Miracle-dz/UniFAR-FTUs huggingface dataset:
Epidemiological features of brucellosis in the Republic of Azerbaijan at the present stage

Modern brucellosis is characterized by high variability of clinical symptoms. The evolution of brucellosis in modern conditions is heading in the direction of acute brucellosis increasing in its frequency with the early development of focal metastatic and infectious-allergic lesions, which increase the severity of the disease. The purpose of our study was to analyze the epidemiological features of acute brucellosis in the Republic of Azerbaijan. Of the 178 patients surveyed, only 120 persons fully met the criteria, which formed the main group. Statistical analysis of the results of the study was performed using the programs "SPSS 20.0", "STATISTICA 6.0". Acute brucellosis was found to be 7.5 times more frequent in women aged 40 to 49 years (p <0.05), whereas no cases of brucellosis were recorded in the group of women that are under 19 years of age. The highest infection rate was recorded among farm workers and veterinarians, namely 64.17±4.38%. When the sources of infection were identified, it was found that in the vast majority of 57.5±4.51% of persons, the source of infection could not be established or was mixed.
Effects of pH on simultaneous Cr(VI) and p-chlorophenol removal and electrochemical performance in Leersia hexandra constructed wetland-microbial fuel cell

ABSTRACT Cr(VI) and p-chlorophenol (4-CP) are common pollutants in the aquatic environment but are difficult to degrade and have complex toxic effects. A downflow Leersia hexandra microbial fuel cell (DLCW-MFC) system was constructed to purify Cr(VI) and 4-CP polluted wastewater, as well as to investigate the effects of different pHs on Cr(VI) and 4-CP removal, electrochemical performance, physiological and biochemical responses, and Cr enrichment status of L. hexandra. The results showed that the DLCW-MFC had the highest Cr(VI) and 4-CP removal rates at pH 6.5, which were 99.0% and 78.6%, respectively. At the same time, 543 mV output voltage and 72.25 mW/m2 power density of the system were generated at pH 6.5, which were better than those at pH 7.4 and pH 5.8. The electrochemical performance result showed that pH 6.5 enhanced charge transfer ability and ion diffusion ability of the system. pH 6.5 also promoted growth and photosynthesis, and enhanced the Cr enrichment capacity (4.56 mg/10 plants) of L. hexandra. These results demonstrate that pH 6.5 was the optimum pH for the DLCW-MFC synchronous treatment of Cr(VI) and 4-CP as well as the generation of electricity. The DLCW-MFC designed in this study will provide a reference for purifying polluted wastewater and generating electricity. GRAPHICAL ABSTRACT
Site-dependent shaping of field potential waveforms

Abstract The activity of neuron populations gives rise to field potentials (FPs) that extend beyond the sources. Their mixing in the volume dilutes the original temporal motifs in a site-dependent manner, a fact that has received little attention. And yet, it potentially rids of physiological significance the time-frequency parameters of individual waves (amplitude, phase, duration). This is most likely to happen when a single source or a local origin is erroneously assumed. Recent studies using spatial treatment of these signals and anatomically realistic modeling of neuron aggregates provide convincing evidence for the multisource origin and site-dependent blend of FPs. Thus, FPs generated in primary structures like the neocortex and hippocampus reach far and cross-contaminate each other but also, they add and even impose their temporal traits on distant regions. Furthermore, both structures house neurons that act as spatially distinct (but overlapped) FP sources whose activation is state, region, and time dependent, making the composition of so-called local FPs highly volatile and strongly site dependent. Since the spatial reach cannot be predicted without source geometry, it is important to assess whether waveforms and temporal motifs arise from a single source; otherwise, those from each of the co-active sources should be sought.
Larval morphology of Amazonia foam‐nesting frogs of the genus Engystomops (Anura: Leptodactylidae: Leiuperinae)

The highly differentiated anuran larvae make them an interesting and complementary source of information to understand anuran evolution. Among neotropical foam‐nesting frogs, the available information on tadpole morphology for the subfamily Leiuperinae remains largely incomplete and variably reported among genera; in the monophyletic genus Engystomops it is still incipient. Herein, we summarize available information on larval morphology for five of the nine known species of Engystomops, three of them for the first time, reporting external morphology, buccopharyngeal cavity, and skeleton. The tadpoles of the genus have an overall generalized morphology and many traits are conserved across species. Nevertheless, many characters are systematically informative and some are diagnostic for some species, as the paravertebral gland in Engystomops petersi and the dorsally directed spiracle in Engystomops puyango. Other characters provide support for some subclades within the genus. Moreover, some traits, such as the direction of the vent tube, supports the close relationship between Engystomops and Physalaemus, whereas other support the existence of these two as distinct genera, such as the overall shape of the lateral ridge papillae and the presence of a processus pseudopterygoideus.
Evaluation of Delafloxacin against a Burkholderia pseudomallei Efflux Mutant Panel

Resistance-nodulation-cell division (RND) efflux pumps play a major role in intrinsic and acquired antibiotic resistance in Burkholderia pseudomallei, and these pumps are its only known multidrug resistance determinants. Fluoroquinolones have performed poorly in clinical settings and are currently not recommended for treatment of B. pseudomallei infections. ABSTRACT In vitro activities of delafloxacin and ciprofloxacin were evaluated against Burkholderia pseudomallei mutants expressing or lacking defined resistance-nodulation-cell division (RND) efflux pumps using CLSI methodology at pHs of 5.8 and 7.2. Delafloxacin MIC values were as much as 8-fold lower at pH 5.8 than those at pH 7.2, while ciprofloxacin MICs increased as much as 8-fold. The data from this study suggest that compared to ciprofloxacin, delafloxacin may have improved efflux avoidance, notably at acidic pH. In contrast to ciprofloxacin, delafloxacin may thus retain its therapeutic potential, even in BpeEF-OprC efflux-pump-expressing B. pseudomallei strains that compromise the use of fluoroquinolones, such as ciprofloxacin. IMPORTANCE Resistance-nodulation-cell division (RND) efflux pumps play a major role in intrinsic and acquired antibiotic resistance in Burkholderia pseudomallei, and these pumps are its only known multidrug resistance determinants. Fluoroquinolones have performed poorly in clinical settings and are currently not recommended for treatment of B. pseudomallei infections. While the reasons for the poor clinical performance of this pathogen remain unclear, efflux may be partially responsible since fluoroquinolones like ciprofloxacin are prone to efflux by RND pumps, notably BpeEF-OprC. In vitro efficacy testing using a panel of efflux-proficient and efflux-deficient strains allows identification of fluoroquinolones that compared to ciprofloxacin are less prone to efflux.
The potential role of serum expression profile of long non coding RNAs, Cox2 and HOTAIR as novel diagnostic biomarkers in systemic lupus erythematosus

Background The role of the long non-coding RNAs (lncRNAs) in the pathogenesis of systemic lupus erythematosus (SLE) is mostly unknown, despite increasing evidence that lncRNAs extensively participate in physiological and pathological conditions. Aim To detect the level of lncRNA-Cox2, HOTAIR, IL-6, and MMP-9 in the serum of SLE patients and to correlate these levels with disease activity and patients’ clinical and laboratory data to evaluate the value of these biomarkers for SLE diagnosis and assessment of disease activity. Methods Blood samples from 58 SLE patients, and 60 healthy controls (HCs) were used for detection of lncRNAs-Cox2 and HOTAIR expression levels by real-time polymerase chain reaction. Both IL-6 and MMP-9 serum levels were assayed by enzyme-linked immunosorbent assay. Lupus activity was assessed with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Results The serum expression levels of lncRNA-Cox2 and HOTAIR were significantly up-regulated in SLE patients vs HCs (fold change [median (IQR) was 1.29(0.81–1.71, P<0.0001) and 2.68(0.95–3.67), P = 0.038) for lncRNA-Cox2 and HOTAIR, respectively. Serum levels of both IL-6 and MMP-9 were significantly high in SLE patients compared with HCs (P≤0.001 for each). The up-regulated lncRNA-Cox2 was positively associated with the presence of neurological manifestations in SLE patients (P = 0.007). Furthermore, HOTAIR expression level had significantly positive correlation with IL-6 (r = 0.578, P<0.0001), MMP-9 level (r = 0.762, P<0.0001), nephritis grades (r = 0.296, P = 0.024) and proteinuria (r = 0.287, P = 0.035). LncRNA-Cox2 showed sensitivity and specificity 72.4%, and 100.0% respectively. HOTAIR sensitivity was 60.3%, and specificity was 100.0%. By multiple logistic regression analysis, lncRNA-Cox2 and HOTAIR were found as SLE independent predictors. Conclusion LncRNA-COX2 and HOTAIR can be used as new non-invasive biomarkers for the diagnosis of SLE.
Sperm competition in yellow dung flies: No consistent effect of sperm size

The male competition for fertilization that results from female multiple mating promotes the evolution of increased sperm numbers and can impact sperm morphology, with theory predicting that longer sperm can at times be advantageous during sperm competition. If so, males with longer sperm should sire more offspring than competitors with shorter sperm. Few studies have directly tested this prediction, and findings are inconsistent. Here we assessed whether longer sperm provide a competitive advantage in the yellow dung fly (Scathophaga stercoraria; Diptera: Scathophagidae). Initially, we let brothers with different temperature‐mediated mean sperm lengths compete – thus minimizing confounding effects of genetic background – and found no clear advantage of longer sperm. We then used flies from lines subjected to bidirectional selection on phenoloxidase activity that had shown correlated evolutionary responses in sperm and female spermathecal duct lengths. This experiment also yielded no main effect of sperm size on siring success. Instead, there was a trend for a shorter‐sperm advantage, but only when competing in females with longer spermathecal ducts. Our data corroborated many previously reported findings (last‐male precedence, effects of copula duration and body size), suggesting our failure to find sperm size effects is not inherently due to our experimental protocols. We conclude that longer sperm are not competitively superior in yellow dung flies under most circumstances, and that, consistent with previous work, in this species competitive fertilization success is primarily determined by the relative numbers of sperm competing.
High fat diets induce early changes in gut microbiota that may serve as markers of ulterior altered physiological and biochemical parameters related to metabolic syndrome. Effect of virgin olive oil in comparison to butter

Butter and virgin olive oil (EVOO) are two fats differing in their degree of saturation and insaponifiable fraction. EVOO, enriched in polyphenols and other minority components, exerts a distinct effect on health. Using next generation sequencing, we have studied early and long-term effects of both types of fats on the intestinal microbiota of mice, finding significant differences between the two diets in the percentage of certain bacterial taxa, correlating with hormonal, physiological and metabolic parameters in the host. These correlations are not only concomitant, but most noticeably some of the changes detected in the microbial percentages at six weeks are correlating with changes in physiological values detected later, at twelve weeks. Desulfovibrionaceae/Desulfovibrio/D. sulfuricans stand out by presenting at six weeks a statistically significant higher percentage in the butter-fed mice with respect to the EVOO group, correlating with systolic blood pressure, food intake, water intake and insulin at twelve weeks. This not only suggests an early implication in the probability of developing altered physiological and biochemical responses later on in the host lifespan, but also opens the possibility of using this genus as a marker in the risk of suffering different pathologies in the future.
Rational numbers : an integration of research

Contents: Part I:Overview. T.P. Carpenter, E. Fennema, T.A. Romberg, Toward A Unified Discipline of Scientific Inquiry. Part II:Content Analyses of Rational Numbers. M.J. Behr, G. Harel, T. Post, R. Lesh, Rational Numbers: Toward a Semantic Analysis -- Emphasis on the Operator Construct. T.E. Kieren, Rational and Fractional Numbers: From Quotient Fields to Recursive Understanding. Part III:Students' Thinking. N.K. Mack, Learning Rational Numbers With Understanding: The Case of Informal Knowledge. L.B. Resnick, J.A. Singer, Protoquantitative Origins of Ratio Reasoning. S.J. Lamon, Ratio and Proportion: Children's Cognitive and Metacognitive Processes. Part IV:Teachers and Teaching. D.L. Ball, Halves, Pieces, and Twoths: Constructing and Using Representational Contexts in Teaching Fractions. C.A. Brown, A Critical Analysis of Teaching Rational Number. J.A. Hiebert, Benefits and Costs of Research That Links Teaching and Learning Mathematics. J.T. Sowder, N. Bezuk, L.K. Sowder, Using Principles From Cognitive Psychology to Guide Rational Number Instruction for Prospective Teachers. Part V:Assessment. S.P. Marshall, Assessment of Rational Number Understanding: A Schema-Based Approach. Part VI:Curriculum and Instruction. L. Streefland, Fractions: A Realistic Approach. T.R. Post, K.A. Cramer, M. Behr, R. Lesh, G. Harel, Curriculum Implications of Research on the Learning, Teaching, and Assessing of Rational Number Concepts.
Review and demonstration of equations applied to models of filtering facepiece respirator particle capture efficiency

Abstract The use of filtering facepiece respirators (FFRs) of various types increased dramatically by both workers and the public during the ongoing COVID-19 pandemic. This increased use has, likewise, instigated a proliferation of research on the qualities of FFRs. An aspect of FFR development and optimization involves the use of mathematical models that predict filter efficiency based on various filter characteristics while also considering a number of particle capture forces. An evaluation of current literature failed to identify a publication that provides a comprehensive assessment of the models developed to predict filter efficiency. The purpose of this review was, therefore, to describe models developed to include the forces associated with diffusion, interception, impaction, and electrostatic attraction as they contribute to the efficiency of an entire filter. The literature review was augmented with figures created with the use of many of the models discussed to compare different models of the same force as well as to illustrate the influence of electrostatic forces on overall filter efficiency.
How does the COVID-19 pandemic impact medication adherence of patients with chronic disease?: A systematic review

Objective To determine how the COVID-19 pandemic impacts patients with chronic disease medication adherence. Methods Four electronic databases, PubMed, MEDLINE, Web of Science, and CINAHL Plus Full Text, were searched for literature between 2019 and 2021. Abstracts and later full texts were independently screened by the authors of this review using inclusion and exclusion criteria to determine relevance to our study. Joanna Briggs Institute (JBI) critical appraisal tools were used to assess the quality of included texts. Relevant information and data from the included texts were extracted into tables for data synthesis and analysis. Results Ten studies met the study criteria, the most popular study design was cross-sectional design (n = 9, 90.0%), others were case series (n = 1, 10.0%). Barriers to medication adherence and facilitators of medication adherence were the major two themes that participants reported regarding the impact of COVID-19 on medication adherence. Moreover, these two main themes have been organized in sub-themes that are dealt with in-depth. Discussion Our results could heighten healthcare providers, stakeholders, and policy leaders’ awareness of providing appropriate support for chronic disease patients, especially regarding medication adherence. Future research incorporating programs that support patients’ needs is recommended.
Evaluating the Role of Antibiotics in Patients Admitted to Hospital With Decompensated Cirrhosis: Lessons From the ATTIRE Trial

INTRODUCTION: Hospital-acquired infections (HAI) are common in cirrhosis with antibiotics frequently used to prevent infections, but their efficacy for this role is unknown. To investigate this, we used Albumin to Prevent Infection in Chronic Liver Failure (ATTIRE) data to evaluate whether antibiotic use in patients without infection prevented HAI. METHODS: In ATTIRE patients without infection at baseline grouped by antibiotic prescription or not, we studied HAI during trial treatment period and mortality, with propensity score matching to account for differences in disease severity. RESULTS: Two hundred three of 408 patients prescribed antibiotics at enrollment did not have infection and they were more unwell than noninfected patients not given antibiotics. There were no differences in subsequent HAI comparing antibiotic treated (39/203, 19.2%) to nonantibiotic treated (73/360, 20.3%; P = 0.83). Twenty-eight-day mortality was higher in antibiotic-treated patients (P = 0.004) likely reflecting increased disease severity. Matching groups using propensity scoring revealed no differences in HAI or mortality. In noninfected patients at enrollment treated with/without rifaximin, there were no differences in HAI (P = 0.16) or mortality, confirmed with propensity matching. Patients given long-term antibiotic prophylaxis at discharge had no differences in 6-month mortality compared with nonantibiotic patients, although antibiotic-treated patients had more infections at trial entry, with numbers too small for matching. DISCUSSION: Half of antibiotics at study entry were given to patients without an infection diagnosis which did not reduce the overall risk of HAI or improve mortality. This supports prompt de-escalation or discontinuation of antibiotics guided by culture sensitivities at 24–48 hours after commencement if no infection and the patient is improving.
Low Prevalence of Endoscopic Screening for Barrett's Esophagus in a Screening-Eligible Primary Care Population

INTRODUCTION: Despite societal recommendations supporting Barrett's esophagus (BE) screening, it is unknown what proportion of eligible patients is screened in primary care. We assessed the proportion of BE screening- eligible patients evaluated in the primary care setting receiving upper esophagogastroduodenoscopy (EGD) and identified factors associated with undergoing EGD. METHODS: This was a retrospective study of BE screening-eligible patients, as defined by the American College of Gastroenterology's BE guidelines, in a multipractice healthcare network consisting of 64 internal medicine practices and 94 family medicine (FM) practices. The proportion undergoing EGD, prevalence of BE and esophageal adenocarcinoma (EAC) in this group, and patient and provider factors associated with undergoing EGD were assessed. Multivariable logistic regression was performed to identify independent predictors of undergoing EGD. RESULTS: Of 1,127 screening-eligible patients, the mean age was 65.2 ± 8.6 years; 45% were obese; and 61% were smokers. Seventy-three percent were seeing FM; 94% were on proton pump inhibitors; and 44% took ≥1 gastroesophageal reflux disease (GERD) medication. Only 39% of patients (n = 436) had undergone EGD. The overall prevalence of BE or EAC was 9.9%. Of 39 (9%) referred for BE screening as the primary indication, BE/EAC prevalence was 35.1%. Factors associated with increased odds of having EGD were symptomatic GERD despite treatment (odds ratio [OR] 12.1, 95% confidence interval [CI] 9.1‐16.3), being on ≥1 GERD medication (OR 1.4, 95% CI 1.0‐1.9), and being an FM patient (OR 1.5, 95% CI 1.1‐2.1). DISCUSSION: In this large, primary care population, only 39% of screening-eligible patients underwent EGD. Most of the examinations were triggered by refractory symptoms rather than screening referrals, highlighting a need for improved dissemination and implementation of BE screening.
Financial Vulnerability of American College of Surgeons-Verified Trauma Centers: A Statewide Analysis.

BACKGROUND Although trauma centers represent an integral part of healthcare in the US, characterization of their financial vulnerability has not been reported. We sought to characterize the financial health and vulnerability among California trauma centers and identify factors associated with high and low vulnerability. STUDY DESIGN The RAND Hospital Data financial dataset was used to evaluate all American College of Surgeons (ACS)-verified trauma centers in California. Financial vulnerability of each center was calculated using 6 metrics to calculate a composite Financial Vulnerability Score (FVS). Tertiles of the FVS were generated to classify trauma centers as high, medium, or low financial vulnerability. Hospital characteristics were also analyzed and compared. RESULTS Forty-seven ACS trauma centers were identified. Nine were Level I, 27 were Level II, and 8 were Level III. Level I centers encompassed the greatest proportion of the high FVS tier (44%), whereas Level II and III centers were the most likely to be in the middle and lower tiers, respectively (44%; 63%). Lower FVS centers had greater asset:liability ratios, operating margins, and days cash on hand compared with the 2 higher tiers, whereas high FVS centers showed a greater proportion of uncompensated care, outpatient share rates, outpatient surgeries, and longer days in net accounts. Lower FVS centers were more likely to be teaching hospitals and members of a larger corporate entity. CONCLUSION Many ACS trauma centers are at moderate/high risk for financial vulnerability and disparate impacts of stressor events, and the FVS may represent a novel metric that could be used at the local or statewide level.