Miracle-dz/UniFAR-FTUs huggingface dataset:
In Vitro Platform Establishes Antigen-Specific CD8+ T Cell Cytotoxicity to Encapsulated Cells via Indirect Antigen Recognition

Cell replacement therapy has the potential to cure diseases caused by the absence or malfunction of specialized cells. A substantial impediment to the success of any non-autologous cellular transplant is the need for systemic immunosuppressive drugs to prevent host-mediated rejection of the foreign cells. Cellular encapsulation, i.e., the entrapment of cells within stable polymeric hydrogels, has been clinically explored to prevent host immune recognition and attack, but the efficacy of these encapsulated grafts is poor. While several studies have explored improvements in innate immune acceptance of these encapsulated cells, little attention has been paid to the roles of adaptive immune responses, specifically graft-targeting T cell activation, in graft destabilization. Herein, we established an efficient, single-antigen in vitro platform capable of delineating direct and indirect host T cell recognition to microencapsulated cellular grafts and evaluating their consequential impacts. Using alginate as the model hydrogel, encapsulated membrane-bound ovalbumin (mOVA) stimulator cells were incubated with antigen-specific OTI lymphocytes and subsequent OVA-specific CD8+ T cell activation and effector function were quantified. We established that alginate microencapsulation abrogates direct T cell activation by interrupting donor-host interaction; however, indirect T cell activation mediated by host antigen presenting cells (APCs) primed with shed donor antigens still occurs. These activated T cells imparted cytotoxicity on the encapsulated cells, likely via diffusion of cytotoxic solutes. Overall, this platform delivers unique mechanistic insight into the impacts of hydrogel encapsulation on host adaptive immune responses, as well as a tool for the efficient immune screening on new encapsulation methods and/or synergistic immunomodulatory agents.
Maternal mortality in a tertiary care centre in North India: a retrospective study

Maternal mortality is defined as the death of any woman while being pregnant or within 42 completed days of termination of pregnancy, irrespective of the duration or site of pregnancy, from any cause related to or aggravated by pregnancy, but not from accidental or incidental causes. Maternal mortality is defined, as maternal death rate per 1,00,000 live births. 1 The World Health Organization (WHO) estimates that, of 536,000 maternal deaths occurring globally each year, 136,000 take place in India. Estimates of the global burden of disease for 1990 also showed that India contributed 25% to disability-adjusted life-years lost due to maternal conditions alone.
The Correlation between Pre-service Teachers’ Attitudes towards Technology and Achievement in Material Design Course

Abstract This study aims to specify the correlation between pre-service teachers’ attitudes towards technology and achievement in material design. The participants of the study consisted of 127 pre-service teachers from different disciplines. To determine the attitudes of pre-service teachers, data was collected using the “Technology Attitude Scale”. The achievement scores of pre-service teachers in material design were obtained using the material evaluation form developed by the researchers based on the principles of designing material. While evaluating the data, analyses of Pearson correlation and t-test were conducted, the results revealed a positive correlation between pre-service teachers’ attitudes towards technology and achievement in material design. Also, significant differences were found according to pre-service teachers’ disciplines. These findings and implications for educational researchers were also further discussed.
ANALYSIS OF THE EFFECT OF LEADERSHIP AND ORGANIZATIONAL CULTURE ON ORGANIZATIONAL CITIZENSHIP BEHAVIOR WITH JOB SATISFACTION AS AN INTERVENING VARIABLE AT UBUD WANA RESORT, GIANYAR

This study has several objectives. First, to determine the influence of leadership and organizational culture partially on organizational citizenship behavior at Ubud Wana Resort. Second, to find out the influence of leadership and organizational culture partially on job satisfaction at Ubud Wana Resort. Third, to determine the effect of job satisfaction on organizational citizenship behavior at Ubud Wana Resort, and Fourth, to determine the influence of leadership and organizational culture partially on organizational citizenship behavior with job satisfaction as an intervening variable at Ubud Wana Resort. This research is included in causal associative research using a quantitative approach. Quantitative approaches are used because the data used to analyze relationships between variables is expressed by numbers. This study connects the influence of Leadership, Organizational Culture and Job Satisfaction on Organizational Citizenship Behavior. The result of this study are Leadership has a positive and significant effect partially on organizational citizenship behavior, Organizational culture has a positive and significant effect partially on organizational citizenship, Leadership has a positive and significant partial effect on job satisfaction, Organizational culture has a partial and positive influence on job satisfaction, Job satisfaction has a significant influence on organizational citizenship behavior, Leadership influences OCB through Job Satisfaction" is not proven, and Organizational Culture influences OCB through Job Satisfaction" is not proven
Teamwork and Entrepreneurial Behavior among K-12 Teachers in the United States

Abstract This study attempted to identify the predictors of entrepreneurial behavior by assessing a series of variables that included teamwork skills and demographic variables, and to explore teachers’ experiences with teamwork. A sample of 367 K-12 public school teachers completed the survey. The findings indicated that teamwork predicts entrepreneurial behavior. Most participants received teamwork training through their school districts. Barriers to teamwork included time constraints, individual differences, and inability to collaborate.
The Effects of Destination Brand Personality on Chinese tourists' Revisit Intention to Glasgow: An Examination across Gender

Abstract The aim of this research is to examine the mediating effects of self-congruity between destination brand personality, to revisit intention and heed the moderating effects of gender between self-congruity. Therefore, data were collected through a survey from 226 Chinese outbound tourists in Glasgow city, United Kingdom and was analyzed to provide evidence. Based on the results, the analysis of partial least squares structural equation modeling (PLS-SEM) using the Smart PLS 3.0 program indicated that self-congruity was mediated partially through destination brand personality and revisit intention. In tourism destination, Aaker five dimension of brand personality model was particularly adapted into practice. However, the model failed to perform an actual self-congruity to mediate all five dimensions (i.e., sincerity, excitement, competence, excitement, sophistication and ruggedness) of destination brand personality and revisit intention. The results revealed that the ideal self-congruity is a mediating effect between destination brand personality (i.e., sincerity and excitement) and revisit intention. Moreover, this study also reported that the moderating role of gender has no effects on self-congruity and revisit intention. No difference was observed between female and male Chinese tourists who rely more on destination brand personality over self-congruity when the impact of symbolic destination brand benefits on their intention to revisit Glasgow was considered. Findings further offer specific implications for both theoretical insight and marketing practice in context of tourism destinations in Glasgow.
Measuring Outcomes in Competence and Confidence in Clinical Skills Through the Use of Standardized Patients

MEASURING OUTCOMES IN COMPETENCE AND CONFIDENCE IN CLINICAL SKILLS THROUGH THE USE OF STANDARDIZED PATIENTS Jennifer W. Cuchna Old Dominion University, 2017 Director: Dr. Bonnie L. Van Lunen Limited literature is available concerning the use of standardized patients (SPs) in physical therapy education related to outcomes which are assessed. The purpose of our study was to investigate the effects SP implementation had on first year, doctor of physical therapy (DPT) student’s communication and patient interviewing skills and their confidence in those skills. Our study utilized a comparison group, repeated measures design with the collection of four survey instruments at pre-test and two posttest time points. The instruments for our study measured general self-efficacy (GSE), task-specific self-efficacy (Self-Perceived Communication Competence (SPCC) and Froehlich Communication Competence (FroCom) and confidence (Standardized Patient Learning Outcomes Assessment Tool for Confidence (SPLOAT). Both groups completed the survey instrument packet at all three time points, however, only the experimental group received SP encounters prior to the second and final instrument collections. General linear model repeated measures analysis was utilized and the results indicated baseline differences for the GSE, SPCC and FroCom with the experimental group having higher average scores, thus making comparisons of the groups for these measures less meaningful. Significant improvements in average overall confidence scores (SPLOAT) were evident at each collection time point for the experimental group with significant main effects for time and group. Additionally, there was a significant interaction effect between time and group indicating the experimental group increased in their average overall scores ranging from moderate to substantial for all time points. The experimental group performed significantly higher on the second SP encounter compared to the first. The comparison group received no SP encounters throughout the entire study, however also showed significant increases in average overall scores from the pre-test to posttest1 collections but did not indicate significance at the pre-test to posttest2 or for the posttest1 to posttest2 collections. The increases seen in both groups could be attributed to normal maturation through the curriculum and experience over time. SPLOAT score increases were evident in both groups, however only initially for the comparison group. The SP use of the experimental group supports previous research suggesting that multiple exposures to simulation activities, such as SP, aids in the confidence improvements.
Crowdfunding in a Competitive Environment

Crowdfunding has mostly been used to finance very unique projects. Recently, however, companies have begun using it to finance more traditional products where they compete against other sellers of similar products. Major crowdfunding platforms, Kickstarter and Indiegogo, as well as Amazon have launched several projects consistent with this trend. This paper offers a model where two competing firms can use crowdfunding prior to direct sales. The model provides several implications that have not yet been tested e.g., (1) Firms can use crowdfunding strategically to signal a high level of demand for their products; (2) (Reward-based) crowdfunding is procyclical; (3) A higher platform fee may lead to higher firm profits in equilibrium; (4) Competition increases the chances of using crowdfunding compared to the monopoly case; (5) A non-monotonic relationship exists between the risk of crowdfunding campaign failure and firm profit.
THE EFFECT OF ABDOMINAL STRETCHING EXERCISE ON DYSMENORRHEA IN ADOLESCENT GIRLS

Based on my survey in February 2018 at the three SMA Negeri Cimahi, 956 adolescent girls (67.2%) from 1.422 of female students had experienced dysmenorrhea. Dysmenorrhea is disturbed young women’s study activities at school. The preliminary study found that 10 teenagers had dysmenorrhea, 4 of them said they could not follow the sporting activities. This research aimed to determine the effect of abdominal stretching exercise in reducing the pain due to dysmenorrhea in the adolescent girls. The method used a quasi-experiment design with one group pretest-posttest. The population in this study was 174 peoples and obtained 19 samples with random sampling technique. Pain score measured by the Verbal Descriptor Scale before and after given the abdominal stretching exercises for 15 minutes, 3 times during 7 days with an interval of one day. Data analysis used univariate test and t-dependent test. The results of the study obtained the pain score before the abdominal stretching exercises were 6.16 scale (moderate pain) and after abdominal stretching exercises was 2.37 scale (mild pain) with pain scale difference 3.79. T-dependent statistical test obtained that p-value < 0,001, it refers to abdominal stretching exercises affects in decreasing pain scale of dysmenorrhea. Abdominal stretching exercises are recommended as an influential intervention of dysmenorrhea for adolescent girls. This exercises can be a new routine activity for adolescent girls since it is very beneficial for them.Keywords: Abdominal stretching, adolescent girls, dysmenorrhea, exercises.
Safeguarding Deaf Children: A Multi-agency Focus on Actions for Change

This article concerns safeguarding deaf children and is written by a dedicated multidisciplinary consortium of national organisations, service providers and academics in the UK. Data are derived from 81 senior managers in social care, health, education, the police and voluntary sector organisations who attended a specialist conference concerning deaf children and safeguarding and who participated in three structured workshops. Thematic content analyses revealed their perspectives on risks and barriers to safeguarding deaf children at practice and organisational levels. An impact/effort matrix structure was used to elicit from participants a series of actions to improve practice and these were thematically organised. Findings are discussed in the context of the 2018 revisions to ‘Working Together’ in England, statutory reforms to PHSE in schools in England and recent NICE revised guidance on Child Maltreatment. Implications for practice are highlighted.
The Impact of Socio-cultural Factors in Qatar on Females in Engineering

This paper provides a detailed insight into the Arab culture, specifically, the perceptions of Qatari culture on women in engineering. The Qatari culture greatly discourage and limit females from entering engineering fields, which is mainly due to Qatari’s culture mentality. In addition, this paper will show how the socio-cultural factors in Qatar plays a main role in hindering females from pursuing engineering. The three main factors are gender roles, female education, female in mixed workplace. These factors unfortunately depriving women from their rights of independence, education, and choice of career.
AN ANALYSIS OF TEACHER’S QUESTIONING STRATEGIES IN ENGLISH CLASSROOM : A CASE STUDY AT SMK NEGERI 4 MEDAN

The research was about An Analysis of Teacher ’s Questioning Strategies in English Classroom : A Case Study at SMK Negeri 4 Medan. The aim s of the research were to describe the types of questions commonly used by the teacher and to analyze the function of using the questions. The method of the research was descriptive qualitative method. The data were obtained by videotaping the classroom interaction between teacher and students in English Class The result of the study revealed that there were two types of questions commonly used by the teacherin the class; they were display and referential questions. The total percentage of display question was 74 % and referential questions was 26 %. The function s of the questions were to arouse interest and curiosity concerning a topic, to focus attention on a particular issue or aspect , to develop an active approach to learning, to stimulate students to ask questions to teachers and other student s, to check learner’s understanding, to elicit information and to control the classroom. Keywords: Teacher, Questioning Strategy ,Referential Question, Display Questions, English Classroom
Nuclear upregulation of PI3K p110β correlates with increased rRNA transcription in endometrial cancer cells

Genes encoding for components of the phosphoinositide 3-kinase (PI3K) pathway are frequently mutated in cancer, including inactivating mutations of PTEN and activating mutations of PIK3CA, encoding the PI3K catalytic subunit p110α. PIK3CB, encoding p110β, is rarely mutated, but can contribute to tumourigenesis in some PTEN-deficient tumours. The underlying molecular mechanisms are however poorly understood. By analysing cell lines and annotated clinical samples, we have previously found that p110β is highly expressed in endometrial cancer (EC) cell lines and that PIK3CB mRNA levels increase early in primary tumours correlating with lower survival. Selective inhibition of p110α and p110β led to different effects on cell signalling and cell function, p110α activity being correlated to cell survival in PIK3CA mutant cells and p110β with cell proliferation in PTEN-deficient cells. To understand the mechanisms governing the differential roles of these isoforms, we assessed their sub-cellular localisation. p110α was cytoplasmic whereas p110β was both cytoplasmic and nuclear with increased levels in both compartments in cancer cells. Immunohistochemistry of p110β in clinically annotated patient tumour sections revealed high nuclear/cytoplasmic staining ratio, which correlated significantly with higher grades. Consistently, the presence of high levels of p110β in the nuclei of EC cells, correlated with high levels of its product phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) in the nucleus. Using immunofluorescence labelling, we observed both p110β and PtdIns(3,4,5)P3 in the nucleoli of EC cell lines. The production of nucleolar PtdIns(3,4,5)P3 was dependent upon p110β activity. EC cells with high levels of nuclear PtdIns(3,4,5)P3 and p110β showed elevated nucleolar activity as assessed by the increase in 47S pre-rRNA transcriptional levels in a p110β-dependent manner. Altogether, these results present a nucleolar role for the PI3K pathway that may contribute to tumour progression in endometrial cancer.
LONGITUDINAL DESCRIPTIVE PROFILE OF COLLEGIATE PITCHERS PARTICIPATING IN A SUMMER BASEBALL LEAGUE

OF THESIS LONGITUDINAL DESCRIPTIVE PROFILE OF COLLEGIATE PITCHERS PARTICIPATING IN A SUMMER BASEBALL LEAGUE The purpose of this study was to provide a longitudinal profile of pitching performance in a cohort of pitchers over two collegiate seasons and a summer league. Thus, this study utilized a longitudinal design to evaluate the impact of summer league participation on subsequent collegiate regular season pitching performance. Specifically, the performance of a cohort of Division 1 collegiate baseball pitchers during the 2018 Spring collegiate season, 2018 Summer League season, and the 2019 Spring collegiate season was evaluated and stratified by pitcher designation, arm dominance, and academic status. Analyses of variance were used to identify main and interaction effects on pitching outcomes. The level of statistical significance was set at p < . 05 for all analyses. Data were publicly accessed from thirty-seven Division I collegiate baseball pitchers who participated in a summer baseball league. Collectively, all pitchers significantly improved earned run average (p = .024), number of strikeouts (p = .011), and strikeout efficiency (p = .034) from 2018 to 2019 collegiate seasons. Whereas, starting pitchers (n = 15) yielded fewer earned runs (p = .039) and enhanced hit efficiency (p = .012) from 2018 to 2019 collegiate seasons. Relief pitchers (n = 16) produced significantly more strikeouts from 2018 to 2019 collegiate seasons (p = .012). Finally, there were no differences in pitching outcomes for closers (n = 6) over time (p > .05). Regarding arm dominance, right-handed pitchers (n = 23) improved win average (p = .001), strikeouts (p = .008) and strikeout efficiency (p = .031) from 2018 to 2019 collegiate seasons. Left-handed pitchers (n = 14) significantly improved earned run average (p = .015), earned runs (p = .048), and hit efficiency (p = .014). Regarding academic stratification, the freshman to sophomore cohort (n = 15) significantly improved number of pitches (p = .018), innings pitched (p = .019), hits (p = .029), and strikeouts (p = .003). Whereas, the sophomore to junior cohort (n = 21) significantly improved losses (p = .042) and hit efficiency (p =.028). The findings from this study indicate that participation in a summer baseball league may have improved several critical pitching metrics with implications to enhance team performance.
Palliative Home Care and Chinese Immigrants: The Meanings of Home and Negotiations of Care

Palliative care for non-dominant ethnocultural groups is problematized in the palliative care literature, which often presents essentialist conceptions of cultural beliefs on death and dying. Death is often portrayed as a taboo topic within the Chinese community, and thus, the assumption is that dying at home may not be the preferred option. Beyond these stereotypical representations, little is known about what it is like for Chinese immigrants with terminal cancer to receive palliative home care. Home is a complex site where cultural “difference” becomes contextually salient when home care providers introduce palliative care. More is potentially at stake than the violation of a taboo, as Chinese immigrant care recipients, their family caregivers, and home care providers negotiate changes to the existing routines of the home. The purpose of this study was to examine how meanings of home condition negotiations of care between Chinese immigrants with terminal cancer receiving palliative home care, family caregivers, and home care providers. Postcolonial theory provided a critical lens for this focused ethnographic study of palliative home care for Chinese Canadian immigrants. The analysis drew on postcolonial concepts such as Othering, subjugation, and hybridity. The methods included
The construction of collective competencies in the dynamics of budgetary routines

Resumo A crescente difusão de configurações coletivas de trabalho no atual ambiente organizacional não tem apresentado contrapartida na produção científica sobre o tema (BOREHAM, 2011). Paradoxalmente, porém, alguns campos do debate sobre organizações destacam o papel dos coletivos de trabalho, como é o caso da literatura sobre Rotinas Organizacionais - RO - (NELSON e WINTER, 2005; PENTLAND e FELDMAN, 2005). A questão que mobiliza esta investigação explora a relação entre esses dois temas: a dinâmica das rotinas orçamentárias corporativas pode constituir um espaço adequado para a formação e o desenvolvimento de competências coletivas? O objetivo é examinar a elaboração de orçamentos corporativos, com base na abordagem de rotina organizacional, a fim de identificar evidências de coletivos de trabalho e da formação de atributos e competências coletivas. Essas respostas transitam por uma investigação qualitativa e fenomenográfica que apontou quatro categorias descritivas da configuração coletiva do trabalho: Comprometimento com a Entrega, Reconfiguração das Rotinas, Disponibilização Compartilhada e Construção de Redes de Relacionamento. De entre as contribuições da pesquisa, destaque para: o potencial da teoria das RO como referência a análise de processos corporativos; identificação de processos capazes de contribuir na gestão de coletivos de trabalho; e o emprego do método fenomenográfico como alternativa para apropriar fenômenos organizacionais de natureza pouco tangíveis.