Miracle-dz/UniFAR-FTUs huggingface dataset:
Biocuration of a Transcription Factors Network Involved in Submergence Tolerance during Seed Germination and Coleoptile Elongation in Rice (Oryza sativa)

Modeling biological processes and genetic-regulatory networks using in silico approaches provides a valuable framework for understanding how genes and associated allelic and genotypic differences result in specific traits. Submergence tolerance is a significant agronomic trait in rice; however, the gene–gene interactions linked with this polygenic trait remain largely unknown. In this study, we constructed a network of 57 transcription factors involved in seed germination and coleoptile elongation under submergence. The gene–gene interactions were based on the co-expression profiles of genes and the presence of transcription factor binding sites in the promoter region of target genes. We also incorporated published experimental evidence, wherever available, to support gene–gene, gene–protein, and protein–protein interactions. The co-expression data were obtained by re-analyzing publicly available transcriptome data from rice. Notably, this network includes OSH1, OSH15, OSH71, Sub1B, ERFs, WRKYs, NACs, ZFP36, TCPs, etc., which play key regulatory roles in seed germination, coleoptile elongation and submergence response, and mediate gravitropic signaling by regulating OsLAZY1 and/or IL2. The network of transcription factors was manually biocurated and submitted to the Plant Reactome Knowledgebase to make it publicly accessible. We expect this work will facilitate the re-analysis/re-use of OMICs data and aid genomics research to accelerate crop improvement.
Chaotic memristive circuit: equivalent circuit realization and dynamical analysis

In this paper, a practical equivalent circuit of an active flux-controlled memristor characterized by smooth piecewise-quadratic nonlinearity is designed and an experimental chaotic memristive circuit is implemented. The chaotic memristive circuit has an equilibrium set and its stability is dependent on the initial state of the memristor. The initial state-dependent and the circuit parameter-dependent dynamics of the chaotic memristive circuit are investigated via phase portraits, bifurcation diagrams and Lyapunov exponents. Both experimental and simulation results validate the proposed equivalent circuit realization of the active flux-controlled memristor.
A note on the recurrence of yellow fever epidemics in urban populations

An approximate expression is found for the probability density of the recurrence time between major outbreaks of a host-vector disease such as yellow fever, in which the infectious period of a host is short and the lifetime of a vector is short compared with that of a host. The typical interval between epidemics based on the modal value of this distribution is obtained. These results are the analogues of those obtained by Bartlett (1956), (1966) for the periodicity of measles epidemics in small communities.
Plasma confinement to enhance the momentum coupling coefficient in ablative laser micro-propulsion: a novel approach

We introduce for the first time the novel idea of manipulating the momentum coupling coefficient using plasma confinement and shock wave reflection from the cavity walls. The plasma was confined using cylindrical geometries of various cavity aspect ratios to manipulate the momentum coupling coefficient (Cm). The Nd: YAG laser (532 nm, 5 ns pulse duration) was focused on the ferrite sample surface to produce plasma in a region surrounded by cylindrical cavity walls. The multiple reflections of the shockwaves from the cavity walls confined the laser-induced plasma to the central region of the cavity that subsequently resulted in a significant enhancement of the momentum coupling coefficient values. The plasma shielding effect has also been observed for particular values of laser fluencies and cavity aspect ratios. Compared with the direct ablation, the confined ablation provides an effective way to obtain high Cm values.
Comparative Analysis on Clinical Characteristics Among Patients with Acute Hepatitis A Virus (HAV) and Patients with Acute Hepatitis E Virus (HEV): A Single-Center Retrospective Study from Bulgaria

Introduction The acute viral hepatitis was one of the most common conditions in daily clinical practice varying in different parts of the world. The aim of the present study was to perform a comparative analysis on clinical characteristics among patients with acute hepatitis A virus (HAV) infection and patients with acute hepatitis E virus (HEV) infection admitted to the Military Medical Academy (MMA), Sofia, Bulgaria. Methods A retrospective study was performed at MMA, between 1 January 2016 and 31 December 2021. The etiological diagnosis was confirmed by enzyme-linked immunosorbent assay (ELISA) HAV/HEV IgM serology assays. Results The current survey included 231 patients with mean age 45.11 ± 16.08 years (95% confidence interval: 43.04–47.19). According to the case definition, inclusion and exclusion criteria, persons were divided into two groups: patients with acute HAV infection (68.4%; 158/231) and patients with acute HEV infection (31.6%; 73/231). Males with HEV had 3.091 times the odds of comorbidity “hypertension” than males with HAV (p = 0.032). There were almost equal odds of increased ALT (odds ratio = 0.999; p = 0.003) in men with HEV and men with HAV. Females with HEV had 5.161 times the odds of comorbidity “hypertension” compared with females with HAV (p = 0.049). We found almost equal odds for elevated ALT in women with HEV and women with HAV (OR = 0.999; p = 0.025). In the non-elderly group (<60-year-old), HEV individuals had 4.544 and 10.560 times the odds of comorbidities “hypertension” and “cardiovascular diseases” compared with HAV patients (p < 0.05). We found almost equal odds for elevated ALT in HEV patients and HAV participants (OR = 0.998; p = 0.002). Conclusion The results from the current study may support the physicians daily care for patients with acute HAV and acute HEV.
Clinical Value of Combined Multi-Indicator Tests in Diagnosis of Benign Ovarian

Background To investigate the existence and degree of correlation between benign ovarian tumors and physiological indicators such as reproductive hormones and tumor markers. Methods A total of 150 patients with benign ovarian tumors admitted to Jiaxing First Hospital between January 1, 2019, and May 30, 2021, were enrolled as research subjects, while 104 healthy women were enrolled in the control group. Comparative analysis of the correlation between the reproductive hormones LH, FSH, T, E2, and the tumor indicators AMH, AFP, CEA, CA125, and CA199 between the groups was performed. Results There was no statistical difference in LH, FSH, T, AMH, and CEA expression levels between the experimental and control groups (p≥0.05); E2, CA125, and CA199 levels were higher significantly in the experimental group than in the control group (P<0.001); AFP levels were significantly lower in the experimental group than in the control group (P<0.05). CA125 (0.762) had the highest AUC when diagnosing the value of each index of E2, CA125, and CA199 for benign ovarian tumors. CA125 had the highest sensitivity (56.7%), followed by E2 (50.0%); CA199 had the highest specificity (84.5%), followed by CA125 (83.7%). The combined diagnosis of benign ovarian tumors was performed using different combinations of the indicators. When the two indicators were combined for diagnosis, the combination of E2 + CA199 had the highest sensitivity (82.6%), whereas the combination of CA125 + CA199 had the largest AUC (0.783) and the highest specificity (86.4%). The combined diagnosis of E2+CA125+CA199 had a higher AUC than the combined diagnosis of the two indicators (0.805), with a sensitivity of 77.2%, and a specificity of 70.9%. Conclusion The most relevant factors for benign ovarian tumors are E2, CA125, and CA199 and the combination of these three indicators has the highest AUC for disease prediction while increasing the detection rate of benign ovarian tumors.
The Effect of Advertising on Repatronage Intention with Brand Awareness and Brand Image as Intervening Variable

The purpose of this study was to examine the effect of advertisement on repatronage intention with brand awareness and brand image as an intervening variable at UD. Pari Kuning Banyuwangi. Data was taken using a google form on a sample of 120 respondents using purposive sampling, from the population in the form of consumers who had seen advertisements and visited Pari Kuning agro-business and bistro. Based on the result of path analysis and hypothesis testing, it showed that advertisement, brand awareness, and brand image had a positive and significant effect on repatronage intention. Advertisements had a positive and significant effect on brand awareness and brand image. Brand awareness and brand image can mediate the effect of advertisement on repatronage intention.
A physical resist shrinkage model for full-chip lithography simulations

Strong resist shrinkage effects have been widely observed in resist profiles after negative tone development (NTD) and therefore must be taken into account in computational lithography applications. However, existing lithography simulation tools, especially those designed for full-chip applications, lack resist shrinkage modeling capabilities because they are not needed until only recently when NTD processes begin to replace the conventional positive tone development (PTD) processes where resist shrinkage effects are negligible. In this work we describe the development of a physical resist shrinkage (PRS) model for full-chip lithography simulations and present its accuracy evaluation against experimental data.
Gaseous Pollutants and Particulate Matter in Ambient Air: First Field Experiment in an Urban Mediterranean Area (Nador, Morocco)

Mediterranean urban areas are reportedly affected by poor air quality due to numerous emission sources, as well as topography and meteorological conditions that facilitate the accumulation of pollution. This present study makes an initial attempt to assess the effect of gaseous pollutants (NO 2 , CO, and O 3 ) and particulate matter (PM 2.5 and PM 10 ) on the air quality of Nador city, which lies on the Mediterranean coast of Morocco. Three daily, short-term sampling campaigns were conducted between 2016 and 2018 in an urban area. The concentrations of PM 2.5 and PM 10 together with elemental compositions (up to 16 elements) and black carbon content were determined. The obtained data were characterized using descriptive analysis, correlation matrices, elemental enrichment factors (EFs), and elemental ratios. On average, the particulate matter and gaseous pollutant concentrations were below the national standard limits. Two categories of PM 2.5 and PM 10 sources, as derived from the EF investigation, were defined as soil/crustal (Ti, Al, Mn, Sr, K, Na, Ba, and V) and anthropogenic (Ni, Cr, Cu, Zn, and Pb). For black carbon, biomass burning was found to be the largest contributing source (3.1–8.4 µ g m –3 ), more so than fossil fuels (0.9–1.8 µ g m –3 ). This study highlights that an air quality management plan should be established for Nador city, including the implementation of a network of monitoring stations to help with identifying and controlling the activities causing air pollution.
Evaluation of interprofessional education for shared decision making in drug therapy: a scoping review on methods and instruments

Abstract This study aimed to describe the research methods and instruments used in the evaluation of interprofessional education strategies for shared decision making in drug therapy. The types of evaluation employed were categorized according to Kirkpatrick’s adapted model. A scoping review was conducted, following the PRISMA-ScR recommendations. Among the 21 selected studies, there was a predominance of quantitative methods in the evaluation of educational experiences (n=18). Of these, the most common aspect evaluated was “students’ attitudes and perceptions towards interprofessional education and practice” by means of validated instruments (n=13). Ten different instruments were identified and found to be in line with the Interprofessional Education Collaborative competencies. The variety of instruments signals the growing production of knowledge about this topic, but points to the challenge of conducting comparative analyses between educational experiences around the world.
Sex Differences in 90-Day Functional Outcomes for Acute Ischemic Stroke Patients With Obstructive Sleep Apnea

Background Obstructive sleep apnea (OSA) is characterized by repeated episodes of either full or partial obstruction of the upper airway. OSA is an independent risk factor for acute ischemic stroke (AIS) and a contributor to other key risk factors. OSA may damage endothelial and brain tissues and worsen outcomes following AIS. We aimed to evaluate the impact of sex differences on 90-day functional outcomes following AIS in an OSA population, as measured by the modified Rankin Scale (mRS) score. Methodology We performed a retrospective study of patients with OSA and AIS from the Houston Methodist Hospital Outcomes-Based Prospective Endpoints in Stroke (HOPES) Registry from 2016 to 2022. Patients with charts that noted a diagnosis of OSA before AIS or within the 90 days following AIS were included. A multivariable logistic regression model was constructed adjusting for demographics, first admit National Institutes of Health Stroke Scale (NIHSS), and comorbidities on the binary outcome. The odds ratios (ORs) and 95% confidence intervals (CIs) were reported, providing likelihood estimates of a shift to higher mRS for a given comparison between females (reference category) and males. Statistical significance was defined as two-tailed p-values <0.05 for all tests. Results From the HOPES registry, 291 females and 449 males were found to have OSA. Males had a higher proportion of comorbid conditions such as atrial fibrillation (15% vs. 9%, p = 0.014) and intracranial hemorrhage compared to females (6% vs. 2%, p = 0.020). The multivariate logistic regression model showed that males were at two times higher risk for developing poor functional outcomes at 90 days (OR = 2.35, 95% CI = 1.06-5.19), p < 0.001). Conclusions Males were found to have two times higher risk for developing poor functional outcomes at 90 days. This may be due to more severe oxygen desaturation, increased susceptibility to oxidative stress, and greater frequency of full airway obstruction in males. Greater emphasis on early diagnosis and treatment of OSA may be necessary to reduce the disproportionate incidence of poor functional outcomes, particularly among apneic male stroke survivors.
On The Equivalence Of Representations Of Finite Groups By Groups Of Automorphisms Of Modules Over Dedekind Rings

Let t be a Dedekind ring whose quotient field we denote by K. If is a prime ideal of t, let o denote the ring of all -regular elements of K. If is a torsion free i-module, let K denote the smallest K-module into which can be embedded and let o denote the o-submodule of K generated by .
Non-quasi-static eigenstates of Maxwell's equations in a two-constituent composite medium and their application to a calculation of the local electric field of an oscillating dipole

In conventional optics the image is formed only by the propagating waves and the information encoded in the evanescent waves is lost, leading to limited resolution. A negative refractive index slab can amplify evanescent waves and enable the generation of an image by both propagating and non propagating waves, theoretically leading to unlimited resolution. Here we analyze the imaging of an oscillating dipole in a composite structure composed of an (epsilon)1 slab surrounded by an (epsilon)2 medium, where μ = 1 everywhere. For this purpose we calculate all the eigenstates and eigenvalues of the full Maxwell equations for the composite structure and develop an exact expansion for the local electric field E(r) in the system. Then we calculate the intensity and resolution for various permittivity values. We show that only the low order modes contribute to the expansion of the electric field which enables an efficient calculation of the physical quantities.
Congenital syphilis: associated factors in a follow-up outpatient clinic

Abstract Objective: This study aimed to describe the characteristics of mothers and children assisted in a follow-up clinic for congenital syphilis and identify the factors associated with the confirmation of the diagnosis. Methods: This is a prospective study conducted from 2016 to 2019 in Montes Claros, Northern Minas Gerais, Brazil. Specific forms addressing maternal sociodemographic, behavioral, and lifestyle habit characteristics, as well as characteristics related to access to healthcare, were used. Hierarchical Poisson regression analysis was performed to define the factors associated with diagnostic confirmation, including the calculation of the prevalence ratios (PR) and respective 95% confidence intervals (95%CI). Results: A total of 200 binomials (mother-child) who attended at least one appointment as part of the follow-up after discharge from the maternity hospital were eligible for the study. The mothers were mostly young (79.0%), with a low educational level (43.0%), and black (89.5%). Nearly half of the mothers reported not having a steady sexual partner (42.5%). About a quarter attended less than six prenatal appointments (27.5%). Nearly half did not treat the disease adequately during pregnancy (24.5%). The diagnosis of congenital syphilis was confirmed for 116 children. The following factors were associated with the diagnostic confirmation after multiple analyses: low maternal educational level (PR 1.30; 95%CI 1.05–1.60), maternal risky sexual behavior (PR 1.34; 95%CI 1.07–1.66), inadequate treatment of the mother (PR 3.16; 95%CI 2.42–4.47), and lack of treatment of the partner (PR 1.44; 95%CI 1,18–1.81). Conclusions: Syphilis remains a major challenge. The results highlight the social inequities associated with congenital syphilis and the lack of proper management of pregnant women and their partners.
Designing and determining the effectiveness of a suicide intervention package for psychologists working in the primary health care system

Aims: Suicide is a major public health problem around the world. The present study aimed to design and determine the effectiveness of a suicide intervention package for psychologists working in the primary health care system in Hormozgan Province. Materials and Methods: This study was conducted in two phases: qualitative and quantitative phases. In the qualitative phase, it was a thematic analysis type, and in the quantitative phase, it was quasi-experimental type with pretest–posttest in two groups of intervention and comparison. To standardize the suicide intervention package, Delphi method was used, and for quantitative content validity, content validity index (CVI) and content validity ratio (CVR) were used. In the quantitative phase of the study, the statistical population of the study included 270 people who had suicidal ideations and had no history of suicide attempt. Among them, 135 people were included in the intervention group and 135 people were included in the comparison group using a convenience sampling method. They were selected among those referred to eight comprehensive rural and urban health service centers in eight cities of Hormozgan Province. The results were analyzed by MANCOVA statistical test. Results: CVR was more than 0.75 and CVI was more than 0.87. In the quantitative phase, the results showed a significant difference between the means before and after the intervention for the variables of psychological distress, suicidal ideation, and hopelessness (P < 0.01). Conclusion: It seems that psychological suicide preventive interventions in the primary health care system are effective in reducing psychological distress,suicidal thoughts and hopelessness.
SAMPLE MEANS, SAMPLE AUTOCOVARIANCES, AND LINEAR REGRESSION OF STATIONARY MULTIVARIATE LONG MEMORY PROCESSES

We develop an asymptotic theory for the first two sample moments of a stationary multivariate long memory process under fairly general conditions. In this theory the convergence rates and the limits (the fractional Brownian motion, the Rosenblatt process, etc.) all depend intrinsically on the degree of long memory in the process. The theory of the sample moments is then applied to the multiple linear regression model. An interesting finding is that, even though all the regressors and the disturbance are stationary and ergodic, the joint long memory in one single regressor and in the disturbance can invalidate the usual asymptotic theory for the ordinary least squares (OLS) estimation. Specifically, the convergence rates of the OLS estimators become slower, the limits are not normal, and the standard t- and F-tests all collapse.
The effect of pharmacological treatment in combination with vitamin K on healing in an experimental rat model of osteoporosis

Objectives This study aims to compare the effects of teriparatide, zoledronic acid, and their combination therapy with vitamin K on osteoporotic rats. Materials and methods We divided a total of 50 female Sprague-Dawley rats into five groups: A (the control group), B and D (the teriparatide group), and C and E (the zoledronic acid group). Following ovariectomy and subcutaneous heparin administration at a dose of 2 IU/kg for four weeks, osteoporosis was created. Groups A, B, and C were fed with standard feed, while Groups D and E were fed with vitamin K-rich feed. After four weeks of treatment, sacrification was performed. The right and left femurs were separated for histopathological and biomechanical evaluation, respectively. For histopathological evaluation, the femurs were decalcified, and the sections were stained with hematoxylin-eosin and evaluated under a light microscope. Fracture healing was evaluated using the classification system as described previously. For biomechanical evaluation, the 3-point stress test and torsion stress test were applied to 10 femurs from each group. Results Groups B-E were histopathologically and biomechanically superior to Group A in fracture healing of osteoporotic rats; however, it was not statistically significant (p>0.05). The group that received additional vitamin K was histopathologically and biomechanically superior to the group which was fed with standard feed, although it was not statistically significant (p>0.05). Conclusion Our study results indicated that both teriparatide and zoledronic acid had beneficial effects on osteoporotic fractures with comparable histological and biochemical results. Vitamin K promoted teriparatide and zoledronic acid treatment on osteoporotic fracture healing. Based on these findings, combination therapies may yield the most optimal results in biomechanical and histological examinations.