Miracle-dz/UniFAR-FTUs huggingface dataset:
Heterogeneous Responses to Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs) in Patients with Uncommon EGFR Mutations: New Insights and Future Perspectives in this Complex Clinical Scenario

Uncommon Epidermal Growth Factor Receptor (EGFR) mutations represent a distinct and highly heterogeneous subgroup of Non-Small Cell Lung Cancers (NSCLCs), that accounts for approximately 10% of all EGFR-mutated patients. The incidence of uncommon EGFR mutations is growing, due to the wider adoption of next-generation sequencing (NGS) for diagnostic purposes, which enables the identification of rare variants, usually missed with available commercial kits that only detect a limited number of EGFR mutations. However, the sensitivity of uncommon mutations to first- and second-generation EGFR Tyrosine Kinase Inhibitors (TKIs) is widely heterogeneous and less well known, compared with classic mutations (i.e., exon 19 deletions and exon 21 L858R point mutation), since most of the pivotal studies with EGFR TKIs in the first line, with few exceptions, excluded patients with rare and/or complex variants. Recently, the third generation EGFR TKI osimertinib further revolutionized the therapeutic algorithm of EGFR-mutated NSCLC, but its role in patients harboring EGFR mutations besides exon 19 deletions and/or L858R is largely unknown. Therefore, a better knowledge of the sensitivity of uncommon mutations to currently available EGFR TKIs is critical to guiding treatment decisions in clinical practice. The aim of this paper is to provide a comprehensive overview of the treatment of NSCLC patients harboring uncommon EGFR mutations with currently approved therapies and to discuss the emerging therapeutic opportunities in this peculiar subgroup of patients, including chemo-immunotherapy combinations, next-generation EGFR TKIs, and novel targeted agents.
Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth into Retinal Photoreceptor-Like Cells and Their Sustainability In Vivo

Retinal degeneration is characterized by the progressive loss of photoreceptors, and stem cell therapy has become a promising strategy. Many studies have reported that mesenchymal stem cell transplantation can sustain retinal structure and prolong retinal functions based on two mechanisms. One is cell replacement, and the other is the paracrine action of stem cells. Cells from human exfoliated deciduous teeth (SHEDs) show characteristics typical of mesenchymal stem cells. They are derived from the neural crest and are a potential cellular source for neural regeneration in stem cell therapy. In this study, we explored the potential of SHEDs to be induced towards the retinal photoreceptor phenotype and to be sustainable in an animal model of retinal degeneration. A factor-cocktail protocol was used to induce SHEDs towards retinal photoreceptors for 24 days, and the characteristics of the induced cells were identified in terms of morphological changes, biomarker expression and subcellular distribution, and calcium influx. SHEDs were labeled with firefly luciferase for in vivo tracking by bioluminescent imaging and then transplanted into the subretinal space of mice. Our results showed that SHEDs successfully transdifferentiated into photoreceptor-like cells, which displayed neuron-like morphology, and expressed specific genes and proteins associated with retinal precursors, photoreceptor precursors, and mature photoreceptors. In addition, calcium influx was significantly greater in the retinal-induced than in noninduced SHEDs. In vivo tracking confirmed at least 2 weeks of good survival by bioluminescent imaging and 3 months of sustainability of SHEDs by histological analysis. We conclude that SHEDs have the potential to transdifferentiate into retinal photoreceptor-like cells in vitro and maintain good viability in vivo after transplantation into mice with a normal immune system. This demonstrates preliminary success in generating photoreceptor-like cells from SHEDs and applying SHEDs in treating retinal degeneration.
Functional Connectivity Pattern Analysis Underlying Neural Oscillation Synchronization during Deception

To characterize system cognitive processes during deception, event-related coherence was computed to investigate the functional connectivity among brain regions underlying neural oscillation synchronization. In this study, 15 participants were randomly assigned to honesty or deception groups and were instructed to tell the truth or lie when facing certain stimuli. Meanwhile, event-related potential signals were recorded using a 64-channel electroencephalography cap. Event-related coherence was computed separately in four frequency bands (delta (1-3.5 Hz), theta (4-7 Hz), alpha (8-13 Hz), and beta (14-30 HZ)) for the long-range intrahemispheric electrode pairs (F3P3, F4P4, F3T7, F4T8, F3O1, and F4O2). The results indicated that deceptive responses elicited greater connectivities in the frontoparietal and frontotemporal networks than in the frontooccipital network. Furthermore, the deception group displayed lower values of coherence in the frontoparietal electrode pairs in the alpha and beta bands than the honesty group. In particular, increased coherence in the delta and theta bands on specific left frontoparietal electrode pairs was observed. Additionally, the deception group exhibited higher values of coherence in the delta band and lower values of coherence in the beta band on the frontotemporal electrode pairs than did the honesty group. These data indicated that the active cognitive processes during deception include changes in ensemble activities between the frontal and parietal/temporal regions.
Development of a Dietary Factor Assessment Tool for Evaluating Associations between Visceral Fat Accumulation and Major Nutrients in Japanese Adults

Background and Objectives The increased prevalence of metabolic syndrome necessitates the establishment of tools for evaluating dietary factors associated with visceral fat accumulation and preventing visceral fat obesity. Here, we aimed to develop a dietary factor assessment tool for evaluating visceral fat accumulation. Methods We conducted a dietary habit questionnaire survey and visceral fat measurement by bioelectrical impedance analysis in 11,438 adults (Survey 1) and a dietary habit questionnaire survey and dietary assessment based on 3-day meal records in 579 adults (Survey 2). Dietary habit factors were identified by factor analysis with varimax rotation, and their relationship with visceral fat accumulation and major nutrients were analyzed. Results Factor analysis of the dietary habit questionnaire revealed the following five main dietary factors: “Appetite (15 questions),” “Healthy food choice (5 questions),” “Sedentary behavior (6 questions),” “Calorie restriction (5 questions),” and “Irregular mealtime (4 questions). ” “Appetite” correlated positively with visceral fat accumulation and energy intake mainly from carbohydrate. “Healthy food choice” correlated negatively with visceral fat accumulation and positively with the protein/fat ratio, dietary fiber/carbohydrate ratio, and N-3 fatty acid/fat ratio. Dietary guidance to modify excess energy intake and increase nutritional balance might be effective toward preventing visceral fat accumulation. Conclusions The dietary factor assessment tool developed in this study can be used to diagnose problems related to dietary habits and provide guidance for dietary modifications aimed at preventing visceral fat accumulation.
Smoothing Spline ANOVA for Time-Dependent Spectral Analysis

In this article we propose a smoothing spline ANOVA model (SS-ANOVA) to estimate and to make inference on the time-varying log-spectrum of a locally stationary process. The time-varying spectrum is assumed to be smooth in both time and frequency. This assumption essentially turns a time-frequency spectral estimation problem into a 2-dimensional surface estimation problem. A smooth localized complex exponential (SLEX) basis is used to calculate the initial periodograms, and a SS-ANOVA is fitted to the log-periodograms. This approach allows the time and frequency domains to be modeled in a unified approach and jointly estimated. Inference procedures, such as confidence intervals, and hypothesis tests proposed for the SS-ANOVA can be adopted for the time-varying spectrum. Because of the smoothness assumption of the underlying spectrum, once we have the estimates on a time-frequency grid, we can calculate the estimate at any given time and frequency. This leads to a high computational efficiency, because for large datasets we need only estimate the initial raw periodograms at a much coarser grid. We study a penalized least squares estimator and a penalized Whittle likelihood estimator. The penalized Whittle likelihood estimator has smaller mean squared errors, whereas inference based on the penalized least squares method can adopt existing results. We present simulation results and apply our method to electroencephalogram data recorded during an epileptic seizure.
Quantifying uncertainties in signal position in non-resolved images : application to space object observation

Charged Coupled Devices (CCDs) and subsequently Complementary metaloxidesemiconductor (CMOS) detectors revolutionized scientific imaging. On both the CCD and CMOS detector, the incoming photons release photo electrons that are then read out to produce an image. Unfortunately the generated images are degraded by inevitable noise introduced by the stochastic nature of the electron emission process and the read out process. Moreover, in many applications, such as in astronomy or for satellite tracking, only unresolved object images are available due to optical diffraction. It therefore is of integral interest to determine the center or so-called centroid of the non-resolved signal with a sub-pixel precision . The most common method for centroid estimation is to fit Gaussians or other parametrized surfaces to the signal in order to find the center of mass of the light. Because of the detector noise, the centroid estimate is necessarily uncertain. While the uncertainty in the centroid is classically estimated by running prohibitively costly Monte Carlo simulations, in this paper, we propose analytic uncertainty estimates of the centroid position. The expressions that depend on the pixel size, the signal to noise ratio and the extension of the object signal relative to the pixel size are validated against rigorous Monte Carlo simulations with very satisfying results. Numerical tests ∗Corresponding author. Tel. : +33(0)5 24 57 41 12 Email address: francois.sanson@inria.fr (Francois Sanson) Preprint submitted to Advances in Space Research April 18, 2018 show that our analytic expression is an efficient substitute to the Monte Carlo simulation thereby reducing computational cost.
biology of length weight relationship and condition factor of some cichlids in eleyele lake oyo state nigeria

The study was carried out to evaluate length-weight relationship and condition factor of five species of cichlids found in Eleyele Lake. Five species that were found throughout the study period are Tilapia zilli, Tilapia guineensis, Hemichromis fasciatus, Oreochromis niloticus and Sarotherodon melanotheron. The relationship between the length and weight of the fish spe cies showed that they are allometric in growth and this implies that the fish species did not increase in weight faster than the cube of their lengths. The mean condition factor for the five species is 2.8 for Tilapia zilli, 2.3 for Sarotherodon melanotheron, 2.7 for Tilapia guineensis , 2.2 for Oreochromis niloticus and 2.1 for Hemichromis fasciatus . The study revealed that Hemichromis fasciatus and Oreochromis niloticus and Tilapia zilli dominated the lake during the study period.
Explorer Technology Informatics Guiding Education Reform – TIGER

Citation for published version: Hübner, U, Shaw, T, Thye, J, Egbert, N, Marin, H, Chang, P, O’Connor, S, Day, K, Honey, M, Blake, R, Hovenga, E, Skiba, D & Ball, M 2018, 'Technology Informatics Guiding Education Reform – TIGER: An international recommendation framework of core competencies in Health Informatics for nurses' Methods of Information in Medicine, vol. 57, no. S 01, pp. e30-e42. DOI: 10.3414/ME17-01-0155
How the Perception of Athletic Academic Services affects the overall College Experience of Freshmen Student-Athletes

More and more intercollegiate athletics programs are allocating strategic resources toward building attractive athletics facilities, lavish training and academic complexes, and high-quality support services. Strategic investments in these areas continue to be a high priority for major college athletics programs, all with the hopes of enhancing the overall college experience for student-athletes. As such, researchers have begun to examine the role these various support services play in the overall athletic program. In this aim, the present study seeks to understand how academic support services are successful in enhancing this experience. Findings indicate that freshmen student-athletes’ perceptions of service quality provided by their academic athletic services influence satisfaction, student involvement, and emotional adjustment. Building from these findings, university athletic departments should reevaluate and adjust their academic services based on the perception of student-athletes and how the provided services influence their overall college experience.
When Competence Is Irrelevant: The Role of Interpersonal Affect in Task-Related Ties

This paper examines the role of a person's generalized positive or negative feelings toward someone (interpersonal affect) in task-related networks in organizations. We theorize that negative interpersonal affect renders task competence virtually irrelevant in a person's choice of a partner for task interactions but that positive interpersonal affect increases a person's reliance on competence as a criterion for choosing task partners, facilitating access to organizational resources relevant to the task. Using social psychological models of interpersonal perception and hierarchical Bayesian models, we find support for this theory in social network data from employees in three organizations: an entrepreneurial computer technology company, staff personnel at an academic institution, and employees in a large information technology corporation. The results suggest that competence may be irrelevant not just when outright dislike colors a relationship. Across organizational contexts and types of task-related interaction, people appear to need active liking to seek out the task resources of potential work partners and fully tap into the knowledge that resides in organizations. We discuss contributions of our study to research on the interplay of psychological and structural dimensions of organizational life.
The Effect of Cultural Heritage Tourism on Tourist Word of Mouth: The Case of Lok Versa Festival, Pakistan

Festivals are the most viable source of tourism promotion and provide recognition to different cultures and communities. This paper proposed and examined a holistic model of festival word of mouth (WOM), which is influenced by authenticity, promotion, loyalty, quality, and satisfaction. Accordingly, the current paper investigated the effect of the proposed model with reference to Lok Virsa handicrafts, the most famous festival of the Islamabad region in Pakistan. The findings revealed that the festival quality has direct impact on WOM and promotion. Promotion has a positive influence on loyalty, satisfaction, and WOM. Festival authenticity strongly influences promotion, quality, satisfaction, and WOM. Festival satisfaction is positively related to WOM and loyalty. Whereas, festival loyalty and WOM are significantly associated. The results suggest that festival organizers should deliver the claims and promises in the festival that they have made with tourists. This technique will harvest positive WOM and increase tourist re-visitation to upcoming festivals.
Controversy Over Voluntary Environmental Standards: A Socioeconomic Analysis of the Marine Stewardship Council

Voluntary standards certifying environmental qualities of labeled products have proliferated across sectors and countries. Effectuating these standards requires the collaboration among and between creators (typically firms and nongovernmental organizations) and adopters (firms across a particular supply chain). However, the need to collaborate does not rule out the presence of controversy. Drawing on the case of the Marine Stewardship Council, a leading seafood standard to conserve the world’s threatened marine fauna, we analyze how this controversy, from economic and sociologic vantage points, impacts a sustainability transition. In essence, interest divergence drives controversy over standard design, which spurs controversy over standard effectiveness and prompts the proliferation of competing standards. Controversy is magnified by the opacity or nontransparency of the fields which such standards seek to govern. We conclude that, while interest divergence and field opacity entail inherent controversy over voluntary environmental standards, the impact of this controversy on sustainability transitions is typically predominantly positive.
Improving eating quality and carotenoid content of squash.

The fruit of most cultigens of Cucurbita maxima and C. moschata squash are high in carotenoids, especially B-carotene and lutein, both of which are important nutritionally. However, there have been no systematic studies to quantify the amount and types of carotenoids in fruit tissues of breeding germplasm and popular cultivars. In the summer of 2007, seven inbred lines of C. maxima and two op cultivars and five inbred lines of C. moschata were grown in replicated plots at research farms in Durham and Madbury, New Hampshire (USA). Data were recorded at harvest and after 30 and 60 days of storage at 15C on % mesocarp dry weight (DW) and soluble solids (SS), both major attributes for determining acceptable eating quality. A visual estimation of carotenoid content was made using a Roche egg yolk color fan, with color hues numbered one (light yellow) to 15 (dark orange). At harvest, 49 to 57 days after pollination (DAP), mean mesocarp DW varied from 25.5 to 37 % and SS from 9.3 to 10.8 % among the seven C. maxima breeding lines. After storage for 30 d, four of the seven lines had SS levels above 11 %, deemed acceptable for good eating quality. In five lines with green rind, Roche color fan carotenoid values varied from 7 to 9 (medium yellow), while two lines with orange rind showed yellow-orange hues (11 to 12). After 30 d of storage all lines showed color values of 11 to 11.5, and color remained fairly stable up to 60 d of storage. In C. moschata cultigens, mean DW at harvest ranged between 20 and 24.3 % for all but one cultigen having low dry matter (16.8 %). Average SS was low, 7.0 to 8.7 % among all cultigens. Even after 60 d of storage, SS values were only above 11 % for three of the seven cultigens. At harvest Roche color values were 9 or lower for all but one cultigen. For most cultigens, color values increased progressively during 30 and 60 d of storage, and after 60 days all cultigens displayed a color value of 11 or greater. INTRODUCTION There are three major species of squash that are grown worldwide for their mature, edible fruit – Cucurbita pepo, C. maxima, and C. moschata. The species C. moschata includes tropical cultigens, round, oval and long-neck pumpkins grown in parts of North America for processing, and popular dumbbell-shaped butternut varieties, highly regarded for excellent shelf life. Within the species C. maxima, the most widely grown cultigens in North America include the humongous show pumpkins, large Golden Delicious-type processing squash, and the green to gray, 1 to 2 kg buttercup/kabocha varieties, the latter esteemed for their exceptional eating Cucurbitaceae 2008, Proceedings of the IX EUCARPIA meeting on genetics and breeding of Cucurbitaceae (Pitrat M, ed), INRA, Avignon (France), May 21-24, 2008
Impact of Treatment Time on Outcome for Resected Head and Neck Squamous Cell Carcinoma by HPV Status

Background and Purpose: Prior investigations have demonstrated an inverse correlation between the interval from resection of head and neck squamous cell carcinoma (HNSCC) to radiotherapy (RT) completion (overall treatment time; OTT) and disease control. However, the importance of OTT in human papillomavirus (HPV)-associated HNSCC remains to be determined. This study evaluates whether OTT remains independently associated with cancer control when evaluated by HPV association. Material and Methods: The data of HNSCC patients treated with curative-intent surgical resection followed by RT were collected. Univariable and multivariable analyses were used to assess the effects of HPV association and OTT. Results: From 2002-2014, 73 eligible patients were identified (36 HPV-associated). The median OTT was 94 days (range, 69-185, with no difference between HPV subgroups). At a median follow-up of 34.9 months (range, 2.6-162.2), 21 patients experienced disease failure, and 25 died. HPV-association was linked to improved disease-free survival (DFS), disease-specific survival (DFS), and overall survival (OS) by univariable and multivariable analyses. OTT was associated with improved DFS by univariable and multivariable analyses. Conclusion: OTT remains significantly associated with cancer control in the setting of HPV-associated disease. Efforts should be made to minimize the delay between resection and completion of RT for all HNSCC patients.
Plug Source and Growth Retardants Affect Finish Size of Bedding Plants

Eight bedding plant species were grown from plugs obtained from two sources. The plugs were transplanted into jumbo six packs and sprayed with a solution of chlormequat/daminozide with concentrations of 1000/800, 1250/1250, or 1500/5000 mg·L -1 when new growth was ≈5 cm in height or width. Three different species were grown in the fall (Dianthus chinensis L., 'Telstar Mix', Petunia × hybrida Hort. Vilm.- Andr., 'Dreams Red', and Viola × wittrockiana Gams., 'Bingo Blue'), winter ( Antirrhi- num majus L., 'Tahiti Mix', Matthiola incana (L.) R. Br. , 'Midget Red', and P. × hybrida, 'Dreams Mix'), and spring ( Catharanthus roseus (L.) G. Don, 'Cooler Pink', Salvia splendens F. Sellow ex Roem. & Schult. , 'Empire Red', and Begonia × semperflorens- cultorum Hort. , 'Cocktail Mix'). The treatments significantly reduced finished plant size of all species for each season. There was a significant difference in finish size between sources for Dianthus, Antirrhinum, Matthiola, Catharanthus, Salvia, and Bego- nia. The efficacy of chlormequat/daminozide also differed for each source of Dianthus, Matthiola, and Begonia, but the treatments minimized the differences in finish size between sources for Petunia and Viola. Chemical names used: (2-chlorethyl) trimethylammonium chloride (chlormequat); (N-dimethylaminosuccinamic acid) (daminozide).
Real-time Simulations and Experiments on Surface Acoustic Wave Scattering in Periodic Microstructures

Surface acoustic wave scattering in periodically microstructured surfaces is investigated numerically and experimentally. We perform the simulations by a real-time finite element technique and experiments by ultrashort pulsed optical excitation and interferometric detection. Good agreement is obtained between simulation and experiment. Our results clearly show the opening of phononic stop bands of the excited Rayleigh-like waves at the Brillouin zone boundary. In addition, we investigate the influence of the grating thickness by numerical simulations. Our results show the strong influence of the grating thickness on the position and width of the phononic stop bands.