Miracle-dz/UniFAR-FTUs huggingface dataset:
Guanxin V attenuates myocardial ischaemia reperfusion injury through regulating iron homeostasis

Abstract Context Guanxin V (GX), a traditional Chinese medicine formula, is safe and effective in the treatment of coronary artery disease. However, its protective effect on myocardial ischaemia reperfusion injury (MIRI) is unclear. Objective To investigate the cardioprotective effect of GX on MIRI and explore the potential mechanism. Materials and methods Sprague-Dawley male rats were divided into Sham, MIRI and MIRI + GX groups. GX (6 g/kg) was administered to rats via intragastric administration for seven days before ischaemia reperfusion (IR) surgery. The infarct size, histopathology, serum enzyme activities, ultrastructure of the cardiac mitochondria were assessed. H9c2 cells were pre-treated with GX (0.5 mg/mL), and then exposed to hypoxia/reoxygenation (HR). The cell viability and LDH levels were measured. Network pharmacology was conducted to predict the potential mechanism. The related targets of GX were predicted using the TCMSP database, DrugBank database, etc. Finally, pharmacological experiments were used to validate the predicted results. Results In vivo, GX significantly reduced the myocardial infarct size from 56.33% to 17.18%, decreased the levels of AST (239.32 vs. 369.18 U/L), CK-MB (1324.61 vs. 2066.47 U/L) and LDH (1245.26 vs. 1969.62 U/L), and reduced mitochondrial damage. In vitro, GX significantly increased H9c2 cell viability (IC50 = 3.913 mg/mL) and inhibited the release of LDH (207.35 vs. 314.33). In addition, GX could maintain iron homeostasis and reduce oxidative stress level by regulating iron metabolism-associated proteins. Conclusions GX can attenuate MIRI via regulating iron homeostasis, indicating that GX may act as a potential candidate for the treatment of MIRI.
Dileptons Get Nearly 'Blind' to Mass-Scaling Effects In Hot and/or Dense Matter

Based on BHHRS and further sharpened by discussions with Gerry Brown that I had in October 2008, we arrive at the present assessment of the dilepton saga, namely, that dileptons become "blind" to changes in the vacuum structure of chiral symmetry (such as, e.g., BR scaling at high temperature and/or at high density and hence are {\em not} an appropriate probe for a signal for partial or complete chiral restoration, contrary to what has been widely believed. There, however, are a variety of indirect indications that the scaling notion is qualitatively, if not quantitatively, valid and should work in various low-energy nuclear phenomena, and it is fair to conclude that while there is no direct evidence for the scaling notion, there is {\em none against} it either, in a strong disagreement with what was claimed in CERN Courier November 2009. I will touch briefly on certain observables that could give a clear-cut litmus signal for the vacuum structure of chiral symmetry modified by temperature and/or density.
Modelling Regime Switching and Structural Breaks with an Infinite Dimension Markov Switching Model

This paper proposes an infinite dimension Markov switching model to accommodate regime switching and structural break dynamics or a combination of both in a Bayesian framework. Two parallel hierarchical structures, one governing the transition probabilities and another governing the parameters of the conditional data density, keep the model parsimonious and improve forecasts. This nonparametric approach allows for regime persistence and estimates the number of states automatically. A global identification algorithm for structural changes versus regime switching is presented. Applications to U.S. real interest rates and inflation compare the new model to existing parametric alternatives. Besides identifying episodes of regime switching and structural breaks, the hierarchical distribution governing the parameters of the conditional data density provides significant gains to forecasting precision.
New insights into disordered proteins and regions according to the FOD-M model

A collection of intrinsically disordered proteins (IDPs) having regions with the status of intrinsically disordered (IDR) according to the Disprot database was analyzed from the point of view of the structure of hydrophobic core in the structural unit (chain / domain). The analysis includes all the Homo Sapiens as well as Mus Musculus proteins present in the DisProt database for which the structure is available. In the analysis, the fuzzy oil drop modified model (FOD-M) was used, taking into account the external force field, modified by the presence of other factors apart from polar water, influencing protein structuring. The paper presents an alternative to secondary-structure-based classification of intrinsically disordered regions (IDR). The basis of our classification is the ordering of hydrophobic core as calculated by the FOD-M model resulting in FOD-ordered or FOD-unordered IDRs.
The Galactic Centre star S2 as a dynamical probe for intermediate-mass black holes

We study the short-term effects of an intermediate mass black hole (IBH) on the orbit of star S2 (S02), the shortest-period star known to orbit the supermassive black hole (MBH) in the centre of the Milky Way. Near-infrared imaging and spectroscopic observations allow an accurate determination of the orbit of the star. Given S2's short orbital period and large eccentricity, general relativity (GR) needs to be taken into account, and its effects are potentially measurable with current technology. We show that perturbations due to an IBH in orbit around the MBH can produce a shift in the apoapsis of S2 that is as large or even larger than the GR shift. An IBH will also induce changes in the plane of S2's orbit at a level as large as one degree per period. We apply observational orbital fitting techniques to simulations of the S-cluster in the presence of an IBH and find that an IBH more massive than about 1000 solar masses at the distance of the S-stars will be detectable at the next periapse passage of S2, which will occur in 2018.
Atypical phonological processes in naming errors of children with language impairment

ABSTRACT The current study explored the characteristics of phonological errors of preschool children with DLD (Developmental Language Disorder), distinguishing between typical versus atypical phonological processes in segmental, syllabic and word levels. The analysis included 87 responses of words with phonological errors from a naming test, produced by 13 preschool children with DLD, aged 4;4–6;3 years. These responses included 166 phonological processes, which were classified into typical and atypical processes at the levels of: segments, syllables, and prosodic words. The findings revealed that 70% of the phonological processes were atypical. Furthermore, ten children produced more atypical processes, and there were more atypical than typical processes in segmental and word levels. It is suggested that some children with DLD represent phonological processes that are similar to those that children with speech and sound disorders produce. Therefore, clinically, the results emphasise the importance of analysing the typical and atypical characteristics of phonological errors as part of language assessment.
Cultural differences in vocal expression analysis: Effects of task, language, and stimulus-related factors

Cultural context shapes the way that emotions are expressed and socially interpreted. Building on previous research looking at cultural differences in judgements of facial expressions, we examined how listeners recognize speech-embedded emotional expressions and make inferences about a speaker’s feelings in relation to their vocal display. Canadian and Chinese participants categorized vocal expressions of emotions (anger, fear, happiness, sadness) expressed at different intensity levels in three languages (English, Mandarin, Hindi). In two additional tasks, participants rated the intensity of each emotional expression and the intensity of the speaker’s feelings from the same stimuli. Each group was more accurate at recognizing emotions produced in their native language (in-group advantage). However, Canadian and Chinese participants both judged the speaker’s feelings to be equivalent or more intense than their actual display (especially for highly aroused, negative emotions), suggesting that similar inference rules were applied to vocal expressions by the two cultures in this task. Our results provide new insights on how people categorize and interpret speech-embedded vocal expressions versus facial expressions and what cultural factors are at play.
A comparative in vitro and in vivo study of porcine- and bovine-derived non-cross-linked collagen membranes.

The porcine-derived non-cross-linked collagen membrane Bio-gide® (BG) and the bovine-derived non-cross-linked collagen membrane Heal-all® (HA) were compared to better understand their in vitro biophysical characteristics and in vivo degradation patterns as a reference for clinical applications. It was showed that the porosity, specific surface area, pore volume and pore diameter of BG were larger than those of HA (64.5 ± 5.2% vs. 48.6 ± 6.1%; 18.6 ± 2.8 m2 /g vs. 2.3 ± 0.6 m2 /g; 0.114 ± 0.002 cm3 /g vs. 0.003 ± 0.001 cm3 /g; 24.4 ± 3.5 nm vs. 7.3 ± 1.7 nm, respectively); the average swelling ratio of BG was higher than that of HA (412.6 ± 41.2% vs. 270.0 ± 2.7%); the tensile strength of both dry and wet HA was higher than those of BG (18.26 ± 3.27 MPa vs. 4.02 ± 1.35 MPa; 2.24 ± 0.21 MPa vs. 0.16 ± 0.02 MPa, respectively); 73% of HA remained after 72 h in collagenase solution, whereas only 8.2% of BG remained. A subcutaneous rat implantation model revealed that, at 3, 7, 14, 28, and 56 days postmembrane implantation, there were more total inflammatory cells, especially more M1 and M2 polarized macrophages and higher M2/M1 ratio in BG than in HA; in addition, the fibrous capsule around BG was also thicker than that around HA. Moreover, concentrations of dozens of cytokines including interleukin-2(IL-2), IL-7, IL-10 and so forth. in BG were higher than those in HA. It is suggested that BG and HA might be suitable for different clinical applications according to their different characteristics.
Far-infrared luminosity function of local star-forming galaxies in the AKARI Deep Field-South

We present a far-infrared galaxy luminosity function for the local universe. We have obtained 389 spectroscopic redshifts for galaxies observed at 90 μ mi n theAKARI Deep Field-South, using the AAOmega fibre spectrograph via optical identifications in the digitized sky survey and 4-m class optical imaging. For the luminosity function presented in this paper, we have used those galaxies which have redshifts 0 < z < 0.25, have optical magnitudes and are not part of a newly discovered cluster of galaxies (giving a total of 130 sources). Infrared and optical completeness functions were estimated using earlier Spitzer data and automated plate measurement (APM) B-band optical data, respectively, and the luminosity function has been prepared using the 1/V max method. We also separate the luminosity function between galaxies which show evidence of predominantly star-forming activity and predominantly active galactic nucleus (AGN) activity in their optical spectra. Our luminosity function is in good agreement with the previous 90-μm luminosity function from the European Large Area Infrared Space Observatory (ISO) Survey, and we also present a luminosity function with combined AKARI and ISO data. The result is in reasonable agreement with predictions based on the earlier Infrared Astronomical Satellite (IRAS) 60-μm PSCz catalogue, and with a recent backward evolution model.
Growing massive black holes through supercritical accretion of stellar-mass seeds

The rapid assembly of the massive black holes that power the luminous quasars observed at z 6 7 remains a puzzle. Various direct collapse models have been pro- posed to head-start black hole growth from initial seeds with masses 10 5 M , which can then reach a billion solar mass while accreting at the Eddington limit. Here we propose an alternative scenario based on radiatively inecient super-critical accretion of stellar-mass holes embedded in the gaseous circum{nuclear discs (CNDs) expected to exist in the cores of high redshift galaxies. Our sub-pc resolution hydrodynamical simulations show that stellar-mass holes orbiting within the central 100 pc of the CND bind to very high density gas clumps that arise from the fragmentation of the sur- rounding gas. Owing to the large reservoir of dense cold gas available, a stellar-mass black hole allowed to grow at super-Eddington rates according to the \slim disc" solu- tion can increase its mass by 3 orders of magnitudes within a few million years. These ndings are supported by simulations run with two dierent
A Scoping Review of Health Care Faculty Mentorship Programs in Academia: Implications for Program Design, Implementation, and Outcome Evaluation

Supplemental Digital Content is Available in the Text. Introduction: Formal mentoring programs have direct benefits for academic health care institutions, but it is unclear whether program designs use recommended components and whether outcomes are being captured and evaluated appropriately. The goal of this scoping review is to address these questions. Methods: We completed a literature review using a comprehensive search in SCOPUS and PubMed (1998–2019), a direct solicitation for unpublished programs, and hand-searched key references, while targeting mentor programs in the United States, Puerto Rico, and Canada. After three rounds of screening, team members independently reviewed and extracted assigned articles for 40 design data items into a comprehensive database. Results: Fifty-eight distinct mentoring programs were represented in the data set. The team members clarified specific mentor roles to assist the analysis. The analysis identified mentoring program characteristics that were properly implemented, including identifying program goals, specifying the target learners, and performing a needs assessment. The analysis also identified areas for improvement, including consistent use of models/frameworks for program design, implementation of mentor preparation, consistent reporting of objective outcomes and career satisfaction outcomes, engagement of program evaluation methods, increasing frequency of reports as programs as they mature, addressing the needs of specific faculty groups (eg, women and minority faculty), and providing analyses of program cost-effectiveness in relation to resource allocation (return on investment). Conclusion: The review found that several mentor program design, implementation, outcome, and evaluation components are poorly aligned with recommendations, and content for URM and women faculty members is underrepresented. The review should provide academic leadership information to improve these discrepancies.
THE EFFECTS OF X-RAY FEEDBACK FROM ACTIVE GALACTIC NUCLEI ON HOST GALAXY EVOLUTION

Hydrodynamic simulations of galaxies with active galactic nuclei (AGNs) have typically employed feedback that is purely local, i.e., an injection of energy to the immediate neighborhood of the black hole (BH). We perform GADGET-2 simulations of massive elliptical galaxies with an additional feedback component: an observationally calibrated X-ray radiation field which emanates from the BH and heats gas out to large radii from the galaxy center. We find that including the heating and radiation pressure associated with this X-ray flux in our simulations enhances the effects which are commonly reported from AGN feedback. This new feedback model is twice as effective as traditional feedback at suppressing star formation, produces three times less star formation in the last 6 Gyr, and modestly lowers the final BH mass (30%). It is also significantly more effective than an X-ray background in reducing the number of satellite galaxies.
The COVID-19 pandemic effect on the prehospital Madrid stroke code metrics and diagnostic accuracy

Background Only very few studies have investigated the effect of the COVID-19 pandemic on the pre-hospital stroke code protocol. During the first wave, Spain was one of the most affected countries by the SARS-CoV-2 coronavirus disease pandemic. This health catastrophe overshadowed other pathologies, such as acute stroke, the leading cause of death among women and the leading cause of disability among adults. Any interference in the stroke code protocol can delay the administration of reperfusion treatment for acute ischemic strokes, leading to a worse patient prognosis. We aimed to compare the performance of the stroke code during the first wave of the pandemic with the same period of the previous year. Methods This was a multicentre interrupted time-series observational study of the cohort of stroke codes of SUMMA 112 and of the ten hospitals with a stroke unit in the Community of Madrid. We established two groups according to the date on which they were attended: the first during the dates with the highest daily cumulative incidence of the first wave of the COVID-19 (from February 27 to June 15, 2020), and the second, the same period of the previous year (from February 27 to June 15, 2019). To assess the performance of the stroke code, we compared each of the pre-hospital emergency service time periods, the diagnostic accuracy (proportion of stroke codes with a final diagnosis of acute stroke out of the total), the proportion of patients treated with reperfusion therapies, and the in-hospital mortality. Results SUMMA 112 activated the stroke code in 966 patients (514 in the pre-pandemic group and 452 pandemic). The call management time increased by 9% (95% CI: -0.11; 0.91; p value = 0.02), and the time on scene increased by 12% (95% CI: 2.49; 5.93; p value = <0.01). Diagnostic accuracy, and the proportion of patients treated with reperfusion therapies remained stable. In-hospital mortality decreased by 4% (p = 0.05). Conclusions During the first wave, a prolongation of the time “on the scene” of the management of the 112 calls, and of the hospital admission was observed. Prehospital diagnostic accuracy and the proportion of patients treated at the hospital level with intravenous thrombolysis or mechanical thrombectomy were not altered with respect to the previous year, showing the resilience of the stroke network and the emergency medical service.
Comparison of pediatric patients with idiopathic uveitis, and uveitis due to juvenile idiopathic arthritis and Behçet’s disease

ABSTRACT Objectives The aim of this study is to compare the demographic, clinical features, treatment results and outcomes in pediatric patients with idiopathic uveitis and uveitis due to juvenile idiopathic arthritis (JIA) and Behçet’s disease (BD). Methods 97 pediatric uveitis patients were divided into three groups according to the etiology of uveitis: Group 1 comprised idiopathic uveitis patients, Group 2 uveitis patients who had JIA, and Group 3 uveitis patients with BD. Results Symptomatic presentation and intermediate uveitis were more common in Group 1 (p < 0.005). Asymptomatic presentation and anterior uveitis in Group 2 (p < 0.005), whereas symptomatic presentation and posterior uveitis in Group 3 (p < 0.005). Erythrocyte sedimentation rate (ESR) was higher in patients with BD or JIA uveitis than those with idiopathic uveitis (p < 0.005). Biologic therapy was more commonly used in JIA group compared to other groups (p < 0.005). Patients who had a complication related with uveitis were more common in females, asymptomatic disease course, and needed use of biologic treatment than in those without any complication (p < 0.005). Conclusion Uveitis accompanying rheumatologic diseases may have asymptomatic and insidious course but have higher ESR as an important notice.
Dynamic modulations of sphingolipids and glycerophospholipids in COVID‐19

Abstract Background A heterogeneous clinical phenotype is a characteristic of coronavirus disease 2019 (COVID‐19). Therefore, investigating biomarkers associated with disease severity is important for understanding the mechanisms responsible for this heterogeneity and for developing novel agents to prevent critical conditions. This study aimed to elucidate the modulations of sphingolipids and glycerophospholipids, which have been shown to possess potent biological properties. Methods We measured the serum sphingolipid and glycerophospholipid levels in a total of 887 samples from 215 COVID‐19 subjects, plus 115 control subjects without infectious diseases and 109 subjects with infectious diseases other than COVID‐19. Results We observed the dynamic modulations of sphingolipids and glycerophospholipids in the serum of COVID‐19 subjects, depending on the time course and severity. The elevation of C16:0 ceramide and lysophosphatidylinositol and decreases in C18:1 ceramide, dihydrosphingosine, lysophosphatidylglycerol, phosphatidylglycerol and phosphatidylinositol were specific to COVID‐19. Regarding the association with maximum severity, phosphatidylinositol and phosphatidylcholine species with long unsaturated acyl chains were negatively associated, while lysophosphatidylethanolamine and phosphatidylethanolamine were positively associated with maximum severity during the early phase. Lysophosphatidylcholine and phosphatidylcholine had strong negative correlations with CRP, while phosphatidylethanolamine had strong positive ones. C16:0 ceramide, lysophosphatidylcholine, phosphatidylcholine and phosphatidylethanolamine species with long unsaturated acyl chains had negative correlations with D‐dimer, while phosphatidylethanolamine species with short acyl chains and phosphatidylinositol had positive ones. Several species of phosphatidylcholine, phosphatidylethanolamine and sphingomyelin might serve as better biomarkers for predicting severe COVID‐19 during the early phase than CRP and D‐dimer. Compared with the lipid modulations seen in mice treated with lipopolysaccharide, tissue factor, or histone, the lipid modulations observed in severe COVID‐19 were most akin to those in mice administered lipopolysaccharide. Conclusion A better understanding of the disturbances in sphingolipids and glycerophospholipids observed in this study will prompt further investigation to develop laboratory testing for predicting maximum severity and/or novel agents to suppress the aggravation of COVID‐19.