Miracle-dz/UniFAR-FTUs huggingface dataset:
Measures of insulin sensitivity, leptin, and adiponectin concentrations in cats in diabetic remission compared to healthy control cats

Objectives Firstly, to compare differences in insulin, adiponectin, leptin, and measures of insulin sensitivity between diabetic cats in remission and healthy control cats, and determine whether these are predictors of diabetic relapse. Secondly, to determine if these hormones are associated with serum metabolites known to differ between groups. Thirdly, if any of the hormonal or identified metabolites are associated with measures of insulin sensitivity. Animals Twenty cats in diabetic remission for a median of 101 days, and 21 healthy matched control cats. Methods A casual blood glucose measured on admission to the clinic. Following a 24 h fast, a fasted blood glucose was measured, and blood sample taken for hormone (i.e., insulin, leptin, and adiponectin) and untargeted metabolomic (GC-MS and LC-MS) analysis. A simplified IVGGT (1 g glucose/kg) was performed 3 h later. Cats were monitored for diabetes relapse for at least 9 months (270 days). Results Cats in diabetic remission had significantly higher serum glucose and insulin concentrations, and decreased insulin sensitivity as indicated by an increase in HOMA and decrease in QUICKI and Bennett indices. Leptin was significantly increased, but there was no difference in adiponectin (or body condition score). Several significant correlations were found between insulin sensitivity indices, leptin, and serum metabolites identified as significantly different between remission and control cats. No metabolites were significantly correlated with adiponectin. No predictors of relapse were identified in this study. Conclusion and clinical importance Insulin resistance, an underlying factor in diabetic cats, persists in diabetic remission. Cats in remission should be managed to avoid further exacerbating insulin resistance.
True Cost Accounting of a healthy and sustainable diet in Italy

It is widely upheld that global food systems are unsustainable. Sustainable diets are gaining prominence as key components to entangle global food system challenges, as well as to transition towards the pathway of the 2030 Agenda and the Sustainable Development Goals (SDGs). Hence, sustainable and healthy diets are at the core of much research with the aim to bring together nutritional adequacy, cultural acceptability, environmental sustainability, economic affordability, and shape future consumption patterns. This article contributes to advancing knowledge on sustainable diets by proposing a True Cost Accounting method to assess the cost and impact of the adoption of a more sustainable and healthier diet, using Italy as an illustration. The research analyses the complexity of a diet from an environmental, health, and socioeconomic point of view and defines a new assessment framework that can be replicated and adapted to other contexts. Results show that in Italy, the adoption of a sustainable and healthy diet has a 47% lower carbon footprint and 25% lower water footprint than the current diet, while impacting 13% less on the average income and food monthly expenditure. Also, the desirable diet has a 21% lower impact on the sanitary costs related to cardiovascular disease. This study corroborates that the consumption of the desirable diet would provide a total cost saving of 741 EUR per year per capita, if we consider its impact on the environment, health, and socio-economic costs.
O RIGINAL R EPORTS : P UBLIC H EALTH T HE I MPACT OF S OCIAL C OMMUNICATION ON P ERCEIVED HPV V ACCINE E FFECTIVENESS IN A L OW - INCOME , M INORITY P OPULATION

Objectives: Perceived vaccine effectiveness is linked to vaccine-uptake. This study aims to determine if hearing about the HPV vaccine from family/friends (social source) or discussing the vaccine with family/friends (social discussion) is associated with perceived HPV vaccine effectiveness among female ethnic-minority, medical-decision-makersof vaccine-eligible girls. Methods: Data come from a cross-sectional HPV vaccine telephone-survey administered by the Los Angeles County Office of Women’s Health (OWH) hotline operators between January-November 2009. Among survey par-ticipants who reported awareness of the HPV vaccine ( n 5 294), two logistic regression mod-els of perceived HPV vaccine effectiveness were conducted; a source of information model with social source as the main predictor, and a discussion model with social discussion as the main predictor. These were adjusted for medical source and medical discussion, and covariates affecting interaction with the health care system. Results: Women who heard about the HPV vaccine from a social source were more likely to perceive the vaccine as effective compared to those who did not report a social source of information (adjusted OR 4.78, 95% CI 1.76– 12.98). Medical source of information was also associated with perceived vaccine effectiveness (adjusted OR 2.07, 95% CI 1.06–4.05). Those who reported social discussion, but not those who discussed the vaccine with a medical provider, had increased odds of perceived vaccine effectiveness (adjusted OR 1.98, 95% CI 1.04–3.78). Conclusions: Social source of information and social discussion were associated with perceived HPV vaccine effectiveness; this high-lights the value of social communication among low-income minority women, and the need for vaccine-messaging interventions that utilize a social network approach. ( Ethn Dis. 2011;21(4):495–501)
How Parenting and Family Characteristics Predict the Use of Feeding Practices among Parents of Preschoolers: A Cross-Sectional Study in Beijing, China

Parental coercive and structured feeding practices are linked with children’s weight gain. Thus, identifying their predictors will assist in childhood obesity prevention. We explored how parents’ concerns and perceptions of children’s weight, parenting stress, parenting competence, parents’ family roles, and only child status (of both parent and child) predict the use of restriction, pressure to eat, and monitoring practices among parents of preschoolers. Parent–child dyads (n = 2990) were recruited in Beijing in 2019. Parenting competence, parents’ weight perceptions and feeding practices were assessed using the Chinese version of Parenting Sense of Competence Scale and Child Feeding Questionnaire (CFQ), respectively. Parenting stress and other variables were collected through self-administered questionnaires. Multivariate linear associations between parents’ weight perceptions and feeding practices were significant among normal-weight children. Parents’ concerns about children being overweight were positively associated with restriction and monitoring, and negatively associated with pressure to eat. Higher levels of parenting stress and parenting competence significantly improved the adoption of restriction and pressure to eat. Parents’ only child status and that of children had an impact on parents’ feeding practices. The fathers’ feeding preferences were substantially different from what mothers preferred. In conclusion, such parenting and family characteristics significantly influenced feeding practices of preschoolers’ parents. These were long neglected in China.
CCIDE_A_369481 217..223

Aim: To determine the impact of recurrent aphthous stomatitis on quality of life related to oral health, and then to determine the relationship between the observed impact and lesions characteristics. Methods: In this prospective case-control study (n=62), patients were divided into a healthy group (people with no history of ulcers) and recurrent aphthous stomatitis (people who had an active ulcer at study entry). The latter were also evaluated when the lesion disappeared (remission stage). We record the quality of life in all groups using the impact profile of oral health in its abbreviated Spanish version (OHIP-14SP). Finally, we correlate the clinical characteristics of the lesions with the levels of quality of life. Results: All the lesions were of the minor morphological type. Most of the lesions were located on the lining mucosa, primarily on the lips. Patients report a lower quality of life during ulcer episodes compared to ulcer-free periods, and this impact is positively related to the number and size of lesions. Conclusion: We concluded that recurrent aphthous stomatitis increased the negative effects of oral health on the quality of life of patients. The number and size of ulcers are responsible for this impact. Our results suggest that, if intervened locally, general relief of the condition could be achieved.
Molecular evaluation of prepared Rift Valley Fever (RVF) vaccine using Montanide Gel 02 and its effect on the genetic material

Rift Valley fever (RVF) is a zoonotic, arthropod-borne viral disease that affects domestic animals. The disease is caused by the Rift Valley fever virus (Phlebovirus) that belongs to the Phenuiviridae family. Rift Valley fever (RVF) is an animal origin viral bleeding disease that affects the health of both humans and animals because it’s a Phlebovirus that makes it very dangerous. Conventional technologies were used to develop the first vaccines, such as inactivated vaccines and the live-attenuated Smithburn vaccine, using virulent RVF virus isolates. Various vaccines against the RVF virus have been developed, the modern trends in vaccine production are going to choose. The adjuvant used in the vaccine production process is a significant consideration. Therefore, in this study we explored the use of Maintained gel 0.2 as adjuvant. The proper adjuvant that can appear high and long-standing immunity. Maintained gel 0.2 is generic of maintaining as water-based adjuvant designed recently to improve efficacy of aqueous type vaccine. Therefore, we investigated the effect of inactivated RVF vaccine with three different concentrations of Montanide Gel 02 (10%, 15% and 20%). The immune response was evaluated and evaluated of the immune response in vaccinated rabbits using real time PCR (RT-PCR). Also, and in other side, starting coding target (SCOT) technique was were used to study the genetic effect of the vaccine on the rabbit’s genetic material. RT-PCR The real time PCR results for interferon γ showed that there was dramatically upregulation in transcripts levels of interferon γ with the increases of Montanide gel doses throughout the whole entire period of the experiment. A total of 10 primers were tested for selective amplification of DNA fragments. The ten SCoT primers produced reliable PCR products. However, no SCoT primers showed discernible polymorphism between all tested samples. However, no Scot primers showed discernible polymorphism between all tested samples. The study revealed that with increasing Montanide gel 02 concentration in the rabbit's vaccination, the immune response and its duration increased, with no influence on the genetic material, indicating that Montanide gel 02 was safe and effective. The immune response and its duration were increased with increasing Montanide gel 02 concentration in the rabbit's vaccination, and there was no effect on the genetic material, which gives is give an indication that Montanide gel 02 was safe and effective.
Current perspective on eicosanoids in and allergic diseases - EAACI Task Force consensus report, part

Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes, 53 thromboxanes and lipoxins, involved in several pathophysiological processes relevant to 54 asthma, allergies and allied diseases. Prostaglandins and leukotrienes are the most studied 55 eicosanoids and established inducers of airway pathophysiology including bronchoconstriction 56 and airway inflammation. Drugs inhibiting the synthesis of lipid mediators or their effects, such 57 as leukotriene synthesis inhibitors, leukotriene receptors antagonists, and more recently 58 prostaglandin D 2 receptor antagonists, have been shown to modulate features of asthma and 59 allergic diseases. This review, produced by an European Academy of Allergy and Clinical 60 Immunology (EAACI) task force, highlights our current understanding of eicosanoid biology 61 and its role in mediating human pathology, with a focus on new findings relevant for clinical 62 practice, development of novel therapeutics, and future research opportunities.
Types of prediction: from basic expectations to preactivation of specific features

There is currently much interest in the role of prediction in language processing, both in L1 and L2. For language acquisition researchers, this has prompted debate on the role that predictive processing may play in both L1 and L2 language learning, if any. In this conceptual review, we explore the role of prediction and prediction error as a potential learning aid. We examine different proposed prediction mechanisms and the empirical evidence for them, alongside the factors constraining prediction for both L1 and L2 speakers. We then review the evidence on the role of prediction in learning languages. We report computational modelling which underpins a number of proposals on the role of prediction in L1 and L2 learning, then lay out the empirical evidence supporting the predictions made by modelling, from research into priming and adaptation. Finally, we point out the limitations of these mechanisms in both L1 and L2 speakers.
Parallel duplication and loss of aquaporin‐coding genes during the “out of the sea” transition as potential key drivers of animal terrestrialization

One of the most important physiological challenges animals had to overcome during terrestrialization (i.e., the transition from sea to land) was water loss, which alters their osmotic and hydric homeostasis. Aquaporins are a superfamily of membrane water transporters heavily involved in osmoregulatory processes. Their diversity and evolutionary dynamics in most animal lineages remain unknown, hampering our understanding of their role in marine–terrestrial transitions. Here, we interrogated aquaporin gene repertoire evolution across the main terrestrial animal lineages. We annotated aquaporin‐coding genes in genomic data from 458 species from seven animal phyla where terrestrialization episodes occurred. We then explored aquaporin gene evolutionary dynamics to assess differences between terrestrial and aquatic species through phylogenomics and phylogenetic comparative methods. Our results revealed parallel aquaporin‐coding gene duplications during the ecological transition from marine to nonmarine environments (e.g., brackish, freshwater and terrestrial), rather than from aquatic to terrestrial ones, with some notable duplications in ancient lineages. In contrast, we also recovered a significantly lower number of superaquaporin genes in terrestrial arthropods, suggesting that more efficient oxygen homeostasis in land arthropods might be linked to a reduction in this type of aquaporin. Our results thus indicate that aquaporin‐coding gene duplication and loss might have been one of the key steps towards the evolution of osmoregulation across animals, facilitating the “out of the sea” transition and ultimately the colonization of land.
Social Assistance Expenditure as Mediating in Regional Original Income, General Allocation Funds, Against the Number of Poor People

– This research is motivated by the high level of poverty causing the costs to be incurred for economic growth to be greater, so that it can hamper the rate of economic growth. The purpose of the study was to determine the effect of Regional Original Income and General Allocation Funds on social assistance spending, the effect of Regional Original Income and General Allocation Funds on the number of poor people, and whether social assistance expenditures were able to mediate the relationship between Regional Original Income and General Allocation Funds on the number of poor people. The population is 122 regencies/cities on the islands of Java and Bali, and the sample is taken by a purposive sampling method. The test methodology makes use of path analysis. The results of the study show that Regional Original Income has an effect on social assistance spending, General Allocation Funds have no effect on social assistance spending, Regional Original Income does not affect the number of poor people, the General Allocation Funds affect the number of poor people, and social assistance spending can mediate the relationship between income Regional Original Income on the number of poor people and spending on social assistance cannot mediate the relationship between the General Allocation Fund and the number of poor people on the islands of Java and Bali in 2016-2018. The ability of the variables of Regional Original Income, General Allocation Funds, and Social Assistance Expenditures to explains the variable of Number of Poor People by 43.5%. While the remaining 56.5% is influenced by other factors not examined.
The effectiveness of chitosan in increasing immunity against Aeromonas hydrophila in sangkuriang catfish ( Clarias gariepinus ) Efektivitas kitosan dalam meningkatkan immunitas terhadap Aeromonas hydrophila pada ikan lele sangkuriang ( Clarias gariepinus )

The purpose of this research is to find out the optimal dose of chitosan that is appropriate to be added to commercial feed in increasing the immune system of sangkuriang catfish fry, the fish fry used are 6-8 cm in size. April – June 2021 was the time the research was carried out and the experimental method used in this study was a Completely Randomized Design (CRD) with five treatments and three replications. The treatment used was the addition of chitosan to 1 kg of feed with doses of 0 g (A), 2.5 g (B), 5 g (C), 7.5 g (D), and 10 g (E). Maintenance of test fish for 14 days. Aeromonas hydrophila bacteria were used to infect fish with a density of 108 CFU/ml by immersing 20 ml in 20 liters of water for 14 days. White blood cells, leukocyte differential, clinical symptoms in fish body, survival rate and water quality were used as parameters in this research. The results showed that the addition of chitosan at a dose of 10 g (E) per 1 kg of feed was effective for improving the immune system performance of catfish fry. During 14 days of chitosan administration, the number of white blood cells in treatments A, B, C, and D increased by 3.2%, 7.07%, 18.31%, and 27.71%, respectively, while in treatment E (10 g) experienced the largest increase with 41.60%, from the value of 13.96 × 104 cells/mm3 to 23.90 × 104 cells/mm3. The treatment of chitosan 10 g (E) per 1 kg of feed showed the largest increase so it was an effective dose to stimulate differential leukocytes of catfish to improve the immune system, it was also marked by the fastest healing period of clinical symptoms and after the challenge test had the highest survival rate of 96.6%.
NSS_A_361318 1333..1340

1North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; 2Division of Immunology, Immunity to Infection and Respiratory Medicine, University of Manchester, Manchester, UK; 3Center for Research and Innovation in Precision Medicine of Respiratory Diseases, Department of Pulmonology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 4Department of Neurology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 5Department of Cardiology (II), “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 6Department of Clinical Research, Institute of Cardiovascular Diseases, Timisoara, Romania; 7Second Department of Internal Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 8Department of Anatomy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania
Type 1 piliated uropathogenic Escherichia coli hijack the host 1 immune response by binding to CD 14 2 3

14 A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to 15 evade the host’s immune response. Many Enterobacteriaceae express type 1 pili, a pre16 adapted virulence trait, to invade host epithelial cells and establish persistent infections. 17 However, the molecular mechanisms and strategies by which bacteria actively circumvent 18 the immune response of the host remain poorly understood. Here, we identified CD14, the 19 major co-receptor for lipopolysaccharide detection, on mouse dendritic cells as a binding 20 partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli. The 21 FimH amino acids involved in CD14 binding are highly conserved across pathogenic and 22 non-pathogenic strains. Binding of the pathogenic strain CFT073 to CD14 reduced dendritic 23 cell migration by overactivation of integrins and blunted expression of co-stimulatory 24 molecules by overactivating the NFAT pathway, both rate-limiting factors of T cell activation. 25 This response was binary at the single cell level, but averaged in larger populations exposed 26 to both piliated and non-piliated pathogens, presumably via the exchange of 27 immunomodulatory cytokines. While defining an active molecular mechanism of immune 28 evasion by pathogens, the interaction between FimH and CD14 represents a potential target 29 to interfere with persistent and recurrent infections, such as urinary tract infections or 30 Crohn’s disease. 31
HPTD-M for Public Management Sustainability: A Proposal for Brazil

T his paper aims to study Brazilian public management through the HPTD-M theory (Holopraxis Transdisciplinary Management). The excess of analysis, bureaucracy, and rationality is a Brazilian bottleneck. The concept of transdisciplinarity is abbreviated in this article as TD. The HPTD-M approach is based on the principles of duality, i.e., interaction and integration of opposites, especially the analytical and synthetic methods, and four requirements, namely rationality, feasibility, reasonableness, and meaning. Complexity can be transformed into simplicity through deep studies and discussions with all actors involved. The methodology to achieve the four requirements comes from Jungian psychological functions: sensation, feeling, thinking, and intuition, respectively, which are translated into four skills or types of intelligence, namely empirical, emotional, rational, and intuitive. Our Findings involve dialectics as a sustainable duality required to improve the managerial aspects of the public organizations in Brazil: The dialogue between specialists and generalists, analytical and synthetic methods, academics and executives, technicians and managers, and techno-bureaucrats and politicians, through education and change in legislation. In this context, four major groups of disciplines: technoscience = technology + science; bureaucracy, which covers law and legislation; psychology, which includes the behavior of all actors in public administration and their relationship; and politics, which involves dialogue and complete information to subsidize higher instances decision, as opposed to political ideology or dogmatism. The HPTD-M applied to sustainable public management is simple, as a result of the sophistication of complexity through studies and discussions. In that sense, simplicity can be considered a requirement in public administration, owing to dialectic models for solving the complexity of human phenomena. These HPTD-M concepts can hopefully help other open systems of knowledge as well, such as in sciences, economics, law, psychology, and politics. New approaches for governance and internal sustainability could emerge in other countries with similar problems of bureaucracy, with direct implications for the quality of public expenditure. duality, to a presence of and bureaucratic fails to the four into the