Miracle-dz/UniFAR-FTUs huggingface dataset:
SLC 19 A 1 , SLC 46 A 1 and SLCO 1 B 1 Polymorphisms as Predictors of Methotrexate-Related Toxicity in Portuguese Rheumatoid Arthritis Patients

Methotrexate (MTX) is used for rheumatoid arthritis (RA) treatment showing a wide toxicity profile. This study aimed to evaluate the influence of single nucleotide polymorphisms (SNPs) in genes encoding for MTX transporters with the occurrence of MTX-related toxicity (overall and gastrointestinal). A total of 233 Portuguese RA patients were genotyped for 23 SNPs. Haplotype analyses were performed and a toxicogenetic risk index (TRI) was created for SNPs that revealed to be statistically significant. Regarding MTX overall toxicity, an increased risk was associated to SLC19A1 rs7499 G carriers (p = 0.017), SLC46A1 rs2239907 GG (p = 0.030) and, SLCO1B1 rs4149056 T carriers (p = 0.040) and TT (p = 0.019). TRI revealed that patients with Index 3 were 18-fold more likely to present an adverse drug reaction when compared to those with Index 1 (p = 0.001). For MTX gastrointestinal toxicity, results demonstrated an increased risk associated with SLC19A1 rs7499 G carriers (p = 0.012) and GG (p = 0.045), SLC19A1 rs1051266 G carriers (p = 0.034), SLC19A1 rs2838956 A carriers (p = 0.049) and, SLCO1B1 rs4149056 T carriers (p = 0.042) and TT (p = 0.025). Haplotype analyses showed association between GGAG haplotype for SLC19A1 rs7499, rs1051266, rs2838956 and rs3788200 with MTX gastrointestinal toxicity (p = 0.029). TRI revealed that patients with Index 4 were 9-fold more likely to present a gastrointestinal disorder when compared to those with Index 1 (p = 0.020). This study demonstrated that SLC19A1, SLC46A1 and SLCO1B1 genotypes may help to identify patients with increased risk of MTX-related overall toxicity and that SLC19A1 and SLCO1B1 genotypes, and SLC19A1 haplotypes may help to identify patients with increased risk of MTX-related gastrointestinal toxicity.
Daunorubicin -TiO 2 Nanocomposites As ‘smart9 pH-Responsive Drug Delivery System,

Abstract 3479 Daunorubicin (DNR) with a broad spectrum of anti-tumor activity is limited due to the serious side-effects in the clinical application. The aim of this study was to explore the novel pH-responsive drug delivery system (DDS) based on titanium dioxide (TiO 2 ) nanoparticles (Nps) for its potential roles to enable more intelligently controlled release, enhance chemotherapeutic efficiency, and reduce the side-effects of DNR. DNR was loaded onto the TiO 2 Nps by forming (six-membered chelate) complexes with transition metal Ti to contract DNR-TiO 2 nanocomposites as DDS. The encapsulation efficiency and loading efficiency of DNR loaded TiO 2 Nps were assessed and calculated as 65.46±6.82% and 20.63±3.55%, respectively.The DNR was released from the DDS much more rapidly at pH 5.0 and 6.0 than at pH 7.4. The release behavior is a desirable characteristic for tumor-targeted drug delivery. Most DNR will remain in the carrier for a considerable time period at normal physiological conditions (pH 7.4), indicating the potential for the prolonged DNR retention time in the blood circulation and thereby greatly reducing the side effects to the normal tissues. On the other hand, once the DNR loaded TiO 2 Nps are taken up by tumor cells via endocytotic process, a faster release may occur at lower local pH, i.e, inside the endosome and lysosome of cancer cells ((pH 4.5∼6.5), leading to the significant improvement in cancer treatment efficacy. The DNR- TiO 2 nanocomposites as DDS induced the remarkable improvement in the anti-tumor activity, which were demonstrated by the flow cytometry, MTT assay and nuclear DAPI staining. Furthermore, the possible signaling pathway was explored by Western blot. For instance, in human leukemia cells (K562 cells), our observations demonstrated that the DDS could obviously increase the intracellular concentration of DNR and enhance its potential anti-tumor efficiency through inducing apoptosis in a caspase-dependent manner, indicating that DNR-TiO 2 nanocomposites could act as an efficient DDS importing DNR into target cancer cells. These findings revealed that such ‘smart9 DNR delivery strategy represent a promising approach in hematologic malignancy therapy. Disclosures: No relevant conflicts of interest to declare.
Study of Different Doses of Gabapentin for Post-Operative Pain Relief after Laparoscopic Cholecystectomy

DOI: 10.21276/sjams.2018. 6.4. 11 Abstract: This is a prospective, randomized, double blind, placebo controlled study conducted at Yashoda Superspeciality Hospital, Secunderabad, Telangana, India over 160 patients who underwent elective lap cholecystectomy during the period of 1st September 2015 – 30th May2016. Hospital Ethical Committee approval was taken prior to start this study. Sample size was calculated basing on the pilot study and keeping dropouts in mind total sample was decided 40 in each group. Sample size of 40 patients each, randomly allocated into four groups, using computer generated random number list. They were given tab. gabapentin 2hrs before surgery with sips of water. Group 1(Placebo), Group 2(GP-100mg), Group3 (GP-200mg), Group 4 (GP300mg). Oral Gabapentin 300 mg may be the optimal preoperative dose to reduce the severity of postoperative pain and has an opioid sparing effect after laparoscopic cholecystectomy. At this dose it is well tolerated and may be used as part of multimodal analgesia to improve the quality of postoperative pain relief.
NaCl-induced senescence in leaves of rice (Oryza sativa L) cultivars differing in salinity resistance

The influence of NaCl on senescence-related parameters (protein and chlorophyll concentrations, membrane permeability and chlorophyll fluorescence) was investigated in young and old leaves of five rice cultivars differing in salt resistance. NaCl hastened the naturally-occurring senescence of rice leaves which normally appears during leaf ontogeny: it decreased chlorophyll and protein concentrations and increased membrane permeability and malondialdehyde synthesis. Such an acceleration of deteriorative processes affected all leaves in sail-sensitive cultivars while it was more marked in oldest than in youngest leaves of sail-resistant genotypes. NaCl-induced senescence also involved specific modifications, such as an increase in basal non-variable chlorophyll fluorescence (F-0) recorded in all cultivars or a transient increase in soluble protein concentration recorded in salt-resistant genotypes only. Alteration of membrane permeability appeared as one of the first symptoms of senescence in rice leaves and allowed discrimination among cultivars after only 7 d of stress. In contrast, F-v/F-m ratio (variable fluorescence/maximal fluorescence) was the same for all cultivars during the first 18 d of stress and thus could not be used for identifying salt-resistant rice exposed to normal light conditions. Relationships between parameters involved in leaf senescence are discussed in relation to salinity resistance of rice cultivars. (C) 1996 Annals of Botany Company.
Presence and Consequences of Coexisting Methane Gas With Hydrate Under Two Phase Water‐Hydrate Stability Conditions

Methane hydrate saturation estimates from remote geophysical data and borehole logs are needed to assess the role of hydrates in climate change, continental slope stability, and energy resource potential. Here we present laboratory hydrate formation/dissociation experiments in which we determined the methane hydrate content independently from pore pressure and temperature and from electrical resistivity. Using these laboratory experiments, we demonstrate that hydrate formation does not take up all the methane gas or water even if the system is under two phase water‐hydrate stability conditions and gas is well distributed in the sample. The experiment started with methane gas and water saturations of 16.5% and 83.5%, respectively; during the experiment, hydrate saturation proceeded up to 26% along with 12% gas and 62% water remaining in the system. The coexistence of hydrate and gas is one possible explanation for discrepancies between estimates of hydrate saturation from electrical and acoustic methods. We suggest that an important mechanism for this coexistence is the formation of a hydrate film enveloping methane gas bubbles, trapping the remaining gas inside.
Comparison of Forecasting India’s Energy Demand Using an MGM, ARIMA Model, MGM-ARIMA Model, and BP Neural Network Model

Better prediction of energy demand is of vital importance for developing countries to develop effective energy strategies to improve energy security, partly because those countries’ energy demands are increasing rapidly. In this work, metabolic grey model (MGM), autoregressive integrated moving average (ARIMA), MGM-ARIMA, and back propagation neural network (BP) are adopted to forecast energy demand in India, the third largest energy consumer in the world after China and the USA. The average relative errors between the actual and simulated value are 1.31% (MGM), 1.07%, 0.92% (MGM-ARIMA), and 0.39% (BP). The high prediction accuracy indicates that the prediction result is effective. The result shows that India’s energy consumption will increase by 4.75% a year in the next 14 years. Compared with the 5.1% per year on average in 1995–2016, India’s energy consumption will still continue its steady growth at about 5% growth from 2017 to 2030.
LEI DE NEWCOMB BENFORD E AUDITORIA CONTÁBIL: UMA REVISÃO SISTEMÁTICA DE LITERATURA

Lei de Newcomb Benford - LNB, foi concebida pelo astronomo e matematico Simon Newcomb, em 1881. Seus estudos demonstraram que a ocorrencia de um numero natural, de modo espontâneo ou aleatorio, nao se dava na proporcao esperada de 1/9, mas segundo uma distribuicao logaritmica. Desde entao, esta lei vem sendo testada em muitas areas do conhecimento. Em financas corporativas, os estudiosos tem testado a lei para investigar fraudes em dados contabeis. Contudo, ainda nao ha consenso sobre a eficacia da LNB nesse âmbito. Assim, o objetivo deste artigo e identificar os argumentos favoraveis e contrarios, bem como os metodos de pesquisa e os principais achados das pesquisas sobre a aplicacao da LNB como ferramenta de auditoria. Para tanto, aplicou-se uma Revisao Sistematica de Literatura, seguindo os passos de Levy e Ellis (2006). Deste modo, alem de informacoes sobre autoria, modelos utilizados pelos autores para suportar suas conclusoes e seus principais achados, apresentam-se lacunas de pesquisa, e as implicacoes para o futuro da pesquisa sao discutidas. Palavras-chave: Lei de Newcomb Benford. Revisao sistematica. Auditoria contabil. ABSTRACT Newcomb Benford’s Law - LNB, was conceived by the astronomer and mathematician Simon Newcomb, in 1881. His studies showed that the occurrence of a natural number, spontaneously or randomly, did not occur in the expected proportion of 1/9, but according to a logarithmic distribution. Since then, this law has been tested in many areas of knowledge. In corporate finance, scholars have tested the law to investigate fraud in accounting data. However, there is still no consensus on the effectiveness of LNB in this area. Thus, the objective of this article is to identify the arguments for and against, as well as the research methods and the main findings of research on the application of LNB as an audit tool. For that, a Systematic Literature Review was applied, following the steps of Levy and Ellis (2006). Thus, in addition to information on authorship, models used by the authors to support their conclusions and main findings, research gaps are presented, and the implications for the future of research are discussed. Keywords: Newcomb Benford’s law. Systematic review. Accounting audit.
Conversational Gaze modelling in First Encounter Robot Dialogues

Given the popularity of humanoid social robots which can talk with humans and maintain human-like communication patterns, an interesting question is whether the users engage themselves with such systems in a manner similar to human-human communication. If the humanoid robot is perceived as a communicative agent, it can be hypothesized that the user’s engagement with the robot resembles social interaction rather than tool manipulation. This paper reports on a pilot study that explores if the hypothesis is supported in the context of a humanoid robot application which reads a digital newspaper interactively for the user. Human eye-gaze patterns are used as an objective measure of the engagement with the robot. The study found support for the hypothesis, but concludes that the interaction is socially less binding than with humans.
Characterisation and In Vivo Safety of Canine Adipose-Derived Stem Cells

Abstract The study characterises canine adipose-derived stem cells (cASCs) in comparison to human ASCs (hASCs) and tests their safety in a canine model after intravenous administration. cASCs from two dogs were cultured under hypoxic conditions in a medium supplemented with autologous serum. They were plastic adherent, spindle-shaped cells that expressed CD73, CD90, and CD44 but lacked CD45, CD14, HLA-DR, and CD34. cASCs differentiated toward adipogenic, osteogenic, and chondrogenic lineages, although adipogenic differentiation capacity was low. Blast transformation reaction demonstrated that these cells significantly suppress T-cell proliferation, and this ability is dose-dependent. Intravenous administration of a cell freezing medium, therapeutic dose of cASCs (2 × 106 live cells/kg), and five times higher dose of cASCs showed no significant side effects in two dogs. Microscopic tissue lesions were limited to only mild, non-specific changes. There were no signs of malignancy. The results of the study indicate that cASCs are similar to hASCs and are safe for therapeutic applications in a canine model. The proposed methodology for ASC preparation on a non-routine basis, which includes individually optimised cell culture conditions and offers risk-adapted treatment, could be used for future personalised off-the-shelf therapies, for example, in myocardial infarction or stroke.
Multi-Poverty in Cameroon: A Dimensional Scores-Approach

The primary objective of this study is to capture multi-poverty with values for welfare dimensions rather than the typical approach of a composite welfare indicator. The method used is multiple indicators multiple causes (MIMIC) modelling, which can be used to explain, measure and calculate the scores for five dimensions of welfare. Poverty analysis methods applied on these scores show that each type of poverty has specific determinants, although some determinants are common to several dimensions of poverty. Similarly, each region is affected by particular types of poverty while no form of poverty is unique to a single region. We thus propose to target multi-poverty via dimensional scores to formulate policy. A comparison with previous approaches shows that dimensional scores are more appropriate for identifying the specific needs of the population in the fight against poverty.
Cooperative Membership and Smallholder Farmers ’ Yields and Profits

Cooperatives are regarded as an institutional vehicle to help farmers mitigate market imperfections and improve smallholder welfare. Though much research has been done on what effect cooperatives have on farmers’ welfare, the question of how cooperatives affect farmers’ welfare remains largely unanswered. By using the case of apple farmers in China, we seek to answer this question by examining the effect of cooperative membership on yield and profit. The empirical analysis is based on field survey data collected among 551 apple farm households in Shaanxi and Shandong. An endogenous treatment regression model is employed to assess the average treatment effects of cooperative membership on the yield and profits per unit area. Our research shows that cooperative membership has a significantly positive effect on yields, but no significant effect on profits per unit area. Two pathways explain the different effects. First, cooperative services change members’ production practices, especially the use of inputs that lead to higher land productivity. Second, members on average spend more on fertilizers and use more hired labor than non-members, which results in higher production costs. The extra revenues generated by the increased yields roughly compensates the extra production costs of the members.
Petrology and geochemistry of olivine-phyric shergottites LAR 12095 and LAR 12240: Implications for their petrogenetic history on Mars

Larkman Nunatak (LAR) 12095 and LAR 12240 are recent olivine‐phyric shergottite finds. We report the results of petrographic and chemical analyses of these two samples to understand their petrogenesis on Mars. Based on our analyses, we suggest that these samples are likely paired and are most similar to other depleted olivine‐phyric shergottites, particularly Dar al Gani (DaG) 476 and Sayh al Uhaymir (SaU) 005 (and samples paired with those). The olivine megacryst cores in LAR 12095 and LAR 12240 are not in equilibrium with the groundmass olivines. We infer that these megacrysts are phenocrysts and their major element compositions have been homogenized by diffusion (the cores of the olivine megacrysts have Mg# ~70, whereas megacryst rims and groundmass olivines typically have Mg# ~58–60). The rare earth element (REE) microdistributions in the various phases (olivine, low‐ and high‐Ca pyroxene, maskelynite, and merrillite) in both samples are similar and support the likelihood that these two shergottites are indeed paired. The calculated parent melt (i.e., in equilibrium with the low‐Ca pyroxene, which is one of the earliest formed REE‐bearing minerals) has an REE pattern parallel to that of melt in equilibrium with merrillite (i.e., one of the last‐formed minerals). This suggests that the LAR 12095/12240 paired shergottites represent the product of closed‐system fractional crystallization following magma emplacement and crystal accumulation. Utilizing the europium oxybarometer, we estimate that the magmatic oxygen fugacity early in the crystallization sequence was ~IW. Finally, petrographic evidence indicates that LAR 12095/12240 experienced extensive shock prior to being ejected from Mars.
Microsatellite DNA reveals population genetic differentiation among sprat (Sprattus sprattus) sampled throughout the Northeast Atlantic, including Norwegian fjords

Sprat (Sprattus sprattus), small pelagic shoaling fish, were sampled from the Celtic, North, and Baltic seas, and 10 Norwegian fjords. Significant overall genetic differentiation was observed among samples when analysed with eight microsatellite DNA loci (Global FST ¼ 0.0065, p , 0.0001). The greatest genetic differences were observed between the Baltic and all other samples (largest pairwise FST ¼ 0.043, p , 0.0001). No significant genetic differentiation was observed between a sample from the Celtic Sea (CEL) and the North Sea (NSEA; FST ¼ 0.001, p ¼ 0.16), but variable levels of genetic differentiation were observed among samples collected from Norwegian fjords (pairwise FST ranging from 0 to 0.0096, most non-significant). All fjord samples were significantly differentiated to NSEA and CEL samples. Further, all fjord samples displayed reduced allelic richness compared with NSEA and CEL samples. Clearly, sprat display population genetic differentiation throughout the Northeast Atlantic, and there may be limited connectivity between Norwegian fjord and sea-going populations.
The local governance of culture-led regeneration projects: a comparison between Montreal and Toronto

This article analyses culture-led regeneration processes in the context of two case studies. We analyse the roles of urban stakeholders and the adaptation of regeneration strategies in two different local planning cultures: Toronto and Montreal. The two regeneration projects analysed are the redevelopment of the Toronto Entertainment District and a real-estate project proposal within the ‘Quartier des Spectacles’ in Montreal. The analysis highlights the specific planning culture embedded in local governance, aligned with two distinct applications of the creative city concept.
Alcohol andmale reproductive health : a cross-sectional study of 8344 healthy men from Europe and the USA

Tina Kold Jensen1,2,*, Shanna Swan3, Niels Jørgensen4, Jorma Toppari5, Bruce Redmon6, Margus Punab7, Erma Z. Drobnis8, Trine Berit Haugen9, Birute Zilaitiene10, Amy E. Sparks11, D. Stewart Irvine12,13, Christina Wang14, Pierre Jouannet15, Charlene Brazil16, Uwe Paasch17, AndreaSalzbrunn18,NielsErikSkakkebæk19,andAnna-MariaAndersson4 Department of Environmental Epidemiology, University of Southern Denmark, Winsløwsparken 17, Odense, Denmark Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark Physiology, University of Turku, Turku, Finland Departments of Medicine and Urologic Surgery, University Of Minnesota, Minneapolis, MN, USA Andrology Unit, Tartu University Clinicum, Tartu, Estonia Department of Obstetrics, Gynecology and Women’s Health, School of Medicine, University of Missouri, Columbia, MO, USA Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Obstetrics & Gynecology, University of Iowa, Iowa City, IA, USA Medical Directorate, NHS Education for Scotland, Edinburgh, UK Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK Clinical and Translational Research Center, Harbor-UCLA Medical Center, Torrance, CA, USA Biologie de la Reproduction, Hopital Cochin – Universite Paris V, Paris, France Department of Obstetrics and Gynecology, University of California, Davis, CA, USA Department of Dermatology/Andrology Unit, University of Leipzig, Leipzig, Germany Department of Andrology, Universitatsklinikum Hamburg-Eppendorf, Hamburg, Germany Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
JMJD 6 Licenses ER α-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM 1 / MED 12 Coactivator Complex

Wei-wei Gao1,4, Rong-quan Xiao1,4, Wen-juan Zhang1,4, Yi-ren Hu3,4, Bing-ling Peng1, Wenjuan Li1, Yao-hui He1, Hai-feng Shen1, Jian-cheng Ding1, Qi-xuan Huang1, Tian-yi Ye1, Ying Li1, Zhi-ying Liu1, Rong Ding1, Michael G. Rosenfeld3, and Wen Liu1,2,5,* 1School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiang’an South Road, Xiamen, Fujian 361102, China