Miracle-dz/UniFAR-FTUs huggingface dataset:
Increasing tidal inundation corresponds to rising porewater nutrient concentrations in a southeastern U.S. salt marsh

Salt marshes are ecologically and economically important features of coastal environments that are vulnerable to sea level rise, the rate of which has accelerated in recent decades along the southeastern US Atlantic coast. Increased flooding frequency and duration across the marsh platform is predicted to impact vegetation community structure and overall marsh persistence, but the effect of changing inundation patterns on biogeochemical processes in marsh sediments remains largely unexplored. As part of a long-term monitoring effort to assess how marshes are responding to sea level rise in North Inlet estuary (South Carolina, USA), we collected data on porewater nutrient concentrations from a series of permanent monitoring plots across multiple transects spanning the marsh elevation gradient during the growing season from 2009 to 2019. Additionally, we calculated time inundated for each plot using local water level data and high-resolution elevation measurements to assess the change in time flooded at each plot. Our results indicate that both NH4 and PO4 nutrient concentrations have increased in most permanent plots over the 11-year study period and that nutrient concentrations are higher with increasing proximity to the creek. Spatial patterns in nutrient increases through time are coincident with considerable increases in tidal inundation observed over the marsh platform. Across plots located in the low marsh, porewater NH4 and PO4 concentrations have risen at average rates of 8.96 μM/year and 0.86 μM/year, respectively, and have reached rates as high as 27.25 μM/year and 3.13 μM/year. We suggest that increased inundation time due to rising sea level has altered biogeochemical conditions influencing nutrient availability in marsh porewater, resulting in increases that likely have relevance for larger scale nutrient cycles as well as marsh ecosystem stability and function.
Impairments in Emotion Recognition and Positive Emotion Regulation Predict Social Difficulties in Adolescent With ADHD

Background Emotional dysregulation, poor emotion recognition and impaired response inhibition have been highlighted as potential contributors to social difficulties in adolescents with attention-deficit/hyperactivity disorder (ADHD). It is currently unknown how these areas of impairment relate to one another; therefore, this study aims to identify the areas of emotion regulation which are associated with social difficulties in adolescents with ADHD, and determine whether emotion regulation mediates the relationship between deficits in response inhibition and emotion recognition, and social functioning, in this cohort. Methods Thirty Australian adolescents (Male = 21) with ADHD completed measures of response inhibition, emotion recognition, and emotion regulation. Results Positive emotion regulation was significantly associated with social difficulties. Although emotion recognition significantly predicted social difficulties, there was no relationship between emotion recognition and emotion regulation in this sample, ruling out emotion regulation as a mediator of emotion recognition and social difficulties. Whilst response inhibition was significantly correlated with positive emotion regulation, positive emotion regulation did not mediate the relationship between response inhibition and social difficulties. Conclusions Difficulties recognising and regulating emotions appear to independently contribute to social difficulties in adolescents with ADHD. Interventions to increase emotional understanding and developing strategies to down-regulate positive emotions may be beneficial.
Biomarker diversity in increased inflammation: Secondary hemophagocytic syndrome vs. systemic inflammatory response syndrome

Secondary hemophagocytic syndrome (HPS) and systemic inflammatory response syndrome (SIRS) share similar clinical findings as a result of hyperinflammation. Due to high mortality rates in HPS; it is critical to diagnose promptly. Thus, this study aimed to evaluate the diagnostic and prognostic significance of inflammatory markers in these two increased inflammatory states.
A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells

N6-methyladenosine (m6A) modification of RNA regulates normal and cancer biology, but knowledge of its function on long noncoding RNAs (lncRNAs) remains limited. Here, we reveal that m6A regulates the breast cancer-associated human lncRNA HOTAIR. Mapping m6A in breast cancer cell lines, we identify multiple m6A sites on HOTAIR, with 1 single consistently methylated site (A783) that is critical for HOTAIR-driven proliferation and invasion of triple-negative breast cancer (TNBC) cells. Methylated A783 interacts with the m6A “reader” YTHDC1, promoting chromatin association of HOTAIR, proliferation and invasion of TNBC cells, and gene repression. A783U mutant HOTAIR induces a unique antitumor gene expression profile and displays loss-of-function and antimorph behaviors by impairing and, in some cases, causing opposite gene expression changes induced by wild-type (WT) HOTAIR. Our work demonstrates how modification of 1 base in an lncRNA can elicit a distinct gene regulation mechanism and drive cancer-associated phenotypes.
The flow of water through the straits of Dover, related to wind and differences in sea level

The difference in electric potential between the water on opposite sides of the English Channel, as recorded on a telephone cable running from St Margaret’s Bay to Sangatte, has been used to measure the mean flow of water through the Straits of Dover. The records were calibrated by means of the tidal currents, which were know from previous measurements. A p.d. of 1 V corresponds to a current of about 140 cm /s (2.75 knots), the exact calibration depending on the electrical conductivity o f the sea water and having a seasonal variation. Continuous records were obtained during the 15-month period from February 1953 to June 1954. For 4 months, from November 1953 to March 1954, similar records were also obtained on an other cable, crossing the southern North Sea from Aldeburgh to Domburg. Fluctuations due to the Earth currents associated with geomagnetic disturbances occurred from time to time, but did not usually cause any difficulty in in terpretin g the records. The residual flow, after eliminating the tidal currents, has been correlated with the local wind in the Straits and the difference in sea level between the eastern p a rt of the English Channel and the southern part of the North Sea, as determined from tide-gauge records. The tidal currents and elevations were eliminated, approximately, by taking means of 25 hourly readings centred at noon, for each day of the period covered by the observations. The greatest daily rates of flow recorded w ere 79 cm/s (T53 knots) towards the north-east on 1 November 1953 an d 77 cm /s (T49 knots) towards the south-w est on 3 January 1954. F or three periods of un usually strong flow, namely, 19 to 24 September 1953, 26 October to 8 November 1953, and 1 to 6 January 1954, a more detailed analysis was made, eliminating the tidal effects by a method previously used in the analysis of storm surges. The results show the existence of ‘current surges’, the peaks of which lag by up to 6 h behind the corresponding max im a in the wind stress or surface gradient producing them . An attempt has been made to relate the empirical results to the dynamics of flow through the Straits. On the assumption that the 25 h means can be regarded as referring to steady-state conditions, values o f 4-5 x 10-3 for the w ind-stress coefficient y 2 an d 3-8 x 10-3 for the bottom friction coefficient k have been deduced. These rather high values may be due, in part, to the steady-state assumption not being justified. The general features of the current surges are consistent with the dynamical treatment.
The critical function for the semistandard map

For the semistandard map F(x,y)=(x+y+ieix, y+ieix), we consider the critical function Kss( omega ), defined as the radius of convergence of a series expansion of a complex invariant curve of rotation number omega , and show that log Kss( omega )+2 Sigma qk-1 log qk+1 is bounded on the set of omega where it is well-defined, where (qk) are the denominators of the convergents to the real number omega . We discuss the implications for critical functions for the standard map.
Mapping the Complete Photocycle that Powers a Large Stokes Shift Red Fluorescent Protein.

Large Stokes shift (LSS) red fluorescent proteins (RFPs) are highly desirable for bioimaging advances. The RFP mKeima, with coexisting cis- and trans-isomers, holds significance as an archetypal system for LSS emission due to excited-state proton transfer (ESPT), yet the mechanisms remain elusive. We implemented femtosecond stimulated Raman spectroscopy (FSRS) and various time-resolved electronic spectroscopies, aided by quantum calculations, to dissect the cis- and trans-mKeima photocycle from ESPT, isomerization, to ground-state proton transfer in solution. This work manifests the power of FSRS with global analysis to resolve Raman fingerprints of intermediate states. Importantly, the deprotonated trans-isomer governs LSS emission at 620 nm, while the deprotonated cis-isomer's 520 nm emission is weak due to an ultrafast cis-to-trans isomerization. Complementary spectroscopic techniques as a table-top toolset are thus essential to study photochemistry in physiological environments.
SPECKLE INTERFEROMETRY AT SOAR IN 2010 AND 2011: MEASURES, ORBITS, AND RECTILINEAR FITS

We report on the results of speckle observations at the 4.1 m SOAR telescope in 2010 and 2011. A total of 639 objects were observed. We give 562 measurements of 418 resolved binaries, including 21 pairs resolved for the first time, and upper detection limits for 221 unresolved stars. New orbital elements have been determined for 42 physical pairs, of which 22 are first-time calculations; the rest are corrections, sometimes substantial. Linear elements are calculated for nine apparently optical doubles. We comment on new pairs, new orbital solutions, and other remarkable objects.
Long-term Outcomes in Use of Opioids, Nonpharmacologic Pain Interventions, and Total Costs of Spinal Cord Stimulators Compared With Conventional Medical Therapy for Chronic Pain.

Importance Spinal cord stimulators (SCSs) are increasingly used for the treatment of chronic pain. There is a need for studies with long-term follow-up. Objective To determine the comparative effectiveness and costs of SCSs compared with conventional medical management (CMM) in a large cohort of patients with chronic pain. Design, Setting, and Participants This was a 1:5 propensity-matched retrospective comparative effectiveness research analysis of insured individuals from April 1, 2016, to August 31, 2018. This study used administrative claims data, including longitudinal medical and pharmacy claims, from US commercial and Medicare Advantage enrollees 18 years or older in Optum Labs Data Warehouse. Patients with incident diagnosis codes for failed back surgery syndrome, complex regional pain syndrome, chronic pain syndrome, and other chronic postsurgical back and extremity pain were included in this study. Data were analyzed from February 1, 2021, to August 31, 2022. Exposures SCSs or CMM. Main Outcomes and Measures Surrogate measures for primary chronic pain treatment modalities, including pharmacologic and nonpharmacologic pain interventions (epidural and facet corticosteroid injections, radiofrequency ablation, and spine surgery), as well as total costs. Results In the propensity-matched population of 7560 patients, mean (SD) age was 63.5 (12.5) years, 3080 (40.7%) were male, and 4480 (59.3%) were female. Among matched patients, during the first 12 months, patients treated with SCSs had higher odds of chronic opioid use (adjusted odds ratio [aOR], 1.14; 95% CI, 1.01-1.29) compared with patients treated with CMM but lower odds of epidural and facet corticosteroid injections (aOR, 0.44; 95% CI, 0.39-0.51), radiofrequency ablation (aOR, 0.57; 95% CI, 0.44-0.72), and spine surgery (aOR, 0.72; 95% CI, 0.61-0.85). During months 13 to 24, there was no significant difference in chronic opioid use (aOR, 1.06; 95% CI, 0.94-1.20), epidural and facet corticosteroid injections (aOR, 1.00; 95% CI, 0.87-1.14), radiofrequency ablation (aOR, 0.84; 95% CI, 0.66-1.09), or spine surgery (aOR, 0.91; 95% CI, 0.75-1.09) with SCS use compared with CMM. Overall, 226 of 1260 patients (17.9%) treated with SCS experienced SCS-related complications within 2 years, and 279 of 1260 patients (22.1%) had device revisions and/or removals, which were not always for complications. Total costs of care in the first year were $39 000 higher with SCS than CMM and similar between SCS and CMM in the second year. Conclusions and Relevance In this large, real-world, comparative effectiveness research study comparing SCS and CMM for chronic pain, SCS placement was not associated with a reduction in opioid use or nonpharmacologic pain interventions at 2 years. SCS was associated with higher costs, and SCS-related complications were common.
TRAPPC1 is essential for the maintenance and differentiation of common myeloid progenitors in mice

Myeloid cell development in bone marrow is essential for the maintenance of peripheral immune homeostasis. However, the role of intracellular protein trafficking pathways during myeloid cell differentiation is currently unknown. By mining bioinformatics data, we identify trafficking protein particle complex subunit 1 (TRAPPC1) as continuously upregulated during myeloid cell development. Using inducible ER‐TRAPPC1 knockout mice and bone marrow chimeric mouse models, we demonstrate that TRAPPC1 deficiency causes severe monocyte and neutrophil defects, accompanied by a selective decrease in common myeloid progenitors (CMPs) and subsequent cell subsets in bone marrow. TRAPPC1‐deleted CMPs differentiate poorly into monocytes and neutrophils in vivo and in vitro, in addition to exhibiting enhanced endoplasmic reticulum stress and apoptosis via a Ca2+‐mitochondria‐dependent pathway. Cell cycle arrest and senescence of TRAPPC1‐deleted CMPs are mediated by the activation of pancreatic endoplasmic reticulum kinase and the upregulation of cyclin‐dependent kinase inhibitor p21. This study reveals the essential role of TRAPPC1 in the maintenance and differentiation of CMPs and highlights the significance of protein processing and trafficking processes in myeloid cell development.
Different Instruments, Same Content? A Systematic Comparison of Child Maltreatment and Harsh Parenting Instruments

Child maltreatment and harsh parenting both include harmful actions by parents toward children that are physical (e.g., spanking, slapping) or emotional (e.g., threatening, yelling). The distinction between these two constructs, in meaning and measurement, is often unclear, leading to inconsistent research and policy. This study systematically identified, reviewed, and compared parent-reported child maltreatment (N = 7) and harsh parenting (N = 18) instruments. The overlap in parenting behaviors was 73%. All physical behaviors that were measured in harsh parenting instruments (e.g., spanking, beating up) were also measured in child maltreatment instruments. Unique physical behaviors measured in maltreatment instruments include twisting body parts and choking. All emotional behaviors in maltreatment instruments were included in harsh parenting instruments, and vice versa. Our findings suggest similar, but not identical, operationalizations of child maltreatment and harsh parenting. Our findings can help guide discussions on definitions, operationalizations, and their consequences for research on violence against children.
Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis

Cocaine abuse has a negative impact on the immune system. To investigate the adverse effects of binge cocaine administration on lymphoid organs such as thymus and spleen, we examined the effects of repeated intravenous (i.v.) administration of cocaine on rats. Sprague Dawley rats (male, 8 weeks old) received 20 mg/kg body weight of cocaine hydrochloride per day for 7 or 14 days. In addition to a significant loss in the weight of the spleen, consistent with our previous intraperitoneal (i.p.) injection model of binge cocaine abuse (50 mg/kg cocaine for 7 days), we also found a significant loss of weight as well as apparent shrinkage of the thymus in the cocaine group. Transcriptome analysis of the thymus revealed increased expressions of genes involved in apoptosis, such as Ifi27 and Traf2, as well as decreased expressions of several genes related to lipid metabolism, such as Cd36, Adipoq, Scd1, and Fabp4, in the thymus of the cocaine group (7 days), suggesting an apoptotic loss of thymic cells as well as alterations in lipid metabolism. Paradoxically, cocaine activates PPARγ, a key transcriptional factor activating lipid metabolism, although ectopic adipogenesis was scarcely observed in the thymus. Further analysis of rats administered 20 mg/kg cocaine for 14 days revealed ectopic adipogenesis, which was accompanied with the activation of PPARγ as well as increased expression of Adipoq and Fabp4, in the thymus. Taken together, these results indicate that repeated cocaine administration induces thymic involution, which is initiated by the loss of thymic cells through apoptosis and subsequent ectopic adipocyte development.
Aging and solid or liquid behavior in pastes

We carried out systematic creep tests after different times of rest and over sufficiently long times with pasty materials of various internal structures in a Couette geometry. From an analysis of the data taking into account the inertia of the system and the heterogeneous distribution of stress, we show that: (i) for a stress below the yield stress these materials remain solid but undergo residual, irreversible deformations over long time which exhibit some trends typical of aging in glassy systems; (ii) as a result of thixotropy (or aging) in the solid regime the elastic modulus increases logarithmically with the time of rest; (iii) in the liquid regime the effective behavior of the material can be well represented by a truncated power-law model; (iv) a fundamental parameter of the solid-liquid transition is a critical effective shear rate (associated with the yield stress) below which the material cannot flow steadily.
Global prevalence of intellectual developmental disorder in dystrophinopathies: A systematic review and meta‐analysis

To estimate the global prevalence of intellectual developmental disorder (IDD) and the IDD prevalence–genotype association in Becker muscular dystrophy (BMD) or Duchenne muscular dystrophy (DMD) according to the affected isoforms of the DMD gene: Dp427, Dp140, Dp71.
Influence of shoe torsional stiffness on foot and ankle biomechanics during tennis forehand strokes

ABSTRACT Tennis shoe characteristics need to minimise the risk of athletes suffering ankle injuries and improve players’ feet performance. This study aims to evaluate the influence of shoe torsional stiffness on running velocity, stance duration, ground reaction forces and ankle biomechanics during two different tennis forehand runs and strokes. Ten right-handed advanced male tennis players performed two specific tennis forehand runs and strokes at maximal effort (a shuttle run with a defensive open stance forehand – SRDF and a lateral jab run with an offensive open stance forehand - JROF) with four different pairs of tennis shoes with different torsional stiffness. A force platform measured ground reaction forces (GRF). A motion capture system recorded the 3D trajectories of markers located on players’ anatomical landmarks. The minimum, maximum angle value, and range of motion were computed using inverse kinematics for each rotation axis of the right ankle. Normalised maximal ankle torques were also computed using inverse dynamics. Shoe torsional stiffness had no effect on running velocity, on stance duration and maximal values of GRF. Shoe torsional stiffness influenced forefoot inversion which was significantly higher for the most flexible shoes. For SRDF, the maximal ankle inversion angle was significantly and largely increased for the stiffest shoe. The stiffest shoe may put the ankle at a higher risk of lateral sprains during SRDF while it was not the case during JROF. Highlights Shoe torsional stiffness has no effect on performance parameters (running velocity of the centre of mass, ground reaction forces, and stance duration) during tennis forehand strokes. Decreased shoe torsional stiffness increased the maximal forefoot inversion angle and the range of motion of forefoot inversion–eversion during tennis forehand strokes and movements. Increased footwear torsional stiffness causes higher maximal ankle inversion angle which may increase the risk for ankle sprains in SRDF.
How to Address the Health of Home Care Workers: A Systematic Review of the Last Two Decades

Making home care a healthy workplace is a societal concern but research on specific interventions is still scarce. The aim of this systematic review was to provide an initial overview of interventions addressing home care workers’ health. All (quasi-) experimental studies, presenting any intervention among home care employees, and reporting any outcome related to occupational health, safety, or well-being were included. PsycArticles, Medline, PubMed, and Web of Science were searched from January 2000 to February 2022. From 16,345 publications, 18 studies with 2432 participants were included and assessed with the Joanna Briggs Institute Critical Appraisal Tools. Organizational and training/educational approaches were found in five studies each, a behavioral approach in one, and seven studies presented a combined approach. Due to methodological limitations and the heterogeneity of interventions, the existing studies are insufficient to inform new programs, but emphasize the need for tailored approaches, integrated concepts, and participatory intervention development.
A note on the distribution of mean square error of forecasting

Simulation has been a very important and widely used method in the study of misspecification or order determination in time series analysis. Mean square error of forecasting (MSEF) has been a major criterion for comparing the performance of different models. In simulation studies, standard deviations of MSEF's are calculated from the computed values of the MSEF's, In this note, the distribution of MSEF from simulation studies is established. Exact variance of the MSEF can be obtained from the prespecified values of the model selected for simulation. This variance should be a more appropriate criterion for evaluating the performance between models.