Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of dietary supplementation of fermented fish silage on egg production in Japanese quail (Coturnix coromandelica)

The effect of dietary supplementation of fermented fish silage on egg production in Japanese quail was investigated. Body weight gain, egg production and egg quality parameters (shape index, albumen index, yolk index, shell thickness and Hauge unit) were determined. There was no significant difference observed in the body weight gain in fermented fish silage supplemented birds as compared to that of dried fish waste and unsalted dried fish supplemented groups of birds. The total egg production and egg Internal Quality Unit (Haugh unit) of fermented fish silage fed birds was significantly higher compared to the other groups of birds. The results of the study indicate that incorporation of fermented fish waste silage in the poultry feed formulation can increase the egg production in Japanese quails. Key word: Fermented silage, surimi, Japanese quail, egg production, egg quality, fish waste.
Socio-demographic and regional disparities in utilization of intermittent preventive treatment for malaria in pregnancy - Nigeria demographic health survey 2013

Introduction malaria in pregnancy can lead to medical emergencies. Utilization of intermittent preventive treatment for prevention of malaria in pregnancy with Sulphadoxine- Pyrimethamine (IPTp-SP) has remained low in developing countries in sub-Saharan Africa. This study aimed to identify the factors determining uptake of IPTp-SP in Nigeria using the 2013 Nigeria Demographic Health Survey. Methods we conducted a secondary analysis of data extracted from the National Demographic Health Survey 2013 which used a three stage stratified sampling method to select respondents. Independent variables considered were age, marital status, the level of education of respondents and their spouses, region, location of residence, wealth-index and birth order. The dependent variable was the use of two or more doses of SP for IPTp in the two years before the survey. Descriptive statistics for socio-demographic and selected characteristics was done. Chi-square test was used to test associations between sociodemographic characteristics and IPTp-SP uptake. Multiple logistic regressions at 95% confidence interval were used to determine predictors of IPTp utilization using STATA version14 software. Results of the 38,948 women interviewed 12,473 (32%) had given birth two years preceding the survey and 15% used at least two doses of SP for IPTp. Women aged 30 years and above [aOR 1.4, C.I:1.1-1.7], in the middle class or higher wealth index [aOR 1.5, CI: 1.1-2.0], with two or more ANC visits [aOR 4.2, CI: 1.4 - 12.5], were more likely to use IPTp. Conclusion late initiation of IPTp after the second trimester was a contributory factor for poor SP utilization. Interventions targeted at ensuring pregnant women attend ANC and use of IPTp-SP after quickening should be promoted.
Distinctive clinicopathological features of Von Hippel-Lindau-associated hereditary renal cell carcinoma: A single-institution study

Von Hippel-Lindau (VHL) disease is a genetic syndrome that involves the development of tumors in numerous organs. The kidney is one of the most frequently affected organs, and patients with VHL and renal tumors require repeated nephrectomy. The present study aimed to further determine the clinicopathological characteristics of patients with VHL-associated renal cell carcinoma (RCC), which may allow more rational clinical treatment decisions. This study included 27 patients with VHL who underwent radical or partial nephrectomy at the Peking University First Hospital between January 2010 and April 2018. The clinicopathological characteristics and prognosis of the patients were retrospectively reviewed. The expression of RCC-associated molecular markers was evaluated by immunohistochemistry. The mean size of the renal tumors was 4.3±2.0 cm (range 1.3–9.5 cm). The pathological type in 26 cases (96.3%) was clear cell RCC (CCRCC), whereas only one patient was diagnosed with CCRCC and clear cell papillary RCC. Renal cysts with a clear cell lining were observed, and RCC cell clusters were scattered in renal cyst cavities. Among the 27 patients, 21 (77.8%) were diagnosed with stage IA/T1N0M0, according to Tumor-Node-Metastasis staging, and 16 (59.3%) had grade 1 tumors. The mean postoperative follow-up duration was 39.0±24.0 months (range, 1.7–96.5 months). No metastasis or VHL-associated mortality was observed. VHL-associated RCC is a relatively low-risk disease, and a tumor size of 4 cm was determined as a threshold for nephron-sparing surgery. In addition, to prevent tumor cell dispersion, renal cysts should be carefully treated. A comprehensive understanding of the clinicopathological characteristics and underlying mechanisms of RCC associated with VHL syndrome may improve patient prognosis.
How Do Economic Growth, Urbanization, and Industrialization Affect Fine Particulate Matter Concentrations? An Assessment in Liaoning Province, China

With China’s rapid development, urban air pollution problems occur frequently. As one of the principal components of haze, fine particulate matter (PM2.5) has potential negative health effects, causing widespread concern. However, the causal interactions and dynamic relationships between socioeconomic factors and ambient air pollution are still unclear, especially in specific regions. As an important industrial base in Northeast China, Liaoning Province is a representative mode of social and economic development. Panel data including PM2.5 concentration and three socio-economic indicators of Liaoning Province from 2000 to 2015 were built. The data were first-difference stationary and the variables were cointegrated. The Granger causality test was used as the main method to test the causality. In the results, in terms of the causal interactions, economic activities, industrialization and urbanization processes all showed positive long-term impacts on changes of PM2.5 concentration. Economic growth and industrialization also significantly affected the variations in PM2.5 concentration in the short term. In terms of the contributions, industrialization contributed the most to the variations of PM2.5 concentration in the sixteen years, followed by economic growth. Though Liaoning Province, an industry-oriented region, has shown characteristics of economic and industrial transformation, policy makers still need to explore more targeted policies to address the regional air pollution issue.
Motor imagery and action observation for predictive control in developmental coordination disorder

In 2019, international clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder (DCD) were published. Informing our understanding of mechanisms, recent systematic reviews have shown that children with DCD have difficulties with the predictive control of movements, including aspects of motor planning, which is expressed as the internal modeling deficit hypothesis. This motor control deficit is most evident when the spatial and temporal demands of a task increase. An increasing number of empirical studies suggest that motor planning problems can be remediated through training based on one or a combination of motor imagery and action observation. In this review, we show evidence of motor planning problems in children with DCD and show that task demands or complexity affects its appearance. Implications of these findings are treatments based on motor imagery and action observation to remediate motor planning issues. The article concludes with recommendations for future research.
The Utility of Donor-specific Antibody Monitoring and the Role of Kidney Biopsy in Simultaneous Liver and Kidney Recipients With De Novo Donor-specific Antibodies

Background. There is limited information about the utility of donor-specific antibody (DSA) against HLA monitoring and the role of protocol kidney biopsy for de novo DSA (dnDSA) in simultaneous liver and kidney (SLK) transplant recipients. Methods. We analyzed SLK transplant recipients transplanted between January 2005 and December 2017, who had DSA checked posttransplant. Patients were divided into 2 groups based on whether they developed dnDSA posttransplant (dnDSA+) or not (dnDSA−). Kidney graft rejection ±45 d of dnDSA and a kidney death–censored graft survival were the primary endpoints. Results. A total of 83 SLK transplant recipients fulfilled our selection criteria. Of those, 23 were dnDSA+ and 60 were dnDSA−. Twenty-two of 23 dnDSA+ patients had DSA against class II HLA, predominantly against DQ. Fifteen recipients underwent kidney biopsy ±45 d of dnDSA. Six of these were clinically indicated due to kidney graft dysfunction. The other 9 had a protocol kidney biopsy only due to dnDSA, and 6 of these 9 had a rejection. Also, 3 recipients had sequential biopsies of both the kidney and liver grafts. Among those with sequential biopsies of both grafts, there was a difference between the organs in the rate and types of rejections. At last follow up, dnDSA was not associated with graft failure of either the kidney or liver. Conclusions. Although our study was limited by a small sample size, it suggests the potential utility of DSA monitoring and protocol kidney biopsy for dnDSA.
Impact of Pain Management Algorithm on Pain Intensity of Patients with Loss of Consciousness Hospitalized in Intensive Care Unit: A Clinical Trial

Background: Pain management programs in the case of patients with loss of consciousness could be advantageous inasmuch as they reduce the use of sedatives, prevent long hospitalization, and diminish the cost of treatment, medications, and hospitalization. Objectives: The present study aims to evaluate the effect of pain management algorithm on pain intensity in patients with loss of consciousness who had been hospitalized in an intensive care unit (ICU) in 2017. Methods: In this randomized single-blind clinical trial, 90 patients with loss of consciousness who were under mechanical ventilation and admitted to the ICU of Khatam al-Anbiya Hospital, Zahedan were chosen through convenience sampling. Using permuted block randomization, the subjects were then assigned into intervention and control groups. Pain management algorithm was implemented in the intervention group for 24 hours during the morning shift between 8 a.m. and 10 a.m., during the evening shift between 3 p.m. and 5 p.m. , and during the night shift between 10 p.m. and midnight. On the other hand, participants in the control group only received the routine care provided in the ward. Pain intensity was measured and recorded in both groups before and after the intervention. The tools used in this study included a demographic information form and the Behavioral Pain Scale (BPS). The data were analyzed in SPSS 15 using descriptive statistics, paired and independent t-tests, and chi-square. Results: There was no significant difference between the two groups in terms of gender, age, marital status, and the infused medications. The mean value of pain intensity in patients of the intervention group decreased after receiving the intervention for three shifts, and a significant difference was detected in the mean of this value before and after implementing the intervention. Conversely, the difference of the same variable in the control group was not significant before and after the intervention. In addition, the two groups significantly differed with regard to the mean changes of pain intensity during each of the three shifts (P < 0.001). Conclusions: Implementation of the pain management algorithm can significantly improve pain management in patients with loss of consciousness.
The Flavoproteome of the Model Plant Arabidopsis thaliana

Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are essential cofactors for enzymes, which catalyze a broad spectrum of vital reactions. This paper intends to compile all potential FAD/FMN-binding proteins encoded by the genome of Arabidopsis thaliana. Several computational approaches were applied to group the entire flavoproteome according to (i) different catalytic reactions in enzyme classes, (ii) the localization in subcellular compartments, (iii) different protein families and subclasses, and (iv) their classification to structural properties. Subsequently, the physiological significance of several of the larger flavoprotein families was highlighted. It is conclusive that plants, such as Arabidopsis thaliana, use many flavoenzymes for plant-specific and pivotal metabolic activities during development and for signal transduction pathways in response to biotic and abiotic stress. Thereby, often two up to several homologous genes are found encoding proteins with high protein similarity. It is proposed that these gene families for flavoproteins reflect presumably their need for differential transcriptional control or the expression of similar proteins with modified flavin-binding properties or catalytic activities.
HUBUNGAN PENGETAHUAN, SIKAP, DAN PERILAKU PENGGUNAAN ALAT PELINDUNG DIRI DENGAN KEJADIAN KECELAKAAN KERJA PADA TENAGA KERJA BANGUNAN DI PERUMAHAN HAJIMENA LAMPUNG SELATAN

Latar Belakang: Kecelakaan kerja di Indonesia pada tahun 2011-2015 tercatat 105.182 kasus dan mengalami peningkatan sekitar 5-10% tiap tahunnya. Dari data tersebut, 32% merupakan kecelakaan dibidang konstruksi bangunan. Kecelakaan kerja disebabkan sekitar 80% oleh unsafe acts, satu contohnya tidak menggunakan Alat Pelindung Diri (APD). Metode: Metode observasional dengan pendekatan cross sectional digunakan pada penelitian ini. Sampel penelitian adalah 62 tenaga kerja bangunan di Perumahan Hajimena Lampung Selatan, dengan metode consecutive sampling. Data penelitian ini dikumpulkan menggunakan kuesioner. Tes analisis menggunakan chi square test dan fisher test dengan CI 95% (α=5%). Hasil: Penelitian menunjukkan 75,8% pengetahuan responden, 90,3% sikap responden, dan 51,6% perilaku responden dalam penggunaan APD dan termasuk dalam katagori baik. Sedangkan kejadian kecelakaan kerja menunjukkan 62,9% dan termasuk dalam katagori tinggi. Tidak ada hubungan signifikan pengetahuan (p=0,729) dan sikap (p=0,393) penggunaan APD dengan kejadian kecelakaan kerja. Sedangkan ada hubungan signifikan perilaku penggunaan APD (p=0,03) dengan kejadiaan kecelakaan kerja. Simpulan: Terdapat hubungan perilaku penggunaan APD dengan kejadian kecelakaan kerja pada tenaga kerja bangunan di Perumahan Hajimena Lampung Selatan.Kata Kunci: Pengetahuan, Sikap, Perilaku, APD, Tenaga Kerja Bangunan, Kecelakaan Kerja.
Notes from the Field: Rebound in Routine Childhood Vaccine Administration Following Decline During the COVID-19 Pandemic — New York City, March 1–June 27, 2020

This article reported the decrease in the number of influenza vaccine doses administered in NYC during the COVID-19 pandemic The increase in vaccine administration seen in May and June is encouraging, and DOHMH continues to promote routine childhood vaccination using methods including public service announcements and letters, guidance, and webinars for health care providers on strategies to encourage parents to catch up their children's vaccinations
Genetic analysis of QTLs controlling allelopathic characteristics in sorghum

Mature sorghum herbage is known to contain several water-soluble secondary metabolites (allelochemicals). In this study, we investigated quantitative trait loci (QTLs) associated with allelochemical characteristics in sorghum using linkage mapping and linkage disequilibrium (LD)-based association mapping. A sorghum diversity research set (SDRS) of 107 accessions was used in LD mapping whereas, F2:3 lines derived from a cross between Japanese and African landraces were used in linkage mapping. The QTLs were further confirmed by positional (targeted) association mapping with Q+K model. The inhibitory effect of water-soluble extracts (WSE) was tested on germination and root length of lettuce seedlings in four concentrations (25%, 50%, 75% and 100%). A Significant range of variations was observed among genotypes in both types of mapping populations (P < 0.05). A total of 181 simple sequence repeats (SSRs) derived from antecedently reported map have been used for genotyping of SDRS. A genetic linkage map of 151 sorghum SSR markers was also developed on 134 F2 individuals. The total map length was 1359.3 cM, with an average distance of 8.2 cM between adjacent markers. LD mapping identified three QTLs for inhibition effect on germination and seven QTLs for root length of lettuce seedlings. Whereas, a total of six QTLs for inhibition of germination and ten QTLs for root length were detected in linkage mapping approach. The percent phenotypic variation explained by individual QTL ranged from 6.9% to 27.3% in SDRS and 9.9% to 35.6% in F2:3 lines. Regional association analysis identified four QTLs, three of them are common in other methods too. No QTL was identified in the region where major gene for sorgoleone (SOR1) has been cloned previously on chromosome 5.
Tuberculosis among Newly Arrived Immigrants and Refugees in the United States.

RATIONALE U.S. health departments routinely conduct post-arrival evaluation of immigrants and refugees at risk for tuberculosis, but this important intervention has not been thoroughly studied. OBJECTIVES To assess outcomes of the post-arrival evaluation intervention. METHODS We categorized at risk immigrants and refugees as: with recent completion of treatment for pulmonary tuberculosis disease overseas (including Mexico and Canada); with suspected tuberculosis disease (chest radiograph/clinical symptoms suggestive of tuberculosis) but negative cultures overseas; or with latent tuberculosis infection diagnosed overseas. Among 2.1 million US-bound immigrants and refugees screened for tuberculosis overseas during 2013-2016, 90,737 were identified as at risk for tuberculosis. We analyzed a national dataset of these at risk immigrants and refugees, and calculated rates of tuberculosis disease for those who completed post-arrival evaluation. RESULTS Among 4,225 persons with recent completion of treatment for pulmonary tuberculosis disease overseas, 3,005 (71.1%) completed post-arrival evaluation within 1 year of arrival; of these, 22 were diagnosed with tuberculosis disease (732 cases/100,000 persons): 4 sputum culture-positive cases (133 cases/100,000 persons), 13 sputum culture-negative cases (433 cases/100,000 persons), and 5 cases with no reported sputum culture results (166 cases/100,000 persons). Among 55,938 with suspected tuberculosis disease but negative cultures overseas, 37,089 (66.3%) completed post-arrival evaluation; of these, 597 were diagnosed with tuberculosis disease (1610 cases/100,000 persons): 262 sputum culture-positive cases (706 cases/100,000 persons), 281 sputum culture-negative cases (758 cases/100,000 persons), and 54 cases with no reported sputum culture results (146 cases/100,000 persons. Among 30,574 with latent tuberculosis infection diagnosed overseas, 18,466 (60.4%) completed post-arrival evaluation; of these, 48 were diagnosed with tuberculosis disease (260 cases/100,000 persons): 11 sputum culture-positive cases (60 cases/100,000 persons), 22 sputum culture-negative cases (119 cases/100,000 persons), and 15 cases with no reported sputum culture results (81 cases/100,000 persons). Of 21,714 persons for whom treatment for latent tuberculosis infection was recommended at post-arrival evaluation, 14,977 (69.0%) initiated and 8,695 (40.0%) completed treatment. CONCLUSIONS Post-arrival evaluation of at risk immigrants and refugees can be highly effective. To optimize yield and impact of this intervention, strategies are needed to improve completion rates of post-arrival evaluation and treatment for latent tuberculosis infection.
Investigation on the Status and Determinants of Caregiver Burden on Caring for Patients with Chronic Wound.

Objective: To investigate the caring burden and its determinants of primary informal caregiver of patients with chronic wound. Approach: A prospective cross-sectional study of 132 pairs of chronic wound care recipients and their informal caregivers was included. The characteristics of patients and their informal caregivers as well as caregiver burden assessment by the caregiver burden inventory (CBI) were measured. Single factor analysis and multiple regression analysis were carried out to explore the independent determinants of caregiver burden on caring for patients with chronic wound. Results: Most of the caregivers were female with mean age of 54.57 ± 13.35 years, and 58.3% of the caregivers were adult children. The mean CBI score was 34.21 ± 9.69 at a medium level. The following variables increased the CBI scores of caregivers: long caring time per day for patients, powerlessness status of patients, insufficient self-efficacy, and social support of caregivers, the model was able to explain 67.5% of variance in caregiver burden (F = 47.167, p = 0.000, R 2 = 0.675, adjusted R 2 = 0.660). Innovation: Caring burden of patients with chronic wound as a key consideration of patient-centered wound care has received relatively little attention. In this study we report the status of caring burden and reveal its determinants of primary informal caregiver of patients with chronic wound. Conclusion: Wound professionals are suggested to pay attention to the caregiver burden of patients with chronic wound and develop family-centered intervention support service system according to the determinants of caregiver burden to alleviate the caregiver burden.
Reversion‐inducing cysteine‐rich protein with Kazal motifs and MT1‐MMP promote the formation of robust fibrillin fibers

Fibrillins (FBNs) form mesh‐like structures of microfibrils in various elastic tissues. RECK and FBN1 are co‐expressed in many human tissues, suggesting a functional relationship. We found that dermal FBN1 fibers show atypical morphology in mice with reduced RECK expression (RECK‐Hypo mice). Dermal FBN1 fibers in mice‐lacking membrane‐type 1‐matrix metalloproteinase (MT1‐MMP) show a similar atypical morphology, despite the current notion that MT1‐MMP (a membrane‐bound protease) and RECK (a membrane‐bound protease inhibitor) have opposing functions. Our experiments using dermal fibroblasts indicated that RECK promotes pro‐MT1‐MMP activation, increases cell‐associated gelatinase/collagenase activity, and decreases diffusible gelatinase/collagenase activity, while MT1‐MMP stabilizes RECK in these cells. Experiments using purified proteins indicate that RECK and its binding partner ADAMTS10 keep the proteolytic activity of MT1‐MMP within a certain range. These findings suggest that RECK, ADAMTS10, and MT1‐MMP cooperate to support the formation of robust FBN1 fibers.