Miracle-dz/UniFAR-FTUs huggingface dataset:
Antimicrobial activity of actinomycetes and characterization of actinomycin-producing strain KRG-1 isolated from Karoo, South Africa

In the present study we reported the antimicrobial activity of actinomycetes isolated from aridic soil sample collected in Karoo, South Africa. Eighty-six actinomycete strains were isolated and purified, out of them thirty-four morphologically different strains were tested for antimicrobial activity. Among 35 isolates, 10 (28.57%) showed both antibacterial and antifungal activity. The ethyl acetate extract of strain KRG-1 showed the strongest antimicrobial activity and therefore was selected for further investigation. The almost complete nucleotide sequence of the 16S rRNA gene as well as distinctive matrix-assisted laser desorption/ionization-time-of-flight/mass spectrometry (MALDI-TOF/MS) profile of whole-cell proteins acquired for strain KRG-1 led to the identification of Streptomyces antibioticus KRG-1 (GenBank accession number: KX827270). The ethyl acetate extract of KRG-1 was fractionated by HPLC method against the most suppressed bacterium Staphylococcus aureus (Newman). LC//MS analysis led to the identification of the active peak that exhibited UV-VIS maxima at 442 nm and the ESI-HRMS spectrum showing the prominent ion clusters for [M-H2O+H] at m/z 635.3109 and for [M+Na]+ at m/z 1269.6148. This information could be assigned to chromopeptide lactone antibiotic actinomycin. Our results suggest that unexplored soils could be an interesting source for exploring antibacterial secondary metabolites.
Methionine Adenosyltransferase 1: A Proteomic Surrogate Marker of Early Hepatocellular Carcinoma in Cirrhotic Patients

Methionine Adenosyltransferase 1: A Proteomic Surrogate Marker of Early Hepatocellular Carcinoma in Cirrhotic Patients Joo Ho Lee, Mi Jung Jun, Ju Hyun Shim, Gi-Won Song, Eunyoung Tak, Bora Oh, Eunsil Yu, Sang-Woon Choi, Jihyun An, Danbi Lee, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Young-Hwa Chung, Yung Sang Lee Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam; Department of Gastroenterology, Department of Surgery, Asan Institute for Life Sciences, and Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Production and perception asymmetries in the Canadian vowel shift

In this paper we report the results of an experiment we carried out in order to investigate expressive language in Down Syndrome (DS). Research has shown that during pre-school and school years, children with DS use expressive skills processes and sound patterns that are similar to those used by typically developing children. However, they eliminate these processes at a slower rate. In view of the above we conducted an experiment so as to investigate expressive language skills in forty five children with DS and forty five children with typical development in order to compare and contrast their language development. Our results showed that children with DS present more expressive language impairments in the Greek language than their typically developing counterparts.
BODY MASS INDEX AS A PROGNOSTIC FACTOR FOR DISEASE PROGRESSION IN PATIENTS WITH METASTATIC COLORECTAL CANCER TREATED WITH BEVACIZUMAB BASED SYSTEMIC THERAPY.

Context Epidemiological data have shown that obesity increases the risk of developing colorectal cancer and also an increased body mass index (BMI) is associated with a worse prognosis. Bevacizumab based systemic therapy, an antiVEGF targeted therapy, is an important treatment option for metastatic colorectal cancer (mCRC) patients. Obesity is associated with high level of vascular endothelial growth factor (VEGF), that might provoke resistance to antiVEGF monoclonal antibody. Objective To evaluate the efficacy in terms of progression free survival (PFS) and overall survival (OS) of bevacizumab systemic therapy in patients with mCRC. Design Retrospective cohort, single center study. Subjects and Methods Between January 2007 and December 2012, 112 patients with mCRC, who followed bevacizumab based systemic therapy in the "Ion Chiricuta" Oncology Institute in Cluj-Napoca, were included in our analysis. Results Values of BMI ≥ or <27 kg/sqm was found that PFS is statistically significant superior in patients with BMI<27 kg/sqm (n=77) than in those with BMI ≥ 27 kg/sqm (n=35), 24 months versus 17.9 months (p = 0.04). Five years OS was not influenced by the BMI, 35% vs 30% (p=0.29). In patients with liver metastases with values of BMI ≥ 27 kg/sqm have PFS lower than patients with a BMI <27 kg/sqm, 17.5 months versus 24.5 months (p = 0.02). Five years OS was not influenced by the BMI, 39% (BMI <27 kg/sqm) vs. 22% (BMI ≥ 27 kg/sqm) (p = 0.09). Conclusions This study demonstrated the negative influence of BMI on both PFS on the entire sample of patients and in patients with liver metastases only, BMI cut-off value proved to be 27 kg/square meter and shows that the BMI may be an important prognostic factor with a high clinical relevance in patients with mCRC.
Molecular profiling of EGFR pathway according to location of colorectal cancer (CRC): Analysis of 1,001 patients in single institute.

3597 Background: Location of colon cancer (right-sided versus left-sided) was reported as a predictor of benefit from cetuximab in the subanalysis of NCIC CTG CO.17 trial. On the other hand, retrospective analyses have identified KRAS including codon61, codon146, BRAF, NRAS, or PIK3CA mutations as potentially negative predictive factors for anti EGFR treatments. This analysis aimed to reveal the prevalence of these mutations in the EGFR pathway according to location of CRC in a large cohort. Methods: Consecutive patients of 1,001 CRC from January 2012 to October 2013 were analyzed in this study. Multiplex genotyping of EGFR pathway was performed on archival samples using Luminex Assay (MABGEN and GENOSEARCH Mu-PACK, MBL) for KRAS including codons 61 and 146, BRAF, NRAS, and PIK3CA. We examined the correlation among mutation profile, clinical data and location of CRC. Statistical analysis was conducted by chi-square test. Results: The incidence of mutations; KRAS codon12 and 13, codon61 and 146, BRAF, NRAS.
Wideband Spectrum Sensing in Cognitive Radio using Uniform and Non Uniform Filter Banks

Rapid growth in wireless communication services has increased the demand for spectrum resources. A recent report by Federal Communications Commission (FCC) reveals the fact that major part of the spectrum is underutilized. The existing static frequency allocation schemes are not able to accommodate the requirements of increasing data rate and wireless services. Such scenarios demand innovative techniques to exploit the available spectrum. Cognitive Radio (CR) techniques have proven to be a solution to alleviate the spectrum scarcity using spectrum sensing techniques. In this thesis, we focus on wideband spectrum sensing using ﬁ lter bank techniques. Even though narrowband spectrum sensing makes a binary decision on the whole spectrum, it is unable to identify spectral holes and spectral opportunities within a wideband spectrum. On the other hand, in wideband spectrum sensing, the available bandwidth is divided into multiple subbands or subchannels for spectrum sensing. A solution to this would be ﬁ lter bank spectrum sensing. Filter banks can be derived using modulation of a single prototype ﬁ
Misconduct in Organizations

Insider misconduct, such as financial misconduct and privacy breaches, has received an increasing amount of public scrutiny in recent years. Empirical studies have argued that employee seniority plays a role in insider misconduct. Our study provides intuitions for these empirical findings and insights into how regulations can be designed to improve social welfare. We model the interactions between lawmakers, organizations, and their employees under the risk of insider misconduct. Employees are the source of insider threats. Firms interact with employees and enforce a certain level of monitoring. Lawmakers influence other parties’ incentives by imposing legal penalties. We study the interaction among the three parties in a two-stage game model. In the first stage, we analyze an optimization problem where the lawmakers decide the penalties to employees for engaging in misconduct and firms for overlooking this behavior. In the second stage, we analyze a simultaneous game where the firms decide the monitoring effort and employees decide whether to engage in misconduct and study the comparative statics. We derive closed-form solutions to the equilibriums in the second stage. We show how monitoring and misconduct change with respect to financial incentives and employee seniority. Under regularity conditions, we formulate an optimization problem for the lawmakers as a linear optimization problem. Our model helps explain empirical evidence that middle management and top management typically cause large-scale misconduct. From a welfare point of view, a seniority-based penalty for misconduct is better than a uniform penalty. In addition, stiff penalties are not necessarily more helpful than a milder regulation.
Black African Nurses' Experiences of Equality, Racism, and Discrimination in the National Health Service

As the workforce in the British National Health Service (NHS) has become more diverse, several researchers have reported that experiences of overseas nurses have been largely negative. This paper explores Black African nurses' experiences of equal opportunities, racism, and discrimination in four NHS trusts in northeastern England. Thirty nurses from sub-Saharan countries working in four NHS trusts were interviewed between 2006 and 2008 using semistructured interviews and focus group discussions to gain an insight into their experiences in the NHS. This study suggests that Black African nurses experienced discrimination and racism from White colleagues and other overseas nurses, managers, and patients and their relatives as well as lack of opportunities in their workplaces. Managers seemed to treat British and other overseas nurses more favorably than Black African nurses. Although much progress has been made in valuing and embracing diversity in the NHS, this article highlights areas in which more work is required.
Formal model of Parkinson’s disease neurons unveils possible causality links in the pathophysiology of the disease

Parkinson’s Disease is the second most common neurodegenerative disease after Alzheimer’s disease. Despite extensive research, the initial cause of the disease is still unknown, although substantial advances were made in understanding of its genetics and the cognate neurophysiological mechanisms. Determining the causality relationships and the chronological steps pertaining to Parkinson’s Disease is essential for the discovery of novel drug targets. We developed a systematic in silico model based on available data, which puts the possible sequence of events occurring in a neuron during disease onset into light. This is the first ever attempt, to our knowledge, to model comprehensively the primary modifications in the molecular pathways that manifest in compromised neurons from the commencement of the disease to the consequences of its progression. We showed that our proposed disease pathway was relevant for unveiling yet incomplete knowledge on calcium homeostasis in mitochondria, ROS production and α-synuclein misfolding. Graphical abstract Highlights Varying calcium concentration in aging dopaminergic neurons triggers disease onset. ROS production in the mitochondria potentially causes iron accumulation. Iron homeostasis dysregulation is linked to α-synuclein aggregation.
Faktor Risiko Kepatuhan Kemoterapi pada Pasien Kanker Payudara

The prevalence of cancer in Indonesia is significantly high. Based on data (Rikesdas) in 2013, it showed that the prevalence of cancer is 1,4 per 1000 people or approximately 330.000 people. The most popular cases faced by women is chest and cervix cancer. Data has shown that 75% of breast cancer had chemotherapy. The result of studies shows that more than 60% of chemotherapy patient caused hair fall, darken-nail, queasy, and loss appetite. The aim of this study was to find out factors related to the obedience to chemotherapy on breast cancer patients in wardThursina II BLUD Zainal Abidin Hospital Banda Aceh in 2017. This research was conducted from 1 April to 30 May 2017. This type of research was the correlation with crossectional study design approach. The population of the study included all of the breast cancer patients who were having chemotherapy. The technique of sampling used was accidental sampling that involved 65 participants. Data were analyzed using Chi-Square Test. The result of the study showed that there was a relationship self-concept and chemotherapy obedience (p-value=0,013); expense and chemotherapy obedience (p-value=0,036); family support and chemotherapy obedience (p-value=0,002); side-effects and chemotherapy obedient (p-value=0,007). It is hoped that all the employee in BLUD dr.Zainal Abidin Hospital Banda Aceh can improve nursing management and enhance operational standard procedure on chemotherapy for patients, especially for breast cancer patients.
DETERMINASI TECHNOLOGY ACCEPTANCE MODEL TERHADAP NIAT PENGGUNAAN FINTECH SEBAGAI ALAT PEMBAYARAN (PAYMENT)

Penerapan teknologi dalam transaksi pembayaran seperti yang dilakukan perusahaan fintech harus memperhatikan aspek perilaku. Aspek perilaku tersebut tercermin dalam Technology Acceptance Model (TAM). Tujuan Penelitian ini untuk mengetahui pengaruh beberapa variable Technology Acceptance Model (TAM) dan pengaruh kepercayaan serta risiko terhadap niat menggunakan fintech dalam pembayaran transaksi. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan data primer. Peneliti memperoleh data dengan menyebarkan kuisioner kepada 108 mahasiswa Manajemen Fakultas Ekonomi Universitas Tidar untuk mengetahui pengaruh setiap variable. Peneliti menggunakan uji validitas nilai Corrected Item-Total Correlation dan Uji Cronbach Alfa untuk pengujian realibilitas. Data-data dianalisis dengan menggunakan metode regresi linear berganda. Hasil penelitian menunjukkan bahwa pengaruh persepsi kemudahan penggunaan, persepsi manfaat, persepsi kepercayaan, persepsi risiko terhadap niat penggunaan fintech dalam bertransaksi secara simultan berpengaruh signifikan. Demikian juga secara parsial, masing-masing variable berpengaruh terhadap niat penggunaan fintech dalam bertransaksi dan realibilitas dengan menggunakan uji regresi linear berganda
Alien species stabilize local fisheries catch in a highly invaded ecosystem

Alien species may be a valuable resource for marine fisheries, yet their contribution to the catch might be balanced by negative effects on indigenous species. In this study, we explored a unique high-resolution time series of catch data from a highly invaded ecosystem in the eastern Mediterranean. We analyzed over 5000 fishing hauls digitalizing from fishers’ logbooks. We found that the catch per unit effort (CPUE) of alien species increased over time, while for indigenous species, CPUE remained relatively stable between 1996 and 2013. This suggests a lack of competitive exclusion of indigenous target species due to the proliferation of alien species. From the perspective of the fishers’ revenues, alien species gradually became a more important part of the catch, while overall fishers’ revenues showed temporal stability. This was the combined result of alien species increasing CPUE and fishers shifting their effort toward shallower water where alien species were dominant. Our findings demonstrate that alien species can become a valuable resource for a local fishing industry with little effect on indigenous species, which is highly relevant to worldwide fisheries experiencing range redistribution of commercial species.
Corporate governance and performance of medium-sized firms in Nigeria: does sustainability initiative matter?

Purpose The non-existence of the corporate governance (CG) concept for practices by non-financial medium-sized firms (MSFs) in Nigeria informed. This study aims to determine whether CG practices influence firms’ performance and whether sustainability initiative (SI) mediates the relationship between CG and MSFs’ performance in Nigeria. Design/methodology/approach A total of 300 firms were selected on convenience sampling basis from South Western Nigeria using a structured questionnaire. The authors used Statistical Package for Social Sciences for exploratory data analysis and hypotheses were tested using covariance-based structural equation modelling. Findings The results show that CG has a significant positive effect on performance [financial performance (FNP) and non-financial performance (NFP)] and SI. SI has a mixed impact on performance, e.g. a significant positive impact on NFP but insignificant negative impact on FNP. Similarly, SI has a combined mediating effect in the relationship between CG and performance, e.g. fully mediates CG → NFP and does not mediate CG → FNP. Firms are to invest in social and environmental initiatives substantially. CG codes will complement the International Financial Reporting Standards for MSFs. Research limitations/implications This study supports the assumptions of theories (institutional, stakeholder and agency) as the basis for the usage of multiple approaches to determine the outcome of hypotheses, especially in developing climes. Practical implications The study contributes to CG and performance literature by examining the mediating effects of SI. The paper also shows the necessity to emphasise NFP aspect. Policymakers should evolve CG codes to encourage stakeholders to believe more in the corporate existence of MSFs for strengthening capital-base and quality personnel engagement. Originality/value To the best of the authors’ knowledge, this is one of the first empirical attempts showing the evidence on the relationship between CG and NFP in Nigeria.
Promoting Healthy Lifestyles in Urban and Rural Elders

The daily or frequent practice of health promotion activities by elders is critical to maximize health, decrease disabilities, and enhance well-being. The purposes of this descriptive correlational study was to (a) determine differences in 244 urban and rural elders and (b) relationships among health promotion activities, perceived health, functional health, perceived level of social support, and demographic characteristics. Data were analyzed using descriptive and linear regression to determine that the perceived level of social support was the significant predictor variable for the overall practice of health promotion. Race and functional health were significant predictors of lesser degree. The activities of exercise, nutrition, safety, and substance use were significant to urban and rural elders with different predicator variables for each activity. Keywords: health promotion, perceived health, functional health, social support, urban, rural, elders http://dx.doi. org/10.14574/ojrnhc.v1i2. 490
Modified hematological sepsis score in early diagnosis of neonatal sepsis

Background: Diagnosis of neonatal sepsis at an early stage substantially reduces the mortality. The clinician often relies on laboratory parameters to support the clinical suspicion. As blood culture takes time and yield is low, hematological and biochemical parameters often guide to the diagnosis and management. Rodwell’s Hematological sepsis score (HSS) has a reasonable sensitivity but low specificity. Some of the parameters included in that scoring system are repetitive of same pathogenic mechanism. A modified HSS was developed by the authors by removing the repetitive parameters, increasing the weightage for low neutrophil count and adding a new parameter nucleated RBC. Objective of the study was to compare the diagnostic ability of the modified hematological sepsis score with Rodwell’s hematological sepsis score. Methods: Prospective analytical study conducted in a tertiary level hospital. Neonates admitted to NICU and had complete blood count done were included. Babies with clinical signs of systemic inflammatory response syndrome and evidence of organ dysfunction were considered septic. They were classified as proven sepsis if the blood culture was positive. All the samples were scored for both HSS and modified HSS. The sensitivity, specificity and other diagnostic ability tests were compared between the two scoring systems. Results: Total of 75 neonates were enrolled. 25 of them had sepsis and three had blood culture positive. At a score of 3, the sensitivity and specificity of HSS was 80 and 70% and that of Modified HSS was 84 and 82% respectively. Conclusions: Modified hematological score improves the specificity and likelihood ratios without decreasing the sensitivity in early diagnosis of neonatal sepsis.
The contribution of a master’s degree to clinical practice

Method: We conducted three focus group interviews with anaesthesiology and intensive care nurses in three health trusts. They were managers, advanced practice nurse mentors, experienced nurses and recent nursing graduates. We used thematic content analysis to analyse and interpret meaning systems. The expectations of informants regarding master’s level competence were gleaned from the positive and negative statements made during the interviews.
Application of a biomechanical model and combinatorial optimization to determine lower limb joints torsional stiffness in human landing

Lower limb joint’s torsional stiffness is directly related to the individual’s performance and probability of injury when landing. There are various methods of calculating ankle, knee, and hip joint’s torsional stiffness in which the reliability of the achieved values by them are highly controversial. The purpose of this research is to provide a new method of calculating lower limb joint’s active torsional stiffness based on the body’s four-degrees-of-freedom biomechanical model. For this purpose, a group of subjects performs single-leg landing protocol from the box. In this method, the biomechanical model’s equations of motion are derived in the sagittal plane and are combined with a combinatorial optimization algorithm, which consists of genetic and simulated annealing. By the use of acquired data from the force plate and motion analysis system, combinatorial genetic algorithm–simulated annealing algorithm tries to minimize the differences between the model’s ground reaction force (GRFModel) and the GRFExperimental for each subject and thereby the joint’s torsional stiffness values are obtained. Results show that calculating lower limb joint’s torsional stiffness using the proposed method has good ability in simulating the GRFExperimental in the model. Also, the obtained values by the proposed method have moderate to good reliability and desirable variability in the measurements. Comparing the obtained stiffness values with the values of three conventional computation method in the literature shows that those common methods’ results have high computational errors, low reliability, and high variability in the measurement. Also, their ability to produce GRFModel similar to the GRFExperimental is weaker than the proposed method in single-leg landing protocol.