Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling Movement of Gas-Static Bearings

The competitiveness of gas-static sliding bearings, which are assemblies of cutting-edge machines, in particular, precision metal-cutting machines, largely depends on their creation rapidity, which is determined by their mobility of modeling and quality of theoretical study for the later use in designing constructions. The objective is to develop a computer-aided mobile modeling technology for designing the gas-static bearings, which enables quick calculation and study of their static characteristics, quality criteria for their dynamics, and drawing-up recommendations for rapid designing of bearings to ensure performance characteristics and appropriate dynamics quality of designs through automation of procedures, their mathematical modeling, and theoretical study. As a result, there has been developed a technology concept for modeling of gas-static bearings and numerical methods, which allow us to find a solution for exploring tasks with a desirable accuracy. Based on the approximate and proposed numerical methods, the developed modeling technology rapidity was studied, and high comparative efficiency of this technology was found. Practical relevance of technology lies in significant acceleration of modeling processes, calculation and study of static and dynamic characteristics of gas-static bearings that is provided by application of developed methods, algorithms, and modeling technology. There are also reducing the complexity of research processes, and the capability for quick learning of complex bearing structures rapid exploration of which is hard or inconceivable using the traditional “manual” technology.
Interactions between physical forcing, water circulation and phytoplankton dynamics in a microtidal estuary

Memoria de tesis doctoral presentada por Clara Llebot Lorente para optar al grado de Doctora por la Universidad de Las Palmas de Gran Canaria (ULPGC), realizada bajo la direccion de la Dra. Marta Estrada Miyares y del Dr. Jordi Sole Olle del Institut de Ciencies del Mar (ICM-CSIC). -- 212 pages
Tetraethylammonium trichlorido(N,N′-dimethylformamide-κO)zinc

The title complex salt, (C8H20N)[ZnCl3(C3H7NO)], contains one [Et4N]+ cation (Et is ethyl) and one [ZnCl3(DMF)]− anion (DMF is dimethylformamide). In the anion, the zinc atom is tetrahedrally coordinated by a DMF ligand via the O atom and by three terminal Cl atoms. The average Zn—Cl bond length and Cl—Zn—Cl angle are 2.243 (11) Å and 114 (3)°, respectively.
Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells1

Currently, it is not understood how the specificity of the TCR guides CD4+ T cells into the conventional lineage (Tconv) vs directing them to become regulatory (Treg) cells defined by the Foxp3 transcription factor. To address this question, we made use of the “Limited” (LTD) mouse, which has a restricted TCR repertoire with a fixed TCRβ chain and a TCRα chain minilocus. The TCR repertoires of Tconv and Treg cells were equally broad, were distinct, yet overlapped significantly, representing a less strict partition than previously seen between CD4 and CD8 T cells. As a group, the CDR3α motifs showed a significant trend to higher positive charge in Treg than in Tconv cells. The Tconv and Treg repertoires were both reshaped between thymus and periphery. Reducing the array of peptides presented by MHC class II molecules by introducing the H2-DMo/o mutation into the LTD mouse led to parallel shifts in the repertoires of Tconv and Treg cells. In both cases, the CDR3α elements were entirely different and strikingly shortened, relative to normal LTD mice. These peculiar sequences conferred reactivity to wild-type MHC class II complexes and were excluded from the normal repertoire, even among Treg cells, indicating that some forms of self-reactivity are incompatible with selection into the Treg lineage. In conclusion, the Treg repertoire is broad, with distinct composition and characteristics, yet significantly overlapping and sharing structural constraints with the repertoire of conventional CD4+ T cells.
Waning of maternal antibodies against measles, mumps, rubella, and varicella in communities with contrasting vaccination coverage.

BACKGROUND The combined measles, mumps, and rubella (MMR) vaccine has been successfully administered for >20 years. Because of this, protection by maternal antibodies in infants born to vaccinated mothers might be negatively affected. METHODS A large cross-sectional serologic survey was conducted in the Netherlands during 2006-2007. We compared the kinetics of antibody concentrations in children and women of childbearing age in the highly vaccinated general population with those in orthodox Protestant communities that were exposed to outbreaks. RESULTS The estimated duration of protection by maternal antibodies among infants in the general population, most of whom were born to vaccinated mothers, was short: 3.3 months for measles, 2.7 months for mumps, 3.9 months for rubella, and 3.4 months for varicella. The duration of protection against measles was 2 months longer for infants born in the orthodox communities, most of whom had unvaccinated mothers. For rubella, mothers in the orthodox communities had higher concentrations of antibodies as compared to the general population. CONCLUSION Children of mothers vaccinated against measles and, possibly, rubella have lower concentrations of maternal antibodies and lose protection by maternal antibodies at an earlier age than children of mothers in communities that oppose vaccination. This increases the risk of disease transmission in highly vaccinated populations.
Transferrin-polycation conjugates as carriers for DNA uptake into cells.

We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated endocytosis to carry DNA macromolecules into cells. We accomplished this by conjugating the iron-transport protein transferrin to polycations that bind nucleic acids. Human transferrin, as well as the chicken homologue conalbumin, has been covalently linked to the small DNA-binding protein protamine or to polylysines of various sizes through a disulfide linkage. These modified transferrin molecules maintain their ability to bind their cognate receptor and to mediate efficient iron transport into the cell. The transferrin-polycation molecules form electrophoretically stable complexes with double-stranded DNA, single-stranded DNA, and modified RNA molecules independent of nucleic acid size (from short oligonucleotides to DNA of 21 kilobase pairs). When complexes of transferrin-polycation and a bacterial plasmid DNA containing the gene for Photinus pyralis luciferase are supplied to eukaryotic cells, high-level expression of the luciferase gene occurs, demonstrating transferrin receptor-mediated endocytosis and expression of the imported DNA. We refer to this delivery system as "transferrinfection. "
Statistical inference on mean dioptric power: hypothesis testing and confidence regions

It has not hitherto been possible to apply formal methods of statistical analysis to data on dioptric powers. The solution to the basic statistical problem is now provided in this paper. Recognition of the matric‐variate nature of dioptric power allows calculation of sample means and variance‐covariances. These in turn can be used to calculate a statistic for testing hypotheses on population means and for obtaining confidence regions for those means. In a graphical representation of dioptric power the confidence region turns out to be an ellipsoid centred on the mean of the sample of dioptric powers. The theory is illustrated by means of numerical examples. Singularity of the variance‐covariance matrix may occur especially when the sample is small. When it does occur it is the cause of some difficulty in applying the statistics. Nevertheless singularity is rare in practical situations and can usually be avoided simply by increasing the size of the sample. Singularity, therefore, is not treated fully in this paper. Dioptric power is essentially four‐dimensional in character but in practice a three‐dimensional subspace is almost always sufficient. To avoid the difficulty of having to represent four‐dimensional shapes and to avoid the complication of singularity (which is the rule rather than the exception in practice in four‐space) only the common three‐dimensional problem is considered in detail.
Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins

Abstract Double-stranded RNA-binding domains (dsRBDs) are commonly found in modular proteins that interact with RNA. Two varieties of dsRBD exist: canonical Type A dsRBDs interact with dsRNA, while non-canonical Type B dsRBDs lack RNA-binding residues and instead interact with other proteins. In higher eukaryotes, the microRNA biogenesis enzyme Dicer forms a 1:1 association with a dsRNA-binding protein (dsRBP). Human Dicer associates with HIV TAR RNA-binding protein (TRBP) or protein activator of PKR (PACT), while Drosophila Dicer-1 associates with Loquacious (Loqs). In each case, the interaction involves a region of the protein that contains a Type B dsRBD. All three dsRBPs are reported to homodimerize, with the Dicer-binding region implicated in self-association. We report that these dsRBD homodimers display structural asymmetry and that this unusual self-association mechanism is conserved from flies to humans. We show that the core dsRBD is sufficient for homodimerization and that mutation of a conserved leucine residue abolishes self-association. We attribute differences in the self-association properties of Loqs, TRBP and PACT to divergence of the composition of the homodimerization interface. Modifications that make TRBP more like PACT enhance self-association. These data are examined in the context of miRNA biogenesis and the protein/protein interaction properties of Type B dsRBDs.
Learning Robot Motion Control from Demonstration and Human Advice

As robots become more commonplace within society, the need for tools that enable non-robotics-experts to develop control algorithms, or policies, will increase. Learning from Demonstration (LfD) offers one promising approach, where the robot learns a policy from teacher task executions. In this work we present an algorithm that incorporates human teacher feedback to enable policy improvement from learner experience within an LfD framework. We present two implementations of this algorithm, that differ in the sort of teacher feedback they provide. In the first implementation, called Binary Critiquing (BC), the teacher provides a binary indication that highlights poorly performing portions of the execution. In the second implementation, called Advice-Operator Policy Improvement (A-OPI), the teacher provides a correction on poorly performing portions of the student execution. Most notably, these corrections are continuous-valued and appropriate for low level motion control action spaces. The algorithms are applied to validation domains, one simulated and one a Segway RMP platform. For both, policy performance is found to improve with teacher feedback. Specifically, with BC learner execution success and efficiency come to exceed teacher performance. With A-OPI task success and accuracy are shown to be similar or superior to the typical LfD approach of correcting behavior through more teacher demonstrations.
Ibis: Real-world problem solving using real-world grids

Ibis is an open source software framework that drastically simplifies the process of programming and deploying large-scale parallel and distributed grid applications. Ibis supports a range of programming models that yield efficient implementations, even on distributed sets of heterogeneous resources. Also, Ibis is specifically designed to run in hostile grid environments that are inherently dynamic and faulty, and that suffer from connectivity problems. Recently, Ibis has been put to the test in two competitions organized by the IEEE Technical Committee on Scalable Computing, as part of the CCGrid 2008 and Cluster/Grid 2008 international conferences. Each of the competitions' categories focused either on the aspect of scalability, efficiency, or fault-tolerance. Our Ibis-based applications have won the first prize in all of these categories. In this paper we give an overview of Ibis, and — to exemplify its power and flexibility — we discuss our contributions to the competitions, and present an overview of our lessons learned.
Enhancing search results of concept annotated documents

Concepts describing documents can offer a way for semantically grounding these documents. The goal of the work presented in this paper is to investigate making use of such concepts and the existence of an ontology in order to enhance search results in a known domain. So in this work we experiment with various techniques to achieve this goal. Experiments presented in this paper show that relying only on concept indexing and matching leads to degraded search results. This paper proposes an integrated approach based on augmenting a classical search technique with a concept based one which utilizes semantic information to improve the search results. A detailed discussion of the reported experimental results is also presented.
A Sensor for Urban Driving Assistance Systems Based on Dense Stereovision

The urban driving environment is a complex and demanding one, requiring increasingly complex sensors for the driving assistance systems. These sensors must be able to analyze the complex scene and extract all the relevant information, while keeping the response time as low as possible. The sensor presented in this paper answers to the requirements of the urban scenario through a multitude of detection modules, built on top of a hybrid (hardware plus software) dense stereo reconstruction engine. The sensor is able to detect and track clothoid and non-clothoid lanes, cars, pedestrians (classified as such), and drivable areas in the absence of lane markings. The hybrid stereovision engine and the proposed detection algorithms allow accurate sensing of the demanding urban scenario at a high frame rate.
Quantification of weathering

Weathering and especially future weathering after construction of a slope is a main cause for failure of a slopeduringitsengineering life-time. In the course of developing a rock mass classification system for slope stability, large quantities of data have been collected for quantification of past and future weathering influences on rock mass geotechnical parameters. This research resulted in the determination of reduction values related to the degrees of rock mass weathering as described by the British Standard, that give the reduction of a geotechnical rock mass parameter if the degreeof weathering increases. The large quantity of data allowed for a statistical analysis that assesses the reliability ofthe valuesfound for the reduction values. These reduction factors are developed in the context of a slope classification system, however, there is no reason that these reduction factors are not valid for other engineering projects in or on rock masses.
Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis

The mechanism for Myc-induced genetic instability is not well understood. Here we show that sublethal activation of Caspase-3 plays an essential, facilitative role in Myc-induced genomic instability and oncogenic transformation. Overexpression of Myc resulted in increased numbers of chromosome aberrations and γH2AX foci in non-transformed MCF10A human mammary epithelial cells. However, such increases were almost completely eliminated in isogenic cells with CASP3 gene ablation. Furthermore, we show that endonuclease G, an apoptotic nuclease downstream of Caspase-3, is directly responsible for Myc-induced genetic instability. Genetic ablation of either CASP3 or ENDOG prevented Myc-induced oncogenic transformation of MCF10A cells. Taken together, we believe that Caspase-3 plays a critical, unexpected role in mediating Myc-induced genetic instability and transformation in mammalian cells. DOI: http://dx.doi. org/10.7554/eLife.26371. 001
The Gender Gap

ABSTRACT Prior research suggested that males are more selective information processors and females are more detailed processors, but effects on advertising attention and attitudes have been largely unstudied. In particular, mere-exposure effects (more favorable attitudes with little or no advertising attention) are expected to be more pronounced for males than for females, due to less comprehensive heuristic processing by males. Furthermore, gender differences in hemispheric (brain) processing are predicted, with males expected to have more favorable attitudes from advertisements on the left of the page and females expected to have more favorable attitudes from advertisements on the right of the page. Hypothesized marketing outcomes are generally supported. Management implications are discussed.
A Low Cost circuit level fault detection technique to Full Adder design

This paper proposes a Low Cost circuit level Fault Detection technique called LCFD for a one-bit Full Adder (FA) as the basic element of adder circuits. To measure the fault detection coverage of the proposed technique, we conduct an exhaustive circuit level fault injection experiment on all susceptible nodes of a FA. Experimental results show that the LCDF technique can detect about 83% of injected faults while having only about 40% area and 22% power consumption overheads. In the LCDF technique, the fault detection latency does not affect the latency of the FA, since the error detection is done in parallel with the addition.
Implementation of Mapping Algorithm for SLAM Operation

An autonomous mobile robot needs a map of the environment for navigation. Simultaneous Localization and Mapping (SLAM) is essential for autonomous navigation, path planning and obstacle avoidance. This paper gives an implementation of a mapping algorithm meant for SLAM operation. Indeed, it is one of the essential bricks to build an autonomous robot that can evolve in an unknown environment. A 2D map is generated as a result of the operation.
DNA double-strand breaks with 5′ adducts are efficiently channeled to the DNA2-mediated resection pathway

DNA double-strand breaks (DSBs) with 5′ adducts are frequently formed from many nucleic acid processing enzymes, in particular DNA topoisomerase 2 (TOP2). The key intermediate of TOP2 catalysis is the covalent complex (TOP2cc), consisting of two TOP2 subunits covalently linked to the 5′ ends of the nicked DNA. In cells, TOP2ccs can be trapped by cancer drugs such as etoposide and then converted into DNA double-strand breaks (DSBs) that carry adducts at the 5′ end. The repair of such DSBs is critical to the survival of cells, but the underlying mechanism is still not well understood. We found that etoposide-induced DSBs are efficiently resected into 3′ single-stranded DNA in cells and the major nuclease for resection is the DNA2 protein. DNA substrates carrying model 5′ adducts were efficiently resected in Xenopus egg extracts and immunodepletion of Xenopus DNA2 also strongly inhibited resection. These results suggest that DNA2-mediated resection is a major mechanism for the repair of DSBs with 5′ adducts.
High-Harmonic Inverse Free-Electron-Laser Interaction at 800 NM

The inverse Free Electron Laser (IFEL) interaction has recently been proposed and used as a short wavelength modulator for micro bunching of beams for laser acceleration experiments [1,2]. These experiments utilized the fundamental of the interaction between the laser field and electron bunch. In the current experiment, we explore the higher order resonances of the IFEL interaction from a 3 period, 1.8 centimeter wavelength undulator with a picosecond, 0.5 mJ/pulse laser at 800nm. The resonances are observed by adjusting the gap of the undulator while keeping the beam energy constant. We also compare the experimental results to a simple analytic model that describes coupling to high order harmonics of the interaction.
The complete picture of the Twitter social graph

In this work, we collected the entire Twitter social graph that consists of 537 million Twitter accounts connected by 23.95 billion links, and performed a preliminary analysis of the collected data. In order to collect the social graph, we implemented a distributed crawler on the PlanetLab infrastructure that collected all information in 4 months. Our preliminary analysis already revealed some interesting properties. Whereas there are 537 million Twitter accounts, only 268 million already sent at least one tweet and no more than 54 million have been recently active. In addition, 40% of the accounts are not followed by anybody and 25% do not follow anybody. Finally, we found that the Twitter policies, but also social conventions (like the follow-back convention) have a huge impact on the structure of the Twitter social graph.
The Speed of Adjustment and the Sequencing of Economic Reforms: Issues and Guidelines for Policymakers

The automatic injection device of the invention comprises an injection syringe having a syringe body provided with a lateral injection-liquid supply tubulure, retention means for retaining the animal to be treated, enabling the latter to be placed in a given transverse position and at a given angle with respect to the syringe, syringe displacement means for advancing and withdrawing the syringe at each injection, and piston displacement means for displacing the piston with respect to the syringe body. Such a device enables for example about at least 2000 chicks to be vaccinated per hour, while at the same time ensuring a dosing accuracy on the order of 1/100 and an exact location of the point of injection.
Wireless Body Sensor Network for Continuous Cuff-less Blood Pressure Monitoring

This paper describes an unobtrusive IEEE 802.15. 4-based wireless body sensor network (BSN) that enables continuous cuff-less blood pressure monitoring, opening up new perspectives for hypertension diagnosis and treatment, cardio-vascular event detection, and stress monitoring. We estimate the arterial blood pressure based on the pulse arrival time (PAT), which is measured with a waist electrocardiogram (ECG) and an ear photo-plethysmogram (PPG). The PAT measurement requires the synchronization of the wireless sensors' clocks. This is achieved with the flooding time synchronization protocol (FTSP). The evaluation of both the implemented time synchronization and the robustness of the wireless data transmission yielded promising results. Future work will include the study of packet collisions in synchronized IEEE 802.15. 4 networks, the enhancement of the BSN with additional context-providing sensors (e.g. accelerometer, magnetometer, thermistor), and the integration of the blood pressure estimation algorithm in a wireless sensor unit.