Miracle-dz/UniFAR-FTUs huggingface dataset:
Analisis Variabel-Variabel yang Mempengaruhi Laba Usaha Mikro Kecil dan Menengah (UMKM) (Studi Kasus Sentra Usaha Kripik Pisang Kabupaten Lumajang)

Adanya usaha mikro kecil dan menengah merupakan peran penting dalam perekonomian nasional. Sebab selain membuka peluang usaha, UMKM juga dapat meminimalisir pengangguran. UMKM juga dapat menciptakan lapangan kerja baru yang dapat mendukung pendapatan rumah tangga. Salah satunya yang telah tumbuh dari dulu hingga saat ini adalah adanya pengusaha atau industri rumahan yang berupa pengolahan buah pisang yang diolah menjadi beberapa macam jenis olahan buah pisang yang berupa Kripik Pisang, Sale Pisang, Gethuk Pisang, Cake Pisang, dan Pisang Goreng. Untuk mengembangkan UMKM tersebut yakni dengan melibatkan pihak pemerintah untuk dapat memfasilitasi dan memberikan penyuluhan usaha agar bisa berkembang sehingga tidak hanya melibatkan seorang pengusaha UMKM tanpa campur tangan pemerintah. Dukungan tersebut diharapkan datang dari asosiasi pengusaha, dinas atau instansi terkait di lingkungan pemerintah Kabupaten dan Provinsi. Penelitian ini bermaksud untuk mengetahui variabel apa saja yang dapat mempengaruhi atau menambah laba para pengusaha UMKM Kripik Pisang yang ada di Kabupaten Lumajang, yang mana variabel yang dipilih antara lain: modal, kemitraan, pembinaan pemerintah, tenaga kerja dan area pemasaran produk. Dan hasil dari penelitian ini adalah: 1)Secara simultan variabel modal, kemitraan, pembinaan pemerintah, tenaga kerja dan area pemasaran produk memiliki pengaruh positif dan signifikan terhadap laba para pengusaha UMKM Kripik Pisang yang ada di Kabupaten Lumajang. 2)Secara parsial variabel modal, kemitraan, pembinaan pemerintah, tenaga kerja dan area pemasaran produk memiliki pengaruh positif dan signifikan terhadap laba para pengusaha UMKM Kripik Pisang yang ada di Kabupaten Lumajang. Kata Kunci: Modal, Kemitraan, Pembinaan Pemerintah, Tenaga Kerja, Area Pemasaran Produk
A Practical Overview of the Stool DNA Test for Colorectal Cancer Screening

The multitarget stool DNA test with fecal immunochemical test (sDNA-FIT) is recommended by all major US guidelines as an option for colorectal cancer screening. It is approved by the Food and Drug Administration for use in average-risk individuals aged 45 years and older. The sDNA-FIT tests for 11 biomarkers, including point mutations in KRAS, aberrant methylation in NDRG4 and BMP3, and human hemoglobin. Patients collect a stool sample at home, send it to the manufacturer's laboratory within 1 day, and the result is reported in approximately 2 weeks. Compared with FIT, sDNA-FIT has higher sensitivity but lower specificity for colorectal cancer, which translates to a higher false-positive rate. A unique feature of sDNA-FIT is the manufacturer's comprehensive patient navigation system, which operates 24 hours a day and provides active outreach for patient education and reminders in the first month after a test is ordered. Retesting is recommended every 1–3 years, although the optimal testing interval has not yet been determined empirically. The cost of sDNA-FIT is $681 without insurance, but Medicare and most private insurers cover it with no copay or deductible.
Risk of food and housing insecurity among college students during the COVID‐19 pandemic

Abstract The aim of this study was to assess college students’ food and housing insecurity risk amidst the pandemic. Data were collected through an online survey in the summer of 2020 from 1956 graduate and undergraduate students attending a large, private, urban university in the Midwest, U.S. Food insecurity among students increased (25% before; 29% during COVID) with housing insecurity staying roughly the same (34% before; 36% during COVID). Results indicate certain student groups were at greater risk of basic needs insecurity during the pandemic compared to their counterparts. Results also suggest changes in food and housing insecurity trends. College students are burdened with basic needs insecurity, exacerbated during the pandemic. Institutions need to work toward solutions to address the needs of vulnerable populations disproportionately affected by basic needs insecurity. Recommendations on addressing the basic needs of college students are also provided.
Teaching Workload and Performance: An Empirical Analysis on Some Selected Private Universities of Bangladesh

The study was conducted to endeavor the relationship between workload and performance for Bangladeshi university teachers. Workload has been assumed to be independent factor having three sub-categories: time spent in teaching, administrative activities and co-curricular responsibilities. Teaching performance was the dependent variable having three sub-categories: quality of teaching delivery, quality & quantity of research & training and implementation of new technology in teaching. 250 teachers from different categories of fifteen universities were chosen as participants through convenience sampling. Pearson’s correlation and regression analysis had been carried out to find the relationship between the variables. It was revealed that most independent variables are positively and strongly correlated with the dependent variables except time spent on teaching & implementation of new technology and administrative activities & implementation of new technology which are negatively correlated. The study indicates that to perform better, workload management should be appropriate and adjusted. The study willhopefully help the university management, academic researchers and trainers to formulate and implement an effective workload management system.
Increased risk of nonrelapse mortality post T‐cell‐replete haploidentical stem cell transplantation in patients with recurrence of acute graft‐versus‐host disease

Acute graft‐versus‐host disease (aGVHD) causes significant morbidity and mortality. While most studies focus on classic or late aGVHD, some patients with previous aGVHD achieve complete remission and later develop another episode of aGVHD. Data on recurrence of aGVHD (RaGVHD) are lacking. This study aimed to identify the incidence, risk factors, and impacts of RaGVHD after T‐cell‐replete haploidentical hematopoietic cell transplantation (haplo‐HCT) without posttransplantation cyclophosphamide. We evaluated patients with RaGVHD after haplo‐HCT between 2017 and 2019 and compared their outcomes to those of patients with no aGVHD and those of patients with one episode of de novo aGVHD. Of 199 patients included in the analysis, 45 experienced 50 cases of RaGVHD with a 1‐year cumulative incidence of 19.0% (95% CI: 14.5–24.6). Grade III–IV aGVHD was more common in RaGVHD than in previous aGVHD (22.2% vs. 4.4%, p = 0.01). Female donor to male recipient was strongly associated with RaGVHD (HR: 2.5, p = 0.009). The most common death in patients with RaGVHD was GVHD‐related, which was different from controls who mostly died from relapse (p = 0.008). RaGVHD was an independent risk factor for chronic GVHD (HR: 2.6, p = 0.006) and nonrelapse mortality (HR: 2.4, p = 0.019) and a significant predictor of lower GVHD relapse‐free survival (HR: 1.9, p = 0.020) and cGVHD relapse‐free survival (HR: 2.1, p = 0.007). In conclusion, clinical manifestations and negative impacts of RaGVHD needs to be recognized independently.
Timing of Spheno-Occipital Synchondrosis Closure in Cleft Lip and Palate Patients in Iranian Population

Objective This study aimed to evaluate the chronological age range associated with each stage of spheno-occipital synchondrosis (SOS) fusion in patients with cleft lip and palate compared to the noncleft group, using cone-beam computed tomography (CBCT) images. Design In this study, the degree of SOS fusion was assessed using a 4-stage scoring system on CBCT images of 190 individuals (92 patients with cleft lip and palate, 98 noncleft individuals). A χ2 test was performed to assess the correlation between age and fusion stage. The independent sample t tests were used to evaluate the differences in the mean values of the samples of each group and each sex, as well as the mean value of each stage (P < .05). Results The results showed that there was no significant difference in the timing of the SOS fusion stages between the patients with cleft palate and the noncleft group. Although the fusion process of SOS begins about one year earlier in females, the complete ossification occurs at the mean age of 18.5 for both sexes in the experimental group and the mean age of 19.0 in the noncleft group. Conclusions The present study found no differences in the fusion stages of the spheno-occipital synchondrosis between patients with cleft lip and palate and healthy individuals.
Physiotherapists’ perceptions of implementing evidence-based practice for patients with low back pain through the Enhanced Transtheoretical Model Intervention: a qualitative study

ABSTRACT Background Physiotherapists have been urged to implement evidence-based practice for the management of low back pain (LBP). However, recent evidence suggests that many fail to do so, specifically in accordance with eliciting and addressing psychosocial factors that impact pain. The Enhanced Transtheoretical Model Intervention (ETMI) for the Treatment of patients with LBP was developed in Israel according to the clinical guidelines and demonstrated clinically and cost-effectiveness. Objectives This study’s purpose is to explore physiotherapists’ perceptions of implementing evidence-based practice through the ETMI approach. Design Qualitative study. Methods Qualitative semi-structured interviews were conducted with 26 physiotherapists. The interviews were audio-recorded, transcribed, coded, and analyzed thematically to identify prevalent themes. Results Three main themes were identified from the transcripts, consisting of barriers and facilitators of implementing the intervention, and a meta-theme referring to shifts in the perceptions of professional role and identity. Conclusion The findings suggest that physiotherapists believed that implementing ETMI and adopting a psychosocial approach to LBP can be achieved by overcoming issues around communication skills, patient reassurance, and inter-professional collaboration. Therapists also highlighted the need for physiotherapy training to gain skills in combined physical and psychological approaches.
The influence of men on HPV vaccination of their spouse/partner in China

ABSTRACT Men involvement in HPV vaccine advocacy is important in a patriarchal society. This study aimed to investigate the influence of men on HPV vaccination of adult women. An online cross-sectional survey was undertaken between June and August 2019. Participants were fathers of children enrolled in schools in Fujian Province. A total of 1953 participants responded to our survey. Just over 60% reported they would definitely or likely support their spouse/partner to receive HPV vaccine. Physician recommendation (adjusted odds ratio [aOR] = 5.68, 95%CI = 3.89–6.86) and spouse/partner communication about HPV vaccination (aOR = 5.30, 95%CI = 3.72–7.55) were significant covariates associated with higher willingness to support women’s HPV vaccination. Perceiving HPV vaccination as only for women who have had multiple sex partners and HPV vaccination as a sensitive topic were significantly associated with lower willingness to support HPV vaccination. Over two-thirds (67.3%) reported joint HPV vaccination decision-making and 2.8% reported that it was entirely the man’s decision. The role of men in HPV vaccine acceptance and hesitancy among adult women is evident in China and warrants educational interventions to target men to enhance women’s HPV vaccination uptake.
Medical Encounters Among 94,033 Race Starters During a 16.1-km Running Event Over 3 Years in the Netherlands: SAFER XXVI

Background There are limited data on the medical encounters (MEs) occurring during mass community-based running events of shorter distances (10-21.1 km). The aim of this study was to determine the incidence and nature of MEs during the largest mass participation running event in the Netherlands. Hypothesis We hypothesize that the incidence and nature of MEs will be similar to other running events. Study Design Descriptive epidemiological study over 3 years of a 16.1-km (10-mile) running event. Level of Evidence: Level 4. Methods We investigated a total of 94,033 race starters at the 2017-2019 Dam tot Damloop (16.1 km), a point-to-point road race from Amsterdam to Zaandam, the Netherlands. All MEs were recorded by race medical staff on race day each year. MEs were retrospectively coded by severity, organ system, and final specific diagnosis (2019 consensus statement definition on mass community-based events). Incidence (I) per 1000 starters (95% CIs) were calculated for all MEs and serious/life-threatening MEs. Results: The overall incidence (per 1000 starters) of all MEs was 2.75 (95% CI, 2.44-3.11), the overall incidence of serious/life-threatening MEs was 1.20 (95% CI, 1.00-1.45; 44% of MEs). Heat illnesses accounted for most MEs: hypothermia I = 0.54 (95% CI, 0.41-0.71) and hyperthermia I = 0.46 (95% CI, 0.34-0.62). Central nervous system MEs were also common (dizziness/nausea, I = 0.79; 95% CI 0.63-0.99), followed by the cardiovascular system MEs (exercise-associated postural hypotension, I = 0.36; 95% CI, 0.26-0.51). Conclusion The overall incidence of MEs was low compared with longer-distance races (21.1-90 km), but the incidence and relative frequency of serious/life-threatening MEs (44% of all MEs) was much higher. Heat illness (hypothermia and exertional heat stroke) accounted for most serious/life-threatening MEs. Clinical Relevance: There is a need to implement prevention strategies and interventions by specialized medical practitioners in this and similar events.
A comparative study of hand-held magnetic susceptibility instruments

A study to compare six magnetic susceptibility (MS) instruments (the KT-10 sold by Terraplus Inc., RT-1 produced by Fugro, SM30 produced by ZH Instruments, MS2K & MS2C produced by Bartington Instruments and MPP-EMS2+ probe produced by GDD Instruments (denoted as GDD)) was conducted to characterize the equipment on the basis of their accuracies, resolution, range, reproducibility, ease of use and response to short term and medium term temporal drifts.
Characterization and outcomes of 414 patients with primary SS who developed hematological malignancies.

OBJECTIVE To characterize 414 patients with primary SS who developed hematological malignancies and to analyze how the main SS- and lymphoma-related features can modify the presentation patterns and outcomes. METHODS By January 2021, the Big Data Sjögren Project Consortium database included 11 966 patients fulfilling the 2002/2016 classification criteria. Hematological malignancies diagnosed according to the World Health Organization (WHO) classification were retrospectively identified. RESULTS There were 414 patients (355 women, mean age 57 years) with hematological malignancies (in 43, malignancy preceded at least one year the SS diagnosis). 376 (91%) patients had mature B cell malignancy, nearly half MALT lymphoma (n = 197), followed by DLBCL (n = 67), nodal MZL lymphoma (n = 29), CLL/SLL (n = 19) and follicular lymphoma (n = 17). Rates of complete response, relapses and death were 80%, 34% and 13%, respectively, with a 5-year survival rate of 86.5% after a mean follow-up of 8 years. There were significant differences in age at diagnosis (younger in MALT, older in CLL/SLL), predominant clinical presentation (glandular enlargement in MALT lymphoma, peripheral lymphadenopathy in nodal MZL and FL, constitutional symptoms in DLBCL, incidental diagnosis in CLL/SLL), therapeutic response (higher in MALT lymphoma, lower in DLBCL) and survival (better in MALT, nodal MZL and FL, worse in DLBCL). CONCLUSION In the largest reported study of hematological malignancies complicating primary SS, we confirm the overwhelming predominance of B cell lymphomas, especially MALT, with the salivary glands being the primary site of involvement. This highly-specific histopathological scenario is linked with the overall good prognosis with a 5-year survival rate of nearly 90%.
Logistic role of carnitine shuttle system on radiation-induced L-carnitine and acylcarnitines alteration

Abstract Purpose With the development of radiation metabolomics, a large number of radiation-related metabolic biomarkers have been identified and validated. The L-carnitine and acylcarnitines have the potential to be the new promising candidate indicators of radiation exposure. This review summarizes the effect of carnitine shuttle system on the profile of acylcarnitines and correlates the radiation effects on upstream regulators of carnitine shuttle system with the change characteristics of L-carnitine and acylcarnitines after irradiation across different animal models as well as a few humans. Conclusions Studies report that acylcarnitines were ubiquitously elevated after irradiation, especially the free L-carnitine and short-chain acylcarnitines (C2–C5). However, the molecular mechanism underlying acylcarnitine alterations after irradiation is not fully investigated, and further studies are needed to explore the biological effect and its mechanism. The activity of the carnitine shuttle system plays a key role in the alteration of L-carnitine and acylcarnitines, and the upstream regulators of the system are known to be affected by irradiation. These evidences indicate that that there is a logistic role of carnitine shuttle system on radiation-induced L-carnitine and acylcarnitines alteration.
Gerontological nursing in Ghana: Preferences and perceptions of nursing students

ABSTRACT Undergraduate nursing students in developed countries are reported to have poor perceptions and low preference for gerontological nursing. However, perceptions and preferences of undergraduate nursing students toward gerontological nursing in low-income countries have not been well explored. This study explored the perceptions and preferences of undergraduate nurses in Ghana toward gerontological nursing. A mixed method study design was used to explore Ghanaian undergraduate nursing students’ perceptions and preferences for caring for older people. One hundred and seventy-four nursing students were surveyed and 30 of them were interviewed. Quantitative data were analyzed descriptively using SPSS version 27. Content analysis was used to analyze qualitative data to generate themes. Response rate in the study was 73%. The majority of participants (95.4%) were below the age of 29. Gerontological nursing was ranked as the least preferred nursing specialty among graduating undergraduate nurses. Poor perceptions and inadequate knowledge about the care of older people were largely responsible for the lack of preference for gerontological nursing. Improving undergraduate nursing students’ knowledge about gerontological nursing is critical in correcting poor perceptions about gerontological nursing.
Subtle Cognitive Deficits Are Associated with Amyloid-β Positivity, but Not Severity of Self-Reported Decline: Results from the CoSCo Study

Introduction: Subjective cognitive decline (SCD) can be considered as the preclinical manifestation of Alzheimer’s disease (AD). The National Institute on Aging and the Alzheimer’s Association criteria for preclinical AD proposed that subtle cognitive changes appear along with AD biomarkers in the late stage of preclinical AD. The objective of this study was to explore whether subtle cognitive impairment (SCI) in individuals with SCD is associated with brain amyloid-β (Aβ) status and SCD severity. Methods: One hundred twenty individuals with SCD (mean age: 70.87 ± 6.10 years) were included in this study. SCI was defined as performance ≤ −1.0 SD on at least two neuropsychological tests. Participants underwent an amyloid positron emission tomography, which was assessed visually and quantitatively using standardized uptake value ratio (SUVR). The severity of SCD was assessed using two self-reported questionnaires: the SCD questionnaire based on the SCD-plus features and the Korean-Everyday Cognition (K-ECog) scale. Results: SCD individuals with SCI (n = 25) had more Aβ positivity than the SCD only group (n = 95) (44% vs. 15.79%; p = 0.002). In addition, the SCI group had a higher global SUVR than the SCD only group (p = 0.048). For self-reported questionnaires, there were no differences in SCD questionnaire total scores and K-ECog global and cognitive domain-specific scores between two groups. Conclusions: In SCD individuals, SCI was associated with higher Aβ positivity, but not with the severity of self-reported cognitive decline, compared to the SCD only group. These results suggest that the recognition of objectively defined subtle cognitive deficits may contribute to the early identification of AD in SCD.
Specificity in the Study of Mixed Emotions: A Theoretical Framework

Research on mixed emotions is yet to consider emotion-specificity, the idea that same-valenced emotions have distinctive characteristics and functions. We review two decades of research on mixed emotions, focusing on evidence for the occurrence of mixed emotions and the effects of mixed emotions on downstream outcomes. We then propose a novel theoretical framework of mixed-emotion-specificity with three foundational tenets: (a) Mixed emotions are distinguishable from single-valenced emotions and other mixed emotions based on their emotion-appraisal relationships; (b) Mixed emotions can further be characterized by four patterns that describe relationships between simultaneous appraisals or appraisals that are unique to mixed emotions; and (c) Carryover effects occur only on outcomes that are associated with the appraisal characteristics of mixed emotion. We outline how mixed-emotion-specific effects can be predicted based on the appraisal tendency framework. Temporal dynamics, the application of mixed-emotion-specificity to individual difference research, methodological issues, and future directions are also discussed.
Polyacrylamide hydrogel lubricates cartilage after biochemical degradation and mechanical injury

Intra‐articular injections of hyaluronic acid have been a mainstay of osteoarthritis treatment for decades. However, controversy surrounds the mechanism of action and efficacy of this therapy. As such, there has been recent interest in developing synthetic lubricants that lubricate cartilage. Recently, a synthetic 4 wt% polyacrylamide (pAAm) hydrogel was shown to effectively decrease lameness in horses. However, its mechanism of action and ability to lubricate cartilage is unknown. The goal of this study was to characterize the lubricating ability of this hydrogel and determine its efficacy for healthy and degraded cartilage. The study utilized previously established IL‐1β‐induced biochemical degradation and mechanical impact injury models to degrade cartilage. The lubricating ability of the hydrogel was then characterized using a custom‐built tribometer using a glass counterface and friction was evaluated using the Stribeck framework for articular cartilage. pAAm hydrogel was shown to significantly lower the friction coefficient of cartilage explants from both degradation models (30%–40% reduction in friction relative to controls). A striking finding from this study was the aggregation of the pAAm hydrogel at the articulating surface. The surface aggregation was observed in the histological sections of explants from all treatment groups after tribological evaluation. Using the Stribeck framework, the hydrogel was mapped to higher Sommerfeld numbers and was characterized as a viscous lubricant predominantly in the minimum friction mode. In summary, this study revealed that pAAm hydrogel lubricates native and degraded cartilage explants effectively and may have an affinity for the articulating surface of the cartilage.