Miracle-dz/UniFAR-FTUs huggingface dataset:
The Potential Ameliorative Effects of Annona muricata (Linn) on Sodium Fluoride-Induced Toxicity on Haematological Indices and Fecundity of Adult Male Wistar Rats

Aim: Ameliorative potentials of Annona muricata (Linn) on Sodium fluoride-induced toxicity on haematology indices and fecundity of adult male Wistar rats. Methods: Eighty-five (85) adult male Wistar rats were divided into 17 groups of 5 rats each. NaF (10 mg/kg) + fruit juice, simultaneous decrease in dead spermatozoa as compared to the rats of the group treated with NaF alone. Result also showed that treatment with doses above 500 mg/kg body weight of NaF + fruit juice, NaF + stem bark and leaf extracts produced significant increases (p<0.05) in Hb concentration and PCV when compared with group 2 rats. Similarly, groups treated with NaF + 2000 mg/kg of fruit juice and NaF + 1000 mg/kg of stem bark, and leaf extracts, showed a significant increase (p<0.05) in platelet count when compared with groups 1 and 2 rats. Histological examination showed that NaF treatment brought about severe testicular damage while treatment with the extracts ameliorated this effect. Conclusion: A. muricata fruit juice and extracts were found to increase testosterone concentration, thus validating its ameliorative potential in NaF-induced toxicity.
Modulation of Physiologic Parameters in Molted Isa Brown Laying-Hens by Glutamine + Glutamic Acid Supplementation

Feed costs are the main limiting factors in poultry industry and alternative sources of food and/or feed supplements to optimize the bird ́s life cycle and to extend their production period need to be explored. This study evaluated morphometric parameters of the small intestine and gonadotropin transcript levels in Isa Brown laying hens supplemented with glutamine + glutamic acid (Aminogut®) during a second production cycle. Molting was induced and groups of 100 hens each, were supplemented with 0, 0.8, 1.6 or 2.4% Aminogut® in their diet. At the end of the experimental period, tissue sections from duodenum, jejunum and ileum were processed by the HematoxylinEosin technique and samples from hypothalamus and hypophysis were collected for RT-PCR analysis of GnRH and GnRHR transcript levels. As results, the height of the intestinal villi of the duodenum and ileum was significantly (p<0.05) higher in hens supplemented with 0.8% and 1.6% Aminogut®, while in the jejunum, no significant differences were found. Hens treated with increased doses of Aminogut® tended to increase GnRH transcripts levels, whereas those of GnRHR tended to decrease proportionally. It is concluded that supplementation of Isa Brown laying hens during a second production cycle with Aminogut® developed increased villus height in duodenum and ileum that may promote better absorption of nutrients and potentially to increase the egg production. This study shows the importance of molecular techniques such as RT-PCR to support the biological effects of nutritional compounds on morphological parameters and hen productivity.
More Robust and Reliable Optimized Energy Conversion Facilitated through Electric Machines, Power Electronics and Drives, and Their Control: State-of-the-Art and Trends

According to the special section entitled ‘Robust design and analysis of electric machines and drives’, to be published in IEEE Transactions on Energy Conversion, the authors present an introduction to tolerance analysis, robust optimization, and measures to improve the reliability of electric machines, power electronics and drives, and their robust control in general. A comprehensive review of modeling uncertainties and evaluating robustness and reliability based measures is presented. In addition, techniques facilitating solving dedicated optimization scenarios are introduced. The most recent research activities will be illustrated. The article thus enables to easily catch up with the state-of-the-art in these fields and to take notice of ongoing and future work.
Removal of Pesticides from Water Using Hypercrosslinked Polymer Phases: Part 1 — Physical and Chemical Characterization of Adsorbents

The physical and chemical properties of hypercross linked polymers have been compared with a commercial grade activated carbon for the sorption of organic micropollutants from water. Surface area and pore size distribution were measured by nitrogen sorption and the data analysed using a modified form of the Horvath and Kawazoe method. Surface reactivity and functionality of polymers was measured by diffuse reflectance infrared spectroscopy, X-ray photoelectron spectroscopy, solid state nuclear magnetic resonance, direct titration, elemental and zeta potential analysis. Chemviron F-400 activated carbon has a large surface area and is microporous but contains a significant proportion of mesopores. The hypercrosslinked polymer phases identified in this work have high surface areas (800−1000m2 g−1) and contain predominantly micro and macropores but virtually no mesopores. Chemical analysis of the surface of the polymers has identified oxygen and nitrogen functionalities which will have an advantageous influence on the binding of polar and non-polar organic micropollutants.
Beyond the seed: structural basis for supplementary microRNA targeting

microRNAs (miRNA) guide Argonaute proteins to mRNAs targeted for repression. Target recognition occurs primarily through the miRNA seed region, composed of guide (g) nucleotides g2–g8. However, nucleotides beyond the seed are also important for some known miRNA-target interactions. Here, we report the structure of human Argonaute2 (Ago2) engaged with a target RNA recognized through both miRNA seed and supplementary (g13–g16) regions. Ago2 creates a “supplementary chamber” that accommodates up to 5 miRNA-target base pairs. Seed and supplementary chambers are adjacent to each other, and can be bridged by an unstructured target loop of 1–15 nucleotides. Opening of the supplementary chamber may be constrained by tension in the miRNA 3' tail as increases in miRNA length stabilize supplementary interactions. Contrary to previous reports, we demonstrate optimal supplementary interactions can increase target affinity >20-fold. These results provide a mechanism for extended miRNA-targeting, suggest a function for 3' isomiRs in tuning miRNA targeting specificity, and indicate that supplementary interactions may contribute more to target recognition than is widely appreciated.
Detecting spatial dynamics of range expansions with geo-referenced genomewide SNP data and the geographic spectrum of shared alleles

Uncovering the spatial dynamics of range expansions is a major goal in studies of historical demographic inference, with applications ranging from understanding the evolutionary origins of domesticated crops, epidemiology, invasive species, and understanding specieslevel responses to climate change. Following the surge in advances that make explicit use of the spatial distribution of genetic data from georeferenced SNP variants, we present a novel summary statistic vector, the geographic spectrum of shared alleles (GSSA). Using simulations of twodimensional serial expansion, we find that the information from the GSSA, summarized with Harpending’s Raggedness Index (RI), can accurately detect the spatial origins of a range expansion under serial founder models, even with sparse sampling of only ten individuals. When applying to SNP data from two species of the holarctic butterfly genus Lycaeides, the suggested origins of expansion are consistent with hindcasts obtained from ecological niche models (ENMs). These results demonstrate the GSSA to be a useful exploratory tool for generating hypotheses of range expansion with genomewide SNP data. Our simulation experiments suggest high performance even with sampling found in studies of nonmodel organisms (one sampled individual per location, no outgroup information, and only 5,000 SNP loci).
Correlation Between Highly Sensitive C-Reactive Protein Level in Cases of Preeclampsia with or without Intrauterine-Growth Restriction

Background: Preeclampsia is one of hypertensive disorder that affects 4% of pregnant women, the exact cause cannot be identified and it is one of the major causes of both maternal and fetal morbidity and mortality , also it puts a burden on perinatal outcome as prematurity and Intrauterine growth restriction.Continuous search for predictive markers of severe PE is important and can be used to target high risk women for effective preventive treatment. Aim of study : to evaluate Highly Sensitive C-Reactive Protein role used as predictive factor for severity of preeclampsia and whether it can be used to predict development of Intrauterine growth restriction. Patients and methods : this is a cross-sectional study includes 80 pregnant women with their age 18-35 years , their gestational age range between 32- 40 weeks , admitted to AL-Zahraa teaching hospital in Najaf, whose diagnosed as PE based on blood pressure measurement and proteinuria. Full history and clinical examination were performed, venous blood aspirated for each women for biochemical analysis, Liver functions tests, Renal function tests, Highly Sensitive C- Reactive Protein, and Doppler ultrasound. Results :The patients divided into those with mild PE and severe PE, with or without IUGR. No significant difference between the level of Highly Sensitive C-Reactive Protein and the severity of PE as p value was[0.779], but there is significant difference between the presence of IUGR and the level of Highly Sensitive C-Reactive Protein when it is≥ 2mg/L as the p value was[0.020]. Conclusion : We conclude that Highly Sensitive C-Reactive Protein is not significantly associated with the severity of Preeclampsia but associated with intra uterine growth restriction.
Modular dynamics of DNA co-methylation networks exposes the functional organization of colon cancer cells’ genome

Summary DNA methylation dynamics is intrinsically interconnected with processes underlying the malignant properties of cancer cells. By applying network-based approaches in two series of colorectal cancers we dissected the long-range co-methylation structure finding consistent patterns of compartmentalization in both normal and tumor tissues. Large transchromosomal modules showed unique regulatory signatures and coalesced into a structured network and allowing simple patient stratification. Normal-tumor comparison revealed substantial remodeling of specific modules and migration of subsets of co-methylating sites denoted by functional aggregates, pointing out potential sources of epigenetic and phenotypic variability. We conclude that DNA methylation dynamics architecture embodies interpretable information that can be used as a proxy of the drivers and the phenotypes of malignant transformation. Significance DNA methylation is a key epigenetic mark directly involved in genome organization and regulation. DNA methylation profiles are variable and are extensively altered in most cancers. We show that DNA methylation variability follows a transchromosomal modular dynamics in both normal and colon cancer cells. The reshaping of the DNA methylation variability network in tumorigenesis exposes genomic and functional associations and points out both the mechanisms and the phenotypes of individual tumors. This information may be used for patient stratification and identification of disrupted pathways and therapeutic targets. Highlights DNA methylation variability displays a modular architecture in normal and cancer. Coordinated transchromosomal variations supersede regional DNA methylation dynamics. Co-methylation network modularity evinces functional and structural features. Epigenetic rewiring can be used as patient stratifier.
Plagiodinium ballux sp. nov. (Dinophyceae), a deep (36 m) sand dwelling dinoflagellate from subtropical Japan

A new species of marine sand‐dwelling dinoflagellate, Plagiodinium ballux N. Yamada, Dawut, R. Terada & T. Horiguchi is described from a deep (36 m) seafloor off Takeshima Island, Kagoshima Prefecture, Japan in the subtropical region of the northwest Pacific. The species is thecate and superficially resembles species of Prorocentrum, but possesses an extremely small epitheca. The cell varies from ovoid to a rounded square, and is small (15.0–22.5 μm in length) and laterally compressed. The thecal plates are smooth and the thecal plate arrangement (Po, 1′, 0a, 5″, 5C, 2S, 5‴, 0p, 1″″) is similar to that of Plagiodinium belizeanum, the type species of the genus. Molecular phylogenetic analyses based on SSU rDNA and partial LSU rDNA reveal that the dinoflagellate is closely related to P. belizeanum, but it can be clearly distinguished by its size and cell shape. This suite of morphological and molecular differences leads to the conclusion that this deep benthic dinoflagellate represents a new species of the genus Plagiodinium.
Critical flow of saturated and subcooled water at high pressure. [PWR; BWR]

Critical flow rate measurements have been made with saturated and subcooled water to determine the effect of fluid enthalpy, flow geometry and size, and flow length. These tests were conducted by blowing down vessels from an initial fluid pressure of 1000 psia (6895 kN/m/sup 2/) with the discharging fluid temperature between 450 and 550 F (232 and 288 C). The results clearly demonstrate the influence of metastable and/or nonequilibrium, thermodynamic states for flow lengths less than about 5 in. (127 mm). Data for different diameter nozzles, from 0.5 to 3.0-in. (12.7 to 76.2 mm), are presented which suggest that the critical mass flux decreases with increasing diameter.
Physical Activity Interventions in School and their impact on Scholastic Performance

The school is the only arena where the vast majority of children and youth can be reached, and school programs have had better results for improving inhibitory control than any other approach. The aim was to present and discuss intervention effects of Physical Activity (PA) carried out in the classroom compared to motor skills and Physical Education (PE) interventions. Results from PA interventions in school are inconsistent, but PE interventions which include motor skills exercise seem to be the most promising. The main findings show that motor skills are a stronger predictor of scholastic performance than aerobic fitness. Aerobic exercise with a high level of physical exertion does not improve any cognitive function in children. Cognitive engagement in PA at a moderate level seems to be the most promising type of exercise. PA lessons do not seem to improve any executive function and classroom-based PA do not have a positive impact on scholastic performance. Although there is some evidence that a single session of moderate PA may improve cognitive performance among children, too intense levels of PA may blunt any beneficial effect. There is a lack of a theoretical basis as to why PA lessons may facilitate scholastic performance. What students are supposed to learn from physical activities in the classroom needs to be clarified. An increase of the school subject PE and motor skills exercise can be a feasible to improve motor skills and scholastic performance in children and youth, especially when interventions are developed by trained PE teachers. Daily PE in combination with adapted motor skills support can improve not only motor skills but also scholastic performance and proportions of students who reach qualification for higher education. In addition the intervention would produce health-economic gains for society (reduced morbidity costs and productivity gains). Well educated PE teachers are essential for translating research findings into practice since they can properly design motor skill observations, PE programs, and motor skill programs in order to optimize their effect on children´s cognition and scholastic performance. Conclusion: There is limited and inconclusive evidence regarding effects of different PA interventions in school on cognitive functioning and scholastic performance. Moderate levels of PA with cognitive challenges are more effective than aerobic exercise. There is a strong association between motor competence and scholastic performance. PE interventions which include motor skills exercise seem to be more promising than PA in the classroom. Motor skills assessment early in school is associated with later school achievement and can be used as an indicator of children´s future scholastic performance. Daily PE and adapted motor skills training can positively influence motor skills, higher grades and higher proportions of pupils who reach qualification for higher education.
COVID-19, Discipline and Blame: From Italy with a Call for Alternative Futures.

The preventive measures implemented to contain the COVID-19 pandemic in Italy involve the self-isolation of the population. At the same time, I argue, an ethos of self-discipline is promoted, leading to ambiguous results. Although the pandemic may allow some people to imagine a different future, others have perceived it as the beginning of a war. And in this war, the most critical aspect is distributing blame and punishing the agents responsible for the contagion – the undisciplined ones who threaten social collectivity.
(Mis)allocation of Renewable Energy Sources

Policies to incentivize the adoption of renewable energy sources usually offer little flexibility to adapt to heterogeneous benefits across locations. We evaluate the geographical misallocation of solar photovoltaic installations and their relation with the uniform nature of subsidies. We estimate the dispersion of marginal benefits from solar production in Germany and compute the social and private benefits from optimal reallocations of residential solar installations keeping total capacity fixed. Our findings suggest that the value of solar would increase by 5.2% relative to the current allocation using conservative values for the rates of solar installations. Reallocating all solar capacity and taking into account transmission would yield gains that range from about 16% to 30%. A benefit-cost analysis shows that additional transmission can be beneficial if there is sufficient solar capacity reallocated across regions. This puts in perspective the social costs of nationwide policies that do not offer heterogeneous incentives.
Population genomic analyses reveal a highly differentiated and endangered genetic cluster of northern goshawks (Accipiter gentilis laingi) in Haida Gwaii

Accurate knowledge of geographic ranges and genetic relationships among populations is important when managing a species or population of conservation concern. Along the western coast of Canada, a subspecies of the northern goshawk (Accipiter gentilis laingi) is legally designated as Threatened. The range and distinctness of this form, in comparison with the broadly distributed North American subspecies (Accipiter gentilis atricapillus), is unclear. Given this morphological uncertainty, we analyzed genomic relationships in thousands of single nucleotide polymorphisms identified using genotyping‐by‐sequencing of high‐quality genetic samples. Results revealed a genetically distinct population of northern goshawks on the archipelago of Haida Gwaii and subtle structuring among other North American sampling regions. We then developed genotyping assays for ten loci that are highly differentiated between the two main genetic clusters, allowing inclusion of hundreds of low‐quality samples and confirming that the distinct genetic cluster is restricted to Haida Gwaii. As the laingi form was originally described as being based on Haida Gwaii (where the type specimen is from), further morphological analysis may result in this name being restricted to the Haida Gwaii genetic cluster. Regardless of taxonomic treatment, the distinct Haida Gwaii genetic cluster along with the small and declining population size of the Haida Gwaii population suggests a high risk of extinction of an ecologically and genetically distinct form of northern goshawk. Outside of Haida Gwaii, sampling regions along the coast of BC and southeast Alaska (often considered regions inhabited by laingi) show some subtle differentiation from other North American regions. These results will increase the effectiveness of conservation management of northern goshawks in northwestern North America. More broadly, other conservation‐related studies of genetic variation may benefit from the two‐step approach we employed that first surveys genomic variation using high‐quality samples and then genotypes low‐quality samples at particularly informative loci.
Ammonia Exposure Among Citizen Living Surrounding Fertilizer Factory

—Air pollution remains problem around the world. One of dangerous chemical substance is ammonia. Fertilizer factory emission is ammonia that could affect to people health. The purpose of this study was to describe ammonia effect to health among citizen living surrounding fertilizer factory.Methods: This study used cross sectional design. The population in this study was all people living surrounding Fertilizer factory with 300 meters, 800 meters and 2600 meter radius from the factory. The sample in this study was 130 samples. The data analysis was analyzed with univariate. Results: This study found that everyone living them ever had ammonia effect symptom at least two of symptoms, the highest number symptoms was dizzy and cough. The symptoms obtained consist of cough, nasal irritation, hard to breath, throat irritation, sluggish, dizziness, loss of appetite and itchy eyes. Conclusion: supplementation for people living surrounding factory fertilizer should be conducted to prevent more severity of ammonia.
E-WOM as Moderating Effect of Facility and Destination Development to Decision Visiting Perak Island Tourists

Pulau Perak Pulau Seribu Jakarta, has the appeal of soft white sand beaches and turquoise sea water, mangroves and other trees are no less beautiful. From the coast of Perak, the island can see directly to the sea floor, not having to dive, with white sand and coral rocks scattered at the bottom. Based on data from the Central Java Pulau Seribu Statistics Agency 2018, local tourist arrivals to Perak Island are 30 people per month and the number of foreign tourists is 5 people per month, indicating the still low number of tourist visits to Perak Island compared to tourist arrivals in the Pulau Seribu which reached 13,792 people per month. To overcome this problem, it is necessary to increase the attractiveness of tourist destinations and the development of facilities on Perak Island. The purpose of this study is to analyze the Electronic Word of Mouth (E-WoM) as moderating the development of facilities and destinations for tourists visiting the Perak Island Pulau Seribus, Jakarta. The population in this study was Perak Island tourists, with a sample of 100 tourists. The sampling method uses random sampling. Data collection methods using survey methods with research instruments is a questionnaire. The data analysis method uses Structural Equation Model-Partial Least Square 3.0 (SEM-PLS). Based on the results of data analysis it was found that the destination has a positive effect on the decision of visiting tourists, E-WoM has a positive effect on the decision of visiting tourists, E-WoM can increase the Destination of tourist visiting decisions. E-WoM cannot improve the development of facilities on tourist visiting decisions. Researchers suggest increasing the diversity of souvenirs that are typical in tourist areas. Improve the places that tourists must visit and the diversity of recreation that tourists can do. Also increases the availability and accuracy of information clearly. Keywords : visit, destination, E-WOM, facilities, moderation DOI: 10.7176/JTHS/49-06 Publication date: July 31 st 2020