Miracle-dz/UniFAR-FTUs huggingface dataset:
Electroencephalography Mu Rhythm Changes and Decreased Spasticity After Repetitive Peripheral Magnetic Stimulation in Patients Following Stroke

Background: Spasticity is common among patients with stroke. Repetitive peripheral magnetic stimulation (rPMS) is a painless and noninvasive therapy that is a promising approach to reducing spasticity. However, the central mechanism of this therapy remains unclear. Changes in cortical activity and decreased spasticity after rPMS intervention require further exploration. The aim of this study was to explore the electroencephalography (EEG) mu rhythm change and decrease in spasticity after rPMS intervention in patients with stroke. Materials and methods: A total of 32 patients with spasticity following stroke were recruited in this study and assigned to the rPMS group (n = 16) or sham group (n = 16). The modified Ashworth scale, modified Tardieu scale, and Fugl–Meyer assessment of the upper extremity were used to assess changes in upper limb spasticity and motor function. Before and after the rPMS intervention, EEG evaluation was performed to detect EEG mu rhythm changes in the brain. Results: After one session of rPMS intervention, spasticity was reduced in elbow flexors (p < 0.05) and wrist flexors (p < 0.05). Upper limb motor function measured according to the Fugl–Meyer assessment was improved (p < 0.05). In the rPMS group, the power of event-related desynchronization decreased in the mu rhythm band (8–12 Hz) in the contralesional hemisphere (p < 0.05). Conclusions: The results indicate that rPMS intervention reduced spasticity. Cortical activity changes may suggest this favorable change in terms of its neurological effects on the central nervous system.
Evaluation of Early Retinal Nerve Injury in Type 2 Diabetes Patients Without Diabetic Retinopathy

Objectives: To investigate the damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex layer (GCL+) in diabetic patients without retinal microangioma and to determine the kind of nerve damage more likely to indicate early injury. Subjects and Methods: We included 360 patients (360 eyes) with type 2 diabetes mellitus and 168 healthy volunteers (168 eyes). Patients with retinal microangioma were excluded by fundus fluorescein angiography (FFA). The parameters around the optic disc and macular area were measured by optical coherence tomography (OCT). Results: The peripapillary RNFL thickness was thinner in the temporal (72.98 ± 13.76 μm, P < 0.0001) and inferior (120.71 ± 21.43 μm, P = 0.0103) sectors in patients with no diabetic retinopathy (NDR) compared to healthy controls. The reduction of retinal thickness in the macular region was prominent in the inferior sector in patients (34.74 ± 4.92 μm, P < 0.0001) compared to normal controls. Thinning of GCL+ in the second region of the macular area was significant in patients with NDR compared to normal controls (P < 0.05). However, no difference in the GCL+ and retinal thicknesses of the central macular region was observed between the patients with NDR and healthy controls. Using the 5th percentile (P5) of normal controls as the reference value, we found that the parameters with the highest indices in patients with NDR were the inferior and temporal peripapillary RNFL thickness (13.0%), the inferior RNFL thickness in the macular area (20%), the inferior retinal thickness in the outer ring of the macular area (10.8%), and the inferior GCL+ thickness in the macular area (10.6%). The GCL+ and RNFL thicknesses in the central macular area accounted for the smallest proportion in P5 of normal controls (3%). Conclusions: Retinal nerve injury can occur in patients without retinal microangioma. The inferior RNFL in the macular area and the inferior and temporal peripapillary RNFL were most sensitive to glucose damage. These areas might be associated with early detection of diabetic retinopathy (DR) as they are more likely to indicate early damage.
The Compression of the Heliospheric Magnetic Structure by Interplanetary Shocks: Is the Structure at 1AU a Manifestation of Solar-Wind Turbulence or Is It Fossil Structure From the Sun?

As a test of the action of MHD turbulence in the solar wind, the compression of the heliospheric magnetic structure at 1AU by 109 interplanetary shocks is examined. In the magnetic structure the orientations of solar-wind strong current sheets are statistically examined vs. time in the downstream plasmas after shock compression. If the current sheets of the solar wind are features of an active MHD turbulence, they should be destroyed and remade with isotropic orientations on the timescale of an eddy-turnover time. If the current-sheet orientations remain anisotropic after the shock compression, it is an indication that the current sheets of the solar wind are not created by MHD turbulence. This statistical analysis finds no evolution of the current-sheet orientations after the solar wind is compressed by the shocks, implying a non-turbulent origin of the current sheets. A possibility is that the heliospheric magnetic structure at 1 AU is fossil structure from the solar corona.
Physiological and Pathological Regulation of Peripheral Metabolism by Gut-Peptide Hormones in Drosophila

The gastrointestinal (GI) tract in both vertebrates and invertebrates is now recognized as a major source of signals modulating, via gut-peptide hormones, the metabolic activities of peripheral organs, and carbo-lipid balance. Key advances in the understanding of metabolic functions of gut-peptide hormones and their mediated interorgan communication have been made using Drosophila as a model organism, given its powerful genetic tools and conserved metabolic regulation. Here, we summarize recent studies exploring peptide hormones that are involved in the communication between the midgut and other peripheral organs/tissues during feeding conditions. We also highlight the emerging impacts of fly gut-peptide hormones on stress sensing and carbo-lipid metabolism in various disease models, such as energy overload, pathogen infection, and tumor progression. Due to the functional similarity of intestine and its derived peptide hormones between Drosophila and mammals, it can be anticipated that findings obtained in the fly system will have important implications for the understanding of human physiology and pathology.
The Temporality of Situated Cognition

Situated cognition embeds perceptions, thoughts, and behavior within the contextual framework of so-called “4E cognition” understanding cognition to be embodied, enactive, extended, and embedded. Whereas this definition is primarily based on the spatial properties of a situation, it neglects a fundamental constituent: the cognitive situation as enduring. On a subpersonal level, situated cognition requires the integration of information processing within a minimal temporal extension generating the basic building blocks of perception and action (“microlayer” of time). On a personal level, lived situations and experienced narratives leading to our biography can be defined by their broader temporal horizons (“macrolayer” of time). The macrolayer of time is based on and emerges from information processing on the microlayer of time. Whereas the constraints on the microlayer are primarily defined by the integrity of neurobiological processes within an individual cognitive system, the temporal horizons and subsequently the situational context on the macrolayer are defined by the complex affordances of a situation on a personal or interpersonal level. On both time layers, cognition can be defined as a continuous dynamic process, reflecting the transition from one situated state to another. Taken together, the events forming the delimiting horizons of these situations correspond to the temporal structure of the cognitive process along which it continuously proceeds. The dynamic driving and enabling this transition from state to state is synonymous with the inherent flow of time. Just as the layers of time, flow and structure, are inseparably connected. The integration of temporal flow and temporal structure into the continuous dynamic process constitutes the enduring situatedness of cognition. By providing everyday examples and examples from psychopathology, we highlight the benefits of understanding cognitive processes as part of enduring situations.
Effects of a Mindfulness Intervention Among Arab Teachers Are Mediated by Decentering: A Pilot Study

Although mindfulness-based interventions (MBIs) in education are widely spreading in the world, examination of mindfulness effects in Arab schools is still scarce. This pilot study aimed to fill this gap by examining the effects of an MBI among Arab teachers in Israel. This examination was conducted within the framework of the mindful self in school relationships (MSSR) model, which suggests that the positive effects of MBI on teachers’ emotion regulation are mediated by decentering. The participants (N = 39) were teachers from two Arab elementary schools in Israel, who underwent an MBI course (the MBI condition, N = 20) and another cognitive intervention (the control condition, N = 19). In a pre–post design, participants completed mindfulness, decentering, emotion regulation, and stress questionnaires. We hypothesized that (1) only in the MBI group, teachers’ mindfulness, decentering, and emotional regulation will increase and stress will decrease, and (2) changes in teachers’ decentering would mediate the associations of changes in teachers’ mindfulness with changes in their emotion regulation. ANOVA analyses show that, only in the MBI condition, teachers showed an increase in three mindfulness subscales (acting with awareness, non-reactivity, and observance), in decentering, and in adaptive emotion regulation (reappraisal) and a decrease in stress. Furthermore, changes from pre-intervention to post-intervention in teachers’ decentering mediated the associations of their pre–post changes in mindfulness with changes in emotion regulation. This study provides initial support to the feasibility and efficacy of MBI among Israeli Arab teachers and suggests decentering as a potential mediator of its effects in initial support of the MSSR model.
Cybervictimization, Depression, and Adolescent Internet Addiction: The Moderating Effect of Prosocial Peer Affiliation

Although vast research has shown that cybervictimization is a significant risk factor of adolescent’s internet addiction (IA), little is known about the mediating and moderating mechanisms behind this relationship. The current study examined whether depression mediated the relationship between cybervictimization and adolescent’s IA, and whether the direct and indirect effect was moderated by prosocial peer affiliation (PPA). A sample of 1,006 adolescents (Meanage = 13.16; SD = 0.67) anonymously completed the questionnaires. The results revealed that the positive association between cybervictimization and adolescent’s IA was mediated by depression. Moderated mediation analysis further showed that PPA moderated the association between cybervictimization and adolescent’s IA. However, this indirect effect was stronger for adolescents with high PPA than for those with low PPA, which means that the protective effects of PPA are limited. These findings highlight the mediating and moderating mechanisms between cybervictimization and adolescent’s IA, and provide guidance for the prevention and intervention in adolescent’s IA.
The Unfolded Protein Response and Autophagy as Drug Targets in Neuropsychiatric Disorders

Neurons are polarized in structure with a cytoplasmic compartment extending into dendrites and a long axon that terminates at the synapse. The high level of compartmentalization imposes specific challenges for protein quality control in neurons making them vulnerable to disturbances that may lead to neurological dysfunctions including neuropsychiatric diseases. Synapse and dendrites undergo structural modulations regulated by neuronal activity involve key proteins requiring strict control of their turnover rates and degradation pathways. Recent advances in the study of the unfolded protein response (UPR) and autophagy processes have brought novel insights into the specific roles of these processes in neuronal physiology and synaptic signaling. In this review, we highlight recent data and concepts about UPR and autophagy in neuropsychiatric disorders and synaptic plasticity including a brief outline of possible therapeutic approaches to influence UPR and autophagy signaling in these diseases.
Efficient White Electrochemiluminescent Emission From Carbon Quantum Dot Films

Carbon quantum dots (CQDs) were manufactured from citric acid and urea in a gram-scale synthesis with a controlled size range between 1. 5 and 23.8 nm. The size control was realized by varying volume of the precursor solution in a hydrothermal synthesis method. The prepared CQDs were investigated using electrochemiluminescence (ECL) spectroscopy at interfaces of their electrode films and electrolyte solution containing coreactants rather than conventional optoelectronic tests, providing an in-depth analysis of light-emission mechanisms of the so-called half-cells. ECL from the CQD films with TPrA and K2S2O8 as coreactants provided information on the stability of the CQD radicals in the films. It was discovered that CQD•− has a powerful electron donating nature to sulfate radical to generate ECL at a relative efficiency of 96% to the Ru(bpy)3Cl2/K2S2O8 coreactant system, indicating a strong performance in light emitting applications. The smaller the CQD particle sizes, the higher the ECL efficiency of the film interface, most likely due to the increased presence of surface states per mass of CQDs. Spooling ECL spectroscopy of the system revealed a potential-dependent light emission starting from a deep red color to blue-shifted intensity maximum, cool bright white emission with a correlated color temperature of 3,200 K. This color temperature is appropriate for most indoor lighting applications. The above ECL results provide information on the performance of CQD light emitters in films, permitting preliminary screening for light emitting candidates in optoelectronic applications. This screening has revealed CQD films as a powerful and cost-effective light emitting layer toward lighting devices for indoor applications.
Screening of complex bioflocculant producing bacteriumand their flocculating mechanism

Twelve strains of bacteria, which had the ability of producing bioflocculant, were obtained among 132 bacterial strains isolated from activated sludge samples. The flocculating efficiencies for F2, F3, F5 and F6 were all above 80%. Taking cellulose as substrate, which contains decomposing bacteria and flocculants-producing bacteria, a kind of complex bioflocculant (HITM02) was obtained through two-step fermentation. Every two strains of the bacteria among the 4 strains obtained above were selected to process the mixed culture by orthogonal experiment. Results showed that the combination of F2 and F6 strains possessed the best flocculating activity and was higher than that of any pure strains. It had been confirmed that effective compositions of HITM02 were polysaccharide (1.76%), protein and polypeptide (5.4%). These materials together with the fermentation residue of the cellulose possess the flocculating effect. The flocculating mechanisms of complex bioflocculants include: (1) adsorption and charge neutralization of ampholyte such as protein and polypeptide, (2) bridging of polysaccharide and the cellulose fermentation residue.
The Long-Term Life-Cycle of Nevado de Toluca Volcano (Mexico): Insights Into the Origin of Petrologic Modes

The petrologic diversity of volcanic rocks reflects the dynamics of magma reservoirs and the temporal evolution of magma chemistry can provide valuable information for hazard assessment. While some stratovolcanoes monotonously produce intermediate magmas (55–68 wt% SiO2), dominantly erupted magma types (e.g., basaltic andesite, andesite or dacite) frequently differ even between neighboring volcanoes. If such differences arise due to thermal maturation processes over time or are predetermined by other properties of magmatic systems remains poorly understood. This study helps to elucidate the underlying factors modulating the chemistry of the magma preferentially erupted by Nevado de Toluca volcano in Central Mexico. We present a new dataset of bulk-rock and mineral chemistry spanning the entire 1.5 Million years of the volcanos’ eruptive history. The results reveal that Nevado de Toluca dacites and minor andesite originate in a stable configuration of pre-eruptive processes and plumbing system architecture by hybridization between an upper crustal silicic mush and deeper sourced basaltic andesite magmas. Yet, a subtle trend toward increasing silica content with time (2 wt% in 1.5 Ma) and episodicity in magma hybridization conditions are observed. We use thermal simulations of pulsed magma injection to probe the controlling variables on the temporal variation and compositional mode of magma geochemistry. The results show that the subtle temporal trend toward increasing bulk-rock SiO2 content is plausibly explained by slightly dropping recharge rates and continued upper crustal reservoir growth. Our modeling also shows that the dominant composition of eruptible magmas (“petrologic mode”) can shift as a function of magma flux, extrusive:intrusive ratio and temperature of the recharge magma. A comparison of SiO2 whole rock distributions for monotonous Mexican stratovolcanoes and their peripheral cones shows that their petrologic modes vary in concert, indicating that the recharge magma chemistry or temperature is a major control on the preferentially erupted magma composition for these volcanoes.
Identification of Signatures of Prognosis Prediction for Melanoma Using a Hypoxia Score

Melanoma is one of the most aggressive cancers. Hypoxic microenvironment affects multiple cellular pathways and contributes to tumor progression. The purpose of the research was to investigate the association between hypoxia and melanoma, and identify the prognostic value of hypoxia-related genes. Based on the GSVA algorithm, gene expression profile collected from The Cancer Genome Atlas (TCGA) was used for calculating the hypoxia score. The Kaplan–Meier plot suggested that a high hypoxia score was correlated with the inferior survival of melanoma patients. Using differential gene expression analysis and WGCNA, a total of 337 overlapping genes associated with hypoxia were determined. Protein-protein interaction network and functional enrichment analysis were conducted, and Lasso Cox regression was performed to establish the prognostic gene signature. Lasso regression showed that seven genes displayed the best features. A novel seven-gene signature (including ABCA12, PTK6, FERMT1, GSDMC, KRT2, CSTA, and SPRR2F) was constructed for prognosis prediction. The ROC curve inferred good performance in both the TCGA cohort and validation cohorts. Therefore, our study determined the prognostic implication of the hypoxia score in melanoma and showed a novel seven-gene signature to predict prognosis, which may provide insights into the prognosis evaluation and clinical decision making.
Philosophical racism and ubuntu: In dialogue with Mogobe Ramose

This article discusses two complementary themes that play an important role in contemporary South African political philosophy: (1) the racist tradition in Western philosophy; and (2) the role of ubuntu in regaining an authentic African identity, which was systematically suppressed during the colonial past and apartheid. These are also leading themes in Mogobe Ramose’s African Philosophy Through Ubuntu. The first part concentrates on John Locke. It discusses the thesis that the reprehensible racism of many founders of liberal political philosophy has lethally infected liberal theory. This view neglects the distinction between genesis and justification. Political liberalism has since cleansed itself of the prejudices of its spiritual ancestors. Liberal human rights exclude racism as a matter of principle. The second part discusses the claim that the ubuntu philosophy provides a better basis for a constitution in a modern society than political liberalism. A major problem is that ubuntu is an essentially contested concept. Some philosophers consider ubuntu to be a moribund notion (Matolino); others see it as a vital concept par excellence. In the latter case, it is elaborated from sundry incompatible political views, ranging from African nationalism (Ramose) via humanist communitarianism (Metz) to liberalism (Mboti). Conclusion: as an essentially contested ideological concept, ubuntu should not be a decisive constitutional standard for the application of state force. In contrast, the constitutional model of political liberalism provides a reasonable alternative, as it is designed precisely to solve the problem of social plurality and ideological contest.
Spatio-Temporal Classification Framework for Mapping Woody Vegetation from Multi-Temporal Sentinel-2 Imagery

The inventory of woody vegetation is of great importance for good forest management. Advancements of remote sensing techniques have provided excellent tools for such purposes, reducing the required amount of time and labor, yet with high accuracy and the information richness. Sentinel-2 is one of the relatively new satellite missions, whose 13 spectral bands and short revisit time proved to be very useful when it comes to forest monitoring. In this study, the novel spatio-temporal classification framework for mapping woody vegetation from Sentinel-2 multitemporal data has been proposed. The used framework is based on the probability random forest classification, where temporal information is explicitly defined in the model. Because of this, several predictions are made for each pixel of the study area, which allow for specific spatio-temporal aggregation to be performed. The proposed methodology has been successfully applied for mapping eight potential forest and shrubby vegetation types over the study area of Serbia. Several spatio-temporal aggregation approaches have been tested, divided into two main groups: pixel-based and neighborhood-based. The validation metrics show that determining the most common vegetation type classes in the neighborhood of 5 × 5 pixels provides the best results. The overall accuracy and kappa coefficient obtained from five-fold cross validation of the results are 82.97% and 0.75, respectively. The corresponding producer’s accuracies range from 36.74% to 97.99% and user’s accuracies range from 46.31% to 98.43%. The proposed methodology proved to be applicable for mapping woody vegetation in Serbia and shows a potential to be implemented in other areas as well. Further testing is necessary to confirm such assumptions.