Miracle-dz/UniFAR-FTUs huggingface dataset:
The Holocene dynamics of moss communities in subalpine wetland ecosystems in the Eastern Carpathian Mountains, Central Europe

Abstract. In this paper, we present high-resolution, contiguous plant macrofossil records taken from two glacial cirque mountain wetland ecosystems located in the subalpine zone of the Eastern Carpathians. We provide 1) a detailed reconstruction of plant succession from mountain peatland ecosystems; 2) a possible scenario of Holocene paleohydrological changes; 3) the presence of rare plants presently considered glacial relicts, e.g. Meesia triquetra; and 4) the peat forming potential of certain plants at altitudes above 1800 m a.s. l. At Gărgălău, a gradual decrease of water level and isolation from ground water influence approximately 7000 cal yr BP trigged the colonization of minerotrophic Sphagnum species (S. teres, S. centrale and S. subsecundum). The decline of Sphagnum subsecundum ca. 3000 cal yr BP was most likely caused by an increase of water level and competiton with Sarmentypnum sarmentosum populations. In the Late Holocene, ca. 2000 cal yr BP, Selaginella selaginoides expansion was recorded, followed by the reappearance of Sphagnum populations, most likely due to a lowering of the water table. The Gropile ecosystem transformed from a shallow lake into peatland at ca. 4200 cal yr BP. The temporary presence of Warnstorfia exannulata in peat sediments ca. 2300, 1600, 1300–1200, and 700–600 cal yr BP may indicate an increase of water level and very wet habitat, or the presence of small ponds. Paleohydrological changes only partly agree at both studied wetlands, suggesting the importance of local climatic and morphological conditions on past vegetation development. According to our paleoecological data, Straminergon stramineum indicates wet stages in peatlands and cannot be considered a high peat-forming species in subalpine zones in European mountain ranges. Projected warm and dry conditions may trigger mountain peatland water tables in Eastern Carpathians to decline, potentially resulting in the expansion of moss species that demand more acidic and drier habitats, e.g. Sphagnum russowii.
Blood pressure measurements during intraoperative pediatric scoliosis surgery

Background: Intraoperative hypotension is frequently encountered during surgery and it can be associated with adverse outcomes. Blood pressure monitoring is critical during surgery, but there are no universally agreed upon standards for interpreting values of hypotension and no consensus regarding interventions. Material and Methods: We performed a retrospective chart review of pediatric patients who underwent idiopathic scoliosis surgery by a single surgeon. We used the arterial line for all measures. Intraoperative hypotension was defined as 20% decrease of the baseline systolic blood pressure (SBP), 30% decrease of baseline SBP, or mean arterial pressure less than 60 mmHg. Use of vasopressor agents was also recorded and correlated with blood pressure definitions. Results: Seventy idiopathic scoliosis patients were retrospectively evaluated. There was a significant correlation between the three measures of hypotension. Sixty percent of the patients received vasopressors. There was a significant correlation between a drop of mean arterial pressure to less than 60 mmHg and the use of the ephedrine. We did not find any changes on neuromonitoring measures during the case and there were no intraoperative or one-month postoperative complications. Conclusions: Blood pressure is only one of the measures anesthesiologists look to for good perfusion during surgery. Pediatric anesthesiologists and orthopedics agree in trying tight blood pressure control during surgery to decrease blood loss, but what the exact definition of that blood pressure number is, is still unclear. We propose that using mean arterial pressure less than 60 mmHg is perhaps a better definition. We provide recommendations for future studies.
Mexican Basic Psychological Need Satisfaction and Frustration Scale in Physical Education

Basic psychological needs are an energizing state that, if satisfied, will produce an increase in confidence and a healthy motivational orientation that leads to wellness. Frustration of these needs is the opposite concept of satisfaction, which refers to the negative sensation experimented by an individual when he or she perceives that their psychological needs are being actively limited by the actions of the significant other. To date, we have not found instruments validated in Spanish that measure both the satisfaction and the frustration of basic psychological needs in the physical education (PE) context. Therefore, the aims of this study are adapting the Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS) to the PE context in Mexico; and examine its psychometric properties, structure, and factorial invariance by gender in a sample of fifth- and sixth-grade elementary school students. This study included a total of 1,470 fifth- and sixth-grade students from elementary schools in the metropolitan area of Monterrey, Nuevo Leon, Mexico. The results support the reliability, validity, structure, and strict invariance of the sixth Mexican version of the BPNSFS in physical education (BPNSFS-PE). The BPNSFS-PE can be used to measure the satisfaction and/or frustration of the basic psychological needs of students in PE class and to perform comparisons between groups of boys and girls.
A Grid Based Joint Localization and Packet Routing Algorithm in Wireless Sensor Networks

Localization plays a key role in the field of wireless sensor networks (WSNs) that provide services for data collection. The localization accuracy often depends on the accuracy of distance estimation because of the constraints in size, power, cost and memory of sensor nodes. This paper proposes a novel grid based joint localization and packet routing algorithm in WSN based on beacon nodes to improve the precision in location estimation. Firstly, system model of Grid based WSN node localization is constructed. Then localization algorithm of WSN is proposed by using Hybrid Algorithm called Particle Swarm Optimization and Type-2 Fuzzy Logic Filter. Next, form dynamic clusters using node energy. In third step, perform packet routing using Enriched Ant Colony Optimization Algorithm (E-ACO). A shortest and reliable path identified based on node residual energy, degree and distance between nodes. Finally, malicious node detected during data transmission using RSA Digital Signature Algorithm. The simulation of the proposed scheme is performed using NS3.26. The results show that the performance of the proposed scheme is better than the traditional localization algorithms in terms of localization accuracy, localization error, energy consumption, and computation time.
Repurposing Clinical Drugs as AdoMetDC Inhibitors Using the SCAR Strategy

With the escalating costs in drug development, discovering new uses of approved drugs, i.e., drug repurposing, has attracted increasing interest. Spermidine and spermine are important polyamines for most cells and their biosynthesis are strictly regulated by the polyamine metabolic network. In cancerous cells and tumor environments, the concentrations of polyamines are much higher than in normal cells. During the synthesis of spermidine and spermine, an amino-propyl group is provided by decarboxylated S-adenosylmethionine, and the latter is generated from S-adenosylmethionine by AdoMetDC (AdoMet decarboxylase). Therefore, as a rate-limiting enzyme in the biosynthesis of spermidine and spermine, AdoMetDC has been an attractive drug target in cancer studies. In the last decades, many AdoMetDC inhibitors have been discovered, and several AdoMetDC inhibitors are under clinical trials, but unfortunately, none of them have been approved yet. To overcome the high costs in time and money for discovering de novo inhibitors, we set out to repurpose clinic drugs as AdoMetDC inhibitors. We used steric-clashes alleviating receptors (SCAR), a computer-aided drug discovery strategy developed by us recently for in silico screening. By combining computational screening and experimental validation, we successfully identified two approved drugs that have inhibitory potency on AdoMetDC’s enzymatic activity. SCAR was previously shown to be suitable for the discovery of both covalent and non-covalent inhibitors, and this work further demonstrated the value of the SCAR strategy in drug repurposing.
60 GHz Waveguide-Fed Cavity Array Antenna by Multistepped Slot Aperture

This letter presents a center-feed high-gain and high-efficiency 4 × 4-element slot array antenna in the 60 GHz band. The antenna feed network is designed using only a single-layered square quad-ridge cavity structure, which is excited through a rectangular slot that has the same size as that of a standard WR-15 rectangular waveguide. The proposed antenna avoids any conventional power dividers in the feed network, which reduces the complexity of the design and fabrication process. To enhance the operating bandwidth of the antenna and prevent the grating lobes effects, a stepped design is used for each radiating slots of the array. Furthermore, the overall radiating aperture of the antenna is equipped with a dielectric layer, which decreases the mutual coupling among array elements. As a result, a broad bandwidth antenna with high efficiency and low sidelobes in both E- and H-planes is developed over the 60 GHz band. The antenna has been fabricated and tested. Measurement results show an operating bandwidth of 11.6% from 57.7 to 64.7 GHz. A gain of more than 23 dBi, sidelobes of less than −15.2 dB, and an antenna efficiency of better than 60% are achieved.
Positive Influence of Stroke Health Manager on Risk Factors Control and Medication Adherence After Ischemic Stroke

Background: From 2017, the Stroke Health Manager Training Project was carried out by the Chinese Government to strengthen health management and follow-up intervention after ischemic stroke. The aim of this study was to investigate whether after the intervention of the stroke health manager, the control of blood pressure, low-density lipoprotein cholesterol (LDL-C), glucose level, and the use of secondary prevention medications improved 3 months after discharge from our center following ischemic stroke. Methods: The study used a history-controlled approach. Patients who received stroke health manager intervention from May 1, 2018, to March 31, 2019, were considered as the intervention group; those from May 1, 2017, to April 30, 2018, were enrolled as the control group. Stroke health manager intervention included health education, discharge advice, online WeChat public group follow-up, and clinical consultation. Results: In total, 642 patients with ischemic stroke were enrolled in this study (277 in the control group, 365 in the intervention group). At 3 months, the blood pressure, LDL-C and glucose control in the intervention group were better than in the control group (all P < 0.05). At the same time, the overall persistence for secondary prevention medications at 3 months after discharge increased from 201/277 (72.56%) to 303/365 (83.01%, P = 0.001). The persistence for patients taking antiplatelet, hypoglycemic and statins were significantly higher in the intervention group (P < 0.05). Conclusions: Stroke health manager intervention improved the control of blood pressure, LDL-C, glucose levels and the persistence for secondary prevention medications 3 months after discharge.
Rectification Improvement With Flat-Topped Beams on 2.45-GHz Rectenna Arrays

This article proposes the application of microwave power transfer (MPT) with the drone. As a feasibility study, MPT experiments were conducted to a receiver 1.2 away from a transmitter at 2.45 GHz. We aimed to enhance the rectification efficiency of the MPT by array antenna beamformings, named flat-topped beams. We conducted power transfer experiments between the transmitting antenna and the receiving antenna, where a port-to-port efficiency of 31.4% was confirmed on the flat-topped beams. Using the measured illuminance distributions of flat-topped beams on a rectenna plane, we provided a detailed comparison of the rectification efficiencies between conventional uniform beams and the designed flat-topped beams. The obtained rectification efficiency of the series/parallel rectenna array was 68.5%/65.4% in the flat-topped beams and 60.8%/61.1% in the uniform beams. The results of the experiments revealed that the flat-topped beams almost exhibited no connection loss of the rectenna array. Based on the above results, there is a possibility to achieve a high overall efficiency of approximately 60% with the flat-topped beam MPT.
Morphological and Molecular Diversity of Benthic Cyanobacteria Communities Versus Environmental Conditions in Shallow, High Mountain Water Bodies in Eastern Pamir Mountains (Tajikistan)

ABSTRACT In mountain desert ecosystems, wetlands around saline and freshwater lakes allow various organisms to thrive and sometimes serve as the only source of drinking water for wild and domestic animals. We present results concerning diversity and structure of cyanobacterial inoculum from Eastern Pamir Mountains' benthic sediments, collected from small water bodies with contrasting salinity, temperature and other chemical parameters. We used morphological identification and molecular NGS techniques based on the amplification of the V3-V4 hypervariable region of 16S rRNA gene. Only a few cyanobacterial taxa have been identified in the preserved samples, while 27 taxa were successfully isolated and identified from the benthic sediments. Metagenomic analysis revealed that the cyanobacterial contribution to benthic bacterial communities was low. Representatives of the order Nostocales dominated in the samples, followed by Synechococcales, while contributions of Oscillatoriales and Chroococcales was much lower. The correlation matrix for the amplicon-based composition of samples clustered together samples of similar salinity and temperature. However, in hierarchical clustering of taxonomic structure of samples, communities with similar structures were not grouped by salinity or temperature. These results suggest that salinity and to some extent temperature, influence the composition of the inoculum, although the structure of the cyanobacterial communities is further shaped by other factors. Our study also demonstrated that the benthic inoculum for cyanobacterial communities contained potentially toxic taxa characteristic of both benthic and planktonic communities.
Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk

Regardless of the promising results of certain immune checkpoint blockers, current immunotherapeutics have met a bottleneck concerning response rate, toxicity, and resistance in lung cancer patients. Accumulating evidence forecasts that the crosstalk between tumor and immune cells takes center stage in cancer development by modulating tumor malignancy, immune cell infiltration, and immune evasion in the tumor microenvironment (TME). Cytokines and chemokines secreted by this crosstalk play a major role in cancer development, progression, and therapeutic management. An increased infiltration of Tumor-associated macrophages (TAMs) was observed in most of the human cancers, including lung cancer. In this review, we emphasize the role of cytokines and chemokines in TAM-tumor cell crosstalk in the lung TME. Given the role of cytokines and chemokines in immunomodulation, we propose that TAM-derived cytokines and chemokines govern the cancer-promoting immune responses in the TME and offer a new immunotherapeutic option for lung cancer treatment.
Differentiating Experience From Cue Utilization in Radiological Assessments

Objective This research was designed to examine the contribution of self-reported experience and cue utilization to diagnostic accuracy in the context of radiology. Background Within radiology, it is unclear how task-related experience contributes to the acquisition of associations between features with events in memory, or cues, and how they contribute to diagnostic performance. Method Data were collected from 18 trainees and 41 radiologists. The participants completed a radiology edition of the established cue utilization assessment tool EXPERTise 2.0, which provides a measure of cue utilization based on performance on a number of domain-specific tasks. The participants also completed a separate image interpretation task as an independent measure of diagnostic performance. Results Consistent with previous research, a k-means cluster analysis using the data from EXPERTise 2.0 delineated two groups, the pattern of centroids of which reflected higher and lower cue utilization. Controlling for years of experience, participants with higher cue utilization were more accurate on the image interpretation task compared to participants who demonstrated relatively lower cue utilization (p = .01). Conclusion This study provides support for the role of cue utilization in assessments of radiology images among qualified radiologists. Importantly, it also demonstrates that cue utilization and self-reported years of experience as a radiologist make independent contributions to performance on the radiological diagnostic task. Application Task-related experience, including training, needs to be structured to ensure that learners have the opportunity to acquire feature–event relationships and internalize these associations in the form of cues in memory.
COVID‐19 Presents High Risk to Older Persons

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in an unprecedented shutdown in social and economic activity with the cultural sector particularly severely affected Restrictions on performance have arisen from a perception that there is a significantly higher risk of aerosol production from singing than speaking based upon high-profile examples of clusters of COVID-19 following choral rehearsals However, no direct comparison of aerosol generation from singing and speaking has been reported Here, we measure aerosols from singing, speaking and breathing in a zero-background environment, allowing unequivocal attribution of aerosol production to specific vocalisations Speaking and singing show steep increases in mass concentration with increase in volume (spanning a factor of 20-30 across the dynamic range measured, p-5) At the quietest volume (50 to 60 dB), neither singing (p=0 19) or speaking (p=0 20) were significantly different to breathing At the loudest volume (90 to 100 dB), a statistically significant difference (p-5) is observed between singing and speaking, but with singing only generating a factor of between 1 5 and 3 4 more aerosol mass Guidelines should create recommendations based on the volume and duration of the vocalisation, the number of participants and the environment in which the activity occurs, rather than the type of vocalisation Mitigations such as the use of amplification and increased attention to ventilation should be employed where practicable
Men’s Hostile Sexism and Biased Perceptions of Partners’ Support: Underestimating Dependability Rather Than Overestimating Challenges to Dominance

Hostile sexism expresses derogation of women’s competence and emphasizes that women will exploit men’s relational dependence. Men who endorse hostile sexism perceive their female partners more negatively, but do these negative perceptions stem from motives for dominance or insecurities about dependence? We tested both perspectives by assessing bias in perceptions of partners’ behaviors that challenge dominance (criticism, instruction, taking over) versus affirm partners are dependable (love, care, availability). Both members of 100 heterosexual couples reported how much they received and enacted these behaviors in (a) a lab-based discussion and (b) six monthly retrospective reports about an ongoing important goal. In both support contexts, men’s hostile sexism was associated with underestimating dependability-relevant support, particularly when partners reported providing low support. This pattern did not emerge for dominance-relevant behaviors. These results indicate that men’s hostile sexism involves insecurities about dependence, producing perceptions that female partners are less dependable than they actually are.
Kecukupan zat gizi makro, status gizi, stres, dan siklus menstruasi pada remaja

Background: Adolescence is the transition period from children to adults which is characterized by the occurrence of changes in the body that allowed it to reproductive health problems. One of reproductive health problems is menstrual cycle disorders. Menstrual cycle disorder due to several factors including food intake, nutritional status, and stress. Objective: This research supposed to know the association the sufficient of macro-nutrients, nutritional status and stress with the menstrual cycle on adolescent at SMA Negeri Jakarta 21, 2016. Method: This design research is observation analytic with cross sectional approach. Sampling technique used proportionate random sampling and obtained 83 respondents adolescent. The technique of data collection used menstrual cycle questionnaire, DASS 14, food recall 3x24 hours (2 weekdays and 1 weekend), standardized food ingredient photos, and nutrisurvey. Results: There is 68.7% of respondents have an abnormal menstrual cycle. Based on statistical analysis of Chi-Square test, there is a significant relation between sufficient intake of carbohydrates (p=0.030), sufficient intake of protein (p=0.001), sufficient intake of fat (p=0.003), nutritional status (p=0,004), stress (p=0.000) and menstrual cycle. Based on logistic regression test results obtained the factors that most influence the menstrual cycle i.e. nutritional status (OR=20.16). Conclusion: Sufficient intake of macronutrients, nutritional status, and stress can affect menstrual cycle on adolescent, and nutritional status is the dominant factor that can affect the menstrual cycle.
Optofluidic control of rodent learning using cloaked caged glutamate

Significance Caged glutamates are photolabile compounds that are widely used by neuroscientists. However, these probes have off-target pharmacological side effects, in that they block inhibitory neurotransmitter receptors. We have developed a caged glutamate molecule decorated with a large dendrimer cloak that prevents such blockade. This photoprobe is an example of a caged glutamate that is fully biologically inert. We combine this compound with the newly developed technique of optofluidics, which allows us deliver the probe with simultaneous photolysis in freely moving mice. Uncaging in the brain region involved in the reward pathway mediated Pavlovian conditioning during a behavioral test. This work forms a useful paradigm for future experiments involving real-time phasic manipulation of the behavior of higher-order animals Glutamate is the major excitatory neurotransmitter in the brain, and photochemical release of glutamate (or uncaging) is a chemical technique widely used by biologists to interrogate its physiology. A basic prerequisite of these optical probes is bio-inertness before photolysis. However, all caged glutamates are known to have strong antagonism toward receptors of γ-aminobutyric acid, the major inhibitory transmitter. We have developed a caged glutamate probe that is inert toward these receptors at concentrations that are effective for photolysis with violet light. Pharmacological tests in vitro revealed that attachment of a fifth-generation (G5) dendrimer (i.e., cloaking) to the widely used 4-methoxy-7-nitro-indolinyl(MNI)-Glu probe prevented such off-target effects while not changing the photochemical properties of MNI-Glu significantly. G5-MNI-Glu was used with optofluidic delivery to stimulate dopamine neurons of the ventral tegmental area of freely moving mice in a conditioned place-preference protocol so as to mediate Pavlovian conditioning.