Miracle-dz/UniFAR-FTUs huggingface dataset:
Olanzapine/samidorphan combination consistently mitigates weight gain across various subgroups of patients

Abstract Objective A combination of olanzapine and the opioid receptor antagonist samidorphan (OLZ/SAM) has been approved in the United States for the treatment of adults with schizophrenia or adults with bipolar I disorder. In a phase 3 study in adults with schizophrenia (ENLIGHTEN-2), OLZ/SAM treatment was associated with significantly less weight gain compared with olanzapine. Prespecified subgroup analyses explored the consistency of the weight mitigation effect of OLZ/SAM vs olanzapine across demographic subgroups in ENLIGHTEN-2. Methods The multicenter, randomized, double-blind ENLIGHTEN-2 study (NCT02694328) included outpatients aged 18–55 years with a diagnosis of schizophrenia based on DSM-5 criteria, a body mass index (BMI) of 18 to 30 kg/m2, and stable body weight (self-reported change ≤5% for ≥3 months before study entry). Patients were randomized 1:1 to receive OLZ/SAM or olanzapine for 24 weeks. Co-primary endpoints (previously reported) were percent change in body weight and proportion of patients with at least 10% weight gain from baseline at week 24. Prespecified exploratory subgroup analyses by sex, age, self-reported race, and baseline BMI were conducted. Results At week 24, treatment with OLZ/SAM resulted in numerically less percent weight gain than with olanzapine across all subgroups evaluated. The proportion of patients with at least 10% weight gain was smaller in each subgroup treated with OLZ/SAM vs olanzapine. Conclusion In these exploratory subgroup analyses from the ENLIGHTEN-2 study, weight-mitigating effects of OLZ/SAM vs olanzapine were observed consistently across patient subgroups and were in line with results from the overall study population.
GARROTXA COSMOLOGICAL SIMULATIONS OF MILKY WAY-SIZED GALAXIES: GENERAL PROPERTIES, HOT-GAS DISTRIBUTION, AND MISSING BARYONS

We introduce a new set of simulations of Milky Way (MW)-sized galaxies using the AMR code ART + hydrodynamics in a Λ cold dark matter cosmogony. The simulation series is called GARROTXA and it follows the formation of a halo/galaxy from z = 60 to z = 0. The final virial mass of the system is ∼7.4 × 1011 M⊙. Our results are as follows. (a) Contrary to many previous studies, the circular velocity curve shows no central peak and overall agrees with recent MW observations. (b) Other quantities, such as (6 × 1010M⊙) and Rd (2.56 kpc), fall well inside the observational MW range. (c) We measure the disk-to-total ratio kinematically and find that D/T = 0.42. (d) The cold-gas fraction and star formation rate at z = 0, on the other hand, fall short of the values estimated for the MW. As a first scientific exploitation of the simulation series, we study the spatial distribution of hot X-ray luminous gas. We have found that most of this X-ray emitting gas is in a halo-like distribution accounting for an important fraction but not all of the missing baryons. An important amount of hot gas is also present in filaments. In all our models there is not a massive disk-like hot-gas distribution dominating the column density. Our analysis of hot-gas mock observations reveals that the homogeneity assumption leads to an overestimation of the total mass by factors of 3–5 or to an underestimation by factors of 0.7–0.1, depending on the used observational method. Finally, we confirm a clear correlation between the total hot-gas mass and the dark matter halo mass of galactic systems.
Magnetic-field-induced nonlocal effects on the vortex interactions in twin-free YBa2Cu3O7

The vortex lattice (VL) in the high-κ superconductor YBa2Cu3O7, at 2 K and with the magnetic field parallel to the crystal c axis, undergoes a sequence of transitions between different structures as a function of applied magnetic field. However, from structural studies alone, it is not possible to determine precisely the system anisotropy that governs the transitions between different structures. To address this question, here we report new small-angle neutron scattering measurements of both the VL structure at higher temperatures and the field and temperature dependence of the VL form factor. Our measurements demonstrate how the influence of anisotropy on the VL, which in theory can be parameterized as nonlocal corrections, becomes progressively important with increasing magnetic field, and suppressed by increasing the temperature toward Tc. The data indicate that nonlocality due to different anisotropies plays an important role in determining the VL properties.
Microencapsulation of Phenolic Extract from Sea Grape (Coccoloba uvifera L.) with Antimutagenic Activity

This study aimed to microencapsulate the sea grape ethanolic extract by the spray drying process, characterizing the obtained powder, and evaluating its antimutagenicity activity. Microparticles showed a mean size of 6.28 μm and a spherical shape with a smooth surface. The powder had a low moisture content (4.02±0.92 %) and water activity (0.27±0.01), and high solubility (76±3.60 %). Moreover, hygroscopicity (14.75±2.63 g/100 g of powder) and bulk density (0.63±0.03 g/cm3) values suggested that this powder can be easily handled at a pilot or industrial scale. In addition, microencapsulation protected the extract against oxidation by ultraviolet light, improved its thermal stability, and its antimutagenicity activity was similar to fresh sea grape extract. In conclusion, the microencapsulation with maltodextrin by spray drying technique is an alternative to protect bioactive compounds from sea grapes against environmental conditions, maintaining their antimutagenic activity.
Cannabis use for Sleep Disturbance Among Older Patients in a Geriatrics Clinic

Cannabis use is growing among older adults to manage medical concerns including poor sleep. In this study, we characterized how patients seen at a geriatrics clinic use cannabis to address sleep disturbance. Specifically, we conducted an anonymous survey of 568 adults, including 83 who reported cannabis use within the past 3 years, to inquire about such use. We compared cannabis use characteristics between those using it for sleep disturbance versus all other conditions. We considered a p-value <. 10 to be statistically significant. Among the cannabis users in our sample, 29% reported using cannabis for sleep disturbance (N = 24). They were more likely than other users to be female (p = .07), consume cannabis more frequently (p = .01), use products containing tetrahydrocannabinol (THC) (vs. cannabidiol [CBD]-only; p < .01), and use cannabis to target more symptoms (p < .01). As cannabis use continues to grow in older populations, it is essential to delineate better how cannabis may be used safely and effectively to improve older adults’ sleep health.
AEGIS: THE MORPHOLOGIES OF GREEN GALAXIES AT 0.4 < z < 1.2

We present quantitative morphologies of ∼300 galaxies in the optically defined green valley at 0.4 < z < 1.2, in order to constrain the mechanism(s) responsible for quenching star formation in the bulk of this population. The sample is selected from galaxies in the All-Wavelength Extended Groth Strip International Survey (AEGIS). While the green valley is defined using optical U − B colors, we find that using a green valley sample defined using NUV − R colors does not change the results. Using Hubble Space Telescope/Advanced Camera for Surveys imaging, we study several quantitative morphological parameters including CAS, B/T from GIM2D, and Gini/M20. We find that the green galaxy population is intermediate between the red and blue galaxy populations in terms of concentration, asymmetry, and morphological type and merger fraction estimated using Gini/M20. We find that most green galaxies are not classified as mergers; in fact, the merger fraction in the green valley is lower than in the blue cloud. We show that at a given stellar mass, green galaxies have higher concentration values than blue galaxies and lower concentration values than red galaxies. Additionally, we find that 12% of green galaxies have B/T = 0 and 21% have B/T ⩽ 0.05. Our results show that green galaxies are generally massive (M* ∼ 1010.5 M☉) disk galaxies with high concentrations. We conclude that major mergers are likely not the sole mechanism responsible for quenching star formation in this population and that either other external processes or internal secular processes play an important role both in driving gas toward the center of these galaxies and in quenching star formation.
Comparison of the kinetics and magnitude of antibody responses to different SARS-CoV-2 proteins in Sinopharm/BBIBP-CorV vaccinees following the BNT162b2 booster or natural infection

The kinetics and magnitude of antibody responses to different proteins of the SARS-CoV-2 virus in Sinopharm/BBIBP-CorV vaccinees has not been previously studied. Therefore, we investigated antibody responses to different SARS-CoV-2 proteins at 2 weeks, 3 months, and 6 months post-second dose in previously infected (n = 20) and uninfected (n = 20) Sinopharm/BBIBP-CorV vaccinees. The IgG antibodies to the S, S1 and S2 and N were several folds higher in those who had natural infection compared to uninfected individuals at all time points. We then compared the persistence of antibody responses and effect of natural omicron infection or BNT162b2 booster in Sinopharm/BBIBP-CorV vaccinees. We measured the total antibodies to the RBD, ACE2 blocking antibodies and antibody responses to different SARS-CoV-2 proteins in Sinopharm vaccinees at 7 months post second dose, including those who remained uninfected and not boosted (n = 21), or those who had previous infection and who did not obtain the booster (n = 17), those who were not infected, but who received a BNT162b2 booster (n = 30), or those who did not receive the booster but were infected with omicron (n = 29). At 7 months post second dose uninfected (no booster) had the lowest antibody levels to the RBD, while omicron infected vaccinees showed significantly higher anti-RBD antibody levels (p = 0.04) than vaccinees who received the booster. Only 3/21 cohort A (14.3%) had ACE2 blocking antibodies, while higher frequencies were observed in naturally infected individuals (100%), those who received the booster (18/21, 85.7%), and omicron infected individuals (100%). Pre-vaccination, naturally infected had the highest antibody levels to the N protein. These data suggest that those previously infected Sinopharm/BBIBP-CorV vaccinees have a robust antibody response, 7 months post vaccination, while vaccinees who were naturally infected with omicron had a similar immune response to those who received the booster. It will be important to investigate implications for subsequent clinical protection.
The gut microbiome: an overview of current trends and risks for paediatric populations

Purpose of review Gut health is an increasingly popular topic of discussion among scientists and the general population alike. As interest surrounding the gut microbiome grows, the accessibility to misinformation and unfounded gut health trends to youth is likely to emerge as a public health concern. The purpose of this review is to provide paediatricians with current information about the gut microbiome, as well as explanations and possible risks of the multitude of gut health trends that adolescents may be exposed to. Recent findings The gut microbiome is implicated in overall health by playing roles in digestion, immunity and mental health. Novel microbiome-related therapies, such as faecal microbiota transplants, and the gut-brain link show the therapeutic potential of the gut microbiome. However, unproven dietary fads and trends on social media are rampant as well, such as ginger juice shots. In addition, paediatric supplements meant to target gut health are unregulated, yet are highly marketed. Improperly applying these trends and diets may result in risks of malnutrition and body image issues for impressionable children. Summary Increased familiarity regarding the types of gut health trends and diets among young people will allow paediatricians to more effectively advise their patients about potential risks and good gut health practices. Paediatricians and caregivers serve as role models and educators with regard to children's perceptions and management of their gut and overall health.
Exosomal epidermal growth factor receptor is involved in HPV-16 E7-induced epithelial-mesenchymal transition of non-small cell lung cancer cells: A driver of signaling in vivo

ABSTRACT Our previous studies have demonstrated that human papillomavirus (HPV)-16 E7 oncoprotein promoted epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) cells. Moreover, recent studies have found that exosomes can mediate EMT of NSCLC cells and epidermal growth factor receptor (EGFR) is related to the progression of NSCLC. Here, we further investigated the role of exosomal EGFR in HPV-16 E7-induced EMT of NSCLC cells. Our results showed that the exosomes derived from the stable HPV-16 E7-overexpressing A549 and NCI-H460 NSCLC cells (E7 Exo) significantly increased migration, invasion, and proliferation abilities of NSCLC cells as compared with the exosomes derived from empty vector-infected NSCLC cells (ev Exo). Moreover, both in vitro and in vivo results demonstrated that E7 Exo dramatically enhanced EMT of NSCLC cells and promoted the growth of subcutaneous NSCLC xenografts. Additionally, HPV-16 E7 enhanced the expression of EGFR and p-EGFR in both NSCLC cells and exosomes. Furthermore, the inhibition of EGFR activation or exosome secretion suppressed E7 Exo-induced migration, invasion, and EMT of NSCLC. Moreover, 12 kinds of differentially expressed miRNAs between E7 Exo and ev Exo (fold change≥2, P ≤ .05) were screened out, of which 7 miRNAs were up-regulated while 5 miRNAs were down-regulated in A549 E7 Exo. Taken together, our findings suggest that exosomal EGFR is involved in HPV-16 E7-induced EMT of NSCLC cells, which may play a key role in the progression of HPV-related NSCLC.
Hypothesis review: Alzheimer's overture guidelines

National Institute on Aging–Alzheimer's Association definition and classification of sporadic Alzheimer's disease (sAD) is based on the assumption that β‐amyloid drives the pathogenesis of sAD, and therefore, β‐amyloid pathology is the sine‐qua‐non condition for the diagnosis of sAD. The neuropathological diagnosis is based on the concurrence of senile plaques (SPs) and neurofibrillary tangles (NFTs) designated as Alzheimer's disease neuropathological changes. However, NFTs develop in the brain decades before the appearance of SPs, and their distribution does not parallel the distribution of SPs. Moreover, NFTs are found in about 85% of individuals at age 65 and around 97% at age 80. SPs occur in 30% at age 65 and 50%–60% at age 80. More than 70 genetic risk factors have been identified in sAD; the encoded proteins modulate cell membranes, synapses, lipid metabolism, and neuroinflammation. Alzheimer's disease (AD) overture provides a new concept and definition of brain aging and sAD for further discussion. AD overture proposes that sAD is: (i) a multifactorial and progressive neurodegenerative biological process, (ii) characterized by the early appearance of 3R + 4Rtau NFTs, (iii) later deposition of β‐amyloid and SPs, (iv) with particular non‐overlapped regional distribution of NFTs and SPs, (v) preceded by or occurring in parallel with molecular changes affecting cell membranes, cytoskeleton, synapses, lipid and protein metabolism, energy metabolism, neuroinflammation, cell cycle, astrocytes, microglia, and blood vessels; (vi) accompanied by progressive neuron loss and brain atrophy, (vii) prevalent in human brain aging, and (viii) manifested as pre‐clinical AD, and progressing not universally to mild cognitive impairment due to AD, and mild, moderate, and severe AD dementia.
The effect of radiation pressure on dusty absorbing gas around active galactic nuclei

Many active galactic nuclei (AGN) are surrounded by gas which absorbs the radiation produced by accretion on to the central black hole and obscures the nucleus from direct view. The dust component of the gas greatly enhances the effect of radiation pressure above that for Thomson scattering so that an AGN which is sub-Eddington for ionized gas in the usual sense can appear super-Eddington for cold dusty gas. The radiation pressure enhancement factor depends on the AGN spectrum but ranges between unity and about 500, depending on the column density. It means that an AGN for which the absorption is long-lived should have a column density of NH > 5 × 10 23 λ cm −2 , where λ is its Eddington fraction Lbol/LEdd, provided that NH > 5 × 10 21 cm −2 . We have compared the distribution of several samples of AGN ‐ local, Chandra Deep Field-South and Lockman Hole ‐ with this expectation and find good agreement. We show that the limiting enhancement factor can explain the black hole mass‐bulge mass relation and note that the effect of radiation pressure on dusty gas may be a key component in the feedback of momentum and energy from a central black hole to a galaxy.
Keeping the conversation going: How progressivity is prioritised in co-remembering talk between couples impacted by dementia

This article explores how partners keep the conversation going with people living with dementia (PLWD) when speaking about shared memories. Remembering is important for PLWD and their families. Indeed, memory loss is often equated with identity loss. In conversation, references to shared past events (co-rememberings) can occasion interactional trouble if memories cannot be mutually recalled. This article analyses partners’ interactional practices that enable progressivity in conversations about shared memories with a PLWD. In previous research, both informal and formal carers have reported that they can find interacting with PLWD difficult. Identifying practices used by partners is one way to begin addressing those difficulties. Analytical findings are based on over 26 hours of video data from domestic settings where partners have recorded their interactions with their spouse/close friend who is living with dementia. The focus is on 14 sequences of conversation about shared memories. We show how particular practices (candidate answers, tag questions and single-party memory of a shared event) structure the interaction to facilitate conversational progression. When partners facilitate conversational progressivity, PLWD are less likely to experience stalls in conversation. Our findings suggest the actual recall of memory is less relevant than the sense of shared connection resulting from the conversational activity of co-remembering, aiding maintenance of individual and shared identities. These findings have relevance for wider care settings.
Explaining the Praesepe blue straggler HD 73666

The blue straggler phenomenon is not yet well explained by current theory; however, evolutionary models of star clusters call for a good knowledge of it. Here we try to understand the possible formation scenario of HD 73666, a blue straggler member of the Praesepe cluster. We compile the known physical properties of HD 73666 found in the literature, focusing in particular on possible binarity and the abundance pattern. HD 73666 appears to be slowly rotating, has no detectable magnetic field, and has normal abundances, thereby excluding close binary evolution and mass transfer processes. There is no evidence of a hot radiation source. With the use of theoretical results on blue straggler formation present in literature, we are able to conclude that HD 73666 was probably formed by physical collision involving at least one binary system, between 5 and 350 Myr (50 Myr if the star is an intrinsic slow rotator) ago.
The detection of globular clusters in galaxies as a data mining problem

ABSTRACT We present an application of self-adaptive supervised learning classiﬁers derived fromthe Machine Learning paradigm, to the identiﬁcation of candidate Globular Clus-ters in deep, wide-ﬁeld, single band HST images. Several methods provided by theDAME (Data Mining & Exploration) web application, were tested and compared onthe NGC1399 HST data described in Paolillo et al. (2011). The best results were ob-tained using a Multi LayerPerceptronwith Quasi Newton learningrule which achieveda classiﬁcation accuracy of 98.3%, with a completeness of 97.8% and 1.6% contami-nation. An extensive set of experiments revealed that the use of accurate structuralparameters (eﬀective radius, central surface brightness) does improve the ﬁnal result,but only by ∼5%. It is also shown that the method is capable to retrieve also extremesources (for instance, very extended objects) which are missed by more traditionalapproaches.Key words: Globular clusters; elliptical galaxies; NGC1399; Machine Learning
Impaired spatial navigation and age‐dependent hippocampal synaptic dysfunction are associated with chronic inflammatory response in db/db mice

Type 2 diabetes mellitus (T2DM) increases the risk of developing Alzheimer's disease (AD), which has been proposed to be driven by an abnormal neuroinflammatory response affecting cognitive function. However, the impact of T2DM on hippocampal function and synaptic integrity during aging has not been investigated. Here, we investigated the effects of aging in T2DM on AD‐like pathology using the leptin receptor‐deficient db/db mouse model of T2DM. Our results indicate that adult T2DM mice exhibited impaired spatial acquisition in the Morris water maze (MWM). Morphological analysis showed an age‐dependent neuronal loss in the dentate gyrus. We found that astrocyte density was significantly decreased in all regions of the hippocampus in T2DM mice. Our analysis showed that microglial activation was increased in the CA3 and the dentate gyrus of the hippocampus in an age‐dependent manner in T2DM mice. However, the expression of presynaptic marker protein (synaptophysin) and the postsynaptic marker protein [postsynaptic density protein 95 (PSD95)] was unchanged in the hippocampus of adult T2DM mice. Interestingly, synaptophysin and PSD95 expression significantly decreased in the hippocampus of aged T2DM mice, suggesting an impaired hippocampal synaptic integrity. Cytokine profiling analysis displayed a robust pro‐inflammatory cytokine profile in the hippocampus of aged T2DM mice compared with the younger cohort, outlining the role of aging in exacerbating the neuroinflammatory profile in the diabetic state. Our results suggest that T2DM impairs cognitive function by promoting neuronal loss in the dentate gyrus and triggering an age‐dependent deterioration in hippocampal synaptic integrity, associated with an aberrant neuroinflammatory response.
Brain structure in autoimmune Addison’s disease

Abstract Long-term disturbances in cortisol levels might affect brain structure in individuals with autoimmune Addison’s disease (AAD). This study investigated gray and white matter brain structure in a cohort of young adults with AAD. T1- and diffusion-weighted images were acquired for 52 individuals with AAD and 70 healthy controls, aged 19–43 years, using magnetic resonance imaging. Groups were compared on cortical thickness, surface area, cortical gray matter volume, subcortical volume (FreeSurfer), and white matter microstructure (FSL tract-based spatial statistics). Individuals with AAD had 4.3% smaller total brain volume. Correcting for head size, we did not find any regional structural differences, apart from reduced volume of the right superior parietal cortex in males with AAD. Within the patient group, a higher glucocorticoid (GC) replacement dose was associated with smaller total brain volume and smaller volume of the left lingual gyrus, left rostral anterior cingulate cortex, and right supramarginal gyrus. With the exception of smaller total brain volume and potential sensitivity of the parietal cortex to GC disturbances in men, brain structure seems relatively unaffected in young adults with AAD. However, the association between GC replacement dose and reduced brain volume may be reason for concern and requires follow-up study.