Miracle-dz/UniFAR-FTUs huggingface dataset:
Establishing a baseline: A social realist perspective on academic advising at a South African university prior to COVID-19

Academic advising remains an emerging practice and profession within the South African higher education sector. Although there has been an increase in literature about advising in South Africa recently, there remains a dearth of literature about the experiences of academic advisors working in this context. This article aims to make such a contribution, by focusing in particular on the experiences and insights from 15 South African advisors (from one university) about academic advising prior to the COVID-19 pandemic. The data that informs this study was collected through semi-structured interviews. The focus in this article is on advisor responses to three of the interview questions, which proved sufficient because of the richness of the data. The study draws on elements of social realist Margaret Archer’s (1995) morphogenetic framework to explicate why this perspective on advising within a South African higher education context is necessary. Archer’s (1995, 2005) work on structure, culture, and agency is then used as analytic lenses with which to analyse the advisors’ experiences and insights of advising prior to the pandemic. A phenomenographic approach (Marton 1981; Tight 2016) is adopted to explore the varying conceptions (Cibangu and Hepworth 2016) of advising offered by the academic advisors. Nine focal areas emerge from these insights, which are analysed and discussed using Archer’s (1995, 2005) structure, culture, and agency. It becomes apparent that academic advising was complex even before the pandemic. The advisors express an urgency to help others, raise concerns about entrenched inequities and resource constraints, highlight the pitfalls of inadequate help-seeking among students, and emphasise the need for better institutional integration of academic advising at the advisors’ university, among other things. It becomes clear that there are numerous structural and cultural tensions that constrain advisor and student agency, possibly to the detriment of student success. The article leaves the reader with insights into the experiences of academic advisors prior to the pandemic, thus providing a baseline against which to measure advising during and beyond the pandemic, at a time when advising in South African higher education is still being developed and defined.
Sexual Selection and Speciation

AbstractSexual selection has a reputation as a major cause of speciation, one of the most potent forces driving reproductive isolation. This reputation arises from observations that species differ most in traits involved with mating success and from successful models of sexual selection–driven speciation. But how well proven is the case? Models confirm that the process can occur, but is strongest in conjunction with ecological or niche specialization. Some models also show that strong sexual selection can act against speciation. Studies using the comparative method are equivocal and often inconclusive, but some phylogeographic studies are more convincing. Experimental evolution and genetic or genomic analyses are in their infancy, but look particularly promising for resolving the importance of sexual selection. The case for sexual selection is not as strongly supported as, for example, allopatric speciation. Sexual selection probably contributes most effectively alongside ecological selection or selection.
Association between serum vitamin D levels and sensitivity to thyroid hormone indices: a cross-sectional observational study in NHANES 2007–2012

Objective We designed this study to determine whether there is a link between vitamin D levels and sensitivity to thyroid hormone and to provide a new perspective for studying the relationship between vitamin D and thyroid disease. Methods Our study included 8,126 participators from the National Health and Nutrition Examination Survey (NHANES) database between 2007 and 2012. We used weighted multiple linear regression models to enquire the connection between serum vitamin D levels and thyroid hormone sensitivity indicators, including the following: Thyroid-stimulating hormone index (TSHI), Free Triiodothyronine/Free thyroxine (FT3/FT4), Thyroid Feedback Quantile-based Index (TFQI), and Thyrotroph Thyroxine Resistance Index (TT4RI). Finally, we used constrained cubic splines to explore possible nonlinear relationships. All data cleaning and statistical analyses were performed using R software. Results The final Results were reached after adjusting for various confounding factors. We found a U-shaped relationship between TFQI and serum vitamin D, and the lowest TFQI appeared when the serum vitamin D concentration was 25.77ng/ml. However, an inverse U-shaped relationship was found between FT3/FT4 and vitamin D levels. When the serum vitamin D concentration was 25.43ng/ml, the ratio of FT3/FT4 was the highest. Conclusion In the US population, our study concluded that FTQI and FT3/FT4 were U-shaped or inverse-U-shaped with serum vitamin D levels respectively after several adjustments. Therefore, FTQI and FT3/FT4 are considered indicators of the complex relationship between thyroid hormone resistance and vitamin D metabolism. In the future, more complex prospective investigations are needed to confirm these findings and find a causal link between them.
Nothing Ventured, Nothing Gained: A Meta-Analysis of CEO Overconfidence, Strategic Risk Taking, and Performance

Although overconfidence is acknowledged as one of the most common managerial decision-making biases, much uncertainty remains about its implications for firm performance. To resolve this uncertainty, we investigate how and why CEO overconfidence is related to firm performance using meta-analytic techniques on a sample of 199 studies. In particular, relying on behavioral decision theory, we develop alternative hypotheses regarding the impact of CEO overconfidence on firm performance. Contrary to the conventional belief that CEO overconfidence is detrimental, this study reveals that CEO overconfidence is, on average, beneficial for firm performance. Drawing on recent refinements of upper echelons theory and theoretical insights from the psychology literature, we then dive deeper into this positive relationship and hypothesize that overconfident CEOs engage in strategic risk taking through cognitive, motivational, and social mechanisms. This risk taking is positively related to firm performance. Our results confirm that the positive relationship between CEO overconfidence and firm performance is partially mediated through strategic risk taking. Thus, although CEO overconfidence is a cognitive bias, it does not automatically lead to inferior performance but can create value for firms by impelling CEOs to take actions that involve risk. We also test whether this relationship is stronger under conditions of high managerial discretion. Our results generally validate these predictions. Finally, on the basis of our findings, we discuss implications and directions for future CEO overconfidence research, including determining the limits of CEO overconfidence, exploring new moderators and mediators, and investigating the implications of different operationalizations of CEO overconfidence as well as the implications for practice.
Synthesis, Structural Elucidation, and Therapeutic Screening of Organotin(IV) derivatives of oxo-ethyl carbonodithioate

Exploring the therapeutic potential of organotin-based oxo-ethyl carbonodithioates, a series of organotin(IV) thiocarboamates (1-5) were synthesized with diverse alkyl and phenyl substituents. The chemical- composition, morphology, theoretical properties, and drug-DNA binding capabilities of the synthesized derivatives were performed by applying different characterization techniques like FT-IR, NMR (1H, 13C), AFM, DFT analysis, and UV-Vis spectroscopy respectively. The NMR data indicated six and four coordinated geometries, while the AFM results revealed smart surfaces concerning the grain size and root mean square (RMS) roughness, signifying catalytic and biocidal uses. The drug-DNA binding via intercalative mode of interaction with blue and red shifts was determined by using using UV spectroscopy. The in vitro biocidal capacity of selected complexes was evaluated against typical bacterial, fungal, cytotoxic, and leishmanial strains respectively. As a result of the surface and biocidal characterization, the synthesized complexes may be applied with greater potential in biomedical, pharmaceutical, infectious, catalysis, and cosmetics industries
Multimodel simulations revealed strong spatial heterogeneity in temperature‐, photoperiod‐ and moisture‐driven modes of autumn phenology in Northern Hemisphere grasslands (25° N–55° N)

Autumn phenology plays a critical role in regulating growing season length and matter and energy exchanges in terrestrial ecosystems. The climate‐driven mechanism of the grassland autumn phenology process and its spatial distribution patterns at the hemispheric scale are, however, still poorly understood. In this study, we employed 17 existing and modified models to simulate the satellite‐derived end‐of‐season (EOS) over northern mid‐latitude grasslands (25° N–55° N), aiming to determine how grassland autumn phenology responds to individual and combined changes in low temperature, photoperiod, and water supply. The results showed that the prediction accuracy of EOS based on models driven by daily minimum temperature is slightly superior to that of the counterparts forced by daily average temperature. The model modified with water content as a regulatory factor of leaf senescence rate determined by low temperature and photoperiod performed best (root‐mean‐square error, 10.4 days; correlation coefficient, 0.38) on average. The autumn phenology process in 68.4% of grassland areas was better simulated by the models that incorporated water conditions. Spatially, optimal models jointly forced by low temperature, photoperiod, and water supply occupied 61.4% of the North American grasslands, 58.5% of the Central‐West Asian grasslands, and 42.1% of the Mongolian grasslands. Grasslands on the Tibetan Plateau were primarily forced by the associated effects of low temperature and photoperiod. Further analysis revealed that low temperature‐photoperiod driven models and low temperature‐photoperiod‐moisture driven models were mostly distributed in relatively hotter and wetter grasslands, while optimal models forced solely by low temperature were largely concentrated in those grassland areas with cooler and drier autumn. Overall, this study highlights the complex patterns and spatial heterogeneity of environmental control on autumn phenology in the Northern Hemisphere grasslands, which could shed light on global grassland development investigation.
Obsessive–compulsive existential type: a dialectical-phenomenological approach

The clinical presentation of obsessive–compulsive patients is characterized by unwanted, intrusive, nonsensical, self-related, and recurrent ideas, thoughts, images, or impulses associated with active compulsive compensations. Under the operational diagnostic criteria adopted by the biological- and cognitive-oriented neopositivist medical paradigm, it is known as “obsessive–compulsive disorder. ” However, this paradigm has been criticized for its controversial assumptions, limited methodologies, theoretic biases, and inconsistency in producing practical outcomes. To bypass some of these issues, we propose a complementary approach that draws on and further develops existing psychopathological studies of the obsessive–compulsive anthropological condition based on dialectical phenomenological psychopathology. As such, we refer to the global clinical configuration as the “obsessive–compulsive existential type. ” Our theoretical inspiration comes from the classical phenomenological work on obsessions undertaken by Straus and Gebsattel, which identified the negative transformation of the obsessive–compulsive life-world or the endogenous emergence of the anti-eidos (diluting existential force). We then propose to broaden the concept of anti-eidos, especially in its dialectical correlation with eidos (unifying existential force), representing the existential dialectic between transformation and permanence. Next, we detail the dynamics of anthropological disproportions in obsessive–compulsive existential type, essentially the supremacy of the anti-eidos over the eidos. This primary imbalance modifies the obsessive–compulsive existential structure, consisting of polymorphic temporality; weakened intentionality; maladjusted calibration of distance with the world and others; an integral, isolated, besieged self with dwindling self-agency, and tense and over-protecting embodiment. We also analyze compensatory hyperreflexivity and compulsive rituals as expressions of structural counterbalancing designed to contain the primary structural disproportions and derangements. The heterogeneous obsessive–compulsive clinical manifestations are the complex result of the primary structural alteration and subsequent phenomenological compensations. They tend to be variable in temporal span and rarely assume a fixed form, hindering diagnosis. We correlate structural frameworks with multiple clinical examples. Finally, we raise some insights on how our study may contribute to scientific research and therapeutic proposals.
Perceptions of Islamic Banking among Post Millennials: A Study on Muslim Students

This study aimed to understand the perception of Islamic banking among post millennials Muslim students and explore their expectations towards Islamic Shariah compliant banking. The study uses qualitative method to understand respondents’ subjective views. Semi-structured interviews are used among the Muslim students studying at public and private universities in Malaysia. Twelve students were selected using purposive sampling. The analysis revealed that religious motives, efficient services, and convenience in terms of online banking and ATM services are factors in bank selection. The study found that the students’ perceptions of their understanding of Islamic banking are not sufficient, and there is a gap in the understanding of the mechanism of Islamic banking operations. Most of the existing literature is on the customer satisfaction, customer behaviour and service quality. However, there are little research on the perceptions of Islamic banking among the students who are post millennials. This study focus on the new generation’s perception of Islamic banking and attempts to fill this gap. The findings of the present study can be used as a reference in future studies in the area of perceptions among students or post millennials.
FuzDeMa: A portable fuzzy-based decision-making tool for reliable communication in wireless underground sensor networks

The deployment and the exploitation of a Wireless Underground Sensor Network (WUSN) remain challenging because of signal attenuation in the soil and the limited battery that powers the sensor nodes. Due to the attenuation of the signal in the ground, the reception or loss of the sent data depends on the ground conditions, which can change dynamically. However, in existing WUSNs, each node sends the data collected in each round regardless of the signal attenuation. It is well demonstrated that sensor nodes consume the most energy during transmission. Obviously, transmission without receiving any data significantly reduces the lifetime of a sensor node useless. This paper presents a novel fuzzy-based decision-making solution called FuzDeMa that reduces energy consumption by anticipating data losses before transmission. To do so, FuzDeMa assesses in real time the loss or the reception of a packet according to the in-situ node's environments before its transmission and decides whether to send or not the packet based on the computed reliability. To validate the proposed approach, we embed it into a dedicated underground node called the MoleNet and realized real experimentations firstly with an existing dataset and secondly, with precision-measuring equipment to estimate the energy consumption. The results revealed the possibility of prolonging the lifetime of the sensor node by saving up to 81.7876 microjoules in a single round. Additionally, FuzDeMa shows the ability to save energy for up to 46 of additional revolutions, thus extending the life of the sensor node to 32.85% for 140 real transmission cycles. An analytical generalization of FuzDeMa is provided regardless of a specific dataset or sensor node. Thus, we provided the conditions for a random dataset to save the energy with any sensor node that implements FuzDeMa during transmissions.
Head morphology reflects the introduction history in a globally invasive carnivore—the small Indian mongoose

Species displaced outside their native range may face new pressures resulting from both environmental gradients and important differences in ecosystem structure. We investigated how this may impact the morphological variation of a globally introduced carnivoran, the small Indian mongoose. Previous research showed size variations in several introduced populations, suggesting that these differences resulted from character release in response to the absence of competition from native species. Here, we contrasted the morphological evolution of indigenous and introduced populations using geometric morphometric approaches on the head system of a large sample of specimens belonging to several regions. Our analyses revealed that differences in size and shape between introduced and native populations do not support hypothesis of character release. These results suggest that morphological variations in introduced populations may reflect the introduction history of the species, rather than evolutionary processes resulting from changes in ecosystem composition.
Calpain signaling: from biology to therapeutic opportunities in neurodegenerative disorders

Neurodegenerative disorders represent a major and growing healthcare challenge globally. Among the numerous molecular pathways implicated in their pathogenesis, calpain signaling has emerged as a crucial player in neuronal dysfunction and cell death. Calpain is a family of calcium-dependent cysteine proteases that is involved in many biological processes, such as signal transduction, cytoskeleton remodeling, and protein turnover. Dysregulation of calpain activation and activity has been associated with several neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases. Understanding the intricate structure of calpains is crucial for unraveling their roles in cellular physiology and their implications in pathology. In addition, the identification of diverse abnormalities in both humans and other animal models with deficiencies in calpain highlights the significant progress made in understanding calpain biology. In this comprehensive review, we delve into the recent roles attributed to calpains and provide an overview of the mechanisms that govern their activity during the progression of neurodegenerative diseases. The possibility of utilizing calpain inhibition as a potential therapeutic approach for treating neuronal dysfunctions in neurodegenerative disorders would be an area of interest in future calpain research.
Clinicopathological Profile of Appendicular Disease in Children: A Tertiary Health Care Center Study

Background Acute appendicitis (AA) is the most common surgical emergency worldwide. Delay in diagnosis of disease often leads to serious complications such as perforation appendicitis (PA) and gangrenous appendicitis (GA). Aims and objectives The purpose of the study is to document clinicopathological outcomes in pediatric age group patients in a tertiary health care center. Material and method This study was a prospective observation study of 50 patients with pediatric appendicitis who had undergone emergency appendectomy from January 2022 to December 2022. All pediatric patients below 15 years of age with a diagnosis of AA were included. Institute ethical permission was granted before the study, and parent consent was taken for the surgery and also for inclusion in the study. After proper resuscitation, all patients underwent appendectomy, and necessary specimens were sent for histological examination. Based on histopathology reports, all patients were classified into four groups: AA, PA, GA, and normal appendix (NA). Results Out of 50 patients, 33 (66%) patients were males and 17 (34%) patients were females. The mean age of the patients was 10.22 ± 2.73 years. The mean age of AA, PA, GA, and NA patients were 10.25 ± 2.6 years, 9.78 ± 2.99 years, 10.00 ± 4.6 years, and 12.00 ± 2.8 years, respectively. The mean duration of symptoms at the time of hospital admission was 2.42 ± 0.97 days for histopathologically proven AA patients, 4.67 ± 2.1 days for GA patients, 2.8 ± 0.83 for PA patients, and one day for NA patients. Overall clinical presentation was right iliac fossa (RIF) pain in 36 (72%) patients, migration of pain in 31 (62%) patients, anorexia in 37 (74%) patients, nausea and vomiting in 43 (86%) patients fever in 26 (52%) patients, RIF tenderness in 50 (100%) patients, rebound tenderness in 39 (78%) patients, guarding in 19 (38%) patients, Psoas's sign in nine (18% patients), and Rovsing's sign in 19 (38%) patients. On histopathological examination of the sent specimen, AA was found in 36 (72%) patients, PA was found in nine (18%) patients, GA was found in three (6%) patients, and NA was found in two (4%) patients. Wound infection was the most common complication and was found in five (10%) patients. The average duration of hospital stay for AA, PA, GA, and NA was 4.33 ± 1.04 days, 9.56 ± 4.2 days, 12.33 ± 8.5 days, and 3.50 ± 0.71 days, respectively. Conclusion The appendicular disease is common in teenage male children. Fever, dehydration, and rebound tenderness at the RIF are clinically significant findings. Duration of symptoms at the time of diagnosis, post-appendectomy complication, and duration of hospital stay significantly correlated with histopathological findings.
Fibrinogen-Based Bioink for Application in Skin Equivalent 3D Bioprinting

Three-dimensional bioprinting has emerged as an attractive technology due to its ability to mimic native tissue architecture using different cell types and biomaterials. Nowadays, cell-laden bioink development or skin tissue equivalents are still at an early stage. The aim of the study is to propose a bioink to be used in skin bioprinting based on a blend of fibrinogen and alginate to form a hydrogel by enzymatic polymerization with thrombin and by ionic crosslinking with divalent calcium ions. The biomaterial ink formulation, composed of 30 mg/mL of fibrinogen, 6% of alginate, and 25 mM of CaCl2, was characterized in terms of homogeneity, rheological properties, printability, mechanical properties, degradation rate, water uptake, and biocompatibility by the indirect method using L929 mouse fibroblasts. The proposed bioink is a homogeneous blend with a shear thinning behavior, excellent printability, adequate mechanical stiffness, porosity, biodegradability, and water uptake, and it is in vitro biocompatible. The fibrinogen-based bioink was used for the 3D bioprinting of the dermal layer of the skin equivalent. Three different normal human dermal fibroblast (NHDF) densities were tested, and better results in terms of viability, spreading, and proliferation were obtained with 4 × 106 cell/mL. The skin equivalent was bioprinted, adding human keratinocytes (HaCaT) through bioprinting on the top surface of the dermal layer. A skin equivalent stained by live/dead and histological analysis immediately after printing and at days 7 and 14 of culture showed a tissuelike structure with two distinct layers characterized by the presence of viable and proliferating cells. This bioprinted skin equivalent showed a similar native skin architecture, paving the way for its use as a skin substitute for wound healing applications.