Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of amyloid-beta and tau in tear fluid of patients with Alzheimer’s disease

Background There is growing interest in finding non-invasive alternatives to cerebrospinal fluid (CSF) that could serve as front-line diagnostics for Alzheimer’s disease (AD). In this study, we investigated AD-specific biomarkers in tear fluid.Methods Tear fluid was collected from 25 patients with subjective cognitive decline SCD), 24 patients with mild cognitive impairment (MCI), 11 dementia patients and nine controls. Amyloid-beta peptides (AB38, AB40, AB42), t-tau and p-tau levels in tear fluid were determined using multiplex immunoassays.Results Tear t-tau levels in dementia, MCI and SCD patients were higher than in HC (p = 0.002, p = 0.002 and p = 0.013, respectively). A negative correlation between AB42 and t-tau was found in both tear fluid and CSF. Levels of tear p-tau were detectable in patients but not in HC.Conclusions This study shows for the first time presence of amyloid-beta peptides (AB38, AB40, AB42), t-tau and p-tau in tear fluid.
Social Networking Sites for e-Recruitment: A Perspective of Malaysian Employers

The use of social networking sites (SNS) for e-recruitment has shifted the focus away from traditional hiring and selection processes. They are commonly used in the search and acquisition of new employees and are projected to expand in the near future as an e-recruitment tool. However, there is a lack of material on SNS and their impact on an employers’ intention to use these sites for e-recruitment, in the context of Malaysia. Hence, there is an acute necessity for research on the extent that the features of SNS can influence the employers’ intention to use SNS for e-recruitment and to know how to keep utilizing the platform for future e-recruitment. This study aims to identify the key features of SNS that lead to employers’ intention to use SNS for e-recruitment in Malaysia. In this cross-sectional study, random sampling was utilized to obtain data from 198 recruitment professionals using online survey. The findings show that data quality, reliability, networking spectrum and simplicity of navigation of SNS are the key predicting factors for intention to use SNS for e-recruitment. Therefore, employers should acknowledge these key features of SNS to achieve their e-recruitment goals.
Investigation of the antioxidant defensive role of both AD-MSCs and BM-MSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’ tissues

Diabetes mellitus (DM) could negatively affect patients’ health via inducing a lot of serious functional hazards in many tissues’ cells at molecular levels. Recently, many scientists had proposed stem cell therapy being an appropriate alternative treatment protocol for numerous health threatening issues including diabetes. Therefore, the current study was designed to investigate the antioxidant potentiality of two MSCs types in alleviating tissues’ oxidative stress dramatic elevation resulting as a consequence of Type 1 DM induction. In our 4 weeks study, animals were divided into four groups: control group, STZ-diabetic group (D), D+AD-MSCs group and D+BM-MSCs group. Data reported that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited a marvelous body tissues (Pancreas, Liver and Kidney) enhancing capabilities in attenuating the oxidative stress status; as evidenced by XO, ROS, and MDA levels down-regulation; with a general concomitant elevation in the antioxidants’ content; evidenced by many enzymatic and non-enzymatic antioxidants up-regulation; relative to the diabetic untreated group. Interestingly, comparing both treatments with each other and to control group, most of the measured parameters were reverted back to near normal levels after AD-MSCs injection; which clearly point out their stunning health benefits and superiority as anti-diabetic agent in overcoming different tissues’ complications; owing to their marked cytoprotective and regenerative potentialities. Abbreviations AD-MSCs: adipose-derived mesenchymal stem cells AGEs: advanced glycation end products BM-MSCs: bone marrow-derived mesenchymal stem cells CAT: catalase CD: cluster of differentiation D: diabetic DM: diabetes mellitus DMEM: dulbecco’s modified Eagle’s medium FBG: fasting blood glucose FBS: fetal bovine serum GPx: glutathione peroxidase GRd: glutathione reductase GSH: glutathione GST: glutathione-S-transferase H2O2: hydrogen peroxide HO-1: heme-oxygenase 1 iNOS: inducible nitric oxide synthase IPCs: insulin producing cells ISCT: international Society for Cellular Therapy LPO: lipid peroxidation MDA: malondialdehyde MSCs: mesenchymal stem cells NO: nitric oxide PBS: phosphate-buffered saline *Address correspondence to: Shady G. El-Sawah, dr.shadygamal83@gmail.com Received: 04 April 2021; Accepted: 14 May 2021 BIOCELL ech T Press Science 2021 45(6): 1561-1568 Doi: 10.32604/biocell.2021. 016869 www.techscience. com/journal/biocell This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PUFA: poly-unsaturated fatty acids ROS: reactive oxygen species SEM: standard error of mean SOD: superoxide dismutase SPSS: statistical Package for Social Scientists STZ: streptozotocin T1DM: type 1 diabetes mellitus TAC: total antioxidant capacity TBARS: thiobarbituric acid reactive substances TOS: total oxidative status XO: xanthine oxidase
The Influence of Social Network Use on Students' Academic Performance

Social Network Sites (SNSs) are widely used by university students these days. The underlying reasons behind this use vary between academic and nonacademic purposes. The question is whether this use influences the students' academic performance or not. The aim of this study is to answer this question by examining the impact of five potential variables on the use of SNS, and the influence of this usage on the students' academic performance at Palestine Technical University- Kadoorie (PTUK). Five variables are included: the gender, age, faculty, duration of use, and computer self-efficacy. Stratified sampling technique was used to gather the required data, 369 valid survey items were retrieved and analyzed using SPSS 20.0. The findings revealed that among the five variables, only students' faculty and computer self-efficacy have positive influence on SNS use, and SNS use has positive influence on students' academic performance. The researchers recommend that PTUK should adopt strategies that direct students' use of SNS in beneficial ways
Serum cortisol and serum testosterone levels in idiopathic central serous chorioretinopathy

Aim: To analyse the serum cortisol and serum testosterone levels in idiopathic central serous chorioretinopathy. Material and methods: The prospective interventional study was conducted in the central laboratory associated with the Department of Ophthalmology, Subharti Medical College, Meerut. A study was conducted in 30 cases of CSR. The patients were divided into two groups i.e. Group A (15 patients with unilateral sudden painless loss of vision of less than one month of duration serving as cases and Group B (15 patients with no signs and symptoms serving as control). Evaluation of Macular thickness was done using OPTOVUE RTvue 100 OCT procedure. After pupil dilation, the patient is seated at the machine, asked to fixate at the internal fixation point and scan is obtained. The macular thickness map was taken to measure the thickness of macula. Fundus Fluorescein Angiography (FFA) was done, if required. Patients of both the groups underwent investigations such as dilated fundus examination, serum cortisol and serum testosterone levels. Results: Mean serum cortisol (μg/dL) among the case group was higher as compared to the control group with statistically significant difference as p
Stress, anxiety, and depression in social work students from Peru.

OBJECTIVE To report the magnitude of symptoms of stress, anxiety, and depression in Social Work Students (SWS) from Peru and the stressors associated with each illness. Moreover, to validate the DASS-21 tool (Spanish version) with a Peruvian SWS sample. METHOD Quantitative study that applied the DASS-21 scale to a sample of 152 Peruvian SWS. Sociodemographic data and college stressors over stress, anxiety, and depression were modelled with factorial analysis, multiple regressions, ANOVA, and t-tests. Descriptive statistics were also used. The research started in August 2018 and end in February 2019. RESULTS The study concludes that 48% of Peruvian SWS suffer from severe or extremely severe symptoms of stress, anxiety, or depression. Female students are the most affected by these illnesses. The DASS-21 Spanish version was validated in a new sample of Peruvian SWS. The profile of the SWS from Peru is reported. CONCLUSION Peruvian SWS are suffering symptoms of stress, anxiety, and depression at different levels. There are college stressors that increase the symptoms of stress, anxiety, and depression in these students.
Cerebral Malaria Associated with Acute Renal Failure in a Sudanese Patient: Case Report

Malaria is a common health problem especially in the tropics. Cerebral malaria is a worse complication of the disease with unknown pathophysiology. In this scenario, a Sudanese housewife was brought to the emergency room after a sudden fall in the ground, she was in coma. Investigations revealed sever falciparum malaria, thrombocytopenia and features of acute renal injury. Quinine was prescribed in addition to antithrombotic, diuretics and supportive medications. In the following day she developed aspiration pneumonia and a fourth generation antibiotic was prescribed. One day later she looked very ill, jaundiced with features of Disseminated Intravascular Coagulation (DIC). Her general condition was not improving, and then she was arrested and died. Multiple organs failure associated with sever malaria was considered as the cause of death.
The Effect of Water Filtration on Cholera Mortality

There is debate among researchers regarding the importance of water filtration in reducing mortality during the epidemiological transition. However, there is limited research on how water filtration affected cholera mortality during the second half of the 19th century. Using historical micro-data, this paper provides new evidence on the importance of water filtration in reducing cholera mortality during an outbreak. The results show that access to filtered water protected almost completely against cholera mortality. Water filtration could thereby have contributed more to mortality decline than what has previously been documented.
Prenatal Cocaine Increases Dendritic Spine Density in Cortical and Subcortical Brain Regions of the Rat

Alterations in dendritic spine density following prenatal cocaine exposure were examined in the present study. Timed pregnant rats were injected daily with 30 mg/kg cocaine or saline during gestation. At postnatal day 21, male and female animals were separated and spine density was assessed following Golgi impregnation. In prenatal cocaine-exposed rats, significant increases in dendritic spine density were observed on pyramidal cells in the CA1 region of the hippocampus, basal dendrites of layer II/III of the medial prefrontal cortex, medium spiny neurons of the striatum and the core of the nucleus accumbens, as well as in neurons of the ventromedial hypothalamic nucleus. No differences were observed in either apical or basal dendrites of pyramidal cells in layer III of the sensory cortex or layer V of the medial prefrontal cortex, or in apical dendrites of layer II/III pyramidal cells of the medial prefrontal cortex. Moreover, there were no sex differences in any region examined. These results demonstrate that prenatal cocaine exposure increases spine density in many brain regions at postnatal day 21, and this effect is independent of sex.
Knowledge and Attitude towards Sexual and Reproductive Health Rights and Associated Factors among High School Students in Machakel District,Northwest Ethiopia

Background: Young people have the right to make choices regarding their own sexuality, as far as they respect the rights of others. To do this, the knowledge of those rights and positive attitude in exercising these rights is critical to youth’s ability to protect them from unwanted reproductive outcomes. However, many young people do not have the information or means to protect themselves from these problems. Therefore, this study aimed to assess knowledge and attitude towards Sexual and Reproductive Health (SRH) rights and associated factors among high school students in Machakel District. Methods: School based cross sectional study was employed among 421 high school adolescents in Machakel District from March16-20/2019. Stratified sampling technique was used to select study participants. Data was collected through structured self-administered questionnaires. Data processing was done using Epi Data version 3.1then transferred to SPSS version 20 software. Bivariate & multivariate logistic regression was done to assess the association of factors with student’s knowledge and attitude towards SRH rights by calculating odds ratios, their 95% confidence limits and P-value less than 5% were taken as statistically significant. Results: Overall, more than half (55.9%) of students were found to be knowledgeable and 46% had favorable attitude towards SRH rights. Knowledge among high school students was significantly associated with being female (AOR=0.52, 95% CI= 0.33, 0.81), urban resident (AOR=3.43,95%CI=1.99, 5.93), being in grade ten (AOR=1.67,95%CI=1.08,2.58), participation in RH clubs (AOR=2.18, 95%CI=1.37, 3.47), discussion of SRH issues with parents (AOR=2.62, 95%CI=1.58, 4.33) and with friends (AOR=1.77, 95%CI=1.15, 2.74) while getting information on SRH(TV/Radio) (AOR=1.61, 95%CI=1.02, 2.54) and had access to reproductive health services (AOR=3.00, 95%CI=1.30, 6.90) were significantly associated factors with favorable attitude towards SRH rights. Conclusions: The level of student’s knowledge and attitude towards SRH rights were found to be low. Being female, urban resident, being in grade ten, participation in RH clubs, and discussion of SRH issues with parents and friends had significant association with knowledge while getting information on reproductive health and had access to reproductive health services with favorable attitude towards SRH rights. Hence, encouraging discussions with parents and participation in RH clubs may improve the knowledge and attitude of students on SRH rights.
Are There Gender Differences in Sustainable Entrepreneurship Indicators Amongst SMEs in South Africa? Application of MANOVA

In addition to the contributions and relevance of entrepreneurship activities to economic growth and development of countries, various factors have equally been advanced as responsible for the success stories of entrepreneurship sustainability worldwide. However, the influence of success factors on gender ownership of entrepreneurship activities is a relatively new aspect in the field of research that has not gained much academic attention in the literature especially in South Africa. This debate is so important in the face of the various agitations for equal participation of women and the inconclusive debate that women are better managers of business enterprises. In this article, using the Multivariate Analysis of Variance (MANOVA) technique, we examined the extent to which sustainable entrepreneurship indicators (finance, social and environmental) account for any disparity in gender ownership and management of business enterprises in South Africa. A stratified sampling method was adopted for the survey. Our analytical technique (MANOVA) created a new summary dependent variable, which is a linear combination of each of our original dependent variables. Confidence intervals of 95% and margins of error (3%) were used to validate the results. Findings indicate that the only difference that exists as per gender ownership disparity is around financial resources. There is therefore a need to realign programmes and policies to reduce this gendered inequality.
COMPARISON BETWEEN THE TERMS CONSTRUCTABILITY AND BUILDABILITY: A SYSTEMATIC LITERATURE REVIEW

Buildability deals with the optimal integration of construction expertise at various project stages to achieve the overall project goals. Incorporation of buildability improves the construction project performance in terms of its cost, quality, productivity, safety, and results early completion. Thus, having a sound understanding of buildability concept is paramount for finding solutions for transforming current practices towards successful project deliveries. The numerous past studies reviewing the concept of buildability in the past have highlighted the interchangeability of the terms “constructability” and “buildability”. However, in some studies, these two terms contradict rather than considered similar. Moreover, the application of the concept of buildability is widely discussed during the design phase while some studies recommend it to be applied in the construction phase. Thus, there is no clear consensus on the clarity of the key constructs of these terms or when to apply buildability. This paper aims to systematically review the application of the concepts “buildability” and “constructability” in the construction sector and compare the definitions to understand the key constructs and best phase of the construction project for its applicability. A structured literature review covering indexed publications from 2011-2021 was carried out to identify the existing literature. Following a Systematic Literature Review (SLR) technique, a total of 38 out of 162 research contributions have been considered for an in-depth analysis. The choice of interpretations, comments, statements, perspectives, and definitions used in 38 studies were examined. The study identified the key constructs of two terms and recommends applying buildability throughout the lifecycle of the project.
Assesment of non-timber Brahma Kamal (Saussurea obvallata (DC.) Edgew.), an important Himalayan medicinal plant: Ethnomedicinal, phytochemical and pharmacological overview

Background: The genus Saussurea of Asteraceae comprises approximately 490 species. Plants belonging to this genus are being used in different countries as traditional medicines. Brahma Kamal ( Saussurea obvallata (DC.) Edgew. ), is one of the most important and endangered species of this genus and is being used in traditional, ornamental and religious purposes. The aim of this work is to review and understand the scientific work conducted so far on S. obvallata, which includes its ethnomedicinal uses, pharmacognostic description, phytochemistry, pharmacology, micro-propagation and important conservation aspect. Methods: Systematic literature searches were performed on S. obvallata through various scientific search engines including Agricola, ACS publications, Google patents, Google Scholar, J-STAGE, JSTOR, PubMed, Science Direct, Scopus, SpringerLink, Taylor & Francis, Web of Science, USPTO, Wiley, published books and conference proceedings using keywords “Saussurea Kamal” and “Brahma' lotus” for screening of relevant information. Results & Conclusion : The literature analysis revealed diverse traditional uses of S. obvallata , against wounds, paralysis, cerebral-ischemia, cardiac and mental disorders. Various extracts (methanol, ethanol, petroleum ether, chloroform, n-butanol, aqueous, etc.) of S. obvallata were evaluated for their phytochemicals and pharmacological activities. Additionally, anti-hypoxia, anticancer, radio-protective, antioxidant and antimicrobial activities were also studied using different in-vitro and in-vivo models. S. obvallata is being used widely in traditional medicine and socio-economic applications but scientifically, it is not fully assessed regarding its complete therapeutic effects, toxicity and safety in human body. Further studies are essential and should focus on conservation, cultivation and sustainable utilization of the species.
Audience Diversity and Wellbeing at UK Drag Events

Over the last 15 years, there has been a significant increase in the promotion and integration of drag culture into mainstream society. Drag events have the ability to create a safe place for people from diverse backgrounds to celebrate and gather. What were once underground expressions of gender and political protest for the LGBTQ+ (lesbian, gay, bisexual, transgender, queer plus other identities) community, drag events have now transcended into a modern-day phenomenon, bringing people together to participate and feel a sense of enjoyment and wellbeing. The current literature on drag culture focuses on the performers’ perspective rather than the audience’s. This study aims to explore the diverse nature of attendees at UK drag events and to demonstrate how these events create a sense of inclusivity and impact the wellbeing of those attending. An online qualitative survey of respondents (n=248) who had attended at least one drag event in the UK was carried out. This was a UK study which encompassed experiences from across the country. This focus on the UK is justified due to the dearth of literature in this geographical area.The results indicate that drag events in the UK have become more mainstream, with the audience demographic becoming more diverse and inclusive. Drag events were considered by the attendees as a safe space, where they seek escapism from everyday life by immersing themselves in the drag experience. This enhanced their mental and emotional wellbeing. The study demonstrated that drag events provide an exciting, stimulating, and novel experience where individuals have a place for self-expression, can socialise, have fun, be accepted and feel a sense of freedom and happiness in a non-judgmental environment.
Shaping the teaching and learning of intercultural communication through virtual mobility

The globally mobile reality of today’s world has made the field of intercultural communication increasingly relevant as people more often find themselves in intercultural situations. As a result, language teachers must be more prepared to work in intercultural contexts, and to teach their own students how to communicate across differences in intercultural situations both physically and virtually. The present paper examines this special issue’s topic of physical and virtual mobility and intercultural competence through the lens of teacher education. Using narrative inquiry, two teacher educators in very different geographic and socio-economic contexts (US and Colombia) explore their own attempts at developing intercultural communication in teacher learners through a WhatsApp pen pal exchange project in their intercultural communication classes before and during the COVID-19 pandemic. Findings reveal different ways in which virtual mobility and other affordances of WhatsApp can be harnessed to achieve various aims of intercultural education, but also how activities such as the pen pal exchange can be improved in order to align more with current theories of intercultural communication.
Teacher's Emotional Exhaustion: Self-Endangering Work Behavior as Novel Concept and Explanatory Mechanism

In a recently published article, Baeriswyl, Bratolic, and Krause introduced prolonging working hours as a coping behavior used by teachers, and using self-reported questionnaire-based data from 560 teachers in Switzerland, they demonstrated that it is related to emotional exhaustion-the core component of burnout. This Short Communication summarizes the most important findings from this focal article, embeds prolonging working hours into the concept of Self- Endangering Work Behavior (SEWB), and introduces the latest deliberations on SEWB. It outlines possibilities of measuring SEWB that may serve as a starting point for targeted activities in workplace health promotion in both schools and other occupational settings.