Miracle-dz/UniFAR-FTUs huggingface dataset:
AN5_OA_Abu Nadeem

Background: Norepinephrine is the first-line vasopressor in the management of severe sepsis. Epinephrine may be added or act as a substitute. Aims: To evaluate the efficacy of epinephrine in management of severe sepsis. Settings and Design: Intensive Care Unit, randomised controlled prospective study. Methods: 50 adult patients of both sexes suffering from severe sepsis and septic shock were studied. The patients were randomized into two groups each comprising of 25 patients. Group A patients were treated with norepinephrine and Group B patients with epinephrine. The patients were managed based on the early goal-directed therapy of sepsis management. After the first 6 hours of therapy the study drugs were compared on the basis of Pulse rate, CVP, MAP, ScvO2, SOFA score, time taken to achieve target MAP and the LOS in ICU. Statistical analysis used: Mean (SD), Unpaired and Paired ‘t’ test Results: The pulse rate decreased significantly in Group A whereas it increased significantly in Group B (p < 0.01). The two groups showed statistically significant increment in CVP, MAP and ScvO2 after 6 hours of treatment. The decrease in SOFA score in both the groups was statistically significant (p < 0.001). The total intake and output of fluids (ml), length of ICU stay (LOS) and the time taken to achieve the target MAP were comparable between the two groups. Conclusion : Epinephrine is as effective as norepinephrine in the management of severe sepsis and septic shock. The beneficial aspect of epinephrine outweighs its adverse effects. It should be considered as a first-line drug especially in underdeveloped countries.
Contextual and Environmental Health Protection and Risk Factors that are not taken into Consideration in the Routine Medical Consultation

Medicine tends to be a holistic discipline, according to which the individual should be treated as a whole and provide comprehensive biopsychosocial health care and also in relation to the environment. The effects of climate change on the disease burden require the doctor to make a "situation diagnosis": that is, to get an idea of the interaction of man with his context. From the general medical care level there are a number of possibilities of including the environmental nuance in clinical tasks with patients, which have protective and health promoting effects, individually and with global ecological repercussions: 1) The therapeutic contexts (those places, situations or contexts that achieve both physical and psychic environments associated with an improvement of health or well-being): the healing power of the environment and nature (green spaces, forests, parks, open spaces, and gardens personal, walking-for-thinking, living with a companion animal); 2) To be aware of the ecological repercussions of the “micro” decisions: Ecological and environmental effects of the prescription of certain drugs, of the dietary advice, preventive approaches for patients in the consultation that are based on environmental measures (as in osteoporosis, prevention of skin cancer, etc. 3) Promote the human factor: contextual circumstances in the relationship which can condition listening, and therefore, diagnosis and intervention; 4) Change the perception of the environment: mental landscapes, through artistic creation, etc and 5) Pharmaceutical contamination of nature, secondary to polypharmacy and therapeutic non-compliance: generalized contamination of river systems worldwide with antibiotic compounds, pharmaceutical contamination at sea, drug contamination is concentrated in insects and passes to the Predators. In short, in general medicine, tasks carried out at a small caliber level can subtly tilt the world towards ecology, dignity, compassion, and health.
Screening of Gastric Antiulcer Activity of Sida

Ulcers were introduced in 36 hrs fasted albino rats of either sex by aspirin plus pylorus ligation, aspirin, and ethanol treatment. Each induction model had four groups namely control, test and standard. In each model of ulcer induction, group that was predosed with the ethanolic extract of leaves of Sida acuta showed a considerable degree of antiulcer activity in comparison to positive controlled treated group. The antiulcer activity was appraised by determining and comparing the ulcer index in the test drug groups with that of the control group as well as Famotidine (20mg/kg) was used as reference drug. The results revealed significant antiulcer activity by reducing the ulcer index in the above model. The results obtained were verified with one way ANOVA followed by Scheff’s (multiple range test) and found to be significant at (p<0.001).
HR Leadership and Cohesion of Continuous Improvement: The Case of a Sri Lankan Garment Factory

Achieving cohesive function of an organization for its continuous improvement is one major challenge faced by its management today. Under this debate, many researchers have emphasized the uniformity of organization and its cohesive function than its divisive potential. Subgroups with different educational, ethnic, gender and other divisive potential have limited the cohesive function of organization towards its continuous improvement to a greater extent. By using the multidimensional perspective of cohesion towards continuous improvement and adopting the case study research strategy, multiple data gathering methods, and qualitative data analysis, this paper tried to examine the research issue mentioned above pertaining to a popular Sri Lankan garment factory which has won several continuous improvement oriented business awards. The paper reveals that the human resource leadership (HR leadership) of the organization has played the initiative role in making its different work groups (i.e., associates, staff, executives, assistant managers, and managers) cohesive, which substantially contributed to its continuous improvement over time.
Interleukin-1β-511 and interleukin-6 gene polymorphisms in Egyptian children with febrile seizures

Purpose: to determine whether interleukin-1β-511 promoter polymorphism (IL-1β-511 C/T) and Interleukin-6 gene polymorphism (_597) (IL-6), contribute to the susceptibility of Febrile Seizures (FS). Method: A case-control study was conducted on 91 children. It included 49 patients with FS and 42 healthy control subjects. They were subjected to full medical history, general and neurological examination and E.E.G. IL-1β (_511) polymorphism and IL-6 (_597) polymorphism genotyping by RFLP (Restriction fragment length polymorphism) were done for all participants. Results: Twenty-six patients (53.1%) had complex FS. IL-1β (_511) gene polymorphism and IL-6 (_597) gene polymorphism were more statistically significant in FS. IL-1β (_511) gene polymorphism was more sensitive specific and accurate in FS than IL-6 (_597) gene polymorphism. Conclusions: Our data support the contention that interleukin-6 and Interleukin-1β single-nucleotide polymorphisms play a role in the etiopathogenesis of febrile seizures. Neither Interleukin-1β (_511) gene polymorphism nor interleukin-6 (_597) gene polymorphism is affected by type of FS (whether simple or complex). [Hadeer Mahmoud Abdel Ghaffar; Hanaa Hassan El Dash; Shahira Morsi El Shafie; Nashwa Mamdouh Samra, Huda Ahmed Yossif Mohammed; Noha Khalifa Abdel Ghaffar. Interleukin-1β-511 and interleukin-6 gene polymorphisms in Egyptian children with febrile seizures. J Am Sci 2019;15(10):92-97]. ISSN 1545-1003 (print); ISSN 2375-7264 (online). http://www.jofamericanscience. org. 12. doi:10.7537/marsjas151019.12.
The Role of Magnetic Resonance Imaging in Predicting Surgical Outcome in Patients with Degenerative Cervical Myelopathy

Magnetic resonance imaging (MRI) is commonly used to confirm a diagnosis of degenerative cervical myelopathy (DCM), however, its role in predicting outcome following surgical treatment remains unclear. Herein, it is hypothesized that quantitative preoperative MRI analysis can predict surgical outcome. Using data derived from a prospective and multicenter cohort of patients undergoing surgical treatment for DCM, multiple MRI parameters were assessed, including presence/absence of signal change on T1 and T2, T2 signal quantitative factors, and anatomical measurements. A dichotomized postoperative modified Japanese orthopedic association score at 6‐months was then used to characterize patients with mild myelopathy (≥16) and those with substantial residual neurological impairment (<16). Using multivariate logistic regression analysis, the results indicate that assessment of maximum canal compromise, T1 signal change and baseline functional severity provide superior prognostic value than baseline functional severity alone. It is therefore concluded that MRI has a statistically significant role in predicting surgical outcome.
A Computational Model of Mitochondrial Beta-Oxidation Highlighting the Implications on Uremia Disease in Human

Enzyme deficiencies can segment the metabolic reactions in the mitochondrion and may spark to augmentation of specific substrates causing severe clinical manifestations. During the state of starvation mitochondrial oxidation of long-chain fatty acids procures a vital source of energy for the heart as well as for skeletal muscle. A computational kinetic network of reactions, compounds and parameters was constructed to correlate the mitochondrial fatty acid beta-oxidation to disease conditions. Carnitine deficiency limits the availability of the long chain acyl-CoAs inside the mitochondrial matrix. Majorly, carnitine is necessary for fatty acid transport to sites of beta-oxidation in the mitochondria. An increased ratio of long-chain acyl-carnitine (LCAC) to free carnitine, was observed when carnitine level was declined. This verifies that uremic patients have altered carnitine metabolism. Subjecting the constructed model of the biochemical reactions involved in fatty acid catabolism to further simulations at varying concentrations will provide predictive models to identify the disease targets.
The identification of novel tumour-specific transcripts in pancreatic carcinoma using differential display

Pancreatic carcinoma constitutes the fifth most frequent cause of cancer death in the Western world. Due to the aggressiveness of the disease, conventional forms of therapy are poor, and therefore, there is a need for more effective forms of therapy. A gene therapy approach to cancer using GPAT (Genetic Prodrug Activation Therapy) has been described which exploits the transcriptional regulatory elements of a gene expressed in a tumourspecific manner to direct the expression of a prodrug activating enzyme specifically in tumour cells, and therefore, provides a novel treatment strategy for pancreatic carcinoma. The aim of this work was to use the technique of differential display (DD) to identify genes whose expression is significantly upregulated in pancreatic carcinoma and to identify those which are transcriptionally upregulated and have an expression profile most compatible with GPAT strategies. Such gene(s) could provide gene regulatory elements that could be employed in GPAT for pancreatic cancer. DD was established and used successfully to isolate five transcripts specifically upregulated in pancreatic tumour cell lines compared to normal cells; Band 2, Band 3, Band 5 (Lplastin), Band 7 (tissue factor) and Band 26 (ELP-1). Through analyses of these five fragments, tissue factor (TF) was found to have the most suitable profile in view of a gene whose regulatory elements could be used in GPAT and is transcriptionally upregulated 510 fold in tumour cells. Studies investigating the transcriptional control of TF in pancreatic tumour cell lines revealed that important regulatory elements mediating TF overexpression did not reside in the proximal promoter. A DNase I hypersensitive site (HS) was identified in the second intron of the TF gene specifically in tumour cell lines overexpressing TF. However, restriction fragments spanning this DNase I HS did not exhibit classical enhancer activity. In addition, other studies showed that important regulatory elements did not lie within regions of the TF gene cloned to date. Further work is therefore required to determine the potential use of TF in a GPAT approach to pancreatic cancer.
Percutaneous Ultrasound Tenotomy using the Tenex System on the Adductor Longus Tendon: A Pilot Case Series

Groin pain caused by tendinopathy is a significant problem in athletic populations; an accurate and effective treatment is required for minimal turnaround time for athletes. Ultrasound guided percutaneous tenotomy of the adductor longus tendon may be a good treatment option for patients who have failed conservative treatment. The procedure has a quick recovery time with no complications and patients report good relief after this procedure.
COMPREHENSIVE STUDY OF EICHHORNIA CRASSIPES FOR AMINO ACID PROFILING AND NUTRITIONAL ASSESSMENT

Eichhornia crassipes (water hyacinth) listed as one of the most productive plants on earth and is considered as the world’s worst aquatic weed. It is a severe environmental and economic problem in all of the gulf coast states and in many other areas of the world with a subtropical or tropical climate. Inspite of these, as per our present study we can say “the world’s worst aquatic plant as a best dietary supplement and therapeutic pool’. Understanding the amino acids as basic structural and functional units of proteins, and have immense importance in nutrition, taxonomy and pharmacology; screening of amino acids from different extracts of Eichhornia crassipes was done in our research work. Assessment of chromatograms developed in thin layer chromatography (TLC) showed a total of eleven amino acids in water hyacinth (shoot and rhizome). Phytochemical screening revealed the presence of seven essential amino acids and four non-essential amino acids. The detected amino acids from plant were serine, valine, leucine, mehionine, aspartic acid, glutamic acid, lysine, tyrosine, tryptophan, histidine and isoleucine respectively. Present work was also designed to evaluate the nutritional potential of Eichhornia crassipes collected from the water bodies in Bilaspur. Results showed that plant was characterized by high fibre, high protein content, low lipids and low carbohydrates. In addition the anti-nutritive substance (nitrate) level was also determined and found to be safe as feed. The vital study of amino acid spectrum is of great importance on its strategic food and medicinal significance.
Austin Biometrics and Biostatistics Catchment Area Analysis Using Generalized Additive Models

A catchment area is the geographic area and population from which a health service center draws patients. Defining a catchment area allows the service center to describe its primary patient population and assess how well it meets the needs of patients within the catchment area. A catchment area definition is required for cancer centers applying for NCI-designated Cancer Center status. In this research, we estimated diagnosis catchment areas for the Massey Cancer Center (MCC) at Virginia Commonwealth University using a Generalized Additive Model (GAM) framework. We estimated diagnosis catchment areas for all cancers based on individual-level Virginia state cancer registry data. We used a GAM with a spatial smoother to model the residual log odds of being diagnosed with cancer at MCC after accounting for several covariates, including age, race, ethnicity, gender, and health insurance type. In addition, we used a Generalized Additive Mixed Model (GAMM) to account for multiple cancer diagnoses for the same patient. To define catchment areas, we identified the geographic areas with statistically significant residual log odds of being diagnosed for cancer at MCC. The diagnosis catchment area for MCC estimated from the GAM included 58 counties. Characteristics associated with increased odds of being diagnosed with cancer at MCC included black race, Hispanic ethnicity, younger age, no health insurance, and Medicaid health insurance. vs. 24.96%) and Hispanic (12.59% vs. 12.05%). Proportions of patients who were uninsured, self-pay or on Medicaid were higher in the MCC population living outside the catchment area. However, proportions of patients without health insurance or on Medicaid were greater outside the MCC catchment area than inside for both patients diagnosed at MCC and elsewhere.
PWIS: Personalized Web Image Search using One-Click Method

Personalized Web Image search is the one searching for the particular images of User intention on the Web. For searching images, a user might provide query terms like keyword, image file, or click on few image file, and therefore the system can determine the images similar to the query. The similarity used for search criteria could be Meta tags, color distribution in images, region/shapes attributes, etc. Web-scale image search engines namely Google and Bing searches for images are relying on the surrounding text features. It is highly cumbersome and complicated for the web-scale based image search engines to interpret users search intention only by querying of keywords. This leads to the incorporation of noise and high ambiguity in the search results which are extremely unfit in the context of the users. It's also a necessary mandate for using visual information for solving the problem of ambiguity in the text-based image retrieval scenario. In the case of Google search, search text box will auto complete while user is typing similar added keywords. This method will differ from user intention while searching. So to avoid this kind of faults, it is important to use visual information in order to solve the uncertainty in text-based image retrieval. To retrieve exact matching, and acquire user‟s intention we can allow them text query with extended or related images as a suggestion. We have proposed an innovative Web image search approach. It only needs the user to click on one query image with minimal effort and images from a pool fetched by text-based search are re-ranked based on both visual and textual contents.
ULTRASONOGRAPHIC EVALUATION OF FETAL HUMERUS LENGTH FOR ASSESSMENT OF GESTATIONALAGE AND ITS COMPARISON WITH OTHER CONVENTIONAL PARAMETERS

Introduction: Ultrasonography is being a painless, non-invasive, non-ionizing,portable, redoable and relatively inexpensive modality used to evaluate fetal growth parameter many times during pregnancy. Aim: To assess relationship between sonographic gestational age and fetal HUMERUS length between 16 and 39 weeks of gestation and to compare its accuracy with other biometric parameters. Materials and Methods: Prospective cross sectional study was performed on 500 normal singleton pregnancies at second and third trimesters between 16-39 weeks The study was conducted on a gray scale real-time ultrasound scanner using linear and sector transducers to measure the standard fetal biometrics and fetal humeral length. Results: Biparietal diameter (BPD), Head circumference (HC), Abdominal circumference (AC), and Femur length (FL) were compared with standard charts and scatter graphs were plotted. Coefficient of correlation were calculated which were for BPD, HC, AC, and FL, respectively, proving them reliable indicators. HL measured in the present study was compared with standard nomogram. A statistically significant curvilinear correlation was found between the HL and GA indicating it to be a reliable indicator of GA. Significant coefficient of correlation (0.16) was observed between HLand GAindicating it to be a reliable parameter. Conclusion: The HLwas most accurate parameter next to FLin assessing GA. The study also indicates that combination of BPD, HC, AC, FL, HL is more accurate in predicting GA than any single parameter, particularly in the third trimester of pregnancy. HL would contribute to maximum accuracy next to FLamongst all the parameters
Effects of Whole-Body Vibration and Resistance Training on Muscular Performance in Young Adults

Whole body vibration (WBV) training is rapidly gaining in popularity in health and fitness centers, as an alternative method to improve muscle performance. The aim of this study was to investigate the effects of 12 weeks program of WBV in combination with resistance training on muscular performance on healthy untrained adults. Subjects: A group of 40 young male adults; age 21.6 ±1.5 yrs were assigned into two equal groups: WBV group performed a WBV plus resistance training program (WBV + RES) and placebo group, performed the same resistance training program in absence of vibration (PL + RES). Methods: Participants were evaluated for anthropometry, isokinetic dynamometry and counter-movement jump (CMJ). After the intervention The data were collected and analyzed using a paired and un-paired t-test to compare the difference between the results within each group pre test and post test and between the two groups. Results: Significant differences (p<0.05) were observed in isometric strength, in both groups. There were significant differences between post test of WBV and placebo groups. Concerning CMJ, there was significant improvement in whole body vibration group only. Conclusion: The addition of WBV to resistance training for 12 weeks, in healthy untrained adults result in a larger muscular performance improvement compared to an identical exercise program in absence of vibration. So vibration exercise may be more effective and low time consuming tool to enhance muscular performance. [Moawd S, Abdelhalem N, Samhan A, Mahmoud WS. Effects of Whole-Body Vibration and Resistance Training on Muscular Performance in Young Adults. J Am Sci 2014;10(1):67-73]. (ISSN: 1545-1003). http://www.jofamericanscience. org. 14
GENETIC ANALYSIS OF SEED YIELD AND ITS COMPONENTS IN LINSEED (LINUM USITATISSIMUM L.) UNDER LATE SOWN CONDITIONS IN THE NORTH CENTRAL PLATEAU ZONE OF ODISHA IN INDIA

Five lines, three testers and their 15 F analysis of Kempthorne (1957) was employed to estimate additive genetic variance (σ genetic variance (σ standard heterosis (d branches per plant, number of capsules per plant, number of seeds per capsule,1000 and seed yield p gene action. Low estimates of H branches per plant and number of seeds per capsule which had negative heri OL 2capsules per plant and low d hybrids having significant positiv transgressive segregants which will increase the frequency of desirable genes for seed yield component traits
DBA AFRICA MANAGEMENT REVIEW

This study sought to determine how tacit knowledge interplays with organizational learning to enhance the competiveness of ICT content service providers in Nairobi. Many scholars, building on the resource-and knowledge-based theories of strategic management theory, have postulated that tacit knowledge is a valuable source of competitive advantage. However, there appear to be no empirical studies that have explicitly tested this theory in the Kenyan context. The current theory fills this gap. The study followed a post-positivist critical realism philosophical orientation and used a cross-sectional survey design approach. Accordingly, data was elicited from study participants using a self-administered survey instrument. The population for the study was the ICT content service providers licensed by the Communications Authority of Kenya (CAK), a fertile ground for ICT knowledge creation and dissemination. Out of the target population of 197 ICT content service providers licensed by the CAK, 135 firms provided valid responses to the survey. The study showed that organizational learning was a strong mediator of the influence of tacit knowledge on competitive advantage. The study is an additional building block in strategic management theories that show the importance of continuous enhancement of the productive knowledge of individuals as a driver of competitive advantage for an organization, particularly the Knowledge-Based View and Organizational Learning Theory. The insights from the study will motivate policy makers and strategic management practitioners to embrace and promote tacit knowledge and organizational learning practices in their respective organizations.