Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic Significance of the Hsp70 Gene Family in Colorectal Cancer

Background Colorectal cancer (CRC) is a deadly form of cancer worldwide. Heat shock protein 70 (Hsp70) belongs to the family of human HSPs and plays an essential role in multiple cellular developments and in responding to environmental changes. However, studies on the relationship between CRC and the Hsp70 family are rare. Material/Methods Data pertaining to 438 patients with CRC was downloaded from The Cancer Genome Atlas database. To investigate the prognostic significance of the Hsp70 genes, survival and joint-effect analyses were conducted. The correlation between prognosis-related Hsp70 genes and clinical factors in CRC was analyzed using a nomogram. Gene set enrichment analysis (GSEA) was performed to explore the complex enrichment pathway in CRC with the prognosis-related Hsp70 genes. Results According to multivariate Cox regression survival analysis, low expression levels of HSPA1A, HSPA1B, and HSPA1L were correlated with improved overall survival (OS). According to the joint-effects survival analysis, the joint low expression levels of HSPA1A, HSPA1B, and HSPA1L were related to improved OS. The 1-, 3-, 5-, and 10-year survival rates of patients with CRC were predicted by constructing a nomogram model based on HSPA1A, HSPA1B, HSPA1L, and tumor stage. The GSEA results indicated the biological roles of HSPA1A, HSPA1B, and HSPA1L in CRC. Conclusions Low expression levels of HSPA1A, HSPA1B, and HSPA1L were strongly correlated with improved prognosis in CRC and might serve as latent prognostic biomarkers in CRC.
Modelling the Interaction of Liquidity to Price Dynamics

This paper studies the impact of financial liquidity on the macro-economy. We extend a classic macroeconomic model and compute numerical simulations. The model confirms that persistently low inflation can occur despite a high degree of financial liquidity due to a reallocation of cash, normal and risk-free bonds. In that regard, our model uncovers an explanation of a flat Phillips curve. Overall, our approach contributes to a rather disregarded matter in macroeconomic theory. I would like to thank all conference participants and my research assistant Adrián Elsässer Briones for commenting a preliminary version of this paper. I thank the anonymous reviewers for good comments. All remaining errors are my own responsibility. Address: Reutlingen University and Reutlingen Research Institute (RRI). Email: Bodo.Herzog@Reutlingen-University.de Citation: Bodo Herzog, (2020) ''Modelling the Interaction of Liquidity to Price Dynamics'', Economics Bulletin, Volume 40, Issue 2, pages 1420-1430 Contact: Bodo Herzog Bodo.Herzog@Reutlingen-University.de. Submitted: February 29, 2020. Published: June 02, 2020.
The time-varying networks of the wrist extension in post-stroke hemiplegic 1 patients 2 3

14 Background: Hemiplegia is a common dysfunction caused by a stroke and leads to 15 movement disability. Although the movement-related oscillation, the lateralization of 16 the movement-related potential, and the event-related desynchronization have been 17 investigated, the dynamic network modalities related to the movements in post-stroke 18 hemiplegic patients are still left unveiled. 19 Methods: In our present study, we designed the motor execution task of the wrist 20 extension, collected the movement-related electroencephalograms, and adopted the 21
Quality of Life, Social Support and Religiosity of Brazilian Patients Diagnosed with Multiple Myeloma by a Public Institution

Purpose: To assess the quality of life, social and religious indicators of patients diagnosed with multiple myeloma (MM) and correlate them with sociodemographic and clinical characteristics. Methods: Cross-sectional study, with all outpatients diagnosed with MM (N: 23), in a 12-month period, in a public hospital in the city of São Paulo, Brazil. Data collection instruments: sociodemographic and clinical assessment; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire; Social Support Scale of Medical Outcomes Study; Instrument Religiosity Index from Duke University. Results: The quality of life was worst rated for physical (44.1; 95%CI 32.0–56.0) and role performance (41.3; 95%CI 24.0–58.6) and best rated for cognitive function (69.6; 95%CI 58.4–80.8). The emotional support was higher in affective domains (91; 95%CI 85.1–96.9) and in material domains (90.9; 95%CI 84.0–97). The intrinsic religiosity dimension obtained a high score (9.74; 95%CI 8.6–10.9). The older patients showed worse quality of life in emotional function (p=0.003) due to financial difficulties (p=0.009). Individuals from lower economic classes (C2 and D) reported worse quality of life in cognitive function (p=0.04). Men showed higher total emotional support scores (p=0.02), while women showed worse quality of life due to financial difficulties (p=0.04). Married patients reported greater total emotional support (p<0.001). Conclusion: The quality of life was worse among older patients, the ones with lower purchasing power and women. The social support and the religiosity index were high, in general.
Influence of Stress and Defect on Magnetic Properties of Mn3O4 Films Grown on MgAl2O4 (001) by Molecular Beam Epitaxy

Three single-crystal Mn3O4 thin films were grown on MgAl2O4 (001) substrates by plasma-assisted molecular beam epitaxy (PA-MBE). The films with different thicknesses are found to be compressed in the (001) plane and elongated in the perpendicular direction at different levels via in situ reflection high-energy electron diffraction (RHEED) and ex situ X-ray diffraction. Magnetic measurements indicate that either of the two thicker films owns smaller spontaneous magnetization, larger coercive force, and higher phase transition temperature than the bulk single-crystal Mn3O4 material. On the contrary, it is noteworthy that the thinnest film exerts different characteristics with smaller coercive force and lower phase transition temperature than the bulk. The variation of magnetic properties for the films are proposed to be related to the combined effects of the lattice distortion under epitaxial stress, strain relaxation with the generation of defects and dislocations, and surface roughness, which could influe.
A Concise Overview of Chemotherapeutic Drugs in Gastrointestinal Cancers: Mechanisms of Action and Resistance

Gastrointestinal (GI) cancers are malignancies of the gastrointestinal tract and accessory organs of the digestive system including the esophagus, pancreas, stomach, colon, rectum, anus, liver, gallbladder, biliary system, and small intestine. These account for 28% of global cancer incidence and 35% of cancer-related mortalities. The most common type of GI cancers: colorectal and gastric cancers, rank among the top five cancers. Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy are available options for GI cancer treatment. With surgery being the first-line of choice, pre or post-operative chemotherapy is the second most-often used. Nevertheless, the long-term survival rate in GI cancer patients is modest due to the development of drug resistance, which can be overcome by administering various combinations of chemotherapeutic and targeted therapeutic drugs. The classic example is fluoropyrimidine, a class of cytotoxic drug used in combination with irinotecan, gemcitabine, and docetaxel to increase overall and progression-free survival in colorectal, pancreatic, and gastric cancers, respectively. Although in-depth expert reviews on select chemotherapies for the most common GI cancer types can be found, a concise overview of different drugs approved for all GI cancers is not available. In this review, we have compiled a list of the most common chemotherapeutic drugs used for GI cancers and summarized their major modes of action, intrinsic/adaptive resistance, and a few pre-clinical/clinical approaches to overcoming such resistance. We hope this manuscript will be useful for non-expert readers interested in a general overview of GI cancer chemotherapies.
Status and Ecology of Mexican Spotted Owls in the Gila Region, New Mexico

The highlands of New Mexico’s Gila region provide an important stronghold for the Mexican spotted owl (Strix occidentalis lucida Nelson). Historical data document that this region supported spotted owls in the past, and recent studies indicate that owls are both relatively common and well distributed in this region at present. Spotted owls are most numerous in mixed-conifer forests within the Gila region but may also occur in other forest types, particularly where rocky cliffs and outcrops are present. These features provide owls with nest and roost sites as well as habitat for common prey species. Spotted owl diets in the region typically are dominated by a few types of nocturnally active small mammals. The Gila region features a convergence of topography, geologic substrates, and forest types that provide suitable habitat for Mexican spotted owls and their prey, and contains large roadless areas that result in minimal disturbance due to land management. These large roadless areas also provide unique opportunities to manage wildfire at landscape scales, thus providing an opportunity to evaluate relationships between spotted owls, forest habitats, and fire. Despite their abundance and widespread distribution in the region, however, studies between 1990 and 2005 suggest that some local owl populations may be declining in the region. This is a concern because the Gila region likely serves as an important source population of spotted owls. Uncertainty over population trends suggests a need for continued monitoring of owl populations in this region.
Machine Translation in Medicine A quality analysis of statistical machine translation in the medical domain

—Machine translation is evolving quite rapidly in terms of quality. Nowadays, we have several machine translation systems available in the web, which provide reasonable translations. However, these systems are not perfect, and their quality may decrease in some specific domains. This paper presents an analysis and evaluation of the quality of a state-of-the-art machine translation system in the medical domain. Evaluation is performed automatically and manually for seven language pairs. Results show that for most of them, machine translation is not ready to be applied in a domain like medicine where a translation with 100% adequacy is required.
Retrospective evaluation of the patterns of clinical use of anti-parasitic agents on animals presented for veterinary care at an animal hospital in Nigeria

Patterns of use of anti-parasitic agents (APAs) on animals presented for veterinary care at the Veterinary Teaching Hospital, Nsukka, Nigeria, from January 2013 to December 2017 were surveyed. Animals presented were predominantly dogs (84.0%) and goats (8.1%). A total of 4851 cases were evaluated, out of which 3196 (65.9%) were treated with APAs. There was a significant variation (p=0.002) in the annual frequency of use of APAs across the study period, but the effect size of the variation was small (ɸc=0.06). Ivermectin was the most frequently used APA (1479 out of the 3196 = 46.3%); followed by praziquantel-pyrantel-fenbendazole combined formulation (PPFCF) (1231 out of the 3196 = 38.5%), pyrantel pamoate (848 out of the 3196 = 26.5%) and benzimidazoles (477 out of the 3196 = 14.9%). The frequencies of use of others were below 10%. There were significant variations (p<0.01) in the frequency of use of all the APAs across the study period, but the effect size of the variations ranged from small for amitraz (ɸc=0.08; p=0.001), amprolium-sulphaquinoxaline combination (ASC) [ɸc=0.07; p=0.006] and fipronil (ɸc=0.09; p=0.000), to moderate for benzimidazoles (ɸc=0.12; p=0.000), diminazene aceturate (ɸc=0.11; p=0.000), ivermectin (ɸc=0.11; p=0.000) and pyrantel pamoate (ɸc=0.10; p=0.000), and large for cypermethrin (ɸc=0.15; p=0.000), levamisole (ɸc=0.15; p=0.000), metronidazole (ɸc=0.24; p=0.000), PPCFC (ɸc=0.18; p=0.000) and pyrethrin powder (ɸc=0.27; p=0.000). Out of the 3196 cases in which APAs were used, there were inappropriate use in 8.9% of cases, non-compliance in 44.0%, use of APAs without definitive diagnosis in 46.8%, and wrong combinations in 8.8%. The frequencies of misuse of the APAs varied significantly (p=0.000) across the study period, and the effect size was moderate for inappropriate use (ɸc=0.13; p=0.000), non-compliance (ɸc=0.14; p=0.000) and wrong combinations (ɸc=0.10; p=0.000), but large for the use of APAs without definitive diagnosis (ɸc=0.23; p=0.000). It was concluded that the overall frequency of use of APAs in the study population was high during the study period, with significant variations in the frequency and effect size of the specific APAs, and their misuse.
Synthesis of goethite in solutions of artificial seawater and amino acids: a prebiotic chemistry study

Abstract This study investigated the synthesis of goethite under conditions resembling those of the prebiotic Earth. The artificial seawater used contains all the major elements as well as amino acids (α-Ala, β-Ala, Gly, Cys, AIB) that could be found on the prebiotic Earth. The spectroscopic methods (FT-IR, EPR, Raman), scanning electron microscopy (SEM) and X-ray diffraction showed that in any condition Gly and Cys favoured the formation of goethite, artificial seawater plus β-Ala and distilled water plus AIB favoured the formation of hematite and for the other synthesis a mixture of goethite and hematite were obtained. Thus in general no protein amino acids (β-Ala, AIB) favoured the formation of hematite. As shown by surface enhanced Raman spectroscopy (SERS) spectra the interaction between Cys and Fe3+ of goethite is very complex, involving decomposition of Cys producing sulphur, as well as interaction of carboxylic group with Fe3+. SERS spectra also showed that amino/CN and C-CH3 groups of α-Ala are interacting with Fe3+ of goethite. For the other samples the shifting of several bands was observed. However, it was not possible to say which amino acid groups are interacting with Fe3+. The pH at point of zero charge of goethites increased with artificial seawater and decreased with amino acids. SEM images showed when only goethite was synthesized the images of the samples were acicular and when only hematite was synthesized the images of the samples were spherical. SEM images for the synthesis of goethite with Cys were spherical crystal aggregates with radiating acicular crystals. The highest resonance line intensities were obtained for the samples where only hematite was obtained. Electron paramagnetic resonance (EPR) and Mössbauer spectra showed for the synthesis of goethite with artificial seawater an isomorphic substitution of iron by seawater cations. Mössbauer spectra also showed that for the synthesis goethite in distilled water plus Gly only goethite was synthesized and in artificial seawater plus Cys a doublet due to interaction of iron with artificial seawater/Cys was observed. It should be pointed out that EPR spectroscopy did not show the interaction of iron with artificial seawater/Cys.
PROBABILÍSTICO DO SEXO (DSP V2) EM UMA POPULAÇÃO DO SUDESTE BRASILEIRO APPLICATION AND VALIDATION OF DIAGNOSE SEXUELLE PROBABILISTE V2 TOOL IN A SOUTHEASTERN BRAZILIAN POPULATION

The hip bone (os coxae) is the skeletal element that presents the greatest level of sexual dimorphism. Therefore, methods involving the analysis of the os coxae provide the most accurate sex estimation, and DSP2 (Diagnose Sexuelle Probabiliste v.2) is one of the most accurate tools used in this identification. The aim of this study was to apply and validate DSP2 in the identification of 103 os coxae (53 male and 50 female) belonging to a Brazilianidentified skeletal collection. A sample of 103 hip bones (53 male and 50 female) belonging to the osteological collection of the Forensic Dentistry area of the School of Dentistry of Piracicaba UNICAMP was measured according to the instructions of the DSP2 tool. The collection consists of recent and modern cataloged bones, compiled from individuals who died between 2008 and 2010 of a population of southeastern Brazil. The mean age of the subjects was 55 years. Measurements were performed with a 150-mm digital caliper (Starrett, Athol, Massachusetts, USA) and with a 600-mm caliper for regions where the digital caliper did not allow reaching. Calibrations were performed by two forensic experts, with double blindness. Only the left hip bones were evaluated. The data acquisition was obtained in two steps: a) metric analysis by the DSP2 method; b) comparison between the estimation of sex by DSP2 and the information present in the cataloged osteological collection. The analysis of the measurement errors was made through three indicators frequently used in osteometric and anthropometric studies. The technical error of measurement (TEM), the relative technical error (% TEM) and the reliability coefficient (R) were calculated to evaluate the accuracy and reliability of the measurements. The results were expressed as mean and standard deviation. Statistical analyzes were performed using the Bioestat ® (Mamirauá Institute Conservation in the Amazon, Brazil). For each sample, the assumption of univariate normality was verified by the Kolmogorov-Smirnov test. The differences in statistical significance between men and women for each measurement were evaluated using the t-test of unpaired samples. The level of significance was set at p <0.05. Differences between sexes were statistically significant for all measurements, except for the acetabulo-symphyseal and spino-auricular lengths. From the 103 os coxae analyzed, there was a 9.43% error in male individuals and a 14% error in females. The results revealed that DSP2 can be applied to Brazilian-mixed populations with a good index of accuracy, although at a lower accuracy than other population samples. This study also clearly demonstrates that metric variation of the os coxae is extremely useful in sex estimation and reinforces the notion that pelvic sexual dimorphism is not population-specific.
Artificial microRNA-Based RNA Interference and Specific Gene Silencing for Developing Insect Resistance in Solanum lycopersicum

RNA Interference (RNAi), which works against invading nucleic acids or modulates the expression of endogenous genes, is a natural eukaryotic regulating system, and it works by noncoding smaller RNA molecules. Plant-mediated gene silencing through RNAi can be used to develop plants with insect tolerance at transcriptional or post-transcriptional levels. In this study, we selected Myzus persicae’s acetylcholinesterase 1 gene (Ace 1) as a silencing target to develop transgenic Solanum lycopersicum L. plants’ resistance to aphids. An RNAi plasmid vector containing an artificial microRNA (amiRNA) sequence was engineered and successfully transformed into Jamila and Tomaland, two elite tomato cultivars. A northern blot analysis and PCR were carried out to check the efficacy of Agrobacterium-mediated transformation in T0 transgenic plants. The quantitative PCR data showed a substantial downregulation of the Ace 1 gene in aphids fed in clip cages on T1 transgenic plants. Furthermore, there was a substantial drop in aphid colonies that were fed on T1 transgenic plants of both the cultivars. These findings strongly suggest that transgenic plants that express amiRNA could be an important tool for engineering plants resistant to aphids and possibly for the prevention of viral disease in other plant-infested pests.
A Pilot Study with Randomised Controlled Design Comparing TiZr Alloy Dental Implants to Ti Implants

ABSTRACT Objectives Evidence on the clinical performance of recently introduced dental implants in titanium-zirconium alloy is sparse. The aim of the present pilot study with randomized controlled design is to compare changes in supporting structures around dental titanium-zirconium alloy implants to commercially pure titanium implants. Material and Methods The present material includes consecutive patients referred to a specialist clinic in Sweden. Two patient groups treated with dental implants in two different materials - titanium (Ti) and titanium-zirconium (TiZr) - were defined after block randomisation for smoking. In total, 40 implants installed in 21 patients were available for one-year follow-up. Marginal bone level, soft tissue height and width of keratinised mucosa were registered at baseline and at one-year follow-up. Results At implant level, the test group (TiZr) yielded significant marginal bone loss (P < 0.001) after one year. Additionally, marginal bone loss after one year was significantly higher for TiZr implants (P < 0.001) as compared to traditional Ti implants. Soft tissue dimensions were stable throughout the evaluation time for both implant materials. Conclusions One-year results indicate more pronounced initial marginal bone loss for dental implants in titanium-zirconium alloy as compared to implants made of commercially pure titanium.
Trends of Hydro-Meteorological Indices in Tendaho Catchment Part of Awash River Basin, Ethiopia

The variability in the intensity and frequency of extreme hydrometeorological events due to climate change have an enormous impact in managing water resources in developing countries. Frequently it has been recognized sudden droughts and a severe floods. This study analyzed the spatial and temporal trends of five meteorology indices: annual maximum precipitation (AMP),annual precipitation (AP), mean areal precipitation (MAP),annual maximum temperature (AMaT) and annual minimum temperature (AMiT) and three stream flow indices: mean annual flow(MAF), annual maximum flow (AMaxF) and total mean annual flow (TMAF) over the Tendaho Catchment. Mann-Kendall (MK), Spearman Rho (SR), Sen’s slope test in R-program modifiedmk package and Sen innovative trend test were used to detect trends of 16 meteorological and one stream flow stations from 1979-2017. The result showed that there is a statistically significant temporal trends only in AMP, AP, AMaT and AMiT at 6, 19, 56 and 50% of the stations respectively. The remaining indices have no statistically significant trend in all the stations. It also dictates that the catchment is characterized by a slightly increasing AP and AMP; a slightly decreasing MAP and a significant increasing AMaT and AMiT trends. Except AMaT, there is no particular spatial pattern of AP, MAP and AMiT on the majority of the stations. Whereas, all stream flow indices showed a slightly decreasing temporal trend at 95% confidence. From this, we can conclude that the decreasing flow trend could be due to the decrement of MAP, an increment of temperature and construction of reservoirs in the catchment.
Cost Effective Media Optimization for the Enhanced Production of Hyaluronic Acid Using a Mutant Strain Streptococcus zooepidemicus 3523-7: A Statistical Approach

The hydrated gel hyaluronic acid (HA) comprises repeating units of glucuronic acid and N-acetylglucosamine. HA production has a lot of significance in the present day scenario owing to its clinical applications. Fermentative optimization is carried out in two steps. Statistical optimization of media components for the production of HA using Taguchi and Response Surface Methodology (RSM) was studied using a mutant strain Streptococcus zooepidemicus 3523-7. Initial optimization was carried out using L27 orthogonal array. The significance of each factor with respect to HA production was identified using Taguchi design (Glucose, Yeast extract, K2HPO4, NaH2PO4, NaCl, NH4Cl, 1M MgSO4 and Trace metal mix (TMM)) and the productivity was increased 1.34 folds (738 to 988 mg/L) over native production medium. The outcome of Taguchi results indicates the glucose, yeast extract, K2HPO4 and NH4Cl are most influencing factors in the production of HA. Final optimization was carried out using RSM (Central Composite Rotatable Design) and the production was significantly enhanced to 1.4 folds (988 to 1386 mg/L). For the first time statistical optimization was carried out using a mutant strain Streptococcus zooepidemicus 3523-7 and high yield (1386 mg/L) of HA was achieved.