Miracle-dz/UniFAR-FTUs huggingface dataset:
AHR rs4410790 genotype and IgG levels: Effect modification by lifestyle factors

Inflammation is a multifaceted marker resulting from complex interactions between genetic and lifestyle factors. Emerging evidence suggests Aryl hydrocarbon receptor (AHR) protein may be implicated in the regulation of immune system and inflammatory responses. To investigate whether rs4410790 genotype (TT, TC, CC) near AHR gene is related to serum IgG levels, a marker of chronic inflammation, and whether lifestyle factors modifies the relationship, we conducted a cross-sectional study by recruiting 168 Korean adults. Participants responded to a lifestyle questionnaire and provided oral epithelial cells and blood samples for biomarker assessment. Among these participants, C allele was the minor allele, with the minor allele frequency of 40%. The rs4410790 TT genotype was significantly associated with elevated IgG levels compared with TC/CC genotypes, after adjusting for potential confounders (p = 0.04). The relationship varied significantly by levels of alcohol consumption (P interaction = 0.046) and overweight/obese status (P interaction = 0.02), but not by smoking status (P interaction = 0.64) and coffee consumption (P interaction = 0.55). Specifically, higher IgG levels associated with the TT genotype were evident in frequent drinkers and individuals with BMI≥23kg/m2, but not in their counterparts. Thus, rs4410790 genotype may be associated with IgG levels and the genetic predisposition to higher IgG levels may be mitigated by healthy lifestyle factors like infrequent drinking and healthy weight.
Biogeographic Patterns in Life-History Traits of the Yellow Clam, Mesodesma mactroides, in Sandy Beaches of South America

Abstract Demographic and life-history attributes of the yellow clam, Mesodesma mactroides, were analyzed along exposed sandy beaches of the Atlantic coast of South America, from Brazil (32°S) to Argentina (41°S), covering most of its geographical range (24–41°S). Population features varied markedly within this range and exhibited systematic geographical patterns of variation. Abundance and growth/mortality rates significantly decreased from northern (Brazil and Uruguay) to southern (Argentina) populations. Snapshot information at the edge of its northern geographical range suggests a large-scale unimodal distribution pattern. Northern populations also had an extended or quasi-continuous recruitment season, whereas Argentinean populations had seasonal recruitment that became negligible at the southernmost edge of the range (41°S). Maximum individual sizes increased nonlinearly with latitude. This result, when considered together with density patterns, provided the second large-scale evidence of scaling of population density to body size in a sandy-beach population. Lifespan increased with latitude, ranging between 3 and >7 years. Length frequency-distribution analysis revealed marked intra-annual growth patterns for two populations located 7° latitude apart. Variations in water temperature explained large-scale differences in the demography and population dynamics of the yellow clam, and the high plasticity over latitudinal gradients leads to an adjustment of the phenotype–environment relationship. Long-term studies in Uruguayan beaches suggest that wide population fluctuations are the result of intertwined forces of environmental, density-dependent, and human-induced factors operating together at different spatiotemporal scales. As this species with planktonic larvae is structured as a metapopulation, future studies should incorporate a number of hierarchical scales to better understand macroscale variations in demographic patterns and life-history traits.
The Metabolome-Wide Signature of Major Depressive Disorder

Abstract Major Depressive Disorder (MDD) is an often-chronic condition with substantial molecular alterations and pathway dysregulations involved. Single metabolite, pathway and targeted metabolomics platforms have indeed revealed several metabolic alterations in depression including energy metabolism, neurotransmission and lipid metabolism. More comprehensive coverage of the metabolome is needed to further specify metabolic dysregulation in depression and reveal previously untargeted mechanisms. Here we measured 820 metabolites using the metabolome-wide Metabolon platform in 2770 subjects from a large Dutch clinical cohort with extensive depression clinical phenotyping (1101 current MDD, 868 remitted MDD, 801 healthy controls) at baseline and 1805 subjects at 6-year follow up (327 current MDD, 1045 remitted MDD, 433 healthy controls). MDD diagnosis was based on DSM-IV psychiatric interviews. Depression severity was measured with the Inventory of Depressive Symptomatology self-report. Associations between metabolites and MDD status and depression severity were assessed at baseline and at the 6-year follow-up. Metabolites consistently associated with MDD status or depression severity on both occasions were examined in Mendelian randomization (MR) analysis using metabolite (N=14,000) and MDD (N=800,000) GWAS results. At baseline, 139 and 126 metabolites were associated with current MDD status and depression severity, respectively, with 79 overlapping metabolites. Six years later, 34 out of the 79 metabolite associations were subsequently replicated. Downregulated metabolites were enriched with long-chain monounsaturated (P=6.7e-07) and saturated (P=3.2e-05) fatty acids and upregulated metabolites with lysophospholipids (P=3.4e-4). Adding BMI to the models changed results only marginally. MR analyses showed that genetically-predicted higher levels of the lysophospholipid 1-linoleoyl-GPE (18:2) were associated with greater risk of depression. The identified metabolome-wide profile of depression (severity) indicated altered lipid metabolism with downregulation of long-chain fatty acids and upregulation of lysophospholipids, for which causal involvement was suggested using genetic tools. This metabolomics signature offers a window on depression pathophysiology and a potential access point for the development of novel therapeutic approaches.
Continuous Monitoring of Cerebral Autoregulation in Adults Supported by Extracorporeal Membrane Oxygenation

Background: Impaired cerebral autoregulation (CA) is one of several proposed mechanisms of acute brain injury in patients supported by extracorporeal membrane oxygenation (ECMO). The primary aim of this study was to determine the feasibility of continuous CA monitoring in adult ECMO patients. Our secondary aims were to describe changes in cerebral oximetry index (COx) and other metrics of CA over time and in relation to functional neurologic outcomes. Methods: This is a single-center prospective observational study. We measured Cox, a surrogate measurement of cerebral blood flow, measured by near-infrared spectroscopy, which is an index of CA derived from the moving correlation between mean arterial pressure and slow waves of regional cerebral oxygen saturation. A COx value that approaches 1 indicates impaired CA. Using COx, we determined the optimal MAP (MAPOPT), lower and upper limits of autoregulation for individual patients. These measurements were examined in relation to modified Rankin Scale (mRS) scores. Results: Fifteen patients (median age=57 years [IQR=47–69]) with 150 autoregulation measurements were included for analysis. Eleven were on veno-arterial ECMO and 4 on veno-venous. Mean COx was higher on post-cannulation day 1 than on day 2 (0.2 vs 0.09, p<0.01), indicating improved CA over time. COx was higher in VA-ECMO patients than in VV-ECMO (0.12 vs 0.06, p=0.04). Median MAPOPT for entire cohort was highly variable, ranging 55–110 mmHg. Patients with mRS 0–3 (good outcome) at 3 and 6 months spent less time outside of MAPOPT compared to patients with mRS 4–6 (poor outcome) (74% vs 82%, p=0.01). The percentage of time when observed MAP was outside the limits of autoregulation was higher on post-cannulation day 1 than on day 2 (18.2% vs 3.3%, p<0.01). Conclusions: In ECMO patients, it is feasible to monitor CA continuously at the bedside. CA improved over time, most significantly between post-cannulation days 1 and 2. CA was more impaired in VA-ECMO than VV-ECMO. Spending less time outside of MAPOPT may be associated with achieving a good neurologic outcome.
The Berlage wavelet

Symmetric wavelets are commonly used in seismic modeling studies. However, accurate simulation of many physical wave propagation phenomena requires a causal waveform possessing a certain degree of differentiability. The purpose of this note is to quantitatively describe the characteristics of a relatively unfamiliar wavelet, called the Berlage wavelet, that is appropriate for such studies.
The Safety and Efficacy of Systemic Delivery of a New Liver-de-targeted TGFβ Signaling Inhibiting Adenovirus in an Immunocompetent Triple Negative Mouse Mammary Tumor Model

Aberrant TGFβ signaling is linked to metastasis and tumor immune escape of many cancers including metastatic triple negative breast cancer (mTNBC). Previously, we have found that oncolytic adenoviruses expressing a TGFβ signaling inhibitory protein (sTGFβRIIFc) induced immune activation in a mouse TNBC (4T1) immunocompetent subcutaneous model with intratumoral injection. Systemic administration of adenoviruses can be a superior route to treat mTNBC but faces the challenges of increased toxicity and viral clearance. Thus, we created a liver-de-targeted sTGFβRIIFc- and LyP-1 peptide-expressing adenovirus (mHAdLyp.sT) with enhanced breast cancer cell tropism. Its safety and immune response features were profiled in the 4T1 model. Our data showed that the systemic administration of mHAdLyp.sT resulted in reduced hepatic and systemic toxicity. mHAdLyp.sT was also effective in increasing Th1 cytokines and anti-tumor cell populations by cytokine analysis, spleen/tumor qRT-PCR, and flow cytometry. We further tested the therapeutic effects of mHAdLyp.sT alone and in combination with immune checkpoint inhibitors (ICIs). mHAdLyp.sT alone and with all ICI combinations elicited significant inhibition of lung metastasis by histological analysis. When mHAdLyp.sT was combined with both anti-PD-1 and anti-CTLA-4 antibodies, primary 4T1 tumor growth was also significantly inhibited. We are confident in advancing this new treatment option for mTNBC.
Tocodynamometric study of uterine contractions during parturition in queens

Abstract Background: Tocodynamometry is an approach in small animal obstetrics to diagnose initiation, progress, completion, and problems related to parturition in queens. Aims: The present study was conducted to monitor uterine contractions using tocodynamometry at full term pregnancy and during queening and to correlate uterine contractile pattern with progression of queening. Methods: Once the signs of impending parturition were noted, the pressure transducer of tocodynamometer was placed on the lateral abdomen to monitor queening. The recordings were plotted as graph of time against pressure in mmHg. Uterine contractile patterns were assessed in order to study their relation to the progression of queening. Results: The initial uterine contractions had a baseline and peak pressures of 7-20 and 15-36.5 mmHg with mean time interval and frequency of 5.53 min and 1.91 peaks per 10 min, respectively, with mean change of amplitude of 15.35 mmHg. The progressive baseline and peak pressures of 15-32.5 and 24-62.3 mmHg increased to 20-55 and 30-89.2, respectively, with an increase in mean frequency from 3.88 to 5.25 peaks per 10 min and increase in mean change of amplitude from 25.21 to 33.87 mmHg, followed by decrease in mean time interval from 2.82 to 1.91 min in expulsive uterine contractions. Conclusion: Monitoring uterine contractions using tocodynamometer helps in understanding progression of queening and problems that may rise during parturition. It was observed that during queening, baseline and peak pressures of uterine contractions remain the same, irrespective of presentation of kittens at birth.
Electrical conductivity and crustal structure beneath the central Hellenides around the Gulf of Corinth (Greece) and their relationship with the seismotectonics

A deep magnetotelluric sounding (MTS) investigation in the western part of the Gulf of Corinth has revealed a complex electrical image of the crustal structure. The geotectonic structure of the Parnassos unit and the Transition zone in the central Hellenides, overthrusting the Pindos zone both towards the west and towards the south, has been clearly identified by its higher resistivity and its intrinsic anisotropy related to the N–S strike of the Hellenides range. Subsequent N–S extension of the Gulf introduced another heterogeneous anisotropy characteristic that corresponds to E–W-trending normal faults on both sides of the Gulf. The 2-D modelling of the MTS results reveals the existence of a relatively conductive layer about 4 km thick at a depth greater than 10 km in the middle crust. It corresponds to a ductile detachment zone suggested by microseismic and seismic studies (King et al. 1985; Rigo et al. 1996; Bernard et al. 1997a). It may be attributed to the phyllite series lying between the allochthonous Hellenic nappes and the autochthonous Plattenkalk basement. Towards the east, under the Pangalos peninsula, approaching the internal Hellenides, the detachment zone could root deeply into the lower crust. Some strong local electrical anomalies are observed, reaching the conductive layer in the middle crust, such as that under the Mamousia fault and under the front of the overthrust of the Transition zone on the Pindos zone. Other anomalies affect only the shallower zones such as that beneath the Helike fault and in the Psaromita peninsula. These shallower anomalies provide complementary information to the study of spatial and temporal variations of the seismic anisotropy in relation to the short- and long-term tectonic activity of the Gulf (Bouin et al. 1996; Gamar et al. 1999).
Insights into the early Tibetan Plateau from (U–Th)/He thermochronology

The central Songpan–Ganzi belt, located on the eastern margin of the Tibetan Plateau, has a similar high elevation and low relief to parts of central Tibet. Thermochronological studies from the central Tibetan Plateau reveal a history of slow exhumation (rates <0.05kmMa−1) since 45Ma; however, the exhumation history of the central Songpan–Ganzi belt is unknown. To address this, we conducted an apatite and zircon (U–Th)/He thermochronology study of bedrock samples collected across the central Songpan–Ganzi belt and into central parts of the Tibetan Plateau. Zircon (U–Th)/He ages range from 54.2±7.5 to 146.5±10.0Ma and the majority of apatite (U–Th)/He ages fall between 74.7±19.0 and 35.7±9.4Ma. Thermal history models of these data show rapid cooling in the late Mesozoic and much slower cooling diagnostic of low rates of erosion throughout most of the Cenozoic. The late Mesozoic rapid cooling is consistent with the existence of significant topography and relief at least in some parts of the Songpan–Ganzi belt at that time. We find no evidence for a regional Miocene acceleration in erosion, although three samples from the headwaters of the Salween and Mekong rivers gave younger AHe ages between 15 and 16Ma that reflect an acceleration in river incision. Supplementary material: Laser ablation–inductively coupled plasma mass spectrometry zircon U–Pb data from central and eastern Tibet are available at www.geolsoc. org.uk/SUP18647.
Stratocumulus Clouds in Southeastern Pacific Simulated by Eight CMIP5–CFMIP Global Climate Models

AbstractThis study examines the stratocumulus clouds and associated cloud feedback in the southeast Pacific (SEP) simulated by eight global climate models participating in phase 5 of the Coupled Model Intercomparison Project (CMIP5) and Cloud Feedback Model Intercomparison Project (CFMIP) using long-term observations of clouds, radiative fluxes, cloud radiative forcing (CRF), sea surface temperature (SST), and large-scale atmosphere environment. The results show that the state-of-the-art global climate models still have significant difficulty in simulating the SEP stratocumulus clouds and associated cloud feedback. Comparing with observations, the models tend to simulate significantly less cloud cover, higher cloud top, and a variety of unrealistic cloud albedo. The insufficient cloud cover leads to overly weak shortwave CRF and net CRF. Only two of the eight models capture the observed positive cloud feedback at subannual to decadal time scales. The cloud and radiation biases in the models are associated.
The Impact of Covid-19 Pandemic on Mental Health Services: A Comparison Between First Psychiatric Consultations Before and After the Pandemic

Objective A high rate of onset or exacerbation of several mental disorders has been observed during the COVID-19 pandemic. However, the risk contributing to mental distress during the pandemic remains unclear. The study aims to evaluate the risk of the onset of mental disorders by comparing the number of requests for the first psychiatric consultation before and after the COVID-19 pandemic at the psychiatric outpatient services of Varese, a small town in Northern Italy. Method This observational retrospective study aims to compare the requests for the first psychiatric consultation at the outpatient services of Varese during the 14-month period before COVID-19 pandemic (from 1st January 2019 to 28th February 2020) versus the 14-month period after the pandemic (from 1st March 2020 to 31st May 2021) extracted from the server SIPRL-Psicheweb database (Sistema Informativo della Psichiatria, Lombardy Region). For each patient, socio-demographic features and clinical data (psychiatric diagnosis, psychiatric comorbidities, previous psychiatric records, and previous hospitalization in the psychiatric ward) were collected. Results Three hundred ninety-five consultations were made during the pre-COVID period and 346 during the post-COVID period. No statistically significant difference was found between the number of first consultation requests in the two periods evaluated but a slight decrease in the total number during the pandemic period (395 vs 346; p=0.07) can be noticed. In the subjects of the pre-COVID group, a statistically significant association was detected with no previous psychiatric records (“absent”) and with stressor-related disorders. In the post-COVID group, a statistically significant correlation between “present” previous records and anxiety-depressive disorders emerged. Conclusions It has been observed that anxiety-depressive disorders increased in the post-COVID-19 period compared to the pre-COVID-19, instead of stressor-related disorders. This might be because stressor-related disorders may be treated by general practitioners with no psychiatric interventions. Most of the first consultations during the period of the COVID-19 pandemic were for patients who already had contact with psychiatric services. The study shows an increasing request for care by more severe patients in the first phase of the SARS-CoV-2 pandemic. Further research is needed to investigate the long-term impact of the COVID-19 pandemic on emergency departments and hospital services.
Bioerosional innovation for living in carbonate hardgrounds in the Early Ordovician of Sweden

Some of the world's oldest macroborings occur in hardgrounds in lower Ordovician (Arenig) limestones exposed on the island of Oland, southern Sweden. The trace fossils, which are described here as Gastrochaenolites oelandicus isp. nov., appear to be dwelling structures excavated in the indurated substrate by invertebrates of unknown taxonomic affinity. They are the oldest examples of this ichnogenus. The appearance of a macroboring life habit at this early time represents a revolutionary new adaptive strategy for inhabiting carbonate hardgrounds. However, this innovative strategy apparently was not successful for the long term, because this particular macroboring taxon seems to have disappeared shortly after its early Ordovician appearance.
Strength in Diversity: Multi-Branch Representation Learning for Vehicle Re-Identification

This paper presents an efficient and lightweight multi-branch deep architecture to improve vehicle reidentification (V-ReID). While most V-ReID work uses a combination of complex multi-branch architectures to extract robust and diversified embeddings towards re-identification, we advocate that simple and lightweight architectures can be designed to fulfill the Re-Idtask without compromising performance. We propose a combination of Grouped-convolution and Loss-Branch-Split strategies to design a multi-branch architecture that improve feature diversity and feature discriminability. We combine a ResNet50 global branch architecture with a BotNet self-attention branch architecture, both designed within a Loss-Branch-Split (LBS) strategy. We argue that specialized loss-branch-splitting helps to improve re-identification tasks by generating specialized re-identification features. A lightweight solution using grouped convolution is also proposed to mimic the learning of loss-splitting into multiple embeddings while significantly reducing the model size. In addition, we designed an improved solution to leverage additional metadata, such as camera ID and pose information, that uses 97% less parameters, further improving re-identification performance. In comparison to state-of-the-art (SoTA) methods, our approach outperforms competing solutions in Veri-776 by achieving 85.6% mAP and 97.7% CMC1 and obtains competitive results in Veri-Wild with 88.1% mAP and 96.3% CMC1. Overall, our work provides important insights into improving vehicle re-identification and presents a strong basis for other retrieval tasks. Our code is available at the link.
Psychosocial stress and microRNA expression profiles in myometrial tissue of women undergoing surgical treatment for uterine fibroids

Uterine leiomyomas (fibroids) are the most common non-cancerous tumor affecting women. Psychosocial stress is associated with fibroid risk and severity. The relationship between psychosocial stress and fibroid pathogenesis may involve alterations in microRNAs (miRNAs) although this has yet to be examined. We investigated associations between two psychosocial stress measures, a composite measure of recent stressful life events and perceived social status, with expression levels of 401 miRNAs in myometrium (n = 20) and fibroids (n = 44; 20 matched between tissues) from pre-menopausal women who underwent surgery for fibroid treatment. We used linear regressions to identify psychosocial stressors associated with miRNAs, adjusting for covariates (age, body mass index, and race/ethnicity). Psychosocial stressors were modeled as ordinal variables and results were considered statistically significant if the overall variable significant was below false discovery threshold (FDR < 0.10) and showed a monotonic dose-response (nominal p-trend < 0.05). In the myometrium, 16 miRNAs were significantly associated with total stressful events and two miRNAs were associated with perceived social status. No fibroid miRNAs were associated with either stress measure. Pathway analyses revealed miRNA-mRNA targets were significantly enriched (FDR < 0.05) in pathways relevant to cancer/tumor development. Of the 74 differentially expressed miRNAs between myometrium and fibroids (p < 0.05), miR-27a-5p was also associated with stress exposure. Our pilot analysis suggests that psychosocial stress is associated with changes in myometrium miRNAs, and thus, plays a role in the pathogenesis of fibroids from healthy myometrium.