Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuromuscular Fatigue of Cycling Exercise in Hypoxia

Supplemental digital content is available in the text. ABSTRACT Introduction The understanding of fatigue in hypoxia is limited due to: lack of control in arterial saturation, different exercise intensities and hypoxia levels, lag time between exercise cessation and fatigue evaluation. We aimed at evaluating fatigue during cycling and immediately after exhaustion (EXH) in normoxia, moderate and severe hypoxia at relative and absolute intensities. Methods Thirteen subjects completed three sessions in normoxia, moderate, and severe hypoxia with intensity based on percentage of normoxic maximal power output (NOR, MODABS, SEVABS) plus two sessions where intensity was based on the corresponding environmental condition (MODREL, SEVREL). Arterial saturation was clamped at 85% and 70% in moderate and severe hypoxia, respectively. Before, during cycling, and at EXH, maximum voluntary contraction (MVC), peripheral fatigue (high-frequency doublet [Db100], twitch [Pt]), and central fatigue (cortical voluntary activation [VATMS]) were evaluated without delay using an innovative ergometer. Results Time to EXH declined not only with hypoxia level at absolute but also relative intensities compared to NOR. At isotime, MVC, Pt, and Db100 were similarly depreciated in NOR, MODREL, and SEVREL. At EXH, there was a similar reduction among conditions in MVC (−26% to −31%), Db100 (−25% to −35%) and VATMS (−9% to −13%). However, Pt was less decreased in SEVREL compared with NOR (−33% ± 17% vs –46% ± 16%). Conclusions The shorter time to EXH in relative hypoxia and yet lower peripheral fatigue and similar central fatigue compared with normoxia suggests that hypoxia per se may affect brain areas not directly implicated in quadriceps motor function.
Phytochemical profile of fennel essential oils and possible applications for natural antioxidant and controlling Convolvulus arvensis L

Abstract The natural compounds such as essential oils are getting more attention due to their potential usage in pharmaceuticals and possibly as natural herbicides. This study was conducted to identify the chemical compositions of essential oils from Foeniculum vulgare Mill. populations collected from different regions of Iran, Turkey, and Germany, and their antioxidant (DPPH·, ABTS·+ and reducing power methods) and phytotoxic activity (against Convolvulus arvensis L.). The results exhibited a significant variation in essential oils content (1.74-2.97%). The main compounds in essential oils were trans-anethole (15.23%−90.11%), estragole (4.00-63.72%), fenchone (0.03-12.62%) and limonene (1.05-13.04%). The results revealed that the essential oils have considerable antioxidant (IC50 values in the range of 11.83-36.90 mg mL−1 in DPPH, 7.65-20.13 mg mL−1 in ABTS·+ and EC50 values in the range of 3.65-15.24 mg mL−1 in reducing power assay) and phytotoxic activity. The results of this study can help in the development of natural antioxidants and herbicides.
Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis.

OBJECTIVES The conclusive prognostic significance of cyclo-oxygenase-2 has been determined in various cancers but not in nasopharyngeal carcinoma. Therefore, this study aimed to evaluate the relationship of cyclo-oxygenase-2 expression with the survival outcome and treatment response of nasopharyngeal carcinoma patients via a systematic meta-analysis approach. METHODS A meta-analysis was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses ('PRISMA') checklist. The primary clinical characteristics of patients, and hazard ratios with 95 per cent confidence intervals of overall survival data, were tabulated from eligible studies. The relationship of cyclo-oxygenase-2 expression with survival outcome (expressed as hazard ratio) and treatment response (expressed as odds ratio) in nasopharyngeal carcinoma patients was analysed, and explained with the aid of forest plot charts. RESULTS AND CONCLUSION The pooled hazard ratio for overall survival was 2.02 (95 per cent confidence interval = 1.65-2.47). This indicates that the over-expression of cyclo-oxygenase-2 is significantly associated with the poor survival of nasopharyngeal carcinoma patients. The pooled odds ratio of 0.98 (95 per cent confidence interval = 0.27-3.49) reveals that over-expression of cyclo-oxygenase-2 was not significantly related to the treatment outcome.
The Effectiveness of Cerclage Wiring on Stabilizing Intra-Operative Femoral Fractures During Cementless Total Hip Arthroplasty in Canines.

McCULLOCH, RYAN STERLING. The Effectiveness of Cerclage Wiring on Stabilizing Intra-Operative Femoral Fractures During Cementless Total Hip Arthroplasty in Canines. (Under the direction of Peter L. Mente and Simon C. Roe). Force is required to prepare the bone and achieve the initial press fit for an uncemented hip implant during Total Hip Arthroplasty (THA) surgery. In some situations, this force may cause of an intra-operative femoral fracture resulting in an unstable implant, subsidence, and pain for the patient. Many of the less extensive fractures can be repaired with cerclage wire or cables. This study aimed to evaluate the ability of double loop cerclage wire(s) to restore the stability of the implant-bone interface after a simulated intra-operative fracture. Nine femora from euthanized canine were harvested for in vitro testing. The femora were prepared for implantation of an uncemented femoral stem (BFXTM series, BioMedtrix, Boonton, NJ). They were then potted and mounted in a materials testing machine (MTS 858 Mini Bionix II, Eden Prairie, MN). The implant was driven to a clinically appropriate height, struck with 3 impacts (simulating seating hammer blows), and then the stem loaded to failure. Once a fracture occurred, the implant was extracted, the femur was repaired with appropriate cerclage, re-broached, and re-implanted. The repaired specimen was then tested in the same fashion as the intact bone. During loading, the displacement of the implant relative to the bone was measured using a linearly variable differential transformer (LVDT). The force to initiate subsidence, the peak force at failure, and the peak subsidence distance were compared between intact (pre-fracture) and repaired (post-fracture) specimens using ANOVA with blocking by specimen. The wired specimens demonstrated a higher force to initiate subsidence than the intact specimens (2378.8N ± 656.9N c.f. 1705.1N ± 584.5N; p= 0.0019). The wired specimens also sustained a higher peak force at failure than the intact specimens (3309.0N ± 609.14N c.f. 2276.3N ± 855.6N; p 0.0022). Furthermore, the wired specimens did not subside a significantly greater amount than the intact specimens (Intact: 3.90mm, SD 2.09mm; Wired: 6.71mm, SD 3.66mm; pvalue 0.0600). Cerclage wiring of intra-operative femoral fractures was able to restore the integrity of the femur and enable a stable implant-bone interface to be achieved. The Effectiveness of Cerclage Wiring on Stabilizing Intra-Operative Femoral Fractures During Cementless Total Hip Arthroplasty in Canines. by Ryan Sterling McCulloch A thesis submitted to the Graduate Faculty of North Carolina State University In partial fulfillment of the Requirements for the degree of Master of Science Biomedical Engineering Raleigh, North Carolina 2008
Diabetes distress, happiness, and its associated factors among type 2 diabetes mellitus patients with different therapies

Abstract This study aimed to investigate diabetes distress, happiness, and its associated factors of patients with type 2 diabetes mellitus (T2DM) treated by different therapies, and to analyze the related impact factors. A total of 1512 patients with T2DM were randomly selected from 18 tertiary hospitals in Hunan province from January 2016 to April 2016 who has been treated with oral antidiabetics monotherapy, insulin monotherapy, and combination therapy. Use the general information questionnaire, WHO-5 (the World Health Organization 5 well-being index) and PAID (the problem areas in diabetes scale) to collect the data. There are 846 (55.95%) patients that have serious emotional disorders, and the diabetes related distress in insulin treatment group was higher than that in combination treatment group (P < .05). Happiness of T2DM patients in combination therapy was higher than oral antidiabetic drug monotherapy and insulin monotherapy (P < .05). There was a negative correlation between diabetic suffering and happiness in patients with different treatments (R ranged from –0.335 to –0.436, P < .001). Age and happiness experience could explain 14.8% of the variance. Acute and chronic complications, controlled blood glucose level, lifestyle, therapies, and school education can explain 18.3% variance. Under different therapies, the suffering and happiness of T2DM patients differed from each other. The suffering and happiness of T2DM were related to different therapies, age, complications, glycaemic control, lifestyle, school education, and so on.
Prevention of systemic inflammation and neuroprotective effects of Qingda granules against angiotensin II-mediated hypertension.

Chinese yam is the dry rhizome of dioscoreaceae plant. Polysaccharide in yam is one of significant functional components, its pharmacological effects include glucose-lowering, lipid-lowering, anti-tumor, anti-oxidation and enhancing the immune. The effects of nano yam polysaccharide on the metabolism of blood glucose and blood lipid in model rats were systematically investigated in this study. The results showed that the diabetic rat model can been successfully induced by the peritoneal injection of 200mg/kg alloxan. The rats were fed with the high-fat diet for 30d, which could induce a model of hyperlipidemia rat successfully. After the model rats were fed with nano yam polysaccharide of 50mg/ml and 100mg/ml per day for 12d and 30d, respectively. For each nano yam polysaccharide group, the blood glucose level was significantly reduced, the glucose tolerance, glycogen and the content of C-peptide were improved in alloxan rats. Moreover, the symptom of one little and three more in diabetic rats was ameliorated and the contents of TC, TG and LDL-C in the serum for the high fat rats were significantly decreased.
Mechanical compression augments venous flow equal to intermittent pneumatic compression

Intermittent pneumatic compression is part of the current standard of care model for preventing venous thromboembolic events (VTE) after total joint arthroplasty. Pneumatic motors limit the rate of inflation resulting in bulky devices with uncomfortable sleeves that inhibited patient compliance and mobility. Nonpneumatic mechanical devices are an alternative for providing mobile, graded, intermittent, sequential, rapid, and monitorable compression posthospitalization. Fifteen healthy volunteers underwent mechanical compression using the Cirvo (Radial Medical, Mountain View, CA) as well as pneumatic compression with four commercially available systems (VenaFlow Elite, Kendall SCD Compression System, ActiveCare DVT, Vasculaire Compression System) and manual calf compression. Peak flow velocity (PFV) was measured by ultrasound of the femoral vein during compression and at baseline. Mechanical compression for 1 second resulted in a significant increase in femoral venous PFV to 107.8 ± 38.2 cm/s from 17.1 ± 4.7 cm/s at baseline (P < .001). The change in femoral venous PFV with mechanical compression for 1 second (90.7 ± 34.9 cm/s) was not statistically different from pneumatic compression from VenaFlow system (106.0 ± 35.6 cm/s, P = .124) and statistically lower than manual calf compression (115.5 ± 26.8 cm/s, P = .015). Pneumatic compression from the VenaFlow system produced the largest change in femoral venous PFV of all commercial pneumatic systems tested. Mechanical compression replicates or exceeds femoral venous PFV available from currently available intermittent pneumatic compression.
Bartonella in dogs and fleas from Tulancingo, Hidalgo, Mexico

Bartonella sp. infection is quite common in free‐roaming dogs in many tropical countries. However, limited information is available of the presence of these pathogens in Mexico. The present study looked at prevalence of Bartonella exposure and/or infection in dogs and their fleas in Central Mexico. Blood samples were collected from 31 stray dogs in August 2014 at the municipal pound, Tulancingo, Mexico, as well as fleas on 26 of them. Bartonella seropositivity was 46.9%, including 35.5% for Bartonella henselae, 45% for Bartonella clarridgeiae and 32.2% for Bartonella vinsonii subsp. berkhoffii. Three (9.7%) dogs were polymerase chain reaction (PCR) positive for the Bartonella gltA gene. Partial sequencing of that gene revealed that these three dogs were infected with B. henselae. In total, 86 fleas were collected from 26 dogs (range 1–9 fleas per dog), including 52 Ctenocephalides felis and 34 Ctenocephalides canis. Of 40 pools of fleas (20 pools of C. canis and 20 pools of C. felis), five (12.5%) were PCR positive for the Bartonella sp. gltA gene, including three C. canis pools (five fleas) and two C. felis pools (three fleas). All sequences showed 99.25% to 100% homology with B. henselae Houston I.
Association of vitamin D in patients with periodontitis: A cross-sectional study.

BACKGROUND AND OBJECTIVE Vitamin D has been considered to possess anti-inflammatory and antimicrobial activity, which may be a link for the known interaction of periodontitis (CP) and coronary heart disease (CHD). This study investigated the association between serum vitamin D levels and periodontitis in patients with CP and with CHD. Furthermore, the objective was to determine whether periodontitis and CHD had an impact on serum vitamin D levels. MATERIAL AND METHODS Using a cross-sectional design, a total of 46 patients with CP, 45 patients with CHD, 45 patients with both CP and CHD, and 43 healthy patients were enrolled in the present study. RESULTS Patients in the CP (17.4 ± 5.2 ng/mL) and in the CP + CHD (16.5 ± 5.6 ng/mL) group presented a significantly lower mean serum level of 25(OH)vitamin D compared to patients in the CHD (24.6 ± 3.7 ng/mL) and healthy control groups (29.9 ± 5.4 ng/mL) (P < .001). 25(OH)vitamin D levels were positively correlated with the number of teeth and negatively with C-reactive protein (CRP) and all periodontal parameters (P < .001). In all patients, there was a proportional increase of 25(OH)vitamin D levels with a progressive increase in number of teeth (P-trend <.001) while there were a proportional decrease in 25(OH)vitamin D levels with a progressive increase in clinical attachment level (CAL, P-trend = .001), probing depth (PD, P-trend = .006), and bleeding sites (BOP, P-trend <.001) levels. CONCLUSION Patients with CP and CP + CHD presented significantly lower serum levels of vitamin D compared to CHD and healthy controls. Moreover, the presence of CP negatively influenced serum vitamin D levels.
Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review

Abstract Purpose To provide an overview of the experiences and needs of patients adjusting to life after receiving a diagnosis of secondary progressive multiple sclerosis (SPMS). Method We conducted a meta-ethnographic synthesis of qualitative studies on the experiences of transition to SPMS, based on a systematic literature search of CINAHL, PsycINFO, Embase, MEDLINE, and Web of Science. Identified studies were quality-appraised using a critical appraisal checklist, and individual findings synthesised inductively. Results The synthesis included 12 articles with 144 people with SPMS. Adjusting to SPMS transition encompassed a variety of reactions and coping strategies. Successful adjustment was associated with accepting and adapting coping strategies, and availability of social support and relationships. Clinical services increased uncertainty around adjustment where patients felt clinicians were not transparent with them about their changing diagnosis. Conclusions People adjust to SPMS in different ways, with the success of adjustment influenced by a patient’s primary coping mechanism. Coping mechanisms are determined by pre-existing individual differences, alongside engagement with, and quality of, social support networks and activities. Services should ensure that people are provided with informational support about their illness progression, and emotional support concerning coping strategies, social networks, and physical activity, as these are key determinants of successful adjustment. IMPLICATIONS FOR REHABILITATION Adjusting to secondary progressive multiple sclerosis is a difficult and stressful time for patients. Coping strategies patients use, their support network and their activity levels are key determinants of successful adjustment. Clinicians should be open with patients about their assessment of their changing diagnosis, rather than trying to avoid upsetting the patient by withholding information. Clinical services should be proactive in supporting patients during adjustment with learning positive coping strategies, and maintaining or increasing social relationships and activity levels.
Decreased Emergency Department Overcrowding by Discharge Lounge: A Computer Simulation Study

Background: In the past decade, factors such as population growth, increased environmental incidents, and substance abuse have caused patient-overcrowding in emergency departments (EDs). Our main objective was to assess the effects of a discharge lounge on decreasing the patient waiting time and ED overcrowding by computer simulation. Methods: In this cross-sectional retrospective study, the statistical population consisted of 39264 persons referred to the ED of Al-Zahra Hospital. The sample size was calculated as 1275 through systematic random sampling at 99% confidence. To increase research accuracy, the number of patients was increased to 2515. Data were collected by standardized checklists and hospital information systems. Results: Mean waiting time for level 2 patients who left the ED against medical advice after completing the treatment was declined from 56 min to 44 min and before completing the treatment process from 80 min to 50 min. Average waiting time for level 3 patients for personal satisfaction after completing the treatment process decreased from 15 min to 13 min and before the completion of the treatment process from 67 min to 41 min; the number of discharged patients awaiting discharge was decreased at level 2 from 3 to 2 and at level 3 from 2 to 1. The number of patients waiting for admission at triage stations reduced from 44 to 39%, and the average number of patients discharged from emergency room was increased from 7 to 12. Conclusions: ED overcrowding is the hallmark of a mismatch between the availability of health care resources and patient demand for emergency care. Among major factors contributing to these situations are hindrances in patient flow and occupation of ED beds by nonurgent patients. The establishment of a discharge unit in the ED could be a practical solution to ED overcrowding.
Does bimodal hearing increase self-assessed abilities and hearing outcomes when compared to unilateral cochlear implantation?

Abstract Objective: The primary objective of this study was to compare the applicability and benefit of providing unilateral cochlear implant (CI) users with a contralateral hearing aid (HA). Design: This retrospective (case-control) study was conducted in a hospital-based CI centre. Participants self-assessed their hearing via two questionnaires (SSQ12 and HISQUI19). Objective postoperative speech perception was assessed via aided thresholds and speech perception tests (monosyllabic words, disyllabic words, and sentences) in quiet and noise. Study sample: A CI-only group (n = 113, mean age 55.1 ± 14.2 years) and a bimodal group (n = 50, mean age 56.7 ± 15.2) participated in the study. Results: No significant difference in SSQ12 or HISQUI19 scores was observed between groups. The bimodal group had a significantly better aided hearing level (p = 0.020) and speech discrimination score (p = 0.019). Conclusions: Bimodal (CI + HA) users have significantly better speech understanding than unilateral CI-only users, although this benefit may not be reflected in self-assessed outcomes. Counselling about bimodal hearing must cover expectations about potential benefits.
Antibiotic sensitivity trends of pseudomonas endophthalmitis in a tertiary eye care center in South India: A 12-year retrospective study

Purpose: To assess trends in antibiotic sensitivity of pseudomonas and compare multidrug resistance (MDR) between Pseudomonas endophthalmitis cases presenting in two consecutive 6-year time frames in a tertiary center in South India. Methods: This is a retrospective comparative series of all Pseudomonas endophthalmitis cases treated from June 2004 to May 2016. Microbiological culture results in all endophthalmitis patients were screened for pseudomonas. Positive cases in the initial 6 and final 6 years were compared for sensitivity to antibiotics and the proportion of MDR. MDR was defined as resistance to at least two different classes of antibiotics. Results: Pseudomonas accounted for 74 of 389 endophthalmitis cases (19%), 42 in initial 6 and 32 in final 6 years. Sensitivity to ciprofloxacin, ofloxacin, gatifloxacin, moxifloxacin, and ceftazidime was 85.7%, 82.9%, 76.5%, 76.9%, 88.1% up to 2010 which reduced to 75%, 59.4%, 68.8%, 56.3%, 56.3%, respectively, after 2010, being significant for ofloxacin (P = 0.0349) and ceftazidime (P = 0.0028). Susceptibility to amikacin, gentamicin, and tobramycin changed non-significantly from 83.3%, 43.9%, 47.6% to 71.9%, 61.3%, 61.3%, respectively. Twenty of 74 cases (27%) were MDR with 16.7% in first 6 years versus 40.6% in final 6 years. Postoperative MDR cases rose from 10.3% to 50% (P = 0.0048). Conclusion: This study shows rising resistance of Pseudomonas to fluoroquinolones, amikacin, and ceftazidime in endophthalmitis. MDR also showed an upward trend, particularly in postsurgical cases.
The Reciprocal Effects of Language Proficiency and Depression among Low Income Latino Youth

Extant research suggests that language plays an important role in both social processes and emotional encoding and regulation. In dual language youth, the maternal tongue has been observed as a protective factor against maladaptive outcomes (Toppelberg & Collins, 2010). Although Latino youth are at a heightened risk for depression (CDC, 2013), and a majority grow in SpanishEnglish speaking households (Pumariega et al., 2013), the impact of dual language development in their psychosocial well-being remains poorly understood. It is known that limited English language proficiency during early school years is predictive of maladaptive outcomes such as externalizing problems (Dawson & Williams, 2008). Previous studies have reported associations between Spanish and English self-reports of language proficiency and youth adjustment (Polo & Lopez, 2009). However, research has not examined objective measures of language proficiency and their relation with depression among Latino youth. Further, although some researchers have proposed that language difficulties precede depressive symptoms, the inverse has not been explored. Given the cognitive deficits often associated with depression, it is imperative to disentangle the directionality of this relation and explore the factors of depression that may hinder critical language processes. This study, which included two time points, addressed these gaps by investigating the relation between language proficiency and depression in a community sample of dual language Latino adolescents. Participants included 397 Latino students ages 10-15 years (M = 12.0; 51.9% female), the majority of whom (82.4%) were from