Miracle-dz/UniFAR-FTUs huggingface dataset:
Dust scaling relations in a cosmological simulation

To study the dust evolution in the cosmological structure formation history, we perform a smoothed particle hydrodynamic simulation with a dust enrichment model in a cosmological volume. We adopt the dust evolution model that represents the grain size distribution by two sizes and takes into account stellar dust production and interstellar dust processing. We examine the dust mass function and the scaling properties of dust in terms of the characteristics of galaxies. The simulation broadly reproduces the observed dust mass functions at redshift $z = 0$, except that it overproduces the massive end at dust mass $M_\mathrm{d} \gtrsim 10^{8}$ ${\rm M}_\odot$. This overabundance is due to overproducing massive gas/metal-rich systems, but we also note that the relation between stellar mass and gas-phase metallicity is reproduced fairly well by our recipe. The relation between dust-to-gas ratio and metallicity shows a good agreement with the observed one at $z=0$, which indicates successful implementation of dust evolution in our cosmological simulation. Star formation consumes not only gas but also dust, causing a decreasing trend of the dust-to-stellar mass ratio at the high-mass end of galaxies. We also examine the redshift evolution up to $z \sim~ 5$, and find that the galaxies have on average the highest dust mass at $z = 1-2$. For the grain size distribution, we find that galaxies with metallicity $\sim 0.3~ Z_\odot$ tend to have the highest small-to-large grain abundance ratio; consequently, the extinction curves in those galaxies have the steepest ultraviolet slopes.
Consumption Upgrading and Industrial Structural Change: A General Equilibrium Analysis and Empirical Test with Low-Carbon Green Transition Constraints

To clarify the relations between low-carbon green transition, consumption upgrading, and industrial structure change, this paper firstly builds a dynamic model of the three, then uses the PVAR Model and panel data of 30 Chinese provinces from 2008 to 2020 to carry out empirical study from the rationalization and upgrading dimensions of industrial structural change, respectively. The results are as follows: (1) Low-carbon green transition and consumption upgrading are Granger causes of each other. In this causal relationship, low-carbon green transition hinders consumption upgrading, but consumption upgrading significantly promotes low-carbon green transition. (2) Low-carbon green transition plays a facilitating and hindering role in industrial structure rationalization and upgrading, respectively. However, from the different dimensions of industrial structure change, only industrial structure upgrading has a significant reverse hindering effect on low-carbon green transition, and the reverse effect of industrial structure rationalization on low-carbon green transition is not significant. (3) Consumption upgrading has a hindering and promoting effect on the rationalization of industrial structure in the short- and long-run respectively, and a promoting and hindering effect on the industrial structure upgrading respectively; however, only industrial structure upgrading significantly promotes consumption upgrading in the opposite direction, while industrial structure rationalization has no significant effect on consumption upgrading. These findings propose some suggestions such as advocating the new way of green consumption, constructing and improving the green whole industry chain, and strengthening the synergy between imitative innovation and independent innovation.
Synthesis of a New Glycoconjugate with Di-ᴅ-Psicose Anhydride Structure

Demand for healthy diets has led researchers to explore new saccharide as sucrose alternatives. ᴅ-Psicose, the C-3 epimer of ᴅ-fructose, has a similar sweetness intensity to sucrose but contributes fewer calories. This study proposes a disaccharide with a stable structure derived from ᴅ-psicose. The compound with a spiro-tricyclic core was generated at 32% conversion via caramelization of ᴅ-psicose under acidic anhydrous conditions. The compound was identified by high-resolution mass spectrometry and multi-dimensional nuclear magnetic resonance (NMR). The molecular formula was established as C12H20O10 from the molecular weight of m/z 324.1055. Twelve signals were observed by the 13C NMR spectrum. This compound, denoted di-ᴅ-psicose anhydride (DPA), exhibited a lower water solubility (40 g/L) and higher thermal stability (peak temperature = 194.7 °C) than that of ᴅ-psicose (peak temperature = 126.5 °C). The quantitatively evaluated metal ion scavenging ability of DPA was the best in magnesium (average 98.6 ± 1.1%). This synthesis methodology can provide disaccharides with high stability-reducing heavy metals.
Genome‐wide association study and genomic prediction for intramuscular fat content in Suhuai pigs using imputed whole‐genome sequencing data

Integrating the single‐nucleotide polymorphisms (SNPs) significantly affecting target traits from imputed whole‐genome sequencing (iWGS) data into the genomic prediction (GP) model is an economic, efficient, and feasible strategy to improve prediction accuracy. The objective was to dissect the genetic architecture of intramuscular fat content (IFC) by genome wide association studies (GWAS) and to investigate the accuracy of GP based on pedigree‐based BLUP (PBLUP) model, genomic best linear unbiased prediction (GBLUP) models and Bayesian mixture (BayesMix) models under different strategies. A total of 482 Suhuai pigs were genotyped using an 80 K SNP chip. Furthermore, 30 key samples were selected for resequencing and were used as a reference panel to impute the 80 K chip data to the WGS dataset. The 80 K data and iWGS data were used to perform GWAS and test GP accuracies under different scenarios. GWAS results revealed that there were four major regions affecting IFC. Two important functional candidate genes were found in the two most significant regions, including protein kinase C epsilon (PRKCE) and myosin light chain 2 (MYL2). The results of the predictions showed that the PBLUP model had the lowest reliability (0.096 ± 0.032). The reliability (0.229 ± 0.035) was improved by replacing pedigree information with 80 K chip data. Compared with using 80 K SNPs alone, pruning iWGS SNPs with the R‐squared cutoff of linkage disequilibrium (0.55) led to a slight improvement (0.006), adding significant iWGS SNPs led to an improvement of reliability by 0.050 when using a one‐component GBLUP, a further increase of 0.033 when using a two‐component GBLUP model. For BayesMix models, compared with using 80 K SNPs alone, adding additional significant iWGS SNPs into one‐ or two‐component BayesMix models led to improvements of reliabilities for IFC by 0.040 and 0.089, respectively. Our results may facilitate further identification of causal genes for IFC and may be beneficial for the improvement of IFC in pig breeding programs.
Horizontal-Branch Morphology and Dense Environments: Hubble Space Telescope Observations of Globular Clusters NGC 2298, 5897, 6535, and 6626

HST observations of the core of four galactic globular clusters allowed us to obtain interesting clues about the influence of the environment on the star distribution along the horizontal branch. The chemical composition and the age of the target clusters have been derived through a detailed analysis of the (V, V-I) color-magnitude diagrams. The photometric metallicities have been found in close agreement with the recent spectroscopic determinations. The four clusters are coeval within the uncertainties. Hence, age and metallicity cannot account for the difference in the horizontal-branch morphologies, as shown by a comparison with theoretical zero-age horizontal-branch sequences and synthetic horizontal branches taken from the literature. Our analysis further supports the hypothesis according to which dense environments cause the occurrence of the so-called "blue tails" in the horizontal branches of galactic globular clusters. The use of HST, as well as of ground-based data for some clusters, enabled us to study the radial distribution of the various evolved populations, starting from the very center. We thus discovered that blue stragglers are, in general, more concentrated while the horizontal and the red giant branch do not display a markedly different trend with the distance from the cluster center, although the red giant branch of NGC 6626 is more concentrated than the horizontal branch.
The Effect of Stabilized Rice Bran Addition on Physicochemical, Sensory, and Techno-Functional Properties of Bread

Rice bran (RB) is a valuable byproduct derived from rice milling that represents an excellent opportunity for dietary inclusion. Bioactive components with antioxidant potential have been reported in RB, gaining the considerable attention of researchers. However, RB requires a stabilization process after milling to prevent it from becoming rancid and promote its commercial consumption. The aim of this study was to evaluate the effects of substituting stabilized rice bran (SRB) for wheat flour at levels of 10, 15, 20 and 25% on the proximate composition, dietary fiber, dough rheology, antioxidant properties, content of bioactive compounds, and sensory attributes of white wheat-based bread. Results indicated that the incorporation of SRB increased the bread’s insoluble dietary fiber, phytic acid, total polyphenol content, γ-oryzanol, γ-aminobutyric acid, and antioxidant properties, while decreased its water absorption capacity, elasticity, volume, β-glucans, and soluble dietary fiber content. Moreover, substituting wheat flour for SRB at levels higher than 15% affected sensory attributes, such as color, odor, flavor, and softness. This study highlights the potential application of SRB flour in bread-making to increase nutritional, and functional properties of white wheat bread.
Sensitivity study for the $^{12}$C($\alpha,\gamma$)$^{16}$O astrophysical reaction rate

The $^{12}$C($\alpha,\gamma$)$^{16}$O reaction has a key role in nuclear astrophysics. A multilevel R-matrix analysis was used to make extrapolations of the astrophysical S factor for this reaction to the stellar energy of 300 keV. The statistical precision of the S-factor extrapolation was determined by performing multiple fits to existing randomized E1 and E2 ground state data, according to experimental errors. The impact of a future proposed experiment at Jefferson Laboratory (JLab) was assessed within this framework. The proposed JLab experiment will make use of a high-intensity low-energy bremsstrahlung beam that impinges on an oxygen-rich single-fluid bubble chamber in order to measure the total cross section for the inverse $^{16}$O($\gamma,\alpha$)$^{12}$C reaction. The importance of low energy data as well as high precision data was investigated.
Amino Acid Solutions for 177Lu-Oxodotreotide Premedication: A Tolerance Study

Simple Summary [177Lu]oxodotreotide (Lutathera®) was approved by the European Medical Agency in 2017 and the Food and Drug Administration in 2018 for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors as the first radiopharmaceutical for peptide receptor radionuclide therapy (PRRT). PRRT premedication using an amino acid solution is the standard regimen for renal protection. In this way, our nuclear medicine department used two types of amino acid perfusion. Firstly, a commercial solution containing a mixture of amino acids and, next, a lysine–arginine preparation. We aimed to estimate the tolerance profile and risk factors of adverse events with both solutions. In our large cohort of patients (76 patients for 236 cycles), we confirmed the better tolerance of the lysine–arginine preparation. The risk factors identified were being of the female sex and the use of the commercial solution. To our knowledge, this is the first study to evaluate the tolerance of amino acid solutions with real-life patient data in a large cohort. Abstract Background: The co-infusion of amino acid solutions during peptide receptor radionuclide therapy reduces the tubular reabsorption of 177Lu-oxodotreotide, thus minimizing nephrotoxicity. In our nuclear medicine department, the patients received two different types of amino acid perfusion over time: a commercial solution (CS) containing 10% amino acids, and a 2.5% lysine–arginine (LysArg) hospital preparation, produced by a referral laboratory. The aim of the present study was to analyze the tolerance of the two amino acid solutions. Methods: The patient files were analyzed and double-checked. The study parameters comprised the gender, age, primary tumor site, type of amino acid perfusion, adverse events (AE) and WHO AE grades, antiemetic premedication, creatinine, and serum potassium level. Results: From February 2016 to February 2019, 76 patients were treated, for a total 235 cycles. AEs occurred in 71% of the CS cycles (n = 82/116), versus 18% (n = 21/119) in the LysArg group (p < 0.0001). In the CS group, the AEs were mostly WHO grade 4 (n = 24/82), and mostly grade 1 in the LysArg group (n = 13/21). Poisson regression showed a higher risk of AE overall and of grades 3 and 4 in the females and with CS. The mean creatinine clearance was identical before and after the PRRT cycles, whichever amino acid perfusion was used. Conclusions: The lysine–arginine preparation showed better tolerance than the commercial solution. The change to LysArg reduced the antiemetic premedication from four molecules to one.
Network Pharmacology Analysis and Experimental Validation of Kaempferol in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Neuroinflammation Involving Neutrophils

Kaempferol, a natural plant flavonoid compound, has a neuroprotective effect on ischemic stroke, while the specific mechanism remains unclear. In the current study, we applied the comprehensive strategy that combines network pharmacology and experimental evaluation to explore the potential mechanism of kaempferol in the treatment of cerebral ischemia. First, network pharmacology analysis identified the biological process of kaempferol, suggesting that kaempferol may partly help in treating ischemic stroke by regulating apoptosis and inflammatory response. Then, we evaluated the efficacy of kaempferol in the acute stage of ischemic stroke and elucidated its effects and possible mechanisms on cell apoptosis and neuroinflammation involved by neutrophils. The results showed that kaempferol could significantly reduce the modified neurological severity score (mNSS), and reduce the volume of cerebral infarction and the degree of cerebral edema. In terms of anti-apoptosis, kaempferol could significantly reduce the number of TUNEL-positive cells, inhibit the expression of pro-apoptotic proteins and promote the expression of anti-apoptotic proteins. Kaempferol may play an anti-apoptotic role by up-regulating the expression level of the BDNF-TrkB-PI3K/AKT signaling pathway. In addition, we found that kaempferol inhibited neuron loss and the activation of glial cells, as well as the expression level of the inflammatory protein COX-2 and the classic pro-inflammatory signaling pathway TLR4/MyD88/NF-κB in the ischemic brain, reduced MPO activity and neutrophil counts in peripheral blood, and down-regulated neutrophil aggregation and infiltration in the ischemic brain. Western blot revealed that kaempferol down-regulated the activation of the JAK1/STAT3 signaling pathway in neutrophils and ischemic brains. Our study showed that kaempferol inhibited the activation and number of neutrophils in the rat peripheral blood and brain, which may be related to the down-regulation of the JAK1/STAT3 pathway.
Viscosity, surface tension and refractive index of tetraethylorthosilicate-based sol-gel materials depending on ethanol content

The sol-gel-derived materials can be exploited for the number of applications, including biomaterials and measuring techniques. One of the most important applications involves production of sol-gel coatings. In this study, silica based sol-gel materials were prepared by way of acid hydrolysis with alcohol as a solvent. Tetraethylorthosilicate (TEOS) was used as a precursor. Different samples were tested; with molar ratios R = 5, 10, 15, 20, 32 and 50, denoting the number of ethanol moles to the number of TEOS moles. The viscosity and surface tension of liquid hydrolizates were measured depending on the ethanol content in sol-gel. The thickness of a coating layer was determined, as well. The refractive index was measured 10 days long, up to the point of gelation. It was demonstrated that viscosity, surface tension and refractive index are lower for higher R value (for higher alcohol content), whereas the sol-gel layers produced with higher R values are thicker than these ones produced with lower alcohol content. It is also demonstrated that R value influences the performance of fiberoptic sol-gel applicators for interstitial laser therapy.
Psychometric properties of the Bergen Work Addiction Scale in a Greek sample of health professionals

BACKGROUND Work addiction it is an emerging topic in organizational research because it has a great impact on human resources, especially in the health sector, and has led to the development of a number of valid assessment tools. Among work addiction scales, the Bergen Work Addiction Scale (BWAS) has good psychometric properties and a small number of items, and comes with a recommended cut-off for categorization of work addiction. The aim of the present study was to evaluate the psychometric properties of the BWAS in a Greek sample of health professionals (HPs) and to measure their work addiction. PARTICIPANTS AND PROCEDURE A cross sectional study using an online questionnaire related to work addiction was completed by 542 HPs through the official websites of 8 secondary hospitals in Greece. RESULTS The level of HPs’ work addiction was moderate. The internal structure of the scale was satisfactory (α = .78). All seven items of the BWAS were significant and had standardized values above 0.48. Work addiction was significantly associated with older age and the profession of physician. CONCLUSIONS Based on the findings of the present study, the Greek BWAS has good psychometric properties, such as good reliability, internal consistency and construct validity and is recommended as a suitable tool to assess work addiction in clinical settings and future research.
Chandra Observations of the Field Containing HESS J1616–508

We report the results of three Chandra observations covering most of the extent of the TeV γ-ray source HESS J1616–508 and a search for a lower-energy counterpart to this source. We detect 56 X-ray sources, 37 of which have counterparts at lower frequencies, including a young massive star cluster, but none of them appear to be a particularly promising counterpart to the TeV source. The brightest X-ray source, CXOU J161423.4–505738, with a flux F0.5–7 keV ≈ 5 × 10−13 erg cm−2 s−1, has a hard spectrum that is well fit by a power-law model with a photon index Γ = 0.2 ± 0.3 and is a likely intermediate polar CV candidate. No counterparts of this source were detected at other wavelengths. CVs are not known to produce extended TeV emission, and the source is also largely offset (19′) from HESS J1616–508, making them unlikely to be associated. We have also set an upper limit on the X-ray flux of PSR J1614–5048 in the 0.5–8 keV band (F0.5–8 keV < 5 × 10−15 erg cm−2 s−1 at a 90% confidence level). This makes PSR J1614–5048 one of the least X-ray-efficient pulsars known, with an X-ray efficiency . We find no evidence supporting the association between the pulsar and the TeV source. We rule out a number of X-ray sources as possible counterparts to the TeV emission and do not find a plausible counterpart among the other sources. Lastly, we discuss the possible relation of PSR J1617–5055 to HESS J1616–508 in light of the new observations.
Atomic-scale interface engineering of Majorana edge modes in a 2D magnet-superconductor hybrid system

Interface engineering of the Fe/Re hybrid system leads to a topological superconducting state with chiral Majorana edge modes. Topological superconductors are predicted to harbor exotic boundary states—Majorana zero-energy modes—whose non-Abelian braiding statistics present a new paradigm for the realization of topological quantum computing. Using low-temperature scanning tunneling spectroscopy, here, we report on the direct real-space visualization of chiral Majorana edge states in a monolayer topological superconductor, a prototypical magnet-superconductor hybrid system composed of nanoscale Fe islands of monoatomic height on a Re(0001)-O(2 × 1) surface. In particular, we demonstrate that interface engineering by an atomically thin oxide layer is crucial for driving the hybrid system into a topologically nontrivial state as confirmed by theoretical calculations of the topological invariant, the Chern number.
Anisotropic Tensile Properties in Ni-Based Single-Crystal Superalloy DD6 near [001] Orientation at 760°C

This work is concerned the tensile properties of the secondary Ni-based single-crystal superalloy DD6 near [001] orientation at 760°C. In this study, anisotropic tensile properties of DD6 alloy within 10° of the [001] orientation were exhibited at 760°C. The yield strength and ultimate tensile strength of DD6 alloy oriented close to [001] direction was the highest. As the deviation off the [001] orientation increased, both 0.2% yield strength and ultimate tensile strength was decreased. The specimens oriented close to [001]-[111] boundary exhibit higher yield strength and ultimate tensile strength than the specimens oriented close to [001]-[011] boundary. Numerous of dislocations can be found in the γ matrix channels during the tensile deformation. A number of dislocation pairs and few of stacking faults are found in the γ' precipitates after the tensile at 760°C. The morphology of γ' phases in DD6 alloy maintained cubical during the tensile deformation at 760°C. With Schmid's Law, the mechanism of anisotropic tensile properties in DD6 alloy near [001] orientation is analyzed.
Direct Observations of Different Sunspot Waves Influenced by Umbral Flashes

We report the simultaneous presence of chromospheric umbral flashes and associated umbral waves, and propagating coronal disturbances, in a sunspot and related active region. We have analyzed time–distance maps obtained using the observations from the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory. These maps show the simultaneous occurrence of different sunspot oscillations and waves such as umbral flashes, umbral waves, and coronal waves. Analysis of the original light curves, i.e., without implementing any Fourier filtering on them, shows that the amplitudes of different sunspot waves observed at different atmospheric layers change in synchronization with the light curves obtained from the umbral flash region, thus demonstrating that these oscillations are modulated by umbral flashes. This study provides the first observational evidence of the influence of sunspot oscillations within the umbra on other sunspot waves extending up to the corona. The properties of these waves and oscillations can be utilized to study the inherent magnetic coupling among different layers of the solar atmosphere above sunspots.