Miracle-dz/UniFAR-FTUs huggingface dataset:
Advection of magnetic energy as a source of power for auroral arcs

We examine the energetics of a system wherein large‐scale magnetospheric convection causes plasma to flow across two‐dimensional sheets of field‐aligned current (FAC). This scenario requires that the FACs be held stationary or move slowly relative to the background flow, for example through their connection to conductivity enhancements in the lower ionosphere. The key result is that plasma convection across quasi‐static current sheets at speedVdimplies cross‐field transport of magnetic energy at a rate proportional toVdδB2/2μ0, where δBis the magnetic perturbation associated with the FAC. Poynting's theorem shows that this energy is available to enhance the field‐aligned component of Poynting flux, to accelerate particles via electric fields, or both. We show that, for nominal values of field‐aligned current (∼10μA/m2) and cross‐current‐sheet convection (∼100 m/s), the net field‐aligned energy flux made available through cross‐field advection can contribute of the order of 1 mW/m2to auroral energy fluxes (electromagnetic plus particle), and conceivably can dominate the energy budget in more intense arcs. While our analysis is applied to an idealized, quasi‐static, two‐dimensional system, the mechanism it illustrates could play an important role in more dynamic and highly‐structured auroral forms as well.
Diagnostic Value of the Systemic Immune-Inflammation Index in Newborns with Urinary Tract Infection

Abstract Objective Aim of this study is to investigate the diagnostic role of the systemic immune-inflammation index (SII; neutrophil × platelet [PLT]/lymphocyte) in the prediction of renal involvement in newborns with urinary tract infection (UTI). Study Design We conducted a retrospective cohort study among 117 newborns with a gestational age greater than 35 weeks and hospitalized in the NICU. Laboratory values obtained from blood samples taken before the initiation of antibiotics were evaluated for renal function tests, complete blood count, and acute phase reactants. The ratios of platelet-to-lymphocyte (PLR), neutrophil-to-lymphocyte (NLR), and SII were calculated. The patients were divided into two main groups according to the presence of urinary tract pathology in ultrasonography (US): group 1, UTI with renal involvement ( n = 43) and group 2, UTI without renal involvement ( n = 74). Predictive values of different tests were compared. Results The mean white blood cell, PLT, mean PLT volume, and neutrophile counts were higher, while lymphocyte counts were significantly lower in group 1 than those of group 2. Interleukin 6 (IL-6; pg/mL; IL-6), C-reactive protein (CRP; mg/L), NLR, PLR, and SII values were also higher in group 1. Receiver operating characteristics curve showed that SII, CRP, IL-6, PLR, and NLR have a predictive ability to discriminate renal involvement from normal renal findings in newborns with UTI. The SII produced an area under curve of 0.75 (72% sensitivity and 60.8% specificity). To define renal involvement, the cut-off values of SII, CRP, IL-6, PLR, and NLR were 217, 3.06, 23, 65.5, and 0.60, respectively. Conclusion Our results showed that SII might be used as an additional parameter in the prediction of renal involvement in newborns with UTIs. Further studies are required. Key Points Most UTIs in newborns present with upper UTI rather than simple cystitis. Some inflammatory markers can be used for the diagnosis of UTIs. SII may be useful in the prediction of urinary tract infections.
Community-based SARS-CoV-2 testing in low-income neighbourhoods in Rotterdam: Results from a pilot study

Background High incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and low testing uptake were reported in low-income neighbourhoods in Rotterdam. We aimed to improve willingness and access to testing by introducing community-based test facilities, and to evaluate the effectiveness of a rapid antigen detection test (RDT). Methods Two to eleven test facilities operated consecutively in three low-income neighbourhoods in Rotterdam, offering the options of walk-in or appointments. Background characteristics were collected at intake and one nasopharyngeal swab was taken and processed using both RDT and reverse transcription polymerase chain reaction (RT-PCR). Visitors were asked to join a survey for evaluation purposes. Results In total, 19 773 visitors were tested – 9662 (48.9%) without an appointment. Walk-in visitors were older, lived more often in the proximity of the test facilities, and reported coronavirus disease (COVID-19)-related symptoms less often than by-appointment visitors. For 67.7% of the visitors, this was the first time they got tested. A total of 1211 (6.1%) tested SARS-CoV-2-positive with RT-PCR, of whom 309 (25.5%) were asymptomatic. Test uptake increased among residents of the pilot neighbourhoods, especially in the older age groups, compared to people living in comparable neighbourhoods without community-based testing facilities. RDT detected asymptomatic individuals with 71.8% sensitivity, which was acceptable in this high prevalence setting. Visitors reported positive attitudes towards the test facilities and welcomed the easy access. Conclusions Offering community-based SARS-CoV-2 testing seems a promising approach for increasing testing uptake among specific populations in low-income neighbourhoods.
Mediating effect of reflection types: feedback on reflection-for-action and student perception of patient-centredness

ABSTRACT We aimed to examine the mediating effects of reflection on the relationship between feedback for reflection-for-action (RfA-feedback) and students’ perception of the importance of patient-centred communication (PCC) education. A survey was conducted with 358 medical students and the mediation effects were analysed by performing multiple regression analysis and Sobel test. Three types of reflection (i.e., reflection-in-action, reflection-on-action, and reflection-for-action) partially mediate the relationship between feedback for reflection-for-action, and the perceived importance of PCC education. Based on these findings, the study suggests the importance of providing feedback on reflection-for-action. Such feedback can encourage student reflection, and is crucial for their future, as medical professionals.
COSMIC EMULATION: FAST PREDICTIONS FOR THE GALAXY POWER SPECTRUM

The halo occupation distribution (HOD) approach has proven to be an effective method for modeling galaxy clustering and bias. In this approach, galaxies of a given type are probabilistically assigned to individual halos in N-body simulations. In this paper, we present a fast emulator for predicting the fully nonlinear galaxy–galaxy auto and galaxy–dark matter cross power spectrum and correlation function over a range of freely specifiable HOD modeling parameters. The emulator is constructed using results from 100 HOD models run on a large ΛCDM N-body simulation, with Gaussian Process interpolation applied to a PCA-based representation of the galaxy power spectrum. The total error is currently ∼1% in the auto correlations and ∼2% in the cross correlations from z = 1 to z = 0, over the considered parameter range. We use the emulator to investigate the accuracy of various analytic prescriptions for the galaxy power spectrum, parametric dependencies in the HOD model, and the behavior of galaxy bias as a function of HOD parameters. Additionally, we obtain fully nonlinear predictions for tangential shear correlations induced by galaxy–galaxy lensing from our galaxy–dark matter cross power spectrum emulator. All emulation products are publicly available at http://www.hep. anl.gov/cosmology/CosmicEmu/emu.html.
Investigations of a Sheet Model for a Bounded Plasma with Magnetic Field and Radiation.

A number of extensions are made to the usual one-dimensional sheet model for a plasma. The sheets, which lie in the y-z plane, are allowed to move in the x-y directions, passing freely through one another. The motion in the x direction produces the usual electrostatic field E , while the motion in the y direction produces retarded radiation fields E and B y z which are included in the calculation. A static external magnetic field in the z direction is included, and the smoothed-out stationary neutralizing backround charge density varies with x. Physical properties of this model are discussed. Expressions are derived for the synchrotron radiation from a gyrating sheet and the thermal radiation on the discrete space-time grid (used in the computer code). Dispersion properties of electromagnetic waves in the hot magnetized slab are discussed. Some peculiar aspects of the retarded radiation fields in one dimension are reconciled with the retarded fields from an extended body in three dimensions. The coupling of oscillations of the bounded slab to the field outside is discussed. A computer code has been written to follow the model in time from some initial state. Measurements are presented and discussed of sheet drag and of the spectrum of emitted radiation when the model is near equilibrium.
Pre‐test probability and likelihood ratios for clinical findings in canine leishmaniasis

Abstract Canine leishmaniasis is a parasitic zoonosis mainly caused by L. infantum; an obligate intracellular protozoan transmitted by haematophagous insects of the genus Phlebotomus, which affects dogs and wild canids. The clinical implications of this disease are highly variable, since infected animals may remain asymptomatic (absence of observable clinical signs) or present a wide spectrum of clinical alterations and degrees of severity, including the death of the animal. Symptoms such as lymphadenomegaly, alopecia, weight loss, keratoconjunctivitis and onychogryphosis are usually the first diagnostic reference available. The objectives of this study are to evaluate the validity (sensitivity, specificity and likelihood ratios) and diagnostic utility (pre‐test probability) of the clinical signs commonly associated with canine leishmaniasis based on the prevalence in the area and to explore the combination of symptoms that best predicts the diagnosis of canine leishmaniasis. It is a matched case‐control study in the canine population of southern Spain based on the comparison of the findings collected in the clinical history and the results of the LeisSCAN quantitative ELISA. A total of 39 cases and 78 controls were analysed. Approximately 80% of the infected animals showed signs compatible with the disease. The most frequent alterations were cutaneous (64.1%), systemic (51.3%) and oculo‐nasal (30.7%). The most useful signs to support this diagnosis were alopecia and epistaxis (LR+ 6.69 and 6.0, respectively) (pre‐test leishmaniasis probability is ≥70% for prevalence ≥28% when alopecia or epistaxis is present), followed by lameness (LR+ 5.0). The combinations of signs that showed greater validity were alopecia with hyperkeratosis of the snout and alopecia with onychogryphosis (LR+ > 10). None of the observed signs or their combinations resulted useful to rule out the diagnosis (LR– 0.55 to 1.15). The results found show notable differences in the diagnostic value of the clinical signs, individually and in combination, so we believe that medical decisions should be based on their diagnostic validity (LR+) and the estimation of the pre‐test and post‐test probability.
Tuning the electronic structure of monolayer graphene/ Mo S 2 van der Waals heterostructures via interlayer twist

We directly measure the electronic structure of twisted graphene/MoS2 van der Waals heterostructures, in which both graphene and MoS2 are monolayers. We use cathode lens microscopy and microprobe angle-resolved photoemission spectroscopy measurements to image the surface, determine twist angle, and map the electronic structure of these artificial heterostructures. For monolayer graphene on monolayer MoS2, the resulting band structure reveals the absence of hybridization between the graphene and MoS2 electronic states. Further, the graphene-derived electronic structure in the heterostructures remains intact, irrespective of the twist angle between the two materials. In contrast, however, the electronic structure associated with the MoS2 layer is found to be twist-angle dependent; in particular, the relative difference in the energy of the valence band maximum at {\Gamma} and K of the MoS2 layer varies from approximately 0 to 0.2 eV. Our results suggest that monolayer MoS2 within the heterostructure becomes predominantly an indirect bandgap system for all twist angles except in the proximity of 30 degrees. This result enables potential bandgap engineering in van der Waals heterostructures comprised of monolayer structures.
Hepatology in space: Effects of spaceflight and simulated microgravity on the liver

Microgravity as experienced during spaceflight affects a number of physiological processes in various organs. However, effects on the liver have yet been poorly documented. Nevertheless, the liver is a metabolically highly active organ involved in carbohydrate metabolism, lipid metabolism and xenobiotic biotransformation. The present paper provides an overview of the effects of microgravity on the liver observed in experimental animals during actual spaceflight and upon simulation of microgravity on Earth. These include (i) induction of liver injury and inflammation associated with apoptosis and oxidative stress, (ii) changes in liver carbohydrate metabolism resulting in the onset of a diabetogenic phenotype, (iii) modifications in hepatic lipid metabolism leading to early non‐alcoholic fatty liver disease and (iv) alterations of the hepatic xenobiotic biotransformation machinery. Although most of these observations remain to be fully validated in humans, appropriate measures to counteract liver pathogenesis should be considered, especially in view of long‐term space missions.
Holomorphic Function Theory in Several Variables: An Introduction

Elementary local properties of holomorphic functions of several complex variables. - Currents and complex structures. - The Bochner-Martinelli-Koppelman kernel and formula applications. - Extensions of CR functions. - Extensions of holomorphic and CR functions on manifolds. - Domains of holomorphy and pseudoconvexity. - The Levi problem and the resolution of iua in strictly pseudoconvex domains. - Characterisation of removable singularities of CR functions on a strictly pseudoconvex boundary. - Appendices.
Dark matter in disc galaxies - I. A Markov Chain Monte Carlo method and application to DDO 154

We present a new method to constrain the dark matter halo density profiles of disk galaxies. Our algorithm employs a Markov Chain Monte Carlo (MCMC) approach to explore the parameter space of a general family of dark matter profiles. We improve upon previous analyses by considering a wider range of halo profiles and by explicitly identifying cases in which the data are insufficient to break the degeneracies between the model parameters. We demonstrate the robustness of our algorithm using artificial data sets and show that reliable estimates of the halo density profile can be obtained from data of comparable quality to those currently available for low surface brightness (LSB) galaxies. We present our results in terms of physical quantities which are constrained by the data, and find that the logarithmic slope of the halo density profile at the radius of the innermost data point of a measured rotation curve can be strongly constrained in LSB ([Vstar/Vobs]max ~ 0.16) galaxies. High surface brightness galaxies ([Vstar/Vobs]max ~ 0.79) require additional information on the mass-to-light ratio of the stellar population - our approach naturally identifies those galaxies for which this is necessary. We apply our method to observed data for the dwarf irregular galaxy DDO 154 and recover a logarithmic halo slope of -0.39 +- 0.11 at a radius of 0.14 kpc. Our analysis validates earlier estimates which were based on the fitting of a limited set of individual halo models, but constitutes a more robust constraint than was possible using other techniques since it marginalises over a wide range of halo profiles.
Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca2+ signalling in heart failure

Mitochondrial dysfunction in cardiomyocytes is a hallmark of heart failure development. Although initial studies recognized the importance of different mitochondrial subpopulations, there is a striking lack of direct comparison of intrafibrillar (IF) versus perinuclear (PN) mitochondria during the development of HF. Here, we use multiple approaches to examine the morphology and functional properties of IF versus PN mitochondria in pressure overload-induced cardiac remodelling in mice, and in non-failing and failing human cardiomyocytes. We demonstrate that PN mitochondria from failing cardiomyocytes are more susceptible to depolarization of mitochondrial membrane potential, reactive oxygen species generation and impairment in Ca2+ uptake compared with IF mitochondria at baseline and under physiological stress protocol. We also demonstrate, for the first time to our knowledge, that under normal conditions PN mitochondrial Ca2+ uptake shapes nucleoplasmic Ca2+ transients (CaTs) and limits nucleoplasmic Ca2+ loading. The loss of PN mitochondrial Ca2+ buffering capacity translates into increased nucleoplasmic CaTs and may explain disproportionate rise in nucleoplasmic [Ca2+] in failing cardiomyocytes at increased stimulation frequencies. Therefore, a previously unidentified benefit of restoring the mitochondrial Ca2+ uptake may be normalization of nuclear Ca2+ signalling and alleviation of altered excitation–transcription, which could be an important therapeutic approach to prevent adverse cardiac remodelling. This article is part of the theme issue ‘The cardiomyocyte: new revelations on the interplay between architecture and function in growth, health, and disease’.
CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells

Abstract Background/Aim: The development of pharmacological inhibitors targeting negative regulators of p53, such as murine double minute (MDM) 2 and, more recently, MDM4, has been actively pursued as a potential strategy to treat cancers with wild-type p53. We previously showed that CEP-1347, a small molecule kinase inhibitor originally developed for the treatment of Parkinson’s disease, suppressed MDM4 expression and activated wild-type p53 in retinoblastoma cells. However, it remains unknown whether CEP-1347 acts as an MDM4 inhibitor and as such activates p53 in other types of human cancer cells. Materials and Methods: The effects of CEP-1347 and MDM4 knockdown on the mRNA and protein expression of components of the p53 pathway, including MDM4, in human glioma cell lines with and without p53 mutation were examined by RT-PCR and western blot analyses. Trypan blue dye exclusion was used to examine the effect of CEP-1347 on cell growth. Results: CEP-1347 decreased the expression of MDM4, increase that of p53, and activated the p53 pathway in glioma cells with wild-type p53. Knockdown-mediated inhibition of MDM4 expression in a glioma cell line with wild-type p53 that overexpresses MDM4 resulted in increased p53 expression and activation of the p53 pathway. CEP-1347 preferentially inhibited the growth of glioma cells with wild-type p53 without showing toxicity to normal cells at clinically relevant concentrations. Conclusion: Our findings suggest CEP-1347 is a novel inhibitor of MDM4 protein expression and as such activates p53 to inhibit the growth of cancer cells with wild-type p53, including retinoblastoma and glioblastoma.
Waning of vaccine effectiveness against moderate and severe covid-19 among adults in the US from the VISION network: test negative, case-control study

Abstract Objective To estimate the effectiveness of mRNA vaccines against moderate and severe covid-19 in adults by time since second, third, or fourth doses, and by age and immunocompromised status. Design Test negative case-control study. Setting Hospitals, emergency departments, and urgent care clinics in 10 US states, 17 January 2021 to 12 July 2022. Participants 893 461 adults (≥18 years) admitted to one of 261 hospitals or to one of 272 emergency department or 119 urgent care centers for covid-like illness tested for SARS-CoV-2. Main outcome measures The main outcome was waning of vaccine effectiveness with BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) vaccine during the omicron and delta periods, and the period before delta was dominant using logistic regression conditioned on calendar week and geographic area while adjusting for age, race, ethnicity, local virus circulation, immunocompromised status, and likelihood of being vaccinated. Results 45 903 people admitted to hospital with covid-19 (cases) were compared with 213 103 people with covid-like illness who tested negative for SARS-CoV-2 (controls), and 103 287 people admitted to emergency department or urgent care with covid-19 (cases) were compared with 531 168 people with covid-like illness who tested negative for SARS-CoV-2. In the omicron period, vaccine effectiveness against covid-19 requiring admission to hospital was 89% (95% confidence interval 88% to 90%) within two months after dose 3 but waned to 66% (63% to 68%) by four to five months. Vaccine effectiveness of three doses against emergency department or urgent care visits was 83% (82% to 84%) initially but waned to 46% (44% to 49%) by four to five months. Waning was evident in all subgroups, including young adults and individuals who were not immunocompromised; although waning was morein people who were immunocompromised. Vaccine effectiveness increased among most groups after a fourth dose in whom this booster was recommended. Conclusions Effectiveness of mRNA vaccines against moderate and severe covid-19 waned with time after vaccination. The findings support recommendations for a booster dose after a primary series and consideration of additional booster doses.
PLANETS ON THE EDGE

Hot Jupiters formed through circularization of high-eccentricity orbits should be found at orbital separations a exceeding twice that of their Roche limit aR. Nevertheless, about a dozen giant planets have now been found well within this limit (aR < a < 2 aR), with one coming as close as 1.2 aR. In this Letter, we show that orbital decay (starting beyond 2 aR) driven by tidal dissipation in the star can naturally explain these objects. For a few systems (WASP-4 and 19), this explanation requires the linear reduction in convective tidal dissipation proposed originally by Zahn and verified by recent numerical simulations, but rules out the quadratic prescription proposed by Goldreich & Nicholson. Additionally, we find that WASP-19-like systems could potentially provide direct empirical constraints on tidal dissipation, as we could soon be able to measure their orbital decay through high precision transit timing measurements.