Miracle-dz/UniFAR-FTUs huggingface dataset:
Life satisfaction of Korean Vietnam War Veterans in later life: A lifespan approach

ABSTRACT The current study examined correlates of life satisfaction among Korean Vietnam War Veterans. The sample included 450 male Veterans from the Korean Vietnam War Veterans Study, surveyed by mail in 2013 (Mean age = 67.4 years old, SD = 3.0). A hierarchical analysis was conducted by entering four blocks of variables: first demographic factors, and then pre-military service, military service, and post-military service variables. Each successive regression analysis showed a significant additional contribution to the variance in life satisfaction. In the final model, Korean Veterans had higher life satisfaction when they were married, had higher monthly income and poorer childhood family environment, appraised their military service in a positive light, and had less stressors after homecoming and better perceived physical health. However, combat exposure and social support after homecoming were not independently associated with life satisfaction in the final model. These results imply that both pre- and post-military service factors, as well as cognitive appraisals of military service, should be considered in understanding the subjective well-being of Korean Vietnam War Veterans in later life.
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY School of Business and Management Industrial Engineering and Management Technology Entrepreneurship MASTER ́S THESIS A BUSINESS INCUBATOR, ACCELERATOR, OR COWORKING SPACE? CASE HEALTH INNOVATION VILLAGE AT GE

Author: Ms Tuula Miettinen Title: A Business Incubator, Accelerator, or Coworking Space? Case Health Innovation Village at GE Department: Industrial Management Year: 2016 Place: Lappeenranta Master’s Thesis. Lappeenranta University of Technology. 97 pages, 12 figures, and 6 tables Examiners: Professor Timo Pihkala and Professor Marita Rautiainen
A long-read amplicon approach to scaling up the metabarcoding of lichen herbarium specimens

﻿Abstract Reference sequence databases are critical to the accurate detection and identification of fungi in the environment. As repositories of large numbers of well-curated specimens, herbaria and fungal culture collections have the material resources to generate sequence data for large number of taxa, and could therefore allow filling taxonomic gaps often present in reference sequence databases. Financial resources to do that are however often lacking, so that recent efforts have focused on decreasing sequencing cost by increasing the number of multiplexed samples per sequencing run while maintaining high sequence quality. Following a previous study that aimed at decreasing sequencing cost for lichen specimens by generating fungal ITS barcodes for 96 specimens using PacBio amplicon sequencing, we present a method that further decreases lichen specimen metabarcoding costs. A total of 384 mixed DNA extracts obtained from lichen herbarium specimens, mostly from the four genera Buellia, Catillaria, Endocarpon and Parmotrema, were used to generate new fungal ITS sequences using a Sequel I sequencing platform and the PacBio M13 barcoded primers. The average success rate across all taxa was high (86.5%), with particularly high rates for the crustose saxicolous taxa (Buellia, Catillaria and others; 93.3%) and the terricolous squamulose taxa (Endocarpon and others; 96.5%). On the other hand, the success rate for the foliose genus Parmotrema was lower (60.4%). With this taxon sampling, greater specimen age did not appear to impact sequencing success. In fact, the 1966–1980 collection date category showed the highest success rate (97.3%). Compared to the previous study, the abundance-based sequence denoising method showed some limitations, but the cost of generating ITS barcodes was further decreased thanks to the higher multiplexing level. In addition to contributing new ITS barcodes for specimens of four interesting lichen genera, this study further highlights the potential and challenges of using new sequencing technologies on collection specimens to generate DNA sequences for reference databases.
Association between social network sites use and mental illness: A meta-analysis

The existing literature shows mixed results of how the use of social networking sites (SNSs) is related to mental health. Some studies provided evidence that SNS users are more mentally healthy because of the exchanged social support, while others argued that users tend to engage in upward social comparison, which would result in mental illness. To shed light on this relationship, we conducted a meta-analytic review to examine a) the association between SNS use and mental illness and b) the factors that moderate the association. A total of 1,451 studies were retrieved from six databases (i.e., Communication & Mass Media Complete, PsycINFO, Academic Search Complete, Web of Science, PubMed, and Medline), among which 37 empirical studies (N = 84,955) were eligible for meta-analysis based on the inclusion criteria (i.e., empirical and quantitative studies with human subjects, including sufficient statistical information for effect size computation, concerned with SNS use and mental illness). Results showed that SNS use is associated with not only the likelihood of experiencing overall mental illness (r = .11) but also specific illness, including depression (r = .10), suicidal ideation (r = .22), schizophrenia/mania (r = .09), and ADHD/hyperactivity (r = .27). In addition, the intensity of SNS use, continuous measurement (vs. categorical), and participants’ health condition were found as positive moderators, whereas adopting social support as the theoretical framework and the proportion of African American participants as negative moderators of the association between SNS use and mental illness. Implications of the current study were discussed.
[Pharmacoepidemiological research of COVID-19 in the Russian Federation EGIDA-2020].

AIM An analysis of coronavirus infection in Russia and evaluation of different AVT regimens effectiveness. MATERIALS AND METHODS The study involved a retrospective analysis of 1082 patient records with laboratory-confirmed COVID-19 in 17 regions of Russia. The number of men and women was equal, mean age 48.718. 1 (median 50). Patients with moderate COVID-19 (85%) versus mild COVID-19 (15%) were characterized by higher age (median 54 vs 21 years; p0.001), higher body mass index (27.8 vs 23.4; p0.001), prevalence of chronic diseases (75.3% vs 8.5%; p0.001), including circulatory system diseases (37.8%). Moderate COVID-19 characterized higher intoxication (10.86.1 vs 4.22.7 days; p0.001) and catarrhal symptoms duration (10.25.4 vs 6.14.1 days; p0.001). RESULTS During hospitalization 92% of the patients received AVT, 77% antibiotics, and 16% corticosteroids. Umifenovir therapy resulted in a significant reduction of intoxication (8.75.5 vs 11.75.5 days; p0.001) and catarrhal symptoms duration (8.85.1 vs 12.04.9 days; p0.001) compared to the group without AVT. The usage of INF reduced intoxication symptoms compared with the group without AVT (8.97.5 vs 11.75.5; p0.05). Therapy with hydroxychloroquine, imidazolylethanamide pentandioic acid, and lopinavir + ritonavir combination did not affect the course of COVID-19. Most of adverse reactions were related to antibiotics. CONCLUSION Umifenovir therapy and inclusion of interferon in AVT regimens was associated improvement in the clinical manifestation of the disease among patients.
Analysis of Return to Play After Modified Broström Lateral Ankle Ligament Reconstruction

Background: Despite marked improvements in stability after lateral ankle ligament repair, many patients do not return to their preinjury activity level. There are few studies addressing athletes’ assessment of their ability to return to play after lateral ankle ligament reconstruction for recurrent instability. Purpose: To determine the rate of return to the preinjury activity level among physically active patients after the modified Broström procedure (MBP) for recurrent lateral ankle instability. Study Design: Case series; Level of evidence, 4. Methods: Included were patients who had undergone a primary MBP by a single surgeon over a 6-year period and had a minimum 24 months of follow-up. A telephone questionnaire was conducted to ascertain the patient’s ability to return to sport and/or work activity at final follow-up. Activity levels were evaluated utilizing the Tegner activity score. Outcome scores and other measured variables were compared between patients who returned to their preinjury level and those who did not. The reasons for failing to return were also documented. Results: Of the 59 patients who met the inclusion criteria, 41 (69%; 20 men and 21 women) participated in the telephone interview. Results indicated that 22 (54%) returned to their prior level of activity (returners). The mean age of returners was 27.2 years; for nonreturners, the mean age was 27.1 years. Most patients (36/41; 88%) were satisfied with surgery and the overall outcome. Of the 19 nonreturners, 7 (37%) noted ankle-related reasons for not returning (pain: 57%; residual instability: 29%; decreased range of motion: 14%), and 12 (63%) cited non–ankle-related reasons. The mean preinjury and postoperative Tegner score for returners was 6.8. Moreover, 7 of 14 (50%) high-level athletes with preinjury Tegner scores ≥8 returned to their preinjury activity level. For high-level athletes who did not return to their previous level, the mean postoperative Tegner score was 6.6, and only 1 (7%) cited an ankle-related reason for not returning. Conclusion: A high patient satisfaction rate was reported after the MBP for recurrent lateral ankle instability. The majority of patients who did not return to their preinjury level cited a non–ankle-related factor as the reason for not returning to sport. This was especially true for the higher level athletes.
Historical droughts in Irish catchments 1767–2016

Recent prolonged dry periods in summer 2018 and spring 2020 have reawakened interest in drought in Ireland, prompting questions regarding historical drought occurrence and potential long‐term risks. Employing 250 years of monthly precipitation and flow reconstructions, we investigate historical drought in Irish catchments evaluating the characteristics (number of events, duration, and deficits) of moderate, severe, and extreme droughts as well as the propagation of meteorological to hydrological drought. Using standardized indices, we identify three distinct catchment types. Cluster 1 catchments, located in the wetter northwest are characterized by small areas, low groundwater storage, and the highest frequency of hydrological drought relative to other catchments. Cluster 3 catchments, located in the drier east and southeast have larger areas, greater groundwater storage, the highest frequency of meteorological drought but the least hydrological droughts. However, once established, droughts in Cluster 3 tend to be more persistent with large accumulated deficits. Cluster 2 catchments, located in the southwest and west, are intermediate to Clusters 1 and 3, with hydrological droughts typically of shorter durations, reduced accumulated deficits but greater mean deficits. The most extreme droughts based on accumulated deficits across all catchments occurred in 1803–1806, 1854–1859, 1933–1935, 1944–1945, 1953–1954, and 1975–1977. Although not as severe, droughts in 1887–1888, 1891–1894, and 1971–1974 also appear as significant extremes. Changes in drought characteristics reveal a complex picture with the direction, magnitude, and significance of trends dependent on the accumulation period used to define drought, the period of record analysed, and the reference period used to standardize indices. Of particular note is a tendency towards shorter, more intense meteorological and hydrological droughts. Our findings offer important insight for drought and water management in Ireland given the paucity of extreme droughts in short observed river flow records.
No Longer Conforming to Stereotypes? Gender, Political Style and Parliamentary Debate in the UK

Abstract Research on political style suggests that where women make arguments that are more emotional, empathetic and positive, men use language that is more analytical, aggressive and complex. However, existing work does not consider how gendered patterns of style vary over time. Focusing on the UK, we argue that pressures for female politicians to conform to stereotypically ‘feminine’ styles have diminished in recent years. To test this argument, we describe novel quantitative text-analysis approaches for measuring a diverse set of styles at scale in political speech data. Analysing UK parliamentary debates between 1997 and 2019, we show that the debating styles of female MPs have changed substantially over time, as women in Parliament have increasingly adopted stylistic traits that are typically associated with ‘masculine’ stereotypes of communication. Our findings imply that prominent gender-based stereotypes of politicians' behaviour are significantly worse descriptors of empirical reality now than they were in the past.
Immune Thrombocytopenic Purpura as a Hemorrhagic Versus Thrombotic Disease: An Updated Insight into Pathophysiological Mechanisms

Immune thrombocytopenic purpura (ITP) is a blood disorder characterized by a low platelet count of (less than 100 × 109/L). ITP is an organ-specific autoimmune disease in which the platelets and their precursors become targets of a dysfunctional immune system. This interaction leads to a decrease in platelet number and, subsequently, to a bleeding disorder that can become clinically significant with hemorrhages in skin, on the mucous membrane, or even intracranial hemorrhagic events. If ITP was initially considered a hemorrhagic disease, more recent studies suggest that ITP has an increased risk of thrombosis. In this review, we provide current insights into the primary ITP physiopathology and their consequences, with special consideration on hemorrhagic and thrombotic events. The autoimmune response in ITP involves both the innate and adaptive immune systems, comprising both humoral and cell-mediated immune responses. Thrombosis in ITP is related to the pathophysiology of the disease (young hyperactive platelets, platelets microparticles, rebalanced hemostasis, complement activation, endothelial activation, antiphospholipid antibodies, and inhibition of natural anticoagulants), ITP treatment, and other comorbidities that altogether contribute to the occurrence of thrombosis. Physicians need to be vigilant in the early diagnosis of thrombotic events and then institute proper treatment (antiaggregant, anticoagulant) along with ITP-targeted therapy. In this review, we provide current insights into the primary ITP physiopathology and their consequences, with special consideration on hemorrhagic and thrombotic events. The accumulated evidence has identified multiple pathophysiological mechanisms with specific genetic predispositions, particularly associated with environmental conditions.
Fragility Functions for Seismic Risk in Regions with Moderate Seismicity

Current seismic risk evaluations are mostly based on approximate vulnerability curves. Damage prediction is improved by considering structural characteristics of building. Such improved fragility functions do not exist for many structures, especially in countries with moderate seismicity. Typical structures of these regions, such as unreinforced masonry buildings URM, differ notably from structures usually considered in seismic risk. Due to low perceived seismic hazard, these types of structures have not been adequately investigated. Moreover, experimental investigations have shown that their deformation capacity is often underestimated. As a consequence, advanced methodologies have not yet been developed. This paper describes the results obtained with an analytical displacement-based methodology to assess the seismic risk in existing buildings through fragility functions. The study is based on URM existing buildings, common in North Western Europe. These low or mid-rise buildings with basements generally do not have significant structural plan irregularities. The impact and the accuracy of several parameters (such as the damage grade definition, the prediction of the ultimate drift, and the strength of the walls) are addressed. The fragility curves obtained are compared to those obtained using empirical methods in a typical existing URM building.
The Effect of Debt to Equity Ratio, Earning Per Share and Company Size on Market Value of Equity With Intellectual Capital As Moderating Variable

The purpose of this study was to examine the effect of debt-to-equity ratio, earnings per share, and company size on market value of equity. In this study, intellectual capital was used as a moderating variable. The samples in this study are companies listed in manufacturing companies in 2017-2019 periods on the IDX. Data was processed using the method of moderated regression analysis (Rev Mou1). The results of this study found that debt to debt-to-equity ratio and company size affect the market value of equity meanwhile earning per share can’t affect the market value of equity. Intellectual capital can moderate the effect of debt-to-equity ratio and company size on market value of equity. Based on the results, intellectual capital cannot moderate the effect of earnings per share on market value of equity.
Proximal airway obstruction caused by adenoid cystic carcinoma in a pregnant woman: A case report

Abstract Respiratory tumours are very rare during pregnancy. Here, we report a case of a primigravida woman diagnosed at 27 weeks’ gestation with stridor and dyspnoea, and a primary tracheal tumour. To the best of our knowledge, this is a 4th case report of tracheal adenoid cystic carcinoma during pregnancy. Our staged management of airway obstruction during pregnancy and definite treatment are discussed.
A Comparison between Online and Offline Health Seeking Information using Social Networks for Patients with Chronic Health Conditions

The patient is now better connected with other patients just like the consumer is now better connected with other consumers in particular through the growing adoption of social media and online peer to peer communities. These relationships which become collaborative have either positive or indeed negative consequences that may either endorse or have implications for a firm’s products [32]. The aim of this research was to gain an understanding of the impact social media has on patient influence on healthcare provision especially in relation to information seeking and clinical product choice. It compares a group of patients who are predominantly online information seekers with a group who are predominantly offline information seekers. Bias will be eliminated by utilising probability sampling techniques in order to be able to perform statistical analysis on the results obtained. This study capitalises on having access to approximately 8000+ Direct to Patient consumers who are currently receiving devices for the management of their bladder problems. The intention of this research project is to gain an understanding of how two way online interactions have developed between patients with similar chronic medical conditions and how firms can use online social media to improve their relationship with patients. The key research question of this paper is: Have online social media tools affected demand for healthcare intermediation in patients, who experience chronic medical conditions and reflect a need to become better informed. The findings of this pre-Covid research were that, for patient groups that had chronic conditions, there was a positive relationship between time spent in developed peer to peer communities, are more trusting of online information and spend more time online © 2022, International Journal of Advanced Computer Science and Applications. All Rights Reserved.
Evolution of Short‐Term Seismic Hazard in Alberta, Canada, From Induced and Natural Earthquakes: 2011–2020

We generate short‐term seismic hazard maps for the province of Alberta, Canada, from 2011 through 2020. First, we describe the required adaptations to probabilistic seismic hazard analysis to generate short‐term seismic hazard maps, following the Monte Carlo simulation approach. Second, we identify the natural and induced seismic source areas in Alberta and estimate their earthquake recurrence parameters revealing considerable spatio‐temporal variations in the a $a$ ‐ and b $b$ ‐values in the different seismic clusters in the province. Areas with the highest short‐term seismic hazard during the last decade in Alberta are related to cases of induced seismicity, including hydraulic fracturing activities in the Duvernay Fm. , near Fox Creek, and waste‐water disposal activities near the Musreau Lake. These maps provide a valuable tool to quantify the short‐term evolution in the seismic hazard, which is particularly important considering past and emerging cases of induced seismicity related to the energy sector in Alberta. Furthermore, using parameters from the previous year, we make a seismic hazard forecast for the year 2021. Our analysis provides a baseline of expected short‐term seismic hazard, with inheren uncertainty due to the assumption of unchanged recurrence parameters from the previous year; yet our study reveals pertinent seismicity patterns in line with changing human activities.
NetMix2: Unifying network propagation and altered subnetworks

A standard paradigm in computational biology is to use interaction networks to analyze high-throughput biological data. Two common approaches for leveraging interaction networks are: (1) network ranking, where one ranks vertices in the network according to both vertex scores and network topology; (2) altered subnetwork identification, where one identifies one or more subnetworks in an interaction network using both vertex scores and network topology. The dominant approach in network ranking is network propagation which smooths vertex scores over the network using a random walk or diffusion process, thus utilizing the global structure of the network. For altered subnetwork identification, existing algorithms either restrict solutions to subnetworks in subnetwork families with simple topological constraints, such as connected subnetworks, or utilize ad hoc heuristics that lack a rigorous statistical foundation. In this work, we unify the network propagation and altered subnetwork approaches. We derive a subnetwork family which we call the propagation family that approximates the subnetworks ranked highly by network propagation. We introduce NetMix2, a principled algorithm for identifying altered subnetworks from a wide range of subnetwork families, including the propagation family, thus combining the advantages of the network propagation and altered subnetwork approaches. We show that NetMix2 outperforms network propagation on data simulated using the propagation family. Furthermore, NetMix2 outperforms other methods at recovering known disease genes in pan-cancer somatic mutation data and in genome-wide association data from multiple human diseases. NetMix2 is publicly available at https://github.com/raphael-group/netmix2.