Miracle-dz/UniFAR-FTUs huggingface dataset:
GNRH antagonists in oocyte donor cycles: the key to safe, simple and efficient stimulation protocols

Background: Since its first description in 1984 the indications of oocyte donation (OD) has widened considerably which has led to a continuous increase in the number of OD treatment cycles performed worldwide. Although this treatment option secured the highest pregnancy rates for the recipients of donor oocytes increased efforts were also made to achieve safer and simpler treament protocols for the oocyte donor. During the last decade with the advent and increased use of the GnRH antagonists this new pharmacological agent was also explored in ovarian stimulation protocols specifically tailored for oocyte donors. Materials: The present doctoral thesis summarizes the findings of two recently published articles (2010) on the application of GnRH antagonists in the ovarian stimulation of oocyte donors. Furthermore the findings of another four strictly related articles (published in high-impact international journals between 2006 and 2009) are also discussed. The primary objectives were: 1. to compare efficiency of GnRH antagonist protocols in comparison with GnRH agonist-based protocols in the context of oocyte donation by means of a systematic review and meta-analysis and 2. to illustrate that GnRH antagonist protocols substantially increase the safety of ovarian stimulation for oocyte donors by reducing or even eliminating the incidence of moderate/severe ovarian hyperstimulation syndrome (OHSS). Results: 1. A meta-analysis of eight randomized clinical trials (RCTs) performed in oocyte donors undergoing stimulation with GnRH antagonists showed no significant difference in the number of retrieved oocytes or recipient ongoing pregnancy rate when compared with GnRH agonists. 2. A prospective, follow-up study of a group of high risk oocyte donors showed that early onset moderate/severe OHSS was completely eliminated after triggering with a GnRH agonist. Furthermore the findings of four studies supporting the above conclusions are also presented. Conclusions: In the context of oocyte donation the GnRH antagonist based ovarian stimulation protocols are equally efficient compared to down regulation by GnRH agonists. The induction of final oocyte maturation can be successfully achieved by a GnRH agonist instead of hCG which practically eliminates early-onset moderate/severe OHSS. The proposed ovarian stimulation protocol should be preferentially used because it permits the simplification and considerably increases the safety of ovarian stimulation for oocyte donors.
Nanoscale etching of perovskite oxides for field effect transistor applications

The etching of epitaxially grown perovskite oxide BaSnO3 (BSO) and BaTiO3 (BTO) thin films is studied using Cl-based (BCl3/Ar) and F-based (CF4/Ar) plasma chemistries in an inductively coupled plasma reactive ion etching (ICP-RIE) system for the development of field effect transistors (FETs). It is found that the BCl3/Ar process has a time-independent and a higher etch rate and creates a smooth etched surface, while the etch rate of BSO and BTO in CF4/Ar plasma decreases with the etching time duration. For the BCl3/Ar etching process, the etch rate increases with both ion density and ion energy, suggesting the combination of chemical plasma etching and physical ion sputtering mechanisms. Using the Cl-based etching process, BaSnO3 and BaTiO3 heterojunction FETs are developed. The devices with a gate length of 1.5 μm have a saturation current density of 287.6 mA/mm, a maximum transconductance of gm = 91.3 mS/mm, an FET mobility of 45.3 cm2/V s, and a threshold voltage of −1.75 V. The etching processes developed in this work will enable further development of perovskite oxide heterostructure electronic devices.The etching of epitaxially grown perovskite oxide BaSnO3 (BSO) and BaTiO3 (BTO) thin films is studied using Cl-based (BCl3/Ar) and F-based (CF4/Ar) plasma chemistries in an inductively coupled plasma reactive ion etching (ICP-RIE) system for the development of field effect transistors (FETs). It is found that the BCl3/Ar process has a time-independent and a higher etch rate and creates a smooth etched surface, while the etch rate of BSO and BTO in CF4/Ar plasma decreases with the etching time duration. For the BCl3/Ar etching process, the etch rate increases with both ion density and ion energy, suggesting the combination of chemical plasma etching and physical ion sputtering mechanisms. Using the Cl-based etching process, BaSnO3 and BaTiO3 heterojunction FETs are developed. The devices with a gate length of 1.5 μm have a saturation current density of 287.6 mA/mm, a maximum transcond.
Common and Idiosyncratic Inflation

We use a dynamic factor model to disentangle changes in prices due to economy-wide (common) shocks, from changes in prices due to idiosyncratic shocks. Using 146 disaggregated individual price series from the U.S. PCE price index, we find that most of the fluctuations in core PCE prices observed since 2010 have been idiosyncratic in nature. Moreover, we find that common core inflation responds to economic slack, while the idiosyncratic component does not. That said, even after filtering out idiosyncratic factors, the estimated Phillips curve is extremely flat post-1995. Therefore, our results suggest that the flattening of the Phillips curve is the result of macroeconomic forces.
Optimization of energy distribution in smart grids

Het elektriciteitsnet verandert ingrijpend als gevolg van de ontwikkelingen op het gebied van informatietechnologie en het sterk groeiende aandeel van duurzame energiebronnen. Deze transitie wordt veelal aangeduid met de term “Smart Grid”, waarin een actievere rol voor eindgebruikers binnen het distributienetwerk mogelijk is en waar eindgebruikers “prosumers” kunnen worden door zowel op kleine schaal duurzame energie op te wekken als energie op te slaan. Behalve het verbruik van energie produceert een prosumer ook energie dat verhandeld kan worden met andere eindgebruikers, waarmee het traditionele gebruikersmodel wordt verstoord. Om de transitie naar een distributienetwerk dat primair door de prosumers wordt geleid te faciliteren, stellen we een nieuwe strategie voor om de peer-to-peer energiedistributie binnen het Smart Grid te optimaliseren. Deze strategie gaat uit van de betrokkenheid van prosumers en houdt daarbij rekening met de energie die verloren gaat tijdens het energietransport evenals de structuur en fysieke restricties van het distributienetwerk. We evalueren de strategie op basis van verschillende synthetische distributienetwerken waarvan de topologie gebaseerd is op een van de volgende modellen: radial, random graph, small-world en complete graph. Daarnaast onderzoeken we een scenario waarin prosumers beschikken over de mogelijkheid om energie op te slaan. Nadat prosumers aan hun eigen vraag hebben voldaan, kan een eventueel overschot aan energie worden verkocht of opgeslagen om later te gebruiken of te verkopen. Hiervoor introduceren we een model van het opslagsysteem om de energiekosten van de prosumers die een bijdrage leveren aan de peer-to-peer energiedistributie te optimaliseren.
Performance, Body Water Balance, Ingestive Behavior and Blood Metabolites in Goats Fed with Cactus Pear (Opuntia ficus-indica L. Miller) Silage Subjected to An Intermittent Water Supply

This study evaluated the performance, body water balance, ingestive behavior and blood metabolites in goats fed with cactus pear silage subjected to an intermittent water supply. Thirty-six goats were distributed in a randomized block design arranged as a 3 × 3 factorial with cactus pear silage in the goats’ diet (on a 0%, 21% and 42% dry matter-DM basis) and water offer frequency (ad libitum, and 24 and 48 h water restrictions). There was an interaction only between the cactus pear silage level and water offerings for drinking water. Goats fed 42% cactus pear silage had greater intake of non-fibrous carbohydrates, energy, Ca, Mg and Na minerals, water intake, urinary water excretion, body water retention and nutrient digestibility. Cactus pear silage inclusion up to a 42% rate reduced eating and ruminating time and increased the time spent idling as well as the eating and the ruminating efficiency rate. Water restriction at 48 h reduced drinking water intake. Performance and blood metabolites were not affected by cactus silage inclusion or water offering. Cactus pear silage inclusion at up to 42% for goats is recommended during periods of water shortage in semiarid and arid regions because it improves eating, the ruminating efficiency rate, and body water retention; cactus pear silage inclusion at this rate reduces water consumption and it does not affect the performance or health of the animals.
Between the Highland Polity and Philistia: The United Monarchy and the Resettlement of the Shephelah in the Iron Age IIA, with a Special Focus on Tel ʿEton and Khirbet Qeiyafa

The Shephelah, one of Judah’s 8th century b.c.e. settlement hubs, was sparsely settled during the Iron Age I, when only a small Canaanite enclave survived in its eastern part. The resettlement of the Shephelah, beginning during the Iron Age I–II transition and lasting over 200 years, was a complex process that had two different facets. The first, better-known facet is the gradual establishment of dozens of new sites, the vast majority of which had clear connections to the highlands polity (e.g., Lachish, Tel Zayit, Tel Burna). The second, less-discussed facet is the transformations experienced by the few settlements that existed in the region in the Iron Age I, most notably Tell Beit Mirsim, Beth-Shemesh, Tel ʿEton, and Tel Halif. After presenting background data, the article will offer a detailed reconstruction of the processes through which the Shephelah became part of the highland polity, with a special focus on Tel ʿEton and on the enigmatic, earlier, and short-lived site of Khirbet Qeiyafa. The paper will conclude with a detailed refutation of the recent suggestion that the small Iron Age I Canaanite enclave that existed in the eastern Shephelah developed into a large Iron Age IIA Canaanite polity.
Safety and Efficacy of Imiquimod in the Treatment of Infantile Hemangioma; a Systematic Review and Meta-Analysis

Reviewed By: Dr. K. Akarowhe Department: Reviewer/CMRO ABSTRACT Objective: To study the safety and efficacy of imiquimod in the treatment of infantile hemangioma (IH). Method: Systematic search was conducted in nine electronic databases for selecting relevant articles reporting the safety and efficacy of imiquimod as a therapeutic agent for treatment of IH. Meta-analysis was used to pool the results. Results: Of total 180 records screened, we included 9 studies for this systematic review and meta-analysis. About one-fifth of the patients (20.9%) have showed clinical resolution with 95% confidence interval (CI) of 11.8% to 34.1%. Regarding IH type, superficial type showed the highest rates of both clinical resolution and excellent response rates with 31.2% (95% CI= 16.6% to 50.8%) and 26.5% (95% CI= 11.6% to 49.6%), respectively. A relatively high prevalence of any side effects with 63.1% (95% CI= 47.6% to 76.3%) has been reported. The highest reported side effect was crustation (44.1%; 95% CI= 27.8% to 61.8%). Conclusion: Imiquimod is effective in the treatment of superficial IH and it is associated with local side effects.
Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt–Jakob disease brain

Abstract Astrocytes are glial cells of the central nervous system that become reactive under conditions of stress. The functional properties of reactive astrocytes depend on their stimulus that induces the upregulation of specific genes. Reactive astrocytes are a neuropathological feature of prion disorders; however, their role in the disease pathogenesis is not well understood. Here, we describe our studies of one polarization state of reactive astrocytes, termed A1 astrocytes, in the frontal cortex region of 35 human sporadic Creutzfeldt–Jakob disease brains encompassing a range of molecular sub-types. Examination of two mRNA markers of A1 astrocytes, C3 and GBP2, revealed a strong linear correlation between the two following their log-normalization (P = 0.0011). Both markers were found upregulated in the sporadic Creutzfeldt–Jakob disease brain compared with age-matched control tissues (P = 0.0029 and 0.0002, for C3log and GBP2log, respectively), and stratifying samples based on codon 129 genotype revealed that C3log is highest in homozygous methionine and lowest in homozygous valine patients, which followed a linear trend (P = 0.027). Upon assessing other disease parameters, a significant positive correlation was found between GBP2log and disease duration (P = 0.031). These findings provide evidence for a divergence in the astrocytic environment amongst patients with sporadic Creutzfeldt–Jakob disease based on molecular sub-type parameters of disease. While more research will be needed to determine the global changes in the genomic profiles and resulting functional properties of reactive astrocytes in disease, considering the evidence demonstrating that A1 astrocytes harbour neurotoxic properties, the changes seen in C3log and GBP2log in the current study may reflect differences in pathogenic mechanisms amongst the sporadic Creutzfeldt–Jakob disease sub-types associated with the A1 polarization state.
Study of role of oral probiotics in patients on ventilator in paediatric Intensive Care Unit at tertiary care center

Probiotics are defined as ‘live microorganisms that confer a health benefit on the host when administered in adequate amounts’. Probiotics may affect other body sites in addition to the GI tract (such as the oral cavity, respiratory tract, urogenital tract and skin), and they can have applications in a variety of populations, including healthy individuals, children, the elderly, and immunocompromised and genetically predisposed individuals. The normal intestinal microbiota of critically ill patients is altered and replaced by pathogens for a number of reasons. Any significant insult to the gut or alteration to its microbiota is likely to play a role in promoting systemic inflammation and infection in the critically ill population. Guidelines on probiotics, produced by the World Gastroenterology Organization, states that gut microbiota may affect several non-gastrointestinal conditions. Numerous studies have shown that probiotics can reduce bacterial vaginosis, prevent atopic dermatitis in infants, reduce oral pathogens and dental caries, and ABSTRACT
The Effect Of Worm Density In Vermicomposting Of Vegetable Waste And Cow Manure Using Lumbricus Rubellus

Cibodas Village, Pasirjambu district, Bandung Region is a place that has high potential in developing dairy industry and the producer of vegetables. The high interest of the citizens to plant various vegetables and raising cattle cause an increase in the amount of waste production. Cow manure (CM) and vegetable waste (VW) are mostly thrown into the river and made the water turned to green and thus contains a lot of bacteria. One way to handle this waste is to use vermicomposting method using Lumbricus rubellus. The purpose of this study was to observe the speed of waste degradation and quality of compost with variations of worm density and variations of row material. The research method using three variations of the worm density (1.5kg/m2; 2kg/m2; 2.5kg/m2), 4 variations of raw materials (100%CM, 100%VW, 50%CM and 50%VW, 30%CM and 70%VW). Biodegradation calculation is performed by calculating the percentage difference before and after the process of composting. The results showed that the worm density effect on the biodegradation of organic matter. Worm density 1.5 kg/m2 is the highest earthworm biomass and also giving a lower number of vermicompost. Variations materials 30%CM and 70%VW shows that the Lumbricus rubellus worm has high potential to reduce waste into compost and the analysis result showed that nitrogen, phosphorus, potassium and C/N ratio has met the standard of SNI 19-7030-2004 (2,201%; 1,348%; 2,741%; 9,523). Furthermore, because of the analysis result has fit into the standard, it can be known that vermicomposting can be used for the growth and development of healthy plants. Index of Terms: Biodegradation, Cow manure, Lumbricus rubellus, Vegetable waste, Vermicomposting, Worm density ————————————————————
ATTACHED, DETACHED and WITHOUT inhaler technique coaching tools to optimize pMDI use competence, asthma control and quality-of-life in asthmatic adults

Background Poor pressurized metered dose inhaler (pMDI) technique is prevalent, which will diminish treatment gains. In a two-visit study, two novel pMDI training devices with feedback mechanisms; Trainhaler (THR) and Flo-Tone CR (FTCR), were evaluated alongside the traditional verbal inhaler training (VT) in asthma outpatients. Methods On visit 1, 18–60 year-old asthmatics with incorrect pMDI use [including peak inhalation flow (PIF) >60 L/min] signed consent and baseline pMDI technique, lung function, asthma control and quality-of-life were measured. Participants were randomized to receive pMDI technique training using VT, THR or FTCR. One hour post-training, the pMDI coordination and PIF were re-assessed. The THR and FTCR patients were given their assigned tools to take home to facilitate regular training. All outcomes were re-evaluated 6–8 weeks later (visit 2). Results Ninety-two asthmatics completed visit 1 (46 attended visit 2). Pre-training, 61.3% (VT), 61.5% (THR) and 65.0% (FTCR) patients similarly made ≥2 pMDI errors with mean PIFs 175.2, 187.1 and 158.9 L/min, respectively. pMDI use was significantly improved 1 h post-training. The subjects that completed visit 2 had significantly, yet equally, maintained the improved inhaler use; only 28.0% (VT), 26.2% (THR) and 21.7% (FTCR) patients made ≥2 pMDI errors with PIF improvements; 115.3, 94.6 and 96.1 L/min, respectively. Clinical outcomes remained comparable. Conclusions VT improves the overall pMDI technique, however patients gradually forget their VT. The THR and FTCR devices are retained by the patients as their self-monitoring, all-time personal trainers that boost and maintain their VT between routine clinic visits.
Prevalence of Melanin Pigmentation in a Yemeni Population and its Relation to Some Risk Factors

Objective: The present study aimed to explore the prevalence of melanin pigmentation in a sample of Yemeni population and its relation to some possible risk factors. Material and Methods: This crosssectional study was performed on 440 patients attending a private clinic. Printed questionnaires were introduced to the patients and a clinical examination was performed for each patient. The questionnaire included questions regarding demographic data, and questions regarding some common habits such as smoking, khat chewing and consuming of hot drinks. Melanin pigmentation was assessed regarding its presence, most affected areas and the numbers of affected quadrants. The data were managed and analyzed using SPSS software program. Descriptive statistics and inferential statistics were performed and the associations of melanin with risk factors were evaluated at P value 25 years, and darkskinned patients. Regarding habits, smoking, khat chewing and hot drink consumption habits showed significant associations with melanin pigmentation. Whereas the association of khat chewing and hot drinks alone with melanin pigmentation showed no significant relationship with melanin pigmentation while, the merge effects of khat chewing and smoking habits together with melanin pigmentation showed significant relationship with melanin pigmentation. Conclusion: It can be concluded that Yemeni people had high prevalence of melanin pigmentation with more prevalence of CL I type. Males, patients > 25 years and dark-skinned patients showed more prevalence of melanin pigmentation. Smoking, khat chewing and hot drinks consuming habits had significant associations with melanin pigmentation. KEYWORDS Melanin; Yemeni; Smoking; Khat chewing; Risk.
Scenario Selection for Iterative Stochastic Transmission Expansion Planning

Reliable transmission expansion planning is critical to power systems’ development. To make reliable and sustainable transmission expansion plans, numerous sources of uncertainty including demand, generation capacity, and fuel cost must be taken into consideration in both spatial and temporal dimensions. This paper presents a new approach to selecting a small number of high-quality scenarios for transmission expansion. The Kantorovich distance of social welfare distributions was used to assess the quality of the selected scenarios. A case study was conducted on a power system model that represents the U.S. Eastern and Western Interconnections, and ten high-quality scenarios out of a total of one million were selected for two transmission plans. Results suggested that scenarios selected using the proposed algorithm were able to provide a much more accurate estimation of the value of transmission plans than other scenario selection algorithms in the literature.
Acetaldehyde production by Rothia mucilaginosa isolates from patients with oral leukoplakia

ABSTRACT Rothia mucilaginosa has been found at high abundance on oral leukoplakia (OLK). The ability of clinical isolates to produce acetaldehyde (ACH) from ethanol has not been investigated. The objective of the current study was to determine the capacity of R. mucilaginosa isolates recovered from OLK to generate ACH. Analysis of R. mucilaginosa genomes (n = 70) shows that this species does not normally encode acetaldehyde dehydrogenase (ALDH) required for detoxification of ACH. The predicted OLK metagenome also exhibited reduced ALDH coding capacity. We analysed ACH production in 8 isolates of R. mucilaginosa and showed that this species is capable of generating ACH in the presence of ethanol. The levels of ACH produced (mean = 53 µM) were comparable to those produced by Neisseria mucosa and Candida albicans in parallel assays. These levels were demonstrated to induce oxidative stress in cultured oral keratinocytes. This study shows that R. mucilaginosa can generate ACH from ethanol in vitro at levels which can induce oxidative stress. This organism likely contributes to oral ACH levels following alcohol consumption and the significance of the increased abundance of R. mucilaginosa in patients with potentially malignant disorders requires further investigation.
Characterization and expression analysis of four members genes of flavanone 3-hydroxylase families from Chamaemelum nobile

Chamaemelum nobile is a traditional Chinese herbal medicine, whose secondary metabolites used in the pharmacology of Chinese medicine. Among them, the flavonoids have great research value. Flavanone 3hydroxylase (F3H) is one of the core enzymes in the early steps of flavonoid biosynthesis. This study aimed to elucidate the structures, functions, and expression levels of F3H families from C. nobile. Four members of the F3H family were screened from C. nobile transcriptome data and performed bioinformatics analysis. Results showed that CnF3H1~4 had a high similarity with the other F3H plants, and all genes contained two conserved isopenicillin N synthase-like and oxoglutarate/iron-dependent dioxygenase domains. Further analysis revealed that the four CnF3H proteins contained some differences in binding sites. The results of secondary and 3-D structures displayed that the composition and proportion of the four CnF3H secondary structures were basically the same, and their 3D structures were consistent with the secondary structures. The phylogenetic tree displayed that CnF3H2, CnF3H3, and CnF3H4 were grouped with Asteraceae. The expression patterns of CnF3Hs in the roots, stems, leaves, and flowers of C. nobile were evaluated using the value of RPKM. The results indicated that CnF3Hs had significant difference in the expression of different tissues. Especially, CnF3H1~3 and CnF3H4 had the highest expression levels in the flowers and roots, respectively. Hence, CnF3Hs played a significant role in the flavonoid metabolism.