Miracle-dz/UniFAR-FTUs huggingface dataset:
Tibolone and transdermal E2/NETA for the treatment of female sexual dysfunction in naturally menopausal women: results of a randomized active-controlled trial.

INTRODUCTION There are some data to suggest that tibolone improves sexual function in postmenopausal women. However, evidence about the effects of tibolone on female sexual dysfunction is lacking. AIM To compare the efficacy on sexual function of tibolone 2.5 mg to continuous combined transdermal estradiol (E2)/norethisterone acetate (NETA) (50 microg/140 microg) in naturally postmenopausal women with sexual dysfunction. MAIN OUTCOME MEASURE Differences between treatment groups in the change from baseline for the composite subscore of the arousal, desire, and satisfaction domains of the self-reported Female Sexual Function Index (FSFI). METHODS A multicenter, double-blind, randomized, clinical trial was performed. Sexual function was assessed with the FSFI at baseline, week 12, and week 24. The outcomes of the Female Sexual Distress Scale (FSDS) and the frequency of satisfying sexual events (daily diaries) were secondary end points. RESULTS Four hundred three women, mean age 56, were included. Both therapies improved sexual function assessed by the FSFI. In the per protocol analysis, but not in the intent-to-treat analysis, the increase in FSFI scores was significantly larger in the tibolone group when compared with the E2/NETA patch group at week 24 (P = 0.036 and P = 0.025 for the composite subscore and total FSFI score, respectively). The satisfying sexual event rate increased from three to four times per 28 days at week 24 (P < 0.001 from baseline for both groups), with no difference between groups. The FSDS showed a significant decrease from baseline (P < 0.001), which was comparable for both treatment groups. CONCLUSIONS Both treatments resulted to improved overall sexual function, as determined by scores on the FSFI, an increase in the frequency of sexual events, and a reduction in sexuality-related personal distress. The statistically significant higher FSFI scores in the tibolone group, when compared to the E2/NETA group, may be because of tibolone's combined estrogenic and androgenic properties.
Lived Experiences of Iranian Parents of Children with Autism Spectrum Disorder: A Systematic Review

Background: Autism is a lifelong condition that seriously affects many aspects of children’s and families’ lives. The experience attained by living with a child with autism can be a valuable source of information to provide support and satisfactory services to children with autism and their families. We aimed to investigate the lived experiences of Iranian parents of children with autism. Methods: The search was conducted in PubMed, Web of Science, Embase, Google Scholar, CINAHL, PsychInfo, SID, and Magiran until Nov 2021. Two reviewers screened the articles, applied inclusion criteria, critically evaluated articles using the Critical Appraisal Skills Program (CASP), and extracted study details according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Thematic synthesis was used to analyze included studies. Results: From 2772 articles in the initial search, sixteen studies entered the final analysis. Four themes emerged, including treatment-related lived experience, individual lived experience, social lived experience, and occupational lived experience. Iranian parents of children with autism are confronted with negative experiences, including inaccurate diagnostic processes, lack of adequate support at the diagnosis time, low-quality treatment, psychological problems, and concern about the child’s future. Also, Parent’s experiences showed family problems, stigma, and problems with doing occupations. Conclusion: Practitioners, policy-makers, and regulatory organizations should urgently consider issues mentioned in the parents’ experiences to provide proper healthcare services for children with autism and their families.
Can Female Directors and Commissioners Reduce Stock Price Crash Risk: Evidence from LQ45 Indexed Company

This study empirically examines female directors and female commissioner’s affects stock price crash risk. This research was conducted on companies listed on the IDX's LQ-45 index in 2019-2021 by applying the fixed effect model (FEM) on GLS regression model. We prove that female board of directors and board of commissioners can reduce the stock price crash risk of the company by using several six control variables, those are return on asset (ROA), Leverage, Market to Book Value Ratio, RET, Sigma, and Size. The female directors and commissioners in this study are represented numerically with the results according to the assumption that the significance in the economic field, especially the risk of falling stock prices in companies, is a company that has a board of directors and a board of commissioners of women in its positions.
Magnetization of 0–26.5 Ma seafloor at the ultraslow spreading Southwest Indian Ridge, 61°–67°E

We investigate the magnetic signature of volcanic and nonvolcanic seafloor areas along the Southwest Indian Ridge between 61°E and 67°E and analyze their relationship with crustal thickness variations and past to present ridge segmentation. This part of the Southwest Indian Ridge is an end‐member for the global ridge system in terms of low melt supply, thin crust, and ultraslow spreading rates. It is characterized by large expanses of seafloor that show no evidence for a volcanic upper crustal layer. We find that variations of intrinsic magnetization and thickness of the basaltic extrusive layer, where it is present, dominate the present‐day along‐axis crustal magnetization. Off‐axis, the magnetization contrast is on average higher for volcanic seafloor than for smooth nonvolcanic topography, indicating that the contribution of the basaltic upper crustal layer to the production of magnetic anomalies remains important. However, magnetic anomalies that record past magnetic polarity events are found almost everywhere in the survey area, even over domains that lack a volcanic upper crustal layer, arguing thus for the contribution of other sources. We propose that both gabbros and serpentinized peridotites contribute to these anomalies. Although not systematic, and weak over most parts of the survey area, an induced component of magnetization is clearly present in some nonvolcanic seafloor domains. Serpentinized peridotites are the likely carriers of this induced magnetization component.
Clinical profile and immediate outcome of Multisystem Inflammatory Syndrome in Children (MIS-C) associated with Covid-19: a multicentric study

Mortality (9%) of our study is higher to 1.8–3% from western literature. None of our patient had coronary abnormality while 2 had mild cardiac dysfunction at discharge comparable to other studies. CONCLUSION: MIS-C following exposure to COVID 19 infection in children is a clinical syndrome which needs early suspicion and appropriate intervention to prevent mortality.
The Zero-Beta Interest Rate

We use equity returns to construct a time-varying measure of the interest rate that we call the zero-beta rate: the expected return of a stock portfolio orthogonal to the stochastic discount factor. The zero-beta rate is high and volatile. In contrast to safe rates, the zero-beta rate fits the aggregate consumption Euler equation remarkably well, both unconditionally and conditional on monetary shocks, and can explain the level and volatility of asset prices. We claim that the zero-beta rate is the correct intertemporal price. *We would like to thank Marianne Andries, Adrien Auclert, Jonathan Berk, John Cochrane, Darrell Duffie, Lars Hansen, Benjamin Holcblat, Arvind Krishnamurthy, Eben Lazarus, Mortiz Lenel, Martin Lettau, Hanno Lustig, Thomas Mertens, Monika Piazzesi, Mikkel Plagborg-Møller, Shri Santosh, Martin Schneider, Ken Singleton, David Sraer, Chris Tonetti, and Motohiro Yogo for helpful comments, as well as seminar and conference participants. We would particularly like to thank Rohan Kekre for an excellent discussion of our paper. We would also like to thank Paul Delatte for his research assistance. An earlier version of this paper circulated as “The Zero-Beta Rate. ” Replication code (requires a WRDS account): https://github.com/bhebert/TheZeroBetaRate The interest rate is one of the most important prices in a market economy. It captures the intertemporal price of goods and plays a central role in business cycles and monetary policy. In this paper we use equity returns to construct a measure of the interest rate that we call the zero-beta rate: the expected return of a stock portfolio orthogonal to the stochastic discount factor (SDF). Compared to safe rates, the zero-beta rate is high and volatile, and fits a stable aggregate consumption Euler equation remarkably well, both unconditionally and conditionally on monetary shocks. Furthermore, it is high, volatile, and persistent enough to explain the level and volatility of asset prices. We claim that the zero-beta rate is the correct intertemporal price. Our motivation starts with the aggregate consumption Euler equation, 1 = Et [ δ ( ct+1 ct )−σ Rt+1 Pt+1/Pt ]
MANAGEMENT OF CALCULUS ANURIA – OUR EXPERIENCE

Background: To determine the outcome of treatment for patients with calculus anuria. Materials and Methods: A retrospective study was conducted at Department of Urology Govt. Medical College/GGH, Mahabubabad from February 2021 to February 2023. All patients with a diagnosis of calculus anuria of all ages and either sex were included in the study. Detailed history, physical examination and examination of genitourinary tract were performed. Investigations included complete blood examination, blood urea, and serum creatinine, ultrasonography of KUB area, and X-Ray KUB and noncontrast CT abdomen KUB for radiolucent calculi. Result: Among the 37 patients the cause of anuria was bilateral obstruction by the calculi in 33 cases, unilateral obstruction with absent/peviureteric junction obstruction contralateral kidney in 4 cases. All patients underwent dialysis (either hemo or peritoneal dialysis). In most of the cases, ureteric double J stenting/percutaneous nephrostomy was done to relieve the obstruction. Two deaths were observed, despite emergency urinary diversion and appropriate treatment. Definitive management ureteroscopic lithotripsy/percutaneous nephrolithotomy / ureterolithotomy / extracorporeal shock wave lithotripsy was done after renal parameters were normalized. Conclusion: Calculus anuria is a urological emergency. Prompt and early intervention can save the life of patient and prevent to develop chronic renal failure.
"Wasteful" Commuting: A Resolution

A debate over the empirical underpinnings of urban economic models is emerging under the unlikely rubric of wasteful commuting. Hamilton (1982) shows that a commonly used monocentric model, in which employment and population densities decline exponentially from a center, greatly underpredicts actual commuting distances in typical U.S. and Japanese metropolitan areas. He concludes that the monocentric model is fundamentally flawed. This conclusion is challenged by White (1988b), who examines the cost-minimizing assignment of households to residential locations, taking density patterns as they are and measuring cost by travel time. White finds that for a sample of U.S. metropolitan areas, only 11 percent of actual commuting cost is in excess of the cost-minimizing amount, rather than the 87 percent found by Hamilton. Hamilton (1989) and Cropper and Gordon (1991), using variations of White's technique, obtain results intermediate between these extremes.
A Regression Modelling Approach for Stem Volume Estimation of Two Exotic Plantations within Dogo-Kétou Forest Reserve, Benin Republic

: Stem volume models play an important role in forest management, evaluating the economic value of a forest stand and assisting forest managers and other interested parties in determining the optimal strategies for the utilization and conservation of forest resources. Little attention is given to the use of multivariate regression models for plantation species in the study area. This study involved the development of a multivariate regression equation with continuous and categorical independent variables for simultaneous prediction of merchantable volume for Gmelina arborea and Tectona grandis in Dogo-Ketou Forest Reserve. Simple random sampling technique was adopted for plot location from the selected two plantations. Thirty-one temporary plots of dimension 25m by 25m were selected for complete enumeration in all the two plantations of the same age. Tree growth variables measured included diameter at breast height (Dbh) and merchantable height. All data obtained were analyzed using descriptive statistics and multivariate regression analysis. The predictors for the equation were Dbh, merchantable height and tree species type. The results of the analysis revealed that Gmelina arborea exhibited higher average Dbh and height, wider Dbh and height range, more pronounced positive skewness in Dbh distribution, and more negative skewness in height distribution compared to Tectona grandis . Kurtosis values indicated relatively flatter Dbh and height distributions for both species, with Gmelina arborea showing a more peaked height distribution. Gmelina arborea also showed higher mean volume than Tectona grandis . The multivariate regression model developed is: Volume (m 3 ) = -0.467 + 0.024*(Height) + 2.683*(Dbh) + 0.016 (Tree species) with R 2 of 91.3%. The diameter at breast height (Dbh), height, and tree species were found to be statistically significant predictors for stem volume estimation. The developed model for both plantation species will provide useful basis for yield prediction in the study area.
Modelling Worker Residence Distribution in the Los Angeles Region

This paper examines the spatial pattern of worker residences with three different density functions: monocentric, polycentric and dispersive. Analysis of the 1980 journey-to-work census data for the Los Angeles region reveals that the polycentric density function statistically explains the actual distribution better than the monocentric density function, but the dispersive density function fits best. These findings confirm a polycentric spatial pattern, and also imply that overall accessibility to employment opportunities is the primary determinant of residential location choices.
Effects of afforestation on soil fungi in rocky mountain areas of North China

Afforestation has a substantial influence on soil fungal communities by introducing ecological variations within forest ecosystems via the inclusion of distinct tree species (coniferous and broadleaf) and afforestation patterns (pure forests and mixed forests). However, the specific effects of these variations on soil fungal communities require further investigation. Soil samples from birch (B: Betula platyphylla Suk.), larch (L: Larix gmelinii (Rupr.) Kuzen. ), and mixed birch and larch (B–L) forests were used in this study, and a shrub–grassland field (S–G) was used as a reference. The abundance, diversity, and community composition of fungi in the soil of the monoculture forest (B and L), mixed forest (B–L), and S–G were studied by high‐throughput sequencing. The results showed that Basidiomycota was the dominant fungus in B and B–L, and the dominant genera were Inocybe and Amanita, respectively. Ascomycota was the dominant fungus in L and S–G, and the dominant genus was Mortierella. Afforestation reduced the richness and diversity of soil fungi. Larch forests were richer in soil fungi than B and B–L forests. Soil organic carbon was the main soil factor affecting the soil fungal community structure. Soil fungal community network changed less after planting L than after planting B and B–L, and the soil fungal community structure was more complex and stable in L than in B and B–L. For soil fungal community composition and function, mixed forests did not show outstanding advantages. Planting monoculture forests may be a more effective afforestation strategy in the rocky mountain areas of North China.
STUDY OF ORGANOPHOSPHORUS POISONING IN CONTEXT TO CHANGES IN ELECTROCARDIOGRAPHY, ECHOCARDIOGRAPHY, AND CARDIAC MARKERS

Background: Organophosphorus compounds are varied form of chemicals, produced by esterification of phosphoric acid and alcohol. Although such compounds are commonly encountered in everyday practices, these are toxic to human. The aim of the current investigation was to identify alterations in electrocardiography, echocardiography, and cardiac biomarker concentrations in cases of organophosphorus poisoning. Materials and Methods: A clinical prospective study was conducted on 50 individuals with organophosphorus poisoning. Clinical features, elctro-and echo-cardiographic changes were monitored. Cardiac enzymes were analyzed qualitatively using laboratory examinations. The statistical validation was done using Microsoft Excel and GraphPad Prism. Results: The results revealed that maximum patients examined were between 21-30 years (30%) with female:male ratio of 3.14:1. The mean age of patients was 27.54 ± 9.04 years. Majority of patients were of low-income groups. Most of the patients were admitted within 3.14 ± 1.6 hours. Vomiting (92%) and abdominal pain (66%) was common complaints of patients. Electrocardiographic changes included arrhythmia in 6% cases with 4% ventricular tachycardia and 2% ventricular fibrillations. 42% patients had bradycardia and 20% had tachycardia. No cardiac pathology was diagnosed in the echocardiograph. Specific cardiac enzymes creatine phosphokinase-MB and troponin-I were normal. Lactate dehydrogenase was elevated in three patients; however normal liver function and urine test ruled out probability of myocardiac and hepatic injury. Conclusion: The present findings concluded that patients with organophosphorus poisoning are detected with electrocardiographic change; however, most of the cardiac damages can be healed with time except ventricular fibrillation and associated pulmonary edema. Mortality rate of 6% could have been prevented with advanced diagnostic and prompt therapeutic interventions.
Identification, Quantification and Distribution of Polychlorinated Biphenyls (PCBs) in Sediments of the Rappahannock and York River Watersheds

/<~~. "\ Doctor of Philosophy /') . Environmental Science and Public Policy Committe~: /; /J / . i . ~:/. ":' f// " f<;:~:. :~'-,,· -----'-"-"~'-~--"~ . ~~ /t >"l<. ,p~·'4-----~ l Dr. Douglas Mose, Dissertation Director (':,~'~'.'. ? Y~4-~' ' LC~ll J . i (/ Dr. George Mushrush, Committee Member ;;? ~"-) 1~·~/i~:~i:. ~~~"~~~~~·t '~ ',', / <>" ;/«"'"~'r' ~,t:j~r,:::, ",' ". 0/ "'~'iJ'¥~p'! ",. , t ,0;"' Dr. Carol Litchfield, Committee Member
Simulation of the Microphysical Processes and Effect of Latent Heat on a Heavy Rainfall Event in Beijing

Abstract An extraordinary rainstorm that occurred in Beijing on 21 July 2012 was simulated using the Weather Research and Forecasting model. The results showed that: (1) The two precipitation phases were based on a combination of cold cloud processes and warm cloud processes. The accumulated conversion amount and conversion rate of microphysical processes in the warm-area phase were all much larger than those in the cold front phase. (2) 72.6% of rainwater was from the warm-area phase. Rainwater mainly came from the melting of graupel and the melting of snow, while the accretion of cloud water by rain ranked second. (3) The net heating rate with height appeared as an overall warming with two strong heating centers in the lower and middle layers of the troposphere and a minimum heating center around the melting layer. The net heating effect in the warm-area phase was stronger than that in the cold front phase. (4) Warm cloud processes contributed most to latent heat release, and the thermal effect of cold cloud processes on the storm in the cold front phase was enhanced compared to that in the warm-area phase. (5) The melting of graupel and snow contributed most to latent heat absorption, and the effect of the evaporation of rainwater was significantly reduced in the cold front phase.
H∞ Consensus for Multiagent-Based Supply Chain Systems Under Switching Topology and Uncertain Demands

Supply chain systems are network systems with several subchains each of which consists of facilities and distribution entities (suppliers, manufacturers, distributors, and retailers), and thus such systems can be viewed as multiagent systems. Consensus or coordination of multiple subchains is crucial for a stable market supply, especially in the case of some subchains suffering from production interruption, or losing connection with others, which become isolated subchains in some time period due to irresistible reasons. Once some unspecified isolated subchains appear, the topology structure of the system will be changed, and thus the multiagent-based supply chain system can be modeled as a switched system. This paper aims to investigate the problem of ${H_\infty }$ consensus for multiagent-based supply chain systems under switching topology and uncertain demands. To achieve the consensus of the system, switching controller is designed in which both production rate and distributed consensus protocol are considered. Sufficient conditions are given such that the whole system reaches consensus and desirable attenuation of bullwhip effect with an average dwell time approach, which allows some subchains to be isolated in some time periods. Finally, a simulation example is presented to illustrate the effectiveness of the proposed method.
Petrological and volcanological constraints on volcanic sulfur emissions to the atmosphere

A review of current knowledge about the physics of volcanic eruptions and the experimental constraints on sulfur behavior in magmas is presented with the aim of evaluating the range of sulfur yields from major explosive eruptions based on petrological and volcanological data. The so-called petrologic method, used to evaluate syn-eruptive melt degassing, is expanded by also considering the role of a pre-eruptive gas phase. It is shown that more than 90% of the atmospheric sulfur loading may come from release of the pre-eruptive gas phase during eruptions of intermediate to silicic magmas at subduction-related volcanoes. In contrast, the role of a pre-eruptive gas phase may be much less important in more mafic magmas erupted in other tectonic settings. Bulk sulfur contents are weakly (spreading-ridges and hot spots) to non-correlated (subduction-zones) with bulk-rock composition. With the exception of some persistently active volcanoes, bulk sulfur contents generally do not exceed 0.5 wt %. The sulfur yields are positively correlated with mass of erupted magma, but the dispersion in sulfur emission for a given erupted mass increases progressively as the erupted mass decreases. The sulfur yields of single eruptive events retrieved from this improved petrologic method are shown to closely agree with independent estimates obtained from analysis of ice cores, optical-depth measurements, and remote-sensing spectroscopic techniques (TOMS and COSPEC).