Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing Spatial Limits of Sentinel-2 Data on Arable Crops in the Context of Checks by Monitoring

The availability of large amounts of Sentinel-2 data has been a trigger for its increasing exploitation in various types of applications. It is, therefore, of importance to understand the limits above which these data still guarantee a meaningful outcome. This paper proposes a new method to quantify and specify restrictions of the Sentinel-2 imagery in the context of checks by monitoring, a newly introduced control approach within the European Common Agriculture Policy framework. The method consists of a comparison of normalized difference vegetation index (NDVI) time series constructed from data of different spatial resolution to estimate the performance and limits of the coarser one. Using similarity assessment of Sentinel-2 (10 m pixel size) and PlanetScope (3 m pixel size) NDVI time series, it was estimated that for 10% out of 867 fields less than 0.5 ha in size, Sentinel-2 data did not provide reliable evidence of the activity or state of the agriculture field over a given timeframe. Statistical analysis revealed that the number of clean or full pixels and the proportion of pixels lost after an application of a 5-m (1/2 pixel) negative buffer are the geospatial parameters of the field that have the highest influence on the ability of the Sentinel-2 data to qualify the field’s state in time. We specified the following limiting criteria: at least 8 full pixels inside a border and less than 60% of pixels lost. It was concluded that compliance with the criteria still assures a high level of extracted information reliability. Our research proved the promising potential, which was higher than anticipated, of Sentinel-2 data for the continuous state assessment of small fields. The method could be applied to other sensors and indicators.
Data challenges in variational optical flow

The estimation of the motion between consecutive images of a scene – the so-called optical flow – is a key problem in computer vision. Unfortunately, such consecutive images can expose severe data challenges for this estimation including large displacements due to temporal undersampling of the image sequence or illumination changes that are the outcome of changing lighting conditions. In this thesis, we address these challenges by improving variational methods which have a successful history and allow for a transparent modeling: (i) We propose a robust integration of external feature matches into variational methods. While feature matching is inherently able to estimate large displacements, it is at the same time sensitive to false correspondences due to lacking regularization. (ii) As an alternative, we develop an extended variational method that is able to estimate large displacements with inherent regularization. This allows to handle many large displacement scenarios while not being sensitive to unconstrained false matches. The potential of such methods to handle these cases is widely underestimated in the literature. (iii) In the context of illumination changes, we learn parametrizations to capture the types of these changes and introduce a variational method that can jointly estimate their magnitudes alongwith the optical flow. This joint estimation provides robustness against such changes without discarding essential image information. (iv) We combine the most promising concepts of each of the prior methods, i.e. determining illumination changes, estimating regularized motion candidates for large displacements and integrating them robustly into the final optical flow estimation. This leads to a pipeline of variational methods that allows us to robustly handle large displacements even in the presence of illumination changes. (v)We embed all the involved data terms, which are responsible for handling any data within the process of variational motion estimation, into a common notational framework based on the well-known motion tensor notation. This notation not only allows for an easy integration of all of the presented concepts into variational frameworks, it also forms the basis for the integration of further recent concepts such as trajectorial regularization terms. The results of all these improved variational methods demonstrate the benefits of the aforementioned strategies and show clear advances over prior works.
Bone Mineral Density in Adults With Congenital Adrenal Hyperplasia: A Systematic Review and Meta-Analysis

Background: Decreased bone mineral density (BMD) is a concern in patients with congenital adrenal hyperplasia (CAH) due to lifelong glucocorticoid replacement. Studies till date have yielded conflicting results. We wanted to systematically evaluate the available evidence regarding BMD in adult patients with CAH. Methods: We searched Medline, Embase and Cochrane Central Register of Controlled Trials to identify eligible studies. Studies comparing BMD in CAH patients with age- and sex-matched controls were included. Age <16 years and absence of controls were exclusion criteria. Two authors independently reviewed abstracts, read full-text articles, extracted data, assessed risk of bias using Newcastle-Ottawa scale, and determined level of evidence using Grading of Recommendations Assessment, Development, and Evaluation methodology. Results: Nine case-control studies with a total sample of 598 (cases n = 254, controls n = 344) met eligibility criteria. Median age was 31 years (IQR 23.9–37) and 65.7% were female. Total body BMD (Mean Difference [MD]-0.06; 95%CI −0.07, −0.04), lumbar spine BMD (MD −0.05; 95%CI −0.07, −0.03) and femoral neck BMD (MD −0.07; 95%CI −0.10, −0.05) was lower in cases compared to controls. Lumbar spine T-scores (MD −0.86; 95%CI −1.16, −0.56) and Z-scores (MD −0.66; 95%CI −0.99, −0.32) and femoral neck T-scores (MD −0.75 95%CI −0.95, −0.56) and Z-scores (MD −0.27 95%CI −0.58, 0.04) were lower in cases. Conclusion: BMD in adult patients with CAH was lower compared to controls. Although insufficient data precludes a dose-response relationship between glucocorticoid dose and BMD, it would be prudent to avoid overtreatment with glucocorticoids.
Exploring the Role of Action Consequences in the Handle-Response Compatibility Effect

Previous research investigating handle-response compatibility effects with graspable objects used different categories of objects as stimuli, regardless of their specific, intrinsic characteristics. The current study explores whether different types of objects’ characteristics may elicit different types of spatial compatibility, that is, handle-response and response-effect compatibility as well as their potential interaction. In Experiment 1, objects having a graspable handle opposite to either a visible functional component (i.e., handle-function objects: a teapot) or a latent functional component (handle-only objects: a pitcher lacking the spout) were presented separately in different blocks. Both the handle and the goal-directed functional components of these objects were located on the horizontal axis. In Experiment 2, handle-only objects had a handle located on the horizontal axis and a latent functional component located on the vertical axis (e.g., a cup). In both experiments, participants were required to judge the material (plastic and metal) the object was made of. Results showed that the handle-response compatibility effect was sensitive to whether the actions consequences of object manipulation took place on the horizontal rather than on the vertical axis.
Repetitive Transcranial Magnetic Stimulation Improves Amygdale Functional Connectivity in Major Depressive Disorder

Emotional abnormality in major depressive disorder (MDD) is generally regarded to be associated with functional dysregulation in the affective network (AN). The present study examined the changes in characteristics of AN connectivity of MDD patients before and after repetitive transcranial magnetic stimulation (rTMS) treatment over the left dorsolateral prefrontal cortex, and to further assess how these connectivity changes are linked to clinical characteristics of patients. Functional connectivity (FC) in the AN defined by placing seeds in the bilateral amygdale was calculated in 20 patients with MDD before and after rTMS, and in 20 healthy controls (CN). Furthermore, a linear regression model was used to obtain correlations between FC changes and Hamilton depression scale (HAMD) changes in MDD before and after rTMS. Before rTMS, compared with CN, MDD exhibited significantly lower FC between left insula (INS.L), right superior and inferior frontal gyrus (SFG.R and IFG.R), right inferior parietal lobule (IPL.R), and amygdala, and showed an increment of FC between the bilateral precuneus and amygdala in AN. After rTMS, MDD exhibited a significant increase in FC in the INS.L, IFG.R, SFG.R, IPL.R, and a significant reduction in FC in the precuneus. Interestingly, change in FC between INS.L and left amygdala was positively correlated with change in HAMD scores before and after rTMS treatment. rTMS can enhance affective network connectivity in MDD patients, which is linked to emotional improvement. This study further suggests that the insula may be a potential target region of clinical efficacy for MDD to design rationale strategies for therapeutic trials.
Microbiomes and Specific Symbionts of Social Spiders: Compositional Patterns in Host Species, Populations, and Nests

Social spiders have remarkably low species-wide genetic diversities, potentially increasing the relative importance of microbial symbionts for host fitness. Here we explore the bacterial microbiomes of three species of social Stegodyphus (S. dumicola, S. mimosarum, and S. sarasinorum), within and between populations, using 16S rRNA gene amplicon sequencing. The microbiomes of the three spider species were distinct but shared similarities in membership and structure. This included low overall diversity (Shannon index 0.5–1.7), strong dominance of single symbionts in individual spiders (McNaughton’s dominance index 0.68–0.93), and a core microbiome (>50% prevalence) consisting of 5–7 specific symbionts. The most abundant and prevalent symbionts were classified as Chlamydiales, Borrelia, and Mycoplasma, all representing novel, presumably Stegodyphus-specific lineages. Borrelia- and Mycoplasma-like symbionts were localized by fluorescence in situ hybridization (FISH) in the spider midgut. The microbiomes of individual spiders were highly similar within nests but often very different between nests from the same population, with only the microbiome of S. sarasinorum consistently reflecting host population structure. The weak population pattern in microbiome composition renders microbiome-facilitated local adaptation unlikely. However, the retention of specific symbionts across populations and species may indicate a recurrent acquisition from environmental vectors or an essential symbiotic contribution to spider phenotype.
Influence of Reward Motivation on Directed Forgetting in Younger and Older Adults

An important feature of the memory system is the ability to forget, but aging is associated with declines in the ability to intentionally forget potentially due to declines in cognitive control. Despite cognitive deficits, older adults are sensitive to affective manipulations, such as reward motivation, and reward anticipation can improve older adults’ memory performance. The goal of the current studies was to examine the effect of reward motivation on directed remembering and forgetting. Participants were healthy CloudResearch/Turk Prime workers aged 18–35 and 60–85. In Experiment 1, we conducted a typical item-method directed forgetting task using neutral words presented one at a time followed by a to-be-remembered (TBR) or to-be-forgotten (TBF) cue. A recognition memory test followed that included all words from the encoding task, as well as new words. We replicated prior findings of better memory for TBR compared to TBF items, but not typical age-related differences in recognition of TBF items. In Experiments 2–4, we repeated this paradigm except that in the second block of trials, each word was presented with a high ($0.75) or low ($0.01) reward cue indicating the value that could be earned if the item was successfully Remembered or Forgotten (depending on cue). During recognition, correct responses to target items (both TBR and TBF) resulted in the associated reward, but incorrect “old” responses resulted in a loss of $0.50. In three experiments, high rewards led to better memory for younger and older adults compared to low rewards, regardless of the directed cue to remember or forget the word. In Experiments 3 and 4, older adults showed typical deficits in directed forgetting, but this was across reward conditions. For older adults, there was no evidence that including reward motivation improved cognitive control abilities as high value reward anticipation did not improve directed forgetting. Instead, in line with hypotheses, high compared to low value reward anticipation leads to engagement of processes that result in better memory regardless of the TBR or TBF cue, and reward anticipation bolsters memory in a relatively automatic, rather than strategic, fashion that overrides one’s ability to cognitively control encoding processes.
A New Cage-Like Particle Adjuvant Enhances Protection of Foot-and-Mouth Disease Vaccine

Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model to predict their effectiveness in cattle. Immunostimulant Particle Adjuvant (ISPA), also known as cage-like particle adjuvant, consisting of lipid boxes of dipalmitoyl-phosphatidylcholine, cholesterol, sterylamine, alpha-tocopherol, and QuilA saponin, was shown to enhance protection of a recombinant vaccine against Trypanosoma cruzi in a mouse model. Thus, in the present work, we studied the effects on the magnitude and type of immunity elicited in mice and cattle in response to a vaccine based on inactivated FMD virus (iFMDV) formulated with ISPA. It was demonstrated that iFMDV–ISPA induced protection in mice against challenge and elicited a specific antibody response in sera, characterized by a balanced Th1/Th2 profile. In cattle, the antibody titers reached corresponded to an expected percentage of protection (EPP) higher than 80%. EPP calculates the probability that livestock would be protected against a 10,000 bovine infectious doses challenge after vaccination. Moreover, in comparison with the non-adjuvanted iFMDV vaccine, iFMDV–ISPA elicited an increased specific T-cell response against the virus, including higher interferon gamma (IFNγ)+/CD8+ lymphocyte production in cattle. In this work, we report for first time that an inactivated FMDV serotype A vaccine adjuvanted with ISPA is capable of inducing protection against challenge in a murine model and of improving the specific immune responses against the virus in cattle.
Assisting Decision-Making on Age of Neutering for Mixed Breed Dogs of Five Weight Categories: Associated Joint Disorders and Cancers

The early neutering of male and female dogs and its relationship to an increased risk of joint disorders and some cancers has recently become a concern, raising questions about the standard practice in the U.S. and much of Europe of neutering by 6 months of age. A noteworthy recent finding from this center is that there are major breed differences with small-dog breeds generally showing little vulnerability to neutering compared with breeds of larger body size. These findings on purebreds raise questions for dog owners and veterinarians about mixed-breed dogs. The purpose of this study was to examine a sample of mixed breed dogs of five weight categories using the same veterinary hospital database and diagnostic criteria for joint disorders and cancers as used in the newly published paper on 35 breeds and previous papers on the Golden Retriever, Labrador Retriever, and German Shepherd Dog. The weight categories were <10 kg (739 cases), 10–19 kg (546 cases), 20–29 kg (992 cases), 30–39 kg (604 cases), and over 40 kg (258 cases). Males and females were analyzed separately, as were various ages at neutering. The joint disorders examined were hip dysplasia, cranial cruciate ligament tear or rupture, and elbow dysplasia. The cancers were lymphoma, mast cell tumor, hemangiosarcoma, and osteosarcoma. There was no significant increased occurrence of one or more cancers, compared with intact dogs, in any weight category. However, in the three categories of dogs weighing 20 kg or more, neutering before 1 year generally was significantly associated with risks of one or more joint disorders above that of dogs left intact, commonly to 3 times the level of intact dogs, with sex differences in the degrees of joint disorders associated with neutering. For the dogs in the two weight categories <20 kg, no increased risks were found for joint disorders. This information can be useful to dog caregivers in deciding on the age at which to neuter specific dogs, and for veterinarians offering guidance to pet owners.
Environmental Orderliness Affects Self-Control and Creative Thinking: The Moderating Effects of Trait Self-Control

Environmental orderliness can affect both self-control behaviors and creative thinking; however, little research has focused on the moderators of this effect. In this study, we investigated the moderating effect of trait self-control on environmental orderliness, which influences both state self-control behaviors and creative thinking. In Experiment 1, we explored whether trait self-control could moderate the effect of environmental orderliness on state behavioral self-control. The participants have been exposed to an orderly or a disorderly room and asked to complete a breath-holding task to measure self-control. The results showed that low trait self-control participants were more self-controlled in the orderly environment, whereas the self-control of those with high trait self-control was not affected by environmental orderliness. In Experiment 2, the moderating effect of trait self-control on environmental orderliness affecting creative thinking was investigated with a picture priming orderliness and the Alternative Uses Test. As expected, the participants with high trait self-control in the disorderly environment had better creative thinking performance, although there was no difference in the performance of those with low trait self-control between the two environmental orderliness conditions. The results demonstrated that trait self-control could moderate the dual effect of environmental orderliness. The present study sheds light on the effect of environmental orderliness and contributes to the understanding of the common mechanism of the dual effect; also, it has practical implications for the shaping and cultivation of individuals' self-control behaviors and creative thinking.
Evaluating Thymic Function After Human Hematopoietic Stem Cell Transplantation in the Personalized Medicine Era

Hematopoietic stem cell transplantation (HSCT) is an effective treatment option for several malignant and non-malignant hematological diseases. The clinical outcome of this procedure relies to a large extent on optimal recovery of adaptive immunity. In this regard, the thymus plays a central role as the primary site for de novo generation of functional, diverse, and immunocompetent T-lymphocytes. The thymus is exquisitely sensitive to several insults during HSCT, including conditioning drugs, corticosteroids, infections, and graft-vs.-host disease. Impaired thymic recovery has been clearly associated with increased risk of opportunistic infections and poor clinical outcomes in HSCT recipients. Therefore, better understanding of thymic function can provide valuable information for improving HSCT outcomes. Recent data have shown that, besides gender and age, a specific single-nucleotide polymorphism affects thymopoiesis and may also influence thymic output post-HSCT, suggesting that the time of precision medicine of thymic function has arrived. Here, we review the current knowledge about thymic role in HSCT and the recent work of genetic control of human thymopoiesis. We also discuss different transplant-related factors that have been associated with impaired thymic recovery and the use of T-cell receptor excision circles (TREC) to assess thymic output, including its clinical significance. Finally, we present therapeutic strategies that could boost thymic recovery post-HSCT.
Validation of Global Self-Rated Health and Happiness Measures Among Older People in the Yilan Study, Taiwan

Background: Single-item measures of physical and mental health are feasible for older adults, but their validity for that age group is unclear. This study tested validity of a global self-rated health and a global self-rated happiness measure in a large sample of community-dwelling older adults in Taiwan. Methods: A cross-sectional sample of 3,982 men and women aged 65 or older in Yilan, Taiwan, provided data on global self-rated health and happiness using 100-point numerical scales. The Physical Component Summary of the 12-Item Short Form Health Survey (version 2) and the Groningen Activity Restriction Scale were used to test the validity of the self-rated health item. The Mental Component of that 12-item scale and the Hospital Anxiety and Depression Scale were validators regarding the self-rated happiness item. Criterion validity was tested using the 12-Item Short Form Health Survey (version 2). Results: The correlations between the self-rated health and happiness measures and the 12-Item Short Form Health Survey (version 2) validators were positive and statistically significant, supporting convergent validity. Sufficient divergent validity was demonstrated through the negative and significant relationship between the self-rated health item and the Groningen Activity Restriction Scale scores and the negative and significant relationship between the self-rated happiness item and the Hospital Anxiety and Depression Scale. Optimal cut-off scores for physical and mental health states depended on age and gender. Conclusion: The global self-rated health and happiness measures were validated. Cut-off scores for evaluating older adults' physical and mental health should be age- and gender-specific.
Reciprocal Substitution Between Methamphetamine and Heroin in Terms of Reinforcement Effects in Rats

Heroin and methamphetamine are both popular illicit drugs in China. Previous clinical data showed that habitual users of either heroin or methamphetamine abuse the other drug for substitution in case of unavailability of their preferred drug. The present study aimed to observe whether heroin can substitute the methamphetamine reinforcement effect in rats, and vice versa. Rats were trained to self-administer heroin or methamphetamine (both 50 μg/kg/infusion) under an FR1 reinforcing schedule for 10 days. After having extracted the dose–effect curve of the two drugs, we administered methamphetamine at different doses (12.5–200 μg/kg/infusion) to replace heroin during the period of self-administration, and vice versa. The heroin dose–effect curve showed an inverted U-shaped trend, and the total intake dose of heroin significantly increased when the training dose increased from 50 to 100 or 200 μg/kg/infusion. Following replacement with methamphetamine, the total dose–effect curve shifted leftwards and upwards. By contrast, although the dose–effect curve of methamphetamine also showed an inverted U-shaped trend, the total dose of methamphetamine significantly decreased when the training dose decreased from 50 to 25 μg/kg/infusion; conversely, when the methamphetamine training dose increased, the total dose did not change significantly. The total dose–effect curve shifted rightwards after heroin was substituted with methamphetamine. Although heroin and methamphetamine had their own independent reward effects, low doses of methamphetamine can replace the heroin reward effect, while high doses of heroin can replace the methamphetamine reward effect. These results demonstrated that heroin and methamphetamine can substitute each other in terms of reinforcement effects in rats.