Miracle-dz/UniFAR-FTUs huggingface dataset:
The Accuracy of Cytology, Colposcopy and Pathology in Evaluating Precancerous Cervical Lesions

Abstract Introduction: Cervical cancer (CC) is the third most common cancer in the world, and Romania has the highest incidence of cervical cancer in Europe. The aim of this study was to evaluate the correlation between cytology, colposcopy, and pathology for the early detection of premalignant cervical lesions in a group of Romanian patients. Methods: This observational type 2 cohort study included 128 women from our unit, “Bucur” Maternity, who were referred for cervical cancer screening. Age, clinical diagnosis, cytology results, colposcopy impression, and biopsy results were considered. Colposcopy was performed by two experienced examiners. The pathological examination was performed by an experienced pathologist. Results: The cytology found high-grade squamous intraepithelial lesions in 60.9% of patients, low-grade squamous intraepithelial lesions in 28.1%, atypical squamous cells for which a high-grade lesion could not be excluded in 9.4%, and atypical squamous cells of undetermined significance, known as repeated LSIL, in 1.6%. The first evaluator identified low-grade lesions in 56.3%, high-grade lesions in 40.6%, and invasion in 3.1% of patients. The second evaluator identified low-grade lesions in 59.4%, high-grade lesions in 32.0%, and invasion in 8.6% of patients. The pathological exam identified low-grade lesions in 64.1%, high-grade lesions in 25%, and carcinoma in 14% of patients. The colposcopic accuracy was greater than the cytologic accuracy. Conclusions: Colposcopy remains an essential tool for the identification of cervical premalignant cancer cells. Standardization of the protocol provided an insignificant interobserver variability and can serve as support for further postgraduate teaching.
Comparison of the Modulating Effect of Anthocyanin-Rich Sour Cherry Extract on Occludin and ZO-1 on Caco-2 and HUVEC Cultures

Increased permeability of the epithelial and endothelial cell layers results in the onset of pathogenic mechanisms. In both cell types, cell–cell connections play a regulatory role in altering membrane permeability. The aim of this study was to investigate the modulating effect of anthocyanin-rich extract (AC) on TJ proteins in inflammatory Caco-2 and HUVEC monolayers. Distribution of Occludin and zonula occludens-1 (ZO-1) were investigated by immunohistochemical staining and the protein levels were measured by flow cytometry. The mRNA expression was determined by quantitative real-time PCR. The transepithelial electrical resistance (TEER) values were measured during a permeability assay on HUVEC cell culture. As a result of inflammatory induction by TNF-α, redistribution of proteins was observed in Caco-2 cell culture, which was reduced by AC treatment. In HUVEC cell culture, the decrease in protein and mRNA expression was more dominant during inflammatory induction, which was compensated for by the AC treatment. Overall, AC positively affected the expression of the examined cell-binding structures forming the membrane on both cell types.
Analysis of Hybrid State Estimators: Accuracy and Convergence of Estimator Formulations

This paper provides a comprehensive analysis of several hybrid state estimators (HSEs) to assess their performance and identify their unique characteristics in transmission network. The results reveal that the formulation of an HSE can have a significant impact on both the estimation accuracy and the convergence properties of the estimator, which are the two most important performance factors for an HSE. Furthermore, the analysis performed has identified the formulation that maximizes these factors. The assessment can be divided into three parts. The first part conducts comprehensive simulations for the IEEE 14 bus test system for every possible phasor measurement units (PMU) placement. The second part validates the conclusions made in the first part using simulations of the IEEE 118 bus test system with both random PMU placements and optimally and suboptimally selected placements. The third part further validates these conclusions and directly explains the reasons for the differences in estimation accuracy observed for the different formulations of HSEs through mathematical analysis.
Managerial implications for global operations management

Purpose – Organisational transformation has been a major research theme over the last few decades. The main emphasis focuses on how successful organisations are using information systems and technology (IS/IT) to transform business operations. This paper aims to summarize and evaluate the key perspectives and concepts of change management. These perspectives and concepts are used to conduct an overview of the transformation of a major UK telecommunications company is using IS as a driver. Design/methodology/approach – This paper focuses on trying to understand the whole range of systems-related problems that may confront an organisation during the introduction of new operational systems as part of organisational change and transformation. The primary objective is to identify best practice. A case study focusing on a large organisation is the approach used to try and elicit learning. Findings – The view emerging from the case study is that there are generic problems that need to be addressed especially related to how system changes, processes and the customer are managed. Even with an increasing caseload of examples where large firms are unsuccessfully with major organisational transformations-companies are still willing to undergo this risky change process. Research limitations/implications – It is intended that this best practice framework will be used in other organisational environments. Originality/value – The paper contributes to widening studies on systems introduction as part of organisational change.
Electron‐cyclotron maser emission: Relative growth and damping rates for different modes and harmonics

We calculate and compare the temporal growth rate and the number of e-folding growths for the following wave modes due to a loss-cone-driven cyclotron maser: fundamental x, o, and z modes and second harmonic x and o modes. The dominant mode of the maser should be the fastest growing mode for a saturated maser and should be the mode with the greatest number of e-folding growths for an unsaturated maser; this mode is the fundamental x mode for ωp/Ωe ≲ 0.3, the z mode (or perhaps the fundamental o mode) for 0.3 ≲ ωp/Ωe ≲ 1.0, and the z mode (or perhaps the second harmonic x mode) for 1.0 ≲ ωp/Ωe ≲ 1.3. We discuss the effect of cyclotron damping by thermal electrons on the growth. Numerical calculations show that the effect is important only when the ratio of the mean energies of the thermal and maser emitting electrons exceeds 0.1–0.2. An analytic expression for the damping rate is derived and is used to show that some earlier treatments of cyclotron damping greatly overestimate the effect for loss-cone-driven maser emission. These results, when applied to AKR, imply that only either the fundamental x mode (for ωp/Ωe ≲ 0.3) or the z mode (for ωp/Ωe ≳ 0.3) is produced directly by maser emission. We suggest (1) that an o mode component in AKR might be due to partial reflection of x mode radiation incident onto sharp overdense plasma intrusions of the kind observed in the auroral cavity and (2) that a second harmonic component can be produced by coalescence of two z mode waves.
Impact of Customer Relationship Management (CRM) on Organizational Performance: A Study from the Perspective of Bangladesh

Customer relationship management is recognizing, attracting, obtaining, maintaining, and keeping profitable and faithful customers as the success of a business highly depends on them. The current study’s purpose is to measure the impact of customer relationship management on organizational performance. The study used Yamane’s (1967) formula to calculate the sample, and it has got 90 sample sizes and used semi-structured questionnaires containing pre-coded and open-ended questions. Descriptive statistics like frequency, percentages, and means have been performed. Besides, inferential statistics like correlation and regression analysis have been used to determine the relationship. The result showed that customer relationship management significantly and positively impacts organizational performance. The study will help the policy maker of any organization to rethink and give much more emphasis to customer relationship management.
Small check size pattern reversal visual evoked potentials (VEPs) in patients with chronic idiopathic intracranial hypertension

The condition known as idiopathic intracranial hypertension is characterized by elevated intracranial pressure. The most feared complication of IIH is visual loss due to papilledema and optic nerve atrophy. Visual evoked potentials are sensitive and non-invasive method. They are considered an important objective test in investigating suspected optic nerve disease. This study aims to clarify the effect of chronic increased ICP on the optic nerve. Methods: This case-control study was performed at Beni-Suef University Hospital on 60 female patients divided into two equal groups; Group (I): thirty female patients with chronic idiopathic hypertension and Group (II): thirty age and sex-matched healthy controls. All subjects were subjected to full neuro-ophthalmological assessment by PVEP, a lumbar puncture to measure CSF pressure, and radiological assessment using MRI. SPSS version 20 was used for the statistical analysis. Results: Right Pattern reversed VEP; for the check size 15min, the mean value of P100 latencies of chronic IIH was 109.88±10.46 and for controls was 97.35±4.23. The mean value of P100 amplitudes of chronic IIH was 11.73±5 and for controls was 11.95±3.3. Left pattern reversed VEP; for the check size 15min, the mean value of P100 latencies of chronic IIH was 111.42±11.5 and for controls was 97.13±4.32.
Magnetic field deflection in a 100 W Hall thruster with permanent magnets

The compact structure restrains the application of magnetic shielding in low-power Hall thrusters (LpHTs), leading to an asymmetric magnetic field or partial magnetic shielding of the channel wall. This study employs a trim coil to implement an asymmetric magnetic configuration in a 100 W laboratory Hall thruster. The locations of the maximum curvature of magnetic lines are deflected toward the inner and outer channel wall corresponding to the inward and outward deflected magnetic field configurations. Effects of the magnetic field deflection on the position of the ionization zone, efficiency of the thruster, discharge oscillations, and wall erosion are studied. Optical imaging and electrostatic probes are employed to monitor and scan the plasma beam. Experimental results show that the outward deflection induces a change in the magnetic mirror effect and alters the location of the ionization zone. The radial movement of the ionization zone away from the inner channel wall decreases the near-wall conductivity, reducing the electron current by 13.5% and promoting the current efficiency. Discharge oscillations are suppressed, and the propellant utilization efficiency is improved by 8.2%. Erosion of the channel wall shows an improvement of 40%. Generally, an outward deflected magnetic configuration can significantly improve the performance of LpHTs.
Total and inorganic arsenic in mid‐atlantic marine fish and shellfish and implications for fish advisories

Sampling was conducted in 2002 to determine the total concentration and chemical speciation of arsenic in several marine fish and shellfish species collected from the Delaware Inland Bays and the Delaware Estuary, both of which are important estuarine waterbodies in the US Mid‐Atlantic region that support recreational and commercial fishing. Edible meats from summer flounder (Paralicthys dentatus), striped bass (Marone saxatilis), Atlantic croaker (Micropogonias undulates), and hard clam (Mercenaria mercenaria) were tested. Total arsenic was highest in summer flounder, followed by hard clam, then striped bass, and finally, Atlantic croaker. Total arsenic was higher in summer flounder collected during the spring, as these fish migrated into the Inland Bays from the continental shelf, compared with levels in summer flounder collected during the fall, after these fish had spent the summer in the Inland Bays. Similarly, striped bass collected in the early spring close to the ocean had higher total arsenic levels compared with levels detected in striped bass collected later during the year in waters with lower salinity. Speciation of arsenic revealed low concentrations (0.00048–0.02 μg/g wet wt) of toxic inorganic arsenic. Dimethylarsinic acid was more than an order of magnitude greater in hard clam meats than in the other species tested, a finding that was attributed to arsenic uptake by phytoplankton and subsequent dietary uptake by the clam. Risk assessment using the inorganic arsenic concentrations was used to conclude that a fish consumption advisory is not warranted.
Benefits of Decision Support Systems in Relation to Task Difficulty in Airport Security X-Ray Screening

Abstract Automated explosive detection systems for cabin baggage screening (EDSCB) highlight areas in X-ray images of passenger bags that could contain explosive material. Several countries have implemented EDSCB so that passengers can leave personal electronic devices in their cabin baggage. This increases checkpoint efficiency, but also task difficulty for screeners. We used this case to investigate whether the benefits of decision support systems depend on task difficulty. 100 professional screeners conducted a simulated baggage screening task. They had to detect prohibited articles built into personal electronic devices that were screened either separately (low task difficulty) or inside baggage (high task difficulty). Results showed that EDSCB increased the detection of bombs built into personal electronic devices when screened separately. When electronics were left inside the baggage, operators ignored many EDSCB alarms, and many bombs were missed. Moreover, screeners missed most unalarmed explosives because they over-relied on the EDSCB’s judgment. We recommend that when EDSCB indicates that the bag might contain an explosive, baggage should always be examined further in a secondary search using explosive trace detection, manual opening of bags and other means.
Reliability Modelling through the Three-Parametric Weibull Model Based on Microsoft Excel Facilities

The paper aims to capitalize on the new features that are offered by the Microsoft Excel calculation program for reliability modeling, using the Median Ranks estimator that is calculated directly with the BETA.INV function, not estimated by various algebraic estimators, as is generally the case. Starting from this first step, a method of modeling reliability is elaborated through the three-parametric Weibull model that is based exclusively on this software, which is accessible to anyone and can be used even in the case of online learning, which is widespread in recent years due to the pandemic situation. The probability plotting method is applied, using the Median Ranks estimator that is calculated directly with the BETA.INV function for a probability equal to 0.5. A flowchart is made for the proposed method, which could be easily translated into a calculation program. By representing in logarithmic coordinates, we determined the Weibull models for different values that were initially adopted for the location parameter: using as a criterion the coefficient of determination that was obtained using the trendline function for the linear model, it was possible to identify, by successive tests, the optimal value of the location parameter—for which the three-parametric model has a good likelihood. By the proposed method, this value can be found following this iterative process. So, based on the current facilities of the Microsoft Excel program, a precise and easy-to-apply method has been achieved, through which an appropriate three-parametric Weibull model can be identified.
Highest economic status increases risk of cesarean section in women of childbearing age

BACKGROUNDCesarean section (CS) rates that are higher than the WHO recommendation may pose morbidity and mortality risks for both mother and child. In recent years, the number of CS deliveries has been increasing in developed and developing countries. The aim of the present study was to determine the rate of CS delivery and socioeconomic and demographic factors as risk factors of cesarean delivery in women of childbearing age. METHODSThis cross-sectional study used data from the 2017 Indonesian Health Demographic Survey (IDHS). The research subjects were 14,724 women of childbearing age aged 15-49 years who had given birth and met the inclusion criteria. The rate of CS was determined and the associations between independent and dependent variables were explored using logistic regression. RESULTSThe CS rate was 17.9%. Variables that had a significant relationship with cesarean delivery were geographic region, economic status, occupation, education, birth attendant, insurance ownership and antenatal care visits. The most dominant influencing variable was the highest economic status (OR 3.566; 95% CI: 2.857-4.452). Respondents with the highest economic status had a 3.5 times greater risk of having a cesarean delivery than subjects with the lowest economic status after controlling for the other variables. CONCLUSIONThis study demonstrated that the highest economic status increased the risk of CS delivery in women of childbearing age. The current epidemiological findings and evidence suggest adopting and implementing some strict guidelines in the health system to avoid unnecessary delivery by CS.
Simvastatin Loaded Dissolvable Microneedle Patches with Improved Pharmacokinetic Performance

Microneedle patches (MNPs) are one of the emerging approaches for drug delivery involving minimal invasion and improved skin penetration of macro- and micro-entities. Herein, we report dissolvable microneedle patches (dMNPs) as a novel tool for better systemic delivery of Simvastatin in the management of hypocholesteremia. Thiolated chitosan (TC), polyvinyl pyrolidone (PVP) and polyvinyl alcohol (PVA) were employed in the development of dMNPs. Developed patches were characterized through SEM, FTIR, DSC, TGA, PXRD, dissolution testing, tensile strength, elongation (%), skin irritation studies, moisture content and pharmacokinetic evaluation. dMNP F26 exhibited excellent tensile strength (9.85 MPa), penetration potential (~700 µm), moisture content (5.95%), elongation (35.54%) and Simvastatin release of 77.92%. Pharmacokinetic properties were also improved, i.e., Cmax 1.97 µg/mL, tmax 9 h, MRT 19.9 h and AUC 46.24 µg·h/mL as compared to Simvastatin solution displaying Cmax 2.55 µg/mL, tmax 3 h, MRT 5.91 h and AUC 14.20 µg·h/mL thus confirming higher and improved bioavailability. Kinetic modelling revealed zero order as the best fit model based on regression coefficient. Histopathological findings proved the biocompatibility of the developed dMNPs.
Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle

Recent studies have highlighted the importance of autophagy and particularly non-canonical autophagy in the development and progression of acute pancreatitis (a frequent disease with considerable morbidity and significant mortality). An important early event in the development of acute pancreatitis is the intrapancreatic activation of trypsinogen, (i.e., formation of trypsin) leading to the autodigestion of the organ. Another prominent phenomenon associated with the initiation of this disease is vacuolisation and specifically the formation of giant endocytic vacuoles in pancreatic acinar cells. These organelles develop in acinar cells exposed to several inducers of acute pancreatitis (including taurolithocholic acid and high concentrations of secretagogues cholecystokinin and acetylcholine). Notably, early trypsinogen activation occurs in the endocytic vacuoles. These trypsinogen-activating organelles undergo activation, long-distance trafficking, and non-canonical autophagy. In this review, we will discuss the role of autophagy in acute pancreatitis and particularly focus on the recently discovered LAP-like non-canonical autophagy (LNCA) of endocytic vacuoles.
Investigating the Repurchase Intention of E-Commerce Users from Service Quality and Expectation-Confirmation Theory Perspective

Most existing research concerning e-commerce in developed countries that have adopted information technology earlier than developing countries, such as Indonesia. The purpose of this study is to know the critical components of e-commerce service quality that can affect the level of customer satisfaction and loyalty in developing countries such as Indonesia using dimensions that researchers have tested in developed countries. The Smart Partial Least Square (SmartPLS 3.0) revealed a positive relationship among service quality, confirmation, satisfaction, and repurchase intention. A positive and significant correlation was also found between website design, information usefulness, privacy & security towards service quality. On the other hand, fulfillment and ease of ordering produced an insignificant relationship with service quality. Practical suggestions for promoting e-commerce in developing countries are provided.
Microstructured Flexible Pressure Sensor Based on Nanofibrous Films for Human Motions and Physiological Detection

Flexible pressure sensors have wide applications in artificial intelligence, wearable electronics, electronic skins, and health monitoring and have attracted extensive attention. However, it is still a serious challenge to obtain a flexible pressure sensor with high sensitivity, wide detection range, and excellent stability because of the contradiction between sensitivity and detection range. Here, we designed a flexible pressure sensor with a multilayer composite microstructure containing a nanofiber network and sea ZnO microparticles. The results indicate that our sensor has excellent sensitivity (147.02% kPa−1 for less than 0.5 kPa and 4.67% kPa−1 for 0.5-5 kPa), wide measuring range (0-5 kPa), fast response/relaxation times (50 ms/40 ms), and excellent repeatability. Furthermore, the pressure sensor can be applied to the detection and analysis of human motion and small physiological signals, including finger bending, elbow bending, and wrist pulse. Therefore, this pressure sensor has broad application prospects in wearable electronics, human–computer interaction, motion detection, and health monitoring.
Improved Poverty Tracking and Targeting in Jordan Using Feature Selection and Machine Learning

This paper improves on a recently proposed machine learning approach to assess and monitor the poverty status of Jordanian households. Without a doubt, accurate identification, tracking, and targeting households in poverty is a key to poverty alleviation. This work presents a nontraditional approach to the accurate prediction of poverty for Jordanian households using feature selection and machine learning. This approach can be seen as a support in the decision making process in the government and non-governmental organizations in an ever-shifting socio-economic environment. Using the Jordanian household expenditure and income surveys collected by the Department of Statistics (DoS), LightGBM predictive performance is improved to reach 83% F1-Score using only 41 features in contrast to 81% F1-score and 96 features in our previous work. At the heart of this work is determining which variables of household expenditure and income surveys are most predictive and how they can be most effectively combined. National surveys can now be run with fewer, more targeted questions that can greatly help in assessing the effectiveness of new policies and intervention programs rapidly and cheaply.