Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of deep transverse friction massage vs stretching on football players’ performance

BACKGROUND Flexibility, agility and muscle strength are key factors to either win or lose a game. Recently the effect of a new technique, deep transverse friction massage (DTFM) on muscle extensibility as compared to traditional stretching techniques has been examined. AIM To compare the effect of DTFM vs static and dynamic stretching techniques on the hamstring’s extensibility, agility, and strength amongst Lebanese and Syrian football players. Recording the incidence of non-contact hamstring muscle injury was a secondary objective. METHODS This study is a single-blinded prospective longitudinal randomized controlled trial. The experiment took place over a period of four weeks. Football players were randomized into three intervention groups (static stretching; dynamic stretching; DTFM). Participants of each group were followed-up carefully by assessors during their intervention sessions three times per week, for a total of 12 sessions and during the data collection. Extensibility, agility, and strength were compared between intervention groups at (baseline; acute; and chronic) phases. Straight leg raise and 1 repetition maximum tests were used to measure the dominant leg hamstring muscle extensibility and maximal strength respectively. T-drill test was used to assess the lower extremities agility. RESULTS Of 103 Lebanese and Syrian male football players aged between 18 and 35 were sampled from Damascus-Syria and South of Lebanon to participate in this study. Between-groups measures of acute strength (P = 0.011) and chronic extensibility (P = 0.000) solely showed a significant difference, and the static group showed to be superior as compared to the other groups. No loss to follow-up or protocol violation was recorded. CONCLUSION Static stretching is showing to be superior to the other techniques used, regarding gaining long-term extensibility and short-term maximal muscle strength. In addition, DTFM showed improvements but did not outweigh the effects on footballers’ performance when comparing it to static and dynamic techniques. Finally, no difference between the interventions is recorded regarding the rate of muscle injuries incidence.
Regulation of lncRNA PVT1 on miR-125 in metastasis of gastric cancer cells

Regulation of long non-coding RNA (lncRNA) PVT1 on miR-125 affecting the metastasis of gastric cancer cells and the mechanism were investigated. qPCR was used to detect the expression of PVT1 and miR-125 in gastric cancer and paracancerous tissues, and the relationship between PVT1 and clinicopathological parameters of gastric cancer patients. Dual luciferase reporter gene was used to detect the mutual effect between PVT1 and miR-125. The clone formation assay was used to detect changes of proliferation behavior of gastric cancer cells after inhibition of PVT1. Transwell invasion assay was used to detect the changes of invasion ability of gastric cancer cells after inhibition of PVT1. Subcutaneous tumor formation in nude mice inhibited the effect of PVT1 on the tumor size and volume of gastric cancer cells. Compared with paracancerous tissues, the expression of PVT1 and miR-125 was significantly increased in gastric cancer tissues. There were no significant differences in the expression level of PVT1 between gastric cancer patients of different genders and ages. The higher the gastric cancer staging was, the more obvious the expression level of PVT1 in the tissues of patients with gastric cancer was, and the more obvious the expression of PVT1 in the tissues of patients with gastric lymph node metastasis was. PVT1 specifically bound to the 3′UTR of miR-125, whereas the inhibition of PVT1 inhibited the ability of proliferation and invasion of gastric cancer cells. In vitro experiment of tumor formation in nude mice showed that the tumor volume and weight of the tumor-bearing mice in the si-PVT1 group were significantly reduced. PVT1 plays an important role in the occurrence and development of gastric cancer, it can regulate the proliferation and invasion of gastric cancer cells by targeting miR-125 activity.
Biology and pathogenesis of human osteosarcoma

Osteosarcoma (OS) is a bone tumor of mesenchymal origin, most frequently occurring during the rapid growth phase of long bones, and usually located in the epiphyseal growth plates of the femur or the tibia. Its most common feature is genome disorganization, aneuploidy with chromosomal alterations, deregulation of tumor suppressor genes and of the cell cycle, and an absence of DNA repair. This suggests the involvement of surveillance failures, DNA repair or apoptosis control during osteogenesis, allowing the survival of cells which have undergone alterations during differentiation. Epigenetic events, including DNA methylation, histone modifications, nucleosome remodeling and expression of non-coding RNAs have been identified as possible risk factors for the tumor. It has been reported that p53 target genes or those genes that have their activity modulated by p53, in addition to other tumor suppressor genes, are silenced in OS-derived cell lines by hypermethylation of their promoters. In osteogenesis, osteoblasts are formed from pluripotent mesenchymal cells, with potential for self-renewal, proliferation and differentiation into various cell types. This involves complex signaling pathways and multiple factors. Any disturbance in this process can cause deregulation of the differentiation and proliferation of these cells, leading to the malignant phenotype. Therefore, the origin of OS seems to be multifactorial, involving the deregulation of differentiation of mesenchymal cells and tumor suppressor genes, activation of oncogenes, epigenetic events and the production of cytokines.
PD-L1 gene promoter methylation represents a potential diagnostic marker in advanced gastric cancer

Gastric cancer is one of the most prevalent malignant tumors worldwide. Immunological checkpoint inhibitors of the programmed death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signaling pathway are effective in the treatment of various malignant tumor types, but the potential of such immunotherapeutic techniques for the treatment of gastric cancer is yet to be elucidated. The purpose of the present study was to investigate the methylation of the PD-L1 gene promoter and its clinical significance in advanced gastric cancer, as this may suggest the use of PD-L1 promoter methylation as a novel biomarker for gastric cancer progression. In a total of 70 samples, the methylation rate of the PD-L1 gene promoter region was significantly higher in gastric cancer tissues compared with adjacent tissues. A high level of PD-L1 promoter methylation was associated with lymph node staging, and resulted in poorer prognoses in patients with advanced gastric cancer. A total of 26 patients exhibited highly methylated PD-L1; in this group, the median progression-free survival time of patients receiving platinum/fluorouracil chemotherapy was 4.2 months longer than those receiving paclitaxel/fluorouracil chemotherapy, and the risk of disease progression in patients receiving paclitaxel/fluorouracil chemotherapy was 5.009 times higher compared with patients who received platinum/fluorouracil chemotherapy. Additionally, PD-L1 promoter methylation was significantly correlated with PD-L1 expression, and the progression of advanced gastric cancer. In conclusion, high methylation levels of the PD-L1 promoter region may be a faciliatory mechanism enabling gastric cancer tumorigenesis, and may also represent an independent prognostic factor for chemotherapeutic efficacy in patients with advanced gastric cancer.
Clinical characteristics of neuropathic pain in leprosy and associated somatosensory profiles: a deep phenotyping study in India

Abstract This study investigated the clinical characteristics and somatosensory profiles of patients suffering from leprosy in Mumbai, India. A cross-sectional deep profiling study was conducted in 86 patients with leprosy (with and without pain) using an extensive battery of phenotyping measures including structured clinical examination, psychological state (General Health Questionnaire [GHQ-12]), and a quality-of-life condition-specific instrument (Brief Pain Inventory—short form). Quantitative sensory testing was performed according to the protocol of the German Research Network on Neuropathic Pain (DFNS) to assess the somatosensory profiles in the ulnar nerve innervation territory of all participants (dorsum of the hand). Reference data from 50 healthy Indian subjects were within the range of published DFNS values. Somatosensory profiles in leprosy patients with clinically or electroneurographically diagnosed neuropathy (with and without pain) revealed a profile of sensory loss to thermal and tactile stimuli combined with preservation of vibration and deep pressure detection. Sensory gain phenomena were not generally observed in patients with leprosy. In the group of subclinical neuropathy, a high degree of impaired thermal sensation was found, which could be clinically deployed to enhance identification of leprosy neuropathy at an early stage. Quantitative sensory testing can effectively document leprosy-associated neuropathy but does not distinguish between patients with or without pain. Patients with leprosy and neuropathic pain reported a poor quality of life and less psychological well-being compared with the pain-free patients with leprosy neuropathy.
Application of deep learning to the classification of uterine cervical squamous epithelial lesion from colposcopy images combined with HPV types

The aim of the present study was to explore the feasibility of using deep learning, such as artificial intelligence (AI), to classify cervical squamous epithelial lesions (SILs) from colposcopy images combined with human papilloma virus (HPV) types. Among 330 patients who underwent colposcopy and biopsy performed by gynecological oncologists, a total of 253 patients with confirmed HPV typing tests were enrolled in the present study. Of these patients, 210 were diagnosed with high-grade SIL (HSIL) and 43 were diagnosed with low-grade SIL (LSIL). An original AI classifier with a convolutional neural network catenating with an HPV tensor was developed and trained. The accuracy of the AI classifier and gynecological oncologists was 0.941 and 0.843, respectively. The AI classifier performed better compared with the oncologists, although not significantly. The sensitivity, specificity, positive predictive value, negative predictive value, Youden's J index and the area under the receiver-operating characteristic curve ± standard error for AI colposcopy combined with HPV types and pathological results were 0.956 (43/45), 0.833 (5/6), 0.977 (43/44), 0.714 (5/7), 0.789 and 0.963±0.026, respectively. Although further study is required, the clinical use of AI for the classification of HSIL/LSIL by both colposcopy and HPV type may be feasible.
Higher Cardiorespiratory Fitness is Associated with Reduced Functional Brain Connectivity During Performance of the Stroop Task

Background: Although higher cardiorespiratory fitness (CRF) has been linked to better executive function, the mechanisms by which this occurs remain a matter of speculation. One hypothesis is that higher CRF is associated with elevated top-down control in which brain regions processing task-relevant information are up-regulated and brain regions processing task-irrelevant information are down-regulated. Methods: We tested this top-down hypothesis in 50 young adults (μ age = 25.22 ± 5.17 years) by measuring CRF via a graded maximal exercise test and performing functional Magnetic Resonance Imaging (fMRI) during a color-word Stroop task. We used task-evoked functional connectivity, quantified from a psychophysiological interaction analysis (PPI), to test our hypotheses that (a) higher CRF would be associated with greater connectivity between control centers (i.e., prefrontal and parietal areas) and visual feature centers (i.e., occipital areas) that are involved with processing task-relevant stimulus dimensions (i.e., color), and (b) higher CRF would be associated with lower connectivity between control centers and visual feature centers that are involved with processing task-irrelevant dimensions of the stimuli (i.e., word processing areas). Results: Controlling for sex and BMI, we found, consistent with our second hypothesis, that higher CRF was associated with reduced functional connectivity between parietal and occipital areas involved in the task-irrelevant dimension of the task (i.e., word form areas). There were no associations between CRF and functional connectivity with the prefrontal cortex or evidence of heightened connectivity between attentional control and visual feature centers. Conclusions: These results suggest that CRF associations with executive functioning might be explained by CRF-mediated differences between brain regions involved with attentional control (parietal regions) and the down-regulation of regions involved with processing task-irrelevant stimulus features (occipital regions).
A systematic review of western medicine's understanding of pain experience, expression, assessment, and management for Australian Aboriginal and Torres Strait Islander Peoples

Abstract Although pain is a near-universal experience, pain expression and beliefs are highly variable and can affect assessment and management of pain. This systematic review seeks to synthesize the research findings regarding pain management for Australian Aboriginal and Torres Strait Islander peoples addressing variation as voiced by patients, clinicians, and researchers alike. A systematic review was performed across 7 research databases for all articles related to pain within Indigenous Australian peoples. Additional literature was identified by hand-searching reference lists. Articles were restricted to literature which addressed pain within Indigenous Australians as the primary focus of the article. Thematic analysis was performed to group articles according to those which focussed on the experience, expression, assessment, or management of pain. A total of 294 articles were identified on initial search of literature, of which 20 met inclusion criteria for this study. This review captured gross heterogeneity in cohorts, research methodologies, and conditions studied, making generalized assumptions impossible and inappropriate. Studies suggest that the beliefs of both patients and practitioners are important considerations in approaching effective assessment and management of pain. Health practitioners should appreciate how our own beliefs influence the management of patients and must ensure community consultation is undertaken in order to improve pain assessment and management.
Capture by Context Elements, Not Attentional Suppression of Distractors, Explains the PD with Small Search Displays

Abstract Top–down control of attention allows us to resist attentional capture by salient stimuli that are irrelevant to our current goals. Recently, it was proposed that attentional suppression of salient distractors contributes to top–down control by biasing attention away from the distractor. With small search displays, attentional suppression of salient distractors may even result in reduced RTs on distractor-present trials. In support of attentional suppression, electrophysiological measures revealed a positivity between 200 and 300 msec contralateral to the distractor, which has been referred to as distractor positivity (PD). We reexamined distractor benefits with small search displays and found that the positivity to the distractor was followed by a negativity to the distractor. The negativity, referred to as N2pc, is considered an index of attentional selection of the contralateral element. Thus, attentional suppression of the distractor (PD) preceded attentional capture (N2pc) by the distractor, which is at odds with the idea that attentional suppression avoids attentional capture by the distractor. Instead, we suggest that the initial “PD” is not a positivity to the distractor but rather a negativity (N2pc) to the contralateral context element, suggesting that, initially, the context captured attention. Subsequently, the distractor was selected because, paradoxically, participants searched all lateral target positions (even when irrelevant) before they examined the vertical positions. Consistent with this idea, search times were shorter for lateral than vertical targets. In summary, the early voltage difference in small search displays is unrelated to distractor suppression but may reflect capture by the context.
Elective single blastocyst transfer reduces twin rates without compromising pregnancy rates

To compare IVF outcome in single versus two blastocyst transfer in good-prognosis patients. Design: Retrospective data analysis. Setting: University-based IVF practice. Patient(s): Assisted reproductive technology outcome was compared in 41 patients who underwent elective single blastocyst transfer and 66 patients who underwent two blastocyst transfer. Intervention(s): None. Main Outcome Measure(s): Implantation rates, clinical pregnancy rates, cumulative pregnancy rates, twin pregnancy rates. Result(s): Blastocyst cycles between January 2003 and August 2004 (n = 238) were reviewed. Criteria for elective single embryo transfer established by our clinic were applied retrospectively to blastocyst cycles. Patients who met the criteria were divided into two groups, those who underwent elective single embryo transfer (eSET)-and those who underwent two embryo transfer (2ET). Patient and cycle characteristics were similar for both groups. There were no differences in implantation rate (76% vs. 66% ) or pregnancy rate (76% vs. 79% ) between the eSET and 2ET groups. There was a significant difference in the number of twin pregnancies (3.2% vs. 62% ) in the eSET versus 2ET group. Cumulative pregnancy rates were found to be 83% for both groups. Conclusion(s): Single blastocyst transfer can be performed in good-prognosis patients without compromising pregnancy rates. Twin pregnancy rates can be significantly reduced with eSET.
Deconstructing Reorienting of Attention: Cue Predictiveness Modulates the Inhibition of the No-target Side and the Hemispheric Distribution of the P1 Response to Invalid Targets

Abstract Orienting of attention produces a “sensory gain” in the processing of visual targets at attended locations and an increase in the amplitude of target-related P1 and N1 ERPs. P1 marks gain reduction at unattended locations; N1 marks gain enhancement at attended ones. Lateral targets that are preceded by valid cues also evoke a larger P1 over the hemisphere contralateral to the no-target side, which reflects inhibition of this side of space [Slagter, H. A. , Prinssen, S. , Reteig, L. C. , & Mazaheri, A. Facilitation and inhibition in attention: Functional dissociation of pre-stimulus alpha activity, P1, and N1 components. Neuroimage, 125, 25–35, 2016]. To clarify the relationships among cue predictiveness, sensory gain, and the inhibitory P1 response, we compared cue- and target-related ERPs among valid, neutral, and invalid trials with predictive (80% valid/20% invalid) or nonpredictive (50% valid/50% invalid) directional cues. Preparatory facilitation over the visual cortex contralateral to the cued side of space (lateral directing attention positivity component) was reduced during nonpredictive cueing. With predictive cues, the target-related inhibitory P1 was larger over the hemisphere contralateral to the no-target side not only in response to valid but also in response to neutral and invalid targets: This result highlights a default inhibitory hemispheric asymmetry that is independent from cued orienting of attention. With nonpredictive cues, valid targets reduced the amplitude of the inhibitory P1 over the hemisphere contralateral to the no-target side whereas invalid targets enhanced the amplitude of the same inhibitory component. Enhanced inhibition was matched with speeded reorienting to invalid targets and drop in attentional costs. These findings show that reorienting of attention is modulated by the combination of cue-related facilitatory and target-related inhibitory activity.
GLIB: Exploration via Goal-Literal Babbling for Lifted Operator Learning

We address the problem of efficient exploration for learning lifted operators in sequential decision-making problems without extrinsic goals or rewards. Inspired by human curiosity, we propose goal-literal babbling (GLIB), a simple and general method for exploration in such problems. GLIB samples goals that are conjunctions of literals, which can be understood as specific, targeted effects that the agent would like to achieve in the world, and plans to achieve these goals using the operators being learned. We conduct a case study to elucidate two key benefits of GLIB: robustness to overly general preconditions and efficient exploration in domains with effects at long horizons. We also provide theoretical guarantees and further empirical results, finding GLIB to be effective on a range of benchmark planning tasks.
A multiplicity study of transiting exoplanet host stars

Context. Many main-sequence stars are part of multiple systems. The effect of stellar multiplicity on planet formation and migration, however, is poorly understood. Aims. We study the multiplicity of stars hosting known transiting extra-solar planets to test competing theories on the formation mechanisms of hot Jupiters. Methods. We observed 45 exoplanet host stars using the infrared dual imaging spectrograph of the Spectro-Polarimetric High-Contrast Exoplanet Research (SPHERE) instrument at the Very Large Telescope to search for potential companions. For each identified candidate companion we determined the probability that it is gravitationally bound to its host by performing common proper motion checks and modelling of synthetic stellar populations around the host. In addition, we derived contrast limits as a function of angular separation to set upper limits on further companions in these systems. We converted the derived contrast into mass thresholds using AMES-Cond, AMES-Dusty, and BT-Settl models. Results. We detected new candidate companions around K2-38, WASP-72, WASP-80, WASP-87, WASP-88, WASP-108, WASP-118, WASP-120, WASP-122, WASP123, WASP-130, WASP-131, and WASP-137. The closest candidates were detected at separations of 0. ′′124±0. ′′007 and 0. ′′189±0. ′′003 around WASP-108 and WASP-131; the measured K-band contrasts indicate that these are stellar companions of 0.35 ± 0.02 M⊙ and 0.62−0.04+0.05 M⊙, respectively. Including the re-detection and confirmation of previously known companions in 13 other systems, we derived a multiplicity fraction of 55.4−9.4+5.9%. For the representative sub-sample of 40 hot Jupiter host stars among our targets, the derived multiplicity rate is 54.8−9.9+6.3%. Our data do not confirm any trend that systems with eccentric planetary companions are preferably part of multiple systems. On average, we reached a magnitude contrast of 8.5 ± 0.9 mag at an angular separation of 0. ′′5. This allows us to exclude additional stellar companions with masses higher than 0.08M⊙ for almost all observed systems; around the closest and youngest systems, this sensitivity is achieved at physical separations as small as 10 au. Conclusions. Our study shows that SPHERE is an ideal instrument for detecting and characterising close companions to exoplanetary host stars. Although the second data release of the Gaia mission also provides useful constraints for some of the systems, the achieved sensitivity provided by the current data release of this mission is not good enough to measure parallaxes and proper motions for all detected candidates. For 14 identified companion candidates further astrometric epochs are required to confirm their common proper motion at 5σ significance.