Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation of Surfactant Protein-D (SP-D) Serum Levels with ARDS Severity and Mortality in Covid-19 Patients in Indonesia

Objective. The purpose of this research was to investigate the correlation between serum levels of surfactant protein-D (SP-D) with acute respiratory distress syndrome (ARDS) severity and mortality in COVID-19. Materials and Method. This was a prospective cohort research study that included 76 patients in the period from July to October 2020. SP-D serum levels were taken upon admission to the hospital, the diagnosis of ARDS and its grade were confirmed according to the WHO criteria, and then patients were observed for 28-day mortality. Results. The mean SP-D serum levels from 76 patients were 39.33 ng/ml (SD±31.884 ng/ml). The statistical analysis showed that there was a significant correlation between SP-D serum levels and the severity of ARDS upon admission to the hospital (P=0.04, Spearman’s rank correlation coefficient (rs)=0.26), but the correlation between serum levels of SP-D and mortality was not statistically significant (P=0.89; rs=-0.016). Conclusion. SP-D serum levels had a significant but weak correlation with ARDS severity, but were not significant for mortality.
How good is the agreement between clinical diagnoses and classification criteria fulfilment in axial spondyloarthritis? Results from the SPARTAKUS cohort

Objectives To study the agreement between clinical axial spondyloarthritis (axSpA) diagnoses and fulfilment of the Assessment of SpondyloArthritis international Society (ASAS) axSpA and modified New York (mNY) classification criteria, and to compare disease/health status between axSpA subtypes. Method Patients with prevalent, clinical axSpA attending a rheumatology clinic were enrolled in a cross-sectional study. Assessments included physical evaluation, laboratory testing, questionnaires, and appropriate imaging, allowing classification. Standard axSpA outcome measures were compared between patients fulfilling mNY/radiographic versus non-radiographic axSpA (r-axSpA/nr-axSpA) criteria. Results Of 239 consecutively included patients, 141 fulfilled ASAS r-axSpA and/or mNY criteria, while 57 fulfilled nr-axSpA criteria. The agreement between r-axSpA and mNY criteria fulfilment was 94%. The positive predictive value (PPV) of a clinical ankylosing spondylitis (AS) diagnosis for mNY criteria fulfilment was 71%; the PPV of an undifferentiated axSpA (u-axSpA) diagnosis for fulfilment of nr-axSpA criteria was 30% and 40% for mNY criteria. Patients with r-axSpA/AS were older, more often men, and had longer disease duration, more uveitis, and worse spinal mobility than nr-axSpA patients, who had more enthesitis and dactylitis. Conclusion We found an overall good concordance between clinical axSpA diagnoses and classification criteria fulfilment, with 83% fulfilling ASAS axSpA and/or mNY criteria. Regarding axSpA subtypes, the concordance was weaker, and although the ICD-10 code for AS correctly identified patients meeting mNY criteria in 71% of cases, one-third of mNY-positive patients lacked an AS diagnosis. Moreover, clinical u-axSpA diagnoses could not serve as a proxy to identify nr-axSpA, highlighting the importance of thorough classification in research on axSpA subtypes.
Clopidogrel Resistance Among Ischemic Stroke Patients and Its Risk Factors in Indonesia

Objective. Clopidogrel is a common antiplatelet used as secondary prevention of ischemic stroke, known to have better efficacy than aspirin, with a equivalent safety profile. However, clopidogrel resistance is not uncommon but has not been widely studied in Asia. This study will further assess clopidogrel resistance and its risk factors. Materials and Methods. A cross-sectional study was conducted at Rumah Sakit Universitas, Indonesia, and Rumah Sakit Cipto Mangunkusumo, Indonesia in 2020-2021. All patients had had at least one episode of ischemic stroke. Clopidogrel resistance was assessed using a VerifyNow assay. Results. 57 subjects were enrolled in this study. We found 15.8% of subjects were clopidogrel resistant. Gender was significantly associated with clopidogrel resistance, with males having 80% lower clopidogrel resistance (OR 0.2 (95% CI 0.022 – 0.638); P=0.006). Meanwhile, smoking was not associated with clopidogrel responsiveness (P=0.051). We found no association between haemoglobin, blood glucose, HbA1c, cholesterol, liver enzymes, serum urea concentration or creatinine levels and clopidogrel resistance. Conclusion. Clopidogrel remains an effective treatment to prevent recurrent ischemic stroke in Indonesia. Further studies are needed to assess gene polymorphism and clopidogrel resistance, which may explain the findings of this study.
Self-perceived affective, behavioral, and cognitive reactions associated with voice use in people with Parkinson’s disease: a pilot study

Abstract Purpose This study aimed to compare the affective, behavioral, and cognitive reactions related to vocal function in people with Parkinson’s disease (PWPD) and healthy controls using the Behavior Assessment Battery – Voice (BAB-Voice). The test’s internal consistency was also described. Methods 31 PWPD and 19 healthy controls were recruited from September 2020 to March 2021. Participants completed four BAB-Voice subtests: Speech Situation Checklist – Emotional Reaction (SSC-ER), the Speech Situation Checklist – Speech Disruption (SSC-SD), Behavior Checklist (BCL), and Communication Attitude Test for Adults (BigCAT), describing the experienced negative emotional reaction, voice disruptions, coping behaviors, and negative attitude regarding communication respectively. Subtest scores were calculated and analyzed. Results The scores of the PWPD were significantly different from those of the controls (Pillai’s Trace = 0.344, F[4] = 5.508, p = .001, ηp 2 = .344): PWPD showed more negative emotions and voice problems, more coping behaviors, and more negative speech-related attitude compared to healthy controls. All subtests showed excellent internal consistency. Conclusions The BAB-Voice proved a tool with a good internal consistency that measured different psychosocial reactions in PWPD versus controls. PWPD exhibited significantly more negative emotions and voice problems in specific speech situations, more coping behaviors, and a more negative speech-related attitude. The specificity of information obtained from the BAB-Voice may aid in improving the treatment planning of voice disorders in PWPD.
Bronchial thermoplasty: State of the art

Since the publication of a sham‐controlled, randomized trial (AIR2) and subsequent marketing approval by the US Food and Drug Administration, we have significantly advanced our understanding of bronchial thermoplasty (BT)'s scientific basis, long‐term safety, clinical efficacy and cost‐effectiveness. In particular, the last 2 years have witnessed multiple research publications on several of these counts. In this review, we critically appraise our evolving understanding of BT's biologic underpinnings and clinical impact, offer an evidence‐based patient workflow guide for the busy pulmonologist and highlight both current challenges as well as potential solutions for the researcher and the clinician.
A constructivist approach to teach neuroanatomy lab: Students’ perceptions of an active learning environment

Background A recent trend in medical education is developing a more dynamic and integrated curriculum. Team-based learning (TBL) increases students’ engagement and the active construction of anatomical knowledge. This initial study aimed to empirically observe medical students’ perceptions of their achievement of learning outcomes and the construction of their neuroanatomy knowledge, critical thinking, and problem-solving using an interactive whiteboard (IWB) as a teaching strategy. Methods An independent neuroanatomy lab survey collected students’ perceptions and comments about their learning experiences using the IWB on a questionnaire using a 5-point Likert scale. Results Student participants felt that using the IWB has facilitated their learning experience. 94.2% of student participants endorsed feelings that new technology has helped them achieve their learning outcomes, helped them integrate both their basic science and clinical science/skills knowledge (90.4%), enhanced their problem-solving skills (92.3%), facilitated their interaction with the neuroanatomy faculty (96.2%) and increase their critical thinking (88.4%). Conclusion Collecting such empirical data about students’ perceptions and their learning environment should help neurosciences faculty in medical schools better outline their activities to faculty at other medical institutions. Applying these methods may enhance the learning process, save time during neuroanatomy lab, and it could also help overcome the shortage of qualified neuroanatomy educators.
Employee-organization Congruence and Job Performance: Development of a Conceptual Model

Research on Employee-Organization Congruence (EOC) has focused on the effect of EOC on individual performances. However EOC and job performance relationship and its contextual validity have not been explored in Sri Lankan apparel sector. This paper has explored the specific factors specially related to the Sri Lankan apparel sector work environment. Among these variables EOC considered as independent variable, job performance as a dependent variable. The conceptual model of this study investigates job related attitudes, namely job satisfaction and organizational commitment as two potential mediating factors for the EOC and job performance relationship. Further organizational climate has been cited as possible moderating factor on EOC and job performance relationship. This paper makes a significant contribution to the body of knowledge with the proposed conceptual framework so that it can be used as a basis for the future research in this context.
Investigation of fungal contamination in medicinal and edible Lycii Fructus through DNA metabarcoding

Lycii Fructus (LF) is considered as a ‘superfood’ due to its health benefits and delicious tastes, which has gained popularity worldwide. However, LF is also a proper host for fungal growth due to its abundant nutrients. Fungal contamination seriously affects the quality and safety of LF and poses threats to consumer health.
The Relationship between Boredom Proneness, Attachment Styles and Compulsive Sexual Behavior

Abstract Affect regulation is associated with compulsive sexual behavior (CSB) despite ongoing debate about its inclusion in diagnostic criteria. Previous studies on two specific affect regulation constructs – boredom proneness and attachment styles – suggest that affect regulation is associated with CSB. We tested a moderation model of the effects of attachment anxiety and attachment avoidance on the relationship between boredom proneness and CSB. Results indicate that the relationship between boredom proneness and CSB is stronger at higher levels of attachment anxiety, with no interaction between boredom proneness and attachment avoidance. Overall findings support the importance of affect regulation in conceptualizing and treating CSB.
A scoping review of clusters of multiple long-term conditions in people with intellectual disabilities and factors impacting on outcomes for this patient group

People with intellectual disabilities (ID) are vulnerable to multiple long-term conditions (MLTC). However, in the UK, there are no individual strategies tailored for them. This study synthesised evidence on prevalence of MLTC in people with ID alongside risk factors, outcomes and preventative strategies. The scoping review used the tool Abstrackr to search retrieved articles from three bibliographic databases. Of 933 articles initially screened and further identified, 20 papers met our inclusion criteria. Our findings revealed significant data on prevalence of MLTC in people with ID across the studies, but very limited data on clusters or patterns of co-occurrence in this population. The majority of papers explored risk factors and strategies for prevention of MLTC, but far fewer compared outcomes by MLTC. The identified gaps in the literature indicate the need for further research to identify clusters of MLTC and tailored prevention strategies to reduce poor outcomes in this population.
Clinical Implications of Focal Mineral Deposition in the Globus Pallidus on CT and Quantitative Susceptibility Mapping of MRI

Objective To assess focal mineral deposition in the globus pallidus (GP) by CT and quantitative susceptibility mapping (QSM) of MRI scans and evaluate its clinical significance, particularly cerebrovascular degeneration. Materials and Methods This study included 105 patients (66.1 ± 13.7 years; 40 male and 65 female) who underwent both CT and MRI with available QSM data between January 2017 and December 2019. The presence of focal mineral deposition in the GP on QSM (GPQSM) and CT (GPCT) was assessed visually using a three-point scale. Cerebrovascular risk factors and small vessel disease (SVD) imaging markers were also assessed. The clinical and radiological findings were compared between the different grades of GPQSM and GPCT. The relationship between GP grades and cerebrovascular risk factors and SVD imaging markers was assessed using univariable and multivariable linear regression analyses. Results GPCT and GPQSM were significantly associated (p < 0.001) but were not identical. Higher GPCT and GPQSM grades showed smaller gray matter (p = 0.030 and p = 0.025, respectively) and white matter (p = 0.013 and p = 0.019, respectively) volumes, as well as larger GP volumes (p < 0.001 for both). Among SVD markers, white matter hyperintensity was significantly associated with GPCT (p = 0.006) and brain atrophy was significantly associated with GPQSM (p = 0.032) in at univariable analysis. In multivariable analysis, the normalized volume of the GP was independently positively associated with GPCT (p < 0.001) and GPQSM (p = 0.002), while the normalized volume of the GM was independently negatively associated with GPCT (p = 0.040) and GPQSM (p = 0.035). Conclusion Focal mineral deposition in the GP on CT and QSM might be a potential imaging marker of cerebral vascular degeneration. Both were associated with increased GP volume.
Daya Saing Tembakau Virginia Lokal: Analisis Rantai Nilai

Tembakau Virginia merupakan bahan baku utama industri rokok Indonesia terutama digunakan untuk pembuatan rokok sigaret putih. Meningkatnya impor tembakau Virginia secara langsung maupun tidak langsung berpengaruh terhadap produksi tembakau sejenis di dalam negeri. Studi ini mengkaji kemampuan daya saing tembakau Virginia local dengan menggunakan analisis rantai nilai (value chain). Metode Value Chain Analysis (VCA) digunakan untuk mengetahui keterkaitan yang ada dalam rantai nilai. Data yang dipakai adalah data dari penelitian yang dilakukan di dua daerah yaitu Bojonegoro (Jawa Timur) dam Lombok Timur (Nusa Tenggara Barat). Produksi dalam negeri belum bisa memasok sepenuhnya kebutuhan industri rokok dalam negeri, karena terbatasnya jumlah produksi, rendahnya kualitas tembakau yang dihasilkannya dan kontinyuitas pasokan tembakau. Rantai distribusi yang panjang menyebabkan harga yang tidak kompetitif dan kualiatas yang menurun, sehingga daya saingnya lebih rendah. Kebijakan intensifikasi lahan merupakan pilihan yang harus ditempuh daerah penghasil tembakau dengan terus meningkatkan kualitas tembakau yang dihasilkannya, sehingga produksi dan produktivitasnya meningkat untuk memenuhi pasokan tembakau virginia di dalam negeri.
INDONESIAN EFL TEACHERS’ PERCEPTION ON THE IMPLEMENTATION OF 2013 ENGLISH CURRICULUM

Abstract: Since 2014-2015 academic year, the Ministry of Education and Culture of Republic of Indonesia finally decided to implement the 2013 Curriculum. Restoring character education and improving students’ creative thinking are the main reasons of the new curriculum development. This study employed teachers’ understanding and perception on the implementation of 2013 English Curriculum and identified problems encountered by the teachers in implementing the 2013 English curriculum. Through qualitative design, the study was conducted at one of vocational high schools in Kuningan, West Java. This study reveals that the teacher’s understanding toward 2013 curriculum is quite close to the basic principles of the curriculum and most of teachers claim that the new curriculum cannot be easily implemented at the moment since they find several problems in implementing 2013 English curriculum. They got difficulties in applying new learning revolution, developing assessment rubrics and the shortage of English duration at school will not ensure to improve students’ competence. It also recommended that the teachers should put more efforts on applying the 2013 curriculum in the teaching and learning process by joining any training, workshop and improve their creativity and adapt to the advance of knowledge and technology. Keywords: 2013 English Curriculum, teachers’ understanding, teachers’ perception
ПРОТЕОМНОЕ ПРОФИЛИРОВАНИЕ МОНОЦИТОПОДОБНЫХ КЛЕТОК ЛИНИИ THP-1 И ПРОДУЦИРУЕМЫХ ИМИ МИКРОВЕЗИКУЛ С ПОМОЩЬЮ MALDI-МАСС-СПЕКТРОМЕТРИИ

Extracellular vesicles that are shed from the plasma membranes take an active part in intercellular communication, transporting a wide range of molecules, including proteins, lipids, nucleic acids and carbohy-drates, being of great functional importance. One of the steps to better understanding of distant communica-tions of cells and their regulatory mechanisms is a proteomic study of various extracellular vesicles, including microvesicles and exosomes. Pro-inflammatory cytokines produced by monocytes and individual complement system components play a key role in their specific functioning. The aim of this work was to study proteomic composition of THP-1 monocyte-like cells and their microvesicles. The MALDI-mass spectrometric analysis of electrophoretic protein fractions of cell lysates and microvesicles allowed for identifying 107 proteins that perform various functions. Among 19 determined functional groups, the largest ones comprise transcription regulators and proteins with unknown functions. The smallest functional groups include regulators of cell differentiation and development, proteins participating in immune response and inflammation, cellular receptors and their regulators, transporter and transport regulatory proteins, as well as cell proteins mediating adhesion and matrix structures, processing regulators, proteins of ubiquitin-proteasome system, intracellular signaling, autophagy and exocytosis regulators, chromatin structural proteins, hemostatic regulators, and peptide hormones. An intermediate position is occupied by cytokines and growth factors, enzymes, cytoskeleton and motor proteins, as well as RNA processing and translation regulators. The subsequent DAVID Functional Annotation Clustering analysis allowed for identifying the most common groups distributed by their molecular function, biological processes, and cellular component. Separately, in the microvesicles derived from THP-1 monocyte-like cells, proteins of the immune response and inflammation, cytokines and growth factors, intracellular signaling proteins, cell differentiation regulators and developmental proteins, as well as cell adhesion and matrix proteins were identified among other protein molecules. The data obtained on the partial proteome of THP-1 monocyte-like cells and their microvesicles extend the existing knowledge on distant communica-tions between the cells and suggest new mechanisms of interaction between monocytes/macrophages and their microenvironment.
TACG_A_206076 209..233

1Scott-Ritchey Research Center, Auburn University, Auburn, AL, 36849, USA; 2Department of Anatomy, Physiology, and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, AL, 36849, USA Abstract: The lysosomal storage disorder, GM1 gangliosidosis (GM1), is a neurodegenerative condition resulting from deficiency of the enzyme β-galactosidase (β-gal). Mutation of the GLB1 gene, which codes for β-gal, prevents cleavage of the terminal β-1,4-linked galactose residue from GM1 ganglioside. Subsequent accumulation of GM1 ganglioside and other substrates in the lysosome impairs cell physiology and precipitates dysfunction of the nervous system. Beyond palliative and supportive care, no FDA-approved treatments exist for GM1 patients. Researchers are critically evaluating the efficacy of substrate reduction therapy, pharmacological chaperones, enzyme replacement therapy, stem cell transplantation, and gene therapy for GM1. A Phase I/II clinical trial for GM1 children is ongoing to evaluate the safety and efficacy of adeno-associated virus-mediated GLB1 delivery by intravenous injection, providing patients and families with hope for the future.
and Responses of a Single Dielectric Barrier Plasma Actuator:

This work focuses on the development of a multiscale computational fluid dynamics (CFD) simulation framework for the investigation of the effects of plasma kinetics on the performance of a microscale dielectric barrier discharge plasma actuator (DBD-PA). To this purpose, DBD-PA multi-scale dual-step modelling approach has been implemented, by considering plasma chemistry and flow dynamic. At first, a microscopic plasma model based on the air plasma kinetics has been defined and plasma reactions have been simulated in zero-dimensional computations in order to evaluate the charge density. At this aim computations have been performed using the toolbox ZDPlasKin, which solves plasma reactions by means of Bolsig+ solver. An alternate current (AC) electrical feeding has been assumed: in particular, the sinusoidal voltage amplitude and the frequency have been fixed at 5 kV and 1 kHz at atmospheric pressure and 300 K temperature in quiescent environment. The predictal charge density has been in a macroscopic plasma-fluid model based on Suzen Dual Potential Model (DPM), which has implemented in the computation fluid dynamic CFD code OpenFoam. Hence, as second step, 2D-CFD simulations of the electro-hydrodynamic body forces induced by the microscale DBD-PA have been performed, based on the previously predicted charge densities at the operating conditions. Quiescent flow over a dielectric barrier discharge actuator has been simulated using the plasma-fluid model. The novel modelling framework has been validated with experimental data.
CHEMICAL PROFILES OF LEAF, STEM AND FLOWER OF THEVETIA PERUVIANA (PERS.) K. SCHUM

Thevetia peruviana (Pers.) K. Schum belong to the family Apocynaceae. The leaves, stems and flowers of T. peruviana were investigated for phytoconstituents, quantitative evaluation, nutritional values and antinutrient. Phytochemical screening revealed the presence of alkaloids, saponins, tannins, cardiac glycosides and anthraquinones. Flavonoids and terpenes were found to be present in leaves and stems but not detected in flowers of T. peruviana. However, phlobatannins was completely absent in the three parts. Quantitative evaluation shows moistures content (7.9%, 9.3% and 18%), total ash (6%, 9% and 4.7%), sulphated ash (0.5%, 0.8% and 0.2%) and acid insoluble (0.1%, 0.5% and 0.5%) respectively for the leaves, stems and flowers of T. peruviana. Nutritional analysis revealed protein content (8.10%, 4.21% and 1.2%), fat content (22%, 8% and 43%), crude fibre (10%, 12% and 2%, and carbohydrate content (55.9%, 66.8% and 49.1%). Anti-nutrient revealed hydrogen cyanide (0.011%, 0.201% and 0.301%), soluble oxalate (40%, 30% and 35%, total oxalate (10.00%, 5.00% and 7.00%) and tannins acid (1. 21%, 0.9% and 1.50%) respectively for the leaves, stems and flowers of T. peruviana. The results of the present study further confirm the use of T. peruviana leaves, stems and flowers traditionally for the treatment of different ailments.