Miracle-dz/UniFAR-FTUs huggingface dataset:
The ecology of human behavior: A network perspective

There is a broad agreement that some of the most relevant problems in the social and behavioral sciences are fundamentally structural, and as a consequence require structural explanations. Yet researchers disagree on what a structural explanation is, and what are the specific questions that can only be answered through a structural lens. In this study, I shed some light on the nature of structural explanations by distinguishing between three types of structural questions related to structural proximity, structural cohesion and structural importance. In addition, I show how graphical methods can be used to answer these questions. In particular, I argue that structure learning algorithms can help us gain some understanding regarding causal structures, and network science can help us understand the organization of these structures. I provide an empirical application of these methods using a nationally representative dataset with a wide range of factors related to child development.
Frequent Onsets of Cellulitis in Lower Limbs with Lymphedema Following COVID-19 mRNA Vaccination

Four patients with secondary lower limb lymphedema developed cellulitis at their lymphedema lesion following COVID-19 mRNA vaccinations. They did not develop adverse effects at their vaccination site. All the patients were Japanese females aged <60 years. Three patients developed cellulitis following the first vaccination. The date of onset of cellulitis following the first vaccination varied from 0 to 21 days. Two received BNT162b2 mRNA vaccines and the others received mRNA-1273 vaccines. All the patients were treated with oral antibiotics and recovered. Two patients had repeated cellulitis. The patients with the repeated development of cellulitis could not perform good skincare. One patient had joint contractures in their lower limbs and could not reach her lymphedema lesions, and the other patient could not master the skincare. According to previous studies, the development of cellulitis following vaccination was rare. In this study, four patients aged <60 years developed cellulitis among the eight patients that regularly visited our hospital for rehabilitation for their lower limb lymphedema. In patients with lymphedema, prolonged inflammation may impair lymphatic functions and worsen edema. Therefore, at the time of vaccination, we should keep in mind the prevention and immediate management of cellulitis using intensive skincare and antibiotic treatment.
Design of a System for Verification of Automatic Guided Vehicle Routes Using Computer Emulation

A frequent change in the manufacturing program caused by a change in customer requirements requires a logistics system in the company that can respond flexibly to these changes. In order for business logistics to respond flexibly and optimally to the tasks created, a tool is needed to verify the functionality of the entire process. This article, at its core, deals with the use of emulation in a mixed environment of the real and virtual worlds as a tool for optimising automatic guided vehicle (AGV) routes. The main objective of the article is the design of a system that allows verification of AGV routes using computer emulation. The solution was created and programmed in the Tecnomatix Plant Simulation program, in cooperation with AGV logistics supply tractors, and tested on a logistic test circuit. The results show that the main area of application of such a solution is mainly in the area of the capacity utilisation of the AGVs that are used in internal logistics processes. This solution helps to cut down on the time it takes to design and optimise logistics operations as well as on the time it takes to test logistics systems at full capacity before commencing production.
Morpho-structural and histochemical features of Plantago fengdouensis (Plantaginaceae) that reflect adaptations to an amphibious environment

ABSTRACT The perennial Plantago fengdouensis (Plantaginaceae) is an endangered amphibious plant native to the Three Gorge Reservoir Area, along the Yangtze River, China. Using brightfield and epifluorescence microscopy, we investigated the anatomical and histochemical features that allow this species to tolerate both submerged and terrestrial environments. The adventitious roots and rosette-like stems of P. fengdouensis had an endodermis inside the cortex, a uniseriate exodermis with Casparian bands and suberin lamellae, and phellem in the secondary structure; the cortex persisted to the root base. Dilated cells were found in the endodermis and inner cortex of the roots. The endodermis and sclerenchyma layer are present as a continuum from the roots to leaves, shoots are covered by cuticle, also. Air spaces were present in the roots and shoots. These anatomical and histochemical features may reflect adaptations that permit P. fengdouensis to thrive in the riparian zone of the Three Gorges, China.
Predictive Markers for Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer

Immune checkpoint inhibitors (ICIs) have dramatically improved the outcomes of non-small cell lung cancer patients and have increased the possibility of long-term survival. However, few patients benefit from ICIs, and no predictive biomarkers other than tumor programmed cell death ligand 1 (PD-L1) expression have been established. Hence, the identification of biomarkers is an urgent issue. This review outlines the current understanding of predictive markers for the efficacy of ICIs, including PD-L1, tumor mutation burden, DNA mismatch repair deficiency, microsatellite instability, CD8+ tumor-infiltrating lymphocytes, human leukocyte antigen class I, tumor/specific genotype, and blood biomarkers such as peripheral T-cell phenotype, neutrophil-to-lymphocyte ratio, interferon-gamma, and interleukin-8. A tremendous number of biomarkers are in development, but individual biomarkers are insufficient. Tissue biomarkers have issues in reproducibility and accuracy because of intratumoral heterogeneity and biopsy invasiveness. Furthermore, blood biomarkers have difficulty in reflecting the tumor microenvironment and therefore tend to be less predictive for the efficacy of ICIs than tissue samples. In addition to individual biomarkers, the development of composite markers, including novel technologies such as machine learning and high-throughput analysis, may make it easier to comprehensively analyze multiple biomarkers.
Wire bond temperature sensor

This work reports the first demonstration of a bond pad test structure with embedded thermopile sensors for the measurement of the transient temperature response during the wire bonding operation. This paper will present the design and operation of the bond pad test structure and show and discuss temperature measurements during the wire bonding operation. The test structure can be used directly on the bond pads without any modification to the bonding machine or imposition of constraints on the wire material. The thermocouple junctions are created by the aluminum-polysilicon contacts that are available in the standard CMOS process. This configuration does not require an external bias for the detector, as has been utilized in other studies. The test structure can be used in industrial applications for testing and calibrating wire bonding tools. Researchers can also use it as a probe for validating physics-based models of the wire bonding process. The device has been used for measuring the temperature response during ball bonding using 25 μm diameter gold wire. Measurements are reported for selected force and ultrasonic power settings and show generally expected trends. The sensor captures the cooling of the bond-pad by the gold ball and the heating due to the ultrasonic energy application. The results of this study are in qualitative agreement with a previous study using resistive temperature sensors.
The effect of using acidified turmeric on some productive parameters and intestinal bacterial counts in broilers at high stocking density pens

Objective: This work investigated the impact of acidified turmeric on growth, blood profile, and gut bacterial counts of broiler chickens stocked in an overcrowding stress condition. Materials and Methods: A total of 285 14-day-old Lohmann broiler strains were distributed to T0 (chicks receiving basal feed raised at a density of 9 chicks/m2), T1 (chicks receiving basal feed raised at 16 chicks/m2), T2 (chicks receiving 1% turmeric powder raised at 16 chicks/m2), and T3 (chicks receiving 1% acidified turmeric powder raised at 16 chicks/m2). Body weight and feed intake were determined weekly. On day 37, blood and intestinal content were collected and analyzed. Results: Body weight was higher while feed conversion ratio was lower in T0 than in other groups. Compared to T0, T1 had a lower thymus weight. Erythrocytes and hematocrits were greater in T0 than in T2 and T3. Hemoglobin was higher in T0 than in T3. Serum superoxide dismutase differed as T0 < T1 < T2. Ileal coliform was higher in T0 than in T1 and T3. Lactic acid bacteria counts were higher in T0 and T1 than in T2 and T3. Conclusions: Acidified turmeric was capable of maintaining the relative weight of the immune organ and ameliorating the oxidative stress of the broiler during overcrowding stress.
Molecular Subtypes as a Basis for Stratified Use of Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer—A Narrative Review

Simple Summary Although it is one disease, cancer of the urinary bladder occurs in several molecular subtypes that can be identified by laboratory tests. Tumors of advanced stages are treated with surgical removal of the urinary bladder with or without addition of chemotherapy. About 50% of patients are cured by surgery and this proportion is increased slightly by the addition of chemotherapy. Still, many patients do not benefit from chemotherapy, which also comes with significant toxicity. Recent advances in the field suggest that molecular subtypes can help identify patient categories that do or do not benefit from adding chemotherapy to surgery. In this article, we review the literature and conclude that molecular subtypes are likely to have such a role in the future but that there are differences between studies that make them challenging to compare. The current evidence is insufficient to guide clinical practice. Abstract There are no established biomarkers to guide patient selection for neoadjuvant chemotherapy prior to radical cystectomy for muscle-invasive bladder cancer. Recent studies suggest that molecular subtype classification holds promise for predicting chemotherapy response and/or survival benefit in this setting. Here, we summarize and discuss the scientific literature examining transcriptomic or panel-based molecular subtyping applied to neoadjuvant chemotherapy-treated patient cohorts. We find that there is not sufficient evidence to conclude that the basal subtype of muscle-invasive bladder cancer responds well to chemotherapy, since only a minority of studies support this conclusion. More evidence indicates that luminal-like subtypes may have the most improved outcomes after neoadjuvant chemotherapy. There are also conflicting data concerning the association between biopsy stromal content and response. Subtypes indicative of high stromal infiltration responded well in some studies and poorly in others. Uncertainties when interpreting the current literature include a lack of reporting both response and survival outcomes and the inherent risk of bias in retrospective study designs. Taken together, available studies suggest a role for molecular subtyping in stratifying patients for receiving neoadjuvant chemotherapy. The precise classification system that best captures such a predictive effect, and the exact subtypes for which other treatment options are more beneficial remains to be established, preferably in prospective studies.
Collaborating on Web 2.0 Technologies: The Best-Fit Model for the Behavioral Intentions of Preservice Teachers

Professional collaborative partnerships among teachers are essential in delivering appropriate services, in an inclusive classroom for students with disabilities. Web 2.0 technologies are new, yet largely unexamined, tools that may be used to facilitate collaborative partnerships. Teacher preparation programs are currently attempting to understand the behavioral intention of preservice teachers on these new technologies. A total of 590 preservice teachers participated in this study and reported their current use, perceived benefits, and behavioral intentions on Web 2.0 technologies. The Decomposed Theory of Planned Behavior (DTPB) was used as a theoretical framework to help guide the study and identify possible behavior intention factors. The collected data was analyzed through Structural Equation Modeling (SEM) to find a best-fit path model that would lead to the behavioral intention of preservice teachers to use Web 2.0 technologies. This study found that preservice teachers are using Web 2.0 technologies at an increasing rate in their teacher preparation programs. Preservice teachers also reported perceiving peer interaction and sharing resources as the greatest collaborative benefits of these technologies. When the combined factors of attitude, subjective norms, and perceived behavioral control were identified, preservice teachers intend to collaborate on Web 2.0 technologies as professional teachers. Teacher preparation program faculty should be encouraged to use Web 2.0 technologies in their courses, with the understanding that it will benefit the future collaboration of teachers. COLLABORATING ON WEB 2.0 TECHNOLOGIES
The relationships between κ-casein (CSN3) gene polymorphism and some performance traits in Simmental cattle

Abstract In this study we aim to examine genotypic structures in terms of the κ -casein (CSN3) gene locus in 70 head of Simmental cattle raised in a private enterprise in Erzurum to determine the distribution of genotypes and allele frequencies in cattle in terms of related genes and to correlate the determined genotypes with some performance characteristics. CSN3/HinfI gene polymorphisms were identified in DNA isolated from blood samples taken from Simmental cattle used in the study using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. The frequency of the AA, AB, and BB genotype of the CSN3 gene in the population was 57.14 %, 32.86 %, and 10.00 %, respectively; the frequency of the A allele was 0.74; and the frequency of the B allele was 0.26. The mean value for the AA, AB, and BB genotypes was 5151 ± 308.6, 5805 ± 370.3, and 5772 ± 547.3 kg for real milk yield, respectively; 5313 ± 233.9, 5784 ± 280.7, and 6458 ± 414.8 kg in 305 d for milk yield; 17.9 ± 0.75, 18.6 ± 0.89, and 19.6 ± 1.32 kg for daily milk yield; and 294 ± 13.7, 316 ± 16.5, and 294 ± 24.4 d during the lactation period. The distribution of the CSN3 gene locus in the studied population is in genetic equilibrium according to the Hardy–Weinberg principle. The genotype and allele frequencies determined in terms of CSN3 gene polymorphism can be considered sufficient to reveal the genotype diversity of the breed, and it was determined that the relationship of CSN3 genotypes was only significant with 305 d milk yield ( P<0.05 ) in terms of the association between CSN3 genotypes and some performance traits. It has been concluded that animals with the CSN3 BB genotype have an economic advantage within the herd and that CSN3 can be used for marker-assisted selection (MAS) in this regard.
Botanical from the Fruits Mesocarp of Raphia vinifera Displays Antiproliferative Activity and Is Harmless as Evidenced by Toxicological Assessments

Raphia vinifera is widely used to treat several diseases including digestive disorders, dysentery, and genitourinary infections. In this study, the mineral contents, the cytotoxicity, and the toxicological effect of the crude CHCl3/MeOH extract (RVM) from the mesocarp of Raphia vinifera were evaluated. The mineral contents were evaluated using the method described by the Association of Official Analytical Chemists (AOAC). The cytotoxicity of both extract and chemical compounds from the plants was determined by a resazurin reduction assay (RRA). The toxicological studies were carried out using the experimental procedure of the Organization for Economic Cooperation and Development (OECD). After killing the rats, biochemical, histopathological, and hematological studies were performed. The result indicated that RVM is rich in zinc (6.52 mg/100 g of DM) and sodium (194.5 mg/100 g of DM). RVM had a cytotoxicity effect with IC50 values lower than 30 μg/mL in 18/18 cancer cell lines tested. These recorded IC50 values were between 12.35 µg/mL (toward CCRF-CEM leukemia cells) and 26.66 µg/mL (toward SKMel-505 BRAF wild-type melanoma cells). Raphvinin 4 displayed good cytotoxicity against MaMel-80aBRAF-V600E homozygous mutant with the IC50 of 10.42 μM. RVM was relatively nontoxic to rats, the median lethal dose (DL50) being above 5000 mg/kg body weight. However, during the oral administration period extending for 28 days, precautions should be taken due to the increase in urinary creatinine level and decrease in spleen weight in the male rats given the highest dose (1000 mg/kg) of extract. Conclusively, the extract of Raphia vinifera is weakly toxic in rats and could be further used in the development of anticancer phytomedicines.
PENGARUH MUTASI, LINGKUNGAN KERJA, DAN MOTIVASI KERJA TERHADAP KEPUASAN KERJA PEGAWAI PADA PT. CIPTA ANEKA SELERA INDONESIA

Sumber Daya Manusia merupakan salah satu faktor penting bagi perusahaan dalam rangka mencapai tujuan yang diharapkan. Terkait hal tersebut, strategi pengembangan SDM harus senantiasa dilakukan agar perusahaan dapat memiliki Sumber Daya Manusia yang berkualitas dan kompeten. Selain itu, perusahaan juga perlu memperhatikan hal lain terkait SDM yakni salah satunya adalah kepuasan kerja. Kepuasan kerja merupakan suatu tanda apakah suatu perusahaan telah dikelola dengan baik atau tidak. Selanjutnya, terdapat beberapa faktor yang mempengaruhi kepuasan kerja antara lain mutasi, motivasi kerja, dan lingkungan kerja. Sementara itu, PT. Cipta Aneka Selera merupakan salah satu perusahaan di bidang food frenchise yang memperhatikan kepuasan kerja para pegawainya. Dalam kegiatan operasionalnya, PT. CAS seringkali melakukan mutasi sebagai salah satu bentuk dari strategi pengembangan SDM. Selain itu, diberlakukan atau tidaknya mutasi, lingkungan kerja serta motivasi kerja yang berbeda di kalangan pegawai menjadi perhatian PT. CAS saat ini. Ketiga faktor ini kemudian disinyalir memberikan kontribusi terhadap kepuasan kerja pegawai PT. CAS yang dinilai mengalami penurunan. Tujuan penelitian ini adalah untuk mengetahui apakah mutasi, lingkungan kerja dan motivasi kerja berpengaruh terhadap kepuasan kerja pada pegawai PT. CAS Indonesia. Metode yang digunakan adalah kuantitatif dengan analisis regresi linier. Pengolahan data dilakukan dengan menggunakan software SPSS 24.
The Academic Supervision Before and During the Covid-19 Pandemic and The Factors That Influence Them

Masalah yang muncul saat ini adalah rendahnya kinerja pendidik, sehingga diperlukan pemimpin yang dapat meningkatkan kinerja pendidik. Tujuan penelitian ini adalah menganalisis pelaksanaan supervisi akademik sebelum dan selama masa pandemi serta untuk mengetahui kendala yang harus dilakukan sekolah dalam melakukan supervisi akademik oleh kepala sekolah. Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Data yang terkumpul ditulis dalam bentuk deskripsi. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah teknik purposive sampling. Subjek penelitian ini adalah empat kepala sekolah dan enam guru. Metode pengumpulan data dalam penelitian ini menggunakan teknik wawancara, observasi, dan studi dokumen. Instrumen yang digunakan dalam pengumpulan data yaitu kuesioner. Teknik analisis data yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Hasil penelitian ini yaitu pertama, pelaksanaan supervisi akademik sebelum pandemi keempat sekolah sudah baik dan mengikuti langkah-langkah supervisi akademik yang benar. Kedua, pelaksanaan supervisi akademik pada masa pandemi masih belum terlaksana dengan baik, hanya satu sekolah yang dapat melakukan supervisi akademik dengan baik. Ketiga, kendala yang terjadi adalah rasio kepala sekolah dan guru yang tidak seimbang, beban kerja kepala sekolah yang tinggi, kejadian mendadak yang membuat supervisi akademik dijadwal ulang, dan guru yang belum siap. Kendala di masa pandemi adalah sulitnya melakukan penilaian sesuai dengan standar instrumen supervisi akademik, kurang komunikasi antara kepala sekolah dan guru, dan sulitnya memantau prestasi belajar.
Early and mid-term results of Tönnis lateral acetabuloplasty for the treatment of developmental dysplasia of the hip

Objectives This study aimed to present the clinical and radiological results of a large patient group operated by Tönnis lateral acetabuloplasty (TLA) for developmental dysplasia of the hip (DDH). Patients and methods The retrospective study was conducted with 66 hips of 41 patients (5 males, 36 females; mean age: 32.3±18 months; range, 11 to 132 months) operated for DDH using the TLA technique in a single center between February 2012 and December 2016. Adductor tenotomy was performed on 52 (79%) hips. There was a need for additional femoral shortening and derotation-varization osteotomy in 14 (21%) hips. Clinical outcomes were evaluated with modified McKay criteria. The acetabular index and lateral migration index for the subluxated hip were calculated, and the femoral head position was evaluated according to Perkin’s line and Shenton’s line. The Severin classification was used to assess the outcome of the hips. Results The mean follow-up period was 27±11 months. According to the modified McKay criteria for DDH, 77.3% of hips were classified as excellent, 16.6% as good, and 6.1% as fair. The mean acetabular index decreased from 36.1° preoperatively to 18.6° postoperatively. The mean postoperative improvement for the acetabular index was 17.5±5. The lateral migration index improved from 89.7 to 10.6%. A statistically significant difference was determined between the preoperative and postoperative measurements of the acetabular index and lateral migration index (p<0.001). Conclusion Tönnis lateral acetabuloplasty was found to be safe and effective with a low learning curve, and successful treatment decreases the duration of follow-up required in patients with DDH.