Miracle-dz/UniFAR-FTUs huggingface dataset:
Dysphagia following cerebellar stroke: analyzing the contribution of the cerebellum to swallowing function

Swallowing is essential for human health, and the cerebellum is crucial for motor movement regulation. Cerebellar strokes may cause dysphagia, but their exact effects remain unexplored in swallowing function. Therefore, the aim of this study was to analyze the precise clinical characteristics of the oral and pharyngeal phases of swallowing after cerebellar stroke and to critically discuss the cerebellum’s contribution to swallowing. The study involved 34 participants with cerebellar strokes, gathered through convenience sampling. Neurologists diagnosed isolated strokes, and a speech and language pathologist examined swallowing ability using the Mann Assessment of Swallowing Ability. The study found that 52.9% of people experienced dysphagia after a cerebellar stroke. Dysphagia was significantly associated with a higher risk of aspiration. Age was also significantly correlated with dysphagia. No significant correlation was found between swallowing ability and sex. In conclusion, this study suggests isolated cerebellar stroke can adversely affect the motor and non-motor aspects of swallowing and cause severe dysphagia and aspiration risk. Thus, early diagnosis and timely management of dysphagia following a cerebellar stroke can help prevent serious consequences.
The association between subjective anti-doping knowledge and objective knowledge among Japanese university athletes: a cross-sectional study

Introduction This study aimed to assess the association between subjective anti-doping knowledge (subjective ADK) and objective anti-doping knowledge (objective ADK) among Japanese university athletes, framed within the context of the Theory of Planned Behavior (TPB). Methods Eligible participants were 486 university athletes [320 men (65.8%), 166 women; mean age of 18.9 ± 1.0 years]. The participants categorized themselves in terms of the quality of their anti-doping knowledge. This assessment resulted in an independent variable coded as “(1) substantial lack of adequate knowledge,” “(2) some lack of adequate knowledge,” “(3) fair amount of knowledge” or “(4) good amount of knowledge. ” Objective ADK was assessed using the Athlete Learning Program about Health and Anti-Doping (ALPHA) test, a set of questions derived from the ALPHA—a former World Anti-Doping Agency e-learning program. The test comprises 12 questions (four choices each; passing index: ≧10 points or 80% correct answer rate). ANCOVA was conducted using subjective ADK as an independent variable and ALPHA scores as a dependent variable, adjusting for confounding factors (anti-doping experience). Results The ALPHA corrected answer rate across subjective ADK levels for the group were 73.10% for “(1) substantial lack of adequate knowledge,” 71.97% for “(2) some lack of adequate knowledge,” 75.18% for “(3) fair amount of knowledge” and 72.86% for “(4) good amount of knowledge. ” Comparison between different levels of subjective ADK revealed no significant differences in ALPHA score considering the main effects or any of their interactions. Discussion The present results revealed that Japanese university athletes’ subjective ADK did not match their objective ADK. In the context of the TPB, there may be limitations in the perceived behavioral control in anti-doping knowledge. Even if athletes view doping as a wrongful act and have formed attitudes and subjective norms to comply with the rules, the results suggest that errors may occur in the composition of behavioral intentions due to a lack of knowledge. This could lead to the possibility of facing the risk of unintentional anti-doping rule violations. It highlights the need for targeted educational interventions to align subjective ADK of athletes with their objective ADK.
Canine urothelial carcinoma: expression of Periostin in spontaneous canine urothelial carcinoma and its correlation with histological features

The tumor microenvironment is considered one of the main players in cancer development and progression and may influence the behavior of cancer cells. Periostin (POSTN) is an extracellular matrix protein, and its main functions are induction of fibrillogenesis, fibroblastic cell proliferation and migration, enhancing regeneration in normal tissue, and promoting metastasis in case of neoplasia. POSTN has already been studied in humans in several normal tissues, inflammatory processes, and neoplasms, revealing an important role in tumor progression in various types of cancer, such as colon, lung, head and neck, breast, ovarian, and prostate. In these latter, high levels of POSTN are usually associated with a more aggressive tumor behavior, tumor advanced stages, and poor prognosis, while in human bladder urothelial carcinoma (BUC), unlike in most tumors, POSTN expression seems to be downregulated. The expression of this marker has been poorly investigated in veterinary medicine; thus, this study aimed to immunohistochemically investigate the presence and the intensity of POSTN expression in canine BUCs and to determine a possible relationship between POSTN expression and histopathological features such as mitotic count and muscular and vascular invasions. For the present retrospective study, archived samples from 45 canine BUCs and 6 non-neoplastic canine bladders were considered for histological evaluation and immunohistochemical examination for the expression of POSTN. POSTN expression was semi-quantitatively assessed considering both the percentage of the neoplastic stroma positive for POSTN and the intensity of the immunohistochemical labeling. Histologically, 38 out of 45 tumors were papillary and 7 out of 45 were non-papillary. All tumors were infiltrating, being that 21 were muscle-invasive, and a significant correlation between this feature and vascular invasion emerged (P = 0.0001). In normal bladder tissue, as reported in humans, a thick and strongly positive belt of POSTN was visible, and in canine BUCs, stating that the expression is comparable with human benign as well as malignant bladder tissue, a general decrease in POSTN expression was observed except for a strongly labeled ring of POSTN observed around some neoplastic nodules infiltrating the muscle layer. Moreover, POSTN expression and mitotic count were significatively inversely correlated (P = 0.0015). The fact that POSTN protein is less expressed in urothelial carcinomas than in the normal bladder supports what was reported in human BUCs and, together with the negative correlation between mitotic count and protein expression that emerged in the present retrospective study, encourages further prospective follow-up studies to verify the possible role of POSTN in canine BUCs as a prognostic marker, and also as a possible target for the development of future anticancer therapies.
Patients’ Satisfaction With Medication Delivery Pharmacy Services in a Tertiary Hospital in Asir, Saudi Arabia: A Cross-Sectional Study

Background: Pharmaceutical care plays a crucial role in optimizing medication administration and improving patient health outcomes. However, medication adherence remains a challenge, with a significant percentage of patients discontinuing their medications. Value-added services (VASs), such as medication delivery, have been introduced to enhance pharmacy services and medication adherence. Objective: This study aims to evaluate satisfaction with a new medication delivery service at an Armed Forces Hospital outpatient pharmacy in Saudi Arabia and identify factors impacting utilization. Methods: A cross-sectional survey assessed patient satisfaction with a new pharmacy delivery service between January 2023 and March 2023. The target population consisted of adult patients who had used the pharmacy delivery service for at least one month. The survey contained 23 Likert scale questions assessing satisfaction across three domains: delivery process/personnel, medication quality, and pharmacist adherence to best practices. Results: A total of 110 patients responded to the survey, 383 invited patients; the mean age was 51.2 ± 15.3, and most were male 92 (83.6%), married 97 (88.2%), and living in urban areas 63 (57.3%). The overall satisfaction rate was 97 (88.1%), with 67 (60.9%) reporting satisfaction with the medication delivery service. On the delivery process/personnel items, over half strongly agreed that the delivery person called before arriving 59 (53.6%), medications were received on time 58 (51.8%), and the delivery person was polite 64 (58.2%). Most strongly agreed that the service helped with adherence 70 (63.6%) and saved travel costs 72 (65.5%) for medication-quality items. Most also strongly agreed that medications were properly packaged 65 (59.1%) and labeled 71 (64.5%). Regarding pharmacist practices, approximately 56 (50.9%) strongly agreed that the pharmacist provided education materials, inquired about adherence 49 (44.5%), and was respectful 55 (50%). Bivariate analyses found no significant associations between satisfaction and age, gender, residence, education, marital status, income, or disease (all p > 0.05). Satisfaction remained uniformly high across subgroups. Conclusion: The medication delivery service demonstrated excellent patient reception regardless of its characteristics. Overall satisfaction with these services was high. There was no association between sociodemographic characteristics and the level of satisfaction. Continued monitoring and refinement could maximize the quality of pharmaceutical care afforded through innovative models supporting medication adherence.
Structural controls on melt segregation and migration related to the formation of the diapiric Schwerin Fold in the contact aureole of the Bushveld Complex, South Africa

ABSTRACT Partial melting of metapelitic rocks beneath the mafic–ultramafic Rustenburg Layered Suite of the Bushveld Complex in the vicinity of the periclinal Schwerin Fold resulted in a structurally controlled distribution of granitic leucosomes in the upper metamorphic aureole. In the core of the pericline, subvertical structures facilitated the rise of buoyant leucosome through the aureole towards the contact with the Bushveld Complex, with leucosomes accumulating in en-echelon tension gashes. In a subhorizontal syn-metamorphic shear zone to the southeast of the pericline, leucosomes accumulated in subhorizontal dilational structural sites. The kinematics of this shear zone are consistent with slumping of material off the southeastern limb of the rising Schwerin pericline. The syndeformational timing of leucosome emplacement supports a syn-intrusive, density-driven origin for the Schwerin Fold. Modelling of the cooling of the Rustenburg Layered Suite and heating of the floor rocks using a multiple intrusion model indicates that temperatures above the solidus were maintained for >600,000 years up to 300 m from the contact, in agreement with rheological modelling of floor-rock diapirs that indicate growth rates on the order of 8 mm/year for the Schwerin Fold.
Prediction of response to disease-modifying therapy in multiple sclerosis

Background : Multiple sclerosis is an idiopathic in ﬂ ammatory disease of the central nervous system and the second most common cause of disability in young adults. Choosing an effective treatment is crucial to preventing disability. Aim : To identify predictors of disease-modifying therapy (DMT) after 1 year of treatment. Patients and methods : In this retrospective study, 150 patients with con ﬁ rmed diagnosis of relapsing-remittent multiple sclerosis were recruited from the MS Unit at the Neurology Departments from both Ain-Shams University and Cairo University Student Hospital. All of the study population received either interferons or ﬁ ngolimod. Modi ﬁ ed Rio score was used to classify patients to responders and nonresponders. In this study, 128 patients were found responders and 22 were found nonresponders. Results : There was a signi ﬁ cant difference between responders and nonresponders regarding age of the participants. The age was signi ﬁ cantly older in responders compared with nonresponders (mean of 32.37 ± 7.248 vs. 28.55 ± 5.361 years, respectively; P ¼ 0.019). Sex was not a signi ﬁ cant predictor of response to therapy. Regarding the Expended Disability Status Scale at the time of enrollment, it was signi ﬁ cantly higher in nonresponders [median (interquartile range) of 2 (1 e 3)] compared with responders [median (interquartile range) of 1 (0 e 2.5)] ( P ¼ 0.029). Both total number of relapses throughout the course of disease and number of relapses in the last year were signi ﬁ cantly higher in non-responders compared with responders ( P < 0.001). All of the studies MRI parameters including number of T2 lesions, black holes, current enhancing lesions, along with spinal lesions had no signi ﬁ cant correlation with response to therapy. After performing regression analysis, modi ﬁ ed Rio score was a signi ﬁ cant predictor for response to DMT ( P ¼ 0.001). A longer duration of therapy with DMT was predictive for response to DMT ( P ¼ 0.032). Moreover, the compliance to medications ( P ¼ 0.005) and the lower total number of relapses throughout the course of disease ( P ¼ 0.004) were signi ﬁ cant predictors for response to DMT among the study population. Conclusion : In this study, modi ﬁ ed Rio score, a longer duration of therapy with DMT, the compliance to medications, and the lower total number of relapses throughout the course of disease were found to be a signi ﬁ cant predictors for response to DMT among the study population.
Construction of Stratum Simulation Model for Plain Area of Haihe River Basin

Since the late 1960s,rapid economical and social development have been made in the Haihe River Basin for 40 years,by excessive extraction of groundwater and the expense of the hydrogeology environment.The shallow freshwater aquifer will be reduced to die in 2080 according to this mode in the region.The hydrogeologic environment will become more and more deteriorated,which is restricting the regional sustainable economical development.Therefore,protection of groundwater resources for the sustainable development and utilization has become an urgent task at present.Application of modern information technology can analyze large amounts of complex hydrogeologic data and establish the stratum model,which is a very important foundation work to evaluate and manage groundwater resources.However,the depth,lithology and size of the aquifer have a great difference in the different regions due to the vast area of large-scale watershed.Therefore,building stratum model in the large-scale watershed has been domestic problem on groundwater management and research for watershed institutions.This paper described the methods and processes of the established shallow stratum model for the Haihe River Basin by using the software such as ACCESS,SURPARC,GMS.This method is innovative and practical for the reference to large regional stratigraphy structure and groundwater resources management.Finally,this paper made a summary for the process of the model established.
Fracture of Antarctic shelf ice

[1] We have investigated the fracture of Antarctic shelf ice core using two fracture mechanics test methods: the chevron-notched short-rod specimen loaded in tension and the chevron-notched round-bar specimen loaded in three-point bending. These tests have been used to measure the fracture initiation toughness, Kinit, at which crack growth starts, on samples taken through the entire thickness of the Ronne Ice Shelf, from low-density firn through consolidated meteoric ice to basal marine ice. The fracture data are presented together with depth profiles of relevant physical and mechanical properties derived from the test specimens: temperature, density, elastic modulus, and grain size. It is found that the trend in measured fracture toughness closely reflects changes in ice density and elastic modulus. We augment the experimental study by presenting a fracture mechanics analysis of ice shelf surface and basal crevassing which directly incorporates our measurements. For the examined ice shelf profiles, basal crevasses are found to be inherently unstable unless an external restraining force is imposed, which has important implications for overall ice shelf stability. On the other hand, surface crevassing is shown to be innately stable at depth. Our fracture mechanics model is used to predict local ice shelf back stresses in the vicinity of basal crevassing and is validated directly against field observations of crevasse penetration on the Ronne Ice Shelf.
Shark protection plan for the Dutch Caibbean EEZ

Shark populations have steeply declined worldwide due to unsustainable overexploitation and in this the Caribbean region is no exception. Since the 1990s many initiatives have been developed to protect the most threatened species. Sharks play an important ecological role in tropical marine ecosystems and represent an important economic potential in the context of ecotourism. As the Netherlands has traditionally shown strong international leadership and commitment in biodiversity protection, a key ambition of the new Dutch Caribbean Nature Policy Plan 2013-2017, developed jointly with the Dutch Caribbean islands, is the effective implementation of shark protection.
Toward a comprehensive understanding of eye-level urban greenness: a systematic review

ABSTRACT The provision of urban green spaces has been widely acknowledged to offer numerous benefits to individuals and communities. Recently, there has been a growing recognition of the importance of evaluating urban greenness from a human-centered perspective, partly due to the rapid development of eye-level greenness measurement. To provide a comprehensive overview of measurement approaches and topics related to eye-level urban greenness, we conducted a systematic review of 77 relevant papers. Our review revealed that street view images are the primarily utilized data source to quantify eye-level urban greenness in urban analysis. Additionally, simulated eye-level urban greenness represents a new frontier for the general public and urban planners, offering the potential to acquire universally applicable quantitative greenness data. Our findings further suggest that eye-level urban greenness has been explored across various domains, including physical behavior, public health, urban planning, human perception, and inequity. Such exploration has highlighted a significant association between eye-level urban greenness and individuals and communities. Our review generates new insights on the integration of urban greenness into urban planning and design, encouraging a greater focus on eye-level urban greenness as a critical component of urban environmental quality.
Occupational risk factors for multiple sclerosis: a systematic review with meta-analysis

Objective We decided to conduct the first systematic review with meta-analysis to provide the highest level of up-to-date evidence on the occupational risk factors for Multiple Sclerosis. Methods A systematic, comprehensive literature search was performed in four electronic academic databases. We included any case-control study that enrolled working-age subjects and compared the proportion of MS cases with controls who were not exposed to an occupational risk factor. The primary outcome was the occurrence of MS. The quality assessment was performed with the Critical Appraisal Checklist for Case Control Studies, developed, and validated by the Joanna Briggs Institute. All the selection process was also carried out by two independent and previously trained researchers. Results Overall, the total sample included 19,004 people with MS and 4,164,162 controls. Agricultural workers (OR = 1.44, 95% CI 1.13–1.83), offshore workers (OR = 3.56, 95% CI 2.74–4.61), and hairdressers (OR = 8.25, 95% CI 1.02–66.52) were associated with a higher probability of being diagnosed with MS. In parallel, workers exposed to toxic fumes from oil wells (OR = 16.80, 95% CI 8.33–33.90), low-frequency magnetic fields (OR = 1.71, 95% CI 1.03–2.72), and pesticides (OR = 3.17, 95% CI = 2.53–3.99) also had an increased likelihood of having MS. Conclusion Our study has the potential to influence more assertive public policies. Nevertheless, future studies on how the occupational setting may contribute to the incidence of MS are highly recommended. Systematic review registration The protocol was registered in the international prospective register of systematic reviews (PROSPERO– CRD42023443257).
Undergraduate students’ preference between online test and paper-based test in Sub-Saharan Africa

Abstract Computer-based test has been administered in e-learning environments as part of ICT integration in education. Recently, online test is gaining attention in both regular and distance education institutions, and students’ preference or perception of an online test versus paper-based test is crucial in successful adoption or implementation of either of the test modes by any educational institution. For this reason, this study examined undergraduate students’ computer usage experience as a prerequisite for online test completion, and their perception and preference toward online test as opposed to paper-based test. It also examined how students’ perception of online test differed across sex, program major, and computer usage experiences. The findings would contribute to knowledge on factors for consideration, especially by faculty and instructional designers, in successful adoption of online test in undergraduate programmes. An online questionnaire was used to collect data from 213 undergraduate students at a university in Ghana, and the data were analyzed using median, standard deviation, Mann-Whitney U Test, Kruskal–Wallis Test, and Spearman correlation. The results indicated that students had high level of experience in computer usage, they had positive perception and preference for online test, there was no significant differences in perception of online test between female and male students, and among students of different majors. However, there was a positive correlation between computer use experience of the students and their perception of online test. It was recommended that universities seeking to implement online assessment ensure their students are equipped with adequate skills and experiences in computer usage.
The stability of osumilite in metapelitic granulites

Abstract A petrogenetic grid and related diagrams derived from KFMASH-system experiments demonstrate that osumilite is stable in relatively magnesian bulk rock compositions (XMg > 0.6) at temperatures in excess of 875° C and pressures less than 11 kbar. The experiments, involving the dehydration melting of biotite in synthetic metapelites, were conducted in the range 850–1000° C. Both the mineral assemblages and phase compositions reported from well-documented natural examples of osumilite-bearing rocks are reproduced by the experiments at P-T conditions similar to those previously estimated for these occurrences. Peak metamorphic P-T conditions can be reliably inferred from distinctive osumilite-bearing assemblages identified in the phase diagrams, thereby avoiding the problems of diffusional re-equilibration that often prohibits conventional geothermobarometry from recovering peak conditions. Integration of the experimental data with recent independent experiments, after correcting the latter for an underestimated friction correction, allows extension of the petrogenetic grid to higher temperatures. The extended grid is applied to assess and refine the metamorphic history of the Napier Complex, East Antarctica: the high-P stability limit for osumilite in the Napier Complex is 9–10 kbar, the prograde P-T-t path is not necessarily anticlockwise and isobaric cooling in the Scott and Tula mountains occurred, respectively, at pressures greater and less than reactions in the range 8–9 kbar. The stability range for osumilite predicted by the KFMASH-system petrogenetic grid overlaps many more metamorphic terranes than osumilite is found in. Whilst osumilite is not distinctive in thin section and is prone to retrogression, it is possible that carbon dioxide present in the natural system stabilizes cordierite at the expense of osumilite.