Miracle-dz/UniFAR-FTUs huggingface dataset:
Revisit of the CatLet (Hexu) angiographic scoring system: a narrative review

Background and Objective We have recently developed the Coronary Artery Tree description and Lesion EvaluaTion (CatLet or Hexu, invented by He and Xu) angiographic scoring system, which, considering the coronary anatomy in its diversity, the stenosis degree of a coronary artery, and the myocardial territory subtended by the diseased coronary artery, can be utilized to predict clinical outcomes for patients with acute myocardial infarction (available at www.catletscore.com). Its values for clinical practice and coronary artery disease research are building upon. Over the past two years, the principles underlying this novel angiographic scoring system do not materially change although slight adjustments have really happened. Given these adjustments and the scoring experience gained in daily use, we think that it is necessary to elaborate on these points so that readers with interest are capable to better use this CatLet or Hexu angiographic scoring system both in clinical practice and in scientific research. Methods The principles underlying this novel angiographic scoring system include the 17-myocardial segmental model, law of competitive blood supply, and law of flow conservation. Key Content and Findings The adjustments made to this novel angiographic scoring system include: (I) the short axis of the left ventricle at the basal level is used to characterize the six types of right coronary artery size; (II) segments marked with ’X and ’S have a unified preset difference of one segment as adopted in the characterization of left anterior descending artery; (III) segments marked with ’+ have been added to explain the rare variability in the obtuse marginal branches or in the posterolateral vessels in some cases. The CatLet or Hexu angiographic scoring system strictly follows the law of flow conservation in weighting assignment, and the lesion scoring correction has been additionally emphasized and detailed. Conclusions The elaboration on these adjustments and scoring experience gained on the CatLet or Hexu angiographic scoring system will help to boost its use in cardiovascular field. The utilities of this novel angiographic scoring system have been preliminarily validated and its future is deserving of being anticipated.
Complete geometric invariant study of two classes of quadratic systems

In this paper we give a complete study using affine invariant conditions for the quadratic systems having centers. Independently we do the same for quadratic systems being Hamiltonian. There are two improvements of the previous results as [29] in which centers where study up to GL-invariant, and of [1] in which Hamiltonian QS where classified without invariants. The geometrical affine invariant study we present here is a crucial step for a bigger goal which is a complete affine invariant algebraic classification of the whole family of quadratic systems according to all their singular points (finite and infinite).
Pro- and Antioxidant Effect of Food Items and Matrices during Simulated In Vitro Digestion

The digestive tract can be considered a bioreactor. High levels of reactive oxygen species (ROS) during digestion may predispose for local and/or systemic oxidative stress and inflammation, e.g., inflammatory bowel diseases. Food items rich in antioxidants may prevent such aggravation. This investigation analyzed pro-and antioxidant patterns of food matrices/items following in vitro digestion. Gastrointestinal digestion reflecting typically consumed quantities was performed on nine food items (orange and tomato juice, soda, coffee, white chocolate, sausage, vitamin C and E, and curcumin) and their combinations (n = 24), using the INFOGEST model. Antioxidant potential was measured by FRAP, DPPH, and ABTS, and pro-oxidant aspects by MDA (malondialdehyde) and peroxide formation. An anti-pro-oxidant score was developed, combining the five assays. Liquid food items showed moderately high antioxidant values, except for coffee and orange juice, which exhibited a high antioxidant potential. Solid matrices, e.g., white chocolate and sausage, showed both high pro-oxidant (up to 22 mg/L MDA) and high antioxidant potential (up to 336 mg/L vitamin C equivalents) at the same time. Individual vitamins (C and E) at physiological levels (achievable from food items) showed a moderate antioxidant potential (<220 mg/L vitamin C equivalents). Overall, both antioxidant and pro-oxidant assays correlated well, with correlation coefficients of up to 0.894. The effects of food combinations were generally additive, i.e., non-synergistic, except for combinations with sausage, where strong quenching effects for MDA were observed, e.g., with orange juice. In conclusion, as especially highlighted by complex matrices demonstrating both pro- and antioxidant potential, only measuring one aspect would result in physiological misinterpretations. Therefore, it is imperative to employ a combination of assays to evaluate both pro- and antioxidant properties of food digesta to ensure physiological relevance.
New data on minerals with the GIS framework-type structure: gismondine-Sr from the Bellerberg volcano, Germany, and amicite and Ba-rich gismondine from the Hatrurim Complex, Israel

Abstract Gismondine-Sr, recently discovered in the Hatrurim Complex in Israel, has been recognised in a xenolith sample from the Bellerberg volcano in Germany. The empirical crystal-chemical formula indicates elevated K content: (Sr1.74Ca1.05Ba0.09K1.56Na0.49)Σ4. 93[Al7.98Si8. 06O32]⋅9.62H2O. Additionally, Ba-rich gismondine and amicite have been found in the low-temperature mineral association of the pyrometamorphic rock from the Hatrurim Complex. The Raman spectra of the studied zeolites and the crystal structure of gismondine-Sr from the second occurrence are presented. A review of zeolites with GIS framework-type structure leads to the following conclusions: (1) garronite-Na and gobbinsite are equivalent and constitute a solid solution with garronite-Ca; (2) gismondine-Ca, -Sr, and amicite belong to one mineral series; (3) two zeolites series with different R-factors (defined as Si/(Si+Al+Fe)) can be distinguished within GIS topology: the garronite series (R > 0.6) including garronite-Ca and gobbinsite, with general formula (MyD0.5(x–y))[AlxSi(16–x)O32]⋅nH2O, where M and D refer to monovalent and divalent cations, respectively; and the gismondine series, including amicite, gismondine-Sr and gismondine-Ca, with R ≈ 0.5, and the general formula (MyD0.5(8–y))[Al8Si8O32]⋅nH2O. The Raman band between 475 cm–1 and 485 cm–1 is distinctive for the garronite series, whereas the band around 460 cm–1 is characteristic of the gismondine series. On the basis of these findings, a revision of GIS zeolites nomenclature is suggested.
Factors associated with severe maternal, fetuses and neonates’ outcomes in a university hospital in Rio de Janeiro State

Abstract Objectives: to estimate the burden of parturients, fetuses and neonate’s severe morbidity and mortality and investigate the association between maternal and their conceptus outcomes. Methods: retrospective cohort of 546 parturients and their conceptus in a university hospital, reference for high-risk pregnancy, in the metropolitan region II of Rio de Janeiro State from 2015 to 2017. We classified parturients according to obstetric morbidity (OM) in direct, indirect, or mixed, and their outcomes as: 1) no severity, 2) severe complication (SC), 3) critical intervention/Intensive Care Unit, and 4) greater severity –maternal near-miss (MNM) or death. We evaluated the conceptus as neonatal near-miss (NNM) and fetal and neonatal deaths. We estimated morbimortality indicators and associated factors (multinomial logistic regression). Results: OM was frequent: 29.3% indirect, 22.3% direct, and 15.8% mixed. There were eight cases of NMM, seven with direct MO. Among the conceptus: 7.5% were NNM cases and 4.4%, deaths. The risk of severe maternal outcomes was 16.8 and neonatal, 102.6/1000 live births. Mixed race, inadequate prenatal care, CG and NMM/death, were associated with NNM. Inadequate prenatal care and maternal NM/death were associated with conceptus deaths. Conclusion: even in a reference unit, sociodemographic, and health care inequalities negatively affect mothers and, consequently, their children.
Linearized Unsteady Viscous Turbomachinery Flows Using Hybrid Grids

The paper describes the theory and the numerical implementation of a three-dimensional finite volume scheme for the solution of the linearized, unsteady Favre-averaged Navier-Stokes equations for turbomachinery applications. A further feature is the use of mixed element grids, consisting of triangles and quadrilaterals in two dimensions, and of tetrahedra, triangular prisms, and hexahedra in three dimensions. The linearized unsteady viscous flow equations are derived by assuming small harmonic perturbations from a steady-state flow and the resulting equations are solved using a pseudo-time marching technique. Such an approach enables the same numerical algorithm to be used for both the nonlinear steady and the linearized unsteady flow computations. The important features of the work are the discretization of the flow domain via a single, unified edge-data structure for mixed element meshes, the use of a Laplacian operator, which results in a nearest neighbor stencil, and the full linearization of the Spalart-Allmaras turbulence model. Four different test cases are presented for the validation of the proposed method. The first one is a comparison against the classical subsonic flat plate cascade theory, the so-called LINSUB benchmark. The aim of the second test case is to check the computational results against the asymptotic analytical solution derived by Lighthill for an unsteady laminar flow. The third test case examines the implications of using inviscid, frozen-turbulence, and fully turbulent models when linearizing the unsteady flow over a transonic turbine blade, the so-called 11th International Standard Configuration. The final test case is a rotor/stator interaction, which not only checks the validity of the formulation for a three-dimensional example, but also highlights other issues, such as the need to linearize the wall functions. Detailed comparisons were carried out against measured steady and unsteady flow data for the last two cases and good overall agreement was obtained.
Predicting shapes of hysteresis loops on the output of tunable external-cavity semiconductor lasers

Studies have been made of the nonlinear characteristics of grating tuned external-cavity semiconductor lasers with the aid of the analytical expression of the threshold carrier density required for the laser to oscillate at different frequencies. After connecting refractive index with carrier density through the spectral broadening factor and choosing an appropriate reference carrier density, the key points defining hysteresis loops on the N-/spl nu/ (carrier density-frequency) curves have been determined analytically. Consequently, different shapes of hysteresis loops on P-/spl nu/ (power-frequency) curves have been predicted. The validity of the theory has been examined using the data provided by different papers.
Towards a strontium optical lattice clock

Due to the recent success, in terms of accuracy and precision, of a number of strontium optical lattice optical frequency standards, and the classification of the 5 s 2 1 S 0 to 5 s 5 p 3 P 0 transition in neutral strontium as a secondary definition of the SI unit of the second, many new strontium lattice clocks are under development. The strontium optical lattice clock (Sr OLC) at the National Physical Laboratory (NPL) is one such project. This thesis describes the design and build of the NPL Sr OLC, discussing the considerations behind the design. Details of the first cooling stage are given, which includes the characterisation of a novel permanent-magnet Zeeman slower by measurements of the longitudinal velocity distributions and loading of the MOT at 461 nm. Development of a narrow linewidth laser system at 689 nm is described, which is used for initial spectroscopy of the second-stage cooling transition. In particular, this work describes progress towards two independent ultra-narrow linewidth clock lasers. The new generation of strontium lattice clock experiments have focused on characterising the systematic frequency shifts and reducing their associated fractional frequency uncertainties, as well as reducing the fractional frequency instability of the measurement. One focus of the Sr OLC at NPL is to help characterise the frequency shift of the clock transition due to black-body radiation (BBR), which is currently the largest contributor to the uncertainty budget of the measured clock frequency. Our approach, discussed here, is to make a direct, differential measurement of the shift with the atoms housed alternately in environments of differing temperatures. Better characterisation and control of the BBR frequency shift of the strontium clock transition is crucial for the future of the Sr OLC as a leading frequency standard.
Dynamic Change of Novel Systemic Inflammation Markers to Predict Maternal-Neonatal Prognosis After Cervical Cerclage

Objective Cervical cerclage is an effective method to prevent preterm birth. However, the clinical indicators that can predict cervical cerclage remain limited. This study aimed to explore whether dynamically inflammatory markers are valuable biomarkers for the prognosis of cervical cerclage. Methods This study included 328 participants. Inflammatory markers were calculated using maternal peripheral blood before and after the cervical cerclage procedure. The Chi-square test, linear regression, and logistic regression were performed to evaluate the dynamic change of inflammatory markers with the prognosis of cervical cerclage. And the optimal cut-off values of inflammatory markers were calculated. Results Totally 328 pregnant women were analyzed in the study. 223 (67.99%) participants obtained successful cervical cerclage. This study revealed that the maternal age, the baseline BMI (cm2/kg), the times of gravida, the rate of recurrent abortion, the PPROM, cervical length shorter (<1.5cm), cervical dilation (≥2cm), the bulging membrane, the Pre-SII, the Pre-SIRI, the Post-SII, the Post-SIRI, and the ΔSII were significantly associated with outcomes after cervical cerclage (all P<0.05). Pre-SII, Pre-SIRI, Post-SII, Post-SIRI, and ΔSII levels were mainly related to maternal-neonatal outcomes. Furthermore, the results demonstrated that the ΔSII level had the highest OR (OR=14.560; 95% CI (4.461–47.518)). In addition, we revealed that Post-SII and ΔSII levels had the highest AUC (0.845/0.840) and relatively higher sensitivity/specificity (68.57/92.83% and 71.43/90.58%) and PPV/ NPV (81.82/86.25% and 78.13/87.07%) compared with other indicators. Conclusion This study suggested that the dynamic change of SII level and SIRI level are important biochemical markers to predict the prognosis of cervical cerclage and maternal-neonatal prognosis, especially the Post-SII and ΔSII levels. They can help to determine candidates for cervical cerclage before surgical procedure and enhance postoperative surveillance.
Effect of Exercise on Liver Function and Insulin Resistance Markers in Patients with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background: Structured exercise as part of lifestyle modification plays an important role in the improvement of non-alcoholic fatty liver disease (NAFLD); however, its effectiveness has been shown to vary. This systematic review with meta-analysis investigated the effects of exercise on liver function and insulin resistance markers in patients with NAFLD. Methods: Six electronic databases were searched using terms related to exercise and NAFLD up to March 2022. Data were analyzed using a random-effects model to estimate the standardized mean difference (SMD) and 95% confidence interval. Results: The systematic search identified 2583 articles, of which a total of 26 studies met the inclusion criteria and were eligible. Exercise training had a moderate effect on reducing ALT (SMD: −0.59, p = 0.01) and small effects on reducing AST (SMD: −0.40, p = 0.01) and insulin (SMD: −0.43, p = 0.02). Significant reductions in ALT were found following aerobic training (SMD: −0.63, p < 0.01) and resistance training (SMD: −0.45, p < 0.001). Moreover, reductions in AST were found following resistance training (SMD: −0.54, p = 0.001), but not after aerobic training and combined training. However, reductions in insulin were found following aerobic training (SMD: −0.55, p = 0.03). Exercise interventions for <12 weeks compared to ≥12 weeks were more effective in reducing FBG and HOMA-IR, while interventions for ≥12 weeks compared to <12 weeks were more effective in reducing ALT and AST levels. Conclusions: Our findings support the effectiveness of exercise in improving liver function markers but not in blood glucose control in NAFLD patients. Additional studies are needed to determine the exercise prescription to maximize health in these patients.
High-Intensity Training for Knee Osteoarthritis: A Narrative Review

Knee osteoarthritis (OA) is the most common joint disease worldwide. Exercise therapy has been identified as a first-line treatment option in patients suffering from knee OA. High-intensity training (HIT) is an innovative exercise modality with potential in improving various disease-related outcomes. The purpose of this review is to explore the impact of HIT on knee OA symptoms and physical functioning. A comprehensive search of scientific electronic databases was conducted to identify articles on the effects of HIT on knee OA. Thirteen studies were included in this review. Ten compared the effects of HIT with those of low-intensity training, moderate-intensity continuous training, or a control group. Three evaluated the effects of HIT alone. Eight reported a decrease in knee OA symptoms (especially pain), and eight reported an increase in physical functioning. HIT was shown to improve knee OA symptoms and physical functioning, but also aerobic capacity, muscle strength, and quality of life with minimal or no adverse events. However, compared with other exercise modalities, no clear superiority of HIT was found. HIT is a promising exercise strategy in patients with knee OA; nonetheless, the actual quality of evidence remains very low, and more high-quality studies are needed to confirm these promising outcomes.
Hearing loss classification via AlexNet and Support Vector Machine

This paper presents a new method for detecting hearing loss. Our approach is first to use AlexNet to extract the features. Then, we use the Support Vector Machine as a classifier to classify the images. 10-fold cross-validation results showed that the sensitivities of the healthy control group, the left-sided hearing loss group, and the right-sided hearing loss group in this method were 94.67%, 94.00%, and 95.17%, respectively, achieving a very good effect compared with other hearing loss detection methods. In conclusion, our method is effective for the identification of hearing loss.
Arsenic Trioxide: Pharmacological Applications

Background: Arsenic trioxide is a chemical compound that has been used as a treatment for various diseases. Despite being potentially toxic, this compound has been used as a therapy to treat Acute Myeloid Leukemia and is being investigated as a possible treatment for different types of cancer. Objectives: The present review aims to describe the use and studies reported in the literature of Arsenic Trioxide as a possible therapeutic agent for Acute Myeloid Leukemia, Acute Promyelocytic Leukemia, Chronic Myeloid Leukemia, Multiple Myeloma, Myelodysplastic Syndrome, Hepatocellular Carcinoma, Lung Cancer, Neuroblastoma, Breast Cancer, Aplastic Hepatitis C, and HIV-1. Methods: A systematic review was conducted using databases (Elsevier, Google Scholar, PubMed) to compile documents published before December 2023. Results: Multiple pharmacological applications of arsenic trioxide have been reported to treat acute and chronic myeloid leukemia. Arsenic trioxide has been shown to inhibit angiogenesis, which helps treat multiple myeloma. Several studies have shown and suggested the effectiveness of arsenic trioxide as a treatment of hepatocellular carcinoma, lung cancer, neuroblastoma, prostate cancer, breast cancer, aplastic anemia, hepatitis C, and HIV-1.Conclusion: Despite potentially toxic effects, Arsenic compounds are therapeutic agents for multiple diseases, from syphilis to cancer. In recent years, more efficient ways have been investigated to deliver and find the specific dose to treat the disease, causing the fewest possible adverse effects.
Indirect Methods to Determine the Risk of Damage to the Health of Firefighters and Children Due to Exposure to Smoke Emission from Burning Wood/Coal in a Controlled Environment

People are constantly exposed to particulate matter and chemicals released during fires. However, there are still few studies on gas and particulate emissions related to exposure to burning firewood and charcoal during forest fires, making it difficult to understand the effects on the health of the population. The objective of this study was to quantify the metal(loid)s present in the smoke from wood and charcoal fires through the deposition of metals in beef topside and pork loin, considering the routes of skin exposure, inhalation, and ingestion, contributing to the understanding of metals in the increase of the risks of cancer and mortality associated with firefighting and children. The concentrations of metals [aluminum (Al), chromium (Cr), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), molybdenum (Mo), vanadium (V), zinc (Zn)] and metalloids arsenic (As) were determined by inductively coupled plasma–mass spectrometry (ICP OES) after microwave digestion. Moreover, we assessed the associated risk regarding the elemental intake of these elements through the smoke, using the hazard quotient (HQ), hazard index (HI), Total Hazard Index (HIt), and carcinogenic risk (CR). All samples had results for HQ and HIt < 1, indicating a non-potential health risk. However, the carcinogenic risks posed by As and Cr via the three exposure pathways (except for inhalation exposure to children and adults, and by Cr via ingestion and inhalation for children and adults) exceeded the standard threshold. In conclusion, continuous exposure of firefighters or children to smoke from fires containing high concentrations of heavy metals such as As and Cr can be harmful to health. The study used animal tissues; thus, new methods must be developed to quantify the concentration of heavy metals deposited in human tissue when humans are exposed to smoke from fires.