Miracle-dz/UniFAR-FTUs huggingface dataset:
Multicentric and Observational Study of Omalizumab for Chronic Spontaneous Urticaria in Real-Life in Colombia

Background Although chronic urticaria (CU) is a common, cause of medical consulting both in general practitioners and allergist specialists worldwide, there is little information about its behavior and management in Latin America. Currently, national and international guidelines recommend using Omalizumab for cases refractory to management with antihistamines. Despite advances in the knowledge of Omalizumab for the management of CU, although there are few studies in underdeveloped countries, there are many studies evaluating the impact of Omalizumab treatment. There is not clinical information related with CSU-Omalizumab in patient settled in the Caribbean area. This research aims to evaluate the management of CU with Omalizumab in a real-life scenario in Colombia. Methodology We conducted an observational, descriptive, and retrospective study with patient recruitment between 2014 and 2017 of individuals diagnosed with Chronic Urticaria (CU) treating allergology specialists in five Colombian cities. We included patients with CU who failed to achieve disease control after treatment for 4 weeks with fourfold doses of second-generation H1-antihistamines, as recommended by the EAACI/GA2LEN/EDF/WAO guidelines and who received treatment with Omalizumab. Results We included 123 patients, 73.1% (n = 90) were women. The mean age was 47.1 years (Standard Deviation, SD: 16.2). The median of the total months of disease evolution was 30 (IQR = 13–58). 81.3 % (n = 100) of patients were diagnosed with chronic spontaneous urticarial (CSU). 4.8% (n = 6) had inducible CU (CIndU), and 13.8% (n = 17) reported mixed urticaria (spontaneous CU with at least one inducible component). Regarding emotional factors, 34.9% (n = 43) of subjects indicated anxiety symptoms, 34.1% (n = 42) had exacerbations associated with stress, and 14.6% (n = 18) manifested episodes of sadness. The percentage of patients with CSU controlled according to medical criteria at 3 months with Omalizumab were 80% (n = 80/100) and at 6 months 87% (n = 87/100). The frequency of adverse events was 29.2% (n = 36), with headache being the most frequent adverse event. Conclusions This real-life study with Omalizumab at CU describes percentages of effectiveness and safety similar to those observed in pivotal and real-life studies conducted in other regions around the world.
Identification and Impact Analysis of Family History of Psychiatric Disorder in Mood Disorder Patients With Pretrained Language Model

Mood disorders are ubiquitous mental disorders with familial aggregation. Extracting family history of psychiatric disorders from large electronic hospitalization records is helpful for further study of onset characteristics among patients with a mood disorder. This study uses an observational clinical data set of in-patients of Nanjing Brain Hospital, affiliated with Nanjing Medical University, from the past 10 years. This paper proposes a pretrained language model: Bidirectional Encoder Representations from Transformers (BERT)–Convolutional Neural Network (CNN). We first project the electronic hospitalization records into a low-dimensional dense matrix via the pretrained Chinese BERT model, then feed the dense matrix into the stacked CNN layer to capture high-level features of texts; finally, we use the fully connected layer to extract family history based on high-level features. The accuracy of our BERT–CNN model was 97.12 ± 0.37% in the real-world data set from Nanjing Brain Hospital. We further studied the correlation between mood disorders and family history of psychiatric disorder.
An Update on Protective Effectiveness of Immune Responses After Recovery From COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits variable immunity responses among hosts based on symptom severity. Whether immunity in recovered individuals is effective for avoiding reinfection is poorly understood. Determination of immune memory status against SARS-CoV-2 helps identify reinfection risk and vaccine efficacy. Hence, after recovery from COVID-19, evaluation of protective effectiveness and durable immunity of prior disease could be significant. Recent reports described the dynamics of SARS-CoV-2 -specific humoral and cellular responses for more than six months in convalescent SARS-CoV-2 individuals. Given the current evidence, NK cell subpopulations, especially the memory-like NK cell subset, indicate a significant role in determining COVID-19 severity. Still, the information on the long-term NK cell immunity conferred by SARS-CoV-2 infection is scant. The evidence from vaccine clinical trials and observational studies indicates that hybrid natural/vaccine immunity to SARS-CoV-2 seems to be notably potent protection. We suggested the combination of plasma therapy from recovered donors and vaccination could be effective. This focused review aims to update the current information regarding immune correlates of COVID-19 recovery to understand better the probability of reinfection in COVID-19 infected cases that may serve as guides for ongoing vaccine strategy improvement.
Entry Guidance Law Design for Lunar Return Crew Module

Aiming at entry guidance mission of a mooncraft with the second universe velocity more or less,the reentry guidance law which meets various constraints,including G-load,heating and landing site location constraints,was studied. The lunar return crew module is a ballistic-lift vehicle with low lift-to-drag ratio,the strategy calls for controlling the trajectory by modulation of the magnitude and sign of the vehicle's bank angle. The determination of the magnitude of bank angle was formulated as a nonlinear univariante root finding problem,while the sign of the angle was dependent upon the reversals in accordance with the lateral corridor,which was treated as a function of velocity. Integrated dispersions Monte Carlo simulations were performed to evaluate the performance of the proposed approach,and the results show that the downrange standard deviation is about 30 km,and the cross range standard deviation is smaller than 5 km. In addition,the working factors on bank rate are analyzed,and the relation between the feedback gain factor regulation and guidance precision is proposed.
Experiment study on the burning characteristics of 100 aviation gasoline pool fire

This paper is mainly engaged in the study of the combustion characteristics of 100 aviation gasoline pool fire through experiments and theoretical analysis. As is known, pool fire caused by the fuel leakage is a typical source of disaster in chemical industry. Therefore, it is necessary to study its combustion characteristics of the fire in different sizes it may lead to, including burning rate, heat-release rate, thermal radiation properties and flame pulsation. Therefore, in proceeding with our research, we have established a system for tracing the pool fire combustion characteristics in different scales with heat release rate experimental platform of the Slate Key Laboratory of Fire Science. The experimental results enable us to gain the burning rate of gasoline pool fire by real-time data gathering by means of electronic balance. Meanwhile, ISO 9705 heat-releasing rate measurement system has confirmed the heat release rate. When CCD camera was used to capture the flame, we have succeeded in eslablishing -image processing device for analyzing the flame pulsation. We got thermal radiation characteristics through the flame heal flux arranged in a certain distance off the pool. The experiment results we have gained show that the burning characteristics of such gasoline pool fire of different sizes under study may include burning rate, heal release rate, thermal radiation properties as well as the flame pulsation. The experiment indicates that steady burning rate tends to be greater than the theoretical value of the regular gasoline, whereas the maximum burning rate and attenuation factor prove to be greater than the literature value of regular gasoline. However, the heat release rate of small-size pool proves instable whereas the heat release rate turns to be more and more stable with the increase of the oil pool size. In addition, the flame pulsation becomes so obvious that the flame can be divided into continuous and intermittent sections. While the experimental pulse frequency turns to become in conformity with the formula predicted value by Pagni, strong pool fire flame turbulence lead to a stronger pulse. As the curve comes up with the use of custom fitting function, the parameter values of the formula should be equivalent to a linear relation with the diameter, which helps us to gain the uniform equation of the gasoline pool fire radiation through the said relation.
The effect of forepole reinforcement on tunnelling-induced movements in clay

The research concerns the effects of a Forepoling Umbrella System (FUS) that comprises steel pipes installed in a canopy shape above a tunnel heading to reduce ground movements induced by tunnelling. As an in tunnel reinforcement measure, FUS is known to be beneficial in reducing soil deformations at source and has been used in a number of projects. An extensive literature review was provided covering the framework of tunnelling-induced soil movements and current understanding of the FUS. That highlighted deficiencies in how key parameters of a FUS can be combined to produce effective support. The aim of the research was to investigate the relative effect of the system parameters to gain a clearer insight into achieving an optimal design of a FUS.
PENGARUH PENGGUNAAN STIMULAN GAS TERHADAP PRODUKSI DAN KARAKTER FISIOLOGI KLON BPM 24

Penggunaan stimulan seperti etefon atau gas etilen telah banyak diterapkan terutama pada perkebunan karet untuk meningkatkan produksi lateks. Mekanisme kerja stimulan yang berbahan aktif etefon dalam tanaman karet yakni terdekomposisi menjadi etilen, asam hidroklorit, dan asam fosfat. Stimulan dengan bahan aktif etefon berpengaruh tidak langsung, peningkatan produksi hanya mencapai kurang dari 50%. Sementara itu stimulan dengan bahan aktif berupa gas etilen diabsorbi langsung oleh batang tanaman karet dengan jumlah yang lebih banyak. Penelitian bertujuan untuk mengetahui pengaruh frekuensi sistem stimulan gas terhadap produksi, karakter fisiologi, pertumbuhan vegetatif, dan kepekaan terhadap kering alur sadap. Frekuensi stimulan yang tepat dan optimum akan memberikan produksi tinggi, tanpa menimbulkan efek negatif terhadap metabolisme sel lateks. Penelitian dilaksanakan di Kebun Percobaan Balai Penelitian Sembawa mulai Oktober 2010 sampai September 2011. Penelitian disusun berdasarkan Rancangan Acak Kelompok dengan 5 perlakuan sistem sadap dan 4 ulangan, menggunakan klon BPM 24 tahun tanam 1997 berumur 13 tahun. Penyadapan telah dilakukan sejak 2002 dengan sistem sadap S/2 d3 ET2,5% 10/y(m). Perlakuan antara lain S/4 U d3 6d/7 ETG 40/y (w), S/4 U d3 6d/7 ETG 20/y (2w), S/4 U d3 6d/7 ETG 10/y (m), S/4 U d3 6d/7 ET2,5% 40/y (w), dan S/4 U d3 6d/7 ET2,5% 20/y (2w). Hasil penelitian menunjukkan dengan frekuensi stimulan gas yang tepat diharapkan, produksi tanaman karet dapat ditingkatkan tanpa menimbulkan pengaruh yang negatif terhadap kesehatan tanaman. Stimulan gas dapat meningkatkan produksi sebesar 66,1-76,2% dibanding S/4 U d3 6d/7 ET2,5% 20/y (2w). Berdasarkan hasil pengamatan terhadap produksi, kondisi fisiologis, dan kesehatan tanaman, pengisian gas ke dalam aplikator dilakukan setiap 2 minggu dan panel dipindahkan setiap 3 bulan untuk menghindari menurunnya produksi akibat “kelelahan” panel sadap. Diterima : 17 Juli 2012; Disetujui : 20 September 2012 How to Cite : Herlinawati, E. , & Kuswanhadi. (2012). Pengaruh penggunaan stimulan gas terhadap produksi dan karakter fisiologi klon BPM 24. Jurnal Penelitian Karet, 30 (2), 100-107. Retrieved from http://ejournal.puslitkaret. co.id/index.php/jpk/article/view/126
Occupant behavior lifestyles in a residential nearly zero energy building: Effect on energy use and thermal comfort

Occupant behavior is one of the most significant driving factors of uncertainty in the prediction of building energy use. Large performance gaps have been individuated between residential buildings with the same properties and similar climate conditions. Comfort criteria settings by the occupants and their interaction with the envelope and the systems directly affect the operation of buildings and related energy uses. This study employs building simulations to demonstrate the potential impact of occupant behavior lifestyles and different household compositions on energy use and thermal comfort conditions in a residential nearly zero energy building under-construction. In detail, occupant behavior was classified into three lifestyles: low consumer, standard consumer, and high consumer. The analysis considered energy-related behavioral patterns (regulation of heating and cooling set-points, energy use for equipment, lighting and domestic hot water, ventilation rates, regulation of window blinds) and highlighted key variables, which need to be addressed by decision-makers of behavioral change programs for conscious use of nearly zero energy buildings. While predictive studies concerning energy performance investigated mainly nearly zero energy building models that addressed the optimization of the building features themselves, this research reveals the urgent need of reference models related to human behavioral issues.
Malignant Cells in Urine Cytology: Not Always High-Grade Urothelial Carcinoma

Abstract The main purpose of urine cytology is the detection of high-grade urothelial carcinoma (HGUC). When malignant cells of nonurothelial origin are present, it is often misdiagnosed as HGUC due to the rarity of this event and difficulty in distinguishing subtle cytomorphologic differences. To arrive at the appropriate diagnosis, evaluation of urine cytology specimens requires correlation with clinical and radiologic findings and utilization of cytologic-histologic correlation. We present the case of a 64-year-old woman with gross hematuria. Imaging located an infiltrative mass involving the left renal pelvis, highly suggestive of urothelial carcinoma. Lymphadenopathy and multiple bony lesions in the spine were concerning for metastatic disease. Urine cytology specimens taken during cystoscopy contained malignant cells, which were interpreted as HGUC. The workup of a subsequent lymph node biopsy showed a metastatic high grade carcinoma of renal origin with SMARCB1 loss. This finding led to the reexamination of the urine cytology specimens, revealing the malignant cells were not HGUC but rather renal carcinoma. This case highlights a potential pitfall in the evaluation of urine cytology and the importance of cytologic-histologic correlation.
3d urban modeling from city-scale aerial lidar data

3D reconstruction from point clouds is a fundamental problem in both computer vision and computer graphics. As urban modeling is an important reconstruction problem that has various significant applications, this thesis investigates the complex problem of reconstructing 3D urban models from aerial LiDAR (Light Detection And Ranging) point cloud. In the first part of this thesis, an automatic urban modeling system is proposed which consists of three modules: (1) the classification module classifies input points into trees and buildings; (2) the segmentation module splits building points into different roof patches; (3) the modeling module creates building models, ground, and trees from point patches respectively. In order to support city-scale data sets, this pipeline is extended into an out-of-core streaming framework. By storing data as stream files on hard disks and using main memory as only a temporary storage for ongoing computation, an efficient out-of-core data management is achieved. City-scale urban models are successfully created from billions of points with limited computing resource. The second part of this thesis explores the 2.5D nature of building structures. The 2.5D characteristic of building models is observed and formally defined as "building structures are always composed of complex roofs and vertical walls". Based on this observation, a 2.5D geometry representation is developed for the building structures, and used to extend a classic volumetric modeling approach into a 2.5D method, named 2.5D dual contouring. This algorithm can generate building models with arbitrarily shaped roofs while keeping the verticality of the walls. The next research studies the topology of 2.5D building structures. 2.5D building topology is formally defined as a set of roof features, wall features, and point features; together with the associations between them. Based on this research, the topology restrictions in 2.5D dual contouring are relaxed. The resulting model contains much less triangles but similar visual quality. To further capture the global regularities that intrinsically exist in building models because of human design and construction, a broad variety of global regularity patterns between 2.5D building elements are explored. An automatic algorithm is proposed to discover and enforce global regularities through a series of alignment steps, resulting in 2.5D building models with high quality in terms of both geometry and human judgement. Finally, the 2.5D characteristic of building structures is adopted to aid 3D reconstruction of residential urban areas: a more powerful classification algorithm is developed which adopts an energy minimization scheme based on the 2.5D characteristic of building structures. This thesis demonstrates the effectiveness of all the algorithms on a range of urban area scans from different cities; with varying sizes, density, complexity, and details.
Effect of feeding organic acid treated maize (Zea mays L.) on growth and reproduction of albino rats (Rattus nOTJ'egicus aJbinicus) sDd Indian desert gerbils (Meriones

The organic, acetic and sorbic acids al I % level were fed to albino rats and Indian desert gerbils in whole and broken maize corn. The gerbils were highly sensitive to maize treated with organic acids. The reproduction studies showed that the gerbils had more number of abnormalities with regard to the young oncs. The sorbic acid treated maize possessed a teratogenic potential and it induced cannibalism. In case of albino rats no such abnormaliues were found. However. abortion, delayed gestation period and cannibalism were common. Based on the data obtained it was postulated that the gerbil'! could be used as alternatives to albino rats in toxicological studies.
Simulation of Diffusion-Controlled Growth of Interdependent Nuclei under Potentiostatic Conditions

The problem of diffusion-controlled growth following an instantaneous nucleation event was studied within the framework of a new numerical model, considering the spatial distribution of hemispherical nuclei on the electrode surface and the mutual influence of growing nuclei via the collision of 3D diffusion fields. The simulation of the diffusion-controlled growth of hexagonal and random ensembles was performed at the overpotential-dependent number density of nuclei. The diffusion flow to each nucleus within a random ensemble was simulated by the finite difference method using the derived analytical expressions for the surface areas and the volumes formed at the intersection of 3D diffusion fields with the side faces of a virtual right prism with a Voronoi polygon base. The implementation of this approach provides an accurate calculation of concentration profiles, time dependences of the size of nuclei, and current transients. The results, including total current density transients, growth exponents, and nucleus size distribution, were compared with models developed within the concept of planar diffusion zones, the mean-field approximation and the Brownian dynamics simulation method, as well as with experimental data from the literature. The prospects of the model for studying the initial stages of electrocrystallization were discussed.
Soluble suppression of tumorigenesis-2 is a strong predictor of all-cause, cardiovascular and infection-related mortality risk in haemodialysis patients with diabetes mellitus

ABSTRACT Background Soluble suppression of tumorigenesis-2 (sST2) is a strong prognostic biomarker of cardiovascular (CV) disease. End-stage kidney disease (ESKD) patients are at high risk of CV events and infections. Herein we investigated the utility of sST2 to predict all-cause and cause-specific mortality in haemodialysis (HD) patients with diabetes mellitus. Methods sST2 concentrations were measured in plasma samples of 1196 participants of the German Diabetes and Dialysis (4D) study who had type 2 diabetes mellitus and received maintenance HD for ESKD. Hazard ratios (HRs) for prespecified, adjudicated endpoints were determined according to sST2 levels at baseline by multivariate Cox proportional hazards analysis. Results Participants (mean age 66 years, 54% male) had a median sST2 concentration of 25 ng/mL and were followed up for 4 years. After adjustment for possible confounders, participants with sST2 concentrations in the highest (>32.6 ng/mL) compared with the lowest (<20.1 ng/mL) quartile exhibited a 2-fold higher all-cause mortality risk {[HR 2.06 95% confidence interval (CI) 1.61–2.61]; P < . 001}. High sST concentrations (fourth versus first quartile) were strongly associated with the risk of cardiac death [HR 2.29 (95% CI 1.55–3.39); P < . 001]. Analysis of individual components of cardiac causes of death showed an increased risk of sudden death [HR 2.24 (95% CI 1.33–3.77); P < . 001], death due to myocardial infarction [HR 2.12 (95% CI 0.9–5.0); P = . 087] and heart failure [HR 3.34 (95% CI 1.15–9.75); P = . 027] in participants with sST2 levels in the highest compared with the lowest quartile. Likewise, participants with the highest sST2 levels had an increased risk of fatal stroke [HR 1.92 (95% CI 1.17–3.14); P = . 009] and fatal infections [HR 2.01 (95% CI 1.2–3.37); P = . 008]. In contrast to fatal CV events, sST2 was not associated with the risk of non-fatal myocardial infarction [HR 0.68 (95% CI 0.41–1.12); P = . 132] or non-fatal stroke [HR 1.28 (95% CI 0.64–2.53); P = . 485]. Conclusions In HD patients with diabetes mellitus, high concentrations of sST2 were strongly and independently associated with an increased risk of all-cause mortality, CV mortality and death due to infection but not non-fatal CV events.
Closed Loop Integrated Lighting and Daylighting Control for Low Energy Buildings

Lighting consumes as much as 38% of the total electrical energy in commercial buildings in the United States and higher percentage in emerging economies such as China and India. It is therefore imperative to deploy energy-efficient lighting strategies to realize low-energy sustainable buildings. In addition to high efficiency light sources and fixtures, a variety of control approaches have been explored, including occupancy sensing, daylight harvesting, automated motorized shades, user adaptive control, scheduling and light level tuning. The deployment of these strategies is increasing, albeit at a slow pace. While these technologies provide substantial energy efficiency, further gains in energy savings and comfort can be achieved through the use of integrated controls of daylight and electric lights. In this paper, the benefits of closed-loop integrated controls of daylight and electric lights over other technologies are presented. In particular, simulated and experimental results from a test bed are presented for the following control scenarios: open-loop and closed-loop independent control of window blinds; closed-loop independent control of electric lighting, and closed-loop integrated control of blinds and lighting. It will be shown that under a variety of conditions, closed loop integrated control results in the highest energy savings. Furthermore, simulation results using EnergyPlus will also show the impact of optimized closed loop integrated control of daylight and electric light on cooling and heating load reduction in buildings.