Miracle-dz/UniFAR-FTUs huggingface dataset:
Oxidation Resistant, Cr Retaining, Electrically Conductive Coatings on Metallic Alloys for SOFC Interconnects

This report describes significant results from an on-going, collaborative effort to enable the use of inexpensive metallic alloys as interconnects in planar solid oxide fuel cells (SOFCs) through the use of advanced coating technologies. Arcomac Surface Engineering, LLC, under the leadership of Dr. Vladimir Gorokhovsky, is investigating filtered-arc and filtered-arc plasma-assisted hybrid coating deposition technologies to promote oxidation resistance, eliminate Cr volatility, and stabilize the electrical conductivity of both standard and specialty steel alloys of interest for SOFC metallic interconnect (IC) applications. Arcomac has successfully developed technologies and processes to deposit coatings with excellent adhesion, which have demonstrated a substantial increase in high temperature oxidation resistance, stabilization of low Area Specific Resistance values and significantly decrease Cr volatility. An extensive matrix of deposition processes, coating compositions and architectures was evaluated. Technical performance of coated and uncoated sample coupons during exposures to SOFC interconnect-relevant conditions is discussed, and promising future directions are considered. Cost analyses have been prepared based on assessment of plasma processing parameters, which demonstrate the feasibility of the proposed surface engineering process for SOFC metallic IC applications.
Nep1-like proteins from three kingdoms of life act as a microbe-associated molecular pattern in Arabidopsis

Significance Peptide fragments of Nep1-like proteins (NLPs), occurring in diverse microorganisms of three different kingdoms of life, were found to trigger immunity in the model plant Arabidopsis, indicating that they act as a microbe-associated molecular pattern (MAMP). A synthetic peptide of 24 aa from the central part of the downy mildew HaNLP3 protein was found to activate the plant immune system and trigger resistance to this pathogen. Strikingly, not only peptides of oomycete NLPs, but also those of bacteria and fungi were shown to act as a MAMP. This unprecedented broad taxonomic distribution demonstrates that the occurrence of a MAMP is not necessarily restricted to a class of microorganisms but can occur in a wide range of species from the tree of life. Necrosis and ethylene-inducing peptide 1 (Nep1)-like proteins (NLPs) are secreted by a wide range of plant-associated microorganisms. They are best known for their cytotoxicity in dicot plants that leads to the induction of rapid tissue necrosis and plant immune responses. The biotrophic downy mildew pathogen Hyaloperonospora arabidopsidis encodes 10 different noncytotoxic NLPs (HaNLPs) that do not cause necrosis. We discovered that these noncytotoxic NLPs, however, act as potent activators of the plant immune system in Arabidopsis thaliana. Ectopic expression of HaNLP3 in Arabidopsis triggered resistance to H. arabidopsidis, activated the expression of a large set of defense-related genes, and caused a reduction of plant growth that is typically associated with strongly enhanced immunity. N- and C-terminal deletions of HaNLP3, as well as amino acid substitutions, pinpointed to a small central region of the protein that is required to trigger immunity, indicating the protein acts as a microbe-associated molecular pattern (MAMP). This was confirmed in experiments with a synthetic peptide of 24 aa, derived from the central part of HaNLP3 and corresponding to a conserved region in type 1 NLPs that induces ethylene production, a well-known MAMP response. Strikingly, corresponding 24-aa peptides of fungal and bacterial type 1 NLPs were also able to trigger immunity in Arabidopsis. The widespread phylogenetic distribution of type 1 NLPs makes this protein family (to our knowledge) the first proteinaceous MAMP identified in three different kingdoms of life.
Elasto-mammography: Theory, Algorithm, and Phantom Study

A new imaging modality framework, called elasto-mammography, is proposed to generate the elastograms of breast tissues based on conventional X-ray mammography. The displacement information is extracted from mammography projections before and after breast compression. Incorporating the displacement measurement, an elastography reconstruction algorithm is specifically developed to estimate the elastic moduli of heterogeneous breast tissues. Case studies with numerical breast phantoms are conducted to demonstrate the capability of the proposed elasto-mammography. Effects of noise with measurement, geometric mismatch, and elastic contrast ratio are evaluated in the numerical simulations. It is shown that the proposed methodology is stable and robust for characterization of the elastic moduli of breast tissues from the projective displacement measurement.
Analysis of the disruption in hypothalamic-pituitary regulation in rats treated neonatally with monosodium L-glutamate (MSG): evidence for the involvement of tuberoinfundibular cholinergic and dopaminergic systems in neuroendocrine regulation.

Adult rats which have received monosodium-L-glutamate (MSG) (4 mg/g body weight) on alternate days for the first ten days of life acquire neurotoxic lesions of the retina and arcuate nucleus and manifest an endocrine deficiency syndrome characterized by stunted growth, obesity, hypothyroidism, hypogonadism and pituitary atrophy. In the present study, the biochemical basis for the MSG-induced endocrine dysfunction has been examined and the findings of note are as follows: normal serum levels of TSH and LH despite hypothyroidism and gonadal atrophy, and significantly reduced serum GH levels in both males and females; elevated serum PRL levels in males, but not females; normal or augmented pituitary release of LH and TSH to exogenous LHRH and TRH. Within the central nervous system: a normal diurnal rhythm of pineal N-acetyltransferase activity despite optic atrophy; normal concentrations of LHRH, TRH and somatostatin within the medial basal hypothalamus; normal concentrations of norepinephrine (NE), choline .
Determination of the optical properties of anisotropic biological media using isotropic and anisotropic diffusion models

The anisotropic light propagation in biological tissue is investigated in the steady-state and time domains. Monte Carlo simulations performed for tissue that has anisotropic optical properties show that the steady-state and time-resolved reflectance depends strongly on the measurement direction. We examined the determination of the optical properties using an isotropic diffusion model and found that in the time domain, in contrast to steady-state spatially-resolved reflectance measurements, the obtained absorption coefficient does not depend on the measurement direction and is close to the correct value. We performed measurements of the steady-state and time-resolved reflectance from porcine and bovine tendon which confirmed the theoretical findings. In addition, we compared the results obtained from Monte Carlo simulations with the solutions of the anisotropic diffusion theory for reflectance from semi-infinite media and for transmittance from slabs. In contrast to the literature, we found that the anisotropic diffusion equation is, in general, not a valid approximation to the anisotropic light propagation even in the diffusive regime.
Quantitative imaging of tumour blood flow by contrast-enhanced magnetic resonance imaging

Tumour blood flow plays a key role in tumour growth, formation of metastasis, and detection and treatment of malignant tumours. Recent investigations provided increasing evidence that quantitative analysis of tumour blood flow is an indispensable prerequisite for developing novel treatment strategies and individualizing cancer therapy. Currently, however, methods for noninvasive, quantitative and high spatial resolution imaging of tumour blood flow are rare. We apply here a novel approach combining a recently established ultrafast MRI technique, that is T1-relaxation time mapping, with a tracer kinetic model. For validation of this approach, we compared the results obtained in vivo with data provided by iodoantipyrine autoradiography as a reference technique for the measurement of tumour blood flow at a high resolution in an experimental tumour model. The MRI protocol allowed quantitative mapping of tumour blood flow at spatial resolution of 250 × 250 μm2. Correlation of data from the MRI method with the iodantipyrine autoradiography revealed Spearman's correlation coefficients of Rs = 0.851 (r = 0.775, P < 0.0001) and Rs = 0.821 (r = 0.72, P = 0.014) for local and global tumour blood flow, respectively. The presented approach enables noninvasive, repeated and quantitative assessment of microvascular perfusion at high spatial resolution encompassing the entire tumour. Knowledge about the specific vascular microenvironment of tumours will form the basis for selective antivascular cancer treatment in the future. © 2001 Cancer Research Campaign http://www.bjcancer. com
Targeting of insect epicuticular lipids by the entomopathogenic fungus Beauveria bassiana: hydrocarbon oxidation within the context of a host-pathogen interaction

Broad host range entomopathogenic fungi such as Beauveria bassiana attack insect hosts via attachment to cuticular substrata and the production of enzymes for the degradation and penetration of insect cuticle. The outermost epicuticular layer consists of a complex mixture of non-polar lipids including hydrocarbons, fatty acids, and wax esters. Long chain hydrocarbons are major components of the outer waxy layer of diverse insect species, where they serve to protect against desiccation and microbial parasites, and as recognition molecules or as a platform for semiochemicals. Insect pathogenic fungi have evolved mechanisms for overcoming this barrier, likely with sets of lipid degrading enzymes with overlapping substrate specificities. Alkanes and fatty acids are substrates for a specific subset of fungal cytochrome P450 monooxygenases involved in insect hydrocarbon degradation. These enzymes activate alkanes by terminal oxidation to alcohols, which are further oxidized by alcohol and aldehyde dehydrogenases, whose products can enter β-oxidation pathways. B. bassiana contains at least 83 genes coding for cytochrome P450s (CYP), a subset of which are involved in hydrocarbon oxidation, and several of which represent new CYP subfamilies/families. Expression data indicated differential induction by alkanes and insect lipids and four CYP proteins have been partially characterized after heterologous expression in yeast. Gene knockouts revealed a phenotype for only one (cyp52X1) out of six genes examined to date. CYP52X1 oxidizes long chain fatty acids and participates in the degradation of specific epicuticular lipid components needed for breaching the insect waxy layer. Examining the hydrocarbon oxidizing CYP repertoire of pathogens involved in insect epicuticle degradation can lead to the characterization of enzymes with novel substrate specificities. Pathogen targeting may also represent an important co-evolutionary process regarding insect cuticular hydrocarbon synthesis.
specificity of spliceosomal protein hPrp 31 Structural basis for the dual U 4 and U 4 atac snRNA-binding Material Supplemental

Human proteins 15.5K and hPrp31 are components of the major spliceosomal U4 snRNP and of the minor spliceosomal U4atac snRNP. The two proteins bind to related 59-stem loops (59SLs) of the U4 and U4atac snRNAs in a strictly sequential fashion. The primary binding 15.5K protein binds at K-turns that exhibit identical sequences in the two snRNAs. However, RNA sequences contacted by the secondary binding hPrp31 differ in U4 and U4atac snRNAs, and the mechanism by which hPrp31 achieves its dual specificity is presently unknown. We show by crystal structure analysis that the capping pentaloops of the U4 and U4atac 59SLs adopt different structures in the ternary hPrp31–15.5K–snRNA complexes. In U4atac snRNA, a noncanonical base pair forms across the pentaloop, based on which the RNA establishes more intimate interactions with hPrp31 compared with U4 snRNA. Stacking of hPrp31–His270 on the noncanonical base pair at the base of the U4atac pentaloop recapitulates intramolecular stabilizing principles known from the UUCG and GNRA families of RNA tetraloops. Rational mutagenesis corroborated the importance of the noncanonical base pair and the U4atac-specific hPrp31–RNA interactions for complex stability. The more extensive hPrp31–U4atac snRNA interactions are in line with a higher stability of the U4atac compared with the U4-based ternary complex seen in gel-shift assays, which may explain how U4atac snRNA can compete with the more abundant U4 snRNA for the same protein partners in vivo.
A Recommendation Framework towards Personalized Services in Intelligent Museum

Museum visitors are being overloaded with increasing amount and variety of information that heavens their burden to locate what is really interesting. Development of personalized service for museum visitors makes a promising effort to alleviate the problem. In this paper, a recommendation framework and the related algorithms are proposed for intelligent museum. Using both the explicit and implicit visit behaviors data, preference learning algorithm computes the preference of a visitor in exhibits. Exhibit recommendation algorithm takes a visitor’s preference and the public evaluation history on exhibits into account in the pre-selection and refinement of recommended exhibits. We implemented the recommendation framework based on our previously developed smart museum platform, iMuseum. The effectiveness of the proposed framework and algorithms are verified through experiments.
A Random Spatial lbest PSO-Based Hybrid Strategy for Designing Adaptive Fuzzy Controllers for a Class of Nonlinear Systems

In this paper, a new variant of particle swarm optimization (PSO), called random spatial lbest PSO model, is proposed and implemented for designing a newly devised stable adaptive hybrid fuzzy controller. The newly developed concurrent hybrid strategy for designing fuzzy controllers utilizes the conventional Lyapunov theory and the proposed PSO-based stochastic approach. The objective is to design a self-adaptive fuzzy controller online, optimizing both its structures and free parameters such that the designed controller can guarantee the desired stability and simultaneously provide satisfactory transients performance. The global version and two different lbest variants of PSO schemes and the proposed random spatial lbest model of PSO are employed for three popular, challenging, and nonlinear processes, and the proposed controller emerges as the superior algorithm in terms of tracking performance overall. These results aptly demonstrate the usefulness of the proposed approach.
WenZher: comprehensive vertical search for healthcare domain

Online health seeking has transformed the way of health knowledge exchange and reusability. The existing general and vertical health search engines, however, just routinely return lists of matched documents or question answer (QA) pairs, which may overwhelm the seekers or not sufficiently meet the seekers' expectations. Instead, our multilingual system is able to return one multi-faceted answer that is well-structured and precisely extracted from multiple heterogeneous healthcare sources. Further, should the seekers not be satisfied with the returned search results, our system can automatically route the unsolved questions to the professionals with relevant expertise.
COPAL: An adaptive approach to context provisioning

Context-aware services need to acquire context information from heterogeneous context sources. The diversity of service requirements posts challenges on context provisioning systems as well as their programming models. This paper proposes COPAL (COntext Provisioning for ALl) — an adaptive approach to context provisioning. COPAL is at first a runtime middleware, which provides loose-coupling between context and its processing. The component architecture of COPAL ensures that new context processing functions can be added dynamically. A set of context processing patterns are proposed to customize context attributes and compose context provisioning schemes. The COPAL components and models are reflected in a Domain Specific Language (DSL), which can further reduce the development efforts of context provisioning using automatic code generation. A motivating scenario is used throughout the paper to illustrate COPAL approach.
Low-rank Multi-view Clustering in Third-Order Tensor Space

The plenty information from multiple views data as well as the complementary information among different views are usually beneficial to various tasks, e.g., clustering, classification, de-noising. Multi-view subspace clustering is based on the fact that the multi-view data are generated from a latent subspace. To recover the underlying subspace structure, the success of the sparse and/or low-rank subspace clustering has been witnessed recently. Despite some state-of-the-art subspace clustering approaches can numerically handle multi-view data, by simultaneously exploring all possible pairwise correlation within views, the high order statistics is often disregarded which can only be captured by simultaneously utilizing all views. As a consequence, the clustering performance for multi-view data is compromised. To address this issue, in this paper, a novel multi-view clustering method is proposed by using \textit{t-product} in third-order tensor space. Based on the circular convolution operation, multi-view data can be effectively represented by a \textit{t-linear} combination with sparse and low-rank penalty using "self-expressiveness". Our extensive experimental results on facial, object, digits image and text data demonstrate that the proposed method outperforms the state-of-the-art methods in terms of many criteria.
Ontology Learning and Population in SmartWeb

The work described in this paper is concerned with the population and extension of a soccer ontology in the context of the SmartWeb2 project. The SmartWeb system is a multi-modal dialog system that derives answers from unstructured resources such as the web, from automatically acquired knowledge bases and from semantic web services. The system is thus able to provide intelligent information services that are accessible via mobile broadband devices. The main scenario for SmartWeb is the FIFA World Cup 2006. Here we describe SOBA and ISOLDE, two sub-components of the SmartWeb system.
Idarubicin, cytarabine, and pravastatin as induction therapy for untreated acute myeloid leukemia and high‐risk myelodysplastic syndrome

Previous studies suggest that idarubicin/cytarabine(ara‐C)/pravastatin (IAP) is an active salvage regimen for patients with AML. We therefore investigated this regimen in patients with newly‐diagnosed AML or MDS (≥10% blasts). Patients were eligible if the anticipated treatment‐related mortality (TRM) was <10%. Patients received pravastatin (1,280 mg/day po; days 1–8), cytarabine (1.5 g/m2/day; days 4–7), and idarubicin (12 mg/m2/day, days 4–6). Up to 3 cycles of consolidation with a shortened course was permitted. The primary endpoints were “good CR” rate (CR on day 35 without minimal residual disease) and TRM in the first 28 days. The study was to stop if after each cohort of 5 patients (a) the Bayesian posterior probability was < 5% that the true “good CR rate” was ≥ 70% or (b) the posterior probability was >25% that the TRM rate was ≥5%. Twenty‐four patients were included. Conventional CR was achieved in 15 (63%) patients but only 12 (50%) achieved “good CR”. 4 of 12 (33%) patients with “good CR” relapsed at median of 16 weeks (10.5–19). Five (21%) patients had refractory disease. Survival probability at 1 year was 72% (48.7–64). Two (8.3%) patients died within 28 days from multiorgan failure. The most common grade 3–4 adverse effects were febrile neutropenia (75%) and diarrhea (25%). Based on the stopping rules accrual ceased after entry of these 24 patients. IAP did not meet the predefined efficacy criteria for success. Therefore, we would not recommend this regimen for phase three testing in this patient subset. Am. J. Hematol. 90:483–486, 2015. © 2015 Wiley Periodicals, Inc.
End-to-End Network Delay-Constrained for QoS Multicast Routing

Multicast services are used in emerging multimedia applications based on Quality of Service (QoS) development of multimedia group application and the construction of multicast routing tree is significant. Upper bound on the delay between sender and receiver is one of the common QoS constraints. Delay-constrained routing protocols are used to find paths subject to the delay constraint while efficiently using network resources, also the delay constrained routing problem is difficult because, different constraints can conflict with another. Many of the delay-constrained routing protocols that have been proposed in the literature give priority to cost minimization during the path computing process. With this approach, we propose a new approach for end-to-end delay-constrained routing in a network, which captures the trade-off between cost minimization and the risk level regarding to the delay constraint. We propose a method called Delay-Constrained Routing Agent (DCRA) that implements our approach using a simple and efficient parameterized selection function.
A novel somatostatin‐immunoreactive mossy fiber pathway asssociated with HSP25‐immunoreactive purkinje cell stripes in the mouse cerebellum

Somatostatin 28 immunoreactivity (Sst28‐ir) identifies a specific subset of mossy fiber terminals in the adult mouse cerebellum. By using double‐labeling immunohistochemistry, we determined that Sst28‐ir is associated with presynaptic mossy fiber terminal rosettes, and not Purkinje cells, Golgi cells, or unipolar brush cells. Sst28‐ir mossy fibers are restricted to the central zone (lobules VI/VII) and nodular zone (lobules IX, X) of the vermis, and the paraflocculus and flocculus. Within each transverse zone the mossy fiber terminal fields form a reproducible array of parasagittal stripes. The boundaries of Sst28‐ir stripes align with a specific array of Purkinje cell stripes revealed by using immunocytochemistry for the small heat shock protein HSP25. In the cerebellum of the homozygous weaver mouse, in which a subpopulation of HSP25‐ir Purkinje cells are located ectopically, the corresponding Sst28‐ir mossy fiber projection is also ectopic, suggesting a role for a specific Purkinje cell subset in afferent pattern formation. Likewise, in the scrambler mutant mouse, Sst28‐ir mossy fibers show a very close association with HSP25‐ir Purkinje cell clusters. HSP25 itself does not appear to be critical for normal patterning, however: in the KJR mouse, which does not express cerebellar HSP25, Sst28 expression appears to be normal. Likewise, the Purkinje cell patterning antigens zebrin II and HSP25 are expressed normally in both Sst‐ and Sst‐receptor knockout mice, suggesting that somatostatinergic transmission is not necessary for Purkinje cell stripe formation. J. Comp. Neurol. 517:524–538, 2009. © 2009 Wiley‐Liss, Inc.