Miracle-dz/UniFAR-FTUs huggingface dataset:
Folic acid alleviates oxidative stress in thyroxine- induced spleen injury in hyperthyroid rat

Objective: Thyroid hormones are involved in the regulation of basal metabolic state and in oxidative metabolism. This study evaluated some biochemical alterations in post-pubertal hyperthyroidism. Additionally, the ameliorating role of folic acid supplementation was investigated. Methods: A total 60 male albino rats were equally divided into six groups; the first and second groups were the control and folic acid groups respectively while the 3 group was the hyperthyroid rat group; the 4 and 5 groups were coand post treated hyperthyroid rat with folic acid respectively and the 6 group was self treated hyperthyroid rat group. Results: Serum T3 & T4 levels were a significant increase while TSH levels were a significant decrease in rats receiving thyroxine indicating the induction of hyperthyroid state. Serum cholesterol, triglycerides, HDL and LDL levels (lipid profile) were a significant decrease in hyperthyroid rats when compared with control group. On the other hand; MDA, catalase and nitric oxide levels in spleen tissues were a significant increase in hyperthyroid rats when compare with control group, while glutathione and total protein levels were a significant decrease in hyperthyroid rats when compared with control group. Treatment of hyperthyroid with folic acid were improved this alterations. Conclusions: Our results revealed that, folic acid as a treatment was better if it is administered as an adjuvant after returning to the euthyroid state.
Int. J. Biosci

Selections of desirable traits and exploration and utilization of genetic diversity have always been used as an essential tool in plant breeding. The present study was an attempt to investigate general and specific determinants of phenotypic variation among a data set of seedling characters and genotypes efficiency for a transplanting seedling. For this purpose 48 advance genotypes with three control cultivars Basmati-385, JP5 and Kangnai29 were grown in a replicated field trail and evaluated for 16 traits that were reported earlier as contributing traits of seedling vigor. ANOVA showed high CV% for SRFW, SRDW, WC, SSFW, SSDW, SFW, SDW, while lowest was found for SH followed by SLL. PCA extracted two components with 66.75% of variability. The PC1 comprised of SFW, SDW, SSFW, SSDW, SRFW, SRDW, WC as positive meaningful loading while one DG as negative one with overall 38.69% of variability. The PC2 carried 5 significant loadings i.e. SVI, SH, SLL, SLW and SLA with 28.068% of variation. The meaningful traits of PC1 and PC2 were the sub-derived variables of SH and SFW respectively. These findings pave a criterion for selection which will enable one to choose a best genotype at seedling that withstands lodging and having the ability to carry large and heavy panicle at adult stage. Apart from these, the less variability for SH and high variation in SFW indicated the capability of elite lines. The elite lines 97-m, 111-m, 161-s, Abbasi2, 105-m, 86-L, 29-s, 136-L, 158-2-L, 130-s, 14-L, 10-s, 127-m, 26L, 179-s, 19-L, 79-L, 184-s, 07-m, 17-L, 109-L, 186-m, 12-L, 52-L, M2, 69-m and 96-m were more vigorous and withstand disease attack due to its high seedling biomass and short stature that one could effectively use in further improvement of rice. * Corresponding Author: Fida Muhammad Abbasi  drfidaabbasi6@gmail.com International Journal of Biosciences | IJB | ISSN: 2220-6655 (Print) 2222-5234 (Online) http://www.innspub. net Vol. 5, No. 9, p. 197-205, 2014
Effect of L-Carnitine on Endothelial Dysfunction markers in Diabetic-Irradiated rats

Dimethylarginine (ADMA), endothelin-1(ET-1) and total nitrate/nitrite (NO(x)) are mediators of endothelial dysfunction and involved in the pathogenesis of cardiovascular diseases. Diabetes and γ-irradiation (IRR) exposure are associated with the development of various cardiovascular diseases. Oxidative stress plays a major role in the pathogenesis of diabetes mellitus leading to various complications including endothelial dysfunction. The present study was designed to evaluate the effect of L-carnitine (L-car) on ADMA, endothelin-1 and NO(x) in diabetic-γ-irradiated (STZ-IRR)rat and evaluate the anti-hyperglycemic properties of L-carnitine on streptozotocin (STZ)-induced diabetes. Serum lipid profiles, glucose level, ADMA, ET-1 and NO(x) were determined. The cellular changes were estimated using malondialdehyde (MDA) as indicies of lipid peroxidation, the antioxidants superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and reduced glutathione (GSH) and NO(x). Circulatory lipid profiles, ADMA, endothelin-1 and cardiac MDA were increased significantly, whereas the level of serum NO(x) and cardiac GSH and antioxidant enzymes were significantly decreased in IRR (5 Gy), STZ and STZ-IRRrats. Treatment with L-carnitine (200 mg/kg, i.p., every other day) for 28 days, resulted in a significant decrease in the levels of blood glucose and lipid profiles along with a significant decrease in the levels of serum ADMA,endothelin-1 and cardiac MDA. The cardiac antioxidant enzymes and GSH were increased significantly along with the serum NO(x). In conclusion, ADMA, endothelin-1 and NO(x) were implicated in endothelial dysfunction of rats exposed to STZ and/or gamma-radiation.L-carnitineoffers promising radioprotective and antidiabetic effects that may be mainly attributed to its potent antioxidant. © 2013 Universal Research Publications. All rights reserved.
The Role of Trust in the Adoption of Mobile Commerce : Comparison to the Adoption of E-Commerce

Understanding users’ acceptance of the Internet, and particularly, their intentions to use Internet commerce and mobile commerce are important in explaining how these areas of commerce have grown exponentially in recent years. This paper studies new technology factors to better understand and manage electronic commerce activities. The proposed theoretical model explains factors as they relate to the technology acceptance model, suggests that trust and other factors are related, and reveals the importance of the hedonic factor. The study’s results imply that methods of stimulating and facilitating customer participation in mobile commerce should be differentiated from those of Internet commerce.
Knowledge Indices of Rural Farm Women with Reference to Organic Farming and Organic Foods

Organic agriculture follows the principles and logic of a living organism, in which all elements (soil, plant, farm animals, insects, the farmer and local conditions) are closely linked to each other. Organic agriculture shares many techniques used by other sustainable agricultural approaches (e.g. intercropping, crop rotation, mulching, integration of crops and livestock). However, the use of natural inputs (nonsynthetic), the improvement of soil structure and fertility and the use of a crop rotation plan represent the basic rules that make organic agriculture a unique agricultural management system (Nandish, 2006).
The Etiology and Pathogenesis of Periodontal Disease

The understanding of the etiology and pathogenesis of periodontal disease has changed significantly in the last five decades, not only with regards to the specific microorganisms associated with the onset and progression of the disease, but also the dramatically elevated emphasis on the primary role of the host response in the destruction of the periodontal tissues. In this regard, Van Dyke (2014) recently highlighted the concept that the host-response in periodontal disease may not only be induced by (or follow) the microbiological insult to the gingival/periodontal tissues (traditional view), but may also precede, or result in, the development of a recognizable pathogenic microbial biofilm; this concept addresses the recent controversy as to whether chronic periodontitis should be categorized as an “infectious” disease (traditional view) or, that chronic periodontitis is an “inflammatory” disease [1].
Clinical Profile and Complications of Plasmodium Vivax Malaria

Plasmodium vivax is geographically most widely distributed with upto 2.5 billion people at risk and an estimated 70-80 million cases every year (3) . Although Plasmodium vivax malaria has a huge burden on the health, longevity and general prosperity of the people, research on Vivax malaria and its complications are grossly overlooked and left in the shadow of the enormous problem caused by Plasmodium falciparum (3) . P. vivax can cause both sequestration related and non-sequestration related complications of severe malaria as defined by WHO, including cerebral malaria, renal failure, circulatory collapse, severe anemia, haemoglobinuria, abnormal bleeding, acute respiratory distress syndrome (ARDS), jaundice, and acidosis. (3) Many studies have shown that complications associated with Plasmodium vivax are on the rise and outcomes are similar to that of Plasmodium falciparum malaria (4) . Therefore we had conducted this study in order to evaluate the complications of Plasmodium vivax malaria would help gather information on the morbidity caused by the disease and help reduce the burden and unexpected mortality due to the disease.
The costs of routine eptifibatide use in acute coronary syndromes in Western Europe : an economic substudy of the PURSUIT trial

Alms To compare resource consumption and medical costs between patients with unstable angina and non-Q wave myocardial infarction randomized to eptifibatide or placebo in the Western European arm of the PURSUIT (Platelet GP IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy) Trial. Methods and Results The PURSUIT trial collected medical resource consumption data for enrolled patients. Analyses of resources consumed were conducted for the 3697 patients recruited in Western Europe and for subgroups with different coronary arteriography rates. Unit costs were developed for six Western European countries using consistent bottom-up costing methods. These costs were applied to the resource consumption to estimate the medical treatment costs for patients assigned eptifibatide or placebo. Resource consumption varied across the six countries with a trend for lower rates of coronary arteriography and myocardial revascularization amongst eptifibatide patients. The mean costs of the initial hospital admission, including 526 EUROs for eptifibatide treatment, were 1.1% to 6.8% higher than placebo. The incremental costs associated with eptifibatide patients enrolled in the low and medium coronary arteriography rate countries were lower than those observed in high coronary arteriography rate countries. Conclusions In this analysis of the Western European subgroup of PURSUIT patients, resource consumption during the index hospital admission was consistently lower amongst eptifibatide-treated patients than amongst placebo-treated patients. Including an assumed cost of 526 EUROs for eptifibatide, the incremental cost of routine eptifibatide use was relatively modest, ranging from 122 EUROs to 425 EUROs per patient. Subgroup analyses suggest that in settings in which the use of coronary arteriography is discretionary, routine use of eptifibatide may reduce the requirement for invasive procedures and the overall economic costs of treatment.
Photoreceptors Gene Transfer by a Lentivirus Vector during a Transitory Interruption of the External Limiting Membrane in Mice

Many previous studies have concluded that the transduction of photoreceptors by LentiVirus (pseudotype or promoter used) remains suboptimal in adult experimental subjects [1]. Therefore, the efficiency of the transduction depends on the age of the subject and the degree of retinal degeneration related to the integrity of the external limiting membrane, real physical barrier to the passage of the lentivirus due probably to his large size. Recent studies have shown the use of siRNA targeting the ZO-1 protein and 5’-sequence mRNA, allowing a transient interruption of outer limiting membrane increased photoreceptor transplantation, by retaining the integrity of the retina [2]. In fact, siRNA could be taken into account in the sphere of gene therapy to optimize lentivirus transduction. Thus, further studies with a large sample size of animals are expected for a better understanding of the protocol. Our result suggests that both age and degree of photoreceptors degeneration are important parameters to consider when designing gene therapy experiments or protocols.
EFFECT OF EAR PLUGS & EYE MASK ON SLEEP AMONG ICU PATIENTS: A RANDOMIZED

Background: masks and randomized control trial aims to pattern among critically Method: patients were selected by convenience sampling and were randomized to control and experimental group using parallel group design. The perception of patient’s sleep plugs and eye mask was evaluated Using Verran and Snyder that include three main sleep sub scales: disturbance, effectiveness, and supplementation. Results: and control group as per sleep fragmentation (14.6±3.44 vs 4.19±3.58), sleep latency (6.05±1.88 vs 1.70±1.66), sleep quality (10.5±2.52 vs 2.14±2.29), sleep length (8.95±2.47 vs 2.36±2.46), sleep supplementation (11.8±3.26 vs 4.10±2.33). Conclusion: the quality of sleep among critically ill patients at all three subscales (disturbance, effectiveness, and supplem
Effect of Different Nitrogen Fertilizer Levels, and Wheat Cultivars on Yield and its Components under Sprinkler Irrigation System Management in Sandy Soil

The current research work was conducted at the Research and Production Station of National Research Center, El-Noubaria, El-Buhaira Governorate, during the two successive seasons under sprinkler irrigation system to study the response of four wheat varieties: Misr 1, Misr 2, and Sids 12 cultivars, two riser height sprinklers 1.00 and 0.75 m and different nitrogen fertilizer levels (75, 100, 125 kg/fed) on yield, yield components and water productivity with sandy soil conditions. It aimed to evaluate the effect of different nitrogen fertilizer levels and different varieties on yield, yield components of wheat as a flour source for human nutrition. The experiment design was factorial in complete randomized blocks with three replications. The results could be summarized as follows: according to the main effects under study, means values of data obtained could be ranked in the following ascending orders 75 < 100 < 125, 0.75 < 1.0 and Sids 12 < Misr 2 < Misr 1. Regarding sprinkler riser height, the increase percent by using 1.00 m were (2.7; 3.3) relative to 0.75 m in 1 st and 2 nd season. For Nitrogen levels, the increase percent under 125 kg/fed level were (2.3; 5.3) relative to 75 kg/fed level in 1 st and 2 nd season. According Egyptian wheat varieties, the increase percent with Misr 1 were (14.5; 16.3) relative to Sids 12 variety in 1 st and 2 nd season, respectively. All obtained data had significant differences at 5 % level exception little cases. It could be concluded that: although 125 kg N/fed treatment gave the highest values, using 100 or 75 kg N/fed with a variety of Misr 1 and Misr 2 for best water productivity, grain yield production and its component’s purpose, while for better flour we can recommend that using nitrogen level 120 kg N/fed, sprinkler riser height 1.00 m and variety of Misr 1.
Detecting adverse events in dietary supplement research: Lessons from ephedra alkaloids

DETECTING ADVERSE EVENTS IN DIETARY SUPPLEMENT RESEARCH: LESSONS FROM EPHEDRA ALKALOIDS. Persky AM, Rawson ES . JEPonline. 2004;7(4):84-99. In some countries, dietary supplements can be marketed with claims of efficacy or safety without any clinical trial support. As such, there is public concern whether these products are safe for use by the general population. Guidelines established by the United States Food and Drug Administration and the international pharmaceutical industry can be used to provide safety information within the umbrella term of dietary supplements. A dietary supplement would be clinically useful if the therapeutic benefits outweighed the side effects. Unfortunately, the side effects or adverse events associated with dietary supplement use are not well documented. Lack of statistical power and proper study design are the main reasons studies are unable to detect and determine the frequency of the adverse events associated with supplements. However, when adverse events are detected, the causality between the adverse events and the supplement can be diluted by factors such as underlying disease, the irregularity of product purity and uncertainty of how the subjects’ exposure to the supplement is related to potential adverse events. As such, studies intending to detect adverse events need to carefully select the study population, document concomitant disease and medications, test product purity and determine the subjects’ exposure to the supplement via blood sampling.
Citation: Vengala N. Antihyperlipidemic Activity of Flax Lignan Concentrate in Nicotinamide-Streptozotocin Induced Diabetic Hyperlipidemia

Background: Flax seeds have been shown to have multiple benefits in cardiovascular disorders. Objective: To evaluate Antihyperlipidemic activity of methanolic fraction of flax lignan concentrate (MF-FLC) obtained from Linum usitatissium L. , Linaceae in nicotinamide-STZ induced diabetic hyperlipidemia rats. Methods: Male Wistar rats were used for the study. The IAEC of Poona college of Pharmacy approved the proposal. Protocol no. CPCSEA/01/14. Diabetes was induced in rats by nicotinamide-STZ. Diabetic animals were divided into five groups: Diabetic atherosclerosis control, Atorvastatin (10 mg/kg), MF-FLC (200 mg/kg), MF-FLC (400 mg/kg), and MF-FLC (800 mg/kg). After the confirmation of diabetes, rats were treated with cholesterol (4% w/w) and cholic acid (1% w/w) for 45 days. After 15 days of cholesterol treatment, atorvastatin and MF-FLC treatment was given to respective groups for 30 days. Non-diabetic atherosclerosis group received cholesterol-cholic acid treatment alone. The control group was given coconut oil as vehicle. Results: Treatment of MF-FLC (400 mg/kg) and atorvastatin (10 mg/kg) significantly reduced systolic blood pressure (p<0.01), diastolic blood pressure (p<0.01), mean arterial blood pressure (p<0.001) and left ventricular end diastolic pressure (p<0.001) whereas there was significant increase in Max dp/dt (p<0.001) and Min dp/dt (p<0.01) indicating the effect on cardiac contractility. These findings were confirmed in histopathology. MF-FLC (400 mg/kg) showed significant (p<0.01) reduction in the glucose level. MF-FLC (400 mg/kg) was found to be effective, increase in the dose (800 mg/kg) there showed a ceiling effect. Conclusion: The treatment with MF-FLC showed significant increase in the both max and min dp/dt. Atorvastatin (10 mg/kg) also showed significant increase in the both max and min dp/dt. This suggests that MF-FLC provides sufficient contractile reserve to ameliorate the detrimental effects of diabetes on cardiac contractility. MF-FLC had additional benefit of anti-hyperglycemic effect when compared to atorvastatin.
The Effect of Non-Surgical Periodontal Treatment on Metabolic Control among Uncontrolled Type 2 Diabetic Patients

1PhD in Immunology, Department of Health 1, Southwest State University, Bahia, Brazil 2PhD in Immunology, Institute of Health, Federal University of Bahia, Bahia, Brazil 3PhD in Periodontics, Department of Health, Feira de Santana State University, Bahia, Brazil 4Master in Odontology, Department of health, Ruy Barbosa Faculty, Bahia, Brazil 5PhD in Immunology, Department of Health, Feira de Santana State University, Bahia, Brazil
Review on Factors Affecting the Nutritional Status of Women in Ethiopia

Adequate nutritional status of women is important for good health and increased work capacity of women as well as for the health of their children. However under nutrition and poor health adversely affect the well-being of millions of people in the developing world. More than 3.5 million women and children less than five aged in developing countries died each year due to the underlying cause of under nutrition. The purpose of this article is to review the factors affecting the nutritional status of women in Ethiopia. Women are mostly venerable to malnutrion because of the intake of unbalanced foods due to low economic status, low education background, marital status and age. Women of the reproductive age are amongst the most vulnerable to malnutrition. Additionally place of women residence was one factor contributing to the nutritional variation between rural and urban women. There has been a variation between married and unmarried women in their nutritional status. The unmarried and divorced women had relatively high malnutrition problem than married one. However, this argument in the economic status of women is different. Whether the women have got married or unmarried, the economic status could be the cause of malnutrition if they are coming from low economic family. Therefore in order to have the women better understanding about nutritional status, they should be encouraged to attend nutrition education.
Effect of Feeding Total Mixed Ration on Methane Emission and Energy Metabolism in Crossbred Cattle and Buffaloes

This study evaluates the nutrients digestibility and energy metabolism of crossbred cattle and buffaloes fed different ratio of concentrate and roughage based ration. 12 adult animals were used of three groups of cattle and buffalo, the following: cattle (Bos taurus × Bos indicus) (n=6) and buffalo (Bubalus bubalis) (n=6). Three groups of animals, each consisting two crossbred cattle, and two buffalo were fed experimental diets and used in 3×3 switchover design. A metabolism trial was conducted with six crossbred cattle and six buffaloes fed with different ratio of concentrate and roughage. There was non-significant difference in nutrient digestibilities between cattle and buffaloes. Respiration calorimetric studies revealed that heat production was significantly (P<0.01) lower in buffaloes however, methane emission and net energy utilization was significantly (P<0.05) higher in buffaloes than cattle. It was concluded that under higher plane of nutrition and higher concentrate: roughage ratio there is significant reduction in methane emission compared to lower plane of nutrition in both species. However, efficiency of energy utilization was significantly lower in crossbred cattle than buffaloes.
INTERACTIVE EFFECT OF SALINITY AND ASCORBIC ACID ON BRASSICA RAPA L. PLANTS

Excessive soil salinity is a major factor resulting in the low productivity of cultivated crops. Salinity causes oxidative stress in plants by enhancing production of reactive oxygen species. Ascorbic Acid is an efficient antioxidant which is essential for tolerance. However, Antioxidant responses of plants to salinity vary considerably in Brassica Rapa L. plant. The present study was conducted to investigate the effects of Ascorbic acid on Brassica Rapa L. growing under saline conditions. Different concentrations of Ascorbic acid were applied (50 mM, 100 mM). Salt toxicity significantly reduced growth of Brassica Rapa L. plants. Significant decrease in root, shoot length, protein content and antioxidant enzyme wasalleviated by the application of Ascorbic acid. Among the concentrations, 100 mM was more effective in reducing the salinity stress. Thus, it can be concluded that Ascorbic acid ameliorated the effect of salinity.