Miracle-dz/UniFAR-FTUs huggingface dataset:
Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction

Fetal growth restriction (FGR) has been linked to long-term neurocognitive impairment, especially in males. To determine possible underlying mechanisms, we examined hippocampal cellular composition and mTOR signaling of male rat FGR offspring during main brain growth and development (postnatal days (PND) 1 and 12). FGR was either induced by a low-protein diet throughout pregnancy, experimental placental insufficiency by bilateral uterine vessel ligation or intrauterine stress by “sham” operation. Offspring after unimpaired gestation served as common controls. Low-protein diet led to a reduced cell density in the molecular dentate gyrus subregion, while intrauterine surgical stress was associated with increased cell density in the cellular CA2 subregion. Experimental placental insufficiency caused increased mTOR activation on PND 1, whereas intrauterine stress led to mTOR activation on PND 1 and 12. To determine long-term effects, we additionally examined mTOR signaling and Tau phosphorylation, which is altered in neurodegenerative diseases, on PND 180, but did not find any changes among the experimental groups. Our findings suggest that hippocampal cellular proliferation and mTOR signaling are dysregulated in different ways depending on the cause of FGR. While a low-protein diet induced a decreased cell density, prenatal surgical stress caused hyperproliferation, possibly via increased mTOR signaling.
A versatile technology for colloidal crystal transfer using parylene coatings and hydrosoluble polymers

We propose a novel versatile colloidal crystal transfer technique compatible with a wide range of water-insoluble substrates regardless of their size, material, and wettability. There are no inherent limitations on colloidal particles material and size. The method possibilities are demonstrated via the colloidal transfer on quartz, glass substrates with a flat and curved surface, and via the fabrication of 3D colloidal structure with 5 overlaid colloidal monolayers. The process occurs at a room temperature in water and is independent from the illumination conditions, which makes it ideal for experimental manipulations with sensitive functional substrates. We performed the nanosphere photolithography process on a photosensitive substrate with a transferred colloidal monolayer. The metallized hexagonal arrays of nanopores demonstrated a clear resonant plasmonic behavior. We believe that due to its high integration possibilities the proposed transfer technique will find applications in a large-area surface nanotexturing, plasmonics, and will speed up a device fabrication process.
1-Year Post-loading of Short and Ultrashort Implants in Posterior Mandibular and Maxillary Regions

BACKGROUND: Short implants have been proposed as an option for management of deficient alveolar ridges without the need for complex augmentation procedures. AIM: In this study, we aim to assess the use of short and ultrashort implants for the management of deficient alveolar ridges in posterior mandibular and maxillary areas with a 1-year post-loading follow-up. METHODOLOGY: Ten patients were recruited in this trial with a total of 14 implants to be placed. The patients all needed implants in the maxillary/mandibular posterior regions for prosthetic rehabilitation with deficient alveolar ridge heights. Implants of 5 mm diameter and lengths either 6 or 8.5 mm were to be placed in the edentulous spaces after proper radiographic assessment. Two-stage surgeries were followed with ¾ months between implant placement and loading. The follow-up lasted for a year to allow for peri-implant clinical assessment and radiographic analysis. RESULTS: All patients showed uneventful healing and no infection, wound dehiscence or inflammation was noted. Prosthetic rehabilitation was successful and satisfactory to the patients. None of the cases showed excessive marginal bone loss and stability was maintained at acceptable levels to the end of the follow-up period. CONCLUSION: Within the limitations of this study, short and ultrashort implants seem like a valid option for management of posterior edentulous regions with deficient ridge heights.
Lack of Awareness of IT Adoption and Use Theories by IT/IS Project Managers: Poor Relevance, Unfocused Research or Deficient Education?

Adoption, use, and diffusion of Information Technology (IT) applications, together with their widespread success, are among the most popular topics in Information Systems (IS) research. However, the impact of the acquired understanding of those phenomena on IS practice is not discernible. In fact, IT adoption, use, and diffusion are subjects scarcely mentioned in what concerns the practices of IT/IS professionals. This article addresses the question of IT/IS practitioners’ awareness of models and theories regarding the adoption, use, and diffusion of IT applications and their success. It describes two surveys of IT/IS project managers that look into their knowledge on a selected set of models/theories widely addressed in IS research. The results show that these project managers are not aware of IT adoption, use, and diffusion models/theories. The article ends with a discussion that attempts to find justifications for that evidence and stresses out the need for further research focused on translating the extant theoretical models into actionable knowledge.
The concept of one health applied to the problem of zoonotic diseases

Zoonotic diseases are a burden on healthcare systems globally, particularly underdeveloped nations. Numerous vertebrate animals (e.g., birds, mammals and reptiles) serve as amplifier hosts or reservoirs for viral zoonoses. The spread of zoonotic disease is associated with environmental factors, climate change, animal health as well as other human activities including globalization, urbanization and travel. Diseases at the human‐animal environment interface (e.g., zoonotic diseases, vector‐borne diseases, food/water borne diseases) continue to pose risk to animals and humans with a great significant mortality and morbidity. It is estimated that of 1400 infectious diseases known to affect humans, 60% of them are of animal origin. In addition, 75% of the emerging infectious diseases have a zoonotic nature, worldwide. The one health concept plays an important role in the control and prevention of zoonoses by integrating animal, human, and environmental health through collaboration and communication among osteopaths, wildlife, physicians, veterinarians professionals, public health and environmental experts, nurses, dentists, physicists, biomedical engineers, plant pathologists, biochemists, and others. No one sector, organization, or person can address issues at the animal–human–ecosystem interface alone.
The Effect of Market Orientation on the Use of Fintech and Utilization of Online-Based Marketing Technology and Its Implications on SME Marketing Performance

Changes in the business environment have encouraged SMEs to take advantage of fintech and marketing technology to improve marketing performance. Consumer behavior has changed in seeking product information and efficient transaction processes. However, not all SMEs have a clear market orientation in responding to a rapidly changing environment. This study aims to examine the effect of market orientation on the use of fintech and the use of online-based marketing technology. The study was conducted on 100 fashion-based Small and Medium Enterprises in Yogyakarta and Semarang which were selected by purposive sampling technique. The analytical tool used is WarpPLS. The findings of this study indicate that market orientation has a significant effect on the use of fintech and the use of online-based marketing technology. Market orientation has no significant effect on marketing performance. Meanwhile, the use of fintech and the use of online-based marketing technology has a significant effect on marketing performance.
A practical nomogram based on systemic inflammatory markers for predicting portal vein thrombosis in patients with liver cirrhosis

Abstract Introduction Immunothrombosis has recently been used to describe the responses/mechanisms in thrombosis. Systemic inflammatory markers are prognostic markers for a variety of thrombotic conditions; however, their potential value in predicting portal vein thrombosis (PVT) is unknown. This study aimed to establish an easy-to-use nomogram based on systemic inflammatory markers to predict portal vein thrombosis (PVT) in patients with liver cirrhosis. Patients and methods This retrospective study included 478 patients with cirrhosis between January 2013 and January 2021. Reputed systemic inflammatory markers (systemic immune-inflammation index [SII], neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], and platelet-to-lymphocyte ratio (PLR)) were measured, and the clinical data were recorded. The independent risk factors for PVT were determined using univariate analyses and multivariate logistic regression analyses, and a nomogram to predict the occurrence of PVT was established. The concordance index, receiver operating characteristic curves, and calibration plots were used to evaluate the performance of the model. Results A total of 239 patients with PVT and 239 patients without PVT were selected. In the univariate analysis, high SII, NLR, PLR, and MLR were significantly associated with PVT. NLR and PLR were independent risk factors for PVT (P < 0.05) by multivariate analysis. The nomogram had good predictive efficiency for PVT in patients with cirrhosis, with an area under the receiver operating characteristic (AUROC) curves of 0.891 (95% CI 0.862–0.919) and the calibration curves fit as well, indicating that the nomogram had good clinical application value. Conclusions PVT in patients with cirrhosis is associated with increased levels of systemic inflammatory markers. We successfully developed a practical nomogram based on NLR and PLR to accurately predict PVT, which is a practical method helping clinicians rapidly and conveniently diagnose and guide the treatment of PVT in patients with cirrhosis. Key Messages The present study is the first report on a nomogram based on systemic inflammatory markers in patients with portal vein thrombosis (PVT). The nomogram had good predictive efficiency and a good clinical application value for predicting PVT in patients with cirrhosis.
Current Methods and Pipelines for Image-Based Quantitation of Nuclear Shape and Nuclear Envelope Abnormalities

Any given cell type has an associated “normal” nuclear morphology, which is important to maintain proper cellular functioning and safeguard genomic integrity. Deviations from this can be indicative of diseases such as cancer or premature aging syndrome. To accurately assess nuclear abnormalities, it is important to use quantitative measures of nuclear morphology. Here, we give an overview of several nuclear abnormalities, including micronuclei, nuclear envelope invaginations, blebs and ruptures, and review the current methods used for image-based quantification of these abnormalities. We discuss several parameters that can be used to quantify nuclear shape and compare their outputs using example images. In addition, we present new pipelines for quantitative analysis of nuclear blebs and invaginations. Quantitative analyses of nuclear aberrations and shape will be important in a wide range of applications, from assessments of cancer cell anomalies to studies of nucleus deformability under mechanical or other types of stress.
Dietary strategies to alleviate high-stocking-density-induced stress in broiler chickens – a comprehensive review

Abstract Stocking broilers at a high density has been a strategy to optimize the area of the cage and hence increase the efficiency of broiler production. If the environmental (microclimate) conditions and rearing management are not properly managed, stocking broilers at a high density may, however, result in stressful conditions that are harmful for the production, health and welfare of broilers. To ameliorate these unfavorable effects of overcrowding stress, dietary interventions have been conducted. Probiotics, prebiotics, synbiotics, plant-derived products, vitamins, propolis, amino acids, fatty acids, etc. have been supplemented in diets to deal with the harmful impact of stress induced by a high stocking density of broilers. This review covers the detrimental effects of overcrowding-induced stress on broiler development and attempts to ameliorate those negative effects by dietary interventions.
effect of brand image and price changes on the purchase decision of cement products in the city of Palembang

This study aims to determine the effect of brand image and price changes on the purchasing decisions of cement products in Palembang (study on consumers of Baturaja cement products in Palembang). The population in this study is all consumers of cement products in Palembang in 2021. With the criteria for determining the sample, the sample in this study was 150 respondents. The multiple linear regression analysis results show that brand image has a positive and significant effect on purchasing decisions for Baturaja cement products. Price changes have a positive and significant effect on purchasing decisions for Baturaja cement products. Brand image, PT Semen Baturaja (Persero), Tbk should maintain the good image of PT Semen Baturaja (Persero), Tbk among the public because its status as a state-owned company does not guarantee to be the consumer's first choice. Price changes: It is necessary to make regular price adjustments with cement competitors because the price difference is a little more expensive, so consumers will switch to products from other companies.
Effect of Lactobacillus plantarum DAD-13 and Fructo-oligosaccharides on Short-Chain Fatty Acid Profile and Nutritional Status in Indonesian Stunting Children

BACKGROUND: Chronic gut inflammation is a generalized disturbance of small intestine structure and function is likely to play a large role in the incidence of stunting. It will be disturbances the absorption of nutrients, therefore, it can indirectly reduce on nutritional status. AIM: The aim of this study is to examine the effect of Lactobacillus plantarum DAD-13 and fructooligosaccharide on short-chain fatty acid (SCFA) profile and nutritional status in Indonesian stunting children. METHODS: The study design was used double-blind randomized placebo-controlled trial, 39 stunting children under five received daily oral supplementations of L. plantarum DAD-13 1 × 1010 cfu and fructooligosaccharide 700 mg (symbiotic group) or placebo group for 90 days. SCFA profile was analyzed using gas chromatography and nutritional status was assessed by WAZ, HAZ, and WHZ. RESULTS: The result shows in symbiotic and control group, the mean age was 26 ± 8.34 and 29 ± 5.78, and the mean weight was 8.5 ± 0.94 kg and 9.0 ± 0.82 kg, while the mean height was 78.96 ± 5.4 cm and 80.9 ± 4.55 cm, respectively. Concentrations of acetate, propionate, and butyrate in the symbiotic group after consumption were 17.10 ± 2.97, 7.70 ± 2.05, and 7.47 ± 1.76 while in placebo group 12.44 ± 3.61, 5.20 ± 1.66, and 6.12 ± 1.16, respectively. There was a significant difference in the mean SCFA concentration between the symbiotic and placebo groups (p < 0.05), where the SCFA concentration in the symbiotic group was significantly higher than the placebo group. Nutritional status (WAZ, HAZ, and WHZ) was observed significantly in symbiotic group (p < 0.05), only on WHZ has cutoff point >-2SD after the intervention, while WAZ and HAZ <-2SD. CONCLUSIONS: L. plantarum DAD-13 and fructooligosaccharide 90 days supplementation have increase acetate, butyrate, and propionate that are important fuels for intestinal epithelial cells that can play an important role in the maintenance of health.
Single Versus Multiple Resilience Factors: An Investigation of the Dimensionality of the Academic Resilience Scale

The Academic Resilience Scale (ARS) was developed to measure resilience factors in educational contexts. However, there is no clarity on whether the scale could be used as a measure of unidimensional academic resilience scores or just to obtain multidimensional academic resilience factors. How a scale is scored can affect the validity of inferences based on scores obtained by using the scale in research and practice. This study uses confirmatory factor analysis (CFA) and ancillary bifactor measures to examine the dimensionality of the scale. There was no sufficient support for using the scale to obtain unidimensional academic resilience score. Rather, the scale should only be considered as a measure of multiple dimensions of academic resilience factors.
Understanding the development of oral epithelial organs through single cell transcriptomic analysis

During vertebrate craniofacial development, the oral epithelium begins as a simple and morphologically homogeneous tissue. It then gives rise to locally complex structures, including the developing teeth, salivary glands, and taste buds. While there is significant knowledge about the molecular mechanisms regulating the morphogenesis of these organs at later stages, how the epithelium is initially patterned and specified to generate diverse cell types and organs remains largely unknown. To elucidate the genetic programs that direct the formation of distinct oral epithelial populations, we mapped the transcriptional landscape of embryonic day (E) 12 mouse mandibular epithelia at single cell resolution. Our analysis identified key transcription factors and gene regulatory networks that define different epithelial cell types as well as regions patterned along the oral-aboral axis. By examining the spatiotemporal expression of region-specific markers in embryonic mandibles, our results pointed to a model where the dental field is progressively confined to its position by the formation of the aboral epithelium anteriorly and the non-dental oral epithelium posteriorly. Using our data, we also identified Ntrk2 as a promoter of cell proliferation in the forming incisor, contributing to its invagination. Together, our results provide a detailed transcriptional atlas of the developing mandibular epithelium and unveil new genetic markers and regulators that are present during the specification of various oral epithelial structures.
The Antecedents of Nonprofit Board Interlock: A Longitudinal Examination on Network Structure, Homophily, and Organizational Attributes

A board interlock creates interorganizational networks where organizations are interconnected via overlapping board of directors. Board interlock is important for nonprofits because of its potential to impact organizational performance through the flow of information, resources, and status. While much is known about the consequences of board interlock, little is known about the mechanisms underlying its antecedents. This study explores three types of predictors of board interlock: organizational, dyadic, and structural characteristics. Inferential network analysis of a 17-year-period panel of nonprofits demonstrates that network relationships are shaped by the existing network structures, such as the tendency for preferential attachment (e.g., a social preference to connect with those who are already well connected) and transitivity (e.g., a social preference to connect with friends of friends). Findings inform nonprofit leaders about how to bridge to a board interlock network by recruiting well-connected board members serving on multiple boards.
Experimental investigation on mechanical properties of nanocomposites based on poly lactic acid/ polyolefin elastomer reinforced with multi-walled carbon nanotubes, and graphene nanoplatelets

The mechanical properties of nanocomposites based on poly lactic acid/polyolefin elastomer (PLA/POE) were investigated. The compounds were made using an internal mixer. POE in two levels at 10–20 wt. % and nano fillers, including multi-walled carbon nanotubes (MWCNT) and graphene nano-platelets (GnPs) in 1, 2, and 3 wt. % levels, were added to the PLA. Impact and tensile tests were conducted to extract the impact and tensile properties, respectively. The dispersion quality of the fillers was also studied by using field-emission scanning electron microscopy (FESEM) images. The FESEM images demonstrated that the MWCNT at all levels were well distributed in different orientations, while the GnPs accumulated into the PLA/POE matrix. The simultaneous presence of nano fillers was dispersed with high quality in the matrix only in low loading. The tensile test results showed that by increasing the nano fillers individually and in a hybrid form in the presence of different loadings of POE, Young’s modulus and T-strength were improved, but impact strength and deformation at break were decreased. The addition of the POE to the PLA matrix significantly increased the impact strength and deformation at break by 128% and 75%, respectively, and the presence of POE reduced Young’s modulus and T-strength of the PLA matrix.
Heavy Metal Effects on Biodiversity and Stress Responses of Plants Inhabiting Contaminated Soil in Khulais, Saudi Arabia

Simple Summary Despite its high organic matter content, sewage sludge contains significant quantities of heavy metals, including those designated as hazardous, such as cadmium, nickel, chromium, mercury, copper, lead, and zinc, which, as a consequence, have a negative impact on living organisms. The current research sought to study the effect of dumping sludge, as one of the sources of pollution with heavy metals, on biodiversity and to assess the bioremediation and stress defense strategies of a tolerant plant species. The obtained results showed that soil pollution by heavy metals has a substantial influence on plant diversity. The selected species, Amaranthus retroflexus L. , showed a high biological concentration factor (BCF) and low translocation factor (TF) for Cu, As and Ni. The stress defense strategies of A. retroflexus grown under complex heavy metals contamination are studied and discussed. Abstract Accumulation of heavy metals in soil is becoming an increasingly serious eco-environmental problem. Thus, investigating how plants mitigate heavy metal toxicity is necessary to reduce the associated risks. Here, we aimed to assess the bioremediation and stress defense strategies of tolerant plant species grown under complex heavy metals contamination. To this end, a field study was conducted on the vegetation cover of sites with different soil pollution levels. Forty-two plant species that belong to 38 genera and 21 families were identified. The pollution had a significant impact on plant richness in the polluted sites. Out of several screened plants, Amaranthus retroflexus L. was selected because of its high relative density (16.7) and a high frequency (100%) in the most polluted sites. The selected species showed a high biological concentration factor (BCF) and low translocation factor (TF) for Cu, As and Ni. To control the heavy metal-induced oxidative damage, A. retroflexus invested in detoxification (metallothionein and phytochelatins, glutathione and glutathione-S-transferase (GST). At the organ level, oxidase damage (H2O2, lipid and protein peroxidation) was observed, particularly in the roots. To mitigate heavy metal oxidative stress, antioxidant mechanisms (e.g., tocopherols, glutathione, peroxidases, catalase, peroxide dismutase and ASC-GSH cycle) were upregulated, mainly in the roots. Overall, our results suggested the potentiality of A. retroflexus as a promising bioremediatory and stress-tolerant plant at the same time; moreover, defense and detoxification mechanisms were uncovered.