Miracle-dz/UniFAR-FTUs huggingface dataset:
Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson’s Disease Model by Alleviating Mitochondrial Dysfunction

Parkinson’s disease is the second most common neurodegenerative disease. Unfortunately, there is still no definitive disease-modifying therapy. In our work, the antiparkinsonian potential of trans-epoxide (1S,2S,3R,4S,6R)-1-methyl-4-(prop-1-en-2-yl)-7-oxabicyclo [4.1. 0]heptan-2,3-diol (E-diol) was analyzed in a rotenone-induced neurotoxicity model using in vitro, in vivo and ex vivo approaches. It was conducted as part of the study of the mitoprotective properties of the compound. E-diol has been shown to have cytoprotective properties in the SH-SY5Y cell line exposed to rotenone, which is associated with its ability to prevent the loss of mitochondrial membrane potential and restore the oxygen consumption rate after inhibition of the complex I function. Under the conditions of rotenone modeling of Parkinson’s disease in vivo, treatment with E-diol led to the leveling of both motor and non-motor disorders. The post-mortem analysis of brain samples from these animals demonstrated the ability of E-diol to prevent the loss of dopaminergic neurons. Moreover, that substance restored functioning of the mitochondrial respiratory chain complexes and significantly reduced the production of reactive oxygen species, preventing oxidative damage. Thus, E-diol can be considered as a new potential agent for the treatment of Parkinson’s disease.
Tribological Behavior of TiO2 PEEK Composite and Stainless Steel for Pediatric Crowns

Dental decay still presents a major health problem among children. Its treatment usually requires the use of stainless steel crowns. This study compares the wear behavior of 316 L stainless steel and polyetheretherketone (PEEK) composite under identical test conditions. The wear tests were conducted in a reciprocating ball-on-plate tribometer (Plint TE67/R) using alumina balls as a counterface and artificial saliva as a lubricant at 37 °C to faithfully mimic oral conditions. The coefficient of friction (COF) and specific wear rate (k) values were determined and SEM/EDS examinations were performed to identify the predominant wear mechanisms. Results showed that PEEK exhibited a significantly lower coefficient of friction (COF = 0.094 ± 0.004) and thus lower wear volume (ΔV = 0.0078 ± 0.0125 mm3) and higher wear resistance, with an average value of specific wear rate of k = 9.07 × 10−6 mm3N−1m−1 when compared to stainless steel (COF = 0.32 ± 0.03, ΔV = 0.0125 ± 0.0029 mm3, k = 1.45 × 10−5 mm3N−1m−1). PEEK was revealed to be a potential material for use in pediatric crowns due to its high wear resistance while overcoming the disadvantages associated with steel at both an aesthetic and biological level.
Constrained admission control to a queueing system

We consider an exponential queue with arrival and service rates depending on the number of jobs present in the queue. The queueing system is controlled by restricting arrivals. Typically, a good policy should provide a proper balance between throughput and congestion. A mathematical model for computing such a policy is a Markov decision chain with rewards and a constrained cost function. We give general conditions on the reward and cost function which guarantee the existence of an optimal threshold or thinning policy. An efficient algorithm for computing an optimal policy is constructed.
Generation of Subharmonics of Order One‐Half by Bubbles in a Sound Field

Under proper conditions, bubbles driven by a sound field will pulsate periodically with a frequency equal to one‐half the frequency of the sound field. This frequency component is the subharmonic of order one‐half and is generated when the acoustic‐pressure amplitude exceeds a threshold value. The threshold for subharmonic generation is calculated by means of a theory that relates the presence of the subharmonic to properties of Hill's equation. It is found that, for a given bubble, the threshold is a function of the driving frequency and is a minimum when the driving frequency is approximately twice the linear resonance frequency of the bubble. In addition, solutions of a set of nonlinear equations for the motion of the bubble wall, obtained on a computer, illustrate the growth of subharmonics and are used to determine the steady‐state amplitude and phase of the subharmonic for a sequence of values of various parameters.
RECONSTRUCTION ALGORITHMS IN IRREGULAR SAMPLING

A constructive solution of the irregular sampling problem for band- limited functions is given. We show how a band-limited function can be com- pletely reconstructed from any random sampling set whose density is higher than the Nyquist rate, and give precise estimates for the speed of convergence of this iteration method. Variations of this algorithm allow for irregular sampling with derivatives, reconstruction of band-limited functions from local averages, and irregular sampling of multivariate band-limited functions. In the irregular sampling problem one is asked whether and how a band- limited function / can be completely reconstructed from its irregularly sam- pled values f(xi). This has many applications in signal and image processing, seismology, meteorology, medical imaging, etc. Finding constructive solutions of this problem has received considerable attention among mathematicians and engineers. The mathematical literature provides several uniqueness results (1, 2, 17, 18, 19). It is now part of the folklore that for stable sampling the sampling rate must be at least the Nyquist rate (18). These results, as deep as they are, have had little impact for the applied sciences, because they were not constructive. If the sampling set is just a perturbation of the regular oversampling, then a reconstruction method has been obtained in a seminal paper by Duffin and Schaeffer (6) (see also (29)): if for some L > 0, a > 0, and o > 0 the sampling points xk , k e Z , satisfy (a) \xk - ok\ a, k ^ I, then the norm equivalence A iR \f(x)\2dx ) with w < n/o. This norm equivalence implies that it is possible to reconstruct / through an iterative procedure, the so-called frame method. Most of the later work on constructive methods consists of variations of this method (3, 21, 22, 26). The above conditions on the sampling set exclude random irregular sampling sets, e.g., sets with regions of higher sampling density. A partial, but undesirable remedy, to handle highly irregular sampling sets, would be to force the above conditions by throwing away information on part of the points and accept a very slow convergence of the iteration.
Consistent multilabel ranking through univariate loss minimization

We consider the problem of rank loss minimization in the setting of multilabel classification, which is usually tackled by means of convex surrogate losses defined on pairs of labels. Very recently, this approach was put into question by a negative result showing that commonly used pairwise surrogate losses, such as exponential and logistic losses, are inconsistent. In this paper, we show a positive result which is arguably surprising in light of the previous one: the simpler univariate variants of exponential and logistic surrogates (i.e., defined on single labels) are consistent for rank loss minimization. Instead of directly proving convergence, we give a much stronger result by deriving regret bounds and convergence rates. The proposed losses suggest efficient and scalable algorithms, which are tested experimentally.
Cultivation protocol using a coir-based substrate modulates the concentration of bioactive compounds and the antioxidant activity of Passiflora alata Curtis seedlings

ABSTRACT The use of coconut coir dust is a low-cost cultivation practice. Thus, this study aimed to determine the effect of coconut coir dust proportion on foliar secondary metabolite biosynthesis and growth of Passiflora alata Curtis (sweet passion fruit). This Passiflora species possess pharmaceutical relevance and the use of organic-based substrates may promote the production of bioactive compounds in the phytomass. An experiment in a greenhouse was set up with three proportions of coir dust mixed with a commercial substrate for seedlings (CSS) (peat-based) (S1= 1:1:1, CSS: sand: coconut coir dust; S2= 1.5:1.5:1, CSS: sand: coconut coir dust and S3= 1:1, sand: CSS) in seven replicates. After 68 days, growth parameters were measured (height, leaf area, number of leaves, stem diameter, and dry matter), and the harvested leaves were used to prepare ethanolic extracts. The total antioxidant activity and production of phenolics, flavonoids, proanthocyanidins, and saponins were assessed. Unexpectedly, the coir dust supply did not favor the growth and production of secondary metabolites, as the best results were observed in plants grown in S3. Moreover, S3 is efficient in optimizing the growth, metabolite content, and antioxidant capacity of P. alata foliar extracts dispensing coir dust supplementation in the substrate. Therefore, adding coir to CSS is not recommended to enhance the production of secondary metabolites and the growth of P. alata seedlings.
Correlated Iron 60, Nickel 62, and Zirconium 96 in Refractory Inclusions and the Origin of the Solar System

We report precise nickel isotopic compositions, measured with high-resolution MC-ICPMS, for calcium-aluminum-rich inclusions (CAIs) considered to be the earliest objects formed in the solar system. The CAIs display correlated anomalies of 60Ni and 62Ni, possibly coupled with effects on 96Zr. This is not predicted from stellar production models unless the 60Ni results from the decay of 60Fe. The effects show the signature of neutron-burst nucleosynthesis in a massive star. Such a neutron burst is plausibly responsible for the abundance of many of the short-lived radioactivities present in the early solar system; therefore, at least some of the nucleosynthetic heterogeneity previously reported from CAIs, leached carbonaceous chondrites, and presolar grains is likely to have been generated by dust injection from a supernova at a time close to the beginning of the solar system, which is consistent with a trigger for solar nebula collapse, or generated directly by dust injection into the protoplanetary disk.
National Knowledge-Driven Management of Obstructive Sleep Apnea—The Swedish Approach

Introduction: This paper describes the development of “Swedish Guidelines for OSA treatment” and the underlying managed care process. The Apnea Hypopnea Index (AHI) is traditionally used as a single parameter for obstructive sleep apnea (OSA) severity classification, although poorly associated with symptomatology and outcome. We instead implement a novel matrix for shared treatment decisions based on available evidence. Methods: A national expert group including medical and dental specialists, nurses, and patient representatives developed the knowledge-driven management model. A Delphi round was performed amongst experts from all Swedish regions (N = 24). Evidence reflecting treatment effects was extracted from systematic reviews, meta-analyses, and randomized clinical trials. Results: The treatment decision in the process includes a matrix with five categories from a “very weak”” to “very strong” indication to treat, and it includes factors with potential influence on outcome, including (A) OSA-related symptoms, (B) cardiometabolic comorbidities, (C) frequency of respiratory events, and (D) age. OSA-related symptoms indicate a strong incitement to treat, whereas the absence of symptoms, age above 65 years, and no or well-controlled comorbidities indicate a weak treatment indication, irrespective of AHI. Conclusions: The novel treatment matrix is based on the effects of treatments rather than the actual frequency of respiratory events during sleep. A nationwide implementation of this matrix is ongoing, and the outcome is monitored in a prospective evaluation by means of the Swedish Sleep Apnea Registry (SESAR).
Finite Sample Properties of Tests of the Epstein-Zin Asset Pricing Model

This paper investigates the small sample properties of Hansen and Singleton (1982)-type GMM tests of asset pricing restrictions implied by Epstein and Zin (1989) preferences. The Monte Carlo results suggest that tests of the Epstein and Zin (1989) asset pricing model often have little size-adjusted power to reject asset pricing restrictions implied by simpler, time and state separable expected utility preferences, even when parameters are chosen to make the difference between the relative risk aversion parameter and the reciprocal of the intertemporal substitution parameter large. There is evidence that a Wald test has greater power than other tests and that use of Hansen, Heaton and Yaron's (1996) continuous-updating GMM estimator improves the power of the tests.
Influence of Bulk Nanobubbles Generated by Acoustic Cavitation on Powder Microstructure and Rehydration Characteristics of Spray-Dried Milk Protein Concentrate Powders

Bulk nanobubbles (BNBs) have widespread applications in various fields of science due to numerous peculiar characteristics. Despite significant applications, only limited investigations are available on the application of BNBs in food processing. In the present study, a continuous acoustic cavitation technique was used to generate bulk nanobubbles (BNBs). The aim of this study was to evaluate the influence of BNB incorporation on the processability and spray drying of milk protein concentrate (MPC) dispersions. MPC powders were reconstituted to the desired total solids and incorporated with BNBs using acoustic cavitation as per the experimental design. The control MPC (C-MPC) and BNB-incorporated MPC (BNB-MPC) dispersions were analyzed for rheological, functional, and microstructural properties. The viscosity significantly decreased (p < 0.05) at all the amplitudes studied. The microscopic observations of BNB-MPC dispersions showed less aggregated microstructures and greater structural differences compared with C-MPC dispersions, therefore lowering the viscosity. The viscosity of BNB incorporated (90% amplitude) MPC dispersions at 19% total solids at a shear rate of 100 s−1 significantly decreased to 15.43 mPa·s (C-MPC: 201 mPa·s), a net decrease in viscosity by ~90% with the BNB treatment. The control and BNB incorporated MPC dispersions were spray-dried, and the resultant powders were characterized in terms of powder microstructure and rehydration characteristics. Focused beam reflectance measurement of the BNB-MPC powders indicated higher counts of fine particles (<10 μm) during dissolution, signifying that BNB-MPC powders exhibited better rehydration properties than the C-MPC powders. The enhanced powder rehydration with the BNB incorporation was attributed to the powder microstructure. Overall, reducing the viscosity of feed by BNB incorporation can enhance the performance of the evaporator. This study, therefore, recommends the possibility of using BNB treatment for more efficient drying while improving the functional properties of the resultant MPC powders.
Pain Perceptions, Suffering and Pain Behaviours of Professional and Pre-Professional Dancers towards Pain and Injury: A Qualitative Review

Limited data exist that describe the experiences of pain and injury in dancers. The purpose of the current study was to understand pain perceptions, suffering and pain behaviours associated with pre-professional and professional dancers and to consider the psychosocial factors that influence suffering, behaviour and perceptions of pain. A thematic synthesis review was undertaken in three stages: (1) A systematic search using pre-defined search terms was conducted until 17 November 2022. Qualitative studies were included if they captured dancers’ perceptions, experiences, or the behaviour of dancers towards pain and injury. (2) Quality appraisal and certainty assessments was performed. (3) A five-phase synthesis generated themes that included a certainty assessment score. Twelve studies with 290 dancers met the inclusion criteria. The aggregated mean age was identified as 28.5 years. No studies were excluded following the quality appraisal stage. Nine studies included professional ballet dancers. Three themes were developed: (1) developing positive and adapted perceptions and behaviours towards pain, (2) the impact and danger of embracing pain and the risk of injury and (3) factors that influenced the response to injury and the ability to perform. This review has highlighted the experiences of pre-professional and professional dancers towards pain and injury. Practical implications for healthcare professionals, employers, choreographers and dancers are provided. Further research is required given the limited evidence base.
Nonlinear robust control and minimax team problems

The problem of robust stabilization of a linear system leads to the classical H∞ control problem. The same analysis applied to a nonlinear system leads to the problem of insuring via output feedback that a nonlinear operator be Lipshitz continuous, with a prescribed Lipshitz modulus. We show that, in the same way as the H∞ control problem is equivalent to a minimax control problem, the Lipshitz modulus control problem can be approached via a minimax team decision problem. This motivates us to re-visit a class of so-called “static” team decision problems for nonlinear dynamical control systems. Because of the “static” character, signaling plays no role in that case, which is important for the equivalence with the Lipshitz modulus control problem. We show that under some conditions, a certainty equivalence principle applies that yields a practical solution to the team problem at hand. To reach that conclusion we must first investigate a “partial team” problem where one of the team members has all the information.
Comparison of Efficacy and Safety of Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure With Reduced Ejection Fraction: A Meta-Analysis

The present meta-analysis was conducted to compare the safety and efficacy of angiontensin receptor neprilysin inhibitor (ARNI) with angiotensin receptor blockers (ARBs) and angiotensin-converting-enzyme inhibitors (ACEi) in patients with heart failure with reduced ejection fraction (HFrEF). This meta-analysis was conducted and reported in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. Two authors carried out a scientific literature search on online databases, including EMBASE, PubMed, and the Cochrane Library. The following keywords or corresponding Medical Subject Headings (MeSH) were used for the search of relevant articles: “heart failure with reduced ejection fraction,” “angiotensin receptor-neprilysin inhibitor,” “Angiotensin receptor blockers,” and “clinical outcomes. ” Outcomes assessed in the present meta-analysis included changes in ejection fraction (EF) from baseline in percentage. Other outcomes assessed in the present meta-analysis included all-cause mortality, cardiovascular death, and hospitalization due to heart failure. Adverse events assessed in the present meta-analysis included hypokalemia, acute kidney injury, and hypotension. Total 10 studies were included. This meta-analysis showed that treatment with ARNI was associated with a significantly lower risk of all-cause mortality and cardiovascular death compared to control groups. There was no significant difference between the two groups in terms of change of EF from baseline or hospitalization related to heart failure. However, the risk of hypotension was significantly higher in patients receiving ARNI. The study findings support the use of ARNI as first-line therapy for heart failure with reduced ejection fraction. Further studies are required to determine the optimal use of ARNI in heart failure management and to investigate the mechanisms underlying the increased risk of hypotension.
Factors Associated with Neuroimaging Abnormalities in Children with Afebrile Seizure: A Retrospective Multicenter Study

Introduction Neuroimaging is recommended for patients with seizures to identify intracranial pathology. However, emergency physicians should consider the risks and benefits of neuroimaging in pediatric patients because of their need for sedation and greater sensitivity to radiation than adults. The purpose of this study was to identify associated factors of neuroimaging abnormalities in pediatric patients experiencing their first afebrile seizure. Methods This was a retrospective, multicenter study that included children who presented to the emergency departments (ED) of three hospitals due to afebrile seizures between January 2018–December 2020. We excluded children with a history of seizure or acute trauma and those with incomplete medical records. A single protocol was followed in the three EDs for all pediatric patients experiencing their first afebrile seizure. We performed multivariable logistic regression analysis to identify factors associated with neuroimaging abnormalities. Results In total, 323 pediatric patients fulfilled the study criteria, and neuroimaging abnormalities were observed in 95 patients (29.4%). Multivariable logistic regression analysis showed that Todd’s paralysis (odds ratio [OR] 3.72, 95% confidence interval [CI] 1.03–13.36; P=0.04), absence of poor oral intake (POI) (OR 0.21, 95% CI 0.05–0.98; P=0.05), lactic acidosis (OR 1.16, 95% CI 1.04–1.30; P=0.01), and higher level of bilirubin (OR 3.33, 95% CI 1.11–9.95; P=0.03) were significantly associated with neuroimaging abnormalities. Based on these results, we constructed a nomogram to predict the probability of brain imaging abnormalities. Conclusion Todd’s paralysis, absence of POI, and higher levels of lactic acid and bilirubin were associated factors of neuroimaging abnormalities in pediatric patients with afebrile seizure.
Tuning Alkaline Anion Exchange Membranes through Crosslinking: A Review of Synthetic Strategies and Property Relationships

Alkaline anion exchange membranes (AAEMs) are an enabling component for next-generation electrochemical devices, including alkaline fuel cells, water and CO2 electrolyzers, and flow batteries. While commercial systems, notably fuel cells, have traditionally relied on proton-exchange membranes, hydroxide-ion conducting AAEMs hold promise as a method to reduce cost-per-device by enabling the use of non-platinum group electrodes and cell components. AAEMs have undergone significant material development over the past two decades; however, challenges remain in the areas of durability, water management, high temperature performance, and selectivity. In this review, we survey crosslinking as a tool capable of tuning AAEM properties. While crosslinking implementations vary, they generally result in reduced water uptake and increased transport selectivity and alkaline stability. We survey synthetic methodologies for incorporating crosslinks during AAEM fabrication and highlight necessary precautions for each approach.