Miracle-dz/UniFAR-FTUs huggingface dataset:
Protective Effects of Alpha-Lipoic Acid against 5-Fluorouracil-Induced Gastrointestinal Mucositis in Rats

Alpha-lipoic acid (ALA) is extensively utilized in multivitamin formulas and anti-aging products. The purpose of this study was to investigate the potential protective benefits of ALA on 5-fluorouracil (5-FU)-induced gastrointestinal mucositis in Wistar albino rats. Tissues from the stomach, small intestine, and large intestine were excised, and blood sera were obtained to identify biochemical indices such as TNF-α, IL-1β, MDA, GPx, SOD, MMP-1, -2, -8, and TIMP-1. A histopathological study was also performed. The results revealed mucositis-elevated TNF-, IL-1, MDA, MMP-1, -2, -8, and TIMP-1 levels in both tissues and sera, and these values dropped dramatically following ALA treatment. Reduced SOD and GPx activities in mucositis groups were reversed in ALA-treated groups. The damage produced by mucositis in the stomach and small intestine regressed in the ALA-treated group, according to histopathological evaluation. Consequently, the implementation of ALA supplementation in 5-FU therapy may act as a protective intervention for cancer patients with gastrointestinal mucositis. In light of the findings, ALA, a food-derived antioxidant with pleiotropic properties, may be an effective treatment for 5-FU-induced gastrointestinal mucositus, and prevent oxidative stress, inflammation, and tissue damage in cancer patients receiving 5-FU therapy.
High-resolution Very Large Array observations of 18 MIPSGAL bubbles

We present radio observations of 18 MIPSGAL bubbles performed at 5 GHz (6 cm) with the Karl G. Jansky Very Large Array in configuration B and BnA. The observations were aimed at understanding what kind of information high-resolution and high-sensitivity radio maps can supply on the circumstellar envelopes of different kinds of evolved stars and what their comparison with infrared images with similar resolution can tell us. We found that the 18 bubbles can be grouped into five categories according to their radio morphology. The three bubbles presenting a central point source in the radio images all correspond to luminous blue variable star candidates. Eleven bubbles show an elliptical shape and the total lack of a central object in the radio, and are likely associated with planetary nebulae. Under this assumption we derive their distance, their ionized mass and their distribution on the Galactic plane. We discuss the possibility that the MIPSGAL bubbles catalogue (428 objects) may contain a large fraction of all Galactic planetary nebulae located at a distance between 1.4 kpc and 6.9 kpc and lying in the MIPSGAL field of view. Among the remaining bubbles we identify also a H II region and a proto-planetary nebula candidate.
Enabling Green Innovations for the Circular Economy: What Factors Matter?

Recent economic theory and international evidence have established that innovations with environmental benefits (green innovations) are crucially important to increase resource efficiency and accelerate the transition to a circular economy. However, robust empirical evidence on what factors drive green innovations at firm-level is limited and inconclusive. To help fill this evidence gap, we designed and used a unified econometric framework to quantify the impact of a comprehensive set of factors on the propensity of firms to introduce innovations with environmental benefits. Such factors include environmental regulations, innovation-inputs, firm-specific characteristics, spillovers from other green innovators, public funding, and co-operation for innovation activities. We distinguished and examined innovations with environmental benefits obtained within the firm and innovations with environmental benefits obtained during the consumption of goods or services by the end user. In addition to average effects across all firms, we also uncovered specific effects for different groups of firms and industries. The results indicate that environmental regulations, in-house R&D, and acquisition of capital assets are important factors that enable firms to introduce green innovations. These results have implications for designing policies aiming at enabling more firms to introduce green innovations and thus accelerate the transition to a circular economy and a more sustainable long-term growth.
DYNAMICAL FRAGMENTATION OF THE T PYXIDIS NOVA SHELL DURING RECURRENT ERUPTIONS

Hubble Space Telescope images of the ejecta surrounding the nova T Pyxidis resolve the emission into more than 2000 bright knots. We simulate the dynamical evolution of the ejecta from T Pyxidis during its multiple eruptions over the last 150 years using the adaptive mesh refinement code Ramses. We demonstrate that the observed knots are the result of Richtmyer–Meshkov gas dynamical instabilities (the equivalent of Rayleigh–Taylor instabilities in an accelerated medium). These instabilities are caused by the overrunning of the ejecta from the classical nova of 1866 by fast-moving ejecta from the six subsequent recurrent nova outbursts. Magnetic fields may play a role in determining knot scale and preventing their conductive evaporation. The model correctly predicts the observed expansion and dimming of the T Pyx ejecta as well as the knotty morphology. The model also predicts that deeper, high-resolution imagery will show filamentary structure connecting the knots. We show reprocessed Hubble Space Telescope imagery that shows the first hints of such a structure.
Effect of a Body Part Action on Body Perception of the Other Inactive Body Part

The rubber hand illusion (RHI) is an illusory experience in which a fake rubber hand is felt as if it were one’s own hand when the visible fake and invisible real hands are stimulated synchronously. Although several studies have suggested contributions of action to body ownership using the RHI paradigm, the relationship between body ownership and agency has not yet been fully revealed. To better understand this relationship, the present study investigated the transfer of body ownership between body parts induced by a body part action. Using an RHI paradigm involving virtual reality, we tested whether a simple finger action of the dominant (active) hand can induce the embodiment of a virtual hand corresponding to the nondominant (inactive) hand. We evaluated the illusory experience, perceptual changes, and physiological changes during the experiment with a subjective questionnaire, crossmodal congruency effect measurement, and skin temperature measurement, respectively. The results demonstrated that the finger action induced the embodiment of both virtual hands, causing a significant increase in agency of the inactive hand. This suggests that the illusory experience induced by an active body part contributes to an increase in agency as well as body ownership over the virtual body of the other inactive body part.
Structural Characterization of a Pleurotus sajor-caju Polysaccharide and Its Neuroprotection Related to the Inhibition of Oxidative Stress

A novel polysaccharide PSP2-1 was isolated and purified from Pleurotus sajor-caju. The structural characterization data displayed that the molecular weight of PSP2-1 was 44.9 kDa, and PSP2-1 consisted of fucose, galactose, glucose, and mannose. The methylation results showed that the glycosidic bonds of PSP2-1 included T-Fuc, 1,6-Gal, T-Glc, 1,6-Glc, 1,3,6-Glc, 1,3-Man, 1,2,6-Man, and T-Man. Neuroprotective studies indicated that PSP2-1 significantly improved the cell viability of the H2O2-induced oxidatively damaged neuronal cell HT22, reduced the release of LDH, inhibited apoptosis and release of cytochrome c, and alleviated the decline of mitochondrial membrane potential and ROS accumulation. Furthermore, PSP2-1 decreased the phosphorylation levels of cleaved PARP and cleaved caspase-3, and increased the ratio of bcl-2/bax. Additionally, PSP2-1 could inhibit the phosphorylation of MAPK family members including JNK, p38, and Erk. Finally, animal experiments showed that PSP2-1 could improve the oxidative stress injury and the learning and memory ability of mice with aging induced by D-galactose. Our results confirmed that PSP2-1 significantly ameliorated the oxidative stress injury, inhibited the apoptosis in H2O2-induced neuronal cells via MAPK pathway, and also improved cognition in mice with aging induced by D-galactose. Our research gives the foundation for the functional food application of P. sajor-caju polysaccharides in the future.
Climate and climate change in a radiative‐convective equilibrium version of ECHAM6

A radiative‐convective equilibrium (RCE) configuration of a comprehensive atmospheric general circulation model, ECHAM6, is coupled to a mixed‐layer ocean for the purpose of advancing understanding of climate and climate change. This configuration differs from a standard configuration only through the removal of land‐surface processes, spatial gradients in solar insolation, and the effects of rotation. Nonetheless, the model produces a climate that resembles the tropical climate in a control simulation of Earth's atmosphere. In the RCE configuration, regional inhomogeneities in surface temperature develop. These inhomogeneities are transient in time but sufficiently long‐lived to establish large‐scale overturning circulations with a distribution similar to the preindustrial tropics in the standard configuration. The vertical structure of the atmosphere, including profiles of clouds and condensate conditioned on the strength of overturning, also resembles those produced by a control simulation of Earth's tropical atmosphere. The equilibrium climate sensitivity of the RCE atmosphere can explain 50% of the global climate sensitivity of a realistic configuration of ECHAM6. Part of the difference is attributed to the lack of polar amplification in RCE. The remainder appears to be related to a less positive cloud shortwave feedback, which results from an increase in low cloudiness with increasing surface temperatures in the RCE configuration. The RCE configuration shows an increase of climate sensitivity in a warmer climate. The increase in climate sensitivity scales with the degree to which the upper‐troposphere temperature departs from a moist adiabat.
Coherence of tricategories

Interestingly, coherence of tricategories that you really wait for now is coming. It's significant to wait for the representative and beneficial books to read. Every book that is provided in better way and utterance will be expected by many peoples. Even you are a good reader or not, feeling to read this book will always appear when you find it. But, when you feel hard to find it as yours, what to do? Borrow to your friends and don't know when to give back it to her or him.
Electromagnetic perturbations in new brane world scenarios

In this work, we consider electromagnetic dynamics in Randall-Sundrum branes. It is derived from a family of four-dimensional spacetimes compatible with Randall-Sundrum brane worlds, focusing on asymptotic flat backgrounds. Maximal extensions of the solutions are constructed, and their causal structures are discussed. These spacetimes include singular, nonsingular, and extreme black holes. Maxwell’s electromagnetic field is introduced, and its evolution is studied in an extensive numerical survey. Electromagnetic quasinormal mode spectra are derived and analyzed with time-dependent and high-order WKB methods. Our results indicate that the black holes in the brane are electromagnetically stable.
A SURVEY OF INFRARED SUPERNOVA REMNANTS IN THE LARGE MAGELLANIC CLOUD

We present a comprehensive infrared study of supernova remnants (SNRs) in the Large Magellanic Cloud (LMC) using near- to mid-infrared images taken by Infrared Array Camera (IRAC; 3.6, 4.5, 5.8, and 8 μm) and Multiband Imaging Photometer (MIPS; 24 and 70 μm) onboard the Spitzer Space Telescope. Among the 47 bona fide LMC SNRs, 29 were detected in infrared, giving a high detection rate of 62%. All 29 SNRs show emission at 24 μm, and 20 out of 29 show emission in one or several IRAC bands. We present their 4.5, 8, 24, and 70 μm images and a table summarizing their Spitzer fluxes. We find that the LMC SNRs are considerably fainter than the Galactic SNRs, and that, among the LMC SNRs, Type Ia SNRs are significantly fainter than core-collapse SNRs. We conclude that the MIPS emission of essentially all SNRs originates from dust emission, whereas their IRAC emissions originate from ionic/molecular lines, polycyclic aromatic hydrocarbons emission, or synchrotron emission. The infrared fluxes show correlation with radio and X-ray fluxes. For SNRs that have similar morphology in infrared and X-rays, the ratios of 24 to 70 μm fluxes have good correlation with the electron density of hot plasma. The overall correlation is explained well by the emission from collisionally heated silicate grains of 0.1 μm size, but for mature SNRs with relatively low gas temperatures, the smaller-sized grain population is favored more. For those that appear different between infrared and X-rays, the emission in the MIPS bands is probably from dust heated by shock radiation.
REVERBERATION MAPPING OF THE SEYFERT 1 GALAXY NGC 7469

A large reverberation-mapping study of the Seyfert 1 galaxy NGC 7469 has yielded emission-line lags for Hβ λ4861 and He ii λ4686 and a central black hole mass measurement MBH ≈ 1 × 107 M☉, consistent with previous measurements. A very low level of variability during the monitoring campaign precluded meeting our original goal of recovering velocity–delay maps from the data, but with the new Hβ measurement, NGC 7469 is no longer an outlier in the relationship between the size of the Hβ-emitting broad-line region and the luminosity of the active galactic nucleus. It was necessary to detrend the continuum and Hβ and He ii λ4686 line light curves and those from archival UV data for different time-series analysis methods to yield consistent results.
THE INFRARED SPECTRAL PROPERTIES OF MAGELLANIC CARBON STARS

The Infrared Spectrograph on the Spitzer Space Telescope observed 184 carbon stars in the Magellanic Clouds. This sample reveals that the dust-production rate (DPR) from carbon stars generally increases with the pulsation period of the star. The composition of the dust grains follows two condensation sequences, with more SiC condensing before amorphous carbon in metal-rich stars, and the order reversed in metal-poor stars. MgS dust condenses in optically thicker dust shells, and its condensation is delayed in more metal-poor stars. Metal-poor carbon stars also tend to have stronger absorption from C2H2 at 7.5 μm. The relation between DPR and pulsation period shows significant apparent scatter, which results from the initial mass of the star, with more massive stars occupying a sequence parallel to lower-mass stars, but shifted to longer periods. Accounting for differences in the mass distribution between the carbon stars observed in the Small and Large Magellanic Clouds reveals a hint of a subtle decrease in the DPR at lower metallicities, but it is not statistically significant. The most deeply embedded carbon stars have lower variability amplitudes and show SiC in absorption. In some cases they have bluer colors at shorter wavelengths, suggesting that the central star is becoming visible. These deeply embedded stars may be evolving off of the asymptotic giant branch and/or they may have non-spherical dust geometries.
Pancreatic Cancer Cells Induce MicroRNA Deregulation in Platelets

Pancreatic cancer is a pathology with a high mortality rate since it is detected at advanced stages, so the search for early-stage diagnostic biomarkers is essential. Liquid biopsies are currently being explored for this purpose and educated platelets are a good candidate, since they are known to present a bidirectional interaction with tumor cells. In this work, we analyzed the effects of platelets on cancer cells’ viability, as determined by MTT, migration using transwell assays, clonogenicity in soft agar and stemness by dilution assays and stem markers’ expression. We found that the co-culture of platelets and pancreatic cancer cells increased the proliferation and migration capacity of BXCP3 cells, augmented clonogenicity and induced higher levels of Nanog, Sox2 and Oct4 expression. As platelets can provide horizontal transfer of microRNAs, we also determined the differential expression of miRNAs in platelets obtained from a small cohort of pancreatic cancer patients and healthy subjects. We found clear differences in the expression of several miRNAs between platelets of patients with cancer healthy subjects. Moreover, when we analyzed microRNAs from the platelets of the pancreatic juice and blood derived from each of the cancer patients, interestingly we find differences between the blood- and pancreatic juice-derived platelets suggesting the presence of different subpopulations of platelets in cancer patients, which warrant further analysis.
A multiferroic on the brink: Uncovering the nuances of strain-induced transitions in BiFeO3

Bismuth ferrite (BiFeO3) is one of the very few known single-phase multiferroic materials. While the bulk compound is rhombohedral (R), the discovery of an epitaxial strain-induced structural transition into a so-called “super tetragonal phase” (T-phase) in this material incited a flurry of research activity focused on gaining an understanding of this phase transition and its possible functionalities. This metastable phase of BiFeO3 is also multiferroic, with giant ferroelectricpolarization and coexisting antiferromagnetic order, but above all it is the strain relaxation-induced phase mixtures and their outstanding piezoelectric and magnetoelectric responses which continue to intrigue and motivate the physicist and materials scientist communities. Here, we review the research into the T-phase and mixed-phase BiFeO3 system. We begin with a brief summary of the history of the T-phase and an analysis of the structure of the various phases reported in the literature. We then address important questions regarding the symmetry and octahedral rotation patterns and the (as yet underexplored) important role of chemistry in the formation of the metastable T-phase. We follow by describing the phase transitions in this material, and how these may hold promise for large magnetoelectric responses. Finally, we point out some experimental challenges inherent to the study of such a system, and potential pathways for how they may be overcome. It is our intention with this work to highlight important issues that, in our opinion, should be carefully considered by the community in order to use this fascinating materials system for a new paradigm of functionality.
Effect of Dry Needling Treatment on Tibial Musculature in Combination with Neurorehabilitation Treatment in Stroke Patients: Randomized Clinical Study

(1) Background: Introducing ultrasound-guided dry needling to neurorehabilitation treatments increases the beneficial effects of therapy. The aim of this study was to compare the effects of including an ultrasound-guided dry needling session in neurorehabilitation treatment on spasticity and gait–balance quality versus neurorehabilitation treatment in subjects who had suffered a stroke. (2) Methods: A single-blind, randomized clinical trial was conducted. Thirty-six patients who had suffered a stroke in the right middle cerebral artery signed the informed consent for participation in the study. Twenty patients finally participated and were randomly assigned to the control group (neurorehabilitation treatment) or experimental group (neurorehabilitation treatment plus ultrasound-guided dry needling). Pre-treatment and post-treatment data were collected on the same day. The experimental group (n = 10) first underwent an ultrasound-guided dry needling intervention on the tibialis anterior and tibialis posterior musculature, followed by neurorehabilitation treatment; the control group (n = 10) underwent their corresponding neurorehabilitation without the invasive technique. Pre-treatment and post-treatment measurements were taken on the same day, assessing the quality of balance–gait using the “Up and Go” test and the degree of spasticity using the Modified Modified Ashworth Scale. (3) Results: The patients who received neurorehabilitation treatment plus ultrasound-guided dry needling showed a greater decrease in spasticity in the tibial musculature after the neurorehabilitation treatment session (p < 0.001), improving balance and gait (p < 0.001). (4) Conclusions: An ultrasound-guided dry needling session combined with neurorehabilitation treatment reduced spasticity and improved balance and gait in stroke patients.
Nutrient limitation of periphytic algal assemblages in agricultural streams across grassland to boreal landscapes

Land-use practices can deteriorate the health of aquatic ecosystems in lower-order streams by increasing the availability of nutrients to periphytic algae. The magnitude of eutrophication likely depends in part on the nature of nutrient limitation and other local environmental factors. We used nutrient diffusing substrates and assessments of taxonomically diagnostic pigments to experimentally identify the drivers of nutrient limitation of periphytic algal assemblages across 30 streams which collectively spanned a gradient of agricultural land-use intensity (cropland, pasture, and nutrients) across Boreal Forest, Grassland, and Parkland ecoregions in Alberta, Canada. We identified N as the primary limiting factor of total algal biomass accrual. Overall, bacillariophytes made up most of the total algal biomass response to N. Dissolved inorganic N to total P ratios in the water column were consistently low, and P amendment altered assemblage composition by stimulating chlorophytes over bacillariophytes. Differences in soil types, precipitation, runoff, and leaching potential within and across ecoregions did not alter the algal responses to the experimental nutrient amendments. The effect of N-limiting conditions observed across most streams had greater relative importance than other potential abiotic factors (e.g., light) on algal growth. Whereas a historical focus on P management remains important, our findings highlight the need to increase the attention and focus on N in watershed management plans during the summer months to mitigate eutrophication of agricultural streams.
Galaxies with conspicuous optical warps

In this paper, we present results of a photometric and kinematic study for a sample of 13 edge-on spiral galaxies with pronounced integral-shape warps of their stellar discs. The global structure of the galaxies is analyzed on the basis of the Sloan Digital Sky Survey (SDSS) imaging, in the g, r and i passbands. Spectroscopic observations are obtained with the 6-m Special Astrophysical Observatory telescope. In general, galaxies of the sample are typical bright spiral galaxies satisfying the Tully-Fisher relation. Most of the galaxies reside in dense spatial environments and, therefore, tidal encounters are the most probable mechanism for generating their stellar warps. We carried out a detailed analysis of the galaxies and their warps and obtained the following main results: (i) maximum angles of stellar warps in our sample are about 20°; (ii) warps start, on average, between 2 and 3 exponential scale lengths of a disc; (iii) stronger warps start closer to the center, weak warps start farther; (iv) warps are asymmetric, with the typical degree of asymmetry of about several degrees (warp angle); (v) massive dark halo is likely to preclude the formation of strong and asymmetric warps.