Miracle-dz/UniFAR-FTUs huggingface dataset:
The protective effect of kaempferol on heart via the regulation of Nrf2, NF‐κβ, and PI3K/Akt/GSK‐3β signaling pathways in isoproterenol‐induced heart failure in diabetic rats

This study was designed to delineate the effect of kaempferol (KF) on heart failure (HF) in diabetic rats. Streptozotocin‐induced male diabetic rats received KF orally at 10 and 20 mg/kg for 42 consecutive days. In last 2 days of the experimental period, isoproterenol was subcutaneously injected at 85 mg/kg to induce HF. The hearts were processed for hemodynamic, biochemical, molecular, and histological investigations. Systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure were elevated in KF‐treated HF‐induced diabetic rats. Moreover, KF treatment resulted in decreased fasting blood glucose and glycosylated hemoglobin levels with increased serum insulin levels. Besides, serum cardiac injury markers like troponin‐I, creatine kinase‐muscle/brain, lactate dehydrogenase, and brain natriuretic peptide levels were significantly reduced in KF treatment. KF treatment has shown decrease in cardiac heme oxygenase‐1, nuclear factor erythroid 2–related factor 2 (Nrf‐2), and γ‐glutamylcysteine synthetase with increased Keap1 mRNA levels. The cardioprotection of KF was improved by inhibition of apoptosis via blocking phosphorylation of Akt/glycogen synthase kinase (GSK)‐3β and p38 mitogen‐activated protein‐kinase/extracellular signal‐regulated kinases signaling pathways in HF‐induced diabetic rats. Moreover, reduced cardiac apoptosis in KF treatment was confirmed by decreased terminal deoxynucleotidyl transferase dUTP nick‐end labeling (TUNEL) positive cells, histopathological changes in HF‐induced diabetic rats. Therefore, the cardioprotective effect of KF is attributed to the regulation of Nrf2, nuclear factor kappa‐light‐chain‐enhancer of activated B cells, and Akt/GSK‐3β signaling pathways in HF‐induced diabetic rats.
CMAR_A_224583 10871..10882

*These authors contributed equally to this work Abstract: Extrahepatic cholangiocarcinoma (EHCC) is a rare malignant tumor, and current treatment methods are also relatively limited. Radical surgery is the only potentially curative method for the long survival time. However, despite undergoing radical resection, prognosis remained poor due to the high recurrence rate and distant metastasis. Therefore, adjuvant chemotherapy and radiotherapy should be offered to patients who have undergone surgery. Unfortunately, the low incidence of this disease has resulted in a lack of high-level evidence to confirm the importance of adjuvant chemotherapy or radiotherapy. At present, it is still controversial whether adjuvant therapy can prolong the survival of patients after operation, especially patients with negative margins or lymph nodes. Furthermore, standard regimens of adjuvant have not been identified. This review summarizes the currently available evidence of the effect of adjuvant therapy in the management of EHCC. Ultimately, we concluded that adjuvant therapy may improve survival in high-risk (positive margin or lymph node or advanced stage) patients and adjuvant concurrent chemoradiotherapy followed by chemotherapy may be the optimum selection for them. This needs to be verified by randomized prospective clinical trials.
Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell–cell and cell–extracellular matrix interactions

Integrin α6β4 is an essential, dynamic adhesion receptor for laminin 332 found on epithelial cells, required for formation of strong cell–extracellular matrix (ECM) adhesion and induced migration, and coordinated by regions of the β4C cytoplasmic domain. β4E, a unique splice variant of β4 expressed in normal tissue, contains a cytoplasmic domain of 231 amino acids with a unique sequence of 114 amino acids instead of β4C’s canonical 1089 amino acids. We determined the distribution of α6β4E within normal human glandular epithelium and its regulation and effect on cellular biophysical properties. Canonical α6β4C expressed in all basal cells, as expected, while α6β4E expressed within a subset of luminal cells. α6β4E expression was induced by three-dimensional culture conditions, activated Src, was reversible, and was stabilized by bortezomib, a proteasome inhibitor. α6β4C expressed in all cells during induced migration, whereas α6β4E was restricted to a subset of cells with increased kinetics of cell–cell and cell–ECM resistance properties. Interestingly, α6β4E presented in “ringlike” patterns measuring ∼1.75 × 0.72 microns and containing actin and CD9 at cell–ECM locations. In contrast, α6β4C expressed only within hemidesmosome-like structures containing BP180. Integrin α6β4E is an inducible adhesion isoform in normal epithelial cells that can alter biophysical properties of cell–cell and cell–ECM interactions.
Performance Evaluation of Two Commercially Available Portable Spectrometers to Non-Invasively Determine Table Grape and Peach Quality Attributes

Near-infrared (NIR) spectroscopy has been used to non-destructively and rapidly evaluate the quality of fresh agricultural produce. In this study, two commercially available portable spectrometers (F-750: Felix Instruments, WA, USA; and SCiO: Consumer Physics, Tel Aviv, Israel) were evaluated in the wavelength range between 740 and 1070 nm to non-invasively predict quality attributes, including the dry matter (DM), and total soluble solids (TSS) content of three fresh table grape cultivars (‘Autumn Royal’, ‘Timpson’, and ‘Sweet Scarlet’) and one peach cultivar (‘Cassie’). Prediction models were developed using partial least-square regression (PLSR) to correlate the NIR absorbance spectra with the invasive quality measurements. In regard to grapes, the best DM prediction models yielded an R2 of 0.83 and 0.81, a ratio of standard error of performance to standard deviation (RPD) of 2.35 and 2.29, and a root mean square error of prediction (RMSEP) of 1.40 and 1.44; and the best TSS prediction models generated an R2 of 0.97 and 0.95, an RPD of 5.95 and 4.48, and an RMSEP of 0.53 and 0.70 for the F-750 and SCiO spectrometers, respectively. Overall, PLSR prediction models using both spectrometers were promising to predict table grape quality attributes. Regarding peach, the PLSR prediction models did not perform as well as in grapes, as DM prediction models resulted in an R2 of 0.81 and 0.67, an RPD of 2.24 and 1.74, and an RMSEP of 1.28 and 1.66; and TSS resulted in an R2 of 0.62 and 0.55, an RPD of 1.55 and 1.48, and an RMSEP of 1.19 and 1.25 for the F-750 and SCiO spectrometers, respectively. Overall, the F-750 spectrometer prediction models performed better than those generated by using the SCiO spectrometer data.
The Inflammatory and Hemostatic Cardiovascular Risk Markers During Acute Hyperglycemic Crisis in Type 1 and Type 2 Diabetes

Summary Background We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p<0.001; B: p<0.001, C: p<0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p <0.001; C: p<0.05, D: p=0.001 μmol/L), respectively, at resolving AHC. However, CRP persisted higher (p<0.001, p<0.01), IL-6 lower (p<0.05, p<0.001), while homocysteine levels turned out to be similar to controls. Conclusions AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP
From biotech to bioeconomy: New empirical evidence on the technological transition to plant-based bioeconomy based on patent data

Nowadays environmental and climate issues have brought the topic of bioeconomy to the political agenda around the world. Plant-based bioeconomy (pBE) has a key role in securing sustainable supplies of energy, food and raw materials for increasingly aging and growing societies. However, the technological roots and development path of pBE are far from being fully understood. Accordingly, we seek to contribute to an in-depth understanding of how biotechnology innovations affected the emergence of bioeconomy by exploring the technological field evolution of plant-based patent applications between 1995 and 2015 in Germany. We employ patent citation data and conduct forward citation analysis to trace technological trajectories within plant-based biotechnology. We extend previous work by combining patent-based citation analysis with text-mining approach. Main path analysis allows the identification of main players within plant-based biotechnology over time. Our explorations reveal dominant and also peripheral technologies within the sphere of plant-based applications and provide us in this way with a more comprehensive understanding of the field ́s technological evolution. Our findings suggest a transition from basic biotechnological research towards more sustainabilityand medicine-related technological orientation in the field. #2002 Bremen Papers on Economics & Innovation From biotech to bioeconomy New empirical evidence on the technological transition to plantbased bioeconomy based on patent data Muhamed Kudic* Mariia Shkolnykova* *University of Bremen, Max-von-Laue-Straße 1, 28359 Bremen, Germany Corresponding author: Maria Shkolnykova E-mail: mariia.shkolnykova@uni-bremen.de 2/41 #2002 Bremen Papers on Economics & Innovation From biotech to bioeconomy New empirical evidence on the technological transition to plant-based bioeconomy based on patent data
Monitoring System for Ubiquitous Healthcare

Ubiquitous computing provides an environment that discretely integrates digital and physical devices, and thus enables users to access data and environment applications as easily as accessing data from their computers. These advances have provided a different perspective on how to work in healthcare. Thus, this paper sets out the project of an ubiquitous system in health that aims to provide information for professionals as well as to have a positive impact on the quality of life. The proposed system allows continuous monitoring of any active signs that people are in need of care, either because they are elderly or suffer from a disease. The architecture allows mobile devices to carry out the collection of data from sensors coupled to the environment or to the individual and make available the information, after it has been processed, by means of web services for use by other applications. What will be examined is the proposed architecture and resources in terms of communication and integration of technologies.
Changes in quality of life after surgery or radiotherapy in early-stage lung cancer.

Background Although surgical resection is considered the standard of care for early-stage non-small cell lung cancer, radiotherapy [stereotactic body radiation therapy (SBRT)] has been proposed as a minimally invasive treatment alternative. Studies have not examined differences in quality of life (QoL) between surgery and radiotherapy, despite important implications for patient and provider decision making. Methods The Surveillance, Epidemiology, and End Results Medicare Health Outcomes Survey (1998-2014) was used to assess changes in physical QoL score [Physical Component Summary (PCS)] and mental health QoL score [Mental Component Summary (MCS)] from baseline (prior to cancer diagnosis) to follow-up after treatment with surgery only or radiotherapy only. QoL was measured using the 36-item Short Form Health Survey (SF-36) until 2006, when it was replaced by the Veterans RAND 12-Item Health Survey (VR-12). Results Data from 184 patients (28 SBRT, 156 surgery) was included. There was a significant decline in PCS score from baseline to follow-up (surgery: -4.81; 95% CI: -6.31, -3.30; P<0.0001; SBRT: -5.6; 95% CI: -9.96, -1.24; P=0.0137). Similarly, MCS scores declined for both groups although the change was significant for surgery patients only (surgery: -2.96; 95% CI: -4.55, -1.37; P=0.0003; SBRT: -1.86; 95% CI: -5.4, 1.68; P=0.2902). Surgical patients had higher baseline PCS (P=0.0061) and MCS (P=0.0056) than SBRT patients. There was no significant difference in the change over time between the two treatment options for PCS or MCS. Conclusions Although both treatments negatively impact QoL, the impact of SBRT on QoL may be comparable to surgery and therefore SBRT should be given consideration as an alternative treatment, especially when surgery is not an option.
Paresthesia‐Free Dorsal Root Ganglion Stimulation: An ACCURATE Study Sub‐Analysis

ACCURATE, a randomized controlled trial comparing dorsal root ganglion (DRG) stimulation to spinal cord stimulation, showed that DRG stimulation is a safe and effective therapy in individuals with lower extremity chronic pain due to complex regional pain syndrome (CRPS) type I or II. Investigators noted that DRG stimulation programming could be adjusted to minimize, or eliminate, the feeling of paresthesia while maintaining adequate pain relief. The present study explores treatment outcomes for DRG subjects who were paresthesia‐free vs. those who experienced the sensation of paresthesia, as well as the factors that predicted paresthesia‐free analgesia.
Non-Pharmacological Pain Management: Nurses’ Knowledge, Attitudes and Practices in selected Hospitals at Makkah El-Mukarramah

Background: Non-pharmacological methods have unique advantages to relieving pain that medications do not have such as giving the patients a more active role in managing their pain. There are many types of nonpharmacological methods that vary amongst heat/cold, distraction, massage and relaxation. Nurses must have a great knowledge of non-pharmacological methods to practice them effectively. In addition, nurses' own attitudes greatly affect the way they treat a patient's pain. This study aimed to evaluate nurses' knowledge, attitudes and practices regarding non-pharmacological pain management in selected hospitals at Makkah El-Mukarmah. Subjects and methods: 120 nurses, males and females working in medical and surgical wards in selected three hospitals at Makkah El-Mukarramah. The data was collected through using a self-administered questionnaire consisting of three parts; a socio-demographic characteristics questionnaire, a nurse's knowledge assessment questionnaire, and a nonpharmacological methods questionnaire. The results show: knowledge and practices were at a satisfactory level. However, the percentage of applied non-pharmacological pain management was low in hospitals because of a lack of time. There was a positive relationship between age, educational level, years of experience, and attendance on training courses with the knowledge and practice and positive relationship between knowledge and practice of the nursing staff regarding non-pharmacological methods. Conclusion: Nurses have a satisfactory level of knowledge and that leads them to have a positive attitude and a high level of efficiency in applying non-pharmacological methods for pain management. Recommendation: This study recommended that efforts to improve application of nondrug interventions should focus on innovative educational strategies, using problem solving to secure support, and development and testing of new delivery methods that require less time from busy staff nurses. [Hanan Said Ali,Youssreya Ibrahim and Esraa Esam Eldin Mohamed. Non-Pharmacological Pain Management: Nurses’ Knowledge, Attitudes and Practices in selected Hospitals at Makkah El-Mukarramah. Life Sci J 2012;9(2s):384-393]. (ISSN:1097-8135). http://www.lifesciencesite. com. 43
Urinary phytate concentration and risk of fracture determined by the FRAX index in a group of postmenopausal women

Background/aim This study was designed to evaluate the relationship between urinary phytate concentration and risk of fracture at 10 years, determined by using the FRAX model, in women who had undergone menopause within 5 years of the time of enrollment. Materials and methods Of the 212 postmenopausal women evaluated, 69 were excluded because they had urinary phytate concentrations between 0.51 and 0.99 mg/L. Of the remaining 143 women, 91 had low (≤0.50 mg/L) and 52 had high (≥1.0 mg/L) urinary phytate concentrations. The 10-year risk of fracture was calculated by using the FRAX model. Results The risks of major osteoporotic fracture and hip fracture were higher in women with low urinary phytate levels (P < 0.001 in both cases). Evaluation of the risk of hip fracture in women with and without risk factors for osteoporosis (e.g., tobacco, alcohol, and drug consumption) and according to urinary phytate concentrations indicated that, among women with no risk factors, those with low and high urinary phytate levels had a range of risks of 0%–0.6% and 0%–0.3%, respectively (P = 0.098). Moreover, among women with at least one risk factor, those with low and high urinary phytate had a range of risks of 0.1%–0.8% and 0.1%–0.4%, respectively (P = 0.002). Similar results were observed when the risks of major osteoporotic fracture were analyzed. Conclusion These results indicate the relationship of phytate with the risks of major osteoporotic fracture and hip fracture, with these differences being more marked in women with risk factors for osteoporosis. From this study follows the importance of the consumption of phytate-rich products (nuts, legumes, whole cereals) to protect against the risk of fracture in 10 years, mainly in women with risk factors for osteoporosis.
An investigation to determine normative anthropometric standards in women of childbearing age ( north-eastern of Iran )

A community based, cross-sectional survey was undertaken on the anthropometric status of Kurmanj, non-pregnant women of childbearing age in the North-eastern of Iran. The main purpose of this investigation was to determine normative anthropometric standards in women of childbearing age. Interviews and anthropometric measurements were completed on 473 non-pregnant women randomly selected and stratified by five year age categories from eight peasant associations. The mean (SD) weight was found to be 46.9(5.3) kg, with 75% weighing less than 50 kg. Women’s height averaged 155.5 cm with nearly 20% under 150 cm. The mean (SD) BMI was 19.4 (1.9) kg/m and 35% of the women had a BMI lower than 18.5 kg/m. Means for all anthropometric measurements fell below the 10th percentile of the standard NCHS reference for women. All anthropometric outcomes were stable across age categories. The relation between these anthropometric measures and adverse health outcomes will require validation. [Esmaeilzadeh M. An investigation to determine normative anthropometric standards in women of childbearing age (north-eastern of Iran). Life Sci J 2012;(2s):147-151] (ISSN:1097-8135). http://www.lifesciencesite. com. 27
Study Role of Coenzyme Q10 in Improvement of Reproduction Efficiency in Female Wister Rats

CoQ10 have the ability to reduce the harmful effect of lead acetate. Therefore, the role of the CoQ10 on the reproductive system of female rats was studied. Gene expression for ovarian estrogen hormone Aromatase cytochrome P450 gene, progesterone (hydroxy-delta5-steroid dehydrogenase, 3 betaand steroid deltaisomerase genes were investigated. cDNA were estimated from 4 group of mature rate that treated with different types of material were (corn oil, CoQ10 lead acetate and lead acetate for30 days then CoQ10). Results showed clear difference in fold change of Aromatase cytochrome P450 and Hydroxy-delta-5steroid dehydrogenase (Hsd3β5 ) expression levels among the groups at level (p<0.05). Gene expression results were revealed that CoQ10 improve the efficiency of reproductive system that exposed to Oxidative stress by lead acetate
Different Inhibitory Interneuron Cell Classes Make Distinct Contributions to Visual Contrast Perception

Abstract While recent work has revealed how different inhibitory interneurons influence responses of cortical neurons to sensory stimuli, little is known about their distinct contributions to sensory perception. Here, we optogenetically activated different genetically defined interneurons [parvalbumin (PV), somatostatin (SST), vasoactive intestinal peptide (VIP)] in visual cortex (V1) of mice working at threshold in a contrast increment detection task. The visual stimulus was paired with optogenetic stimulation to assess how enhancing V1 inhibitory neuron activity during visual processing altered task performance. PV or SST activation impaired, while VIP stimulation improved, contrast increment detection. The impairment produced by PV or SST activation persisted over several weeks of testing. In contrast, mice learned to reliably detect VIP activation in the absence of any natural visual stimulus. Thus, different inhibitory signals make distinct contributions to visual contrast perception.
Journal of the Meteorological Society of Japan, Vol. 82, No. 4, pp. 1223--1231, 2004

Using satellite-derived daily sea ice motion, this paper presents maps showing the relationship between the ice motion and surface wind, and mean ocean current in the Southern Ocean. The daily ice motions were derived from Defense Meteorological Satellite Program (DMSP) Special Sensor Microwave Imager (SSM/I) images. The mean ice motion field is characterized by eastward circumpolar drift; northward drifts in the Weddell Sea, Ross Sea, and areas around 80 E; and narrow westward coastal currents. A linear formula is used to examine the relationship between the ice motion and wind. It was found that daily variation in the ice motion is closely correlated with wind speed fluctuation, and that features of mean ice motion are mainly attributable to atmospheric forcing. The speed reduction factor (ratio of ice speed to wind speed) is relatively small near the coast, and increases with distance from the coast. Surface ocean currents beneath the ice cover were derived by subtracting the wind effect from the ice motion. It is revealed that the ocean current field is associated with the bottom topography.
Pulmonary Fibrosis among World Trade Center Responders: Results from the WTC Health Registry Cohort

Dust created by the collapse of the World Trade Center (WTC) towers on 9/11 included metals and toxicants that have been linked to an increased risk of pulmonary fibrosis (PF) in the literature. Little has been reported on PF among WTC responders. This report used self-reported physician diagnosis of PF with an unknown sub-type to explore the association between levels of WTC dust exposure and PF. We included 19,300 WTC responders, enrolled in the WTC Health Registry in 2003–2004, who were followed for 11 years from 2004 to 2015. Exposure was defined primarily by intensity and duration of exposure to WTC dust/debris and work on the debris pile. Stratified Cox regression was used to assess the association. We observed 73 self-reported physician-diagnosed PF cases, with a PF incidence rate of 36.7/100,000 person-years. The adjusted hazard ratio (AHR) of PF was higher in those with a medium (AHR = 2.5, 95% CI = 1.1–5.8) and very high level of exposure (AHR = 4.5, 95% CI = 2.0–10.4), compared to those with low exposure. A test for exposure—response trend was statistically significant (Ptrend = 0.004). Future research on WTC dust exposure and PF would benefit from using data from multiple WTC Health Program responder cohorts for increased statistical power and clinically confirmed cases.