Miracle-dz/UniFAR-FTUs huggingface dataset:
A validated RP-HPLC method for simultaneous estimation of paracetamol and diclofenac potassiumin pharmaceutical formulation

A simple, selective, rapid, precise and economical reverse phase high pessure liquid chromatographic method has been developed for the simultaneous estimation of paracetamol and diclofenac potassiumfrompharmaceutical formulation. The method was carried out on a Phenomenex LUNAC18 (25cmiÂ´4.6mmi.d., 5iÂ­) columnwith amobile phase consisting of acetonitrile: sodium dihydrogen phosphate (adjusted to pH 3.5 using orthophosphoric acid) (70:30 v/v) at a flowrate of 1.0ml/min. Detectionwas carried out at 278nm. Aceclofenac was used as an internal standard. The retention time of paracetamol, diclofenac potassiumand aceclofenac was 5.9, 9.4 and 3.12min, respectively. The developedmethodwas validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation and solution stability. The proposed method can be used for the estimation of these drugs in combined dosage forms.
Epidemiology, pathogenesis, clinical findings and diagnosis of canine parvo viral infection – a mini review

Viral enteritis is one of the most common causes of infectious diarrhoea in dogs younger than six months age. Canine parvovirus (CPV)-2 and canine corona virus (CCoV) have been incriminated as primary pathogens (1). It is the number one viral cause of puppy enteritis and mortality (2). Unique properties of CPV make it an emerging and reemerging pathogen of dogs worldwide (3). Since its emergence in 1978, canine parvoviral enteritis remains a common and important cause of morbidity and mortality in young dogs. The continued incidence of parvoviral enteritis is partly due to the virus’s capability to “reinvent” itself and evolve into new, more virulent and resistant subspecies (4). This article briefly review about the current knowledge of epidemiology, pathogenesis, clinical findings and diagnosis of canine parvoviral enteritis. Epidemiology The virus
A 2/1 Sunitinib Dosing Schedule Provides Superior Antitumor Effectiveness and Less Toxicity Than a 4/2 Schedule for Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

Background: The standard sunitinib schedule to treat metastatic renal cell carcinoma (mRCC) is 4 weeks on/2 weeks off (4/2). However, some studies revealed intolerable adverse events (AEs) in patients on this schedule. An alternative schedule, 2 weeks on/1 week off (2/1), may overcome this issue. This meta-analysis was performed to compare the effectiveness and toxicity between the 2/1 and 4/2 sunitinib dosing schedules. Methods: We acquired relevant studies by searching PubMed, ScienceDirect, the Cochrane Library, Scopus, Ovid MEDLINE, Embase, Web of Science, and Google Scholar. Our main endpoints included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and AEs. Results: We identified 9 medium- and high-quality studies. Both schedules were effective for mRCC, with comparable OS and similar ORR. However, the 2/1 schedule had better PFS (hazard ratio (HR) = 0.81, 95% confidence interval [CI]: 0.66–0.99, P = 0.04), higher DCR [risk rate (RR) = 1.22, 95% CI: 1.01–1.47, P = 0.04] and fewer dosage interruptions (RR = 0.60, 95% CI: 0.43–0.84, P = 0.003). Additionally, the 2/1 schedule elicited fewer specific severe AEs, including thrombocytopenia/platelet disorder, hand-foot syndrome, hypertension, and fatigue. In our subanalysis, PFS was better among East Asians using the 2/1 schedule than among other populations (HR= 0.75, 95% CI: 0.58–0.98, P = 0.03), and patients administered an initial dosage of 50 mg/d on the 2/1 schedule had superior PFS (HR = 0.76, 95% CI: 0.59–0.97, P = 0.03) than those others. Conclusions: These findings suggest that the 2/1 schedule is more suitable for mRCC than 4/2, due to superior PFS, better DCR and fewer AEs. Nevertheless, more large-scale studies with good quality are needed.
The Effects of Inclusion of Exogenous Phospholipid in Tris-Diluent Containing a Different Level of Egg Yolk on the Viability of Bull Spermatozoa

SITUMORANG, P. 2002. The effects of inclusion of exogenous phospholipid in Tris diluent with different level of egg yolk on the viability of bull spermatozoa. JITV 7(3): 181-187. This study has been conducted to evaluate the effect of inclusion of phospholipid in Tris-diluent containing different level of egg yolk on the viability of bull spermatozoa after chilling and freezing. Semen was collected by means of artificial vagina, diluted in Tris-diluent to get a final concentration 100 x 10 spermatozoa/ml. Diluted semen was cooled to 5C for 45-60 minute, equiliberated in those temperature for 4 hours and frozen by placing the straw 5 cm above surface of liquid nitrogen for 10 minutes. The experiments was factorial designed with two level of phospholipid (0 and 0.5 mm) and 4 concentration of egg yolk (0, 5, 10 and 20% v/v). The viability of spermatozoa was assessed by evaluating the percentage of motile, live and condition of apical ridge after the temperature reduced to 5C, stored at those temperature for 3 and 7 days and after thawing. Inclusion of phospholipid and level of egg yolk in Tris diluent significantly increased the viability of spermatozoa for both chilling and deepfreezing. The mean percentage of motile, live and intact apical ridge for 3 and 7 days of storage times at 5C, were significantly higher (P<0.05) in diluent containing phospholipid than without phospholipid. After thawing, the mean percentage motile, live and intact apical ridges were significantly higher (P<0.05) in a diluent containing phospholipid (49.9; 60.2 and 60.0) than those without phospholipid (39.1; 54.1 and 51.5). The effects of interaction between phospholipid and level of egg yolk on the viability of spermatozoa was not significant for both chilling and freezing. Level of egg yolk significantly (P<0.05) affected the viability of spermatozoa where the optimal level of egg yolk was 10% v/v for chilled semen and the higher level (20% v/v) was needed for frozen semen. In conclusion, Tris diluent containing 0,5 mM phosphatidyl coline with 10 or 20% egg yolk gave a best protection for chilled and frozen semen respectively.
A SURVEY OF MENTAL DISORDERS USING HAIR CORTISOL CONCENTRATION

Depression is a severe, treatable disorder which continues to remain under-detected in the primary care settings and is associated with symptoms such as melancholy, loss of pleasure, loss of energy, difficulty in concentrating, and suicidal thoughts. Stressful life events are one of common precedents in the first episode of depression, and may leave a person more vulnerable to develop subsequent episodes. Various techniques such as psychological questionnaires, measuring cortisol concentration, MRI scanning have been employed to measure the severity of depression. The conventional sources to measure cortisol levels are plasma, urine or saliva, which provide only acute cortisol exposure. Measuring cortisol concentration in hair has emerged over recent years as it provides a longterm, month-bymonth systematic cortisol exposure. The purpose of this paper is to survey the promising results of correlation between HCC and mental disorders. A review of statistical techniques and machine learning algorithms used in previous work is included.
IMPACT OF TRAINING & DEVELOPMENT AND COMPETENCIES ON EMPLOYEES’ SWITCHING INTENTIONS: THE MODERATING EFFECT OF PSYCHOLOGICAL OWNERSHIP

In this study we try to explore the role of training and development programs in increasing the employees‟ competencies and ultimately their intentions to leave. Additionally, we also explore the moderating role of psychological ownership between the employees‟ competencies and intentions to leave the organizations. We select banking sector for data collection and use convenience sampling to collect data from respondents. Out of a total sample size of 88, we get useable responses from 59 respondents. Gender distribution of males and females in the sample is 67:12 respectively. We use correlation matrix and regression analysis to analyze the relationship between different variables. The results of the study reveal that training and development activities increase the employees‟ intentions to leave the organization if it has a weak system to retain its employees. Furthermore, employees with higher levels of psychological ownership may stay for longer periods with the organizations. The results of current study also suggest that organizations need to assess the employees‟ morale and satisfaction level on regular basis. By evaluating the satisfaction levels of employees on regular basis, organizations can avoid the cost of losing trained employees which ultimately can be helpful in improving the performance in long run.
Worldwide trends of forensic dentistry: a 20-year bibliometric analysis in Pubmed

The aim of this study was to evaluate the worldwide research productivity of forensic dentistry during the past 20 years (1996-2015) by bibliometric analysis. ‘‘Forensic Dentistry’’ was searched as the Medical Subject Headings term in PubMed and a total of 665 articles were retrieved. There were mainly 56 countries contributing to publications on forensic dentistry and the United States of America was the most productive country. 188 different journals were found and three journals were identified as core journals according to Bradford’s law. Personal identification was the most popular topic. The basic and recognized methodology applied in the present study provides a relative wide view on scientific productivity of forensic dentistry and allows us to understand this field better.
Performance Evaluation of some Routing Protocols using TCP Traffic Types in Mobile Ad Hoc Networks

Routing is a critical issue in a Mobile Ad-hoc Network (MANET). The most famous MANET routing protocols are AODV, DSDV, DSR and AOMDV. Although the performance evaluation of these routing protocols have been extensively simulated, most of the researchers are focusing on the User Datagram Protocol (UDP) traffic type supposing that the Transmission Control Protocol (TCP) sources offers a conforming load to the network. Despite of this, most Internet applications are carried out through TCP. In this paper, we investigate the performance of AODV, DSDV, DSR and AOMDV routing protocols using TCP traffic types such as TCP-Reno, TCP-Newreno, TCP-Vegas and TCP-Sack. The performance analysis is done in terms of packet delivery ratio, average end to end delay and average throughput using the NS2 simulator. The simulation results show that TCP-Vegas performs better compared with others in the case of end-to-end delay, and has higher packet delivery ratio. The TCP-Reno has higher throughput in the case of low data connections compared with TCP-Newreno, TCP-Vegas and TCP-Sack. In case of high data connections the TCP-Vegas have the higher throughput compared with the others.
Premature ventricular complexes (PVC)-induced cardiomyopathy: A review and meta-analysis of pathophysiology, diagnosis and clinical management

Frequent premature ventricular complexes (PVC) is a common cardiac entity in patients with structural heart disease and PVC-induced cardiomyopathy (PICM). It is also common in asymptomatic patients, where it is considered a benign entity with no prognostic implications. In patients with structural heart disease, the presence of PVCs can result in fatal ventricular arrhythmias. Various cellular and extracellular mechanism as well as risk factors for developing PICM have been suggested but the exact mechanisms remains unclear. The increasing insights into the treatment of ventricular tachyarrhythmias, especially the introduction of radiofrequency catheter ablation in clinical practice has renewed interest in PVCs as predictors of arrhythmias as well as their potential aetiological association with CM. The present paper reviews existing evidence on PICM patients with a focus on prevalence, risk factors, pathophysiology, clinical presentation, concluding with and a meta-analysis and discussion of current diagnostic and treatment criteria. *Correspondence to: Aref Albakri, St-Marien hospital Bonn Venusberg, department of Internal Medicine, Bonn, Germany, E-mail: arefalbakri@yahoo.com
An Interdisciplinary Approach to Study the Performance of Second-generation Genetically Modified Crops in Field Trials: A Case Study With Soybean and Wheat Carrying the Sunflower HaHB4 Transcription Factor

Research, production, and use of genetically modified (GM) crops have split the world between supporters and opponents. Up to now, this technology has been limited to the control of weeds and pests, whereas the second generation of GM crops is expected to assist farmers in abiotic stress tolerance or improved nutritional features. Aiming to analyze this subject holistically, in this presentation we address an advanced technology for drought-tolerant GM crops, upscaling from molecular details obtained in the laboratory to an extensive network of field trials as well as the impact of the introduction of this innovation into the market. Sunflower has divergent transcription factors, which could be key actors in the drought response orchestrating several signal transduction pathways, generating an improved performance to deal with water deficit. One of such factors, HaHB4, belongs to the homeodomain-leucine zipper family and was first introduced in Arabidopsis. Transformed plants had improved tolerance to water deficits, through the inhibition of ethylene sensitivity and not by stomata closure. Wheat and soybean plants expressing the HaHB4 gene were obtained and cropped across a wide range of growing conditions exhibiting enhanced adaptation to drought-prone environments, the most important constraint affecting crop yield worldwide. The performance of wheat and soybean, however, differed slightly across mentioned environments; whereas the improved behavior of GM wheat respect to controls was less dependent on the temperature regime (cool or warm), differences between GM and wild-type soybeans were remarkably larger in warmer compared to cooler conditions. In both species, these GM crops are good candidates to become market products in the near future. In anticipation of consumers’ and other stakeholders’ interest, spectral analyses of field crops have been conducted to differentiate these GM crops from wild type and commercial cultivars. In this paper, the potential impact of the release of such market products is discussed, considering the perspectives of different stakeholders.
AN ANALYTICAL STUDY OF MAGNETOHYDRODYNAMICAL FLUID FLOW UNDER THE EFFECT OF MICROROTATION

This Paper presents the study of the MHD effects on the unsteady boundary layer flow of an incompressible micropolar fluid over a stretching sheet when the sheet is stretched in its own plane. The stretching velocity is assumed to vary linearly with the distance along the sheet. Two equal and opposite forces are impulsively applied along − x axis so that the sheet is stretched, keeping the origin fixed in a micropolar fluid. The governing non-linear equations and their associated boundary conditions are first cast into dimensionless form by a local non-similarity transformation. The resulting equations are solved numerically using the AdamsPredictor Corrector method for the whole transient from the initial state to final steadystate flow. Numerical results are obtained and a representative set is diaplaced graphically to illustrate the influence of the various physical parameters on the velocity profiles, microrotation profiles as well as the Skin friction coefficient for various values of the material parameter K. It is found that there is a smooth transition from the smalltime solution to the largetime solution. Results for the local skin friction coefficient are presented in table as well as in graph.
The Low Blood Level of 25-Hydroxy Vitamin D in African American Women: Is It Clinically Significant?

After vitamin D (also called cholecalciferol) is synthesized in the skin, it is metabolized to 25(OH)D (25-hydroxyvitamin D, also called calcidiol) in the liver and then to the biologically active form, 1,25(OH)2D (1,25-dihydroxyvitaminD, also called calcitriol)in the kidney. According to the guidelines of the Endocrine Society, vitamin D deficiency is defined as a blood level of 25(OH)D of 20 ng/ml or lower, and with this definition an estimated 42% to 82% of African Americans are considered vitamin D deficient. However, there is no concrete evidence of higher-than-normal rates of common disorders of vitamin D deficiency within the African American population. Our review of independent studies clearly shows that although the mean blood levels of 25(OH)D in African American women are in the deficient range, the mean blood levels of 1,25(OH)2D in African American women are unequivocally in the normal rangeand that African American women of different age groups also maintain normocalcemia (normal blood calcium level). Furthermore, although oral supplementation of high doses of vitamin D to African American women increases their blood levels of 25(OH)D to the normal range, there is no health benefits of the supplementation when bone health is concerned. Therefore, it appears that African American women are functionally vitamin D sufficient given that they have normal blood levels of 1,25(OH)2D, and the blood 25(OH) D level may not be the best marker of vitamin D sufficiency or deficiency in African American women. In the future, it will be critical to investigate if there are specific genetic factors that enable African American women to maintain normal blood levels of 1,25(OH)2D and bone health despite having low blood levels of 25(OH)D.
Formulation, Design and Optimization of Orodispersible Tablets of Atenolol

The purpose of this research was to develop orodispersible tablets of atenolol. Tablets containing atenolol, camphor, kyron-T 314, and lactose were prepared by direct compression technique. Camphor was sublimed by exposure of tablet to vacuum. The tablets were evaluated for percentage friability, wetting time, and disintegration time. In the investigation, a 3 full factorial design was used to investigate the joint influence of two formulation variables: amount of camphor and kyron-T314 (superdisintegrant). The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using an optimum concentration of camphor and a higher percentage of kyron-T 314. A Response Surface Plot is presented graphically to represent the effect of the independent variables on the disintegration time and percentage friability. A checkpoint batch was also prepared to prove the validity of the evolved mathematical model. The systematic formulation approach helped in understanding the effect of formulation processing variables.
Patient selection protocols for endoscopic transforaminal, interlaminar, and translaminar decompression of lumbar spinal stenosis.

Background The indications of different endoscopic and endoscopically assisted translaminar approaches for lumbar spinal stenosis are not well-defined, and validated protocols for the use of the transforaminal over the interlaminar approach are lacking. Methods We performed a retrospective study employing an image-based patient stratification protocol of stenosis location (type I-central canal, type II-lateral recess, type III-foraminal, type IV-extraforaminal) and clinical outcomes on 249 patients consisting of 137 (55%) men and 112 (45%) women with an average age of 56.03±16.8 years who underwent endoscopic surgery for symptomatic spinal stenosis from January 2013 to February 2019. The average follow-up of 38.27±27.9 months. The primary clinical outcome measures were the Oswestry Disability Index (ODI), Visual Analogue Scale (VAS), and modified Macnab criteria. Results The frequency of stenosis configuration in decreasing order was as follows: type I-121/249; 48.6%, type III-104/249; 41.8%, type II-15/249; 6%, and type IV-9/249; 3.6%. The transforaminal approach (137/249; 55.0%) was used in most type II to IV lesions followed by the interlaminar approach (78/249; 31.3%), and the full endoscopic approach (12/249; 4.8%), and the endoscopically assisted translaminar approach (8/249; 3.2%) which was exclusively used for type I lesions. Macnab outcomes analysis showed Excellent in 47 patients (18.9%), Good in 178 (71.5%), Fair in 18 (7.2%) and Poor in 6 (2.4%), respectively. Paired two-tailed t-test showed statistically significant VAS (5.46±2.1; P<0.0001) and ODI (37.1±16.9; P<0.0001) reductions as a result of the endoscopic decompression surgery. Cross-tabulation of the Macnab outcomes versus the endoscopic approach and surgical technique confirmed beneficial association of the approach selection with Excellent (P=0.001) and Good (P<0.0001) outcomes with statistically significance. Conclusions This study suggests that in the hands of skilled endoscopic spines surgeon use of an image-based stenosis location protocol may contribute to obtaining Excellent and Good clinical outcomes in a high percentage (93%) of patients suffering from lumbar stenosis related radiculopathy. Additional comparative studies should examine the prognostic value of choosing the endoscopic approach on the basis of the proposed four-type stenosis protocol by correlating its impact on outcomes with preoperative diagnostic injections and intraoperative direct visualization of symptomatic pain generators under local anesthesia and sedation.
EFFECT OF TOTAL QUALITY MANAGEMENT ON CUSTOMER SATISFACTION

DOI: 10.5281/zenodo.55618 ABSTRACT Purpose: The purpose of this research is to provide an intermediate step to understanding the complex relationship between total quality management and customer satisfaction. This study presents research which examines the structural relationship between quality management and customer satisfaction in Korea. Specifically, the effects of quality management, employee engagement, continuous improvement, and customer satisfaction are tested. We examined the research model and the research hypotheses basis for applying TQM theories.
COMPARATIVE STUDY OF THE IMPACT OF PROFESSIONAL ETHICS EDUCATION USING LECTURE AND MULTIMEDIA SOFTWARE ON KNOWLEDGE OF NURSING STUDENTS

: Not specified pattern for ethics curriculum will be a lot of features, skills and abilities that should not be neglected in terms of ethics curriculum. The aim of this study was to determine the impact of professional ethics education using lecture and multimedia software based on knowledge of nursing students in the field of professional ethics. A quasi-experimental study of two groups before and after nursing and population were students of the School of Nursing and Midwifery of Hamedan University of Medical Sciences Semester 4 and 6 that were trained in two groups and multimedia presentations. First, all students are then assigned to two groups arrived census and number of samples in each group was 30. Test before training, immediately after training using the standard professional ethics of nurses. Data using the t test and analysis of variance for repeated measures analysis software SPSS version 20 were analyzed. The mean score of knowledge in multimedia 14.53 and 13.61 respectively in group discussion. But the difference was not significant between the two groups in terms of multimedia group had higher scores. The findings show that there are significant differences ethics education both lecture and multimedia to enhance learning in the nursing students but this is about more than lecture method was multi-media approach, so we can use both methods, especially methods of presentation used for training professional ethics of nursing.