Miracle-dz/UniFAR-FTUs huggingface dataset:
Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy

Cisplatin has been described as a potent anticancer agent for decades. However, in the case of glioblastomas, it is only considered a rescue treatment applied after the failure of second-line treatments. Herein, based on the versatility offered by coordination chemistry, we engineered nanoparticles by reaction of a platinum (IV) prodrug and iron metal ions showing in vitro dual pH- and redox-sensitivity, controlled release and comparable cytotoxicity to cisplatin against HeLa and GL261 cells. In vivo intranasal administration in orthotopic preclinical GL261 glioblastoma tumor-bearing mice demonstrated increased accumulation of platinum in tumors, leading in some cases to complete cure and prolonged survival of the tested cohort. This was corroborated by a magnetic resonance imaging follow-up, thus opening new opportunities for intranasal glioblastoma therapies while minimizing side effects. The findings derived from this research showed the potentiality of this approach as a novel therapy for glioblastoma treatment.
The Impact of Mobile Learning on the Effectiveness of English Teaching and Learning—A Meta-Analysis

Mobile devices have been widely used in both teaching and learning English as a second or foreign language. The impact of using various mobile devices on the learning outcome has thus been subject to an increasing number of educational experiments. However, the results of these experiments have not always been consistent or conclusive. In order to evaluate the effectiveness of mobile learning, it is necessary to employ a meta-analysis approach to synthesize results taken from previous experiments. This study examined 29 experiments, including both true and quasi, on the learning outcome of those learners who used mobile devices in their English learning process. Following $PRISMA$ guidelines for conducting meta-analysis, this study has found that mobile learning has a highly positive effect on English learning outcomes with a weighted effect size of 0.893. The effect of mobile learning is subject to potential moderating variables, such as learners’ levels, intervention time, language learning areas being targeted, hardware and software, and implementation setting. Taken as a whole, the results indicate that mobile learning is affording a change in English learning that does not undermine pre-existing models of English language pedagogy. Therefore, progressive exploration and implementation of mobile learning effectiveness appears to be of some importance to English teaching and learning stakeholders.
Multiparametric Magnetic Resonance Imaging Grades the Aggressiveness of Prostate Cancer

Simple Summary Prostate cancer (PCa) aggressiveness can be assessed from clinical and pathologic surrogate endpoints as the International Society of Uropathology grade group (GG) in prostate biopsies, the type of pathology from surgical specimens, the clinical stage, and the risk of biochemical recurrence after treatment of localised PCa. Low evidence exists about the association between prostate magnetic resonance imaging (MRI) and PCa aggressiveness beyond the known increased risk of clinically significant PCa (csPCa) as Prostate Imaging and Data Report System (PI-RADS) increase. Therefore, we confirm previous data and generate new evidence from all the previous surrogate endpoints of PCa aggressiveness, confirming that MRI grades the aggressiveness of PCa. Abstract We sought to find further evidence showing the increase in PCa aggressiveness as PI-RADS score increases from four surrogates of PCa aggressiveness: i. prostate biopsy GG (≤3 vs. >3), ii. type of pathology in surgical specimens (favourable vs. unfavourable), iii. clinical stage (localised vs. advanced), and risk of recurrence of localised PCa after primary treatment (low-intermediate vs. high). A group of 692 PCa patients were diagnosed after 3-T multiparametric MRI (mpMRI) and guided and/or systematic biopsies, showing csPCa (GG ≥ 2) in 547 patients (79%) and insignificant PCa (iPCa) in 145 (21%). The csPCa rate increased from 32.4% in PI-RADS < 3 to 95.5% in PI-RADS 5 (p < 0.001). GG ≥ 3 was observed in 7.6% of PCa with PI-RADS < 3 and 32.6% in those with PI-RADS > 3 (p < 0.001). Unfavourable pathology was observed in 38.9% of PCa with PI-RAD < 3 and 68.3% in those with PI-RADS > 3 (p = 0.030). Advanced disease was not observed in PCa with PI-RADS ≤ 3, while it existed in 12.7% of those with PI-RADS > 3 (p < 0.001). High-risk recurrence localised PCa was observed in 9.5% of PCa with PI-RADS < 3 and 35% in those with PI-RADS > 3 (p = 0.001). The PI-RADS score was an independent predictor of all surrogates of PCa aggressiveness as PSA density. We confirmed that mpMRI grades PCa aggressiveness.
Electrografting a Hybrid Bilayer Membrane via Diazonium Chemistry for Electrochemical Impedance Spectroscopy of Amyloid-β Aggregation

Herein, a novel hybrid bilayer membrane is introduced as a platform to study the aggregation of amyloid-β1–42 (Aβ1–42) peptide on surfaces. The first layer was covalently attached to a glassy carbon electrode (GCE) via diazonium electrodeposition, which provided a highly stable template for the hybrid bilayer formation. To prepare the long-chain hybrid bilayer membrane (lcHBLM)-modified electrodes, GCE surfaces were modified with 4-dodecylbenzenediazonium (DDAN) followed by the modification with dihexadecyl phosphate (DHP) as the second layer. For the preparation of short-chain hybrid bilayer membrane (scHBLM)-modified electrodes, GCE surfaces were modified with 4-ethyldiazonium (EDAN) as the first layer and bis(2-ethylhexyl) phosphate (BEHP) was utilized as the second layer. X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) were used to characterize the bilayer formation. Both positively charged [Ru(NH3)6]3+ and negatively charged ([Fe(CN)6]3-/4-) redox probes were used for electrochemical characterization of the modified surfaces using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). EIS results showed a decrease in charge transfer resistance (Rct) upon incubation of Aβ1–42 on the hybrid bilayer-modified surfaces. This framework provides a promising electrochemical platform for designing hybrid bilayers with various physicochemical properties to study the interaction of membrane-bound receptors and biomolecules on surfaces.
Microbially Induced Anaerobic Oxidation of Magnetite to Maghemite in a Hydrocarbon‐Contaminated Aquifer

Iron mineral transformations occurring in hydrocarbon‐contaminated sites are linked to the biodegradation of the hydrocarbons. At a hydrocarbon‐contaminated site near Bemidji, Minnesota, USA, measurements of magnetic susceptibility (MS) are useful for monitoring the natural attenuation of hydrocarbons related to iron cycling. However, a transient MS, previously observed at the site, remains poorly understood and the iron mineral phases acting as reactants and products associated with this MS perturbation remain largely unknown. To address these unknowns, we acquired mineral magnetism measurements, including hysteresis loops, backfield curves, and isothermal remanent magnetizations on sediment core samples retrieved from the site and magnetite‐filled mineral packets installed within the aquifer. Our data show that the core samples and magnetite packs display decreasing magnetization with time and that this loss in magnetization is accompanied by increasing bulk coercivity consistent with decreased average grain size and/or partial oxidation. Low‐temperature magnetometry on all samples displayed behavior consistent with magnetite, but samples within the plume also show evidence of maghemitization. This interpretation is supported by the occurrence of shrinkage cracks on the surface of the grains imaged via scanning electron microscopy. Magnetite transformation to maghemite typically occurs under oxic conditions, here, we propose that maghemitization occurs within the anoxic portions of the plume via microbially mediated anaerobic oxidation. Mineral dissolution also occurs within the plume. Microorganisms capable of such anaerobic oxidation have been identified within other areas at the Bemidji site, but additional microbiological studies are needed to link specific anaerobic iron oxidizers with this loss of magnetization.
Community Fecal Carriage and Molecular Epidemiology of Extended-Spectrum β-Lactamase- and Carbapenemase-Producing Escherichia coli from Healthy Children in the Central South China

Background Fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) and carbapenemase-producing E. coli (CP-EC) is well reported among hospitalized adults and children. However, there are few studies on the carriage prevalence and ESBL-EC and CP-EC genotypes among healthy children in China. Patients and Methods Stool samples were collected from 330 students in 2021 from three randomly selected primary schools in Changsha, China. ESBL-EC and CP-EC were screened using CHROMagarTM chromogenic plates. ESBL and carbapenemase production was confirmed using the double-disc synergy test and a modified carbapenem inactivation method, respectively. Antimicrobial susceptibility was tested using the broth microdilution method. Resistance determinants, virulence factors, and phylogenetic groups were determined by PCR and sequencing. Multi-locus sequence typing (MLST) was performed (seven housekeeping genes were amplified and sequenced) on the phylogenic group B2 E. coli to detect high-risk clonal strains such as ST131 E. coli. Then, ST131 E. coli were characterized based on ST131 clades, O-type, and fimH alleles. Results In total, 118 (35.8%) ESBL-EC and 3 (0.9%) CP-EC were isolated. blaCTX-M was the most common genotype (27.1%), identified in all ESBL-EC, except one, which carried blaSHV-12. One isolate with mcr-1 was found amongst ESBL-EC, whereas all three CP-EC carried blaNDM-1. The predominant sequence type (ST) clones in group B2 were ST131 and ST1193. The prevalence of ST131 E. coli was 9.9%, displaying serotypes O16 and O25b, fimH alleles 30, 41, and 89, and ST131 clades A and C1-M27. Conclusion In this study, high carriage rate of ESBL-EC was found among healthy children, and the dominant ESBL was CTX-M-14. In addition, high-risk clones (ST131 and ST1193) were also detected. This emphasizes the importance of monitoring ESBL-EC in community settings.
Monte Carlo simulation of electron heating in scaled deep submicron MOSFETs

The effects of device scaling on electron heating and intrinsic device performance in deep submicron n-MOSFETs are investigated by means of a Monte Carlo device simulator featuring an original model for electron transport at high electric fields. It is shown that linear voltage scaling is too conservative for future deep submicron technologies, at least from the point of view of electron heating; in fact, weaker supply reductions (for example, designed for constant maximum lateral electric field) provide better device performance with no increase of hot electron effects. <<ETX>>
Who will Win the Data Science Competition? Insights from KDD Cup 2019 and Beyond

Data science competitions are becoming increasingly popular for enterprises collecting advanced innovative solutions and allowing contestants to sharpen their data science skills. Most existing studies about data science competitions have a focus on improving task-specific data science techniques, such as algorithm design and parameter tuning. However, little effort has been made to understand the data science competition itself. To this end, in this article, we shed light on the team’s competition performance, and investigate the team’s evolving performance in the crowd-sourcing competitive innovation context. Specifically, we first acquire and construct multi-sourced datasets of various data science competitions, including the KDD Cup 2019 machine learning competition and beyond. Then, we conduct an empirical analysis to identify and quantify a rich set of features that are significantly correlated with teams’ future performances. By leveraging team’s rank as a proxy, we observe “the stronger, the stronger” rule; that is, top-ranked teams tend to keep their advantages and dominate weaker teams for the rest of the competition. Our results also confirm that teams with diversified backgrounds tend to achieve better performances. After that, we formulate the team’s future rank prediction problem and propose the Multi-Task Representation Learning (MTRL) framework to model both static features and dynamic features. Extensive experimental results on four real-world data science competitions demonstrate the team’s future performance can be well predicted by using MTRL. Finally, we envision our study will not only help competition organizers to understand the competition in a better way, but also provide strategic implications to contestants, such as guiding the team formation and designing the submission strategy.
Parallel 3D Finite Element Particle-In-Cell Code for High-Fidelity RF Gun Simulations

SLAC’s Advanced Computations Department (ACD) has developed the first high-performance parallel Finite Element 3D Particle-In-Cell code, Pic3P, for simulations of RF guns and other space-charge dominated beam-cavity interactions. As opposed to standard beam transport codes, which are based on the electrostatic approximation, Pic3P solves the complete set of Maxwell-Lorentz equations and thus includes space charge, retardation and wakefield effects from first principles. Pic3P uses advanced Finite Element methods with unstructured meshes, higher-order basis functions and quadratic surface approximation. A novel scheme for causal adaptive refinement reduces computational resource requirements by orders of magnitude. Pic3P is optimized for large-scale parallel processing and allows simulations of realistic 3D particle distributions with unprecedented accuracy, aiding the design and operation of the next generation of accelerator facilities. Applications to the Linac Coherent Light Source (LCLS) RF gun are presented.
Hydroclimatic Conditions, Wildfire, and Species Assemblages Influence Co-Occurrence of Bull Trout and Tailed Frogs in Northern Rocky Mountain Streams

Although bull trout (Salvelinus confluentus) and tailed frogs (Ascaphus montanus) have co-existed in forested Pacific Northwest streams for millennia, these iconic cold-water specialists are experiencing rapid environmental change caused by a warming climate and enhanced wildfire activity. Our goal was to inform future conservation by examining the habitat associations of each species and conditions that facilitate co-occupancy. We repurposed data from previous studies in the northern Rocky Mountains to assess the efficacy of bull trout electrofishing surveys for determining the occurrence of tailed frogs and the predictive capacity of habitat covariates derived from in-stream measurements and geospatial sources to model distributions of both species. Electrofishing reliably detected frog presence (89.2% rate). Both species were strongly associated with stream temperature and flow regime characteristics, and less responsive to riparian canopy cover, slope, and other salmonids. Tailed frogs were also sensitive to wildfire, with occupancy probability peaking around 80 years after a fire. Co-occupancy was most probable in locations with low-to-moderate frequencies of high winter flow events, few other salmonids, a low base-flow index, and intermediate years since fire. The distributions of these species appear to be sensitive to environmental conditions that are changing this century in forests of the northern Rocky Mountains. The amplification of climate-driven effects after wildfire may prove to be particularly problematic in the future. Habitat differences between these two species, considered to be headwater specialists, suggest that conservation measures designed for one may not fully protect the other. Additional studies involving future climate and wildfire scenarios are needed to assess broader conservation strategies and the potential to identify refuge streams where both species are likely to persist, or complementary streams where each could exist separately into the future.
Impact of Grazing on Diversity of Semi-Arid Rangelands in Crete Island in the Context of Climatic Change

The rangelands of Crete island (Greece) are typical Mediterranean habitats under high risk of degradation due to long-term grazing and harsh climatic conditions. We explored the effect of abiotic (climatic conditions, altitude) and biotic factors (long-term grazing by small ruminants) on the floristic composition and diversity of selected lowland (Pyrathi, Faistos) and highland (Vroulidia, Nida) rangelands. In each rangeland, the ground cover was measured, and the floristic composition was calculated in terms of five functional groups: grasses, legumes, forbs, phrygana, and shrubs. The aridity index, species turnover, species richness, Shannon entropy, and Gini–Simpson index (with the latter two converted to the effective number of species) were calculated. Our results reveal that highlands are characterized by the highest aridity index (wetter conditions). Lowland rangelands, compared to highland, exhibited a higher percentage contribution of grasses, legumes, and forbs, while species turnover decreased along the altitudinal gradient. The Shannon entropy index was correlated (a) positively with Gini–Simpson and mean annual temperature and (b) negatively with mean annual precipitation, aridity index, and altitude. Moreover, the Gini–Simpson index correlated positively with mean annual temperature and negatively with altitude. Our results could help to understand the effects of grazing on rangeland dynamics and sustainability in semi-arid regions in the context of climatic change.
Systems Analysis and Solid Waste Planning

Increasing waste generation, difficulties in labor-management relations, rising costs, and uncertain technology are only a few of the problems facing today's solid waste managers. A number of analytical tools, including management information systems, simulation, and mathematical models, are available and can be applied to the solution of these and related problems. This paper presents various system analysis approaches which have been used to analyze the solid waste management function and reports on the development of a management information system combined with a simulation model that has been implemented in a large metropolitan area. As a result of this project, the city made substantial changes in its solid waste application saving over $9,000,000 in 2 yr.
Impact of TNFAIP3 Genetic Polymorphisms on Primary Immune Thrombocytopenia in Egyptian Adults: Case-control Study

BACKGROUND: Immune Thrombocytopenia (ITP) is a common acquired hematological disease. Genetic polymorphisms play an important role in ITP pathogenesis and prognosis. TNF-α-induced protein 3 (TNFAIP3) is a negative regulator of NF-kB in many signaling pathways. Several variants of TNFAIP3 have been associated with various inflammatory autoimmune disorders. AIM: Our study aimed to study the association of TNFAIP3 single nucleotide polymorphisms (SNPs); rs2230926 & rs5029939 with ITP susceptibility, as well ITP prognosis by follow up the cases for 18 months. METHODS: One hundred and ten ITP patients as well 110 matched unrelated normal controls were enrolled in our study. The polymorphisms were assessed by real-time polymerase chain reaction (real time PCR). RESULTS: There were a significant difference between cases and control groups regarding rs2230926 T>G and rs5029939 C>G frequencies with p < 0.05. Linkage disequilibrium (LD) analysis of the two variants revealed that there was a significant LD (p < 0.001). Non-cutaneous bleeding manifestations were observed mainly in the mutant genotypes of rs2230926 and rs5029939. The ITP patients with mutant genotypes of rs5029939 showed more need to use 2nd line immunosuppressive therapy as well the mutant genotypes of rs2230926 showed more steroid dependence and less complete recovery. CONCLUSION: Our data concluded the presence of LD between rs5029939 and rs2230926. The mutant genotypes of both variants were associated with increase the susceptibility to ITP and accompanied by worse clinical manifestations and poor response to the treatment in the adult Egyptian patients.
Continuing Down the Road to Reintegration: Status and Ongoing Support of the U.S. Air Force’s Wounded Warriors

The U.S. Air Force (AF) wanted to gauge the current status of its wounded warriors, including their use of and satisfaction with AF programs designed to serve them. The research team surveyed AF wounded warriors (wave 1) and published the results in 2015. This report presents the analysis of the second such survey, called wave 2.
Insect Abundance and Diversity Respond Favorably to Vegetation Communities on Interim Reclamation Sites in a Semi-Arid Natural Gas Field

Natural resource extraction has been linked to habitat loss and declines in biodiversity. Insects, the most diverse and abundant animals on Earth, provide a wide array of critical ecosystem services, but are typically understudied in terrestrial restoration projects. Here, we examine how insects and other arthropods respond to reclamation efforts in the Pinedale Anticline natural gas field in semi-arid Wyoming, USA. Vegetation on two-year-old well pads seeded with native grass or one-year-old well pads seeded with a native annual forb, Rocky Mountain bee plant (Cleomeserrulata), was measured and compared to reference areas adjacent to the well pads with a free software program called SamplePoint. Reference areas in the Pinedale Anticline natural gas field consist primarily of decadent sagebrush stands with low floral diversity. Insect and arthropod communities were also collected and assessed for family richness and abundance on these well pads and reference areas over two years. Based on the mass flowering hypothesis, we expected higher insect abundance and diversity on well pads seeded with the Rocky Mountain bee plant compared to adjacent reference areas. Based on the plant vigor hypothesis, we expected higher insect abundance and diversity on well pads seeded with native grass than reference communities. In year one, 893 insects from 30 insect families with an additional 12 arthropods from 4 families were captured. In year two, 685 insects from 17 families were collected. Reclaimed well pads had significantly higher abundance in both years and vegetation types. In year one, we did not detect a significant difference in richness on native-grass-treated well pads vs. the reference site. We found a significant difference in richness on bee-plant-treated well pads vs. the reference in both years, as well as native-grass-treated well pads vs. the reference in year two. Implications of these findings are discussed in the manuscript.
Studying magnetic-polaron cooper-pair-breaking effects in Bi2Sr2CaCu2O8+δ by femtosecond photoexcitation

The relation between magnetism and superconductivity, whether magnetism is beneficial to superconductivity or they permit co-existence and competition, has been a long debate in the high-temperature superconducting field. Here, to explore this odd issue, we study the relaxation dynamics of photoinduced magnetic-polaron and superconductivity quasiparticles by an ultrafast time-resolved optical reflectivity technology in Bi2Sr2CaCu2O8+δ . When the pump fluence F is less than 7 mW, time-resolved reflection spectrum ΔR(t)/R 0 is dominated by the superconducting component. It is noteworthy that a large of photoinduced magnetic-polaron component can cause the inhibition of the superconducting component when the variable pump fluence F is more than the value 7 mW. It can be attributed to the strong photoinduced magnetic-polaron Cooper-pair-breaking mechanism. Further studies have shown that the photoinduced magnetic-polaron Cooper-pair-breaking mechanism is similar to the pair-breaking effect caused by the magnetic impurity Fe in the Bi2Sr2CaCu2O8+δ superconductor, although the forms of their action are different.