Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical indicators combined with S100A12/TLR2 signaling molecules to establish a new scoring model for coronary artery lesions in Kawasaki disease

Coronary artery lesions (CALs) are the most common and serious complication of Kawasaki disease (KD), and the pathogenesis is unknown. Exploring KD-specific biomarkers and related risk factors is significant for clinical diagnosis and treatment. This study aimed to explore the feasibility of combining clinical indicators with S100A12/TLR2-associated signaling molecules for the predictive modeling of CALs in KD. A total of 346 patients (224 males and 122 females) with KD who visited the rheumatology department of Wuhan Children’s Hospital between April 2022 and March 2025 were enrolled and divided into two groups according to the presence or absence of CALS (292 patients had CALs and 54 patients did not). Forty-one variables were collected from the two groups, including demographic characteristics, clinical manifestations, and laboratory data. Single nucleated cells from each patient were extracted, and the expression of the S100A12/TLR2 signal transduction-related molecules S100A12, TLR2, MYD88, and NF-κB were detected by real-time fluorescent quantitative polymerase chain reaction. Statistically significant variables were subjected to logistic regression analysis to determine the independent risk factors for KD with CALs, and a new risk score model was established to assess the predictive efficacy based on receiver operating characteristic curves. Sixteen variables significantly differed between the no-CALs and CALs groups: gender, fever duration, white blood cells (WBC), hemoglobin (HGB), Ce reactive protein (CRP), procalcitonin, serum ferritin (SF), erythrocyte sedimentation rate (ESR), fibrinogen (FIB), aspartate aminotransferase-to-alanine aminotransferase ratio (AST/ALT), serum albumin (ALB), sodium (Na), Interleukin (IL-10), tumor necrosis factor (TNF-α), S100 calcium binding protein A12 (S100A12), and Myeloid Differentiation Factor 88 (MYD88) (p < 0.05). After performing a univariate analysis, 12 variables (gender, fever duration, WBC, HGB, CRP, SF, ESR, FIB, AST/ALT, ALB, Na, and S100A12) were included in the multifactorial binary logistic regression, which showed that fever duration ≥ 6.5 days, ESR ≥ 46.5 mm/h, AST/ALT ≤ 1.51, and S100A12 ≥ 10.02 were independent risk factors for KD with CALs and were assigned scores of 3, 2, 1, and 2, respectively, according to the odds ratio (OR). The total score of each patient was counted, and a new prediction model for KD combined with CALs was established, where < 3.5 was considered low risk and ≥ 3.5 was regarded as high risk; the sensitivity, specificity, Jorden index, and area under the curve of this scoring system were 0.667, 0.836, 0.502, and 0.838, respectively. This new scoring model has good efficacy for predicting the occurrence of KD with CALs. The expression of S100A12 was significantly increased in the CALs group and was an independent risk factor for the occurrence of CALs, and has the potential as a biomarker for predicting KD with CALs.
Optogenetic deconstruction of sleep – wake circuitry in the brain

These homeostatic and circadian factors govern a complex, yet partially defi ned, balance between sub-cortical excitatory and inhibitory neural populations in the brain (Pace-Schott and Hobson, 2002; Fort et al., 2009). Although these wake-and sleep-active neurons are distributed throughout the brain, most of the wake-promoting neurons are found in restricted brain areas including the brainstem, the hypothalamus and the basal forebrain. Interestingly, relatively few sleep-active nuclei have been discovered, mostly restricted to the lateral hypothalamus and preoptic area. Brain arousal and sleep centers contain overlapping neuronal and non-neuronal cell types of different chemical composition and electrical properties (Gerashchenko and Shiromani, 2004), that may infl uence the sleep–wake cycle and sleep-dependent processes (Halassa et al., 2009). This heterogeneity has severely hampered our ability to record from and manipulate the neural dynamics of sleep and wake circuitry. For example, using a microelectrode to record or stimulate neural activity in brain regions known to promote sleep or wakefulness is incredibly diffi cult or even impossible given the 3D architecture of some neural populations spread out over millimeters, even in small rodents. Furthermore, the presence of multiple cell types that overlap within the same volume of tissue prevents an electrode from selectively stimulating specifi c cells of interest. New technology is clearly needed to establish causal, functional relationships between identifi ed sleep-and wake-promoting neural circuits and how these circuits interact to govern the sleep/wake cycle. We have recently used a new technology called optogenetics to selectively stimulate or inhibit specifi c neural circuits in the brain. Optogenetic tools combine the temporal precision of a microelec-trode with the spatial precision of a genetically encodable probe, allowing the stimulation or inhibition of complete populations of
A Randomised, Blinded, Placebo-Controlled Trial in Dementia Patients Continuing or Stopping Neuroleptics (The DART-AD Trial)

Background There have been increasing concerns regarding the safety and efficacy of neuroleptics in people with dementia, but there are very few long-term trials to inform clinical practice. The aim of this study was to determine the impact of long-term treatment with neuroleptic agents upon global cognitive decline and neuropsychiatric symptoms in patients with Alzheimer disease. Methods and Findings Design: Randomised, blinded, placebo-controlled parallel two-group treatment discontinuation trial. Setting: Oxfordshire, Newcastle and Gateshead, London and Edinburgh, United Kingdom. Participants: Patients currently prescribed the neuroleptics thioridazine, chlorpromazine, haloperidol trifluoperazine or risperidone for behavioural or psychiatric disturbance in dementia for at least 3 mo. Interventions: Continue neuroleptic treatment for 12 mo or switch to an identical placebo. Outcome measures: Primary outcome was total Severe Impairment Battery (SIB) score. Neuropsychiatric symptoms were evaluated with the Neuropsychiatric Inventory (NPI). Results: 165 patients were randomised (83 to continue treatment and 82 to placebo, i.e., discontinue treatment), of whom 128 (78%) commenced treatment (64 continue/64 placebo). Of those, 26 were lost to follow-up (13 per arm), resulting in 51 patients per arm analysed for the primary outcome. There was no significant difference between the continue treatment and placebo groups in the estimated mean change in SIB scores between baseline and 6 mo; estimated mean difference in deterioration (favouring placebo) −0.4 (95% confidence interval [CI] −6.4 to 5.5), adjusted for baseline value (p = 0.9). For neuropsychiatric symptoms, there was no significant difference between the continue treatment and placebo groups (n = 56 and 53, respectively) in the estimated mean change in NPI scores between baseline and 6 mo; estimated mean difference in deterioration (favouring continue treatment) −2.4 (95% CI −8.2 to 3.5), adjusted for baseline value (p = 0.4). Both results became more pronounced at 12 mo. There was some evidence to suggest that those patients with initial NPI ≥ 15 benefited on neuropsychiatric symptoms from continuing treatment. Conclusions For most patients with AD, withdrawal of neuroleptics had no overall detrimental effect on functional and cognitive status. Neuroleptics may have some value in the maintenance treatment of more severe neuropsychiatric symptoms, but this benefit must be weighed against the side effects of therapy. Trial registration: Cochrane Central Registry of Controlled Trials/National Research Register (#ISRCTN33368770).
Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment

Epigenetic mechanisms are implicated in transcriptional programs driving chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain and extraterminal (BET) proteins, which are epigenetic readers that modulate gene expression. In the phase 3 BETonMACE trial, apabetalone reduced risk of major adverse cardiac events (MACE) by 50% in the CKD subpopulation, indicating favorable effects along the kidney–heart axis. Activation of human renal mesangial cells (HRMCs) to a contractile phenotype that overproduces extracellular matrix (ECM) and inflammatory cytokines, and promotes calcification, frequently accompanies CKD to drive pathology. Here, we show apabetalone downregulated HRMC activation with TGF-β1 stimulation by suppressing TGF-β1-induced α-smooth muscle actin (α-SMA) expression, α-SMA assembly into stress fibers, enhanced contraction, collagen overproduction, and expression of key drivers of fibrosis, inflammation, or calcification including thrombospondin, fibronectin, periostin, SPARC, interleukin 6, and alkaline phosphatase. Lipopolysaccharide-stimulated expression of inflammatory genes IL6, IL1B, and PTGS2 was also suppressed. Transcriptomics confirmed apabetalone affected gene sets of ECM remodeling and integrins. Clinical translation of in vitro results was indicated in CKD patients where a single dose of apabetalone reduced plasma levels of key pro-fibrotic and inflammatory markers, and indicated inhibition of TGF-β1 signaling. While plasma proteins cannot be traced to the kidney alone, anti-fibrotic and anti-inflammatory effects of apabetalone identified in this study are consistent with the observed decrease in cardiovascular risk in CKD patients.
The Early Childhood Oral Health Impact Scale (ECOHIS): psychometric properties and application on preschoolers

Background The concept of oral health related to quality of life involves the impact that oral health has on an individual’s well-being. The Early Childhood Oral Health Impact Scale (ECOHIS) was developed to measure the impact of oral health problems on the lives of children and their families. Objective To evaluate the psychometric properties of ECOHIS applied to mothers of preschool children and estimate the influence of demographic characteristics, caries experience, and plaque index on the ECOHIS score. Methods The fit of ECOHIS to the data was assessed by confirmatory analysis. Chi-square for degrees of freedom ratio (χ2/df), Comparative Fit Index (CFI), Tucker-Lewis Index (TLI), and Root Mean Square Error of Approximation (RMSEA) were used. Reliability was estimated by the ordinal coefficients alpha (α) and omega (ω). The factorial invariance was estimated by the difference in CFI (ΔCFI). Comparisons of the ECOHIS mean scores according to the demographic characteristics, caries experience, and plaque index was performed using analysis of variance (ANOVA). Results A total of 371 children participated in the study. Mothers’ mean age was 33.0 (SD = 7.04) years. The ECOHIS presented a good fit to the data (χ2/df = 4.31; CFI = 0.95; TLI = 0.94; RMSEA = 0.09) and a strict model invariance. Children without caries and from higher income class had lower oral health impact. Conclusion The data obtained with the ECOHIS were valid, reliable, and invariant. Children with caries experience and from lower income families had a greater impact of oral problems.
A Scoping Review of Health Research with Racially/Ethnically Minoritized Adults with Intellectual and Developmental Disabilities

Living with intersectional identities, having a disability, and being a member of a racial or ethnic minoritized group in the U.S., contributes to marginalization that may result in health disparities and health inequities. The purpose of this scoping review is to describe health research regarding adult racial/ethnic minoritized individuals in the U.S with intellectual and developmental disabilities (I/DD). Eight electronic databases were searched to identify literature on the topic published since 2000. Of the 5,229 records, 35 articles were included in the review. Eligible studies included research conducted in the U.S., published in English, and research focused on adults with I/DD with race and/or ethnicity information. The 35 articles included racial/ethnic minoritized individuals who were Black, Latinx/Hispanic, American Indian, and Asian. Twenty-nine of the 35 articles identified health disparities experienced by adults with I/DD from racial/ethnic minoritized groups. Many health disparities were demonstrated in the articles, where adult racial/ethnic minoritized individuals with I/DD fared worse compared to White adults with I/DD. Additionally, four articles describe differences in health experiences by those from racial or ethnic minoritized backgrounds. Results of this scoping review highlight the need for research that incorporates intentional inclusion of racial/ethnic minoritized people with I/DD and include novel methodologies that allow for the contributions of historically marginalized voices. Future research with an intersectionality approach is recommended to promote equity.
Gradual evolutionary transformations of ontogeny in an Ordovician ostracod lineage

Carapace morphology was studied biometrically for each instar in a series of populations of Mojczella Olempska 1988 from the Ordovician strata exposed in Mojcza, Holy Cross Mountains, Poland. Phosphatic coatings of ostracod valves occur there in abundance from the top of the Arenig to the Late Caradoc. The lineage shows smooth acceleration in ontogenetic expression of the junction of crests C1 and C3, which originally were separated throughout the ontogeny, while in the latest populations the separation was preserved only in the earliest moult stage. Moreover, the velar structure, being originally developed as a wide, slightly convex, flange-like dolon in heteromorphs, became transformed into a convex dolon.
Nurse-Led Randomized Controlled Trials in the Perioperative Setting: A Scoping Review

Purpose Nurses provide care at each phase of the complex, perioperative pathway and are well placed to identify areas of care requiring investigation in randomized controlled trials. Yet, currently, the scope of nurse-led randomized controlled trials conducted within the perioperative setting are unknown. This scoping review aims to identify areas of perioperative care in which nurse-led randomized controlled trials have been conducted, to identify issues impacting upon the quality of these trials and identify gaps for future investigation. Methods This scoping review was conducted in reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. Searches were conducted in PubMed, Embase, Cumulative Index for Nursing and Allied Health Literature and the Cochrane Central Register of Controlled Trials, with a date range of 2014–19. Sources of unpublished literature included Open Grey, and ProQuest Dissertation and Theses, Clinical Trials.gov and the Australian and New Zealand Clinical Trials Registry. After title and abstract checking, full-text retrieval and data extraction, studies were appraised using the Joanna Briggs Institute Critical Appraisal Checklists for randomized controlled trials. Data were synthesized according to the main objectives. Key information was tabulated. Results From the 86 included studies, key areas where nurses have led randomized controlled trials include patient or caregiver anxiety; postoperative pain relief; surgical site infection prevention: patient and caregiver knowledge; perioperative hypothermia prevention; postoperative nausea and vomiting; in addition to other diverse outcomes. Issues impacting upon quality (including poorly reported randomization), and gaps for future investigation (including a focus on vulnerable populations), are evident. Conclusion Nurse-led randomized controlled trials in the perioperative setting have focused on key areas of perioperative care. Yet, opportunities exist for nurses to lead experimental research in other perioperative priority areas and within different populations that have been neglected, such as in the population of older adults undergoing surgery.
Initiation of magmatism during the Cambrian-Ordovician Ross orogeny in southern Victoria Land, Antarctica

Sensitive high-resolution ion-microprobe (SHRIMP) U-Pb zircon dating of four gneissic granitoid intrusions, whose field relationships indicate that they are among the oldest plutonic rocks exposed in the Dry Valleys region of southern Victoria Land, Antarctica, gives ages between 531 ± 10 and 502 ± 9 Ma. Two samples from 1- to 3-km-scale gneissic plutons characterized by the distinctive enrichment in Sr and depletion in Y (DV1b suite) typical of "adakitic" igneous rocks yielded dates of 531 ± 10 Ma and 516 ± 10 Ma, respectively. Two other samples of gneissic, K-feldspar– megacrystic granodiorite intercalated with the Skelton Group country rocks that are characterized by more typical Cordilleran I-type chemistries (DV1a suite) yielded dates of 505 ± 9 Ma and 502 ± 9 Ma, respectively. A fifth sample from the large Bonney pluton (DV1a suite) emplaced at the peak of magmatic activity during the Ross orogeny, gave a date of 499 ± 6 Ma. The new dates indicate that subduction and magmatism associated with the Ross orogeny had begun by ca. 530 Ma along this segment of the East Antarctic margin. They also require cessation by this time of the Neoproterozoic–Cambrian rifting that predated the Ross orogeny. None of the gneissic granitoid plutons was emplaced during a Neoproterozoic Beardmore orogeny, as has been suggested by some previous workers. Emplacement of small plutons characterized by an "adakitic" chemistry, punctuated by folding events, continued for 10–30 m.y. after ca. 530 Ma before major, more typical Cordilleran-style magmatism occurred between 505 and 499 Ma. Large volumes of calc-alkalic plutonic rocks in the Ross orogen south of the Dry Valleys region were emplaced 10–40 m.y. earlier than those in the Dry Valleys region, indicating marked variations in the timing of calc- alkalic granitoid magmatism parallel to the Ross orogen. The full extent and significance of these variations remain to be defined.
Study on the use of omega-3 fatty acids as a therapeutic supplement in treatment of psoriasis

: Previous studies have suggested a benefit for patients with plaque psoriasis when omega-3 fatty acids are added to topical treatment. This study evaluated the efficacy of a nutritional complement rich in omega-3 fatty acids in patients with mild or moderate plaque psoriasis. Thirty patients were recruited, 15 of whom were given topical treatment with tacalcitol, forming the control group. The remaining 15 patients were given topical tacalcitol and 2 capsules of Oravex ® daily. Three visits, the baseline, intermediate (week 4), and final (week 8), were held over an 8-week period. The main efficacy endpoints were the Psoriasis Area and Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI) and Dermatological Life Quality Index (DLQI). A clear and significant improvement was observed in all the efficacy endpoints in both groups between the baseline visit and the end visit. This improvement was significantly greater in the group treated additionally with Oravex ® than in the control group. Supplementary treatment with omega-3 fatty acids complements topical treatment in psoriasis, and makes a significant contribution to reducing PASI and NAPSI and improving DLQI; and to reducing scalp lesion
Association between malaria and undernutrition among pregnant women at presentation for antenatal care in health facilities in the Mount Cameroon region

In resource limited settings, malaria and undernutrition are major public health problems in pregnancy. Therefore, this study assessed the association between malaria infection and undernutrition among pregnant women in the Mount Cameroon area. This cross-sectional study enrolled 1,014 pregnant women consecutively over a year. A structured questionnaire was used to collect socio-demographic information and clinical data. Maternal nutrition was assessed using dietary diversity (DD). Peripheral blood samples collected were used for the diagnosis of malaria parasitaemia by microscopy whereas haemoglobin (Hb) levels were determined using an Hb meter. Logistic regression was used to determine factors associated with malaria and dietary diversity. The prevalence of malaria infection and undernutrition was 17.8% and 89.6% respectively. In addition, of those infected with malaria, geometric mean parasite density was 301/μL of blood (range: 40–9280) while mean DD score was 3.57±0.82 (range: 1–7). The odds of being infected with malaria parasitaemia was highest among women enrolled in the rainy season (OR = 1.58, P = 0.043), who were farmers (OR = 2.3, P = 0.030), had a household size of < 4 individuals (OR = 1.48, P = 0.026) and who were febrile (OR = 1.87, P < 0.001). Also, attending clinic visits in Mutengene Medical Centre (OR = 2.0, P = 0.012) or Buea Integrated Health Centre (OR = 2.9, P = < 0.001), being < 25 years (OR = 2.4, P = 0.002) and a farmer (OR = 10.6, P = 0.024) as well as < 4 clinic visits (OR = 1.62, P = 0.039) were identified as predictors of undernutrition. Furthermore, the association between malaria and DD was statistically significant (P = 0.015). In this study, undernutrition was highly frequent than malaria infection. Thus, there is an urgent need to improve maternal awareness through nutritional counselling and health campaigns on the benefits of consuming at least five food groups. Besides, improved maternal dietary nutrient intake is likely to have impact on the burden of malaria parasite infection.
Including climate feedbacks in regional water resource assessments

Two important changes to the meteorological conditions can occur as a result of a change in the landsurface state: the precipitation can change (Koster et al, 2004, Wang et al, 2007) and the evaporative demand can change (Ek and Holtslag, 2004, Schubert et al, 2004). Precipitation is particularly difficult to predict as it can be affected by large-scale weather patterns or complex processes such as mesoscale circulations or convective processes. The physics involved and the scale and complexity of the processes means that complex numerical atmospheric models are usually necessary to quantify impact of the land surface on precipitation, although a simple, analytical model can sometimes be used to assess the effect of the land- surface state on the likelihood of triggering convective precipitation (e.g., De Ridder, 1997). Changes in the evaporative demand are equally important. For instance, Cai et al (2009) have demonstrated the role that the land-atmosphere feedbacks have had on the recent Australian drought. The feedback link between the land surface and the evaporative demand is through the Planetary Boundary Layer (PBL) and this feedback process lends itself to a fairly simple analysis. A framework to assess the impact of change in the land surface on the evaporative demand, and subsequent available regional water resources is proposed in this report. This report addresses the following questions: 1. How do the feedbacks from the planetary boundary layer (PBL) control the surface water balance? What would happen if there were no feedbacks? 2. How much does land-cover to atmosphere feedbacks control the surface water balance? 3. How does irrigation change the atmospheric conditions? 4. How much does atmospheric CO2 affect the water-use? The tools and data we use to address these questions are selected Earth Observation fields, river and evaporation flux data to validate the land surface models, vertical profiles of temperature and humidity that control the evolution of the PBL, and various models: from 1-dimensional slab models of the PBL, 2-dimensional models of the land surface and 3-dimensional models of the surface and atmosphere. The four questions are addressed by quantifying the land-atmosphere feedbacks and the impacts of those feedbacks on the land-surface water balance using a unified framework.