Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating concentrations of thyroid hormones and cortisol in wild and semi-natural Yangtze finless porpoise (Neophocaena asiaeorientalis).

Our understanding about how environmental and biological variables may influence circulating thyroid and adrenal hormones in free-ranging cetaceans is limited. As such, we used liquid chromatography-mass spectrometry to determine concentrations of circulating cortisol and thyroid hormones (THs; tT3, tT4) in 132 Yangtze finless porpoises (YFPs) located in Poyang Lake, (PL, n = 92) and Tian-E-Zhou Oxbow reserve (TZO, n = 40). For overall hormone comparisons, animals were partitioned by age [juvenile and adult (male and non-pregnant, non-lactating female)], sex, season (winter or spring) and geographical location. Geographically, during winter, circulating THs were significantly higher in the PL versus TZO population. Seasonally, within PL, THs were significantly higher in the winter versus spring season. Animals were further binned into groups as follows: juvenile male (JM) and juvenile female (JF), adult male (AM), non-pregnant adult female, pregnant female and non-pregnant lactating female. Intra-group comparisons between locations showed a significant increase in JM THs at PL. Significant increases in THs during winter compared to spring were detected between JM and JF groups. Mean comparisons of cortisol within and between locations for each group identified a significant increase for TZO AM versus TZO pregnant female and JM and JF. Seasonally, in PL, only JF has significantly higher cortisol in winter versus spring. Finally, we established reference values of THs and cortisol for YFPs in different geographical locations. These references are important baselines from which the effects of environmental and biological variables on THs and cortisol may be evaluated.
Advances in Aza‐Claisen‐Rearrangement‐Induced Ring‐Expansion Strategies

The aza-Claisen rearrangement, also known as the 3-aza-Cope rearrangement, has attracted significant attention because it can be used as a complimentary method to access a diverse range of useful organic molecules. The presence of a nitrogen atom at the 3-position enables the tethering of various-sized azacycles, thereby giving ring-expansion strategies that take advantage of the aza-Claisen rearrangement a distinct advantage compared to other [3,3]-sigmatropic rearrangements. Recent advances in aza-Claisen rearrangements have facilitated otherwise-inaccessible ring expansions in a highly stereoselective manner. The utility of aza-Claisen-rearrangement-induced ring-expansion strategies has been exemplified in the synthesis of a diverse range of natural products. This Focus Review summarizes recent advances in aza-Claisen-rearrangement-induced ring-expansion strategy, in particular applications in the synthesis of bioactive alkaloids.
The Acceptance Technology Model for Adoption of Social Media Marketing in Jabodetabek

The research aimed to provide information about the influence and impacts of social media marketing (SMM) in promoting micro, small, and medium enterprises (MSMEs) in Indonesia. The approach of the research was quantitative research with data collection method using the electronic questionnaires of Google forms obtaining 163 respondents who were owners of MSMEs in Jakarta and Tangerang. The measurement model of outer and inner model was analyzed by SmartPLS software. Structural Equation Model was being used to test the relations of each construct. The findings show that SMM positively mediates: 1) the relationship between perceived usefulness and impact on business, 2) the relationship between perceived ease of use and impact on business, 3) the relationship between compatibility and impact on business, and 4) the relationship between cost and impact on business, which conclude that SMM has positive impacts on business. On the other hand, SMM negatively mediates the relationship between facilitating conditions and impact on business. The research implies that the adoption of social media marketing by MSMEs is encouraged by such factors as usefulness, ease of use, compatibility, and cost. Hence it is advisable that MSMEs facilitate the employees with technical infrastructures and training to increase productivity and performance.
Characterization of voltage-sensing phosphatase regulation on membrane phosphoinositides and voltage-gated calcium channels

이 논문은 비교적 최근 발견된 전압감응 탈인산화효소(voltage-sensing phosphatase, VSP)가 세포막 인지질의 일종인 이노시톨인지질을 탈인산화 하는 생물물리학적 특징에 관한 내용을 다루고 있다. VSP는 종양억제 효소로 알려진 PTEN의 상동체이다. PTEN이 PI(3,4)P2와 PI(3,4,5)P3의 3번 인산기를 탈인산화 시키는 것과는 달리 VSP는 PI(3,4)P2, PI(4,5)P2 및 PI(3,4,5)P3의 3번과 5번 인산기를 탈인산화 하는 것으로 알려져 있으나PIP3의 3번 인산기에 대한 탈인산화 작용에 대해서는 이견이 있었다. 또한, 최근 연구에서는 VSP가 여러 기질에 대해 각각 다른 전압의존성을 가지고 있다는 결과를 발표했다. 본 연구에서 우리는 여러 종류의 이노시톨인지질에 대한 Forster Resonance Energy Transfer(FRET) 표지를 이용해 살아있는 세포에서 전압 변화에 따른 각각의 기질에 대한 VSP의 3번과 5번 포스파타아제 작용의 특성을 측정했다. 먼저, PI 4 monophosphate 5-kinase type Iγ (PIPKIγ)가 VSP의 5번 포스파타아제 작용에 대해 선택적으로 길항작용을 한다는 것을 발견했고, 이 현상을 이용해 VSP가 PI(3,4,5)P3의 3번 인산기를 탈인산화 시켜 PI(4,5)P2를 생성함을 실험적으로 증명했다. 또한, VSP의 작용으로 알려진 PI(3,4,5)P3→PI(4,5)P2, PI(3,4,5)P3→PI(3,4)P2, PI(4,5)P2→PI(4)P, PI(3,4)P2→PI(4)P 반응들에 대한 전압의존성을 정량화하고 모델링 하는 데에 성공했다. 이 반응들은 VSP의 기질선호도와 이노시톨 인지질들의 내생적인 농도로 인하여 각각 다른 막전위에서 반응이 시작되는 것처럼 보였으나, 명백하게 하나의 전압의존성을 가지고 있는 것으로 판명됐다. 우리가 수립한 모델에 의하면 zebrafish VSP에서 PI(4,5)P2의 5번 인산기에 대한 탈인산화 효과가 PI(3,4,5)P3의 3번 인산기에 대한 탈인산화 효과에 비해 55배 크기 때문에 VSP에 의해 PI(3,4,5)P3의 3번 인산기가 탈인산화 되어 PI(4,5)P2가 생성되더라도 PI(4)P로 바로 바뀌기 때문에 지금까지 살아있는 세포에서 VSP의 PI(3,4,5)P3에 대한 3번 인산기의 탈인산화를 관찰하지 못한 것으로 드러났다. 또한 이러한 VSP의 특성을 실험적으로 응용하여q타입의 G 단백질 연결 수용체 (GqPCR)이 이노시톨인지질 중 하나인 PI(4,5)P2의 고갈과 G단백질 연결 수용체의 βγ 아단위체의 직접적인 부착의 두 가지 경로를 통하여 전압감응 칼슘채널 (CaV channel)의 활성화를 억제하는 것과 이러한 양 갈래 억제의 비율이 CaV채널의 β아단위체의 세포 내 위치에 의해 조절됨을 보여주었다. ⓒ 2016 DGIST
Charters Without Lotteries: Testing Takeovers in New Orleans and Boston

Lottery estimates suggest oversubscribed urban charter schools boost student achievement markedly. But these estimates needn't capture treatment effects for students who haven't applied to charter schools or for students attending charters for which demand is weak. This paper reports estimates of the effects of charter school attendance on middle-schoolers in charter takeovers in New Orleans and Boston. Takeovers are traditional public schools that close and then re-open as charter schools. Students enrolled in schools designated for closure are eligible for "grandfathering" into the new schools; that is, they are guaranteed seats. We use this fact to construct instrumental variables estimates of the effects of passive charter attendance: the grandfathering instrument compares students at schools designated for takeover with students who appear similar at baseline and who were attending similar schools not yet closed, while adjusting for possible violations of the exclusion restriction in such comparisons. Estimates for a large sample of takeover schools in the New Orleans Recovery School District show substantial gains from takeover enrollment. In Boston, where we can compare grandfathering and lottery estimates for a middle school, grandfathered students see achievement gains at least as large as the gains for students assigned seats in lotteries. A non-charter Boston turnaround intervention that had much in common with the charter treatment generates gains as large as those seen for takeovers, but other more modest turnaround interventions produce much smaller effects.
Quality Attributes of Curcuma longa in response to Populus deltoides Tree Spacings and Nutrient Sources

Turmeric (Curcuma longa L.) also called as “Indian saffron” is an ancient, most valuable and sacred spice crop of India where large amount of Turmeric is produced, consumed and exported. It belongs to family Zingiberaceae and is native to the Indian subcontinent and southeast Asia and grows well in temperature between 20 0 -30 0 C (Anonymous, 2017). It is mainly propagated through rhizome with a seed rate of 20-25 q/ha sown during the month of April-May in midhill regions of the country (Anonymous, 2014). Indian Turmeric is considered best in the world market because of its high curcumin content i.e. 3.14 % by weight (Hembram, 2014). Curcumin the yellow colour bioactive pigment present in the rhizome was identified in 1815 which has antioxidant, antiinflammatory, anticancer, antibacterial, antirheumatic, antidiabetic and antiviral International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 10 Number 02 (2021) Journal homepage: http://www.ijcmas. com
Integrating the Concept of Plane Figure and Baduy Local Wisdom as a Media Alternative of Mathematics Learning In Elementary Schools

This study aims to develop a learning media product that contains the local wisdom of the Baduy tribe. The method used in this research is an ethnographic study to collect data about the Baduy tribe buildings that contain geometric elements. After the data was collected, the researcher used the instructional design research method in the form of the ADDIE model with the aim of making learning media by integrating the local wisdom of the Baduy Tribe in learning geometry based on previous ethnographic studies. The subjects in this study were the Baduy people, teachers, and grade 4 students of one of the elementary schools in Serang City. The results of this study indicate that learning geometry by integrating the local wisdom of the Baduy tribe is very effective in the learning process, so that the learning media product in the form of geomatics cards that are made is ready to be used and implemented in the concept of the plane figure in elementary schools. This research is expected to contribute to education, especially in creating effective learning by integrating culture in mathematics learning in elementary schools.Penelitian ini bertujuan untuk mengembangkan sebuah produk media pembelajaran yang memuat kearifan lokal suku Baduy. Metode yang digunakan dalam penelitian ini adalah studi etnografi untuk mengumpulkan data-data tentang bangunan suku Baduy yang memuat unsur geometri. Setelah data terkumpul, peneliti menggunakan metode instructional design research berupa model ADDIE dengan tujuan untuk membuat media pembelajaran dengan mengintegrasikan kearifan local Suku Baduy pada pembelajaran geometri berdasarkan kajian etnografi sebelumnya. Subjek dalam penelitian ini adalah masyarakat Suku Baduy, guru dan siswa kelas 4 salah satu sekolah dasar di Kota Serang. Hasil penelitian ini menunjukkan bahwa pembelajaran geometri dengan mengintegrasikan kearifan local Suku Baduy sangat efektif diterapkan dalam proses pembelajaran, sehingga produk media pembelajaran berupa kartu geomatika yang dibuat telah siap digunakan dan diimplementasikan padaÂ konsep bangun datar di sekolah dasar. Penelitian ini diharapkan dapat memberikan kontribusi dalam dunia pendidikan khususnya dalam menciptakan pembelajaran yang efektif dengan mengintegrasikan budaya pada pembelajaran matematika di sekolah dasar.
Nonresonant explanation for the Y ( 4260 ) structure observed in the e + e − → J / ψ π + π − process

In this work, we propose a nonresonant explanation for the $Y(4260)$ structure observed in the ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}J/\ensuremath{\psi}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ process, i.e., $Y(4260)$ is not a genuine resonance. Our result indicates that the $Y(4260)$ structure can be reproduced by the interference of production amplitudes of the ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}J/\ensuremath{\psi}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ processes via direct ${e}^{+}{e}^{\ensuremath{-}}$ annihilation and through intermediate charmonia $\ensuremath{\psi}(4160)/\ensuremath{\psi}(4415)$. Besides describing the $Y(4260)$ line shape in ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}J/\ensuremath{\psi}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ well, such a nonresonant explanation for the $Y(4260)$ structure naturally answers why there is no evidence of $Y(4260)$ in the exclusive open-charm decay channel and $R$-value scan.
The Effect of E-Learning on Students' Learning Interest in the Equivalence Education Program

The Equivalence Education Program is non-formal education that applies learning with the e-learning system to substitute conventional learning in formal education school. This study aims to identify and analyze (1) e-learning conducted by students, (2) students 'interest in learning, and (3) the effect of e-learning on students' learning interest in the Package C Equivalence Program at PKBM Pioneer Karanganyar. The method used is a quantitative approach focusing on the ex post facto approach. The research sample was 45 students of Package C at PKBM Pioneer Karanganyar, out of a total population of 141 Package C students. The data were collected using questionnaire and documentation. The analysis technique used is statistical and inferential analysis techniques focusing on simple linear regression analysis techniques. The results showed that (1) Package C students at PKBM Pioneer Karanganyar appreciated that the e-learning was equivalent to online learning (2) Package C students at PKBM Pioneer Karanganyar had high learning interest, (3) there was a positive influence and e-learning was significant for students' interest in learning in the Package C Program at PKBM Pioneer Karanganyar. The benefit of this research is to provide an overview of online learning that is fun to students.
Stellar Dynamics and Stellar Phenomena Near a Massive Black Hole

Most galactic nuclei harbor a massive black hole (MBH), whose birth and evolution are closely linked to those of its host galaxy. The unique conditions near the MBH—high velocity and density in the steep potential of a massive singular relativistic object—lead to unusual modes of stellar birth, evolution, dynamics, and death. A complex network of dynamical mechanisms, operating on multiple timescales, deflects stars to orbits that intercept the MBH. Such close encounters lead to energetic interactions with observable signatures and consequences for the evolution of the MBH and its stellar environment. Galactic nuclei are astrophysical laboratories that test and challenge our understanding of MBH formation, strong gravity, stellar dynamics, and stellar physics. I review from a theoretical perspective the wide range of stellar phenomena that occur near MBHs, focusing on the role of stellar dynamics near an isolated MBH in a relaxed stellar cusp.
MyWear: A Novel Smart Garment for Automatic Continuous Vital Monitoring

Wearables are getting large acceptance in the continuous monitoring of health status and physiological data. Medical devices and their connectivity through Internet along with the electronics health record (EHR) and AI analytics making smart healthcare possible. Internet-of-Medical-Things (IoMT)-end devices like wearables and implantables are key for smart healthcare. Smart garment is a specific wearable which can be used for smart healthcare. This paper presents the design and development of a smart garment called MyWear that continuously monitors and collects physiological data. It can analyze muscle activity, stress levels, and heart rate variations and send all the data to the cloud. Through abnormal variations in vitals, it can also predict the risk of heart failure and with the in-built alert system, it can notify the associated medical officials if necessary. We also propose a deep neural network model that classifies heartbeat data into abnormalities with 96.9% accuracy and 97.3% precision.
COVID-19, Loneliness and Technological Addiction: Longitudinal Data

The COVID-19 outbreak has been shown to have had a negative impact on mental health: furthermore, lockdown measures may have increased levels of loneliness and addiction. Preliminary studies indicated an increased frequency of gaming and social media use during this time and augmented levels of loneliness likely account for the increase in gaming and social media addiction during lockdown. We conducted a longitudinal study administering a battery of self-report questionnaires at the beginning of lockdown (Stage 1) and three days before the end of the lockdown (Stage 2). Specifically, we measured loneliness feelings, frequency of gaming, and social media use, as well as both gaming and social media addiction. Data were analysed using Structural Equation Modeling. We found that loneliness levels longitudinally predicted both gaming and social media addiction, even when controlling for gaming and social media use at Stage 1. Increased feelings of loneliness, a well-known risk factor for gaming, along with social media addiction, may be a central variable heightening vulnerability to the onset or the maintenance of technological addiction during forced social isolation. Thus, future preventive interventions may want to target this issue. RésuméL’éclosion de la COVID-19 a eu un effet nuisible sur la santé mentale. De plus, les mesures de confinement ont intensifié la solitude et les addictions. Les études préliminaires indiquent une augmentation de la fréquence d’utilisation des jeux vidéo et des médias sociaux pendant cette période. Cette hausse est probablement attribuable à l’accroissement de la solitude. Nous avons mené une étude longitudinale à l’aide d’une batterie de questionnaires d’autoévaluation, qui ont été remplis au début du confinement (étape 1) et trois jours avant la fin du confinement (étape 2). En particulier, nous avons mesuré le sentiment de solitude, la fréquence d’utilisation des jeux vidéo et des médias sociaux, et la dépendance aux jeux vidéo et aux médias sociaux. Nous avons eu recours à la modélisation par équation structurelle pour analyser les données. Nous avons observé que le niveau de solitude est un prédicteur longitudinal de la dépendance aux jeux vidéo et aux médias sociaux, en contrôlant par l’effet de l’utilisation des jeux vidéo et des médias sociaux observée à l’étape 1. Le sentiment accru de solitude, qui est un facteur de risque connu de dépendance aux jeux vidéo et aux médias sociaux, pourrait être une variable centrale de l’accroissement de la vulnérabilité au développement ou à la persistance d’une dépendance à la technologie dans un contexte d’isolement social imposé. Par conséquent, les interventions à venir en matière de prévention pourraient cibler ce problème.
Development and validation of an online emotional intelligence training program

Introduction Emotional intelligence (EI) is associated with a range of positive health, wellbeing, and behavioral outcomes. The present article describes the development and validation of an online training program for increasing EI abilities in adults. The training program was based on theoretical models of emotional functioning and empirical literature on successful approaches for training socioemotional skills and resilience. Methods After an initial design, programming, and refinement process, the completed online program was tested for efficacy in a sample of 326 participants (72% female) from the general population. Participants were randomly assigned to complete either the EI training program (n = 168) or a matched placebo control training program (n = 158). Each program involved 10-12 hours of engaging online content and was completed during either a 1-week (n = 175) or 3-week (n = 151) period. Results Participants who completed the EI training program showed increased scores from pre- to post-training on standard self-report (i.e., trait) measures of EI (relative to placebo), indicating self-perceived improvements in recognizing emotions, understanding emotions, and managing the emotions of others. Moreover, those in the EI training also showed increased scores in standard performance-based (i.e., ability) EI measures, demonstrating an increased ability to strategically use and manage emotions relative to placebo. Improvements to performance measures also remained significantly higher than baseline when measured six months after completing the training. The training was also well-received and described as helpful and engaging. Discussion Following a rigorous iterative development process, we created a comprehensive and empirically based online training program that is well-received and engaging. The program reliably improves both trait and ability EI outcomes and gains are sustained up to six months post-training. This program could provide an easy and scalable method for building emotional intelligence in a variety of settings.
Spatial prediction of shallow landslide: application of novel rotational forest-based reduced error pruning tree

Abstract Landslides are a form of soil erosion threatening the sustainability of some areas of the world. There is, therefore, a need to investigate landslide rates and behaviour. In this research, we introduced a novel hybrid artificial intelligence approach of rotation forest (RF) as a meta classifier based on reduced error pruning tree (REPTree) as a base classifier called RF-REPTree, for landslide susceptibility mapping (LSM) in the Kalaleh watershed, Golestan Province, Iran. Some benchmark models, including the open-source Java decision tree (J48), naive Bayes tree (NBTree), and REPTree were used to compare the designed model. A total of 249 landslide locations were identified and mapped. The group was split into training (70%) and testing (30%) data for modelling and reliability analysis. Based on a literature review and multi-collinearity tests, 16 landslide conditioning factors (LCFs) were selected. Of the LCFs, the topographical position index (TPI) had the highest correlation with landslide occurrence. The LSM produced by RF-REPTree revealed that nearly 29% of the study areas have high to very high landslide susceptibility (LS). Statistical analysis of the model results included the receiver operating characteristic curve (ROC), the efficiency test, the true skill statistic (TSS), and the kappa index. ROC demonstrated that the AUC values of RF-REPTree, REPTree, J48, and NBTree models were 0.832, 0.700, 0.695, and 0.759 for succession rate curves and 0.794, 0.740, 0.788, and 0.728 for prediction rate curves, respectively. Therefore, all models were judged to be acceptably accurate for LSM. Among the LS models, the RF-REPTree model achieved the highest accuracy, followed by REPTree, J48, and NBTree. The results of LSM can be used to target the mitigation of landslide hazards and provide a foundation for sustainable environmental planning.