Miracle-dz/UniFAR-FTUs huggingface dataset:
Systemic Therapies for HER2-Positive Advanced Breast Cancer

Simple Summary HER2-positive breast cancer is an aggressive subtype of breast cancer which used to be associated with a poor prognosis, however this has been transformed by treatment advances over the past two decades. Patients with HER2-positive breast cancer are normally treated with a combination of two or more chemotherapy drugs and targeted agents which block the HER2 receptor, followed by surgery, radiotherapy and sometimes hormonal therapies. However, if the cancer is too extensive to be removed by surgery and/or has spread to other sites in the body, it is known as HER2-positive advanced breast cancer and regrettably is normally incurable. In this situation, sequential drug treatments, aiming to control the cancer for as long as possible and maintain quality of life are advised. The anti-HER2 drug, trastuzumab, was the first targeted agent developed for HER2-positive breast cancer and remains a key component of treatment for both early, curable and advanced incurable disease. Progress including the development of new targeted agents which synergise with trastuzumab and novel antibody-drug conjugates where chemotherapy is bound to the trastuzumab allowing selective delivery to cancer cells are discussed in this review. Abstract Despite recent advances, HER2-positive advanced breast cancer (ABC) remains a largely incurable disease, with resistance to conventional anti-HER2 drugs ultimately unavoidable for all but a small minority of patients who achieve an enduring remission and possibly cure. Over the past two decades, significant advances in our understanding of the underlying molecular mechanisms of HER2-driven oncogenesis have translated into pharmaceutical advances, with the developing of increasingly sophisticated therapies directed against HER2. These include novel, more potent selective HER2 tyrosine kinase inhibitors (TKIs); new anti-HER2 antibody-drug conjugates; and dual epitope targeting antibodies, with more advanced pharmacological properties and higher affinity. With the introduction of adjuvant T-DM1 for incomplete responders to neoadjuvant therapy, fewer patients are relapsing, but for those who do relapse, disease that may be resistant to standard first- and second-line therapies requires new approaches. Furthermore, the risk of CNS relapse has not been abrogated by current (neo)adjuvant strategies; therefore, current research efforts are being directed towards this challenging site of metastatic disease. In this article, we review the currently available clinical data informing the effective management of HER2-positive breast cancer beyond standard first-line therapy with pertuzumab, trastuzumab, and taxanes, and the management of relapse in patients who have already been exposed to both these agents and T-DM1 for early breast cancer (EBC). We additionally discuss novel anti-HER2 targeted agents and combinations in clinical trials, which may be integrated into standard treatment paradigms in the future.
The morphological study of the pelvic guirdle and hind limbs of Jardina Roof rat (Rattus rattus)

The morphology of pelvic girdle and the hind limbs skeleton of Jardina roof rat were studied. The girdle has one pair of os-coxae, each os-coxae consisted of anterior-dorsal illium, posterior dorsal ischium and ventral posterior pubis. The construction of the bones is generally similar to other rodents. There were differences between the acetabulum, obturator, ischium and pubis of the jardina roof rat and African giant rat. The hind limbs are comprised of the single proximal bone, the femur and the distal paired bone, the tibia-fibula. The three trochanters of the femur were the same as other rats. The fibula was shorter than the tibia and separated proximally with a large interosseous space and fused with its distal third length to the tibia. The tarsals are the proximal bones that formed the ankle and the metatarsals are the distal bones that form the sole of the foot. The five metatarsals ended with three phalanges except the first one which has two phalanges. The fifth digit is characterized by an s-shaped phalanx.
Evaluation of the Performance Characteristics of the Lightning Imaging Sensor

The Lightning Imaging Sensor (LIS) that was on board the Tropical Rainfall Measuring Mission (TRMM) satellite captured optical emissions produced by lightning. In this work, we quantify and evaluate the LIS performance characteristics at both the pixel level of LIS events and contiguous clusters of events known as groups during a recent 2-yr period. Differences in the detection threshold among the four quadrants in the LIS pixel array produce small but meaningful differences in their optical characteristics. In particular, one LIS quadrant (Q1, X ≥ 64; Y ≥ 64) detects 15%–20% more lightning events than the others because of a lower detection threshold. Sensitivity decreases radially from the center of the LIS array to the edges because of sensor optics. The observed falloff behavior is larger on orbit than was measured during the prelaunch laboratory calibration and is likely linked to changes in cloud scattering pathlength with instrument viewing angle. Also, a two-season comparison with the U.S. National Lightning Detection Network (NLDN) has uncovered a 5–7-km north–south LIS location offset that changes sign because of periodic TRMM yaw maneuvers. LIS groups and flashes that had any temporally and spatially corresponding NLDN reports (i.e., NLDN reported the radio signals from the same group and/or from other groups in the same flash) tended to be spatially larger and last longer (only for flashes) than the overall population of groups/flashes.
Potential Anti-Toxoplasmosis Efficiency of Phoenix dactylifera Extracts Loaded on Selenium Nanoparticles

Background Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii that infects humans and many types of mammals and birds. Objective To investigate the effect of selenium nanoparticles (SeNPs) and Phoenix dactylifera (Pd) extracts loaded on SeNPs as a new agent to combat chronic T. gondii infections in murine model as an alternative method to standard Spiramycin drug therapy. Methods A total of 64 female mice were randomly divided into eight groups: GI: Normal control, GII: Positive control, GIII: infected and treated with Spiramycin, GIV: infected and treated with SeNPs, GV: infected and treated with aqueous extract of Pd, GVI: infected and treated with methanolic extract of Pd, GVII: infected and treated with aqueous extract of Pd loaded on SeNPs, GVIII: infected and treated with methanolic extract of Pd loaded on SeNPs. Date palm (P. dactylifera) fruits were identified and collected from the farms of Saudi Arabia. Preparation and characterization of SeNPs were done. The parasitological, histopathological examinations and biochemical changes were evaluated in all groups. Results Parasitological results showed significant differences in GVII in comparison to GII while GVIII showed significant differences in comparison to GII and GIII. The histopathological section of the cerebral cortex showed obvious alterations in the infected compared with untreated control groups. Aqueous and methanolic extracts of P. dactylifera loaded on SeNPs treatment showed improvement that indicated by few perivascular cuffing with few inflammatory cell infiltrations. Few granule cells with mild intracellular vacuolation and edema few deformed neurons with deep pyknotic nuclei. Microglia cells expression of Iba-1 and inflammatory cytokines (IL-4, IL-10 and INF-γ) in serum of all groups was higher in GII and lowest in GVIII followed by GVII. Conclusion SeNPs and P. dactylifera extracts loaded on SeNPs could be a potent agent to combat T. gondii infections.
Generation Z's Determinants for Using Online Food Delivery in Jakarta

One of the Indonesia's leading online food delivery services is Shopee Food. It has competed with other big players. This application has caught the attention of users, even those from the Z generation, who are known for their easy-to-move characteristics and are close to technological applications but sensitive to user experience. This generation's convenience is influenced by many factors. This study analyzes the factors that influence attitudes and behavior for sustainable use of this application in Jakarta. Quantitative data is collected using a survey and questionnaire. This PLS-SEM modeling study shows that after using the service in this application, the user's hedonic motivation must be followed by comfort and usability. The user will evaluate the post-use usefulness of the previous experience to form an attitude toward the next perceived experience. Behavioral intentions toward sustainable use are encouraged. This study highlights the importance of usability and ease of use in determining user comfort. Generation Z does not easily form positive usage attitudes until the benefits of the next experience are the same or better.
Smile esthetic

Most patients require orthodontic treatment to improve the esthetics of their smile. Orthodontists must consider how some parameters of mini-esthetics can influence the patient’s esthetic perception. Methods: A photograph of the smile of a young female was taken and some modifications were made to the buccal corridor, gingival exposure, smile arc and midline position to assess the influence of these variables on smile attractiveness. Two hundred examiners were selected from four groups: orthodontists (O), dental students (DS), orthodontic patients (OP) and surgical-orthodontic patients (SOP). Each examiner was asked to complete the questionnaire with an approval rating from 1 to 10. Significant level was set at P ≤ 0.05. Results: Only orthodontists considered buccal corridors of 4mm and midline deviation of 1mm as non-esthetic; all other examiners considered gingival exposures ≥3 mm and midline angulation as non-esthetic. All examiners assigned higher satisfaction values to the photo with the concordant smile arc and defined as non-esthetic the covered smile and the reverse smile arc. Patients perceived as non-esthetic only midline deviations of 4mm. The surgical orthodontic patients assigned lower values to the photos and showed greater attention to evaluating the esthetics of the smile than the orthodontic patients. Conclusion: Smile arc, gingival exposure and midline angulation influence smile esthetics; the role of buccal corridors and midline deviation is dependent on the type of examiner.
Checking Different Video Game Mechanics to Assess Cognitive Abilities in Groups with and without Emotional Problems

This study assesses cognitive abilities through video games for entertainment (Blek, Edge, and Unpossible) that were programmed from scratch to record players’ behavior and the levels achieved in a sample without emotional problems and in one with emotional problems. The non-emotional-problem sample was recruited from three universities and two bachelor’s degree programs. The emotional-problem sample was recruited from two outpatient centers. The participants in the emotional-problem sample completed reduced versions of the ability tests and video games, as required by their emotional problems. Three subtests of the Differential Aptitude Test that assessed abstract reasoning, visuospatial reasoning, and perceptual speed were selected as ability tests. All participants were required to complete a mental health questionnaire (PROMIS) and a brief questionnaire on their gaming habits and previous experience with the video games used. The results that were obtained showed good convergent validity of the video games as measures of cognitive abilities, and they showed that the behavior of players in the sample without emotional problems while playing predicted the level achieved in the Blek and Unpossible game fragments, but this was only true for Unpossible in the emotional-problem sample; finally, shorter versions of the Blek and Edge game fragments can be used because they maintain their good psychometric properties.
Comparative analysis of fasting effects on the cecum microbiome in three guinea pig breeds: Andina, Inti, and Peru

Guinea pigs have historically been used as a food source and are also an important model for studying the human intestines. Fasting is the act of temporarily stopping the intake of food. This process can alter the microbiota of various animals. This study is the first to investigate the impact of fasting on the cecum microbiome of three guinea pig breeds. We investigated the impact of fasting on the microbiome population structure in the cecum of three guinea pig breeds. This was done by sequencing and analyzing the V4 hypervariable region of the 16S rRNA gene in bacterial communities found in cecum mucosa samples. To achieve this, we established two treatment groups (fasting and fed), for each of the three guinea pig breeds: Andina, Inti, and Peru. The study involved twenty-eight guinea pigs, which were divided into the following groups: Andina-fed (five), Andina-fasting (five), Inti-fed (four), Inti-fasting (five), Peru-fed (five), and Peru-fasting (four). The results indicated a significant difference in beta diversity between the treatment groups for the Peru breed (P-value = 0.049), but not for the treatment groups of the Andina and Inti breeds. The dominant phyla across all groups were Firmicutes and Bacteroidetes. We observed variations in the abundance of different taxa in the cecum microbiota when comparing the treatment groups for each breed. Additionally, there was a higher number of unique taxa observed in the fasting groups compared to the fed groups. We discovered that the genus Victivallis was the only one present in all fasting groups across all breeds. Despite the findings, the resilience of the gut microbiome was not challenged in all three breeds, which can lead to disruptive changes that may affect the overall maintenance of the cecum microbiome. Based on the observed differences in the treatment groups of the Peru breed, it can be suggested that fasting has a greater impact on this particular breed.
The Effects of Digital Addiction on Brain Function and Structure of Children and Adolescents: A Scoping Review

The escalating prevalence of studies investigating digital addiction (DA) and its detrimental impact on the human brain’s structure and functionality has been noticeable in recent years. Yet, an overwhelming majority of these reviews have been predominantly geared towards samples comprising college students or adults and have only inspected a single variant of DA, such as internet gaming disorder, internet addiction disorder, problematic smartphone use, tablet overuse, and so forth. Reviews focusing on young children and adolescents (ages 0–18), or those which amalgamate various types of DA, are decidedly scarce. Given this context, summarizing the effects of DA on brain structure and functionality during the vital developmental stage (0–18 years) is of immense significance. A scoping review, complying with the PRISMA extension for such reviews, was conducted to amalgamate findings from 28 studies spanning a decade (2013–2023) and to examine the influence of assorted forms of DA on the brains of children and adolescents (0–18 years). The synthesized evidence indicated two primary results: (1) DA exerts harmful effects on the structure and functionality of the brains of children and adolescents, and (2) the prefrontal lobe is the region most consistently reported as impacted across all research. Furthermore, this review discerned a notable void of studies investigating the neural indices of digital addiction, along with a shortage of studies focusing on young children (0–6 years old) and longitudinal evidence. This research could provide the necessary theoretical basis for the thwarting and intervention of digital addiction, a measure indispensable for ensuring healthy brain development in children and adolescents.
Comprehensive approach to physical skill in different age groups in sports games

The formation of young athletes is very important and for this it is necessary to build appropriate training programs that help them grow, develop to have results in sports activities in which they participate. Methods: This literature review was conducted in accordance with the guidelines for meta- analyses of (Tricco et al. 2018), to address the research questions. To collect the data for our study, 4 bibliographic databases (PubMed, Scopus, Web of Science and Pro Quest) were used using the Jab Ref program. Results: From 105 articles in incompatibility with the concept of dexterity, speed, strength, coordination only 23 scientific articles that matched our requirements remained for our study. Conclusions: From this study some light can be shed and some recommendations can be made to guide future research efforts. Data from several studies have identified that combined training programs can be considered a safe and successful method when working with adolescents. Training and testing of athletes must be structured in specific ways. Assessments are important for coaches to identify athletes' strengths and weaknesses in order to adapt and apply the appropriate training method. Comprehensive assessments are needed to draw conclusions about the origins of changes in agility and coordination performance.
Effect of using three types of vinegar on the quality and Shelf Life of table egg

The current investigation was conducted to study the effectiveness of apple, grape and lemon vinegar coating in the shelf life of table eggs stored under room and refrigerator conditions for eight weeks. Two –hundred and forty table eggs from broiler breeder 57 weeks old were taken in the field and divided into eight treatments in two conditions, each including four treatments. T1 (control group) 60 eggs, T2 (apple vinegar) 60 eggs, T3 (lemon vinegar) 60 eggs and T4 (grape vinegar) 60 eggs were studied for eight weeks to evaluate egg quality characteristics after each two weeks and internal chemical compounds in the last week. The result showed a significant (P≤0.01) improvement of egg weight (g) in T2 and T3 in refrigerator conditions compared toT1, which recorded the lowest egg weight and decreased egg weight loss. Moreover, albumin height (mm) was increased while albumin diameter decreased, and yolk index significantly (P≤0.01) increased in refrigerator conditions. Additionally, air cells were significantly (P≤0.01) decreased in all vinegar-sprayed eggs, particularly in apple and grape treatments in both conditions. Three types of vinegar significantly (P≤0.01) improved moisture content by about 4%, and 2% in refrigerator condition. Results in this study indicate that using 5% of apple, lemon and grape vinegar solution of coating table egg extends egg-shelf life from one month to two months and more without negatively affecting the quality and quantity of eggs.
Secondary‐volatiles linked metallic iron in eucrites: The dual‐origin metals of Camel Donga

The unique occurrence of abundant (~1 vol%) near‐pure‐Fe metal in the Camel Donga eucrite is more complicated than previously believed. In addition to that component of groundmass metal, scattered within the meteorite are discrete nodules of much higher kamacite abundance. We have studied the petrology and composition of two of these nodules in the form of samples we call CD2 and CD3. The nodules are ovoids 11 (CD2) to 15 (CD3) mm across, with metal, or inferred preweathering metal, abundances of 12–17 vol% (CD2 is unfortunately quite weathered). The CD3 nodule also includes at its center a 5 mm ovoid clumping (6 vol%) of F‐apatite. Both nodules are fine‐grained, so the high Fe metal and apatite contents are clearly not flukes of inadequate sampling. The metals within the nodules are distinctly Ni‐rich (0.3–0.6 wt%) compared to the pure‐Fe (Ni generally 0.01 wt%) groundmass metals. Bulk analyses of three pieces of the CD2 nodule show that trace siderophile elements Ir, Os, and Co are commensurately enriched; Au is enriched to a lesser degree. The siderophile evidence shows the nodules did not form by in situ reduction of pyroxene FeO. Moreover, the nodules do not show features such as silica‐phase enrichment or pyroxene with reduced FeO (as constrained by FeO/MgO and especially FeO/MnO) predicted by the in situ reduction model. The oxide minerals, even in groundmass samples well away from the nodules, also show little evidence of reduction. Although the nodule boundaries are generally sharp, groundmass‐metal Ni content is anti‐correlated with distance from the CD3 nodule. We infer that the nodules represent materials that originated within impactors into the Camel Donga portion of the eucrite crust, but probably were profoundly altered during later metamorphism/metasomatism. Origin of the pure‐Fe groundmass metal remains enigmatic. In situ reduction probably played an important role, and association in the same meteorite of the Fe‐nodules is probably significant. But the fluid during alteration was probably not (as previously modeled) purely S and O, of simple heat‐driven internal derivation. We conjecture a two‐stage metasomatism, as fluids passed through Camel Donga after impact heating of volatile‐rich chondritic masses (survivors of gentle accretionary impacts) within the nearby crust. First, reduction to form troilite may have been triggered by fluids rich in S2 and CO (derived from the protonodules? ), and then in a distinct later stage, fluids were (comparatively) H2O‐rich, and thus reacted with troilite to form pure‐Fe metal along with H2S and SO2. The early eucrite crust was in places a dynamic fluid‐bearing environment that hosted complex chemical processes, including some that engendered significant diversity among metal+sulfide alterations.
Elucidating genetic diversity and variability in Chickpea (Cicer arietinum L.) using yield attribution traits

Fifty-six desi chickpea (Cicer arietinum L.) advance breeding lines were evaluated in order to explore the possibility of genetic divergence for yield and its contributing traits using Mahalanobis’s D2 Statistics and Principal Component Analysis. High estimates of heritability, genetic advance, GCV and PCV were recorded for seed yield per plant (92.2%, 12.4%, 37.1% and 38.7%), biological yield per plant (88.1%, 21.9%, 29.1% and 31.0%) and harvest index (87.3%, 25.0%, 22.7% and 24.3%). All the test genotypes were sort into five discrete clusters. Biological yield/plant (23.5%), days to maturity (17.3%), harvest index (14.6%), seed yield/plant (11.3%), total number of pods/plant (7.4%) and 100 seed weight (6.49%) were found to have highest percentage contributions to genetic diversity in the present research. The first six principal components (PC1 19.7%, PC 16.2%, PC3 11.2%, PC4 9.69%, PC5 7.2% and PC6 6.69%) could explain 70.68% of the total of the interaction variation and have Eigen value more than one. Genotypes JG 2016-1411, JG 2016-9605, JG 2017-46, ICCV 16105, ICCV 16109, ICCV 16112 and ICCV 16116 were present in more than one PCs hence contributed maximum towards yield and can be used in various breeding programmes for yield improvement.