Miracle-dz/UniFAR-FTUs huggingface dataset:
An investigation into effective methods for teaching social sustainability within product design in British and Irish Universities

Consideration of sustainability in product and industrial design courses is becoming more common and relevant within higher education in the UK. However little is known about how widespread the teaching is and what is actually understood as sustainable design with discrepancies in the definitions used in different institutions. Literature highlights that many universities now engage with the tangible environmental aspects of sustainable design, whilst the intangible social aspects are left unaddressed. This thesis explores methods for encouraging and enabling students to address the social aspects within sustainable product design (SPD) education. The first research stage presents the results of a nationwide survey, which investigated how widely SPD is taught, which social aspects are addressed, how SPD is taught and assessed and the attitudes and awareness of it amongst academics. The second research stage presents further research into best practice in SPD through detailed interviews with leading academics in the field. A third research stage built upon the findings from both these studies, and sought to address a perceived weakness in SPD education; the lack of understanding and consideration of the social aspects in sustainable product design in teaching and project outcomes. Three Rethinking Design workshops were developed and tested at five universities in the UK and Ireland. These workshops were designed to introduce students to the wider social aspects of SPD, through the use of audio visual group based workshops. The design of the workshops enabled a learning environment where a deep understanding of the social aspects of Sustainable Product Design could be developed through; group work, discussion and critical reflection, which led to students exploring design thinking responses, suggesting that deep learning, had occurred.
Reformasi Pelayanan Publik : teori, kebijakan, dan implementasi

Pada dasarnya setiap manusia membutuhkan pelayanan bahkan tidak dapat dipisahkan dengan kehidupan manusia itu sendiri seperti seorang bayi yang selalu menginginkan pelayanan dari seorang ibu. Dalam kehidupan bernegara, setiap warga negara juga membutuhkan pelayanan dari pemerintah atau birokrat sebagai pengendali kekuasaan yang dinamakan pelayanan publik (publik services). Dengan kebijakan-kebijakan yang diambil dan ditelorkan oleh pemerintah mereka berharap semua keinginan dalam segala segi terpenuhi dan terpuaskan. Pemerintah selalu melayani keinginan warga negaranya, bukan sebaliknya warga negaralah yang melayani pemerintah selama roda pemerintahan berjalan, Namun, selama ini yang mereka rasakan bahwa tuntutan akan pelayanan publik yang berkualitas jauh dari harapan, malahan pelayanan itu penuh dengan birokrasi yang berbelit-belit,lamban,mahal,dan melelahkan. Oleh karena itu, Perlu Perubahan kebijakan yang mendasar dalam pelayanan publik yang merupakan perubahan paradigma (paradigma sift), yaitu bagaimana para pelaku kebijakan melihat tantangan dan bagaimana persoalan. Cara pandang terhadap persoalan dan pemecahanya akan memposisikan pemerintah secara berbeda, sehingga perananya dan jenis kebijakan yang dihasilkan juga berbeda. Buku ini menguraikan dan mengulas dengan detail,scerdas,dan berwawasan keilmuwan yang tinggi serta gaya bahasa yang menarik mengenai reformasi pelayanan publik serta teori,kebijakan yang dihasilkan serta implementasinya dari birokrat dan birokrasi dari dulu sampai sekarang.
The Therapeutic Potential of Adipose Tissue-Derived Mesenchymal Stem Cells to Enhance Radiotherapy Effects on Hepatocellular Carcinoma

Several studies have investigated strategies to improve the clinical efficacy of radiotherapy (RT) against hepatocellular carcinoma (HCC), yet the prognosis remains poor. Human adipose tissue-derived mesenchymal stem cells (AT-MSCs), easily accessible and abundant in quantity, have represented as an attractive therapeutic tool for the stem cell-based treatment for cancer diseases. Through direct co-culture and indirect separate culture experiments, we showed that AT-MSCs could enhance inhibitory effect of RT on reducing HCC cell growth, migration and invasion in both in vitro and in vivo experiments. RNA-sequencing analysis revealed a noticeable interferon-induced transmembrane 1 (IFITM1)-induced tumor gene signature. Gain and loss of mechanistic studies indicated that mechanism was attributed to downregulated expression of signal transducer and activator of transcription 3 (STAT3) and matrix metallopeptidases (MMPs) and upregulated expression of P53 and caspases. Collectively, our findings suggest that AT-MSCs might enhance the therapeutic effects of RT on HCC, providing a rationale for AT-MSCs and RT combination therapy as a new remedy for HCC.
An Empirical Study on the Intention to Reuse Computational Science and Engineering Platforms: A Case Study of EDISON

The computational science and engineering field, which combines basic science and computing technology, has emerged as a third scientific methodology, following theories and experiments. This study aimed to identify factors and relationships that affect the continued use of the computational science and engineering (CSE) platform for its successful operation, utilization, and diffusion. To that end, the quality factors of the platform were derived by combining the information system success model and the technology acceptance model. These factors affected user satisfaction and intention to reuse through users’ perceived usefulness and perceived ease of use of the platform. An empirical analysis was conducted through a questionnaire survey of 373 users of the EDISON platform, a representative CSE platform in Korea. The results revealed that all quality factors have a positive influence on perceived usefulness and perceived ease of use. Specifically, information quality has a significant influence on perceived ease of use, and system quality has a significant influence on perceived usefulness. Perceived ease of use has a greater impact on user satisfaction than perceived usefulness, and satisfaction affects intention to reuse. The results can contribute to the development of CSE platforms and the development strategy to expand the number of users.
Real world effectiveness of benralizumab on respiratory function and asthma control

Background Biological drugs have been recognized as a breakthrough in the treatment of severe refractory asthma. This retrospective real-life observational study aims to evaluate the effect of add-on benralizumab on lung function, exacerbation rate, oral corticosteroids (OCS) reduction and asthma control questionnaire (ACQ) score after 52-weeks. Methods In this observational study, a cohort of 18 patients with severe eosinophilic asthma (SEA) according to the ERS / ATS and GINA 2020 classifications, with reference to the Pulmonology Unit of the Azienda USL - IRCCS, Reggio Emilia, Italy, were enrolled from 1 September 2019 to 31 August 2020. For each patient, the following data were collected: demographic data (age, sex, age of onset of asthma, history of smoking and atopy); comorbidity; clinical data (lung function, exacerbations, emergency room visits and hospitalizations); asthma control questionnaire (ACQ); biomarkers (blood eosinophil count and total serum IgE); asthma control drugs as high-dose inhaled corticosteroids / long-acting beta-adrenoceptor agonists (ICS / LABA), long-acting muscarinic antagonists (LAMA), leukotriene receptor antagonists (LTRA), theophylline, OCS. The benralizumab 30 mg treatment schedule was based on the currently recommended dosing regimen. Results After end-of-treatment (EOT), a complete weaning of all patients from OCS was confirmed. After 26 weeks, the number of exacerbations decreased from 2.90 to 0.05 (p<0.0001), hospitalizations and ACQ score decreased from 3.37 to 0.97 (p<0.0001). At EOT, the number of exacerbations was unchanged, while no hospitalizations had occurred. Overall, lung function markedly improved over the study period. After 52 weeks, the increase in FEV1 from baseline was 26,8% (p=0.0002). The subset of patients with nasal polyposis (NP) had an increase of nearly 50% (1008 ml) and patients with blood eosinophils count (BEC) greater than 500 cells / μl showed an increase of 68% (1081 ml) in FEV1 at EOT. Conclusions The notable improvement in respiratory function is a significant result in this study and it is much higher than what has emerged to date. This result, together with the OCS sparing effect and the excellent clinical control of asthma, makes benralizumab a reliable and safe therapeutic option for SEA.
Model predictive control of an exothermic batch reactor using near infrared (NIR) spectroscopic measurements as feedback

Batch and semi-batch processes provide needed flexibility for multi-product plants, especially when products change frequently and production quantities are small. However, challenges occur when trying to implement reliable control systems in batch processes due to some unavoidable inherent characteristics such as the presence of time-varying and nonlinear batch process dynamics and a host of unmeasured disturbances. The most typical control strategy employed in batch process operations does not use utilise online measurements of variables directly related to the product quality and as such is bound to produce off specification products even when the specified control objective has been met. Work done in this thesis is concerned with the design of a supervisory control scheme that takes into consideration the online status of the quality variable of interest from the beginning to the end of the batch process.A novel control methodology is proposed which combines the speed and flexibility of Near-Infrared (NIR) spectroscopic measurements as quality feedback variables within a multiple model predictive control (MPC) framework. In particular the multivariate NIR spectral data is pre-processed for feedback using a statistical model based on Independent Component Analysis (ICA). The proposed controller is tested on a benchmark simulated batch reactor using several case studies and is demonstrated to bring significant improvement in control performance when contrasted with other inferential and direct quality controllers.
Critical reappraisal of neoadjuvant concurrent chemoradiotherapy for treatment of locally advanced colon cancer

Background Locally advanced colon cancer (LACC) is associated with surgical challenges during R0 resection, increased postoperative complications, and unfavorable treatment outcomes. Neoadjuvant concurrent chemoradiotherapy followed by surgical resection is an effective treatment strategy that can increase the complete surgical resection rate and improve the patient survival rate. This study investigated the efficacy and toxicity of concurrent chemoradiotherapy in patients with LACC as well as the prognosis and long-term clinical outcomes of these patients. Materials From January 2012 to July 2020, we retrospectively reviewed the real-world data of 75 patients with LACC who received neoadjuvant concurrent chemoradiotherapy. The chemotherapy regimen consisted of folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX). The following data were obtained from medical records: patients’ characteristics, pathologic results, toxicity, and long-term oncologic outcome. Results Of the 75 patients, 13 (17.3%) had pathologic complete responses. Hematologic adverse effects were the most common (grade 1 anemia: 80.0% and leukopenia: 82.7%). Conversely, grade 2 or 3 adverse effects were relatively uncommon (<10%). Pathologic N downstaging, ypT0, and pathologic complete responses were significant prognostic factors for patient survival. Multivariate analysis revealed that pathologic N downstaging was an independent predictor of patients’ overall survival (P = 0.019). The estimated 5-year overall and disease-free survival rates were 68.6% and 50.6%, and the medians of overall and disease-free survival periods were 72.3 and 58.7 months, respectively. Moreover, patients with pathologic complete responses had improved overall survival (P = 0.039) and an improved local recurrence control rate (P = 0.042) but an unfavorable distant metastasis control rate (P = 0.666) in the long-term follow-up. Conclusion The long-term oncologic outcome of patients with LACC following concurrent chemoradiotherapy is acceptable, and the adverse effects seem to be tolerable. Pathologic N downstaging was an independent prognostic factor for patients’ overall survival. However, a large prospective, randomized control study is required to confirm the current results.
Phenotypic and genotypic study on antibiotic resistance and pathogenic factors of Staphylococcus aureus isolates from small ruminant mastitis milk in South of Italy (Sicily)

Staphyloccoccus aureus is the major cause of mastitis in small ruminants in the Mediterranean farms causing severe losses to dairy industry. Antibiotic treatment has been the most common approach to control these infections. Aim of this study was to investigate antimicrobial resistance (AMR), virulence factors and biofilm-related genes of 84 Sicilian strains of S. aureus isolated from sheep and goats milk during two different periods δT1 (2006-2009) and δT2 (2013-2015). Kirby Bauer method and Polymerase Chain Reaction (PCR) were utilized to monitor AMR and related genes (mecA, tetK, tetM, ermA, ermC). Moreover, toxin genes (tsst-1, sea-see, seg-sej, and sep) and biofilm genes (bap, ica, sasC) were studied. Twenty-six isolates (30.9%) showed multidrug resistance. The two groups showed similar results with exception for higher values of resistance for tilmicosin and lower for sulfamethoxazole and vancomycin of the second group. MecA gene was detected in one isolate. Tetracycline resistance was higher than 20%, with an increase in δT2 group. Toxin genes were found in 5 isolates (5.9%), belonging of δT2 group, while 57 of isolates (67.8%) showed biofilm related genes. The high presence of multi-resistant isolates suggests the need of more responsible use of antibiotic therapy for the control of these infections.
Developing and Using Models

Constructing Explanations and Designing Solutions Constructing explanations and designing solutions in 6– 8 builds on K–5 experiences and progresses to include constructing explanations and designing solutions supported by multiple sources of evidence consistent with scientific ideas, principles, and theories. Construct a scientific explanation based on valid and reliable evidence obtained from sources (including the students’ own experiments) and the assumption that theories and laws that describe the natural world operate today as they did in the past and will continue to do so in the future. (MS-ESS1-4) Crosscutting Concepts
A study of student engagement and the factors that contribute to students' use of blended learning technologies

Blended learning is an instructional method that blends both face-to-face and online learning. Oliver and Trigwell (2005) stated that while the use of blended learning has expanded greatly, it is not well understood in higher education. The purpose of this descriptive quantitative study at a Midwest university was to determine how student engagement factors predict the use of blended learning technologies in a blended learning program. The primary research instruments used were: The National Survey of Student Engagement and a technologies use survey based on the Unified Theory of the Acceptance and Use of Technology model. It was determined in this study that student engagement was a significant predictor in the use of blended learning technologies (F=6.14, p<.05). The level of academic challenge was the one student engagement factor out of four factors in the NSSE survey that significantly predicted students’ use of blended learning software (eCollege) at the university studied (F = 6.20, p=.0134), p< . 05). The findings in this study may support the development of future blended learning pedagogies, instructional design, and teaching methods. This study may also be beneficial to college and university leaders considering blended learning in improving student engagement, learning, retention, and financial results.
Network Representation Learning-Based Drug Mechanism Discovery and Anti-Inflammatory Response Against COVID-19

Recent studies have been demonstrated that the excessive inflammatory response is an important factor of death in COVID-19 patients. In this study, we proposed a network representation learning-based methodology, termed AIdrug2cov, to discover drug mechanism and anti-inflammatory response for patients with COVID-19. This work explores the multi-hub characteristic of a heterogeneous drug network integrating 8 unique networks. Inspired by the multi-hub characteristic, we design three billion special meta paths to train a deep representation model for learning low-dimensional vectors that integrate long-range structure dependency and complex semantic relation among network nodes. Using the representation vectors, AIdrug2cov identifies 40 potential targets and 22 high-confidence drugs that bind to tumor necrosis factor(TNF)-α or interleukin(IL)-6 to prevent excessive inflammatory responses in COVID-19 patients. Finally, we analyze mechanisms of action based on PubMed publications and ongoing clinical trials, and explore the possible binding modes between the new predicted drugs and targets via docking program. In addition, the results in 5 pharmacological application suggested that AIdrug2cov significantly outperforms 5 other state-of-the-art network representation approaches, future demonstrating the availability of AIdrug2cov in drug development field. In summary, AIdrug2cov is practically useful for accelerating COVID-19 therapeutic development. The source code and data can be downloaded from https://github.com/pengsl-lab/AIdrug2cov.git.
The Acceptance of Using Information Technology for Disaster Risk Management: A Systematic Review

The numbers of natural disaster events are continuously affecting human and the world economics. For coping with disaster, several sectors try to develop the frameworks, systems, technologies and so on. However, there are little researches focusing on the usage behavior of Information Technology (IT) for disaster risk management (DRM). Therefore, this study investigates the affecting factors on the intention to use IT for mitigating disaster’s impacts. This study conducted a systematic review with the academic researches during 2011-2018. Two important factors from the Technology Acceptance Model (TAM) and others are used in describing individual behavior. In order to investigate the potential factors, the technology platforms are divided into nine types. According to the findings, computer software such as GIS applications are frequently used for simulation and spatial data analysis. Social media is preferred among the first choices during disaster events in order to communicate about situations and damages. Finally, we found five major potential factors which are Perceived Usefulness (PU), Perceived Ease of Use (PEOU), information accessibility, social influence, and disaster knowledge. Among them, the most essential one of using IT for disaster management is PU, while PEOU and information accessibility are more important in the web platforms.
The Emergence of a National eID Solution : an Actor-Network Perspective

This paper will focus on the emergence of the Swedish National Electronic Identification (eID) from an Actor-Network perspective. As being a significant part of the public sectors delivery of secure electronic services, this seemingly limited technical artifact has an interesting potential in either enabling or limiting the public sectors ambitions for better and more secure electronic services. This paper will show that the emergence can be perceived as successful, but not as a product of a long term and pre-defined strategy formulated by the government. It is rather a product of a positive and emergent synergy between the public and market sector, driven by a strong belief in its potential by the actors involved in the ongoing process. By applying a lens of actor-network theory on the emergence of the eID, we have gained useful insights into how and why different actors have affected the emergence, as well as each other. By the processes of inscribing, translating and framing, this study analyses how actors have acted and interacted during the emergence with the focus on the influence of central beliefs. We argue, that with a clear focus on the actors concerned, governments have a better opportunity to successfully plan and implement complex inter-organizational solutions for electronic identification. This paper presents one possible approach to gain a better understanding of these aspects.
Influencias climáticas, regionales y cantidad de cría en el comportamiento higiénico de Apis mellifera

1Departamento de Ciencias Económicas y Administrativas. Centro Universitario del Sur. Universidad de Guadalajara. México, C.P. 49000. 2Departamento de Producción Agrícola, Centro Universitario de la Costa Sur. Universidad de Guadalajara. México, C.P. 48900.3School of Environmental Sciences, University of Guelph, 50 Stone Road East, Guelph, N1G 2W1, Ontario, Canada. 4 Centro en Investigaciones en Abejas, Centro Universitario del Sur. Universidad de Guadalajara. México, C.P. 49000. *Responsible author: José María Tapia González, **Author for correspondence: José Carlos Tapia Rivera, Dirección postal: Centro Universitario del Sur Av. Enrique Arreola Silva No. 883, colonia centro C.P. 49000, Ciudad Guzmán, Jalisco, México. Tel: 3415752222 ext: 46087. joset@cusur.udg. mx, talit89@hotmail.com, francisca.contreras@academicos.udg. mx, joseoc@cusur.udg. mx, jose.tapia@cusur.udg. mx, eguzman@uoguelph.ca ABSTRACT The hygienic behavior of honeybees (Apis mellífera) is a mechanism highly influenced by genetic effects that confers resistance against diseases and parasites. The objective of this study was to determine whether climatic, regional and brood quantity influences are related to hygienic behavior in beehives in Jalisco state, Mexico. Freezing pupae with liquid nitrogen in two climatic zones (mountain and valley) evaluated 142 colonies. Colonies located in the municipalities of the low zone removed significantly more frozen brood than the colonies located in the municipalities of the higher zone (p <0.001), and these differences were significantly correlated with environmental temperature (r = 0.25, p <0.01) and altitude above sea level (r = 0.27, p <0.001). It was also found that in the warmer, lower altitude region, one third of the colonies were highly hygienic (> 80 %). This degree of cleanliness is acceptable for initiating selective breeding projects for highly hygienic bees to improve colony health, which would benefit the beekeeping industry.
AUTOMATED HIGHWAY SYSTEMS OVERVIEW AND EXPERIMENT RESULTS

The first Japanese AHS operational test using the actual expressway before practical use in the world has been carried out in September 1996. The purpose of the experiment was to examine existing technology to evaluate feasibility of AHS development and to integrate technology. With this study, it became clear that there is sufficient basic technology and feasibility to develop a practical system. In this paper, the authors provide an overview of the examination and results. Various technical approaches ranging from a test vehicle to infrastructure were included in this experiment. Results from the following experiments are reported: (1) experiment associated with vehicle control maneuvering corresponding to the roadway geographic alignment; (2) experiment on the impact of on-board devices by various external factors; and (3) experiment for integrated technology. For the covering abstract, see IRRD 490001.