Miracle-dz/UniFAR-FTUs huggingface dataset:
Autoimmune Pancreatitis Type 1 with Biliary, Nasal, Testicular, and Pulmonary Involvement: A Case Report and a Systematic Review

Introduction: Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition associated with fibroinflammatory lesions that can occur at almost any anatomical site. It often presents as a multiorgan disease that may mimic malignancy, infection, or other immune-mediated conditions. Autoimmune pancreatitis (AIP) type 1 is the most prominent manifestation of IgG4-RD in the digestive tract, with common extra-pancreatic inflammation. We present the first patient with AIP and involvement of the testicles and nasal cavity. Patient and methods: A case of a patient with AIP type 1 and other organ involvement (bile ducts, testicles, nasal polyps, and lungs) is described. Additionally, a systematic review of AIP type 1 with testicular and nasal involvement was conducted. Results: The systematic review found two cases of AIP type 1 with testicular involvement and 143 cases with AIP type 1 with nasal cavity involvement. None of them had both testicular and nasal involvement. Conclusions: This is the first case of AIP type 1 with other organ involvement, including testicular and nasal involvement, to be described. The number of patients with nasal and testicular involvement described in the literature is low. Creating awareness of this rare clinical condition is necessary, especially due to the very effective available treatment with corticosteroids and rituximab.
Visibility Estimated from the Multi-wavelength Sunphotometer during the Winter 2011 Intensive Observation Period at Seoul, Korea

The aerosol extinction vertical profile and surface visibility have been derived from the Microtops-II sunphotometer observation during the winter 2011 intensive observation period (IOP) at Seoul, Korea. Using models of degradation of aerosol optical thickness (AOT) and aerosol scale height, we have performed extinction-visibility modulation to determine the height dependent aerosol extinction and visibility. It is shown that the aerosol loading is relatively low during IOP (mean $AOT_{550}
Information Entropy Theory and Asset Valuation: A Literature Survey

The purpose of this study is to review the empirical work applied to market efficiency, portfolio selection and asset valuation, focusing on the presentation of the comprehensive theoretical framework of Information Entropy Theory (IET). In addition, we examine how entropy addresses the shortcomings of traditional models for valuing financial assets, including the market efficiency hypothesis, the capital asset pricing model (CAPM), and the Black and Scholes option pricing model. We thoroughly reviewed the literature from 1948 to 2022 to achieve our objectives, including well-known asset pricing models and prominent research on information entropy theory. Our results show that portfolio managers are particularly attracted to valuations and strive to achieve maximum returns with minimal risk. The entropy-based portfolio selection model outperforms the standard model when return distributions are non-Gaussian, providing more comprehensive information about asset and distribution probabilities while emphasising the diversification principle. This distribution is then linked to the entropic interpretation of the no-arbitrage principle, especially when extreme fluctuations are considered, making it preferable to the Gaussian distribution for asset valuation. This study draws important conclusions from its extensive analysis. First, entropy better captures diversification effects than variance, as entropy measures diversification effects more generically than variance. Second, mutual information and conditional entropy provide reasonable estimates of systematic and specific risk in the linear equilibrium model. Third, entropy can be used to model non-linear dependencies in stock return time series, outperforming beta in predictability. Finally, information entropy theory is strengthened by empirical validation and alignment with financial views. Our findings enhance the understanding of market efficiency, portfolio selection and asset pricing for investors and decision-makers. Using Information Entropy Theory as a theoretical framework, this study sheds new light on its effectiveness in resolving some of the limitations in traditional asset valuation models, generating valuable insights into the theoretical framework of the theory.
Values of prognostic nutritional index for predicting Kawasaki disease: a systematic review and meta-analysis

Objective This systematic review and meta-analysis aimed to evaluate the relationship between the prognostic nutritional index (PNI) and intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Kawasaki disease (KD). Methods The relevant literature was searched on PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar up to August 5, 2023. A pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under curve (AUC) were calculated to assess the predicted values of PNI in KD patients with IVIG resistance and CAL. Results A total of 8 articles containing 10 studies involving 7,047 participants were included. The pooled results revealed a pooled sensitivity of 0.44 (0.25–0.65), a pooled specificity of 0.87 (0.73–0.94), a pooled PLR of 3.4 (2.0–5.9), a pooled NLR of 0.65 (0.48–0.87), a pooled DOR of 5.26 (2.76–10.02), and a pooled AUC of 0.75 (0.71–0.78) in the diagnosis of KD with CAL. The pooled results suggested that a pooled sensitivity was 0.69 (0.60–0.77), specificity was 0.76 (0.69–0.82), PLR was 2.9 (2.1–4.1), NLR was 0.40 (0.29–0.56), DOR was 7.27 (3.89–13.59), and AUC was 0.79 (0.75–0.82) in the diagnosis of KD with IVIG resistance. The combined results revealed the pooled sensitivity was 0.63 (0.58–0.67), specificity was 0.82 (0.80–0.83), PLR was 3.09 (1.06–8.98), NLR was 0.38 (0.07–2.02), DOR was 8.23 (0.81–83.16) in differentiating KD from febrile patients. These findings demonstrated low sensitivity and relatively high specificity of PNI for KD, KD-CAL, and IVIG-resistant KD. Conclusion In conclusion, this study was the first systematic review and meta-analysis of the diagnostic value of PNI in KD with IVIG resistance and CAL. The results suggested that PNI could be used as biomarkers for distinguish KD, KD with CAL, and KD with IVIG resistance.
An eddy in the subtropical convergence southwest of South Africa

An eddy was observed disrupting the subtropical convergence in the vicinity of the Schmidt-Ott Bank during a cruise of Africana II in March 1964. The subtropical convergence is therefore not necessarily continuous past South Africa, exact conditions probably depending on the seasonal variation in strength of the Agulhas Current. Subantarctic water moved northward both by sinking at the convergence and by mixing along the edge of the eddy. Some effects were observed as deep as the Antarctic Intermediate Water.
High-order oscillatory contributions to shear stress under standing regular wave groups: Theory and experimental evidence

[1] In this paper, the oscillatory contributions to the steady shear stress of regular wave groups propagating over plane beds in the laminar regime are investigated theoretically and experimentally. Assuming weak nonlinearity, it was found that weak-unsteady motions induced by regular wave groups and second-order harmonics induced by nonlinear bottom boundary layer (BBL) dynamics contribute to the same order. Wave reflection was found to be an additional mechanism to generate high-order contributions to the steady shear stress. High-order oscillatory contributions to the steady shear stress generate small-amplitude perturbations to the steady streaming through the BBL. As a result, steady secondary circulation cells can be distinguished in the wave group–induced BBL. The magnitude and length scale of the measured small-amplitude perturbations are consistent with the theoretical predictions. Moreover, it is shown that the oscillatory contributions are selected according to their characteristic timescale with distance to the bed. The results could have important implications for understanding BBL dynamics and transport and the transition to the perturbed laminar regime in multiple-scale oscillatory flows.
A Rare Case of COVID-19 Presenting as Acalculous Cholecystitis

At its onset, coronavirus disease 2019 (COVID-19) commonly presents with generalized myalgia and upper respiratory symptoms. COVID-19 presenting as acalculous cholecystitis has been rarely described in the literature. The following case presents a patient whose first presentation of COVID-19 was acalculous cholecystitis without respiratory symptoms, critical illness, or severe COVID-19 infection.
The influence of season, agricultural management, and soil properties on gross nitrogen transformations and bacterial community structure

The aim of this study was to assess the influence of season, farm management (organic, biodynamic, integrated, and conventional), and soil chemical, physical, and biological properties on gross nitrogen (N) fluxes and bacterial community structure in the semi-arid region of Western Australia. Moisture availability was the dominant factor mediating microbial activity and carbon (C) and N cycling under this climate. In general, microbial biomass N, dissolved organic N, and potentially mineralisable N were greater in organic and biodynamic than integrated and conventional soil. Our results indicate that greater silt and clay content in organic and biodynamic soil may also partly explain these differences in soil N pools, rather than management alone. Although plant-available N (NH4+ + NO3–) was greater in conventional soil, this was largely the result of higher NO3– production. Multiple linear modelling indicated that soil temperature, moisture, soil textural classes, pH, electrical conductivity (EC), and C and N pools were important in predicting gross N fluxes. Redundancy analysis revealed that bacterial community structure, assessed by denaturing gradient gel electrophoresis of 16S rDNA, was correlated with C and N pools and fluxes, confirming links between bacterial structure and function. Bacterial community structure was also correlated with soil textural classes and soil temperature but not soil moisture. These results indicate that across this semi-arid landscape, soil bacterial communities are relatively resistant to water stress.
Acute Kidney Injury in Neonates: A Single-Center Experience

Background: Neonatal intensive care unit infants frequently experience acute kidney damage. Estimates of the prevalence of acute kidney vary depending on the definitions used. In Iraq, studies addressing the prevalence and risk factors of acute kidney injury in this age group are scarce, none of which has implicated the KDIGO diagnostic and staging criteria. Objectives: To describe the prevalence, demographics, risk factors, etiology, and staging of acute kidney injury using KDIGO criteria in the Neonatal intensive care unit and correlate these findings with patient outcomes. Methods: A retrospective study was conducted in the Neonatal Intensive Care Unit/ CWTH/ Medical City Complex/ Baghdad during the period from the 1st of August 2019 to the 15th of January 2020. All neonates diagnosed with acute kidney injury according to KDIGO –classification 2012 and admitted to the neonatal intensive care unit were included in this study. Demographics, clinical staging, and investigations were retrieved from patients' notes. Results: The prevalence of acute kidney damage was 7.2%. The mean gestational age of the patients was 36.8 ± 2.9 weeks, 58% of them were full-term, with a male-to-female ratio of 1.40:1. Stage I patients represented 35.1%, 43.2% were stage 2, and 21.6% had severe stage 3. Acute kidney injury-related mortality was 35.1%. The term female sex, high birth weight, and age younger than seven days at diagnosis predicted a bad prognosis. Vaginally delivered, stage III acute kidney injury-KDIGO, and peritoneal dialysis patients had the worst outcomes. Asphyxia was a major cause of acute kidney injury (P=0.001). High blood urea (P=0.01), low PH (P=0.009), low HCO3 (P=0.001), low WBC count (P=0.001), and low platelet count (0.001) were associated with unfavorable outcomes. Conclusions: The prevalence of acute kidney injury, according to KIDGO diagnostic and staging criteria, is 7.1%. Asphyxia, female gender, and vaginal deliveries are variables associated with poor prognosis in addition to advanced illness stage and laboratory indicators. Received: Dec. 2022 Accepted: Jun 2023 Published: Oct.2023
Type belemnites of Simpson’s Fossils of the Yorkshire Lias

SUMMARY Martin Simpson was curator of the Whitby Museum in the mid-to late-19th century and was influential in systematically collecting and describing the fossils of the North Yorkshire Lower Jurassic (Lias), exposed in mostly excellent coastal sections still accessible today. His species were published in a range of publications between 1843–1884, but, although well described and located, they were not illustrated. The ammonites have subsequently been illustrated, but no comprehensive work illustrating the belemnites has been published. This is a serious omission and the type specimens of 74 of Simpson’s nominal species, from the Lower, Middle and Upper Lias (Sinemurian-Toarcian) are illustrated and discussed here from the originals held in the Whitby Museum.
SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer

Simple Summary In the dynamic realm of cancer research, the Signaling Lymphocyte Activation Molecule (SLAM) family has emerged as a significant factor in modulating immune responses within tumors. This review delves into the roles of specific SLAM members, such as SLAMF8 and SLAMF9, and their impact on tumor progression in cancers like colorectal cancer and melanoma. Recent immunotherapy advances show promise, but challenges like resistance persist. Insights suggest that the SLAM family might be a key to overcoming this resistance. Advances in technology, including single-cell RNA sequencing, help to demystify tumor interactions, and SLAM-focused treatments could potentially revolutionize cancer care. This article underscores the importance of patient safety and calls for thorough research to bring the potential of SLAM in cancer treatment to fruition. Abstract In the field of oncology, the Signaling Lymphocyte Activation Molecule (SLAM) family is emerging as pivotal in modulating immune responses within tumor environments. The SLAM family comprises nine receptors, mainly found on immune cell surfaces. These receptors play complex roles in the interaction between cancer and the host immune system. Research suggests SLAM’s role in both enhancing and dampening tumor-immune responses, influencing the progression and treatment outcomes of various cancers. As immunotherapy advances, resistance remains an issue. The nuanced roles of the SLAM family might provide answers. With the rise in technologies like single-cell RNA sequencing and advanced imaging, there is potential for precise SLAM-targeted treatments. This review stresses patient safety, the importance of thorough clinical trials, and the potential of SLAM-focused therapies to transform cancer care. In summary, SLAM’s role in oncology signals a new direction for more tailored and adaptable cancer treatments.
Continuing currents in cloud‐to‐ground lightning discharges

About 200 excellent photographs of cloud-to-ground discharges, taken with a newly designed rotating-film camera, were obtained from very active thunderstorms in 1959 and 1960. The electric-field changes and luminosity variations of the photographed discharges were recorded simultaneously on two oscilloscopes having different time resolution. Fifty per cent of the multiple-stroke flashes, constituting about 90 per cent of cloud-to-ground flashes, are found to involve at least one stroke which is followed by very long continuing luminosity lasting for 40 to 500 msec. This continuing luminosity contains a number of relatively brighter components essentially the same as the M components which are known to follow some strokes having very short time intervals. The analysis of the electric field associated with the continuing luminosity reveals that, during the luminous period, negative charge from the cloud flows to ground continuously. The surges of current (M components) during the continuing luminosity are associated with the small rapid field changes (K changes), and the time interval between M components is statistically the same as that between the K changes generally observed during the interstroke and final period of cloud-to-ground flashes. During the period of continuing luminosity, the lightning channel maintains a level of conductivity which is high enough to support a momentary current increase without involving the leader process. After the channel loses its luminosity, it maintains a lower level of conductivity for 7 to 100 msec, and a subsequent stroke during this period can also follow the same channel. When a longer time elapses (>100 msec), a subsequent stroke, if any, takes a different channel with a new stepped leader.
Spatial and temporal predictions of soil moisture dynamics, runoff, variable source areas and evapotranspiration for plynlimon, mid-wales.

For many years hydrologists have tried to build physically realistic models which are still simple enough to be fitted to a range of observations made in the field. This is an ongoing process which will become even more difficult as the quality and variety of field and remotely sensed data improves. Hence models must be able to predict soil moisture patterns in time and in space as well as the outflow hydrograph. The model presented here (TOPMODEL) aims to predict the nature of variable source areas in a way that reflects their dynamics over space and time. All component processes are described and shown in operation. As TOPMODEL and similar models have a growing popularity, this paper can be seen as a demonstration of the model's predictive capabilities. The model is applied to the catchments of Plynlimon, mid-Wales for 1984, 1985 and 1986 data sets. The model has been thoroughly tested and cross-validated against independent data sets for different time periods, for a separate catchment, for internal gauges and for wet and dry periods. The resulting predicted soil moisture patterns show a small, semi-permanent variable source area that has the ability during large storms to expand dynamically over short time periods. Spatial predictions of evapotranspiration are also shown which reflect the influence of soil moisture patterns on this process. The weakest component of the model is the representation of root zone evaporation and how this pre-sets the antecedent condition of the catchment during long dry periods.
Treatment of Soft Tissue Defects after Minimally Invasive Plate Osteosynthesis in Fractures of the Distal Tibia: Clinical Results after Reverse Sural Artery Flap

Introduction: Distal tibial fractures make up approximately 3% to 10% of all tibial fractures or about 1% of lower extremity fractures. MIPO is an appropriate procedure and method to achieve stable metal plate fixation and osseointegration by minimizing soft tissue damage and vascular integrity at the fracture site. MIPO to the medial tibia during distal tibial fractures induces skin irritation due to the thickness of the metal plate, which causes discomfort and pain on the medial side of the distal leg, and if severe, complications such as infection and skin defect may occur. The reverse sural flap is a well-researched approach for covering defects in the lower third of the leg, ankle, and foot. Materials and Methods: Among 151 patients with distal tibia fractures who underwent minimally invasive metal plate fixation, soft tissue was injured due to postoperative complications. We treated 13 cases with necrosis and exposed metal plates by retrograde nasogastric artery flap surgery. For these patients, we collected obligatory patient records, radiological data, and wound photographs of the treatment results and complications of reconstructive surgery. Results: In all the cases, flap survival was confirmed at the final outpatient follow-up. The exposed area of the metal plate was well coated, and there was no plate failure due to complete necrosis. Three out of four women complained of aesthetic dissatisfaction because the volume of the tunnel through which the skin mirror passed and the skin plate itself were thick. In two cases, defatting was performed to reduce the thickness of the plate while removing the metal plate. Conclusions: Metal plate exposure after distal tibial fractures have been treated with minimally invasive metal plate fusion and can be successfully treated with retrograde nasogastric artery flaps, and several surgical techniques are used during flap surgery.
Climatology of Large Peak Current Cloud‐to‐Ground Lightning Flashes in China’s Most Populous Areas

Using a 10‐year data set of cloud‐to‐ground lightning (CG) flashes, the climatological characteristics of ±CG flashes with a large peak current (>75 kA or <−75 kA) (±LPCCGs) are for the first time obtained in China’s most populous areas in terms of density distribution, seasonal variation, and monthly and diurnal evolution. The results show that the distribution of +LPCCG flashes has evident seasonal variations, while the activity center of −LPCCG flashes always remains in Southwest China. The diurnal evolution of +LPCCG flash percentages in southern China’s Mainland shows an opposite trend to that in the north. Furthermore, the peak current distributions of +LPCCG flashes in most of China’s mainland are found to be distinct from those shown in other regions of the world. Additionally, Southwest China is found to be an important and special area for LPCCG flash activity in China. Not only is it the density center of ±LPCCG flashes, but the peak current distribution of −LPCCG flashes in this region also shows an evidently different pattern from those in other regions. The diurnal evolution of the ‐LPCCG/+LPCCG flash frequencies in Southwest China also shows a different pattern from that in other regions.
South American reference pole for the mid-Cretaceous: Further constraints in the interpretation of Andean paleomagnetic data

A paleomagnetic study of the Aptian Cerro Barcino Formation in central Patagonia showed the presence of a stable magnetization with a positive tilt test. The obtained pole position (lat 85°S, long 181°E, α 95 = 5.6°, N = 11) differs from reliable Early and Late Cretaceous South American cratonic poles. The Cerro Barcino pole overlaps coeval poles from the Chilean Andean fore arc previously interpreted to record crustal block rotations. This new result indicates that previously published Andean tectonic models must be reviewed.