Miracle-dz/UniFAR-FTUs huggingface dataset:
The potential role of villin 1 and estrogen receptor (ER) in differentiation between endocervical adenocarcinoma and endometrial adenocarcinoma

Background: Endocervical adenocarcinoma (ECAC) is the 4th most common cancer in females globally. It has been ranked the 14th most common cancer in Egyptian females. The aim of this work was to study immunohistochemical expression of villin1 in endocervical and endometrial adenocarcinoma, immunohistochemical expression of ER in endocervical and endometrial adenocarcinoma and evaluate the potential role of villin 1 and ER expression in differentiation between endocervical & endometrial adenocarcinoma. Methods: This retrospective study was carried out on 60 cases of endocervical & endometrial endometroid adenocarcinoma. Patients were classified into two equal groups: Group I: Cases of endocervical adenocarcinomas and Group II: Cases of endometrial endometroid adenocarcinomas. Results: The positive predictive value of ER as a correlation between ER expression and clinicopathological characteristics has been addressed in our study was 100%. The negative predictive value was 73.1%. The positive predictive value of using panel of villin and ER expression and clinicopathological characteristics has been addressed in our study was 88.8%, the negative predictive value was 66.6%. Conclusions: Villin1 is good diagnostic tool had high specificity in differentiating endocervical and endometroid adenocarcinoma and has a predictive value in ECAC. ER is good diagnostic tool in differentiating between endocervical and endometroid adenocarcinomas and has predictive value in endometroid adenocarcinoma.
Rates of Developmental Disabilities Vary Across Birth Months in a Tropical Climate

Developmental disability rates may vary by the season or month in which children are born. However, the seasonal mechanisms, such as climate, underlying these variations are unclear. Previous studies focused on high-latitude regions, leaving this climate hypothesis only partially tested. We analyzed rates of developmental disabilities in 3- to 5-year-old children from a tropical climate—South Florida—from 2004 to 2015 (N = 79,047) using a time-series analysis to identify peaks in diagnoses based on birth months. Children with speech impairments were more likely to be born in March, April, and September, a novel finding. Children with developmental delays were more likely to be born in September and October, consistent with studies in colder regions. In contrast to prior studies, there were no effects of birth month for language impairment or autism spectrum disorder. We highlight potential prenatal mechanisms that may contribute to the seasonal variations in some developmental disabilities.
IMPROVEMENT OF THE RICHNESS ESTIMATES OF maxBCG CLUSTERS

Minimizing the scatter between cluster mass and accessible observables is an important goal for cluster cosmology. In this work, we introduce a new matched filter richness estimator, and test its performance using the maxBCG cluster catalog. Our new estimator significantly reduces the variance in the LX–richness relation, from to . Relative to the maxBCG richness estimate, it also removes the strong redshift dependence of the LX–richness scaling relations, and is significantly more robust to photometric and redshift errors. These improvements are largely due to the better treatment of galaxy color data. We also demonstrate the scatter in the LX–richness relation depends on the aperture used to estimate cluster richness, and introduce a novel approach for optimizing said aperture which can easily be generalized to other mass tracers.
Envy, Social Comparison, and Depression on Social Networking Sites: A Systematic Review

This study aims to review the evidence for the reciprocal relationship between envy and social comparison (SC) on social networking sites (SNSs) and depression. We searched PsychINFO, PubMed, and Web of Science from January 2012 to November 2022, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A total of 9 articles met our inclusion criteria. In all articles reviewed, a simple correlation was found between SC on SNSs, envy, and depression. Three cross-sectional studies successfully tested a model with envy as a mediator between SNSs and depression. The moderating role of additional variables such as self-efficacy, neuroticism, SC orientation, marital quality, and friendship type was also evident. The only two studies that were suitable to determine direction found that depression acted as a predictor rather than an outcome of SC and envy, and therefore depression might be a relevant risk factor for the negative emotional consequences of SNSs use.
Antidepressants and the Risk of Psoriasis Induction: A Case–Control Study

Background: Psoriasis (PSO) is a common chronic autoimmune skin disease with a significant psycho-socio-economic burden. Some antidepressants (ADs) such as fluoxetine and bupropion can induce or exacerbate PSO. This study aimed to investigate the correlation between ADs history before PSO onset, and the risk of PSO induction, in Isfahan province, Iran. Materials and Methods: In this case–control study, 80 patients with PSO were selected by non-probability sampling method, and 80 healthy individuals were selected using simple random sampling. They were interviewed and medical information was recorded. Chi-square, Mann–Whitney, and Kruskal–Wallis tests for dichotomous or categorical data, and independent-sample t test for continuous data were used. Statistical significance was taken as P ≤ 0.05. Results: In this case–control study, a total of 160 individuals, 80 participants in each group, were included. The mean age of the total samples was 44.8 ± 16 years. Forty-three percent of the individuals were women. PSO familial history in the cases was significantly higher than the control group (OR = 11.94, P = 0.001). It was revealed that use of ADs by patients before PSO induction, was greater than the controls (OR = 2.78, P = 0.058). Conclusions: Past history of ADs in the cases before PSO onset, was higher than the controls, indicating a possible association between ADs and the risk of PSO induction. This study can be effective to pay more attention to the possible complications of ADs and PSO risk factors. Accurate knowledge of PSO risk factors will be useful for better management and morbidity reduction.
Both ATM and DNA-PK Are the Main Regulators of HIV-1 Post-Integrational DNA Repair

The integration of a DNA copy of an HIV-1 RNA genome into the host genome, carried out by the viral enzyme integrase, results in the formation of single-stranded gaps in cellular DNA that must be repaired. Here, we have analyzed the involvement of the PI3K kinases, ATM, ATR, and DNA-PKcs, which are important players in the DNA damage response (DDR) in HIV-1 post-integrational DNA repair (PIR). The participation of the DNA-PK complex in HIV-1 PIR has been previously shown, and the formation of a complex between the viral integrase and the DNA-PK subunit, Ku70, has been found to be crucial for efficient PIR. Now, we have shown that the inhibition of both DNA-PKcs and ATM, but not ATR, significantly reduces PIR efficiency. The activation of both kinases is a sequential process, where one kinase, being activated, activates the other, and it occurs simultaneously with the integration of viral DNA. This fact suggests that the activation of both kinases triggers PIR. Most interestingly, the activation of not only DNA-PKcs, but also ATM depends on the complex formation between integrase and Ku70. The elucidation of the interactions between viruses and DDR is important both for understanding the modulation of host cell functions by these pathogens and for developing new approaches to combat viral infections.
First record of Gomphonema lacunicola Patrick et Freese (Bacillariophyta) from the Pâreng Mts (Southern Carpathians, Romania)

Here we report and document the occurrence of the diatom Gomphonema lacunicola Patrick et Freese 1961 from the Pâreng Mts of the Carpathian Mountains, Romania. This observation was made within the framework of a systematic sampling campaign and analyses that were conducted in the Southern Carpathians, covering 40 mountain lakes for discovering the cladoceran fauna and diatom flora of this region between 2012 and 2014. G. lacunicola was found only in one of the 40 lakes, namely in Lake Câlcescu, where it was extremely rare, but the characteristic feature of the lake promoted the presence of the species. Lake Câlcescu is a subalpine lake, located 1,934 m a.s. l. This is the first record of this diatom species in Romania.
Evidence for Endogenous Opioid Dependence Related to Latent Sensitization in a Rat Model of Chronic Inflammatory Pain

Studies performed in a mouse model of chronic inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant (CFA) have shown that constitutive activation of the endogenous opioid signaling, besides serving as a mechanism of endogenous analgesia that tonically represses pain sensitization, also generates a state of endogenous opioid dependence. Since species-related differences concerning pain biology and addictive behaviors occur between mice and rats, the present study explored whether the coexistence of endogenous opioid analgesia and endogenous opioid dependence also characterizes a homologous rat model. To this aim, CFA-injured Wistar rats were treated with either 3 mg/kg or 10 mg/kg of the opioid receptor inverse agonist naltrexone (NTX) during the pain remission phase and monitored for 60 min for possible withdrawal behaviors. At 3 mg/kg, NTX, besides inducing the reinstatement of mechanical allodynia, also caused a distinct appearance of ptosis, with slight but nonsignificant changes to the occurrence of teeth chatters and rearing. On the other hand, 10 mg/kg of NTX failed to unmask pain sensitization and induced significantly lower levels of ptosis than 3 mg/kg. Such an NTX-related response pattern observed in the rat CFA model seems to differ substantially from the pattern previously described in the mouse CFA model. This supports the knowledge that mice and rats are not identical in terms of pharmacological response and stresses the importance of choosing the appropriate species for preclinical pain research purposes depending on the scientific question being asked.
Asymptotic Properties of the Balanced Repeated Replication Method for Sample Quantiles

Inference, including variance estimation, can be made from stratified samples by selecting a balanced set of subsamples. This balanced subsampling method is generically called the balanced repeated replication method in survey data analysis, which includes McCarthy's balanced half-samples method and its extensions for more general stratified designs. We establish the asymptotic consistency of the balanced repeated replication variance estimators when the parameter of interest is the population quantile. The consistency results also hold when balanced subsampling is replaced by random subsampling. As a key technical prerequisite, we prove a Bahadurtype representation for sample quantiles in stratified random sampling.
Microstructure and Corrosion Performance of Carbonitriding Layers on Cast Iron by Plasma Electrolytic Carbonitriding

The surface carbonitriding of cast iron is investigated in an aqueous solution of acetamide and glycerin. Microstructure, chemical and phase composition and corrosion performance of the carbonitriding layers are investigated by scanning electron microscopy, energy dispersive spectroscopy and x-ray diffraction, as well as potentiodynamic polarization testing. X-ray diffraction results show that the carbonitriding coatings are composed of martensite, austenite(γ-Fe), Fe2C, Fe3C, Fe5C2, FeN and ∊-Fe2−3N. After the plasma electrolytic carbonitriding treatment the corrosion resistance of cast iron is clearly improved compared to the substrate, and the coatings produced at 350 V for 30s give the best corrosion resistance.
A similarity approach to turbulent sediment-laden flows in open channels

A basis is developed for a similarity treatment of the coupled mean fields in turbulent open-channel flows over a flat sand bed in equilibrium with a suspension of sand. Hypotheses involving multiple scales, asymptotic similarity, and matching over an overlapping region are made instead of the traditional dependence on eddy diffusion and Reynolds analogies. Velocity measurements using the laser-Doppler technique in experiments with well-sorted natural sands showed that, contrary to the implications of previous models, the effect of suspended sediment on the mean velocity profile may, over a variety of laboratory conditions, be confined to a layer adjacent to the bed. This is interpreted within the similarity framework in terms of the existence of an inner lengthscale, differing from either the viscous or the grain scale, associated with the presence of sediment. The suggested lengthscales and concentration scales are examined in light of the experimental results.
Dairy Cows Grazing Plantain-Based Pastures Have Increased Urine Patches and Reduced Urine N Concentration That Potentially Decreases N Leaching from a Pastoral System

Simple Summary Incorporating forage plantain into the diet of grazing dairy cows has the potential to reduce nitrogen (N) losses from pastoral systems. One of the key mechanisms for reduced N loss from plantain-fed cows is through increased urine volume and diluted urine N concentration, which increases the % of urine N used for plant growth. The aim of this study was to determine whether lower proportions of plantain in the diet would be effective in achieving changes in urination. The results showed that compared to cows grazing traditional perennial ryegrass and white clover pastures, cows with 25% plantain in their apparent dietary intake increased urine volume and urination frequency and reduced urine N% in the morning. When dietary plantain was less than 20%, there was only a small effect on increased urine volume, though morning urine N% was reduced. Ensuring more than 20% plantain in the diet has the potential to reduce N leaching risk via reduced urinary N load from grazing dairy cows. Abstract The objective of this study was to determine the effect of grazing plantain-based pastures on urine volume, urination frequency, and urinary nitrogen (UN) concentration of dairy cows under a typical pastoral dairy practice offering approximately 25% supplemented feeds. The experiment was a completely randomised design with three pasture treatments (perennial ryegrass–white clover (RGWC); RGWC + low plantain rate (PLL); and RGWC + high plantain rate (PLH)), five replicate plots, and repeated in two sequential grazing periods. Forty-five lactating Friesian × Jersey cows were randomly assigned into three groups of 15 animals each to graze over six days in adaptation paddocks and three days in experimental plots. Urine flow sensors were used to measure urine volume and urinary frequency, while spot urine sampling was conducted to determine nitrogen (N) concentration in cow urine. The results showed that including 25% plantain in the diet (PLH) increased daily urine volume by 44% and the daily number of urinations by 28%, compared to grazing the RGWC pasture. In addition, N concentration in cow urine was decreased by 18 and 29% when the diet contained 18% and 25% plantain, respectively. In conclusion, under a typical dairy farm practice, incorporating plantain into the RGWC pasture with the proportion of 25% plantain in the diet can increase the number of urine patches and reduce the concentration of N in the urine, thereby providing the opportunity to decrease N leaching from pastoral systems.
The MSSSO Wide Field CCD Hα Imaging Survey

Abstract A wide-field Hα survey of the Galactic Plane has been initiated by Mount Stromlo & Siding Spring Observatories in collaboration with the University of Sydney. The primary aim of the survey is to obtain images of the Galactic Plane in Hα and red continuum filters which will be compared with radio continuum images at 843 MHz from the Molonglo Observatory Synthesis Telescope (MOST). The secondary aim is to obtain images in [OIII] and [SII] to provide additional information on the nature of excitation in HII regions. Thirdly, additional images will be taken in B, V and I of interesting areas suitable for general publications as coloured reproductions. The images are taken with a 400 mm f/4·5 Nikkor-Q lens in conjunction with a 2K×2K SITe thinned CCD. The resolution is 12″ per pixel and the pixel size is 24 μm giving a 7°×7° field of view. Hα and red continuum observations are expected to be completed by the end of 1997. It is planned to make the results from the survey available on CD ROM and possibly video.
Pool Boiling Heat Transfer of Water on Finned Surfaces at Near Vacuum Pressures

This research paper presents a study of boiling heat transfer from longitudinal rectangular-finned surfaces immersed in saturated water at low vapor pressures. Finned surfaces with assorted fin spacing, fin thicknesses, and fin heights on a copper based surface have been investigated. All the finned surfaces were found to increase both boiling heat transfer coefficients and critical heat fluxes. An optimal fin thickness was found for a configuration, and heat transfer coefficients have been obtained at the pressures. Factors affecting the boiling characteristics have been identified and the optimal enhancement requires a balance of the active nucleation sites, bubble flow resistance, natural convection, thin film evaporation, liquid superheating, heat transfer area, bubble coalescence, and liquid reflux resistance. High speed visualization of vapor plug and vapor film generation on the boiling surfaces has revealed significant insights into the boiling mechanisms at low saturation pressures.
ONC201 for Glioma Treatment: Adding an Important Weapon to Our Arsenal

Glioma, specifically gliobastoma, represents the commonest central nervous system malignancy and is notoriously challenging to treat, with only a minimal number of patients surviving beyond a year after diagnosis. The available treatment options include surgical resection, radiotherapy, and chemotherapy, mainly with temozolomide. However, gliomas can be particularly treatment resistant and novel options are currently being researched. One such agent is ONC201, the first member of the imipridone class and a TNF-related apoptosis inducing ligand (TRAIL)-inducing compound, which has shown positive results in the first preliminary clinical reports about its application in glioma patients, while also being safe and well-tolerated. Particular promise has been shown for the H3K27M mutated glioblastomas, with more trials focusing on this patient subset. It is likely that this compound will be added in the treatment algorithms of glioma in the future, although more research is still needed.
Material, Electrical, and Optical Characterizations of High-K Sm2TiO5 Dielectric Deposited on Polycrystalline Silicon

This paper examines high-k Sm2TiO5 on polycrystalline silicon film treated in different annealing conditions and fabricated as a high-k gate dielectric. Material analyses, electrical characterizations, and optical measurements were performed to assess annealing effects and find an optimal annealing temperature. Results show that annealing at a temperature of 800°C effectively passivates defects such as dangling bonds and traps, and improves dielectric performance.
Disruption of the metC Gene Affects Methionine Biosynthesis in Pectobacterium carotovorum subsp. carotovorum Pcc21 and Reduces Soft-Rot Disease

Plant pathogenic Pectobacterium species cause severe soft rot/blackleg diseases in many economically important crops worldwide. Pectobacterium utilizes plant cell wall degrading enzymes (PCWDEs) as the main virulence determinants for its pathogenicity. In this study, we screened a random mutant, M29 is a transposon insertion mutation in the metC gene encoding cystathionine β-lyase that catalyzes cystathionine to homocysteine at the penultimate step in methionine biosynthesis. M29 became a methionine auxotroph and resulted in growth defects in methionine-limited conditions. Impaired growth was restored with exogenous methionine or homocysteine rather than cystathionine. The mutant exhibited reduced soft rot symptoms in Chinese cabbages and potato tubers, maintaining activities of PCWDEs and swimming motility. The mutant was unable to proliferate in both Chinese cabbages and potato tubers. The reduced virulence was partially restored by a complemented strain or 100 μM of methionine, whereas it was fully restored by the extremely high concentration (1 mM). Our transcriptomic analysis showed that genes involved in methionine biosynthesis or transporter were downregulated in the mutant. Our results demonstrate that MetC is important for methionine biosynthesis and transporter and influences its virulence through Pcc21 multiplication in plant hosts.
Cardiometabolic Risk and Its Relationship With Visceral Adiposity in Children With Cerebral Palsy

Abstract Context Adults with cerebral palsy (CP) display a higher prevalence of cardiometabolic disease compared with the general population. Studies examining cardiometabolic disease risk in children with CP are limited. Objective The purpose of this study was to determine if children with CP exhibit higher cardiometabolic risk than typically developing children, and to examine its relationship with visceral adiposity and physical activity. Methods Thirty ambulatory children with CP and 30 age-, sex-, and race-matched typically developing control children were tested for blood lipids, glucose, and the homeostatic model assessment of insulin resistance (HOMA-IR). Visceral fat was assessed using dual-energy x-ray absorptiometry. Physical activity was assessed using accelerometer-based monitors. Results Children with CP had higher total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol (non-HDL-C), glucose, prevalence of dyslipidemia, prevalence of prediabetes, and visceral fat mass index (VFMI) and lower physical activity than controls (all P < .05). In the groups combined, non-HDL-C and glucose were positively related to VFMI (r = 0.337 and 0.313, respectively, P < .05), and non-HDL-C and HOMA-IR were negatively related to physical activity (r = −0.411 and −0.368, respectively, P < .05). HOMA-IR was positively related to VFMI in children with CP (r = 0.698, P < .05), but not in controls. Glucose was not related to physical activity in children with CP, but it was negatively related in controls (r = −0.454, P < .05). Conclusion Children with CP demonstrate early signs of cardiometabolic disease, which are more closely related to increased visceral adiposity than decreased physical activity.
Ab initio estimates of the Curie temperature for magnetic compounds

The local spin-density functional approximation is increasingly being used for materials applications such as predicting structural and magnetic properties. The recently aquired ability to model low-lying magnetic excitations like magnons is used for deriving useful formulae to estimate the Curie (Néel) temperatures of magnetic compounds. Underlying this is Moriya’s unified approach, appropriately formulated for density functional use. The theory is applied to the classical compounds FeNi, CoNi, FeNi3, CoNi3, and RhMn3 to establish a level of confidence, and to the Heusler compounds NiMnSb, Mn2VAl, Co2FeSi, Mn3Al, and Mn3Ga, which are presently studied with possible applications in mind for advanced spin electronic devices.