Miracle-dz/UniFAR-FTUs huggingface dataset:
ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones

E-cadherin plays a powerful tumor suppressor role. Germline E-cadherin mutations justify 30% of Hereditary Diffuse Gastric Cancer (HDGC) and missense mutations are found in 30% of these families. We found possible to restore in vitro mutant E-cadherin associated to HDGC syndrome by using Chemical Chaperones (CCs). Herein, our aim was to disclose the molecular mechanisms underlying the CCs effects in E-cadherin regulation. Using cells stably expressing WT E-cadherin or two HDGC-associated missense mutations, we show that upon DMSO treatment, not only mutant E-cadherin is restored and stabilized at the plasma membrane (PM), but also Arf6 and PIPKIγ expressions are altered. We show that modulation of Arf6 expression partially mimics the effect of CCs, suggesting that the cellular effects observed upon CCs treatment are mediated by Arf6. Further, we show that E-cadherin expression recovery is specifically linked to Arf6 due to its role on endocytosis and recycling pathways. Finally, we demonstrated that, as DMSO, several others CCs are able to modulate the trafficking machinery through an Arf6 dependent mechanism. Interestingly, the more effective compounds in E-cadherin recovery to PM are those that simultaneously inhibit Arf6 and stimulate PIPKIγ expression and binding to E-cadherin. Here, we present the first evidence of a direct influence of CCs in cellular trafficking machinery and we show that this effect is of crucial importance in the context of juxtamembrane E-cadherin missense mutations associated to HDGC. We propose that this influence should be taken into account when exploring the therapeutic potential of this type of chemicals in genetic diseases associated to protein-misfolding.
Prevalence and Predictors of Vitamin D Insufficiency in Children: A Great Britain Population Based Study

Objectives To evaluate the prevalence and predictors of vitamin D insufficiency (VDI) in children In Great Britain. Design A nationally representative cross-sectional study survey of children (1102) aged 4–18 years (999 white, 570 male) living in private households (January 1997–1998). Interventions provided information about dietary habits, physical activity, socio-demographics, and blood sample. Outcome measures were vitamin D insufficiency (<50 nmol/L). Results Vitamin D levels (mean = 62.1 nmol/L, 95%CI 60.4–63.7) were insufficient in 35%, and decreased with age in both sexes (p<0.001). Young People living between 53–59 degrees latitude had lower levels (compared with 50–53 degrees, p = 0.045). Dietary intake and gender had no effect on vitamin D status. A logistic regression model showed increased risk of VDI in the following: adolescents (14–18 years old), odds ratio (OR) = 3.6 (95%CI 1.8–7.2) compared with younger children (4–8 years); non white children (OR = 37 [95%CI 15–90]); blood levels taken December-May (OR = 6.5 [95%CI 4.3–10.1]); on income support (OR = 2.2 [95%CI 1.3–3.9]); not taking vitamin D supplementation (OR = 3.7 [95%CI 1.4–9.8]); being overweight (OR 1.6 [95%CI 1.0–2.5]); <1/2 hour outdoor exercise/day/week (OR = 1.5 [95%CI 1.0–2.3]); watched >2.5 hours of TV/day/week (OR = 1.6[95%CI 1.0–2.4]). Conclusion We confirm a previously under-recognised risk of VDI in adolescents. The marked higher risk for VDI in non-white children suggests they should be targeted in any preventative strategies. The association of higher risk of VDI among children who exercised less outdoors, watched more TV and were overweight highlights potentially modifiable risk factors. Clearer guidelines and an increased awareness especially in adolescents are needed, as there are no recommendations for vitamin D supplementation in older children.
Deep Stack Dictionary learning for Fault Diagnosis of Rotating Machinery

Effective feature extraction of rotating machinery has been a hot topic in the prognosis and health management. However, it is a challenging problem to extract periodic impulses under heavy background noise and other interference. In the last decade, deep learning and dictionary learning have been promising methods to extract feature information, which have made great achievement in the field of image, video denoising, etc. In this paper, via fusing the deep learning with dictionary learning, an algorithm called deep stack dictionary learning is proposed. This algorithm is trained in a layer-wise greedy manner so as to suppress the noise and highlight periodic impulses.
Bottle-feeding and the Risk of Pyloric Stenosis

OBJECTIVES: Bottle-feeding has been suggested to increase the risk of pyloric stenosis (PS). However, large population-based studies are needed. We examined the effect of bottle-feeding during the first 4 months after birth, by using detailed data about the timing of first exposure to bottle-feeding and extensive confounder information. METHODS: We performed a large population-based cohort study based on the Danish National Birth Cohort, which provided information on infants and feeding practice. Information about surgery for PS was obtained from the Danish National Patient Register. The association between bottle-feeding and the risk of PS was evaluated by hazard ratios (HRs) estimated in a Cox regression model, adjusting for possible confounders. RESULTS: Among 70 148 singleton infants, 65 infants had surgery for PS, of which 29 were bottle-fed before PS diagnosis. The overall HR of PS for bottle-fed infants compared with not bottle-fed infants was 4.62 (95% confidence interval [CI]: 2.78–7.65). Among bottle-fed infants, risk increases were similar for infants both breast and bottle-fed (HR: 3.36 [95% CI: 1.60–7.03]), formerly breastfed (HR: 5.38 [95% CI: 2.88–10.06]), and never breastfed (HR: 6.32 [95% CI: 2.45–16.26]) (P = .76). The increased risk of PS among bottle-fed infants was observed even after 30 days since first exposure to bottle-feeding and did not vary with age at first exposure to bottle-feeding. CONCLUSIONS: Bottle-fed infants experienced a 4.6-fold higher risk of PS compared with infants who were not bottle-fed. The result adds to the evidence supporting the advantage of exclusive breastfeeding in the first months after birth.
TR 03-020 TAPER : An Efficient Two-Step Approach for All-Pairs Correlation Query in Transaction Databases

Given a user-specified minimum correlation threshold and a transaction database with items, all-strongpairs correlation query finds all item pairs with correlations above the threshold . However, when the number of items and transactions are large, the computation cost of this query can be very high. In this paper, we identify an upper bound of Pearson’s correlation coefficient for binary variables. This upper bound is not only much cheaper to compute than Pearson’s correlation coefficient but also exhibits a special monotone property which allows pruning of many item pairs even without computing their upper bounds. A Two-step All-strong-Pairs corrElation queRy (TAPER) algorithm is proposed to exploit these properties in a filterand-refine manner. Furthermore, we provide an algebraic cost model which shows that the computation savings from pruning is independent or improves when the number of items is increased in data sets with common Zipf or linear rank-support distributions. Experimental results from synthetic and real data sets exhibit similar trends and show that the TAPER algorithm can be an order of magnitude faster than brute-force alternatives.
Nonparametric Assessment of Contamination in Multivariate Data Using Minimum Volume Sets and FDR

Large, multivariate datasets from high-throughput instrumentation have become ubiquitous throughout the sciences. Frequently, it is of great interest to characterize the measurements in these datasets by the extent to which they represent ‘nominal’ versus ‘contaminated’ instances. However, often the nature of even the nominal patterns in the data are unknown and potentially quite complex, making their explicit parametric modeling a daunting task. In this paper, we introduce a nonparametric method for the simultaneous annotation of multivariate data (called MN-SCAnn), by which one may produce an annotated ranking of the observations, indicating the relative extent to which each may or may not be considered nominal, while making minimal assumptions on the nature of the nominal distribution. In our framework each observation is linked to a corresponding minimum volume set and, implicitly adopting a hypothesis testing perspective, each set is associated with a test, which in turn is accompanied by a certain false discovery rate. The combination of minimum volume set methods with false discovery rate principles, in the context of contaminated data, is new. Moreover, estimation of the key underlying quantities requires that a number of issues be addressed. We illustrate MN-SCAnn through examples in two contexts – the pre-processing of cell-based assays in bioinformatics, and the detection of anomalous traffic patterns in Internet measurement studies.
Heavy mineral resource potential of Tista river sands, Northern Bangladesh

Surface and borehole sampling along a ∼80 km section of the lower Tista river, northwestern Bangladesh, indicated that the river sands offer significant potential as a heavy mineral (HM) resource. Characterisation of sediments from the surface to 15 m depth showed that the sand-sized component was dominated by quartz, feldspar, mica, lithic fragments, amphibole and pyroxene group minerals. The most common particle size was between +125–500 μm with 84 wt-% of all material reporting to this size range. Laterally spaced sampling indicated slight grain size coarsening upstream. Heavy liquid separation studies revealed that HMs such as amphiboles, micas, garnets, aluminosilicate (Al2SiO5) phases, ilmenite and zircon made up ∼10.99% (on average). The percentage of valuable HMs (ilmenite, rutile, zircon, monazite, garnet) was 2.47% (average). Detailed borehole sampling and resource mapping of a large, mid-channel sand bar showed that placer-style HM accumulations occur upstream and along the margins of the bar.
Quality and Fairness of an Information Security Policy As Antecedents of Employees' Security Engagement in the Workplace: An Empirical Investigation

This paper investigates the impact of the characteristics of information security policy (ISP) on an employee's security compliance in the workplace. Two factors were proposed as the antecedents of employees' security compliance: ISP Fairness and ISP Quality. ISP Quality is comprised of three quality dimensions--Clarity, Completeness, and Consistency. It is shown that ISP fairness has a strong positive effect on an employee's ISP Compliance. In addition, it is found that ISP quality does not only have a strong positive influence on an employee's ISP compliance but also have a strong influence on an employee's perceived ISP fairness. This study contributes to the literature by highlighting the importance of ISP characteristics; namely, ISP quality and ISP fairness as an organizational resource to enhance an organization's information security.
Experimental Study on Behavior Acquisition of Mobile Robot by Deep Q-Network

∗Graduate School of Information Science, Nara Institute of Science and Technology 8916-5 Takayama-cho, Ikoma, Nara 630-0192, Japan E-mail: sasaki.hikaru. rw3@is.naist. ac.jp ∗∗Department of Control Engineering, National Institute of Technology, Matsue College 14-4 Nishi-ikuma, Matsue, Shimane 690-8518, Japan E-mail: horiuchi@matsue-ct.ac.jp ∗∗∗Department of Information Engineering, National Institute of Technology, Matsue College 14-4 Nishi-ikuma, Matsue, Shimane 690-8518, Japan E-mail: kato@matsue-ct.ac.jp
A technique of awake fibreoptic intubation

We report our experience of 58 patients undergoing awake fibreoptic intubation for cervical spine surgery. Topical anaesthesia was administered using a ‘spray as you go’ technique. The tracheas of 57 patients were intubated successfully. The mean time from starting topical anaesthesia to intubation was 16. l min (SEM 1.0). The procedure was associated with cardiovascular stability, a low incidence of severe cough and had a high patient acceptance. There was a low failure rate amongst trainees. The minimum mean arterial oxygen saturation was 92.9% (SEM 1.1). There was no relationship between the time taken to intubation and the episodes of desaturation or the grade oflaryngeal visibility at direct laryngoscopy. This method of producing topical anaesthesia for awake fibreoptic intubation is recommended.
Tumour necrosis factor‐α contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia

It has been demonstrated that tumour necrosis factor‐alpha (TNF‐α) via its receptor 2 (TNFR2) plays a role in the cardioprotective effects of preconditioning. It is also well known that chronic hypoxia is associated with activation of inflammatory response. With this background, we hypothesized that TNF‐α signalling may contribute to the improved ischaemic tolerance of chronically hypoxic hearts.
The research of intelligent method for blurring image reconstruction

The restoration methods of foggy blurring image and fast movement blurring image are researched in this paper. Hue saturation adjustment method, Retinex method and the dark channel prior method are all used for restoring foggy blurring image. POCS method and bicubic interpolation methods are all used for restoring fast movement blurring image. The experimental results show that the restoration image of foggy degradation image obtained by using dark channel prior method is better than the ones obtained by Retinex algorithm and hue saturation adjustment method, in which the color and detail information are all recovered well; POCS and bicubic interpolation super-resolution methods can all recover lots of information lost in low-resolution images, suitable for high-resolution reconstruction image.
Spine curve modeling for quantitative analysis of spinal curvature

Spine curvature and posture are important to sustain healthy back. Incorrect spine configuration can add strain to muscles and put stress on the spine, leading to low back pain (LBP). We propose new method for analyzing spine curvature in 3D, using CT imaging. The proposed method is based on two novel concepts: the spine curvature is derived from spinal canal centerline, and evaluation of the curve is carried out against a model based on healthy individuals. We show results of curvature analysis of healthy population, pathological (scoliosis) patients, and patients having nonspecific chronic LBP.
The dilemmas of risk-sensitive development on a small volcanic island

In the Small Islands Developing State (SIDS) of St Vincent and the Grenadines in the Caribbean, the most destructive disasters in terms of human casualties have been the multiple eruptions of La Soufriere volcano situated in the north of St Vincent. Despite this major threat, people continue to live close to the volcano and national development plans do not include risk reduction measures for volcanic hazards. This paper examines the development options in volcanic SIDS and presents a number of conundrums for disaster risk management on the island of St Vincent. Improvements in monitoring of volcanic hazards and ongoing programmes to enhance communications systems and encourage community preparedness planning have increased awareness of the risks associated with volcanic hazards, yet this has not translated into more risk-informed development planning decisions. The current physical development plan in fact promotes investment in infrastructure in settlements located within the zone designated very high-hazard. However, this is not an anomaly or an irrational decision: severe space constraints in SIDS, as well as other historical social and economic factors, limit growth and options for low-risk development. Greater attention needs to be placed on developing measures to reduce risk, particularly from low-intensity hazards like ash, limiting where possible exposure to volcanic hazards and building the resilience of communities living in high-risk areas. This requires planning for both short- and longer-term impacts from renewed activity. Volcanic SIDS face multiple hazards because of their geography and topography, so development plans should identify these interconnected risks and options for their reduction, alongside measures aimed at improving personal preparedness plans so communities can learn to live with risk.
Comparison between graph-based and interference-based STDMA scheduling

Spatial reuse TDMA is a fixed assignment access scheme for multi-hop radio networks. The idea is to increase network capacity by letting several radio terminals use the same time slot when the interferences caused are not too severe. We consider two methods of generating traffic controlled reuse schedules. One method uses full knolwedge of the interference environment to generate schedules. The other method uses a graph representation of the network, assuming limited knowledge of the interferences. By simulations, we evaluate the proposed methods in terms of average delay and throughput. The simulation results indicate that the network performance of the graph-based scheduling may suffer compared to the interference-based scheduling, depending on how the graph is created. In a stationary situation, or temporary stationary situation, where knowledge of the full interference environment can be assumed, interference based scheduling can improve the network capacity by up to one thrid, thereby being worth its increased complexity
THE DEVELOPMENT OF A MEANINGFUL HACKER TAXONOMY : A TWO DIMENSIONAL APPROACH by mkr

The current paper extends and matures the earlier taxonomy framework of the author (Rogers, 1999), and provides a preliminary two dimensional classification model. While there is no one generic profile of a hacker, studies indicate that there are at least eight primary classification variables: Novices (NV), Cyber-Punks (CP), Internals (IN), Petty Thieves (PT), Virus Writers (VW), Old Guard hackers (OG), Professional Criminals (PC), and Information Warriors (IW), and 2 principal components, skill and motivation. Due to the complex nature and interactions of these variables and principal components, the traditional one-dimensional continuum is inadequate for model testing. A modified circular order circumplex is presented as a better method for developing a preliminary hacker taxonomy. The paper discusses the importance of developing a meaningful understanding of the hacker community and the various sub-groups. Directions for future research are also discussed.
Effect of elevated temperature regimes on growth and yield of wheat (Triticum aestivum) and its mitigation by agronomic management techniques

A field experiment was conducted within a temperature gradient tunnel (TGT: 30m x 5m x 3m) to investigate the effect of elevated temperature regimes on growth and yield of wheat (Triticum aestivum) and its mitigation by agronomic management techniques at the Research Farm, School of Climate Change and Agricultural Meteorology, PAU, Ludhiana during rabi, 2015-16. The experiment comprised of 54 treatments combinations viz. 6 temperature regimes (+3.0, +3.2, +3.3, +3.5 and +3.6 o C), 3 wheat cultivars (WH-1105, PBW-550 and HD2967) and 3 foliar spray treatment (No foliar spray, Water spray and Urea spray 3%). The data on micrometeorological parameters, phenology, periodic growth parameters, yield and yield attributes of wheat cultivars were recorded. The foliar spray of urea 3% and foliar spray of water were applied at the late jointing and grain filling stage. The results of the study indicate that plant height and spikelet sterility increased but grain and straw yield of wheat decreased significantly with rise in temperature within the TGT. The partitioning of photosynthates among the grain and straw yield were severely affected as is indicated by the changes in harvest index. Amongst the spray treatment, the urea spray reduced the negative effect of rise in temperature more effectively as compared to water and no spray treatment. The increase in rate of spikelet sterility, plant height and decrease in rate of yield / yield attributes of wheat cultivars was mitigate effectively by the urea spray treatment. The yield and yield attributes at elevated temperature regimes was decreased maximum in cv. PBW-550 followed by cv. WH-1105 and cv. HD-2967 from ambient conditions. Amongst the wheat cultivars, HD-2967 was most tolerant and PBW-550 was most susceptible to an increase in temperature. The results of the study indicate that under anticipated increase in temperature, cv. HD-2967 may be recommended for cultivation due to its tolerant growth traits towards maintaining its yield and yield attributes under high temperature condition which are the most important determinants of high productivity of a cultivar.
Gastroenterología y Hepatología

Cirrhotic patients often develop severe complications requiring ICU admission. Grade III---IV hepatic encephalopathy, septic shock, acute-on-chronic liver failure and variceal bleeding are clinical decompensations that need a speciﬁc therapeutic approach in cirrhosis. The increased effectiveness of the treatments currently used in this setting and the spread of liver transplantation programmes have substantially improved the prognosis of critically ill cirrhotic patients, which has facilitated their admission to critical care units. However, gastroenterologists and intensivists have limited knowledge of the pathogenesis, diagnosis and treatment of these complications and of the prognostic evaluation of critically ill cirrhotic patients. Cirrhotic patients present alterations in systemic and splanchnic haemodynamics, coagulation
Robust super-exponential methods for blind equalization of an SISO-IIR system with additive Gaussian noise

The present paper deals with the blind equalization problem of a single-input single-output infinite impulse response (SISO-IIR) system with additive Gaussian noise. To solve the problem, we propose a ”super-exponential method” (SEM). The novel point of the proposed SEM is that even when Gaussian noise is added to the output of the system, the blind equalization can be achieved with as little influence of Gaussian noise as possible; hence the proposed SEM is referred to as a ”robust super-exponential method” (RSEM). Simulation results show the validity of the proposed RSEM.
Simultaneous online identification of rational dynamics and time delay: a correlation-based approach

A new algorithm for simultaneous identification of a rational dynamic and an unknown or varying time delay is suggested in this communication. The proposed method is based on integration of two interacting estimation modules: First, a pseudo-pure delay system is obtained by filtering the input and output of the system. The time-delay is then identified via correlation technique. The rational dynamics is identified via standard recursive least-squares identification. An experimental study is included to illustrate the merits of this algorithm.