Miracle-dz/UniFAR-FTUs huggingface dataset:
Atezolizumab-induced psoriasis in a patient with metastatic lung cancer—a case report

Immune checkpoint inhibitors, now FDA-approved, are being increasingly used for diverse cancer types. Dermatological complications are most frequent immune-related adverse events during immune checkpoints inhibitors therapies. There is no case reporting psoriasis exacerbation from Asia until now. We present a case of a 53-year-old Chinese man with non-small cell lung cancer (NSCLC) who presented with severe psoriasis at about two weeks after atezolizumab initiation. A skin punch biopsy was performed which revealed these were hyperkeratosis with IL-17A expression positive and confirmed the diagnosis of psoriasis. Atezolizumab was discontinued. Psoriasis was treated with flumethasone ointment every 12 hours and desloratadine 5 mg once daily for 2 weeks instead of phototherapies and improved completely over the next 2 months. He received chemotherapy in 4 cycles and radiotherapy and remained stable disease until December, 2019. Oncologists should pay attention to potential psoriasis exacerbation when patients use anti-programmed death ligand 1 (anti-PD-L1), especially who had a personal psoriasis-related history.
The utility of histological subtype for predicting survival of lung cancer patients with rheumatoid arthritis

Background This study determined whether the survival of lung cancer (LC) patients with rheumatoid arthritis (RA) is differed by histological subtype. Materials This observational, retrospective study compared the LC survival rate of 34 RA patients with that of 132 age- and sex-matched patients without RA who received medical care from 2011 to 2016. Survival curves were generated using the Kaplan-Meier method. Cox proportional hazards regression analyses were used to estimate hazard ratios and determine risk factors predicting mortality according to histological subtype, including small cell lung cancer (SCLC), and non-small cell lung cancer (NSCLC). Results The predominant histological subtype was adenocarcinoma in both groups, however, a larger proportion of SCLC patients was noted in patients with both LC and RA, compared to those with LC but without RA (26.5% vs. 12.9%, respectively; P=0.0317). LC patients with RA had a significantly lower body mass index (P=0.0488), and a higher proportion of interstitial lung disease (P<0.0001), compared to patients without RA. There was no statistical difference in the distribution of smoking status, stage, or comorbidity index between groups. Overall survival did not differ between LC patients with and without RA. Mortality was significantly worse for RA patients with SCLC than those with NSCLC (P=0.0404), and RA was associated with a 3.26-fold increase in mortality for SCLC patients with versus without RA (P=0.0350; 95% confidence interval: 1.05–9.56). However, RA was not a risk factor for mortality in NSCLC and, even in histological subtypes including lung adenocarcinoma and squamous cell carcinoma. Conclusions RA was not associated with a lower overall survival rate for LC patients, irrespective of histological subtype. Because the effects of RA on LC mortality might differ between SCLC and NSCLC patients, future studies should recognize that the histological subtype may affect the outcome.
Phase III non-inferiority study of cabazitaxel (C) 20 mg/m2 (C20) versus 25 mg/m2 (C25) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel (D).

5008Background: The Phase III TROPIC study (NCT00417079) reported a significant improvement in overall survival (OS) for C plus prednisone (P) (25 mg/m2once every 3 weeks plus 10 mg orally once daily) versus mitoxantrone plus P (Hazard Ratio [HR] 0.70; P < 0.0001) in pts with mCRPC previously treated with D. This PROSELICA study (NCT01308580) was designed to determine the relative efficacy and safety profile of C20 plus P compared with C25 plus P. Methods: In this randomized, open-label, multinational phase III study, pts with mCRPC and ECOG performance status 0–2, who progressed after treatment with D, were stratified (ECOG, RECIST, region) and randomized 1:1 to C20 or C25. To show that C20 could preserve ≥ 50% of the efficacy benefit showed by C25 in TROPIC, the HR of C20 vs C25 for the primary endpoint OS could not exceed 1.214 under 1-sided 98.89% confidence level adjusted after interim analyses. Secondary endpoints included progression free survival (PFS), safety, PSA, pain and tumor responses and qu.
Intraobserver and Interobserver Reliability Assessment of the Proximity of Maxillary Molars to the Maxillary Sinus Using Cone-beam CT

Purpose of the study: The aim of the current study was to evaluate the vertical and horizontal relationships between the root apices of maxillary molars and the maxillary sinus floor (MSF). And to examine the Intra- and Interobserver reliability of this assessments.Materials and methods: This retrospective study was conducted at Taibah University Dental College & Hospital. We evaluated the vertical and horizontal relationships between the root apices of maxillary molars and the maxillary sinus floor according to modified classification from Kang et al. 2015 study. Kappa agreement coefficient was calculated to examine the intraobserver and interobserver reliability. Frequency and proportions were tabulated, and Generalized Estimating Equation (GEE) model analysis was performed for the test of significance. Results: The sample contained 216 maxillary molars in total, with 56 missing molars, the analysis was performed on 160 maxillary molars. Kappa agreement coefficient was 0.9857 for intraobserver reliability and were 0.9799 and 0.9803, respectively for interobserver reliability. Concerning vertical measurements, the highest frequency was found in group two (58.8%) where there was close contact between maxillary molar root apices and MSF. For the horizontal relationship, most teeth were in the second group where the MSF is centrally located (37.5%). Conclusion: Our study showed that most of the maxillary molars in our sample had close contact with floor of the maxillary sinus which was centrally located in most of our cases. Also, our study stated that the assessment classification was highly reliable that greatly will assist the clinician to relay on for the assessment and preceding knowledge of relationship between maxillary molars and maxillary sinus floor before any surgical dental procedures which is valuable for preoperative treatment planning and the inhibition of complications.
Surveying Dentists’ Perceptions of Caregiver Refusal of Topical Fluoride

The objective of this study was to assess dentists’ perceptions of caregiver topical fluoride refusal behaviors. We administered an 8-item survey in 2015 and 2016 (N = 582) and asked dentists about the extent to which fluoride refusal is a problem, refusal trends, comfort talking to caregivers who refuse, and perceived reasons why caregivers refuse. To examine geographic variation, we ran χ2 tests between dentists’ location (US West vs. non-West) and the first 3 perception measures (α = 0.05). Nearly 80% of dentists believed fluoride refusal was a problem, and 42.3% believed it was a growing problem. A significantly larger proportion of dentists who saw fluoride refusal as a problem also believed refusal was a growing problem compared to those who thought refusal was not a problem (89.6% and 41.2%, respectively; P < 0.0001). Caregiver characteristics perceived to be associated with fluoride refusal included immunization refusal (41.3%), White race (37.6%), and high income (33.7%). Thirty-seven percent of surveyed dentists were uncomfortable talking to caregivers who refused. There were no geographic differences in perceptions of fluoride refusal as a problem (P = 0.52). A significantly larger proportion of non-West dentists believed fluoride refusal has gotten worse (non-West: 65.5%, West: 41.2%; P < 0.0001), but more dentists from the West were uncomfortable talking to caregivers who refused (West: 86%, non-West: 67.4%; P < 0.0001). Caregiver refusal of topical fluoride may be a growing problem, and many dentists are uncomfortable talking to caregivers who refuse. Additional interdisciplinary research is needed to identify the reasons why caregivers refuse fluoride, which is an important next step in developing chairside interventions that address fluoride refusal behaviors. Knowledge Transfer Statement: The results of this study can be used by researchers to develop chairside strategies to help dentists identify and manage fluoride refusal behaviors in clinical settings. This could help preserve topical fluoride as an evidence-based preventive therapy and address a growing public health problem.
Association of Cost and Medical Service Satisfaction with Korean and Conventional Medicine Use before and after Surgery in Postsurgical Patients: A Questionnaire Survey of Korean Patients with Postsurgical Pain Visiting Korean Medicine Hospitals

This study aimed to assess the costs, health status, and medical service satisfaction with Korean and conventional medicine use before and after surgery of patients visiting Korean medicine hospitals for postsurgical musculoskeletal pain. The study population comprised patients who visited KM hospitals for the first time between June and November 2017 for persistent or recurrent pain and discomfort after low back, neck, shoulder, or knee surgery. Various validated questionnaires were used to collect data. A total of 100 participants were enrolled, and the majority had undergone low back surgery (n = 82). The participants had received 1.3 ± 0.7 magnetic resonance imaging (MRI) examinations and 2.4 ± 2.8 X-rays before surgery. Conventional interventions used before surgery were physical therapy (43%), medications (34%), and injections (28%), in descending order, while 48% of patients reported having received acupuncture 51.3 ± 81.1 times. The mean satisfaction score for surgery was 5.5 ± 2.8 points based on a 9-point Likert scale, while that for KM-based interventions was 6.3 ± 1.7 points. With respect to health-related information, the mean scores were 6.0 ± 2.2 points on the Numeric Rating Scale (NRS), 0.6 ± 0.2 points on the 5-Level EuroQol-5 Dimension (EQ-5D-5L), and 15.3 ± 10.2 on Beck's Depression Index II (BDI-II). The mean score on the Oswestry Disability Index (ODI) in patients with low back pain was 40.1 ± 19.2 points. Work impairment, as measured using the Work Productivity and Activity Impairment Questionnaire: General Health (WPAI-GH), was 62.5 ± 47.8%, while activity impairment was 5.9 ± 2.6%. Participants tended to show low satisfaction regarding surgery and high preference for KM-based interventions. In particular, low back surgery patients reported high ODI scores, indicating high dysfunctional levels and poor prognosis after surgery. It can be inferred that it is therefore important to provide appropriate presurgical and postsurgical care for patients with musculoskeletal pain to improve pain, function, and quality of life.
Comparison of two teat skin sampling methods to quantify teat contamination

The aim of this research was to compare two sampling methods quantifyingmicrobial load on teat ends, especially mastitis pathogens originatingfrom the cows’ surroundings. Methods were compared usinga split udder design, including 132 teat pairs in the study. For the firstmethod, the wet/dry swab technique, a moistened swab was rotated360° around the teat end, followed by a dry swab in the same manner.For the second and new method, the dipping technique, teat endswere immersed in a cup filled with Ringer’s solution and were removedafter five seconds. Microbial load per milliliter as well as per teat endwas calculated by determining the number of total aerobic mesophilicbacteria as well as environmental pathogenic bacteria, including coliformbacteria and esculin-positive streptococci. The concordance correlationcoefficient (CCC) was used to quantify the agreement betweentwo series of measurements and revealed the following coefficients:0.112 for total aerobic mesophilic bacteria; 0.008 for coliform bacteriaand 0.001 for esculin positive streptococci. The results of this studypoint out that under field conditions, the new method does not providesimilar results when compared with the wet/dry swab techniquefor determining teat end microbial load.
Local anaesthetic techniques for the equine head, towards guided techniques and new applications

Summary Perineural nerve blocks are often used in equine practice, especially since the use of diagnostic and surgical procedures in the standing sedated horse have expanded over recent decades. The purpose of this review is to discuss the different perineural nerve blocks for the equine head. The review starts with the currently most used blind approaches as described in textbooks and scientific studies. In human medicine, the role of guided techniques, such as ultrasound guidance, advanced imaging guidance and nerve stimulator guided techniques, is very extensively described. These techniques are promising to use in equine medicine as well. The first studies that describe these techniques in equine cases are also discussed in this review, as well as the possibilities for neuromodulation in equine pain syndromes like equine trigeminus-mediated headshaking and the role of perineural nerve blocks in diagnosing this syndrome.
EXPLORING LANGUAGE AND INTERPERSONAL DYSFUNCTION IN PSYCHOTICISM A Dissertation Submitted to the Graduate School of the University of Notre Dame in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy by

by Xia Allen Much of the research examining interpersonal functioning in individuals with psychoticism traits has focused on the social impact of negative psychotic-spectrum symptoms. Additionally, a significant research literature examines speech features associated with psychoticism traits, but much of this research investigates underlying cognitive mechanisms. Although yet other research indicates that language use is associated with interpersonal functioning and that interpersonal dysfunction is central to the expression of pathological-range traits, there is scarce research dedicated to the questions of whether and how language use affects interpersonal functioning in individuals with psychotic-spectrum traits and symptoms. The current study begins to fill that gap by exploring relations among (1) selfand interviewer-rated psychotic-spectrum traits and symptoms, (2) selfand interviewer-rated interpersonal functioning, and (3) percentage of words in various categories obtained from transcripts of an audio-recorded interview. Preliminary analyses examine the correlations between schizotypy and category percentages in written responses to open-ended prompts. Results of these analyses partially directed the main analyses, which examined the hypothesis that the percentage of words used in several categories, such as verbs, pronouns, and positive and negative emotion words, are correlated with psychotic-spectrum pathology and
MODERATING INFLUENCE OF SELECTED DEMOGRAPHIC VARIABLES ON READING ACHIEVEMENT OF STUDENTS WITH READING DISABILITIES IN IBADAN, OYO STATE

This study investigated the moderating influence of selected demographic variables: gender, age, family type, school type and birth order on reading achievement of students with reading disabilities in Ibadan, Oyo State. The study adopted a descriptive survey, using two hundred and eighty-two (282) students with reading disabilities from seven secondary schools randomly selected from both public and private schools in four (4) local government areas of Oyo State. Participants were selected through random sampling with the use of an adapted version of the Learning Disabilities Screening Inventory by Learning Disabilities Association of Ontario (LDAO, r=0.63). Two other instruments used to collect data for the study were: The Reading Disabilities Screening Test (RDST, r=0.70), and The Students’ Test of Reading (STR, r=0.72). Multiple regression analysis was used to answer two research questions raised. Although the joint contribution of the demographic variables on predicting reading achievement of the study was not significant, the result further showed that two independent variables:gender and family type were independently significant in influencing the reading achievement of students with reading disabilities. Gender had the highest contribution of 29.5% (s=.295, t=4.592, p 0.05), birth order contributed 6.5% (s=.065, t= 1.092,p>0.05), and age had the lowest contribution of 2.0% (s=.020, t=.337, p>0.05). Based on these findings, it was recommended that English Language teachers who teach reading should pay attention to all students in their classrooms, especially those with reading disabilities. This is because when teachers make concerted effort to teach their students, reading achievement of these students improves. This is a trend in a positive direction and should be encouraged at all times.
Study of Bacterial and Fungal Etiology of Lower Respiratory Tract Infections in a Tertiary Care Hospital

Background: Lower respiratory tract infections are most common worldwide both in developed and developing countries. Management of both community & Hospital acquired LRTI’s depends on proper clinical and laboratory diagnosis with current antibiotic sensitivity patterns. The present study was conducted to know the current bacterial & fungal etiology & antibiotic sensitivity patterns in a tertiary care hospital. Materials & Methods: A total of 100 Sputum samples received in the clinical microbiology lab, King George Hospital, Andhra Medical College, were included in the study. Isolation & Identification of the organisms was done as per the standard protocol in the lab. The antibiotic sensitivity test was performed by Kirby Bauer Disc Diffusion method & the zones were measured as per CLSI guidelines. Results: In the present study, out of 100 samples, 54% were culture positive & 46% were culture sterile. Out of 54 culture positives, 29.6% were gram positive cocci, 46.3% were gram negative bacilli & 24% were candida species. Mixed isolates were isolated in 3 samples. Most of the Gram positive bacteria were sensitive to Linezolid 94%, followed by Vancomycin 88%, imipenem 78.6%, Levofloxacin 92%, Ciprofloxacin 60%, Clindamycin 60%, Azithromycin 46% and Amoxyclav 42%. Most of the Gram negative bacteria were sensitive to colistin 94%, followed by imipenem 92%, Piperacillin Tazobactam 80%, Cefoperazone+ sulbactam, Amikacin, Tobramycin 72% each and Cefotaxime 64%. ESBL’s were identified in 29.6% of Gram negative bacteria and Staphylococcus aureus isolated was MRSA. Conclusion: As the drug resistant microbes are increasing, it is imperative to regularly evaluate the etiology & antibiotic profile & formulate regional guidelines for the management of patients suffering from LRTIs.
THE ANALYSIS OF STUDENTS' CRITICAL THINKING IN ONLINE DISCUSSION FORUM BY USING SCHOOLOGY IN SPEAKING

Students have been equipped with technology at their fingertips. They can easily access information anytime and anywhere, as long as the internet connection is available. With the availability of mobile devices in their hands, students can learn better with the aid of Google Classroom. Using Google Classroom can promote their autonomy as this platform helps students to interact, negotiate, and decide the learning process. The study aims to discover students' perspective on the use of Google Classroom in English class among the students of Department of Islamic Economics, Islamic University of Indonesia. The study shows that students enjoy the learning process using this platform. Student-teacher interaction runs pretty well; additionally, feedback on assignments given can also be conducted real time. However, students see that problems, like, unstable internet connection and appropriate instructions on the material’s discussed are points that have to be solved in the
Sexual behavior of adolescents with an emphasis on use of contraceptives / risk of sexually transmitted infections

Aim: The aim of the study was to survey adolescent sexual behavior, use of contraceptives, and sexually transmitted infections, and, in addition, to see how these factors correlated with selected individual characteristics of the respondents (e.g., age, gender). Design: A quantitative cross-sectional study. Methods: An exploratory method, using a specially designed questionnaire, was selected. The research sample consisted of 381 adolescents with an average age of 17.75 years (± 1.28). Data were analyzed using descriptive statistics and the Chi-squared (χ) test (p < 0.05). Results: More than half of adolescents (61.35%; 2.49 ± 1.91) have had sexual intercourse. We found a variety of reasons for differences in the use of contraceptive methods. The most commonly used contraceptive methods during sexual intercourse were male condoms (50.13%), and hormonal pills (16.80%). However, most respondents (86.61%) reported they had not used condoms during their last sexual intercourse. Only 12.86% of respondents considered their sexual behavior safe. Statistically significant differences were found in adolescent sexual behavior relating to contraceptive use in terms of gender and age (p < 0.05). Male adolescents were more likely to use condoms during sexual intercourse, and to use contraceptive methods to prevent sexually transmitted infections. Conclusion: The study revealed that the level of adolescent sexual behavior deserves more attention. Evidence of significant differences should serve as an argument for efforts to increase awareness and education on issues related to sexual health, with an emphasis on the risk of sexually transmitted infections.
Natural Chalcones in Chinese Materia Medica: Licorice

Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely distributed in nature. To date, about 42 chalcones have been isolated and identified from licorice. These chalcones play a pivotal role when licorice exerts its pharmacological effects. According to the research reports, these compounds have a wide range of biological activities, containing anticancer, anti-inflammatory, antimicrobial, antioxidative, antiviral, antidiabetic, antidepressive, hepatoprotective activities, and so on. This review aims to summarize structures and biological activities of chalcones from licorice. We hope that this work can provide a theoretical basis for the further studies of chalcones from licorice.