Miracle-dz/UniFAR-FTUs huggingface dataset:
Visualizing Synaptic Transfer of Tumor Antigens Amongst Dendritic Cells

Generation of tumor-infiltrating lymphocytes (TILs) begins when tumor antigens reach the lymph node (LN) to stimulate T cells, yet we know little of how tumor material is disseminated amongst the large variety of antigen-presenting dendritic cell (DC) subsets in the LN. Here, we demonstrate that tumor proteins are carried to the LN within discrete vesicles inside DC and are then transferred amongst DC subsets. A synapse is formed between interacting DC and vesicle transfer takes place in the absence of free exosomes. DC containing vesicles can uniquely activate T cells whereas DC lacking them do not. Understanding this restricted sharing of tumor identity provides substantial room for engineering better anti-tumor immunity.
Linking Gender with Job Stress, Job Satisfaction, Job Performance, and Turnover Intention

Introduction : Job stress is one of the common psychological impacts due to demand and working environment in a workplace setting and the effect might be affected due to differences of gender. Purpose: The purpose of this paper is to study the relationship between job stress and job satisfaction, job performance, and turnover intention among government education sector employees, while testing the role of gender on the relationships between the variables. Methodology/Sample: A total of 244 government employees in the education sector in Selangor, Malaysia were invited to be participants using an anonymous self-reported questionnaire. The Job Stress Scale, the Minnesota Satisfaction Questionnaire, the Individual Work Performance Questionnaire 1.0 (IWPQ 1.0), and the Turnover Intention Scale were used as the instruments in this study. The data obtained were analysed by using Statistical Package for Social Sciences (SPSS) version 26 while and hypotheses testing and moderation analysis by using the Partial Least Square Structural Equation Modelling (PLS-SEM) via Smart-PLS version 4. Findings: The results showed that job stress is significantly positively related to job satisfaction and job performance. As for turnover intention, job stress is significantly negatively related to turnover intention. Gender was found to have no moderation effect towards the relationships. Originality/Value: We applied a theoretical explanation, which is the job-demand resource theory, to argue that excessive job demand will lead to stress and cause negative organisational outcomes, especially on job satisfaction, job performance, and turnover intention.
Transformation of Phosphorus Pools in an Agricultural Soil: An Application of Oxygen‐18 Labeling in Phosphate

Phosphorus is a key ingredient of fertilizers, and there is no other substitute for P in sustaining life and food production. Excess P in soils may be fixed and become agronomically inactive or removed as a result of leaching and soil erosion. In this research, we aimed to explore how a particular P pool transforms into another pool by applying ¹⁸O-labeled phosphate in an agricultural soil. We analyzed the changes in concentrations and phosphate O-isotope ratios (δ¹⁸OP) of four inorganic P (Pᵢ) pools (H₂O-Pᵢ, NaHCO₃–Pᵢ, NaOH-Pᵢ, and HCl-Pᵢ) along with soil chemistry to understand the roles of different biogeochemical processes changing isotope composition. By monitoring δ¹⁸OP values of four P pools, an active transformation from H₂O-Pᵢ and NaHCO₃–Pᵢ to NaOH-Pᵢ and HCl-Pᵢ was identified. Transformation of originally bioavailable P to unavailable P such as HCl-Pᵢ allowed us to conclude that a suite of HCl-Pᵢ with different δ¹⁸OP values could be precipitated from the originally biologically cycled or bioavailable P pools. Thus, the isotope technique allowed tracking of short-term transformation of readily bioavailable P to a less or non-bioavailable P pool and to discriminate biological and chemical reactions during transformation. These findings support the burgeoning applications of δ¹⁸OP as a tracer of P cycling in soil and are expected to be useful for fertilizer application as well as nutrient management in soils.
Investigating the Influence of Alkali over Morphology, Functional Groups, and Physical and Mechanical Properties of Fiber obtained from Cordia Dichotoma (Gum Berry)

Natural fiber is typically derived from plants that exhibit low density, lightweight, and abundant availability, along with the added advantage of being biodegradable. The Cardia Dichotoma plant's branches serve as a prominent source of natural cellulose fiber, offering a vast quantity for extraction. However, despite its hydrophilic nature, natural fiber exhibits poor compatibility with both fiber and matrix during the mixing process. To enhance its adhesive properties, the fiber undergoes a series of treatments, including Alkalization, Benzoylation, and Acetylation. In this research, the influence of alkali (untreated, 5%, 10%, and 15% NaOH) was investigated over morphology, functional groups, and physical and mechanical properties of fiber obtained from Cardia Dichotoma. SEM indicated bigger pore size, reduced thickness, and rough surface with etched striations in alkali-treated samples. FTIR peaks inferred that the use of alkali-receded hemicellulose, cellulose, and lignin. Tensile Force & Elongation at intervals showed that the mechanical properties of the increasing amount of Alkali reduced the mechanical properties of the fiber by 5 percent. Conclusively, 5% NaOH was found to be the optimum ratio that effectively removed hemicellulose, cellulose, and lignin, however, the higher percentage decreased tensile strength and elongation at break of the respective fiber.
RF Modeling and Measurements of a Reﬂectarray for Synthetic Aperture Radar for Earth Observations

—Design and simulation results of a polarisation-selective reﬂectarray in Ka band are presented. The reﬂectarray is part of a dual-offset antenna system for a high-resolution and wide-swath Synthetic Aperture Radar (SAR) instrument that operates in both a high-resolution mode with a directive beam in one polarisation, and a low-resolution mode with a broader beam in the orthogonal polarisation. Fed by orthogonal modes, a sectoral horn illuminates the reﬂectarray antenna with different beam widths for the two operational SAR modes. Radiation patterns of the feed and reﬂectarray antenna system are presented.
University of Birmingham Anticytomegalovirus antibody titres are not associated with caregiving burden in younger caregivers

Objective: This analysis examines whether or not younger caregivers, parents of children with developmental disabilities, differed from controls in terms of cytomegalovirus (CMV) seropositivity and CMV-specific antibody titre. Secondly, it examined whether any particular socio-demographics, health behaviours, or psychological/caregiving variables were associated with a higher CMV antibody titre among caregivers. Design: Young caregivers and age-and sex-matched controls were compared with respect to their reported health behaviour and psychosocial status as well as latent virus control. Methods: 117 parents of children with developmental disabilities and 52 control parents completed standard measures of health behaviours, socio-demographics, perceived stress, depression and anxiety, caregiver burden, child problem behaviours. They also provided a blood sample assayed for presence of CMV-specific antibody. Results: Caregivers were no more likely to be CMV positive than controls and did not have higher antibody titres against CMV. In addition, there was no association between CMV antibody titre in seropositive caregivers and any of the psychological/caregiving variables. However, higher CMV antibody titres were significantly associated with a higher BMI, lower exercise levels, smoking and lower fruit and vegetable and fat intake among seropositive caregivers. Conclusions: These data suggest that in the absence of immunosenescence, the chronic stress of caregiving is not sufficient to compromise the immune response to persistent CMV infection. However, an indirect mechanism to
Sequence stratigraphic framework for mixed aeolian, peritidal and marine environments: Insights from the Pennsylvanian subtropical record of Western Pangaea

Due to difficulties in correlating aeolian deposits with coeval marine facies, sequence stratigraphic interpretations for arid coastal successions are debated and lack a unifying model. The Pennsylvanian record of northern Wyoming, USA, consisting of mixed siliciclastic–carbonate sequences deposited in arid, subtropical conditions, provides an ideal opportunity to study linkages between such environments. Detailed facies models and sequence stratigraphic frameworks were developed for the Ranchester Limestone Member (Amsden Formation) and Tensleep Formation by integrating data from 16 measured sections across the eastern side of the Bighorn Basin with new conodont biostratigraphic data. The basal Ranchester Limestone Member consists of dolomite interbedded with thin shale layers, interpreted to represent alternating deposition in shallow marine (fossiliferous dolomite) and supratidal (cherty dolomite) settings, interspersed with periods of exposure (pedogenically modified dolomites and shales). The upper Ranchester Limestone Member consists of purple shales, siltstones, dolomicrites and bimodally cross‐bedded sandstones in the northern part of the basin, interpreted as deposits of mixed siliciclastic–carbonate tidal flats. The Tensleep Formation is characterized by thick (3 to 15 m) aeolian sandstones interbedded with peritidal heteroliths and marine dolomites, indicating cycles of erg accumulation, preservation and flooding. Marine carbonates are unconformably overlain by peritidal deposits and/or aeolian sandstones interpreted as lowstand systems tract deposits. Marine transgression was often accompanied by the generation of sharp supersurfaces. Lags and peritidal heteroliths were deposited during early stages of transgression. Late transgressive systems tract fossiliferous carbonates overlie supersurfaces. Highstand systems tract deposits are lacking, either due to non‐deposition or post‐depositional erosion. The magnitude of inferred relative sea‐level fluctuations (>19 m), estimated by comparison with analogous modern settings, is similar to estimates from coeval palaeotropical records. This study demonstrates that sequence stratigraphic terminology can be extended to coastal ergs interacting with marine environments, and offers insights into the dynamics of subtropical environments.
Effect of oxidative stress in semen, follicular fluid and embryo Effect of oxidative stress in semen, follicular fluid and embryo culture medium on the outcome of assisted reproduction culture medium on the outcome of assisted reproduction

Background: Although many advances have been made in the field of assisted reproduction, the clinical outcomes remain less than desirable. Oxidative stress has been recently blamed on both male and female partners. Aim of the study: This work aimed to study the effect of oxidative stress in semen, follicular fluid, and embryo culture medium on the outcome of assisted reproduction. Patients and Methods: Fifty couples with unexplained infertility were subjected to a combined treatment of IVF and ICSI. Oxidative stress was evaluated by measuring the oxidative-reduction potential (ORP) in the native semen sample, the follicular fluid pool and the spent culture medium of individually IVF cultured embryos. Results: ORP in the native semen was found to be a good predictor of fertilization and clinical pregnancy in IVF with a cut-off point of 1.57 and 0.75mV/10 6 sperm/ml, respectively. There was also a positive and highly significant correlation between the ORP levels in the follicular fluid pool and the fertilization rate ( r = 0.4217; P =0.002288), but there was no statistically significant difference between ORP in the follicular fluid pool of women who became pregnant and those who did not ( P = 0.997425). In addition, the mean ORP in the spent culture medium of women who became pregnant (215.78 mV/ml ± 38.52) was lower than in those who did not become pregnant (229.22 mV/ml ± 31.56) but the difference was also not statistically significant (P = 0.3170). Conclusion: It is concluded that ORP in the native semen and in the spent culture medium in IVF are good predictors of fertilization and clinical pregnancy and that ORP in the follicular fluid is not.
Dental care: the perception of pregnant women in Primary Health Care

The present study aimed to analyze the perspective of pregnant women on how dental care occurs in the context of Primary Health Care. This is a qualitative study through 16 semi-structured interviews with pregnant women in the second or third trimester of pregnancy, in a city in the countryside of São Paulo. The data was subjected to content analysis, thematic modality. It was observed that dental care in the Family Health Teams and Basic Health Units focuses on the general health of the pregnant woman and the fetus but has a weak focus on oral health. Pregnant women presented limitations related to oral self-care, as well as barriers that interfered with dental care during the gestational period. Despite identifying the importance of dental care during pregnancy, pregnant women face fears, fears, negative influences from relatives, lack of professional and care preparation, which limit the provision of prenatal dental care.
of hypoglycaemia in adolescents with type

Aims: To explore the relationship between diabetes self-management, and behavioural and emotional responses to hypoglycaemia in children and adolescents aged 8–15 years with type 1 diabetes via self-report measures. Methods: Data were collected at an overnight diabetes camp and endocrinology clinic on 127 participants who responded to two self-administered measures: the Diabetes Behavior Rating Scale (DBRS) and the Children’s Hypoglycemia Index (CHI). Descriptive statistics and linear regressions were analysed to detect significant relationships. Results and conclusions: Five items from the DBRS were found to predict 80% of the variability in self-management. Five items on the CHI predicted 90% of the variability in
Prevalence of diabetes mellitus and associated factors in adults: population-based survey

To estimate the prevalence of diabetes mellitus and associated factors in adults. Survey carried out with 1,637 individuals in urban and rural areas of the municipality of Rio Branco, state of Acre. Diabetes was defined by the presence of fasting plasma glucose ≥ 126 mg/dl or the use of oral hypoglycemic agents or insulin. Association measures were estimated by hierarchical logistic regression. The prevalence of diabetes was 6.5% (n = 202). After analysis, the chance of being diabetic was independently and positively associated with age ≥ 60 years (OR: 6.67; 95%CI: 1.83-24.30); family history of diabetes mellitus (OR: 2.88; 95%CI: 1.43-5.81); increased waist circumference (OR: 1.83; 95%CI: 1.01-3.33); dyslipidemia (OR: 2.95; 95%CI: 1.34-6.49); anemia (OR: 3.15; 95%CI: 1.30-7.60); and chronic kidney disease (CKD) (OR: 4.00; 95%CI: 1.70-9.33). A prevalence of 6.5% was detected, with diabetes associated with age, family history, anemia, and CKD. The need for adequate screening of comorbidities in these patients is indicated.
Evaluation of qPCR to Detect Shifts in Population Composition of Evaluation of qPCR to Detect Shifts in Population Composition of the Rhizobial Symbiont the Rhizobial Symbiont Mesorhizobium japonicum during Serial in during Serial in Planta Transfers Planta Transfers

Simple Summary: Rhizobia species that ﬁx atmospheric nitrogen in nodules that form on the root are very beneﬁcial to plant growth and productivity. Highly efﬁcient nitrogen-ﬁxing rhizobia developed under laboratory conditions often do not function at the same level in natural soils with native microbial communities. The aim of this research is to study how the plant ( Lotus japonicus ) associates with three rhizobia from the same species ( Mesorhizobium japonicum) when they are present together at the same time. These three rhizobia have different nitrogen-ﬁxing abilities, making them highly beneﬁcial (HB), moderately beneﬁcial (MB), and non-beneﬁcial (
EFFECTS OF OZONE ON EGG SHELL MICROBIAL LOAD, HATCHING TRAITS AND CHICK PERFORMANCE IN QUAIL EGGS

Objective: The aim of this study was to establish the effects of ozone on eggshell total aerobic mesophilic bacteria, egg weight loss, hatching traits, embryo deaths and chick performance. Methods: A total of 825 fresh hatching quail eggs were randomly distributed into five groups. Treatment groups were formed as control group (benzalkonium cloride application; C), 1% ozone application (O1), 3% ozone application (O3), 5% ozone application (O5) and 7% ozone application (O7). Results: There were no significant differences between the groups in terms of egg weight loss, hatching traits, embryo deaths, chick performance and livability. Ozone treatment had lower levels of total bacteria, especially in O7 group, than control eggs for the entire incubation period. Conclusion: As a result, the application of ozone can be used as an alternative to natural chemical disinfectant without adversely affecting the incubation results and chick performance.
ScholarWorks@CWU ScholarWorks@CWU

Three quarters of all Mw ≥ 6.6 earthquakes and volcanic eruptions surrounding the Caribbean plate occur preferentially during periods of decadal minima in Earth ’ s angular spin velocity. This correlation is revealed most clearly as a 4 – 6 years phase lag following the ﬁ rst derivative of the length of the day (LOD), Earth ’ s angular deceleration. We show that local strains and displacements resulting from oblateness changes, or plate boundary stresses associated with changes in tropical rotation rates are orders of magnitude lower than those typically associated with earthquake or volcano triggering. Notwithstanding the absence of a satisfactory causal physical mechanism, the relationship permits decadal trends in Caribbean tectonic hazards to be anticipated many years before their occurrence. The next period of increased tectonic activity in the Caribbean, corresponding to a probable slowing in Earth ’ s spin rate, will occur in the decade starting on or about 2030.
Wire Localization versus Intralesional Methylene Blue Marking for Surgical Excision of Impalpable Breast Lesions

Background: Preoperative marking of impalpable breast lesions is crucial for limiting false negative results and reducing the size of the resected breast tissue, thus improving cosmesis. The aim of this study was to evaluate wire localization versus intralesional methylene blue marking for surgical excision of impalpable breast lesions regarding the success of localization, cost, and limitations of both techniques. Method: This prospective cohort study included 50 patients with impalpable breast lesions or an area of suspicious microcalcification who were scheduled for surgical excision in the period between June 2020 and December 2021. Patients were randomly allocated into two groups: group I included 25 patients for surgical excision after preoperative ultrasound-guided methylene blue marking. Group II included 25 patients scheduled for surgical excision after preoperative guide wire localization under radiological guidance. Results: Localization by methylene blue injection has been associated with significantly shorter time of operation with mean duration ( P = 0.018) and much reduced cost in comparison with guide wire ( P < 0.001). Postoperative pain, reactions, ecchymosis, accuracy of localization, margin status, and patient satisfaction did not vary significantly between both groups. Conclusion: Localization by methylene blue injection is not only equally successful to guide wire in locating and identifying impalpable breast lesions for surgical excision, but also is significantly less costly and associated with a shorter duration of operation.
Journal Pre-proof Low Complication Rate Following Reverse Total Shoulder Arthroplasty at 90-Days Follow-Up – A Systematic Review

4 Importance: As Reverse Total Shoulder Arthroplasty (RTSA) has become an increasingly 5 common procedure rates of post-operative complications leading to potential hospital 6 readmission are of greater importance. No previous systematic reviews have focused 7 exclusively on post-operative complications and mortality rates at 90 days’ post RTSA. 8 Objectives: The purpose of this study was to review complication, readmission and mortality 9 rates within 90 days post RTSA. 10 Evidence Review: Two independent reviewers performed a literature search using the 11 Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines 12 using Pubmed, Embase and Web of Science databases. Only studies reporting on outcomes of 13 RTSA at 90-days follow-up specifically were considered for inclusion. 14 Findings: Our search included 79037 shoulders (62.1% female) from a total of 15 studies 15 with an average age of 72.4 ± 5.8 years. The overall 90-day re-admission rates were reported 16 in 9 studies as 6.1% (4205/69127) following RTSA. Additionally, a total of 5 studies reported 17 the overall 90-day mortality rate as 1.1% (19/1733). The overall pooled rate of medical 18 complications was 3.9%(2998/77826) as reported in 13 studies, at 90-days post-RTSA, with 19 the occurrence of anaemia being the most commonly reported outcomes as 20 2.9%(1013/34385) in 6 studies. The overall rate of surgical complications was 1.1% reported 21 in 13 studies (1327/77826), with the pooled rate of surgical revisions of 1.5% (607/40563) at 22 90-days follow-up. A total of 8, 5 and 3 studies reported rates of dislocation, requirement for 23 closed reduction and glenoid loosening as 0.9% (344/37995), 0.6% (7/1180), and 0.3% 24 (30/9115) respectively at 90-days following RTSA 25
BioassayCLR: Prediction of biological activity for novel bioassays based on rich textual descriptions

Screening molecules for desired biological activities with bioassays is at the core of the drug discovery process. The data produced by bioassays enable building quantitative structure-activity relationship (QSAR) models that are fundamental components of computer-aided drug discovery. Despite the advances brought by Deep Learning-based QSAR models, it is still unclear how to build these models for new bioassays for which no active nor inactive molecules are known. To ameliorate this problem, we propose BioassayCLR, a machine learning method that leverages rich textual bioassay descriptions for modeling. Our model takes as input both the chemical structure of a molecule and the textual description of the bioassay and outputs the predicted activity for this pair. The approach can be viewed as a contrastive learning approach in which representations of both molecules and bioas-says should be learned, which are similar if the molecule-bioassay pair is active and dissimilar if the pair is inactive. We perform experiments on bioassay descriptions and molecules from PubChem with 223,219,241 records of molecule-bioassay activity, corresponding to 2,120,811 unique molecules and 21,002 unique bioassays. On a strict temporal hold-out set with 615 unseen bioassays and 248,290 unseen molecules, BioassayCLR reaches an AUROC of 63.97 ± 0.47 outperforming the baselines using simple textual similarity by a margin, whereas all other QSAR methods yield random performance of 50.00. To our knowledge, this is the ﬁrst time that a textual representation of a bioassay is directly fed into a QSAR model and, thus, the ﬁrst method that can produce accurate predictions for bioassays that are only described by natural language. Because of these properties, our method allows for zero-shot transfer learning in drug discovery.