Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Recurrent Neural Networks for Predicting Type-2 Diabetes from Genomic and Tabular Data

The development of genomic technology for smart diagnosis and therapies for various diseases has lately been the most demanding area for computer-aided diagnostic and treatment research. Exponential breakthroughs in artificial intelligence and machine intelligence technologies could pave the way for identifying challenges afflicting the healthcare industry. Genomics is paving the way for predicting future illnesses, including cancer, Alzheimer’s disease, and diabetes. Machine learning advancements have expedited the pace of biomedical informatics research and inspired new branches of computational biology. Furthermore, knowing gene relationships has resulted in developing more accurate models that can effectively detect patterns in vast volumes of data, making classification models important in various domains. Recurrent Neural Network models have a memory that allows them to quickly remember knowledge from previous cycles and process genetic data. The present work focuses on type 2 diabetes prediction using gene sequences derived from genomic DNA fragments through automated feature selection and feature extraction procedures for matching gene patterns with training data. The suggested model was tested using tabular data to predict type 2 diabetes based on several parameters. The performance of neural networks incorporating Recurrent Neural Network (RNN) components, Long Short-Term Memory (LSTM), and Gated Recurrent Units (GRU) was tested in this research. The model’s efficiency is assessed using the evaluation metrics such as Sensitivity, Specificity, Accuracy, F1-Score, and Mathews Correlation Coefficient (MCC). The suggested technique predicted future illnesses with fair Accuracy. Furthermore, our research showed that the suggested model could be used in real-world scenarios and that input risk variables from an end-user Android application could be kept and evaluated on a secure remote server.
Optimized study of an in vitro 3D culture of preantral follicles in mice

Background In vitro culture of preantral follicles is a promising technology for fertility preservation. Objectives This study aims to investigate an optimized three-dimensional (3D) fetal bovine serum (FBS)-free preantral follicle culture system having a simple and easy operation. Methods The isolated follicles from mouse ovaries were randomly divided in an ultra-low attachment 96-well plates supplement with FBS or bovine serum albumin (BSA) culture or encapsulated with an alginate supplement with FBS or BSA culture. Meanwhile, estradiol (E2) concentration was assessed through enzyme-linked immunosorbent assay of culture supernatants. The diameter of follicular growth was measured, and the lumen of the follicle was photographed. Spindle microtubules of oocytes were detected via immunofluorescence. The ability of oocytes to fertilize was assessed using in vitro fertilization. Results The diameters were larger for the growing secondary follicles cultured in ultra-low attachment 96-well plates than in the alginate gel on days 6, 8, and 10 (p < 0.05). Meanwhile, the E2 concentration in the BSA-supplemented medium was significantly higher in the alginate gel than in the other three groups on days 6 and 8 (p < 0.05), and the oocytes in the FBS-free system could complete meiosis and fertilization in vitro. Conclusions The present study furnishes insights into the mature oocytes obtained from the 3D culture of the preantral follicle by using ultra-low attachment 96-well plate with an FBS-free system in vitro and supports the clinical practices to achieve competent, mature oocytes for in vitro fertilization.
Innovative Technologies in the Neurorehabilitation of Traumatic Brain Injury: A Systematic Review

Motor and cognitive rehabilitation in individuals with traumatic brain injury (TBI) is a growing field of clinical and research interest. In fact, novel rehabilitative approaches allow a very early verticalization and gait training through robotic devices and other innovative tools boosting neuroplasticity, thanks to the high-intensity, repetitive and task-oriented training. In the same way, cognitive rehabilitation is also evolving towards advanced interventions using virtual reality (VR), computer-based approaches, telerehabilitation and neuromodulation devices. This review aimed to systematically investigate the existing evidence concerning the role of innovative technologies in the motor and cognitive neurorehabilitation of TBI patients. We searched and reviewed the studies published in the Cochrane Library, PEDro, PubMed and Scopus between January 2012 and September 2022. After an accurate screening, only 29 papers were included in this review. This systematic review has demonstrated the beneficial role of innovative technologies when applied to cognitive rehabilitation in patients with TBI, while evidence of their effect on motor rehabilitation in this patient population is poor and still controversial.
A phenomenological study of the long-term cosmic ray modulation, 850-1958 AD

[1] The modulation of the galactic cosmic radiation over the past 1150 years is investigated using 10Be data from Greenland and the South Pole. For this purpose, we introduce the use of 22-year averages to study the long-term modulation. After allowance for secular changes in the geomagnetic dipole, it is shown that the 22-year mean intensity of the galactic cosmic radiation (GCR) in the vicinity of 1–2 GeV/nucleon returned to approximately the same high level at the widely separated times of the Oort (1050 AD), Spoerer (1420–1540), and the latter portion of the Maunder (1645–1715) periods of low solar activity. In terms of the modulation potential, ϕ, this asymptotic intensity corresponds to a mean residual modulation of ∼84 MV. The GCR intensity was significantly less during the Wolf (∼1320) and Dalton (1810) minima, and ϕ ∼ 200 MV. The higher temporal resolution data from Greenland shows that there were large 11-year and other fluctuations superimposed upon these high intensities during the Spoerer and Maunder minima (Δϕ ≈ 200–300 MV), indicating the continued presence of a substantial and time-dependent heliomagnetic field. Throughout the Spoerer minimum, the GCR intensity repeatedly returned to a condition of very low modulation, indicating that the cosmic ray spectrum incident on the Earth approached the level of the local interstellar spectrum. These results imply the continued presence of either (or both) (1) the normal cyclic variation of the heliospheric current sheet and/or (2) a cyclic variation of the diffusion coefficients throughout these periods of low solar activity. The data indicate that the modulation (i.e., depression) of the cosmic ray intensity during the instrumental era (1933–present) has been one of the greatest in the past 1150 years. Further, approximately the same low value has been attained on five previous widely separated occasions since 850 AD, and we speculate that the heliospheric magnetic field has reached an asymptotic limit at those times. The 10Be data exhibit a previously unrecognized feature, which we have named “the precipitous decrease,” in which the 1–2 GeV/nucleon intensity decreased by ∼40–45% between 1700 and 1739 corresponding to Δϕ > 500 MV, at a time of low but increasing solar activity. A lower cosmic ray intensity than that attained in 1739 was not observed again until after 1950, at a time of high solar activity. These features and the large 11-year modulation events during the Spoerer and Maunder minima indicate that the long-term variations in the GCR intensity are poorly related to sunspot number during epochs of low solar activity. It is shown that there is better agreement between the variations in the 10Be data, and the changes in the open solar magnetic flux predicted by the Schrijver et al. [2002] and Solanki et al. [2002] models based on historic sunspot numbers. In particular, they both exhibit characteristics consistent with the precipitous decrease in the 10Be data, although the amplitudes are smaller than implied by the 10Be data.
Environmental Impacts of Energy Usage in Selected Tea Factories in Kenya

Objective: To assess the environmental impacts of various energy uses in Kenya tea factories to establish possible combinations for climate change mitigation. Tea industry provides livelihood for approximately 10% of the country’s total population but consumes considerable amount of energy during tea production and processing. The use of different energy sources in tea factories during processing causes different environmental impacts, which necessitates the search for environmentally friendly and sustainable energy source(s) through comparison of the environmental impacts of different energy sources. Few studies have assessed the combination of different energy use in tea factories or the use of modelling tools to explore environmental impacts. To this end, this paper assesses the environmental impacts of different energy usage by four tea factories in Kenya for a period of 5 years. Methods: The study used the life circle assessment (LCA) method for comparative evaluation of environmental impacts of electricity, biogas, solar, firewood and briquettes as the source of energy. Simapro 7.1 software was used for the analysis of the LCA with Eco-indicator 99 as the assessment method. The problem-oriented and damage-oriented impact categories of ReCiPe 2016 global scale
Immune Ablation and Stem Cell Rescue in Two Pediatric Patients with Progressive Severe Chronic Graft-Versus-Host Disease

Transplantation of allogeneic hematopoietic stem cells represents an established treatment for children with high-risk leukemia. However, steroid-refractory chronic graft-versus-host disease (SR-cGvHD) represents a severe life-threatening complication, for which there is no standard therapy. After failing several lines of immunosuppressive and biological treatment, we applied an immunoablative therapy with re-transplantation of purified CD34+ donor stem cells to reset the aberrant immune system. Two pediatric patients, who had been transplanted for high-risk acute lymphoblastic leukemia, underwent the procedure. Interestingly, enough stem cells could be mobilized, harvested, and purified to be used as grafts more than one year after allogeneic transplantation under intensive immunosuppressive therapy and ongoing SR-cGvHD. With a follow-up of 8 and 22 months, respectively, both patients are without immunosuppressive therapy and do not show signs of active disease. Regeneration of skin manifestations started promptly, other damaged organs did not progress and continue to show recovery from severe fibrotic transformation. Bone marrow function is robust and T cell receptor repertoires showed polyclonal immune reconstitution. In conclusion, stem cell harvest and re-transplantation of human CD34+-selected allogeneic stem cells is possible and represents a new therapeutic option in SR-cGvHD by resetting a profoundly disturbed immune network.
Evaluation of Selected Oxidant/Antioxidant Parameters in Patients with Relapsing-Remitting Multiple Sclerosis Undergoing Disease-Modifying Therapies

The aim of this study was to evaluate oxidative stress parameters, specifically the concentration of advanced oxidation protein products (AOPP) and ferric-reducing antioxidant power (FRAP), in the serum of patients with relapsing-remitting multiple sclerosis (RRMS). We also analyzed the relationships between each parameter and selected clinical/laboratory multiple-sclerosis-related parameters. The study group comprised 204 patients with RRMS and 29 healthy, age-matched controls. The concentration of AOPP was significantly higher in the RRMS patients than in controls. ROC analysis showed the ability of AOPP to distinguish between the patients with RRMS and controls (the value of AUC was 94.8%, with a sensitivity of 89.69% and specificity of 89.3%). AOPP and FRAP were significantly higher in male than in female RRMS patients. Correlations were found between AOPP and the laboratory markers of inflammation. AOPP differed in the subgroups of patients treated with particular medications. Our findings indicate an increase in the markers of oxidative stress in the serum of RRMS patients, possibly linked with chronic inflammation. Gender and type of treatment affected the markers of oxidative stress.
Emergency Braking Evoked Brain Activities during Distracted Driving

Electroencephalogram (EEG) was used to analyze the mechanisms and differences in brain neural activity of drivers in visual, auditory, and cognitive distracted vs. normal driving emergency braking conditions. A pedestrian intrusion emergency braking stimulus module and three distraction subtasks were designed in a simulated experiment, and 30 subjects participated in the study. The common activated brain regions during emergency braking in different distracted driving states included the inferior temporal gyrus, associated with visual information processing and attention; the left dorsolateral superior frontal gyrus, related to cognitive decision-making; and the postcentral gyrus, supplementary motor area, and paracentral lobule associated with motor control and coordination. When performing emergency braking under different driving distraction states, the brain regions were activated in accordance with the need to process the specific distraction task. Furthermore, the extent and degree of activation of cognitive function-related prefrontal regions increased accordingly with the increasing task complexity. All distractions caused a lag in emergency braking reaction time, with 107.22, 67.15, and 126.38 ms for visual, auditory, and cognitive distractions, respectively. Auditory distraction had the least effect and cognitive distraction the greatest effect on the lag.
The Role of the Gut Microbiome in Pediatric Obesity and Bariatric Surgery

Obesity affects 42.4% of adults and 19.3% of children in the United States. Childhood obesity drives many comorbidities including hypertension, fatty liver disease, and type 2 diabetes mellitus. Prior research suggests that aberrant compositional development of the gut microbiome, with low-grade inflammation, precedes being overweight. Therefore, childhood may provide opportunities for interventions that shape the microbiome to mitigate obesity-related diseases. Children with obesity have gut microbiota compositional and functional differences, including increased proinflammatory bacterial taxa, compared to lean controls. Restoration of the gut microbiota to a healthy state may ameliorate conditions associated with obesity and help maintain a healthy weight. Pediatric bariatric (weight-loss) surgery is an effective treatment for childhood obesity; however, there is limited research into the role of the gut microbiome after weight-loss surgery in children. This review will discuss the magnitude of childhood obesity, the importance of the developing microbiome in establishing metabolic pathways, interventions such as bariatric surgery that may modulate the gut microbiome, and future directions for the potential development of microbiome-based therapeutics to treat obesity.
Towards the development of a fire retardant sugar-cane bagasse ply for composite manufacture: A flammability study

This study investigated suspending two fire retardants in sugar-cane bagasse plies used for manufacturing natural fibre reinforced composites. Sugar-cane bagasse was alkali treated, blended with either APP (Ammonium Polyphosphate) or ATH (Aluminium Hydroxide), pressed and dried to form plies. Composites were manufactured using a light resin transfer moulding process with epoxy resin. Composites manufactured with fire retardant suspended plies were compared to composites with plies layered with equivalent amounts of fire retardants. The composites were characterised using thermogravimetric analysis (TGA) for thermal stability and char yield, isotropic hot disc method for thermal properties, and cone calorimeter for studying ignition and flammability. Plies suspended with APP had the highest char yield of 58% (in nitrogen), reducing to 26% in the composite form, with degradation driven by the epoxy matrix. The composite layered with ATH had the latest ignition times of 118 s when tested with a radiant heat flux of 35 kW/m2. The composite layered with APP displayed the lowest average heat release rate (179.7k W/m2), peak heat release rate (305.6k W/m2), and total heat released (135.5 MJ/kg). When assessing the fire growth, the composite layered with APP was again favourable. While the layering yielded more favourable results than the suspension of the same retardants, this study showed that a rudimentary process was able to suspend enough retardants to improve the behaviour of the resulting composites in a fire scenario.
Energy integral method model for the nonlinear dynamics of an axisymmetric thin liquid film falling on a vertical cylinder

The nonlinear dynamics of an axisymmetric liquid film falling on the outer surface of a vertical cylinder is investigated in this paper. Using the energy integral method we derive a set of two coupled evolution equations which constitute a first-order approximation to the original hydrodynamic equations. We carry out the linear stability analysis of the axially uniform axisymmetric flow of a liquid film in the framework of the evolution equations. The results of the linear theory are compared to experimental results and with several other relevant linear stability theories available in literature. Traveling wave solutions of the evolution equations are investigated and favorably compared to experiments and other nonlinear theories describing the dynamics of falling films on a vertical cylinder. A bifurcation structure of traveling wave flows is studied for the cases of fluids with both low and relatively large Kapitza number. Both γ1- and γ2-waves are found and investigated.
Patient‐reported outcomes associated with reflex BRCA1/2 tumor and subsequent germline panel genetic testing for high‐grade serous ovarian cancer

Reflex genetic testing of tumor tissue is being completed to direct cancer treatment; however, the patient impact of this genetic testing model is unknown. This survey study evaluates psychological outcomes following tumor and germline genetic testing in individuals with a new diagnosis of high‐grade serous ovarian cancer (HGSOC). Individuals were recruited from two hospitals in Toronto, Canada. Participants completed surveys 1 week after receiving tumor results and 1 week after receiving germline results (which included genetic counseling). Outcomes included cancer‐related distress (Impact of Events Scale: IES), genetic testing‐related distress (Multidimensional Impact of Cancer Risk Assessment: MICRA), and patient satisfaction. Paired t‐tests were used to evaluate differences in outcomes following each genetic test result; Cohen's d was used to evaluate effect size. Subgroup analyses were undertaken according to age at diagnosis (<60 years vs. ≥60 years) and test results (any positive vs. both negative). McNemar's test assessed differences in satisfaction. Fifty‐two individuals were included in the analyses. Mean IES scores were similar following disclosure of tumor and germline results (27.39 vs. 26.14; p = 0.481; d = 0.101). Compared to following tumor result disclosure, MICRA scores were significantly lower following receipt of germline results with genetic counseling (27.23 vs. 22.69; p = 0.007; d = 0.435). Decreases in MICRA scores from tumor to germline result disclosure were greater for those diagnosed <60 years or those who received only negative test results. Most individuals were satisfied/highly satisfied following tumor (85.7%) and germline (89.8%) results disclosure (p = 0.774). Reflex tumor, and subsequent germline, genetic testing is a new model of care for cancer patients. In our cohort, genetic testing‐related distress decreased significantly following receipt of germline results with genetic counseling, especially for individuals diagnosed under 60 years and those receiving only negative results. Most individuals were satisfied with this model of care.
Status and Trends in the Rate of Introduction of Marine Non-Indigenous Species in European Seas

Invasive alien species are a major worldwide driver of biodiversity change. The current study lists verified records of non-indigenous species (NIS) in European marine waters until 2020, with the purpose of establishing a baseline, assessing trends, and discussing appropriate threshold values for good environmental status (GES) according to the relevant European legislation. All NIS records were verified by national experts and trends are presented in six-year assessment periods from 1970 to 2020 according to the European Union Marine Strategy Framework Directive. Altogether, 874 NIS have been introduced to European marine waters until 2020 with the Mediterranean Sea and North-East Atlantic Ocean hosting most of the introductions. Overall, the number of new introductions has steadily increased since 2000. The annual rate of new introductions reached 21 new NIS in European seas within the last six-year assessment period (2012–2017). This increase is likely due to increased human activities and research efforts that have intensified during the early 21st century within European Seas. As Europe seas are not environmentally, nor geographically homogenous, the setting of threshold values for assessing GES requires regional expertise. Further, once management measures are operational, pathway-specific threshold values would enable assessing the effectiveness of such measures.
A STUDY ON DYNAMIC RELATIONSHIP BETWEEN GOLD PRICE AND STOCK MARKET PRICE IN INDIA

Gold has always been contemplate an attractive investment in India and its excellent performance in recent years has substantially confirmed the wisdom of that tradition. When markets are volatile the investors are into panic and so they tend to move out the risky assets they have invested such as stock and invest into assets such as gold. The main objective of the paper is to analyse the effect of Gold prices on Indian stock market represented by Nifty-50. This study is based on the secondary data collected which investigates the homogeneity between Gold price and Stock market price (Nifty) by using daily time series data from January 2018 to May 2021.
Locked down or locked out? Trends in psychiatric emergency services utilization during the COVID-19 pandemic

Objective To estimate changes in Boston Emergency Services Team (BEST) psychiatric emergency services (PES) encounter volume (total and by care team) and inpatient disposition during the first 8 months of the COVID-19 pandemic. Methods Data on 30,657 PES encounters was extracted from the four-county, BEST reporting system. The study period consisted of the first 34 weeks of 2019 and 2020. This period corresponded to the first five stages of Massachusetts’s COVID-19 public health restrictions: pre-lockdown, lockdown, Phase I, II and III reopenings. Descriptive and regression analyses were performed to estimate changes in encounter volume by care team and disposition. Results Compared to the same period in 2019, covariate-adjusted, weekly PES encounters decreased by 39% (β = −0.40, 95% Confidence Interval (CI) = [−0.51, −0.28], p < 0.00) during the lockdown. PES volume remained significantly lower during Phase I reopening compared to the previous year but returned to 2019 levels during Phase II. The covariate-adjusted proportion of weekly encounters that led to inpatient admission significantly increased by 16% (CI = [0.11, 0.21], p < 0.00) for mobile crisis teams (MCTs) and significantly declined by 13% (CI = [−0.19, −0.07], p < 0.00) for BEST-designated emergency departments during the lockdown period compared to the prior year. Conclusions The overall drop in PES utilization and the rise in inpatient admissions for MCT encounters suggests that during the early phases of the pandemic, patients delayed psychiatric care until they had a psychiatric crisis. Public health messaging about the lockdowns and absent equivalent messaging about the availability of telehealth services may have made patients more reluctant to seek psychiatric care.