Miracle-dz/UniFAR-FTUs huggingface dataset:
RNA-Seq Analysis of Testes from Mice Exposed to Neodymium Oxide

(1) Objective: Rare earth neodymium oxide (Nd2O3) is refined and used extensively around the world, and the occupational and environmental safety of rare piles of the earth has attracted considerable attention. Nd2O3 enters the human body through the respiratory system, reaches various organs through blood circulation, and accumulates to produce toxic effects. At present, little is known about the reproductive toxicity of Nd2O3. Non-coding RNAs participate in a variety of physiological activities and are very important for spermatogenesis. However, it is unknown whether they are involved in Nd2O3-induced reproductive toxicity. Therefore, we conducted a pathological analysis, sperm quality testing, and RNA-seq on the testicular tissue of mice exposed to Nd2O3 to find the key genes and regulatory pathways of male reproductive damage and explore the early biomarkers and mechanisms of reproductive damage caused by Nd2O3. (2) Methods: After exposure of mice to Nd2O3, we carried out a pathological analysis and RNA-seq analysis for miRNAs/lncRNAs/circRNAs/mRNAs on the testicular tissue of mice, and the total RNAs were used to investigate miRNA/lncRNA/circRNA/mRNA expression profiles by strand-specific RNA sequencing at the transcriptome level to help uncover RNA-related mechanisms in Nd2O3-induced toxicity. (3) Results: Nd2O3 damaged testis and sperm morphology, significantly decreased the number of sperm, and deformed the sperm head and tail. RNA-seq analysis showed that the expression level of mRNA/miRNA/circRNA/lncRNA in the testicular tissue of mice exposed to Nd2O3 is abnormal. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that the functional enrichment of differentially expressed genes (DEGs) and their target genes was closely related to the related pathway of spermatogenesis. Furthermore, some miRNAs/lncRNAs/circRNAs that were greatly upregulated or inducibly expressed, implying their potential value as candidate markers for Nd2O3-induced reproductive toxicity, help us to further investigate the mechanisms of key genes, key signaling pathways, and inter-gene regulation for Nd2O3-induced reproductive toxicity. (4) Conclusions: This study provides the first database of a Nd2O3-induced transcriptome. This information is useful for the development of biomarkers of Nd2O3-induced reproductive injury and promotes understanding of the reproductive toxicity mechanism of Nd2O3.
Patient-Reported Outcome Measures of Flapless Corticotomy with Low-Level Laser Therapy in En Masse Retraction of Upper Anterior Teeth: A Three-Arm Randomized Controlled Trial

(1) Background: This study aimed to compare patient-reported outcome measures when accelerating en masse retraction between the piezocision procedure and the subsequent application of low-level laser therapy (FC+LLLT), with the piezocision alone (FC), and in a control group. (2) Methods: A three-arm randomized controlled trial (RCT) was conducted involving 60 patients (41 females and 19 males) with Class II division I malocclusion. The en masse retraction was performed using NiTi closed coil springs attached to miniscrews. The LLLT was performed using an 808 nm Ga-Al-As diode laser. Patient responses regarding pain, discomfort, swelling, and chewing difficulties were reported at ten assessment points. (3) Results: The greatest pain levels were observed 24 h after the application of force during the first and third months of retraction. The mean pain, discomfort, swelling, and chewing difficulties were significantly smaller in the control group than in the FC and FC+LLLT groups. High satisfaction levels were reported in all three groups (p < 0.05). (4) Conclusions: The accelerated en masse retraction via piezocision, followed by a small course of LLLT, was accompanied by significantly fewer pain, discomfort, and chewing difficulties than the control group. LLLT is a valuable addition to piezocision, with an improved patient experience.
Monitoring Metastatic Colorectal Cancer Progression According to Reactive Oxygen Metabolite Derivative Levels

Simple Summary Oxidative stress has been implicated in the development, proliferation, and metastasis of colorectal cancer. In this study, we investigated whether the rate of change in reactive oxygen metabolite derivatives (d-ROM)—serum markers of oxidative stress—could predict treatment response in metastatic colorectal cancer. We enrolled 53 patients with metastatic colorectal cancer who were treated with 3 months of chemotherapy. We measured d-ROM levels before and after chemotherapy and examined the change in d-ROM levels for each anticancer treatment. Factors influencing the d-ROM ratio (post-treatment: pre-treatment levels) were examined using linear regression analysis. d-ROM levels decreased in patients showing a partial response and increased in those showing disease progression. An increasing d-ROM ratio was associated with disease progression. Our study indicates that d-ROM levels are useful markers of tumor progression and that the d-ROM ratio is useful for predicting treatment response in patients with metastatic colorectal cancer. Abstract Oxidative stress has been implicated in the development, proliferation, and metastasis of colorectal cancer, but few studies have considered how oxidative stress changes in relation to treatment response. In this study, we investigated whether the rate of change in reactive oxygen metabolite derivatives (d-ROM)—serum markers of oxidative stress—could predict treatment response in metastatic colorectal cancer. We enrolled 53 patients with metastatic colorectal cancer who were treated with 3 months of chemotherapy. We measured d-ROM levels and performed computed tomography before and after chemotherapy, and we examined the change in d-ROM levels for each anticancer treatment. Factors influencing the d-ROM ratio (post-treatment: pre-treatment levels) were examined using linear regression analysis. d-ROM levels decreased in patients showing a partial response (p < 0.001) and increased in those showing disease progression (p = 0.042). An increasing d-ROM ratio was associated with disease progression (regression coefficient: 0.416, 95% confidence interval: 0.279–0.555, p < 0.001). Our study indicates that d-ROM levels are useful markers of tumor progression and that the d-ROM ratio is useful for predicting treatment response in patients with metastatic colorectal cancer.
Research into the relationship between digital health literacy and healthy lifestyle behaviors: an intergenerational comparison

Introduction Digital health literacy wields a pivotal role in individuals’ health status in terms of seeking and choosing appropriate and accurate information, and useful services from a vast array of choices. This study is aimed at assessing the validity and reliability of the Turkish version of Digital Health Literacy Instrument (DHLI) and examining the relationship between DHL and the healthy lifestyle behaviors of participants from X, Y, and Z generations. Methods In this study, to conduct a cross-sectional web-based survey, an online self-report questionnaire was built, and a convenience sample with a snowball approach was used. The study was conducted among 1,274 respondents aged between 18 and 64 years. Data collection tools consisted of the Personal Information Form, Lifestyle Behavior Scale II (HLBS II), and DHLI. Cultural validation and psychometric testing of DHLI, exploratory factor analysis, confirmatory factor analysis, Cronbach’s alpha test, and bivariate and multivariate regression analysis were used for statistical analysis. Results In the study, the Turkish version of the DHLI tool consisting of six dimensions proved to be valid and reliable, and deemed appropriate for use across all age groups. The average digital health literacy of the respondents was sufficient, but the mean of healthy lifestyle behavior scores was moderate. There was a positive significant relationship between the total mean scores of DHLI and HLBS. Among the subdimensions of DHLI, while the highest mean scores were in DHLI Reliability, DHLI Privacy, and DHLI Search, DHLI Navigation and DHLI Relevance showed the lowest mean scores. DHLI Reliability, DHLI Relevance, and DHLI Adding Content were statistically significant predictors of health-related behaviors of the respondents. Conclusion The most important feature and novelty of this study is that, although the DHLI scale has been widely translated for use in many countries, it has been translated and adapted to Turkish for the first time herein. The study offers crucial evidence about Generation X, Y, and Z’s DHL level and its positive relationships with health-related behaviors. Therefore, the community and its partners should lead the way in empowering individuals to understand and use online information in an effective, secure, and health-promoting manner, along with governments.
Sentiment Analysis of Students’ Reviews on Online Courses: A Transfer Learning Method

It is critical for higher education institutions to work on improvement of their teaching and learning strategy by examining feedback of students. Sentiment analysis (also known as opinion mining or emotion AI) refers to the use of natural language processing (NLP) and text analysis to systematically identify, extract and quantify states and subjective information. Transfer learning (TL) could be a ponder in machine learning centering on putting away information picked up whereas understanding one issue and applying it to a diverse but related issue. In this paper, we present the results from applying BERT, a transfer learning method for one of text classification problems. The model aims to predict state positive, negative, or neutral of an online course from students’ reviews. This result will be compared with the contributions of authors Kastrati et al. (2020). The results which using BERT are quite good (Accuracy 88.93%), giving us more hope for future research.
Stratigraphy, Tectonics, and Basin Evolution in the Anza-Borrego Desert Region

The fossil record of past life is commonly preserved in ancient sediments and sedimentary rocks. Sediments accumulate in subsiding basins that contain different kinds of depositional environments such as rivers, lakes, deltas, and marine seaways. These environments are friendly to life, and often support assemblages of plants and animals. Through integrative studies of stratigraphy, sedimentology, and paleontology, we can reconstruct ancient life communities and the environments in which they lived. Plate tectonic forces determine where sedimentary basins form, how long and how fast sediments accumulate, and how they may later be faulted, uplifted, and eroded at the surface. Climate also affects basins and sediments; precipitation, wind, and temperature variation affect surface processes such as erosion and soil formation. In the Salton Trough region of southern California, styles, rates, and environments of basin formation have evolved through time in response to complex changes in driving tectonic forces, fault interactions, and climate change. Because of the rich history of geologic research in Anza-Borrego Desert State Park and adjacent areas, it is impossible to summarize all of the knowledge on this subject in a few pages. This chapter presents a brief overview of existing knowledge about the regional stratigraphy, tectonic evolution, and major sedimentary basins preserved in the Park, which have supported a great diversity of plants and animals during the past ~10 million years.
Disfluency attenuates the reception of pseudoprofound and postmodernist bullshit

Four studies explore the role of perceptual fluency in attenuating bullshit receptivity, or the tendency for individuals to rate otherwise meaningless statements as “profound”. Across four studies, we presented participants with a sample of pseudoprofound bullshit statements in either a fluent or disfluent font and found that overall, disfluency attenuated bullshit receptivity while also finding little evidence that this effect was moderated by cognitive thinking style. In all studies, we measured participants’ cognitive reflection, need for cognition, faith in intuition, and superstitious beliefs. Superstition strongly predicted bullshit receptivity regardless of fluency. Inconclusive results were found for the remaining scales. Potential links for the role of perceptual disfluency in promoting analytic thinking are discussed.
Newly discovered Late Cretaceous molluscan fossils and inferred K/T boundary in the Nemuro Group, eastern Hokkaido, northern Japan.

Pachydiscus flexuosus, Tetragonites popetensis, Spheonoceramus hetonaianus, and other molluscan fossils are newly discovered from the Senpohshi, Hamanaka and middle Akkeshi formations, Nemuro Group, eastern Hokkaido, Japan. They are stage index fossils of Lower Maastrichtian. According to calcareous nannofossil biostratigraphy suggesting that the upper Akkeshi Formation is Paleocene in age, the K/T boundary in the Nemuro Group is possibly intercalated between the middle and upper Akkeshi Formation.
GENOTYPE X ENVIRONMENT INTERACTION AND STABILITY ANALYSIS IN RABI SORGHUM

Sixty rabi sorghum genotypes were evaluated for thr ee years in a single location to examine the existence of genotype x environment (G x E) int eraction for grain yield and related traits. PVR 659 and RSV 1161 had unit regression coefficient indicating average response over varying environments. Siddheswar Local (32.0), Barshi Joot (36.7) and Yermala Local (30.8) had non- significant deviation from regression indi cating their stability over environments for panicle length. Highest seed yield was recorded wit h RSV 821 (1536.5 kg/ha) followed by RSV 1037 (1518.2 kg/ha), RSV 744 (1452.5 kg/ha), Chungi Maldandi (1445.6 kg/ha) and
Validation of QuikSCAT wind vectors by dropwindsonde data from Dropwindsonde Observations for Typhoon Surveillance Near the Taiwan Region (DOTSTAR)

[1] The accuracy of 10 m wind vectors derived from the QuikSCAT satellite near tropical cyclones is validated against soundings from 457 GPS dropwindsondes deployed by Dropwindsonde Observations for Typhoon Surveillance Near the Taiwan Region (DOTSTAR) during 2003–2007. To maximize the database, the surface to 40 m wind speed in the dropwindsondes is averaged and interpolated to the 10 m wind speed by linear regression. After removing rain-flagged data, the root-mean-square differences between QuikSCAT and dropwindsonde data were 2.6 m s−1 or 18% (wind speed) and 17° (wind direction) on the basis of 896 matching samples. Further analyses also indicate that the QuikSCAT data slightly underestimates the wind speed of medium-wind regime (between 10 and 17.2 m s−1) and possesses some clockwise directional bias in the high-wind regime (above 17.2 m s−1). In summary, this study suggests that the QuikSCAT wind vectors below tropical storm wind strength (17.2 m s−1) are accurate enough for forecasters to determine the critical wind radius of 34 knot wind, while a new error bound of the QuikSCAT wind estimate in high-wind regimes near tropical cyclones is suggested to be set at about 4 m s−1.
Interaction of Thiol Antioxidants with α,β-Unsaturated Ketone Moiety: Its Implication for Stability and Bioactivity of Curcuminoids

Many biological functions of curcumin have been reported. As certain bioactivities of curcumin are eliminated by antioxidants, reactive oxygen species generated by curcumin have been suggested as a relevant mechanism. In the present study, the effects of different types of antioxidants on the stability and bioactivities of curcumin were analyzed. High concentrations (>4 mM) of thiol antioxidants, including N-acetylcysteine (NAC), glutathione (GSH), and β-mercaptoethanol, accelerated the decomposition of curcumin and other curcuminoids; the submillimolar levels (<0.5 mM) of GSH and NAC rather improved their stability. Ascorbic acid or superoxide dismutase also stabilized curcumin, regardless of their concentration. The cellular levels and bioactivities of curcumin, including its cytotoxicity and the induction of heme oxygenase-1, were significantly reduced in the presence of 8 mM of GSH and NAC. The effects were enhanced in the presence of submillilmolar GSH and NAC, or non-thiol antioxidants. The present results indicate that antioxidants with a reduced thiol group could directly interact with the α,β-unsaturated carbonyl moiety of curcuminoids and modulate their stability and bioactivity.
Vegetative compatibility type diversity of Cryphonectria para- sitica populations in Bosnia-Herzegovina, Spain and France

Cryphonectria parasitica, the causal agent of the chestnut blight, has been responsible for con siderable damage in chestnut ecosystems in several European countries in the last three decades. Vegetative compatibility types (vc types) were characterized in three countries as a tool to assess C. parasitica diversity in Europe and because hypovirulence, caused by a hypovirus, spreads through anastomosis between compatible isolates. In Bosnia-Herzegovina, eastern Spain (Catalonia) and France several areas were investigated. Canker samples were removed from several sites, and vc types determined using the European vc type testers. Vc type diversity was assessed with the Shannon index. C. parasitica populations appeared clearly differentiated inside each country and among the countries. In Bosnia-Herzegovina, dominant vc types were EU-1, EU-2, EU-12 or EU-13, de pending upon the region. All the other vc types found there belonged to the first 31 EU vc types. In Spain the dominant vc type was EU-2, six isolates were distributed in vc types between EU-65 and EU-74, and one vc type was incompatible with all the European vc type testers. In eastern France, dominant vc types were EU-1 and EU-5, whereas in western France, dominant vc types were EU-33 or EU-72, and 15 vc types were incompatible with all the European vc type testers.
Is Handgrip Strength Associated With Parkinson’s Disease? Longitudinal Study of 71 702 Older Adults

Background To date, no study has longitudinally assessed the dose–response association between handgrip strength and incidence of Parkinson’s Disease (PD). Objectives to investigate the longitudinal association between handgrip strength and the development of PD within a representative European population of older adults. Methods Individuals aged 50 years and older from 27 European countries and Israel participated. We retrieved data from the Survey of Health, Ageing and Retirement in Europe waves 1, 2, 4, 5, 6, 7, and 8. Handgrip strength was measured using a hand dynamometer and participants reported whether they had a medical PD diagnosis. Time-varying exposure and covariates were modeled using both Cox regression and restricted cubic splines. Results A total of 71 702 participants (mean age 65.2 years) were followed over a median period of 5.0 years. Among them, 314 participants developed PD. In the fully adjusted model, we observed a higher risk (hazard ratio [HR]: 2.50; 95% CI:1.92-3.32) of PD for participants with lower handgrip strength (third 1) and a lower risk of PD for participants in the second third (HR: 1.41; 95% CI: 1.06-1.87). In dose–response analyses, men showed lower risk of PD from 27 kg (HR:0.94; 95% CI: 0.91-0.97) to 59 kg (HR:0.10; 95% CI: 0.04-0.22), whereas women showed significant reductions from 24 kg (HR:0.68; 95% CI: 0.46-0.99) to 38 kg (HR:0.44; 95% CI: 0.22-0.88). Conclusions Handgrip strength ought to be incorporated as one of the measures in the prognostic toolbox for the screening of older adults who are possibly at risk of developing PD.
Critical weed-crop competition period versus yield of sesame (Sesamum indicum L.) at Tikamgarh district of Madhya Pradesh

A field experiment was conducted during two consecutive kharif of 2009 and 2010 to estimate the critical period for weed control for sesame at Tikamgarh district of Madhya Pradesh. The treatments comprised of quantitative series of both increasing duration of weediness i.e., early (weedy up to 15, 30, 45, and 60 DAS) and weed free periods i.e., late (weed free up to 15, 30, 45, and 60 DAS) competition periods and were compared with complete weed free (CWF) and weedy check (WC). Weeds count gradually increased as the duration of weed-crop association increased up to 60 DAS. As period for weed-crop competition increased either in early and late competition situation, weed dry weight also increased. Similarly, weed control efficiency was also increased with an increase in weed free competition period. In early competition, the highest sesame seed yield of 775 kg/ha was recorded under weedy up to 15 DAS and about 59% higher sesame seed yield than WC and 18% yield loss compared to the CWF. In late competition, the highest seed yield of 856 kg/ha was obtained in weed free up to 60 DAS and resulted into 60% higher seed yield over WC and 15% yield loss than CWF. However, weed free up to 15, 30 and 45 DAS treatments were differed non-significantly among themselves for seed yield. In early competition, data clearly indicated that weedy up to 15, 30 and 45 DAS gave about 75%, 62% and 51% higher net return, respectively over WC treatment. Weed free up to 15, 30 and 45 DAS conferred about 73%, 75% and 75% higher net return, respectively over WC. The weedy up to 15 DAS, weed free up to 15 DAS, 30 DAS and 45 DAS exhibited the higher net return per rupee invested (B:C) as compared to other weed-crop competition periods. Weedy up to 15 DAS and weed free up to 30 and 45 DAS showed to reduce less than 15% to 18% sesame yield loss in margins. Similarly, difference in B:C among these treatments was also marginal i.e., <2.5% to 5.5%. Thus, the critical period for weed control for sesame at Tikamgarh district of Madhya Pradesh was found to be about 15 to 45 DAS.
Surface exposure dating (36Cl and 10Be) of post‐Last Glacial Maximum valley moraines, Lake District, northwest England: some issues and implications

Surface exposure ages (36Cl and 10Be) have been obtained from 16 boulders at the margins of and within the limits of former valley glaciers at four sites in the Lake District, northwest England. The established view is that the Lake District functioned as an independent centre of ice dispersal during the Last Glacial Maximum (LGM; 26–21 ka) of the Dimlington Stade (≈Greenland Stades 2–3) and that the glacial‐depositional landforms at the sampled sites are products of stillstands or readvances of the ice margins following the LGM. However, several of the apparent 36Cl surface exposure ages pre‐date rather than post‐date the LGM. It is inferred that these boulders retain levels of 36Cl inherited from a previous period of exposure rather than indicating moraine formation prior to the LGM and their subsequent survival beneath LGM ice. An implication is that Lake District glaciers achieved limited erosion of bedrock during the build‐up to and at the maximum of the LGM, and that glacial erosion rates increased at a late stage in that period. Single 36Cl and 10Be exposure ages from two sites suggest a stillstand or readvance of valley glaciers prior to the Loch Lomond (Younger Dryas) Stade (LLS; Greenland Stade 1) and Windermere (Lateglacial) Interstade (Greenland Interstade 1), but additional ages are required in order to confirm or refute these individual ages. An LLS age for glacial‐depositional landforms at both these sites had previously been proposed. 36Cl surface exposure ages for boulders on moraines within the LLS limit do not fully support emplacement at that time; there is a possibility that these moraines are associated with a pre‐LLS stillstand or readvance of the valley glacier. Copyright © 2013 John Wiley & Sons, Ltd.