Miracle-dz/UniFAR-FTUs huggingface dataset:
Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model

Introduction The blood–brain barrier (BBB) is a key obstacle to the delivery of drugs into the brain. Therefore, it is essential to develop an advanced drug delivery nanoplatform to solve this problem. We previously screened a small rabies virus glycoprotein 15 (RVG15) peptide with 15 amino acids and observed that most of the RVG15-modified nanoparticles entered the brain within 1 h of administration. The high BBB penetrability gives RVG15 great potential for brain-targeted drug delivery systems. Moreover, a multifunctional integrated nanoplatform with a high drug-loading capacity, tunable functionality, and controlled drug release is crucial for tumor treatment. Zeolitic imidazolate framework (ZIF-8) is a promising nanodrug delivery system. Methods Inspired by the biomimetic concept, we designed RVG15-coated biomimetic ZIF-8 nanoparticles (RVG15-PEG@DTX@ZIF-8) for docetaxel (DTX) delivery to achieve efficient glioblastoma elimination in mice. This bionic nanotherapeutic system was prepared by one-pot encapsulation, followed by coating with RVG15-PEG conjugates. The size, morphology, stability, drug-loading capacity, and release of RVG15-PEG@DTX@ZIF-8 were thoroughly investigated. Additionally, we performed in vitro evaluation, cell uptake capacity, BBB penetration, and anti-migratory ability. We also conducted an in vivo evaluation of the biodistribution and anti-glioma efficacy of this bionic nanotherapeutic system in a mouse mode. Results In vitro studies showed that, this bionic nanotherapeutic system exhibited excellent targeting efficiency and safety in HBMECs and C6 cells and high efficiency in crossing the BBB. Furthermore, the nanoparticles cause rapid DTX accumulation in the brain, allowing deeper penetration into glioma tumors. In vivo antitumor assay results indicated that RVG15-PEG@DTX@ZIF-8 significantly inhibited glioma growth and metastasis, thereby improving the survival of tumor-bearing mice. Conclusion Our study demonstrates that our bionic nanotherapeutic system using RVG15 peptides is a promising and powerful tool for crossing the BBB and treating glioblastoma.
Scaling laws of femtosecond laser pulse induced breakdown in oxide films

The scaling of the single-pulse laser threshold fluence for dielectric breakdown with respect to pulse duration and material band gap energy was investigated in the subpicosecond pulse regime using oxide films (${\mathrm{TiO}}_{2}$, ${\mathrm{Ta}}_{2}{\mathrm{O}}_{5}$, ${\mathrm{HfO}}_{2}$, ${\mathrm{Al}}_{2}{\mathrm{O}}_{3}$, and ${\mathrm{SiO}}_{2}$). A phenomenological model attributes the pulse duration dependence to the interplay of multiphoton ionization, impact ionization, and subpicosecond electron decay out of the conduction band. The observed linear scaling of the breakdown fluence with band gap energy can be explained within the framework of this model by invoking the band gap dependence of the multiphoton absorption coefficient from Keldysh photoionization theory. The power exponent $\ensuremath{\kappa}$ of the observed dependence of the breakdown threshold fluence ${F}_{\mathit{th}}$ on pulse duration ${\ensuremath{\tau}}_{p}$, ${F}_{\mathit{th}}\ensuremath{\propto}{\ensuremath{\tau}}_{p}^{\ensuremath{\kappa}}$, is independent of the material and is attributed to photoionization seeded avalanche ionization.
The T Tauri spectroscopic binary GW Orionis

The classical T Tauri star GW Ori is found to be a spectroscopic binary whose orbital period is 242 days. Radial velocity data are presented which show that GW Ori is a velocity variable, the spectroscopic orbital elements are listed, and the dynamic masses for secondary and primary/secondary separations at different inclination angles are given. Two theoretical models for the spectral energy distribution are considered in detail, based on the binary's flux distribution which is double peaked with a strong silicate emission. The pure-disk model, consisting of a primary star, both a circumprimary and circumbinary disk, and optically thin hot dust between the disks, is found to fit the spectral distribution with the exception of higher luminosity in the 13-18 micron range. A disk-shell model is also considered in which an optically thin shell replaces the circumbinary disk. This model fits the spectral distribution well although the visual extinction must be larger than the observed A(v). The significance of the circular orbit theorized for the binary is considered with special attention given to the disk-induced excitation of eccentricity in binary orbits. 53 refs.
Emergence of a subordinate construction in a sign language: Intonation ploughs the field for morphosyntax

A central question in historical linguistics is how subordination emerges. Many linguists have hypothesized that diachronically subordinate constructions start off with intonational signals, and that these precede morphosyntactic markers of subordination (Givón 2012; Mithun 2009 inter alia ). Contemporary spoken languages cannot provide a testing ground for this hypothesis because all of them have fully grammaticalized subordinate constructions. However, a young sign language, such as Israeli Sign Language (ISL), is perfectly suited for this purpose (Meir and Sandler 2008). In ISL, relative clauses are usually marked by squinted eyes and a forward head position, which have been shown to perform the functions of intonation (Sandler 1999; Dachkovsky, Healy and Sandler 2013), as well as by a manual demonstrative form appearing at the relative clause boundary. Yet, consistent marking of relative clauses in the language is characteristic of the younger signers’ but not of the older signers’ language. This suggests that relative clause marking developed over time in the language, which leads us to ask how it emerged and developed. The present study tracks the emergence of the relative clause (RC) construction by investigating changes in intonational and morphosyntactic signals across three generations of ISL signers. The study demonstrates that these signals begin as pragmatic or, more specifically, as information structuring devices, and are transformed by a grammaticalization process into RC markers. Furthermore, we show that intonational cues in the newly emerging RCs pave the way for a morphosyntactic marker.
Photometry and Spectroscopy of the Type IIP SN 1999em from Outburst to Dust Formation

We present photometry and spectra of the Type IIP supernova 1999em in NGC 1637 from several days after the outburst till day 642. The radioactive tail of the recovered bolometric light curve of SN 1999em indicates that the amount of the ejected 5 6 Ni is 0.02 M O . The Ha and HeI 10 830-A lines at the nebular epoch show that the distribution of the bulk of 5 6 Ni can be represented approximately by a sphere of 5 6 Ni with a velocity of 1500 km s - 1 , which is shifted towards the far hemisphere by about 400 km s - 1 . The fine structure of the Ha at the photospheric epoch reminiscent of the 'Bochum event' in SN 1987A is analysed in terms of two plausible models: bipolar 5 6 Ni jets and non-monotonic behaviour of the Ha optical depth combined with the one-sided 5 6 Ni ejection. The late-time spectra show a dramatic transformation of the [O I] 6300-A line profile between days 465 and 510, which we interpret as an effect of dust condensation during this period. Late-time photometry supports the dust formation scenario after day 465. The [O I] line profile suggests that the dust occupies a sphere with velocity 800 km s - 1 and optical depth >> 10. The latter exceeds the optical depth of the dusty zone in SN 1987A by more than 10 times. Use is made of the Expanding Photosphere Method to estimate the distance and the explosion time, D 7.83 Mpc and t 0 ≃ 1999 October 24.5 UT, in accord with observational constraints on the explosion time and with other results of detailed studies of the method. The plateau brightness and duration combined with the expansion velocity suggest a pre-supernova radius of 120-150 R O . , ejecta mass of 10-11 M O . and explosion energy of (0.5-1) x 10 5 1 erg. The ejecta mass combined with the neutron star and a conservative assumption about mass loss implies the main sequence progenitor of M m s 12-14 M O . The derived mass range is in agreement with the upper limit to the mass found using pre-supernova field images by Smartt et al. From the [OI] 6300, 6364 A doublet luminosity we infer the oxygen mass to be a factor four lower than in SN 1987A which is consistent with the estimated SN 1999em progenitor mass according to nucleosynthesis and stellar evolution theory. We note a 'second-plateau' behaviour of the light curve after the main plateau at the beginning of the radioactive tail. This feature seems to be common to SNe IIP with low 5 6 Ni mass.
On the magnitude and sensitivity of the QBO response to a tropical volcanic eruption

15 Volcanic eruptions that inject sulphur dioxide into the stratosphere have the potential to alter large-scale circulation patterns, such as the quasi-biennial oscillation (QBO), which can affect weather and transport of chemical species. Here, we conduct simulations of tropical volcanic eruptions using the UM-UKCA aerosol-climate model with an explicit representation of the QBO. Eruptions emitting 60 Tg of SO 2 (i.e., 1815 Mt. Tambora-magnitude) and 15 Tg of SO 2 (i.e., 1991 Mt. Pinatubo-magnitude) were simulated at the equator initiated during two different QBO states. We show that tropical eruptions delay the 20 progression of the QBO phases, with the magnitude of the delay dependent on the initial wind shear in the lower stratosphere and a much longer delay when the shear is easterly than when it is westerly. The QBO response in our model is driven by vertical advection of momentum by the stronger tropical upwelling caused by heating due to the increased volcanic sulfate aerosol loading. Direct aerosol-induced warming with subsequent thermal wind adjustment, as proposed by previous studies, is found to only play a secondary role. This interpretation of the response is supported by comparison with a simple dynamical 25 model. The dependence of the magnitude of the response on the initial QBO state results from differences in the QBO secondary circulation. In the easterly shear zone of the QBO, the vertical component of the secondary circulation is upward and reinforces the anomalous upwelling driven by volcanic aerosol heating, whereas in the westerly shear zone the vertical component is downward and opposes the aerosol-induced upwelling. We also find a change to the latitudinal structure of the QBO, with the westerly phase of the QBO strengthening in the hemisphere with the lowest sulfate aerosol burden. Overall,
Variable effects of spatial resolution on modeling of nitrogen oxides

Abstract. The lifetime and concentration of nitrogen oxides (NOx) are susceptible to nonlinear production and loss and to the resolution of a chemical transport model (CTM). This is due to the strong spatial gradients of NOx and the dependence of its own chemical loss on such gradients. In this study, we use the GEOS-Chem CTM in its high-performance implementation (GCHP) to investigate NOx simulations over the eastern United States across a wide range of spatial model resolutions (six different horizontal grids from 13 to 181 km). Following increasing grid size, afternoon surface NOx mixing ratios over July 2015 generally decrease over the Great Lakes region (GL) and increase over the southern states of the US region (SS), yielding regional differences (181 km vs. 13 km) of −16 % (in the GL) to 7 % (in the SS); meanwhile, hydrogen oxide radicals (HOx) increase over both regions, consistent with their different chemical regimes (i.e., NOx-saturated in the GL and NOx-limited in the SS). Nighttime titration of ozone by surface nitric oxide (NO) was found to be more efficient at coarser resolutions, leading to longer NOx lifetimes and higher surface mixing ratios of nitrogen dioxide (NO2) over the GL in January 2015. The tropospheric NO2 column density at typical afternoon satellite overpass time has spatially more coherent negative biases (e.g., −8 % over the GL) at coarser resolutions in July, which reversed the positive biases of surface NOx over the SS. The reduced NOx aloft (>1 km altitude) at coarser resolutions was attributable to the enhanced HOx that intrudes into the upper troposphere. Application of coarse-resolution simulations for interpreting satellite NO2 columns will generally underestimate surface NO2 over the GL and overestimate surface NO2 over the SS in summer, but it will uniformly overestimate NOx emissions over both regions. This study significantly broadens understanding of factors contributing to NOx resolution effects and the role of fine-resolution data in accurately simulating and interpreting NOx and its relevance to air quality.
The Interpolating Airy Kernels for the β = 1 and β = 4 Elliptic Ginibre Ensembles

We consider two families of non-Hermitian Gaussian random matrices, namely the elliptic Ginibre ensembles of asymmetric N -by- N matrices with Dyson index β = 1 (real elements) and with β = 4 (quaternion-real elements). Both ensembles have already been solved for ﬁnite N using the method of skew-orthogonal polynomials, given for these particular ensembles in terms of Hermite polynomials in the complex plane. In this paper we investigate the microscopic weakly non-Hermitian large- N limit of each ensemble in the vicinity of the largest or smallest real eigenvalue. Speciﬁcally, we derive the limiting matrix-kernels for each case, from which all the eigenvalue correlation functions can be determined. Wecallthesenewkernelsthe“interpolating”Airykernels,sincewecanrecover—asopposing limitingcases—notonlythewell-knownAirykernelsfortheHermitianensembles,butalso thecomplementaryerrorfunctionandPoissonkernelsforthemaximallynon-Hermitian ensemblesattheedgeofthespectrum.TogetherwiththeknowninterpolatingAirykernel for β = 2, which we rederive here as well, this completes the analysis of all three elliptic Ginibre ensembles in the microscopic scaling limit at the spectral edge.
Rumor Processes on N and Discrete Renewal Processes

We study two rumor processes on N , the dynamics of which are related to an SI epidemic model with long range transmission. Both models start with one spreader at site 0 and ignorants at all the other sites of N , but differ by the transmission mechanism. In one model, the spreaders transmit the information within a random distance on their right, and in the other the ignorants take the information from a spreader within a random distance on their left. We obtain the probability of survival, information on the distribution of the range of the rumor and limit theorems for the proportion of spreaders. The key step of our proofs is to show that, in each model, the position of the spreaders on N can be related to a suitably chosen discrete renewal process.
Characterisation of Forest Resources and the Local Communities for the Choice of Sustainable Forest Management Strategies in Uganda

The decline in natural forest resources in the tropics due to ineffective management practices has reached unprecedented levels with the most affected forests being in developing countries. Efforts to manage these resources sustainably have proven futile. Understanding the nature and status of the forest resources and the communities is crucial for devising effective management strategies. The study was designed to characterise forest resources and the local communities to aid in the choice of effective management strategies for forest resources. The study was conducted in Yumbe district, northwestern Uganda, using a cross-sectional research design. It targeted communities living in the sub-counties of Kei, Kerwa, and Midigo. Data were collected using questionnaires, key informant interviews, focus group discussions, participant observations, and remote sensing. Pearson correlation and regression were used to analyse quantitative data, while thematic analysis was used to analyse qualitative data. The correlation p-values (Sig.) of less than . 05 were statistically significant, implying a strong relationship between socioeconomic and demographic characteristics of households and the choice of forest management strategies. The results further showed that the local communities were poor, illiterate, and dependent on subsistence farming and forest resources. The forest resources both in public and communal lands were in a state of serious decline. They were non-timber-based, accessible to the local community and dominated by woodland and other grassland mosaics. The local community used sustainable management practices, such as selective harvesting, tree planting, and gazetting some sites as sacred places. The management strategies used were forest type-specific, e.g., traditional for community forests and modern for public forests. The most important factor influencing the choice of management strategy was the level of education with an R Square value of . 112. The study, therefore, recommends an improvement in the education of the local communities and the integration of local skills and practices to promote community-based approaches in sustainable forest resource management.
Yield stresses in electrorheological fluids

We describe and determine the static and dynamic (Bingham) yield stresses in an electrorheological (ER) fluid from a microstructural model. The model relates both these yield stresses to the electrostatic energy determined from the suspension capacitance matrix, which we developed previously for the dynamic simulation of an ER fluid. The static yield stress is determined from nonlinear elasticity strain‐energy theory applied to an ER fluid for a variety of volume fractions and particle‐to‐fluid dielectric constant ratios. The static yield stress increases with the dielectric constant ratio and exhibits a maximum at 40 Vol % particles for dielectric constant ratios of 4 or less. From the capacitance of the suspension we also compute the zero‐frequency birefringence of the ER fluid and show that it follows a nonlinear stress‐optical rule. The dynamic yield stress, as we have observed in our previous simulations, dominates the rheology of the ER fluid at large electric field strengths. At the same time the e.
A Mechanistic Study on the Formation of Acetone (CH3COCH3), Propanal (CH3CH2CHO), Propylene Oxide (c-CH3CHOCH2) along with Their Propenol Enols (CH3CHCHOH/CH3C(OH)CH2) in Interstellar Analog Ices

Carbonyl-bearing complex organic molecules (COMs) in the interstellar medium (ISM) are of significant importance due to their role as potential precursors to biomolecules. Simple aldehydes and ketones like acetaldehyde, acetone, and propanal have been recognized as fundamental molecular building blocks and tracers of chemical processes involved in the formation of distinct COMs in molecular clouds and star-forming regions. Although previous laboratory simulation experiments and modeling established the potential formation pathways of interstellar acetaldehyde and propanal, the underlying formation routes to the simplest ketone—acetone—in the ISM are still elusive. Herein, we performed a systematic study to unravel the synthesis of acetone, its propanal and propylene oxide isomers, as well as the propenol tautomers in interstellar analog ices composed of methane and acetaldehyde along with isotopic-substitution studies to trace the reaction pathways of the reactive intermediates. Chemical processes in the ices were triggered at 5.0 K upon exposure to proxies of Galactic cosmic rays in the form of energetic electrons. The products were detected isomer-selectively via vacuum ultraviolet (VUV) photoionization reflectron time-of-flight mass spectrometry. In our experiments, the branching ratio of acetone (CH3COCH3):propylene oxide (c-CH3CHOCH2):propanal (CH3CH2CHO) was determined to be (4.82 ± 0.05):(2.86 ± 0.13):1. The radical–radical recombination reaction leading to acetone emerged as the dominant channel. The propenols appeared only at a higher radiation dose via keto–enol tautomerization. The current study provides mechanistic information on the fundamental nonequilibrium pathways that may be responsible for the formation of acetone and its (enol) isomers inside the interstellar icy grains.
Analysis and Approximation of Conservation Laws with Source Terms

We consider a conservation law of the form (CL)I>ut + f(u)x = ax, where $a(\cdot)$ is a bounded piecewise smooth source term and f an even convex function. We first characterize the solution to the Riemann problem through a new Lax-type formula. Then we prove that for $a(\cdot)$ fixed, the semigroup associated with (CL)is an L1 contraction, and we obtain an existence theorem for weak solutions to (CL). We conclude by constructing Godunov-type difference schemes and proving that these schemes are $L^\infty$ stable and have stable steady solutions similar in structure to those of (CL). Some numerical tests are reported.
On the global instability of free disturbances with a time-dependent nonlinear viscous critical layer

A theoretical study is made of the global nonlinear growth or decay, in space and time, of an unsteady non-neutral disturbance/wavepacket when a time-dependent nonlinear viscous critical layer is present. The basic flow considered is a steady quasiparallel channel flow, boundary layer or liquid-layer flow at high Reynolds number. The unsteadiness with regard to the critical layer shows itself less in the internal dynamics than in the relatively slow movement of the layer across the flow, the temporal and spatial rate of movement discussed being sufficient to affect the nonlinear viscous balance in the layer. This greatly reduces the mean-flow distortions produced. The disturbance amplitude, in contrast, responds nonlinearly on faster time- and space-scales, both inside and outside the critical layer. These slower- and faster-scale properties inside the critical layer and outside, i.e. globally, are coupled together in general. The work addresses first the structure and nonlinear evolution equations for the growing or decaying free disturbance and the critical layer. But preliminary analysis in special cases suggests, among other things, the significant result that previous nonlinear studies based on quasineutral assumptions give unstable subcritical threshold amplitudes, above which increasingly fast disturbance growth takes place globally.
The Impact of Freeze-Thaw Cycles on the Integrity of SARS-COV-2 Viral Culture Fluids and Clinical Remnant Samples in Antigen or Nucleic Acid Testing

Preservation at ultra-low temperatures has been a gold standard for long-term storage of many types of clinical specimens including the SARS-CoV-2 virus. The frozen specimens can be easily transported and tested later. In addition, de-identified frozen remnant samples are resources for many preclinical or clinical studies. It is therefore crucial to understand whether freeze and thaw cycles (FTCs) can adversely affect SARS-CoV-2 test performance when frozen samples are tested. Some early studies suggest that the FTCs increased the cycles threshold (Ct) of RT-PCR indicating the potential degradation of the SARS-CoV-2 nucleic acid after FTCs, while the others did not report any significant changes in the SARS-CoV-2 nucleic acids after the FTCs. Moreover, the impact of FTCs on the performance of the SARS-CoV-2 antigen test is scarcely reported. In this study, we performed paired nucleic acid and rapid antigen tests on the same samples to investigate and directly compare how FTCs affect the performance of two types of tests. Both inactivated viral culture fluid samples and clinical remnant samples were studied. Our results showed that FTCs had minimal negative effects on the performance of the rapid SARS-CoV-2 antigen test, and the test results remained largely consistent throughout the FTCs, whereas the Ct values of RT-PCR increased with the increase of the FTC numbers. In addition, our data also demonstrated that the SARS-CoV-2 is preserved better in VTM than PBS during FTCs in regard to nucleic acid testing.