Miracle-dz/UniFAR-FTUs huggingface dataset:
Online Resource for Integrative Omics ) : a web-based platform for rapid integration of next generation sequencing data

Established and emerging next generation sequencing (NGS)-based technologies allow for genomewide interrogation of diverse biological processes. However, accessibility of NGS data remains a problem, and few user-friendly resources exist for integrative analysis of NGS data from different sources and experimental techniques. Here, we present Online Resource for Integrative Omics (ORIO; https: //orio.niehs.nih.gov/), a web-based resource with an intuitive user interface for rapid analysis and integration of NGS data. To use ORIO, the user specifies NGS data of interest along with a list of genomic coordinates. Genomic coordinates may be biologically relevant features from a variety of sources, such as ChIPseq peaks for a given protein or transcription start sites from known gene models. ORIO first iteratively finds read coverage values at each genomic feature for each NGS dataset. Data are then integrated using clustering-based approaches, giving hierarchical relationships across NGS datasets and separating individual genomic features into groups. In focusing its analysis on read coverage, ORIO makes limited assumptions about the analyzed data; this allows the tool to be applied across data from a variety of experiments and techniques. Results from analysis are presented in dynamic displays alongside usercontrolled statistical tests, supporting rapid statistical validation of observed results. We emphasize the versatility of ORIO through diverse examples, ranging from NGS data quality control to characterization of enhancer regions and integration of gene expression information. Easily accessible on a public web server, we anticipate wide use of ORIO in genomewide investigations by life scientists.
0 Customer Concentration , Cost Structure , and Performance

This study examines the effects of customer concentration levels on firm cost structure decisions. Analyzing cost data from a sample of manufacturing firms from 1976 through 2013, we find a negative relationship between customer concentration and cost elasticity whereby firms exhibit lower proportions of variable-tofixed costs in the presence of higher levels of customer concentration. Additionally, we find that greater customer bargaining power, proxied by supplier industry competition and product market fluidity, leads to lower cost elasticity as customer concentration becomes greater. These results are robust to alternate specifications as well as controlling for endogeneity using a two-stage model. Our results suggest that suppliers respond to customer concentration by pursuing increased mutual dependence and cooperation with customers rather than attempting to reduce the effect of power imbalances within the supplier-customer relationship.
Chapter 23 : Amadeus Basin Geology and mineral resources of the Northern Territory

s, 304. Orogen, east Kimberley region (1:500 000 scale): in (editors) ‘Geology of the King Leopold and Halls Creek Orogens’ Western Australia Geological Survey, Bulletin 143. Tyler IM and Hocking RM, 2001. A revision of the tectonic units of Western Australia. Geological Survey of Veevers JJ, 1976. Early Phanerozoic events on and alongside the Australasian-Antarctic Platform. Journal of the Geological Society of Australia 23, Walley AM, Cook PJ, Bradshaw J, Brakel AT, Kennard JM, Lindsay JF, Nicoll RS, Olissoff S, Owen M, Shergold JH, Totterdell JM and Young GC, 1991. The Palaeozoic palaeogeography of the Amadeus Basin region: in Korsch RJ and Kennard JM (editors) ‘Geological and geophysical studies in the Amadeus Basin, central Australia’. Bureau of Mineral Resources, Australia, Bulletin Wakelin-King G, 1994. Proterozoic play challenges Amadeus Basin explorers. Oil and Gas Journal 92, Wakelin-King G and Austin L, 1992. Magee 1, EP 38, Oil & Gas Ltd. Northern Territory Geological Survey, Open File Petroleum Report PR1992-0121. Walter MR, 1972. Stromatolites and the biostratigraphy of the Australian Precambrian and Cambrian. Special Papers in Palaeontology Walter MR, 1980. Adelaidean and early Cambrian stratigraphy of the southwestern Georgina Basin, Australia: correlation chart and explanatory notes. Bureau of Mineral Resources, Australia, Report 214; BMR Microform MF92. Walter MR, Krylov IN and Priess WV, 1979. Stromatolites from Adelaidean (Late Proterozoic) sequences in central and South Australia. Alcheringa Geology and mineral resources of the Northern Territory Special publication 5
Experimental Study of the Performance of Bare and Nozzle – Diffuser Shrouded Micro Wind Turbine under axial and non-axial Inflow Condition

Shrouding (diffuser augmented) horizontal axis micro-wind turbine has been shown to be an effective ways to improve the performance of micro wind turbine. The paper reports experimental work on the effects of shroud/diffuser shape and geometry on the turbine performance. Three different diffuser shapes: straight diffuser, nozzle-diffuser combination, and diffuser-brim (brimmed diffuser) combination have been investigated. Tests confirmed that placing micro wind turbine model inside a diffuser can substantially improve its performance. Straight diffuser improves the performance by 56% compared to the bare turbine whilst the nozzle-diffuser enhancement of 61% is slightly better than diffuser only. Increasing the diffuser length does not improve the turbine performance but adding brim at the exit plane of the diffuser does. The effect of non-axial inflow on the model wind turbine was also investigated. Non-axial inflow decreases the coefficient of performance of the turbine. The finding from this work demonstrates that shrouding micro wind turbine not only improves the performance but also demonstrates how diffuser geometrical features diffuser length, brim height and nozzle addition can be used to design high performance turbine to suit wind condition at location. Further testings and optimisations could lead to the realisation of optimal augmentation for micro wind turbine, which would have great implications for wind power extraction in built environment.
THE HIDDEN ROLE OF “BUY-IN”: HOW FACULTY AND STUDENT ATTITUDES IMPACT CURRICULAR REFORM

Vision & Change recommends transformation in undergraduate biology education, but some faculty may be reluctant to reform their courses for fear of student resistance, or a perception that such change is unnecessary. This student resistance may arise because of an unfamiliarity with an active-learning environment, or from non-STEM students who believe they are disadvantaged in a mixed-majors introductory biology course. Faculty may use many measures to evaluate the extent of student resistance, such as student evaluations of teaching or verbal comments from students or colleagues. It is less common for faculty to use a thorough assessment of both student learning gains and self-efficacy to inform curricular change. We assessed both of these measures in a mixed-majors biology course at a small liberal arts college. Students self-reported increases in learning gains on surveys, and preand post-course concept assessment demonstrated actual learning and performance gains. Because we found that STEM majors were more likely to report positive opinions than non-STEM majors, we suggest that offering a non-majors introductory biology course may be more successful in engaging these students. Overall, we found that positive student opinions were more frequent than negative opinions regardless of major; we conclude that student resistance was much less than some faculty expected. Without a thorough use of assessments, the extent of positive student opinions may not become apparent, and a disproportionate bias toward negative opinions may instead drive curricular decisions.
Expanding direction-of-comparison theory and its applications for political advertising practitioners

The authors expand direction-of-comparison theory by exploring the cancellation and focus model of decision choice in new media environments. The findings in these environments are then compared with existing findings from previous studies that utilized print media stimuli. The similarities and differences are then discussed. The implications of this study on comparative political advertising campaigns are given, with specific suggestions on how political advertising practitioners can utilize this new decision-making information. This can result in creation of better and more productive comparative advertisements within their campaigns. Past research has shown the effectiveness of comparative political advertising on an audience that currently supports a specific candidate. This study expands knowledge in this area by offering research findings that suggest these comparative ads, if set up correctly, can be effective on those audience members who have not yet made up their mind, or who see the political candidates as essentially equal.
An application of Wavelet analysis to fractal character of Indian Dipole Mode

In this study, short-term climatic transitions within Quasi-Biennial (QB) cycles are considered “noise” for El Niño/Southern Oscillation (ENSO). The noise characteristic is represented by the Hurst coefficient H. Fractal dimension analysis and stochastic resonance (SR) are adopted to cope with the roles of noise for ENSO. The oscillation of H of Nino3.4 SST mostly corresponded with the development of El Niño, particularly during two strong Tropical Pacific Decadal Oscillation (TDO) periods of 1894 to 1923 and 1978 to 2000. This represents a stochastic resonance mechanism in the internal Pacific oceanatmospheric system that is when a positive-phase noise overlaps with a stronger positive-phase TDO, SST easily exceed the critical state to launch an El Niño. This mechanism gives the condition whereby the onset of El Niño is more sensitive to noise. IOD and noise in DMI (high frequencies of IOD) are two external triggers of ENSO and affect ENSO through the SR mechanism. Phase-lead is an important feature as a trigger in an SR system. When the noise in DMI leads (lags) noise in a Niño3. 4 SST, the correlation between IOD and ENSO increases (decreases) after 1910s. SR explains how external noise set out an El Niño. Noise in DMI 2 influencing ENSO progressively advances from that of DMI, after the 1930s.
UvA-DARE ( Digital Academic Repository ) A heterodimer of the Zn 2 Cys 6 transcription factors Pip 2 p and Oaf 1 p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae

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Dedicated to Professor A. M. Vershik on his 70th birthday TRANSVERSE PROPERTIES OF DYNAMICAL SYSTEMS

Roughly speaking, two dynamical systemes are transversally equivalent if they have the same space of orbits; a property is transverse if it is preserved under transverse equivalence. Various notions of transverse equivalence have been defined: among them, similarity of measured groupoids, Morita equivalence of locally compact groupoids, stable orbit equivalence of measure equivalence relations. After reviewing some of these notions, my talk will be about Morita equivalence of groupoids and will give examples and applications, in particular in connection with operator algebras.
Title Defective adipose tissue development associated with hepatomegaly incathepsin E-deficient mice fed a high-fat diet

Cathepsin E is an intracellular aspartic proteinase, which is predominantly distributed in immune-related and epithelial cells. However, the role of the enzyme in adipose tissues remains unknown. In this study, we investigated the characteristics of cathepsin E-deficient (CatE-/-) mice fed a high-fat diet (HFD), as a mouse model of obesity. HFD-fed CatE-/mice displayed reduced body weight gain and defective development of white adipose tissue (WAT) and brown adipose tissue (BAT), compared with HFD-fed wild-type mice. Moreover, fat-induced CatE-/mice showed abnormal lipid accumulation in non-adipose tissues characterized by hepatomegaly, which is probably due to defective adipose tissue development. Detailed pathological and biochemical analyses showed that hepatomegaly was accompanied by hepatic steatosis and hypercholesterolemia in HFD-induced CatE-/mice. In fat-induced CatE-/mice, the number of macrophages infiltrating into WAT was significantly lower than in fat-induced wild-type mice. Thus, the impaired adipose tissue development in HFD-induced CatE-/mice was probably due to reduced infiltration of macrophages and may lead to hepatomegaly accompanied by hepatic steatosis and hypercholesterolemia. Abbreviations CatE-/-, cathepsin E-deficient; ND, normal diet; HFD, high-fat diet; CHO, cholesterol; LDL, low density lipoprotein; SAA, serum amyloid A; white adipose tissue, WAT; brown adipose tissue, BAT
Multifaceted companion devices: applying the new model of media attendance to smartphone usage

This study inspects the relationship between outcome expectations, habit strength, and smartphone usage by attempting to validate the new model of media attendance (NMMA) (LaRose and Eastin, 2004) , a social-cognitive theory of uses and gratifications. The fast adoption rate of smartphones, and their inherent characteristics as convergent, always-on, always-connected devices, warrant a closer look into user habitualization of this medium. Using a sample of 481 smartphone users selected from a larger panel, we were able to support the NMMA, although surprisingly no significant effect of habit strength on smartphone usage was found. While some uncertainties connected to the method are noted, this suggests a more complex reality, in which habitualization of a convergent media device does not necessarily implicate a significant rise in usage.
An Ediacaran opportunist? Characteristics of a juvenile Dickinsonia costata population from Crisp Gorge, South Australia

Abstract. Despite 70 years of study, Dickinsonia remains one of the Ediacara biota's most enigmatic taxa with both morphological characters and phylogenetic affinities still debated. A large population of relatively small Dickinsonia costata present on a semi-contiguous surface from the Crisp Gorge fossil locality in the Flinders Ranges (South Australia) provides an opportunity to investigate this taxon in its juvenile form. This population supports earlier findings that suggest D. costata's early growth was isometric, based on the relationship between measured variables of length and width. The number of body units increases with length, but at a decreasing rate. A correlation between a previously described physical feature, present as a shrinkage rim partially surrounding some specimens and a novel, raised lip in some specimens, suggests that both features may have been the result of a physical contraction in response to the burial process, rather than due to a gradual loss of mass during early diagenesis. A marked protuberance in 15% of the population is also noted in limited specimens within the South Australian Museum collections and appears to be present only in juvenile D. costata. Both the abundance and narrow size range of this population support the notion that Dickinsonia was a hardy opportunist, capable of rapid establishment and growth on relatively immature textured organic-mat substrates.
Outcomes of Roux-enY gastric bypass surgery for severely obese patients with type 1 diabetes : a case series report

Correspondence: Robert J Tanenberg East Carolina University, 600 Moye Blvd 3E-129, Greenville, NC 27834, USA Email tanenbergr@ecu.edu Abstract: Roux-en-Y gastric bypass surgery (RYGB) reverses type 2 diabetes (DM2) in approximately 83% of patients with morbid or severe obesity. This procedure has been performed in small numbers of severely obese patients with type 1 diabetes (DM1), but the impact on glycemic control and insulin requirement in this population has not been widely described. We report three patients with DM1 and severe obesity that underwent RYGB. Weight, glycemic control, and insulin requirements before and one year after the procedure were compared. Significant weight loss was achieved by all three patients but insulin requirements decreased in only 2 patients. In contrast, glycemic control (A1C) remained suboptimal in all three patients up to one year after the surgery. These findings suggest that RYGB leads to important weight loss and positively affects insulin sensitivity. However, reaching optimal glycemic control in patients with DM1 diabetes remains challenging due to persisting insulin deficiency.
DEVELOPMENT OF BEGINNING SKILLS IN PROVING AND PROOF-WRITING BY ELEMENTARY SCHOOL STUDENTS

This paper presents the results of a study regarding the development of deductive reasoning among elementary school students. We have experienced a sequence of 8 teaching and learning lessons in order to develop their primary skills of writing proof in a geometrical context. This sequence, over a 4 months period, was tested with two classes of 26 students aged 11-12 from a single school in Quebec (Canada). Results showed an important increase in most of the students, between the beginning and the end of the sequence, in their ability to reason deductively and validate geometric statements by using theoretical properties rather than measurement.
Toroidal field r ipple effects on H-modes in JET and implications for ITER

G Saibene , R Sartori, P de Vries, A Loarte, J Lönnroth, V Parail(2), A Salmi (3) , PR Thomas (4) , P Andrew (2) , Y Andrew (2) , R Budny (5) , A Boboc (2) , I Coffey (2) , E de la Luna (6) , PJ Lomas (2) , S Gerasimov (2) , C Giroud (2) , J Hobirk (7) , S Hotchin (2) , T Johnson (8) , C Lescure (2) , DC McDonald (2) , I Nunes (9) , N Oyama (10) , V Riccardo (2) , H Urano (10) , and JET EFDA contributors (*)
Faraday instability on a sphere: numerical simulation

We consider a spherical variant of the Faraday problem, in which a spherical drop is subjected to a time-periodic body force, as well as surface tension. We use a full three-dimensional parallel front-tracking code to calculate the interface motion of the parametrically forced oscillating viscous drop, as well as the velocity field inside and outside the drop. Forcing frequencies are chosen so as to excite spherical harmonic wavenumbers ranging from 1 to 6. We excite gravity waves for wavenumbers 1 and 2 and observe translational and oblate–prolate oscillation, respectively. For wavenumbers 3 to 6, we excite capillary waves and observe patterns analogous to the Platonic solids. For low viscosity, both subharmonic and harmonic responses are accessible. The patterns arising in each case are interpreted in the context of the theory of pattern formation with spherical symmetry.
P ROPERTIES OF THE SCUBA-2 850 μ m S OURCES IN THE AKARI NEP-D EEP F IELD

We carry out a study of Sub-Millimeter Galaxies (SMGs) in the AKARI NEP-Deep field using the James Clerk Maxwell Telescope (JCMT) SCUBA-2 850 μm source catalog, released as part of the SCUBA-2 Cosmology Legacy Survey (S2CLS) program. The SCUBA-2 850 μm map has a root mean square (rms) noise of 1.2 mJy beam and covers an area of 0.60 degree. We find four SMGs which have counterparts to Herschel sources with spectroscopic redshifts in the literature. In addition, three dust obscured galaxies (DOGs) detected in Herschel bands are selected as a comparison sample. We derive IR luminosities of SMGs using the CIGALE code, which are similar to those of high redshift SMGs from previous studies. The contribution of AGN to the total IR luminosity in SMGs (2%–11%) is smaller than the lower limit for the one in DOGs (19%–35%), which is consistent with the expectation from the evolutionary scenario of massive galaxies. We search for SMGs in overdense regions as protocluster candidates and investigate four regions, including candidates around three DOGs. Finally, we argue that follow-up spectroscopic observation for the NEP-Deep field will provide crucial information to understand the role of SMGs in the evolution of massive galaxies.
Estimation of peak electron density in upper ionosphere of Mars at high latitude (50°–70°N) using MGS ACC data

Under photochemical equilibrium condition, electron density near peak varies as the square root of total peak ionization rate. Thus by averaging the longitudinal variation of latter, the mean primary and secondary peak electron densities in upper ionosphere of Mars using measured mass densities at LST 16 hrs are estimated to be ∼8.56 × 104 cm−3 and ∼1.81 × 104 cm−3. On comparison with mean electron densities at LST 3–4 hrs for observational period Dec. 24–31, 1998, at same solar zenith angle, it is found that the estimated primary peak electron density at LST 16 hrs is more by a factor of ∼1.06. With this analogy, the estimated secondary peak electron density should be ∼3.76 × 104 cm−3 instead of ∼1.81 × 104 cm−3. Thus, in order to obtain the estimated secondary peak electron density of ∼3.76 × 104 cm−3, soft X‐ray flux should be increased by a factor of ∼4.31.
A Study on Acute Symptomatic Seizures Following Stroke in a Tertiary Care Centre

AIM: To study the clinical and etiological profile of 130 consecutive patients with acute symptomatic seizures following stroke presenting to a tertiary care centre in south India. BACKGROUND: Post stroke seizures are defined as those at the beginning of or after stroke in a patient without prior onset of seizures. They are classified as acute symptomatic seizures(ASS) and Unprovoked seizures(US) depending on the time of occurrence with respect to the onset of stroke.The ILAE defines ASS if they occur within 7 days of stroke and US if seizures manifest after 1 week.Semiology could be focal seizures,focal with secondary generalization and generalized tonic clonic seizures. MATERIALS AND METHODS:130 consecutive patients with acute symptomatic seizures admitted in the Department of Neurology, Madras Medical College were included in the study after obtaining informed consent.After enrolment into the study based on the inclusion and exclusion criteria,a pre designed questionnaire was filled with information regarding demographic details,clinical features,type and size of stroke based on imaging and EEG patterns.RESULTS:Mean age of all patients was 52.4 years ranging from 32 years to 86 years.Out of 130 patients 93 were males and 37 were females . 97 patients had seizures within the first 24 hours.86(66%) patients had ischemic stroke, out of which 65 were cortical and 21 were subcortical.Total of 33(26%) patients had ICH -14 had lobar haemorrhage and 19 had ganglionic bleed.11(8%) patients had cerebral infarct with hemorrhagic transformation. With regard to semiology of seizures 72(55%) had focal,40(31%) had focal with secondary generalisation,13(10%) had generalised tonic clonic seizures and 5(4%) had status epilepticus.EEG recordings were normal in 44(34%) patients,showedfocal slowing in 38(29%),diffuse slowing in 32(25%) and epileptiform discharges in 16(12%) patients.Out of the total 130 patients 52(40%) had single seizures and 78(60%) had multiple seizures.Only 4(3%) out of 130 patients had recurrent seizures. CONCLUSION: In our study patients with ischemic stroke presented with acute symptomatic seizures more commonly compared to ischemic stroke with hemorrhagic transformation and Intracerebral hemorrhage . Cortical site and larger size had more percentage of seizures compared to the subcortical site and smaller size in both ischemic and hemorrhagic stroke.Focal seizures with or without secondary generalization were found to be the commonest semiology. However there was no specific EEG pattern correlating to recurrence of seizures nor did it make any difference to the management of the patient.