Miracle-dz/UniFAR-FTUs huggingface dataset:
Insights of inhibition mechanism of sifuvirtide and MT-sifuvirtide against wild and mutant HIV-1 envelope glycoprotein41: a molecular dynamics simulation and binding free energy study

ABSTRACT Sifuvirtide (SFT) is the second generation inhibitor of HIV-1 gp41 fusion protein, which is under phase III clinical trial for anti-HIV. However, over a period of time virus develops resistance against SFT. To overcome resistance, methionine and threonine (MT) amino acids were implemented in the pocket binding domain of SFT namely MT-Sifuvirtide (MTSFT), which have more helicity; higher melting temperature and stability against resistance-virus. To date, the binding stability and functional role of MT-hook against wild type and mutant form of HIV-1 gp41 fusion protein are not known. In the present study, SFT and MTSFT were individually docked with the wild and V10A/A19I/Q24R mutant form of HIV-1 gp41. Further MD simulation was carried out to understand the stability of the ligand–protein complexes. The free energy values were calculated from the MD trajectories to understand the effect of mutation involved in the binding process. MD results revealed helix to loop type conformational changes in N-heptad repeat (NHR) of gp41 due to mutation. Intermolecular interactions reveal that MTSFT forms more strong interactions with NHR of gp41 than SFT, which is critical for six-helix bundle stabilisation. Hence, the results explained the detailed functional role of MT-hook against gp41 fusion at the molecular level.
Pengaruh Komitmen Profesional Dan Sosialisasi Antisipatif Mahasiswa Akuntansi Terhadap Niat Whistleblowing Dengan Religiusitas Sebagai Variabel Moderasi

The accounting profession has emphasized the need for professionals to develop attitudes early in their careers, even before they moved professions. This study discusses the professional commitment and anticipatory socialization of accounting students towards whistleblowing intentions. Religiosity as a moderating variable that moderates the relationship between professional commitment and anticipatory socialization of accounting students to whistleblowing intentions. The population in this study is accounting students in the city of Padang. The sample is based on the purposive stratified sampling method. The data used in this study are primary data. This study used a questionnaire instrument from 277 respondents. The method of analysis is done by using MRA (Moderated Regression Analysis). The results showed that professional commitment had a significant effect on whistleblowing, but anticipatory socialization had a significant negative effect on whistleblowing. Religiosity weakens the relationship between professional commitment to whistleblowing but supports the relationship between anticipatory socialization of whistleblowing.
Gender Differences in Response to Therapy for Cardiovascular Diseases

DOI: 10.2174/1875692115666170508153322 Abstract: In the last decades, aging of population is becoming even more prevalent, with consequent increasing requirement in health assistance and services. Physical and social environments can affect health directly, or through barriers or incentives conditioning opportunities, decisions and behavior. Moreover, the relationship with environment varies according to several personal characteristics including family background, sex and ethnicity. The impact of these factors is often skewed by these characteristics, leading to inequalities in health. In almost all countries, the older population is predominantly female. The prevalence and incidence of Cardiovascular Diseases (CVD) are reported to be lower in women than in men, increasing with age in both genders, but at advanced ages women outnumber men. Gender-differences in the contribution of various pathophysiological processes, combined with suboptimal recognition of female specificities, may explain sexdifferences in presentation and outcomes of CVD and also partially explain the differences in cardiovascular drug therapy related to gender, where other behavioral and cultural factors can be involved. Starting by the conflicting data in literature, the aim of this article is to summarize the gender differences available on the use of the main cardiovascular drugs, and the possible explanation for these disparities. Till date, data on gender differences in cardiovascular therapy are still controversial, and overall no established factors have been identified to discriminate the different approach in the choice of cardiovascular drugs by gender. Then further more structured and bigger trials should be performed to target these issues, and to better clarify the underlining involved mechanisms.
A lipid-invasion model for Alzheimer’s Disease

This paper describes a potential new explanation for Alzheimer’s disease (AD), referred to here as the lipid-invasion model. It proposes that AD is primarily caused by the influx of lipids following the breakdown of the blood brain barrier (BBB). The model argues that a principal role of the BBB is to protect the brain from external lipid access. When the BBB is damaged, it allows a mass influx of (mainly albumin-bound) free fatty acids (FFAs) and lipid-rich lipoproteins to the brain, which in turn causes neurodegeneration, amyloidosis, tau tangles and other AD characteristics. The model also argues that, whilst β-amyloid causes neurodegeneration, as is widely argued, its principal role in the disease lies in damaging the BBB. It is the external lipids, entering as a consequence, that are the primary drivers of neurodegeneration in AD. , especially FFAs, which induce oxidative stress, stimulate microglia-driven neuroinflammation, and inhibit neurogenesis. Simultaneously, the larger, more lipid-laden lipoproteins, characteristic of the external plasma but not the CNS, cause endosomal-lysosomal abnormalities, amyloidosis and the formation of tau tangles, all characteristic of AD. In most cases (certainly in late-onset, noninherited forms of the disease) amyloidosis and tau tangle formation are consequences of this external lipid invasion, and in many ways more symptomatic of the disease than causative. In support of this, it is argued that the pattern of damage caused by the influx of FFAs into the brain is likely to resemble the neurodegeneration seen in alcohol-related brain damage (ARBD), PeerJ Preprints | https://doi.org/10.7287/peerj.preprints. 27811v5 | CC BY 4.0 Open Access | rec: 18 Nov 2019, publ: 18 Nov 2019 A lipid-invasion model for Alzheimer's Disease a disease that shows many similarities to AD, including the areas of the brain it affects. The fact that neurodegeneration is far more pronounced in AD than in ARBD, and characterised by other features, such as amyloidosis and tau tangles, most likely results from the greater heterogeneity of the lipid assault in AD compared with ethanol alone. The lipid-invasion model, described here, arguably provides the first cohesive, multi-factorial explanation of AD that accounts for all currently known major risk factors, and explains all ADassociated pathologies, including those, such as endosomal-lysosomal dysfunction and excessive lipid droplet formation, that are not well-accounted for in other explanation of this disease.
Correlation between glycosylated hemoglobin level and lipid profile in patients with Diabetes mellitus

The present study was conducted in the Department of Biochemistry, M.N. R. Medical College, Sangareddy District, Telangana, State, India. A total of n=75 subjects were selected, comprising n=50 subjects (n=25 male and n=25 female) with known Diabetes mellitus and n=25 non-diabetic healthy controls. The study was aimed to investigate the pattern of dyslipidemia among the subjects and understand its association with glycosylated hemoglobin (HbA1c) level in diabetic and healthy controls. Biochemical parameters were estimated by following standard methods. The mean and SD values of fasting blood glucose (164.56 ± 10.41) and post prandial blood glucose (228.60 ± 12.66) were significantly (p<0.05) increased in diabetic cases compared to non-diabetic controls (84.44 ± 5.04 and 123.64 ± 6.20 respectively). The mean and SD of HbA1c (8.88 ± 0.49) in diabetic cases were significantly higher compared to controls (5.08 ± 0.45). Poor glycemic control indicated by HbA1c level >8 was seen in n=34 (68%) of diabetic patients. Poor glycemic control was associated with dyslipidemia in n=24 (48%) diabetic patients. Whereas, 6 cases (12%) showed worse glycemic control with HbA1c level > 9%, and 8 cases sh owed good glycemic control with HbA1C level ≤ 6%. The mean±SD of serum total cholesterol (216.48 ± 10.87), triglycerides (214.84 ± 8.98), LDL-cholesterol (149.52 ± 5.06) were significantly (p<0.05) high in diabetic cases over controls (167.68 ± 6.83, 154.84 ± 5.38 and 92.12 ± 5.36 respectively). HDL-cholesterol (31.83 ± 4.42) was significantly reduced in diabetic patients compared to controls (46.94 ± 6.84). The lipid profile values in female diabetic and non-diabetic subjects were slightly increased compared to male subjects. However, the values were not statistically significant. This study showed a significant correlation between levels of glycosylated hemoglobin (HbA1c) and lipid profile. This may help in predicting the lipid profile levels from the degree of glycemic control and therefore, identifying the patients with increased risk of diabetic complications.
Evaluation of storage temperature, packaging system and storage duration on postharvest quality of straw mushroom (Volvariella volvacea)

Volvariella volvacea is an edible mushroom, highly perishable and has a very short shelf life (1-2 days) at room temperature (RT). This research was conducted to determine the postharvest qualities at different storage temperatures (10, 15oC, and RT) and storage durations (0, 2, 4, 6 and 8 days) in perforated polyethylene (PE) films. V. volvacea stored at 15°C showed lower weight loss, no veil opening and retained higher firmness. Thus, the mushrooms were expanded to examine the optimum packaging systems (perforation, PVC film wrap, vacuum and control) applied to V. volvacea for 0-8 d at 15oC. PVC film was shown to maintain higher firmness, lower weight loss, browning degree, and PPO enzyme activity compared to other packaging. Minor damages and ultrastructure tissue shrivelling were seen in PVC film packaging. Overall, V. volvacea was best stored at 15°C in PVC film to retain their quality and extend its shelf life.
Abdominal pain and eosinophilia in suburban goat keepers — trichostrongylosis

The Medical Journal of Australia ISSN: 0025729X 1 May 2006 184 9 467-469 ©The Medical Journal of Australia 2006 www.mja. com.au Lessons from Practice in Australia: 60 cases were reported from Queen Hookworm Campaign between 1923 and 1928, and five cases were detected out of 46 000 stool exam Queensland laboratory between 1992 and 1995. H lence data are difficult to acquire because miscla common, and symptoms may be mild or non-ex ric ub Hu T hostrongylus species are zoonotic nematode parasites, iquitous among herbivorous mammals worldwide. man infection is most common in herders of sheep and goats, but may potentially be acquired from contact with faeces of other infected host animals such as cattle, camels and donkeys. Isolated cases or small series in humans have long been recognised sland by the more recently, inations at a uman prevassification is istent. Trichostrongylus eggs are most commonly mistaken for hookworm eggs, which have a similar shape, although the former are larger (73– 94 40–53 μm), and slightly pointed at one or both ends (Box 3). Misidentification occurred twice in Patient 1; eggs were initially identified as those of hookworm, and adult worms seen on endoscopic biopsy as Enterobius vermicularis. Diagnostic difficulties also arise because of the long prepatent period. Even after the period of maturation from larval stage to egg-laying adults, passage of eggs may still be scanty or undetectable for some time (with reported delays of 4 months to 2 years between symptom onset and detection of eggs). This probably explains the absence of detectable eggs in the stool specimens of Patient 2. Clinical records
Study of dosimetric characteristics of a commercial optically stimulated luminescence system

Abstract Background Optically stimulated luminescence dosimeters (OSLDs) have a number of advantages in radiation dosimetry making them an excellent dosimeter for in vivo dosimetry. The study aimed to study the dosimetric characteristics of a commercial optically stimulated luminescence (OSL) system by Landauer Inc., before using it for routine clinical practice for in vivo dosimetry in radiotherapy. Further, this study also aimed to investigate the cause of variability found in the literature in a few dosimetric parameters of carbon-doped aluminium oxide (Al2O3:C). Materials and methods The commercial OSLD system uses Al2O3:C nanoDotTM as an active radiation detector and InLightTM microStar® as a readout assembly. Inter-detector response, energy, dose rate, field size and depth dependency of the detector response were evaluated for all available clinical range of photon beam energies in radiotherapy. Results Inter-detector variation in OSLD response was found within 3·44%. After single light exposure for the OSL readout, detector reading decreased by 0·29% per reading. The dose linearity was investigated between dose range 50–400 cGy. The dose response curve was found to be linear until 250 cGy, after this dose, the dose response curve was found to be supra-linear in nature. OSLD response was found to be energy independent for Co60 to 10 MV photon energies. Conclusions The cause of variability found in the literature for some dosimetric characteristics of Al2O3:C is due to the difference in general geometry, construction of dosimeter, geometric condition of irradiation, phantom material and geometry, beam energy. In addition, the irradiation history of detector used and difference in readout methodologies had varying degree of uncertainties in measurements. However, the large surface area of the detector placed in the phantom with sufficient build-up and backscatter irradiated perpendicularly to incident radiation in Co60 beam is a good method of choice for the calibration of a dosimeter. Understanding the OSLD response with all dosimetric parameters may help us in estimation of accurate dose delivered to patient during radiotherapy treatment.
Chebyshev series solution for a class system of linear integro-differential equations with weakly singular kernel

Bu calismada, zayif tekil cekirdekli lineer integro diferansiyel denklemlerin bir sinifi icin bir numerik algoritma sunulacaktir. Bu algoritma birinci tip Chebyshev polinom bazi yardimiyla polinom yaklasimi ve siralama metodunu temel almaktadir. Bu metot verilen denklem ve kosullari bir matris denklemine donusturur. Numerik metodun uygulanabilirligini ve dogrulugunu gostermek amaciyla bazi ornekler incelenecektir. Sunulan metot diger metotlar ile kiyaslanmistir.
Multi-product Dynamic Pricing (and Ranking) with Limited Inventories under Cascade Click Model

We consider a multi-product dynamic pricing problem with limited inventories under the so-called Cascade Click model, which is one of the most popular click models used in practice for analyzing customers' click-and-search behavior in large-scale web analytic applications. We present three fundamental results. First, despite the highly non-linear structure of the problem, we derive a sufficiently general characterization of the optimal pricing policy and show that it has a different structure than the optimal policy under the standard pricing model. Second, we show that the optimal expected total revenues under the Cascade Click model can be upper-bounded by the objective value of an approximate deterministic pricing problem, and that this deterministic problem can be efficiently solved. This result is reminiscent of the classic upper-bound result in the standard Revenue Management (RM) setting, whose importance and impact on RM research in the past two decades cannot be overstated. Third, we show that two heuristic policies that are known to have strong performance guarantees in the standard RM setting can be properly adapted to the setting with Cascade Click model and retain their strong performance guarantees.
Learning Stochastic Weight Masking to Resist Adversarial Attacks

xv List of Abbreviations Used . xvi Acknowledgements . xviii Chapter
Factors Affecting the Adoption of Financial Information Systems Based on UTAUT Model

The main aim of this paper is to study the factors that could effect the adoption of financial information systems by small and medium-sized enterprises in Jordan based on the unified theory of acceptance and use of technology (UTAUT). This study is quantitative; a questionnaire was used to collect the data. The sample size for the study is 322 small and medium-sized enterprises in Jordan. The findings of the study indicated that performance expectancy, effort expectancy, social influence and facilitating conditions effect significantly on the adoption of financial information system by small and medium-sized enterprises.
A Manual of Acupuncture

2. Direct Deposit: China Books Sydney, NAB World Square, BSB #082-024 Account #55251-0842. Signature: Name New edition incorporates thumb indentations for the 14 main channels plus extra points and a dust jacket. Since its publication in 1998 this comprehensive text has rapidly become the standard acupuncture point book for students and practitioners throughout the English-speaking world. Detailed exposition of the names, locations, indications and actions of every point, it is characterised by hundreds of beautiful and anatomically exacting illustrations (one for every point), lengthy commentaries on the points, numerous point combinations drawn from classical texts and comprehensive indexes.
Analysis of efficacy of adding dexamethasone to ropivacaine in oral surgery

Uvod: Duža postoperativna anestezija postiže se upotrebom lokalnih anestetika dugog dejstva,kao što su ropivakain i bupivakain. U različitim hirurškim granama, duži bezbolni postoperativni period postiže se kombinacijom ropivakaina sa deksametazonom. Cilj rada bio je utvrditi kakav efekat na dužinu trajanja lokalne anestezije ima kombinacija 0,75% ropivakaina sa dodatkom deksametazona u toku i posle oralnohirurških operacija. Materijal i metode: Na Odeljenju oralne hirurgije Klinike za stomatologiju u Nišu, u toku 2017. godine, ispitivanjem je obuhvaćeno 12 pacijenata koji su podeljeni u 2 grupe: studijsku grupu od 6 pacijenata , koji su prilikom anestezije dobili 4 ml 0,75% rastvora ropivakaina i 1 ml deksazona od 4mg i kontrolnu grupu od 6 pacijenata koji su primili 4 ml 0, 75% rastvora ropivakaina. Statistička obrada podataka rađena je u programu SPSS 15.0. Rezultati:Vreme pojave prvih znakova anestezije, utvrđenih testom senzitivne osetljivosti mekih tkiva (usne i gingive) u studijskoj grupi bilo je 1,5 min, a u kontrolnoj 2,66 min. Vreme nastupanja potpune anestezije tj. potpune neosetljivosti mekih tkiva u studijskoj grupi bilo je 3,5 min, a u kontrolnoj 4,66 min. Vreme za koje su pacijenti još uvek osećali dejstvo anestezije u studijskoj grupi iznosilo je 625, 5 min što ima i statističku značajnost (p < 0.01), dok je u kontrolnoj grupi taj period bio oko 290 min. Zaključak: Male doze deksametazona dodatih lokalnom anestetiku mogu smanjiti potrebu za dodatnom anestezijom i analgetskom terapijom u prvia 24 sata posle teških oralno hirurških operacija.
Predictive Factors of Task Interdependence in the University Context

The aim of this research is to find out what type of task interdependence is generated in work teams in university contexts and to analyze the capacity to discriminate the type of task interdependence of some of the variables that are decisive for the team’s success. The sample consisted of 808 teaching students from six Spanish universities. Self-report measures were taken, such as task interdependence, attitudes towards teamwork, team potency, and social team skills. The results show that the students who carry out the tasks in teams with high interdependence are minority. However, those who work with high interdependence, present more positive attitudes towards teamwork, greater team potency, and more social skills in receiving information and self-assertion. Likewise, high interdependence would be characterized by high scores in both the attitudes and team potency. However, attitude is the variable that better discriminates the type of task interdependence, allowing for an excellent level of discrimination of high interdependence.
Petropolitics and Pipeline Diplomacy in Central Asia: Can India Afford to Wait in the Wings?

The fight for hegemony in Central Asia has existed for ages. Strategically placed between two nuclear powers—Russia and China—and geopolitically located at the heart of Eurasia, Central Asia has always remained in global limelight. Even after the disintegration of the USSR, the geopolitical importance of Central Asia never waned down, instead emerged as a grand chessboard for regional and extra-regional player for the immense opportunities it has offered in the form of widely untapped natural resources and geostrategic leverages. Importantly, it has emerged as the latest geological landscape for the energy crunch countries as potentially new and non-OPEC source of oil and natural gas. In the quest for energy security and diversity of supply sources by the energy consumers, the heartland region has witnessed a new great game in the scramble for resources. This accentuated struggle for oil and energy in the region has further led to aggressive foreign policy formulations and strategic calculation by countries like the United States, China, European Union, Japan, Israel, Iran, Pakistan and India, to which many now call as the New Great Game for not just controlling but administering the energy resources of the region. The bottom line of the New Great Game unlike the previous version is essentially played out around petropolitics and pipeline diplomacy. It is in this context this research article makes a modest attempt to examine the energy factor in the geopolitics of Central Asia and tries to figure out the position of India in the epic quest for oil in the traditional bastion of Russia and the new grand chessboard of China and the United States.