Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of intelligibility in dysarthria: development of a Maltese word and phrase list

ABSTRACT This paper describes the development of the Maltese Intelligibility Lists (MIL) for the assessment of word and phrase intelligibility in dysarthria. Two main tools were employed: the Frenchay Dysarthria Assessment-2 (FDA), and the Maltese Language Resource Server (MLRS). Three main criteria served as the basis for the construction of the word and phrase lists: frequency of occurrence of Maltese phonemes, word frequency and an analysis of syllable types and structures. The most common 500 words in the MLRS corpus (Korpus Malti v. 3) were broadly transcribed and an analysis of different types of syllables and their frequency of occurrence was carried out. Based on this analysis, the relevant proportion of different syllable types required for the word and phrase lists for Maltese was calculated in line with the number of items present in the FDA-2. With regards to phoneme frequency, the words chosen demonstrate a similar short-vowel and consonant distribution as reported in a previous large-scale study. The MIL consists of 116 words and 50 phrases which are representative of Standard Maltese and can be used in the clinic to assess speech intelligibility in Maltese individuals with dysarthria.
Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats

Background: The damage to intestinal barrier function plays an important role in the development of obesity and associated diseases. Soy isoflavones are effective natural active components for controlling obesity and reducing the level of blood lipid. Here, we explored whether these effects of soy isoflavones were associated with the intestinal barrier function. Methods and Results: The obese rat models were established by high fat diet feeding. Then, those obese rats were supplemented with soy isoflavones at different doses for 4 weeks. Our results showed that obesity induced the expressions of pro-inflammatory cytokines, decreased the anti-inflammatory cytokine (IL-10) expression, elevated intestinal permeability, altered gut microbiota and exacerbated oxidative damages in colon. The administration of soy isoflavones reversed these changes in obese rats, presenting as the improvement of intestinal immune function and permeability, attenuation of oxidative damage, increase in the fraction of beneficial bacteria producing short-chain fatty acids and short-chain fatty acid production, and reduction in harmful bacteria. Furthermore, soy isoflavones blocked the expressions of TLR4 and NF-κB in the colons of the obese rats. Conclusions: Soy isoflavones could improve obesity through the attenuation of intestinal oxidative stress, recovery of immune and mucosal barrier, as well as re-balance of intestinal gut microbiota.
Preparation, characterization and ex vivo–in vivo assessment of candesartan cilexetil nanocrystals via solid dispersion technique using an alkaline esterase activator carrier

Abstract The objective of this study was to improve candesartan cilexetil (CC) efficacy by formulating nanocrystals via solid dispersion (SD) technique using tromethamine (Tris). SD was prepared by solvent evaporation at different drug carrier ratios, evaluated for particle size, vitro dissolution studies, TEM, FTIR, and X-ray powder diffraction. Ex vivo, in vivo pharmacokinetic parameters were conducted on selected formulae compared to drug suspension and marketed product. Size analysis demonstrated formation of particles in the nanorange lower than 300 nm. A burst drug release followed by an improved dissolution was observed indicating instant formation of nanocrystals along with amorphization as confirmed by X-ray diffraction. FTIR studies suggested the absence of chemical interaction between Tris and CC. TEM revealed formation of irregular oval nanoparticles. SD-1:5 has higher apparent permeability coefficient compared to CC suspension. Furthermore, the pharmacokinetic results proved the ability of the formed nanoparticles to enhance the efficacy of CC compared to drug suspension and marketed product. In conclusion, using of Tris as alkaline esterase activator carrier could be a promising tool to bypass the controversial effect of esterase enzymes that may be a source for inter-individual variations affecting ester prodrug candidates’ efficacy.
The effects of stem cells on burn wounds: a review.

INTRODUCTION Stem cell therapy application is at the vanguard of regenerative medicine across all medical disciplines. Stem cells are of special interest in burn wounds, as they have multiple potential indications for application; including - accelerating wound healing, improving skin regeneration to incorporate skin appendages, reducing fibrosis and improving scarring. METHODS A literature review was performed using both MeSH and keyword searches of PubMed to identify all potentially suitable publications. Search criteria were restricted to the English language, but acceptable English translations were sought for inclusion. Inclusion dates were from 2003 up until and including 2017. Studies included looked at stem cells in burn wounds only. RESULTS There were 692 potentially suitable publications of which 72 were included for review. These included a systematic reviews and original research articles. CONCLUSIONS Stem cells accelerate burn wound healing by inducing neo-angiogenesis, collagen deposition and granulation tissue formation. They modulate the inflammatory response and reduce the risk of infection. They can regenerate skin appendages and halt he zone of stasis in acute burn injury. However with these pre-clinical animal model studies we must be cautious with our interpretation of this novel therapy.
Adult Asthma Diagnosis: Physician Reported Challenges in Alberta-Based Primary Care Practices

Introduction An estimated 8.1% of Canadians adults have asthma. While there are challenges associated with the use of objective measurement of lung function in the diagnosis of asthma, we are uncertain of the barriers that impact the use of objective measures, and have limited understanding of the challenges experienced by primary care providers in diagnosis of asthma. The objectives of this quality improvement initiative were to identify primary care providers’ methods of diagnosing asthma and to identify challenges with diagnosis. Methods An online survey was disseminated using a snowball methodology. Setting Primary care practices in Alberta, Canada. Participants A total of 84 primary care providers completed the survey. Main Outcome Measures Participants were asked their ideal and sufficient methods for diagnosing asthma and to identify challenges in their practice related to asthma diagnosis. Results They identified full pulmonary function testing (54%), pre- and postbronchodilator spirometry (54%), complete history and physical (42%), peak flow measurement overtime (26%), pulmonary consult (26%), and trial of asthma medication(s) (23%), as ideal methods of diagnosing asthma. The most significant barriers to diagnosis included episodic care–care provided typically during times of worsening symptoms without ongoing preventative/maintenance care (55%), patient follow-up (44%), conflict between clinical impression and pulmonary function results (43%), patient already on asthma medications (43%), and interpreting spirometry/pulmonary function results (39%). Conclusion The results of this survey indicate that the majority of primary care providers would choose full pulmonary function testing or pre- and postbronchodilator spirometry as the ideal methods of diagnosing asthma. However, barriers related to the nature of asthma care, patient factors, and challenges with diagnostic testing create challenges. This study also highlights that primary care providers have adapted to challenges in leveraging objective measurement and may rely upon other methods for diagnosis such as trials of medications.
Effects of two-year weather exposure on thermally modified Picea abies, Pinus sylvestris, and Fraxinus excelsior wood

The use of thermally modified timber (TMT) in outdoor applications is well established, but its performance against the stresses of outdoor conditions is not comprehensively understood. This study investigates the changes in density, surface chemical composition, color, equilibrium moisture content (EMC), checking, hardness, and cupping of thermally modified boards of Scots pine (Pinus sylvestris L.), Norway spruce (Picea abies (L.) H. Karst. ), and European ash (Fraxinus excelsior L.) during a two-year weather exposure test in Eastern Finland. Unmodified pine, spruce, and ash and copper salt impregnated pine boards were used as controls. The results show that a two-year weather exposure period causes degradation of hydrophobic lignin, and the leaching of the degraded compounds changed the color, increased the EMC, and decreased the hardness of specimens. Although the EMC of TMT specimens was lower compared with unmodified and impregnated ones during weathering, the changes were more obvious in TMT than in the controls. More checks occurred in the TMT specimens than in unmodified ones after the exposure. On the other hand, the TMT specimens had a lower degree of cupping. These findings also indicate that an increase in modification temperature induces more checks but improves the durability of all studied species by reducing the chemical degradation, color change, cupping, and hygroscopicity during weather exposure.
Robust Wasserstein profile inference and applications to machine learning

We show that several machine learning estimators, including square-root least absolute shrinkage and selection and regularized logistic regression, can be represented as solutions to distributionally robust optimization problems. The associated uncertainty regions are based on suitably defined Wasserstein distances. Hence, our representations allow us to view regularization as a result of introducing an artificial adversary that perturbs the empirical distribution to account for out-of-sample effects in loss estimation. In addition, we introduce RWPI (robust Wasserstein profile inference), a novel inference methodology which extends the use of methods inspired by empirical likelihood to the setting of optimal transport costs (of which Wasserstein distances are a particular case). We use RWPI to show how to optimally select the size of uncertainty regions, and as a consequence we are able to choose regularization parameters for these machine learning estimators without the use of cross validation. Numerical experiments are also given to validate our theoretical findings.
Effects of Maternal Singing Style on Mother–Infant Arousal and Behavior

Abstract Mothers around the world sing to infants, presumably to regulate their mood and arousal. Lullabies and playsongs differ stylistically and have distinctive goals. Mothers sing lullabies to soothe and calm infants and playsongs to engage and excite infants. In this study, mothers repeatedly sang Twinkle, Twinkle, Little Star to their infants (n = 30 dyads), alternating between soothing and playful renditions. Infant attention and mother–infant arousal (i.e., skin conductivity) were recorded continuously. During soothing renditions, mother and infant arousal decreased below initial levels as the singing progressed. During playful renditions, maternal and infant arousal remained stable. Moreover, infants exhibited greater attention to mother during playful renditions than during soothing renditions. Mothers' playful renditions were faster, higher in pitch, louder, and characterized by greater pulse clarity than their soothing renditions. Mothers also produced more energetic rhythmic movements during their playful renditions. These findings highlight the contrastive nature and consequences of lullabies and playsongs.
Diagnostic and prognostic benefit of arterial spin labeling in subacute stroke

Brain perfusion measurement in the subacute phase of stroke may support therapeutic decisions. We evaluated whether arterial spin labeling (ASL), a noninvasive perfusion imaging technique based on magnetic resonance imaging (MRI), adds diagnostic and prognostic benefit to diffusion‐weighted imaging (DWI) in subacute stroke.
Spin-orbital order in 
LaMnO3
: 
d−p
 model study

Using the multiband $d-p$ model and unrestricted Hartree-Fock approximation we investigate the electronic structure and spin-orbital order in three-dimensional MnO$_3$ lattice such as realized in LaMnO$_3$. The orbital order is induced and stabilized by particular checkerboard pattern of oxygen distortions arising from the Jahn-Teller effect in the presence of strong Coulomb interactions on $e_g$ orbitals of Mn ions. We show that the spin-orbital order can be modeled using a simple \textit{Ansatz} for local crystal fields alternating between two sublattices on Mn ions, which have non-equivalent neighboring oxygen distortions in $ab$ planes. The simple and computationally very inexpensive $d-p$ model reproduces correctly nontrivial spin-orbital order observed in undoped LaMnO$_3$. Orbital order is very robust and is reduced by $\sim 3$ \% for large self-doping in the metallic regime.
An empirical exploration of quality management practices and firm performance from Chinese manufacturing industry

In light of the growing demand for quality certifications, quality management practices have become crucial in the quest for profitability and market share. To date, the research into the firm performance of quality management is very limited. This paper aims to investigate the effects of quality management practices on the operational and financial performance. An event study methodology describing the year-to-year and cumulative effects of quality awards is developed. The data were collected from a sample of 148 Chinese manufacturing companies that won Chinese national and provincial quality awards. The results indicate that while quality award winners have advantages in terms of their profitability and operating efficiency, their sales growth is not improved as expected. In terms of innovation capability, award winners strongly underperform compared with their counterparts. This study also highlights that the positive impact on profitability may disappear after the certification and that the most significantly positive stimulus occurs in the certification year. This study provides evidence that quality certification cannot assure companies of competitive advantages. It also enlightens managers regarding the existence of obstacles from quality management systems to business performance.
Effects of Omega-3 Supplementation on Ki-67 and VEGF Expression Levels and Clinical Outcomes of Locally Advanced Breast Cancer Patients Treated with Neoadjuvant CAF Chemotherapy: A Randomized Controlled Trial Report

Background: Omega-3 is a polyunsaturated fatty acid with an ability to regulate cell proliferation and apoptosis through interaction with inflammatory mediators. The potential additional beneficial effects of Omega-3 on chemotherapy patients with breast cancer is not yet completely revealed. Methods: A double-blind randomized control trial (RCT) involving a total of 48 locally advanced breast cancer patients was conducted. Ki-67 and VEGF expressions, as well as overall survival of patients receiving neoadjuvant cyclophosphamide-doxorubicin-5’fluorouracyl (CAF) chemotherapy plus Omega-3 (intervention group) or placebo (control group), were compared. Kaplan-Meier curve and Cox-regression tests were used to assess conditional disease-free survival (DFS) and overall survival (OS) between the two groups. Results: Decreased Ki-67 expression was observed in the intervention group compared to control (42.4±4.8 versus 39.2±5.3; T-test p=0.032). Decreased Ki-67 expression was observed in intervention compared to control group (42.4±4.8 versus 39.2±5.3; T-test p=0.032). Decreased VEGF expression was also seen in the intervention group compared to control (32.7±5.2 versus 29.5±5.4; T-test p=0.041). VEGF expression positively correlated with Ki-67 expression (Spearman’s test p<0.001, R2=0.541). Overall survival in the intervention group was significantly longer in comparison to the control group (mean survival: 30.9 ± 3.71 versus 25.9 ± 3.6 weeks, Mantel-Cox test p=0.048; HR=0.411, 95%CI: 0.201-0.840). Disease-free survival was significantly longer in the intervention group compared to the control group (mean survival: 28.5 ± 3.3 versus 23.7 ± 3.6, respectively; Mantel-Cox test p=0.044, HR= 0.439, 95%CI: 0.222-0.869). Conclusion: Omega-3 fatty acid supplementation improved overall survival and progression-free survival of locally advanced breast cancer treated with CAF neoadjuvant chemotherapy and mastectomy.
Populist parties and foreign policy: The case of Italy’s Five Star Movement

The role of political parties in foreign policy is gaining increasing attention. Nonetheless, despite an extraordinary interest in ‘populism’, the foreign policy of populist parties has rarely been investigated. This article provides an innovative theoretical framework, applying it on a rare example of a ‘pure’ populist party: Italy’s Five Star Movement. How has Five Star Movement positioned on Italian contribution to military operations abroad? What does such positioning say about its ideological leaning? In order to address such questions, the article analyses Five Star Movement’s MPs’ votes and speeches on foreign policy during its first term in Parliament (2013–2018). We find that, notwithstanding some ambiguities, the Movement’s stance has been mostly pacifist and humanitarian, resembling more a ‘left-libertarian populist party’ than a ‘sovereigntist far-right one’. Through these findings, the article contributes to the debate on populist parties and foreign policy in Europe, clarifying also the elusive ideological leaning of the Five Star Movement.
Measurement of the Dynamics of the Decays D_{s}^{+}→η^{(')}e^{+}ν_{e}.

Using e^{+}e^{-} annihilation data corresponding to an integrated luminosity of 3.19 fb^{-1} collected at a center-of-mass energy of 4.178 GeV with the BESIII detector, we measure the absolute branching fractions B_{D_{s}^{+}→ηe^{+}ν_{e}}=(2.323±0.063_{stat}±0.063_{syst})% and B_{D_{s}^{+}→η^{'}e^{+}ν_{e}}=(0.824±0.073_{stat}±0.027_{syst})% via a tagged analysis technique, where one D_{s} is fully reconstructed in a hadronic mode. Combining these measurements with previous BESIII measurements of B_{D^{+}→η^{(')}e^{+}ν_{e}}, the η-η^{'} mixing angle in the quark flavor basis is determined to be ϕ_{P}=(40.1±2.1_{stat}±0.7_{syst})°. From the first measurements of the dynamics of D_{s}^{+}→η^{(')}e^{+}ν_{e} decays, the products of the hadronic form factors f_{+}^{η^{(')}}(0) and the Cabibbo-Kobayashi-Maskawa matrix element |V_{cs}| are determined with different form factor parametrizations. For the two-parameter series expansion, the results are f_{+}^{η}(0)|V_{cs}|=0.4455±0. 0053_{stat}±0. 0044_{syst} and f_{+}^{η^{'}}(0)|V_{cs}|=0.477±0. 049_{stat}±0. 011_{syst}.
Extreme Debris Disk Variability: Exploring the Diverse Outcomes of Large Asteroid Impacts During the Era of Terrestrial Planet Formation

The most dramatic phases of terrestrial planet formation are thought to be oligarchic and chaotic growth, on timescales of up to 100–200 Myr, when violent impacts occur between large planetesimals of sizes up to protoplanets. Such events are marked by the production of large amounts of debris, as has been observed in some exceptionally bright and young debris disks (termed extreme debris disks). Here we report five years of Spitzer measurements of such systems around two young solar-type stars: ID8 and P1121. The short-term (weekly to monthly) and long-term (yearly) disk variability is consistent with the aftermaths of large impacts involving large asteroid-sized bodies. We demonstrate that an impact-produced clump of optically thick dust, under the influence of the dynamical and viewing geometry effects, can produce short-term modulation in the disk light curves. The long-term disk flux variation is related to the collisional evolution within the impact-produced fragments once released into a circumstellar orbit. The time-variable behavior observed in the P1121 system is consistent with a hypervelocity impact prior to 2012 that produced vapor condensates as the dominant impact product. Two distinct short-term modulations in the ID8 system suggest two violent impacts at different times and locations. Its long-term variation is consistent with the collisional evolution of two different populations of impact-produced debris dominated by either vapor condensates or escaping boulders. The bright, variable emission from the dust produced in large impacts from extreme debris disks provides a unique opportunity to study violent events during the era of terrestrial planet formation.
Frames for the Solution of Operator Equations in Hilbert Spaces with Fixed Dual Pairing

Abstract For the solution of operator equations, Stevenson introduced a definition of frames, where a Hilbert space and its dual are not identified. This means that the Riesz isomorphism is not used as an identification, which, for example, does not make sense for the Sobolev spaces and . In this article, we are going to revisit the concept of Stevenson frames and introduce it for Banach spaces. This is equivalent to -Banach frames. It is known that, if such a system exists, by defining a new inner product and using the Riesz isomorphism, the Banach space is isomorphic to a Hilbert space. In this article, we deal with the contrasting setting, where and are not identified, and equivalent norms are distinguished, and show that in this setting the investigation of -Banach frames make sense.
What Determines the X-Ray Intensity and Duration of a Solar Flare?

Solar flares are observed and classified according to their intensity measured with the Geostationary Operational Environmental Satellite (GOES) X-ray Sensors. We show that the duration of a flare, as measured by the full width at half maximum (FWHM) in GOES is not related to the size of the flare as measured by GOES intensity. The durations of X-class flares range from a few minutes to a few hours, and the same is true of M- and C-class flares. In this work, we therefore examine the statistical relationships between the basic properties of flares—temperature, emission measure, energy, etc.—in comparison to both their size and duration. We find that the size of the flare is directly related to all of these basic properties, as previously found by many authors. The duration is not so clear. When examining the whole data set, the duration appears to be independent of all of these properties. In larger flares, however, there are direct correlations between the GOES FWHM and magnetic reconnection flux and ribbon area. We discuss the possible explanations, finding that this discrepancy may be due to large uncertainties in small flares, though we cannot rule out the possibility that the driving physical processes are different in smaller flares than larger ones. We discuss the implications of this result and how it relates to the magnetic reconnection process that releases energy in flares.
The impact of free trade agreements on FDI inflows: the case of Vietnam

Abstract We examine the relationship between FTAs and inward FDI in Vietnam using panel data for Vietnam’s 17 main foreign investors over the period 1997–2016, and 23 partners for the sub-period 2005–2016. In contrast to past studies that focus on either multiple FTAs for a group of countries or case studies for a well-known FTA, we evaluate whether the overall involvement in FTAs of a developing country such as Vietnam increases FDI inflows. Results from gravity models strongly indicate that FTAs, overall, are associated with increased FDI inflows, with a much greater impact in the sub-period. We also find evidence of the prevalence of vertical FDI in Vietnam. Further examination of the later sub-period shows that FTAs also have a significant effect on inward FDI through interactions with the real exchange rate, human capital, and factor endowments. Interestingly, all of the three FDI determinants have more important roles following the FTAs.