Miracle-dz/UniFAR-FTUs huggingface dataset:
Imaging GRPr Expression in Metastatic Castration-Resistant Prostate Cancer with [68Ga]Ga-RM2—A Head-to-Head Pilot Comparison with [68Ga]Ga-PSMA-11

Simple Summary Prostate cancer is the most prevalent cancer among men. Patients diagnosed with metastatic, castration-resistant prostate cancer (mCRPC) face a highly aggressive disease and reduced overall survival. For these patients, [177Lu]Lu-PSMA-617 has shown promising results. However, this therapy may not benefit patients with low or heterogeneous PSMA expression. The gastrin-releasing peptide receptor (GRPr) is highly expressed in prostate cancer and other cancer cells, and [177Lu]Lu-labeled GRPr-ligands have demonstrated good tumor uptake and retention, with minimal uptake in healthy tissues. However, the level of GRPr expression in advanced mCRPC patients remains elusive. In this study, we compared [68Ga]Ga-RM2 with [68Ga]Ga-PSMA-11 in a Latin American mCRPC cohort to evaluate the clinical utility of [68Ga]Ga-RM2 in this group of patients. Although GRPr is overexpressed in the early stages of prostate cancer, our results indicate that in more advanced stages, such as mCRPC, the expression is lower than PSMA. Abstract Background: The gastrin-releasing peptide receptor (GRPr) is highly overexpressed in several solid tumors, including treatment-naïve and recurrent prostate cancer. [68Ga]Ga-RM2 is a well-established radiotracer for PET imaging of GRPr, and [177Lu]Lu-RM2 has been proposed as a therapeutic alternative for patients with heterogeneous and/or low expression of PSMA. In this study, we aimed to evaluate the expression of GRPr and PSMA in a group of patients diagnosed with castration-resistant prostate cancer (mCRPC) by means of PET imaging. Methods: Seventeen mCRPC patients referred for radio-ligand therapy (RLT) were enrolled and underwent [68Ga]Ga-PSMA-11 and [68Ga]Ga-RM2 PET/CT imaging, 8.8 ± 8.6 days apart, to compare the biodistribution of each tracer. Uptake in healthy organs and tumor lesions was assessed by SUV values, and tumor-to-background ratios were analyzed. Results: [68Ga]Ga-PSMA-11 showed significantly higher uptake in tumor lesions in bone, lymph nodes, prostate, and soft tissues and detected 23% more lesions compared to [68Ga]Ga-RM2. In 4/17 patients (23.5%), the biodistribution of both tracers was comparable. Conclusions: Our results show that in our cohort of mCRPC patients, PSMA expression was higher compared to GRPr. Nevertheless, RLT with [177Lu]Lu-RM2 may be an alternative treatment option for selected patients or patients in earlier disease stages, such as biochemical recurrence.
DEVELOPMENT OF STUDENT LEARNING DISCIPLINES THROUGH THE ROLE OF THE SCHOOL ENVIRONMENT IN JAKARTA STATE HIGH SCHOOL STUDENTS

This study aims to determine the influence of learning motivation and self-efficacy on learning discipline with school environment moderation in class XI students of SMA Negeri 79 Jakarta. This research uses a quantitative approach with a questionnaire method. The total population in this study was 248, with a sample of 153 students using simple random sampling techniques. Data analysis is carried out by the SEM-PLS method. The results showed a positive and significant influence on learning motivation on learning discipline (r = 0.459, p-value = 0.000) and a positive and considerable influence of self-efficacy on learning discipline (r = 0.202, p-value = 0.00 6). The school environment does not moderate or does not affect the result of learning motivation on learning discipline (p-value = 0.184). The school environment does not make reasonable or does not affect the impact of self-efficacy on learning discipline (p-value = 0.506). These findings suggest that the school environment can not solely affect student learning discipline
Foliar Lesions Induced by Pestalotiopsis arengae in Oil Palm (O × G) in the Colombian Southwest Palm Zone

In Colombia, plantings with the oil palm hybrid between Elaeis oleifera × Elaeis guineensis, known as O × G hybrid, have increased due to its tolerance to bud rot. Despite this, different degrees of foliar necrosis, chlorosis, and leaf blight have been reported in some cultivars; therefore, this work aimed to diagnose this problem. We visited plantation plots with palms exhibiting the mentioned symptoms and collected 21 samples of affected tissues in different disease states. The affected tissues were examined and seeded in a culture medium. Pathogenicity tests were performed and the isolates were characterized by culture and morphological and molecular features. Curvularia, Colletotrichum, Phoma, and 25 Pestalotiopsis-like fungi were isolated from the foliar lesions. In the pathogenicity tests, the symptoms observed in the field were reproduced with MFTU01-1, MFTU12, and MFTU21 isolates, which were identified at the species level through a sequence analysis of three genes (ITS, TUB2, and TEF1-α) as Pestalotiopsis arengae with an identical level of 99% based on the results of BLAST and phylogenetic tree analyses. The remaining 22 Pestalotiopsis-like non-pathogenic isolates were identified as species of Neopestalotiopsis and Pseudopestalotiopsis. The direct association of P. arengae with the disease was confirmed via molecular detection in affected tissues in 15 of 21 samples collected for this evaluation. This is the first report of P. arengae as the causal agent of foliar lesions in O × G hybrid oil palm in Colombia.
The economic impact of natural disasters in Fiji

There has been relatively little research on the economic impacts of natural disasters to date. This paper reports fmdings of a study of Fiji which is intended as a contribution in filling that gap. Findings include the following: • Severe natural disasters constitute major exogenous shocks to the Fijian economy, resulting in substantial declines in GDP. • Both the manufacturing and agricultural sectors, as well as overall GDP, have become increasingly vukierable to natural disasters since the early 1980s. Current changes in the agricultural sector suggest that its vulnerability to natural disasters could increase further in the shortto medium-term. However, the vulnerability of the manufacturing sector looks set to decline. • Severe natural disasters have had profound budgetary implications. • The balance of payments has been relatively immune to natural disasters, primarily reflecting higher reinsurance flows as well as the use of sugar reserves to further boost eamings in the event of a disaster. However, anticipated diversification out of sugar production could increase the exposure of the balance of payments. • Considerable attention has been paid to disaster management, particularly preparedness and post-disaster activities. Much less effort has been made to incorporate hazard risks into broader economic strategic planning or to mitigate the economic impacts, specifically, of disasters. • There has been a gradual breakdown in traditional mitigation and coping mechanisms and communities have increasingly turned to the government for assistance in the aftermath of disasters.
Performance and industry level implication of organisations’ strategic personality

This exploratory study investigates how an organisation’s strategic personality can be inferred through linguistic and machine learning approaches and its performance and industry-level implications. The study uses 820 chief executive officers’ (CEOs) statements published in annual reports of the Australian Stock Exchange (ASX) listed companies in Australia with the personality insight service on the IBM Watson platform to infer the strategic personalities of firms. By applying unsupervised clustering on the extracted values of personality traits, the study found two distinct and reliable clusters of personalities: a bright and a lighter shade of dark personalities, which are differently associated with the indicators of firms’ performance and industry categories. While contributing to the advancement of performance-personality research and their measurement at the organisational level, this study opens a new avenue for the adoption of unobtrusive linguistic techniques and data sources for strategic personality-performance research in the corporate governance disciplines. Limitations of the present study and suggestions for future research are also discussed.
Impact of Poor Oral Health Status on Swallowing Function Improvement in Older Dysphagic Patients

Background This study aimed to explore the relationship between poor oral health status and improvement in swallowing function in older patients with dysphagia across various clinical settings, including acute and post-acute care environments. Methods This retrospective cohort study encompassed patients aged 65 years and older with dysphagia. Oral health status was assessed using the oral health assessment tool (OHAT) or the revised oral assessment guide (ROAG). In this study, an OHAT score of ≥3 or an ROAG score of ≥13 indicated poor oral health status. The primary outcome measured was the change in the food intake level scale (FILS) score, which reflects swallowing function, during the observation period. The association between changes in FILS score and poor oral health status was analyzed using a multivariable linear regression model. Results The study included 361 older patients with dysphagia (mean age 82.7 ± 7.7 years; 47.3% male), of whom 82.5% had poor oral health. A negative association was found between poor oral health status and improvement in FILS score at the endpoint (partial regression coefficient: -0.523, 95% confidence interval: -0.99 to -0.06, P=0.026). Conclusions Our findings underscore the negative impact of poor oral health status on the improvement of swallowing function and emphasize the importance of oral health interventions for older patients. Further study on oral health interventions' effects on improving swallowing function in older patients with dysphagia is warranted.
Fruit and Vegetable Consumption during the COVID-19 Lockdown in Serbia: An Online Survey

The global impact of the COVID-19 pandemic has significantly influenced individuals’ dietary choices and food-buying behavior. Present research specifically delves into the alterations in fruit and vegetable (F&V) consumption among consumers in Serbia during the pandemic. The study employs an extended model of the theory of planned behavior (TPB), incorporating the construct of consumers’ knowledge to comprehensively explore behavioral changes. Conducted in the first half of 2020, the study engaged 479 participants from Serbia, using an online questionnaire for data collection. Structural equation modelling was employed for a thorough analysis of the gathered responses. The main outcome revealed a noteworthy connection between consumers’ knowledge and their attitudes, subjective norms, and intentions regarding F&V consumption. Subjective norms significantly influenced consumers’ desire to increase F&V intake during and after the outbreak. These intentions aligned with actual behavior changes, indicating a shift toward higher F&V consumption. Consumer knowledge also notably shaped attitudes and behaviors regarding F&V intake. Notably, the TPB proved valuable in predicting and understanding these dietary shifts during global crises like the pandemic. These insights not only bolster healthier eating habits but also have broader implications for public health. Understanding consumer behavior dynamics during crises like COVID-19 is crucial for crafting effective strategies to promote overall human health and well-being.
Boron Foliar Application Improves Growth, Yield
and Grain Quality of Maize

Balanced nutrition is the key to higher quality crop production. Micronutrients, especially boron (B) have an important role in various physiological processes and stress tolerance while its deficiency could affect the yield and quality of crop plants. In this context, this study investigated the significance of foliar B application at various growth stages on maize yield components, yield, and grain B content. The treatments consisted of boron foliar application levels (0, 0.5, 1, 1.5 and 2%) at different growth stages (V4 = fourth leaf stage, V8 = eighth leaf stage and VT = tasseling stage) during summer 2021 and 2022. The results revealed that plant height, leaf area plant -1 , leaf area index, plants at harvest, ear length, grains ear -1 , thousand grains weight, shelling percentage, biological yield, grain yield and harvest index were increased with 1 % B foliar spray compared to other levels. In addition, ear length, grains ear -1 , thousand grains weight, shelling percentage, biological yield, grain yield and harvest index were increased with B foliar application at VT (tasseling stage) compared to other stages. It was concluded that the application of 1% foliar boron (1.28 kg B ha -1 ) i.e. 7.32 kg H 3 BO 3 at tasseling stage improved growth, yield and yield components of maize.
Oleuropein Stimulates Migration of Human Trophoblast Cells and Expression of Invasion-Associated Markers

Successful pregnancy establishment requires highly synchronized cross talk between the invasive trophoblast cells and the receptive maternal endometrium. Any disturbances in this tightly regulated process may lead to pregnancy complications. Local factors such as nutrients, hormones, cytokines and reactive oxygen species modulate the invasion of extravillous trophoblasts through critical signaling cascades. Epidemiological studies strongly indicate that a Mediterranean diet can significantly impact molecular pathways during placentation. Therefore, the aim of the current study was to examine whether oleuropein (OLE), one of the main compounds of the Mediterranean diet, may influence trophoblast cell adhesion and migration, as well as the expression of invasion-associated molecular markers and inflammatory pathways fostering these processes. HTR-8/SVneo cells were incubated with OLE at selected concentrations of 10 and 100 µM for 24 h. Results showed that OLE did not affect trophoblast cell viability, proliferation and adhesion after 24 h in in vitro treatment. The mRNA expression of integrin subunits α1, α5 and β1, as well as matrix-degrading enzymes MMP-2 and -9, was significantly increased after treatment with 10 µM OLE. Furthermore, OLE at a concentration of 10 µM significantly increased the protein expression of integrin subunits α1 and β1. Also, OLE inhibited the activation of JNK and reduced the protein expression of COX-2. Finally, a lower concentration of OLE 10 µM significantly stimulated migration of HTR-8/SVneo cells. In conclusion, the obtained results demonstrate the effects of OLE on the function of trophoblast cells by promoting cell migration and stimulating the expression of invasion markers. As suggested from results, these effects may be mediated via inhibition of the JNK signaling pathway.
Elastofibroma Dorsi Detected Incidentally on Chest Computed Tomography: The Prevalence and Reporting Rate in Radiology Reports

Background Elastofibroma dorsi (ED) is an uncommon benign connective-tissue tumor, usually seen in the subscapular region of women after the fifth decade. The study aimed to determine the prevalence, radiological characteristics, and the rates of mention in the initial radiology reports of ED incidentally detected by chest computed tomography (CT) imaging in a large population. Methodology This study was conducted at Hitit University, Erol Olçok Training and Research Hospital Radiology Department in Çorum, Turkey. A total of 3,299 patients (1,554 females, 1,745 males) who underwent non-contrast chest CT for various reasons were included in this retrospective study. The presence, side, thickness, and density of ED were investigated in these patients. Differences in gender and laterality were assessed statistically. It was also reviewed whether it was stated in the initial radiology report or not. Results ED was detected in 79 (2.4%) of 3,299 patients, in 60 (75.9%) females and 19 (24.1%) males with a median age of 57.5 years (range, 18-99 years). The risk of ED presence was determined to be 3.65-fold in females than in males. In the cases determined with ED, the median age was 75 years (range, 53-96 years), and ED was not determined in any patient aged <50 years. A statistically significant correlation was determined between age and the presence of ED (p < 0.001). No statistically significant correlation was found between age and ED thickness or density (p = 0.602, p = 0.233, respectively). It was noted that none of the patients were diagnosed in the first radiological report. Conclusions ED can be easily overlooked on cross-sectional examinations because of the similar appearance and density to adjacent structures. Knowledge of the characteristic radiological features of these lesions and increased awareness of radiologists will make early diagnosis possible in asymptomatic cases.
IoT Fog Computing Optimization Method Based on Improved Convolutional Neural Network

The rapid development of communication technology has promoted the development of the Internet of Things technology. It has resulted in a scarcity of computing resources for the Internet of Things devices, and limited the further development of the Internet of Things. In order to improve the utilization efficiency of the system resources for the Internet of Things devices and promote the further development of the Internet of Things, the continuous Markov decision process model is constructed. The value function approximation algorithm of the convolutional neural network is used to solve the problem. Continuous Markov decision process model is an excellent single-user decision process model, but not optimal for multi-user systems. Using convolutional neural network to solve the value function of continuous Markov decision process model, so that it can be applied to multi-user system. The results show that the average algorithm has growth rates of 0.48 and 0.84, respectively, in comparison to the other two algorithms. The average arrival rate has the least effect on the average delay of the value function approximation algorithm and the greatest influence on its power consumption. With the average arrival rate, the average delay of the algorithm increased by 0.25S and the power consumption by 0.27W. The effectiveness of the value function approximation algorithm based on convolutional neural network surpasses that of the multi-user multi-task offloading algorithm and the queue-aware algorithm, thus applying continuous Markov decision process models to multi-user systems. The study combines the continuous Markov decision process model with the resource decision of IOT devices, resulting in optimized resource scheduling decisions and improved utilization efficiency of IOT devices.
Cloning and Expression of Mannheimia haemolytica PlpE Gene in Escherichia coli and its Immunogenicity Assessment.

Mannheimia haemolytica is responsible for considerable economic losses to cattle, sheep, and goat industries in many parts of the world. This bacterium isone of the causative agents of shipping fever in cattle. Current vaccines against M. haemolytica are moderately efficacious since they do not provide complete protection against the disease. Production of an economic vaccine for protecting farm animals against M. haemolytica has attracted the attention of many scientists. The outer membrane proteins (OMPs) play a major role in the pathogenesis and immunogenicity of M. haemolytica. Research on M. haemolytica OMPs has shown that antibodies to a particular OMP may be important in immune protection. In the current study, the gene for M. haemolytica OMP PlpE was cloned into the expression vector pET26-b, and then expressed in Escherichia coli BL21. The expression of the protein was carried out by the induction of cultured Escherichiacoli Bl21 cells with 1mM isopropyl-β-D-thiogalactopyranoside. The recombinant PlpE was purified using Ni-NTA agarose resin, and then subjected to sodium dodecyl sulfate polyacrylamide gel electrophoresis. The identity of the expressed protein was analyzed by western blotting. It was revealed that rPlpE was expressed and produced properly. To assess the immunogenicity of the recombinant protein, the purified rPlpE was used as an antigen for antibody production in goats. The observations suggested that the produced recombinant protein can be used as a antigen for developing diagnostic tests and or as a vaccine candidate.
Sedimentary provenance constraints on drainage evolution models for SE Tibet: Evidence from detrital K‐feldspar

The unusual drainage pattern of the Jinsha River (upper Yangtze) is closely linked to the uplift of the Tibetan Plateau, but when this pattern became established is controversial. In this study we compare the Pb isotopic composition of detrital K‐feldspars from the modern Jinsha River with those from the Plio‐Pleistocene Xigeda Formation, a sequence of fluvial and lacustrine deposits widely distributed along the major rivers draining the Tibetan Plateau, to investigate their relationship and to constrain the drainage evolution of the region. Our results demonstrate that the Jinsha River had achieved its current sediment‐transport pattern by the late Pliocene, indicating a drainage character similar to that operating at present. Our findings not only suggest an upper age limit for formation of the Jinsha River but also shed new light on the evolution of the whole Yangtze system. K‐feldspar grains from the Jinsha River have less radiogenic Pb than those in the Red, Mekong, and Salween Rivers, providing a key test as to whether the Jinsha River was previously connected to the paleo‐Red River. Comparison with published Pb isotopic data shows that these characteristically unradiogenic feldspars are absent in the onshore Cenozoic archive from the Hanoi Basin, suggesting that there has been no connection between the lower Jinsha River and the Red River since the Eocene.
Design of a Novel Mid-Infrared Single-Polarization Single-Mode Photonic Crystal Fiber with Low Loss, High Nonlinearity, and Large Bandwidth

ABSTRACT A novel mid-infrared Ge20Sb15Se65 chalcogenide-based single-polarization single-mode (SPSM) photonic crystal fiber (PCF) with rectangular latticed circular air holes is proposed. The properties of SPSM bandwidth, confinement loss, and nonlinearity are analyzed in the 3 μm~8 μm mid-infrared region using the finite -difference time-domain (FDTD) method. The influences of different geometrical parameters on the properties of SPSM-PCF are analyzed. All numerical computational results reveal that for the optimized geometrical parameters, the proposed PCF can deliver a SPSM region of more than 2.3814 μm with high nonlinearity of 3,705 w−1 km−1. Therefore, such a SPSM-PCF will become an excellent candidate for mid-infrared photonic.