Miracle-dz/UniFAR-FTUs huggingface dataset:
Comportamiento poscosecha de frutos de ciruela ( Prunus salicina Lindl.) en cuatro estados de madurez tratados con etileno

La aplicacion de etileno en frutos es comunmente utilizada para uniformizar el color y acelerar la maduracion, de esta manera se puede mejorar la apariencia y las caracteristicas organolepticas. Por lo anterior, se trataron frutos de ciruela variedad Horvin recolectados en cuatro estados de madurez (2, 3, 4 y 5), con etileno comercialmente conocido como Ethrel en dosis de 100 μL L -1 . Se utilizo un diseno completamente al azar con cuatro tratamientos (correspondientes a los estados de madurez) cada uno con 4 repeticiones, para un total de 16 unidades experimentales compuestas cada una por 400 g de frutos aproximadamente. Cada tres dias se midio el color, perdida de peso, tasa respiratoria, firmeza, pH, acidez total titulable (ATT) y solidos solubles totales (SST). Se realizaron mediciones hasta que los frutos perdieron calidad organoleptica. En las variables perdida de peso, firmeza, SST, ATT y pH no hubo diferencia significativa en la mayoria de los puntos de muestreo. En cuanto al color hubo diferencias estadisticas. La tasa de respiracion y la relacion de madurez al final de las mediciones presentaron diferencias significativas, obteniendo los mayores valores en el estado de madurez 5 y los menores valores en los estados 3 y 2 respectivamente. Por lo tanto, el uso de etileno en frutos de ciruela es benefico ya que favorece el cambio de color y aumenta la relacion de madurez, por lo que garantiza en almacenamiento uniformidad entre estados de madurez.
The conductor of an abelian variety

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Metabarcoding and Metabolome Analyses Reveal Mechanisms of Leymus chinensis Growth Promotion by Fairy Ring of Leucocalocybe mongolica

Fairy rings are a unique ecological phenomenon caused by the growth of the fungal mycelium in the soil. Fairy rings formed by Leucocalocybe mongolica (LM) are generally distributed in the Mongolian Plateau, where they promote plant growth without fertilization and alleviate fertilizer use. We previously investigated the soil factors regulating growth promotion in a fairy ring ecosystem; however, the aspects of the plant (Leymus chinensis, LC) that promote growth have not been explored. Therefore, the present study investigated the endophyte diversity and metabolome of LC in an LM fairy ring ecosystem. We analyzed the leaf and root samples of LC from the DARK (FR) and OUT (CK) zones. The fairy rings significantly improved the fungal diversity of roots and leaves and the bacterial diversity of leaves in the FR zone. Ralstonia was the dominant bacteria detected in the LC leaves. In addition, Marasmius, another fairy ring fungal genus, was also detected with a high abundance in the roots of the FR zone. Furthermore, widely targeted metabolome analysis combined with KEGG annotation identified 1011 novel metabolites from the leaves and roots of LC and seven pathways significantly regulated by the fairy ring in the FR zone. The fairy ring ecosystem significantly downregulated the flavonoid metabolism in the leaves and roots of LC. The correlation analysis found Ralstonia is a potential regulatory factor of flavonoid biosynthesis in LC. In addition, salicylic acid and jasmonic acid were found upregulated in the leaves, probably related to Marasmius enrichment. Thus, the study details plant factors associated with enhanced growth in an LM fairy ring ecosystem. These findings lay a theoretical foundation for developing the fairy ring ecosystem in an agricultural system.
TEMPO-oxidized cellulose beads for cationic dye adsorption

Toxic organic dyes present in wastewater should be removed before discharge. In this study, TEMPO-oxidized, regenerated cellulose beads were prepared using a simple falling ball technique for cationic methylene blue (MB) removal. The obtained cellulose beads were characterized using various analytical techniques. The results indicated that TEMPO-oxidized cellulose beads displayed porous structures with high content of carboxylic acid groups. Thus, the negatively charged cellulose beads can effectively adsorb cationic MB with an adsorption capacity of 495 mg/g at a starting concentration of 100 mg/L. This simple one-step adsorption process achieved near-complete MB removal at pH 7, indicating strong electrostatic interactions between cationic MB and negatively charged oxidized cellulose beads. The experimental data can be well described by the Langmuir isotherm model and the Pseudo-second-order model. The fabricated cellulose beads exhibit great potential for practical application in dye removal from wastewater.
Conflict at Work Impairs Physiological Recovery during Sleep: A Daily Diary Study

Sleep plays an essential role in maintaining employees’ health and well-being. However, stressors, such as conflict at work, may interfere with employees’ sleep. Drawing on previous literature on the relationship between conflict at work and sleep outcomes, we proposed a negative relationship between daily conflict at work and physiological changes during early sleep, particularly nocturnal heart rate variability (HRV). Furthermore, building on the perseverative cognition hypothesis, we proposed that daily work-related rumination mediates the relationship between conflict at work and nocturnal HRV. Ninety-three healthcare employees participated in a daily diary study for five workdays, resulting in 419 observations. Multilevel analysis revealed a significant relationship between daily conflict at work and nocturnal HRV, specifically high-frequency (HF) power. Daily conflict at work was found to predict rumination; however, rumination did not significantly predict nocturnal HRV. Our results suggest that daily conflict at work increases rumination during the off-job time and may directly alter nocturnal HRV, specifically parasympathetic function in early sleep.
Growth of monodisperse nanospheres of MnFe2O4 with enhanced magnetic and optical properties

Highly dispersive nanospheres of MnFe2O4 are prepared by template free hydrothermal method. The nanospheres have 47.3-nm average diameter, narrow size distribution, and good crystallinity with average crystallite size about 22 nm. The reaction temperature strongly affects the morphology, and high temperature is found to be responsible for growth of uniform nanospheres. Raman spectroscopy reveals high purity of prepared nanospheres. High saturation magnetization (78.3 emu/g), low coercivity (45 Oe, 1 Oe = 79.5775 A·cm−1), low remanence (5.32 emu/g), and high anisotropy constant 2.84 × 104 J/m3 (10 times larger than bulk) are observed at room temperatures. The nearly superparamagnetic behavior is due to comparable size of nanospheres with superparamagnetic critical diameter Dcrspam. The high value of Keff may be due to coupling between the pinned moment in the amorphous shell and the magnetic moment in the core of the nanospheres. The nanospheres show prominent optical absorption in the visible region, and the indirect band gap is estimated to be 0.98 eV from the transmission spectrum. The prepared Mn ferrite has potential applications in biomedicine and photocatalysis.
Rates and Determinants of Hospital-Acquired Infection among ICU Patients Undergoing Cardiac Surgery in Developing Countries: Results from EMERGENCY’NGO’s Hospital in Sudan

Introduction. Knowledge of local and regional antimicrobial resistance (AMR) is crucial in clinical decision-making, especially with critically ill patients. The aim of this study was to investigate the rate and pattern of infections in valvular heart disease patients admitted to the intensive care unit (ICU) at the Salam Centre for Cardiac Surgery in Khartoum, Sudan (run by EMERGENCY NGO). Methods. This is a retrospective, observational study from a single, large international referral centre (part of a Regional Programme), which enrolled patients admitted to the ICU between 1 January and 31 December 2019. Data collected for each patient included demographic data, operating theatre/ICU data and microbiological cultures. Results. Over the study period, 611 patients were enrolled (elective surgery n = 491, urgent surgery n = 34 and urgent medical care n = 86). The infection rate was 14.2% and turned out to be higher in medical than in surgical patients (25.6% vs. 12.4%; p = 0.002; OR = 2.43) and higher in those undergoing urgent surgery than those undergoing elective (29.4% vs. 11.2%; p = 0.004; OR = 3.3). Infection was related to (a) SOFA score (p < 0.001), (b) ICU length of stay (p < 0.001) and (c) days from ICU admission to OT (p = 0.003). A significant relationship between the type of admission (elective, urgent surgery or medical) and the presence of infections was found (p < 0.001). The mortality rate was higher among infected patients (infected vs. infection-free: 10.3% vs. 2.1%; p < 0.001; OR = 5.38; 95% CI: 2.16–13.4; p < 0.001). Conclusions. Hospital-acquired infections remain a relevant preventable cause of mortality in our particular population.
Non-linear mixed effect models for the relationship between fasting plasma glucose and weight loss.

Diabetes is one of the most common diseases in modern time. Its connection to overweight and obesity is well established, and diet and exercise are therefore important parameters in the treatment. A commonly used biomarker to diagnose and follow disease progression in diabetics is via measurements of fasting plasma glucose, FPG. In this study, the relationship between weight loss and FPG in overweight diabetics was studied. Competing hypothesis regarding the connection between weight loss and reduced FPG was investigated by using nonlinear mixed effects modeling based on data gathered from a meta-analysis by Anderson et al (1). The hypotheses suggested that either [1] weight effected FPG directly by an intermediate effector, or [2] both weight and FPG were affected by an unknown underlying mechanism. The intermediate effector was presumed to be insulin sensitivity and the underlying mechanism the blood concentration of free fatty acids. The data was gathered from 8 different studies, all examining the results of very low energy diets (330-909 kcal/day) in overweight type 2 diabetics. Frequent measurements of weight and FPG were provided in each study with a range of 91-321 mg/dl for baseline FPG and 93-118 kg for baseline weight. The summarized studies consisted of 13 arms with 6-62 subjects in each arm.Both hypotheses were modeled by using NONMEM 7.2. A stepwise effect was used for both weight and FPG. For hypothesis [1], an inhibitory effect affected the weight input which then affected the output for insulin sensitivity by a relative change in weight or the input for the insulin sensitivity by an absolute weight change. For hypothesis [2] the same inhibitory effect affected weight input and the input for insulin sensitivity. For both models the FPG drop was then proportional to the increase in insulin sensitivity. Hypothesis [2] had a significantly lower objective function value (OFV) than hypothesis [1] and had also better results from goodness of fit plots and VPCs. It was therefore concluded that hypothesis [2] indicated the more accurate explanation of the connection between FPG and weight loss. Moreover, a strong correlation between the caloric content of the diet and the rate of weight change was seen as a result of stepwise covariate modeling. An impact from baseline BMI on rate of change for insulin sensitivity was also seen.
Discerning the Role of Blood Brain Barrier Dysfunction in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common form of neurodegenerative disease. The predominant characteristics of AD are the accumulation of amyloid-β (Aβ) and hyperphosphorylated tau in the brain. Blood brain barrier (BBB) dysfunction as one of the causative factors of cognitive impairment is increasingly recognized in the last decades. However, the role of BBB dysfunction in AD pathogenesis is still not fully understood. It remains elusive whether BBB dysfunction is a consequence or causative fact of Aβ pathology, tau pathology, neuroinflammation, or other conditions. In this review, we summarized the major findings of BBB dysfunction in AD and the reciprocal relationships between BBB dysfunction, Aβ pathology, tau pathology, and neuroinflammation. In addition, the implications of BBB dysfunction in AD for delivering therapeutic drugs were presented. Finally, we discussed how to better determine the underlying mechanisms between BBB dysfunction and AD, as well as how to explore new therapies for BBB regulation to treat AD in the future.
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation

Obesity is a chronic metabolic disease caused by an imbalance between energy intake and expenditure during a long period and is characterized by adipose tissue disfunction and hepatic steatosis. The aim of this study was to investigate the effect of 4-methylesculetin (4-ME), a coumarin derivative, upon adipose microenvironment and hepatic steatosis in mice induced by a high-fat diet (HFD), and to explore potential mechanisms of its beneficial effect on metabolic disorders. HFD-fed mice displayed visceral obesity, insulin resistance, and hepatic lipid accumulation, which was remarkably ameliorated by 4-ME treatment. Meanwhile, 4-ME ameliorated adipocyte hypertrophy, macrophage infiltration, hypoxia, and fibrosis in epididymal adipose tissue, thus improving the adipose tissue microenvironment. Furthermore, 4-ME reversed the increase in CD36, PPAR-γ, SREBP-1, and FASN, and the decrease in CPT-1A, PPAR-α, and Nrf2 translocation into the nucleus in livers of HFD mice and in FFA-incubated hepatocytes. Moreover, the beneficial effects of 4-ME upon lipid deposition and the expression of proteins related to lipid metabolism in FFA-induced LO2 cells were abolished by ML385, a specific Nrf2 inhibitor, indicating that Nrf2 is necessary for 4-ME to reduce hepatic lipid deposition. These findings suggested that 4-ME might be a potential lead compound candidate for preventing obesity and MAFLD.
Contributions to the theory of Diophantine equations II. The Diophantine equation y2 = x3+k

This paper is a sequel to Part I (Baker 1968) in which an effective algorithm was established for solving in integers x, y any Diophantine equation of the type y) = m, where ^denotes an irreducible binary form with integer coefficients and degree at least 3. Here the algorithm is utilized to obtain an explicit bound, free from unknown constants, for the size of all the solutions of the equation. As a consequence of the cubic case of the result, it is proved that, for any integer 4= 9, all integers x, y satisfying the equation of the title have absolute values at most exp { (10101 A:|)10 }.
Magnetic Helicity, Dynamo Action, Reconnection, and Particle Acceleration

Blackman & Field have shown that a working α-Ω dynamo requires finite but opposite flows of small- and large-scale magnetic helicity through a body's surface. The helicity is accompanied by magnetic energy available for dissipation. The observed solar coronal nonthermal power is consistent with the derived lower limit required. This link between dynamo field generation and nonthermal emission should generally apply to stars, spiral galaxies, and accretion disks.
FGFR1–4 RNA-Based Gene Alteration and Expression Analysis in Squamous Non-Small Cell Lung Cancer

While fibroblast growth factor receptors (FGFRs) are involved in several biological pathways and FGFR inhibitors may be useful in the treatment of squamous non-small cell lung cancer (Sq-NSCLC), FGFR aberrations are not well characterized in Sq-NSCLC. We comprehensively evaluated FGFR expression, fusions, and variants in 40 fresh-frozen primary Sq-NSCLC (stage IA3–IV) samples and tumor-adjacent normal tissues using real-time PCR and next-generation sequencing (NGS). Protein expression of FGFR1–3 and amplification of FGFR1 were also analyzed. FGFR1 and FGFR4 median gene expression was significantly (p < 0.001) decreased in tumors compared with normal tissue. Increased FGFR3 expression enhanced the recurrence risk (hazard ratio 4.72, p = 0.029), while high FGFR4 expression was associated with lymph node metastasis (p = 0.036). Enhanced FGFR1 gene expression was correlated with FGFR1 protein overexpression (r = 0.75, p = 0.0003), but not with FGFR1 amplification. NGS revealed known pathogenic FGFR2,3 variants, an FGFR3::TACC3 fusion, and a novel TACC1::FGFR1 fusion together with FGFR1,2 variants of uncertain significance not previously reported in Sq-NSCLC. These findings expand our knowledge of the Sq-NSCLC molecular background and show that combining different methods increases the rate of FGFR aberrations detection, which may improve patient selection for FGFRi treatment.
Multiple Constant Sign and Nodal Solutions for Nonlinear Neumann Eigenvalue Problems

We consider a nonlinear Neumann eigenvalue problem driven by a possibly nonhomogeneous differential operator which incorporates as a special case the p-Laplacian. We assume that the right-hand side nonlinearity is (p − 1)-superlinear, but need not satisfy the Ambrosetti-Rabinowitz condition or to be monotone. We show that, for all values of the parameter λ in an upper half line, the problem has two positive and two negative solutions. Subsequently, for the case of the p-Laplacian, we also produce a nodal solution. Finally, for the semilinear case we show that the problem has two nodal solutions. Mathematics Subject Classification (2010): 35J25 (primary); 35J80, 58E05 (secondary).
Estimating Panel Time-Series Models with Heterogeneous Slopes

This article introduces a new Stata command, xtmg, that implements three panel time-series estimators, allowing for heterogeneous slope coefficients across group members: the Pesaran and Smith (1995, Journal of Econometrics 68: 79–113) mean group estimator, the Pesaran (2006, Econometrica 74: 967– 1012) common correlated effects mean group estimator, and the augmented mean group estimator introduced by Eberhardt and Teal (2010, Discussion Paper 515, Department of Economics, University of Oxford). The latter two estimators further allow for unobserved correlation across panel members (cross-section dependence).
Serological detection of adenovirus infection by ELISA in Fallujah city

Adenovirus represent the most common cause of respiratory system disorders and antibody detection can speed up and improve the sensitivity of hAdV diagnosis. Method: This study includes 90 patient who suffering from respiratory symptoms , common colds , or diarrhea with high temperature their ages range from newborn to elderly which collected from Fallujah Maternity and Children's Hospital and teaching hospital in Fallujah in Anbar governorate, for the period from November to May 1-11-2021 to 1-5-2022. Adenovirus was detected by ELISA Test for serum. Results: Out of total 90 serum sample there were 22(24.4%), 68(75.6%) Negative and positive result respectively, from IgG and 87(96.7%) ,3(3.3%) Ne gative and positive result respectively from IgM Result. Conclusion: The presence of positive IgM in ELISA cannot be relied upon as a tool for diagnosing early or acute infections with the virus.
Relationships between Social Networking Sites Use and Self-Esteem: The Moderating Role of Gender

With the prevalence of the internet, there is growing attention on the impacts of social networking sites use among adolescents. The purpose of this study was to explore the relationships between different types of online activities (i.e., information searching, social interaction and entertainment) and self-esteem. It examined whether the relationships vary across gender. One hundred and ninety-three students (57.5% males; Mage = 13.33, SDage = 1.58) participated in the present study. Unexpectedly, the associations between online activities and self-esteem were not significant (p > 0.05). Path analysis showed gender moderated the relationships between social interaction activities and self-esteem. Females reported higher levels of engagement in social interaction activities and self-esteem than their male counterparts. The present study shows the importance of assessing different types of online activities as a predictor for understanding the impact of social media use among adolescents.
Design and Performance Evaluation of a Novel Slave System for Endovascular Tele-Surgery

Vascular interventional robots have attracted growing attention in recent years. However, current vascular interventional robot systems generally lack force feedback and cannot quickly clamp the catheter/guidewire. The structure of slave systems is unstable and the power transmission is imprecise, increasing the system’s safety hazards. Vascular intervention robots generally do not follow traditional surgeons’ operation habits and, thus, it is not easy for them to understand and learn how to operate. Therefore, a novel vascular intervention system is proposed. The slave system can quickly clamp the catheter/guidewire, is compatible with various standard catheter/guidewire sizes, has precise power transmission, and has a stable structure. The surface of the catheter/guidewire is clamped without damage. Whether it is on the master side or the slave side, it follows the habits of traditional operators to a great extent. The results show that the measurement accuracy of the axial force meets the requirements of robot-assisted surgery and the system can track the designed position of the catheter/guidewire in real time. This study makes a certain contribution to the development of master–slave systems for endovascular tele-surgery.
CHEMICAL ENRICHMENT IN THE FAINTEST GALAXIES: THE CARBON AND IRON ABUNDANCE SPREADS IN THE BOÖTES I DWARF SPHEROIDAL GALAXY AND THE SEGUE 1 SYSTEM

We present an AAOmega spectroscopic study of red giants in the ultra-faint dwarf galaxy Boötes I (MV ∼ −6) and the Segue 1 system (MV ∼ −1.5), either an extremely low luminosity dwarf galaxy or an unusually extended globular cluster. Both Boötes I and Segue 1 have significant abundance dispersions in iron and carbon. Boötes I has a mean abundance of [Fe/H] = −2.55 ± 0.11 with an [Fe/H] dispersion of σ = 0.37 ± 0.08, and abundance spreads of Δ[Fe/H] = 1.7 and Δ[C/H] = 1.5. Segue 1 has a mean of [Fe/H] = −2.7 ± 0.4 with [Fe/H] dispersion of σ = 0.7 ± 0.3, and abundances spreads of Δ[Fe/H] = 1.6 and Δ[C/H] = 1.2. Moreover, Segue 1 has a radial-velocity member at four half-light radii that is extremely metal-poor and carbon-rich, with [Fe/H] = −3.5, and [C/Fe] = +2.3. Modulo an unlikely non-member contamination, the [Fe/H] abundance dispersion confirms Segue 1 as the least-luminous ultra-faint dwarf galaxy known. For [Fe/H] < −3.0, stars in the Milky Way's dwarf galaxy satellites exhibit a dependence of [C/Fe] on [Fe/H] similar to that in Galactic field halo stars. Thus, chemical evolution proceeded similarly in the formation sites of the Galaxy's extremely metal-poor halo stars and in the ultra-faint dwarf galaxies. We confirm the correlation between (decreasing) luminosity and both (decreasing) mean metallicity and (increasing) abundance dispersion in the Milky Way dwarf galaxies at least as faint as MV = −5. The very low mean iron abundances and the high carbon and iron abundance dispersions in Segue 1 and Boötes I are consistent with highly inhomogeneous chemical evolution starting in near zero-abundance gas. These ultra-faint dwarf galaxies are apparently surviving examples of the very first bound systems.