Miracle-dz/UniFAR-FTUs huggingface dataset:
Capoeta ekmekciae, a new species of cyprinid fish from northeastern Anatolia (Teleostei: Cyprinidae)

Cyprinid fi shes of the genus Capoeta inhabit mainly fast fl owing streams and rivers of the Levant, Middle East, Caucasus and Southwestern Asia, but some species may also be found in lakes and springs. Their fusiform shape allows them to live in swift waters and their lower jaw with an exposed keratinized edge (sector mouth of Howes, 1982) and lower lip restricted to the corner of the mouth allows them to scrape algae and periphyton on stones in riffl es and rapids. Our fi sh surveys of the Çoruh drainage, northeastern Anatolia, yielded three species of Capoeta. One, easily distinguished by having two pairs of barbels was fi rst identifi ed as C. tinca and its description will appear separately (Turan et al., in press); hereunder, it is called C. sp. aff. tinca. A species with a single pair of barbels, an arched mouth and pleated lips is identifi ed as C. sieboldii. The third species keys out as C. capoeta using the keys in Berg (1949: 576), Karaman (1969: 26), Geldiay & Balik (1996: 360) and Banarescu (1999: 386). All these authors recognise a number of subspecies within C. capoeta. A comparison of the different subspecies shows that several of them in fact are clearly distinct species. Still, the Çoruh material could not be identifi ed with any of the named species we recognize and it is described here as a new species, C. ekmekciae.
A Decentralized Voting System

The target of the project "A Decentralized Voting System" is to investigate whether recent developments in distributed systems can make a decentralized voting system capable of replacing the current systems in place. The current voting systems that are taken into account are primarily democratic electoral voting systems, such as the Swedish national electoral voting system. To remove the single central authority conducting the vote, distributing the responsibility is the primary goal of the project. The voting system developed relies on several trusted entities where the system tolerates conﬂict of interest to a speciﬁed degree. It is built using a software framework for building blockchain applications. The system is capable of managing all aspects of voting except the distribution of a digital voter card. A frontend presents the voting stages of the application but does not oﬀer an interface for election administrators. The system is veriﬁed by several criteria that apply to any voting system, but it is not capable of replacing a large scale election in its current state. Ethical aspects of digitizing and decentralizing are discussed, with particular consideration to societal and environmental impact. Voter turnout change with respect to age, privacy concerns and logistical solutions for the transition to a digitized voting system are also discussed. Finally, a theoretical replacement of the current Swedish electoral system with a decentralized voting system could initially exclude a social group but would reduce cost and environmental impact.
DOXORUBICIN INDUCED CARDIOTOXICITY AND ITS MODULATION BY DRUGS

SUMMARY INTRODUCTION Doxorubicin, an anthracycline commonly usedagainst a broad spectrum of human cancers has wellknown dose dependent cytotoxic effects. Althoughthe mechanism underlying the severe cytoxicity ofdoxorubicin and other anthracyclines are not fullyunderstood, there is evidence that drug toxicity mayensue through drug free radical formation 1 and sub-sequent redox cycle with O 2 resulting in the genera-tion of reactive oxygen species such as superoxideanion, hydroxyl radicals and hydrogen peroxide. Tis-sue with less developed antioxidant defenses suchas heart are particularly susceptible to injury bydoxorubicin induced oxygen radicals 2 . Although antioxidants such as vitamin E 3 and N-acetylcysteine can interrupt this process, only iron chelatorICRF-187 5 has been found to be effective in protect-ing patients from doxorubicin induced cardiotoxicity.Unfortunately the combination of ICRF-187 anddoxorubicin has been observed to be associated withan increase in hematological toxicity thus limiting theclinical application of ICRF -187
The complexity and robustness of gene network inside the story between miRNAs and splicing isoforms in sacred lotus

BACKGROUND. Gene expression is complex and regulated by multiple molecular mechanisms, such as miRNA-mediated gene inhibition and alternative-splicing of pre-mRNAs. However, coordination of interaction between miRNAs with different splicing isoforms, and the role of splicing isoform in response to different cellular environments are largely unexplored in plants. In this study, we analyzed the miRNA and mRNA transcriptome from lotus ( Nelumbo nucifera ), an economically important flowering plant. RESULTS. Through RNA-seq expression analyses among six lotus tissues, the negative regulatory roles of most miRNAs are reflected by their tissue-biased expression and the negative correlation with their targets in expression. Further, the central roles of miRNAs in the gene network was unveiled as there are more frequent interactions between miRNAs and hub isoforms than between miRNAs and non-hub isoforms. Surprisingly, for many genes, their corresponding isoforms were assigned to different co-expressed modules, and they exhibited more divergent mRNA structures including presence and absence of miRNA binding sites, suggesting functional divergence for many isoforms is escalated by both structural and expression divergence. The gene function enrichment analysis of miRNA targeted reveals that miRNAs are involved in regulation of lotus growth and development by regulating plant hormone-related pathway genes. CONCLUSION. Taken together, we carry out a comprehensive and deep analysis between miRNA and mRNA transcriptome to study coordination of interaction between miRNAs with different splicing isoforms. Our study on lotus highlights not only the complicate interactions between the miRNAs and transcript isoforms but also functional divergence of many transcript isoforms from the same locus in plant.
Determinação do ponto de colheita em cultivares de alho.

Com o objetivo de determinar o ponto de colheita de quatro cultivares de alho, foi conduzido experimento no setor de Olericultura da Universidade Federal de Lavras (MG), no delineamento em blocos casualizados, em esquema fatorial 4 x 5, com quatro repeticoes, avaliando quatro cultivares (Gigante Curitibanos, Gravata, Gigante Lavinia e Gigante Roxo) e cinco epocas de colheita (134, 141, 148, 155 e 162 dias apos o plantio). Avaliou-se a produtividade total de plantas, produtividade total de bulbos e caracteristicas fisico-quimicas (teor de solidos soluveis, acidez titulavel e indice de pH). Os resultados obtidos permitiram verificar que as epocas de colheita influenciaram significativamente a producao e as caracteristicas fisico-quimicas. A maxima produtividade foi obtida aos 148 e 156 dias apos o plantio, periodos em que se observou tambem aumento nas concentracoes de solidos soluveis e acidos orgânicos no suco do alho.
Atomistic Simulation of Surface Effects on Magnetic Properties of Alloy Nanomaterials

In the magnetic recording industry, L10 ordered CoPt and FePt nanoparticles have been considered as promising material candidates to advance the recording density beyond 1Tbit/in2. Compared with their bulk form, these alloy nanoparticles exhibit inferior magnetic properties. Surface effects, which are much more pronounced in nanometer scale, have been suggested to contribute to the deteriorated properties. In this work, surface related phenomena in these alloys are explored using atomistic simulation method. Density Functional Theory (DFT) calculations on the surface segregation effect have been performed in cuboidal, cuboctahedral nanoparticles and the related low index surfaces of L10 ordered CoPt alloy. Pt surface segregation to the outermost surface is found thermodynamically favorable in both nanoparticles and crystallographic surfaces. This segregation causes directly the break in structural, chemical ordering and accordingly the reduction in magnetic moment and change in magnetic anisotropy. Under 2nd order perturbation theory, the magnetic anisotropy energy on surface slabs has been associated with the change in d_(z^2 ) state density of surface Co atoms in the minority spin channel. Moreover, the magnetic properties of CoPt and FePt nanoparticles are demonstrated to be affected by particle shape using DFT calculations. This shape dependent magnetism is found correlated with the contraction in atomic spacing and local chemical composition. In addition, the surface spin canting mechanisms are identified for CoPt and FePt cuboctahedral nanoparticles. The different spin canting fashions for these two materials have been reproduced by micromagnetic simulation using Neel’s surface anisotropy model. The relationship between magnetoelastic coupling and Neel’s anisotropy constant in tetragonal lattice has been established. Through the calculation of Neel’s anisotropy constant from first principles, the different spin canting mechanisms have been explained. Finally, the effect of doping Cu, Ag and Au atoms on CoPt and FePt surfaces has been investigated. The Pt surface segregation has been found suppressed by the impurity atoms and the magnetic moment of surface Co/Fe atoms is restored up to the value of corresponding bulk-terminated surface. These additive atoms are proved to be beneficial for the improvement of magnetic properties on CoPt (001) surface and FePt (100) surface.
Texture characteristics of chilled prepared Mandarin fish (Siniperca chuatsi) during storage

ABSTRACT Mandarin fish that have been prepared and chilled have a shelf life of 4 days at 4°C storage, according to the total volatile basic nitrogen values. During the storage process, we observed that the texture characteristics of these fish significantly deteriorated. Certain low-abundance proteins were degraded during the shelf life, which resulted in changes in protein conformation and protein–water interaction patterns. The water-holding capacity of the fish decreased during 4°C storage; nuclear magnetic resonance analysis showed that the binding of water in fish was weakened as shelf storage prolonged and a portion of the free water was also “squeezed” to the surface of the fish in the later stages of storage. A correlation analysis showed that a decrease in the immobilized water content and mobility was associated with quality deterioration of the fish, which may be a result of increase in hydrophobic interaction and disulfide bonds in the fish during storage.
Dry cow therapy

For a long time, administration of intramammary antimicrobials at dry off in each quarter of each cow (blanket ADCT) was advocated as an important measure in mastitis management. Blanket ADCT has been a cornerstone of both the “Five Point Plan” (National Institute for Research into Dairying; NIRD, UK, [1]) and the more recently developed “Ten Point Plan for Mastitis Control” [National Mastitis Council, [2]. The dry period is a crucial period for the cow, with a high risk of new intramammary infections. Moreover, existing infections treated during the dry period have a higher chance of cure compared to treatment during lactation [3]. Therefore, blanket ADCT has been a widely used tool for prevention and treatment of intramammary infections during the dry period and, consequently, blanket ADCT successfully contributed to the control of (sub)clinical mastitis in the next lactation [4].
Polymorphism in Nano-Sized Graphene Ligand-Induced Transformation of Au38-xAgx/xCux(SPh-tBu)24 to Au36-xAgx/xCux(SPh-tBu)24 (x=1-12) Nanomolecules for Synthesis of Au144-xAgx/xCux[(SR)60,(SC4)60, (SC6)60, (SC12)60,(PET)60, (p-MBA)60, (F)60, (Cl)60,(Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60] Nano

Received: May 24, 2017 Accepted: May 25, 2017 Published: May 30, 2017 Our main objective is to develop strategies to exploit the photo-, electro-, and thermal-chemical reactions of these systems to severe as probes to aid in our basic understanding of the mechanistic factors that control molecular interactions and organic reactions at organized monolayer interfaces. Also, the development of new and selective ways of adding or removing functionality to these monolayers is another part of our ongoing efforts. In the present editorial, we have synthesized Au144-xAgx/xCux[(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p-MBA)60, (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60] Nano clusters as anti-cancer Nano drugs and incorporated them onto the surface of gold nanoparticles through the place-exchange reaction. Then, the interfacial reactions of the anchored aldehyde terminus with various nucleophiles have been investigated in some details. Our preliminary results reveal an easy reaction of aldehyde terminus of the organic modified gold nanoparticle with the nucleophiles like aniline, leading to a covalent attachment of the nucleophilic species to the nanoparticle surface.
Correlation of Biochemical Parameters with Cytomorphological grading in Hashimoto’s Thyroiditis

Background: Hashimoto’s thyroiditis (HT) is one of the most common cause of hypothyroidism in iodine sufficient areas. Diagnosis of HT is based on clinical, cytomorphological and biochemical parameters. Fine Needle Aspiration Cytology (FNAC) of thyroid provides a safe and accurate method for diagnosis of HT. Cytological grading of HT helps in assessing the severity of the disease and can predict the thyroid functional status. Methods: Retrospectively, 50 diagnosed cases of HT on FNAC were studied over a period of 6 months in a tertiary care hospital. Clinical, biochemical parameters such as T3, T4 and TSH values were collected. Cytological grading of FNAC smears was done based on Bhatia et al cytological grading system into three grades. These grades were compared with the clinical and biochemical parameters of HT. Result: Of 50 patients, 47 were females. Maximum number of cases were seen between 36 -45 years. Most of the patients presented with goiter. 31 out of 50 (62%) cases were grade II thyroiditis, of them most cases were hypothyroid. 17 out of 50 cases (34%) were grade I thyroiditis, of which most cases were euthyroid biochemically. Conclusion: Higher the grades of HT in cytology the more abnormal are the biochemical parameters. A combined approach of cytological grading along with clinical and biochemical parameters can detect subclinical hypothyroid state which provides a guide to therapy.
Thermal isomerization of (all-E)-lycopene and separation of the Z-isomers by using a low boiling solvent: Dimethyl ether

ABSTRACT Thermal isomerization of (all-E)-lycopene and the separation of generated Z-isomers were conducted using a low boiling solvent, dimethyl ether (DME). Because of the low boiling point (–24.8°C), DME is easily separated from lipids and other residues and is extremely low residual. The efficiency of thermal Z-isomerization of (all-E)-lycopene in DME was almost equivalent to using hexane. The thermally generated lycopene Z-isomers were separated by utilizing the solubility differences among lycopene isomers and a characteristic of DME that allows the solubility of compounds to be controlled by changing the temperature. Finally, a lycopene mixture containing 72.0% Z-isomers was obtained from (all-E)-lycopene.
X-ray powder diffraction data for 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester, C27H28N4O5

1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7- tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester is an important intermediate in the synthesis of the anticoagulant, apixaban. X-ray powder diffraction data for this compound are reported [a = 14.101(4) Å, b = 10.105(6) Å, c = 9.532(7) Å, α = 72.774(1)°, β = 97.356(3)°, γ = 108.237(3)°, unit-cell volume V = 1231.45 Å3, Z = 2, and space group P-1]. No detectable impurities were observed.
Effect of Annealing Atmosphere on Leakage and Dielectric Characteristics of Multiferroic Gallium Ferrite

Mutliferroic and magnetoelectric gallium ferrite (GaFeO3) is plagued by substantial electrical leakage in polycrystalline form. Here, we report on understanding the conduction mechanism in gallium ferrite ceramic samples vis-a-vis processing conditions. The results show that oxygen annealed samples exhibit minimum electrical leakage as compared to air or nitrogen annealed samples suggesting the role of oxygen vacancies on electrical conduction. Detailed time and temperature dependent impedance spectroscopy analysis of the samples showed higher activation energy of conduction in oxygen annealed samples than in air or nitrogen annealed samples. The lower activation energies of 0.3-0.4 eV in nitrogen/air annealed samples were attributed to higher oxygen vacancy concentration while oxygen annealed samples with low oxygen vacancy concentration exhibited higher activation energy of ~0.50 eV (high frequency i.e. grain) and 0.98 eV (low frequency i.e. grain boundary), latter due to superior level of oxygenation at the grain boundaries. Further, X-ray photoelectron spectroscopy revealed that the oxygen vacancies are compensated by the valence fluctuation between Fe2+/Fe3+ ions whose extent is higher in air/nitrogen annealed samples than in oxygen annealed samples. The conduction mechanisms that could be active are most likely to be double ionization of oxygen vacancies and hopping between Fe2+ to Fe3+ states, latter especially in oxygen deficient samples. This article is protected by copyright. All rights reserved.
A first principles study of energetics and electronic structural responses of uranium-based coordination polymers to Np incorporation

Abstract Recently developed coordination polymers (CPs) and metal organic frameworks (MOFs) may find applications in areas such as catalysis, hydrogen storage, and heavy metal immobilization. Research on the potential application of actinide-based CPs (An-CP/MOFs) is not as advanced as transition metal-based MOFs. In order to modify their structures necessary for optimizing thermodynamic and electronic properties, here, we described how a specific topology of a particular actinide-based CP or MOF responds to the incorporation of other actinides considering their diverse coordination chemistry associated with the multiple valence states and charge-balancing mechanisms. In this study, we apply a recently developed DFT-based method to determine the relative stability of transuranium incorporated CPs in comparison to their uranium counterpart considering both solid and aqueous state sources and sinks to understand the mechanism and energetics of charge-balanced Np5+ incorporation into three uranium-based CPs. The calculated Np5++H+ incorporation energies for these CPs range from 0.33 to 0.52 eV, depending on the organic linker, when using the solid oxide Np source Np2O5 and U sink UO3. Incorporation energies of these CPs using aqueous sources and sinks increase to 2.85–3.14 eV. The thermodynamic and structural analysis in this study aides in determining, why certain MOF topologies and ligands are selective for some actinides and not for others. This means that once this method is extended across a variety of CPs with their respective linker molecules and different actinides, it can be used to identify certain CPs with certain organic ligands being specific for certain actinides. This information can be used to construct CPs for actinide separation. This is the first determination of the electronic structure (band structure, density of states) of these uranium- and transuranium-based CPs which may eventually lead to design CPs with certain optical or catalytic properties. While the reduction of the DFT-determined-bandgap goes from 3.1 eV to 2.4 eV when going from CP1 to CP3, showing the influence of the linker, Np6+ incorporation reduces the bandgap for CP1 and CP3, while increasing it for CP2. The coupled substitution of U6+→Np5++H+ reduces the bandgap significantly, but only for CP3.
EVALUATION OF SUSCEPTIBILITY OF TEN THREE-WAY CROSSES OF MAIZE HYBRIDS TO SPIDER MITE TETRANYCHUS URTICAE KOCH INFESTATION IN GHARBIA GOVERNORATE

ten Maize hybrids were evaluated in terms of their relative susceptibility to the two- spotted spider mite Tetranychus urticae Koch during two years 2004-2005 at Gharbia governorate. Population fluctuation of T. urticae on Ten Maize three-way crosses hybrids (i.e. TWC310, TWC311, TWC314, TWC321, TWC322, TWC323, TWC324, TWC327, Nefertity and TWC352), and their relation with weather factors were studies. Susceptibility of different Maize cultivars to spider mites infestation revealed significant differences in movable stages. Influence of leaf chemical components with T. urticae infestation was studied. The study showed that the maize hybrid (Nefertity) recorded the highly significant susceptible to T. urticae infestation with recording averages of 273.96 and 383.5 moving stages/ 20 leaves during the two successive seasons, respectively. Mite population reached its peak on maize during season 2004 at late of August and early September, for all tested hybrids, while in the second year it has two peaks the first in early of July and the second in early of September, for all tested hybrids. Developmental times and reproduction rate of T. urticae were studied on leaves of four maize three way crosses Nefertity, TW327, TW321 and TW310) at laboratory conditions at (28±2°C, 65±5 % RH and 16:8 L: D). Immature developmental time of T. urticae was the longest on TW310 (6.5days) followed by TW321 (6.1 days) than TW327 and Nefertity (5.6 & 6.1 days). Fecundity of T. urticae was 46.6, 36.8, 29.6 and 28.5 eggs/ female on Nefertity, TW327, TW321 and TW310, respectively. The highest net reproductive rate (Ro) was 18.63 female/ female/generation on Nefertity, and the lowest was 10.29 female/ female/ generation on TW310.
Capital Gains Taxes and Expected Rates of Return

Prior literature predicts a positive relation between firms’ expected pre-tax rates of return and investor-level capital gains tax rates. We show that this relation is more nuanced than suggested by prior literature and that in three circumstances the relation can actually be negative. The first circumstance is when a firm’s systematic risk is very high. The second circumstance is when the market risk premium is very high. The third circumstance is when the risk-free rate of return is very low. The circumstances arise because in addition to reducing investors’ expected after-tax cash proceeds, capital gains taxes reduce the risk that investors associate with the expected after-tax cash proceeds.
Acute COVID-19 gene-expression profiles show multiple etiologies of long-term sequelae

Two years into the SARS-CoV-2 pandemic, the post-acute sequelae of infection are compounding the global health crisis. Often debilitating, these sequelae are clinically heterogeneous and of unknown molecular etiology. Here, a transcriptome-wide investigation of this new condition was performed in a large cohort of acutely infected patients followed clinically into the post-acute period. Gene expression signatures of post-acute sequelae were already present in whole blood during the acute phase of infection, with both innate and adaptive immune cells involved. Plasma cells stood out as driving at least two distinct clusters of sequelae, one largely dependent on circulating antibodies against the SARS-CoV-2 spike protein and the other antibody-independent. Altogether, multiple etiologies of post-acute sequelae were found concomitant with SARS-CoV-2 infection, directly linking the emergence of these sequelae with the host response to the virus.