Miracle-dz/UniFAR-FTUs huggingface dataset:
The Preventive Effects of N-Acetylcysteine on Tacrolimus Induced Nephrotoxicity

Tacrolimus exhibits its nephrotoxic effect in relation to its inhibition of one of the antioxidant enzymes named catalase. Glutathione peroxidase catalysesa similar reaction done by catalase. The factor which increases GPx’s activity is Glutathione levels.Subsequently, Glutathione levelsare increased by N-Acetyl cysteine (NAC). Thus, it seems NAC can influence the prevention of Tacrolimus mediated nephrotoxicity. In this study,Sprague-Dawley ratsreceived1 mg/kg/day dose of tacrolimus in the control group while the three treatment groupsreceived 1mg/kg/day of tacrolimuswith NAC in 100,200 and 300 mg/kg/day doses respectivelyfor 28 days. Upon study completion, the biochemical markers of tacrolimus nephrotoxicity (urinary microalbumin,serum creatinine and BUN) showed dramatic increase in both the control group and in the three treatment groups. Urinary microalbumin levels showed significant decrease with 300 mg/kg NAC dosing (p<0.01). Furthermore, serum creatinine levels showed significant decrease in all three doses (p<0.05) while BUN showed significant decrease in NAC 100 and 200 mg/kg doses (p<0.01) and 300 mg/kg dose (p<0.001). In the control group on tacrolimus alone, an increase in interstitial fibrosis and tubular atrophytwo important markers of chronic tacrolimus nephrotoxicitywas observedwhereas in contrastthe NAC treatment groups revealed a significant decrease in interstitial fibrosis (p<0.05 in NAC 200 and 300) and tubular atrophy (p<0.05 for NAC 200 and 300). These findings confirm the nephroprotective effects of N-acetylcysteine in chronic tacrolimus nephrotoxicity which acts in a dose dependent manner.
Application of Computational Method for Quantitative Analysis of Protein Expression of P16ink4a in Cervical Biopsies through Immunohistochemistry

Introduction: The purpose of this study was to standardize the quantification of protein expression of p16INK4a in cervical biopsies using computational method, and to compare it with methods used previously, as well as with HPV viral subtypes, aiming to establish an methodology for cervical biopsies. Material and Methods: Fifty-eight cases of Pap slides and cervical biopsies were selected. Then, immunohistochemistry for p16INK4a in cervical biopsies and quantitative analysis using the software Image J were performed. The interpretation was performed using the Richart system, German Scoring, and a qualitative method. A genotyping for HPV was performed. Results: A significant association between quantification by Image J software and Richart system, German Scoring System, and qualitative method (p <0.05, p <0.001) was observed. When comparing the results obtained with high and low risk viral subtypes, and negative samples, a proportional and significant association (p<0.001) was also observed; when comparing the results with the viral subtypes separately, a significant correlation between genotypes 16, 18, 33, 39, 52, 58, and 73 (p<0.05, p<0.001) was reported. Discussion: A proportional correlation of p16INK4a quantification and Richart, German Scoring, and qualitative method scores, as well as with different viral genotypes was observed. Currently, the evaluation systems show deficiencies due to diagnostic interor intrapersonal variations. We suggest that the quantification of p16INK4a in cervical biopsies by Image J software shows significant results for improving diagnostic techniques of cervical cancer, which may help in effectively choosing a clinical treatment without interor intrapersonal variations.
21-03-2015 ISSUES Kin-pdfMachine from Broadgun Software, http://pdfmachine.com, a great PDF writer utility!

Enzymatically active chitinases chitotriosidase (CHIT-1) and AMC-ase as well as Chitinase Like Proteins YKL-40, YKL-39 have specific patterns of association with immune response. Serum levels of CHIT-1 and YKL-40 mainly reflect the activation status of macrophages, and in particular lipid-laden macrophages. While chitotriosidase is a specific marker for lysosomal storage disorders, overexpression of YKL-40 was found in numerous of tumors, chronic and acute inflammations and during fibrosis progression. We compared the Chitinases variations during the differentiation and polarization of human macrophages. Gene expression analysis was investigated by real-time PCR from mRNA of human monocytes obtained from buffy coat of healthy volunteers, polarized to classically activated macrophages (or M1), whose prototypical activating stimuli are Interferon-gamma and lipopolysaccharide, and alternatively activated macrophages (or M2) obtained by interleukin-4 exposure. We found that CHIT-1 and YKL-40 were significantly modulated throughout monocyteto-macrophage differentiation and polarization. In contrast, AMC-ase, YKL-39 showed slight modulation in the diverse stage of macrophages differentiation and/or polarization. In conclusion our results show that the expression of CHIT-1 AMC-ase, YKL-40 and YKL-39 is differentially regulated throughout monocyte-to-macrophage differentiation and polarization. Our finding suggests that whereas the immune function of AMC-ase and YKL-39 is restricted and selective, CHIT-1 and YKL-40 are protagonists in innate and acquired immunity.  2015 Trade Science Inc. INDIA Regular Paper
IMPACT OF SOCIAL MEDIA ON FOREIGN ARTISTS’ E-ART PROMOTION

Received: 31 Mar. 2016 Accepted: 24 Jul. 2016 Revised: 11 Oct. 2016 Published: 10 Dec. 2016 ABSTRACT: The emergence of social networking sites has made it possible for artists to interact with many social media users and to communicate as well as promote their artworks among art lovers. The objective of this paper is to investigate the impact of social media marketing (SMM) activities on foreign artists‘ E-art promotion in India. The constructs were adapted from an extensive review of prior empirical studies on social media and E-art promotion. The data were collected through a survey from the Facebook users those who liked or joined foreign artists‘ Facebook pages. A questionnaire using Likert scale was used to collect the data. Exploratory factor analysis was used to identify the relevant five constructs of SMM activities: customization, entertainment, trendiness, word of mouth, and interaction. Structured equation modeling was performed to analyze the data. Results indicate that SMM activities had positive and significant effects on E-art promotion mix elements. `
Customers’ motivation to adopt digital banking: A case study of HDFC Bank in Kolkata

The Indian banking sector is undergoing a radical change from branch banking to digital banking. Both public and private banks in association with government are presently carrying out intense campaign to bring the users of banking system under digital banking process. However, while over the last few years a large section of the customers have adopted digital banking, many are still reluctant to do so. Therefore, to achieve results, it is imperative to understand the motivations underlying the consumers’ adoption of digital banking. This study aims to contribute towards this end to some extent. In this study, the motivations towards adopting digital banking were identified in case of four branches of HDFC Bank in Kolkata. The findings depict that net banking is primarily used for making various enquiries, online purchases and money transfer. The identified reasons why many customers have not adopted digital banking till today include non-awareness and ignorance regarding the digital banking procedures, skepticism regarding security aspect, reluctance to change long-time habit of manual banking and utilizing branch banking to socialize and pass time in case of retired persons.
Development of DC voltage control from wind turbines using proportions and integrals for three-phase grid-connected inverters

This research article presents the method to control the DC voltage of the boost converter by using a proportional-integral (PI) controller. With AC voltage from a wind turbine generator, converting to DC voltage level by rectifier, this DC voltage controlled by PI controller is to control boost converter that sends DC links to the inverter which converting alternating current voltage to direct current voltage through three-phase load and to the grid-connected system. For switching the IGBTs in the inverter, the PWM signal, on the hysteresis current control, is controlled by the signal from the detected reference voltage based on the grid-connected system and the voltage from a wind turbine generator. The tests made the comparison of results from the simulation with the MATLAB/Simulink program and result from the hardware on the prototype. The power quality results, such as harmonic, power factor, are in acceptable ranges.
DETERMINANTS OF PROFITABILITY IN COMMERCIAL BANKS OF INDONESIA AN EMPIRICAL STUDY

This study aims to determine the factors that affect the profitability of commercial banks in Indonesia. This research is a quantitative research using a sample six largest banks with total assets under ICMD. The banks included in the sample in this study is that Bank Mandiri (Persero) Tbk. , Bank Rakyat Indonesia (Persero) Tbk. , Bank Central Asia Tbk. , Bank Negara Indonesia (Persero) Tbk. , Bank Danamon Indonesia Tbk. , and Bank Pan Indonesia Tbk. The research data in the form of panel data obtained from the annual financial statements of the bank. Techniques using multiple linear regression analysis. The results showed that the variables of liquidity of banks, non-performing loans and capital adequacy simultaneously affect the bank's profitability. The partial effect of liquidity and nonperforming loans significantly influence the profitability of banks. While the capital adequacy ratio of no significant impact on the profitability of commercial banks in Indonesia.
International Journal of Scientific Research in Computer Science, Engineering and Information Technology

The proper using of FMEA method is proven to reduce the cycle of warranty costs and will certainly cost less to prevent than to fix the problems that have already occurred. FMEA also was suitable for assessing risk in information technology or systems aspect. Several studies criticized the FMEA limitation or weakness of using this method. The purpose of this paper is to provide a resume and critical analysis of previous research that discussed the development and limitation of FMEA. A systematic literature review methodology was conducted in order to review FMEA. As a result, 32 papers were obtained in the selection stage according to the criteria used and review based on quality content. Data collection and identification stage was carried out by the selected papers for further analysis and synthesis. The limitation FMEA was due to the subjectivity and caused inconsistent results. This paper provided the critical analysis about the point of weakness FMEA based on document FMEA, and also limitation FMEA based on risk management process. There were eight research questions that could be considered from the results. By conducting a literature review of the development and trending of FMEA research, it provided new research opportunities to proved the FMEA issues reviewed in this paper.
COMPARISON OF EMPIRICAL MODELS FOR ESTIMATING THE MINERALIZATION POTENTIAL OF SOIL ORGANIC NITROGEN

1189 | P a g e D e c e m b e r 2 0 1 7 h t t p s : / / c i r w o r l d . c o m COMPARISON OF EMPIRICAL MODELS FOR ESTIMATING THE MINERALIZATION POTENTIAL OF SOIL ORGANIC NITROGEN Zoubeir BENSID, Mahtali SBIH , Djenette CHERGUI , Ghaouti KERRACHE , 1 Institute of Veterinary sciences and Agronomic sciences, Hadj Lakhdar University, Batna, Algeria 2 Institute of Veterinary sciences and Agronomic sciences, Hadj Lakhdar University, Batna, Algeria 3 Institute of Veterinary sciences and Agronomic sciences, Hadj Lakhdar University, Batna, Algeria 4 Institute of Veterinary sciences and Agronomic sciences, Hadj Lakhdar University, Batna, Algeria
EFFECT OF EXPOSURE TO CO2 LASER ON ANTIBIOTIC SENSITIVITY OF DIFFERENT BACTERIA ISOLATED FROM PATIENTS ATTENDING MOSUL GENERAL HOSPITAL, IRAQ

1. College of Environmental Sciences, University of Mosul, Iraq. 2. Department of Microbiology, College of Medicine, University of Mosul, Iraq. 3. Department of Microbiology, College of Science, University of Mosul, Iraq. Manuscript Info Abstract . Manuscript History:
COMPARISON OF THE EFFECTS OF INTRAVENOUS DEXMEDETOMIDINE WITH INTRAVENOUS MIDAZOLAM ON THE CHARACTERISTICS OF BUPIVACAINE SPINAL

Introduction: of late commencement of postoperative pain and reduced analgesic requirements. Midazolam has only sedative property. However, dexmedetomidine has both analgesic and sedative properties th prolong the duration of sensory and motor block obtained with spinal anesthesia. This study was designed to compare intravenous dexmedetomidine with midazolam and placebo on spinal block duration, analgesia and sedation. Method: spinal anesthesia at General Surgery 0T in Civil hospital Ahmedabad. Patients were randomly div into 3 groups D-received Dexmedetomidine 0.5 μg/kg i.v. M-received Midazolam 0.05 mg/kg i.v. S-received Normal Saline i.v. After 5 min all patients were induced under spinal anesthesia with 0.5%bupivacaine heavy 3 ml intrathecaly. Time taken for highe spinal block was noted. Duration of analgesia and sedation were recorded. Result: (p<0.001) or with S( T8. 154±9.89 min in D while 112±10.31 min in M (p<0.001) and 96.4±10.94 min in S (p<0.001). Duration of motor block was higher in D(194±9.94 min) compared to M(169±11.38 min) and S(169±18.3 Patients in D had 24 hrs mean VAS score <3 while patients in M and S needed rescue analgesic after 12 hr and 8 hr respectively as their VAS score were >3.The median of RAMSAY sedation score was 2(2-5) in D,3 (2 Conclusio bupivacaine induced spinal anesthesia with effective analgesia and sedation compared to intravenous midazolam.
FACTORS CONTRIBUTING TO MALNUTRITION AMONG CHILDREN UNDER FIVE YEARS OF AGE IN MACHAKOS COUNTRY LEVEL FIVE HOSPITAL

Background: Child malnutrition is one of the measures of health status that the World Health Organization (WHO) recommends for equity in health. According to WHO, 60% of all deaths occurring among children aged less than 5 years in developing countries is attributed to malnutrition. To improve on this condition, it is necessary to determine the determinants of malnutrition. Methods: This was a descriptive cross-sectional study conducted at Machakos Level five hospital from mothers attending MCH/FP clinic. Using random sampling, seventy (70) mothers and their children 6 months to 60 months participated in the study. Using a questionnaire, socio demographic characteristics and weaning practices were taken as well as children anthropometric measurements (mid-upper arm circumference – MUAC). SPSS version 16.0 statistical software was used for analysis. Results: Out of the seventy children who were involved in the study, 19 (27.1%) were males while 51 (72.9%) were females. The age ranged was 8 months to 60 months. The results obtained showed that socioeconomic factor, poor nutrition and mothers’ knowledge and feeding practices led to increase in the prevalence of malnutrition. Mid Upper Arm Circumference (MUAC) was measured using non-stretchable tape on left mid upper arm with the outcome showing that 17 (24.3%) had severe malnutrition, 8(11.4%) had moderate malnutrition, 31 (44.3%) had mild malnutrition while 14 (20%) were well nourished as classified according to World Health Organization. In addition, 41 (58.6%) of children were underweight and that only 22 (31.6%) practices exclusive breastfeeding for the first six months. There was a significant association between the age of the mother and child gender, weaning age of the child and baby feeding frequency per day (p˂0.05). Discussion: The findings from this study suggest that socio-economic factors such as lack of knowledge on the cause of malnutrition child feeding weaning age and the frequency of daily baby feeding practices are predictors of malnutrition in less than five. These findings are of practical importance because they can form part of preventing programs for community. Conclusion: Feeding practices (pre-lacteal feeding and complementary feeding practice) were related to malnutrition thus, nutritional intervention program in Machakos County in Kenya should focus on these factors in order to improve child feeding.
Antimicrobial Activity of Cymbopogon Citratus (Lemon Grass) and It’s Phytochemical Properties

The cold macerat ion and agar diffusion technique were employed to assess phytochemical propert ies and the antimicrobial potency of Cymbopogon citratus (lemongrass) against selected microbial pathogens using hexane, chloroform and methanol as extracting solvents. The mean zones of inhibit ion of the chloroform leaf and corresponding root extracts for the test organisms were Staphylococus aureus (11.33±1.15,11.66±2.52), Salmonella typhi (11.33±1.53,13.66±0.58), Escherichia co li (16.33±0.58,15.66±2.31) and Candida albicans (7.66±0.58,8.66±1.53) respectively. Hexane and methanol extracts showed no activity against the test organisms. The min imum inhib itory concentration (MIC) and the corresponding minimum bactericidal concentration (MBC) for ch loroform leaf and root extracts were : Staphylococus aureus (24μg/ml, 28μg/ml), Salmonella typhi (20μg/ml, 28μg/ml), Escherichia coli (14μg/ml, 16μg/ml), Candida albicans (32μg/ml, 38μg/ml) and Staphylococus aureus (20μg/ml, 26μg/ml), Salmonella typhi (18μg/ml, 24μg/ml), Escherichia coli (14μg/ml, 16μg/ml), Candida albicans (28μg/ml, 32μg/ml) respectively. Phytochemical screening on Cymbopogon citratus showed that five active ingredients: Tannins, Flavonoids, Phenols, Carbohydrates and volatile oil were present in both the root and leaf parts. The mean zones of inhibit ion showed that Cymbopogon citratus exh ibited an intermediate antimicrobial activity against the bacteria species while C. albicans was resistant. Higher dose of C. citratus may be recommended to exert a remarkable antimicrobial act ivity against the test organisms.
Prospective evaluation of yield of endoscopic ultrasonography in the etiological diagnosis of "idiopathic" acute pancreatitis

Abstract Background: Etiology of acute pancreatitis (AP) remains idiopathic in 30% of patients. Endoscopic ultrasound (EUS) has been shown to increase the diagnostic yield in patients with idiopathic AP (IAP). Aim: The aim of this study was to evaluate the role of EUS in achieving etiological diagnosis in patients with IAP. Materials and Methods: Consecutive 192 patients with IAP were evaluated prospectively with EUS over a period of 2 years. Patients who had no etiological diagnosis for AP after detailed history, clinical examination, laboratory investigations, and magnetic resonance cholangiopancreatography were included in the study. Results: The mean age of patients was 34.6 ± 12 and male:female ratio was 2.1:1. Of these, 135 patients had gallbladder intact (Group A) and 57 patients had undergone cholecystectomy (Group B). In Group A, EUS identified a possible cause in 79 (58.5%) patients; microlithiasis (n = 48), chronic pancreatitis (CP) (n = 23), common bile duct (CBD) and gallbladder stone (n = 3), pancreatic divisum (n = 3), small pancreatic tumor (n = 1), and anomalous pancreaticobiliary junction (n = 1). In Group B, EUS yielded diagnosis in 28 (49.1%) patients; CP (n = 22), ascariasis (n = 3), CBD stone (n = 2), and pancreatic divisum (n = 1). Overall EUS helped in achieving etiological diagnosis in 107 (55.1%) of patients with IAP. The presence of intact gallbladder showed a tendency for increased diagnostic yield (P = 0.06). Conclusion: EUS is a useful modality to establish the diagnosis in IAP and this technique should be incorporated in the evaluation of IAP.
GC-MS Analysis and antimicrobial activity of essential oil of Nepeta coerulescens

The chemical composition of the essential oil obtained from the leaves of Nepeta coerulescens collected from the Zanskar sub district of Kashmir, was analyzed by GC-MS. The major constituent terpene hydrocarbon was found out to be caryophyllene oxide (25.146%). The antimicrobial activity of essential oil of N.coerulescens was tested against five bacteria and two fungi, by disc diffusion method. Results showed that the oil exhibited mild antibacterial activity and good antifungal activity.
Candida Vulvo vaginitis in Pregnancy

Vulvovaginal candidiasis is common in pregnant women. Its signs and symptoms are redness, irritation, soreness and white vaginal discharge. In this study, 100 samples of high vaginal swabs and urine samples were collected from 100 pregnant women aged between (16 – 45) years suffering from signs and symptoms of vulvo vaginitis who visited the antinatal care unit of AL-Khansaa hospital. These swabs were examined under microscope, germ tube test, culture by sabourads dextrose agar and 10% KOH wet mount. All these tests were done to diagnose the Candida vulvo vaginitis. The result showed there is an increased prevalence of candida vulvo vaginitis (68%) in pregnant women. The prevalence increased in multi gravida (79%). The stage of pregnancy also affects prevalence, 50% of cases in third trimester of pregnancy. In diabetic women, there is a high prevalence. 88% of them have candida vulvo vaginitis. 55% of the cases have candidiasis in genital tract and urinary bladder.14% of cases have candida in urinary bladder but not candida in genital tract. History of recent usage of antibiotic has increased prevalence of candida vulvo vaginitis to 75% of cases. The age of pregnant women also affects the prevalence of candidiasis. Women aged 35 years, and less have 94% prevalence rate. Women more than 35 years old have only 5% prevalence rate. The importance of candida vulvo vaginitis comes from the complications which may occur in pregnant women who suffer from this infection like abortion, preterm labour, chorioaminonitis and transmissions of fungal infection to neonate So, with this high prevalence rate, examination of pregnant women must be done routinely to diagnose and treat the candida as early as possible.
Cerebrospinal fluid drainage using C-arm to prevent spinal cord injury in a patient with severe scoliosis undergoing thoracoabdominal aortic aneurysm repair

Postoperative paraplegia resulting from spinal cord ischemia is a devastating complication of thoracoabdominal aortic aneurysm repair. In that, various methods had been tried to prevent postoperative spinal cord ischemia. Crawford type I, II thoracoabdominal aneurysm has a high-risk of postoperative paraplegia and cerebrospinal fluid (CSF) drainage during surgery reduces this risk. Despite the benefits of CSF drainage, inserting CSF drainage catheter in patients with severe scoliosis has technical difficulties and may lead to major complications due to spinal deformity. For patients with severe scoliosis, the fluoroscopy and ultrasound image can be useful during CSF drainage catheter insertion. We report of a case of cerebrospinal fluid drainage using C-arm to prevent spinal cord injury in a patient with severe scoliosis undergoing thoracoabdominal aortic aneurysm repair. We have had a successful insertion of CSF drainage catheter without any technical difficulties and complications. The patient was discharged without any postoperative neurological symptoms.