Miracle-dz/UniFAR-FTUs huggingface dataset:
Antipsychotic Polypharmacy and High Doses in a Rural Portuguese Community Mental Health Service

Introduction: Antipsychotic polypharmacy (APP) and high dose (APHD) remain a common practice in the treatment of severe mental illness, even though they are not supported by current international guidelines. Methods: We aimed to establish the prescribing patterns of antipsychotics in a community mental health service in a rural setting, to determine the prevalence of APP and APHD treatment and to identify associated factors. Results: We identified 284 patients. APP was present in 46.5% patients and was associated to younger age, single status, more previous psychiatric admissions, and anticholinergic prescription. Prescription of APHD was observed in 14.4% patients and was associated with previous inpatient admissions, being prescribed with a first generation long‑acting injectable antipsychotic and anticholinergics. We also found that APP and APHD were mutually associated. Conclusion: Despite current guidelines, we found prevalences of APP and APHD of 46.5% and 14.4%, respectively. Further studies are necessary to better evaluate the antipsychotic prescription patterns in Portugal.
DMSO_A_310091 3841..3849

1Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; 2Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia Purpose: National formulary restrictions in Indonesia (2019) require estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m to be able to prescribe telmisartan and valsartan and ACE-I intolerance to be able to prescribe irbesartan and candesartan. These restrictions are based on economic considerations and differ from American Diabetes Association (ADA) (2020) guidelines which allow equal use of angiotensin II receptor blockers (ARB) and angiotensin-converting enzyme inhibitors (ACE-I) without restriction. Since there is a need to evaluate the different effects of ACE-I and ARB in the Indonesian hypertensive type 2 diabetes mellitus (T2DM) population, we compare their effects on urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and blood potassium level. Patients and Methods: A prospective cohort study at RSUPN Dr. Cipto Mangunkusumo Hospital was conducted in 123 T2DM patients. We followed the study subjects prospectively for three months using a validated questionnaire, health record, and laboratory data. Results: After 3 months of observation, there were no significant changes, except increased BMI values (p = 0.046) in the ACE-I group, and decreased LDL value (p = 0.016) and HDL value (p = 0.004) in the ARB group. Multivariate analysis showed that the consumption of ACE-I or ARB was not associated with a decrease/constant of UACR or increase potassium level, even after adjusting by confounding variables. Interestingly, we found ARB was more likely to increase eGFR, but the significance was lost once the duration of ACE-I/ARB use was entered into the model. In addition, BMI >25 kg/m was a significant factor associated with decreased/constant UACR, maleness was significant for increased eGFR, and declining systolic blood pressure for increase in potassium level. Conclusion: ACE-I and ARB have a similar effect on UACR and blood potassium level, but ARB slightly increased eGFR compared to ACE-I within three months of consumption.
Nutritional composition, antioxidant assay and α-glucosidase inhibitory flavonoids from the fruits of Carissa edulis Vahl (Apocynaceae)

Carissa edulis Vahl (Apocynaceae) is a plant whose leaves, roots and fruits are traditionally employed for the treatment of malaria, microbial infections, headache, cough, fever and ulcer among many others. Fresh fruits of Carissa edulis were crushed and extracted with 70 % methanol for 72 hours to obtain MeOH extract. Proximate analysis as well as mineral composition of the fresh fruits were determined. Total phenolic content (TPC), total flavonoids content (TFC) and antioxidant activity (DPPH, FRAP & Ferrous chelating) of the MeOH extract were determined, while the α-glucosidase inhibitory activity of the extract was conducted using bioautographic assay. The structure of compounds isolated were elucidated by 1D NMR spectroscopic analysis and high-resolution mass spectrometric (HRESIMS) data. The results showed that the nutritive value of the fresh Carissa edulis is 43.43 kcal/100 g, while the extract demonstrated good antioxidant activities (DPPH, IC50 = 87.98 μg/ml; FRAP, EC50 = 464.33 μg/ml & Ferrous chelating, EC50 = 294.55 μg/ml). Further study of the MeOH extract of the fruit led to the isolation of rhamnetin-3-β-D-glucopyranoside, peonidin-3-rutinoside and malvidin-3-O-β-D-(6”-acetylglucoside). These results suggest that the fruits of Carissa edulis are nutritious and possess potential antidiabetic effect which corroborated the ethnomedical uses of the fruits. Keywords: Carissa edulis; α-Glucosidase; Anthocyanins; Nutritional composition; Antioxidant properties
PHMT_A_322069 467..479

1Clinical Midwifery, Department of Midwifery, College of Medicine and Health Science, MizanTepi University, Mizan, Ethiopia; 2Clinical Pharmacy, School of Pharmacy, Institute of Health, Addis Ababa University, Addis Ababa, Ethiopia; 3Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Science, MizanTepi University, Mizan, Ethiopia Introduction: Neonatal sepsis is the gravest problem in neonates, ending in significant morbidity and mortality. World wide 6.9 million neonates were spotted with potentially severe bacterial infections needing treatment and 2.6 million of them occurred in subSaharan Africa (SSA). Sepsis is the leading cause of neonatal mortality and is perhaps answerable for about 30–50% of the total neonatal deaths per year in emerging countries. Objective: This study aims to assess the treatment outcome and associated factors of neonatal sepsis at Mizan Tepi University Teaching Hospital, South West Ethiopia. Methods: A hospital-based prospective observational study was done at Mizan Tepi University Teaching Hospital (MTUTH) from May to November 2019 among neonates admitted with sepsis. Data were entered to Epi-data 4.2 and analyzed by SPSS version 21. Bivariate and multivariate Cox regression was used to identify the relationship between dependent and independent variables. All neonates ≤28 days who were admitted to MTUTH at the neonatal intensive care unit (NICU) and neonates diagnosed with sepsis by the attending physician either clinically or laboratory-confirmed included in the study. Results: Of the 211 neonatal sepsis patients, 110 (52.1%) were females, 161 (76.3%) were admitted with late-onset sepsis, 16 (7.6%) were very low birth weight, and 156 (73.9%) were term. About 143 (67.8%) had a good outcome and 68 (32.2%) had a poor outcome. Very low birth weight [P = 0.006, AHR = 1.692, 95% CI: (1.245, 4.36)], age of neonate being less than 4 days at admission [P = 0.001, AHR = 9.67, 95% CI: (2.24, 41.70)], maternal infection [P = 0.032, AHR = 3.186, 95% CI: (1.32, 30.68)], and prolonged length of hospital stay [(P = 0.017, AHR = 12.29, 95% CI: (1.55, 96.31), were significantly associated to mortality. Conclusion: The mortality rate of neonatal sepsis was found to be high. Age of neonate <4 days, birth weight of the neonate <1500 gm, and prolonged length of hospital stay were identified as independently associated factors of increased risk of mortality.
Liposome Extract of Stachys pilifera Benth Effectively Improved Liver Damage due to Bile Duct Ligation Rats

Herbal medicines harbor essential therapeutic agents for the treatment of cholestasis. In this study, we have assessed the anticholestatic potential of Stachys pilifera Benth's (SPB's) hydroalcoholic extract encapsulated into liposomes using bile duct ligation- (BDL-) induced hepatic cholestasis in rats. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), malondialdehyde (MDA), total thiol (T-SH) content, protein carbonyl (PCO), total bilirubin (TBIL), albumin (ALB), and nitric oxide (NO) metabolite levels were measured in either liver tissue or plasma to assess liver damage. Moreover, expression of proinflammatory cytokines (IL-1β and TNF-α) and liver fibrosis markers (TGF-β and SM-α) which are driving forces of many liver disorders was also determined. The activity of AST, ALT, and ALP was significantly enhanced in the BDL group in comparison to the control group; however, treatment with liposomal (SPB) hydroalcoholic extract significantly reduced AST and ALT's activity. Increases in MDA, TBIL, and NO levels and T-SH content due to BDL were restored to control levels by liposomal (SPB) hydroalcoholic extract treatment. Similarly, hepatic and plasma oxidative marker MDA levels, significantly enhanced by BDL, were significantly decreased by liposomal (SPB) hydroalcoholic extract treatment. Moreover, histopathological findings further demonstrated a significant decrease in hepatic damage in the liposomal (SPB) hydroalcoholic extract-treated BDL group. In addition, liposomal (SPB) hydroalcoholic extract treatment decreased the liver expression of inflammatory cytokines (IL-1β, TNF-α) and liver fibrosis markers (TGF-β and SM-α). Since liposomal (SPB) hydroalcoholic extract treatment alleviated the BDL-induced injury of the liver and improved the hepatic structure and function more efficiently in comparison to free SPB hydroalcoholic extract, probable liposomal (SPB) hydroalcoholic extract exhibits required potential therapeutic value in protecting the liver against BDL-caused oxidative injury.
The Upregulation of COX2 in Human Degenerated Nucleus Pulposus: The Association of Inflammation with Intervertebral Disc Degeneration

Intervertebral disc degeneration (IVDD) is an important risk factor of low back pain. We previously found upregulated markers of fibrosis, the late stage of chronic inflammation, in degenerated IVD with a small number of clinical specimens. Here, we aimed to study on a larger scale the association of cyclooxygenase 2 (COX2), an inflammation and/or pain marker, with IVDD. This study involved 107 LBP participants. The IVD degeneration level was graded on a 1–5 scale according to the Pfirrmann classification system. Discs at grades 1-3 were further grouped as white discs with grades 4-5 as black discs. We recorded baseline information about age, gender, body mass index (BMI), diabetes history, smoking history, and magnetic resonance imaging (MRI). Their association with IVDD was statistically analyzed. The expression level of COX2 was investigated by immunohistochemistry. The total integrated COX2 optical density (IOD), number of COX2-positive cells, and total cell number of each image were counted and analyzed by Image-Pro Plus software. The IOD and number of COX2-positive cells were divided by the total cell number to obtain COX2 expression density (IOD/cell) and COX2 positivity (cell+/cell). As a result, among the baseline information investigated, only age was found to have a significant association with IVDD. The IOD/cell was found to be significantly increased from grade 2 to grade 5, as well as in black discs compared to white discs. The cell+/cell displayed the same trend that it increased in highly degenerative discs compared to their counterparts. In conclusion, the expression of COX2 is associated with IVDD, which highlights COX2 as a biomarker for IVD degeneration and indicates the involvement of inflammation and pain signaling in IVDD.
MODER ATING EFFEC T OF INSTITUTIONAL QUALIT Y ON REL ATIONSHIP BE T WEEN FOREIGN AID AND ECONOMIC GROW TH IN AFRICA

1a Africa has received considerable amounts of external aid over the last two decades without significant improvements in socio-economic conditions on the continent. This study, therefore, examines the effects of foreign aid on growth in Africa, and how institutional quality can moderate these effects. The study used the system generalized method of moments estimation technique and a panel of forty-two African countries over the period 2010–2018. Interestingly, the study established that even though foreign aid impacts negatively on growth in Africa, improving the quality of institutions on the continent can reverse this negative effect. In fact, the study computed a threshold value of institutional quality beyond which foreign aid would be a blessing to Africa. This implies that for foreign aid to contribute meaningfully to growth in Africa, the quality of institutions should improve beyond this threshold. Unfortunately, the average level of institutional quality in Africa is presently below this threshold. The study concluded that policymakers in Africa should take urgent steps to strengthen the quality of institutions on the continent as a means of exploiting the continent’s huge foreign aid to drive growth and reduce the excruciating effects of poverty plaguing more than half of its population.
Social Media Adoption in Yemeni Local NGOs

Social media use is rapidly increasing as its platforms keep offering excellent opportunities for individuals and organizations, including NGOs, to develop better outreach with communities, donors and stakeholders, save costs and improve service. This study explores quantitative evidence derived from a survey involving 96 participants from 11 local NGOs in Yemen. The survey responses are analyzed using descriptive statistics that includes means and standard deviations to examine the initially identified 6 Technology-Organization-Environment factors (Technological Factors: perceived benefit, compatibility, complexity; Organizational Factor: top management support; Environmental Factors: bandwagon pressure and competitive pressure). The results suggest that the factors (perceived benefit, compatibility, complexity, top management support, and competitive pressure) are important for social media adoption. It was found that bandwagon pressure is the only factor that does not have a significant role in social media adoption. This study provides a foundation for future social media adoption research as well as useful guidance to NGOs that desire to use social media effectively to benefit their organizations. The findings can be useful to managers and communication officers of NGOs. In this study, it is recommended that understanding the factors related to adoption of social media by Local NGOs will help decision-makers be in a better position to enhance future social media adoption and adoption strategies and accomplish the best outcomes of social media utilizations.
Exploring the Experiences of Postgraduate Students in the Field of Special Education with Remote Online Teaching Amid COVID-19 Pandemic: A Mixed Methods Study

The spread of COVID-19 has had a significant impact on many parts of life, including education. Instructors, students, and institutions across the world were forced to close their doors and shift to online distance learning in accordance with the World Health Organization (WHO) recommendation for social distancing. This study aims to explore the experience (challenges and benefits) of Saudi postgraduate students in the field of special education relating to the sudden shift to online distance learning during the COVID-19 pandemic. An embedded mixed methods design with a great emphasis placed on the qualitative strand, while the quantitative strand took a secondary role. Online learning readiness was assessed using a scale with (n=37) postgraduate students, then interviews were conducted with (n=9) postgraduate students. Postgraduate students in the Kingdom Saudi Arabia were found to have a high level of readiness and were highly confident and highly motivated for online learning during the pandemic. The most frequently mentioned challenges found in this study included technical difficulties. It was also found that despite the challenges faced by the students, they still preferred virtual classes over traditional face-to-face lectures, as they are flexible and convenient. Study results lead to a better understanding of postgraduate students’ adaptation to online learning in emergency situations. Additional improvements including refining the difficulties, strengthening the current advantages, and listening to students’ experiences and suggestions would lead to more successful remote teaching in the future. Received: 12 July 2021 / Accepted: 20 August 2021 / Published: 5 September 2021
Nitrogen response and agronomic use efficiency of N fertilizer in diverse commercial maize hybrids at Bako, Western Ethiopia

Agronomic Effi ciency indicated the grain yield production potential of variety in response to the applied nutrients. Field experiment was conducted at the research Farm of Bako National Maze Research Center Western Ethiopia during 2020/2021 in order to investigate the nitrogen response and agronomic effi ciency of various maize genotypes. Ten maize varieties were tested under two level of nitrogen (N1 = 0 kg/ha and N2 = 184 kg/ha) in factorial arrangement with three replications. Each variety was planted in uniform spacing of 75x30 cm. Then response of each variety for the applied nitrogen were evaluated. Agronomic effi ciency of Nitrogen Fertilizer associated with grain yield of various commercial maize varieties was calculated using average grain yield and applied nitrogen to indentify the agronomic effi ciency of each maize varieties. Based on calculation result maize hybrid BH661 showed the highest agronomic effi ciency (35.42), where as Gibe3 showed the lowest value (4.68) compared to others tested varieties. This result indicated that Gibe3 respond poorly for the applied nitrogen where as Hybrid BH 661 highly responded for the increasing applied N input. The result has indicated the need of specifi c recommendation for nutrient scarce area, that lack nitrogen or for farmers who lacks money to buy nitrogen fertilizer should be used Gibe3 to get better yield. On other hand in optimum or high nitrogen available condition the hybrids which have high agronomic effi ciency should be sown to boost maize grain yield but with taking into account the optimum rain fall and agro ecology of each variety. Research Article Nitrogen response and agronomic use effi ciency of N fertilizer in diverse commercial maize hybrids at Bako, Western Ethiopia Begizew Golla* Bako National Maize Research Center, Ethiopian Institute of Agricultural Research, P. O. Box 2003, Addis Ababa, Ethiopia Received: 29 July, 2021 Accepted: 21 August, 2021 Published: 24 August, 2021 *Corresponding author: Begizew Golla, Bako National Maize Research Center, Ethiopian Institute of Agricultural Research, P. O. Box 2003, Addis Ababa, Ethiopia, E-mail:
Evaluation of the Efficacy of Coenzyme Q10 in the Management of Chronic Periodontitis: A Clinical Study

Abstract Aim The present study was aimed to clinically evaluate the effectiveness of coenzyme Q10 (CoQ10) in the management of chronic periodontitis. Materials and Methods A total of 60 patients aged between 30 and 60 years with bleeding on probing and probing pocket depth (PPD) of 3 to 5 mm were selected and divided into three groups, with group I receiving scaling and root planing, group II CoQ10 formulation for 6 weeks, and group III receiving both scaling and root planning, followed by coenzyme Q10 administration for 6 weeks. PPD, relative attachment level (RAL), and gingival index were recorded in all the groups at baseline, 6 weeks, and 3 months, respectively. The data was statistically analyzed using Kruskal–Wallis, Mann–Whitney, and Wilcoxon signed rank tests. Result Intragroup comparison showed statistically significant difference (p ≤ 0.05) between the clinical parameters of all the groups at all time intervals, whereas intergroup comparison of all the parameters showed high statistically significant difference (p ≤ 0.001) in group III at various time intervals followed by group I and group II. Conclusion It was concluded from the study that CoQ10 is a useful adjunct in treating chronic periodontitis by boosting the host resistance to periodontal disease.
Awareness and Contribution of African Indigenous Leafy Vegetables to Household Wellbeing: A Case of Smallholder Farmers in Kisii County, Kenya

This study investigated the contribution of African Indigenous Leafy Vegetables (AILVs) to the welfare of smallholder farmers in Kisii County. AILVs have recently been attracting research attention not only in terms of their inherent nutrition quality and healing properties but also for their economic potential that is brought about by increased consumer demand of these vegetables. Despite having multiple benefits and positive promise towards contributing to household food dietary quality and income, utilization of African indigenous Leafy Vegetables (AILVs) by farming households is still low as indicated by a constant deficit in supply. Based on the claimed benefits in the face of low volumes in terms of utilization, this study sought to examine the socioeconomic characteristics of AILVs smallholders and factors that influence production of these vegetables in Bomachoge Borabu Sub-County, Kisii County Kenya. A Multistage sampling method was used to obtain a sample of 150 AILV farmers. Questionnaires were used to collect the data. Descriptive statistics were used to characterize the socio-economic characteristics while Tobit model was utilized in analyzing the factors that influence production of AILVs. The Tobit regression results indicated that age, gender, education, value awareness, occupation and household income significantly influenced AILV production. The study concluded that engagement in AILVs utilization brings along unmatched benefits. The study recommends a long term campaign majorly targeting the young and the non-growing communities in creation of value awareness to improve on the utilization of the vegetables. The study also recommends a similar study in regions of the Country that record low levels of utilization.
Identifying Major Research Areas and Minor Research Themes of Android Malware Analysis and Detection Field Using LSA

Contemporary technologies have ensured the availability of high-quality research data shared over the Internet. This has resulted in a tremendous availability of research literature, which keeps evolving itself. Thus, identification of core research areas and trends in such ever-evolving literature is not only challenging but interesting too. An empirical overview of contemporary machine learning methods, which have the potential to expedite evidence synthesis within research literature, has been explained. This manuscript proposes Simulating Expert comprehension for Analyzing Research trends (SEAR) framework, which can perform subjective and quantitative investigation over enormous literature. TRENDMINER is the use case designed exclusively for the SEAR framework. TRENDMINER uncovered the intellectual structure of a corpus of 444 abstracts of research articles (published during 2010–2019) on Android malware analysis and detection. The study concludes with the identification of three core research areas, twenty-seven research trends. The study also suggests the potential future research directions.