Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring the Psychosocial Factors between Adaptive and Maladaptive Use of Gaming among Korean Adolescents

(1) Background: Various studies have been conducted on the effects of video (online, mobile, and console) games on users’ lives and psychological health. However, the effectiveness of a game can vary depending on user characteristics. This study explored the level of game use and its associated psychosocial factors among adolescents. (2) Methods: Survey data were compiled from 582 middle and high school students. Frequency analysis, the chi-square test, and analysis of variance were performed using SPSS Windows software, version 23.0. (3) Results: First, it was confirmed that there were no differences in the levels of self-esteem, morality, or life satisfaction between the adaptive game use and normal groups, but these were higher than those of the maladaptive game use group. However, at the level of self-control, the adaptive group scored lower than the normal group but higher than the maladaptive group. Second, the adaptive and normal groups exhibited comparatively lower levels of aggression, anxiety, depression, loneliness, academic stress, and social stress in school. Third, they also exhibit relatively high levels of social intelligence, social capital, and friendship support. (4) Conclusions: The adaptive and general game-use groups showed similar levels of psychosocial factors, whereas the maladaptive game-use group exhibited lower levels of positive psychological and social factors. Based on these results, developing an intervention program that reduces maladaptation and increases adaptive gaming use is necessary. Future follow-up studies are needed to confirm how positive and negative psychosocial factors affect adaptive and maladaptive game use as protective and risk factors, respectively.
Emotional tendencies in online social networking: a statistical analysis

ABSTRACT Numerous previous studies suggested that people's emotional tendency (ET) towards an issue can often be affected by others. But in some cases, people are unwilling to believe opposite points. This paper aims to study whether people's emotional tendencies (ET) are susceptible with exposures to others' ET concerning a special topic. ET contained in 798,057 pieces of private-information-deleted Chinese Weibo posts are carefully investigated via a revised genetic algorithm, a nonlinear method. Note that nearly all of the posts are closely related to a special topic, the terrible earthquake happen in Japan, 11 March 2011. By conducting statistical analysis including coefficient calculations and hypothesis testing, this study shows that concerning this particular topic, Chinese citizens' first impressions about Japan are solid enough to form their ET and would not be easily altered. Moreover, according to analysis and discussion, we discover that node-to-node impact is exaggerated in some theoretical information diffusion models. Instead it is actually the interaction between nodes' properties and the spread information that matters in the process of information diffusions.
Optimized Peppermint Essential Oil Microcapsules Loaded into Gelatin-Based Cryogels with Enhanced Antimicrobial Activity

In this study, chitosan (Chi) was used to microencapsulate peppermint essential oil (PEO). A novel gelatin-based cryogel loaded with PEO microcapsules was further developed and characterized for potential applications. Four different cryogel systems were designed, and the morphological, molecular, physical and antibacterial properties were investigated. Additionally, the antimicrobial properties of PEO, alone and microcapsulated, incorporated into the cryogel network were evaluated. The observed gel structure of cryogels exhibited a highly porous morphology in the microcapsules. The highest values of the equilibrium swelling ratio were acquired for the GelCryo–ChiCap and GelCryo–PEO@ChiCap samples. The contact angle GelCryo–PEO@ChiCap sample was lower than the control (GelCryo) due to the water repelling of the essential oil. It has been found that the incorporation of encapsulated PEO into the cryogels would be more advantageous compared to its direct addition. Moreover, GelCryo–PEO@ChiCap cryogels showed the strongest antibacterial activities, especially against Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria). The system that was developed showed promising results, indicating an improved antibacterial efficacy and enhanced structural properties due to the presence of microcapsules. These findings suggest that the system may be an appropriate candidate for various applications, including, but not limited to, drug release, tissue engineering, and food packaging. Finally, this system demonstrates a strategy to stabilize the releasing of the volatile compounds for creating successful results.
Reservoir Reliability as Affected by Climate Change and Strategies for Adaptation

Reservoir operational reliability indicates how satisfactorily the structure meets the water demand without failure. However, due to the stochastic nature of its operation, every combination of reservoir storage capacity and draft has an associated probability of failure (i.e., of having an empty reservoir). The objectives of this research were to design a method to assess reservoir reliability under present and future climate conditions, and to apply it to the Descoberto reservoir, with a capacity of 86 hm3 and a design draft of 182.9 hm3 yr−1, located in central Brazil. The scenarios were the historic (1986–2005) and future RCM projection ensembles (2031–2050 and 2061–2080, RCP 4.5 and 8.5). Projected runoff was obtained with the Gardner model, and the reservoir budget was assessed by the concatenated behavior analysis (CBA). The reliability of the Descoberto reservoir, which was 100% during the historic period, was reduced to 15–50%, depending on the future climate scenario analyzed. The proposed adaptive measures, involving the reduction of reservoir draft and the increase in reservoir storage, were capable of maintaining a 100% reservoir reliability under the new climatic conditions, but with associated costs. The proposed method can be applied to other upstream reservoirs, providing water managers and stakeholders with a simple and robust reliability assessment and climate adaptation tool.
The C-Terminus of Panusin, a Lobster β-Defensin, Is Crucial for Optimal Antimicrobial Activity and Serum Stability

β-defensins are one of the most abundant and studied families of antimicrobial peptides (AMPs). Because of their selective toxicity to bacterial membranes and a broad spectrum of microbicidal action, β-defensins are regarded as potential therapeutic agents. This work focuses on a β-defensin-like AMP from the spiny lobster Panulirus argus (hereafter referred to as panusin or PaD). This AMP is structurally related to mammalian defensins via the presence of an αβ domain stabilized by disulfide bonds. Previous studies of PaD suggest that its C-terminus (Ct_PaD) contains the main structural determinants of antibacterial activity. To confirm this hypothesis, we made synthetic versions of PaD and Ct_PaD to determine the influence of the C-terminus on antimicrobial activity, cytotoxicity, proteolytic stability, and 3D structure. After successful solid-phase synthesis and folding, antibacterial assays of both peptides showed truncated Ct_PaD to be more active than native PaD, confirming the role of the C-terminus in activity and suggesting that cationic residues in that region enhance binding to negatively charged membranes. On the other hand, neither PaD nor Ct_PaD were hemolytic or cytotoxic in human cells. Proteolysis in human serum was also studied, showing high (>24 h) t1/2 values for PaD and lower but still considerable for Ct_PaD, indicating that the missing native disulfide bond in Ct_PaD alters protease resistance, albeit not decisively. NMR-2D experiments in water agree with the results obtained by circular dichroism (CD), where in SDS micelles, CD showed both peptides adopting an increasingly ordered structure in a hydrophobic environment, in tune with their ability to perturb bacterial membrane systems. In conclusion, while the β-defensin features of PaD are confirmed as advantageous in terms of antimicrobial activity, toxicity, and protease stability, the results of the present work suggest that these same features are preserved, even enhanced, in the structurally simpler Ct_PaD, which must therefore be viewed as a valuable lead for the development of novel anti-infectives.
pH-Activated Dissolvable Polymeric Coatings to Reduce Biofouling on Electrochemical Sensors

Implantable electrochemical sensors that enable the real-time detection of significant biomarkers offer huge potential for the enhancement and personalisation of therapies; however, biofouling is a key challenge encountered by any implantable system. This is particularly an issue immediately after implantation, when the foreign body response and associated biofouling processes are at their most active in passivating a foreign object. Here, we present the development of a sensor protection and activation strategy against biofouling, based on coatings consisting of a pH-triggered, dissolvable polymer, that covered a functionalised electrode surface. We demonstrate that reproducible delayed sensor activation can be achieved, and that the length of this delay can be controlled by the optimisation of coating thickness, homogeneity and density through tuning of the coating method and temperature. Comparative evaluation of the polymer-coated and uncoated probe-modified electrodes in biological media revealed significant improvements in their anti-biofouling characteristics, demonstrating that this offers a promising approach to the design of enhanced sensing devices.
Profil Antisipasi Siswa SMA Dalam Memecahkan Masalah Integral

Penelitian ini dilatarbelakangi oleh sulitnya siswa dalam menyelesaikan masalah integral khusunya luas daerah. Banyak siswa hanya menyelesaikan masalah integral hanya berdasarkan rumus yang sudah disediakan. Siswa jarang mengaitkan konsep-konsep yang saling terkait, dalam hal ini konsep integral subpokokbahasan luas daerah.Tujuan penelitian ini untuk mendeskripsikan Profil antisipasi siswa SMA dalam memecahkan masalah integral. Hasil penelitian ini dapat dimanfaatkan oleh guru untuk membantu siswa mengaitkan konsep-konsep yang belum terkait. Penelitian ini menggunakan metode tes dan wawancara. Tes berupa tes kemampuan matematika yang diberikan kepada siswa, sehingga diperoleh siswa berkemampuan tinggi dan wawancara diberikan kepada siswa yang bersangkutan untuk menggali dan melihat jaringan konsep yang dimiliki siswa dalam menyelesaikan masalah integral. Subjek dalam penelitian ini termasuk dalam antisipasi terinternasilsasi dikarenakan siswa secara spontan menerapkan rumus integral tanpa menganalisis soal yang diberikan. This research is motivated by the difficulty of students in solving integral problems especially the area. Many students just completed the integral problems just based on a formula that has been provided. Students rarely associate the concepts are interrelated, in this case the integral concept of the area. The purpose of this study was to describe the profile anticipation of high school students in problem solving integrals. The results could be used by teachers to help students link the concepts are not related. This study uses tests and interviews. The t ests such as math skills test given to students, in order to obtain a high ability students and interviews given to the student to explore and see the network concept of the students in problem solving integrals. Subjects in this study are included in anticipation terinternasilsasi because students spontaneously apply the integral formula without analyzing the questions that were given
The (Un)Equal Effect of Binary Socialisation on Adolescents’ Exposure to Pornography: Girls’ Empowerment and Boys’ Sexism from a New Representative National Survey

Due to the increasing trend in the use of pornography recorded in recent years, along with the decreasing age of its consumers, many studies have investigated its potential negative effects on adolescents, who are developing their social and sexual identity, often producing inconsistent results. With the present study, which is based on a large representative sample of Italian students attending public upper secondary schools, predictors as well as negative and positive effects of pornography use on adolescents’ attitudes, beliefs and well-being have been identified through a psychosocial approach. To achieve these results, the study involved a two-step analysis: first, the decision tree method for classification was applied to identify the main predictors of different frequencies in pornography consumption; subsequently, multinomial logistic regressions were carried out to detect the effects of pornography use. The results show a large difference between boys and girls in terms of frequency of pornography use, but also in the effects on adherence to gender roles, which is related to a still strongly stereotyped socialisation. Instead, similar negative effects on both girls and boys were found on self-esteem, body satisfaction, negative primary emotions and distress, suggesting the need for adequate sex education provided by both parents and schools to counteract taboos and blind internalisation of models of beauty and sexual behaviours provided by pornography.
Rapid Multi-Residue Method for Simultaneous Determination of 1,3,5-Triazine Herbicides in Environmental Samples by Capillary GC-MS-EI Selective Ion Monitoring Method

A new multi-residue method using gas chromatography–mass spectrometry electron ionization selective ion monitoring mode (SIM) has been developed for the simultaneous determination of eight 1,3,5-triazine herbicides such as 1,3,5-triazine-2,4-diamine (atrazine), ametryn, prometryn, propazine, terbuthylazine, terbutryn, and simazine simetryn in water and soil samples. Quantification is done using lindane (gamma benzene hexachloride) as an internal standard. A specific Capillary DB-Wax column of 30 m length, 0.32 mm internal diameter, and 0.25 µm film thickness is used for the separation of eight 1,3,5-triazine-2,4-diamine. The method was applied for the determination of residues in groundwater and soil samples. The lowest detection limit by GC-MS-SIM (selective ion monitoring mode) is 0.1 pg/mL. Recovery in water samples is in the range of 93–103%, and in soil samples, 91–102% for different individual compounds. Forty-five groundwater and soil samples were collected in and around Kancheepuram district in Tamilnadu (India), and they were analyzed for the respective residues. A detailed discussion of the GC-MS analysis results has been presented.
Assessing the National Water Model’s Streamflow Estimates Using a Multi-Decade Retrospective Dataset across the Contiguous United States

The goal of this study is to evaluate the performance of the National Water Model (NWM) in time and space across the contiguous United States. Retrospective streamflow simulations were compared to records from 3260 USGS gauging stations, considering both regulated and natural flow conditions. Statistical metrics, including Kling–Gupta efficiency, Percent Bias, Pearson Correlation Coefficient, Root Mean Squared Error, and Normalized Root Mean Squared Error, were employed to assess the agreement between observed and simulated streamflow. A comparison of historical trends in daily flow data between the model and observed streamflow provided additional insight into the utility of retrospective NWM datasets. Our findings demonstrate a superior agreement between the simulated and observed streamflow for natural flow in comparison to regulated flow. The most favorable agreement between the NWM estimates and observed data was achieved in humid regions during the winter season, whereas a reduced degree of agreement was observed in the Great Plains region. Enhancements to model performance for regulated flow are necessary, and bias correction is crucial for utilizing the NWM retrospective streamflow dataset. The study concludes that the model-agnostic NextGen NWM framework, which accounts for regional performance of the utilized model, could be more suitable for continental-scale hydrologic prediction.
The Effect of Caffeine Supplementation on Resistance and Jumping Exercise: The Interaction with CYP1A2 and ADORA2A Genotypes

Purpose: To evaluate the association of CYP1A2 and ADORA2A gene polymorphisms, paraxanthine concentrations, and habitual caffeine (CAF) intake with respect to muscular performance after acute CAF supplementation. Methods: A total of 27 resistance-trained males participating in the study ingested either 5 mg/kg of CAF or PL 45 min before a battery of exercise tests in a cross-over design. DNA was tested for the rs5751876 and rs762551 polymorphisms. Results: CAF improved performance in jumping average power, average velocity, max velocity, bench press in the first set, and peak power in the second set. For the CYP1A2 genotype, C allele carriers improved in jumping average velocity (CAF: 1.77 ± 0.14 m/s, PL: 1.71 ± 0.16 m/s, p < 0.001), and AA homozygotes improved set 1 bench press (CAF: 9.7 ± 1.7 reps, PL: 8.9 ± 1.8 reps, p = 0.046). For the ADORA2A genotype, CC (CAF: 1.70 ± 0.20 m/s, PL: 1.67 ± 0.19 m/s, p = 0.005) and CT (CAF: 1.79 ± 0.09 m/s, PL: 1.74 ± 0.11 m/s, p < 0.001) improved in jumping average velocity and CT also improved in bench press set 2 peak power (CAF: 363 ± 76 W, PL: 323 ± 59 W, p = 0.021). For CAF habituation, CAF improved jumping average power (p = 0.007) and jumping average velocity (p < 0.001) in high users but not in low users (p > 0.05). Conclusions: CAF may improve jumping and bench press performance, irrespective of genotypes, but the associations with the genotypes in CYP1A2 and ADORA2A genes, as well as habitual CAF intake, are not clear and require further investigation.
Neutralizing Antibodies against the SARS-CoV-2 Ancestral Strain and Omicron BA.1 Subvariant in Dogs and Cats in Mexico

SARS-CoV-2 mainly affects humans; however, it is important to monitor the infection of companion and wild animals as possible reservoirs of this virus. In this sense, seroprevalence studies in companion animals, such as dogs and cats, provide important information about the epidemiology of SARS-CoV-2. This study aimed to evaluate the seroprevalence of neutralizing antibodies (nAbs) against the ancestral strain and the Omicron BA.1 subvariant in dogs and cats in Mexico. Six hundred and two samples were obtained from dogs (n = 574) and cats (n = 28). These samples were collected from the end of 2020 to December 2021 from different regions of Mexico. The presence of nAbs was evaluated using a plaque reduction neutralization test (PRNT) and microneutralization (MN) assays. The results showed that 14.2% of cats and 1.5% of dogs presented nAbs against the ancestral strain of SARS-CoV-2. The analysis of nAbs against Omicron BA.1 in cats showed the same percentage of positive animals but a reduced titer. In dogs, 1.2% showed nAbs against Omicron BA.1. These results indicate that nAbs were more frequent in cats than in dogs and that these nAbs have a lower capacity to neutralize the subvariant Omicron BA.1.
Polyphenols Profile and Antioxidant Activity Characterization of Commercial North Italian Ciders in Relation to Their Geographical Area of Production and Cidermaking Procedures

Twenty-four samples of differently produced commercial Italian cider were analyzed for their polyphenols profile and antioxidant activity. A partial least square regression was used to correlate the ciders’ antioxidant activity with their polyphenolic content. Statistical analyses revealed only a clustering pattern in the samples based on their geographical area of production (North-West, NW, vs. North-East, NE). Indeed, NW ciders, compared to NE ones, showed higher antioxidant activity and higher contents of procyanidin B1, catechin, chlorogenic acid, epicatechin, and total polyphenols. On the contrary, no clear-cut clustering pattern determined by cidermaking procedures (i.e., Charmat or Champenoise method) has been observed. These data suggest that the differences observed between NW and NE ciders might be accounted uniquely to the use of different apple varieties and/or the maturation status, as well as the pedoclimatic conditions of their production areas and not for cellar procedures’ specificity.
Prevalence of Drug–Drug Interactions in Primary Care Prescriptions in Egypt: A Cross-Sectional Retrospective Study

In clinical practice, drug–drug interactions (DDIs) pose significant risks to a large number of patients. Consequently, healthcare providers are required to diligently identify, monitor, and effectively handle these interactions in order to enhance patient outcomes. In Egypt, DDIs are poorly addressed, with no reports for DDIs in primary care. In our cross-sectional, retrospective, observational study, we collected a total of five thousand, eight hundred and twenty prescriptions across eight major governorates in Egypt. Prescriptions were collected over a span of 15 months between 1 June 2021 and 30 September 2022. These prescriptions were analyzed for potential DDIs using the Lexicomp® drug interactions tool. The prevalence of DDIs was found to be 18%, with 22% of the prescriptions having two or more potential DDIs. Moreover, we found 1447 DDIs of categories C (monitoring therapy recommended), D (therapy modification suggested), and X (avoid combination). The most commonly interacting drugs in our study were diclofenac, aspirin, and clopidogrel, while non-steroidal anti-inflammatory drugs (NSAIDs) were the most reported therapeutic class implicated in pharmacologic DDIs. Pharmacodynamic agonistic activity was the most common mechanism of interaction. Therefore, it is crucial to conduct screenings, detect early signs, and closely monitor drug–drug interactions (DDIs) to enhance patients’ overall health outcomes, medication responses, and safety. In this regard, the clinical pharmacist assumes a vital role in implementing these preventive measures.
Increased Risk of Developing Systemic Lupus Erythematosus and Rheumatoid Arthritis in Patients with Primary Sjögren’s Syndrome—A Secondary Cohort Analysis of Nationwide, Population-Based Claims Data

Background: This retrospective cohort study aimed to examine the risk of developing systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in patients with primary Sjögren’s syndrome (pSS) compared to controls using data from a nationwide health claims database. Methods: Four distinct cohorts of patients with newly diagnosed pSS were established using Taiwan’s National Health Insurance Research Database. Cohorts I and II were created to evaluate the risk of developing SLE and RA, respectively. Cohorts III and IV were assembled similarly to Cohorts I and II but employed a stricter definition, based on catastrophic illness certificate (CIC) status, for identifying patients with pSS. Comparison cohorts of patients without pSS were formed by frequency matching for sex, 5-year age interval, and index year. Incident rate ratios (IRR) for SLE or RA development were determined using Poisson regression models. Results: Patients with pSS, selected from just outpatient visits or with additional CIC status showed a significantly higher risk of developing SLE or RA compared with the controls. When stratified by age group or sex, the risk of developing SLE was notably higher in the young age group (adjusted IRR 47.24, p = 0.002) and women (adjusted IRR 7.63, p = 0.003) among patients with pSS. In addition, both men and women with pSS, irrespective of age, showed a significantly elevated risk of developing RA. Conclusions: Patients with pSS exhibited an elevated risk of developing SLE and RA. Rheumatologists should carefully monitor patients with pSS for potential SLE and RA development.