Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone marrow-derived stem cell therapy in acute myocardial infarction : an experimental porcine model

Stem cell therapy has several mechanisms for repairing damaged myocardium and improving functional capacity of the left ventricle reduced by myocardial infarction. Despite the increase in scientific data, details of these mechanisms are still partly unexplained. The optimal number and type of stem cells as well as timing and route of transplantation are unclear. The purpose of this study was to clarify therapeutic potential of bone marrow-derived stem cells (BM-MNCs) using experimental porcine acute myocardial infarction model. Myocardial infarction was caused by occluding the circumflex coronary artery for 90 minutes. Immediately after reperfusion BMMNCs were injected directly into the damaged myocardium or by angioplastic catheter into the infarct-related coronary artery. Left ventricular ejection fraction (LVEF) improved 3 weeks after infarction in animals that received BM-MNCs intramyocardially whereas in animals that received intracoronary transplantation or saline LVEF failed to recover. Radionuclide imaging and histological analysis showed intramyocardially transplanted cells remaining in the infarcted myocardium, whereas after intracoronary transplantation a major fraction of cells flushed into the lungs. In histological analysis minor fraction of BM-MNCs showed differentiation towards myocyte form and proliferation. Significantly lower collagen density and higher levels of smooth muscle actin and skeletal muscle actin were detected in the infarcted myocardium after intramyocardial or intracoronary BM-MNC transplantation compared with animals that received saline. Proteomic screening indicated that mitochondrial energy metabolism recovered after BM-MNC transplantation. Additionally, two proteins showed elevated levels after BM-MNC transplantation, which indicates that they are actively involved in the pathological mechanisms. BM-MNCs appear to enhance recovery of the infarcted myocardium by restoring the reduced LVEF after infarction. Intramyocardial stem cell therapy showed best results in recovery. Stem cell therapy moulds the infarct scar by reducing collagen density and by increasing components typical for muscle cells. The effects of stem cell therapy are mainly paracrine.
Análise das Variáveis Hemodinâmicas em Idosos Revascularizados após Mobilização Precoce no Leito Analysis of Hemodynamic Variables among Elderly Revascularized Patients after Early In-Bed Mobilization

Background: During the post-operative phase after coronary artery bypass (CAB) surgery, prolonged bed rest increases the possibility of systemic complications resulting from immobilization. Objective: To ascertain the behavior of peak expiratory flow and hemodynamic variables among elderly patients during the CAB postoperative period undergoing three types of physiotherapy interventions. Methods: Thirty elderly patients were studied, divided into three groups: Group A - mobilization with an ergometric bicycle; Group B - mobilization without an ergometric bicycle but with physiotherapy; and Group C - no mobilization but with non-invasive ventilation, analyzing the heart rate (HR), respiration rate (RR), blood pressure (BP), peripheral oxygen saturation (SpO 2 ) and expiratory peak flow. The Wilcoxon test was used for variations in the intra-group results for the pre- and post-test phases, using the Kruskal-Wallis test for the inter-group comparison of the pre and post-test phases, with a statistical significance of p<0.05. Results: A significant increase was observed in the peak flow values for the three groups (pre- and post-test); with a significant reduction in the systolic blood pressure for group A and higher heart rates and respiration rates in group B. The inter-group analysis presented a statistically significant reduction in the diastolic blood pressure for group C.
9-(4-Hydroxy-3,5-dimethoxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

In the title compound, C25H30O6, the two fused cyclohexanone rings have envelope conformations, whereas the central pyran ring is roughly planar [mximum deviation = 0.045 (2) Å]. The pyran and benzene rings are almost perpendicular to each other, making a dihedral angle of 86.32 (2)°. In the crystal, molecules are linked via pairs of O—H⋯O hydrogen bonds, forming inversion dimers.
Effects of interferon-β on co-signaling molecules: upregulation of CD40, CD86 and PD-L2 on monocytes in relation to clinical response to interferon-β treatment in patients with multiple sclerosis

Interferon-beta (IFN-β) reduces disease activity in a subgroup of patients with relapsing remitting multiple sclerosis (MS). The mechanism of action as well as the pathophysiological basis of responsiveness to IFN-β is not well understood. Since T-cell activation plays an important part in the pathophysiology of MS, we here investigated the effect of IFN-β on the expression of co-signaling pathways (CD28—CD80/CD86, CD154—CD40, ICOS—ICOSL, PD-1—PD-L1/2) in MS patients and correlated the results with the clinical response to IFN-β in individual patients. Expression of co-signaling molecules was measured by flow cytometry in vitro on peripheral blood mononuclear cells after incubation with IFN-β, and in vivo in whole blood samples of 32 untreated and 24 IFN-β treated MS patients, including 13 patients longitudinal. IFN-β treatment induced upregulation of CD40, CD80, CD86, PD-L1 and PD-L2 on monocytes as well as PD-L1 on CD4+-T-cells in vitro and in vivo. IFN-β treated MS patients were grouped into responders and non-responders on the basis of Kurtzkés EDSS (expanded disability status scale) progression and relapse rate. Upregulation of CD40, CD86 and PD-L2 on monocytes was associated with treatment response to IFN-β (P < 0.001, P = 0.028 and P = 0.028, respectively). Our results show that IFN-β upregulates co-stimulatory as well as co-inhibitory molecules in vitro and in vivo implicating that modulation of the balance between positive and negative co-stimulatory signals might be an important part of the mechanism of action of IFN-β in MS. Upregulation of the expression of CD40, CD86 and PD-L2 may be useful as a predictive marker for clinical response to IFN-β treatment at early timepoints during IFN-β therapy. Multiple Sclerosis 2008; 14: 166—176. http://msj.sagepub. com
Maternal mortality surveillance system: attitude of health care staff and experts

هديكچ ردام گرم نا ي ک ي مهم زا رت ي صخاش ن اه ي م رامش هب عماوج هعسوت ي دور . ا روشک رد ي ردام گرم تبقارم ماظن نار ي لاس زا ۱۳۸۰ زاـغآ تسا هدومن راک هب . ا رد ي سم ماظن ن ي ر ي ط گرم نامز ات ردام ره هک ي اـسانش بانتجا لباق لماوع ،هدش فشک ،تسا هدرک يي ارـبو ي اـهنآ حارط هلخادم ي م ارجا و ي دوش . ا ي ن هعلاطم شخب ود رد يفيك و يمك ماجنا ش د : رد مک شخب ،ي شرگن ۱۰۴ زا نت داتس نانکراک ي همانشسرپ قيرط زا رد و ک شخب ي ف ،ي تارظن ۶ زا رفن س و نارگشهوژپ ي رد نارازگتسا ارجا فعض طاقن دروم ي ردام گرم تبقارم ماظن قيمع هبحاصم قيرط زا ي تفرگ رارق يسررب دروم . ن يمك شخب جياتن هك داد ناش ب ي رتش ي ن دصرد نانکراک رد دروم ره ٣ هلحرم عمج روآ ي ،تاعلاطا ـحارط ي هـلخادم و ارـجا ي هـلخادم شرگن تبسن ً ا بولطم دنتشاد . مدـع ،اـهنآ يدـنب عـمج ندوـب لكـشم و راوناخ و يفوتم يتيعمج تاعلاطا دروم رد شسرپ ندوب بسانمان هدر بسانم كيكفت دنمزاين ينامرد رداك فلتخم ياه توف لحم زين و شزومآ هب ) تاعلاطا يروآ عمج هلحرم رد ( هـتيمك يرازـگرب ، هـب اـه يتافيرشت تروص ) هلخادم يحارط هلحرم رد ( اهنآ حيحص يارجا مدع اي تلاخادم يحارط مدع زين و ) هـلخادم يارجا هلحرم رد ( فعـض دراوـم زا دوب نارازگ تسايس و نارگشهوژپ طسوت يفيك شخب رد هدش هراشا .
Evaluation of the Effectiveness of Different Teaching Methods on Anxiety in Patients Referred for Endoscopy

Background : Gastrointestinal disorders are common complaints for which endoscopy is one of the most important diagnostic procedures. Anxiety is an unpleasant, ambiguous feeling of apprehension and fear of an unknown origin that occurs during anxious and previously stressful situations or during an injury. Lack of sufficient information and fear of pain can cause anxiety prior to an endoscopy, reducing the trend of patients and increasing the endoscopy time. This study aims to evaluate the effectiveness of various teaching methods (oral, written, oral-written) on patient anxiety prior to an endoscopy. Materials and Methods: This was a case-control study that enrolled 100 patients, 18-80 years of age, who had at least reading and writing literacy. Patients who referred to a specialized clinic at Tabriz University of Medical Sciences for their first endoscopy between December to March 2011 were selected. We randomly divided patients into four groups (oral, written, oralwritten teaching, and control) after their first anxiety assessment with the Beck questionnaire. The information was given to patients by the investigator using the training packages. The next day, 30 minutes prior to the endoscopy, patients completed another Beck Anxiety questionnaire and the effectiveness of the different methods was evaluated. Results: Mean anxiety scores decreased in all three teaching groups after intervention, which was statistically significant compared with the control group ( p p Conclusion: The provision of adequate information to patients about the endoscopy procedure, independent of the teaching method, can reduce patient anxiety.
Effects of Unilateral Cryptorchidism on Contralateral Epididymal Sperm Quality, Quantity and Fertilizing Capacity

The effect of unilateral cryptorchidism on ipsilateral testicular function has been well studied both in human and experimental animals. However, the effect of unilateral cryptorchidism on contralateral testicular function remains unclear. To evaluate the effect of left cryptorchidism on right testicular function, 3 groups of immature male rats were used: group A, left cryptorchid rats; group B, sham operated rats and group C, orchidopexed rats. Ten weeks post-cryptorchidism induction, right testicular versus intraabdominal temperature difference (RΔT), bilateral epididymal sperm content and motility, bilateral testicular weight, fertility rate in vivo and in vitro, and serum testosterone responses to human chorionic gonadotropin stimulation were tested. Most of the above parameters were significantly lower in group A than in group B and significantly higher in group C than in group A. The current findings suggest that there is a detrimental effect of unilateral cryptorchidism on sperm fertilizing capacity in vitro not only on the ipsilateral side but also on the contralateral side.
Bis{2-ethoxy-6-[2-(isopropylammonio)ethyliminomethyl]phenolato}dithiocyanatonickel(II)

In the mononuclear title complex, [Ni(NCS)2(C14H22N2O2)2], the Ni atom lies on an inversion centre. It is chelated by the phenolate O and imine N atoms from two zwitterionic Schiff base ligands, and is also coordinated by the N atoms from two thiocyanate ligands, giving a slightly distorted octahedral geometry. Intramolecular N—H⋯O and N—H⋯N hydrogen bonds are observed.
Ketofol Infusion as a Procedural Sedation and Analgesia Modality for Minor Orthopedic Surgeries: Evaluation of Dose-Outcome Relation

Objectives: To evaluate dose-outcome relation of ketofol procedural sedation and analgesia (PSA) used for minor orthopedic surgeries. Patients & Methods: 90 patients attended the emergency department (ED) with distal end of radius fracture required closed reduction and slab fixation without the need for open surgical interference and were randomly allocated into 3 equal (n=30) study groups assigned to receive sedation solution using propofol (0.5 mg/kg/hr) and ketamine (0.5 mg/kg/hr) infusion mixture in 1:1 ratio (Group A), 2:1 ratio (Group B), and 3:1 ratio (Group C). All patients were monitored non-invasively for arterial blood pressure, heart rate, oxygen saturation, and respiratory rate; sedation scoring according to the Observer Assessment of Alertness/Sedation (OAA/S) scale and postoperative (PO) pain was judged using a 0-100 visual analogue pain scale (VAS). PO duration of hospital stay and the frequency of PO side effects were reported and patients' satisfaction was assessed using a 4-point verbal rating scale. Results: Surgical procedure was completed successfully with minor hemodynamic changes (52.5%) and spared PO analgesia in about 40% of patients. Significantly more hemodynamic stability and less frequency of respiratory depression was reported in group A compared to group C. Patients received 1:1 infusion had significantly lower sedation scores, sedation duration and shorter duration of PO stay and total duration of hospital stay compared to groups B and C with significant difference in favor of group B. However, patients received 1:1 infusion experienced significantly higher VAS pain scores with non-significantly higher consumption of rescue analgesia compared to groups B and C. Patients received 2:1 ketofol infusion reported significantly higher satisfaction about both sedation and analgesia compared to groups A and C with significantly higher satisfaction in favor of group A. PO nausea and vomiting occurred in 13 patients (14.4%) and over-sedation in 10 patients (11.1%) with non-significant difference among studied groups despite being in favor of group A. No psychomotor or behavioral sequlae were reported with the used dose of ketamine. Conclusion : Ketofol infusion in 2:1 ratio could be considered the appropriate PSA modality for minor orthopedic surgeries providing short PO and total hospital stay with minor hemodynamic changes and PO side effects and acceptable levels of both PO analgesia and sedation.
1,2-Bis(N′-benzoylthioureido)benzene

The title compound, C22H18N4O2S2, was characterized by 1H and 13C NMR, solid-state IR spectroscopy and X-ray crystallographic techniques. The crystal structure determination reveals that the twisting modes of the two side arms are different [C—N—C—O and C—N—C—N torsion angles = −1.2 (3) and 1.1 (3)°, respectively, in one arm and 24.1 (3) and −5.1 (3)°, respectively, in the other]. The crystal structure involves N—H⋯O and N—H⋯S hydrogen bonds.
2-Chloro-N-(3-chlorophenyl)acetamide

The N—H bond in the title compound, C8H7Cl2NO, is anti to the meta-chloro substituent in the aromatic ring in both independent molecules comprising the asymmetric unit. The C=O bond is anti to the N—H bond and is also anti to the methylene H atoms. Intermolecular N—H⋯O hydrogen bonds link the molecules into supramolecular chains.
4,5-Bis(4-methoxyphenoxy)phthalonitrile

The title compound, C22H16N2O4, was obtained unintentionally as the product of an attempted synthesis of a new phthalocyanine. The dihedral angles formed by the central benzene ring with the aromatic rings of the methoxyphenoxy groups are 85.39 (5) and 64.19 (5)°.
(Acetato-κO)(acetato-κO,O′)bis(1,3-diazinane-2-thione-κS)cadmium(II)

In the title complex, [Cd(CH3COO)2(C4H8N2S)2], the CdII cation is coordinated by three acetate O atoms and two S atoms of Diaz [Diaz = 1,3-diazinane-2-thione = 3,4,5,6-tetrahydropyrimidine-2(1H)-thione]. The CdII coordination is augmented by one considerably longer Cd—O bond of 2.782 (3) Å to a carboxylate O atom. The resulting coordination polyhedron around the CdII cations can be described as a highly distorted octahedron. The Diaz ligand and the acetate anions are linked by N—H⋯O hydrogen-bonding interactions.
Interpreting recent measurements of0+states in158Gd

states, and hence E1orE3 tran-sition rates, is schematic only. Nevertheless, the results high-light the importance of including the octupole degree of free-dom if one is studying deformed nuclei above the pairinggap. We interpret these results as being an existence proof~rather than quantitative predictions! that models including
Effectiveness of Liv.52 against Radiation Sickness and Dermatitis

Radiation sickness and dermatitis were studied in two groups of adult Swiss albino mice after whole-body exposure to 3 different doses (8.0, 9.0 or 10.0 Gy) or Co Gamma radiation in the presence and absence of Liv.52 and results from both the groups were compared. It was found that the symptoms of sickness, which were noticed in the control animals, were not present in the experimental group. In the former the epithelium showed hyperplasia and atypical changes in the cells. The skin appendages were also completely absent. However, in the Liv.52 treated animals the epithelial structure was normal and skin appendages were preserved.
The Influence of Exercise Characteristics Before and During Pregnancy on Gestational Diabetes Mellitus

Background: Although exercise is recommended for preventing gestational diabetes mellitus (GDM), the situation has remained unclear regarding the characteristics and timing of the proper exercise. Objectives: The aim of the present study was to compare exercise characteristics including volume, frequency, intensity and energy expenditure before and during pregnancy in diabetic and non-diabetic pregnant women. Patients and Methods: Participants of the study included 137 pregnant women (80 diabetics and 57 non-diabetics) who were selected based on the inclusion criteria. Exercise activities of the participants were evaluated by interviews. Statistical tests of Mann-Whitney and Chi-square were used for data analysis. Results: Participating in regular exercise activities was significantly higher in the non-diabetics compared to the diabetics during all stages including 8 and 1 years before pregnancy and during the 1st and 2nd trimesters of pregnancy (P < 0.05). However among the diabetics and non-diabetics who regularly exercised, there was no significant difference in terms of exercise characteristics (frequency, intensity, duration and energy cost). Conclusions: Regular participation in exercise activities before and during pregnancy especially during the second trimester is important for preventing GDM. However, in few cases, similar exercise characteristics were found among diabetics and non-diabetics.
(4Z,6Z)-4,6-Bis(4-methoxybenzylidene)-2,2-dimethyl-1,3-dioxan-5-one

The title compound, C22H22O5, crystallizes with two independent molecules in the asymmetric unit, both of which possess pseudo-C s symmetry. The central 1,3-dioxanone rings have envelope conformations, with the C atom bearing the two methyl groups at the flap. The benzene rings of the methoxybenzylidene units, attached in the 4- and 6-positions on the central 1,3-dioxanone rings, are tilted in the same direction with dihedral angles varying between 8.2 (1) and 18.1 (1)°. The crystal packing is influenced by π-stacking interactions of the parallel displaced type [centroid–centroid distance of 3.723 (1) Å for molecule 1 and 3.884 (1) Å for molecule 2, with ring slippages of 1.432 and 1.613 Å, respectively] and the T-shaped type, with the long molecular axes all aligned along [010].
1-(4-Bromophenyl)-3-(3,4-dimethylphenyl)prop-2-en-1-one

In the title chalcone derivative, C17H15BrO, the dihedral angle between the two benzene rings is 48.13 (4)°. In the crystal, a short Br⋯Br contact of 3.5052 (10) Å occurs.
1-Ethoxy-2-methoxy-4-[2-(4-nitrophenyl)ethenyl]benzene

In the title molecule, C17H17NO4, the dihedral angle between the two aromatic rings is 42.47 (7)°. The nitro group is twisted by 7.44 (11)° out of the plane of the ring to which it is attached. The methoxy and ethoxy group O atoms deviate significantly from the phenyl ring [by 0.0108 (11) and 0.0449 (11) Å, respectively]. The crystal structure is stabilized by C—H⋯π interactions.
Burn-In

Burn-In is used to screen weak parts from a population of completely processed chips to assist in meeting reliability requirements. This tutorial provides a general introduction to burn-in. It is shown how burn-in improves the failure rate. Typical burn-in conditions, the burn-in models and an example of failure mechanisms are given. The impact of burn-in on technology reliability (hot carriers, gate oxide, electromigration) is discussed, emphasizing that the upper limits of the burn-in conditions can be controlled by technology reliability. Finally the benefits and disadvantages of burn-in are summarized.
3-[3-(4-Bromophenyl)-1-phenyl-1H-pyrazol-4-yl]-5-ethoxy-2-phenylisoxazolidine

In the title compound, C26H24BrN3O2, the isoxazolidine ring adopts an envelope conformation, the ring N atom deviating from the mean plane of the other four atoms by an angle of 0.286°. The orientation of the phenyl ring is +sp and the bromophenyl ring is +sc relative to the attached pyrazole ring; the dihedral angles between the least-squares planes of the pyrazole and the attached phenyl and bromophenyl rings are 21.8 (3) and 41.8 (3)°.
Diaquabis(nitrato-κO)bis(pyridine-κN)manganese(II)

The structure of the title manganese complex, [Mn(NO3)2(C5H5N)2(H2O)2], consists of discrete monomeric entities with Mn2+ ions located on centres of inversion. The metal cation is octahedrally coordinated by a trans-N2O4 donor set with the pyridine N atoms located in the apical positions. Discrete molecules are linked by O—H⋯O hydrogen bonds into one-dimensional supramolecular infinite chains along the b and c axes.
4-({4-[Bis(2-cyanoethyl)amino]phenyl}diazenyl)benzenesulfonamide

In the title compound, C18H16N6O2S, which belongs to the family of azo dyes, the dihedral angle between the benzene rings is 26.16 (7)°. In the crystal, molecules are joined by N—H⋯N and C—H⋯N hydrogen bonds into double chains parallel to the a axis.
Comparing the effects of chlorhexidine solution with or without toothbrushing on the development of ventilator-associated pneumonia among patients in ICUs: a single-blind, randomized controlled clinical trial

Background & Aim: Poor oral care for the ventilated patients in intensive care units (ICU) can result in the accumulation of pathogens and respiratory infections. In this regard, in addition to the chemical methods, a mechanical method has been recommended to be added. However, concerning its effect on pneumonia, different findings have been reported. Therefore, this study was conducted to compare the effects of chlorhexidine solution with or without toothbrushing on the development of ventilator-associated pneumonia among patients in ICUs. Methods & Materials: This was a single-blind, randomized controlled clinical trial conducted in two selected hospitals of Ahvaz city in 2014. A convenience sample of 68 ventilated patients was randomly allocated to the toothbrush group (34 patients) or the gauze swab group (34 patients) using R software. Both groups received 0.2 Chlorhexidine solution. The intervention was performed in both groups for 3 minutes twice a day for five days. At the end of the fifth day, the development of pneumonia was assessed using the Clinical Pulmonary Infection Score (CPIS). Data were analyzed by Chi-square and t-independent test through SPSS v.16. Results: The two groups were similar for age, sex, cause of admission, level of consciousness, medication and tobacco use. The majority of patients (58.8) were diagnosed with pneumonia (Group A: 55.9 and Group B: 61.8). The Chi-square test showed no significant difference between the two groups for the development of pneumonia (P>0.05). Conclusion: The use of Chlorhexidine solution with toothbrushing compared to using Chlorhexidine with swab could not reduce the development of pneumonia. However, due to its importance, further research is needed in this regard. © 2015, Tehran University of Medical Sciences (TUMS). All rights reserved.