Miracle-dz/UniFAR-FTUs huggingface dataset:
Fear of cancer recurrence, anxiety and depressive symptoms in adolescent and young adult cancer patients

Background: Previous studies have indicated that younger age is consistently associated with high levels of fear of cancer recurrence (FCR), anxiety and depression. However, the associations among these variables in adolescent and young adult (AYA) cancer patients are not clear. This study explores the prevalence and correlates of FCR, anxiety and depressive symptoms in Chinese AYA cancer population. Methods: This is a cross-sectional study that includes 249 patients aged between 15 and 39 yrs at the time of cancer diagnosis. Patient’s sociodemographic, clinical as well as psychological characteristics were collected by an information sheet, the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), General Anxiety Disorder Questionnaire (GAD-7) and Patient Health Questionnaire (PHQ-9). Descriptive statistics and multivariate analyses were conducted. Results: Eighty-nine (35.74%) patients experienced dysfunctional level of FCR, eighty-two (32.93%) patients experienced anxiety symptoms and ninety-six (38.55%) reported depressive symptoms. In multivariate analyses, being single, pessimistic, having more concurrent stressful life events and physical comorbidity were independently associated with higher FCR, anxiety and depressive symptoms. Patients who were not engaging in radiotherapy were more likely to report higher anxiety level. Conclusion: FCR, anxiety and depressive symptoms are frequently reported problems among AYA cancer patients. Age-appropriate and flexible psychological interventions are needed for this high-risk population.
RNA splicing in the heart

We recently provided evidence that alternative splicing underlies the formation of circular RNAs (circRNA) arising from the Titin (TTN) gene. Since it is still unclear how circRNAs are generally formed, we hypothesized that alternative splicing, and in particular exon skipping, is a major driver of circRNA production. We performed RNA sequencing on human and mouse hearts, mapped alternative splicing events and overlaid these with expressed circRNAs at exon level resolution. In addition, we performed RNA sequencing on hearts of Rbm20 KO mice to address how important Rbm20-mediated alternative splicing is in the production of cardiac circRNAs. In human and mouse hearts, we show that cardiac circRNAs are mostly (~90%) produced from constitutive exons and less (~10%) from alternatively spliced exons. In Rbm20 KO hearts, we identified 38 differentially expressed circRNAs of which 12 were produced from the Ttn gene. Even though Ttn appeared the most prominent target of Rbm20 for circularization, we also detected Rbm20-dependent circRNAs arising from other genes including Fan1, Stk39 and Bcl2l13. Interestingly, only Ttn circRNAs seemed to arise from Rbm20-mediated skipped exons. In conclusion, cardiac circRNAs are mostly derived from constitutive exons, suggesting that these circRNAs are generated at the expense of their linear counterpart and that circRNA production impacts the accumulation of the linear mRNA.
An experimental study of the effect of water and chlorine on plagioclase nucleation and growth in mafic magmas: application to mafic pegmatites

Abstract. In this study, the effects of H2O and Cl on the grain size and nucleation delay of plagioclase in basaltic magma were investigated using dynamic and equilibrium experiments at 1150 ∘C, 300 MPa, and oxygen fugacity between FMQ − 1.65 and FMQ + 0.05 (fayalite–magnetite–quartz). Each experiment consisted of five samples of basaltic composition (from the Hamn intrusion in Northern Norway) containing varying amounts of H2O (up to 2 wt %) and Cl (up to 1 wt %). The equilibrium experiments were used as a reference frame for the phase assemblage, geochemical composition, and liquidus temperatures and were compared to thermodynamic models using MELTS software. Experimental phase abundances and plagioclase compositions are in good agreement with the predictions of MELTS. The dynamic experiments were initially heated above the liquidus temperature to destroy crystal nuclei and then kept at 1150 ∘C for 100, 250, or 1800 min. These experiments show that as the concentration of H2O in the melt increases, plagioclase nucleation is delayed, plagioclase abundance decreases, but its size increases. Therefore, the addition of H2O seems to favor plagioclase growth at the expense of nucleation. Thermodynamic and kinetic calculations corroborate an increase in the nucleation delay of plagioclase with increasing H2O content dissolved in the melt, suggesting that H2O decreases the undercooling of the silicate melt. The addition of Cl also seems to delay plagioclase nucleation, although this is not supported by kinetic calculations. Increasing the Cl content decreases plagioclase abundance but does not significantly affect its size. The homogeneous pegmatitic pockets of the mafic–ultramafic Hamn intrusion exhibit several petrological and geochemical features, suggesting that H2O and Cl enrichment in the silicate melt was the origin of the pegmatitic texture. The experimental results presented here indicate that H2O, rather than Cl, may have played an important role in the formation of the pegmatitic texture.
Recent developments in the ﬁ eld of bending rigidity measurements on membranes

Emphasis isplaced on techniquesbasedon theuse ofgiant unilamellar vesicles. We summarizethe effect on the bending rigidity of membranes as a function of membrane composition, presence of various inclusions in the bilayer and molecules and ions in the bathing solutions. Examples for the impact of temperature, cholesterol, some peptides and proteins, sugars and salts are provided and the literature data are discussed critically. Future directions, open questions and possible developments in this research ﬁ eld are also included.
Progress on Cholesterol Metabolism in Osteoarthritis

: Studies on risk factors of Osteoarthritis (OA) suggest that patients with OA are associated with abnormal lipid metabolism, and hyperlipidemia may also be a risk factor for OA. In this paper, we review the crucial role of metabolic syndrome in the pathology of Osteoarthritis, investigate the relationship between osteoarthritis and TC levels, clarify the association between cholesterol levels and chondrocytes, oxidative stress, and the therapeutic means to alleviate Osteoarthritis by regulating cholesterol levels.
cali-Genetic analysis of groups of mid-infrared predicted fatty acids in milk

The objective of this study was to investigate genetic variability of mid-infrared predicted fatty acid groups in Canadian Holstein cattle. Genetic parameters were estimated for 5 groups of fatty acids: short-chain (4 to 10 carbons), medium-chain (11 to 16 carbons), long-chain (17 to 22 carbons), saturated, and unsaturated fatty acids. The data set included 49,127 test-day records from 10,029 first-lactation Holstein cows in 810 herds. The random regression animal test-day model included days in milk, herd-test date, and age-season of calving (polynomial regression) as fixed effects, herd-year of calving, animal additive genetic effect, and permanent environment effects as random polynomial regressions, and random residual effect. Legendre polynomials of the third degree were selected for the fixed regression for age-season of calving effect and Legendre polynomials of the fourth degree were selected for the random regression for animal additive genetic, permanent environment, and herd-year effect. The average daily heritability over the lactation for the medium-chain fatty acid group (0.32) was higher than for the short-chain (0.24) and long-chain (0.23) fatty acid groups. The average daily heritability for the saturated fatty acid group (0.33) was greater than for the unsaturated fatty acid group (0.21). Estimated average daily genetic correlations were positive among all fatty acid groups and ranged from moderate to high (0.63–0.96). The ge-netic correlations illustrated similarities and differences in their origin and the makeup of the groupings based on chain length and saturation. These results provide evidence for the existence of genetic variation in mid-infrared predicted fatty acid groups, and the possibility of improving milk fatty acid profile through genetic selection in Canadian dairy cattle.
Stem Cell Applications in Military Medicine with an Emphasis on Combat Medicine

Military medicine is a field of medicine that pertains to the needs and treatment of soldiers and military personnel. Although there is a great deal of overlap between civilian medicine and military medicine, military personnel are likely to experience more nuanced forms of injury than their civilian counterparts and thus require novel treatment methods that are unique to the combat environment. Within battlefield environments, there are an increasing number of traumatic injuries that result from explosive devices, high-caliber projectile weapons, and an array of devastating chemical weapons. Many of the injuries are widespread and affect multiple organ systems. Current treatment methods incorporate alleviation of pain and symptoms, life-saving surgeries to prevent further damage and repair present ones, as well as a variety of prosthetic devices and other assistive equipment. Although there is currently no treatment method that can serve to restore and regenerate damaged tissue resulting from the traumatic injuries currently, new avenues of medicine are being worked on. Potential applications of stem cells within military medicine will be reviewed as well as an exploration of the current state of stem cell research on regenerative medicine. Specifically, tissue regenerative technologies of various organ systems and the storage of these tissues will be explored. Commentary will also be provided specifically to field medicine within a combat environment in which novel new protocols may be implemented with a stem cell application.
Autologous Fat Transfer for Gluteal Augmentation: A Meta-Autologous Fat Transfer for Gluteal Augmentation: A Meta-Analysis Study Analysis Study

Background : In 1969, Bartels et al. presented the initial description of gluteal augmentation using a breast Cronin prosthesis to treat buttock asymmetry. In recent decades, gluteal fat grafting has seen one of the fastest-growing rates of any cosmetic surgery technique. Objectives : Analyze the published techniques of autologous fat transfer for Buttock augmentation (BBL), and compare different protocols to identify which technique is better in safety and effectiveness over the last 5 years, with demonstration of clinical cases. Subjects and methods : This research was carried out by the Plastic Surgery and Burn Unit of the Al-Azhar University School of Medicine. The latest version of the PRISMA statement was adhered to, and both checklist and ﬂ ow diagram are reported. This study attained all global research published by national and international authors up to the moment, which utilized the Autologous Fat Grafting for Gluteal Augmentation. Result : From the initial pool of 800 items found, 150 were eliminated due to duplication. After examining the titles and abstracts of 200 papers, we made our ﬁ nal selections. We read all 59 papers in their entirety and checked their cited works for further resources. Fifteen articles were selected because they ful ﬁ lled our inclusion criteria. Conclusion : In our meta-analysis, the technique proved its ef ﬁ cacy and safety as the overall satisfaction is excellent and most complications were minors with no mortality reported.
Plasma metabolomic analysis of human hepatocellular carcinoma before and after transcatheter arterial chemoembolization

Introduction: Hepatocellular carcinoma (HCC) is the fourth most prevalent cancer in China. Transcatheter arterial chemoembolization (TACE) is a common interventional therapy for HCC. In this study, we aimed to explore specific metabolites that can accurately predict prognosis after TACE in patients with HCC. Methods: Patients with HCC and healthy volunteers (n = 20 each) were recruited to our study; plasma samples were collected from patients before and after TACE and from healthy volunteers. Plasma samples were subjected to untargeted ultra-high performance liquid chromatography-high resolution mass spectrometry metabolomics analysis, to identify metabolites significantly associated with the prognosis of patients with HCC after TACE. Results: Orthogonal filtered partial least squares discriminant analysis confirmed significant separation of the pre-TACE, post-TACE, and healthy groups, and 34 differential metabolites were identified between the pre-TACE and post-TACE groups. KEGG analysis revealed that phenylalanine, tyrosine, and tryptophan biosynthesis pathways and the phenylalanine metabolism pathway were potentially altered in HCC genesis and during TACE. Phenylalanine and tyrosine are involved in both pathways and were increased in the pre-TACE group relative to controls, with phenylalanine further increased in the post-TACE group. Receiver operating characteristic (ROC) curve analysis indicated that PC 36:4|PC 18:2_18:2 (area under the ROC curve (AUC) = 0.798) is a potential marker for assessment of prognosis in patients with HCC after TACE. Moreover, ROC curve analysis indicated that palmitoylcarnitine (AUC = 1) is a marker with potential value for HCC diagnosis. Conclusions: Limited studies had been conducted on the detection of metabolites in the plasma of HCC patients before and after TACE. PC 36:4|PC 18:2_18:2 is a potential marker for evaluation of the therapeutic effects of TACE. This finding may be beneficial for the treatment of patients with HCC after TACE.
Ef ﬁ cacy and safety of tabalumab, an anti-BAFF monoclonal antibody, in patients with moderate-to-severe rheumatoid arthritis and inadequate response to TNF inhibitors: results of a randomised, double-blind, placebo-controlled, phase 3 study

Background: Tabalumab is a human monoclonal antibody that neutralises B-cell activating factor. Objectives: To evaluate tabalumab efficacy and safety in patients with rheumatoid arthritis (RA). Methods: This phase 3, randomised, double-blind, placebo-controlled study evaluated 456 patients with active RA after 24-week treatment with subcutaneous tabalumab (120 mg every 4 weeks (120/Q4W) or 90 mg every 2 weeks (90/Q2W)) versus placebo, with loading doses (240 or 180 mg) at week 0. Patients were allowed background disease-modifying antirheumatic drugs and previously discontinued ≥ 1 tumour necrosis factor α inhibitors for lack of efficacy/ intolerance. Primary end point was American College of Rheumatology 20% (ACR20) response at 24 weeks. This study was terminated early due to futility. Results: Most patients had moderate-to-high baseline disease activity. There was no significant difference in week 24 ACR20 responses between 120/Q4W, 90/ Q2W, and placebo (17.6%, 24.3%, 20%) per non-responder imputation analysis. Mean percent changes in CD20+ B-cell count ( − 10.8%, − 9.6%, +10.9%) demonstrated expected pharmacodynamic effects. Treatment-emergent adverse events (AEs) were similar (59.5%, 51.7%, 52.6%), as were AE discontinuations (2.6%, 2.7%, 2.6%), serious AEs (4.6%, 4.1%, 3.9%), serious infectious events (1.3%, 0, 0) and events of interest: infections (23.5%, 25.9%, 24%), injection site reactions (13.1%, 25.8%, 11%) and allergy/ hypersensitivity (3.9%, 4.1%, 3.9%) reports. Incidence of treatment-emergent antidrug antibodies was similar to placebo (3.9%, 4.8%, 3.9%). No deaths or new/ unexpected safety findings were reported. Conclusions: Tabalumab did not demonstrate clinical efficacy in patients with RA in this phase 3 study, despite evidence of biological activity. There were no notable differences in safety parameters between tabalumab treatment groups and placebo. Trial registration
The Influence of Quality of Work Life on Organizational Commitment Through Job Satisfaction Among Employees of Regional Public Company X

This research was conducted with the aim of examining the influence exerted by quality of work life on organizational commitment through job satisfaction. The research object is located in Regional Public Company X with 89 permanent employees as a result of sample calculation through the use of proportional random sampling method. Distribution of questionnaires by online (google forms) and self administered questionnaire. Descriptive analysis techniques and Partial Least Square Structural Equation Model (SEM-PLS) were applied to test respondent data. The test results interpret that there is a significant and positive unidirectional influence of quality of work life on organizational commitment and job satisfaction. Likewise, there is also a positive and significant finding from job satisfaction to organizational commitment. Then, the indirect effect of quality of work life on organizational commitment through job satisfaction is positive but not significant.
Landlord and Tenant: Housing the Poor in Urban Mexico

Introduction 1. Research Strategy and a Brief Guide to Mexico 2. Residential Tenure in Urban Mexico Since 1940 3. Mexican Housing Policy 4. Urban Development and the Housing Market in Guadalajara and Puebla 5. Residential Tenure : Choice or Constraint 6. Landlords and the Economics of Landlordism 7. Landlord-Tenant Relations 8. The Future of Renting: Policy Options Notes Bibliography Index
Journal of Financial Therapy Journal of Financial Therapy

Women who earn more than their male spouses, in a heterosexual relationship, are a growing underrepresented group. Some female breadwinners feel shame related to the reversal of traditional gender roles. These feelings of shame can interfere with the financial planning process. Five interventions are provided as examples of how financial planners, financial therapists, or financial counselors and other financial professionals can help female breadwinners with shame issues. Whether a planner uses one of these interventions, some other intervention, or no intervention at all will depend on their training and level of competence. Using an intervention can help a female breadwinner deal with shame and progress in the financial planning process.
/ Die ideologischen Grundlagen von universeller und exkludierender Solidarität in

Solidarity is a term and concept many appeal to, especially during crises. It also enjoys a long tradition within social sciences but nevertheless remains a rather ambiguous term with many open questions attached. Based on theoretical literature, this article introduces a multidimensional empirical concept of solidarity by combining opinions regarding global, institutional, group-oriented, and supportive dimensions of solidarity, or a lack thereof. This allows for differentiation between two publicly and politically discussed and contested types of solidarity: universal and exclusive solidarity. The article then further addresses what influences the Austrian (survey) population’s preferences regarding these types of solidarities, with a focus on ideologies. This is empirically tested via survey data and multiple linear regression models. This approach allows for closing an existing gap between the theoretical and empirical literature and for more thoroughly examining the relation between solidarity and the perception of groupings and belongings. The latter is necessary to contrast the different types of solidarity.
Organizational Behavior and Human Decision Processes

Across six studies, we find that both incidental anger and integral anger reduce perspective-taking. In Study 1, participants who felt incidental anger were less likely to take others’ perspectives than those who felt neutral emotion. In Study 2, we demonstrate that arousal mediates the relationship between anger and diminished perspective-taking. In Studies 3 and 4, we show that anger reduces perspective-taking compared to neutral emotion, sadness, and disgust. In Study 5, we find that integral anger impairs perspective-taking compared to neutral emotion. In Study 6, prompting individuals to correctly attribute their feelings of incidental anger moderates the relationship between anger and perspective-taking. Taken together, across different anger in-ductions and perspective taking measures, we identify a robust relationship between anger and diminished perspective-taking. Our findings have particularly important implications for conflict, which is often characterized by feelings of anger and exacerbated by poor perspective-taking.
Physico-Chemical Properties of Toilet Soaps Prepared From Coconut ( Cocos nucifera L.) OIL, MELON ( Cucumeropsis mannii ) Seed Oil and the Blends of The Two

High yield of oil from melon seed and its relatively low cost suggests its usefulness in soap production. This study investigated the physico-chemical properties of soap produced from coconut oil, melon seed oil and a blend of the two. The soaps were produced using the hot process method. Each of the oil was heated to 70 o C and saponified with potassium hydroxide solution in line with its lye factor. Sodium silicate, sodium carbonate and sodium lauryl sulphate were used as additives. The soap was allowed to set for two days and their physico-chemical properties were determined and compared with a popular commercial brand in Nigerian market. The physico-chemical properties of CO soap, MSO soap and the blend respectively were found to be: pH (9.7, 10.1, 10.0); total fatty matter (72.13%, 70.26%, 71.20%); total alkali (0.33%, 0.35%, 0.34%); free caustic alkali (0.11%, 0.10%, 0.10%); moisture content (10.41%, 9.68%, 10.07%); matter insoluble in water (6.78%, 7.02%, 7.0%) and foaming capacity (3.10cm 3 ,2.90cm 3 , 3.20cm 3 ). Each of the soap samples had lower value of matter insoluble in water than a popular brand used as the reference standard but compares favourably with the control in cleansing capacity and other parameters
LEMLEM W ORKING P APER S ERIES The dynamics of automation adoption: Firm-level heterogeneity and aggregate employment effects

We investigate the impact of investment in automation-related goods on adopting and non-adopting firms in the Italian economy during 2011-2019. We integrate datasets on trade activities, firms’, and workers’ characteristics for the population of Italian importing firms and estimate the effects on adopters’ outcomes within a difference-in-differences design exploiting import lumpiness in product categories linked to automation and AI technologies. We find a positive average adoption effect on the adopters’ employment and on the value-added and average wage, whereas sales and productivity increase after an initial drop with a net positive effect five years after adoption. Cru-cially, the employment effect is heterogeneous across firms: a positive scale effect is predominant among small firms, whereas a negative displacement effect is predominant among medium and large firms. We complete the framework with a 5-digit sector-level analysis showing that adopting automation technologies has an overall negative effect on aggregate employment.