Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis

The triggering receptors expressed on myeloid cells (TREMs) are a family of activating immune receptors that regulate the inflammatory response. TREM-1, which is expressed on monocytes and/or macrophages and neutrophils, functions as an inflammation amplifier and plays a role in the pathogenesis of rheumatoid arthritis (RA). Unlike TREM-1, the role in RA of TREM-2, which is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, remains unclear and controversial. TREM-2 ligands are still unknown, adding further uncertainty to our understanding of TREM-2 function. Previously, we demonstrated that TREM-1 blockade, using a ligand-independent TREM-1 inhibitory peptide sequence GF9 rationally designed by our signaling chain homooligomerization (SCHOOL) model of cell signaling, ameliorates collagen-induced arthritis (CIA) severity in mice. Here, we designed a TREM-2 inhibitory peptide sequence IA9 and tested it in the therapeutic CIA model, either as a free 9-mer peptide IA9, or as a part of a 31-mer peptide IA31 incorporated into lipopeptide complexes (IA31-LPC), for targeted delivery. We demonstrated that administration of IA9, but not a control peptide, after induction of arthritis diminished release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage, suggesting that targeting TREM-2 may be a promising approach for the treatment of RA.
Understanding the Role of Psychosocial Factors in Pakistani Parents’ Hesitancy to Vaccinate Their Kids: The Mediating Role of Knowledge and Mistrust of Science about the COVID-19 Vaccine

Vaccination is a vital component in the battle against outbreaks of infectious diseases. Recognizing parents’ reluctance to vaccinate their children is even more critical now, given the ongoing threat of a COVID-19 pandemic. Conspiracy theories, vaccination safety concerns, parental efficacy and risk perception, and a lack of confidence in science all influence intention. To investigate how these variables interact with vaccination behavior against COVID-19, we developed a model with psychosocial factors serving as the predictor and mistrust in science and vaccine knowledge serving as the mediator. In order to validate the model, the parents’ intentions regarding their children’s vaccination with COVID-19 were used. The study included 454 Pakistani parents who completed an online questionnaire assessing their intention to vaccinate their children. We analyzed the data using structural equation modeling (SEM). A significant level of vaccine hesitation is due to belief in vaccine conspiracy theories, and vaccine safety concerns were investigated. A surprising correlation exists between risk perception and vaccination intentions, followed by parental self-efficacy. It is significant to note that vaccine knowledge mediated conspiracy beliefs, risk perceptions, and intentions fully but partially mediated parental self-efficacy. Conspiracy theories were mediated by a mistrust in science, while perceptions of risk and vaccine safety were partially mediated. The findings of this research were used to develop sensible policy reforms and public health campaigns to encourage vaccination against both common infections such as measles, human papillomaviruses, or pertussis, and novel diseases such as COVID-19.
The Effectiveness of the Balance Scorecard as a Tool to Measure Organizational Performance: A Case Study of CIC Group

iv ACKNOWLEDGEMENT . vi DEDICATION. vii LIST OF TABLES . xi LIST OF FIGURES . xii ACRONYMS AND ABBREVIATIONS . xiii CHAPTER ONE . 1 1.0 INTRODUCTION . 1 1.1 Background of the Problem . 1 1.2 Statement of the Problem . 3 1.3 Purpose of the Study . 4 1.4 Research Questions . 5 1.5 Significance of the Study . 5 1.6 Scope of the Study . 5 1.7 Definition of Terms.6 1.8 Chapter Summary . 7 2.0 LITERATURE REVIEW . 8 2.
Detailed EMT-Type Load Modeling for Power System Dynamic and Harmonic Studies

The aim of this paper is to develop a detailed model and investigate its importance for capturing load behavior in both dynamic and harmonic simulations. A detailed electromagnetic transient (EMT) type model of a mixed residential-commercial load is developed using a component-based technique, and its dynamic characteristic is validated against existing field measurements. The model is subsequently used to study the harmonic impedance of an existing underground distribution network. Errors caused by model inadequacies are also studied in both dynamic and harmonic case studies.
Parental Knowledge of Appendicitis and Preference for Operative or Non-Operative Treatment at a United Kingdom Children’s Hospital

Appendicitis is a common cause of abdominal pain in children, and is the most common reason for children to undergo emergency abdominal surgery. To guide our research program in this field, we aimed to determine parental understanding with regard to appendicitis and its treatment. We also wished to assess parental preference for non-operative or surgical treatment of children with uncomplicated appendicitis. We asked parents attending a children’s outpatient clinic to complete a brief questionnaire that was interspersed with educational content to rectify any knowledge gaps. A total of 396 parents (of 414 approached) agreed to participate. There were gaps in parental knowledge, including not knowing where the appendix is located (one-third of respondents), not knowing what appendicitis is (40% of respondents), and underestimating the incidence of appendicitis. Parents typically overestimated the risks of complications and dying from both uncomplicated and complicated appendicitis. There was no influence of gender, age, or previous experience of appendicitis on these findings. When presented with the scenario of equal effectiveness of non-operative treatment and surgery for uncomplicated appendicitis, 59% of respondents expressed a preference for non-operative treatment over surgery, while 21% expressed a preference for surgery (20% expressed no preference). These findings are important for clinicians and researchers when discussing appendicitis and treatment options with families, and justify ongoing research into the comparative effectiveness of non-operative treatment and surgery.
The Impact of the Oil Phase Selection on Physicochemical Properties, Long-Term Stability, In Vitro Performance and Injectability of Curcumin-Loaded PEGylated Nanoemulsions

A nanotechnology-based approach to drug delivery presents one of the biggest trends in biomedical science that can provide increased active concentration, bioavailability, and safety compared to conventional drug-delivery systems. Nanoemulsions stand out amongst other nanocarriers for being biodegradable, biocompatible, and relatively easy to manufacture. For improved drug-delivery properties, longer circulation for the nanoemulsion droplets should be provided, to allow the active to reach the target site. One of the strategies used for this purpose is PEGylation. The aim of this research was assessing the impact of the oil phase selection, soybean or fish oil mixtures with medium chain triglycerides, on the physicochemical characteristics and injectability of curcumin-loaded PEGylated nanoemulsions. Electron paramagnetic resonance spectroscopy demonstrated the structural impact of the oil phase on the stabilizing layer of nanoemulsions, with a more pronounced stabilizing effect of curcumin observed in the fish oil nanoemulsion compared to the soybean oil one. The design of the experiment study, employed to simultaneously assess the impact of the oil phase, different PEGylated phospholipids and their concentrations, as well as the presence of curcumin, showed that not only the investigated factors alone, but also their interactions, had a significant influence on the critical quality attributes of the PEGylated nanoemulsions. Detailed physicochemical characterization of the NEs found all formulations were appropriate for parenteral administration and remained stable during two years of storage, with the preserved antioxidant activity demonstrated by DPPH and FRAP assays. In vitro release studies showed a more pronounced release of curcumin from the fish oil NEs compared to that from the soybean oil ones. The innovative in vitro injectability assessment, designed to mimic intravenous application, proved that all formulations tested in selected experimental setting could be employed in prospective in vivo studies. Overall, the current study shows the importance of oil phase selection when formulating PEGylated nanoemulsions.
Chip-Based Brillouin Processing for Microwave Photonic Phased Array Antennas

In this review paper, we provide perspectives on the implementation of high-performance, wideband, chip-based Brillouin microwave photonic processing subsystems for use in phased array antennas that require processing at every antenna element. We review recent advances in chip-scale Brillouin microwave photonic signal processing systems, including reconfigurable filters, frequency converters, tunable phase shifters, true time delays and microwave sources, which are key functionalities for phased array antennas. We discuss a roadmap for developments of Brillouin-based microwave photonic processors to reach the required performance and compact footprint for implementation in future dynamically reconfigurable phased array antenna systems.
Spousal Violence and Contraceptive Use among Married Afghan Women in a Nationally Representative Sample

Objective: Afghanistan is one of the countries with the highest prevalence of spousal violence (56%) and a low prevalence of contraceptive use (23%), yet there is no study assessing how spousal violence is related to contraceptive use, and what methods are most used by women. Therefore, this study examined the association between the number of types of spousal violence and contraceptive use. Method: Using data from 18,985 Afghan married women, aged 15 to 49, who responded to the 2015 Afghanistan Demographic and Health Survey, the current contraceptive method was grouped into five categories: male-involved methods, pills, injectables, long-acting reversible contraception, female sterilization, and Lactation Amenorrhea Method. The number of types of spousal violence in the past 12 months was categorized as none, one type, or two or more types, based on women’s experiences with verbal, physical, and sexual violence. For analysis, binary and multinomial logistic regression were used. Results: After adjusting for the covariates, the experience of any spousal violence was associated with contraception use (adjusted odds ratio (aOR) = 1.93, 95% CI: 1.64–2.27, p = 0.0001). Among those using contraception, experiencing two or three types of spousal violence was associated with using pills (adjusted risk ratio (aRRR) = 2.12, 95% CI: 1.63–2.77, p = 0.0001), injections (aRRR = 1.75, 95% CI: 1.26–2.41, p = 0.001), and LAM (aRRR = 3.27, 95% CI: 2.05–5.20, p = 0.0001), compared to male-involved methods. Conclusions: The findings of this study may inform policymakers and program implementers in designing interventions to address the pervasive problem of violence against women, and make pills and injectables more accessible to Afghan women, since these methods are under women’s control and more often used in Afghanistan.
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection

Coagulation factor Xa (fXa) and thrombin (thr) are widely expressed in pulmonary tissues, where they may catalyze, together with the transmembrane serine protease 2 (TMPRSS2), the coronaviruses spike protein (SP) cleavage and activation, thus enhancing the SP binding to ACE2 and cell infection. In this study, we evaluate in vitro the ability of approved (i.e., dabigatran and rivaroxaban) and newly synthesized isonipecotamide-based reversible inhibitors of fXa/thr (cmpds 1–3) to hinder the SARS-CoV-2 infectivity of VERO cells. Nafamostat, which is a guanidine/amidine antithrombin and antiplasmin agent, disclosed as a covalent inhibitor of TMPRSS2, was also evaluated. While dabigatran and rivaroxaban at 100 μM concentration did not show any effect on SARS-CoV-2 infection, the virus preincubation with new guanidino-containing fXa-selective inhibitors 1 and 3 did decrease viral infectivity of VERO cells at subtoxic doses. When the cells were pre-incubated with 3, a reversible nanomolar inhibitor of fXa (Ki = 15 nM) showing the best in silico docking score toward TMPRSS2 (pdb 7MEQ), the SARS-CoV-2 infectivity was completely inhibited at 100 μM (p < 0.0001), where the cytopathic effect was just about 10%. The inhibitory effects of 3 on SARS-CoV-2 infection was evident (ca. 30%) at lower concentrations (3–50 μM). The covalent TMPRSS2 and the selective inhibitor nafamostat mesylate, although showing some effect (15–20% inhibition), did not achieve statistically significant activity against SARS-CoV-2 infection in the whole range of test concentrations (3–100 μM). These findings suggest that direct inhibitors of the main serine proteases of the blood coagulation cascade may have potential in SARS-CoV-2 drug discovery. Furthermore, they prove that basic amidino-containing fXa inhibitors with a higher docking score towards TMPRSS2 may be considered hits for optimizing novel small molecules protecting guest cells from SARS-CoV-2 infection.
DNA Barcoding of Stingless Bees (Hymenoptera: Meliponini) in Northern Peruvian Forests: A Plea for Integrative Taxonomy

Stingless bees (Hymenoptera: Meliponini) are among the most important pollinators of tropical forests. Peru is considered a hotspot of biodiversity of Meliponini, but many areas of this country (e.g., Peruvian Amazon) remain unexplored. We aimed to produce a first inventory of stingless bee species dwelling in humid and seasonally dry forests of northern Peru by combining traditional (morphologically-based) taxonomy and DNA barcoding. Specimens were collected in 2020 at five sites located in San Martin and Piura regions. We identified 12 genera of Meliponini. Among those, Trigona and Plebeia were the most abundant (45.9% and 12.8% respectively), whereas Nannotrigona and Scaura were the least represented ones (2.3%). We assigned a reliable species identification to about 30% of specimens (Trigona amazonensis, T. muzoensis, T. williana, Partamona testacea, Scaura tenuis, Tetragona goettei, and Tetragonisca angustula). Yet, more than a half of the specimens received a provisional identification (e.g., Geotrigona cf. fulvohirta, T. cf. amalthea, T. cf. fuscipennis, T. cf. hypogea, Melipona cf. cramptoni, Partamona cf. epiphytophila, Ptilotrigona cf. perenae, Scaura cf. latitarsis, Tetragona cf. clavipes, Trigonisca cf. atomaria). We also highlighted an extensive polyphyly that affected a number of currently recognized species (e.g., T. fulviventris, T. guianae, Plebeia franki, P. frontalis, M. eburnea, M. illota), whose members were split into various clades. Finally, 16% of individuals failed to be identified at the species level (Trigona sp. 1, T. sp. 2, Nannotrigona sp., Partamona sp., Scaptotrigona sp. 1, S. sp. 2, Trigonisca sp. 1, and Trigonisca sp. 2). We discuss our findings according to the current faunistic and biogeographic knowledge of Meliponini in Peru and the Neotropical region. We also remark on the importance of conducting a taxonomic revision of stingless bees and improving both their morphology-based identification keys and BOLD repository. Finally, we claim that integrative taxonomy shall be strongly implemented to truly assess the biodiversity of Neotropical stingless bees, allowing conserving these important pollinators and the associated traditional meliponiculture in an effective manner.
ANTIOXIDANT PROPERTIES OF TOTAL LUTEIN CONTENT IN DIFFERENT PARTS OF PUMPKIN (Cucurbita maxima)

Pumpkin (Cucurbita maxima) is a vegetable crop which is commonly consumed as vegetables or incorporated into food products. Pumpkin flesh was reported abundant with carotenoid compounds includes α-carotene, β-carotene, β-cryptoxanthin, lutein and zeaxanthin. As this antioxidant related to the colour pigment, these nutrients highly potential to be in other parts of pumpkin such as peel and seed. Therefore, the aim of this was to determine the total lutein content in different parts of pumpkin and their antioxidant properties. The pumpkin would be collected and evaluated at the commercial maturity stage (60% to fully orange-yellow of fruit peel). The presence of the lutein properties using DPPH, FRAP and ABTS assays in different parts of pumpkin was tested by using microplate spectrophotometer and analysed statistically with SPSS version 20. Among of all pumpkin fruit parts, flesh presented the highest concentration of potential lutein extracts, followed by peel and seed, respectively. On the contrary, potential lutein extracts from the pumpkin peel had the highest antioxidant activity in terms of DPPH, FRAP and ABTS assays when compared to the lutein extracts in flesh and seeds. This study indicates that the potential lutein from Cucurbita maxima especially peel may be the alternative to be used as both natural antioxidants in food products due to increasing demand for natural food preservatives. Therefore, this study may act as a source for others to further study to optimize the usage of pumpkin by-products.
Emotional Quotient and Teaching Performance of Selected Faculty in a Higher Education Institution in the Philippines

Teachers are significant in shaping the minds of the youth and contributing to the quality of education. Thus, examining the relationship between Emotional Quotient (EQ), profile, and faculty performance is important. The 175 faculty of a Higher Education Institution (HEI) in the Philippines were randomly selected. Employing Jerabek's (1996) Emotional Intelligence Test, EQ was found, on average, to indicate the faculty’s ability to recognize and deal with their own and others’ emotions effectively. Analysis of variance, regression, and Pearson Correlation revealed a significant positive correlation between teaching performance and their EQ, confirming that emotional intelligence influences teaching performance. Further, the combined impact of education and academic rank influences EQ, which may be the basis for further study. It is recommended that EQ be considered by HEIs when hiring faculty. Intelligence and emotional quotient are equally important in generating high performance. Therefore, the study may contribute to the significance of faculty's EQ on productivity.
Psychological level of youth cadets in Bali

COVID-19 is a disease with very fast and deadly transmission, with the addition of sufferers who continue to increase every day. The impact of the spread of COVID-19 which continues to increase and is exacerbated by various policies issued by the government at the same time greatly affects various aspects including both socially, physically and psychologically. The purpose of the study was to determine psychological level of youth cadets in Bali. Design this research is a descriptive study research, the type of quantitative research. The sample of this study amounted to 245 respondents with purposive sampling technique. The measuring instrument uses a stress, anxiety and depression level questionnaire that is valid and reliable. Data were analyzed univariately using frequency distribution. The results showed that the psychological level of the Bali Poltrada Taruna students was in the normal category.
Use of a Practitioner-Friendly Behavior Model to Identify Factors Associated with COVID-19 Vaccination and Other Behaviors

The lack of capacity for the design and implementation of behavioral interventions in low-and-middle income countries (LMICs) has been recognized by the World Health Organization (WHO) and other global health institutions. There is a need to task-shift, to translate social and behavioral science concepts into “practitioner-friendly” models—models which can be used by intervention designers, implementers, and evaluators with limited technical and financial resources. We illustrate the use of the Fogg Behavior Model (FBM), a model identified as being easy for practitioners to adopt in low-resource settings. The study uses data across four different behaviors in Nigeria, Pakistan, and India. The behaviors examined are COVID-19 vaccine uptake, condom use, iron folate use, and modern contraceptive use. The data are from surveys of healthcare workers (HCWs), married men, women of reproductive age, and adolescents, respectively. The FBM states that behavior happens when both motivation and ability are present, and a prompt occurs. In other words, persons with high motivation and high ability are the first to adopt a behavior. We created a categorical variable for motivation and ability and tested whether high motivation and high ability are associated with a greater likelihood of adopting a behavior. In Nigeria, HCWs with high motivation and high ability had 27 times higher odds of being vaccinated. In Pakistan, married men with high motivation and high ability had 35 times higher odds of condom use with their wives. In India, women with high motivation and high ability had 9 times higher odds of iron folate use. In Nigeria, adolescents and young women with high motivation and high ability had 8 times higher odds of contraceptive use. The study findings suggest that the FBM has the potential to be applied in low resource settings for the design, implementation, and evaluation of behavioral interventions. Rigorous testing of the FBM using data from experimental or quasi-experimental studies is recommended.
A growth model for understanding female-owned enterprises

Numerous policy initiatives designed to support the growth of female-owned enterprises in the developing economies have repeatedly failed to achieve their objectives. Research recognizes the lack of contextualized growth models for defining female-owned enterprises in such contexts as the main issue. Thus, and drawing from our qualitative data, we propose a growth model to account for the business development activities of female-owned enterprises from a developing economy perspective. Through analyzing our qualitative data, it emerged that money (access and utilization), management (nonformal education and experience), and market (customer intelligence) were direct determinants of the growth trajectories of female-owned enterprises. Motherhood (household and family), meso-(membership of professional networks and social learning), and macro-environment (sociocultural and economic issues) indirectly influenced their growth by mediating women’s access and utilization of the aforementioned direct determinants. From that, we offer recommendations for practitioners including public authorities and key actors within the entrepreneurial ecosystem that provide the support infrastructure for female-owned enterprises in a developing economy.
Going technocratic? Diluting governing responsibility in electorally turbulent times

Abstract Technocracy has recently triggered growing scholarly interest, especially as an alternative form of ruling to both party government and populism. In the context of weakened parties-citizens links and increasing external constraints faced by Western European ruling parties, technocratic appointments might help deal with the responsibility-responsiveness dilemma highlighted by Peter Mair. However, research on the explanatory factors of technocratic appointments is still underdeveloped. This article argues that the recourse to technocracy is fuelled by electoral volatility. In contexts of high electoral turbulence – and even more when parties frequently enter or exit the party system – ruling parties turn to technocratic appointments to dilute responsibility. This expectation is tested through an original longitudinal multilevel dataset including 655 cabinets and 373 elections in 20 Western European countries from 1945 to 2021. The findings of this article contribute to the current debate on technocracy and shed new light on the general understanding behind political representation.