Miracle-dz/UniFAR-FTUs huggingface dataset:
Sodium Butyrate as Adjuvant Therapy with Mycophenolate Mofetil for Amelioration of Skin Fibrosis in Bleomycin-induced Scleroderma in Mice via Immunomodulatory, Antioxidant, Antiapoptotic and Antifibrotic Mechanisms

Background: Scleroderma is an autoimmune, multi-organ disease; its clinical hallmark is cutaneous and systemic fibrosis. Up to date, there is no definite cure. Aim of the Study: The aim of this study was to investigate the potential effects of sodium butyrate (NaB), and mycophenolate mofetil (MMF) each alone or both in a mice model of scleroderma induced by bleomycin (BLM), and to clarify some of their possible mechanisms on oxidative stress, immunological pattern, apoptosis, inflammation and fibrosis. Methods: This study was carried out on 50 Balb/C mice, divided into 5 equal groups. Serum levels of anticentromere antibody (ACA), and skin tissue levels of the following parameters were assayed: transforming growth factor-β1 (TGF-β1), interleukin-4 (IL-4), malondialdehyde (MDA), and superoxide dismutase (SOD). Tissue sections were examined for histopathological changes, dermal thickness, and immunohistochemical expression of caspase- 3, and α-smooth muscle actin (α-SMA). Results and Conclusion: The combined group showed a significant decline in TGF-β1, IL-4, MDA levels, caspase-3, and α-SMA, as well as a significant increase in SOD. Moreover, marked reduction in dermal fibrosis and dermal thickness compared to monotherapy by either NaB or MMF. The combination of NaB and MMF is a promising candidate for the treatment of scleroderma.
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora

Background Diabetic ulcer remains a clinical challenge due to impaired angiogenesis and persistent inflammation, requiring new alternative therapies to promote tissue regeneration. Purpose In this study, chitosan/sodium alginate/velvet antler blood peptides (CS/SA/VBPs) hydrogel (CAVBPH) was fabricated and used in the treatment of skin wounds in type 2 diabetes mellitus (T2D) for the first time. Methods VBPs were prepared by hydrolysis and ultrafiltration, and their sequences were identified using LC-MS/MS. The CAVBPH was further fabricated and characterized. A mouse model of T2D was induced by a high-sugar and high-fat diet (HSFD) and streptozotocin (STZ) injection. CAVBPH was applied topically to T2D wounds, and its effects on skin repair and potential biological mechanisms were analyzed by appearance observation, histopathological staining, bioinformatics analysis, Western blot, and 16S rRNA sequencing. Results VBPs had numerous short-chain active peptides, excellent antioxidant activity, and a low hemolysis rate. CAVBPH exhibited desirable biochemical properties and participated in the diabetic wound healing process by promoting cell proliferation (PCNA and α-SMA) and angiogenesis (capillaries and CD31) and alleviating inflammation (CD68). Mechanistically, the therapeutic effect of CAVBPH on chronic wounds might rely on activating the PI3K/AKT/mTOR/HIF-1α/VEGFA pathway and reversing the expression of inflammatory cytokines TNF-α and IL-1β. The results of 16S rRNA sequencing indicated that T2D significantly altered the diversity and structure of skin flora at the wound site. CAVBPH treatment elevated the relative abundance of beneficial microbes (e.g., Corynebacterium_1 and Lactobacillus) and reversed the structural imbalance of skin microbiota. Conclusion These results indicate that CAVBPH is a promising wound dressing, and its repair effect on diabetic wounds by regulating angiogenesis, inflammatory response, and skin flora may depend on the rich small peptides in VBPs.
Comment on "Investigation of simplified thermal expansion models for compressible Newtonian fluids applied to nonisothernal plane Couette and Poiseuille flows" by S. Bechtel et al

In the above paper by Bechtel, Cai, Rooney and Wang, Physics of Fluids, 2004, 16, 3955-3974 six different theories of a Newtonian viscous fluid are investigated and compared, namely, the theory of a compressible Newtonian fluid, and five constitutive limits of this theory: the incompressible theory, the limit where density changes only due to changes in temperature, the limit where density changes only with changes in entropy, the limit where pressure is a function only of temperature, and the limit of pressure a function only of entropy. The six theories are compared through their ability to model two test problems: (i) steady flow between moving parallel isothermal planes separated by a fixed distance with no pressure gradient in the flow direction (Couette flow), and (ii) steady flow between stationary isothermal parallel planes with a pressure gradient (Poiseuille flow). The authors found, among other, that the incompressible theory admits solutions to these problems of the plane Couette/Poiseuille flow form: a single nonzero velocity component in a direction parallel to the bounding planes, and velocity and temperature varying only in the direction perpendicular to the planes.
II Consensus of the Brazilian Nutrology Association on DHA recommendations during pregnancy, lactation and childhood

Objective: To update of the consensus of the Brazilian Association of Nutrology regarding DHA consumption and supplementation during pregnancy, lactation and childhood. Methods: Scientific articles published until 2022 were reviewed in Pubmed/Medline, SciELO and Lilacs databases. Results: Considering the information obtained, the authors drafted the consensus, which was approved by the Brazilian Association of Nutrology board. Conclusions: The recommendations of the Brazilian Nutrology Association are presented based on scientific evidence.
The Effectiveness of High-Frequency Repetitive Transcranial Magnetic Stimulation on Patients with Neuropathic Orofacial Pain: A Systematic Review of Randomized Controlled Trials

Background Repetitive transcranial magnetic stimulation (rTMS) has been widely used in the treatment of neuropathic orofacial pain (NOP). The consistency of its therapeutic efficacy with the optimal protocol is highly debatable. Objective To assess the effectiveness of rTMS on pain intensity, psychological conditions, and quality of life (QOL) in individuals with NOP based on randomized controlled trials (RCTs). Methods We carefully screened and browsed 5 medical databases from inception to January 1, 2022. The study will be included that use of rTMS as the intervention for patients with NOP. Two researchers independently completed record retrieval, data processing, and evaluation of methodological quality. Quality and evidence were assessed using the PEDro scores and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results Six RCTs with 214 participants were included in this systematic review: 2 studies were considered level 1 evidence, and 4 were considered level 2 evidence. Six studies found that high-frequency rTMS had a pain-relieving effect, while 4 studies found no improvement in psychological conditions and QOL. Quality of evidence (GRADE system) ranged from moderate to high. No significant side effects were found. Conclusions There is moderate-to-high evidence to prove that high-frequency rTMS is effective in reducing pain in individuals with NOP, but it has no significant positive effect on psychological conditions and QOL. High-frequency rTMS can be used as an alternative treatment for pain in individuals with NOP, but further studies will be conducted to unify treatment parameters, and the sample size will be expanded to explore its influence on psychological conditions and QOL.
Developing Organizational Agility in SMEs: An Investigation of Innovation’s Roles and Strategic Flexibility

Although social capital and collaborative knowledge creation were considered essential drivers in maintaining competitive advantage, empirical evidence on the impact of collaborative knowledge creation on organizational agility remained limited. Therefore, this study examined the relationship between social capital and collaborative knowledge creation in building innovation and agility and testing strategic flexibility as a moderating variable. It employed a quantitative design by distributing questionnaires to 414 managers and assistant managers of SMEs analyzed by SmartPLS-SEM. The results showed that social capital significantly affected collaborative knowledge creation, innovation, and organizational agility. Meanwhile, collaborative knowledge creation has no significant impact on organizational agility. Furthermore, strategic flexibility was not a moderating variable of the relationship between innovation and organizational agility. Based on these findings, this study produced recommendations for managers to strengthen organizational agility.
Do the Number, Size, and Position of Partially Threaded Screws Affect the Radiological Healing of Surgically Treated Displaced Femoral Neck Fractures? A Review of 136 Children

Background and Objectives: The quantity, size, and position of implants might affect the fracture healing process of surgically treated displaced pediatric femoral neck fractures (PFNFs). The aim of this retrospective multicenter study was to evaluate the correlation between the time needed to achieve radiological union and the number, size, and location of the partially threaded cannulated screws (PTCSs) in children with displaced PFNFs. Materials and Methods: A retrospective review of 136 children (mean age: 10.6 ± 3.8 years) with displaced PFNFs treated by two (n = 103) or three (n = 33) PTCSs was carried out. Student’s t-tests, one-way ANOVA, Cox regression analysis, and multiple linear regression analyses were performed to investigate the variables affecting the time needed to achieve radiological fracture healing according to the number, size, and position of PTCSs, as assessed on plain radiographs. Results: A total of 132 hips achieved union at an average of 3.2 ± 1.6 months after the initial surgery. The time needed to achieve union in the patients treated with two or three PTCSs was comparable (p = 0.36). Among the fractures treated by two PTCSs, the time needed to achieve union did not correlate with the size of the implant (p = 0.122), or with the angulation between the PTCSs on anterior–posterior (p = 0.257) and lateral radiographs (p = 0.547). The time needed to achieve union in the fractures that were fully compressed by the implants was similar to the partially compressed fractures (p = 0.08). Conclusions: The number, size, and position of the PTCSs do not affect the radiological healing in the children with displaced PFNFs treated surgically.
Psychological therapies and non-suicidal self-injury in LGBTIQ in accident and emergency departments in the UK: a scoping review

Abstract Background To identify psychological interventions that improve outcomes for those who overdose, especially amongst Lesbian, Gay, Bisexual, Transgender, Intersex and Questioning populations. Objective To recognize and assess the results from all studies including randomized control trials (RCTs) that have studied the efficiency of psychiatric and psychological assessment of people who have depression that undergo non-suicidal self-injury (NSSI) by self-poisoning, presenting to UK Accident and Emergency Departments. Method A scoping review of all studies including RCTs of psychiatric and psychological therapy treatments. Studies were selected according to types of engagement and intervention received. All studies including RCTs available in databases since 1998 in the Wiley version of the Cochrane controlled trials register in 1998 till 2021, Psych INFO, Medline, Google Scholar and from manually searching of journals were included. Studies that included information on repetition of the NSSI behaviour were also included. Altogether this amounts to 3900 randomized study participants with outcome data. Results Seven trials reported repetition of NSSI as an outcome measure which were classified into four categories. Problem-solving therapy is indicated as a promising therapy and has shown to significantly reduce repetition in participants who NSSI by overdosing than patients in the control treatment groups consisting of standard after care. Conclusion The data show that manualized cognitive therapy psychological intervention was more effective than TAU after care. However, these differences are not statistically significant with p = . 15; CI 0.61, 1.0 which crosses the line of no effect. And psychodynamic interpersonal therapy is more effective than the standard treatment. Despite being only one study in this subgroup the analysis shows a statistical significance with p = . 009, CI 0.08; 0.7.
Fracture Resistance and Microleakage around Direct Restorations in High C-Factor Cavities

The aim of this research was to evaluate the mechanical impact of different direct restorations in terms of fracture resistance, and subsequent fracture pattern, in occlusal high C-factor cavities. Furthermore, the adaptation of different direct restorations in the form of gap formation was also evaluated. Seventy-two intact mandibular molars were collected and randomly distributed into three groups (n = 24). Class I occlusal cavities with standardized dimensions were prepared in all specimens. After adhesive treatment, the cavities were restored with direct restorations utilizing three different materials. Group 1: layered conventional packable resin composite (Filtek Ultimate), Group 2: bulk-fill resin composite (SDR), Group 3: bulk-fill short fibre-reinforced composite (SFRC; everX Posterior) covered with packable composite occlusally. Half of the restored specimens underwent static load-to fracture testing (n = 12/group), while the rest underwent sectioning and staining for microleakage evaluation and gap formation analysis. Fracture patterns were evaluated visually among the mechanically tested specimens. The layered composite restoration (Group 1) showed significantly lower fracture resistance compared to the bulk fill groups (Group 2, p = 0.005, Group 3, p = 0.008), while there was no difference in fracture resistance between the other groups. In terms of gap formation values, the layered composite restoration (Group 1) produced significantly higher gap formation compared to the bulk-fill groups (Group 2, p = 0.000, Group 3, p = 0.000). Regarding the fracture pattern, SFRC (Group 3) produced the highest number, while SDR (Group 2) produced the lowest number of repairable fractures. The use of bulk-fill resin composite (fibre or non-fibre-reinforced) for occlusal direct restorations in high C-factor cavities showed promising achievements regarding both fracture resistance and microleakage. Furthermore, the use of short fibre-reinforced bulk-fill composite can also improve the fracture pattern of the restoration-tooth unit. Bulk-fill materials provide a simple and effective solution for restoring and reinforcing high C-factor occlusal cavities.
Landing Gear Noise Identification Using Phased Array with Experimental and Computational Data

In regard to aircraft noise mitigation, this paper focuses on noise emission by a simplified nose landing gear (NLG), whose noise sources are identified by the means of sensor array methods. More precisely, following a former characterization of the aeroacoustics by the NLG via dedicated experiments and computations, the subsequent experimental and numerical noise signals are applied two popular sensor array methods of noise localization, namely, classical beam forming (CBF) and deconvolution approach for the mapping of acoustic sources (DAMAS). The resulting noise source maps are then analyzed from both the points of view of phenomenology (NLG noise generation mechanisms) and methodology (noise localization methods and application). The results show how sensor array methods (more especially DAMAS) are capable of revealing the underlying physics of the NLG noise source mechanisms, whether it is within an experimental or a computational context. This speaks in favor of a more systematic use of sensor array.
Squat Detection of Railway Switches and Crossings Using Wavelets and Isolation Forest

Railway switches and crossings (S&Cs) are critical, high-value assets in railway networks. A single failure of such an asset could result in severe network disturbance and considerable economical losses. Squats are common rail surface defects of S&Cs and need to be detected and estimated at an early stage to minimise maintenance costs and increase the reliability of S&Cs. For practicality, installation of wired or wireless sensors along the S&C may not be reliable due to the risk of damages of power and signal cables or sensors. To cope with these issues, this study presents a method for collecting and processing vibration data from an accelerometer installed at the point machine to extract features related to the squat defects of the S&C. An unsupervised anomaly-detection method using the isolation forest algorithm is applied to generate anomaly scores from the features. Important features are ranked and selected. This paper describes the procedure of parameter tuning and presents the achieved anomaly scores. The results show that the proposed method is effective and that the generated anomaly scores indicate the health status of an S&C regarding squat defects.
Preparation and Study of Composite Materials of the NiAl-Cr-Mo-Nanoparticles (ZrO2, MgAl2O4) System

Materials based on the NiAl-Cr-Mo system with zirconium oxide or aluminum-magnesium spinel nanoparticle small additions were obtained by spark plasma sintering. Thermodynamic modeling was carried out to predict the phase formation in the NiAl-Cr-Mo system and its change depending on temperature, considering the presence of a small amount of carbon in the system. The phase composition and microstructure of materials were studied. NiAl (B2) and CrMo phases were found in the sintered samples. Bending strength measurements at different temperatures shows that nanoparticles of insoluble additives lead to an increase in bending strength, especially at high temperatures. A fractographic analysis of the sample’s fractures shows their hybrid nature and intercrystalline fracture, which is confirmed by the clearly visible matrix grains similar to cleavage. The maximum strength at 700 °C (475 MPa) was found for material with the addition of 0.1 wt. % zirconium oxide nanoparticles. In the study of internal friction, typical peaks of a nickel-aluminum alloy were found in the temperature ranges of 150–200 °C and 350–400 °C.
Risk‐reducing mastectomy decisions among women with mutations in high‐ and moderate‐ penetrance breast cancer susceptibility genes

Women harboring mutations in breast cancer susceptibility genes are at increased lifetime risk of developing breast cancer and are faced with decisions about risk management, including whether to undergo high‐risk screening or risk‐reducing mastectomy (RRM). National guidelines recommend BRCA1 or BRCA2 mutation carriers consider RRM, but that carriers of moderate penetrance mutations (e.g., ATM or CHEK2) should be managed based on family history. We aimed to investigate determinants of decision for RRM, and hypothesized that mutation status, age, family history, partner status, and breast cancer would impact RRM decision making.
Clopidogrel-Associated Interstitial Lung Disease: A Case Report and Literature Review

Clopidogrel is an antithrombotic agent widely used for the secondary prevention of cerebrovascular and cardiovascular complications. Clopidogrel can cause serious adverse events, including gastrointestinal bleeding. Pulmonary complications caused by clopidogrel are not widely described, and clopidogrel-induced interstitial lung disease (ILD) is rare. Here, we report a case of drug-induced ILD in a patient who presented with dyspnea, chest pain, and mild fever. The patient underwent percutaneous coronary intervention two months ago and was commenced on clopidogrel. He was diagnosed with clopidogrel-induced ILD based on clinical and imaging findings, history of drug exposure without any change, exclusion of other respiratory disorders, and clinical improvement after discontinuation of clopidogrel and steroid use.
Prediction Models for Estimating Compressive Strength of Concrete Made of Manufactured Sand Using Gene Expression Programming Model

The depletion of natural resources of river sand and its availability issues as a construction material compelled the researchers to use manufactured sand. This study investigates the compressive strength of concrete made of manufactured sand as a partial replacement of normal sand. The prediction model, i.e., gene expression programming (GEP), was used to estimate the compressive strength of manufactured sand concrete (MSC). A database comprising 275 experimental results based on 11 input variables and 1 target variable was used to train and validate the developed models. For this purpose, the compressive strength of cement, tensile strength of cement, curing age, Dmax of crushed stone, stone powder content, fineness modulus of the sand, water-to-binder ratio, water-to-cement ratio, water content, sand ratio, and slump were taken as input variables. The investigation of a varying number of genetic characteristics, such as chromosomal number, head size, and gene number, resulted in the creation of 11 alternative models (M1-M11). The M5 model outperformed other created models for the training and testing stages, with values of (4.538, 3.216, 0.919) and (4.953, 3.348, 0.906), respectively, according to the results of the accuracy evaluation parameters root mean square error (RMSE), mean absolute error (MAE), and coefficient of determination (R2). The R2 and error indices values revealed that the experimental and projected findings are in extremely close agreement. The best model has 200 chromosomes, 8 head sizes, and 3 genes. The mathematical expression achieved from the GEP model revealed that six parameters, namely the compressive and tensile strength of cement, curing period, water–binder ratio, water–cement ratio, and stone powder content contributed effectively among the 11 input variables. The sensitivity analysis showed that water–cement ratio (46.22%), curing period (25.43%), and stone powder content (13.55%) were revealed as the most influential variables, in descending order. The sensitivity of the remaining variables was recorded as w/b (11.37%) > fce (2.35%) > fct (1.35%).
Model Theoretic Algebra with particular emphasis on Fields, Rings, Modules

Introduction, ultraproducts, definitions and examples elementary equivalence - axiomatizable and finitely axiomatizable classes - examples and results in field theory elementary definability - applications to polynomial and power series rings and their quotient fields peano rings and peano fields hilbertian fields and realizations of finite groups as galois groups the language of modules over a fixed ring algebraically compact modules decompositions and algebraic compactness the two sorted language of modules over unspecified rings the first order theory of rings pure global dimension and algebraically compact rings representation theory of finite dimensional algebras problems tables basic notions and definitions from homological algebra functor categories on finitely presented modules.