Miracle-dz/UniFAR-FTUs huggingface dataset:
Childhood Friendship Experiences and Cognitive Functioning in Later Life: The Mediating Roles of Adult Social Disconnectedness and Adult Loneliness.

BACKGROUND AND OBJECTIVES This study investigated the relationship between childhood friendships and cognitive functioning, as assessed with cognitive status and decline among adults aged 45 and older in China. We also examined the mediating effect of adult social disconnectedness and adult loneliness for this relationship. RESEARCH DESIGN AND METHODS This study was based on 3 waves of data from the China Health and Retirement Longitudinal Study (CHARLS; 2011, 2013, 2015; N = 13,959). Cognitive functioning was assessed with episodic memory. Childhood friendship measures were taken from the 2014 life history module of the CHARLS. Two dimensions of adult social isolation, loneliness and social disconnectedness, were included as mediators. Latent growth curve modeling was utilized to test the associations between childhood friendships, adult social isolation, and cognitive functioning. RESULTS Adverse childhood friendship experiences were found to be significantly associated with both lower initial cognitive status and the rate of decline in cognitive functioning. Our findings indicated that adult loneliness and social disconnectedness partly mediated the link between childhood friendship experiences and the initial level of cognitive functioning, but not cognitive decline later in life. DISCUSSION AND IMPLICATIONS The findings emphasized the enduring importance of childhood friendships for cognitive functioning later in life. Interventions that focus on improving social participation through fostering friendships in childhood may have long-term benefits for cognition later in life.
Analysis of relationship between sows colostrum and milk somatic cell count and reproductive performance traits

Summary. The relationship between the major chemical constituents and somatic cell count (SCC) in sows colostrum and milk and the rearing results of piglets was analyzed. The studies involved 20 crossbred Polish Large White (PLW)  Polish Landrace (PL) sows in the second and third reproduction cycles. The chosen reproductive performance traits were plotted against the level of each chemical composition component and the SCC of colostrum (1 lactation day) and milk (7 lactation day). The chemical composition of sows colostrum and milk as well as the SCC estimates proved to be significantly modified by the lactation stage and season. It was also found that a higher share of the major components of sows colostrum and milk with the lower SCC favored the higher litter size and piglet usability for rearing expressed as body weight and daily weight gains.
The Estrous Cycle and Induction of Ovulation in Mares

For horse breeders or managers, it is critical to understand the estrous cycle of mares. Breeding of mares cannot be successfully achieved throughout the whole year as mares breed seasonally. Mares are only able to breed when day length is more than 16 h, and this period is known as the breeding season. Their estrous cycle is approximately 21 days with 5-7 days of estrus and 14 to 15 days of a diestrus period. The estrous cycle of the mare is mainly controlled by gonadotropins, which control follicular development and ovulation. Mares exhibit unique ovulatory events which are not observed in other species. A LH surge occurs for several days, with levels of LH reaching their peak after ovulation. The LH level at the time of LH peak is lower than most other species. The unique anatomical structure of the ovaries of mares is known to limit the number of eggs ovulated. Several attempts have been made to develop chemical/hormonal agents which might be used to manipulate the timed ovulation of mares. Agents that have been tested include hCG, native GnRH, Deslorelin (Ovuplant, GnRH-agonist), Buserelin (GnRH analogue), equine pituitary extracts and equine chorionic gonadotropin (eCG or PMSG). However, the function, purity or stability of these agents is not reliable. Recombinant equine LH, an alternative agent for the timed ovulation, has been developed and tested for its biological activities, through the use of both in vitro and in vivo experiments. The reLH was suggested to be a reliable agent in inducing ovulation within 48 h after being administered through injection, when the size of dominant follicle is 35 mm in diameter.
Accentuated Eccentric Loading and Cluster Set Configurations in the Bench Press

Abstract Lates, AD, Greer, BK, Wagle, JP, and Taber, CB. Accentuated eccentric loading and cluster set configurations in the bench press. J Strength Cond Res 36(6): 1485–1489, 2022—This study was designed to examine the kinetic and kinematic differences between an Accentuated eccentric loading (AEL), traditional loading, and cluster sets in trained male subjects (age: 23.7 ± 4.0 years, height: 176.4 ± 2.8 cm, mass: 93.6 ± 7.0 kg) with lifting experience (training age: 7.2 ± 2.4 years, 1-repetition maximum (1RM) bench press: 125.0 ± 14.8 kg, relative strength ratio: 1.3 ± 0.1) in the bench press. Subjects reported for a total of 5 sessions which consisted of a 1RM testing session and 4 experimental trials. The 4 experimental conditions consisted of a traditional load (TRAD), traditional load with inter-repetition rest (TRDC), accentuated eccentric loading with inter-repetition rest (AELC), and Accentuated eccentric loading for the first repetition only (AEL1). Concentric load was 80% of subjects' 1RM for all conditions. An eccentric overload of 105% of 1RM was applied using weight-releasing hooks during the AEL conditions. TRDC demonstrated superior concentric outputs for mean velocity and mean power compared with TRAD, AELC, and AEL1 (p < 0.001). In addition, AEL1 produced significantly greater effects for rate of force development compared with TRDC (p < 0.001). These findings suggest that inter-repetition rest had an influence on concentric performance, specifically mean power and mean velocity, and may be favorable when using higher loads and when sustained power outputs are desired. In addition, AEL1 may provide a unique eccentric stimulus that alters loading parameters compared with traditional loading conditions.
Family growth response to different laboratory culture environments shows genotype–environment interaction in the sea urchin Strongylocentrotus intermedius

This study investigated the genetic variation and genotype–environment interaction (GEI) in the early growth stage among seven full-sib families of the sea urchin Strongylocentrotus intermedius. From each of the seven families, 180 or 270 sea urchins of the same size were exposed to three laboratory environments (E1, E2 and E3). These environments were commonly used in breeding programs for S. intermedius. After a 102 days trial, test height, test diameter, body weight and the coefficient of variation of body weight were determined. The results revealed significant family effects on most growth traits in all the three environments (except for test diameter in environment E2), and significant environmental effects on growth in several families (family 1, 5, 6, 7). The study also revealed that the coefficient of variation in body weight varied significantly among the families (P 0.05). Variances of GEI accounted for about 0–2.742% of phenotypic variances for the investigated traits. Significant GEI caused a certain degree family ranking inversions for the growth traits. The present study provides evidence for the existence of GEI in the family selection of sea urchin S. intermedius. More attention should be paid to the GEI to obtain satisfactory genetic gain in S. intermedius.
The developmental neural substrates of Hebb repetition learning and their link with reading ability

Abstract Hebb repetition learning is a fundamental learning mechanism for sequential knowledge, such as language. However, still little is known about its development. This fMRI study examined the developmental neural substrates of Hebb repetition learning and its relation with reading abilities in a group of 49 children aged from 6 to 12 years. In the scanner, the children carried out an immediate serial recall task for syllable sequences of which some sequences were repeated several times over the course of the session (Hebb repetition sequences). The rate of Hebb repetition learning was associated with modulation of activity in the medial temporal lobe. Importantly, for the age range studied here, learning‐related medial temporal lobe modulation was independent of the age of the children. Furthermore, we observed an association between regular and irregular word reading abilities and the neural substrates of Hebb repetition learning. This study suggests that the functional neural substrates of Hebb repetition learning do not undergo further maturational changes in school age children, possibly because they are sustained by implicit sequential learning mechanisms which are considered to be fully developed by that age. Importantly, the neural substrates of Hebb learning remain significant determinants of children's learning abilities, such as reading.
Predator-released compounds, ambient temperature and competitive exclusion among differently sized Daphnia species

1. We studied the effects of fish water and temperature on mechanisms of competitive exclusion among two Daphnia species in flow-through microcosms. The large-bodied D. pulicaria outcompeted the medium sized D. galeata × hyalina in fish water, but not in the control treatment. Daphnia galeata × hyalina was competitively displaced 36 days earlier at 18 °C than at 12 °C. 2. It is likely that the high phosphorus content of fish water increased the nutritional value of detrital seston particles by stimulating bacterial growth. Daphnia pulicaria was presumably better able to use these as food and hence showed a more rapid somatic growth than its competitor. This led to very high density of D. pulicaria in fish water, but not in the controls. The elevated D. pulicaria density coincided with high mortality and reduced fecundity in D. galeata × hyalina, resulting in c 3. It is clear that the daphnids competed for a limiting resource, as grazing caused a strong decrease in their seston food concentration. However, interference may also have played a role, as earlier studies have shown larger Daphnia species to be dominant in this respect. The high density of large-bodied D. pulicaria in fish water may have had an allelopathic effect on the hybrid. Our data are inconclusive with respect to whether the reached seston concentration was below the threshold resourc 4. Our results do clearly show that fish-released compounds mediated competitive exclusion among zooplankton species and that such displacement occurred at a greatly enhanced rate at an elevated temperature. Fish may thus not only structure zooplankton communities directly through size-selective predation, but also indirectly through the compounds they release. [KEYWORDS: density dependence ; detritus ; exploitative competition ; interference competition nutrient cycling]
Differential Interactions of Serum and Bronchoalveolar Lavage Fluid Complement Proteins with Conidia of Airborne Fungal Pathogen Aspergillus fumigatus

Even though both cellular and humoral immunities contribute to host defense, the role played by humoral immunity against the airborne opportunistic fungal pathogen Aspergillus fumigatus has been underexplored. In this study, we aimed at deciphering the role of the complement system, the major humoral immune component, against A. fumigatus. Mass spectrometry analysis of the proteins extracted from A. fumigatus conidial (asexual spores and infective propagules) surfaces opsonized with human serum indicated that C3 is the major complement protein involved. ABSTRACT Even though both cellular and humoral immunities contribute to host defense, the role played by humoral immunity against the airborne opportunistic fungal pathogen Aspergillus fumigatus has been underexplored. In this study, we aimed at deciphering the role of the complement system, the major humoral immune component, against A. fumigatus. Mass spectrometry analysis of the proteins extracted from A. fumigatus conidial (asexual spores and infective propagules) surfaces opsonized with human serum indicated that C3 is the major complement protein involved. Flow cytometry and immunolabeling assays further confirmed C3b (activated C3) deposition on the conidial surfaces. Assays using cell wall components of conidia indicated that the hydrophobin RodAp, β-(1,3)-glucan (BG) and galactomannan (GM) could efficiently activate C3. Using complement component-depleted sera, we showed that while RodAp activates C3 by the alternative pathway, BG and GM partially follow the classical and lectin pathways, respectively. Opsonization facilitated conidial aggregation and phagocytosis, and complement receptor (CR3 and CR4) blockage on phagocytes significantly inhibited phagocytosis, indicating that the complement system exerts a protective role against conidia by opsonizing them and facilitating their phagocytosis mainly through complement receptors. Conidial opsonization with human bronchoalveolar lavage fluid (BALF) confirmed C3 to be the major complement protein interacting with conidia. Nevertheless, complement C2 and mannose-binding lectin (MBL), the classical and lectin pathway components, respectively, were not identified, indicating that BALF activates the alternative pathway on the conidial surface. Moreover, the cytokine profiles were different upon stimulation of phagocytes with serum- and BALF-opsonized conidia, highlighting the importance of studying interaction of conidia with complement proteins in their biological niche.
Antibiotic Stewardship in Staphylococcus aureus Bloodstream Infection Treatment—Analysis Based on 29,747 Patients from One Hospital

Some of the most serious healthcare-associated infections (HAI) are highly deadly bloodstream infections (BSIs) caused by Staphylococcus aureus. The aim of the study was to analyse compliance of treatment practice with clinical guidelines in patients with S. aureus BSIs. The study was conducted at the Sosnowiec Hospital, Poland in 2019. During the study, 29,747 patients were hospitalized and 41 S. aureus BSIs (only HAIs) episodes were observed. According to local clinical practice guidelines, each case of BSI required blood cultures, echocardiography and control culture after the implementation of the targeted therapy. Incidence rate of S. aureus BSI was 0.8/1000 admissions; the greatest department admission rates were in the ICU (19.3/1000 admissions) and in the Nephrology Department (8.7/1000 admissions). Only 2 patients were treated following the protocol (4.8%); the most common errors were the use of an inappropriate drug or incorrect duration of antibiotic treatment. No patient underwent echocardiography, and control cultures were performed in 70% of cases. The case fatality rate was 7.3%. A satisfactorily low case fatality rate was found despite the poor antibiotic stewardship. Lack of discipline concerning antibiotic use can strongly impact the observed high drug resistance in HAIs and high Clostridioides difficile incidence rate in the studied hospital.
Machine (cid:1) Learning (cid:1) Explainability in (cid:1) Breast (cid:1) Cancer (cid:1) Survival

(cid:1) Machine (cid:1) Learning (cid:1) (ML) (cid:1) can (cid:1) improve (cid:1) the (cid:1) diagnosis, (cid:1) treatment (cid:1) decisions, (cid:1) and (cid:1) understanding (cid:1) of (cid:1) cancer. (cid:1) However, (cid:1) the (cid:1) low (cid:1) explainability (cid:1) of (cid:1)
Channel Defect Profiling and Passivation for ZnO Thin-Film Transistors

The electrical characteristics of Zinc oxide (ZnO) thin-film transistors are analyzed to apprehend the effects of oxygen vacancies after vacuum treatment. The energy level of the oxygen vacancies was found to be located near the conduction band of ZnO, which contributed to the increase in drain current (ID) via trap-assisted tunneling when the gate voltage (VG) is lower than the specific voltage associated with the trap level. The oxygen vacancies were successfully passivated after the annealing of ZnO in oxygen ambient. We determined that the trap-induced Schottky barrier lowering reduced a drain barrier when the drain was subjected to negative bias stress. Consequentially, the field effect mobility increased from 8.5 m2 V−1·s−1 to 8.9 m2 V−1·s−1 and on-current increased by ~13%.
Changes in Bone Mineral Density During and After Lactation in Ugandan Women With HIV on Tenofovir‐Based Antiretroviral Therapy

Antiretroviral therapy (ART) in people living with human immunodeficiency virus (HIV) is associated with bone loss, but data are limited in lactation, when physiological bone mineral mobilization is occurring. This research charted changes in areal bone mineral density (aBMD) during and after lactation in Ugandan women with HIV (WWH) initiated onto ART in pregnancy, compared to women without HIV (REF). One‐hundred WWH on tenofovir‐based ART and 100 REF were enrolled in pregnancy. Lumbar spine (LS), total hip (TH), and whole‐body‐less‐head (WBLH) aBMD were measured by dual‐energy X‐ray absorptiometry (DXA) at 2, 14, and 26 weeks of lactation, and at 3 months postlactation. The primary outcome was the difference between groups in mean percent change in LS aBMD between 2 and 14 weeks. Statistical analysis was performed in hierarchical repeated measures ANOVA models that corrected for multiple testing. Median age was 23.4 (IQR, 21.0 to 26.8) years. WWH had lower body weight. aBMD decreased in both groups during lactation, but WWH had greater decreases at TH (2‐to‐26 weeks: WWH [n = 63] −5.9% [95% CI, −6.4 to −5.4] versus REF [n = 64] −4.3% [95% CI, −4.8 to −3.8]; group*time point interaction p = .008). Decreases in LS aBMD were similar in WWH and REF (2‐to‐26 weeks: −2.0% [95% CI, −2.5 to −1.5]), although there was a tendency toward a smaller decrease in WWH between 2 and 14 weeks (WWH [n = 77] −1.8% [95% CI, −2.2 to −1.4] versus REF [n = 69] −2.9% [95% CI, −3.3 to −2.5]; group*time point interaction p = .08). Postlactation, LS aBMD was higher relative to week 2 in both groups. TH and WBLH aBMD did not return to week 2 values in WWH but did in REF (TH postlactation versus week 2: WWH [n = 61] −3.1% [95% CI, −3.6 to −2.6]; REF [n = 29] +0.1% [95% CI, −0.9 to +1.1]). These data show accentuated bone loss during lactation and only partial skeletal recovery by 3 months postlactation in Ugandan WWH on tenofovir‐based ART. Studies are ongoing to understand longer‐term consequences for bone health. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.
Potential Years of Life Lost Due to COVID-19 in the United States, Italy, and Germany: An Old Formula with Newer Ideas

Today, the world is facing the challenge of a major pandemic due to COVID-19, which has caused more than 6.1 million cases of infection and nearly 370,000 deaths so far. Most of the deaths from the disease are clustered in the older population, but the young and children are not spared. In this context, there is a critical need to revisit the formula for calculating potential years of life lost (PYLL). Data on age-specific deaths due to COVID-19 in three countries, including the United States (US), Italy, and Germany, were evaluated. New York State, as a significant outlier within the US, was also included. PYLLs in the US were five times as high as those of Italy. Compared with Germany, PYLLs in Italy were 4 times higher, and the rates in the US were 23, 25, and 18 times higher when using upper age limits of 70, 75, and 80, respectively. Standardized PYLLs in New York were 2 times as high as the rates in Italy, and 7 to 9 times as high as PYLLs in Germany. The revised formula of PYLL, using an upper limit of age 80, is recommended to accurately measure premature deaths due to a major disastrous disease such as COVID-19.
Research article Transcriptional regulation of gene expression clusters in motor neurons following spinal cord injury

Background: Spinal cord injury leads to neurological dysfunctions affecting the motor, sensory as well as the autonomic systems. Increased excitability of motor neurons has been implicated in injury-induced spasticity, where the reappearance of self-sustained plateau potentials in the absence of modulatory inputs from the brain correlates with the development of spasticity. Results: Here we examine the dynamic transcriptional response of motor neurons to spinal cord injury as it evolves over time to unravel common gene expression patterns and their underlying regulatory mechanisms. For this we use a rat-tail-model with complete spinal cord transection causing injury-induced spasticity, where gene expression profiles are obtained from labeled motor neurons extracted with laser microdissection 0, 2, 7, 21 and 60 days post injury. Consensus clustering identifies 12 gene clusters with distinct time expression profiles. Analysis of these gene clusters identifies early immunological/inflammatory and late developmental responses as well as a regulation of genes relating to neuron excitability that support the development of motor neuron hyper-excitability and the reappearance of plateau potentials in the late phase of the injury response. Transcription factor motif analysis identifies differentially expressed transcription factors involved in the regulation of each gene cluster, shaping the expression of the identified biological processes and their associated genes underlying the changes in motor neuron excitability. Conclusions: This analysis provides important clues to the underlying mechanisms of transcriptional regulation responsible for the increased excitability observed in motor neurons in the late chronic phase of spinal cord injury suggesting alternative targets for treatment of spinal cord injury. Several transcription factors were identified as potential regulators of gene clusters containing elements related to motor neuron hyper-excitability, the manipulation of which potentially could be used to alter the transcriptional response to prevent the motor neurons from entering a state of hyper-excitability.
The effect of fire frequency on the sclerophyll vegetation of the West Head, New South Wales

The effect of fire frequency on the relative abundance of obligate-seeders and vegetative-regenerators was studied in 15 pairs of sites on the West Head, NSW. Each site pair consisted of a site which had been burnt frequently over the past 20 years and a nearby site which had been burnt less frequently. The data were collected in two phases. First, the relative abundance of the two overall groups of vegetative-regenerators and obligate-seeders was recorded by measuring the projective cover of live foliage. The presence or absence of particular species was then measured. For all the site pairs the projective cover of live foliage of obligate-seeders was dramatically less in the frequently burnt sites. Some obligate-seeder shrub species were absent from frequently burnt sites and the vegetation structure was simplified. In 11 of the 15 site pairs there was an increase in the projective cover of live foliage of vegetative-regenerators in the frequently burnt sites, while in the remaining four site pairs there were no significant differences between the infrequently and frequently burnt sites. Overall, the increases in the relative abundance of vegetative-regenerators made by high fire frequencies were not as large as the decreases in the relative abundance of obligate-seeders.