Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) with imported donor corneas in eyes of Asian patients; endothelium‐in versus endothelium‐out method

Objective We investigated whether (1) imported pre-cut tissue is feasible for Descemet membrane endothelial keratoplasty (DMEK) in eyes of Asian patients, (2) the clinical outcome is comparable between the endothelium‐in and endothelium‐out methods, and (3) the corneal edema-induced anterior curvature changes may have an effect on the refractive error. Methods The medical records of 32 DMEK patients who underwent either the endothelium-out or endothelium-in method using imported pre-cut grafts with a 3-day pre-cut-to-use time were retrospectively analyzed. Fuchs’ endothelial dystrophy (37.5%) and bullous keratopathy (62.5%) cases were included. The main clinical outcome measures were graft survival, best corrected visual acuity (BCVA), endothelial cell density (ECD), corneal thickness (CT), and complications. Correlation of the anterior curvature changes with refractive error was analyzed in the DMEK with cataract surgery group. Results The overall survival rate was 71.9%. Final graft failures were caused by rejection, glaucoma, and infection. Visual acuities improved by 89.3%. BCVA better than 20/40 and 20/20 was found in 75% and 28.6% of patients, respectively. The ECDs at 3 months and 1 year were 1400 and 1083 cells/mm2, respectively. The mean survival time, ECD, BCVA, CT, and complication rates were not different between the endothelium-in and endothelium-out methods. A hyperopic shift by +0.42 D was not related to the anterior curvature changes. Conclusion Imported pre-cut tissues with a ≤ 3-day pre-cut-to-use time are feasible for DMEK in the treatment of corneal endothelial edema in eyes of Asian patients, and both endothelium-in and endothelium-out methods appear to be comparatively effective. Edema-induced anterior curvature change may not affect the refractive shift.
Histological and Bone Morphometric Evaluation of Osseointegration Aspects by Alkali Hydrothermally-Treated Implants

The purpose of this study was to investigate the osseointegration aspects of alkali-treated implants by histological and bone morphometric evaluations. Titanium implants (control) and alkali hydrothermally-treated titanium implants were used. Samples were evaluated by surface structure observation and wettability tests. Both implants were placed into the femurs of five rabbits, and osseointegration was assessed by measurement of removal torque (RT), bone–implant contact ratio (BIC), and bone tissue area ratio (BTA). Measurements were performed at the whole portion around the implant, the cortical bone portion, and the bone marrow portion. The surface structure of alkali-group showed nanoscale pores and super hydrophilicity. RT, BIC, and BTA values of alkali-group were significantly higher than those of control-group at the whole portion. In the cortical bone portion, the BIC value was higher in the alkali-group than in the control-group, and BTA showed no significant difference between groups. In the bone marrow portion, even though no significant difference between control and alkali groups, the latter had higher ratio of BIC than the former. These results indicate that alkali treated implants enhance bone integration in areas where the implant is in contact with bone, and may promote osteoinduction in the non-bone marrow portion.
Modified QuEChERS Method for Extracting Thiamethoxam and Imidacloprid from Stingless Bees: Development, Application, and Green Metrics

In the present study, a method for the determination of residues of the neonicotinoid insecticides thiamethoxam and imidacloprid in the stingless bee Melipona scutellaris Latreille (1811) was optimized through a factorial design, tested using green metrics, and then applied to exposed bees. It combines the extraction with a modified quick, easy, cheap, effective, rugged, and safe method and the determination by liquid chromatography–tandem mass spectrometry analysis. Different parameters such as the mass of the sample, dispersive sorbents, and elution solvents were assessed. Method validation parameters were checked and include sensitivity, specificity, and linearity. The limit of quantification of 0.0025 μg g–1 was obtained for both insecticides, where accuracy was 94%–100% with satisfactory intraday and interday precisions (relative standard deviation <10%). The qualified method was applied to orally and topically exposed bee samples, and the results indicated that it is suitable for the determination and quantification of neonicotinoid pesticide residues in this species. Moreover, green analytical metrics like the National Environmental Methods Index, Eco Scale score, high‐performance liquid chromatography with an environmental assessment tool (HPLC‐EAT), waste generation, and amount of sample were compared with methods described in the literature involving neonicotinoid analysis in honeybees. As a result, the present study displayed the highest Eco Scale score and HPLC‐EAT score and the second smallest amount of sample and waste generated. Thus, the method meets green analytical metrics more than other methods. In this sense, besides the application, the multicriteria decision analysis tool employed suggests that this is a good option as a green analytical method. Environ Toxicol Chem 2022;41:2365–2374. © 2022 SETAC
Risk factors for revision surgery due to dislocation within 1 year after 111,711 primary total hip arthroplasties from 2005 to 2019: a study from the Norwegian Arthroplasty Register

Background and purpose Dislocation of a hip prosthesis is the 3rd most frequent cause (after loosening and infection) for hip revision in Norway. Recently there has been a shift in surgical practice including preferred head size, surgical approach, articulation, and fixation. We explored factors associated with the risk of revision due to dislocation within 1 year and analyzed the impact of changes in surgical practice. Patients and methods 111,711 cases of primary total hip arthroplasty (THA) from the Norwegian Arthroplasty Register were included (2005–2019) after primary THA with either 28 mm, 32 mm, or 36 mm femoral heads, or dual-mobility articulations. A flexible parametric survival model was used to calculate hazard ratios for risk factors. Kaplan–Meier survival rates were calculated. Results There was an increased risk of revision due to dislocation with 28 mm femoral heads (HR 2.6, 95% CI 2.0–3.3) compared with 32 mm heads. Furthermore, there was a reduced risk of cemented fixation (HR 0.6, CI 0.5–0.8) and reverse hybrid (HR 0.6, CI 0.5–0.8) compared with uncemented. Also, both anterolateral (HR 0.5, CI 0.4–0.7) and lateral (HR 0.6, CI 0.5–0.7) approaches were associated with a reduced risk compared with the posterior approach. The time-period 2010–2014 had the lowest risk of revision due to dislocation. The trend during the study period was towards using larger head sizes, a posterior approach, and uncemented fixation for primary THA. Interpretation Patients with 28 mm head size, a posterior approach, or uncemented fixation had an increased risk of revision due to dislocation within 1 year after primary THA. The shift from lateral to posterior approach and more uncemented fixation was a plausible explanation for the increased risk of revision due to dislocation observed in the most recent time-period. The increased risk of revision due to dislocation was not fully compensated for by increasing femoral head size from 28 to 32 mm.
Is each horse unique and unrepeatable? An explanation through morphometric and statistical analysis of the limb bones

Horses went through functional differentiation during their evolutionary and reproductive development, however, some body parts continued to improve their specificity for speed. Regarding this, we evaluated by morphometric analysis the relationship between limb section (LS) differences in the appendicular structures of horses. Two hundred and seven (n = 207) adult horses of different breeds and sex were selected. The limb section was measured by identification of topographic palpable skeleton landmarks with a measurement tape (centimetres). Quantitative variables (limb section) were analysed with PAST Paleontological Statistics Version 3.16. Spearman's ordinal or non‐parametric correlation coefficient was used to study the relationship between the limb section of each variable (p < 0.05), with a low coefficient of variation (<30%). In 45 analysed correlations, 35 were statistically significant and 10 were discarded because p > 0.05. These results show that most variables were correlated with each other. As a result, we can imply that some LS of the horse's limbs are correlated with each other, positively or negatively and to a different degree. In conclusion, the correlations between LS lengths determine the size and shape of each horse, making individual horses unique and unrepeatable.
[Prevalence and factors associated with high blood pressure, awareness, and treatment among elderly in Southern Brazil].

The aim of this study was to describe prevalence, awareness, and treatment of high blood pressure (HBP) and associated factors among the elderly in Florianopolis, Santa Catarina State, Brazil. This cross-sectional population-based study used a complex sampling design. HBP was defined as elevated blood pressure (by direct measurement), use of antihypertensive medication, or prior diagnosis. The association of outcomes with independent variables was assessed by Poisson regression. One-thousand seven hundred and five participants were interviewed. Of these, 84.6% presented HBP, 77.5% were aware of their condition, and 79.1% were on antihypertensive medication. Prevalence of HBP was associated with age, functional capacity, and body mass index (BMI). Awareness of the condition was associated with age, gender, BMI, self-rated health, and recent medical consultation. Treatment was associated with gender, functional capacity, self-rated health, and recent medical consultation. Although public health policies should include everyone, unequal distribution of HBP in the population should be addressed through targeted preventive, diagnostic, and therapeutic measures.
Mycobacterium tuberculosis on the evolution of marinum Mycobacterium Insights from the complete genome sequence of Material Supplemental

Open Access Freely available online through the Genome Research Open Access option. service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the Correction http://genome.cshlp. org/content/18/10/1680.full. html online at: been appended to the original article in this reprint. The correction is also available have correction A correction has been published for this article. The contents of the
Effects of etching process and annealing temperature on the ferroelectric properties of atomic layer deposited Al-doped HfO2 thin film

An investigation was conducted with regard to the effect of etching process on the ferroelectric (FE) characteristics of different device structures with Al-doped HfO2 thin films; further, the effect of the rapid thermal annealing temperature on the FE properties was elucidated using metal-ferroelectric-metal (MFM) capacitors using TiN electrodes with varying thickness and 4 at. % Al-doped HfO2 FE layer. The capacitors were annealed at different temperatures after lithography and etching process; this was aimed at incorporating the FE-orthorhombic phase. The samples annealed after patterning were able to obtain improved FE characteristics due to the amount of tensile stress. The MFM devices that were initially patterned were also studied as a reference. We found that even though it required higher temperature and shorter time to introduce the FE phase, it exhibited more stable as well as promising FE properties and electrical performances with a relatively large remnant polarization (2P r ∼ 60 μC cm−2), a coercive electric field of approximately 2 MV cm−1 and high switching current density with less leakage. Our results indicate how the FE properties of the HfO2-based thin films can be engineered through suitable process sequence and post-annealing conditions, thereby verifying the applicable flexibility of FE-HfO2 for semiconductor device integration.
Cortico-cerebellar audio-motor regions coordinate self and other in musical joint action

Abstract Joint music performance requires flexible sensorimotor coordination between self and other. Cognitive and sensory parameters of joint action—such as shared knowledge or temporal (a)synchrony—influence this coordination by shifting the balance between self-other segregation and integration. To investigate the neural bases of these parameters and their interaction during joint action, we asked pianists to play on an MR-compatible piano, in duet with a partner outside of the scanner room. Motor knowledge of the partner’s musical part and the temporal compatibility of the partner’s action feedback were manipulated. First, we found stronger activity and functional connectivity within cortico-cerebellar audio-motor networks when pianists had practiced their partner’s part before. This indicates that they simulated and anticipated the auditory feedback of the partner by virtue of an internal model. Second, we observed stronger cerebellar activity and reduced behavioral adaptation when pianists encountered subtle asynchronies between these model-based anticipations and the perceived sensory outcome of (familiar) partner actions, indicating a shift towards self-other segregation. These combined findings demonstrate that cortico-cerebellar audio-motor networks link motor knowledge and other-produced sounds depending on cognitive and sensory factors of the joint performance, and play a crucial role in balancing self-other integration and segregation.
On the Plasma Temperature in the Hybrid Plasma-MIG Welding Process

In many respects, the advantages of the hybrid welding process Plasma-MIG are explained by the interaction of the arc discharges, which make up it: a plasma discharge and an arc with a consumable electrode (MIG). Knowledge and understanding of the laws of this interaction is very important for the implementation of the process and obtaining good results. The theoretical analysis of the influence of the plasma discharge temperature with non-consumable electrode on the melting of the electrode wire was carried out. The dynamics of the melting of the electrode wire and dynamics of circuit with consumable electrode arc were been investigation. Estimates of the maximum value of the temperature of plasma discharge have been made. These results were used to select welding modes and for carrying out the technological experiments.
Topiramate for Weight Management in Children with Severe Obesity.

Background: Topiramate has been shown to result in significant weight loss compared to placebo in adults with obesity. However, there are no consensus guidelines on the acceptability, safety, and efficacy of topiramate for weight loss in children. We present a literature review and case series on topiramate use in young children with severe obesity. Methods: We performed a PubMed search from January 2000 to February 2022 utilizing keywords, "topiramate" and "obesity" and "children" and "adolescent. " For our case series, children were identified through retrospective chart review from a multidisciplinary weight management program. Eligibility criteria: age ≤12 years, class II or III obesity, completed 16 weeks of topiramate therapy as adjunct to lifestyle modifications. Semistructured interviews were conducted with one parent to review side effects. Results: Literature search yielded nine articles. All studies reported trends toward BMI reduction and weight loss with topiramate monotherapy. Five children met case series eligibility (mean age 10 years 3 months ±1.5 years, 60% female). After 16 weeks of topiramate, all children had a decrease in BMI as a percentage of the 95th percentile (mean -12% [-5% to -18%]). Parents reported improvement in impulsive eating and decreased desire to overeat compared to baseline. Four out of five reported no side effects, one reported drowsiness which resolved by dosing at nighttime. Conclusions: Results suggest that topiramate is well tolerated and may be utilized for weight management in younger children. A randomized controlled trial investigating the impact of topiramate for weight management in this age group is warranted.
Epidemiological features, risk factors and disease burden of respiratory viruses among hospitalized children with acute respiratory tract infections in Xiamen, China.

Well-established surveillance and monitoring system for respiratory viruses need be improved and epidemiological data about respiratory viruses is scarce in China. This study aimed to investigate epidemiological characteristics of respiratory viruses among hospitalized children ≤ 2 years old with acute respiratory tract infections (ARTIs) in Xiamen, China from October 2014 to September 2017. The clinical records of 7248 children hospitalized for ARTIs were analyzed retrospectively. Respiratory syncytial virus (RSV) (22.3%) was the most common virus among hospitalized children ≤ 2 years old, followed by parainfluenza (5.0%), adenovirus (3.5%) and influenza (1.7%). RSV-infected children possessed a higher disease burden including higher ICU admission rate (12.7%) and hospital charges ($635.36). Especially, infants < 6 months of age had the highest risk of RSV infection (OR= 2.4, 95% CI: 1.9-2.9) and higher ICU admission rate (12.1% vs. 4.5%, 4.6%) and hospital costs ($923.3 vs. $785.5, $811.7) than other age groups. Therefore, infants aged 0-6 months, especially premature infants and children with congenital diseases, should receive more concern. There is an urgent need to develop effective immunization strategies to protect these infants through the first 6 months of life or RSV season.
Abnormal functional connectivities patterns of multidomain cognitive impairments in pontine stroke patients

Cognitive dysfunction in patients with infratentorial stroke has been paid little attention. Brainstem stroke may disrupt network connectivity across the whole brain and affect multidomain cognition, but the details of this process remain unclear. The study aimed to investigate the effects of stroke‐induced pontine injury on whole‐brain network connectivity and cognitive function. We included 47 patients with pontine stroke and 56 healthy comparisons (HC), who underwent cognitive tests and functional magnetic resonance imaging (fMRI). Seven meaningful brain networks were identified using independent component analysis (ICA). Patients with pontine stroke had decreased intra‐network functional connectivities (FCs) in the primary perceptual and higher cognitive control networks, including sensorimotor network (SMN), visual network (VIS), default mode network (DMN), and salience network (SAN), as well as decreased inter‐network FCs in the primary perceptual (VIS‐SMN) and higher cognitive control networks (bilateral frontoparietal networks, rFPN‐lFPN). While the FCs between the primary perceptual and higher cognitive control networks (VIS‐DMN, VIS‐rFPN, VIS‐lFPN) were increased. Furthermore, the alterations in these FCs correlated with patients' cognitive measurements. These findings suggested that the infratentorial stroke can induce dysfunctional connectivity in both primary perceptual and higher cognitive control networks at the whole‐brain level, which may be attributable to the neural substrates of multidomain cognitive deficits in these patients.
Evaluating the socio-demographic, economic and clinical (SDEC) factors on health related quality of life (HRQoL) of hypertensive patients using EQ-5D-5L scoring algorithm

This study was conducted to determine the various socio-demographic, economic, and clinical variables (SDECVs) which influence the health-related quality of life (HRQoL) of hypertensive patients. Three hundred and fifty hypertensive patients participated in this study through a structured questionnaire and EQ 5D 5L. 211(60.28%) participants had stage 1, and 139 (39.7%) had stage 2 hypertension. No participants reported severe problems in any domain on EQ 5D 5L. Generalize Linear Model (GLM) was used to assess the association between HRQoL and SDECVs. The mean utility and VAS score was 0.64 (±0.15) and 63.17 (±11.01) respectively. The participants of the stage 1 hypertension group had a significantly better score on each domain of EQ 5D 5L as compared to stage 1 (0.027, 0.010, 0.00, 0.00, 0.048). No participant in either group reported extreme problems in any domain. Among socio-demographic factors, the males, non-smokers, income sharing, and healthy normal hypertensive patients had better HRQoL (0.009, 0.016, 0.019, and 0.003). A lower cost of treatment was also associated with better HRQoL (0.017). Among clinical variables, stage 1 hypertension had better HRQoL than stage 2(0.035). The number of prescribed antihypertensive drugs had no effect on the quality of life (0.253), however, the non-pharmacologic interventions such as reduction in salt and oil consumption (0.035), reduction in beverages consumption (0.0014) and increased water intake (0.010) had resulted in better QoL. The patients who reported dizziness had poor HRQoL while patients who had cardiac problems and diabetes reported a significantly lower EQ-VAS score. The effect of gender on the HRQoL of hypertensive patients who had comorbid conditions was significant in the case of renal, respiratory, visual problems, and dizziness where females had a lesser utility score than males. The study reports on significant determinants which should be taken into account in an attempt to improve the health-related quality of life of hypertensive patients.
5G system design : architectural and functional considerations and long term research

This book provides a comprehensive overview of the latest research and standardization progress towards the 5th generation (5G) of mobile communications technology and beyond. It covers a wide range of topics from 5G use cases and their requirements, to spectrum, 5G end-to-end (E2E) system architecture including core network (CN), transport network (TN) and radio access network (RAN) architecture, network slicing, security and network management. It further dives into the detailed functional design and the evaluation of different 5G concepts, and provides details on planned trials and pre-commercial deployments across the globe. While the book naturally captures the latest agreements in 3 rd Generation Partnership Project (3GPP) New Radio (NR) Release 15, it goes significantly beyond this by describing the likely developments towards the final 5G system that will ultimately utilize a wide range of spectrum bands, address all envisioned 5G use cases, and meet or exceed the International Mobile Telecommunications (IMT) requirements for the year 2020 and beyond (IMT-2020).