Miracle-dz/UniFAR-FTUs huggingface dataset:
No Control, No Consumption: Association of Low Perceived Control and Intention to Accept Genetically Modified Food

Based on compensatory control theory, the aim of this study was to examine the effects of perceived control on people’s acceptance of genetically modified (GM) foods by using both correlational and experimental methods. Compensatory control theory proposes that the lower an individual’s perceived control, the higher their need for structure, order, and certainty. Therefore, based on beliefs about GM foods that make some people less certain that those foods are as safe as traditional foods, we hypothesized that individuals with lower levels of perceived control are more inclined to reject GM foods. The analysis of questionnaire responses in Study 1 revealed that individuals’ sense of control negatively predicted their risk perception of GM foods, while the need for structure played a mediating role. In Study 2, using a between-subject design, we manipulated participants’ perceived control (higher vs. lower) and subsequently measured their risk perception and purchasing preferences for GM foods. The results in Study 2 show that under lower control conditions, individuals recognize higher risks related to GM foods, which, in turn, decreases their willingness to purchase GM foods. These results not only suggest that perceived control is a potential influential personal factor of the acceptance of GM foods but also extend the scope of the application of compensatory control theory.
Paradiospyroxylon kvacekii gen. et sp. nov. from the Paleogene of the Czech Republic: a case study of individual variability and its significance for fossil wood systematics

ABSTRACT The wood anatomy of Paradiospyroxylon kvacekii gen. et sp. nov. is described and illustrated based on material originating from the Ústí Formation’s volcanic deposits of České středohoří Mts. (Paleogene, Czech Republic). The sample, identified earlier as Manilkaroxylon sp. , was critically examined and is interpreted as root wood and proposed as the paratype of Paradiospyroxylon kvacekii. This paper discusses how wood anatomical variation needs to be considered when making systematic and palaeoecological interpretations.
Effects of Melatonin on Sleep Quality and Disease Activity in Patients With Rheumatoid Arthritis

Background and Objective In rheumatoid arthritis (RA) patients sleep disturbance is one of serious and prevalent problems. Considering the known effects of melatonin on sleep quality and inflammation, this study aimed to investigate melatonin supplementation effect on quality of sleep and disease activity in patients with RA.Methods In this randomized, placebo-controlled trial (double-blind), 64 RA patients were selected and divided into experimental and placebo groups randomly; experimental group received 3 mg/d of melatonin and another group consumed placebo for 60 days. Before and after the investigation, assessment of the quality of sleep determined using the Pittsburgh Sleep Quality Index (PSQI). Disease Activity Score-28 (DAS28) and the Visual Analogue Scale (VAS) questionnaires were used for evaluation of disease activity and pain intensity, respectively.Results Melatonin significantly reduced PSQI, DAS28 and VAS scores, when values compared with baseline. In contrast to placebo group, good sleep quality within the melatonin group increased significantly compared to baseline and this improvement in sleep quality was significant when compared between groups. The scores of DAS28 and pain VAS at the end of trial were significantly reduced compared to the baseline in both groups. However, reduction in the DAS28 and VAS scores of the melatonin group were stronger than reductions in the placebo receiving group.Conclusions This study results revealed that melatonin was safe and effective in improving sleep quality and reducing DAS28 and pain VAS scores in RA patients.
The Influence of Principal Transformational Leadership, Work Ethic, through Organizational Commitment to the Performance of State Middle School Teachers in Hulu Sungai Tengah District

This study aims to describe and analyze the direct and indirect effects of the variables: principal's transformational leadership, work ethic, organizational commitment, and teacher performance at State Junior High Schools in Hulu Sungai Tengah. This study uses a quantitative approach. The population in this study was 519 people. The sampling technique used was proportional random sampling determined by Alpha Cronbach with a sample of 226 teachers. Data was collected using instruments consisting of transformational leadership (48 items), work ethic (35 items), and teacher performance (based on the results of PKG) which have been tested for validity and reliability. The research data were analyzed using path analysis. The study results found that there was a direct influence of the principal's transformational leadership on teacher performance and organizational commitment. Moreover, a teacher's work ethic directly influences teacher performance and organizational commitment. Then, there was a direct influence of organizational commitment on teacher performance. The indirect effect of principal transformational leadership was analyzed through an organizational commitment to teacher performance and teacher work ethic through an organizational commitment to teacher performance.
Specific Cerebrospinal Fluid SerpinA1 Isoform Pattern in Alzheimer’s Disease

SerpinA1 (α1-antitrypsin) is a soluble glycoprotein, the cerebrospinal fluid (CSF) isoforms of which showed disease-specific changes in neurodegenerative disorders that are still unexplored in Alz-heimer’s disease (AD). By means of capillary isoelectric focusing immunoassay, we investigated six serpinA1 isoforms in CSF samples of controls (n = 29), AD-MCI (n = 29), AD-dem (n = 26) and Lewy body disease (LBD, n = 59) patients and correlated the findings with CSF AD core biomarkers (Aβ42/40 ratio, p-tau, t-tau). Four CSF serpinA1 isoforms were differently expressed in AD patients compared to controls and LBD patients, especially isoforms 2 and 4. AD-specific changes were found since the MCI stage and significantly correlated with decreased Aβ42/40 (p < 0.05) and in-creased p-tau and t-tau levels in CSF (p < 0.001). Analysis of serpinA1 isoform provided good di-agnostic accuracy in discriminating AD patients versus controls (AUC = 0.80) and versus LBD patients (AUC = 0.92), with best results in patients in the dementia stage (AUC = 0.97). SerpinA1 isoform expression is altered in AD patients, suggesting a common, albeit disease-specific, in-volvement of serpinA1 in most neurodegenerative disorders.
Effect of monetite reinforced into the chitosan-based lyophilized 3D scaffolds on physicochemical, mechanical, and osteogenic properties

Abstract Chitosan and monetite nanoparticles-based composite scaffold with tailored structures and properties possesses tremendous potential for bone restoration. Here, we aimed to enhance the physicochemical, mechanical, and biological properties of a three-dimensional composite scaffold by the addition of monetite nanoparticles into a chitosan matrix with varying content of monetite in the developed scaffolds. The scaffolds were fabricated from the viscous slurry containing chitosan and nano monetite particles using a free-drying process. Macro-porous scaffolds were fabricated by incorporation of nano-sized monetite particles up to 20 wt% of total chitosan concentration into pure chitosan solution. These are then characterized using an X-ray diffractometer (XRD), FTIR, and field emission electron microscope (FESEM). Results revealed that the chitosan/monetite composite scaffolds showed highly porous architecture with an average pore size varying between 90 and 390 µm, and high interconnected porosity varying from 77 to 88%, respectively. Scaffold containing 20 wt% monetite (CS-M20) revealed the highest compressive strength of 1.93 MPa, which is closely matching with that of the lower range of compressive strength in cancellous bone. The incorporation of monetite content into the chitosan matrix significantly diminished (p < 0.05) pore size, and porosity and retarded the rate of biodegradation of the monetite-containing scaffolds as evident from 20 wt% and 38 wt% of weight loss in CSM20 and CSM10 scaffolds after 28 days of incubation in a sterile PBS. Monetite-containing scaffolds showed a higher ability of mineralization as compared to the pristine chitosan (CS-M0) scaffold, depositing bone-like carbonated hydroxyapatite crystals onto their surface after 14 days of immersion in SBF at 37 °C. A higher extent of lamellipodia and filopodia protrusions and superior spreading behavior of osteoblasts were noticed in FESEM images of MG-63 cultured monetite containing scaffolds. MTT assay exhibited significantly higher (p < 0.05) MG-63 cell proliferation in monetite-containing CS-M20 scaffold than that in pristine chitosan scaffold suggesting the fact that monetite nanoparticles incorporation into the chitosan matrix stimulated superior osteoblast attachment and proliferation. Further, immunocytochemistry analysis of MG-63 cultured onto developed scaffolds revealed higher osteogenic activity and differentiation ability in CS-M20 scaffold as compared to pristine chitosan scaffold. The obtained results demonstrated that the monetite-containing scaffolds have a great potential for the regeneration of bone tissue defects. Graphical Abstract
Investigations into Salmonella Contamination in Feed Mills Producing Rations for the Broiler Industry in Great Britain

Feed-associated Salmonella serovars continue to be reported in poultry flocks. A study was conducted to investigate Salmonella contamination in major commercial feed mills that produce rations for broiler chickens within Great Britain. Dust and large moist gauze swab samples (12,791) were collected from 22 feed mills on 31 visits. Salmonella was isolated from 20 mills, with 15 mills (75%) having fewer than 5% Salmonella-positive samples. Fifty-one Salmonella serovars were isolated, with a large proportion of isolates being Salmonella (S.) Kedougou (29.4%) or S. 13,23:i:- (21.4%). European Union-regulated Salmonella serovars (Enteritidis, Infantis, Typhimurium and its monophasic variants) were isolated from 12 mills, mostly from non-processing areas, accounting for 40 isolates (4.4% of all Salmonella-positive samples). Fifteen Salmonella serovars were only isolated once. In terms of individual sampling locations within the mill, the waste handling locations were significantly more likely to be Salmonella-positive than some other mill locations. When sampling locations were grouped, samples collected from finished product areas were significantly less likely to be Salmonella-positive for Salmonella than some other mill areas. In conclusion, this study found that most mills producing broiler rations showed low-level Salmonella contamination.
Case Report: Opioid Use Disorder Associated With Low/Moderate Dose of Loperamide in an Intellectual Disability Patient With CYP3A and P-Glycoprotein Reduced Activity

Loperamide is an over-the-counter antidiarrheal for which increasing cases of abuse or misuse are described. We report the onset of opioid use disorder associated with low to moderate doses of loperamide in an intellectual disability patient without previous history of substance use disorder (SUD). Our patient presented strongly reduced activities of CYP3A and P-glycoprotein, which are mainly involved in loperamide metabolism and transport. We suggest that this led to an increase in bioavailability, systemic exposure, and brain penetration thus allowing loperamide to act on the central nervous system and contributing to the development of SUD. Slow release oral morphine (SROM) was chosen as opioid agonist treatment, which successfully contained loperamide use and globally improved her clinical condition. This situation highlights the need for caution and awareness when prescribing loperamide, particularly in vulnerable patients with few cognitive resources to understand the risks of self-medication and little insight into its effects.
Psychometric Properties of Intercultural Competences in a Central European Context

This study aims to validate Fantini’s intercultural competence scale in a sample of foreign students in a Central European context, and to figure out the pathways which are critical in improving the intercultural competence of foreign students. To achieve that, the study used confirmatory factor analysis (CFA) to construct the structural equation model (SEM). The results indicate that the scale is reliable and valid for assessing foreign students’ intercultural competence. In addition, using the first-order CFA as a baseline model, the SEM indicates that each intercultural knowledge, attitude, and skills are essential in predicting the intercultural awareness of the students. On the other hand, enhanced awareness plays an important role in promoting the development of these factors. Based on that, the study provides university decision-makers with valuable information which can be helpful in formulating related policies and rules aiming to enhance the integration and intercultural contact between foreign and Hungarian students at the university environment.
Performance Analysis of Joint Active User Detection and Channel Estimation for Massive Connectivity

This paper considers joint active user detection (AUD) and channel estimation (CE) for massive connectivity scenarios with sporadic traffic. The state-of-art method under a Bayesian framework to perform joint AUD and CE in such scenarios is approximate message passing (AMP). However, the existing theoretical analysis of AMP-based joint AUD and CE can only be performed with a given fixed point of the AMP state evolution function, lacking the analysis of AMP phase transition and Bayes-optimality. In this paper, we propose a novel theoretical framework to analyze the performance of the joint AUD and CE problem by adopting the replica method in the Bayes-optimal condition. Specifically, our analysis is based on a general channel model, which reduces to particular channel models in multiple typical MIMO communication scenarios. Our theoretical framework allows ones to measure the optimality and phase transition of AMP-based joint AUD and CE as well as to predict the corresponding performance metrics under our model. To reify our proposed theoretical framework, we analyze two typical scenarios from the massive random access literature, i.e., the isotropic channel scenario and the spatially correlated channel scenario. Accordingly, our performance analysis produces some novel results for both the isotropic Raleigh channel and the spatially correlated channel case.
Kadar 25(OH)D3 darah pada penderita obesitas

Blood level 25(OH)D3 in obese peopleBackground: Currently, obesity is a world problem, even the World Health Organization (WHO) declared obesity to be a global epidemic and contributes 5% of global deaths in 2015. Recently, many studies have reported an association between vitamin D levels and the incidence of obesity, although the exact mechanism raises many questions. Objective: This study is to examine the correlation between levels of 25(OH)D3 and body mass index (BMI). Methods: The design of this research is an analytic survey with a case control approach. The population of this study was all students of the Faculty of Medicine, Malahayati University, Bandar Lampung. The number of samples in this study were 60 samples with details of 30 case samples (obesity) and 30 control samples (no obesity). The sampling technique used was purposive sampling. The data used are primary data from direct measurement results. The data were analyzed using the correlation test.Results: The results showed that only one sample had normal 25(OH)D3 levels, while most (more than 98%) had low and very low levels of 25(OH)D3. The correlation test showed that there was a significant relationship between 25(OH)D3 levels with BMI (p=0.008; r= -0.0338), gender (p=0.001; r= -0.457), and total cholesterol levels (p=0.009); r= -0,391). Conclusions: There is a relationship between levels of 25(OH)D3 with BMI, the lower the 25(OH)3 blood level, the higher the risk of increasing BMI. Further research is still needed to ensure that giving vitamin D to obese populations can reduce body weight or BMI.
Long-Term Clinical Outcome in Systemic Lupus Erythematosus Patients Followed for More Than 20 Years: The Milan Systemic Lupus Erythematosus Consortium (SMiLE) Cohort

Tackling active disease to prevent damage accrual constitutes a major goal in the management of patients with systemic lupus erythematosus (SLE). Patients with early onset disease or in the early phase of the disease course are at increased risk of developing severe manifestations and subsequent damage accrual, while less is known about the course of the disease in the long term. To address this issue, we performed a multicentre retrospective observational study focused on patients living with SLE for at least 20 years and determined their disease status at 15 and 20 years after onset and at their last clinical evaluation. Disease activity was measured through the British Isles Lupus Assessment Group (BILAG) tool and late flares were defined as worsening in one or more BILAG domains after 20 years of disease. Remission was classified according to attainment of lupus low-disease-activity state (LLDAS) criteria or the Definitions Of Remission In SLE (DORIS) parameters. Damage was quantitated through the Systemic Lupus Erythematosus International Collaborating Clinics/American College of Rheumatology damage index (SLICC/ACR-DI). LLAS/DORIS remission prevalence steadily increased over time. In total, 84 patients had a late flare and 88 had late damage accrual. Lack of LLDAS/DORIS remission status at the 20 year timepoint (p = 0.0026 and p = 0.0337, respectively), prednisone dose ≥ 7.5 mg (p = 9.17 × 10−5) or active serology (either dsDNA binding, low complement or both; p = 0.001) were all associated with increased late flare risk. Late flares, in turn, heralded the development of late damage (p = 2.7 × 10−5). These data suggest that patients with longstanding SLE are frequently in remission but still at risk of disease flares and eventual damage accrual, suggesting the need for tailored monitoring and therapeutic approaches aiming at effective immunomodulation besides immunosuppression, at least by means of steroids.
Tough Love: Impact of High-Performance Work System on Employee Innovation Behavior

Based on the social exchange theory, this paper discusses the impact of high-performance work system (HPWS) on employee innovation behavior, constructs the mediating model of challenge stress and the moderated mediation model, and explores the influence mechanism of HPWS on employee innovation behavior under the management mode of combining strictness and love formed by “strictness” under the effect of challenge stress and “love” given by perceived organizational support. Through hierarchical regression analysis of 227 employees’ survey data, the results show that HPWS positively influences employee innovation behavior. Challenge stress partially mediates the above relationship, and perceived organizational support positively moderates the mediating effect of challenge stress between HPWS and employee innovation behavior.
Double-Edged Bullets: The Conditional Effect of Terrorism on Vote for the Incumbent

Abstract Terrorism often seeks to impact democratic politics. This article explores how it can influence the electoral fortunes of the incumbent. Existing research is contradictory. Models of retrospective voting predict a negative impact, as terrorism is detrimental to voters' welfare. However, the well-known ‘rally around the flag’ effect suggests otherwise: following a terrorist attack, voters often cling to the incumbent. We reconcile these arguments and argue that while both effects can coexist, the retrospective assessment is more durable than the rally around the flag. Using data on all deadly domestic terrorist attacks in Spain between 1977 and 2008, matched with municipal-level national election results, we show how exposure to strikes that occur during the last quarter of the term benefit the incumbent, while more temporally distant attacks are electorally harmful. In line with our theory, we find a more pronounced temporal heterogeneity for indiscriminate attacks and those that target civilians.
First-year experience of transitioning from registered nurse to nurse practitioner

ABSTRACT Background: Transitioning to advanced practice, novice nurse practitioners need to take on new roles, learn new practice areas, and develop new skills. This process requires breaking old practices and work habits and facing new challenges. Purpose: To explore the nature of nurse practitioners' work experiences during the first year of transition from registered nurse to nurse practitioner. Methods: This qualitative study was based on Husserl's phenomenological methodology. A purposive sample of 16 first-year nurse practitioners was recruited. Data were collected through in-depth interviews and analyzed by thematic content analysis. The approaches of Lincoln & Guba were applied to improve the validity of the study. Results: Results showed that the first-year experience of transitioning from registered nurse to nurse practitioner fell into two overarching themes: challenge and adjustment. The challenge consists of five subthemes: “facing the expectation-reality gap,” “managing others' expectations,” “striving to acquire professional skills,” “handling situational variability,” and “bearing emotional burdens” subthemes. The adjustment includes five subthemes: “finding resources,” “gaining experiences,” “building relationships,” “relieving stress,” and “overcoming obstacles. ” Implications for practice: Novice nurse practitioners face many challenges as they adjust to a new role during their first year on the job. New nurse practitioners develop coping strategies to help themselves adjust to their work. They also gradually gain new resources and experiences to help them stay positive in stressful situations and restore work–life balance. The challenges of transitioning from a registered nurse to a nurse practitioner cannot be overlooked. Novice nurse practitioners need appropriate support measures to adapt to advanced practice roles.