Miracle-dz/UniFAR-FTUs huggingface dataset:
What is known about deferasirox chelation therapy in pediatric HsCT recipients: two case reports of metabolic acidosis

: To date, in pediatric field, various hematological malignancies are increasingly treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Iron overload and systemic siderosis often occur in this particular cohort of patients and are associated with poor prognosis. We describe herein the case of two allo-HSCT patients, on treatment with deferasirox; they showed histopathological elements compatible with venoocclusive disease or vanishing bile duct syndrome in ductopenic evolution before deferasirox started. The first patient developed drug-induced liver damage with metabolic acidosis and the second one a liver impairment with Fanconi syndrome. After withdrawing deferasirox treatment, both patients showed improvement. Measurements of drug plasma concentrations were performed by HPLC assay. The reduction and consequent disappearance of symptoms after the suspension of deferasirox substantiate its role in inducing hepatic damage, probably enabling the diagnosis of drug-induced liver damage. But the difficulties in diagnosing drug-related toxicity must be underlined, especially in compromised subjects. For these reasons, in patients requiring iron-chelating therapy, close and careful drug therapeutic monitoring is strongly recommended.
Structure and SHRIMP U/Pb Zircon ages of granites adjacent to the Chitradurga schist belt: implications for Neoarchaean convergence in the Dharwar craton, Southern India

Neoarchaean granites adjacent to the Chitradurga schist belt were emplaced in the inner margin of the foreland in the context of the Neoarchaean oblique convergent setting of the Dharwar craton. Two previously unreported granites, one 50 km and the other 80 km NW of Chitradurga town, and a mylonitised granite in the hanging wall of a duplex in the NW of the schist belt yielded SHRIMP U/Pb zircon emplacement ages of 2648±40 Ma, 2598±19 Ma, and ca. 2600 Ma, respectively, the large errors being due to radiogenic Pb loss during an unidentified Neoproterozoic event. Some discrete zircon grains and xenocrystic cores yielded ≥3000 Ma ages that were derived from older rocks during anatexis or emplacement. The granites NW of Chitradurga town were emplaced as steep sheets trending NW·SE. The Chitradurga granite has a similar form, bifurcating N of Chitradurga town into two separate, steeply dipping, NW-SE sheets. Magmatic-and solid-state fabrics in these granites show that emplacement took place during, but was outlasted by, sinistral and dextral strike-Parallel shear. Emplacement of the granite above the hanging wall of the duplex in the NW of the schist belt was outlasted by top-SW displacement. The shapes of the granites and their emplacement in relation to the structure of the Ranibennur and Chitradurga schist belts in the west of the craton are modelled as a mid-Crustal part of a craton-Wide imbricate fold-Thrust belt. The relationships show that whereas some Neoarchaean granites in the craton were emplaced prior to, or during, SW-vergent thrust thickening, most granites and related plutonic suites in the foreland and accretionary complex were emplaced later as multipulse injections in steep NW-SE sheets or wedges during orogen-parallel. sinistral and dextral shear. Steep highstrain zones in the foreland and accretionary complex are interpreted as listric structures that root into an attachment at a depth of ca. 18-20km in accord with the depth of the boundary between upper and lower crust placed at ca. 23 km from seismic reflection data published in 1979 and in more recent studies. The new structural observations and zircon dating, combined with published isotopic age data, show that the inner margin of the foreland in the west of the craton and the outer margin of the accretionary complex in the east are linked in a diffuse, steeply dipping, Orogen-parallel boundary zone at least 200 km wide.
Insertion / Deletion Polymorphism of Angiotensin Converting Enzyme Gene Does Not Contribute to Chronic Kidney Disease in Palestine

1Department of Medical Biology and Genetics, Institute of Health Sciences, Near East University, Nicosia, Turkish Republic of Northern Cyprus 2Medical Laboratory Sciences Department, University College of Sciences and Technology, Gaza Strip, Palestine 3Department of Medical Biology Genetics, Faculty of Medicine, Near East University, Nicosia, Turkish Republic of Northern Cyprus 4Department of Molecular Biology and Genetics, Faculty of Art and Sciences, Near East University, Nicosia, Turkish Republic of Northern Cyprus
EFEKTIFITAS PIJAT BAYI TERHADAP PENINGKATAN BERAT BADAN BAYI PREMATUR DI RUANG PERINATOLOGI RUMAH SAKIT IMELDA MEDAN

Pijat bayi adalah terapi sentuh tertua yang dikenal manusia yang paling populer. Pijat bayi telah lama dilakukan hampir diseluruh dunia, termasuk di Indonesia, dan diwariskan secara turun temurun. Salah satu manfaat pijat bayi adalah meningkatkan berat badan bayi prematur. Menurut penelitian T.Field dan Scafidi (1986 dan 1990) menunjukkan bahwa pada 20 bayi prematur (berat badan 1.280 dan 1.176 gr), yang dipijat selama 3 kali 15 menit selama 10 hari, terjadi kenaikan berat badan 20% - 47% per hari, lebih dari yang tidak dipijat. Tujuan penelitian ini adalah untuk mengidentifikasi efektifitas pijat bayi terhadap peningkatan berat badan bayi prematur. Penelitian ini menggunakan desain quasieksperimen. Jumlah sampel dalam penelitian ini adalah 35 orang pada kelompok intervensidan 35 orang pada kelompok kontrol. Pengambilan sampel dilakukan dengan menggunakan purposive sampling. Penelitian ini dilakukan di Ruang Perinatologi Rumah Sakit ImeldaMedan. Analisa data digunakan uji t-dependent dan uji t-independent. Hasil uji t-dependent disimpulkan ada perbedaan yang signifikan pada berat badan bayi prematur sebelum dan sesudah dilakukan pemijatan pada kelompok intervensi (nilai p= 0.000). Pada kelompok kontrol disimpulkan ada perbedaan yang signifikan antara berat badan bayi prematur sebelum dan sesudah dilakukan pemijatan (nilai p= 0.000). Berdasarkan dari hasil uji t-independent disimpulkan ada pengaruh pijat bayi yang signifikan terhadap peningkatan beratbadan bayi prematur antara kelompok intervensi dan kelompok kontrol (nilai p= 0.000). Dari hasil penelitian ini, diketahui pijat bayi sangat efektif dalam meningkatkan berat badan bayi prematur. Jadi, pijat bayi dapat digunakan juga sebagai intervensi dalam asuhan kebidanan pada bayi prematur. Kata kunci: Pijat bayi, Bayi Prematur.
Potential involvement of IL-22 and IL-22-producing cells in the inﬂ amed salivary glands of patients with Sjögren’s syndrome

Objectives In chronic inﬂ ammatory disorders, interleukin (IL)-22 may act either as a protective or as a pro-inﬂ ammatory cytokine. At mucosal sites, IL-22 is mainly produced by CD4 + T cells and by a subset of mucosal natural killer (NK) cells expressing the receptor NKp44 (NKp44 + NK cells). The aim of this study was to investigate the IL-22 expression in the salivary glands of patients with primary Sjögren’s syndrome (pSS). Methods Minor salivary gland biopsies were obtained from 19 patients with pSS and 16 with non-speciﬁ c chronic sialoadenitis. Quantitative gene expression analysis by TaqMan real-time PCR and immunohistochemistry for IL-17, IL-22, IL-23 and STAT3 (signal transducer and activator of transcription) was performed on salivary glands from patients and controls. The cellular sources of IL-22 among inﬁ ltrating inﬂ ammatory cells were also determined by ﬂ uorescence-activated cell sorting analysis and immunohistochemistry. Results IL-22, IL-23 and IL-17 were signiﬁ cantly increased at both protein and mRNA levels in the inﬂ amed salivary glands of patients with pSS. STAT3 mRNA and the tyrosine phosphorylated corresponding protein were also signiﬁ cantly increased in pSS. Th17 and NKp44 + NK cells were the major cellular sources of IL-22 in patients with pSS. Conclusions Our results suggest that, together with IL-17 and IL-23, IL-22 may play a pro-inﬂ ammatory role in the pathogenesis of pSS.
Evaluation of In-vitro Antioxidant Activity of Seagrasses: Signals for Potential Alternate Source

Background and Aim: Natural antioxidants have gained unique attention in recent years. Because of the carcinogenicity of synthetic compounds, there is a dearth for antioxidants from natural origin. Currently, seagrasses, the marine plants have gained attention for their secondary metabolites. Hence, the present study aims to examine in vitro antioxidant activity of both leaf and rhizome extracts of six seagrass species and has not yet been investigated. Methods: Crude methanolic extracts of leaf and rhizome obtained, were evaluated for total phenolic contents using Folin-Ciocalteaus method. Antioxidant potential of seagrass extracts were evaluated using total antioxidant activity, DPPH, FRAP, ABTS assay, H 2 O 2 and NO 2 scavenging assay and the phenolic compounds present in potent extracts were profiled by HPLC. Results: Maximum phenolic content and antioxidant activity was exhibited by leaf and rhizome extracts of C. rotundata followed by H. uninervis. Higher DPPH radical scavenging activity was found in leaf (78.84 ± 0.87) and rhizome extracts (75.480 ± 0.97) of C. rotundata and the lowest scavenging activity was found in the leaf and rhizome extracts of H. ovata (12.01 ± 0.63 and 5.769 ± 1.14). Among six species, C. rotundata exhibited higher radical scavenging activity containing the potential phenolic compounds. Conclusion: Present study portrays that leaf and rhizome extracts of C. rotundata acts as a potential source of antioxidant compounds with predominant presence of caffeic acid and ρ-coumaric acid that paves a way for the application of these compounds in both food and pharmaceutical industries as a multipotent antioxidant.
The regional neuronal activity in left posterior middle temporal gyrus is correlated with the severity of chronic aphasia

Background: Aphasia is one of the most disabling cognitive deficits affecting . 2 million people in the USA. The neuroimaging characteristics of chronic aphasic patients ( . 6 months post onset) remain largely unknown. Objective: The objective of this study was to investigate the regional signal changes of spontaneous neuronal activity of brain and the inter-regional connectivity in chronic aphasia. Materials and methods: Resting-state blood oxygenation level-dependent functional magnetic resonance imaging (fMRI) was used to obtain fMRI data from 17 chronic aphasic patients and 20 healthy control subjects in a Siemens Verio 3.0T MR Scanner. The amplitude of low-frequency fluctuation (ALFF) was determined, which directly reflects the regional neuronal activity. The functional connectivity (FC) of fMRI was assessed using a seed voxel linear correlation approach. The severity of aphasia was evaluated by aphasia quotient (AQ) scores obtained from Western Aphasia Battery test. Results: Compared with normal subjects, aphasic patients showed decreased ALFF values in the regions of left posterior middle temporal gyrus (PMTG), left medial prefrontal gyrus, and right cerebellum. The ALFF values in left PMTG showed strong positive correlation with the AQ score (coefficient r = 0.79, P , 0.05). There was a positive FC in chronic aphasia between left PMTG and left inferior temporal gyrus (BA20), fusiform gyrus (BA37), and inferior frontal gyrus (BA47\45\44). Conclusion: Left PMTG might play an important role in language dysfunction of chronic aphasia, and ALFF value might be a promising indicator to evaluate the severity of aphasia.
hypoxic non-small-cell lung cancer cell-derived exosomal mir-21 promotes resistance of normoxic cell to cisplatin

Purpose: To explore the effects of hypoxic non-small-cell lung cancer (NSCLC)-derived exosomes on NSCLC resistance to cisplatin. Materials and methods: Exosomes were isolated by differential centrifugation and characterized by transmission electron microscope and Western blotting. Quantitative real-time PCR was used to measure miR-21 levels. MTT assays and colony formation assays were performed to investigate the effects of hypoxia-induced exosomes on cisplatin resistance. Results: Hypoxic NSCLC cell-derived exosomes facilitate normoxic cell resistance to cisplatin. In addition, hypoxia enhanced the miR-21 expression in NSCLC cells and cell-derived exosomes. Interestingly, changes in miR-21 levels in the hypoxia-induced exosomes affected the sensitivity of recipient cells to cisplatin. Mechanically, exosomal miR-21 promoted cisplatin resistance by downregulating phosphatase and tensin homolog (PTEN). The expression of miR-21 in tumor cell lines and clinical NSCLC tumor samples was positively correlated with hypoxia-inducible factor-1 α and negatively correlated with PTEN. Moreover, high miR-21 expression was associated with shorter median survival period in patients undergoing pharmacotherapy, but no association was observed in patients who were not under pharmacotherapy. Conclusion: Exosomal miR-21 derived from hypoxic NSCLC cells may promote cisplatin resistance, which indicates that exosomal miR-21 might be a potential biomarker and therapeutic target to address NSCLC chemoresistance. exosomal miR-21. When the exosomal miR-21 was transferred into normoxic cells, it enhanced cisplatin resistance by decreasing phosphatase and tensin homolog (PTEN). This study provides new findings on the role of hypoxia-induced exosomal miR-21 in tumor chemotherapy resistance under hypoxic conditions. Since cisplatin resistance is a common response in NSCLC patients undergoing chemotherapy, this study provides an avenue that may be exploited to overcome NSCLC resistance to cisplatin.
Effects of tree species diversity on insect herbivory

1. It is broadly accepted that plant diversity influences plant–herbivore interactions, yet few studies have separated damage by different herbivore species and simultaneously tested for effects on herbivory and plant defences to elucidate the mechanisms underlying such effects. 2. This study tested for effects of tree species diversity on leaf damage by beetle larvae and caterpillars on Cordia dodecandra in a diversity experiment, and measured leaf chemical and physical traits to assess whether differences in herbivory underlie changes in plant traits. 3. Four year-old trees were sampled in 21 × 21-m plots classified as monocultures of C. dodecandra or mixtures of this species plus three other tree species. Herbivory by beetle larvae and caterpillars was estimated, and we subsequently collected undamaged leaves to quantify total phenolics and condensed tannins, trichome density, and specific leaf area. 4. A significant effect of diversity on herbivory by beetle larvae was found, with mixtures exhibiting an 80% lower mean value than monocultures. By contrast, there was no diversity effect on caterpillar herbivory. Additionally, a positive relationship was found between beetle larvae (but not caterpillar) damage and plant chemical defences, yet there was no effect of diversity on defences. Specific leaf area was higher and trichome density tended to be lower in mixtures than in monocultures, but neither trait was associated with herbivory, and damage did not explain diversity effects on these traits. 5. These findings emphasise the importance of separating diversity effects on different herbivore species and measuring plant traits associated with herbivory to better understand controls of diversity on plant–herbivore interactions.
High-Resolution Studies Of Aqueous Environments On Ancient Mars

2317. Morris, R. V. , et al. (2010), Identification of Carbonate-Rich Outcrops on Mars by the Spirit Rover, Science, 329, 421–424, doi:10.1126/science.1189667. Mueller, K. , and M. Golombek (2004), Compressional Structures on Mars, Annu. Rev. Earth Planet. Sci., 32, 435–464, doi:10.1146/annurev.earth. 32.101802. 120553. Müller, G. (1998), Starch columns: Analog model for basalt columns, J. Geophys. Res., 103(B7), 15,239–15,253.
Human papillomavirus detection in head and neck squamous cell carcinoma

Introduction Human Papillomavirus (HPV) has been associated with benign and malignant lesions in different epitheliums. The relationship between specific genotypes of high-risk HPV and some human cancers is well established. The aim of this work was to detect the HPV genotypes present in head and neck squamous cell carcinoma (HNSCC). Methods We evaluated 71 samples of patients with histopathological diagnosis of HNSCC. The DNA extraction was conducted with the QIAGEN commercial kit. HPV detection and genotyping were performed by reverse hybridisation (INNO-LiPA) following the commercial specifications. Results The mean age of the patients evaluated was 60.7 ± 13.11 years. The distribution of the lesions included 25 (35.20%) cases of squamous cell carcinoma (SCC) of the oral cavity, 23 (32.39%) of larynx, 16 (22.50%) of the oropharynx, 4 (5.63%) of paranasal sinus, and 2 (2. 80%) cases of SCC of the nostril. Of the patients, 78.9% were males, and of these 76% were tobacco users and 67.6% were alcohol consumers. The viral DNA was detected in 67.6% of the samples. The oral cavity and the larynx were the highest HPV-positivity sites with 35.40% and 29.10% respectively. The most frequent genotype was 16 as single infection (18.70%), or in combination with another HPV types. In the oral cavity and larynx the genotypes 16 or the combination 6 and 51 were present in 11.76% and 14.28%, respectively; and in the oropharynx the most frequent genotype was 16 in 22.50% of the cases, and in the paranasal sinus 50% presented infection with HPV-6. We observed that tumours with most advanced size and stage presented greater HPV positivity. Conclusions This study shows a high percentage of HPV positivity in SCC is mainly associated with high-risk HPV. It is important to highlight that viral infection, especially HPV-16, could be a risk factor in HNSCC progression.
Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti‐androgens

Taxane treatment may be a suitable therapeutic option for patients with castration‐resistant prostate cancer and high expression of constitutively active androgen receptor variants (AR‐Vs). The aim of the study was to compare the effects of cabazitaxel and androgen deprivation treatments in a prostate tumor xenograft model expressing high levels of constitutively active AR‐V7. Furthermore, mechanisms behind acquired cabazitaxel resistance were explored.
CAREER ANCHOR PROFILES : AN EXPLORATORY STUDY OF BUSINESS SCHOOL PARTICIPANTS IN FRANCE

The current business environment has become clearly more international, marked by boundaryless careers, mergers and acquisitions, restructurings, and layoffs. With the ever-growing disappearance of the longterm employment contract, employees are considered as being responsible to manage their own development. The concept of career anchor was first introduced by Schein (1978) to describe the association of self-perceived attitudes, values, needs and talents that individuals develop over time. The present study uses the Career Orientation Inventory (COI) developed by DeLong (1982a, 1982b) to measure career anchors within a population of students and alumni from a French business school in the south of France. It explores how career anchors are related to age, gender, work experience, and education and addresses the associations between various career anchors. Career anchor profiles yield characteristics which can be linked to various career stages. In addition, the findings support career anchor associations previously proposed by Feldman and Bolino (1996). The study contributes to the ongoing research on career anchors and their measurement within a French context.
The Late Cretaceous alligatoroid Brachychampsa montana (Crocodylia) : new material and putative relationships. American Museum novitates ; no. 3116

The Late Cretaceous alligatoroid Brachychampsa montana was one of the first Mesozoic taxa to be recognized as an eusuchian crocodylian referable to a modem group. A spectacular new specimen from the Hell Creek Formation of North Dakota permits a critical examination ofthe morphology and relationships ofthis species. The skull of the new specimen is described in reference to the holotype cranium. To place this species within a taxonomy reflecting phylogenetic relationships, we define the taxa Alligatoroidae and Alligatoridae to be the descent community and crown group, respectively, of extant alligatorids (Alligator, Caiman, Melanosuchus, and Paleosuchus). Preliminary comparisons suggest that Brachychampsa and its sister taxon Albertochampsa langstoni form a natural group with all alligatoroids except Diplocynodon hantoniensis. We find no evidence placing Brachychampsa within the Alligatoridae (i.e., the crown group).
Establishment of white spruce populations and responses to climatic change at the treeline, Churchill, Manitoba, Canada

Studies on recruitment of white spruce from 1785 to present document the open forest succession at Churchill, Manitoba. Advance of trees onto land emerging from Hudson Bay due to isostatic uplift and permafrost intrusion has resulted in the development of two distinct systems. Open forest and forest-tundra are distinguished by seedling establishment, crown forms, and the growth patterns of the trees. Forest-tundra plots which demonstrate transition to open forest are documented. Where the two systems were established prior to the major climatic warming, they are resistant to invasion and there is little resultant change in the position of the treeline. Once started, population growth within the open forest system tends to be self generating and is little affected by subsequent climatic cooling. The mature open forest established prior to 1800 has shown a decline in seedling establishment during the climatic warming. These sites are characterized by extensive lichen cover.
Arctic Sea Ice: Decadal Simulations and Future Scenarios Using BESM-OA

Important international reports and a significant number of scientific publications have reported on the abrupt decline of Arctic sea ice and its impact on the Global Climate System. In this paper, we evaluated the ability of the newly implemented Brazilian Earth System Model (BESM-OA) to represent Arctic sea ice and sensitivity to CO2 forcing, using decadal simulations (1980-2012) and future scenarios (2006-2100). We validated our results with satellite observations and compared them to Coupled Model Intercomparison Project, Phase 5 (CMIP5) for the same numerical experiment. BESM results for the seasonal cycle are consistent with CMIP5 models and observations. However, almost all models tend to overestimate sea ice extent in March compared to observations. The correct evaluation of minimum record of sea ice, in terms of time, spatial and area remains a limitation in Coupled Global Climate Models. Looking to spatial patterns, we found a systematic model error in September sea ice cover between the Beaufort Sea and East Siberia for most models. Future scenarios show a decrease in sea ice extent in response to an increase in radiative forcing for all models. From the year 2045 onwards, all models show a dramatic shrinking in sea ice and ice free conditions at the end of the melting season. The projected future sea ice loss is explained by the combined effects of the amplified warming in northern hemisphere high latitudes and feedbacks processes.
Cocaine-induced endocannabinoid signaling mediated by 1 sigma-1 receptors and extracellular vesicle secretion 2 3

Cellular Pathobiology Section, Electrophysiology Research Section, Structural Biology Unit, 8 Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 9 DHHS, Baltimore, Maryland 21224. ; 6 Department of Psychiatry and Behavioral Sciences, 10 Vanderbilt University Medical Center, Nashville, USA; Vanderbilt Brain Institute, Vanderbilt 11 University, Nashville, Tennessee; Department of Anatomy and Neurobiology, University of 12 Maryland School of Medicine, Baltimore, Maryland, USA 13