Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Curcumin on Attenuation of Liver Cirrhosis via Genes/Proteins and Pathways: A System Pharmacology Study

Background: Liver cirrhosis is a life-threatening seqsuel of many chronic liver disorders of varying etiologies. In this study, we investigated protein targets of curcumin in liver cirrhosis based on a bioinformatics approach. Methods: Gene/protein associations with curcumin and liver cirrhosis were probed in drug–gene and gene–diseases databases including STITCH/DGIdb/DisGeNET/OMIM/DISEASES/CTD/Pharos and SwissTargetPrediction. Critical clustering groups (MCODE), hub candidates and critical hub genes in liver cirrhosis were identified, and connections between curcumin and liver cirrhosis-related genes were analyzed via Venn diagram. Interaction of hub genes with curcumin by molecular docking using PyRx-virtual screening tools was performed. Results: MCODE analysis indicated three MCODEs; the cluster (MCODE 1) comprised 79 nodes and 881 edges (score: 22.59). Curcumin database interactions recognized 318 protein targets. Liver cirrhosis genes and curcumin protein targets analysis demonstrated 96 shared proteins, suggesting that curcumin may influence 20 candidate and 13 hub genes, covering 81% of liver cirrhosis critical genes and proteins. Thirteen shared proteins affected oxidative stress regulation, RNA, telomerase activity, cell proliferation, and cell death. Molecular docking analysis showed the affinity of curcumin binding hub genes (Binding affinity: ΔG < −4.9 kcal/mol). Conclusions: Curcumin impacted on several critical liver cirrhosis genes mainly involved in extracellular matrix communication, focal adhesion, and the response to oxidative stress.
Boundary determination for an inverse problem in elastodynamics

We consider the unique determination of material properties of an inhomogeneous, isotropic, elastic object from measurements made at the surface. The behavior of the 3-dimensional object is modeled by solutions of the hear. hyperbolic system of equations for elastodynamics. The material properties of the object (its density and elastic properties) correspond to the (leading) coefficients of these diffrential equations. Modeling surface measurements by the Dirichlet-to-Neumann map on a finite time interval, we show here that the Dirichlet-to-Neumann map uniquely determines the density and elastic properties of the surface of the object. Solution of this problem leads to a proof in [R] of unique determination of certain properties(the wave speeds) of the interior of the object. Techniques used here include geometric optics. propagation of singularities for systems of real principal type, and Hamilton-Jacobi theory.
Blood Reference Intervals for Antillean Manatees (Trichechus manatus manatus) from Puerto Rico

Antillean manatees (Trichechus manatus manatus) are endangered throughout the southwestern Gulf of Mexico, the Caribbean coast of Central and South America, the Greater Antilles, and the northeastern coast of South America to Brazil. Establishing blood reference intervals is essential as a tool in classifying health status, diagnosing, establishing treatment regimens, and monitoring the progress of a disease in rescued manatees. We collected blood samples from 44 free-ranging and 26 rescued manatees from Puerto Rico between 1992 and 2020 for hematology and blood chemistry analysis. We obtained values for white blood cell count and red blood cell count, hemoglobin, hematocrit, platelet, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration, and red cell distribution width. A manual leukocyte differential allowed for the evaluation of different cell types. In addition, we performed a comprehensive metabolic panel on serum samples. These analytes were grouped based on six physiologic processes: liver-associated enzymes and pigments; muscle-associated enzymes; kidney-associated compounds and products; sugars, lipids, and pancreatic-associated enzymes; proteins; and electrolytes. For every parameter, summary statistics of values were calculated on all the samples. Reference ranges were determined as ±1 standard deviation around the mean. An unpaired two-sample T-test was done comparing males versus females and adults versus calves for any significant differences (p ≤ 0.05). We establish the reference intervals of hematology and blood chemistry for the population of Antillean manatees in Puerto Rico and compare them with those established for manatees from Belize, Brazil, Florida, Guyana, and Mexico.
Inspection Interval Optimization for Aircraft Composite Tail Wing Structure Using Numerical-Analysis-Based Approach

Recently, there has been a tremendous increase in the use of fiber-reinforced composite (FRCP) in the aviation and aerospace industries due to its superior properties of high strength, stiffness, and low weight. The most important feature of implementing composite materials in aviation is their behavior under dynamic loads and resistance to fatigue. To predict the life of composite structures and optimize the inspection interval, it is essential to predict the damage behavior of composites. In this study, a model of fatigue delamination damage of composite specimens was first constructed using a finite element analysis (FEA)-based approach. The FEA modeling was verified through comparison with experimental specimen data, and the verified FEA model was applied to the composite material aircraft tail wing structure. In this case, a Monte Carlo simulation (MCS) was performed by building a response surface model while considering the uncertainty of the mechanical parameters. Through this process, the risk as a function of flight time could be quantitatively evaluated, and the inspection interval was optimized by selecting the combination with the lowest number of repeated inspections that met the permitted risk criteria.
Bias, Variance and Prediction Error for Classification Rules

We study the notions of bias and variance for classiication rules. Following Efron (1978) we develop a decomposition of prediction error into its natural components. Then we derive bootstrap estimates of these components and illustrate how they can be used to describe the error behaviour of a classiier in practice. In the process we also obtain a bootstrap estimate of the error of a \bagged" classiier.
Promoting Mental Health in Young Adults: A Brief Gratitude-Writing Intervention Reduced Brooding in People Who Ruminate

Positive psychology interventions (PPIs) have the potential to bypass barriers to seeking mental health services by promoting well-being without the cost and stigma. Research on PPIs thus far has focused on depressed individuals as well individuals who sought out PPIs on their own. It is less clear, however, whether the promising findings on PPIs could extend to PPIs effectively reducing levels of vulnerability factors in individuals at risk for depression. Rumination is a perseverative cognitive process and named as a transdiagnostic risk factor for psychopathology. The current study tested the efficacy of a gratitude-writing intervention in college students who had high scores of rumination. Participants completed either the gratitude-writing or distraction task for 4 days. The gratitude-writing exercise was significantly more effective than the distraction exercise in reducing the brooding subtype of rumination and in increasing positive affect. Implications for the use of this intervention include its potential to increase confidence in PPIs and to serve as a stepping stone for young adults to seek mental health resources.
B-Site Fe/Re Cation-Ordering Control and Its Influence on the Magnetic Properties of Sr2FeReO6 Oxide Powders

Double-perovskite oxide Sr2FeReO6 (SFRO) powders have promising applications in spintronics due to their half-metallicity and high Curie temperature. However, their magnetic properties suffer from the existence of anti-site defects (ASDs). Here, we report on the synthesis of SFRO powders by the sol–gel process. The B-site cationic ordering degree (η) and its influence on magnetic properties are investigated. The results demonstrate that the η value is well controlled by the annealing temperature, which is as high as 85% when annealing at 1100 °C. However, the annealing atmospheres (e.g., N2 or Ar) have little effect on the η value. At room temperature, the SFRO powders crystallize in a tetragonal crystal structure (space group I4/m). They have a relatively uniform morphology and the molar ratios of Sr, Fe, and Re elements are close to 2:1:1. XPS spectra identified that Sr, Fe, and Re elements presented as Sr2+, Fe3+, and Re5+ ions, respectively, and the O element presented as O2-. The SFRO samples annealed at 1100 °C in N2, exhibiting the highest saturation magnetization (MS = 2.61 μB/f.u. at 2 K), which was ascribed to their smallest ASD content (7.45%) with an anti-phase boundary-like morphology compared to those annealed at 1000 °C (ASDs = 10.7%) or 1200 °C (ASDs = 10.95%).
Black Holes and Gravitational Properties of Antimatter

The gravitational properties of antimatter are still a secret of nature. One outstanding possibility is that there is a gravitational repulsion between matter and antimatter (in short we call it antigravity). We argue that in the case of antigravity the collapse of a black hole doesn't end with singularity and that deep inside the horizon, the gravitational field may be sufficiently strong to create (from the vacuum) neutrino-antineutrino pairs of all flavours. The created antineutrinos (neutrinos) should be violently ejected outside the horizon of a black hole composed from matter (antimatter). Our rudimentary calculations suggest that both, the supermassive black hole in the centre of our Galaxy and in the centre of the Andromeda Galaxy may produce a flux of antineutrinos measurable with the new generation of one cubic kilometre neutrino telescopes. In addition, we suggest two signatures of antigravity in the case of microscopic black holes which may be eventually produced at CERN: the decay products should exhibit a strong matter-antimatter asymmetry and the Hawking radiation should not be the main mechanism for decay.
Recycling of Cement–Wood Board Production Waste into a Low-Strength Cementitious Binder

Cement is a widely used building material, with more than 4.4 billion metric tons produced in 2021. Unfortunately, the excessive use of cement raises several environmental issues, one of which is the massive amounts of CO2e produced as a by-product. Using recycled materials in the concrete mix is widely employed to solve this problem. A method for minimizing the use of natural cement by substituting it with secondary cementitious material that consists of wood–cement board manufacturing waste has been studied in this paper. The cement in the waste stream was reactivated by a mechanical treatment method—the use of a planetary mill, allowing it to regain its cementitious properties and be used as a binder. Physical and mineralogical analysis of the binder material was performed using X-ray diffraction (XRD), thermogravimetry/differential thermal analysis (TG/DTA) and Brunauer–Emmett–Teller analysis; granulometry and compressive strength tests were also carried out. The results show that the grinding process did not significantly change the mineralogical composition and the specific surface area; it did, however, affect the compressive strength of the samples prepared by using the reactivated binding material; also, the addition of plasticizer to the mix increased compressive strength by 2.5 times. Samples were cured in high-humidity conditions. The optimal water-to-binder (W/B) ratio was found to be 0.7 because of the wood particles that absorb water in their structure. Compressive strength increased as the grinding time increased.
Plasma-Activated Acidic Electrolyzed Water: A New Food Disinfectant for Bacterial Suspension and Biofilm

Food-borne diseases are widespread all over the world, and food safety has attracted much attention. This study is the first to use plasma to activate acidic electrolyzed water (AEW) to obtain a new disinfectant for food processing. The germicidal efficacy of plasma-activated acidic electrolyzed water (PA-AEW) on B. subtilis suspension and biofilm was investigated. Furthermore, the synergistic effect of different bactericidal factors was inferred by investigating the physicochemical parameters of PA-AEW and the influencing factors of bactericidal effect. The results demonstrate that PA-AEW is a highly effective and rapid disinfectant. The killing logarithm (KL) value of PA-AEW on B. subtilis suspension could reach 2.33 log10CFU/mL with a sterilization time of 10 s, which is significantly higher than that of AEW (KL = 0.58 log10CFU/mL) and plasma-activated water (PAW) (KL = 0.98 log10CFU/mL) (significant difference, p < 0.01). Moreover, the KL value of the B. subtilis biofilm of PA-AEW was 2.41 log10CFU/mL, better than that of PAW and AEW (significant difference, p < 0.01), indicating that PA-AEW has important application prospects in food processing. The synergistic effect should come from the interaction between reactive chlorine species (RCS) and reactive oxygen and nitrogen species (RONS) in PA-AEW.
Exciton-phonon relaxation bottleneck and radiative decay of thermal exciton reservoir in two-dimensional materials

We study exciton radiative decay in a two-dimensional material, taking into account large thermal population in the non-radiative states, from which excitons are scattered into the radiative states by acoustic phonons. We find an analytical solution of the kinetic equation for the non-equilibrium distribution function of excitons in the radiative states. Our estimates for bright excitons in transition metal dichalcogenides indicate a strong depletion of radiative state population due to insufficient exciton-phonon scattering rate at low temperatures.
Effects of b -blockers on ventricular repolarization documented by 24-hour electrocardiography in long QT syndrome type 2

BACKGROUND Long QT syndrome (LQTS) is an inherited arrhythmia disorder characterized by ventricular repolarization abnormalities and a risk of sudden cardiac death. The electrophysiological components generating the high risk of arrhythmias in LQTS are prolonged repolarization, increased dispersion of repolarization, and early afterdepolarizations, which are clinically estimated as QT interval, T-wave peak to T-wave end (TPE) interval, and T2/T1-wave amplitude ratio, respectively. In experimental LQTS type 2 (LQT2) models, b -blockers decrease dispersion of repolarization and prevent early afterdepolarizations. In clinical studies in patients with LQT2 , b blockers are more effective against exercise-induced than arousal-induced cardiac events. OBJECTIVES to investigate the effects of b -blocker therapy on repolarization properties in LQT2. METHODS QT and TPE intervals and maximal T2/T1-wave amplitude ratios recorded by 24-hour electrocardiograms before and during b blocker therapy were evaluated in 25 patients with LQT2. RESULTS b -Blocker therapy decreased the maximal T2/T1-wave amplitude ratio from 2.9 6 1.1 to 1.8 6 0.7 ( P , .001), but did not change the pause-induced T2/T1-wave amplitude ratio. Under medication, abrupt maximal TPE intervals were shorter at heart rates of (cid:2) 75 beats/min and maximal QT intervals were shorter at a heart rate of 100 beats/min. CONCLUSION b -Blockers stabilize ventricular repolarization in LQT2 by reducing electrocardiographic early afterdepolarizations and by reducing abrupt prolongation of electrocardiographic dispersion of repolarization and ventricular repolarization duration at elevated heart rates. The effect of b -blockers on pause-induced electrocardiographic early afterdepolarizations is weak. The ﬁ ndings provide electrocardiographic explanation for the protective effects of b -blockers against exercise-induced cardiac events in LQT2.
Synthesis, Microstructural Characterization, Mechanical, Fractographic and Wear Behavior of Micro B4C Particles Reinforced Al2618 Alloy Aerospace Composites

In the current studies an investigations were made to know the effect of 63 micron sized B4C particles addition on the mechanical and wear behavior of aerospace alloy Al2618 metal composites. Al2618 alloy with different weight percentages (2, 4, 6 and 8 wt. %) of 63 micron sized B4C particles reinforced composites were produced by stir cast process. These synthesized composites were tested for various mechanical properties like hardness, compression strength and tensile behavior along with density measurements. Further, microstructural characterization was carried by SEM/EDS and XRD analysis to know the micron sized particles distribution and phases. Wear behavior of Al2618 alloy with 2 to 8 wt. % of B4C composites were studied as per ASTM G99 standards with varying loads and sliding speeds. By adding 63 micron sized B4C particles hardness, compression and tensile strength of Al2618 alloy was enriched with slight decrease in elongation. Further, wear resistance of Al2618 alloy was enriched with the accumulation of B4C particles. As load and speed on the specimen increased, there was increase in wear of Al2618 alloy and its composites. Various tensile fracture surface morphology and worn surface behavior was observed by SEM analysis.
Stochastic perturbations of intermittent maps

This thesis studies statistical properties of intermittent maps. We obtain three new results. First we use an Ulam-type discretization scheme to provide {\em{pointwise}} approximations for invariant densities of interval maps with a neutral fixed point. We prove that the approximate invariant density converges pointwise to the true density at a rate $C^*\cdot\frac{\ln m}{m}$, where $C^*$ is a computable fixed constant and $\frac{1}{m}$ is the mesh size of the discretization. We then study intermittent maps in a random setting. In particular, we study a random map $T$ which consists of intermittent maps $\{\tau_{k}\}_{k=1}^{K}$ and a position dependent probability distribution $\{p_{k,\varepsilon}(x)\}_{k=1}^{K}$. We prove existence of a unique absolutely continuous invariant measure (ACIM) for the random map $T$. Moreover, we show that, as $\varepsilon$ goes to zero, the invariant density of the random system $T$ converges in the $L^{1}$-norm to the invariant density of the deterministic intermittent map $\tau_{1}$. The outcome of Chapter \ref{chapACIM} contains a first result on stochastic stability, in the strong sense, of intermittent maps. Finally, we study the problem of correlation decay of random map built from finitely many intermittent maps with a common neutral fixed point. Using a Young-tower technique, we show that the map with the fastest relaxation rate dominates the asymptotics. In particular, we prove that the rate of correlation decay for the annealed dynamics of the random map is the same as the {\em sharp rate} of correlation decay for the map with the fastest relaxation rate.
Research Reactivity and Distress Protocols for Youth Trauma-related Research: A Scoping Review

Objective: To explore literature regarding youth with Adverse childhood experiences (ACEs), their potential reactivity to research, and research trauma mitigation protocols. Methods: A systematic scoping review was conducted in APA PsychInfo, CINAHL, Embase, and OVID Medline. 2 reviewers screened each article for 12 eligible studies. Quantitative and qualitative studies measuring maltreatment and trauma research responses were eligible. Youth were defined as individuals aged 10-19. Results: No study utilized the ACEs questionnaire with research-related stress measures. Among those that included research reactivity measures, various forms of childhood and youth victimization were considered. The majority of participants did not report feeling upset, with many reporting benefits to participation. Information on protocols for managing distress was available for 11 studies, the most common being the provision of a resource helpsheet and/or referral system. Implications: There is no indication of distress following ACEs-related research, with few studies measuring across the research experience. One study measured follow-up for distress and further action. Additional research may be indicated to assess the effectiveness of these protocols in this population with a follow-up assessment.
The Object Detection, Perspective and Obstacles In Robotic: A Review

A few years back, when the image processing hardware and software were created, it was limited, and most of the time, object detection would fail. , But as with time, the advancement in technology has significantly changed the scenario. A lot of researchers worked in this field to carry out a solution through which they can detect objects in any field, especially in the robotic domain [1]. In today's world, with so much research in the field of deep learning, it is very easy to identify and detect any object using computer vision. This paper focuses on the various deep learning technologies and algorithms through which object detection can be done. A new and advanced deep learning technology known as salient object detection has been discussed. Also, the 3D object detection and the end-to-end approach for object detection are discussed. The existing methods of deep learning through which object detection can be done. The applications in which object detection is being used and the importance of object detection. It also reports; what the predecessors have done, what problems have been solved by them, how they solved these problems, the characteristics of the predecessors' methods and their future work.
Lanostane Triterpenoids and Ergostane Steroids from Ganoderma luteomarginatum and Their Cytotoxicity

Macrofungus Ganoderma luteomarginatum is one of the main species of Ganoderma fungi distributed in Hainan province of China, the fruiting bodies of which have been widely used in folk as a healthy food to prevent tumors. To explore the potential cytotoxic constituents from G. luteomarginatum, the phytochemical investigation on the ethyl acetate soluble fraction of 95% ethanolic extract from the fruiting bodies of this fungus led to the isolation of twenty-six lanostane triterpenoids (1–26), including three undescribed ones (1–3), together with eight ergostane steroids (27–34). The structures of three new lanostane triterpenoids were elucidated as lanosta-7,9(11)-dien-3β-acetyloxy-24,25-diol (1), lanosta-7,9(11)-dien-3-oxo-24,26-diol-25-methoxy (2), and lanosta-8,20(22)-dien-3,11,23-trioxo-7β,15β-diol-26-oic acid methyl ester (3) by the analysis of 1D, 2D NMR, and HRESIMS spectroscopic data. All isolates were assayed for their cytotoxic activities using three human cancer cell lines (K562, BEL-7402, and SGC-7901) and seven lanostane triterpenoids (1, 2, 7, 13, 18, 22, and 24), and one ergostane steroid (34) showed definite cytotoxicity with IC50 values that ranged from 6.64 to 47.63 μg/mL. Among these cytotoxic lanostane triterpenoids, compounds 2 and 13 showed general cytotoxicity against three human cancer cell lines, while compounds 1 and 18 exhibited significant selective cytotoxicity against K562 cells with IC50 values of 8.59 and 8.82 μg/mL, respectively. Furthermore, the preliminary structure–cytotoxicity relationships was proposed.
The consistent coalitional value for hyperplane games

We introduce a value for hyperplane games with coalition structure. This value coincides with the consistent value for trivial coalition structures, and with the Owen value for transferable utility games with coalition structure. Furthermore, we present two characterizations: the first one using a consistency property and the second one using properties of balanced contributions.