Miracle-dz/UniFAR-FTUs huggingface dataset:
Blockade of EP4 by ASP7657 Modulates Myeloid Cell Differentiation In Vivo and Enhances the Antitumor Effect of Radiotherapy

The tumor microenvironment (TME) is thought to influence the antitumor efficacy of immuno-oncology agents through various products of both tumor and stromal cells. One immune-suppressive factor is prostaglandin E2 (PGE2), a lipid mediator whose biosynthesis is regulated by ubiquitously expressed cyclooxygenase- (COX-) 1 and inducible COX-2. By activating its receptors, PGE2 induces immune suppression to modulate differentiation of myeloid cells into myeloid-derived suppressor cells (MDSCs) rather than dendritic cells (DCs). Pharmacological blockade of prostaglandin E receptor 4 (EP4) causes a decrease in MDSCs, reprogramming of macrophage polarization, and increase in tumor-infiltrated T cells, leading to enhancement of antitumor immunity in preclinical models. Here, we report the effects of the highly potent EP4 antagonist ASP7657 on the DC population in tumor and antitumor immune activation in an immunocompetent mouse tumor model. Oral administration of ASP7657 inhibited tumor growth, which was accompanied by an increase in intratumor DC and CD8+ T cell populations and a decrease in the M-MDSC population in a CT26 immunocompetent mouse model. The antitumor activity of ASP7657 was dependent on CD8+ T cells and enhanced when combined with an antiprogrammed cell death-1 (PD-1) antibody. Notably, ASP7657 also significantly enhanced the antitumor efficacy of radiotherapy in an anti-PD-1 antibody refractory model. These results indicate that the therapeutic potential of ASP7657 arises via upregulation of DCs and subsequent CD8+ T cell activation in addition to suppression of MDSCs in mouse models and that combining EP4 antagonists with radiotherapy or an anti-PD-1 antibody can improve antitumor efficacy.
Production and dissolution of biogenic silica in the ocean: Revised global estimates, comparison with regional data and relationship to biogenic sedimentation

We estimate the global rate of biogenic silica production in the ocean to be between 200 and 280 × 1012 mol Si yr−1. The upper limit is derived from information on the primary productivity of the oceans, the relative contribution of diatoms to primary production and diatom Si/C ratios. The lower limit is derived independently using a multi-compartment model of nutrient transport and biogenic particle flux, and field data on the balance between silica production and dissolution in the upper ocean. Our upper limit is 30–50% lower than several previous estimates, due to new data indicating lower values for both the relative contribution of diatoms to primary productivity and their Si/C ratios. Globally, at least 50% of the silica produced by diatoms in the euphotic zone dissolves in the upper 100 m, resulting in an estimated export of 100–140 × 1012 mol Si yr−l to the deep ocean. Our estimates correspond to a global mean rate of biogenic silica production between 0.6 and 0.8 mol Si m−2 yr−1. Incubation experiments indicate that silica production rates exceed that mean by a factor of 3–12 in coastal areas and are 2–4 times less than the global average in the oligotrophic mid-ocean gyres. The mean silica production rate in waters overlying diatomaceous sediments (approximately 10–12% of the surface area of the oceans) is 0.7–1.2 mol Si m−2 yr−1. That rate is only slightly higher than the global average, indicating that the silica produced in those regions is only 10–25% of the global total. The estimated production of biogenic silica in surface waters of the mid-ocean gyres is approximately equal to that for all major areas of opal sediment accumulation combined. Regional comparison of silica production and accumulation rates suggests a strongly bimodal character in the efficiency of opal preservation in the sea. In waters overlying diatom-rich sediments 15–25% of the silica produced in the surface layer accumulates in the seabed, while virtually none of the silica produced in other areas is preserved. The global burial/production ratio of ˜ 3% is a composite of those two very different systems. The mechanisms leading to more efficient opal preservation in regions of silica accumulation are presently unknown, but they have no simple relationship to primary productivity. Regional differences in opal preservation appear to be controlled by factors such as low surface temperature, selective grazing and aggregate formation, which diminish the rate of silica dissolution in surface waters and/or accelerate its transport to the seafloor.
CoAS-Net: Context-Aware Suction Network With a Large-Scale Domain Randomized Synthetic Dataset

Robotic grasping is one of the essential skills in robotics. From industrial to housework, robots are required to handle objects, enabling them to interact with their surroundings. Among the various tasks in robotic grasping, bin-picking is considered one of the most challenging because of the cluttered bin filled with objects. Also, for the next-level automation, they need to handle unseen objects and discriminate target objects and outliers. This letter proposes a novel dataset generation pipeline for suction-grasping in bin-picking tasks. This pipeline consists of a series of methods that progressively transit from a single object evaluation to an entire scene evaluation and lower the dimension of the labels to the image space. We trained a suction prediction FCN (Fully Convolution Network) with our dataset generated from the pipeline and conducted bin-picking experiments. Our large-scale collision-free annotation enables the network to understand the context of a bin-picking task, where collisions between the gripper and the bin or object are a concern, and distinguishing the background is crucial. The results show that our solution excels the existing methods, and the network demonstrates its context-aware grasp on objects with loosely defined RoI (Region of Interest).
Enhancing Fault Ride-Through and Voltage Support Capability for MMC-HVDC Integrated Offshore Wind Farms Based on Multi-Mode Matching

To cope with onshore AC faults in modular multilevel converter based high voltage direct current integrated offshore wind farms (OWF-MMC-HVDC), this paper proposes a multi-mode matching control (MMMC) approach. Mode I is active energy control. It is activated at high fault levels, when the reactive power output capability of the MMC is weak. Mode I uses the MMC sub-module energy to maximise the absorption of offshore surplus power to mitigate DC overvoltage problems. Mode II is dynamic reactive current optimization (DRO) control. It is activated at medium fault levels. It dynamically optimises the MMC active and reactive current command values within the permitted current margins. This simultaneously enables voltage support to the onshore grid and maximises offshore active power output, reducing offshore surplus power. Mode III is energy coordinated synchronous (ECS) control. It is activated under more mild faults. It allows simultaneous adjustment of the energy absorption rate of the wind farm-side MMC (WFMMC) and the grid-side MMC (GSMMC). This allows the energy margin of the MMCs to be utilised more fully to improve support to the onshore grid while maintaining fault ride-through capability. Finally the correctness and validity of the proposed method was verified by the PSCAD/EMTDC.
Influencing factors and knowledge related to AIDS among high-risk male population in Chongqing

This study aims to investigate the influencing factors and Acquired Immune Deficiency Syndrome (AIDS) related knowledge among high-risk male population in Chongqing. A total of 388 men who had sex with their fellow men (MSM) and volunteered for counseling or human immunodeficiency virus (HIV) testing in Chongqing were divided into two groups identified as: aware group (n = 299) and unaware group (n = 89). According to the study subjects, the MSM sentinel surveillance questionnaire of the Chinese Center for Disease Control and Prevention was utilized to investigate their AIDS awareness demographic and behavioral characteristics. Univariate analysis was also applied to analyze the influencing factors of their AIDS knowledge. Binary multivariate logistic analysis was further used to screen the independent risk factors of AIDS inadequate knowledge, leading to the use of regression analysis model. Furthermore, hosmer and lemeshow were employed to test the goodness and fitness of the regression analysis model. Finally, SPSS was used to draw receiver operating characteristic (ROC) curves to evaluate the predictive value of the regression analysis model. Among 388 respondents, 299 participants were aware while 89 participants were unaware of AIDS-related knowledge with an overall awareness rate of 77.06%; univariate and multivariate logistic regression analysis showed that education (high school and below) and household registration (other places) were risk factors for AIDS-related knowledge in high-risk male groups in Chongqing. In addition, a probability model predicted high incidence of AIDS in high-risk male groups in Chongqing because of inadequate AIDS knowledge: P = 1/[1 + exp (1.429 − 1.169X2 − 0.969X3)]. The overall level of awareness of AIDS-related knowledge among high-risk male groups in Chongqing was not high because of low education levels (high school or below) and foreign household registration.
The determinants of higher education institutions’ (HEIs) sustainability reporting

Abstract This study analyses the relationship between sustainability performance, convention signatures, sustainability offices, sustainability research, teaching programs, student clubs, financial statements, and the extent of sustainability reporting in higher education institutions (HEIs). The sample of this study was 153 unit of analysis of 57 HEIs which are registered in the Global Reporting Initiative database during the period 2010–2020. Descriptive, content, and multivariate regression analysis were used to analyze the data and test the hypotheses. The level of sustainability performance, convention signatures, sustainability offices, sustainability research, teaching programs, student clubs, financial statements have a significant effect on the extent of sustainability reporting. Moreover, the random effect model is the best approach for estimating the model. The study contributes to a better understanding of the determinants of HEIs sustainability reporting. Several previous studies only used one theoretical lens. The originality of this research is using a metatheoretical approach, namely stakeholder and legitimacy theory. The theoretical implication of these findings is that the combination of legitimacy and stakeholder theory is able to explain more broadly the model of HEIs sustainability reporting. Policymakers such as the government and other key stakeholders can use these findings as the basis for assessing an educational institution’s sustainability performance.
On the Metamorphic Lower Silurian Rocks of Carrick, Ayrshire

I. Introduction The metamorphic region which forms the subject of this communication was traversed by Sir Roderick Murchison, accompanied by Professor J. Nicol, in 1850; and the former geologist subsequently published the results of that journey, in a memoir upon the geology of the South-western Highlands of Scotland; but as the end Sir Roderick had in view was mainly to ascertain the structure of the strata and determine their position, his allusions to the metamorphic rocks are necessarily brief. In the spring of 1865 the Geological Survey was extended into the southern regions of Ayrshire, and thus afforded my colleagues (Dr. Young and Mr. A. Geikie) and myself ample facilities for a more minute examination of the beds in question. We recognized the metamorphic character of certain diorites, serpentines, and crystalline felspathic rocks, independently of each other; and in the area that fell to me to survey I was enabled to trace passages between the various altered rocks, which seem to throw light upon the obscure process of metamorphic action. The interest which is attached to the altered strata of this district chiefly consists in the fact that they exhibit certain arrested stages of metamorphic action, so that we can in many instances begin with unaltered beds and trace the gradual changes which they undergo during their passage into crystalline and pseudo-igneous rocks. The large masses of amygdaloid indicated upon the sketch map which accompanies Sir Roderick's memoir, notwithstanding their exceedingly igneous aspect, are nevertheless, as will be shown, not of
Neighbourhoods in shaping migrant integration: A study of peri-urban Beijing

The question of how (im)migrants integrate into their host societies has long been a focus of scholarly research. This article adds to this body of knowledge by examining how different types of neighbourhoods shape the integration experience of migrant residents and their daily practice in peri-urban Beijing. The study was conducted by non-participant observation and semi-structured interviews in four peri-urban Beijing neighbourhoods. The findings suggest that migrant integration has a spatial dimension, with integration differences being enhanced and fixed through residential differentiation. Specifically, a migrant’s position in the urban economy predetermines their integration path and neighbourhood preference, with the neighbourhood further impacting their social integration through embedded lifestyles and ideologies. Neighbourhoods serve as essential places of shared experience in which distinct migrant social groups are formed. Theoretically, the study contributes to the debate between ethnic enclaves and mixed neighbourhoods by arguing that mixed neighbourhoods foster stronger sentiments toward host cities among migrant residents. The failure of integration is not necessarily a result of a neighbourhood’s homogenous tenure and population but rather because residents are not involved in the formal urban economy. Unlike ethnoburbs in America, urban villages in peri-urban Beijing cannot generate upward social mobility because of the informality. Low-skilled migrant entrepreneurs struggle to develop their informal businesses facing unpredictable demolishment of urban villages.
Mite biodiversity on vegetables in plastic-houses and the efficacy of an essential oil mixture on Tetranychus urticae and Phytoseiulus persimilis

ABSTRACT We surveyed the mite fauna on three vegetable crops (cucumber, eggplant, and pepper) in plastic-houses throughout the autumn of 2020 by taking weekly leaf samples. These samples revealed several plant-feeding and predatory mites belonging to 13 species in ten genera and five families, as well as some insect pests. Tetranychus urticae Koch (Tetranychidae) was a significant pest in all three crops and Integrated Pest Management (IPM) control was used for its control. A bioassay was performed to evaluate the effect of a mixture of essential oils (clove, lavender, eucalyptus, and sweet orange) on T. urticae and its associated predator, Phytoseiulus persimilis Athias-Henriot (Phytoseiidae). The lethal concentration of this essential oil mixture determined by laboratory bioassay, was used on eggplant and cucumber crops in plastic-houses. The active ingredients of the tested oil mixture were determined using GC-MS analysis of the mixed essential oil. The total constituents of the mixed essential oil were identified as 43 compounds, primarily d-limonene, but also monoterpenes, sesquiterpens, diterpens, sestetraterpens, triterpens, and tetraterpens.
Treatment for a primary multidrug-resistant B-cell acute lymphoblastic leukemia patient carrying a SSBP2-CSF1R fusion gene: a case report

SSBP2-CSF1R is an important biomarker for clinical diagnosis and prognosis of Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). This case report presents a pediatric Ph-like ALL patient carrying the SSBP2-CSF1R fusion gene. The patient was resistant to most conventional chemotherapy regimens and to dasatinib, an inhibitor that has been reported to have a therapeutic effect on SSBP2-CSF1R fusion Ph-like ALL, as she remained minimal residual disease (MRD) positive (detection by flow cytometry) and SSBP2-CSF1R fusion gene (detection by RT-PCR) positive after five rounds of such regimens. We thus conducted a large-scale in vitro screening to assess the sensitivity of the patient’s leukemic cells to anti-cancer drugs. Based on the susceptibility results, we chose to combine cytarabine, homoharringtonine, dexamethasone, fludarabine, vindesine, and epirubicin for treatment. Clinical results showed that after a course of treatment, both MRD and SSBP2-CSF1R fusion gene turned negative, and there was no recurrence during an 18-month follow-up. In conclusion, our study suggests that the SSBP2-CSF1R fusion gene may be an important biomarker of primary drug resistance in Ph-like ALL, and indicate that the combination of cytarabine, homoharringtonine, dexamethasone, fludarabine, vindesine, and epirubicin can achieve optimal therapeutic results in this category of patients.
He,Ar Isotope Characteristics and Rb-Sr Dating of the Xintianling Skarn Scheelite Deposit in Southern Hunan, China

The Xintinling scheelite deposit, located in the northern contact zone of the Qitinling pluton, is a large-size skarn deposit. So far only very insufficient work has been done in this deposit. In this paper, He and Ar isotopes of fluid inclusions in pyrite was studied, and the ratio of 3He/4He obtained is 4.08 Ra (Ra=1.4×10-6, modern atmospheric ratio), which is significantly higher than that of crustal fluids (0.01～0.05 Ra), suggesting that ore-forming fluids contain not only crustal-derived He but also abundant mantle-derived He. The Rb-Sr isochron dating of quartz from scheelite-quartz veins is (157.4±3.2)Ma(2σ), which indicates the ore-forming epoch of the Xintinling deposit belongs to early Yanshanian (Middle Cretaceous). This age is consistent with that of the Shizhuyuan superlarge W-Sn polymetallic deposit and the Furong large Sn polymetallic deposit, implying that Middle Cretaceous is a major metallogenic epoch of W-Sn polymetallic deposits in southern Hunan.
Erythrocyte Indices Variations In Under Five Children As A Result Of High Plasmodium Falciparum Parasitaemia

Nigeria accounts for 31% of the 619,000 malaria-related deaths recorded worldwide, according to the World Malaria Report 2022. Malaria caused by Plasmodium falciparum causes significant changes in haematological parameters and indices. The study aimed to observe erythrocyte indices and haemoglobin concentration variations in children with Plasmodium falciparum parasitaemia, evaluate the correlation between parasite count and indices, and assess their predictive roles. We analysed 194 children (≤ 5 years old) suspected of malaria and collected 5 ml of whole blood samples for analysis. The samples were used to prepare thin and thick blood films for qualitative and quantitative assays. A CBC was carried out to estimate HGB concentration and erythrocyte indices. The case and control group had a mean difference statistically significant at (P<0.001). MCV [case group (72.26±4.83), control group (85.00±4.48)]; MCH [case group (23.82±2.51), control group (28.85±2.02)] and HGB [case group (100.78±14.84), control group (135.65±9.95). Pearson correlation showed weak negative statistical significance at (P<0.05) for MCV, MCH, MCHC and HGB in the range of (-0.38) – (-0.218). Regression analysis indicated that parasite count predicted MCV, MCH, MCHC and HGB at (P<0.05); R values at (0.283, 0.272, 0.326 and 0.308, respectively). When considering age and parasite count as predictive variables, we obtained R values of 0.285, 0.282, 0.326, and 0.328 for MCV, MCH, MCHC, and HGB, respectively. Research results show a significant relationship between Plasmodium falciparum parasitaemia and variations in erythrocyte indices with haemoglobin concentration in children at significant levels.
Prosocial Behaviours and Resilience in School Coexistence: Implications of Creative Self-Efficacy and Stress in Adolescents

Adolescence brings with it a number of problems such as school violence. To reduce stress and increase the well-being of students, it is necessary to enhance certain skills such as prosocial behaviours, resilience, and creative self-efficacy. This cross-sectional study investigated the impact of prosocial behaviours and creative self-efficacy on school violence, stress, and resilience in adolescent students. A total of 743 students aged 14–19 years participated. The results revealed positive correlations between the dimensions of prosocial behaviours, creative self-efficacy, and resilience, and negative correlations with perceived stress. Differences were also observed in the relationship between prosocial behaviours, school violence, and stress. Mediation models indicated that creative self-efficacy acted as a mediator between prosocial behaviours and resilience. In addition, stress was found to moderate the relationship between prosocial behaviours and resilience. This study provides evidence on how prosocial behaviours, resilience, and creative self-efficacy act as a positive element in adolescence.
Life-Cycle-Dependent Toxicities of Mono- and Bifunctional Alkylating Agents in the 3R-Compliant Model Organism C. elegans

Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In this study, we explored the use of C. elegans to examine the toxicities of alkylating sulphur mustard analogues, specifically the monofunctional agent 2-chloroethyl-ethyl sulphide (CEES) and the bifunctional, crosslinking agent mechlorethamine (HN2). We exposed wild-type worms at different life cycle stages (from larvae L1 to adulthood day 10) to CEES or HN2 and scored their viability 24 h later. The susceptibility of C. elegans to CEES and HN2 paralleled that of human cells, with HN2 exhibiting higher toxicity than CEES, reflected in LC50 values in the high µM to low mM range. Importantly, the effects were dependent on the worms’ developmental stage as well as organismic age: the highest susceptibility was observed in L1, whereas the lowest was observed in L4 worms. In adult worms, susceptibility to alkylating agents increased with advanced age, especially to HN2. To examine reproductive effects, L4 worms were exposed to CEES and HN2, and both the offspring and the percentage of unhatched eggs were assessed. Moreover, germline apoptosis was assessed by using ced-1p::GFP (MD701) worms. In contrast to concentrations that elicited low toxicities to L4 worms, CEES and HN2 were highly toxic to germline cells, manifesting as increased germline apoptosis as well as reduced offspring number and percentage of eggs hatched. Again, HN2 exhibited stronger effects than CEES. Compound specificity was also evident in toxicities to dopaminergic neurons–HN2 exposure affected expression of dopamine transporter DAT-1 (strain BY200) at lower concentrations than CEES, suggesting a higher neurotoxic effect. Mechanistically, nicotinamide adenine dinucleotide (NAD+) has been linked to mustard agent toxicities. Therefore, the NAD+-dependent system was investigated in the response to CEES and HN2 treatment. Overall NAD+ levels in worm extracts were revealed to be largely resistant to mustard exposure except for high concentrations, which lowered the NAD+ levels in L4 worms 24 h post-treatment. Interestingly, however, mutant worms lacking components of NAD+-dependent pathways involved in genome maintenance, namely pme-2, parg-2, and sirt-2.1 showed a higher and compound-specific susceptibility, indicating an active role of NAD+ in genotoxic stress response. In conclusion, the present results demonstrate that C. elegans represents an attractive model to study the toxicology of alkylating agents, which supports its use in mechanistic as well as intervention studies with major strength in the possibility to analyze toxicities at different life cycle stages.