Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing the dynamics and macromolecular interactions of the intrinsically disordered protein YY1

Abstract YY1 is a ubiquitously expressed, intrinsically disordered transcription factor involved in neural development. The oligomeric state of YY1 varies depending on the environment. These structural changes may alter its DNA binding ability and hence its transcriptional activity. Just as YY1’s oligomeric state can impact its role in transcription, so does its interaction with other proteins such as FOXP2. The aim of this work is to study the structure and dynamics of YY1 so as to determine the influence of oligomerisation and associations with FOXP2 on its DNA binding mechanism. The results confirm that YY1 is primarily a disordered protein, but it does consist of certain specific structured regions. We observed that YY1 quaternary structure is a heterogenous mixture of oligomers, the overall size of which is dependent on ionic strength. Both YY1 oligomerisation and its dynamic behaviour are further subject to changes upon DNA binding, whereby increases in DNA concentration result in a decrease in the size of YY1 oligomers. YY1 and the FOXP2 forkhead domain were found to interact with each other both in isolation and in the presence of YY1-specific DNA. The heterogeneous, dynamic multimerisation of YY1 identified in this work is, therefore likely to be important for its ability to make heterologous associations with other proteins such as FOXP2. The interactions that YY1 makes with itself, FOXP2 and DNA form part of an intricate mechanism of transcriptional regulation by YY1, which is vital for appropriate neural development.
The Behavior of Sands Under Seismic Loading Conditions

Abstract : The volume change characteristics and the dynamic stress-strain properties of dry sand subjected to cyclic shear strains have been investigated and used to check the applicability of a simple method for predicting the vertical settlements due to compaction in layers of dry cohesionless soils subjected to seismic loading conditions. Dynamic testing of a medium quartz sand, performed by repeated load simple shear equipment, indicated that the shear modulus increased slightly with increasing numbers of cycles and with increasing relative density and decreases significantly with increasing values of shear strain amplitude. Modulus values determined near the upper limit of shear strain amplitude that might be expected to be induced by seismic shaking (0.1 percent) were as much as 40 percent lower than modulus values obtained at the lowest values of shear strain that were investigated (0.01 percent). (Author)
Quality of Life in Patients With Confirmed and Suspected Spinal CSF Leaks

Background and Objectives Spontaneous intracranial hypotension (SIH) is a debilitating condition typically producing orthostatic headache limiting upright time. SIH is often difficult to diagnose and treat, negatively affecting quality of life (QoL) in patients with the disorder. We studied QoL in patients with confirmed and suspected SIH using standardized instruments, including suicidality. Methods We performed a cross-sectional survey of adult patients with confirmed and clinically suspected SIH evaluated in our Headache and Facial Pain Program from 2016 to 2022. Using an online data collection tool (REDCap V 11.2.2), participants completed validated questionnaires assessing general well-being (SF-36), depression (PHQ-9), generalized anxiety disorder-7 (GAD-7), spiritual well-being during chronic illness therapy (FACIT-Sp-12), and headache impact (HIT-6). Subsequently, we interviewed willing participants to administer the Columbia-Suicide Severity Rating Scale (C-SSRS) assessing suicidal behavior and ideation. Results A total of 234 patients met inclusion criteria and were invited to participate in the study, and 95 patients (59 confirmed and 36 clinically suspected) completed the questionnaires. The average age of the cohort was 51.1 years (SD: 15.5), predominantly female (69.5%), White (91.6%), and married (69.5%). Three-quarters (74.5%) scored within the most severe headache category (HIT-6). SF-36 scores were significantly inferior (p < 0.0001) to the general population and lower than reported values for patients with multiple sclerosis and idiopathic intracranial hypertension. Almost half (49.1%) of respondents scored in the moderate depression range or worse (>10), and 25.4% scored with moderate anxiety or worse (>10). FACIT-Sp-12 scores were significantly worse (p < 0.0001) in symptomatic participants than in the validation cohorts of patients with AIDS and cancer. Of the 67 respondents who completed the C-SSRS, more than half (64.2%) endorsed a wish to be dead, and 22.4% had demonstrated suicidal behavior. Patients with symptom-free SIH (n = 22) scored significantly better than symptomatic patients, comparable with the general population. Discussion Based on our single-center cohort, SIH is associated with severe headache pain and high rates of depression, anxiety, and disability, affecting basic activities of daily living. Individuals with confirmed and suspected spinal CSF leaks scored similarly on these measures including suicidality. Outcomes were comparable with the general population after successful treatment or spontaneous remission. Improved identification and treatment of SIH are imperative to improve patients' QoL.
An experimental study of incongruent dissolution of CaCO3 under analogue glacial conditions

Abstract This paper addresses the nature of incongruent dissolution of calcite in glacial settings using an experimental approach. Various CaCO3 samples were comminuted using two contrasting techniques (dry machine-milling, and hand-grinding of an ice-water mixture) and dissolved to calcite saturation in both high-pCO2 (10−2 atm) and low-pCO2 (10−3.5 = atmospheric) conditions. Ion yields of Ca, Mg and Sr were determined at the end of the experiments. Leachates displayed enhancement of Mg/Ca and Sr/Ca by a factor of 1.3–8.3 compared with bulk solid carbonate. Lower Mg/Ca and Sr/Ca ratios under higher-pCO2 conditions reflect the percentage dissolution of the carbonate, not the pCO2 per se. The experimental results imply that reported natural incongruent dissolution is readily reproducible in the laboratory and is primarily dependent on the water/rock ratio. Quantitative analysis of new and previous results suggests that the effect relates to the most reactive 0.15–0.25% of the sample, equating volumetrically to the outer few lattice layers, and it is interpreted as an anomalous leaching behaviour of calcite surfaces freshly exposed by crushing. This phenomenon could serve as an index of the relative efficiencies of fragmenting and dissolutional processes in glacial environments.
Multilevel Analysis of the Relationship Between Prescribing Institutions and Medication Adherence Among Patients With Hypertension and Diabetes in Korea

Objectives This study investigated the relationship between prescribing institutions and medication adherence among patients newly diagnosed with hypertension and diabetes. Methods This study investigated patients with new prescriptions for hypertension and diabetes in Korea in 2019 with using data collected from general health screenings. A multilevel logistic regression model was applied to explore the relationship between patients’ first prescribing institution and their medication adherence, defined as a medication possession ratio (MPR) over 80%. Results The overall adherence rates were 53.7% and 56.0% among patients with hypertension and diabetes, respectively. The intraclass correlation coefficients were 13.2% for hypertension and 13.8% for diabetes (p<0.001), implying that the first prescribing institution had a significant role in medication adherence. With clinics as the reference group, all other types of hospitals showed an odds ratio (OR) less than 1.00, with the lowest for tertiary hospitals (OR, 0.30 for hypertension; 0.45 for diabetes), and the next lowest in health screening specialized clinics (OR, 0.51 for hypertension; 0.46 for diabetes). Among individual-level variables, female sex, older age, higher insurance premium level, and residing in cities were positively associated with adherence in both the hypertension and diabetes samples. Conclusions This study showed that the prescribing institution had a significant relationship with medication adherence. When the first prescribing institution was a clinic, newly diagnosed patients were more likely to adhere to their medication. These results highlight the important role played by primary care institutions in managing mild chronic diseases.
Uneven Human Capital Development in Contemporary China: A Non-monetary Perspective on Regional and Gender Inequality

Regional inequality is one of the most challenging issues facing China in the coming decade. Whilst this matter can be approached from different angles; mainstream scholars have tended to examine this issue by way of monetary measurement (e.g. GDP or income per capita). This study draws attention to the non-monetary aspect in order to shed new light on regional inequality. Accordingly, this research focuses on the gaps and trends of human capital development, a key non-monetary index proxying for regional inequality in transitional China. Taking education and health status as two key indicators, in particular, this research aims to trace the trends in regional inequality over the last two decades, investigate to what extent those two dimensions can help to identify and integrate factors behind regional disparities, and to analyse some profound policies and implications. Based upon official educational and health status statistics at provincial level, this study develops a model to exam regional disparity between the three economic development zones from 1990 to 2005. Main findings are that different perspectives of regional inequality bring out different consequences; from the viewpoint of human capital development, regional inequality presents positive findings in uneven development. Secondly, causes of development are fairly diverse and different measurements may significantly vary outcomes. Thirdly, uneven development is a spontaneous phenomenon underlying development, which over varying lengths of time may have stimulated economic growth in a positive way. Finally, limitations are discussed associated with policy implications.
Associations Between Head Injury and Subsequent Risk of Falls

Background and Objectives Falls are a leading cause of head injury among older adults, but the risk of fall occurring after a head injury is less well-characterized. We sought to examine the association between head injury and subsequent risk of falls requiring hospital care among community-dwelling older adults. Methods This analysis included 13,081 participants in the Atherosclerosis Risk in Communities Study enrolled in 1987–1989 and followed through 2019. The association of head injury (time-varying exposure, self-reported and/or ICD-9/10 code identified) with the risk of subsequent (occurring >1-month after head injury) falls requiring hospital care (ICD-9/10 code defined) was modeled using Cox proportional hazards regression. Secondary analyses included Fine and Gray proportional hazards regression to account for the competing risk of death, analysis of head injury frequency and severity, and formal testing for interaction by age, sex, and race. Models were adjusted for age, sex, race/center, education, military service, alcohol consumption, smoking, diabetes, hypertension, and psychotropic medication use. Results The mean age of participants at baseline was 54 years, 58% were female, 28% were Black, and 14% had at least one head injury occurring over the study period. Over a median 23 years of follow-up, 29% of participants had a fall requiring medical care. In adjusted Cox proportional hazards models, individuals with head injury had 2.01 (95% CI 1.85–2.18) times the risk of falls compared with individuals without head injury. Accounting for the competing risk of mortality, individuals with head injury had 1.69 (95% CI 1.57–1.82) times the risk of falls compared with individuals without head injury. We observed stronger associations among men compared with women (men: hazard ratio [HR] = 2.60, 95% CI 2.25–3.00; women: HR = 1.80, 95% CI 1.63–1.99, p-interaction <0.001). We observed evidence of a dose-response association for head injury number and severity with fall risk (1 injury: HR = 1.68, 95% CI 1.53–1.84; 2+ injuries: HR = 2.37, 95% CI 1.92–2.94 and mild: HR = 1.97, 95% CI 1.78–2.18; moderate/severe/penetrating: HR = 2.50, 95% CI 2.06–3.02). Discussion Among community-dwelling older adults followed over 30 years, head injury was associated with subsequent falls requiring medical care. We observed stronger associations among men and with increasing number and severity of head injuries. Whether older individuals with head injury might benefit from fall prevention measures should be a focus of future research.
Effects of different grazing intensities of sheep on accumulated particulate organic matter (POM) and organic matter mineralization in low-alpine grassland soils in Norway

Summer farming in mountain areas of Norway (e.g. livestock grazing and logging of fire wood) has reduced during the last century; however the number of sheep stayed relatively unchanged implying a translocation of grazing impact. Herbivores may affect both vegetation dynamics and nutrient cycling. Much information exists about the impact of cession of grazing, but little is known about the ecological effect of different grazing intensities. Using a controlled grazing experiment organized as total randomized block design (starting 2001), with three levels of grazing intensities by sheep (high, low and no sheep), effects of different grazing pressure on soil organic matter (SOM) mineralization and amount and quality of POM was studied in a low alpine region of Southern Norway. In a parallel study in situ measurements were conducted to determine biomass production rate and the quality of litter input. Soil samples from the O-horizon were incubated (determining C and N mineralization) and fractionated (free light POM fraction, density <1,8 g cm-3, size 20-2000 μm). It was hypothesized that high levels of grazing would induce (1) higher C and N mineralization rates and (2) less POM, due to physical (trampling) and chemical (input of faeces and urea) impact of sheep in addition to observed changes in vegetation cover.
Optimization with pattern-avoiding input

Permutation pattern-avoidance is a central concept of both enumerative and extremal combinatorics. In this paper we study the effect of permutation pattern-avoidance on the complexity of optimization problems. In the context of the dynamic optimality conjecture (Sleator, Tarjan, STOC 1983), Chalermsook, Goswami, Kozma, Mehlhorn, and Saranurak (FOCS 2015) conjectured that the amortized access cost of an optimal binary search tree (BST) is $O(1)$ whenever the access sequence avoids some fixed pattern. They showed a bound of $2^{\alpha{(n)}^{O(1)}}$, which was recently improved to $2^{\alpha{(n)}(1+o(1))}$ by Chalermsook, Pettie, and Yingchareonthawornchai (2023); here $n$ is the BST size and $\alpha(\cdot)$ the inverse-Ackermann function. In this paper we resolve the conjecture, showing a tight $O(1)$ bound. This indicates a barrier to dynamic optimality: any candidate online BST (e.g., splay trees or greedy trees) must match this optimum, but current analysis techniques only give superconstant bounds. More broadly, we argue that the easiness of pattern-avoiding input is a general phenomenon, not limited to BSTs or even to data structures. To illustrate this, we show that when the input avoids an arbitrary, fixed, a priori unknown pattern, one can efficiently compute a $k$-server solution of $n$ requests from a unit interval, with total cost $n^{O(1/\log k)}$, in contrast to the worst-case $\Theta(n/k)$ bound; and a traveling salesman tour of $n$ points from a unit box, of length $O(\log{n})$, in contrast to the worst-case $\Theta(\sqrt{n})$ bound; similar results hold for the euclidean minimum spanning tree, Steiner tree, and nearest-neighbor graphs. We show both results to be tight. Our techniques build on the Marcus-Tardos proof of the Stanley-Wilf conjecture, and on the recently emerging concept of twin-width; we believe our techniques to be more generally applicable.
Estimating Astrophysical Population Properties using a multi-component Stochastic Gravitational-Wave Background Search

The recent start of the fourth observing run of the LIGO-Virgo-KAGRA (LVK) collaboration has reopened the hunt for gravitational-wave (GW) signals, with one compact-binary-coalescence (CBC) signal expected to be observed every few days. Among the signals that could be detected for the first time there is the stochastic gravitational-wave background (SGWB) from the superposition of unresolvable GW signals that cannot be detected individually. In fact, multiple SGWBs are likely to arise given the variety of sources, making it crucial to identify the dominant components and assess their origin. However, most search methods with ground-based detectors assume the presence of one SGWB component at a time, which could lead to biased results in estimating its spectral shape if multiple SGWBs exist. Therefore, a joint estimate of the components is necessary. In this work, we adapt such an approach and analyse the data from the first three LVK observing runs, searching for a multi-component isotropic SGWB. We do not find evidence for any SGWB and establish upper limits on the dimensionless energy parameter $\Omega_{\rm gw}(f)$ at 25 Hz for five different power-law spectral indices, $\alpha = 0, \, 2/3,\, 2,\, 3,\, 4$, jointly. For the spectral indices $\alpha = 2/3,\, 2, \, 4$, corresponding to astrophysical SGWBs from CBCs, r-mode instabilities in young rotating neutron stars, and magnetars, we draw further astrophysical implications by constraining the ensemble parameters $K_{\rm CBC}, \, K_{\rm r-modes}, \, K_{\rm magnetars}$, defined in the main text.
School and weekend physical activity of 15-16 year-old Czech, Slovak and Polish adolescents

Background: When it comes to physical activity, adolescents are the group at the highest risk. When monitoring physical activity in adolescents, it is necessary to differentiate school and weekend days. School days are crucial in adolescents' weekly physical activity. Objective: The aim of the study is to identify to what extent the school day and weekend physical activity levels differ in Czech, Polish and Slovakian boys and girls with different cultural and education backgrounds in Central Europe. Methods: The research was carried out in the Czech Republic in Moravia (11 schools, 383 participants), in Poland in the Katowice region (11 schools, 327 participants) and in Slovakia in the Presov region (8 schools, 252 participants). In total, 421 boys and 541 girls participated in the study. Participants wore YAMAX pedometers for seven days and recorded measured values onto a record sheet and into the internet Indares system. The results were processed using repeated ANOVA analyses and contingent charts. Results: Czech, Polish, and Slovak boys and girls showed a significantly higher number of steps on school days than on weekend days. No difference between boys and girls was found on any day of the week in any of the states. The lowest number of steps was found, both in girls and boys, on Sundays. The highest number of daily steps was measured in Czech boys (n = 14015 steps * day-1), Polish girls (n = 12074 steps * day-1) and Slovakian girls (n = 12040 steps * day-1) on Fridays. Conclusions: Boys and girls in all three states were more physically active on school days than on weekend days. Wearing pedometers eliminated the differences between weekly physical activity in boys and girls in the Czech Republic, Poland and in Slovakia. Under Central European conditions, it was proven that wearing pedometers positively influences physical activity in girls.
HoloFed: Environment-Adaptive Positioning via Multi-Band Reconfigurable Holographic Surfaces and Federated Learning

Positioning is an essential service for various applications and is expected to be integrated with existing communication infrastructures in 5G and 6G. Though current Wi-Fi and cellular base stations (BSs) can be used to support this integration, the resulting precision is unsatisfactory due to the lack of precise control of the wireless signals. Recently, BSs adopting reconfigurable holographic surfaces (RHSs) have been advocated for positioning as RHSs’ large number of antenna elements enable generation of arbitrary and highly-focused signal beam patterns. However, existing designs face two major challenges: i) RHSs only have limited operating bandwidth, and ii) the positioning methods cannot adapt to the diverse environments encountered in practice. To overcome these challenges, we present HoloFed, a system providing high-precision environment-adaptive user positioning services by exploiting multi-band (MB)-RHS and federated learning (FL). For improving the positioning performance, a lower bound on the error variance is obtained and utilized for guiding MB-RHS’s digital and analog beamforming design. For better adaptability while preserving privacy, an FL framework is proposed for users to collaboratively train a position estimator, where we exploit the transfer learning technique to handle the lack of position labels of the users. Moreover, a scheduling algorithm for the BS to select which users train the position estimator is designed, jointly considering the convergence and efficiency of FL. Our performance evaluation based on simulations confirms that HoloFed achieves a 57% lower positioning error variance compared to a beam-scanning baseline and can effectively adapt to diverse environments.
Neural Impostor: Editing Neural Radiance Fields with Explicit Shape Manipulation

Neural Radiance Fields (NeRF) have significantly advanced the generation of highly realistic and expressive 3D scenes. However, the task of editing NeRF, particularly in terms of geometry modification, poses a significant challenge. This issue has obstructed NeRF's wider adoption across various applications. To tackle the problem of efficiently editing neural implicit fields, we introduce Neural Impostor, a hybrid representation incorporating an explicit tetrahedral mesh alongside a multigrid implicit field designated for each tetrahedron within the explicit mesh. Our framework bridges the explicit shape manipulation and the geometric editing of implicit fields by utilizing multigrid barycentric coordinate encoding, thus offering a pragmatic solution to deform, composite, and generate neural implicit fields while maintaining a complex volumetric appearance. Furthermore, we propose a comprehensive pipeline for editing neural implicit fields based on a set of explicit geometric editing operations. We show the robustness and adaptability of our system through diverse examples and experiments, including the editing of both synthetic objects and real captured data. Finally, we demonstrate the authoring process of a hybrid synthetic‐captured object utilizing a variety of editing operations, underlining the transformative potential of Neural Impostor in the field of 3D content creation and manipulation.