Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-Distance Pollen Dispersal in Urban Green Roof and Ground-Level Habitats

Long-distance pollen dispersal is critical for gene flow in plant populations, yet pollen dispersal patterns in urban habitats such as green roofs have not been extensively studied. Pollen dispersal patterns typically are assessed either by fitting non-linear models to the relationship between the degree of pollen dispersal and distance to the pollen source (i.e., curve fitting), or by fitting probability density functions (PDFs) to pollen dispersal probability histograms (i.e., PDF fitting). Studies using curve fitting typically report exponential decay patterns in pollen dispersal. However, PDF fitting typically produces more fat-tailed distributions, suggesting the exponential decay may not be the best fitting model. Because the two approaches may yield conflicting results, we used both approaches to examine pollen dispersal patterns in the wind-pollinated Amaranthus tuberculatus and the insect-pollinated Solanum lycopersicum at two green roof and two ground-level sites in the New York (NY, United States) metropolitan area. For the curve fitting analyses, the exponential decay and inverse power curves provided good fits to pollen dispersal patterns across both green roof and ground-level sites for both species. Similar patterns were observed with the PDF fitting analyses, where the exponential or inverse Gaussian were the top PDF at most sites for both species. While the curve fitting results are consistent with other studies, the results differ from most studies using PDF fitting, where long-distance pollen dispersal is more common than we observed. These results highlight the need for further research to compare curve and PDF fitting for predicting pollen dispersal patterns. And, critically, while long-distance pollen dispersal may be an important component of overall pollen dispersal for A. tuberculatus and S. lycopersicum in both urban green roof and ground-level sites, our results suggest it potentially may occur to a lesser extent compared with plants in less-urban areas.
Baicalin Induces a Potent Innate Immune Response to Inhibit Respiratory Syncytial Virus Replication via Regulating Viral Non-Structural 1 and Matrix RNA

Respiratory syncytial virus (RSV) infection is the most frequent cause of hospitalization in pediatric patients. Current systemic treatment and vaccines are not curative and re-infection is often associated with a more drastic incidence of the disease. Baicalin is a flavonoid isolated from Scutellaria baicalensis with potent anti-viral characteristics, namely against RSV. However, its precise mechanism of action remains unclear. Here, using in vitro methods and an in vivo murine model of RSV infection, we showed that baicalin inhibits RSV replication induces translational upregulation of type I interferons (IFNs), IFN-α and IFN-β, and reverses epithelial thickening in lung tissues. Moreover, baicalin inhibits transcription of the RSV non-structural proteins NS1 and NS2. Molecular docking and surface plasmon resonance-based affinity analysis showed that baicalin also binds to the α3 helix of the NS1 protein with an affinity constant of 1.119 × 10−5 M. Polysome profiling showed that baicalin inhibits translation of the RSV matrix protein (M) RNA. Baicalin mediates increased release of the ribosomal protein L13a from the large ribosomal subunit, where the extra ribosomal subunit L13a inhibits M RNA translation. These results comprehensively establish the multiple mechanisms by which baicalin induces a potent innate immune response against RSV infection.
The Scientific Method

The scientific method delivers prosperity, yet scientific practice has become subject to corrupting influences from within and without the scientific community. This essential reference is intended to help remedy those threats. The authors identify eight essential criteria for the practice of science and provide checklists to help avoid costly failures in scientific practice. Not only for scientists, this book is for all stakeholders of the broad enterprise of science. Science administrators, research funders, journal editors, and policymakers alike will find practical guidance on how they can encourage scientific research that produces useful discoveries. Journalists, commentators, and lawyers can turn to this text for help with assessing the validity and usefulness of scientific claims. The book provides practical guidance and makes important recommendations for reforms in science policy and science administration. The message of the book is complemented by Nobel Laureate Vernon L. Smith's foreword, and an afterword by Terence Kealey.
Systematic Review on Pathophysiological Complications in Severe COVID-19 among the Non-Vaccinated and Vaccinated Population

COVID-19, caused by SARS-CoV-2, is one of the longest viral pandemics in the history of mankind, which have caused millions of deaths globally and induced severe deformities in the survivals. For instance, fibrosis and cavities in the infected lungs of COVID-19 are some of the complications observed in infected patients post COVID-19 recovery. These health abnormalities, including is multiple organ failure—the most striking pathological features of COVID-19—have been linked with diverse distribution of ACE2 receptor. Additionally, several health complications reports were reported after administration of COVID-19 vaccines in healthy individuals, but clinical or molecular pathways causing such complications are not yet studied in detail. Thus, the present systematic review established the comparison of health complication noted in vaccinated and non-vaccinated individuals (COVID-19 infected patients) to identify the association between vaccination and the multiorgan failure based on the data obtained from case studies, research articles, clinical trials/Cohort based studies and review articles published between 2020–2022. This review also includes the biological rationale behind the COVID-19 infection and its subsequent symptoms and effects including multiorgan failure. In addition, multisystem inflammatory syndrome (MIS) has been informed in individuals post vaccination that resulted in multiorgan failure but, no direct correlation of vaccination with MIS has been established. Similarly, hemophagocytic lymphohistiocytosis (HLH) also noted to cause multiorgan failure in some individuals following full vaccination. Furthermore, severe complications were recorded in elderly patients (+40 years of age), indicates that older age individuals are higher risk by COVID-19 and post vaccination, but available literature is not sufficient to comply with any conclusive statements on relationship between vaccination and multiorgan failure.
Analysis of Radiation Treatment Planning Results for Prostate Cancer Treatment

Dosimetric plans generated on the same TPS may also vary depending on the experience of the treatment planner. Some planners are very skillful with in-depth knowledge of obtaining desired dose distributions, whereas some planners may be novice. Thus, it would be wise to compare the treatment plans done by the same planner instead of comparing the plan done by the experience planner against the plan done by the inexperience planner.
Trading Behavior in Agricultural Commodity Futures around the 52-Week High

Utilizing the Commodity Futures Trading Commission’s Commitment of Traders report, we examine the behavior of traders in three large agricultural futures markets (corn, soybean, and wheat) when prices are at a key technical trading level—the 52-week high (the highest price during the past year). Our empirical results confirm that, consistent with hedging behavior, commercial traders tend to be negative feedback traders, while non-commercial traders tend to be momentum traders. In both cases, there is a moderating effect when the market is at the 52-week high. For non-commercial traders, this effect is concentrated in short positions. Although we find no evidence of a broad market timing ability from any trader type, trader positions appear to be more informative when the market is at the 52-week high. Our results have implications for traders attempting to time market entry.
Which RHD alleles are risk factors stimulating allo-anti-D?

The aim of this study was to identify the specific RHD alleles that are risk factors for stimulating allo-anti-D and develop a precise strategy for blood transfusion. To confirm the D phenotype, red blood cells suspended in saline should react to serological anti-D from three manufacturers. An antibody screen test, a saline phase test and a micro-column test were conducted to identify allo-anti-D and other allo-antibodies. RHD alleles were geno-typed by PCR using sequence-specific primers. Seven hundred subjects who were either pregnant or had under-gone transfusion were enrolled in our study; however, 28 samples were excluded because their RHD alleles were normal, as revealed by tests using genotyping kits. A total of 498 cases (74.1%) were RHD- null (lacking exons 1-10 of RHD ), 336 were DEL RHD1227A (20.2%), and 38 were RHD - CE (2-9)- D (5.6%). There were 136 cases (20.2%) with allo-anti-D among the 672 cases, with an allo-anti-D prevalence of 126 cases (25.3%) in 498 cases that were RHD - null , followed by 10 cases (26.3%) among 38 cases with RHD-CE (2-9)- D , and none in 366 cases with RHD1227A . RHD genetic polymorphism was observed in RhD-negative individuals. We concluded that RHD-null and partial D are risk factors for alloimmunization to the D antigen and should be transfused with Rh-negative blood. RHD1227A recipients can be transfused with RhD-positive blood. Pregnant women with the d/d and D-CE (2-9)- D alleles require appropriate anti-D prophylaxis and RHD1227A may induce a higher tolerance. bilayer 12 times [2,3] . The N and C terminal domains are both located inside the cell [2,4-7] . Weak D, partial D, and Del types can be identified using serological anti-D kits, and genotyping of RHD has revealed that there are more alleles for the serological D-negative type than for the positive type. However, few studies have systemically examined the seroprevalence of allo-im-munization for RhD antigen among the different RHD alleles in China. This data may provide support for a national transfusion policy and RhD immunoglobulin prophylaxis for RhD-negative pregnant women.
Age-Related Differences in Amygdala Activation Associated With Face Trustworthiness but No Evidence of Oxytocin Modulation

The amygdala has been shown to be responsive to face trustworthiness. While older adults typically give higher face trustworthiness ratings than young adults, a direct link between amygdala response and age-related differences in face trustworthiness evaluation has not yet been confirmed. Additionally, there is a possible modulatory role of the neuropeptide oxytocin in face trustworthiness evaluation, but the results are mixed and effects unexplored in aging. To address these research gaps, young, and older adults were randomly assigned to oxytocin or placebo self-administration via a nasal spray before rating faces on trustworthiness while undergoing functional magnetic resonance imaging. There was no overall age-group difference in face trustworthiness ratings, but older compared to young participants gave higher trustworthiness ratings to ambivalently untrustworthy-looking faces. In both age groups, lower face trustworthiness ratings were associated with higher left amygdala activity. A comparable negative linear association was observed in right amygdala but only among young participants. Also, in the right amygdala, lower and higher, compared to moderate, face trustworthiness ratings were associated with greater right amygdala activity (i.e., positive quadratic (U-shaped) association) for both age groups. Neither the behavioral nor the brain effects were modulated by a single dose of intranasal oxytocin administration, however. These results suggest dampened response to faces with lower trustworthiness among older compared to young adults, supporting the notion of reduced sensitivity to cues of untrustworthiness in aging. The findings also extend evidence of an age-related positivity effect to the evaluation of face trustworthiness.
Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model

Capsid assembly modulators (CAMs) have emerged as a promising class of antiviral agents. We studied the effects of twenty-one newly designed and synthesized CAMs including heteroaryldihydropyrimidine compounds (HAPs), their analogs and standard compounds on hepatitis B virus (HBV) capsid assembly. Cytoplasmic expression of the HBV core (HBc) gene driven by the exogenously delivered recombinant alphavirus RNA replicon was used for high level production of the full-length HBc protein in mammalian cells. HBV capsid assembly was assessed by native agarose gel immunoblot analysis, electron microscopy and inhibition of virion secretion in HepG2.2. 15 HBV producing cell line. Induced fit docking simulation was applied for modelling the structural relationships of the synthesized compounds and HBc. The most efficient were the HAP class compounds—dihydropyrimidine 5-carboxylic acid n-alkoxyalkyl esters, which induced the formation of incorrectly assembled capsid products and their accumulation within the cells. HBc product accumulation in the cells was not detected with the reference HAP compound Bay 41-4109, suggesting different modes of action. A significant antiviral effect and substantially reduced toxicity were revealed for two of the synthesized compounds. Two new HAP compounds revealed a significant antiviral effect and a favorable toxicity profile that allows these compounds to be considered promising leads and drug candidates for the treatment of HBV infection. The established alphavirus based HBc expression approach allows for the specific selection of capsid assembly modulators directly in the natural cell environment.
The Right to Participate in Political and Decision-Making Process under the Maputo Protocol: Normative Masculinity and Nigerian Women

The birth of the Protocol on the Rights of Women in Africa otherwise known as Maputo Protocol was meant to overcome the shortcomings of the African Charter on Human Rights. Despite Nigeria’s ratification of the protocol, little concrete achievements have been recorded. This study situates the right of Nigerian women to participate in political and decision-making process under the Maputo Protocol in the context of normative and hegemonic barriers in the country. Using analytical methodology, the paper argues that the underrepresentation of Nigerian women in public governance is a negation of human rights. The domestication of the Protocol is recommended.
Entomological Surveillance of Aedes Mosquitoes: Comparison of Different Collection Methods in an Endemic Area in RIO de Janeiro, Brazil

Using collection methods for Aedes adults as surveillance tools provides reliable indices and arbovirus detection possibilities. This study compared the effectiveness of different methods for collecting Ae. aegypti and Ae. albopictus and detecting arboviruses circulating in field-caught female specimens. Collection sites were defined in urban, peri-urban, and rural landscapes in two Brazilian cities. Collections were performed using Adultraps (ADT), BG-Sentinel (BGS), CDC-like traps (CDC), and indoor (ASP-I) and outdoor (ASP-O) aspiration during the rainy and dry seasons of 2015 and 2016. Generalized linear mixed models were used to model the effectiveness of each collection method. A total of 434 Ae. aegypti and 393 Ae. albopictus were collected. In total, 64 Ae. aegypti and sixteen Ae. albopictus female pools were tested for DENV, CHIKV, ZIKV, or YFV; none were positive. Positivity and density were linear at low densities (<1 specimen); thereafter, the relationship became non-linear. For Ae. aegypti, ADT and CDC were less effective, and ASP-I and ASP-O were as effective as BGS. For Ae. albopictus, all collection methods were less effective than BGS. This study highlights the need for an integrated surveillance method as an effective tool for monitoring Aedes vectors.
Racialization of Serious Crime Arrestees: Who Does It and Does It Predict Worry about Victimization in Minority Neighborhoods?

Abstract Using data from two statewide surveys conducted in 2018 and 2020, this study explores the characteristics of adults who racialize serious crime arrestees and examines if racialization influences worry of victimization in minority neighborhoods. Results show a significant increase in perceptions of Whites as the largest portion of arrestees, suggesting a reduction in racialization. Those who do racialize serious crime arrestees were significantly more likely to express worry of victimization in predominantly Black or Hispanic neighborhoods. Our findings suggest the public lacks accurate information about arrests for serious crimes which may perpetuate stereotypes about minorities.
Potential Predictive Value of Serum Pentraxin 3 and Paraoxonase 1 for Cardiometabolic Disorders Development in Patients with Psoriasis—Preliminary Data

Psoriasis is a systemic disease that is linked to cardiometabolic complications. Paraoxonase 1 (PON1) exerts anti-atherogenic properties. Pentraxin 3 (PTX3) is related to heart failure and atherosclerosis. We aimed to evaluate the protein levels in psoriatic patients and explore possible relations with disease activity, metaflammation parameters and systemic treatment. Thirty-three patients with plaque-type psoriasis and eleven healthy controls were enrolled in the study. Blood samples were collected before and after three months of therapy with acitretin or methotrexate. Serum proteins levels were evaluated using Bio-Plex 200 System. The mean serum pentraxin 3 level was significantly higher in patients with psoriasis, compared to controls (p < 0.01). Significant negative correlations between PTX3 with triglycerides in overweight patients, with glucose, cholesterol and triglycerides in obese patients, and with cholesterol and triglycerides in severe psoriatics were noted (all p < 0.05). After the treatment, PTX3 significantly decreased (p < 0.05). The mean serum PON1 in psoriatic patients did not differ, compared to the controls (p > 0.05). In psoriatics of normal weight, PON1 correlated negatively with liver enzymes activity (p < 0.05). PTX3 might exert a protective role in terms of cardiometabolic disorders development, especially in overweight and obese or most severe psoriatics. PON1 could serve as an indicator of the liver disorders in psoriasis.
Effects of hydropower management on the sediment composition and metabolism of a small Alpine lake

The ecological equilibrium of water reservoirs may differ from that of natural lakes. We questioned this difference by analysing the sediments of a small oligotrophic Alpine lake, whose management was modified for hydroelectric production since 1976. Corne Lake is formed by a shallow depression connected to a deep depression. The hydropower management induced water level fluctuations (+2 m in summer; −8 m in winter) that emptied the shallow depression during the winter months and promoted the erosion of littoral soils and tributary channel sediment and the sedimentation in the deep depression. The sediment of the original lake was a low-density organic mud. The sediment composition varied according to 3 phases, which chronology is debated. During a first phase we measured an increase in the ratio of Diatom/Chrysophycea and bioavailable P, as well as a decrease in the C/N ratio and bulk radiocarbon age of the sediment, suggesting a trophic surge. A second phase was characterised by a high rate of mineral sedimentation, an increase of benthic diatom genera in the deep depression of the lake and acidophilic diatoms in the shallow depression. In the third phase covering the last upper cm of the cores, the sediment tended to return to its initial composition, but the algae community differed from its initial state. We suggest that the management of Alpine lakes as reservoirs induce long-term ecological changes in relation to water level fluctuations and littoral habitats degradation.
Challenges in using the graphics calculator in teaching statistics in a matriculation program

The teaching and learning of statistics has evolved tremendously over the years owing to the reformation in statistics education that changed the goals of statistics curriculum and the advancement of technology that revolutionized the pedagogy in statistics classrooms. On the whole, students’ knowledge acquisitions do not depend solely on the teacher anymore but students assume active roles in constructing knowledge with the correct guidance from the teacher. Moreover, with technological tools instead of concentrating on lengthy and repetitive calculations, students can focus in learning and understanding the important statistical concepts. Hand-held technologies such as the graphics calculators have paved the way for constructive and exciting learning experience. However, in developing countries such as Malaysia the use of graphics calculators in statistics classrooms poses challenges even to teachers and instructors of statistics.
Applying directional upper semi-regular convexificators in bilevel optimization

In this paper, following the optimistic approach in bilevel programming, we investigate necessary and sufficient optimality conditions for a bilevel optimization problem. Our approach consists of using the optimal value reformulation together with an exact penalization technique. Unlike Dempe and Pilecka (Journal of Global Optimization 61: 769–788, 2015), we reach our goal without resorting to convexificators; the reason is that we do not assume that the sets of all continuity directions are convex or closed. The obtained results are given in terms of directional upper semi-regular convexificators. Some examples are given to illustrate our results.
Maternal Health Literacy, Health information‐seeking Behavior and Pregnancy Outcomes Among Iranian Pregnant Women: A Cross-Sectional Study

Background: Maternal health literacy (MHL) and health information-seeking behavior (HISB) could impact maternal health and pregnancy outcomes. Purpose and Research Design: This cross-sectional study investigated MHL, HISBs, and pregnancy outcomes in Iranian pregnant women. This study was also aimed to determine the predictors of MHL and pregnancy outcomes. Study smple and Data Collection: In this study, 337 randomly selected postpartum women completed three questionnaires, including a demographics form, an obstetrics history checklist, and the Maternal Health Literacy and Pregnancy Outcome Questionnaire (MHLAPQ). Results: The mean MHL and pregnancy outcome scores were 60.80 ± 9.91 and 49.88 ± 5.69, respectively. Of the participants, 56% adopted both formal and informal HISB. Education and internet HISB was associated with the odds of being in the group with higher MHL. Participants with high MHL had more than twice higher odds for better pregnancy outcomes (OR = 2.25, p < 0.004). Conclusions: Continued efforts are required to make health information sources more accessible to pregnant women to improve their health literacy and pregnancy outcomes.