Miracle-dz/UniFAR-FTUs huggingface dataset:
A Randomized Controlled Pilot Study to Assess Effects of a Daily Pistachio (Pistacia Vera) Afternoon Snack on Next-Meal Energy Intake, Satiety, and Anthropometry in French Women

Including nuts in the diet improves appetite control and does not lead to weight gain. However, for pistachios, evidence from randomized intervention studies is limited and there are no data on the effect of pistachios on satiety. The objective of this study was to assess the effect of daily consumption of pistachios as an afternoon snack on satiety, self-reported energy, self-reported nutrient intake, body weight, and body composition. This randomized controlled pilot study included two parallel groups of 30 healthy French women, in a free-living setting. For four weeks, groups were instructed to consume either 56 g (1318 kJ) of pistachios or 56 g of isoenergetic/equiprotein savory biscuits as an afternoon snack. Evening energy intake, changes in anthropometric measures, and daily intake of energy and selected nutrients were assessed. Visual analogue scales (VAS) were used to rate hunger, fullness, desire to eat, and prospective consumption. Satiety effects were not different between groups, as assessed by evening energy intake or VAS scores. Consuming pistachios or biscuits had no impact on body weight. Thiamin, vitamin B6, copper, and potassium intakes were significantly higher in the pistachio group. Consuming pistachios or biscuits as an afternoon snack resulted in similar post-snack food intake and subjective feelings of satiety. A daily pistachio snack for a month did not affect body weight or composition but it did improve micronutrient intake.
Determinants of Farmers' Participation in Banana Insurance in Chitwan District, Nepal

This study was conducted to identify the factors affecting the adoption of banana insurance in Chitwan district of Nepal. A total of 160 samples (80 insurers and 80 non-insurers of banana producers) were selected randomly to collect primary data. Primary data were collected by conducting household survey using personal interview method in the month of September 2019. The logit model was used to identify the factors affecting the adoption of banana insurance policy among farmers. The result showed that the explanatory variables, area under banana cultivation, membership to cooperatives, and awareness about the agriculture insurance, perception of farmer about the necessity of crop insurance, agriculture extension services, and age of banana orchard were significantly contributing to the adoption of banana insurance policy. It also revealed that organization of awareness program, mobilization of groups and cooperatives were the important tools to promote banana insurance program. The findings would be helpful to make the insurance program more effective and hence increase the adoption of insurance policy and ultimately benefit farmers by enhancing their ability to manage risks in agriculture.
Digital-enabled Design for Manufacture and Assembly (DfMA) in offsite construction: A modularity perspective for the product and process integration

ABSTRACT This study aims to use modularity to impact various facets of Design for Manufacture and Assembly (DfMA) and explore the relationship between product modularity, process modularity, and DfMA within the context of Offsite Construction (OSC). The study fills this gap through an exploratory single case study by identifying perceptual measures of these three concepts. The study shows the alignment between multi-dimensionality of modularity, such as product modularity and process modularity, enhances the capability of DfMA. From a modularity perspective, the reconfiguration of abstraction, information hiding, and interface is an essential strategy to change the traditional design process. This reconfiguration is to adapt to the new scenarios brought by OSC and digital fabrication technologies and the new design tasks associated with these scenarios. This study has theoretical implications for the modular approach to DfMA and practical implications for those who expect digital fabrication techniques in offsite construction.
Quantification of Ventilation and Gas Uptake in Free-Breathing Mice With Hyperpolarized 129Xe MRI

Hyperpolarized 129Xe magnetic resonance imaging is a powerful modality capable of assessing lung structure and function. While it has shown promise as a clinical tool for the longitudinal assessment of lung function, its utility as an investigative tool for animal models of pulmonary diseases is limited by the necessity of invasive intubation and mechanical ventilation procedures. In this paper, we overcame this limitation by developing a gas delivery system and implementing a set of imaging schemes to acquire high-resolution gas- and dissolved-phase images in free-breathing mice. Gradient echo pulse sequences were used to acquire both high- and low-resolution gas-phase images, and regional fractional ventilation was quantified by comparing signal buildup among low-resolution gas-phase images acquired at two flip-angles. Dissolved-phase images were acquired using both ultra-short echo time and chemical shift imaging sequences with discrete sets of flip-angle/repetition time combinations to visualize gas uptake and distribution throughout the body. Spectral features distinct to various anatomical regions were identified in images acquired using the latter sequence and were used for the quantification of gas arrival times for respective compartments.
A Method for Detecting Atmospheric Lagrangian Coherent Structures Using a Single Fixed-Wing Unmanned Aircraft System

The transport of material through the atmosphere is an issue with wide ranging implications for fields as diverse as agriculture, aviation, and human health. Due to the unsteady nature of the atmosphere, predicting how material will be transported via the Earth’s wind field is challenging. Lagrangian diagnostics, such as Lagrangian coherent structures (LCSs), have been used to discover the most significant regions of material collection or dispersion. However, Lagrangian diagnostics can be time-consuming to calculate and often rely on weather forecasts that may not be completely accurate. Recently, Eulerian diagnostics have been developed which can provide indications of LCS and have computational advantages over their Lagrangian counterparts. In this paper, a methodology is developed for estimating local Eulerian diagnostics from wind velocity data measured by a single fixed-wing unmanned aircraft system (UAS) flying in a circular arc. Using a simulation environment, driven by realistic atmospheric velocity data from the North American Mesoscale (NAM) model, it is shown that the Eulerian diagnostic estimates from UAS measurements approximate the true local Eulerian diagnostics and also predict the passage of LCSs. This methodology requires only a single flying UAS, making it easier and more affordable to implement in the field than existing alternatives, such as multiple UASs and Dopler LiDAR measurements. Our method is general enough to be applied to calculate the gradient of any scalar field.
What is it like learning with an enthusiastic teacher? – A survey on university EFL students

Students need effort and motivation to get outstanding scholastic achievements and to keep themselves motivated throughout their educational journey. Some students drop out of school owing to demotivation in class. Others struggle to find excitement or interest in their study. One of the most crucial things in keeping students inspired to learn while they are at school is the teacher. There is a lot of research that has studied the effects of teachers' enthusiasm on students' learning, especially learning motivation, but little has been done on EFL (English as a foreign language) students at university. This study aimed to investigate how EFL students feel in relation to their learning motivation when they learn with an enthusiastic teacher. The participants are 150 EFL students from a university in Ho Chi Minh City, Vietnam. To collect and analyze the data needed for this investigation, the researchers used a quantitative method with a questionnaire employed as a measurement tool. The result has found that student’s positive perceptions exceptionally outweigh negative ones. The study concludes by making some recommendations for better motivating students and for future research.
Pengaruh Leverage, Profitabilitas dan Ukuran Perusahaan Terhadap Konservatisme Akuntansi pada Perusahaan Pertambangan di Indonesia, Malaysia, dan Singapura

Penelitian ini bertujuan untuk menguji pengaruh leverage, profitabilitas, dan ukuran perusahaan terhadap konservatisme akuntansi pada perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia (IDX), Bursa Malaysia, dan Singapore Stock Exchange (SGX) periode 2013 - 2017. Data penelitian ini adalah laporan keuangan dari 23 sampel perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia (IDX), Bursa Malaysia, dan Singapore Stock Exchange (SGX) yaitu 14, 7, dan 2. Penelitian ini menggunakan metode purposive sampling. Metode analisis data yang digunakan untuk menguji hipotesis dalam penelitian ini adalah regresi linier berganda (multiple linear regression) dengan program SPSS. Uji yang digunakan adalah uji statistik deskriptif, uji asumsi klasik dan uji hipotesis. Hasil penelitian menunjukkan bahwa variabel independen berupa leverage, profitabilitas, dan ukuran perusahaan secara simultan berpengaruh terhadap variabel dependen yaitu konservatisme akuntansi. Secara parsial variabel leverage dan ukuran perusahaan tidak berpengaruh signifikan terhadap konservatisme akuntansi, sedangkan variabel profitabilitas berpengaruh signifikan terhadap konservatisme akuntansi.
A Stillborn Multiple Organs’ Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization

Dengue virus (DENV) is an emerging virus involved in outbreaks in Brazil. The association between the virus and vertical transmission, with disorders in the placenta, has raised a worldwide concern. On the 29th gestational week, a pregnant woman presented severe complications due to a DENV infection leading to maternal and fetus death. Postmortem analysis of fetal organs demonstrated the presence of DENV using reverse transcriptase polymerase chain reaction (RT-PCR) in the fetal brain and DENV non-structural protein 3 (NS3) staining in placenta and several peripheral fetal tissues, such as the brain, liver, lungs, and spleen. Histological analysis of the placenta and fetal organs revealed different types of tissue abnormalities, which included inflammation, hemorrhage, edema, and necrosis in placenta and tissue disorganization in the fetus, such as spongiform parenchyma, microglial inflammation, steatosis, hyalinose arteriolar, inflammatory cells in the alveolar septa, and disorganization of the lymphoid follicle. Increased cellularity (macrophage, Hofbauer cells and TCD8+ lymphocytes) and up-regulation of inflammatory mediators such as IFN-γ, TNF-α, RANTES/CCL5, MCP1/CCL2, and VEGF/R2 were detected in the liver, lung, spleen, brain, and placenta, supporting placental and fetus peripheral tissues inflammation. Maternal infection leading to the production of those vascular mediators may alter the vascular permeability, facilitating the virus entry and tissue and barrier dysfunction.
Successful Stereotactic-Guided Vacuum-Assisted Biopsy in the Evaluation of Breast Microcalcifications: A Study in a Single Tertiary Referral Center in the Middle East

Background: Breast microcalcifications are a category of lesions that can lead to malignancies. They remain a major concern in imaging of suspected cases. Vacuum-assisted biopsy (VAB) has been proposed as a safe and effective measure to evaluate microcalcifications. Objectives: The present study aimed to assess the results of VAB for breast microcalcifications. Patients and Methods: This cross-sectional study was conducted on patients with microcalcifications detected on mammograms. Patients were recruited through simple random sampling during 2019 - 2020, based on the inclusion criteria. The inclusion criteria were microcalcifications on mammography, classified as the breast imaging-reporting and data system (BI-RADS) categories 3, 4B, 4C, and 5, and undergoing mammography-guided VAB for the microcalcifications. Patients with missing data and those who could not be followed-up for at least six months were excluded from the study. They were assessed regarding different imaging characteristics of lesions, including the breast density, BI-RADS classification, microcalcification distribution and morphology, and other demographic and clinical features before biopsy. Additionally, the results of stereotactic-guided VAB were assessed for various benign and malignant pathologies of microcalcifications. The results of descriptive and analytical tests for various radiological and pathological features of lesions were reported. Results: A total of 257 patients, with a mean age of 50.3 ± 8.3 yars, were included in this study. Almost half of the patients (n = 125, 48.6%) had a C-grade breast composition. Regarding the BI-RADS classification, 206 (80.2%) patients were diagnosed with 4B lesions, followed by 44 (17.1%) patients with 4C lesions. The assessment of the pattern of microcalcification distribution in imaging showed that more than half of the patients (n = 148, 57.6%) had lesions in multiple groups. The most prevalent morphology of microcalcifications was punctate amorphous (n = 109, 42.4%). The majority of patients (n = 180, 70%) had benign findings in the pathological assessment, and only 69 (26.8%) had malignant features in pathology. The distribution of malignancies differed among various BI-RADS categories. In the 4B category of lesions, there were 166 benign lesions versus 32 malignant lesions, while in the 4C category, there were 10 benign lesions versus 34 malignant lesions (P < 0.001). Conclusion: This study described the findings of successful stereotactic-guided VAB for breast microcalcifications. VAB can be implemented as a promising assessment tool to evaluate suspected breast microcalcifications effectively.
Beyond the tumour microenvironment

In contrast to the once dominant tumour‐centric view of cancer, increasing attention is now being paid to the tumour microenvironment (TME), generally understood as the elements spatially located in the vicinity of the tumour. Thinking in terms of TME has proven extremely useful, in particular because it has helped identify and comprehend the role of nongenetic and noncell‐intrinsic factors in cancer development. Yet some current approaches have led to a TME‐centric view, which is no less problematic than the former tumour‐centric vision of cancer, insofar as it tends to overlook the role of components located beyond the TME, in the ‘tumour organismal environment’ (TOE). In this minireview, we highlight the explanatory and therapeutic shortcomings of the TME‐centric view and insist on the crucial importance of the TOE in cancer progression.
Development of the Halifax Visual Scanning Test: A New Measure of Visual-Spatial Neglect for Personal, Peripersonal, and Extrapersonal Space

Objectives: Visual-spatial neglect is a common attentional disorder after right-hemisphere stroke and is associated with poor rehabilitation outcomes. The presence of neglect symptoms has been reported to vary across personal, peripersonal, and extrapersonal space. Currently, no measure is available to assess neglect severity equally across these spatial regions and may be missing subsets of symptoms or patients with neglect entirely. We sought to provide initial construct validity for a novel assessment tool that measures neglect symptoms equally for these spatial regions: the Halifax Visual Scanning Test (HVST). Methods: In Study I, the HVST was compared to conventional measures of neglect and functional outcome scores (wheelchair navigation) in 15 stroke inpatients and 14 healthy controls. In Study II, 19 additional controls were combined with the control data from Study I to establish cutoffs for impairment. Patterns of neglect in the stroke group were examined. Results: In Study I, performance on all HVST subtests were correlated with the majority of conventional subtests and wheelchair navigation outcomes. In Study II, neglect-related deficits in visual scanning showed dissociations across spatial regions. Four inpatients exhibited symptoms of neglect on the HVST that were not detected on conventional measures, one of which showed symptoms in personal and extrapersonal space exclusively. Conclusions: The HVST appears a useful measure of neglect symptoms in different spatial regions that may not be detected with conventional measures and that correlates with functional wheelchair performance. Preliminary control data are presented and further research to add to this normative database appears warranted. (JINS, 2019, 25, 490–500)
Explanation Hubris and Conspiracy Theories: A Case of the 2016 Presidential Election

While explanations provide the power to understand the world around us, people are often overconfident about their own understanding. We explored how people’s perceptions of their understanding of phenomena is related to endorsement of conspiracy theories. We first tested people’s perceptions of their understanding of the 2016 Presidential electoral process and then measured their beliefs that the election itself was illegitimate, a form of conspiratorial belief. We found that participants who still endorsed high levels of understanding after generating an explanation for the 2016 election were also more likely to endorse the election was illegitimate. However, this finding only obtained for participants who voted for the losing candidate. These results suggest interesting avenues for exploring individual differences that may be related to the illusion of explanatory depth.
Helios but not CD226, TIGIT and Foxp3 is a Potential Marker for CD4+ Treg Cells in Patients with Rheumatoid Arthritis

Background/Aims: Rheumatoid arthritis (RA) is a progressive, chronic, even disabling systemic autoimmune disease. Imbalance between pathogenic immune cells and immunosuppressive cells is associated with the pathogenesis and development of RA and other autoimmune diseases. As Foxp3 is also expressed on activated CD4+ cells in the presence of inflammation, the identification of Treg cells in patients with RA remains a challenge. Methods: Comprehensive analyses were carried out by Flow cytometry. Expression of Helios, CD226, T cell immunoreceptor with Ig and ITIM domains clinical samples and healthy controls. Results: We have systemically examined three potential markers, Helios, CD226 and TIGIT, that are possibly related to Treg identification, and found that Helios expression on CD4+Foxp3+ cells was decreased and negatively correlated with the disease activity of RA patients, while CD226 and TIGIT both showed elevated expression levels in CD4+Foxp3+ cells in RA patients and they were not associated with disease activity of RA patients. Conclusion: Taken together, our findings indicate that CD4+CD25hiCD127low/-Foxp3+Helios+ may represent the real Treg cell population in patients with RA.
Assessing the collective utility of multiple analyses on clinical alcohol use disorder data

OBJECTIVE The objective of this study was to assess the potential of combining graph learning methods with latent variable estimation methods for mining clinically useful information from observational clinical data sets. MATERIALS AND METHODS The data set contained self-reported measures of psychopathology symptoms from a clinical sample receiving treatment for alcohol use disorder. We used the traditional graph learning methods: Graphical Least Absolute Shrinkage and Selection Operator, and Friedman's hill climbing algorithm; traditional latent variable estimation method factor analysis; recently developed graph learning method Greedy Fast Causal Inference; and recently developed latent variable estimation method Find One Factor Clusters. Methods were assessed qualitatively by the content of their findings. RESULTS Recently developed graphical methods identified potential latent variables (ie, not represented in the model) influencing particular scores. Recently developed latent effect estimation methods identified plausible cross-score loadings that were not found with factor analysis. A graphical analysis of individual items identified a mistake in wording on 1 questionnaire and provided further evidence that certain scores are not reflective of indirectly measured common causes. DISCUSSION AND CONCLUSION Our findings suggest that a combination of Greedy Fast Causal Inference and Find One Factor Clusters can enhance the evidence-based information yield from psychopathological constructs and questionnaires. Traditional methods provided some of the same information but missed other important findings. These conclusions point the way toward more informative interrogations of existing and future data sets than are commonly employed at present.
Sleep Pattern Is Related to Mental Health among Chinese Collegiate Student Athletes

Regarding the association between sleep and napping duration and mental health in young and older adults, some studies indicated a positive association, while others indicated a negative, or no, association between them. Moreover, collegiate student athletes have different mental health stressors, such as training pressure, improving sports performance, and relationships with coaches. Therefore, sleep is important for athletes. Whether sleep duration is related to their mental health is unclear. Thus, this study aimed to examine the association between nighttime sleep duration, daytime napping duration, and mental health among collegiate student athletees. This cross-sectional study included 700 college athletes. Sleep and daytime napping durations were assessed using a self-reported questionnaire. The Zung Self-rating Depression Scale and Generalized Anxiety Disorder-7 assessed mental health. A multivariate logistic regression analysis was conducted to examine the adjusted association between sleep duration and mental health. In this study, the odds ratios for depression and anxiety symptoms were significantly higher for short sleep duration (<7 h). Additionally, a significant positive association was found between daytime napping duration and the prevalence of depression. This study indicates that short nighttime sleep and long daytime napping duration may be risk factors for collegiate student athletes’ mental health, having important implications for educators and coaches.
KMT2C-deficient tumors have elevated APOBEC mutagenesis and genomic instability in multiple cancers

Abstract The histone methyltransferase KMT2C is among the most frequently mutated epigenetic modifier genes in cancer and plays an essential role in MRE11-dependent DNA replication fork restart. However, the effects of KMT2C deficiency on genomic instability during tumorigenesis are unclear. Analyzing 9,663 tumors from 30 cancer cohorts, we report that KMT2C mutant tumors have a significant excess of APOBEC mutational signatures in several cancer types. We show that KMT2C deficiency promotes APOBEC expression and deaminase activity, and compromises DNA replication speed and delays fork restart, facilitating APOBEC mutagenesis targeting single stranded DNA near stalled forks. APOBEC-mediated mutations primarily accumulate during early replication and tend to cluster along the genome and also in 3D nuclear domains. Excessive APOBEC mutational signatures in KMT2C mutant tumors correlate with elevated genome maintenance defects and signatures of homologous recombination deficiency. We propose that KMT2C deficiency is a likely promoter of APOBEC mutagenesis, which fosters further genomic instability during tumor progression in multiple cancer types.