Miracle-dz/UniFAR-FTUs huggingface dataset:
Short-term e ﬀ ects of ultra ﬁ ne particles on daily mortality by primary vehicle exhaust versus secondary origin in three Spanish cities

Background: Evidence on the short-term e ﬀ ects of ultra ﬁ ne particles (with diameter < 100 nm, UFP) on health is still inconsistent. New particles in ambient urban air are the result of direct emissions and also the formation of secondary UFP from gaseous precursors. We segregated UFP into these two components and investigated their impact on daily mortality in three Spanish cities a ﬀ ected by di ﬀ erent sources of air pollution. Methods: We separated the UFP using a method based on the high correlation between black carbon (BC) and particle number concentration (N). The ﬁ rst component accounts for aerosol constituents emitted by vehicle exhaust (N1) and the second for the photochemical new particle formation enhancements (N2). We applied city-speci ﬁ c Poisson regression models, adjusting for long-term trends, temperature and population dynamics. Results: Mean BC levels were higher in Barcelona and Tenerife (1.8 and 1.2 μ g·m − 3 , respectively) than in Huelva (0.8 μ g·m − 3 ). While mean UFP concentrations were similar in the three cities, from which N1 was 40% in Barcelona, 46% in Santa Cruz de Tenerife, and 27% in Huelva. We observed an association with N1 and daily mortality in Barcelona, by increasing approximately 1.5% between lags 0 and 2, per an interquartile increase (IQR) of 3277 cm − 3 , but not with N2. A similar pattern was found in Santa Cruz de Tenerife, although none of the associations were signi ﬁ cant. Conversely, in the industrial city of Huelva mortality was associated with N2 at lag 0, by increasing 3.9% per an IQR of 12,032·cm − 3 . Conclusion: The pattern and origin of UFP determines their short-term e ﬀ ect on human health. BC is possibly the better parameter to evaluate the health e ﬀ ects of particulate vehicle exhaust emissions, although in areas in-ﬂ uenced by domestic solid fuel combustion this should also be taken into account.
Health economic assessment tools (HEAT) for walking and for cycling. Methodology and user guide. Economic assessment of transport infrastructure and policies.

The promotion of cycling and walking for everyday physical activity not only promotes health but can also have positive effects on the environment. This booklet summarizes the tools and guidance developed to facilitate this shift: the methodology for the economic assessment of transport infrastructure and policies in relation to the health effects of walking and cycling; systematic reviews of the economic and health literature; and guidance on applying the health economic assessment tools and the principles underlying it. This methodology and user guide will be of key interest to professionals at both national and local levels: transport planners, traffic engineers, and special interest groups working on transport, walking, cycling or the environment, as well as health economists, physical activity experts and health promotion experts.
Explorer A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

Epidermal homeostasis depends on a balance between stem cell renewal and terminal differentiation. The transition between the two cell states, termed commitment, is poorly understood. Here, we characterise commitment by integrating transcriptomic and proteomic data from disaggregated primary human keratinocytes held in suspension to induce differentiation. Cell detachment induces several protein phosphatases, five of which - DUSP6, PPTC7, PTPN1, PTPN13 and PPP3CA – promote differentiation by negatively regulating ERK MAPK and positively regulating AP1 transcription factors. Conversely, DUSP10 expression antagonises commitment. The phosphatases form a dynamic network of transient positive and negative interactions that change over time, with DUSP6 predominating at commitment. Boolean network modelling identifies a mandatory switch between two stable states (stem and differentiated) via an unstable (committed) state. Phosphatase expression is also spatially regulated in vivo and in vitro. We conclude that an auto-regulatory phosphatase network maintains epidermal homeostasis by controlling the onset and duration of commitment.
Cardioprotective medication use and risk factor control among US adults with unrecognized myocardial infarction: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study

Background: Individuals with unrecognized myocardial infarction (UMI) have similar risks for cardiovascular events and mortality as those with recognized myocardial infarction (RMI). The prevalence of cardioprotective medication use and blood pressure and low-density lipoprotein cholesterol control among individuals with UMI is unknown. Methods: Participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study who were recruited between May 2004 and October 2007 received baseline twelve-lead electrocardiograms (n = 21,036). Myocardial infarction (MI) status was character-ized as no MI, UMI (electrocardiogram abnormalities consistent with MI without self-reported history; n = 949; 4.5%), and RMI (self-reported history of MI; n = 1574; 7.5%). Results: For participants with no MI, UMI, and RMI, prevalence of use was 38.4%, 44.4%, and 75.7% for aspirin; 18.0%, 25.8%, and 57.2% for beta blockers; 31.7%, 38.7%, and 55.0% for angiotensin converting enzyme inhibitors or angiotensin receptor blockers; and 28.1%, 33.9%, and 64.1% for statins, respectively. Participants with RMI were 35% more likely to have low-density lipoprotein cholesterol , 100 mg/dL than participants with UMI (prevalence ratio = 1.35, 95% confidence interval 1.19–1.52). Blood pressure control ( , 140/90 mmHg) was similar between RMI and UMI groups (prevalence ratio = 1.03, 95% confidence interval 0.93–1.13). Conclusion: Although participants with UMI were somewhat more likely to use cardioprotective medications than those with no MI, they were less likely to use cardioprotective medications and to have controlled low-density lipoprotein cholesterol than participants with RMI. Increasing appropriate treatment and risk factor control among individuals with UMI may reduce risk of mortality and future cardiovascular events.
Gender and Serious Youth Victimization: Assessing the Generality Gender and Serious Youth Victimization: Assessing the Generality of Self-Control, Differential Association, and Social Bonding of Self-Control, Differential Association, and Social Bonding Theories Theories

Criminologists have long questioned whether theories that have focused on male delinquency are equally applicable to female delinquency, a phenomenon termed “gender generalizability. ” While a number of studies have used self-reports from offenders, criminologists have yet to extend this issue to crime victims. While controlling for variables derived from victimization theories, we test three criminological perspectives (self-control, differential association, and social bond) on male and female victimization using data obtained from the Evaluation of the Gang Resistance Education and Training (GREAT) Program in the United States. Results show that for male victimization, gang membership and indications of a deviant lifestyle (self-reported delinquency) significantly predicted victimization, while associating with pro-social peers and being in a gang were associated with female victimization. Parental monitoring and belong to an intact family reduced victimization for males. Self-reported delinquency consistently predicted victimization across genders.
Closer Look at the Olfactory Clefts Epithelial Adenomatoid Hamartoma: A CT Findings of Sinonasal Respiratory

BACKGROUND AND PURPOSE: Respiratory epithelial adenomatoid hamartoma is a benign glandular neoplasm of the sinonasal cavities, which presents in isolation (REAH i ) or in the setting of an adjacent inﬂammatory process such as sinonasal polyps. It is frequently found in the olfactory clefts. CT features of the 2 clinical presentations have not been well deﬁned. We present the CT ﬁndings of REAH, focusing on the degree of associated sinusitis and changes in the OCs. We hypothesized that widening of the OCs and associated severity of the sinusitis are diagnostic features of REAH, differentiating it from SNP. MATERIALS AND METHODS: In this case-control study, we compared patients with REAH i , those with REAH in the setting of SNP (REAH snp ), and those with SNP only (control patients). Patients with REAH were excluded if they had an adjacent inﬂammatory process other than SNP or if they did not have disease in the OC. We analyzed Harvard sinus CT scores and OC dimensions. RESULTS: Atotalof29patientswithREAHwereincluded:7withREAH i and22withREAH snp . Atotalof26controlpatientswereidentiﬁed. Patients with REAH i had signiﬁcantly lower Harvard CT scores than did the other groups. The OC width and the ratio of OC to the total nasal distance were signiﬁcantly larger in both REAH groups compared with those of the control patients. If the OC is 10 mm or more, the sensitivity and speciﬁcity for the presence of REAH are 88% and 74%, respectively. CONCLUSIONS: Both clinical presentations of REAH are associated with OC widening on CT scan. In the setting of polypoid disease, an OC width of (cid:1) 10 mm should increase suspicion for the presence of REAH.
Comparing the Effect of Interval and Continuous Small-Sided Games on the Bio-Motor Abilities of Young Soccer Players

Objective: This study aimed to compare the effect of interval and continuous small-sided games (SSG) training on the bio-motor abilities of young soccer players. Methods: Sixteen young soccer players (age: 19.5±0.5 years; height: 177±4.72) were ranked based on the result of a running-based anaerobic sprint test (RAST) and randomly divided into two groups; continuous SSG training (CSSG, n = 8) and interval SSG (ISSG, n = 8). The training protocols were performed for eight weeks, three sessions per week. Participants were assessed twice (pre-and post-intervention) to estimate their anaerobic capacity with the RAST, aerobic capacity with Yo-Yo intermittent recovery test, body fat percentage with a bioimpedance analysis, speed with a 30-meter run test, and agility with the Illinois agility test. During the training session, the rating of the perceived exertion (RPE) and heart rate (mean and maximum) were recorded to assess the training load. Results: In general, both aerobic and anaerobic capacities improved after ISSG (p<0.05, for all). The between-group analysis with repeated measures ANOVA revealed that there were higher values for ISSG than CSSG groups in the post-intervention in anaerobic power (p=0.042, η p2=0.264). In addition, the independent t-test results indicated that ISSG presented lower values of mean heart rate (p=0.023, effect size [ES]=0.85) and RPE (p<0.05, ES=0.88) than CSSG. Moreover, higher values for maximum heart rate were revealed for ISSG than for the CSSG group (p=0.004, ES=0.85). Conclusion: We conclude that ISSG could provide better results in the anaerobic power than CSSG.
Mindfulness-Based Stress Reduction for Head and Neck Cancer patients undergoing radiotherapy of curative intent: A descriptive pilot study

People with Head and Neck cancer (HNC) experience elevated symptom toxicity and co-morbidity as a result of treatment, which is associated with poorer psychosocial and quality-of-life outcomes (QoL). This Phase I study examined whether an individualised Mindfulness-Based Stress Reduction (IMBSR) program could be successfully used with HNC patients undergoing curative treatment. Primary aims were to explore feasibility, compliance, acceptability and fidelity. Secondary aims were to determine whether a) participation in the intervention was associated with changes in post-intervention mindfulness and, b) post-intervention mindfulness was associated with post-intervention distress and QoL. Nineteen HNC patients participated in a 7-session IMBSR program with pre and post-test outcome measures of psychological distress, depression, anxiety and QoL. Primary aims were assessed by therapists or participants. Mindfulness, distress and QoL were assessed using self-report questionnaires at pre-and post-intervention. Longer time spent meditating daily was associated with higher post-intervention mindfulness. After controlling for pre-intervention mindfulness, there was an association between higher post-intervention mindfulness and lower psychological distress and higher total, social and emotional QoL. This study offers important preliminary evidence than an IMBSR intervention can be administered to HNC patients during active cancer treatment. A randomised controlled trial is warranted to confirm these findings.
Effect of pesticide exposure on serum cholinesterase level and asthma control among children in Naivasha, Kenya

xiv 1.1 Background . 1 1.2 Statement of the research problem.3 1.3 Goal of the study.4 1.4 Objectives . 4 1.4. 1 Main objective . 4 1.4. 2 Specific objective.4 1.5 Research questions.4 1.6 Hypothesis.4 1.7 Justification of the study . 4 1.8 Significance of the study.5 1.9 Study Limitation . 5 Chapter: Literature review . 6 2.
Spatio-temporal evolution of aseismic ground deformation in the Mexicali Valley (Baja California, Mexico) from 1993 to 2010, using differential SAR interferometry

Abstract. Ground deformation in Mexicali Valley, Baja California, Mexico, the southern part of the Mexicali-Imperial valley, is influenced by active tectonics and human activity, mainly that of geothermal fluid extraction in the Cerro Prieto Geothermal Field. Significant ground deformation, mainly subsidence (~ 18 cm yr−1), and related ground fissures cause severe damage to local infrastructure. The technique of Differential Synthetic Aperture Radar Interferometry (DInSAR) has been demonstrated to be a very effective remote sensing tool for accurately measuring the spatial and temporal evolution of ground displacements over broad areas. In present study ERS-1/2 SAR and ENVISAT ASAR images acquired between 1993 and 2010 were used to perform a historical analysis of aseismic ground deformation in Mexicali Valley, in an attempt to evaluate its spatio-temporal evolution and improve the understanding of its dynamic. For this purpose, the conventional 2-pass DInSAR was used to generate interferograms which were used in stacking procedure to produce maps of annual aseismic ground deformation rates for different periods. Differential interferograms that included strong co-seismic deformation signals were not included in the stacking and analysis. The changes in the ground deformation pattern and rate were identified. The main changes occur between 2000 and 2005 and include increasing deformation rate in the recharge zone and decreasing deformation rate in the western part of the CPGF production zone. We suggested that these changes are mainly caused by production development in the Cerro Prieto Geothermal Field.
Technics as Hermeneutics

In this paper, I outline, how technics can be understood as a special case of hermeneutics. My argument hinges on the concept of practice, which, according to Joseph Rouse, is hermeneutic activity. I show how Rouse’s practical hermeneutics and Don Ihde’s material hermeneutics can be considered to be founded on the pragmatist theory of meaning. For John Dewey, interpretation is thoroughly technical.
Policy Issues vs. Documentation: Using BERTopic to Gain Insight in the Political Communication in Instagram Stories and Posts during the 2021 German Federal Election Campaign

We give first insights in the political communication of the 2021 Federal election campaign in Germany. We focused on political messages found in ephemeral stories (n=2208) and permanent posts (n=718) shared in the last fortnight of the campaign. Topic modeling with BERTopic did not yield topics as finely grained as the categories of prior content analyses, yet two main themes emerged: The majority of posts deal with policy issues, while the majority of stories does not deal with policy issues. We found a large body of stories to be documentation of the rallies and campaign trail.
Brand innovation, brand relationship, brand commitment, quality of customer interaction, and behavioral intention in hotels

Branding in the hotel industry is vital in promoting a positive guest business relationship. Branding leads to trust and loyalty and consequently to repeated purchase behavior, and it can help the organization differentiate from its competitors. This study examines the connection between brand innovation, brand relationship, brand commitment, behavioral intentions, and quality of customer interaction in the hotel industry. The results provide compelling evidence for the proposed relationships between brand innovation and the other four variables. This is the only study focusing on the effect of brand innovation on these variables in the hotel industry.
Anti-Diabetic and Anti-Lipidemic Effects of Prickly Pear Juice Enriched with Sage or Mint Leaves Powder in Alloxan-Induced Diabetic Rats

: Effect of Prickly pear juice enriched with Sage or Mint leaves powder on serum glucose, insulin levels and Lipid profile of relative control and diabetic rats was evaluated. The mean values of serum glucose level of positive control group were significantly (p< 0.05) higher than that of negative control. The mean values were 253 and 78 mg/dl, respectively. Addition of sage or mint leaves powder to Prickly pear juice caused a significant (p< 0.05) decrease in the level of serum glucose in comparing to positive control group. On the other hand, the best serum glucose result was observed in the group fed on Prickly pear juice with Sage (1.5%) is 175.3 mg/dl. The insulin level of negative control group were significantly (p< 0.05) higher than that of positive control. The mean values of insulin were 35.3 and 8.3 (µU/ml) respectively. Rats group fed on Prickly pear juice with sage 1.5% recorded the highest increase of insulin level in comparing with other treated groups. Insulin level was significantly different (p< 0.05). The mean value of insulin was 30.2 (µU/ml), while, the lowest value of insulin was recorded for Prickly pear juice being 27.3 (µU/ml). The results were significantly different (p< 0.05). The levels of total triglyceride (TG) total cholesterol (TC) in positive control groups were 171.23, 228.3 mg/dl elevated as compared with negative control group which the mean values were 102.56, 118.2 mg/dl respectively. Addition of sage or mint leaves powder to Prickly pear juice caused a reduction in serum TG, TC levels. Also, the Prickly pear juice enriched with mint or sage leaves powder (1.5%) showed higher effect in reducing the levels of TG and TC than in Prickly pear juice combined with mint or sage (1.0%). The mean value of HDL-c of positive control group (39.4 mg/dl) which showed significant (p< 0.05) decrease comparing with the negative control group (48.33 mg/dl). Meanwhile, data indicated that the consumption of Prickly pear juice enriched with Sage or Mint led to increase HDL-c. The highest increase in HDL-c was observed in diabetic group administrated with Prickly pear juice enriched with sage (1.5%) (59.01 mg/dl). The level of low-density lipoprotein LDL-c cholesterol in the positive control group was high, where the value was 154.66 mg /dl compared to the negative control group, where the mean value was 49.36 mg /dl. The obtained results indicated that mean values of VLDL-c of positive control group were higher than that of negative control with significant difference (34.24 and 20.51 mg/dl). Rats group consumed Prickly pear juice enriched with 1.5% mint leaves powder recorded the highest reduction of VLDL-c level (the mean value was 22.8 mg/dl).
Chromatographic phospholipid trapping for automated H/D 1 exchange mass spectrometry analysis of membrane protein-lipid 2 assemblies

36 Lipid interactions modulate the function, folding, structure, and organization of membrane proteins. 37 Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has emerged as a useful tool to understand 38 the structural dynamics of these proteins within lipid environments. Lipids, however, have proven 39 problematic for HDX-MS analysis of membrane-embedded proteins, due to their presence impairing 40 proteolytic digestion, causing liquid chromatography column fouling, ion suppression, and/or mass spectral 41 overlap. Here, we describe the integration of a chromatographic phospholipid trap column into the HDX-42 MS apparatus to enable online sample delipidation prior to protease digestion of deuterium labeled protein-43 lipid assemblies. We demonstrate the utility of this method on membrane scaffold protein lipid nanodisc – 44 both empty and loaded with the ~115 kDa transmembrane protein AcrB – proving efficient and automated 45 phospholipid capture with minimal D-to-H back-exchange, peptide carry-over, and with minimal protein 46 loss. Our results provide insights into the efficiency of phospholipid capture by ZrO 2 -coated and TiO 2 47 beads, and describe how solution conditions can be optimized to maximize the performance of our online, 48 but also the existing offline, delipidation workflows for HDX-MS. We envision that this HDX-MS method 49 will significantly ease membrane protein analysis, allowing to better interrogate their dynamics in artificial 50 lipid bilayers or even cell membranes. 51 52 53
Fourth Intron -Splicing Site Leading to Retention of the ' and a Suboptimal 3 in Pancreatic Carcinoma : Role of Reduced Cellular U2AF35 A Misspliced Form of the Cholecystokinin-B/Gastrin Receptor

Abnormal splicing of primary RNA transcripts of normal genes is a recognized mechanism for the production of some abnormal proteins found in cancer cells. A misspliced form of the cholecystokinin-B/gastrin (CCK-B) receptor recently was reported to be present in colon carcinoma, where it was postulated to play a role in stimulating tumor growth (M. R. Hellmich et al., J. Biol. Chem., 275: 32122–32128, 2000). Here, we report the presence of the same abnormal protein in pancreatic carcinoma and explore the molecular basis for this missplicing event. Reverse transcription-PCR and sequencing were used to demonstrate the presence of a misspliced form of the CCK-B receptor having its fourth intron retained in three pancreatic cancer cell lines and in tumor tissue, but not in surrounding healthy pancreas, from two patients with pancreatic carcinoma. A mini-gene construct representing the region of this gene from its third through its fifth exon and containing the two intervening introns was produced and transiently expressed in the MIA PaCa-2 human pancreatic cancer cell line. Specific reverse transcription-PCR reactions with both vector-derived and receptor-specific primers demonstrated the presence of both correctly fully spliced and selectively misspliced forms of this receptor. Mutagenesis of the mini-gene demonstrated that a suboptimal sequence at the 3 -end of intron 4 contributed to this missplicing. This focused attention on the U2 small nuclear ribonucleoprotein particle auxiliary splicing factors (U2AFs) known to interact specifically with this domain. Indeed, quantitative real-time PCR demonstrated a reduced level of expression of one of these factors, U2AF35, in pancreatic cancer cells compared with healthy pancreas. Furthermore, the relative amount of missplicing of the CCK-B receptor mini-gene in the pancreatic cancer cell line was reversed by transfection of the cells with U2AF35 cDNA. This work describes the presence of an additional abnormal protein in pancreatic cancer and describes a new molecular mechanism for its production, providing additional potential therapeutic targets.