Miracle-dz/UniFAR-FTUs huggingface dataset:
Do beliefs in the malleability of well‐being affect the efficacy of positive psychology interventions? Results of a randomized placebo‐controlled trial

Abstract The present study examines the role of beliefs about the malleability of well‐being in a randomized, placebo‐controlled, online positive psychology intervention targeting 267 German‐speaking adults (83% women, mean age = 43.16 years). The participants of the experimental group (“three good things” intervention) and placebo control group (“early memories”) reported their levels of happiness before and immediately after the 1‐week intervention, as well as 2, 4, and 12 weeks after the intervention. Furthermore, the researchers recorded how participants completed the exercises and to what extent they liked the exercises. This study also assesses the participants' beliefs surrounding two different aspects of malleability (well‐being is modifiable in general, and one knows how to change their well‐being). Although both aspects of malleability were strongly intercorrelated, beliefs about how to change one's well‐being seemed particularly relevant in the context of positive psychology interventions: Those who reported a stronger belief about how to change their well‐being liked the intervention better and more often completed the activity as instructed. Further, they reported greater increases in well‐being as compared with the control group. We conclude that beliefs about the malleability of well‐being might represent an important moderating variable in the effectiveness of positive psychology interventions.
Real-World Outcomes of Gemcitabine, Cisplatin, and Nab-Paclitaxel Chemotherapy Regimen for Advanced Biliary Tract Cancer: A Propensity Score-Matched Analysis

Background/Aims Advanced biliary tract cancer (BTC) is associated with poor survival. A recent phase II study of triplet combination chemotherapy, including gemcitabine, cisplatin, and nanoparticle albumin-bound (nab)-paclitaxel, has shown promising results. This study aimed to compare the efficacy of triplet and standard doublet chemotherapy in a real-world setting. Methods Patients with advanced BTC treated with triplet and doublet chemotherapy regimens were recruited. The propensity-score nearest neighbor matching method with a ratio of one-to-one was used to create a matched cohort for comparison. Progression-free survival (PFS), overall survival (OS), and safety profiles were examined in both groups. Results A total of 68 patients (n=34 per group) were included in the matched cohort, and their baseline characteristics were well balanced. Survival outcomes in the triplet chemotherapy group were not better than those in the doublet chemotherapy group, with a median PFS of 7.5 months (95% confidence interval [CI], 4.1 to 10.9) versus 7.2 months (95% CI, 5.6 to 8.9) (hazard ratio [HR], 0.93; 95% CI, 0.53 to 1.62; p=0.793) and a median OS of 13.7 months (95% CI, 8.8 to 18.7) versus 12.2 months (95% CI, 8.4 to 16.0) (HR 0.73; 95% CI, 0.38 to 1.41; p=0.354), respectively. In addition, the treatment-related severe adverse events, such as neutropenia, were more common in the triplet chemotherapy group. Conclusions Gemcitabine, cisplatin, and nab-paclitaxel did not improve the PFS or OS compared to that achieved by standard chemotherapy in patients with advanced BTC. The benefits of triplet chemotherapy in advanced BTC require examination in large randomized controlled trials. Key Words Biliary tract cancer; Gemcitabine; Cisplatin; Albumin-bound paclitaxel
Determinants and trends of COVID-19 vaccine hesitancy and vaccine uptake in a national cohort of U.S. adults: A longitudinal study

Abstract We estimated the trends and correlates of vaccine hesitancy, and its association with subsequent vaccine uptake among 5,458 adults in the United States. Participants belonged to the CHASING COVID Cohort, a national longitudinal study. Trends and correlates of vaccine hesitancy were examined longitudinally in eight interview rounds from October 2020 to July 2021. We also estimated the association between willingness to vaccinate and subsequent vaccine uptake through July 2021. Vaccine delay and refusal decreased from 51% and 8% in October 2020 to 8% and 6% in July 2021, respectively. Compared to Non-Hispanic (NH) White participants, NH Black and Hispanic participants had higher adjusted odds ratios (aOR) for both vaccine delay (aOR: 2.0 [95% CI: 1.5, 2.7] for NH Black and 1.3 [95% CI: 1.0, 1.7] for Hispanic) and vaccine refusal (aOR: 2.5 [95% CI: 1.8, 3.6] for NH Black and 1.4 [95% CI: 1.0, 2.0] for Hispanic) in June 2021. COVID-19 vaccine hesitancy was associated with lower odds of subsequent vaccine uptake (aOR: 0.15, 95% CI: 0.13, 0.18 for vaccine-delayers and aOR: 0.02; 95% CI: 0.01, 0.03 for vaccine-refusers compared to vaccine-willing participants), adjusted for sociodemographic factors and COVID-19 history. Vaccination awareness and distribution efforts should focus on vaccine delayers.
The impact of diet on wastewater treatment works phosphorus loading

ABSTRACT Phosphorus (P) is a building block for life in which the human body requires 0.55 g of per day. In some cases, this requirement is exceeded by 2 g per day, with P additives contributing to half of this exceedance. The use of P has become prominent as demand for processed convenience foods has increased. P can cause significant eutrophication once discharged to the environment. As of October 2019, 55% of assessed rivers and 73% of assessed lakes in England failed the current water quality standards. A survey was conducted to calculate the average P consumption of individuals who identify as meat eaters, flexitarians, vegetarians and vegans based on stated eating habits and reported P levels in foods, revealing an estimated P consumption of 1715, 1664, 1244, 1125 mg P/day respectively. It was estimated that current diets contribute 45% of the P load to UK wastewater treatment works (WwTW). If the UK population were to all convert to veganism this would decrease by 54% reducing the load to WwTW by over 15,000 tonnes of P per year, or 9000 tonnes of P per year if there was a move towards a 50% vegetarian or vegan population. Finally, the population needs to be better informed on what is in their food and the associated environmental impacts. GRAPHICAL ABSTRACT
Task demands moderate the effect of emotion on attentional capture

The current experiment examined the effect of task demands on attention to emotional images. Eighty participants viewed pairs of images, with each pair consisting of an emotional (negative or positive) and a neutral image, or two neutral images. Participants’ eye movements were recorded during picture viewing, and participants were either asked (1) which picture contains more colour? (colour task), (2) are the images equally pleasant? (pleasantness task), (3) which picture do you prefer? (preference task), or (4) were given no task instructions (control task). Although the results did not suggest that emotional images strongly captured attention, emotional images were looked at earlier than neutral images. Importantly, the pattern of results was dependent on the task instructions; while the preference and colour task conditions showed early attentional biases to emotional images, only positive images were looked at earlier in the pleasantness task condition, and no early attentional biases were observed in the control task. Moreover, total fixation duration was increased for positive images in the preference task condition, but not in the other task conditions. It was concluded that attention to emotional stimuli can be modified by the demands of the task during viewing. However, further research should consider additional factors, such as the cognitive load of the viewing tasks and the content of the images used.
Factors Associated With 10-Year Declines in Physical Health and Function Among Women During Midlife

Key Points Question What patient-level factors in midlife women are associated with clinically important declines in physical health and function? Findings In this cohort study among 1091 women, 206 women experienced clinically important declines in the physical component summary score of the Short Form 36. Several variables had significant associations, including low baseline health, high body mass index, less educational attainment, current smoking, and several comorbid conditions. Meaning These findings suggest that patient variables could be useful for targeting interventions for women in midlife who are likely to experience clinically important declines in health and function in later life.
Heterogeneity of Prevalence of Social Media Addiction Across Multiple Classification Schemes: Latent Profile Analysis

Background As social media is a major channel of interpersonal communication in the digital age, social media addiction has emerged as a novel mental health issue that has raised considerable concerns among researchers, health professionals, policy makers, mass media, and the general public. Objective The aim of this study is to examine the prevalence of social media addiction derived from 4 major classification schemes (strict monothetic, strict polythetic, monothetic, and polythetic), with latent profiles embedded in the empirical data adopted as the benchmark for comparison. The extent of matching between the classification of each scheme and the actual data pattern was evaluated using sensitivity and specificity analyses. The associations between social media addiction and 2 comorbid mental health conditions—depression and anxiety—were investigated. Methods A cross-sectional web-based survey was conducted, and the replicability of findings was assessed in 2 independent samples comprising 573 adults from the United Kingdom (261/573, 45.6% men; mean age 43.62 years, SD 12.24 years) and 474 adults from the United States (224/474, 47.4% men; mean age 44.67 years, SD 12.99 years). The demographic characteristics of both samples were similar to those of their respective populations. Results The prevalence estimates of social media addiction varied across the classification schemes, ranging from 1% to 15% for the UK sample and 0% to 11% for the US sample. The latent profile analysis identified 3 latent groups for both samples: low-risk, at-risk, and high-risk. The sensitivity, specificity, and negative predictive values were high (83%-100%) for all classification schemes, except for the relatively lower sensitivity (73%-74%) for the polythetic scheme. However, the polythetic scheme had high positive predictive values (88%-94%), whereas such values were low (2%-43%) for the other 3 classification schemes. The group membership yielded by the polythetic scheme was largely consistent (95%-96%) with that of the benchmark. Conclusions Among the classification schemes, the polythetic scheme is more well-balanced across all 4 indices.
Low hepatitis C virus-viremia prevalence yet continued barriers to direct-acting antiviral treatment in people living with HIV in the Netherlands

Objective: To describe hepatitis C virus (HCV)-viremia prevalence and barriers to direct-acting antiviral (DAA) treatment during unrestricted access to DAA in a nationwide cohort of people with HIV (PWH). Design: Retrospective analysis of prospectively collected data. Methods: We calculated yearly HCV-viremia prevalence as proportion of HCV RNA-positive individuals ever HCV-tested. We then included HCV-viremic individuals with ≥1 visit during the era of universal DAA-access (database lock = December 31, 2018). Based on their last visit, individuals were grouped as DAA-treated or -untreated. Variables associated with lack of DAA-treatment were assessed using targeted maximum likelihood estimation. In November 2020, physicians of DAA-untreated individuals completed a questionnaire on barriers to DAA-uptake and onward HCV-transmission risk. Results: Among 25 196 PWH, HCV-viremia decreased from 4% to 5% between 2000 and 2014 to 0.6% in 2019. Being DAA-untreated was associated with HIV-transmission route other than men who have sex with men, older age, infrequent follow-up, severe alcohol use, detectable HIV-RNA, HCV-genotype 3, and larger hospital size. With universal DAA-access, 72 of 979 HCV-viremic individuals remained DAA-untreated at their last visit. Of these, 39 were no longer in care, 27 remained DAA-untreated in care, and six initiated DAA since database lock. Most common physician-reported barriers to DAA-uptake were patient refusal (20/72, 28%) and infrequent visit attendance (19/72, 26%). Only one DAA-untreated individual in care was engaging in activities associated with onward HCV-transmission. Conclusions: Prevalence of HCV-viremic PWH is low in the Netherlands, coinciding with widespread DAA-uptake. Barriers to DAA-uptake appear mostly patient-related, while HCV-transmission seems unlikely from the few DAA-untreated in care.
Altered T lymphocyte subtypes and cytokine profiles in follicular fluid associated with diminished ovary reserve

Diminished ovarian reserve (DOR) is a daunting obstacle in in vitro fertilization (IVF) or intra cytoplasmic sperm injection (ICSI), leading to poor reproductive outcomes. We aim to characterize the T cell and cytokine profiles in follicular fluid (FF) and elucidate its contribution to the development of DOR.
$B^2$ to $B$-linear magnetoresistance due to impeded orbital motion

Strange metals exhibit a variety of anomalous magnetotransport properties, the most striking of which is a resistivity that increases linearly with magnetic field B over a broad temperature and field range. The ubiquity of this behavior across a spectrum of correlated metals – both singleand multi-band, with either dominant spin and/or charge fluctuations, of varying levels of disorder or inhomogeneity and in proximity to a quantum critical point or phase – obligates the search for a fundamental underlying principle that is independent of the specifics of any material. Strongly anisotropic (momentum-dependent) scattering can generate B-linear magnetoresistance but only at intermediate field strengths. At high enough fields, the magnetoresistance must eventually saturate. Here, we consider the ultimate limit of such anisotropy, a region or regions on the Fermi surface that impede all orbital (cyclotron) motion through them, but whose imposition can be modelled nonetheless through a modified Boltzmann theoretical treatment. Application of the proposed theorem suggests that the realization of quadratic-to-linear magnetoresistance requires the presence of a bounded sector on the Fermi surface possibly separating two distinct types of carriers. While this bounded sector may have different origins or manifestations, we expect its existence to account for the anomalous magnetotransport found in a wide range of correlated materials.
Omsk hemorrhagic fever virus is a tick‐borne encephalitis virus adapted to muskrat through host‐jumping

Omsk hemorrhagic fever was first described in the early 1940s and is a natural focal infection, spread exclusively in four regions of Western Siberia, and associated with muskrat (Ondatra zibethicus). The etiological agent of this disease is the Omsk hemorrhagic fever virus (OHFV) which is closely related to the tick‐borne encephalitis virus (TBEV), and its range entirely lies within the TBEV area. OHFV belongs to the mammalian tick‐borne flaviviruses and the ecological group of arboviruses. The problem concerning the origin of OHFV remains unresolved to date. This study analyzed all nucleotide sequences of the OHFV genome obtained in the present study and available in GenBank, including the E gene fragment and the amino acid sequences of the surface glycoprotein encoded by it. The conclusions, based on the clusteron approach, suggest that OHFV originated directly from the TBEV of the Far Eastern subtype due to the host‐jump phenomenon, that is, through a rapid change from an arthropod host, Ixodes persulcatus, to a rodent, O. zibethicus. The muskrat was introduced to Western Siberia in the second half of the 1930s. The peculiarities of the biology and ecology of the muskrat in the new habitat became the reason for the TBEV cross‐species transmission. Calculations show that host‐jumping occurred between 1931 and 1947 and accompanied a cascade of adaptive amino acid substitutions in protein E. As a result, the virus changed its transmission to contact, alimentary, and airborne routes. Based on the data obtained, OHFV would be more correctly attributed to zoonotic viruses transmitted by rodents and, accordingly, to the ecological group of roboviruses.
On Alexandrov's Surfaces with Bounded Integral Curvature

During the years 1940-1970, Alexandrov and the “Leningrad School” have investigated the geometry of singular surfaces in depth. The theory developed by this school is about topological surfaces with an intrinsic metric for which we can define a notion of curvature, which is a Radon measure. This class of surfaces has good convergence properties and is remarkably stable with respect to various geometrical constructions (gluing etc.). It includes polyhedral surfaces as well as Riemannian surfaces of class C, and both of these classes are dense families of Alexandrov’s surfaces. Any singular surface that can be reasonably thought of is an Alexandrov surface and a number of geometric properties of smooth surfaces extend and generalize to this class. The goal of this paper is to give an introduction to Alexandrov’s theory, to provide some examples and state some of the fundamental facts of the theory. We discuss the conformal viewpoint introduced by Yuri G. Reshetnyak and explain how it leads to a classification of compact Alexandrov’s surfaces. This article is an updated and translated version of the paper [54], to be included in the forthcoming book Reshetnyak’s Theory of Subharmonic Metrics edited by François Fillastre and Dmitriy Slutskiy and to be published by Springer and the Centre de recherches mathématiques (CRM) in Montréal. AMS Mathematics Subject Classification: 53.c45, 52.b70
Lazy Lagrangians with Predictions for Online Learning

We consider the general problem of online convex optimization with time-varying additive constraints in the presence of predictions for the next cost and constraint functions. A novel primal-dual algorithm is designed by combining a Follow-The-Regularized-Leader iteration with prediction-adaptive dynamic steps. The algorithm achieves $\mathcal O(T^{\frac{3-\beta}{4}})$ regret and $\mathcal O(T^{\frac{1+\beta}{2}})$ constraint violation bounds that are tunable via parameter $\beta\! \in\! [1/2,1)$ and have constant factors that shrink with the predictions quality, achieving eventually $\mathcal O(1)$ regret for perfect predictions. Our work extends the FTRL framework for this constrained OCO setting and outperforms the respective state-of-the-art greedy-based solutions, without imposing conditions on the quality of predictions, the cost functions or the geometry of constraints, beyond convexity.
Block Walsh–Hadamard Transform-based Binary Layers in Deep Neural Networks

Convolution has been the core operation of modern deep neural networks. It is well known that convolutions can be implemented in the Fourier Transform domain. In this article, we propose to use binary block Walsh–Hadamard transform (WHT) instead of the Fourier transform. We use WHT-based binary layers to replace some of the regular convolution layers in deep neural networks. We utilize both one-dimensional (1D) and 2D binary WHTs in this article. In both 1D and 2D layers, we compute the binary WHT of the input feature map and denoise the WHT domain coefficients using a nonlinearity that is obtained by combining soft-thresholding with the tanh function. After denoising, we compute the inverse WHT. We use 1D-WHT to replace the 1 × 1 convolutional layers, and 2D-WHT layers can replace the 3 × 3 convolution layers and Squeeze-and-Excite layers. 2D-WHT layers with trainable weights can be also inserted before the Global Average Pooling layers to assist the dense layers. In this way, we can reduce the number of trainable parameters significantly with a slight decrease in trainable parameters. In this article, we implement the WHT layers into MobileNet-V2, MobileNet-V3-Large, and ResNet to reduce the number of parameters significantly with negligible accuracy loss. Moreover, according to our speed test, the 2D-FWHT layer runs about 24 times as fast as the regular 3 × 3 convolution with 19.51% less RAM usage in an NVIDIA Jetson Nano experiment.
An integral Euler cycle in normally complex orbifolds and Z-valued Gromov-Witten type invariants

We define an integral Euler cycle for a vector bundle E over an effective orbifold X for which (E,X) is (stably) normally complex. The transversality is achieved by using Fukaya–Ono’s “normally polynomial perturbations” [FO97] and Brett Parker’s generalization [Par13] to “normally complex perturbations. ” Two immediate applications in symplectic topology are the definition of integer-valued genus-zero Gromov–Witten type invariants for general compact symplectic manifolds using the global Kuranishi chart constructed by Abouzaid–McLean–Smith [AMS21], and an alternative proof of the cohomological splitting theorem for Hamiltonian fibrations over S2 with integer coefficients from [AMS21].
Optimizing the Communication-Accuracy Trade-off in Federated Learning with Rate-Distortion Theory

A significant bottleneck in federated learning (FL) is the network communication cost of sending model updates from client devices to the central server. We present a comprehensive empirical study of the statistics of model updates in FL, as well as the role and benefits of various compression techniques. Motivated by these observations, we propose a novel method to reduce the average communication cost, which is near-optimal in many use cases, and outperforms Top-K, DRIVE, 3LC and QSGD on Stack Overflow next-word prediction, a realistic and challenging FL benchmark. This is achieved by examining the problem using rate-distortion theory, and proposing distortion as a reliable proxy for model accuracy. Distortion can be more effectively used for optimizing the trade-off between model performance and communication cost across clients. We demonstrate empirically that in spite of the non-i.i. d. nature of federated learning, the rate-distortion frontier is consistent across datasets, optimizers, clients and training rounds.
Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography

Purpose To establish normative data on the size, shape and vascular profile of the foveal avascular zone (FAZ) in a young, healthy, Irish population, using the Cirrus 5000 HD-OCT. Certain diseases may alter FAZ appearance. Normative databases provide normal baseline values for comparison, thus improving diagnostic ability. Methods One hundred and fifty-four subjects aged 18–35 years old were recruited. Superficial FAZ area, diameter, circularity, ganglion cell layer, central macular thickness (CMT), vascular perfusion and density were measured using the Cirrus 5000. Axial length was measured with the IOL Master and blood pressure was measured using the Omron sphygmomanometer. Results Mean FAZ area was 0.22 ± 0.07 mm2, mean CMT was 263.08 ± 18. 73μm. Both were larger in females than males (p = 0.022, p = 0.000). Mean vessel density and perfusion central were 14.11 ± 2.77 mm/mm2 and 24.70 ± 4.96% respectively. Both were lower in females (p = 0.010, p = 0.019). Vessel density and perfusion inner correlated positively with minimum ganglion cell layer plus inner plexiform layer (GCL + IPL) thickness (p = 0.001, p = 0.019). CMT correlated positively with vessel density and perfusion central (p = 0.000 for both) and negatively with FAZ area (p = 0.000). Conclusions This study provides normative data for FAZ appearance and vascularity for the first time in a young, healthy, Irish population, using the Cirrus 5000 HD-OCT. Establishing machine and population specific normative data, particularly in relation to vessel density and perfusion is paramount to the early identification of ocular disease using Optical Coherence Tomography Angiography.