Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of the Pathogenic Effect of IGHMBP2 Gene Mutations Based on Yeast S. cerevisiae Model

Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a heritable neurodegenerative disease characterized by rapid respiratory failure within the first months of life and progressive muscle weakness and wasting. Although the causative gene, IGHMBP2, is well defined, information on IGHMBP2 mutations is not always sufficient to diagnose particular patients, as the gene is highly polymorphic and the pathogenicity of many gene variants is unknown. In this study, we generated a simple yeast model to establish the significance of IGHMBP2 variants for disease development, especially those that are missense mutations. We have shown that cDNA of the human gene encodes protein which is functional in yeast cells and different pathogenic mutations affect this functionality. Furthermore, there is a correlation between the phenotype estimated in in vitro studies and our results, indicating that our model may be used to quickly and simply distinguish between pathogenic and non-pathogenic mutations identified in IGHMBP2 in patients.
Convergence of different linear and non-linear Vicsek models

The Vicsek model describes the evolution of a system composed by different agents moving in the plane. Each agent has a constant speed and updates its heading using a local rule depending on the headings of its “neighbors”. Although the original model by Vicsek is non-linear, most of the convergence results obtained so far deal with linearized versions. In this paper, we introduce a new linear model in which the relative importance of each neighbor can vary with the distance and we prove the convergence of all the agents headings. For this purpose, we derive a theorem on the convergence of long products of stochastic products that applies to infinite set of matrices. Using this result we also prove convergence properties for the original non-linear Vicsek model. Moreau [7] obtains similar results to ours but using a proof technique based on convexity and system theory. We present here proofs that are based on elementary linear algebra tools. The results we obtain are somewhat weaker than those of Moreau but have the advantage of being indistinctly applicable to continuous and discontinuous systems.
Effect of herbicides on distribution and interference of weeds, growth and yield of wheat (Triticum aestivum) in Kandahar, Afghanistan

Weeds are the major constraint to achieving higher wheat yield in Afghanistan. To evaluate weed interference and its impact on wheat, a field experiment was undertaken during winter season in 2014–15 at Afghanistan National Agricultural Science and Technology University (ANASTU), Kandahar. Seven weed control treatments comprising isoproturon 0.75 and 1.0 kg/ha at 35 days after sowing (DAS), sulfosulfuron 20 and 25 g/ha at 35 DAS, isoproturon + 2,4-D 0.75 + 0.5 kg/ha at 35 DAS (tank-mix), weed-free check and weedy check were laid out in a randomized complete block design with three replications. Results showed that grassy weeds constituted 62.7% of the total weeds and were mostly dominant. All herbicides/weed control treatments influenced weed interference, wheat cropgrowth and yield significantly. Sulfosulfuron 25 g/ha at 35 DAS resulted in significant reduction in weed density by 95.2% (i.e. weed control efficiency) and dry weight by 95.1% (i.e. weed control index), respectively. This treatment led to significant improvements in wheat growth (Leaf area index, dry matter accumulation) and grain (4.6 t/ha) and biological yields (10.6 t/ha), and was superior to other herbicide treatments. It increased wheat grain and biological yields by 24.3% and 17.8%, respectively, compared to weedy check. Therefore, the application of sulfosulfuron 25 g/ha at 35 DAS may be recommended for better weed control and higher wheat yield in Kandahar, Afghanistan, and in similar agro-ecologies of the tropics and sub-tropics.
Student Factors and Parental Involvement on Academic Performance of Senior Secondary School Students Qualifying Examination in Osun State Secondary Schools

The study examined Osun State senior secondary school students’ performance identified factors that affect senior secondary school students’ performance, and factors contributing to students’ performance. The study adopted the descriptive survey research design. The population of the study comprised all 243 public senior secondary schools in Osun State. A sample of 600 Senior Secondary Two (SS II) students was selected using a multistage sampling procedure. The instruments used for data collection were questionnaire and pro-forma. Three forms of the questionnaire were used; they are Questionnaire on Student Factors and Parental Involvement on Academic Performance designed for students in secondary schools (QSFPIAPSSS), Questionnaire on Academic Performance designed for secondary school teachers (QAPSST), Questionnaire on Academic Performance designed for secondary school administrators (QAPSSA). The pro-forma on students’ academic performance in 2017 qualifying examination was used to collect academic performance record. The data collected were analyzed using frequency, counts and multiple regression. The results showed that 12.2% of the students sampled had low-level academic performance, while 10.2% of them had high-level academic performance. Results also showed that study habit (18.6%), self-efficacy (16.8%), parental care (47.6%) and teachers’ influence (36.3%) significantly affect students’ academic performance. The study concluded that students’ habit, self-efficacy, parental care and teachers’ influence were the strongest factors that contribute significantly to students’ academic performance in qualifying examination in Osun State Secondary Schools.
Usage of Vitamin D Supplements During Covid19 Pandemic in Baghdad City, Iraq

Background: The aim of the current study is to determine vitamin D supplement usage among adults living in Baghdad city, Iraq during COVID19 pandemic. Methods: A cross-sectional study was conducted among 480 adults living in Baghdad city, Iraq through convince sampling. An online administered questionnaire was used to collect the data from respondents. Results: Around two-thirds of respondents used Vitamin D supplements (65%). There was a significant association between taking Vitamin D3 supplements and educational level, getting COVID19 infection with P value of (0.01, <0.001, <0.001) respectively. Conclusion: As a conclusion, two-thirds of our study respondents took Vitamin D supplements during COVID19 pandemic. More education is needed for population about the use of vitamin D in boosting immunity and preventing infections.
Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance

Regardless of the significant improvements in treatment of melanoma, the majority of patients develop resistance whose mechanisms are still not completely understood. Hence, we generated and characterized two melanoma-derived cell lines, primary WM793B and metastatic A375M, with acquired resistance to the RAF inhibitor vemurafenib. The morphology of the resistant primary WM793B melanoma cells showed EMT-like features and exhibited a hybrid phenotype with both epithelial and mesenchymal characteristics. Surprisingly, the vemurafenib-resistant melanoma cells showed a decreased migration ability but also displayed a tendency to collective migration. Signaling pathway analysis revealed the reactivation of MAPK and the activation of the PI3K/AKT pathway depending on the vemurafenib-resistant cell line. The acquired resistance to vemurafenib caused resistance to chemotherapy in primary WM793B melanoma cells. Furthermore, the cell-cycle analysis and altered levels of cell-cycle regulators revealed that resistant cells likely transiently enter into cell cycle arrest at the G0/G1 phase and gain slow-cycling cell features. A decreased level of NME1 and NME2 metastasis suppressor proteins were found in WM793B-resistant primary melanoma, which is possibly the result of vemurafenib-acquired resistance and is one of the causes of increased PI3K/AKT signaling. Further studies are needed to reveal the vemurafenib-dependent negative regulators of NME proteins, their role in PI3K/AKT signaling, and their influence on vemurafenib-resistant melanoma cell characteristics.
Visuotactile Peripersonal Space in Healthy Humans: Evidence from Crossmodal Congruency and Redundant Target Effects

Single neuron studies on monkeys provided convincing evidence for the existence of visuotactile peripersonal space. The range of this space was operationally deﬁned as a space where visuotactile interactions occurred at the neuronal level, and the distance between the body part and visual stimuli was a crucial factor. While the functional similarities in humans were mainly evidenced by studies with patients with right brain damage exhibiting extinction, less is known about the same in healthy adults. The present study demonstrated the existence of visuotactile peripersonal space in healthy adults using two psychophysical measurements. In Experiment 1, participants discriminated the location of vibrotactile target stimuli presented on their left or right hand, while trying to ignore visual distractors that were independently presented close to or away from the tactile stimuli, either on the same side as the target stimulus or on the opposite side (visuotactile congruency task). Results showed that crossmodal congruency eﬀects were greater when visual stimuli were in proximity to the hands, rather than away from them. In Experiment 2, redundant target eﬀects were measured by using a go/no-go paradigm where participants produced speeded responses all to randomized sequence of unimodal (visual or tactile) and simultaneous visuotactile targets presented in one hemispace, while ignoring tactile stimuli presented in the other hemispace. Visual targets were presented either close to or away from the hand. Results showed that the statistical facilitation model was violated (i.e., the coactivation model was supported) only when visual stimuli were presented in proximity to the stimulated hand. These results suggest that visuotactile peripersonal space was distinctly and modularly represented in healthy human brains.
A new 3‐D spherical hybrid model for solar wind interaction studies

A 3‐D spherical hybrid model has been developed to study how the solar wind interacts with various solar system bodies. The main advantages of the new spherical model, called the HYB‐s, compared with traditional Cartesian models are that the spherical model allows significantly reduced radial cell size and, consequently, a smaller total number of cells and particles in the simulation. The high radial resolution makes it possible to use the new model for 3‐D physical studies that have not been feasible before. Especially, the spherical model allows the inclusion of self‐consistent ionospheric photochemistry in global hybrid simulations of the solar wind interaction with terrestrial planets Venus and Mars. In this paper we describe the main aspects of the developed spherical hybrid model. We also study the solar wind interaction with Venus in a global hybrid simulation using the spherical hybrid model and our already published Cartesian hybrid model. The comparison between the two models suggests the high potential of the developed spherical hybrid model in studies of planetary plasma interactions.
Respiratory Symptoms and Skin Sick Building Syndrome among Office Workers at University Hospital, Chiang Mai, Thailand: Associations with Indoor Air Quality, AIRMED Project

Sick building syndrome (SBS) is the term used to describe the medical condition in which people in a building suffer from symptoms of illnesses for no apparent reason. SBS was found to be associated with indoor air quality (IAQ) but there are a variety of determinants (buildings, in particular). Identifying and controlling factors related to SBS is crucial for improving worker health and efficiency. A cross-sectional study was conducted to investigate (1) the prevalence of respiratory symptoms and skin SBS and (2) their associations with IAQ among office workers in administrative offices in an academic medical institute. A self-reporting questionnaire assessing the worker’s characteristics, working conditions, and perception of working environments was used. The building assessment was via a walk-through survey and IAQ measurement. Of 290 office workers, 261 (90%) in 25 offices of 11 buildings took part in the survey. The highest prevalence of SBS was nasal symptoms (25.3%). We found that to reduce the risk of SBS, optimal air temperature levels in air-conditioned offices should be lower than 23 °C, with relative humidity between 60% and 70%. Lowering indoor CO2 levels below 700 ppm may be indicative of adequate ventilation to prevent SBS by reducing worker discomfort and indoor contaminants (e.g., formaldehyde).
The coordination of green–brown food webs and their disruption by anthropogenic nutrient inputs

Abstract Aim Our goal was to quantify nitrogen flows and stocks in green–brown food webs in different ecosystems, how they differ across ecosystems and how they respond to nutrient enrichment. Location Global. Time period Contemporary. Major taxa studied Plants, phytoplankton, macroalgae, invertebrates, vertebrates and zooplankton. Methods Data from >500 studies were combined to estimate nitrogen stocks and fluxes in green–brown food webs in forests, grasslands, brackish environments, seagrass meadows, lakes and oceans. We compared the stocks, fluxes and metabolic rates of different functional groups within each food web. We also used these estimates to build a dynamical model to test the response of the ecosystems to nutrient enrichment. Results We found surprising symmetries between the green and brown channels across ecosystems, in their stocks, fluxes and consumption coefficients and mortality rates. We also found that nitrogen enrichment, either organic or inorganic, can disrupt this balance between the green and brown channels. Main conclusions Linking green and brown food webs reveals a previously hidden symmetry between herbivory and detritivory, which appears to be a widespread property of natural ecosystems but can be disrupted by anthropogenic nitrogen additions.
Characterization of Argentinian Honeys Based on their Sugar Profiles and Quality Parameters

1CIAS-IIPROSAM, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3350, B7602AYL Mar del Plata, Argentina 2Agencia Nacional de Promoción Científica y Tecnológica, Godoy Cruz 2370, C1425FQD Buenos Aires, Argentina 3Nexco S.A. , Viamonte 773, C1053ABO Buenos Aires, Argentina 4Instituto Superior del Profesorado en Ciencias Agrarias y Protección Ambiental (PROCAyPA), Ministerio del Agro y la Producción de la Provincia de Misiones (MAyP), José Manuel Estrada 210, N3332 Capioví, Misiones, Argentina 5Comisión Investigaciones Científicas de la Provincia de Buenos Aires (CIC), Calle 526, B1900 La Plata, Argentina 6Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, C1425FQB Buenos Aires, Argentina
Finiteness of entanglement entropy in a quantum black hole

A logarithmic but divergent term usually appears in the computation of entanglement entropy circumferencing a black hole, while the leading quantum correction to the Bekenstein-Hawking entropy also takes the logarithmic form. A quench model of CFT within finite Euclidean time was proposed by Kuwakino and Wen (JHEP, 05 (2015) 099) to regard this logarithmic term as entanglement between radiation and the black hole, and this proposal was justified by the alternative sign for n-partite quantum information. However, this preliminary form suffers from the notorious divergence at its low-temperature limit. In this letter, we propose a modified form for black-hole entanglement entropy such that the divergence sickness can be cured. We discuss the final stage of a black hole due to this modification and its relation to the Rényi entropy, higher-loop quantum correction and higher-spin black holes.
Trace Elements in Beef Cattle: A Review of the Scientific Approach from One Health Perspective

Simple Summary This review seeks to understand how scientific research on trace elements in beef cattle has been developed and how the interaction of this theme with topics related to animal, environmental and human health has been established. Given the duality of many of the trace elements, being known as nutrients in small amounts or toxic when they exceed small concentrations, we brought the One Health perspective to analyse how researchers approach this research theme. In this work, we propose a path through scientific production to promote innovation, sustainability of animal production, food safety and human health. Abstract The objective was to investigate the context, approach and research topics present in the papers that analysed trace elements in beef cattle to identify gaps and scientific perspectives for the sustainable management of trace elements in livestock. The main research groups came from the United States, Spain, Japan, Brazil, India and Slovakia, which represented 31% of the papers produced. Only 37% of studies addressed aspects that integrated animal, environmental and human health. The reviewed papers concerned 56 elements and 15 bovine tissues (Cu, Zn, Pb, liver, muscle and kidney highlighted). The main gaps were (1) lack of research in developing countries, (2) the need to understand the impact of different environmental issues and their relationship to the conditions in which animals are raised, and (3) the need to understand the role of many trace elements in animal nutrition and their relationship to environmental and human health. Finally, we highlight possible ways to expand knowledge and provide innovations for broad emerging issues, primarily through expanding collaborative research networks. In this context, we suggest the adoption of the One Health approach for planning further research on trace elements in livestock. Moreover, the One Health approach should also be considered for managers and politicians for a sustainable environmental care and food safety.
Language Management & Development in CPEC: A Case Study of Special Economic Zone of Punjab

The article aims to understand the language management taking place in the Special Economic Zone of Punjab (China-Pakistan Economic Corridor—CPEC). It incorporates data from both local and Chinese employees. The importance of multi-culture setting at workplace is addressed in this study by incorporating the impact of globalization. Respondents were selected by using random stratified sampling method. Primary data were gathered using multiple research tools; questionnaires, in-depth interviews, observations, and focus group discussions. Findings suggested that Urdu is still the most preferred language followed by English for official purposes or Punjabi for informal communication among lower management. Mandarin still needs to make its place in the Pakistani multi-culture context. Top management from both sides has adopted a positive stance and is willingly accepting a different culture. Chinese employees are even trying to learn Urdu. Use of translators and applications to reduce language barriers is increasing. Financial Times. We are making such an effort to understand the global market. As you know, we live in an information-oriented era when countries with valuable pieces of information or intelligence win. So-called industrial policy is not necessarily the cause of our competitive position in world markets. The economic “miracle” of Japan is attributable in part to our eagerness to gather and analyze available information on world markets. I recommend that American executives do the same if they want to remain intact in the highly competitive global market. (Tung, 1990, p.102 )
Promoting knowledge sharing in foreign subsidiaries through global talent management: the roles of local employees’ identification and climate strength

Abstract This study investigates how global talent management (GTM) contributes to host-country national (HCN) knowledge sharing. Drawing from the social exchange, social identity, and attribution theories, we developed a theoretical model to examine how GTM influences HCN knowledge sharing via increased organizational identification and the moderating role of GTM climate strength in foreign subsidiaries. The survey results from 744 HCNs working for 28 foreign subsidiaries in South Korea demonstrate that HCNs’ perceived GTM enhances their knowledge sharing by increasing organizational identification. A cross-level interaction analysis further suggests that GTM climate strength facilitates a positive relationship between GTM perceptions and HCN knowledge sharing, emphasizing the effect of consistency between the perceived GTM of employees and that of employers.
Cross-Linguistic Influences in Writing: A Case Study of a Chinese International Student

There has been a longstanding debate on the use of native language (L1) in second language acquisition (SLA). One important topic in language education to investigate is the use of language in the second language (L2) writing process. The majority of studies have focused on L2 writers in English as a foreign language (EFL) settings. Quantitative research approaches have been dominant. Nevertheless, the complexity of this issue cannot be comprehensively explored without qualitative analysis. This case study investigates the language use of a Chinese international college student in the United States throughout the L2 writing process. It adopts a qualitative research approach. The findings show that language learners draw upon their entire linguistic repertoire while writing; even those with a high proficiency level still rely upon their L1 in the L2 writing process. The findings also reveal the multiple functions of the L1 in facilitating L2 writing. Although this study primarily focuses on the linguistic influences of the L1, its implications can be generalized to a broader context. Teachers working with English learners (ELs) or bilingual students are highly recommended to acknowledge and gain a comprehensive understanding of the value of students’ linguistic knowledge, as well as embrace and strategically utilize students’ linguistic repertoires.
Pile-Supported Wharves Subjected to Inertial Loads and Lateral Ground Deformations. I: Experimental Results from Centrifuge Tests

15 Five dynamic, large-scale centrifuge tests on pile-supported wharves were used to 16 investigate the timeand depth-dependent nature of kinematic and inertial demands on the deep 17 foundations during earthquake loading. The wharf structures in the physical experiments were 18 subjected to a suite of recorded ground motions and imposed superstructure inertial demands on 19 the piles. Partial to full liquefaction in loose sand resulted in slope deformations of varying 20 magnitudes that imposed kinematic demands on the piles. It was found that the wharf inertia and 21 soil displacements were always in-phase during the critical cycle when bending moments were at 22 their maximum values. The test results were analyzed to provide the relative contributions of peak 23 inertial loads and peak soil displacements during critical cycles, and the data revealed the depth24 dependency of these factors. The results of this study are used in a companion paper to provide 25 recommendations for the design of pile-supported wharves subjected to foundation deformations. 26