Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of oncoplasty in increasing breast conservation rates Post neo-adjuvant chemotherapy

Introduction The essential goal of neoadjuvant chemotherapy (NACT) is to downstage the primary tumor making it amenable for breast conservation surgery (BCS). However, since the safety of this surgery is paramount, post-NACT breast conservation rates remain low. As per the recommendation of the 2018 Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) overview of long-term post-NACT follow-up, we have devised a protocol for imaging, localization, rad-path analysis, and documentation of radiotherapy techniques to ensure the safety of post-NACT breast conservation. Methods This is a retrospective cohort of 180 breast cancer patients who received NACT and were operated on by a single surgical oncologist from 2015 to 2020. After selection based on published guidelines, patients were treated with neoadjuvant systemic (chemo or hormone) therapy. In cases where primary tumors responded and reduced to 1–2 cm in size mid-NACT, the residual tumors were localized by clips under ultrasound guidance and calcification was wire localized. All patients were treated using appropriate surgical and oncoplastic techniques where indicated. Negative margins were ensured by intra-operative rad-path analysis. Adjuvant chemotherapy and radiotherapy were given as per protocol. Results In 81 cases that required mastectomy at presentation, we were able to achieve a 72.8% post-NACT BCS rate with the help of oncoplasty. Overall, 142 of 180 (80%) patients were treated with breast conserving surgery of which 80% (121 of 142) were oncoplasty. Margins were assessed on intra-operative frozen and re-excised in the same setting. No positive margins were reported in final histopath of 142 breast conservation procedures. Post-operative complication rates after breast conservation in the first year were at 17% (24 of 142 including two major complications). Patient reported outcomes were satisfactory with increased satisfaction for breast conservation compared with immediate breast reconstruction. Discussion Employing oncoplastic breast surgery (OBS) techniques following stringent protocols for accurate localization of the residual tumor, intra-operative rad-path analysis, and adjuvant treatments, we show successful breast conservation in 72.8% of our mastectomy-qualified patients after downstaging by NACT. We also report satisfactory outcomes for post-NACT surgery, patient-reported satisfaction, and survival.
Accuracy of Human Papillomavirus (HPV) Testing on Urine and Vaginal Self-Samples Compared to Clinician-Collected Cervical Sample in Women Referred to Colposcopy

In the context of cervical cancer prevention, where human papillomavirus (HPV) infection is pivotal, HPV testing is replacing Pap Smear in primary screening. This transition offers an opportunity for integrating self-sampling to enhance coverage. We evaluated the accuracy of HPV testing using self-collected urine and vaginal samples, comparing them to physician-collected cervical swabs. From a cohort of 245 women with abnormal cytology, we collected self-sampled vaginal, urine, and clinician-administered cervical specimens. Employing Anyplex™II HPV28 assay, outcomes revealed HPV positivity rates of 75.1% (cervical), 78.4% (vaginal), and 77.1% (urine). Significant, hr-HPV detection concordance was observed between self-taken cervical samples and clinical counterparts (k = 0.898 for vaginal; k = 0.715 for urine). This study extends beyond accuracy, highlighting self-collected sample efficacy in detecting high-grade cervical lesions. The insight underscores self-sampling’s role in bolstering participation and aligns with WHO’s goal to eliminate cervical cancer by 2030.
Structures crustales d'afrique centrale deduites des anomalies gravimetriques et magnetiques : le domaine precambrien de la republique centrafricaine et du sud cameroun

Cette etude se propose d'interpreter les anomalies gravimetriques magnetiques du domaine precambrien de la republique centrafricaine et du sud cameroun. La reduction au pole des donnees magnetiques de la r. C. A. Montre que l'anomalie magnetique de bangui est l'addition de deux anomalies majeures qui recouvrent respectivement une unite archeenne et la chaine proterozoique inferieure de bogoin-ouham. La carte reduite a l'equateur suggere l'existence des sources ayant un allongement ew notable et des aimantations essentiellement induites. Les anomalies magnetiques se superposent a deux importantes signatures gravimetriques. Les zones de contacts entre le craton du congo et les zones mobiles panafricaines du sud cameroun et de l'est de la r. C. A. Montrent deux signatures gravimetriques inversees, caracterisees par un gradient majeur qui separe une anomalie positive, d'une anomalie negative de grandes longueurs d'ondes. L'interpretation quantitative montre que: le domaine archeen est traverse par une faille intracrustale ew a pendage nord qui recoupe en profondeur un large corps dense et magnetique. Ces deux structures sont integrees dans une evolution de type granite-greenstone belts. Dans la region de bogoin-ouham, le bloc crustal reactive au proterozoique inferieur, d'orientation submeridienne, se deverse vers l'est le long d'une discontinuite assimilee a une suture de collision. En profondeur, un corps dense et magnetique s'allonge parallelement aux unites de la chaine. La chaine de bogoin-ouham est interpretee comme une chaine de collision de type rift-intracratonique. Au sud cameroun et dans l'est de la r. C. A. , le craton plonge sous le domaine reactive au panafricain le long d'une discontinuite intracrustale. Les structures crustales modelisees presentent des caracteristiques deja reconnues ailleurs, notamment en afrique de l'ouest, qui permettent de les interpreter comme des structures issues d'une compression et d'une collision continentale
Empowering Lower Limb Disorder Identification through PoseNet and Artificial Intelligence

A novel approach is presented in this study for the classification of lower limb disorders, with a specific emphasis on the knee, hip, and ankle. The research employs gait analysis and the extraction of PoseNet features from video data in order to effectively identify and categorize these disorders. The PoseNet algorithm facilitates the extraction of key body joint movements and positions from videos in a non-invasive and user-friendly manner, thereby offering a comprehensive representation of lower limb movements. The features that are extracted are subsequently standardized and employed as inputs for a range of machine learning algorithms, such as Random Forest, Extra Tree Classifier, Multilayer Perceptron, Artificial Neural Networks, and Convolutional Neural Networks. The models undergo training and testing processes using a dataset consisting of 174 real patients and normal individuals collected at the Tehsil Headquarter Hospital Sadiq Abad. The evaluation of their performance is conducted through the utilization of K-fold cross-validation. The findings exhibit a notable level of accuracy and precision in the classification of various lower limb disorders. Notably, the Artificial Neural Networks model achieves the highest accuracy rate of 98.84%. The proposed methodology exhibits potential in enhancing the diagnosis and treatment planning of lower limb disorders. It presents a non-invasive and efficient method of analyzing gait patterns and identifying particular conditions.
Från förtätning till kluster – Borås utveckling som textilt centrum

Etableringen av Boras som textilt centrum skedde redan i borjan av 1900-talet. En fortatning av foretag inom de textila naringarna vaxte fram med en tidig bas i hemproduktion. Industriell produktio .
An Efficient Differentiated Routing Scheme for MEO/LEO-Based Multi-Layer Satellite Networks

Multi-Layer Satellite Networks (MLSNs) based on Medium and Low Earth Orbit (MEO and LEO) satellites have gained wide attention for a sake of their complementary advantages, offering improved flexibility and transmission efficiency. However, there are still several key issues to be addressed in terms of efficient routing, as related network topologies are dynamically changed, and Quality of Service (QoS) guarantee is impeded by the changing link quality and uneven traffic distribution. Thus, in this article, we mainly focus on the topology management and route planning for MLSNs, and propose a multi-objective-based Inter-layer Link Allocation (ILA) scheme for MEO and LEO satellites, along with a QoS-based Routing (QoSR) algorithm for on-demand traffic delivery. The aims are to significantly enhance the topology stability for transmission efficiency and improve user experience for different types of applications. Then, we implement the proposed scheme in Network Simulator NS-3 and evaluate its performance with other benchmarks. Extensive simulations were performed and related results indicate that the proposed scheme can sharply reduce the frequency of Inter-Layer Link (ILL) handovers and transmission power consumption, and significantly prompt the link utilization and transmission quality including end-to-end delay, packet loss rate, and flow finish rate.
Modoru: Clos nanosecond optical switching for distributed deep training [Invited]

Distributed deep training has become a significant consumer of bandwidth across datacenter-scale networks. The diverse parallel strategies employed in deep training require different communication patterns, necessitating the periodic adaptation of dynamic topologies. Since electrical switching approaches its capacity limit due to high bandwidths and has difficulties in regard to topology adaptation (i.e., logical and physical topologies are isomorphic), optical switching has become an attractive option to address these bottlenecks. In this paper, we propose Modoru, a wavelength- and datarate-agnostic Clos architecture with a switching speed of $O(10\;{\rm ns})$. Modoru is a drop-in replacement solution that has no constraints on achieving a high radix. To verify its topological flexibility, we also develop topology-as-a-service, which provisions sequentially dynamic topologies for training jobs and guarantees high topology availability over the entire network. Large-scale simulations show a basic $7.9 \times$ acceleration in deep training jobs using Modoru. Additionally, experiments on the Modoru prototype demonstrate acceleration of deep training jobs through the provisioning of adaptive topologies.
Human Prune Regulates the Metabolism of Mammalian Inorganic Polyphosphate and Bioenergetics

Inorganic polyphosphate (polyP) is an evolutionarily conserved and ubiquitous polymer that is present in all studied organisms. PolyP consists of orthophosphates (Pi) linked together by phosphoanhydride bonds. The metabolism of polyP still remains poorly understood in higher eukaryotes. Currently, only F0F1-ATP synthase, Nudt3, and Prune have been proposed to be involved in this metabolism, although their exact roles and regulation in the context of polyP biology have not been fully elucidated. In the case of Prune, in vitro studies have shown that it exhibits exopolyphosphatase activity on very short-chain polyP (up to four units of Pi), in addition to its known cAMP phosphodiesterase (PDE) activity. Here, we expand upon studies regarding the effects of human Prune (h-Prune) on polyP metabolism. Our data show that recombinant h-Prune is unable to hydrolyze short (13–33 Pi) and medium (45–160 Pi) chains of polyP, which are the most common chain lengths of the polymer in mammalian cells. Moreover, we found that the knockdown of h-Prune (h-Prune KD) results in significantly decreased levels of polyP in HEK293 cells. Likewise, a reduction in the levels of polyP is also observed in Drosophila melanogaster loss-of-function mutants of the h-Prune ortholog. Furthermore, while the activity of ATP synthase, and the levels of ATP, are decreased in h-Prune KD HEK293 cells, the expression of ATP5A, which is a main component of the catalytic subunit of ATP synthase, is upregulated in the same cells, likely as a compensatory mechanism. Our results also show that the effects of h-Prune on mitochondrial bioenergetics are not a result of a loss of mitochondrial membrane potential or of significant changes in mitochondrial biomass. Overall, our work corroborates the role of polyP in mitochondrial bioenergetics. It also demonstrates a conserved effect of h-Prune on the metabolism of short- and medium-chain polyP (which are the predominant chain lengths found in mammalian cells). The effects of Prune in polyP are most likely exerted via the regulation of the activity of ATP synthase. Our findings pave the way for modifying the levels of polyP in mammalian cells, which could have pharmacological implications in many diseases where dysregulated bioenergetics has been demonstrated.
GPU Accelerated Full Homomorphic Encryption Cryptosystem, Library, and Applications for IoT Systems

Deep learning, such as convolutional neural networks (CNNs), has been utilized in a number of cloud-based Internet of Things (IoT) applications. Security and privacy are two key considerations in any commercial deployment. Fully homomorphic encryption (FHE) is a popular privacy protection approach, and there have been attempts to integrate FHE with CNNs. However, a simple integration may lead to inefficiency in single-user services and fail to support many of the requirements in real-time applications. In this article, we propose a novel confused modulo projection-based FHE algorithm (CMP-FHE) that is designed to support floating-point operations. Then, we developed a parallelized runtime library based on CMP-FHE and compared it with the widely employed FHE library. Our results show that our library achieves faster speeds. Furthermore, we compared it with the state-of-the-art confused modulo projection-based library and the results demonstrated a speed improvement of 841.67 to 3056.25 times faster. Additionally, we construct a real-time homomorphic CNN (RT-HCNN) under the ciphertext-based framework using CMP-FHE, as well as using graphics processing units (GPUs) to facilitate acceleration. To demonstrate utility, we evaluate the proposed approach on the MNIST data set. Findings demonstrate that our proposed approach achieves a high accuracy rate of 99.13%. Using GPUs acceleration for ciphertext prediction results in us achieving a single prediction time of 79.5 ms. This represents the first homomorphic CNN capable of supporting real-time application and is approximately 58 times faster than Microsoft’s Lola scheme.
Evaluation of imaging methods in cerebral toxoplasmosis

Cerebral toxoplasmosis is a parasitic disease resulting, in most cases, from a reactivation of a latent cyst with Toxoplasma gondii. The disease mainly affects immunosuppressed individuals, such as HIV (human immunodeficiency virus)-infected patients. Diagnosis is based on specialized antibody testing, clinical symptoms, neuroimaging methods, and histological examination. The gold standard for diagnosis is a brain biopsy, but more often the response to treatment seen in clinical symptoms and neuroimaging studies is sufficient. The imaging features support the diagnosis of cerebral toxoplasmosis and help assess the effectiveness of treatment.
Modulation of immune response by nanoparticle-based immunotherapy against food allergens

The increasing prevalence of food allergies worldwide and the subsequent life-threatening anaphylactic reactions often have sparse treatment options, providing only symptomatic relief. Great strides have been made in research and in clinics in recent years to offer novel therapies for the treatment of allergic disorders. However, current allergen immunotherapy has its own shortcomings in terms of long-term efficacy and safety, due to the local side effects and the possibility of anaphylaxis. Allergen-specific immunotherapy is an established therapy in treating allergic asthma, allergic rhinitis, and allergic conjunctivitis. It acts through the downregulation of T cell, and IgE-mediated reactions, as well as desensitization, a process of food tolerance without any allergic events. This would result in a protective reaction that lasts for approximately 3 years, even after the withdrawal of therapy. Furthermore, allergen-specific immunotherapy also exploits several routes such as oral, sublingual, and epicutaneous immunotherapy. As the safety and efficacy of allergen immunotherapy are still under research, the exploration of newer routes such as intra-lymphatic immunotherapy would address unfulfilled needs. In addition, the existence of nanoparticles can be exploited immensely in allergen immunotherapy, which would lead to safer and efficacious therapy. This manuscript highlights a novel drug delivery method for allergen-specific immunotherapy that involves the administration of specific allergens to the patients in gradual increasing doses, to induce desensitization and tolerance, as well as emphasizing different routes of administration, mechanism, and the application of nanoparticles in allergen-specific immunotherapy.
Antioxidant Effect of the Ethyl Acetate Extract of Potentilla indica on Kidney Mitochondria of Streptozotocin-Induced Diabetic Rats

Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycemia. This state may lead to an increase in oxidative stress, which contributes to the development of diabetes complications, including diabetic kidney disease. Potentilla indica is a traditional medicinal herb in Asia, employed in the treatment of several diseases, including DM. In this study, we investigated the antioxidant effect of the ethyl acetate extract of Potentilla indica both in vitro and on kidneys of streptozotocin-induced diabetic male rats. Firstly, phytochemicals were identified via UPLC-MS/MS, and their in vitro antioxidant capabilities were evaluated. Subsequently, male Wistar rats were assigned into four groups: normoglycemic control, diabetic control, normoglycemic treated with the extract, and diabetic treated with the extract. At the end of the treatment, fasting blood glucose (FBG) levels, creatinine, blood urea nitrogen (BUN), and uric acid were estimated. Furthermore, the kidneys were removed and utilized for the determination of mitochondrial reactive oxygen species (ROS) production, mitochondrial respiratory chain complex activities, mitochondrial lipid peroxidation, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities. The in vitro findings showed that the major phytochemicals present in the extract were phenolic compounds, which exhibited a potent antioxidant activity. Moreover, the administration of the P. indica extract reduced creatinine and BUN levels, ROS production, and lipid peroxidation and improved mitochondrial respiratory chain complex activity and GSH-Px, SODk, and CAT activities when compared to the diabetic control group. In conclusion, our data suggest that the ethyl acetate extract of Potentilla indica possesses renoprotective effects by reducing oxidative stress on the kidneys of streptozotocin-induced diabetic male rats.
The Molecular and Function Characterization of Porcine MID2

Simple Summary Midline2 (MID2) is widely involved in development, innate immunity, cancer, viral infections, and disease, but its role in pigs remains unexplored. In this study, we describe the structure and function of porcine MID2. Our results revealed that the gene of pMID2 is highly conserved with human and other vertebrate animals and its expression is started by NF-κB. pMID2 is distributed in cell membrane and cytoplasm and widely expressed in pig lung, spleen, and other organs. Moreover, pMID2 could enhance the activity of the ISRE promoter, and is mainly involved in the JAK-STAT signaling pathway. The above findings provide useful information for studying the function of pMID2 in pigs. Abstract Midline2 (MID2/TRIM1) is a member of the tripartite motif-containing (TRIM) family, which is involved in a wide range of cellular processes. However, fundamental studies on porcine MID2 (pMID2) are still lacking. In this study, we identified and characterized the full length MID2 gene of pig (Sus scrofa). The sequence alignment analysis results showed that pMID2 had an N-terminal RING zinc-finger domain, BBC domain, and C-terminal COS box, FN3 motif, and PRY-SPRY domain that were conserved and similar to those of other vertebrates. Furthermore, pMID2 had the highest expression levels in porcine lung and spleen. Serial deletion and site-directed mutagenesis showed that the putative nuclear factor-κB (NF-κB) binding site may be an essential transcription factor for regulating the transcription expression of pMID2. Furthermore, the immunofluorescence assay indicated that pMID2 presented in the cell membrane and cytoplasm. To further study the functions of pMID2, we identified and determined its potential ability to perceive poly (I:C) and IFN-α stimulation. Stimulation experiments showed pMID2 enhanced poly (I:C)-/IFN-α-induced JAK-STAT signaling pathway, indicating that pMID2 might participate in the immune responses. In conclusion, we systematically and comprehensively analyzed the characterizations and functions of pMID2, which provide valuable information to explore the pMID2 functions in innate immunity. Our findings not only enrich the current knowledge of MID2 in IFN signaling regulation but also offer the basis for future research of pig MID2 gene.
PEMANTAUAN JUMLAH BAKTERI Coliform DI PERAIRAN SUNGAI PROVINSI LAMPUNG

Coliform merupakan golongan mikroorganisme yang lazim digunakan sebagai indikator dimana bakteri ini dapat menjadi sinyal untuk menentukan suatu sumber air telah terkontaminasi oleh patogen atau tidak. Salah satu penyebab terjadinya pencemaran air adalah mikrooganisme patogen yang terkandung dalam tinja karena dapat menularkan berbagai macam penyakit apabila masuk kedalam tubuh manusia. Penelitian ini bertujuan untuk mengetahui jumlah bakteri coliform di Sungai Provinsi Lampung di 8 Lokasi pengambilan titik sampling. Metodologi yang digunakan dalam penelitian ini adalah Pengambilan sampel dan survey lapangan, wawancara, serta analisis laboratorium. Hasil Pengujian menunjukkan jumlah koliform tertinggi terdapat pada lokasi Sungai I berkisar antara 25394-24413 JPT/100 mL, terendah terdapat pada lokasi Sungai VII berkisar antara 8564-12034 JPT/100 mL Hasil pengujian menunjukkan perairan Sungai Provinsi Lampung tercemar bakteri coliform yang telah melewati ambang batas persyaratan sungai kelas I (1000 Jumlah/100mL). Kata Kunci : Coliform, Sungai Provinsi Lampung, Jumlah bakteri
Application of gamification in Early Childhood Education and Primary Education: thematic analysis

In recent years, interest in the application of gamification in education has increased. Gamification is intended to stimulate students' thinking through game techniques, involving them in problem solving. The main aim of this study is to implement a thematic analysis on the use of gamification in early childhood and primary students. To this end, a systematic review was conducted using the PRISMA model in the Web of Science database, following inclusion and exclusion criteria on quantitative and qualitative experimental and quasi-experimental studies that explore gamification in early childhood education and primary school. 24 studies were analyzed. The results show that the investigations are aimed at improving academic and collaborative skills and increasing motivation with positive results. Furthermore, most of the studies involve students between 10 and 12 years of age and are developed in science subjects supported by technological applications and gamified elements. In conclusion, it has been found that gamification has been applied in early childhood and primary education for many areas and objectives. Likewise, as a didactic strategy, it has brought significant improvements in academic performance, motivation and autonomy, which makes it advisable to continue deepening its application. Keywords: gamification, early childhood education, primary education, thematic analysis