Miracle-dz/UniFAR-FTUs huggingface dataset:
Machine Learning and Statistical Prediction of Pitching Arm Kinetics

Background: Over the past decade, research has attempted to elucidate the cause of throwing-related injuries in the baseball athlete. However, when considering the entire kinetic chain, full body mechanics, and pitching cycle sequencing, there are hundreds of variables that could influence throwing arm health, and there is a lack of quality investigations evaluating the relationship and influence of multiple variables on arm stress. Purpose: To identify which variables have the most influence on elbow valgus torque and shoulder distraction force using a statistical model and a machine learning approach. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A retrospective review was performed on baseball pitchers who underwent biomechanical evaluation at the university biomechanics laboratory. Regression models and 4 machine learning models were created for both elbow valgus torque and shoulder distraction force. All models utilized the same predictor variables, which included pitch velocity and 17 pitching mechanics. Results: The analysis included a total of 168 high school and collegiate pitchers with a mean age of 16.7 years (SD, 3.2 years) and BMI of 24.4 (SD, 1.2). For both elbow valgus torque and shoulder distraction force, the gradient boosting machine models demonstrated the smallest root mean square errors and the most precise calibrations compared with all other models. The gradient boosting model for elbow valgus torque reported the highest influence for pitch velocity (relative influence, 28.4), with 5 mechanical variables also having significant influence. The gradient boosting model for shoulder distraction force reported the highest influence for pitch velocity (relative influence, 20.4), with 6 mechanical variables also having significant influence. Conclusion: The gradient boosting machine learning model demonstrated the best overall predictive performance for both elbow valgus torque and shoulder distraction force. Pitch velocity was the most influential variable in both models. However, both models also revealed that pitching mechanics, including maximum humeral rotation velocity, shoulder abduction at foot strike, and maximum shoulder external rotation, significantly influenced both elbow and shoulder stress. Clinical Relevance: The results of this study can be used to inform players, coaches, and clinicians on specific mechanical variables that may be optimized to mitigate elbow or shoulder stress that could lead to throwing-related injury.
Dietary soluble non-starch polysaccharide level and xylanase influence the gastrointestinal environment and nutrient utilisation in laying hens

ABSTRACT 1. The objective of this study was to examine the influence of dietary soluble non-starch polysaccharide (sNSP) level and xylanase supplementation on productive performance, viscosity and pH along the gastrointestinal tract in laying hens. Excreta moisture content, ileal and caecal microbiota and short-chain fatty acid (SCFA) composition and apparent total tract nutrient utilisation were measured. 2. Hyline Brown laying hens (n = 144) were housed individually at 25 weeks of age and allocated to one of the four wheat-based dietary treatments in a 2 × 2 factorial arrangement, consisting of two levels of sNSP (High 13.40 g/kg or Low 11.22 g/kg), with or without xylanase (0 or 12,000 BXU/kg). Birds were fed the dietary treatments for 56 d. 3. Increasing dietary sNSP increased jejunum viscosity, degradability of total NSP, total tract flow of insoluble arabinose, and succinic acid concentration in the caeca (P < 0.05). Feeding high sNSP decreased excreta moisture content, total tract energy retention and free oligosaccharide, total tract flow of soluble and insoluble galactose and insoluble rhamnose and fucose, and ileal acetic and lactic acid concentrations (P < 0.05), and tended to reduce egg production (P = 0.058). 4. Supplementation with xylanase resulted in reduced jejunum and ileum viscosity, caecal pH, excreta moisture, flow of soluble arabinose and glucose and insoluble arabinose and xylose, caecal concentration of Lactobacillus sp. and isobutyric and succinic acid, and ileal concentration of Bacillus sp. and total anaerobic bacteria (P < 0.05). Xylanase application also increased energy retention and insoluble and total NSP degradation, and caecal abundance of Bifidobacteria sp. and valeric acid (P < 0.05). 5. These results reiterated the ability of xylanase to improve nutrient digestibility and reduce excreta moisture content in laying hens, and highlighted the importance of considering dietary sNSP level in laying hen diets.
Internet traffic growth: sources and implications

The high tech bubble was inflated by myths of astronomical Internet traffic growth rates. Yet although these myths were false, Internet traffic was increasing very rapidly, close to doubling each year since 1997. Moreover, it continues growing close to this rate. This rapid growth reflects a poorly understood combination of many feedback loops operating on different time scales. Evidence about past and current growth rates and their sources is presented, together with speculations about the future. The expected rapid but not astronomical growth of Internet traffic is likely to have important implications for networking technologies that are deployed and for industry structure. Backbone transport is likely to remain a commodity and be provided as a single high quality service. It is probable that backbone revenues will stay low, as the complexity, cost, and revenue and profit opportunities continue to migrate towards the edges of the network.
Encounters with Aircraft Vortex Wakes: The Impact on Helicopter Handling Qualities

A study concerning the risks associated with locating a helicopter final approach and takeoff area alongside an active runway at a busy international airport is documented. Specifically, by the use of desktop simulation, the problem is addressed of an in-flight helicopter encountering the shed wing tip vortex from a large transport aircraft. Measurements are reviewed of vortices taken using coherent laser radar equipment located under the final approach path to London Heathrow Airport to establish a model of the vortex velocity profile. The simulations have shown the helicopter can experience transient pitch attitude changes of up to 40 deg and accumulated descent rates of 1500 ft/min (457 m/min) during the encounter, assuming that no pilot intervention is made. Established handling qualities metrics have been adapted and suggest that these responses may produce handling difficulties. The simulations were also broadened to consider a range of helicopter designs and the effects of shed vortices from a number of large transport aircraft
Prolonged storage of purified granulocyte concentrates: Introduction of a new purification method

Use of donor granulocyte concentrate (GC) has been limited due to its short storage time of 6–24 h, which is partially due to residual red blood cells (RBCs) and platelets and the resulting lactate production leading to an acidotic milieu. To increase this storage time, we developed a closed system procedure compatible with standard blood bank technologies to remove RBC and platelets and to enrich the GC.
Patients’ experiences of a Communication Enhanced Environment model on an acute/slow stream rehabilitation and a rehabilitation ward following stroke: a qualitative description approach

Abstract Background Patients in hospital following stroke express a desire to continue therapy tasks outside of treatment activities. However, they commonly describe experiences of boredom and inactivity. An enriched environment aims to provide opportunities for physical, cognitive and social activity and informed the development of a Communication Enhanced Environment (CEE) model to promote patient engagement in language activities. Purpose Explore patient perceptions of a CEE model, and barriers and facilitators to engagement in the model. Methods A qualitative description study from a larger project that implemented a CEE model into acute and rehabilitation private hospital wards in Western Australia. Semi-structured interviews were conducted with seven patients, including four with aphasia, within 22 days post-stroke who had access to the CEE model. Results Patients described variable experiences accessing different elements of the CEE model which were influenced by individual patient factors, staff factors, hospital features as well as staff time pressures. Those who were able to access elements of the CEE model described positive opportunities for engagement in language activities. Conclusions While findings are encouraging, further exploration of the feasibility of a CEE model in this complex setting is indicated to inform the development of this intervention. Implications for rehabilitation Patient access to a CEE model is challenging in a hospital setting. Patients who were able to access elements of the CEE model described positive opportunities for engagement in language activities. Patients’ access to the CEE model was influenced by patient factors, staff factors, hospital features as well as staff time pressures.
Silencing FYVE, RhoGEF, and PH domain containing 1 (FGD1) suppresses melanoma progression by inhibiting PI3K/AKT signaling pathway

ABSTRACT Cutaneous melanoma is the leading cause of death among skin cancers despite the availability of diverse treatments. FGD1 plays an important role in multiple cancers, but how it works in cutaneous melanoma has not been illustrated. Thus, this study was intended to investigate the roles of FGD1 and its underlying mechanisms in cutaneous melanoma. Bioinformatics tools and quantitative real-time polymerase chain reaction (qRT-PCR) were used to analyze the expression of FGD1 in cutaneous melanoma. After the knockdown of FGD1 in melanoma cells, the proliferation, migration, and invasion of cells were analyzed by cell counting kit-8 (CCK8) assay, colony formation assays and transwell assays. Western blot was used to check the expression of key factors in PI3K/AKT pathway. In addition, nude mice models were used to study the role of FGD1 in melanoma development and metastasis in vivo. The data demonstrated that FGD1 was up-regulated and predicted a poor clinical outcome for cutaneous melanoma patients. Knockdown of FGD1 inhibited melanoma cell proliferation, migration, and invasion. The expressions of p-PI3K and p-AKT were significantly decreased, while the expressions of PI3K and AKT showed no marked difference in the knockdown group. Meanwhile, knockdown of FGD1 suppressed the development of melanoma in vivo. This study suggested that knockdown of FGD1 could block melanoma formation and proliferation by inhibiting PI3K/AKT signaling pathway. FGD1 might be a promising therapeutic target for melanoma.
The effect of reduced contact area on the occurrence of disc brake squeals for an automotive brake pad

Abstract Three sets of brake pads were subjected to a series of squeal tests. The pad area in contact with the brake disc was successively reduced down to 50 per cent of the original by removal of friction material either at the leading and trailing edges, at the outer and inner edges or spotwise removal of interior area by drilling. The pad surface geometry strongly affected the occurrence of brake squeals, with a significant reduction for all three pads with 50 per cent contact area. However, the average squeal noise level seems to be controlled by the pad contact length in the sliding direction.
Analysis of the stochastic error of stationary Monte Carlo device simulations

Without proper analysis of the stochastic error, it is not possible to assess the accuracy or efficiency of Monte Carlo device simulations, and misleading results might be obtained. This is demonstrated for the so-called variance-minimizing estimator for the steady-state terminal currents which turns out to be not more efficient than a standard estimator. Self-consistent (with respect to the electric field) and non self-consistent device simulations are analyzed. In contrast to previously published results both methods have the same efficiency with respect to terminal currents, but in the case of internal distributions, like the particle density, self-consistent simulations are much more efficient. In addition, it is shown that non self-consistency increases the relaxation times of fluctuations by orders of magnitude necessitating extremely long simulation times. The efficiency of statistical enhancement is found to be degraded by strong interparticle correlation due to particle splitting.
Role of Stirrups and Residual Tensile Strength of Cracked Concrete on Bond

The local bond‐slip law of an anchored ribbed bar after the splitting of its surrounding concrete is studied. Particular attention is devoted to understanding the reason why several experimental results show a different variability of this law along the bar. Actually, the bond is governed by the local confining action, which can vary; and its variability depends on both concrete mechanical properties and geometrical characteristics of the specimen. A significant contribution to this action is due to the transverse reinforcement and the residual tensile strength of splitted concrete. Another contribution is due to the structural characteristics, such as the transverse support restraints and possible lateral loads. A refined analytical model involving the local mechanical properties of concrete and the interaction phenomena between the principal and transverse reinforcement is developed. Experimental confirmations of the theoretical results are also presented. Finally, diagrams that are significant for desi.
Moderating effects of social support on the relationship between substance use disorders and HIV viral load and medication adherence among Black women living with HIV in the United States

ABSTRACT Substance use may predict lower rates of antiretroviral therapy (ART) adherence and viral suppression among Black Women Living with HIV (BWLWH). We assessed how perceived social support (PSS) moderates the relationship between substance use disorder (SUD) and viral load (VL) and ART adherence. 119 BWLWH provided information on PSS, SUD, alcohol use disorder (AUD) and adherence (via Wisepill). Higher PSS from friends (β = −.263, p = .008) and significant others (β = −.219, p = .025) predicted lower VL. SUD predicted low Wisepill adherence (a) in the past week (β = −.273, p = .035) and past two weeks (β = −.273, p = .033) only for women low in PSS from friends, and (b) in the past two weeks only for women low in total PSS (β = −.294, p = .024). Ironically, for women high in total PSS, SUD predicted higher adherence in the past four weeks (β = .360, p = .006). Adherence and VL may be bolstered by understanding the role of various forms of PSS and SUDs.
Breathing exercises versus strength exercises through telerehabilitation in coronavirus disease 2019 patients in the acute phase: A randomized controlled trial

Objective To compare the effectiveness of two different exercise-based programs through telerehabilitation in patients with coronavirus disease 2019. Design Randomized, controlled, parallel, double-blinded, three-arm clinical trial. Setting Patients’ homes through telerehabilitation devices. Subjects Subjects with coronavirus disease 2019 in the acute phase. Interventions Subjects were divided into three groups: breathing exercises group, strength exercises group or no treatment/control group. Main measures We analysed visual analogue scale for fatigue, 6-minute walking test, 30-seconds sit-to-stand test, multidimensional dyspnoea-12 questionnaire and Borg scale at baseline and 14 days later. Results From 93 subjects recruited, 88 were enrolled, and 77 patients (mean [SD] age 39.40 [11.71]) completed the 14-days intervention and were included in the analysis: 26 in strength exercises group, 29 in breathing exercises group and 22 in control group. The intergroup analysis shows significant differences between the study groups and control group in all variables (p < 0.05); Borg scale, multidimensional dyspnoea-12 questionnaire (pre–post intervention score: strength exercises group: 7.85 [6.82] – 4.54[4.82], breathing exercises group: 11.04 [6.49] – 5.32 [3.63], control group: 10.27 [6.49] – 10.59[6.58]), visual analogue scale for fatigue, 6-minute walking test and 30-seconds sit-to-stand test (pre–post intervention score: strength exercises group: 12.19 [4.42] – 13.58 [5.37], breathing exercises group: 11.18 [3.42] – 12.79 [4.00], control group: 10.45 [2.15] – 9.86[1.88]). The greatest effect sizes were found in the variables Borg Scale (R2 = 0.548) and multidimensional dyspnoea-12 questionnaire (R2 = 0.475). Conclusions Strength exercises group and breathing exercises group obtained significant improvements in fatigue, dyspnoea, perceived effort, and physical state, compared to control group, although the greatest benefits were found for dyspnoea and aerobic capacity in breathing exercises group.
Genomic prediction of the recombination rate variation in barley – A route to highly recombinogenic genotypes

Summary Meiotic recombination is not only fundamental to the adaptation of sexually reproducing eukaryotes in nature but increased recombination rates facilitate the combination of favourable alleles into a single haplotype in breeding programmes. The main objectives of this study were to (i) assess the extent and distribution of the recombination rate variation in cultivated barley (Hordeum vulgare L.), (ii) quantify the importance of the general and specific recombination effects, and (iii) evaluate a genomic selection approach’s ability to predict the recombination rate variation. Genetic maps were created for the 45 segregating populations that were derived from crosses among 23 spring barley inbreds with origins across the world. The genome‐wide recombination rate among populations ranged from 0.31 to 0.73 cM/Mbp. The crossing design used in this study allowed to separate the general recombination effects (GRE) of individual parental inbreds from the specific recombination effects (SRE) caused by the combinations of parental inbreds. The variance of the genome‐wide GRE was found to be about eight times the variance of the SRE. This finding indicated that parental inbreds differ in the efficiency of their recombination machinery. The ability to predict the chromosome or genome‐wide recombination rate of an inbred ranged from 0.80 to 0.85. These results suggest that a reliable screening of large genetic materials for their potential to cause a high extent of genetic recombination in their progeny is possible, allowing to systematically manipulate the recombination rate using natural variation.
Prevalence of Risk Factors of Non-communicable Diseases among Adolescents of a Rural Area in Darjeeling District of West Bengal.

INTRODUCTION Adolescence is the transitional period between childhood and adulthood when new health behaviors are laid down, which may track in to adulthood and have lifelong impact. Global trends show that these NCD-related behaviors are gradually rising among young people, and that they establish patterns of behavior that persist throughout life and are often hard to alter. OBJECTIVE To find out the prevalence and socio demographic predictors of risk factors of non communicable diseases among adolescents of a rural area Methods: A community based cross sectional study was conducted among 365 adolescents residing in a rural area of Siliguri subdivision. They were interviewed and measurements were taken using standard procedure. RESULTS The prevalence of behavioural factors for NCDs like tobacco use, alcohol use, unhealthy diet, physically inactivity was 18.4%, 4.7%, 87.1% and 23.0% respectively; metabolic risk factors like overweight, hypertension, and abdominal obesity 28.5%, 17.5%, 1.4% respectively. After adjustment, the odds of behavioural and metabolic risk factors were found highest among the males, participants whose mothers were not working and those who belonged to Hindu families and lower socioeconomic class. CONCLUSION The proportion of risk factors of non communicable diseases among the rural adolescents was quite high'. Given the associated health problems and costs, non communicable diseases have become an issue of serious concern.
Discontinued Use of the Loop Insulin Dosing System: A Mixed-Methods Investigation.

BACKGROUND Loop is an open-source automated insulin dosing system that allows users unrivaled control over system settings that effect future glucose prediction. Thousands use Loop, but little is known about those who discontinue. METHODS In a large observational study, 874 Loop participants completed surveys and provided glycemic data, 46 (5.3%) of those self-identified as discontinuing Loop during the observation window, 45 completed a discontinued use survey, 22 provided system settings data, and 19 participated in semi-structured interviews about their discontinuation. Qualitative data were transcribed, coded, and analyzed. RESULTS Older age and not trusting Loop were associated with discontinued use, though no other demographic or clinical characteristics were significant correlates. The most endorsed reasons were "I decided to try something else" (27.8%) followed by "It just didn't help as much as I thought it would" (22.2%). Qualitative analyses revealed prominent themes centered upon mental and emotional burden and adjusting settings. Other reasons for discontinued use included: fear of disapproval of Loop use from diabetes provider, barriers to acquiring component devices, a desire to try new/different technologies, concerns that Loop could not accommodate specific exercise or low insulin dose regimens, and worry about Loop use during pregnancy. It was noted that burdens might be alleviated by enhanced technical assistance and expert guidance. CONCLUSIONS While the majority of individuals in the Loop observational study continued use, those who discontinued reported similar challenges. Technical support and education specific to setting calculations could expand Loop benefits, alleviate burden, and support sustained use among new Loop users.
Recent progress in the hard-tube MILO experiment

The Hard-Tube MILO (Magnetically Insulated transmission Line Oscillator) is a gigawatt-class L-band high power microwave tube driven by a 500 kV, 60 kA electron beam. It is nearly identical to the MILO reported by Calico et al., with the principle difference being that the Hard-Tube MILO has been constructed using conventional-tube brazing techniques for the rf joints, while the earlier version of MILO used finger-stock connections for the rf joints. This paper reports on recent experimental improvements to the tube that have allowed us to generate 1.5 - 2.0 GW pulses of 175 ns duration; a 2.5 times improvement in the pulse width over the original tube. In addition, we report on experiments to identify the breakdown mechanism in the vacuum radome for the Vlasov antenna used to radiate the microwave pulse. Finally, details of an optimized version of the Hard-Tube MILO that should allow us to generate over 3.0 GW are presented.
Association of SARS-CoV-2 Infection With Psychological Distress, Psychotropic Prescribing, Fatigue, and Sleep Problems Among UK Primary Care Patients

Key Points Question Is SARS-CoV-2 infection associated with risk of subsequent psychiatric morbidity, sleep problems, or fatigue? Findings In this cohort study of the health care records of 11 923 105 patients, including 226 521 patients with SARS-CoV-2 infection, while infection was associated with increased risk of sleep problems and fatigue, associations with subsequent psychiatric morbidity were mixed. Meaning These findings suggest that psychiatric morbidity associated with SARS-CoV-2 infection may be overstated in analyses of health care records that do not sufficiently control for confounding.