Miracle-dz/UniFAR-FTUs huggingface dataset:
ORAL RUTIN SUSPENSION INTERVENE IN HEPATIC HYPERPLASIA IN RATS.

BACKGROUND Rutin is a flavonol glycoside that can be found in a wide variety of vegetables and has activity, anti-cancer, anti-inflammatory and anti-diabetic properties. OBJECTIVE This study investigated the effect of rutin oral administration on Wistar rats submitted to hepatic hyperplasia after partial hepatectomy (PH). METHODS To achieve this, we considered the analysis of hepatic hyperplastic and plasma biochemical activity of Wistar rats, subjected to treatment with rutin 40 mg/kg/day for 10 days in group 1 (G1) or saline in group 2 (G2), followed by partial hepatectomy. RESULTS The results indicated an increase in the number of mitoses after 24 hours and 48 hours (P=0.0022 and P=0.0152, respectively) of PH in the group that received rutin, as well as an increase in AST serum levels after 24 hours (P=0.0159) and 48 hours (P=0.0158) and alkaline phosphatase after 24 hours (P=0.015) in the same group, in relation to the respective controls. The group that received rutin showed a more evident variation than the control group when comparing the 24 hour and 48 hour results regarding AST, number of mitoses and number of apoptosis (P<0.005). CONCLUSION It was concluded that rutin intervened in hepatic hyperplasia after 24 hours and 48 hours of PH, favoring hepatic hyperplasia.
Partners’ Relationship Mindfulness Promotes Better Daily Relationship Behaviours for Insecurely Attached Individuals

Attachment anxiety and avoidance are generally associated with detrimental relationship processes, including more negative and fewer positive relationship behaviours. However, recent theoretical and empirical evidence has shown that positive factors can buffer insecure attachment. We hypothesised that relationship mindfulness (RM)—open or receptive attention to and awareness of what is taking place internally and externally in a current relationship—may promote better day-to-day behaviour for both anxious and avoidant individuals, as mindfulness improves awareness of automatic responses, emotion regulation, and empathy. In a dyadic daily experience study, we found that, while an individual’s own daily RM did not buffer the effects of their own insecure attachment on same-day relationship behaviours, their partner’s daily RM did, particularly for attachment avoidance. Our findings for next-day relationship behaviours, on the other hand, showed that lower (vs. higher) prior-day RM was associated with higher positive partner behaviours on the following day for avoidant individuals and those with anxious partners, showing this may be an attempt to “make up” for the previous day. These findings support the Attachment Security Enhancement Model and have implications for examining different forms of mindfulness over time and for mindfulness training.
Childhood trauma is associated with elevated anhedonia and altered core reward circuitry in major depression patients and controls

Childhood trauma (CT) is a well‐established risk factor for major depressive disorder (MDD). However, the underlying mechanism linking CT and MDD remains not fully understood. The present study tested the hypothesis that CT have effects on specific types of anhedonia in depression via reward system. To do so, we evaluated different aspects of anhedonia and resting‐state functional connectivity (FC) in reward system among 66 patients with MDD (44 with moderate‐to‐severe and 22 with no or low CT), and 57 healthy controls (HC; 23 with moderate‐to‐severe and 34 with no or low CT). Results showed that MDD patients with moderate‐to‐severe CT suffered more severe state anhedonic depression than patients with no or low level of CT. Individuals with moderate‐to‐severe CT, irrespective of MDD diagnosis, had elevated physical, social and anticipatory but not consummatory trait anhedonia, and demonstrated decreased left nucleus accumbens (NAcc)‐right orbital frontal cortex (OFC) and left ventral caudate‐left OFC connectivity compared to those with no or low exposure. Left NAcc‐right OFC connectivity mediated relationship between CT and state anhedonia in MDD. The total altered ventral striatum (VS)‐OFC connectivity mediated links between CT and physical trait anhedonia in HC. These findings highlight specific types of anhedonia and the core reward system as targets of CT. Blunted hedonic responses via decreased coupling within core reward system may be involved in the mechanism of depression following CT. Implications for clinical interventions are also discussed.
Nanostructure ITO and Get More of It. Better Performance at Lower Cost

In this paper, we investigated how different growth conditions (i.e., temperature, growth time, and composition) allows for trading off cost (i.e., In content) and performance of nanostructured indium tin oxide (ITO) for biosensing applications. Next, we compared the behavior of these functionalized nanostructured surfaces obtained in different growth conditions between each other and with a standard thin film as a reference, observing improvements in effective detection area up to two orders of magnitude. This enhanced the biosensor’s sensitivity, with higher detection level, better accuracy and higher reproducibility. Results show that below 150 °C, the growth of ITO over the substrate forms a homogenous layer without any kind of nanostructuration. In contrast, at temperatures higher than 150 °C, a two-phase temperature-dependent growth was observed. We concluded that (i) nanowire length grows exponentially with temperature (activation energy 356 meV) and leads to optimal conditions in terms of both electroactive surface area and sensitivity at around 300 °C, (ii) longer times of growth than 30 min lead to larger active areas and (iii) the In content in a nanostructured film can be reduced by 10%, obtaining performances equivalent to those found in commercial flat-film ITO electrodes. In summary, this work shows how to produce appropriate materials with optimized cost and performances for different applications in biosensing.
Prevalence of inadequate intake of vitamins and minerals in the Mexican population correcting by nutrient retention factors, Ensanut 2016.

OBJECTIVE To estimate the usual intake and the prevalence of inadequacy of selected nutrients in the Mexican population and the potential effect that the nutrient retention factors (NRF) could have on these estimates. Likewise, document the methodology used in the analysis of the 24 hours of the mid-way National Health and Nutrition Survey 2016 (Ensanut MC 2016). MATERIALS AND METHODS Dietary information from the Ensanut MC 2016 was analyzed with and without the use of NRFs. RESULTS Results. Most nutrients evaluated showed a relevant inadequacy prevalence above 10% in all age groups. Likewise, we documented that, when NRFs were not applied, estimated intakes and prevalence were significantly under-estimated in a range of 2% to 55.5%. CONCLUSIONS We documented the relevance of the application of NRFs for adequate estimation of the prevalence of inadequate intake of selected nutrients in population studies.
Effect of Different Levels of Zinc on Blood Physiological and Biochemical Parameters in Stud Holstein Bulls

Thirty breeding Holstein bulls assigned randomly to five groups was conducted to study the effect of different levels of zinc on blood physiological and biochemical parameters.This experiment involved 5 dietary treatments with single factorial arrangement,consisting of one control group fed basal diet and four levels of zinc which is 50,80,110 and 200 mg/kg(by the dry matter of the dietary). The results showed that 1) the effect of different levels of zinc on the activity of GPT,GOT were extremely significant(P0.01),but that on AKP,LDH were not significant(P0.05);2) the effect of different levels of zinc on the testosterone contents in serum were extremely significant(P0.01),but that on zinc contents in serum was not significant(P0.05). All of the variety of physiological and biochemical parameters analysed in each group indicated that the optimal supplementation of zinc was 110 mg/kg by the dry matter in this experiment.
Role of Endoluminal Catheter Colonization Surveillance Cultures to Reduce Catheter-Related Blood Stream Infections in Hemodialysis Patients

Background: Central Venous Catheter (CVC) use as vascular access to the systemic circulation is highly vital for Hemodialysis (HD) patients. Catheter-related bloodstream infection (CRBSI) is the main complication of CVC use. Aim of the work: To assess the use of surveillance cultures (SCs) to prevent CRBSIs in asymptomatic HD patients. Patients and Methods: A prospective cohort study was conducted on eighteen HD patients with CVC, admitted to Dialysis Units of Benha University Hospitals and Meet Ghamr Nephrology and Urology Hospital during the period from October 2016 to March 2017. Endoluminal colonization of the catheter was assessed every 15 days by inoculating ~5 - 10 mL of endoluminal blood into aerobic blood culture bottles. Individual patients were triaged based on SC results: group 1 (negative); group 2 (coagulase-negative Staphylococcus [CoNS] with time-to-positivity (TTP) >14 hours); group 3 (CoNS with TTP ≤14 hours); and group 4 (any microorganism other than CoNS with any TTP or CoNS with Differential Time to Positivity (DTP) more than 120 minutes). Results: A total of 60 SCs were collected with a mean number per patient of 3.3. Of which 24 SCs (40%) were negative (group 1), and 36 SCs (60%) were positive (0 in group 2, 6 in group 3, and 30 in group 4). Under this protocol, the incidence density of CRBSI was 10.8 episodes per 1000 catheter days. Conclusion: SCs based on easily accessible samples proved useful in triaging HD patients at a high risk of infection.
Development of an Item Bank to Measure Medication Adherence: Systematic Review

Background Medication adherence is important in managing the progression of chronic diseases. A promising approach to reduce cognitive burden when measuring medication adherence lies in the use of computer‐adaptive tests (CATs) or in the development of shorter patient-reported outcome measures (PROMs). However, the lack of an item bank currently hampers this progress. Objective We aim to develop an item bank to measure general medication adherence. Methods Using the preferred reporting items for systematic review and meta-analysis (PRISMA), articles published before October 2019 were retrieved from PubMed, Embase, CINAHL, the Cochrane Library, and Web of Science. Items from existing PROMs were classified and selected (“binned” and “winnowed”) according to standards published by the Patient-Reported Outcomes Measurement Information System (PROMIS) Cooperative Group. Results A total of 126 unique PROMs were identified from 213 studies in 48 countries. Items from the literature review (47 PROMs with 579 items for which permission has been obtained) underwent binning and winnowing. This resulted in 421 candidate items (77 extent of adherence and 344 reasons for adherence). Conclusions We developed an item bank for measuring general medication adherence using items from validated PROMs. This will allow researchers to create new PROMs from selected items and provide the foundation to develop CATs.
Flowers in the Attic: Lateralization of the detection of meaning in visual noise

The brain is a slave to sense; we see and hear things that are not there and engage in ongoing correction of these illusory experiences, commonly termed pareidolia. The current study investigates whether the predisposition to see meaning in noise is lateralized to one hemisphere or the other and how this predisposition to visual false-alarms is related to personality. Stimuli consisted of images of faces or flowers embedded in pink (1/f) noise generated through a novel process and presented in a divided-field paradigm. Right-handed undergraduates participated in a forced-choice signal-detection task where they determined whether a face or flower signal was present in a single-interval trial. Experiment 1 involved an equal ratio of signal-to-noise trials; experiment 2 provided more potential for illusionary perception with 25% signal and 75% noise trials. There was no asymmetry in the ability to discriminate signal from noise trials (measured using d′) for either faces and flowers, although the response criterion (c) suggested a stronger predisposition to visual false alarms in the right visual field, and this was negatively correlated to the unusual experiences dimension of schizotypy. Counter to expectations, changing the signal-image to noise-image proportion in Experiment 2 did not change the number of false alarms for either faces and flowers, although a stronger bias was seen to the right visual field; sensitivity remained the same in both hemifields but there was a moderate positive correlation between cognitive disorganization and the bias (c) for “flower” judgements. Overall, these results were consistent with a rapid evidence-accumulation process of the kind described by a diffusion decision model mediating the task lateralized to the left-hemisphere.
Hypercapnia: An Aggravating Factor in Asthma

Asthma is a common chronic respiratory disorder with relatively good outcomes in the majority of patients with appropriate maintenance therapy. However, in a small minority, patients can experience severe asthma with respiratory failure and hypercapnia, necessitating intensive care unit admission. Hypercapnia occurs due to alveolar hypoventilation and insufficient removal of carbon dioxide (CO2) from the blood. Although mild hypercapnia is generally well tolerated in patients with asthma, there is accumulating evidence that elevated levels of CO2 can act as a gaso-signaling molecule, triggering deleterious effects in various organs such as the lung, skeletal muscles and the innate immune system. Here, we review recent advances on pathophysiological response to hypercapnia and discuss potential detrimental effects of hypercapnia in patients with asthma.
Performance of Galerucella calmariensis (Coleoptera: Chrysomelidae) on Different North American Populations of Purple Loosestrife

The success of a biological weed control program depends on the ability of control agents to develop on various genotypes of their host plants, thereby reducing the competitive ability of the target plant species. We studied the performance of the chrysomelid beetle Galerucella calmariensis L. , introduced as a biological control agent of purple loosestrife, Lythrum salicaria L. , on plants from 3 different North American populations. Plants for the experiments were obtained from Ithaca, NY; St. Paul, MN; and Salem, OR, representing different climates and colonization histories. We studied the survival and impact of G. calmariensis at 3 herbivore densities with plants grown under identical conditions at Ithaca. Plant growth and biomass allocation patterns were significantly different among the 3 tested populations. Survival rates of the leaf beetles (egg to adult) were not significantly different among sites or among herbivore attack levels. Herbivory caused significant reductions in plant height, leaf, shoot, root, and total plant biomass with increasing attack levels. We found no significant interaction of herbivory and plant origin. Plants compensated for the loss of photosynthetic tissues by replacing foliage at the expense of below ground storage, thus, herbivory altered the biomass allocation pattern of L. salicaria . This might have important implications for other control agents attacking the roots of L. salicaria .
Pharmacoepidemiology of Furosemide in the Neonatal Intensive Care Unit.

BACKGROUND Furosemide is commonly used off-label in the neonatal intensive care unit (NICU), but current dosing practices vary widely. OBJECTIVES To describe dosing practices including route, dose, and duration of exposure to furosemide in a large number of community and tertiary NICUs across North America. METHOD Using the Pediatrix Medical Group Clinical Data Warehouse, we identified infants who received ≥1 dose of furosemide between 1997 and 2016. We excluded infants with incomplete dosing data. We calculated average daily furosemide dose, cumulative dose, total days of exposure, and maximum daily dose. We compared dosing between infants born at <32 weeks gestational age (GA) and ≥32 weeks GA. RESULTS A total of 18,572 infants had complete dosing data. The median (interquartile value) postnatal age at first exposure was 11 days (4, 26), the median maximum daily dose was 1.0 mg/kg (0.97, 1.6), the median average daily dose was 1.0 mg/kg (0.88, 1.1), and the median cumulative dose was 2.0 mg/kg (1.0, 4.5). The median total duration of exposure was 2 days (1, 4). A total of 177 (1%) infants received ≥4 mg/kg/day of furosemide. Infants born <32 weeks GA were an older age at initial furosemide exposure compared to those born ≥32 weeks GA: 19 versus 4 days, p < 0.001. CONCLUSIONS Most infants received short courses of furosemide within the labeled dosing parameters. Further studies are needed to assess the safety and efficacy of furosemide in the NICU.
Reliability of Using the Proposed International Consensus Video Signs of Potential Concussion for National Rugby League Head Impact Events.

BACKGROUND Consensus on the definition of extant video signs of concussion have recently been proposed by representatives of international sporting codes for global consistency across professional leagues. OBJECTIVE To review the reliability of the proposed international consensus video signs of concussion in National Rugby League (NRL) head impact events (HIEs). METHODS The video signs of concussion were coded for every HIE during the 2019 NRL season. Coding was conducted blinded to the concussion status. Frequency, sensitivity, specificity, and a receiver operating characteristic curve were calculated. RESULTS There were 943 HIEs identified over the 2019 NRL season, of which 106 resulted in a diagnosed concussion. The most frequently observed video sign in concussed athletes was blank/vacant look (54%), which was also the most sensitive video sign (0.54, CI: 0.44-0.63), while the most specific was tonic posturing (0.99, CI: 0.99-1.00). In 43.4% of diagnosed concussions none of the 6 video signs were present. The 6 video signs demonstrated a "fair" ability to discriminate between concussion and nonconcussion HIEs (area under the curve = 0.76). CONCLUSION International consensus agreement between collision sports for extant video signs of concussion and the definition of those extant video signs are clinically important. The selection of signs requires rigorous assessment to examine their predictive value across all sports and within individual sports, and to determine further video signs to compliment and improve the identification of possible concussion events within various sports. The current study demonstrated that, for NRL-related HIEs, the diagnostic accuracy of video signs varies.
Metabolic acidosis exacerbates pyelonephritis in mice prone to vesicoureteral reflux

Acute pyelonephritis is a common, serious bacterial infection in children. The prevalence of acute pyelonephritis is due at least in part to vesicoureteral reflux (VUR). Although an association between abnormalities in electrolyte and acid–base balance and pyelonephritis is common in young children, the impact of metabolic acidosis (MA) on progression of acute pyelonephritis is not fully understood. In this study, the effect of MA on pyelonephritis was studied in C3H mouse strains prone to VUR. MA induced by ammonium chloride supplementation in food specifically impaired clearance of urinary tract infection with uropathogenic Escherichia. coli (UPEC‐UTI) in innate immune competent C3H strains (HeOuJ, HeN), whereas kidney UPEC burden in Tlr‐4‐deficient HeJ mice was unaffected. Antibody‐mediated depletion of myeloid cells (monocytes, neutrophil) markedly increased UPEC burden in the bladder and kidney confirming the pivotal role of neutrophils and tissue‐resident macrophages in clearance of UPEC‐UTI. MA concurrent with UPEC‐UTI markedly increased expression of cytokine (TNFα, IL‐1β, IL‐6) and chemokine (CXCL 1, 2, and 5) mRNA in isolated kidney CD cells and kidney neutrophil infiltrates were increased four‐ to fivefold compared to normal, UPEC‐infected mice. Thus, MA intensified pyelonephritis and increased the risk of kidney injury by impairing clearance of UPEC‐UTI and potentiating renal inflammation characterized by an elevated kidney neutrophil infiltrate.
Dissimilatory Nitrate Reduction to Ammonium and Responsible Microbes in Japanese Rice Paddy Soil

Nitrification–denitrification processes in the nitrogen cycle have been extensively examined in rice paddy soils. Nitrate is generally depleted in the reduced soil layer below the thin oxidized layer at the surface, and this may be attributed to high denitrification activity. In the present study, we investigated dissimilatory nitrate reduction to ammonium (DNRA), which competes with denitrification for nitrate, in order to challenge the conventional view of nitrogen cycling in paddy soils. We performed paddy soil microcosm experiments using 15N tracer analyses to assess DNRA and denitrification rates and conducted clone library analyses of transcripts of nitrite reductase genes (nrfA, nirS, and nirK) in order to identify the microbial populations carrying out these processes. The results obtained showed that DNRA occurred to a similar extent to denitrification and appeared to be enhanced by a nitrate limitation relative to organic carbon. We also demonstrated that different microbial taxa were responsible for these distinct processes. Based on these results and previous field observations, nitrate produced by nitrification within the surface oxidized layer may be reduced not only to gaseous N2 via denitrification, but also to NH4+ via DNRA, within the reduced layer. The present results also indicate that DNRA reduces N loss through denitrification and nitrate leaching and provides ammonium to rice roots in rice paddy fields.
Solution NMR readily reveals distinct structural folds and interactions in doubly 13C- and 19F-labeled RNAs

19F-13C spy couple enables NMR visualization of long-lived signals of large RNA structures, folds, and drug binding pockets. RNAs form critical components of biological processes implicated in human diseases, making them attractive for small-molecule therapeutics. Expanding the sites accessible to nuclear magnetic resonance (NMR) spectroscopy will provide atomic-level insights into RNA interactions. Here, we present an efficient strategy to introduce 19F-13C spin pairs into RNA by using a 5-fluorouridine-5′-triphosphate and T7 RNA polymerase–based in vitro transcription. Incorporating the 19F-13C label in two model RNAs produces linewidths that are twice as sharp as the commonly used 1H-13C spin pair. Furthermore, the high sensitivity of the 19F nucleus allows for clear delineation of helical and nonhelical regions as well as GU wobble and Watson-Crick base pairs. Last, the 19F-13C label enables rapid identification of a small-molecule binding pocket within human hepatitis B virus encapsidation signal epsilon (hHBV ε) RNA. We anticipate that the methods described herein will expand the size limitations of RNA NMR and aid with RNA-drug discovery efforts.