Miracle-dz/UniFAR-FTUs huggingface dataset:
Competing Health Risks Associated with the COVID-19 Pandemic and Response: A Scoping Review

modeling. AEK, DD, RPM, and JM drafted other sections of the manuscript. All authors reviewed and agreed upon the final version of the manuscript. This assessment represents the views of the authors and not official positions of their employers. Abstract Background COVID-19 has rapidly emerged as a global public health threat with infections recorded in nearly every country. Responses to COVID-19 have varied in intensity and breadth, but generally have included domestic and international travel limitations, closure of non-essential businesses, and repurposing of health services. While these interventions have focused on testing, treatment, and mitigation of COVID-19, there have been reports of interruptions to diagnostic, prevention, and treatment services for other public health threats. We conducted a scoping review to characterize the impact of COVID-19 on HIV, tuberculosis, malaria, sexual and reproductive health, and malnutrition. Methods A scoping literature review was completed using searches of PubMed and preprint servers (medRxiv/bioRxiv) from January 1 st to October 31 st , 2020, using Medical Subject Headings (MeSH) terms related to SARS-CoV-2 or COVID-19 and HIV, tuberculosis, malaria, sexual and reproductive health, and malnutrition. Empiric studies reporting original data collection and mathematical models were included, and available data synthesized by region. Studies were excluded if they were not written in English.
Real-World Adherence to Toxicity Management Guidelines for Immune-Related Adverse Events

Immune checkpoint inhibitors (ICIs) affect immunologic homeostasis, leading to immune-related adverse events (irAEs). Early irAE detection and management can prevent significant morbidity and mortality. A retrospective chart review was performed to characterize irAEs associated with nivolumab, ipilimumab, and nivolumab plus ipilimumab in adult medical oncology patients in Nova Scotia Health-Central Zone from 2013–2020, and to describe adherence to toxicity management guidelines. Diarrhea/colitis, hepatitis, pneumonitis, nephrotoxicity, and cardiotoxicity were studied. Of 129 charts reviewed, 67 patients (51.9%) experienced at least one irAE for a total of 98 irAEs and a 1.5% fatality rate. Of these irAEs, 33.7% led to an emergency room visit. Patients were admitted to hospital and steroids were used in 24.5% and 35.7% of cases, respectively. In 17.3% of irAEs, ICIs were permanently discontinued. In 20.4% of irAEs, ICIs were held, and patients were monitored; while in 18.4%, ICIs were held until the irAE was Grade 0–1 (and until steroids were tapered). Almost 47% of irAEs were managed according to guidelines (14.3% were not), and 38.8% had no documented management. Patients receiving immunotherapy frequently experience irAEs with half of irAEs having documented management adhering to guidelines. As immunotherapy indications expand, it is important to ensure irAEs are documented and managed appropriately.
Cardiovascular risk factors in employees of a Alagoas industry

Introduction: Cardiovascular diseases are a serious public health problem in Brazil and comprise one of the causes of absence from work. However, its occurrence can be avoided if there is an early identification of cardiovascular risk factors. Objective: To investigate the frequency of cardiovascular risk factors in employees of an industry in Alagoas and to investigate differences in their occurrence between the sectors of work. Methods: This is an analytical cross-sectional, carried out in February 2019, with employees from the administrative sector and the operational sector of an industry in Alagoas. Sociodemographic, anthropometric, clinical and lifestyle data were collected. Altered blood pressure, anthropometric indicators of cardiovascular risk, smoking, alcohol consumption, physical inactivity and personal or family history of chronic diseases were considered as cardiovascular risk factors. The statistical analysis was performed with the statistical package R, using the package Rcmdr. In order to ascertain possible differences between risk factors in employees of the administrative sector and the operational sector, the t test for independent samples was performed, when continuous variables, and the Pearson chi-square test was performed, when categorical variables, adopting a level significance of 5%. Results: 56 employees were evaluated, with a mean age of 33 ± 8.5 years. Of these, 80.4% were male, 62.5% were overweight, 58.9% consumed alcohol, 53.6% performed some physical activity and 51.8% had a cardiovascular family history. There was no difference in the occurrence of these factors between the sectors of work. Conclusion: The most frequent cardiovascular risk factors were overweight, alcohol consumption and presence of family history, with no difference being identified between workers in the operational sector and the administrative sector. However, the presence of these factors is worrying, mainly because it is a relatively young sample. ABSTRACT
Utilizing Distributed Vibration Absorbers to Reduce Noise Transmission Through the Windshield of a Cessna 150

High levels of noise have historically been present in the interior of aircrafts. This causes passenger, pilot, and other aircraft employee fatigue as well as speech interference and discomfort issues. In general aviation aircraft, little has been done to reduce the noise in the interior of fuselages. Noise transmitting into the cabin of a single engine aircraft is complex. Researchers have identified areas of noise transmission in general aviation aircraft to include the windshield, exhaust, side windows, and little through the engine firewall. Sources originally noted that structure-borne and airborne noise transmission paths were equal contributors to interior energy penetration of single-engine aircraft. However, additional studies found that airborne noise transmission paths dominate interior energy transmission for single-engine aircraft. Energy transmits mostly through the front of the aircraft via the windshield. Reducing interior aircraft noise levels is a complicated joint effort, combining propeller radiation control; fuselage wall reduction methods; exhaust emission regulation, management of air turbulence; some propeller, wake-induced vibration control; and a little engine vibration restraint. For minimum propeller acoustic propagation, it is important to control propeller radiation by using techniques such as increasing the number of blades, altering blade airfoil (especially using a felix or grooved design); applying small angle of attack; utilizing swept blades; decreasing blade diameter; lowering tip speed; and reducing the load on a propeller (i.e. by controlling the blade thickness, tip volume, and blade shape). Controlling the vibration in the fuselage skin can also help to reduce interior noise. Some early attempts were made using ribs/stiffeners, tuned dampers, and a limp mass double wall. More recently, dynamic vibration absorbers have been utilized, quite successfully, to reduce fuselage skin vibration and thus, interior noise levels. Attempting to control the exhaust emission and induced vibration from air turbulence has contributed to lower airplane cabin noise levels as well. For large aircrafts, the
Interest and Enthusiasm in Learning English as Foreign Language in Senior High School and How Both Relate to English Achievement

Interest and enthusiasm are internal factors known to an extent to have an influence toward learning in general. This study aims at checking these three variables relationship: interest, enthusiasm, and English achievement. It was conducted in Sungai Liat Regency, Bangka Belitung Islands, Indonesia, in a state senior high school which provided 70 students to be the sample of this study from the population of 183 students in the school. The instruments used were: Interest and Enthusiasm Questionnaire and Students’ English score documentation. The data collected using the questionnaire were divided into two parts: interest and enthusiasm. Both data were analyzed using Pearson Product Moment Correlation Coefficient to see the association of interest toward enthusiasm. Furthermore, data from each one of the two variables and combined data from both variables were also analyzed using Pearson Product Moment Correlation Coefficient to find out how both variables as relate toward English achievement. The results show that interest in learning English had a strong significant association toward enthusiasm ( r (70)=. 77, p =0.00). Furthermore, both interest and enthusiasm had a significant association toward English achievement (respectively: r (70)=. 40, p =0.001; r (70)=. 24, p =0.046). Moreover, the combination of both interest and enthusiasm also showed a strong association toward English achievement ( r (70)=. 343, p =0.004). This study also provided some implications and recommendations for further research.
Network Flexibility for Recourse Considerations in Bi-Criteria Facility Location

What is the best set of facility location decisions for the establishment of a logistics network when it is uncertain how a company’s distribution strategy will evolve? What is the best configuration of a distribution network that will most likely have to be altered in the future? Today’s business environment is turbulent, and operating conditions for firms can take a turn for the worse at any moment. This fact can and often does influence companies to occasionally expand or contract their distribution networks. For most companies operating in this chaotic business environment, there is a continuous struggle between staying cost efficient and supplying adequate service. Establishing a distribution network which is flexible or easily adaptable is the key to survival under these conditions. This research begins to address the problem of locating facilities in a logistics network in the face of an evolving strategic focus through the implicit consideration of the uncertainty of parameters. The trade-off of cost and customer service is thoroughly examined in a series of multi-criteria location problems. Modeling techniques for incorporating service restrictions for facility location in strategic network design are investigated. A flexibility metric is derived for the purposes of quantifying the similarity of a set of non-dominated solutions in strategic network design. Finally, a multi-objective greedy random adaptive search (MOG) metaheuristic is applied to solve a series of bicriteria, multi-level facility location problems.
Event-Triggered Zero-Gradient-Sum Distributed Algorithm for Convex Optimization with Time-Varying Communication Delays and Switching Directed Topologies

Nowadays, distributed optimization algorithms are widely used in various complex networks. In order to expand the theory of distributed optimization algorithms in the direction of directed graph, the distributed convex optimization problem with time-varying delays and switching topologies in the case of directed graph topology is studied. The event-triggered communication mechanism is adopted, that is, the communication between agents is determined by the trigger conditions, and the information exchange is carried out only when the conditions are met. Compared with continuous communication, this greatly saves network resources and reduces communication cost. Using Lyapunov-Krasovskii function method and inequality analysis, a new sufficient condition is proposed to ensure that the agent state finally reaches the optimal state. The upper bound of the maximum allowable delay is given. In addition, Zeno behavior will be proved not to exist during the operation of the algorithm. Finally, a simulation example is given to illustrate the correctness of the results in this paper.
MOLECULAR BASIS FOR ENZYMATIC SULFITE OXIDATION – HOW THREE CONSERVED ACTIVE SITE RESIDUES SHAPE ENZYME ACTIVITY

: Sulfite dehydrogenases (SDHs) catalyze the oxidation and detoxification of sulfite to sulfate, a reaction critical to all forms of life. Sulfite-oxidizing enzymes contain three conserved active site amino acids (Arg-55, His-57, and Tyr-236) that are crucial for catalytic competency. Here we have studied the kinetic and structural effects of two novel and one previously reported substitution (R55M, H57A, Y236F) in these residues on SDH catalysis. Both Arg-55 and His-57 were found to have key roles in substrate binding. An R55M substitution increased Km(sulfite)(app) by 2-3 orders of magnitude, whereas His-57 was required for maintaining a high substrate affinity at low pH when the imidazole ring is fully protonated. This effect may be mediated by interactions of His-57 with Arg-55 that stabilize the position of the Arg-55 side chain or, alternatively, may reflect changes in the protonation state of sulfite. Unlike what is seen for SDHWT and SDHY236F, the catalytic turnover rates of SDHR55M and SDHH57A are relatively insensitive to pH (~;;60 and 200 s-1, respectively). On the structural level, striking kinetic effects appeared to correlate with disorder (in SDHH57A and SDHY236F) or absence of Arg-55 (SDHR55M), suggesting that Arg-55
NDT_A_259499 971..990

1Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; 2Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; 3Department of Neuroscience, University of Florida, Gainesville, FL, USA Background: Transcranial direct current stimulation (tDCS) has been proposed as a possible method for remediating age-associated cognitive decline in the older adult population. While tDCS has shown potential for improving cognitive functions in healthy older adults, stimulation outcomes on various cognitive domains have been mixed. Methods: A systematic search was performed in four databases: PubMed, EMBASE, Web of Science, and PsychInfo. Search results were then screened for eligibility based on inclusion/exclusion criteria to only include studies where tDCS was applied to improve cognition in healthy older adults 65 years and above. Eligible studies were reviewed and demographic characteristics, tDCS dose parameters, study procedures, and cognitive outcomes were extracted. Reported effect sizes for active compared to sham group in representative cognitive domain were converted to Hedges’ g. Main Results: A total of thirteen studies involving healthy older adults (n=532, mean age=71.2+5.3 years) were included in the meta-analysis. The majority of included studies (94%) targeted the prefrontal cortex with stimulation intensity 1–2 mA using various electrode placements with anodes near the frontal region. Across all studies, we found Hedges’ g values ranged from −0.31 to 1.85 as reported group effect sizes of active stimulation compared to sham. Conclusion: While observed outcomes varied, overall findings indicated promising effects of tDCS to remediate cognitive aging and thus deserves further exploration. Future characterization of inter-individual variability in tDCS dose response and applications in larger cohorts are warranted to further validate benefits of tDCS for cognition in healthy older adults.
A Brief Overview of Ammonia and Urea Production and Their Simulations Strategies

To engender a simulation of the integrated Ammonia - Urea process, a literature review was carried out about these industrial processes, focusing on extracting information from the literature, such as the types of processes and their description, thermo-physical-chemical properties, and thermodynamic and kinetic models related to the process. Furthermore, research was carried out on thermodynamic models for NH3 -CO 2 -H 2O systems, capable of describing an integrated Ammonia-Urea plant.
Feminist Peace Research in Europe: A Snapshot

This chapter explores the long trajectory of European feminists’ contributions to peace research. Speciﬁcally, the coalescing of knowledge via speciﬁc Centers of Excellence has supported the recent development of feminist peace research (FPR) in Europe. FPR has also been inﬂu-enced by the global normative framework of the Women, Peace and Security agenda (WPS), which relies on research conducted outside of Europe. While the diversity of WPS informed research evidences a thriving FPR ﬁeld in Europe, it also reveals the limitations of what constitutes ‘Europe. ’ Ultimately, the chapter shows how FPR remains exclusionary, with implications for knowledge production hierarchies.
FailureMarrow Transplantation after Engraftment Promotes Engraftment for Secondary Bone Primary Bone Marrow Transplantation CD154:CD40 Costimulatory Blockade at Strategic Nonmyeloablative Conditioning:

There is an increased risk of failure of engraftment following nonmyeloablative conditioning. Sensitization resulting from failed bone marrow transplantation (BMT) remains a major challenge for secondary BMT. Approaches to allow successful retransplantation would have signiﬁcant beneﬁts for BMT candidates living with chronic diseases. We used a mouse model to investigate the effect of preparative regimens at primary BMT on outcome for secondary BMT. We found that conditioning with TBI or recipient T cell lymphodepletion at primary BMT did not promote successful secondary BMT. In striking contrast, successful secondary BMT could be achieved in mice conditioned with anti-CD154 costimulatory molecule blockade at ﬁrst BMT. Blockade of CD154 alone or combined with T cell depletion inhibits generation of the humoral immune response after primary BMT, as evidenced by abrogation of production of anti-donor Abs. The humoral barrier is dominant in sensitization resulting from failed BMT, because almost all CFSE-labeled donor cells were killed at 0.5 and 3 h insensitized recipients in in vivo cytotoxicity assay, reﬂecting Ab-mediated cytotoxicity. CD154:CD40 costimulatory blockade used at primary BMT promotes allogeneic engraftment in secondary BMT after engraftment failure at ﬁrst BMT. The prevention of generation of anti-donor Abs at primary BMT is critical for successful secondary BMT. The Journal of Immunology, 2008, 181: 6616–6624.
Myeloid NADPH Oxidase Reduces Tumor Growth by Targeting the Monocyte-Derived Dendritic Cells and Histamine Promotes the Development of

The efﬁciency of immune-mediated clearance of cancer cells is hampered by immunosuppressive mediators in the malignant mi-croenvironment, including NADPH oxidase–derived reactive oxygen species. We aimed at deﬁning the effects of histamine, an inhibitor of the myeloid NADPH oxidase/NOX2, on the development of Ag-presenting dendritic cells (DCs) from myeloid precursors and the impact of these mechanisms for tumor growth. Histamine was found to promote the maturation of human DCs from monocytes by increasing the expression of HLA-DR and costimulatory molecules, which resulted in improved induction of Th cells with Th0 polarity. Experiments using wild-type and NOX2 -deﬁcient myelomonoblastic cells showed that histamine facilitated myeloid cell maturation only in cells capable of generating reactive oxygen species. Treatment of mice with histamine reduced the growth of murine EL-4 lymphomas in parallel with an increment of tumor-inﬁltrating DCs in NOX2 -sufﬁcient mice but not in NOX2 -deﬁcient ( gp91 phox 2 / 2 ) mice. We propose that strategies to target the myeloid NADPH oxidase may facilitate the development of endogenous DCs in cancer. The Journal of Immunology , 2015, 194: 000–000. stress (9, 10). These results formed the basis for the inclusion of histamine in cancer immunotherapy protocols (13). A histamine salt (histamine dihydrochloride) was recently approved for therapeutic use in acute myeloid leukemia within the European Union and in Israel (14, 15). High levels of NADPH oxidase/NOX2-derived ROS were suggested to impede the maturation of immature myeloid cells into macrophages and DCs (16). For the current study, we sought to deﬁne whether the ROS-inhibitory properties of histamine trans-late into facilitated differentiation of myeloid cells, including the development of DCs. Our results imply that histamine promotes myeloid cell differentiation, including the development of monocyte-derived DCs, by targeting the NADPH oxidase/NOX2 and that these properties have implications for tumor growth.
Research into milk homogenization in the pulsation machine with a vibrating rotor

In the modern dairy production schemes one of the main problems is high energy consumption in the process of homogenization. One of the perspective ways to solve this problem is to research and develop the variety of rotor-pulsation machine – pulsation machine with a vibrating rotor. Homogenization in such machine allows getting high values of emulsion flow acceleration and using the resonance phenomenon that has a positive impact on quality and energy consumption of the machine. As a result of analytical researches, the hypothesis is suggested about the key role of emulsion acceleration in the process of milk emulsion fat phase dispersing in the pulsation machine with a vibrating rotor. We received dependences that associate instantaneous and average acceleration of the emulsion with the frequencies of rotation and vibration of the rotor, its diameter and amount of openings. These dependences allow determining conditions for increasing degree of emulsion dispersing. The experimental researches resulted in defining interconnection between acceleration of emulsion and dispersion of fat phase of milk, which confirms the hypothesis about the mechanism of homogenization in the pulsation machine with a vibrating rotor. The middle sizes of fat globules of milk are found to be dependent on the frequency of rotation and amplitude of rotor vibration. With the frequencies of rotation of the crank shaft up to 2880 rpm and amplitude of rotor oscillation 1 mm it is possible to get milk emulsion with the average size of around 0.8 μm. The results of the research prove the use of such machines in the technological processing lines of milk to be promising. The investigated machine allows receiving highly dispersed emulsion that is on the same level as processed in valve homogenizers with considerable decrease in energy consumption.
Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma

Simple Summary Membrane-associated PCNA is expressed on the surface of human MM cell lines and primary MM cells. Mab 14-25-9 interacts with membrane-associated PCNA and blocks its binding to NK-expressed NKp44, thus activating NK function. We showed that mAb 14-25-9 can serve as an immune checkpoint blocker, enhancing the function of NK cells on target human MM cell lines and primary cells. Abstract Multiple Myeloma (MM) is a devastating malignancy that evades immune destruction using multiple mechanisms. The NKp44 receptor interacts with PCNA (Proliferating Cell Nuclear Antigen) and may inhibit NK cells’ functions. Here we studied in vitro the expression and function of PCNA on MM cells. First, we show that PCNA is present on the cell membrane of five out of six MM cell lines, using novel anti-PCNA mAb developed to recognize membrane-associated PCNA. Next, we stained primary bone marrow (BM) mononuclear cells from MM patients and showed significant staining of membrane-associated PCNA in the fraction of CD38+CD138+ BM cells that contain the MM cells. Importantly, blocking of the membrane PCNA on MM cells enhanced the activity of NK cells, including IFN-γ-secretion and degranulation. Our results highlight the possible blocking of the NKp44-PCNA immune checkpoint by the mAb 14-25-9 antibody to enhance NK cell responses against MM, providing a novel treatment option.