Miracle-dz/UniFAR-FTUs huggingface dataset:
Reconciling data on the trends and abundance of North Atlantic humpback whales within a population modelling framework

Populations of humpback whales (Megaptera novaeangliae) in the North Atlantic appear to have been increasing at least during the last few decades, following the cessation of substantial hunting almost 100 years ago. Several sources of data are available for these populations (survey and mark-recapture estimates of absolute and relative abundance, estimated catches, and estimates of the proportion of the animals on two feeding grounds that are from the West Indies breeding ground). These data were analysed using an age- and sex-structured population dynamics model that is spatially-explicit to the extent that abundance is tracked on five feeding and two breeding grounds. Several alternative hypotheses, including depensation and changes over time in carrying capacity, were captured within the model framework. Two scenarios form the focus of the analyses, based on alternative interpretations of the size of the breeding population off the Cape Verde Islands. The results of these analyses confirm the increase in the number of humpback whales in the North Atlantic, although it is not possible to determine the extent of such increases. Whether both the West Indies and Cape Verde Islands breeding stocks have increased depends on whether the estimate of abundance for the Cape Verde Islands population of approximately 100 animals is valid. Although many of the data sources can be reconciled given the model applied, some conflicts remain; resolution of these conflicts will require collection of additional data.
Modelling Disease progression of Multiple Sclerosis in a South Wales Cohort

Objectives: To model multiple sclerosis (MS) disease progression and compare disease trajectories by sex, age of onset, and year of diagnosis. Study Design and settings: Longitudinal EDSS scores were collected since 1985 for relapse-onset MS patients at MS clinics in South Wales and modelled using a multilevel model (MLM). The MLM adjusted for baseline covariates (sex, age of onset, year of diagnosis, and disease modifying treatments (DMTs)), and included interactions between baseline covariates and time variables. Results: The optimal model was truncated at 30 years after disease onset and excluded EDSS recorded within 3 months of relapse. As expected, older age of onset was associated with faster disease progression at 15 years (effect size (ES): 0.75; CI: 0.63, 0.86; P: <0.001) and female sex progressed more slowly at 15 years (ES: -0.43; CI: -0.68, -0.18; P: <0.001). Patients diagnosed more recently (defined as 2007-2011 and >2011) progressed more slowly than those diagnosed historically (<2006); (ES: -0.46; CI: -0.75, -0.16; P: 0.006) and (ES: -0.95; CI: -1.20, -0.70; P: <0.001), respectively. Conclusion: We present a novel model of MS outcomes, accounting for the nonlinear trajectory of MS and effects of baseline covariates, validating well-known risk factors (sex and age of onset) associated with disease progression. Also, patients diagnosed more recently progressed more slowly than those diagnosed historically.
Exposure to pyriproxyfen pesticide (juvenile hormone agonist) does not alter maternal care and reproduction in the European earwig

Sublethal exposure to pesticides can alter the survival and reproduction of a wide range of non-target organisms. However, it remains unclear whether this exposure can alter behaviours that are often essential for long-term population dynamics and maintenance, such as parental care. In this study, we tested the effect of pyriproxyfen exposure (an insect growth regulator) on maternal care in the European earwig, an insect that is both used in pest control in pip-fruit orchards and considered a pest in stone fruit orchards. We exposed 424 females at doses either 10 times lower, equivalent or 10 times higher than normal application rates in French orchards. As maternal care can change over the weeks of family life, we exposed the earwig mothers at five different days before and after egg hatching. We then measured the expression of ten forms of maternal care towards eggs and juveniles, six non-caring behaviours, eggs and juveniles development, metabolic reserves in mothers at egg hatching and females’ production of a terminal clutch. First, our results revealed that the three tested doses of pyriproxyfen were non-lethal and confirmed that maternal care decreased throughout both pre-and post-hatching family life. However, we did not detect any effect of pyriproxyfen on maternal care and non-care behaviours, eggs and juveniles development, quantities of lipids, proteins and glycogen in mothers at egg hatching, and on the production of a future clutch. Overall, these findings suggest that the maximal doses of pyriproxyfen authorized in French orchards is likely to have limited effects on the short-and long-term maintenance of populations of the European earwig, and raises fundamental questions about the nature of the link between juvenile hormone and parental care in insects.
Benefits of the Polypill on Medication Adherence in the Primary and Secondary Prevention of Cardiovascular Disease: A Systematic Review

Background Higher medication adherence reduces the risk of new cardiovascular events. However, there are individual and health system barriers that lead to lower adherence. The polypill has demonstrated benefits in cardiovascular morbidity and mortality mainly driven by an increase in adherence. We aim to evaluate the impact of the polypill on adherence to cardiovascular medication, its efficacy and safety in cardiovascular disease (CVD) prevention. Methods A systematic review following PRISMA guidelines was conducted. Databases were searched from January 2003 to December 2022. We included randomized, pragmatic, or real-world clinical trials and observational studies. The primary outcome was medication adherence, secondary outcomes were efficacy in cardiovascular disease in primary and secondary prevention and safety. Results From the 490 publications screened, 13 met the inclusion criteria and were incorporated into a comparative table Of those included, 70% were randomized controlled trials (RCTs) and 53.8% focused on secondary prevention. Most of the studies received a high and moderate quality rating. Self-report, pill counting and, the Morisky scale were the most frequent methods to evaluate adherence (84.6%). Compared with standard medication, the polypill improved overall medication adherence by 13%, with percentages ranging from 7.6% to 34.9%. Moreover, a potential benefit was also observed in reducing Major Adverse Cardiovascular Events (MACE), particularly in secondary prevention studies, with hazard ratios ranged between 0.43 to 0.76. Compared to standard care, the profile of side effects was similar. Conclusion The polypill is an effective, safe, and practical strategy to improve adherence in people at risk of CVD. Although there is a demonstrated benefit in reducing MACE, predominantly in secondary prevention, there are still gaps in its efficacy in primary prevention and reducing total mortality. Therefore, the importance of obtaining long-term results of the polypill effect and how this strategy can be implemented in real practice.
Cutaneous irritancy of an ibuprofen medicated plaster in healthy volunteers

ABSTRACT Objectives: To assess the irritation and contact sensitization potential of a 200 mg ibuprofen medicated plaster. Methods: This double-blind, phase-1 placebo controlled study had two phases; the induction phase to evaluate the irritant potential of continuous application of the plaster, and the challenge phase to assess contact sensitivity (allergy). The cumulative irritancy potential was evaluated using an adaptation of the Shelanski method. Healthy adults (≥18 years of age) (N = 210) were treated simultaneously with one ibuprofen medicated and one placebo plaster applied in a randomized fashion to either the left or right side of the lower back. During the induction phase, plasters were applied on Days 1, 3, 5, 8, 10, 12, 15, 17, and 19 and the final plaster removed on Day 22. At each scheduled visit plasters and applications sites were assessed for degree of adhesion and skin irritation (score of 1 = no irritation to 7 = strong reaction spreading beyond test sites), respectively. The challenge phase followed a two-week washout period. A plaster was applied on Day 36 for 48 h and assessment occurred on Days 38, 39, and 40. Results: The mean cumulative irritation score during the induction phase was lower for the ibuprofen medicated plaster than the placebo plaster (0.32 vs. 1.23, respectively). Three (1.4%) subjects experience a dermal reaction of grade ≥3 for the ibuprofen medicated plaster compared with 27 (12.7%) for the placebo plaster. Following challenge with ibuprofen or placebo plasters, 12 subjects (6.2%) with the ibuprofen medicated plaster and four (2.2%) with the placebo plaster had skin reaction of assessment grade higher than the induction phase. One subject for the ibuprofen and two for the placebo plaster had reactions with grade >2. No subjects showed an increase in sensitization on Day 39 or 40 compared with Day 38. Conclusions: The findings indicate that the both the irritancy and contact sensitization of the ibuprofen medicated plaster is acceptable.
Polarization Properties of Coherently Superposed Rayleigh Backscattered Light in Single-Mode Fibers

The properties of the state of polarization (SOP) and the degree of polarization (DOP) of Rayleigh backscattered light (RBL) in single-mode fibers (SMF) are investigated theoretically and experimentally when the incident probe is a perfectly coherent continuous-wave (CW) light. It is concluded that the instantaneous DOP of the coherently superposed RBL is always 100%, and the instantaneous SOP is determined by the distributions of the birefringence and the optical phase along the SMF. Therefore, the instantaneous SOP of the coherently superposed RBL does not have a constant relationship with the SOP of the incident CW probe. Furthermore, the instantaneous SOP varies randomly with time because the optical phase is very sensitive to ambient temperature and vibration even in the lab environment. Further theoretical derivation and experimental verification demonstrate, for the first time, that the temporally averaged SOP of the coherently superposed RBL has a simple constant relationship with the SOP of the incident CW probe, and the temporally averaged DOP is 1/3 in an SMF with low and randomly distributed birefringence. The derived formulas and obtained findings can be used to enhance the modelling and improve the performances of phase-sensitive optical time-domain reflectometry and other Rayleigh backscattering based fiber-optic sensors.
University of Birmingham Linear programming approach to optimal impulse control problems with functional constraints

This paper considers an optimal impulse control problem of dynamical systems generated by a ﬂow. The performance criteria are total costs over the inﬁnite time horizon. Apart from the main performance to be minimized, there are multiple constraints on performance functionals of a similar type. Under a natural set of compactness-continuity conditions on the system primitives, we establish a linear programming approach, and prove the existence of a stationary optimal control strategy out of a more general class of randomized strategies. This is done by making use of the tools from Markov decision processes.
Interactive Evolutionary Computation : Fusion of the Capabilities of EC Optimization and Human Evaluation † 高木英行 九州芸術工科大学芸術情報設計学科

In this paper, we survey the research on interactive evolutionary computation (IEC). The IEC is an EC that optimizes systems based on subjective human evaluation. The definition and features of the IEC are first described and then followed by an overview of the IEC research. The overview primarily consists of application research and interface research. In this survey, the IEC application fields include graphic arts and animation, 3-D CG lighting, music, editorial design, industrial design, facial image generation, speech processing and synthesis, hearing aid fitting, virtual reality, media database retrieval, data mining, image processing, control and robotics, food industry, geophysics, education, entertainment, social system, and so on. Also in this survey, the interface research to reduce human fatigue includes improving fitness input interfaces and displays based on fitness prediction, accelerating EC convergence especially in early EC generations, examining combinations of interactive and normal EC, and investigating active user intervention. Finally, we discuss the IEC from the point of the future research direction of computational intelligence. The biggest feature of this paper is to wholly survey them with about 250 IEC papers rather than to carefully select representative papers to show the status quo of the IEC researches.
Scaphoid Plate Osteosynthesis in Complex Fractures and Wrist Trauma: A Case Series

Introduction Treatment of scaphoid fracture is challenging due to its unique blood supply and geometry. Traditionally, a headless compression screw is the standard treatment for unstable scaphoid fracture. Some fractures are complex, for example, comminution with bone loss. A scaphoid plate is an option in these difficult fractures providing adequate rotational stability. Aim To share our experience in using scaphoid plates in complex wrist trauma and comminuted fractures. Method and material Complex wrist trauma involving scaphoid fractures that were comminuted and multi-fragmentary fractures treated with plate osteosynthesis were retrospectively reviewed between July 2019 and September 2021. Patient demographic data, preoperative radiographs, CT scans, pain, wrist range of motion, and fracture union rate to union were reviewed. Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH®) score was recorded at 1-year postoperative follow-up. Results Nine patients associated with complex wrist trauma were included in this case series. The mean follow-up was 2.5 years (13-30 months). The union rate was 100%. The mean arc of motion was 105° (95-110°). QuickDASH® score was 19.96 at 1-year postoperative follow-up. Four patients had good outcomes, four satisfactory, and one poor outcome. One hardware complication was observed which was the impingement of the plate proximally over the articular surface of the distal radius. Conclusion A scaphoid plate is a reliable option for treating complex and difficult fractures. It provides adequate stability, especially in comminution, bone loss, or multi-fragmentary fractures which are not amendable using other fixation methods. We recommend the expansion of plate osteosynthesis beyond scaphoid nonunion into complex wrist trauma.
DOUBLE COMPACT OBJECTS. III. GRAVITATIONAL-WAVE DETECTION RATES

The unprecedented range of second-generation gravitational-wave (GW) observatories calls for refining the predictions of potential sources and detection rates. The coalescence of double compact objects (DCOs)—i.e., neutron star–neutron star (NS–NS), black hole–neutron star (BH–NS), and black hole–black hole (BH–BH) binary systems—is the most promising source of GWs for these detectors. We compute detection rates of coalescing DCOs in second-generation GW detectors using the latest models for their cosmological evolution, and implementing inspiral-merger-ringdown gravitational waveform models in our signal-to-noise ratio calculations. We find that (1) the inclusion of the merger/ringdown portion of the signal does not significantly affect rates for NS–NS and BH–NS systems, but it boosts rates by a factor of ∼1.5 for BH–BH systems; (2) in almost all of our models BH–BH systems yield by far the largest rates, followed by NS–NS and BH–NS systems, respectively; and (3) a majority of the detectable BH–BH systems were formed in the early universe in low-metallicity environments. We make predictions for the distributions of detected binaries and discuss what the first GW detections will teach us about the astrophysics underlying binary formation and evolution.
A Novel mmWave Beam Alignment Approach for Beyond 5G Autonomous Vehicle Networks

Nowadays, directional communication represents a high potential solution for Vehicle-to-Everything (V2X) communication in Beyond-Fifth-Generation (B5G) vehicular networks, using the millimeter wave (mmWave) technique. Due to the high mobility in the vehicular environment and to ensure a higher data rate to establish a reliable V2X communication link, an efficient beam alignment is needed to point the optimal direction between the moving vehicle and the mmWave base station. To deal with this issue, we propose in this paper a new beam alignment method to select the optimal beam angle of Departure (AoD) from the mmWave base station, used further to transmit data toward the moving vehicle directly. The novelty of our proposal concerns the suggestion of an original hybrid beam alignment approach, combining a 128-filters-based Convolutional Neural Network (CNN) and 4-layers based Bidirectional Long Short-Term Memory (BiLSTM). The selected angle is performed automatically for each vehicle position with the lowest error probability and the highest received signal power. The performance of our proposed CNN-BiLSTM model was evaluated using popular regression metrics such as mean squared error (MSE), mean absolute error (MAE), and root-mean-square error (RMSE). The results show that our model achieved values of at least 0.0107, 0.0765, and 0.103 for MSE, MAE, and RMSE, respectively, outperforming other machine learning algorithms such as KNN regressor, SVR, BiLSTM, and CNN-LSTM.
The Monitor project: rotation of low-mass stars in the open cluster NGC 2547: Rotation of low-mass stars in NGC 2547

We report on the results of a V and i-band time-series photometric survey of M34 (NGC 1039) using the Wide Field Camera (WFC) on the Isaac Newton Telescope (INT), achieving better than 1% precision per data point for 13 ~ 5 days, consistent with the work of other authors (eg. Scholz & Eisloffel 2004) at very low masses. Our results are interpreted in the context of previous work, finding that we reproduce the same general features in the rotational period distributions. A number of rapid rotators were found with velocities ~ a factor of two lower than in the Pleiades, consistent with models of angular momentum evolution assuming solid body rotation without needing to invoke core-envelope decoupling.
Impetiginous Cutaneous Leishmaniasis after COVID-19 Infection in a Patient with Poor Cardiac Profile: A Case Report and Literature Review

Cutaneous leishmaniasis incidence has been rising in the past couple of decades. Standard therapy often includes antileishmanial drugs; however, due to their low safety and toxicity threshold, alternative treatments are being investigated. The association between COVID-19 and cutaneous leishmaniasis remains unclear and exploring this connection may offer crucial insights into the pathophysiology of and treatment strategies for infected patients. In this article, we describe a case of a male patient with a history of cardiac and other comorbidities who presented with cutaneous leishmaniasis in the form of impetigo-like skin lesions after being infected with COVID-19. Due to the patient’s poor cardiac profile, sodium stibogluconate was not used and an alternative therapeutic approach was employed. The patient was treated with oral terbinafine, cryotherapy on specific lesions, and a course of cephalexin. Following the course of treatment and subsequent follow-up, the patient exhibited complete resolution and healing of the lesions with scarring, and no active lesions or recurrence were observed. This case highlights the potential for alternative treatment strategies for cutaneous leishmaniasis in patients with comorbidities and emphasizes the importance of further research to better understand the link between COVID-19 and cutaneous leishmaniasis.
Dissecting Airborne Allergens

Asthma is a heterogeneous and very complex group of diseases, and includes different clinical phenotypes depending on symptoms, progression, exacerbation patterns, or responses to treatment, among other characteristics. The allergic phenotype is the most frequent, especially in pediatric asthma. It is characterized by sensitization (the production of specific IgEs) to allergens and frequent comorbidity with rhinitis as well as atopic dermatitis. Given the complexity of allergic asthma, knowledge of it must be approached from different points of view: clinical, histological, physiological, epidemiological, biochemical, and immunological, among others. Since partial approaches do not allow for the understanding of this complexity, it is necessary to have multidimensional knowledge that helps in performing the optimal management of each case, avoiding a “blind men and elephant parable” approach. Allergens are antigens that trigger the production of specific IgE antibodies in susceptible individuals, who present symptoms that will depend on the type and intensity of the allergenic load as well as the tissue where the interaction occurs. Airborne allergens cause their effects in the respiratory tract and eyes, and can be indoor or outdoor, perennial, or seasonal. Although allergens such as mites, pollens, or animal dander are generally considered single particles, it is important to note that they contain different molecules which could trigger distinct specific IgE molecules in different patients. General practitioners, pediatricians, and other physicians typically diagnose and treat asthma based on clinical and pulmonary function data in their daily practice. This nonsystematic and nonexhaustive revision aims to update other topics, especially those focused on airborne allergens, helping the diagnostic and therapeutic processes of allergic asthma and rhinitis.
GMP Synthetase: Allostery, Structure, and Function

Glutamine amidotransferases (GATs) catalyze the hydrolysis of glutamine and transfer the generated ammonia to diverse metabolites. The two catalytic activities, glutaminolysis and the subsequent amination of the acceptor substrate, happen in two distinct catalytic pockets connected by a channel that facilitates the movement of ammonia. The de novo pathway for the synthesis of guanosine monophosphate (GMP) from xanthosine monophosphate (XMP) is enabled by the GAT GMP synthetase (GMPS). In most available crystal structures of GATs, the ammonia channel is evident in their native state or upon ligand binding, providing molecular details of the conduit. In addition, conformational changes that enable the coordination of the two catalytic chemistries are also informed by the available structures. In contrast, despite the first structure of a GMPS being published in 1996, the understanding of catalysis in the acceptor domain and inter-domain crosstalk became possible only after the structure of a glutamine-bound mutant of Plasmodium falciparum GMPS was determined. In this review, we present the current status of our understanding of the molecular basis of catalysis in GMPS, becoming the first comprehensive assessment of the biochemical function of this intriguing enzyme.