Miracle-dz/UniFAR-FTUs huggingface dataset:
CORONARY ARTERY DISEASE Original Studies Quality of Life Benefits of Percutaneous Coronary Intervention for Chronic Occlusions

Objectives: We aimed to compare quality of life benefits of percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) with non-CTO PCI. Background: Data quantifying the benefits of PCI of CTO are inconsistent. Methods: We leveraged a 10center prospective PCI registry including Seattle Angina Questionnaire (SAQ) assessment at the time of PCI and in follow-up. We propensity matched attempted CTO PCIs with up to 10 non-CTO PCIs. The primary analysis compared changes between baseline and 6 months in SAQ Physical Limitation (PL), Quality of Life (QoL); Angina Frequency (AF) scores as well as the Rose Dyspnea scores (RDS) and the EQ5D Visual Analogue Scale (VAS). Noninferiority was assessed for quality of life changes between CTO and non-CTO PCI. Results: In 3,303 patients enrolled, 167 single-vessel CTOs were attempted; 147 (88%) were matched with 1,616 non-CTO PCI. Baseline PL (73.0 vs. 77.4, P 5 0.039) and VAS (66.4 vs. 70.8, P 5 0.005) scores were lower for CTO. There was no difference in AF, QoL, or RDS scores. At 6-month follow-up, all SAQ scores improved (P < 0.05 vs. baseline for all) and were equivalent for CTO and Non-CTO (P 5 NS for all). VAS scores remained lower for CTO, but improved in both groups (P < 0.05 vs. baseline for both). Formal noninferiority testing demonstrated that CTO PCI was not inferior to non-CTO PCI (P 0.02 for all). Conclusions: Symptoms, function, QoL, and dyspnea improve to the same degree following CTO PCI as compared with non-CTO PCI. Symptom relief supports CTO PCI to improve patients’ quality of life. VC 2013 Wiley Periodicals, Inc.
A Simple and Valid Method to Calculate Wheelchair Frame Rotation Using One Wheel-Mounted IMU

Wheelchair sports have been using Inertial Measurement Units (IMU) to measure mobility metrics during training, testing and competition. Presently, the most suitable solution to calculate wheelchair speed and frame rotation is the 3IMU method as there is uncertainty about the ability of a one wheel-mounted IMU (1IMU) approach to calculate wheelchair frame rotational kinematics. A new method for calculating wheelchair frame rotational kinematics using a single wheel-mounted IMU is presented and compared to a criterion measurement using a wheelchair-frame-mounted IMU. Goodness-of-fit statistics demonstrate very strong linear relationships between wheelchair frame angular velocity calculated from the wheel-mounted IMUs and a wheelchair-frame-mounted IMU. Root mean square error (RMSE), mean absolute error (MAE) and Bland–Altman analysis show very small differences between the wheelchair frame angular velocity calculated from the wheel-mounted IMUs and the wheelchair-frame-mounted IMU. This study has demonstrated a simple and accurate approach to estimating wheelchair frame rotation using one wheel-mounted IMU during an elite wheelchair athlete agility task. Future research is needed to reexamine and compare wheelchair mobility metrics determined using the 3IMU and 1IMU solutions using this new approach.
Groundwater Flow Through a Constructed Treatment Wetland

Abstract : This study examines the flow of groundwater through one of the treatment cells. A major goal of the study is to determine whether the system design facilitates uniform vertical flows through the subsurface soil sediments or if preferential flows occur. Conceptually, uniform flows will achieve the most efficient degree of contaminant removal possible by evenly dispersing the groundwater contaminants throughout the full volume of the subsurface media. A three-dimensional grid of piezometers is used to generate potentiometric contour maps, and in-situ tests of hydraulic conductivity facilitate construction of a numerical computer model. The contours of hydraulic head, measured conductivities, and numerical model simulations imply preferential flows and a wetland operating at less than an optimal level of efficiency. Hydraulic residence times for representative water particles released in the model range from 16.5 hours to 15 days with a mean residence time of three days. The divergence from the uniform flow ideal suggests an alternative construction approach may be appropriate.
PLEKHA4 is Associated with Tumour Microenvironment, Stemness, Proliferation and Poor Prognosis of Gliomas.

BACKGROUND Glioma is the most common intracranial malignancy. Immune-infiltration and tumour stemness are associated with the prognosis of glioma. Although pleckstrin homology containing family A, number 4 (PLEKHA4) is widely expressed in various human cancers, its role in glioma remains unclear. METHODS We examined the features and clinical significance of PLEKHA4 in gliomas by analysing relevant data from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases. Gene set enrichment analysis (GSEA) was performed to determine the possible functions and pathways involving PLEKHA4 in glioma. The relationship between PLEKHA4 expression and the degree of oncogenic dedifferentiation was analysed using stemness scores (ss) calculated from epigenetic and transcriptomic features. We also explored the relationship between PLEKHA4 expression and immune cell infiltration in gliomas using the CIBERSORT databases. Furthermore, drug sensitivity analysis was performed using datasets from the GDSC and GTRP databases. In addition, we performed relevant in vitro experimental studies. RESULTS PLEKHA4 DNA hypomethylation status was associated with its high expression in glioma tissues as well as poor prognoses. Univariate and multivariate Cox analyses indicated that PLEKHA4 expression may be considered as an independent prognostic factor in patients with glioma. GSEA indicated that high PLEKHA4 expression was associated with Janus kinase (JAK)/signal transducer and activator of transcription (STAT), Wingless-Type MMTV Integration Site Family (Wnt), JUN N-terminal kinase (JNK) signalling pathways and involved in apoptotic, cytoskeletal, and cell adhesion biological processes (BPs). In addition, increased PLEKHA4 expression was associated with higher glioma stemness scores than lower PLEKHA4 expression levels. Furthermore, the expression of PLEKHA4 was shown to be associated with glioma infiltration by CD4+ T cells, B cells, neutrophils, macrophages, and dendritic cells. Drug sensitivity analysis also showed that PLEKHA4 expression was negatively correlated with the sensitivity of several small molecule kinase inhibitors. Furthermore, in vitro experiments confirmed that PLEKHA4 knockdown inhibited the proliferation of glioma cells. CONCLUSIONS PLEKHA4 is highly expressed in glioma tissues and correlated with tumour stemness, immune cell infiltration and proliferation, suggesting its potential as a novel prognostic biomarker and therapeutic target in glioma.
A novel approach to attention mechanism using kernel functions: Kerformer

Artificial Intelligence (AI) is driving advancements across various fields by simulating and enhancing human intelligence. In Natural Language Processing (NLP), transformer models like the Kerformer, a linear transformer based on a kernel approach, have garnered success. However, traditional attention mechanisms in these models have quadratic calculation costs linked to input sequence lengths, hampering efficiency in tasks with extended orders. To tackle this, Kerformer introduces a nonlinear reweighting mechanism, transforming maximum attention into feature-based dot product attention. By exploiting the non-negativity and non-linear weighting traits of softmax computation, separate non-negativity operations for Query(Q) and Key(K) computations are performed. The inclusion of the SE Block further enhances model performance. Kerformer significantly reduces attention matrix time complexity from O(N2) to O(N), with N representing sequence length. This transformation results in remarkable efficiency and scalability gains, especially for prolonged tasks. Experimental results demonstrate Kerformer's superiority in terms of time and memory consumption, yielding higher average accuracy (83.39%) in NLP and vision tasks. In tasks with long sequences, Kerformer achieves an average accuracy of 58.94% and exhibits superior efficiency and convergence speed in visual tasks. This model thus offers a promising solution to the limitations posed by conventional attention mechanisms in handling lengthy tasks.
Effect of Envy on Intention to Cyberbully in Social Network Sites: Examining Two Competing Views

Research analyzing the growing, worrisome phenomenon of cyberbullying in social network sites (SNSs) tends to adopt a cognitive perspective. This study instead investigates SNS envy, an essential emotion often experienced by users, and its relationship with cyberbullying intentions. The authors apply appraisal theory of emotion as a framework to conceptualize the effects of SNS envy, then propose two competing views: a direct effect premised in general strain theory and an indirect effect rooted in moral disengagement theory. The examinations of these competing views use survey data gathered from Facebook. The results support the indirect but not the direct effect, suggesting that envy influences cyberbullying intentions through moral disengagement. This study explicates how envious users rationalize their cyberbullying behaviors by cognitively reinterpreting existing perceptions of the advantages exhibited by envied others in a SNS, which reveals the importance of considering negative emotions to explain the unsettling cyberbullying phenomenon more fully.
The solvents influence in the continuous extraction to antioxidant and αglucosidase inhibition of Cinnamomum burmannii bark

The proanthocyanidins, the polyphenolic compounds from Cinnamomum burmannii (Lauraceae), have been known for their insulin-like effects. The different use of solvents and extraction methods would influence the bioactive phytochemicals. This research examined the solvents used in the continuous extraction method to provide a higher yield of bioactive extracts. The use of ethanol only compared to the gradual polarity of nhexane, ethyl acetate, and ethanol in the soxhletation to the standardized dried cinnamon bark. The extracts were then analyzed for their total phenolic content, antioxidant, and αglucosidase inhibition. The extracts contained essential oils, tannins and flavonoids, triterpenoids, coumarins, and glycosides. The ethanolic solvent provides a higher yield and total phenolic content compared to other extracts. The ethanolic extracts phenolic content was highest, and its IC50 DPPH antioxidant activity was no significant difference from rutin. The IC50 α-glucosidase inhibition of most extracts was lower than acarbose, thus classified as vital to moderate activity. The correlation analysis preceded a negative result of total phenolic content to α-glucosidase inhibition activities. These results supported the beneficial use of C. burmannii bark ethanol extract as α-glucosidase inhibitor and oxidative stress relieving in diabetes dietary supplements.
A finite volume–alternating direction implicit method for the valuation of American options under the Heston model

ABSTRACT A finite volume–alternating direction implicit method is proposed for numerical valuation of the American options under the Heston model. It is based on decoupling correlated stock price process and volatility process so that corresponding partial differential operator does not contain the mixed partial derivative term. Hence, the proposed method is numerically simple and fast. Numerical results are presented to examine the accuracy of the proposed method and to compare it with the others.
A Novel Fluorescence Probe Based on Azamonardine for Detecting and Imaging Cysteine in Cells and Zebrafish with High Selectivity and Sensitivity

A novel fluorescent probe based on azamonardine (Aza) fluorophore was designed and synthesized for the highly selective detection of cysteine (Cys) in vivo and in vitro. After reacting with acryloyl chloride, the fluorescence of Aza is effectively quenched, resulting in the formation of the Aza-acryl probe. Upon the addition of Cys, the ester bond of Aza-acryl is cleaved, releasing a new compound (Compound 1) with strong fluorescence, thereby achieving fluorescence turn-on detection of Cys. The structure of Aza-acryl was characterized using X-ray crystallography and NMR spectroscopy. Additionally, density functional theory was employed to elucidate the quenching mechanism of the acyl group on the Aza. Aza-acryl exhibits high selectivity towards Cys and distinguishes it from other biothiols such as homocysteine (Hcy) and glutathione (GSH). The mechanism of Aza-acryl for detecting Cys was investigated through HPLC, NMR spectroscopy, high-resolution mass spectrometry, and reaction kinetics experiments. Aza-acryl demonstrates excellent imaging capabilities for Cys in cells and zebrafish, providing a reliable and selectable tool for the detection and imaging of Cys in biological systems.
A phenomenological study: Exploring the needs, wants, and desires from the voices of African-American males desiring to graduate from community college

The purpose of this qualitative phenomenological study was to explore factors that could lead to academic success for African-American males enrolled in community college. By conducting a phenomenological study, those factors leading to graduation will be derived from the particular lens of perception of the participants’ lived experiences. The guiding theories are those of Derrick Bell’s Critical Race Theory (CRT, 1977), Vincent Tinto’s (1975) Theory of Departure, and John Bean’s (1979) Theory of Student Attrition. A convenience participant sample totaling 10 African-American males was comprised of students who were currently enrolled in a community college. The data collected for this study was garnered from a questionnaire, interviews, and surveys. Said data was analyzed using Moustakas’ (1994) phenomenological seven-step approach. The data from the study resulted in three themes emerging from the data. The themes included trauma, anger, and systems of support. The final chapter is composed of recommendations based on data results and indicated unresolved research privations.
Current Opinions on the Relationship Between CMTM Family and Hepatocellular Carcinoma

Abstract Hepatocellular carcinoma (HCC) is a typically malignant tumor in the digestive system. The mortality of HCC ranks third place in the world, second only to lung cancer and colorectal cancer. For the characteristics of high invasiveness, high metastasis, high recurrence rate as well as short survival time, HCC treatment has always been difficult in clinical practice. Many causes have contributed to the appearance of these features, including insidious onset, high degree of malignancy, lack of effective early molecular diagnostic markers, and disease prediction models. The human chemokine-like factor superfamily (CMTMs) is a new gene family consisting of CKLF and CMTM1-CMTM8. CMTMs have a marvel domain which can activate and chemotaxis immune cells. Many studies have reported that CMTMs are involved in the regulation of cell growth and development, and play an important role in the malignant progression of the immune system and reproductive system, especially in the development of tumors. In this review, we summarized the structure and function of the human CMTMs, the relationship between its family members and HCC, the prognostic value, potential functions, and mechanisms in HCC. CMTMs could provide a new diagnostic and therapeutic target in clinical practice for patients with HCC.
The influence of cultural identity education on students’ positive psychology

The aim of this study was to Analysed the influence of Chinese traditional culture identity education on the positive psychology of university students. The study selected 200 students as the research object and divided into experimental group and control group. The students in the experimental group received traditional cultural identity education courses combined with practical activities, while the control group implemented conventional courses. After implementing the program, students’ learning efficiency is significantly improved and their learning anxiety is reduced. The learning effectiveness, cultural identity, and interpersonal communication barriers of the experimental group students have all improved, and the improvement in positive psychological status of the experimental group is significantly higher than that of the control group. The difference between the two groups is statistically significant. Chinese culture has a long history and contains profound life truth and positive thoughts. Good traditional cultural identity education can cultivate college students’ correct political position and establish correct outlook on life, values and the world. This study showed effective cultural identity education and practical activities in colleges and universities can effectively promote the cultivation of students’ positive psychology, improve students’ self-confidence and enhance national pride.Contribution: The result of this study is applicable for scholars in the field of psychology of religion and the sociology of religion, as well as cultural studies and public theology.
Scalable Reasoning on Document Stores via Instance-Aware Query Rewriting

Data trees, typically encoded in JSON, are ubiquitous in data-driven applications. This ubiquity makes urgent the development of novel techniques for querying heterogeneous JSON data in a flexible manner. We propose a rule language for JSON, called constrained tree-rules, whose purpose is to provide a high-level unified view of heterogeneous JSON data and infer implicit information. As reasoning with constrained tree-rules is undecidable, we identify a relevant subset featuring tractable query answering, for which we design an automata-based query rewriting algorithm. Our approach consists of leveraging NoSQL document stores by means of a novel instance-aware query-rewriting technique. We present an extensive experimental analysis on large collections of several million JSON records. Our results show the importance of instance-aware rewriting as well as the efficiency and scalability of our approach.
Enhancing NOMA Backscatter IoT Communications With RIS

As potential solutions to empower transmissions among the Internet of Things (IoT) devices, ambient radio frequency (RF) backscatter technology and reconfigurable intelligent surfaces (RISs) have recently attracted a lot of attention. To improve energy and spectrum efficiency, we design a system with a transmit antenna selection (TAS)-aided base station (BS) relying on nonorthogonal multiple access (NOMA), RIS, and backscatter communications (BackCom) with robust transmission links, allowing more users to be served effectively. We adopt the two-user grouping model in the coverage of main BS associated with a particular RIS and interference from coordinate BS is also considered to showcase differences among the performance of the two different kinds of users (i.e., the IoT user with and the IoT user without a dedicated RIS). To exhibit the system performance, we derive closed-form expressions for two main system performance metrics, namely, outage probability and ergodic capacity. A degraded performance is also considered for the case of imperfect successive interference cancellation (SIC). The benefits of the BackCom RIS-aided NOMA system are then demonstrated by comparing its performance to that of traditional orthogonal multiple access (OMA) RIS-aided backscatter systems. We then introduce analytical models to characterize the impact of the main factors on the outage performance and characterize the optimal performance in specific cases. Together with extensive simulations, our analysis shows that the system performance can be adjusted by controlling factors, including power allocation coefficients, the number of metasurfaces of RIS, and target rates.
Social Complexity in the Southern Levantine Ppnb as Reflected Through Lithic Studies: The Bidirectional Blade Industries

The aims of this research are two-fold. First is to present and systematically analyze the bidirectional flint blade industries from PPNB sites throughout the southern Levant. The other aim is to examine two of the models discussed, Regionalism and Craft specialization. With regards to Regionalism the author examines whether the proposed cultural units for the southern Levant region are also reflected in the bidirectional blade industries. The issue of Craft specialization is examined to consider whether complex lithic economies such as the one described for Ain Ghazal can be identified at other sites in the southern Levant.
Effects of referential structure on pronoun interpretation

ABSTRACT Pronoun interpretation is guided by various factors. While most previously-investigated factors involve properties occurring before the pronoun, less attention has been paid to properties of the pronoun-containing clause. We investigate whether pronoun interpretation is influenced by the referential structure of the pronoun-containing clause (i.e. whether another referent from the preceding clause is mentioned), which contributes to discourse coherence. We report three experiments showing referential structure effects: whether subject-position pronouns are ultimately interpreted as referring to the preceding subject or object depends on whether the clause contains another pronoun (e.g. she called Lisa vs. she called her). More specifically, subject-position pronouns exhibit a stronger object preference when only one of the prior antecedents is mentioned, compared to when both are mentioned. We show that this effect is separate from effects of verb semantics and cannot be reduced to semantic or syntactic parallelism effects. Implications for models of pronoun resolution are discussed.
Was there a nonglacial episode in the western Hudson Bay Lowland during Marine Isotope Stage 3?

Abstract Establishing the timing of glacial and nonglacial intervals in the core regions of the Laurentide Ice Sheet (LIS) is essential to constrain ice-sheet configuration at times of globally reduced ice volume, such as during Marine Isotope Stage (MIS) 3 (~57–29 ka). Hudson Bay Lowland (HBL) deglaciation, at the centre of the LIS, has been inferred at MIS 3 based on near-infinite wood radiocarbon ages and limited luminescence ages. To better constrain the age of the penultimate deglaciation of the western HBL, this study initially identified the youngest intertill nonglacial sediments, based on extensive fieldwork and till characterization. Next, vetted radiocarbon ages were combined with revised stratigraphy to show that five previously identified “MIS 3” sites were likely deposited during an earlier ice-free period. Finally, new optical ages targeting the youngest intertill nonglacial bed at three localities yielded ages ranging from 166 to 146 ka; all older than MIS 3. These ages indicate that the penultimate deglaciation of the western HBL likely occurred during MIS 5e. This interpretation better explains accompanying paleobotanic data sets that indicate vegetation similar to vegetation existing under present interglacial conditions. Currently no firm evidence exists in the terrestrial stratigraphic record for the deglaciation of the western HBL during MIS 3.