Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulatory Properties of Vitamin D in Type 2 Diabetic Patients: A Focus on Inflammation and Dyslipidemia

Background: Evidence from preclinical studies has found a correlation between the development of type 2 diabetes (T2D) and vitamin D deficiency. However, evidence from randomized controlled trials (RCTs) revealed inconclusive results on vitamin D supplementation. We explored the effect of vitamin D on inflammation and dyslipidemia in T2D. Methods: We comprehensively searched for RCTs evaluating the effect of vitamin D in T2D on PubMed. Data were analyzed using Review Manager 5.3 and reports, such as standardized mean difference (SMD) and 95% confidence intervals (CI) at a 5% significant level using a random effect model. Results: This study revealed a significant reduction in tumor necrosis factor-alpha (TNF-α) SMD = (−0.51, 95%CI (−0.93, −0.09); p = 0.02), high sensitivity C-reactive protein (hs-CRP) SMD = (−1.06, 95%CI (−1.67, −0.45); p < 0.05) in vitamin D compared to placebo. Additionally, interleukin-6 (IL-6) exhibited a marginal effect SMD = (−0.52, 95%CI (−1.05, 0.01), p = 0.05). Furthermore, a significant reduction in the level of triglycerides SMD = (−0.65, 95%CI (−1.11, −0.18), p < 0.05) was observed, concomitant to a significantly increased high-density lipoprotein (HDL) level SMD = (0.53, 95%CI (0.08, 0.98), p = 0.02). However, no statistically significant changes were observed in total cholesterols SMD = (−0.16, 95%CI (−0.57, 0.24), p = 0.43) and low-density lipoprotein (LDL) SMD = (−0.06, 95%CI (−0.37, 0.24), p = 0.67). Conclusions: These findings suggest that vitamin D supplementation may be beneficial in ameliorating inflammation and dyslipidemia in T2D patients.
Case Report: The impact of severe cryptosporidiosis on the gut microbiota of a pediatric patient with CD40L immunodeficiency

Cryptosporidium parvum is a protozoan parasite and one of the leading causes of gastroenteritis in the world, primarily affecting very young children and immunocompromised patients. While infection is usually self-limiting, it can become chronic and even lethal in these vulnerable populations, in whom Cryptosporidium treatments are generally ineffective, due to their acting in concert with a functioning immune system. Here, we describe a case of chronic cryptosporidiosis in a European child with severe CD40L immunodeficiency infected with Cryptosporidium parvum of the IIa20G1 subgenotype, a lineage which has thus far only ever been described in the Middle East. After years of on-off treatment with conventional and non-conventional anti-parasitic drugs failed to clear parasitosis, we performed targeted metagenomics to observe the bacterial composition of the patient’s gut microbiota (GM), and to evaluate fecal microbiota transplantation (FMT) as a potential treatment option. We found that C. parvum infection led to significant shifts in GM bacterial composition in our patient, with consequent shifts in predicted intestinal functional signatures consistent with a state of persistent inflammation. This, combined with the patient’s poor prognosis and increasing parasitic burden despite many rounds of anti-parasitic drug treatments, made the patient a potential candidate for an experimental FMT procedure. Unfortunately, given the many comorbidities that were precipitated by the patient’s immunodeficiency and chronic C. parvum infection, FMT was postponed in favor of more urgently necessary liver and bone marrow transplants. Tragically, after the first liver transplant failed, the patient lost his life before undergoing FMT and a second liver transplant. With this case report, we present the first description of how cryptosporidiosis can shape the gut microbiota of a pediatric patient with severe immunodeficiency. Finally, we discuss how both our results and the current scientific literature suggest that GM modulations, either by probiotics or FMT, can become novel treatment options for chronic Cryptosporidium infection and its consequent complications, especially in those patients who do not respond to the currently available anti-parasitic therapies.
A Semi-Strong Form Test of Emerging Market Efficiency: Evidence to An African Stock Market

: Based on the semi-strong form tests of an Efficient Market Hypothesis (EMH) a market that adjusts rapidly to new information, this paper contributes to the existing literature by examining the way stock markets react to political news. Using the event study methodology, we assess the speed of stock price adjustment to nine political events that occurred in the West African Economic and Monetary Union (WAEMU) from 1999 to 2020 for a sample of 25 firms listed on this regional African Stock Market (ASM). News related to political events are analyzed because of their impact on stock prices. The abnormal returns are determined by using the multivariate regression model of Binder (1985) associated with EGARCH (1.1) modeling to reflect the asymmetric specification of events and changes in volatility over time. The graphical representation and statistical analysis of Average Abnormal Return (AAR), document the existence of Average Abnormal Return statistically significant and abnormal price reactions before the public announcement of political events. In economic terms, this might indicate that market agents receive or anticipate the information even before their effective disclosure to the public. Besides, the speed of stock price adjustment to political events is slow. These results are not consistent with EMH in its semi-strong form. In general, these findings estimate the scale of market reaction and its speed in an emerging market such as WAEMU Stock Exchange through its significant effects on asset pricing. Finally, these findings reinforce the role of political risk on financial markets in emerging economies and allow economic agents to outline strategies to predict stock return behavior during periods of political turmoil.
Allocortex and Isocortex in Healthy Children Localized Proton MR Spectroscopy of the

BACKGROUND AND PURPOSE: The human allocortex is different from the isocortex in neuroglial cytoarchitecture. The purpose of this study was to compare metabolic data of the allocortex with those of the isocortex by using localized proton MR spectroscopy. METHODS: Short-TE stimulated-echo acquisition mode proton MR spectroscopy (TR/TE (cid:53) 3000/30) was applied to the allocortex of the temporal lobe and isocortex of the parietal or frontal lobe in 30 healthy children (19 boys and 11 girls, 3–14 years old). Peak intensities of N -acetylaspartate (NAA), choline-containing compounds (Cho), and myo -inositol (mI) relative to creatine and phosphocreatine (Cr) were calculated. Metabolic data from the investigated regions were compared. RESULTS: NAA/Cr was signiﬁcantly lower in the allocortex than in the isocortex of the parietal or frontal lobe: 1.05 (cid:54) 0.12 (n (cid:53) 33) vs. 1.36 (cid:54) 0.10 (n (cid:53) 28) or 1.32 (cid:54) 0.10 (n (cid:53) 12), respectively. Cho/Cr and mI/Cr were signiﬁcantly higher in the allocortex than in the isocortex: 0.84 (cid:54) 0.11 vs. 0.56 (cid:54) 0.06 or 0.75 (cid:54) 0.10; 0.78 (cid:54) 0.15 vs. 0.54 (cid:54) 0.08 or 0.66 (cid:54) 0.09, respectively. In the isocortex, NAA/Cr was not different but Cho/Cr and mI/Cr were signiﬁcantly
Do perceived value and satisfaction affect customers’ behavioural intentions? A case study of Polish squash clubs

The aim of the paper is to analyze relations between perceived quality, service convenience and satisfaction of squash customers to present implications for managers who address parents enrolling their children for extracurricular activities with their services. Applying the research framework of García-Fernández et al. (2018), a sample of 120 parents from Legia Warszawa Squash Academy completed an online survey in 2021. The SEM model revealed that perceived quality as well as service convenience had a positive and significant effect on perceived value, which turned out to be a strong predictor of customer satisfaction. Finally, satisfaction showed a very strong positive and significant influence on behavioral intentions of squash customers. The present study makes both a theoretical and a practical contribution to the field of sports management, highlighting the importance of perceived quality and service convenience to deliver expected value to the customer.
THE INFLUENCE OF WOMEN GROUPS ON INCOME AND GENDER RELATIONS IN DAIRY FARMING: CASE OF ARUMERU DISTRICT

A study on the influence of women groups on income and gender relations in dairy farming was carried in Arumeru district. The study aimed at determining sources of household income, differences in income from dairy production between women in groups and those not in groups and to investigate gender relations in management of dairy production. The study was conducted in six villages namely Bangata, Sasi, Inshupu, Enaboishu, Sokoni II and Nkoaranga whereby both women in dairy farming groups and those not in groups were surveyed. Cross sectional research design was adopted using structured questionnaires to collect information from households. Furthermore, an in depth interview with key informants was done to gather more information on dairy farming. Statistical Package for Social Sciencies (SPSS) was used for data analysis. Chi-square and t-test were used to test the statistical significance of categorical and continuous data respectively. In addition, regression model was used to investigate the effect of group membership in determining income from dairy farming. Results from the study showed that revenues from dairy products such as fresh milk, sour milk and butter brought more income than other sources. It was also found that group membership was not a determinant of income from dairy farming though women in groups had access to several benefits such as access to loans, training, provision of dairy cattle etc. It was also observed that being in groups assisted women to overcome traditional men dominance which blocked their rights in decision making and owning resources. To improve performance of women’s group in dairy farming, it was recommended that, women groups should get more financial assistance from the government, local NGO’s and donors. In conjunction with encouraging more women to join groups, gender relations in dairy management should be reassessed to minimize the work load burden to women, which affects the level of production. ii
AWARENESS TOWARDS CHILD ABUSE AMONG DENTAL STUDENTS AND THEIR POSSIBLE ROLE IN ITS MANAGEMENT: A KAP STUDY

Introduction: Dentistry has a lot to offer to law enforcement agencies and the society in the detection and solution of the crime against child. Oral cavity inspections give enough clue to rule out any mistreatment. It is therefore the need of the hour for upcoming dental practitioners to possess sound knowledge about child abuse and its judicial applications. Aims and Objectives : The present study was undertaken to analyse and assess the awareness of child abuse among budding practitioners. Materials and Methods : A cross-sectional study was conducted among 250 dental students of Babu Banarasi Das College of Dental Sciences. Data was collected via a google questionnaire. Result: The overall result revealed inadequate knowledge and awareness regarding signs and symptoms of Child abuse and neglect (CAN), among the budding dental surgeons.
NeuroInterventional Surgery Radiology, and the Society of Neuroradiology, the American College of Joint Statement by the American Society of and Transient Ischemic Attack Patients: A Imaging Recommendations for Acute Stroke

SUMMARY: Stroke is a leading cause of death and disability worldwide. Imaging plays a critical role in evaluating patients suspected of acute stroke and transient ischemic attack, especially before initiating treatment. Over the past few decades, major advances have occurred in stroke imaging and treatment, including Food and Drug Administration approval of recanalization therapies for the treatment of acute ischemic stroke. A wide variety of imaging techniques has become available to assess vascular lesions and brain tissue status in acute stroke patients. However, the practical challenge for physicians is to understand the multiple facets of these imaging techniques, including which imaging techniques to implement and how to optimally use them, given available resources at their local institution. Important considerations include constraints of time, cost, access to imaging modalities, preferences of treating physicians, availability of expertise, and availability of endovascular therapy. The choice of which imaging techniques to employ is impacted by both the time urgency for evaluation of patients and the complexity of the literature on acute stroke imaging. Ideally, imaging algorithms should incorporate techniques that provide optimal beneﬁt for improved patient outcomes without delaying treatment.
The Implementation of an Intensive English Language Program in the Fifth Grade in Turkey: A Qualitative Evaluation

: This qualitative evaluation study aims to investigate the implementation process of a current educational reform on teaching English to young learners in Turkey, the Intensive English Language Program in the Fifth Grade, from English as a foreign language (EFL) teachers’ viewpoints. Seven EFL teachers at pilot schools in the city-center of Erzincan were interviewed twice. The results of the first round of interviews indicated that despite the challenges arising from the pilot program, the teachers had positive attitudes regarding the potential advantages of the program. However, the final interview results painted a different picture in that although the main principles of the policy were seen as beneficial for young learners, the teachers faced a variety of challenges, such as a heavy compulsory curriculum in terms of content, lack of professional development support on the new program and scarcity of suitable language teaching materials. Based on both these problems and the benefits of the program, the teachers offered several suggestions for improving the quality of the program; these targeted elements including poor design of the program and unsatisfying professional development support. This study takes a snapshot of the implementation of the current EFL reform and presents suggestions for policymakers and teachers.
in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study

Objective —White matter lesions are often seen on MR scans of elderly non-demented and demented people. They are attributed to degenerative changes of small vessels and are implicated in the pathogenesis of cognitive decline and dementia. There is evidence that especially periventricular white matter lesions are related to cognitive decline, whereas subcortical white matter lesions may be related to late onset depression. The frequency distribution of subcortical and periventricular white matter lesions according to age and sex reported. Methods —A total of 1077 subjects aged between 60–90 years were randomly sampled from the general population. All subjects underwent 1.5T MR scanning; white matter lesions were rated separately for the subcortical region and the periventricular region. Results —Of all subjects 8% were completely free of subcortical white matter lesions, 20% had no periventricular white matter lesions, and 5% had no white matter lesions in either of these locations. The proportion with white matter lesions increased with age, similarly for men and women. Women tended to have more sub-cortical white matter lesions than men (total volume 1.45 ml v 1.29 ml; p=0.33), mainly caused by marked di V erences in the frontal white matter lesion volume (0.89 ml v 0.70 ml; p=0.08). Periventricular white matter lesions were also more frequent among women than men (mean grade 2.5 v 2.3; p=0.07). Also severe degrees of subcortical white matter lesions were more common in women than in men (OR 1.1; 95% conﬁdence interval (95% CI) 0.8–1.5) and periventricular white matter lesions (OR 1.2; 95% CI 0.9– 1.7), albeit that none of these ﬁndings were statistically signiﬁcant. Conclusions —The prevalence and the degree of cerebral white matter lesions increased with age. Women tended to have a higher degree of white matter lesions than men. This may underlie the ﬁnding of a higher incidence of dementia in women than in men, particularly at later age.
Testing crevasse-depth models: a field study at Breiðamerkurjökull, Iceland

Abstract Interest in crevasses and associated ice-fracture processes has recently increased due to recognition of the importance of calving glaciers to the mass balance of the cryosphere, as well as the importance of fractures in glacier hydrology. Recently developed calving criteria make use of models which predict crevasse depth from surface strain rates, but these models have rarely been tested against observations. In this study, we present data on crevasse depth and surface strain rates, and compare the measured values with results of two crevasse-depth models: a simple function proposed by Nye and a linear elastic fracture mechanics (LEFM) model developed by Van der Veen. Our results indicate that both models predict crevasse depths within the correct order of magnitude. The LEFM model, incorporating measured values of crevasse spacing and tuned for fracture toughness, performs better in predicting crevasse depths, but where lack of input data precludes such tuning, the results are similar to Nye’s model predictions. We conclude that both models may be used to calculate crevasse depths in calving models, although the Nye function is undoubtedly much simpler to implement within an ice-dynamics model.
SEASONALITY OF FISHES OCCUPYING A SURF ZONE HABITAT IN THE NORTHERN GULF OF MEXICO

ABSTRACf The ichthyafauna occupying the surf ~one habitat of Hom Island, Mississippi. between 19i5 and 1977 was dominated by immature dupeiform fishes. The dusky ancho\'y, Anchoo l),olO! pis, and the scaled sardine, Harengu/ajaguono, together constituted SO.N ofthe 154,469 fishes collect.ed. The greatest number of fishes were collected in the latc spring and summer, followed by a secondary peak in late winter. Occurrence of the fishes within the surf zone is divided into three categories according to seasonal utili~tion: spring and summer, summer only, and winter. Factors affecting numerical abun· dance within the surhone differed among the most frequently appearing species. Differences in the numbers of dupeiform fishes- A. lyolepis; A. Mp~tus, striped anchovy; and H . jagUllna - were more dosely associated with diel changes including tidal stage and time of day. Theabundance of the Florida pompano, 7hzchinotus caroJinus, and the gulf kingfish, Mrnlicirmus /itlorolis, were more dependent upon seasonal effects such as temperature. Relatively few studies have investigated the role of exposed surf zone habitats in the early life history of fishes, While Springer and Woodburn (1960) de­ scribed thesurfzone region as an "extreme habitat offering little environmental diversity," this habitat does provide several benefits to fishes. Ad­ vantages suggested by Warfel and Merriman (1944) included the abundance of food (concen­ trated by incoming tides), increased metabolic efficiency via heat acquisition, and protection from predation. Surf zone ichthyofaunas are numerically domi· nated by relatively few species. For instance, McFarland (1963) stated that 60-80% of the ich· thyofauna occupying the surf regions along the south Atlantic and Texas coasts was comprised of only a few species. Gunter (1958) found high simi· larity in species composition between Mustang Is· land, Texas, and Atlantic coast surf zones and suggested that the surfzone region was dominated by a small group of species which remained rela· tively constant over wide geographical areas. Much of the literature regarding shore zone fishes is restricted to either descriptions of species occurrence or seasonal characterizations. seldom exceeding one annual cycle. Reid (1955a, b), Schaefer (1967), and Hillman et a1. (1977) have
Impact Of Emotional Intelligence On Personality Domains And Career Search Self-Efficacy Among Ph.D. Scholars

This research investigates the impact of emotional intelligence (EI) on personality domains and career search self-efficacy (CSE) among PhD Scholars. The objectives of this study are to determine the direct and indirect relationships between EI and the examined psychological constructs and to identify EI's mediating effects in these relationships. The research methodology employed is a quantitative study with a convenience sample of PhD scholars from different Pakistani universities. The study's results showed that EI positively correlated with CSE and neuroticism, extraversion, agreeableness and conscientiousness. Furthermore, EI was a significant mediator between personality and CSE
A Method for Fabricating Flexible Transparent Free-Form Displays

TransPrint is a method for fabricating flexible, transparent free-form displays based on electrochromism. Using screen-printing or inkjet printing of electrochromic ink, plus a straightforward assembly process, TransPrint enables rapid prototyping of displays by nonexperts. The displays are nonlight-emissive and only require power to switch state and support the integration of capacitive touch sensing for interactivity. We present instructions and best practices on how to design and assemble the displays and discuss the benefits and shortcomings of the TransPrint approach. To demonstrate the broad applicability of the approach, we present six application prototypes.
Gene expression profiles and protein–protein interaction network analysis in AIDS patients with HIV-associated encephalitis and dementia

: Central nervous system dysfunction is an important cause of morbidity and mortality in patients with human immunodeficiency virus type 1 (HIV-1) infection and acquired immunodeficiency virus syndrome (AIDS). Patients with AIDS are usually affected by HIV-associated encephalitis (HIVE) with viral replication limited to cells of monocyte origin. To examine the molecular mechanisms underlying HIVE-induced dementia, the GSE4755 Affymetrix data were obtained from the Gene Expression Omnibus database and the differentially expressed genes (DEGs) between the samples from AIDS patients with and without apparent features of HIVE-induced dementia were identified. In addition, protein–protein interaction networks were constructed by mapping DEGs into protein–protein interaction data to identify the pathways that these DEGs are involved in. The results revealed that the expression of 1,528 DEGs is mainly involved in the immune response, regulation of cell proliferation, cellular response to inflammation, signal transduction, and viral replication cycle. Heat-shock protein alpha, class A member 1 (HSP90AA1), and fibronectin 1 were detected as hub nodes with degree values . 130. In conclusion, the results indicate that HSP90A and fibronectin 1 play important roles in HIVE pathogenesis.
Reliable $H_\infty$ Control for Discrete-Time Fuzzy Systems With Infinite-Distributed Delay

In this paper, the problem of reliable H∞ control is investigated for discrete-time Takagi-Sugeno (T-S) fuzzy systems with infinite-distributed delay and actuator faults. A discrete-time homogeneous Markov chain is used to represent the stochastic behavior of actuator faults. In terms of a stochastic fuzzy Lyapunov functional, a sufficient condition is proposed to ensure that the resultant closed-loop system is exponentially stable in the mean-square sense with an H∞ performance index. Based on the derived condition, the reliable H∞ control problem is solved, and an explicit expression of the desired controller is also given. The case of no failure in the actuator is also considered. A numerical example is given to demonstrate that our results are effective and less conservative.