Miracle-dz/UniFAR-FTUs huggingface dataset:
Breast Cancer Management During the COVID-19 Pandemic: The Senologic International Society Survey.

Objective In early 2020, the spread of coronavirus disease-2019 (COVID-19) led the World Health Organization to declare this disease a pandemic. Initial epidemiological data showed that patients with cancer were at high risk of developing severe forms of COVID-19. National scientific societies published recommendations modifying the patients' breast cancer (BC) management to preserve, in theory, quality oncologic care, avoiding the increased risk of contamination. The Senology International Society (SIS) decided to take an inventory of the actions taken worldwide. This study investigates COVID-19-related changes concerning BC management and analyzes the will to maintain them after the pandemic, evaluating their oncological safety consequences. Materials and Methods SIS network members participated in an online survey using a questionnaire (Microsoft® Forms) from June 15th to July 31st, 2020. Results Forty-five responses from 24 countries showed that screening programs had been suspended (68%); magnetic resonance imagines were postponed (73%); telemedicine was preferred when possible (71%). Surgeries were postponed: reconstructive (77%), for benign diseases (84%), and in patients with significant comorbidities (66%). Chemotherapy and radiotherapy protocols had been adapted in 28% of patients in both. Exception for telemedicine (34%), these changes in practice should not be continued. Conclusion The SIS survey showed significant changes in BC's diagnosis and treatment during the first wave of the COVID-19 pandemic, but most of these changes should not be maintained. Indeed, women have fewer severe forms of COVID-19 and are less likely to die than men. The risk of dying from COVID-19 is more related to the presence of comorbidities and age than to BC. Stopping screening and delaying treatment leads to more advanced stages of BC. Only women aged over 65 with BC under treatment and comorbidities require adaptation of their cancer management.
Silene thymifolia Sibth. et Sm. (Caryophyllaceae) – A vulnerable species in Romania: Anatomical aspects of vegetative organs

Silene thymifolia (Caryophyllaceae) is considered a rare, vulnerable species in Romania, growing only on Black Sea coastal dunes. Anatomical aspects of the root, stem and leaf of this species are presented in this study. Root, stem and leaves were analysed by brightfield microscopy, with specific staining. The root in cross section exhibited a secondary structure, generated by the activity of phellogen, and vascular cambium, with thick cork, continuous secondary xylem rings. no pith rays, but with cortical air lacunes. The stem had a primary structure with a number of collateral vascular bundles arranged on a single circle, with thick cortical schlerenchymal layers and oxalate crystals in pith cells. The epidermis showed stomata and glandular hairs. The leaf was amphystomatic leaf, with a heterogeneous mesophyll (equifacial type) and embedded vascular bundles, with a rounded mid rib surrounded by a parenchyma sheath. The spongy tissue has some large intercellular air spaces with druses. The mechanical tissue is well developed in the root and stem and poorly developed, represented by few collenchyma elements in the mesophyll, being represented by a continuous schlerenchyma fibers band present in root and stem and collenchyma in the leaf. The secretory histological elements were represented by epidermal glandular hairs and oxaliferous cells (druses) present in stem and leaf.
Remotely Piloted Aircraft: Analysis of the Deployment in Aeronautical Accident Investigation Bureau

This study analyzed Remotely Piloted Aircraft System (RPAS) deployment in the Regional Services of Aeronautical Accidents Investigation and Prevention (SERIPA – Brazil) as a support tool to investigate aviation accidents. Such review is justified by the acquisition and use of this equipment and new technology by investigators since 2017. Research aim was to analyze the perception of SERIPA investigators regarding the usefulness and ease of use of the RPAS equipment. We applied an adaptation of the Theoretical Model of Technology. Methodologically, the study was characterized as exploratory and carried out through an inductive logic and qualitative approach. A case study has been done with 14 investigators belonging to six Brazilian SERIPA units. In conclusion, the respondents deem the RPAS to be useful for aircraft accident investigation, and the equipment is of easy use. RPAS was observed as a tool capable of replacing manned aircraft in some crash sites. The external variable, i.e. crash site characteristics, emerged as a factor that influences the use of RPAS, as well as the transport of RPAS in commercial aircraft.
Sounds of fiction: Songs in the teaching and learning of English and literature / Mohd Rozaidi Ismail … [et al.]

Teaching literature to language learners can be daunting. One of the ways to ensure fun and effective learning is through the incorporation of music or songs in the language classroom. Numerous studies have confirmed the benefits of music or songs in improving learners’ text recall ability and reducing their anxiety. Regardless, the studies have also pointed out a mismatch between teachers’ positive feedback on their incorporation in the language classroom and the actual teaching practice due to some limitations such as lack of resources in finding suitable syllabi-based music or songs and inadequate preparation time. Hence, to overcome these limitations, the present study intends to propose literature-based lyrics of The Necklace, a short story by Guy de Maupassant. The effectiveness of these lyrics have been pilot-tested on a group of language teachers in Kastamonu, Turkey. The results indicate that not only that these teachers are willing to use the lyricised literature in their classroom, but they also agree on its effectiveness in improving comprehension and text recall.
Quenching Hot Rotary Hollow Cylinder by 1-row and 2-row Water Impinging Jet Array

Experimental study has been carried out to investigate transient quenching of rotary hollow cylinder by subcooled water impinging jets (∆Tsub = 55-85K) in 1-row and 2-row inline array. The flow rate of water jets varied from 2.7 to 10.9 L/min, impinging on hot rotary cylinder (Ti =600°C) with rotation speed 10-50 rpm and different curvature ratio (Do/d = 12, 19 and 24). The local average and maximum boiling heat transfer at water jet’s stagnation point revealed effect of studied quenching parameters and multiple jet arrays in the boiling heat transfer. The result showed among the studied parameters, jet’s flow rate and curvature ratio influenced heat transfer in all the boiling regimes. Rotation speed was effective in film and transition boiling regime and strong effect of subcooling was captured in the transition boiling regime. The characteristics of maximum heat flux point in the boiling curve were found to be dependent on the studied quenching parameters as well as array of nozzles. Multiple jet arrays had effect on the spatial variation and rate of boiling heat transfer on quenching surface. The heat transfer enhancement by larger number of rows, i.e. 2row array, was studied based on two approaches of constant single jet’s flow rate and array’s total flow rate. The result shown better heat transfer performance is achieved by increasing number of row in the array while the total flow rate is constant. It was found that by impinging constant water flow rate into the jets, 2-row array with twice the number of impinging jets enhanced heat transfer significantly in film and transition boiling regime in combination with other quenching parameters.
Compatibility of Entomopathogenic Fungi, Beauvaria bassiana (Bals. -Criv.) Vuill. and Metarhizium anisopliae (Metchn) Sorokin Isolates with Different Agrochemicals Commonly Used in Vineyards.

Compatibility studies of biological control agents with different agrochemicals have paramount importance to provide proper guidelines for their integrated use and time of application of these agents. The effect of twenty-one different agrochemical formulations commonly used in vineyards including 10 fungicides, 5 insecticides, 2 acaricides and four plant growth regulators on conidial germination and vegetative growth of entomopathogenic fungi; B. bassiana MN710408 and M. anisopliae MN710409 was tested under laboratory conditions. The results of this study showed that among tested fungicides, copper hydroxide formulation was highly compatible with both fungal isolates, it even stimulated conidial germination at all tested concentrations. Also, Copper- sulphate® showed a high stimulant effect with B. bassiana isolate and to a lesser extent with M. anisopliae isolate. The neonicotinoids were compatible with both fungal isolates at certain concentrations. Lufenuron® showed a stimulation effect to both fungal isolates. Regarding plant growth regulators, the Dormex® formulation completely inhibited conidial germination and vegetative growth of both fungal isolates at field recommended concentration, while other types of these agrochemicals showed various degrees of compatibility depending on the fungal isolate.
Palaeoecological aspects of an Ukrainian Upper Holocene chernozem

A physicochemical, palynological and chronological analysis of a soil profile corresponding to a Haplic Chernozem (FAO, 2015) developed in the Ukrainian steppe allow the interpretation of recent environmental changes that have conditioned its formation. Uniformed under the blackening process, its surface horizon dark color contrasts with yellowish color loessic parental material; it is decarbonated and the organic carbon content on the surface is 2.24%. The texture is silty in surface but sandy in lower horizon denoting a clear wind selection and an energy change in aeolian sedimentation processes. The clays present similar values in the three analyzed horizons. The presence of two discontinuities in the profile has made it possible to distinguish a very sandy blackened horizon of 2500 +/25cal BP chronologies from another silty surface and black chromas of age 1336–1256 cal BP. A total of fifteen pollen types have been identified; superficial horizon (A11) has a high presence of pollen of the Amaranthaceae type, the Poaceae are the most abundant and Quercus gender is identified. The sandy horizon (2A/B) shows Poaceas, Pinus, and Oleaceas presence together pollen of Rosaceas type (14%). Pollen data reveal vegetative changes in the three horizons with the presence of even non-existent species today, linked both to recent anthropicclimatic and holocene-type changes on a millennial scale since the last glacial period.
Molecular mechanism of interaction between human sweet taste receptors and antidiabetic agents of Gymnema sylvestre through docking studies

Diabetes mellitus is a group of metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. It is classified into two types, type1 and type 2. In this study, sequence analysis of taste receptors and docking studies with antidiabetic agents of Gymnema sylvestre had been carried out. The active components gurmarin and gymnemic acid of Gymnema sylvestre inhibit the sweet taste response which are going to act as antidiabetic agents. The results showed that the gurmarin and gymnemic acid showed antidiabetic activity. By using bioinformatics tools such as ExPASy translate tool, tertiary structure prediction and docking, the interaction of these active components had been carried out. The results of the present study, first time identified the binding sites of gurmarin and gymnemic acid in both Taste type 1 Receptor 2 and Taste type 1 Receptor 3 (T1R2/T1R3) receptors.
Mechanics of Advanced Composite Structures

Laminated composite plate Geometric nonlinearity New kinematic function Uniformly distributed load Finite Element Method This paper presents a finite element method (FEM) for linear and geometrically nonlinear behaviours of cross ply square laminated composite plates (LCPs) subjected to a uniform distributed load (UDL) with simply supported boundary conditions (SS-BCs). The original MATLAB codes were written to achieve a finite element (FE) solution for bending of the plate. In geometrically nonlinear analysis, changes in geometry take place when large deflection exists to consequently provide nonlinear changes in the material stiffness and affect the constitutive and equilibrium equations. The Von Karman form nonlinear strain displacement relations and a new inverse trigonometric shear deformation hypothesis were used for deriving the FE model. Here, in-plane displacements made use of an inverse trigonometric shape function to account for the effect of transverse shear deformation. This hypothesis fulfilled the traction free BCs and disrupted the necessity of the shear correction factor (SCF). Overall the plate was discretized using the eight-node isoparametric serendipity element. The equilibriums governing equations associated boundary conditions were obtained by using the principle of virtual work (PVW). The numerical results were obtained for central deflections, inplane stresses and transverse shear stresses for different stacking sequences of cross ply laminates. The results were also computed by the FE software ANSYS for limited cases. The results obtained showed an acceptable agreement with the results previously published. The findings suggested the future use of a new FE model for linear and nonlinear laminated composite plate deformation.
Effects of Vitamin E on FasL-induced Apoptotic Death of Dendritic Cells through PI3K Signaling

This study addresses the effects of vitamin E (VitE) on the survival of mouse dendritic cells (DCs) and on underlying signaling molecules. To this end, mouse bone marrow cells were isolated and cultured to attain bone marrow-derived DCs (BMDCs). The cells were treated with FasL in the presence or absence of VitE. Western blotting and FACS analysis was performed to determine the expression of signaling molecules and their involvement in DC apoptosis. The FasL treatment resulted in activation of caspase 8 and an increased number of Annexin V cells; the effects were significantly suppressed when VitE was present in the cell culture. Importantly, the anti-apoptotic effects of VitE were abolished by using pharmacological inhibition of PI3K signaling with LY294002. The study results show that VitE inhibited FasL-mediated DC apoptosis through PI3K signaling, which is expected to facilitate the survival of DCs and promote the immune response against pathogens.
MOOC Quality Design Criteria for Programming and Non-Programming Students

The purpose of this study is to investigate the quality design criteria for developing a Massive Open Online Course (MOOC). Currently, there are limited studies that highlight the required design criteria for the MOOC programming courses. A descriptive analysis was conducted to examine the characteristics of the three important quality design criteria which are (i) Instructional Design Criteria involving Lecture Organization and Culture; (ii) Technical Criteria involving User Interface, Video Content, Learning and Social Tools, and Learning Analytics; and (iii) E-Assessment. The data were collected from 306 respondents, representing the UUM MOOC students of 2018 class, were further analyzed using the T-Test hypothesis testing to determine whether both the programming and non-programming students require the same quality design criteria. The questionnaire used in this study consists of 46 items related to the MOOC quality design criteria that were adapted from previous studies. The results indicate that out of the nine constructs, four have obtained significant differences in the mean scores, namely the Video Content, Instructional Design, Culture, and E-assessment. This signifies that different quality design criteria are needed for both the programming and non-programming students. The outcome of this study may assist the developers in designing the MOOC by providing the required criteria according to its importance. Keywords: Instructional Design, MOOC, non-Programming, Programming, Quality Design
ASSESSMENT OF COMBINED EFFECT OF HUMAN FECES COMPOST AND SINGLE SUPERPHOSPHATE ON THE BEHAVIOUR OF WHEAT PRODUCTION

Application of organic fertilizers in improving soil fertility has become a major factor that has enabled the world to feed billions of people. However, the required quantities of organic material are enormous, so it becomes necessary to combine different types of fertilizers to feed plants. The effectiveness of human feces compost (HC) alone, as well as in combination with single super phosphate (SSP), was evaluated in the present study. A field experiment was conducted at farmer field located in district Swabi (Pakistan). A total of eight possible treatments combination were arranged in randomized complete block design (RCBD), replicated four times. Two levels of human feces compost (HC), including control (HC0: control and HC1: 7.5 t ha-1) and four levels of P, as single superphosphate (SSP), including control (P0: control, P1:40 kg ha-1, P2: 60 kg ha-1 and P3: 90 kg ha-1) were utilized in the experiment. Results revealed that among all the treatments, combined application of SSP at 60 kg ha-1 along with 7.5t ha-1 HC significantly improved the growth, as well as the yield parameters of wheat crop. These results allow saving a half of usually made mineral fertilizer dose for the cultivation of wheat crop. Combined use of HC and SSP were strongly recommended for obtaining maximum wheat yield in the prevailing soil and environmental conditions.
Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma

Multiple myeloma (MM), the second most common hematologic cancer, is caused by accumulation of aberrant plasma cells in the bone marrow. Its molecular causes are not fully understood and its great heterogeneity among patients complicates therapeutic decision-making. In the past decades, development of new therapies and drugs have significantly improved survival of MM patients. However, resistance to drugs and relapse remain the most common causes of mortality and are the major challenges to overcome. The advent of high throughput omics technologies capable of analyzing big amount of clinical and biological data has changed the way to diagnose and treat MM. Integration of omics data (gene mutations, gene expression, epigenetic information, and protein and metabolite levels) with clinical histories of thousands of patients allows to build scores to stratify the risk at diagnosis and predict the response to treatment, helping clinicians to make better educated decisions for each particular case. There is no doubt that the future of MM treatment relies on personalized therapies based on predictive models built from omics studies. This review summarizes the current treatments and the use of omics technologies in MM, and their importance in the implementation of personalized medicine.
Anti-GD1b and anti-GM1 positive, acute inflammatory demyelinating polyneuropathy associated with advanced ovarian carcinoma: A case report

Introduction: Paraneoplastic neurological syndromes (PNSs) are mostly associated with non-epithelial ovarian cancers. We report the case of an advanced high-grade serous ovarian adenocarcinoma, diagnosed during the etiological investigation of a subacute motor-sensory axonal neuropathy variant (AMSAN) of Guillain-Barre syndrome (GBS). According to our literature review, only a single case-control study described a positive association between GBS and cancer. Case Report: A 73-year-old woman was admitted to the emergency department for a progressive symmetrical distal tetraparesis, associated with hypoesthesia and abdominal pain. There was no sign of viral or bacterial infection. Over a period of 10 days, she presented a rapid neurological deterioration with nearly complete paralysis of all extremity, facial, and respiratory muscles. The laboratory testing ruled out active infection but the computed tomography (CT) scanner described diffuse peritoneal carcinomatosis, associated with bilateral ovarian tumors. Laparoscopic biopsies confirmed a high-grade serous ovarian cancer. Cerebrospinal fluid analysis confirmed the presence of elevated protein with a normal white blood cell count and anti-ganglioside autoantibodies anti-GD1b and anti-GM1. The patient received systemic chemotherapy together with plasmapheresis and intravenous immunoglobulins, and she experienced a rapid neurological recovery and long-term tumor remission. Conclusion: Neurological paraneoplastic syndromes are rarely associated with epithelial ovarian cancer. Cerebellar ataxia is most frequently associated with this cancer type. Guillain-Barre syndrome can rarely be associated with high-grade serous ovarian cancer. It can delay the tumor diagnosis and treatment. In the case of our patient, early supportive and etiological treatment was of paramount importance for the complete recovery of our patient.
HONEYBEE COLLECTED POLLEN AS ANTIBIOTICS TO CONTROL AMERICAN FOUL BROOD DISEASE, AT GIZA GOVERNORATE

he aim of this study was to determine the phenolic compounds and antibacterial activity components of pollen grains, obtained from different concentrations extracts of ethanol and water for controlling American foulbrood (AFB) disease. In this study four Egyptian bee pollen grains types were collected from pollen basket, namely Broad bean (Vicia faba), date palm (Phoenix dactylifera), clover (Trifolium alexandrinum) and maize (Zea mays), during spring. Identification of Phenolic composition in pollen grains samples were investigated by high performance liquid chromatography (HPLC) instrument. Two pollen extracts, using ethanol and water by three concentrations 5, 10 and 20% agent's Paenibacillus larvae subspecies larvae, formerly Bacillus larvae and it's potential for the control of American foulbrood disease (AFB) in vitro. Generally the concentration of 5% gave no effect neither pollen ethanol or aqueous extracts. But pollen grain water extracts gave inhibition zone diameter with different pollen grain of types (10%) and (20%) concentrations. The water extract of date palm pollen grains recorded a highly effect of inhibition zone which were 21.30& 28.65mm with 10&20% concentrations respectively. This study considers a primary step for the pollen grains on P. larvae spores in vitro. These products showed efforts no toxicity effects on different stage of honeybee. Suggesting them as perspective, low cost and consumer-acceptable agent for control of AFB disease in honeybee colonies.