Miracle-dz/UniFAR-FTUs huggingface dataset:
The Hepatoprotective Effect of Carrot (Daucus Carota L.) as Antioxidant on Intoxicated rats with Ccl4

ABSTRACT The effect of feeding dry powder of carrot at three graded concentrations (5,10,20 %) mixed with the basal diet to carbon tetrachloride (Ccl4) intoxicated male rats for 4 weeks was studied. Intoxication of rats was done by s/c injection of Ccl4 (1 ml/kg) in the first (treatment group) and the last (prophylaxis ) two days of feeding period, as a single dose per day. Results of this study revealed that prophylaxis is more powerful than treatment groups. Both groups significantly increased feed intake, body weight gain percent and feed efficiency ratio. Biochemical analyses cleared that carrot supplementation to diet significantly lowered serum total cholesterol, triglycerides and LDL cholesterol, but increased HDL cholesterol. Serum liver enzymes( AST and ALT) as well as concentrations of urea nitrogen, uric acid and creatinine decreased in rats fed carrot supplemented diet . Histopathological examinations of liver and kidneys of these rats showed a decrease or amelioration of pathological lesions and damages caused by Ccl4 intoxicated rats.
Could Education Increase the Economic Growth of Mexico?

BSTRACT This paper studies the role of education on the economic growth of Mexico. The Uzawa-Lucas Model is used to study the contribution of human capital on growth, while the specific role of education is accounted with a Vector Error Correction (VEC) Model. The main finding of this paper is that an increase of one percent in human capital implies an increase of 1.59 percent on Mexican Gross Domestic Product (GDP). And given the role of education on human capital, an increase of one percent in years of schooling causes an increase in the long run GDP growth rate of 2.19
Give a Gist: The Impact of Thumbnails on the View-Through of Videos

As more businesses become aware of the advantages of video marketing, competition in online video platforms is becoming fierce. It is becoming more challenging to stand out from the crowd of video content. Industry experts and anecdotal evidence have highlighted the importance of thumbnails for the view-through of videos. Thumbnails are usually the first thing that potential viewers see when they browse through an online video platform. While browsing through the platform, they decide which videos to watch based on the information and impression they obtain from thumbnails. Thumbnails, therefore, need to be able to tell potential viewers what the video is about (i.e., informative) and at the same time need to grab potential viewers’ attention (i.e., visually appealing). Using 3,745 marketing videos posted by 38 top brands across 4 industries – automobile, beverage, restaurant, and toy – on YouTube, we investigate the relationship of the view-through of videos both with the informativeness of thumbnails, measured using element complexity that refers to the number of design elements – product, person, and text – used in thumbnails, and with the aesthetic characteristics of thumbnails such as celebrity endorsement, object complexity, color complexity, brightness, and image quality, while controlling for the social capital of the brands that post the videos as well as the characteristics of the videos themselves such as length, age, and viewer reviews. We construct our variables by extracting descriptive and aesthetic features from thumbnails using machine learning techniques. Our measures, therefore, are scalable and not subjective. Our study contributes to the literature on information systems and marketing by enhancing the understanding of the role of visual complexity in the context of video content marketing. Finally, our results provide important and detailed guidelines for video marketing managers on how to optimize thumbnails to grab potential viewers’ attention and yield more video views.
Structural intergrowth of merlinoite/phillipsite and its temperature-dependent dehydration behaviour: a single-crystal X-ray study

Abstract Supposed ‘merlinoite’ crystals from Monte Somma, Vesuvius (Italy) and Fosso Attici, north of Rome (Italy) represent highly twinned coherent intergrowths between merlinoite and phillipsite on a submicroscopic level. The MER (Immm, a ≈ 14.1, b ≈ 14.2, c ≈ 9.9 Å) and PHI (P21/m, a ≈ 9.9, b ≈ 14.3, c ≈ 8.7 Å, β = 124.8°) frameworks of similar composition are assembled from identical tetrahedral units, though with a different connectivity. Coherent intergrowth and twinning of the two frameworks lead to P42/mnm pseudosymmetry, which is diagnostic of the intergrowth. Under ambient conditions merlinoite has Immm symmetry or I4/mmm if twinned. A low-symmetry model of space group P121/m1 (a ≈14.2, b ≈ 14.2, c ≈ 10 Å, β = 90°) allows structure refinement and quantification of the two frameworks. Upon in situ dehydration to 250°C the evolution of the unit-cell volume of the Monte Somma merlinoite/phillipsite intergrowth displays an intermediate trend between previously studied pure merlinoite from the Khibiny massif (Russia) and Ba-rich phillipsite. The Monte Somma crystal studied by temperature-dependent single-crystal X-ray diffraction methods also contained a subordinate chabazite inclusion with no coherent structural relationship to the merlinoite/phillipsite framework. Thus, the modification of the chabazite framework on dehydration could also be studied.
Linking microbial genomes with their potential to degrade terrestrial organic matter in the Amazon River

Rivers connect the carbon cycle in land with that in aquatic ecosystems by transporting and transforming terrestrial organic matter (TeOM). The Amazon River receives huge loads of TeOM from the surrounding rainforest, promoting a substantial microbial heterotrophic activity and consequently, CO2 outgassing. In the Amazon River, microbes degrade up to 55% of the lignin present in the TeOM. Yet, the main microbial genomes involved in TeOM degradation were not known. Here, we characterize 51 population genomes (PGs) representing some of the most abundant microbes in the Amazon River deriving from 106 metagenomes. The 51 reconstructed PGs are among the most abundant microbes in the Amazon River, and 53% of them are not able to degrade TeOM. Among the PGs capable of degrading TeOM, 20% were exclusively cellulolytic, while the others could also oxidize lignin. The transport and consumption of lignin oxidation byproducts seemed to be decoupled from the oxidation process, being apparently performed by different groups of microorganisms. Altogether, based on our findings, we suggest a new priming effect model that explains the quick turnover of TeOM as a product of the microbial consumption of lignin-derived aromatic compounds produced by lignin oxidation, reducing the inhibition of cellulose degradation and ensuring structural carbon and energy for cell growth. By connecting the genomic features of abundant microbes in the Amazon River with the degradation of recalcitrant TeOM, we contribute to increase our understanding of the rapid consumption of recalcitrant compounds in this ecosystem.
Improving physical activity in ‘Health Volunteers’: A randomized controlled trial

Background Health volunteers are women who have humanistic cooperation with healthcare centers to prevent diseases. Health volunteers play an important role in the community. Thus if educated, they could be of great help to health care systems. Since physical inactivity and sedentary lifestyles increase the risk of all cause mortality, the aim of this study was to educate health volunteers on physical activity (PA) applying the theory of planned behavior (TPB). Methods This was a randomized controlled trial of an educational intervention to improve physical activity among health volunteers in Shushtar (a southern city), Iran in 2016. A sample of female health volunteers was entered into the study and randomly was assigned to the intervention and the control groups. The intervention included three educational sessions and a walking program. A questionnaire containing items on TPB constructs including: attitude, subjective norms, perceived behavioral control, intention and behavior constructs, the international physical activity questionnaire, and the physiological cost index (PCI- an objective measure of PA) were used to collect data at baseline and 6 months follow-up assessments. Then the data were compared within and between groups using t-test and paried test. Results In all 110 ‘Health Volunteers’ (55 per each group) were entered into the study. The mean age of participants was 35.65 ± 10.25 years. The results obtained from analysis showed that educational program improved attitude towards PA, perceived behavioral control, intention, behavior and PCI among the intervention group (P < 0.001). However, no significant changes occurred in the control group in terms of the study variables (P > 0.05). Additionally, comparison of score changes between two groups showed significant differences for all variables except for subjective norms and physical activity behavior (minute per day) group (P > 0.05). Conclusion The TPB-directed educational program improved physical activity and physiological cost index. The study framework might be used as a practical template for interventions aimed at improving physical activity among women.
Neuroinflammation and Disrupted Synaptic Plasticity, the Main Pathological Processes in Multiple Sclerosis and Obsessive-Compulsive Disorder: An Enrichment Analysis

Background: Multiple sclerosis (MS) is an autoimmune, inflammatory demyelinating, and disabling disorder of the central nervous system (CNS) with various clinical symptoms. Approximately 30% of the patients experience a variety of psychiatric problems during their disease course. Obsessive-compulsive disorder (OCD) is correlated with MS, but little is known about common molecular mechanisms of two diseases. Methods: In this study, after a comprehensive review of the existing literature, we collected almost all the genes involved in MS and OCD, and then analyzed the common genes between MS and OCD. Next, the connections and functional interactions between these three gene sets were investigated in the STRING database and analyzed in 3 separate networks by Cytoscape software. Eventually, after a multi-part enrichment analysis, we found the main molecular and cellular pathways, biological processes, brain areas, and, more importantly, cells/tissue related to the shared genes between MS and OCD. Results: Three genes of brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNFα), and neurexin-1 (NRXN1) are the major genes that were common between MS and OCD. Also, the deficit in synaptogenesis and neurotransmitter release in the nervous system are the most common complications of MS and OCD. Signaling receptor activity and estrogen receptor activity are the most important signaling pathways that are disturbed. Moreover, the presynaptic membrane, membrane raft, and growth cone are the main microenvironments that are affected in MS and OCD.Conclusions: In addition to an enrichment analysis that showed physical and functional interactions of genes related to MS and OCD, we demonstrated and predicted some new genes and microRNAs that can be promising biomarkers/targets for future experimental studies. Also, our finding indicated that neuroinflammation and synaptic plasticity are two significant pathological processes that are affected in MS and OCD.
Mono- and bis-dipicolinic acid heterocyclic derivatives – thiosemicarbazides, triazoles, oxadiazoles and thiazolidinones as antifungal and antioxidant agents

Abstract A series of dipicolinic acid derivatives was synthesized and investigated for antimicrobial and antioxidant activity. Mono and bis derivatives of ethyl dipicolinate were utilized as starting materials for synthesis of mono- and bis-hydrazides. Thiosemicarbazides were obtained by reaction of hydrazides with isothiocyanates and cyclized into triazoles, thiadiazoles, oxadiazoles and thiazolidinones. Some of these products, especially those incorporating a thiazolidinone moiety in their structure, are excellent antioxidants, DPPH scavengers and antifungal agents.
Factors Affecting Lactation Performance of Deoni Cattle

The research was conducted on 78 lactation records of 78 Deoni cows over three years to analyze the effect of non-genetic factors on lactation performance traits. Data of lactation records were analyzed to determine the effect of age, parity, a period of calving and season of calving on lactation traits, viz., lactation milk yield (LMY), peak milk yield (PMY), lactation length (LL) and persistency of lactation. The findings revealed that age group and parity had a significant (p ≤0.05) effect on lactation milk yield, but not the period of calving and season of calving. Further, only the parity had a significant (P≤0.05) effect on peak milk yield of Deoni cattle but not the age group, period of calving, and season of calving. The other two traits, namely lactation length, and persistence was not influenced significantly by any the non-genetic factors evaluated in Deoni cattle.
Stroke in Pregnancy and Perinatal Period

Introduction Stroke is a rare illness in pregnancy; nevertheless, it is one of the main causes of morbidity in young women of childbearing age. During pregnancy, a woman's body undergoes a number of pathophysiological changes that promote thrombus formation and increase the risk of stroke in comparison to women of the same age who are not pregnant. At that time, estrogens increase renin activity leading to increased sodium and water retention; heart rate goes up by 30-50%; cardiac output and arrhythmia index increase, venous capacity raises; venous return decreases; the vessel walls undergo remodeling; and the amount of elastin and collagen fibers decrease. The coagulation system presents a natural predominance of coagulation processes over fibrinolysis [1,2]. Factors increasing the risk of stroke include: the age of the pregnant woman (over 35), hypertension, obesity, smoking, systemic lupus, migraine with aura, diabetes, thrombophilia, pre-eclampsia and eclampsia, prolonged delivery, pregnancy intoxication, infection after delivery [2]. A meta analysis of Swartz et al. [3] covering the period from 1990 to 2017 showed that the prevalence of all strokes in pregnancy was 30.00 per 100,000 pregnant women (with a 95% confidence interval; 18.8-47); for ischemic strokes 19.9 (10.736.9); for hemorrhagic strokes 12.20 (6.7-2.2); and for strokes after delivery 14.7 (8.3-26.1). Ischemic and haemorrhagic strokes are most commonly observed in the last trimester of pregnancy and in the postpartum period [4].
A Cross-sectional Study on Zoonotic and Reverse Zoonotic Transmission of Tuberculosis in Central Ethiopia

Background: The zoonotic transmission of tuberculosis (TB) from cattle to humans has long been recognized while its reverse zoonotic transmission from humans to animals has recently been reported. The socioeconomic situations of the rural communities of Ethiopia are conducive for the zoonotic and reverse zoonotic transmission of TB between cattle and human. The objective of this study was to investigate the zoonotic and reverse zoonotic transmission TB between humans and cattle central Ethiopia.Methods: To achieve this objective a cross-sectional study was conducted on 1896 cattle slaughtered in two abattoirs and 392 TB suspicious human subjects visiting health institutions for treatment. Post mortem examination, mycobacteriological culture, and spoligotyping were used for the study. In addition, the Spoligotype International Types and VNTR (variable number of DNA tandem repeats) International Types (SITVIT2) database and the online “Run TB-Lineage” were used to identify SIT and lineages of the human and cattle isolates.Results: Gross TB lesion was detected in 4.2% (80/1896) the slaughtered cattle and predominantly (52.5%) found in the thoracic cavity. But culture positivity was only 26.3% (21/80) in suspicious lesions. Of the 21 cattle isolates, 12 (57.2%) were M. bovis while the remaining nine (42.8%) were M. tuberculosis. SIT50, SIT118 and SIT1318 were isolated from both humans and cattle. Similar to the low culture yield in cattle tissues, only 22% (86/392) the sputa from TB suspicious humans were culture positive. These 86 human isolates were classified into 81 M. tuberculosis, three M. africanum and two M. bovis by spoligotyping. The two human M. bovis isolates had the pattern of SB1443, which was not isolated from cattle in this study.Conclusion: The zoonotic and reverse zoonotic transmissions of TB were confirmed in Ethiopia by the isolation of two M. bovis from human and isolation of nine M. tuberculosis from cattle, which suggested higher role of M. tuberculosis in cattle compared to the role of M. bovis in humans.
Interior Optimization Methods with Electronics Applications

The nonlinear multiobjective optimization problem constitutes a difficult task to find/determine a global minimum, approximated-global minimum, or a convenient local minimum whith/without constraints. Nonlinear systems of equations principles set the base for further development of Interior Optimization and Interior-Graphical Optimization [Casesnoves, 2016-7]. Mathematical proofs with mathematical definitions, algorithms, and nonlinear optimization equations are presented. From Graphical Optimization 3D optimization stages, it is proven that solution of nonlinear systems of equations is not unique in general. Software-engineering and computational simulations are shown with electronics superconductors and electronics physics applications. Extensions to similar applications for materials-tribology models and Biomedical Tribology are explained.
Hesperidin and SARS-CoV-2: New Light on the Healthy Functions of Citrus Fruit

Among the many approaches to COVID-19 prevention, the possible role of diet has so far been somewhat marginal. Nutrition is very rich in substances with a potential beneficial effect on health and some of these could have an antiviral action or in any case be important in modulating the immune system and in defending cells from the oxidative stress associated with infection. This short review draws the attention on some components of Citrus fruits and especially of the orange (Citrus sinensis), well known for its vitamin content, but less for the function of its flavonoids. Among the latter, hesperidin has recently attracted the attention of researchers, because it binds to the key proteins of the SARS-CoV-2 virus. Several computational methods, independently applied by different researchers, showed that hesperidin has a low binding energy both with the coronavirus "spike" protein, and with the main protease that transforms the early proteins of the virus (pp1a and ppa1b) into the complex responsible for viral replication. The affinity of hesperidin for these proteins is comparable if not superior to that of common chemical antivirals. The preventive efficacy of vitamin C, at dosage attainable by diet, against viral infections is controversial, but recent reviews suggest that this substance may be useful in case of increased stress on the immune system. Finally, the reasons that suggest undertaking appropriate research on the Citrus fruits addition in the diet, as a complementary prevention and treatment of COVID-19, are discussed.
The Psychological State and Changes in the Routine of the Patients with Rheumatic Diseases during the First Month of the Lockdown of the Coronavirus Disease (COVID-19) Outbreak in Turkey

Objective: We hypothesized that patients with rheumatic diseases (RD) would have increased psychological distress during the COVID-19 outbreak; therefore assessed their psychological symptoms and changes in their routine. Methods: A web-based study was conducted in a cross-sectional design in 3 groups of participants: 1. patients with RD, 2. hospital workers and 3. high-school teachers/non-medical academic staff. Psychiatric status was evaluated using Hospital Anxiety and Depression Scale and Impact of Event Scale-Revised scale.Results: We studied 771 patients with RD, 535 hospital workers, and 917 teachers/academic staff. Most of the patients with RD were unwilling to go to the hospital (86 %) while 22 % discontinued their medications (78%). Biological DMARDS were the most frequent drugs whose doses were altered. Only 4 % were willing to take hydroxychloroquine for protection. Moreover, the frequency of anxiety (20%), depression (43%) and post-traumatic stress (28%) among patients with RD were found to be comparable to that among the teachers/academic staff (23%, 43% and 29%, respectively), whereas significantly less than that among the hospital workers (40%, 62% and 46%, respectively) (p<0.0001). Female gender, over social media exposure, comorbid disease, or a psychiatric disorder were found to be independently associated with psychiatric symptoms in total study population. Conclusions: The majority of the patients were unwilling to attend outpatient visits and one fifth skipped or stopped their immunosuppressive agents. Psychiatric symptoms in patient’s and teacher’s populations were of considerable clinical concern, despite being significantly lower than that observed among the hospital workers.
Application of Chemometric Methods in UV-Vis Absorption Spectroscopic Studies of Uranyl Ion Dimerization Reaction in Aqueous Solutions

Factor analysis and seif modeling were used as new methodologies to investigate uv-vis absorption spectra of uranyl (0.08 M) aqueous solutions (pH = 3.16, at the ambient temperature) as a function of temperature (8°C-75°C). The study indicated that the above system can be described as a twocomponent system involving equilibrium between UOl"̂ and (U02)2(0H)2"^. The pure spectrum for the dimeric species is extracted from the broad overlapping features via a self-modeling method. In addition, this method allows spectrophotometric determination of the reaction enthalpy for the dimerization reaction.
Salivary Biomarkers and Oral Health in Liver Transplant Recipients, with an Emphasis on Diabetes

Salivary biomarkers have been linked to various systemic diseases. We examined the association between salivary biomarkers, periodontal health, and microbial burden in liver transplant (LT) recipients with and without diabetes, after transplantation. We hypothesized that diabetic recipients would exhibit impaired parameters. This study included 84 adults who received an LT between 2000 and 2006 in Finland. Dental treatment preceded transplantation. The recipients were re-examined, on average, six years later. We evaluated a battery of salivary biomarkers, microbiota, and subjective oral symptoms. Periodontal health was assessed, and immunosuppressive treatments were recorded. Recipients with impaired periodontal health showed higher matrix metalloproteinase-8 (MMP-8) levels (p < 0.05) and MMP-8/tissue inhibitor of matrix metalloproteinase 1 (TIMP1) ratios (p < 0.001) than recipients with good periodontal health. Diabetes post-LT was associated with impaired periodontal health (p < 0.05). No difference between groups was found in the microbial counts. Salivary biomarker levels did not seem to be affected by diabetes. However, the advanced pro-inflammatory state induced by and associated with periodontal inflammation was reflected in the salivary biomarker levels, especially MMP-8 and the MMP-8/TIMP-1 molar ratio. Thus, these salivary biomarkers may be useful for monitoring the oral inflammatory state and the course of LT recipients.