Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring on-demand service use in large urban areas: the case of Rome

Traditional and innovative on-demand transport services, such as taxi, car sharing or dial-a-ride respectively, can provide a level of flexibility to the public transport with the aim to guarantee a better service and to reduce the exploitation costs. In this context, in order to point out the key-factors of on-demand services, this study focuses on traditional on-demand service (such as taxi one), and presents the results of a demand analysis and modelling, obtained processing taxi floating car data (FCD) available for the city of Rome. The GPS position of each taxi is logged every few seconds and it was possible to build a monthly database of historical GPS traces through around 27 thousands of GPS positions recorded per day (more than 750 thousands for the entire month). Further, the patterns of within-day and day-to-day service demand are investigated, considering the origin, the destination and other characteristics of the trips (e.g. travel time). The time-based requests for taxi service were obtained and used to analyse the trip distribution in space and on time. These analyses allow us to forecast trips generated/attracted by each zone within the cities according to land use characteristics and time slices. Therefore, a regression tree analysis was developed and different regressive model specifications with different set of attributes (e.g. number of subway stations, number of zonal employees, population) were tested in order to assess their contribution on describing such a service use.
Does a One-Size-Fits-All Minimum Wage Cause Financial Stress for Small Businesses?

Using intertemporal variation in the bounding of a state’s minimum wage by the federal rate and business credit-score data for 15.2 million establishments, we find that the increase in labor costs caused by a higher federal minimum wage leads to lower business credit scores and worsens the financial health of small businesses in the affected states. In particular, small, young, labor-intensive, and minimum-wage-sensitive establishments located in affected states and those located in competitive and low-income areas experience higher financial stress. Increases in the minimum wage are associated with employment reductions and a higher exit rate for small businesses. Our results document some potential costs of a one-size-fits-all nationwide minimum wage for some small businesses. This paper was accepted by Gustavo Manso, finance. Funding: This work was supported by the Ewing Marion Kauffman Foundation Junior Faculty Fellowship. Supplemental Material: The data and internet appendix are available at https://doi.org/10.1287/mnsc.2022. 4620 .
Combining Ability of Quality Protein Maize Inbred Lines for Yield and Morpho-Agronomic Traits under Optimum as Well as Combined Drought and Heat-Stressed Conditions

Drought and heat stress have perceptibly become major maize (Zea mays L.) yield reducing factors in Sub-Saharan Africa. As such, the objectives of this study were to: (i) determine the type of gene action conditioning tolerance to combined drought and heat stress (CDHS), and (ii) identify inbred lines with good combining ability for yield and other morpho-agronomic traits under CDHS. Twenty-four single cross hybrids (SCHs) obtained from crossing 10 inbred lines in a 4 × 6 North Carolina Design II, and a drought-tolerant check, were evaluated under CDHS and optimum conditions in the field. The experiment was laid out in a 5 × 5 alpha lattice incomplete block design, replicated three times. Additive gene effects influenced all the traits under CDHS except grain yield, which was influenced by non-additive gene effects. A preponderance of additive genetic effects was observed for all traits recorded under optimum conditions. Inbred lines L30, L6, L5, L17 and L2 showed good combining ability for yield under CDHS, indicating that they could be good parental lines in hybridization programs. Based on the results, SCHs L2*30, L6*13 and L5*18 exhibited high specific combining ability (SCA) effects for yield under CDHS. These hybrids are recommended for further multi-locational evaluation to determine the stability of their performance.
Dissecting chronic myeloid leukaemia overlapping transcriptome with TIF-Seq2

Eukaryotic transcriptomes are complex involving thousands of overlapping transcripts. The interleaved nature of the transcriptome limits our ability to identify regulatory regions and, in some cases, can lead to misinterpretation of gene expression. To improve the understanding of the overlapping transcriptome, we have developed an optimized method, TIF-Seq2, able to sequence simultaneously the 5’ and 3’ ends of individual RNA molecules at single-nucleotide resolution. We investigated the transcriptome of a well characterized human cell line (K562) and identify thousands of unannotated transcript isoforms. By focusing on transcripts which are challenging to be investigated with RNA-seq, we accurately defined boundaries of lowly expressed unannotated and read-though transcripts putatively encoding fusion genes. We validated our results by targeted long-read sequencing and standard RNA-Seq for chronic myeloid leukaemia patient samples. Taking the advantage of TIF-Seq2, we explore transcription regulation among the overlapping units and investigate their crosstalk. We show that most overlapping upstream transcripts use poly(A) sites within the first 2 kb of the downstream transcription unit. Our work shows that, by paring the 5’ and 3’ end of each RNA, TIF-Seq2 can improve the annotation of complex genomes, facilitates accurate assignment of promoters to genes and easily identify transcriptionally fused genes. Key points Study of TSS-PAS co-occurrence allows dissecting complex overlapping transcription units. Partially overlapping transcription units in human commonly use PAS within the first 2Kb. TIF-Seq2 facilitates the identification of lowly expressed and transcriptionally fused genes.
Awareness and attitude towards obturation techniques and materials used by students in dental colleges of tamil nadu

AimThe main aim of the study is to survey about the type of obturation technique that is most commonly followed by the students in dental colleges of Tamil Nadu. ObjectiveTo Investigate the endodontic profile of students and understand the most common obturation technique that is followed among students and the reason behind them following that particular technique. BackgroundThe attitudes, techniques and different appro endodontic treatment reflects the quality of the root canal treatment performed by students in the dental colleges.The long term success of endodontic therapy depends not only on preoperative status of the pulp and periapical tissues but also on a number of procedure related factors. ReasonTo understand the attitude of various students in dental colleges towards various obturation techniques.
Scanning electron microscopy preparation and analysis of the cell cortex ultrastructure

The cellular cortex is a 200-nm-thick actin network that lies beneath the cell membrane. It is responsible for the mechanical properties of the cell and is involved in many cellular processes, such as cell migration and interactions with the environment. To develop a clear view of the structure of this meshwork, high resolution imaging is essential, such as electron microscopy. This technique requires complex sample preparation that can lead to artifacts like shrinkage or hole formation. We present a preparation method that reduces artifacts significantly. Here, the final drying step that is typically performed by critical point drying is replaced by hexamethyldisilazane drying. We quantitatively investigated sample integrity after both preparation methods, and show that there are significant advantages of hexamethyldisilazane drying compared to critical point drying. Furthermore, automated analysis of a network is classically performed by thresholding-based software programs, which are sensitive to noise and uneven brightness of images. The here presented analysis that we have developed is based on a vectorial node algorithm. It reproduces all kinds of networks sufficiently to allow derivation of quantitative network-specific parameters, such as mesh hole size. We use this analysis to compare the network structure of cells prepared by these two drying methods, and show that hexamethyldisilazane drying leads to fewer artificial mesh holes compared to critical point drying. We thus present here a significantly improved method to quantitatively investigate the actin cortex of cells, and show that hexamethyldisilazane drying leads to more accurate imaging compared to critical point drying.
First Oral Short-course Treatment for Adults with Highly Active Relapsing Multiple Sclerosis Now Approved in Europe

Disclosure: Gavin Giovannoni has received compensation for serving as a consultant or speaker for, or has received research support from: AbbVie, Almirall, Atara Bio, Bayer Schering Healthcare, Biogen Idec, Canbex, Eisai, Elan, Fiveprime Therapeutics, Genzyme, Genentech, GlaxoSmithKline, Ironwood Pharmaceuticals, Merck-Serono, Novartis, Pfizer, Roche, Sanofi-Aventis, Synthon BV, Teva Pharmaceutical Industries, UCB and Vertex Pharmaceuticals. This is an expert interview and as such, has not undergone the journal’s standard peer review process.
Do you see my pain? Aspects of pain assessment in hospitalized preverbal children

iii List of scientific papers . iv List of abbreviations . viii Foreword . 1 1 Introduction . 2 2 Background . 3 2.1 What is pain? 3 2.1. 1 Both an individual experience and a social construction . 3 2.2 Theoretical framework . 3 2.2.1 The Social Communication Model of Pain . 3 2.2.2 Overview of the model . 4 2.2.3 How the model has been used in this thesis . 5 2.3 The preverbal child . 5 2.3.1 Pain exposure in hospitalized preverbal children . 5 2.3.2 Experience of pain . 6 2.3. 3 Expression of pain . 6 2.3. 4 Factors influencing the experience and expression of pain . 7 2.4 The nurse assessor . 8 2.4.1 Pain assessment . 8 2.4.2 Pain management . 9 2.4. 3 Factors influencing the assessment and management of pain . 10 2.5 Pain measurement . 11 2.5. 1 Observational pain measurement scales . 11 2.5. 2 The COMFORT behavioral scale . 11 2.5. 3 Use of pain scales in clinical practice . 12 2.5. 4 Alternatives to the use of observational pain scales . 13 2.6 Measurement properties of pain scales . 13 2.6. 1 Why measurement properties matter . 13 2.6. 2 Taxonomy . 13 2.6. 3 Reliability . 14 2.6. 4 Validity . 15 2.6. 5 Responsiveness . 15 2.6. 6 Interpretability . 16 2.6. 7 Scale validity . 16 2.7 Rationale for the thesis . 17 3 General and specific aims . 18 3.1 General aim . 18 3.2 Specific aims . 18 4 Material and methods . 19 4.1 General overview . 19 4.2 Study I . 20
Children’s Food Environment : Studies on environmental determinants of primary school children’s dietary behaviour

markdownabstract__Abstract__ Dietary behaviour is related to overweight and obesity, but also to several chronic diseases such as diabetes mellitus type II. Some dietary behaviour may reduce the risk of obesity or chronic diseases (‘healthy’ dietary behaviour), while other dietary behaviour may increase the risk of developing obesity or chronic diseases (‘unhealthy’ dietary behaviour). Given the high and increasing prevalence rates of overweight and obesity in the last decades, the adverse health consequences and, given the fact that childhood obesity tracks into adulthood, prevention of overweight and obesity among children is an important public health issue. However, to improve the dietary behaviour of children more insight is needed into the determinants of dietary behaviour among children. This thesis investigate the influence of determinants of the home, school and neighbourhood environment. As obesity and poor dietary intake are more common among children from parents with a low educational background, this thesis also investigates whether environmental determinants can explain socio-economic inequalities in children’s dietary behaviour. The specific aims of this thesis are: - To investigate modifiable environmental determinants of dietary behaviour of primary school children aged 10-12 years. - To investigate socio-economic inequalities in dietary behaviour of primary school children aged 10-12 years. - To investigate whether modifiable environmental factors can explain socio-economic inequalities among primary school children aged 10-12 years. Results from the first part of this thesis show that factors related to the home food environment are associated with the dietary behaviour of 10-12 year old primary school children’s and are, therefore, important targets for health interventions. Regarding the school food environment, it was concluded that the school food policy can be an important tool to foster healthy dietary behaviour among children. The second part of this thesis shows that children from a lower socio-economic background have the least favourable dietary behaviour. In addition, the results that home environmental factors can explain socio-economic inequalities in children’s dietary behaviour.
Inpatient Utilization of Computed Tomography: the Influence of Market, Hospital, and Patient Characteristics

INPATIENT UTILIZATION OF COMPUTED TOMOGRAPHY: THE INFLUENCE OF MARKET, HOSPITAL, AND PATIENT CHARACTERISTICS By Michael D. Hanshew, Ph.D., M.S. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Health Related Sciences—Health Administration at Virginia Commonwealth University. Virginia Commonwealth University, 2017 Major Director: Carolyn Watts, Ph.D., Department of Health Administration The use of computed tomography (CT) in the care of patients has grown dramatically since its introduction over 30 years ago. The vast majority of the utilization research has focused on factors associated with the variable use in the outpatient and emergency department settings. This has left much of the inpatient use and variation understudied. This study has multiple aims. The first is to characterize the inpatient variation across multiple states and markets. The second is to evaluate the relationship between inpatient CT use and commercial payers across these areas. The third is to develop a model to evaluate the relationship between inpatient CT use and the characteristics of markets, hospitals, and patients. The study uses a four-state convenience sample of cross-sectional data for hospitals. It included non-Federal, acute care hospitals that reported the performance of inpatient CT exams during 2015 (N=181). The literature review was used to justify the inclusion of variables in the study. The descriptive analyses were used to justify the appropriateness of the variables and methodology for testing. A comparison of means demonstrated the significant differences for inpatient utilization between states. A univariate general linear model demonstrated a negative relationship with a hospital’s proportion of commercially insured patients and the inpatient utilization rate. An ordinary least squares multivariate linear regression was used to test for variable significance within each of three constructs: markets, hospitals, and patients. The results indicated that inpatient CT rates were positively associated with higher level of insurer concentration (market), positively associated with system centralization (hospitals), and negatively associated with a hospital’s increasing proportion of minority patient discharges (patients). The study serves an important function in identifying varying patterns of CT utilization across the full spectrum of inpatients across multiple states, regardless of payer. It also creates new knowledge about how the characteristics of these markets, hospitals, and patients are related to inpatient use. It also provides implications for administrators, researchers, and policy makers. The additional knowledge and understanding provided by this research have the potential to lead to improvements in the appropriate and equitable use of inpatient CT exams.
The Prevalence of High-Normal Blood Pressure and Hypertension among 8 to 15-Year-Old Bulgarian Children and Adolescents with Various Nutritional Status (Smolyan Region, 2012-2014)

Abstract The aim of this paper is to investigate the prevalence of high-normal blood pressure and hypertension among 8 to 15-year-old Bulgarian children and adolescents with various nutritional status in the region of Smolyan, Bulgaria. The sample population of the study was 873 children between the ages of 8 to 15 years, examined by a cross-sectional study in the period 2012-2014. For each child was measured weight, height, waist circumference, blood pressure as well as body mass index and waist to height ratio. The results show that the high-normal blood pressure is found in average 20.3 percent of children and adolescents, while hypertension is found in 3.4 percent. The percentage of children with high-normal blood pressure and central obesity is 35.4 percent, and with hypertension and central obesity is 7.1 percent. Positive significant correlations between BMI, WHtR and blood pressure are observed in both sexes. The prevalence of children with high-normal blood pressure and hypertension and with central obesity increases.
Seram, the Seram Trough, the Aru Trough, the Tanimbar Trough and the Weber Deep: A new look at major structures in the eastern Banda Arc

Multibeam bathymetry data, combined with 2D seismic data and studies on land, provide new insights into the major structures in the northern and eastern Banda Arc. In the west, north of Buru, is the deep Buru basin where there is evidence of extension with probable Neogene oceanic crust. To the east, the thrust front of the Seram fold and thrust belt (FTB) can be traced along the Seram trough which turns from E-W to N-S to pass through the Kai Islands into the Tanimbar trough. The thrust front is not east of the Kai Islands as often drawn. Between the Kai and Aru Islands is the Aru trough bounded by NNESSW-trending normal faults which converge to the SW and can be traced southwards into the Tanimbar trough. An important WNW-ESE-trending, probably inactive, fault bounds the northern end of the Aru trough south of the Bird’s Head that we name the Kumawa fault. It is partly buried below disturbed sediments that have slumped from the shelf south of the Lengguru FTB. This is a major tectonic feature. To the north there is a late Neogene history of contraction that formed the Misool–Onin–Kumawa Ridge and Lengguru FTB. To the south, east of the thrust front, extensional structures dominate. We propose that the Kumawa fault links to the Kawa shear zone of Seram which together form a lithosphere-scale sinistral shear zone active during the Miocene and Pliocene which exhumed deep crust and mantle on Seram. The Kumawa fault offsets the Seram thrust front close to the Kumawa peninsula. To the east is the E-W-trending Tarera–Aiduna fault zone that can be traced offshore only a short distance from the Bird’s Head. This is a very young structure with little displacement which does not reach the Seram Trough. However, present-day seismicity indicates active E-W extension of the Aru trough and strike-slip movement on the Tarera–Aiduna fault zone. The Seram trough began to form in the Late Pliocene due to loading by the Seram FTB. The Tanimbar trough originated in the Late Miocene as an elongate extensional structure within the Australian continental margin. Neither troughs are subduction zones. Almost all active deformation in the Seram FTB is on Seram, and offshore south of the trough and north of the Kumawa fault. There is almost no seismicity at the trough itself, unlike modern subduction zones. South of the Kumawa fault is a wide FTB, trending roughly N-S towards the Kai Islands and Tanimbar, with young mud volcanism but little seismicity. Immediately west of the FTB is the Weber deep, the Earth’s deepest forearc basin, which is a young extensional basin bounded by a major low angle detachment on its eastern side. It is the most recent manifestation of eastward Banda subduction rollback, and may still be active.
INTRINSIC CONTROL OF ACTIVITY OF STRIATED MUSCLE BY LENGTH CHANGES

The mechanical effect of length changes on active muscles has been studied under various conditions. The results have been essentially the same in cardiac, skeletal and insect ﬂight muscles. The simplest results have been obtained during sustained states of contraction, such as contractures in depolarized muscles. Shortening increases tension; stretching has a relaxing action. Because these responses, as shown most directly in insect ﬂight muscles, are not caused by changes in free Ca and are, therefore, induced by a mechanism different from activation, the terms ‘augmentation’ respectively ‘deaugmentation’ were introduced for these responses. These processes have also been demonstrated during twitches of cardiac and skeletal muscle, where they act as positive feedback. They explain important features of the isotonic twitches, and some important differences between cardiac and skeletal muscles. These results agree closely with our knowledge of the energetics of muscle. The responses evidently are designed to increase energy release during shortening and to speed up relaxation, thereby increasing the output of mechanical power.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF PADA MATA PELAJARAN SISTEM KOMPUTER DI SMK

The use of computer-based instructional media at Vocational High School (SMKN) 3 Pariaman is still limited to a media presentation using power point. Along with the advancement of information and communication technology (ICT), a lot of software that can be used to create interactive learning media. The results of the preliminary survey of the implementation of learning system computer at SMKN 3 Pariaman shows that there are no teachers who use interactive learning media with Adobe Director software. ICT facilities and infrastructure such as computers, LCD projectors, and internet at SMKN 3 Pariaman existing one, but have not used optimally. Learning media is one important factor in improving student learning outcomes. The selection of learning media in accordance with the needs and characteristics of students can help students understand the subject matter. This research aims to produce an interactive learning media that valid, practical, and effective to help students to master the subject of System Computer.The research method used was R&D (research and development) by using 4D development model (define, design, develop and disseminate). The results showed that interactive learning media is valid based on the assessment of each aspect by the validator. interactive learning media is considered practical based on observation and responses teacher and student. This shows that, Interactive Learning Media otherwise effective use as a medium of learning in improving student learning outcomes. Keywords: I nteractive Learning Media, Sistem Komputer, Adobe Director