Miracle-dz/UniFAR-FTUs huggingface dataset:
Could VGF and/or its derived peptide act as biomarkers for the diagnosis of neurodegenerative diseases: A systematic review

Background The increasing ageing population has led to an increase in the prevalence of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). However, as yet, there are no simple biomarkers to predict the onset of such diseases. Recently, VGF and its peptides have been highlighted in neurodegenerative diseases. VGF (non-acronymic) is a polypeptide induced in PC12 cells by neurotrophic factors. Objective This systematic review aimed to determine whether VGF and/or its derived peptides can be used as biomarkers for the diagnosis of ALS, PD, and AD with specific attention to (1) the levels of VGF and/or its derived peptides, (2) amyloid-beta, (3) dopamine, and (4) cognitive score. Methodology A search was undertaken in the Ovid EMBASE, Cochrane Library, PubMed, Scopus, and Web of Science for observational studies. Publications that assessed the level of VGF and/or its derived peptides among people with neurodegenerative diseases and compared them with healthy people were included. The quality of the included studies was assessed using the National Heart, Lung, and Blood Institute Quality Assessment Tool. Result A search of the databases yielded 834 studies, of which, eight observational studies met the inclusion criteria with a total of 673 participants (51.7% males) aged >18 years. Seven studies showed significant decreases in VGF and its derived peptides in adults with AD, PD, and ALS compared to healthy controls (p<0.05). However, one study showed that there was no significant difference in VGF in AD compared to healthy control(p>0.05). Furthermore, only one study reported that VGF levels were positively correlated with those of tissue dopamine but not with Aβ1-42, and low levels of VGF were associated to cognitive deficits. Conclusion The use of VGF and its derivatives for the diagnosis of PD, ALS, AD remains unclear, so further investigation of the role of VGF in neurodegenerative diseases and pathophysiology is needed to provide new insights.
Analyzing the impact of psychological capital and work pressure on employee job engagement and safety behavior

Introduction Buildings and infrastructure are the primary focus of the construction industry, which also includes related activities such as design, planning, demolition, renovation, maintenance, and repair. Safety performance is crucial to the industry's ability to work effectively in spite of hazardous conditions on the job site during any given project. Improving construction workers' safety performance in Malaysia requires an in-depth examination of the interplay between workers' psychological capital, work pressure, employee engagement, and safety participation. Methods Administrative and field workers from different divisions across Malaysia's six regions were randomly sampled to collect data for this study. The workers were given a total of 500 questionnaires, of which 345 were returned to the team of researchers. Based on the data analysis, there is an effective interaction between the factors tested toward safety performance. Results According to findings, psychological capital positively and significantly affected workers' work engagement. Also, work engagement greatly impacted both workers' safety performance outcomes. Also, as expected, worker pressure significantly and negatively affected workers' safety performance. Discussion Insights gained from this research have helped us better organize work and involve employees in safety activities/policies to boost workplace safety performance. The study also suggested that firms should reduce their employees' workloads because doing so would not lower their Psychological Capital but would instead fortify them to better carry out their duties in a risk-free manner.
Early transient dysautonomia predicts the risk of infantile epileptic spasm syndrome onset: A prospective cohort study

Background Infantile epileptic spasm syndrome (IESS) is an age-dependent epileptic encephalopathy with a significant risk of developmental regression. This study investigates the association between heart rate variability (HRV) in infants at risk of IESS and the clinical onset of IESS. Methods Sixty neonates at risk of IESS were prospectively followed from birth to 12 months with simultaneous electroencephalogram (EEG) and electrocardiogram recordings for 60 min at every 2-month interval. HRV metrics were calculated from 5 min time-epoch during sleep including frequency domain measures, Poincare analysis including cardiac vagal index (CVI) and cardiac sympathetic index (CSI), and detrended fluctuation analysis (DFA α1, DFA α2). To assess the effect of each HRV metric at the 2-month baseline on the time until the first occurrence of either hypsarrhythmia on EEG and/or clinical spasm, univariate cox-proportional hazard models were fitted for each HRV metric. Results Infantile epileptic spasm syndrome was diagnosed in 20/60 (33%) of the cohort in a 12-month follow-up and 3 (5%) were lost to follow-up. The median age of developing hypsarrhythmia was 25 (7–53) weeks and clinical spasms at 24 (8–40) weeks. Three (5%) patients had clinical spasms without hypsarrhythmia, and 5 (8%) patients had hypsarrhythmia before clinical spasms at the initial presentation. The infants with high CSI (hazard ratio 2.5, 95% CI 1.2–5.2, P = 0.01) and high DFA α1 (hazard ratio 16, 95% CI 1.1–240, P = 0.04) at 2 months were more likely to develop hypsarrhythmia by the first year of age. There was a trend toward decreasing CSI and DFA α1 and increasing CVI in the first 8 months of age. Conclusion Our data suggest that relative sympathetic predominance at an early age of 2 months may be a potential predictor for developing IESS. Hence, early HRV patterns may provide valuable prognostic information in children at risk of IESS allowing early detection and optimization of cognitive outcomes. Whether early intervention to restore sympathovagal balance per se would provide clinical benefit must be addressed by future studies.
Center of pressure and ground reaction forces in Labrador and Golden Retrievers with and without hip dysplasia at 4, 8, and 12 months of age

Canine hip dysplasia (CHD) is a common orthopedic disease. Owing to the importance of CHD in affected dogs, both clinically and for their use in breeding or work, increasing attention is being given to early diagnosis. Therefore, early clinical and radiological examination of young animals is increasingly in demand, whereas common CHD screening according to the Fédération Cynologique Internationale (FCI) is usually performed at the age of 12 months or even older in Europe. One way to objectively evaluate gait pattern is to measure the ground reaction forces (GRFs) and center of pressure (COP). In this study, we used a pressure plate to evaluate the GRF and COP parameters for 32 Labrador Retrievers and 17 Golden Retrievers at 4, 8, and 12 months of age. The dogs also underwent radiological examination of the hip joints following the FCI rules at the age of at least 12 months, which were grouped as sound (FCI grade A or B) and diseased (FCI grade C or worse). The results revealed significantly higher COP values in both breeds in the diseased limb groups at any measurement point during walking, with the most pronounced results obtained at 8 months of age. Furthermore, COP values during walking were significantly higher at 4 months than at 8 and 12 months in both the sound and diseased limb groups, indicating an increased stability of the gait pattern. Except for COP-Speed, the values of all COP parameters were higher during walking than during trotting at 4 months of age (i.e., COP-Speed was higher when trotting), indicating that the 4-beat gait in walk is more difficult to control for puppies than the 2-beat gait in trot. Overall, our results support the early evaluation of CHD in growing animals using non-invasive methods.
Wnt16 signaling in bone homeostasis and osteoarthristis

Wnts are secreted cysteine-rich glycoproteins involved in joint development and skeletal homeostasis and have been implicated in the occurrence of osteoarthritis. Over the past decade, Wnt16, a member of the Wnt family, has received widespread attention for its strong association with bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. In recent years, further studies have shed light on the role of Wnt16 a positive regulator of bone mass and protective regulator of osteoarthritis progression. Transduction mechanisms and crosstalk involving Wnt16 signaling have also been illustrated. More importantly, local Wnt16 treatment has been shown to ease osteoarthritis, inhibit bone resorption, and promote new bone formation in bone defect models. Thus, Wnt16 is now a potential therapeutic target for skeletal diseases and osteoarthritis. This paper reviews our current understanding of the mechanisms by which Wnt16 signaling regulates bone homeostasis and osteoarthritis.
Factors affecting the adoption of green prevention and control techniques by family farms: Evidence from Henan province of China

Encouraging farmers to adopt green prevention and control techniques (GCTs) is conducive to ensuring the quality and safety of agricultural products, the ecological environment and agricultural production in China. To explore the factors influencing vegetable farmers’ adoption of GCTs, this study utilized the “information-motivation-behavior” intervention (IMB) model and ordered logistic model to empirically study the adoption behavior of 653 vegetable farmers in Henan Province, China. Estimation results indicated that the IMB model significantly predicted farmers’ adoption of GCTs: 1) From the perspective of adoption decisions, 88.82% of the farmers have adopted GCTs, but the degree of adoption is low. 2) the farmers’ adoption of GCTs IMB model specifies that higher levels of GCTs information, motivation, and behavioral skills should result in a greater likelihood of engaging in GCTs adoption behavior. 3) Motivation and behavioral skills are activated through information. 4) Finally, motivation can indirectly affect farmers’ GCTs adoption behavior through behavioral skills. The results of this study support the need for the government to promote the use of GCTs for vegetable pest control, as well as advance integrated prevention and control in the agricultural industry.
Modulation of the symbionts light environment in hospite in scleractinian corals

The upregulation of animal chromoproteins (CPs) during thermal stress produces “colorful” bleached corals that facilitate coral recovery after bleaching. In situ measurements indicate that animal CPs present in coral tissues reduce the elevated internal light environment of the remaining symbionts in bleached or low-pigmented stressed corals. However, there is still a lack of understanding regarding the extent to which animal CPs contribute to modifying the internal light environment of the symbionts in hospite. In this study, we evaluate the effect of three animal CPs on the optical properties of the coral tissue and their internal light environment using a numerical model. The model allows estimations of the absorbance spectra of corals as a function of changes in symbiont and animal pigmentation, as well as descriptions of the light environment in hospite of the symbionts. These descriptions were derived from the quantification of the contribution of each pigment component to light absorption, together with the contribution of the coral skeleton’s reflectance. Simulations indicate that animal CPs upregulation modifies the spectral distribution and the intensity of the internal light field. Animal CPs can reduce up to 11% of the light intensity in hospite when present individually, and up to 24% when present in combination. Such reduction may play a critical role in preventing the full development of the bleached phenotype when irradiance rises to excessive levels at low coral pigmentation, facilitating coral recovery and symbiont tissue re-colonization after bleaching. Accordingly, coral’s CPs components need to also be considered when selecting coral species for future restoration efforts.
Tailoring the clinical management of colorectal cancer by 18F-FDG PET/CT

Colorectal cancer (CRC) is among the most commonly diagnosed gastrointestinal malignancies worldwide. It is inadequate to handle in terms of staging and restaging only based on morphological imaging modalities and serum surrogate markers. And the correct and timely staging of CRC is imperative to prognosis and management. When compared to established sequential, multimodal conventional diagnostic methods, the molecular and functional imaging 18F-FDG PET/CT shows superiorities for tailoring appropriate treatment maneuvers to each patient. This review aims to summarize the utilities of 18F-FDG PET/CT in CRC, focusing on primary staging, follow-up assessment of tumor responses and diagnostic of recurrence. In addition, we also summarize the technical considerations of PET/CT and the conventional imaging modalities in those patients who are either newly diagnosed with CRC or has already been treated from this cancer.
MiRNAs from serum-derived extracellular vesicles as biomarkers for uveal melanoma progression

Uveal melanoma (UM) is a rare type of malignancy that originates from melanocytes in the choroid, iris and the eye’s ciliary body. Biomarkers for early detection and progression of UM, especially the molecular traits governing the development of metastasis, are still not available in clinical practice. One extensively studied components of liquid biopsies are extracellular vesicles. Due to their unique molecular cargo, they can contribute to early cancer development and at the same time carry markers for disease onset and progression. For characterisation of the miRNA profiles present in circulating serum-derived exosomes of patients with diagnosed primary and metastatic UM, we have analyzed the miRNA cargos using next-generation sequencing followed by RT-qPCR validation in a cohort of patients (control n = 20; primary n = 9; metastatic n = 11). Nine miRNAs differentiating these patient groups have been established. We show that hsa-miR-144-5p and hsa-miR-191-5p are the most promising biomarker candidates, allowing the categorization of patients into local and advanced UM. Additionally, the comparison of miRNA expression levels in exosomes derived from UM patients with those derived from healthy donors revealed that hsa-miR-191-5p, -223-3p, -483-5p, -203a has the potential to be used as an early marker for the presence of UM. This pilot study reveals that miRNAs extracted from circulating exosomes could be exploited as potential biomarkers in UM diagnosis and, more importantly, for indicating metastatic spread.
QUANTUM THEORY OF GRAVITY. III. APPLICATIONS OF THE COVARIANT THEORY.

The basic momentum-space propagators and vertices (including those for the fictitious quanta) are given for both the Yang-Mills and gravitational fields. These propagators are used to obtain the cross sections for gravitational scattering of two scalar particles, scattering of gravitons by scalar particles, graviton-graviton scattering, two-graviton annihilation of scalar-particle pairs, and graviton bremsstrahlung. Special features of these cross sections are noted. Problems arising in renormalization theory and the role of the Planck length are discussed. The gravitational Ward identity is derived, and the structure of the radiatively corrected 1-graviton vertex for a scalar particle is displayed. The Ward identity is only one of an infinity of identities relating the many-graviton vertex functions of the theory. The need for such identities may be eliminated in principle by computing radiative corrections directly in coordinate space, using the theory of manifestly covariant Green's functions. As an example of such a calculation, the contribution of conformal metric fluctuations to the vacuum-to-vacuum amplitude is summed to all orders. The physical significance of the renormalization terms is discussed. Finally, Weinberg's treatment of the infrared problem is examined. It is not difficult to show that the fictitious quanta contribute negligibly to infrared amplitudes, and hence that Weinberg's use of the DeDonder gauge is justified. His proof that the infrared problem in gravidynamics can be handled just as in electrodynamics is thereby made rigorous.
GSC-MIM: Global semantic integrated self-distilled complementary masked image model for remote sensing images scene classification

Masked image modeling (MIM) is a learning method in which the unmasked components of the input are utilized to learn and predict the masked signal, enabling learning from large amounts of unannotated data. However, due to the scale diversity and complexity of features in remote sensing images (RSIs), existing MIMs face two challenges in the RSI scene classification task: (1) If the critical local patches of small-scale objects are randomly masked out, the model will be unable to learn its representation. (2) The reconstruction of MIM relies on the visible local contextual information surrounding the masked regions and overemphasizing this local information will potentially lead the model to disregard the global semantic information of the input RSI. Regarding the above considerations, we proposed a global semantic integrated self-distilled complementary masked image model (GSC-MIM) for RSI scene classification. To prevent information loss, we proposed an information-preserved complementary masking strategy (IPC-Masking), which generates two complementary masked views for the same image to resolve the problem of masking critical areas of small-scale objects. To incorporate global information into the MIM pre-training process, we proposed the global semantic distillation strategy (GSD). Specifically, we introduced an auxiliary network pipeline to extract the global semantic information from the full input RSI and transfer the knowledge to the MIM by self-distillation. The proposed GSC-MIM is validated on three publicly available datasets of AID, NWPU-RESISC45, and UC-Merced Land Use, and the results show that the proposed method's Top-1 accuracy surpasses the baseline approaches in three datasets by up to 4.01, 3.87, and 5.26%, respectively.
Cerebral vascular function following the acute consumption of caffeinated artificially- and sugar sweetened soft drinks in healthy adults

Chronic consumption of sugar- and artificially-sweetened beverages (SSB and ASB) are associated with an increased risk of stroke but it is unclear how acute consumption influences cerebral vascular function. Purpose: We hypothesized that: (1) acute consumption of SSB and ASB would augment dynamic cerebral autoregulation (dCA) and attenuate cerebral vascular reactivity to hypercapnia (CVRCO2) compared to water; and (2) dCA and CVRCO2 would be attenuated with SSB compared to ASB and water. Methods: Twelve healthy adults (age: 23 ± 2 years, four females) completed three randomized trials where they drank 500 ml of water, SSB (Mountain Dew®), or ASB (Diet Mountain Dew®). We measured mean arterial pressure (MAP), middle and posterior cerebral artery blood velocities (MCAv and PCAv), and end-tidal CO2 tension (PETCO2). Cerebral vascular conductance was calculated as cerebral artery blood velocity/MAP (MCAc and PCAc). Twenty min after consumption, participants completed a 5 min baseline, and in a counterbalanced order, a CVRCO2 test (3%, 5%, and 7% CO2 in 3 min stages) and a dCA test (squat-stand tests at 0.10 Hz and 0.05 Hz for 5 min each) separated by 10 min. CVRCO2 was calculated as the slope of the linear regression lines of MCAv and PCAv vs. PETCO2. dCA was assessed in the MCA using transfer function analysis. Coherence, gain, and phase were determined in the low frequency (LF; 0.07–0.2 Hz) and very low frequency (VLF; 0.02–0.07 Hz). Results: MCAv and MCAc were lower after SSB (54.11 ± 12.28 cm/s, 0.58 ± 0.15 cm/s/mmHg) and ASB (51.07 ± 9.35 cm/s, 0.52 ± 1.0 cm/s/mmHg) vs. water (62.73 ± 12.96 cm/s, 0.67 ± 0.11 cm/s/mmHg; all P < 0.035), respectively. PCAc was also lower with the ASB compared to water (P = 0.007). MCA CVRCO2 was lower following ASB (1.55 ± 0.38 cm/s/mmHg) vs. water (2.00 ± 0.57 cm/s/mmHg; P = 0.011) but not after SSB (1.90 ± 0.67 cm/s/mmHg; P = 0.593). PCA CVRCO2 did not differ between beverages (P > 0.853). There were no differences between beverages for coherence (P ≥ 0.295), gain (P ≥ 0.058), or phase (P ≥ 0.084) for either frequency. Discussion: Acute consumption of caffeinated SSB and ASB resulted in lower intracranial artery blood velocity and conductance but had a minimal effect on cerebral vascular function as only MCA CVRCO2 was altered with the ASB compared to water.
Vigorous rootstocks improve yields and increase fruit sizes in grafted fresh market tomatoes

Grafting high yielding tomato cultivars (Solanum lycopersicum L.) onto vigorous rootstocks can increase marketable yields, but questions remain regarding optimal cultural and growing conditions such as pinching and plant spacing. This study addressed some of the dynamics between grafted plants and cultural practices. Two scions, ‘Tasti-Lee’ (TL) and ‘Mountain Fresh Plus’ (MFP) were grafted onto each of three rootstocks, ‘Beaufort’, ‘Arnold’, and ‘Shield’. Plants were pinched (removal of main shoot to induce both axillary shoots to grow) or non-pinched, and spaced at 56 or 61 cm. All 32 grafted treatments were compared to the grower standard: non-grafted TL and MFP spaced at 46 cm, which were non-pinched. Fruit quality traits including soluble solids content, pH, lycopene concentration, and titratable acidity were recorded for fruit harvested from tomatoes grafted onto ‘Arnold’, ‘Beaufort’, ‘Shield’ and non-grafted TL. The overall effect of grafting TL and MFP onto vigorous rootstocks ‘Arnold’, ‘Beaufort’, and ‘Fortamino’ increased marketable yields per hectare by 24-35% compared to non-grafted grower standards. The rootstock ‘Shield’ did not significantly increase yields with either scion. TL had a more positive response to grafting than MFP. ‘Arnold’, ‘Beaufort’, and ‘Fortamino’ significantly increased TL fruit size, but the fruit size results were not as significantly impacted by graft treatments for MFP. Plants spaced at 56 compared to 61 cm generated similar yields. Pinched plants significantly increased yields over non-pinched plants by 15% in 2018 but did not impact yield in 2017. No consistent difference was observed between pinched and non-pinched plants with regard to fruit size, only plants grafted with ‘Shield’ benefited significantly from being pinched. Soluble solids content, pH, total lycopene concentration, and titratable acidity differed slightly between grafted and non-grafted plants but was unlikely to positively or negatively affect overall perception of fruit quality in tomatoes. A partial budget analysis revealed that grafting with ‘Arnold’ or ‘Beaufort’ consistently increased profits in this low-disease field.
A review of the circuit-level and cellular mechanisms contributing to locomotor acceleration in the marine mollusk Clione limacina

The pteropod mollusk, Clione limacina, is a useful model system for understanding the neural basis of behavior. Of particular interest are the unique swimming behavior and neural circuitry that underlies this swimming behavior. The swimming system of Clione has been studied by two primary groups—one in Russia and one in the United States of America—for more than four decades. The neural circuitry, the cellular properties, and ion channels that create and change the swimming locomotor rhythm of Clione—particularly mechanisms that contribute to swimming acceleration—are presented in this review.