Miracle-dz/UniFAR-FTUs huggingface dataset:
A Controls upon the Last Glacial Maximum deglaciation of the northern Ice Stream System,

The Uummannaq ice stream system (UISS) was a convergent cross-shelf ice stream system that operated in West Greenland during the Last Glacial Maximum (LGM). This paper presents new evidence constraining the geometry and evolution of the northern sector of the UISS and considers the factors controlling its dynamic behaviour. Geomorphological mapping, 21 new terrestrial cosmogenic nuclide (TCN) exposure ages, and radiocarbon dating constrain LGM warm-based ice stream activity in the north of the system up to 1400 m a.s. l. Intervening plateaux areas either remained ice free, or were covered by cold-based icefields. Beyond the inner fjords, topography and bathymetry forced ice flow southwards into the Uummannaq Trough, where it coalesced with ice from the south, and formed the trunk zone of the UISS. Deglaciation of the UISS began at 14.9 cal. kyr BP. Rapid retreat from the LGM limit was forced by an increase in air temperatures and rising sea level, enhanced by the bathymetric over-deepening of the Uummannaq and Igdlorssuit Sund troughs. Ice reached the inner fjord confines in the northern Uummannaq area by Maximum (~11 – 5 kyr) is in direct contrast to records of other ice streams throughout West Greenland, which suggest ice had retreated beyond its present margin by 9-7 kyr. This demonstrates the potential importance of topographic control on calving margin stability, and its ability to override climatic forcing.
The Multiple Myeloma SET Domain (MMSET) Protein is a Histone Methyltransferase with Characteristics of a Transcriptional Co-repressor

MMSET, identified by its fusion to the IgH locus in t(4;14) associated multiple myeloma, posses domains found within chromatin regulators including the SET domain. MMSET protein is overexpressed and tighly associated with chromatin in myeloma cell lines carrying t(4;14). MMSET possesses methyltransferase activity for core histone H3 lysine 4 and histone 4 lysine 20; while MMSET made in cells only modified H4. Segments of MMSET fused to the Gal4 DNA binding domain repressed transcription of a chromatin–embedded Gal4 reporter gene. MMSET-mediated repression was associated with increased H4K20 methylation gene and loss of histone acetyaltion. Consistent with this repressive activity, MMSET could form a complex with HDAC1 and HDAC2, mSin3a and the histone demethylase LSD1 suggesting that it is a component of co-repressor complexes. Furthemore MMSET co-expression enhances HDAC1 and HDAC2-mediated repression in transcriptional reporter assays. Finally shRNA mediated knockdown of MMSET compromised viability of a myeloma cell line suggesting a biological role for the protein in malignant cell growth. Collectively, these data suggest that by acting directly as a modifier of chromatin as well as through binding of other chromatin modifying enzymes, MMSET influences gene expression and potentially acts as a pathogenic agent in multiple myeloma. proteins. The cells were harvested 48 h later and assayed for luciferase activity using a Dual Reporter Luciferase Assay Kit (Promega). The results obtained were normalized for protein concentration from each well of transfected cells. Myeloma cell lines were transduced using an Amaxa nucleoporator. 5 x 10 6 cells were incubated in solution T and 5 ug of shRNA plasmid and transduced using program T20. At 3 and 5 days after transfection, transduced cells were stained with Texas red-conjugated annexin V (Clontech) and propidium iodide and analyzed by flow cytometery (LSR-II, Becton Dickenson). To determine the extent of shRNA knockdown, transduced cells were sorted (FACSort, Becton Dickinson) and total cell lystaes were immunoblotted for MMSET. to significantly elevated levels of the corresponding proteins. All the t(4;14) myeloma cell lines we tested overexpress either the full-length MMSET-II protein or the shorter variants MB4-2 II and MB4-3 II, which lack different portions of the amino terminus but carry an intact carboxyl terminus and SET domain. Prior work showed that green fluorescent protein (GFP)-tagged MMSET-I and II localized to the nucleus but not nucleoli, whereas the MB4-2 and MB4-3 proteins concentrate in nucleoli 23 . Examining of the pattern
of Productivity in and Fiscal Volatility, Financial Crises and Growth

We use a panel of developed and emerging countries for the period 1970-2008 to assess how fiscal policy volatility and financial crises affect growth. We find that economic growth is lower in the presence of more volatile fiscal policy. Moreover, with a financial crisis government spending is stickier than revenue. JEL: C23, E62, H50.
SIX WEEKS OF A POLARISED TRAINING INTENSITY DISTRIBUTION LEADS TO GREATER 1 PHYSIOLOGICAL AND PERFORMANCE ADAPTATIONS THAN A THRESHOLD MODEL IN TRAINED 2 CYCLISTS 3

33 Aim: To investigate physiological adaptation with two endurance training periods differing in 34 intensity distribution. Methods: In a randomised cross-over fashion, separated by 4-weeks of 35 detraining, 12 male cyclists completed two 6-week training periods: (1) a polarised model 36 (6.4(±1.4)hrs . week -1 ; 80%, 0%, 20% of training time in low, moderate and high intensity zones); and 37 (2) a threshold model (7.5(±2.0)hrs . week -1 ; 57%, 43%, 0% training intensity distribution). Before and 38 after each training period, following 2 days of diet and exercise control, fasted skeletal muscle 39 biopsies were obtained for mitochondrial enzyme activity and monocarboxylate transporter 40 (MCT1/4) expression, and morning first void urine samples collected for NMR spectroscopy based 41 metabolomics analysis. Endurance performance (40km time trial), incremental exercise, peak power 42 output, and high-intensity exercise capacity (95% Wmax to exhaustion) were also assessed. Results: 43 Endurance performance, peak power output, lactate threshold, MCT4, and high-intensity exercise 44 capacity all increased over both training periods. Improvements were greater following polarised 45 than threshold for peak power output (Mean (±SEM) change of 8(±2)% vs. 3(±1)%, P<0.05), lactate 46 threshold (9(±3)% vs. 2(±4)%, P<0.05), and high-intensity exercise capacity (85(±14)% vs. 37(±14)%, 47 P<0.05). No changes in mitochondrial enzyme activities or MCT1 were observed following training. A 48 significant multi-level partial least squares-discriminant analysis model was obtained for the 49 threshold model but not the polarised model in the metabolomics analysis. Conclusion : A polarised 50 training distribution results in greater systemic adaptation over 6 weeks in already well-trained 51 cyclists. Markers of muscle metabolic adaptation are largely unchanged but metabolomics markers 52 suggest different cellular metabolic stress that requires further investigation.
Inhibition of human gastric H 1 -K 1 -ATPase a -subunit gene expression by Helicobacter pylori

Inhibition of human gastric H 1 -K 1 -ATPase a -subunit gene expression by Helicobacter pylori. Am J Physiol Gastrointest Liver Physiol 278: G981–G991, 2000. —Clinical studies and in vitro data from isolated parietal cells suggest that acute Helicobacter pylori infection inhibits acid secretion. Gastric acidiﬁcation is mediated by H 1 -K 1 -ATPase, an integral protein of parietal cell apical membranes. To test the hypothesis that H. pylori downregulates H 1 -K 1 -ATPase a -subunit (HK a ) gene expression and to identify potential intracellular signaling pathways mediating such regulation, we transfected human gastric adenocarcinoma (AGS) cells with human and rat HK a 5 8 -ﬂanking DNA fused to a luciferase reporter plasmid. Histamine caused dose-dependent, cimetidine-sensitive (10 2 4 M) increases in cAMP, free intracellular Ca 2 1 , and HK a promoter activation in AGS cells. H. pylori infection of transfected AGS cells dose dependently inhibited basal and histamine-stimulated HK a promoter activity by 80% and 66%, respectively. H. pylori dose dependently inhibited phorbol myristate acetate-induced (10 2 7 M) and staurosporine-(10 2 7 M) and calphostin C-sensitive (5 3 10 2 8 M) activation of HK a promoter. Also, H. pylori inhibited epidermal growth factor (EGF) (10 2 8 M), genistein-sensitive (5 3 10 2 5 M) activation of HK a promoter, reducing activity to 60% of basal level. These data suggest that H. pylori inhibits HK a gene expression via intracellular pathways involving protein kinases A and C and protein tyrosine kinase, AGS cells have functional histamine H 2 and EGF receptors, and transiently transfected AGS cells are a useful model for studying regulation of HK a gene expression.
15 MYA of evolution in the Oryza genus shows extensive gene family expansion

In analyzing gene families in the whole genome sequences available for O. sativa (AA), O. glaberrima (AA) and O. brachyantha (FF), we observed large size expansion in the AA genomes compared to FF genomes for the super-families F-box and NB-ARC, and 5 additional families: the Aspartic proteases, BTB/POZ proteins, Glutaredoxins, Trypsin α-amylase inhibitor proteins, and Zf-Dof proteins. Their evolutionary dynamic was investigated to understand how and why such important size variations are observed between these closely-related species. We show that expansions resulted from both amplification, largely by tandem duplications, and contraction by genes losses. For the F-box and NB-ARC gene families, the genes conserved in all species were under strong purifying selection while expanded orthologous genes were under more relaxed purifying selection. In F-box, NB-ARC and BTB, the expanded groups were enriched in genes with little evidence of expression, in comparison with conserved groups. We also detected 87 loci under positive selection in the expanded groups. These results show that most of the duplicated copies in the expanded groups evolve neutrally after duplication because of functional redundancy but a fraction of these genes were preserved following neofunctionalization. Hence the lineage-specific expansions observed between Oryza species were partly driven by directional selection. ; ;
Geomorphology and Prehistoric Settlements on a Volcanic Island: the Case of Ustica (Palermo, Italy)

This study represents the first attempt to combine the geomorphological characteristics of the island of Ustica with the human settlements that have been established during prehistory, with the purpose of reconstructing the interactions between communities and the natural environment from the Neolithic to the Middle Bronze Age (6 th - 1 st millennia B.C.). Ustica is a small island in the Southern Tyrrhenian Sea, visible but far ( ~ 55 km) from the northern coast of western Sicily. Its rugged volcanic nature, remodeled and enriched by the sea, offered to the first colonizers a wide repertoire of opportunities and challenges. This island can be treated as an ideal “laboratory” to understand how settlers, taking their first steps towards the foundation of organized communities, were able to seize opportunities or succumb to obstacles. The review of archaeological research until now carried out in Ustica, integrated with geomorphological data and other biogeographical indicators, offers a picture of the prehistory of Ustica in which human presence is continuous and distributed in various sites of the island characterized by different physiographic characteristics. There are phases dominated by the choice of naturally protected sites and phases in which settlements expands on open land, suitable for agricultural use. Where the archaeological evidence is scarce, the geomorphological peculiarities allow us to decipher the vocations and characters of a human settlement. The study leads to an open question: in the Middle Bronze Age, after about five thousand years of uninterrupted habitation of Ustica, which factors, geological, social, or other, induced the early communities to abandon the island, without returning there for about eight centuries, until the Hellenistic-Roman age?
Segmentation and recognition of �led sweet pepper based on improved self-attention convolutional neural networks

Automatic and accurate recognition of the parts to be picked is the key to realize the intelligent picking of sweet pepper. However, pepper fruits are always covered by other organs, and small objects like stems and shoots are di�cult to be recognized by machines or cameras under certain extreme conditions. To accurately segment and recognize all kinds of objects in sweet pepper images captured at night, three experiments were performed in this paper, and an enhanced model based on convolutional neural networks (CNNs) was eventually achieved. In experiment I, several semantic segmentation networks were trained on a small dataset, and the full-resolution residual network (FRRN) was taken as a primary network. Then, the impact of resolution of input images on the segmentation effect was investigated in experiment II. In order to strengthen the feature presentation of inconspicuous objects, the position attention module (PAM) was appended on top of the FRRN in experiment III. This architecture was further trained to provide more precise segmentation results. The experimental result shows that the mean intersection over union (IoU) is 78.88%, which is at least 1.94 percentage points higher than other models, and the mean pixel accuracy (PA) is 97.94% on the test set. The proposed method has higher generalization performance when facing unforeseen picking situations, meanwhile it is generic and can be applied to other fruits and vegetables.
High temperature, harsh environment sensors for advanced power generation systems

One mission of the Crosscutting Technology Research program at the National Energy Technology Laboratory is to develop a suite of sensors and controls technologies that will ultimately increase efficiencies of existing fossil-fuel fired power plants and enable a new generation of more efficient and lower emission power generation technologies. The program seeks to accomplish this mission through soliciting, managing, and monitoring a broad range of projects both internal and external to the laboratory which span sensor material and device development, energy harvesting and wireless telemetry methodologies, and advanced controls algorithms and approaches. A particular emphasis is placed upon harsh environment sensing for compatibility with high temperature, erosive, corrosive, and highly reducing or oxidizing environments associated with large-scale centralized power generation. An overview of the full sensors and controls portfolio is presented and a selected set of current and recent research successes and on-going projects are highlighted. A more detailed emphasis will be placed on an overview of the current research thrusts and successes of the in-house sensor material and device research efforts that have been established to support the program.
Chiral Symmetry Restoration and the sigma-meson

The sigma-meson, which is at best a broad resonance in the vacuum, may suffer a substantial red-shift and appear as a soft and narrow collective mode at finite temperature and baryon densities. The physics behind this softening phenomena and its relation to the partial restoration of chiral symmetry are discussed. Possible experiments in laboratory to test the idea are also summarized.
SPINS OF LARGE ASTEROIDS: A HINT OF A PRIMORDIAL DISTRIBUTION IN THEIR SPIN RATES

The Asteroid Belt and the Kuiper Belt are relics from the formation of our solar system. Understanding the size and spin distribution of the two belts is crucial for a deeper understanding of the formation of our solar system and the dynamical processes that govern it. In this paper, we investigate the effect of collisions on the evolution of the spin distribution of asteroids and KBOs. We find that the power law nature of the impactors’ size distribution leads to a Lévy distribution of the spin rates. This results in a power law tail in the spin distribution, in stark contrast to the usually quoted Maxwellian distribution. We show that for bodies larger than 10 km, collisions alone lead to spin rates peaking at 0.15–0.5 revolutions per day. Comparing that to the observed spin rates of large asteroids (R > 50 km), we find that the spins of large asteroids, peaking at ∼1–2 revolutions per day, are dominated by a primordial component that reflects the formation mechanism of the asteroids. Similarly, the Kuiper Belt has undergone virtually no collisional spin evolution, assuming current densities. Collisions contribute a spin rate of ∼0.01 revolutions per day, thus the observed fast spin rates of KBOs are also primordial in nature.
Association between Helicobacter pylori Virulence Factors and Gastroduodenal Diseases in Okinawa, Japan AUTHOR’S CORRECTION

29 The incidence of gastric cancer in Okinawa is the lowest in Japan. Some previous reports 30 using small number of strains suggest that the high prevalence of Helicobacter pylori with 31 Western-type cagA in Okinawa compared with other areas in Japan might contribute to the 32 low incidence of gastric cancer. It has still not been confirmed why the prevalence of 33 Western-type cagA strains is high in Okinawa. We examined the association between the 34 virulence factors of H. pylori and gastroduodenal diseases in Okinawa. The genotypes of 35 cagA and vacA of 337 H. pylori strains were determined by polymerase chain reaction and 36 gene sequencing. The genealogy of these Western-type cagA strains in Okinawa was 37 analyzed by multi-locus sequence typing (MLST). Overall, 86.4% of strains possessed cagA : 38 70.3 % were East-Asian-type and 16.0 % were Western-type. After adjustment by age and sex, 39 the presence of East-Asian-type cagA / vacA s1m1 genotypes was significantly associated with 40 gastric cancer compared with gastritis (Odds Ratio = 6.68, 95 % Confidence Interval = 41 1.73-25.8). The structure of Western-type CagA in Okinawa was different from that of typical 42 Western-type CagA found in Western countries. Intriguingly, MLST analysis revealed that the 43 majority of Western-type cagA strains formed individual clusters but not hpEurope. Overall, 44 low prevalence of gastric cancer in Okinawa may result from the high prevalence of non 45 East-Asian-type cagA strains. The origin of Western-type cagA strains in Okinawa can be 46 different from those of Western countries. 47
Nonparametric methods in change-point problems: a general approach and some concrete algorithms

A general approach to change-point problems is proposed. This approach is based upon two ideas. The first idea is that any change-point problem can be reduced to the problem of detection of changes in the mean value of some new sequences. The second idea is that the nonparametric family of Kolmogorov-Smirnov type statistics can be used for change-point detection in these sequences. This general approach is implemented in two cases: (a) the problem of gradual change-point detection, and (b) change-point detection in two-phase regression model.
IMPACT OF SEASONAL VARIABILITY ON PHENOLOGICAL DEVELOPMENT AND PRODUCTIVITY OF MUNGBEAN ( VIGNA RADIATA (L.) R. WILCZEK) IN ARID CLIMATIC CONDITION

Mungbean is an important legume in arid regions that is under threat due to changing rainfall conditions and temperature fluctuations in the region. These risks can be addressed by optimizing sowing time and selecting the right mungbean cultivars. Therefore, the present study was conducted during summer seasons of 2018 and 2019 to reveal the best sowing time for mung bean genotypes. Experiment was comprised of two factors i.e., sowing dates; 1 st April, 15 th April, 1 st May and 15 th May, and genotypes, Bahawalpur-mung-2017, NIAB-mung-2016 and AZRI-mung-2006. NIAB-mung-2016 sown at 1 st April during 2018 and 2019 took higher days to complete the phenological stages as well as gave higher viable pollens (79.63 and 73.40%), chlorophyll contents (50.11 and 47.04 µg cm 2 ) number of pods/plant (38.13 and 30.32), number of seed/pod (14.20 and 11.67), 1000-seed weight (53.21 g), grain yield (1856 and 1585 Kg ha -1 ), biological yield (5940 and 5335 Kg ha -1 ) and harvest index (31.45 and 28.04%). Likewise higher heat use efficiency, heat thermal unit, relative temperature depression were also recorded when mungbean was sown at 1 st April during 2018 and 2019. Hence it is concluded that NIAB-mung-2016 sown at 1 st April had the potential to increase mungbean productivity under arid conditions. plants were to calculate grain and harvest index was calculated by dividing grain yield into biological yield. From the grains produced in each 1000-seeds were and to 1000-seed
CORDIC-SNN: On-FPGA STDP Learning With Izhikevich Neurons

This paper proposes a neuromorphic platform for on-FPGA online spike timing dependant plasticity (STDP) learning, based on the COordinate Rotation DIgital Computer (CORDIC) algorithms. The implemented platform comprises two main components. First, the Izhikevich neuron model is modified for implementation using the CORDIC algorithm, simulated to ensure the model accuracy, described as hardware, and implemented on FPGA. Second, the STDP learning algorithm is adapted and optimized using the CORDIC method, synthesized for hardware, and implemented to perform on-FPGA online learning on a network of CORDIC Izhikevich neurons to demonstrate competitive Hebbian learning. The implementation results are compared with the original model and state-of-the-art to verify accuracy, effectiveness, and higher speed of the system. These comparisons confirm that the proposed neuromorphic system offers better performance and higher accuracy while being straightforward to implement and suitable to scale.
Effectiveness of convalescent plasma therapy for COVID-19 patients infected with variants of concerns

COVID-19 cases in Indonesia seemed to be increasing by each passing day at the time of writing this review, more positive cases discovered than the recovered ones. With the highest rank within all ASEAN countries, and also a home of many variants of COVID-19, Indonesia had become a break off destination to others. Along with the problem associated with the pandemic, which all people had to face, the purpose of this review is to elaborate the use of convalescent plasma therapy on treatment against COVID-19, especially its different variants. We overview the evidence that we obtained from several databases using specific keywords. A large amount of evidence points out that the convalescent plasma therapy has shown a promising outcome against COVID-19 infection, as it did for infectious diseases. Although in COVID-19 variants of concern, convalescent plasma therapy showed a reduction in neutralization ~ 3-fold against P.1, and 7-13 folds against B.1. 351 variant, it still can be used as a treatment for COVID-19 and its variants. Abbreviations: PPE - personal protective equipment; VoC - Variants of concern; VoI - Variants of interest; CPT - convalescent plasma therapy; RBD - receptor-binding domain; ARDS - Acute Respiratory Distress Syndrome; ICU - Intensive Care Unit; IQR - Interquartile Range; RCT - Randomized Clinical Trial; RT-PCR - Reverse Transcriptase-Polymerase Chain Reaction; NAbs - neutralizing antibodies Key words: Convalescent plasma therapy; COVID-19, Variants of Concern Citation: Kurniawati EM, Putri IS, Widiatmaja DM, Praba VM, Visuddho 2, Prameswari FU, Zahrani M, Putra FN, Nugraha D, Widiastara AA. Effectiveness of convalescent plasma therapy for COVID-19 patients infected with variants of concerns. Anaesth. pain intensive care 2022;26(4):535-545; DOI: 10.35975/apic.v26i4. 1962 Received: July 31, 2021; Reviewed: May 17, 2022; Accepted: May 18, 2022