Miracle-dz/UniFAR-FTUs huggingface dataset:
Technological Independence in Chinese-Western Philosophies of Technology

This project aims to examine the theory of technological independence in Chinese-Western philosophies of technology. This paper argues for technological independence by debating whether technology and science represent two separate fields. It then proposes a technological independence program. Technological independence manifesto has distinct significance for technological education, research, and policy. Technological independence road mapping provides a means by which future-oriented technology analysis is applied to education, research, and policy. Technological independence road mapping can, and should, dynamically interact with and learn from other areas, including science, to achieve effective integrations in the social market. This process of development is measured by comparative data analysis and managed by a series of strategies in the inputs, outputs, outcomes, and impacts. Technological independence road mapping benefits technological education, research in the philosophy of technology and the history of technology, and technological policy. However, humans are ultimately responsible for the technologies they develop.
Conventional versus Digital Impressions for Full Arch Screw-Retained Maxillary Rehabilitations: A Randomized Clinical Trial

Background: The objective of this study was to compare conventional versus digital impressions for Full-Arch maxillary rehabilitations. Methods: Patients selected for this study were treated with full-arch screw-retained rehabilitations supported by six immediately loaded dental implants. Patients have been scheduled randomly into control (conventional impression group, CIG) and test (digital impression group, DIG) groups respectively for a fully conventional workflow and a fully digital workflow. In both groups, within 24 h, temporary prostheses were delivered. Four months after the implant positioning, the two groups dealt with the fabrication of definitive restorations: conventional pick-up was performed in the control group, and definitive digital impressions were carried out in the test group. The time involved following these two procedures was recorded. Patients underwent intraoral digital radiographs to evaluate the accuracy of the framework-implant connection, check for the presence of voids at the bar-implant connection and measure bone level. Criteria used to assess success at the prosthetic level were the occurrence of prosthetic maintenance, the absence of fractures of the acrylic resin superstructure and voids. Results: A total of 50 patients received immediately loaded prostheses supported by six implants (total 300 implants). A fixture and prosthetic survival rate of 100% was observed. All digital X-ray examinations revealed a bar-implant connection accuracy and no voids. Differences that were not statistically significant (p > 0.05) in marginal bone loss were found between control and test groups. Significantly less time was spent to perform digital impression procedure (p < 0.05). Conclusions: Clinical and radiological results of the test group advocate a satisfactory accuracy and predictability of the intraoral scanner (IOS) to be a reliable alternative in clinical practice for implant full-arch rehabilitations and suggest fabrication of definitive restorations with a successful marginal fit precision.
FDI, Firm Heterogeneity and Exports An analysis of Indian Manufacturing

Using firm-level data, this paper investigates whether Foreign Direct Investment (FDI), and hence Multinational Enterprise (MNE) presence, explains India’s improved export performance during post-reforms. The recent literature stresses that firm heterogeneity gives some firms an edge over others to self select into export market. Apart from ownership, this paper takes into account firm heterogeneity and various other firm-specific factors while understanding firm-level export performance. Hausman-Taylor estimation results show that foreign ownership does not have significantly different impact on export performance over domestic firms across sectors in Indian manufacturing. Rather firms acquire internationally competitiveness from imported raw materials, foreign technical know-how and local R&D. Further, firm heterogeneity measured in terms of sunk costs significantly impacts on firm-level export intensity. The study further reveals that there are ownership specific factors that determine firm-level exports. The results have significant implications for policy in order to attain international competitiveness of firms in India.
Depression, Anxiety and Stress Scales (DASS-21): Construct Validity Problem in Hispanics

The main purpose of this research was to examine the construct validity of the Depression, Anxiety and Stress Scales (DASS-21) in order to determine whether it is able to adequately discriminate between symptoms of depression and anxiety in the Hispanic population in Puerto Rico. This study has an instrumental design. A total of 1073 Hispanics participated in this psychometric study. The results showed that the DASS-21 has serious psychometric deficiencies, especially related to the construct validity, as well as convergent and discriminatory validity. In addition, it was shown that DASS-21 do not replicate the three-dimensional structure of the original instrument in the Hispanic community. Finally, it was confirmed that the DASS-21 have difficulty in properly identifying and discriminating between symptoms associated with depression and anxiety in a Hispanic population.
Organizational Structure as a Predictor of Employee Involvement and Quality of Production: Evidence for Malaysia Manufacturing Firms

Organizational structure provides guidance to all employees by laying out the official reporting relationships that govern the work flow of the organization. This study tries to open up many windows, still locked in the area of organizational structure in regards to employee involvement and quality of production in manufacturing industry in Malaysia. Such information would enhance the school of thought among researchers.
Unique associations of eudaimonic and hedonic wellbeing with psychosocial adjustment in breast cancer survivors

Abstract Purpose: Eudaimonic wellbeing (e.g., meaning, purpose in life) and hedonic wellbeing (e.g., happiness, life satisfaction) are related but conceptually distinct facets of wellbeing. Eudaimonic wellbeing is highly underexplored in cancer research despite its relevance to important existential concerns faced by cancer survivors. Therefore, this study examined the unique associations of eudaimonic and hedonic wellbeing with adjustment in breast cancer survivors. Methods: Women diagnosed with early-stage breast cancer within two years (N = 64) were recruited through the UCLA Tumor Registry and completed self-report questionnaires (Mental Health Continuum – Short Form Scale, Posttraumatic Growth Inventory, Social Provisions Scale, Quality of Life in Adult Cancer Survivors Scale, Center for Epidemiological Studies – Depression Scale, Pittsburgh Sleep Quality Index, Fatigue Symptom Inventory, Perceived Stress Scale). Findings: Controlling for their shared variance and covariates, eudaimonic wellbeing was uniquely associated with greater posttraumatic growth (β = 0.42, p = .026, R2 = .07), more reliable social support (β = 0.50, p = .010, R2 = .09), and marginally lower fear of recurrence (β = –0.40, p = .063, R2 = .06) while hedonic wellbeing was uniquely associated with lower sleep disturbance (β = –0.56, p = .004, R2 = .12), fatigue (β = –0.53, p = .003, R2 = .11), and depressive symptoms (β = –0.59, p < .001, R2 = .14). Conclusions: Findings suggest eudaimonic wellbeing may confer quality of life benefits beyond symptom reduction in breast cancer survivors, while hedonic wellbeing is primarily associated with fewer behavioral symptoms.
Highly fluorinated erbium(III) complexes for emission in the C-band

Two highly fluorinated Er complexes with three 6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5octanedionate (fod) groups and either bipyridine (bipy) or bathophenantholine (bath) as the ancillary ligand emitting at the C-band (third communication window for fiber transmission) are presented. These complexes are the result of a design process aimed at decreasing the vibrational quenching from high frequency oscillators. The structure of [Er(fod)3(bipy)] has been elucidated by single-crystal X-ray diffraction, while Sparkle/PM6 and Sparkle/PM7 semi-empirical calculations have been used to model the ground state geometry for [Er(fod)3(bath)]. Photoluminescence studies confirm sensitization of the Er ions by antenna effect, leading to NIR emission at 1.53 μm. This energy transfer proves to be more efficient for [Er(fod)3(bath)] as a result of the bulkier and more rigid structure of bath diimide. The good thermal stability of the materials up to over 200 oC allows envisaging their use in erbium-doped waveguides, NIR-OLEDs or other optoelectronic devices.
On Differential Equations Characterizing Legendrian Submanifolds of Sasakian Space Forms

In this paper, we give an estimate of the first eigenvalue of the Laplace operator on minimally immersed Legendrian submanifold N n in Sasakian space forms N ˜ 2 n + 1 ( ϵ ) . We prove that a minimal Legendrian submanifolds in a Sasakian space form is isometric to a standard sphere S n if the Ricci curvature satisfies an extrinsic condition which includes a gradient of a function, the constant holomorphic sectional curvature of the ambient space and a dimension of N n . We also obtain a Simons-type inequality for the same ambient space forms N ˜ 2 n + 1 ( ϵ ) .
Connective auxin transport contributes to strigolactone-mediated shoot branching control independent of the transcription factor BRC1

The shoot systems of plants are built by the action of the primary shoot apical meristem, established during embryogenesis. In the axil of each leaf produced by the primary meristem, secondary axillary shoot apical meristems are established. The dynamic regulation of the activity of these axillary meristems gives shoot systems their extraordinary plasticity of form. The ability of plants to activate or repress these axillary meristems appropriately requires communication between meristems that is environmentally sensitive. The transport network of the plant hormone auxin has long been implicated as a central player in this tuneable communication system, with other systemically mobile hormones, such as strigolactone and cytokinin, acting in part by modulating auxin transport. Until recently, the polar auxin transport stream, which provides a high conductance auxin transport route down stems dominated by the auxin export protein PIN-FORMED1 (PIN1), has been the focus for understanding long range auxin transport in the shoot. However, recently additional auxin exporters with important roles in the shoot have been identified, including PIN3, PIN4 and PIN7. These proteins contribute to a wider less polar stem auxin transport regime, which we have termed connective auxin transport (CAT), because of its role in communication across the shoot system. Here we present a genetic analysis of the role of CAT in shoot branching. We demonstrate that in Arabidopsis, CAT plays an important role in strigolactone-mediated shoot branching control, with the triple pin3pin4pin7 mutant able to suppress partially the highly branched phenotype of strigolactone deficient mutants. In contrast, the branchy phenotype of mutants lacking the axillary meristem-expressed transcription factor, BRANCHED1 (BRC1) is unaffected by pin3pin4pin7. We further demonstrate that mutation in the ABCB19 auxin export protein, which like PIN3 PIN4 and PIN7 is widely expressed in stems, has very different effects, implicating ABCB19 in auxin loading at axillary bud apices.
Distinct metabolic patterns during microglial remodeling by oleate and palmitate

Microglial activation by oleate and palmitate differentially modulates brain inflammatory status. However, the metabolic reprogramming supporting these reactive phenotypes remains unknown. Employing real-time metabolic measurements and lipidomic analysis, we show that both fatty acids promote microglial oxidative metabolism, while lipopolysaccharide (LPS) enhances glycolytic rates. Interestingly, oleate treatment was followed by enrichment in storage lipids bound to polyunsaturated fatty acids (PUFA), in parallel with protection against oxidative imbalance. Palmitate, in turn, induced a distinct lipid distribution defined by PUFA linked to membrane phospholipids, which are more susceptible to lipid peroxidation and inflammatory signaling cascades. This distribution was mirrored by LPS treatment, which led to a strong pro-inflammatory phenotype in microglia. Thus, although both oleate and palmitate preserve mitochondrial function, a contrasting lipid distribution supports differences in fatty acid-induced neuroinflammation. These data reinforce the concept that reactive microglial profiles are achieved by stimulus-evoked remodeling in cell metabolism.
Pretreatment Fasting Glucose and Insulin as Determinants of Weight Loss on Diets Varying in Macronutrients and Dietary Fibers—The POUNDS LOST Study

Efforts to identify a preferable diet for weight management based on macronutrient composition have largely failed, but recent evidence suggests that satiety effects of carbohydrates may depend on the individual’s insulin-mediated cellular glucose uptake. Therefore, using data from the POUNDS LOST trial, pre-treatment fasting plasma glucose (FPG), fasting insulin (FI), and homeostatic model assessment of insulin resistance (HOMA-IR) were studied as prognostic markers of long-term weight loss in four diets differing in carbohydrate, fat, and protein content, while assessing the role of dietary fiber intake. Subjects with FPG <100 mg/dL lost 2.6 (95% CI 0.9;4.4, p = 0.003) kg more on the low-fat/high-protein (n = 132) compared to the low-fat/average-protein diet (n = 136). Subjects with HOMA-IR ≥4 lost 3.6 (95% CI 0.2;7.1, p = 0.038) kg more body weight on the high-fat/high-protein (n = 35) compared to high-fat/average-protein diet (n = 33). Regardless of the randomized diet, subjects with prediabetes and FI below the median lost 5.6 kg (95% CI 0.6;10.6, p = 0.030) more when consuming ≥35 g (n = 15) compared to <35 g dietary fiber/10 MJ (n = 16). Overall, subjects with normal glycemia lost most on the low-fat/high-protein diet, subjects with high HOMA-IR lost most on the high-fat/high protein diet, and subjects with prediabetes and low FI had particular benefit from dietary fiber in the diet.
The Thalamus Regulates Retinoic Acid Signaling and Development of Parvalbumin Interneurons in Postnatal Mouse Prefrontal Cortex

Visual Abstract Abstract GABAergic inhibitory neurons in the prefrontal cortex (PFC) play crucial roles in higher cognitive functions. Despite the link between aberrant development of PFC interneurons and a number of psychiatric disorders, mechanisms underlying the development of these neurons are poorly understood. Here we show that the retinoic acid (RA)-degrading enzyme CYP26B1 (cytochrome P450 family 26, subfamily B, member 1) is transiently expressed in the mouse frontal cortex during postnatal development, and that medial ganglionic eminence (MGE)-derived interneurons, particularly in parvalbumin (PV)-expressing neurons, are the main cell type that has active RA signaling during this period. We found that frontal cortex-specific Cyp26b1 knock-out mice had an increased density of PV-expressing, but not somatostatin-expressing, interneurons in medial PFC, indicating a novel role of RA signaling in controlling PV neuron development. The initiation of Cyp26b1 expression in neonatal PFC coincides with the establishment of connections between the thalamus and the PFC. We found that these connections are required for the postnatal expression of Cyp26b1 in medial PFC. In addition to this region-specific role in postnatal PFC that regulates RA signaling and PV neuron development, the thalamocortical connectivity had an earlier role in controlling radial dispersion of MGE-derived interneurons throughout embryonic neocortex. In summary, our results suggest that the thalamus plays multiple, temporally separate roles in interneuron development in the PFC.
Site preference and tetragonal distortion in palladium-rich Heusler alloys

Two kinds of competition between different Heusler structure types are explored. The first is the competition between XA and L21 structures based on the cubic system of full-Heusler alloys of Pd2 YZ and the second is the competitive mechanism between the L21 cubic system and its L10 tetragonal system.
Investigating the Stability Difference between Current Operating Accruals and Cash Items and Net Return on Assets in Future Period

Previous studies have provided evidences that, higher accrual profitability obligation in comparison with accrual profitability in each period is associated with lower profitability performance in future periods. These findings were interpreted as an increase in operating accruals adversely affect operating profit in future periods, thus decreasing the profitability of coming period. In this study, we demonstrated that, accrual profitability has no adverse effect on the operating profitability of the next period and lower stability of current accrual profitability to cash profitability in relation with operating profit of the next period lies beneath the stronger correlation between current accrual profitability and cash profitability with net operating assets. [Ayyub Ahmadi, Mojtaba Afsordeh. Investigating the Stability Difference between Current Operating Accruals and Cash Items and Net Return on Assets in Future Period. Life Sci J 2012;9(2s):1-7] (ISSN:1097-8135). http://www.lifesciencesite. com. 1
Ridge alterations after implant placement in fresh extraction sockets or in healed crests: An experimental in vivo investigation

OBJECTIVES To study the early and late bone healing around implants placed according to a flapless immediate (test) or flapped delayed (control) implant surgical protocol. MATERIALS AND METHODS In eight beagle dogs, immediate and delayed implants were placed. Test and control implants were randomly assigned, and horizontal and vertical bone remodelling, as well as bone-to-implant contact (BIC), were assessed with histology at 2 and 8 weeks. Teeth were used as negative controls. RESULTS Similar results were attained in the two groups when the vertical resorption of the buccal bone crest was evaluated (approximately 0.5 mm). On the other hand, a marked horizontal buccal bone resorption was observed. Immediate implants attained a thinner buccal bone crest as compared to the delayed implant and the tooth. De novo bone formation on the implant surface appeared to be more pronounced at delayed sites at 2 weeks, whereas at 8 weeks, no difference in BIC was observed. CONCLUSIONS Ridge alterations occurred at both implant placement protocols, with similar limited amounts of vertical buccal bone reduction and a pronounced horizontal bone reduction. The process of horizontal bone remodelling differed between the two surgical protocols.
Resistance to lysosomotropic drugs used to treat kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5

Lysosomotropic agents such as sunitinib, lapatinib, and chloroquine belong to a drug family that is being used more frequently to treat advanced cancers. Sunitinib is standard care for metastatic renal cell carcinomas (mRCC) and lapatinib is used for trastuzumab/pertuzumab-refractory cancers. However, patients ineluctably relapse with a delay varying from a few months to a few years. To improve reactivity prior to relapse it is essential to identify the mechanisms leading to such variability. We showed previously that sunitinib became sequestered in lysosomes because of its basic pKa. Methods: Modifications to gene expression in response to sunitinib and in sunitinib resistant cells were analyzed by transcriptomic and proteomic analysis. ROS production was evaluated by FACS. Nuclear Factor kappa B (NFkB)-dependent transcriptional regulation of inflammatory gene expression was evaluated with a reporter gene. Correlation of CXCL5 with survival was analyzed with an online available data base (TCGA) and using a cohort of patients enrolled in the SUVEGIL clinical trial (NCT00943839). Results: We now show that sunitinib sequestration in lysosomes induced an incomplete autophagic process leading to activation of the NFkB inflammatory pathway. We defined a subset of inflammatory cytokines that were up-regulated by the drug either after an acute or chronic stimulus. One of the most up-regulated genes in sunitinib-resistant cells was the CXCL5 cytokine. CXCL5 was also induced in RCC by chloroquine and in a model of HER2 positive breast cancer cell lines after acute or chronic treatment with lapatinib. CXCL5 correlated to shorter survival in RCC and to the most aggressive forms of breast cancers. The levels of CXCL5 present in the plasma of patients treated with sunitinib were predictive of the efficacy of sunitinib but not of the VEGF-directed antibody bevacizumab. Conclusion: This translational study identified CXCL5 as a biomarker of efficacy of lysosomotropic drugs, a potential asset for personalized medicine.
Acute Effect of Repeated Sprints on Interlimb Asymmetries During Unilateral Jumping

Abstract Bishop, C, McAuley, W, Read, P, Gonzalo-Skok, O, Lake, J, and Turner, A. Acute effect of repeated sprints on interlimb asymmetries during unilateral jumping. J Strength Cond Res 35(8): 2127–2132, 2021—The aim of this study was to investigate the effects of multiple repeated sprints on unilateral jump performance and interlimb asymmetries. Eighteen recreationally active men performed 3 single-leg countermovement jumps (SLCMJ) as baseline data. The repeated sprint protocol was 6 × 40 m with 20 seconds of passive rest between each sprint. This protocol was conducted 4 times, each set separated by 4 minutes of rest. Within that rest period, subjects performed one SLCMJ on each limb after 2 minutes of rest. A 1-way analysis of variance showed significant reductions (p < 0.05; effect size [ES] = −0.52 to −0.99) in jump height on both limbs after each set relative to baseline. Interlimb asymmetries increased at each time point and ranged from 7.62 to 14.67%, with significant increases in asymmetry seen after sets 3 (p = 0.046) and 4 (p = 0.002). Significant increases in sprint time were shown between sprints 1 and 6 in each set (p ≤ 0.01). A fatigue index (%) was also calculated and showed an exponential increase from 5.74% (set 1) to 13.50% (set 4), with significant differences between all sets (p < 0.001) with the exception of sets 3 and 4. Results from this study show that a 6 × 40-m repeated sprint protocol is a sufficient dose for implementing acute fatigue in recreationally active subjects. This was manifested by reductions in jump height at all time points and jump height asymmetries after the third and fourth sets. These findings indicate that jump height from unilateral jump testing may be a useful metric to use during the monitoring process in recreationally trained athletes.
Normalized localization for 6-DOF camera pose regression

Visual localization determines the position of the viewer in a scene based on his or her viewpoint picture. The problem is challenging because we must handle various view-points in addition to picture quality. In this paper, we present a model that regresses the 6-DOF camera pose from a single RGB image. We use a spatial grid that splits the target space into cells and apply position regression after classifying the viewpoint into a cell. Combining with the adaptive loss and spatial LSTMs, our method outperforms existing approaches by a large margin in both indoor and outdoor scenarios. Furthermore, we present a new integrated indoor and outdoor localization dataset. Results on both public and our datasets show that our method can improve both positional and orientational precision, especially for large scenes.