Miracle-dz/UniFAR-FTUs huggingface dataset:
CAPACIDADE COMBINATÓRIA DE HÍBRIDOS DE MILHO PARA CARACTERES AGRONÔMICOS E BROMATOLÓGICOS DA SILAGEM

Na cultura do milho, a utilizacao de delineamentos dialelicos para selecao de genotipos e muito difundida devido a facilidade de cruzamentos para obtencao dos hibridos. Foram avaliadas as capacidades geral (CGC) e especifica (CEC) de combinacao de sete hibridos comerciais de milho em dialelo completo (genitores, cruzamentos F1 e reciprocos), em dois locais do Centro-Sul paranaense (Guarapuava e Candoi), quanto as caracteristicas agronomicas e bromatologicas da silagem. Foram verificados efeitos significativos da CGC para todos os caracteres agronomicos, exceto para rendimento de graos em Candoi. Houve efeito significativo da CEC para altura de planta e rendimento de graos. Houve efeito significativo da CGC para fibra em detergente neutro (FDN) e nao houve efeito significativo da CEC para as caracteristicas bromatologicas da silagem. Os hibridos P30P34 e GNZ2004 apresentaram estimativas favoraveis da CGC para rendimento de graos e o cruzamento entre eles teve CEC tambem positiva em Guarapuava. Houve predominio dos efeitos aditivos dos genes que controlam o teor de fibra em detergente neutro (FDN) e os hibridos GNZ2004 e DKB234 se mostraram promissores para a formacao de populacoes base visando a reducao dos teores de FDN. Nao foi verificado efeito reciproco significativo nas caracteristicas avaliadas.
Mise en évidcence de la dégradation du liant ionomère dans les électrodes de pile à combustible

Ce travail de these a pour but de suivre le comportement du liant ionomere apres vieillissement en condition reelle d'utilisation de la pile. Dans un premier temps, diverses techniques de caracterisation en phase solide ont ete utilisees afin d'etudier le ionomere present dans les electrodes. La majeure partie de ces techniques se sont averees insatisfaisantes pour le suivi du vieillissement du ionomere. Seule l'analyse par diffraction rayon X (DRX) a mis en avant un changement d'organisation structurale du ionomere dans les electrodes. Par la suite, nous avons choisi de caracteriser le ionomere en solution apres extraction par l'eau. Prealablement, un protocole de quantification en 2 a 3 etapes, dans lequel intervient une quantification via le rapport signal-sur-bruit (S/N), a ete mis en place afin de quantifier le Nafion® et autres petites molecules fluores. L'extraction Soxhlet a ensuite ete realisee sur les electrodes permettant de reveler la presence d'un produit de degradation hydrosoluble apres fonctionnement en pile, a la fois en cathode et en anode. Enfin, la maceration des electrodes dans le dimethylacetamide (DMAc) a permis d'extraire le polymere Nafion® ainsi que deux acides : l'acide trifluoroacetique (TFA) et l'acide triflique (TFI). En conclusion, la correlation de l'ensemble des observations nous a permis de proposer un mecanisme de degradation du liant ionomere present dans les electrodes.
Multiple-Joint Pedestrian Tracking Using Periodic Models

Estimating accurate positions of multiple pedestrians is a critical task in robotics and autonomous cars. We propose a tracker based on typical human motion patterns to track multiple pedestrians. This paper assumes that the legs’ reflection and extension angles are approximately changing periodically during human motion. A Fourier series is fitted in order to describe the moving, such as describing the position and velocity of the hip, knee, and ankle. Our tracker receives the position of the ankle, knee, and hip as measurements. As a proof of concept, we compare our tracker with state-of-the-art methods. The proposed models have been validated by experimental data, the Human Gait Database (HuGaDB), and the Karlsruhe Institute of Technology and Toyota Technological Institute (KITTI) tracking benchmark. The results indicate that our tracker is able to estimate the reflection and extension angles with a precision of 90.97%. Moreover, the comparison shows that the tracking precision increases up to 1.3% with the proposed tracker when compared to a constant velocity based tracker.
Methylomic Signatures of High Grade Serous Ovarian Cancer

ABSTRACT High-grade serous ovarian cancer (HGSOC) harbours aberrant epigenetic features, including DNA methylation. In this study we delineate pathways and networks altered by DNA methylation and associated with HGSOC initiation and progression to a platinum-resistant state. By including tumours from patients who had been treated with the hypomethylating agent (HMA) guadecitabine, we also addressed the role of HMAs in treatment of HGSOC. Tumours from patients with primary (platinum-naïve) HGSOC (n = 20) were compared to patients with recurrent platinum-resistant HGSOC and enrolled in a recently completed clinical trial (NCT01696032). Human ovarian surface epithelial cells (HOSE; n = 5 samples) served as normal controls. Genome-wide methylation profiles were determined. DNA methyltransferase (DNMT) expression levels were examined by immunohistochemistry and correlated with clinical outcomes. Cancer-related and tumorigenesis networks were enriched among differentially methylated genes (DMGs) in primary OC vs. HOSE. When comparing platinum-resistant and primary tumours, 452 CpG island (CGI)-containing gene promoters acquired DNA methylation; of those loci, decreased (P < 0.01) methylation after HMA treatment was observed in 42% (n = 189 CGI). Stem cell pluripotency and cytokine networks were enriched in recurrent platinum-resistant OC tumours, while drug metabolism and transport-related networks were downregulated in tumours from HMA-treated patients compared to HOSE. Lower DNMT1 and 3B protein levels in pre-treatment tumours were associated with improved progression-free survival. The findings provide important insight into the DNA methylation landscape of HGSOC tumorigenesis, platinum resistance and epigenetic resensitization. Epigenetic reprogramming plays an important role in HGSOC aetiology and contributes to clinical outcomes.
Practice of COVID-19 Preventive Measures and Its Associated Factors among Students in Ghana

Abstract. Preventive measures are key to reducing COVID-19 morbidity and mortality. Our primary aim was to assess factors associated with practice of COVID-19 preventive measures among senior high school students in the Bawku Municipality, Ghana. A cross-sectional study was conducted, and data on 624 students were analyzed using multivariable logistic regression. An estimated 31.5% (95% CI: 27.8, 35.1) of the students wore a face mask often or always. Students who reported that COVID-19 can be transmitted via droplets from the nose or mouth (adjusted odds ratios [aOR]: 3.0; 95% CI: 1.1, 7.9) and students who reported that asymptomatic persons can transmit the virus (aOR: 2.0; 95% CI: 1.2, 3.6) had higher odds of wearing a face mask. However, students who reported that COVID-19 was not deadly were associated with lower odds of wearing a face mask (aOR: 0.6; 95% CI: 0.4, 1.0). Handwashing/hand sanitizing was practiced by 49.5% (95% CI: 45.6, 53.5) of students. Students in the technical program compared to the science program (aOR: 0.4; 95% CI: 0.2, 0.8) and those who reported that COVID-19 was not deadly (aOR: 0.6, 95% CI: 0.4, 1.0) had lower odds of handwashing/hand sanitizing. An estimated 46.2% (95% CI: 42.3, 50.2) of students practiced social distancing. Students who reported that COVID-19 can be transmitted via droplets from the nose or mouth were positively associated with social distancing (aOR: 2.1; 95% CI: 1.0, 4.5). There is the need to intensify education about COVID-19 in senior high schools while enforcing the practice of COVID-19 preventive measures.
Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity

One of the molecular hallmarks of amyloidoses is ordered protein aggregation involving the initial formation of soluble protein oligomers that eventually grow into insoluble fibrils. The identification and characterization of molecular species critical for amyloid fibril formation and disease development have been the focus of intense analysis in the literature. Here, using photo-induced cross-linking of unmodified proteins (PICUP), we studied the early stages of oligomerization of human transthyretin (TTR), a plasma protein involved in amyloid diseases (ATTR amyloidosis) with multiple clinical manifestations. Upon comparison, the oligomerization processes of wild-type TTR (TTRwt) and several TTR variants (TTRV30M, TTRL55P, and TTRT119M) clearly show distinct oligomerization kinetics for the amyloidogenic variants but a similar oligomerization mechanism. The oligomerization kinetics of the TTR amyloidogenic variants under analysis showed a good correlation with their amyloidogenic potential, with the most amyloidogenic variants aggregating faster (TTRL55P > TTRV30M > TTRwt). Moreover, the early stage oligomerization mechanism for these variants involves stepwise addition of monomeric units to the growing oligomer. A completely different behavior was observed for the nonamyloidogenic TTRT119M variant, which does not form oligomers in the same acidic conditions and even for longer incubation times. Thorough characterization of the initial steps of TTR oligomerization is critical for better understanding the origin of ATTR cytotoxicity and developing novel therapeutic strategies for the treatment of ATTR amyloidosis.
Capturing the Impact of Patient Portals Based on the Quadruple Aim and Benefits Evaluation Frameworks: Scoping Review

Background Despite extensive and continuing research in the area of patient portals, measuring the impact of patient portals remains a convoluted process. Objective This study aims to explore what is known about patient portal evaluations and to provide recommendations for future endeavors. The focus is on mapping the measures used to assess the impact of patient portals on the dimensions of the Quadruple Aim (QA) framework and the Canada Health Infoway’s Benefits Evaluation (BE) framework. Methods A scoping review was conducted using the methodological framework of Arksey and O’Malley. Reporting was guided by the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) extension for scoping reviews. A systematic and comprehensive search was conducted using the Ovid platform, and the following databases were searched: Ovid MEDLINE (R) ALL (including epub ahead of print, in-process, and other nonindexed citations), EMBASE, and PsycINFO. CINAHL on the EBSCO platform and Web of Science were searched for studies published between March 2015 and June 2020. A systematic gray literature search was conducted using the Google search engine. Extracted data were tabulated based on a coding template developed to categorize the literature into themes and areas of interest. Results A total of 96 studies were included for data extraction. The studies were categorized based on the QA dimensions, with strict adherence to the definitions for each dimension. From the patients’ perspective, it was determined that most evaluations focused on benefits and barriers to access, access to test results, medication adherence, condition management, medical notes, and secure messaging. From the population perspective, the evaluations focused on the increase in population outreach, decrease in disparities related to access to care services, and improvement in quality of care. From the health care workforce perspective, the evaluations focused on the impact of patients accessing medical records, impact on workflow, impact of bidirectional secure messaging, and virtual care. From the health system perspective, the evaluations focused on decreases in no-show appointments, impact on office visits and telephone calls, impact on admission and readmission rates and emergency department visits, and impact on health care use. Overall, 77 peer-reviewed studies were mapped on the expanded version of the BE framework. The mapping was performed using subdimensions to create a more precise representation of the areas that are currently explored when studying patient portals. Most of the studies evaluated more than one subdimension. Conclusions The QA and BE frameworks provide guidance in identifying gaps in the current literature by providing a way to show how an impact was assessed. This study highlights the need to appropriately plan how the impact will be assessed and how the findings will be translated into effective adaptations.
MOLECULAR INVESTIGATION OF GRAM NEGATIVE BACTERIA EXTENDED SPECTRUM -LACTAMASE IN HAEMODIALYSIS PATIENTS IN BASRAH PROVINCE, IRAQ

The right medication can decreases of fee that take a lot of money when the rapid screening techniques for detection of extended spectrum -lactamase (ESBL) producing by bacteria. In the current study, we used the genotypic methods for detection the prevalence of four genes (blaTEM, blaSHV, blaCTX-M and blaOXA) in Gram-negative bacteria in haemodialysis patients that may be causing increases spend to treat of infection by bacteria that can produce ESBLs enzymes that lead to in many cases patient dead. A total of 27 clinical isolates of Gram negative bacteria that collected from haemodialysis (blood samples, were screened for the prevalence of ESBL genes by used four specific primers to amplification blaTEM, blaSHV, blaCTX-M and blaOXA genes. Results showed that 24 (88.9%) out of 27 Gram negative bacteria were ESBL positive. The highest rate of blaOXA gene was 17 (70.8%) while blaTEM, blaSHV were 13 (54.2%) and blaCTX-M was the lowest (8.3%) out of 24 ESBL positive isolates.
Correlating STED and synchrotron XRF nano-imaging unveils cosegregation of metals and cytoskeleton proteins in dendrites

Zinc and copper are involved in neuronal differentiation and synaptic plasticity but the molecular mechanisms behind these processes are still elusive due in part to the difficulty of imaging trace metals together with proteins at the synaptic level. We correlate stimulated emission depletion (STED) microscopy of proteins and synchrotron X-ray fluorescence (SXRF) imaging of trace metals, both performed with 40 nm spatial resolution, on primary rat hippocampal neurons. We achieve a detection limit for zinc of 14 zeptogram (10-21 g) per pixel. We reveal the co-localization at the nanoscale of zinc and tubulin in dendrites with a molecular ratio of about one zinc atom per tubulin-αβ dimer. We observe the co-segregation of copper and F-actin within the nano-architecture of dendritic protrusions. In addition, zinc chelation causes a decrease in the expression of cytoskeleton proteins in dendrites and spines. Overall, these results indicate new functions for zinc and copper in the modulation of the cytoskeleton morphology in dendrites, a mechanism associated to neuronal plasticity and memory formation.
Wellbeing in relation to adjustment and emotional maturity among adults

Wellbeing is related to our sense of autonomy, capability and relatedness, as well as to our physical health and inner resources. Adult is a crucial period for establishing positive health and social behaviors. It is a time when young people are undergoing rapid emotional, physical and intellectual changes, and when they begin the transition from childhood to adolescence to independent adulthood. The present study on well being considered the significance of emotional maturity and adjustment. The study shows a significant positive inter correlations among well-being, emotional maturity and the level of adjustment in adults, which indicates that higher the emotional maturity scores and better the level of adjustment and higher will be the wellbeing in adults.
Feeling Gratitude is Associated with Better Well-being across the Life Span: A Daily Diary Study during the COVID-19 Outbreak

Abstract Objectives Numerous studies have shown that gratitude can improve mental health of people facing stressful events. However, most studies in this area have been based on laboratory experiments and retrospective surveys, rather than actual situations in which people are experiencing stress. Moreover, few studies have examined whether age moderates the benefits of gratitude. Coronavirus disease 2019 (COVID-19) has caused enormous psychological distress worldwide. Evidence-based strategies are needed to enhance well-being during this stressful time. This study attempted to fill these gaps by examining the benefits of feeling gratitude every day during the COVID-19 outbreak. Method A sample of 231 participants from mainland China aged 18 to 85 years participated in a 14-day daily diary study. After a pretest to collect demographic data, information on gratitude, daily positive and negative affect, perceived stress related to COVID-19, and subjective health were measured using daily questionnaires on 14 consecutive days. One month after the daily diary period, information on affective experiences, life satisfaction, and subjective health was collected as a follow-up survey. Results On days when individuals feel more gratitude than usual, they report more positive affect, a lower level of perceived stress related to COVID-19, and better subjective health on the concurrent day (Day N). Individuals also report a lower level of stress related to COVID-19 on the following day (Day N+1), when they feel more gratitude than usual on Day N. Higher levels of gratitude across the 14-day study period was associated with a higher level of positive affect and a lower level of negative affect, but was not associated with life satisfaction or subjective health at the one-month follow-up assessment. Discussion These findings demonstrate the benefits of gratitude in a naturalistic situation that induced stress and anxiety.
Short-term and long-term effects of rapid maxillary expansion on the nasal soft and hard tissue.

OBJECTIVES To evaluate nasal soft and hard tissue changes immediately post-rapid maxillary expansion (RME) and to assess the stability of these changes using cone beam computed tomography (CBCT). MATERIALS AND METHODS A total of 35 treatment group (TG) patients (18 girls, 17 boys; 9.39 ± 1.4) had a pre-RME CBCT and a post-RME CBCT approximately 66 days after expansion, and 25 patients had a follow-up CBCT 2.84 years later. A total of 28 control group (CG; no RME) patients (16 girls, 12 boys; 8.81 ± 1.6) had an initial CBCT and a CBCT an average of 2.25 years later. Soft and hard tissue nasal landmarks were measured in transverse, sagittal, and coronal planes of space on CBCT scans. Differences within the same group were evaluated by paired t-tests or Wilcoxon signed-rank tests. Long-term comparisons between TG and CG were evaluated by independent-sample t-tests or Wilcoxon rank-sum tests. RESULTS Immediately post-RME, there were statistically significant mean increases of 1.6 mm of alar base width, 1.77 mm of pyriform height, and 3.57 mm of pyriform width (P < .05). CG showed the significant increases over 2.25 years (P < .001). Compared with CG, the long-term evaluation of TG demonstrated only pyriform height and pyriform width showed a statistically significant difference (P < .01). CONCLUSIONS Although RME produced some significant increase on the nasal soft tissue immediately after expansion, it regressed to the mean of normal growth and development over time. However, long-term evaluation of TG compared with CG showed only pyriform height and pyriform width to be affected by RME.
Sociodemographic and clinical characteristics of patients with recurrent psychiatric readmissions in Qatar

Objective To examine the sociodemographic and clinical characteristics of psychiatric patients with recurrent psychiatric readmissions (RPR). Methods A retrospective study was conducted at Hamad General Hospital in Qatar on psychiatric patients with recurrent readmissions from August 2018 to January 2019. Results Of 380 psychiatric patients admitted during the study period, 40 (10.5%) were readmitted within 30 days of discharge. Most of the patients who were readmitted were single, male and unemployed. Psychotic spectrum disorder was the most frequent psychiatric condition and was diagnosed in 18 (45%) patients. A total of 30% of the patients were receiving treatment with anti-psychotics, and a similar number received more than one medication. Most patients showed poor or no compliance. Only 12.5% of patients stayed in the hospital for more than 5 weeks in their last admission during the study period. Conclusions Poor compliance, male sex and single status were the most common demographic and clinical features of patients with RPR. Post-discharge psychiatric care should be tailored to meet the requirements of patients prone to RPR.
Anisotropic Nucleation, Growth and Ripening under Stirring—A Phenomenological Model

The anisotropic formation of elongated metal-oxide aggregates in water under intensive stirring is analyzed. It is treated in terms of anisotropic ballistically mediated aggregation kinetics in open systems. The basic kinetic equations describing the stages of homogeneous nucleation, independent growth, and ripening of the aggregates are formulated for the open system under the external influence with the stirring intensity as the main parameter governing the process. The most significant elongation of the aggregates is shown to evolve at the ripening stage.
Rosmarinic Acid–Human Pharmacokinetics and Health Benefits

Abstract Rosmarinic acid is a phenolic compound commonly found in the Lamiaceae (Labiateae) plant species. It is considered responsible for a wide spectrum of biological and pharmacological activities of plants containing this compound. The aim of the current review is to present the fate of rosmarinic acid inside the human body, explained through pharmacokinetic steps and to briefly present the health benefits of RA. Pharmacokinetics was at first studied in animal models, but several studies were conducted in humans as well. This compound can be applied topically, pulmonary, intranasally, and via intravenous infusion. However, peroral application is the main route of entry into the human body. Presumably, it is mainly metabolized by the gut microflora, providing simple, more easily absorbed phenolic units. Inside the body, the rosmarinic acid molecule undergoes structural changes, as well as conjugation reactions. Renal excretion represents the main path of elimination. Previously conducted studies reported no serious adverse effects of herbal remedies containing RA, as well as their positive effects on human health. In addition to in vitro studies, clinical investigations suggested its benefits in dermatological, allergic, and osteoarthritic disorders, as well as for improving cognitive performance and in metabolic syndrome treatment. Future studies should investigate the kinetics during long-term application in patients who would have potential benefits from RA usage. Pharmaceutical formulations designed to prevent the fast metabolism of RA and allow its penetration into other compartments of the human body are also interesting topics for future research.