Miracle-dz/UniFAR-FTUs huggingface dataset:
Convection in a rapidly rotating spherical shell with an imposed laterally varying thermal boundary condition

We investigate thermally driven convection in a rotating spherical shell subject to inhomogeneous heating on the outer boundary, extending previous results to more rapid rotation rates and larger amplitudes of the boundary heating. The analysis explores the conditions under which steady flows can be obtained, and the stability of these solutions, for two boundary heating modes: first, when the scale of the boundary heating corresponds to the most unstable mode of the homogeneous problem; second, when the scale is larger. In the former case stable steady solutions exhibit a two-layer flow pattern at moderate rotation rates, but at very rapid rotation rates no steady solutions exist. In the latter case, stable steady solutions are always possible, and unstable solutions show convection rolls that cluster into nests that are out of phase with the boundary anomalies and remain trapped for many thermal diffusion times.
First Aid Management and Myths of Epistaxis among General Adult Saudi population of Al Majmaah, Saudi Arabia

To evaluate the knowledge, awareness, and attitude (myths) of the general population about the first aid management of epistaxis. This cross-sectional study was conducted via an online questionnaire from March to August 2022. We generated google forms for data collection. The link to this google form was randomly shared on WhatsApp and Facebook platforms. A previously used questionnaire was used and tested in the pilot study over a sample of 20 participants. The questionnaire contained socio-demographic information including sex, age, occupation, and residence. Furthermore, the level of awareness was measured on behalf of epistaxis causes and actions which were further subdivided into many categories. Myths were also observed through a questionnaire For this cross-sectional study 407 participants aged 15 to 55 years were recruited. A total of 325 participants encountered epistaxis once in their lifetime. The 30% participants of in our study reported spontaneous epistaxis while 4.4% and 4.9% encountered it due to nasal trauma and fingernail trauma. In 7.6% of participants, epistaxis occurred due to bleeding disorders while 23% reported hypertension as the major reason. We observed that 94% population was familiar with the proper position that epistaxis patients required to control bleeding. Sitting with the head tilted forward as a coping mechanism was used in 48.9% of participants with 199 individuals practicing this while sitting with the head tilted backward was practiced by 117 (28.7%) participants. The general population had enough knowledge to manage epistaxis. The awareness levels of the population show a positive reflection of the healthcare system. However, we recommend that further studies should be conducted with a large sample size to evaluate the validity of our research.
Community Assessment for a Low-Carbohydrate Nutrition Education Program in South Africa

Eat Better South Africa (EBSA) is an organization that provides low-carbohydrate, high-fat (LCHF) nutrition and health education programs for women from under-resourced South African communities. Community assessments are essential to explore participants’ potential facilitators and challenges of adhering to new dietary behaviours and should be implemented before any dietary interventions. This study is a qualitative community assessment to enable the EBSA program to better meet potential participants’ needs and explore their willingness to enrol in the EBSA program. Sixty women from two communities in the Western Cape were interviewed through six focus group discussions. A thematic analysis was conducted using NVivo 12 software, and four themes were developed around the women’s (1) role within the households; (2) dietary behaviour; (3) health perceptions; and (4) willingness to participate in an LCHF program. Women mentioned that they were responsible for cooking and shopping for their households. They expressed their understanding of healthy and unhealthy behaviours and their dietary patterns. Some women showed concerns about LCHF diets, but others wanted to learn more due to their knowledge of other people’s positive experiences with the diet. There was a general desire to become healthy. However, the women anticipated dietary behaviour change to be challenging. Those challenges mostly revolved around their socioeconomic environments. The findings are intended to inform EBSA (or other nutrition interventions) on what to consider when implementing their interventions in these communities.
Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Glp-1 Receptor Agonists: A Multidisciplinary Expert Consensus

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are indicated in type 2 diabetes and obesity for their high efficacy in controlling glycaemia and inducing body weight loss, respectively. Patients may develop gastrointestinal adverse events (GI AEs), namely nausea, vomiting, diarrhoea and/or constipation. To minimize their severity and duration, healthcare providers (HCPs) and patients must be aware of appropriate measures to follow while undergoing treatment. An expert panel comprising endocrinologists, nephrologists, primary care physicians, cardiologists, internists and diabetes nurse educators convened across virtual meetings to reach a consensus regarding these compelling recommendations. Firstly, specific guidelines are provided about how to reach the maintenance dose and how to proceed if GI AEs develop during dose-escalation. Secondly, specific directions are set about how to avoid/minimize nausea, vomiting, diarrhoea and constipation symptoms. Clinical scenarios representing common situations in daily practice, and infographics useful to guide both HCPs and patients, are included. These recommendations may prevent people with T2D and/or obesity from withdrawing from GLP-1 RAs treatment, thus benefitting from their superior effect on glycaemic control and weight loss.
A Prospective Population-Based Study of Cardiovascular Disease Mortality following Treatment for Breast Cancer among Men in the United States, 2000–2019

Male breast cancer is rare but its incidence and mortality are increasing in the United States, with racial/ethnic disparities in survival reported. There is limited evidence for cardiotoxicity of cancer treatment among men with breast cancer. We evaluated the relation between breast cancer treatment and cardiovascular disease (CVD) mortality among men and investigated the salient roles that race/ethnicity play on this relation. Data were from 5216 men with breast cancer aged ≥ 40 years from the Surveillance, Epidemiology, and End Results program who were diagnosed from 2000 to 2019 and underwent surgery. Competing risk models were used to estimate hazards ratios (HR) and 95% confidence intervals (CI). During a median follow-up of 5.6 years, 1914 deaths occurred with 25% attributable to CVD. In multivariable-adjusted models, men who received chemotherapy had elevated risk for CVD (HR: 1.55, 95%CI: 1.18–2.04). This risk was higher among Hispanic men (HR: 3.96, 95%CI: 1.31–12.02) than non-Hispanic Black and non-Hispanic White men. There was no significant association between radiotherapy and CVD deaths. In this population-based study, treatment with chemotherapy was associated with elevated risk of CVD mortality in men with breast cancer. Racial/ethnic disparities in the association of chemotherapy and CVD mortality were observed.
Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours

DNA polymerase theta (Polθ)-mediated end joining (TMEJ) is, along with homologous recombination (HR) and non-homologous end-joining (NHEJ), one of the most important mechanisms repairing potentially lethal DNA double-strand breaks (DSBs). Polθ is becoming a new target in cancer research because it demonstrates numerous synthetically lethal interactions with other DNA repair mechanisms, e.g., those involving PARP1, BRCA1/2, DNA-PK, ATR. Inhibition of Polθ could be achieved with different methods, such as RNA interference (RNAi), CRISPR/Cas9 technology, or using small molecule inhibitors. In the context of this topic, RNAi and CRISPR/Cas9 are still more often applied in the research itself rather than clinical usage, different than small molecule inhibitors. Several Polθ inhibitors have been already generated, and two of them, novobiocin (NVB) and ART812 derivative, are being tested in clinical trials against HR-deficient tumors. In this review, we describe the significance of Polθ and the Polθ-mediated TMEJ pathway. In addition, we summarize the current state of knowledge about Polθ inhibitors and emphasize the promising role of Polθ as a therapeutic target.
Synthesis, Thermal Behavior, and Mechanical Properties of Fully Biobased Poly(Hexamethylene 2,5-Furandicarboxylate-Co-Sebacate) Copolyesters

In this research, three fully biobased poly(hexamethylene 2,5-furandicarboxylate-co-sebacate) (PHFSe) copolyesters with low contents of hexamethylene sebacate (HSe) unit (10 mol%, 20 mol%, and 30 mol%) were successfully synthesized through a two-step transesterification/esterification and polycondensation method. The chemical structure and actual composition of PHFSe copolyesters were confirmed by hydrogen nuclear magnetic resonance. The thermal behavior and mechanical property of PHFSe copolyesters were investigated and compared with those of the poly(hexamethylene 2,5-furandicarboxylate) (PHF) homopolymer. Both PHFSe copolyesters and PHF showed the high thermal stability. The basic thermal parameters, including glass transition temperature, melting temperature, and equilibrium melting temperature, gradually decreased with increasing the HSe unit content. PHFSe copolyesters crystallized more slowly than PHF under both the nonisothermal and isothermal melt crystallization conditions; however, they crystallized through the same crystallization mechanism and crystal structure. In addition, the mechanical property, especially the elongation at break of PHFSe copolyesters, was obviously improved when the HSe unit content was greater than 10 mol%. In brief, the thermal and mechanical properties of PHF may be easily tuned by changing the HSe unit content to meet various practical end-use requirements.
THE IMPACT OF TRANSACTION COSTS ON MANAGEMENT DECISIONS (ON THE EXAMPLE OF UKRAINIAN COMPANIES)

The purpose of the article is to study the impact of transaction costs on managerial decision-making on the example of Ukrainian enterprises. The article notes that, despite the significant achievements of the institutional theory, there are still questions about the clarity of understanding of its key concepts and definitions, the content of transaction costs and the concept of their minimization, the expediency and efficiency of the existence of certain types of transaction costs. The subject of the study is the essence of transaction costs of the enterprise and their modern classification. The methodological basis of the study was an integrated approach to the essence and classification of transaction costs, as well as general scientific and special research methods: retrospective and systematic analysis, comparison and generalization, grouping and sampling, methods of building linear and nonlinear economic and statistical models with constraints. As noted above, the main issue of the study was the classification of transaction costs. The economic situation in Ukraine was assessed, which allowed to determine that transaction costs are quite high for enterprises due to: insufficient development of markets, unformed structure of institutions, complex and ambiguous legislation, significant tax pressure and existing facts of corruption. The authors noted that the list of components of transaction costs is constantly updated due to the complication of the socio-economic conditions for doing business associated with crisis-forming force majeure factors (in particular, the COVID-19 pandemic), which have become very significant for the world economy and have significantly changed approaches to the allocation of investment resources. As a result of the study, it is proposed to supplement the existing classification of transaction costs with costs associated with adapting to new business conditions ("adaptation cost"), which together characterize the ability of an enterprise to adapt to new conditions of functioning and development. The main conclusions of the study include the fact that, given current trends, reducing transaction costs is becoming a priority issue. At the same time, in the context of the proposed classification, a model for minimizing transaction costs was developed for the first time, which includes a modern classification of transaction costs and provides the possibility of their modeling for a more complete and logical calculation. According to the authors, the presented model will provide an opportunity to more correctly determine the effectiveness of management decisions related to investments in the core business of the enterprise. It is important to note that, given the basic provisions of institutional theory, a significant amount of transaction costs, in principle, can neutralize the investment process. Thus, the study is of both theoretical and practical importance and gives an idea of solving a number of both industrial and social problems and can become the basis for further research.
Diet and the gut-lung axis in cystic fibrosis – direct & indirect links

ABSTRACT Cystic fibrosis (CF) is a multisystem, autosomal, recessive disease primarily affecting the lungs, pancreas, gastrointestinal tract, and liver. Whilst there is increasing evidence of a microbial ‘gut-lung axis’ in chronic respiratory conditions, there has been limited analysis of such a concept in CF. We performed a comprehensive dietary and microbiota analysis to explore the interactions between diet, gastrointestinal microbiota, respiratory microbiota, and clinical outcomes in children with CF. Our results demonstrate significant alterations in intestinal inflammation and respiratory and gastrointestinal microbiota when compared to age and gender matched children without CF. We identified correlations between the gastrointestinal and respiratory microbiota, lung function, CF pulmonary exacerbations and anthropometrics, supporting the concept of an altered gut-lung axis in children with CF. We also identified significant differences in dietary quality with CF children consuming greater relative proportions of total, saturated and trans fats, and less relative proportions of carbohydrates, wholegrains, fiber, insoluble fiber, starch, and resistant starch. Our findings position the CF diet as a potential modulator in gastrointestinal inflammation and the proposed gut-lung axial relationship in CF. The dietary intake of wholegrains, fiber and resistant starch may be protective against intestinal inflammation and should be explored as potential therapeutic adjuvants for children with CF.
Maternal Metabolites Indicative of Mental Health Status during Pregnancy

Approximately 25% of individuals report poor mental health during their pregnancy or postpartum period, which may impact fetal neurodevelopment, birth outcomes, and maternal behaviors. In the present study, maternal serum samples were collected from pregnancies at 28–32 weeks gestation from the All Our Families (Alberta, Canada) cohort and assessed using nuclear magnetic resonance spectroscopy (1H-NMR) and inductively coupled plasma-mass spectrometry (ICP-MS). Individuals with poor mental health at 34–36 weeks gestation were age-matched with mentally healthy pregnant controls. Metabolites were examined against validated self-reported mental health questionnaires for associations with depressive symptoms (Edinburgh Perinatal Depression Scale) and anxiety symptoms (Spielberger State-Trait Anxiety Inventory). 1H-NMR metabolites were identified for depression (alanine, leucine, valine, methionine, phenylalanine, glucose, lactate, 3-hydroxybutyrate, and pyruvate) and anxiety (3-hydroxybutyrate). For ICP-MS, antimony and zinc were significant for depression and anxiety, respectively. Upon false discovery rate (FDR) correction at 10%, five 1H-NMR metabolites (alanine, leucine, lactate, glucose, and phenylalanine) for depression remained significantly increased. Although results warrant further validation, the identified metabolites may serve as a predictive tool for assessing mental health during pregnancy as earlier identification has the potential to aid intervention and management of poor mental health symptomology, thus avoiding harmful consequences to both mother and offspring.
How Do Tourists Use Metaheuristics for Decision-Making Mediated by Smartphones in a Destination?

The use of smartphones has empowered tourists to make travel decisions while at a destination. The purpose of this paper is to explore how tourists use metaheuristics to achieve a near-optimal solution for onsite decisions mediated by smartphones. An event-based narrative inquiry technique with semi-structured interviews was used to collect the data. The findings identify two types of decision contexts based on temporal and geographic distance to direct experience/consumption. The findings also reveal that tourists use serial heuristics for a near-optimal solution under different decision contexts, and this solution is achieved through three steps of a tourist decision journey including the initialization solution, acceptance and selection, and final decision. These heuristics can be consciously deployed or unconsciously triggered. The findings offer marketing managers direction regarding what to emphasize when delivering marketing stimuli in onsite destination decision-making contexts.
A constrained optimization algorithm based on the simplex search method

In this article, a robust method is presented for handling constraints with the Nelder and Mead simplex search method, which is a direct search algorithm for multidimensional unconstrained optimization. The proposed method is free from the limitations of previous attempts that demand the initial simplex to be feasible or a projection of infeasible points to the nonlinear constraint boundaries. The method is tested on several benchmark problems and the results are compared with various evolutionary algorithms available in the literature. The proposed method is found to be competitive with respect to the existing algorithms in terms of effectiveness and efficiency.
Photosynthetic Plasticity and Stomata Adjustment in Chromosome Segment Substitution Lines of Rice Cultivar KDML105 under Drought Stress

The impact of increasing drought periods on crop yields as a result of global climate change is a major concern in modern agriculture. Thus, a greater understanding of crop physiological responses under drought stress can guide breeders to develop new cultivars with enhanced drought tolerance. In this study, selected chromosome segment substitution lines of KDML105 (KDML105-CSSL) were grown in the Plant Phenomics Center of Kasetsart University in Thailand under well-watered and drought-stressed conditions. Physiological traits were measured by observing gas exchange dynamics and using a high-throughput phenotyping platform. Furthermore, because of its impact on plant internal gas and water regulation, stomatal morphological trait variation was recorded. The results show that KDML105-CSS lines exhibited plasticity responses to enhance water-use efficiency which increased by 3.62%. Moreover, photosynthesis, stomatal conductance and transpiration decreased by approximately 40% and plant height was reduced by 17.69%. Stomatal density tended to decrease and was negatively correlated with stomatal size, and stomata on different sides of the leaves responded differently under drought stress. Under drought stress, top-performing KDML105-CSS lines with high net photosynthesis had shorter plant height and improved IWUE, as influenced by an increase in stomatal density on the upper leaf side and a decrease on the lower leaf side.
Recent advances in genetically modified large-animal models of human diseases

Large-animal models show greater advantages than rodents in recapitulating human genetic diseases, primarily because of their higher similarity to humans in terms of anatomy, physiology and genetics. Notably, as genome-editing technologies have rapidly improved, particularly transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 (CRISPR-associated protein 9) systems, their application in biomedical research has accelerated. A variety of genetically modified large-animal models, including non-human primates, pigs, dogs, bovines and sheep, have been produced to recapitulate human inherited disorders, thus providing novel biological and translational insights. Here, we review recent progress in the generation of large-animal models over the past 5 years and summarize their use in studying human genetic diseases, focusing on the nervous system, cardiovascular and metabolic systems, the immune system, xenotransplantation, the reproductive system and embryonic development.
ON A CONJECTURE OF TREVES : ANALYTIC HYPOELLIPTICITY AND POISSON STRATA

We prove analytic hypoellipticity for a class of sums of squares of vector fields including a model operator proposed by F. Treves [30] in conjunction with ideals of analytic functions whose Poisson stratification were conjectured to be related with analytic hypoellipticity. We also state and discuss a condition suggested by Treves’ conjecture which may have implications for Gevrey hypoellipticity and, using only subellipticity, prove some sharp Gevrey results stated by Christ [7], [6].
Category of Negation Paradigm in Diachrony

--- The negation in logic and linguistics, negation as a grammatical category on the morphological and syntactic levels are substantiated in the article. It is concluded that in broad semantic terms negation can be expressed in morphologic and syntactic ways in natural language. On the morphological level, negative affixes paradigm and separate parts of speech are taken into consideration, while on the syntactic level the whole negative sentence that includes one or more than one negator is observed. Negation is expressed using affixes that have explicative and implicative components in their meaning. Authentic affixes preserve the semantic meaning of the words they etymologically derive from, giving the word they join to, a special shade of negation. The main source of enrichment of the negative affixes paradigm and their new meaning are affixes borrowed from other languages. The study of the category of negation on different levels in diachronic aspects can help to observe the development of particular parts of speech, which can express negation, and serve as a base for further studies of negation in the different discourses and communicative situations.