Miracle-dz/UniFAR-FTUs huggingface dataset:
Socioeconomic inequality in compliance with precautions and health behavior changes during the COVID-19 outbreak: an analysis of the Korean Community Health Survey 2020

OBJECTIVES This study examined socioeconomic inequalities in compliance with precautions and health behavior changes during the coronavirus disease 2019 (COVID-19) outbreak using a representative Korean sample. METHODS This exploratory study utilized around 210,000 participants aged ≥25 years in the Korean Community Health Survey 2020. Socioeconomic status was measured with educational attainment and household income. Outcomes included non-compliance with 8 precaution measures and deterioration in 6 health behaviors. The relative inequality index (RII) was calculated to quantify the degree of inequality by education and income level. RII values >1.0 indicate that deprived people have a higher frequency of health problems, and RII values <1.0 conversely indicate a higher frequency of health problems in more advantaged groups. RESULTS People with lower education or income levels tended to have higher rates of non-compliance with COVID-19 safety precautions (RII range, 1.20 to 3.05). Lower education and income levels were associated with an increased smoking amount (RII=2.10 and 1.67, respectively) and sleep duration changes (RII=1.21 and 1.36, respectively). On the contrary, higher education and income levels were associated with decreased physical activity (RII=0.59 and 0.77, respectively) and increased delivery food consumption (RII=0.27 and 0.37, respectively). However, increased alcohol drinking was associated with lower education and income levels in younger men (RII=1.73 and 1.31, respectively), but with higher levels in younger women (RII=0.73 and 0.68, respectively). CONCLUSIONS Our findings suggest the need to develop customized strategies, considering the characteristics of the target population, to decrease the burden and impact of the COVID-19 outbreak.
Nerve transfer with 3D-printed branch nerve conduits

Abstract Background Nerve transfer is an important clinical surgical procedure for nerve repair by the coaptation of a healthy donor nerve to an injured nerve. Usually, nerve transfer is performed in an end-to-end manner, which will lead to functional loss of the donor nerve. In this study, we aimed to evaluate the efficacy of 3D-printed branch nerve conduits in nerve transfer. Methods Customized branch conduits were constructed using gelatine-methacryloyl by 3D printing. The nerve conduits were characterized both in vitro and in vivo. The efficacy of 3D-printed branch nerve conduits in nerve transfer was evaluated in rats through electrophysiology testing and histological evaluation. Results The results obtained showed that a single nerve stump could form a complex nerve network in the 3D-printed multibranch conduit. A two-branch conduit was 3D printed for transferring the tibial nerve to the peroneal nerve in rats. In this process, the two branches were connected to the distal tibial nerve and peroneal nerve. It was found that the two nerves were successfully repaired with functional recovery. Conclusions It is implied that the two-branch conduit could not only repair the peroneal nerve but also preserve partial function of the donor tibial nerve. This work demonstrated that 3D-printed branch nerve conduits provide a potential method for nerve transfer.
Association between paracetamol use during pregnancy and perinatal outcomes: Prospective NISAMI cohort

Background Paracetamol is widely used to manage fever and pain during pregnancy worldwide. However, paracetamol may affect the pregnant woman and fetus, once this drug crosses the placental barrier after therapeutic doses and may impair fetal liver function, affecting fetus growth and development. Thus, this study aimed to investigate the association between paracetamol use during pregnancy and perinatal outcomes as preterm birth, low birth weight, and small for gestational age. Methods and findings Data from 760 pregnant women within the NISAMI Cohort between June 2012 and February 2014 were analyzed. Logistic regression was used to estimate the association among paracetamol use during pregnancy and preterm birth, low birth weight, and small for gestational age. Multivariate analyses were adjusted for socioeconomic, maternal, pregnancy, and newborn covariates. Around 14% of women were exposed to paracetamol during pregnancy. A decrease in paracetamol use throughout pregnancy was observed. Lower risk of low birth weight in infants born to women exposed to the drug (OR 0.21; IC 95% 0.01–0.99) was found. Paracetamol use during pregnancy was not statistically associated with preterm birth or small for gestational age. Conclusions The findings of this study do not suggest an increased risk of perinatal outcomes. However, it should not be assumed that paracetamol is a risk-free medication and its use must be rational.
Prognostic and predictive impact of neutrophil‐to‐lymphocyte ratio and HLA‐I genotyping in advanced esophageal squamous cell carcinoma patients receiving immune checkpoint inhibitor monotherapy

Immune checkpoint inhibitors (ICIs) have become standard‐of‐care in patients with pretreated advanced esophageal squamous cell carcinoma (ESCC). However, reliable biomarkers for clinical outcomes are lacking for ICIs. The exploration of effective biomarkers is therefore needed to optimize patient benefit in the treatment of ESCC.
Coherent Architecture Development as a Basis for Technology Development

A common approach for developing such a technology includes exploration of what the sub-system that carries the technology is, how the sub-system is produced, and how it can be used in new products by means of early prototypes. Developing the prototypes will help identify the needs and requirements to which the technology must prove successful. This coherence between product subsystem, production, and testing in prototypes is essential for identifying the critical areas for development.
Assessment of Community-Level Vulnerability and Access to Medications for Opioid Use Disorder

Key Points Question Does the association of community vulnerability to disasters and pandemics with access to medications for opioid use disorder vary across urban and rural communities? Findings In this cross-sectional study of 32 604 zip codes tabulation area across the continental United States, communities with greater social vulnerability did not have greater geographic access to medications, and the mismatch was greatest in suburban communities. Rural communities had poor geographic access regardless of vulnerability. Meaning These findings suggest that disaster preparedness planning should include anticipation of access to medications for opioid use disorder and better match the location of services to communities with greater vulnerability to prevent inequities in opioid overdose deaths.
Investigation of fungal biomolecules after Low Earth Orbit exposure: a testbed for the next Moon missions

Summary The Moon is characterized by extremely harsh conditions due to ultraviolet irradiation, wide temperature extremes, vacuum resulting from the absence of an atmosphere and high ionizing radiation. Therefore, its surface may provide a unique platform to investigate the effects of such conditions. For lunar exploration with the Lunar Gateway platform, exposure experiments in Low Earth Orbit are useful testbeds to prepare for lunar space experiments and to understand how and if potential biomarkers are influenced by extra‐terrestrial conditions. During the BIOMEX (BIOlogy and Mars EXperiment) project, dried colonies of the fungus Cryomyces antarcticus grown on Lunar Regolith Analogue (LRA) were exposed to space conditions for 16 months aboard the EXPOSE‐R2 payload outside the International Space Station. In this study, we investigated the stability/degradation of fungal biomarkers in LRA after exposure to (i) simulated space and (ii) real space conditions, using Raman spectroscopy, gas chromatography–mass spectrometry and DNA amplification. The results demonstrated that fungal biomarkers were detectable after 16 months of real space exposure. This work will contribute to the interpretation of data from future biological experiments in the Cislunar orbit with the Lunar Gateway platform and/or on the lunar surface, in preparation for the next step of human exploration.
Embryo biotechnologies in sheep: Achievements and new improvements

Abstract To date, large‐scale use of multiple ovulation and embryo transfer (MOET) programmes in ovine species is limited due to unpredictable results and high costs of hormonal stimulation and treatment. Therefore, even if considered reliable, they are not fully applicable in large‐scale systems. More recently, the new prospects offered by in vitro embryo production (IVEP) through collection of oocytes post‐mortem or by repeated ovum pick‐up from live females suggested an alternative to MOET programmes and may be more extensively used, moving from the exclusive research in the laboratory to field application. The possibility to perform oocytes recovery from juvenile lambs to obtain embryos (JIVET) offers the great advantage to significantly reduce the generation interval, speeding the rate of genetic improvement. Although in the past decades several studies implemented novel protocols to enhance embryo production in sheep, the conditions of every single stage of IVEP can significantly affect embryo yield and successful transfer into the recipients. Moreover, the recent progresses on embryo production and freezing technologies might allow wider propagation of valuable genes in small ruminants populations and may be used for constitution of flocks without risks of disease. In addition, they can give a substantial contribution in preserving endangered breeds. The new era of gene editing might offer innovative perspectives in sheep breeding, but the application of such novel techniques implies involvement of specialized operators and is limited by relatively high costs for embryo manipulation and molecular biology analysis.
Exploring the Perceived and the Actual Written Feedback Preferences between Elf Students And Teachers in the UAE

This study aimed at exploring the perceived and the actual written feedback preferences between EFL students and teachers in the UAE. To achieve this aim a convergent parallel mixed-method research design was employed. The quantitative means featured self-report questionnaires for both teachers and students regarding their different types of feedback preferences. Teachers of cycle 3 (n=67) and eleventh grade students (n=116) in public schools participated in this study. Moreover, the qualitative means were collected through interviews which were conducted with teachers (n=23) and students (n=22) who were selected from the initial pool of both samples. Additionally, 28 documents from actual written feedback by teachers were incorporated for in-depth analysis to investigate the actual feedback provided by the teachers. Results of the study revealed that there were more similarities than variations among the teachers and students’ feedback preferences. Moreover, there were some variations among teachers’ perceived preferences and their actual practices of feedback provision. Furthermore, the students’ preferences aligned with their teachers actual practices. Additionally, when the teachers interviewed, the teachers revealed some factors that affect the use of feedback, such as schools’ demands and orientations regarding feedback, students’ proficiency levels and the nature of tasks and lessons objectives. Students viewed direct correction as viable option for them but it is not necessary needed with easy and simple tasks errors. The study offered some recommendations for teachers, curriculum planning, instruction and research.
Light-Emitting Diode (LED) Phototherapy versus Non-LED Phototherapy Devices for Hyperbilirubinemia in Neonates: A Systematic Review and Meta-analysis

Abstract This review was conducted to evaluate the efficacy of light-emitting diode (LED) phototherapy as compared with the conventional phototherapy in neonates with unconjugated hyperbilirubinemia and their adverse effects. We searched the following databases right from their inception till April, 2021: MEDLINE, EMBASE, Cochrane Library, and LILACS. Randomized clinical trials (RCTs) comparing the LED phototherapy with other light sources, which enrolled newborns (term and preterm) with unconjugated hyperbilirubinemia were included. We included 21 articles in this review. The treatment with the LED light therapy had a lower failure rate as compared with the non-LED one (RR = 0.60, 95% CI: 0.39–0.94). The mean duration of phototherapy was significantly shorter in the group with the LED light source as compared with the one with the non-LED light source (mean difference [hours]: −8.07, 95% CI: −8.45 to −7.68), regardless of the type of non-LED units. However, the rate of bilirubin showed a comparable decline (mean difference [mg/dL/h]: 0.01, 95% CI: −0.00, 0.03) in both the light sources, irrespective of irradiance or distance. No studies reported primary outcomes related to the neurotoxicity effects of hyperbilirubinemia in neonates. The LED light devices caused a significantly higher risk of hypothermia. Neonates were at a lower risk of developing hyperthermia and skin rash with the LED light therapy. Our findings provide support for the use of LED light source phototherapy due to its better clinical efficacy, which is evidenced by its shorter duration and lower rate of treatment failure, as compared with the non-LED light sources. Key Points The efficacy of phototherapy is dependent on specific characteristics of light sources of phototherapy devices. LED phototherapy demonstrated better efficacy with shorter duration and lower rate of treatment failure. Adverse effects of phototherapy devices such as hypothermia, hyperthermia, and skin rash should be monitored.
Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events

Abstract Background HDL is endowed with several metabolic, vascular, and immunoinflammatory protective functions. Among them, a key property is to promote reverse cholesterol transport from cells back to the liver. The aim of this study was to estimate the association of scavenger receptor class B type I (SR-BI)- and ATP binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux (the two major routes for cholesterol efflux to HDL) with the presence, extent, and severity of coronary artery disease (CAD), vascular wall remodelling processes, coronary plaque characteristics, and the incidence of myocardial infarction in the different subgroups of patients from the CAPIRE study. Methods Patients (n = 525) from the CAPIRE study were divided into two groups: low-risk factors (RF), with 0–1 RF (n = 263), and multiple-RF, with ≥2 RFs; within each group, subjects were classified as no-CAD or CAD based on the segment involvement score (SIS) evaluated by coronary computed tomography angiography (SIS = 0 and SIS > 5, respectively). SR-BI- and ABCA1-mediated cholesterol efflux were measured using the plasma of all patients. Results SR-BI-mediated cholesterol efflux was significantly reduced in patients with CAD in both the low-RF and multiple-RF groups, whereas ABCA1-mediated cholesterol efflux was similar among all groups. In CAD patients, multivariable analysis showed that SR-BI-mediated cholesterol efflux <25th percentile predicted cardiovascular outcome (odds ratio 4.1; 95% CI: 1.3–13.7; p = .019), whereas ABCA-1-mediated cholesterol efflux and HDL-C levels significantly did not. Despite this finding, reduced SR-BI-mediated cholesterol efflux was not associated with changes in high-risk plaque features or changes in the prevalence of elevated total, non-calcified, and low-attenuation plaque volume. Conclusion SR-BI-mediated cholesterol efflux capacity is lower in patients with diffuse coronary atherosclerosis. In addition, a lower SR-BI-mediated cholesterol efflux capacity is associated with the worst clinical outcomes in patients with CAD, independently of atherosclerotic plaque features. Key Messages Increased cholesterol efflux capacity, an estimate of HDL function, is associated with a reduced CVD risk, regardless of HDL-C levels. HDL-C levels are significantly lower in patients with CAD. Lower SR-BI-mediated cholesterol efflux capacity is observed in patients with diffuse coronary atherosclerosis and is associated with the worst clinical outcomes in patients with CAD, independently of atherosclerotic plaque features.
Seasonal Variation of Physical Performance, Bilateral Deficit, and Interlimb Asymmetry in Elite Academy Soccer Players: Which Metrics Are Sensitive to Change?

Abstract Bishop, C, Abbott, W, Brashill, C, Loturco, I, Beato, M, and Turner, A. Seasonal variation of physical performance, bilateral deficit, and interlimb asymmetry in elite academy soccer players: Which metrics are sensitive to change? J Strength Cond Res 37(2): 358–365, 2023—This study aimed to report seasonal variations for (a) physical performance, (b) interlimb asymmetry, and (c) bilateral deficit (BLD) data over the course of a competitive soccer season and determine which metrics are sensitive to change. This study used a repeated-measures observational design for 19 under-20, elite, academy, soccer players (age: 17.58 ± 0.61 years; height: 1.81 ± 0.09 m; body mass: 74.36 ± 7.58 kg), who conducted bilateral and single-leg countermovement jumps (CMJ and SLCMJ), linear speed (5, 10, 20, and 30-m) and 505 change of direction (COD) speed tests, at pre, mid, and end of season time points. For jump tests, jump height, reactive strength index modified, time to takeoff, and countermovement depth metrics were monitored, with interlimb asymmetry and the BLD also calculated for each. Significant improvements (p < 0.05) in performance were evident in all fitness tests: CMJ (effect size [ES]: 0.61 to 1.03), SLCMJ (ES: 0.60 to 2.25), linear speed (ES: −0.54 to −1.96), and COD speed (ES: −0.68 to −1.14). Significant reductions in asymmetry (ES: −0.68 to −1.07) and significant increases in the BLD (ES: 1.15 to 1.57) were also evident throughout the season. Additionally, kappa coefficients were used to determine consistency in limb dominance throughout the season, but only poor to fair levels of agreement (kappa: −0.17 to 0.37) were evident, highlighting the fluctuating nature of limb dominance throughout the season. Despite all tests exhibiting meaningful change, the SLCMJ and linear speed showed the most frequent and largest differences in performance, highlighting their usefulness in the ongoing monitoring process of physical capacities in elite male academy players across a competitive soccer season.
Five‐year mortality of heart failure with preserved, mildly reduced, and reduced ejection fraction in a 4880 Chinese cohort

Available evidence is incomplete and inconsistent in the outcomes of heart failure (HF) patients with preserved ejection fraction (HFpEF), mildly reduced ejection fraction (HFmrEF), and reduced ejection fraction (HFrEF). There are also limited data on the proportions and long‐term prognosis among the three HF phenotypes in China. We aimed to characterize the 5 year prognosis in three HF phenotypes according to EF in a cohort of hospitalized HF patients undergoing coronary angiography in southern China.
Adaptive Event-Triggered Time-Varying Output Bipartite Formation Containment of Multiagent Systems Under Directed Graphs

The time-varying output bipartite formation containment (TVOBFC) problem for linear multiagent systems (MASs) under directed graphs is an important problem. However, the methods in existing works rely on the global information of the MASs or do not use event-triggered communication. This article investigates two kinds of TVOBFC problems for heterogeneous linear MASs under signed digraphs by event-triggered communication. For the first case where leaders have the same dynamics, the innovative fully distributed event-triggered protocol for the follower is proposed. In this case, the followers form the preset formation shape. For the second case where leaders have different dynamics, the leaders are divided into two groups. One group can directly obtain the output information of the virtual leader, while the other group cannot. In order to make leaders achieve the formation shape and track the virtual leader, two kinds of innovative observers are designed for two kinds of leaders to estimate the state of the virtual leader, and the control protocol is designed for each leader based on the designed observers. Then, the control law for each follower is designed to solve the formation containment problem. Finally, two examples are introduced to illustrate the main results.
Left ventricular reverse remodelling and its predictors in non‐ischaemic cardiomyopathy

Adverse remodelling following an initial insult is the hallmark of heart failure (HF) development and progression. It is manifested as changes in size, shape, and function of the myocardium. While cardiac remodelling may be compensatory in the short term, further neurohumoral activation and haemodynamic overload drive this deleterious process that is associated with impaired prognosis. However, in some patients, the changes may be reversed. Left ventricular reverse remodelling (LVRR) is characterized as a decrease in chamber volume and normalization of shape associated with improvement in both systolic and diastolic function. LVRR might occur spontaneously or more often in response to therapeutic interventions that either remove the initial stressor or alleviate some of the mechanisms that contribute to further deterioration of the failing heart. Although the process of LVRR in patients with new‐onset HF may take up to 2 years after initiating treatment, there is a significant portion of patients who do not improve despite optimal therapy, which has serious clinical implications when considering treatment escalation towards more aggressive options. On the contrary, in patients that achieve delayed improvement in cardiac function and architecture, waiting might avoid untimely implantable cardioverter‐defibrillator implantation. Therefore, prognostication of successful LVRR based on clinical, imaging, and biomarker predictors is of utmost importance. LVRR has a positive impact on prognosis. However, reverse remodelled hearts continue to have abnormal features. In fact, most of the molecular, cellular, interstitial, and genome expression abnormalities remain and a susceptibility to dysfunction redevelopment under biomechanical stress persists in most patients. Hence, a distinction should be made between reverse remodelling and true myocardial recovery. In this comprehensive review, current evidence on LVRR, its predictors, and implications on prognostication, with a specific focus on HF patients with non‐ischaemic cardiomyopathy, as well as on novel drugs, is presented.