Miracle-dz/UniFAR-FTUs huggingface dataset:
Phosphorylcholine Monoclonal Antibody Therapy Decreases Intraplaque Angiogenesis and Intraplaque Hemorrhage in Murine Vein Grafts

Phosphorylcholine (PC) is one of the main oxLDL epitopes playing a central role in atherosclerosis, due to its atherogenic and proinflammatory effects. PC can be cleared by natural IgM antibodies and low levels of these antibodies have been associated with human vein graft (VG) failure. Although PC antibodies are recognized for their anti-inflammatory properties, their effect on intraplaque angiogenesis (IPA) and intraplaque hemorrhage (IPH)—interdependent processes contributing to plaque rupture—are unknown. We hypothesized that new IgG phosphorylcholine antibodies (PC-mAb) could decrease vulnerable lesions in murine VGs.Therefore, hypercholesterolemic male ApoE3*Leiden mice received a (donor) caval vein interposition in the carotid artery and weekly IP injections of (5 mg/kg) PCmAb (n = 11) or vehicle (n = 12) until sacrifice at day 28. We found that PCmAb significantly decreased vein graft media (13%), intima lesion (25%), and increased lumen with 32% compared to controls. PCmAb increased collagen content (18%) and decreased macrophages presence (31%). PCmAb resulted in 23% decreased CD163+ macrophages content in vein grafts whereas CD163 expression was decreased in Hb:Hp macrophages. PCmAb significantly lowered neovessel density (34%), EC proliferation and migration with/out oxLDL stimulation. Moreover, PCmAb enhanced intraplaque angiogenic vessels maturation by increasing neovessel pericyte coverage in vivo (31%). Together, this resulted in a 62% decrease in IPH. PCmAb effectively inhibits murine atherosclerotic lesion formation in vein grafts by reducing IPA and IPH via decreased neovessel density and macrophages influx and increased neovessel maturation. PC-mAb therefore holds promise as a new therapeutic approach to prevent vein graft disease.
Study of the theta dependence of the vacuum energy density in chiral effective Lagrangian models at zero temperature

We perform a systematic study of the modifications to the QCD vacuum energy density $\epsilon_{vac}$ in the zero-temperature case ($T=0$) caused by a small, but non-zero, value of the parameter $\theta$, using different effective Lagrangian models which include the flavour-singlet meson field and implement the $U(1)$ axial anomaly of the fundamental theory. In particular, we derive the expressions for the topological susceptibility $\chi$ and for the second cumulant $c_4$ starting from the $\theta$ dependence of $\epsilon_{vac}(\theta)$ in the various models that we have considered. Moreover, we evaluate numerically our results, so as to compare them with each other, with the predictions of the Chiral Effective Lagrangian, and, finally, also with the available lattice data.
Uncertainties in polarimetric 3D reconstructions of coronal mass ejections

This work is aimed at quantifying the uncertainties in the 3D reconstruction of the location of coronal mass ejections (CMEs) obtained with the polarization ratio technique. The method takes advantage of the different distributions along the line of sight (LOS) of total (tB) and polarized (pB) brightnesses to estimate the average location of the emitting plasma. To this end, we assumed two simple electron density distributions along the LOS (a constant density and Gaussian density profiles) for a plasma blob and synthesized the expected tB and pB for different distances $z$ of the blob from the plane of the sky (POS) and different projected altitudes $\rho$. Reconstructed locations of the blob along the LOS were thus compared with the real ones, allowing a precise determination of uncertainties in the method. Independently of the analytical density profile, when the blob is centered at a small distance from the POS (i.e. for limb CMEs) the distance from the POS starts to be significantly overestimated. Polarization ratio technique provides the LOS position of the center of mass of what we call folded density distribution, given by reflecting and summing in front of the POS the fraction of density profile located behind that plane. On the other hand, when the blob is far from the POS, but with very small projected altitudes (i.e. for halo CMEs, $\rho < 1.4$ R$_\odot$), the inferred distance from that plane is significantly underestimated. Better determination of the real blob position along the LOS is given for intermediate locations, and in particular when the blob is centered at an angle of $20^\circ$ from the POS. These result have important consequences not only for future 3D reconstruction of CMEs with polarization ratio technique, but also for the design of future coronagraphs aimed at providing a continuous monitoring of halo-CMEs for space weather prediction purposes.
Interstellar Neutral Gas Species and Their Pickup Ions inside the Heliospheric Termination Shock: The Large-scale Structures

We study the distribution of the interstellar neutral (ISN) gas density and the pickup ion (PUI) density of hydrogen, helium, neon, and oxygen in the heliosphere for heliocentric distances from inside 1 au up to the solar wind termination shock (TS), both in and out of the ecliptic plane. We discuss similarities and differences in the large-scale structures of the ISN gas and PUIs formed in the heliosphere between various species. We discuss the distribution of ISN gas and PUI densities for two extreme phases of the solar activity cycle, it is the solar minimum and the solar maximum. We identify the location of the ISN gas density cavity of various species. We study the relative abundance ratios of Ne/O, H/He, Ne/He, and O/He for ISN gas and PUIs densities and their variation with location in the heliosphere. We also discuss the modulation of relative abundance ratios of ISN gas and PUIs along the TS. We conclude that the preferable locations for detection of He+ and Ne+ PUIs are in the downwind hemisphere within 1 au, whereas for H+ and O+ PUIs the preferable locations for detection are for distances from Jupiter to Pluto orbits.
FRiED: A NOVEL THREE-DIMENSIONAL MODEL OF CORONAL MASS EJECTIONS

We present a novel three-dimensional (3D) model of coronal mass ejections (CMEs) that unifies all key evolutionary aspects of CMEs and encapsulates their 3D magnetic field configuration. This fully analytic model is capable of reproducing the global geometrical shape of a CME with all major deformations taken into account, i.e., deflection, rotation, expansion, “pancaking,” front flattening, and rotational skew. Encapsulation of 3D magnetic structure allows the model to reproduce in-situ measurements of magnetic field for trajectories of spacecraft-CME encounters of any degree of complexity. As such, the model can be used single-handedly for the consistent analysis of both remote and in-situ observations of CMEs at any heliocentric distance. We demonstrate the latter by successfully applying the model for the analysis of two CMEs.
STELLAR MASS AND COLOR DEPENDENCE OF THE THREE-POINT CORRELATION FUNCTION OF GALAXIES IN THE LOCAL UNIVERSE

The three-point correlation function (3PCF) for galaxies provides an opportunity to measure the non-Gaussianity generated from nonlinear structure formation and also probes information about galaxy formation and evolution that is generally not available from the two-point correlation function (2PCF). We measure the 3PCF of the Sloan Digital Sky Survey DR7 main sample galaxies in both redshift and projected spaces on scales up to 40 h−1 Mpc. We explore the dependence of the 3PCF on galaxy stellar mass and color in order to constrain the formation and evolution for galaxies of different properties. The study of the dependence on these properties also helps better constrain the relation between galaxy stellar mass and color and the properties of their hosting dark-matter halos. We focus on the study of the reduced 3PCF, Q, defined as the ratio between the 3PCF and the sum of the products of the 2PCFs. We find a very weak stellar-mass dependence of Q in both redshift and projected spaces. On small scales, more massive galaxies tend to have slightly higher amplitudes of Q. The shape dependence of Q is also weak on these small scales, regardless of stellar mass and color. The reduced 3PCF has a strong color dependence for the low-mass galaxies, while no significant dependence on color is found for the high-mass galaxies. Low-mass red galaxies have higher amplitudes and stronger shape dependence of the reduced 3PCF than the blue galaxies, implying that these low-mass red galaxies tend to populate filamentary structures. The linear galaxy bias model fails to interpret the color dependence of Q, emphasizing the importance of a nonvanishing quadratic bias parameter in the correct modeling of the galaxy color distribution.
Application of Biocomposite Films of Chitosan/Natural Active Compounds for Shelf Life Extension of Fresh Poultry Meat

Active packaging based on chitosan (Ch) incorporated with six different natural hydro-alcoholic extracts (HAE) (rosemary, green tea, black tea, ginger, kenaf, and sage) were developed and tested to extend the shelf life of fresh poultry meat. The quality of the meat packaged was assessed through physical-chemical and microbiological characterization over 15 days of refrigerated storage. In vitro antimicrobial activity of pure extracts and films against Gram-positive (B. cereus) and Gram-negative (S. enterica) foodborne bacteria was also addressed. Pure extracts and the films developed showed antimicrobial activity by the diffusion agar method only against the Gram-positive bacteria. Microbial analysis of the meat wrapped with films incorporated with HAE showed a reduction of 3.1–4.5 log CFU/g and 2.5–4.0 log CFU/g on the total viable microorganisms and total coliforms, respectively. Ch + Kenaf and Ch + Sage films presented the highest antimicrobial activity. Regarding the oxidation degradation, as expected, TBARS values increased for all samples over time. However, the meat wrapped in the biocomposites, except for CH + Sage, presented lower secondary oxidation metabolites (reduction of 75–93%) in the content of malonaldehyde. This protection was superior for the meat wrapped with Ch + Rosemary. Active film also showed promising results by retarding the discoloration process and the increase of pH over time. Thus, the biocomposites produced can pose as an alternative technology to enhance the shelf life of fresh poultry meat and maintain its quality.
Job-Search Behaviors During Involuntary Unemployment: A Social Cognitive Approach

Job-searching following involuntary job loss is critical. However, as lifetime employment is a defining characteristic in Japan, few empirical studies have examined job-search behaviors after involuntary job loss. To fill this gap in the literature, a survey of 400 unemployed individuals explored the relationship between job-search behaviors and life satisfaction, including investigating self-efficacy, support, work volition, and dispositional optimism. Path analyses found that life satisfaction was predicted by optimism, job-search self-efficacy, and work volition, while job-search behaviors were facilitated by support and self-efficacy. No significant associations were found between job-search behaviors and life satisfaction. Results suggest that job-search interventions attempting to improve an individual’s optimism, feelings that the job search will be successful, and perceived support can facilitate job-search behaviors.
Resilience of the quantum Rabi model in circuit QED

In circuit quantum electrodynamics (circuit QED), an artificial ‘circuit atom’ can couple to a quantized microwave radiation much stronger than its real atomic counterpart. The celebrated quantum Rabi model describes the simplest interaction of a two-level system with a single-mode boson field. When the coupling is large enough, the bare multilevel structure of a realistic circuit atom cannot be ignored even if the circuit is strongly anharmonic. We explored this situation theoretically for flux (fluxonium) and charge (Cooper pair box) type multi-level circuits tuned to their respective flux/charge degeneracy points. We identified which spectral features of the quantum Rabi model survive and which are renormalized for large coupling. Despite significant renormalization of the low-energy spectrum in the fluxonium case, the key quantum Rabi feature—nearly-degenerate vacuum consisting of an atomic state entangled with a multi-photon field—appears in both types of circuits when the coupling is sufficiently large. Like in the quantum Rabi model, for very large couplings the entanglement spectrum is dominated by only two, nearly equal eigenvalues, in spite of the fact that a large number of bare atomic states are actually involved in the atom-resonator ground state. We interpret the emergence of the two-fold degeneracy of the vacuum of both circuits as an environmental suppression of flux/charge tunneling due to their dressing by virtual low-/high-impedance photons in the resonator. For flux tunneling, the dressing is nothing else than the shunting of a Josephson atom with a large capacitance of the resonator. Suppression of charge tunneling is a manifestation of the dynamical Coulomb blockade of transport in tunnel junctions connected to resistive leads.
Quantum Trajectories: Dirac, Moyal and Bohm

We recall Dirac's early proposals to develop a description of quantum phenomena in terms of a non-commutative algebra in which he suggested a way to construct what he called quantum trajectories. Generalising these ideas, we show how they are related to weak values and explore their use in the experimental construction of quantum trajectories. We discuss covering spaces which play an essential role in accounting for the wave properties of quantum particles. We briefly point out how new mathematical techniques take us beyond Hilbert space and into a deeper structure which connects with the algebras originally introduced by Born, Heisenberg and Jordan. This enables us to bring out the geometric aspects of quantum phenomena.Quanta 2019; 8: 11–23.
The Importance of Preventive Feedback: Inference from Observations of the Stellar Masses and Metallicities of Milky Way Dwarf Galaxies

Dwarf galaxies are known to have remarkably low star formation efficiency due to strong feedback. Adopting the dwarf galaxies of the Milky Way (MW) as a laboratory, we explore a flexible semi-analytic galaxy formation model to understand how the feedback processes shape the satellite galaxies of the MW. Using Markov Chain Monte Carlo, we exhaustively search a large parameter space of the model and rigorously show that the general wisdom of strong outflows as the primary feedback mechanism cannot simultaneously explain the stellar mass function and the mass–metallicity relation of the MW satellites. An extended model that assumes that a fraction of baryons is prevented from collapsing into low-mass halos in the first place can be accurately constrained to simultaneously reproduce those observations. The inference suggests that two different physical mechanisms are needed to explain the two different data sets. In particular, moderate outflows with weak halo mass dependence are needed to explain the mass–metallicity relation, and prevention of baryons falling into shallow gravitational potentials of low-mass halos (e.g., “pre-heating”) is needed to explain the low stellar mass fraction for a given subhalo mass.
WITNESSING THE FORMATION OF A BRIGHTEST CLUSTER GALAXY IN A NEARBY X-RAY CLUSTER

The central dominant galaxies in galaxy clusters constitute the most massive and luminous galaxies in the universe. Despite this, the formation of these brightest cluster galaxies (BCGs) and the impact of this on the surrounding cluster environment remain poorly understood. Here we present multiwavelength observations of the nearby poor X-ray cluster MZ 10451, in which both processes can be studied in unprecedented detail. Chandra observations of the intracluster medium (ICM) in the cluster core, which harbors two optically bright early-type galaxies in the process of merging, show that the system has retained a cool core and a central metal excess. This suggests that any merger-induced ICM heating and mixing remain modest at this stage. Tidally stripped stars seen around either galaxy likely represent an emerging intracluster light component, and the central ICM abundance enhancement may have a prominent contribution from in situ enrichment provided by these stars. The smaller of the merging galaxies shows evidence for having retained a hot gas halo, along with tentative evidence for some obscured star formation, suggesting that not all BCG major mergers at low redshift are completely dissipationless. Both galaxies are slightly offset from the peak of the ICM emission, with all three lying on an axis that roughly coincides with the large-scale elongation of the ICM. Our data are consistent with a picture in which central BCGs are built up by mergers close to the cluster core, by galaxies infalling on radial orbits aligned with the cosmological filaments feeding the cluster.
THE OPEN CLUSTER CHEMICAL ANALYSIS AND MAPPING SURVEY: LOCAL GALACTIC METALLICITY GRADIENT WITH APOGEE USING SDSS DR10

The Open Cluster Chemical Analysis and Mapping (OCCAM) survey aims to produce a comprehensive, uniform, infrared-based data set for hundreds of open clusters, and constrain key Galactic dynamical and chemical parameters from this sample. This first contribution from the OCCAM survey presents analysis of 141 members stars in 28 open clusters with high-resolution metallicities derived from a large uniform sample collected as part of the Sloan Digital Sky Survey III/Apache Point Observatory Galactic Evolution Experiment. This sample includes the first high-resolution metallicity measurements for 22 open clusters. With this largest ever uniformly observed sample of open cluster stars we investigate the Galactic disk gradients of both [M/H] and [α/M]. We find basically no gradient in [α/M] across 7.9 kpc ⩽ RGC ⩽ 14.5 kpc, but [M/H] does show a gradient for RGC < 10 kpc and a significant flattening beyond RGC = 10 kpc. In particular, whereas fitting a single linear trend yields an [M/H] gradient of −0.09 ± 0.03 dex kpc−1—similar to previously measure gradients inside 13 kpc—by independently fitting inside and outside 10 kpc separately we find a significantly steeper gradient near the Sun (7.9 ⩽ RGC ⩽ 10) than previously found (−0.20 ± 0.08 dex kpc−1) and a nearly flat trend beyond 10 kpc (−0.02 ± 0.09 dex kpc−1).
The MUSE-Wide survey : detection of a clustering signal from Lyman α emitters in the range 3 < z < 6

We present a clustering analysis of a sample of 238 Ly{$\alpha$}-emitters at redshift 3<z<6 from the MUSE-Wide survey. This survey mosaics extragalactic legacy fields with 1h MUSE pointings to detect statistically relevant samples of emission line galaxies. We analysed the first year observations from MUSE-Wide making use of the clustering signal in the line-of-sight direction. This method relies on comparing pair-counts at close redshifts for a fixed transverse distance and thus exploits the full potential of the redshift range covered by our sample. A clear clustering signal with a correlation length of r0 = 2.9(+1.0/-1.1) Mpc (comoving) is detected. Whilst this result is based on only about a quarter of the full survey size, it already shows the immense potential of MUSE for efficiently observing and studying the clustering of Ly{$\alpha$}-emitters.
Production of pronoun gender by children acquiring Russian as a minority language: comparison with the effects of developmental language disorder

This paper studies the acquisition of Russian pronominal gender by Dutch-Russian simultaneous bilinguals (4;3-7;11) growing up in the Netherlands. The performance of the bilingual group is compared to that of age-matched monolinguals with and without developmental language disorder (DLD). We hypothesize that reduced exposure toRussian in the minority-language context may lead to delays in language development, comparable to problems attested in DLD (in this case due to reduced intake). The results of a narrative elicitation task demonstrate that both monolingual groups performed at ceiling from age 4 onwards. Monolingual children with DLD were as accurate at using pronominal gender as their unimpaired peers fromthe earliest ages studied, which supports the processing accounts of DLD taking morphological richness of the target language into account. In contrast, 4-year-old bilinguals performed around chance level. The performance of the bilingual group improved with age and reached the monolingual level only by age 7. The results suggest that reduced input has more impact on theacquisition of gender in a morphologically rich language, whereas the possible effects of DLD are no longer visible after age 3.
Anyon optics with time-of-flight two-particle interference of double-well-trapped interacting ultracold atoms

The subject matter of bianyon interference with ultracold atoms is introduced through theoretical investigations pertaining to the second-order momentum correlation maps of two anyons (built upon spinless and spin-1/2 bosonic, as well as spin-1/2 fermionic, ultracold atoms) trapped in a double-well optical trap. The two-particle system is modeled according to the recently proposed protocols for emulating an anyonic Hubbard Hamiltonian in ultracold-atom one-dimensional lattices. Because the second-order momentum correlations are mirrored in the time-of-flight spectra in space, our findings provide impetus for time-of-flight experimental protocols for detecting anyonic statistics via interferometry measurements of massive particles that broaden the scope of the biphoton double-slit interferometry of quantum optics.
Type D Personality and Health Behaviors in People Living with Obesity

Background: Considering that health behaviors and personality traits play an important role in the formation of health attitudes, the main objective of this study was to evaluate the relations that occur between type D personality and health behaviors in a group of obese patients. Methods: 443 adult patients with BMI ≥ 30 kg/m2, who had been hospitalized in selected hospital facilities in the Silesian Voivodeship (Poland), participated in the study. Respondents completed three standardized questionnaires—the Multidimensional Health Locus of Control Scale, version A (MHLC-A), the Inventory of Health Behaviors (IZZ), and the Type D Scale (DS-14). Results: Patients with type D personality were characterized by the least effective mental attitudes and preventive behaviors, and differed significantly from the other personality types (intermediate and non-type D). Type D personality increased the risk of initiating improper health behaviors by more than five times. Regarding the sense of health control, patients with type D personality had significantly lower scores for the Internal Dimension subscale (21.3 ± 3.1) and higher for the Powerful Others Dimension subscale (24.0 ± 2.6), compared to patients with intermediate and non-type D personality. Proper health behaviors correlated with an internal sense of health control; the strongest correlation, defined as a medium, was with Preventive Behaviors (R = 0.42; p < 0.0001). Conclusions: Type D personality was associated with poorer attitudes towards health. Among obese respondents with a type D personality, there was a significantly higher prevalence of those who believed that their health status was a consequence of chance events.