Miracle-dz/UniFAR-FTUs huggingface dataset:
Antibiotic and antifungal use in pediatric leukemia and lymphoma patients are associated with increasing opportunistic pathogens and decreasing bacteria responsible for activities that enhance colonic defense

Due to decreased immunity, both antibiotics and antifungals are regularly used in pediatric hematologic-cancer patients as a means to prevent severe infections and febrile neutropenia. The general effect of antibiotics on the human gut microbiome is profound, yielding decreased diversity and changes in community structure. However, the specific effect on pediatric oncology patients is not well-studied. The effect of antifungal use is even less understood, having been studied only in mouse models. Because the composition of the gut microbiome is associated with regulation of hematopoiesis, immune function and gastrointestinal integrity, changes within the patient gut can have implications for the clinical management of hematologic malignancies. The pediatric population is particularly challenging because the composition of the microbiome is age dependent, with some of the most pronounced changes occurring in the first three years of life. We investigated how antibiotic and antifungal use shapes the taxonomic composition of the stool microbiome in pediatric patients with leukemia and lymphoma, as inferred from both 16S rRNA and metagenome data. Associations with age, antibiotic use and antifungal use were investigated using multiple analysis methods. In addition, multivariable differential abundance was used to identify and assess specific taxa that were associated with multiple variables. Both antibiotics and antifungals were linked to a general decline in diversity in stool samples, which included a decrease in relative abundance in butyrate producers that play a critical role in host gut physiology (e.g., Faecalibacterium, Anaerostipes, Dorea, Blautia),. Furthermore, antifungal use was associated with a significant increase in relative abundance of opportunistic pathogens. Collectively, these findings have important implications for the treatment of leukemia and lymphoma patients. Butyrate is important for gastrointestinal integrity; it inhibits inflammation, reinforces colonic defense, mucosal immunity. and decreases oxidative stress. The routine use of broad-spectrum anti-infectives in pediatric oncology patients could simultaneously contribute to a decline in gastrointestinal integrity and colonic defense while promoting increases in opportunistic pathogens within the patient gut. Because the gut microbiome has been linked to both short-term clinical outcomes, and longer-lasting health effects, systematic characterization of the gut microbiome in pediatric patients during, and beyond, treatment is warranted.
Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction

Pneumolysin (PLY) is a bacterial pore forming toxin and primary virulence factor of Streptococcus pneumonia, a major cause of pneumonia. PLY binds cholesterol-rich domains of the endothelial cell (EC) plasma membrane resulting in pore assembly and increased intracellular (IC) Ca2+ levels that compromise endothelial barrier integrity. Caveolae are specialized plasmalemma microdomains of ECs enriched in cholesterol. We hypothesized that the abundance of cholesterol-rich domains in EC plasma membranes confers cellular susceptibility to PLY. Contrary to this hypothesis, we found increased PLY-induced IC Ca2+ following membrane cholesterol depletion. Caveolin-1 (Cav-1) is an essential structural protein of caveolae and its regulation by cholesterol levels suggested a possible role in EC barrier function. Indeed, Cav-1 and its scaffolding domain peptide protected the endothelial barrier from PLY-induced disruption. In loss of function experiments, Cav-1 was knocked-out using CRISPR-Cas9 or silenced in human lung microvascular ECs. Loss of Cav-1 significantly enhanced the ability of PLY to disrupt endothelial barrier integrity. Rescue experiments with re-expression of Cav-1 or its scaffolding domain peptide protected the EC barrier against PLY-induced barrier disruption. Dynamin-2 (DNM2) is known to regulate caveolar membrane endocytosis. Inhibition of endocytosis, with dynamin inhibitors or siDNM2 amplified PLY induced EC barrier dysfunction. These results suggest that Cav-1 protects the endothelial barrier against PLY by promoting endocytosis of damaged membrane, thus reducing calcium entry and PLY-dependent signaling.
On the value of satellite remote sensing to reduce uncertainties of regional simulations of the Colorado River

Abstract. As the major water resource in the southwestern United States, the Colorado River is experiencing decreases in naturalized streamflow and is predicted to face severe challenges under future climate scenarios. To better quantify these hydroclimatic changes, it is crucial that the scientific community establishes a reasonably accurate understanding of the spatial patterns associated with the basin hydrologic response. In this study, we employed remotely sensed land surface temperature (LST) and snow cover fraction (SCF) data from the Moderate Resolution Imaging Spectroradiometer (MODIS) to assess a regional hydrological model applied over the Colorado River Basin between 2003 and 2018. Based on the comparison between simulated and observed LST and SCF spatiotemporal patterns, a stepwise strategy was implemented to enhance the model performance. Specifically, we corrected the forcing temperature data, updated the time-varying vegetation parameters, and upgraded the snow-related process physics. Simulated nighttime LST errors were mainly controlled by the forcing temperature, while updated vegetation parameters reduced errors in daytime LST. Snow-related changes produced a good spatial representation of SCF that was consistent with MODIS but degraded the overall streamflow performance. This effort highlights the value of Earth observing satellites and provides a roadmap for building confidence in the spatiotemporal simulations from regional models for assessing the sensitivity of the Colorado River to climate change.
Group therapy for bulimics: Implications for school counselors Group therapy for bulimics: Implications for school counselors

Abstract " Although our society has become increasingly preoccupied with eating and weight, it is only relatively recently that publicity has been given to eating disorders such as anorexia nervosa and bulimia" (Hendrick, 1985, p. 275). For purposes of this paper, the author is only going to deal with bulimia. Bulimia has primarily been a concern among college-age women, but over the past decade the prevalence of the disorder has increased dramatically among adolescent females (Omizo & Omizo, 1992). The increasing incidence of bulimia warrants concern for those professionals working with adolescents, such as school counselors and therapists in private practice or agencies. Since bulimia is a "serious disorder that can have a drastic impact on the quality and direction of an individual's life" (Butterfield, McKay, Peters, & Swassing, 1984, p. 183), it is important to learn what can be done to prevent this disorder and which treatment modes are most effective with this population.
Thermal Models for Box Type Windows: Part 1

Techniques for the thermal modelling of contemporary single skin windows with insulating glass units are well developed, but their applicability for traditional box type windows is under investigated. Due to their different construction and dimensions, a different type of natural convection is encountered in their air cavity. In this article, a literature review is conducted to analyse the characteristics of this flow and its difference from the flows in contemporary windows. Finally, the best-known correlations used to quantify the convective heat transfer in glazing cavities are analysed with regards to their validity for the specific case of box type windows.
Comment on egusphere-2022-208

The manuscript by Ou presents a theory of abrupt glacial climate changes. The author postulates that Heinrich and Dansgaard-Oeschger events have the same nature and are related to abrupt changes in the ice calving into the ocean. In fact, the idea that abrupt climate changes of the glacial age were related to strongly variable freshwater flux into the ocean is by far not new, although one of many and not the most popular now. The only novelty of the proposed theory is that, according to the author, abrupt climate changes do “not involve ocean mode change, as commonly assumed“ (L. 11). Although the author repeated this statement a dozen times, he did not explain what he understands under “mode change”, and this is why it is difficult to assess how much the mechanisms proposed by the author differ from those that have been proposed in numerous previous studies.
Nonpharmacological Applications During the Retinopathy of Prematurity Examination and Their Effects on Pain Control

Examination for retinopathy of prematurity (ROP) is a very painful procedure. Therefore, pain management is essential given the possibility of sensory and behavioral problems in newborns, who are constantly exposed to painful stimuli. In this light, the use of nonpharmacological methods alone or in combination with pharmacological methods is recommended for pain control. This systematic review and meta-analysis was to evaluate the effects of nonpharmacological treatments on pain during ROP examination. Randomized controlled trials published in English between 2011 and 2021 and available in the electronic databases of Medline, Web of Science, Nursing & Allied Health, and PubMed were reviewed. The meta-analysis was performed using Review Manager 5.4. Six randomized controlled studies were included. Glucose (mean difference [MD]: −1.64, 95% confidence interval [CI]: −2.34 to 0.94, P < .0001) and sucrose (MD: −2.50, 95% CI: −3.20 to −1.79, P < .0001) solutions were effective in reducing pain. However, breast milk did not reduce the Premature Infant Pain Profile score (MD: −2.50, 95% CI: −6.10 to 1.10, P > .05). The application of sucrose and glucose solutions for pain management during ROP examination can be effective and safe.
Progress in the management of patients with diabetes and chronic kidney disease

Purpose of review Diabetic kidney disease is the most common cause of chronic kidney disease (CKD) and end-stage kidney disease in the world. Risk factor modification, glucose control, and renin–angiotensin–aldosterone system blockade have remained the standard of care for 2 decades. New therapeutic agents have emerged in recent years, demonstrating kidney and cardiovascular benefits, and herein we review recent clinical trials on this topic. Recent findings After the publication of several cardiovascular outcome trials for sodium–glucose cotransporter 2 inhibitors (SGLT-2i), new trials have focused ON primary kidney-specific outcomes demonstrating safety and benefits among patients with proteinuric CKD; patients with or without diabetes, and heart failure with preserved ejection fraction (HFpEF) respectively. Similarly, nonsteroidal mineralocorticoid receptor antagonists (ns-MRAs) and glucagon-like-peptide 1 receptor agonists (GLP-1 RAs) have improved cardiovascular and kidney outcomes. Recently, clinical practice guidelines have also been updated to reflect this new evidence. Summary In summary, SGLT-2i, GLP-1 RAs, and ns-MRAs have demonstrated cardiovascular and kidney benefits, including all-cause and cardiovascular mortality, progression to end-stage kidney disease, and hospitalizations for heart failure exacerbation among diverse patient population.
Goal-Setting characteristics of Nutrition-Related mHealth Systems: a Morphological Analysis

Setting and pursuing goals plays a major role in health behavior change. As an elementary component of interventions and mHealth apps, goals can support people in pursuing and attaining a desired outcome or behavior. Despite its widespread use and indicated effects on behavioral performance, there is no guidance on how to design and implement goal setting, planning and evaluation for mHealth nutrition promotion. We investigate goal setting and related components in the context of mHealth and health behavior change in a structured literature review. By utilizing morphological analysis, we develop a design framework for goal setting and pursuit. We validate and refine the framework by application on popular commercial nutrition apps. As a result, we identify the coverage of goal-setting and -pursuit characteristics as well as current gaps in the implementation of commercial mHealth nutrition apps, which offer the potential for future effective development of goal setting in mHealth nutrition promotion.
Effects of Acute Aquatic High-Intensity Intermittent Exercise on Blood Pressure and Arterial Stiffness in Postmenopausal Women with Different ACE Genotypes

The present study investigated the effects of acute aquatic high-intensity intermittent jumping (HIIJ) on blood pressure (BP) and arterial stiffness in postmenopausal women with different angiotensin-converting enzyme genotypes (ACE). We recruited 12 postmenopausal women carrying the ACE deletion/deletion (DD) genotype and 61 carrying the insertion/insertion or insertion/deletion (II/ID) genotype. The participants performed 12 trials of 30 s, 75% heart rate reserve (HRR) jumping, and 60 s, 50% HRR recovery, and 3 trials of 40 s upper limb resistance exercises were performed as fast as possible. The heart rate (HR) and BP were measured before exercise, immediately, 10 min, and 45 min after exercise. The brachial-ankle pulse wave velocity (baPWV) was measured before and after exercise. The systolic blood pressure (SBP) of the DD genotype increased more significantly than those with the II/ID genotype post-exercise (30.8 ± 4.48 vs. 20.4 ± 2.00 mmHg, p = 0.038). The left and right sides of baPWV increased significantly after exercise (1444.8 ± 29.54 vs. 1473.4 ± 32.36 cm/s, p = 0.020; 1442.1 ± 30.34 vs. 1472.0 ± 33.09, p = 0.011), and there was no significant difference between the two groups. The HIIJ increased baPWV. The postmenopausal women with the DD genotype have a higher SBP increased post-exercise than those with II/ID genotype. These findings suggest that the aquatic exercise program has better effects in decreasing blood pressure in postmenopausal women with the II/ID genotype. Those with the DD genotype should pay attention to the risk of increasing blood pressure after aquatic HIIJ exercise.
Investigating the Relationship between Facial Mimicry and Empathy

Facial expressions play a key role in interpersonal communication when it comes to negotiating our emotions and intentions, as well as interpreting those of others. Research has shown that we can connect to other people better when we exhibit signs of empathy and facial mimicry. However, the relationship between empathy and facial mimicry is still debated. Among the factors contributing to the difference in results across existing studies is the use of different instruments for measuring both empathy and facial mimicry, as well as often ignoring the differences across various demographic groups. This study first looks at the differences in the empathetic abilities of people across different demographic groups based on gender, ethnicity and age. The empathetic ability is measured based on the Empathy Quotient, capturing a balanced representation of both emotional and cognitive empathy. Using statistical and machine learning methods, this study then investigates the correlation between the empathetic ability and facial mimicry of subjects in response to images portraying different emotions displayed on a computer screen. Unlike the existing studies measuring facial mimicry using electromyography, this study employs a technology detecting facial expressions based on video capture and deep learning. This choice was made in the context of increased online communication during and after the COVID-19 pandemic. The results of this study confirm the previously reported difference in the empathetic ability between females and males. However, no significant difference in empathetic ability was found across different age and ethnic groups. Furthermore, no strong correlation was found between empathy and facial reactions to faces portraying different emotions shown on a computer screen. Overall, the results of this study can be used to inform the design of online communication technologies and tools for training empathy team leaders, educators, social and healthcare providers.
The Effect of Acute Administration of the Aqueous Calyx Extract of Hibiscus sabdariffa on Blood pressure, Heart rate and Double Product of Apparently Healthy Human Subjects during Different Postures.

The aqueous calyx extract of Hibiscus sabdariffa (HS) is widely consumed as a beverage in Northern Nigeria and other parts of the world. HS has been reported to lower blood pressure (BP) in animals and man. However, not much is known about the effect of HS on BP in different postures. We tested the hypothesis that HS may lower BP, heart rate (HR) and heart rate-pressure product or double product (DP) by attenuating the discharge of the autonomic nervous system in different postures. Experiments were performed in accordance with the Principles of the Declaration of Helsinki. Following ethical approval and informed consent, BP and HR were measured in different postures (supine, sitting and standing) in apparently healthy human subjects (n=20) before and after (+HS) the oral administration of 15mg/Kg HS. Mean arterial pressure (MAP; taken as representative BP) and DP were calculated. Results are expressed as mean ±SEM. Paired t test and ANOVA with a post hoc Bonferroni test were used for statistical analyses. P<0.05 was considered significant. In the supine position MAP, HR and DP were significantly (P<0.0001 each) reduced in the presence of HS (85.6±1.7mmHg, 72.1±1.1/min and 8716±320mmHg.bpm) compared to its absence (89.6±2.0mmHg, 73.7±1.6/min and 8921±444mmHg.bpm). Similar trends were observed in the sitting position in the presence of HS (85.4±2.7mmHg, 73.7±1.8/min and 9098±345mmHg.bpm vs its absence: 91.4±2.3mmHg, 77.1±1.9/min and 9388±478mmHg.bpm; P<0.0001, P<0.0001 and P=0.007 respectively) and in the standing position (+HS: 89.3±2.0mmHg, 78.1±1.8/min and 10164±230mmHg.bpm vs its absence: 94.3±2.1mmHg, 81.8±2.3/min and 10742±268mmHg.bpm; P<0.0001, P<0.0001 and P=0.007 respectively). In the absence of HS, HR and DP were significantly higher in the standing posture (81.8±2.3/min, 10742±268mmHg.bpm) compared to the sitting (77.1±1.9/min, 9388±478mmHg.bpm; P<0.05 and P<0.0001 respectively) and the supine (73.7±1.6/min, 8921±444mmHg.bpm; P<0.001 each) postures while the BP remained similar. A similar trend was observed across the three postures in the presence of HS although the parameters were significantly lower. It is concluded that HS lowered BP, HR and DP by modulating autonomic mechanisms through the inhibition of both parasympathetic withdrawal and sympathetic nervous system discharge across the postures. Also the standing posture is associated more with a higher sympathetic nervous system discharge and a higher cardiac oxygen demand and workload than the sitting and supine postures in the absence or presence of HS.
Electric Field and Its Effect on Hot Carriers in InGaAs Valley Photovoltaic Devices

Power- and bias-dependent photoluminescence measurements are performed on devices with 25 and 100 nm InGaAs absorber layers to study the influence of the electric field on the maintenance and temperature of hot-carrier populations in valley photovoltaic III–V heterostructures. Photoluminescence and current density versus voltage measurements indicate that the electric field increases the hot-carrier temperature as a result of its role in accelerating low-energy carriers to the upper valleys. The net result of this behavior is a power-dependent hot phonon bottleneck at all fluences irrespective of absorbed power with a nonzero power-independent hot-carrier population.
I SURVIVED CANCER: PHENOMENOLOGICAL ANALYSIS OF THE SURVIVORS' LANGUAGE

Buscamos comprender los sentimientos de personas que sobrevivieron al cancer, por medio de la investigacion cualitativa e abordaje fenomenologica heideggeriana. Fueron sujetos cinco sobrevivientes de cancer, acompanados entre los anos de 2004 y 2005 por un proyecto de extension en el Noroeste de Parana. Para captar los sentimientos de los sobrevivientes fue usada la entrevista fenomenologica. Las personas fueron entrevistadas, en el propio domicilio, entre los meses de enero a febrero de 2013, con la siguiente cuestion: "? Como es para usted haber sobrevivido al cancer? " Emergieron cuatro tematicas ontologicas: (Re) Acordandose el vigor de haber sido; (Re) Encontrandose con la espiritualidad; Temiendo la recidiva de la enfermedad; Olvidandose de la temporalidad de existir con cancer. Llegamos a la conclusion que, en su ser-sanado, los pacientes viven con la angustia, que lanza en un estado penoso, por temor a la recurrencia, asi como permite encontrar un nuevo sentido a la vida.
The Pt(S-pr-thiosal)2 and BCL1 Leukemia Lymphoma: Antitumor Activity In Vitro and In Vivo

B cell malignancies are, despite the development of targeted therapy in a certain percentage of the patients still a chronic disease with relapses, requiring multiple lines of therapy. Regimens that include platinum-based drugs provide high response rates in different B cell lymphomas, high-risk chronic lymphocytic leukemia (CLL), and devastating complication of CLL, Richter’s syndrome. The aim of this study was to explore the potential antitumor activity of previously synthetized platinum(IV) complex with alkyl derivatives of thyosalicilc acid, PtCl2(S-pr-thiosal)2, toward murine BCL1 cells and to delineate possible mechanisms of action. The PtCl2(S-pr-thiosal)2 reduced the viability of BCL1 cells in vitro but also reduced the growth of metastases in the leukemia lymphoma model in BALB/c mice. PtCl2(S-pr-thiosal)2 induced apoptosis, inhibited proliferation of BCL1 cells, and induced cell cycle disturbance. Treatment of BCL1 cells with PtCl2(S-pr-thiosal)2 inhibited expression of cyclin D3 and cyclin E and enhanced expression of cyclin-dependent kinase inhibitors p16, p21, and p27 resulting in cell cycle arrest in the G1 phase, reduced the percentage of BCL1 cells in the S phase, and decreased expression of Ki-67. PtCl2(S-pr-thiosal)2 treatment reduced expression of phosphorylated STAT3 and downstream-regulated molecules associated with cancer stemness and proliferation, NANOG, cyclin D3, and c-Myc, and expression of phosphorylated NFκB in vitro and in vivo. In conclusion, PtCl2(S-pr-thiosal)2 reduces STAT3 and NFκB phosphorylation resulting in inhibition of BCL1 cell proliferation and the triggering of apoptotic cell death.