Miracle-dz/UniFAR-FTUs huggingface dataset:
Machine Learning for Active Portfolio Management

Machine learning (ML) methods are attracting considerable attention among academics in the field of finance. However, it is commonly believed that ML has not transformed the asset management industry to the same extent as other sectors. This survey focuses on the ML methods and empirical results available in the literature that matter most for active portfolio management. ML has asset management applications for signal generation, portfolio construction, and trade execution, and promising findings have been reported. Reinforcement learning (RL), in particular, is expected to play a more significant role in the industry. Nevertheless, the performance of a sample of active exchange-traded funds (ETF) that use ML in their investments tends to be mixed. Overall, ML techniques show great promise for active portfolio management, but investors should be cautioned against their main potential pitfalls. TOPICS: Big data/machine learning, portfolio construction, exchange-traded funds and applications, performance measurement Key Findings ▪ Machine learning (ML) methods have several advantages that can lead to successful applications in active portfolio management, including the ability to capture nonlinear patterns and a focus on prediction through ensemble learning. ▪ ML methods can be applied to different steps of the investment process, including signal generation, portfolio construction, and trade execution, with reinforcement learning expected to play a more significant role in the industry. ▪ Empirically, the investment performance of ML-based active exchange-traded funds is mixed.
Parental Depression After Preterm Birth: An Opportunity for Prevention

In this issue of Pediatrics, Garfield et al present new findings on depression symptoms among mothers and fathers who are parents of preterm infants during the NICU stay and the 30 days after discharge from the hospital. The data reveal that when preterm infants are hospitalized in the NICU, mothers are initially more depressed than fathers (higher scores on Edinburgh Postpartum Depression Scale), but maternal scores have decreased 30 days after discharge in contrast to paternal scores. With this study, the authors contribute to a growing literature on the importance of paternal postpartum depression better referred to as paternal perinatal affective disorder (PPAD), which encompasses both preand postnatal anxiety and depression. Whereas maternal postpartum depression (PPD) is increasingly recognized, PPAD is underscreened, underdiagnosed, and undertreated despite a prevalence of 8% to 20% in some surveys. Moreover, data suggest PPAD has adverse effects on mothers, their children, and the parental relationship. Risk factors include adverse childhood experiences, previous history of affective disorder, comorbid maternal PPD, unemployment, and low socioeconomic status, among others. PPAD peaks at 6 months postpartum, continues through 12 months postpartum, and may approach prevalence rates of 20% when preterm infants are less than 32 weeks' gestational age and 40% when nonresident fathers are included in surveys. Our improved understanding of the impact of safe, stable, nurturing relationships in buffering toxic stress makes the management of PPAD critically important for pediatricians. Recent studies of paternal grief highlight the presence of a term called “toxic masculinity,” whereby fathers are less likely to report sadness and weepiness and more likely to discourage breastfeeding and to demonstrate externalizing symptoms such as anger, irritability, substance use, and domestic violence. Although the Edinburgh Postpartum Depression Scale used in this study has been validated for fathers as well as for mothers, researchers are studying alternate screens that may better capture the symptoms with which fathers present. The Gotland scale is one such screen that attempts to capture the broader range of paternal symptoms of PPAD.
Drop-on-demand painting of highly viscous liquids

Graphical Abstract An on-demand painting system with a simple structure device that ejects highly viscous liquids as microjets is introduced. An impulsive motion of the container results in the ejection of a viscous liquid jet from the nozzle. This system enabled us to paint letters on a section of a car body using commercial car paint with a zero-shear viscosity of 100 $\textrm {Pa} \cdot \textrm {s}$. To understand the jet velocity, we conducted systematic experiments. Experimental results showed that the jet velocity increases with the ratio between the liquid depths in the container and the nozzle, up to approximately 30 times faster than the initial velocity. However, a linear relation between the jet velocity and the ratio predicted by the previous model, which considers only the pressure impulse, does not hold for the high length ratios since the actual position of the stagnation point is different from the position predicted by the previous model. By solving the Laplace equation and using the model proposed by Gordillo et al. (J. Fluid Mech., vol. 894, 2020, pp. A3–11), we reproduce the non-monotonic behaviour of the jet velocity as a function of the length ratio. For practical use, we improve the jet-velocity model by considering mass conservation as well as the pressure impulse.
The frailty phenotype in hemodialysis patients and its association with biochemical markers of mineral bone disorder, inflammation and nutrition

Abstract Introduction: Frailty is a state of increased vulnerability to physical stressors. It is common in patients with end-stage renal disease (ESRD) who are on hemodialysis (HD). The aim of this study was to analyze the presence of frailty phenotype among HD patients and to evaluate their interrelationship with different biochemical markers. Methods: For the frailty assessment the Frailty Phenotype by Fried et al. was used, where frailty was reported if three of the following criteria were met: unintentional weight loss, self-reported exhaustion, weakness, slow walking speed and low physical activity. From 281 HD patients, 126 patients were frail, 58 were pre-frail (two criteria were met) and the rest of the study population were robust (97 patients). BMI was calculated for all patients and venous blood samples were taken to determine laboratory parameters for bone alkaline phosphatase (BAP), phosphate (P), potassium (K), C-reactive protein (CRP) and albumin. Results: Patients who were on HD longer than 60 months have more characters of frailty. (p=0.019). A statistically significant positive correlations between frailty score and BAP (rho = 0.189; p = 0.001), and CRP (rho = 0.233; p < 0.001) were observed, and significant negative correlations between frailty score and albumin (rho = - 0.218; p < 0.001) and K (rho = - 0.198; p = 0.001). Conclusions: The associations of frailty with markers of mineral bone disorder, inflammation and nutrition indicate the importance of these parameters in the indirect assessment of the frailty phenotype in HD patients.
Is this really trigeminal neuralgia? Diagnostic re-evaluation of patients referred for neurosurgery

Abstract Objectives Patients with facial pain are sometimes referred for neurosurgical treatment with a poorly documented diagnosis of trigeminal neuralgia. In such cases, neurosurgery will usually not be helpful. We conducted a re-evaluation of the diagnosis in patients referred for neurosurgical treatment of presumed trigeminal neuralgia. Our objective was to find out why and how often misdiagnosis occurred. Methods A retrospective study was done in consecutive first-time patients referred for trigeminal neuralgia to our outpatient clinic in 2019. We used five ICHD-3-based clinical criteria to verify or exclude the diagnosis. In patients where trigeminal neuralgia was excluded, we established a diagnosis for their facial pain based upon medical history and a physical examination by a neurosurgeon – often supplemented with examination by an oral surgeon. Results Thirty-eight patients were referred for presumed trigeminal neuralgia. Only 17 of them fulfilled the five criteria and were diagnosed with trigeminal neuralgia. In 20 of the remaining 21 patients trigeminal neuralgia could be clearly excluded, while one of the patients had a periodontitis closely mimicking trigeminal neuralgia. In 14 of the 21 patients we diagnosed temporomandibular dysfunction or dental conditions. MRI scans had detected low-grade neurovascular contacts in 13 of the 21 patients, a finding that was clearly overestimated by the referring neurologists in seven patients. Conclusions Overdiagnosis of trigeminal neuralgia was common in patients referred for neurosurgery, mostly due to insufficient clinical evaluation combined with an overestimation of MRI-detected NVCs. The clinical diagnosis should be critically re-evaluated before recommending neurosurgery to patients referred for presumed trigeminal neuralgia.
The gift of homeschooling: Adult homeschool graduates and their parents conceptualize homeschooling in North Carolina

Abstract Although still a marginalized practice, homeschooling is on the rise internationally and across socio-economic groups. Moreover, the current Covid-19 pandemic has shifted additional attention to homeschooling. However, much of the available research is primarily concerned with the current day-to-day practice of homeschooling and little attention is paid to adult homeschool graduates. This exploratory study, based on qualitative interviews with mothers and adult children from 12 families, examines young adults’ overall evaluation of their past homeschooling experience and aims to understand how parents and children view the pros and cons of homeschooling in hindsight. The data analysis revealed that homeschoolers approach education more broadly than focusing strictly on the academic side and it identified the common theme of “gifting,” which challenges the prevailing conceptualization that homeschooling is a “sacrifice. ” Respondents viewed their homeschooling experience as a mutually beneficial process of giving and receiving rather than a unidirectional act of “sacrifice. ”
The experience of adults who were “unschooled” during their youth: A phenomenological approach

Abstract To better understand the experience of unschooling, non-directive in-depth interviews with five Quebec adults who had experienced it were conducted according to a phenomenological approach, revealing their perceptions of their educational experiences and their families, as well as their views of the world. Certain aspects of the testimonies corroborate the results of previous studies concerning self-directed learning, use of information technology, development of interests, and participation in a support group; others reveal limits when it comes to learning perseverance, pursuit of complex learning goals, school integration, and evaluation. The participants also spoke of family conflicts, parental control, negligence, and the influence of this experience on their views of society, work, the school system, and the role of government in education.
Economic impact of the EU Eastern enlargement on New Member States revisited: The role of economic institutions

Abstract The paper analyses the economic implications of the accession of New Member States (NMS) to the European Union (EU) in 2004 and 2007. The estimation effects of integration with the EU were carried out as a comparative case study using the synthetic control method (SCM) proposed by Abadie and Gardeazabal. Compared to previous studies analysing the effects of accession to the EU (Campos, Coricelli and Moretti), we check for the importance of the quality of economic institutions for the matching process of the analysed economies with their comparators. The results of the econometric analysis show a positive impact on the country performance 6 years and 12 years after accession to the EU. The gains from accession are large but not universal. For 5 of the 10 analysed countries the difference in levels of per capita gross domestic product (GDP) against the counterfactual is at least 30%.
Ageing and the Ipsilateral M1 BOLD Response: A Connectivity Study

Young people exhibit a negative BOLD response in ipsilateral primary motor cortex (M1) when making unilateral movements, such as button presses. This negative BOLD response becomes more positive as people age. Here we investigated why this occurs, in terms of the underlying effective connectivity and haemodynamics. We applied dynamic causal modelling (DCM) to task fMRI data from 635 participants aged 18-88 from the Cam-CAN dataset, who performed a cued button pressing task with their right hand. We found that connectivity from contralateral supplementary motor area (SMA) and dorsal premotor cortex (PMd) to ipsilateral M1 became more positive with age, explaining 44% of the variability across people in ipsilateral M1 responses. Neurovascular and haemodynamic parameters in the model were not able to explain the age-related shift to positive BOLD. Our results add to a body of evidence implicating neural, rather than vascular factors as the predominant cause of negative BOLD – while emphasising the importance of inter-hemispheric connectivity. This study provides a foundation for investigating the clinical and lifestyle factors that determine the sign and amplitude of the M1 BOLD response, which could serve as a proxy for neural and vascular health, via the underlying neurovascular mechanisms.
EEG alpha and pupil diameter reflect endogenous auditory attention switching and listening effort

Auditory attention describes a listeners focus on an acoustic source while they ignore other competing sources that might be present. In an environment with multiple talkers and background noise (i.e. the cocktail party effect), auditory attention can be difficult, requiring the listener to expend measurable cognitive effort. A listener will naturally interrupt sustained attention on a source when switching towards another source during conversation. This change in attention is potentially even more taxing than maintaining sustained attention due to the limits of human working memory, and this additional effort required has not been well studied. In this work, we evaluated an attention decoder algorithm for detecting the change in attention and investigated cognitive effort expended during attentional switching and sustained attention. Two variants of endogenous attention switching were explored: the switches either had in-the-moment decision making or a pre-defined attentional switch time. A least-squares, EEG-based, attention decoding algorithm achieved 64.1% accuracy with a 5-second correlation window and illustrated smooth transitions in the attended talker prediction through switches in sustained attention at approximately half of the analysis window size (2.2 seconds). The expended listening effort, as measured by simultaneous electroencephalography (EEG) and pupillometry, was also a strong indicator of switching. Specifically, centrotemporal alpha power [F(2, 18) = 7.473, P = 0.00434] and mean pupil diameter [F(2, 18) = 9.159, P = 0.0018] were significantly different for trials that contained a switch in comparison to sustained trials. We also found that relative attended and ignored talker locations modulate the EEG alpha topographic response. This alpha lateralization was found to be impacted by the interaction between experimental condition and whether the measure was computed before or after the switch [F(2,18) = 3.227, P = 0.0634]. These results suggest that expended listening effort is a promising feature that should be pursued in a decoding context, in addition to speech and location-based features.
Antibiotic treatment induces activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus

Antibiotics are widely applied for the treatment of bacterial infections, but their long-term use may lead to gut flora dysbiosis and detrimental effects on brain physiology, behavior as well as cognitive performance. Still, a striking lack of knowledge exists concerning electrophysiological correlates of antibiotic-induced changes in gut microbiota and behavior. Here, we investigated changes in the synaptic transmission and plasticity together with behaviorally-relevant network activities from the hippocampus of antibiotic-treated mice. The prolonged antibiotic treatment led to a strong reduction of myeloid cell pools in bone marrow, circulation and those surveilling the brain. Upon antibiotic treatment, circulating Ly6Chi inflammatory monocytes adopted a proinflammatory phenotype with increased expression of CD40 and MHC II. In the central nervous system, microglia displayed typical signs of activation with elevated CD40 and MHC II expression, as well as increased IL-6 and TNF production. Concomitantly, we detected a substantial reduction in the synaptic transmission in the hippocampal CA1 after antibiotic treatment. In line, carbachol-induced cholinergic gamma oscillation were reduced upon antibiotic treatment while the incidence of hippocampal sharp waves was elevated. These changes were associated with the global changes in the expression of neurotrophin nerve growth factor and inducible nitric oxide synthase, both of which have been shown to influence cholinergic functions. Overall, our study demonstrates that antibiotic-induced changes in the gut microbiome and immune cell function are associated with a drastic reduction in the synaptic transmission and gamma oscillations in the hippocampus, a brain region that is critically involved in mediation of innate and cognitive behavior.
Coherent mapping of position and head direction across auditory and visual cortex

Neurons in primary visual cortex (V1) may not only signal current visual input but also relevant contextual information such as reward expectancy and the subject’s spatial position. Such location-specific representations need not be restricted to V1 but could participate in a coherent mapping throughout sensory cortices. Here we show that spiking activity in primary auditory cortex (A1) and lateral, secondary visual cortex (V2L) of freely moving rats coherently represents a location-specific mapping in a sensory detection task performed on a figure-8 maze. Single-unit activity of both areas showed extensive similarities in terms of spatial distribution, reliability and position coding. Importantly, reconstructions of subject position on the basis of spiking activity displayed decoding errors that were correlated between areas in magnitude and direction. In addition to position, we found that head direction, but not locomotor speed or head angular velocity, was an important determinant of activity in A1 and V2L. Finally, pairs of units within and across areas showed significant correlations in instantaneous variability of firing rates (noise correlations). These were dependent on the spatial tuning of cells as well as the spatial position of the animal. We conclude that sensory cortices participate in coherent, multimodal representations of the subject’s sensory-specific location. These may provide a common reference frame for distributed cortical sensory and motor processes and may support crossmodal predictive processing.
Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae

Antibiotic resistance has become a major global issue. Understanding the molecular mechanisms underlying microbial adaptation to antibiotics is of keen importance to fight Antimicrobial Resistance (AMR). Aminoglycosides are a class of antibiotics that target the small subunit of the bacterial ribosome, disrupting translational fidelity and increasing the levels of misfolded proteins in the cell. In this work, we investigated the role of VchM, a DNA methyltransferase, in the response of the human pathogen Vibrio cholerae to aminoglycosides. VchM is a V. cholerae specific orphan m5C DNA methyltransferase that generates cytosine methylation at 5′-RCCGGY-3′ motifs. We show that deletion of vchM, although causing a growth defect in absence of stress, allows V. cholerae cells to cope with aminoglycoside stress at both sub-lethal and lethal concentrations of these antibiotics. Through transcriptomic and genetic approaches, we show that groESL-2 (a specific set of chaperonin-encoding genes located on the second chromosome of V. cholerae), are upregulated in cells lacking vchM and are needed for the tolerance of vchM mutant to lethal aminoglycoside treatment, likely by fighting aminoglycoside-induced misfolded proteins. Interestingly, preventing VchM methylation of the four RCCGGY sites located in groESL-2 region, leads to a higher expression of these genes in WT cells, showing that VchM modulates the expression of these chaperonins in V. cholerae directly through DNA methylation. AUTHOR SUMMARY Bacteria are organisms with a remarkable ability to adapt to several stress conditions, including to the presence of antibiotics. The molecular mechanisms underlying such adaptation lead, very often, to phenomena like antimicrobial tolerance and resistance, responsible for the frequent failure of antibiotic treatment. The study of these molecular mechanisms is thus an important tool to understand development of antimicrobial resistance in bacteria. In this work, we show that abrogating cytosine DNA methylation in Vibrio cholerae increases its tolerance to aminoglycosides, a class of antibiotics that cause protein misfolding. DNA methylation is known to affect gene expression and regulate several cellular processes in bacteria. Here we provide evidence that DNA methylation also has a more direct role in controlling antibiotic susceptibility in bacteria. Consequently, the study of bacterial DNA methyltransferases and DNA methylation should not be overlooked when addressing the problem of antimicrobial tolerance/resistance.