Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Dapagliflozin in Chronic Kidney Disease, With and Without Other Cardiovascular Medications: DAPA‐CKD Trial

Background The DAPA‐CKD (Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease) trial (NCT03036150) demonstrated that dapagliflozin reduced the risk of kidney and cardiovascular events in patients with chronic kidney disease and albuminuria with and without type 2 diabetes. We aimed to determine whether baseline cardiovascular medication use modified the dapagliflozin treatment effect. Methods and Results We randomized 4304 adults with baseline estimated glomerular filtration rate 25 to 75 mL/min per 1.73 m2 and urinary albumin:creatinine ratio 200 to 5000 mg/g to dapagliflozin 10 mg or placebo once daily. The primary end point was a composite of ≥50% estimated glomerular filtration rate decline, end‐stage kidney disease, and kidney or cardiovascular death. Secondary end points included a kidney composite end point (primary composite end point without cardiovascular death), a cardiovascular composite end point (hospitalized heart failure or cardiovascular death), and all‐cause mortality. We categorized patients according to baseline cardiovascular medication use/nonuse. Patients were required by protocol to receive a stable (and maximally tolerated) dose of a renin‐angiotensin‐aldosterone system inhibitor. We observed consistent benefits of dapagliflozin relative to placebo, irrespective of baseline use/nonuse of renin‐angiotensin‐aldosterone system inhibitors (98.1%), calcium channel blockers (50.7%), β‐adrenergic antagonists (39.0%), diuretics (43.7%), and antithrombotic (47.4%), and lipid‐lowering (15.0%) agents. Use of these drugs in combination with dapagliflozin did not increase the number of serious adverse events. Conclusions The safety profile and efficacy of dapagliflozin on kidney and cardiovascular end points in patients with chronic kidney disease were consistent among patients treated and not treated at baseline with a range of cardiovascular medications. Registration Information clinicaltrials.gov. Identifier: NCT03036150.
Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation

Background: Sarcopenia is a skeletal muscle mass deficiency and a potential prognostic factor for the recurrence of hepatocellular carcinoma (HCC). Objective: To determine whether sarcopenia correlates with the recurrence rate of HCC after curative radiofrequency ablation (RFA) in early and very early HCC. Methods: We retrospectively reviewed 669 HCC patients who underwent their first curative RFA at Siriraj hospital from 2011 to 2020. Fifty-six patients who were diagnosed with HCC by triple-phase CT scan and had complete response on follow-up CT were included. All patients underwent skeletal muscle index (SMI) assessment at level L3 vertebra and sarcopenia was defined by the cut-off values of 52.4 cm2/m2 for men and 38.5 cm2/m2 for women. We compared patients with and without sarcopenia. Time to recurrence was evaluated by the Kaplan-Meier method. Univariate and multivariate Cox regression analysis was performed. Results: Sarcopenia was present in 37 of 56 patients (66.1%). There was no significant difference between groups except body mass index (BMI) (P<0.001) and serum alanine aminotransferase (ALT) (P=0.035). There was a promising result indicating the difference of time to recurrence between each group (P=0.046) and potential association of sarcopenia with HCC recurrence (HR=2.06; P=0.052). The Child-Pugh score and tumor number were independent risk factors for HCC recurrence (HR=2.04; P=0.005 and HR=2.68; P=0.017, respectively). Conclusion: Sarcopenia is a potential prognostic factor for recurrence of HCC in Thai patients who underwent RFA. A larger study is required to properly confirm this association.
Mapping EORTC-QLQ-C30 onto EQ-5D-5L Index in Indonesian Cancer Patients

Objective: This study aims to develop a mapping algorithm for EORTC QLQ-C30 to EQ-5D-5L which can produce utility values in patients with cancer. Methods: We used a cross sectional study design with 300 cancer patients. The research instruments used were EORTC QLQ-C30 and EQ-5D-5L. Data were collected by interviewing cancer patients who were hospitalized in the Kasuari Installation of Dr Kariadi Hospital Semarang, Indonesia. The Ordinary Least Squares (OLS) regression method was used to predict the utility value of EQ-5D-5L. This study uses two models to predict utility values, namely model 1 with all domains, and model 2 with domains that affect the EQ-5D-5L. The predictive power of regression on the model is evaluated by calculating the mean absolute error (MAE) and root mean square error (RMSE) values. Result: The highest score in the functional domain is the ‘emotional function’ domain (mean: 85.89; SD: 16.04) and the highest symptom domain is ‘weakness’ (mean: 36.21; SD:21.69). The predicted utility values of models 1 and 2 are 0.683. The mean absolute error (MAE) and root mean square error (RMSE) values of model 1 are 0.128 and 0.173, while in model 2 the MAE and RMSE values obtained are 0.125 and 0.168. Conclusion: The development of the mapping algorithm from the EORTC QLQ-C30 to EQ-5D-5L instrument shows a predictive value of utility in a sample of patients with cancer at Dr. Kariadi Hospital, Semarang, Indonesia. The utility prediction in both model is similar, however model 2 involves fewer domains and symptoms.
Saudi Nursing Students’ Knowledge and Perception of Testicular Cancer Assessment and Management: A Cross-Sectional Study

Introduction: Testicular cancer (TC) incidence is increasing worldwide. This study aimed to investigate Saudi nursing students’ knowledge and perception about TC. Method: This cross-sectional study was done using convenience sampling method. In this study, 280 nursing students from different nursing schools in six cities of Saudi Arabia were recruited. A structured self-report questionnaire was used to collect data. Result: About 49.2% of the participants received education about TC in their nursing schools. The findings showed lack of enough knowledge about TC among Saudi nursing students. Mostly, the participants reported that heredity factor and having family history of TC (48.9%) and age between 56 and 70 years (41.8%) were the most common risk factors of TC. According to the participants, physical examination was the most common diagnostic test usually used for early detection of TC (40.4%) and biopsy test was the most accurate test to confirm TC diagnosis (45.4%). Only one third of the participants (34.6%) knew that between 75% and 100% of TC cases can be cured in case of early detection. About half of the participants (51.8%) reported that surgical procedure was the most common treatment for TC. The nursing students who had high GPA (r=0.86, p<0.001), were unwilling to get more information on TC (r=0.24, p=0.04), had family history of TC (r= 0.53, p=0.02), medical problems with testicles (r= 0.69, p=0.01), received education about TC in their school of nursing (r=0.65, p=0.02), and were more self-confident in assessing and managing TC (r=0.38, p=0.03) had higher level knowledge about TC. Conclusion: Despite the importance of nurses’ roles in assessing and managing TC, nursing students in Saudi Arabia still did not have enough knowledge about TC. Improving nursing programs’ curricula and conducting health education programs are recommended.
A Study of Van Hiele of Geometric Thinking among 1st through 6th Graders.

Background:This study presents partial results from the project “A Study of perceptual apprehensive, operative apprehensive, sequential apprehensive, and discursive apprehensive for elementary school students (POSD)”, which was undertaken to explore gender differences and passing rate of van Hiele’s geometric thinking level.Materials and methods:The participants were 5,581 elementary school students randomly selected from 23 counties/cities in Taiwan.Results:This paper analysed the passing rate of van Heile geometric thinking of Taiwanese 1st to 6th graders, and studied the gender differences at different grades. The statement below shows the passed population and the passing rate.Conclusions:The conclusions drawn from this study were: (a) evidence supporting the hierarchy of the van Hiele levels, (b) students at different levels have different concepts of basic figures, and (c) for elementary school students, the passing rates of boys and girls have no significant differences in van Hiele’s geometric thinking level.
Circularity and consistency in paired comparisons

Let R be a linear order on a set Z = {x, y,…} of n objects. Let Dm and D(t) be systems of paired comparisons on Z such that in every one of the pairs with xRy the system Dm contains an observed proportion p = 0, 1/m,…, 1 of choices for x over y while D(t) contains a probability of choosing x over y as given by a choice theory (t) which also specifies R. For systems D1 a circularity index is proposed as an alternative to Kendall's and Slater's consistency indices. Some properties of these three indices are investigated in the sets of all possible D1 for some small n. If m > 1, Dm may be more or less compatible with D(t) and also give rise to a D1, estimating R. It is argued that the compatibility of Dm with D(t) may be regarded as an index of the external consistency of D1, with respect to R which is to be distinguished from its circularity or internal consistency. This distinction is corroborated by computer simulations of paired comparisons under Thurstone's case V model. The correlations between the three circularity indices and four indices of external consistency are essentially zero. Finally, the bearing of assessing circularity to the assessing and testing of the (in)transitivity of data systems is indicated.
Magnetoacoustic tomography with magnetic induction for imaging electrical impedance of biological tissue

An experimental feasibility study was conducted on magnetoacoustic tomography with magnetic induction (MAT-MI). It is demonstrated that the two-dimensional MAT-MI system can detect and image the boundaries between regions of different electrical conductivities with high spatial resolution. Utilizing a magnetic stimulation coil, MAT-MI evokes magnetically induced eddy current in an object which is placed in a static magnetic field. Because of the existence of Lorenz forces, the eddy current in turn causes acoustic vibrations, which are measured around the object in order to reconstruct the electrical impedance distribution of the object. The present experimental results from the saline and gel phantoms are promising and suggest the merits of MAT-MI in imaging electrical impedance of biological tissue with high spatial resolution.
Validation of TRMM and Other Rainfall Estimates with a High-Density Gauge Dataset for West Africa. Part II: Validation of TRMM Rainfall Products

Gauge data from a West African network of 920 stations are used to assess Tropical Rainfall Measuring Mission (TRMM) satellite and blended rainfall products for 1998. In this study, mean fields, scattergrams, and latitudinal transects for the months of May‐September and for the 5-month season are presented. Error statistics are also calculated. This study demonstrates that both the TRMM-adjusted Geostationary Observational Environmental Satellite precipitation index (AGPI) and TRMM-merged rainfall products show excellent agreement with gauge data over West Africa on monthly-to-seasonal timescales and 2.5 83 2.58 latitude/longitude space scales. The root-mean-square error of both is on the order of 0.6 mm day 21 at seasonal resolution and 1 mm day21 at monthly resolution. The bias of the AGPI is only 0.2 mm day21, whereas the TRMM-merged product shows no bias over West Africa. Performance at 1.0 83 1.08 latitude/longitude resolution is also excellent at the seasonal scale and good for the monthly scale. A comparison with standard rainfall products that predate TRMM shows that AGPI and the TRMM-merged product perform as well as, or better than, those products. The AGPI shows marked improvement when compared with the GPI, in reducing the bias and in the scatter of the estimates. The TRMM satellite-only products from the precipitation radar and the TRMM Microwave Imager do not perform well over West Africa. Both tend to overestimate gauge measurements.
Predicting short‐term and long‐term mortalities from sepsis in patients who receive allogeneic haematopoietic stem cell transplantation

Patients who receive allogeneic haematopoietic stem cell transplantation (allo‐HSCT) may develop sepsis, which result in a highly intensive care unit admission rate and mortality. Therefore, short‐term and long‐term prognostic models for sepsis after allo‐HSCT are urgently needed. We enrolled patients receiving allo‐HSCT who developed sepsis after allo‐HSCT at Peking University People's Hospital between 2012 and 2021, including 287 patients who received allo‐HSCT in 2018–2021 in the derivation cohort, and 337 patients in 2012–2017 in the validation cohort. Multivariate logistic regression analysis was used to identify prognostic factors, and these identified factors were incorporated into two scoring models. Seven independent factors (acute graft‐versus‐host disease (GVHD), chronic GVHD (cGVHD), total bilirubin, lactate dehydrogenase (LDH) and organ dysfunction [renal, lung and heart]) were included in the 6‐month prognostic model, and six factors (cGVHD, C‐reactive protein, LDH, organ dysfunction [lung, neurologic and coagulation]) were included in the 14‐day prognostic model. The area under the receiver operating characteristic curves, calibration plots and decision curve analysis demonstrated the robust predictive performance of the models, better than the Sequential Organ Failure Assessment score. Early identification of patients with high risk of 6‐month and 14‐day death may allow clinicians to provide timely treatments and improve the therapeutic effects.
Linearly Polarized Excitons in Single- and Few-Layer ReS2 Crystals

Rhenium disulfide (ReS2), a layered group VII transition metal dichalcogenide, has been studied by optical spectroscopy. We demonstrate that the reduced crystal symmetry, as compared to the molybdenum and tungsten dichalcogenides, leads to anisotropic optical properties that persist from the bulk down to the monolayer limit. We find that the direct optical gap blueshifts from 1.47 eV in the bulk to 1.61 eV in the monolayer limit. In the ultrathin limit, we observe polarization-dependent absorption and polarized emission from the band-edge optical transitions. We thus establish ultrathin ReS2 as a birefringent material with strongly polarized direct optical transitions that vary in energy and orientation with sample thickness.
Genetic Characterization of Ovarian Tumor Tissues from Patients with Epithelial Ovarian Cancer in a Philippine Tertiary Hospital: A Descriptive Study

Objective: This study identified genetic variations in ovarian tumor specimens from Filipino epithelial ovarian cancer (EOC) patients using next-generation sequencing. Methods: Genomic DNA was isolated from formalin-fixed paraffin-embedded ovarian specimens from 8 chemosensitive and 8 chemoresistant EOC patients. Targeted next-generation sequencing was done to identify mutations in hotspot regions of common oncogenes and tumor-suppressor genes. The mutations were cross-referenced with dbSNP and ClinVar databases to identify previously reported alterations, and potentially damaging variants were predicted using PolyPhen-2. Results: Our study has identified 85 unique variants, 35 in chemosensitive EOC, 22 in chemoresistant EOC, and 28 in both. Chemosensitive EOC specimens had more exonic single nucleotide variants than chemoresistant EOC specimens. Of the 50 oncogenes and tumor suppressor genes, KDR gene had the most frequent variations in EOC patients. Two of the unique KDR variants identified were novel mutations. Thirty-nine unique protein-modifying genetic variants were identified in all specimens, the majority of which have been previously reported in dbSNP and ClinVar. Conclusion: This study was the first non-BRCA genetic analysis done on ovarian cancer in Filipino patients. Next-generation sequencing was able to identify previously reported alterations with known therapeutic implications which may benefit from targeted therapy instead of standard chemotherapy regimen.
The Feasibility and Safety of Induction Chemotherapy Followed by Definitive Chemoradiation in Patients with Locally Advanced Cervical Cancer: A Single-Arm Phase II Clinical Trial

Background: The present study aimed at investigating the feasibility and safety of induction chemotherapy followed by definitive chemoradiation (dCRT) in patients with locally advanced cervical cancer. Materials and Methods: In this single-arm clinical trial, patients with cervical cancer (stages IB3-IVA) received a median four cycles of induction chemotherapy (paclitaxel and carboplatin, every three weeks) followed by dCRT (which consisted of the whole pelvis at the dose of 45-50 Gy along with weekly cisplatin (40 mg/m2) followed by intracavitary brachytherapy at the total dose of 80-90 Gy). Primary end point was local control at three months, which was assessed by gynecologic examination and pelvic MRI. The secondary outcome of the study was treatment-related toxicity. Results: Seventy-four patients with the mean age of 51.6 ± 9.5 years were included. The most frequent (51.4%) disease stage was IIB. Complete and partial clinical responses were observed in 60.8% and 14.9% of patients, respectively. The frequency of progressive disease and stable disease were 14.9% and 9.5%, respectively. Grade II and III neutropenia (during neoadjuvant chemotherapy were 13.5% and 2.7%, respectively; these figures during chemoradiation were 29.7% and 13.5%, respectively. A treatment interruption was observed for 60.8% (45 cases) of patients during chemoradiation and 31.1% during induction chemotherapy. Discussion and conclusion: Induction chemotherapy followed by chemoradiation is feasible in patients with locally advanced cervical cancer; however, the toxicity should be managed properly to avoid delayed e treatment. More than three quarters of the patients achieved complete or partial clinical response within a three-month follow-up.
Follow-Up Strategies and Detection of Recurrent Breast Cancer in the Modern Era

Background: Regular history assessments and physical examination with annual breast imaging have been recommended as the standard surveillance protocol for breast cancer patients who underwent curative-intent therapy. Based on randomized studies conducted in the 2000s, surveillance with regular chest or abdominal imaging, chemistry panels, or tumor marker measurements does not improve survival in such patients. Given the remarkable recent improvements of systemic therapy, we hypothesized that more intensive surveillance may lead to early detection and improve treatment outcomes in the modern era. Methods: We retrospectively evaluated the follow-up strategies and benefits of investigations used in usual practice. Breast cancer patients who had initial adjuvant therapy were recruited and classified according to the receipt of standard follow-up (history, physical examination, and annual breast imaging) or alternative follow-up (surveillance with at least annual chest or abdominal imaging or biannual liver function testing). The primary outcome was overall survival. Secondary outcomes included disease-free survival and the indicator of recurrence detection. Results: Of 412 recruited patients, 213 (51.7%) and 199 patients (49.3%) were included in the standard follow-up group and alternative follow-up group, respectively. Among 90 patients (21%) with disease recurrence, the most frequent indicators of recurrence were newly reported symptoms or physical examination abnormalities (64%), followed by abnormal breast imaging (23%) and abnormal chest X-ray (10%). After a median follow-up of 85 months, approximately 90% of patients remained alive after 5 years in both groups. The mean overall survival was similar between the standard and alternative follow-up groups (154.5 months vs. 151.9 months, p = 0.54). There was no difference in terms of the proportion of interval visits, specific cancer treatment received, and disease-free survival. Conclusion: Standard follow-up with history assessments, physical examination, and annual breast imaging remains the recommended surveillance strategy in the modern era. Alternative follow-up strategy did not improve oncologic outcomes.
Scattering for a Nonlinear Schrödinger Equation with a Potential

We consider a 3d cubic focusing nonlinear Schrodinger equation with a potential $$i\partial_t u+\Delta u-Vu+|u|^2u=0,$$ where $V$ is a real-valued short-range potential having a small negative part. We find criteria for global well-posedness analogous to the homogeneous case $V=0$ [10, 5]. Moreover, by the concentration-compactness approach, we prove that if $V$ is repulsive, such global solutions scatter.
Time‐accurate stabilized finite‐element model for weakly nonlinear and weakly dispersive water waves

Introduction of a time‐accurate stabilized finite‐element approximation for the numerical investigation of weakly nonlinear and weakly dispersive water waves is presented in this paper. To make the time approximation match the order of accuracy of the spatial representation of the linear triangular elements by the Galerkin finite‐element method, the fourth‐order time integration of implicit multistage Padé method is used for the development of the numerical scheme. The streamline‐upwind Petrov–Galerkin (SUPG) method with crosswind diffusion is employed to stabilize the scheme and suppress the spurious oscillations, usually common in the numerical computation of convection‐dominated flow problems. The performance of numerical stabilization and accuracy is addressed. Treatments of various boundary conditions, including the open boundary conditions, the perfect reflecting boundary conditions along boundaries with irregular geometry, are also described. Numerical results showing the comparisons with analytical solutions, experimental measurements, and other published numerical results are presented and discussed. Copyright © 2007 John Wiley & Sons, Ltd.
Reactions to Participation in Research on Violence Experiences and Minority Stress Among Sexual and Gender Minority Young Adults

Given the growing body of research seeking to examine adverse childhood experiences (ACEs) and intimate partner violence (IPV) among sexual and gender minority (SGM) individuals, Institutional Review Boards must consider whether participating in violence research is emotionally distressing for SGM people. Yet, little research has studied SGM participants’ reactions to participating in research on ACEs, IPV, and minority stress. Thus, the current study examined reactions, including negative emotional reactions, to participating in violence research among SGM young adults. In total, 230 participants who self-identified as a sexual minority (30.1% also identified as a gender minority) in a dating relationship completed a cross-sectional assessment on ACEs, IPV (including identity abuse victimization and perpetration), minority stress (i.e., internalized homo/bi/transphobia), and reactions to research participation. Results indicated that participants identifying as a gender minority had significantly higher negative emotional reactions to study participation compared to cisgender participants, but this increase among gender minority individuals was small. In addition, gender minority participants and those with higher minority stress (i.e., internalized trans/bi/homo-negativity) and ACEs reported significantly higher negative emotional reactions to participation. Furthermore, gender minority participants scored worse on a scale indicating appreciation for contributing to research. Finally, reporting IPV victimization and perpetration was not associated with negative emotional reactions. Findings suggest that questions assessing minority stress and negative childhood experiences may be more emotionally salient or stressful for gender minority participants compared to questions measuring IPV.