Miracle-dz/UniFAR-FTUs huggingface dataset:
The DRIFT Dark Matter Project: Directionality, Sensitivity, and Environmental Backgrounds

It is now largely accepted that dark matter, and more specifically, Weakly Interacting Massive Particles (WIMPs), constitute the majority of the mass in our Universe. Within this thesis are presented: (i) an overview of the motivation and evidence for the existence of dark matter; (ii) a detailed discussion of direct detection techniques and a worldwide review of WIMP search experiments; and (iii) new experimental measurements and complementary detailed numerical simulations, carried out by the author, to determine the performance of DRIFT experimental technology. Collectively, this work explores the capability of DRIFT technology to detect dark matter, and in doing so, to resolve one of the key open questions of contemporary science. The DRIFT programme consists of an array of direct dark matter search detectors located in the Boulby mine. An important limitation to the experiment is the neutron and gamma-ray background. Experimental work presented here has determined the U and Th content of the cavern rock to be 66± 6 ppb and 145± 13 ppb respectively, clarifying ambiguities in previous estimations. Through the use of a Monte Carlo simulation the neutron and gamma-ray background experienced by DRIFT has been determined and the experimental implications assessed. In addition, the activity of the main neutron calibration source used to calibrate DRIFT modules has been measured and was found to be 11600 n s−1±5 % on the date of exposure, resolving an earlier discrepancy. Analysis of experimental data has confirmed that the technology employed by DRIFT detectors has the capability to provide directional information of recoiling nuclei at the low energies of interest to dark matter searches. A Monte Carlo simulation has then been employed to determine the WIMP-nucleon sensitivity achievable using DRIFT detectors of the present performance, also examining what would be achievable if this was supplemented by a realistic active neutron veto detector. It is found that a CS2-filled DRIFT type detector running at a 500 NIP threshold (∼16 keV and ∼27 keV for C and S recoils respectively) for 300 kg years, and surrounded by the proposed veto scheme, would expect to observe a background of six un-vetoed events. The minimum positive signal above this background (90 % C.L.) would correspond to a WIMP-nucleon sensitivity limit of ∼1.75× 10−9pb. This identifies the realistic limit of what can be achieved using gaseous CS2 as a target medium. An investigation into the limits achievable using a similar array in which DRIFT modules act as self-vetoing detectors is also examined providing insight into the future development and operation of the DRIFT programme.
Large-Scale Polymorphism Analysis of Dog Leukocyte Antigen Class I and Class II Genes (DLA-88, DLA-12/88L and DLA-DRB1) and Comparison of the Haplotype Diversity between Breeds in Japan

Polymorphisms of canine leukocyte antigen (DLA) class I (DLA-88 and DLA-12/88L) and class II (DLA-DRB1) genes are important for disease susceptibility studies, but information on the genetic diversity among dog breeds is still lacking. To better elucidate the polymorphism and genetic diversity between breeds, we genotyped DLA-88, DLA-12/88L, and DLA-DRB1 loci using 829 dogs of 59 breeds in Japan. Genotyping by Sanger sequencing identified 89, 43, and 61 alleles in DLA-88, DLA-12/88L, and DLA-DRB1 loci, respectively, and a total of 131 DLA-88–DLA-12/88L–DLA-DRB1 haplotypes (88-12/88L-DRB1) were detected more than once. Of the 829 dogs, 198 were homozygotes for one of the 52 different 88-12/88L-DRB1 haplotypes (homozygosity rate: 23.8%). Statistical modeling suggests that 90% of the DLA homozygotes or heterozygotes with one or other of the 52 different 88-12/88L-DRB1 haplotypes within somatic stem cell lines would benefit graft outcome after 88-12/88L-DRB1-matched transplantation. As previously reported for DLA class II haplotypes, the diversity of 88-12/88L-DRB1 haplotypes varied remarkably between breeds but was relatively conserved within most breeds. Therefore, the genetic characteristics of high DLA homozygosity rate and poor DLA diversity within a breed are useful for transplantation therapy, but they may affect biological fitness as homozygosity progresses.
The impact of Cyflumetofen on demographic parameters of two predatory mites, Neoseiulus californicus (M-G) and Phytoseiulus persimilis (A-H)

Abstract The assessment of the long-term negative effects of acaricides on the target and non-target mites can help determine the toxicity and side effects of acaricides. The sublethal concentrations can be very precise and affect populations at concentrations lower than the conventional concentration and may supplement our knowledge about its sublethal effects on the physiology and behavior of insects/mites. Furthermore, we exposed the adults' biocontrol agents mite, Phytoseiulus persimilis Athias-Henriot and Neoseuilus californicus McGregor, to the LC10 and LC30 concentrations of the Cyflumetofen and then assayed the effects of these concentrations on the growth and development of the next generations under laboratory conditions. Analyzed data showed that sublethal concentrations of cyflumetofen significantly affected both species' biological parameters, including the total lifetime, fecundity, and longevity of the treated biocontrol agents compared with the control treatment. Due to our results, when P. persimilis and N. californicus adults were exposed to LC30 concentration of cyflumetofen, the length of the oviposition period of the treated P.persimilis and N. californicus were 20.34 and 19.66 days, respectively. At the same time, these values for the control-treated P. persimilis and N. californicus were 22.51 and 22.21, respectively. The intrinsic rate of increase (r) in control were 0.203 and 0.238, while those treated with LC10 and LC30 of cyflumetofen were estimated to be 0.238 and 0.214 for P. persimilis and 0.203 and 0.223 days–1, for N. californicus, respectively. Therefore, using sublethal concentrations of cyflumetofen is emphasized for designing integrated pest management programs and makes it possible to use biocontrol agents to control the spider mite; thus, it would benefit the farmers and consumers in the long run.
Characteristics of Stress Sensitivity in Heroin Use Disorder Patients during Their Opioid Agonist Treatment

In the present study, performed on a sample of Heroin Use Disorder (HUD) patients undergoing Opioid Agonist Treatment (OAT), we attempted to explore the relationships between stress sensitivity and heroin addiction-related clinical aspects. HUD patients’ stress sensitivity was evaluated with the Heroin/PTSD-Spectrum questionnaire (H/PSTD-S). The Drug Addiction History Questionnaire (DAH-Q), the Symptomatological Check List-90 (SCL-90), and The Behavioural Covariate of Heroin Craving inventory (CRAV-HERO) were all used, as were the Deltito Subjective Wellness Scale (D-SWS), a self-report scale evaluating subjective well-being; the Cocaine Problem Severity Index (CPSI), a questionnaire determining the extent of a cocaine problem; and the Marijuana Craving Questionnaire (MC-Q), an instrument assessing craving for cannabinoids. We checked correlations between stress sensitivity and the extent of HUD clinical features and compared patients with and without problematic stress sensitivity. H/PTSD-S was positively correlated with patients’ income, altered mental status, legal problems, the lifetime different treatments index, the current treatment load index, and all SCL-90 indexes and factors. Regarding subjective well-being, stress sensitivity negatively correlated with the contrast best week (last five years) index. Patients with high-stress sensitivity were females with a low income. They exhibited a more severe mental status at treatment entry, greater difficulty in working adaptation, and legal problems during treatment. Additionally, these patients showed a higher level of psychopathology, more impairment in well-being, and more risky behaviours during treatment. Stress sensitivity, as H/PTSD-S, must be considered an outcome of HUD. HUD’s addiction history and clinical features are significant risk factors for H/PTSD-S. Therefore, social and behavioural impairment in HUD patients could be considered the clinical expression of the H/PTSD spectrum. In summary, the long-term outcome of HUD is not represented by drug-taking behaviours. Rather, the inability to cope with the contingent environmental conditions is the key feature of such a disorder. H/PTSD-S, therefore, should be seen as a syndrome caused by an acquired inability (increased salience) concerning regular (daily) life events.
Differentiation of Spontaneous Bacterial Peritonitis from Secondary Peritonitis in Patients with Liver Cirrhosis: Retrospective Multicentre Study

Ascitic fluid infection is a serious complication of liver cirrhosis. The distinction between the more common spontaneous bacterial peritonitis (SBP) and the less common secondary peritonitis in patients with liver cirrhosis is crucial due to the varying treatment approaches. This retrospective multicentre study was conducted in three German hospitals and analysed 532 SBP episodes and 37 secondary peritonitis episodes. Overall, >30 clinical, microbiological, and laboratory parameters were evaluated to identify key differentiation criteria. Microbiological characteristics in ascites followed by severity of illness and clinicopathological parameters in ascites were the most important predictors identified by a random forest model to distinguish between SBP and secondary peritonitis. To establish a point-score model, a least absolute shrinkage and selection operator (LASSO) regression model selected the ten most promising discriminatory features. By aiming at a sensitivity of 95% either to rule out or rule in SBP episodes, two cut-off scores were defined, dividing patients with infected ascites into a low-risk (score ≥ 45) and high-risk group (score < 25) for secondary peritonitis. Overall, the discrimination of secondary peritonitis from SBP remains challenging. Our univariable analyses, random forest model, and LASSO point score may help clinicians with the crucial differentiation between SBP and secondary peritonitis.
Electron-impact excitation of Ar$^{2+}$

Context. Emission from Ar III is seen in planetary nebulae, in H II regions, and from laboratory plasmas. The analysis of such spectra requires accurate electron impact excitation data. Aims. The aim of this work is to improve the electron impact excitation data available for Ar 2+ , for application in studies of planetary nebulae and laboratory plasma spectra. The effects of the new data on diagnostic line ratios are also studied. Methods. Electron-impact excitation collision strengths have been calculated using the R-Matrix Intermediate-Coupling FrameTransformation method and the R-Matrix Breit-Pauli method. Excitation cross sections are calculated between all levels of the configurations 3s 2 3p 4 ,3 s3p 5 ,3 p 6 ,3 p 5 3d, and 3s 2 3p 3 nl (3d ≤ nl ≤ 5s). Maxwellian effective collision strengths are generated from the collision strength data. Results. Good agreement is found in the collision strengths calculated using the two R-Matrix methods. The collision strengths are compared with literature values for transitions within the 3s 2 3p 4 configuration. The new data has a small effect on Te values obtained from the I(λ7135 A + λ7751 A)/I(λ5192 A) line ratio, and a larger effect on the Ne values obtained from the I(λ7135 A)/I(λ9 μm) line ratio. The final effective collision strength data is archived online � .
PD-1 and PD-L1 Expression Levels as a Potential Biomarker of Chronic Rhinosinusitis and Head and Neck Cancers

Inflammation is an etiological factor of various chronic diseases contributing to more than 50% of worldwide deaths. In this study, we focus on the immunosuppressive role of the programmed death-1 (PD-1) receptor and its ligand (PD-L1) in inflammatory-related diseases, including chronic rhinosinusitis and head and neck cancers. The study included 304 participants. Of this number, 162 patients had chronic rhinosinusitis with nasal polyps (CRSwNP), 40 patients had head and neck cancer (HNC) and there were 102 healthy subjects. The expression level of the PD-1 and PD-L1 genes in the tissues of the study groups was measured by qPCR and Western blot methods. The associations between the age of the patients and the extent of disease and genes’ expression were evaluated. The study showed a significantly higher mRNA expression of PD-1 and PD-L1 in the tissues of both the CRSwNP and HNC patient groups compared to the healthy group. The severity of CRSwNP significantly correlated with the mRNA expression of PD-1 and PD-L1. Similarly, the age of the NHC patients influenced PD-L1 expression. In addition, a significantly higher level of PD-L1 protein was noticed also for both the CRSwNP and HNC patient groups. The increased expression of PD-1 and PD-L1 may be a potential biomarker of inflammatory-related diseases, including chronic rhinosinusitis and head and neck cancers.
Smoothing of substrate pits using ion beam deposition for EUV lithography

Mitigation of pit-type defects proves to be a major hurdle facing the production of a defect-free mask blank for EUV lithography. Recent efforts have been directed toward substrate smoothing methods during deposition. The angle of incidence of the substrate is known to have a significant effect on the growth of defects during deposition. It has been shown that shadowing effects for bump-type defects are reduced when depositing Mo/Si films at near-normal incidence, resulting in a Gaussian growth profile in which the height and volume of the defect are minimized. Conversely, operating at off-normal incidence reduces shadowing of pit-type defects. When altering the angle of incidence of the substrate, the target angle must be changed to maintain uniformity. The resulting mask blank must also meet surface roughness specifications post-deposition while maintaining a low defect density. In this study, various substrate angle and target angle combinations were investigated within the Veeco Nexus Low Defect Density tool at SEMATECH to find optimum in situ pit smoothing conditions using ion beam deposition on both quartz and low thermal expansion material (LTEM) substrates. The possible substrate-target angle combinations are limited by the design of the current deposition tool; therefore, a phase space has been mapped out to determine uniform and non-uniform regions. Other deposition parameters including operating pressure and working gas composition were also explored. After deposition, EUV reflectrometry measurements were taken to evaluate uniformity in the wavelength; surface roughness, change in pit depth, change in full width at half maximum, and pit smoothing power were determined using atomic force microscopy (AFM); transmission electron microscopy (TEM) was used to study the effect of film disruption through the multilayer; and the printability of smoothed pits will be measure actinically using SEMATECH's AIT tool. Preliminary results show that positive values for substrate angles in the uniform region tend to give a high surface roughness after multilayer deposition; however, the combinations with negative substrate angles show promising results. Substrate angles with lower values resulted in better smoothing than the higher substrate angles. AFM results confirmed that pit smoothing power at lower substrate angles is greater than under the standard deposition conditions employed by the tool. Lower chamber pressure was proven to increase the smoothing power of pit-type defects during deposition. Preliminary TEM cross-section data confirmed the smoothing results obtained by AFM analysis. The use of Ne and Xe as working gases is also under review. Extensive AFM analysis, TEM cross-sections, and printability data will be presented.
My Exposed Body: Psychometric Properties of the Italian Version of the Social Physique Anxiety Scale-7 among Women

Background: Social Physique Anxiety (SPA) is the anxiety resulting from the prospect or presence of the interpersonal evaluation of one’s physique. It is a construct related to body image and body esteem. The Social Physique Anxiety Scale-7 (SPAS-7) is a self-report scale aimed at measuring the degree of anxiety that people experience when others evaluate their physique. Methods: This study aimed to investigate the factor structure (through Confirmatory Factor Analysis followed by multi-group confirmatory factorial analyses), reliability, and convergent validity of an Italian version of the SPAS-7 among a sample of women (N = 520; mean age = 33.5, SD = 10.5). Results: Confirmatory Factor Analysis attested the unidimensional factorial structure of the SPAS-7, which achieved full invariance across age groups. The strength of the inter-relationships between the SPAS-7 and measures of negative (i.e., body dissatisfaction) and positive body image (i.e., body appreciation and body compassion) provided evidence of good convergent validity. The Cronbach’s alpha was very good. Conclusion: According to our results, the Italian version of the SPAS-7 could be a valid and agile instrument for assessing self-presentational concerns associated with body image among Italian-speaking women across age.
Effect of Maternal Gradient Nutritional Restriction during Pregnancy on Mammary Gland Development in Offspring

Simple Summary The embryonic period, together with puberty and pregnancy, are known as the three main stages of mammary gland development. The development of the mammary glands is slowed during the embryonic period due to factors such as inadequate nutrition, which directly affect the development of the mammary glands and lactation after birth. However, the impact of embryonic nutrition on fetal mammary gland development is often unnoticed. We investigate the effect of nutritional intake on embryonic mammary gland development by administering different levels of nutritional restriction to female mice during gestation. Contrary to common belief, we found that mild maternal nutritional restriction contributes to mammary gland development in the offspring. Mammary gland dysplasia is not obvious until maternal nutritional restriction reaches 70% of the normal intake. Further embryonic mammary gland development studies can be performed based on our level of maternal nutritional restriction. In addition, the use of mice as model animals can also provide a reference for dairy farming, where nutrition should not be excessive during the gestation period of the cow; otherwise, it affects the mammary gland development of the offspring. Abstract We aimed to investigate the effect of different levels of nutritional restriction on mammary gland development during the embryonic period by gradient nutritional restriction in pregnant female mice. We started the nutritional restriction of 60 female CD-1(ICR) mice from day 9 of gestation based on 100%, 90%, 80%, 70% and 60% of ad libitum intake. After delivery, the weight and body fat of the offspring and the mother were recorded (n = 12). Offspring mammary development and gene expression were explored by whole mount and qPCR. Mammary development patterns of in offspring were constructed using Sholl analysis, principal component analysis (PCA) and regression analysis. We found that: (1) Mild maternal nutritional restriction (90–70% of ad libitum intake) did not affect offspring weight, while body fat percentage was more sensitive to nutritional restriction (lower at 80% ad libitum feeding). (2) A precipitous drop in mammary development and altered developmental patterns occurred when nutritional restriction ranged from 80% to 70% of ad libitum intake. (3) Mild maternal nutritional restriction (90% of ad libitum intake) promoted mammary-development-related gene expression. In conclusion, our results suggest that mild maternal nutritional restriction during gestation contributes to increased embryonic mammary gland development. When maternal nutritional restriction reaches 70% of ad libitum intake, the mammary glands of the offspring show noticeable maldevelopment. Our results help provide a theoretical basis for the effect of maternal nutritional restriction during gestation on offspring mammary development and a reference for the amount of maternal nutritional restriction.
Changes in Bone Metabolism in Patients with Rheumatoid Arthritis during Tumor Necrosis Factor Inhibitor Therapy

Tumor necrosis factor alpha (TNF-α), which enhances osteoclast activity and bone resorption, is one of the key inflammation mediators in rheumatoid arthritis (RA). The aim of this study was to assess the influence of yearlong TNF-α inhibitor application on bone metabolism. The study sample comprised 50 female patients with RA. Analyses involved the osteodensitometry measurements obtained using a “Lunar” type apparatus and the following biochemical markers from serum: procollagen type 1 N-terminal propeptide (P1NP), beta crosslaps C-terminal telopeptide of collagen type I (b-CTX) by ECLIA method, total and ionized calcium, phosphorus, alkaline phosphatase, parathyroid hormone and vitamin D. Analyses revealed changes in bone mineral density (BMD) at L1–L4 and the femoral neck, with the difference in mean BMD (g/cm2) not exceeding the threshold of statistical significance (p = 0.180; p = 0.502). Upon completion of 12-month therapy, a significant increase (p < 0.001) in P1NP was observed relative to b-CTX, with mean total calcium and phosphorus values following a decreasing trend, while vitamin D levels increased. These results suggest that yearlong application of TNF inhibitors has the capacity to positively impact bone metabolism, as indicated by an increase in bone-forming markers and relatively stable BMD (g/cm2).
Effect of Marjoram Leaf Powder Addition on Nutritional, Rheological, Textural, Structural, and Sensorial Properties of Extruded Rice Noodles

Food-to-food fortification is an emerging technique to enrich the micronutrients in foods. Pertaining to this technique, noodles could also be fortified with natural fortificants. In this study, marjoram leaf powder (MLP) at a level of 2–10% was used as a natural fortificant to produce fortified rice noodles (FRNs) through an extrusion process. The MLP addition caused a significant increase in the iron, calcium, protein, and fiber in the FRNs. The noodles had a lower whiteness index than unfortified noodles but had a similar water absorption index. The water solubility index increased significantly due to the higher water retention ability of MLP. A rheological study showed a minimal effect of fortification on the gelling strength of the FRNs at lower levels. The microstructural studies found incremental cracks, which facilitated a lower cooking time and hardness but had an insignificant effect on the cooked noodle texture. Fortification improved the total phenolic content, antioxidant capacity, and total flavonoid content. However, no significant changes in bonds were observed, but a reduction in the noodles’ crystallinity could be seen. The sensory analysis of the noodles reflected a higher acceptability of the 2–4% MLP fortified samples compared to the others. Overall, the MLP addition improved the nutritional content, antioxidant activity, and the cooking time but slightly affected the rheological, textural, and color properties of the noodles.