Miracle-dz/UniFAR-FTUs huggingface dataset:
Dimension Reduction of Neural Models Across Multiple Spatio-temporal Scales

In general, reducing the dimensionality of a complex model is a natural first step to gaining insight into the system. In this dissertation, we reduce the dimensions of models at three different scales: first at the scale of microscopic single-neurons, second at the scale of macroscopic infinite neurons, and third at an in-between spatial scale of finite neural populations. Each model also exhibits a separation of timescales, making them amenable to the method of multiple timescales, which is the primary dimension-reduction tool of this dissertation. In the first case, the method of multiple timescales reduces the dynamics of two coupled n-dimensional neurons into one scalar differential equation representing the slow timescale phase-locking properties of the oscillators as a function of an exogenous slowly varying parameter. This result extends the classic theory of weakly coupled oscillators. In the second case, the method reduces the many spatio-temporal \yp{dynamics of} ``bump'' solutions of a neural field model into its scalar coordinates, which are much easier to analyze analytically. This result generalizes existing studies on neural field spatio-temporal dynamics to the case of a smooth firing rate function and general even kernel. In the third case, we reduce the dimension of the oscillators at the spiking level -- similar to the first case -- but with additional slowly varying synaptic variables. This result generalizes existing studies that use scalar oscillators and the Ott-Antonsen ansatz to reduce the dimensionality and determine the synchronization properties of large neural populations.
Parametric or nonparametric: The FIC approach

Should one rely on a parametric or nonparametric model when analysing a given data set? This classic question cannot be answered by traditional model selection criteria like AIC and BIC, since a nonparametric model has no likelihood. The purpose of the present paper is to develop a focused information criterion (FIC) for comparing general non-nested parametric models with a nonparametric alternative. It relies in part of the notion of a focus parameter, a population quantity of particular interest in the statistical analysis. The FIC compares and ranks candidate models based on estimated precision of the different model-based estimators for the focus parameter. It has earlier been developed for several classes of problems, but mainly involving parametric models. The new FIC, including also nonparametrics, is novel also in the mathematical context, being derived without the local neighbourhood asymptotics underlying previous versions of FIC. Certain average-weighted versions, called AFIC, allowing several focus parameters to be considered simultaneously, are also developed. We concentrate on the standard i.i. d. setting and certain direct extensions thereof, but also sketch further generalisations to other types of data. Theoretical and simulation based results demonstrate desirable properties and satisfactory performance.
The role of non‐coaxiality in the simulation of strain localization based on classical and Cosserat continua

It is normally accepted that materials inside the shear band undergo severe rotation of the principal stress direction, which causes non‐coaxiality between the principal stress and principal plastic strain rate. However, classical plasticity flow theory implicitly assumes that the principal stress and the principal plastic strain rate are coaxial; thus, it may not correctly predict the onset of the shear band. In addition, classical continuum does not contain any internal length scales; as a result, it cannot provide a reasonable shear band thickness. In this study, the original vertex non‐coaxial plastic model based on the classical continuum is extended to the Cosserat continuum. The corresponding codes are implemented via the interface of the user defined element subroutine in ABAQUS. Through a simple shear test, the effectiveness of the user's codes is verified. Through a uniaxial compression test, the influence of non‐coaxiality on the onset, the orientation, and the thickness of the shear band is investigated. Results show that the onset of the shear localization is delayed, and the thickness of the shear band is widened when the non‐coaxial degree increases, while the orientation of the shear band is little affected by the non‐coaxial degree. In addition, it is found that the non‐coaxiality can weaken the micro‐polar effect to some extent; nonetheless, the Cosserat non‐coaxial model still has its advantage over the classical non‐coaxial model in capturing the pre‐bifurcation as well as the post‐bifurcation behaviors of strain localization. Copyright © 2016 John Wiley & Sons, Ltd.
Event‐triggered adaptive tracking control for a class of uncertain stochastic nonlinear systems with Markov jumping parameters

This paper aims to investigate the problem of event‐triggered adaptive tracking control for a class of stochastic nonlinear systems with Markov jumping parameters. Since the stochastic system contains unknown parameters, the assumption of the stochastic input‐to‐state stability is a difficult task to check. To overcome the design difficulty, mode‐dependent adaptive controllers and the event‐triggered strategy are designed simultaneously with the help of backstepping technique. The stochastic input‐to‐state stability assumption is avoided by adding correction terms in controller to compensate the measurement errors. The proposed control schemes guarantee that all signals in the closed‐loop system remain bounded in probability and the tracking error signals eventually converge to the compact set in the sense of mean quartic value. Finally, simulation results show the effectiveness of the proposed approach.
Effect of asymmetric spin–orbit coupling on the electronic structure properties of noncentrosymmetric superconductor

We report a theoretical investigation of the electronic structure properties of weakly correlated electronic noncentrosymmetric superconductor ( K). The first-principle calculations have been performed using the full potential linearised-muffin-thin-orbital method and including both scalar relativistic and fully relativistic (FR) treatments. We detect distinct differences between the data obtained from the two applied approaches. In particular, the bands along the , and separate and Fermi surfaces become highly anisotropic in FR calculations. The observed differences are ascribed to a strong effect of the asymmetric spin–orbit coupling with a splitting energy of order of –100 meV. Furthermore, we unveil that the valence bands originating from the Fe-3d orbitals essentially compose peak-structured profile in density of states (DOS) with a sharp peak situated at 0.65 eV below . The latter feature reflects the presence of a Van Hove type singularity. The main contribution to DOS at the Fermi level , however, comes equally from the Th-6d and Fe-3d electronic orbitals. The calculated value = 16.7 eV/f.u results in theoretical Sommerfeld coefficient = 39.31 mJ/mol K and electron–phonon coupling parameter = 0.34. The theoretical electronic structure properties of are discussed in comparison with those of other noncentrosymmetric superconductors.
Instability of pressure-driven gas–liquid two-layer channel flows in two and three dimensions

We study unstable waves in gas–liquid two-layer channel flows driven by a pressure gradient, under stable stratification, not assumed to be set in motion impulsively. The basis of the study is direct numerical simulation (DNS) of the two-phase Navier–Stokes equations in two and three dimensions for moderately large Reynolds numbers, accompanied by a theoretical description of the dynamics in the linear regime (Orr–Sommerfeld–Squire equations). The results are compared and contrasted across a range of density ratios $r=\unicode[STIX]{x1D70C}_{liquid}/\unicode[STIX]{x1D70C}_{gas}$ . Linear theory indicates that the growth rate of small-amplitude interfacial disturbances generally decreases with increasing $r$ ; at the same time, the cutoff wavenumbers in both streamwise and spanwise directions increase, leading to an ever-increasing range of unstable wavenumbers, albeit with diminished growth rates. The analysis also demonstrates that the most dangerous mode is two-dimensional in all cases considered. The results of a comparison between the DNS and linear theory demonstrate a consistency between the two approaches: as such, the route to a three-dimensional flow pattern is direct in these cases, i.e. through the strong influence of the linear instability. We also characterize the nonlinear behaviour of the system, and we establish that the disturbance vorticity field in two-dimensional systems is consistent with a mechanism proposed previously by Hinch (J. Fluid Mech., vol. 144, 1984, p. 463) for weakly inertial flows. A flow-pattern map constructed from two-dimensional numerical simulations is used to describe the various flow regimes observed as a function of density ratio, Reynolds number and Weber number. Corresponding simulations in three dimensions confirm that the flow-pattern map can be used to infer the fate of the interface there also, and show strong three-dimensionality in cases that exhibit violent behaviour in two dimensions, or otherwise the development of behaviour that is nearly two-dimensional behaviour possibly with the formation of a capillary ridge. The three-dimensional vorticity field is also analysed, thereby demonstrating how streamwise vorticity arises from the growth of otherwise two-dimensional modes.
Dupilumab effectively and rapidly treats bullous pemphigoid by inhibiting the activities of multiple cell types

Background Bullous pemphigoid (BP) is an autoimmune skin-blistering disease. Systemic corticosteroids remain the first line treatment for moderate-to-severe BP with the potential for severe adverse events. Dupilumab has emerged as an alternative option for BP patients. Objective We evaluated the efficiency and safety of dupilumab on BP treatment and explored a mode of drug action in depth. Methods and results A multicenter retrospective cohort included 20 BP patients who received dupilumab with or without systemic corticosteroid in dupilumab group, and 20 matched BP patients who received corticosteroid alone in conventional group. Serum samples were collected from 20 patients (10 from dupilumab group and 10 from conventional group) at baseline and week 4. Compared to systemic corticosteroid alone, dupilumab with or without systemic corticosteroid was similarly efficacious in clinical remission at week4 (complete remission plus partial remission: 100%) and week24 (complete remission plus partial remission:100%), but allowing significant decreases in the cumulative doses of corticosteroids with reducing the incidence of adverse events. However, dupilumab did not decrease BP180 antibody despite an obvious clinical improvement. Comparative plasma proteomic analysis performed before and after treatment in 3 BP patients from dupilumab group revealed that drug use was associated with 30 differentially expressed proteins, including 26 down-regulated and 4 up-regulated proteins. The former consisted of immune related proteins involved in T/B cell interactions (inducible T-cell co-stimulator ligand, ICOSL) and in the activation of eosinophils (PRG2), mast cells (S100A12), and complement (CR2). TARC and ICOSL levels correlated with BP severity in patients who received either dupilumab or conventional treatment. Conclusion Dupilumab has similar efficacy in treating BP as conventional drugs, by inhibiting the activities of many types of immune cells and complement, and regulating the interactions between T and B cells.
Field-induced oblique helicoidal cholesteric phases in mixtures of chiral and achiral liquid crystalline molecules

ABSTRACT We present a mean field theory to describe phase transitions in mixtures of chiral and achiral liquid crystalline molecules in the presence of an external field. When a longitudinal external field is applied parallel to the pitch axis of a chiral nematic phase (N*), the director of the N* phase can lead to an oblique heliconical cholesteric () state with a twist–bend distortion, in which a bend elastic constant is smaller than a twist elastic constant . We predict that the exists between N* and nematic (N) phases and can be controlled by temperature and concentration. We find various phase transitions: the first-order (isotropic) and the second-order , transitions, on the temperature–concentration plane. We also predict the pitch and the phase diagrams, depending on temperature and concentration under the external field. Graphical Abstract
A Transient Three-Dimensional Model of Micro Heat Pipes Used As an Integral Part of Semiconductor Devices

An analytical model is presented in this paper to simulate the transient temperature changes on a semiconductor device integrated with an array of micro heat pipes in response to the switch-on of a heat source inside the device. Effect of the embedded micro heat pipes is taken into account by assuming that the silicon wafer has a higher thermal conductivity in the direction of the heat pipe array than that in other two directions. Analytical solutions are obtained for various combinations of the heat sources and sinks, and a good agreement is shown by comparing the present solutions with the numerical results in the published paper.
Self-assessment of well-being and individual attitudes towards inequality

The problem of social inequality is a relevant subject of research, since in many ways all kinds of protest movements arise in the society when its different segments and groups feel and experience social injustice. The individual’s disadvantaged position in the society at present and his/her willingness to change it against the inability to do it is an important indicator of social instability. However, people’s perception of social injustice and inequality is different. The purpose of the present study is to explore the causes of economic inequality in Russia, as viewed by the population, as well as the attitudes to fairness of economic inequality and subjective assessment of one’s own chances of material success. The paper identifies the factors that influence subjective assessment of a person’s own chances. In the opinion of the population, it is non-meritocratic forms that are predominant in the Russian society. It was found that dissatisfaction with inequality is lower among the people who are poor today but contemplate to become rich in the future than among those who apprehend of becoming poor both now and in the future. It is shown that the individual’s subjective rank in income distribution is more important for one’s subjective well-being than the relative wage level.
Analysis of risk factors and short-term prognostic factors of arrhythmia in patients infected with mild/moderate SARS-CoV-2 Omicron variant

Background Complications, including arrhythmia, following severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection continue to be of concern. Omicron is the mainstream SARS-CoV-2 mutant circulating in mainland China. At present, there are few epidemiological studies concerning the relationship between arrhythmia and Omicron variant infection in mainland China. Objectives To investigate the risk factors of arrhythmia in patients infected with the SARS-CoV-2 Omicron variant and the factors influencing prognosis. Methods Data from 192 Omicron infected patients with symptoms of arrhythmia (AH group) and 100 Omicron infected patients without arrhythmia (Control group) were collected. Patients in the AH group were divided into the good and poor prognosis groups, according to the follow-up results 4–6 weeks after infection. The general and clinical data between the AH and Control groups, and between the good and poor prognosis groups were compared. The variables with differences between the groups were included in the multivariate logistic regression analysis, and the quantitative variables were analyzed by receiver operating characteristic curve to obtain their cut-off values. Results Compared with the control group, the body mass index (BMI), proportion of patients with a history of arrhythmia, proportion of antibiotics taken, heart rate, moderate disease severity, white blood cell (WBC) count, and the aspartate aminotransferase, creatine kinase (CK), CK isoenzyme (CK-MB), myoglobin (Mb), high-sensitive troponin I (hs-cTnI), lymphocyte ratio and high sensitivity C-reactive protein (hs-CRP) levels in the AH group were significantly higher (p < 0.05). In addition, obesity (BMI ≥24 kg/m2), fast heart rate (≥100 times/min), moderate disease severity, and WBC, CK-MB and hs-cTnI levels were independent risk factors of arrhythmia for patients with Omicron infection (p < 0.05), and hs-CRP was a protective factor (p < 0.05). Compared with the good prognosis group, the age, proportion of patients with a history of arrhythmia, heart rate, proportion of moderate disease severity, and hs-CRP, CK, Mb and hs-cTnI levels were significantly higher in the poor prognosis group, while the proportion of vaccination was lower in the poor prognosis group (p < 0.05). Advanced age (≥65 years old), proportion of history of arrhythmia, moderate disease severity, vaccination, and hs-CRP, Mb and cTnI levels were independent factors for poor prognosis of patients with arrhythmia (p < 0.05). Conclusion The factors that affect arrhythmia and the prognosis of patients infected with Omicron include obesity, high heart rate, severity of the disease, age. history of arrhythmia, WBC, hs-CRP, and myocardial injury indexes, which could be used to evaluate and prevent arrhythmia complications in patients in the future.
Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings

The use of medicinal plants to treat inflammatory conditions and painful processes has attracted the attention of scientists and health professionals due to the evidence that natural products can promote significant therapeutic benefits associated with fewer adverse effects compared to conventional anti-inflammatory drugs. The genus Plectranthus is composed of various plants with pharmacological potential, which are used to treat various diseases in traditional communities worldwide. The present study systematically reviewed Plectranthus species with anti-inflammatory and analgesic potential. To this end, a systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The search was conducted on the following databases: PubMed, ScienceDirect, SciVerse Scopus, and Web of Science. Different combinations of search terms were used to ensure more excellent article coverage. After the selection, a total of 45 articles were included in this review. This study identified twelve Plectranthus species indicated for the treatment of different inflammatory conditions, such as wounds, fever, bronchitis, abscess, asthma, hepatitis, labyrinthitis, tonsillitis, and uterine inflammation. The indications for pain conditions included headache, sore throat, heartburn, menstrual cramp, colic, toothache, stomachache, migraine, chest pain, abdominal pain, local pain, labor pain, and recurring pain. Among the listed species, ten plants were found to be used according to traditional knowledge, although only four of them have been experimentally studied. When assessing the methodological quality of preclinical in vivo assays, most items presented a risk of bias. The SR results revealed the existence of different Plectranthus species used to treat inflammation and pain. The results of this systematic review indicate that Plectranthus species have the potential to be used in the treatment of diseases with an inflammatory component, as well as in the management of pain. However, given the risk of biases, the experimental analysis of these species through preclinical testing is crucial for their safe and effective use.
Characterization Variation of the Differential Coloring Substances in Rapeseed Petals with Different Colors Using UPLC-HESI-MS/MS

Rapeseed’s (Brassica napus L.) colorful petals have important ornamental values. However, the mechanisms of regulating petals coloration in rapeseed are still unknown. In our study, we investigated the key differential coloring substances in nine rapeseed cultivars with different petal colors, and 543 metabolites were detected and characterized through UPLC-HESI-MS/MS. Among them, the kinds and contents of flavonols, flavones, and anthocyanidins were the main contributors to petals’ coloration. Tamarixetin-, quercetin-, butin-, naringenin- and luteolin-derivates were the main pigment bases in white and yellow petals. Peonidin-3,5-O-diglucoside, peonidin-3-O-(6″-O-caffeoyl)glucoside, and quercetin-derivatives were the main coloring substances in pink petals. Acylated cyanidin derivatives might lead to a series of different purple petal colors. Glycosylated anthocyanins were responsible for the coloration of rapeseed red petals, and peonidin-3-O-glucoside and kaempferol-derivatives were mainly detected from the red petals. These results provide comprehensive insights into the difference in flavonoid metabolites in rapeseed petals with different colors and supply theoretical supports for the breeding of novel colorful rapeseed cultivars.
Velocity fluctuations generated by the flow through a random array of spheres: a model of bubble-induced agitation

This work reports an experimental investigation of the flow through a random array of fixed solid spheres. The volume fraction of the spheres is 2 %, and the Reynolds number $Re$ based on the sphere diameter and the average flow velocity is varied from 120 to 1040. Using time and spatial averaging, the fluctuations have been decomposed into two contributions of different natures: a spatial fluctuation that accounts for the strong inhomogeneity of the flow around each sphere, and a time fluctuation that comes from the instability of the flow at large enough Reynolds numbers. The evolutions of these two contributions with the Reynolds number are different, so that their relative importance varies. However, when each is normalized by using its own variance and the integral length scales of the fluctuations, their spectra and probability density functions (PDFs) are almost independent of $Re$ . The spatial fluctuation mostly comes from the velocity deficit in the wakes of the spheres, and is thus dominated by scales larger than one or two sphere diameters. It is found to be responsible for the asymmetry of the PDFs of the vertical fluctuations and of the major part of the anisotropy level between the vertical and the horizontal components of the fluctuations. The time fluctuation dominates at scales smaller than the integral length scale. It is isotropic and its PDFs, well described by an exponential distribution, are non-Gaussian. The spectra of the spatial and the time fluctuations both show an evolution as the power $-3$ of the wavenumber, but not exactly in the same subrange. All these properties are found in remarkable agreement with the results of both experimental investigations and large eddy simulations (LES) of a homogeneous bubble swarm. This confirms that the main mechanism responsible for the production of bubble-induced fluctuations is the interaction of the velocity disturbances caused by obstacles immersed in a flow and that the structure of this agitation is weakly dependent on the precise nature of the obstacles. The understanding and the modelling of the agitation generated by the motion of a dispersed phase, such as the bubble-induced agitation, therefore require one to distinguish between the roles of these two contributions.