Miracle-dz/UniFAR-FTUs huggingface dataset:
Renoprotective Effect of Agalsidase Alfa: A Long-Term Follow-Up of Patients with Fabry Disease

Fabry disease is a rare lysosomal storage disorder caused by mutations in the GLA gene, which, without treatment, can cause significant renal dysfunction. We evaluated the effects of enzyme replacement therapy with agalsidase alfa on renal decline in patients with Fabry disease using data from the Fabry Outcome Survey (FOS) registry. Male patients with Fabry disease aged >16 years at agalsidase alfa start were stratified by low (≤0.5 g/24 h) or high (>0.5 g/24 h) baseline proteinuria and by ‘classic’ or ‘non-classic’ phenotype. Overall, 193 male patients with low (n = 135) or high (n = 58) baseline proteinuria were evaluated. Compared with patients with low baseline proteinuria, those with high baseline proteinuria had a lower mean ± standard deviation baseline eGFR (89.1 ± 26.2 vs. 106.6 ± 21.8 mL/min/1.73 m2) and faster mean ± standard error eGFR decline (−3.62 ± 0.42 vs. −1.61 ± 0.28 mL/min/1.73 m2 per year; p < 0.0001). Patients with classic Fabry disease had similar rates of eGFR decline irrespective of baseline proteinuria; only one patient with non-classic Fabry disease had high baseline proteinuria, preventing meaningful comparisons between groups. In this analysis, baseline proteinuria significantly impacted the rate of eGFR decline in the overall population, suggesting that early treatment with good proteinuria control may be associated with renoprotective effects.
Essential Computational Fluid Dynamics

PREFACE. 1 What Is CFD? 1.1. Introduction. 1.2. Brief History of CFD. 1.3. Outline of the Book. References and Suggested Reading. I Fundamentals. 2 Governing Equations of Fluid Dynamics and Heat Transfer. 2.1. Preliminary Concepts. 2.2. Mass Conservation. 2.3. Conservation of Chemical Species. 2.4. Conservation of Momentum. 2.5. Conservation of Energy. 2.6. Equation of State. 2.7. Equations in Integral Form. 2.8. Equations in Conservation Form. 2.9. Equations in Vector Form. 2.10. Boundary Conditions. References and Suggested Reading. Problems. 3 Partial Differential Equations. 3.1. Model Equations Formulation of a PDE Problem. 3.2. Mathematical Classification of PDE of Second Order. 3.3. Numerical Discretization: Different Kinds of CFD. References and Suggested Reading. Problems. 4 Basics of Finite Difference Approximation. 4.1. Computational Grid. 4.2. Finite Differences and Interpolation. 4.3. Approximation of Partial Differential Equations. 4.4. Development of Finite Difference Schemes. References and Suggested Reading. Problems. 5 Finite Volume Method. 5.1. Introduction and Integral Formulation. 5.2. Approximation of Integrals. 5.3. Methods of Interpolation. 5.4. Boundary Conditions. References and Suggested Reading. Problems. 6 Stability of Transient Solutions. 6.1. Introduction and Definition of Stability. 6.2. Stability Analysis. 6.3. Implicit versus Explicit Schemes-Stability and Efficiency Considerations. References and Suggested Reading. Problems. 7 Application to Model Equations. 7.1. Linear Convection Equation. 7.2. One-Dimensional Heat Equation. 7.3. Burgers and Generic Transport Equations. 7.4. Method of Lines Approach. 7.5. Implicit Schemes: Solution of Tridiagonal Systems by Thomas Algorithm. References and Suggested Reading. Problems. II Methods. 8 Steady-State Problems. 8.1. Problems Reducible to Matrix Equations. 8.2. Direct Methods. 8.3. Iterative Methods. 8.4. Systems of Nonlinear Equations. References and Suggested Reading. Problems. 9 Unsteady Problems of Fluid Flows and Heat Transfer. 9.1. Introduction. 9.2. Compressible Flows. 9.3. Unsteady Conduction Heat Transfer. References and Suggested Reading. Problems. 10 Incompressible Flows. 10.1. General Considerations. 10.2. Discretization Approach. 10.3. Projection Method for Unsteady Flows. 10.4. Projection Methods for Steady-State Flows. 10.5. Other Methods. References and Suggested Reading. Problems. III Art of CFD. 11 Turbulence. 11.1. Introduction. 11.2. Direct Numerical Simulation (DNS). 11.3. Reynolds-Averaged Navier-Stokes (RANS) Models. 11.4. Large-Eddy Simulation (LES). References and Suggested Reading. Problems. 12 Computational Grids. 12.1. Introduction: Need for Irregular and Unstructured Grids. 12.2. Irregular Structured Grids. 12.3. Unstructured Grids. References and Suggested Reading. Problems. 13 Conducting CFD Analysis. 13.1. Overview: Setting and Solving a CFD Problem. 13.2. Errors and Uncertainty. 13.3. Adaptive Grids. References and Suggested Reading. INDEX.
On the impulsive motion of a flat plate in a viscous fluid

The unsteady laminar boundary-layer flow induced by the impulsive motion of a semi-infinite flat plate along its length is investigated. It is found that, unlike Stewartson's (1951, 1960) conclusion, a power-series solution is possible using the ‘correctly stretched’ variables in the analysis. The small-time solution, which is developed in powers of the time, shows a smooth transition from the initial Rayleigh flow to the final Blasius flow without an essential singularity and, furthermore, its validity extends to the whole time domain. The series solution developed for large times, however, seems divergent and merely asymptotic. No evidence is found for the existence of an essential singularity in the solution as described by Stewartson.
Resilience in Web-Based Mental Health Communities: Building a Resilience Dictionary With Semiautomatic Text Analysis

Background Resilience is an accepted strengths-based concept that responds to change, adversity, and crises. This concept underpins both personal and community-based preventive approaches to mental health issues and shapes digital interventions. Online mental health peer-support forums have played a prominent role in enhancing resilience by providing accessible places for sharing lived experiences of mental issues and finding support. However, little research has been conducted on whether and how resilience is realized, hindering service providers’ ability to optimize resilience outcomes. Objective This study aimed to create a resilience dictionary that reflects the characteristics and realization of resilience within online mental health peer-support forums. The findings can be used to guide further analysis and improve resilience outcomes in mental health forums through targeted moderation and management. Methods A semiautomatic approach to creating a resilience dictionary was proposed using topic modeling and qualitative content analysis. We present a systematic 4-phase analysis pipeline that preprocesses raw forum posts, discovers core themes, conceptualizes resilience indicators, and generates a resilience dictionary. Our approach was applied to a mental health forum run by SANE (Schizophrenia: A National Emergency) Australia, with 70,179 forum posts between 2018 and 2020 by 2357 users being analyzed. Results The resilience dictionary and taxonomy developed in this study, reveal how resilience indicators (ie, “social capital,” “belonging,” “learning,” “adaptive capacity,” and “self-efficacy”) are characterized by themes commonly discussed in the forums; each theme’s top 10 most relevant descriptive terms and their synonyms; and the relatedness of resilience, reflecting a taxonomy of indicators that are more comprehensive (or compound) and more likely to facilitate the realization of others. The study showed that the resilience indicators “learning,” “belonging,” and “social capital” were more commonly realized, and “belonging” and “learning” served as foundations for “social capital” and “adaptive capacity” across the 2-year study period. Conclusions This study presents a resilience dictionary that improves our understanding of how aspects of resilience are realized in web-based mental health forums. The dictionary provides novel guidance on how to improve training to support and enhance automated systems for moderating mental health forum discussions.
Contributing factors to turnover intentions of early career project management professionals in construction

Abstract The construction industry is facing global skills shortages, with demand for certain roles (such as project managers) projected to outstrip supply over the next decade. With the industry serving as the backbone of the economy in many countries, this projected lack of skilled construction professionals poses dire consequences. This qualitative study investigated the early career transition of project management (PM) professionals into the construction industry. Semi-structured interviews were conducted with 18 employer representatives and 20 early career professionals to ascertain the factors affecting the turnover intentions of early career PM professionals in construction. From the perspective of the early participants in this study, the major factors affecting their intentions to leave were related to workplace culture: (i) bad workplace behaviour; (ii) high levels of work-related stress; and (iii) poor work-life balance. While employers also noted that bullying and long working hours contributed to early career PM professionals’ intentions to leave the industry, they believed that the key contributing factor was that young employees were seeking higher salaries. These findings on the need to improve workplace culture have the potential to positively influence the issue of early career retention within the construction industry.
Evaluation of Management Information Systems for Pharmaceutical Inventory Control at The Hospital

Hospital X is one of the hospitals in Lampung that has implemented management information systems for pharmacy since 2016, has not yet been evaluated, and there are several obstacles, such as the absence of warnings for out-of-stock drugs and drug procurement planning is still calculated manually. This research was a descriptive study with a cross-sectional approach to the management information system of pharmaceutical inventory control. This research data comes from the distribution of the De Lone and McLean questionnaires and the results of structured interviews to support system development. Based on calculations using a predetermined formula, it is said that the level of respondents' satisfaction with management information systems drug inventory control is in the medium category, but is still very far from the high satisfaction category, so further interviews are needed. After developing a pharmaceutical inventory control management information system, there were 18 participants from the pharmacy participated in training and self-testing for eight days. Based on the research that has been done, it can be concluded that the level of the respondent's satisfaction category has increased its variables, the satisfaction variable has a perception of satisfaction in the medium category of 100% and the high category of 0%, but after developing a pharmaceutical inventory control system, the satisfaction level of respondents in the high category has increased was 27.78%, so the development of a control management information system needs to be done. This
Hydrodynamics and Nonlinear Instabilities

Preface Overview 1. An introduction to hydrodynamics Bernard Castaing 2. Hydrodynamical instabilities in open flows P. Huerre and M. Rossi 3. Asymptotic techniques in nonlinear problems: some illustrative examples Vincent Halim 4. Pattern forming instabilities Stephan Fauve 5. An introduction to the instability of flames, shocks and detonations G. Joulin and P. Vidal.
Simultaneous production of an exopolysaccharide and chitosan by Aspergillus quadrilineatus using response surface methodology

This study was aimed to reduce the production cost of fungal exopolysaccharides by increasing the yield and extracting chitosan from the fungal wastes produced simultaneously. Aspergillus quadrilineatus was isolated as well as identified morphologically and by molecular analyses (GenBank Accession No. MT742630.1). One-variable-at-a-time method was combined with response surface methodology to
Extraction of Antioxidants from Aronia mitschurinii Juice Using Macroporous Resins

Antioxidants play a vital role in the human body by defending cells from damage caused by free radicals, highly reactive products of oxidation reactions. A major source of antioxidants is fruits and vegetables. Aronia mitschurinii, a breed created at the end of the 19th century by crossbreeding wild Aronia melanocarpa and Russian Mountain Ash, produces fruits with one of the highest known content of hydrophilic antioxidants. Aronia fruit contains a potent blend of anthocyanins, polyphenols, and flavonoids. The most popular way of consuming the fruit is through juicing. Yet, due to very high concentrations of tannins in the juice, very few food-related applications have been developed. Resin extraction of antioxidants provides an alternative for utilizing valuable phytochemicals from crops for applications in the food industry as nutraceutical supplements and more. To increase the market value of the plant, it is important to determine what resins can extract the optimum concentration of antioxidants from aronia juice, pulp, and whole berries. We have shown that macroporous resins such as Amberlite XAD 1180N, Amberlite XAD 7HP, Amberlite XAD 761, and Amberlite FPX66, which have been reported to be effective in extracting the anthocyanins and polyphenols from other fruit juices, skins of red grapes, and the wild breed, are also effective for use in juice, pulp, and whole fruits of Aronia mitchurinii. However, the extremely high content of antioxidants presents a challenge to obtaining high recovery; a notable change in the juice/resin ratio is required to obtain a higher recovery value. Our results showed that Amberlite FPX66 was the best at extracting anthocyanins, polyphenols, and flavonoids from aronia juice. A separate experiment conducted to determine how to optimize the efficiency of FPX66 extraction revealed that increasing the resin/juice ratio increased the percent recovery of anthocyanins from aronia juice. Moreover, we have compared recovery between juice, pulp, and whole aronia berries and batch versus column extraction.
Effects of mixing state on water-uptake properties of ammonium sulfate – Organic mixtures

Abstract Aerosol particles in the atmosphere have the ability to uptake water and form droplets. The droplets formed can interact with solar radiation (indirect effect of aerosols) and influence the net radiative forcing. However, the magnitude of change in radiative forcing due to the indirect effect of aerosols remains uncertain due to the high variance in aerosol composition and mixing states, both spatial and temporally. As such, there is a need to measure the water-uptake of different aerosol particle groups under controlled conditions to gain insight into the water-uptake of complex ambient systems. In this work, the water-uptake (hygroscopicity) of internally and externally mixed ammonium sulfate – organic binary mixtures were directly measured via three methods and compared to droplet growth prediction models. We found that subsaturated water-uptake of ammonium sulfate-organic mixtures agreed with their supersaturated hygroscopicities, and mixing state information was able to be retrieved at both humidity regimes. In addition, we found that solubility-adjusted models may not be able to capture the water-uptake of viscous particles, and for soluble organic aerosol particles, bulk solubility may not be comparable to their solubility in a droplet. This work highlights the importance of using multiple complementary water-uptake measurement instruments to get a clearer picture of mixed aerosol particle hygroscopicity, especially for increasingly complex systems. Copyright © 2022 American Association for Aerosol Research Graphical Abstract SYNOPSIS STATEMENT This work provides water-uptake measurements of mixed aerosol particles that are prevalent in the atmosphere that can be useful in improving climate models.
Free Recall of Emotional Word Lists in Arabic-English Bilinguals

: This paper tries to investigate if there is a difference in the memory recall of emotional words between Arabic-English bilinguals. The methodology involves an experiment of free-recall responses to emotional word stimuli by 68 Egyptian Arabic-English bilinguals where the Arabic language is their native language (L1) and English language is their second language (L2). The participants divided into early English learners who acquired L2 at year 6, and late English learners who acquired L2 at year 12. A design of 2 x 2 x 3 three-way mixed ANOVA was administered with three independent variables; the group of L2 language acquisition (i.e., early, and late), the language (i.e., Arabic, English), and the emotionality of words (i.e., positive, negative, and neutral). The result showed no significant difference between late and early L2 learners in memory recall. However, there was significant main effect of language as well as main effect of emotionality on memory recall. Furthermore, the results showed significant interaction between emotionality and whether subjects acquired L2 early or late, as well as the result showed significant interaction between language and emotionality. Finally, the results showed significant interaction between the language, emotionality, and whether the subjects acquired L2 early or late.
Recycled waste plastic for extending and modifying asphalt binders

Plastic drink bottles, single-use plastic bags and other waste plastics have a significant impact on the environment. Consequently, there is global interest in recycling and reuse of waste plastics. Significant progress has been made towards the incorporation of waste plastics into building and construction materials, although this has focussed mainly on cement and concrete applications. This paper assesses the use of three commercially available recycled plastic products for bituminous binder extension and modification in asphalt mixtures. Using a drymixing process, shredded and pelletised recycled waste plastics replace 6% of the binder volume. Comparative laboratory testing of two typical UK asphalt mixtures indicated that asphalt containing the recycled waste plastic products showed improved deformation resistance and fracture resistance compared to conventional 40/60 penetration grade binder. The viability of imported recycled plastic waste use in Australian asphalt mixtures was also evaluated. One of the three recycled plastic products is expected to be a cost effective alternate to M1000 or A35P and another is expected to be a viable alternate to A20E, at a significant cost saving. Partial replacement, without performance enhancement, of C320 bitumen is not viable due to the high cost of recycled waste plastic importation. However, partial C320 replacement may become viable with the introduction of local recycled plastic processing in the future. The findings of this research require validation by objective comparison to Australian asphalt mixtures produced with common Australian asphalt binders, as well as confirmation of likely importation costs. Verification of consistent product digestion and distribution through drumbased asphalt production plants is also required.
Algorithm for Evaluating the Intervention Effect of Physical Exercise on Stress Groups

Mental health is always a concern, especially for students, as they are more prone to stress based on educational burden and competition. Among student groups at different levels, college students are of serious concern as they are an essential pillar of social and economic development, and their mental health has been the society’s focus in recent years. With the increasing population leading to the increasing number of college students in our country, the competition for professional learning is also becoming fiercer, seriously affecting students’ mental health. Little attention has been paid to adverse effects on mental health or effective mitigation strategies to improve mental health in recent years. However, it is still of grave concern as the stress among students leads to depression, several diseases, and ultimately death. The purpose of this study is to evaluate the effect of physical exercise interventions on stress groups irrespective of their (educational) levels. Physical activity can effectively release stress and is an excellent way to regulate emotions. For this reason, it is a task that the current universities must complete to strengthen physical exercise in students’ mental health education. The paper highlights the impact of various social pressures on students’ mental health, understands its underlying mechanisms, and explores feasible mitigation strategies for improving and schooling students’ mental health. This paper proposes an integrated evaluation-based algorithm to explore the model of the intervention effect of physical exercise on college students. It takes college students as the representative of stress groups. The results show that daily physical activities can effectively relieve the stress of college students.
Effects of Doxorubicin and Nanoparticle Zinc oxide on DNA damage and Hepatotoxicity induced by Carbon tetrachloride in rats.

The purpose of this study is to determine the effects of doxorubcin and nanoparticle Zinc oxide in normal and hepatotoxicity induced by Carbon tetrachloride(CCl4 ) in rats. The nanoparticle of ZnO (ZnO-NPs) were prepared by wet reaction of Zn acetate and sodium hydroxide. The prepared ZnO NPs were identified and characterized by Scanning Electron Microscope (SEM) with Energy Dispersire X-ray spectrometer ( EDX ) Fourier Transmitter Infra Red ( FTIR ) and UV visible , the structure of particles was 100 nm. The investigated parameters were Liver enzymes, Protein electrophoresis and DNA gel electrophoresis in normal and injected rats by CCl4. Atotal of forty eight adult male albino rats (130-165 g) were divided into 8 groups, each of 6 rats. Group one was kept as a control –ve, second and third groups were injected intraperitoneally with DOX(6mg/kgb.wt) and nZnO(5mg/kgb.wt) respectively for 3 successive days. While fourth group was injected intraperitoneally nZnO followed by DOX for the same period. On the other hand, other four groups were injected subcutaneously with CCL4 50% (0.1 ml/100g.b.wt.twice/week for two weeks )to induce DNA damge and hepatotoxicity. One of this groups was kept as a control +ve (CCL4 groups). Sexth and seventh groups were injected intraperitoneally with DOX (6 mg/kgb.wt) and nZnO (5 mg/kgb.wt) respectively for the same period. While eighth group was injected intraperitoneally nZnO followed by DOX for the same period. At the end of experimental period, blood samples were collected from each rat for biochemical analysis and the rats were sacrificed to illustrate DNA damage in hepatocytes. Subcutaneous injection of CCL4 caused significant increase in serum levels of aspartateaminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphate (ALP) while the levels of malondialdhyde (MDA), Total Antioxidant Capacity (TAC), albumin and globulin were significantly decreased . The smear on agarose gel had been observed in CCL4 injected groups indicating random DNA fragmentation. Rats were injected DOX showed similar changes. NZnO significantly restored the serum levels of the biochemical parameters and DNA damage directed toward to normal as compared with the control +ve group (injected with CCl4). Thus, it can be concluded that zinc oxide nanoparticles followed doxorubicin intraperitoneally Egypt. J. Chem. Environ. Health, 1 (1):866-882 (2015) 688 injection improved the alteration of some serum biochemical parameters and DNA damge induced by CCL4.