Miracle-dz/UniFAR-FTUs huggingface dataset:
Balance Therapy With Hands-Free Mobile Robotic Feedback for At-Home Training Across the Lifespan

Providing aging adults with engaging, at-home balance therapy is essential to promote long-term adherence to unsupervised training and to foster independence. We developed a portable interactive balance training system that provides real-world visual cues on balance performance using wobble board tilt angles to control the speed of a robotic car platform in a three-dimensional environment. The goal of this study was to validate this mobile balance therapy system for home use across the lifespan. Twenty younger (18-39 years) and nineteen older (58-74 years) healthy adults performed balance training with and without visual feedback while standing on a wobble board instrumented with a consumer-grade inertial measurement unit (IMU) and optical motion tracking markers. Participants performed feedback trials based on either the robotic car’s movements or a commercially-available virtual game. Wobble board tilt measurements were highly correlated between IMU and optical measurement systems (<inline-formula> <tex-math notation="LaTeX">$\text {R}{>}{0.84}$ </tex-math></inline-formula>), with high agreement in outcome metrics (<inline-formula> <tex-math notation="LaTeX">$\text {ICC}{>}{0.99}$ </tex-math></inline-formula>) and small bias (<inline-formula> <tex-math notation="LaTeX">$\text {mean}{ < }{3}\%$ </tex-math></inline-formula>). Both measurement systems identified similar aging, feedback, and stance type effects including (1) altered movement control when older adults performed tilting trials with either robotic or virtual feedback compared to without feedback, (2) two-fold greater wobble board oscillations in older vs. younger adults during steady standing, (3) no difference in board oscillations during steady standing in narrow vs. wide double support, and (4) greater wobble board oscillations for single compared to double support. These findings demonstrate the feasibility of implementing goal-directed robotic balance training with mobile tracking of balance performance in home environments.
Fishing Downstream: Does CSPAP Promotion During PETE Transfer to Teaching Practice by K–12 Physical Educators?

ABSTRACT Physical Education Teacher Education (PETE) training has the potential to influence graduates’ decisions as physical educators. Utilizing themes from Rogers’ Diffusion of Innovations and Lawson’s Occupational Socialization theories, we focused on graduates from a single PETE program which, beginning in 2007, began integrating content, expectations, and experiences relating to an expanded role of the physical educator such as in comprehensive school physical activity programs (CSPAPs). Purpose: The purpose of this study was to examine transfer in terms of university training leading to teaching practices in expanded physical activity programming. Method: An electronic questionnaire was sent to 335 graduates from May 2000 through May 2019. Sixty-seven graduates’ questionnaires were investigated looking at perceptions of CSPAP as an innovation, current expanded physical activity (PA) offerings, and memories of PETE. Additionally, 13 participants participated in a school visit and interview which acted as a fidelity check for self-reported levels of expanded PA programming reported in the questionnaire. Results: All 67 graduates included some amount of expanded PA programming. Positive correlations were found with perception of CSPAP as an innovation, for both year of graduation and memory of PETE programming, thus students exposed to CSPAP programming during PETE were implementing components at their schools at higher levels. Conclusion: There is positive potential for professional socialization to influence graduates’ practices. Perceptions of CSPAP as an innovation were positive and support the promotion of triability and starting small when PETE programs encourage expanded PA programming.
Functional and morphometric assessment of small-fibre damage in late-onset hereditary transthyretin amyloidosis with polyneuropathy: the controversial relation between small-fibre-related symptoms and diagnostic test findings

Abstract Introduction We aimed at investigating whether functional and morphometric tests assessing small-fibre damage, ie quantitative sensory testing, Sudoscan and skin biopsy, reliably reflect neuropathic pain and autonomic symptoms in patients with late-onset hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN). Methods In 30 patients with late-onset ATTRv-PN, we collected quantitative sensory testing, Sudoscan and skin biopsy with assessment of intraepidermal, piloerector muscle and sweat gland nerve fibre density. We then correlated these functional and morphometric parameters with neuropathic pain and autonomic symptoms as assessed with the Neuropathic Pain Symptom Inventory (NPSI) and Composite Autonomic Symptom Score-31 (COMPASS-31). Results 50% of patients showed small-fibre damage in the form of a pure small-fibre neuropathy, 47% in the context of a mixed fibre neuropathy with small and large fibre involvement. All patients complained of at least one autonomic symptom and 60% had neuropathic pain. Whereas quantitative sensory testing and Sudoscan parameters correlated with neuropathic pain and autonomic symptoms as assessed by NPSI and COMPASS-31, intraepidermal, piloerector muscle and sweat gland nerve fibre density quantification did not. Conclusions Our findings indicate that functional test parameters reliably reflect neuropathic pain and autonomic symptoms related to small-fibre damage. These findings might help to identify clinically useful biomarkers to assess patient follow-up.
TESTING FOR A UNIT ROOT IN A TIME SERIES WITH A LEVEL SHIFT AT UNKNOWN TIME

Unit root tests for time series with level shifts of general form are considered when the timing of the shift is unknown. It is proposed to estimate the nuisance parameters of the data generation process including the shift date in a first step and apply standard unit root tests to the residuals. The estimation of the nuisance parameters is done in such a way that the unit root tests on the residuals have the same limiting distributions as for the case of a known break date. Simulations are performed to investigate the small sample properties of the tests, and empirical examples are discussed to illustrate the procedure.
Assessment of deep learning pose estimates for sports collision tracking

ABSTRACT Injury assessment during sporting collisions requires estimation of the associated kinematics. While marker-based solutions are widely accepted as providing accurate and reliable measurements, setup times are lengthy and it is not always possible to outfit athletes with restrictive equipment in sporting situations. A new generation of markerless motion capture based on deep learning techniques holds promise for enabling measurement of movement in the wild. The aim of this work is to evaluate the performance of a popular deep learning model “out of the box” for human pose estimation, on a dataset of ten staged rugby tackle movements performed in a marker-based motion capture laboratory with a system of three high-speed video cameras. An analysis of the discrepancy between joint positions estimated by the marker-based and markerless systems shows that the deep learning approach performs acceptably well in most instances, although high errors exist during challenging intervals of heavy occlusion and self-occlusion. In total, 75.6% of joint position estimates are found to have a mean absolute error (MAE) of less than or equal to 25 , 17.8% with MAE between 25 and 50 and 6.7% with MAE greater than 50 . The mean per joint position error is 47 .
Leisure-time physical activity from adolescence to late middle age and its associations with the COVID-19 pandemic: A 45-year follow-up

ABSTRACT We aimed to investigate the association of self-reported leisure-time physical activity (LTPA) over a 45-years from adolescence to late middle age mediated by LTPA in early middle age. We also explored whether LTPA in adolescence and early middle age was associated with change in LTPA during the COVID-19 pandemic. We constructed a path model employing questionnaire data from three LTPA measurements (1976, 2001, 2021) including duplicated assessment for pre- and during COVID-19 in 2021. The direct and indirect associations between LTPA in adolescence, early middle and late middle age were investigated, as well as the impact of previous LTPA on change in late middle age LTPA due to the pandemic. The number of participants per assessment was: n = 2083; n = 1468 (71% of the original); n = 878 (42%) and n = 867 (42%), respectively. However, the number varied depending on the path examined. LTPA in adolescence was associated with LTPA in late middle age, although the association was not strong. LTPA decreased significantly during the pandemic. Earlier LTPA was associated with change in LTPA between before and during COVID-19 among males. This study is the first to demonstrate an association between adolescent and late middle age LTPA. However, the association across the 45-years was low.
Alcohol as a risk factor for mortality in liver transplant patients in Sweden

Abstract Objectives Liver transplantation (LT) is the only available cure for end-stage liver disease and one of the best treatment options for hepatocellular carcinomas (HCC). Patients with known alcohol-associated cirrhosis (AC) are routinely assessed for alcohol dependence or abuse before LT. Patients with other liver diseases than AC may consume alcohol both before and after LT. The aim of this study was to assess the effects of alcohol drinking before and after LT on patient and graft survival regardless of the etiology of liver disease. Materials and Methods Between April 2012 and December 2015, 200 LT-recipients were interviewed using the Lifetime Drinking History and the Addiction Severity Index questionnaire. Patients were categorized as having AC, n = 24, HCC and/or hepatitis C cirrhosis (HCV), n = 69 or other liver diseases, n = 107. Patients were monitored and interviewed by transplantation-independent staff for two years after LT with questions regarding their alcohol consumption. Patient and graft survival data were retrieved in October 2019. Results Patients with AC had an increased hazard ratio (HR) for death after LT (crude HR: 4.05, 95% CI: 1.07–15.33, p = 0.04) and for graft loss adjusted for age and gender (adjusted HR: 3.24, 95% CI 1.08–9.77, p = 0.04) compared to the other patients in the cohort. There was no significant effect of the volume of alcohol consumed before or after LT on graft loss or overall survival. Conclusion Patients transplanted for AC have a worse prognosis, but we found no correlation between alcohol consumed before or after LT and graft or patient survival.
A 3 × 109 M☉ Black Hole in the Quasar SDSS J1148+5251 at z = 6.41

We present near-infrared H- and K-band spectra of the z = 6.41 quasar SDSS J114816.64+525150.3. The spectrum reveals a broad Mg II λ2799 emission line with an FWHM of 6000 km s-1. From the peak wavelength of this emission line, we obtain a more accurate redshift than is possible from the published optical spectrum and determine a redshift of z = 6.41 ± 0.01. If the true peak of the Lyα emission is at the same redshift, then a large fraction of the flux blueward of the peak is absorbed. The equivalent width of the Mg II emission line is similar to that of lower redshift quasars, suggesting that the UV continuum is not dominated by a beamed component. Making basic assumptions about the line-emitting gas, we derive a mass estimate of 3 × 109 M☉ for the central black hole in this quasar. The very high luminosity of the quasar shows that it is accreting at the maximal allowable rate for a black hole of this mass, adopting the Eddington limit criterion.
Emergencies in obstetric anaesthesia: a narrative review

We conducted a narrative review in six areas of obstetric emergencies: category‐1 caesarean section; difficult and failed airway; massive obstetric haemorrhage; hypertensive crisis; emergencies related to neuraxial anaesthesia; and maternal cardiac arrest. These areas represent significant research published within the last five years, with emphasis on large multicentre randomised trials, national or international practice guidelines and recommendations from major professional societies. Key topics discussed: prevention and management of failed neuraxial technique; role of high‐flow nasal oxygenation and choice of neuromuscular drug in obstetric patients; prevention of accidental awareness during general anaesthesia; management of the difficult and failed obstetric airway; current perspectives on the use of tranexamic acid, fibrinogen concentrate and cell salvage; guidance on neuraxial placement in a thrombocytopenic obstetric patient; management of neuraxial drug errors, local anaesthetic systemic toxicity and unusually prolonged neuraxial block regression; and extracorporeal membrane oxygenation use in maternal cardiac arrest.
The Effect of Complete Prostate Examination of Radical Cystoprostatectomy Specimen on the Final Stage of Urothelial Carcinoma of the Urinary Bladder and the Detection of Prostate Cancer.

CONTEXT. — The prostate sampling methods for radical cystoprostatectomy (RCP) specimens may affect pathologic results. OBJECTIVE. — To investigate the impact on the tumor stage and clinicopathologic features according to the prostate sampling method for RCP specimens. DESIGN. — From 2016 to 2017, the prostate in RCP was minimally and conventionally embedded (group 1, n = 98). From 2017 to 2018, it was completely embedded (group 2, n = 102). RESULTS. — Group 2 was more likely to have prostatic ducts or acini involvement by urothelial carcinoma in situ component (27% versus 10%, P = .002) and prostate involvement (30% versus 13%, P = .003) than group 1. Although there were cases with prostatic stromal invasion in group 2 (14% versus 7%, P = .13), it was not statistically significant. In all, 6 cases were upstaged by subepithelial prostatic stromal invasion through intraurethral extension according to the 8th edition of the American Joint Committee on Cancer (AJCC) staging system. Tumor location and the presence of concurrent carcinoma in situ were strongly associated with prostate involvement of urothelial carcinoma. Prostatic adenocarcinoma (PA) was incidentally identified in 47 cases (23.5%). Incidental PA and clinically significant PA were more often identified in group 2 than group 1 (38% versus 8%, P < .01 and 15% versus 6%, P = .048, respectively). CONCLUSIONS. — A complete prostate examination in RCP specimens can be suggested, since the final pathologic stage can be changed through a thorough prostate examination especially in accord with the AJCC staging manual 8th edition. In addition, the complete prostate analysis could detect more incidental and clinically significant PA.
Comparison of hearing screening outcomes in newborns of gestational diabetic and non-diabetic mothers: a prospective, controlled study

Abstract Objectives To investigate whether Gestational diabetes mellitus (GDM) is related to presumptive hearing impairment in newborns. Study design The newborns were divided into two groups. The first group included the children of gestational diabetic pregnancies (DPs), and the second group, the children of non-gestational diabetic pregnancies (NDPs). Transient evoked otoacoustic emissions (TEOAE) and automated Auditory Brainstem Response (aABR) tests were applied as hearing screening tests. Results Twenty (40.8%) newborns in the DPs group and 5 (7.7%) newborns in the NDPs group failed the first hearing screening test (p = .001). The number of newborns with bilateral failed hearing screening tests was higher in the DPs group at the first screening (75% vs. 20%, p = .04). Fifteen (75.0%) of 20 newborns in the DPs group and 1 (20.0%) of 5 newborns in the NDPs group failed the second TEOAE hearing screening test (p = .04). Conclusion The possibility of presumptive hearing impairment is higher in the newborns of mothers with gestational diabetes compared to the newborns of non-diabetic mothers.
Crystal-Chemical Study by Xanes of Trioctahedral Micas

A crystal-chemical study of trioctahedral micas previously characterized by single-crystal XRD has been performed by XANES spectroscopy at the Si and Al K edges. XANES, being a local structural probe, can investigate distortion and modification of the tetrahedral sheet with increasing Fe for Mg substitution in the octahedral sheet. Comparison of XANES spectra allows determining the size of the tetrahedral site occupied by either Si or Al. The Si-O distance remains essentially unchanged whereas the Al-O distance appears to increase. The behavior may be interpreted as a tilt of the tetrahedra, initially rotated to match the ideal mica geometry, with increasing Fe substitution in the octahedral sheet.
Gaming motivations and gaming disorder symptoms: A systematic review and meta-analysis

Abstract Background and aims The present systematic review and meta-analysis aimed to synthesize the available literature on the relationship between gaming motivations and gaming disorder symptoms. Specifically, to (1) explore what gaming motivation questionnaires and classifications are used in studies on gaming disorder symptoms and (2) investigate the relationship between motivational factors and symptoms of gaming disorder. Method An electronic database search was conducted via EBSCO (MEDLINE and PsycINFO) and the Web of Science Core Collection. All studies using validated measurements on gaming disorder symptoms and gaming motivations and available correlation coefficients of the relationship between gaming disorder and gaming motivations were included. The meta-analyses were conducted using a random-effects model. Results In total, 49 studies (k = 58 independent sub-samples), including 51,440 participants, out of which 46 studies (k = 55 sub-samples, n = 49,192 participants) provided data for the meta-analysis. The synthesis identified fourteen different gaming motivation instruments, seven unique motivation models, and 26 motivational factors. The meta-analysis showed statistically significant associations between gaming disorder symptoms and 23 out of 26 motivational factors, with the majority of the pooled mean effect sizes ranging from small to moderate. Moreover, large heterogeneity was observed, and the calculated prediction intervals indicated substantial variation in effects across populations and settings. Motivations related to emotional escape were robustly associated with gaming disorder symptoms. Discussion and conclusions The present meta-analysis reinforces the importance of motivational factors in understanding problematic gaming behavior. The analysis showed significant heterogeneity in most outcomes, warranting further investigation. Registration detail PROSPERO (CRD42020220050).
Forward-adjoint coupling as a means of solving three-dimensional deep- penetration transport problems

The solution of a special type of deep penetration problem is obtained by coupling a deep-penetration forward calculation with a localized adjoint calculation. The system on which the calculation is performed consists of a target far removed from a radiation source. In the absence of the target, the system geometry is simple (i.e., one- or two-dimensional). The problem is to compute some effect of interest (e.g., reaction rate, flux, etc.) within the target. The problem solution consists of a source-centered calculation of the radiation field with the target absent, a targetcentered adjoint calculation on the system with the source absent, and a coupling of the above two calculations. The technique was applied to fissile and non-fissile targets located at various distances from and having various orientations with respect to a unit isotropic point fission neutron source in an infinite air medium. (3 tables) (auth)
Refined eigenvalue bounds on the Dirichlet fractional Laplacian

The purpose of this article is to establish new lower bounds for the sums of powers of eigenvalues of the Dirichlet fractional Laplacian operator (−Δ)α/2|Ω restricted to a bounded domain Ω ⊂ ℝd with d = 2, 1 ≤ α ≤ 2 and d ≥ 3, 0 < α ≤ 2. Our main result yields a sharper lower bound, in the sense of Weyl asymptotics, for the Berezin-Li-Yau type inequality improving the previous result [S. Yildirim Yolcu and T. Yolcu, Discrete Contin. Dyn. Syst. 35(5), 2209–2225 (2015)]. Furthermore, we give a result improving the bounds for analogous elliptic operators [Y. -C. Kim, e-print arXiv:1406.5407].
Global spread and evolutionary convergence of multidrug-resistant and hypervirulent Klebsiella pneumoniae high-risk clones

ABSTRACT For people living in developed countries life span is growing at a faster pace than ever. One of the main reasons for such success is attributable to the introduction and extensive use in the clinical practice of antibiotics over the course of the last seven decades. In hospital settings, Klebsiella pneumoniae represents a well-known and commonly described opportunistic pathogen, typically characterized by resistance to several antibiotic classes. On the other hand, the broad wedge of population living in Low and/or Middle Income Countries is increasing rapidly, allowing the spread of several commensal bacteria which are transmitted via human contact. Community transmission has been the original milieu of K. pneumoniae isolates characterized by an outstanding virulence (hypervirulent). These two characteristics, also defined as “pathotypes”, originally emerged as different pathways in the evolutionary history of K. pneumoniae. For a long time, the Sequence Type (ST), which is defined by the combination of alleles of the 7 housekeeping genes of the Multi-Locus Sequence Typing, has been a reliable marker of the pathotype: multidrug-resistant clones (e.g. ST258, ST147, ST101) in the Western world and hypervirulent clones (e.g. ST23, ST65, ST86) in the Eastern. Currently, the boundaries separating the two pathotypes are fading away due to several factors, and we are witnessing a worrisome convergence in certain high-risk clones. Here we review the evidence available on confluence of multidrug-resistance and hypervirulence in specific K. pneumoniae clones.
LEMON: LanguagE ModeL for Negative Sampling of Knowledge Graph Embeddings

Knowledge Graph Embedding models have become an important area of machine learning.Those models provide a latent representation of entities and relations in a knowledge graph which can then be used in downstream machine learning tasks such as link prediction. The learning process of such models can be performed by contrasting positive and negative triples. While all triples of a KG are considered positive, negative triples are usually not readily available. Therefore, the choice of the sampling method to obtain the negative triples play a crucial role in the performance and effectiveness of Knowledge Graph Embedding models. Most of the current methods fetch negative samples from a random distribution of entities in the underlying Knowledge Graph which also often includes meaningless triples. Other known methods use adversarial techniques or generative neural networks which consequently reduce the efficiency of the process. In this paper, we propose an approach for generating informative negative samples considering available complementary knowledge about entities. Particularly, Pre-trained Language Models are used to form neighborhood clusters by utilizing the distances between entities to obtain representations of symbolic entities via their textual information. Our comprehensive evaluations demonstrate the effectiveness of the proposed approach on benchmark Knowledge Graphs with textual information for the link prediction task.