Miracle-dz/UniFAR-FTUs huggingface dataset:
Late‐glacial and Holocene river development in the Teleorman Valley on the southern Romanian Plain

This paper reports on a radiocarbon‐dated sequence of alluvial terraces from the Teleorman Valley in the southern Romanian Plain and represents the first Late‐glacial and well‐constrained Holocene alluvial sequence from the lower Danube Valley of southeast Europe. The two earliest and most extensive terraces (T1 and T2) are dissected by large, high‐amplitude palaeochannels, which are dated to ca. 12 800 yr BP and are comparable to large meandering palaeochannels identified from other Late glacial contexts across northern and central Europe. The remaining sequence of alluvial deposits show changes in river activity and accelerated sedimentation around 4900–4800 yr BP, 4000–3800 yr BP, 3300–2800 yr BP, 1000 yr BP and within the past 200 yr. A phase of tributary stream alluvial fan deposition is dated to ca. 2400 yr BP. All these periods of alluvial sedimentation correlate well with episodes of climatic cooling, higher rainfall and enhanced river activity, both in terms of incision and greater lateral mobility as well as increased flood frequency and magnitude identified elsewhere in central, western and northern Europe. Human activity appears to have had little effect on this river environment and significant fine‐grained sedimentation is not noted until ca. 2400 yr BP, approximately 5000 yr after the first neolithic farmers settled the area. Whether this record of river activity truly reflects the impact of prehistoric societies on this catchment will only be elucidated through further, ongoing detailed archaeological research. Copyright © 2003 John Wiley & Sons, Ltd.
An Experimental Study on The Oxidative Status and Inflammatory Levels of A Rat Model of Polycystic Ovary Syndrome Induced by Letrozole and A New High-Fat Diet

Background: Although there are numerous animal models of polycystic ovary syndrome (PCOS), they often fail to accurately replicate the reproductive and metabolic phenotypes associated with PCOS. The objective of this study is to assess oxidative status and inflammatory levels in a rat model of PCOS subjected to a new high-fat diet (HFD) in combination with letrozole. Materials and Methods: In this experimental study, mature, six-week-old female Sprague-Dawley rats (n=20) were divided into four groups: control (standard diet); letrozole (letrozole plus a standard diet); HFD; and letrozole+HFD. After 16 weeks, the rats underwent vaginal smear analysis, measurement of hormonal and lipid profiles, and an oral glucose tolerance test (OGTT). Ovarian tissue morphology, oxidative parameters, and inflammatory status were evaluated. Results: The experimental groups exhibited anoestrus profiles in the vaginal smears and abnormal ovarian morphology, which was not observed in the control group. Steroid hormone levels were significantly higher in the letrozole+HFD group compared to the other groups (P=0.00). The experimental groups also showed abnormal glucose levels and lipid metabolism. The relative expression levels of inflammatory genes were significantly elevated in the experimental groups compared to the control group (P=0.00), and the letrozole+HFD group exhibited the highest expression level (P=0.00). The HFD, letrozole, and letrozole+HFD groups demonstrated significantly increased levels of malondialdehyde (MDA) and reactive oxygen species (ROS), while the levels of enzymatic antioxidants were significantly reduced compared to the control group (P=0.00). Conclusion: The combination of a new HFD and letrozole treatment induces inflammation and oxidative stress (OS) in a rat model of PCOS. This model accurately exhibits abnormal metabolic phenotypes and disruptions in hormonal profiles associated with PCOS.
Bolboforma (Phytoplankton Incertae Sedis), Bachmayerella and other Calciodinelloidea (Phytoplankton) from the Middle Miocene of the Alpine–Carpathian Foredeep (Central Paratethys)

Bolboforma is a microfossil of uncertain origin with affinities to protophytic algae. It generally occurs at high latitudes and/or in cool and temperate waters and has a high stratigraphic potential especially for the Miocene. Calcareous cysts of dinoflagellates represent the ‘benthic cyst stage’ of unicellular organisms belonging to the marine phytoplankton. The occurrence of Bolboforma, Bachmayerella is documented here and, for the first time, some calcareous cysts of dinoflagellates tentatively attributed to Alasphaera and Pithonella from Badenian (Langhian–Middle Miocene) sediments in Austrian and Moravian localities. Alasphaera and Pithonella were previously described from Cretaceous and Danian sediments only, therefore, their range has been extended into the Paratethyan Middle Miocene. Correlation of Bolboforma bioevents with standard geological time-scales allows confirmation, and in some cases refinement, of age assignments based on other microfossil groups, such as foraminifera and calcareous nannofossils, in Paratethyan areas. In particular, this paper presents a case study of the biostratigraphy of the Grund Formation outcropping at its type locality in Lower Austria. Age attribution of the Grund Formation has been uncertain for some time. The recovery of Praeorbulina glomerosa circularis and Uvigerina macrocarinata, associated with Bolboforma reticulata, allows the correlation of the Grund Formation with the Early Badenian (Middle Miocene). As planktonic foraminifera are generally very rare or absent in shelf deposits of many other Austrian and Moravian Middle Miocene sedimentary sequences, Bolboforma, and in particular B. reticulata, remains an important biomarker to identify lower Badenian sediments. Additionally, the new species Bolboforma gneixendorfensis Spezzaferri & Rögl is described. It is generally double-chambered with a weakly reticulate wall texture and is associated with Bolboforma reticulata, B. bireticulata and/or B. moravica.
Fine‐scale spatial variability of throughfall amount and isotopic composition under a hardwood forest canopy

Stable isotopes of water can give clues to the physical processes of forest canopy interception. We examined whether fine‐scale canopy structure is related to throughfall amount and isotopic variation by intensively quantifying both throughfall and canopy structure in a broadleaf, deciduous forest in Louisiana, USA. Local throughfall amount was correlated with canopy structure quantified as distance to the nearest tree, local crown coverage, and local crown length; isotopic composition was also correlated with the same variables but weakly. Spatial patterns of throughfall amount showed some consistency across storms, but spatial patterns of stable isotopes were much weaker and inconsistent. Spatial autocorrelation was consistent in throughfall amount across events, which suggests fixed controls over patterning of throughfall to the forest floor by the canopy. In contrast, lower spatial and temporal autocorrelation in isotopic composition suggested temporally varying controls over patterning, and that routing through the canopy, intra‐storm isotopic variation of rainfall, isotopic exchange, and evaporation interacted to affect the stable isotopic composition. Copyright © 2015 John Wiley & Sons, Ltd.
Shape-Based Measures Improve Scene Categorization

Converging evidence indicates that deep neural network models that are trained on large datasets are biased toward color and texture information. Humans, on the other hand, can easily recognize objects and scenes from images as well as from bounding contours. Mid-level vision is characterized by the recombination and organization of simple primary features into more complex ones by a set of so-called Gestalt grouping rules. While described qualitatively in the human literature, a computational implementation of these perceptual grouping rules is so far missing. In this article, we contribute a novel set of algorithms for the detection of contour-based cues in complex scenes. We use the medial axis transform (MAT) to locally score contours according to these grouping rules. We demonstrate the benefit of these cues for scene categorization in two ways: (i) Both human observers and CNN models categorize scenes most accurately when perceptual grouping information is emphasized. (ii) Weighting the contours with these measures boosts performance of a CNN model significantly compared to the use of unweighted contours. Our work suggests that, even though these measures are computed directly from contours in the image, current CNN models do not appear to extract or utilize these grouping cues.
Cardiac nitric oxide scavenging: role of myoglobin and mitochondria

Vascular production of nitric oxide (NO) regulates vascular tone. However, highly permeable NO entering the cardiomyocyte would profoundly impact metabolism and signalling without scavenging mechanisms. The purpose of this study was to establish mechanisms of cardiac NO scavenging. Quantitative optical studies of normoxic working hearts demonstrated that micromolar NO concentrations did not alter mitochondria redox state or respiration despite detecting NO oxidation of oxymyoglobin to metmyoglobin. These data are consistent with proposals that the myoglobin/myoglobin reductase (Mb/MbR) system is the major NO scavenging site. However, kinetic studies in intact hearts reveal a minor role (∼9%) for the Mb/MbR system in NO scavenging. In vitro, oxygenated mitochondria studies confirm that micromolar concentrations of NO bind cytochrome oxidase (COX) and inhibit respiration. Mitochondria had a very high capacity for NO scavenging, importantly, independent of NO binding to COX. NO is also known to quickly react with reactive oxygen species (ROS) in vitro. Stimulation of NO scavenging with antimycin and its inhibition by substrate depletion are consistent with NO interacting with ROS generated in Complex I or III under aerobic conditions. Extrapolating these in vitro data to the intact heart supports the hypothesis that mitochondria are a major site of cardiac NO scavenging.
Influence du tryptophane sur le pouvoir pathogène de Streptomyces scabiei, l'agent causal de la gale commune de la pomme de terre

Streptomyces scabiei is the causal agent of potato common scab but the bacterium is also known for its ability to inhibit the growth of most monocot and dicot seedlings. The virulence of this phytopathogenic agent mainly depends upon the production of a toxin called thaxtomin A. S. scabiei also produces the plant growth hormone auxin [indole-3-acetic acid (IAA)] but the role of this hormone in the interaction between pathogenic stretomycetes and plants has not been elucidated yet. Tryptophan is a biosynthetic precursor of both auxin and thaxtomin A. While the in vitro auxin production by S. scabiei depended mostly on the availability of tryptophan, addition of this amino acid to a culture medium inhibited the biosynthesis of thaxtomin A. Expression of thaxtomin A biosynthetic genes nos and txtA were strongly repressed in the presence of tryptophan, however no modulation of the expression was observed for IAA biosynthetic genes iaaM and iaaH. The effect of an exogenous supply of tryptophan on S. scabiei virulence was assessed on radish seedlings grown under gnotobiotic conditions. Addition of tryptophan reduced symptoms of infected radish roots when compared to seedlings grown in the absence of the bacterium, at the same tryptophan concentration. S. scabiei even acted as a plant growth promoting bacterium at high tryptophan concentrations.
Web-Based Nutrition and Physical Activity Education Intervention to Ameliorate Cardiometabolic Risks: A Single-Arm and Non-Randomized Feasibility Study

Objective: This study aimed to evaluate the feasibility of the D-PATH website to improve dietary and physical activity management for patients with cardiometabolic risk. Methods: A website called D-PATH was developed, consisting of 6 learning units for managing hypertension. A 4-week program was implemented, and a pre- and post-intervention assessment was conducted to measure acceptability and changes in knowledge, attitude and practice, dietary intake, physical activity, and anthropometric status. Results: The D-PATH website was acceptable in terms of understandability, actionability and cognitive load. Knowledge, attitude and practice, and physical activity levels were improved, but no changes were noted for dietary intake and blood pressure level. Conclusion: The D-PATH website was accepted and feasible for the intervention study. This study has shed light on using the website to promote behavioral change in patients with cardiometabolic risks.
Biochemical characteristics and bacterial community structure of the sea surface microlayer in the South Pacific Ocean

The chemical and biological characteristics of the surface microlayer were determined during a transect across the South Pacific Ocean in October-December 2004. Concentrations of particulate organic carbon (1.3 to 7.6-fold) and nitrogen (1.4 to 7-fold), and POC:PON ratios were consistently higher in the surface microlayer as compared to surface waters (5 m). The large variability in particulate organic matter enrichment was negatively correlated to wind speed. No enhanced concentrations of dissolved organic carbon were detectable in the surface microlayer as compared to 5 m, but chromophoric dissolved organic matter was markedly enriched (by 2 to 4-fold) at all sites. Based on pigment analysis and cell counts, no consistent enrichment of any of the major components of the autotrophic and heterotrophic microbial community was detectable. CE-SSCP fingerprints and CARD FISH revealed that the bacterial communities present in the surface microlayer had close similarity (>76%) to those in surface waters. By contrast, bacterial heterotrophic production ( 3 H-leucine incorporation) was consistently lower in the surface microlayer than in surface waters. By applying CARD-FISH and microautoradiography, we observed that Bacteroidetes and Gammaproteobacteria dominated leucine uptake in the surface microlayer, while in surface waters Bacteroidetes and Alphaproteobacteria were the major groups accounting for leucine incorporation. Our results demonstrate that the microbial community in the surface microlayer closely resembles that of the surface waters of the open ocean. Even a short residence in the surface microlayer influences leucine incorporation by different bacterial groups, probably as a response to the differences in the physical and chemical nature of the two layers.
An HGF‐dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis

Cancer‐associated fibroblasts (CAFs) play a vital role in facilitating tumor progression through extensive reciprocal interplay with cancer cells. Tumor‐derived extracellular vesicles (EVs) are the critical mediators involved in the crosstalk between cancer cells and stromal cells, contributing to the metastasis of cancers. Yet, the biological mechanisms of tumor‐derived EVs in triggering CAFs phenotype to stimulate the lymph node (LN) metastasis of bladder cancer (BCa) are largely unknown. Here, we aimed to explore the effects and molecular mechanisms of tumor‐derived EV‐mediated CAFs phenotype in regulating BCa LN metastasis.
Cardiovascular disease risk in patients with inflammatory arthritis nowadays still substantially elevated

Objectives This study aims to assess current cardiovascular disease risk and prevalence of risk factors in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (SpA). Methods 2050 consecutive patients with inflammatory arthritis (IA) and 939 controls were included, with 1308 patients with RA, 356 patients with PsA and 386 patients with SpA. In a prospective cohort setting, questionnaires regarding previous cardiovascular events and risk factors were used to assess cardiovascular risk and prevalence in patients with IA by calculating ORs using logistic regression models. Results ‘Traditional’ cardiovascular (CV) risk factors were significantly elevated in patients with IA compared with controls. Cardiovascular disease (CVD) ORs were increased in patients with RA and PsA compared with controls, 1.61 (95% CI: 1.04 to 2.48) and 2.12 (95% CI: 1.23 to 3.66), respectively, and a trend towards increased odds was observed in patients with SpA (OR 1.43; 95% CI: 0.79 to 2.59). After adjusting for traditional risk factors, CV risk was not increased in patients with RA (OR; 0.95, 95% CI: 0.58 to 1.55), PsA (OR 1.19; 95% CI: 0.64 to 2.22) and SpA (OR; 0.91, 95% CI: 0.47 to 1.77). Conclusion CVD is currently still more prevalent in patients with IA compared with healthy controls and, more importantly, this elevated risk is highly influenced by an increased prevalence of ‘traditional’ CV risk factors. More attention to, as well as improvements in, identification and treatment of ‘traditional’ risk factors, need to be made for not only RA, but other IA conditions as well.
Metabolic imprints in the hydrogen isotopes of Archaeoglobus fulgidus tetraether lipids

The stable hydrogen isotope composition of archaeal lipids is emerging as a potential paleoenvironmental proxy, adding to the well-established application of plant leaf wax-derived n-alkanes in paleohydrological reconstruction. A handful of studies reported relatively invariant and depleted hydrogen isotope compositions for archaeal lipids despite the range of different organisms and growth conditions explored. However, how modes of metabolism and physiological state (growth phase) affect the hydrogen isotope signatures of archaeal lipids remains poorly understood, limiting our ability to interpret archaeal lipid biomarker records from the environment. Here we conducted water isotope label experiments with a metabolically flexible and well-studied model archaeon Archaeoglobus fulgidus and quantified the hydrogen isotope fractionation between lipids and water in response to different carbon substrates and electron donor-acceptor pairs. The 2H/1H fractionation between lipids and water (εL/W) was overall negative, ranging from –280 to –226 ‰, and overlapped with the ranges observed for other archaea in previous studies. Isotope flux-balance model results suggest that ≥80 % and ≥50 % of lipid-bound H in A. fulgidus cultures directly reflect water isotope compositions (i.e., not via organic substrate or H2) during autotrophy and heterotrophy, respectively. The model results also suggest the final saturation during isoprenoid lipid biosynthesis catalyzed by a flavoenzyme geranylgeranyl reductase likely contributes to the large 2H/1H fractionation observed in this study, consistent with previous isotope flux-balance model results for a different archaeon. Finally, we synthesized available data to compare εL/W patterns across all three domains of life: Bacteria, Archaea and Eukarya. Emerging patterns between archaeal and eukaryotic lipids are consistent with the notion of highly fractionating geranylgeranyl reductase, and the patterns between archaeal and bacterial lipids suggest that the general state of energy limitation may also contribute to large, negative values of εL/W observed in prokaryotic lipids. Altogether, these findings lend further support for the potential of archaeal lipid εL/W as a paleohydrological proxy and provide a broader insight into the 2H/1H fractionation mechanisms potentially shared among prokaryotic and eukaryotic lipid biomarkers.
Trends and Variability in Total Ozone from a Mid-Latitude Southern Hemisphere Site: The Melbourne Dobson Record 1978–2012

Abstract The Australian Bureau of Meteorology maintains a number of long-running Dobson measurement programs, among the few in southern hemisphere mid-latitudes. Data from the Melbourne site (the Melbourne/Airport World Ozone and Ultraviolet Radiation Data Centre (WOUDC) station was originally located at Aspendale, then moved to the city centre, and finally to Melbourne Airport) from 1978 to 2012 have recently been reviewed and re-evaluated. These data are analyzed using multi-linear regression and also by application of an 11-year running mean. Satellite data from the Merged Ozone Dataset are also used for comparison with the Dobson results. We show that the Quasi-Biennial Oscillation (QBO) plays a major role in winter and spring once phase is taken into account by month. We also show that the three so-called “classical” proxies (QBO, solar cycle, and Equivalent Effective Stratospheric Chlorine (EESC)) alone are able to give a good fit to ozone for Melbourne and, more generally, the southern mid-latitudes for most months of the year, in contrast with the case in the northern hemisphere where dynamical variation plays a much more important role. Correspondingly, the smoothed Melbourne Dobson time series shows a high correlation to EESC.
EVALUATION OF UNDRAINED SHEAR STRENGTH OF COHESIVE SOILS USING A FLAT DILATOMETER

The flat dilatometer (in-situ) testing device (DMT) has been used frequently North America and Europe during the short period of time since its introduction. The main advantages of the DMT are its simplicity, rapid and repetitive use for geotechnical engineering practice. This paper describes the use of the flat dilatometer (in-situ) testing device (DMT) in Japan. The discussion concentrates on the evaluation of undrained shear strength. Based on the limited available test data in Japan, an attempt has been made to determine the usefulness of Marchetti's equation related to undrained shear strength and to show the important modifications of the Marchetti's equations concerning the evaluation of undrained shear strength. In addition, a new equation has been developed to estimate the undrained shear strength cu obtained from an unconfined compression test to establish a Japanese design manual for clay foundations.
Lessons Learned from Ariel Data Challenge 2022 - Inferring Physical Properties of Exoplanets From Next-Generation Telescopes

Exo-atmospheric studies, i.e. the study of exoplanetary atmospheres, is an emerging frontier in Planetary Science. To understand the physical properties of hundreds of exo-planets, astronomers have traditionally relied on sampling-based methods. However, with the growing number of exoplanet detections (i.e. increased data quantity) and advancements in technology from telescopes such as JWST and Ariel (i.e. improved data quality), there is a need for more scalable data analysis techniques. The Ariel Data Challenge 2022 aims to find interdisciplinary solutions from the NeurIPS community. Results from the challenge indicate that machine learning (ML) models have the potential to provide quick insights for thousands of planets and millions of atmospheric models. However, the machine learning models are not immune to data drifts, and future research should investigate ways to quantify and mitigate their negative impact.