Miracle-dz/UniFAR-FTUs huggingface dataset:
Arctic Oscillation response to the 1991 Mount Pinatubo eruption: Effects of volcanic aerosols and ozone depletion

[1] Observations show that strong equatorial volcanic eruptions have been followed by a pronounced positive phase of the Arctic Oscillation (AO) for one or two Northern Hemisphere winters. It has been previously assumed that this effect is forced by strengthening of the equator-to-pole temperature gradient in the lower stratosphere, caused by aerosol radiative heating in the tropics. To understand atmospheric processes that cause the AO response, we studied the impact of the 1991 Mount Pinatubo eruption, which produced the largest global volcanic aerosol cloud in the twentieth century. A series of control and perturbation experiments were conducted with the GFDL SKYHI general circulation model to examine the evolution of the circulation in the 2 years following the Pinatubo eruption. In one set of perturbation experiments, the full radiative effects of the observed Pinatubo aerosol cloud were included, while in another only the effects of the aerosols in reducing the solar flux in the troposphere were included, and the aerosol heating effects in the stratosphere were suppressed. A third set of perturbation experiments imposed the stratospheric ozone losses observed in the post-Pinatubo period. We conducted ensembles of four to eight realizations for each case. Forced by aerosols, SKYHI produces a statistically significant positive phase of the AO in winter, as observed. Ozone depletion causes a positive phase of the AO in late winter and early spring by cooling the lower stratosphere in high latitudes, strengthening the polar night jet, and delaying the final warming. A positive phase of the AO was also produced in the experiment with only the tropospheric effect of aerosols, showing that aerosol heating in the lower tropical stratosphere is not necessary to force positive AO response, as was previously assumed. Aerosol-induced tropospheric cooling in the subtropics decreases the meridional temperature gradient in the winter troposphere between 30°N and 60°N. The corresponding reduction of mean zonal energy and amplitudes of planetary waves in the troposphere decreases wave activity flux into the lower stratosphere. The resulting strengthening of the polar vortex forces a positive phase of the AO. We suggest that this mechanism can also contribute to the observed long-term AO trend being caused by greenhouse gas increases because they also weaken the tropospheric meridional temperature gradient due to polar amplification of warming.
Detection of higher frequency components at mid-QRS stage of electrocardiogram-a digital filtering approach and its possible relevance to myocardial tissue characterization

In order to detect very minute energy, if any, of higher frequency range at the mid-QRS stage of an electrocardiographic signal, frequency domain analysis and three-dimensional presentation of its outcome were carried out. A simulation-averaged electrocardiographic signal underwent digital filtering using techniques of narrow band-passing characteristics. The set of frequency component curves with stepwise increasing center frequency of band-passing was normalized so that higher frequency components with very low energy were especially emphasized. The higher frequency components at the mid-QRS stage were clearly present with special features (plural peaks on frequency component curves) in many of the patient groups with coronary heart disease and in none with such features among the normals, indicating the possible usefulness of this approach for electrical 'tissue characterization' of cardiac muscles. <<ETX>>
Development of Tritium Technologies at KAERI

Abstract Tritium is formed by neutrons captured from deuterium. If left to accumulate, tritium oxide will become a hazard to the operating staff and public. The primary purpose of a Tritium Removal Facility (TRF) is to reduce tritium concentration in a heavy water moderator. In Korea, operation of a TRF commenced at the Wolsong Nuclear Power Site on July 26th, 2007. Nowadays, KAERI is developing a Very High Temperature Gas Cooled Reactor (VHTR). We have developed a tritium behavior analysis code for the VHTR. We also developed analytical methods for the measurement of food stuffs. Korea shared in the construction of the ITER fuel cycle plant with the EU, Japan, and the US, and is responsible for the supply of an SDS (Tritium Storage and Delivery System). We present the recent progress in the development of tritium storage technology, and safety features of the related system. KAERI has been developing tritium technologies related to the Wolsong TRF, HANARO, VHTR, and nuclear fusion fuel systems. We thus present details on the recent development progress of these tritium systems.
Differential-Fed Dual-Polarized Filtering Fabry-Perot Antenna With High Isolation

In this paper, a dual-polarized filtering Fabry-Perot antenna (FPA) with high-isolation is proposed. It consists of a feed element of differential-fed dual-polarized square patch and a partially reflecting surface (PRS). The patch is capacitively coupled with T-shaped resonators and shorting-vias to obtain broadband characteristic and radiation nulls. The PRS structure is composed of two complementary metasurface layers, which are selected for achieving a positive reflection phase gradient within the broad frequency range. More interestingly, thanks to the frequency selectivity feature, the PRS significantly enhances the filtering characteristic of the FPA. For verification, a prototype of the proposed antenna operating at the 5.5-GHz center frequency has been fabricated and measured. The prototype with an overall size of <inline-formula> <tex-math notation="LaTeX">$\sim 2.0\lambda _{\text {min}} \times 2.0\lambda _{\text {min}} \times 0.49\lambda _{\text {min}}$ </tex-math></inline-formula> (<inline-formula> <tex-math notation="LaTeX">$\lambda _{\text {min}}$ </tex-math></inline-formula> is the free-space wavelength referring to the lowest operational frequency) result in an impedance bandwidth of 17.1% (<inline-formula> <tex-math notation="LaTeX">$5.02-5.96$ </tex-math></inline-formula> GHz) for 10-dB return loss and a high isolation of <inline-formula> <tex-math notation="LaTeX">$\ge45$ </tex-math></inline-formula> dB. Moreover, the far-field measurements result in a good dual-polarized radiation with the peak gain of 13.0 dBi, cross-polarization level of <inline-formula> <tex-math notation="LaTeX">$\le $ </tex-math></inline-formula>–25 dB within the passband, and out-of-band suppression level of <inline-formula> <tex-math notation="LaTeX">$\ge20$ </tex-math></inline-formula> dB.
Saari's Conjecture and Variational Minimal Solutions for $N$-Body Problems

In this paper, we will prove Saari's conjecture in a particular case by using a arithmetic fact, and then, apply it to prove that for any given positive masses, the variational minimal solutions of the N-body problem in ${\mathbb{R}}^2$ are precisely a relative equilibrium solution whose configuration minimizes the function $IU^2$ in ${{\mathbb{R}}}^2$.
Galaxy Masses: A Review

Galaxy masses play a fundamental role in our understanding of structure formation models. This review addresses the variety and reliability of mass estimators that pertain to stars, gas, and dark matter. The dierent sections on masses from stellar populations, dynamical masses of gas-rich and gas-poor galaxies, with some attention paid to our Milky Way, and masses from weak and strong lensing methods, all provide review material on galaxy masses in a self-consistent manner. Keywords: galaxies: dark matter | galaxies: evolution | galaxies: formation
How Does Digitalization Affect Haze Pollution? The Mediating Role of Energy Consumption

In the context of digital technology innovation, an in-depth investigation into the impact of digitalization on haze pollution is of great significance for scientifically understanding environmental effects of digitalization and building a livable civic environment. From the perspective of energy consumption intensity and structure, this paper theoretically analyzes the direct and indirect effects of digitalization on haze pollution. On this basis, the impact of digitalization on haze pollution for 81 countries over the period 2010–2019 is empirically investigated by using the system GMM and mediating effects model. Empirical results show that digitalization can effectively suppress haze pollution, and there is significant heterogeneity in this inhibiting effect. In addition, digitalization can indirectly restrain haze pollution by reducing energy consumption intensity and optimizing energy consumption structure. The findings of this paper can provide enlightenment for countries to promote digitalization, combat haze pollution, and thus enhance the health of community residents.
The Correlations of Minimal Inhibitory Concentration Values of Anti-TB Drugs with Treatment Outcomes and Clinical Profiles in Patients with Multidrug-Resistant Tuberculosis (MDR-TB) in China

Objective It is a challenge to obtain satisfactory treatment outcomes for patients with multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB); the study aims to correlate the Minimum Inhibitory Concentration (MIC) value of drugs with the outcome of patients with MDR/RR-TB to obtain an understanding for better regimens and optimal outcomes. Methods The patients diagnosed with MDR/RR-TB were retrospectively enrolled from January 1, 2018 to December 31, 2019, recorded clinical characteristics, MIC DST (Drug Susceptibility Test) results, and followed the treatment outcome. The data were analyzed on the correlations of MIC DST values with outcomes and clinical characteristics. Results A total of 276 patients with MDR/RR-TB were included, containing 98 cases (35.5%) with newly treated patients and 178 cases (64.5%) with re-treated patients. A total of 220 cases recorded treatment success (79.7%) and 49 cases recorded treatment failure or died. MIC values of isoniazid (H), moxifloxacin (Mfx), and ethionamide (Eto) in newly treated patients were lower than those in retreated patients, and resistance levels of Mfx and H were closely associated with the treatment outcome (P < 0.05) while those of other drugs had no close association with treatment outcome. Conclusions MIC values of some anti-TB drugs, such as fluoroquinolones (FQs) and H, can reflect the treatment outcome for patients with MDR/RR-TB, which can contribute to making regimens for better treatment outcomes.
Organizational Culture and Impact on Improving Employee Performance

The policy of the management in the organization is to introduce organizational culture to its employees which will help employees to get to know the organizational system as a whole and integrated with work behavior. A proper understanding of organizational culture must lead to an increase in employee performance and is a contribution to the realization of organizational goals. Organizational culture needs to be developed in such a way as to improve employee performance and continuously develop quality awareness. Thus, the purpose of this study is to analyze and determine the influence of organizational culture on employee performance. The research was conducted in a small business that trades through online media and has 17 employees. The data analysis technique used a simple regression test. The results of this study mostly show a positive relationship between a strong culture and improved performance. Based on this research, it can be concluded that organizational culture has a positive and significant effect on employee performance.
Promoting Immortalized Adipose-Derived Stem Cell Transdifferentiation and Proliferation into Neuronal-Like Cells through Consecutive 525 nm and 825 nm Photobiomodulation

Neuronal cells can be generated from adipose-derived stem cells (ADSCs) through biological or chemical inducers. Research has shown that this process may be optimized by the introduction of laser irradiation in the form of photobiomodulation (PBM) to cells. This in vitro study is aimed at generating neuronal-like cells with inducers, chemical or biological, and at furthermore treating these transdifferentiating cells with consecutive PBM of a 525 nm green (G) laser and 825 nm near-infrared (NIR) laser light with a fluence of 10 J/cm2. Cells were exposed to induction type 1 (IT1): 3-isobutyl-1-methylxanthine (IBMX) (0.5 mM)+indomethacin (200 μM)+insulin (5 μg/ml) for 14 days, preinduced with β-mercaptoethanol (BME) (1 mM) for two days, and then incubated with IT2: β-hydroxyanisole (BHA) (100 μM)+retinoic acid (RA) (10-6 M)+epidermal growth factor (EGF) (10 ng/ml)+basic fibroblast growth factor (bFGF) (10 ng/ml) for 14 days and preinduced with β-mercaptoethanol (BME) (1 mM) for two days and then incubated with indomethacin (200 μM)+RA (1 μM)+forskolin (10 μM) for 14 days. The results were evaluated through morphological observations, viability, proliferation, and migration studies, 24 h, 48 h, and 7 days post-PBM. The protein detection of an early neuronal marker, neuron-specific enolase (NSE), and late, ciliary neurotrophic factor (CNTF), was determined with enzyme-linked immunosorbent assays (ELISAs). The genetic expression was also explored through real-time PCR. Results indicated differentiation in all experimental groups; however, cells that were preinduced showed higher proliferation and a higher differentiation rate than the group that was not preinduced. Within the preinduced groups, results indicated that cells treated with IT2 and consecutive PBM upregulated differentiation the most morphologically and physiologically.
Multiscale Kinetic Monte Carlo Simulation of Self-Organized Growth of GaN/AlN Quantum Dots

A three-dimensional kinetic Monte Carlo methodology is developed to study the strained epitaxial growth of wurtzite GaN/AlN quantum dots. It describes the kinetics of effective GaN adatoms on an hexagonal lattice. The elastic strain energy is evaluated by a purposely devised procedure: first, we take advantage of the fact that the deformation in a lattice-mismatched heterostructure is equivalent to that obtained by assuming that one of the regions of the system is subjected to a properly chosen uniform stress (Eshelby inclusion concept), and then the strain is obtained by applying the Green’s function method. The standard Monte Carlo method has been modified to implement a multiscale algorithm that allows the isolated adatoms to perform long diffusion jumps. With these state-of-the art modifications, it is possible to perform efficiently simulations over large areas and long elapsed times. We have taylored the model to the conditions of molecular beam epitaxy under N-rich conditions. The corresponding simulations reproduce the different stages of the Stranski–Krastanov transition, showing quantitative agreement with the experimental findings concerning the critical deposition, and island size and density. The influence of growth parameters, such as the relative fluxes of Ga and N and the substrate temperature, is also studied and found to be consistent with the experimental observations. In addition, the growth of stacked layers of quantum dots is also simulated and the conditions for their vertical alignment and homogenization are illustrated. In summary, the developed methodology allows one to reproduce the main features of the self-organized quantum dot growth and to understand the microscopic mechanisms at play.
Simulations of hydrogel-coated neural microelectrodes to assess biocompatibility improvement using strain as a metric for micromotion

This study investigates the benefit of coating silicon-substrate microelectrode arrays with hydrogel material for improved biocompatibility. Varying coating thicknesses and hydrogel material descriptions were considered to determine the impact on reducing strain in the surrounding brain tissue caused by relative micromotion of the electrode. Finite element simulations were used to explore biocompatibility by focusing on the longitudinal micromotion of an implanted single electrode shank. The finite element model for the brain and electrode, both with and without the hydrogel coating, remained constant. Three constitutive models were considered to describe the brain and/or hydrogel material: linear elastic, hyperviscoelastic, and fractional Zener. All combinations of these three material descriptions were explored. The simulation results showed that the constitutive model, electrode coating thickness, and the degree of microelectrode adhesion to the brain influenced the maximum principal logarithmic strain and also the maximum electrode displacement. Biocompatibility was improved as evidenced by a reduction in the magnitude of strain in the brain when (i) a hydrogel coating was applied to the silicon electrode, (ii) the thickness of the hydrogel coating was increased, and (iii) the brain adhered completely to the hydrogel coating. A decrease in microelectrode displacement may be a useful metric for assessing an improvement in micromotion reduction.
Spatial Distribution Characteristics of Microbial Mineralization in Saturated Sand Centrifuge Shaking Table Test

Calcium carbonate induced by microorganisms can quickly fill and cement sand particles, thereby effectively reducing the potential for the liquefaction of sand. This process could represent a new green approach to the liquefaction treatment of saturated sand and has good prospects for application. However, owing to the diversity of microbial activities and the heterogenous spatiotemporal distribution of bacterial nutrient seepage in sandy soil foundations, the resultant complex distribution of calcium carbonate deposition in a sandy soil foundation can lead to differences in solidification strength and improvement effect. To understand the influence of earthquake action on the liquefaction resistance of saturated sand treated by microorganisms, and to evaluate the effect of microbial technology on sand liquefaction prevention under dynamic load, this study simulated the dynamic stress conditions of saturated sand under shear waves, using the world′s first centrifuge shaking table (R500B), which realizes horizontal and vertical two-way vibration. On the basis of spatial heterogeneity of microbial mineralization after centrifuge shaking table tests, the effect of microbial strengthening on liquefied sand was analyzed, and the spatial distribution of calcium carbonate mineralization was examined. The results showed that the distribution of microorganisms in the solidified soil exhibited obvious spatial heterogeneity with a significant edge effect. Although microbial mineralization effectively improved the liquefaction resistance of saturated sand, a sudden change in the process of calcium carbonate deposition altered the cementation of the sand with depth. Moreover, the curing strength had obvious complexity and uncertainty that directly affected the shear stiffness of the soil under dynamic load, and this constitutes one of the reasons for the degradation of shear stiffness of sand during liquefaction. The derived conclusions could be used as a reference for engineering applications of microbial treatment of a liquefiable sandy soil foundation.
Manajemen Internalisasi Nilai Karakter Anak Usia Dini di Lingkungan Keluarga

Penelitian ini bertujuan untuk mengetahui menajemen internalisasi nilai pada anak usia dini melalui pendidikan yang dilakukan dalam lingkungan keluarga. Sebagaimana kita ketahui bahwa, manajemen adalah suatu bidang ilmu yang dapat diterapkan di berbagai aspek kehidupan. Dalam hal ini penulis mencoba mengaplikasikannya pada bagaimana sebuah keluarga memenej internalisasi nilai-nilai karakter pada anak usia dini. Metode penelitian ini merupakan metode kualitatif melalui studi kepustakaan (library research). Data-data diperoleh dari berbagai litelatur baik buku, jurnal tabloid dan lain sebagainya kemudian diolah dan disajikan dalam bentuk narasi. Hasil penelitian menjelaskan bahwa manajemen internaliasi nilai karakter pada hakikatnya dapat dilakukan di keluarga melalui serangkaian proses Planing (perencanaan) seperti merencanakan visi, misi, strategi, serta konten penanaman nilai; organizing (pengorganisasian) baik yang berhubungan dengan waktu, sarana dan prasarana, penanggung jawab, actuating (pengaktualisasikan) yang meliputi pembiasaan, keteladanan dan penciptaan budaya keluarga, serta controlling (pengendalian) dengan melakukan pengendalian dalam keluarga.
4-OI Protects MIN6 Cells from Oxidative Stress Injury by Reducing LDHA-Mediated ROS Generation

Pancreatic beta cells are highly susceptible to oxidative stress, which plays a crucial role in diabetes outcomes. Progress has been slow to identify molecules that could be utilized to enhance cell survival and function under oxidative stress. Itaconate, a byproduct of the tricarboxylic acid cycle, has both anti-inflammatory and antioxidant properties. The effects of itaconate on beta cells under oxidative stress are relatively unknown. We explored the effects of 4-octyl itaconate—a cell-permeable derivative of itaconate—on MIN6 (a beta cell model) under oxidative stress conditions caused by hypoxia, along with its mechanism of action. Treatment with 4-OI reversed hypoxia-induced cell death, reduced ROS production, and inhibited cell death pathway activation and inflammatory cytokine secretion in MIN6 cells. The 4-OI treatment also suppressed lactate dehydrogenase A (LDHA)activity, which increases under hypoxia. Treatment of cells with the ROS scavenger NAC and LDHA-specific inhibitor FX-11 reproduced the beneficial effects of 4-OI on MIN6 cell viability under oxidative stress conditions, confirming its role in regulating ROS production. Conversely, overexpression of LDHA reduced the beneficial effects exerted by 4-OI on cells. Our findings provide a strong rationale for using 4-OI to prevent the death of MIN6 cells under oxidative stress.
A spatially explicit risk assessment of salamander populations to Batrachochytrium salamandrivorans in the United States

Amphibian populations are threatened globally by anthropogenic change and Batrachochytrium dendrobatidis (Bd), a fungal pathogen causing chytridiomycosis disease to varying degrees of severity. A closely related new fungal pathogen, Batrachochytrium salamandrivorans (Bsal), has recently left its supposed native range in Asia and decimated some salamander populations in Europe. Despite being noticed initially for causing chytridiomycosis‐related population declines in salamanders, Bsal can also infect anurans and cause non‐lethal chytridiomycosis or asymptomatic infections in salamanders. Bsal has not yet been detected in the United States, but given the United States has the highest salamander biodiversity on Earth, predictive assessments of salamander risk to Bsal infection will enable proactive allocation of research and conservation efforts into disease prevention and mitigation.
Pathophysiology and Therapy of Associated Features of Migraine

Migraine is a complex and debilitating disorder that is broadly recognised by its characteristic headache. However, given the wide array of clinical presentations in migraineurs, the headache might not represent the main troublesome symptom and it can even go unnoticed. Understanding migraines exclusively as a pain process is simplistic and certainly hinders management. We describe the mechanisms behind some of the most disabling associated symptoms of migraine, including the relationship between the central and peripheral processes that take part in nausea, osmophobia, phonophobia, vertigo and allodynia. The rationale for the efficacy of the current therapeutic arsenal is also depicted in this article. The associated symptoms to migraine, apart from the painful component, are frequent, under-recognised and can be more deleterious than the headache itself. The clinical anamnesis of a headache patient should enquire about the associated symptoms, and treatment should be considered and individualised. Acknowledging the associated symptoms as a fundamental part of migraine has permitted a deeper and more coherent comprehension of the pathophysiology of migraine.