Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety of Vitamin K in mechanical heart valve patients with supratherapeutic INR: A systematic review and meta-analysis

Background: Patients who had mechanical heart valves and an international normalized ratio (INR) of >5.0 should be managed by temporary cessation of vitamin K antagonist. This study aimed to investigate the safety of low-dose vitamin K1 in patients with mechanical heart valves who have supratherapeutic INR. Methods: CINAHL, Cochran Library, Clinical trial.gov, OpenGrey, PubMed, ScienceDirect, and Scopus were systematically searched from the inception up to October 2021 without language restriction. Studies comparing the safety of low-dose vitamin K1 treatment in patients with placebo or other anticoagulant reversal agents were included. We used a random-effect model for the meta-analysis. Publication bias was determined by a funnel plot with subsequent Begg’s test and Egger’s test. Results: From 7529 retrieved studies, 3 randomized control trials were included in the meta-analysis. Pooled data demonstrated that low-dose vitamin K was not associated with thromboembolism rate (risk ratio [RR] = 0.94; 95% CI: 0.19–4.55) major bleeding rate (RR = 0.58; 95% CI: 0.07–4.82), and minor bleeding rate (RR = 0.60; 95% CI: 0.07–5.09). Subgroup and sensitivity analysis demonstrated the nonsignificant effect of low-dose vitamin K on the risk of thromboembolism. Publication bias was not apparent, according to Begg’s test and Egger’s test (P = .090 and 0.134, respectively). Conclusion: The current evidence does not support the role of low-dose vitamin K as a trigger of thromboembolism in supratherapeutic INR patients with mechanical heart valves. Nevertheless, more well-designed studies with larger sample sizes are required to justify this research question.
The value of surgeon’s perception during transurethral resection of bladder tumors: can we trust in our eyes and experience to predict grade and staging?

Background: Transurethral resection of newly diagnosed bladder tumors (TURBT) is a hallmark ¡n the treatment of bladder cancer. We evaluated the surgeon capacity to predict bladder tumor stage (T), grade, and presence of muscular layer based upon cystoscopic characteristics during primary TURBT. Methods: Prospective study enrolling 100 consecutive patients undergoing primary TURBT for newly diagnosed bladder cancers. Cystoscop¡c tumor characteristics at the time of TURBT was evaluated by an urology senior and a resident regarding histological grade, invasion (T stage), and presence of muscular layer in the specimen. We analyzed the surgeon’s accuracy in predicting these parameters using the final histology as gold standard. In addition, the predictive capacity between seniors and residents was compared. Results: The resident’s arm correctly predicted tumor invasiveness in 76% of cases, while seniors correctly predicted 87% of cases. Regarding tumor grade, high grade cancer was reported in 78% of the specimens and 75% and 77% of them were correctly predicted by residents and seniors, respectively. Finally, 80% of the TURBT specimens had muscle representativeness. In nearly 75% of the cases, both resident and senior correctly predicted the TURBT resection depth (presence of detrusor muscle in the specimen). The positive predictive value for this parameter was 79% for the resident, and 81% for the senior, and the negative predictive value was 25% and 40%, respectively. Conclusion: The surgeon’s naked eye analysis showed a good, but limited predictive ability to detect non-muscle invasive and high-grade bladder tumors in TURBT specimens. Positive predictive value for muscle representativeness is around 80%, which reinforces the need of carrying out a careful and extensive TURBT, irrespective of the surgeon experience.
Prognostic significance of systemic immune-inflammation index in patients with bladder cancer: A systematic review and meta-analysis

Background: Systemic Immune-inflammation Index (SII) has been shown to correlate with the prognosis of numerous malignancies, but researchers have not yet reached an agreed conclusion on bladder cancer. To fill the blank, we conducted a meta-analysis to assess the prognostic role of SII in the prognosis of bladder cancer. Methods: After analyzing relevant literature published in PubMed, China National Knowledge Infrastructure, EMBASE, Cochrane Library, and Web Science up to April 30, 2022, we collected 83 articles to assess the significance of SII levels in assessing the prognosis of bladder cancer patients, and finally, 11 articles were included in the study. The correlation between pre-treatment Systemic Immunoinflammatory Index levels and survival in bladder cancer patients was assessed using risk ratio (HR) and 95% confidence interval (CI). Results: Our meta-analysis comprised 11 papers altogether, and the findings revealed that higher levels of pretreatment SII were significantly associated with poorer overall survival/cancer-specific survival/progression-free survival/recurrence-free survival in bladder cancer patients (pooled HR = 1.80; 95% CI, 1.28–2.51; pooled HR = 1.68; 95% CI, 1.14–2.47; pooled HR = 1.74; 95% CI, 1.25–2.42; pooled HR = 1.73; 95% CI, 1.26–2.39). The above result was also confirmed in the subgroup analysis. Conclusions: Higher SII levels were significantly connected with overall survival/cancer-specific survival/progression-free survival/recurrence-free survival rates in bladder cancer patients, suggesting that SII is an important predictor of prognosis in bladder cancer patients.
Randomized, direct comparison study of Saccharomyces boulardii CNCM I-745 versus multi-strained Bacillus clausii probiotics for the treatment of pediatric acute gastroenteritis

Background: The choice of an appropriate probiotic for pediatric acute gastroenteritis (PAGE) can be confusing. Our aim was to compare the efficacy and safety of 2 probiotics (Saccharomyces boulardii CNCM I-745 vs a 4-strain mixture of Bacillus clausii O/C, SIN, N/R, T) for the treatment of PAGE. Methods: A 2-arm parallel, randomized trial recruited children (6 months to 5 years old) with mild-moderate acute diarrhea, from 8 centers in Argentina. A total of 317 children were enrolled and blindly randomized to 5 days of either S boulardii CNCM I-745 (n = 159) or a 4-strain mixture of B clausii (n = 158), then followed for 7 days post-probiotic treatment. A stool sample was collected at inclusion for pathogen identification. The primary outcome was duration of diarrhea defined as the time from enrollment to the last loose stool followed by the first 24-hour period with stool consistency improvement. Secondary outcomes included frequency of loose stools/day, severity of diarrhea, number reporting no diarrhea at Day 6, time-to-first formed stool, recurrence of diarrhea by study end (Day 12) and safety outcomes. Results: Three hundred twelve (98%) children completed the study. S boulardii CNCM I-745 showed a significant reduction (P = .04) in the mean duration of diarrhea (64.6 hours, 95% confidence interval [CI] 56.5–72.8) compared to those given B clausii (78.0 hours, 95% CI 69.9–86.1). Both probiotics showed improvement in secondary outcomes and were well-tolerated. Conclusion: In this study, S boulardii CNCM I-745 demonstrated better efficacy than B clausii mix for reducing the duration of pediatric acute diarrhea.
2nd Global Summit and Expo on Lasers, Optics and Photonics

Since 2014 novel consumer applications like Netflix, Block Chain, LIDAR. not known at that time have led to a huge increase of internet traffic of 60%/year, much more than then originally predicted by companies like Cisco. This increased use of the internet is increasing its electrical power consumption due to increased data traffic mostly inside data centers. New data centers have crossed the 500 MW level. 5G with its big jump in data speed will be another enabler for new services, like LIDAR and more we cannot think about yet, and will increase the energy consumption to an extent not further tolerable. More research has to be done on the energy-efficiency of data traffic on all hierarchy levels. Inside data centers advanced design of active optical cables, their electronic driver and receiver circuits and the active photonic devices are suddenly in the focus, but now with the goal to minimize their combined power consumption. Vertical-cavity surface-emitting lasers (VCSELs) for 200+ Gbit/s single fiber data transmission across OM5 multimode fiber with a record heat to bit rate ratio (HBR) of only 240 fJ/bit x wavelength @ 50Gbit/s developed in our labs are presented. Photon lifetime management is a new key to adopt the overall energy consumption to the bit rate of the data traffic (e.g. 25 Gb/s, 50 Gb/s,.). A completely novel design approach for VCSELs will be presented based on etching multiple holes, oxidizing one or several apertures from these holes and refilling them with metal, in order to increase heat conduction and cut-off frequency and reduce parasitic effects. Thermal roll-over is expected to appear at much larger currents compared to the present standard designs, allowing larger single mode output power and possibly dense wavelength multiplexing across distances of several hundred m to 1 km in data centers. Finally work on high speed novel drivers based on advanced CMOS design is reported, leading to dramatically reduced energy consumption of VCSEL modules below 500 fJ/bit.
Assessment of key factors involved in the swimming start technique: a pilot study with secondary education students

The physical education curriculum at secondary level is broad and flexible, facilitating the inclusion of sports content such as swimming, especially in schools having their own sports club. In addition to the teaching of technical elements, an evaluation may be included to provide teachers with reliable information on the achievement of objectives. The effective execution of the starting technique can be fundamental to the event performance; therefore, the aim of this study was to know and understand the influence of lower body extensor strength, ischiosural extensibility and starting angle on the swim start in young student-swimmers. Nineteen participants (15.95 ± 2.7 years) performed three starts using the Track Start technique (TS). Forward leg knee angle, lower body strength measured through various jump tests, and ischiosural extensibility using the straight leg raise test (SLR) were assessed in this study. The results showed that there was no correlation between the front leg knee angle and starting performance (T15), as well as between the swimming start variables and ischiosural extensibility. All three jumping tests showed high correlations with T15 (p = .000). The results suggest that the degree of swimmers’ ischiosural extensibility is not a limiting factor in the swim start outcome. The SJ and especially the SLJ tests, due to their technical similarity, are suitable for assessing lower body extensor strength in young swimmers, as well as to predict the outcome at T15. sugieren que el grado de extensibilidad isquiosural de los nadadores no es un factor limitante en el resultado de la salida. Los test SJ y especialmente el SLJ por su similitud técnica, son adecuados para valorar la fuerza extensora del tren inferior en jóvenes nadadores, así como predecir el resultado en T15.
Large remanent polarization of 100% polar-axis-oriented epitaxial tetragonal Pb(Zr0.35Ti0.65)O3 thin films

100% polar-axis (c-axis)-oriented epitaxial Pb(Zr0.35Ti0.65)O3 (PZT) thin films were grown and their large remanent polarization (Pr) was directly measured. Perfectly c-axis-oriented epitaxial PZT thin films were obtained on (100)cSrRuO3//(100)SrTiO3 substrates when the deposition temperature increased to 540 °C together with a decrease in the film thickness down to 50 nm. Polarization–electric-field hysteresis loops were well saturated and had a square shape. The Pr of a 50 nm thick film saturated at 0.9 V, and its value was over 90 μC/cm2; almost independent of the measurement frequency within the range from 20 Hz to 1 kHz. This value was in good agreement with the estimated one from the a- and c-axes mixture-oriented epitaxial PZT film having the same composition taking into account the fact that only the c-axis-oriented domain contributed to the polarization. On the other hand, the coercive field value of a perfectly c-axis-oriented film was 140 kV/cm and almost the same as that of the mixture-oriente.
Study of the protective effects of cyanocobalamin on methotrexate induced nephrotoxicity in rats [version 1; peer review: awaiting peer review]

Background: Methotrexate (MTX) is a chemotherapeutic drug, used mainly in many cancerous stages, inflammatory and auto-immune diseases, but its use has been limited by its nephrotoxicity. Cyanocobalamin is a water-soluble vitamin possessing nephroprotective properties. The aim of this study was to investigate the effect of cyanocobalamin on the nephrotoxicity of methotrexate. Methods: In the study 42 albino adult female rats were used, divided into six groups each containing seven rats (n=7). 1 st group: Control group (Negative control), 7 rats were injected intraperitoneally with 0.5ml/kg/day NS. Second group: 7 rats were injected intraperitoneally with a single dose of methotrexate (20 mg/kg) for 4 days. Third Group: 7 rats were given intraperitoneally cyanocobalamin at a dose (1.5 mg/kg/day) for two weeks, fourth, fifth, sixth group: 7 rats from each group were injected intraperitoneally with different concentrations of cyanocobalamin (0.5, 1, 1.5 mg/kg /day), respectively, for two weeks and MTX (20 mg/kg), which was injected only on day 11. On day 15, rats from all groups were euthanized, and blood samples were taken for biochemical tests, including evaluating This study demonstrates the beneficial effects of cyanocobalamin on MTX-induced nephrotoxicity. Data suggest that the protective effect of cyanocobalamin is through the amelioration of oxidative markers (MDA) in kidney homogenate; the improvement of antioxidants (GSH), compensating for the increase in urea, creatinine, and the improvement of histopathological lesions of the kidney of rats. These results will make a new technique of protection from nephrotoxicity by MTX therapy, by administration of cyanocobalamin.
The opportunity of data mining for macroeconomic data analysis: A case analysis of East Java Province

The conventional data analysis in economics is based on a model derived from economic theories. In contrast, data mining is a data-driven analysis to extract data and find a pattern describing the empirical interaction between variables. The emerging area of data mining offers an opportunity for extracting information from macroeconomic data. However, it is still a challenge for economic researchers and policymakers to embrace data mining because it is closely related to the information technology discipline. This study responds to the limited use of data mining in the economic area by analyzing macroeconomic indicators published by the Indonesian Central Bureau of Statistics. The primary purpose of this study is to offer a case for using the data mining approach for macroeconomic indicators. The specific objectives were (1) to introduce the Cross-Industry Standard Process for Data Mining (CRISP-DM) as a process framework and Knime Analytics Platform as a data mining software for macroeconomic data analysis; and (2) to characterize East Java regencies/municipalities based on their macroeconomic indicators and region profiles. This study was categorized as secondary and quantitative research. The unit of analysis was the regency/municipality. Five macroeconomic indicators: Human Development Index (HDI), Gross Regional Domestic Products (GRDP), poverty rate, Gini Ratio, and open unemployment rate, were selected as the variables. Four region profiles: area, population, population density, and the number of villages were included in the analysis. The clustering model was implemented through Knime’s workflow. The result of clustering grouped 38 regions into three. Its applicability and simplicity indicated the appropriateness of the CRISP-DM process framework for analyzing the structured official data. Furthermore, the predictive model, applied to past years’ datasets, revealed the regions that experienced improvement and shifted their membership between clusters over three years. Moreover, the inclusion of region profiles has provided a better understanding of underlying factors explaining the association between macroeconomic indicators. This study suggests that the East Java Government considers different facilitation-focused programs based on the characteristics of three clusters for better budget efficiency. This research adds to the literature on economic development, particularly by introducing data mining, the CRISP-DM method, and Knime software to analyze macroeconomic indicators of regency/municipality.
Quantum mechanics without quanta arXiv:1507.02113 [quant-ph]

In this paper, I argue that light is a continuous classical electromagnetic wave, while the observed so-called quantum nature of the interaction of light with matter is connected to the discrete (atomic) structure of matter and to the specific nature of the light-atom interaction. From this point of view, the Born rule for light is derived, and the double-slit experiment is analysed in detail. I show that the double-slit experiment can be explained without using the concept of a “photon”, solely on the basis of classical electrodynamics. I show that within this framework, the Heisenberg uncertainty principle for a “photon” has a simple physical meaning not related to the fundamental limitations in accuracy of the simultaneous measurement of position and momentum or time and energy. I argue also that we can avoid the paradoxes connected with the wave-particle duality of the electron if we consider some classical wave field “an electron wave” instead of electrons as the particles and consider the wave equations (Dirac, Klein-Gordon, Pauli and Schrödinger) as the field equations similar to Maxwell equations for the electromagnetic field. It is shown that such an electron field must have an electric charge, an intrinsic angular momentum and an intrinsic magnetic moment continuously distributed in the space. It is shown that from this perspective, the double-slit experiment for “electrons”, the Born rule, the Heisenberg uncertainty principle and the Compton effect all have a simple explanation within classical field theory. The proposed perspective allows consideration of quantum mechanics not as a theory of particles but as a classical field theory similar to Maxwell electrodynamics.
Influence of different irrigation regimes and planting times on the quality and quantity of calyx, seed oil content and water use efficiency of roselle (Hibiscus sabdariffa L.)

This study was carried out to examine the physiological traits, quality of calyx extract and seed oil content of roselle (Hibiscus sabdariffa L.) as affected by irrigation regimes and planting dates. The growth period from seed sowing to calyx harvesting was shortened as planting time was delayed. Stem diameter and plant height were decreased by drought stress or late planting, but calyx yield, total phenolic content, total anthocyanin content, vitamin C, and calyx water use efficiency increased under mild drought condition. In addition, antioxidant activity and calyx water use efficiency were significantly increased by late planting. It was suggested that an increase in calyx harvest index in delay in planting would be due to better photosynthesis activity and higher assimilate use efficiency because of the increase in sink capacity. Seed oil content decreased considerably due to drought stress and delay in planting date. These findings suggest that mild drought stress improves the quality and quantity of calyx and water use efficiency.
Nil Bohr$_0$-sets, Poincar\'e recurrence and generalized polynomials

The problem which can be viewed as the higher order version of an old question concerning Bohr sets is investigated: for any $d\in \N$ does the collection of $\{n\in \Z: S\cap (S-n)\cap. \cap (S-dn)\neq \emptyset\}$ with $S$ syndetic coincide with that of Nil$_d$ Bohr$_0$-sets? In this paper it is proved that Nil$_d$ Bohr$_0$-sets could be characterized via generalized polynomials, and applying this result one side of the problem could be answered affirmatively: for any Nil$_d$ Bohr$_0$-set $A$, there exists a syndetic set $S$ such that $A\supset \{n\in \Z: S\cap (S-n)\cap. \cap (S-dn)\neq \emptyset\}. $ Note that other side of the problem can be deduced from some result by Bergelson-Host-Kra if modulo a set with zero density. As applications it is shown that the two collections coincide dynamically, i.e. both of them can be used to characterize higher order almost automorphic points.
A case for connecting school-based health education in Aotearoa New Zealand to critical health literacy

ABSTRACT Critical health literacy (CHL) and more specifically the development of young people's CHL in school-based health education is an under-explored area in research. This is despite health literacy being viewed as a critical determinant of health in contemporary times (World Health Organization. (2016a). The mandate for health literacy. https://www.who. int/healthpromotion/conferences/9gchp/health-literacy/en/) and the ever-growing recognition of the need for people to be critical consumers and producers of knowledge in the twenty-first century. In this paper, we present findings from a qualitative study which explored the learning experiences and outcomes of senior secondary school-based health education in Aotearoa New Zealand. We conducted a deductive thematic analysis based upon a range of authors' descriptions of the components of CHL. Our findings indicate multiple ways in which health education has the potential to connect to the development of CHL, with these organized into four themes: Taking individual and collective action to promote health, interpersonal awareness and skills, knowledge of community and political structures and social determinants of health, critical thinking and appraisal of health-related information. We conclude the paper with implications for policy and practice relating to CHL in our complex times, as well as avenues for future inquiry in this under-researched area.
Moduli of curves and abelian varieties : the Dutch Intercity Seminar on Moduli

- Gerard van der Geer / Frans Oort: Moduli of Abelian Varieties: A Short Introduction and Survey. - Carel Faber/ Eduard Looijenga: Remarks on Moduli of Curves. - Robbert Dijkgraaf: Fields, Strings, Matrices and Symmetric Products. - Carel Faber: A Conjectural Description of the Tautological Ring of the Moduli Space of Curves. - Gerard van der Geer: Cycles on the Moduli Space of Abelian Varieties. - Richard Hain: Locally Symmetric Families of Curves and Jacobians. - Eduard Looijenga: Correspondences between Moduli Spaces of Curves. - Frans Oort: A Stratification of a Moduli Space of Polarized Abelian Varieties in Positive Characteristic.
The Optimum Exponent In Inverse-Distance Weighted Method Of Contour Generation – Case Of Environmental Gamma-Ray Dose Rate Distribution

The inverse-distance weighted interpolation routine is a very widely used method of contour generation. Despite this fact, hitherto there has been no firm basis that one can refer to when deciding on the optimal exponent value of the weight. We report here our success with a series of comprehensive computer simulations and verification analyses that have produced useful guidelines for the optimal choice of exponent values. The test data were simulated isotropic spatial gamma ray distributions characterised via one-dimensional power spectrum analysis. Since the analysis is independent of the true identity of the data, the results may be extended to other applications, particularly scattered sets of isotropic environmental data. Our results show that the optimum exponent value is not the prevailing favourite of 2, but varies from 3 to 7; lower values for greatly fluctuating or noisy types of data field and higher values for smooth types of data field. Radiation Earth Science Laboratory, Nagoya, Japan 2004