Miracle-dz/UniFAR-FTUs huggingface dataset:
Giant Cell Tumour Around Knee Managed by Curettage and Zoledronic Acid with Structural Support by Fibula Cortical Struts

Introduction: Giant cell tumour (GCT) of the bone is a benign tumour with a high tendency to recur after surgery. This study aimed to analyse prospectively the rate of local recurrence following management of giant cell tumours by curettage, using intravenous zoledronic acid as an adjuvant, and fibular struts to support the empty cavity after curettage. Materials and Methods: This study was carried out in ten cases of biopsy-proven GCTs: five males and five females, in the age group between 18 and 39 years. All patients were given three doses of zoledronic acid, one pre-operative and two post-operative. Extended curettage was done three weeks after the pre-operative dose of zoledronate. The cavity was left empty in all the cases. Fibular struts were used to support the cavity from collapse. Patients were followed-up for post-operative local recurrence. The functional status of the patients was assessed during each visit using the Musculoskeletal Tumour Society (MSTS) score. Results: There were no recurrences at a follow-up of two years. All patients had a stable knee and were able to bear weight fully. The average knee flexion was 75º. The average MSTS score of the study was 92%. Conclusion: Extended curettage using hydrogen peroxide, systemic zoledronic acid adjuvant and leaving the cavity empty without using cancellous bone graft did not lead to a recurrence of GCT. Non-vascularised fibular strut provided adequate support while the cavity left empty after curettage did not collapse and there was good knee function.
Extraction Behavior of Am(III) from Eu(III) with Hydrophobic Derivatives of N,N,N',N'-tetrakis(2-methylpyridyl)ethylenediamine (TPEN)

Reduction of radioactive toxicity of HLW is very important to decrease the risk of the environmental impact of nuclear wastes disposed to deep underground. The technique for the improvement of hydrophobicity of TPEN, which is one of properties that should be solved to construct MA/lanthanides separation process, is elucidated
Redox Dynamics of Arsenic Species in the Root‐Near Environment of Juncus effusus Investigated in a Macro‐Gradient‐Free Rooted Gravel Bed Reactor

In the framework of investigating the dynamics of As species within the planted soil beds of treatment wetlands, the redox dynamics of As species particularly in the root‐near environment of the rhizosphere were investigated. For this purpose, long‐term experiments were carried out using a specially designed macro‐gradient‐free rooted gravel bed reactor, planted with Juncus effusus to treat an artificial wastewater containing As (200 μg As/L). The exceptional quality of the biofilm processes at the helophyte root‐surfaces in treatment wetlands were of special importance in this investigation. The results showed that under C‐deficient conditions, a highly efficient As immobilization (> 85 %), obviously due to adsorption and/or co‐precipitation, was attained. The addition of organic carbon immediately caused an elevated As concentration and enrichment of As(III) (nearly 80 % of total As) in the reactor. Increasing the SO42– concentration in the artificial wastewater inflow facilitated a high As immobilization (> 82 %) under sulfate reducing condition. In principle, a highly efficient microbial dissimilatory sulfate reduction contributed to S2– formation and a greater As immobilization (most likely as As2S3) under C surplus and reducing conditions. Significant differences in As immobilization were observed by varying the inflow of the SO42– concentration (0.2, 5, 10, 25 S/L) under C surplus conditions. More As(III) precipitates (15 % less in the outflow) when the inflow of the SO42– concentration was decreased from 25 mg S/L to 10 mg S/L. Immobilized As showed greater instability by releasing As(V) (up to 85 % of total As) due to changes in the dynamic redox conditions inside the reactor. Re‐oxidation of reduced sulfur into other S species (e.g. S0, SO42–) due to plant‐root mediated O2 release probably caused an oxidative dissolution of already precipitated insoluble As (e.g. As2S3) and as a consequent As remobilization. The findings of this study highlighted the significance of SO42– in relation to organic C supply in planted soil beds treating As‐contaminated wastewater under constructed wetland conditions.
Hand and Wrist Injuries Among Collegiate Athletes: The Role of Sex and Competition on Injury Rates and Severity

Background: There is a high incidence of hand and wrist injuries in athletes participating in collegiate sports, but there is little information published characterizing them. Purpose: To characterize hand and wrist injuries in collegiate athletes using a large national database. Study Design: Descriptive epidemiology study. Methods: This retrospective cross-sectional analysis was designed using data from the National Collegiate Athletic Association (NCAA) Injury Surveillance Program database to identify hand and wrist injuries (exclusive of any radial or ulnar fractures) in male and female collegiate athletes participating in NCAA Division I, II, and III sports from 2004 to 2015. Descriptive analyses were performed on stratified data to examine the associations between these injuries and sport, event type, and sex. Results: Men’s ice hockey (8.25 per 10,000 athlete-exposures [AEs]) and women's ice hockey (8.21 per 10,000 AEs) had the highest rate of hand and wrist injuries in all exposures. In every sport except women’s gymnastics (P = .107), injuries were more commonly sustained during competition rather than during practice. Ligamentous injury to the phalynx was the most commonly sustained injury overall (1.416 per 10,000 AEs), and a metacarpal fracture was the most commonly sustained hand or wrist fracture (0.507 per 10,000 AEs). Injuries sustained during men’s wrestling (14.08 days) and women’s gymnastics (10.39 days) incurred the most time lost from sport. Surgery for hand and wrist injuries was most commonly required for men’s football (0.413 per 10,000 AEs) and women’s field hockey (0.404 per 10,000 AEs). Conclusion: Hand and wrist injuries were common among collegiate athletes. Male athletes experienced injuries with more frequency and severity. Injuries occurred more commonly during competition. While the majority of injuries were minor and did not require surgery, certain sports conferred a much higher risk of significant injuries requiring a surgical intervention.
Impacts of Social Distancing During the COVID-19 Outbreaks in Korea: Level 1 Trauma Center Data of Domestic Incidents and Intentional Injury

Objectives As a protective measure to slow down the transmission of coronavirus disease 2019 in Korea, social distancing was implemented from February 29th, 2020. This study aimed to evaluate the prevalence of domestic incidents and intentional injury during March 2020 when social distancing was in effect. Methods There were 12,638 patients who visited the Level 1 trauma center of Chungnam province with injuries from domestic incidents, familial discord, and intentional injury. The prevalence of injuries during March 2020 was compared with the average of the previous 5 years, and the average for every March between 2015 and 2019. Results The prevalence of domestic incidents in March 2020 was significantly higher than the 5-year average, and the average for every March from 2015 to 2019 (p < 0.001). Familial discord (p = 0.002) and intentional injury (p = 0.031) were more frequently observed in March 2020. Adolescents showed a markedly higher level of intentional injury in March 2020 than in both the 5-year average (p = 0.031), and average for every March over the previous 5 years (p = 0.037). Conclusion The prevalence of domestic incidents and intentional injury were significantly higher during the period of social distancing in Korea. There is a need for social consensus, better policies, and psychological support services, especially if faced with a second or third wave of coronavirus disease.
Signature changes in the expressions of protein-coding genes, lncRNAs, and repeat elements in early and late cellular senescence

Replicative cellular senescence is the main cause of aging. It is important to note that early senescence is linked to tissue regeneration, whereas late senescence is known to trigger a chronically inflammatory phenotype. Despite the presence of various genome-wide studies, there is a lack of information on distinguishing early and late senescent phenotypes at the transcriptome level. Particularly, the changes in the noncoding RNA portion of the aging cell have not been fully elucidated. By utilising RNA sequencing data of fibroblasts, hereby, we are not only reporting changes in gene expression profiles and relevant biological processes in the early and late senescent phenotypes but also presenting significant differences in the expressions of many unravelled long noncoding RNAs (lncRNAs) and transcripts arisen from repetitive DNA. Our results indicate that, in addition to previously reported L1 elements, various LTR and DNA transposons, as well as members of the classical satellites including HSAT5 and α-satellites (ALR/Alpha), are expressed at higher levels in late senescence. Moreover, we revealed finer links between the expression levels of repeats with the genes located near them and known to be involved in cell cycle and senescence. Noncoding elements reported here provide a new perspective to be explored in further experimental studies.
Solitary and Social Drinking in South Korea: An Exploratory Study

Objectives This study aimed to identify differences in drinking norms, heavy drinking, and motives between types of drinkers (abstainers, solitary, and social drinkers) in a representative sample of Korean adults. Methods An online survey of people registered on the electoral roll were randomly invited to be part of the “National Korean Drinking Culture Study” conducted in 2018 (n = 3,015). Participants included 1,532 men and 1,469 women aged 19–60 years. Questions included the number of times they drank in the last month, what they drank, and the volume drank. The amount of pure alcohol consumed was calculated. Drinking norms, motives, and types were determined in the survey questions. Results Solitary drinkers were more likely to be divorced or separated, less educated, and marginally employed. Solitary drinking peaked in those in their 30s (18.5%) and social drinkers in their 50s (68.1%). Solitary drinkers drank more frequently compared with social drinkers (6.1 vs. 3.6 times per month, p < 0.001), and consumed a significantly larger quantity of alcohol (69.5 g vs. 46.8 g per week). Solitary drinkers were more accepting of drinking-related behaviors in diverse situations compared with social drinkers. The regression analysis revealed that personal drinking motives were the most important factor influencing the frequency and quantity of alcohol consumption in both solitary and social drinking. Conclusion Solitary drinkers may be more vulnerable to alcohol abuse than social drinkers.
The inhibitory effect of melatonin on osteoclastogenesis of RAW 264.7 cells in low concentrations of RANKL and MCSF

RAW 264.7 cells are one of the most recommended cell lines for investigating the activity and differentiation of osteoclasts. These cells differentiate into osteoclasts in the presence of two critical components: receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage colony stimulating factor (MCSF). Melatonin (MEL) hormone has recently become one of the small molecules used in the field of bone regeneration and bone disease treatment, as it has the ability to inhibit the differentiation of osteoclasts directly by suppression of the NF-κB signaling pathway. The main aim of the current study is to determine sufficient RANKL/MCSF concentrations for differentiation of the cells to osteoclasts and to describe the repressive effect of MEL on the osteoclastogenesis of these cells. In this regard, it was found that 10 ng/mL of RANKL- and MCSF-containing medium is suitable for inducing osteoclastogenesis of the cells. In addition, melatonin at doses in the range of 100–1000 µM does not have a cytotoxic effect. Subsequently, results of tartrate resistant acid phosphatase (TRAP) activity, TRAP staining, and relative expressions of cathepsin K, nuclear factor of activated T cells one (NFATC1), and TRAP genes showed a suppressive effect of MEL —especially 800 µM— on RANKL-induced osteoclastogenesis of these cells.
Referral Time of Advance Cancer Patients to Palliative Care Services and Its Predictors in Specialized Cancer Center

Background and aim Globally, there is a discrepancy in whether terminal cancer patients are early referred to palliative care service (PCS) or not. A late referral can lead to a delay in treating and palliating those patients in need. The aim of this study is to investigate the referral time patterns of advanced cancer patients to PCS in Princess Noorah Oncology Center (PNOC) at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia. In addition, this study evaluates the factors that influence referral time to the palliative care unit (PCU), along with the overall survival rate. Methods This was a retrospective cross-sectional study (chart review) conducted at the inpatient unit in PNOC and included all patients referred to PCS between January 1st, 2016, and December 31, 2016. In total, 153 patients met the inclusion criteria, and their data were collected and analyzed. Results The median length of stay (LOS) was five days (95% CI: 3.85-6.15). Among the 153 patients, 22 (14.4%) died within 24 hours of enrollment to PCU. Patients who were referred to the PCU with non-metastasis disease had a median LOS of nine days, which is significantly longer than the median LOS in patients with metastatic disease (95% CI: 0.35-0.82, p=0.004), which indicates that they referred relatively earlier to PCU. The hazard ratio for death in patients with non-metastatic cancer stage was 0.54 (95% CI: 0.35-0.82, p=0.004). Conclusion Referral of advanced cancer patients to palliative care services occurs late in their disease course in our institution, like other institutions, with variation in LOS, which shorten their stay at palliative, as well as, affects their quality of life (QOL) and ability to plan or make a decision regarding their care. Education of the public and, most importantly, the medical community is needed.
Does previous biopsy lead to cancer overdiagnosis of superficial non-ampullary duodenal epithelial tumors?

Abstract Background and study aims We aimed to evaluate the diagnostic performance of magnifying endoscopy with narrow-band imaging (M-NBI) in superficial non-ampullary duodenal epithelial tumors (SNADETs) regarding the absence or presence of biopsy before M-NBI diagnosis. Patients and methods Clinicopathological data were retrospectively reviewed for 99 SNADETs from 99 patients who underwent endoscopic resection. The 99 tumors were divided into the non-biopsy group (32 lesions not undergoing biopsy before M-NBI examination) and the biopsy group (67 lesions undergoing biopsy before M-NBI examination). We investigated the correlation between the M-NBI diagnosis and the histopathological diagnosis of the SNADETs in both groups. Results According to the modified revised Vienna classification, 31 tumors were classified as category 3 (C3) (low-grade adenoma) and 68 as category 4/5 (C4/5) (high-grade adenoma/cancer). The accuracy, sensitivity, and specificity of preoperative M-NBI diagnoses in the non-biopsy group vs the biopsy group were 88 % (95 % confidence interval: 71.0 – 96.5) vs 66 % (51.5 – 75.5), P = 0.02; 95 % (77.2 – 99.9) vs 89 % (76.4 – 96.4), P = 0.39; and 70 % (34.8 – 93.3) vs 14 % (3.0 – 36.3), P < 0.01, respectively. Notably, in the biopsy group, the specificity of M-NBI in SNADETs was low at only 14 % because we over-diagnosed most C3 lesions as C4/5. M-NBI findings might have been compromised by the previous biopsy procedure itself. Conclusions In the non-biopsy group, the accuracy of M-NBI in SNADETs was excellent in distinguishing C4/5 lesions from C3. The M-NBI findings in SNADETs should be evaluated while carefully considering the influence of a previous biopsy.
Enantiomeric distribution of α-pinene, β-pinene and limonene in essential oils and extracts. Part 2. Oils, perfumes and cosmetics.

The enantiomers of α-pinene, β-pinene and limonene were directly determined in complex matrices by multidimensional gas chromatography using a non-chiral-chiral column combination. Essential oils, used for the preparation of perfumes and cosmetics, and commercially available perfumery products were analysed without sample clean-up. The enantiomeric distribution of the monoterpenes investigated allows a quality control of perfumes, a validation of essential oils as well as a differentiation of their natural or artificial origin.
EFEITO RESIDUAL DO LODO DE ESGOTO NAPRODUTIVIDADE DO MILHO SAFRINHA

Among the possibilities of final disposal of sewage sludge, agricultural recycling has become one of the most widely used in several developed countries, and is considered the most appropriate in technical, economical and environmental terms. This study aimed at evaluating the sewage sludge residual effect on off-season corn yield on an Eutroferric Red Latossol (Oxisol). The field experiment was in a randomized block design with three replications, with treatments consisting of increasing doses of sewage sludge (0, 6, 12, 24 and 36 t ha-1, on a dry weight basis), applied in the two previous cropping seasons. The residual effect of the application of lime-stabilized sewage sludge increased the yield of off-season corn; the grain yield under a rate of 36 t ha-1 was statistically higher than those under 6 and 12 t ha-1.
The Chemical Constituents from the Callus Culture of Trewia nudiflora

Five ent-atisane diterpenoids, including three new ones, i.e., (16 alpha)-17-hydroxy-ent-atisan-19-oic acid methyl ester (1), (16 alpha)-17-dihydroxy-ent-atisan-19-oic acid methyl ester (2), (16a)-ent-atisan-16,17,19-triol (3), and two known compounds, i.e., 17-hydroxy-ent-atisan-19-oic acid (4), (16 alpha)-16,17-dihydroxy-ent-atisan-19-al (5), together with one known diterpene glycoside, i.e., sumogaside, two known triterpenes, i.e., germanicone and (3 beta)-beta-amyrin, three known phenolic compounds, i.e., (+)-gallocatechin, (+)-catechin, and gallic acid, and two known sterols, i.e., beta-sitosterol and daucosterol, were isolated from the callus cultures of Trewia nudiflora. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR experiments. No maytansinoids were isolated or detected by LC-ESI-MS in the extracts of the calli, which suggests that the callus cultures can not produce maytansinoids under these conditions.
Dynamics of Spontaneous Spreading under Electrowetting Conditions

The dynamics of spontaneous spreading of drops is well described by the molecular kinetic theory. We show that it is also the case under electrowetting conditions for drops of glycerol on PTFE substrate. The associated friction between the liquid and the solid surface is independent of the applied voltage between 0 and 700 V.
Properties of the guest molecules in the 1,10-dibromodecane/urea inclusion compound. A molecular dynamics simulation study

A molecular dynamics (MD) simulation of the 1,10-dibromodecane/urea inclusion compound has been carried out at a temperature of 300 K to investigate various local structural properties of the 1,10-dibromodecane guest molecules within the urea tunnel structure. The bromine radial distribution function determined from the MD simulation indicates a broad distribution for the intermolecular BrA ⋯ Br distance, but considerably narrower distributions for intramolecular Br ⋯ C distances. This supports information determined experimentally viabromine K-edge EXAFS spectroscopy. The MD simulation provides evidence that a small proportion of the 1,10-dibromodecane molecules contain a gaucheend-group, and provides direct evidence for the interconversion between gaucheand trans end-group conformations on a timescale of the order of picoseconds. The MD simulation indicates that there is substantial dynamic disorder of the 1,10-dibromodecane guest molecules within the urea tunnel structure. These local structural properties and dynamic properties of the 1,10-dibromodecane guest molecules, determined from the MD simulation, are compared directly with corresponding information established viaexperimental approaches.
Methylene Blue and Hydrogen Peroxide for Photodynamic Inactivation in Root Canal - A New Protocol for Use in Endodontics

Objective: Antimicrobial photodynamic therapy (aPDT) is a controversial approach for endodontic disinfection. The objective of this study was to test the photosensitiser (PS) concentration and assess the optical shielding phenomenon, the use of hydrogen peroxide (H2O2) and minimal energy irradiation to optimise endodontic aPDT for suggesting a protocol for clinical use. Methods: Different parameters for aPDT were tested. Aqueous solutions of methylene blue (MB) at 50, 100, 150 and 300 μM were tested in vitro for optical shield and reactive oxygen species (ROS) production by the reduction of N,N-dimethyl-4-notrosoaniline (RNO) at 440 nm absorbance when irradiated using a diode laser (660 nm). Ten single-rooted teeth were inoculated with bioluminescent bacteria Pseudomonas aeruginosa for 72 hours to form biofilms. Bioluminescence imaging was used to serially evaluate the minimum energy necessary during endodontic aPDT using MB and a diode laser coupled to an optical fibre for intracanal microbial reduction. In addition, teeth (n=21) infected with Enterococcus faecalis were treated with sequential combinations of endodontic aPDT and H2O2 and the colony-forming unit (CFU) was determined. Results: ROS production was inversely proportional to the MB concentration in the solution due to quenching of MB. Optical shielding limited light penetration at high MB concentrations. The use of H2O2 before aPDT achieved higher disinfection compared to conventional aPDT or when MB was irradiated in an H2O2 solution. Energy irradiation of 9.6 J achieved a significant reduction and further light delivery did not produce further reduction. Conclusion: PS concentration of about 50 μM, biofilm pre-treatment with H2O2 for 1 min and energy irradiation around 10 J appear to be an effective protocol for endodontic aPDT.