Miracle-dz/UniFAR-FTUs huggingface dataset:
Flow cytometric analysis of megakaryocytes from patients with abnormal platelet counts

Megakaryocytes (MKs) from 40 patients with quantitative platelet disorders and 19 normal volunteers were analyzed by flow cytometry for size, fine cell internal structure and granularity, membrane expression of the glycoprotein (GP) IIb/IIIa complex, and for ploidy distribution. Analysis was performed on unfractionated minimally manipulated marrows obtained from routine bone marrow aspirates. MKs were labeled with a fluorescent lineage-specific monoclonal antibody to the GPIIb/IIIa complex followed by DNA staining with propidium iodide. Eight hundred to 3,000 MKs were analyzed in each sample. The modal ploidy distribution in normals was 16N, comprising about half of the megakaryocytic population, with 22.6% of the cells less than or equal to 8N and 22.0% greater than or equal to 32N. Twelve thrombocytopenic patients with decreased marrow MKs on biopsy (mean platelet count [MPC] 44,600/microliters) showed an increase in low ploidy cells with 53.2% less than or equal to 8N (P less than .01); cell size was reduced in three patients when compared to normal cells of identical ploidy (P less than .05). Eight thrombocytopenic patients with enhanced platelet destruction (with normal or increased MKs on biopsy and shortened platelet survival; MPC 41,400/microliters) showed an increased proportion of high ploidy cells greater than or equal to 32N to 39.2% (P less than .01). Increased cell size and granularity were found in four of these patients (P less than .05). Six patients with thrombocytopenia secondary to multiple mechanisms affecting both platelet production and destruction (MPC 66,700/microliters) showed no shift in ploidy. Four patients with primary thrombocytosis (two with thrombocythemia and two with polycythemia vera; MPC 822,500/microliters) showed a marked shift toward high ploidy cells with 42.3% greater than or equal to 32N and 7.6% greater than or equal to 64N cells (P less than .01). The shift was accompanied by a marked increase in cell size and granularity in the patients with thrombocythemia. Ten patients with thrombocytosis secondary to chronic blood loss, malignant or inflammatory disorders (MPC 714,000/microliters), showed variable distributions with four patients exhibiting a shift in ploidy to the right similar to that found in the patients with increased platelet destruction. Based upon the present data, flow cytometric ploidy distribution may be diagnostically useful in thrombocytopenic patients by discriminating between disorders of platelet production and destruction.
Intramuscular hemangioma of the subscapularis muscle presenting with isolated loss of external rotation of the shoulder

Intramuscular hemangioma located in the rotator cuff muscles is extremely rare and only few cases have been published. Isolated loss of external rotation of the shoulder with the arm resting at the side is a rare clinical finding in patients presenting with a shoulder problem. In response, we report a case of intramuscular hemangioma of the subscapularis muscle in a 21-year-old male, presented with right shoulder pain and isolated loss of external rotation of the shoulder, and treated with surgical excision.
New trends in the treatment of b-thalassemia

Thalassemia is the world's most common hereditary disease, and is a paradigm of monogenic genetic diseases. Because of increased population mobility, the disease is found today throughout the world, even in places far from the tropical areas in which it arose. Therapy of thalassemia has in the past been confined to transfusion and chelation. Recently, novel modes of therapy have been developed for thalassemia, based on the pathophysiology and molecular pathology of the disease, both of which have been
Extracorporeal Membrane Oxygenation (ecmo) In Adults In The United States From 2006-2011

Objective: Recent studies have shown the benefits of extracorporeal membrane oxygenation (ECMO) in supporting adults with severe respiratory or cardiac failure refractory to conventional treatments. The purpose of this investigation was to analyze the utilization of ECMO in adults to identify recent trends within the United States. Methods: In a serial cross-sectional study, the utilization rate of ECMO in adults in the United States from 2006 to 2011, as well as the survival rates and costs of hospitalization were analyzed using the Nationwide Inpatient Sample (NIS) from the Healthcare Cost and Utilization Project (HCUP). The survival rates were further analyzed by grouping the hospitals by size, type, or volume of adult ECMO cases. Results: The rate of ECMO cases per million adult discharges increased 433% from 11.4 (95% CI, 6.1-16.8) in 2006 to 60.9 (95% CI, 28.1-93.7) in 2011 (p for trend = 0.001). Throughout this six-year period, there were no statistically significant changes in the survival rates (p for trend = 0.14), costs per day (p for trend = 0.07), or total costs per patient (p for trend = 0.87). Hospitals that were small, nonteaching, or had few adult ECMO cases were more likely to transfer their patients to other acute care hospitals. Conclusion: From 2006 to 2011, there was a huge increase in the utilization of ECMO in adults with no significant changes in survival rates or hospitalization costs. ECMO as a therapeutic modality should be given consideration in critically ill patients with reversible cardio-respiratory collapse.
Undetectable Troponin I at Presentation Using a Contemporary Assay does not Rule Out Myocardial Infarction

Objective Chest pain is a common reason for presentation to emergency departments (ED). Recent evidence suggests that an undetectable troponin level at ED presentation can rule out the presence of myocardial infarction (MI). The aim of this study was to externally validate that finding using a troponin I (TnI) assay. Methods Unplanned sub-study of a prospective observational cohort study of patients presenting to ED with chest pain without electrocardiogram evidence of ischaemia who underwent a ‘rule out’ acute coronary syndrome process. Clinical, investigational and outcome data were collected. Primary outcome of interest was diagnostic accuracy for type I MI at index visit. Results 685 patients were studied; median age 62, 60% male. Two hundred and seventeen had an undetectable TnI at ED presentation. There were two non-ST elevation myocardial infarctions in the group (2/217, 0.9%, 95% CI 0.16-3.6%). Sensitivity of undetectable TnI for ruling out type I MI was 98. 2% (99% CI 92.9-99.7%) with negative predictive value of 99.1% (96.4-99.8%). Conclusion Approximately 1% of patients with an undetectable TnI at ED presentation were diagnosed with a type I MI. An undetectable initial TnI using a contemporary sensitive TnI assay does not safely exclude MI in an ED chest pain cohort. (Hong Kong j.emerg.med. 2014;21:31-36)
Storage of Platelet Concentrates at 22°C

A technique has been proposed which allows easy preparation of platelet concentrates within a closed, sterile system and maximal utilization of other blood components. Lifespan studies have been performed to demonstrate the viability of platelets prepared in this manner. Such concentrates can be stored for as long as three days with adequate maintenance of viability for tranfusion purposes if certain technical requirements are met. Important among these are attention to concentrate volume and pH; agitation of the concentrate is helpful for maintenance of viability. Twelve studies in thrombocytopenic recipients suggest that stored concentrates will be safe and effective in transfusion practice.
PREVALENCE DU VIH ET DE L'ANTIGENE HBS CHEZ LES DONNEURS DU SANG. RISQUE RESIDUEL DE CONTAMINATION CHEZ LES RECEVEURS DE SANG A KINSHASA-EST,REPUBLIQUE DEMOCRATIQUE DU CONGO

’ i n fection a VIH est aujourd’hui une pandemie. L’ a n t i g e n ede surface (Ag HBs) du virus de l’hepat i t eB (VHB) estun marqueur de port age ch ronique concernant trois cent mil-lions d’individus dans le monde (1). Le port age ch ro n i q u ed’Ag HBs est tres frequent chez les port e u rs du VIH (2,3). Le depistage d’anticorps anti-VIH1 et de l’Ag HBsavant toute transfusion n’est pas systematique dans les citesp e ri p h e riques de la ville de Kinshasa,R e p u bl i q u eDemocratique du Congo. Des transfusions sanguines nonsecurisees sont donc quotidiennement administrees auxe n fants et aux adultes pour traiter une anemie ou une hemor-ragie. Bien que la serologie VIH1 et le portage de l’Ag HBsaient deja fait l’objet de nombreuses publ i c ations enA f rique centrale (4,5 ) ,l’interet de la presente etude tient ausite geographique de la ville de Kinshasa,grande metro p o l ed’Afrique centrale. Les objectifs du present travail sont de donner unpoint recent sur la sero p r e valence et les cara c t e ristiques socio-demographiques de l’infection a VIH et du portage de l’AgHBs dans la population des donneurs de sang a Kinshasa-Est;de determiner la frequence de l’association Ag HBs-VIH1chez les donneurs de sang; et d’evaluer le risque residuel pourles receveurs.
Comparative Study on the Trans-Province Transfer of the Multiple Trauma Patients after Sichuan Earthquake

Background: Trans-province transfer of the patients has been successfully carried out and has greatly relieved the burden of the hospitals in Sichuan Province after Sichuan earthquake. The aim of the study was to retrospectively analyze the efficacy and feasibility of the trans-province transfer of the multiple trauma patients after Sichuan earthquake. Methods: A retrospective and descriptive analysis was conducted based on the medical records of the multiple trauma patients (ISS ≥ 16) transferred to the Grade 3A hospitals outside Sichuan province. The patients were divided into two groups based on the distance to Sichuan province, i.e., Group A (the seismic patients transferred to Chongqing) and Group B (the seismic patients transferred to the other provinces/ municipalities). A comparison was done in aspects of distance of transfer, time from injury to transfer, vital signs, the infection rates (at transfer and on discharge), injury severity and prognostic indices (cure rate, disability rate and mortality). Results: The distance between Chengdu and the other places was at a wide range of 313 - 1653 km, whereas the time from injury to transfer showed no statistical difference between groups (P > 0.05). There were no significant differences between both groups with respects to patient demographics, injury mechanism, time from injury to transfer, vital signs, infection rate and injury severity. The prognostic indices showed no significant difference, except for FIM scores (P < 0.05). Conclusions: The results of the study indicate that the different distance of the transfer of the multiple trauma patients does not aggravate the severity or deteriorate the prognosis, which proves that the medical supportive transfer system is acceptable, effective and worthy of further implementation in China, which may be ascribed to the advanced transportation system and high level of therapeutic capacity of the hospitals. In the meantime, attention should be paid to psychological intervention and functional rehabilitation during the treatment of the transferred seismic patients.
Growth performance and carcass characteristics of broiler chicken fed with probiotics

One hundred and sixty day old commercial broiler chicks were distributed at random into four groups of 20 chicks, each having 2 replicates, were fed probiotic Biospur in the ration at the rate of 0, 25, 50 and 75g per 100 kg upto 6 weeks of age. Body weight gain was significantly higher in the treated groups. Biospur supplementation at higher levels resulted in significantly higher dressing and edible meat yields. The percent kidney, spleen, plancreasand liver did not differ significantly among the various treatments. Cost benefit analysis revealed increasing monetary gain attributable to the higher supplementation levels of Biosper. It is concluded that the performance of broiler chicken was improved when fed with diets containing Biospur @ 75g/100 kg feed upto 6 weeks of age.
Influence of Dietary Supplementation of Phospholipids and Lysophospholipids on Performance of Broilers

An experiment was conducted on 144 day old commercial broilers for 42 days to compare the influence of dietary supplementation of phospholipids and lysophospholipids on their performance. Experimental birds, divided equally in four groups, were offered standard broiler mash supplemented with 0.05% phospholipids, 0.05% and 0.1% lysophospholipids in groups T1, T2 and T3, respectively while, group T0 was offered no supplement. At the end of six weeks, significantly higher body weights were recorded in groups T2 (1758.92 g) and T3 (1776.53 g) than other groups. The mean weekly feed conversion ratio was also better in groups T2 and T3. Nitrogen retention was the highest in group T3 (56%) followed by T2 (53.58%), T1 (51.45%) and lowest in control (44.41%) group. The serum total cholesterol level was lower in groups T2 and T3, while muscle cholesterol was lowest in group T2. Dressing percentage was higher in group T1 (63.17%) than in groups T0 (60.64%), T2 (61.18%) and T3 (61.64%). Percent net profit/kg body weight was higher in groups T2 and T3 than in other groups.
Comparative Study of RF Sputtered Ba2(BiNb)O6 and Ba2Bi1.4Nb0.6 O6 thin films and Effect of Fluorine Doping in Their Photoelectrochemical (PEC) Performances

Bismuth based ternary oxide photocatalysts are of considerable interest in photoelectrochemical water splitting. Yet these oxides are highly stable in different environment, their relative inertness limits the available synthesis routes to obtain desired stoichiometry on the final product. This report describes a method to prepare barium bismuth niobate (specifically, Ba2(BiNb)O6 and Ba2Bi1.4Nb0. 6 O6) target by sintering a mixture of individual oxides and successfully fabricate desired barium bismuth niobate thin film on TCO substrate. The surface morphology, physical, and chemical properties of thin film were systematically investigated. Compositional uniformity was obtained by sputtering in oxygen argon plasma environment and higher photocatalytic activities were observed after subsequent surface treatments. Sodium fluoride surface treatment further enhanced the photocurrent density and improved electrode stability against corrosion. This work further suggests a viable approach to improve the PEC performance of sputtered barium bismuth niobate by modulating their fundamental energy states.
The structural basis of equine neck pain

THE STRUCTURAL BASIS OF EQUINE NECK PAIN By Nicole Rombach To date there are large gaps in the knowledge about the phenomenon of neck pain in the horse. This dissertation, which consists of four studies, aims to elucidate neck pain in the horse based on the concepts of neuromotor control and dynamic stability associated with neck pain in people. The first study describes the anatomy and morphology of two perivertebral muscles, namely, m. multifidus cervicis and m. longus colli. Both muscles are closely associated with neuromotor control and dynamic stability in people with neck pain. Based on findings in dissection, their anatomy and morphology are similar to those in people. As such, both muscles may play a role in vertebral stability in the neck of the horse. The second study investigated the prevalence and severity of osseous degenerative lesions in the articular process articulations of the equine cervical and cranial thoracic spine. Based on grading of osseous lesions of the articular process articulationsin this anatomical region, osseous degeneration is most prevalent in the mid-cervical and cervicothoracic region, and more prevalent in older and larger horses. In the first part of the third study, a technique was developed for repeatability of measurement of the cross-sectional area of m. multifidus cervicis and m. longus colli in the equine cervical spine, using ultrasound imaging. In the second part of this study, intraand inter-operator repeatability was determined for measurement of the cross-sectional area of m. multifidus cervicis and m. longus colli in the equine cervical spine, using the ultrasound imaging technique that was developed in the first part of the study. Evaluation of the size of both muscles is of particular interest in programs of therapeutic rehabilitation, which aim to increase the size of perivertebral muscles to improve vertebral stability and reduce the recurrence of episodes of neck pain, particularly those associated with osseous degenerative changes in the cervical spine. Results from this study show that US is a repeatable technique for CSA measurement of m. multifidus cervicis and m. longus colli at specific levels of the equine cervical spine. The fourth study used behavioral responses from horses during a manual examination to develop an ethogram of specific behaviors that may be observed in manual examination of horses with neck pain. Distinct aversive behavioral responses from manual palpatory assessment and mobilization techniques in the cervical spine and cervicothoracic junction of horses were identified in some horses with neck pain. This study also investigated whether manual examination techniques could be applied in the equine cervical spine to identify horses with diagnosed neck pain as compared to control cases. In blinded examination, the manual therapy practitioner who carried out the evaluations was able to correctly place each horse into its respective category of neck pain versus control subject, according to responses from the manual examination techniques that were applied to the
Elastic and Fracture Properties of Single Walled Pentagraphene Nanotubes

Membranes of carbon allotropes comprised solely of densely packed pentagonal rings, known as pentagraphene, exhibit negative Poisson's ratio (auxetic behavior) and a bandgap of $3.2$ eV. In this work, we investigated the structural stability, mechanical and fracture properties of nanotubes formed by rolling up pentagraphene membranes, the so-called pentagraphene nanotubes (PGNTs). Single-walled PGNT of three distinct configurations: zigzag, $\alpha$-armchair, and $\beta$-armchair were studied combining first-principles calculations and reactive molecular dynamics simulations. Our results showed Young's modulus values of $680-800 GPa$, critical strain of $18-21\%$, and ultimate tensile stress of $85-110 GPa$. We also observed auxetic behavior. During stretching at room temperature, we observed a transition between $\beta$-armchair to $\alpha$-armchair PGNT close to the critical strain. With relation to fracture patterns, we observed that mechanical failure starts at bonds mostly aligned to the stretching direction and after tube radial collapse.
The mystery of photometric twins DES17X1boj and DES16E2bjy

We present an analysis of DES17X1boj and DES16E2bjy, two peculiar transients discovered by the Dark Energy Survey (DES). They exhibit nearly identical double-peaked light curves that reach very different maximum luminosities (Mr = −15.4 and −17.9, respectively). The light-curve evolution of these events is highly atypical and has not been reported before. The transients are found in different host environments: DES17X1boj was found near the nucleus of a spiral galaxy, while DES16E2bjy is located in the outskirts of a passive red galaxy. Early photometric data are well fitted with a blackbody and the resulting moderate photospheric expansion velocities (1800 km s−1 for DES17X1boj and 4800 km s−1 for DES16E2bjy) suggest an explosive or eruptive origin. Additionally, a feature identified as high-velocity Ca ii absorption ($v$ ≈ 9400 km s−1) in the near-peak spectrum of DES17X1boj may imply that it is a supernova. While similar light-curve evolution suggests a similar physical origin for these two transients, we are not able to identify or characterize the progenitors.
DEGREE AND TYPES OF DOMESTIC ABUSE IN THE ELDERLY REFERRING TO PARKS OF TEHRAN

Background Aging has always been concerned throughout history. The second half of the 20 th century has been referred as population graying due to increased number of elderly people. Of related familial and social outcomes is the upsurge of antisocial behaviors and violence. Domestic elder mistreatment or abuse as a major health problem is a type of familial violence with a significantly increasing incidence in the last 2 decades. Since there is no specific organization to be responsible for this problem in developing countries like Iran, no information or evidence is available and limited studies are only limited to developed countries. Purpose This descriptive study was conducted to determine the degree and types of domestic abuse in the elderly referring to parks of Tehran. Methods 400 elders 60 years and over including men and women from all parts of Tehran took part in the study. A questionnaire in 3 parts including demographics, types of abuse and open questions was used for data collection. The tool was validated by face and content methods and made reliable by internal consistency as well as test-retest methods. The questionnaire was completed by the researcher through interviewing the subjects. Results Findings showed that 28% of the elderly was between 70 and 74, 38.2% had secondary education, 65.1% was married and 32.9% lived with their spouses. 87.8% of them experienced at least 1 type of abuse, 12.2% no abuse and 24.9% all 4 types of abuse. 84.8% experienced emotional abuse; 68.3%, neglect; 40.1%, financial exploitation; and 35.2%, physical abuse. A positive correlation was found between age and abuse. In contrast, no relationship was found between abuse and sex, educational level, marital status, living condition as well as geographic area. Conclusion It can be concluded that domestic abuse is a widespread social problem which requires urgent, continuous and fundamental interventions. Clarification of the issue from different aspects, identification of predisposing and preventive factors and recognition of at-risk elderly are of high priorities in this regard. Keywords: Elderly, Domestic abuse, Parks.
Sharp quantitative stability of the planar Brunn–Minkowski inequality

We prove a sharp stability result for the Brunn-Minkowski inequality for $A,B\subset\mathbb{R}^2$. Assuming that the Brunn-Minkowski deficit $\delta=|A+B|^{\frac{1}{2}}/(|A|^\frac12+|B|^\frac12)-1$ is sufficiently small in terms of $t=|A|^{\frac{1}{2}}/(|A|^{\frac{1}{2}}+|B|^{\frac{1}{2}})$, there exist homothetic convex sets $K_A \supset A$ and $K_B\supset B$ such that $\frac{|K_A\setminus A|}{|A|}+\frac{|K_B\setminus B|}{|B|} \le C t^{-\frac{1}{2}}\delta^{\frac{1}{2}}$. The key ingredient is to show for every $\epsilon>0$, if $\delta$ is sufficiently small then $|co(A+B)\setminus (A+B)|\le (1+\epsilon)(|co(A)\setminus A|+|co(B)\setminus B|)$.
Physics approaches to the spatial distribution of immune cells in tumors

The goal of immunotherapy is to mobilize the immune system to kill cancer cells. Immunotherapy is more effective and, in general, the prognosis is better, when more immune cells infiltrate the tumor. We explore the question of whether the spatial distribution rather than just the density of immune cells in the tumor is important in forecasting whether cancer recurs. After reviewing previous work on this issue, we introduce a novel application of maximum entropy to quantify the spatial distribution of discrete point-like objects. We apply our approach to B and T cells in images of tumor tissue taken from triple negative breast cancer patients. We find that the immune cells are more spatially dispersed in good clinical outcome (no recurrence of cancer within at least 5 years of diagnosis) compared to poor clinical outcome (recurrence within 3 years of diagnosis). Our results highlight the importance of spatial distribution of immune cells within tumors with regard to clinical outcome, and raise new questions on their role in cancer recurrence.