Miracle-dz/UniFAR-FTUs huggingface dataset:
Pyridyl Methylsulfinyl Benzimidazole Derivatives as Promising Agents against Giardia lamblia and Trichomonas vaginalis

Protozoan parasites, such as Giardia lamblia and Trichomonas vaginalis, cause the most prevalent infections in humans in developing countries and provoke significant morbidity and mortality in endemic countries. Despite its side-effects, metronidazole is still the drug of choice as a giardiacidal and trichomonacidal tissue-active agent. However, the emergence of metronidazole resistance and its evolved strategies of parasites to evade innate host defenses have hindered the identification and development of new therapeutic strategies against these parasites. Here, we tested five synthesized benzimidazole derivatives as possible drugs for treating giardiasis and trichomoniasis, probing the bifunctional enzyme glucose 6-phosphate dehydrogenase::6-phosphogluconolactone from G. lamblia (GlG6PD::6PGL) and T. vaginalis (TvG6PD::6PGL) as a drug target. The investigated benzimidazole derivatives were H-B2M1, H-B2M2, H2N-BZM6, O2N-BZM7, and O2N-BZM9. The recombinant enzymes were used in inhibition assays, and in silico computational predictions and spectroscopic studies were applied to follow the structural alteration of the enzymes and identify the possible mechanism of inhibition. We identified two potent benzimidazole compounds (O2N-BZM7 and O2N-BZM9), which are capable of inhibiting both protozoan G6PD::6PGL enzymes and in vitro assays with these parasites, showing that these compounds also affect their viability. These results demonstrate that other therapeutic targets of the compounds are the enzymes GlG6PD::6PGL and TvG6PD::6PGL, which contribute to their antiparasitic effect and their possible use in antigiardial and trichomonacidal therapies.
A local property of absolutely convergent Jacobi polynomial series

^We then form the normalized polynomials R{na>β)(x) = P^β){x)IP^β\l), so that sup. ^^i \R{f>β)(x)\ = 1, Vw ^ 0. We let AJ(α, /9, 0) denote the space of series f(x) = Σ»=o αJ^'^OiO subject to the condition Σ*=o|αJ < °° The main result of Chapter 2 of this paper states that if /e AJ(α, βf 0) and if 0 < e < τr/2 then on [e, π — e] we can write
Do positive income shocks benefit children’s education? Evidence from Vietnam

ABSTRACT This study investigates the causal effect of positive income shocks on education in Vietnam using the 1993 and 1998 Vietnam Living Standard Surveys. We measure income shocks by families’ lottery winnings, controlling for lottery purchases. In general, lottery winnings have no significant effect on school enrolment. However, we find a positive and significant effect from lottery winnings on expenditure for children’s education. A 1% increase in lottery winnings increases expenditure on children’s education by 0.12%. Interestingly, we find a stronger effect from lottery winnings on school enrolment and expenditure for education for girls than for boys, helping to decrease gender inequality in education.
Metagenomics and metatranscriptomics reveal broadly distributed, active, novel methanotrophs in the Gulf of Mexico hypoxic zone and in the marine water column

Abstract The northern Gulf of Mexico (nGOM) hypoxic zone is a shallow water environment where methane, a potent greenhouse gas, fluxes from sediments to bottom water and remains trapped due to summertime stratification. When the water column is destratified, an active planktonic methanotrophic community could mitigate the efflux of methane, which accumulates to high concentrations, to the atmosphere. To investigate the possibility of such a biofilter in the nGOM hypoxic zone we performed metagenome assembly, and metagenomic and metatranscriptomic read mapping. Methane monooxygenase (pmoA) was an abundant transcript, yet few canonical methanotrophs have been reported in this environment, suggesting a role for non-canonical methanotrophs. To determine the identity of these methanotrophs, we reconstructed six novel metagenome-assembled genomes (MAGs) in the Planctomycetota, Verrucomicrobiota and one putative Latescibacterota, each with at least one pmoA gene copy. Based on ribosomal protein phylogeny, closely related microbes (mostly from Tara Oceans) and isolate genomes were selected and co-analyzed with the nGOM MAGs. Gene annotation and read mapping suggested that there is a large, diverse and unrecognized community of active aerobic methanotrophs in the nGOM hypoxic zone and in the global ocean that could mitigate methane flux to the atmosphere.
Influence of harmonic and pulse excitations on response of foundations

ABSTRACT This investigation reports analysis of foundations to study its time-displacement response with due consideration to hardening and softening behaviour under combined harmonic and pulse loadings. Based on time of application of pulse loading to foundation and the occurrence of maximum deflection, two cases of analysis are considered and solutions are obtained for underdamped system using semi-analytical approach. The influence of combined action of two different loading is studied. Detailed parametric study is carried out to understand the influence of parameters such as mass of machine-foundation system, ratio of plastic to elastic stiffnesses, damping, frequency ratio and, resistance of soil on time-displacement history of system. Maximum displacement of the system increases to the extent of 48% with 22% increase in initial pulse load magnitude. Damping, mass and stiffness of SDOF system affected the response significantly. Results showed interaction due to combined action of harmonic and pulse loading should not be neglected.
ISO observations of symbiotic stars. I. HM Sge

We present ISO SWS and LWS observations of the symbiotic star HM Sge. The infrared emission longward of 5m is dominated by a silicate dust shell. There is a number of high ionization emission lines superimposed on the dust continuum. The ISO continuum spectra can be tted with a single, optically thick silicate dust shell but such a model does not t other known properties of this system, such as the observed JHK colours, the optical visibility of the red giant and the occurrence of a dust obscuration event. We favour a two component model in which in addition to a partial Mira dust shell, a second dust component is associated with the hot source. This second shell is located at the interface between the Mira dust shell and the dust free region carved out by the hot component. This picture corresponds closely to that deduced independently from radio observations. The two dust components are very dierent. The dust envelope associated with the Mira is very extended and optically thin, whereas the second dust component is geometrically rather thin but dust rich. The model not only ts the ISO data reasonably well, but is also compatible with other IR properties of HM Sge. The thin dust shell contributes strongly to the dust emission over most of the ISO range. It may be the combination of the two shells that makes a symbiotic a D type. The general agreement of the present models with ISO observations indicate that radiation (rather than collisions) as the main dust heating mechanism is sucient.
THE EFFECTIVENESS OF LAW NUMBER 6 OF 2014 CONCERNING VILLAGE IN RELATIONSHIP WITH COMMUNITY PARTICIPATION

This study aims to determine how the application and the extent to which the factors that influence Law Number 6 of 2014 concerning Villages are related to the participation of the people of Bojo Village, Budong-budong District, Central Mamuju Regency. The research method used is "Field Research and Study literature”, the sources were obtained from interviews and various literatures related to the effectiveness of Law Number 6 of 2014 concerning Villages qualitatively and presented descriptively. The results of this study are as follows (1) In the application of Law Number 6 of 2014 concerning Villages it can be said that it is not effective in the community of Bojo Village, Budong-budong District, Central Mamuju Regency. During the enactment of the Village Law, there were still many residents who did not know the existence and contents of the Village Law, and there was still very little community participation in various activities carried out in Bojo Village. (2) In its implementation, the Village Law Number 6 of 2016 has several factors that affect the effectiveness of its enforcement, one of which is that the condition of the community is mostly farmers and plantation workers causing frequent Village activities that are not followed by the community on the grounds that they are more concerned with doing work in order to fulfill their needs. necessities of life
EVOLVING MODEL OF SCALE-FREE NETWORKS WITH INTRINSIC LINKS

In this paper, we introduce the concept of intrinsic link, which is used to describe the intrinsic interactions between the individuals in complex systems. Furthermore, we present a model for the evolution of complex networks, in which the system dynamics motivated by four mechanisms: the addition of new nodes with preferential attachment, the addition of new nodes with intrinsic attachment, the addition of new links with preferential attachment and the addition of new intrinsic links. The model yields scale-free behavior for the degree distributions as confirmed in many real networks. With continumm theory, we get the analytical expressions of the degree distribution and the scaling exponent γ. The analytical expressions are in good agreement with the numerical simulation results.
Electron impact double ionisation of Ar+ and Ar4+ ions

Employing an improved crossed-beam technique described in the preceding paper, cross sections sigma q,q+2 for electron impact double ionisation of Arq+ ions (q=1 and q=4) were measured for electron energies from threshold to about 700 eV. The improved experimental accuracy allowed contributions of L-shell ionisation-autoionisation to sigma 1,3 to be identified for Ar+. With increasing q the relative importance of the L-shell contribution to sigma q,q+2 strongly increases. As a result the cross section sigma 4,6 for Ar4+ is by far dominated by the L-shell contribution at energies above 350 eV. Calculations on the basis of semiempirical and semiclassical theories are made to compare the relative strengths of direct double ionisation and inner-shell ionisation with subsequent electron emission.
Hepatorenal protective activity of Artemisia against diclofenac toxicity in male rats

Introduction Artemisia is one of the important alternative treatments for many diseases, as well as the prevention of the effect of oxidizing substances that cause damage to the various organs of the body, including the liver and kidneys. The kidney and the liver are considered the body's most critical organs, and their functions in storage, metabolism, detoxification and elimination of medications, and their metabolic products make them target structures for “drug-induced” harm. The goal of this investigation was to see if Artemisia extract might protect hepatic and renal tissues from diclofenac-induced damage. Methods a total of 40 adult Wistar rats were separated equally into four groups randomly. The rats of the control group got only distilled water orally without medicine or therapy, while those in the second group administrated 100mg/kg/day of Artemisia orally for one month. The third group received 10mg/kg/day of Diclofenac (DF) orally. The fourth group received 10mg/kg/day of DF and 100mg/kg day of Artemisia orally. After one month, kidney parameters (albumin, creatinine, and urea) and liver parameters (aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)) were measured. Results the results revealed increasing in the kidney (albumin, creatinine, and urea) parameters and liver parameters (AST, ALT, and ALP) in the group treated with diclofenac compared to the control group while they decreased significantly (p≤0.05) in diclofenac + Artemisia group comparing to diclofenac group. Conclusion we conclude from these results that Artemisia may have a role in reducing the toxic effect of diclofenac on kidney and liver by decreasing the liver enzymes and kidney criteria in the blood. The aim of the present study is to evaluate the role of Artemisia to reduce the toxic effect of diclofenac on liver and kidney.
Child Eveningness as a Predictor of Parental Sleep

Child eveningness has been associated with many adverse outcomes for children. The aim of this study was to assess whether child eveningness poses a risk to parental sleep quality in follow-up. A total of 146 children (57% adopted, 47% boys, mean age at follow-up 5.1 years [standard deviation 1.7]) completed a 1-week actigraph recording to analyze their sleep twice, 1 year apart. The parents completed the Child ChronoType Questionnaire for their child and a short version of the Morningness–Eveningness Questionnaire for themselves and the Jenkins Sleep Scale for their sleep quality. Linear regression analyses showed that subjective parental sleeping problems at baseline were associated with subjective parental sleeping problems at follow-up. A morning-type child decreased the risk of parental sleeping problems at the 1-year follow-up compared to the child evening chronotype. Additionally, the child intermediate chronotype decreased the risk of maternal sleeping problems at the 1-year follow-up compared to the evening chronotype of the child. Parents of evening-type children experienced more sleeping problems in the follow-up, compared to parents of morning-type children. This finding encourages parents and professionals to steer the diurnal rhythm of evening-type children toward an earlier daily routine.
The “Worst-Case Scenario”: Recovery Between Repeated High-Intensity Efforts in Rugby League Match-Play

Background: Repeated high-intensity effort (RHIE) activity is known to be a critical component of high-intensity, intermittent team sports. Despite the importance of this quality, there are few studies comparing the RHIE activity of higher- and lower-ranked teams competing in the same competition. This study characterized the distribution of recovery times between RHIE in Top 4 and Bottom 4 semi-elite rugby league players. Hypothesis: Players from Top 4 teams will engage in a greater frequency of RHIE bouts than Bottom 4 teams, with shorter recovery periods between consecutive efforts. Study Design: Cohort study. Methods: A total of 104 semi-elite rugby league players from 11 teams wore global positioning system units during 28 Queensland Cup rugby league matches. Recovery between efforts was classified as <10, 11 to 20, 21 to 30, 31 to 60, and 61 to 120 seconds. Results: The majority of RHIE bouts were performed with ≤10 seconds recovery between efforts for both Top 4 and Bottom 4 teams. Top 4 teams performed a greater proportion of RHIE bouts with ≤10 seconds recovery between efforts than Bottom 4 teams (effect size [ES], 0.27 ± 0.19), while only trivial differences (ES, 0.17 ± 0.20) were found between Top 4 and Bottom 4 teams for the proportion of RHIE with 61 to 120 seconds recovery between efforts. Wide-running forwards from Top 4 teams performed a greater proportion of RHIE bouts with ≤10 seconds recovery between efforts (ES, 0.59 ± 0.40) and a smaller proportion of RHIE bouts with 61 to 120 seconds recovery between efforts (ES, 0.62 ± 0.38) than wide-running forwards from Bottom 4 teams. Conclusion: Rugby league players perform proportionally more RHIE bouts with ≤10 seconds recovery between efforts than any other recovery duration. In addition, Top 4 teams are more likely to complete a greater proportion of short (≤10 seconds) recovery RHIE bouts than Bottom 4 teams. Clinical Relevance: These findings demonstrate the demanding nature of RHIE activity in rugby league. To be successful, teams should train for these demanding passages of play.
Spark plasma sintering of pure and doped tungsten as plasma facing material

In the current water cooled divertor concept, tungsten is an armour material and CuCrZr is a structural material. In this work, a fabrication route via a powder metallurgy process such as spark plasma sintering is proposed to fully control the microstructure of W and W composites. The effect of chemical composition (additives) and the powder grain size was investigated. To reduce the sintering temperature, W powders doped with a nano-oxide dispersion of Y2O3 are used. Consequently, the sintering temperature for W-oxide dispersed strengthened (1800 °C) is lower than for pure W powder. Edge localized mode tests were performed on pure W and compared to other preparation techniques and showed promising results.
Identifying the Structure and Propagation of Dawnside Pc5 ULF Waves Using Space‐Ground Conjunctions

Pc5 ultralow frequency waves are important for transferring energy between the magnetosphere and ionosphere. While many observations have been performed on Pc5 waves properties, it has been difficult to determine the source region, signal propagation path, and the two‐dimensional structure of Pc5 waves beyond coverage by a small number of satellites. Pc5 waves often show a dawn‐dusk asymmetry, but the cause of the asymmetry is under debate. To address these issues, we used conjunction events between the THEMIS satellites and all‐sky imagers and analyzed two Pc5 wave events that were stronger on the dawnside. For both events, the Pc5 waves propagated from dawnside magnetopause toward the nightside magnetosphere. The Pc5 waves were also associated with dawnside magnetopause surface waves, which were probably induced by the Kelvin‐Helmholtz instability. The ionospheric equivalent currents identified multiple vortices on the dawnside associated with quasi‐periodic auroral arcs and much weaker perturbations on the duskside. Global auroral imaging also presented a similar dawn‐dusk asymmetry with multiple arcs on the dawnside, while only one or two major arcs existed on the duskside. Pc5 waves in the magnetosphere had an anti‐phase relation between the total magnetic field and thermal pressure, with a slower propagation velocity compared with magnetohydrodynamic waves. The Poynting flux was anti‐sunward with an oscillating field‐aligned component. These properties suggest that Pc5 waves were slow or drift mirror mode waves coupled with standing Alfven waves. The ground‐based and multi‐satellite observations provide crucial information for determining the Pc5 waves properties, possible source region, and signal propagation path.
Potential for photoacoustic imaging of the neonatal brain

Photoacoustic imaging (PAI) has been proposed as a non-invasive technique for imaging neonatal brain injury. Since PAI combines many of the merits of both optical and ultrasound imaging, images with high contrast, high resolution, and a greater penetration depth can be obtained when compared to more traditional optical methods. However, due to the strong attenuation and reflection of photoacoustic pressure waves at the skull bone, PAI of the brain is much more challenging than traditional methods (e.g. near infrared spectroscopy) for optical interrogation of the neonatal brain. To evaluate the potential limits the skull places on 3D PAI of the neonatal brain, we constructed a neonatal skull phantom (1.4-mm thick) with a mixture of epoxy and titanium dioxide powder that provided acoustic insertion loss (1-5MHz) similar to human infant skull bone. The phantom was molded into a realistic infant skull shape by means of a CNCmachined mold that was based upon a 3D CAD model. To evaluate the effect of the skull bone on PAI, a photoacoustic point source was raster scanned within the phantom brain cavity to capture the imaging operator of the 3D PAI system (128 ultrasound transducers in a hemispherical arrangement) with and without the intervening skull phantom. The resultant imaging operators were compared to determine the effect of the skull layer on the PA signals in terms of amplitude loss and time delay.
Does employee management influence the continued use of telework after the COVID-19 pandemic?

This paper analyses the intention of Spanish companies to continue using telework after the end of the COVID-19 pandemic. With this aim, we consider the influence that the management of several variables related to one of the key stakeholders, employees, has on this intention. This line of study is of great interest, given the implications not only for the management of companies, but also for key aspects such as the goals of the 2030 Agenda for Sustainable Development. To this end, we start with a review of the relevant literature on this topic, which allows us to raise various research hypotheses. This is followed by an analysis of a sample of 1,879 Spanish SMEs though a binary logistic regression model, which shows the positive influence of managers’ university education and companies’ orientation towards innovation on the use of telework after the pandemic.
Observational Undersampling in Tropical Cyclones and Implications for Estimated Intensity

AbstractThe maximum surface wind speed is an important parameter for tropical cyclone operational analysis and forecasting, since it defines the intensity of a cyclone. Operational forecast centers typically refer the wind speed to a maximum 1- or 10-min averaged value. Aircraft reconnaissance provides measurements of surface winds; however, because of the large variation of winds in the eyewall, it remains unclear to what extent observing the maximum wind is limited by the sampling pattern. Estimating storm intensity as simply the maximum of the observed winds is generally assumed by forecasters to underestimate the true storm intensity. The work presented herein attempts to quantify this difference by applying a methodology borrowed from the observing system simulation experiment concept, in which simulated “observations” are drawn from a numerical model. These “observations” may then be compared to the actual peak wind speed of the simulation. By sampling a high-resolution numerical simulation of Hurri.
Curves for ground wave propagation over mixed land and sea paths

Specific numerical results are presented for ground wave propagation over paths which are part sea and part land. The problem is idealized to the extent that the earth is a smooth spherical surface. The method is based on a previous formulation in terms of mutual impedance between two vertical electric dipoles on an inhomogeneous spherical earth. Amplitude and phase of the ground wave are given for various combinations of the following parameters: frequency 1000, 100, and 20 kc; land conductivities 100 and 10 mmhos/meter; and a sea conductivity of 4 mhos/meter. Most of the curves exhibit the well-known recovery effect which occurs beyond the coast line for propagation from land towards the sea.