Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute Changes on Left Atrial Function during Incremental Exercise in Patients with Heart Failure with Mildly Reduced Ejection Fraction: A Case-Control Study

Background: the aim of this study was to assess acute changes in left atrial (LA) function during incremental aerobic exercise in patients with heart failure with mildly reduced ejection fraction (HFmrEF) in comparison to healthy subjects (HS). Methods: twenty patients with established HFmrEF were compared with 10 HS, age-matched controls. All subjects performed a stepwise exercise test on a cycle ergometer. Echocardiography was performed at baseline, during submaximal effort, at peak of exercise, and after 5 min of recovery. Results: HS obtained a higher value of METs at peak exercise than HFmrEF (7.4 vs. 5.6; between group p = 0.002). Heart rate and systolic blood pressure presented a greater increase in the HS group than in HFmrEF (between groups p = 0.006 and 0.003, respectively). In the HFmrEF group, peak atrial longitudinal strain (PALS) and conduit strain were both increased at submaximal exercise (p < 0.05 for both versus baseline) and remained constant at peak exercise. Peak atrial contraction strain (PACS) did not show significant changes during the exercise. In the HS group, PALS and PACS increased significantly at submaximal level (p < 0.05 for both versus baseline), but PALS returned near baseline values at peak exercise; conduit strain decreased progressively during the exercise in HS. Stroke volume (SV) increased in both groups at submaximal exercise; at peak exercise, SV remained constant in the HFmrEF, while it decreased in controls (between groups p = 0.002). Conclusions: patients with HFmrEF show a proper increase in LA reservoir function during incremental aerobic exercise that contributes to maintain SV throughout the physical effort.
An End-To-End Neuromorphic Radio Classification System with an Efficient Sigma-Delta-Based Spike Encoding Scheme

—Rapid advance in 5G communication and the Internet of Things has prompted the development of cognitive radio sensing for spectrum monitoring and malicious attack detection. An end-to-end radio classification system is essential to realize efficient real-time monitoring at the edge. This work presents an end-to-end neuromorphic system enabled by an efficient spiking neural network (SNN) for radio classification. A novel hardware-efficient spiking encoding method is proposed leveraging the Sigma-Delta modulation mechanism in analog-to-digital converters. It requires no additional hardware components, simplifies the system design, and helps reduce conversion latency. Following a designed hardware-emulating conversion process, the classification performance is verified on two benchmark radio modulation datasets. A comparable accuracy to an artificial neural network (ANN) baseline with a difference of 0.30% is achieved on the dataset RADIOML 2018 with more realistic conditions. Further analysis reveals that the proposed method requires less power-intensive computational operations, leading to 22× lower computational energy consumption. Additionally, this method exhibits more than 99% accuracy on the dataset when the signal-to-noise ratio is above zero dB. The SNN-based classification module is realized on FPGA with a heterogeneous streaming architecture, achieving high throughput and low resource utilization. Therefore, this work demonstrates a promising solution for constructing an efficient high-performance end-to-end radio classification system.
The Acceleration Development of Disadvantaged Regions Policy in Post-Pandemic Covid-19

Based on Presidential Regulation Number 18 of 2020 concerning National Mid-Term Development Plan 2020-2024 junto Presidential Regulation Number 63 of 2020 concerning Stipulation of Disadvantaged Regions 2020-2024, stated that currently, 62 districts have the status as disadvantaged regions. Referring to data from the Central Statistics Agency, it is stated that post-pandemic Covid-19, the poverty rate in the Disadvantaged Regions jumped in 2020 to 26.43% while the National Mid-Term Development Plan 2020-2024 target was 23.4%-24% in 2024. To overcome these problems, it is necessary to have a systematic policy made by the government to achieve the target of the accelerated development of disadvantaged regions in 2020-2024. It is also stated in the National Mid-Term Development Plan 2020-2024 that by the end of 2024, the target of 25 districts may be lifted from their disadvantaged status. By using a normative legal research method as well as a statute and conceptual approach, the authors get the results of the research that until this article was written, factually the government's policy was then poured into Presidential Regulation Number 105/2021 concerning the National Strategy of the Acceleration Development of Disadvantaged Regions 2020-2024 which was the legal form that formed as the government policy to overcome the problems that exist in disadvantaged regions 2020-2024 including post-pandemic covid-19. Besides that, the government uses a collaboration strategy to encourage the implementation of the accelerated development of disadvantaged regions 2020-2024 including post-pandemic Covid-19.
Sleep Traits Causally Affect the Brain Cortical Structure: A Mendelian Randomization Study

Background: Brain imaging results in sleep deprived patients showed structural changes in the cerebral cortex; however, the reasons for this phenomenon need to be further explored. Methods: This MR study evaluated causal associations between morningness, ease of getting up, insomnia, long sleep, short sleep, and the cortex structure. Results: At the functional level, morningness increased the surface area (SA) of cuneus with global weighted (beta(b) (95% CI): 32.63 (10.35, 54.90), p = 0.004). Short sleep increased SA of the lateral occipital with global weighted (b (95% CI): 394.37(107.89, 680.85), p = 0.007. Short sleep reduced cortical thickness (TH) of paracentral with global weighted (OR (95% CI): −0.11 (−0.19, −0.03), p = 0.006). Short sleep reduced TH of parahippocampal with global weighted (b (95% CI): −0.25 (−0.42, −0.07), p = 0.006). No pleiotropy was detected. However, none of the Bonferroni-corrected p values of the causal relationship between cortical structure and the five types of sleep traits met the threshold. Conclusions: Our results potentially show evidence of a higher risk association between neuropsychiatric disorders and not only paracentral and parahippocampal brain areas atrophy, but also an increase in the middle temporal zone. Our findings shed light on the associations of cortical structure with the occurrence of five types of sleep traits.
DALL-E: CREATING IMAGES FROM TEXT

: It is very difficult better modelling assumptions performed on a fixed type of dataset which has typically been the emphasis of text to image generation. These assumptions may contain sophisticated architectures, auxiliary losses, or side information provided while training, for example, labelling objects or dividing masks. We provide a simple transformer-based approach that autoregressively shows the text and image tokens as a single data stream. Our strategy is competitive with older domain models, when assessed in a zero-shot manner with suitable data and size.
Enhancement-mode CdS nanobelts field effect transistors and phototransistors with HfO2 passivation

As typical direct bandgap II–VI semiconductors, quasi-one dimensional CdS nanowires, nanobelts, and nanorods have shown great potential in electronic and optoelectronic applications. However, most nano-scale CdS Field Effect Transistors (FETs) work in the depletion-mode (D-mode) due to the high unintentional n-type doping concentration, which results in high power consumption under off-state. In addition, the large dark current limits to the specific detectivity when they are fabricated into phototransistors. Here, we have synthesized single crystal CdS nanobelts (NBs) on a SiO2/Si substrate via chemical vapor deposition. The CdS NB FETs were fabricated with HfO2 as a passivation layer. It is found that the working mode of the FETs was transformed from the D-mode to the enhancement-mode with the threshold voltage changing from −22.6 to 0.7 V due to the decrease in the defect density. The HfO2 passivated CdS NB phototransistor shows a responsivity of 4.7 × 104 A/W and an ultrahigh detectivity of 9.07 × 1014 Jones at the source-drain voltage of 1 V under an illumination wavelength of 450 nm. Our work demonstrates an effective way to achieve enhancement-mode CdS FETs and high performance phototransistors.
Profiling Citizens in the Smart City: A Quantitative Study in Wallonia

Based on the assumption that citizens can participate in smart city development, this paper aims to capture the diversity of their profiles and their positioning towards smart city dynamics. The article starts with a literature review of some models of citizens to better understand how they could be portrayed in the smart city era. Considering that there is no “general citizen” and that usual typologies remain restrictive, we construct tailor-made personas, i.e., fictitious profiles based on real data. To this end, we present the results of a large-scale survey distributed to highly educated Walloon people in the framework of a general public exhibition. The profiling focuses on three aspects: (1) perception of smart city dimensions, (2) intended behavior regarding smart city solutions, and (3) favorite participatory methods. The collected answers were first analyzed with descriptive and nonparametric statistics, then classified with a k-means cluster analysis. The main results are five personas, which highlight the coexistence of different citizen groups that think and behave in a specific way. This process of profiling citizens’ priorities, behaviors, and participatory preferences can help professional designers and local governments to consider various citizens’ perspectives in the design of future smart solutions and participatory processes.
BACKSLIDING ON CHILDHOOD IMMUNIZATIONS DUE TO ONGOING COVID-19 PANDEMIC: A RETROSPECTIVE STUDY IN BANADIR REGION, SOMALIA

Background: SARS-CoV-2 has resulted in a global public health crisis. During the pandemic, considerable delay was observed making it impossible for some children to receive their due vaccines on time. Like most resource-poor countries, COVID-19 pandemic is thought to have a negative impact on Somalia’s immunization coverage. Materials and methods: This study aimed to assess the impact of the COVID-19 pandemic on routine childhood immunization coverage in Somalia. A retrospective comparative cross-sectional approach was employed to investigate the number of under-5-year children who got their immunization from the two major mother and child hospital, (Banadir and SOS hospitals) in Mogadishu, Somalia from October 2019 to December 2020. To do this, a total of 112, 060 data relating to the routine childhood immunization (measles, polio, whooping cough, hepatitis B, pneumonia, and tuberculosis) were collected from the monthly immunization report-data from the two hospitals. Results: The results showed that all the vaccines except birth vaccines have remarkably dropped with Penta-3 (27%), Penta-2 (11%), measles (10%) and Penta-1 (8%) respectively. However, the birth vaccines (BCG and Polio 0) were not affected as observed in this study. The reduction in children immunization rate in Somalia may be a combination of many other factors, we however recognize that the COVID-19 pandemic may have contributed significantly to this outcome . Conclusion: The government needed to take proactive measures to encourage parents to present their children for immunizations, including increasing community awareness concerning the importance of these routine childhood immunizations despite the ongoing COVID-19 pandemics.
The benefits of clustering in TNF receptor superfamily signaling

The tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. This review paper synthesizes key findings from recent studies, highlighting the importance of clustering in TNF receptor superfamily signaling. We discuss the underlying molecular mechanisms of signaling, the functional consequences of receptor clustering, and potential therapeutic implications of targeting surface structures of receptor complexes.
ASSOCIATION OF EFFECTS OF COVID-19 PANDEMIC WITH STRESS, ANXIETY AND DEPRESSION AMONG STUDENTS OF CLASS 9 th - 12 th IN THE SCHOOLS OF DISTRICT AMRITSAR

Background: Adolescence is a tumultuous period of life where provision of stable environment is of paramount importance for proper growth and development. Disruption of this stability due to COVID-19 and its related lockdowns may have had huge effect on the individuals going through this turbulent period of life. Materials and Methods: A cross sectional study was conducted among students of 9th -12th class of government and private schools of urban and rural areas of Amritsar. Sample size was calculated using formula N > 4pq/ d2. Data was collected during the period of one year. Pre tested, semi structured questionnaire and DASS -21 scale were used. Chi squared tests were applied and statistical analysis was conducted using Epi-Info. P value <0.05 was considered to be statistically significant. Result: The prevalence of Stress, Anxiety and Depression was found to be 53%, 58% and 54% respectively having significant associations with online teaching and loneliness due to COVID-19. Conclusion: Stress, anxiety and depression were associated with factors like consistency with online classes, availability of device for online classes, academic performance & insecurity due to lockdown and loneliness. There is need to set up a healthy routine, busy enough to keep the students engaged in academics as well as extra-curricular activities to reduce the risk of stress, anxiety and depression among adolescents.
Autografts and Allografts in the Treatment of Focal Articular Cartilage Lesions

 Full-thickness chondral defects of the knee caused by acute or repetitive trauma when other cartilage repair techniques (eg, microfracture, osteochondral autografting or autologous chondrocyte implantation) would be inadequate due to lesion size, location, or depth.  Large (area >1.5 cm) or cystic (volume >3.0 cm) osteochondral lesions of the talus when autografting would be inadequate due to lesion size, depth, or location.  Revision surgery after failed prior marrow stimulation for large (area >1.5 cm) or cystic (volume >3.0 cm) osteochondral lesions of the talus when autografting would be inadequate due to lesion size, depth or location.
Effectiveness of chemotherapy using bortezomib combined with homoharringtonine and cytarabine in refractory or relapsed acute myeloid leukemia: a phase II, multicenter, prospective clinical trial

Background Refractory/relapsed acute myeloid leukemia (R/R AML) has unsatisfactory outcomes even after allogeneic hematopoietic stem cell transplantation. Long-term survival is mainly influenced by complete remission (CR) rates after induction therapies. Objectives To investigate CR/CR with incomplete hematologic recovery (CRi) rates and adverse events with a new induction therapy (bortezomib, homoharringtonine, and cytarabine [BHA]) for patients with R/R AML. Methods We enrolled 21 patients with R/R AML (median age, 42 [range, 30–62] years), who received BHA for remission induction (bortezomib, 1.3 mg/m2/day on days 1 and 4; homoharringtonine, 4 mg/m2/day for 5 days, and cytarabine, 1.5 g/m2/day for 5 days). CR and adverse events were assessed. Results After one course of BHA, the CR/CRi and partial remission rates were 38.1% and 14.3%, respectively, with an overall response rate (ORR) of 52.4% in 21 patients. 9 of 21 patients harbored FLT3-ITD or FLT3-TKD mutations, and achieved either CR/CRi or ORR of 66.7% (P=0.03) by comparison with that in R/R AML without FLT3 mutation. After induction therapy, consolidation chemotherapy or allogeneic hematopoietic stem cell transplantation led to a one-year overall survival of 27.8% in all patients. One-year relapse-free survival was 50% in 8 patients who had achieved CR/CRi after one course of BHA. During induction, non-hematologic adverse events (grade 3/4) commonly were infection (90.5%), hypokalemia (14.4%), hypocalcemia (14.3%), and mucositis (9.5%). In patients achieving CR, the median time to neutrophil count >0.5×109/L and time to platelet count >20×109/L were 15 (13–17) days and 13 (13–18) days, respectively. Conclusion BHA chemotherapy regimen was safe and tolerable to serve as an induction therapy for R/R AML, particularly with FLT3 mutation. The higher CR/CRi rate will give a clue to determine a potentialeffectiveness of BHA for AML patients carrying FLT3 mutation in a further investigation. Clinical trial registration https://www.chictr. org.cn/, identifier ChiCTR2000029841.
ASSESSING THE INFLUENCE OF HARD AND SOFT INFRASTRUCTURE ON PERCEIVED DESTINATION COMPETITIVENESS: PERSPECTIVE FROM VISITORS IN SARAWAK

Tourism is one of the rapid growing economic sectors in the world. Destination competitiveness became an imperative aspect for every country as it determines the tourism revenue of the country. Infrastructure is one of the determinants of destination competitiveness. There are two kinds of infrastructure namely hard infrastructure and soft infrastructure. The current study investigated the impact of hard infrastructure (transportation, telecommunication, accommodation) and soft infrastructure (government tourism policy, health services, and safety and security) on perceived destination competitiveness from tourists’ points of view. The study was conducted based on quantitative research. A PLS-SEM analysis was performed by using WarpPLS. The result indicated that transportation, accommodation, and health services have a significant relationship with perceived destination competitiveness. This study is expected to benefit policymakers and industry players in terms of decision-making. Besides, this study will equip more literature and evidence for scholars to perform further studies in the field.
Globalizing cities : inequality and segregation in developing countries

"Towards the end of the 20th century city re-emerged as a unit of analysis and globalization as an important context for analyzing social transformation and dynamics shaping the society. A city is the site where micro and macro social processes and global and local contexts can be articulated and observed. Urbanologists and social scientists have so far focused on those cities, which have been greatly benefitted by globalization. A lot of literature has come about on the cities in the developed countries but cities in the developing countries have not been studied much. These cities are not global but globalizing cities . The present book anthologizes various aspects of segregation in globalizing cities of ten developing countries of Africa, Asia and Latin America, which have been differently affected by globalization. Social issues at stake may be common to the developing countries; yet, the global contexts may have different connotations and consequences in the local structures. The main objective of this anthology is to study the socio-spatial segregation and inequalities that have emerged in such globalizing cities under the impact of globalization forces and local social structures. "
Consumer–Brand Relationships: A Contrast of Nostalgic and Non‐Nostalgic Brands

This research examined how consumer–brand relationships change when one contrasts brands perceived as nostalgic with brands perceived as non-nostalgic. Paired comparisons of brands in six product categories revealed that brand attachment, self-brand connections, and storytelling, as well as, the propensity to offer the brand as a gift and collect brand-derived products, depend on the nostalgic status of the brand. On a sample of 606 consumers, the results showed that a brand’s nostalgic status has a positive effect on attachment, self-brand connections, and storytelling. These effects had not previously been considered in nostalgia research. Furthermore, the nostalgic status of a brand has positive effects in terms of intention to purchase the brand as a gift and collect brand-derived products. Moreover, ANOVA results illustrate that consumer relationships with nostalgic brands are systematically stronger than with non-nostalgic brands. Finally, results indicated that product category moderates all of the dimensions of brand relationships while gender does not. © 2014 Wiley Periodicals, Inc.
Expression of bioactive compounds in different pepper cultivars (Capsicum annuum L.) in response to different fertilizer treatments

This research aimed at evaluating four cultivars of Capsicum annuum L. with different nutrient sources to ascertain the nutrient source that would improve the soil characteristic and promote the accumulation of carotenoids and flavonoids in peppers. Four nutrient sources: poultry manure, pig manure, goat manure, and nitrogen: phosphorus: potassium (NPK) were used for the study. The experiment was conducted as a 4 × 5 Factorial in a Complete Randomized Design (CRD) at the Botanical Garden of the University of Nigeria, Nsukka. The soils characteristic features were analyzed by standard methods. The fruits biochemical content was quantified with the aid of a High-Performance Liquid Chromatography at the National Research Institute for Chemical Technology, Zaria, Nigeria. The α-carotene level (333.48±0.27 mg/L) was the highest in “Nsukka yellow pepper” fruits grown on soil mixed with goat manure while β-carotene (45.56±0.29 mg/L) was the highest when grown on soil mixed with poultry manure. “Tatase” cv. planted on soil mixed with poultry manure expressed the highest fruit capsanthin level while lutein was highly expressed when grown on soil mixed with goat manure. In conclusion, growing “Nsukka yellow pepper” with goat manure could increase the production of α-carotene, while poultry manure will increase the production of β-carotene.