Miracle-dz/UniFAR-FTUs huggingface dataset:
Statement on the Safety of Biological Treatments with Monoclonal Antibodies and Fusion Proteins : An Update

Objective: The introduction of biological drugs, including monoclonal antibodies and fusion proteins, into therapeutics is among the greatest achievements of modern medicine. These agents have been successfully used in oncology, haematology, rheumatology, gastroenterology, ophthalmology, dermatology, and allergology. Herein, we present a consensus of expert opinion regarding biologics use as an update to the Expert Group Position Statement published in 2014. Considering the rapid development within this field and the evidence accumulated in the last few years with the use of innovative biologics and biosimilars, an update has become necessary. The importance of real-world evidence from observational studies and medical registries and the way it complements data from randomised studies will be highlighted. Therefore, the expert opinion regarding switching between bio-originator and biosimilar therapeutics, immunogenicity, pharmacovigilance, and the costs of biological treatments is constantly in f lux. Methods: An expert panel of national consultants, members of the coordination teams of Polish drug programs, and specialists with expertise in biological treatments participated in this study in order to establish a consensus on the most critical aspects of biological treatment in Poland. A modified Delphi method was performed to achieve a consensus on relevant statements, which was met if at least 80% of experts agreed or disagreed with the discussed statement. Results: The current expert position on the use of biosimilars in everyday practice was thoroughly investigated. For nine of the presented statements, panellists agreed that the expected cost savings due to biosimilars introduction, safety of extrapolation of indications, single switching bio-originator and biosimilar. Moreover, the overall access to biological treatment in Poland was explored. Conclusion: The present analysis will serve as a guide to physicians that prescribe biological treatments to aid them in the critical analysis on the use of biosimilars and will further support treatment decisions and patient education on the subject.
The Relationship between Health Literacy and Physical Activity Level of Elderly Women in the City of Urmia

Background and objective: Health Literacy refers to cognitive and social skills which determine the motivation and knowledge intended for people to obtain information and access to understand and using them to promote and keeping fitness. Regular physical activity is necessary for human. The purpose of this study was to investigate the relationship between Health Literacy and physical activity level of elderly women in the of Urmia city. Methods: In this descriptive n correlation study of 120 elderly women of Urmia were selected. In Order to collect data, two questionnaire Functional Health Literacy of TOFHLA adultsnn and a physical activity questionnaire of Baekce was used. It was used SPSS software and one-sample T- test, and it was also conducted Pearson correlation and stepwise regression. Results: of 30 of the elderly had adequate Health Literacy 38/34 had inadequate health literacy and 31/64 had cross-border Health Literacy. Correlations were positive and significant correlation between adequate Health Literacy and physical activity were cross-border health physical activity in respectively. One-sample T-Tak results showed that the level Health Literacy in both access and reading in elderly women is higher than the average level in Urmia. Stepwise regression analysis showed that adequate health and cross-border Health Literacy can account for more than 80 percent of their sporting activities. Conclusion:n In order to promote physical activity levels of elderly women it should be improved their health literacy. By planning and designing useful training in the field of Health Literacy programs tailored to the elderly it can be done effective step to develop literacy skills in community health and physical health of elderly. Paper Type: Research Article
Follicular and luteal dynamics of dairy buffaloes that were treated or not with prostaglandin at the beginning of the synchronization protocol for TAI

The study aimed to evaluate the follicular and luteal development in buffaloes submitted to a TAI protocol according to the presence or absence of a functional corpus luteum during the maintenance of Progesterone intravaginal device (P4). For this, 26 multiparous Murrah buffaloes in milk, bred in a farm located in Registro, State of Sao Paulo were used. Before the TAI protocol, all buffaloes were subjected to a pre-synchronization protocol, which consisted two doses of 0.53 mg of PGF2α im (Cloprostenol, Sincrocio®, Ourofino Agribusiness), on days -24 and -12, in order to produce a corpus luteum (CL) functional at the time of initiation of the TAI protocol (D0). On D0 (4:00h PM), the buffaloes received a new P4 intravaginal device (1g progesterone; Sincrogest®, Ourofino Agrobusiness) plus 2.0 mg of estradiol benzoate im (Sincrodiol®, Ourofino Agrobusiness). At this time (D0), the 26 buffaloes were randomly assigned to two treatments: 12 animals received one dose of PGF2α (PGF group) to keep the intravaginal device as their only source of P4; while the other 14 females remained without the PGF2α administration (Control group), which maintained a CL during treatment in addition to P4 intravaginal device. On D9 (04:00h PM), females received 0.53 mg of PGF2α im (Cloprostenol, Sincrocio®, Ourofino Agrobusiness), followed by removal of the progesterone device. On D10 (04:00h PM) 1.0 mg of estradiol benzoate (Sincrodiol®, Ourofino Agrobusiness) was administered im. Ultrasound assessments (Chison D600Vet, China) were performed to determine: the presence of CL on D0, D3, D6 and D9; and diameter of the dominant follicle in D3, D6, D9 and D12 (oDF); Ovulation rate (Ov. rate); The daily growth rate of the dominant follicle was calculated by the difference between the observed measures, and then dividing by the number of days apart (mm/day). The comparison between the response variables was performed through analysis of variance (ANOVA) using the procedure Glimmix of SAS®. Difference was considered when P < 0.05. We observed the presence of CL in 100% of animals at the beginning of the TAI protocol (D0), with CL regression all animals in the PGF2α group. The results observed for the Control and PGF2α groups were, respectively: oDF D3, 3.1±0.2 vs. 3.2±0.4 mm (P=0.83); oDF D6, 5.6±0.4 vs. 6.5±0.8 mm (P=0.34); oDF D9, 6.9±0.5 vs. 9.3±0.8 (P=0.01); oDF D12, 8.3±0.9 vs. 10.6±1.0 (P=0.10); Ov. rate 42.9% vs. 66.7% (P=0,24) daily growth rate between D3 and D9 DF - 0.6±0.1 vs. 1.1±0.1 mm/day (P < 0.01); and daily growth rate of the DF between D9 and D12 - 0.7±0.3 vs. 0.9±0.3 mm/day (P=0.65). It was concluded that the presence of CL during the treatment with P4 intravaginal device reduce the development of the dominant follicle. However, after removing the progesterone intravaginal device no difference was observed between the groups for daily growth rate, diameter of the dominant follicle at the end of the treatment and ovulation rate.
Chemical Changes of Shredded Catfish (Clarias gariepinus) Added with Different Concentration of Sucrose During Storage at Room Temperature

Shredded catfish is a processed dried food, usually used as a side dish and stored for a long time. The main criteria of shredded fish selection is its taste, color and appearance. During storage, shredded catfish might be experienced deterioration in quality. Therefore, the purpose of this study was to determine changes in the chemical quality of shredded catfish with different sucrose concentrations during storage. The study was carried out by adding sucrose to the formulation of shredded catfish respectively 27.5%, 32.5%, and 37.5%. For a comparison purposed, commercial shredded catfish with sucrose addition of 35% was applied. All samples were stored for 60 days and observed every 30 days for the moisture content, aw, color measurement, peroxide value (PV), thiobarbituric acid (TBA), free fatty acid (FFA) and fatty acid profile. The results show that during storage at room temperature shredded catfish with 27.5% sucrose was the best quality product. During storage there was an increase in moisture content, aw, TBA and FFA, while for PV parameters increased in fluctuation at day 30 of storage and decreased at day 60 of storage. Color parameter decreased from dark to slightly bright and unsaturated fatty acids decreased in oleic, linoleic, linolenic and DHA. Based on these results, shredded catfish still safe to be consumed during storage for 60 days or two months.
Dual pathways of emotional competence towards incremental and radical creativity: resource caravans through feedback-seeking frequency and breadth

ABSTRACT This study examined how employees’ emotional competence predicts feedback-seeking behaviour (FSB) and consequently incremental and radical creativity on the basis of conservation of resource (COR) theory. We posit that emotional competence enhances the two types of creativity by generating resource caravans through distinct patterns of FSB. Our analysis based on the data collected from 206 employees from 85 work teams revealed that emotional competence has a significant indirect effect on the incremental creativity of team members, as rated by leaders, through frequent feedback seeking. Emotional competence also exhibited a considerable direct effect on radical creativity. In addition, emotional competence predicted source variety, namely, feedback-seeking breadth, which in turn contributed to radical creativity. This study offers new and useful theoretical and practical insights regarding the different types of creativity in the workplace by employing COR theory and the resource caravan perspective.
Eating Disorders in Males: A Case Series Study to Evaluate Putative Risk Factors

This case series aimed to describe the clinical features and symptomatic onset of eating disorders (EDs), to characterize male puberty development and to identify potential risk factors (RFs) for EDs and specific life events preceding ED symptoms. Ten males with current ED diagnoses participated in this study. All participants were interviewed with the Eating Disorders Examination, the Oxford Risk Factor Interview, and a semi-structured clinical interview for the evaluation of males’ puberty development. Almost all participants began their EDs with dieting. Half of the participants mentioned the development of muscle mass and experiences of embarrassment related to undressing in front of their peers. A history of peer aggression and/or teasing was the only RF experienced by all the participants.
Hepatitis B virus remains the leading cause of cirrhosis of liver in Bangladesh

Cirrhosis is a serious and irreversible disease. It is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrotic scar tissue as well as regenerative nodules, leading to progressive loss of liver function. Present study was conducted to evaluate the aetiological factors of liver cirrhosis. This was a retrospective cross-sectional study. Patients attending Hepatology Green Unit, Bangabandhu Sheikh Mujib Medical University, Dhaka in 2014 with cirrhosis were included. Total 770 patients were studied, 525(68.18%) males and 245(31.82 %) females. Majority of patients, 379(49.22%) had HBV infection, 162(21.04%) had NASH, 113(14.68%) had HCV infection, 31(4.02%) had alcohol abuse, 28(3.64%) had Wilson’s disease , 23(2.98%) had autoimmune hepatitis and no etiological factors (cryptogenic) were recorded in 34 (4.42%) patients. HBV infection was the major risk factor for cirrhosis in our patients. Bangladesh Med J. 2016 Sep; 45 (3): 164-166
Moho depth of the British Isles: a probabilistic perspective

We present a new Moho depth model of the British Isles and surrounding areas from the most up-to-date compilation of Moho depth estimates obtained from refraction, reflection and receiver function data. We use a probabilistic, trans-dimensional and hierarchical approach for the surface reconstruction of Moho topography. This fully data-driven approach allows for adaptive parametrization, assessment of relative importance between different data-types and uncertainties quantification on the reconstructed surface. Our results confirm the first order features of the Moho topography obtained in previous work such as deeper Moho (29–36 km) in continental areas (e.g. Ireland and Great Britain) and shallower Moho (12–22 km) offshore (e.g. in the Atlantic Ocean, west of Ireland). Resolution is improved by including recent available data, especially around the Porcupine Basin, onshore Ireland and Great Britain. NE trending features in Moho topography are highlighted above the Rockall High (about 28 km) and the Rockall Trough (with a NE directed deepening from 12 to about 20 km). A perpendicular SE oriented feature (Moho depth 26–28 km) is located between the Orkney and the Shetland, extending further SW in the North Sea. Onshore, our results highlight the crustal thinning towards the N in Ireland and an E–W oriented transition between deep (34 km) and shallow (about 28 km) Moho in Scotland. Our probabilistic results are compared with previous models showing overall differences around ±2 km, within the posterior uncertainties calculated with our approach. Bigger differences are located where different data are used between models or in less constrained areas where posterior uncertainties are high.
Neonatal sepsis: Highlighting the principles of diagnosis and management

Neonatal sepsis is a clinical syndrome consisting of nonspecific symptoms and signs of infection, accompanied by a bacteraemia in the first 28 days of life. The risk of neonatal sepsis and death increases with decreasing birth weight and gestational age. South African data have reported the overall incidence of neonatal sepsis to be 8.5 - 10%, with late-onset sepsis accounting for most of these infections. The diagnosis of neonatal sepsis is not always straightforward, and the initiation and continuation of antimicrobials in these situations relies on good clinical judgment. The need for empirical antimicrobials is driven by the existence of risk factors for early-onset sepsis and clinical symptoms and signs of late-onset sepsis. Antimicrobial stewardship programmes should be in place to guide clinicians to either stop, change, or continue antimicrobials. Institution-specific knowledge of the most common pathogens and the antimicrobial susceptibility pattern is important to prevent the emergence of further antimicrobial resistance.
Thrown into the world: The shift between pavlova and pasta in the ethnic identity of Australians originating from Italy

Forty-one years on from Huber’s study exploring the assimilation of Italian-Australians, an increasing trend towards ethnic revival can be observed among the third generation of immigrants. Drawing on a case study of a family originating from Calabria in the 1950s and now living in Adelaide, South Australia, I find a widespread intergenerational identification of ethnicity as ‘being Italian’, which has different meanings across the three generations, depending on the individual’s phenomenological perception of being thrown into the world. A pivotal role in this shift of ethnic identity is played by what I refer to as institutional positionality, the individuals’ perceptions of the position of their ethnic ‘being in the world’. By merging sociology of migration, including the Bourdieusian conceptual apparatus of capital, with Heidegger’s existential theory, a reflexive framework is developed that takes into account the relevance of ontology in the field of migration.
Readdressing the role of therapeutic drug monitoring for antiepileptic drugs – A tertiary care hospital experience

Background: Therapeutic drug monitoring is a beneficial tool to supervise patients when they do not respond to a therapeutic dose. Inter individual variability in the concentration of an antiepileptic drug that produces optimal therapeutic response is highly significant. Therefore, this retrospective study was taken up to study the inter relation between antiepileptic drug dosages, serum concentration sand clinical condition in the Indian patients. Materials and Methods: This is a retrospective study, in which the data of the samples of adult patients of either gender, analyzed for Phenytoin, Valproate, Carbamazepine and Phenobarbitone were included. The samples were stratified based on dosage prescribed. The endpoints were to estimate the percentage of samples of each stratum having sub therapeutic, therapeutic and supra therapeutic concentrations. Results: Of the 134 samples included, 114 (85%) were analyzed for phenytoin, 9 for valproate, 7 for carbamazepine and 4 for phenobarbitone. Of the 114 samples analyzed for phenytoin, 61(53.5%) samples were having sub therapeutic concentrations, 22 samples (19.3%) had therapeutic concentrations and 31 samples (27.2%) had toxic concentrations. Among the 61 samples having sub therapeutic concentrations, 54.1% were prescribed dose of 300-350mg/day, 16.4% were on 350-400 mg/day and 1.6% were taking above 400mg/day. Of the total cases referred, 41.8 % had H/O of seizures and 30.6% presented with toxic symptoms. Conclusion: This study demonstrated unpredictable inter individual variability in clinical response based on reference ranges. However, the relevance of individual reference concentrations for predicting outcomes can only be confirmed through adequately controlled randomized studies.
Holocene climate recorded by magnetic properties of lake sediments in the Northern Rocky Mountains, USA

We present two hypotheses regarding the evolution of Holocene climate in the Northern Rocky Mountains that stem from a previously unpublished environmental magnetic record from Jones Lake, Montana. First, we link two distinct intervals of fining magnetic grain size (documented by an increasing ratio of anhysteretic to isothermal remanent magnetization) to the authigenic production of magnetic minerals in Jones Lake bottom waters. We propose that authigenesis in Jones Lake is limited by rates of groundwater recharge and ultimately regional hydroclimate. Second, at ~8.3 ka, magnetic grain size increases sharply, accompanied by a drop in concentration of magnetic minerals, suggesting a rapid termination of magnetic mineral authigenesis that is coeval with widespread effects of the 8.2 ka event in the North Atlantic. This association suggests a hydroclimatic response to the 8.2 ka event in the Northern Rockies that to our knowledge is not well documented. These preliminary hypotheses present compelling new ideas that we hope will both highlight the sensitivity of magnetic properties to record climate variability and attract more work by future research into aridity, hydrochemical response, and climate dynamics in the Northern Rockies.
Fatores preditores da sobrecarga subjetiva de familiares de pacientes psiquiátricos atendidos na rede pública de Belo Horizonte

This study investigated the factors predictors of subjective burden of family of psychiatric patients. We interviewed 150 relatives of patients randomly selected in four mental health services of Belo Horizonte, Minas Gerais State, Brazil. Subjects were interviewed with the Family Burden Interview Schedule (FBIS-BR) and a standardized socio-demographic data questionnaire. Variables were grouped into thematic categories and separated submited to analyses to determine the relative importance of factors predictors. The results showed that subjective burden is influenced by objective burden and by factors related the patient’s clinical conditions, the caregivers’ life, health conditions, financial situation of caregiver and patient and increased demand for information about mental illness. Subjective burden was decreased when the caregivers had religious activities and leisure, admitting publicly be caregiver of a psychiatric patient and having positive feelings toward the patient. The results pointed the need to include monitoring family in the community model of psychiatric care. Mentally Ill Persons; Caregivers; Family Introducao
Secondary Trauma Issues for Psychiatrists: Identifying Vicarious Trauma and Job Burnout

alization of vicarious trauma was developed from analytical models that incorporate the broader conceptualization of compassion fatigue in the clinical literature. For this project, we assessed a random sample of senior-level social workers in New York City following the 9/11 attacks. With the inclusion of PTSD in DSM-III, stress response symptoms related to psychological trauma have been defined as a psychiatric disorder. The concept of compassion fatigue emerged when clinicians noted the occupational effects among mental health workers who work with traumatized patients. In essence, some professionals appeared to experience the effects of their client’s trauma vicariously. It seemed that vicarious trauma was a risk factor for mental health professionals who were exposed to significant numbers by Joseph A. Boscarino, PhD, MPH, Richard E. Adams, PhD, and Charles R. Figley, PhD
Use of Intravenous Omeprazole in a University Hospital

Objective: To evaluate the characteristics of using intravenous omeprazole in a university hospital. Method: A prospective follow-up of all patients (n = 108) treated with intravenous omeprazole in our hospital was done from October 1994 through May 1995. Based on requests sent to the pharmacy service, patients receiving this drug were located and their charts were reviewed. The patients were visited daily throughout the duration of their treatment to evaluate any change in dosage, addition of new drugs to the regimen, and the final date of treatment. Results: Only 52% of the patients received omeprazole for indications in which its usefulness is clearly demonstrated. The dosages used frequently exceeded those recommended by the pharmaceutical manufacturer and in the literature. In fact, more than 50% of the patients were treated with dosages over 40 mg/d. It would have been possible to administer omeprazole orally instead of intravenously in 17% of the patients. Twenty-three percent of the patients were treated simultaneously with omeprazole and histamine2-antagonists. Conclusions: The use of intravenous omeprazole in our hospital is not optimal; thus, it seems that a strategy to improve this situation should be designed.