Miracle-dz/UniFAR-FTUs huggingface dataset:
“Splitting the bill” for conservation: Perceptions and uptake of financial incentives by landholders managing privately protected areas

Globally, privately protected area (PPA) programs are increasing in size and number. Participating in a PPA program can be fiscally challenging for landholders (e.g., enrollment costs; potential reduction in land value; opportunity costs; costs of ongoing management). Government and nongovernmental organizations often offer financial incentives to landholders, in addition to nonfinancial incentives, to encourage program enrollment and ongoing biodiversity management. In Australia, where conservation covenanting programs have been ongoing for several decades, a diversity of financial incentives is available to landholders. We surveyed 527 conservation covenantors from three states in southeast Australia to investigate the uptake, use, experience and preference for financial incentives. Less than half of covenantors received a financial incentive to enroll, but most applied for some form of incentive after enrollment, predominantly to help with management costs. Covenantors identified challenges in accessing incentives, such as being unaware of funding opportunities or experiencing confusing application processes. We found land rates rebates to be the preferred financial incentive among covenantors, in part due to the perception that covenantors should not have to pay full rates on covenanted land. Our results suggest that while covenantors do not participate in PPA programs for financial incentives, effectively and efficiently deploying financial incentives can reduce the financial burdens of PPA management, potentially increasing the effectiveness of conservation efforts.
Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Cancer remains one of the leading causes of death in the world. For a number of neoplasms, the efficiency of conventional chemo- and radiation therapies is insufficient because of drug resistance and marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored in tumor treatment. However, despite attractive promises, the current PPT status is limited by laboratory experiments, academic papers, and only a few preclinical studies. Unfortunately, most nanoformulations still share a similar fate: great laboratory promises and fair preclinical trials. This review discusses the current challenges and prospects of plasmonic nanomedicine based on PPT and photodynamic therapy (PDT). We start with consideration of the fundamental principles underlying plasmonic properties of AuNPs to tune their plasmon resonance for the desired NIR-I, NIR-2, and SWIR optical windows. The basic principles for simulation of optical cross-sections and plasmonic heating under CW and pulsed irradiation are discussed. Then, we consider the state-of-the-art methods for wet chemical synthesis of the most popular PPPT AuNPs such as silica/gold nanoshells, Au nanostars, nanorods, and nanocages. The photothermal efficiencies of these nanoparticles are compared, and their applications to current nanomedicine are shortly discussed. In a separate section, we discuss the fabrication of gold and other nanoparticles by the pulsed laser ablation in liquid method. The second part of the review is devoted to our recent experimental results on laser-activated interaction of AuNPs with tumor and healthy tissues and current achievements of other research groups in this application area. The unresolved issues of PPT are the significant accumulation of AuNPs in the organs of the mononuclear phagocyte system, causing potential toxic effects of nanoparticles, and the possibility of tumor recurrence due to the presence of survived tumor cells. The prospective ways of solving these problems are discussed, including developing combined antitumor therapy based on combined PPT and PDT. In the conclusion section, we summarize the most urgent needs of current PPT-based nanomedicine.
Prognostic Significance of Admission Glucose Combined with Hemoglobin A1c in Acute Ischemic Stroke Patients with Reperfusion Therapy

Background: Elevated admission glucose and hemoglobin A1c (HbA1c) levels have been suggested to be associated with 90-day functional outcomes in acute ischemic stroke (AIS) patients with endovascular thrombectomy (EVT). However, whether the prognostic significance of admission glucose and that of HbA1c have a joint effect on patients with intravascular thrombolysis (IVT) and/or EVT remains unclear. This study aimed to explore the association between admission glucose combined with HbA1c and outcomes in patients with reperfusion therapy. Methods: Consecutive AIS patients treated with IVT and/or EVT between 2 January 2018 and 27 February 2021 in West China hospital were enrolled. Admission glucose and HbA1c levels were measured at admission. Participants were divided into four groups according to admission glucose level (categorical variable: <7.8 and ≥7.8 mmol/L) and HbA1c level (categorical variable: <6.5% and ≥6.5%): normal glucose and normal HbA1c (NGNA), normal glucose and high HbA1c (NGHA), high glucose and normal HbA1c (HGNA), and high glucose and high HbA1c (HGHA). The primary outcome was an unfavorable functional outcome defined as a modified Rankin Scale (mRS) ≥ 3. The secondary outcome was all-cause mortality at 90 days. Results: A total of 519 patients (mean age, 69.0 ± 13.4 years; 53.8% males) were included. Patients in the HGHA group had a significantly increased risk of unfavorable functional outcome (OR, 1.81; 95%CI, 1.01–3.23) and mortality (OR, 1.75; 95%CI, 1.01–3.06) at 90 days compared with those in the NGNA group after adjustment for confounders. There was no significant association between NGHA (OR, 0.43; 95%CI, 0.12–1.53) or HGNA (OR, 1.46; 95%CI, 0.84–2.56) and outcomes compared to the NGNA group. Conclusion: The combination of high admission glucose and high HbA1c level was significantly associated with unfavorable functional outcome and mortality at 90 days in AIS patients with reperfusion therapy.
Fault Source Model and Stress Changes of the 2021 Mw 7.4 Maduo Earthquake, China, Constrained by InSAR and GPS Measurements

On 22 May 2021, an Mw 7.4 earthquake struck Maduo, China, within the eastern Bayan Har block of the Tibetan plateau. The eastward-extruding Bayan Har block is marked by active seismicity along its boundary faults, including the 2008 Mw 7.9 Wenchuan earthquake, but large earthquakes within the block are relatively rare. Thus, the Maduo earthquake could provide useful information about crustal deformation of the Tibetan plateau. Early reports, shortly after the earthquake, have suggested a sinistral strike-slip fault rupture, but the fault geometry and slip distribution vary in these models due to the limited observational constraints. Here, we reconstructed a model of fault geometry and coseismic slip using Interferometric Synthetic Aperture Radar and Global Positioning System data. A nonplanar fault model was constructed based on pixel-offset images and the optimized dip angle. The along-strike variation of the dip angle is small, so a single optimized dip is used. Our results suggest that the Maduo earthquake ruptured ∼156 km on a northwest-striking major fault that dips 78°, and ∼24 km on a minor southeast-striking fault that dips 64°. Most fault slip occurred above 15 km depth, and released a moment of ∼1.65×1020 N·m. Using the resolved fault source model, we calculated the change of coulomb failure stress in the region and on the neighboring faults. The Maduo earthquake highlighted intrablock deformation in the Tibetan plateau whereas numerous lithospheric blocks extrude along major strike-slip faults.
Pterostilbene attenuates the proliferation and differentiation of TNF-α-treated human periodontal ligament stem cells

Periodontitis is a common chronic inflammatory oral disease. The objective of periodontal treatment is to control infection whilst regenerating damaged periodontal tissue. The present study aimed to determine the potential effects of pterostilbene (PTE), a representative stilbene compound, on the proliferation and differentiation of human periodontal ligament stem cells (hPDLSCs). Different concentrations (1, 5, 10 and 20 µM) of PTE were applied to hPDLSCs, after which Cell Counting Kit-8 and western blotting assays were performed to examine the protein levels of Ki67, PCNA, p-IκBα, IκBα, Bcl-2, Bax, cleaved caspase3. The effect of PTE on the release of inflammatory factors, including IL-1β, IL-6 and IL-10 was assessed by RT-qPCR. The apoptosis of TNF-α-induced hPDLSCs was evaluated by TUNEL assay and western blotting. Additionally, the role of PTE in hPDLSC mineralization was evaluated using alizarin red staining. The expression levels of mineralization indices, including RUNX2 and ALP were subsequently determined using western blotting. Subsequently, the target of PTE was predicted using TargetNet database and AutoDock v4.2 software and verified using western blotting. The results of the present study revealed that PTE promoted the proliferation of hPDLSCs in a concentration-dependent manner. Furthermore, PTE treatment decreased the release of inflammatory factors and alleviated the apoptosis of TNF-α-induced hPDLSCs. PTE was also demonstrated to promote the formation of mineral nodules in TNF-α-induced hPDLSCs. The Targetnet database, along with molecular docking, indicated that histone deacetylases (HDACs) were the probable targets of PTE upstream of regulating periodontitis. The results of western blotting implied that TNF-α significantly increased expression levels of HDAC2, 4, 6 and 8, whilst PTE treatment markedly decreased HDAC4, 6 and 8 expression in a concentration-dependent manner compared with the TNF-α group, which further confirmed these conclusions. In summary, results of the present study revealed that PTE promoted TNF-α-induced hPDLSC proliferation and differentiation, whilst alleviating inflammation and apoptosis. PTE also inhibited the expression of HDACs, which may be involved in the mechanism of periodontitis.
How to Educate the Public about Dental Trauma—A Scoping Review

Educating the general population about dental trauma is of public health interest. The aim of this scoping review was to map research on traumatic dental injuries (TDIs) education in the general population and to identify the most relevant methods of knowledge transfer. PubMed, Scopus, Web of Science All Databases, reference lists, and grey literature were searched. Articles in English published between 2000 and 2020 were included. A total of 32 articles fulfilled inclusion criteria. The most frequently tested modality was lecture/seminar/workshop. Studies focused mainly on teachers and medical staff as target groups. Post-intervention evaluation showed an increase in knowledge. In long-term follow-up, a decrease in knowledge was found. The effectiveness of different modalities varied. Studies comparing single-modal and multimodal approaches did not confirm the effect of combined methods. Printed materials are a practical mode for laypeople. Lectures should be reserved for professions with high probability of coming into contact with a TDI victim. The Internet can be a promising tool to educate people. Educators have to choose the method of communication most appropriate for the target population. The education should include topics related to dental trauma prevention. Further research is needed to investigate the effectiveness of multimodal TDI education.
The Association between Postpartum Practice and Chinese Postpartum Depression: Identification of a Postpartum Depression-Related Dietary Pattern

Conflicting results of Chinese traditional postpartum practices have aroused concerns over their health effects. The role of postpartum practices in postpartum depression (PPD) is still a matter of discussion, especially from a dietary practice point of view. The current study was designed to (1) explore the association between postpartum practices and PPD, (2) to identify the dietary pattern related to PPD, and (3) to identify the possible pathways among postpartum practices and PPD. This study is part of the YI Study, which was a cross-sectional study conducted in 10 cities in China. Data for 955 postpartum women were used in the current analysis. The Edinburgh Postnatal Depression Scale (EPDS-10) was used to evaluate PPD with a cutoff value of 9. Postpartum practice was based on the participants’ self-reported practices. Individual practices were recorded and categorized as dietary and non-dietary practices. The dietary pattern was identified based on the food intake frequencies of 25 food groups using the method of reduced rank regression. Structural equation modeling was used to explore the potential pathways between postpartum practices and PPD. The current study observed significant associations between postpartum practices and PPD (Adjusted OR = 1.41, 95% CI: 1.04–1.90). A similar trend was also found between dietary postpartum practices and PPD (Adjusted OR = 1.39, 95%CI: 1.03–1.88) but not for non-dietary practices and PPD (Adjusted OR = 1.26, 95%CI: 0.92–1.75). A PPD-related dietary pattern was identified with the characteristics of a high intake of meat and eggs and a lower intake of vegetables, mushrooms, and nuts. This dietary pattern was significantly associated with a higher chance of adhering to postpartum practice (Adjusted OR = 1.26, 95% CI: 1.10–1.44). Based on the pathway analysis, this study also observed the association between postpartum practices and PPD, and the association between dietary practices and PPD were both mediated by sleep quality. In conclusion, this study demonstrated that a substantial proportion of women in modern China experience traditional postpartum Chinese practices and that either overall or dietary-related postpartum practices are associated with a higher risk of PPD. The current dietary practices in postpartum rituals may play an important role in developing PPD. A culturally embedded, science-based dietary guideline is required to help women to achieve both physical and psychological health in the postpartum period.
Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application

We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine whether a pharmacokinetic (PK)/pharmacodynamic (PD) relationship was present. The population PK of HCQ was described using non-linear mixed effects modelling. The duration of hospitalization, the number of deaths, and poor clinical outcomes (death, transfer to ICU, or hospitalization ≥ 10 d) were evaluated as PD parameters. From 100 hospitalized patients (age = 60.7 ± 16 y), 333 BHCQ and M were available for analysis. The data for BHCQ were best described by a four-compartment model with a first-order input (KA) and a first-order output. For M, the better model of the data used one compartment for each metabolite with a first-order input from HCQ and a first-order output. The fraction of HCQ converted to the metabolites was 75%. A significant relationship was observed between the duration of hospitalization and BHCQ at 48 h (r2 = 0.12; p = 0.0052) or 72 h (r2 = 0.16; p = 0.0012). At 48 h or 72 h, 87% or 91% of patients vs. 63% or 62% had a duration < 25 d with a BHCQ higher or below 200 μg/L, respectively. Clinical outcome was significantly related to BHCQ at 48 h (good outcome 369 +/− 181 μg/L vs. poor 285 +/− 144 μg/L; p = 0.0441) but not at 72 h (407 +/− 207 μg/L vs. 311 +/− 174 μg/L; p = 0.0502). The number of deaths was not significantly different according to the trough concentration (p = 0.972 and 0.836 for 48 h and 72 h, respectively).
Imperative Patriotism and Minority Candidacies: Examining the Role of Military Status in Racial Evaluations of South Asian Candidates

South Asians have seen an increase in representation at all levels of US government, from Congress to the Vice Presidency, yet a paucity of work has been done examining South Asian candidates in America. The distinct nature of South Asian candidacies allows us to examine the intersection between race and religious identity and how emphasizing different social and political identities impact minority candidate evaluations. We theorize the potential effects of racial-political stereotyping of South Asians, focusing specifically on how a Hindu or Muslim background may negatively influence candidate evaluation. Additionally, we consider whether military service has any effect on evaluations of South Asian candidates as dangerous or deficient. We test this theory with a survey experiment that varies both South Asian religious identity, political ideology, and military service. Our findings indicate that white respondents are more hostile to South Asian candidates when compared to white candidates with similar biographies, and that respondents are particularly hostile to Muslim candidates. Cueing military service alleviates this handicap for Muslim candidates, but further analysis reveals that military service only improves perceptions among Democratic respondents.
Pengaruh likuiditas, profitabilitas dan leverage terhadap agresivitas pajak

Penelitian ini bertujuan untuk mengetahui pengaruh likuiditas, profitabilitas, dan leverage terhadap agresivitas pajak. Variabel independen yang digunakan meliputi likuiditas, profitabilitas, dan leverage sedangkan agresivitas pajak sebagai variabel dependen. Populasi yang digunakan dalam penelitian ini adalah laporan keuangan tahunan perusahaan manufaktur sub sektor food and beverage yang terdaftar di Bursa Efek Indonesia tahun 2011 – 2018 yang berjumlah 11 perusahaan. Teknik pengambilan sampel pada penelitian ini menggunakan metode purposive sampling (Penentuan sampel menggunakan kriteria tertentu) dan diperoleh sampel sebanyak 9 perusahaan manufaktur sub sektor food and beverage. Metode yang digunakan pada penelitian ini meliputi analisis statistik deskriptif, uji asumsi klasik, analisis regresi linier berganda. Hasil penelitian yang dilakukan menunjukkan bahwa diantara variabel likuiditas, profitabilitas, dan leverage yang berpengaruh terhadap agresivitas pajak adalah variabel likuiditas.
Peace Sociolinguistics: A Constructivist Grounded Theory of Pakistani English Newspapers

This paper is a qualitative sociolinguistic study that theorizes the place of English as an official/second language in Pakistan. The data are taken from six Pakistani English newspapers covering the Pak-EU discourse from 2002 to 2018. This investigation uses constructivist grounded theory methodology (an off-shoot of grounded theory methodology) to generate a theory that shedslight on the peace potential of English language as used in the selected data. It is subsumed under the parameters of peace sociolinguistics, a relatively new field within the broader discipline of sociolinguistics. Peace sociolinguistics acknowledges all languages to be carriers of human values and capable of bringing different peoples together. In the classic style of grounded theorymethodology, primacy is given to language and codes are developed in order to show how English language is used to portray a common reality between two world entities, Pakistan and the EU. This sociolinguistic constructivist grounded theory study is underpinned by social constructionism which takes the view that language does not just describe the world but actively constructsit, having real consequences. The socially constructed reality presented here is shared and contextual and takes the form of a rigorous theory called “a theory of peace sociolinguistics of the EU-Pak discourse in selected Pakistani English newspapers. '' This theoretical rendering demonstrates the viability of English to be used for peaceful purposes while challenging the current dual status ofEnglish as a colonial legacy and a necessary agent of globalization.
Feeding System Effects on Dairy Cow Rumen Function and Milk Production

Simple Summary In ruminants, diet has a significant effect on rumen function. Hence, this study was conducted to see if changing the normal grass-based diet of cows could change rumen function and milk production. Therefore, we compared three diets: Grass (cows grazing grass-only), Grass-Clover (cows grazing grass-white clover only) and cows fed a total mixed ration (TMR) diet indoors. We monitored the cows over the course of a full lactation cycle in a spring-calving system. In order to examine rumen function, some of the cows had a cannula placed in their rumen so that we could collect rumen contents samples. After we collected the samples and analysed the data we found that the type of diet the cows were offered did significantly affect milk production; milk yield and milk solids yield were generally highest on the TMR diet. When we looked at the rumen sample data we found that diet also affected rumen function; it altered the rumen volatile fatty acid (VFA), and ammonia and lactic acid profiles significantly but did not effect on rumen pH. Clover inclusion in the diet led to higher total rumen VFA and ammonia concentrations and higher milk urea nitrogen compared to the grass and TMR diets. We suggest this indicates a higher protein intake on that diet. Given these findings, we concluded that a clover-based diet could significantly alter rumen function, milk composition and milk yield in dairy cows. Abstract Good rumen function, which is largely influenced by the diet of the cow, is essential to optimise animal performance. This study, conducted over the course of a full lactation in a spring-calving milk production system, compared the rumen function and milk production of cows offered one of three dietary treatments: (1) Cows grazing grass-only swards receiving 250 kg nitrogen (N)/ha/year (Grass), (2) Cows grazing grass-white clover swards receiving 250 kg N/ha/year (Grass-Clover), and (3) Cows offered a total mixed ration diet and housed indoors (TMR). Treatment significantly affected milk production; milk yield and milk solids yield were generally highest on the TMR treatment. There was no effect of treatment on rumen pH. However, treatment significantly altered the rumen volatile fatty acid (VFA), and ammonia and lactic acid profiles. Clover inclusion in the sward led to higher (p < 0.05) total VFA and ammonia concentrations compared to the Grass and TMR treatments. The increased rumen ammonia concentration was associated with a significantly greater milk urea nitrogen (MUN) content in the milk from cows fed on Grass-Clover, indicating a greater excess of dietary protein in that treatment. It was concluded that a clover-based dairy cow feeding system could significantly alter rumen function, milk composition and milk yield.