Miracle-dz/UniFAR-FTUs huggingface dataset:
/Cyclooxygenase-2 Pathway 2 Cells via a Cytosolic Phospholipase A Synthase in RAW 264.7 Macrophage-Like TLR3-Dependent Induction of Nitric Oxide

dsRNA is a by-product of viral replication capable of inducing an inﬂammatory response when recognized by phagocyte cells. In this study, we identify group IVA cytosolic phospholipase A 2 (cPLA 2 (cid:1) ) as an effector of the antiviral response. Treatment of RAW 264.7 murine macrophage-like cells with the dsRNA analog polyinosinic:polycytidylic acid (poly-IC) promotes the release of free arachidonic acid that is subsequently converted into PGE 2 by the de novo-synthesized cyclooxygenase-2 (COX-2) enzyme. These processes are blocked by the selective cPLA 2 (cid:1) inhibitor pyrrophenone, pointing out to cPLA 2 (cid:1) as the effector involved. In keeping with this obser-vation, the cPLA 2 (cid:1) phosphorylation state increases after cellular treatment with poly-IC. Inhibition of cPLA 2 (cid:1) expression and activity by either small interfering RNA (siRNA) or pyrrophenone leads to inhibition of the expression of the inducible NO synthase (iNOS) gene. Moreover, COX-2-derived PGE 2 production appears to participate in iNOS expression, because siRNA inhibition of COX-2 also leads to inhibition of iNOS, the latter of which is restored by exogenous addition of PGE 2 . Finally, cellular depletion of TLR3 by siRNA inhibits COX-2 expression, PGE 2 generation, and iNOS induction by poly-IC. Collectively, these ﬁndings suggest a model for macrophage activation in response to dsRNA, whereby engagement of TLR3 leads to cPLA 2 (cid:1) -mediated arachidonic acid mobilization and COX-2-mediated PGE 2 production, which cooperate to induce the expression of iNOS. The Journal of Immunology, 2007, 179: (cid:3) reference ampliﬁcation. quantitative real-time RT-PCR, cDNA was ampliﬁed by real-time PCR using the Absolute QPCR SYBR Green from ABgen and a Chromo4 De-tector PTI-200 (MJ Research). at 95°C 15 by 35 comprising each a denaturation step at 95°C for 30 s, an annealing step 60°C (iNOS) or 55°C (TLR3) s, exten- sion veriﬁed in all by analyzing the dissociation curves were obtained after PCR by increasing the to 90°C and reading every expression level for iNOS TLR3 respect calculated (cid:4)(cid:5)(cid:5)
Looking Further into the Future: Career Pathway Prediction

The problem of predicting one’s next career move (also known as job mobility prediction) is one of the most fundamental tasks in a computational job marketplace. The problem is helpful not only for recruiters to find potential talented labors but also for job seekers to understand and plan their future pathways. While there exist multiple studies to this problem, however, they mainly focus on how to predict the “immediate" next career move (i.e., one’s next company or job), thus lacking the information about one’s long-term career movement. To address this gap, we propose a unique task of predicting one’s future career pathway as a “sequence" (i.e., one’s next 𝑁 steps of career movement). Toward this challenge, we develop a new model, NAOMI , that uses: (1) multi-view graph embeddings and BERT embeddings from job titles and companies extracted from resumes, (2) job duration masking to adjust the job experience, and (3) neural collaborative reasoning to represent the multi-factors available among job seekers’ resume graph. Based on the multi-factor encoding, NAOMI predicts one’s next 𝑁 steps of job titles and companies. When evaluated with our large-scale real-world dataset with more than 300K job titles, NAOMI outperforms state-of-the-art baselines on predicting one’s career pathway of 𝑁 steps, more so as 𝑁 increases.
Growth Cycles in Argentina: The Recent Behavior Ciclos de crecimiento en Argentina: comportamiento reciente

“La propiedad intelectual de este artículo pertenece a la Comisión Económica para América Latina y el Caribe (CEPAL). La autorización para reproducir total o parcialmente este material debe solicitarse a la Comisión Económica para América Latina y el Caribe (CEPAL), División de Documentos y Publicaciones, publicaciones.cepal@un.org. Los Estados Miembros de las Naciones Unidas y sus instituciones gubernamentales pueden reproducir esta obra sin autorización previa. Solo se les solicita que mencionen la fuente e informen a la CEPAL de tal reproducción. ” Growth Cycles in Argentina’s: The Recent Behavior | Daniel E. Perrotti | Revista Económica La Plata, Vol. LXVII, Nro. 1 | Enero-Diciembre 2021 | ISSN 1852-1649 | https://doi.org/10.24215/18521649e23 | https://revistas.unlp. edu.ar/ economica | Facultad de Ciencias Económicas, Universidad Nacional de La Plata | La Plata | Buenos Aires | Argentina
Employees’ privacy perceptions: exploring the dimensionality and antecedents of personal data sensitivity and willingness to disclose

Abstract The processing of employees’ personal data is dramatically increasing, yet there is a lack of tools that allow employees to manage their privacy. In order to develop these tools, one needs to understand what sensitive personal data are and what factors influence employees’ willingness to disclose. Current privacy research, however, lacks such insights, as it has focused on other contexts in recent decades. To fill this research gap, we conducted a cross-sectional survey with 553 employees from Germany. Our survey provides multiple insights into the relationships between perceived data sensitivity and willingness to disclose in the employment context. Among other things, we show that the perceived sensitivity of certain types of data differs substantially from existing studies in other contexts. Moreover, currently used legal and contextual distinctions between different types of data do not accurately reflect the subtleties of employees’ perceptions. Instead, using 62 different data elements, we identified four groups of personal data that better reflect the multi-dimensionality of perceptions. However, previously found common disclosure antecedents in the context of online privacy do not seem to affect them. We further identified three groups of employees that differ in their perceived data sensitivity and willingness to disclose, but neither in their privacy beliefs nor in their demographics. Our findings thus provide employers, policy makers, and researchers with a better understanding of employees’ privacy perceptions and serve as a basis for future targeted research on specific types of personal data and employees.
Technology Transfer Through Patents: An Empirical Analysis

The purpose of this paper is to empirically analyze the determinants of the Spanish public universities to generate patents. The empirical study is based on data of 47 Spanish public universities. First, we use a factorial analysis, which allows us to differentiate between two main factors that could have an impact on the university patents. Then, we apply a binomial logistic regression model to estimate the determinants of the university patents, using these factors as independent variables. The results suggest that Universities with a high quality of research, a higher experience of their offices of technology transfer and a larger size tend to generate more patents.
Duration of Protection Against SARS-CoV-2 Reinfection and Associated Risk of Reinfection Assessed with Real-World Data

Importance: Better understanding of the protective duration of prior SARS-CoV-2 infection against reinfection is needed. Objective: Primary: To assess the durability of immunity to SARS-CoV-2 reinfection among initially unvaccinated individuals with previous SARS-CoV-2 infection. Secondary: Evaluate the crude SARS-CoV-2 reinfection rate and associated characteristics. Design and Setting: Retrospective observational study of HealthVerity data among 144,678,382 individuals, during the pandemic era through April 2021. Participants: Individuals studied had SARS-CoV-2 molecular diagnostic or antibody index test results from February 29 through December 9, 2020, with [≥]365 days of pre-index continuous closed medical enrollment, claims, or electronic health record activity. Main Outcome(s) and Measure(s): Rates of reinfection among index-positive individuals were compared to rates of infection among index-negative individuals. Factors associated with reinfection were evaluated using multivariable logistic regression. For both objectives, the outcome was a subsequent positive molecular diagnostic test result. Results: Among 22,786,982 individuals with index SARS-CoV-2 laboratory test data (2,023,341 index positive), the crude rate of reinfection during follow-up was significantly lower (9.89/1,000-person years) than that of primary infection (78.39/1,000 person years). Consistent with prior findings, the risk of reinfection among index-positive individuals was 87% lower than the risk of infection among index-negative individuals (hazard ratio, 0.13; 95% CI, 0.13, 0.13). The cumulative incidence of reinfection among index-positive individuals and infection among index-negative individuals was 0.85% (95% CI: 0.82%, 0.88%) and 6.2% (95% CI: 6.1%, 6.3%), respectively, over follow-up of 375 days. The duration of protection against reinfection was stable over the median 5 months and up to 1-year follow-up interval. Factors associated with an increased reinfection risk included older age, comorbid immunologic conditions, and living in congregate care settings; healthcare workers had a decreased reinfection risk. Conclusions and Relevance: This large US population-based study demonstrates that SARS-CoV-2 reinfection is uncommon among individuals with laboratory evidence of a previous infection. Protection from SARS-CoV-2 reinfection is stable up to one year. Reinfection risk was primarily associated with age 85+ years, comorbid immunologic conditions and living in congregate care settings; healthcare workers demonstrated a decreased reinfection risk. These findings suggest that infection induced immunity is durable for variants circulating prior to Delta.
Self-management of depression and anxiety amongst frail older adults in the United Kingdom: A qualitative study

Objectives: Depression and anxiety are common in frail older people and are associated with high levels of morbidity and mortality, yet they typically face greater barriers to accessing mental health treatments than younger people and express preferences for self-managing their symptoms. This study aims to explore frail older adults experiences of self-managing symptoms of depression and/or anxiety. Design: Qualitative semi-structured interviews, exploring experiences of depression and/or anxiety, ways participants self-managed these and the contexts within which this took place. Interviews were audio-recorded and transcribed verbatim. Participants: 28 frail older adults in the United Kingdom, purposively sampled for neighbourhood, frailty and symptoms of anxiety/depression. Analysis: Thematic analysis to inductively derive themes from the data. Results: Our findings suggest that frail older adults find maintaining routines, engaging in meaningful and creative activities and socialising important to self-manage depression and anxiety. These could all be adapted to the level of frailty experienced. Stoicism, acceptance, faith or addressing the perceived cause were helpful in some situations and for some personalities. Distraction and avoidance were helpful for more severe symptoms or where the causes of symptoms could not be resolved. Self-management strategies were less well-established for anxiety symptoms, especially when linked to newer health fears and worries about the future. Conclusions: Developing services and sources of information that support and facilitate key therapeutic components of self-management, which align with older adults preferred coping styles and take into account levels of frailty, may be a way of supporting frail older people waiting for mental health treatments or those who prefer not to access these. Greater awareness of anxiety and how it can be self-managed in frail older people is needed.
Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis

Background The complement system plays an important role in pathophysiology of cardiovascular disease (CVD), and might be involved in accelerated atherogenesis in rheumatoid arthritis (RA). The role of complement activation in response to treatment, and in development of premature CVD in RA, is limited. Therefore, we examined the effects of methotrexate (MTX) and tumor necrosis factor inhibitors (TNFi) on complement activation using soluble terminal complement complex (TCC) levels in RA; and assessed associations between TCC and inflammatory and cardiovascular biomarkers. Methods We assessed 64 RA patients starting with MTX monotherapy (n = 34) or TNFi with or without MTX co-medication (TNFi±MTX, n = 30). ELISA was used to measure TCC in EDTA plasma. The patients were examined at baseline, after 6 weeks and 6 months of treatment. Results Median TCC was 1.10 CAU/mL, and 57 (89%) patients had TCC above the estimated upper reference limit (<0.70). Compared to baseline, TCC levels were significantly lower at 6-week visit (0.85 CAU/mL, p<0.0001), without significant differences between the two treatment regimens. Notably, sustained reduction in TCC was only achieved after 6 months on TNFi±MTX (0.80 CAU/mL, p = 0.006). Reductions in TCC after treatment were related to decreased C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and interleukin 6, and increased levels of total, high and low-density lipoprotein cholesterol. Similarly, baseline TCC was significantly related to baseline CRP, ESR and interleukin 6. Patients with endothelial dysfunction had higher baseline TCC than those without (median 1.4 versus 1.0 CAU/mL, p = 0.023). Conclusions Patients with active RA had elevated TCC, indicating increased complement activation. TCC decreased with antirheumatic treatment already after 6 weeks. However, only treatment with TNFi±MTX led to sustained reduction in TCC during the 6-month follow-up period. RA patients with endothelial dysfunction had higher baseline TCC compared to those without, possibly reflecting involvement of complement in the atherosclerotic process in RA.
Seed priming improved salt-stressed sorghum growth by enhancing antioxidative defense

Seed priming is regarded as a beneficial and effective method enhancing performance of plants grown under stress conditions. This study illustrated the effect of four seed priming agents (2% H2O2, 52 mM NaCl, 50 mM KCl, 250 mM MgSO4) on two sorghum cultivars (Canada sorghum CFSH-30 and sorghum ‘1230’) grown in saline soils. Sorghum growth characteristics and biochemical parameters were investigated. Seed priming treatments alleviated the adverse effects of salt stress by decreasing MDA content and enhancing antioxidant enzymes (CAT, POD and SOD) activities and proline content, and hence increased sorghum fresh and dry weight. In terms of various parameters, sorghum ‘1230’ was more suitable to be grown in saline soil, and 52 mM NaCl and 50 mM KCl were the optimum priming agents to improve the performance of salt-stressed sorghum.
Rapid Detection of Genotype II African Swine Fever Virus Using CRISPR Cas13a-Based Lateral Flow Strip

The African swine fever virus (ASFV) is a dsDNA virus that can cause serious, highly infectious, and fatal diseases in wild boars and domestic pigs. The ASFV has brought enormous economic loss to many countries, and no effective vaccine or treatment for the ASFV is currently available. Therefore, the on-site rapid and accurate detection of the ASFV is key to the timely implementation of control. The RNA-guided, RNA-targeting CRISPR effector CRISPR-associated 13 (Cas13a; previously known as C2c2) exhibits a “collateral effect” of promiscuous RNase activity upon the target recognition. The collateral cleavage activity of LwCas13a is activated to degrade the non-targeted RNA, when the crRNA of LwCas13a binds to the target RNA. In this study, we developed a rapid and sensitive ASFV detection method based on the collateral cleavage activity of LwCas13a, which combines recombinase-aided amplification (RAA) and a lateral flow strip (named CRISPR/Cas13a-LFD). The method was an isothermal detection at 37 °C, and the detection can be used for visual readout. The detection limit of the CRISPR/Cas13a-LFD was 101 copies/µL of p72 gene per reaction, and the detection process can be completed within an hour. The assay showed no cross-reactivity to eight other swine viruses, including classical swine fever virus (CSFV), and has a 100% coincidence rate with real-time PCR detection of the ASFV in 83 clinical samples. Overall, this method is sensitive, specific, and practicable onsite for the ASFV detection, showing a great application potential for monitoring the ASFV in the field.
Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management

Atherosclerotic cardiovascular disease (ASCVD) stands amongst the leading causes of mortality worldwide and has attracted the attention of world's leading pharmaceutical companies in order to tackle such mortalities. The low-density lipoprotein-cholesterol (LDL-C) is considered the most prominent biomarker for the assessment of ASCVD risk. Distinct inhibitors of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-R), the chief hepatic cholesterogenic enzyme, are being used since last seven decades to manage hypercholesterolemia. On the other hand, discovery and the association of proprotein convertase subtilisin/kexin type-9 (PCSK-9) with increased ASCVD risk have established PCSK-9 as a novel therapeutic target in cardiovascular medicine. PCSK-9 is well reckoned to facilitate the LDL-receptor (LDL-R) degradation and compromised LDL-C clearance leading to the arterial atherosclerotic plaque formation. The currently available HMG-R inhibitors (statins) and PCSK-9 inhibitors (siRNA, anti-sense oligonucleotides, and monoclonal antibodies) have shown great promises in achieving LDL-C lowering goals, however, their life long prescriptions have raised significant concerns. These deficits associated with the synthetic HMG-R and PCSK-9 inhibitors called for the discovery of alternative therapeutic candidates with potential dual HMG-R and PCSK-9 inhibitory activities from natural origins. Therefore, this report firstly describes the mechanistic insights into the cholesterol homeostasis through HMG-R, PCSK-9, and LDL-R functionality and then compiles the pharmacological effects of natural secondary metabolites with special emphasis on their dual HMG-R and PCSK-9 inhibitory action. In conclusion, various natural products exhibit atheroprotective effects via targeting HMG-R and PCSK-9 activities and lipoprotein metabolism, however, further clinical assessments are still warranted prior their approval for ASCVD risk management in hypercholesterolemic patients.
Integral equation solutions for the average run length for monitoring shifts in the mean of a generalized seasonal ARFIMAX(P, D, Q, r)s process running on a CUSUM control chart

The CUSUM control chart is suitable for detecting small to moderate parameter shifts for processes involving autocorrelated data. The average run length (ARL) can be used to assess the ability of a CUSUM control chart to detect changes in a long-memory seasonal autoregressive fractionally integrated moving average with exogenous variable (SARFIMAX) process with underlying exponential white noise. Herein, new ARLs via an analytical integral equation (IE) solution as an analytical IE and a numerical IE method to test a CUSUM control chart’s ability to detect a wide range of shifts in the mean of a SARFIMAX(P, D, Q, r)s process with underlying exponential white noise are presented. The analytical IE formulas were derived by using the Fredholm integral equation of the second type while the numerical IE method for the approximate ARL is based on quadrature rules. After applying Banach’s fixed-point theorem to guarantee its existence and uniqueness, the precision of the proposed analytical IE ARL was the same as the numerical IE method. The sensitivity and accuracy of the ARLs based on both methods were assessed on a CUSUM control chart running a SARFIMAX(P, D, Q, r)s process with underlying exponential white noise. The results of an extensive numerical study comprising the examination of a wide variety of out-of-control situations and computational schemes reveal that none of the methods outperformed the IE. Specifically, the computational scheme is easier and can be completed in one step. Hence, it is recommended for use in this situation. An illustrative example based on real data is also provided, the results of which were found to be in accordance with the research results.
Infantile subdural hematoma in Japan: A multicenter, retrospective study by the J-HITs (Japanese head injury of infants and toddlers study) group

Objective Subdural hematoma in infants or toddlers has often been linked to abuse, but it is not clear how many cases actually occur and how many are suspected of abuse. The purpose of this study was to investigate subdural hematoma in infants and toddlers in Japan. Methods This multicenter, retrospective study reviewed the clinical records of children younger than 4 years with head trauma who were diagnosed with any finding on head computed tomography (CT) and/or magnetic resonance imaging (MRI), such as skull fracture and/or intracranial injury. A total of 452 children were included. The group suspected to have been abused was classified as nonaccidental, and the group considered to have been caused by an accident was classified as accidental. Subdural hematoma and other factors were examined on multivariate analysis to identify which factors increase the risk of nonaccidental injuries. Results Of the 452 patients, 158 were diagnosed with subdural hematoma. Subdural hematoma was the most common finding intracranial finding in head trauma in infants and toddlers. A total of 51 patients were classified into the nonaccidental group, and 107 patients were classified into the accidental group. The age of patients with subdural hematoma showed a bimodal pattern. The mean age of the accidental group with subdural hematoma was significantly older than that in the nonaccidental group (10.2 months vs 5.9 months, respectively. p < 0.001). Multivariate analysis showed that patients under 5 months old, retinal hemorrhage, and seizure were significant risk factors for nonaccidental injury (odds ratio (OR) 3.86, p = 0.0011; OR 7.63, p < 0.001; OR 2.49, p = 0.03; respectively). On the other hand, the odds ratio for subdural hematoma was 1.96, and no significant difference was observed (p = 0.34). Conclusions At least in Japanese children, infantile subdural hematoma was frequently observed not only in nonaccidental but also in accidental injuries. In infants with head trauma, age, the presence of retinal hemorrhage, and the presence of seizures should be considered when determining whether they were abused. Subdural hematoma is also a powerful finding to detect abuse, but care should be taken because, in some ethnic groups, such as the Japanese, there are many accidental cases.