Miracle-dz/UniFAR-FTUs huggingface dataset:
TECTONOSTRATIGRAPHY OF THE BAIE VERTE OCEANIC TRACT AND ITS OPHIOLITE COVER SEQUENCE ON THE BAIE VERTE PENINSULA

The Baie Verte Peninsula is a centre for mining in insular Newfoundland, and comprises Early Ordovician ophiolite volcanic sequences that contain volcanogenic massive sulphide ± gold deposits, and several types of epigenetic gold mineralization. The excellent preservation and relatively simple structural history of the 489 Ma Betts Cove Complex and its cover sequence, the Snooks Arm Group, makes it an ideal template to test stratigraphic correlations across the Baie Verte Peninsula. Each major ophiolite sequence on the Baie Verte Peninsula can be correlated with the Betts Cove Complex. Correlative units include, boninites, 487 Ma felsic volcanic rocks (Rambler rhyolite) and overlying island-arc tholeiitic basalts of the lower Pacquet Harbour Group; the layered cumulates, gabbro, 489 Ma trondhjemite dykes, sheeted dykes, boninite and island-arc tholeiitic basalts of the Point Rousse Complex; and layered similar rocks of the Advocate Complex and lower Flatwater Pond Group. Distinctive marker units recognized in the ophiolite cover rocks of the Snooks Arm Group (basal conglomerate, iron formation, tholeiitic basalts, 470 Ma clinopyroxene-phyric calc-alkaline tuffs, and 467 Ma rhyolite) can all be found, in the same sequence, in equivalent cover rocks of the upper Pacquet Harbour Group, the Point Rousse cover sequence, and the Flatwater Pond Group. Thicker sequences of coarse-grained conglomerates in the Flatwater Pond and Shark Point groups are interpreted to reflect proximity to an ophiolitic basement that was thrust higher up the continental margin, relative to the thin units of finer grained conglomerate and thick iron formation that characterize the distal facies of the Snooks Arm Group. The recognition of correlations and marker units across the Baie Verte Peninsula suggests that existing stratigraphic nomenclature now merits revision and simplification.
Perfil socioepidemiológico e clínico de idosos afetados por hanseníase: contribuições para a enfermagem Social-epidemiologic and clinical profile of elderly people affected by leprosy: contributions to nursing

Objetivo: Tracar o perfil socioepidemiologico e clinico de idosos afetados por hanseniase. Metodos: Estudo descritivo, de abordagem quantitativa, com uma amostra de 60 idosos afetados por hanseniase, em dois Centros de Reabilitacao em Sao Luis - MA. Foi utilizado um questionario semiestruturado, contendo dados de identificacao, aspectos socioepidemiologicos e clinicos, analisados pelo programa EpiInfo versao 7. Resultados: Dentre os idosos, a maioria tinha entre 60 a 69 anos (53,3%), sexo masculino (58,3%), cor parda (66,6%), casado (45%) e com ate 6 (seis) contatos intradomiciliares (76,6%). Em relacao a classificacao operacional, 95% eram Multibacilares, com predominância para a forma Dimorfa (60%) e Wirchowiana (25,5%), a maioria em grau 1 de incapacidade (45%) e fazendo uso de Poliquimioterapia/Multibacilar/12 doses (93%). Conclusao: Essas informacoes podem contribuir para diferentes aspectos gerenciais e assistenciais, bem como possibilitam a prestacao do cuidado integral, conforme preconiza os principios e diretrizes do Sistema Unico de Saude. Descritores: Idoso, Hanseniase, Perfil de saude, Enfermagem.
From creativity to future: the role of career adaptability

The present study aimed to explore the effect of positive and negative creativity on the career construction process during adolescence. Since creativity has been conceptualized as a useful resource for identity construction, we tested the influence of creativity on future orientation, assessing the role of career adaptability. 338 high school students participated to the study. Structural equation model showed gender differences since hypothesized relations were only found significant in females. Results highlight a different function of positive creativity in Italian boys and girls. The use of creativity in career counseling for adolescents, through technological tools, is discussed.
Expectations Versus Reality: What Matters to Students of Economics vs. What They Receive from Universities?

The phenomenon of increasing tuition fees is one of the factors which reinforce the increasingly consumerist attitudes among students towards the product (understood as a whole process of university education) they receive from universities. The aim of the study is to characterise the difference between the expectations of students and the extent to which those expectations are met by universities. This analysis also focuses on the conditions that determine this perception of what universities offer and discusses selected issues concerning the relations between universities and industry. The findings demonstrate why creativity, apart from practical knowledge, is one of the most important aspects in the process of education, where a student’s graduation work is aimed at solving specific problems in companies and institutions. In the empirical part of the paper, students’ opinions about the importance of selected aspects of the education process are compared with the level of support provided by universities. The research covered 505 students of economics from 10 different countries. Their expectations of the educational process with regard to the majority of its aspects (apart from theoretical knowledge) proved to be higher than those of their universities. The findings of this research may thus be useful in formulating optimal study plans.
Pregabalin and placebo responders show different effects on central pain processing in chronic pancreatitis patients

Background Pain control in chronic pancreatitis is a major challenge; the mechanisms behind analgesic treatment are poorly understood. This study aims to investigate the differences in pain sensitivity and modulation in chronic pancreatitis patients, based on their clinical response (responders vs nonresponders) to placebo or pregabalin treatment. Methods This study was part of a randomized, double-blind, placebo-controlled trial evaluating the analgesic effects of pregabalin and placebo in chronic pancreatitis. Post hoc, patients were assigned to one of four groups, ie, responders and nonresponders to pregabalin (n=16; n=15) or placebo (n=12; n=17) treatment. Responders were defined as patients with >30% pain reduction after 3 weeks of treatment. We measured change in pain sensitivity before and after the treatment using electric pain detection thresholds (ePDT) in dermatomes C5 (generalized effects) and Ventral T10 (segmental effects). Descending endogenous pain modulation was quantified via conditioned pain modulation (CPM) paradigm. Results Sixty patients were analyzed in a per-protocol analysis. ePDT change in C5 was significant vs baseline and greater in pregabalin (1.3 mA) vs placebo responders (−0.1 mA; P=0.015). This was not so for ePDT in Ventral T10. CPM increased more in pregabalin (9%) vs placebo responders (−17%; P<0.001). CPM changed significantly vs baseline only for pregabalin responders (P=0.006). Conclusion This hypothesis-generating study provides the first evidence that pain relief with pregabalin is associated with anti-hyperalgesic effects and increased endogenous inhibitory modulation. No such effects were observed in patients experiencing pain relief with the placebo treatment. The mechanisms underlying analgesic response to placebo vs drug treatments are different and, together with their interactions, deserve further study.
Total Hip Arthroplasty and Surgical Wound Closure: Sutures Versus Staples

Discrepancies exist between studies that compare sutures and staples. We retrospectively reviewed 142 consecutive cases of total hip arthroplasty that had surgical wound re-approximation by either staples or absorbable subcuticular sutures. To our knowledge, this is the largest analysis of its kind in the literature. There were equal numbers of cases of sutures and staples (n=71). Two (2.8%) patients in the staple group developed an infection (one superficial and one organ/space) and 1 (1.4%) patient in the suture group developed a superficial infection. The mean total surgical time for the suture group was 119.6 minutes (sd=39.0) and 115.3 minutes (sd=24.2) for the staple group. No significant association was found between closure type and complications or surgical time (p>0.05 for all).
A Randomized Trial of Acyclovir for 7 Days or 21 Days with and without Prednisolone for Treatment of Acute Herpes Zoster

Background Acyclovir given for 7 to 10 days is of proved benefit in acute herpes zoster, but studies of its effectiveness in preventing postherpetic neuralgia have had conflicting results. The role of corticosteroids in the treatment of herpes zoster is also controversial. Methods We conducted a double-blind, controlled trial in patients with acute herpes zoster to determine whether either 21 days of acyclovir therapy or the addition of prednisolone offered any improvement over 7 days of acyclovir therapy. Patients with a rash of less than 72 hours' duration were assigned to receive acyclovir (800 mg orally, five times daily) for 7 days with either prednisolone or placebo, or acyclovir for 21 days with either prednisolone or placebo. Prednisolone therapy was initiated at a dose of 40 mg per day and tapered over a three-week period. Patients were assessed frequently through day 28 and then monthly through month 6 to assess postherpetic neuralgia. Results Of 400 patients recruited, 349 completed the study.
Functional Analysis of Hypoxia-inducible Factor-1α-mediated Transactivation

The hypoxia-inducible factor-1α (HIF-1α) is a key regulator of adaptive responses to hypoxia. HIF-1α has two independent transactivation domains (TADs). Whereas the N-terminal TAD (N-TAD) also constitutes a degradation box, the C-terminal TAD (C-TAD) functions in a strictly hypoxia-inducible fashion. Oxygen-dependent hydroxylation of an asparagine residue has recently been reported to regulate C-TAD function by disrupting the interaction with the CH1 domain of the p300/CBP coactivator at normoxia. Here we have performed alanine-scanning mutagenesis of a predicted α-helix within the C-TAD of mouse HIF-1α to identify residues important for transactivation and interaction of the C-TAD with transcriptional coactivators. We observed that several hydrophobic residues, Ile802, Leu808, Leu814, Leu815, and Leu818, were critical for transactivation and binding to the CH1 domain of CBP in hypoxic cells. Moreover, E812A/E813A and D819A mutations impaired hypoxia-dependent transactivation without disrupting binding to CH1. In the context of full-length HIF-1α, mutation of the leucine residues conferred conformational changes to the protein and significantly reduced the transactivation function as well as functional interaction with the transcriptional coactivators CBP and SRC-1. These mutations also affected intranuclear redistribution of HIF-1α in the presence of CBP, indicating that the integrity of the C-TAD is critical for intracellular localization of mouse HIF-1α.
ANALYSIS OF MEDICAL RECORD FILLING COMPLETENESS AND RETURNING IN HOSPITAL INPATIENT UNIT ANALISIS KELENGKAPAN PENGISIAN DAN PENGEMBALIAN REKAM MEDIS RAWAT INAP RUMAH SAKIT

Medical record is a compilation of documentation that consists of patient identity, evaluation, treatment, procedures and other health service in a health care centre. Resending procedures of medical records to Medical Records Unit at least 2x24 hours after outpatient process. It has to send back on time for many values. The aim of research was to analyze why the medical records were many medical records sent back lately to medical records unit in General Hospital of “X”. This was descriptive study with medical records as sample. They were medical records 195 files, taken by random sampling. The results showed that of the 195 files that timely repayment time as many as 57 files or 29%, while late as 138 files or 71%. Factors that led to the delay in returning the medical record were the completeness of medical record completeness, and the complete medical record filing, and compliance of health workers who responsible in filing the medical record. To minimize the incompletness of medical records, improve the ontime target. The medical staffs needs to expose by socialization of medical record.
Emergency Dermatology: CELL INJURY AND CELL DEATH

WHEN CELLS are damaged, as often occurs during trauma and metabolic stress, the organism has to choose whether to repair the damage by promoting cell survival or remove irreparably injured cells. Cell injury occurs when an adverse stimulus reversibly disrupts the normal, complex homeostatic balance of the cellular metabolism. In this case, after injury the cells attempt to seal breaks in their membranes, chaperone the removal or refolding of altered proteins, and repair damagedDNA.On the contrary, when cell injury is too extensive to permit reparative responses, the cell reaches a “point of no return” and the irreversible injury culminates in programmed cell death (PCD). Specific properties or features of cells make them more or less vulnerable to external stimuli, thus determining the kind of cellular response. In addition, the characteristic of the injury (type of injury, exposure time, or severity) will also affect the extent of the damage. We present a short overview of the best-known PCD pathways. We emphasize the apoptotic pathway, considered for years the hallmark of PCD, and the different stimuli that produce cell injury.
Pre-Processing of BOLD Signal and the Origin of Anticorrelations Pre-processing of BOLD data consists of three steps : first , averaging of BOLD signal across voxels within each of the 998

Pre-processing of BOLD data consists of three steps: first, averaging of BOLD signal across voxels within each of the 998 ROIs; second, linear detrending of the signal in consecutive 50-second time-windows for each ROI in turn; third, linear regression of mean global BOLD signal, mean ventricular BOLD signal and mean white matter BOLD signals from each ROI in turn. The residuals obtained from the linear regression are then entered into Pearson correlations for the calculation of rsFC.
A STUDY OF PRESCRIBING PATTERN OF NON STEROIDAL ANTI INFLAMMATORY DRUGS IN ORTHOPEDIC OUT PATIENT DEPARTMENT AT A TERTIARY CARE HOSPITAL

AIM: To determine the pattern of NON STEROIDAL ANTI INFLAMMATORY DRUGS prescribing for arthritic and non-arthritic conditions in orthopedic outpatient department. METHODOLOGY: 100 prescription duplicate collected and analyzed prospectively for the pattern of NSAID prescription for arthritic and non-arthritic conditions; the drug formulation, route, frequency, duration of admission and concomitant medications results. NSAID were prescribed for nontraumatic musculo skeletal 35% pain, 25% post traumatic pain, 20% osteoarthritis, 10% postoperative pain, 3% ankylosing spondylitis, 6% degenerative disease of spine, 1% neuralgia. The NSAIDs commonly prescribed were Aceclofenac 45%, Etodolac 20%, Diclofenac 24%, and Ibuprofen 11%. Fixed dose combination of NSAIDs with adjuvante was prescribed in. The adjuvants, included are paracetamol 55.6%, serratopeptidase 32.8%, chlorzoxazone 9.1%, Thiocolchichoside 2.5%. oral formulations of NSAIDs were prescribed in all patients, supplemented by Topical formulations as gel/cream in 15% of subjects. The dosing frequency was BID (65%), OD (25%), TID (2%), SOS (8%). Duration of administration ranged from 5-15 days.other classes of drugs used concomitantly were proton pump inhibitors, calcium supplements, Multivitamins, Anti microbials, Immuno suppressants, and Glucosamine. CONCLUSION: NSAIDs were prescribed empirically for various arthritic and Nonarthritic conditions, frequently as fixed dose combinations [FDC]s with various adjuvants as per the standard guide lines. However patient information was inadequate in most of the prescriptions. Proper patient Assessment deemed necessary for individualizing NSAIDs.
Theoretical Study on Spin-Selective Coherent Electron Transfer in a Quantum Dot Array

Recently, we proposed the spin-selective coherent electron transfer in a silicon-quantum-dot array. It requires temporal tuning of two pulses of an oscillating magnetic field and gate voltage control. This paper proposes a simpler method that requires a single pulse of oscillating magnetic field and gate voltage control. We examined the robustness of the control against the error in the pulse amplitude and the effect of the excited states relaxation to the control efficiency. In addition, we propose a novel control method based on a shortcuts-to-adiabaticity protocol, which utilizes two pulses but requires temporal control of the pulse amplitude for only one of them. We compared their efficiencies under the effect of realistic pulse amplitude errors and relaxation.
Exploration of the Microbial Biodiversity Associated with North Apulian Sourdoughs and the Effect of the Increasing Number of Inoculated Lactic Acid Bacteria Strains on the Biocontrol against Fungal Spoilage

In this study, we explored the diversity of yeasts and lactic acid bacteria (LAB) associated with six spontaneous sourdough fermentations from the northern part of the Apulian region (Italy). Bacterial and yeast isolates from sourdough were investigated by amplified ribosomal DNA restriction analysis (ARDRA) and restriction fragment length polymorphism (RFLP) analysis, respectively. The identification of the isolates was confirmed by sequencing bacterial 16S gene and yeast ITS1–5.8S–ITS2 rRNA gene amplicons. Microbiological analysis of all sourdough samples revealed that LAB and yeast counts ranged between 1.7 × 105 and 6.5 × 108 cfu/g, and 7.7 × 105 and 2.5 × 107 cfu/g, respectively. The molecular identification at species level revealed the occurrence of Lactobacillus plantarum as the dominant LAB and Saccharomyces cerevisiae as the dominant yeast species in all different sourdough samples. Then, the ability of all isolated strains to inhibit and/or reduce the growth of several selected fungi was valued through the overlay method. In light of their antifungal performances, ten LAB strains were inoculated, singularly and in combination, in subsequent bread-making trials. Overall, we confirmed the potential of LAB to extend the shelf life of bread through spoilage inhibition and, for the first time, we observed a synergistic effect due to the combination of several isolated LAB on the inhibition behavior against selected fungal spoilage strains. Our findings suggest the exploration of a LAB-based approach in order to extend the shelf life of bread, reducing, at the same time, the use of chemical agents for food preservation.
Effects of MDRl Gene C3435T polymorphism on bloold concentration and pharmacokinetics of telmisartan

AIM: To determine the effects of MDR1C3435T on the pharmacokinetics of telmisartan in healthy Chinese volunteers and blood concentration in hypertension patients.METHODS: The genotype on MDR1C3435T in 19 healthy Chinese volunteers who were received a single oral dose of 40 ng telmisartan and 61 hypertension patients who were received oral of 40 mg telmisartan every day after a month was detected by PCR RFLP method,the relationship of MDR1C3435T polymorphism and steady-state blood concentrations of telmisartan were determinated by HPLC-MS.The pharmacokinetics of telmisartan in health volunteers and steady-state telmisartan concentrations of patients with hypertension were compared among MDR1C3435T genotypes.RESULTS:Among the 61 cases of hypertension patients,the frequencies of C3435T CC,C3435T TT and C3435T CT were 39.34%,11.48% and 49.18%,respectively.There were no differences between normal people and hypertension patients in MDR1 ditribution.No significant difference in Cmax,tmax,t1/2,AUC0-48,AUC0-∞ and CL among MDR1 C3435T genotypes in health volunteers and no significant difference in steady-state concentration among MDR1C3435T genotypes in hypertension patients were observed.CONCLUSION: The MDR1 C3435T polymorphism does not affect the blood concentration and pharmacokinetics of telmisartan.
Economic constraints and stagnation in the Caribbean : some Theoretical explanations and a way forward

This paper develops a model of Caribbean growth and development along heterodox lines and addresses how the region responds to the challenge of sustainable development. Since the global economic crisis, Caribbean economies whether as goods or service producers have been limping along posting average growth of 1.8% in 2011, 0.4% in 2015 and less than 2.4% anticipated 2017(ECLAC, Preliminary Overview of the Caribbean) assuming robust growth among its major trading partners. At the same time, the region as a whole has had to confront a very high debt burden with debt to GDP ratio of 71% in 2015 on average. The tendency to debt accumulation is not new and while fiscal consolidation programmes have been pursued by several countries, either as home grown or IMF supported programmes, the debt burden remains stubbornly high. The traditional response has focused on raising taxes and curbing expenditure, despite sluggish domestic and global demand, in order to reduce government’s borrowing requirements and stabilise the budget deficits. The paper presents a carefully worked through model along neo‐Kaleckian lines aimed at determining the factors driving debt accumulation, stagnation and income distribution in the region. The model will also be tested using available data for two Caribbean countries within a structural VAR framework. Kalecki, M. (1954), Theory of Economic Dynamics, Unwin, London, reprinted New York, Monthly Review Press, 1968 Acknowledgement I would like to thank the office of human resources for affording me the opportunity to conduct four months of continuous research and the acting Director and Staff of the Sir Arthur Lewis Institute of Social and Economic Research (SALISES), Mona Jamaica , for their hospitality and the facilities afforded me to conduct this research. I also thank my colleagues Machel Pantin at ECLAC, Port of Spain and Samuel Indalmanie at the Statistical Institute of Jamaica(STATIN), for their valuable contributions in the development of this paper.
ELEARNING ENVIRONMENT AS A FACILITATOR FOR KNOWLEDGE CREATION USING SECI MODEL IN THE CONTEXT OF BA

Using eLearning technology today in education is changing the way in which knowledge is introduced, stored and distributed, accordingly; knowledge management technologies is used to rapidly capture, organize and deliver large amounts of new knowledge. BA as a shared context in eLearning environment requires students to share, construct and utilize knowledge through knowledge creation processes as proposed in Nonaka's model of knowledge creation (SECI). This research aims to introduce and prove that eLearning environments supports the knowledge processes and creates conditions which are consistent with Nonaka's model of knowledge creation (SECI) and the concept of BA as a shared context for knowledge creation processes and activities, a research model was built and hypotheses were formed to reflect it, then a survey was distributed between the students of Syrian Virtual University (SVU) to collect the primary data to discover the strength of relationships between the model variables, The results demonstrates that BA as a shared context affects positively knowledge creation model (SECI) in the mediation of eLearning environment. This research is a consolidated contribution to field of eLearning by engaging knowledge management concepts in the whole process of it.