Miracle-dz/UniFAR-FTUs huggingface dataset:
tumor-related Rac 1 b in colorectal cells Phosphorylation of SRSF 1 by SRPK 1 regulates alternative splicing of

The premessenger RNA of the majority of human genes can generate various transcripts through alternative splicing, and different tissues or disease states show specific patterns of splicing variants. These patterns depend on the relative concentrations of the splicing factors present in the cell nucleus, either as a consequence of their expression levels or of post-translational modifications, such as protein phosphorylation, which are determined by signal transduction pathways. Here, we analyzed the contribution of protein kinases to the regulation of alternative splicing variant Rac1b that is overexpressed in certain tumor types. In colorectal cells, we found that depletion of AKT2, AKT3, GSK3β, and SRPK1 significantly decreased endogenous Rac1b levels. Although knockdown of AKT2 and AKT3 affected only Rac1b protein levels suggesting a post-splicing effect, the depletion of GSK3β or SRPK1 decreased Rac1b alternative splicing, an effect mediated through changes in splicing factor SRSF1. In particular, the knockdown of SRPK1 or inhibition of its catalytic activity reduced phosphorylation and subsequent translocation of SRSF1 to the nucleus, limiting its availability to promote the inclusion of alternative exon 3b into the Rac1 pre-mRNA. Altogether, the data identify SRSF1 as a prime regulator of Rac1b expression in colorectal cells and provide further mechanistic insight into how the regulation of alternative splicing events by protein kinases can contribute to sustain tumor cell survival.
The Effectiveness of Clove Extract on Oxidization-Induced Changes of Structure and Gelation in Porcine Myofibrillar Protein

This study aimed to investigate the structural characteristics and gelation behavior of myofibrillar proteins (MPs) with or without clove extract (CE) at different oxidation times (0, 1, 3, and 5 h). Circular dichroism spectra and Fourier transform infrared spectra showed that samples with CE addition had significantly higher α-helix content after oxidation than those without CE addition. However, prolonged oxidation (5 h) would make the effect of CE addition less pronounced. Similarly, the ultraviolet-visible (UV) spectra analysis revealed that CE controlled the oxidative stretching of the protein tertiary structure and reduced the exposure of aromatic amino acids. In addition, the particle size and turbidity values of the CE group significantly decreased after oxidation compared to the non-CE group. CE increased the gel strength by 10.05% after 5 h of oxidation, which could be observed by scanning electron microscopy (SEM) as a more homogeneous, dense, less porous, network-like gel structure. Therefore, these results showed that oxidation induced significant changes in the structure and gel properties of MPs, but the addition of CE effectively inhibited these destructive changes.
EXAMINING THE ACADEMIC PERFORMANCE OF THE NEWLY UPGRADED RURAL SECONDARY SCHOOLS IN MUMBWA DISTRICT OF CENTRAL PROVINCE, ZAMBIA

This study examined the academic performance of the newly upgraded rural secondary schools in Mumbwa District of Central Province in Zambia. The study had a total of 90 participants. The study employed both qualitative and quantitative methods as a descriptive survey. Questionnaires and interview schedules were used. The findings of the study revealed that the upgraded rural secondary schools had poor learning and teaching environments due to shortage of classroom space, facilities such as libraries and science laboratories. Apart from that, the study revealed that these rural upgraded secondary schools lacked adequate teaching and learning materials coupled with inadequate and under-qualified teaching staff which contributed greatly to the poor performance of learners in these schools. The study revealed that the academic performance of pupils in the three years was below 50% pass rate. The study recommends that the Ministry of General Education and other stakeholders should build more infrastructure and improve the existing ones in these upgraded rural secondary schools. Apart from that, the Ministry of General Education should provide adequate and prescribed teaching and learning materials to these schools to avoid teaching learners using outdated materials which may be contributing to poor performance. Further, the Ministry of General Education should send more qualified teachers to these upgraded rural secondary schools. This would improve the performance of learners and hence meet the aspiration of the Ministry of General Education for all learners both in urban and rural secondary schools. Article visualizations:
Relationship between black ownership, capital structure and company performance

ownership structure and performance continues to attract the attention of scholars in the financial field (Aluchna & Kaminski 2017). Previously, studies focused on ownership distribution and relationships between principals and agents, as illustrated in the conflict between shareholders and managers (Aluchna & Kaminski 2017; Coles, Lemmon & Meschke 2012; Kumar & Zattoni 2014). Subsequently, apart from the effect of a controlling shareholder and multiple large shareholders (Jara-Bertin, López-Iturriaga & López-de-Foronda Background: The notion that a company’s ownership structure may affect performance and capital structure has been the attraction, but few studies have looked at the effect of black ownership (BO). Aim: This paper contributes to the literature by examining the possible interactions between BO, performance, and capital structure. Within an agency cost framework, the study indicated that the distribution of equity ownership among black shareholders might significantly influence the performance and leverage of companies listed on the Johannesburg Stock Exchange (JSE). Setting: Altogether 187 companies on the JSE were selected for the period of 2007 to 2014. Method: Data on the sampled companies were sourced from the Iress database, a prominent source of financial data in South Africa, as well as annual reports. The research used a pooled fixed-effects model, random effects model and two-step generalised method of moments in the analysis. Results: The findings of the research provided support for the agency cost theory. The empirical findings indicated that BO was negatively correlated with debt ratio (long-term debt) and performance (Tobin’s Q [TQ]). Surprisingly, BO was positively and significantly correlated with return on assets. Finally, the empirical findings indicated that the proportion of long-term debt and total debt based on market value was lower for BO than for total ownership, while TQ was higher for BO than for total ownership. The finding supports the prediction that companies with a relatively small proportion of black ownership cannot support high leverage and high performance Conclusion: Although the introduction of BO by way of government intervention has been partially successful, more can be done to improve the relationship between the proportion of BO, performance and capital structure in a developing economy.
Semantic interoperability for an integrated product development process: a systematic literature review

Global competitiveness challenges manufacturing industry to rationalise different ways of bringing to the market new products in a short lead-time with competitive prices whilst ensuring higher quality levels and customisation. Industries need to effectively share heterogeneous information during Product Development Process (PDP) within and across their institutional boundaries to be competitive. However, problems with misinterpretation and mistakes have been identified during information exchange due to the semantic interoperability obstacles. Thus, this research proposes a systematic literature review to identify the main researches and the milestones reference works on semantic interoperability field. A rigorous methodology was conducted in different databases, covering the articles published in scientific journals from 2005 to 2015 as a preliminary study had indicated that the incidence of articles related to the subject was more frequent from the second half of the 2000s. The research structure consisted of four steps: Survey – searching, analysis and selection of recent researches; Categorisation – categorisation of the selected papers; References citation frequency analysis – the selected papers were analysed and the main researches and milestones references were identified; and Main researches critical analysis – the main researches were analysed for their contributions and limitations, their contributions and limitations, resulting in 14 selected scientific articles and 8 identified milestones references. It is evident that this field has interesting perspectives on future research opportunities on semantic interoperability of information issues across PDP, contributing to the new concepts of future factories.
International Journal of Evaluation and Research in Education (IJERE)

Received Jul 29, 2022 Revised Jun 3, 2023 Accepted Jun 30, 2023 Dyslexia is often described as the most common learning disability among the students that affect their ability to read and write. Children with dyslexia persist to their reading difficulties into adolescence and adulthood if without effective intervention and instruction. Therefore, this paper aims to review on the current state of available interventions for children with dyslexia in Malaysia and compare the interventions conducted outside Malaysia instead of to identify the frequently used for assistive technology tools in improving literacy skills. A total of 30 articles published between 2009 and 2021 that met the inclusive criteria were downloaded from electronic databases such as Scopus, SpringerLink and ScienceDirect. The interventions were divided into two categories which are phonological-based and assistive technologybased. The findings indicated that most of the interventions are focused on assistive technology tools and mobile learning applications become the favorite choice in Malaysia to assist students with dyslexia in ameliorating their learning difficulties. However, the developed mobile learning applications are not focused on teaching phonics and combined all three language skills (reading, spelling, and writing) in an application. Hence, it is imperative that researchers in Malaysia take into account to develop more mobile learning applications that focus on English language phonics and encompass three language skills (reading, spelling and writing) in an application for students with dyslexia.
Information behaviour of Nigerian undergraduates in the world of Web 2.0: The case of Federal University of Petroleum Resources, Delta State, Nigeria, a specialized university

This study investigated the information behaviour of Nigerian undergraduates in the world of Web 2.0 at the Federal University of Petroleum Resources, Nigeria. The study is drawn from a doctoral thesis that used a mixed methods approach. The population and sample of the study was a total of 803 undergraduate students. Three research questions which focused on the information needs, information resources and infrastructure, and barriers to information seeking were answered using a questionnaire. The study revealed that students need information both for academic purposes and in their everyday life experiences. The data provide support for the convenience school of thought. It seems that time constraints and the inconvenience of traditional sources might be critical factors in the choices that students make in their information seeking. The barriers which students experience are both physical and intellectual. The physical barriers relate to technical issues such as the system freezing, server down time, access speed, and erratic power supply. The intellectual barriers concern their inability to choose appropriate subject headings, keywords, formulating search strategies, and choosing appropriate databases.
Controlled Auditory Distance Perception using Binaural Headphone Reproduction - Evaluation via Listening Tests

An accurate reproduction of an auditory scene includes not only the correct reproduction of the direction of a sound source but rather the reproduction of the distance from the listener. Based on a Master's thesis at Ilmenau University of Technology, two algorithms for a controlled modification of the distance perception in not individualized binaural headphone reproduction will be evaluated. The algorithms are based on a detailed analysis of measured binaural room impulse responses (BRIRs) and a detailed consideration of the mechanisms of the human hearing range. The algorithms change systematically distance-dependent properties of the impulse responses. It is possible to control the perceived distance by calculating modified BRIRs. The distance perception is evaluated with listening tests. We used BRIRs from two rooms with different room acoustics measured using an artificial head of several distances to the listening position. As basis for the newly synthesized BRIRs of different distances only measured BRIRs from one distance are used. A multi-stimulus and a forced-choice listening test are applied rate the perception of distance and perceived externality by reproduction via a binaural headphone system. The results show that the measured BRIRs and the newly synthesized BRIRs cause similar distance perception. However the distance perception of the synthesized BRIRs, in contrast to the measured BRIRs, is more dependent on the synthesized room and its acoustics.
Exploring persuasion in the design of a sustainability accounting service

This master thesis explores the relatively new design space of products that attempt to persuade companies to become more sustainable. Research through design has been applied by working with a company called Normative and their web application, which lets companies measure a number of sustainability metrics from data about all the purchases that the company has made. For this purpose, relevant theory has been reviewed, and potential users have been interviewed. Using the insights from these activities, a new prototype of Normative’s product, that attempts to persuade companies to become more sustainable, has been created. With insights gained from this design and research, a set of challenges that need to be considered when creating products that attempt to make companies more sustainable have been formulated.
Cooperative multi-robot manipulation under uncertain kinematic grasp parameters

Autonomous robot systems are the key technology in a variety of industrial, logistic and domestic applications. When employing several robots in a manipulation task, the core challenge is the coordination of the robotic team. This thesis addresses the modeling, control and coordination design for cooperating manipulators when no global coordinate system is available for accomplishing the task. The presented approach addresses in particular the distributed coordinate knowledge of the multi-robot team.
Cheating at Digital Exams - Vulnerabilities and Countermeasures

In today’s world where everything is increasingly done on computers, university exams are traditionally lagging behind and are still conducted using pen and paper for the most part. Recently, however, NTNU has started a slow migration process towards digital exams using Safe Exam Browser and Inspera Assessment on private devices brought by the students on the exam day. Digital exams have the potential to resolve some of the issues with old style pen and paper exams, however, that is not without bringing its own set of problems into the mix. In this thesis, I look at specifically how digital exams using Safe Exam Browser and Inspera Assessment software might enable students to cheat on the exams in ways that were not possible on pen and paper exams. The main focus is on the interactions between the three components Safe Exam Browser, Inspera Assessment and the students own computer to look at both technical and theoretical ways that students can cheat during digital exams at NTNU. And where possible, I provide solutions/mitigations to any problems I do discover. The current solution employed by NTNU to facilitate digital exams for students does have several problematic security vulnerabilities. There are several ways a student can manage to cheat on a digital exam that they would not be able to do using a traditional pen and paper exam. However, the work to improve digital exams are important, and there are definitely improvements that can bemade. While
Geometry Aware Compressive Analysis of Human Activities : Application in a Smart Phone Platform

Continuous monitoring of sensor data from smart phones to identify human activities and gestures, puts a heavy load on the smart phone’s power consumption. In this research study, the non-Euclidean geometry of the rich sensor data obtained from the user’s smart phone is utilized to perform compressive analysis and efficient classification of human activities by employing machine learning techniques. We are interested in the generalization of classical tools for signal approximation to newer spaces, such as rotation data, which is best studied in a non-Euclidean setting, and its application to activity analysis. Attributing to the non-linear nature of the rotation data space, which involve a heavy overload on the smart phone’s processor and memory as opposed to feature extraction on the Euclidean space, indexing and compaction of the acquired sensor data is performed prior to feature extraction, to reduce CPU overhead and thereby increase the lifetime of the battery with a little loss in recognition accuracy of the activities. The sensor data represented as unit quaternions, is a more intrinsic representation of the orientation of smart phone compared to euler angles (which suffers from gimbal lock problem) or the computationally intensive rotation matrices. Classification algorithms are employed to classify these manifold sequences in the non-Euclidean space. By performing customized indexing (using K-means algorithm) of the evolved manifold sequences before feature extraction, considerable energy savings is achieved in terms of smart phone’s battery life.
The Effect of Heavy Stocking on the Worm Burden under a System of Rotational Grazing

The developments which have taken place during recent years in the scientific management of grassland have resulted in a marked improvement both in the quality and in the quantity of the herbage produced. This has been brought about partly by frequent manuring, particularly with nitrogenous manures, and also by ensuring the close cropping of the grass at frequent intervals.
Effects of hands-on instructional strategy on senior school students’ performance in waves

The research examined the effects of hands-on teaching strategy on senior school learners’ performance waves in Ilorin, Nigeria. Senior secondary school (SSS2) science students were sampled at intact classes using a purposive sampling technique. Researcher-designed instructional packages on waves and Physics achievement test on waves (PATW) were the instruments employed. The gathered data were analysed with the use of descriptive and inferential statistics. Percentage, mean and standard deviation were employed in answering the research question. Meanwhile, Analysis of Variance (ANOVA) was utilised in testing the hypotheses formulated at a 0.05 alpha level. The study showed that students’ performance exposed to hands-on instructional strategy was very impressive, while students’ performance exposed to traditional strategy was low, there was a significant effect of hands-on instructional technique on the performance of students in waves and no statistically significant collaborative effect of hands-on instructional technique and students’ gender on performance in waves. It was suggested that hands-on instructional strategies should be integrated and used to make teaching and learning more concrete and active based for both teachers and students.
The Relationship Between Assimilation and Difference Motives With Health and Well-Being in a Sample of Japanese Adults

Research of factors influencing our health and wellbeing is omnipresent. Yet, research about how basic human motives influence human physical health and subjective well-being (SWB) is scarce. This thesis extends previous research on value fit and investigates the relationship of assimilation and difference motives and a fit in these motives with SWB and overall health. It was hypothesized that (a) person-environment motive fit in assimilation and difference motives has a beneficial effect on SWB and overall health and that (b) assimilation motive itself has a positive effect on SWB and health whereas difference motive itself negatively influences these variables. Data from the TEP 10 project were analyzed within a sample of 1240 Japanese adult participants. Overall, results provide little support for the present hypotheses. Significant results in line with the hypotheses show that a fit in assimilation motive has an advantageous effect on positive emotions experienced during the last week. Further significant results contradict the present hypotheses and show that assimilation motive fit has a detrimental effect on negative emotions experienced in the last week, that difference motive fit negatively influences overall health ratings and that assimilation motive itself negatively influences negative emotions experienced in the last week and day, as well as overall health ratings. For future research it would be beneficial to use more differentiated, implicit measures and, eventually, derive interventions on how to support individuals who do not experience the investigated beneficial effects on their subjective well-being.
Baker’s (1992) Used Strategies in Translating Somatic Idioms by Learners of English at the Faculties of Arts and Languages, Sohag

The present study aims to explore the obstacles that face learners of English in translating somatic idioms (idioms that contain the names of body organs). It also investigates the main factors behind such obstacles. In addition, it highlights the adopted strategies by learners in the translation process. Moreover, five quizzes were given to a sample of fourth-year students, majoring in English, at the Faculties of Arts and Languages in Sohag University during the second semester (2021-2022). Baker's (1992) translation strategies and Frenando's (1996) categorization of idioms (literal- semi-literal- pure) formed the basis of the theoretical part of this research. The results showed that 4th-year students encountered several obstacles because the lack of their cultural awareness failed in empowering them to decipher the equivalent or the intended meaning effectively and they were unfamiliar with the translation strategies. Furthermore, in translating from English into Arabic the literal translation was the most used strategy in terms of the frequency of use, with a percentage (42%), and the least adopted strategy is omission with a percentage (8%). On the other hand, in translating from Arabic into English paraphrasing strategy was the primary strategy with a percentage (51%). However, omission occupied the lowest rank with a percentage (2.5%). In the end, some of the study’s recommendations were highlighted and discussed.