Miracle-dz/UniFAR-FTUs huggingface dataset:
Preliminary experience in laparoscopic distal pancreatectomy using the AEON™ endovascular stapler

Background The aim of this study is to investigate the effects of using a new innovative endovascular stapler, AEON™, on the pancreatic leak rates and other outcome measures. Methods In a retrospective review of prospectively collected data from a secure tertiary unit registry, patients undergoing distal or lateral pancreatectomy were analyzed for any differences on pancreatic fistula rates, length of stay, comprehensive complication index (CCI), and demographics after using AEON™ compared with other commonly used staplers. Statistical significance was defined as <0.05. Results There were no differences in the demographics between the two groups totaling 58 patients over 2 years from 2019 to 2021. A total of 43 and 15 patients underwent pancreatic transection using other staplers and AEON™ endovascular stapler, respectively. The comparison of the two groups revealed a significantly reduced rate of mean drain lipase at postoperative day 3 with AEON™ (446 U/L) versus the other staplers (4,208 U/L) (p = 0.018) and a subsequent reduction of postoperative pancreatic fistula (POPF) from 65% to 20%. A reduction in the mean CCI, from 13.80 when other staplers were used to 4.97 when AEON™ was used, was also observed (p = 0.087). Mean length of stay was shorter by 3 days in the AEON™ group compared with that in the other staplers (6 and 9 days, respectively; p = 0.018). Conclusion AEON™ stapler when used to transect the pancreas demonstrated a significantly reduced pancreatic fistula rate, length of stay in hospital, and a leaning towards a reduced CCI. Its use should be further evaluated in larger cohorts with the encouraging results to determine whether this is possibly related to the technology used in the design of the AEON™ stapler.
Identities for Homogeneous Utility Functions

Using a homogeneous and continuous utility function that represents a household's preferences, this paper proves explicit identities between most of the different objects that arise from the utility maximization and the expenditure minimization problems. The paper also outlines the homogeneity properties of each object. Finally, we show explicit algebraic ways to go from the indirect utility function to the expenditure function and from the Marshallian demand to the Hicksian demand and vice versa, without the need of any other function, thus simplifying the integrability problem avoiding the use of differential equations.
Experimental and numerical analyses of the hydrodynamic performance of propeller boss cap fins in a propeller-rudder system

ABSTRACT This paper presents the simulated and experimental results of propeller-rudder systems with propeller boss cap fins (PBCFs) and analyzes the hydrodynamic performance of PBCFs in propeller-rudder systems. The purpose is to study the impact of PBCFs on the hydrodynamic performance of rudders. Hydrodynamic experiments were carried out on propeller-rudder systems with PBCFs in a cavitation tunnel. The experimental energy-saving effect of the PBCF without a rudder was 1.47% at the design advance coefficient J = 0.8. The numerical simulation was based on the Navier–Stokes equations solved with a sliding mesh and the SST (Shear Stress Transfer) k-ω turbulence model. After the grid independence analysis, the flow fields of an open-water propeller with and without a PBCF were compared, then the efficiencies of the propulsion systems including different rudders and the thrust coefficient Kr of rudders were analyzed. The results indicate that the installation of a PBCF increases the resistance of the rudder, which results in a reduction in the energy-saving effect of the PBCF. At the design advance coefficient, the energy-saving effect of the PBCF with an ordinary rudder and a twisted rudder decreases from 1.47% to 1.08% and 1.16%, respectively; thus, it is important to factor in the rudder of a propulsion system when evaluating the energy-saving effects of PBCFs .
Effect of Vortex Generators on the Flow Around a Circular Cylinder: Computational Investigation with Two-Equation Turbulence Models

Abstract: The paper presents a comparative study based on the 3D computational simulations of the flow around a circular cylinder fitted with vortex generators, benefiting from a series of dedicated model tests conducted in a large circulating water tunnel. The effect of the vortex generators is presented with comparisons including the bare cylinder with no vortex generator case and related experimental data. Incompressible, unsteady Reynolds- Averaged-Navier-Stokes (URANS) computations were performed by using three different two-equation turbulence models, which were Realizable k-ε, Wilcox k-ω, and Shear-Stress-Transport k-ω models. The numerical calculations emphasized the effectiveness and the performance enhancing character of the vortex generators. Many key findings of the measurements such as the elongation of the near-wake, the extension of the shear layers, the decrease of the stress components and the weakening of the vortices were successfully reproduced with the computations. Significant drag reduction was observed in both experimental and computational study due to the application of the vortex generators.
Generalized Pythagorean Theorem

The results in this paper arose from the efforts of the first-named author to adapt Horadams Fibonacci number triples [3] to generate direction of numbers in solid geometry for a multivariable calculus course. This effort was unsuccessful in that the equation obtained was true for quadratic d iophantine equations in general, but it did not use any properties of the Fibonacci sequence. However, it did give rise to some results for higher order sequences. Horadam [2] , [3] , [4] has studied the properties of a generalized Fibonacci sequence defined by
MicroRNA Expression Signatures in Clear Cell Renal Cell Carcinoma: High-Throughput Searching for Key miRNA Markers in Patients from the Volga-Ural Region of Eurasian Continent

Clear cell renal cell carcinoma (ccRCC) is characterized by high molecular genetic heterogeneity, metastatic activity and unfavorable prognosis. MicroRNAs (miRNA) are 22-nucleotide noncoding RNAs that are aberrantly expressed in cancer cells and have gained serious consideration as non-invasive cancer biomarkers. We investigated possible differential miRNA signatures that may differentiate high-grade ccRCC from primary disease stages. High-throughput miRNAs expression profiling, using TaqMan OpenArray Human MicroRNA panel, was performed in a group of 21 ccRCC patients. The obtained data was validated in 47 ccRCC patients. We identified nine dysregulated miRNAs (miRNA-210, -642, -18a, -483-5p, -455-3p, -487b, -582-3p, -199b and -200c) in tumor ccRCC tissue compared to normal renal parenchyma. Our results show that the combination of miRNA-210, miRNA-483-5p, miRNA-455 and miRNA-200c is able to distinguish low and high TNM ccRCC stages. Additionally, miRNA-18a, -210, -483-5p and -642 showed statistically significant differences between the low stage tumor ccRCC tissue and normal renal tissue. Contrariwise, the high stages of the tumor process were accompanied by alteration in the expression levels of miRNA-200c, -455-3p and -582-3p. Although the biological roles of these miRNAs in ccRCC are not totally clear, our findings need additional investigations into their involvement in the pathogenesis of ccRCC. Prospective studies with large study cohorts of ccRCC patients are important to further establish the clinical validity of our miRNA markers to predict ccRCC.
Design of Hardware Efficient Approximate DCT Architecture

Integer Discrete Cosine Transform (DCT) reduces hardware complexity by eliminating floating point multiplication. Multiplier less multiple constant multiplication (MCM) is used to further optimize integer multiplication by replacing it with shifters and adders. As N-point DCT takes 25% of hardware complexity in high efficiency video coding (HEVC), further optimizing DCT in terms speed and power remains critical. Lately, an alternate real-valued DCT coefficients were proposed which reduced the amount of scaling used in Integer DCT coefficients. It achieved the low dynamic range, high speed and low power at same degree of approximation for DCT coefficients. In this paper, an effort is made to further approximate real-valued DCT coefficients of N-point DCT so that critical path due to MCM is reduced. Proposed approximate real-valued DCT coefficients has relatively good PSNR with optimized hardware compared to existing real-valued DCT coefficients. FPGA implementation of 1D-DCT architecture for 32-point DCT with approximate real-valued coefficients shows the reduction of 35% and 24% in area-delay product and power respectively.
New Formulations on Motion Equations in Analytical Dynamics

Using the main author's researches on the energies of acceleration and higher order equations of motion, this paper is devoted to new formulations in analytical dynamics of mechanical multibody systems (MBS). Integral parts of these systems are the mechanical robot structures, serial, parallel or mobile on which an application will be presented in order to highlight the importance of the differential motion equations in dynamics behavior. When the components of multibody mechanical systems or in its entirety presents rapid movements or is in transitory motion, are developed higher order variations in respect to time of linear and angular accelerations. According to research of the main author, they are integrated into higher order energies and these in differential equations of motion in higher order, which will lead to variations in time of generalized forces which dominate these types of mechanical systems. The establishing of these differential equations of motion, it is based on a generalization of a principle of analytical differential mechanics, known as the D`Alembert – Lagrange Principle.
Vinylbenzyl Chloride/Styrene-Grafted SBS Copolymers via TEMPO-Mediated Polymerization for the Fabrication of Anion Exchange Membranes for Water Electrolysis

In this work, a commercial SBS was functionalized with the 2,2,6,6-tetramethylpiperidin-N-oxyl stable radical (TEMPO) via free-radical activation initiated with benzoyl peroxide (BPO). The obtained macroinitiator was used to graft both vinylbenzyl chloride (VBC) and styrene/VBC random copolymer chains from SBS to create g-VBC-x and g-VBC-x-co-Sty-z graft copolymers, respectively. The controlled nature of the polymerization as well as the use of a solvent allowed us to reduce the extent of the formation of the unwanted, non-grafted (co)polymer, thereby facilitating the graft copolymer’s purification. The obtained graft copolymers were used to prepare films via solution casting using chloroform. The –CH2Cl functional groups of the VBC grafts were then quantitatively converted to –CH2(CH3)3N+ quaternary ammonium groups via reaction with trimethylamine directly on the films, and the films, therefore, were investigated as anion exchange membranes (AEMs) for potential application in a water electrolyzer (WE). The membranes were extensively characterized to assess their thermal, mechanical, and ex situ electrochemical properties. They generally presented ionic conductivity comparable to or higher than that of a commercial benchmark as well as higher water uptake and hydrogen permeability. Interestingly, the styrene/VBC-grafted copolymer was found to be more mechanically resistant than the corresponding graft copolymer not containing the styrene component. For this reason, the copolymer g-VBC-5-co-Sty-16-Q with the best balance of mechanical, water uptake, and electrochemical properties was selected for a single-cell test in an AEM-WE.
MINIMAL TWO-VALUED ECCENTRIC SEQUENCES

An eccentric sequence of a connected finite graph is a sequence of eccentricities of its vertices. An eccentric sequence is called minimal if it has no proper eccentric subsequence with the same number of distinct eccentricities. We survey known results concerning minimal two-valued eccentric sequences and describe a new infinite class of these sequences. Also a conjecture on all minimal two-valued eccentric sequences is proposed. AMS Subject Classification: 05C12
Clinicopathological Significance of Cell Adhesion Molecule 4 Expression in Gallbladder Cancer and Its Prognostic Role

Cell adhesion molecule 4 (CADM4) is involved in intercellular interactions and is a tumor-suppressor candidate. The role of CADM4 in gallbladder cancer (GBC) has not been reported. Therefore, the clinicopathological significance and prognostic value of CADM4 expression in GBC were evaluated in the present study. Immunohistochemistry (IHC) was performed on 100 GBC tissues to assess CADM4 expression at the protein level. The association between CADM4 expression and the clinicopathological characteristics of GBC was analyzed, and the prognostic significance of CADM4 expression was evaluated. Low CADM4 expression was significantly associated with advanced T category (p = 0.010) and high AJCC stage (p = 0.019). In a survival analysis, low CADM4 expression was associated with shorter overall survival (OS; p = 0.001) and recurrence-free survival (RFS; p = 0.018). In univariate analyses, low CADM4 expression was associated with shorter OS (p = 0.002) and RFS (p = 0.023). In multivariate analyses, low CADM4 expression was an independent prognostic factor of OS (p = 0.013). Low CADM4 expression was associated with tumor invasiveness and poor clinical outcomes in patients with GBC. CADM4 may play an important role in cancer progression and patient survival and can be used as a potential prognostic marker of GBC.
‘If in Doubt, Sit Them Out’: How Long to Return to Elite Cycling Competition following a Sports-Related Concussion (SRC)?

Introduction: A concussion or sports-related concussion (SRC) is a traumatic brain injury induced by biomechanical forces. After a SRC diagnosis is made, a concussed individual must undergo a period away from competition while they return to their baseline level of functioning. The Union Cycliste Internationale (UCI) currently recommend a minimum of 6 days restriction from competitive cycling following a SRC but there is a growing feeling amongst those involved in brain injury research that this period is too short. Therefore, how much time should cyclists be removed from competitive sporting action following a SRC? Aims: To review the time out of competition following the diagnosis of a SRC for elite cyclists within British Cycling (BC). Methods: All medical records for elite cyclists within BC were audited for diagnoses of “concussion” or “sports-related concussions” from January 2017 until September 2022. The days out of competition following the concussion until ready to compete again (that is, returned to full training) was then calculated. All diagnoses and management of SRC were undertaken by the medical team at BC and in-keeping with current international guidelines. Results: Between January 2017 and September 2022, there were 88 concussions diagnosed, 54 being males and 8 in para-athletes. The median duration for time out of competition for all concussions was 16 days. There was no statistical difference between males (median 15.5 days) and females (median 17.5 days) for time out of competition (p-value 0.25). The median duration out of competition following a concussion for able-bodied athletes was 16 (80 athletes) compared to 51 days (8 athletes) in para-cyclists, which was not statistically different (p-value 0.39). Conclusions: This is the first study to report SRC concussion recovery times in elite cycling, including para-athletes. Between January 2017 and September 2022, there were 88 concussions diagnosed at BC and the median duration for time out of competition for all concussions was 16 days. There was no statistically significant difference in recovery times between male and females and para- and able-bodied athletes. This data should be used to help establish minimum withdrawal times post-SRC for elite cycling participation and we call on the UCI to review this data when establishing SRC protocols for cycling, with further research required in para-cyclists.
Dual Antiplatelet Therapy with Parenteral P2Y12 Inhibitors: Rationale, Evidence, and Future Directions

Dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and an inhibitor of the platelet P2Y12 receptor for ADP, remains among the most investigated treatments in cardiovascular medicine. While a substantial amount of research initially stemmed from the observations of late and very late stent thrombosis events in the first-generation drug-eluting stent (DES) era, DAPT has been recently transitioning from a purely stent-related to a more systemic secondary prevention strategy. Oral and parenteral platelet P2Y12 inhibitors are currently available for clinical use. The latter have been shown to be extremely suitable in drug-naïve patients with acute coronary syndrome (ACS), mainly because oral P2Y12 inhibitors are associated with delayed efficacy in patients with STEMI and because pre-treatment with P2Y12 inhibitors is discouraged in NSTE-ACS, and in patients with recent DES implantation and in need of urgent cardiac and non-cardiac surgery. More definitive evidence is needed, however, about optimal switching strategies between parenteral and oral P2Y12 inhibitors and about newer potent subcutaneous agents that are being developed for the pre-hospital setting.
Gradient blowup solutions of a semilinear parabolic equation with exponential source

In this paper, we consider the N-dimensional semilinear parabolic equation $ u_t=\Delta u+e^{|\nabla u|}$, for which the spatial derivative of solutions becomes unbounded in finite (or infinite) time while the solutions themselves remain bounded. We establish estimates of blowup rate as well as lower and upper bounds for the radial solutions. We prove that in this case the blowup rate does not match the one obtained by the rescaling method.
On the (non-)universality of the mixing length parameter

The success of the Böhm-Vitense formalism – the so-called mixing length theory – for the treatment of the energy transport in the superadiabatic stellar region in reproducing the properties of the Sun and other stars is well testified by the fact that it is commonly used in almost all stellar evolutionary codes. Yet, several results are pointing out against such an assumption. In this work, we address the universality of the mixing length parameter and search for a possible dependence on several global stellar parameters. While we observe a significant degree of correlation between the mixing length parameter and both the stellar mass and effective temperature. No such indication is found regarding the stellar activity, as stated by previous works.
Entrepreneurship on Social Networking Sites: The Roles of Attitude and Perceived Usefulness

Background: Social media platforms are a significant growth opportunity for enterprises, especially for microenterprises, due to the possibility of establishing direct contact with their customers. We investigate the psychological reasons that drive entrepreneurs towards the use of social networking sites (SNSs) for their business, following two important social psychology theories: the theory of planned behaviour and the technology acceptance model. We also tested for two personality traits: openness to experience and dominance. Methods: Data were acquired by examining 325 microentrepreneurs who decided to use either SNSs or traditional sales methods for their businesses. Results and conclusions: Our results confirm that of all the behavioural antecedents tested, perceived usefulness and attitude towards SNSs’ effect on business proved to be the best predictors of the intention to use (or continue using) SNSs for business activity. Implications and suggestions for future research are also discussed.
Modules Over Hereditary Noetherian Prime Rings, II

Let R be a hereditary noetherian prime ring ((hnp)-ring) with enough invertible ideals. Torsion modules over bounded (hnp)-rings were studied by the author in [10; 11]. All the results proved in [10; 11] also hold for torsion R-modules having no completely faithful submodules. In Section 2, indecomposable injective torsion R-modules which are not completely faithful are studied, and they are shown to have finite periodicities (Theorem (2.8) and Corollary (2.9)). These results are used to determine the structure of quasi-injective and quasi-projective modules over bounded (hnp)-rings (Theorems (2.13), (2.14) and (2.15)).
TUBERCULOSIS TRANSMISSION MODEL WITH CASE DETECTION AND TREATMENT

A deterministic tuberculosis model for theoretically assessing the potential impact of the combined effects of case detection in the presence of treatment is formulated. The qualitative features of its equilibria are analyzed and it is found that the disease-free equilibrium may not be globally asymptotically stable when the reproduction number is less than unity. This disease threshold number is further used to assess the impact of active TB case finding alone and in conjunction with treatment. A critical threshold parameter say for which case detection will have a positive impact is derived. Using the Centre Manifold theory, the model may exhibit the phenomenon of backward bifurcation (coexistence of a locally stable endemic equilibrium with a stable disease-free equilibrium) when the reproduction number is less than unity. It is shown that the possibility of backward bifurcation occurring decreases with increase case detection. Graphical representations suggest that increase in case finding accompanied by treatment of detected TB cases, result in a marked decrease of TB cases (both latent and active TB).
Longitudinal Radiographic Bone Density Measurement in Revision Hip Arthroplasty and Its Correlation with Clinical Outcome

The subjective analysis of conventional radiography represents the principal method for bone diagnostics in endoprosthetics. Alternative objective quantitative methods are described but not commonly used. Therefore, semi-quantitative methods are tested using digital computation and artificial intelligence to standardize, simplify, and ultimately improve the assessment. This study aimed to evaluate the correlation between relative density progressions and clinical outcomes. Radiographs and clinical examinations before and 24 and 48 weeks after surgery were obtained from sixty-eight patients with a modular hip stem. For the calculation of the relative bone density, the modal gray values of the Gruen zones were measured using ImageJ and were normalized by gray values of the highest and lowest ROI. The clinical outcomes were measured according to the Harris hip score before evaluating them for correlations. Analyses were performed separately for subgroups and bone regions. The Harris hip score increased from 44.15 ± 15.00 pre-operatively to 66.20 ± 13.87 at the latest follow-up. The relative bone density adjustment of Gruen zone 7 showed a significant correlation to its clinical outcome. Other bone adaptations could be realistically reproduced and differences by regional zones and patients’ histories visualized. Next to the simplicity and that no additional examination is required, the method provides good semi-quantitative results and visualizes adaptations, which make it suitable for use.
Static and LFN/RTN Local and Global Variability Analysis Using an Addressable Array Test Structure

The use of an addressable array test structure designed on a 28 nm FD-SOI technology for the variability analysis of static, low frequency noise (LFN) and Random Telegraph Noise (RTN) matching is presented. The experimental setup was validated, and a statistical analysis of the above electrical quantities is provided. Using such structures, combined with a switching matrix, local and global variability analysis can be performed while significantly increasing the number of samples, thus enabling a better description of the variations in LFN and RTN, especially when RTN signatures can be scarce. We show that local variations dominate the noise variability compared to global variations.