with potential negative impact on health. These findings highlight that pandemic exacerbates nutritional issues and most efforts need to be done to provide nutrition counselling and public health services to support general population needs.
Nurses’ Occupational Stress and Presenteeism: The Mediating Role of Public Service Motivation and the Moderating Role of Health

Presenteeism not only poses an economic cost to organizations but also generates reduced work efficiency and quality. The purpose of this study was to examine the connections between occupational stress, public service motivation (PSM), health, and presenteeism. A total of 981 nurses from 109 public hospitals in Jilin Province in China were enrolled in our study. Model 5 in the PROCESS micro was employed in order to verify the mediating effect of PSM and the moderating effect of nurses’ health on the relationship between occupational stress and presenteeism, and simple slope analysis was used to further determine the moderating effect. Both challenge stress and hindrance stress had a positive impact on presenteeism among nurses. PSM is a mediating variable between occupational stress and presenteeism. Health moderates the path between challenge stress and presenteeism, with the association being significant for nurses with low levels of health. Future policy making should focus on preventing presenteeism by reducing excessive stress, enhancing PSM, and improving nurse health and wellness.
Azo polymers for reversible optical storage. 2. Poly[4'-[[2-(acryloyloxy)ethyl]ethylamino]-2-chloro-4-nitroazobenzene]

Writing, reading, erasing and rewriting processes are performed using laser beams on a poly[4'-[[2-(acryloyloxy)ethyl]ethylamino]-4-nitroazobenzene] (pDRlA) film. The writing and erasing are statistical processes and the level of optical anisotropy induced depends on the photon flux directed at the sample. The time evolution of the writing process is investigated. A computer simulation of these processes is performed taking into account a relaxation process in which some of the reoriented trans molecules are randomized by thermal motion.
Blood Donations and Transfusions during the COVID-19 Pandemic in Spain: Impact According to Autonomous Communities and Hospitals

Worldwide, the COVID-19 pandemic has caused a decline in blood donations, between 30% and 70% in some of the most affected countries. In Spain, during the initial eight weeks after the State of Emergency was decreed on 14 March 2020, in the weekly reports of the Health Ministry, an average decrease of 20% was observed between 11 and week 25 compared with the 2018 donation. We aimed to investigate the impact of the COVID-19 pandemic on blood donations and blood distribution in four autonomous communities, and to explore the evolution of the consumption of blood components (BCs) in ten hospitals of six autonomous communities. We performed a prospective study of grouped cohorts on the donation and distribution of blood in four regional transfusion centers in four autonomous communities in Spain, and a retrospective study of the consumption of blood components in ten hospitals in six autonomous communities. Regarding donations, there was no significant decrease in donations, with differences between autonomous communities, which started between 1 and 15 March 2020 (−11%). The increase in donations in phase II (from 26 May 2020) stands out. Regarding consumption, there was a significant reduction in the consumption of packed red blood cells (RBCs) (24.5%), plasma (45.3%), and platelets (25.3%) in the central period (16 March–10 May). The reduction in the consumption of RBCs was significant in the period from 1–15 March. Conclusions: The COVID-19 pandemic has affected the donation and consumption of BCs.
Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy

(1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aquaflux®, skin-pH-Meter, Corneometer® and an Epsilon® sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants’ skin. Tape strips of treated skin sites were taken and the collected corneocytes were subjected to atomic force microscopy. Circular nano objects were counted, and dermal texture indices were determined. (3) Results: Transepidermal water loss was increased, and skin hydration was decreased after treatment with SDS and LPC80. Natural moisturizing factor and urea concentrations within the outermost 10 µm of the stratum corneum were lower than after treatment with S75 or water. Dermal texture indices of skin treated with SDS were higher than skin treated with water (control). (4) Conclusions: Results suggest very good (S75) or good (LPC80) skin-tolerability of lecithin-based surfactants in comparison to SDS and encourage further investigation.
On the intersection of grating truncation rods with the Ewald sphere studied by grazing‐incidence small‐angle X‐ray scattering

In this work a grating made of lines having a height of 55 nm and a period of 450 nm has been characterized by grazing-incidence small-angle X-ray scattering (GISAXS). The GISAXS patterns are characterized by a series of spots corresponding to the intersection of the Ewald sphere with the grating truncation rods (GTRs). When the grating lines are almost parallel to the direct beam, the location of these spots is very sensitive to any change in the azimuthal angle. The precise location of the intersection of the GTRs with the Ewald sphere can be calculated for any azimuthal angle. From this analysis we can estimate the statistical coverage of the grating, its period and the width of the lines. In addition, the anisotropy of the width of the spots in the qz direction is interpreted in terms of wavelength spread and angular divergence of the incident beam.
Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus

The benefits of a Mediterranean Diet (MedDiet) in the management of diabetes have been reported, but the contribution of polyphenol-rich citrus fruit has not been studied widely. Here, we report the sub-study findings of a previously conducted MedDiet intervention clinical trial in patients with type 2 diabetes mellitus (T2DM), where we aimed to measure the diet intervention effects on plasma citrus bioflavonoids levels and biomarkers of inflammation and oxidative stress. We analysed plasma samples from 19 (of original 27) participants with T2DM who were randomly assigned to consume the MedDiet intervention or their usual diet for 12 weeks and then crossed over to the alternate diet. Compared with baseline, MedDiet significantly increased levels of the citrus bioflavonoids naringin, hesperitin and hesperidin (by 60%, 58% and 39%, respectively, p < 0.05) and reduced plasma levels of the pro-inflammatory cytokine IL-6 (by 49%, p = 0.016). Oxidative stress marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) decreased by 32.4% (p = 0.128). Usual diet did not induce these beneficial changes. The reduced inflammatory profile of T2DM participants may, in part, be attributed to the anti-inflammatory actions of citrus bioflavonoids. Together with indications of improved oxidative stress, these findings add to the scientific evidence base for beneficial consumption of citrus fruit in the MedDiet pattern.
Molecular Dynamics Simulations of a Catalytic Multivalent Peptide–Nanoparticle Complex

Molecular modeling of a supramolecular catalytic system is conducted resulting from the assembling between a small peptide and the surface of cationic self-assembled monolayers on gold nanoparticles, through a multiscale iterative approach including atomistic force field development, flexible docking with Brownian Dynamics and µs-long Molecular Dynamics simulations. Self-assembly is a prerequisite for the catalysis, since the catalytic peptides do not display any activity in the absence of the gold nanocluster. Atomistic simulations reveal details of the association dynamics as regulated by defined conformational changes of the peptide due to peptide length and sequence. Our results show the importance of a rational design of the peptide to enhance the catalytic activity of peptide–nanoparticle conjugates and present a viable computational approach toward the design of enzyme mimics having a complex structure–function relationship, for technological and nanomedical applications.
Practical Synthesis of 2-Iodosobenzoic Acid (IBA) without Contamination by Hazardous 2-Iodoxybenzoic Acid (IBX) under Mild Conditions

We report a convenient and practical method for the preparation of nonexplosive cyclic hypervalent iodine(III) oxidants as efficient organocatalysts and reagents for various reactions using Oxone® in aqueous solution under mild conditions at room temperature. The thus obtained 2-iodosobenzoic acids (IBAs) could be used as precursors of other cyclic organoiodine(III) derivatives by the solvolytic derivatization of the hydroxy group under mild conditions of 80 °C or lower temperature. These sequential procedures are highly reliable to selectively afford cyclic hypervalent iodine compounds in excellent yields without contamination by hazardous pentavalent iodine(III) compound.
Effect of the organic groups of difunctional silanes on the preparation of coated clays for olefin polymer modification

Abstract Sodium montmorillonite (MMT) was organically modified with hexadecyltrimethyl-ammonium ions and subsequently treated with dichlorosilanes and water, aimed at in situ silane condensation polymerization and modification of clay platelets by polysiloxane coatings. Dimethyldichlorosilane, methylphenyldichlorosilane, and diphenyldichlorosilane were used to produce three siloxane-modified organoclays. The structure and morphology of the clay materials were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric studies (TG) and scanning electron microscopy (SEM). XRD results showed that the silanes were effectively polymerized in the clay galleries, forming a nanocomposite of intercalated particles. A fraction of the siloxane formed is bonded to the clay surface by covalent siloxane bonds. Strong structural differences in both morphology and thermal stability of the materials may occur when changing methyl or phenyl groups in the siloxane structure. The formation mechanism of these intercalated nanocomposite particles is considered. Finally, these modified clays were incorporated in an olefin polymer and morphological analyses using transmission electron microscope (TEM) images were carried out.