Miracle-dz/UniFAR-FTUs huggingface dataset:
Eosinophilic Esophagitis: Cytokines Expression and Fibrotic Markers in Comparison to Celiac Disease

Introduction: Eosinophilic esophagitis (EoE) is now recognized as the main inflammatory condition that leads to fibrosis, unlike other chronic inflammatory gastrointestinal diseases, such as celiac disease. The aim of our study is to characterize the collagen deposition and cytokine expression involved in the fibrogenic response in patients affected by EoE in comparison to celiac disease. Materials and Methods: Consecutive patients with a clinical suspicion of untreated EoE or active celiac disease were enrolled. In the control group, patients with negative upper endoscopy were included. Total RNA was isolated from biopsy specimens using a commercial kit (SV Total RNA Isolation System, Promega Italia Srl). Quantitative real-time PCR (qRT-PCR) was performed in triplicate using a StepOne™ Real-Time PCR instrument (Thermo Fisher Scientific, Monza, Italy). mRNA encoding for inflammatory molecules: interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 13 (IL-13), and fibrotic markers: transforming growth factor beta 1 (TGF-β), mitogen-activated protein kinase kinase kinase 7 (MAP3K7), serpin family E member 1 (SERPINE1), were quantified using TaqMan Gene Expression Assays (Applied Biosystems). RESULTS. In EoE, the qPCR analysis showed an increase in all the inflammatory cytokines. Both IL-5 and Il-3 mRNA expression resulted in a statistically significant increase in oesophageal mucosa with respect to the celiac duodenum, while no differences were present in IL-4 expression. TGF-β expression was similar to the controls in the mid esophagus but reduced in the distal EoE esophagus (RQ: 0.46 ± 0.1). MAP3K7 expression was reduced in the mid esophagus (RQ: 0.59 ± 0.3) and increased in the distal esophagus (RQ: 1.75 ± 0.6). In turn, the expression of SERPINE1 was increased in both segments and was higher in the mid than in the distal esophagus (RQ: 5.25 ± 3.9, 1.92 ± 0.9, respectively). Collagen deposition was greater in the distal esophagus compared to the mid esophagus [18.1% ± 8 vs. 1.3% ± 1; p = 0.008]. Conclusions: The present study confirms the esophageal fibrotic involution involving the distal esophagus and shows that the inflammatory pathway in EoE is peculiar to this disease and different from other chronic inflammatory gastrointestinal disorders such as celiac disease.
The role of life purpose and passion for coaching in subjective well-being of sport coaches

ABSTRACT The purpose of this study was to examine the role of purpose in life in coaches’ subjective happiness and life satisfaction and the role of harmonious and obsessive work passions in these relationships. Collegiate coaches (N = 379) completed questionnaires assessing sense of purpose in life (awakening to purpose, awareness of purpose, and altruistic purpose), passion for coaching (harmonious, obsessive), and subjective well-being (subjective happiness, life satisfaction). Structural equation modelling showed that awareness of purpose was a positive direct predictor of subjective happiness and life satisfaction. Positive indirect relationships through harmonious passion for coaching were found between awareness of purpose and both measures of subjective well-being and between awakening to purpose and life satisfaction. Opposing indirect relationships through harmonious and obsessive work passions were found between awakening to purpose and subjective happiness. Altruistic purpose, on the other hand, was not a significant predictor of passions for work and subjective well-being. Structural invariance was tested across gender (male, female), Division (I, III), and position (head coach, assistant coaches), showing only a few differences across gender and position. Overall, findings highlight the importance of life purpose in strengthening coaches’ harmonious passion for coaching and their subjective well-being.
Synthesis and Characterization of Phosphinecarboxamide and Phosphinecarbothioamide, and Their Complexation with Palladium(II) Complex

Reactions of isocyanates/isothiocyanates with primary and secondary phosphines without solvent at room temperature afforded phosphinecarboxamide/phosphinecarbothioamide, respectively, in excellent yields. Furthermore, palladium complex Pd(COD)Cl2 was allowed to react with Ph2PC(O)NHPh (1a) to afford [Pd{Ph2PC(O)NHPh-κP}2Cl2] (3). On the other hand, the reaction of Pd(COD)Cl2 with 1 eq. of Ph2PC(S)NHPh (2a) afforded [PdCl2{Ph2PC(S)NHPh-κP,S}] (4). In the case of a 1:2 molar ratio, [PdCl{Ph2PC(S)NHPh-κP,S}{Ph2PC(S)NHPh-κP}]Cl (5) was formed. The newly obtained compounds were fully characterized using multielement NMR measurements and elemental analyses. In addition, the molecular structures of Ph2PC(O)NH(CH2)2Cl (1j), Ph2PC(S)NHPh(4-Cl) (2c), and 3–5 were determined using single-crystal X-ray diffraction.
A Study of Part-Time Worker Students at the Postgraduate Level

This paper attempts to analyze a study of part-time worker students at the postgraduate level in economics education in Kathmandu valley. The students who continue their postgraduate studies and jobs are known as part-time working students. This paper is based on a qualitative research design. Data were collected from in-depth personal interviews. For this purpose, four students were purposively selected covering gender from the first and second semesters. This paper has two-fold findings: most students engage in part-time work to gain thirst and survival and develop future working experience in the second. However, both types of students reported that part-time jobs support a lower survival level, which has disrupted their study. Furthermore, both types of students involved in part-time work do not seem satisfied with their job and study.
Adjustment of Pointing & Tracking System of ERT-5 and Results of Some Bright Source Observations

In this report we inform on adjustment of pointing and tracking system and calibration procedures of ERT5. Also we inform on the test of 1420 MHz HI receiver SpectraCyber ( SC ) from Radio Astronomy Supplies [1] which is installed on ERT5 and the results of some bright source observations with it. Errors of pointing of ERT5 before correction were more than 7. After the first stage of correction these errors had been reduced to nearly 2 o level. Testing of the Neutral hydrogen ( HI ) receiver SC shows that the system is functioning properly. We also discuss the first observations made in Turkey at the 1420 MHz line and continuum and other results of some observations of Galactic and extragalactic bright sources.
Some properties of distal actions on locally compact groups

We consider the actions of (semi)groups on a locally compact group by automorphisms. We show the equivalence of distality and pointwise distality for the actions of a certain class of groups. We obtain a decomposition for contraction groups of an automorphism under certain conditions. We give a necessary and sufficient condition for distality of an automorphism in terms of its contraction group. We compare classes of (pointwise) distal groups and groups whose closed subgroups are unimodular. In particular, we study relations between distality, unimodularity and contraction subgroups.
Observations of Six Southern Galaxies in the 12CO(J = 1—0) Transition

Abstract We have mapped the southern galaxies NGC 613, 1313, 1433, 1566, 1672 and 2442 in the 12CO(J = 1 → 0) transition with the 15-m Swedish European Submillimetre Telescope (SEST). The sample is based on galaxies previously observed in radio continuum with the Molonglo Observatory Synthesis Telescope (MOST). Strong emission is seen from the barred galaxies NGC 613 and NGC 2442 and from the active galaxies NGC 1566 and 1672. The weakest emission was from NGC 1433, while the Sd spiral NGC 1313 was not detected.
The birth of radio millisecond pulsars and their high-energy signature

Millisecond pulsars (MSPs) are thought to born in low-mass X-ray binaries when the neutron star has gained enough angular momentum from the accreting materials of its companion star. It is generally believed that a radio MSP is born when the neutron star stops accreting and enters a rotation-powered state. Exactly what happens during the transition time was poorly understood until a year ago. In the past year, observations have revealed a few objects that not only switched from one state to the other (as predicted in the above picture), but also have swung between the two states within weeks to years. In this work, we present observations of two of these transition objects (PSR J1023+0038 and XSS J12270-4859) and a theoretical framework that tries to explain their high-energy radiation.
EFFECT DIFFERENT LEVELS OF TURMERIC ROOT POWDER TO DIET ON SOME TRAITS OF BROILER EXPOSED TO HEAT STRESS

This study was carried out in the poultry field in Jadiriyah, affiliated with the Department of Animal Production / College of Agricultural Engineering Sciences - University of Baghdad. This experiment used 480 one-day-old, unsexed broiler chicks of the broiler breed (Ross-308) with an average weight of 39.8 g to investigate the effect of adding different levels of turmeric root (CURCUMA LONGA) (CURCUMA LONGA) powder to the diet on some characteristics and physiology of commercial broilers exposed to heat stress. Chicks were distributed randomly and equally between 4 treatments (120 chicks/treatment), and each treatment included 3 replicates, at a rate of (40 chicks/repeat). Chicks were fed on the starter, growth and final diet for up to 6 weeks, and at the end of the experiment, at 42 days old, 12 birds were selected from each treatment at a rate of 4/duplicate treatment. The birds were placed in their kennel within an isolated space in the breeding hall and exposed to a temperature of (36-39-42°C) for 3 hours. The results of the experiment showed a significant increase (P > 0.05) in total protein, albumin, globulin and high-density lipoprotein. The results also showed a significant decrease in cholesterol, LDL, VLDL, GOT enzyme level, sodium and potassium concentration, heterophil cells and the ratio (H/L), and turmeric treatments did not show a significant effect on basal, acidic and monocyte blood cells, and the results indicated a significant increase in the values of PCV and HDL cells. White blood, lymphocytes, chlorine concentration, GSH-PX and CAT enzyme levels in the blood. It can be concluded from this study that the addition of turmeric root powder at a rate of 6.5% has a positive effect on improving some physiological characteristics of broilers exposed to heat stress.
Wo-MENA paradox: glass ceiling or sticky floor?

ABSTRACT Despite the progress made by the countries of the Middle East and North Africa (MENA) region in terms of gender equality and social and, above all, educational emancipation, today there are still disparities in terms of the participation of women in the labour market. This paper proposes a descriptive and qualitative analysis of the situation of women in two MENA countries, which are Algeria and Morocco, and of the socioeconomic factors that hinder their autonomy in the field of work. As a result, the role of the family and the social environment on women is emphasised so that they could be active members of society and consequently become an additional labour force trained for the growth of the region, is emphasised, but it is condemned for the achievement of this triple challenge: education, professional integration, and economic empowerment.
Momentum or Deceleration: The Effect of Previous Change

ABSTRACT A conventional consensus on organizational change is the momentum view, which claims that prior changes of a given kind increase the probability of a subsequent change of the same kind. This consensus has been recently challenged by the deceleration view, which argues that prior changes decrease the probability of a subsequent change. By making a distinction between experienced changes and internalized changes, this study postulates that the two views complement and coexist with each other. A change of a given kind is less likely to occur with more experienced changes of the same kind, while it is more likely to occur with more internalized changes of the same kind. This integrated view is supported in a sample of 477 U.S. local governments making decisions about whether to outsource public services during 1982–2007. This study also looks into how relatedness to internalized changes affected the occurrence of a subsequent change of the same kind. The impact of operational relatedness was positive at an early time and increasingly negative in the long run. The impact of skill relatedness, however, was positive and steadily increased as time went on. MAD statement An important debate on organizational change is how prior changes of a given kind affect the probability of a subsequent change of the same kind. Whereas the momentum view claims that prior changes breed a subsequent change, the deceleration view contends that prior changes prevent a subsequent change. By distinguishing between experienced and internalized changes, this study argues and demonstrates, with a sample of U.S. local governments, that the two views complement and coexist with each other. A change is less likely to occur with more experienced changes, while it is more likely to occur with more internalized changes.
Investigating The Relationship between Writing and Cooperative Learning

When one thinks of “writing”, the vision of a writer silently writing alone to complete a writing assignment comes to mind. Indeed, writing is act of communication between the writer and the reader. One difficulty of the writer is that of physiology difficulty. This difficulty arises when the writer do not feel the interaction and feedback from the readers during the writing process. Some writing activities can help prepare writers to gain interaction while they wrote (even before the intended audience of the written product reads it) is to encourage communication during the writing process. This communication can take place if the writing is not done alone. This study is done to explore the dynamics of cooperative learning in the writing process. In addition to that, this study is also done to show the relationship between writing process and cooperative learning. Learners of academic writing underwent a semester of learning academic writing through activities that support cooperative learning. At the end of the semester, the learners responded to survey to reveal their perceptions of this approach. The instrument used in this study is s survey. The survey has three sections; section A consists of items on demographic profile, section B has 16 items on writing process and section D has 13 items on cooperative learning. Findings showed that group members depend on one another to make the team work a success and this is important for positive interdependence. For a team to succeed, each team members need to be accountable for his/her part. They need to interact well through the use of appropriate interpersonal skills. Only then can the group work towards group processing to improve on the team efforts.
Accurate consideration of metal losses at waveguide junctions using admittance and impedance integral equation formulations

At higher frequencies, metal loss effects in passive waveguide components become more pronounced and hazardous. In this paper, we propose two integral equation techniques, based on the generalized admittance and impedance matrices, for the accurate consideration of losses in the metal walls of waveguide junctions. Both techniques have been evaluated in terms of accuracy and numerical efficiency, and conclusions are drawn regarding the best properties of the admittance parameter formulation. Finally, combining such technique with a classical perturbative method for considering propagation losses, we have successfully predicted all loss effects in two real waveguide filters used for commercial applications.
Effect of Aerobic Exercises on Reduced and Oxidized Glutathione in Aortic Endothelial Cells of Rats Exposed to Arsenic

Background and Aim: Arsenic is an environmental pollutant that can damage tissue by producing free radicals. However, regular aerobic exercise is essential in enhancing antioxidant defense and resistance to oxidative stress. This study aimed to evaluate the effect of aerobic exercise on reduced glutathione (GSH) and oxidized glutathione (GSSG) and aortic endothelial cells of of heart tissue in rats exposed to arsenic. Materials and Methods: In this experimental study, 24 male Wistar rats with a weight ranged 220-240 g and a mean age of 6-8 weeks were divided into 3 groups of 8: healthy control, toxic control, and toxic aerobic exercise. Rats receiving arsenic were prescribed 25 ppm arsenic daily in oral water for 8 weeks. The exercise program consisted of 8 weeks of aerobic exercise, five sessions per week with an intensity of 75%-80% of maximum oxygen consumption. Eventually, 24 hours after the last exercise session, the rats were anesthetized and killed, and the target tissue was removed for examination. The Kolmogorov-Smirnov statistical test and one-way analysis of variance with Tukey post hoc test were used to analyze the findings in SPSS software, version 22 (P≥0.05). Results: Exposure to arsenic significantly reduced GSH and GSSG levels in heart tissue and aortic endothelial cells (P≥0.05). In contrast, aerobic exercise increased GSH and GSSG levels in heart tissue and aortic endothelial cells in arsenic-poisoned rats (P≥0.05). Conclusion: Aerobic exercise effectively reduces oxidative stress and increases antioxidant defense against arsenic toxicity in heart disorders.
Subspace Learning and Empirical Operator Estimation

This work deals with the problem of linear subspace estimation in a general, Hilbert space setting. We provide bounds that are considerably sharper than existing ones, under equal assumptions. These bounds are also competitive with bounds that are allowed to make strong, further assumptions (on the fourth order moments), even when we do not. Finally, we generalize these results to a family of metrics, allowing for a more general denition of performance.
A circularly polarised monopole antenna with switchable frequency, pattern and polarisation

ABSTRACT A compound reconfigurable monopole antenna (CRMA) having ability to change its frequency, polarisation and also pattern is presented in this paper. Only 6 PIN diodes are positioned on the monopole and ground to achieve reconfigurable operations and thus the antenna can operate over 8 different states. The radiation patterns of the proposed antenna can be tilted into two different directions. In each direction, the antenna can shift its operation in between two different frequency bands, and for each band, switching between two orthogonal circularly polarised (CP) radiation can be possible. A prototype is fabricated and measured. Based on various parametric analyses, a simple design guideline is also presented. By considering its overall simple configuration, low profile, and planar geometry, proposed antenna can be a useful candidate for future wireless applications like cognitive radio, 5 G devices, and so on.
Design, Rational Repurposing, Synthesis, In Vitro Evaluation, Homology Modeling and In Silico Study of Sulfuretin Analogs as Potential Antileishmanial Hit Compounds

Direct growth inhibition of infectious organisms coupled with immunomodulation to counteract the immunosuppressive environment might be a beneficial therapeutic approach. Herein, a library of sulfuretin analogs were developed with potential capabilities to inhibit production of the immunosuppressive PGE2 and elicit direct growth inhibition against Leishmania donovani; the major causative agent of the fatal visceral leishmaniasis. Amongst explored library members bearing diverse methoxy and/or hydroxy substitution patterns at rings B and A, analog 1i retaining the C6-hydroxy moiety at ring-A, but possessing methoxy moieties in place of the polar dihydroxy moieties of sulfuretin ring-B, as well as analog 1q retaining the sulfuretin′s polar dihydroxy moieties at ring-B, but incorporating a C6-methoxy moiety instead of the C6-hydroxy moiety at ring-A, were the most promising hit compounds. Cytotoxicity evaluation suggested that analog 1i possesses a safety profile inducing the death of the parasite rather than host cells. In silico simulation provided insights into their possible binding with Leishmania donovani fumarate reductase. The current investigation presents sulfuretin analogs 1i and 1q as potential hit compounds for further development of multifunctional therapeutic agents against visceral leishmaniasis.
Collective mode of homogeneous superfluid Fermi gases in the BEC-BCS crossover (14 pages)

We perform a detailed study of the collective mode across the whole crossover from the Bose-Einstein condensate (BEC)-to the BCS regime in fermionic gases at zero temperature, covering the whole range of energy beyond the linear regime. This is done on the basis of the dynamical BCS model. We recover first the results of the linear regime in a simple form. Then specific attention is paid to the nonlinear part of the dispersion relation and its interplay with the continuum of single-fermionic excitations. In particular we consider in detail the merging of the collective mode into the continuum of single-fermionic excitations. This occurs not only on the BCS side of the crossover, but also slightly beyond unitarity on the BEC side. Another remarkable feature is the very linear behavior of the dispersion relation in the vicinity of unitarity almost up to merging with the continuum. Finally, while on the BEC side the mode is quite analogous to the Bogoliubov mode, a difference appears at high wave vectors. On the basis of our results we determine the Landau critical velocity in the BEC-BCS crossover which is found to be largest close to unitarity. Our investigation has revealed interesting qualitative features whichmore » deserve experimental exploration as well as further theoretical studies by more sophisticated means. « less
Anisotropic SpiralNet for 3D Shape Completion and Denoising

Three-dimensional mesh post-processing is an important task because low-precision hardware and a poor capture environment will inevitably lead to unordered point clouds with unwanted noise and holes that should be suitably corrected while preserving the original shapes and details. Although many 3D mesh data-processing approaches have been proposed over several decades, the resulting 3D mesh often has artifacts that must be removed and loses important original details that should otherwise be maintained. To address these issues, we propose a novel 3D mesh completion and denoising system with a deep learning framework that reconstructs a high-quality mesh structure from input mesh data with several holes and various types of noise. We build upon SpiralNet by using a variational deep autoencoder with anisotropic filters that apply different convolutional filters to each vertex of the 3D mesh. Experimental results show that the proposed method enhances the reconstruction quality and achieves better accuracy compared to previous neural network systems.