Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk of exposure to prescription opioids in children and adolescents with autism spectrum disorder: A nationwide longitudinal study

Whether children and adolescents with autism spectrum disorder (ASD) are more likely to be exposed to prescription opioids than others remains unknown. The Taiwan National Health Insurance Research Database was employed, and 14,849 children and adolescents with ASD and 148,490 age‐ and sex‐matched non‐ASD controls were enrolled between 2001 and 2009 and followed up till the end of 2011. Those exposed to prescription opioids during the follow‐up period were identified. Patients with ASD were more likely to be exposed to prescription opioids (hazard ratio [HR]: 4.95, 95% confidence interval [CI]: 4.50–5.45), including intravenous or intramuscular opioids (HR: 5.80, 95% CI: 5.23–6.43) and oral or transcutaneous opioids (HR: 2.32, 95% CI: 1.87–2.89), than were non‐ASD controls. Furthermore, the ASD cohort had the increased likelihood of cumulative exposure of >14 days (HR: 6.19, 95% CI: 4.91–7.79) and >30 days (HR: 7.17, 95% CI: 5.19–9.90) to prescription opioids compared with the control cohort. ASD was a risk factor for exposure to prescription opioids. Close monitoring of prescription opioid use is necessary for at‐risk children and adolescents with ASD, such as those having with or chronic pain. We found that patients with ASD were more likely to be exposed to prescription opioids, including intravenous or intramuscular opioids and oral or transcutaneous opioids, than were non‐ASD controls. We suggest that close monitoring of prescription opioid use is necessary for at‐risk children and adolescents with ASD, such as those having with or chronic pain.
Exosome‐shuttled mitochondrial transcription factor A mRNA promotes the osteogenesis of dental pulp stem cells through mitochondrial oxidative phosphorylation activation

The treatment of bone defects by stem cells (MSCs) has achieved limited success over the recent few decades. The emergence of exosomes provides a new strategy for bone regeneration. Here, we aimed to investigate the effect and mechanisms of exosomes combined with dental pulp stem cells (DPSCs) on bone regeneration.
Quantitative proteomics identifies TUBB6 as a biomarker of muscle‐invasion and poor prognosis in bladder cancer

Muscle‐invasive urothelial carcinoma (MIUC) of the bladder shows highly aggressive tumor behavior, which has prompted the quest for robust biomarkers predicting invasion. To discover such biomarkers, we first employed high‐throughput proteomic method and analyzed tissue biopsy cohorts from patients with bladder urothelial carcinoma (BUC), stratifying them according to their pT stage. Candidate biomarkers were selected through bioinformatic analysis, followed by validation. The latter comprised 2D and 3D invasion and migration assays, also a selection of external public datasets to evaluate mRNA expression and an in‐house patient‐derived tissue microarray (TMA) cohort to evaluate protein expression with immunohistochemistry (IHC). Our multilayered platform‐based analysis identified tubulin beta 6 class V (TUBB6) as a promising prognostic biomarker predicting MIUC of the bladder. The in vitro 2D and 3D migration and invasion assays consistently showed that inhibition of TUBB6 mRNA significantly reduced cell migration and invasion ability in two BUC cell lines with aggressive phenotype (TUBB6 migration, P = .0509 and P < .0001; invasion, P = .0002 and P = .0044; TGFBI migration, P = .0214 and P = .0026; invasion, P < .0001 and P = .0001; T24 and J82, respectively). Validation through multiple public datasets, including The Cancer Genome Atlas (TCGA) and selected GSE (Genomic Spatial Event) databases, confirmed TUBB6 as a potential biomarker predicting MIUC. Further protein‐based validation with our TMA cohort revealed concordant results, highlighting the clinical implication of TUBB6 expression in BUC patients (overall survival: P < .001). We propose TUBB6 as a novel IHC biomarker to predict invasion and poor prognosis, also select the optimal treatment in BUC patients.
Eye Health-seeking Behaviour of Traders in Rural Nigeria

Aim: The aim of this article was to determine the healthcare provider first sought, reasons for the choice, and symptom duration before hospital presentation among traders in rural Nigeria. Materials and Methods: This was a cross-sectional study of traders at a rural Nigerian market, selected by systematic random sampling. A structured questionnaire was used to obtain information on sociodemographics, eye disease symptoms, eye care provider first sought, and reasons for choice. The analysis was carried out with Statistical Package for Social Sciences using descriptive and inferential statistics with an alpha level at 0.05. Results: Of the 177 traders, 88 (49.7%) were males and 89 (50.3%) were females. The mean age was 46.5 ± 13.75 years (range 19–72). Of the 83 traders who had ocular symptoms 23 (27.7%) never sought any care. The eye care providers first sought were patent medicine vendors 22 (26.5%), orthodox hospital 17 (20.5%), eye glass vendors 3 (3.6%), and traditional healers 3 (3.6%). The median symptom duration before presentation to an eye health facility was 83 days. Reasons for not seeking orthodox eye care first included cost 33 (39.8%), ‘ailment not serious’ 22 (26.5%), and advice from friends 7 (8.4%). Females were more likely to seek orthodox care (χ2=4.22, P=0.04), whereas males were more likely to feel that their ailment was not serious. Traders aged >50 years were less likely to seek any care for eye ailment (χ2 =8.41, P=0.04). Conclusion: Traders with eye disorders seek care late and most first seek care outside the orthodox hospital. Cost and feeling that ailment was not serious are barriers to seeking orthodox eye care. Eye health education and cost reduction would improve uptake of orthodox eye care services.
Inﬂuence of chlorine substitution on adsorption of gaseous chlorinated phenolics on multi-walled carbon nanotubes embedded in SiO 2

Multi-walled carbon nanotubes (MWCNTs) embedded in SiO 2 particles were prepared through the ﬂoating-catalyst chemical vapor deposition method. The parameters reaction time and ﬂow rate of the carbon source (CH 4 ) were studied to obtain optimum conditions for MWCNT synthesis. The obtained MWCNTs were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, and Fourier transform infrared spectroscopy to conﬁrm their morphology and crystallinity. The optimum conditions were a CH 4 ﬂow rate of 100 ml/min in a H 2 –Ar mixture at a ﬂow rate of 500 ml/min and a reaction time of 20 min. Under these conditions, MWCNTs with average outer and inner diameters of around 50 and 10 nm, respectively, were obtained. SiO 2 particles with embedded MWCNTs were studied for their adsorption of gaseous chlorinated phenolic compounds (CPCs), with emphasis on the effect of number of chlorine substituents. The CPC compounds of 2-chlorophenol (CP) and 2,4-dichlorophenol (DCP) were compared against phenol (P). Adsorption of P and CPCs on the particles ﬁt well the Langmuir isotherm. The adsorption capacities of P, CP, and DCP on SiO 2 particles with embedded MWCNTs were found to be 3.12, 13.83, and 44.25 mg/g, respectively. Desorption activation energy was determined by thermogravimetric analysis. Chlorine substitution on P changed the adsorption process from physical to chemical adsorption. The particles showed high potential for use as a pre-concentration unit for solid-phase microextraction.
The Impact of Trust and Recommendation Quality on Adopting Interactive and Non-Interactive Recommendation Agents: A Meta-Analysis

ABSTRACT Research on recommendation agents (RAs) originally focused on interactive RAs, which rely on explicit methods, i.e., eliciting user-provided inputs to learn about consumers’ needs and preferences. Recently, due to the availability of large amounts of data about individuals, the focus shifted toward non-interactive RAs that use implicit methods rather than explicit ones to understand users’ needs. This paper examined the differences between interactive and non-interactive RA types in terms of how they influence the impacts of two important antecedents of RA adoption, namely recommendation quality and trust on users’ cognitive and affective attitudes and behavioral intention. To that end, we developed a set of hypotheses and tested them empirically using a meta-analytic structural equation modeling approach. Our findings provide strong support for the influence of interactivity on RA users’ attitudes and cognitions. While we found that recommendation quality exerts a strong influence on consumers’ cognitive attitudes toward interactive RAs, this influence is statistically non-significant in the context of non-interactive RAs, in which recommendation quality mainly drives consumers’ affective attitudes toward the agent. Furthermore, while we found that cognitive attitudes exert a stronger influence than affective ones on consumers’ adoption of non-interactive RAs, our results indicate that the reverse is true with interactive RAs. Given the recent rise in the popularity of non-interactive RA tools, our results carry important implications for researchers and practitioners. Specifically, this study contributes to the extensive literature on consumers’ use of RAs by providing a better understanding of the differences between interactive and non-interactive RAs. For practitioners, the findings provide guidance for designers and providers of RAs on developing and improving RAs that are more likely to be adopted by consumers.
Arithmetic progressions of primitive roots of a prime. II.

In this note we generalize results, that were recently obtained in [4], concerning arithmetic progressions of primitive roots modulo a prime. Foremost, we are concerned now with arithmetic progressions of primitive roots of a prime that can be found in the classes of A-th power nonresidues of that prime. In addition, for primes of a certain form, we improve the results in [4] on sequences, of arbitrary length, of consecutive primitive roots. We state the following results.
Deep brain stimulation of the anterior nucleus of the thalamus for drug‐resistant epilepsy: Long‐term efficacy and outcomes from a prospective cohort

The anterior nucleus of the thalamus (ANT) has been one of the deep brain stimulation (DBS) targets for drug‐resistant epilepsy. This study aims to investigate the control of seizures among patients with ANT DBS for epilepsy. We have pioneered DBS for epilepsy in Hong Kong since 2015 and this study aims to report the long‐term outcomes from a prospective cohort.
A Novel Routing Protocol for Low-Energy Wireless Sensor Networks

The battery power limits the energy consumption of wireless sensor networks (WSN). As a result, its network performance suffered significantly. Therefore, this paper proposes an opportunistic energy-efficient routing protocol (OEERP) algorithm for reducing network energy consumption. It provides accurate target location detection, energy efficiency, and network lifespan extension. It is intended to schedule idle nodes into a sleep state, thereby optimising network energy consumption. Sleep is dynamically adjusted based on the network’s residual energy (RE) and flow rate (FR). It saves energy for a longer period. The sleep nodes are triggered to wake up after a certain time interval. The simulation results show that the proposed OEERP algorithm outperforms existing state-of-the-art algorithms in terms of accuracy, energy efficiency, and network lifetime extension.
Informal caregivers’ negative affect: The interplay of caregivers’ resilience, aging anxiety and burden

Abstract Objectives This study focused on the negative affect of informal caregivers of older adults. In a novel investigation, the interplay of aging anxiety, caregiving burden, and resilience as a protective factor was examined, suggesting that aging anxiety and caregiving burden are mediators for the link between resilience and negative affect. Methods In a cross-sectional design, 191 Israeli informal caregivers of older adults (65+) participated in the study. They completed questionnaires that assessed demographic and caregiving characteristics, resilience, aging anxiety, caregiving burden, and negative affect. Results The findings showed a serial mediation process in which higher resilience predicted lower caregiving burden, which subsequently predicted lower aging anxiety, which subsequently predicted lower negative affect. However, the indirect path from resilience to aging anxiety and negative affect was non-significant. Conclusion Based on this study’s findings, the aging anxiety of informal caregivers of older adults should be professionally addressed in the early stages of caregiving because it contributes to the caregiving burden and negative affect. Additionally, resilience should be enhanced by psycho-social interventions tailored to address informal caregiver challenges that often induce caregiving burden and negative affect.
Outcomes of COVID-19 Among High-Risk Individuals: A Study Comparing Febrile and Afebrile Presentation

Background Fever is one of the most frequent symptoms of coronavirus disease 2019 (COVID-19) and clinicians are faced with a practice question on whether fever is a risk for progression of disease especially in persons with risk factors for severe illness. We studied if a difference exists in the clinical course and outcome between febrile and afebrile (symptomatic) presentation. Methods Patients aged > 18 years with confirmed COVID-19 with at least one risk factor for severe illness were studied. Enrolment was done from a home COVID-19 care cohort between May 2020 and March 2022. Participants were divided into febrile and afebrile groups and further divided into six sub-groups based on their comorbidities (diabetes mellitus, hypertension, chronic lung disease, chronic kidney disease, liver disease and others) using a pre-specified inclusion method. Severity of illness was classified as non-hypoxic or hypoxic and clinical course was monitored. Results A total of 3,752 patients were studied, of whom 965 (25.7%) had severe illness and 117 (3.1%) died. Persons with obesity (P < 0.001), chronic kidney disease (P = 0.003) and chronic liver disease (P = 0.02) more frequently had presentation without fever. No significant difference in hypoxia (P = 0.35) or mortality (P = 0.50) was observed between febrile (n = 1,240) and afebrile (n = 2,512) presentation. Conclusion Fever in COVID-19 was not associated with severe illness or mortality. The overall and risk factor specific mortality observed in our study is substantially low, probably due to lesser bias in selection of study participants or due to ethnicity of study population.
Application of weighted Voronoi diagrams and randomization to variance-based k-clustering

In this paper we consider the k-clustering problem for a set S of n points pi = (~i) in the d-dimensional space with variance-based errors as clustering criteria, motivated from the color quantization problem of computing a color lookup table for frame buffer display. As the inter-cluster criterion to minimize, the sum of intracluster errors over every cluster is used, and as the int racluster criterion of a cluster Sj,
The Teachers’ Role in Behavioral Problems of Pupils With EBD in Special Education: Teacher–Child Relationships Versus Structure

This longitudinal study examined bidirectional associations between special education pupils’ teacher–child relationship characteristics (quality, satisfaction, and conflict), classroom structure, and behavioral problems (externalizing and attention-hyperactivity). A secondary goal was to investigate the extent to which severity of behavioral problems moderated the prospective associations. Participants were 586 pupils (86% boys) in Grades 4 to 6 (Mage time 1 = 10.82 years, SD = 0.86) from 13 special education schools in the Netherlands and their teachers. Findings indicated that primarily teacher–child conflict was related to increased externalizing problems. More classroom structure was related to decreased attention-hyperactivity problems, but higher teacher–child relationship quality was linked to increases in attention-hyperactivity problems. Moreover, both types of problems were related to increases in conflict. Severity of behavior problems did not moderate these associations. Although findings were not consistent in both school years, they suggested that particularly reducing conflict and instilling more classroom structure were the most effective strategies in reducing behavioral problems. Furthermore, disrupting negative transactional associations between conflict and externalizing behavior is important to reduce externalizing behavior.
Detection of extended-spectrum beta-lactamase genes in members of the Proteeae tribe isolated from a tertiary hospital in Southeast, Nigeria

Background: Tribe Proteeae consisting of Proteus, Providencia, and Morganella species are critical opportunistic pathogens causing various health care-associated infections. Widespread extended-spectrum β-lactamase (ESBL) activities have been reported among members of these groups of organisms. Aim: This study aimed to detect ESBL genes in clinical isolates of these bacteria from Nnamdi Azikiwe University Teaching Hospital (NAUTH). Materials and Methods: Two hundred and sixteen Gram-negative bacilli isolated from patients receiving care in NAUTH were identified using the Microbact 12A Gram-negative bacilli identification system. Antimicrobial susceptibility tests were performed on the isolates using antibiotics of various classes. The isolates resistant to any third-generation cephalosporins were screened for ESBL activity using the combination disc test. The presence of cefotaximase (CTX), oxacillinases (OXA), and transmission electron microscopy (TEM) genes were determined using polymerase chain reaction. Results: Out of the 216 Gram-negative isolates, 12 (5.6%) were Proteus spp. , 3 (1.4%) were Morganella spp. , and 8 (3.7%) were Providencia spp. The prevalence of the Proteeae bacteria was 23/216 (10.6%). Of the 23 Proteeae bacteria, 5 (21.7%) were confirmed phenotypically as ESBL producers, while 3 (13%) expressed the actual ESBL genes. CTX, OXA, and TEM genes were detected in all three isolates. Furthermore, 13% of the isolates exhibited carbapenem resistance. Conclusion: The results confirmed that ESBL-producing Proteeae bacteria existed in NAUTH. The incidental detection of carbapenem resistance among the Proteeae isolates whispers terror in waiting because carbapenems are last-resort antibiotics for managing life-threatening ESBL infections. This worrisome development highlights the need to improve infection control practices in Nigerian tertiary hospitals drastically.
DYNAMIC ANALYSIS OF DOLPHIN-STYLE THERMAL CROSS-COUNTRY FLIGHT

A dynamic computer study of sustained thermal cross country flight using the socalled dolphin technlques has been started. The thermal model allowed for the sinking zone surrounding the core. Preliminary results are showing the necessity of allowing for three different flight modes in the computer program. The best polnt for beginning the pull-up was found to be at some distance in advance of the therrmal core. Optimizing for the best normal load sequence in doing the pull-up and the push-down calls for more computer work. Relevant studies are going on and results will be compared with circling cross country flight performance calculations.
MORPHOLOGICAL SPECTRUM OF GASTRIC LESIONS-ENDOSCOPIC BIOPSY FINDINGS

Objective: A retrospective study was carried out to determine the morphological spectrum of gastric lesions at Pathology Department of Army Medical College, Rawalpindi for the duration of 02 years. Study Design: Descriptive Study. Patients and Methods: The gastric mucosal biopsies of 787 patients received from Gastroenterology unit of Military Hospital Rawalpindi from January 2002 to December 2003, were studied by routine histopathology methods. Results: A high frequency of gastric disease in males with a male to female ratio of 6:1 and an age range of 09 years to 85 years were observed. The clinical presentations mostly seen were abdominal pain, dyspepsia, vomiting, diarrhoea, decreased appetite and weight loss. On endoscopy the most frequently suspected lesions were gastritis 662(84.12%), stomach growth 45(5.72%), gastric ulcers 10(1.27%), while 70(8.89%) cases showed unremarkable mucosa. The histopathology revealed chronic non-specific gastritis 676(85.89%) followed by malignant tumours 45(5.72%), benign neoplasms 3(0.38%) and gastric ulcer 10(1.27%). A number of biopsies 53(6.73%) were unremarkable histologically. Conclusion: The more prevalent lesions in this series were chronic active gastritis followed by tumours and gastric ulcers. H. pylori associated gastritis was seen in majority of the patients. Thus gastric biopsy is an essential tool for diagnosis and confirmation of clinically
Lipid conjugation of TLR7 agonist Resiquimod ensures co-delivery with the liposomal 1 Cationic Adjuvant Formulation 01 (CAF01) but does not enhance immunopotentiation compared to non-conjugated Resiquimod+CAF01.

Pattern recognition receptors, including the Toll-like receptors (TLRs), are important in the induction 25 and activation of two critical arms of the host defence to pathogens and microorganisms; the rapid 26 innate immune response (as characterised by the production of Th1 promoting cytokines and type 1 27 interferons) and the adaptive immune response. Through this activation, ligands and agonists of TLRs 28 can enhance immunotherapeutic efficacy. Resiquimod is a small (water-soluble) agonist of the 29 endosome-located Toll-like receptors 7 and 8 (TLR7/8). However due to its molecular attributes it 30 rapidly distributes throughout the body after injection. To circumvent this, these TLR agonists can be 31 incorporated within delivery systems, such as liposomes, to promote the co-delivery of both antigen 32 and agonists to antigen presenting cells. In this present study, resiquimod has been chemically 33 conjugated to a lipid to form a lipid-TLR7/8 agonist conjugate which can be incorporated within 34 immunogenic cationic liposomes composed of dimethyldioctadecylammonium bromide (DDA) and 35 the immunostimulatory glycolipid trehalose 6,6’ – dibehenate (DDA:TDB). This DDA:TDB-TLR7/8 36 formulation offers similar vesicle characteristics to DDA:TDB (size and charge) and offers high 37 retention of both resiquimod and the electrostatically adsorbed TB subunit antigen Ag85B-ESAT6- 38 Rv2660c (H56). Following immunisation through the intramuscular (i.m.) route, these cationic 39 liposomes form a vaccine depot at the injection site. However, immunisation studies have shown that 40 this biodistribution does not translates into notably increased antibody nor Th1 responses at the 41 spleen and draining popliteal lymph node. This work demonstrates that the conjugation of TLR7/8 42 agonists to cationic liposomes can promote co-delivery but the immune responses stimulated with resiquimod conjugated to the liposome (DDA:TDB-Res). All results represent mean ± SD of 3 independent liposome batches.
DDDT_A_316110 3411..3423

1Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, 510370, People’s Republic of China; 2Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, People’s Republic of China; 3Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People’s Republic of China