Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient Perspectives on Innovative Telemonitoring Enhanced Care Program for Chronic Heart Failure (ITEC-CHF): Usability Study

Background Telemonitoring enables care providers to remotely support outpatients in self-managing chronic heart failure (CHF), but little is known about the usability and patients’ willingness to engage with this technology. Objective This study aims to evaluate feedback from patients with CHF following participation in the Innovative Telemonitoring Enhanced Care program for CHF (ITEC-CHF) study. Methods The telemonitoring intervention consisted of three components: remote weight monitoring, structured telephone support, and nurse-led collaborative care. Participants were provided with electronic weighing scales (W550; ForaCare), and a computer tablet (Galaxy Tab A; Samsung). They were asked to weigh themselves on the provided scales daily. Telemonitoring was integrated with a personal assistance call service and a nurse care service according to their workflows in usual care. Feedback on the usability of ITEC-CHF was collected via survey from study participants following 6 months of receiving telemonitoring care for their body weight. Survey responses were provided on a 5-point Likert scale and through open-ended questions to determine participants’ perceived benefits and barriers to using ITEC-CHF. Results A total of 67 participants (49/67, 73% male), with a mean age of 69.8 (SD 12.4) years completed the survey. The majority of participants agreed or strongly agreed that the ITEC-CHF program was easy to use (61/67, 91%), easy to navigate (51/65, 78%), useful (59/65, 91%), and made them feel more confident in managing their weight (57/67, 85%). Themes related to participants’ perceptions of telemonitoring included increased support for early intervention of clinical deterioration, improved compliance to daily weighing, a sense of reassurance, and improved self-care and accountability, among others. Conclusions ITEC-CHF was rated highly on usability and was well accepted by users as part of their routine self-management activities. Participants were willing to use telemonitoring because they perceived a broad spectrum of benefits for CHF management. Trial Registration Australian New Zealand Clinical Trial Registry ID ACTRN 12614000916640; https://www.anzctr. org.au/Trial/Registration/TrialReview.aspx? id=366691.
Characterization of Integrons and Quinolone Resistance in Clinical Escherichia coli Isolates in Mansoura City, Egypt

Escherichia coli is a common pathogen in both humans and animals. Quinolones are used to treat infections caused by Gram-negative bacteria, but resistance genes emerged. Only scarce studies investigated the association between plasmid-mediated quinolone resistance (PMQR) genes and integrons in clinical isolates of E. coli. The current study investigated the prevalence of quinolone resistance and integrons among 134 clinical E. coli isolates. Eighty (59.70%) isolates were quinolone-resistant, and 60/134 (44.77%) isolates were integron positive with the predominance of class I integrons (98.33%). There was a significant association between quinolone resistance and the presence of integrons (P < 0.0001). Isolates from Urology and Nephrology Center and Gastroenterology Hospital were significantly quinolone-resistant and integron positive (P ≤ 0.0005). Detection of PMQR genes on plasmids of integron-positive isolates showed that the active efflux pump genes oqxAB and qepA had the highest prevalence (72.22%), followed by the aminoglycoside acetyltransferase gene (aac(6′)-Ib-cr, 66.67%) and the quinolone resistance genes (qnr, 61.11%). Amplification and sequencing of integrons' variable regions illustrated that no quinolone resistance genes were detected, and the most predominant gene cassettes were for trimethoprim and aminoglycoside resistance including dfrA17, dfrB4, and dfrA17-aadA5. In conclusion, this study reported the high prevalence of PMQR genes and integrons among clinical E. coli isolates. Although PMQR genes are not cassette-born, they were associated with integrons' presence, which contributes to the widespread of quinolone resistance in Egypt.
Arginase 1–Based Immune Modulatory Vaccines Induce Anticancer Immunity and Synergize with Anti–PD-1 Checkpoint Blockade

ARG1-targeting vaccines are shown to activate antitumor immunity and modulate the tumor microenvironment in multiple tumor models without causing toxicity. The anti-tumor effect of ARG1 vaccines was boosted by anti–PD-1 checkpoint blockade, highlighting potential use as an immunotherapy. Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity of ARG1 promotes the formation of an immunosuppressive microenvironment and leads to a more aggressive phenotype in many cancers. Intrinsic T-cell immunity against ARG1-derived epitopes in the peripheral blood of cancer patients and healthy subjects has previously been demonstrated. To evaluate the antitumor efficacy of ARG1-derived peptide vaccines as a monotherapy and as a combinational therapy with checkpoint blockade, different in vivo syngeneic mouse tumor models were utilized. To evaluate the antitumor effects, flow cytometry analysis and IHC were performed on tumors, and ELISPOT assays were performed to characterize immune responses. We show that ARG1-targeting therapeutic vaccines were able to activate endogenous antitumor immunity in several in vivo syngeneic mouse tumor models and to modulate the cell composition of the tumor microenvironment without causing any associated side effects or systemic toxicity. ARG1-targeting vaccines in combination with anti–PD-1 also resulted in increased T-cell infiltration, decreased ARG1 expression, reduced suppressive function of tumor-educated myeloid cells, and a shift in the M1/M2 ratio of tumor-infiltrating macrophages. These results indicated that the induced shift toward a more proinflammatory microenvironment by ARG1-targeting immunotherapy favors effective tumor control when combined with anti–PD-1 checkpoint blockade. Our data illustrate the ability of ARG1-based immune modulatory vaccination to elicit antigen-specific immunosurveillance and imply the feasibility of this novel immunotherapeutic approach for clinical translation.
Prenatal care providers’ perceptions of the SARS-Cov-2 vaccine for themselves and for pregnant women

Background Prenatal care providers will play an important role in the acceptance of SARS-Cov-2 vaccination for pregnant women. Objective To determine the perceptions of French prenatal care providers: midwives, general practitioners (GPs) and obstetricians and gynaecologists (Ob-Gyn) regarding SARS-CoV-2 vaccination during pregnancy. Study design An anonymous online survey was sent to members of French professional societies representing prenatal practitioners. The participants were asked to answer questions on their characteristics and give their opinions of the SARS-CoV-2 vaccine for themselves and women who are pregnant or willing to become pregnant. Results Access to the survey was opened from January 11th, 2021, to March 1st, 2021. A total of 1,416 responses were collected from 749 Ob-Gyn, 598 midwives and 69 GPs. Most respondents (86.7% overall, 90.4% for Ob-GYN, 81.1% for GPs and 80.1% for midwives) agreed to receive the SARS-CoV-2 vaccine. Vaccination against SARS-CoV-2 would be offered to pregnant women by 49.4% 95%CI [48.1–50.8] of the participants. Midwives were less likely to recommend vaccination than GP and Ob-Gyn (37.5%, 50.7% and 58.8%, respectively). The multinomial logistic regression revealed that being an obstetrician, working in a group, usually offering a flu vaccine and wanting to be vaccinated against SARS-CoV-2 were positively associated with considering pregnant women for SARS-CoV-2 vaccination. Conclusion Most French prenatal healthcare providers are favourable towards vaccinating pregnant women, but a large minority express reservation. More evidence on safety and involvement by professional organisations will be important to encourage the access of pregnant women to vaccination against SARS-CoV-2.
Prognostic value of signs and symptoms in heart failure patients using remote telemonitoring

Introduction Heart failure is a serious burden on health care systems due to frequent hospital admissions. Early recognition of outpatients at risk for clinical deterioration could prevent hospitalization. Still, the role of signs and symptoms in monitoring heart failure patients is not clear. The heart failure coach is a web-based telemonitoring application consisting of a 9-item questionnaire assessment of heart failure signs and symptoms and developed to identify outpatients at risk for clinical deterioration. If deterioration was suspected, patients were contacted by a heart failure nurse for further evaluation. Methods Heart failure coach questionnaires completed between 2015 and 2018 were collected from 287 patients, completing 18,176 questionnaires. Adverse events were defined as all-cause mortality, heart failure- or cardiac-related hospital admission or emergency cardiac care visits within 30 days after completion of each questionnaire. Multilevel logistic regression analyses were performed to assess the association between the heart failure coach questionnaire items and the odds of an adverse event. Results No association between dyspnea and adverse events was observed (odds ratio 1.02, 95% confidence interval 0.79–1.30). Peripheral edema (odds ratio 2.21, 95% confidence interval 1.58–3.11), persistent chest pain (odds 2.06, 95% confidence interval 1.19–3.58), anxiety about heart failure (odds ratio 2.12, 95% confidence interval 1.44–3.13), and extensive struggle to perform daily activities (odds ratio 2.23, 95% confidence interval 1.38–3.62) were significantly associated with adverse outcome. Discussion Regular assessment of more than the classical signs and symptoms may be helpful to identify heart failure patients at risk for clinical deterioration and should be an integrated part of heart failure telemonitoring programs.
Public knowledge, attitudes and practices related to antibiotic use and resistance in Singapore: a cross-sectional population survey

Objectives The WHO’s Global Action Plan on Antimicrobial Resistance (AMR) includes increasing overall public awareness of appropriate antibiotic use and resistance as a key priority area. We aimed to measure public knowledge, attitudes and practices of antibiotics and antibiotic resistance in Singapore, as well as their healthcare-seeking behaviours relating to respiratory illnesses, providing baseline data against which to measure the progress of future interventions. Design A cross-sectional study. Setting The general population in Singapore. Participants Between May and June 2019, we conducted a survey via an online panel in Singapore with 706 respondents. Results Our findings indicated common misconceptions surrounding antibiotic effectiveness and mechanisms of antibiotic resistance—most participants thought that resistance occurs when our bodies become resistant to antibiotics (62.5%) or when antibiotics become less powerful (48.5%). In multivariable analyses, better knowledge scores were associated with more favourable antibiotic attitudes (β=0.29; 95% CI 0.20 to 0.37). In addition, more favourable attitude scores were associated with lower odds of both expecting (OR: 0.84, 95% CI 0.72 to 0.99) and being prescribed antibiotics by a primary care doctor (OR: 0.76, 95% CI 0.63 to 0.90). Conclusions This study presents important information about population perceptions towards antibiotics and antibiotic resistance in Singapore. Results from this study emphasise the importance of effective public communication strategies to promote responsible antibiotic use locally and should be used to inform future implementation of programmes and activities as laid out in Singapore’s National Strategic Action Plan on AMR.
A “Prime and Deploy” Strategy for Universal Influenza Vaccine Targeting Nucleoprotein Induces Lung-Resident Memory CD8 T cells

Lung-resident memory T cells (TRM) play an essential role in protecting against pulmonary virus infection. Parenteral administration of DNA vaccine is generally not sufficient to induce lung CD8 TRM cells. This study investigates whether intramuscularly administered DNA vaccine expressing the nucleoprotein (NP) induces lung TRM cells and protects against the influenza B virus. The results show that DNA vaccination poorly generates lung TRM cells and massive secondary effector CD8 T cells entering the lungs after challenge infection do not offer sufficient protection. Nonetheless, intranasal administration of non-replicating adenovirus vector expressing no Ag following priming DNA vaccination deploys NP-specific CD8 TRM cells in the lungs, which subsequently offers complete protection. This novel ‘prime and deploy’ strategy could be a promising regimen for a universal influenza vaccine targeting the conserved NP Ag.
High photodegradation and antibacterial activity of BN–Ag/TiO2 composite nanofibers under visible light

To develop material with good photocatalytic properties for organic compound degradation and bacterial removal, we produced Ag/TiO2 and BN–Ag/TiO2 composite nanofibers that included controlled amounts of boron nitride (BN) nanosheets and silver (Ag). After annealing at 500 °C under air, we used scanning electron microscopy, transmission electron microscopy, Brunauer–Emmet–Teller analysis, X-ray diffraction, energy-dispersive X-ray spectroscopy, Raman spectroscopy, UV-visible reflectance spectroscopy and room temperature photoluminescence to investigate the morphological, structural and optical properties of all samples. The photocatalytic tests using methylene blue under visible light, in repeated and long-term applications, showed that the photodegradation activity of BN(5 wt%)–Ag(3 wt%)/TiO2 composite nanofibers was 17.2 and 2.3 times higher than that of pure TiO2 and Ag(3 wt%)/TiO2 nanofibers, respectively. In antibacterial tests using Gram-negative Escherichia coli, 3 hours of incubation with BN(5 wt%)–Ag(3 wt%)/TiO2 composite nanofibers killed all bacteria. These results indicate that the synthesized BN(5 wt%)–Ag(3 wt%)/TiO2 composite nanofibers can be considered to be a multifunctional material for photodegradation and antibacterial applications.
Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect

Abstract Context Rosmarinic acid (RA) dose-dependently ameliorates acetaminophen (APAP) induced hepatotoxicity in rats. However, whether RA hepatoprotective effect is by regulating RACK1 and its downstream signals is still unclear. Objective This study explores the RA protective effect on APAP-induced ALI and its mechanism. Materials and methods Sixty Kunming mice 6–8 weeks old were randomly separated into six groups (n = 10) and pre-treated with normal saline, ammonium glycyrrhetate (AG) or RA (10, 20 or 40 mg/kg i.p./day) for two consecutive weeks. Then, APAP (300 mg/kg, i.g.) was administrated to induce ALI, except for the control. Serum alanine/aspartate aminotransferases (ALT and AST), malondialdehyde (MDA), superoxide dismutase (SOD) and histopathology were used to authenticate RA effect. The liver RACK1 and TNF-α were measured by western blot. Results Compared with the APAP group, different dosages RA significantly decreased ALT (52.09 ± 7.98, 55.13 ± 10.19, 65.08 ± 27.61 U/L, p < 0.05), AST (114.78 ± 19.87, 115.29 ± 31.91, 101.78 ± 21.85 U/L, p < 0.05), MDA (2.37 ± 0.87, 2.13 ± 0.87, 1.86 ± 0.39 nmol/mg, p < 0.01) and increased SOD (306.178 ± 90.80, 459.21 ± 58.54, 444.01 ± 78.09 U/mg, p < 0.05). With increasing doses of RA, RACK1 and TNF-α expression decreased. Moreover, the RACK1 and TNF-α levels were positively correlated with MDA (r = 0.8453 and r = 0.9391, p < 0.01). Discussion and conclusions Our findings support RA as a hepatoprotective agent to improve APAP-induced ALI and the antioxidant effect mediated through RACK1/TNF-α pathway.
Abelacimab and factor XI inhibition: a novel mechanism for the prevention of venous thromboembolism.

FXI, a relatively novel target for thromboprophylaxis, appears to play a major role in pathological thrombosis, with limited role in physiological haemostasis. Recent evidence suggests that inhibiting factors of the contact system, such as FXI and its activated form (FXIa), may effectively prevent pathological thrombosis without increasing bleeding risk. Particular interest in the contact system of coagulation comes from epidemiological studies showing that patients with congenital FXI deficiency are at lower risk for VTE and stroke, but not at increased risk of serious bleeding. In addition, studies in animals with antibodies directed against FXI and antisense oligonucleotide blocking FXI biosynthesis demonstrated that these agents may reduce thrombosis. FXIdirected strategies include inhibitors of biosynthesis, antibodies (such as abelacimab), small molecules, and derivatives of naturally occurring inhibitors. Key Points
Mean Field Games Systems under Displacement Monotonicity

In this note we prove the uniqueness of solutions to a class of Mean Field Games systems subject to possibly degenerate individual noise. Our results hold true for arbitrary long time horizons and for general non-separable Hamiltonians that satisfy a so-called $displacement\ monotonicity$ condition. This monotonicity condition that we propose for non-separable Hamiltonians is sharper and more general than the one proposed in our earlier work written jointly with Gangbo and Zhang. The displacement monotonicity assumptions imposed on the data provide actually not only uniqueness, but also the existence and regularity of the solutions. Our analysis uses elementary arguments and does not rely on the well-posedness of the corresponding master equations.
Hydrodynamic attractor in the nonconformal Bjorken flow

Non-conformal attractor behavior is studied by solving non-conformal second order viscous hydrodynamics with respect to boost-invariant plasmas. Numerical solutions of the relative decay rate of the enthalpy density, the inverse shear and bulk Reynolds numbers, all exhibit universal patterns towards an ideal fluid description at late stages, demonstrating the existence of non-conformal hydrodynamic attractor. However, as a generic feature, the non-conformal hydrodynamic attractor emerges only at late times, which differs drastically from the behavior observed in conformal systems. The absence of the early-time attractor in non-conformal fluids is a consequence of the early-time instable mode, which arises from a positive-valued eigen-mode associated with the freestreaming dynamics. To support practical simulations of hydrodynamics in high-energy heavy-ion collisions, early-time attractor can be restored in a mixture of the shear and the bulk viscous corrections, in which early-time instable modes cancel approximately. Early-time non-conformal attractor is also approachable, if the quadratic coupling between the bulk pressure and the expansion rate is enhanced by at least a factor of two through the transport coefficient δΠΠ. ∗ cliyan@fudan.edu. cn 1 ar X iv :2 10 9. 06 65 8v 1 [ nu cl -t h] 1 4 Se p 20 21
Clinical Utility of Circulating Tumor Cells in the Early Detection of Lung Cancer in Patients with a Solitary Pulmonary Nodule

Objective: Lung cancer is the most common cancer and can appear as a solitary pulmonary nodule. Early detection of lung cancer in this patient population would be beneficial for the disease management. In this study, the potential application of circulating tumor cells (CTCs) on early detection of lung cancer in this population was investigated. Methods: The number of CTCs in bronchoalveolar lavage fluid and serum levels of tumor-related markers, cancer antigen 125 (CA125), carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) were measured in patients with a solitary pulmonary nodule. The association between CTCs and lung cancer was examined. The diagnosis performances of CTCs and selected tumor-related markers were compared. Results: The CTC positivity was significantly associated with lung cancer (P = .009). The sensitivity of CTCs and CA125, CEA, NSE, and CA125/CEA/NSE was 75%, 5.6%, 0%, 25%, and 33%, respectively. The sensitivity of CTCs was improved from 75% to 83% by the combination with CA125 or NSE. Conclusion: CTCs may be helpful for the early detection of lung cancer in patients with a solitary pulmonary nodule.
The Evolving Interstellar Medium of Star-forming Galaxies, as Traced by Stardust

We analyze the far-infrared (FIR) properties of ∼5000 star-forming galaxies at z < 4.5, drawn from the deepest, super-deblended catalogs in the GOODS-N and COSMOS fields. We develop a novel panchromatic spectral energy distribution fitting algorithm, Stardust, that models the emission from stars, active galactic nuclei (AGNs), and infrared dust emission, without relying on energy balance assumptions. Our code provides robust estimates of the UV−optical and FIR physical parameters, such as the stellar mass (M *), dust mass (M dust), infrared luminosities (L IR) arising from AGN and star formation activity, and the average intensity of the interstellar radiation field (〈U〉). Through a set of simulations we quantify the completeness of our data in terms of M dust, L IR, and 〈U〉 and subsequently characterize the distribution and evolution of these parameters with redshift. We focus on the dust-to-stellar mass ratio (f dust), which we parameterize as a function of cosmic age, stellar mass, and specific star formation rate. The f dust is found to increase by a factor of 10 from z = 0 to z = 2 and appears to remain flat at higher z, mirroring the evolution of the gas fraction. We also find a growing fraction of warm to cold dust with increasing distance from the main sequence, indicative of more intense interstellar radiation fields, higher star formation efficiencies, and more compact star-forming regions for starburst galaxies. Finally, we construct the dust mass functions (DMFs) of star-forming galaxies up to z = 1 by transforming the stellar mass function to DMF through the scaling relations derived here. The evolution of f dust and the recovered DMFs are in good agreement with the theoretical predictions of the Horizon-AGN and IllustrisTNG simulations.
A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults.

INTRODUCTION Brucellosis is a zoonosis with a wide spectrum of clinical manifestations. However, it is still unclear whether the clinical manifestations in children are significantly different from those in adults. METHODOLOGY Patients with brucellosis and treated at the General Hospital of Ningxia Medical University between 2009 and 2019 were divided into two groups; children (88) and adults (354). Thereafter, the records of the two groups were analyzed retrospectively. RESULTS The findings showed that: 1. School-age children, young and middle-aged individuals were more likely to suffer from brucellosis and most were male; 2. Fever and arthralgia were the most common manifestations in the two groups. In addition, fatigue and low back pain were rare in children although fever and lymphadenopathy were more common in this group. However, hepatomegaly and splenomegaly were common in both groups; 3. The most common complication was osteoarthritis and peripheral arthritis occurred more frequently in children. On the other hand, spondylitis was the most common in adults (this particularly involved the lumbar and sacral vertebrae); 4. An increase in the erythrocyte sedimentation rate, levels of the C-reactive protein and liver enzymes was common in both two groups; 5. There was no significant difference in the positive rate of the standard agglutination test between children (96.59%) and adults (95.20%). However, the positive rate of blood culture was higher in children (65.85%) than in adults (51.00%). CONCLUSIONS Brucellosis causes damage to multiple systems and differences in clinical characteristics were found between children and adults.