Miracle-dz/UniFAR-FTUs huggingface dataset:
Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials

Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of probiotic supplementation to improve micronutrient status in healthy subjects. The authors searched for published English language peer-reviewed journal articles in PubMed, Scopus, Embase, and Google Scholar databases from inception to July 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of eligible studies was assessed using the Revised Cochrane Risk-of-Bias tool (RoB)2 and Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-I tool). Fourteen original studies out of 2790 met the inclusion criteria. The results indicated that, despite varying degrees of efficacy, the intake of certain probiotics in healthy subjects was associated with a positive impact on the status of certain micronutrients (vitamin B12, calcium, folate, iron and zinc). A limitation was that studies were widely heterogeneous in terms of participant age, probiotic strain, species, dosage, intervention duration, and form of administration. Additional clinical trials are warranted to determine the most effective strains of probiotics, doses and durations of interventions.
First-Year College Student Life Experiences during COVID-19 in South Korea

The purpose of this study is to examine the first-year students’ experience in college during the COVID-19 pandemic to provide a better understanding of their daily life. Using inductive content analysis, this study examined the characteristics and experiences of students who started college during the COVID-19 period in South Korea. We analyzed 623 pieces of content, using data presented by a total of 81 study subjects. From this analysis, we derived 22 primary keywords, which we divided into eight categories, and then reclassified into three general topics: self-awareness (i.e., self-reflection), activities (i.e., engagement in activities), and resources (i.e., creating relationships or producing results). The results showed that, although first-year college students experienced difficulties in adapting to the COVID-19 situation, they tried to cope with them. Our findings shed light on the experiences of college students who experienced psychological problems during the COVID-19 pandemic and overcame related challenges.
Wastewater-Based Epidemiology and Long-Read Sequencing to Identify Enterovirus Circulation in Three Municipalities in Maricopa County, Arizona, Southwest United States between June and October 2020

We used wastewater-based epidemiology and amplicon-based long-read high-throughput sequencing for surveillance of enteroviruses (EVs) in Maricopa County, Arizona, Southwest United States. We collected 48 samples from 13 sites in three municipalities between 18 June and 1 October 2020, and filtered (175 mL each; 0.45 µm pore size) and extracted RNA from the filter-trapped solids. The RNA was converted to cDNA and processed through two workflows (Sanger sequencing (SSW) and long-read Illumina sequencing (LRISW)) each including a nested polymerase chain reaction (nPCR) assay. We subjected the ~350 bp amplicon from SSW to Sanger sequencing and the ~1900–2400 bp amplicon from LRISW to Illumina sequencing. We identified EV contigs from 11 of the 13 sites and 41.67% (20/48) of screened samples. Using the LRISW, we detected nine EV genotypes from three species (Enterovirus A (CVA4, EV-A76, EV-A90), Enterovirus B (E14) and Enterovirus C (CVA1, CVA11, CVA13, CVA19 and CVA24)) with Enterovirus C representing approximately 90% of the variants. However, the SSW only detected the five Enterovirus C types. Similarity and phylogenetic analysis showed that multiple Enterovirus C lineages were circulating, co-infecting and recombining in the population during the season despite the SARS-CoV-2 pandemic and the non-pharmaceutical public health measures taken to curb transmission.
Automatic Inside Point Localization with Deep Reinforcement Learning for Interactive Object Segmentation

In the task of interactive image segmentation, the Inside-Outside Guidance (IOG) algorithm has demonstrated superior segmentation performance leveraging Inside-Outside Guidance information. Nevertheless, we observe that the inconsistent input between training and testing when selecting the inside point will result in significant performance degradation. In this paper, a deep reinforcement learning framework, named Inside Point Localization Network (IPL-Net), is proposed to infer the suitable position for the inside point to help the IOG algorithm. Concretely, when a user first clicks two outside points at the symmetrical corner locations of the target object, our proposed system automatically generates the sequence of movement to localize the inside point. We then perform the IOG interactive segmentation method for precisely segmenting the target object of interest. The inside point localization problem is difficult to define as a supervised learning framework because it is expensive to collect image and their corresponding inside points. Therefore, we formulate this problem as Markov Decision Process (MDP) and then optimize it with Dueling Double Deep Q-Network (D3QN). We train our network on the PASCAL dataset and demonstrate that the network achieves excellent performance.
The COVID-19 Pandemic: A Longitudinal Study on the Emotional-Behavioral Sequelae for Children and Adolescents with Neuropsychiatric Disorders and Their Families

This study aimed to investigate the immediate and short-term impact of the pandemic on the psychological well-being of Italian children and adolescents with psychiatric disorders and their families. Overall, 56 patients aged 6–18 (M = 13.4 years, SD = 2.77) and their parents were evaluated during the COVID-19 lockdown (T0) and after 4 months (T1). An ad hoc data sheet, Youth Self-Report 11–18 (YSR), Child Behavior Checklist 6–18 (CBCL), and Depression Anxiety Stress Scale-21 (DASS-21) were administered. Patients, mainly suffering from internalizing disorders, overall demonstrated a good adaptation to the pandemic context. Moreover, patients with behavioral disorders showed a greater psychological discomfort at both T0 and T1 compared to patients with internalizing disorders. Over time, patients presented an improvement on the emotional side, as proven by a significant decrease in internalizing and post-traumatic stress problems. Finally, no significant differences were found in the emotional-behavioral profile of patients according to the means of conducting neuropsychiatric interventions during the lockdown (i.e., in person/remotely/interrupted), thus allowing us to exclude important negative effects caused by the transition to remote therapy. Concerning parents, an inverse relationship emerged between the DASS-21 scores and the level of resilience, which therefore represents a protective factor against psychological maladjustment. Over time, an improvement in the psychological well-being of parents was observed, as shown by a significant decrease in mothers’ anxiety and fathers’ stress.
Identification of Chemical Bonds and Microstructure of Hydrated Tricalcium Silicate (C3S) by a Coupled Micro-Raman/BSE-EDS Evaluation

Identifying the phase evolution and revealing the chemical bonds of hydrated cements accurately is crucial to regulate the performance of cementitious materials. In this paper, a coupled Raman/BSE-EDS analysis was proposed to determine the chemical bonds of tricalcium silicate hydrates and the interface transition zone (ITZ) between inner C-S-H and anhydrates. The results show that the Raman/BSE-EDS method can accurately identify the chemical bonds of inner C-S-H and inner ITZ regions, which confirms the mixed structure of inner C-S-H and nano calcium hydroxide (CH). The inner ITZ shows a lattice change region with a thickness of 700–1000 nm, which can be attributed to the pre-disassembly process of C3S crystal. The successful application of coupled Raman/BSE-EDS provides new insight into the hydration process and multi-structure features of traditional cementitious materials.
Genotype of Immunologically Hot or Cold Tumors Determines the Antitumor Immune Response and Efficacy by Fully Virulent Retargeted oHSV

We report on the efficacy of the non-attenuated HER2-retargeted oHSV named R-337 against the immunologically hot CT26-HER2 tumor, and an insight into the basis of the immune protection. Preliminarily, we conducted an RNA immune profiling and immune cell content characterization of CT26-HER2 tumor in comparison to the immunologically cold LLC1-HER2 tumor. CT26-HER2 tumor was implanted into HER2-transgenic BALB/c mice. Hallmarks of R-337 effects were the protection from primary tumor, long-term adaptive vaccination directed to both HER2 and CT26-wt cell neoantigens. The latter effect differentiated R-337 from OncoVEXGM-CSF. As to the basis of the immune protection, R-337 orchestrated several changes to the tumor immune profile, which cumulatively reversed the immunosuppression typical of this tumor (graphical abstract). Thus, Ido1 (inhibitor of T cell anticancer immunity) levels and T regulatory cell infiltration were decreased; Cd40 and Cd27 co-immunostimulatory markers were increased; the IFNγ cascade was activated. Of note was the dampening of IFN-I response, which we attribute to the fact that R-337 is fully equipped with genes that contrast the host innate response. The IFN-I shut-down likely favored viral replication and the expression of the mIL-12 payload, which, in turn, boosted the antitumor response. The results call for a characterization of tumor immune markers to employ oncolytic herpesviruses more precisely.
Prevalence and contextual factors associated with compassion fatigue among nurses in northern Uganda

Background Compassion fatigue is associated with negative consequences that undermine workplace performance. However, literature is scarce on compassion fatigue among nurses in the context of Uganda who are at higher risk of compassion fatigue owed to the nature of their occupation and the unfavorable work environment. We aimed to assess the prevalence and predictors of compassion fatigue among nurses in Northern Uganda. Methods We conducted a cross-sectional survey among 395 randomly selected nurses from two referral and four general hospitals in Northern Uganda. Data was collected using a self-administered questionnaire. Data analysis consisted of descriptive statistics, cross-tabulations, and logistic regression at a 95% level of significance in SPSS version 25. Results Of 395 nurses who took part in the study, 58.2% were female, 39.8% had a diploma, 47.1% were single, and 32.4% had worked for between 11–15 years. Close to 50% of the nurses experienced compassion fatigue. The predictors of compassion fatigue among the participants were; workplace bullying (AOR: 3.83; 95% CI: 1.99–7.36; p = <0.001) career enhancement opportunities (AOR: 9.16; 95% CI: 2.32–36.22; p = 0.002; and remuneration (AOR: 7.30; 95% CI: 2.73–19.49; p = <0.001). Conclusion More than 3 in 4 nurses in Northern Uganda experience compassion fatigue. The Ministry of Health together with other stakeholders should strive to increase career enhancement opportunities for nurses, improve nurses’ remuneration and improve the overall workplace environment to prevent compassion fatigue among nurses in the country.
Rhabdomyolysis Following Ad26.COV2.S COVID-19 Vaccination

We report the case of a 19-year-old male who complained of myalgia, muscle weakness, and darkened urine two days after receiving his Ad26.COV2. S (Johnson & Johnson, New Brunswick, New Jersey, United States) COVID-19 vaccination. Blood examination revealed an increased creatine kinase (CK) level, and his urinary dipstick tested positive for blood, indicative of acute rhabdomyolysis. Serum creatinine levels were normal. Rhabdomyolysis due to strenuous physical activity was ruled out and further diagnostics excluded an autoimmune cause. Under repeated treatment with intravenous fluid resuscitation (outpatient treatment), his symptoms resolved and peak CK levels of 44,180 U/L returned to almost normal levels within two weeks. Rhabdomyolysis is a rare, potentially fatal vaccine-induced reaction. Further research is needed to better understand the underlying pathomechanism and to investigate whether subcutaneous injection of vaccines may be able to prevent rhabdomyolysis.
A Finite Element Study to Investigate the Mechanical Behaviour of Unidirectional Recycled Carbon Fibre/Glass Fibre–Reinforced Epoxy Composites

Recycled carbon fibre–reinforced epoxy (rCF/EP) composites and recycled glass fibre–reinforced epoxy (rGF/EP) composites were numerically investigated to examine their mechanical properties, such as uniaxial tensile and impact resistance, using finite element (FE) methods. The recycled composites possess unidirectional, long and continuous fibre arrangements. A commercially available Abaqus/CAE software was used to perform an explicit non-linear analysis with a macroscale modelling approach, assuming the recycled composites as both homogenous and isotropic hardening. Five composite types were subjected to a numerical study based on the recycled fibre’s volume fraction (40 and 60%) of rCF/EP and rGF/EP, along with (100%) fibreless cured epoxy samples. The materials were defined as elastoplastic with a continuum ductile damage (DUCTCRT) model. The experimental tensile test results were processed and calibrated as primary input data for the developed FE models. The numerical tensile results, maximum principal stress and logarithmic strain were validated with their respective experimental results. The stress–strain curves of both results possess a high accuracy, supporting the developed FE model. The numerical impact tests examined the von Mises stress distribution and found an exponential decrease in the stiffness of the composite types as their strength decreased, with the 60% rCF/EP sample being the stiffest. The model was sensitive to the mesh size, hammer velocity and simulation time step. Additionally, the total internal energy and plastic dissipation energy were measured, but were higher than the experimentally measured energies, as the FE models eliminated the defects from the recycled process, such as a poor fibre wettability to resin, fibre bundle formation in rCFs and char formation in rGFs. Overall, the developed FE models predicted the results for a defect-free rCF/EP and rGF/EP composite. Hence, the adopted modelling techniques can validate the experimental results of recycled composites with complex mechanical properties and damage behaviours in tensile and impact loading conditions.
Dual Effect of Organogermanium Compound THGP on RIG-I-Mediated Viral Sensing and Viral Replication during Influenza a Virus Infection

The interaction of viral nucleic acid with protein factors is a crucial process for initiating viral polymerase-mediated viral genome replication while activating pattern recognition receptor (PRR)-mediated innate immune responses. It has previously been reported that a hydrolysate of Ge-132, 3-(trihydroxygermyl) propanoic acid (THGP), shows a modulatory effect on microbial infections, inflammation, and immune responses. However, the detailed mechanism by which THGP can modify these processes during viral infections remained unknown. Here, we show that THGP can specifically downregulate type I interferon (IFN) production in response to stimulation with a cytosolic RNA sensor RIG-I ligand 5′-triphosphate RNA (3pRNA) but not double-stranded RNA, DNA, or lipopolysaccharide. Consistently, treatment with THGP resulted in the dose-dependent suppression of type I IFN induction upon infections with influenza virus (IAV) and vesicular stomatitis virus, which are known to be mainly sensed by RIG-I. Mechanistically, THGP directly binds to the 5′-triphosphate moiety of viral RNA and competes with RIG-I-mediated recognition. Furthermore, we found that THGP can directly counteract the replication of IAV but not EMCV (encephalitismyocarditis virus), by inhibiting the interaction of viral polymerase with RNA genome. Finally, IAV RNA levels were significantly reduced in the lung tissues of THGP-treated mice when compared with untreated mice. These results suggest a possible therapeutic implication of THGP and show direct antiviral action, together with the suppressive activity of innate inflammation.
Objective Measurement of 24-Hour Movement Behaviors in Preschool Children Using Wrist-Worn and Thigh-Worn Accelerometers

In recent years, more attention has been paid towards the study of 24-h movement behaviors (including physical activity (PA), sedentary behavior (SB) and sleep) in preschoolers instead of studying these behaviors in isolation. This study aimed to evaluate the feasibility of using wrist- vs. thigh-worn accelerometers and to report accelerometer-derived metrics of 24-h movement behaviors in preschoolers. A convenience sample of 16 preschoolers (50.0% boys, 4.35 years) and one of their parents were recruited for this study. Preschoolers had to wear the ActivPAL accelerometer (attached to the upper thigh) and Axivity accelerometer (using a wrist band) simultaneously for 7 consecutive days and for 24 h a day. Parents completed an acceptability survey. In total, 16 preschoolers (100.0%) had a minimum of 6 days of valid wrist-worn data, while only 10 preschoolers (62.5%) had a minimum of 6 days of valid thigh-worn data (p = 0.002). When looking at the acceptability, 81.3% of parents indicated that it was easy for their child to wear the Axivity for 7 consecutive days, and 93.8% of parents indicated so for the ActivPAL (p = 0.88). However, some parents stated that the wristband of the Axivity accelerometer was big, which might have affected data collection. Significant differences were found for the measurement of total volume of PA, SB and sleep across 24 h. Total PA was 464.44 min/day (±64.00) with the ActivPAL compared with 354.94 min/day (±57.46) with the Axivity (p < 0.001). The volume of SB was 290.94 min/day (±55.05) with the ActivPAL compared with 440.50 min/day (±50.01) with the Axivity (p < 0.001). The total volume of sleep was also significantly different between both devices (p = 0.001; ActivPAL: 684.63 min/day ± 51.96; Axivity: 645.69 min/day ± 46.78). Overall, parents perceived both devices to be feasible to use for preschoolers. However, future studies are required to validate both devices for the measurement of preschoolers’ 24-h movement behaviors since significant differences in the classification of PA, SB and sleep were found in this small sample.
Take a Bite! The Effect of Bitten Food in Pictures on Product Attitudes, Purchase Intentions, and Willingness to Pay

Food pictures in advertisements, on packages, and on social media often display food with a bite in it. We investigated the effect of pictures of food with a bite (vs. no bite) on product attitudes, purchase intentions, and willingness to pay. In two online experimental studies we tested this effect for both pictures without context, as well as pictures in an advertisement. We also investigated two theories that could lead to opposite effects: consumer contamination and embodied mental simulation. We found that a picture of food with a bite (vs. no bite) resulted in lower purchase intentions, and that this effect was mediated by disgust (i.e., consumer contamination). Furthermore, we found an interaction effect of picture type (i.e., bite vs. no bite) and context (i.e., no context vs. advertisement) on purchase intentions: the effect of picture type on purchase intentions was attenuated when the picture appeared in an advertisement (vs. when the picture is shown without context). We found similar effects on product attitudes and willingness to pay. Lastly, a picture of food with a bite (vs. no bite) had no effect on embodied mental simulation. Field practitioners are advised to take caution when using pictures of bitten food as this may lead to unfavorable consumer responses because of a feeling if disgust.
Subjective Experiences of Mental Health Crisis Care in Emergency Departments: A Narrative Review of the Qualitative Literature

Mental health presentations to the emergency department (ED) have increased, and the emergency department has become the initial contact point for people in a mental health crisis. However, there is mounting evidence that the ED is not appropriate nor effective in responding to people in mental health crises. Insufficient attention has been paid to the subjective experience of people seeking support during a mental health crisis. This review aims to describe the qualitative literature involving the subjective experiences of people presenting to the ED during a mental health crisis. The method was guided by Arksey and O’Malley’s framework for scoping studies and included keyword searches of PsycINFO, CINAHL, Medline and Embase. A narrative analysis, drawing on the visual tool of journey mapping, was applied to summarise the findings. Twenty-three studies were included. The findings represent the experience of accessing EDs, through to the impact of treatment. The review found points of opportunity that improve people’s experiences and characteristics associated with negative experiences. The findings highlight the predominance and impact of negative experiences of the ED and the incongruence between the expectations of people presenting to the ED and the experience of treatment.
Eccentric Hamstring Muscle Strength during Home Confinement Due to the COVID-19 Pandemic, and Football Competition Resumption in Professional Football Referees: A Prospective Observational Study

The COVID-19 pandemic has produced a major disruption for professional football leagues that has affected the physical preparation of both football players and referees. In Spain, health authorities decreed home confinement for eight weeks, supressing the normal training routines of professional referees. After home confinement, referees had four weeks to retrain as the national football league was set to resume matches to complete the 11 games remaining. The aim of the present investigation was to assess changes in eccentric hamstring muscle strength during football competition suspension/resumption due to the COVID-19 pandemic in 21 professional football referees (mean ± SD, age: 33.4 ± 5.1 years; height: 182.4 ± 5.0 cm; body mass: 75.1 ± 4.4 kg). Eccentric hamstring muscle strength was measured with the Nordic hamstring exercise at four time points. During home confinement, referees presented the lowest value of bilateral eccentric muscle strength (300 ± 14 N). Eccentric muscle strength increased by 13.2 ± 3.7% one week after the end of home confinement (339 ± 16 N; p = 0.001, effect size (ES) = 2.8) and remained stable before the first match (343 ± 17 N; p = 0.001, ES = 3.1) and after the end of the national league (328 ± 13 N; p = 0.001, ES = 2.0). In summary, home confinement produced detraining effects in professional football referees associated with hamstring muscle weakness. In this regard, strength-based activities with body loads may be insufficient to avoid muscle weakness and other means (e.g., weights) may be necessary to maintain muscle strength. However, the 4-weeks retraining period was sufficient to resolve hamstring muscle weakness induced by the restrictions of home confinement. This information may be helpful in the case of future sport competition suspension or home quarantine due to new waves of COVID-19 pandemic.