Miracle-dz/UniFAR-FTUs huggingface dataset:
Urban Resilience and Residential Greenery—The Evidence from Poland

Social distancing and movement restrictions associated with COVID-19 have highlighted the role played by easily accessible greenery at one’s own residence, which is of key importance to people’s physical and psychological wellbeing. The main focus of this study is to provide insights into residential green areas in Wrocław, Poland in terms of knowledge, investment, trends and associated issues, as examined from the perspective of the potential to boost urban resilience. Sixty-six representative multi-family construction projects typical of Central European cities were analyzed. The study is divided into three stages: I—pre-construction (selection of locations), II—construction of a housing estate (clearance of vegetation, number of trees planted, use of pro-ecological solutions), and III—post-construction (monitoring of the condition of green areas by means of the Normalized Difference Vegetation Index (NDVI) and data from Sentinel-2 satellites). The results highlighted the insufficient use of pro-ecological solutions (green roofs, fountains or ponds) and shortage of woody plants in residential green areas. Their implementation should be included in any strategies for Wrocław’s transformation toward a sustainable post-pandemic city. Furthermore, the main findings of the study also revealed an imbalance between the amount of vegetation cleared vs. vegetation planted during construction and unequal access to high-quality greenery for local residents. Although some positive trends in spatial planning were observed compared to previous studies, two construction projects were implemented in floodplains. NDVI analyses indicate the poor condition of residential green areas; moreover, the change in NDVI for the period 2015–2020 attests to the poor standards of vegetation maintenance. The results of this study suggest that the potential of residential green areas for boosting urban resilience has not been fully utilized in Wrocław. It is highly recommended to implement monitoring of the condition of green areas by means of NDVI and to introduce detailed provisions on the shaping of green estate areas in the Local Development Plans to enhance Wrocław’s resilience. The main findings being presented expand the directions of methods of monitoring residential areas’ conditions in terms of applied landscape research and boosting urban resilience.
Entrepreneurial team heterogeneity and performance of academic spin-offs: a pre and postfoundation analysis

ABSTRACT The present research identifies the drivers of the growth of academic spin-offs (ASOs). Empirical studies have found few successful cases of ASOs from a firm-level perspective; many companies fail, and others tend to remain small without making a meaningful contribution to local economic development. Consequently, analysing the factors affecting spin-off growth is important to understand their potential benefits for society. A large portion of studies focus on external drivers of ASO growth, while we concentrate on the internal dimension, analysing the effect of the heterogeneity of entrepreneurial teams on the performance of ASOs from a longitudinal perspective. Our paper investigates how ASO entrepreneurial team heterogeneity, both horizontal (cognitive) and vertical (status), and changes in entrepreneurial team heterogeneity between the prefoundation and postfoundation stages affect ASO performance. The results show that vertical heterogeneity in the composition of the prefoundation team is a driver of ASO performance over a shorter time horizon (one year) and more so if the average seniority of academics is low. Horizontal heterogeneity plays a negative moderating role. However, longer-term performance is more influenced by horizontal heterogeneity, implying slower growth after the spin-off foundation. These findings should provide important insights for both managers and Italian policy-makers.
Propagation of avian influenza virus in embryonated ostrich eggs

Influenza A viruses (IAVs) are typically isolated and cultured by successive passages using 9- to 11-day-old embryonated chicken eggs (ECEs) and in 14-day old ECEs for virus mutational studies. Real-time reverse transcription-polymerase chain reaction tests (RT-PCRs) are commonly used for IAV diagnosis, but virus isolation remains invaluable in terms of its high sensitivity, providing viable isolates for further studies and the ability to distinguish between viable and nonviable virus. Efforts at isolating ostrich-origin IAVs from RT-PCR positive specimens using ECEs have often been unsuccessful, raising the possibility of a species bottleneck, whereby ostrich-adapted IAVs may not readily infect and replicate in ECEs, yet the capacity of an ostrich embryo to support the replication of influenza viruses has not been previously demonstrated. This study describes an optimised method for H5 and H7 subtype IAV isolation and propagation in 28-day old embryonated ostrich eggs (EOEs), the biological equivalent of 14-day old ECEs. The viability of EOEs transported from breeding sites could be maximised by pre-incubating the eggs for 12 to 14 days prior to long-distance transportation. This method applied to studies for ostrich-adapted virus isolation and in ovo studies will enable better understanding of the virus-host interaction in ostriches and the emergence of potentially zoonotic diseases.
The Impact of Obesity on the Fitness Performance of School-Aged Children Living in Rural Areas—The West Attica Project

This study aimed to investigate the relationship of body mass index (BMI) with muscle and cardiorespiratory fitness in children living within rural areas (regional unit of West Attica) in Greece. Participants included 399 students (187 boys, 212 girls), ages 8–12 years old, and were evaluated in physical performance tests. The point prevalence of overweight and obesity was 21.39% and 26.20% in boys, and 19.90% and 23.79% in girls. Significant differences were observed in all physical performance tests (handgrip, long jump, shuttle run, trunk flexors, and extensors endurance) between normal weight and obese participants. BMI was positively correlated with handgrip (r = 0.442−0.462, p < 0.001). There was a negative association with long jump (r = −0.206, p < 0.001), 20 m shuttle run (r = −0.394, p < 0.001), trunk flexors (r = −0.403, p < 0.001) and trunk extensors endurance (r = −0.280, p < 0.001). The regression analysis showed that 20–30% of the overall variation for physical performance assessments could be accounted for by BMI, age, and sex. With the exception of the long jump and the endurance of the trunk extensors, BMI alone may explain more than 10% of the outcome of most tests. This study highlights the determinant of BMI on muscle and cardiorespiratory fitness. The management of obesity should begin early in childhood to prevent adult chronic cardiovascular and metabolic diseases.
When it doesn’t get better: A qualitative study of eating disorders, sexual identity, and coming out in sexual minority men

Abstract Introduction This study explores the relationship between sexual identity, coming out, and eating disorders to more fully understand the high rates of eating disorders and body dissatisfaction among sexual minority men. Method A sample of 15 sexual minority men (14 gay, one queer) with a diagnosed eating disorder completed qualitative interviews about their experiences related to their sexual identity, coming out process, and eating disorder. Results Qualitative data analysis based on grounded theory strategies revealed that the majority of participants identified their coming out process as playing a notable role in their body dissatisfaction and eating disorder. After coming out, participants identified unique stressors from within the community of sexual minority men. Participants’ responses were categorized into four theoretical constructs: (1) The Mental Health Toll of the Closet, (2) The Mental Health Toll Out of the Closet, (3) The Mental Health Toll of Assimilating to the Gay Community, and (4) The Mental Health Toll of Gay Dating and Sex. The findings are contextualized based on three relevant theories: minority stress theory, intraminority gay community stress theory, and objectification theory. Conclusion This study found the process of coming out, as well as navigating stressors within the mainstream gay community, are critical to more fully understanding the disparities in eating disorders among sexual minority men.
Are government directors a blessing for actual performance or overvalued by the market? Evidence from China

Abstract The purpose of this study is to deepen our understanding of government directors’ impact on firm performance. This study strives to answer whether government directors have different effects on accounting- and market-based performance. To correct for the endogeneity of government directors caused by self-selection bias, Heckman two-stage model was employed in this study. Using a sample of Chinese publicly listed firms on the Shanghai or Shenzhen Stock Exchanges from 2007 to 2016, the results support our predictions. The results show that government directors are associated with better market-based performance but not finance-based performance, which suggests a discrepancy between the public perspective and the realistic condition. Further, their impact on market-based performance is stronger for firms in high state-monopolized industries, but the results don’t hold for finance-based performance. These findings call for more attention on the actual role played by government directors. Previous studies generally tested the impact of government directors on the overall firm performance without differentiating this construct into distinct, meaningful components that reflect firm performance in various domains or aspects. To the best of our knowledge, this is the first study to analyze and examine the differences in government directors’ effects on accounting- and market-based performance.
Does Human Capital Matter for China’s Green Growth?—Examination Based on Econometric Model and Machine Learning Methods

To tackle the increasingly severe environmental challenges, including climate change, we should pay more attention to green growth (GG), a path to realize sustainability. Human capital (HC) has been considered a crucial driving factor for developing countries to move towards GG, but the impact and mechanisms for emerging economies to achieve GG need to be further discussed. To bridge this gap, this paper investigates the relation between HC and GG in theory and demonstration perspective. It constructs a systematic theoretical framework for their relationship. Then, it uses a data envelopment analysis (DEA) model based on the non-radial direction distance function (NDDF) to measure the GG performance of China’s 281 prefecture level cities from 2011 to 2019. Ultimately, it empirically tests the hypothesis by using econometric model and LightGBM machine learning (ML) algorithm. The empirical results indicate that: (1) There is a U-shaped relationship between China’s HC and GG. Green innovation and industrial upgrading are transmission channels in the process of HC affecting GG. (2) Given other factors affecting GG, HC and economic growth contribute equally to GG (17%), second only to city size (21%). (3) China’s HC’s impact on GG is regionally imbalanced and has city size heterogeneity.
Pharmaceutical Reactivation of Attenuated Apoptotic Pathways Leads to Elimination of Osimertinib Drug-Tolerant Cells

Osimertinib is an EGFR tyrosine kinase inhibitor (TKI) with proven clinical efficacy; however, acquired resistance presents an obstacle to curing EGFR-driven disease. Recent studies have shown that drug-tolerant persister cells (DTP) have a distinct transcriptional profile that may confer specific vulnerabilities. By definition these cells avoid apoptosis, yet little is known about how their survival is regulated. We found that paradoxically, the proapoptotic gene BIM was upregulated in osimertinib DTPs, and cotreatment with BH3 mimetics could trigger DTP cell death. Furthermore, cIAP proteins, antiapoptotic members of the extrinsic pathway, were significantly elevated in DTPs. cIAP antagonists could block DTP formation as an up-front combination, and could eliminate preformed DTPs. Critically, when treated at the time of maximal osimertinib response, cIAP or MCL1 inhibitor treatment could significantly attenuate the regrowth of EGFRm cell line mouse xenografts. Finally, we show that apoptosis can be maximized in cell lines with acquired osimertinib resistance by combining BH3 or SMAC mimetics with agents that target the resistance driver in these models. Taken together, these data suggest novel therapeutic strategies at the point of minimal residual disease or full osimertinib resistance for patients in this critical area of unmet need. Significance: These studies uncover strategies to use targeted agents that activate apoptosis in non–small cell lung cancer cells that survive initial EGFR TKI treatment.
Severe eosinophilia and subsequent dermatologic immune‐related adverse event with squamous cell carcinoma antigen elevation induced by nivolumab and ipilimumab

Immune checkpoint inhibitors (ICIs) for malignant lesions are associated with immune‐related adverse events (irAEs), but reports about severe eosinophilia induced by ICIs are scarce. A 73‐year‐old man with lung squamous cell carcinoma was treated by chemotherapy (carboplatin plus paclitaxel) and ICIs (nivolumab plus ipilimumab). After two cycles of chemotherapy, the ICIs were continued. After 5 months, the eosinophilia, which had exceeded 5000/μl, increasingly deteriorated, and the only detected irAE was a grade 1 rash. Under continuation of the ICIs, although the eosinophilia decreased, a grade 3 rash and severe pruritis subsequently appeared. Squamous cell carcinoma antigen (SCCA) was steeply increased simultaneously. A complete response had been achieved, and oral prednisolone markedly improved the rash, pruritis, and eosinophilia. Clinicians should be aware that precedent severe eosinophilia and subsequent severe irAE could occur in patients treated by nivolumab and ipilimumab, and SCCA elevation could be associated with dermatologic irAE.
Indirect Comparison of 10 kHz Spinal Cord Stimulation (SCS) versus Traditional Low-Frequency SCS for the Treatment of Painful Diabetic Neuropathy: A Systematic Review of Randomized Controlled Trials

Spinal cord stimulation (SCS) is increasingly used to treat painful diabetic neuropathy (PDN). At the time of a recent meta-analysis in this field, data were only available from randomized controlled trials (RCTs) of traditional low-frequency SCS (LF-SCS). However, outcomes from high-frequency 10 kHz SCS treatment are now available. Our study aimed to systematically review the contemporary evidence for SCS in patients with lower limb pain due to PDN and include an indirect comparison of the high- and low-frequency modalities. We searched the PubMed/CENTRAL databases up to 18 August 2022, for peer-reviewed RCTs of SCS that enrolled PDN patients with lower limb pain symptoms. The quality of the evidence was assessed with the Cochrane Risk of Bias tool. Using SCS treatment arm data from the RCTs, we indirectly compared the absolute treatment effect of 10 kHz SCS and LF-SCS. Results are presented in tables and forest plots. This systematic review was reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guidelines. Three RCTs met our eligibility criteria, including the recent 10 kHz SCS RCT (N = 216, 90 implanted) and 2 others that examined LF-SCS (N = 36, 17 implanted; N = 60, 37 implanted). Our analysis of 6-month data found clinically meaningful pain relief with each SCS modality. However, significantly greater pain reduction was identified for 10 kHz SCS over LF-SCS: average pain reduction in the 10 kHz SCS cohort was 73.7% compared with 47.5% in the pooled LF-SCS group (p < 0.0001). In the permanent implant subset, the 50% pain reduction responder rate was 83.3% in the 10 kHz SCS cohort versus 63.0% in the pooled LF-SCS group (p = 0.0072). The overall risk of bias of each included RCT was deemed high, mainly due to the absence of patient blinding. Our analysis indicates that paresthesia-free 10 kHz SCS can provide superior pain relief and responder rate over LF-SCS for managing PDN patients refractory to conventional medical management.
Healthcare resource utilization and quality of life in patients with sarcoidosis‐associated pulmonary hypertension

Abstract A retrospective, observational cohort study was conducted to generate real‐world evidence in adult patients diagnosed with sarcoidosis‐associated pulmonary hypertension (SAPH) at a referral center in England between 2012 and 2019. Data from the referral center electronic medical record database were linked to the National Health Service Hospital Episode Statistics database to collect and analyze patient demographics, clinical characteristics, comorbidities, treatment patterns, health‐related quality of life (HRQoL; assessed using the EmPHasis‐10 questionnaire), healthcare resource utilization (HCRU), costs, and survival. Sixty‐two patients with SAPH were identified. At diagnosis, 84% were in WHO functional class III and presented with significant pulmonary hemodynamic impairment. Cardiovascular and respiratory comorbidities were commonly reported prediagnosis. Median EmPHasis‐10 score at diagnosis was 34, indicative of poor HRQoL. In the 1st year after diagnosis, median (Q1, Q3) per‐patient HCRU was 1 (0, 2) all‐cause inpatient hospitalizations; 3 (2, 4) same‐day hospitalizations; and 9 (6, 11) outpatient consultations. In 24 patients who were hospitalized longer than 1 day in the 1st year after diagnosis, the median duration of hospitalization was 4 days. With a median follow‐up of 1.8 years, the median overall survival was 2.9 years. In this cohort of patients with SAPH, poor HRQoL and high HCRU were observed following diagnosis. To our knowledge, this is the first study to report on HRQoL and HCRU in patients with SAPH. More research is needed on treatment options for this population with high unmet needs.
Benefits of Pulmonary Rehabilitation in Patients with Idiopathic Pulmonary Fibrosis Receiving Antifibrotic Drug Treatment

Background: Although patients with idiopathic pulmonary fibrosis (IPF) often receive treatment with antifibrotic drugs (AFDs) and pulmonary rehabilitation (PR) concurrently, there are no reports on the effect of PR on patients with IPF receiving AFDs. Therefore, we investigated the effect of PR on patients with IPF receiving AFDs. Methods: Eighty-seven eligible patients with IPF (61 male; 72.0 ± 8.1 years; GAP severity stage I/II/III: 26/32/12) were recruited for the study. Patients who completed a 3-month outpatient PR program and those who did not participate were classified into four groups according to use of AFDs: PR group (n = 29), PR+AFD group (n = 11), treatment-free observational group (control group; n = 26), and AFD group (n = 21). There was no significant difference in age, sex, or severity among the groups. Patients were evaluated for physical functions such as 6-min walk distance (6MWD) and muscle strength, dyspnea, and health-related quality of life (HRQOL) at baseline and at 3 months. Results: In the PR group, dyspnea and 6MWD showed significant improvement after the 3-month PR program (p < 0.05 and p < 0.01, respectively). HRQOL was significantly worse at 3 months (p < 0.05) in the AFD group, but not in the other groups. The change in 6MWD from baseline to the 3-month time point was significantly higher in the PR+AFD group than in the AFD groups (p < 0.01). Conclusions: It was suggested that AFD treatment reduced exercise tolerance and HRQOL at 3 months; however, the concurrent use of PR may prevent or mitigate these effects.
A common fixed point theorem for six weakly compatible mappings in complete metric space using rational inequality

The purpose of this paper is to present a common unique fixed-point theorem for six self mappings in complete metric space using weaker condition such as weakly compatible and associated sequence in place of compatible mappings and completeness of the metric space. More over the condition of continuity of any one of mapping is being dropped. Our result generalizes the results of Singh and Chouhan [19], Fisher [4], Lohani and Badshah [13], Sharma, Badshah and Gupta [18].
Catheter Ablation vs. Medical Therapy as First-line for Treatment of Symptomatic Paroxysmal Atrial Fibrillation: A Systematic Review

Introduction: The outcomes of Catheter Ablation (CA) and antiarrhythmic drugs (AAD) as the first-line treatment of paroxysmal Atrial Fibrillation (AF) are unclear. The current systematic review reports the evidence on efficacy outcomes of Radiofrequency Ablation (RFA) versus antiarrhythmic drugs (AAD) among these patients. Methods: Three databases, including PubMed, Cochrane, and Google Scholar, were searched by three independent reviewers to identify relevant randomized control trials (RCTs). Results: A total of 1,145 patients across five studies were assessed in this systematic review. Among these patients, 577 were randomized to receive ablation, and 568 were randomized to receive AAD. The recurrence rate was significantly higher among patients who received AAD at 1-year and 2-year follow-ups. The health-related quality of life (HR-QoL) was significantly better in the patients who received ablation therapy. The incidence of serious adverse events was 14 (6.4%) in the ablation group and 9 (4.3%) in the AAD group. Conclusion: CA seems promising for managing AF in terms of any AF recurrence, hospitalization, and quality of life. There was no increase in side effects compared to AAD.
A Qualitative Study of Pandemic-Induced Telework: Federal Workers Thrive, Working Parents Struggle

This study examines the forced transition to telework during the COVID-19 pandemic using qualitative data from two open surveys administered by the Federal News Network in 2020: in the first two months and, then, 10 months into the pandemic. We provide in-depth analysis of 1,969 open-ended comments from 1,589 federal employees collected seven months apart, telling the story of how they continued performing their responsibilities under a full-time telework schedule. Federal employees perceive the transition to full-time telework during the pandemic had a positive effect on organizational performance, work productivity and work-life balance for most federal employees. An exception is working parents, who faced significant hardships due to the pandemic. Additionally, results show pandemic-induced telework was credited with mixed successes for job satisfaction and social integration, and had not been successful in terms of supervisor support and organizational trust, which puts the success of the social contract theory in these situations in jeopardy. Finally, results suggest that federal employees envision more work will become telework-eligible in the new normal and welcome this shift.