Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Chronological Age, Relative Age, and Maturation Status on Accumulated Training Load and Perceived Exertion in Young Sub-Elite Football Players

The aims of this study were 1) to analyze the influence of chronological age, relative age, and biological maturation on accumulated training load and perceived exertion in young sub-elite football players and 2) to understand the interaction effects amongst age grouping, maturation status, and birth quartiles on accumulated training load and perceived exertion in this target population. A 6-week period (18 training sessions and 324 observation cases) concerning 60 young male sub-elite football players grouped into relative age (Q1 to Q4), age group (U15, U17, and U19), and maturation status (Pre-peak height velocity (PHV), Mid-PHV, and Post-PHV) was established. External training load data were collected using 18 Hz global positioning system technology (GPS), heart-rate measures by a 1 Hz short-range telemetry system, and perceived exertion with total quality recovery (TQR) and rating of perceived exertion (RPE). U17 players and U15 players were 2.35 (95% CI: 1.25–4.51) and 1.60 (95% CI: 0.19–4.33) times more likely to pertain to Q1 and Q3, respectively. A negative magnitude for odds ratio was found in all four quartile comparisons within maturation status (95% CI: 6.72–0.64), except for Mid-PHV on Q2 (95% CI: 0.19–4.33). Between- and within-subject analysis reported significant differences in all variables on age group comparison measures (F = 0.439 to 26.636, p = 0.000 to 0.019, η2 = 0.003–0.037), except for dynamic stress load (DSL). Between-subject analysis on maturity status comparison demonstrated significant differences for all training load measures (F = 6.593 to 14.424, p = 0.000 to 0.037, η2 = 0.020–0.092). Interaction effects were found for age group x maturity band x relative age (Λ Pillai’s = 0.391, Λ Wilk’s = 0.609, F = 11.385, p = 0.000, η2 = 0.391) and maturity band x relative age (Λ Pillai’s = 0.252, Λ Wilk’s = 0.769, F = 0.955, p = 0.004, η2 = 0.112). Current research has confirmed the effects of chronological age, relative age, and biological maturation on accumulated training load. Perceived exertion does not seem to show any differences concerning age group or maturity status. Evidence should be helpful for professionals to optimize the training process and young football players’ performance.
Synthesis of Ce/Gd@HA/PLGA Scaffolds Contributing to Bone Repair and MRI Enhancement

It is important for future clinical applications to design and synthesize multipurpose scaffolding materials for bone tissue engineering with high osteogenic induction and MRI capability. In the present study, we synthesized Ce/Gd@HA by co-doping Ce3+ and Gd3+ into hydroxyapatite (HA) using a hydrothermal synthesis method, and then Ce/Gd@HA composites were synthesized by combining Ce/Gd@HA nanoparticles with polylactic-co-glycolic acid (PLGA) to investigate whether implanted Ce/Gd@HA/PLGA composites could promote osteoblast viability, leading to tibia repair of the rats and enhance MRI. The measurement results contain X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, and environmental scanning electron microscopy (ESEM) showing that HA doped with Ce3+ and Gd3+ was still a hexagonal crystal with high crystallinity. The synthesized Ce/Gd@HA/PLGA composites have a structure and obvious magnetic resonance imaging (MRI) capability. The in vitro experimental results indicated that Ce/Gd@HA/PLGA composites significantly promoted the performance of MC3T3-E1 cells, containing proliferation, adhesion, and osteogenic differentiation capacities. These include the improvement of alkaline phosphatase activity, enhancement of mineral deposition, and upregulation of OCN and COL-1 gene expression. The in vivo experimental results demonstrated that the Ce/Gd@HA/PLGA composites significantly improved the healing rate of rat bone defects. The MRI images indicated that the Ga-doped composites were observed in the MRI T1 sequence in rats. The aforementioned results suggested that Ce/Gd@HA/PLGA composites not only effectively promoted bone formation but also enhanced MRI capability. The composites synthesized in this study have great potential in bone regeneration with an extensive application in bone tissue engineering.
Qinggan Huoxue Recipe Alleviates Alcoholic Liver Injury by Suppressing Endoplasmic Reticulum Stress Through LXR-LPCAT3

Endoplasmic reticulum stress (ERS) plays a key role in alcohol liver injury (ALI). Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is a potential modifier of ERS. It was examined whether the protective effect of Qinggan Huoxue Recipe (QGHXR) against ALI was associated with LPCAT3 by suppressing ERS from in vivo and in vitro experiment. Male C57BL/6 mice were randomly divided into five groups (n = 10, each) and treated for 8 weeks as follows: the control diet-fed group (pair-fed), ethanol diet-fed group (EtOH-fed), QGHXR group (EtOH-fed + QGHXR), Qinggan recipe group (EtOH-fed + QGR), and Huoxue recipe group (EtOH-fed + HXR). QGHXR, QGR, and HXR groups attenuated liver injury mainly manifested in reducing serum ALT, AST, and liver TG and reducing the severity of liver cell necrosis and steatosis in ALI mouse models. QGHXR mainly inhibited the mRNA levels of Lxrα, Perk, Eif2α, and Atf4 and activated the mRNA levels of Lpcat3 and Ire1α, while inhibiting the protein levels of LPCAT3, eIF2α, IRE1α, and XBP1u and activating the protein levels of GRP78 to improve ALI. QGR was more inclined to improve ALI by inhibiting the mRNA levels of Lxrα, Perk, Eif2α, Atif4, and Chop and activating the mRNA levels of Lpcat3 and Ire1α while inhibiting the protein levels of LPCAT3, PERK, eIF2α, IRE1α, and XBP1u. HXR was more inclined to improve ALI by inhibiting the mRNA levels of Perk, Eif2α, Atf4, and Chop mRNA while inhibiting the protein levels of LPCAT3, PERK, eIF2α, IRE1α, and XBP1u and activating the protein levels of GRP78. Ethanol (100 mM) was used to intervene HepG2 and AML12 to establish an ALI cell model and treated by QGHXR-, QGR-, and HXR-medicated serum (100 mg/L). QGHXR, QGR, and HXR groups mainly reduced the serum TG level and the expression of inflammatory factors such as IL-6 and TNF-α in the liver induced by ethanol. In AML12 cells, QGHXR and its disassembly mainly activated Grp78 mRNA expression together with inhibiting Lxrα, Lpcat3, Eif2α, Atf4, and Xbp1 mRNA expression. The protein expression of eIF2α and XBP1u was inhibited, and the expression of PERK and GRP78 was activated to alleviate ALI. In HepG2 cells, QGHXR mainly alleviated ALI by inhibiting the mRNA expression of LPCAT3, CHOP, IRE1α, XBP1, eIF2α, CHOP, and IRE1α protein. QGR was more inclined to inhibit the protein expression of PERK, and HXR was more likely to inhibit the protein expression of ATF4.
Reflections on Some of the Exceptional Features of HTLV-1 and HTLV-1 Research: A Perspective

The report is not a review or a summary. In a manner, it is a perspective but an unusual one. It looks back to the years my colleagues and I (RG) began preparing for human retroviruses (beginning in 1970), how they evolved, and attempts to bring to light or simply to emphasize many exceptional characteristics of a retrovirus known as HTLV-1 and some fortuitous coincidences, with emphasis on the needs of the field. These events cover over one half a century. We have had many reviews on HTLV-1 disease, epidemiology, and basic aspects of its replication, genome, gene functions, structure, and pathogenesis, though continued updates are needed. However, some of its truly exceptional features have not been highlighted, or at least not in a comprehensive manner. This article attempts to do so.
Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest

Background Gastrointestinal (GI) symptoms are prominent in many patients with major depressive disorder (MDD). However, it remains unclear whether MDD patients with GI symptoms have brain imaging alterations in the default mode network (DMN) regions. Methods A total of 35 MDD patients with GI symptoms, 17 MDD patients without GI symptoms, and 28 healthy controls (HCs) were recruited. All participants underwent resting-state functional magnetic resonance imaging scans. Network homogeneity (NH) and support vector machine (SVM) methods were used to analyze the imaging data. Results Gastrointestinal group showed higher 17-item Hamilton Rating Scale for Depression total scores and factor scores than the non-GI group. Compared with the non-GI group and HCs, the GI group showed decreased NH in the right middle temporal gyrus (MTG) and increased NH in the right precuneus (PCu). The SVM results showed that a combination of NH values of the right PCu and the right MTG exhibited the highest accuracy of 88.46% (46/52) to discriminate MDD patients with GI symptoms from those without GI symptoms. Conclusion Major depressive disorder patients with GI symptoms have more severe depressive symptoms than those without GI symptoms. Distinctive NH patterns in the DMN exist in MDD patients with GI symptoms, which can be applied as a potential brain imaging marker to discriminate MDD patients with GI symptoms from those without GI symptoms.
The Role of the Crosstalk Between Gut Microbiota and Immune Cells in the Pathogenesis and Treatment of Multiple Myeloma

Around 10% of all hematologic malignancies are classified as multiple myeloma (MM), the second most common malignancy within that group. Although massive progress in developing of new drugs against MM has been made in recent years, MM is still an incurable disease, and every patient eventually has relapse refractory to any known treatment. That is why further and non-conventional research elucidating the role of new factors in MM pathogenesis is needed, facilitating discoveries of the new drugs. One of these factors is the gut microbiota, whose role in health and disease is still being explored. This review presents the continuous changes in the gut microbiota composition during our whole life with a particular focus on its impact on our immune system. Additionally, it mainly focuses on the chronic antigenic stimulation of B-cells as the leading mechanism responsible for MM promotion. The sophisticated interactions between microorganisms colonizing our gut, immune cells (dendritic cells, macrophages, neutrophils, T/B cells, plasma cells), and intestinal epithelial cells will be shown. That article summarizes the current knowledge about the initiation of MM cells, emphasizing the role of microorganisms in that process.
Systemic-Immune-Inflammation Index as a Promising Biomarker for Predicting Perioperative Ischemic Stroke in Older Patients Who Underwent Non-cardiac Surgery

Objective This study aimed to investigate the clinical prognostic values of the preoperative systemic-immune-inflammation index (SII) in older patients undergoing non-cardiac surgery, using perioperative ischemic stroke as the primary outcome. Methods This retrospective cohort study included older patients who underwent non-cardiac surgery between January 2008 and August 2019. The patients were divided into SII < 583 and SII ≥ 583 group according to the optimal SII cut-off value. The outcome of interest was ischemic stroke within 30 days after surgery. Primary, sensitivity, and subgroup analyses were performed to confirm that preoperative SII qualifies as a promising, independent prognostic indicator. Propensity score matching (PSM) analysis was further applied to address the potential residual confounding effect of covariates to examine the robustness of our results. Results Among the 40,670 included patients with a median age of 70 years (interquartile range: 67, 74), 237 (0.58%) experienced an ischemic stroke within 30 days after surgery. SII ≥ 583 was associated with an increased risk of perioperative ischemic stroke in multivariate regression analysis [odds ratio (OR), 1.843; 95% confidence interval (CI), 1.369–2.480; P < 0.001]. After PSM adjustment, all covariates were well balanced between the two groups. The correlation between the SII and perioperative ischemic stroke remained significantly robust (OR: 2.195; 95% CI: 1.574–3.106; P < 0.001) in the PSM analysis. Conclusion Preoperative SII, which includes neutrophil, platelet, and lymphocyte counts obtained from routine blood analysis, was a potential prognostic biomarker for predicting perioperative ischemic stroke after non-cardiac surgery in elderly older patients. An elevated SII, based on an optimal cut-off value of 583, was an independent risk factor for perioperative ischemic stroke.
Virtual communities of practice in simulation-based healthcare education: participation factors and content value assessment

This study is the first known formative analysis of simulation-based healthcare education virtual communities of practice (VCoPs). The goal of this study was to analyse the frequency of participation, factors that influence participation, and strategies used to assess the value and credibility of content in simulation-based healthcare education VCoPs. A sequential mixed-methods approach was used to assess participation and content assessment factors for a sample of 100 online survey respondents and five semi-structured interviews. Participation frequency was directly observed in 11 simulation-based education VCoPs for a one-year period between September 1, 2014 and August 31, 2015. Simulation-based healthcare education VCoPs that were hosted on LinkedIn had poor user engagement compared to VCoPs hosted as independent discussion forums. Qualitative analysis suggested that the perceived unmoderated and commercial nature of LinkedIn VCoPs may have driven low participation rates. Factors that were empirically associated with community participation rates included platform ease of use, trust in the community, direct and indirect personal benefits, self-efficacy and psychological safety. In this study, VCoPs participants rarely engaged in a systematic process of content credibility and value assessment. Rather, heuristic shortcuts were leveraged to assess content, including reputation, enforcement, self-confirmation, expectancy violation, and persuasive intent.
Impacts of construction activities on the environment : the case of Ghana

Construction activities impact on the environment throughout the life cycle of development. These impacts occur from initial work on-site through the construction period, operational period and to the final demolition when a building comes to an end of its life. Even though the construction period is comparatively shorter in relation to the other stages of a building's life, it has diverse significant impacts on the environment. This study investigates the major impacts of construction activities on the environment in Ghana. Thirty-three possible impacts of construction activities on the environment were identified from literature. These impacts were further categorized into nine major groups and were subjected to a cross-sectional survey. Questionnaire and interview were used to elicit the views of respondents. Questionnaires were distributed to 100 randomly selected construction practitioners made up of 58 architects, 37 quantity surveyors and 5 structural engineers registered with their professional bodies. Semi-structured interview was conducted amongst purposively selected contractors and consultants. The respondents were asked to identify the most important environmental impacts. The relative importance of the impacts identified were calculated and ranked by the relative importance index. According to the results of the study, the respondents agreed that resource consumption group impacts ranked highest among the major impacts of construction activities on the environment in Ghana. The resource consumption group impacts were raw materials consumption, electricity consumption, water consumption and fuel consumption. Biodiversity impact was second followed by local issues impacts. The paper recommends that stakeholders in the construction industry should come up with special legislations, codes or standards relating to sustainable construction practices specific to Ghana's construction environment and ensure proper and effective implementation.
Prognostic Factors and Treatment Efficacy in Spinal Cord Sarcoidosis

Background and Objectives Spinal cord sarcoidosis is a rare manifestation of sarcoidosis with a consequent risk of neurologic sequelae for the patient. We investigated prognostic factors and efficacy of immunosuppressive treatments in a longitudinal cohort. Methods We retrospectively studied patients with spinal cord sarcoidosis followed between 1995 and 2021 in 7 centers in France. Patients with definite, probable, or possible spinal cord sarcoidosis according to the Neurosarcoidosis Consortium Consensus Group criteria and with spinal cord involvement confirmed by MRI were included. We analyzed relapse or progression rate with a Poisson model, initial Rankin score with a linear model, and change in the Rankin score during follow-up with a logistic model. Results A total of 97 patients were followed for a median of 7.8 years. Overall mean relapse or progression rate was 0.17 per person-year and decreased over time. At last visit, 46 (47.4%) patients had a loss of autonomy (Rankin score ≥2). The main prognostic factors significantly associated with relapse or progression rate were gadolinium enhancement (relative rate [95% CI] 0.61 [0.4, 0.95]) or meningeal involvement (relative rate [95% CI] 2.05 [1.31, 3.19]) on spinal cord MRI and cell count (relative rate [95% CI] per 1 log increase 1.16 [1.01, 1.33]) on CSF analysis. Relapse or progression rate was not significantly associated with initial Rankin score or Expanded Disability Status Scale. Tumor necrosis factor–α (TNF-α) antagonists significantly decreased relapse or progression rate compared with corticosteroids alone (relative rate [95% CI] 0.33 [0.11, 0.98]). Azathioprine was significantly less effective than methotrexate on relapse or progression rate (relative rate [95% CI] 2.83 [1.04, 7.75]) and change in Rankin score (mean difference [95% CI] 0.65 [0.23, 1.08]). Discussion Regarding the relapse or progression rate, meningeal localization of sarcoidosis was associated with a worse prognosis, TNF-α antagonists resulted in a significant decrease compared to corticosteroids alone, and methotrexate was more effective than azathioprine. Classification of Evidence This study provides Class IV evidence that in individuals with spinal cord neurosarcoidosis, TNF-α antagonists were associated with decreased relapse or progression rate compared to corticosteroids alone, but other therapies showed no significant benefit.
NBER WORKING PAPER SERIES INEQUALITIES IN THE TIMES OF A PANDEMIC

This paper summarizes the research on some of the major inequalities that have been exacerbated by the COVID-19 pandemic across OECD countries. It reviews findings related to inequalities across the income distribution, sectors and regions, gender, and inequalities in education inputs for children from different socioeconomic backgrounds. Stefanie Stantcheva Department of Economics Littauer Center 232 Harvard University Cambridge, MA 02138 and NBER sstantcheva@fas.harvard. edu
Flight in nature I: Take-off in animal flyers

Abstract In this review paper, several take-off techniques of different species of animal flyers and gliders, both extinct and extant, are analysed. The methods they use vary according to animal group and size. Smaller animals, such as insects, rely on the use of transient aerodynamic techniques or the use of stored elastic energy. Medium-size flyers such as birds, bats, and other mammal gliders initiate flight by a jump which involves leg and wing movement coordination. The largest animals to fly, the extinct pterosaurs, are believed to have used a combination of aerodynamic and mechanic techniques in order to become airborne. The information presented here can be used as a resource for novel biomimetic unmanned aircraft design.
Maternal Obesity as a Risk Factor for Caesarean Section Delivery: A Case-control Study as a A Case-control Study.

Background: The rate of obesity is rising in Nepal and it has increased rapidly among women of reproductive age group over the last decade. Similarly, the rate of caesarean section has also shown an increasing trend in the country over the same period. The objective of this study was to identify maternal obesity as a risk factor for caesarean section in Kathmandu valley. Methods: An analytical case-control design was used to conduct the study. A total of 300 participants, 150 caesarean section deliveries as cases and 150 vaginal deliveries as age-matched controls were selected using purposive sampling technique. Data were collected through interview schedule using a semi-structured questionnaire and medical records review in Paropakar Maternity and Women's Hospital postnatal ward. The Pearson's chi-square test and odds ratio were used to test the association. Results: The study findings revealed a mean body mass index of 24.32±3.96 among the caesarean section delivery group and 21.94±3.34 among the vaginal delivery group (P< 0.001). Obesity was found in 44.67% of the caesarean section delivery group and 18.67% in the vaginal delivery group. There was a significant association between maternal obesity and caesarean section delivery with adjusted OR 4.14, 95% CI: 2.34-7.20 (P <0.001). should promote pre-conceptional dietary counselling, regular physical activity and a healthy lifestyle at all levels of health centres. Identification of obesity in the first antenatal visit must be encouraged and offered advice about ideal weight maintenance.
(Near) Substitute Preferences and Equilibria with Indivisibilities ∗

An obstacle to using market mechanisms to allocate indivisible goods is the non-existence of competitive equilibria (CE). To surmount this Arrow and Hahn proposed the notion of social-approximate equilibria: a price vector and corresponding excess demands that are ‘small’. We identify social approximate equilibria where the excess demand, good-by-good, is bounded by a parameter that depends on preferences only and not the size of the economy. This parameter measures the degree of departure from substitute preferences. As a special case, we identify a class called geometric substitutes that guarantees the existence of competitive equilibria in non-quasi-linear settings. It strictly generalizes prior conditions such as single improvement, no complementarities, gross substitutes and net substitutes.
Examining Factors Influencing Intention to Use E-Wallet in Indonesia

Nowadays e-wallet has become trend in Indonesia, especially since Covid-19. This is because e-wallet is fit with the Covid-19 protocol. The purpose of this research is to analyze the impact of perceived ease of use, perceived usefulness and compatibility towards intention to use e-wallet. Technology Acceptance Model (TAM) will be used to underpin the research framework. Data for this study will be collected among university students who live in Indonesia and are familiar with e-wallet using online survey-based research. The measurement for this study will be adapted from previous scholars and confirm its reliability and validity through pretesting process. Data will be analyze using SPSS and SmartPLS. The output of this study will contribute to the development of TAM in the context of intention to use e-wallet among university students in Indonesia. Moreover, the result also will give insight on the consumer behaviors related to e-wallet.