Miracle-dz/UniFAR-FTUs huggingface dataset:
A CNN-based rescaling algorithm and performance analysis for spatial resolution enhancement of Landsat images

ABSTRACT This study aimed to propose a new convolutional neural network (CNN)-based model for spatial resolution enhancement of Landsat images without finer resolution bands for training the CNN-based model. Its performance was assessed using Landsat 8 images from eight different regions that were dominated by various topographic features, and land use and land cover types by comparison with bicubic (BIC), nearest neighbor (NN) and Lanczos (LZ) resampling. It was found that for spatial resolution enhancement of 30 m resolution images to 15 m, 10 m and 7.5 m, the proposed model increased the average peak-signal-to-noise-ratio (PSNR) values by 1.7% to 11.5% compared with the compared methods. The PSNR increases were statistically significantly different from zero at the significant level of . 05, but the improvement decreased as the spatial resolution of the input images became finer. Moreover, the deeper the CNN model, the better the performance, but after nine layers, the gain of performance slowed down. This indicates that the proposed algorithm is promising for spatial resolution enhancement of optical images without input of finer spatial resolution images.
Social Climate and Psychological Response in the First Wave of the COVID-19 Pandemic in a Greek Academic Community

This study examines how the social climate was associated with the psychological response during the first wave of the COVID-19 pandemic. Using a structural equation model linking the economic crisis to the social climate (pandemic fear, social and psychological distress, civil protection, and population’s response) and to the psychological response (perspectives of life and reconsidering values), we tested their multivariate relationships in a Greek academic community sample. At the first level of the model, the economic crisis was significantly associated with the social climate: pandemic fear, social/psychological distress, and civil protection. At the second level, social/psychological distress was associated with the pandemic fear and civil protection, whereas the pandemic fear was associated with the population’s response to governmental measures. At the third level, civil protection was directly associated with the psychological response resilience variables: perspectives of life and reconsidering values. The model explained a significant amount of the variance in the population’s response (62%), reconsidering values (42%), and perspectives of life (32%). Moreover, women presented higher levels of social/psychological distress, pandemic fear, and perspectives of life. Finally, younger people were more affected by the social/psychological distress and pandemic fear, whereas older people presented higher levels in the population’s response to governmental measures.
The evolving contribution of R&D, advertising and capital expenditures for US-listed firms’ growth in sales, 1979-2018. A quantile regression analysis

This article presents new insights on the evolving contribution of di ff erent types of investments to the growth in sales of US non fi nancial listed fi rms during the 1979-2018 period. By means of quantile regressions it is observed an increasing contribution over time of intangible investment vis-à-vis a decline in capital expenditure both for high-growth and slow-growth fi rms. However, the impact of di ff erent types of intangible investment di ff ers depending on the kind of fi rm. Whereas research and development (R&D) has a positive contribution for high-growth fi rms, only advertising has a positive e ff ect for their slow-growth peers.
Migraine and Neuroticism: A Scoping Review

Headache is the first cause of consultation in neurology, and one of the most frequent reasons for consultation in general medicine. Migraine is one of the most common, prevalent, and socioeconomically impactful disabling primary headache disorders. Neuroticism can be conceptualized as a disposition to suffer anxiety and emotional disorders in general. Neuroticism has been associated with various mental and physical disorders (e.g., chronic pain, depression), including migraine. With the aim to explore in depth the relationship between migraine and neuroticism, and contribute to the understanding of this relation in order to provide a better treatment for migraine patients based on a personalized and more comprehensive approach, a scoping review was performed using PubMed, Scopus, and Web of Science. Databases were searched independently by the two researchers, reaching a final set of 18 articles to be included. The search terms were: migraine and neuroticism. Neuroticism seems to be highly prevalent in migraine patients. Findings reveal that migraine patients with comorbid depression and anxiety showed higher levels of neuroticism. Depression has been associated with an increased risk of transformation from episodic to chronic migraine whereas neuroticism might be a mediator factor. Neuroticism also might be a mediator factor between childhood maltreatment and migraine. The revision conducted confirms that: (1) Migraine patients usually have a higher level of neuroticism and vulnerability to negative affect, compared to non-migraineurs and tension-type headache patients. (2) Neuroticism is associated with migraine. Nonetheless, more research is needed to clarify potential moderators of this relationship and the role of neuroticism itself in this disease. This knowledge might be useful in order to promote a better management of negative emotions as part of intervention programs in migraine.
Improvement of U.S. EPA minimum risk essential oils' pesticide activity through surfactant enhancement and synergy

Plant essential oils have been used since antiquity for many purposes, including pest control in agriculture and against nuisance pests such as mosquitoes, flies and ticks. In recent years, consumers have increasingly expressed interest in purchasing organically grown foods, as well as using natural and naturally derived materials to eradicate pests in their lawn, garden and homes. In 1996, the U.S. Environmental Protection Agency established a list, referred to as the 25(b) list, containing 31 active ingredients deemed minimum risk. Companies developing pesticides using active ingredients from the 25(b) list are exempt from federal registration requirements, providing a financial incentive to develop such products as well as fill growing consumer demand. There are 14 plant essential oils and essential oil constituents on the 25(b) list with proven pesticide properties, but there is little public information comparing efficacy of these ingredients. This study compared 14 essential oils and essential oil constituents from the 25(b) list in insecticidal and herbicidal contact bioassays: cedar oil, cinnamon oil, citronella oil, clove oil, eugenol, garlic oil, geraniol, geranium oil, lemongrass oil, mint oil, peppermint oil, rosemary oil, thyme oil, and 2-phenethyl propionate. Their performance as single active ingredients and as pairwise combinations with one another within liquid formulations was evaluated for additive or synergistic benefits. In contact insecticidal assays using 9th instar American cockroach (Periplaneta americana) nymphs, there was a significant
Performance Evaluation and Water Availability of Canal Irrigation Scheme in Punjab Pakistan

The supply of surface water by century-old infrastructure causes substantial water loss and triggers huge abstractions of groundwater, resulting in low irrigation efficiency. We evaluated the irrigation performance (application and conveyance efficiencies) and water availability (supply-demand) from the field to the Mungi Distributary canal level in Punjab, Pakistan. Between April–September 2019 and 2020, we monitored water delivery in the canal network, soil moisture content in cotton fields, and the canal and groundwater quality. The crops’ actual evapotranspiration was estimated using the AquaCrop model. We found conveyance efficiencies >90% for minor distributaries, 70–89% for watercourses, and ~75% for field ditches per kilometer. Field application efficiency was >90% for drip and ~35% for flood basin, whereas for raised-bed furrow, conventional furrow, and ridge-furrow irrigation methods, it varied between 44% and 83%. The deficits of canal water supply versus demand for cotton fields ranged from 45% to 73%, whereas the Mungi Distributary canal water showed a 68.6% and 19.8% shortfall in the April–September and October–March seasons of 2018/2019, respectively. The study suggests prioritizing improvements to field water application rather than canals with better water quality; additionally, surplus water from the Mungi canal in November and December could be stored for later use.
The Role of TRPM4 Gene Mutations in Causing Familial Progressive Cardiac Conduction Disease: A Further Contribution

Progressive cardiac conduction disease (PCCD) is a relatively common condition in young and elderly populations, related to rare mutations in several genes, including SCN5A, SCN1B, LMNA and GJA5, TRPM4. Familial cases have also been reported. We describe a family with a large number of individuals necessitating pacemaker implantation, likely due to varying degrees of PCCD. The proband is a 47-year-old-patient, whose younger brother died at 25 years of unexplained sudden cardiac death. Three paternal uncles needed a pacemaker (PM) implantation between 40 and 65 years for unspecified causes. At the age of 42, he was implanted with a PM for two episodes of syncope and the presence of complete atrioventricular block (AVB). NGS analysis revealed the missense variation c. 2351G>A, p.Gly844Asp in the exon 17 of the TRPM4 gene. This gene encodes the TRPM4 channel, a calcium-activated nonselective cation channel of the transient receptor potential melastatin (TRPM) ion channel family. Variations in TRPM4 have been shown to cause an increase in cell surface current density, which results in a gain of gene function. Our report broadens and supports the causative role of TRPM4 gene mutations in PCCD. Genetic screening and identification of the causal mutation are critical for risk stratification and family counselling.
Test and Validation of the Surrogate-Based, Multi-Objective GOMORS Algorithm against the NSGA-II Algorithm in Structural Shape Optimization

Nowadays, product development times are constantly decreasing, while the requirements for the products themselves increased significantly in the last decade. Hence, manufacturers use Computer-Aided Design (CAD) and Finite-Element (FE) Methods to develop better products in shorter times. Shape optimization offers great potential to improve many high-fidelity, numerical problems such as the crash performance of cars. Still, the proper selection of optimization algorithms provides a great potential to increase the speed of the optimization time. This article reviews the optimization performance of two different algorithms and frameworks for the structural behavior of a b-pillar. A b-pillar is the structural component between a car’s front and rear door, loaded under static and crash requirements. Furthermore, the validation of the algorithm includes a feasibility constraint. Recently, an optimization routine was implemented and validated for a Non-dominated Sorting Genetic Algorithm (NSGA-II) implementation. Different multi-objective optimization algorithms are reviewed and methodically ranked in a comparative study by given criteria. In this case, the Gap Optimized Multi-Objective Optimization using Response Surfaces (GOMORS) framework is chosen and implemented into the existing Institut für Konstruktionstechnik Optimizes Shapes (IKOS) framework. Specifically, the article compares the NSGA-II and GOMORS directly for a linear, non-linear, and feasibility optimization scenario. The results show that the GOMORS outperforms the NSGA-II vastly regarding the number of function calls and Pareto-efficient results without the feasibility constraint. The problem is reformulated to an unconstrained, three-objective optimization problem to analyze the influence of the constraint. The constrained and unconstrained approaches show equal performance for the given scenarios. Accordingly, the authors provide a clear recommendation towards the surrogate-based GOMORS for costly and multi-objective evaluations. Furthermore, the algorithm can handle the feasibility constraint properly when formulated as an objective function and as a constraint.
LEST WE MISS IT: ANXIETY AND DEPRESSION SYMPTOMS IN ADULT PATIENTS WITH GENERALIZED TONIC CLONIC SEIZURES IN PAKISTAN

Objective: To find out the frequency of and compare anxiety and depression in epileptic and non-epileptic matched individuals. Methodology: This cross sectional study was carried out at a tertiary care hospital in Pakistan including 200 epilepsy patients, visiting the department of medicine and psychiatry for follow-up. The second group consisted of 200 epilepsy free healthy matched individuals. Hospital anxiety and depression scale (HADS) was administered to assess participants’ anxiety and depression. Means, frequencies, and Chi-square were applied to analyze the collected data. Results: Epilepsy patients were more likely to have depression ( χ 2 = 33.56, p<.001) and anxiety ( χ 2 = 55.96, p<.001) as compared to the control group. Anxiety symptoms were found in 42%, while depression in 34% of the patients. This was further distributed into mild, moderate and severe symptoms. Being unmarried, belonging to a particular age group, full time employment and a lower educational level were related with the anxiety symptoms while particular age group, lower educational level and full time employment with symptoms of depression. Conclusion: The Generalized Tonic and Colonic Seizures (GTCS) epilepsy population has a significantly higher rate of comorbid anxiety and depression symptomatology.
Multipole-based Electrically Small Unidirectional Antenna with Exceptionally High Realized Gain

Electrically small, high-directivity antennas are in demand for a variety of current and future wireless applications. An electrically small directive antenna (ESDA) that requires only one specially-engineered port to excite a set of multipoles is demonstrated in this paper. Four 90° copper sectors are combined with additional structures and fed with a coaxial cable. Two resonant quadrupoles (equivalent to two pairs of resonant electric dipoles) and one magnetic dipole are excited. Both high radiation efficiency and good impedance matching are achieved. Theoretical calculations, numerical simulations, and experimental measurements are shown to be in good agreement. An optimized prototype is designed, fabricated, and tested. The measured results confirm that it is a supergain system. The unidirectional ESDA has a peak directivity of 6.71 dBi, a peak realized gain of 6.31 dBi, a radiation efficiency of 94.5%, and a front-to-back ratio of 14.89 dB at its resonance frequency, 814 MHz. Its height is 0.06 λres and ka = 0.98. These measured realized gain and directivity values exceed both the Harrington and Kildal-Best ka-based upper limits.
Effects of Various Polymeric Films on the Pericarp Microstructure and Storability of Longan (cv. Shixia) Fruit Treated with Propyl Disulfide Essential Oil from the Neem (Azadirachta indica) Plant

Plant extracts represent a rich repository of metabolites with antioxidant and antimicrobial properties. Neem (Azadirachta indica) is a medicinal plant considered the tree of the 21st century. In this study, we investigated the antioxidant and antimicrobial effects of propyl disulfide (PD), a major volatile compound in neem seed, against the pericarp browning (BI), microbial decay incidence (DI), and water loss of longan fruit. Fresh longan cv. Shixia samples were packaged in oriented polypropylene (OPP) and polyethene (PE) packages of different thicknesses (20, 40, and 60 µm). Sterile gauze was fixed inside the packages and 500 uL of PD was placed on them to avoid the direct contact of PD with fruit samples. Packages were sealed immediately to minimize vaporization and stored at 12 ± 1 °C for 18 days. Fruit samples packaged in open net packages served as controls. The results showed that fruit treated with PD in OPP and PE packages significantly prevented losses of water, DI, and BI compared to control treatment. PD also maintained the color, TSS values, TA values, pH values, high peel firmness, high TPC content, and high TFC content, and reduced the activity levels of PPO and POD. Scanning electron microscope (SEM) analysis indicated that the exocarp, mesocarp, and endocarp of longan peel were smooth, uniform, and compact with no free space compared to control, where crakes, a damaged and loose structure, and a lot of fungal mycelia were found. The shortest shelf life of 9 days was observed in control as compared to 18 days in OPP-20 and OPP-40; 15 days in OPP-60, PE-20, and PE-40; and 12 days in PE-60 packaging films. Therefore, PD as a natural antioxidant and antimicrobial agent, in combination with OPP-20 and OPP-40 polymeric films, could successfully be applied commercially to extend the postharvest shelf life of longan.
Selected factors determining the failure to undertake physical activity in patients with multiple sclerosis in Poland

Background: The main aim of the study was to identify selected factors that determine patients with multiple sclerosis (MS’) failure to take home therapeutic exercises (HTE) and other physical activity (OPA). Materials and Methods: The study was conducted using a self-completed online survey that was aimed at adult people diagnosed with MS, registered on the portal TacyJakJa.pl. In total, 335 persons were involved. Results: Almost half of all people who completed the survey (49.9%), reported that no one encouraged them to use HTE, and only 16.1% were encouraged by their doctor. As many as 51% of the respondents reported also that no one encouraged them to undertake OPA, and only 18.5% were encouraged by their doctor. As the most important reason for not using HTE, the respondents chose fear that exercises may worsen their condition (47.3%). However, the most important reason for not using the OPA was high fatigue (61.9%). The number of people exercising at home increased with age (P = 0.013). Those surveyed with relapsing–remitting MS significantly more often (P = 0.002) took up OPA (60.7%) than the respondents with a secondary progressive MS (10.0%) and a primary progressive (4.4%). Conclusion: Physicians relatively rarely encourage patients with MS to undertake HTE and OPA. The patients do not perform HTE primarily because of fears of health deterioration or fatigue. Undertaking HTE is influenced by age but undertaking other forms of physical activity by the type of MS. Actions should be taken to popularize HTE and OPA, especially HTE among young patients.
Transcriptomic Analysis Reveals Functional Interaction of mRNA–lncRNA–miRNA in Steroidogenesis and Spermatogenesis of Gynogenetic Japanese Flounder (Paralichthys olivaceus)

Simple Summary Japanese flounder (Paralichthys olivaceus) is an important marine cultured fish that has a male heterogametic sex determination and shows significant sexual dimorphism with bigger females. Therefore, gynogenesis has presented great potential in breeding of all-female P. olivaceus. Non-coding RNAs are emerging as critical regulators of reproduction, and in this study, lncRNA–miRNA–mRNA interactions were investigated using high-throughput sequencing to reveal their roles in gynogenetic female and sex-reversed neo-male P. olivaceus. A considerable amount of steroidogenesis and spermatogenesis-related genes and ncRNAs were found, which may be regulated by let-7/miR-125b clusters and have significant functions during spermatogenesis of the neo-male P. olivaceus. These highly conserved and putatively interacted RNAs could replenish the genomic information of P. olivaceus and pave the way to understand the molecular mechanisms of gynogenesis effect and sex reversal in sexual development and gametogenesis of teleost fishes. Abstract Teleost fishes exhibit extraordinary diversity, plasticity and adaptability with their sex determination and sexual development, and there is growing evidence that non-coding RNAs (ncRNAs) are emerging as critical regulators of reproduction. Japanese flounder (Paralichthys olivaceus) is an important marine cultured fish that presents significant sexual dimorphism with bigger females, in which gynogenesis has been applied for aquaculture industry. In order to reveal the regulatory mechanisms of sexual development in gynogenetic female and sex-reversed neo-male P. olivaceus, the lncRNA–miRNA–mRNA interactions were investigated using high-throughput sequencing. A total of 6772 differentially expressed mRNAs (DEmRNAs), 2284 DElncRNAs, and 244 DEmiRNAs were obtained between gynogenetic female ovaries and sex-reversed neo-male testes. Genes in the steroid hormone biosynthesis and secretion pathway were enriched and mostly significantly upregulated in neo-male testes. Subsequently, network analysis uncovered high functional specificity for gynogenetic P. olivaceus sperm motility, as co-expressed DEmRNAs were significantly enriched in microtubule and cytoskeleton-related biological processes. Clustered miRNAs were characterized in the P. olivaceus genome with examples of the largest conserved let-7 clusters. The 20 let-7 members are distributed in 11 clusters and may not transcribe together with their neighboring miR-125b, with let-7 repressing cyp11a and miR-125b repressing esr2b, both as key steroidogenesis pathway genes. In summary, this study provides comprehensive insights into the mRNA–miRNA–lncRNA functional crosstalk in teleost sexual development and gametogenesis and will expand our understanding of ncRNA biology in teleost gynogenesis.
Depletion of Homeostatic Antibodies against Malondialdehyde-Modified Low-Density Lipoprotein Correlates with Adverse Events in Major Vascular Surgery

We aimed to investigate if major vascular surgery induces LDL oxidation, and whether circulating antibodies against malondialdehyde-modified LDL (MDA-LDL) alter dynamically in this setting. We also questioned relationships between these biomarkers and post-operative cardiovascular events. Major surgery can induce an oxidative stress response. However, the role of the humoral immune system in clearance of oxidized LDL following such an insult is unknown. Plasma samples were obtained from a prospective cohort of 131 patients undergoing major non-cardiac vascular surgery, with samples obtained preoperatively and at 24- and 72 h postoperatively. Enzyme-linked immunoassays were developed to assess MDA-LDL-related antibodies and complexes. Adverse events were myocardial infarction (primary outcome), and a composite of unstable angina, stroke and all-cause mortality (secondary outcome). MDA-LDL significantly increased at 24 h post-operatively (p < 0.0001). Conversely, levels of IgG and IgM anti-MDA-LDL, as well as IgG/IgM-MDA-LDL complexes and total IgG/IgM, were significantly lower at 24 h (each p < 0.0001). A smaller decrease in IgG anti-MDA-LDL related to combined clinical adverse events in a post hoc analysis, withstanding adjustment for age, sex, and total IgG (OR 0.13, 95% CI [0.03–0.5], p < 0.001; p value for trend <0.001). Major vascular surgery resulted in an increase in plasma MDA-LDL, in parallel with a decrease in antibody/complex levels, likely due to antibody binding and subsequent removal from the circulation. Our study provides novel insight into the role of the immune system during the oxidative stress of major surgery, and suggests a homeostatic clearance role for IgG antibodies, with greater reduction relating to downstream adverse events.