Miracle-dz/UniFAR-FTUs huggingface dataset:
Bromodomains and Extra-Terminal (BET) Inhibitor JQ1 Suppresses Proliferation of Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolysis

Background Acute lymphocytic leukemia (ALL) is a common blood cancer which induces high mortality in children. Bromodomains and extra-terminal (BET) protein inhibitors, such as JQ1 and ARV-825, are promising cancer therapeutic agents that can be used by targeting c-Myc. A recent work reported that JQ1 effectively attenuates ALL in vitro by suppressing cell proliferation and accelerating apoptosis. The purpose of this research was to probe into the potential mechanism of how JQ1 inhibits ALL cell proliferation in vitro. Material/Methods Cell viability of ALL cells were measured by CTG after treatment by JQ1. Cell cycle analysis was done by EdU and PI staining. Cell apoptosis was assessed by Annexin V/PI staining. Glycolysis was detected using Seahorse and LC-MS kits. The expression of glycolytic rate-limiting enzymes was assessed by RNA-seq, qRT-PCR, and Western blot. Results JQ1 suppressed cell proliferation by arresting the cell cycle and inducing the apoptosis of acute lymphocytic leukemia cells. JQ1 inhibited cell proliferation of B-ALL cells by restraining glycolysis. Conversely, the cell cycle block of B-ALL cells induced by JQ1 was partially abolished after pretreatment with 2-Deoxy-D-glucose (2-DG), an inhibitor of glycolysis. Furthermore, JQ1 restrained the glycolysis of B-ALL cell lines by remarkably downregulating the rate-limiting enzymes of glycolysis, such as hexokinase 2, phosphofructokinase, and lactate dehydrogenase A. Moreover, the cell cycle arrest was reversed in B-ALL cells with overexpressed c-Myc treated by JQ1, which is involved in the enhancement of glycolysis. Conclusions The BET inhibitor JQ1 suppresses the proliferation of ALL by inhibiting c-Myc-mediated glycolysis, thus providing a new strategy for the treatment of ALL.
Ethainter: a smart contract security analyzer for composite vulnerabilities

Smart contracts on permissionless blockchains are exposed to inherent security risks due to interactions with untrusted entities. Static analyzers are essential for identifying security risks and avoiding millions of dollars worth of damage. We introduce Ethainter, a security analyzer checking information flow with data sanitization in smart contracts. Ethainter identifies composite attacks that involve an escalation of tainted information, through multiple transactions, leading to severe violations. The analysis scales to the entire blockchain, consisting of hundreds of thousands of unique smart contracts, deployed over millions of accounts. Ethainter is more precise than previous approaches, as we confirm by automatic exploit generation (e.g., destroying over 800 contracts on the Ropsten network) and by manual inspection, showing a very high precision of 82.5% valid warnings for end-to-end vulnerabilities. Ethainter’s balance of precision and completeness offers significant advantages over other tools such as Securify, Securify2, and teEther.
Moving enterprise resource planning (ERP) systems to the cloud: the challenge of infrastructural embeddedness

Cloud enterprise resource planning (ERP) solutions allow organizations to support and coordinate key business processes by leveraging virtualization. Nevertheless, moving ERPs to the cloud is not straightforward, and organizational cloud ERP initiatives raise multiple concerns. We conducted an in-depth systematic review of relevant research literature and identified six key concerns related to cloud ERP implementation: a) the introduction of new ERP work arrangements, b) the migration of legacy data, c) the assurance of compliance with extant rules and regulations for security, d) the continuous alignment between ERP functionality and business processes, e) the ongoing integration between ERPs and the rest of the organization’s application portfolio, and f) the establishment of adequate reliability levels. The identified concerns are associated with both transition management and operations supported by cloud ERPs. All the identified concerns are also related to the need to achieve infrastructural embeddedness. This need sets ERPs apart from other types of cloud-based applications, such as office automation solutions that do not have as many dependencies and exchanges with other systems and repositories within an organization’s information infrastructure. We argue that the challenge of embeddedness has different implications for organizations of different sizes, and we call for further empirical research.
The Relationship between Previous Lower Extremity Injury, Body Weight and Bilateral Eccentric Hamstring Strength Imbalance in Young Soccer Players

Th is study aims to investigate the eff ect of lower extremity (LE) injuries on bilateral hamstring eccentric strength imbalance (HSI) and to determine the relationship between body weight (BW) and HSI in young male soccer players. Eighty-eight young soccer players aged 14-19 in Turkey voluntarily participated in this study. Eccentric hamstring strength measurements were taken using a NordBord® Hamstring Testing Device. To obtain the LE backgrounds of the participants, individual interviews were administered to the players, and the obtained data were verifi ed through a review of previous injury records. While 22 (25%) out of 88 players reported LE injuries in the previous two years (injured players (IP)), the rest of them (75%) did not report any LE injuries (non-injured players (NP)). HSI values as peak forces were computed by extracting the weaker leg values from the stronger leg values. Both the Analysis of Variance (ANOVA) and the Analysis of Covariance (ANCOVA) were performed, controlling the BW eff ect in order to test the eff ects of LE injuries on HSI. Correlation analysis was also conducted, taking into consideration the previous research fi ndings on the relationship between body weight and strength variables. Th ere was signifi cant relationship between BW and HSI ((p<0.05) (0.04> r >0.02)) and non-signifi cant results for HSI (F (1.85) =0.578, p>0.05). However, the eff ect of BW was signifi cant for HSI (F (1.85) =3.91, p<0.05, η2 = 0.068). Th is study supported the hypothesis that hamstring muscle strength imbalance is not aff ected by lower extremity injuries and that body weight is a factor that may aff ect strength imbalance.
lymphoblastic leukemia cells Genomewide identification of prednisolone-responsive genes in acute

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MLCVNet: Multi-Level Context VoteNet for 3D Object Detection

In this paper, we address the 3D object detection task by capturing multi-level contextual information with the self-attention mechanism and multi-scale feature fusion. Most existing 3D object detection methods recognize objects individually, without giving any consideration on contextual information between these objects. Comparatively, we propose Multi-Level Context VoteNet (MLCVNet) to recognize 3D objects correlatively, building on the state-of-the-art VoteNet. We introduce three context modules into the voting and classifying stages of VoteNet to encode contextual information at different levels. Specifically, a Patch-to-Patch Context (PPC) module is employed to capture contextual information between the point patches, before voting for their corresponding object centroid points. Subsequently, an Object-to-Object Context (OOC) module is incorporated before the proposal and classification stage, to capture the contextual information between object candidates. Finally, a Global Scene Context (GSC) module is designed to learn the global scene context. We demonstrate these by capturing contextual information at patch, object and scene levels. Our method is an effective way to promote detection accuracy, achieving new state-of-the-art detection performance on challenging 3D object detection datasets, i.e., SUN RGBD and ScanNet. We also release our code at https://github.com/NUAAXQ/MLCVNet.
Multispectral optoacoustic tomography for imaging of disease biomarkers

Multispectral optoacoustic tomography (MSOT) is an emerging modality based on ultrasound detection of optical absorption via the photoacoustic effect. The technique allows the visualisation of intrinsic optical tissue contrast, as well as a multitude of exogenous contrast agents at the high resolution provided by ultrasound. This dissertation describes the critical methods developed and corresponding results obtained during a research effort aimed at evaluation of the technique in the context of in-vivo biomarker imaging. Studies were performed on mouse models of cancer and cardiovascular disease. In summary, MSOT was discovered to enable a number of applications, from the small animal imaging as described in this work, to future clinical translation.
Optical properties of disordered metallic photonic crystal slabs

We give an overview about the optical properties of disordered metallic photonic crystal slabs. Different disorder models with different next‐neighbor correlations are artificially introduced into the samples, and their influence on the samples' transmission and bandstructure are examined. We found that uncorrelated disorder reduces the amplitude of spectral features and the width of the stop‐bands in the bandstructure. Correlated disorder additionally excites multiple resonances, resulting in broadened resonances and a destroyed bandstructure even at moderate disorder. Numerical results are presented that allow to fully interpret the experimental observations. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Characterization of candidate genes for bovine adipogenesis reveals differences of TUSC5 isoforms caused by novel alternative splicing

// Yang Zhou 1 , Mingxun Li 1, 2 , Xinde Hu 3, 4 , Hanfang Cai 1 , Liushuai Hua 1, 5 , Jing Wang 1, 5 , Yongzhen Huang 1 , Xianyong Lan 1 , Chuzhao Lei 1 , George E. Liu 6 , Congjun Li 6 , Martin Plath 1 and Hong Chen 1 1 College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Agricultural Molecular Biology, Yangling, Shaanxi 712100, China 2 College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu 225009, China 3 Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China 4 College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China 5 Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Henan Key Laboratory of Animal Breeding and Nutritional Regulation, Zhengzhou, Henan 450002, China 6 Animal Genomics and Improvement Laboratory, BARC, USDA-ARS, Beltsville, Maryland 20705, USA Correspondence to: Hong Chen, email: chenhong1212@263.net Keywords: cattle, lipid accumulation, TUSC5, alternative splicing, subcellular localization Received: August 22, 2017 Accepted: October 05, 2017 Published: January 02, 2018 ABSTRACT Different transcripts generated by alternative splicing have led to new insights to reconsider gene functions. Here, by progressively screening 31 candidate genes, we detected 3 genes that could be regulated by the peroxisome proliferator activated receptor gamma 2 (PPARG2), one isoform of the PPARG that specifically expressed in adipose tissue. Alternative splicing events of two genes regulated by PPARG2 - cell death-inducing DFFA-like effector c ( CIDEC ) and tumor suppressor candidate 5 ( TUSC5 ) — were further investigated. Similar results regarding their subcellular localization were observed for two isoforms of CIDEC. We validated the existence and coding ability of a novel TUSC5 transcript (TUSC5a). Differences became apparent between the two TUSC5 transcript isoforms in terms of expression and subcellular localization, possibly caused by a 29 amino acid insertion. The expression of the TUSC5a was significantly delayed, and showed that uniquely expressed in adipose tissue and differently expressed with TUSC5b during adipocyte differentiation. Subcellular localization analyses showed that both TUSC5 isoforms existed in the endplasmic reticulum but with different localization and no interaction with CIDEC isoforms. In summary, our candidate gene-based approach provides further depth to our understanding of the process of adipogenesis, highlighting the functional diversity of one gene generated by alternative splicing.
Seroprevalence of Anti - Toxoplasma Antibodies Among Women of Child Bearing Age in Duhok Province

A total number of 1146 blood samples taken randomly from single and married women at child bearing age of different ages, different socioeconomic and educational classes in Duhok city. They were examined to detect anti-toxoplasma IgG and IgM Abs by using LAT and ELISA tests. The rate of seroprevalence was 38.7 % by using LAT, while it was 27.7 % by using ELISA IgG. On the other hand, the rate of anti-toxoplasma IgM Abs was only 0.4 % by using ELISA. Significant differences were observed in rate of seropositivity between single and married women, and also between various age groups, the highest rate (45.3%) was observed among the age group 31-35 years. Also significant seropositive rates were observed between all educational levels with the highest rates (36.4% and 34.2%) being among illiterate and house wives, respectively. Contact with cats or eating undercooked meat has no effect on seropositivity rate. Regarding married status, pregnant women showed highest seropositivity (49.7%) especially at first trimester of gestation.
Benson's Relaxation Therapy: Its effect on Stress and Coping among Mothers with High Risk Pregnancy

Aim: This study aimed to investigate the effects of Benson's relaxation therapy on stress and coping among mothers with high risk pregnancy.Methods: Design: A quasi experimental Pre-Post-test design. Sample type: Purposive sampling was applied. Setting: The study was carried out at High Risk Pregnancy Unit in Mansoura University Hospital on 50 mothers with high risk pregnancy between 24 to 36 weeks of gestation in a period from October, 2016 to March, 2017. Tools: A Structured Interviewing Questionnaire, Perceived Stress Scale and Coping Patterns Scale.Results: The average score of stress scale was significantly decreased post-intervention (13.84 Â± 2.53) compared to (24.62Â± 2.84) pre-intervention and the average scores of all domains of coping were significantly improved post- intervention (P = 0.001). There was a significant difference between the average score of stress scale with education of the mothers pre-intervention (P = 0.001) and it was eliminated post- intervention. Also, there was a significant difference between the average score of coping with stress and gravidity of the mothers pre-intervention (p = 0.05) and it was eliminated post-intervention. There was a significant negative moderate correlation between total stress score and total coping score pre and post-intervention (r = -0.511, r = -0.651, p = 0.001, respectively) that it means when the stress decreases, the coping is better.Conclusion: It has been proved that the Bensonâ€™s relaxation therapy serves as a resource for improving maternal psychological health by reducing stress and enhancing coping among high risk pregnant mothers.Recommendation: The maternity nursing services are recommended to use the Benson relaxation therapy as one of the standard non-pharmacological managements inÂ a high risk unit.
Mental health problems due to community violence exposure in a small urban setting

Objective Studies conducted in large metropolitan inner-city communities with high violent crime rates have demonstrated an association between exposure to violence and mental health problems; therefore the purpose of this study was to determine if similar trends exist in smaller inner-city communities with substantially lower violent crime rates. Methods One hundred twenty-six children and young adults living in inner-city Omaha, Nebraska, were screened for posttraumatic stress disorder (PTSD), depression, and anxiety symptoms and assessed for community violence exposure (CVE). Pearson’s correlation and analysis of variance were used to determine the relationship between PTSD, depression, and anxiety symptoms and CVE. Results A statistically significant relationship was found between CVE and PTSD and anxiety symptoms among participants despite their having lower rates of exposure to violent events in comparison with other studies. No association was found between violence and depression symptoms. Additionally, the presence of anxiety and depression, as well as increased age of participants, was associated with higher rates of PTSD symptoms. Conclusion We recommend that health care providers in smaller cities, where the effects of violent crime may be underestimated or overlooked, be informed of the existence of this public health problem within their community and that they screen at-risk patients for mental health problems.
Medicovi H20 insoles test: variability of centre of pressure in healthy people during dynamic standing and gait

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Impact of cardiopulmonary resuscitation training in 1st year of MBBS

Background: The present medical education system fails to inculcate appropriate skills and competence to the students to serve the community. As the world is moving toward the system of â€œneed-based education,â€ the training of the undergraduates should be oriented toward acquiring practical skills to prepare them to confidently deal with emergency situations in future. Objectives: The objective of this study is to estimate the impact of cardiopulmonary resuscitation (CPR) training in the 1st year of MBBS. Materials and Methods: The study included 150 MBBS 1st year students. The students were given formal training of CPR which included the lecture followed by a hands-on training of CPR on mannequins. The pre-and post-training assessment of the students was done using questionnaire. Assessment of the skill was done by direct observation of the procedure on a mannequin by a checklist. Results: The average pre-training score was 6.39 Â± 2.11 and post-training score was 16.56 Â± 1.89. The post-training scores of the student were remarkably better than the pre-training score (P < 0.001). According to the results of the assessment of skill by direct observation, students scored better initially in the first part, i.e., knowledge section and the score in the second part, i.e., skill demonstration improved gradually with practice. Conclusion: Training the MBBS students about CPR in 1st year itself is very useful and productive. Training the future health care provider in younger age and preparing them for the emergencies will lead to major reform in the health education system.
Numerical studies on 2-dimensional reaction-diffusion equations

Abstract Various initial and boundary value problems for a 2-dimensional reaction-diffusion equation are studied numerically by an explicit Finite Difference Method (FDM), a Galerkin and a Petrov-Galerkin Finite Element Method (FEM). The results not only show the transition processes from different local initial disturbances to quasitravelling waves, but also demonstrate the long term behaviour of the solutions, which is determined by the system itself and does not depend on the details of the initial disturbances.
Clinicopathological profile, diagnosis and treatment of skin cancers at a tertiary care center: a retrospective study

Malignant skin lesions have become increasingly prevalent over the past several years. In United States, approximately 5.4 million cases of non-melanoma skin cancers are treated in 2012. Skin cancer account for more than 40% of all malignancies. Majority of skin cancers are basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma which account for more than 95% of total skin malignancies.
AN ANALYSIS OF THE EFFECTIVENESS AND QUALITY OF ELEARNING IN MEDICAL EDUCATION

Technology advancement has a major impact on the prevailing education methods and ways to present knowledge. More and more frequently, blended learning or even e-learning methods are implemented along with traditional education. On the other hand, rapid changes in medical sciences involve the need to continuously extend and update the teaching contents. All this contributes to seeking an optimized and efficient method of imparting knowledge in medical education on academic level, to maximize the learning results without imposing excessive load on the teaching staff. Comparison of learning effects and student satisfaction is the primary method of checking whether the implemented changes in learning methods and context bring positive results.This article presents an evaluation of methods of measuring learning efficiency and quality on the basis of classes held in selected medical subjects at the Faculty of Health Sciences of the Medical University of Bialystok and the results of the implementation of an electronic examination at the Faculty of Medicine, Department of Pathophysiology, The Poznan University of Medical Sciences. Efficiency of traditional education was compared to that of distance learning, involving the use of an e-learning portal implemented for research purposes. The results of research on e-examination may constitute the basis for a discussion concerning electronic knowledge evaluation in medical education and an example implementation for those medical schools that are now commencing e-testing. W. Półjanowicz, M. Roszak, B. Kołodziejczak, A. Bręborowicz 178
Prevalencia de insuficiencia y deficiencia de vitamina D en adultos mexicanos con asma alérgica

Background: Hypovitaminosis D has been associated with various chronic diseases such as infections, autoimmune diseases, chronic obstructive pulmonary disease, cancer and asthma Objective: The objective at hand is to determine the prevalence of vitamin D (VD) insufficiency and deficiency in adults with allergic asthma. Methods: Through a cross-sectional study, we analyzed corresponding data amongst 135 patients. VD concentration was categorized as sufficient (≥ 30 ng/mL), insufficient (21-29 ng/mL), and deficient (≤ 20 ng/mL). The level of VD deficiency was measured through chemo-luminescence. We estimated the prevalence of VD alterations and their respective confidence intervals at 95 % (CI 95 %). Results: Within the analyzed population, there were 99/135 women (73.3 %); the mean age was 34.5 ± 10.3 years. The mean concentration of VD was 17.9 ± 6.9 ng/mL and the median was 17 ng/mL. The prevalence of VD insufficiency and deficiency was 25.2 % (CI 95 %, 18.6-33.2 %) and 71.1 % (CI 95 %, 62.9-78.1 %), respectively; VD concentrations ≤ 10 ng/mL had 13.3 % (CI 95 %, 8.5-20.2 %) and ≥ 30 ng/mL at 3.7 % (CI 95 %: 1.4-8.6 %). When we contrasted the men to the women, the median concentration of VD did not differ significantly (16 ng/mL vs. 18 ng/mL, p = 0.71). Conclusions: In this study, patients with allergic asthma had distinctively reduced VD concentration levels; future research will determine if and how VD affects the severity of asthma.