Miracle-dz/UniFAR-FTUs huggingface dataset:
The Lithospheric Mantle beneath Continental Margins: Melting and Melt–Rock Reaction in Canadian Cordillera Xenoliths

Seven alkali basalt centers in the southern Canadian Cordillera INTRODUCTION contain mantle xenolith suites that comprise spinel Cr-diopside Spinel peridotite xenoliths occur in many alkali basalt peridotites, spinel augite-bearing wehrlites and orthopyroxene-poor centers of the Canadian Cordillera, a Phanerozoic conlherzolites, and minor pyroxenites. The Cr-diopside peridotites vergent orogen bordering the western edge of the Caappear to be residues of the extraction of Mg-rich basalts by up to nadian craton. The Cordillera formed during the late 15% partial melting (median 5–10%) of a pyrolite-like source in Jurassic and Cretaceous through the successive accretion the spinel stability field. The xenoliths are similar to other mantle of tectonic terranes of various lithologies (mainly arc xenolith suites derived from beneath convergent continental margins, related) to the stable margin of ancestral North America but are less depleted, less oxidized, and have lower spinel mg(e.g. Monger et al., 1982; Gabrielse & Yorath, 1991). number than peridotites found in fore-arc settings. Their dominant However, the nature of the lithospheric mantle beneath high field strength element depleted character, however, is typical of these terranes and its tectonic origin are poorly conarc lavas, and may suggest that fluids or melts circulating through strained. Moreover, the southern part of this continental the Canadian Cordillera lithosphere were subduction related. Modmargin is bordered by an active subduction zone (Gaeling using MELTS is consistent with the augite-bearing xenoliths brielse et al., 1991), and thus the lithosphere may have being formed by interaction between crystallizing alkaline melts and been modified by subduction-related melts or fluids. The peridotite. Assimilation–fractional crystallization modeling suggests mantle xenoliths thus represent samples of the lithospheric that the trace element patterns of liquids in equilibrium with the mantle at the transition between cratonic continental augite xenoliths may represent the initial melts that reacted with the lithosphere and oceanic mantle. The major element peridotite. Moreover, the compositions of these melts are similar to composition of the mantle lithosphere is of interest as a those of some glasses observed in the mantle xenoliths. Melt–rock potential source of magmas and also because it may react interaction may thus be a viable mechanism for the formation of with magmas migrating through it on their way to the Siand alkali-rich glass in peridotites. surface.
Associations between hypothyroidism and adverse obstetric and neonatal outcomes: a study of a population database including over 184,000 women with hypothyroidism

Abstract Background Maternal hypothyroidism has been associated with multiple adverse pregnancy outcomes. These findings have not been confirmed in a large population database study. Therefore, a large population-based cohort study was established to study the associations between maternal hypothyroidism and pregnancy and perinatal complications. Methods This is a retrospective population-based cohort study utilizing data from the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) over 11 years from 2004 to 2014. A cohort of all deliveries between 2004 and 2014 inclusive, was created. Within this group, all deliveries to women with hypothyroidism were identified as part of the study group (n = 184,869), and the remaining deliveries were categorized as non-hypothyroidism births and comprised the reference group (n = 8,911,919). The main outcome measures were pregnancy and perinatal complications. Results Maternal hypothyroidism is associated with several pregnancy and perinatal complications, including gestational diabetes mellitus (aOR 1.43, 95%CI 1.38–1.47), gestational hypertension (aOR 1.17, 95%CI 1.11–1.22) and preeclampsia (aOR 1.21, 95%CI 1.16–1.27) (all p < 0.001). These patients are more likely to experience preterm premature rupture of membranes (aOR 1.19, 95%CI 1.09–1.29, p < 0.001), preterm delivery (aOR 1.12 95%CI 1.08–1.17, p < 0.001), are more likely to deliver by cesarean section (aOR 1.21, 95% CI 1.18–1.24, p < 0.001), and suffer from postpartum hemorrhage (aOR 1.07, 95%CI 1.01–1.13, p = 0.012), disseminated intravascular coagulation (aOR 1.20, 95%CI 1.00-1.43, p = 0.046), and undergo hysterectomy (aOR 1.42, 95% CI 1.13–1.80, p = 0.003). As for neonatal outcomes, small for gestational age and congenital anomalies are more likely to occur in the offspring of women with hypothyroidism (aOR 1.20, 95% CI 1.14–1.27 and aOR 1.34, 95% CI 1.22–1.48, both p < 0.001). Conclusions Women with hypothyroidism are more likely to experience pregnancy, delivery and neonatal complications. We found an association between hypothyroidism and hypertensive disorders, postpartum hemorrhage, transfusions, infections, preterm delivery and hysterectomy, among other problems. This data from a population sized database confirms the findings of smaller previous studies in the literature.
Arrhythmic risk stratification in arrhythmogenic right ventricular cardiomyopathy

Abstract Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable cardiomyopathy characterized by a predominantly arrhythmic presentation. It represents the leading cause of sudden cardiac death (SCD) among athletes and poses a significant morbidity threat in the general population. As a causative treatment for ARVC is still not available, the placement of an implantable cardioverter defibrillator represents the current cornerstone for SCD prevention in this setting. Thanks to international ARVC-dedicated efforts, significant steps have been achieved in recent years towards an individualized, patient-centred risk stratification approach. A novel risk calculator algorithm estimating the 5-year risk of arrhythmias of patients with ARVC has been introduced in clinical practice and subsequently validated. The purpose of this article is to summarize the body of evidence that has allowed the development of this tool and to discuss the best way to implement its use in the care of an individual patient.
Osimertinib with or without Chemotherapy in EGFR-Mutated Advanced NSCLC.

BACKGROUND Osimertinib is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) that is selective for EGFR-TKI-sensitizing and EGFR T790M resistance mutations. Evidence suggests that the addition of chemotherapy may extend the benefits of EGFR-TKI therapy. METHODS In this phase 3, international, open-label trial, we randomly assigned in a 1:1 ratio patients with EGFR-mutated (exon 19 deletion or L858R mutation) advanced non-small-cell lung cancer (NSCLC) who had not previously received treatment for advanced disease to receive osimertinib (80 mg once daily) with chemotherapy (pemetrexed [500 mg per square meter of body-surface area] plus either cisplatin [75 mg per square meter] or carboplatin [pharmacologically guided dose]) or to receive osimertinib monotherapy (80 mg once daily). The primary end point was investigator-assessed progression-free survival. Response and safety were also assessed. RESULTS A total of 557 patients underwent randomization. Investigator-assessed progression-free survival was significantly longer in the osimertinib-chemotherapy group than in the osimertinib group (hazard ratio for disease progression or death, 0.62; 95% confidence interval [CI], 0.49 to 0.79; P<0.001). At 24 months, 57% (95% CI, 50 to 63) of the patients in the osimertinib-chemotherapy group and 41% (95% CI, 35 to 47) of those in the osimertinib group were alive and progression-free. Progression-free survival as assessed according to blinded independent central review was consistent with the primary analysis (hazard ratio, 0.62; 95% CI, 0.48 to 0.80). An objective (complete or partial) response was observed in 83% of the patients in the osimertinib-chemotherapy group and in 76% of those in the osimertinib group; the median response duration was 24.0 months (95% CI, 20.9 to 27.8) and 15.3 months (95% CI, 12.7 to 19.4), respectively. The incidence of grade 3 or higher adverse events from any cause was higher with the combination than with monotherapy - a finding driven by known chemotherapy-related adverse events. The safety profile of osimertinib plus pemetrexed and a platinum-based agent was consistent with the established profiles of the individual agents. CONCLUSIONS First-line treatment with osimertinib-chemotherapy led to significantly longer progression-free survival than osimertinib monotherapy among patients with EGFR-mutated advanced NSCLC. (Funded by AstraZeneca; FLAURA2 ClinicalTrials.gov number, NCT04035486.).
Assessing Potential Seasonal Predictability with an Ensemble of Multidecadal GCM Simulations

Abstract A global search for areas where seasonal prediction may be feasible has attracted scientific interest for many years. This contribution is based primarily on data from a six-member ensemble of 45-yr climate runs, each of which is forced by observed sea surface temperatures (SSTs) and sea-ice extents and are unique only in their initial atmospheric conditions. The potentially predictable component of atmospheric interannual variability is assumed to be that due to oceanic forcing, and using “analysis of variance,” this is separated from the unpredictable internal component; potential predictability is measured as the ratio of ocean-forced variance to total variance. Significance levels and confidence intervals are calculated, both of which are essential for a meaningful interpretation of predictability estimates; the latter show there is low susceptibility to sampling problems here because of the large data source available. Global maps of potential predictability, for simulated seasonal mean prec.
Inotodiol ameliorates the progression of osteoarthritis: An in vitro and in vivo study

Abstract Osteoarthritis is a common chronic degenerative disease, of which the essence is the degenerative changes of bone and joint cartilage, involving damage in multiple structures such as bone, synovium and joints. In the mechanism of arthritis inflammation is closely related, and therefore the exploration to inhibit inflammatory mediators is crucial for the clinical prevention and treatment of osteoarthritis. Inotodiol is a lanostane triterpenoid isolated from Inonotus obliquus, which had been extensively reported to be an anti-inflammatory agent, but its effect on arthritis remains unknown. In this study, we firstly demonstrated that inotodiol significantly reduced IL-1β-induced chondrocyte injury and inhibited the release of inflammatory factors. At the same time, experiments in vivo showed that inotodiol could effectively improve the symptoms of joint injury in mice and reduce the area of cartilage destruction, indicating that inotodiol may be a potential therapeutic drug for osteoarthritis.
The possible protective role of selenium on the visual cortex of adult albino rat on exposure to potassium dichromate

ABSTRACT The visual cortex is very important in mammals for processing of visual information. Exposure to heavy metals such as potassium dichromate poses serious health threat to human beings. The aim of this work is to study the effect of potassium dichromate on the visual cortex of adult albino rat and also to identify the possibility of selenium as protective agent against toxicity of potassium dichromate. A total number of 40 adult albino rats weighting (200–250) gm were used. They divided into four groups: control group, potassium dichromate received group, potassium dichromate and selenium received group and selenium received group. The rats received treatment for 6 weeks. After 6 weeks, they were sacrificed. The present study showed that potassium dichromate causes degeneration of granular neurons in layer IV and pyramidal neurons in layer V. Morphometric results revealed statistically significant decrease in the number of granule and pyramidal cells in potassium dichromate received group as compared with control group. Most of degenerative changes are improved by selenium. الملخص العربي الدور الوقائي المحتمل للسيلينيوم على القشرة المخية البصرية للفأر الابيض البالغ عند التعرض للدايكرومات البوتاسيوم سالي سيد أنور-هالة محمد حسانين قسم التشريح الادمي وعلم الاجنة -كلية الطب البشرى- جامعة اسيوط القشرة البصرية مهمة جدا في الثدييات لمعالجة المعلومات المرئية. يشكل التعرض للمعادن الثقيلة مثل ثنائي كرومات البوتاسيوم تهديداً صحياً خطيراً للإنسان. الهدف من هذا العمل هو دراسة تأثير ثنائي كرومات البوتاسيوم على القشرة البصرية لجرذ ألبينو البالغ وكذلك التعرف على إمكانية استخدام السيلينيوم كعامل وقائي ضد سمية ثنائي كرومات البوتاسيوم. تم استخدام جرذ من الجرذان البالغة وزنها (200-250) جرام. تم تقسيمهم إلى 4 مجموعات: المجموعة 40الضابطة ، المجموعة المستلمة ثنائي كرومات البوتاسيوم ، المجموعة المستلمة ثاني كرومات البوتاسيوم والسيلينيوم المجموعة المستلمة سيلينيوم تلقتالفئران العلاج لمدة 6 أسابيع. بعد ستة أسابيع تم التضحية بهم. أظهرت الدراسة الحالية أن ثنائي كرومات البوتاسيوم يسبب تنكس الخلايا العصبية الحبيبية في الطبقة الرابعة والخلايا العصبية الهرمية في الطبقة الخامسة. أظهرت نتائج القياس المورفومتري انخفاضًا ذا دلالة إحصائية في عدد الخلايا الحبيبية والهرمية في المجموعة التي تم تلقيها من ثنائي كرومات البوتاسيوم مقارنة بمجموعة التحكم. يتم تحسين معظم التغييرات التنكسية بواسطة السيلينيوم.
The effects of day and night humidity on yield and quality of glasshouse cucumbers

SummaryThe effects of different day and night humidity levels on autumn- and spring-grown cucumbers were examined in four glasshouse experiments. A high or low humidity during the day was combined with either a high or low humidity during the night to give four treatment combinations. The vapour pressure deficits achieved, over the total period, varied from 0.57 to 0.91 kPa by day, from 0.26 to 0.66 kPa by night, and the 24-h average varied from 0.43 to 0.75 kPa. Temperature differences between the treatments were less than 0.6°C in each experiment. Vegetative growth was enhanced by either high day or night humidity but early yield was not related to either day, night, or 24-h average humidity. A significant negative correlation was found between vapour pressure deficit by day and final total yield in all but one experiment. Fruit quality, expressed as fruit colour, was reduced by a high 24-h average humidity. Calcium deficiency in leaves was correlated with 24-h average humidity. From the viewpoint of pr.
A sociological study of Old persons residing in an Old age Home of Delhi, India

Government efforts are increasing rapidly in the field of contemporary, social, economic, public interest and other factors to reduce maltreatment against the old citizens. But in the present time, the situation against the old persons is changing, people have started hated them, they forcefully made them to move from their own homes. Due to this they become homeless and may move to old age homes. This article is based on the various demands of old citizens. This article has been taken from an old age home of Delhi, which is working in the field of protection of old people rights to make clear the need of study.
Variation in agronomic performance and grain quality of Indian maize landraces of high altitude region of Jammu Kashmir and Himachal Pradesh

India has a vast diversity in maize landraces characteristics grown under different agro ecologies. In this study, the landraces of Norh-western Himalayan region were studied for their variability for agronomic and biochemical traits. The landraces were evaluated in Delhi during rainy seasons of 2008 and 2009. There were significant difference between landraces of Jammu Kashmir and Himachal Pradesh for protein content, tryptophan content, test weight, days to tassel, days to silk, plant height, ear height and number of kernel rows. Based on coeeficient of variance, landarces of Himachal Pradesh were more variable in comparison to Jammu Kashmir. Altogether landraces of both the places were variable for yield per plant, test weight, ear height and tryptophan content. The boxplot depicted that landraces of Jammu Kashmir has more average value of protein, oil, sugar and starch content whereas landraces of Himachal Pradesh has more content of tryptophan and specific gravity.
Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview

Background: There is a growing interest in studying ibogaine (IBO) as a potential treatment for substance use disorders (SUDs). However, its clinical use has been hindered for mainly two reasons: First, the lack of randomized, controlled studies informing about its safety and efficacy. And second, IBO’s mechanisms of action remain obscure. It has been challenging to elucidate a predominant mechanism of action responsible for its anti-addictive effects. Objective: To describe the main targets of IBO and its main metabolite, noribogaine (NOR), in relation to their putative anti-addictive effects, reviewing the updated literature available. Methods: A comprehensive search involving MEDLINE and Google Scholar was undertaken, selecting papers published until July 2022. The inclusion criteria were both theoretical and experimental studies about the pharmacology of IBO. Additional publications were identified in the references of the initial papers. Results: IBO and its main metabolite, NOR, can modulate several targets associated with SUDs. Instead of identifying key targets, the action of IBO should be understood as a complex modulation of multiple receptor systems, leading to potential synergies. The elucidation of IBO’s pharmacology could be enhanced through the application of methodologies rooted in the polypharmacology paradigm. Such approaches possess the capability to describe multifaceted patterns within multi-target drugs. Conclusion: IBO displays complex effects through multiple targets. The information detailed here should guide future research on both mechanistic and therapeutic studies.
An effective Linear Independence conjecture for the zeros of the Riemann zeta function and applications

Using the same heuristic argument leading to the Lang-Waldschmidt Conjecture in the theory of linear forms in logarithms, we formulate an effective version of the Linear Independence conjecture for the ordinates of the non-trivial zeros of the Riemann zeta function. Then assuming this conjecture, we obtain Omega results for the error term in the prime number theorem, which are conjectured to be best possible by Montgomery. This was claimed to appear in Monach's thesis by Montgomery and Vaughan in their classical book, but such a result or its proof is nowhere to be found in this thesis or in the litterature. Moreover, if in addition to this effective Linear Independence conjecture we assume a conjecture of Gonek and Hejhal on the negative moments of the derivative of the Riemann zeta function, we can show that the summatory function of the M\"obius function $M(x)$ is $\Omega_{\pm}\left(\sqrt{x}(\log\log\log x)^{5/4}\right)$. This conditionally resolves a part of a conjecture of Gonek.
Functional Bayesian Tucker Decomposition for Continuous-indexed Tensor Data

Tucker decomposition is a powerful tensor model to handle multi-aspect data. It demonstrates the low-rank property by decomposing the grid-structured data as interactions between a core tensor and a set of object representations (factors). A fundamental assumption of such decomposition is that there are finite objects in each aspect or mode, corresponding to discrete indexes of data entries. However, real-world data is often not naturally posed in this setting. For example, geographic data is represented as continuous indexes of latitude and longitude coordinates, and cannot fit tensor models directly. To generalize Tucker decomposition to such scenarios, we propose Functional Bayesian Tucker Decomposition (FunBaT). We treat the continuous-indexed data as the interaction between the Tucker core and a group of latent functions. We use Gaussian processes (GP) as functional priors to model the latent functions. Then, we convert each GP into a state-space prior by constructing an equivalent stochastic differential equation (SDE) to reduce computational cost. An efficient inference algorithm is developed for scalable posterior approximation based on advanced message-passing techniques. The advantage of our method is shown in both synthetic data and several real-world applications. We release the code of FunBaT at \url{https://github.com/xuangu-fang/Functional-Bayesian-Tucker-Decomposition}.
Enriched mantle source for Palcoproterozoic high Mg and low Ti-P mafic dykes in central part of the North China craton:constraints from zircon Hf isotopic compositions

Paleoproterozoic mafic dyke swarms in central part of the North China craton can be divided into two types: metamorphosed and unmetamorphosed.The unmetamorphosed dykes formed in a short duration of～20Ma from 1780 to 1760Ma and were produced by the latest Paleoproterozoic mafic mgmatism in the North China eraton.They may be subdivided into following three groups:high Mg-Ti and low P,low Mg and high Ti-P,and high Mg and low Ti-P,and individual groups have different geochemical features.A new zircon U-Pb age obtained for the high Mg and low Ti-P marie dykes to the northwest of Fengzhen city is 1769±4Ma, in good agreement with previous data such as ~(40)Ar/~(39)Ar and conventional and SHRIMP zircon and baddeleyite U-Pb ages for the unmetamorphosed dykes. Thee_(Hf)(t)values of the dated zircons at 1770Ma vary from-6.4 to+0.4,with an average of -2.2,and are slightly higher than those of the granitic rocks formed at similar time,indicating that the magmas,with little crustal contamination during their ascent,emplacement and crystallization,were derived from an enriched source from the subcontinental lithospheric mantle induced by subducted sediments.In addition,the enriched mantle source for the high Mg and low Ti-P mafic dykes had thee_(Nd)(t) values of - 5.6 to -2.8(average -4.4)and the initial ~(87)St/~(S6)Sr ratios of 0.7040 to 0.7050(average 0.7046),as shown by the data available from the literature.
The existence of inversive distance circle packing on hyperbolic polyhedral surface

In this paper, we prove that given a hyperbolic polyhedral metric with an inversive distance circle packing, and a target discrete curvature satisfying Gauss-Bonnet formula, there exist a unique inversive distance circle packing which is discrete conformal to the former one. We deform the surface by discrete Ricci flow, and do surgery by edge flipping when the orthogonal circles of some faces are about to be non-compact. The revised weighted Delaunay inequality of hyperbolic case implies the compactness of the orthogonal circle. We use a variational principle of a convex Ricci potential defined on the fiber bundles with cell-decomposition and differential structure based on Teichm\"uller space to finish the proof.
A Short Report on the Probability-Based Interpretation of Quantum Mechanics

This paper calls attention to the sad state of the probability (P) domain which presents significant weak points at the mathematical level and even more at the application level. It is noticed how significant issues raised in quantum mechanics (QM) directly mirror unresolved probabilistic questions. Endless philosophical debates create more problems than solutions, so the author suggests going directly to the root of the issues and searching for the probability theory which formalizes the multifold nature of P. This paper offers a brief overview of the structural theory of probability that has been recently published in a book, and that underpins a probability-based interpretation of QM. The entire work goes beyond the limits of a paper and these pages condense a few aspects of this theoretical inquiry. The double slit experiment is used to corroborate the theorems presented here.