Miracle-dz/UniFAR-FTUs huggingface dataset:
Antimicrobial, Antibiofilm, and Antioxidant Activity of Functional Poly(Butylene Succinate) Films Modified with Curcumin and Carvacrol

The use of food industry waste as bioactive compounds in the modification of biodegradable films as food packaging remains a major challenge. This study describes the preparation and bioactivity characterization of poly(butylene succinate) (PBS)-based films with the addition of the bioactive compounds curcumin (CUR) and carvacrol (CAR). Films based on PBS modified with curcumin and carvacrol at different concentration variations (0%/0.1%/1%) were prepared by solvent casting method. The antioxidant, antimicrobial, and antibiofilm properties were investigated against bacteria (Escherichia coli, Staphylococcus aureus) and fungi (Candida albicans). As a result of the modification, the films exhibited free radicals scavenging (DPPH up to 91.47% and ABTS up to 99.21%), as well as antimicrobial (6 log, 4 log, and 2 log reductions for E. coli, S. aureus, and C. albicans, respectively, for samples modified with 1% CUR and 1% CAR) activity. Moreover, antibiofilm activity of modified materials was observed (8.22–87.91% reduction of biofilm, depending on bioactive compounds concentration). PBS films modified with curcumin and carvacrol with observed bifunctional properties have many potential applications as active packaging.
Top Management Team Stability and Corporate Social Responsibility: The Moderating Effects of Performance Aspiration Gap and Organisational Slack

Although studies on the impact of senior executives on corporate social responsibility (CSR) are relatively sufficient, they take a static perspective when investigating the different attitudes of senior executives towards fulfilling social responsibility. Few studies consider the impact of the dynamic changes in a top management team (TMT) on sustainable corporate development, especially social responsibility. We perform regression analysis on 2010–2019 data from Chinese listed firms to examine the relationship between TMT stability and CSR performance and consider the moderating roles of the performance aspiration gap and slack resources. We find that TMT stability has a positive impact on CSR performance and that the performance aspiration gap and slack resources negatively moderate the relationship between TMT stability and CSR performance. This study expands the current literature on the relationship between TMT characteristics and social responsibility, sheds light on what situations can cause agency problems, and provides practical guidance for the sustainable development of a firm and adequate performance of CSR.
Bacterial-Based Cancer Therapy (BBCT): Recent Advances, Current Challenges, and Future Prospects for Cancer Immunotherapy

Currently approximately 10 million people die each year due to cancer, and cancer is the cause of every sixth death worldwide. Tremendous efforts and progress have been made towards finding a cure for cancer. However, numerous challenges have been faced due to adverse effects of chemotherapy, radiotherapy, and alternative cancer therapies, including toxicity to non-cancerous cells, the inability of drugs to reach deep tumor tissue, and the persistent problem of increasing drug resistance in tumor cells. These challenges have increased the demand for the development of alternative approaches with greater selectivity and effectiveness against tumor cells. Cancer immunotherapy has made significant advancements towards eliminating cancer. Our understanding of cancer-directed immune responses and the mechanisms through which immune cells invade tumors have extensively helped us in the development of new therapies. Among immunotherapies, the application of bacteria and bacterial-based products has promising potential to be used as treatments that combat cancer. Bacterial targeting of tumors has been developed as a unique therapeutic option that meets the ongoing challenges of cancer treatment. In comparison with other cancer therapeutics, bacterial-based therapies have capabilities for suppressing cancer. Bacteria are known to accumulate and proliferate in the tumor microenvironment and initiate antitumor immune responses. We are currently well-informed regarding various methods by which bacteria can be manipulated by simple genetic engineering or synthetic bioengineering to induce the production of anti-cancer drugs. Further, bacterial-based cancer therapy (BBCT) can be either used as a monotherapy or in combination with other anticancer therapies for better clinical outcomes. Here, we review recent advances, current challenges, and prospects of bacteria and bacterial products in the development of BBCTs.
Recall of B cell memory depends on relative locations of prime and boost immunization

Immunization or microbial infection can establish long-term B cell memory not only systemically but also locally. Evidence has suggested that local B cell memory contributes to early local plasmacytic responses after secondary challenge. However, it is unclear whether locality of immunization plays any role in memory B cell participation in recall germinal centers (GCs), which is essential for updating their B cell antigen receptors (BCRs). Using single B cell culture and fate mapping, we have characterized BCR repertoires in recall GCs after boost immunizations at sites local or distal to the priming. Local boosts with homologous antigen recruit the progeny of primary GC B cells to recall GCs more efficiently than do distal boosts. Recall GCs elicited by local boosts contain significantly more B cells with elevated levels of immunoglobulin (Ig) mutation and higher avidity BCRs. This local preference is unaffected by blocking CD40:CD154 interaction to terminate active, GC responses. Local boosts with heterologous antigens elicit secondary GCs with B cell populations enriched for cross-reactivity to the prime and boost antigens; in contrast, cross-reactive GC B cells are rare after distal boosts. Our results suggest that local B cell memory is retained in the form of memory B cells, GC B cells, and GC phenotype B cells that are independent of organized GC structures and that these persistent “primed B cells” contribute to recall GC responses at local sites. Our findings indicate the importance of locality in humoral immunity and inform serial vaccination strategies for evolving viruses. Description The participation of memory B cells in recall germinal centers depends on whether the boost is local or distal to the priming site. Local booster shots are superior Germinal center (GC) responses to vaccination or infection generate memory B cells that contribute to long-term protective immunity. Whether location of immunization affects memory B cell recall into secondary GC responses remains to be determined. Kuraoka et al. used a prime boost immunization approach, whereby mice received a homologous antigen booster on the same (ipsilateral) or opposite (contralateral) leg. The magnitude and serum antibody responses were similar for ipsilateral and contralateral boosters; however, ipsilateral boosters elicited better quality GCs with higher avidity for antigen, higher immunoglobulin mutation frequencies, and increased recall of B cells from primary GCs. These results indicate that reactivation of local memory B cells generates superior secondary GC responses and suggest that location of booster immunization should be considered in vaccination strategies.
Perceptions of technology uncertainty and the consequences for performance in buyer-supplier relationships

In this paper, we investigate how buyers’ and suppliers’ distinct perceptions of technology uncertainty affect the relationship between communication frequency and supplier performance. Information processing theory suggests that a fit is desirable between perceived environmental uncertainty and the communication processes between organisations. However, if partners in a buyer-supplier relationship do not concur on the high level of technology uncertainty, it is highly questionable whether increased communication will be effective in increasing supplier performance. Using dyadic data from 86 buyer-supplier relationships, involving 388 respondents, we found that communication frequency was positively related to supplier performance only when both suppliers and buyers perceived high levels of technology uncertainty. When buyers perceived greater technology uncertainty than their suppliers, communication frequency was negatively related to supplier performance. The findings in this study show that it is important to take the distinct perceptions of buyers and suppliers of technology uncertainty into account when assessing the effects of communication frequency. It appears that increased communication is only effective when both parties acknowledge the need to communicate, and can be unfavourable when only one party sees the benefits of it.
Temporal in vivo platelet labeling in mice reveals age-dependent receptor expression and conservation of specific mRNAs

The proportion of young platelets, also known as newly formed or reticulated, within the overall platelet population has been clinically correlated with adverse cardiovascular outcomes. Our understanding of this is incomplete, however, because of limitations in the technical approaches available to study platelets of different ages. In this study we have developed and validated an in vivo ‘temporal labelling’ approach using injectable fluorescent anti-platelet antibodies to sub-divide platelets by age and assess differences in functional and molecular characteristics. With this approach we found that young platelets (<24h old) in comparison to older platelets respond to stimuli with greater calcium flux and degranulation, and contribute more to the formation of thrombi in vitro and in vivo. Sequential sampling confirmed this altered functionality to be independent of platelet size with no size differences or changes relative to the global population seen at any age. The age associated decrease in thrombotic function was accompanied by significant decreases in the surface expression of GPVI and CD31 (PECAM-1) and an increase in CD9. Platelet mRNA content also decreased with age but at different rates for individual mRNAs indicating apparent conservation of those encoding granule proteins. Our pulse-chase type approach to define circulating platelet age has allowed timely re-examination of commonly held beliefs regarding size and reactivity of young platelets whilst providing novel insights into the temporal regulation of receptor and protein expression. Overall, future application of this validated tool will inform on age-based platelet heterogeneity in physiology and disease.
A Study of Differences in Compulsory Courses Offering Medicine Humanization and Medical Communication in Polish Medical Schools: Content Analysis of Secondary Data

Medical humanity is an essential element of medical education, and the respective courses are introduced to the curricula of medical schools worldwide. However, significant differences in this type of medical education were identified in Italy, Spain, and the UK. In Poland, this issue was not yet analyzed. The classes offered on a compulsory and not elective basis secure the uniform skills of future physicians. Therefore, we were prompted to ask a question: do Polish medical students receive equal compulsory education in medical humanities? To answer that question, we performed a content analysis of mandatory classes’ frequency, types, and content on medical humanization and communication in Polish medical schools. The study used publicly available information provided on the home pages of the universities to perform content and comparative analyses. Of 22 identified universities, 15 had publicly listed teaching programs, and nine had freely available syllabi. The names and types of courses varied from school to school. The number of hours the courses offered throughout medical education ranged from 15 to 216. In some medical schools, the classes were scheduled during the early, pre-clinical part of the study, whereas in other schools they were offered each year. The content of the courses always covered the topics of physician–patient communication but rarely offered protocols, such as the Calgary Cambridge guide. We conclude that the medical humanities represented by medical humanization and communication courses are included in the publicly available compulsory curriculum of most Polish medical schools. However, to secure equal education of future Polish physicians, there is a need to unify the medical humanities program.
State of injury: liberal multiculturalism and the Muslim subject after prison

ABSTRACT The liberal political project has come under scrutiny for its unfulfilled promises of freedom and equality for those at the margins of society. This contribution approaches the critical analysis of state-citizen relations through inquiring into how liberal secular governance enables, limits, and reshapes moral and ethical potentialities. It draws on a study of Muslim men under probation supervision in East London and their relationships with their empathetic probation officers to show how the state can direct Muslim-citizen subjects in virtuous and restorative ways but also in ways that mark ‘injury’, directing subjectivities towards cooperation with exclusionary state practices. Taking an intersectional approach and through attention to pain, this contribution argues that the state is intimately invested in subject formation, but its effects are uneven and polarised according to its own sovereignty and governing logics. The uneven subjectivities reflect the ‘precarity’ of governing Muslims at the margins directed towards inclusion and exclusion, assisting and controlling, care and punishment.
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer’s Disease

The identification of effective pharmacological tools for Alzheimer’s disease (AD) represents one of the main challenges for therapeutic discovery. Due to the variety of pathological processes associated with AD, a promising route for pharmacological intervention involves the development of new chemical entities that can restore cellular homeostasis. To investigate this strategy, we designed and synthetized SG2, a compound related to the thyroid hormone thyroxine, that shares a pleiotropic activity with its endogenous parent compound, including autophagic flux promotion, neuroprotection, and metabolic reprogramming. We demonstrate herein that SG2 acts in a pleiotropic manner to induce recovery in a C. elegans model of AD based on the overexpression of Aβ42 and improves learning abilities in the 5XFAD mouse model of AD. Further, in vitro ADME-Tox profiling and toxicological studies in zebrafish confirmed the low toxicity of this compound, which represents a chemical starting point for AD drug development.
Changing Technological Pedagogical Content Knowledge (TPACK) through Course Experiences

Teachers’ understanding of Technological Pedagogical Content Knowledge is critical in accomplishing successful technology integration in teaching. This study investigated how inservice teachers’ beliefs about teaching and technology changed as a result of a set of educational technology summer courses, conducted both face-to-face and online. A single-group pretestposttest design was used to examine how in-service teachers’ understanding of the relationships between technology, content, and pedagogy changed over the semester. Twenty-three graduate students completed both the pre-test survey and post-test survey on teachers’ knowledge of teaching and technology. The results of dependent t-tests on each of the twelve sub-scales suggested that students gained deeper and more complex understanding of technological pedagogical content knowledge.
Study on onset of nucleate boiling with screw tube for fusion reactor application

The onset of nucleate boiling (ONB) is the point at which the heat transfer mechanism in fluids changes and is one of the thermo-hydraulic factors that must be considered when establishing a cooling system operation strategy. Because the high heat flux of several MW m−2, which is loaded within a tokamak, is applied under a one-side heating condition, it is necessary to determine a correlative relation that can predict ONB under special heating conditions. In this study, the ONB of a one-side-heated screw tube was experimentally analyzed via a subcooled flow boiling experiment. The helical nut structure of the screw tube flow path wall allows for improved heat transfer performance relative to plain tubes, providing a screw tube with a 53.98% higher ONB than a plain tube. The effects of the system parameters on the ONB heat flux were analyzed based on the changes in the heat transfer mechanism, with the results indicating that the flow rate and degree of subcooling are proportional to the ONB heat flux because increasing these factors improves the forced convection heat transfer and increases the condensation rate, respectively. However, it was observed that the liquid surface tension and latent heat decrease as the pressure increases, leading to a decrease in the ONB heat flux. An evaluation of the predictive performance of existing ONB correlations revealed that most have high error rates because they were developed based on ONB experiments on micro-channels or plain tubes and not under one-side high heat load conditions. To address this, we used dimensional analysis based on Python code to develop new ONB correlations that reflect the influence of system parameters.
Exploring Cognitive Work within a 911 Dispatch Center: Using Complementary Knowledge Elicitation Techniques

This study evaluates the differences in user information acquired from scenario-based versus non scenario-based knowledge elicitation for the design of 911 dispatch simulations. During the non-scenario condition, participants answered probe questions concerning their work activities and emergency response procedures. During the scenario-based condition, participants were presented with an emergency scenario and described the necessary steps required to respond to the situation. Preliminary analysis implies that information derived from non scenario-based knowledge elicitation may focus more upon the defined protocols of workgroups whereas information gathered from scenario-based knowledge elicitation may be more concerned with procedures and interactions that are unique to a certain workgroup. Results suggest that the use of scenario-based knowledge elicitation is more likely to allow designers to tailor simulations that conform to the unique culture of an emergency dispatch center workgroup than non scenario-based knowledge elicitation.
A Robot, Meteorologist, and Amateur Forecaster Walk into A Bar: Examining Qualitative Responses to A Weather Forecast Delivered via Social Robot

ABSTRACT The current study examines qualitative responses from participants about their opinions on a weather forecast delivered by a professional meteorologist, an amateur meteorologist, and a social robot standing in for a meteorologist. Through thematic analyses, this study identified that people evaluated each weather forecast agent’s performance based on two major criteria: message factors and messenger factors. Two themes emerged from the category of message factors: an enjoyable/entertaining experience and commentary on the forecast content and information. Five themes were identified under the category of messenger factors: an expectancy violation or uncertainty which made participants uncomfortable, a distraction to the point it impeded focus on the forecast, vocalization concerns, unprofessional delivery, and commentary on the stimuli being “cute”/perceiving it as a joke. Findings further illustrate the expectancy violation people experienced while encountering a robot and/or amateur forecaster. Such knowledge will contribute to human-machine communication literature and offer pragmatic implications for technology development.
Self-sufficiency Assessment: Defining the Foodshed Spatial Signature of Short Beef Supply Chains

: Foodshed approaches allow the assessment of the theoretical food self-sufficiency capacity of a specific region based on biophysical conditions. Recent analyses show that the focus needs to be shifted from foodshed size portrayed as an isotropic circle to a commodity-group-specific spatial configuration of the foodshed that takes into account the socio-economic and biophysical conditions essential to the development of local food supply chains. We focus on a specific animal product (beef) and use an innovative modeling approach based on spatial analysis to detect the areas of the foodshed dedicated to beef feeding (forage, pasture, and grassland), considering the foodshed as a complex of complementary areas called an archipelago. We use available statistical data including a census to address the city-region of Avignon (France) covering a 100 km radius. Our results show that the factors driving the use of short supply chains for beef feeding areas are the foodshed archipelago’s number of patches, the connectivity between them, and the rugosity of the boundaries. In addition, our beef self-sufficiency assessment results differ depending on geographical context. For instance, being located within the perimeters of a nature park seems to help orient beef production towards short supply chains. We discuss possible leverage for public action to reconnect beef production areas to consumption areas (the city) via short supply chains (e.g. green, home-grown school food programs) so as to increase local food security through increased local food self-sufficiency.
SDA full-wave analysis of boxed multistrip superconducting lines of finite thickness embedded in a layered lossy medium

The spectral-domain approach is applied to modeling the propagation characteristics of a multiconductor structure of superconducting strip lines with signal strips and ground planes of finite thickness in lossy layered media. Two sets of basis functions (Chebyshev and Legendre polynomials) are compared by their ability for accurate modeling of microwave losses. Simple expressions within the immitance approach are presented for a power flux computation. As a result, complex propagation constants and related modal impedances of a multiconductor structure containing superconducting strips can be calculated with a high accuracy. The model applicability is illustrated by numerical results compared with available simulated data.
Language and Aggression in Preschool Children. Gender Differences

The present study has two objectives. Firstly to analyze the gender differences in language development in preschool children and secondly to analyze the relationships between language development on the one hand and aggression, prosocial behavior on the other hand. The study involved 155 preschool children aged between 36 and 71 months (M = 52.61, SD = 10.40) enrolled in a kindergarten in Bucharest. The instruments used were the Adaptive Behavior Assessment System, ABAS-II (Harrison et al., 2012) and Preschool Social Behavior Scale - Teacher Form (Crick, 1996). To determine the gender differences, a series of independent samples t tests and Mann-Whitney U nonparametric test were performed and for the relationships among variables, regression and moderation analyzes were performed. The results showed that girls have higher levels of language development than boys, in all measured dimensions. At the same time, the level of language development was negatively associated with physical and relational aggression and positively with prosocial behavior. Contrary to our expectations, gender has not moderated the relationship between language development and aggression or prosocial behavior. The practical implications of the study address the need to capture and treat early delays in language development in order to prevent aggressive behaviors among preschoolers.