Miracle-dz/UniFAR-FTUs huggingface dataset:
Including children and adolescents with autism spectrum disorder in functional behavioural assessment-informed interventions for sleep disturbance

Objectives Sleep disturbances are a significant problem for individuals with autism spectrum disorder (ASD) across the lifespan; however, there is a paucity of research examining effective sleep interventions for adolescents with ASD. Although research has demonstrated individuals with ASD can be meaningfully engaged in their own intervention process, such engagement has not appeared in previous studies targeting sleep in adolescents with ASD. Methods This study investigated the feasibility of including pre-adolescents and adolescents (ages 9 to 14 years) with ASD as active intervention agents within comprehensive, individualized treatments for sleep problems. Participants had a range of intellectual functioning but all produced spoken language. Outcomes were evaluated using single-case designs. Results Data suggest intervention was effective in eliminating sleep disturbance for all participants. Improvements were maintained during 18to 24-month follow-up. All three participants and their parents indicated a high degree of treatment satisfaction. Conclusions Findings illustrate the feasibility and potential benefit of including adolescents with ASD in the process of developing and implementing individualized behavioral interventions for sleep problems.
Promotion of Alumina Supported Cobalt Catalysts by Iron

Several alumina supported cobalt (Co), iron (Fe) mono metallic, and Co–Fe bimetallic catalysts were synthesized, characterized, and studied for the carbon dioxide (CO2) hydrogenation reaction. The catalysts were synthesized by coimpregnation and double-impregnation methods, and characterized by X-ray diffraction (XRD), ultraviolet–visible-near infrared (UV–vis-NIR), and diffuse reflectance infrared fourier transform (DRIFT) spectroscopy. The surface areas of the catalysts were also determined. Appropriate amounts of Fe promote the catalytic reactivity of alumina supported cobalt catalysts for the CO2 hydrogenation reaction. Furthermore, it was beneficial that this catalyst was synthesized by the double-impregnation method, where Fe was initially deposited, and then, Co was deposited on the alumina support. The hydrogenation of CO2 revealed the presence of formate species on the catalyst during reaction. It appears that iron promotes the supported cobalt catalyst by (i) protecting cobalt from strongly inte.
Barriers and facilitators of completing the steps in the PMTCT cascade at Midwife Obstetric Units in Gauteng - Healthcare Provider and Patient's views

Background: The implementation of Prevention of Mother to Child Transmission (PMTCT) programmes at midwifes obstetric units (MOU) involves the confirmation of HIV diagnosis during labour, early infant HIV diagnosis (EID), initiation/continuation of antiretroviral therapy (ART) for mother and baby as appropriate and counselling for postpartum care. Objectives: The aim of this study was to explore the barriers and facilitators to completing the steps in the PMTCT cascade at MOUs as defined by healthcare providers and recently postpartum women. Methods: We conducted 10 in-depth interviews with healthcare providers, and 24 HIV positive and HIV negative women at the four MOUs and Primary Healthcare Centres (PHC’s) in Gauteng South Africa (SA). Results: The implementation of PMTCT at MOU is impeded by maternal denial of HIV status (both new diagnoses and ANC diagnoses). Challenges with acceptance and disclosure of HIV status were thought to compromise patient commitment to EID tests and postpartum adherence to infant ART. Newly diagnosed (during labour) patients have limited time to process new HIV diagnosis and clinics have limited nurse/counsellor capacity for further one on one counselling. Additional challenges include communication challenges with foreign women and turnaround time for birth HIV tests. Results are often not available at postnatal visit and unclear processes for referral to Primary Healthcare Centre (PHC) for postpartum care increase risk of postpartum loss to follow up. Conclusion: We need to strengthen MOU capacity to prepare women for postpartum PMTCT requirements and facilitate access to EID results. Patient referral processes, including communication of infant HIV test results to the referral PHC, needs improvement.
Practicability and effectiveness of the unassisted HIV self-testing compared to the directly assisted HIV self-testing in  the Democratic Republic of the Congo:  A Randomized Implementation Trial

Background. HIV self-testing (HIVST) may be use free or assisted by health care workers. The aim of this trial was to assess the practicability and effectiveness of unassisted HIVST (UH) versus directly assisted HIVST (DAH) in field settings in the Democratic Republic of the Congo (DRC). Methods. A non-inferiority evaluation using a blood-based HIV self-test was conducted in Kisangani, DRC. Participants were randomized in a 1:1 ratio to UH or DAH. Practicability was defined as the successful performance and the correct interpretation of the result. The linkage to care and the willingness to buy self-test constituted the outcome for HIVST effectiveness. Results. The rate of successful performance of the test was same (93.2%) in UH and DAH. The rate of correct interpretation of the results was 86.9% in UH versus 93.2% in DAH yielding the difference of -6.3% (95% CI: -10.8 to 2.5). UH significantly decreased the rate of correct interpretation of results as compared to DAH (aRR: 0.60 [95% CI: 0.36 to 0.98]; P=0.019). None significant difference was found between two arms in evaluating the linkage to care. Willingness to buy HIV self-test was higher in UH as compared to DAH (92.3% versus 74.1%; aRR: 4.20 [95% CI: 2.42 to 7.32]; P<0.001). Conclusion. This study demonstrates that both UH and DAH show high level of practicability and effectiveness for HIVST. However, additional support tools will be need to improve the practicability of the test in UH. Taken together, UH as well as DAH should improve access to HIV testing in DRC. Trial registration: PACTR201904546865585. Registered 03 April 2019 - Retrospectively registered, https://pactr.samrc. ac.za/TrialDisplay.aspx? TrialID=6032
Identification of Genes in Patients for Predicting Ulcerative Colitis-Associated Colorectal Cancer

BackgroundUlcerative colitis (UC) has been considered as a risk factor for colorectal cancer (CRC). However, effective biomarkers for predicting UC-associated CRC are lacking. Therefore, it is necessary to screen biomarkers associated with UC-related CRC, which could be used to evaluate UC-associated CRC early, and provide possible mechanisms involved in UC-associated CRC. Efficient bioinformatics analysis could help us to explore potential biomarkers.MethodsTwo public datasets, including 44 UC without CRC samples and 17 UC-associated CRC samples were chosen from Gene Expression Omnibus (GEO) database. Sva package was used to remove batch effects, and then we screened out differentially expressed genes (DEGs) with limma package. STRING and Cytoscape were used to achieve protein-protein interaction (PPI) network analysis. The survival curves between high and low gene expression were performed by log rank test based on the cancer genome atlas (TCGA) program. The expression of three identified hub genes was validated based on Oncomine. To validate the expression of three hub genes, we compared the expression of three hub genes between normal and colorectal cancer based on Oncomine.Results405 DEGs were identified, including 256 down-regulated genes and 149 up-regulated genes in UC-associated CRC tissues. 16 hub genes were identified. And among them, RPL6, RPL7, and RPL35 were related to poor prognosis of patients in survival analysis. Higher expression of RPL6, RPL7, and RPL35 was validated in CRC tissues based on Oncomine.ConclusionsOur study showed that overexpressed RPL6, RPL7, and RPL 35 may be potential tumor oncogenes and could act as a prognostic factor in clinical diagnosis and treatment.
Growing of Polyporus umbellatus

Polyporus umbellatus is a valuable edible and medicinal fungus. Growth of two P. umbellatus strains 2510 and 2511 was studied on various plant substrates and their compositions. Fruit bodies of P. umbellatus were produced after successful mycelial colonization of the substrates with added freshly fallen oak leaves, wheat and sunflower seed shells. Using this growing method, the small fruit bodies (2.5 × 3.5 cm, 60–70 g) of P. umbellatus, strain 2511, developed on day 78, including 25 days of cultivation on MEA, 35 days of cultivation on substrate containing 50 g of wheat grain and sunflower husk with ratio 80:20, and 18 days cultivation on substrate containing 600 g freshly fallen oak leaves.
Motivation and self-efficacy influence in the academic performance of Secondary students-athletes

The present study investigated the relationship between Academic Performance, Goal-orientations, Motivation, self-efficacy and Academic satisfaction. Seventy-four healthy secondary school students-athletes participated in the present research. The results showed correlations between the different variables analysed. Thus, we found a positive correlation between self-efficacy and qualifications, and task-goals with achievements-motive. However, the avoidance of negative judgments correlates negatively with task-goals and positively with inhibitor anxiety. Comparative analysis showed that were no differences according to gender, although significant differences were depending on the level of academic, mainly in ego-goals. Finally, another comparative analysis using the scores an independent variable, showed that students with higher grades presented more orientation to the goals-task and greater self-efficacy. The present study demonstrates a positive correlation between self-efficacy and ratings or score, task-goals, and achievementsmotive. Thus, we can suggest an individualized study of each child where self-efficacy could be seen as a means of predicting new results.
Determinants of High Fertility Rate among Married Women in Ethiopia

Background: Fertility is one the major components of changing the population size and structure over time. Hence, this study aims to identify the socioeconomic and demographic factors associated with the high fertility rate among married women in Ethiopia Method: Ethiopian demography and health survey of 2016 data were accessed and used for the analysis. A total of 9602 married women were included in the study. Poisson regression models were employed by considering the number of children ever born (count) as a response variable. Results: A total of 9602 married women were included and 907 (9.4%) of the mothers have not born a child in their life time and only 307 (3.2%) of them have born more than 9 children. Rich women (IRR =0.794; 95%CI: 0.685, 0.920, secondary and above education of women (IRR =0.602; 95%CI: 0.570, 0.635), secondary and above education level of husbands’ (IRR =0.917; 95%CI: 0.880, 0.955) and late marriage (IRR =0.853; 95%CI: 0.832, 0.873) were found significantly associated with low level of fertility rate. Small family size (IRR =2.23.; 95%CI: 2.168, 2.294) and being child death experience (IRR =1.636; 95%CI: 1.601, 1.672) were also showed statistically significant association with high level of fertility rate. Conclusion: The government should focus on providing better access to education, increasing the coverage of family planning service and improving sources of income. Furthermore, the society should be made aware on consequences of high fertility on the child and maternal health, household economy, human capital investment and environmental degradation.
Supporting breastfeeding at work in a public sector setting: A qualitative exploratory study among managers and employed mothers

Background: Return to employment is a major barrier to breastfeeding continuation, globally and in the Southern African context. The Lancet breastfeeding series revealed an explicit need for research exploring breastfeeding as a workplace issue in low- and middle-income countries. A dearth of research on workplace breastfeeding in South Africa, and limited awareness about legislation to protect breastfeeding employees, calls for attention to this topic. Methods: This qualitative study explored experiences of workplace breastfeeding amongst employed mothers and senior managers in two provincial government departments in South Africa. Twelve in-depth interviews were conducted with senior managers ( n = 4) and employed mothers ( n = 8). Results: Thematic analysis of the data revealed findings important to understanding mothers’ decisions about breastfeeding at work, across three critical maternity periods: 1) During pregnancy: poor knowledge about comprehensive maternity benefits and an absence of a conversation on infant feeding plans with managers meant mothers were disempowered to make informed choices about breastfeeding at work; 2) During maternity leave: stress from anticipated work-family conflict and logistical considerations influenced mothers’ decisions to wean infants; and 3) Upon return to work: mothers experienced a lack of workplace infrastructural support for breastfeeding. Conclusion: Our study contributions emphasise that breastfeeding support from managers should begin prior to the mother taking maternity leave. Immediate supervisors were found to be an important but overlooked agent to enforce legislation and provide breastfeeding support. Implications for management for advancing support for breastfeeding at work in the public sector are presented.
Copeptin assessment to predict vasoplegia after cardiopulmonary by-pass. An observational cohort study.

Background Post-cardiotomy vasoplegic syndrome is a vasodilatory shock characterized by a decrease of vascular tone with a normal or increased cardiac output. A relative deficit in vasopressin secretion in the postoperative was hypothesized. Copeptin is secreted in equimolar ratio with vasopressin but it is more stable and easier to measure. The aim of the present study was to investigate whether perioperative copeptin was associated with post-cardiotomy vasoplegic syndrome. Methods All patients scheduled for cardiac surgery were evaluated. Exclusion criteria were age < 18 years old, corticosteroids therapy, heart transplantation, extra-circulatory life support, sepsis, preoperative use of vasoactive drugs, off-pump surgery, chronic hepatic and renal failure, paraneoplastic syndrome, lack of informed consent. Post-cardiotomy vasoplegic syndrome was defined as a mean arterial pressure < 60 mmHg, a reduction of systemic vascular resistances < 1200 dyn*s/cm 5 *m 2 and/or the need of nor-epinephrine ³ 0.1 µg/kg/min. All patients underwent a preoperative evaluation of the corticotropin stimulation test; then, before surgery (T0), on day one after surgery (T1) and after 7 days (T2) copeptin and NT-proBNP concentration were measured. Results Among 55 enrolled patients, 9 (16.3%) developed post-cardiac surgery vasoplegia. Patients with vasoplegia had higher preoperative level of copeptin (19.2 pmol/L, IQR 17.89 – 21.29 vs 11.39 pmol/L, IQR 6.33 - 14.78; p < 0.001) and NT-proBNP (1435 pg/ml, IQR 721.75 – 1836.25 vs 365.5 pg/ml, IQR 141 - 977); p = 0.006) compared to the control group. At the multivariable analysis, preoperative copeptin resulted a significant predictor of vasoplegia (OR 1.56, 95% CI 1.002-1.33) and the ROC analysis showed an accurate copeptin cut off able to identify vasoplegic patients (> 16.9 pmol/L, AUC = 0.86, 95% CI 0.73-0.94). Otherwise, a lack of response to the low dose corticotropin test was not a predictor of PCVS; no patient presented a pathological response to the standard dose test. ConclusionsIncreased preoperative copeptin and NT-proBNP levels might be associated with an increased risk to develop post-cardiotomy vasoplegic syndrome. Our results suggest that patients with a decompensated neuroendocrine control of cardiovascular function are more prone to develop postoperative vasoplegia.
Specific Antibiofilm of Carbon Quantum Dots by Destroying P. gingivalis Biofilm Related Proteins Self-assembly

Biofilms protected bacteria from antibiotics and produced drug-resistant strains, especially the main pathogen of periodontitis- Porphyromonas gingivalis ( P. gingivalis ). In this investigation, the carbon quantum dots (TCDs and MCDs) were prepared by hydrothermal method with clinic antibacterial drug-Tinidazole and Metronidazole and exhibited unique antibiofilm properties. The transmission electron microscope (TEM) images showed that the TCDs and MCDs had uniform sizes and the results of UV-vis and energy dispersive spectrometer (EDS) confirmed their important carbon polymerization structures. The prepared TCDs and MCDs were characterized by infrared spectroscopy and still kept the activity of nitro group, which still had an obvious effect on P. gingivalis . Interestingly, the results showed that they both have significant antibacterial effect on P. gingivalis , while the effect of TCDs was better than MCDs. However the TCDs has almost ineffect on other bacteria including Escherichia coli ( E. coli ), Staphylococcus aureus ( S. aureus ) and Prevotella nigrescens ( P. nigrescens ), the MCDs still have obviously antibacterial ability to P. ningrescens . Importantly, the TCDs can penetrate the biofilms to further effectively inhibited the growth of P. gingivalis under the biofilms. Furtherly, we revealed the hydrophilic TCDs destroy P. gingivalis ’ adhesion and impair toxicity by inhibiting the major virulence factors and related genes involved in biofilm formation of P. gingivalis, thus affect the self-assembly of biofilm related proteins. The findings may not only develop a new promising method for improve the periodontitis treatment efficiency by penetrating P. gingivalis biofilm with preparation of nano-level antibacterial drugs.
Experimental and DFT Studies on the Behavior of Caffeine as Effective Corrosion Inhibitor of Copper in 1M HNO3

Caffeine was tested as copper corrosion inhibitor in 1M HNO 3 using mass loss technique at 308-328K and theoretical studies based on quantum chemistry. The inhibition efficiency is concentration and temperature dependent: Caffeine showed an inhibition efficiency of 78% at 5mM for T =328K. The thermodynamic adsorption parameters ( were determined and analyzed. They revealed a spontaneous adsorption process and a strong interaction between Caffeine and the metal surface. Adsorption isotherms including Langmuir, Temkin and El-Awady were tested. It was found that Caffeine adsorbs on copper according to the modified Langmuir adsorption isotherm. The Dubinin Raduskevitch model was used to distinguish between chemisorption and physisorption. Activation parameters ( were also determined and discussed. Furthermore, the quantum chemical properties/descriptors most relevant to the potential action of the molecule as corrosion inhibitor such as highest occupied molecular energy (E HOMO ), lowest unoccupied molecular orbital energy (E LUMO ), energy gap(∆E), dipole moment ( and charges on heteroatoms were calculated using DFT at B3LYP level with 6-31+G (d) and LanL2DZ basis sets. Fukui indices were also determined and discussed. The theoretical results are consistent with the experimental data reported. DOI: http://dx.doi. org/10.17807/orbital.v8i2. 804
Plasma Proteomics Analysis for Screening Anlotinib Responders in Non-small Cell Lung Cancer

Background Anlotinib has been demonstrated to be effective in advanced non-small cell lung cancer (NSCLC) patients. The underlying value of proteomics for anlotinib study remains unclear. Methods In this study, plasma samples from 28 anlotinib-treated NSCLC patients (including 14 responders and 14 non-responders) were performed proteomics analysis. LC-MS/MS analysis was performed on those samples with different time points including baseline, best response and progression disease. Bioinformatics analysis was performed to understand the underlying value of those differential proteins. Results Proteomics analysis suggested the differential proteins from responders after anlotinib administration potential play a role in the molecular mechanism characterization and biomarker screening. The differential proteins between responders and non-responders at baseline mainly contribute to biomarker screening. Integrative analysis indicated 43 proteins could be used as underlying biomarkers for clinical practice. Lastly, we selected ARHGDIB and demonstrated that it has potential predictive value for anlotinib. Conclusions This study not only offered the first insight that the proteomic technology potentially be used for anlotinib molecular mechanism characterization, but also provided a basis for anlotinb biomarker screening via proteomics in the future.
THEORETICAL STUDIES OF AIR IONIZATION AND NO VIBRATIONAL EXCITATION IN LOW DENSITY HYPERSONIC FLOW AROUND RE-ENTRY BODIES.

This paper deals with calculation of thermochemical nonequilibrium low density hypersonic air flows. A multi-temperature thermochemical model was developed for simulation of air ionization in low density regime. Nonequilibrium dissociation and exchange reaction model was verified and corrected using flight test data on electron density. Good agreement between RAM-C flight experiments and calculations was obtained. Modified wall boundary conditions for vibrational temperatures and charged species concentrations were suggested. Finally, the flowfield and UV and IR radiation around SKIPPER vehicle were calculated using the presented model.
Processing symbolic magnitude information conveyed by number words and by scalar adjectives

Humans not only process and compare magnitude information such as size, duration, and number perceptually, but they also communicate about these properties using language. In this respect, a relevant class of lexical items are so-called scalar adjectives like “big,” “long,” “loud,” and so on which refer to magnitude information. It has been proposed that humans use an amodal and abstract representation format shared by different dimensions, called the generalised magnitude system (GMS). In this paper, we test the hypothesis that scalar adjectives are symbolic references to GMS representations, and, therefore, GMS gets involved in processing their meaning. Previously, a parallel hypothesis on the relation between number symbols and GMS representations has been tested with the size congruity paradigm. The results of these experiments showed interference between the processing of number symbols and the processing of physical (font-) size. In the first three experiments of the present study (total N = 150), we used the size congruity paradigm and the same/different task to look at the potential interaction between physical size magnitude and numerical magnitude expressed by number words. In the subsequent three experiments (total N = 149), we looked at a parallel potential interaction between physical size magnitude and scalar adjective meaning. In the size congruity paradigm, we observed interference between the processing of the numerical value of number words and the meaning of scalar adjectives, on the one hand, and physical (font-) size, on the other hand, when participants had to judge the number words or the adjectives (while ignoring physical size). No interference was obtained for the reverse situation, i.e., when participants judged the physical font size (while ignoring numerical value or meaning). The results of the same/different task for both number words and scalar adjectives strongly suggested that the interference that was observed in the size congruity paradigm was likely due to a response conflict at the decision stage of processing rather than due to the recruitment of GMS representations. Taken together, it can be concluded that the size congruity paradigm does not provide evidence in support the hypothesis that GMS representations are used in the processing of number words or scalar adjectives. Nonetheless, the hypothesis we put forward about scalar adjectives is still is a promising potential line of research. We make a number of suggestions for how this hypothesis can be explored in future studies.