Miracle-dz/UniFAR-FTUs huggingface dataset:
Translocation of Helicobacter hepaticus synergizes with myeloid-derived suppressor cells and contributes to breast carcinogenesis

ABSTRACT Microbial dysbiosis plays an important role in the development of intestinal diseases. Recent studies suggest a link between intestinal bacteria and mammary cancer. Here, we report that female ApcMin/+ mice infected with Helicobacter hepaticus exhibited an increased mammary and small/large intestine tumor burden compared with uninfected littermates. H. hepaticus DNA was detected in small/large intestine, mammary tumors, and adjacent lymph nodes, suggesting a migration pathway. CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs) infiltrated and expressed high levels of Wnts, likely enhancing tumorigenesis through activation of Wnt/β-catenin pathway. Our previous studies indicated that histidine decarboxylase (Hdc) marks a population of myeloid-biased hematopoietic stem cells and granulocytic MDSCs. Cytokines/chemokines secreted by IL-17-expressing mast cells and tumor tissues promoted Hdc+ MDSCs expansion and trafficking toward mammary tumors. Adoptive transfer of MDSCs isolated from H. hepaticus-infected mice increased MDSCs frequencies in peripheral blood, mesenteric lymph nodes, mammary gland, and lymph nodes in recipient ApcMin/+ mice. The adoptive transfer of H. hepaticus primed MDSCs also increased the size and number of mammary tumors. Our results demonstrate that H. hepaticus can translocate from the intestine to mammary tissues to promote mammary tumorigenesis with MDSCs. Targeting bacteria and MDSCs may be useful for the prevention and therapy of extraintestinal cancers. Abbreviations: Helicobacter hepaticus, Hh; myeloid-derived suppressor cell, MDSC; histidine decarboxylase, Hdc; Breast cancer, BC; T regulatory, TR; inflammatory bowel disease, IBD; fluorescence in situ hybridization, FISH; myeloid-biased hematopoietic stem cells, MB-HSCs; granulocytic MDSCs, PMN-MDSCs; Lipopolysaccharide, LPS; Toll-like receptors, TLRs; Mast cells, MCs; Granulocyte-macrophage colony-stimulating factor, GM-CSF; epithelial–mesenchymal transition, EMT; Intestinal epithelial cells, IECs.
Türk lirasının dönemler arası itibarı: Karşılaştırmalı ARDL sınır testi yaklaşımları

24 Ocak 1980 kararları ile Türkiye ekonomisinde başlayan serbestleşme hareketleri Türk lirasının 4.4. 1990 tarihinde konvertibilite kazanmasının yolunu açmıştır. Ancak iktisadi, siyasi ve toplumsal açıdan bir dönüm noktası olan 2001 Şubat krizine kadar sürekli değişen koalisyon hükümetleri, ekonomik krizler, depremler ve sıra dışı olaylar nedeniyle konvertibilitenin olumlu etkileri Türkiye ekonomisine yansımamıştır. Bu nedenle zaman zaman konvertibilite ilanının zamanlaması eleştirilmiştir. 2001 krizinin etkilerinin 2002 yılı başlarında geçmeye başlaması ve 3 Kasım 2002’den sonra siyasi istikrarın ekonomik istikrara dönüşmesinden dolayı Türk lirası güçlenmiş ve konvertibilite daha anlamlı hale gelmiştir. Bu çalışma; 1987:2-2001:4 ve 2002:1-2019:2 dönemleri için kurulan iki model yardımıyla Türkiye’de bankalarda tutulan yabancı mevduatın toplam mevduatlar içindeki payının bir önceki döneme göre değişim hızı ile temsil edilen Türk lirasının itibarı ve talebi ve seçilmiş makroekonomik değişkenler arasındaki ilişkileri Autoregressive Distributed Lag Modeli ve Error Correction Model ile incelemekte ve karşılaştırmaktadır. Yapılan ampirik analizlerden çıkan anlamlı sonuçlara göre; 1987:2-2001:4 ve 2002:1-2019:2 dönemlerinde Türkiye’de bankalarda tutulan yabancı mevduatın toplam mevduatlar içindeki payının bir önceki döneme göre değişim hızını etkileyen iktisadi kriz yaşanma sıklığı, seçilmiş makroekonomik değişkenler ve değişkenlerin etki yönleri hem kısa hem de uzun dönemde farklılık göstermektedir.
Analysis of online learning process during the Covid-19 Pandemic in primary school teachers

This study aims to described the analysis of difficulties and efforts of teachers in online learning at SDN Airlangga III/200 Surabaya. This research uses qualitative descriptive method research, information collection method using online observation, interview, and documentation. The data analysis method used in this study is data reduction, data presentation and conclusion drawing. Researchers act as data collection instruments. The results showed that the difficulties that teachers felt in online learning during the Covid-19 Pandemic were insufficient facilities, material completion and assessment. The efforts that teachers try to overcome the difficulties felt is by sharing supporting internet access, various assignments, as well as cooperation with the school, teachers and parents of students. The impact obtained after efforts to improve online learning problems is a significant transformation in online learning during the Covid-19 Pandemic grade IV SDN Airlangga III/200 Surabaya.
Paratransit services under normal and emergency conditions using public transport resources

Στην παρούσα διδακτορική διατριβή διερευνώνται υπηρεσίες μεταφοράς επιβατών με ειδικές απαιτήσεις με τη χρήση μέσων μαζικής μεταφοράς υπό κανονικές και έκτακτες συνθήκες. Συγκεκριμένα, η παρούσα διατριβή αρχικά επικεντρώνεται στον σχεδιασμό εξατομικευμένων μεταφορικών υπηρεσιών με τη χρήση μέσων μαζικής μεταφοράς, και συγκεκριμένα του δημόσιου συστήματος λεωφορείων. Επιπλέον, εξετάζεται πως οι σχετικές υπηρεσίες δύνανται να βελτιωθούν ενισχύοντας το σύστημα λεωφορείων με μισθωμένα οχήματα. Οι εν λόγω υπηρεσίες έχουν στόχο την παροχή κινητικότητας υψηλής ποιότητας σε άτομα που χρήζουν ειδικών συνθηκών μεταφοράς, ενώ λαμβάνεται υπόψη και το σχετικό κόστος. Για τη μελέτη αυτών των συστημάτων ορίστηκαν νέα προβλήματα προγραμματισμού δρομολογίων, τα οποίο διατυπώθηκαν ως προβλήματα μεικτού γραμμικού ακεραίου προγραμματισμού και επιλύθηκαν με νέες μεθόδους Κλάδου και Αποτίμησης (ΚΑ). Επίσης, διεξήχθηκαν εκτεταμένες πειραματική μελέτες για το κάθε σύστημα με τη βοήθεια των αντιστοίχων μεθόδων ΚΑ για την μελέτη της επίδρασης των βασικών παραμέτρων των συστημάτων στην ποιότητα εξυπηρέτησης. Επίσης, στην παρούσα διατριβή διερευνώνται περιπτώσεις εκκενώσεων περιοχών εν όψει εκτάκτων καταστάσεων. Για την περίπτωση αυτή, διερευνούμε το πρόβλημα του προγραμματισμού εκκένωσης περιοχών με τη χρήση υφιστάμενων δημόσιων συστημάτων λεωφορείων, λαμβάνοντας υπόψη σημαντικούς περιορισμούς που σχετίζονται με τη δυναμικότητα των διαθέσιμων καταφυγίων. Επιπροσθέτως, διερευνούμε επέκταση του παραπάνω προβλήματος, η οποία αφορά τη μεταφορά τραυματιών σε νοσοκομειακές μονάδες, είτε μόνιμες και μεγάλης δυναμικότητας είτε προσωρινές και μικρής δυναμικότητας. Για την επίλυση των προβλημάτων εκκένωσης αναπτύξαμε ένα πλαίσιο επίλυσης δύο φάσεων, το οποίο συνδυάζει κατάλληλα γνωστές ευρετικές και ακριβείς μεθόδους. Η πειραματική διερεύνηση σχετικά με τα προβλήματα εκκένωσης αφορούσε την αξιολόγηση του προτεινόμενου υβριδικού πλαισίου Αρχικά, επικυρώθηκε η ποιότητα των λύσεων που παράγονται από το υβριδικό πλαίσιο συγκρίνοντάς τες με τις βέλτιστες λύσεις που παράγονται από την επίλυση του μαθηματικού μοντέλου για προβλήματα μικρής κλίμακας. Τέλος, εκμεταλλευόμενοι μερικά από τα σημαντικά χαρακτηριστικά των παραπάνω προβλημάτων, καθώς και των μεθόδων επίλυσης που αναπτύχθηκαν για αυτά, μελετήσαμε ειδικές περιπτώσεις στον τομέα των logistics. Οι ειδικές περιπτώσεις του τομέα των logistics που μελετήθηκαν αφορούν τη δρομολόγηση ενός οχήματος και δύο σημείων αναπλήρωσης του αποθέματος του οχήματος.
Responsive to whom? Political advising and elected careers in institutionalized democracies

Political advising is an increasingly important stepping-stone for a parliamentary career in many advanced democracies. Not only does this trend inform our understanding of political parties and careers, there is reason to think former advisors may have distinct attitudes compared to other types of elected officials. Using elite survey data from 42 elections in 21 countries, this study asks whether former political advisers approach representation differently than candidates with other pre-legislative experience. We find that they do. In particular, former advisors are more willing to prioritize their party’s preferences over their constituents’ preferences, and favor their own convictions over their constituents’ priorities. These findings demonstrate that former advisors have a more party-centric approach to representation, consistent with the “loyal partisan” archetype. The results inform our understanding of an increasingly common pathway to elected office as well as the personalization and professionalization of politics and have important implications for representative democracy.
Determination of Death Anxiety and Death-Related Depression Levels in the Elderly During the COVID-19 Pandemic

The aim of the study is to determine the levels of death anxiety and death-related depression in the elderly during the COVID-19 pandemic. The sample of the descriptive-relational study includes 344 elderly people registered in a family health center. It was determined that the most dreaded fear reported by the elderly who got COVID-19 infection was death, and there was a highly significant positive correlation between death anxiety and death-related depression ratings of the elderly and that as the average death anxiety score of the elderly rises, so does the degree of death-related depression.
ANALISIS HUBUNGAN KARAKTERISTIK KEPALA KELUARGA DENGAN PERILAKU PENCEGAHAN DEMAM BERDARAH DI PAKIJANGAN BREBES

Penelitian ini bertujuan untuk mengetahui hubungan karakteristik kepala keluarga dengan perilaku pencegahan DBD kepala keluarga di Desa Pakijangan Kecamatan Bulakamba Kabupaten Brebes Tahun 2014. Populasi dalam peneltian ini adalah kepala keluarga (KK) Desa Pakijangan dengan sampel sebanyak 98 kepala keluarga. Data dikumpulkan melalui wawancara dengan pengambilan sampel menggunakan multistage sampling, yaitu teknik stratified proportional sampling dengan RW sebagai strata dan accidental sampling untuk pengambilan KK di tiap RW. Hasil penelitian menunjukkan bahwa sebagian besar kepala keluarga telah melaksanakan pencegahan DBD dengan baik (51 %) dengan karakteristik kepala keluarga mayoritas berpendidikan ≤ SMP (65,7 %), berumur > 36 tahun (60,2 %), bekerja (76,5 %), dan berjenis kelamin laki-laki (73,5 %). Tetapi hasil penelitian menunjukkan tidak ada hubungan antara karakteristik kepala keluarga meliputi pendidikan (pvalue: 0,126); pekerjaan (pvalue: 0,189); umur (pvalue: 0,457) dan jenis kelamin (pvalue: 0,736) dengan perilaku dalam pencegahan DBD. Hal ini kemungkinan karena masing-masing karakteristik berhubungan dengan faktor-faktor lain dalam mempengaruhi perilaku pencegahan DBD, seperti keterpaparan kepala keluarga dengan media komunikasi, jenis pekerjaaan kepala keluarga, dan lain-lain. Kata Kunci: karakteristik, perilaku, pencegahan, DBD
Selective Enrichment Method for Isolation of Efficient Phosphate Solubilizing Bacteria from Soil

ABSTRACT Isolation and screening of phosphate solubilizing bacteria (PSB) seems to become cumbersome using conventional methods, and there may be a chance to lose the more potent isolates during the screening methodology. To overcome these problems, a selective enrichment method has been developed to isolate and screen efficient PSB from diverse sources. Initially, this method includes enrichment of the phosphate solubilizers in the sample followed by selective isolation and screening. Looking into the physico-chemical data, it was revealed that the soil samples from cultivated soil were found to support growth and development of microbial life in general compared to soil samples from non-cultivated stringent environment, which was reflected in number of PSB isolated, or in some samples, PSB may not be obtained. Here, the selective enrichment method developed for isolation of PSB from stringent environmental samples yielded numerically higher number (14) of phosphate solubilizer isolates in comparison to conventional methods (4) from different soil sources. Moreover, isolates obtained following selective enrichment were found consistence for phosphate solubilization in different conditions and for different sources. In contrast to conventional isolation methodologies, the selective enrichment method consistently performed best for PSB isolation particularly from stringent habitats, i.e. mining region where conventional method/s did not perform well.
Application of Several Models for the Forecasting of the Container Throughput of the Abidjan Port in Ivory Coast

The Abidjan Port in Ivory Coast has the second highest volume of Container Throughput in West Africa and aims to become a hub Port for the region and one of the most developed Port in Africa in the coming years. In this article, several Forecasting Models are applied to accurately forecast the Abidjan Port Container Throughput. These models are the Grey model, the Linear Regression model, the Double Exponential Smoothing model and a Combination Forecast model. After the application of each model, their results have been compared with the mean absolute percentage error. From their results, the Double Exponential Smoothing model has got the smallest error and been found to have the best data available on the research work, becoming at the same time, the best forecasting model for the Abidjan Port Container Throughput. A forecast of the Abidjan Port Container Throughput was finally made for the period covering the year 2015 up to the year 2020.
Radar target identification based on adaptive joint time-frequency processing in high frequency domain

A new radar target feature extraction method based on adaptive joint time-frequency processing is presented for radar target recognition in the high frequency domain. After applying the adaptive Gaussian representation to the range profile, some of the decomposing parameters are extracted as feature vectors used for identification. Comparing with range profiles, the extracted feature vectors proposed by this method increase the identification information and decrease the computation and storing burden significantly when compared to the adaptive spectrogram. The physical meaning is also more definite. This method is used for identifying six kinds of aircraft scale models. The experiment results show that the new feature extraction method is practical.
Aplikasi Linier Ukuran Tubuh untuk Seleksi Fenotipik Bibit Induk Sapi PO di Kabupaten Bojonegoro

The objective of this research was to predict body weight of Peranakan Ongole (PO) cattle using simple linear body measurement. The height wither (HW), body length (BL), heart girth (HG) and chest widht (CW) were measured in centimeters, using caliper, whereas weaning (WW) and yearling weight (YW) was determined in kilograms using a weighing scale. Results of the correlation coefficient showed that hearth girth (HG) highly correlated with body weight was 0.99. In all, the body lenght (HW) had the least correlation coefficient was 0.30 on body weight. Results of the stepwise regression showed that HG was a good estimator of body weight PO cattle. The comparison of residuals indicated that only two equations accurately predicted body weight. From these results, it was concluded that body weight of Female PO cattle can be estimated using simple linear body measurement of heart girth especially in most remote areas where farmers are challenged with the unavailability of weighing scale
DESIGN OF CONCRETE AIRPORT PAVEMENT

Procedures given for design and evaluation of concrete airport f pavements. Design topics include: subgrades and subbases; slab thickness; plain, reinforced, and continuously reinforced pavement; joint design; and I concrete overlays. Special design topics include a fatigue analysis for mixed I I aircraft loads, determination of pavement stiffness for heavy-duty pavements, I and use of computer program and influence charts. I I REFERENCE: Design of Concrete Airport Pavement (EB050.03P), Portland 1 Cement Association, 1973. I I I I Microcomputer Program for Concrete Thickness Design for Airport and Industrial Pavements This software package makes it easy to accurately compute the flexural stresses in a concrete pavement induced by wheel loads of aircraft and industrial vehicles. The use of these computed stresses in pavement design and evaluation follows the methods outlined in this manual. The microcomputer program is a conversion of PCA's mainframe program, PDILB, described in Appendix C of this manual. The program has gained international recognition for the evaluation of both aircraft loadings and pavement strength. For example, in 1981 the International Civil Aviation Organization (ICAO) adopted for worldwide use the PCA computer program as the single method for evaluating aircraft loads on concrete pavements. Aircraft manufacturers, for each commercial aircraft, publish the document entitled "Aircraft Characteristics," which includes in the section on rigid pavement requirements the Portland Cement Association method (Computer Program for Airport Pavement Design). Aircraft manufacturers use the program to study the effects in landing-gear design of adding more wheels, changing wheel spacings, and accounting for tire pressure effects. The program will work with the IBM family of personal computers and true compatibles with minimum 128 KB RAM memory and MS-DOS 2.1 1 or PC DOS 2.1 or later version of these. Software package includes floppy disk, User's Manual, binder, slipcase, and a listing of aircraft load data for many commercial aircraft. To order AIRPORT (Code No. MC006) call or write: Portland Cement Association Order Processing 5420 Old Orchard Road Skokie, IL 60077-1083 Telephone: (708) 966-6200 After 1/96, (847) 966-6200 PORTLAND CEMENT ASSOCIATION An organization of cement manufacturers lo improve and extend the uses of portland cement and concrete through market development, engineering, research. education, and public affairs work. Printed in U.S.A. 5420 Old Orchard Road, Skokie, Illinois 60077-1 083
Thinner Central Corneal Thickness is Associated with a Decreased Parapapillary Vessel Density in Normal Tension Glaucoma

This retrospective cross-sectional study, which enrolled 124 normal tension glaucoma (NTG) eyes and 68 healthy eyes as the control, determined the association between central corneal thickness (CCT) and ocular parameters in NTG. CCT was measured using the Pentacam® system, optical coherence tomography angiography (OCT-A) was adopted to measure the peripapillary and macular area VDs, and spatial data were based on the Garway–Heath map as illustrated in OCT-A. Univariate and multivariate linear regressions were used to statistically analyze for associations between CCT and other factors. In this study, the mean age was similar for both the NTG and control groups. The mean CCT of the NTG group was significantly thinner than that of the control group (533.97 ± 33.11 µm vs. 546.78 ± 38.21 µm; p = .022). Considering all the factors, CCT negatively correlated with visual field (VF) pattern standard deviation (univariate, p = .045). To analyze structural and functional factors separately, we found a significant positive correlation between CCT and whole disc radial peripapillary capillary VD (VDRPC; multivariate, p = .019). To analyze the relationship between all factors and sectoral changes in VDRPC, a significant positive correlation was observed between CCT and inferior temporal VDRPC (univariate, p = .039) and inferior nasal VDRPC (VDRPC IN; univariate, p = .048). In conclusion, this novel study shows that among NTG participants, a thinner cornea correlated with weaker biomechanical properties susceptible to optic nerve tissue displacement, especially in response to mild transient elevation of IOP, leads to compromised ocular microcirculation.
Consonantalized Nasal and Lateral Vowel /ə/ Versus Nasal and Lateral Syllabic Consonants

The present paper aims, firstly, to investigate the phonological change that takes place to the unstressed vowel in the closed syllable CVC without onset + /ə/ + (lateral/nasal consonant). In this regard, I will explain the distinctive feature of /ə/, /l/ and /n/ as actual phonemes, and describe their distinctive feature in phonological patterns expressed by the syllable structure rule CVC, regardless of onset. In other words, the research focus will be on the rhyme of the CVC, where V stands for /ə/ and C stands either for /l/ or /n/. Secondly, I will demonstrate the cause of the phonological change that occurs in the rhyme of the syllable. Thirdly, I intend to establish which phoneme has power over the other phoneme in the rhyme of syllable CVC (/ə/+/l/or /n/). Fourthly, I will construct a proper definition for the rhyme of the syllable involving the phonological change occurring to the unstressed vowel in this rhyme. The most important results are: firstly, /ə/ is assimilated (consonantalized) by lateral and nasalized features within the rhyme context (-/ə/ +/n/ or -/ə/+/l/), secondly, there is no evidence for the elision of /ə/ in the same phonological context. The term consonantalization is proposed as a result of similarities between /ə/, /n/ and //ə/ and /l/ in the rhyme of syllable CVC (/ə/+/l/or /n/).
Civil Engineering students’ response to visualisation learning experience with building information model

Abstract The paper presents a study of Civil Engineering students’ responses to a questionnaire on their visualisation learning experience with Building Information Modelling (BIM). Fourth-year undergraduate students of the Civil Engineering Course at Curtin University, Perth, Western Australia, were participants of the survey. BIM was introduced and incorporated into two subjects (called Units hereafter), namely Construction Technology (CT), and Integrated Design and Construction (IDC). Training was provided to students on the use of the modelling tool, structural engineering software, construction scheduling and simulation software, and how to transfer files in a BIM environment. In the CT Unit, the use of BIM tools was demonstrated through worked examples and students were given assessment tasks to create a model, perform structural analysis and design, and produce construction scheduling and simulation. In the IDC Unit, the assessment task contained a larger scope requiring a more collaborative approach and roles changing to simulate the complete process of the design, tender and construction phases of a project; however, the use of BIM tools was optional. Details of the work tasks given in the Units and the learning outcomes will be presented. The results from the questionnaire survey show that students were very enthusiastic and agreed that learning BIM technology would benefit them, with many respondents indicating they preferred to start learning from as early as in their first year. This outcome enforces the much-needed paradigm shift in teaching and learning from being traditional to more technology-based learning.