Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of the changes in cardiac sympathetic nervous activity using the pupil size changes measured in seated patients whose stellate ganglion is blocked by interscalene brachial plexus block

Background As a side effect of interscalene brachial plexus block (ISBPB), stellate ganglion block (SGB) causes reductions in pupil size (Horner’s syndrome) and cardiac sympathetic nervous activity (CSNA). Reduced CSNA is associated with hemodynamic instability when patients are seated. Therefore, instantaneous measurements of CSNA are important in seated patients presenting with Horner’s syndrome. However, there are no effective tools to measure real-time CSNA intraoperatively. To evaluate the usefulness of pupillometry in measuring CSNA, we investigated the relationship between pupil size and CSNA. Methods Forty-two patients undergoing right arthroscopic shoulder surgery under ISBPB were analyzed. Pupil diameters were measured at 30 Hz for 2 s using a portable pupillometer. Bilateral pupil diameters and CSNA (natural-log-transformed low-frequency power [0.04–0.15 Hz] of heart rate variability [lnLF]) were measured before ISBPB (pre-ISBPB) and 15 min after transition to the sitting position following ISBPB (post-sitting). Changes in the pupil diameter ([right pupil diameter for post-sitting – left pupil diameter for post-sitting] – [right pupil diameter for pre-ISBPB – left pupil diameter for pre-ISBPB]) and CSNA (lnLF for post-sitting – lnLF for pre-ISBPB) were calculated. Results Forty-one patients (97.6%) developed Horner’s syndrome. Right pupil diameter and lnLF significantly decreased upon transition to sitting after ISBPB. In the linear regression model (R2 = 0.242, P = 0.001), a one-unit decrease (1 mm) in the extent of changes in the pupil diameter reduced the extent of changes in lnLF by 0.659 ln(ms2/Hz) (95% CI [0.090, 1.228]). Conclusions Pupillometry is a useful tool to measure changes in CSNA after the transition to sitting following ISBPB.
Does Upward Social Comparison on SNS Inspire Adolescent Materialism? Focusing on the Role of Self-Esteem and Mindfulness

Abstract The present study tested the mediating role of self-esteem and the moderating role of mindfulness in the association between upward social comparison on social network sites (SNSs) and adolescent materialism. A sample of 880 Chinese adolescents completed measures of upward social comparison on SNSs, materialism, self-esteem, mindfulness, and demographic information. Results showed that self-esteem mediated the link between upward social comparison on SNSs and adolescent materialism. That is, upward social comparison on SNSs was positively associated with adolescent materialism through the decreased self-esteem. Moreover, mindfulness acted as an important moderator in the mediation model. Both the direct association between upward social comparison on SNSs and materialism and the indirect association via self-esteem were moderated by mindfulness. These two associations were both weaker for adolescents with higher mindfulness than for those with lower mindfulness. These findings would advance our understanding of how and when upward social comparison on SNSs is associated with adolescent materialism. Limitations and implications of the present study are discussed.
Acute Promyelocytic Leukemia in a Woman with Thalassemia Intermedia: Case Report and Review of Literature on Hematological Malignancies in β-Thalassemia Patients

Patients affected by transfusion-dependent β-thalassemia are prone to developing several clinical complications, mostly related to the iron overload. We report the case of a patient affected by transfusion-dependent β-thalassemia (TDT) developing acute promyelocytic leukemia (APL). In our case, the therapeutic management was significantly complicated not only by myocardial dysfunction, but also by the occurrence of the differentiation syndrome following all-trans retinoic acid (ATRA) administration. We carried out a careful revision of the current literature on the occurrence of hematological malignancies in β-thalassemia patients to investigate the major complications so far described. APL occurrence in β-thalassemia patients has been very rarely reported, and our experience suggests that TDT patients suffering pre-existing comorbidities may develop a potentially fatal complication during ATRA therapy.
Evaluation of Orbitomalar Region Projection in Patients With Operated Cleft Lip and Palate (Cephalometric Study)

Objective The aim of this study was to compare the orbitomalar region projection in patients with cleft lip and palate (CLP) with skeletal class 1 cases. Design Retrospective. Setting Single center. Patients Cephalometric data of 52 cases with unilateral CLP, 25 cases with bilateral CLP, and 60 healthy participants in skeletal class 1 without CLP were included. Main Outcome Measure(s) A total of 5 parameters, 3 in the orbital and 2 in the suborbital region, that determine the projection of the orbitomalar region on lateral cephalograms, and 13 parameters of the craniofacial region were evaluated. Results Lateral, inferior, and anterior orbital parameters were similar between groups, while suborbital parameters were in a retrusive position in the CLP groups compared to the control group (P < .05). No significant difference was found between the CLP groups in terms of suborbital parameters. A moderate positive correlation was found between orbitomalar parameters and the anteroposterior positions of the maxilla and mandible. The lateral orbital region had a moderate negative correlation with anterior maxillary height, and the suborbital region had a negative moderate correlation with maxillary inclination. Conclusion Suborbital projection was more retrusive in CLP compared to the control group, but no difference was found between the CLP groups. On the other hand, the correlation between orbitomalar projection and maxillary and mandibular development was significant. The results show that there is a need for alternative treatment modalities for the suborbital region in patients with CLP.
Quantitative vascular outgrowth and anatomic and refractive outcomes of eyes treated with bevacizumab in posterior zone Ⅰ

Purpose To report the anatomic and refractive outcomes and retinal vascular outgrowth in eyes with posterior zone Ⅰ retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IVB). Methods Thirty-eight eyes of 21 infants treated with IVB for type 1 and aggressive-ROP, and whose posterior border of retinal vascularization was shorter than the optic disc-to-fovea distance were defined as posterior zone Ⅰ and included in the study. Results Nine eyes of five infants whose follow-up time was lower than four months were accepted as insufficient for clinical outcomes. Additional treatment(s) had been performed up to 60 weeks postmenstrual age (PMA) in 10 of 29 eyes whose follow-up were higher than four months. Macula was attached at the final examination in all eyes with > 4 months follow-up. Anatomical outcome of two eyes of one infant was accepted as unfavorable whose routine follow-up was interrupted after successful initial treatment and who was presented with straightening of the temporal vascular arcade and residual fibrovascular tractional bands on the temporal periphery. The mean progression of temporal retinal vascularization was 3.6 ± 2.0 horizontal disc diameters (DD) within 7.3 weeks and 5.1 ± 2.5 horizontal DD within 69.1 weeks in the short-term (n=15) and long-term evaluated eyes (n=21), respectively. The mean spherical equivalent was −4.1 diopters at a mean age of 21 months (n=28). Conclusions A favorable outcome had been achieved in almost all bevacizumab-treated eyes, but additional treatments were required. Significant progression of retinal vascularization was detected even in the eyes with short follow-up.
Associations Between Adolescent Problematic Internet Use and Relationship Problems in Chinese Families: Findings from a Large-scale Survey

Background Problematic internet use (PIU) is prevalent among Chinese adolescents. There is a need to better understand how the quality of parent-adolescent relationship is associated with adolescent PIU to guide the development of effective prevention and early intervention programs. Objective This study aims to evaluate parent-adolescent conflict and parenting styles as potential risk factors associated with adolescent PIU. Methods A sample of 6552 students (aged 10-19 years) from 22 schools in Guangdong, China, was recruited. The participants completed self-report questionnaires measuring their perceptions of conflict with their parents (involving verbal conflict, emotional abuse, and physical abuse) as well as their perceptions of their parents’ parenting styles (including parental care and parental control as measured by the Parental Bonding Inventory), and PIU using the Adolescent Pathological Internet Use Scale. Grade level and gender were examined as moderators of these associations. Results Using multiple regression analyses, we found that greater mother-adolescent conflict, father-adolescent conflict, and parental control, and lower levels of parental care, were associated with higher levels of adolescent PIU (P<.001). The association between mother-adolescent conflict and PIU was stronger in older students than in younger students (P=.04), whereas the association between father-adolescent conflict and PIU was stronger in male students than in female students (P=.02). Compared with those who reported no mother-adolescent conflict, participants who experienced verbal conflict and emotional abuse, but not physical abuse from their mothers, reported higher levels of PIU (P<.001). Compared with those who reported no father-adolescent conflict, participants who experienced verbal conflict, emotional abuse, and physical abuse from their fathers had significantly higher levels of PIU (P<.001, P<.001, and P=.02, respectively). Conclusions These findings point to the value of interventions to reduce parental verbal conflict, emotional abuse, and physical abuse, and to increase positive parenting styles, to lower the risk of PIU in Chinese adolescents.
COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics

This article reports on an American Society of Pharmacology and Therapeutics, Division of Drug Metabolism and Disposition symposium held at Experimental Biology on April 2, 2022, in Philadelphia. As of July 2022, over 500 million people have been infected with SARS-CoV-2 (the virus causing COVID-19) and over 12 billion vaccine doses have been administered. Clinically significant interactions between viral infections and hepatic drug metabolism were first recognized over 40 years ago during a cluster of pediatric theophylline toxicity cases attributed to reduced hepatic drug metabolism amid an influenza B outbreak. Today, a substantive body of research supports that the activated innate immune response generally decreases hepatic cytochrome P450 activity. The interactions extend to drug transporters and other organs and have the potential to impact drug absorption, distribution, metabolism, and excretion (ADME). Based on this knowledge, altered ADME is predicted with SARS-CoV-2 infection or vaccination. The report begins with a clinical case exploring the possibility of SARS-CoV-2 vaccination increasing clozapine levels. This is followed by discussions of how SARS-CoV-2 infection or vaccines alter the metabolism and disposition of complex drugs, such as nanoparticles and biologics and small molecule therapies. The review concludes with a discussion of the effects of viral infections on placental amino acid transport and their potential to impact fetal development. The session improved our understanding of the impact of emerging viral infections and vaccine technologies on drug metabolism and disposition, which will help mitigate drug toxicity and improve drug and vaccine safety and effectiveness. SIGNIFICANCE STATEMENT Altered pharmacokinetics of small molecule and complex molecule drugs and fetal brain distribution of amino acids following SARS-CoV-2 infection or immunization are possible. The proposed mechanisms involve decreased liver cytochrome P450 metabolism of small molecules, enhanced innate immune system metabolism of complex molecules, and altered placental and fetal blood-brain barrier amino acid transport, respectively. Future research is needed to understand the effects of these interactions on adverse drug responses, drug and vaccine safety, and effectiveness and fetal neurodevelopment.
Perception of Nurses’ Knowledge about Palliative Care in West Bank/ Palestine: Levels and Influencing Factors

Objective: Healthcare professionals particularly nurses should be professionally prepared with knowledge about the standards of palliative care and their roles in providing palliative care. Nurses’ knowledge about palliative care and influencing factors has not been examined adequately in Arab countries including Palestine. Thus, this study aimed to assess the adequacy of knowledge level and influencing factors (socio-demographic) about palliative care among nurses in West Bank/ Palestine. Methods: A descriptive-correlational design was utilized. A cluster random sampling method was applied to select 12 hospitals from the three regions in West Bank. Then, four hospitals were selected from each region using a simple random method. All registered nurses working in critical care units and medical and surgical wards in the selected hospitals were recruited. The sample consists of 424 registered nurses and data were collected using Palliative Care Quiz for Nursing (PCQN). Results: The Findings revealed that nurses’ level of knowledge about palliative care was low/inadequate (M = 7.75, SD = 2.96). Knowledge about palliative care was influenced by age (B = −.106; p < 0.05), gender (B = −.223; p < 0.001), and hospital ward (B = −.597; p < 0.001), in which younger nurses, females, and those who work in critical care units reported higher levels of knowledge about palliative care. Conclusions: Findings of this study emphasized the need for developing educational and training courses, seminars, and workshops on palliative care to increase nurses’ knowledge in order to enhance the quality of patient care. Also, policymakers should develop national strategic plans and policies regarding palliative care and apply these plans in all hospitals in West Bank/ Palestine.
An exploration of LAF‐bTMB as a predictor for the efficacy of immunotherapy combined with chemotherapy in non—small cell lung cancer

Immune checkpoint inhibitor (ICI) combined with chemotherapy is one of the standards of care for advanced non–small cell lung cancer (NSCLC) without driver mutations. However, the biomarker of combination therapy is still unknown. Although previous studies have confirmed that low allele frequency adjusted blood‐based tumor mutational burden (LAF‐bTMB) is associated with the efficacy of ICI monotherapy, there has been no report on the correlation between the efficacy of LAF‐bTMB and ICI combined chemotherapy. This study aimed to explore whether LAF‐bTMB can be used as a predictive biomarker for the efficacy of immunotherapy combined with chemotherapy in advanced NSCLC.
Antioxidant, immunomodulatory, and anti-inflammatory effects of Spirulina in disease conditions: a systematic review

Abstract The goal of this review was to critically evaluate the research on the effects of Spirulina (SP) supplementation on pathological conditions in the general population, considering its antioxidant, immunomodulatory, and anti-inflammatory properties. On a total of 1621 records screened, eighteen studies published between 2001 and 2020 met the inclusion criteria. Despite variability in research methodology and patient conditions, the findings of these studies generally support the benefits of supplementing diet with SP in subjects with both transmittable and non-transmittable diseases. Improvements were found for all the conditions studied, with the only exception of male infertility. However, the number of clinically controlled trials examining the effects of SP on specific health conditions is still very low, and some studies show medium quality. Further research in this field is needed to confirm the possible clinical role of Spirulina supplementation in parallel with medical therapies.
The kilohertz quasi-periodic oscillations during the Z and atoll phases of the unique transient XTE J1701−462

We analysed 866 observations of the neutron star low-mass X-ray binary XTE J1701-462 during its 2006-2007 outburst. XTE J1701-462 is the only example so far of a source that during an outburst showed, beyond any doubt, spectral and timing characteristics both of the Z and atoll type. There are 707 RXTE observations (similar to 2.5 Ms) of the source in the Z phase and 159 in the atoll phase (similar to 0.5 Ms). We found, respectively, pairs of kilohertz quasi-periodic oscillations (kHz QPOs) in eight observations during the Z phase and single kHz QPO in six observations during the atoll phase. Using the shift-and-add technique, we identified the QPO in the atoll phase as the lower kHz QPO. We found that the lower kHz QPO in the atoll phase has a significantly higher coherence and fractional rms amplitude than any of the kHz QPOs seen during the Z phase, and that in the same frequency range, atoll lower kHz QPOs show coherence and fractional rms amplitude, respectively, two and three times larger than the Z kHz QPOs. Out of the 707 observations in the Z phase, there is no single observation in which the kHz QPOs have a coherence or rms amplitude similar to those seen when XTE J1701-462 was in the atoll phase, even though the total exposure time was about five times longer in the Z than in the atoll phase. Since it is observed in the same source, the difference in QPO coherence and rms amplitude between the Z and atoll phase cannot be due to neutron star mass, magnetic field, spin, inclination of the accretion disc, etc. If the QPO frequency is a function of the radius in the accretion disc in which it is produced, our results suggest that in XTE J1701-462 the coherence and rms amplitude are not uniquely related to this radius. Here we argue that this difference is instead due to a change in the properties of the accretion flow around the neutron star. Regardless of the precise mechanism, our result shows that effects other than the geometry of space-time around the neutron star have a strong influence on the coherence and rms amplitude of the kHz QPOs, and therefore the coherence and rms amplitude of the kHz QPOs cannot be simply used to deduce the existence of the innermost stable circular orbit around a neutron star.
The role of environment in the observed Fundamental Plane of radio active galactic nuclei

The optical Fundamental Plane of black hole activity relates radio continuum luminosity of active galactic nuclei (AGNs) to [OⅠⅠⅠ] luminosity and black hole mass. We examine the environments of low-redshift (𝓏 < 0.2) radio-selected AGNs, quantified through galaxy clustering, and find that halo mass provides similar mass scalings to black hole mass in the Fundamental Plane relations. AGN properties are strongly environment-dependent: massive haloes are more likely to host radiatively inefficient (low-excitation) radio AGN, as well as a higher fraction of radio luminous, extended sources. These AGN populations have different radio-optical luminosity scaling relations, and the observed mass scalings in the parent AGN sample are built up by combining populations preferentially residing in different environments. Accounting for environment-driven selection effects, the optical Fundamental Plane of supermassive black holes is likely to be mass-independent, as predicted by models.
Intergenerational Transmission of Depression during Adolescence: The Mediating Roles of Hostile Attribution Bias, Empathic Concern, and Social Self-Concept

Abstract Few studies have empirically examined the role of peer microsystem in the intergenerational transmission of depression, and more importantly, little is known about the mechanisms underlying this potential pathway of intergenerational transmission. The purpose of the current study was to examine the sequential mediation effects of adolescent hostile attribution bias, empathic concern, and social self-concept on the association between maternal depression and adolescent depression. An urban Chinese sample of 761 mother-child dyads was investigated when the adolescents were in secondary school (M = 14.36 years, range =12.33–16.92 years, 52.3% female). The results provided evidence of cross-generational continuity in depression during adolescence, and the hypothesized sequential mediation model was supported. The findings highlight the importance of peer-related factors during the intergenerational transmission of depression and have important implications for interpersonal interventions that aim to prevent depression during adolescence. The limitations of the study and suggestions for future research are briefly discussed.
Primordial non-Gaussianity, statistics of collapsed objects, and the integrated Sachs-Wolfe effect

Any hint of non-Gaussianity in the cosmological initial conditions will provide us with a unique window into the physics of the early Universe. We show that the impact of a small local primordial non-Gaussianity (generated on superhorizon scales) on the statistics of collapsed objects (such as galaxies or clusters) can be approximated by using slightly modified, but Gaussian, initial conditions, which we describe through simple analytic expressions. Given that numerical simulations with Gaussian initial conditions are relatively well studied, this equivalence provides us with a simple tool to predict signatures of primordial non-Gaussianity in the statistics of collapsed objects. In particular, we describe the predictions for non-Gaussian mass function, and also confirm the recent discovery of a nonlocal bias on large scales [N. Dalal, O. Dore, D. Huterer, and A. Shirokov, Phys. Rev. D 77, 123514 (2008). ][S. Matarrese and L. Verde, Astrophys. J. 677, L77 (2008). ], as a signature of primordial non-Gaussianity. We then study the potential of galaxy surveys to constrain non-Gaussianity using their autocorrelation and cross correlation with the cosmic microwave background (CMB) (due to the integrated Sachs-Wolfe effect), as a function of survey characteristics, and predict that they will eventually yield an accuracy of $\ensuremath{\Delta}{f}_{NL}\ensuremath{\sim}0.1$ and 3, respectively, which will be better than or competitive with (but independent of) the best predicted constraints from the CMB. Interestingly, the cross correlation of the CMB and the NRAO VLA Sky Survey galaxy survey already shows a hint of a large local primordial non-Gaussianity: ${f}_{NL}=236\ifmmode\pm\else\textpm\fi{}127$.
Circulating plasma miR222‐3P status and its potential diagnostic performance in prostate cancer

Although studies suggest that miR222‐3p is dysregulated in prostate cancer (PC) cells and tissues, the possible changes in the level of miR222‐3p in the plasma samples of PC patients remained unclear. The present study aimed to evaluate the diagnostic value of the plasma miR222‐3p expression level as a potential biomarker in PC, benign prostatic hyperplasia (BPH) and healthy people.