Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of thinness, overweight and obesity among Tibetan adolescents aged 12–17 years

Abstract Objective: To estimate the prevalence of thinness, overweight and obesity among Tibetan adolescents aged 12–17 years. Design: Cross-sectional survey. Setting: Shigatse City of Tibet municipality, with an average altitude of more than 4000 m. Participants: Study participants included 2642 adolescents aged 12–17 years selected from six schools using a convenient cluster sampling method. Results: The prevalence of thinness/overweight/obesity among Tibetan adolescents was 9·4 %/5·4 %/1·4 % (China definition), 14·7 %/4·4 %/0·7 % (International Obesity Task Force (IOTF) definition), and 2·8 %/5·7 %/0·9 % (WHO definition). The prevalence of thinness and overweight was significantly different between both sexes based on each of three BMI classification criteria (P < 0·001). There was no significant difference in the prevalence of obesity between both sexes according to each of three BMI criteria. There was no clear trend in the prevalence of thinness across ages according to the China or IOTF definition (both P > 0·05), whereas an upward trend was observed for thinness in boys according to the IOTF definition (P for trend <0·05). In contrast, the prevalence of thinness tended to decrease with increasing age in girls according to the IOTF definition and in total sample according to the WHO definition (P for trend <0·05). Conclusions: Among Tibetan adolescents, the prevalence of overweight and obesity is relatively low, while the prevalence of thinness is high, especially in boys. These data suggest urgent attention is needed to control adolescent thinness in Tibet.
Efficacy of two-way prayer meditation in improving the psychospiritual well-being of people with substance use disorders: A pilot randomized controlled trial

Background The study goal was to conduct a preliminary evaluation of a spiritual intervention called Two Way Prayer Meditation's (TWPM) effectiveness on the psychological distress, self-esteem, and spiritual well-being of people with substance use disorders. Methods This study employed a randomized controlled trial design with pretest and posttest. In total, 134 adults in four residential recovery programs participated in the study and were randomly assigned to either the TWPM group or the treatment as usual group. Primary and sensitivity analyses were conducted using linear mixed modeling. Hedges's g was used to estimate treatment effect sizes. Results Both primary and sensitivity analyses found significant treatment effects on daily spiritual experiences (Hedges's g = 0.62), reliance on God (g = 0.49), private religious practice (g = 0.36), and positive religious/spiritual coping (g = 0.68). Treatment effects on psychological distress (g = 0.33), self-esteem (g = 0.41), and overall spirituality self-ranking (g = 0.32) reached significance in the primary analysis but not in the sensitivity analysis. Conclusions This study found evidence of TWPM's effectiveness in improving some aspects of the spiritual well-being of adults with substance use disorders. TWPM was also found to be promising in decreasing psychological distress and increasing self-esteem.
Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS

Preclinical studies show a link between subthalamic nucleus (STN) deep brain stimulation (DBS) and neuroprotection of nigrostriatal dopamine (DA) neurons, potentially through brain-derived neurotrophic factor (BDNF) signaling. However, the question of whether DBS of the STN can be disease-modifying in Parkinson's disease (PD) remains unanswered. In particular, the impact of STN DBS on α-synuclein (α-syn) aggregation, inclusion-associated neuroinflammation, and BDNF levels has yet to be examined in the context of synucleinopathy. To address this, we examined the effects of STN DBS on BDNF using the α-syn preformed fibril (PFF) model in male rats. While PFF injection resulted in accumulation of phosphorylated α-syn (pSyn) inclusions in the substantia nigra pars compacta (SNpc) and cortical areas, STN DBS did not impact PFF-induced accumulation of pSyn inclusions in the SNpc. In addition, nigral pSyn inclusions were associated with increased microgliosis and astrogliosis; however, the magnitude of these processes was not altered by STN DBS. Total BDNF protein was not impacted by pSyn inclusions, but the normally positive association of nigrostriatal and corticostriatal BDNF was reversed in rats with PFF-induced nigrostriatal and corticostriatal inclusions. Despite this, rats receiving both STN DBS and PFF injection showed increased BDNF protein in the striatum, which partially restored the normal corticostriatal relationship. Our results suggest that pathologic α-syn inclusions disrupt anterograde BDNF transport within nigrostriatal and corticostriatal circuitry. Further, STN DBS has the potential to exert protective effects by modifying the long-term neurodegenerative consequences of synucleinopathy. SIGNIFICANCE STATEMENT An increase in brain-derived neurotrophic factor (BDNF) has been linked to the neuroprotection elicited by subthalamic nucleus (STN) deep brain stimulation (DBS) in neurotoxicant models of Parkinson's disease (PD). However, whether STN DBS can similarly increase BDNF in nigrostriatal and corticostriatal circuitry in the presence of α-synuclein (α-syn) inclusions has not been examined. We examined the impact of STN DBS on rats in which accumulation of α-syn inclusions is induced by injection of α-syn preformed fibrils (PFFs). STN DBS significantly increased striatal BDNF protein in rats seeded with α-syn inclusions and partially restored the normal corticostriatal BDNF relationship. These findings suggest that STN DBS can drive BDNF in the parkinsonian brain and retains the potential for neuroprotection in PD.
Linking field and laboratory studies: Reproductive effects of perfluorinated substances on avian populations

Although both laboratory and field studies are needed to effectively assess effects and risk of contaminants to free‐living organisms, the limitations of each must be understood. The objectives of this paper are to examine information on field studies of reproductive effects of perfluorinated substances (PFASs) on bird populations, discuss the differences among field studies, and then place those results in context with laboratory studies. Hypotheses to explain the divergences between field studies and between laboratory and field studies will be discussed. Those differences include mixture issues, misattribution of the mechanism or the specific PFAS causing impairments, as well as other possible reasons. Finally, suggestions to better link laboratory and field studies will be presented. Integr Environ Assess Manag 2021;17:690–696. Published 2021. This article is a US Government work and is in the public domain in the USA.
Loop‐mediated isothermal amplification (LAMP): An effective molecular point‐of‐care technique for the rapid diagnosis of coronavirus SARS‐CoV‐2

The novel coronavirus disease‐2019 (Covid‐19) public health emergency has caused enormous loss around the world. This pandemic is a concrete example of the existing gap between availability of advanced diagnostics and current need for cost‐effective methodology. The advent of the loop‐mediated isothermal amplification (LAMP) assay provided an innovative tool for establishing a rapid diagnostic technique based on the molecular amplification of pathogen RNA or DNA. In this review, we explore the applications, diagnostic effectiveness of LAMP test for molecular diagnosis and surveillance of severe acute respiratory syndrome coronavirus 2. Our results show that LAMP can be considered as an effective point‐of‐care test for the diagnosis of Covid‐19 in endemic areas, especially for low‐ and middle‐income countries.
Cardiac involvement in consecutive elite athletes recovered from Covid‐19: A magnetic resonance study

Magnetic resonance (MR) studies suggested cardiac involvement post‐Covid‐19 in a significant subset of affected individuals, including athletes. This brings serious clinical concerns regarding the potential need for in‐depth cardiac screening in athletes after Covid‐19 before return to play. The aim of this study was to gain further insight into the relation between Covid‐19 and cardiac involvement in professional athletes. This was a retrospective cohort study, in which 26 consecutive elite athletes (national team, Olympians, top national league players; median age 24 years, interquartile range [IQR] 21–27, 81% female) were included. At 1.5 T including balanced steady‐state free precession cine imaging, T1 and T2‐mapping using Myomaps software (Siemens), dark‐blood T2‐weighted images with fat suppression, and late gadolinium enhancement (LGE) with phase‐sensitive inversion recovery sequence were used. The athletes had mainly asymptomatic or mild course of the disease (77%). They were scanned after a median of 32 days (IQR 22–62 days) from the diagnosis. MR data were reviewed by three independent observers, each with >10 years cardiac MR experience. Native T1, T2, extracellular volume, and T2 signal intensity ratio were calculated. Diagnosis of acute myocarditis was based on modified Lake Louise criteria. Statistical analyses used were Pearson correlation and Bland–Altman repeatability analysis. At the time of MR the athletes had no pathologic electrocardiogram abnormalities or elevated troponin levels. MR did not reveal any case of acute myocarditis. Cardiac abnormalities were found in five (19%) athletes, including four athletes presenting borderline signs of isolated myocardial edema and one athlete showing nonischemic LGE with pleural and pericardial effusion. Another athlete had signs of persistent lung congestion without cardiac involvement. We have shown that in a small group of elite athletes with mainly asymptomatic to mild Covid‐19, lack of electrocardiographic changes, and normal troponin concentration 1–2 months after the diagnosis, there were no signs of acute myocarditis, but 19% of athletes had some abnormalities as assessed by cardiac MR.
Vortices Induced in a Jet by a Subsonic Cross Flow

pressures and temperatures during the central portion of the cycle but decreases them during the last 35% of the cycle; increasing the effusion parameter K decreases the pressures and temperatures during all parts of the cycle. The beam density at the detector was calculated numerically for both Eqs. (7) and (11). Typical predicted values are compared with measured values in Fig. 1. The results justify the use of the simplified model for cases in which the most probable time of flight is less than about 5% of the cycle period. J5. Experimental results Data taken to demonstrate the increasing skimmer-interference effects due to increasing mass-flow rates are presented in Figs. 2a-2c. It is seen that the beam density decreases dramatically, particularly in the vicinity of the top dead center, as the mass-flow rate increases. An analysis of source-chamber flows indicates that the observed lag of the source-chamber pressure peak behind the source pressure peak is determined by the ratio of the booster-pump characteristic time and the source-cycle period. The smaller source-chamber pressure peak appearing in the early part of the cycle is due to a superpositioning of residual gas from the previous cycle and gas from the present cycle. Consequences of varying the nozzle-skimmer distance x are shown in Fig. 3. For small nozzle-skimmer distances, strong skimmer interference occurs near the peak density of the cycle; for large nozzle-skimmer distances, the beam density is attenuated throughout the cycle. Beam densities observed for three different engine speeds are compared in Fig. 4. It is seen that the peak beam density increases with engine speed, which speed is inversely proportional to the effusion parameter K. Discussions Agreement between the measured and predicted signals is good except near the end of the cycle (see Fig. 1). The relatively low beam density observed near the end of the cycle might be due to background scattering resulting from the relatively high source-chamber background density during this part of the cycle.
Viral infections and implications for male reproductive health

Viral infections have haunted humankind since times immemorial. Overpopulation, globalization, and extensive deforestation have created an ideal environment for a viral spread with unknown and multiple shedding routes. Many viruses can infect the male reproductive tract, with potential adverse consequences to male reproductive health, including infertility and cancer. Moreover, some genital tract viral infections can be sexually transmitted, potentially impacting the resulting offspring's health. We have summarized the evidence concerning the presence and adverse effects of the relevant viruses on the reproductive tract (mumps virus, human immunodeficiency virus, herpes virus, human papillomavirus, hepatitis B and C viruses, Ebola virus, Zika virus, influenza virus, and coronaviruses), their routes of infection, target organs and cells, prevalence and pattern of virus shedding in semen, as well as diagnosis/testing and treatment strategies. The pathophysiological understanding in the male genital tract is essential to assess its clinical impact on male reproductive health and guide future research.
The mediating effect of conscientiousness on the academic consequences of social jetlag

ABSTRACT Social jetlag (SJL) causes impairment of academic achievement; on the other hand, the personality factor of conscientiousness is related to better grades. We evaluated the impact of conscientiousness on the academic consequences of social jetlag. Undergraduate students (n = 556) were evaluated throughout their first 3 years of university education. Conscientiousness, as a mediating factor in the structural equation modeling, explained 20% of the effect of SJL on academic achievement. This is the first cohort study to evaluate the mediating effect of personality on the consequences of SJL.
Teaching About Racism in Medical Education: A Mixed-Method Analysis of a Train-the-Trainer Faculty Development Workshop.

BACKGROUND AND OBJECTIVES Curriculum addressing racism as a driver of inequities is lacking at most health professional programs. We describe and evaluate a faculty development workshop on teaching about racism to facilitate curriculum development at home institutions. METHODS Following development of a curricular toolkit, a train-the-trainer workshop was delivered at the 2017 Society of Teachers of Family Medicine Annual Spring Conference. Preconference evaluation and a needs assessment collected demographic data of participants, their learning communities, and experience in teaching about racism. Post-conference evaluations were completed at 2- and 6-month intervals querying participants' experiences with teaching about racism, including barriers; commitment to change expressed at the workshop; and development of the workshop-delivered curriculum. We analyzed quantitative data using Statistical Package for the Social Sciences (SPSS) software and qualitative data, through open thematic coding and content analysis. RESULTS Forty-nine people consented to participate. The needs assessment revealed anxiety but also an interest in obtaining skills to teach about racism. The most reported barriers to developing curriculum were institutional and educator related. The majority of respondents at 2 months (61%, n=14/23) and 6 months (70%, n=14/20) had used the toolkit. Respondents ranked all 10 components as useful. The three highest-ranked components were (1) definitions and developing common language; (2) facilitation training, exploring implicit bias, privilege, intersectionality and microaggressions, and videos/podcasts; and (3) Theater of the Oppressed and articles/books. CONCLUSIONS Faculty development training, such as this day-long workshop and accompanying toolkit, can advance skills and increase confidence in teaching about racism.
Differences in the use of telephone and video telemedicine visits during the COVID-19 pandemic.

OBJECTIVES The coronavirus disease 2019 (COVID-19) pandemic forced health systems to offer video and telephone visits as in-person visit alternatives. Although video visits offer some benefits compared with telephone visits, they require complex setup, which may disadvantage some patients due to the "digital divide. " Our objective was to determine patient and neighborhood characteristics associated with visit modality. STUDY DESIGN This was a cross-sectional study across 1652 primary care and specialty care practices of adult patients at an integrated health system from April 23 to June 1, 2020. METHODS We used electronic health record and administrative data. Our primary outcome was visit modality (in-person, video, or telephone), which was captured using billing codes. We assessed predictors of using video vs telephone using multivariable logistic regression. We used hierarchical logistic regression to determine the contribution of patient-, physician-, and practice-level components of variance in the choice of video or telephone visits. RESULTS We analyzed 231,596 visits by 162,102 patients. Sixty-five percent of the visits were virtual (31.7% telephone, 33.5% video). Patients who were older than 65 years (adjusted odds ratio [AOR], 0.41; 95% CI, 0.40-0.43), Black (AOR, 0.60; 95% CI, 0.57-0.63), Hispanic (AOR, 0.76; 95% CI, 0.73-0.80), Spanish-speaking (AOR, 0.57; 95% CI, 0.52-0.61), and from areas with low broadband access (AOR, 0.93; 95% CI, 0.88-0.98) were less likely to use video visits. Practices (38%) and clinicians (26%) drove more of the variation in video visit use than patients (9%). CONCLUSIONS Telemedicine access differences may compound disparities in chronic disease and COVID-19 outcomes. Institutions should monitor video visit use across demographics and equip patients, clinicians, and practices to promote telemedicine equity.
Osmosis in semi-permeable pores: an examination of the basic flow equations based on an experimental and molecular dynamics study

Classically ‘semi-permeable’ pores are generally considered to mediate osmotic flow at a rate dependent upon the hydraulic conductance of the pore and the difference in water potential. The shape or size of the solute molecules is not considered to exert a first-order effect on the flow rate nor is the hydraulic conductance thought to be solute dependent. By the experimental measurement of osmosis in the biological pore AQP (aquaporin) and hard-sphere molecular dynamics simulation of a model pore, we show here that the solute radius can have a profound effect on the osmotic flow rate, causing it to decline steeply with decreasing solute radius. Using a simple non-equilibrium thermodynamic theory, we propose that an additional ‘osmotic flow coefficient’ is required to describe flows in semi-permeable structures such as AQPs, and that the fall in flow rate with radius represents a conversion from hydraulic to diffusive water flow due to increasing penetration of the pore by the solute. The interaction between the pore geometry and the solute size cannot, therefore, be overlooked, although for every solute the system obeys the criterion for semi-permeability required by basic thermodynamics. The osmotic pore theory therefore reveals a novel and potentially rich structure that remains to be explored in full.
Exercise reduced the formation of new adipocytes in the adipose tissue of mice in vivo

Exercise has beneficial effects on metabolism and health. Although the skeletal muscle has been a primary focus, exercise also mediates robust adaptations in white adipose tissue. To determine if exercise affects in vivo adipocyte formation, fifty-two, sixteen-week-old C57BL/6J mice were allowed access to unlocked running wheels [Exercise (EX) group; n = 13 males, n = 13 females] or to locked wheels [Sedentary (SED) group; n = 13 males, n = 13 females] for 4-weeks. In vivo adipocyte formation was assessed by the incorporation of deuterium (2H) into the DNA of newly formed adipocytes in the inguinal and gonadal adipose depots. A two-way ANOVA revealed that exercise significantly decreased new adipocyte formation in the adipose tissue of mice in the EX group relative to the SED group (activity effect; P = 0.02). This reduction was observed in male and female mice (activity effect; P = 0.03). Independent analysis of the depots showed a significant reduction in adipocyte formation in the inguinal (P = 0.05) but not in the gonadal (P = 0.18) of the EX group. We report for the first time that exercise significantly reduced in vivo adipocyte formation in the adipose tissue of EX mice using a physiologic metabolic 2H2O-labeling protocol.
Effects of Objective and Subjective Health Literacy on Patients’ Accurate Judgment of Health Information and Decision-Making Ability: Survey Study

Background Interpreting health information and acquiring health knowledge have become more important with the accumulation of scientific medical knowledge and ideals of patient autonomy. Health literacy and its tremendous success as a concept can be considered an admission that not all is well in the distribution of health knowledge. The internet makes health information much more easily accessible than ever, but it introduces its own problems, of which health disinformation is a major one. Objective The objective of this study was to determine whether objective and subjective health literacy are independent concepts and to test which of the two was associated more strongly with accurate judgments of the quality of a medical website and with behavioral intentions beneficial to health. Methods A survey on depression and its treatments was conducted online (n=362). The Newest Vital Sign was employed to measure objective, performance-based health literacy, and the eHealth Literacy Scale was used to measure subjective, perception-based health literacy. Correlations, comparisons of means, linear and binary logistic regression, and mediation models were used to determine the associations. Results Objective and subjective health literacy were weakly associated with one another (r=0.06, P=.24). High objective health literacy levels were associated with an inclination to behave in ways that are beneficial to one’s own or others’ health (Exp[B]=2.068, P=.004) and an ability to recognize low-quality online sources of health information (β=–.4698, P=.005). The recognition also improved participants’ choice of treatment (β=–.3345, P<.001). Objective health literacy helped people to recognize misinformation on health websites and improved their judgment on their treatment for depression. Conclusions Self-reported, perception-based health literacy should be treated as a separate concept from objective, performance-based health literacy. Only objective health literacy appears to have the potential to prevent people from becoming victims of health disinformation.