Miracle-dz/UniFAR-FTUs huggingface dataset:
Leveraging shark‐fin consumer preferences to deliver sustainable fisheries

At least one third of sharks and their cartilaginous relatives (Class Chondrichthyes) meet the IUCN Red List Criteria for being threatened with extinction. Overfishing is the primary threat, with less than 4% of the world's shark catches managed for sustainability. The high‐value shark‐fin trade has gained the greatest attention as a conservation issue, yet there has been little research on shark‐fin consumer preferences, and how these might be leveraged to deliver sustainability goals. We used an online discrete choice experiment to explore preferences for price, quality, rarity, and finning among 2914 shark‐fin soup consumers in China. Overall, consumers prefer higher priced and rare shark‐fins, obtained without finning, yet we found three distinct groups with substantial heterogeneity between them. Our results provide evidence for the conspicuous consumption nature of shark‐fin use, but also suggest these preferences could be leveraged to incentivize responsible shark fishing. In addition, messaging for future unsustainable demand reduction should focus on shark‐finning and animal welfare as opposed species rarity and extinction.
When Shooting for the Stars Becomes Aiming for Asterisks: P-Hacking in Family Business Research

As a side-effect of increasing publication pressures, academics may be tempted to engage in p-hacking: a questionable research practice involving the iterative and incompletely-disclosed adjustment of data collection, analysis, and/or reporting, until nonsignificant results turn significant. Prior studies in entrepreneurship-related disciplines carry the implicit notion that p-hacking is predominantly an issue in top-tier journals, where incentives to do so may be highest. This study investigates p-hacking in the family business literature, a research field with roots in the broader entrepreneurship and small business literatures, and in which discourse increasingly takes place in both dedicated field journals and in the top-tier outlets in entrepreneurship and management. Analyses of p-values published in these field- and top-tier journals allow for a comparison of the prevalence and correlates of p-hacking at these different levels of prestige. The findings suggest that p-hacking is an issue of substantial—and statistically indistinguishable—magnitudes in both field- and top-tier journals. We further observe negative correlations of female authorship and employer prestige with p-hacking, where the latter is stronger in field versus top-tier journals. Implications of these findings, their limitations, and some suggestions going forward are discussed, with particular attention for the promise of preregistration and registered reports.
Molecular phylogeny reveals a new genus of freshwater mussels from the Mekong River Basin (Bivalvia: Unionidae)

A new genus of freshwater mussels (Bivalvia: Unionidae) is described from the Mekong River Basin as Namkongnaia gen. nov. The validity of the new genus is supported by its unique conchological characteristics, namely the lack of hinge dentition and elongated shells, together with its evolutionary distinctiveness as estimated by multi-locus phylogenetic analyses (mitochondrial COI and 16S, and nuclear 28S genes). The new genus includes two lineages with deep divergence, shown by 5.10% uncorrected COI p-distance. One lineage is a type species described herein as Namkongnaia inkhavilayi gen. et sp. nov. The other is a recognized species under the name ‘Pilsbryoconcha lemeslei (Morelet, 1875)’. Molecular phylogenetic analysis further shows that the new genus belongs to the tribe Pseudodontini, and evolutionarily is closely related to the genus Monodontina Conrad, 1853. However, its conchology is similar to the genus Pilsbryoconcha Simpson, 1900. Time-calibrated phylogeny suggests that the main radiation events of the tribe Pseudodontini occurred during the Late Cretaceous to the Eocene, with the divergence between the new genus and Monodontina placed in the Miocene. The discovery of new freshwater mussel taxa in this study highlights the importance of the Mekong River Basin as one of the world’s biodiversity hotspots for freshwater fauna.
Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients

Background. It is still unclear whether COVID-19 convalescent kidney transplant recipients (KTR) and hemodialysis (HD) patients can develop anti-SARS-CoV-2 adaptive immunity. The aim was to characterize and compare the immune response to the virus in HD patients and KTR. Methods. The study included 26 HD patients and 54 KTR—both convalescent (14 HD, 25 KTR) and unexposed. The immune response was assessed by determining the anti-SARS-CoV-2 antibodies in serum and specific T cell response via the interferon-gamma release assay (IGRA). Moreover, blood-morphology-derived parameters, immune cell phenotypes, and acute phase reactants were evaluated. Results. KRT and HD convalescents presented similar serum levels of anti-SARS-CoV-2 IgG and IgA. A negative correlation occurred between IgG and time after the infection was observed. There was a strong relationship between the prevalence of anti-SARS-CoV-2 cellular and humoral responses in both groups. Convalescent IGRA response was significantly higher in HD patients compared to KTR. Conclusions. HD patients and KTR develop humoral and cellular responses after COVID-19. The antibodies levels are similar in both groups of patients. SARS-CoV-2-reactive T cell response is stronger in HD patients compared to KTR. The SARS-CoV-2-specific IgG level decreases with time while IgA and a cellular response are maintained. IGRA proved to be a valuable test for the assessment of specific cellular immunity in immunocompromised HD patients and KTR.
Murine models of sickle cell disease and beta-thalassemia demonstrate pulmonary hypertension with distinctive features

Sickle cell anemia and β-thalassemia intermedia are very different genetically determined hemoglobinopathies predisposing to pulmonary hypertension. The etiologies responsible for the associated development of pulmonary hypertension in both diseases are multi-factorial with extensive mechanistic contributors described. Both sickle cell anemia and β-thalassemia intermedia present with intra and extravascular hemolysis. And because sickle cell anemia and β-thalassemia intermedia share features of extravascular hemolysis, macrophage iron excess and anemia we sought to characterize the common features of the pulmonary hypertension phenotype, cardiac mechanics, and function as well as lung and right ventricular metabolism. Within the concept of iron, we have defined a unique pulmonary vascular iron accumulation in lungs of sickle cell anemia pulmonary hypertension patients at autopsy. This observation is unlike findings in idiopathic or other forms of pulmonary arterial hypertension. In this study, we hypothesized that a common pathophysiology would characterize the pulmonary hypertension phenotype in sickle cell anemia and β-thalassemia intermedia murine models. However, unlike sickle cell anemia, β-thalassemia is also a disease of dyserythropoiesis, with increased iron absorption and cellular iron extrusion. This process is mediated by high erythroferrone and low hepcidin levels as well as dysregulated iron transport due transferrin saturation, so there may be differences as well. Herein we describe common and divergent features of pulmonary hypertension in aged Berk-ss (sickle cell anemia) and Hbbth/3+ (intermediate β-thalassemia) mice and suggest translational utility as proof-of-concept models to study pulmonary hypertension therapeutics specific to genetic anemias.
Characterization of Marine Organism Extracellular Matrix-Anchored Extracellular Vesicles and Their Biological Effect on the Alleviation of Pro-Inflammatory Cytokines

Representative marine materials such as biopolymers and bioceramics contain bioactive properties and are applied in regenerative medicine and tissue engineering. The marine organism-derived extracellular matrix (ECM), which consists of structural and functional molecules, has been studied as a biomaterial. It has been used to reconstruct tissues and improve biological functions. However, research on marine-derived extracellular vesicles (EVs) among marine functional materials is limited. Recent studies on marine-derived EVs were limited to eco-system studies using bacteria-released EVs. We aimed to expand the range of representative marine organisms such as fish, crustaceans, and echinoderms; establish the extraction process; and study the bioactivity capability of marine EVs. Results confirmed that marine organism ECM-anchored EVs (mEVs) have a similar morphology and cargos to those of EVs in land animals. To investigate physiological effects, lipopolysaccharide (LPS)-infected macrophages were treated with EVs derived from sea cucumber, fish, and shrimp. A comparison of the expression levels of inflammatory cytokine genes revealed that all types of mEVs alleviated pro-inflammatory cytokines, although to different degrees. Among them, the sea cucumber-derived EVs showed the strongest suppression ability. This study showed that research on EVs derived from various types of marine animals can lead to the development of high value-added therapeutics from discarded marine wastes.
Recent progress on the study of multi‐vehicle coordination in cooperative attack and defense: An overview

Cooperative guidance and control design of multiple vehicles plays an important role in obtaining benefits of cooperation for enhancement of combat effectiveness in modern military. A number of efficient cooperative strategies have been developed in literature within this context. This paper aims to provide a detail overview of the theoretical advances toward multi‐vehicle coordination for cooperative attack and defense. With a focus on the pertinent literature published in the past two decades, this topic is divided into two categories, namely, terminal‐time coordination and multiplayer pursuit‐evasion. The recent progress of these two categories is systematically reviewed, and a short discussion on future research perspectives is also presented.
Effect of COVID-19 Pandemic-Induced Dietary and Lifestyle Changes and Their Associations with Perceived Health Status and Self-Reported Body Weight Changes in India: A Cross-Sectional Survey

Home confinement during the COVID-19 pandemic is accompanied by dramatic changes in lifestyle and dietary behaviors that can significantly influence health. We conducted an online cross-sectional survey to assess COVID-19 pandemic-induced dietary and lifestyle changes and their association with perceived health status and self-reported body weight changes among 1000 Indian adults in early 2021. Positive improvements in dietary habits, e.g., eating more nutritious (85% of participants) and home-cooked food (89%) and an increase in overall nutrition intake (79%), were observed. Sixty-five percent of participants self-reported increased oat consumption to support immunity. There were some negative changes, e.g., more binge eating (69%), eating more in between meals (67%), and increasing meal portion size (72%). Two-thirds of participants reported no change in lifestyles, whereas 21 and 23% reported an increase, and 13 and 10% reported a decrease in physical activity and sleep, respectively. Overall, 64 and 65% of participants reported an improvement in perceived health and an increase in body weight during the COVID-19 period compared to pre-COVID-19, respectively. The top motivations for improving dietary habits included improving physical and mental health and building immunity. In conclusion, the overall perceived health was improved and there was an increase in self-reported body weight in most participants during COVID-19. Diet emerged as the most crucial determinant for these changes.
Discrimination study between the carcass and non-carcass components for interaction between gender, age, and production system in indigenous sheep

The objective of this work was to evaluate the yields, morphometric measures, carcass, and non-carcass components, and carcass regional and tissue composition of an indigenous sheep (Pantaneiro) of different physiological stages (gender, age, system production. Thirty sheep, eleven lambs, nine wethers, and ten cull ewes were used. The lambs were finished in feedlots, the wethers were maintained on pastures and supplementation, and the cull ewes were maintained on an extensive pasture system with mineral salt ad libitum. Slaughter ages were defined to simulate the most representative products and farming systems. Animals were slaughtered and classified as non- castrated lambs, wethers, and cull ewes. The criteria to slaughter lambs and wethers were the body condition, which ranged from 2.5 to 3.0. Cull ewes were slaughtered based on negative pregnancy diagnosis, regardless of their body condition, which ranged from 4.0 to 4.5. All animals were slaughtered after 16-hours of fasting (solids). The ewes presented the greatest fat thickness, differing significantly from the lambs. The morphometric measures were higher in ewes and lambs. The muscle to fat ratio of the animal’s cuts from different physiological stages presented no significant differences. The indigenous Pantaneiro sheep have good potential for meat production regardless of their physiological stages. The ewes stood out, presenting carcasses with good performance considering their potential and longer permanence in the herd due to their reproductive function.
A case for addressing the unresolved role of permeable shelf sediments in ocean denitrification

The marine nitrogen cycle is a main driver of ocean productivity and affects global climate. Despite decades of study, we still have an incomplete understanding of the role of the marine nitrogen cycle in the Earth system. While marine sediments play a major role in nitrogen cycling in the ocean, magnitudes and mechanisms are largely unconstrained. Recent research suggests that permeable sandy sediments on the highly energetic and dynamic continental shelf are key components of the marine nitrogen cycle, but data to quantify their contribution are lacking. Here, we use insights from measurements and modeling studies to substantiate the hypothesis that shelf sediments are an overlooked driver of the marine nitrogen cycle. Specifically, we propose that permeable shelf sediments are sites for intense nitrogen conversions and suggest a three‐pronged approach to address unresolved controversies.
Political and ideological normalization: quality of government, mainstream-right ideological positions and extreme-right support

Abstract This article aims to explain the variation in the electoral support for extreme-right parties (ERPs) in Europe. The extant literature on the far-right party family does not answer this question specifically with regard to the extreme-right variants for two main reasons. Firstly, theories did not expect the electoral success of these parties in post-war Europe due to their anti-democratic profiles and association with fascism. Secondly, despite the fact that they acknowledge the differences between the parties under the far-right umbrella – namely, the extreme and the radical – they normally do not take these differences into account, and if so, they focus on the radical-right parties. This article shows that electoral support for ERPs is associated with low quality of government and highly conservative mainstream-right parties. The former creates political legitimization for anti-democratic parties and the latter ideological normalization of extreme right.
Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency

Several members of the Hes/Her family, conserved targets of the Notch signalling pathway, encode transcriptional repressors that dimerise, bind DNA and self-repress. Such autoinhibition of transcription can yield homeostasis and, in the presence of delays that account for processes such as transcription, splicing and transport, oscillations. Whilst previous models of autoinhibition of transcription have tended to treat processes such as translation as being unregulated (and hence linear), here we develop and explore a mathematical model that considers autoinhibition of transcription together with nonlinear regulation of translation. It is demonstrated that such a model can yield, in the absence of delays, nonlinear dynamical behaviours such as excitability, homeostasis, oscillations and intermittency. These results indicate that regulation of translation as well as transcription allows for a much richer range of behaviours than is possible with autoregulation of transcription alone. A number of experiments are suggested that would that allow for the signature of autoregulation of translation as well as transcription to be experimentally detected in a Notch signalling system.
Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia

Macrophages are a heterogeneous population with both pro- and anti-inflammatory functions play an essential role in maintaining tissue homeostasis, promoting inflammation under pathological conditions, and tissue repair after injury. In pulmonary hypertension, the M1 phenotype is more pro-inflammatory compared to the M2 phenotype, which is involved in tissue repair. The role of macrophages in the initiation and progression of pulmonary hypertension is well studied. However, their role in the regression of established pulmonary hypertension is not well known. Rats chronically exposed to hemoglobin (Hb) plus hypoxia (HX) share similarities to humans with pulmonary hypertension associated with hemolytic disease, including the presence of a unique macrophage phenotype surrounding distal vessels that are associated with vascular remodeling. These lung macrophages are characterized by high iron content, HO-1, ET-1, and IL-6, and are recruited from the circulation. Depletion of macrophages in this model prevents the development of pulmonary hypertension and vascular remodeling. In this study, we specifically investigate the regression of pulmonary hypertension over a four-week duration after rats were removed from Hb + HX exposure with and without gadolinium chloride administration. Withdrawal of Hb + HX reversed systolic pressures and right ventricular function after Hb + Hx exposure in four weeks. Our data show that depleting circulating monocytes/macrophages during reversal prevents complete recovery of right ventricular systolic pressure and vascular remodeling in this rat model of pulmonary hypertension at four weeks post exposure. The data presented offer a novel insight into the role of macrophages in the processes of pulmonary hypertension regression in a rodent model of Hb + Hx-driven disease.
The importance of relationality: A note on co‐determinism, multispecies relationships and implications for COVID‐19

Abstract The paper aims to highlight the importance of subjective, objective and intersubjective domains when engaging in public education and research on wicked problems such as violence, poverty, climate change, loss of habitat and pandemics. The case is made that critical systemic thinking and practice—underpinned by a meta Design of Inquiring Systems—could help to foster a more relational response to the convergent social, economic and environmental policy challenges that pose ‘existential risks’. This paper explores the implications of ‘mismeasuring our lives’ by not understanding relationality. It reflects on the factors that are linked with the ‘unravelling’ of well‐being, in order to prevent and restore the multispecies relationships that have been forgotten. This requires a bio‐political approach to reframing not only economics but our relationships with one another and with nature. ‘Power and knowledge are linked’ and nowhere is Foucault's linkage more marked than in the biopolitical determination of what species are valued and why. Taxonomies are constructs based on values that need to be carefully considered in terms of the consequences of policy decisions.
From Hematopoietic Stem Cell Transplantation to Chimeric Antigen Receptor Therapy: Advances, Limitations and Future Perspectives

Chimeric antigen receptor (CAR) T-cell therapy was envisioned as a mechanism to re-direct effector T-cells to eliminate tumor cells. CARs are composed of the variable region of an antibody that binds a native cancer antigen coupled to the signaling domain of a TCR and co-stimulatory molecules. Its success and approval by the U.S. Food and Drug Administration for the treatment of B-cell malignancies revolutionized the immunotherapy field, leading to extensive research on its possible application for other cancer types. In this review, we will focus on the evolution of CAR-T cell therapy outlining current technologies as well as major obstacles for its wide application. We will highlight achievements, the efforts to increase efficacy and to evolve into an off-the-shelf treatment, and as a possible future treatment for non-cancer related diseases.
Relationship of Internet Addiction with Alexithymia and Childhood’s Perceived Parenting in University Students

Electronic media are integral part of everyday life and undoubtedly facilitate it on multiple levels. Internet is a useful work, knowledge (Papanikolaou, Makri, Magoulas, Chinou, Georgalas & Roussos, 2016), entertainment and information tool, but its limitless range often proves unsafe for the user. The present study, focuses on the relationship among web addiction, alexithymia and childhood’s perceived parenting while controlling for the indirect effect of depression. For the aims of the present study, 206 Greek University students attending Social, Exact Sciences and Ηumanities Departments, mean age 21, filled in a battery of measures; the Young’s Internet Addiction Test IAT (Young, 1998), the Toronto Alexithymia scale (Bagby, Parker & Taylor, 1994) the Center for Epidemiologic Studies Depression scale CES - D (Radloff, 1977), the Parental Bonding Instrument PBI of Parker, Tupling and Brown (1979) and a demographics form. Alexithymia presents significant direct association with Internet addiction, while the factors which mediate this relationship remain unclear. Findings are being discussed towards a possible review of the instruments measuring Internet addiction, as well as towards an approach of electronic media addiction from a different perspective with broader implications in therapeutic practice.
Studying the Relationship between Performance and Z-Scores for Manufacturing Firms in Singapore

Singapore is a key leading economy in the Asia Pacific region. This study examines the relationship between the financial health, as measured by the Altman Z-Score, and corporate performance, as measured by the Return on Equity (ROE), of listed manufacturing companies in this market. A linear regression has been conducted between these variables to determine the magnitude and direction of their relationships. The trends of Z-Scores over a five-year period have also been analysed. The analysis covers the period from 2013 to 2017 (inclusive) and yields a statistically positive correlation between ROE and the Z-Score for the market. Singapore registered relatively moderate-to-healthy mean and median Z-Scores. These findings further support the strong economic position of this market in Asia.