Miracle-dz/UniFAR-FTUs huggingface dataset:
Subclinical Epileptiform Dysfunction in Children with Idiopthic Autism

Background: Many studies reported high incidence of epileptiform discharges in children with autism, but with different rates and different patterns, few studies done for children with idiopathic autism. Aime of work: is to study the pattern of subclinical epileptiform discharge, and its clinical correlations for childern with idiopathic autism. Patients and methods: 47 children with idiopathic autism,with their ages range from 3-12 years (mean 6.96± 2.19), compared to 24 healthy age and sex matched contols. All children were assessed by electroencephalography (EEG) and brain imaging as a part of routine care, Childhood Autism Rating Scale (CARS) was done for assessing the severity of autism in patients group. Results: We found that,there were higher incidence of epileptiform discharges at children with idiopathic autism (51.1%) compared to 8.3% at the control group,(P value 0.002). The pattern of epileptiform abnormalities is highly correlated to the severity of autism (P value 0.000). Focal EEG changes (focal frontal ,occipital or temporal) predominate in severe cases of idiopathic autism (72.7%). In conclusion: subclinical epileptiform dysfunction were detected at higher rate in children with idiopathic autism, different EEG patterns were identified according to severity of autism. we recommend EEG study as a dignostic tool for children with idiopathic autism specially moderate and severe cases. [Riad M . Elsayed and Hala E. Sayyah. Subclinical Epileptiform Dysfunction in Children with Idiopthic Autism. J Am Sci 2012;8(8):398-401]. (ISSN: 1545-1003). http://www.jofamericanscience. org. 61
Machine Learning for Drug Design

—A common step in drug design is the formation of a quantitative structure-activity relationship (QSAR) to model an exploratory series of compounds. A QSAR generalizes how the structure of a compound relates to its biological activity. There is growing interest in the application of machine learning techniques in QSAR modeling research. However, no single technique can claim to be uniformly superior to any other. This study introduced the ensemble machine learning, a set of classifiers whose individual decisions are combined in some way (typically by weighted or unweighted voting) to improve the performance of the overall system. A comparative study was carried out of two popular ensemble learning algorithms, Bagging and AdaBoost, for QSAR modeling. Two test case problems were studied: the inhibition of Escherichia coli dihydrofolate reductase (DHFR) by pyrimidines, and the inhibition of rat/mouse tumor DHFR by triazines. It was observed that the ensemble learning algorithms, Bagging and AdaBoost, can significantly improve the performance of Decision Tree C4.5 and 1-R (p<0.05), while Naïve Bayesian and 1-Nearest Neighbor did not benefit from ensemble learning. Furthermore, in general, AdaBoost outperformed Bagging on the tested data sets.
Design of a Home Automation System Using Arduino

—This paper presents a low cost and flexible home control and environmental monitoring system. It employs an embedded micro – web server in Arduino Mega 2560 microcontroller, with IP connectivity for accessing and controlling devices and appliances remotely. These devices can be controlled through a web application or via Bluetooth Android based Smart phone app. The proposed system does not require a dedicated server PC with respect to similar systems and offers a novel communication protocol to monitor and control the home environment with more than just the switching functionality. To demonstrate the feasibility and effectiveness of this system, devices such as light switches, power plug, temperature sensor, gas sensor and motion sensors have been integrated with the proposed home control system.
The Effect of Adult Attachment Style on Couples Relationship Satisfaction

Background: There are different factors that contribute for the presence or absence of couple relationship satisfaction. However, very little is known about individual’s characteristics that bring into their relationships which influence couple’s relationship satisfaction. Adult attachment style is the one among these factors. Objective: The purpose of this study is to examine individual differences in relationship satisfaction using attachment theory as a framework. Methodology: A total of 306 (159 female and 147 male) participants were included from community sample. Three Kebeles in Yeka sub-city of Addis Ababa were selected randomly. Data were collected on relationship satisfaction and adult attachment. The constructs were measured by Relationship Assessment Scale (RAS, Hendrick, 1988) and Experience in Close Relationship Scale-Revised (ECR-R, Fraley et al., 2000). Pearson correlation and multiple regressions were run to check association and prediction among variables under study respectively. Result and Conclusion: The result confirmed that statistically significant correlation was found between/among most variables/constructs in the study. The standard regression revealed that both attachment dimensions (attachment anxiety and attachment avoidance) predicted relationship satisfaction. Participants who scored lower on both attachment dimensions reported higher relationship satisfaction. Implication: The research result has both theoretical and practical implications. Practically the study is beneficial for those policy makers and practitioners who work in the area of family (marriage) counseling and rights and well being of children.
The core of service quality philosophy lies on the premise that it can bring positive changes in quality-oriented management practices towards enhancing customer satisfaction as well as improving customer loyalty. Theoretically, the retail company must analyse

The purpose of this paper is to examine the importance of incorporating service quality in the Malaysian hypermarket industry. Service quality dimensions investigated in this paper consist of several important determinants namely tangible, reliability, responsiveness, competency, courtesy and credibility. The study measures customers’ perceptions of service quality offered, level of customer satisfaction and loyalty perceived from their experiences shopping in the hypermarkets. The paper specifically investigates the importance of service quality on customer loyalty mediated by customer satisfaction. In addition, the study also tries to discover whether location (strategically) plays a significant moderating role in the linkage between customer satisfaction and customer loyalty. Empirical associations in this study are analyzed through inferential statistical methods such as Pearson’s correlation, hierarchical regression and regression-based mediation analyses. The findings suggest that service quality has significant correlations with both customer satisfaction and customer loyalty. The result also provides evidence that customer satisfaction fully mediates the linkages between tangible, courtesy and credibility and customer loyalty. In addition, location (from strategic perspective) significantly moderates the linkage between customer satisfaction and customer loyalty. Therefore, it is suggested that a more strategic location of a hypermarket can strengthen the relationship between customer satisfaction and customer loyalty and in the long run will benefit the retail business. The findings of the study provide striking demonstrations of the importance of service quality in enhancing customer satisfaction and customer loyalty of Malaysian hypermarkets. The result indicates that Malaysian hypermarkets should emphasise greater attention to dimensions such as tangibles, courtesy and credibility of service quality dimensions and a greater degree of hypermarket management support for service quality enhancement initiatives.
Mesenchymal Stem Cell (MSC) Transplantation in Patients with Amyotrophic Lateral Sclerosis (ALS): Is there a “Responder Population”?

Objective: To analyze the safety and clinical effect of stem cell therapy in ALS. Methods: In phase I of the trial, ALS subjects have been intrathecally transplanted with autologous bone marrowderived mesenchymal stem cells (MSCs) using a surgical procedure. Results: We present the results of a 6-month interim analysis of the ongoing study. Intrathecal administration of MSCs into ALS patients was feasible and safe. We showed a clinical benefit evident for the entire group of patients (n=25). The mean rate of ALSFRS-R score change (decrease) pre-transplant was 1.76 ± 1.36 points/period whereas the mean post-transplant rate was 1.06 ± 0.9 points/period (p=0.014). The key finding of our study is that there appears to be a group of patients, whom we call “responders” whose reaction to the treatment was different from the reaction of other patients we call “nonresponders”. Conclusion: In our study the “responders” progressed faster prior to the treatment than “non-responders”. Hence, we hypothesize that the pre-treatment progression rate may play a role as a predictive factor and a criterion for selecting ALS patients for cell-based therapies.
Fetal Origin of Adult Cardiometabolic Diseases: Micronutrient and microRNA Interventions

President Barack Obama in his State of the Union Address on January 30, 2015, launched a program called “Personal Medicine”. In his lecture to the nation, he said, “Doctors have always recognized that every patient is unique, and doctors have always tried to tailor their treatments as best they can to individuals. You can match a blood transfusion to a blood type, that was an important discovery. What if matching a cancer cure to our genetic code was as easy, just as standard? What if figuring out the right dose of medicine was as simple as taking our temperature? ” These are very important questions, begging for appropriate answers. With such thoughts in mind, Scientists in Bengaluru, India, organized a conference recently, called Genomics-2019, aimed at discussing the role of this emerging science and technology, transforming the lives with Genomics. I was invited to present a key note lecture, and I selected the topic of “Fetal Origin of Adult Diseases: From Micronutrients to Micro RNAs”, a topic that is very dear to my heart. CSI Holdsworth Mission Hospital (HMH), Mysore, India, has kept meticulous records of newborn babies, in this institution since 1934. Collective studies from this institution and other centers in India, as well as by the UK epidemiology group, have demonstrated, that children born with low birth-weight are ‘at risk’, for the development of cardiometabolic diseases in their later life. Based on these and other similar studies Professor David Barker, a British Epidemiologist suggested a hypothesis,‘Barker Hypothesis’ to explain, Fetal Origin of Adult Diseases (FOAD)”. This hypothesis states, that intrauterine growth retardation, low birth weight, and premature birth, have a causal relationship to the origins of hypertension, coronary artery disease, and non-insulin dependent diabetes, in middle age. After almost three decades, studies from Children’s National Hospital (CNH), Washington DC, has demonstrated, that adipocyte-derived exosomal RNAs (miRNAs), may serve as ‘biological tweets’ and thus may be a game changer for detecting adiposity/obesity-related disorders. Thus, a new hypothesis may be in the offing, to explain the fetal origins of adult cardiometabolic diseases. In this overview, we discuss both the old hypothesis, and the new hypothesis for the FOAD, and present our view points on possible intervention strategies for using micronutrient supplements, as well as micro RNAs as therapeutics.
Compact Implementation of SHA3-1024 on FPGA

SHA3 algorithm had proposed by five people with five different approaches. In that NIST (National Institute of Standards and Technology) selected one approach . that approach proposed by Keccak . after that Keccak sha3 algorithm using with memories but it will take more area so in our paper we are designing 128 bit Keccak sequential architecture . sha3 having different variants like sha224,sha256,sha512,sha1024.we are implementing sha1024 variant using Xilinx 13.2.
Response rate and bridging to hematopoietic stem cell transplantation (HSCT) with quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory AML after second-line chemotherapy or previous bone marrow transplant.

7012 Background: FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) in acute myeloid leukemia (AML) is associated with early relapse after chemotherapy and poor survival. Relapse after HSCT or failure of salvage chemotherapy in FLT3-ITD AML is rarely associated with subsequent HSCT or durable survival. Quizartinib, an oral FLT3 inhibitor, shows promising activity; a Ph 2 study (n=333) of quizartinib monotherapy (Levis et al, ASH 2012) reported that quizartinib often bridged patients (pts) to HSCT. Methods: 136 FLT3-ITD(+) and 40 FLT3-ITD(-) pts, relapsed/refractory after HSCT or 1-second line regimen, were included. The response category of composite complete remission (CRc) comprised complete remission [CR] + complete remission with incomplete platelet recovery [CRp] + complete remission with incomplete hematologic recovery [CRi]. Results: Quizartinib was discontinued for HSCT in 47/136 FLT3-ITD(+) pts (35%), with 44/47 having at least a PR (2 CRp, 24 CRi, 18 PR). Median overall survival (.
Regeneration of Traumatic Tympanic Membrane Perforations

Objectives/Hypothesis: To analyse the therapeutic strategies for treating traumatic tympanic membrane perforations (TTMPs). Study Design: Literature review Methods: The relevant literature on methods for treating human TTMPs was reviewed. The advantages and disadvantages of each treatment were analysed. Results: A total of 24 articles were included. Among them, eight reported the efficacy of growth factors, eight considered patches, and five only observed spontaneous healing. The remaining three studies focused on other treatment methods. Conclusion: Although 80% of TTMPs tend to spontaneously heal within 3 months, large perforations usually fail to close. Topical application of growth factors or ofloxacin ear drops is simple, convenient, and inexpensive, and it can accelerate the healing of the eardrum and improve the closure rate of large TTMPs.
Large Goiters Surgery and Intubation Conditions. Case Series from the Eastern Provinces of the Democratic Republic of Congo

Background: Airway management may be challenging in patients with large goiter especially in a limited resource environment. Objectives: To investigate if the presence of benign large goiters increases the risk of difficult intubation. The work was done in the Eastern provinces of the Democratic Republic of Congo. Methods: One hundred forty-seven patients scheduled for subtotal thyroidectomy were included. Experienced anaesthesiologists performed all intubations and scored the difficulties (Cormack-Lehane) and number of laryngoscopies. Results: We analyzed 136 females and 11 males [mean (SD) age 45.5 (10.4) years, weight 60.8 (12.1) kg, height 157.8 (7.5) cm] patients. Ninety-three were Mallampati class I, 39 class II, 13 class III, and 2 class IV. Mouth opening was >3.5cm in 141 cases and <3.5cm in 6 cases. The mean (SD) neck circumference was of 36.3 (2.9) cm. Dyspnea was present in 54 and dysphagia in 44 of patients. Clinical tracheal deviation was observed in 53 and a tracheal compression in 26 cases. One hundred thirtythree patients presented Cormack-Lehane grade I, 11 grade II, 2 grade III and 1 grade IV. In 133 cases tracheal intubation was achieved on first attempt, two were needed in 11 cases and up to four in 3 cases. No failed intubation was encountered. No correlation was found between goiter characteristics or Cormack-Lehane and number of laryngoscopies. Conclusion: A large goiter was not associated with an increased incidence of difficult laryngoscopy or intubation. Thus, no particular measures should be taken even in regard to a limited resource environment.
Study of Lipid Profile in Patients with Chronic Kidney Disease on Conservative Management and Hemodialysis

Background: Chronic renal failure results in profound lipid disorders which stem largely from the deregulation of high-density lipoproteins (HDL) and triglyceride-rich lipoprotein metabolism which increases the risk of arteriosclerotic cardiovascular disease which is the leading cause of mortality among chronic kidney disease (CKD) patients. Materials and Methods: This is a cross-sectional observational study conducted after ethical committee approval about lipid profile on CKD patients on conservative management and hemodialysis compared with normal healthy controls at our hospital and movement for global mental health between June 2015 and June 2016, after considering inclusion and exclusion criteria. Lipid profile was collected from eligible patients and controls. Results: There were a statistically significant decrease in HDL and increase in thyroglobulin, low-density lipoprotein (LDL), and total cholesterol levels when compared with normal healthy controls. There was a negative correlation between serum creatinine and HDL levels. Among CKD patients, there was a significant decrease in HDL and increase in LDL level in both conservative and hemodialysis groups. Conclusion: Treatment of dyslipidemia helps to decrease mortality in CKD patients.
Effects of Nebivolol Therapy on Angina, Health Related Quality of Life, and Cardiopulmonary Function in Women with Microvascular Angina

Introduction Although women have less obstructive coronary artery disease (CAD) then men, women continue to have a greater burden of symptoms, more ischemia and a higher rate of adverse outcomes compared to age-matched male counterparts [1]. This has led to the recognition of microvascular angina (MVA) as an alternative to the flow limiting atherosclerotic CAD mechanism [2]. Identifying effective therapeutic agents to improve the morbidity and mortality of women suffering from MVA remains a priority. Nebivolol has antioxidant and vasodilator properties via its effect on nitric oxide bioactivity. Its subsequent endothelial effects make it a potential therapeutic agent for MVA [3]. The aim of this study was to investigate the effects of nebivolol on angina, the healthrelated quality of life, and cardiopulmonary function of women with MVA.
Embryonic deve lopment o f nudibranch spec ie s ( Mol lu sca : Opisthobranchia ) in the Gulf of Thailand

*Corresponding author: Shettapong Meksumpun, Department of Marine Science, Faculty of Fisheries, Kasetsart University, Bangkok 10900, Thailand. Tel: 6625797610 Fax: 6625614287 E-mail: ffisspm@ku.ac. th Foundation Project: Partly funded by the Center of Advanced Studies in Tropical Natural Resources, KU Institute for Advanced Studies, Kasetsart University and Faculty of Technology, Mahasarakham University.
Renegotiating power in adult safeguarding: the role of advocacy

The increased involvement of adults at risk in the safeguarding process has become a prominent issue within English safeguarding policy. However, there is evidence to suggest that actual levels of involvement are still low. The purpose of this paper is to present findings from a PhD study in relation to the benefits of advocacy in supporting this involvement in adult safeguarding for older people. ,Participants in the study included advocates and social workers who had experience of working with older people through the safeguarding process within two North East England local authorities. A critical realist approach through in-depth interviews was taken with all the participants. ,The research findings in relation to the benefits of advocacy in supporting older people going through safeguarding processes are reported. The practical limitations and factors which help and hinder advocacy support within the process are also considered. The theoretical implications for power, empowerment, and advocacy are also explored. ,A key limitation of this research is that it did not include older people who had been through safeguarding amongst the participants. ,Key implications for practice and policy are discussed. ,The paper provides an overview and critique of empowerment in adult safeguarding and the role that advocates play in promoting this key principle.
TOP MANAGEMENT TEAM DIVERSITY, THE STRATEGIC ISOMORPHISM AND FIRMS’ PERFORMANCE: A STUDY IN THE INDONESIAN

This study aimed at examining the influence of Top Management Teams’ (TMT) diversity on the strategic isomorphism and tested its impact on firms’ performance. Using upper echelons theory that concerned to the role of TMT in company and institutional theory that discussed the institutional forces that affect company’s performance as framework, this study tried to see how the role of the TMTs’ diversity in demographic characteristics determined their firm's strategy in dealing with institutional pressures to achieve good performance. This study uses data from listed Indonesian banks and it is analyzed by using hierarchical regression analysis method. The analysis found that several TMT diversity variables affected the strategic isomorphism and firms’ performance. The research also confirmed that the strategic isomorphism affected a firm's performance. Several implications were discussed.
Quality Characteristics of Whole Guinea Fowl Egg as Binder in Beef and Chevon Burgers. J. World Poult. Res., 6 (2): 66-72

Frederick Adzitey*, Peter Birteeb and Benjamin Kwasi Holdbrook Department of Animal Science, Faculty of Agriculture, University for Development studies, P.O. Box TL 1882, Tamale, Ghana *Corresponding author's Email: adzitey@yahoo.co.uk Received: 06 May, 2016 Accepted: 08 June, 2016 ABSTRACT This study was conducted to determine the cohesiveness of whole guinea fowl egg as a binder in chevon and beef burgers. The study also investigated the sensory characteristics, nutritional content, cooking loss, lateral shrinkage, welling and doming of the beef and chevon burgers prepared using whole guinea fowl eggs. A total of 3 kg beef and 3 kg chevon were used. The meats were assigned using complete randomized design into 3 levels. The 3 levels of inclusion of the whole guinea fowl egg per kilogram of meat were 0 g, 50 g and 100 g which corresponds to each treatment that is B1 (control), B2 (5 %) and B3 (9 %) for beef, and C1 (control), C2 (5 %) and C3 (9 %) for chevon, respectively. Thus each treatment contained 1 kg meat, 0.5 g red pepper, 1.0 g black pepper, 1.0 g white pepper, 2.0 g mixed spice (adobo®), 5 g salt and whole guinea fowl egg (0 g, 50 g or 100 g). The meat and spices were minced and moulded manually into burgers using a cylindrical tube to obtain uniform shapes and sizes. They were vacuumpacked in transparent packaging bags and stored overnight at 4 °C prior to processing. The processed samples were evaluated for their sensory, nutritional and binding properties. Sensory characteristics of beef and chevon burgers (cohesiveness, colour, juiciness, texture, taste, flavor and overall liking) showed no significant differences (P > 0.05). In absolute terms beef and chevon burgers with the highest inclusion level (9 %) of whole guinea fowl egg were most preferred. There were also no significant differences (P > 0.05) in moisture content, crude protein content, pH, cooking loss, lateral shrinkage and doming of the beef and chevon burgers. Significant difference (P < 0.05) occurred in the crude fat content of chevon burger but not beef burger. Welling was not observed in the beef and chevon burgers.