Miracle-dz/UniFAR-FTUs huggingface dataset:
Automated Design of a Tension Leg Platform with Minimized Tendon Fatigue Damage and its Verification by a Fully Coupled Analysis

Abstract This paper presents the efficient hull shape of a Tension Leg Platform (TLP) developed by a fully automated hull optimization procedure. Optimization algorithms vary selected form parameters of the desired hull shape and find an optimum of the objective function within the provided constraints ensuring the resulting design to be technically feasible. As an initial design, a TLP installed in the Gulf of Mexico was is selected for the hull shape optimization. The TLP hull shape was optimized with regard to fatigue damage of the most loaded tendon due to top tension. The resulting design shows remarkably enhanced design qualities with minimized wave loads and motions as well as fatigue damage compared to the initial design. As a verification, the improved hydrodynamic performance of the optimized hull shape of TLP was investigated by a fully coupled time domain dynamic analysis considering second-order wave forces and nonlinear viscous forces as well as nonlinear tendon dynamics.
Platform loading from explosions in saturated sand using a visco-plastic model

A set of experiments were conducted at the Aberdeen Proving Grounds 1 (Taylor, L.C., Skaggs, R.R. and Gault, W., 2005. Vertical impulse measurements of mines buried in saturated sand. Proceedings of the 31st Annual Conference on Explosives and Blasting Technique, Orlando, FL, 6 – 9 February, 2.) in which explosive charges were buried in saturated sand beneath a suspended rigid platform. The goal of these experiments was to measure the dependence of the impulse transmitted to the platform on the standoff distance and the charge burial depth. Simulations of these experiments were performed using the BUB2D axi-symmetric code using a frictional-cohesive visco-plastic model to describe the response of the saturated sand. This code solves a constrained set of conservation laws in which the liquid region (in this case saturated sand) is assumed incompressible. The explosion is initialized as a high pressure gas bubble (void) within the fluid. Comparisons of the simulations to the experiments are presented togeth.
Electronic government public value of public institutions in Jordan

Substantially, the theory of e-government public value (PV-EGOV) has been treated as a hot topic to be explored insightfully. This research comes to be considered as the launching point to empirically evaluate the creation of PV-EGOV in Jordan. The main aim of this research is to investigate the factors affecting the PV-EGOV in the context of Jordan. Information System Success Model (IS success model) was selected to determine the factors affecting the e-government public value in Jordan through the quality factors (system, information, and service) and their role in citizens' intention in use and satisfaction of the e-government. The structural Equation Model (SEM) approach was harnessed to obtain the results. The results indicated that the most critical determinant factor that affected the PV-EGOV was service quality. The current article has theoretical and practical implications for public institutions in Jordan. The future work trends are established in their specific section of this article.
A profile on capmatinib in treating adult patients with metastatic NSCLC tumors with MET exon 14 skipping mutations

ABSTRACT Introduction : Clinical studies of MET-targeted treatments have so far failed to provide adequate outcomes. Capmatinib, a newly designed MET receptor inhibitor, has demonstrated considerable anticancer efficacy in patients with advanced NSCLC who have a MET exon 14 skipping mutation. Areas covered : This review offers a summary of the findings from capmatinib clinical studies in NSCLC patients with a MET exon 14 skipping mutation, as well as preclinical data and post-market reporting of capmatinib. Expert opinion : Capmatinib has a tolerable safety profile and preliminary evidence of effectiveness in patients with a MET exon 14 skipping mutation, according to data from a phase 1 clinical study. The GEOMETRY mono-1 phase 2 study revealed objective response rates of 68% and 41%, and median OS of 20.8 and 13.6 months in treatment-naive and pretreated MET exon 14 skipping mutant patients, respectively. Furthermore, capmatinib penetrates the blood–brain barrier, and capmatinib activity in the brain was shown to be encouraging in the study. However, the effectiveness of immunotherapy for MET exon 14 skipping mutation remains debatable. To enhance therapy choices, researchers have begun to focus on the mechanisms of intrinsic and acquired resistance of the MET exon 14 skipping mutation.
Impact of balanced and unbalanced direct current bias on harmonic distortion generated by asymmetric three-phase three-leg transformers

The impacts of dc bias and (un)balanced operation including tank effects on harmonic distortions generated by three-phase three-leg transformers are studied. Phase imbalances in power networks can arise from unbalanced loads, imperfections in the transposition of long transmission lines and asymmetry in the structure of transformer cores. When coupled with dc biases, such as those generated by geomagnetically induced currents, the current harmonic distortion in three-phase three-leg transformers can increase significantly. A detailed theoretical study based on electromagnetic theory is performed to explain this phenomenon. A time-domain model of a non-linear three-phase three-leg transformer considering magnetic coupling and core structure asymmetry under (un)balanced dc bias is implemented. Theoretical predictions are confirmed by simulation results which are further supported by experimental tests. The main contribution of this study is a new analysis explaining the link between dc bias and (un)balanced operation on the generation of harmonic distortion in three-phase three-leg transformers.
Multi‐objective optimisation and multi‐criteria decision making in SLS using evolutionary approaches

Purpose – The goal of this study is to carry out multi‐objective optimization by considering minimization of surface roughness (Ra) and build time (T) in selective laser sintering (SLS) process, which are functions of “build orientation”. Evolutionary algorithms are applied for this purpose. The performance comparison of the optimizers is done based on statistical measures. In order to find truly optimal solutions, local search is proposed. An important task of decision making, i.e. the selection of one solution in the presence of multiple trade‐off solutions, is also addressed. Analysis of optimal solutions is done to gain insight into the problem behavior.Design/methodology/approach – The minimization of Ra and T is done using two popular optimizers – multi‐objective genetic algorithm (non‐dominated sorting genetic algorithm (NSGA‐II)) and multi‐objective particle swarm optimizers (MOPSO). Standard measures from evolutionary computation – “hypervolume measure” and “attainment surface approximator” have .
What drives millennials and zillennials continuously using instant messaging? Perspective from Indonesia

This study proposes to explore the relationship between perceived risk, subjective norm, perceived value, and continuous usage intention via trust as a mediating variable. This research applied a survey which involved 320 IM users (160 from millennials and 160 from Zillennial) in Indonesia. The literature’s existing scales were used to operationalize the constructs proposed in this study. The analyses were conducted using partial least squares structural equation modeling (PLS-SEM) to test hypotheses. The results of the study show that there are differences in the results of the influence of perceived risk on continuous usage intention in the Millennial and Zillennial generations. The results of the study found that continuous usage intention received negative direct impact from perceived risk, positive direct effect from subjective norm, perceived value, and trust on Millennial. In addition, continuous usage intention received negative and not significant direct impact from perceived risk, positive direct effect from subjective norm, perceived value, and trust on Zillennial. The results are useful for instant messaging management into formulating strategies to retain their users in Indonesia. These findings provided theoretical and managerial contributions as well as future research directions.
A Study on Potential Progressive Collapse Responses of Cable-Stayed Bridges

In this paper, a finite element (FE) model for a cable-stayed bridge designed according to Australian standards is developed and analysed statically and dynamically with and without geometrical nonlinearities. The dynamic amplification factor (DAF) and demand-to-capacity ratio (DCR) in different structural components including cables, towers and the deck are calculated and it is shown that DCR usually remains below one (no material nonlinearity occurs) in the scenarios studied for the bridge under investigation, however, DAF can take values larger than two. Moreover, effects of location, duration and number of cable(s) loss as well as effect of damping level on the progressive collapse resistance of the bridge are studied and importance of each factor on the potential progressive collapse response of the bridgeis investigated.
Influence of Resin Cement Thickness and Elastic Modulus on the Stress Distribution of Zirconium Dioxide Inlay-Bridge: 3D Finite Element Analysis

The mechanical properties and the thickness of the resin cement agents used for bonding inlay bridges can modify the clinical performance of the restoration such as debonding or prosthetic materials fracture. Thus, the aim of this study was to evaluate the stress distribution and the maximum strain generated by resin cements with different elastic moduli and thicknesses used to cement resin-bonded fixed partial denture (RBFPD). A three-dimensional (3D) finite element analysis (FEA) was used, and a 3D model was created based on a Cone-Beam Computed Tomography system (CBCT). The model was analyzed by the Ansys software. The model fixation occurred at the root of the abutment teeth and an axial load of 300 N was applied on the occlusal surface of the pontic. The highest stress value was observed for the Variolink 0.4 group (1.76 × 106 Pa), while the lowest was noted for the Panavia 0.2 group (1.07 × 106 Pa). Furthermore, the highest total deformation value was found for the Variolink 0.2 group (3.36 × 10−4 m), while the lowest was observed for the Panavia 0.4 group (2.33 × 10−4 m). By means of this FEA, 0.2 mm layer Panavia F2.0 seemed to exhibit a more favorable stress distribution when used for cementation of posterior zirconium-dioxide-based RBFPD. However, both studied materials possessed clinically acceptable properties.
Power Tool for Countering Cyberwar: Visualizations for Information Assurance and Computer Network Defense

There has been a growing need for military decision-makers to maintain the integrity of the information contained within their computer network. Tools to support Information Assurance and Computer Network Defense (IA-CND) are needed to defend their information infrastructure and conduct Computer Network Operations with a new level of insight and understanding. This paper describes one effort to develop visualizations to aid these decision-makers in the highly abstract, complex and dynamic mission of IA-CND. This paper describes the development of a IA-CND Communications Display. Using a Cognitive Systems Engineering methodology, this project transitioned from a broad description of a work domain, to the development of decision aiding concepts for a particular portion of that domain. This methodology also provided a means to develop breakthrough support for a decision difficult domain.
Characterization of the In Vitro and In Vivo Efficacy of Baloxavir Marboxil against H5 Highly Pathogenic Avian Influenza Virus Infection

Human infections caused by the H5 highly pathogenic avian influenza virus (HPAIV) sporadically threaten public health. The susceptibility of HPAIVs to baloxavir acid (BXA), a new class of inhibitors for the influenza virus cap-dependent endonuclease, has been confirmed in vitro, but it has not yet been fully characterized. Here, the efficacy of BXA against HPAIVs, including recent H5N8 variants, was assessed in vitro. The antiviral efficacy of baloxavir marboxil (BXM) in H5N1 virus-infected mice was also investigated. BXA exhibited similar in vitro activities against H5N1, H5N6, and H5N8 variants tested in comparison with seasonal and other zoonotic strains. Compared with oseltamivir phosphate (OSP), BXM monotherapy in mice infected with the H5N1 HPAIV clinical isolate, the A/Hong Kong/483/1997 strain, also caused a significant reduction in viral titers in the lungs, brains, and kidneys, thereby preventing acute lung inflammation and reducing mortality. Furthermore, compared with BXM or OSP monotherapy, combination treatments with BXM and OSP using a 48-h delayed treatment model showed a more potent effect on viral replication in the organs, accompanied by improved survival. In conclusion, BXM has a potent antiviral efficacy against H5 HPAIV infections.
Dynamic soil–structure interaction effects on the seismic response of suspension bridges

A stochastic approach has been formulated for the linear analysis of suspension bridges subjected to earthquake excitations. The transfer functions of various responses have been formulated while including the effects of dynamic Soil-Structure Interaction (SSI) via the use of the fixed-base modes of the structure. The excitation has been characterized by the 'equivalent stationary' processes corresponding to the free-field motions at each support and by an assumed coherency function between these motions. The proposed formulation considers the non-stationarity in the structural response due to sudden application of excitation by considering (i) the time-dependent frequency response functions, and (ii) the order statistics formulation for the peak factors in evolutionary response processes. The formulation has been illustrated by analysing the seismic response of the Golden Gate bridge at San Francisco for two example excitations conforming to USNRC-specified design spectra. The significance of various governing parameters on the dynamic soil-structure interaction effects on the seismic response of suspension bridges has also been studied. It has been found that the contribution of the vertical component of ground motion to the bridge response increases with increasing soil compliance. Also, the extent to which the spatial variation of ground motion affects the bridge response depends on how significant the SSI effects are.
Routing and scheduling hazardous material shipments: Nash game approach

The shipment of hazardous materials (hazmats) received considerable attention as the consequences of the incidents, including environmental pollution, economic damage, injuries, and fatalities are extremely undesirable. Previous research mainly focused on the shipment of hazmats under known link incident probabilities. Using the Nash game theory approach, this paper studies the integrated routing and scheduling hazmat shipment problem with unknown link incident probabilities. The problem is formulated as a route-based maxmin problem over the space–time expanded network proposed in this paper. This route-based problem is decomposed into a link-based linear problem so that linear programming solution methods can be adopted. To solve for solutions, this paper proposes two methods. The convergences of these methods are discussed. A numerical example is provided to illustrate the two proposed methodologies and the solution properties of the maxmin problem. The implications of these solution properties are also discussed. This approach helps find critical links over a time–space hazmat shipment network.
Hurricane Mitigation Status and Factors Influencing Mitigation Status among Florida’s Single-Family Homeowners

This paper presents statewide estimates of shutter usage and envelope coverage for owner-occupied single-family detached housing in Florida. Intrastate regional variations are also presented and discussed. Multivariate analyses of shutter and envelope coverage assessing the relative influence of a variety of factors considered by the literature to be determinants of household mitigation are presented. The findings suggest that perceptions of hurricane risk and knowledge, past hurricane experience, proportion of neighbors with shutters, residing in coastal counties and counties subscribing to the South Florida Building Code, household income, and race/ethnicity are all significant determinants of shutter usage and envelope coverage. Policy implications are discussed.
Motor nerve conduction study parameters in healthy individuals: effect of limb dominance

Background: Nerve conduction study (NCS) is useful for evaluation of nerve, muscle, and/or neuromuscular function. Neurophysiologist interprets NCS with consideration of various anthropometric and technical parameters viz. age, gender, height, temperature etc. apart from the underlying pathology. Fewer studies have reported the effect of limb dominance on NCS. Moreover, the findings are controversial. Therefore, author aimed to investigate the effect of limb dominance on motor nerve conduction study parameters.Methods: This cross-sectional comparative study included sixty healthy individuals (44 right and 16 left handed) of either sex with age 18 to 30 years. The NCS parameters of median and ulnar nerves were assessed by stimulating it and recording from the muscle and skin overlying the nerve respectively using Digital Nihon Kohden machine. The obtained data were analyzed using independent sample t-test.Results: Right ulnar nerve onset latency was significantly longer in left-handed individuals (1.85±0.508 ms vs 1.62±0.195 ms, p=0.012). The left ulnar nerve F wave minimum latency (25.88±0.74 ms vs 24.46±2.64 ms, p=0.002) was significantly longer in left-handed individuals. Likewise, right ulnar nerve distal latency (2.45±0.76 ms vs 2.14±0.39 ms, p=0.044), and right ulnar nerve F wave minimum (25.9±1.21 ms vs 24.85 ms±1.74, p=0.030) were significantly high in left-handed individuals.Conclusions: NCS parameters in terms of latencies were longer in left-handed individuals. Therefore, limb dominance seems to be an important factor one should pay attention during bilateral comparison of obtained data in neurophysiological reporting of referred cases.
Developing a Stabilizing Formulation of a Live Chimeric Dengue Virus Vaccine Dry Coated on a High-Density Microarray Patch

Alternative delivery systems such as the high-density microarray patch (HD-MAP) are being widely explored due to the variety of benefits they offer over traditional vaccine delivery methods. As vaccines are dry coated onto the HD-MAP, there is a need to ensure the stability of the vaccine in a solid state upon dry down. Other challenges faced are the structural stability during storage as a dried vaccine and during reconstitution upon application into the skin. Using a novel live chimeric virus vaccine candidate, BinJ/DENV2-prME, we explored a panel of pharmaceutical excipients to mitigate vaccine loss during the drying and storage process. This screening identified human serum albumin (HSA) as the lead stabilizing excipient. When bDENV2-coated HD-MAPs were stored at 4 °C for a month, we found complete retention of vaccine potency as assessed by the generation of potent virus-neutralizing antibody responses in mice. We also demonstrated that HD-MAP wear time did not influence vaccine deposition into the skin or the corresponding immunological outcomes. The final candidate formulation with HSA maintained ~100% percentage recovery after 6 months of storage at 4 °C.
Semiconductor physics Nanostructured SiC as a promising material for the cold electron emitters

In this paper, the novel cold electron emitters based on nanostructured SiC layers covering the Si(001) substrate have been proposed. Their main advantage is an extremely simple and cost-effective manufacturing process based on the standard microelectronics-grade silicon wafers with no ultra-high vacuum required and no complicated chemical deposition processes or toxic chemicals involved. It integrates within a single technological step both the SiC growth and nanostructuring the surface in the form of nanosized protrusions, which is extremely beneficial for cathode applications. A simple mathematical model predicts field emission current densities and turn-on electric fields, which would allow practical device applications. According to our estimations, emission currents in the milli-Amp range can be harvested from one square centimeter of the cathode surface with electric field close to 10 7 V/m. So, the nanostructured SiC can be the promising material for the cold electron emitters.
Random Data: Analysis and Measurement Procedures

From the Publisher: A revised and expanded edition of this classic reference/text, covering the latest techniques for the analysis and measurement of stationary and nonstationary random data passing through physical systems. With more than 100,000 copies in print and six foreign translations, the first edition standardized the methodology in this field. This new edition covers all new procedures developed since 1971 and extends the application of random data analysis to aerospace and automotive research; digital data analysis; dynamic test programs; fluid turbulence analysis; industrial noise control; oceanographic data analysis; system identification problems; and many other fields. Includes new formulas for statistical error analysis of desired estimates, new examples and problem sets.
Effects of interstitial oxygen defects at HfO/sub x/N/sub y//Si interface on electrical characteristics of MOS devices

Effects of the defects at high-/spl kappa/ dielectric/Si interface on the electrical characteristics of MOS devices are important issues. To study these issues, a low defect (denuded zone) at Si surface was formed by a high-temperature annealing in hydrogen atmosphere in this paper. Our results reveal that HfO/sub x/N/sub y/ demonstrates significant improvement on the electrical properties of MOS devices due to its low amount of the interstitial oxygen [O/sub i/] and the crystal-originated particles defects as well as small surface roughness at HfO/sub x/N/sub y//Si interface. The current-conduction mechanism of the HfO/sub x/N/sub y/ film at the low- and high-electrical field and high-temperature (T>100/spl deg/C) is dominated by Schottky emission and Frenkel-Poole (FP) emission, respectively. The trap energy level involved in FP conduction was estimated to be around 0.5eV. Reduced gate leakage current, stress-induced leakage current and defect generation rate, attributable to the reduction of defects at HfO/sub x/N/sub y//Si interface, were observed for devices with denuded zone. The variable rise and fall time bipolar-pulse-induced current technique was used to determine the energy distribution of interface trap density (D/sub it/). The results exhibit that relatively low D/sub it/ can be attributed to the reduction of defects at Si surface. By using denuded zone at the Si surface, HfO/sub x/N/sub y/ has demonstrated significant improvement on electrical properties as compared to SiO/sub x/N/sub y/.