Miracle-dz/UniFAR-FTUs huggingface dataset:
Involvement of Polyamines in Physiological Reactions of Herbicide-treated Wheat Seedlings Subjected to Drought and Waterlogging Stress

Polyamines are plant growth regulators, which take part in plant growth and development, as well as in the physiological responses to diverse biotic and abiotic stresses. Drought and waterlogging are environmental stress factors that disturb normal plant growth. In our study, we determined the content of polyamines spermine, spermidine, and putrescine in young wheat seedlings (Triticum aestivum L., cv. Sadovo-1) pretreated with herbicide Serrate® (Syngenta) and subjected for 7 days to drought or waterlogging. We found that when applied alone the herbicide caused some decrease in polyamine levels but it was not substantial as compared to drought and waterlogging stresses. Obvious reduction of polyamine content was caused by both stress factors when applied alone or in combination with the herbicide. The decrease was more significant in drought-stressed seedlings than in waterlogged. When plants were transferred to normal irrigation regime the polyamine concentrations in drought-stressed plants tended to increase. The waterlogging stress continued to reduce polyamine content even during the recovery period. These data correlate with the growth parameters (fresh weight, height of shoots) indicating the involvement of polyamines in the physiological responses of herbicide-primed wheat seedlings under stress conditions.
A Real-World Study to Compare the Safety and Efficacy of Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir, with or without Ribavirin, in 587 Patients with Chronic Hepatitis C at the Fundeni Clinical Institute, Bucharest, Romania

Background In the European Union, a tablet with fixed doses of ombitasvir, paritaprevir, and ritonavir combined with dasabuvir is an authorized treatment for patients with chronic hepatitis C virus (HCV) infection. Ribavirin is a broad-spectrum antiviral used in several treatment regimens for patients with HCV infection. This real-world study aimed to compare the safety and efficacy of ombitasvir, paritaprevir, and ritonavir combined with dasabuvir, with or without ribavirin, in 587 patients with chronic hepatitis C attending the Fundeni Clinical Institute, Bucharest, Romania. Material/Methods This is an observational prospective study including 315 patients with F4 degree of fibrosis and compensated cirrhosis, 185 patients with F3 fibrosis, and 83 patients with F2 fibrosis. Liver fibrosis was evaluated by liver biopsy or Fibromax. Efficacy was defined as undetectable HCV-RNA at 12 weeks after the end of treatment. In terms of safety, we monitored the development of adverse reactions, liver cytolysis, cholestasis, and hematologic disorders. Results Of the 587 patients, 2 patients with B-cell lymphoma died during therapy. In total, 3/585 patients (0.51%) did not achieve sustained virologic response. Common adverse effects were nausea and asthenia (especially in patients with other medical treatments; P=0.03 and P=0.04, respectively) and anemia in patients who received ribavirin (P<0.01). None of the patients discontinued antiviral treatment. Patients with kidney transplant or end-stage kidney disease did not receive or discontinued ribavirin. Conclusions Ombitasvir, paritaprevir, and ritonavir combined with dasabuvir, with or without ribavirin had an efficacy rate of over 99% in HCV genotype 1b infection. We report no serious adverse reactions.
Prevalence of a Late Readiness Potential During a Deliberate Decision-Making Task

This study investigated the hypothesis that neural markers associated with arbitrary decision-making are present in higher order, deliberate decisions. Furthermore, the study aimed to investigate the effect of higher order decision content on neurophysiological markers such as the late readiness potential and the P300 potential. An experiment was designed to measure, evaluate, and compare these electroencephalographic potentials under both arbitrary and deliberate choice conditions. Participants were presented with legal cases and had to convict and acquit criminal offenders. Distinct readiness potentials and P300 potentials were observed for both arbitrary and deliberate decisions across all participants. These findings support the hypothesis that the readiness potential and the P300 potential are present in the neurophysiological data for higher order deliberate decisions. The study also showed initial findings of how the readiness potential may inherently relate to decision content. Increased readiness potential amplitudes were observed for participants with previous exposure to violent crime when they had to acquit or convict criminals accused of violent crimes.
A Psychoeducational CBT-based Group Intervention (“Drop It”) for Repetitive Negative Thinking: Theoretical Concepts and Treatment Processes

ABSTRACT Repetitive negative thinking (RNT)—such as worry and rumination—is an important transdiagnostic factor in the onset, course, and recurrence of depressive and anxiety disorders. This article describes a psychoeducational cognitive behavioral therapy (CBT)-based group intervention entitled “Drop It” that focuses exclusively on treating RNT in patients with major depressive disorder and/or generalized anxiety disorder. The theoretical concepts and treatment goals of the intervention are outlined. The organization and therapeutic processes of the different sessions are described and illustrated with statements of participants. Special attention is given to how the intervention capitalizes on the group structure and process to maximize the effectiveness of psychoeducation and CBT-based techniques. We also provide practical guidelines for clinicians treating patients with RNT.
Magnetic Resonance Spectroscopy in Diagnosis and Follow-Up of Gliomas: State-of-the-Art

Simple Summary Magnetic resonance spectroscopy (MRS) is a useful technique in diagnosis and follow-up of gliomas. In this review we provide an insight in the use of both proton and phosphorous MRS in clinical and scientific every day practice. Abstract Preoperative grade prediction is important in diagnostics of glioma. Even more important can be follow-up after chemotherapy and radiotherapy of high grade gliomas. In this review we provide an overview of MR-spectroscopy (MRS), technical aspects, and different clinical scenarios in the diagnostics and follow-up of gliomas in pediatric and adult populations. Furthermore, we provide a recap of the current research utility and possible future strategies regarding proton- and phosphorous-MRS in glioma research.
Enhanced Anomaly Detection System for IoT Based on Improved Dynamic SBPSO

The Internet of Things (IoT) enables smart settings, which help human pursuits. Although the IoT has increased economic opportunities and made numerous human conveniences possible, it has also made it easier for intruders or attackers to take advantage of the technology by either attacking it or avoiding it. Therefore, the primary concerns for IoT networks are security and privacy. For Internet of Things (IoT) networks, several intrusion detection systems (IDS) have been developed thus far using various optimization techniques methods. But as data dimensionality has increased, the search space has grown significantly, offering difficult problems for optimization techniques like swarm optimization using particles (PSO). To overcome these obstacles, this work suggests an approach for feature selection dubbed enhanced to increase the sticky binary dynamic sticky binary particle swarm optimization's searchability, and particle swarm optimization (IDSBPSO) was developed. It introduced a method for decrease of the dynamic search space and various dynamic parameters (SBPSO). To identify malicious data flow in IoT networks, an IDS was developed using this methodology. The IoTID20 and UNSW-NB15 IoT network datasets were used to assess the proposed model. It was found that, even with less features, IDSBPSO typically attained accuracy that was either higher or comparable. Moreover, as compared to traditional IDSBPSO and PSO-based feature selection methods dramatically reduced computational cost and prediction time.
Depression and its socio-demographic correlates among urban slum dwellers of North India: A cross-sectional study

Background: Depression is a common mental health disorder that is characterized by loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, low energy, and poor concentration, insomnia or hypersomnia, and occasionally suicidal thoughts. Apart from biological factors, sociocultural factors also play a key role in development of depression Objectives: To determine the prevalence of depression in the study population and to study various socio-demographic correlates of depression in the study population. Methods: A community based cross-sectional study was carried out in an urban slum area of Rohtak city during 2016-2017. A total of 600 study participants were selected and interviewed by using PHQ-9 depression scale. The collected data were entered in MS Excel spread sheet and analysed using SPSS software version 20.0. Results: Mean age of the study participants was 37.91 ± 11.75 years. Almost all (97.5 %) study subjects were Hindu. Majority (52 %) belonged to General category. Overall prevalence of depression was found to be 16.2%. The distribution for factors like gender, marital status, education, occupation, socioeconomic status, type of family, living arrangement, smoking habit and death of close relatives were found to be statistically significant with depression (P<0.05). Logistic regression analysis showed that female gender, divorce/separation, illiteracy, unemployment, lower socioeconomic class nuclear family living alone, smoking habit, presence of chronic morbidity and death of close relative in past one year, as independent predictors of depression. Conclusions: The prevalence of depression among adults in an urban slum of north India was found to be 16.2%. Our findings indicate that depression in urban slum is significantly associated with determinants such as gender marital status, education, occupation, SE class, family type, smoking, living arrangement, death of close relative, chronic morbidities like neurological disorders, diabetes and hypertension.
Granulosa Cells Improved Mare Oocyte Cytoplasmic Maturation by Providing Collagens

Assisted reproductive technology has important clinical applications and commercial values in the horse industry. However, this approach is limited largely by the low efficiency of oocyte in vitro maturation (IVM), especially cytoplasmic maturation. To improve the efficiency of mare oocyte IVM, we evaluated the effects of co-culture with cumulus–oocyte complexes (COCs) and granulosa cells (GCs) from follicles with small (<15 mm) and large diameters (>35 mm). Our results showed that oocyte nucleus maturation was not significantly improved by co-culturing with GCs. Interestingly, the cytoplasmic maturation of oocytes, defined by the distribution of cortical granules and mitochondria, as well as reactive oxygen species (ROS) levels, improved dramatically by co-culture with GCs, especially those derived from small follicles. Moreover, GCs promoted cumulus cell expansion by upregulating the expression of BMP15 in oocytes. To determine the mechanism underlying the effects of GCs, the transcriptomes of GCs from large and small follicles were compared. Expression levels of COL1A2, COL6A1, and COL6A2 were significantly higher in GCs from small follicles than in those from large follicles. These three genes were enriched in the extracellular matrix proteins-receptor interaction pathway and were involved in the regulation of collagens. Taken together, our results suggest that co-culture with GCs is beneficial to oocyte cytoplasmic maturation, and the increased expression of COL1A2, COL6A1, and COL6A2 improve the mare oocyte IVM system via the regulation of collagen.
FACTORS THAT INFLUENCE THE INTEREST IN THE UTILIZATION OF SHARIA FINANCIAL TECHNOLOGY ON MILLENNIALS AND GENERATION Z

The purpose of this research is to analyze the effect of perceived ease of use, perceived benefits, perceived risk, trust, and religiosity on behavioral intentions of Islamic financial technology in the millennial generation and Generation Z in Kuningan Regency. The type of research used is quantitative research, with descriptive and verification research methods. The primary data in this study were obtained by using a questionnaire distributed through Google Form. The population in this study is the millennial generation and Generation Z in Kuningan Regency with a research sample of 125 respondents. The sampling method used in this research is non-probability sampling with a purposive sampling technique. The data analysis technique used is Structural Equation SEM-PLS. Results of this study indicate that the variables of perceived ease of use, perceived benefits, perceived risk, trust, and religiosity have a significant positive effect on behavioral intentions of Islamic financial technology in the millennial generation and generations in Kuningan Regency.
Effect of antibiotic therapy in the postoperative period of third molar surgeries: a split-mouth, randomized and controlled study

Purpose: The objective of this randomized clinical trial was to evaluate the postoperative period of 32 third molars, semi-included or included, in a split mouth, of patients from the São Paulo State University. Material and Methods: The teeth were divided into two groups, in the test group drug treatment with Amoxicillin 500 mg, Dexamethasone 4 mg and Dipyrone 500 mg and in the control group patients received treatment with Dexamethasone 4 mg and Dipyrone 500 mg. The parameters used were edema, trismus and pain, measured before and after the operation, where the benefits of antibiotic therapy were evaluated. To compare the data, an analog pain scale was used, the method of Ustün, and the millimeter ruler, being submitted to Student's T test. Results: Both test and control groups had similar values, with no statistically significant difference in the incidence of postoperative complications, as well as in the presence of edema, pain and more pronounced trismus between the groups analyzed in the study. Conclusions: In view of the statistical results obtained, it was not possible to state that the use of antibiotic therapy was beneficial when related to edema, trismus and pain.
Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11

Gene therapy for genetic hearing loss is an emerging therapeutic modality for hearing restoration. However, the approach has not yet been translated into clinical application. To further develop inner-ear gene therapy, we engineered a novel mouse model bearing a human mutation in the transmembrane channel-1 gene (Tmc1) and characterized the auditory phenotype of the mice. TMC1 forms the mechanosensory transduction channel in mice and humans and is necessary for auditory function. We found that mice harboring the equivalent of the human p.N199I mutation (p.N193I) had profound congenital hearing loss due to loss of hair cell sensory transduction. Next, we optimized and screened viral payloads packaged into AAV9-PHP.B capsids. The vectors were injected into the inner ears of Tmc1Δ/Δ mice and the new humanized Tmc1-p.N193I mouse model. Auditory brainstem responses (ABRs), distortion product otoacoustic emissions (DPOAEs), cell survival, and biodistribution were evaluated in the injected mice. We found broad-spectrum, durable recovery of auditory function in Tmc1-p.N193I mice injected with AAV9-PHP.B-CB6-hTMC1-WPRE. ABR and DPOAE thresholds were equivalent to those of wild-type mice across the entire frequency range. Biodistribution analysis revealed viral DNA/RNA in the contralateral ear, brain, and liver but no overt toxicity. We conclude that the AAV9-PHP.B-CB6-hTMC1-WPRE construct may be suitable for further development as a gene therapy reagent for treatment of humans with genetic hearing loss due to recessive TMC1 mutations.
Difficulties of translation and evaluative idioms in English and Arabic

Essentially, translation is not simply a transfer of every word with its equivalent in the target language, but rather a transfer of the rules of the language that communicate the information and the transfer of the same information and the writer’s thought, culture and style as well. However, theories differed in translation on how to transfer this information from the source to the target. The trinity of translation: literal or word by word, free (significant) and faithful translation. The aim of this article is to discuss evaluative idioms in English and Arabic to show difficulties that form issues for translating idioms—from a variety of perspectives, focusing mainly on Moon’s 1998 approach and on Abdou’s 2012 study of Arabic idioms. Furthermore, to show the comparison between evaluative idioms in the two languages is meant to reveal differences and potential difficulties for translators translating from Arabic into English and vice versa, focusing mainly on Moon’s 1998 approach and on Abdou’s 2012 study of Arabic idioms. Furthermore, to show the comparison between evaluative idioms in the two languages is meant to reveal differences and potential difficulties for translators translating from Arabic into English and vice versa.
The hyporheic zone as an invertebrate refuge during a fine sediment disturbance event

Subsurface sediments offer an important refuge that support the survival and persistence of river invertebrates during adverse surface conditions. Access to refuges for invertebrates varies with differing hydrological and substrate characteristics, especially the proportion of fine sediment. This study examines whether substrate characteristics influence the use of the hyporheic zone as an invertebrate refuge during a fine sediment disturbance event. We used 12 outdoor stream mesocosms to examine the vertical migration of benthic and hyporheic invertebrates to fine sediment loading. Each mesocosm was filled with coarse or experimentally colmated sediments. After 69 days, a fine sediment pulse of three varying fine sediment concentrations was added to the stream mesocosms. Both before and after the fine sediment pulse, a distinct gradient in the abundance and richness of hyporheic invertebrates was apparent with depth. Hyporheic abundance and taxonomic richness decreased at 5 cm and increased at 18 cm during fine sediment loading, indicating vertical migration of invertebrates from the benthic to hyporheic zone. Our study provides support for the hyporheic zone as a refuge for benthic invertebrates during fine sediment disturbance events. We also found evidence that movement pathways within subsurface sediments were still accessible and permitted bidirectional migration of individuals between the benthic and hyporheic zone in the coarse and colmated sediments during fine sediment loading. Understanding how increased fine sediment deposition affects streambed porosity will be increasingly important with ongoing climate change and anthropogenic sedimentation.
Electrocardiographic and echocardiographic findings in children with dengue infection

Background: The mechanism of myocardial damage in dengue could be the release of inflammatory mediators or the direct action of the dengue virus on myocytes leading to myocarditis. The release of inflammatory mediators is more in a severe form of the disease that correlates to the higher incidence of cardiac manifestations in patients with severe dengue. Aim: To determine the electrocardiographic and two-dimensional (2D)-echocardiographic findings in children with dengue infection and to find a correlation with disease severity. Materials and Methods: A total of 150 children between 1 month and 12 years of age seropositive for dengue Non-specific antigen 1 (NS1) Enzyme linked immunosorbent assay (ELISA) or dengue Immunoglobulin M (IgM) ELISA were studied in the Department of Pediatric Medicine of a tertiary care government hospital. The patients were undertaken for 12 lead electrocardiograms (ECGs) and echocardiograms. Results: Out of the 150 dengue seropositive cases, 61 cases were of mild dengue, 67 cases were of dengue with warning signs (DWSS), and 22 cases were severe dengue cases. Abnormal ECG was found in 78 cases (52%) in a total of 150 cases in terms of rate, prolonged PR interval (interval between atrial depolarization and ventricular activation), ST (ventricular repolarisation)-segment depression, and low-voltage complexes. Abnormal 2D- echocardiography (ECHO) was found in 70 (46.6%) out of 150 in terms of the ejection fraction (EF) <55%, Early diastole/atrial contraction (E/A) ratio <1, and the presence of pericardial effusion. Conclusion: Nearly 50% of the patients have abnormal ECG and ECHO findings, more so in the severe dengue group. There is a statistically significant association of the EF between mild dengue, DWWS with severe dengue (P =0.001).
Perceptions of Computer-assisted Interpreting Tools in Interpreter Education in China’s Mainland: Preliminary Findings of a Survey

Computer-assisted interpreting (CAI) tools are increasingly used particularly for terminology accuracy and efficiency. However, the perceptions of the usefulness of CAI tools’ are mixed. This article analyses the perceptions of CAI tools in interpreter training based on the findings of a survey distributed to interpreter trainers and trainees in China. Analysis of the 161 responses shows that most respondents are interested in CAI but there is no relevant course available on BA- or MA-level interpreter programs yet while students are keen to learn CAI tools in preparation for the future market. Secondly, the most frequently used CAI tool among Chinese interpreter trainees remains online dictionaries whereas the arguably most frequently used terminology management tool in Europe, InterpretBank, is not even in the toolkit of Chinese interpreters. User feedback shows CAI tools mainly help with interpreting preparation, especially in the science and technology domain. Thirdly, it is recommended that CAI be integrated into China’s interpreter education, even though some interpreter trainers have argued about the importance of developing interpreting skills in the first instance. Informed by the findings of the study, this article contributes to the discussion of the possibility of future integration of CAI in interpreter education.
Effects of Task Performance Expectancy Violations on Processing Fluency and Speaker Evaluations

We examined how task performance expectancy violations influence speaker evaluations. Americans listened to a Japanese-accented speaker reading a story; completed a memory test on the story's content; indicated their expected performance on the test; and then received positive, negative, or no performance feedback. Positive feedback positively violated listeners’ performance expectancies and elicited higher fluency, a more positive affective reaction, and more positive speaker evaluations, compared to no feedback. Fluency and affect mediated the effect of positive feedback on speaker evaluations.