Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on Technological Divisive Faultlines in Cliques: Evidence From China’s Biomedical Industry Innovation Network

Social identity theory and self-classification theory provide theoretical supports for explaining the formation and action of the technological divisive faultlines. The purpose of this study is to explore the effects of technological divisive faultlines on a clique’s innovation performance and the moderating effects of geographical proximity and closeness centrality. The data of 119 firm alliance and 351 firms in cliques are collected in China’s biomedical industry from 2010-2017. Then, we perform the negative binomial regression by STATA software with these data as samples. The results show that there is an inverted U-shaped relationship between the technological divisive faultlines and clique’s innovation performance; geographical proximity has no moderating effect on the inverted U-shaped relationship; closeness centrality has a significant negative moderating effect on the inverted U-shaped relationship between them. Besides, it suggests that the clique’s innovation performance under high closeness centrality is higher than that under low closeness centrality, which provides a new perspective for the previous research that forming cliques could break the relational redundancy.
Assessing the Relationship between Plasma Von Willebrand Factor Antigen Levels, ABO and Rh (D) Blood Groups and Risk of Sickle Cell Anaemia Vaso – Occlusive Crisis

In sickle cell anaemia (SCA), continuous activation of the vascular endothelium by inflammatory cytokines leads to increased elaboration and secretion of von Willebrand Factor (vWF), a potent mediator of adhesive interactions involving the endothelium and circulating blood cells. Non-O blood groups are associated with the elevation of vWF concentration. Thus, SCA and non – O blood groups are determinants of increased levels of vWF, which plays a pivotal role in the pathophysiology of vaso-occlusive crisis (VOC). To determine the influence of plasma vWF:Ag levels, ABO and Rh (D) blood groups on the risk of occurrence of sickle cell vaso-occlusive crisis. We conducted a prospective study of frequencies of VOC with respect to plasma vWF:Ag levels, ABO and Rh (D) blood groups of 50 SCA patients. In comparison with blood group O, patients with non – O blood groups had significantly higher mean vWF concentration (4.17+3.16 IU/l vs 3.46+3.69 IU/l, p< 0.001), with a significantly higher mean number of VOC episodes per patient (3.2 vs 1.3, p<0.001). The relative risk of VOC for patients with non- O blood groups was 1.87 (95% confidence interval 1.5 - 2.2, p<0.001). However, the association of Rh (D) blood group of the patients and their plasma vWF:Ag levels on the risk of occurrence and frequency of VOC was not statistically significant (P = 0.155). SCA patients with non – O blood groups had more episodes and higher risk of VOC that were likely due to the effect of higher plasma vWF concentration. These results indicate that the non- O blood group is a risk factor for frequent VOC and an unfavourable prognostic marker in SCA. We hereby recommend that a large multicentre prospective study be carried out to definitely determine the impact of ABO, Rh and other blood groups on the overall clinical course of SCA.
Transcriptomic Analysis of Radish (Raphanus sativus L.) Roots with CLE41 Overexpression

The CLE41 peptide, like all other TRACHEARY ELEMENT DIFFERENTIATION INHIBITORY FACTOR (TDIF) family CLE peptides, promotes cell division in (pro-)cambium vascular meristem and prevents xylem differentiation. In this work, we analyzed the differential gene expression in the radish primary-growing P35S:RsCLE41-1 roots using the RNA-seq. Our analysis of transcriptomic data revealed a total of 62 differentially expressed genes between transgenic radish roots overexpressing the RsCLE41-1 gene and the glucuronidase (GUS) gene. For genes associated with late embryogenesis, response to abscisic acid and auxin-dependent xylem cell fate determination, an increase in the expression in P35S:RsCLE41-1 roots was found. Among those downregulated, stress-associated genes prevailed. Moreover, several genes involved in xylem specification were also downregulated in the roots with RsCLE41-1 overexpression. Unexpectedly, none of the well-known targets of TDIFs, such as WOX4 and WOX14, were identified as DEGs in our experiment. Herein, we discuss a suggestion that the activation of pathways associated with desiccation resistance, which are more characteristic of late embryogenesis, in roots with RsCLE41-overexpression may be a consequence of water deficiency onset due to impaired vascular specification.
Time on Therapy of Automated Peritoneal Dialysis with and without Remote Patient Monitoring: A Cohort Study

Background Remote patient monitoring (RPM) of patients undergoing automated peritoneal dialysis (APD-RPM) may potentially enhance time on therapy due to possible improvements in technique and patient survival. Objective To evaluate the effect of APD-RPM as compared to APD without RPM on time on therapy. Methods Adult incident APD patients undergo APD for 90 days or more in the Baxter Renal Care Services (BRCS) Colombia network between January 1, 2017, and June 30, 2019, with the study follow-up ending June 30, 2021. The exposure variable was APD-RPM vs. APD-without RPM. The outcomes of time on therapy and mortality rate over two years of follow-up were estimated in the full sample and in a matched population according to the exposure variable. A propensity score matching (PSM) 1:1 without replacement utilizing the nearest neighbor within caliper (0.035) was used and created a pseudopopulation in which the baseline covariates were well balanced. Fine & Gray multivariate analysis was performed to assess the effect of demographic, clinical, and laboratory variables on the risk of death, adjusting for the competing risks of technique failure and kidney transplantation. Results In the matched sample, the time on APD therapy was significantly longer in the RPM group than in the non-RPM group, 18.95 vs. 15.75 months, p < 0.001. The mortality rate did not differ between the two groups: 0.10 events per patient-year in the RPM group and 0.12 in the non-RPM group, p=0.325. Conclusion Over two years of follow-up, the use of RPM vs. no RPM in APD patients was associated with a significant increase in time on therapy, by 3.2 months. This result indicates that RPM-supported APD therapy may improve the clinical effectiveness and the overall quality of APD.
Analysis of ocean ontologies in three frameworks: A study of law of the sea discourse

Legal frameworks have historically used a colonial territorialist approach to governing ocean space. The United Nations Convention on the Law of the Sea (1982) represents a theoretical departure from colonial territorialism. Instead, UNCLOS employs a functionalist logic approach that is based on principles of sovereignty and consent and uses administrative reasoning as a basis for decision-making. This paper investigates what ontological principles are employed in the development of UNCLOS and asks how these are reproduced in other frameworks. I consider whether ontologies can be extrapolated and studied as latent but agential positions in ocean law and governance frameworks and examine how they might be obstructive to the development of effective regional ocean governance. Lastly, I ask whether ontological principles can be reformed, and through what type of interventions this might be achieved. Results show that tenets of colonial territorialism persist in UNCLOS as terrestrialising practices that are reappropriated towards marine communities. Further, that there are fundamental ways in which ontological principles are obstructive to conservation goals in ocean governance frameworks. Lastly, while the structural reproduction of ontological principles between frameworks resists intervention, evidence suggests that interventionist legal mechanisms that displace anthropocentrisms may offer distinct opportunities for reform.
Distinguishing Genuine Imperial Qing Dynasty Porcelain from Ancient Replicas by On-Site Non-Invasive XRF and Raman Spectroscopy

The combined use of non-invasive on-site portable techniques, Raman microscopy, and X-ray fluorescence spectroscopy on seven imperial bowls and two decorated dishes, attributed to the reigns of the Kangxi, Yongzheng, Qianlong, and Daoguang emperors (Qing Dynasty), allows the identification of the coloring agents/opacifiers and composition types of the glazes and painted enamels. Particular attention is paid to the analysis of the elements used in the (blue) marks and those found in the blue, yellow, red, and honey/gilded backgrounds on which, or in reserve, a floral motif is principally drawn. The honey-colored background is made with gold nanoparticles associated with a lead- and arsenic-based flux. One of the red backgrounds is also based on gold nanoparticles, the second containing copper nanoparticles, both in lead-based silicate enamels like the blue and yellow backgrounds. Tin and arsenic are observed, but cassiterite (SnO2) is clearly observed in one of the painted decors (dish) and in A676 yellow, whereas lead (calcium/potassium) arsenate is identified in most of the enamels. Yellow color is achieved with Pb-Sn-Sb pyrochlore (Naples yellow) with various Sb contents, although green color is mainly based on lead-tin oxide mixed with blue enamel. The technical solutions appear very different from one object to another, which leads one to think that each bowl is really a unique object and not an item produced in small series. The visual examination of some marks shows that they were made in overglaze (A608, A616, A630, A672). It is obvious that different types of cobalt sources were used for the imprinting of the marks: cobalt rich in manganese for bowl A615 (Yongzheng reign), cobalt rich in arsenic for bowl A613 (but not the blue mark), cobalt with copper (A616), and cobalt rich in arsenic and copper (A672). Thus, we have a variety of cobalt sources/mixtures. The high purity of cobalt used for A677 bowl indicates a production after ~1830–1850.
Effect of Silane Coupling Agents on the Rheology, Dynamic and Mechanical Properties of Ethylene Propylene Diene Rubber/Calcium Carbonate Composites

The effects of three trimethoxysilanes with different functional groups on the rheology, dynamic and mechanical properties of ethylene propylene diene rubber (EPDM)/calcium carbonate (CaCO3) composites were investigated respectively. The results showed that the addition of silane increased the value of MH and MH–ML of the compounds. Geniosil XL 33 silane decreased the shear modulus of the EPDM/CaCO3 compounds, and the bound rubber content increased slightly with the addition of vinyl trimethoxy silane (VTMS) and methylacryloxy-methyltrimethoxysilane (Geniosil XL 33) silane in the compounds. The vulcanizates with the addition of the VTMS and Geniosil XL 33 silane showed a significant increase in tensile strength and abrasion resistance; however, ethyltrimethoxysilane (ETMS) silane weakened the tensile strength and abrasion resistance of the vulcanizates. At low strain, the cross-linking and reaggregation of fillers resulted in a high storage modulus of vulcanizates with silane. When the strain exceeded 10%, the storage modulus of the vulcanizates with the Geniosil XL 33 and VTMS silane was higher. The loss modulus and tan δ of the vulcanized rubber with the Geniosil XL 33 and VTMS silanes were lower compared to the ETMS and 0 silane.
Structural and Functional Studies of S-(2-Carboxyethyl)-L-Cysteine and S-(2-Carboxyethyl)-l-Cysteine Sulfoxide

Insecticidal non-proteinogenic amino acid S-(2-carboxyethyl)-L-cysteine (β-CEC) and its assumed metabolite, S-(2-carboxyethyl)-l-cysteine sulfoxide (β-CECO), are present abundantly in a number of plants of the legume family. In humans, these amino acids may occur as a result of exposure to environmental acrylonitrile or acrylamide, and due to consumption of the legumes. The β-CEC molecule is a homolog of S-carboxymethyl-l-cysteine (carbocisteine, CMC), a clinically employed antioxidant and mucolytic drug. We report here detailed structural data for β-CEC and β-CECO, as well as results of in vitro studies evaluating cytotoxicity and the protective potential of the amino acids in renal tubular epithelial cells (RTECs) equipped with reporters for activity of seven stress-responsive transcription factors. In RTECs, β-CEC and the sulfoxide were not acutely cytotoxic, but activated the antioxidant Nrf2 pathway. β-CEC, but not the sulfoxide, induced the amino acid stress signaling, which could be moderated by cysteine, methionine, histidine, and tryptophan. β-CEC enhanced the cytotoxic effects of arsenic, cadmium, lead, and mercury, but inhibited the cytotoxic stress induced by cisplatin, oxaliplatin, and CuO nanoparticles and acted as an antioxidant in a copper-dependent oxidative DNA degradation assay. In these experiments, the structure and activities of β-CEC closely resembled those of CMC. Our data suggest that β-CEC may act as a mild activator of the cytoprotective pathways and as a protector from platinum drugs and environmental copper cytotoxicity.
Fiber to Chip Fusion Splicing for Robust, Low Loss Photonic Packaging

Silicon photonic devices are poised to enter high volume markets such as data-communications, telecommunications, biological sensing, and optical phased arrays; however, permanently attaching a fiber to the photonic chip with high optical efficiency remains a challenge. We present a robust and low-loss packaging technique of permanent optical edge coupling between a fiber and a chip using fusion splicing which is low-cost and scalable to high volume manufacturing. We fuse a SMF-28 cleaved fiber to the chip via CO$_2$ laser and reinforce it with optical adhesive. We demonstrate minimum loss of 1.0dB per-facet with 0.6dB penalty over 160nm bandwidth from 1480nm-1640nm.
A Comparison of Three Types of “Vineyard Management” and Their Effects on the Structure of Plasmopara viticola Populations and Epidemic Dynamics of Grape Downy Mildew

Grape downy mildew (GDM) is a destructive grapevine disease caused by Plasmopara viticola that occurs worldwide. In this study, we determined the characteristics of GDM epidemics and the grapevine canopy micro-climate in open-field, fungicide-spray, and rain-shelter plots during two constitutive years (2016 and 2017). It was found that rain shelter can significantly delay the disease occurrence by 28 and 21 days, reduce the epidemic phase by 28 and 21 days, and decrease the final disease index by 82% and 83%. Furthermore, it can block precipitation, reduce the relative humidity by 11% and 8%, and reduce the leaf wetness duration by 85% and 76% compared with open-field cultivation. A total of 3861, 783, and 1145 lesions were collected from the open-field, fungicide-managed, and rain-shelter plots, respectively, for analyses of the genetic diversity, population differentiation, and epidemic mode with seven microsatellite markers. In terms of genetic diversity, the Nei’s diversity index ranged from 0.569 to 0.680 and Shannon’s information index ranged from 0.958 to 1.226, showing high levels of diversity across populations. Similar to fungicide management, a rain shelter can significantly reduce the population’s genetic diversity. Low pairwise FST values (0.003–0.047) and high gene flow (Nm = 1.548–20.699) were observed among the three populations each year. In addition, most of the genetic variation occurred within populations. The epidemic mode of GDM in the open-field, fungicide-managed, and rain-shelter cultivation showed moderate, low, and high levels of clonality, respectively, in the case study.
COVID-19 Related Emotional Stress and Bedtime Procrastination Among College Students in China: A Moderated Mediation Model

Purpose Although bedtime procrastination is prevalent during the COVID-19 pandemic, little is known about the relationship between COVID-19 related emotional stress and bedtime procrastination. Therefore, we investigated the correlation between COVID-19 related emotional stress and bedtime procrastination and examined the mediating role of negative affect and the moderating role of rumination among Chinese college students. Methods A multicenter, cross-sectional, and quantitative research was conducted in China from August 11, 2021, to August 27, 2021, during the COVID-19 pandemic. The sampling method used in the study is the convenience sampling method. A total of 913 college students (aged 18–24 years) participated and completed online self-reported questionnaires. Their levels of COVID-19 related emotional stress, negative affect, rumination, and bedtime procrastination were measured by the Coronavirus Stress Measure, the Depression Anxiety Stress Scale, the Ruminative Responses Scale, and the Bedtime Procrastination Scale, respectively. The data were analyzed using Pearson correlations and moderated mediation analysis. Results COVID-19 related emotional stress was positively associated with bedtime procrastination. Meanwhile, the association could be mediated by negative affect (Effect = 0.33, Boot 95% CI = [0.26, 0.39]) and moderated by rumination (Effect = 0.05, Boot 95% CI = [0.03, 0.07]) through its moderation in the link between COVID-19 related emotional stress and negative affect. This indicated that the mediation effect of negative affect was stronger in college students with high levels of rumination than in those with low levels of rumination. Conclusion The findings of this study shed light on a correlation between COVID-19 related emotional stress and bedtime procrastination. Moreover, this study suggests that interventions could be targeted at alleviating negative affect and rumination to reduce the bedtime procrastination of college students with high levels of COVID-19 related emotional stress.
Dual Targeting of the EGFR/HER2 Pathway in Combination with Systemic Chemotherapy in Refractory Pancreatic Cancer—The CONKO-008 Phase I Investigation

Background: Primary objective of this present trial was to define the maximum tolerable dose of lapatinib in combination with oxaliplatin, 5-fluorouracil, and folinic acid (OFF) in refractory pancreatic cancer. The secondary objective was to assess the safety and efficacy of lapatinib plus OFF. Methods: We conducted a phase I trial using an accelerated dose escalation design in patients with refractory pancreatic cancer. Lapatinib was given on days 1 to 42 in combination with folinic acid 200 mg/m2 day + 5-fluorouracil 2000 mg/m2 (24 h) on days 1, 8, 15, and 22, and oxaliplatin 85 mg/m2 days 8 and 22 of a 43-day cycle (OFF). Toxicity and efficacy were evaluated. Results: In total, eighteen patients were enrolled: dose level 1 (1000 mg) was assigned to seven patients, dose level 2 (1250 mg), five patients; and dose level 3 (1500 mg), six patients. Dose-limiting toxicities were diarrhea and/or neutropenic enterocolitis observed in two of six patients: one diarrhea III°, one diarrhea IV°, as well as neutropenic enterocolitis. The maximum tolerable dose of lapatinib was 1250 mg OD. Conclusions: The combination of lapatinib 1250 mg OD with platinum-containing chemotherapy is safe and feasible in patients with refractory pancreatic cancer and warrants further investigation.
Advances in the Effects of Biochar on Microbial Ecological Function in Soil and Crop Quality

Biochar, a late-model environmental functional material, has been widely applied in environmental remediation, agricultural production, and energy utilization due to its excellent characteristics such as porosity and high specific surface area. In recent years, many studies on the effects of biochar on agricultural soil and crop quality have been performed. The application of biochar can influence soil microbial status directly or indirectly by changing the physicochemical properties of soil. Apart from increasing soil pH, biochar can also increase soil organic matter and nutrient elements, which ultimately affect crop yield and quality. This review summarizes and overviews the recent research advances on the influence of biochar application on soil microbial community diversity, microbial ecological functions, soil enzymes and their functional genes, and on crop quality and yield from the perspective of soil microorganisms. This review provides guidance and references for further research into biochar applications.
Agglomeration decay in rural areas

Spatial proximity to other economic activities – occasionally labeled as ‘market access’ and ‘economic density’ – is associated with good economic performance. How the impulses from economic activities diminish over space is known as ‘agglomeration decay’ or ‘distance decay’. Although market access functions and the associated agglomeration decay constitute an important topic within spatial economic research, the phenomenon is seldom studies in a rural setting or addressed by non-linear estimation techniques. In this paper, we estimate the market access function in the relatively rural regions of Southern parts of Norway. We approximate market access in the national road network by alternative market access functions with power and exponential distance decay, applying ordinary non-linear least squares (NLS) and non-linear mixed effects (NLME). We apply labor productivity as the outcome variable, employment and population as alternative measures for potential market connections and traveling time as distance measure. In the regression, we control for capital intensity, industry structure and annual growth trend, as well as mixed effect in case of the NLME model. Compared to previous findings in the literature, we find evidence of relative sharp agglomeration decay in a rural setting, involving power and exponential distance decay parameters of about 2.3 and 0.07 respectively. Comparisons of the log likelihood from the estimation of market access functions suggest that exponential distance decay involve a slightly better fit than power distance decay. In addition, employment involves slightly more explanatory power than population as a measure for potential market connections.
Dynamics of long range interacting systems beyond the Vlasov limit

Long range interactions concern numerous natural systems. A notable example is the one of the gravitation which is relevant in the case of the study of a stars system or galaxy clusters. In particular, these systems does not respect the additivity of thermodynamical potential and present a dynamics dominated by collective effects. One of the most remarkable feature is that, after a very rapid evolution, these systems remains trapped into quasi-stationary states up to a very long time (diverging with the system size). It is only on longer time scales, that simulations have shown that the system relaxes to thermal equilibrium.Quasi-stationary states are theoretically interpreted as solutions of the Vlasov equation. This mean filed equation represents a very good approximation of the dynamics of long range systems in the limit of a large number of particles. Firstly we give a limit on the validity of the Vlasov equation depending of the range of the pair force and on its short scales regularisation. In a second part, using theoretical an numerical approach, we study the modification of the dynamics of long range systems when subjected to different kinds of non-Hamiltonian perturbations. In particular, the robustness of quasi-stationary states, in presence of this different perturbations is analysed in details.