Miracle-dz/UniFAR-FTUs huggingface dataset:
Small-Sided Games in Elite Football: Practical Solutions to Replicate the 4-min Match-Derived Maximal Intensities

Supplemental Digital Content is Available in the Text. Abstract Riboli, A, Esposito, F, and Coratella, G. Small-sided games in elite football: practical solutions to replicate the 4-min match-derived maximal intensities. J Strength Cond Res 37(2): 366–374, 2023—The purpose of the study was to determine the area per player (ApP, m2·player−1) to replicate the maximal 4-min match-play period (4-minPeak) using small-sided or large-sided games (SSGs) lasting the same duration in elite football players. Twenty players (age: 26 ± 5 years) competing in European championship and international UEFA competitions were monitored during SSGs with (SSGwith) or without (SSGwithout) goalkeepers, both lasting 4-min. A total of 1,724 and 561 individual observations for SSGwith and SSGwithout across 99 and 34 different SSGs formats were undertaken. Whole (90-minavg) and 4-minPeak match demands were calculated. Relative (m·min−1) total, high-speed (HSRD), very high-speed (VHSRD), sprint, and acceleration/deceleration distance were collected. For both SSGwith and SSGwithout, ApP was small-to-very-largely correlated with TD, HSRD, VHSRD, and sprint, whereas an inverse trivial-to-small correlation with acceleration/deceleration was found. In SSGwith, the ApP to replicate 4-minPeak was larger (p < 0.001, effect size [ES]: 0.33–5.80) than that to mimic 90-minavg for total distance, HSRD, VHSRD, and sprint, whereas for acceleration/deceleration the ApP was lower (p < 0.001, ES: −3.13 to 0.48) for 4-minPeak. In SSGwithout, the ApP to replicate 4-minPeak was larger (p < 0.001, ES: 0.04–3.72) than that to mimic 90-minavg for HSRD, VHSRD, and sprint. Some positional differences (p < 0.05, ES: 0.22–1.10) in ApP were found. The ApP to replicate 4-minPeak was higher for SSGwith than SSGwithout (p < 0.001, ES: 0.67–3.58). These findings may help practitioners to recreate the 4-minPeak to manage ApP during SSGs in elite football.
Longitudinal associations between stress and sleep disturbances during COVID‐19

Abstract The psychological consequences of COVID‐19 pandemic may include the activation of stress systems, that involve the hypothalamic‐pituitary‐adrenal axis which influences many physiological functions, including sleep. Despite epidemiological studies evidenced greater prevalence of stress symptoms and sleep disturbances during COVID‐19, longitudinal evidence investigating the effects of stress on sleep disturbances during the pandemic is lacking. We collected measures of perceived stress and sleep disturbances during the first wave of COVID‐19 (March 2020) and at 8–10 months follow up in a sample of 648 adults (M = 33.52, SD = 12.98 years). Results showed that 39.4% of participants reported moderate to extremely severe stress in March 2020. Prevalence of sleep disturbances was 54.8% in March 2020 and 57.4% at follow‐up. Structural equation modelling highlighted that perceived stress in March 2020 significantly predicted sleep disturbances at follow up (β = 0.203; p < 0.001), even after controlling for baseline sleep disturbances. Results remained significant even after controlling for the effects of covariates including age, sex, depression and anxiety symptoms, and referring to psychological services (β = 0.179; p < 0.05). Findings confirm the high prevalence of stress symptoms during the COVID‐19 pandemic and provide first longitudinal evidence for the effects of perceived stress on sleep disturbances during the pandemic.
A network perspective on abnormal child behavior in primary school students

Abnormal child behavior is a complex entity including among others disorders such as ADHD, a neuropsychiatric disorder interfering with the normal development of the child, and combining many comorbidities. There are no specific tools designed to assess abnormal child behavior, although well-known ADHD screening tools such as the CTRS-R:S go beyond the disorder itself and cover the wider construct. This can be understood as the complex system of mutually influencing entities, that is why the aim of this study was to investigate the items of the CTRS-R:S as a psychological network. We analyzed a data set of 525 children in French-speaking primary schools from Belgium, and estimated a Bayesian Gaussian Graphical Model with a Bayes Factor of 30. We identified highly connected nodes from each community of the CTRS-R:S to build an additional network of communities. In the domain network, Oppositional and Cognitive skills share the strongest connection in the network. The 28-item network was overall positively connected albeit the presence of some negative connections. The spinglass algorithm identified eight domains in the CTRS-R:S network that causally influence each other. The network approach is a useful framework to investigate the domains of abnormal child behavior as well as the interplay between individual symptoms.
Extent of mural thrombus is not associated with increased 5-year mortality following elective AAA repair

Background Mural thrombus in abdominal aortic aneurysm (AAA) has been associated with increased rates of aneurysm growth as well as adverse cardiovascular events. The extent of mural thrombus in thoracoabdominal aortic aneurysms has recently been linked to 1-year mortality following endovascular repair and has been hypothesized as a marker for reduced cardiac reserve. This study investigates whether the extent of mural thrombus in infra-renal AAA is associated with 5-year mortality following elective repair. Methods Retrospective review of all patients undergoing elective infra-renal AAA repair at a single academic medical center between 2007 and 2016 was performed. The following variables at the time of surgery were investigated for association with 5-year mortality: age, sex, ethnicity, insurance status and co-morbidities, repair type, renal insufficiency, end-stage renal disease on dialysis, history of smoking, coronary artery disease, congestive heart failure, diabetes mellitus, hypertension, stroke, chronic obstructive pulmonary disease, body mass index category, AAA diameter, and ratio of aortic thrombus to total aneurysm diameter. Results Amongst 427 patients undergoing infra-renal AAA repair during the study period, 232 met extensive inclusion criteria. Univariate analysis found mean age (76 vs 72, p < 0.01), age cohort over 72 years (OR = 1.9, p = 0.04), renal insufficiency (OR = 3.1, p < 0.01), ESRD (OR = 6.5, p < 0.01), AAA diameter 6 cm or greater (OR = 2.3, p < 0.01), and mean AAA diameter (61.36 vs 56.99 mm, p < 0.01) all predictive of 5-year mortality. Multivariate analysis revealed renal insufficiency (p < 0.01) and AAA diameter 6 cm or greater (p = 0.03) to be significantly associated with 5-year mortality. The extent of mural thrombus was identical between 5-year survivors and non-survivors. The mean inner to outer AAA diameter was 0.65 in the survivor cohort and 0.64 in the mortality cohort. Inner to outer ratio of < 0.5 was identified in 23% of 5-year survivors and 27% of the mortality group. Conclusions In our experience, the extent of mural thrombus in AAA does not influence long-term survival after elective repair. AAA repair may provide protection against circulating components of mural thrombus which have the potential to promote atherosclerotic-related adverse events. Patients with renal insufficiency and larger AAA have increased risk of mortality 5 years after elective repair.
Prescription of Blood Lymphocyte Immunophenotyping in the Diagnosis of Lymphoid Neoplasms in Older Adults

Lymphoid neoplasms are a heterogeneous group of lymphoid neoplastic diseases with multiple presentations, and varying prognoses. They are especially frequent in older patients (OPs) and the atypism of this frail elderly population can make the diagnostic process even more difficult. Blood lymphocyte immunophenotyping (BLI) is essential in rapid noninvasive diagnosis orientation and guides complementary investigations. To our knowledge, BLI prescription has never been evaluated in OPs. We hypothesized that, when there is a suspicion of lymphoid neoplasm in the geriatric population, a BLI is performed in view of various clinical or biological abnormalities. This study aimed to: (1) describe the characteristics of hospitalized OPs having undergone BLI for suspected lymphoid neoplasm, (2) identify the causes leading to BLI prescription, and (3) identify the most profitable criteria for BLI prescription. This was a descriptive retrospective study on 151 OPs aged ≥75 years who underwent BLI over a 2-year period. Regarding BLI prescriptions, eight had lymphocytosis, constituting the “lymphocytosis group” (LG+), while the 143 others had BLI prescribed for reasons other than lymphocytosis (LG−), mainly general weakness and anemia. In the LG−, we compared OPs with positive and negative BLI results. The criteria found to be profitable for BLI prescription were lymphadenopathy, splenomegaly, lymphocytosis, and thrombocytopenia. BLI identified circulating lymphoid neoplasms (positive BLI) in 21/151 OPs, mainly marginal zone lymphoma and chronic lymphocytic leukemia. In polymorbid OPs, as per our study population, the diagnostic and therapeutic complexity explained in part the sole use of indirect and minimally invasive diagnostic techniques such as BLI.
Krüppel-like Transcription Factor 7 Is a Causal Gene in Autism Development

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disease. To date, more than 1000 genes have been shown to be associated with ASD, and only a few of these genes account for more than 1% of autism cases. Klf7 is an important transcription factor of cell proliferation and differentiation in the nervous system, but whether klf7 is involved in autism is unclear. Methods: We first performed ChIP-seq analysis of klf7 in N2A cells, then performed behavioral tests and RNA-seq in klf7+/− mice, and finally restored mice with adeno-associated virus (AAV)-mediated overexpression of klf7 in klf7+/− mice. Results: Klf7 targeted genes are enriched with ASD genes, and 631 ASD risk genes are also differentially expressed in klf7+/− mice which exhibited the core symptoms of ASD. When klf7 levels were increased in the central nervous system (CNS) in klf7+/− adult mice, deficits in social interaction, repetitive behavior and majority of dysregulated ASD genes were rescued in the adults, suggesting transcriptional regulation. Moreover, knockdown of klf7 in human brain organoids caused dysregulation of 517 ASD risk genes, 344 of which were shared with klf7+/− mice, including some high-confidence ASD genes. Conclusions: Our findings highlight a klf7 regulation of ASD genes and provide new insights into the pathogenesis of ASD and promising targets for further research on mechanisms and treatments.
Monochromatic <i>K<sub>r</sub></i>#x02010;Decompositions of Graphs

Given graphs G and H, and a coloring of the edges of G with k colors, a monochromatic H-decomposition of G is a partition of the edge set of G such that each part is either a single edge or forms a monochromatic graph isomorphic to H. Let φk (n, H ) be the smallest number φ such that any graph G of order n and any coloring of its edges with k colors, admits a monochromatic H-decomposition with at most φ parts. Here, we study the function φk (n, Kr ) for k ≥ 2 and r ≥ 3. C © 2013 Wiley Periodicals, Inc. J. Graph Theory
Meta‐analysis of the antifungal activities of three essential oils as alternative therapies in dermatophytosis infections

This work examines the available scientific evidence about the efficiency of essential oils (EO) as an alternative therapy to traditional treatment of fungal infections, including onychomycosis, assessing the effect of the three EO most frequently studied for their antifungal activity (thyme, cinnamon and tea tree EO) against three causative agents of fungal diseases in humans: Trichophyton rubrum, Trichophyton mentagrophytes complex and Candida albicans.
MetaSquare: an integrated metadatabase of 16S rRNA gene amplicon for microbiome taxonomic classification

MOTIVATION Taxonomic classification of 16S ribosomal RNA gene amplicon is an efficient and economic approach in microbiome analysis. 16S rRNA sequence databases like SILVA, RDP, EzBioCloud, and HOMD used in downstream bioinformatic pipelines have limitations on either the sequence redundancy or the delay on new sequence recruitment. To improve the 16S rRNA gene-based taxonomic classification, we merged these widely used databases and a collection of novel sequences systemically into an integrated resource. RESULTS MetaSquare version 1.0 is an integrated 16S rRNA sequence database. It is composed of more than six million sequences and improves taxonomic classification resolution on both long-read and short-read methods. AVAILABILITY Accessible at https://hub.docker. com/r/lsbnb/metasquare_db and https://github.com/lsbnb/MetaSquare. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Genetic Testing and FOX News

aDepartment of Renal Medicine, University College London, London, UK; bKidney Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; cDepartments of Medicine, Pharmacology and Physiology, University of Montreal and Nephrology Service, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada Received: January 7, 2022 Accepted: January 18, 2022 Published online: March 24, 2022
Attention to Speech and Music in Young Children with Bilateral Cochlear Implants: A Pupillometry Study

Early bilateral cochlear implants (CIs) may enhance attention to speech, and reduce cognitive load in noisy environments. However, it is sometimes difficult to measure speech perception and listening effort, especially in very young children. Behavioral measures cannot always be obtained in young/uncooperative children, whereas objective measures are either difficult to assess or do not reliably correlate with behavioral measures. Recent studies have thus explored pupillometry as a possible objective measure. Here, pupillometry is introduced to assess attention to speech and music in noise in very young children with bilateral CIs (N = 14, age: 17–47 months), and in the age-matched group of normally-hearing (NH) children (N = 14, age: 22–48 months). The results show that the response to speech was affected by the presence of background noise only in children with CIs, but not NH children. Conversely, the presence of background noise altered pupil response to music only in in NH children. We conclude that whereas speech and music may receive comparable attention in comparable listening conditions, in young children with CIs, controlling for background noise affects attention to speech and speech processing more than in NH children. Potential implementations of the results for rehabilitation procedures are discussed.
Past accomplishments and future challenges of the multi-omics characterization of leaf growth

Abstract The advent of omics technologies has revolutionized biology and advanced our understanding of all biological processes, including major developmental transitions in plants and animals. Here, we review the vast knowledge accumulated concerning leaf growth in terms of transcriptional regulation before turning our attention to the historically less well-characterized alterations at the protein and metabolite level. We will then discuss how the advent of biochemical methods coupled with metabolomics and proteomics can provide insight into the protein–protein and protein–metabolite interactome of the growing leaves. We finally highlight the substantial challenges in detection, spatial resolution, integration, and functional validation of the omics results, focusing on metabolomics as a prerequisite for a comprehensive understanding of small-molecule regulation of plant growth.
Long duration advertisement calls of nesting male plainfin midshipman fish are honest indicators of size and condition.

The plainfin midshipman fish (Porichthys notatus) has long served as a model organism for neuroethology research on acoustic communication and related social behaviors. Type I or "singing" males produce highly stereotyped, periodic advertisement calls that are the longest known uninterrupted vertebrate vocalizations, lasting up to two hours in duration. Despite the extensive literature on the acoustic behaviour of this species, it remains unclear whether reproductive males signal their quality via their highly energetic, multiharmonic advertisement calls. Here, we recorded the advertisement calls of 22 reproductive type I males at night in a controlled laboratory setting in which males were housed in artificial tanks maintained at a constant temperature (13.9+0.3°C). The duration of the advertisement calls from type I males was observed to increase from the first call of the night to the middle call after which call duration remained steady until the early morning hours and first light. A strong positive correlation was observed between loudness (SPL and maximum SPL) of the advertisement call and body size (mass and standard length; rs>0.8). In addition, an asymptotic relationship was observed between the harmonic frequencies (F0-F10) of the advertisement calls and male body condition, with harmonic frequencies initially increasing with body condition but then plateauing at higher body condition. Taken together, our results suggest that type I male advertisement calls provide reliable honest information about male quality regarding size and body condition. Such condition dependent information of calling males could potentially be used by receptive females to help facilitate mate choice decisions.
Family experiences of in-hospital end-of-life care for adults: A systematic review of qualitative evidence.

AIM To systematically identify, appraise, aggregate and synthesise qualitative evidence on family members' experiences of end-of-life care (EoLC) in acute hospitals. METHODS A systematic review and qualitative evidence synthesis based on the Joanna Briggs Institute methodology. Primary research, published 2014 onwards was identified using a sequential strategy of electronic and hand searches. Six databases (CINAHL, Medline, Embase, EMCare, PsycINFO, BNI) were systematically searched. Studies that met pre-determined inclusion/exclusion criteria were uniformly appraised using the Critical Appraisal Skills Programme checklist for qualitative research, and synthesised using a meta-aggregative approach. The ENTREQ statement was used as a checklist for reporting the review. RESULTS Sixteen studies of European, Australasian and North American origin formed the review. The quality of each study was considered very good in view of a 'yes' response to most screening questions. Extracted findings were assembled into 12 categories, and five synthesised findings: Understanding of approaching end of life; essential care at the end of life; interpersonal interactions; environment of care; patient and family care after death. CONCLUSION Enabling and improving peoples' experience of EoLC must remain part of the vision and mission of hospital organisations. Consideration must be given to the fulfilment of family needs and apparent hallmarks of quality care that appear to influence experiential outcomes. RELEVANCE TO CLINICAL PRACTICE This review of qualitative research represents the first-stage development of a family-reported experience measure for adult EoLC in the hospital setting. The synthesised findings provide a Western perspective of care practices and environmental factors that are perceived to impact the quality of the care experience. Collectively, the review findings serve as a guide for evidence-informed practice, quality improvement, service evaluation and future research. A developed understanding of the families' subjective reflections creates reciprocal opportunity to transform experiential insights into practical strategies for professional growth and practice development.
Comparative Study by Systematic Review and Meta-Analysis of the Peri-Implant Effect of Two Types of Platforms: Platform-Switching versus Conventional Platforms

Objective: The aim of the systematic review and meta-analysis carried out was to evaluate the effects of changing the prosthetic platform on peri-implant tissue after 1 year of prosthetic loading. Material and methods: In November 2020, an electronic search was carried out in PubMed, EMBASE, Web of Science, and Scopus databases with the aim of obtaining all the randomized clinical trials that had been published in the preceding 10 years comparing the effects on the peri-implant tissue of implants with a prosthetic platform change and implants with a conventional platform for at least 1 year after prosthetic loading. Randomized model meta-analyses of the selected studies were performed to compare the results of the two implant groups in terms of vertical maintenance of bone level and increased probing depth. Results: Nine studies were included, summing up a total of 475 implants with prosthetic platform exchange and 462 implants with a conventional platform. Implants with prosthetic platform exchange had less peri-implant bone loss than implants with a conventional platform (mean difference of 0.255 mm, statistically significant) but suffered a greater increase in probing depth (mean difference of 0.082 mm, not statistically significant). However, the probing depth from One Study Remove revealed a statistically significant increase of 0.190 mm in the prosthetic platform exchange group compared to the conventional platform group. Conclusion: Implants with platform switching suffer less peri-implant bone loss after 1 year of loading than implants with a conventional platform. Further long-term studies are required to observe how these differences vary over time.
Validation of a generic impact survey for use by health library services indicates the reliability of the questionnaire

Abstract Background A validated generic impact questionnaire can demonstrate how individual and groups of health libraries contribute to continuing education and patient care outcomes. Objectives To validate an existing generic questionnaire for Knowledge for Healthcare, England by examining: (1) internal reliability; (2) content validity; and (3) suggest revisions. Methods Methods used included Cronbach's alpha test, simple data mining of patterns among a data set of 187 questionnaire responses and checking respondents' interpretation of questions. Results Cronbach's alpha was 0.776 (acceptable internal reliability). The patterns of responses indicated that respondents' interpretations of the questions were highly plausible, and consistent. The meaning of ‘research’ varied among different occupational groups, but overall, respondents could identify relevant personal and service impacts. However, users were confused about the terms that libraries use to describe some services. Discussion The analysis indicated that the questionnaire worked well for the two types of personal services (literature/evidence searches and training/e‐learning) frequently cited on the responses. Further research may be required for library assessment of the impact of other services such as digital resource services. Conclusions The generic questionnaire is a reliable way of assessing the impact of health library and knowledge services, both individually and collectively.