Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder

The relationship between depression and insomnia is bidirectional and both conditions need to be treated adequately, especially in a vulnerable neurodevelopmental stage of adolescence. This study aimed to evaluate the effects of antidepressant treatment using vortioxetine (VOR) on the sleep architecture of depressed adolescents by using video-polysomnography (v-PSG), which has not been researched before. The v-PSG was performed on 30 adolescent in-patients (mean age of 15.0 years ± 1.5 SD, 21 girls) treated with VOR (dosage of 10/15/20 mg/day) administered orally once a day, before and after VOR treatment. The evaluated parameters were conventional sleep parameters, sleep fragmentation parameters, and selected spectral power indices. Symptoms of depression and insomnia before and after the treatment period were evaluated using valid and reliable questionnaires (the Children´s Depression Inventory and the Athens Insomnia Scale). Depressed adolescents showed higher REM latency and decreased REM sleep percentage after treatment than before the treatment period (p = 0.005, p = 0.009, respectively). Our study revealed REM suppression (increased REM latency and reduced REM sleep percentage), indicating altered sleep architecture as a potential result of VOR treatment, which seems to be dose-dependent.
New Construction of Asynchronous Channel Hopping Sequences in Cognitive Radio Networks

The channel-hopping-based rendezvous is essential to alleviate the problem of under-utilization and scarcity of the spectrum in cognitive radio networks. It dynamically allows unlicensed secondary users to schedule rendezvous channels using the assigned hopping sequence to guarantee the self-organization property in a limited time. In this paper, we use the interleaving technique to cleverly construct a set of asynchronous channel-hopping sequences consisting of d sequences of period xN2 with flexible parameters, which can generate sequences of different lengths. By this advantage, the new designed CHSs can be used to adapt to the demands of various communication scenarios. Furthermore, we focus on the improved maximum-time-to-rendezvous and maximum-first-time-to-rendezvous performance of the new construction compared to the prior research at the same sequence length. The new channel-hopping sequences ensure that rendezvous occurs between any two sequences and the rendezvous times are random and unpredictable when using licensed channels under asynchronous access, although the full degree-of-rendezvous is not satisfied. Our simulation results show that the new construction is more balanced and unpredictable between the maximum-time-to-rendezvous and the mean and variance of time-to-rendezvous.
HIF-2α Controls Expression and Intracellular Trafficking of the α2-Subunit of Na,K-ATPase in Hypoxic H9c2 Cardiomyocytes

The Na,K-ATPase (NKA) pump plays essential roles for optimal function of the heart. NKA activity decreases in necropsy materials from ischemic heart disease, heart failure and in experimental models. Cellular adaptation to hypoxia is regulated by hypoxia-induced transcription factors (HIF); we tested whether HIFs are involved in regulating the expression and intracellular dynamics of the α2-isoform of NKA (α2-NKA). HIF-1α and HIF-2α expression was suppressed in H9c2 cardiomyocytes by adenoviral infection, where cells were kept in 1% O2 for 24 h. The silencing efficiency of HIFs was tested on the mRNA and protein expression. We measured the mRNA expression of α2-NKA in HIF-silenced and hypoxia-exposed cells. The membrane and intracellular expression of α2-NKA was measured after labelling the cell surface with NHS-SS-biotin, immunoprecipitation and Western blotting. Hypoxia increased the mRNA expression of α2-NKA 5-fold compared to normoxic cells in an HIF-2α-sensitive manner. The plasma membrane expression of α2-NKA increased in hypoxia by 2-fold and was fully prevented by HIF-2α silencing. Intracellular expression of α2-NKA was not affected. These results showed for the first time that in hypoxic cardiomyocytes α2-NKA is transcriptionally and translationally regulated by HIF-2α. The molecular mechanism behind this regulation needs further investigation.
Impacts of landscape attributes on carbon sequestration during the transition from conventional to conservation management practices on a Coastal Plain field

ABSTRACT: Field-scale experiments on degraded soils comparing management systems would facilitate a better understanding of the soil organic carbon (C) landscape dynamics associated with transition to conservation systems. We assessed the effects of soil management practices and terrain attributes on soil organic C in a 9 ha (22.2 ac) Alabama field (Typic and Aquic Paleudults). Treatments were established in strips across the landscape in a corn (Zea mays L.)-cotton (Gossypium hirsutum L.) rotation. Treatments included a conventional system (chisel plowing/disking without cover crops) with or without dairy manure, and a conservation system (no-till and cover crops) with and without manure. A soil survey, topography, soil electrical conductivity, initial soil organic C and soil texture were used to delineate management zones or clusters. After one rotation cycle (30 months), averaged across 240 positions distributed over the entire field, no-till or conventional tillage + manure increased soil organic C (0 to 5 cm; 0 to 2 in depth) by -50 percent compared to conventional tillage (7.34 and 7.62 vs. 5.02 Mg ha−1; 3.28 and 3.40 vs. 2.24 t ac−1, respectively); but no-till+manure increased soil organic C by 157 percent. Initial soil organic C content was the most common correlated variable with soil organic C changes (SOC) across the landscape for all treatments and conservation systems had greater soil organic C increases relative to conventional systems at low soil quality landscape positions. Our results show the potential to sequester C using high-residue producing conservation systems and manure is scale dependent, and may be higher than previously expected for degraded soils in the southeastern United States.
Are educator-created (dis)empowering climates equally associated with motivational experiences in physical education pre-service teachers as in foreign language pre-service teachers?

Guided by self-determination theory, the objective of the present research was to examine the differences between physical education (PE) and foreign language (FL) pre-service teachers in terms of the associations between perceived educator-created (dis)empowering climates and need-based experiences and motivation. A convenience sample of 246 PE and 208 FL pre-service teachers (57.08% women, Mage=24.92, SD=4.07) participated in this cross-sectional research. All the participants came from eight Andalusian public universities: Almería (19.8%), Cádiz (5.7%), Córdoba (3.7%), Granada (32.2%), Huelva (3.5%), Jaén (4.8%), Málaga (16.1%) and Sevilla (14.1%). The participants completed the following scales: the Educator-Created Empowering and Disempowering Climate Questionnaire, the Basic Psychological Needs Satisfaction Scale, the Psychological Needs Thwarting Scale, and the Academic Motivation Scale. The results showed that PE pre-service teachers scored significantly higher than FL pre-service teachers in disempowering climate, need satisfaction and amotivation. The results from the multi-group path analysis revealed that, overall, empowering and disempowering climates were differentially associated with the motivational outcomes between the PE and FL pre-service teachers. More specifically, FL pre-service teachers had slightly higher associations between empowering climates and need satisfaction, and between disempowering climates and need frustration. Conclusions: the findings underscore the importance not only of teacher educators creating empowering climates.
Brain decoding: toward real-time reconstruction of visual perception

In the past five years, the use of generative and foundational AI systems has greatly improved the decoding of brain activity. Visual perception, in particular, can now be decoded from functional Magnetic Resonance Imaging (fMRI) with remarkable fidelity. This neuroimaging technique, however, suffers from a limited temporal resolution ($\approx$0.5 Hz) and thus fundamentally constrains its real-time usage. Here, we propose an alternative approach based on magnetoencephalography (MEG), a neuroimaging device capable of measuring brain activity with high temporal resolution ($\approx$5,000 Hz). For this, we develop an MEG decoding model trained with both contrastive and regression objectives and consisting of three modules: i) pretrained embeddings obtained from the image, ii) an MEG module trained end-to-end and iii) a pretrained image generator. Our results are threefold: Firstly, our MEG decoder shows a 7X improvement of image-retrieval over classic linear decoders. Second, late brain responses to images are best decoded with DINOv2, a recent foundational image model. Third, image retrievals and generations both suggest that high-level visual features can be decoded from MEG signals, although the same approach applied to 7T fMRI also recovers better low-level features. Overall, these results, while preliminary, provide an important step towards the decoding -- in real-time -- of the visual processes continuously unfolding within the human brain.
The Geology of Beadnell, in the County of Northumberland, with a Description of Some Annelids of the Carboniferous Formation

A section along the coast from Ebbs Nook to Annstead Bay, of nearly one and a half miles in length, exhibits a fine series of rocks belonging to the Mountain Limestone Formation. Thick sandstones and limestones, shales with ironstone, and coal-seams are intercalated with each other; and these strata are traversed by a lead-vein and a basaltic dyke. As we wander along the shore, we meet with evidences of sea-deposits in the limestones and calcareous shales, wherein are embedded many corals and mollusks; the sandstones, shales, and coal afford relics of the vegetation of the Carboniferous Era; some slaty sandstones give distinct indications of ancient shallow seas and coast-lines, whereon the waves broke gently and over which worms crawled; while the basaltic dyke tells of the play of internal forces, rending asunder the vast mass of stratified rocks, and pouring molten lava into the fissures.
The Role and Therapeutic Implications of Inflammation in the Pathogenesis of Brain Arteriovenous Malformations

Brain arteriovenous malformations (bAVMs) are focal vascular lesions composed of abnormal vascular channels without an intervening capillary network. As a result, high-pressure arterial blood shunts directly into the venous outflow system. These high-flow, low-resistance shunts are composed of dilated, tortuous, and fragile vessels, which are prone to rupture. BAVMs are a leading cause of hemorrhagic stroke in children and young adults. Current treatments for bAVMs are limited to surgery, embolization, and radiosurgery, although even these options are not viable for ~20% of AVM patients due to excessive risk. Critically, inflammation has been suggested to contribute to lesion progression. Here we summarize the current literature discussing the role of the immune system in bAVM pathogenesis and lesion progression, as well as the potential for targeting inflammation to prevent bAVM rupture and intracranial hemorrhage. We conclude by proposing that a dysfunctional endothelium, which harbors the somatic mutations that have been shown to give rise to sporadic bAVMs, may drive disease development and progression by altering the immune status of the brain.
White Matter Integrity Abnormalities in Healthy Overweight Individuals Revealed by Whole Brain Meta-Analysis of Diffusion Tensor Imaging Studies

Objective This study aimed to conduct a coordinate-based meta-analysis (CBMA) to investigate white matter (WM) abnormalities in healthy individuals with overweight or obesity. Methods A systematic literature search using Web of Science and PubMed datasets was performed. Original investigations that used diffusion tensor imaging (DTI) to explore fractional anisotropy (FA) differences between healthy overweight/obese individuals and normal weight controls were collected. The meta-analysis was conducted using the seed-based d mapping (SDM) software, employing stringent thresholds for significance. Sensitivity analyses and meta-regression analysis were also performed to examine the robustness of the results and explore potential associations with age and body mass index (BMI). Results The analysis included five studies comprising 232 overweight/obese individuals and 219 healthy normal weight controls. The findings showed that overweight/obese individuals exhibited reduced fractional anisotropy (FA) in specific regions, namely, the right superior longitudinal fasciculus (SLF), the splenium of the corpus callosum (CC), and the right median network, cingulum. Meta-regression analysis further revealed that these FA reductions were associated with age. Conclusion These findings provided insights into the potential impact of overweight/obesity on cognition, emotion, and neural functions and highlighted the significance of early prevention and intervention for overweight on the basis of neuroimaging.
A Privacy-Preserving Approach Against Eavesdropping Attacks on Remote State Estimation for Cyber–Physical Systems

This brief is concerned with the issue of privacy preservation against eavesdropping attacks on remote state estimation for cyber-physical systems. We aim to propose a privacy-preserving approach for remote state estimation to achieve an optimal trade-off between the estimation performance and the privacy-preserving level. We first investigate the design of a privacy-preserving scheme and present a closed-form solution for a signal system. Then, we present how to design the privacy-preserving single for multi-systems. Note that different subsystems or local state information possess different estimation performance and privacy-preserving requirements, we are inspired to propose a novel importance-aware privacy-preserving scheme. Correspondingly, we present how to design a privacy-preserving scheme for multi-systems to achieve an overall balance between estimation performance and privacy preservation. Finally, some numerical examples are given to illustrate the theoretical results.
Model-driven Privacy

Data protection regulations in many countries require IT systems to implement baseline privacy requirements like purpose limitation and consent as mandated by the GDPR. Such requirements are often specified in the system’s privacy policy and are challenging to implement as system developers must address them consistently and in a cross-cutting manner. Moreover, without a formal connection between a system’s privacy policy and its implementation, the system’s correctness and evolution are extremely difficult to attain. We propose a model-driven development methodology that incorporates privacy policies into the system design. Namely, we define a system’s privacy model, which has precise semantics and is used to specify privacy policies. We provide semantic-preserving model transformations that generate system implementations that enforce the given privacy policies by design. We implement two such model transformations, targeting C# and Python system implementations. We evaluate our methodology on three substantial case studies and show the enforcement of privacy policies related to purpose limitation and consent. Our evaluation also demonstrates our approach’s generality, effectiveness, and modest overhead.
Is there a visitor effect on Abyssinian Ground Hornbills (Bucorvus abyssinicus), Papuan Wreathed Hornbills (Aceros plicatus), Wrinkled Hornbills (Aceros corrugatus) and Toco Toucans (Ramphastos toco) in a captive zoo environment?

Research into the possible effects that zoo visitors have on the captive animals they come to visit is still relatively poorly understood. Most of the studies all ready completed have used non-human primate subjects, but there is a distinct lack of studies using non-primate species. One of the groups that are in particular need of this kind of research is birds. This study examines a potential visitor effect in captive Abyssinian Ground Hornbills (Bucorvus abyssinicus), Papuan Wreathed Hornbills (Aceros plicatus), Wrinkled Hornbills (Aceros corrugatus) and Toco Toucans (Ramphastos toco) at Paignton Zoo Environmental Park®. This study also investigates the evenness of enclosure use, using the original Spread of Participation Index. Chi-Squared Association Tests revealed conflicting potential visitor effects on behaviour within the Abyssinian Ground Hornbills. Significant associations were also seen in a number of individuals between height (m) and visitor number and location and visitor number, with the majority of individuals appearing in the outside zones more frequently with increasing visitor density. However, this study could not establish what aspect of visitor presence was causing these effects. All the birds, with the exception of Abyssinian Ground Hornbill 1 and 2 showed unevenness in enclosure use. Establishing a potential visitor effect can be beneficial with regards to the welfare of the subject animals. Should a stressful effect be seen, then changes can be implemented to reduce this and improve living conditions and health for the animals.
The Effect of Explicit Suicide Language in Engagement With a Suicide Prevention Search Page Help-Seeking Prompt: Nonrandomized Trial.

BACKGROUND Given that signage, messaging, and advertisements (ads) are the gateway to many interventions in suicide prevention, it is important that we understand what type of messaging works best for whom. OBJECTIVE We investigated whether explicitly mentioning suicide increases engagement using internet ads by investigating engagement with campaigns with different categories of keywords searched, which may reflect different cognitive states. METHODS We ran a 2-arm study Australia-wide, with or without ads featuring explicit suicide wording. We analyzed whether there were differences in engagement for campaigns with explicit and nonexplicit ads for low-risk (distressed but not explicitly suicidal), high-risk (explicitly suicidal), and help-seeking for suicide keywords. RESULTS Our analyses revealed that having explicit wording has opposite effects, depending on the search terms used: explicit wording reduced the engagement rate for individuals searching for low-risk keywords but increased engagement for those using high-risk keywords. CONCLUSIONS The findings suggest that individuals who are aware of their suicidality respond better to campaigns that explicitly use the word "suicide. " We found that individuals who search for low-risk keywords also respond to explicit ads, suggesting that some individuals who are experiencing suicidality search for low-risk keywords.
Huntington Study Group's Neuropsychology Working Group: Implementing Non‐Motor Diagnostic Criteria

The clinical diagnosis of manifest Huntington's disease (HD) relies on a high level of clinical confidence (99% confidence) of HD‐consistent motor signs. Longitudinal data have reliably identified cognitive and behavioral dysfunction predating clinical motor diagnosis by up to 15 years. Reliance on motor signs to establish a diagnosis of HD increases risk of early misdiagnosis or delayed diagnosis. Clinical neuropsychologists are uniquely positioned to advise on the clinical application of the Movement Disorder Society Task Force's recently proposed non‐motor diagnostic criteria for HD.
Lyrodus turnerae, a new teredinid from eastern Australia and the Coral Sea (Bivalvia: Teredinidae)

Lyrodus turnerae n. sp. , a species of Teredinidae, is described from specimens in tropical Australia and Papua New Guinea. The new species is characterized by the morphology of the pallets, with a dark periostracal cap sharply descending into a thin calcium cup. New and existing collection records of L. turnerae are presented, indicating a distribution range from coastal Papua New Guinea and the Bismarck Archipelago, extending along eastern Australia to New South Wales.
Marriage Law in Religious Court: Regulation and Decision on Marital Property in Sustainable Legal Development

Objective: The issue of divorce cases in family court has implications, resulting in the division of marital property. The object of the dispute is the house that wants to be divided equally. The case was in court decision No.205/Pdt.G/2016/PA.Ab for first instance, until the appeal process No.01/Pdt.G/2017/PTA.Ab second instance, and Supreme Court No.159K/Ag. /2018 third instance and final decision at fourth instance namely review No.6PK/Ag. /2019. The difference from all court decisions in the same case is due to avoid discrimination on children's rights. Methods: Qualitative research by using case approach in marriage law concerning marital property, specifically discussing some of the cases and decisions mentioned above, as well as obtaining decisions from related courts that may be reviewed and some supported from the results of religious court reports, although there are some parts of the judgment that are not published on the basis of court secrecy that maintains the privacy of the litigant community Results: The courts of first and second instance determine and divide the objects normatively by 50% presentation, but the courts of third and fourth instance are different and opposite, and in the final judgment, the objects of dispute are suspended and not distributed. Conclusion: The judge's judgment in the case ignored the rights of children who were still young children. If the object of dispute is divided by 50% presentation, the object must be auctioned and sold and the proceeds divided in half, but the litigant has no other place to live to protect the child and will ignore the child who does not have another house to live for the child. So, the judge does not distribute the object until the child is an adult, restoring the right to the child who was neglected after the divorce.
Mediating Role of Psychological Distress between Body Image Concerns and Sexual Functioning in Primiparous Women

The birth of a baby brings changes in the weight and body shape of a female, distorting their body image. Therefore, the aim of this study was to explore the relationship between body image concerns, psychological distress, and sexual functioning in primiparous women. A cross-sectional survey research design was used to recruit 120 primiparous women from gynecology clinics located in Punjab via purposive sampling. The participants' ages ranged from 18 to 35 years (M=26, SD=4.34). The data was collected through a survey booklet, including socio demographics and standardized assessment measures like the Body Image Concerns Inventory, Kessler's Psychological Distress Scale, and the Female Sexual Functioning Index. Descriptive statistics, Pearson product moment correlation, and mediation analysis were the main statistical tools used in this study. The study found a significant positive association between body image concerns and psychological distress. Similarly, body image concerns and psychological distress were negatively correlated with sexual functioning. The mediation analysis revealed that the association between body image concerns and sexual functioning was partially mediated by psychological distress. Increased body image concerns have a negative impact on the psychological and sexual well-being of primiparous women.