Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation of coronary artery calcium score and carotid artery intima-media thickness with severity of coronary artery disease

Introduction: Coronary artery calcium score (CACS) and carotid artery intima-media thickness (CIMT) are the markers of atherosclerosis. An association between CACS and CIMT with presence of atherosclerotic coronary artery disease (CAD) is well established. However relationship between severity of CAD with CACS and CIMT is less clear. This study aimed to investigate the correlation between severity of CAD assessed by SYNTAX and Gensini scores with CACS and CIMT. Methods: This prospective study was conducted on 351 patients with CAD between June 2015 to December 2016. CACS was obtained using AGATSTON algorithm with 128 slice multidetector computer tomography (MDCT) before conventional coronary angiography (CCA). CIMT was measured by using Philips IE33 Echo machine. The severity of CAD was assessed by SYNTAX score (SS) and Gensini score on CCA. Correlation between severity of CAD with CACS and CIMT was analysed. Results: Mean CACS was 241.5±463.7, and this was positively correlated with over all SS (r=0.417, P <0.0001) and Gensini score (r=0.405, P<0.0001). Mean CIMT was 0.80±0.18 mm and this was also significantly correlated with SS (r=0.450, P<0.0001) and Gensini score (r=0.459,<0.0001). Multivariate analysis showed that CACS was independently associated with diabetes mellitus (β:0.11, P=0.021), SS (β:0.251, P =0.010) and mean CIMT (β:0.128, P =0.028). Receiver-operating characteristic (ROC) curve analysis revealed a cut off CACS of >493 for SS≥33 (high-SS tertile). Conclusion: Our study confirmed a significant correlation between CACS and CIMT with the severity of CAD assessed by SS and Gensini scores. CACS and CIMT may be considered as important noninvasive diagnostic modalities in the assessment of the severity of CAD.
Stormwater Runoff Treatment Using Moringa Oleifera Seed Extract as a Natural Coagulant

Uncontrolled stormwater runoff poses a serious threat to aquatic ecosystems due the presence of harmful pollutants. Effective treatment is important prior to discharge. This study investigated the performance of Moringa oleifera seed extract as a coagulant for the reduction of turbidity, chemical oxygen demand (COD) and total suspended solids (TSS) in stormwater runoff. Stormwater samples were treated with Moringa oleifera seed extract solution at varied coagulant doses (0.5-10%), pH (3-10) and settling durations (20-60 minutes). The samples were analyzed before and after treatment to determine the coagulation efficiencies. There were improvements in stormwater quality, with up to 88%, 70% and 89% reduction in turbidity, COD and TSS levels achieved. Removal efficiencies increased with increase in coagulant dose and settling time. The results of the study indicate that Moringa oleifera can be used in the treatment of stormwater runoff for safe discharge into the aquatic environment.
Load Optimization with Coverage and Connectivity for Wireless Sensor Networks

- The main important function of wireless sensor networks is coverage, sensing and connectivity. Life time of the network is mainly reduced due to the coverage problem imposed by the densely congested sensors in the wireless sensor networks (WSNs) . To overcome such issues, in this paper the proposed novel maximum connected load balancing cover tree(MCLCT) to get entire coverage and base station connectivity of every node by formulating load balanced routing cover trees. For the limited energy of sensor nodes, we are gathering these nodes in to subgroups, which is efficient of monitoring all discrete point of interest (DPOIs). And it is a maximum cover tree problem, which is non-probabilistic complete problem. The MCLCT consists of two strategies: a coverage optimizing recursive heuristic for coverage and the probabilistic load balancing for the determination of the routing path. By using the MCLCT less amount of energy consumption can be done by balancing the load evenly on the nodes. The simulation results show that the energy efficiency and the connectivity of the nodes.
Research trends on the relationship between Microbiota and Gastric Cancer: A Bibliometric Analysis from 2000 to 2019

Background: Hundreds of studies have found that the microbiota contributes to the development of gastric cancer in the past two decades. This study aimed to access the research trends of microbiota and gastric cancer. Materials and Methods: Publications from January 1, 2000 to December 31, 2019 were retrieved from the Web of Science Core Collection database and screened according to inclusion criteria. Different kinds of software, SPSS21.0, HistCite, VOSviewer, CiteSpace, and the online bibliometric analysis platform were used to evaluate and visualize the results. Results: A total of 196 publications were finally identified, and the annual number of publications showed an increasing trend. These publications were from 44 countries and the USA showed its dominant position in publication outputs, H-index, total citations, and international collaborations. The journal of Helicobacter was the most productive journal. Correa P and Peek RM published the most papers, and the most productive institution was Vanderbilt University. The keyword of “Helicobacter pylori” ranked first in research frontiers and appeared earlier, and the keyword of “microbiota” began to appear in the past 3 to 5 years. Conclusion: The annual number of publications would continue to grow. Besides the traditional Helicobacter pylori related researches, future research hotspots will focus on microbiota and its mechanism of action.
Allies, not aliens: increasing the role of local communities in marine protected area implementation

SUMMARY Various management approaches have been proposed to address the alarming depletion of marine coastal resources. Prominent among them are community-based management and the establishment of marine protected areas (MPAs). The overall poor performance of MPAs can be traced to a failure to effectively include local communities in the design and implementation of relevant measures. Recent efforts have incorporated aspects of community-based management into a hybrid form of management, which ideally builds upon existing local management practices. A key challenge lies in the development of appropriate frameworks that allow for the successful participation of local communities in management. A review of studies on MPA design and community-based marine resource management and fieldwork observations provides suggestions on how to address current socioeconomic shortcomings in MPA design and implementation, successfully involving local communities in order to provide a better local basis for effective larger MPA networks. A combination of MPA tools as the formal frame and community-based natural resource management as the adaptive core that recognizes local communities as allies, not aliens, is needed to develop successful conservation approaches.
From Bernstein polynomials to Bernstein copulas

In this paper we review Bernstein and checkerboard copulas for arbitrary dimensions and general grid resolutions in connection with discrete random vectors possessing uniform margins, and point out the relation to tensor product Bernstein operators. We further suggest a pragmatic and effective way to fit the dependence structure of multivariate data to Bernstein copulas via rook copulas, a subclass of checkerboard copulas, which is based on the multivariate empirical distribution.
Integrative Data Analytic Framework to Enhance Cancer Precision Medicine

With the advancement of high-throughput biotechnologies, we increasingly accumulate biomedical data about diseases, especially cancer. There is a need for computational models and methods to sift through, integrate, and extract new knowledge from the diverse available data, to improve the mechanistic understanding of diseases and patient care. To uncover molecular mechanisms and drug indications for specific cancer types, we develop an integrative framework able to harness a wide range of diverse molecular and pan-cancer data. We show that our approach outperforms the competing methods and can identify new associations. Furthermore, it captures the underlying biology predictive of drug response. Through the joint integration of data sources, our framework can also uncover links between cancer types and molecular entities for which no prior knowledge is available. Our new framework is flexible and can be easily reformulated to study any biomedical problem.
Nutrimune and immune defence against pathogens in the gastrointestinal and upper respiratory tracts: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006

Abstract Following an application from H.J. Heinz Supply Chain Europe B.V. submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of the Netherlands, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to Nutrimune and immune defence against pathogens in the gastrointestinal (GI) tract and upper respiratory tract (URT). The food Nutrimune (a pasteurised cow's skim milk fermented with Lactobacillus paracasei CBA L74) which is the subject of the health claim is sufficiently characterised. The Panel considers that immune defence against pathogens in GI tract and URT is a beneficial physiological effect. Two human intervention studies were submitted as being pertinent to the claim, which were evaluated by the Panel in the previous application. One human intervention study from which conclusions could be drawn showed an effect of Nutrimune on immune defence against pathogens in the GI tract and the URT. The post hoc re‐analysis of the two human studies combined does not address the methodological limitations of the second study raised in the previous opinion, i.e. that the study was not planned, designed, randomised and analysed as a multicentre study, and that the large disparity of subjects in the three centres was not duly justified. The results from one animal study could support an effect of Nutrimune on defence against pathogens in the GI tract. No evidence was provided for a plausible mechanism by which Nutrimune could exert the claimed effect in vivo in humans. The Panel concludes that the evidence provided is insufficient to establish a cause and effect relationship between the consumption of Nutrimune and immune defence against pathogens in the GI tract and URT.
The Prevalence of Nondiabetic Renal Diseases in Patients with Diabetes Mellitus in the University Hospital of Ribeirão Preto, São Paulo

Objective To evaluate the prevalence of nondiabetic renal diseases (NDRDs) in renal biopsies of patients with diabetes mellitus (DM) in the University Hospital of Ribeirão Preto, São Paulo. Research Design and Methods. We conducted a retrospective study including kidney biopsies performed in diabetic patients between 1987 and 2013. We evaluated 79 biopsies during this period. The primary variable was the prevalence of NDRD in patients with DM. The secondary variables were the presence of systemic arterial hypertension (SAH), hematuria, time since diagnosis of DM, serum creatinine, and proteinuria levels. The cases were divided into the following groups: isolated diabetic nephropathy (DN—group I), isolated nondiabetic renal diseases (NDRD—group II), associated NDRD/DN (group III), and associated NDRD+NDRD/DN (group IV). Results Most of the patients (58.22%) presented only alterations arising from DN. NDRDs were present in 41.77% of the patients. Membranous glomerulonephritis (30.3%) and IgA nephropathy (24.24%) were the most prevalent NDRDs. We found no differences between female and male patients with NDRD when assessing the secondary variables. A time since diagnosis of five years or less revealed a statistical difference (p = 0.0005) in the comparison between the isolated DN (group I) and the NDRD+NDRD/DN (group IV). The other secondary variables were not significant in the comparison of the groups. Conclusions We concluded that the prevalence of NDRD is 41.77%. Membranous glomerulonephritis was the most prevalent NDRD in our study. We also conclude that the probability of the presence of NDRD with or without concomitant DN is greater for patients who had biopsies with a time since diagnosis of five years or less. A time since diagnosis of ten years or more does not allow the exclusion of the presence of NDRD.
20. Jahrestagung der GMS im Rahmen des Second International FESTEM Symposium on Trace Elements and Minerals in Medicine and Biology, 13. – 15. Mai 2004, in Neuherberg bei München

20. Jahrestagung der GMS im Rahmen des Second International FESTEM Symposium on Trace Elements and Minerals in Medicine and Biology, 13. – 15. Mai 2004, in Neuherberg bei München Die 20. Jahrestagung fand dieses Jahr als Teil des Spurenelementund Mineralstoff Symposiums in Medizin und Biologie der Vereinigung der europäischen Spurenelementgesellschaften (FESTEM) statt. Während dieses 2 1⁄2 tägigen Symposiums wurden Arbeiten von allen beteiligten Gesellschaften präsentiert, wobei vor allem der zweite Tag für Beiträge aus dem Bereich der GMS gedacht war. An diesem Tag fanden auch die
Muscular hypertrophy and growth-promoting effects in juvenile pejerrey (Odontesthes bonariensis) after oral administration of recombinant homologous growth hormone obtained by a highly efficient refolding process

Growth hormone (GH) can be orally administrated to ¢sh in order to increase growth rates. Fish growth is characterized by the hyperplasia and hypertrophy of muscle ¢bre throughout adult life. In this respect, GH could aiect directly and indirectly (by growth and metabolic factors) the development and growth of muscle ¢bres. Recombinant pejerrey GH (r-pjGH) was expressed in Escherichia coli and refolded in a highly e⁄cient batch dilution system, obtaining 0.1g L 1 of hormone without protein precipitation during the refolding procedure. Orally administered hormone to pejerrey produced a 30% increase in mean weight and stimulated liver insulin-like growth factor type I (IGF-I) mRNA expression after 1 month of treatment. Histological analyses showed that muscle growth was generated mainly by hypertrophy of the ¢bres. A higher r-pjGH dose increased muscle ¢bre hypertrophy but somatic growth was negatively aiected probably due to a reduced capacity of generating new ¢bres.
Sentiment, Limited Attention and Mispricing

We examine whether various anomalies can be driven by two common behavioral forces, namely “subjective” sentiment (representing investors’ subjective biased beliefs) and “objective” limited attention (representing investors’ objective cognitive constraints). While sentiment well explains many anomalies that are more speculative on the shortleg, it fails to explain anomalies that are equally speculative on the long and short-leg, including momentum and post-earnings announcement drift. Market-wide attention shifts, proxied by the number of news articles averaged across stocks, significantly attenuate underreaction-driven anomalies, beyond the effect of sentiment. Our findings suggest that an increase in market-wide attention can temporarily reduce the cost of attending to the market and improve price efficiency. JEL classification: G12, G14 ∗Send correspondence to Jun Tu, Lee Kong Chian School of Business, Singapore Management University, Singapore 178899; Telephone: (+65) 6828 0764. E-mail: tujun@smu.edu. sg. We thank Chi Shen Wei, Dashan Huang, and Guofu Zhou for useful comments. The usual disclaimer applies.
Bio-efficacy of Trichoderma viride against the root-knot nematode (Meloidogyne incognita) in tomato plant

In the present studies effectiveness of antagonistic fungi viz. Trichoderma viride were evaluated against Meloidogyne incognita on tomato. The application of T. viride significantly increased shoot weight and decreased root weight of tomato in a dose dependent manner. Doses of 6 gm/kg soil as soil treatment and 9x10 cfu/ml as bare root dip treatment showed maximum increase in shoot weight and decrease in root weight. On the other hand, the antagonistic fungi caused significant reductions in number of galls, egg masses, eggs per egg mass and reproductive factors of M. incognita in a dose dependent manner. The fungi caused the maximum reductions in these parameters at two highest doses of 6 gm/kg soil as soil treatment and 9x10 cfu/ml as bare root dip treatment. It is, therefore, concluded from the present evaluation that the indigenous isolates of T. viride have the potential to control M. incognita as both the treatments viz. soil application and bare root dip treatment.
The Reflection Of The Financial Position Of Enterprises Through Logistical Regression And Natural Logarithm

This paper analyzes the relationship between the size of enterprises and their financial position in front of competitors in the market. So that enterprises to look at their financial position and make better decisions, the finance and accounting department must prepare financial statements and reports (PRF) with reliable data including all items coming from financial transactions. In this research it is explained how logistical regression and natural logarithm in cooperation with all other statistical tests reflect the success or failure of enterprises, in other words their financial position. Finally, the research is argued from empirical findings to 100 enterprises of different activities and sizes, giving a new approach through detailed recommendations for all the studied variables.
Hippocampal Atrophy in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations

This study was conducted to explore hippocampal structural changes and their possible associations with clinical characteristics, emotional status, and treatment regimens in patients with systemic lupus erythematosus (SLE) without major neuropsychiatric manifestations (non-NPSLE). Eighty-five non-NPSLE patients with normal conventional magnetic resonance imaging (MRI) and seventy-seven matched healthy control (HC) subjects were recruited. All participants underwent the standard high-resolution volumetric MRI. The bilateral hippocampal volume (HIPV) and hippocampal density (HIPD) were calculated, respectively, for each participant. We found that the bilateral HIPV and HIPD of the SLE patient group were significantly less than those of the HC group. The bilateral HIPV of female patients were significantly less than those of male patients. The SLE disease activity index (SLEDAI) was negatively correlated with the bilateral HIPV and the right HIPD. Urine protein quantity was negatively correlated with the bilateral HIPV and HIPD. Hydroxychloroquine (HCQ) showed a protective effect on right HIPV. In conclusion, we found that the early hippocampal atrophy could occur before obvious neuropsychiatric manifestations and might be associated with SLE disease activity and organ damages. Early detection and intervention of hippocampal damage might prevent the progression to NPSLE. More studies are needed to fully understand the underlying mechanisms of hippocampal atrophy in SLE.
Prenatal stress, genomic variations and recurrent respiratory tract infections - the FinnBrain Birth Cohort Study

Risk profiles associated with many diseases are formed at a very early stage of development, which occur before birth. Exposure of the fetus to maternal psychological distress during pregnancy may alter fetal biology and thus predispose the fetus to subsequent illnesses such as childhood recurrent respiratory infections. This dissertation is part of the FinnBrain Birth Cohort Study, which recruited 3808 families between years 2012–2015. This prospective cohort-based study followed the symptoms of anxiety and depression in mothers, partnership satisfaction and the occurrence of children’s recurrent respiratory tract infections from the 14th week of pregnancy until the child was two years old. Our aim was to investigate whether there was an association between maternal prenatal psychological distress and the occurrence of the child’s recurrent respiratory tract infections. In a smaller subset of the Cohort, we investigated the association of maternal prenatal psychological distress on cortisol production in 10-week-old children. We also investigated the relationship between genetic susceptibility to respiratory infections and the interaction between genetic susceptibility and maternal prenatal psychological distress. In this study, it was shown that in addition to the previously known risk factors (e.g. the number of siblings, shorter duration of breastfeeding), maternal prenatal psychological distress was associated with an increased risk for recurrent respiratory infections in children. In addition, we found that in children, whose mothers had prenatal psychological distress, had a reduced cortisol response in the stress test depending on if the child had a concomitant rhinovirus infection. Genetic variations in the IFI44L gene, part of the type I interferon pathway, associated with an increased susceptibility to respiratory infections and acute otitis media. Interleukin-6 gene variations were associated with an increased risk for recurrent respiratory infections. There was no interaction between these genetic predispositions and maternal stress during pregnancy, but sex differences were noted. This work provides new preventive strategies for recurrent upper respiratory tract infections in children and offers new insights into the interactions between stress and immune systems.
Characterization of a New Wheat-Aegilops biuncialis 1Mb(1B) Substitution Line with Good Quality-associated HMW Glutenin Subunit

In this study, a new substitution line, 12-5-1, with 42 chromosomes that was derived from BC3F2 descendants of the hybridization between Triticum aestivum cv. CN19 and Aegilops biuncialis was created and reported. The 12-5-1 was immune to both powdery mildew and stripe rust and has stable fertility. Multi-color fluorescence in situ hybridization indicated that 12-5-1 was a substitution line 1Mb(1B). The seed storage protein electrophoresis showed that 12-5-1 presented high molecular weight glutenin subunits (2 + 12) of CN19 and a new subunit designated as M which apparently originated from parent Ae. biuncialis, and absent 7 + 8 subunits. Additionally, the flour quality parameters showed that the protein content, Zeleny sedimentation value, wet gluten content, and grain hardness and mixing time of 12-5-1 were signifiantly higher than those of its parent CN19. Moreover, 5 pairs of the chromosome 1Mb-specifi polymerase chain reaction-based landmark unique gene markers, TNAC1021, TNAC1026, TNAC1041, TNAC1-02.