Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of E-Recruitment on Candidates’ Attitudes: A Study on Graduate Job Seekers of Bangladesh

Since the inception of 21st century, the world has been experiencing a tremendous application of information technology within the functional departments of the business organizations. HR, as the life blood of all functional departments, also tends towards using technology extensively. Electronic recruitment is the system of recruiting candidates through electronic sources is now widely practiced as part of the technology orientations. Notwithstanding having great influence of technology on recruitment in advanced countries, the country like Bangladesh is still unaware of the techniques and effects of e-recruitment. Fathoming the demand, this study aims at pinpointing the impact of e-recruitment on the attitude of graduate jobseekers in Bangladesh. Judgment sampling has been adopted to recruit the respondents from the graduate job applicants. Sample size deemed for the study was 227. Z-test, simple linear and multiple linear regression analysis were applied to analyze the data. The study reveals that internet is the most preferred source to search job. It also shows that the effectiveness of e-recruitment depends upon advertisement placement where perceived advantages and ease of use have significant impact on candidates’ intention to apply. The study might be proven crucial for the HR practitioners to understand the perceptions of potential candidates. At the same instance, the academicians are expected to find a new window to be explored.
The Secretome of Preconditioned Mesenchymal Stem Cells Drives Polarization and Reprogramming of M2a Macrophages toward an IL-10-Producing Phenotype

The preconditioning of mesenchymal stem cells (MSCs) has been recognized as an attractive tool to improve their regenerative and immunomodulatory capacities based on their paracrine effects. In this study, we examined the potential of an MSC-conditioned medium (MSC-CM) to alter the phenotype of murine macrophages and to drive reprogramming toward an anti-inflammatory, M2-like state in vitro. We further explored the impact of MSC cytokine preconditioning on the immunosuppressive properties of the MSC secretome. The MSC-CM suppressed the expression of proinflammatory genes in murine M1 macrophages, but only the CM from preconditioned MSCs (preMSC-CM) downregulated their expression during M1 polarization. Remarkably, only the preMSC-CM significantly increased the expression of M2a-, M2b- and M2c-specific genes and proteins during M2a polarization. Further, macrophages were found to secrete high levels of anti-inflammatory IL-10. Similarly, M2a macrophages cultured in the presence of the preMSC-CM displayed an enhanced expression of M2b/M2c-specific markers, suggesting that the secretome of preMSC promotes the repolarization of M2a-like macrophages to M2b/M2c subtypes. The preMSC-CM was found to be enriched in molecules involved in M2 polarization. Additionally, a unique downregulation of extracellular matrix components was observed. Altogether, the preMSC-CM may provide an attractive strategy to dampen inflammation by suppressing the expression of proinflammatory mediators and promoting the polarization and phenotype switch of M2a cells to IL-10-secreting M2b/M2c-like macrophages.
An Innovative Site-Specific Anti-HER2 Antibody-Drug Conjugate with High Homogeneity and Improved Therapeutic Index

Purpose Antibody-drug conjugates (ADCs) have emerged as a potent cancer therapeutic option in recent years. DP303c is a HER2-targeting ADC with a cleavable linker-MMAE payload. The current study aimed to evaluate the therapeutic potentials of DP303c in vitro as well as in vivo. Materials and Methods Size exclusion chromatography (SEC), reverse-phase high-performance liquid chromatography (RP-HPLC), and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were used to analyze the physicochemical characterization of DP303c. An enzyme-linked immunosorbent assay (ELISA), a cell-based assay, and bio-layer interferometry (BLI) were used to evaluate DP303c’s affinity with HER2 and Fc receptors. A confocal laser scanning microscopy was used to observe the internalization of DP303c. Antibody-dependent cell-mediated cytotoxicity (ADCC) and cytotoxicity assays were used to investigate the activity of DP303c in vitro. The antitumor activity of DP303c was assessed in vivo in the HER2-positive cell-derived xenograft model. Results DP303c was a site-specific anti-HER2 antibody-drug conjugate with a monomethyl auristatin E (MMAE) with an average drug-to-antibody ratio (DAR) of 2.0. DP303c showed a high affinity with HER2 and could be effectively internalized. In vitro and in vivo, DP303c showed stronger antitumor activity as compared to trastuzumab-DM1 (T-DM1) in a series of HER2-positive cancer cells and cell-derived xenograft (CDX) models, especially in the lower HER2-expressing cells. DP303c also exhibited high serum stability and a good PK profile. Conclusion DP303c was a steady and homogenous DAR 2 ADC that was predicted to deliver MMAE inhibitor to tumor cells. DP303c demonstrated remarkable anticancer efficacy against T-DM1 in xenograft models. DP303c was a strong candidate for the treatment of patients with HER2-positive cancer.
Pile foundations: Experimental investigations, analysis and design

Selected topics in the field of pile foundations are addressed. The effects of the installation technique on the bearing ca- pacity and the load-settlement response of a single pile are discussed. The latter effect is shown to be less significant; a settlement co ntrolled design is thus less dependent on the technological factors. Monitoring of the installation parameters shows some potential for controlling the pile response. The available experimental evidence on the behaviour of pile foundations under vertical loads (set- tlement, load sharing, bearing capacity), by monitoring of full scale structures or by research experiments, is reviewed. Simple em- pirical methods for a preliminary evaluation of the settlement are suggested. The (more limited) evidence about horizontal loading is also reviewed and discussed. The methods for the analysis of pile foundations under vertical load are next reported. They may be con- sidered satisfactory for engineering purposes, provided they are used paying due attention to the correspondence relations between theories and reality. The criteria for an optimum design, achieving maximum economy while keeping satisfactory performances, are di fferent for different kinds of pile foundations (small groups, large rafts). Safety against a bearing capacity failure, average settle- ment, differential settlement, moment and shear in the raft and cost are the quantities to be controlled. It is claimed that the conven- tional capacity based approach, still prevailing in practice, is not suited to develop a proper design. Present codes and regulations, es- sentially based on this approach, at the time being act as a restraint rather than a stimulus and need some revision.
Irrigation Water Management Tools and Alternative Irrigation Sources Trends and Perceptions by Farmers from the Delta Regions of the Lower Mississippi River Basin in South Central USA

This article describes the opinions and perceptions of farmers on water management tools that conserve groundwater and on alternative sources of water for irrigation. The analysis is based on a survey of producers (N=466) across the Lower Mississippi River Basin (LMRB) areas of Arkansas, Louisiana, Mississippi, and Missouri. Summary statistics of practice usage across the region and for each state are presented. A Poisson count model is applied to the data to identify factors that influence the number of groundwater-conserving practices employed. The number of irrigated acres, years of farming, annual income level, perception of groundwater problems, and participation in conservation programs have statistically significant association with the number of practices employed. Years of farming experience is the only factor negatively associated with the number of practices employed, while participation in conservation programs has the largest magnitude effect on that number. These results provide evidence that sponsored conservation programs increase the number of conservation practices adopted by farmers. This insight is useful for producer collectives, policy makers, and program managers to design and target of conservation programs across the LMRB.
Application of PRP in Chloasma: A Meta-Analysis and Systematic Review

Background Chloasma is a common skin pigment disorder. Treatment of chloasma has been challenging, often unsatisfactory, and difficult to avoid recurrence. PRP is a new treatment for chloasma, but there is no consensus on its use. Lingyun Zhao's team recently reported a systematic evaluation and meta-analysis of the efficacy and safety of PRP in the treatment of chloasma, which is consistent with our ideas, but we will elaborate on the application of PRP in chloasma from a deeper and more comprehensive perspective. Before we started this study, we had registered with Prospero as CRD42021233721. Methods The authors searched the public medical network, MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ScienceDirect, Scopus, and Science Network. The clinical trials registry ClinicalTrials.gov databases were searched for relevant publications to June 2021. The results showed the area and severity of chloasma (MASI) or revised MASI (mMASI) score. Results Three RCTs, one nonrandomized controlled study, and four were prospective before and after self-controlled studies met the inclusive criteria. Intradermal PRP injections significantly improved chloasma as indicated by the significant decrease MASI (average balance -6.71, 95% CI -8.99 to -4.33) and mMASI scores (average balance -2.94, 95% CI -4.81 to -1.07). The adverse reactions were mild, and there were no significant long-term adverse events. Conclusive. The data can reflect the effectiveness and safety of PRP therapy for chloasma. RCTs are needed to determine effective treatment parameters, and long-term follow-up should be included to better clarify the efficacy and side effects of PRP in treating chloasma.
Individual value orientation, social norms, and volunteering outcomes in later life

A growing body of scholarship examines the social and personal benefits of volunteering across the life course. However, less is known about how this experience of volunteering varies across different national contexts and how the impact of volunteering is shaped by micro- and macro-conditions. This article utilizes a cross-national multilevel regression analysis of European Values Survey data to explore the benefits of volunteering for two distinct sets of aging populations in the EU: those identified as “materialists” and “postmaterialists. ” It finds that a positive association between volunteering and one key indicator of quality of life (“control over life”) generally exists for postmaterialists, while it is more positive in countries with stronger familial norms among materialists. Hence, the role of volunteering in later life is not as uniform as suggested by the active aging approach.
Management of Lateral Epicondylitis: A Prospective Comparative Study Comparing the Local Infiltrations of Leucocyte Enriched Platelet-Rich Plasma (L-aPRP), Glucocorticoid and Normal Saline

Introduction: Lateral epicondylitis is a painful condition of the elbow, characterised by pain and tenderness with resisted wrist extension. This study was carried out to evaluate the comparative efficacy of the local infiltration of L-PRP, methylprednisolone and normal saline in patients with lateral epicondylitis. Materials and methods: Sixty adult patients, between the ages 30 to 50 years, diagnosed with lateral epicondylitis of more than 12 weeks, were enrolled in the prospective randomised study. Their medical history and previous conservative treatment were recorded; the clinical evaluation of the tendinitis was made with the visual analogue scale (VAS), the disabilities of the arm, shoulder, and hand (DASH) outcome scores, the modified elbow performance index (MEPS), the functional assessment by patient-rated tennis elbow evaluation (PRTEE), together with the laboratory investigations. The patients were randomised using the computer-generated alphabets into three groups of 20: group A received saline, group B received PRP, and group C received corticosteroids. Results: Patients were seen at 4, 8 and 12 weeks to evaluate the post-injection status. VAS, DASH, and PRTEE scores were significantly reduced, and MEPS was significantly improved in group B compared to group A and group C. Moreover, the reductions in VAS and PRTEE were significantly different in group C compared to group A. Conclusion: PRP leads to superior healing with long-term therapeutic advantages compared to corticosteroids though it takes a little longer to have its effect.
Science of 2.5 dimensional materials: paradigm shift of materials science toward future social innovation

ABSTRACT The past decades of materials science discoveries are the basis of our present society – from the foundation of semiconductor devices to the recent development of internet of things (IoT) technologies. These materials science developments have depended mainly on control of rigid chemical bonds, such as covalent and ionic bonds, in organic molecules and polymers, inorganic crystals and thin films. The recent discovery of graphene and other two-dimensional (2D) materials offers a novel approach to synthesizing materials by controlling their weak out-of-plane van der Waals (vdW) interactions. Artificial stacks of different types of 2D materials are a novel concept in materials synthesis, with the stacks not limited by rigid chemical bonds nor by lattice constants. This offers plenty of opportunities to explore new physics, chemistry, and engineering. An often-overlooked characteristic of vdW stacks is the well-defined 2D nanospace between the layers, which provides unique physical phenomena and a rich field for synthesis of novel materials. Applying the science of intercalation compounds to 2D materials provides new insights and expectations about the use of the vdW nanospace. We call this nascent field of science ‘2.5 dimensional (2.5D) materials,’ to acknowledge the important extra degree of freedom beyond 2D materials. 2.5D materials not only offer a new field of scientific research, but also contribute to the development of practical applications, and will lead to future social innovation. In this paper, we introduce the new scientific concept of this science of ‘2.5D materials’ and review recent research developments based on this new scientific concept. GRAPHICAL ABSTRACT
FLAX-TRM for the In-Plane Shear Strengthening of Masonry

The present study investigates the use of Flax Textile-Reinforced Mortars (FTRM) as a strengthening and seismic retrofitting solution for unreinforced masonry. The FTRM system comprised flax textiles embedded in lime-based mortar and was externally bonded to the surface of four medium-scale masonry walls on both sides, in strengthening configurations including one and two FTRM layers. One bare wall and one wall strengthened only with lime-based mortar were additionally examined as reference samples. All specimens were tested in in-plane shear under quasi-static cyclic loading conditions, while axial load equal to 10% of the masonry compressive strength was constantly applied throughout the test. The effectiveness of the developed FTRM system is assessed in terms of strength, deformability, energy dissipation and failure modes. The obtained results highlight the promising potential of this system as an in-plane strengthening solution for masonry, with FTRM-retrofitted specimens able to promote strain redistribution and ensure the structural integrity. Two-layer configurations were evidenced to sustain up to 118% higher load capacity, improved ductility, and provided significant energy dissipation capacity.
Adherence to COVID-19 Preventive Behaviours: the Implication of Life Orientation and Sociodemographic Factors among Residents in Nigeria

There is a sporadic increase in the number of newly infected cases of COVID-19 in Nigeria and this conveys clearly, poor adherence to the preventive guidelines by WHO and NCDC. This study examined the roles of life orientation and socio-demographic factors on adherence to COVID-19 preventive behaviours among residents in Nigeria. Using an ex post facto design, 798 residents in Nigeria (M = 303, F = 485) responded to an online survey measuring the socio-demographics, Life Orientation Test-Revised (LOT-R) and validated adherence to COVID-19 preventive behaviours. Two research hypotheses were formulated and tested using t-test of independent samples and ANCOVA. Results revealed that life orientation had a significant influence on adherence to preventive behaviour during the COVID-19 outbreak, [t (796) = 14.72; p < . 001], such that respondents with optimistic life orientation adhered more significantly ( X = 14.25, SD = 1.71) than respondents with pessimistic life orientation ( X = 10.28, SD = 3.20). Furthermore, respondents’ age [F (1, 753) = 04.69, p < . 05; = . 01]; sex, F (1, 753) = 06.07, p < . 05; education, [F (5, 753) 11.70, p η and marital status, [F 753) 3.84, p η independently influenced adherence to COVID-19 preventive behaviours. The study concluded that life orientation and socio-demographic factors have serious implications for research efforts and policymaking in ensuring that people adhere to COVID-19 preventive behaviours in Nigeria.
Generalized medians and electoral competition with valence

I establish conditions for existence of pure strategy equilibria in K-candidate Downsian electoral competition (K ≥ 2) with valence when the voting rule is monotonic, generalizing existing results to non-proper rules and possibly continuous electorates. The conditions are sufficient when K ≥ 2 and (essentially) necessary in the K = 2 candidate case. They compare the size of one candidate's valence advantage to the radius of a generalized median pivotal ball (P-ball). I flesh out the difference of this generalized median with a recent alternative which, in turn, I characterize both on the basis of a weaker median property and using pivotal hyperplanes.
High Gain 100-GHz Antenna Array Based on Mixed PCB and Machining Technique

A W-band 8×8 slot-enhanced antenna array with high gain and high aperture efficiency is proposed based on the mixed printed circuit board (PCB) and machining technique. The antenna array consists of sixteen 2×2 antenna subarrays. The substrate integrated waveguide (SIW) cavity is used to feed the antenna subarray, where electromagnetic fields distribute in the TE220 mode. The SIW cavity is fabricated by the PCB technology for low-cost, low-profile, and light weight. To reduce the loss of the feeding network, a constant-amplitude in-phase power divider based on ridge gap waveguide (RGW) is adopted to feed the SIW subarray using machining technique. Besides, the standard WR-10 waveguide to RGW transition structure is designed for measurement. The entire antenna array is integrated and packaged in a metal box. The measured results show that the impedance bandwidth of the antenna array is 97.8-107 GHz with reflection coefficient lower than -10 dB. Within the impedance bandwidth, the antenna array gain is higher than 24.0 dBi, and the peak gain is 26.5 dBi. Moreover, aperture efficiency of the antenna is larger than 75%.
Determinants of Intrauterine Contraceptive Device Discontinuation Among Women Using Family Planning, in Southwest Ethiopia: Unmatched Case–Control Study

Background Although the intrauterine contraceptive device is an effective, reliable, safe, and recommended contraceptive method, it is still underutilized and has a high discontinuation rate in Ethiopia. The study aims to assess determinants of the discontinuation of IUCDs among women using family planning in Ilu Aba Bor Zone. Methods A facility-based unmatched case–control study was conducted from September to October, 2021 among 168 (56 cases and 112 controls) IUCD-user women in public health facilities in south-west Ethiopia. Pretested, structured and interviewer administered questionnaires were used for data collection. The data were coded, cleaned and entered to Epi-data version 3.1 and exported to SPSS version 23 for advanced analysis. A binary logistic regression was used to estimate the degree of association between the outcome variable and independent variables. Finally, variables with a p-value less than 0.05 at 95% confidence interval were declared as statistically significant with outcome variable. Results A total of 168 (163) respondents participated in the study, with a response rate of 97%. The mean (+SD) age of the respondents was 31.36 ± 5.916. Regarding the educational status of respondents about 36 (64.3%) of cases and 90 (84.1%) of controls have formal education, and about 42 (75%) of cases’ husbands and 97 (90.65%) of controls’ husbands have formal education, respectively. Experiencing side effects (AOR = 2.36; 95% CI: 1.01, 5.55), lack of follow up (AOR = 4.069; 95% CI: l.30, 12.69), and planning for next pregnancy (AOR 4.14; 95% CI: 1.58, 10.88) were found to be the main determinants of intrauterine device discontinuation. Conclusion The findings of the study showed that lack of follow-up after insertion of the IUCD, experiencing side effects, and having a plan for the next pregnancy were found to be the main determinants of intrauterine device discontinuation. Hence, arranging recommended regular follow-up and treating side effects are very important to sustain intrauterine device utilization.
How Should We Ring the Closing Bell? Determining Optimal Closing Auction Design

We examine how stock market closing price mechanisms aﬀect liquidity, price ef-ﬁciency, and market integrity. Using hand-collected data on every major mechanism change in 45 markets during 17 years, we ﬁnd that replacing simple mechanisms such as the last traded price with a closing auction typically improves market quality. However, auction design substantially impacts auction eﬀectiveness – price stabilization features and randomized closing times are beneﬁcial, whereas transparent indicative closing prices are often detrimental. The eﬀects vary with the level of market development and liquidity, suggesting that when designing optimal closing mechanisms, there is no “one size ﬁts all”.