Miracle-dz/UniFAR-FTUs huggingface dataset:
Blood Test Results of Pregnant COVID-19 Patients: An Updated Case-Control Study

Background: Coronavirus disease (COVID-19) is a current global public health emergency. However, current research on the blood test results of pregnant women with COVID-19 is insufficient. Methods: A case-control study was carried out based on clinical blood test results. Pregnant COVID-19 patients, pregnant COVID-19 patients with diabetes, and pregnant COVID-19 patients with hypertension, were assessed in this study. Also, 120 controls were matched by age, parity, fetus number, and presence of chronic disease. T-tests, Chi-square tests, Wilcoxon signed-rank tests, and Kruskal-Wallis tests were used to compare data from the blood tests and liver function indices among the selected groups. Results: Between January 24 and March 14, 2020, 60 pregnant COVID-19 patients delivered at the Maternal and Child Health Hospital of Hubei Province. The average maternal age of pregnant COVID-19 patients was 30.97 years and the mean gestational period was 37.87 weeks. 71.67% (43/60) of pregnant COVID-19 patients gave birth by cesarean delivery. In total, 21.67% (13/60) were diagnosed with diabetes and 18.33% (11/60) were diagnosed with hypertension during pregnancy. Compared to controls, pregnant COVID-19 patients showed significantly lower numbers of blood lymphocytes and higher numbers of neutrophils, as well as higher levels of C-reactive protein and total bilirubin. Among the three groups, pregnant COVID-19 patients with diabetes had significantly higher levels of neutrophils and lower levels of total protein. Aspartate transaminase levels were higher in pregnant COVID-19 patients with hypertension than in pregnant COVID-19 patients with no comorbidities and controls with hypertension. Interpretations: Blood and liver function indices indicate that chronic complications, including hypertension and diabetes, could increase the risk of inflammation and liver injury in pregnant COVID-19 patients.
REVISION OF TRICHODERMA SECT. LONGIBRACHIATUM INCLUDING RELATED TELEOMORPHS BASED ON ANALYSIS OF RIBOSOMAL DNA INTERNAL TRANSCRIBED SPACER SEQUENCES

Variation within the internal transcribed spacer (ITS-1 and ITS-2) regions of ribosomal DNA of 103 strains was studied to examine relationships within Trichoderma sect. Longibrachiatum and related teleomorphs, Hypocrea schweinitzii and H. jecorina. The four species, T longibrachiatum, T. pseudokon- ingii, T parceramosum and T citrinoviride, that were originally assigned by morphological criteria to this section were recognized by sequence analysis. Trich- oderma reesei, which was previously considered to be synonymous with T longibrachiatum, and T saturnis- porum which was placed originally in sect. Saturnis- porum because of its warted conidia, are assigned to the section. ITS sequences of T ghanense, originally assigned to sect. Saturnisporum, could not be distin- guished from the sequence of T parceramosum, in- dicating that the two may be synonymous. Trichoder- ma "todica", an unpublished name based on the an-
Length-weight and length-length relationships of seven loach species (Teleostei: Cypriniformes) from five localities in northern Western Ghats, India

Length-weight (LWR) and length-length (LLR) relationships of seven loach species (Teleostei: Cypriniformes): Botia striata, Lepidocephalichthys thermalis, Paracanthocobitis mooreh, Indoreonectes evezardi, Nemacheilus anguilla, Nemachilichthys rueppelli and Schistura denisoni were studied from five localities within the Krishna River system of the Indian Western Ghats: Lonawala (Indrayani River), Paud (Mula River), Warje (Mutha River), Bhor (Nira River) and Patan (Koyna River). With the exception of L. thermalis all species are endemic to peninsular India, and to our knowledge this is the first presentation of LWR and LLR data for them. New maximum lengths are also reported for I. evezardi, N. anguilla, N. rueppelli and S. denisoni.
A Comparison of Social Robot to Tablet and Teacher in a New Script Learning Context

This research occurred in a special context where Kazakhstan's recent decision to switch from Cyrillic to the Latin-based alphabet has resulted in challenges connected to teaching literacy, addressing a rare combination of research hypotheses and technical objectives about language learning. Teachers are not necessarily trained to teach the new alphabet, and this could result in a challenge for children with learning difficulties. Prior research studies in Human-Robot Interaction (HRI) have proposed the use of a robot to teach handwriting to children (Hood et al., 2015; Lemaignan et al., 2016). Drawing on the Kazakhstani case, our study takes an interdisciplinary approach by bringing together smart solutions from robotics, computer vision areas, and educational frameworks, language, and cognitive studies that will benefit diverse groups of stakeholders. In this study, a human-robot interaction application is designed to help primary school children learn both a newly-adopted script and also its handwriting system. The setup involved an experiment with 62 children between the ages of 7–9 years old, across three conditions: a robot and a tablet, a tablet only, and a teacher. Based on the paradigm—learning by teaching—the study showed that children improved their knowledge of the Latin script by interacting with a robot. Findings reported that children gained similar knowledge of a new script in all three conditions without gender effect. In addition, children's likeability ratings and positive mood change scores demonstrate significant benefits favoring the robot over a traditional teacher and tablet only approaches.
β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood–Brain Barrier Opening in Alzheimer’s Disease

The blood–brain barrier (BBB) limits therapeutic delivery in Alzheimer’s disease (AD) and other neurological disorders. Animal models have demonstrated safe BBB opening and reduction in β-amyloid plaque with focused ultrasound (FUS). We recently demonstrated the feasibility, safety, and reversibility of FUS-induced BBB opening in the hippocampus and entorhinal cortex in six participants with early AD. We now report the effect of BBB opening with FUS treatment on β-amyloid plaque. Six participants underwent 18F-Florbetaben PET scan at baseline and 1 week after the completion of the third FUS treatment (60 days interval). PET analysis comparing the hippocampus and entorhinal cortex in the treated and untreated hemispheres revealed a decrease in the ratio of 18F-Florbetaben ligand binding. The standard uptake value ratios (SUVr) reduction ranged from 2.7% to 10% with an average of 5.05% (±2.76) suggesting a decrease in β-amyloid plaque.
A model for planktic foraminiferal shell growth

In this paper we analyze the laws of growth that control planktic foraminiferal shell morphology. We assume that isometry is the key toward the understanding of their ontogeny. Hence, our null hypothesis is that these organisms construct isometric shells. To test this hypothesis, geometric models of their shells have been generated with a personal computer. It is demonstrated that early chambers in log-spirally coiled structures cannot follow a strict isometric arrangement. In the real world, the centers of juvenile chambers deviate from the logarithmic growth curve. Juvenile stages are generally more planispiral and contain more chambers per whorl than adult stages. These traits are shown to be essential in order to keep volumes of consecutive chambers in geometric progression. We are convinced that the neanic stage marks the constructional bridge from a juvenile set of growth parameters to an adult one. The adult stage can be strictly isometric, that is, the effective shape is constant and the increase in volume after a chamber addition is proportional to the preexisting volume of the shell. The shell volume is related to the biomass, the ratio of outer shell surface area to shell volume is related to the respiration rate and the ratio of the total shell surface area to shell volume is related to the total calcification effort. The influence of the parameters of the model on these relationships is investigated. Only the initial radius and the rate of radius increase affect the relationships between shell volume and surface area. The other shape parameters merely provide a fine tune-up of these relationships. Size itself plays a major role during foraminiferal development.
Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders

Neurodegenerative disorders such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) suffer from the lack of risk-predictive circulating biomarkers, and clinical diagnosis occurs only when symptoms are evident. Among potential biomarkers, platelet parameters have been associated with both disorders. However, these associations have been scarcely investigated at the genetic level. Here, we tested genome-wide coheritability based on common genetic variants between platelet parameters and PD/AD risk, through Linkage Disequilibrium Score Regression. This revealed a significant genetic correlation between platelet distribution width (PDW), an index of platelet size variability, and PD risk (rg [SE] = 0.080 [0.034]; p = 0.019), which was confirmed by a summary-summary polygenic score analysis, where PDW explained a small but significant proportion PD risk (<1%). AD risk showed no significant correlations, although a negative trend was observed with PDW (rg [SE] =-0.088 [0.053]; p=0.096), in line with previous epidemiological reports. These findings suggest the existence of limited shared genetic bases between PDW and PD and warrant further investigations to clarify the genes involved in this relation. Additionally, they suggest that the association between platelet parameters and AD risk is more environmental in nature, prompting an investigation into which factors may influence these traits.
Breeders are less active foragers than non-breeders in wild Damaraland mole-rats

Eusocial societies are characterized by a clear division of labour between non-breeding workers and breeding queens, and queens often do not contribute to foraging, defence and other maintenance tasks. It has been suggested that the structure and organization of social mole-rat groups resembles that of eusocial insect societies. However, the division of labour has rarely been investigated in wild mole-rats, and it is unknown whether breeders show decreased foraging activity compared with non-breeding helpers in natural groups. Here, we show that, in wild Damaraland mole-rats (Fukomys damarensis), breeders show lower activity in foraging areas than non-breeding group members. Both breeders and non-breeders displayed variation in activity across the different seasons. Our results suggest that group living allows social mole-rat breeders to reduce their investment in energetically costly behaviour, or alternatively, that the high cost of reproduction in this species forces a behavioural trade-off against foraging investment.
Performance of Distress Thermometer and Associated Factors of Psychological Distress among Chinese Cancer Patients

Objective We aimed to examine the performance of the distress thermometer (DT) and identify the prevalence and risk factors associated with psychological distress (PD) in heterogeneous cancer patients. Methods This cross-sectional study enrolled 1496 heterogeneous cancer patients from the inpatient and outpatient departments. Receiver operating characteristic analysis (ROC) of DT was evaluated against the Hospital Anxiety and Depression Scale-Total (HADS-T ≥15). An area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and clinical utility index were calculated. Multiple binary logistic regression was used to identify the factors associated with PD. Results Referring to ROC analysis, DT showed good discriminating accuracy (AUC = 0.88). A cutoff score of 4 was established, and it yielded sensitivity (0.81), specificity (0.88), PPV (0.87), NPV (0.82), and clinical utility indexes (screening utility = 0.71 and case-finding utility = 0.73). 46.5% of our participants was distressed. Lower education levels (odd ratio (OR) = 1.39), advanced stage (OR = 1.85), active disease status (OR = 1.82), lack of exercise (OR = 3.03), diagnosis known (OR = 0.64), emotional problems (OR = 3.54), and physical problems (OR = 8.62) were the predictive factors for PD. Conclusion DT with a cutoff score (≥4) is a comprehensive, appropriate, and practical initial screener for PD in cancer patients. Predicting factors should be considered together for effective management of PD in such population.
Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung

LAMP2A and HSC70 are crucial players in chaperone-mediated autophagy (CMA), a targeted, lysosome-dependent protein degradation pathway. Elevated LAMP2A levels, indicative of increased CMA activity, are observed in several malignancies, and CMA downregulation may be exploited therapeutically. We evaluated the impact of LAMP2A and HSC70 in pulmonary squamous cell carcinomas (pSQCC). Antibodies were validated by knockdown and overexpression experiments using three different cell lines. Expression levels in tissue were analyzed by immunohistochemistry in a cohort of 336 consecutive pSQCC using tissue microarrays. There was no significant correlation between the two markers among each other and no association with pathological parameters (TNM categories, grading). However, both high LAMP2A and HSC70 expression were associated with worse outcome, including overall survival (OS; p = 0.012 and p = 0.001) and disease free survival (DFS; p = 0.049 and p = 0.036). In multivariate analysis, both markers and a combination of them were independent adverse prognostic factors for OS (LAMP2Ahigh: HR = 2.059; p < 0.001; HSC70high: HR = 1.987; p < 0.001; LAMP2Ahigh/HSC70high: HR = 1.529; p < 0.001) and DFS (LAMP2Ahigh: HR = 1.709; p = 0.004; HSC70high: HR = 1.484; p = 0.027; LAMP2Ahigh/HSC70high: HR = 1.342, p < 0.001). The negative prognostic impact of high LAMP2A and HSC70 and their variable expression in pSQCC may justify the use of these proteins as potential biomarkers for future CMA-inhibiting therapies.
Complementing or conflicting? How pharmacists and physicians position the community pharmacist

Background: Interprofessional collaboration between pharmacists and physicians in primary care has been linked to improved patient outcomes. How professionals position themselves and each other can shed light upon their relationship, and positioning theory can be used as a tool to better understand intergroup relations. Objectives: 1) To identify how community pharmacists position themselves, and how they are positioned by general practitioners. 2) To assess how well these positions correspond, how the positions align with a proactive position for the pharmacists, and discuss how the positions could potentially impact collaboration. Methods: In this qualitative study, data were collected through six focus group interviews held between June and October 2019, three with pharmacists and three with physicians. The focus group interviews were conducted using a semi-structured interview guide. Data were audio recorded, transcribed verbatim, and analyzed using the Systematic text condensation method. Positioning theory was used as a theoretical framework to identify the positions assigned to community pharmacists by the pharmacists themselves and by the physicians. Results: Twelve pharmacists and ten physicians participated. The pharmacists positioned themselves as the “last line of defense”, “bridge-builders”, “outsiders” – with responsibility, but with a lack of information and authority – and “practical problem solvers”. The physicians positioned pharmacists as “a useful checkpoint”, “non-clinicians” and “unknown”. Conclusions: The study revealed both commonalities and disagreements in how community pharmacists position themselves and are positioned by general practitioners. Few of the positions assigned to pharmacists by the physicians support an active role for the pharmacists, while the pharmacists´ positioning of themselves is more diverse. The physicians´ positioning of pharmacists as an unknown group represents a major challenge for collaboration. Increasing the two professions´ knowledge of each other may help produce new positions that are more coordinated, and thus more supportive towards collaboration.
Searching for shocks in high-mass starless clump candidates

In order to search for shocks in the very early stage of star formation, we performed single-point surveys of SiO J=1-0, 2-1 and 3-2 lines and the H$_2$CO $2_{12}-1_{11}$ line toward a sample of 100 high-mass starless clump candidates (SCCs) by using the Korean VLBI Network (KVN) 21-m radio telescopes. The detection rates of the SiO J=1-0, 2-1, 3-2 lines and the H$_2$CO line are $31.0\%$, $31.0\%$, $19.5\%$ and $93.0\%$, respectively. Shocks seem to be common in this stage of massive star formation. The widths of the observed SiO lines (full width at zero power (FWZP)) range from 3.4 to 55.1 km s$^{-1}$. A significant fraction ($\sim29\%$) of the detected SiO spectra have broad line widths (FWZP $>20~km~s^{-1}$), which are very likely associated with fast shocks driven by protostellar outflows. This result suggests that about one third of the SiO-detected SCCs are not really starless but protostellar. On the other hand, about 40$\%$ of the detected SiO spectra show narrow line widths (FWZP<10 $km~s^{-1}$) probably associated with low-velocity shocks which are not necessarily protostellar in origin. The estimated SiO column densities are mostly $0.31-4.32\times10^{12}~cm^{-2}$. Comparing the SiO column densities derived from SiO J=1-0 and 2-1 lines, we suggest that the SiO molecules in the SCCs may be in the non-LTE condition. The SiO abundances to H$_2$ are usually $0.20-10.92\times10^{-10}$.
The Weng'an biota and the Ediacaran radiation of multicellular eukaryotes

The rise of multicellularity represents a major evolutionary transition and it occurred independently in multiple eukaryote clades. Although simple multicellular organisms may have evolved in the Mesoproterozoic Era or even earlier, complex multicellular eukaryotes began to diversify only in the Ediacaran Period, just before the Cambrian explosion. Thus, the Ediacaran fossil record can provide key paleontological evidence about the early radiation of multicellular eukaryotes that ultimately culminated in the Cambrian explosion. The Ediacaran Weng'an biota in South China hosts exceptionally preserved eukaryote fossils, including various acanthomorphic acritarchs, pseudoparenchymatous thalli, tubular microfossils, and spheroidal fossils such as Megasphaera , Helicoforamina , Spiralicellula , and Caveasphaera . Many of these fossils have been interpreted as multicellular eukaryotes, although alternative interpretations have also been proposed. In this review, we critically examine these various interpretations, focusing particularly on Megasphaera , which has been variously interpreted as a sulfur-oxidizing bacterium, a unicellular protist, a mesomycetozoean-like holozoan, a volvocine green alga, a stem-group animal, or a crown-group animal. We conclude that Megasphaera is a multicellular eukaryote with evidence for cell-to-cell adhesion, a flexible membrane unconstrained by a rigid cell wall, spatial cellular differentiation, germ-soma separation, and programmed cell death. These features are inconsistent with the bacterium, unicellular protist, and mesomycetozoean-like holozoan interpretations. Thus, the surviving hypotheses, particularly the stem-group animal and algal interpretations, should be further tested with additional evidence. The Weng'an biota also hosts cellularly differentiated pseudoparenchymatous thalli with specialized reproductive structures indicative of an affinity with florideophyte red algae. The other Weng'an fossils reviewed here may also be multicellular eukaryotes, although direct cellular evidence is lacking in some and phylogenetic affinities are poorly constrained in others. The Weng'an biota offers many research opportunities to resolve the life histories and phylogenetic diversity of early multicellular eukaryotes and to illuminate the evolutionary prelude to the Cambrian explosion.
Differential Effects of Dietary Acidulated Soybean Oil Soapstock, Cottonseed Oil Soapstock and Tallow on Broiler Carcass Fat Characteristics

Abstract The degree of saturation of carcass fat (both visceral and muscular) of broilers was significantly affected by the type of dietary fat and its level. The most saturated carcass fat was obtained from feeding diets supplemented with tallow, or diets not containing any fat supplement, followed by dietary acidulated cottonseed oil soapstock (ACS), with soybean oil soapstock (ASS) leading to the least saturated body fat. The effect of ACS seems to be partly due to interference with the metabolic desaturation of stearic acid. Withdrawing the ASS from the diet at 5 weeks of age, or replacing it at this stage by either tallow or ACS, decreased significantly the degree of unsaturation of muscular and visceral fat at 8 weeks. The degree of saturation of visceral fat was reflected in pronounced changes in the latter’s melting point and stability towards oxidation. ACS resulted in body fat having a higher melting point than expected from the degree of its unsaturation. The stability of meat (TBA test) of broilers fed ASS was significantly lower than that obtained on diets containing tallow.
Chiari Malformation and Attention Deficit Hyperactivity Disorder

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition characterized by inattention, hyperactivity, and impulsivity. Chiari malformations (CM), first described approximately a hundred years ago, refer to a spectrum of hindbrain malformations characterized by cerebellar herniation through the foramen magnum. We present the case of a 28-year-old woman with ADHD and concurrent Chiari malformation type I (CM-I) that was diagnosed by CT scan. There is growing evidence supporting the role of the cerebellum and its associated structures in the pathophysiology of ADHD. Thus, a cerebellar malformation such as CM may impact neurological circuitry in a manner favoring the development of a neuropsychiatric disorder such as ADHD. Our case highlights the need for further studies pertaining to the role of the cerebellum in the pathophysiology of ADHD and the importance of considering the presence of CM when evaluating a patient with ADHD.