Miracle-dz/UniFAR-FTUs huggingface dataset:
COVID-19 associated coagulopathy and inflammatory response: what do we know already and what are the knowledge gaps?

Patients with COVID-19 frequently experience a coagulopathy associated with a high incidence of thrombotic events leading to poor outcomes. Here, biomarkers of coagulation (such as D-dimer, fibrinogen, platelet count), inflammation (such as interleukin-6) and immunity (such as lymphocyte count) as well as clinical scoring systems (such as SOFA, ISTH DIC and SIC score) can be helpful in predicting clinical course, need for hospital resources (such as ICU beds, intubation and ventilator therapy, and ECMO) and patient's outcome in patients with COVID-19. However, therapeutic options are actually limited to unspecific supportive therapy. Whether viscoelastic testing can provide additional value in predicting clinical course, need for hospital resources and patient's outcome or in guiding anticoagulation in COVID-19 associated coagulopathy is still incompletely understood and currently under investigation (e.g., in the ROHOCO study). This paper summarizes what we know already about COVID-19 associated coagulopathy and - perhaps even more importantly - characterizes important knowledge gaps.
Resveratrol Improves Hepatic Redox Status and Lipid Balance of Neonates with Intrauterine Growth Retardation in a Piglet Model

Abnormal lipid metabolism, oxidative stress (OS), and inflammation play a pivotal role in the increased susceptibility to neonatal fatty liver diseases associated with intrauterine growth retardation (IUGR). This study was firstly conducted to investigate whether resveratrol could alleviate IUGR-induced hepatic lipid accumulation, alteration of redox and immune status in a sucking piglet model and explore the possible mechanisms at transcriptional levels. A total of 36 pairs of 7 d old male normal birth weight (NBW) and IUGR piglets were orally fed with either 80 mg resveratrol/kg body weight/d or 0.5% carboxymethylcellulose sodium for a period of 14 days, respectively. Compared with the NBW piglets, the IUGR piglets displayed compromised growth performance and liver weight, reduced plasma free fatty acid (FFA) level, increased hepatic OS, abnormal hepatic lipid accumulation and weakened hepatic immune function, and hepatic aberrant transcriptional expression of some genes such as heme oxygenase 1, superoxide dismutase 1, sterol regulatory element-binding protein 1c, stearoyl-CoA desaturase 1, liver fatty acid-binding proteins 1, toll-like receptor 4, and tumor necrosis factor alpha (TNF-α). Oral administration of resveratrol to piglets decreased the levels of FFA and total triglycerides (TG) in the plasma and hepatic TNF-α concentration, and increased glutathione reductase activity and reduced glutathione level in the liver. Resveratrol restored the increased alanine aminotransferase activity in the plasma of IUGR piglets. Treatment with resveratrol ameliorated the increased hepatic malondialdehyde, protein carbonyl, TG, and FFA concentrations induced by IUGR. Resveratrol treatment alleviated the reduced lipoprotein lipase activity and its mRNA expression as well as TNF-α gene expression in the liver of IUGR piglets. Hepatic glutathione peroxidase 1 and monocyte chemotactic protein 1 genes expression of piglets was upregulated by oral resveratrol administration. In conclusion, resveratrol administration plays a beneficial role in hepatic redox status and lipid balance of the IUGR piglets.
Gene Expression, Network Analysis, and Drug Discovery of Neurofibromatosis Type 2-Associated Vestibular Schwannomas Based on Bioinformatics Analysis

Neurofibromatosis Type 2- (NF2-) associated vestibular schwannomas (VSs) are histologically benign tumors. This study aimed to determine disease-related genes, pathways, and potential therapeutic drugs associated with NF2-VSs using the bioinformatics method. Microarray data of GSE108524 were downloaded from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) were screened using GEO2R. The functional enrichment and pathway enrichment of DEGs were performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes Genomes (KEGG). Furthermore, the STRING and Cytoscape were used to analyze the protein-protein interaction (PPI) network of all differentially expressed genes and identify hub genes. Finally, the enriched gene sets belonging to the identified pathways were queried against the Drug-Gene Interaction database to find drug candidates for topical use in NF2-associated VSs. A total of 542 DEGs were identified, including 13 upregulated and 329 downregulated genes, which were mainly enriched in terms of focal adhesion, PI3K-Akt signaling pathway, ECM-receptor interaction, Toll-like receptor signaling pathway, Rap1 signaling pathway, and regulation of actin cytoskeleton. 28 hub genes were identified based on the subset of PPI network, and 31 drugs were selected based on the Drug-Gene Interaction database. Drug discovery using bioinformatics methods facilitates the identification of existing or potential therapeutic drugs to improve NF2 treatment.
EVALUATION OF Staphylococcus aureus AND Streptococcus agalactiae ALUMINIUM HYDROXIDE ADJUVANTED MASTITIS VACCINE IN RABBITS

The aim of present study was to prepare and evaluate Staphylococcus aureus and Streptococcus agalactiae aluminium hydroxide adjuvanted mastitis vaccine in rabbits. For this purpose, isolates of these two bacterial species were recovered from aseptically collected milk samples (n=95) of mastitic buffaloes, identified and biocharacterized. Pathogenicity, immunogenicity, and antibiotics sensitivity testing of vaccinal organisms was performed. A bivalent aluminium hydroxide adjuvanted mastitis vaccine was prepared in Mastitis Research Laboratory, Department of Clinical Medicine and Surgery. The vaccine was found stable, sterile and safe to use. Quality of vaccine and its antibody response was evaluated in rabbits. Rabbits were divided into two groups (GA and Gs) of ten rabbits each. Rabbits in group GA were injected with S. aureus and Str. agalactiae aluminium hydroxide adjuvanted mastitis vaccine while rabbits of group Gs served as non-vaccinated control. Vaccine was found stable, sterile and safe to use. Indirect haemagglutination inhibition test was performed for determination of titers against vaccinal S. aureus and Str. agalactiae. Serum antibody titres (GMT) against S . aureus were highest (78.8) at day 45 in the rabbits of group GA which declined slightly to 73.3 on day 60. The gradual increase in IHA titre for Str. agalactiae was also observed at day 45 and day 60 post vaccination. Cumulative mean antibody titre (CMT) was 44.94 for vaccinal S. aureus isolate arid 46.56 for vaccinal Str. agalactiae isolate while in control group (Gs) 2.12 CMT was recorded. The antibody response of vaccine in terms of geometric mean titres was significantly higher in vaccinated group at day 45 and 60 post vaccination as compared to control group.The results of the study indicated that the bivalent(S. aureus and Str. Agalactiae) aluminium hydroxide adjuvanted vaccine was immunogenic in rabbits.
Expression of Membrane Progesterone Receptors in Eutopic and Ectopic Endometrium of Women with Endometriosis

Endometriosis is one of the most frequent gynecological diseases in reproductive age women, but its etiology is not completely understood. Endometriosis is characterized by progesterone resistance, which has been explained in part by a decrease in the expression of the intracellular progesterone receptor in the ectopic endometrium. Progesterone action is also mediated by nongenomic mechanisms via membrane progesterone receptors (mPRs) that belong to the class II members of the progesterone and adipoQ receptor (PAQR) family. The aim of the present study was to evaluate the expression at mRNA and protein levels of mPR members in the eutopic and ectopic endometrium of women with endometriosis. Total RNA and total protein were isolated from control endometrium (17 samples), eutopic endometrium (17 samples), and ectopic endometrium (9 samples). The expression of PAQR7 (mPRα), PAQR8 (mPRβ), and PAQR6 (mPRδ) at mRNA and protein levels was evaluated by RT-qPCR and Western blot, whereas PAQR5 (mPRγ) gene expression was evaluated by RT-qPCR. Statistical analysis between comparable groups was performed using one-way ANOVA followed by Tukey's multiple comparisons test with a confidence interval of 95 %. The analysis of gene expression showed that PAQR7 and PAQR5 expression was lower in both eutopic and ectopic endometrium as compared to the endometrium of women without endometriosis, whereas the expression of PAQR8 and PAQR6 was only reduced in eutopic endometrium. Furthermore, mPRα and mPRβ protein content was decreased in the ectopic endometrium of women with endometriosis. Our results demonstrate a decrease in the expression and protein content of mPRs in eutopic and ectopic endometrium of patients with endometriosis, which could contribute to the progesterone resistance observed in patients with this disease.
Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway

To investigate whether Polyphyllin I (PPI) might induce the autophagy and apoptosis of melanoma cells by regulating PI3K/Akt/mTOR signal pathway. Melanoma A375 cells were incubated with different concentrations of Polyphyllin I (0, 1.5, 3.0, and 6.0 mg/L) and PI3K/Akt/mTOR signaling pathway activator IGF-1(20 mg/L). CCK-8 assay was utilized to detect cell proliferation; Cell apoptosis and cell cycle were measured by flow cytometry; Western blot was used to examine the expressions of proteins. Immunofluorescence analysis was performed to evaluate autophagy of A375 cells; In addition, xenograft-bearing nude mice were applied to study the role of Polyphyllin I on melanoma development, melanoma cell proliferation, as well as melanoma cell apoptosis in vivo. The outcomes represented that Polyphyllin I promoted A375 cell apoptosis via upregulating Bax level and cleaved caspase-3 level and downregulating Bcl-2 level, inhibited the growth of A375 cells at the G0/G1 phase, and enhanced cell autophagy via regulating the levels of Beclin 1, LC3II, and p62. However, IGF-1 (an activator of PI3K/Akt/mTOR signal pathway) attenuated these changes that Polyphyllin I induced. Furthermore, the xenograft model experiment confirmed that Polyphyllin I treatment suppressed xenograft tumor growth, increased apoptotic index evaluated by the TUNEL method, and reduced the level of Ki67 in tumor tissues in vivo. In conclusion, Polyphyllin I treatment enhanced melanoma cell autophagy and apoptosis, as well as blocked melanoma cell cycle via suppressing PI3K/Akt/mTOR signal pathway. Meanwhile, Polyphyllin I treatment suppressed the development of melanoma in vivo. Therefore, Polyphyllin I possibly is a promising molecular targeted agent used in melanoma therapy.
Study on Three Sarcocapnos Species as Potential Sources of Bioactive Compounds: Relation between Phenolic Content and Bioactivity by Multivariate Analysis

In this work, we report the phenolic composition and bioactivity of the aerial parts of three species of Sarcocapnos (S. enneaphylla, S. pulcherrima, and S. saetabensis) to study their potential as sources of bioactive compounds to revalorize them and contribute to the conservation of these plant species. Samples were collected in different locations in the province of Jaén (southeast of Spain), and qualitative and quantitative analyses of phenolic compounds were performed by high-performance liquid chromatography with diode array and mass spectrometry detection. S. enneaphylla presented the highest concentration of phenolic compounds (58 mg/g DE). The most abundant compound in S. enneaphylla and S. saetabensis was rutin (35 mg/g DE and 11.7 mg/g DE, respectively), whereas isorhamnetin-O-rutinoside was dominant in S. pulcherrima (11.5 mg/g DE). Several assays were performed to evaluate the potential bioactivity of the three species of Sarcocapnos. These assays included antioxidant and radical scavenging (ABTS and DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating, and enzyme inhibitory activity (acetylcholinesterase, amylase, butyrylcholinesterase, glucosidase, and tyrosinase). In general, all methanolic extracts presented the highest phenolic and flavonoid contents, as well as the highest radical scavenging, antioxidant, and enzyme inhibitory properties. This relationship between phenolics and bioactivity was confirmed by multivariate analysis.
Surgical abdominal emergencies in disadvantaged area: epidemiologic and therapeutic aspects

Introduction: Surgical abdominal emergencies remain a common topic in surgery, especially in under-equipped environments. Aim: To study the epidemiological, diagnostic and therapeutic aspects of these emergencies at the Savalou-Bantè Zonal hospital in Benin. Patients and methods: This was a prospective study that involved all patients operated for a surgical abdominal emergency at the Savalou-Bantè area hospital from November 1, 2016 to August 31, 2017. Data were analyzed with Epi Info software 3.5. 4 version. Results: Patients operated for an abdominal emergency represented 31.52% of the admissions to the service of emergencies. The sex-ratio was of 1.72. The average consultation time was 5 ± 2.14 days with extremes of 03 hours and 7 days. The abdominal pain was the chief complain with 74.22% admissions. Non-traumatic surgical abdominal emergencies were the most common with 125 cases or 97.66%. Acute appendicitis (58 cases, 45.31%), Acute generalized peritonitis (24 cases, 18.75%) and strangulated hernia (23 cases, 17.97%) were the main etiologies of surgical abdominal emergencies. The diagnosis was clinical in the majority of cases. An imagery examination for diagnostic purposes has been achieved among 34 patients or 26, 56%. The average time for surgical management was 15 hours. The exclusive spinal anesthesia with 85 cases or 66.41% was the more practiced. The approach was laparotomy among all patients. The Antibiotic therapy was probabilistic and systematic. The morbidity was 17.97% (23 cases) dominated by parietal suppurations (15 cases / 23); and mortality of 2.34%. Conclusion: Surgical abdominal emergencies are frequent. Their diagnosis is still mainly clinical and their care is burdened with a non negligible morbidity. Improvement of the technical tray would help to reduce postoperative complications.
High-Resolution Radar Target Recognition via Inception-Based VGG (IVGG) Networks

Aiming at high-resolution radar target recognition, new convolutional neural networks, namely, Inception-based VGG (IVGG) networks, are proposed to classify and recognize different targets in high range resolution profile (HRRP) and synthetic aperture radar (SAR) signals. The IVGG networks have been improved in two aspects. One is to adjust the connection mode of the full connection layer. The other is to introduce the Inception module into the visual geometry group (VGG) network to make the network structure more suik / for radar target recognition. After the Inception module, we also add a point convolutional layer to strengthen the nonlinearity of the network. Compared with the VGG network, IVGG networks are simpler and have fewer parameters. The experiments are compared with GoogLeNet, ResNet18, DenseNet121, and VGG on 4 datasets. The experimental results show that the IVGG networks have better accuracies than the existing convolutional neural networks.
First record of the family Colinauropodidae (Myriapoda, Pauropoda) in China, with the description of three new species

Abstract The pauropod family Colinauropodidae Scheller, 1985 is recorded from China for the first time. Three new species of the genus Colinauropus Remy, 1956 are described: Colinauropus chinensissp. nov. and C. chongzhouisp. nov. from Jiangsu Province, and C. foliosussp. nov. from Sichuan Province. They can be easily separated from similar species by the number and the shape of sclerotized plates on the tergites, setae on the body and the anal plate. A key for all species of the genus is provided.
False-Negative CSF Cryptococcal Antigen with Cryptococcus gattii Meningoencephalitis in Southeastern United States: A Case Report and Literature Review

A 70-year-old immunocompetent male in South Carolina was admitted secondary to altered mental status and headache without focal neurological deficits. Head CT was negative. Lumbar puncture (LP) revealed normal glucose, elevated protein, and lymphocytosis. Opening pressure was 15 cm of H20. CSF lateral flow assay was negative for cryptococcal antigen; CSF cultures showed no growth. The patient rapidly improved on acyclovir and was diagnosed with presumed viral meningitis, as viral PCR and fungal culture were pending at time of discharge. The patient's condition quickly worsened and the patient returned one day later with right arm weakness and dysarthria. Brain MRI revealed T2/flair signal abnormalities in the left frontal lobe with associated parenchymal enhancement. Repeat LP revealed increasing white blood cell count with a worsening lymphocytosis and decreasing glucose, and opening pressure remained normal. CSF fungal culture from the first admission grew Cryptococcus gattii, and repeated CSF cryptococcal antigen and culture returned positive. The patient was started on IV steroids, induction Amphotericin and Fluconazole, followed by maintenance oral Fluconazole. The patient's clinical course was complicated by a brainstem lacunar infarction, which led to demise. We present this case of Cryptococcus gattii meningoencephalitis to highlight the risk factors, characteristics, and challenges in diagnosis and treatment of an emerging disease in the Southeastern United States.
Low Utilization of Partograph and Its Associated Factors among Obstetric Care Providers in Governmental Health Facilities at West Shoa Zone, Central Ethiopia

Background Globally, prolonged and obstructed labors were among the common causes of maternal morbidity and mortality in low- and middle-income countries including Ethiopia. The World Health Organization (WHO) recommends the routine use of partograph as a key intervention to avoid prolonged and obstructed labor. Despite the recommendation, studies indicated that the partograph utilization among obstetric care providers (OCPs) is still low. Therefore, this study is aimed at assessing the level of utilization of partograph and associated factors among obstetric care providers working at health facilities in the West Shoa Zone, Central Ethiopia 2019. Methods Facility-based cross-sectional study was conducted from February 1st to 22nd March 2019. A computer-generated simple random sampling technique was used to select 325 study subjects. Data were collected using a self-administered structured questionnaire and using an observational checklist. Additionally, 200 partograph charts were reviewed. Both bivariate and multivariable logistic regression analyses were used to determine the association. Results A total of 322 obstetric care providers were included in the study, giving a response rate of 99.1%. The level of partograph utilization in the study area was revealed to be 31.1% (95% CI: 25.97-36.13). Only 3% of the reviewed partograph was recorded according to the recommended standard. In this study attending training (AOR = 3.94, 95% CI: 1.99-7.78), availability of partograph (AOR = 5.23, 95% CI: 1.69-16.22), perceived as not time-consuming task (AOR = 3.61, 95% CI: 1.19-10.96), adequate number of OCPs available (AOR = 2.92, 95% CI: 1.16-7.33), presence of supervision (AOR = 4.35, 95% CI: 2.11-8.97), having a positive attitude (AOR = 2.48, 95% CI: 1.23-5.02), availability of standard protocol in a health facility (AOR = 4.71, 95% CI: 2.31-9.60), and lack of commitment (AOR = 0.32, 95% CI: 0.16-0.63) were factors significantly associated with partograph utilization. Conclusion and Recommendation. Partograph utilization in the study area was found to be low. Almost all reviewed partograph charts were not recorded as to the recommended standard. Attending training, availability of partograph, perceived as it is not time-consuming, the available number of OCPs, presence of supervision, having a positive attitude, available standard protocol, and commitment were factors associated with partograph utilization. Therefore, all concerned stakeholders should emphatically consider those identified factors for intervention.
Flora visitada pelas abelhas eussociais (Hymenoptera, Apidae) na Serra da Capivara, em caatinga do Sul do Piauí

This study presents the flora explored by Apis mellifera L. (Africanized honey bee) and stingless bees, and their seasonal phenology, in a caatinga vegetation, located in the Parque Nacional Serra da Capivara, Piaui State, tropical Brazil. During one year, bees were monthly collected with entomological nets, while visiting flowers. Sampling took place in two places. Eusocial bees, A. mellifera and 12 stingless bees species, were collected visiting 69 angiopermas species. Like reported in other studies on caatinga, a plant family heavily foraged was Leguminosae, but there were a few melittophilic species in common. A. mellifera visited 32 floral species and the stingless bees visited 58 species; among them Trigona spinipes Fabr. had the largest spectrum of plant species visited. A. mellifera showed the opportunistic behavior, but this was not observed with the majority of the stingless bee species. Regarding the seasonal phenology, the picture is like others studies conducted in the caatinga: abundance and floral heterogeneity during the rainy station, when the sampling was most effective, and shortage of floral resources during the dry season, when the occurrence of the eusocial bee species was reduced.
Small-scale distribution of fish larvae around the Medes Islands marine protected area (NW Mediterranean)

During the spring and summer of 2003, the small-scale spatial distribution of fish larvae was analysed in and around the Medes Islands marine protected area (MPA). High specific richness was found during both seasons, which is when most coastal fish species spawn in the NW Mediterranean. Despite the small dimensions of the area, well-defined larval fish patterns were found. Larvae from pelagic eggs were located farther from the adult habitat than those from demersal eggs; however, there were exceptions, which highlight the influence of larval behaviour and pelagic larval duration. Inside the reserve, there was both a high diversity index and a high abundance of shorefish larvae in relation to the high abundance of adults and a possible retention of larvae in the MPA. Although there was a great variability both in species composition and abundance between periods, the sampling station assemblages were similar. Factors such as habitat and spawning location of adults, and the role of the MPA seem to determine the stability of the larval distribution patterns in time. The importance of small-scale approaches is highlighted to understand the fish larval spatial distributions.
Adversarial attack on Speech-to-Text Recognition Models

Recent studies have highlighted audio adversarial examples as a ubiquitous threat to state-of-the-art automatic speech recognition systems. Nonetheless, the efficiency and robustness of existing works are not yet satisfactory due to the large search space of audio. In this paper, we introduce the first study of \textit{weighted-sampling audio adversarial examples}, specifically focusing on the factor of the numbers and the positions of distortion to reduce the search space. Meanwhile, we propose a new attack scenario, audio injection attack, which offers some novel insights in the concealment of adversarial attack. Our experimental study shows that we can generate audio adversarial examples with low noise and high robustness at the minute level, compared to other hour-level state-of-the-art methods. \footnote{We encourage you to listen to these audio adversarial examples on this anonymous website.