Miracle-dz/UniFAR-FTUs huggingface dataset:
MicroRNA-16 inhibits the growth and metastasis of human glioma cells via modulation of PI3K/AKT/mTOR signalling pathway

Gliomas are lethal cancers accounting for significant human mortality across the globe. MicroRNAs (miRs) have shown potential to act as therapeutic targets for the treatment of cancer. Herein the role and therapeutic implications of miR-16 in glioma were investigated.Expression analysis was carried out by qRT-PCR. CellTiter-Glo assay (Promega) was used for the determination of cell proliferation. DAPI, AO/EB, and annexin V/PI assays were used to detect apoptosis. Wound healing and Transwell assays were used for cell migration and invasion, respectively. Western blot analysis was used for the determination of protein expression.The study revealed that miR-16 was significantly suppressed in the human glioma cells. Ectopic expression of miR-16 in U118 MG cells inhibited the proliferation via induction of apoptosis. The apoptosis induction was also accompanied by an upsurge of Bax and depletion of Bcl-2. The overexpression of miR-16 also inhibited the migration and invasion of the glioma U118 MG cells, as evident from the wound healing and transwell assays, which were accompanied by the inhibition of metalloproteinase-2 and -9 (MMP-2 and MMP-9). The effects of miR-16 overexpression were also examined on the PI3K/AKT/mTOR signalling pathway. The results showed that miR-16 overexpression inhibited the phosphorylation of the p70S6K, AKT, and mTOR at Ser473, Ser2448, and Thr389, respectively, with no apparent effects on the total PI3K and AKT.miR-16 acts as tumour suppressor in glioma and may severe as therapeutic target for glioma treatment.
Exploring Telepractice for Stuttering: A Case Study

Purpose:​ The purpose of this research was to describe how telepractice can be used as a speech-language pathology service delivery model with a school-age child who stutters. Specifically, the research questions were: 1) Can a school-age client who stutters increase their use of stuttering modification strategies to manage their stuttering through telepractice? 2) Can a school-age client who stutters increase acceptance of stuttering through telepractice treatment? Methods:​ The participant in the study was a 12-year-old female who stutters who received weekly speech-language pathology treatment sessions via telepractice for nine months. Outcome measures for this study were: disfluency counts (% of words stuttered; % of total disfluencies), responses to the Overall Assessment of the Speaker’s Experience of StutteringSchool-age Version (OASES-S), accuracy using stuttering modification techniques, and participant drawings of her speech/stuttering. Result: ​Result showed that a school-age client who stutters can indeed increase their use of stuttering modification strategies to manage their stuttering through telepractice. Results also revealed that the client increased self-acceptance of stuttering through telepractice treatment. Conclusion: ​Results of the current study support the notion that telepractice services with a school-age child can be successful for both managing stuttering moments and increasing self-acceptance of stuttering.
Effect of vermicompost and phosphate solubilizing bacteria on growth and yield of potato (Solanum tuberosum L.)

Field investigation was carried out to study the effect of organic and biofertilizers on growth and yield parameters in potato cultivar Kufri Chipsona-3 at School of Agriculture and Environmental Sciences, Shobhit University, Gangoh Saharanpur, Uttar Pradesh condition during 2016-2017 and 2017-2018. The experiment was laid out in a randomized block design with four nutrient management practices vermicompost (VC), and their combinations with biofertilizers (PSB). Growth parameters like plant height, number of compound leaves per plant, number of shoots per plant, diameter of stem and number of stolon per plant, number of branches per plant, fresh and dry weight of shoot and yield attributing parameters like fresh and dry weight of tubers per plant, number of tuber per plant, diameter of tuber per plant and total yield per hectare increased with the application of vermicompost in different combination rates with biofertilizers was much better than applying of vermicompost one and the using of phosphate solubilizing bacteria with them in tries combinations were the most effective treatments comparing with the others. However, highest values for number of tuber per plant and per plot as well as tuber yield per plot and per hectare was recorded on application of Vermicompost @ 6 t/ha + PSB @ 10 kg/ha was the most effective treatment both the years followed by Vermicompost @ 6 t/ha, respectively.
Normative Data of the Corpus Callosum Index and Discriminant Validity in Patients with Multiple Sclerosis

Background: The corpus callosum (CC) plays an important role in many cognitive and behavior functions and can be easily identified by conventional Magnetic Resonance Imaging (MRI). For these reasons, its integrity has been used as predictor of symptoms in different pathologies. Methods and findings: to provide standardized data of the corpus callosum index (CCI) and obtain a cut-off point as a possible early marker of cognitive impairment in multiple sclerosis (MS), 209 healthy subjects and 96 patients were consecutively evaluated with a brain MRI scanning protocol. CCI was measured by two blinded raters. ROC curves were obtained for the total of sample and subgroups and the Youden Index was calculated to indentify the best cut-off points. Results: Normative data of CCI are presented by age. No sex differences were found. Cut-off points were established for subjects in different age groups.
Structure and Features of Politically-Invested Hoaxes

Hoaxes and their spread in social media have led various politicians led to legal issues and a few of them have born legal jail or financial consequences due to hoaxes and other fake news. These should have been avoidable if the fake news makers have understood two essential points. Firstly, understanding and loyalty to politically correct communication when communicating in public evading ethnic, religion, race, inter-group, and sexual orientation of the communication partners. Secondly, understanding the textual and linguistic features of fake news and refraining themselves from spreading them becomes essential. Theoretically, every text produced and reproduced by the news makers serve certain social functions, textual structures, and linguistic features. Functionally, hoax news is produced and reproduced for the purpose of spreading incorrect and untrue information about certain political issues so that readers change their mind or political affiliation. Such political agenda are textually engineered within the textual structure which is in turn realized within certain types of sentences, clauses, phrases, and words.
Partnership for inclusive growth: Can linkages with large firms spur the growth of SMEs in Tanzania?

A recent strand of literature on small and medium enterprise (SME) development identifies linkages with large firms as some of the enablers of development and competitiveness. However, there is a dearth of empirical studies on the topic. In this study, we assess the extent and determinants of linkages between SMEs and large firms in Tanzania and to what degree the linkage is an important driver of SME performance.
HEALTHY BEHAVIOR OF PHYSICAL EDUCATION UNIVERSITY STUDENTS

Authors’ contribution Wkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane – analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. Literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary The purpose of this study is to examine the healthy behaviors in undergraduate students of physical education (PE) with a comparison between gender and majors. A content analysis of Polish and foreign authors’ publications was performed by searching the following database: EBSCO, Proquest, Science Direct (Elsevier), Springer, Sage, and Wiley. Research indicates that undergraduates demonstrate, in general, low levels of healthy lifestyle behaviors, especially regarding diet, psychoactive substance use, coping with stress, physical activity and preventive behavior. PE students present with a high level of health-risk behavior. On the other hand, some research showed that PE students scored better than their peers of other areas of study in selected dimensions of health-related behavior. The majority of studies indicate that female students scored significantly better than male students in health-related behavior. Health promotion programs should be implemented at campuses and universities for the maintenance and improvement of a healthy lifestyle among students of all areas of study.
Laboratory Observations of the Veronicellid Slug Biology Laevicaulis stuhlmanni aegypti Ali & Robinson, A new Subspecies and Record in Egyptian Agro-system

The veronicellid slug Laevicaulis stuhlmanni aegypti Ali & Robinson (Family: Veronicellidae) is a new subspecies and record that had been discovered for the first timein garden in El Zamalek at Cairo governorate, Egypt.The main biological aspects of theveronicellid slug had been recorded i.e., incubation period, hatchability percentage, life cycle, oviposition, generation period as well as life span. These observations were recorded under laboratory conditions during slug’s activity season starting from March till early December. Biology of veronicellid slug had not adequate study of their life cycle and behavior, especially for new subspecies record in the Egyptian environment. Self-fertilization is the normal breeding system for laying eggs; with big number of egg clutches, that makes the slug is a dangerous invader pest with population for attacking any new environment in the future.
Continuous curve textures

Repetitive patterns are ubiquitous in natural and human-made objects, and can be created with a variety of tools and methods. Manual authoring provides unmatched degree of freedom and control, but can require significant artistic expertise and manual labor. Computational methods can automate parts of the manual creation process, but are mainly tailored for discrete pixels or elements instead of more general continuous structures. We propose an example-based method to synthesize continuous curve patterns from exemplars. Our main idea is to extend prior sample-based discrete element synthesis methods to consider not only sample positions (geometry) but also their connections (topology). Since continuous structures can exhibit higher complexity than discrete elements, we also propose robust, hierarchical synthesis to enhance output quality. Our algorithm can generate a variety of continuous curve patterns fully automatically. For further quality improvement and customization, we also present an autocomplete user interface to facilitate interactive creation and iterative editing. We evaluate our methods and interface via different patterns, ablation studies, and comparisons with alternative methods.
High-Power Density Inertial Energy Harvester Without Additional Proof Mass for Wearables

Inertial energy harvesters have great potential to sustainably power wearable sensors for the Internet of Things. However, the bulky proof mass used to capture kinetic energy limits the power density of such an energy harvester. Targeted for high-power density, we propose an inertial energy harvester without additional proof mass to efficiently scavenge the kinetic energy of human limb swing. By adopting a planetary structure, the power generation unit, comprising the base, coils, rotor, and magnets, serves as an eccentric weight of the system, so no additional proof mass is needed. Excited by limb swing, the power generation unit oscillates along the sun gear so that the rotor is actuated by the sun gear to spin and produce electricity. We build a theoretical model to predict the average output power under limb swing excitations. We fabricate a miniature prototype to experimentally characterize the energy harvester under pseudowalking excitation and evaluate its performance in real walking. The results show that the prototype generates a maximum power of 1.46 mW and power density of $454.82~{\mu }\text{W}$ /cm3 in pseudowalking testing, which are over ten times those of its counterparts. In the real walking test, the prototype performed even better, achieving 1.84 and 2.95 mW when worn on the wrist and ankle, respectively. After power regulation, the energy harvester can fully power a pedometer at various walking speeds. Finally, simulations using real walking data demonstrate that the proposed device reaches higher power density compared with conventional structures and that introducing the additional proof mass unnecessarily increases power density.
Partial molecular characterization of begomoviruses isolated from weeds collected in tomato crops in the southeast of Valle del Cauca, Colombia

Weeds are usually considered as a source of new viruses but are often neglected during diversity studies. Previously eleven samples of weeds were collected along the edges of a tomato crop field located in four municipalities (Florida, Ginebra, Cerrito and Candelaria) in the Southeast of Valle del Cauca. These samples were positive for begomoviruses but their molecular characterization had not been done until now. For each sample, DNA fragments were cloned, sequenced and analyzed. Nucleotide sequence analysis of viral fragments showed the presence of six different begomoviruses: two virus isolated from Lantana camara, Desmodium sp. and Amaranthus dubius were previously described as potato yellow mosaic virus (PYMV) and passionfruit leaf distortion virus (PLDV), respectively; other four virus which were isolated from L. camara, A. dubius, Rivina humilis, Desmodium sp. , Rhynchosia minima, Hybanthus attenuatus, Verbena sp. , Croton hirtus and Caesalpinia sp. , showed its highest nucleotide sequence identity (89%) with bean chlorotic mosaic virus (BChMV), datura leaf distortion virus (DaLDV) and rhynchosia golden mosaic Yucatan virus (RhGMYV). Cloned viruses fragments from these weeds could be new begomoviruses not previously reported before, this in accordance with the ICTV species demarcation criterion for the genus Begomovirus (≥91 % sequence identity). Mixed infections of begomoviruses in Desmodium sp. and A. dubius weeds also was found in this analysis. Finally, this paper reports by the first time to three alternative begomoviruses weeds hosts that infect tomato and passion fruit crops: A. dubius for PYMV, and L. camara and Desmodium sp. for PLDV, respectively.
Some recent progress on inverse scattering problems within general polyhedral geometry

Unique identifiability by finitely many far-field measurements in the inverse scattering theory is a highly challenging fundamental mathematical topic. In this paper, we survey some recent progress on the inverse obstacle scattering problems and the inverse medium scattering problems associated with time-harmonic waves within a certain polyhedral geometry, where one can establish the unique identifiability results by finitely many measurements. Some unique identifiability issues on the inverse diffraction grating problems are also considered. Furthermore, the geometrical structures of Laplacian and transmission eigenfunctions are reviewed, which have important applications in the unique determination for inverse obstacle and medium scattering problems with finitely many measurements. We discuss the mathematical techniques and methods developed in the literature. Finally, we raise some intriguing open problems for the future investigation.
Structure of the phenotypic variability of fruit and seeds of Dipteryx alata vogel (Fabaceae)

Abstract Dipteryx alata Vogel (“baru tree”) is a fruit species native to the Brazilian Cerrado and presents a multiplicity of uses, constituting a priority species for domestication and cultivation studies. The objective of the current study was to characterize fruit and seeds of D. alata from several regions of the Brazilian Cerrado biome to support strategies for ex situ conservation and utilization of the genetic variability of the species. Fruits were collected from 25 subpopulations, sampling six mother plants per subpopulation, with collection of at least 25 fruits per plant. The physical trait data of the fruits and seeds were submitted to descriptive analysis, analysis of variance and correlation among traits. There was significant variation for all traits among subpopulations and among individuals within subpopulations. The highest proportion of variability was observed among individuals within subpopulations. The phenotypic differentiation among subpopulations was higher for fruit traits compared to seed traits. The correlation analysis showed the existence of significant correlations for most of the traits pairs in the different hierarchical levels. It was concluded that D. alata presents phenotypic variability to support germplasm collection programsand formation of base populations for breeding programs, recommending the sampling in several locations to ensure an adequate representativeness of the phenotypic variability.
Prognostic model of clinical scores in evaluation of treatment outcome in patients with acute Achilles tendon rupture - surgery vs. immobilization

Introduction/Objective. When choosing the appropriate treatment for Achilles tendon rupture, there may be a dilemma when choosing the optimal treatment. The objective of this study was analyzing groups of patients with acute closed Achilles tendon injury, comparing early recovery and functional parameters in relation to treatment and first choice treatment suggestion. Methods. The prospective study included 80 patients with acute Achilles tendon rupture. The treatment was surgery or immobilization. Results. There is a difference in the mechanism of injury between surgically and non-surgically treated (p = 0.026). In total, 50 (62.5%) patients were operated and 30 (37.5%) patients were treated with circular plaster. The difference (p = 0.000) between the groups in the duration of treatment, The American Orthopaedic Foot and Ankle Society (AOFAS) score and Visual Analogue Scale of pain (VAS) was shown. Patients undergoing surgery in the first two days had better clinical results in terms of The Achilles tendon Total Rupture score (ATRS), AOFAS and VAS. Higher satisfaction was achieved in younger people (p = 0.036). Patients whose treatment lasted shorter were more satisfied with their status (p = 0.001). ATRS and AOFAS score are higher in patients who are more satisfied with their own status (ATRS p = 0.301; AOFAS score p = 0.001). Six months after the treatment, 78.75% (63/80) of patients were fully functional. Conclusion. The therapy of choice in the treatment of acute Achilles tendon rupture is surgical, as surgical treatment is shorter; rehabilitation is faster and shorter, and the total costs associated with treatment and absence from work are lower.
The Effect of Cattle Seminal Plasma Crude Protein on the Cryopreservation of Goat Semen

This study aimed to improve the quality of cryopreserved goat semen for artificial insemination by the addition of cattle seminal plasma crude protein. Semen collected from cattle and centrifuged to obtain seminal plasma. Then it was purified to obtain the crude protein. The diluent used in this study was milk-yolk. There were three groups, control group without crude protein (P0), the addition of 2.5 mg crude protein/mL diluent (P1); and the addition of 5 mg crude protein/mL diluent (P2). The results showed that P1 had the highest percentage of progressive motility and viability. Meanwhile, P1 had the lowest percentage of cytochrome C expression. The lowest cytochrome C expression indicates that the mitochondria have a good function. So, by the addition of 2.5 mg crude protein/mL diluent, the quality of frozen goat semen in terms of sperm motility, viability, and cytochrome C expression in the spermatozoa could be improved.
Lichens as biomonitors for manganese and lead in Pretoria, South Africa.

Parmotrema austrosinense (Zahlbr.) Hale lichens were collected from the Pretoria central business district (CBD), as well as three sites to the east of Pretoria; the National Botanical Gardens, the CSIR campus and the suburb of Lynnwood, with the aim of utilising these lichens as biomonitors of air quality to determine the effects of the phasing out of leaded petrol and the simultaneous introduction of manganese anti-knock additives to fuel in South Africa. In addition to lichens, roadside dust and soil samples were collected from the CBD and CSIR campus, and all samples were analysed by flame atomic absorption spectrometry after acid digestion. There was no significant difference (95 % confidence) between the Mn content of lichens from all sampling sites (overall average of 97.1 ± 39.1 μg.g, n= 28), which was most likely due to an even suspension of Mn-containing particles arising from soil dust. Additional contributions to Mn loading as a result of vehicle emissions were currently not evident. For all non-CBD sites, higher Pb levels were found in lichens which were nearer to busy roads, suggesting an historical impact by vehicular emissions of Pb arising from leaded petrol usage. The Pb concentrations in lichens found in the CBD (average of 181.1 ± 98.0 μg.g, n=10) were significantly higher (95 % confidence limits) than those of lichens growing outside of the CBD area (average of 41.5 ± 36.4 μg.g, n=18), and the Pb levels were higher than those of Mn, which was contrary to that found in sites outside the CBD.
A Comparison of Special Bonding Techniques for Transmission and Distribution Cables Under Normal and Fault Conditions

In this article, a review of the existing special bonding techniques for medium voltage and high-voltage cables is presented. Special bonding techniques have the purpose of reducing sheath currents, thereby limiting copper losses and the reduction of the ampacity of cables. The literature review shows various bonding techniques and how these have evolved over the years thanks to new technologies. Simulations of each technique are performed in MATLAB/Simulink, to compare their strengths and drawbacks both under normal conditions and in the presence of a single-line-to-ground fault.
Study of Lateral Merger of Vapor Bubbles During Nucleate Pool Boiling In the present work the bubble dynamics and heat transfer associated with lateral bubble

The bubble dynamics and heat transfer associated with lateral bubble merger during transition from partial to fully developed nucleate boiling is studied numerically. Complete Navier-Stokes equation in three dimensions along with the continuity and energy equations are solved using the SIMPLE method. The liquid vapor interface is captured using the Level-Set technique. Calculations are carried out for multiple bubble mergers in a line and also in a plane and the bubble dynamics and wall heat transfer are compared to that for a single bubble
Students’ Perception of Edmodo use as a Learning Tool

Due to the development of technology, teachers are expected to integrate technology into the classroom to engage the Z Generation students. Edmodo is a popular online learning platform that has now been widely used as a learning management system in blended learning or just as a supplementary tool. This study aims at investigating students' perceptions of Edmodo as a learning tool. Involving 47 students of the English department of Universitas Kristen Indonesia, data were collected employing a questionnaire and an interview. The results showed that the participants perceived Edmodo use improved their language skills, developed interaction and communication, enhanced the freedom to share ideas, and promoted their vocabulary and creativity. However, they regarded that the traditional face-to-face learning should not be replaced by online learning. They seemed to suggest the two learning modes combined.