Miracle-dz/UniFAR-FTUs huggingface dataset:
HIGHER ORDER SYMMETRIES OF REAL HYPERSURFACES IN C 3

We study nonlinear automorphisms of Levi degenerate hypersurfaces of ﬁnite multitype. By results of Kolar, Meylan, and Zaitsev in 2014, the Lie algebra of inﬁnitesimal CR automorphisms may contain a graded component consisting of nonlinear vector ﬁelds of arbitrarily high degree, which has no analog in the classical Levi nondegenerate case, or in the case of ﬁnite type hypersurfaces in C 2 . We analyze this phenomenon for hypersurfaces of ﬁnite Catlin multitype with holomorphically nondegenerate models in com- plex dimension three. The results provide a complete classiﬁcation of such manifolds. As a consequence, we show on which hypersurfaces 2-jets are not suﬃcient to determine an automorphism. The results also conﬁrm a conjecture about the origin of nonlinear automorphisms of Levi degenerate hypersurfaces, formulated by the ﬁrst author for an AIM workshop in 2010.
In vitro activity of combinations of ceftazidime-avibactam in in vitro checkerboard assays 1

17 To evaluate the in vitro effects of the combination of ceftazidime and avibactam on the MICs 18 of both compounds, checkerboard assays were performed for 81 clinical strains, including 55 19 Enterobacteriaceae strains (32 Klebsiella pneumoniae , 19 Escherichia coli , 1 Citrobacter 20 freundii and 3 Enterobacter cloacae ) and 26 strains of Pseudomonas aeruginosa, all with 21 known resistance mechanisms such as ESBLs and carbapenemases, phenotypically or 22 molecularly determined. Phenotypically ceftazidime-resistant strains (n=69) were analysed in 23 more detail. For the Enterobacteriaceae a concentration dependent effect of avibactam was 24 found for most strains with a maximum effect of avibactam at a concentration of 4 mg/L, 25 which decreased all ceftazidime MICs to ≤ 4 mg/L. Avibactam alone also showed 26 antibacterial activity (MIC 50 and MIC 90 being 8 and 16 mg/L respectively). For the 27 ceftazidime-resistant P. aeruginosa strains, considerable inhibition of β-lactamases by 28 avibactam was acquired at a concentration of 4 mg/L, which decreased all ceftazidime MICs 29 except one to ≤ 8 mg/L (the CLSI and EUCAST susceptible breakpoint). Increasing the 30 concentration of avibactam further decreased MICs, resulting in a maximum effect for most 31 strains at 8 to 16 mg/L. In summary, for most strains, tested addition of avibactam of 4 mg/L 32 restored the antibacterial activity of ceftazidime to a level comparable to wild-type strains, 33 indicating full inhibition, and strains became susceptible according to EUCAST and CLSI 34 criteria. Based on these in vitro data, avibactam is a promising inhibitor of different β- 35 lactamases including ESBLs and carbapenemases.
Does investor sentiment shift along with the calendar?

This study aims to examine the relationship between investor sentiment and the British stock market. The Seasonal Affective Disorder (SAD) is used as a mood-proxy to assess the influence of investor mood on both large-capitalization and small-capitalization indices in the UK. Daily index returns for the period of October 20 th 1997 to January 8 th 2018 are used, for both the FTSE 100 and the FTSE Small Cap. The descriptive statistics and Ordinary Least Squares regression estimates of the FTSE 100 index returns indicate no increased risk aversion in the fall and winter, and hence, no seasonal pattern is found in the returns of this index. However, the SAD effect appeared to be significantly present in the returns of the FTSE SmallCap, violating the Efficient Market Hypothesis. Thus, it can be concluded that investor sentiment has relatively more influence on small-capitalization stocks in the UK, which might be explained due to the relatively larger proportion of individual investors trading in small-capitalization stocks.
Health Professional Students’ Acceptance of Mobile Information Communication Technologies for Learning - a Study Using the Unified Theory of Acceptance and Use of Technology (UTAUT)

— The aim of this study was to examine what factors affect the acceptance behavior of mobile information communication technologies for learning by students in a MSc Occupational Therapy program in a Canadian university. The study addresses mobile and distance education, specifically, the function of mobile learning in higher education. A self-administrated paper-based survey was created by adapting scales used in previous research based on the Unified Theory of Acceptance and Use of Technology (UTAUT). Our research model was tested using the Partial Least Squares (PLS) technique. Social Influence was the strongest salient construct for behavioral intention to use mobile information communication technologies for learning, followed by performance expectancy of mobile information and communication technologies. Effort expectancy was not a salient construct for behavioral intention to use these technologies.
HYDATIDIFORM MOLE: INCIDENCE AND MANAGEMENT OUTCOMES IN A TERTIARY HOSPITAL IN ABUJA

Background: Hydatidiform mole is an abnormal pregnancy of clinical and epidemiological importance because it affects women in the reproductive age group and is potentially fatal with a lot of associated morbidities. Objectives: To determine the incidence, clinical presentation and management outcome of Hydatidiform mole in University of Abuja Teaching Hospital. Materials and Methods: It was a seven year retrospective study of hydatidiform mole managed in University of Abuja Teaching Hospital between 1 st January 2008 and 31 st 2014. Data were extracted from the ward and theatre registers as well as patients’ folders from the medical library and analyzed using descriptive statistics. Results: There were 12,204 deliveries during the study period and 37 cases of cases of hydatidiform mole giving an incidence of 0.3% (3 per 1000 deliveries). Majority of the patients were teenagers (29.4%) and most (32.3%) were primipara. The most common clinical features were amenorrhoea (94.1%) and bleeding per vaginam (88.2%). Seventeen cases (50.0%) had uteri larger than dates, while in 12 cases (35.3%) the uterine sizes were smaller than dates. Ovarian enlargement was noted in 17.6% of the cases. Complications in the form of haemorrhage occurred in 7 cases (20.6%). There were 3 cases (9.1%) of choriocarcinoma, all of whom did not present at all for follow-up and two of the three subsequently had hysterectomy due to excessive haemorrhage. Only two (6.1%) of the patients received chemotherapy. However, all patients (100%) were managed surgically using suction evacuation. there was no death from GTD during the study period. Conclusion: Hydatidiform mole is a remains an important cause of maternal morbidity in our Centre which is largely due to poor and inadequate follow-up. Better outcome is possible with good patients’ counseling for improved follow up care.
Uneven Family Geographies in England and Wales: (Non)Traditionality and Change between 2001 and 2011

This chapter uses 2001 and 2011 census data for England and Wales to explore how family formations at local authority district level have been reproduced and / or transformed during the 2000s. Using six variables drawn from Duncan and Smith’s (2002) earlier study of geographies of family formations, the chapter shows that regional patterns have become more entrenched, and divisions within England and Wales would appear to have become more intense. It is argued that some local authorities have seemingly joined ‘regional clubs’ of traditionality and non-traditionality, with the effects of urban-rural, coastal and university towns being a key factor in the differentials of family formations. These spatial differences will have major bearings on diverse demands for social welfare and public policy in England and Wales.
WENO-Wombat: Scalable Fifth-Order Constrained-Transport Magnetohydrodynamics for Astrophysical Applications

Due to increase in computing power, high-order Eulerian schemes will likely become instrumental for the simulations of turbulence and magnetic ﬁeld ampliﬁcation in astrophysical ﬂuids in the next years. We present the implementation of a ﬁfth order weighted essentially non-oscillatory scheme for constrained-transport magnetohydrodynamics into the code WOMBAT . We establish the correctness of our implementation with an extensive number tests. We ﬁnd that the ﬁfth order scheme performs as accurately as a common second order scheme at half the resolution. We argue that for a given solution quality the new scheme is more computationally efﬁcient than lower order schemes in three dimensions. We also establish the performance characteristics of the solver in the WOMBAT framework. Our implementation fully vectorizes using ﬂattened arrays in thread-local memory. It performs at about 0.6 Million zones per second per node on Intel Broadwell. We present scaling tests of the code up to 98 thousand cores on the Cray XC40 machine ’Hazel Hen’, with a sustained performance of about 5% of peak at scale.
The Hsa_circ_0091579/miR-940/TACR1 Axis Regulates the Development of Hepatocellular Carcinoma

Purpose: Circular RNAs (circRNAs) play important roles in hepatocellular carcinoma (HCC) development. The circRNA hsa_circ_0091579 ( circ_0091579 ) is dysregulated in HCC, while the mechanism of circ_0091579 in HCC development is largely unknown. Patients and Methods: Thirty paired cancer and adjacent normal tissues were harvested from HCC patients. SNU-387 and Huh7 cells were cultured in this study. circ_0091579 , microRNA-940 ( miR-940 ) and tachykinin-1 receptor ( TACR1 ) abundances were measured via quantitative reverse transcription-polymerase chain reaction or Western blot. Cell viability, migration, invasion, colony ability, cell cycle distribution and apoptosis were assessed via 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, transwell assay, colony formation assay and flow cytometry. The interaction among circ_0091579 , miR-940 and TACR1 was tested via dual-luciferase reporter analysis. The anti-HCC role of circ_0091579 knockdown in vivo was investigated using xenograft model. Results: circ_0091579 expression was enhanced in HCC tissue samples and cells. circ_0091579 silence inhibited cell viability, migration, invasion and colony formation, induced cell cycle arrest at G0/G1 phase, and promoted apoptosis in HCC cells. miR-940 was targeted via circ_0091579 and miR-940 knockdown reversed the suppressive effect of circ_0091579 silence on HCC development. miR-940 targeted TACR1 to repress HCC development. circ_0091579 could regulate TACR1 expression by mediating miR-940 . Down-regulation of circ_0091579 decreased xenograft tumor growth. Conclusion: Knockdown of circ_0091579 repressed HCC development by mediating miR-940 / TACR1 axis, indicating a new pathogenesis of HCC.
Covid-19 and Families With Parental Mental Illness: Crisis and Opportunity

The COVID-19 emergency has affected us all, but not equally. Families where parents have mental illness (PMI) are potentially at increased risk, but little is known about how they or their support services managed under lockdown/restrictions. We harnessed our existing partnerships with adult and child mental health services in the Republic of Ireland (RoI) and Northern Ireland (NI) to investigate the qualitative experiences of service users and families in coping during the first COVID-19 lockdown (March–May 2020), and how services were supporting them. Semi-structured phone/online interviews were conducted with 22 clinicians/managers (12 from RoI; 10 from NI) who provided information from their caseloads (~155 families with PMI). Sixteen family members (10 from RoI, 6 from NI) were also interviewed. Data were analysed using standard thematic analysis. Sixty percent of families reported improved mental health, primarily due to respite from daily stresses and the “normalisation” of mental distress in the general population. Approximately 30%, typically with more severe/enduring mental illness, reported additional challenges, and mental distress including: unmanageable child behaviours; fear of relapse/hospitalisation; financial difficulties; absence of child care; and a lack of routines. Service provision varied considerably across regions. The experiences within this case study highlight unique opportunities to address the multiple stresses of pre-emergency daily living. We also highlight how mental health services and governments might become more “pandemic ready” to more effectively support vulnerable families, including addressing service overload issues, optimising the use of digital technologies, and providing in-person contact and social supports where required.
Aging-induced Performance Degradation: Monitoring and Mitigation

Author(s): Ghaderi, Zana | Advisor(s): Bagherzadeh, Nader | Abstract: One of the fundamental challenges to the performance gain in advanced semiconductor technologyis aging-induced delay degradation of transistors, which consequently increases thelogic gates delays and eventually critical paths delays. Hence, designers have to add significanttime margin as guardband to the main critical path, which imposes considerableperformance degradation to the system. Temperature and stress (or usage) are the majorsources of transistor’s aging, which vary for different applications and are highly workloaddependent. This thesis covers challenges and opportunities in monitoring aging, its effectsand methods to combat the imposed performance and lifetime degradation in nanometerscales semiconductor platforms.We devise methods to monitor and mitigate aging in computing platforms ranging fromthe conventional reconfigurable architectures to the contemporary 3D network-on-chips andmany-core systems. To monitor aging-induced delay degradation on critical paths, we proposedSENSIBLE, a highly scalable aging sensor design that can help system-level designersto detect aging and react accordingly. Additionally, we proposed an application-dependantfiltering methodology to select Representative Critical Paths (RCPs) among a large pool ofcritical paths for aging monitoring in reconfigurable architectures. Furthermore, two proactivemethods are presented to mitigate aging impacts on application’s critical paths and SRAM cells in reconfigurable architectures. The former is a high-level physical planningcoupled with a reconfiguration policy and the latter is STABLE, a post-synthesis stress awareBoolean matching technique. To mitigate and monitor aging on Network on Chip(NoC) components in both 2D and 3D IC designs we proposed AROMa, which is an aging-awareadaptive routing algorithm. To this end, we devised Centralized Aging Table (CAT) toconvert transistor level aging phenomenon to the workloads’ behavior in NoC-based manycoresystems. Finally, an aging-aware task mapping, ADAMANT, is proposed to balanceaging in many-core heterogeneous architectures’ components.
Hot baths: an effective supplement to exercise in disability?

Body temperature elevations are crucial to induce increases in markers associated with the health benefits of exercise. In support, anecdotal, historical and epidemiological evidence advocates the health benefits of alternative interventions resulting in passive body temperature elevations, such as Sauna or hot water immersion (HWI) therapy. This may be particularly relevant for populations with restricted ability to be physically active. PURPOSE: Here we present findings of four studies investigating HWI in both able-bodied individuals (AB) and individuals with cervical spinal cord injury (CSCI), with a focus on its impact on inflammation and glycaemic control. METHODS: All studies employed HWI protocols that increase body temperature by 1–2°C by passively immersing participants in hot water for 1 hour. RESULTS: An acute bout of HWI increases the postprandial peak glucose concentration after immersion when compared with a control condition which does not elevate core temperature. Chronically, a two-week intervention of repeated daily HWI decreases resting blood glucose and insulin concentrations. Further, the acute inflammatory response to HWI, evidenced by elevations in interleukin-6 and interleukin-1ra, does not differ between AB and CSCI. This contrasts with the blunted inflammatory response to exercise in CSCI. CONCLUSIONS/OUTLOOK: Our experimental data show that HWI leads to beneficial glycaemic and inflammatory responses that can match, and for some markers even exceed, the responses found following exercise. Although the effect of chronic HWI therapy has yet to be confirmed in populations with disability, HWI may hence represent an attractive alternative and/or supplement to exercise for populations whose ability to be active is restricted.
Minireview Selection of the Dominant Follicle in Cattle'

On the basis of gross and histologic study of ovaries, it was proposed in 1960 that two waves of follicular activity occurred during bovine estrous cycles [1]. The two-wave hypothesis was not tested and languished for more than 20 years. Results of a histologic study in 1981 [2] were consistent with the two-wave hypothesis. However, results of a 1983 study [3], involving measurement of follicles and steroid assays of blood and follicular fluid, led to the conclusion that there were three follicular waves, and each resulted in a dominant follicle. A review of follicle turnover in cattle in 1986 [4] concluded that, rather than two or three waves, progressively larger follicles developed with rapid atresia of each until an ovulatory-sized follicle appeared. The slow progress and divergent conclusions attest to the challenge inherent in studying follicle development. A technologic breakthrough was reported in 1984 [5] and has led to clarification of the nature of bovine folliculogenesis for follicles with antral diameters of 3 mm. Transrectal ultrasonic imaging provided a means for repeated, direct, noninvasive monitoring and measuring of follicles regardless of their depth within the ovary. Profiles of mean numbers of follicles for various diameter groups were bimodal during the estrous cycle [6] and early pregnancy [7], supporting the two-wave hypothesis. The power of the technology was expanded in 1988 with reports from three laboratories [8-11] on tracking or monitoring daily diameter changes of individual follicles. One laboratory [12] found mostly (81%) two-wave estrous cycles, whereas the others [10, 11] found mostly (80%) three-wave cycles. Some of the factors found to affect the number of waves per estrous cycle include dietary intake [13], parity, and lactational status [14]. Furthermore, the diameter attained by the dominant follicle is affected by stage of the estrous cycle [12] and pregnancy [15]. Varied numbers of waves and diameters of the dominant follicle and their sensitivity to a wide array of factors are challenging aspects of this research area. In addition to clarifying the number of waves per estrous cycle, the ultrasound tracking studies have characterized the
Comment on Johnson et al , page 4253 Cyclophosphamide for CLL : to be or not CYP 2 B activated ?

In this issue of Blood, Johnson et al report their findings of the hepatic cytochrome P450 (CYP) enzyme gene polymorphisms in patients with chronic lymphocytic leukemia (CLL) treated with fludarabine and cyclophosphamide (FC) within a clinical trial. Patients with at least one *6 allele had significantly lower rates of complete response and also less toxicity than patients with *1/*1 alleles, as well as a trend of shorter progression-free survival (PFS). Albeit indirect, this is the first indication in a controlled clinical trial of a significant impact of cyclophosphamide (CPA) bioactivation in CLL and a step toward tailored therapy of cancer.
University of Birmingham Basic values predict doping likelihood

Basic values, defined as trans-situational goals that vary in importance and act as guiding principles in life (Schwartz, 1992), have been linked with unethical cognitions, emotions and actions. Their roles in doping, a form of cheating in sport, have yet to established. College athletes reported doping likelihood in hypothetical scenario-based situations and completed measures of basic values, moral disengagement, and anticipated guilt. Correlation analysis showed that doping likelihood was positively associated with self-enhancement values but negatively associated with self-transcendence values and conservation values. Moral disengagement correlated positively with self-enhancement values and negatively with self-transcendence values, whereas guilt correlated positively conservation values and negatively with self-enhancement values and openness to change values. Regression analyses showed that self-enhancement values positively predicted doping likelihood directly, self-transcendence values negatively predicted doping likelihood indirectly via moral disengagement and guilt, and conservation values negatively predicted doping likelihood indirectly via guilt. In line with theory and evidence concerning the relationship between basic value systems and moral thought and action, we found that the values of athletes are directly (self-enhancement) and indirectly (self-transcendence, conservation) linked with likely use of banned performance enhancing substances, an expression of cheating in sport. Values. short portrait values questionnaire 5, 2010) used to measure values. Participants were presented with descriptions of people and told to think about how much each person resembles them. They were asked to rate 21 descriptions (e.g., “It is important to him/her always to behave properly. He/she wants to avoid doing anything people would say is wrong” ) using a 6-point scale, anchored by 1 (not like me at all) and 6 (very much like me). The scale comprises items measuring 10 values categories: power, achievement, hedonism, stimulation, self-direction, universalism, benevolence, conformity, tradition, and security. These were combined to compute four higher-order values dimensions: self-enhancement (power, achievement, hedonism; six items), openness to change (stimulation, self-direction; four items), self-transcendence (universalism, benevolence; five items), and conservation (conformity, tradition, and security; six items). These measures have and reliability in
Arrhythmogenic Right Ventricular Cardiomyopathy/ Dysplasia

Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia (ARVC/D) is an under diagnosed idiopathic progressive cardiomyopathy, associated with mutations in genes coding for desmosomal proteins, with well-studied hereditary mechanisms in some populations. The Task Force 2010 defined diagnostic criteria for ARVC/D: structural (by echocardiography and cardiac magnetic resonance imaging); histopathological (if biopsy is required); electrical (by electrocardiography, exercise testing and Holter monitoring) and genetic/ familial. When those criteria are met, the associated sudden death risk should be then tackled by EPS, leading to the eventual insertion of an Implantable Cardioverter Defibrillator. Genetic association studies should be offered to ARVC/D patient’s offspring.