Miracle-dz/UniFAR-FTUs huggingface dataset:
DMSO_A_342936 1911..1923

The health and economic burden of diabetes mellitus across the United States and the world is such that effective care is crucial to improving outcomes, including macro and microvascular complications, and lowering health care costs. Pharmacists are well placed within communities to provide the critical care necessary for patients with diabetes and have a unique skillset that has demonstrated clear benefits in clinical and non-clinical outcomes. Here, we will provide a narrative review of the literature including the role of the pharmacist in different care models, outcomes associated with pharmacist care, and future directions and opportunities for pharmacist-managed diabetes.
On the Convergence to a Global Solution of Shuffling-Type Gradient Algorithms

Stochastic gradient descent (SGD) algorithm is the method of choice in many machine learning tasks thanks to its scalability and efficiency in dealing with large-scale problems. In this paper, we focus on the shuffling version of SGD which matches the mainstream practical heuristics. We show the convergence to a global solution of shuffling SGD for a class of non-convex functions under over-parameterized settings. Our analysis employs more relaxed non-convex assumptions than previous literature. Nevertheless, we maintain the desired computational complexity as shuffling SGD has achieved in the general convex setting.
Benefits of Expressive Arts in Coping with Anxiety for Inpatient Adolescents: Development of a Method

Developmentally, adolescence is a period of change and for teens experiencing psychiatric crisis, these changes may be more difficult to manage. Adolescents admitted to a psychiatric inpatient unit are often experiencing emotional or psychological crises and complex mental health needs. The arts-based intervention that took place aimed to seek the benefits of artmaking in coping with anxiety and stress for adolescents in a short-term psychiatric inpatient unit who all experience symptoms of anxiety. Patients, ages 12-18, participated in three expressive arts groups that used watercolor to encourage the use of arts-based interventions to cope with anxiety, encourage connections with peers to build a sense of belonging, and increase a sense of self. The results demonstrated an increase in presence, focus, and relaxation while using watercolors. Altogether, this paper emphasized the benefits of arts-based interventions, specifically watercolor, and the need for more arts-based interventions during treatment for the inpatient setting.
CMAR_A_358939 2031..2040

1Department of Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong-si, Gyeonggi, 445-170, Republic of Korea; 2Department of Surgery, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, 445-907, Republic of Korea; 3Department of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, 150-950, Republic of Korea; 4Department of Surgery, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, 134-701, Republic of Korea
Performance-Aware Mutual Knowledge Distillation for Improving Neural Architecture Search

Knowledge distillation has shown great effectiveness for improving neural architecture search (NAS). Mutual knowledge distillation (MKD), where a group of models mutually generate knowledge to train each other, has achieved promising results in many applications. In existing MKD methods, mutual knowledge distillation is performed between models without scrutiny: a worse-performing model is allowed to generate knowledge to train a better-performing model, which may lead to collective failures. To address this problem, we propose a performance-aware MKD (PAMKD) approach for NAS, where knowledge generated by model $A$ is allowed to train model $B$ only if the performance of $A$ is better than B. We propose a three-level optimization framework to formulate PAMKD, where three learning stages are performed end-to-end: 1) each model trains an initial model independently; 2) the initial models are evaluated on a validation set and better-performing models generate knowledge to train worse-performing models; 3) architectures are updated by minimizing a validation loss. Experimental results on a variety of datasets demonstrate that our method is effective.
Bibliotherapy with Children with Neurodiverse Profiles: A Literature Review

Expressive arts therapy interventions are continuing to gain recognition as a means of healing for individuals with a wide range of diagnoses. Bibliotherapy is a particularly under researched modality of the expressive arts, leaving ample opportunity for future research on both reading and writing interventions. While bibliotherapy may not be a widespread subject of study, preliminary research shows that reading and writing therapies can promote emotional well-being for individuals dealing with mental illness. Children with neurodiverse profiles (NP) are more likely to be diagnosed with psychiatric disorders such as depression, anxiety, bipolar disorder, and schizophrenia, than neurotypical children. Although previous research has suggested that bibliotherapy is an effective form of treatment for individuals with these diagnoses, the impact of reading and writing therapies on children with NP is significantly understudied. Given the correlation between NP and mental illness, the positive effects of bibliotherapy for individuals with mental illness could possibly translate to children with NP. However, it is crucial to consider the individual needs and learning styles of individuals with NP, such as their struggles and limitations in reading, writing, language, and processing. This literature review examines relevant research on three topics: the relationship between NP and mental illness, bibliotherapy as treatment for mental illness, and limitations and considerations of reading and writing for children with NP, in order to further understand how bibliotherapy could be used with children with NP.
Depression, Posttraumatic Stress Disorder, and Functional Disability in Survivors of Critical Illness: results from the BRAIN ICU (Bringing to light the Risk Factors And Incidence of Neuropsychological dysfunction in ICU survivors) Investigation: A Longitudinal Cohort Study

Background—Critical illness is associated with cognitive impairment, but mental health and functional disabilities in general intensive care unit (ICU) survivors are inadequately characterized and there are a paucity of data regarding the relationship between age and delirium and these outcomes. Methods—In this prospective, multisite cohort study, we enrolled medical/surgical ICU patients with respiratory failure or shock, collected detailed demographics and in-hospital variables, and assessed survivors at 3 and 12 months with measures of depression, posttraumatic stress disorder (PTSD) and functional disability. We used linear and proportional odds logistic regression to examine the independent associations between age and delirium duration versus mental health and functional disabilities. Findings—We enrolled 821 patients with a median (interquartile range) age of 61 (51, 71), assessing 448 patients and 382 patients 3 and 12 months after discharge. At 3and 12-month follow-up, 37% (149/407) and 33% (116/347) of subjects reported at least mild depression, driven primarily by somatic rather than cognitive symptoms. Depressive symptoms were common even among those with no proxy reported history of depression, reported at 3and 12-month follow-up by 30% (76/255) and 29% (62/217) of these individuals. At either follow-up assessment, only 7% (27/415, 24/361) of subjects had symptoms consistent with PTSD. Disabilities in basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs) were present in 32% (139/428) and 26% (108/422) of individuals at 3 months and in 27% (102/374) and 23%(87/372) at 12 months. Mental health and functional difficulties were prevalent in young and old patients. Although older age was frequently associated with mental health and functional disabilities, no consistent association was observed between delirium and these outcomes. Interpretation—In contrast with early single-center reports, data from this large, multicenter investigation reveal depression is much more common than PTSD after critical illness and is driven by somatic symptoms indicative of physical disabilities rather than by cognitive symptoms. Poor mental health and functional disability were common, and persistent in up to a quarter of patients.
Absorption Band Substructure and Exciton Dynamics

Spectral substructure and ultrafast excitation dynamics have been investigated in the chlorophyll (Chi) a and b QY region of isolated plant light-harvesting complex 11 (LHC 11). We demonstrate the feasibility of Nonlinear Polarization Spectroscopy in the frequency domain, a novel photosynthesis research laser spectroscopic technique, to determine not only ultrafast population relaxation (T1) and dephasing (T2) times, but also to reveal the complex spectral substructure in the Qy band as well as the mode(s) of absorption band broadening at room temperature (RT). The study gives further direct evidence for the existence of up to now hypothetical "Chl forms". Of particular interest is the differentiated participation of the Chl forms in energy transfer in trimeric and aggregated LHC II. Limits for T2 are given in the range of a few ten fs. Inhomogeneous broadening does not exceed the homogeneous widths of the subbands at RT. The implications of the results for the energy transfer mechanisms in the antenna are discussed.
789-Wells and McGee.indd

789 ABSTRACT. Objective: For 3 decades, studies have reported that the usual sequence of drug initiation is licit drugs, then cannabis, and then other illicit drugs. This article describes the prevalence of violations of this sequence, the predictors of violations, and the relationship between violations and the onset of alcohol or drug dependence. Method: The New Zealand Mental Health Survey is a nationally representative sample with 12,992 face-to-face interviews carried out in 2003-2004. The response rate was 73.3%. The World Health Organization Composite International Diagnostic Interview (CIDI 3.0) was used in the survey. Reports of the age at fi rst use were obtained for alcohol and drugs but not for smoking. Results: Violations of the usual sequence of drug initiation were uncommon in the population (2.6%). Use of other illicit drugs before cannabis was the main violation, found in 2.3% of alcohol users, 3.0% of cannabis users, 8.6% of cocaine users, and 16.7% of those who had used other illicit drugs. Use of other illicit drugs before cannabis was more predominant in younger cohorts and those with more early-onset internalizing disorders. Violations had little association with the development of dependence in users when other important predictors such as age at onset of use and the number of illicit drugs used were taken into account. Internalizing disorders and early-onset bipolar disorder also predicted dependence. Conclusions: In New Zealand, violations of the gateway sequence are not common and they are not markers of progression to dependence. (J. Stud Alcohol Drugs 69: 789-795, 2008)
Revision surgery following Total Shoulder Arthroplasty: Analysis of 2,588 shoulders over 3 decades (1976–2008)

Jasvinder A. Singh, MBBS, MPH1,2,3, John W. Sperling, MD3, and Robert H. Cofield, MD3 1Medicine Service and Center for Surgical Medical Acute Care Research and Transitions (CSMART), Birmingham VA Medical Center, Birmingham, AL 2Department of Medicine, University of Alabama, and Division of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 3Department of Orthopedic Surgery, Mayo Clinic School of Medicine, Rochester, MN 4Department of Health Sciences Research, Mayo Clinic School of Medicine, Rochester, MN
An X-Ray Diffraction Study on Mouse Cardiac Cross-Bridge Function In Vivo: Effects of Adrenergic b -Stimulation

To investigate how b -stimulation affects the contractility of cardiac muscle, x-ray diffraction from cardiac muscle in the left ventricular free wall of a mouse heart was recorded in vivo. To our knowledge, this is the ﬁrst x-ray diffraction study on a heart in a living body. After the R wave in electrocardiograms, the ratio of the intensities of the equatorial (1,0) and (1,1) reﬂections decreased for ; 50 ms from a diastolic value of 2.1 to a minimum of 0.8, and then recovered. The spacing of the (1,0) lattice planes increased for ; 90 ms from a diastolic value of 37.2 nm to a maximum of 39.1 nm, and then returned to the diastolic level, corresponding to ; 10% stretch of sarcomere. Stimulation of b -adrenergic receptor by dobutamine (20 m g/kg/ min) accelerated both the decrease in the intensity ratio, which reached a smaller systolic value, and the increase in the lattice spacing. However, the intensity ratio and spacing at the end-diastole were unchanged. The recovery of the lattice spacing during relaxation was also accelerated. The mass transfer to the thin ﬁlaments at systole in a b -stimulated heart was close to the peak value in twitch of frog skeletal muscle at 4 (cid:1) C, showing that the majority of cross-bridges have been recruited with few in reserve. The ‘‘apparent’’ thin-ﬁlament mass thus calculated was interpreted as consisting of the thin ﬁlament and the myosin heads present in the vicinity of the thin ﬁlament. The mass of the thin ﬁlament was approximated by assuming that no myosin heads are present in the vicinity of the thin ﬁlament at the resting state. Then, by subtracting this from the apparent thin-ﬁlament mass, the mass of heads associated with the thin ﬁlament was obtained. The same procedure was done with the intensity ratio obtained in the rigor state, and the total mass of heads can be obtained by assuming that all heads are attached to the thin ﬁlament. From these masses of heads, the proportion of heads present in the vicinity of thin ﬁlaments was calculated. All data are expressed as mean 6 SD. Differences were analyzed us- ing Student’s paired t -test with p , 0.05 being regarded as statistically signiﬁcant.
The Survival Time of DF32P-labelled Erythrocytes

The study indicated that intravenously administered DF32P was a suitable label for mink erythrocytes. The mean survival time of erythrocytes of 29 adult male mink labelled with diisopropyl phosphorofluoridate32P(DF32P) was 92.2 + 4.1 (SEM) days. Three colour types were tested: standard dark, pastel and sapphire. No significant difference in erythrocyte life span relating to colour type was apparent in these animals.
The human and mouse enteric nervous system at single cellresolution

Eugene Drokhlyansky#1, Christopher S. Smillie#1, Nicholas Van Wittenberghe#1, Maria Ericsson2, Gabriel K. Griffin3,4, Gokcen Eraslan1, Danielle Dionne1, Michael S. Cuoco1, Max N. Goder-Reiser5, Tatyana Sharova5, Olena Kuksenko1, Andrew J. Aguirre3,6, Genevieve M. Boland7, Daniel Graham3,7,8, Orit Rozenblatt-Rosen1,*, Ramnik J. Xavier3,7,8,9,*, Aviv Regev1,10,11,*,** 1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Research of risk assessment and prediction based on support vector machine

Building a suitable credit risk evaluation model is very important, that is because loan business is one of the most important assets of commercial Banks. In this paper, we introduce a kind of learning algorithm which contains small sample learning and construct a new method which is called support vector machine (SVM). SVM is developed based on a new theory that is popular used in the field of intelligent learning system in recent years. The credit risk assessment model of commercial bank is established finally. By multiple discriminate analyses and the comparison of neural network model, confirms the validity and superiority of the method when be used in risk assessment.
Translation of g-Globin m-RNA in 3-Thalassemia and the S and C Hemoglobinopathies

A B S T R A C T Genetic and biochemical evidence indicates that in 13-thalassemia there is impaired synthesis of the P-globin chains of hemoglobin A. In patients heterozygous for the hemoglobinopathies, hemoglobin S and hemoglobin C, the mutant 1-chain is produced in smaller amounts than normal PI. Defective m-RNA translation has been suggested as a possible cause of decreased 1-globin polypeptide synthesis in thalassemia and the hemoglobinopathies. In the present study, the ribosomal assembly of 13-globin chains was examined in the peripheral, nucleated red blood cells and reticulo-cytes of patients with Cooley's anemia, thalassemia in-termedia, sickle thalassemia, sickle cell anemia, hemoglobin C disease, and in hemolytic anemias not associated with a hemoglobinopathy. The translation times of PA Ps , and P' did not differ significantly (average times: pA = 75 sec. range 43-114, ps = 69 sec, pc = 92 sec). In thalassemia, no evidence was found for a delay in translation as the cause of the marked impairment of 13-globin synthesis. In several specimens of peripheral blood from thalassemic patients, the translation time of the P-chain was even shorter than in nonthalassemic specimens (average time = 45 sec, range 35-59). The results suggest that the defect in 13-globin synthesis in P-thalassemia is due to impaired initiation of 13-globin chain assembly or a quantitative deficiency in m-RNA.
Physics of brain dynamics: Fokker-Planck analysis reveals changes in EEG δ and θ activity during anæsthesia

We use drift and diffusion coefficients to reveal interactions between different oscillatory processes underlying a complex signal and apply the method to EEG δ and θ frequencies in the brain. By analysis of data recorded from rats during anæsthesia we consider the stability and basins of attraction of fixed points in the phase portrait of the deterministic part of the retrieved stochastic process. We show that different classes of dynamics are associated with deep and light anæsthesia, and we demonstrate that the predominant directionality of the interaction is such that θ drives δ.
A New Aspect of Ethanol Metabolism: Isolation of Ethyl-glucuronide.

trials, extending over 8 months, in which a total of over 250 guinea pigs have beern tested; and it is of a very high order of statistical significance. The application of these findings to the con-struction of dose-response curves, comparing the effects of cortisone and ACTH fractions in quanti-tative biological assays, on guinea pigs and other species, will be discussed.
The peroxidase activity of mitochondrial superoxide dismutase (MnSOD/SOD2)

Manganese superoxide dismutase (MnSOD) is an integral mitochondrial protein known as a first line antioxidant defense against superoxide radical anions produced as by-products of the electron transport chain. Recent studies have shaped the idea that by regulating the mitochondrial redox status and H2O2 outflow, MnSOD acts as a fundamental regulator of cellular proliferation, metabolism and apoptosis thereby assuming roles that extend far beyond its proposed antioxidant functions. Accordingly, allelic variations of MnSOD that have been shown to augment levels of MnSOD in mitochondria result in a 10-fold increase in prostate cancer risk. In addition, epidemiologic studies indicate that reduced glutathione peroxidase (GPx) activity along with increases in H2O2 further increase cancer risk in the face MnSOD overexpression. These facts led us to hypothesize that, like the Cu, Zn-counterpart, MnSOD may work as a peroxidase, utilizing H2O2 to promote mitochondrial damage, a known cancer risk factor. Here we report that MnSOD indeed possesses peroxidase activity that manifests in mitochondria when the enzyme is overexpressed.
Calcium binding by phosphatidylserine headgroups

The binding of calcium to headgroup deuterated 1 -palmitoyl, 2-oleoyl-sn-glycero-3-phosphoserine (POPS) was investigated by using deuterium magnetic resonance in pure POPS membranes and in mixed 1 -palmitoyl, 2-oleoyl-sn-glycero-3phosphocholine (POPC)/POPS 5:1 (m:m) bilayers. Addition of CaCI2 to pure POPS bilayers led to two component spectra attributed, respectively, to liquid-crystalline POPS (<15 kHz) and POPS molecules in the calcium-induced dehydrated phase (cochleate) (= 120 kHz). The liquid-crystalline component has nearly disappeared at a Ca2+ to POPS ratio of 0.5, indicating that, under such conditions, most of the POPS molecules are in the precipitated cochleate phase. After dilution of the POPS molecules in zwitterionic POPC membranes (POPC/POPS 5:1 m:m), single component spectra characteristic of POPS in the liquid-crystalline state were observed in the presence of Molar concentrations of calcium ions (Ca2+ to POPS ratio > 50), showing that the amount of dehydrated cochleate PS-Ca2+ phase, if any, was low (< 5%) under such conditions. Deuterium NMR data obtained in the 1 5-50°C temperature range with the mixed PC/PS membranes, either in the absence or the presence of Ca2+ ions, indicate that the serine headgroup undergoes a temperature-induced conformational change, independent of the presence of Ca2+. This is discussed in relation to other headgroup perturbations such as that observed upon change of the membrane surface charge density.
DISCOVERY EXPRESS In Situ Forming Nutritional and Temperature Sensitive Scaffold Improves the Esthetic Outcomes of Meshed Split-Thickness Skin Grafts in a Porcine Model

Amir Pourghadiri, Hatem Alnojeidi, Reza Jalili, Ruhangiz T. Kilani, Layla Nabai, and Aziz Ghahary* BC Professional Firefighters’ Burn and Wound Healing Research Laboratory, Department of Surgery, Division of Plastic Surgery, University of British Columbia (UBC), Vancouver, British Columbia, Canada. International Collaboration on Repair Discoveries (ICORD), University of British Columbia (UBC), Vancouver, British Columbia, Canada.