Miracle-dz/UniFAR-FTUs huggingface dataset:
Feedlot rearing versus pasture grazing enhances plasma leptin and insulin-like growth factor-1 concentrations but does not anticipate puberty in dairy buffalo (Bubalus bubalis) heifers

Abstract Plasma Leptin (LEP) and Insulin-like Growth Factor-1 (IGF-1), related to growth and puberty onset, were assayed in growing buffalo heifers from 8 up to 21 months of age, reared in feedlot (FR, n = 13; initial body weight 132 ± 11 Kg) or grazing at pasture (PG, n = 13; 137 ± 12 Kg). The mean age at puberty was not different between the two groups (599.5 and 610.5 days, in FR and PG, respectively). At puberty, FR heifers showed higher BCS, and higher average daily weight gain (DWG) than PG ones (0.87 vs. 0.62 Kg/day), and were heavier (462 vs. 375 Kg). A negative correlation between DWG and age at puberty was significant for the PG group. Plasma Inhibin-A increased in both groups one month before puberty. Plasma LEP and IGF-1 sharply increased 2 months before puberty (about 18 months old) in FR heifers only, which showed higher concentrations of both hormones than PG heifers. Plasma LEP levels correlated positively with body weight and IGF-1. Despite hormone levels being affected by rearing systems, and being lower in heifers grazing at pasture, these latter experienced adequate growth and reproductive maturation. In fact, grazing heifers reached puberty at the same age as the feedlot reared ones, with shorter puberty–conception interval (51.3 vs. 67.2 days, for PG and FR groups, respectively) and no difference in conception rates (83.3 and 84.6%, for PG and FR groups respectively). The higher BW and DWG of FR heifers were due to body fat deposition, which did not anticipate the puberty onset. Highlights Metabolic hormones Leptin and IGF-1, linked to puberty attainment, are good indicators of the animal energetic state. Buffalo heifers reared in intensive system vs. the ones at pasture had higher hormone levels and growth, but reproductive performance was not better. Post-weaned heifers can be reared at pasture during growth and breeding, without compromising reproductive performance.
A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson’s disease model

As a neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP)-preferring receptor, PAC1-R mediates effective neuroprotective activity. Based on the finding that the antibiotic doxycycline (DOX) with clinical neuroprotective activity functions as a positive allosteric modulator (PAM) of neuropeptide PACAP receptor 1 (PAC1-R), we use virtual and laboratory screening to search for novel small molecule PAMs of PAC1-R. Virtual screening is carried out using a small-molecule library TargetMol. After two-level precision screening with Glide, the top five compounds with the best predicted affinities for PAC1-R are selected and named small positive allosteric modulator 1‒5 (SPAM1‒5). Our results show that only 4-{[4-(4-Oxo-3,4-2-yl)butanamido]methyl}benzoic acid (SPAM1) has stronger neuroprotective activity than DOX in the MPP+ PD cell model and MPTP PD mouse model. SPAM1 has a higher affinity for PAC1-R than DOX, but has no antibiotic activity. Moreover, both SPAM1 and DOX block the decrease of PAC1-R level in mouse brain tissues induced by MPTP. The successful screening of SPAM1 offers a novel drug for the treatment of neurodegenerative disease targeting the PAC1-R.
Non-commutative Field Theory, Translational Invariant Products and Ultraviolet/Infrared Mixing

We review the Moyal and Wick-Voros products, and more in general the translation invariant non-commutative products, and apply them to classical and quantum field theory. We investigate phi^4 field theories calculating their Green's functions up to one-loop for the two- and four-point cases. We also review the connections of these theories with Drinfeld twists.
ENGLISH STUDENTS’ SELF-RESILIENCE AND CHALLENGES IN DISTANCE LEARNING

Due to the Covid-19 epidemic, learning has shifted from offline to online, affecting pupils' learning resilience and the complexity of learning obstacles. As a result, the focus of this study is on English students' resilience and the obstacles they experience during distance learning. This study used qualitative methodologies and included 20 English students who were purposefully chosen as participants. They were questioned in accordance with the study's objectives. An interactive model was used to analyse the interview data. The data suggest that in remote learning, students' self-control is lacking. They are under psychological duress. Their physical state was deteriorating, and several of them were experiencing headaches. They are mentally bored and unable to concentrate, and they cannot enjoy learning due to a lack of social interaction. Furthermore, students encounter issues connected to internet signals, budgeting to meet internet demands, and difficulty in locating learning resources during remote learning, all of which are classified as examples of poor technical competence.
Are Hepatic Vein Waveform and Damping ‎Index Valuable in Prediction of Esophageal ‎Varices in Cirrhotic Patients?‎ ‎‎

with esophageal varices. Group (2): 22 patients without esophageal varices. Results: Twenty five out of 26 patients (96.2%) with esophageal varices and 90% of patients in Child Pugh class C had monophasic waveform. There is no significant relation between severity of ascites and HVW. Among all patients, 30 patients (62.5%) had DI >0.6, without significant predominance to presence of esophageal varices, certain Child Pugh class, degree of ascites or certain HVW. There is significant correlation between damping index and Child Pugh score. Conclusion: Monophasic hepatic vein waveform is a good non-invasive indicator for the presence of esophageal varices and advanced cirrhosis. DI is of no value in predicting esophageal varices, but significantly correlated with Child Pugh score.
International identity construction: China’s pursuit of the responsible power identity and the American Other

How should one understand the construction of a state’s identity in the international system—its international identity? In this article, I attempt to provide richer answers. Drawing insights from social psychology, specifically Social Identity Theory and Identity Theory, I provide a micro-account of identity construction to better specify the mechanisms and logics through which international identity is constructed. This framework proposes the following general arguments about international identity formation. First, the construction of international identity is interpreted as a process of role negotiation between the state Self and relevant Other, animated by the mechanisms of self-categorization, alter’s casting, and role appraisal. Second, the collective motivations of self-esteem, self-efficacy, and self-consistency drive state identity change or continuity. As a plausibility probe, I apply the framework to a current analysis of China’s construction of an international identity as a “responsible” power in recent years, with a corresponding focus on the United States as the primary Other.
Cultivating the Humanistic Quality of Nursing Undergraduates in the Internet Age

Humanistic quality refers to the research ability, knowledge level of the humanities, and the human inner quality of the humanities. The purpose of this paper was to make a research on the cultivation of humanistic literacy of nursing undergraduates in the context of the Internet era. This paper first makes a general introduction of the classification of the Internet and the definition of humanistic literacy, analyzes the results of two rounds of expert consultation method, and then obtains the current situation of nursing undergraduates through the questionnaire survey of school nursing undergraduates. The experimental results showed that in the current survey situation, the expert support rate of humanistic care is as high as 90%, indicating that humanistic care is especially important for a nursing undergraduate. The total score of humanistic nursing ability of undergraduate nursing students was 127.03, which is in the middle level higher than that of most domestic studies, but lower than that of American nursing students.
CLASSICAL EQUIVALENCE AND QUANTUM EQUIVALENCE OF MAGNETIC FIELDS ON FLAT TORI

Let M be a real 2m-torus equipped with a translation-invariant metric h and a translation-invariant symplectic form ! ; the latter we interpret as a magnetic field on M. The Hamiltonian flow of half the norm-squared function induc ed by h on TM (the "kinetic energy") with respect to the twisted symplectic form ! TM + � � ! describes the trajectories of a particle moving on M under the influence of the magnetic field ! If (! ) is an integral cohomology class, then we can study the geometric quantization of the symplectic manifold (TM,! TM + � � ! ) with the kinetic energy Hamiltonian. We say that the quantizations of two such tori (M1,h1,! 1) and (M2,h2,! 2) are quantum equivalentif their quantum spectra, i.e., the spectra of the associated quantum Hamiltonian operators, coincide; these quantum Hamiltonian operators are proportional to the hj-induced bundle Laplacians on powers of the Hermitian line bundle on M with Chern class (! ). In this paper, we construct continuous families {(M,ht)}t of mutually nonisospectral flat tori (M,ht), each endowed with a translation-invariant symplectic structure ! , such that the associated classical Hamiltonian systems are pairwise equivalent. If ! represents an integer co- homology class, then the (M,ht,! ) also have the same quantum spectra. We show moreover that for any translation-invariant metric h and any translation-invariant symplectic structure ! on M that represents an integer cohomology class, the associated quantum spectrum deter- mines whether (M,h,! ) is Kahler, and that all translation-invariant Kahler str uctures (h,! ) of given volume onM have the same quantum spectra. Finally, we construct pairs of magnetic fields (M,h,! 1), (M,h,! 2) having the same quantum spectra but nonsymplectomorphic clas- sical phase spaces. In some of these examples the pairs consist of Kahler manifolds.
Semantic focus mediates pitch auditory feedback control in phrasal prosody

ABSTRACT This study investigated the effect of semantic focus on pitch auditory feedback control in the production of phrasal prosody through an experiment using pitch-shifted auditory feedback. We hypothesized that pitch-shift responses would be mediated by semantic focus because highly informative focus types, such as corrective focus, impose more specific constraints on the prosodic form of a phrase and require greater consistency in the production of pitch excursions compared to sentences with no such focus elements. Twenty-eight participants produced sentences with and without corrective focus while their auditory feedback was briefly and unexpectedly perturbed in pitch by +/−200 cents at the start of the sentence. The magnitude and latency of the reflexive pitch-shift responses were measured as a reflection of auditory feedback control. Our results matched our prediction that corrective focus would elicit larger pitch-shift responses, supporting our hypothesis that auditory feedback control is mediated by semantic focus.
USING PEPPER (CAPSICUM ANNUUM L) AND EGGPLANT (SOLANANUM MELONGENA) VINES IN LACTATING COW DIETS

SUMMARY Total of thirty six lactating Balady cows were selected at 2 month after parturition with average body weight 461.17kg to study the effect of replacing clover hay (CH) by eggplant or pepper vines in cows diets on nutrient digestibilities, feeding value, milk production and some blood constituents. Six similar groups of animals (6 cows/group) were randomly allocated on the dietary treatments of the experiment. Group T1 (control) were given the concentrate feed mixture (CFM) and CH (50:50). While T2 and T3 groups were fed diets included pepper vines (PV) at rate with 12.5 and 25% respectively and at the same previous rate of eggplant vines (EV) was offered to cow groups (T4 and T5), while T6 group was fed on combination of (PV+EV) at 12.5% for each one in replacing to (CH) in control ration, for 3 months as an experimental period. Results revealed that the digestion coefficients of all nutrients and feeding values were significantly (P<0.05) higher for T4 followed by T3 ration and then T2 one in comparison with the control group and the other tested rations. The results also indicated that the actual milk yield and 4% FCM were significantly higher in the treatments containing pepper vines at both levels (T2 and T3) as well as the treatment containing the lowest level of eggplant vines (T4) compared to those of control (T1) and the other tested rations (T5 and T6). The same trend was observed with the percentages of fat and protein in milk, where the treatments T2, T3 and T4 were distinguished in their content from the rest of the treatments, although there were no significant differences between all treatments. Also, in most cases, the rest of the milk components ratios (total solids, solids non-fat and lactose) are distinct in the aforementioned treatments compared to the rest of the other experimental treatments. Insignificant differences in feed intake and feed conversion were observed among the dietary treatments, except the value of the T6 respecting feed conversion that proved the poorest one significantly as DM: 4%-FCM. The results also recorded that the economic efficiency was marked improved in treatments T3 and T4 compared to the other groups. The highest concentrations of total protein and albumin in the blood were in the animals fed a low-level diet of eggplant vines (T4) compared to all treatments of the feeding experiment, and there were almost no significant differences between the treatments with regard to these measures. Therefore, the replacement of clover hay with pepper and eggplant vines up to 12.5% in dairy cow rations is highly recommended in the practical feeding of cows.
Anticipatory Postural Adjustments During Gait Initiation in Stroke Patients

Prior to gait initiation (GI), anticipatory postural adjustments (GI-APA) are activated in order to reorganize posture, favorably for gait. In healthy subjects, the center of pressure (CoP) is displaced backward during GI-APA, bilaterally by reducing soleus activities and activating the tibialis anterior (TA) muscles, and laterally in the direction of the leading leg, by activating hip abductors. In post-stroke hemiparetic patients, TA, soleus and hip abductor activities are impaired on the paretic side. Reduction in non-affected triceps surae activity can also be observed. These may result in a decreased ability to execute GI-APA and to generate propulsion forces during step execution. A systematic review was conducted to provide an overview of the reorganization which occurs in GI-APA following stroke as well as of the most effective strategies for tailoring gait-rehabilitation to these patients. Sixteen articles were included, providing gait data from a total of 220 patients. Stroke patients show a decrease in the TA activity associated with difficulties in silencing soleus muscle activity of the paretic leg, a decreased CoP shift, lower propulsive anterior forces and a longer preparatory phase. Regarding possible gait-rehabilitation strategies, the selected studies show that initiating gait with the paretic leg provides poor balance. The use of the non-paretic as the leading leg can be a useful exercise to stimulate the paretic postural muscles.
Zero shifts due to non-proportional damping

A Coriolis flowmeter produces a signal directly proportional to the mass flow rate of a fluid. A zero shift is defined as the signal produced by the flowmeter at a mass flow rate of zero. This paper explores the effects of non-proportional damping on zero shifts in Coriolis flowmeters. An idealized finite element model of a Coriolis flowmeter is perturbed to explore the effects of localized damping changes, which result in a non-proportional damping matrix. A non-proportional damping matrix is not diagonalized by the modal transformation, which results in coupled modal domain equations of motion. This paper shows how the presence of the small off-diagonal terms in the transformed damping matrix can lead to modal responses in modes that are not excited by the modal force vector. The modal superposition of undesirable modes has been shown to be responsible for zero shifts in Coriolis sensors. This paper shows how these very slight damping changes can result in significant zero shifts.
Combined lactophenol methylene blue-blue glycerol jelly technique as a new approach for helminths staining

different tissues and organs of helminths, the process is time consuming. In addition, the critical step ABSTRACT Background: Permanent staining of helminths is important for different purposes including taxonomic and prevalence studies as well as teaching. Carmine is one of the most commonly used dyes; however, variable factors affect the quality of the staining outcomes. Therefore, it is essential to find an alternative stain that is efficient, accurate, and less complex. Objective: The aim of the present study is to evaluate the quality of a combined lactophenol methylene blue-blue glycerol jelly (LMB-BGJ) technique as a potential alternative for staining of helminths compared with carmine-based staining and glycerol jelly mounting techniques. Material and Methods: S. mansoni and T. spiralis were obtained from experimentally infected animals. A new staining technique (LMB-BGJ) was used for both parasites in comparison with carmine stain in case of S. mansoni and glycerol jelly mounting in case of T. spiralis . Comparison was conducted using examination under light microscope and a mean score was given for the structural brightness, and extent of staining of tegument/cuticle, suckers, intestine, as well as reproductive systems. Results: S. mansoni worms prepared with both carmine staining and LMB-BGJ showed moderate staining quality of tegument,
Differential Protein Content between Fresh and Freeze-Dried Plasma Rich in Growth Factors Eye Drops

The purpose of this study was to analyze the proteomic composition of plasma rich in growth factors eye drops (PRGF) in comparison to lyophilized PRGF eye drops (PRGF lyo). The differential protein expression of keratocyte (HK) cells after PRGF or PRGF lyo treatment was also determined. Blood from different donors was collected and processed to obtain PRGF and PRGF lyo eye drops. Then, HK cells were treated with both formulations. A proteomic analysis was performed to evaluate the differential proteomic profile between PRGF and PRGF lyo, and the differential protein expression by HK cells after treatment with both blood-derived products. About 280 proteins were detected between both blood-derived formulation, with only 8 of them reaching significant differences. Furthermore, 101 out of 3213 proteins showed statistically significant deregulation in HK cells after treatment with PRGF or PRGF lyo. Gene Ontology analysis showed that these significant deregulated proteins were involved in 30 functional processes. However, the Ingenuity Pathway Analysis showed that no significant differences were found in any of the identified processes. In summary, the present study show that no significant differences were found in the proteomic profile or in the signaling pathways activation in HK cells between PRGF and PRGF lyo.
Quality of table eggs in relation to shell colour

The present study evaluated the quality of table eggs in relation to shell colour. The study was conducted on 60 table eggs with shells coloured white, green, blue and brown (15 eggs per colour) obtained from laying hens from the same backyard farm. The following external quality traits of table eggs were measured: egg weight, percentage of dirty and cracked eggs, egg width and length, egg shape index, eggshell colour, eggshell weight and percentage, and eggshell thickness. The following internal quality indicators of table eggs were determined: albumen weight and percentage, albumen pH value, albumen width, length and height, Haugh index, albumen index, yolk weight and percentage, yolk pH value, yolk width and height, yolk index and yolk colour. Green eggs had the lowest weight, as well as the lowest width and length. White eggs had the highest eggshell dirtiness scores and egg shape index, while brown eggs had the highest eggshell thickness and weight. Green and brown eggs had the highest albumen index and Haugh index. In addition, green eggs had the lowest yolk width and the highest yolk index. White eggs had the highest albumen and yolk width, the greatest albumen length and the lowest albumen height. Yolks of white and blue eggs had a higher sensory colour score, as well as lower L* and b* values compared to the yolks of green and brown eggs. Based on the results of this study, it can be concluded that green and brown table eggs are of better overall quality compared to white and blue table eggs.
Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole

Ganoderic acid A (GAA) exhibited neuron protection in in vitro epilepsy study, but no study has been done in vivo. Rats were administered (i.p.) pentylenetetrazole daily for 28 days to induce seizure. Rats with grade II or above of epileptic score were divided into three groups and given placebo, sodium valproate, or GAA treatment, respectively, for 7 days. The electrical signals of brain were monitored with electroencephalography (EGG); epileptic behavior was assessed using the Racine scale; morphological changes and apoptosis rate of cortical neurons were assessed with H&E staining and TUNEL staining, respectively. Protein expression of calcium-sensing receptor, p-ERK, p-JNK, and p-p38 in hippocampal tissue and Bcl-2, cleaved caspase-3, and Bax in cortical tissues was observed by Western blot and immunohistochemistry assay, respectively. After GAA treatment, apparent seizure-like EEG with significant arrhythmic disorder and spike waves was reduced or disappeared, and wave amplitude of EEG was reduced significantly. GAA showed similar effect with sodium valproate treatments on epilepsy. There were an apparent improvement of the epileptic behavior and a significant increase in the epileptic latency and shortening of the epileptic duration in the treatment group compared to control. GAA treatment ameliorated the nuclear pyknosis of neurons which appeared seriously in the epilepsy group. GAA treatment significantly reduced the cortical neuron apoptosis of epilepsy and the expression of calcium-sensing receptor, p-P38, p-JNK, cleaved caspase-3, and Bax but increased the expression of both p-ERK and Bcl-2. In conclusion, GAA treatment showed strong antiepileptic effect by decreasing apoptosis in cortical neuron and the expression of calcium-sensing receptor and stimulating the MAPK pathway.
Furlough and its effects on employees after returning to work: the roles of psychological contract breach and violation, and perceived organizational support

The COVID-19 pandemic brought about changes in the working world. One of the main strategies to cope with the economic situation during lockdowns was to furlough employees. In the current study, we propose that psychological contract breach and violation between the organization and the furloughed employee act as underlying mechanisms that explain the relationship between the employees' furlough status and the increase in their emotional exhaustion and decrease in affective commitment. Furthermore, we suggest that perceived organizational support can act as a buffer that attenuates the association between furloughed employment status and perceived contract breach. The study was conducted at two points in time: during the first lockdown and 4 months afterward (N = 336). Results supported the predicted indirect sequential associations. However, perceived organizational support served to buffer the relationship between furloughed employment status and perceived psychological contract breach only in the case of employees who continued to work.