Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of education on patients’ psycho-emotional status during allogeneic hematopoietic stem cell transplantation: a multicenter prospective study by thes Gruppo Italiano Trapianto di Midollo Osseo

Abstract Purpose Depressive disorders are the most common manifestation of psychological distress in allogenic hematopoietic stem cell transplantation. Few studies have yet investigated the relationship between therapeutic educational interventions and outcomes in these patients with specific attention to those related to mental health. Aim of this study was to understand how much educational intervention can represent a protective factor in preventing psycho-emotional distress-related issues in this setting. Design A prospective observational study of a multicenter cohort was conducted. Participants Adult patients undergoing allogeneic hematopoietic stem cell transplantation. Methods A pre-transplant therapeutic educational programme was offered to a cohort of adult patients undergoing allo-HSCT recruited in ten transplant centers of the GITMO network between May 2018 and January 2019. Depression, Anxiety and Stress scale was used to collect data on psycho-emotional distress at admission (T0), at the day of transplant (T1) and at discharge (T2). Descriptive data were collected and reported, and comparative analyses were done among patients who were compliant with the pre-transplant educational intervention and those who did not (for any reason). Findings A cohort of 133 allo-HSCT patients was observed. In patients who did not receive pre-transplant educational intervention, higher levels of depression at admission (p = 0.01) and at the day of transplant (p = 0.03), higher levels of anxiety (p = 0.01 and p = 0.01 respectively) as well as higher levels of stress (p < 0.01 and p = 0.01) were observed. Problem solving and “face to face” interview were the best methods to provide education to patients. Those who received pre-transplant education through “face-to-face” interview reported significant low levels of depression during the whole hospital stay period (p < 0.01; p = 0.01; p = 0.01) and less anxiety and stress at admission (p < 0.05 and p = 0.01 respectively). Depression was more represented in female than male participants at T0 (16.5% vs 9.0%; p = 0.01), while among T0 and T2 the males had a significant higher increasing of depression than females (p = 0.03). Conclusion Our study demonstrated that pretreatment therapeutic educational programs with specific learning modalities can be effective in limiting the potential risk of developing moderate-to-severe anxiety-depressive states and stress symptoms related to allo-HSCT. Implications for psychosocial providers Further studies are needed to confirm our results and to understand whether containing psycho-emotional distress can have any relationship with medium- and long-term post-transplant complications.
Sex differences in the association between systemic oxidative stress status and optic nerve head blood flow in normal-tension glaucoma

Purpose To investigate the association of systemic oxidative stress markers and optic nerve head (ONH) blood flow in normal-tension glaucoma (NTG) patients, as well as sex differences in this association. Methods This was a cross-sectional study of 235 eyes with NTG of 134 patients (56 male, 78 female; mean age, 60.9±14.1 years). Laser speckle flowgraphy (LSFG) was used to measure ONH blood flow (mean blur rate in the tissue area of the ONH; MBR-T) and LSFG pulse-waveform parameters, including flow acceleration index in the tissue area of the ONH (FAI-T). Oxidative stress markers, diacron-reactive oxygen metabolites (d-ROMs), and biological antioxidant potential (BAP) were measured with a free radical elective evaluator. Spearman’s rank correlation test and a multivariate linear mixed-effect model were used to investigate factors associated with ONH blood flow. Results MBR-T was significantly correlated with age (rs = -0.28, p < 0.001), mean arterial pressure (rs = -0.20, p = 0.002), intraocular pressure (rs = 0.24, p < 0.001), peripapillary retinal nerve fiber layer thickness (rs = 0.62, p < 0.001), and disc area (rs = -0.26, p < 0.001), but not with serum d-ROM level. Separate analyses of the subjects divided by sex showed that BAP was positively correlated to MBR-T (rs = 0.21, p = 0.036) and FAI-T (rs = 0.36, p < 0.001) only in male subjects. Similarly, BAP was significantly associated with MBR-T (β = 0.25, p = 0.026) and FAI-T (β = 0.37, p < 0.001) in male subjects in a multivariate linear mixed-effect model. Conclusion A lower serum antioxidant level, as indicated by BAP, was associated with reduced ONH blood flow only in male NTG patients. Our findings suggest that there are sex differences in the involvement of oxidative stress in the pathogenesis of reduced ocular blood flow in NTG.
Global Prevalence and Mental Health Outcomes of Intimate Partner Violence Among Women: A Systematic Review and Meta-Analysis

The aim of this systematic review was to assess the magnitude of the association between types of intimate partner violence (IPV) and mental health outcomes and shed light on the large variation in IPV prevalence rates between low- to middle-income countries and high-income countries. The study is a systematic review and meta-analysis. The following databases were searched for this study: Cochrane, MEDLINE, EMBASE, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, and the Applied Social Sciences Index and Abstracts. The inclusion criteria for this study are as follows: quantitative studies published from 2012 to 2020 on IPV exposure in women aged 16+, using validated measures. Random effects meta-analyses and subgroup analysis exploring heterogeneity across population groups in different economic contexts are used in this study. In all, 201 studies were included with 250,599 women, primarily from high-income countries. Higher prevalence rates were reported for women’s lifetime IPV than past year IPV. Lifetime psychological violence was the most prevalent form of IPV. Women in the community reported the highest prevalence for physical, psychological, and sexual violence in the past year compared to clinical groups. Perinatal women were most likely to have experienced lifetime physical IPV. Prevalence rates differed significantly (p = .037 to <.001) for “any IPV” and all subtypes by income country level. Meta-analysis suggested increased odds for all mental health outcomes associated with IPV including depression (odds ratio [OR] = 2.04–3.14), posttraumatic stress disorder (PTSD) (OR = 2.15–2.66), and suicidality (OR = 2.17–5.52). Clinical and community populations were exposed to high prevalence of IPV and increased likelihood of depression, PTSD, and suicidality. Future research should seek to understand women’s perspectives on service/support responses to IPV to address their mental health needs. Work with IPV survivors should be carried out to develop bespoke services to reduce IPV in groups most at risk such as pregnant and/or help-seeking women.
Rapid improvement of systemic sclerosis-associated intestinal pseudo-obstruction with intravenous immunoglobulin administration

Abstract Objectives SSc is an autoimmune disease characterized by excessive fibrosis in multiple organs, including the gastrointestinal (GI) tract. GI symptoms of SSc such as intestinal pseudo-obstruction (IPO) are often refractory to conventional intervention and can result in longer in-hospital stay or even increased mortality. We aimed to summarize the insights to date regarding the efficacy of IVIG against GI symptoms of SSc to unveil what we should focus on in future studies. Methods Herein we report the response of GI symptoms in three cases with SSc-myositis overlap who received IVIG administration. We also conducted a systematic literature review to summarize previous reports regarding the efficacy of IVIG upon the GI manifestations of SSc, according to the PRISMA 2020 guideline. Results The case series demonstrated remarkable and rapid improvement of GI symptoms, including IPO, after IVIG administration. The literature review revealed that previous reports also support the efficacy and safety of IVIG against GI manifestations of SSc. However, they were all retrospective studies and lacking description of the short-term outcome after IVIG administration with objective and quantitative metrics. Conclusion IVIG seems to be a promising therapeutic option for the management of GI symptoms in SSc, including IPO. Investigators should focus more on short-term outcomes to properly assess the therapeutic benefit of IVIG, ideally using reliable quantitative measures in a multicentre randomized placebo-controlled setting.
Integral equation based modeling of the interaction between piezoelectric patch actuators and an elastic substrate

An integral equation based model for a system of piezoelectric flexible patch actuators bonded to an elastic substrate (layer or half-space) is developed. The rigorous solution to the patch–substrate dynamic contact problem extends the range of the model’s utility far beyond the bounds of conventional models that rely on simplified plate, beam or shell equations for the waveguide part. The proposed approach provides the possibility to reveal the effects of resonance energy radiation associated with higher modes that would be inaccessible using models accounting for the fundamental modes only. Algorithms that correctly account for the mutual wave interaction among the actuators via the host medium, for selective mode excitation in a layer as well as for body waves directed to required zones in a half-space, have also been derived and implemented in computer code.
Prevalence, Perpetrators, and Factors Associated With Intimate Partner Violence Among Adolescents Living in Urban Slums of Kampala, Uganda

Intimate partner violence (IPV) poses a public health burden, yet few studies have assessed co-existence of physical, emotional, and sexual IPV among adolescents. We assessed recent IPV victimization and associated factors and described IPV patterns and perpetrators among young people from urban slums in Kampala, Uganda. We conducted a prospective cohort study among 14 to 19-year-old individuals enrolled from March 2019 to March 2020 and followed quarterly for 12 months. We collected data on socio-demographics, sexual behavior, and substance use through interviews. Recent IPV victimization was documented at all visits if a participant reported experiencing physical, emotional, and/or sexual IPV in the past 3 months. Baseline factors associated with recent IPV victimization were determined using multivariable logistic regression. We enrolled 490 adolescents (60.6% female) with median age 18 years (Interquartile range (IQR) 17–18 years), 91.0% had less than secondary level education. Females mainly engaged in sex work (17.5%) and selling fruits/snacks (9.1%) while males commonly earned from sale of metal scrap or plastic waste (28.5%), 41% reported ≥10 life-time sexual partners, 16.1% were high-risk alcohol drinkers and 34.9% used illicit drugs in the past 3 months. Overall, 27.8% reported recent IPV victimization (20.0% females) with emotional IPV being common (17.8%). At baseline, recent IPV victimization was associated with high-risk alcohol consumption (adjusted odds ratio [aOR] 2.57; 95% confidence interval [CI] [1.44, 4.58]), reported paid sex in the past 3 months (aOR 1.82; [1.02, 3.22]) and being separated (aOR 2.47; [1.29, 4.73]). Recent IPV victimization declined from baseline to month 9 and increased at month 12 visits which coincided with the COVID-19 pandemic. IPV victimization is high among young people living in urban slums with emotional IPV being prevalent. IPV interventions are needed and should also address excessive alcohol consumption.
State estimation and data fusion for multirate sensor networks

This article is concerned with state estimation and data fusion of a linear dynamic system observed by multirate sensors in the environment of wireless sensor networks. The sampling, estimation, and transmission rates in the wireless sensor networks are different. We derive the optimal linear estimation in the centralized, sequential, and distributed forms. A numerical example is given to show the feasibility and effectiveness of the proposed algorithms. Copyright © 2015 John Wiley & Sons, Ltd.
Application of Malliavin Calculus and Wiener Chaos to Option Pricing Theory (1st Phd Manuscript)

This dissertation provides a contribution to the option pricing literature by means of some recent developments in probability theory, namely the Malliavin Calculus and the Wiener chaos theory. It concentrates on the issue of faster convergence of Monte Carlo and Quasi-Monte Carlo simulations for the Greeks, on the topic of the Asian option as well as on the approximation for convexity adjustment for fixed income derivatives. The first part presents a new method to speed up the convergence of Monte- Carlo and Quasi-Monte Carlo simulations of the Greeks by means of Malliavin weighted schemes. We extend the pioneering works of Fournie et al. (1999), (2000) by deriving necessary and sufficient conditions for a function to serve as a weight function and by providing the weight function with minimum variance. To do so, we introduce its generator defined as its Skorohod integrand. On a numerical example, we find evidence of spectacular efficiency of this method for corridor options, especially for the gamma calculation. The second part brings new insights on the Asian option. We first show how to price discrete Asian options consistent with different types of underlying densities, especially non-normal returns, by means of the Fast Fourier Transform algorithm. We then extends Malliavin weighted schemes to continuous time Asian options. In the last part, we first prove that the Black Scholes convexity adjustment (Brotherton-Ratcliffe and Iben (1993)) can be consistently derived in a martingale framework. As an application, we examine the convexity bias between CMS and forward swap rates. However, for more complicated term structures assumptions, this approach does not hold any more. We offer a solution to this, thanks to an approximation formula, in the case of multi-factor lognormal zero coupon models, using Wiener chaos theory.
Decay rates and cutoff for convergence and hitting times of Markov chains with countably infinite state space

For a positive recurrent continuous-time Markov chain on a countable state space, we compare the access time to equilibrium to the hitting time of a particular state. For monotone processes, the exponential rates are ranked. When the process starts far from equilibrium, a cutoff phenomenon occurs at the same instant, in the sense that both the access time to equilibrium and the hitting time of a fixed state are equivalent to the expectation of the latter. In the case of Markov chains on trees, that expectation can be computed explicitly. The results are illustrated on the M/M/∞ queue.
Racial differences in time to blood pressure control of aneurysmal subarachnoid hemorrhage patients: A single-institution study

Background and purpose Aneurysmal subarachnoid hemorrhage occurs in approximately 30,000 patients annually in the United States. Uncontrolled blood pressure is a major risk factor for aneurysmal subarachnoid hemorrhage. Clinical guidelines recommend maintaining blood pressure control until definitive aneurysm securement occurs. It is unknown whether racial differences exist regarding blood pressure control and outcomes (HLOS, discharge disposition) in aneurysmal subarachnoid hemorrhage. Here, we aim to assess whether racial differences exist in 1) presentation, 2) clinical course, and 3) outcomes, including time to blood pressure stabilization, for aSAH patients at a large tertiary care medical center. Methods We conducted a retrospective review of adult aneurysmal subarachnoid hemorrhage cases from 2013 to 2019 at a single large tertiary medical center. Data extracted from the medical record included sex, age, race, insurance status, aneurysm location, aneurysm treatment, initial systolic and diastolic blood pressure, Hunt Hess grade, modified Fisher score, time to blood pressure control (defined as time in minutes from first blood pressure measurement to the first of three consecutive systolic blood pressure measurements under 140mmHg), hospital length of stay, and final discharge disposition. Results 194 patients met inclusion criteria; 140 (72%) White and 54 (28%) Black. While White patients were more likely than Black patients to be privately insured (62.1% versus 33.3%, p < 0.001), Black patients were more likely than White patients to have Medicaid (55.6% versus 15.0%, p < 0.001). Compared to White patients, Black patients presented with a higher median systolic (165 mmHg versus 148 mmHg, p = 0.004) and diastolic (93 mmHg versus 84 mmHg, p = 0.02) blood pressure. Black patients had a longer median time to blood pressure control than White patients (200 minutes versus 90 minutes, p = 0.001). Black patients had a shorter median hospital length of stay than White patients (15 days versus 18 days, p < 0.031). There was a small but statistically significant difference in modified Fisher score between black and white patients (3.48 versus 3.17, p = 0.04). There were no significant racial differences present in sex, Hunt Hess grade, discharge disposition, complications, or need for further interventions. Conclusion Black race was associated with higher blood pressure at presentation, longer time to blood pressure control, but shorter hospital length of stay. No racial differences were present in aneurysmal subarachnoid hemorrhage associated complications or interventions.
Linearization stability of the Einstein equation for Robertson–Walker models. II

In a previous paper (referred to here as paper I) we showed that the Einstein equation is linearization stable when a Robertson–Walker model of curvature K=0 is considered. For that purpose, a slightly different definition of linearization stability was introduced. In this paper we show that in case the curvature K is equal to 1 the Einstein equation G(g)=χT is not linearization stable at the Robertson–Walker metric.
Psychometric Properties of the Access of Older Adults to Outpatient Primary-Care Health Services Scale

This study evaluates the psychometric properties of the Access of Older Adults to Outpatient Primary-Care Health Services Scale (AOAOPHSS), in research conducted among 707 Mexican older adults selected by convenience from 14 rural and one urban locations. The AOAOPHSS explores 10 dimensions of two integrated subscales: Accessibility and Personal Abilities. Data analysis was performed in five phases. First, potentially biased responses were identified. Second, the response efficiency of the items and their association with external variables were evaluated. Third, the basic properties of the scores for the subscales’ dimensions of the AOAOPHSS were identified using non-parametric Mokken Scaling Analysis (MSA). Fourth, the Structural Equation Modeling methodology was used to identify the properties of the internal structure of the latent construct. Finally, reliability and internal consistency were evaluated at both score and item levels. The following findings emerged. 13 items with inefficient response options were removed, and 24 were retained using the MSA. The latent structure of the latter was defined based on 21 items of five Accessibility Subscale dimensions. Its internal consistency reliability ranged between 0.67 and 0.81 (omega coefficients) and between 0.61 and 0.78 (alpha coefficients). Accordingly, this paper discusses the overall implications of using the Accessibility Subscale.
Random matrix models with additional interactions

It has been argued that, despite remarkable success, existing random matrix theories are not adequate at describing disordered conductors in the metallic regime, due to the presence of certain two-body interactions in the effective Hamiltonian for the eigenvalues, in addition to the standard logarithmic interaction that arises entirely from symmetry considerations. We present a new method that allows exact solution of random matrix models with such additional two-body interactions. This should broaden the scope of random matrix models in general.
Decoding the phonon transport of structural lubrication at silicon/silicon interface

Although the friction characteristics under different contact conditions have been extensively studied, the mechanism of phonon transport at the structural lubrication interface is not extremely clear. In this paper, we firstly promulgate that there is a 90°-symmetry of friction force depending on rotation angle at Si/Si interface, which is independent of normal load and temperature. It is further found that the interfacial temperature difference under incommensurate contacts is much larger than that in commensurate cases, which can be attributed to the larger interfacial thermal resistance (ITR). The lower ITR brings greater energy dissipation in commensurate sliding, and the reason for that is more effective energy dissipation channels between the friction surfaces, making it easier for the excited phonons at the washboard frequency and its harmonics to transfer through the interface. Nevertheless, the vibrational frequencies of the interfacial atoms between the tip and substrate during the friction process do not match in incommensurate cases, and there is no effective energy transfer channel, thus presenting the higher ITR and lower friction. Eventually, the number of excited phonons on contact surfaces reveals the amount of frictional energy dissipation in different contact states.
Finite-size scaling in the (2+1)D Ising model

Hamiltonian eigenvalues are calculated for the (2+1)D Ising model on lattices up to 5*5 sites. Finite-size scaling techniques are used to estimate the critical coupling xc=0.329+or-0.001, and index v=0.635+or-0.005. The prospects are discussed for further applications of these methods in three and four dimensions.
An arbitrary Lagrangian–Eulerian method based on the adaptive Riemann solvers for general equations of state

Approximate or exact Riemann solvers play a key role in Godunov‐type methods. In this paper, three approximate Riemann solvers, the MFCAV, DKWZ and weak wave approximation method schemes, are investigated through numerical experiments, and their numerical features, such as the resolution for shock and contact waves, are analyzed and compared. Based on the analysis, two new adaptive Riemann solvers for general equations of state are proposed, which can resolve both shock and contact waves well. As a result, an ALE method based on the adaptive Riemann solvers is formulated. A number of numerical experiments show good performance of the adaptive solvers in resolving both shock waves and contact discontinuities. Copyright © 2008 John Wiley & Sons, Ltd.