Miracle-dz/UniFAR-FTUs huggingface dataset:
Network-Based Analysis of Nutraceuticals in Human Hepatocellular Carcinomas Reveals Mechanisms of Chemopreventive Action

Chronic inflammation is associated with the development of human hepatocellular carcinoma (HCC), an essentially incurable cancer. Anti‐inflammatory nutraceuticals have emerged as promising candidates against HCC, yet the mechanisms through which they influence the cell signaling machinery to impose phenotypic changes remain unresolved. Herein we implemented a systems biology approach in HCC cells, based on the integration of cytokine release and phospoproteomic data from high‐throughput xMAP Luminex assays to elucidate the action mode of prominent nutraceuticals in terms of topology alterations of HCC‐specific signaling networks. An optimization algorithm based on SigNetTrainer, an Integer Linear Programming formulation, was applied to construct networks linking signal transduction to cytokine secretion by combining prior knowledge of protein connectivity with proteomic data. Our analysis identified the most probable target phosphoproteins of interrogated compounds and predicted translational control as a new mechanism underlying their anticytokine action. Induced alterations corroborated with inhibition of HCC‐driven angiogenesis and metastasis.
Qualidade do melão exportado pelo porto de Natal-RN

Brazil was studied. The post quality harvest from the melon exported from the Natal-RN port, the qualitative characteristics unfavorable to the market 2,303 fruits were analyzed from September to December of 2002 . Sampling was done according to control norms of Delegacia da Agricultura e do Abastecimento - DFA/SSV. The work was developed in the Natal port, on unit of Vigiagro/SSV/MA. The study in systematic form, using a special form “Card of Quality Control of the Melon Exported” was determined. The contents of solid solubles and pulp firmness. The yellow type were 50.33% from the fruits of the total, 19.06% of the Orange Flesh, 9.90% of the Piel de Sapo , 11.60% of the Galia , 7.03% of the Cantaloupe and 2.52% of the Charentais type. Only the melon Yellow type presented content average of solids soluble accepted for export. The Piel de Sapo melons presented the less firmness of pulp.
Visual deprivation and distance estimation in the praying mantis larva

Abstract. Young larvae of the praying mantis, Tenodera sinensis Saussure, were placed on an off‐centre island surrounded by a round arena with six black bars painted on a white inner wall. In this situation, it was shown that the horizontal peering movements of the head often seen in mantids are in fact used to measure distances; motion parallax may be involved in this process. Aimed jumps that followed peering were taken to be the distinct result of an absolute distance measurement. Specific visual deprivation such as painting over of certain parts of the eye with opaque black varnish or degeneration of the fovea with sulforhodamine showed that: absolute evaluation of distance is only possible with two fully intact eyes; the peering mechanism is under visual control; and visual experience has a long‐term effect on distance measurement involving peering movements.
Checklist of the Benthic Marine Plants of the Madeira Archipelago

Abstract A checklist of the benthic marine plants of the archipelago of Madeira is presented based on published information and personal observations. This list includes 1 Spermatophyte and 359 algal species, comprising 64 Chlorophycota, 64 Chromophycota and 231 Rhodophycota. Fifteen doubtful records for the area are also included.
Comparison of three valuation methods for three tree species at the Arboretum of the Forestry Engineers School (Madrid)

The presented work compares three valuation methods in three tree species of the Arboretum of the Madrid Forestry Engineering School, and is framed in a bigger project of comparison methods of valuation for this Institution. For this study three species with different characteristics were selected and three valuation methods were applied in 43 individuals selected through a species sample. The selected species are some of the most common in Madrid: Ailanthus altissima (Mill.) Swingle, Platanus hybrida Brot. and Cedrus atlantica (Endl) Carrière. The valuation methods employed are: the “American method” of the Council of Tree Landscape Appraisers (CTLA) (CTLA 2000), Norma Granada (NG) (AEPJP 2007) and Capitalization methods (ECM) (Caballer 1999). The sample selection was performed using a species systematic sampling of the individuals, based on the standard deviation of the Diameter at breast hight (Dbh) with an error limit of 5 centimeters and a confidence level of 95%. The comparison of the results has been done with the ttest for paired samples and an ANOVA with species factor and valuation method, with a confidence level of 95%. The results for the standardized variables show no statistically significant differences between methods, and show statistically significant differences between species and also in the interaction of method and species. In the analysis of non-standardized variables, differences between methods, species and the interaction between them were found. The highest valuations were obtained with the NG and ECM methods, and the lowest valuations come from the CTLA method.
Tranexamic Acid Impairs.-Aminobutyric Acid Receptor Type A-mediated Synaptic Transmission in the Murine Amygdala

Background: Tranexamic acid (TXA) is commonly used to reduce blood loss in cardiac surgery and in trauma patients. High-dose application of TXA is associated with an increased risk of postoperative seizures. The neuronal mechanisms underlying this proconvulsant action of TXA are not fully understood. In this study, the authors investigated the effects of TXA on neuronal excitability and synaptic transmission in the basolateral amygdala. Methods: Patch clamp recordings and voltage-sensitive dye imaging were performed in acute murine brain slices. Currents through N-methyl-D-aspartate, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, and γ-aminobutyric acid receptor type A (GABAA) receptors were recorded. GABAA receptor–mediated currents were evoked upon electrical stimulation or upon photolysis of caged GABA. TXA was applied at different concentrations. Results: Voltage-sensitive dye imaging demonstrates that TXA (1 mM) reversibly enhances propagation of neuronal excitation (mean ± SEM, 129 ± 6% of control; n = 5). TXA at concentrations of 0.1, 0.3, 1, 5, or 10 mM led to a dose-dependent reduction of GABAA receptor–mediated currents in patch clamp recordings. There was no difference in the half-maximal inhibitory concentration for electrically (0.76 mM) and photolytically (0.84 mM) evoked currents (n = 5 to 9 for each concentration), and TXA did not affect the paired-pulse ratio of GABAA receptor–mediated currents. TXA did not impact glutamatergic synaptic transmission. Conclusions: This study clearly demonstrates that TXA enhances neuronal excitation by antagonizing inhibitory GABAergic neurotransmission. The results provide evidence that this effect is mediated via postsynaptic mechanisms. Because GABAA receptor antagonists are known to promote epileptiform activity, this effect might explain the proconvulsant action of TXA.
Compliance with occupational health and safety regulations : a review of Nigeria's construction industry

The state of occupational safety and health (OSH) in Nigeria is poor, especially in the construction industry. Compliance with OSH regulations (OSHR) is one of the major factors for OSH improvement; regrettably, its level is low in Nigeria. Although studies on compliance with OSHR in developed countries abound, understanding the issues peculiar to the Nigerian construction industry as per compliance with OSH regulations is pertinent, as contextual issues can make the difference. As a result, this study, which contextualises Nigeria: examines compliance with OSHR in the Nigerian construction industry; unearths the key issues to compliance with OSHR in the industry; demonstrates the state of compliance withOSHR in the industry. Systematic review of available literature gathered through desk literature search and content analysis were done. It unearthed that key issues to compliance with OSHR in the Nigerian construction industry include: client’s influence, inadequate enforcement (which ranks highest), lack of adequate regulations and unemployment, which rank lowest. It concludes that in the absence of government’s involvement and adequate enforcement, stakeholders in the industry and management commitment can help compliance with OSHR proliferate. It also recommends that: OSH professionals should use the economic benefits of compliance with OSH to attract management commitment; contractors’ OSH records should be a prerequisite for tender selection.
Distribution and Quantile Functions, Ranks, and Signs in Rd: a measure transportation approach

Unlike the real line, the real space Rd, for d ≥ 2, is not canonically ordered. As a consequence, such fundamental univariate concepts as quantile and distribution functions, and their empirical counterparts, involving ranks and signs, do not canonically extend to the multivariate context. Palliating that lack of a canonical ordering has been an open problem for more than half a century, generating an abundant literature and motivating, among others, the development of statistical depth and copulabased methods. We show that, unlike the many definitions proposed in the literature, the measure transportation-based ranks introduced in Chernozhukov et al. (2017) enjoy all the properties that make univariate ranks a successful tool for semiparametric inference. Related with those ranks, we propose a new center-outward definition of multivariate distribution and quantile functions, along with their empirical counterparts, for which we establish a Glivenko-Cantelli result. Our approach is based on McCann (1995) and our results, unlike those of Chernozhukov et al. (2017), do not require any moment assumptions. The resulting ranks and signs are shown to be strictly distribution-free and essentially maximal ancillary in the sense of Basu (1959) which, in semiparametric models involving noise with unspecified density, can be interpreted as a finite-sample form of semiparametric efficiency. Although constituting a sufficient summary of the sample, empirical center-outward distribution functions are defined at observed values only. A continuous extension to the entire d-dimensional space, yielding smooth empirical quantile contours and sign curves while preserving the essential monotonicity and Glivenko-Cantelli features, is provided. A numerical study of the resulting empirical quantile contours is conducted. MSC 2010 subject classifications: Primary 62G30; secondary 62B05.
Collective efficacy or team outcome confidence? Development and validation of the Observational Collective Efficacy Scale for Sports (OCESS)

Although collective efficacy has been demonstrated to be an important precursor of team performance, there remains some ambiguity concerning its assessment. Therefore, the main aim of the present study was to test the validity of previous collective efficacy measures. An online survey was completed by 4,451 Flemish players and coaches from nine different team sports. The results revealed two distinct and reliable scales; process-oriented collective efficacy (i.e., the confidence in the team’s skills to accomplish processes that could lead to successes) and outcome-oriented team confidence (i.e., the confidence in the team’s ability to obtain a goal or win a game). Furthermore, we established the validity of a 5-item Observational Collective Efficacy Scale for Sports (OCESS) as short measure of process-oriented collective efficacy. Because the OCESS only includes observable behaviors, this scale has the potential to be a starting point for the development of a continuous in-game measure of collective efficacy.
Newton-Schrödinger Equations are not derivable from General Relativity + Quantum Field Theory

In this note we show that Newton-Schr\"odinger Equations (NSEs) [arXiv:1210.0457 and references therein] do not follow from general relativity (GR) and quantum field theory (QFT) by way of two considerations: 1) Taking the nonrelativistic limit of the semiclassical Einstein equation, the central equation of relativistic semiclassical gravity, a fully covariant theory based on GR+QFT with self-consistent backreaction of quantum matter on the spacetime dynamics; 2) Working out a model [see C. Anastopoulos and B. L. Hu, Class. Quant. Grav. 30, 165007 (2013), arXiv:1305.5231] with a matter scalar field interacting with weak gravity, in procedures analogous to the derivation of the nonrelativistic limit of quantum electrodynamics. We conclude that the coupling of classical gravity with quantum matter can only be via mean fields, there are no $N$-particle NSEs and theories based on Newton-Schr\"odinger equations assume unknown physics.
Regulation Effects of XPJY Decoction on Antioxidative and Mitochondrial Functions in Intracerebral and Extra Brain Tissue of CUMS Rats

Background and objectives The treatment of somatic symptoms of depression is a medical problem nowadays. More and more evidences show that oxidative stress and mitochondrial dysfunction may be an important pathogenesis of depression and are closely related to somatic symptoms. Currently, studies on oxidative stress and mitochondrial function are mostly concentrated in the brain, with less attention paid to peripheral tissues, and classical SSRIs are not direct antioxidants in treatment. XingPiJieYu (XPJY) Decoction is one of the most widely used clinical formulas of traditional Chinese medicine. Our study aims to exploring whether it has antioxidative and mitochondrial effects on intracerebral and extra brain tissue. Materials and Methods The rat model of depression was established by CUMS (chronic unpredictable mild stress, CUMS) for 6 weeks. They were randomly divided into six groups: control group, CUMS group, CUMS+XPJY (3.6g/kg/d, 7.2g/kg/d, 14.4g/kg/d) groups, CUMS+ sertraline (4.5mg/kg/d) group. We used sucrose preference test and forced swimming test to verify the success of the depression model. The contents of CK and SDH in orbital blood were measured weekly as well as the following assay index were measured on 14th day and 42th day, including MDA, ATP and mtDNA in hippocampus, prefrontal cortex, liver, small intestine and gastrocnemius muscle. Results At the 14th day, the sucrose preference ratio was decreased. Besides, the immobility time prolonged at the 42nd day. CUMS increased MDA content in hippocampus, prefrontal cortex and gastrocnemius muscle, but decreased mtDNA content in prefrontal cortex at the 14th day; CUMS decreased serum SDH level at the 35th day, but elevated serum CK level at the 42nd day; CUMS increased MDA content in hippocampus, prefrontal cortex, liver and gastrocnemius muscle, while decreased ATP and mtDNA content in hippocampus, prefrontal cortex, liver, small intestine and gastrocnemius muscle at the 42nd day. XPJY decoction at 14.4g/kg, the efficacy trend of which was better than the other drug groups, could prevent the depressive behavior caused by CUMS, reduce the serum CK content and the MDA content of the tissues mentioned above, and increase serum SDH content as well as ATP, mtDNA content in tissues. Conclusion CUMS could induce oxidative stress and mitochondrial dysfunction in hippocampus, PFC, liver, small intestine and gastrocnemius muscle in rats. Early application of sertraline can effectively prevent mtDNA damage in hippocampus, PFC and liver, but its regulation on MDA and ATP is not obvious. However, XPJY decoction plays an significant role in antioxidation by means of improving mitochondrial function, eliminating inflammation and increasing 5-HT content. This research provides an important theoretical basis for the clinical application of XPJY.
FACULTY PERSPECTIVES OF COMMUNITY SERVICE LEARNING IN TEACHER EDUCATION

Topluma hizmet uygulamalari ile ogrenciler hizmet ederek toplumdaki bir ihtiyaca o toplumun aktif, sorumlu ve demokratik vatandasi olarak cevap verirken ayni zamanda akademik ogrenmelerini de guclendirmektedirler. Bu calismanin amaci, ogretmen egitiminde zorunlu bir ders olarak okutulmaya baslanan Topluma Hizmet Uygulamalari (THU) dersini, bu dersi yuruten ogretim uyelerinin bakis acilari ile degerlendirmektir. Ozellikle ogretim uyelerinin topluma hizmeti nasil acikladiklarini, danismanlar, katilimcilar, topluma hizmet ve deneyimlerinin ozellikleri hakkinda ne dusunduklerini ve dersin degerlendirilmesi konusunda ne tur konu ve sorunlara dikkat cektiklerini arastirmaktir. Veriler, nitel arastirma veri toplama yontemlerinden yari yapilandirilmis gorusme yolu ile toplam 10 ogretim uyesinin katilimindan elde edilmistir. Icerik analizi kullanilmis ve amaclarina, surecine ve dersin programdaki yerine iliskin gorusler olmak uzere uc ayri kategoride siniflandirilarak degerlendirilmistir. Arastirmanin sonuclarina gore danismanlik yapan ogretim uyeleri ogrencilerin problem ve ihtiyaclara karsi duyarlilik, problem cozme becerileri ve proje yapma ve yurutme altyapisini kazanmalarini istediklerini belirtmislerdir. Danismanlar surecin yurutulmesinde danisman yeterliklerinin, uzmanlik alaninin ve kurumlarin seciminin oneminden bahsetmekle birlikte surecin degerlendirilmesinin zorlugu, bir donemlik surenin bu ders icin yetersiz olusu ve gonullulugun esas alinmasi gerektigi gibi konulara dikkat cekmislerdir. Bu alanda sureci ve icerigi degerlendiren daha uzun sureli ve dersin ogrenci uzerindeki kalici etkilerini olcecek calismalara ihtiyac oldugu ayni zamanda hem ogrenci hem danisman ve hem de diger tum paydaslari icine alan kapsamli calismalarinda bu dersin daha iyi degerlendirilmesine ve uygulanmasina katkida bulunacagi oneriler arasindadir
Accounting Anomalies, Risk and Return

ABSTRACT: This paper investigates whether so-called anomalous returns predicted by accounting numbers reflect normal returns for risk or abnormal returns. It does so via a model showing how accounting numbers inform about normal returns if pricing were rational. The model equates expected returns to expectations of earnings and earnings growth, so that any variable that forecasts earnings and earnings growth also indicates the required return if the market prices those outcomes as risky. The empirical results confirm that many accounting anomaly variables (such as accruals, asset growth, and investment) forecast forward earnings and growth, and in the same direction in which they forecast returns. While the lack of an agreed-upon asset pricing model for required returns rules out definitive conclusions, the paper provides both a framework and supporting empirical results indicating that the observed “anomalous” returns associated with accounting numbers are consistent with rational pricing.
Age related changes in clinicopathologic features of oral squamous cell carcinoma (OSCC) in Iranian patients: An epidemiologic study

Introduction : Clinicopathologic characteristics of oral Squamous cell carcinoma (OSCC) affected by age, although it is controversial. In this study the differences in clinicopathological features of OSCC were compared between patients younger and older than 40 years' old. Materials and methods: In this retrospective study the histopathologic records of OSCC patients who underwent surgery in Cancer Institute of Iran during 2005-2015 were retrieved. The demographic and histopathologic features of patients in two groups of younger than 40 and older than 40 years old were recorded and descriptive analysis was used for statistical interpretation between groups. Results: The most cases of OSCC in both groups was registered in males with 14.3% and 85.7% of cases in younger and older than 40, retrospectively. Tongue was the most prevalent anatomic location of OSCC in both groups (39%). Based on clinicopathologic features, most prevalent pathologic degree of OSCC in younger aged patients was moderately differentiated OSCC (14.5%). In patients older than 40, well differentiated OSCC (87.7%) was more prevalent. Conclusion: Based on histopathologic features, the moderately differentiated and well differentiated OSCC were more in younger and older patients than 40, respectively. The finding suggests that OSCC has more malignant feature in young patients.
Resistin-Like Molecule β (RELMβ/FIZZ2) Is Highly Expressed in the Ileum of SAMP1/YitFc Mice and Is Associated with Initiation of Ileitis1

SAMP1/Fc mice develop spontaneous ileitis that shares many features with human Crohn’s disease. One of the earliest features of ileitis in SAMP1/Fc mice is an increase in the number of ileal goblet and intermediate cells. Resistin-like molecule β (RELMβ) is a goblet cell-specific, cysteine-rich peptide previously shown to function as part of the innate immune response. In this study, we examined the role of expression of RELMβ in the initiation of ileal inflammation in SAMP1/Fc mice. RELMβ was highly induced in the ilea of SAMP1/Fc mice beginning at age 5 wk, coincident with the histological appearance of inflammation. RELMβ was found in ileal goblet cells and some intermediate and Paneth cells. Surprisingly, RELMβ mRNA levels were significantly increased in the ilea of 80% of germ-free SAMP1/Fc mice examined compared with specific pathogen-free AKR control mice of similar age. Ileitis was observed in germfree SAMP1/Fc mice, although it was attenuated relative to specific pathogen-free SAMP1/Fc mice. These data suggest that neither the early induction of RELMβ expression nor ileal inflammation requires the presence of viable intestinal flora. Neither was the induction of RELMβ dependent on the major Th1 or Th2 cytokines. However, RELMβ stimulated naive bone marrow-derived macrophages to secrete significant amounts of TNF-α, IL-6, and RANTES. Our data suggest that RELMβ is involved in the initiation of ileitis in SAMP1/Fc mice and may act through the induction of proinflammatory cytokines from resident immune cells within the mucosa.
Decay resistance of five Indonesian bamboo species against fungi.

SUPRAPn S. 2010. Decay resistance of five Indonesian bamboo species against fungi. The decay resistance of five bamboo species, i.e. ampel bamboo (Bambusa vulgaris), betung bamboo (Dendrocalamus asper), andong bamboo ( Gigantochloa pseudoarundinacea), tali bamboo ( G. apus) and wulung bamboo ( G. atroviolacea), collected from Bogor and Yogyakarta, was evaluated using the Kolle flask method (dried blocks on malt agar in flasks). The bamboo samples were divided longitudinally into three parts, namely, bottom, middle and top portions. Bambusa vulgaris, G. apus and G. atroviolacea were found to be moderately resistant to attack by 15 fungi, whereas G. pseudoarundinacea and D. asper were not resistant. Weight losses between bottom, middle and top portions of bamboo were not significantly different. However, the highest weight loss was encountered on the middle portion of G. pseudoarundinacea exposed to Pycnoporus sanguineus HHBI-324 (38.3%), while the lowest was found on the bottom portion of B. vulgaris exposed to Lentinus lepideus (2.3%). The most severe decay was caused by P. sanguineus HHBI-324, Tyromyces palustris and Polyporus sp.