Miracle-dz/UniFAR-FTUs huggingface dataset:
CMAR_A_199396 4971..4984

*These authors contributed equally to this work Purpose: The chr1p/19q co-deletion is a favorable prognostic factor in patients with lower grade glioma. The aim of this study was to reveal key genes for prognosis and establish prognostic gene signatures based on genes encoded by chr1p/19q. Materials and methods: The data was downloaded from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA) and Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) between lower grade glioma tissue and normal brain were identified. The univariate COX regression, robust likelihood-base survival analysis (rbsurv) andmultivariate COX regression analysis were used to establish the 4-gene-signature based on the DEGs. The receiver operating characteristic (ROC) curve and the Kaplan-Mere curve were used to verify the prediction accuracy of the signature. Gene Set Enrichment Analysis (GSEA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were also performed to explore the reasons for good prognosis in patients with chr1p/19q deletion. Results: A total of 1346 DEGs were identified between lower grade glioma samples and normal brain samples in GSE16011, including 56 up-regulated mRNAs located on chr1p and 20 upregulated mRNAs located on chr19q. We established a 4-gene-signature that was significantly associated with survival based on the 76 gene. The AUC of the 4-gene-signature for 5-year OS in TCGA and CGGA was 0.837 and 0.876, respectively, which was superior compared to other parameters such as chr1p/19q co-deletion, IDHmutant, WHO grade and histology type, especially in chr1p/19q non-co-deletion patients. GSEA and KEGG analysis suggested that the prolongation of chr1p/19q in patients could be associated with cell cycle and DNA mismatch repairing. Conclusions: We established a robust 4-gene-signature based on the chr1p/19q and we explored the potential function of these newly identified survival-associated genes by bioinformatics analysis. The 4-gene from the signature are promising molecular targets to be used in the future.
Augmented reality with holograms for combat management systems

Technical advancements in 3D projection has recently made presentation of holographic images possible by using self-contained devices. Instead of using a screen to present objects, glasses like Microsoft HoloLens can render objects that appear as holograms around the user. SAAB Defence and Security are evaluating if this new technology can complement their command and control system 9LV Combat Management System. This degree project is a study of the technical possibilities and limitations of introducing holographic display of sonar tracks used for detecting submarines or sea mines. The project was started with a background study into what methods are available to render 3D underwater terrain. A basic hologram representing a map of littoral terrain was constructed and simulated sonar tracks from the command and control system was mapped into the terrain. Implementation of the application was done using the Unity 3D game engine that has built in support for the HoloLens. Performance evaluation was done using Unity3D profiler that is an extensive application evaluation tool that maintain overhead to a minimum. An evaluation of HoloLens usage onboard two different boats was done to conclude if the equipment can be used in the normal 9LV CMS operating environment. Results show that it is possible to successfully use holographic display for sonar tracks, but due to limited processing power of the HoloLens terrain detail will be reduced. Holograms are orientated by combining camera spatial mapping and an inertial measurement unit. Usage tests onboard a vessel indicates that holograms will unexpectedly move and the HoloLens will loose spatial mapping due to acceleration forces caused by seastate.
Genome-wide analysis of stage-specific inbreeding depression in the Pacific oyster Crassostrea gigas

1 Inbreeding depression and genetic load have been widely observed, but their genetic basis 2 and effects on fitness during the life cycle remain poorly understood, especially for marine 3 animals with high fecundity and high, early mortality (Type-III survivorship). A high load of 4 recessive mutations was previously inferred for the Pacific oyster Crassostrea gigas, from 5 massive distortions of zygotic, marker segregation-ratios in F2 families. However, the number, 6 genomic location, and stage-specific onset of mutations affecting viability have not been 7 thoroughly investigated. Here, we again report massive distortions of microsatellite-marker 8 segregation ratios in two F2 hybrid families, but we now locate the causative deleterious 9 mutations, using a quantitative trait locus (QTL) interval-mapping model, and we characterize 10 their mode of gene action. We find 14-15 viability QTL (vQTL) in the two families. Genotypic 11 frequencies at vQTL generally suggest selection against recessive or partially recessive alleles, 12 supporting the dominance theory of inbreeding depression. No epistasis was detected among 13 vQTL, so unlinked vQTL presumably have independent effects on survival. For the first time, 14 we track segregation ratios of vQTL-linked markers through the life-cycle, to determine their 15 stage-specific expression. Almost all vQTL are absent in the earliest life-stages examined, 16 confirming zygotic viability selection; vQTL are predominantly expressed before the juvenile 17 stage (90%), mostly at metamorphosis (50%). We estimate that, altogether, selection on vQTL 18 caused 96% mortality in these families, accounting for nearly all of the actual mortality. Thus, 19 genetic load causes substantial mortality in inbred Pacific oysters, particularly during 20 metamorphosis, a critical developmental transition warranting further investigation. 21
Active Learning in an Environment of Innovative Training and Sustainability. Mapping of the Conceptual Structure of Research Fronts through a Bibliometric Analysis

The present study seeks to map and visualize up-to-date perspectives of the topic of active learning by analyzing and interpreting the different elements that make up learning ecosystems within the European Higher Education Area. With this aim, scientometric methods were employed to analyze a sample of 474 articles recovered from Web of Science (WoS) during the three-year period between 2018 and 2020. All articles examined the topic of active learning.
Renal Morphology in Coronavirus Disease :

Renal biopsy is useful to better understand the histological pattern of a lesion (glomerular, tubulointerstitial, and vascular) and the pathogenesis that leads to kidney failure. The potential impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) on the kidneys is still undetermined, and a variety of lesions are seen in the kidney tissue of coronavirus disease patients. This review is based on the morphological findings of patients described in case reports and a series of published cases. A search was conducted on MEDLINE and PubMed of case reports and case series of lesions in the presence of non‐critical infection by SARS‐CoV‐2 published until 15/09/2020. We highlight the potential of the virus directly influencing the damage or the innate and adaptive immune response activating cytokine and procoagulant cascades, in addition to the genetic component triggering glomerular diseases, mainly collapsing focal segmental glomerulosclerosis, tubulointerstitial, and even vascular diseases. Kidney lesions caused by SARS‐CoV‐2 are frequent and have an impact on morbidity and mortality; thus, studies are needed to assess the morphological kidney changes and their mechanisms and may help define their spectrum and immediate or long‐term impact.
INVESTIGATION OF THE USE OF SCRAP TYRES AS SOIL REINFORCEMENT

Waste tyres, which are produced in every society in numbers that are increasing annually, are impacting the environment and causing serious problems. These materials possess exceptional properties that can be reused as reinforcement materials in the geotechnical engineering industry. This study investigated the effects of tyre shreds that were randomly mixed with sand and clay to enhance their engineering properties. An Atterberg limits analysis, as well as compaction and odometer tests, were performed on china clay with scrap tyres of varying weights (10, 20, 30 and 40%). The results show that the Atterberg limits of clay decrease in proportion to increases in the volume of tyre shreds. The compaction characteristics of clay decreased with increased tyre-shred contents of 2–6 mm and 12 mesh. Compression and recompression indexes increased gradually with the tyre-shred content of 12 mesh. A series of direct shear strength tests were performed on the sand-shredded tyre mixtures of Levenseat sand and concrete sand using a direct shear box of 10 cm x 10 cm. Two relative sizes of shredded tyres, 12 mesh and 2–6 mm, were mixed with sand of different weight percentages. The results showed a general increase in the shear strength parameters of both types of sand with the addition of the shredded tyres. The maximum shear strength was obtained at optimum shredded tyre content, approximately 20% for the 2–6 mm shreds and 15% for the 12-mesh shreds. The results showed that it is possible to use shredded tyres in geotechnical applications.
Structural Defects in Few-Layer Graphene nanostructures syn- thesized by self-propagating high-temperature synthesis

A quantitative method is proposed to determine of Stone-Wales defects for carbon nanostructures with sp2 hybridization of carbon atoms. The technique is based on the diene synthesis reaction (Diels-Alder reaction). The proposed method was used to determine Stone-Wales defects in the few-layer graphene (FLG) nanostructures synthesized by the self-propagating high-temperature synthesis (SHS) process, in reduced graphene oxide (rGO) synthesized based on the method of Hammers and in the single-walled carbon nanotubes (SWCNT) TUBAL trademark, Russia. Our research has shown that the structure of FLG is free of Stone-Wales defects, while the surface concentration of Stone-Wales defects in TUBAL carbon nanotubes is 1.1×10-5 mol/m2 and 3.6×10-5 mol/m2 for rGO.
DMSO_A_306752 2145..2154

1Department of Health Promotion and Behavioral Sciences, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia; 2Department of Health Education and Behavioral Sciences, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia Background: Poor lifestyle choices contribute to the continued growth of chronic illness and disability. Patients with diabetes require continuous self-care choices and management to minimize the shortand long-term impact of the disease. This study aimed at assessing the use of the health belief model to describe self-care practices among patients with diabetes. Methods: An institutional-based cross-sectional study was conducted from February to March 2019 in Gondar City, Northwest Ethiopia. A total of 396 diabetics patients were selected using a systematic random sampling technique. Pretested, structured, and interview administered questionnaire was used for data collection. The collected data were analyzed using STATA 14. Bivariate and multivariate logistic regression models were fitted to identify the factors associated with self-care behavior. Adjusted odds ratio (AOR) with 95% confidence interval (CI) and p-values <0.05 were used to declare statistical association. Results: Health belief model described 48% of the variance in self-care practices of patients with diabetes. More than half (55.6%) of diabetic patients had good self-care practice. Of the participants, 45.8% and 49.9% had low perceived susceptibility and perceived severity, respectively. The strongest correlation was found between cues to action and perceived severity of health belief model constructs (P<0.001). Formal education, longer duration of diabetes, high social support, high perceived severity, and high self-efficacy contributed to good self-care practices, whereas comorbidities, high perceived benefit, and high perceived barrier were associated with poor self-care practices. Conclusion: Self-care practice of diabetes patients in Gondar City was considerably low. Health professionals need to strengthen delivering tailored health messages on the benefit self-care practices and means of overcoming the potential barriers. Health communication programs are also better to consider for individuals with comorbidities, lack of social support, and lower education.
Understanding Clients’ Intentions to Explore Software-as-a-Service (SaaS) Features: A Social Capital Theory Perspective

The pervasive post-adoption of on-demand software-as-a-service (SaaS) products via the Internet has provided clients with sufficient convenience and functional flexibility to rent and build the multifunctional services they require. Prior research has called for a deeper understanding of how client firms encourage the exploration of SaaS applications in the workplace. However, exploring the best service combinations depends on the clients’ socially related motivation. Hence, we draw on social capital theory in this study to examine clients’ intentions to explore new SaaS service features. We use service quality to complement structural capital as an indicator, as it is more suitable for assessing the service structure of systems. Drawing on a sample of 246 employees in the IT service departments of smalland medium-sized companies in Taiwan, we generate the following empirical results. First, most of the main effect paths only show significant positive signs for the effect of relational capital on the intention to explore, and the effect of environmental quality on social capital is not supported. Second, we rebuild the mediation model to test the non-supported hypotheses and find that relational capital partially mediates the relationship between service quality and the intention to explore. The theoretical and practical implications of these findings are discussed.
WATER CONSUMPTION VARIABILITY FOR MAJOR CROPS IN EGYPT UNDER CLIMATE

Khalil A.A. , Y.H. Essa, F.A. Hashem and K.M. Refaie Central Laboratory for Agricultural Climate (CLAC), Agricultural Research Center (ARC), Ministry of Agriculture and Land Reclamation (MALR), Egypt. Manuscript Info Abstract . Manuscript History
The Organizational Outcomes of Computer Supported Cooperative Work Systems: Knowledge Management System Assimilation Study

Knowledge Management System (KMS) has long been examined by Computer Supported Cooperative Work (CSCW) researchers to understand how technologies could support collaborative work and their impacts toward organizations. In this study, we are interested to discover the effects of KMS assimilation in terms of organizational outcomes when the system becomes embedded into the process of collaboration work in a form of Knowledge Management (KM) activities. In fact, the practice of collaborative work in the KM activities form could improve organizational performance, which ultimately contributes to organizational competitive advantage if the system is fully assimilated. However, these relevant benefits of organizational outcomes have not been established in the existing literature. Therefore, we conduct a qualitative research by designing the application of Grounded Theory (GT) to investigate the case study. Data were collected from participants including senior managers, managers, and executives were recruited through criterion and theoretical based purposive sampling. The data collected from three suggested techniques; namely, interviews, observations, and documentations were analyzed according to GT analytical process of data analysis using ATLAS.TI software. The findings reveal two levels of organizational outcomes. The performance efficiency, development of staff proficiency, and responsibility stimulation are the outcomes at the individual level. On the other hand, KM culture, unity establishment, and organizational growth are outcomes at the organizational level.
DMD057513 1110..1116

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, and the limited available treatment options have not meaningfully impacted patient survival in the past decades. Such poor outcomes can be at least partly attributed to the inability of most drugs tested to cross the blood-brain barrier and reach all areas of the glioma. The objectives of these studies were to visualize and compare by matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry the brain and tumor distribution of the phosphatidylinositol 3-kinase (PI3K) inhibitors pictilisib (GDC-0941, 2-(1H-indazol-4-yl)-6-(4methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d] pyrimidine) and GNE-317 [5-(6-(3-methoxyoxetan-3-yl)-7-methyl-4morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine] in U87 and GS2 orthotopic models of GBM, models that exhibit differing bloodbrain barrier characteristics. Following administration to tumor-bearing mice, pictilisib was readily detected within tumors of the contrastenhancing U87 model whereas it was not located in tumors of the nonenhancing GS2 model. In both GBM models, pictilisib was not detected in the healthy brain. In contrast, GNE-317 was uniformly distributed throughout the brain in the U87 and GS2 models. MALDI imaging revealed also that the pictilisib signal varied regionally by up to 6-fold within the U87 tumors whereas GNE-317 intratumor levels were more homogeneous. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) analyses of the nontumored half of the brain showed pictilisib had brain-to-plasma ratios lower than 0.03 whereas they were greater than 1 for GNE-317, in agreement with their brain penetration properties. These results in orthotopic models representing either the contrast-enhancing or invasive areas of GBM clearly demonstrate the need for whole-brain distribution to potentially achieve long-term efficacy in GBM.
RMHP_A_302974 1509..1524

1Department of Midwifery, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia; 2Department of Midwifery, College of Medicine and Health Sciences, Arbaminch University, Arbaminch, Ethiopia; 3Awi Zone Health Office, Amhara Regional State Health Bureau, Bahir Dar, Ethiopia Background: Novel coronavirus 19 is a contagious disease that affects all most all countries of the world and puts the world in great challenge. Even though, there is a limited testing capacity in Africa the number of cases and deaths is progressively increased. This catastrophic case has a great impact in Africa unless preventive measures are effectively undertaken. In Ethiopia, the number of COVID-19 cases and death are increasing over time. Therefore, this study was aimed to assess the level of community readiness for COVID-19 pandemic prevention and its associated factors in residents of Awi Zone, Northwest Ethiopia. Methods: A community-based cross-sectional study design was conducted among 1524 study participants from July 28 to August 27, 2020. Data were collected using structured and pre-tested interviewer-administered questionnaires. The collected data were entered into EPI data 4.6 versions and analyzed using Statistical Package for Social Science (SPSS) version 24.0. Those variables with P-value<0.25 were entered into multivariable analyses and those variables with P-value < 0.05 were considered statistically significant. Finally, the findings of the result were explained using texts, figures, and tables. Results: A total of 1423 participants have participated in the study. The finding revealed that the prevalence of knowledge, attitude, perception, and practice towards COVID-19 were found to be 76.6%, 68.4%, 68.5%, and 29% respectively. In final model, being a female [AOR=1.388 (95% CI: 1.050–1.834) P= 0.021], married respondents [AOR=3.116 (95% CI: 1.592–6.099) P= 0.001], Muslim religion followers [AOR=2.392 (95% CI:1.503–3.806) P=0.002], and able to read and write [AOR=1.986 (95% CI:1.311–3.006) P=0.002] were some of the variables significantly associated with the level of community readiness towards COVID-19 preventive measures. Conclusion: The study findings indicate that respondent’s level of community readiness for COVID-19 prevention was mainly affected by sex, marital status, religion, and educational status. The Health education programs aimed at mobilizing and improving COVID-19 related level of community readiness especially practice are urgently needed. Awareness creation programs on more targeted groups such as men, unmarried and those with low educational level and religious leaders should be teaching the believers by interacting with faith and science on the means of preventing the pandemic.
Do Acquisitions Generate Abnormal Returns? Evidence from the Deregulated Electric Utility Industry

From 1992 onwards, the market for corporate control has been changing as a consequence of deregulation in the North American and West European electric utility industry. Motivated by the lack of consensus on the value creation of acquisitions in the deregulated electric utility industry, this study is conducted. Based on a three and eleven-day event window, cumulative abnormal returns (CARs) of 714 acquisition announcements between 1997 and 2017 stemming from North American and West European acquirers, it is found that acquisitions generate on average an insignificant CAR of 0.2%. West European bidders generate a significant return of 0.94% which outperforms the average CAR of -0.02% stemming from North American bidders. For the aggregate sample, it is found that geographic diversification strategies do not outperform each other and that industry-focussed deals outperform industry-diversified deals. North American managers should avoid cross-border deals within the North American region because these deals destruct shareholder value. West European managers should engage in geographic or industry-focussed deals because it is shown the stock market believes that these type of acquisitions generate synergies.
Spore Wall Maturation

We previously described the use of a differential hybridization screen of a genomic DNA library of Saccharomyces cerevisiae to identify sporulation-specific (SPS) genes (A. Percival-Smith and J. Segall, Mol. Cell. Biol. 4:142-150, 1984). This initial screen identified 14 SPS genes that are first expressed 6 to 8 h after transfer of cells to sporulation medium. Accumulation of transcripts corresponding to these genes becomes maximal at 8 to 12 h of sporulation, the time at which meiotic events are nearing completion, and by 15 h of sporulation, transcript levels are beginning to decrease. In the present study two additional SPS genes, first expressed at 12 h of sporulation, were isolated. The steady-state level of transcripts corresponding to these two genes, termed SPS100 and SPSIOI, remains unchanged from 15 to 35 h, a time coincident with spore wall maturation. The nature of the putative 34.2-kilodalton protein encoded by the SPSIOO gene is consistent with its being a component of the glycoprotein matrix of the spore wall; the protein contains a potential signal sequence and cleavage site and numerous sites for potential glycosylation. A MATa spslOO/MATa spslOO strain was found to be indistinguishable from the wild-type strain when assessed for efficiency of ascus formation and