Miracle-dz/UniFAR-FTUs huggingface dataset:
Resource Complementarity and Performance in Technology-Intensive Mergers and Acquisitions

This paper examines the influence of complementarity between technological resources and functional resources in ex-post performance of mergers and acquisitions. While prior work has looked at complementarity as an indication of fit within a particular resource domain, this study focused on the complementarity between different resource domains. We specifically tested the performance impact associated with complementarity between the technological resources of the one merger partner and the functional resources of the other merger partner, including financial, marketing and operational resources. Performance was measured in both marker-based (i.e., ex ante stock market returns at announcement) and operational terms (i.e., ex post increases in sales revenues of the combined firm). Our results indicate that complementarities between a target's technological resources and the acquirer's financial and marketing resources produce positive effects on post-merger sales growth and ex-ante stock market returns. Surprisingly, our results also revealed that complementarity between the target's technological resources and the acquirer's operational resources had a negative effect on posr merger sales growth. We discuss the implications of these findings for managers contemplating mergers and acquisitions.
Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulates Systemic Parameters Independently of Skeletal Muscle PGC- 1α.

Resveratrol (RSV) and SRT1720 (SRT) elicit beneficial metabolic effects and are postulated to ameliorate obesity and related metabolic complications. The co-activator, peroxisome proliferator- activated receptor γ co - activator 1α (PGC- 1α) has emerged as a major downstream effector responsible for metabolic remodeling of muscle and other metabolic tissues in response to RSV or SRT treatment. However, the requirement of PGC- 1α in skel etal muscle for the systemic metabolic effects of these compounds has so far not been demonstrated. Using muscle-specific PGC- 1α knockout mice, we show that PGC- 1α is necessary for transcriptional induction of mitochondrial genes in muscle with both RSV and SRT treatment. Surprisingly, the beneficial effects of SRT on glucose homeostasis and of both compounds on energy expenditure occur even in the absence of muscle PGC- 1α. Moreover, RSV and SRT treatment elicit differential transcriptional effects on genes involved in lipid metabolism and mitochondrial biogenesis in liver and adipose tissue. These findings indicate that RSV and SRT do not induce analogous metabolic effects in vivo . Our results provide important insights into the mechanism, effects and organ specificity of the caloric restriction mimetics RSV and SRT. These findings are important for the design of future therapeutic interventions aimed at ameliorating obesity and obesity-related metabolic dysfunction.
Application of diffusion tensor imaging in detecting microstructural alteration of the trigeminal nerve root in patients with classical trigeminal neuralgia without neurovascular compression

Background Diffusion tensor imaging (DTI) was used to detect microstructural alteration and influence of surgical intervention of the trigeminal nerve root (TR) in patients with classical trigeminal neuralgia (CTN) without neurovascular compression (woNVC) who had undergone internal neurolysis (IN). Methods Overall, 21 patients with CTN woNVC who underwent IN and 20 healthy controls were included prospectively. The differences in the means, kurtosis and skewness of each of the diffusivity metrics between the affected and unaffected nerves in patients and both nerves in controls, were then analyzed using the independent t test. Data from the affected side and the unaffected side before and 1 years after IN were compared. Results There were significantly different mean and kurtosis values for both FA and ADC of the affected side TR, compared to the unaffected side and control group respectively before IN. 1 year after surgery, most of these differences significantly reduced in comparison between the affected side and unaffected side, the affected side and control group, and these trends were also in accordance with the relief of pain. The Pearson correlation coefficient showed a strong negative correlation between decrease of ADC in the affected side compared to the surgical outcome in BNI total score. Conclusions The changes of diffusive property of TR could explain the efficiency of IN. The pretreatment DTI metrics could be an effective prognostic factor for providing potential noninvasive, brain-based biomarkers to support an optimal treatment selection for individual patients with CTN woNVC.
Extended great deluge approach for the integrated dynamic berth allocation and crane assignment problem

Globalization has quickly increased the volume of commodity flows using all modes of transport. Specifically, since the 1970s, containerization has increasingly facilitated the transport of goods throughout the world, and every major port is expected to double, and possibly triple, its container traffic by 2020. In order to accommodate the growth in international container transport, terminals must make significant changes to keep pace with increasing demand. One important manner in which existing terminal capacity could be increased would be through an increase in their efficiency. In this paper, we consider terminal efficiency from the perspective of simultaneously improving both berth and quay crane scheduling. The approach is applied to a modeling scheme found in the literature, and this study contributes to knowledge by improving the results found using a new metaheuristic and a crane transfer refinement procedure.
Comparison of teachers’ and vocalists’ awareness of voice functioning, voice emission therapy and physiotherapy

Significant differences in awareness of voice functioning between teachers and vocalists were noticed. It can be stated that among teachers the deteriorating voice correlates with the increase in age. On the other hand, among vocalists, the level of perceived voice fatigue remains relatively constant while aging. Teachers who participated in the study show significantly less awareness of the principles of proper voice emission and hygiene than vocalists, as demonstrated by the Voice Handicap Index.
Genomic selection and its significance in Indian dairying

© A bstract: Genomic selection is now a reality particularly in dairy cattle. The strategy for genomic selection is based on whole genome SNP marker effects. The method was first used in the year 2008 in cattle and since then frequent improvements have been proposed. Genomic selection strategy is still an emerging field and is a naïve science in India. In near future with the improvement in the field of data analysis, it is expected to soon transform the existing methodologies used in genomic selection. The present article is an attempt to review the concepts of genomic selection in dairy animals, current methods used for genomic evaluations and their accuracy, and discusses the relevance and practical limitation in implementation of genomic selection under Indian dairying
CMAR_A_350038 1075..1085

Natalia Valdiviezo, Cindy Alcarraz , Denisse Castro , Renzo Salas, Victor Begazo-Mollo, Marco Galvez-Villanueva, Luz Medina Aguirre, Elica Garcia-León , Isela Quispe-Santivañez, Carmen Cornejo-Raymundo , Eduardo Paz-Cornejo, Luis Sanchez-Vilela , Vanessa BermudezAlfaro, Juan Carlos Vargas-Nina, Carlos Pérez-Ramos, Andrea Meza-Hoces, Paolo R Valdez Barreto, Ruth Huaringa-Leiva, Johanny Muro-Cieza, Valeria Aguilar-Vásquez, Eduardo Yache Cuenca, Silvia NeciosupDelgado, Nathaly Poma-Nieto, Sheyla Chavez-Gavino, Lenin Fernandez-Rosas, Jhajaira M Araujo , Eduardo Payet, Henry L Gomez
Cash in Hand, Want Better Looking Mate: Significant Resource Cues Raise Reported Mating Standards in Men

Resources are a cardinal component of male mate value in the sexual exchange between men and women. Inspired by theories and research suggesting a link between mating and resource constructs as well as studies linking money and valuations of others, the current study tests the hypothesis that cues to resource availability may lead to higher mating standards for men, but not women. Participants were exposed to either stacks of paper, a small sum of money (104 Singapore dollars ∼USD$84), or a large sum of money (2600 Singapore dollars ∼USD$2100). Consistent with the hypothesis, after male – but not female – participants handled a large sum of money, they raised their minimum requirements for a date. We discuss how the results are consistent with an evolutionary perspective on mating and how future research can further investigate environmentally contingent self-assessments and strategies.
PROFITABILITY AND TECHNICAL EFFICIENCY IN IRRIGATED ONION PRODUCTION UNDER MIDDLE RIMA VALLEY IRRIGATION PROJECT IN GORONYO, SOKOTO STATE NIGERIA

The study analyzed profitability and technical efficiency in irrigated onion production under Middle Rima valley irrigation project in Goronyo, Sokoto State Nigeria. The primary data used for the study were obtained using structured questionnaire administered to 90 randomly selected farmers. Descriptive statistics, gross margin, net farm income, gross ratio, operation ratio, return on investment and stochastic frontier production function were used to analyze the data. The result showed that estimated gross margin; net farm income; gross ratio; operating ratio; and return on capital investment gives an estimated values of N367,332.73 per hectare, N347,792.54 per hectare, 0.25,0.21 and 3.58 respectively. The mean efficiency obtained was 94.67 percent indicating that there was a 5.33 percent allowance for improving efficiency. The result also showed that, farmers’ educational level, years of farming experience and access to extension service significantly influenced the farmers’ efficiency positively. It is recommended that relevant policies that would enhance the technical skill of the farmers and access to to extension services should be evolved by the stakeholders.
Time and Temporality in HCI Research

‘Time’ and ‘temporality’ are increasingly addressed in human-computer interaction (HCI) research. From issues related to mapping and visualizing data along timelines via explorations of temporality as a design material to studies of lag and the rhythms of work, time is a recurring perspective in HCI research. In fact, time has been a recurring aspect in HCI research for the past 30 years. Based on this continuous and growing interest in HCI research, we find it to be a good time to explore if ‘time’ can be used as a way to structure and organize HCI research. In this paper, we make one such attempt based on a literature study in which we have focused on how time and temporality has been addressed in HCI research during the past 30 years. In our overview of the field, we explore how time and temporality has played out in HCI along the two dimensions of what and how it has been studied. Based on these two dimensions, we created a 4 × 4 matrix that allowed us to filter the material and categorize HCI research in relation to time and temporality. As a result of our explorations, we have identified a turn to temporality as a design material in HCI, an interest in methods for temporality studies in HCI and in temporality as a theoretical lens . We end with a discussion of some implications of our findings around the notions of (i) waves of time and temporality studies in HCI research, (ii) the potential use of the 4 × 4 matrix and (iii) the consequences of a more fundamental shift from things to events.
Brief DeNnitive Report

Interferon, or ig ina l ly de tec ted by its capac i ty to inhib i t viral rep l ica t ion in vi tro (1), has long been suspected to p l ay a role in viral infections in vivo (2). Thus , it was no ted tha t interferon a p p e a r e d at the r ight t ime a n d in the r ight p lace to l imi t viral growth (3). Nevertheless, a s imple corre la t ion be tween the a m o u n t of in terferon a n d the severi ty of a viral disease seems insufficient to make a s t rong case for in terferon as a defense mechanism. W i t h the ava i l ab i l i ty of po ten t an t i in te r feron ant isera , it became possible to demons t r a t e more convinc ingly tha t in terferon m a y de t e rmine viral pa thogen ic i ty (4-6). An interes t ing i l lus t ra t ion for this is inf luenza virus infect ion in mice ca r ry ing the d o m i n a n t allele Mx. Adul t an imals wi th this gene resist the le thal effect o f large doses of m o u s e a d a p t e d inf luenza viruses, t i ters of virus grown in thei r organs r ema in low, and in terferon is ha rd ly de tec tab le (7, 8). Nevertheless, inject ion o f po ten t ant i interferon an t ibodies renders Mx-bear ing mice as suscept ible to le thal inf luenza virus infect ion as non-Mx-bear ing mice (8). T h a t interferon has a pro tec t ive role in vivo, however, has so far not been demons t r a t ed direct ly. Because newborn Mx-bear ing mice are v i r tua l ly as suscept ible to or thomyxovi ruses as their Mx-negat ive coun te rpa r t s (9), we were ab le to de te rmine the efficacy o f in terferon in p ro tec t ing newborn mice differing at the Mx locus.
Dietary Diversity and Associated Factors Among Adult HIV Positive Patients on Anti-Retroviral Therapy in Public Hospitals of Kembata Tembaro Zone, Southern Ethiopia

Background: Nutrition is a significant factor in all stages of HIV. Dietary management of HIV-positive patients is key to supporting their capacity to continue participating in the workforce and contributing to socio-economic growth. Few studies have been conducted regarding this important public health problem of dietary diversity throughout the developing countries including Ethiopia. Therefore, this study assesses the magnitude and factors associated with dietary diversity among HIV-positive patients attending antiretroviral therapy (ART) clinics at Public Hospitals in Kembata Tembaro Zoni, Southern Ethiopia. Methods and Materials: An institutional-based cross-sectional study was conducted from January 01/2019 to 30/2019 on 341 adult HIV-positive patients on ART at two randomly selected public hospitals in the study area. A systematic random sampling technique was applied to select study subjects from each facility proportionally. Bivariable and multivariable logistic regression analyses were done to identify factors associated with individual dietary diversity. Logistic regression analysis with 95% confidence interval (CI) was estimated to measure the strength of association. Level of significance for statistical tests was set at p <0.05. Results: This study shows 60.1% (95% CI: 55–65) of patients had inadequate dietary diversity. Average monthly income of less than 1000 Ethiopian Birr (AOR: 1.82, 95% CI: 1.04–3.17), being female (AOR = 2.99, 95% CI: 1.67–5.37), duration of ART less than 1 year (AOR = 3.77, 95% CI: 1.42–10.02) and lack of dietary counseling (AOR =0.54, 95% CI: 0.30–0.97) were factors associated with low dietary diversity. Conclusion: Low dietary diversity was a major nutritional problem in HIV-positive patients. Low average monthly income, being female, duration of participants on ART, and lack of dietary counseling were the factors associated with low dietary diversity. To alleviate these problems, exceptional attention in nutritional care should be given to HIV-positive patients and they require appropriate counseling and support during early initiation of ART.
Factors affecting the acceptance and impact of human resource information systems (HRIS) : evidence from HR professionals in Libyan companies

This thesis investigates the attitudes of human resource professionals towards human resource information systems (HRIS) in order to better understand their enablers and effects on individuals and organisations. Focusing on factors influencing HRIS acceptance, the study identifies key dimensions relating to HRIS benefits specifically perceived usefulness and user satisfaction, organisational, social, and technical drivers of acceptance, and the consequences of satisfaction with HRIS for organisational behaviour. Drawing mainly on the theory of reasoned action TRA, the technology acceptance model and the DeLoan & McLean success model, a comprehensive multidimensional model is suggested. Data were collected from companies in the Libyan oil, gas and banking sectors and multivariate analysis was used to test the proposed theoretical framework. The findings show that top management support has a significant impact on perceived usefulness and satisfaction with HRIS. Furthermore, information quality, HRIS flexibility, ease of use, and IT staff support have considerable impacts on satisfaction with HRIS via perceived usefulness. Findings also show that social influence and the number of strategic applications also have a significant influence on user satisfaction. User satisfaction has the strongest impact on affective commitment compared to continuance and normative commitment. The study contributes in two ways. In terms of theoretical value, this study extends and develops theory of technology acceptance by relating social interactions, organisational support, and number of HRIS applications in terms of routine and strategic contexts and organisational behaviour. Second, it expands the technology acceptance model to examine and explain the perceptions and attitudes of HR professionals towards HRIS. There is also a practical contribution as Libya is a developing country characterised by a lack of understanding about technology adoption and the impact of technology on human resources activities. The findings inform top management, HR professionals and IT staff about the current practice of HRIS in a Libyan environment highlighting the variables (enablers and barriers) which can enhance or impede individual and organizational performance.
Diacylglycerol Signaling Regulates TCR-Induced a Kinase SAP-Mediated Inhibition of Diacylglycerol

Diacylglycerol kinases (DGKs) metabolize diacylglycerol to phosphatidic acid. In T lymphocytes, DGK a acts as a negative regulator of TCR signaling by decreasing diacylglycerol levels and inducing anergy. In this study, we show that upon costimulation of the TCR with CD28 or signaling lymphocyte activation molecule (SLAM), DGK a , but not DGK z , exits from the nucleus and undergoes rapid negative regulation of its enzymatic activity. Inhibition of DGK a is dependent on the expression of SAP, an adaptor protein mutated in X-linked lymphoproliferative disease, which is essential for SLAM-mediated signaling and contributes to TCR/CD28-induced signaling and T cell activation. Accordingly, overexpression of SAP is sufﬁcient to inhibit DGK a , whereas SAP mutants unable to bind either phospho-tyrosine residues or SH3 domain are ineffective. Moreover, phospholipase C activity and calcium, but not Src-family tyrosine kinases, are also required for negative regulation of DGK a . Finally, inhibition of DGK a in SAP-deﬁcient cells partially rescues defective TCR/CD28 signaling, including Ras and ERK1/2 activation, protein kinase C u membrane recruitment, induction of of activation, it may represent a novel pharmacological strategy
INS GFP/w human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells

Aims/hypothesis We aimed to generate human embryonic stem cell (hESC) reporter lines that would facilitate the characterisation of insulin-producing (INS + ) cells derived in vitro. Methods Homologous recombination was used to insert sequences encoding green fluorescent protein (GFP) into the INS locus, to create reporter cell lines enabling the prospective isolation of viable INS + cells. Results Differentiation of INS GFP/w hESCs using published protocols demonstrated that all GFP + cells co-produced insulin, confirming the fidelity of the reporter gene. INS-GFP + cells often co-produced glucagon and somatostatin, confirming conclusions from previous studies that early hESC-derived insulin-producing cells were polyhormonal. INS GFP/w hESCs were used to develop a 96-well format spin embryoid body (EB) differentiation protocol that used the recombinant protein-based, fully defined medium, APEL. Like INS-GFP + cells generated with other methods, those derived using the spin EB protocol expressed a suite of pancreatic-related transcription factor genes including ISL1 , PAX6 and NKX2.2 . However, in contrast with previous methods, the spin EB protocol yielded INS-GFP + cells that also co-expressed the beta cell transcription factor gene, NKX6 . 1 , and comprised a substantial proportion of monohormonal INS + cells. development of novel protocols for generating INS + cells from differentiating hESCs.
NSS_A_250586 309..324

Federico Salfi 1 Marco Lauriola Daniela Tempesta 1 Pierpaolo Calanna 3 Valentina Socci Luigi De Gennaro 4 Michele Ferrara 1 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; 2Department of Social and Developmental Psychology, Sapienza University of Rome, Rome, Italy; 3Department of Dynamic and Clinical Psychology, Sapienza University of Rome, Rome, Italy; 4Department of Psychology, Sapienza University of Rome, Rome, Italy Study Objectives: To evaluate the effects of total and partial sleep deprivation on reflection impulsivity and risk-taking in tasks requiring deliberative decision-making processes. Participants and Methods: Seventy-four healthy young adults were selected to participate in two independent experiments, each consisting of a crossover design. In Experiment 1, 32 participants were tested after one night of regular sleep (RS), and after one night of total sleep deprivation (TSD). In Experiment 2, 42 participants were tested following five nights of RS and after five nights of partial sleep deprivation (PSD), implying five hours of sleep per night. In both the experiments, two deliberative decision-making tasks were administered, involving different decision-making constructs. The Mosaic Task (MT) assessed reflection impulsivity, the tendency to gather information before making a decision. The Columbia Card Task cold version (CCTc) evaluated risk-taking propensity in a dynamic environment. Results: Unlike TSD, PSD led to an increment of reflection impulsivity and risk-taking. Nevertheless, analyses taking into account the individuals’ baseline (RS) performance showed consistent results between the two experimental sleep manipulations. Participants who gathered more information to make decisions in the MTwhen well-rested, then relied on less evidence under sleep loss, and more cautious participants in the CCTc tended to make riskier decisions. Conclusion: Results pointed to differential consequences of sleep deprivation depending on the habitual way to respond during decision-making involving deliberative reasoning processes. Results were interpreted according to a putative interaction between sleep loss effect and individual difference factors.