Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical PD-1/PD-L1 Blockades in Combination Therapies for Lymphomas

Simple Summary Immunotherapy using antibodies against programmed cell death protein 1 (PD-1) or its ligand PD-L1 can restore host antitumor immunity in many types of cancer. Hence, PD-1/PD-L1 blockade therapy has become the standard treatment for various cancer types in the last decade. However, apart from classic Hodgkin lymphoma and primary mediastinal B-cell lymphoma, PD-1/PD-L1 blockade therapy has shown limited efficacy in other lymphomas. To address this gap, several clinical trials of combination therapies with PD-1/PD-L1 inhibitors have been recently conducted or are underway in both frontline and relapsed/refractory settings. Here, we comprehensively review these clinical studies of combination therapies for lymphomas and discuss their outcomes in the hope of providing a perspective to develop novel therapeutic approaches for combination therapy. Abstract Immunotherapy with the programmed cell death protein 1 (PD-1)/PD-1 ligand (PD-L1) blockade has revolutionized the treatment of advanced solid cancers. However, these clinical benefits have been limited to cases of malignant lymphomas, showing promising results for only classic Hodgkin lymphoma (cHL) and primary mediastinal B-cell lymphoma (PMBCL). To bring clinical benefits to more patients with lymphoma, numerous combination therapies involving PD-1/PD-L1 blockade have been tested in clinical trials in both frontline and relapsed/refractory settings. This article reviews the current landscape of combination therapies with PD-1/PD-L1 blockade for lymphoma and discusses the potential therapeutic approaches. An interim analysis of a phase 3 study demonstrated increased progression-free survival with nivolumab combination therapy over the current frontline treatment in patients with advanced-stage cHL. The results of combination therapies for aggressive B-cell lymphomas, except for PMBCL, have been disappointing. Several clinical trials of combined PD-1/PD-L1 blockade and Bruton’s tyrosine kinase inhibitors are exploring its efficacy in patients with chronic lymphocytic leukemia (CLL) with Richter transformation. Several T-cell lymphoma subtypes respond to PD-1/PD-L1 blockade monotherapy. Further clinical trials are underway to investigate appropriate combination regimens with PD-1/PD-L1 blockade, especially for cHL, CLL with Richter transformation, and T-cell lymphoma, in both frontline and relapsed/refractory settings.
The Impact of the Little Miami Scenic Trail on Single Family Residential Property Values

Across the United States, many conversions of abandoned railroad rights-of-ways into trails have faced opposition from surrounding property owners. Much of the opposition derives from the fear that developing trails would cause a decrease in property values because of loss of privacy, increase in noise, traffic, litter and crime. The objective of this study is to assess the impact of the Little Miami Scenic Trail on property values. To accomplish this task, the hedonic pricing technique was employed to measure the impact of the trail on single-family residential property values in southwest Ohio. Several of the variables used in this model were measured using Geographic Information Systems (GIS) software. The analysis suggests that, each foot increase in distance to the trail decreases the sale price of a sample property by $7.05. In other words, being closer to the Little Miami Scenic Trail adds value to the single family residential properties.
Information Integration of Environmental Preservation Messages to the Students as Young Generations in Gorontalo City

This study analyzes three problems, knowledge, behavior, and media habits, to collect information about environmental preservation. The purpose is to form a strategy for a safe environment based on the data obtained and described. The theory used in this research is integration information theory. The research population is young generations in UNG, and the sample is active students from the Department of Communication at UNG. This study uses a combination of closed and open questionnaires. The results of the research show that the level of knowledge is sufficient. Regarding behavior, students still disagree on several things, such as bringing tumblers to campus. On the other hand, students are supportive if campuses hold open green spaces, create learning curricula about environmental communication, and make policies related to green campuses. Media habits show that students consume more information from social media and entertainment, so environmental preservation information must be included. Therefore, advice was given to the government in Gorontalo to involve young people in preservation programs; mass media, which is more neutral in reporting about the environment; and universities that are starting to improve regarding environmental preservation.
Wind- and Density-Driven Circulation in a Well-Mixed Inverse Estuary

Abstract Near the ocean, the residual circulation in Laguna San Ignacio, located on the Pacific coast of Baja California in Mexico, has been shown to be driven by tides. Here the subtidal circulation in the portion of the lagoon farther from the ocean is shown to be driven by the wind. The pressure difference between two stations, one near the closed end and the other midway along the central axis, is correlated well with the wind stress, in the sense that sea level rises downwind. Where the bathymetry is relatively simple, with a deep channel separating two shoal areas, the flow is upwind at the deepest part of the section, driven by the axial pressure gradient. In areas where the bathymetry is more complex, the direction of the observed flow is parallel neither to the local bathymetry nor to the applied wind stress. Linear theory qualitatively explains the major features of the wind-driven flow, including the relative strength of the pressure gradient to the wind stress, the direction of the flow, and t.
Association of Big Data with Sustainable Competitive Advantage in Online Retail Segment: A Serial Mediation Model for Relating Big Data with Strategic Management Tools

Purpose: Big-Data is one of the most studied and researched topics of recent times. The tool has been studied vastly in the western world. However, the domains were either related to science and technology, although there is a need to relate Big Data to strategic management and competitive advantage to remove the lack of research in that vein. Methodology: This study is systematically conducted to explore the effect of big data on the attainment of business improvement in the online retail segment. The model has been developed through an in-depth literature review to relate the resource-based view with the attainment of sustainable competitive advantage through serial mediation of big-data analytics knowledge and innovative capabilities. Data was collected through non-probability sampling from IT managers and specialists associated with the online retail segment and analysis was conducted through SMART-PLS. Findings: Results indicated that big data is for the improvement of business for the online retail segment. However, data availability is a must for applying big-data analytics toward sustainable competitive advantage. Conclusion: This study concludes that all the relations and indicates that Bug-Data is fruitful for booting advanced knowledge and innovative capabilities. However, the onlin IT sector needs to have some other elements like advanced IT skills to legitimize the relationship
Study on Loading Distribution Law on Key Roof and Its Structure Upon Mining Face Under Thick Sandy Layer

Based on the measurement in site, the phenomenon of load reducing on roof key blocks structure under thick sandy soil layer was discovered. By dynamic load simulating model tests of the roof structure, it is found that the mined failure feature of thick sandy soil layer are arch, arch shell and arch pillar. Then, the general load distribution law on the mined key roof and its structure under thick sandy soil overburden were educed, and the dynamic load distribution on A, B and C key blocks of roof structure was revealed. Furthermore, the load transmitting mechanism is the modified "unloading arch" in roof period weighting, and the new concept of load transmitting factor was set up. Based on that, the formulae of lithology factor and time factor of load transmitting were established. By means of these formulae, the problem of load calculation for roof key block can be solved.
Unmasking the Enigma of the COVID Toe

In 2020, the world encountered a new infection known as COVID-19. As a result, people started experiencing various COVID manifestations, aftereffects, and sequelae, one of which is the COVID toe, a rather uncommon presentation. Chilblain-like lesions, commonly referred to as 'COVID toe' due to their high occurrence on toes and fingers, can develop in any age group but are most commonly seen in younger adults. A 35-year-old female presented with painful pinkish-purple discoloration of her toes a week after acquiring a COVID-19 infection. Following this, she underwent blood tests and scans to rule out vasculitis and other autoimmune illnesses. The case highlights the distinctive presentation of this condition and its unusual appearance. This emphasizes that the COVID toe can vary from person to person, and not all cases are self-limiting. Depending on the presentation and the duration of symptoms, one may need to consider more extensive treatment, as not all cases resolve by themselves. This case report was presented as a poster at the Acute and General Medicine Conference in London, United Kingdom.
A review on the role of soil microbial biomass in eco-restoration of degraded ecosystem with special reference to mining areas

Soil microbial biomass constitutes a transformation matrix for all the natural organic material in the soil and acts as labile reservoir of plant available nutrients. In general plants serve as carbon source for the microbial community and in turn microbes provide nutrients for growth through mineralization of plant and animal residues, and organic matter, thus soil microbial biomass is a significant parameter to draw an inference about the soil health. Biodiversity of visible plants and animals has received a greater attention than the meso or micro level organisms. Information about soil microbial biomass can help to quantify the extant of degradation and may help to provide the effective methodology for the restoration in the degraded terrestrial ecosystems. As the changing global climate has been one of the major environmental challenges facing the world today, there is an increasing need to restore the degraded ecosystem, increase their productivity, to increase the carbon sequestration potential of such areas and to make them suitable for the sustainable forestry purposes. This review provides the importance of soil microbial biomass in the derelict mined ecosystems and suggests that an increase in microbial biomass in the soil may enhance the soil fertility, and provide an effective substrate for the nutrient mineralization.
Drug delivery for neurodegenerative diseases is a problem, but lipid nanocarriers could provide the answer

Neurodegenerative disorders encompass diseases that involve the degeneration of neurons, particularly those within the central nervous system. These are the most commonly observed disorders among the geriatric population. The treatment or management of this condition presents additional challenges due to therapeutics that may not be as effective as desired. The primary obstacle that often hinders the efficacy of therapy is the existence of a blood-brain barrier (BBB). The BBB serves as a vital safeguard for the brain, effectively obstructing the passage of drugs into the brain cells. Hence, the management of damaging neurodegenerative conditions such as Alzheimer's disease (AD), Parkinson's disease (PD), Cerebrovascular diseases (CVDs), Huntington's disease (HD), and Multiple sclerosis (MS) is currently the primary area of research interest. The innovative utilization of nanoparticles as drug carriers provides renewed optimism in addressing many complicated medical conditions. In this article, I have aimed to gather published information regarding various lipid nanoparticles that can efficiently transport medication to the brain to address neurodegenerative disorders. According to the published literature, liposomes, solid-lipid nanoparticles, nanostructured nanoparticles, microemulsions, and nanoemulsions are potential nanocarriers that can treat neurodegenerative disorders.
Neutrophils in Inflammatory Diseases: Unraveling the Impact of Their Derived Molecules and Heterogeneity

Inflammatory diseases involve numerous disorders and medical conditions defined by an insufficient level of self-tolerance. These diseases evolve over the course of a multi-step process through which environmental variables play a crucial role in the emergence of aberrant innate and adaptive immunological responses. According to experimental data accumulated over the past decade, neutrophils play a significant role as effector cells in innate immunity. However, neutrophils are also involved in the progression of numerous diseases through participation in the onset and maintenance of immune-mediated dysregulation by releasing neutrophil-derived molecules and forming neutrophil extracellular traps, ultimately causing destruction of tissues. Additionally, neutrophils have a wide variety of functional heterogeneity with adverse effects on inflammatory diseases. However, the complicated role of neutrophil biology and its heterogeneity in inflammatory diseases remains unclear. Moreover, neutrophils are considered an intriguing target of interventional therapies due to their multifaceted role in a number of diseases. Several approaches have been developed to therapeutically target neutrophils, involving strategies to improve neutrophil function, with various compounds and inhibitors currently undergoing clinical trials, although challenges and contradictions in the field persist. This review outlines the current literature on roles of neutrophils, neutrophil-derived molecules, and neutrophil heterogeneity in the pathogenesis of autoimmune and inflammatory diseases with potential future therapeutic strategies.
Seasonal benthic species composition linked to coastal defense structures (CDS) in Kuala Nerus, Terengganu, Malaysia

Background The natural hydrodynamic process of Kuala Nerus, Terengganu, has changed since the extension of Sultan Mahmud Airport runway in 2008. Consequently, severe coastal erosion has occurred in the area, particularly during the northeast monsoon season (NEM). Numerous types of coastal defense structures (CDS) have been constructed to protect the coastline. Despite the loss of esthetic values, the effect of CDS construction on marine organisms in the area remains unknown. Hence, this study aims to assess the ecological aspects of macrobenthic compositions at the CDS area of Kuala Nerus, Terengganu, based on the differences between the southwest (SWM) and northeast (NEM) monsoon seasons. Methods Macrobenthos were collected from the sediment in July (SWM) and December 2021 (NEM) using the Ponar grab at 12 substations from five sampling stations. Results The density of macrobenthos was higher in SWM (48,190.82 ind./m2) than in NEM (24,504.83 ind./m2), with phylum Mollusca recording the highest species composition (60–99.3%). The macrobenthos species had a low to moderate level of diversity (H’ = 1.4–3.1) with the species were almost evenly distributed (J’ = 0.2–0.8). Windward substations exhibited coarser grain sizes (38.56%–86.84%), whereas landward substations exhibited very fine grain sizes (44.26%–86.70%). The SWM season recorded a higher organic matter content (1.6%–6.33%) than the NEM season (0.4%–3.1%). However, metal concentrations in the surface sediment were within the safe range and permissible limits for both seasons, inferring that the macrobenthos composition was unaffected. Discussion This study demonstrated that the CDS associated with the monsoon system has controlled the hydrodynamics and nearshore sedimentary processes in the Kuala Nerus coastal zone, thereby affecting the macrobenthos population, in terms of richness and density. The ecological and energetic effects of the coastal structures in different seasons have resulted in a more significant result, with the SWM exhibiting a higher macrobenthos composition than the NEM.
Subjective Well-Being and Mental Health of Puerto Rican Post-Disaster Migrants

Prior research has explored the relationship between disasters and the personal well-being of migrants in the United States. The current study retrospectively evaluates the subjective well-being of Puerto Rican post-disaster migrants before migration, after migration (and after the return migration to Puerto Rico of a small subset of the sample), and during the COVID-19 pandemic. Utilizing both Wilcoxon Signed Rank and independent samples t-tests, we find that stateside and return migrants experience declines in self-reported mental health after migration and return migration (before the COVID-19 pandemic) and during the pandemic. In addition, we find that return migrants report worse mental health, more negative emotions, and fewer positive emotions than migrants who remained stateside. Our findings have implications for our understanding of Puerto Ricans’ subjective well-being and mental health. Directions for future research on post-disaster climate migration, and particularly the subjective well-being of return migrants, are discussed.
Carbonised Cereals from Grooved Ware Contexts

In their report of Durrington Walls, Wainwright and Longworth (1971) comment ‘It is noteworthy that not one certain grain impression has been recorded on any Grooved Ware sherds, nor is there any other evidence for the cultivation of cereals’. They conclude that the economy of Grooved Ware cultures is based on pastoralism and strandlooping rather than agriculture, and this conclusion has been generally accepted. Two points may be raised about this conclusion. First, the absence of grain impressions need not imply the absence of cereal cultivation. Hubbard (1975) has convincingly argued that the occurrence of pottery impressions does not provide the representative picture of crop economy suggested by Jessen and Helbaek (1944, 28). Such variables as the nature of the refuse deposited in the potter's working area and the degree of cleanliness required by the potter in his work will strongly influence the occurrence of impressions. For example, Hubbard has suggested that the sharp decrease in the frequency of impressions of emmer wheat in the Bronze Age may reflect its careful storage for human consumption, in contrast to barley which, as animal feed, would be more likely to get scattered around the site and incorporated into pottery. The second point concerns the apparent absence of carbonised grain. This may be an illusory consequence of inadequate methods of retrieval in the field. Over the last decade, the use of water flotation has demonstrated that carbonised grain and seeds are many times more common than had previously been thought (Jones 1978).
Transition to El Niño conditions in the eastern tropical Pacific in October 2015

A strong El Niño developed in early 2015. Measurements from a research cruise on the RV Sonne in October 2015 near the equator east of the Galapagos Islands and off the shelf of Peru, are used to investigate changes related to El Niño in the upper ocean in comparison with earlier cruises in this 10 region. At the equator at 85°30’W, a clear temperature increase leading to lower densities in the upper 350 m, despite a concurrent salinity increase from 40 to 350 m, developed in October 2015. Lower nutrient concentrations were also present in the upper 200 m, and higher oxygen concentrations were observed between 40 and 130 m. Except for the upper 60 m at 2°30’S, however, there was no obvious increase in oxygen concentrations at sampling stations just north (1°N) and south (2°30’S) of the 15 equator at 85°30’W. In the equatorial current field, the Equatorial Undercurrent (EUC) east of the Galapagos Islands almost disappeared in October 2015, with a transport of only 0.02 Sv in the equatorial channel between 1°S and 1°N, and a weak current band of 0.78 Sv located between 1°S and 2°30’S. Such near-disappearances of the EUC in the eastern Pacific seem to occur only during strong El Niño events. Off the Peruvian shelf at ~9°S, where the sea surface temperature (SST) was elevated, 20 upwelling was modified, and warm, saline and oxygen rich water was upwelled. Despite some weak El Niño related SST increase at ~12 to 16°S, the upwelling of cold, low salinity and oxygen-poor water was still active at the easternmost stations at three sections at ~12°S, ~14°S and ~16°S, while further west on these sections a transition to El Niño conditions appeared. Although in early 2015 the El Niño was strong and in October 2015 showed a clear El Niño influence on the EUC, in the eastern tropical 25 Pacific the measurements only showed developing El Niño water mass distributions. In particular the Ocean Sci. Discuss. , doi:10.5194/os-2016-14, 2016 Manuscript under review for journal Ocean Sci. Published: 24 March 2016 c © Author(s) 2016. CC-BY 3.0 License.
Comment on: “Exhumation of subcontinental mantle rocks: evidence from ultramafic-bearing clastic deposits nearby the Lherz peridotite body, French Pyrenees” by C. Clerc et al. (Bull. Soc. géol. Fr., 2012, 183, 5, 443–459)

In their recently published paper, C. Clerc et al . [2012] describe the geological setting of the Etang de Lherz peridotite body and give a short review of the associated clastic deposits, proposing a detailed analysis of the breccias cropping out in a limited area east of the lherzolite massif. The cartographic, sedimentological and metamorphic evidence leads the authors to regard these breccias as a shallow marine to lacustrine equivalent of the Albo-Cenomanian “Flysch noir” of the Pyrenees. This interpretation backs up their previous attribution of the breccias to a thick submarine clastic formation, of Albo-Cenomanian age, which incorporates olistoliths derived from the famous Etang de Lherz lherzolite and its neighbouring bodies. Clerc et al. firstly present a somewhat theoretical discussion concerning a 3D reconstruction of the depositional environment of the Lherz breccias, along with a possible scenario for their origin and structural history, which then leads onto three possible scenarios for North-Pyrenean rifting. The authors use this approach to support their previous conclusions, i.e.: the heterometric peridotite fragments contained in the Lherz breccias (from sand-sized debris up to olistoliths) provide clear evidence for an Albo-Cenomanian subaqueous exhumation of the subcontinental mantle at the borders or on the floor of the North-Pyrenean Aulus basin. Our comment focuses on a number of geological details concerning the Lherz breccias and their local or regional context, which the authors fail to take into account, either in their present paper or in earlier studies. Indeed, these details are of crucial interest since they call into question the assumption of a sedimentary origin for the Lherz breccias and, consequently, the exhumation of mantle in the Aulus basin. This map covers an area of 100×200 m located on the western side of the middle part of the so called “Ravin de Paumeres” [or “Ravin de l’Homme-mort” …