Miracle-dz/UniFAR-FTUs huggingface dataset:
Prospective evaluation of immunological, molecular-genetic, image-based and microbial analyses to characterize tumor response and control in patients with unresectable stage III NSCLC treated with concurrent chemoradiotherapy followed by consolidation therapy with durvalumab (PRECISION): protocol fo

Background Concurrent platinum-based chemoradiotherapy (CRT) followed by durvalumab maintenance treatment represents the new standard of care in unresectable stage III non-small cell lung cancer (NSCLC). In this prospective hypothesis-generating single-center study, we aim to identify a framework of prognostic and predictive biomarkers by longitudinal characterization of tumor- and patient (host)-related parameters over all phases of multimodal treatment. Methods This study will enroll 40 patients (≥18 years, Eastern Cooperative Oncology Group performance status (ECOG PS) 0–2, with a diagnosis of PD-L1 positive (≥1%), inoperable stage III NSCLC) with an indication for CRT followed by maintenance treatment with durvalumab according to European Medicines Agency (EMA) approval. Comprehensive analysis will include peripheral blood cellular and humoral immunophenotyping and circulating tumor DNA as well as gut/saliva microbiota analyses. Additional morphological analysis with 18F-FDG-PET/computed tomography (CT) before, 6 weeks, 6 and 12 months after the end of CRT is included. Statistical analysis using multiple testing will be used to examine the impact of different parameters on progression-free survival (PFS) and overall survival (OS) as well as tumor response and response duration. Discussion This protocol describes the methodology of a comprehensive biomarker study in order to identify a framework of prognostic and predictive markers for unresectable stage III NSCLC in a real-world setting. Trial Registration ClinicalTrials.gov identifier (NCT05027165), data registered on August 2021.
Photoelectric Properties of Planar and Mesoporous Structured Perovskite Solar Cells

The high efficiency of perovskite solar cells strongly depends on the quality of perovskite films and carrier extraction layers. Here, we present the results of an investigation of the photoelectric properties of solar cells based on perovskite films grown on compact and mesoporous titanium dioxide layers. Kinetics of charge carrier transport and their extraction in triple-cation perovskite solar cells were studied by using transient photovoltage and time-resolved photoluminescence decay measurements. X-ray diffraction analysis revealed that the crystallinity of the perovskite films grown on mesoporous titanium dioxide is better compared to the films grown on compact TiO2. Mesoporous structured perovskite solar cells are found to have higher power conversion efficiency mainly due to enlarged perovskite/mesoporous -TiO2 interfacial area and better crystallinity of their perovskite films.
Association of Smartphone Use Duration with Physical Fitness among University Students: Focus on Strength and Flexibility

High-frequency smartphone use leads to physical inactivity and may consequently cause the loss of physical fitness. Although the relationship between smartphone usage and physical fitness has been investigated, most of these studies focused on partial physical fitness, and the evaluation of the duration of smartphone use was insufficient. Therefore, this study aimed to investigate the relationship between the time period of using smart phones and physical fitness in Chinese university students. In this cross-sectional study, 8977 college students (5189 men and 3788 women) were enrolled. The assessment of smartphone usage was performed using a self-reported questionnaire. Physical fitness was measured in a sports facility, consisting of grip strength, standing long jump, and sit-and-reach test. The post adjustment relationship between smartphone use duration and physical fitness was examined by using the ANCOVA test. In the final adjusted model, an inverse association was observed between the smartphone use duration and grip strength in male and female participants (p = 0.003 and <0.001, respectively). The smartphone use duration was also negatively associated with standing long jump in both sexes (p = 0.003 for male and = 0.026 for female). In male participants, the longer the period of using smartphones, the lower their flexibility (p = 0.026). In conclusion, this study investigated the association between the duration of smartphone use and physical fitness. The results showed that longer durations of smartphone use were associated with weaker grip strength, a shorter standing long jump, and lower flexibility. Controlling smartphone-use duration might be beneficial for physical fitness among university students.
Extended Openmax Approach for the Classification of Radar Images With a Rejection Option

The closed-set assumption in conventional classifiers, such as the Softmax, constrains deep networks to select an output from the given known classes. However, the classification in a real-world scenario should account for open sets where a new class of targets, which has not been included in the training phase, can easily confuse the classifier. Therefore, it is necessary to not only correctly classify known classes but also fundamentally deal with unknown ones. In this article, we extend the Openmax approach, which has been introduced for open-set recognition in the optical domain, by offering solutions to its inherent limitations. The motivation behind the work is to propose a more accurate and robust classifier for the open-set recognition problem in synthetic aperture radar (SAR) images, without having any prior knowledge about the incoming unknown data. A number of real-data experiments are conducted to demonstrate the effectiveness of the proposed method on the basis of selected performance metrics. In particular, the Moving and Stationary Target Acquisition and Recognition dataset, which contains SAR images of ten military vehicles, is used for training and inference of a convolutional neural network, with an option to recognize open-set images.
Upper and Lower Airways Evaluation and Its Relationship with Dynamic Upper Airway Obstruction in Racehorses

Simple Summary Dynamic upper airway obstructions (DUAO) are a common cause of poor performance in racehorses, including different forms which vary in severity. Previous studies reported contrasting results concerning the contribution of abnormal pharyngo-laryngeal appearance and airway inflammation to the pathogenesis of DUAO. The present study aimed to evaluate possible associations between the development of DUAO and resting airway endoscopic findings, epiglottis size, airways inflammation and exercise-induced pulmonary hemorrhage (EIPH). These relationships were statistically investigated retrospectively in 360 racehorses (Standardbreds and Thoroughbreds) with poor performance or abnormal respiratory noises. A flaccid appearance of the epiglottis was associated with the occurrence of the dorsal displacement of the soft palate, while no relationship was detected between DUAO and epiglottis length. Inflammation of the upper and lower airways was not related with the development of DUAO, nor were horses with DUAO more prone to experience EIPH. These results suggest that epiglottis may contribute to upper airway stability, while inflammation does not predispose horses to the onset of DUAO. Abstract Dynamic upper airway obstructions (DUAO) are common in racehorses, but their pathogenetic mechanisms have not been completely clarified yet. Multiple studies suggest that alterations of the pharyngo-laryngeal region visible at resting endoscopy may be predictive of the onset of DUAO, and the development of DUAO may be associated with pharyngeal lymphoid hyperplasia (PLH), lower airway inflammation (LAI) and exercise-induced pulmonary hemorrhage (EIPH). The present study aims to investigate the possible relationship between the findings of a complete resting evaluation of the upper and lower airways and DUAO. In this retrospective study, 360 racehorses (Standardbreds and Thoroughbreds) referred for poor performance or abnormal respiratory noises were enrolled and underwent a diagnostic protocol including resting and high-speed treadmill endoscopy, cytological examination of the bronchoalveolar lavage fluid and radiographic assessment of the epiglottis length. In this population, epiglottis flaccidity was associated with dorsal displacement of the soft palate, while no relationship was detected between DUAO and epiglottis length. No associations were detected between DUAO and PLH, LAI or EIPH. In conclusion, it is likely that epiglottis plays a role in upper airway stability, while airways inflammation does not seem to be involved in the pathogenesis of DUAO.
Chemical Composition of the “Galo de Barcelos” (Barcelos Rooster Raw Meat)

Simple Summary The assessment of traditional products is important for the sustainability of agricultural systems and the preservation of a unique gastronomic heritage. The present study aims to determine the chemical composition of “Galo de “Barcelos”” (“Barcelos” Rooster) raw meat, used in the preparation of the typical Portuguese dish “Roasted Rooster from “Barcelos””, in order to evaluate and protect this gastronomic and cultural tradition. The influence of the genotype on the final product was verified, concerning total protein, and fat contents, and a favorable ratio of n-6/n-3 fatty acids of the Sasso line was compared to the “Amarela” breed, contributing to the promotion of its gastronomic potential. Abstract Ten roosters produced according to “Barcelos Confraria” rules and ten roosters of autochthonous “Amarela” breed, reared on a similar traditional production system, were analyzed, and the chemical profile of two of the most significant meat portions, breast and drumstick, was determined. The results demonstrated that the “Barcelos” rooster raw meat is rich in proteins (22.3%) and fat (4.31%), particularly in monounsaturated fatty acids (39.1%). Significant differences (p ≤ 0.01) were observed, with the breast having a higher protein content (25.1 vs. 19.7%) and less fat (1.9% vs. 6.7%), compared to the drumstick. The fatty acid profile revealed (SFA 30.0%, MUFA 39.1%, and PUFA 24.6%) a similar composition to the roosters reared in the traditional or organic production systems, such as the “Amarela” autochthonous rooster. The “Barcelos” rooster can be regarded as a highly nutritional meat, with an interesting chemical profile ensuring a high-quality traditional product to consumers.
The Effect of Outdoor Environmental Exposure on Readmission Rates for Children and Adolescents with Asthma—A Systematic Review

The burden of asthma readmission for children and adolescents is approximately 10% worldwide. Research has been synthesised for behavioural and indoor impacts; however, no such synthesis has been conducted for outdoor environmental exposures. This systematic review aims to evaluate and synthesise the impact the outdoor environment has on readmission rates for children or adolescents with asthma. We conducted a systematic search of seven databases and hand searched reference lists of articles published up until 18 January 2021. There were 12 out of 392 studies eligible for inclusion. Overall, most studies showed that outdoor environments impact on readmission; however, the strength of association is seen to be stronger in a particular subpopulation of each study depending on the exposure investigated. The evidence for the association between outdoor environmental exposure and readmission rates for children or adolescents with asthma is increasing; however, it is complicated by potential confounders such as socioeconomic factors, ethnicity, indoor air pollutants, and other behavioural factors. Further research is required to differentiate between them. Additionally, further studies need to be undertaken in further countries other than the United States of America to understand the full relationship.
Comment on: ``Semiclassical theory of spin-orbit interactions using spin coherent states''

We point out that a certain kind of combined classical translational and spin dynamics -- claimed in [M. Pletyukhov, et al. Phys. Rev. Lett. 89 (2002) 116601] to arise from the Pauli equation in the semiclassical limit $\hbar\to0$ for fixed spin -- only shows up if one simultaneously considers the high spin limit $S\to\infty$.
Statistical decisions based directly on the likelihood function

This thesis studies the possibility of basing statistical decisions directly on the likelihood function. By describing the problems of statistical inference as particular decision problems, the usual likelihood-based inference methods can be obtained as special cases. These are among the most appreciated methods of statistical inference, although in general they are not optimal from the repeated sampling point of view. In fact, their principal advantages are that, being based on the likelihood function, they are intuitive, generally applicable, and asymptotically optimal. These properties are shared by all the methods that base decisions on the likelihood function in some reasonable way. The decision criteria based on the likelihood function are analyzed, and some of their decision theoretic properties are related to their representations by means of nonadditive integrals; in this connection, the theory of integration with respect to nonadditive measures is reviewed and extended. Some statistical properties of the likelihood-based decision criteria are studied as well, and a paradigmatic example of statistical decision problem is examined in more detail: the problem of point estimation in Euclidean spaces. A simple, intuitive decision criterion emerges as particularly interesting: the MPL criterion, which consists in using the likelihood of the statistical models to weight the respective losses, before applying the minimax criterion. The likelihood function can be interpreted as a measure of the relative plausibility of the statistical models considered, and thus as the second level of a hierarchical description of uncertain knowledge, of which the statistical models form the rst level. There is a similarity with the Bayesian model, in which the second level consists of a probability measure, but the measure of relative plausibility considered in this thesis can also describe
Determinants of Behavioral Intention and Use of Interactive Whiteboard by K-12 Teachers in Remote and Rural Areas

Interactive Whiteboard (IWB) has recently been used to replace the TWB (traditional whiteboard), with many of its features being observed to help teachers in educational activities. This is based on effectively and efficiently increasing the teacher-student interaction. Therefore, this study aims to analyze the determinants of Behavioral Intention (BI) and the use of interactive whiteboards by K-12 teachers, in remote and rural Chinese areas. The Modified-Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) model was used in this analysis, as a learning medium to deliver the subject matter to students. The sample and population were also the teachers in the Guangxi Zhuang Autonomous Region, China, where 171 voluntary respondents participated in this study. Furthermore, the obtained data were processed using a Structural Equation Model (SEM) approach, through the Smart-PLS software. The results showed that Habit and Hedonic Motivation had a significant influence on the Behavioral Intention (BI) of teachers, toward the utilization of IWB in remote and rural areas. Besides this, Facilitating Conditions (FCs) and BI also had a significant positive effect on Usage Behavior. Based on these results, important information was provided to school principals, local governments, and teachers for education quality improvement, regarding the patterns of increasing IWB utilization in remote and rural areas.
Regeneration-Associated Transitional State Cells in Pulmonary Fibrosis

Pulmonary fibrosis is a chronic, progressive fibrosing interstitial disease. It is characterized by fibroblast proliferation, myofibroblast activation, and massive extracellular matrix deposition. These processes result in loss of lung parenchyma function. The transdifferentiation of alveolar epithelial type II (AEC2) to alveolar epithelial type I cells (AEC1) plays an important role in the epithelial repair after lung injury. Pulmonary fibrosis begins when this transdifferentiation process is blocked. Several recent studies have found that novel transitional state cells (intermediate states in the transdifferentiation of AEC2 to AEC1) can potentially regenerate the alveolar epithelium surface and promote a repair process. During the AEC2 to AEC1 trans-differentiation process after injury, AEC2 lose their specific markers and become transitional state cells. Furthermore, transdifferentiation of transitional state cells into AEC1 is the critical step for lung repair. However, transitional cells stagnate in the intermediate states in which failure of transdifferentiation to AEC1 may induce an inadequate repair process and pulmonary fibrosis. In this review, we focus on the traits, origins, functions, and activation of signaling pathways of the transitional state cell and its communication with other cells. We also provide a new opinion on pulmonary fibrosis pathogenesis mechanisms and novel therapeutic targets.
Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification

Extracellular acidification has been shown to be an important characteristic of invasive tumors, as it promotes invasion and migration but also resistance to treatments. Targeting transporters involved in the regulation of tumor pH constitutes a promising anti-tumor approach, as it would disrupt cellular pH homeostasis and negatively impact tumor growth. In this study, we evaluated the impact of syrosingopine, an inhibitor of MCT1 and MCT4, as a modulator of tumor metabolism and extracellular acidification in human breast cancer (MDA-MB-231) and pharyngeal squamous cell carcinoma (FaDu) cell models. In both models in vitro, we observed that exposure to syrosingopine led to a decrease in the extracellular acidification rate, intracellular pH, glucose consumption, lactate secretion and tumor cell proliferation with an increase in the number of late apoptotic/necrotic cells. However, in vivo experiments using the MDA-MB-231 model treated with a daily injection of syrosingopine did not reveal any significant change in extracellular pH (pHe) (as measured using CEST-MRI) or primary tumor growth. Overall, our study suggests that targeting MCT could lead to profound changes in tumor cell metabolism and proliferation, and it warrants further research to identify candidates without off-target effects.
Constructing a Carbon-Encapsulated Carbon Composite Material with Hierarchically Porous Architectures for Efficient Capacitive Storage in Organic Supercapacitors

Hierarchical porous activated carbon (HPAC) materials with fascinating porous features are favored for their function as active materials for supercapacitors. However, achieving high mass-loading of the HPAC electrodes remains challenging. Inspired by the concepts of carbon/carbon (C/C) composites and hydrogels, a novel hydrogel-derived HPAC (H-HPAC) encapsulated H-HPAC (H@H) composite material was successfully synthesized in this study. In comparison with the original H-HPAC, it is noticed that the specific surface area and pore parameters of the resulting H@H are observably decreased, while the proportions of nitrogen species are dramatically enhanced. The free-standing and flexible H@H electrodes with a mass-loading of 7.5 mg/cm2 are further prepared for electrochemical measurements. The experiments revealed remarkable reversible capacitance (118.6 F/g at 1 mA/cm2), rate capability (73.9 F/g at 10 mA/cm2), and cycling stability (76.6% of retention after 30,000 cycles at 5 mA) are delivered by the coin-type symmetric cells. The cycling stability is even better than that of the H-HPAC electrode. Consequently, the findings of the present study suggest that the nature of the HPAC surface is a significant factor affecting the corresponding capacitive performances.
Psychologists’ engagement in reflective practice and experiences of burnout: a correlational analysis

ABSTRACT Psychologists are prone to experiences of burnout due to the nature of their work. They are encouraged to engage in reflective practice for gaining self-awareness, such as when their psychological wellbeing is having an impact on their ability to effectively work with clients. This study was the first to investigate the relationships between psychologists’ burnout levels and reflective practices. Psychologists from Australia (n = 110) and other countries (n = 10) completed the Copenhagen Burnout Inventory (CBI), Reflective Practice Questionnaire (RPQ), and Depression Anxiety Stress Scale – Short Form (DASS-21) in an online survey. The correlations between the CBI and RPQ scales were examined. Pre-liminary screening revealed the general mental health of the sample was normal. Two of the 10 RPQ domains were correlated with personal-, work-, and/or client-related burnout: Stress Interacting with Clients and Job Satisfaction. This study illuminated the importance of adequate supervision for psychologists to support their ability to manage their workloads, and wellbeing in the workplace. Person-centered and systemic approaches for addressing RP and burnout in the field of psychology are critical.
Diagnostic Performance of Height-Estimated Baseline Creatinine in Diagnosing Acute Kidney Injury in Children with Type 1 Diabetes Mellitus Onset

At type 1 diabetes mellitus (T1DM) onset, acute kidney injury (AKI) is very common. To diagnose AKI, the availability of a baseline serum creatinine (bSCr) is pivotal. However, in most hospitalized children the bSCr is unknown. We aimed to test whether the bSCr estimated on the basis of height (ebSCr) could be a reliable surrogate for AKI diagnosis compared with the measured bSCr (mbSCr). As the mbSCr, we considered the creatinine measured 14 days after T1DM onset while ebSCr (mg/dL) = (k × height [cm])/120 mL/min/1.73 m2, where k = 0.55 for children and adolescent girls and k = 0.7 for adolescent boys. AKI was defined as serum creatinine values >1.5 times the baseline creatinine. Kappa statistics and the percentage of agreement in AKI classification by ebSCr–AKI versus mbSCr–AKI definition methods were calculated. Bland–Altman plots were used to show the agreement between the creatinine ratio (highest/baseline creatinine; HC/BC) calculated with mbSCr and ebSCr. The number of 163 patients with T1DM onset were included. On the basis of mbSCr, 66/163 (40.5%) presented AKI while, on the basis of ebSCr, 50/163 (30.7%) accomplished AKI definition. ebSCr showed good correlation with mbSCr using both the Spearman test (rho = 0.67; p < 0.001) and regression analysis (r = 0.68; p < 0.001). Moreover, at the Bland–Altman plots, the bias of the highest/baseline creatinine ratio calculated on the basis of the mbSCr compared to ebSCr was minimal (bias = −0.08 mg/dL; 95% limits of agreement = −0.23/0.39). AKI determined using ebSCr showed 90% agreement with AKI determined using mbSCr (kappa = 0.66; p < 0.001). Finally, we compared the area under a receiver–operating characteristic curve (AUROC) of HC/BC ratio calculated on the basis of ebSCr with AUROC of the gold standard HC/BC ratio calculated on the basis of mbSCr. As expected, the gold standard had an AUROC = 1.00 with a 95% confidence interval (CI) between 0.98 and 1.00, p < 0.001. The HC/BC ratio calculated on the basis of ebSCr also had significant AUROC (AUROC = 0.94; 95% CI: 0.90–0.97; p < 0.001). The comparison of the two ROC curves showed a p < 0.001. In conclusion, when mbSCr is unknown in patients with T1DM onset, the ebSCr calculated on the basis of height could be an alternative to orientate clinicians toward AKI diagnosis.