Miracle-dz/UniFAR-FTUs huggingface dataset:
The first cut is the deepest: changing clinical practice for ALK-positive lung cancer

Approximately 4% of non-small-cell lung cancers (NSCLC), mostly adenocarcinomas, harbor oncogenic ALK gene fusions. Patients with such ALK-positive NSCLC tend to be younger, more frequently female and more frequently non-smokers (1,2). Based on superiority to chemotherapy two ALK-tyrosine kinase inhibitors crizotinib (3) and ceritinib (4) were approved for first-line therapy. Hence, both ESMO (5) and CAP (6) guidelines require screening of all NSCLC for ALK fusions, except pure squamous cell carcinomas from heavy smokers. As rapid and cost-effective screening by IHC followed by either by FISH or hybrid capture sequencing has been established, even in patients presenting with very advanced disease and urgent need for therapy first line therapies are possible and effective (7). An illustrative case is shown in Figure 1 and presented in detail previously (7).
Susceptibility Of Pseudomonas Aeruginosa To Newer Cephalosporins

Seventy strains of pseudomonas aeruginosa isolated form clinical samples of hospital-infected cases were tested for sensitivity to cerftazidime, cefotaxime and cephazoline. Five strains (7%) were resistant to ceftazidime, 28 (40%) to cerfotaxime and 56 (80%) to cephazoline, MIC of ceftazidime for the resistant strains was 4.0 mg/L, whereas the sensitive strains were inhibited by 0.5-1.0 mg/L of the drug. Thirty four percent of the strains were betalacamase producers. In vitro cephalosporin resistance was compared to that of aminoglycosides viz. gentamicin (39%), sisomicin (57%) and tobramycin (45%).
Red cell genotyping in Thailand: trends for blood transfusion in Asian populations

Numerous molecular techniques have been employed to determine well‐matched blood units for patients in need, particularly those requiring blood transfusions within 3 months and presenting positive DAT results. Only specialized reference laboratories use commercially available kits for red cell (RC) genotyping due to their expense and requiring extremely sophisticated instruments. Moreover, regarding complicated cases, particular typing reagents may be unavailable or insufficient. Therefore, identifying and confirming the compatibility of the blood units donated would require more time. This article aims to review the present uses of RC genotyping in Thailand and their significant contributions to transfusion practices in Asian populations. RC genotyping using PCR‐sequence‐specific primer (PCR‐SSP) and multiplex PCR (M‐PCR) has been established and used in patient and donor populations. The results of genotyping acquired by PCR‐SSP and M‐PCR were precise and in agreement with serological techniques. Predicted phenotypes of clinically significant blood group systems have been used to determine the compatibility of RC units among Thai patients having multiple antibodies. As a result, one additional advantage is the expanded storing of donated, frozen rare blood types. RC genotyping for high‐ and low‐prevalence antigens among differing Asian ethnicities requires consideration. RC genotyping employing these advanced PCR techniques could provide testing results that are both reliable and appropriate to screen suitable donor blood units in complex cases or patients presenting rare blood types. In addition, comparable strategies could be employed in other Asian populations using limited resources.
Comparação de métodos diretos de extração e quantificação dos teores de clorofilas em folhas do capim-Tifton 85

This study aimed to assess which is the most appropriate protocol for extraction of chlorophylls a, b and total (a + b) to be applied in studies with Tifton 85 (Cynodon spp.) forage grass. Results revealed that, based on total (a + b) chlorophyll contents, the best extractors were N,N-dimethylformamide, dimethylsulfoxide and acetone 80% (using the equations proposed by ARNON, 1949). Temporal changes in the concentrations of chlorophyll a, b and total were well described by a hyperbolic model common to all solvents, being the period of 48 hours considered sufficient for an appropriate extraction.
Modeling Design and Management of Residential Community for Enhancing Elderly Well-Being in Thai Cultural and Spiritual Environments

This research presents factors related to the environmental perceptions, the residential community,and the design of spiritual and healing environments, which effect the elderly Thai population. Theresearch revealed that their needs were identified as 1) the requirements of general facilities and activities,2) requirements of facilities related to health and security, and 3) the requirements of facilities related tophysical exercise. The results show that the characteristics of the elderly have a direct effect on a varietyof requirements needed in the residential community. From observing and interviewing three case studies,the concept of the spiritual environment was necessary for the elderly Thais. The result led to formulatingappropriate policies in design and management of the residential community to enhance the quality of life,both physically and mentally, of elderly Thais.
Student evaluation of teaching : can it raise attainment in secondary schools? : a cluster randomised controlled trial

The effectiveness of teaching is cited as one of the most significant actors on students’ learning (Centra, 1993; Creemers, 1994; Marsh, Nagengast, Fletcher, & Televantou, 2011), yet the measurement of it is an imperfect and problematic activity, not least due to the lack of consensus over a definition of effective teaching and, consequently, no consistently-used measurement instrument(s) designed for the purpose (Chingos & Peterson, 2011; Goldhaber & Anthony, 2004; Kane, McCaffrey, Miller, & Staiger, 2013). This thesis describes a study designed to validate an instrument intended to capture secondary school students’ evaluation of teaching (SET) ratings in 36 UK schools during the 2012-13 academic year, and a randomised controlled trial (RCT) to evaluate the impact on student progress of a peer-coached consultative feedback intervention for teachers. The thesis concludes that the SecondarySEEQ instrument is valid and reliable for the purpose of capturing AS and A Level students’ perceptions of the quality of teaching they receive from their teachers, a finding which adds weight to the case for SETs as a useful component of a diagnostic feedback system for teachers. I also conclude that the peer-coached intervention had a no detectable effect on student outcomes.
Prospects and Challenges for the US Economy: 2020 and Beyond

This Strategic Analysis examines the US economy's prospects for 2020-23 and the risks that lie ahead. The baseline projection generated by the Levy Institute's stock-flow consistent macroeconomic model shows that, given current fiscal arrangements and the slowdown in the global economy, the pace of the US recovery will slacken somewhat, with a growth rate that will average 1.5 percent over the next several years. The authors then point to three factors that can derail this already weak baseline trajectory: (1) an overvalued stock market; (2) evidence that the corporate sector's balance sheets are more fragile than they have ever been in the postwar period; and (3) risks in the foreign sector stemming from the slowdown of the global economy, an overvalued dollar, and the current administration's erratic trade policy.
Novel insights into biomass delignification with acidic deep eutectic solvents: a mechanistic study of β-O-4 ether bond cleavage and the role of the halide counterion in the catalytic performance

Development of innovative technologies for efficient, yet eco-friendly, biomass delignification is required to achieve higher sustainability than traditional processes. In this context, the use of deep eutectic solvents (DESs) for the delignification process could fulfil these requirements and stands today as a promising alternative. This work focuses on understanding the fundamental chemistry behind the cleavage of the β-O-4 ether bond present in 2-phenoxy-1-phenylethanol (PPE), a lignin model compound, with three acidic DESs, including Propionic acid/Urea (PA : U), Lactic acid/Choline Chloride (LA : ChCl) and p-Toluenesulphonic acid/Choline chloride (pTSA : ChCl). The acidic nature of each DES influenced the efficiency of PPE cleavage and determined the extent of further side reactions of cleavage products. Although PA : U (2 : 1) demonstrated the ability to dissolve lignin, it is unable to cleave β-O-4 ether linkage in PPE. On the other hand, LA : ChCl (10 : 1) allowed PPE cleavage, but an esterification between the PPE and lactic acid as well as oligomerization of lactic acid was detected. Among the examined solvents, pTSA : ChCl (1 : 1) demonstrated the highest performance in the PPE cleavage, although the high acidity of this system led to the condensation of cleavage products with prolonged time. The presence of water decreases the ability of DESs for cleavage, but the extension of undesired side reactions was also reduced. Finally, the analysis of intermediates and products of the reactions allowed the identification of a chlorinated species of PPE that precedes the cleavage reaction. A kinetic study using pTSA : ChCl (1 : 1) and pTSA : ChBr (1 : 1) was performed to unveil the role of the halide counterion present in DESs in the cleavage of the β-O-4 ether bond and a new reaction mechanism was herein proposed and supported by density functional theory (DFT) calculations.
Effect of Pretreatment on the Quality Characteristics of Osmodried Mango Slices

Mango known as “King of Asiatic fruits”, originated in India is admired all over the world. In area of production and nutritive value no other fruit can compete with it. Fruits are perishable, seasonal and region specific. They are sometimes wasted in large quantities due to the absence of facilities and know how for proper handling, storage, distribution and marketing. Hence, fruit processing becomes critical as this would mop up surpluses at farm level and ensure fair price and also make them available at reasonable price for the consumer all through the year. Osmotic dehydration is a novel technique for the production of shelf stable, nutritious and tasty products. Osmo dried fruits serve as an excellent snack food International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 11 (2019) Journal homepage: http://www.ijcmas. com
Leadership Style, Intellectual Capital, Corporate Social Responsibility and Corporate Performance: A Comparative study between two Indonesian Industries

Objective – The purpose of this paper is to examine the effect of of leadership style, intellectual capital and corporate social responsibility on performance Design/methodology – Data was gathered from two sources. To assess the leadership style, questionnaires were distributed and filled by staff working in sample companies from both. Meanwhile, secondary data collected from financial statements from 2012 to 2018 of each company samples. This study uses census sampling method. Results – The results of this study demonstrated that leadership style has a negative influence on ROA, ROE and Sales Growth for both sector. The intellectual capital has a significant positive influence on ROA, ROE and Sales Growth. Furthermore, in the infrastructure, utilities, and transportation sector, the corporate social responsibility has a negative influence on ROA, a significant positive effect on ROE and not significant on sales growth. Meanwhile, the results from the companies in the basic industries and chemical sectors shows that corporate social responsibility has a negative influence on ROA, ROE and sales growth. Research limitations/implications – A study which compare companies from different industries is still limited. This study focuses on Basic Industry and Chemicals sector and the Infrastructure, Utilities and Transportation Sector in Indonesia, and it is possible that these results are only applicable to the these sector. More research is therefore needed to further understand the contribution of performance to other sectors. Practical Implication - The results are important for management policy development, for example, in terms of prescribing the competences of leadership to enhance firm performance
Utilization of renal mass biopsy in patients with localized renal cell carcinoma: A population-based study utilizing the National Cancer Database.

OBJECTIVE To evaluate trends and factors predicting use of renal mass biopsy (RMB) for localized Renal Cell Carcinoma in the United States (US) in the context of current guidelines recommendations. METHODS We queried the National Cancer Database for cT1-cT3N0M0 Renal Cell Carcinoma diagnosed between 2004 and 2015. Temporal trends of RMB were characterized based on tumor size, treatment (partial nephrectomy [PN], radical nephrectomy [RN], ablation, and no treatment), age and Charlson Comorbidity Index with slopes compared using analysis of variance. Multivariable analysis was used to determine factors associated with use of RMB. RESULTS Of 338,252 patients analyzed, 11.9% (40,276) underwent RMB. Use of RMB increased throughout the study period from 1,586 (7.6%) in 2004 to 5,629 (16.2%) in 2015 (P < 0.001). Use of RMB increased greatest for ablation (27 to 63%, P < 0.001) and tumors 2-4 cm (9 to 20%, P < 0.001). Multivariable analysis showed year of diagnosis (OR = 1.06; P < 0.001), higher education (OR = 1.09; P < 0.001) and insured status (OR = 1.23; P < 0.001) were associated with increased RMB. Compared to tumors ≤2 cm, tumors 2.1-4 cm (OR = 1.36; P=<0.001), 4.1-7 cm (OR = 1.18; P <0.001) and >7 cm (OR = 1.05; P = 0.03) were associated with higher rates of RMB. Compared to RN, PN was not associated with increased RMB (OR = 1.00; P = 0.92), while ablation (OR = 10.90; P < 0.001) and no surgical treatment (OR = 4.83; P < 0.001) were. CONCLUSION RMB utilization increased overall, with largest increase associated with ablation. Nonetheless, only two-thirds of patients underwent RMB with ablation, suggesting persistent underutilization. Rates of RMB for tumors ≤2 cm and in those undergoing no treatment increased less, suggesting less utilization for surveillance. However, rates for tumors >2-4 cm increased more, suggesting selective utilization of RMB to guide decision-making and risk stratification in small renal masses.
Integration in European coal markets, 1833–1913†

This article analyses coal market integration in Europe over the long nineteenth century. The market integration of coal, a key commodity associated with the industrial revolution, is an aspect of European economic history that has received little attention. The literature on the evolution of markets has concentrated on agricultural products, mostly cereals. This article examines intra‐ and international market integration in the principal coal‐producing countries, Britain, Germany, France, and Belgium; and adds three main consuming southern European countries to the analysis of the international market. It provides new evidence on prices, as well as trade, and uses a straightforward approach to address coal price behaviour. Despite shocks, clear trends toward integration in both domestic and international markets can be observed, even if by one of our measures the latter started at a later date. Processes of market integration, however, seemed to slow from the end of the nineteenth century. Explanations are offered as to the causes of the extent and timing of integrations: reductions, mainly, in transportation costs, but also in information costs, and, in the international market, protectionism. The influence of cartels, on the other hand, may have been limited, particularly in the international market.
The Feasibility of Community-Based, Supervised Exercise Programs to Engage and Monitor Patients in a Postrehabilitation Setting

Objective. To evaluate the feasibility of disease-specific, community-based supervised exercise programs (CSEPs) to improve biometric and functional outcomes among persons with a variety of chronic medical conditions. Design. Feasibility, cohort study. Subjects were recruited through community placed flyers and provider offices. Exercise programs consisted of aerobic and resistance training that adhered to American College of Sports Medicine guidelines. A Wilcoxon signed rank test was used to assess program outcomes. Setting. Ten, community-based, medical fitness centers. Subjects. A total of 382 total participants. The number of participants in each CSEP ranged from 38 to 119. Individuals were 18 years of age or older and treated for various chronic medical conditions. Results. Varied by cohort, but generally consisted of (a) favorable changes in body composition ( P < .05), (b) significant improvements in submaximal exercise tolerance and functional outcome measures ( P < .05), and (3) significant increase in self-reported exercise behaviors ( P < .05). Conclusion. CSEPs improve outcomes in patients with chronic medical conditions and may be relevant within the continuum of care in outpatient rehabilitation medicine, particularly among bundled or value-based payment models. Further research is needed to evaluate outcomes from CSEPs versus controls.
Knee joint reconstruction using liquid nitrogen recycled autograft prosthesis composite after wide resection for high-grade chondrosarcoma

Background: Chondrosarcoma is the second most common malignant primary tumor of bone. The prognosis for chondrosarcoma depends mainly on its histologic grading and location. High-grade chondrosarcoma has higher a tendency to recur and metastasize. The standard treatment for chondrosarcoma is wide resection without adjuvant therapy. Numerous reconstructive options are available, varying from endoprostheses, biological reconstruction using allografts or osteoarticular allografts, and recycling of tumor-bearing segment. Methods: We retrospectively reviewed seven patients with high-grade chondrosarcoma who underwent wide resection of the tumor mass and reconstruction using liquid nitrogen treated recycled autograft prosthesis composite. Evaluation was done for local recurrence, metastasis, graft-bone union, osteosynthesis, implant, or graft-related complications. The functional outcome was assessed by the Musculoskeletal Tumour Society scoring system. Results: The mean follow-up period was 46 mo (range 24-65 mo). The average duration for graft union was 8.2 mo (range 7-10 mo). No local recurrence was detected in any patient. None of them had any metastatic deposits. One had a superficial wound infection. One had fulminant infection that required hip disarticulation. The mean Musculoskeletal Tumour Society functional score was 67.7% (range 60-78). Conclusions: Recycled autograft prosthesis composite using liquid nitrogen is an oncologically safe and effective reconstructive option for the management of chondrosarcoma around the knee. It maintains knee function and restores the bone stock. It overcomes endoprosthesis-related problems, overcoming the obstacles of allograft in countries where it is not available or not socially or religiously acceptable.
A Study to Compare the Safety and Efficacy of Solifenacin, Tamsulosin and Tadalafil in Relieving Double-J Stent Related Symptoms

Objective: To evaluate and compare the safety and efficacy of Solifenacin, Tamsulosin, and Tadalafil in treating ureteral stent related symptoms (SRS) in patients with indwelling Double-J ureteral stents. Materials and Methods: A prospective randomized controlled study was conducted on 146 consecutive patients in the department of urology, Government Stanley Medical College & Hospital, Chennai, Tamilnadu, India between Sept 2017-March 2019, with SRS after taking informed consent and confirming DJ Stent position by X-ray KUB post-operatively. Patients were randomized into 4 groups: Group A (Placebo), Group B (Solifenacin 5 mg), and Group B (Tamsulosin 0.4 mg) and group D (Tadalafil 5 mg) at end of 1st week till the removal of DJ stent at end of 3 weeks. All patients were assessed for bothersome lower urinary tract symptoms (LUTS) using the validated Ureteral Stent Symptom Questionnaire (USSQ) at 1st week and 3 weeks after the starting of medications. Appropriate statistical analysis as carried out and the level of significance was set at P α-blockers in relieving urinary symptoms and is more efficacious in relieving sexual symptoms and body pain.
No Vergence Size Constancy

Abstract Vergence (the angular rotation of the eyes) is thought to provide essential distance information for size constancy (perceiving an object as having a constant physical size). Evidence for this comes from the fact that a target with a constant retinal size appears to shrink as the rotation of the eyes increases (indicating that the target has reduced in distance). This reduction in perceived size is supposed to maintain a constant perception of physical size in natural viewing conditions by cancelling out the increasing size of the retinal image as an object moves closer. Whilst this hypothesis has been extensively tested over the last 200 years, it has always been tested in the presence of confounding cues such as a changing retinal image or cognitive cues to distance. Testing members of the public with normal vision, we control for these confounding cues and find no evidence of vergence size constancy. Statement of Relevance This work has important implications for the neural basis of size constancy and for multisensory integration. First, leading work on the neural basis of size constancy cannot differentiate between recurrent processes in V1 (based on triangulation cues, such as vergence) and top-down processing (based on pictorial cues). Since our work challenges the existence of vergence size constancy, and therefore much of the basis of the recurrent processing account, our work indicates that top-down processing is likely to have a much more important role in size constancy than previously thought. Second, vergence size constancy is thought to be largely responsible for the apparent integration of the retinal image with proprioceptive distance information from the hand in the Taylor illusion (an afterimage of the hand viewed in darkness appears to shrink as the observer’s hand is moved closer). This explanation for the Taylor illusion is challenged, and a cognitive account proposed instead.