Miracle-dz/UniFAR-FTUs huggingface dataset:
Statistical analysis of image differences by wavelet decomposition

The wavelet transform was studied for the analysis of glucose utilization differences between subject groups shown in PET images. To strengthen statistical inference, it was of particular interest investigating the trade-off between signal localization and image decomposition into uncorrelated components. This trade-off is governed by wavelet regularity, and was found to be best for third-order orthogonal spline wavelets. Only about 1.6% of the components were statistically different (p<.05) from noise, constituting a sufficient set to synthesize local image differences by the inverse wavelet transform. <<ETX>>
Nitrostilbenes: Synthesis and Biological Evaluation as Potential Anti-Influenza Virus Agents

Resveratrol (RSV) is a natural stilbene polyphenolic compound found in several plant species. It is characterized by antioxidant properties, and its role in controlling viral replication has been demonstrated for different viral infections. Despite its promising antiviral properties, RSV biological activity is limited by its low bioavailability and high metabolic rate. In this study, we optimized its structure by synthesizing new RSV derivatives that maintained the phenolic scaffold and contained different substitution patterns and evaluated their potential anti-influenza virus activity. The results showed that viral protein synthesis decreased 24 h post infection; particularly, the nitro-containing compounds strongly reduced viral replication. The molecules did not exert their antioxidant properties during infection; in fact, they were not able to rescue the virus-induced drop in GSH content or improve the antioxidant response mediated by the Nrf2 transcription factor and G6PD enzyme. Similar to what has already been reported for RSV, they interfered with the nuclear-cytoplasmic traffic of viral nucleoprotein, probably inhibiting cellular kinases involved in the regulation of specific steps of the virus life cycle. Overall, the data indicate that more lipophilic RSV derivatives have improved antiviral efficacy compared with RSV and open the way for new cell-targeted antiviral strategies.
Hybrid Discontinuous Galerkin Methods with Relaxed H(div)-Conformity for Incompressible Flows. Part I

The present work is the second part of a pair of papers, considering Hybrid Discontinuous Galerkin methods with relaxed H(div)-conformity. The first part mainly dealt with presenting a robust analysis with respect to the mesh size h and the introduction of a reconstruction operator to restore divergence-conformity and pressure robustness (pressure independent velocity error estimates) using a modified force discretization. The aim of this part is the presentation of a high order polynomial robust analysis for the relaxed H(div)-conforming Hybrid Discontinuous Galerkin discretization of the two dimensional Stokes problem. It is based on the recently proven polynomial robust LBB-condition for BDM elements, Lederer and Schöberl (IMA J. Numer. Anal. (2017)) and is derived by a direct approach instead of using a best approximation Céa like result. We further treat the impact of the reconstruction operator on the hp analysis and present a numerical investigation considering polynomial robustness. We conclude the paper presenting an efficient operator splitting time integration scheme for the Navier–Stokes equations which is based on the methods recently presented in Lehrenfeld and Schöberl (Comp. Methods Appl. Mech. Eng. 307 (2016) 339–361) and includes the ideas of the reconstruction operator.
Observations concerning the generation and propagation of Type III solar bursts

A number of Type III bursts were observed during the Helios missions in which the burst exciter passed over the spacecraft, as evidenced by strong electric field fluctuations near the plasma frequency. Six of these were suitable for detailed study. Of the six events, one was ambiguous, one showed what is interpreted as a switchover from harmonic to fundamental, and the rest all generated fundamental at onset. This would be expected if both fundamental and harmonic are generated, as, at a fixed frequency, the fundamental will be generated earlier. For the event which seems to show both fundamental and harmonic emission, the frequency ratio is not exactly 2. This is explained in terms of a time delay of the fundamental, due to scattering and diffusion in the source region. A time delay of the order of 600 seconds at 1 AU and 20 kHz, and inversely proportional to frequency, is required to explain the observations. Crude estimates show that delay times at least this long may be attributed to trapping and scattering.
Amygdala neural ensemble mediates mouse social investigation behaviors

ABSTRACT Innate social investigation behaviors are critical for animal survival and are regulated by both neural circuits and neuroendocrine factors. Our understanding of how neuropeptides regulate social interest, however, is incomplete at the current stage. In this study, we identified the expression of secretin (SCT) in a subpopulation of excitatory neurons in the basolateral amygdala. With distinct molecular and physiological features, BLASCT+ cells projected to the medial prefrontal cortex and were necessary and sufficient for promoting social investigation behaviors, whilst other basolateral amygdala neurons were anxiogenic and antagonized social behaviors. Moreover, the exogenous application of secretin effectively promoted social interest in both healthy and autism spectrum disorder model mice. These results collectively demonstrate a previously unrecognized group of amygdala neurons for mediating social behaviors and suggest promising strategies for social deficits.
MONOCLONAL ANTIBODIES IN THE TREATMENT OF NON-HODGKIN'S LYMPHOMAS

Summary Monoclonal antibodies are an exciting advance in the treatment of lymphoma. They are safe and well-tolerated, and exhibit little cross-resistance with conventional chemotherapeutic agents. In indolent lymphomas, antibody has shown useful response rates both as first line therapy and in relapsed disease. Follicular lymphomas appear to be particularly sensitive to rituximab, and chronic lymphocytic leukaemia to alemtuzumab. In aggressive lymphomas, the addition of rituximab to CHOP chemotherapy significantly prolongs disease-free and overall survival compared to CHOP alone as first-line therapy. Novel agents, including radiolabelled antibodies are showing promise in phase I and II trials in a vari-ety of clinical settings.
Pengujian Empiris Brand Satisfaction terhadap Brand Loyalty yang di Moderasi oleh Emotional Brand Attachment dan Brand Love

Penelitian ini bertujuan menguji untuk emotional brand attachment, dan brand love sebagai mediator atas brand satisfaction terhadap brand loyalty. Teknik pengambilan sampel yang digunakan adalah purposive sampling, yaitu pengguna aktif smartphone Samsung dengan jumlah sampel 150 responden. Data dikumpulkan dengan penyebaran kuesioner menggunakan Google Form. Pengujian hipotesis dengan menggunakan Structural Equation Modelling (SEM). Hasil pengujian membuktikan bahwa brand satisfaction berpengaruh positif terhadap emotional brand attachment, dan brand loyalty. Demikian pula brand satisfaction terhadap emotional brand attachment dan brand love berpengaruh positif terhadap brand loyalty. Sekaligus mengindikasikan adanya peran mediasi parsial dari emotional brand attachment dan brand love antara brand satisfaction dan brand loyalty. Implikasinya bahwa brand loyalty akan semakin kuat dengan adanya keterikatan emosional konsumen pada merek dan perasaan cinta konsumen pada merek maka akan semakin setia konsumen untuk terus menggunakan merek tersebut. Dan untuk menyempurnakan model penelitian ini dengan menambahkan variabel-variabel yang mempengaruhi brand satisfaction yaitu perceived quality, perceived value of cost, brand trust, dan lifestyle congruence dalam penelitian berikutnya.
Host Species and Captivity Distinguish the Microbiome Compositions of a Diverse Zoo-Resident Non-Human Primate Population

Vast numbers of microorganisms inhabit the mammalian gastrointestinal tract in a complex community referred to as the gut microbiome. An individual’s microbiome may be impacted by genetics, diet, and various environmental factors, and has been associated with many health states and diseases, though specific explanations are lacking. While these communities are well-studied in human populations, non-human primates (NHPs), in particular zoo-resident or captive NHPs, offer distinct advantages to increasing our understanding of factors that influence gut microbiome composition. Here, we characterize the gut microbiome composition of a phylogenetically diverse cohort of NHPs residing in the same urban zoo. We show that despite overlapping and controlled environmental contexts, gut microbiomes are still distinguished between NHP host species. However, when comparing the zoo cohort to wild NHPs, we show that captivity status strongly distinguishes zoo-resident NHPs from their wild counterparts, regardless of host phylogeny. Microbial orders unique to captive NHPs include taxa commonly present in human gut microbiomes. Together, these results demonstrate that differences between NHP species are strongly associated with gut microbiome composition and diversity, suggesting that species-specific approaches should be considered when investigating environmental factors’ influence on gut microbiome composition.
Textural Properties of Bakery Products: A Review of Instrumental and Sensory Evaluation Studies

Bakery products are an important sector of the food industry globally and are part of the regular diets of many people. Texture encompasses many product characteristics and plays a pivotal role in consumer acceptance. This review focuses on the studies that evaluate textural properties in a set of bakery products, either using instrumental texture measurements or sensorial evaluations. A search was conducted on scientific databases, and selection was based on some eligibility criteria, resulting in a total of 133 articles about the textural properties of bakery products. Of these studies, the majority reported only instrumental analysis of texture (62 out of 133), and a minor number of studies reported only sensorial analyses (n = 14). Still, there was an expressive number of studies in which both methodologies were used to assess the texture of the bakery products (n = 57), i.e., instrumental measurement complemented with sensory evaluation. The results showed that most studies focused on bread (37%) and cakes (33%). With respect to instrumental texture analysis, most tests were TPA (texture profile analysis), and the most commonly used probe was a cylinder disc with a 75 mm diameter. Instrumental tests usually determine textural properties like hardness, cohesiveness, chewiness, and springiness. Regarding the sensorial analyses of texture, mostly descriptive tests were used (72%), particularly sensory profiling, with a lower number of studies performing discriminating (18%) of preference/acceptance tests (10%). In most cases, untrained panels were used, with a most common number of panelists equal to ten, and the most representative evaluated textural attributes were hardness, cohesiveness, chewiness, and springiness. In conclusion, this review provides insight into the methods used to assess the texture of bakery products and which characteristics of these products should be on focus. Furthermore, it was verified that both types of methodologies are complementary in evaluating texture for these types of food products.
Effects of Running-Specific Strength Training, Endurance Training, and Concurrent Training on Recreational Endurance Athletes’ Performance and Selected Anthropometric Parameters

Objective: The present study aimed to verify the effects of running-specific strength training alone, endurance training alone, and concurrent training on recreational endurance athletes’ performance and selected anthropometric parameters. Method: Thirty male recreational endurance runners were randomly assigned using a blocking technique to either a running-specific strength training group (RSSTG), an endurance training group (ETG), or a concurrent training group (CTG). RSSTG performed three strength-training sessions per week orientated to running, ETG underwent three endurance sessions per week, and CTG underwent a 3-day-per-week concurrent training program performed on non-consecutive days, alternating the strength and endurance training sessions applied to RSSTG and ETG. The training protocol lasted 12 weeks and was designed using the ATR (Accumulation, Transmutation, Realization) block periodization system. The following assessments were conducted before and after the training protocol: body mass (BM), body mass index (BMI), body fat percentage (BFP), lean mass (LM), countermovement jump (CMJ), 1RM (one-repetition maximum) squat, running economy at 12 and 14 km/h (RE12 and RE14), maximum oxygen consumption (VO2max), and anaerobic threshold (AnT). Results: RSSTG significantly improved the results in CMJ, 1RM squat, RE12, and RE14. ETG significantly improved in RE12, RE14, VO2max, and AnT. Finally, CTG, obtained significant improvements in BFP, LM, CMJ, 1RM squat, RE12, RE14, VO2max, and AnT. RSSTG obtained improvements significantly higher than ETG in CMJ, 1RM squat, and RE14. ETG results were significantly better than those attained by RSSTG in AnT. Moreover, CTG marks were significantly higher than those obtained by ETG in CMJ and RE14. Conclusion: Performing a 12-week concurrent training program integrated into the ATR periodization system effectively improves body composition and performance variables that can be obtained with exclusive running-specific strength and endurance training in recreational runners aged 30 to 40. Running-specific strength training enhances maximum and explosive strength and RE, whereas exclusive endurance training improves VO2max, AnT, and RE. Performing concurrent training on non-consecutive days effectively prevents the strength and endurance adaptations attained with single-mode exercise from being attenuated. The ATR periodization system is useful in improving recreational endurance athletes’ performance parameters, especially when performing concurrent training programs.
Smoking cessation intervention prior to orthopedic surgery: A study protocol to determine patient outcomes and feasibility

The aim of the study is to analyze the effect of smoking and smoking cessation on the incidence of complications among orthopedic and hand surgery patients, and to determine the feasibility of smoking cessation intervention, as well as factors predicting success in smoking cessation. Orthopedic and hand surgery patients will be invited to participate in the study, which will recruit 550 participants (at least 20% daily smokers). A participant will be defined as a daily smoker if he/she reports daily smoking and/or laboratory tests show active smoking. Data will be collected using a self-reported questionnaire and from medical records. Smokers will receive information about the benefits of smoking cessation and will be encouraged to quit. Medication or nicotine replacement therapy will be prescribed. Laboratory tests will be taken two weeks before and two weeks after surgery. Follow-up phone calls will be made at 3, 6, and 12 months after surgery. The primary outcome is any complication, defined as a prolonged stay in hospital or any additional visit to or measure taken by a health service during the 12 months after surgery. Data on complications are mainly obtained from personal health records and from the information received at the follow-up; the rest of the data will be collected from the register of healthcare-associated infections. Secondary outcomes are the number and types of complications. The sample (n=550) was calculated to observe a 10% difference in complications between smokers and non-smokers (5% alpha level and 80% power), considering a 10% drop-out rate. Logistic regression and log-linear models will be used for data analyses.
Scoping Review: Evaluation of Moringa oleifera (Lam.) for Potential Wound Healing in In Vivo Studies

Wound healing is a natural process to restore damaged tissues due to loss of tissue integrity. Moringa oleifera (locally known as merunggai in Malaysia) has been traditionally used in various ailments, including for wound management. To evaluate the wound healing properties in M. oleifera, publications were searched and selected following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement with predetermined inclusion criteria. The databases searched for primary studies include PubMed, Google Scholar, Science Direct, LILACS, ClinicalTrials.gov, and CENTRAL. In total, 18 in vivo studies were included, which involved the leaves, while the remaining 5 studies involved other plant parts tested on excision, incision, dead space, abrasion, and burn-induced wound models. All studies reported significant wound healing abilities. Most studies used different topical formulations of aqueous leaves extract. The accumulation of collagen content and underlying wound healing mechanism through antimicrobial, antioxidant, and anti-inflammatory activities may be contributed by its bioactive phytochemical content, which has the potential to accelerate the wound contraction, increase the rate of epithelialization, and protect tissues against oxidative damage. In conclusion, M. oleifera showed wound healing potential but further studies are warranted to determine the main bioactive phytocompounds and safety.
Protective effect of pantothenic acid in kainic acid-induced status eilepticus and associated neurodegeneration in mice

Pantothenic acid (PA) is a water-soluble vitamin (Vitamin B) that has recently been investigated in various chemical-induced neurotoxicity studies. The present study was designed to explore the biological importance of PA as a neuromodulator by releasing monoamine oxidase (MAO)-A and MAO-B in kainic acid (KA)-induced status epilepticus and the associated neurodegeneration in mice. The mice were intraperitoneally administered with KA at a dose of 10 mg/kg, and the injection solution was maintained at pH 7.2 ± 0.1 before the injection. Subsequently, the mice were observed for various behavioral changes, such as grooming, rearing, hind limb scratching, urination, defecation, jaw movements, salivation, head nodding, incidence of convulsions, and their latency or any mortality, which were recorded during a 4-h period. Further, the animals were euthanized for biochemical and histopathological analysis. The oxidative stress status was determined by measuring levels of glutathione, superoxide dismutase, nitrites, and catalase enzymes. The MAO-A and MAO-B activities, which represent an indicator of brain memory function, and the level of tumor necrosis factor alpha, which is an inflammatory marker in brain tissues, were also measured. The PA pre-treated mice showed a significant increase in retention with latency, as demonstrated in the passive avoidance test, which indicate its protective effect against the KA-induced cognitive deficit. The results showed that the anti-oxidative and anti-inflammatory potential of PA is due to the change in lipid peroxidation, which may prevent mitochondrial damage in neuronal cell, thereby conferring neuroprotection.
Information structure : theoretical, typological, and experimental perspectives

1. Introduction PART I TOPIC AND FOCUS 2. Second Occurrence Focus and Relativized Stress F 3. How Focus and Givenness Shape Prosody 4. Structural Focus and Exhaustivity 5. The Interpretation of Topical Indefinites as Direct and Indirect Aboutness Topics 6. Contrastive Topics Operate on Speech Acts 7. Biased Questions, Intonation, and Discourse PART II CROSS-LINGUISTIC VARIATION AND DIACHRONIC CHANGE 8. Towards a Typology of Focus Realization 9. Focus in Aghem 10. Subject Focus in West African Languaegs 11. Information Structure and OV Order 12. Information Structure and Unmarked Word Order in (Older) Germanic PART III EXPERIMENTAL AND PSYCHOLINGUISTIC APPROACHES TO INFORMATION STRUCTURE 13. Effects of Givenness and Constraints on Free Word order 14. Investigating Effects on Structural and Information-Structural Factors on Pronoun Resolution 15. Given and New Information in Spatial Statements
Concurrent Typhoid Fever and Dengue Hemorrhagic Fever: A Case Report

Dengue virus can co-infect with a number of viruses, bacteria, and parasites of which dengue malaria co-infection is most well-known. We report a rare case of dengue virus co-infection with typhoid fever and the development of dengue hemorrhagic fever (DHF) during a dengue outbreak. The second spike of high-grade fever following initial defervescence with antibiotic therapy, hemorrhagic manifestations, new onset leucopenia and thrombocytopenia, and evidence of plasma leakage raised suspicion of DHF. Diagnosis of dengue co-infection was made by seroconversion for anti-dengue immunoglobulin M (IgM) antibodies by enzyme-linked immunosorbent assay (ELISA) on the seventh day of new-onset fever. Early recognition and judicious use of fluid therapy prevented the patient from developing shock and its complications. Prompt diagnosis, early recognition of plasma leakage, and appropriate management of DHF can reduce morbidity and mortality.
An evidence‐based practice guideline of the National Society of Genetic Counselors for telehealth genetic counseling

There are currently no practice guidelines available for genetic counseling using telehealth modalities. This evidence‐based practice guideline was developed in response to increasing use of alternative service delivery models for genetic counseling, specifically telephone and video‐based genetic counseling (telehealth genetic counseling or THGC). A recent systematic evidence review (SER) compared outcomes of THGC with in‐person genetic counseling and found that for the majority of studied outcomes, THGC was a non‐inferior and comparable service delivery model. The SER results were used to develop this guideline. The current and anticipated future use of THGC, including the influence of the COVID‐19 pandemic, provides the context for this guideline. Recommendation: The Telehealth Practice Guideline author workgroup conditionally recommends telehealth genetic counseling, either via telephone or video, as a delivery method for genetic counseling. Depending on factors unique to individual healthcare systems and provider and patient populations, THGC may be the only service delivery model available or may be utilized in addition to other service delivery models including in‐person genetic counseling. The evidence shows large desirable effects, minor undesirable effects, and increased equity for patients when THGC is available. THGC may reduce or remove existing barriers to patient access to genetic counseling, such as medical conditions and/or disabilities that may affect a patient's ability to travel, inflexible work or school schedules, and lack of reliable transportation, finances, or dependent care. THGC is likely acceptable to key groups impacted by its use and is feasible to implement. Certain patient populations may require additional resources or encounter more barriers in using telemedicine services in general. For these populations, THGC can still be a valuable option if solutions are available.