Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Affecting Canine Obesity Seem to Be Independent of the Economic Status of the Country—A Survey on Hungarian Companion Dogs

Simple Summary Obesity is an ever-growing epidemic among people and their pets. Recently, more and more studies investigated the risk factors of dog obesity, but most of them only included data from high-income Western countries. We surveyed Hungarian dog owners about their dogs’ body conditions and social and demographic factors that might affect it. Factors affecting canine body condition seem to be similar to those of high-GDP (Gross Domestic Product) countries, suggesting that these findings are more or less universal. Older dogs are more likely to be overweight/obese than younger ones. Joint activity and sports performed with the owner, even on a hobby level decrease the likelihood of obesity, and the main source of calories (kibble, human leftovers, or raw food) also had an effect on body condition. These findings support that the main risk factors of dog obesity are the ones controlled by the caretakers of dogs, therefore it is important to educate dog owners about how they can prevent the development of this condition. Abstract For a companion dog, the most important environmental factor is the owner, who is responsible for providing everything that is necessary for the health and welfare of the dog. Still, one of the most often compromised measures of an average companion dog is its body condition, with overweight and obese animals representing a growing welfare problem around the world. Using an extensive online survey that was distributed among Hungarian dog owners, we wanted to know whether those obesogenic factors that were identified mostly in high-GDP countries’ pet dog populations would hold their relevance in a much lower average income country as well. We found several associations between the body condition of canine companions and various demographics, environmental and behavioral factors. Older dogs reportedly had an accelerating propensity for being overweight. Joint activity and performing dog sports both reduced the likelihood of being an overweight dog. Main food types also had significant associations with the body condition of dogs—meanwhile, the feeding of commercial dog food (kibble) and/or leftovers of human meals coincided with being overweight, dogs that were fed (fully, or at least partly) with raw food were less likely overweight. In the case of owner-reported behavioral problems, the food-related issues (stealing food, overeating, etc.) were clustered to a dimension together with problem behaviors such as excessive barking and overt aggression. Beyond showing a good agreement with earlier surveys on associated factors with canine obesity, our study revealed some interesting new details that could be used in the prevention of overweight problems in dogs.
Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies

Genetic alterations of leucine-rich repeat kinase 2 (LRRK2), one of the most important contributors to familial Parkinson’s disease (PD), have been hypothesized to play a role in cancer development due to demographical and preclinical data. Here, we sought to define the prevalence and prognostic significance of LRRK2 somatic mutations across all types of human malignancies by querying the publicly available online genomic database cBioPortal. Ninety-six different studies with 14,041 cases were included in the analysis, and 761/14,041 (5.4%) showed genetic alterations in LRRK2. Among these, 585 (76.9%) were point mutations, indels or fusions, 168 (22.1%) were copy number variations (CNVs), and 8 (1.0%) showed both types of alterations. One case showed the somatic mutation R1441C. A significant difference in terms of overall survival (OS) was noted between cases harboring somatic LRRK2 whole deletions, amplifications, and CNV-unaltered cases (median OS: 20.09, 57.40, and 106.57 months, respectively; p = 0.0008). These results suggest that both LRRK2 amplifications and whole gene deletions could play a role in cancer development, paving the way for future research in terms of potential treatment with LRRK2 small molecule inhibitors for LRRK2-amplified cases.
Adverse Impact of Desulfovibrio spp. and Beneficial Role of Anaerostipes spp. on Renal Function: Insights from a Mendelian Randomization Analysis

Background: The microbiota composition is now considered as one of the main modifiable risk factors for health. No controlled study has been performed on the association between microbiota composition and renal function. We applied Mendelian randomization (MR) to estimate the casual impact of eight microbiota genera on renal function and the risk of chronic kidney disease (CKD). Methods: MR was implemented by using summary-level data from the largest-ever genome-wide association studies (GWAS) conducted on microbiota genera, CKD and renal function parameters. The inverse-variance weighted method (IVW), weighted median (WM)-based method, MR-Egger, MR-Robust Adjusted Profile Score (RAPS), MR-Pleiotropy RESidual Sum and Outlier (PRESSO) were applied. A sensitivity analysis was conducted using the leave-one-out method. Results: The Anaerostipes genus was associated with higher estimated glomerular filtration rate (eGFR) in the overall population (IVW: β = 0.003, p = 0.021) and non-diabetes mellitus (DM) subgroup (IVW: β = 0.003, p = 0.033), while it had a non-significant association with the risk of CKD and eGFR in DM patients. Subjects with higher abundance of Desulfovibrio spp. had a significantly lower level of eGFR (IVW: β = −0.001, p = 0.035); the same results were observed in non-DM (IVW: β = −0.001, p = 0.007) subjects. Acidaminococcus, Bacteroides, Bifidobacterium, Faecalibacterium, Lactobacillus and Megamonas had no significant association with eGFR in the overall population, DM and non-DM subgroups (IVW: p > 0.105 for all groups); they also presented no significant association with the risk of CKD (IVW: p > 0.201 for all groups). Analyses of MR-PRESSO did not highlight any outlier. The pleiotropy test, with very negligible intercept and insignificant p-value, also indicated no chance of pleiotropy for all estimations. The leave-one-out method demonstrated that the observed links were not driven by single single-nucleotide polymorphism. Conclusions: Our results suggest an adverse association of Desulfovibrio spp. and a beneficial association of Anaerostipes spp. with eGFR. Further studies using multiple robust instruments are needed to confirm these results.
PORM: Predictive Optimization of Risk Management to control Uncertainty Problems in Software Engineering

Irrespective of different research-based approaches toward risk management, developing a precise model towards risk management is found to be a computationally challenging task owing to critical and vague definition of the origination of the problems. This research work introduces a model called as PROM i.e. Predictive Optimization of Risk Management with the perspective of software engineering. The significant contribution of PORM is to offer a reliable computation of risk analysis by considering generalized practical scenario of software development practices in Information Technology (IT) industry. The proposed PORM system is also designed and equipped with better risk factor assessment with an aid of machine learning approach without having more involvement of iteration. The study outcome shows that PORM system offers computationally cost effective analysis of risk factor as assessed with respect to different quality standards of object oriented system involved in every software projects.
Clinical characteristics of COVID-19 and its comparison with influenza pneumonia

ABSTRACT Objectives To recognise clinical features of COVID-19 pneumonia and its differences from influenza pneumonia. Methods 246 patients were enrolled into COVID-19 cohort and 120 patients into influenza cohort. All data were collected and analysed retrospectively. The variables under focus included demographic, epidemiological, clinical, laboratory and imaging characteristics of COVID-19 pneumonia and comparison were made with influenza pneumonia. Results The COVID-19 cohort included 53.25% female and 46.75% male. Their main symptom was fever; while 28.05% of patients had only initially fever; 21.54% of them remained feverless. After excluding prior kidney diseases, some patients showed abnormal urinalysis (32.11%), elevated blood creatinine (15.04%) and blood urea nitrogen (19.11%). Typical CT features included ground glass opacity, consolidation and band opacity, which could present as characteristic ‘bat wing sign’. Our data showed that male, aged 65 or above, smoking, with comorbidities including diabetes, cardiovascular and kidney diseases, would experience more severe COVID-19 pneumonia. In comparison, COVID-19 cohort showed significantly higher incidence of clustering; the influenza cohort showed higher rate of fever. Both cohorts showed reduced lymphocyte numbers; however, 6 influenza patients showed lymphocytes increased, which was statistical significant compared with COVID-19 cohort. Also, influenza cohort displayed higher white blood cell counts and PCT values. Conclusion There is no significant gender difference in the incidence of COVID-19 pneumonia. It predominantly affects the lung as well as the kidney. Age, smoking and comorbidities could contribute to disease severity. Although COVID-19 is more infectious, the rate of secondary bacterial infection is lower than influenza.
Desempenho de bovinos Nelore e cruzados Blonde d'Aquitaine x Nelore do nascimento ao desmame

This study aimed to evaluate the performance of Nellore and their crosses with Blonde d'Aquitaine (½Nellore + ½ Blonde d'Aquitaine) cattle from birth to weaning kept in grazing system in the State of Alagoas. 1,279 measures of birth weight (BW) and weaning weight adjusted to 210 days (P210) were analyzed for the period between 2005 and 2010. We used SAS® adopting a significance level of 5%. The average for BW and P210 were 31.60 kg and 158.66 kg respectively, for animals Nellore cattle, and 33.05 kg and 167.03 kg, for crossed animals. There was no interaction (P<0.05) between genetic group and sex, for any variable analyzed. We observed significant effects of genetic group, sex and season of birth (P<0.05) on birth weight. The genetic group and sex were significant on the P210. The effect of calving season was significant on birth weight, but no effect on P210 was observed, probably due to climatic variation found in the region. Males had higher body weights (P<0.05) showing sexual dimorphism. The Nellore cattle are superior to crossbred animals in all characteristics considered, providing even heavier calves at birth, without, however, presenting dystocic deliveries. The crossbred animals are also suitable in relation to large breed adaptation to climatic conditions and management which were submitted, making it an excellent option for crosses in the Northeast, in climatic conditions similar to this study.
Genetic diversity and structure of the Chinese lake gudgeon (Sarcocheilichthys sinensis)

Abstract Mitochondrial DNA cytochrome b and d-loop sequences (2,137 bp) in 65 specimens of Sarcocheilichthys sinensis from five populations were identified as two lineages (I and II). The pairwise genetic distance between lineages I and II was 1.94%. SAMOVA analyses suggested that the best grouping occurred at three groups, Yangtze, Qiantang and Minjiang Rivers. High haplotype diversity (0.949) and low nucleotide diversity (θ π = 1.067%) were detected. The results of the neutrality tests, mismatch distribution and approximate Bayesian computation (ABC) did not support demographic expansions. The results of phylogenetic analysis, statistical dispersal-vicariance analysis (S-DIVA), ABC, MIGRATE-N and the time to the most recent common ancestor (TMRCA) indicated two colonization routes. First, before the Wuyi Mountains lifted, S. sinensis dispersed from the Yangtze River to the Minjiang River. Second, during glaciation, the continental shelf was exposed, which contributed to the dispersion of populations from the Yangtze River.
Perceptions of the Food Environment and Access among Predominantly Black Low-Income Residents of Rural Louisiana Communities

Food insecurity in rural settings is complex and not fully understood, especially from the perspective of low-income and Black residents. The goal of this study was to use qualitative methods to better understand experiences with food access and perceptions of the food environment among low-income, predominately Black rural Louisiana residents in the United States. Data were collected from focus group discussions (FGD) and focus group intake forms. Study participants were all rural residents eligible to receive at least one nutrition assistance program. FGD questions focused on perceptions of the food environment, with an emphasis on food access. Participants (n = 44) were predominately Black and female. Over half (n = 25) reported running out of food before the end of the month. Major themes included: store choice, outshopping, methods of acquiring foods other than the grocery store, and food insecurity. Concerns around price, quality, and transportation emerged as factors negatively impacting food security. Understanding residents’ perceptions and experiences is necessary to inform contextually appropriate and feasible policy and practice interventions that address the physical environment and social conditions that shape the broader physical food environment in order to achieve equitable food access and food security.
Incidence and characteristics of acute and overuse injuries in elite powerlifters

Abstract The aim of this study was the analysis of incidence and type of injury in German elite powerlifters. A total of n = 57 competitive athletes of the German powerlifting federation completed a retrospective survey regarding acute and overuse injuries. With 224 total injuries, a mean incidence of 1.51 per 1.000 h or 0.49 per year was calculated. Most injuries affected the lower back (20.5%), elbow (11.2%), pelvic region (10.3) and the shoulder (9.8%). Regarding the type of injury acute inflammation (25.9%), muscle strains/sprains (20.5%) and skin lesions (13%) dominated. The mean incidence significantly declined with increasing age and training experience of the athlete. Athletes using a bench press shirt and various regenerative methods like sauna or swimming also showed decreased injury rates. There was no significant correlation between body weight, height or gender and injury incidence. Compared to other sports, the incidence of injuries and overuse syndromes is still low in powerlifting. Nonetheless, appropriate strategies in training, equipment, prevention and regeneration should be employed to protect the athlete from injury.
Travel Market Switzerland 2004 - Basic Report and Variables Overview

In 2004, for the 16th time since 1972, a survey on the travel behaviour of the Swiss population was conducted. The database resulting from this project (Travel Market Switzerland 2004) is still the most extensive one on private trips of the Swiss population. This report gives an overview on - Method/ procedure of data collection (cf. chapter 2), and - Results (cf. chapter 3). Furthermore, 1998 research on the clustering of travel situations based on motivation factors was replicated as part of this report (Market segmentation by motivation: results of 1998 research revisited). Please refer to chapter 4. To give insight into previous publications on Travel Market Switzerland, we made a compilation of all related papers published by the authors of this report; please refer to chapter 5. Finally, a list of all currently available variables gives an impression of data available for research (cf. chapter 6).
A Dairy Product to Reconstitute Enriched with Bioactive Nutrients Stops Bone Loss in High-Risk Menopausal Women without Pharmacological Treatment

Osteoporosis is a multifactorial disease characterized by the loss of bone mass and deterioration of the internal structure of the bone, increasing the risk of fractures, and is becoming an economic and social problem. The main treatment is pharmacological, however, the population demands other therapies, such as foods with nutrients beneficial to bone health. Seventy-eight healthy menopausal women at risk of osteoporosis or untreated osteopenia were recruited for a randomized, parallel, double-blind clinical trial with two intervention groups: one group consumed a serving a day of the experimental enriched product (experimental group (EG)) and the other group (control group (CG)) consumed the same product without enrichment. The main objective was to compare the effect of consuming a dairy preparation to reconstitute, similar to yogurt when prepared, enriched in calcium, vitamin D, vitamin K, vitamin C, zinc, magnesium, L-leucine and probiotic (Lactobacillus plantarum 3547) on bone metabolism markers for 24 weeks. The EG showed a significantly increased bone mass compared to the CG (0.01 ± 0.03 vs. −0.01 ± 0.03 kg; p < 0.05). In addition, the EG maintained their bone mineral density (BMD) compared to the CG, whose BMD significantly decreased at the end of the study. For biochemical markers, the EG significantly increased the serum levels of the N-terminal propeptide of type I collagen (P1NP) bone formation marker (13.19 ± 25.17 vs. −4.21 ± 15.62 ng/mL; p < 0.05), and decreased the carbo-terminal telopeptide of type I collagen (CTx) bone resorption marker compared to the CG (−0.05 ± 0.19 vs. 0.04 ± 0.14 ng/mL; p < 0.05). On the other hand, the EG exhibited a significantly decreased systolic and diastolic blood pressure compared to the start of the study. Finally, the EG significantly increased their dietary calcium and vitamin D intake compared to the CG. In conclusion, the regular consumption of a dairy product to reconstitute enriched with bioactive nutrients improves bone health markers in menopausal women at risk of osteoporosis without pharmacological treatment.
Influence of Pasteurization and Storage on Dynamic In Vitro Gastric Digestion of Milk Proteins: Quantitative Insights Based on Peptidomics

It is important to evaluate the nutritional quality of milk during the shelf-life, especially during home storage, from a consumer viewpoint. In this study, we investigated the impact of pasteurization (85 °C/15 s) and subsequent storage (at 4 °C for 7 days) on the coagulation behavior of milk and protein digestibility in a dynamic in vitro gastric digestion test. A high level of hydration in curd formed in pasteurized milk upon 7-day cold storage compared to raw and pasteurized milk, indicating fast pepsin diffusion in the interior of curds, increasing the hydrolysis rate. The digesta collected at various time points throughout the gastric digestion were studied using o-phthaldialdehyde (OPA), sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), liquid chromatography tandem mass spectrometry (LC-MS/MS), and amino acid analysis. These results showed that milk proteins were hydrolyzed quickly upon a long period of cold storage. Additionally, qualitative and quantitative results obtained using LC-MS/MS exhibited significant differences between samples, especially in pasteurized milk upon cold storage. Processing and storage played a decisive role in bioactive peptide generation. Such knowledge could provide insights into and directions for the storage of pasteurized milk for further clinical studies on protein bioavailability and the generation of bioactive peptides for desired health outcomes.
Not Only Habitat But Also Sex: Factors Affecting Spatial Distribution of Little Bustard Tetrax tetrax Families

Abstract Species distribution patterns are determined not only by habitat preferences but also by biotic factors. Particularly, the presence of conspecifics may yield different types of benefits and costs for the individuals involved. This study analyses the spatial distribution of Little Bustard families during the breeding season in relation to the distribution of male core areas in three Spanish populations of the species. A compositional analysis is used to evaluate habitat selection and the habitat types most preferred by females with offspring. Spatial analyses were performed to evaluate the proximity of Little Bustard families to male core areas and male displaying sites. The habitat selection pattern was similar between regions, with semi-permanent vegetation and stubbles as most preferred habitats while others, such as ploughed land, were avoided. Families were located closer to male core areas than expected by chance and were spatially associated to male displaying sites. Little Bustard females may obtain different benefits from this spatial association such as access to more food resources and chances for second matings after a clutch loss. Also in stubbles, the capture of prey by chicks would be easier and semi-permanent habitats would serve as shelter. These results highlight the importance of intraspecific interactions in the definition of the habitat selection pattern of females and families. This study shows how spatial point pattern analysis may be a useful tool for integrating landscape and behavioural ecology.
10-Year Longitudinal Changes in Fitness Parameters in Physiotherapy Students

Introduction The aim of this study is to examine changes in the chosen morphological characteristics, motor conditioning, and coordination skills in physiotherapy undergraduates at a medical university in Bydgoszcz in the first decade of the millennium. We assume prevalence of a secular trend in values of morphological characteristics; however, characteristics of motor skills, particularly fitness levels, will remain relatively unchanged. Materials and Methods The study included young people studying physiotherapy at the medical university of Bydgoszcz 2001-2010. Basic morphological features, including waist and hip circumferences, were measured, and BMI and WHR were calculated. The Cooper test and marching over a distance of two kilometers were employed to determine endurance; right and left spinning coordination was assessed by Starosta test. Calculated Mollison indicators were used in the evaluation of dimorphic differences in subsequent observation time. Statistics. Data are presented as mean with the standard deviation. Groupwise comparison was performed with Student's t-test and linear relationships with Pearson's r. Linear covariance models (ANCOVA) were built as theoretical models. Statistical significance was set at alfa = 0.05. Based on the correlation between the data and the corresponding normal score used, the Shapiro-Wilk test is the best choice for testing the normality of data. Variables were excluded if they exceeded the tolerance level for multicollinearity. Analysis was performed with Statistica 10. Results The study demonstrated a rising number of male students (from 13,3% to 39,2%, chi2 = 10, 13; p = 0,001) and a decrease in age of students overall but no significant changes (from 22, 25 ± 0, 75 to 20, 42 ± 1, 7; F = 32, 9; p < 0,001) in their morphological characteristics and their dimorphic differences (average results for males: BMI, from 22, 25 ± 1, 94 to 26, 27 ± 3, 56; WHR index, from 0, 78 ± 0, 06 to 0, 85 ± 0, 06; average results for females: BMI, from 20, 79 ± 2, 11 to 22, 19 ± 3, 83; WHR index, from 0, 7 ± 0, 04 to 0, 75 ± 0, 15). An overall improvement in endurance was found; however, coordination, especially amongst women, had deteriorated (turn right, from 377,1 ± 48, 1 to 343,1 ± 23, 3; turn left, from 375,0 ± 5, 61 to 345,6 ± 43, 1). We observed multidirectional changes in the analyzed motor skills and most of them were statistically significant. Conclusions Longitudinal study of physiotherapy students revealed no differences in morphological and dimorphic characteristics and multimodal changes in assessed motor skills, thus highlighting a need for further research into the identification of their causes. Moreover, a requirement for entry motor skills assessment and curriculum reorientation towards delivery of a broader scope of physical education was suggested.