Miracle-dz/UniFAR-FTUs huggingface dataset:
Dosing interval adjustment of denosumab for the treatment of giant cell tumor of the sphenoid bone: A case report

Background: In the treatment of giant cell tumor of bone (GCTB), the efficacy and safety of denosumab, a receptor activator nuclear factor κ-B ligand inhibitor, has previously been demonstrated, especially for unresectable tumors. One of the current issues in denosumab treatment for unresectable GCTB is whether it can be discontinued, or whether the dosage or the dosing interval can safely be adjusted, if discontinuation is not possible, to avoid the occurrence of side effects. Case Description: A 15-year-old boy with diplopia was referred to our hospital after a space-occupying lesion in the sphenoid bone was found on head CT. Partial removal of the tumor was performed through an endoscopic endonasal approach, and pathological diagnosis was confirmed as GCTB. Thereafter, the patient received 120 mg subcutaneous injections of denosumab every 28 days for the first 2 years. Since bone formation was induced and sustained along with tumor reduction, the dosing interval was gradually extended, with 4 monthly dosing for the next 1 year, followed by 6 monthly dosing for the succeeding 2 years. With the extension of the dosing interval, the ossified tumor has regrown slightly, but within an acceptable range. Conclusion: Discontinuation of denosumab treatment for unresectable GCTB was not thought to be possible for the current case due to the nature of the drug, as reported in the literature. Extending the dosing interval up to 6 monthly, as could be done safely in the current case, can be considered a useful and appropriate measure.
The Symbiotic Bond of Income Equality and Organizational Equilibrium

The corporate sustainability literature postulates that companies are social entities that constantly interact with the society in which they are located. Although this idea is generally accepted, one persistent research gap in this field relates to testing this connection through quantitative empirical studies. In this study, we shed light on the bidirectional relationship between income inequality and organizational equilibrium (i.e., balance in the employment relationship). From data on 2525 companies covering a nine-year period and using longitudinal structural equation modeling, findings demonstrate that equity in the distribution of resources among people in a society positively influences equity in the distribution of resources between employer and employees, and vice versa. A symbiotic union of mutual benefit between society and business is, therefore, developed over time. Theoretical and practical implications of our findings are presented.
Состояние популяционного иммунитета к кори в России: систематический обзор и метаанализ эпидемиологических исследований

Introduction . The comprehensive assessment of the herd immunity to measles in Russia can be challenging, as Russian subject-related studies tend to focus on seroprevalence in various cohorts of different sizes. The systematic review and subsequent meta-analysis of different research findings increase the total number of observations and statistical significance of the studies, thus enhancing the reliability of conclusions. The purpose of the study is to assess the status of herd immunity to measles in Russia by analyzing the findings of studies published by Russian researchers. Materials and methods . The conducted systematic review and meta-analysis covered 13 Russian studies (the total number of the examined was 15,353, from birth to 79 years of age) published in 2011-2020 and addressing the assessment of herd immunity to measles in population of different regions in Russia. Results. It was found that the principal approach in all the studies was assessment of herd immunity through examination of adult people, including healthcare workers, with no regard for their vaccination history. The proportion of seronegative cases among young people (18-30 years) — 27.3% (95% CI 25.7-27.3%) and among children under 17 — 38.3% (95% CI 35.8-40.8%), who were born after the two-time vaccination had been included in the National Immunization Calendar, was larger than in older age groups — 19.8% (95% CI 17.8¬21.8%). The level of herd immunity among healthcare workers representing a decreed group — 84.5% (95% CI 83.7-85.3%) was higher than that of relatively healthy population — 75.4% (95% CI 74.1-76.6%), which can be explained by stricter vaccination requirements. Conclusion. The high proportion of seronegative cases among children and young adults of under 30 years of age is a risk factor associated with measles spread among the population and can be seen as the result of insufficient vaccination coverage.
Pelletization of Post-Harvest Tobacco Waste and Investigation of Flue Gas Emissions from Pellet Combustion

The paper presents the results of the pelletization (agglomeration) tests of post-harvest tobacco waste as a feedstock for fuel pellet production. The experiment was conducted on a prototype pelleting–briquetting device with a flat matrix. The influence of the tobacco waste moisture content (17, 21 and 25wt.%) and the rotational speed of the agglomerating rolls (120, 170 and 220 rpm) on the power demand and on the pellet’s kinetic durability and density were determined. It was found that the moisture content has a significant impact on the pellet’s density but slightly affects its kinetic durability. The obtained pellets were characterized by a high density above 1000 kg·m−3 and kinetic durability above 97%. In order to examine the exhaust composition, the obtained pellets were combusted in a 25 kW fixed great boiler. High amounts of CO, SOx, NO and HCl were obtained, which suggests that the selection of a different technology for tobacco waste pellet combustion should be made.
Habitat features and colony characteristics influencing ant personality and its fitness consequences

Abstract Several factors can influence individual and group behavioral variation that can have important fitness consequences. In this study, we tested how two habitat types (seminatural meadows and meadows invaded by Solidago plants) and factors like colony and worker size and nest density influence behavioral (activity, meanderness, exploration, aggression, and nest displacement) variation on different levels of the social organization of Myrmica rubra ants and how these might affect the colony productivity. We assumed that the factors within the two habitat types exert different selective pressures on individual and colony behavioral variation that affects colony productivity. Our results showed individual-/colony-specific expression of both mean and residual behavioral variation of the studied behavioral traits. Although habitat type did not have any direct effect, habitat-dependent factors, like colony size and nest density influenced the individual mean and residual variation of several traits. We also found personality at the individual-level and at the colony level. Exploration positively influenced the total- and worker production in both habitats. Worker aggression influenced all the productivity parameters in seminatural meadows, whereas activity had a positive effect on the worker and total production in invaded meadows. Our results suggest that habitat type, through its environmental characteristics, can affect different behavioral traits both at the individual and colony level and that those with the strongest effect on colony productivity primarily shape the personality of individuals. Our results highlight the need for complex environmental manipulations to fully understand the effects shaping behavior and reproduction in colony-living species.
Overall Reduced Baseline Lymphocyte Subsets Closely Related to the Poor Prognosis and the Disease Severity in Patients With COVID-19 and Diabetes Mellitus

IntroductionDysregulated host immune response was common in COVID-19. In this study we aimed at the characteristics of lymphocyte subsets and its relationship with the disease progression in COVID-19 patients with or without DM.MethodsThe baseline peripheral lymphocyte and subsets were compared between 55 healthy cases (control group) and 95 confirmed cases with COVID-19 (COVID-19 group), and between COVID-19 patients with and without DM.ResultsThe prevalence of DM in COVID-19 group was 20%, and severe cases had higher the prevalence of DM than non-severe cases (P=0.006), moreover significantly poor prognosis and higher severe rate were found in those with DM relative to those without DM (P=0.001,0.003, respectively). In COVID-19 group overall and significant reduced lymphocyte and subsets, especially B and T lymphocytes were found, especially in those with DM. Partial decreased lymphocyte subsets, age and DM closely related with the disease progression and the prognosis.ConclusionsThese findings provide a reference for clinicians that immunomodulatory treatment maybe improve disease progression and prognosis of COVID-19 patients, especially those with DM.
Quantifying Long‐Term Seasonal and Regional Impacts of North American Fire Activity on Continental Boundary Layer Aerosols and Cloud Condensation Nuclei

An intimate knowledge of aerosol transport is essential in reducing the uncertainty of the impacts of aerosols on cloud development. Data sets from the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement platform in the Southern Great Plains region (ARM‐SGP) and the National Aeronautics and Space Administration (NASA) Modern‐Era Retrospective Analysis for Research and Applications, version 2 (MERRA‐2), showed seasonal increases in aerosol loading and total carbon concentration during the spring and summer months (2008–2016) which was attributed to fire activity and smoke transport within North America. The monthly mean MERRA‐2 surface carbonaceous aerosol mass concentration and ARM‐SGP total carbon products were strongly correlated (R = 0.82, p < 0.01) along with a moderate correlation with the ARM‐SGP cloud condensation nuclei (NCCN) product (0.5, p ~ 0.1). The monthly mean ARM‐SGP total carbon and NCCN products were strongly correlated (0.7, p ~ 0.01). An additional product denoting fire number and coverage taken from the National Interagency Fire Center (NIFC) showed a moderate correlation with the MERRA‐2 carbonaceous product (0.45, p < 0.01) during the 1981–2016 warm season months (March–September). With respect to meteorological conditions, the correlation between the NIFC fire product and MERRA‐2 850‐hPa isobaric height anomalies was lower (0.26, p ~ 0.13) due to the variability in the frequency, intensity, and number of fires in North America. An observed increase in the isobaric height anomaly during the past decade may lead to frequent synoptic ridging and drier conditions with more fires, thereby potentially impacting cloud/precipitation processes and decreasing air quality.
Using Structural Equations to Test a Multi-Theoretical Framework with Data on Cyberstalking Victimization in Iran: Self-Control, Control Deficit, Peers’ Online Deviant Behaviors, and Online Deviant Lifestyles

Although there exists a growing amount of empirical literature documenting the correlates of cyberstalking victimization, research has yet to elaborate on the potential mechanisms that can explain the risk for cyberstalking victimization. We proposed an integrated theory, which combined low self-control, control deficit, peers’ online deviant behavior, and online deviant lifestyles based on previous research. We tested this integrated theory specifically for cyberstalking victimization using original data from a sample of 408 Iranian college women. Relying on structural equation modeling, we found that low self-control and peers’ online deviant behaviors were significantly associated with cyberstalking victimization not only directly but also indirectly via online deviant lifestyles. Overall, our findings yielded strong support for the integrated model to explain cyberstalking victimization.
Negative emotions shape the diffusion of cancer tweets: toward an integrated social network-text analytics approach

PurposeDrawing on the cognitive-functional model of emotions and emotional contagion, the authors aim to examine the role of negative emotions in the diffusion of cancer tweets.Design/methodology/approachUsing an integrated approach of social network and text analytics, the authors analyzed 142,883 cancer tweets from February to March 2018. The roles of negative emotions, emotional contagion, cancer themes and user influence on the diffusion of cancer tweets were examined.FindingsResults indicated that cancer tweets expressing negativity and anger diffused more widely, while those expressing sadness or fear were less likely to diffuse. However, contrary to the authors’ expectation, cancer tweets expressing negative emotions (i.e. negativity, anger and fear) were less likely to arouse similar emotions among retweets, thus suggesting that emotions in cancer tweets were not as contagious as they seemed. Finally, user influence was the most important factor explaining the diffusion of cancer tweets, although cancer-related themes (i.e. affective, informative and social) had marginal effects on likelihood of diffusion.Originality/valueUsing a novel integrated social network–text analytics approach, the authors found that to understand cancer tweets' diffusion, it is critical to go beyond examining the content of tweets about cancer and the influence of messengers – the virality of cancer tweets is inextricable from the negative emotions.
Consumer Credit Card Debt and Immigrants: A Cross-Sectional Study of U.K. Immigrants’ Financial Capability

Purpose: This study examines the ubiquitous nature and high level of consumer debt associated with certain demographics, with a specific focus on immigrants in the U.K. Methodology: A cross-sectional approach was deemed appropriate because the information used for analysis was based on specific points in time for the years 1995, 2000, and 2005. The sample method used was representative of all persons who were resident in Britain at multiple time points consistent to the waves of data collection. The sample used for this analysis was U.K. residents included in the BHPS during the years 1996, 2001, and 2006. Findings: The results showed that individuals with higher levels of education acquired more debt compared to lesser educated people, that credit card debt increased the total consumer debt owed, and that larger households incurred more consumer debt. Unique contribution to theory, practice and policy: The findings from this study may assist in positive social change by providing specific information to banks and lending institutions on how they can manage the credit This study might help in expanding the body of knowledge about the association of credit debt and immigrants in UK, which has received a growing interest among researchers in the field of finance, economics and ethnopolitics. Keywords: Credit debt, Immigrants, Consumer behavior, ethnicity, financial inequality
Quality and Shelf Life of Mango (Mangifera Indica L. cv. `Tainong') Coated by Using Chitosan and Polyphenols

Chitosan-based coatings were used to delay ripening and prolong shelf-life of mango fruit stored at 15±1°C and 85—90% RH for 35 days. Mango fruits were treated with 2% chitosan solution or with 2% chitosan containing 1% tea polyphenols (TP—chitosan). Samples were taken at regular intervals for analysis. Results indicated that chitosan coating alone could decrease the decay incidence and weight loss, and delay the change in colour, pH and titratable acidity of mango fruit during storage. While coating the fruit with TP—chitosan was more effective at keeping quality of the fruit during storage. Firmness of the control fruit declined rapidly to 18.6 N after 5 days of storage at 15°C, which was 22.8% or 71.5% lower than that of the fruit treated with chitosan or TP—chitosan, respectively. Sensory quality of mango was enhanced significantly by the TP—chitosan coating compared with chitosan coating alone. These results suggested that treatment with chitosan containing TP exhibited high potential for shelf-life extension of mango fruit.
Postcranial skeletal development of Mugil cephalus (Teleostei: Mugiliformes): morphological and life-history implications for Mugiliformes

Within the fish taxon Mugiliformes, the larval development of Mugil cephalus has been studied most intensively, because it has the widest range of distribution among all mugilids and is of interest to aquaculture all over the world. Although numerous studies have dealt with larval rearing, growth and development, the osteological development of M. cephalus and mugiliforms in general has largely been neglected. Herein, we describe the skeletal development of mullets for the first time. Cleared and double-stained specimens of aquaculture-reared M. cephalus and wild-caught mugilid larvae were examined to describe the early development of the pectoral and pelvic girdle, the vertebral column and the caudal and median fins. The description of four embryonic and six larval developmental steps within the embryonic and larval period enables us to compare larval sizes of reared and wild-caught larvae. Ontogenetic fusions of ural centra 1 and 2 into a compound centrum, in addition to the fusion of two pterygiophores in the anal fin, have implications for the perception of the adult morphology. Moreover, comparison of mugilid development with that of other ovalentarian taxa shows that recent phylogenetic hypotheses need further morphological investigation.
Commissioned Book Review: Jonathan Fox, Thou Shalt Have No Other Gods before Me: Why Governments Discriminate Against Religious Minorities

‘Thou Shalt Have No Other Gods before Me’ is a very unusual work in its field. Fox has taken the rigour and analytical power of the scientific method and applied it to the field of religious freedom, examining all the available data on government-based religious discrimination (GRD) available for the period 1990 to 2014. This has been carefully processed and distilled, in a compelling intersection of qualitative and quantitative research, to draw some surprising but hard-to-refute conclusions about the nature of religious discrimination as perpetrated by nation-states. It has a wide reaching appeal for practitioners of law and scholars of religion alike, and asks important questions about the place of political actors for those invested in political studies. Fox asks two important questions: what makes a government more likely to discriminate, and why would a government single out a particular minority for discrimination? Unlike the usual conversations on religious freedom, this book gives empirical research which doesn’t exist otherwise for the study of religious freedom, or indeed any kind of fundamental right, particularly from the legal perspective, to answer these questions. This approach (more commonly found in research on economic and social rights for development studies) quantifies, in tangible terms, the seemingly abstract instances of government-based discrimination against religious minorities. It has thrown up some surprising results, and breaks many assumptions about what kinds of states are likely to discriminate against religious minorities. One of the great modern assumptions that Fox tackles is that neoliberal democracies are the most ‘free’ for religious minorities. Fox’s research shows them, however, to be among the worst perpetrators of GRD. In fact, other than Canada, every country examined in this category engages in at least some GRD, particularly against Jewish people and Muslims, and GRD has been increasing constantly in these countries throughout the 24-year period this study covers. This idea of who is most ‘free’ is exacerbated by the general perception existing in the minds of the lay person that Muslimmajority countries are the worst offenders due to their perceived lack of respect for human rights. Fox’s research proves otherwise; though these countries do discriminate, they are not the countries most inclined to commit GRD. But the more interesting finding, and perhaps more shocking for those still studying religion and religious minorities from a white, colonised gaze, is that the very ‘liberalness’ of liberal democracies results in higher GRD. As Fox’s data reveal, secular states will tend to devalue religious ideals per se, and their freedom from discrimination is, in these circumstances, only guaranteed insofar as the religious ideals don’t conflict with the dominant secularist ideology. Thus, Fox tells us:
Hybridization alters growth and migratory life‐history expression of native trout

Human‐mediated hybridization threatens many native species, but the effects of introgressive hybridization on life‐history expression are rarely quantified, especially in vertebrates. We quantified the effects of non‐native rainbow trout admixture on important life‐history traits including growth and partial migration behavior in three populations of westslope cutthroat trout over five years. Rainbow trout admixture was associated with increased summer growth rates in all populations and decreased spring growth rates in two populations with cooler spring temperatures. These results indicate that non‐native admixture may increase growth under warmer conditions, but cutthroat trout have higher growth rates during cooler periods. Non‐native admixture consistently increased expression of migratory behavior, suggesting that there is a genomic basis for life‐history differences between these species. Our results show that effects of interspecific hybridization on fitness traits can be the product of genotype‐by‐environment interactions even when there are minor differences in environmental optima between hybridizing species. These results also indicate that while environmentally mediated traits like growth may play a role in population‐level consequences of admixture, strong genetic influences on migratory life‐history differences between these species likely explains the continued spread of non‐native hybridization at the landscape‐level, despite selection against hybrids at the population‐level.