Miracle-dz/UniFAR-FTUs huggingface dataset:
SERUM MAGNESIUM LEVEL IN FEBRILE CONVULSION

Mean age of cases with febrile convulsion and febrile patients without seizures were 1.97years (+/-) 1.33years and 2.01years (+ /-)1.02 years respectively. there were 24 male and 21 female babies in group 1 and 23 male and 22 females in other group. the mean age and sex were similar in both groups. Mean level of magnesium were 1.97+_0. 24 and 2.19 +_ 0.20 in cases with febrile convulsion and febrile patients without seizures respectively and there was significant differences.
Cryoanesthesia as a Supplementary Aid to the Mandibular Anesthetic Technique in Endodontics: A Preliminary Experience

Objective: Describe the cryoanesthetic effect of the use of dry ice (solid Carbon Dioxide) spray in patients with Irreversible Pulpitis (IP) undergoing conventional endodontic treatment in lower molars. Materials and Methods: This are an-in vivo quasi-experimental study with a convenience sample of 126 patients who met the criteria for selection. The clinical history was completed, obtaining socio-demographic characteristics, including the diagnosis of IP. After previously signing informed consent, patients were anesthetized applying the inferior alveolar anesthetic technique; after a period of five minutes, molars were completely isolated, then dry ice spray was applied for two seconds. Subsequently, a conventional access cavity was opened, applying intrapulpal anesthesia upon pulp exposure. For the purpose of measuring the pain experienced by the patients during access cavity opening and instrumentation procedures, the Heft-Parker modified visual analog scale (HPVAS) was used. Results: 60% of the subjects (sample) were female, the average age range was between 53 and 63 years. The tooth most frequently affected by IP was 46. According to HPVAS, 94.4% of patients reported feeling no pain, gender had no influence on the outcome of HPVAS. Based on the odds ratio related to Chi2 at older age, there is a 1.6% probability of success per year. Age showed a P value of less than 0.05. The relation between gender and the affected tooth did not show a statistically significant difference. Conclusion: Cryoanesthesia was successful as a supplementary aid to mandibular anesthesia in the endodontic treatment of lower molars.
Modified Simulation Learning Method on Knowledge and Attitude of Nursing Student's Cultural Awareness at Universitas Indonesia

Nursing students should be prepared to be culturally competent nurses. Cultural awareness is believed as the most important elements of cultural competence. The purpose of this article is to describe the effectiveness of Modified Simulation Learning Methods on cultural awareness as one atribute of cultural competence. A quasi-experimental (control group) design was used to explore the relationship between variabels among 98 first year nursing student attending Basic Nursing Concept I course at Faculty of Nursing Universitas Indonesia. The knowledge of cultural awareness was found statistically different between participants in Modified Simulation Methods group (intervention) and participants using the regular method. However, there were no statistical differences in attitude of cultural awareness between intervention and control groups. It could be concluded that Modified Simulation Learning methods is an effective learning method for increasing cultural knowledge of nusing student to be a competent nurse. Further research should be developed in continuing the improvement of cultural competence such as cultural skills.
Comparison of the Clinical Effectiveness of Single Versus Multiple Injections of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis

Background: Reports have concluded that platelet-rich plasma (PRP) is an effective and safe biological approach in the treatment of knee osteoarthritis (OA). However, no consensus has been established regarding the number of injections required to observe a therapeutic effect. Purpose: To compare the clinical effectiveness reported in randomized controlled trials (RCTs) of single versus multiple PRP injections in the treatment of knee OA. Study Design: Systematic review; Level of evidence, 1. Methods: A comprehensive search was conducted for RCTs published between 1970 and 2019 that compared the effect of single versus multiple PRP injections on pain and functionality in patients with knee OA. Searched databases included MEDLINE, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials. A data extraction form was designed to obtain bibliographic information of the study as well as patient, intervention, comparison, and outcomes of interest data. A random-effects model was used to pool quantitative data from the primary outcomes. Results: We included 5 clinical trials with a low-moderate risk of bias that reported data for 301 patients. Meta-analysis showed that, at 6 months after the intervention, single and multiple (double or triple) injections had similar pain improvement, with no significant differences (standardized mean difference [SMD], 0.61 [95% CI, −1.09 to 2.31]; I 2 = 97%; P = .48). A significant improvement in knee functionality was observed in favor of multiple injections (SMD, 2.29 [95% CI, 0.45-4.12]; I 2 = 97%; P = .01). Subanalysis showed that the significant improvement was only evident for the results of single versus triple injections (SMD, 3.12 [95% CI, 0.64-5.60]; I 2 = 97%; P = .01). Conclusion: According to our results, a single injection was as effective as multiple PRP injections in pain improvement; however, multiple injections seemed more effective in joint functionality than a single injection at 6 months. We consider that the available evidence is still insufficient, and future research on this specific topic is needed to confirm our results.
Potential mechanism of ferroptosis in pancreatic cancer

Despite the incidence rates of pancreatic cancer being low worldwide, the mortality rates remain high. To date, there is no effective drug treatment for pancreatic cancer. Numerous signalling pathways and cytokines regulate the occurrence and development of pancreatic cancer. Ferroptosis is a non-traditional form of cell death resulting from iron-dependent lipid peroxide accumulation. Studies have demonstrated that ferroptosis is associated with a variety of different types of cancer, such as breast cancer, hepatocellular carcinoma and pancreatic cancer. The present study demonstrated that ferroptosis controls the growth and proliferation of pancreatic cancer, providing a new approach for the treatment of pancreatic cancer. Iron metabolism and reactive oxygen species metabolism are the key pathways involved in ferroptosis in pancreatic cancer. In addition, a number of regulators of ferroptosis, such as glutathione peroxidase 4 and the cystine/glutamate antiporter system Xc-, also play pivotal roles in the regulation of ferroptosis. In the present review, the regulatory mechanisms associated with ferroptosis in pancreatic cancer are summarized, alongside other associated forms of digestive system cancer. The treatment of ferroptosis-based diseases is also addressed.
Decreased expression of TXNIP predicts poor prognosis in patients with clear cell renal cell carcinoma

Accumulating evidence has demonstrated that thioredoxin interacting protein (TXNIP) is abnormally expressed in a variety of malignant tumors and functions as a tumor suppressor. However, the association between TXNIP and clear cell renal cell carcinoma (CCRCC) has not yet been fully elucidated. The aim of the present study was to evaluate the role of TXNIP in CCRCC using The Cancer Genome Atlas (TCGA) database. The RNA sequencing data and corresponding clinical data were collected from TCGA database. The association between TXNIP and patient clinicopathological characteristics was analyzed using analysis of variance and logistic regression. The Kaplan-Meier method and Cox proportional hazards model were used to assess the association between TXNIP and overall survival. Gene Set Enrichment Analysis (GSEA) was used to explore the associated signaling pathways. TXNIP expression was identified to be decreased in CCRCC tissues compared with normal tissues. The decreased expression of TXNIP in CCRCC was significantly associated with clinical stage [OR=0.509 for III vs. I (P=0.002); OR=0.527 for IV vs. I (P=0.012)], T stage [OR=0.552 for T3 vs. T1 (P=0.002)] and grade [OR=0.261 for G4 vs. G1 (P=0.027)]. Kaplan-Meier survival analysis indicated that cases of CCRCC with low TXNIP expression were associated with poorer prognoses compared with those with a high expression level (P=0.002). Univariate and multivariate Cox analyses indicated that TXNIP was an independent prognostic factor in CCRCC. GSEA revealed that 6 pathways exhibited significant differential enrichment in the TXNIP high-expression phenotype, including the WNT signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, the phosphatidylinositol signaling system, the transforming growth factor-β (TGF-β) signaling pathway, autophagy and the Janus kinase (JAK)-STAT signaling pathway. Taken together, the results of the present study indicate that TXNIP expression may be a potential prognostic marker for patients with CCRCC. In addition, the WNT signaling pathway, MAPK signaling pathway, phosphatidylinositol signaling system, TGF-β signaling pathway, autophagy and the JAK-STAT signaling pathway may be the crucial pathways regulated by TXNIP in CCRCC.
Short- and long-term effects of lipopolysaccharide-induced endotoxemia on mice ovarian tissue: histomorphometrical evaluation

Endotoxemia is an acute systemic reaction of the body caused by the presence of endotoxins such as bacterial lipopolysaccharide in the blood, which is associated with clinical signs. Lipopolysaccharide is a part of the outer membrane of the cell wall of gram-negative bacteria. The aim of the present study was to determine the effect of E-coli lipopolysaccharide administration on histomorphometric changes in mice ovarian tissue. Adult female mice were randomly divided into the control and treatment groups, with ten mice in each. The treatment group received 6750 μg/kg of lipopolysaccharide intraperitoneally and in the control group, normal saline was injected at the same dosage. Five mice from each experimental group were euthanized on days 3 & 30 after the beginning of the treatment, then the right ovary was removed, fixed and serially sectioned for histomorphometric evaluation. The results obtained showed that 3 days after lipopolysaccharide injection the estimated ovarian parameters, including primary follicles, secondary follicles and corpora lutea, had decreased significantly (P≤0.05). The mean number of antral follicles was not influenced by lipopolysaccharide injection on days 3 and 30. The mean number of primary follicles on day 30 (53.4 ± 4.6) showed a significant increase in comparison with the treatment group on day 3 (42.1 ± 4.1) which was close to its values in the control group. The mean number of secondary follicles and corpora lutea on day 30 (36 ± 4.8 and 34.2 ± 10.8, respectively) showed a relative improvement, however it was still lower than the control group counterparts (49.5 ± 5.0 and 39.2 ± 3.9, respectively). According to our results, endotoxemia induced by lipopolysaccharide has short-time deleterious effects on ovarian follicles but they recovered somewhat after a short time equal to a folliculogenesis cycle, from primordial follicle to preovulatory antral follicle.
Number : PLA-D18-01785 R 1 Title : Dynamics of conservative peakons in a system of Popowicz Article Type : Letter Section / Category : Mathematical physics

We consider a two-component Hamiltonian system of partial differential equations with quadratic nonlinearities introduced by Popowicz, which has the form of a coupling between the Camassa-Holm and Degasperis-Procesi equations. Despite having reductions to these two integrable partial differential equations, the Popowicz system itself is not integrable. Nevertheless, as one of the authors showed with Irle, it admits distributional solutions of peaked soliton (peakon) type, with the dynamics of N peakons being determined by a Hamiltonian system on a phase space of dimension 3N . As well as the trivial case of a single peakon (N = 1), the case N = 2 is Liouville integrable. We present the explicit solution for the two-peakon dynamics, and describe some of the novel features of the interaction of peakons in the Popowicz system.
Breeding bird species diversity across gradients of land use from forest to 14 agriculture in Europe 15 16

48 Loss, fragmentation and decreasing quality of habitats have been proposed as major threats to 49 biodiversity world-wide, but relatively little is known about biodiversity responses to multiple 50 pressures, particularly at very large spatial scales. We evaluated the relative contributions of 51 four landscape variables (habitat cover, diversity, fragmentation and productivity) in 52 determining different components of avian diversity across Europe. We sampled breeding birds 53 in multiple 1-km landscapes, from high forest cover to intensive agricultural land, in eight 54 countries during 2001−02. We predicted that the total diversity would peak at intermediate 55 levels of forest cover and fragmentation, and respond positively to increasing habitat diversity 56 and productivity; forest and open-habitat specialists would show threshold conditions along 57 gradients of forest cover and fragmentation, and respond positively to increasing habitat 58 diversity and productivity; resident species would be more strongly impacted by forest cover 59 and fragmentation than migratory species; and generalists and urban species would show weak 60 responses. Measures of total diversity did not peak at intermediate levels of forest cover or 61 fragmentation. Rarefaction-standardized species richness decreased marginally and linearly 62 with increasing forest cover and increased non-linearly with productivity, whereas all measures 63 increased linearly with increasing fragmentation and landscape diversity. Forest and open64 habitat specialists responded approximately linearly to forest cover and also weakly to habitat 65 diversity, fragmentation and productivity. Generalists and urban species responded weakly to 66 the landscape variables, but some groups responded non-linearly to productivity and marginally 67 to habitat diversity. Resident species were not consistently more sensitive than migratory 68 species to any of the landscape variables. These findings are relevant to landscapes with 69 relatively long histories of human land-use, and they highlight that habitat loss, fragmentation 70 and habitat-type diversity must all be considered in land-use planning and landscape modeling 71 of avian communities. 72
A PROGRAM TO PREVENT FUNCTIONAL DECLINE IN PHYSICALLY FRAIL, ELDERLY PERSONS WHO LIVE AT HOME

A BSTRACT Background Functional decline in physically frail, elderly persons is associated with substantial morbidity. It is uncertain whether such functional decline can be prevented. Methods We randomly assigned 188 persons 75 years of age or older who were physically frail and living at home to undergo a six-month, home-based intervention program that included physical therapy and that focused primarily on improving underlying impairments in physical abilities, including balance, muscle strength, ability to transfer from one position to another, and mobility, or to undergo an educational program (as a control). The primary outcome was the change between base line and 3, 7, and 12 months in the score on a disability scale based on eight activities of daily living: walking, bathing, upperand lowerbody dressing, transferring from a chair, using the toilet, eating, and grooming. Scores on the scale ranged from 0 to 16, with higher scores indicating more severe disability. Results Participants in the intervention group had less functional decline over time, according to their disability scores, than participants in the control group. The disability scores in the intervention and control groups were 2.3 and 2.8, respectively, at base line; 2.0 and 3.6 at 7 months (P=0.008 for the comparison between the groups in the change from base line); and 2.7 and 4.2 at 12 months (P=0.02). The benefit of the intervention was observed among participants with moderate frailty but not those with severe frailty. The frequency of admission to a nursing home did not differ significantly between the intervention group and the control group (14 percent and 19 percent, respectively; P=0.37). Conclusions A home-based program targeting underlying impairments in physical abilities can reduce the progression of functional decline among physically frail, elderly persons who live at home. (N Engl J Med 2002;347:1068-74.)
Preseason Injury Characteristics in Spanish Professional Futsal Players: The LNFS Project

Abstract López-Segovia, M, Vivo Fernández, I, Herrero Carrasco, R, and Pareja Blanco, F. Preseason injury characteristics in Spanish professional futsal players: the National Futsal League (LFNS) project. J Strength Cond Res 36(1): 232–237, 2022—This study aimed to examine the incidence of injuries and their characteristics among professional Spanish futsal players during the preseason period and to compare injury-related variables in the context of both competition and training. Eleven futsal teams belonging to the First and Second Spanish Division and 161 players participated in the study. Characteristics of injuries, including type, location, cause and time of injury, injury recurrence, and duration of absence, were recorded. A total of 62 injuries were reported; injury rates of 9.9 (95% confidence interval [CI]: 7.0–12.5) injuries/1,000 training hours and 61.1 (95% CI: 25.7–96.5) injuries/1,000 match hours were collected. These data indicate a mean of 5.64 ± 2.66 injuries per team during the preseason period. Of these injuries, 92.1% involved the lower limbs. When data from training and competition were analyzed together, the highest incidence of injuries affected the ankle (21%), followed by the hip/groin and knee (19.4% each). The most common type of injury was muscle rupture/tear/strain (29.0%). During training, the highest percentage of injuries were located in the knee (23.9%), followed by the ankle and hip/groin (21.7% in each case), while during matches, the thigh (35.7%) followed by the ankle (21.4%) was the regions most affected. A significant relationship (p = 0.008) was observed between injury cause (without contact, with other player, with the ball, and others) and injury context (training, match). To conclude, the results of this study suggest the need for injury prevention protocols focuses on the ankle and the knee joints and muscle strain prevention.
Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group

With the development of modern solid-phase assays to detect anti-HLA antibodies and a more precise histological classification, the diagnosis of antibody-mediated rejection (AMR) has become more common and is a major cause of kidney graft loss. Currently, there are no approved therapies and treatment guidelines are based on low-level evidence. The number of prospective randomized trials for the treatment of AMR is small, and the lack of an accepted common standard for care has been an impediment to the development of new therapies. To help alleviate this, The Transplantation Society convened a meeting of international experts to develop a consensus as to what is appropriate treatment for active and chronic active AMR. The aim was to reach a consensus for standard of care treatment against which new therapies could be evaluated. At the meeting, the underlying biology of AMR, the criteria for diagnosis, the clinical phenotypes, and outcomes were discussed. The evidence for different treatments was reviewed, and a consensus for what is acceptable standard of care for the treatment of active and chronic active AMR was presented. While it was agreed that the aims of treatment are to preserve renal function, reduce histological injury, and reduce the titer of donor-specific antibody, there was no conclusive evidence to support any specific therapy. As a result, the treatment recommendations are largely based on expert opinion. It is acknowledged that properly conducted and powered clinical trials of biologically plausible agents are urgently needed to improve patient outcomes.
Helminth infections drive heterogeneity in human type 2 and regulatory cells

Mass cytometry identifies clusters of type 2 and regulatory immune responses in pre– and post–anthelmintic treatment human blood samples. Parasite perturbation of immunity Helminths infect billions of people and are known to modulate host immune responses to promote their survival. De Ruiter et al. used mass cytometry to gain a better understanding of which cells are affected by helminth infection. They analyzed samples from rural Indonesians before and after deworming treatment. These were compared to samples from Europeans and urban Indonesians, neither of which had been exposed to helminths. Helminths expanded specific type 2 and regulatory cells; many immune alterations reverted upon deworming. These details on host-pathogen interaction could inform future targeted therapies. Helminth infections induce strong type 2 and regulatory responses, but the degree of heterogeneity of such cells is not well characterized. Using mass cytometry, we profiled these cells in Europeans and Indonesians not exposed to helminths and in Indonesians residing in rural areas infected with soil-transmitted helminths. To assign immune alteration to helminth infection, the profiling was performed before and 1 year after deworming. Very distinct signatures were found in Europeans and Indonesians, showing expanded frequencies of T helper 2 cells, particularly CD161+ cells and ILC2s in helminth-infected Indonesians, which was confirmed functionally through analysis of cytokine-producing cells. Besides ILC2s and CD4+ T cells, CD8+ T cells and γδ T cells in Indonesians produced type 2 cytokines. Regulatory T cells were also expanded in Indonesians, but only those expressing CTLA-4, and some coexpressed CD38, HLA-DR, ICOS, or CD161. CD11c+ B cells were found to be the main IL-10 producers among B cells in Indonesians, a subset that was almost absent in Europeans. A number of the distinct immune profiles were driven by helminths as the profiles reverted after clearance of helminth infections. Moreover, Indonesians with no helminth infections residing in an urban area showed immune profiles that resembled Europeans rather than rural Indonesians, which excludes a major role for ethnicity. Detailed insight into the human type 2 and regulatory networks could provide opportunities to target these cells for more precise interventions.
Mild cognitive impairment, psychiatric symptoms, and executive functioning in patients with Parkinson's disease

Mild cognitive impairment (MCI) and psychiatric symptoms (anxiety, depression, and apathy) are common in Parkinson's disease (PD). While studies have supported the association between psychiatric symptoms and cognitive performance in PD, it is unclear if the magnitude of link between psychiatric symptoms and cognitive health is stronger by MCI status. The purpose of this study was to examine the association between cognitive performance and psychiatric symptoms in PD and whether MCI status moderates this association.