Miracle-dz/UniFAR-FTUs huggingface dataset:
The new evidence on cardiorenal benefits of sodium-glucose cotransporter 2 inhibitors in type 1 diabetes: one step closer to their use in this setting?

ABSTRACT Chronic kidney disease (CKD) affects 30–40% of persons with type 1 diabetes mellitus (T1DM), markedly increasing the risk of kidney failure and cardiovascular events. The excessive mortality observed in T1DM compared to the general population can be attributed to the presence of CKD, with cardiovascular disease as the leading cause of premature death. A recently published, robust real-world study investigated the impact of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) adjunctive therapy on blood glucose levels, adverse events, and cardio-renal outcomes among individuals with T1DM. GLP-1 RA provided greater reduction in glycated hemoglobin in comparison to SGLT2i therapy, whereas the latter reduced the risk of CKD, heart failure, and hospitalization for any cause. However, the SGLT2i treated cohort had a higher risk of diabetic ketoacidosis (DKA). The study provides promising evidence that the protective cardiorenal effects of SGLT2i, previously confirmed in people with and without type 2 diabetes mellitus, might also be present in T1DM. However, the benefits and risks, especially the risk of DKA, should be further examined in dedicated large-scale randomized controlled trials.
The future of postoperative vital sign monitoring in general wards: improving patient safety through continuous artificial intelligence-enabled alert formation and reduction

Purpose Monitoring of vital signs at the general ward with continuous assessments aided by artificial intelligence (AI) is increasingly being explored in the clinical setting. This review aims to describe current evidence for continuous vital sign monitoring (CVSM) with AI-based alerts − from sensor technology, through alert reduction, impact on complications, and to user-experience during implementation. Recent findings CVSM identifies significantly more vital sign deviations than manual intermittent monitoring. This results in high alert generation without AI-evaluation, both in patients with and without complications. Current AI is at the rule-based level, and this potentially reduces irrelevant alerts and identifies patients at need. AI-aided CVSM identifies complications earlier with reduced staff workload and a potential reduction of severe complications. Summary The current evidence for AI-aided CSVM suggest a significant role for the technology in reducing the constant 10–30% in-hospital risk of severe postoperative complications. However, large, randomized trials documenting the benefit for patient improvements are still sparse. And the clinical uptake of explainable AI to improve implementation needs investigation.
The Potential Hepatoprotective Effect of Vaccinium arctostaphylos L. Fruit Extract in Diabetic Rat

Objective: Vaccinium arctostaphylos has traditionally been employed in Iranian folk medicine to treat diabetes. However, the precise molecular mechanisms underlying its antidiabetic properties remain incompletely understood. The current experiment intended to explore the modulatory effects of V. arctostaphylos fruit ethanolic extract (VAE) on biochemical and molecular events in the livers of diabetic rats. Materials and Methods: In this experimental study, male Wistar rats were randomly assigned to four groups: normal control, normal rats with VAE treatment, diabetic control, and diabetic rats with VAE treatment. Following 42 days of treatment, the impact of VAE on diabetes-induced rats was assessed by measuring various serum biochemical parameters, including insulin, free fatty acids (FFA), tumor necrosis factor-α (TNF-α), reactive oxygen species (ROS), and adiponectin levels. The activities of hepatic carbohydrate metabolic enzymes and glycogen content were determined. Additionally, expression levels of selected genes implicated in carbohydrate/lipid metabolism and miR-27b expression were evaluated. H&E-stained liver sections were prepared for light microscopy examination. Results: Treatment with VAE elevated levels of insulin and adiponectin that reduced levels of FFA, ROS, and TNF-α in the serum of diabetic rats. VAE-treated rats exhibited increased activities of hepatic glucokinase (GK), glucose-6-phosphate dehydrogenase (G6PD), and glycogen concentrations, in conjunction with decreased activities of glucose-6-phosphatase (G6Pase) and fructose-1,6-bisphosphatase (FBPase). Furthermore, VAE significantly upregulated the transcription levels of hepatic insulin receptor substrate 1 (Irs1) and glucose transporter 2 (Glut2), while considerably downregulated the expression of peroxisome proliferator-activated receptor gamma (Pparg) and sterol regulatory element-binding protein 1c (Srebp1c). VAE remarkably enhanced the expression of miR27-b in the hepatic tissues of diabetic rats. Abnormal histological signs were dramatically normalized in diabetic rats receiving VAE compared to those in the diabetic control group. Conclusion: Our findings underscore the hypoglycemic and hypolipidemic activities of V. arctostaphylos and assist in better comprehension of its antidiabetic properties.
DNA methylation differences between stick insect ecotypes

Epigenetic mechanisms, such as DNA methylation, can influence gene regulation and affect phenotypic variation, raising the possibility that they contribute to ecological adaptation. Beginning to address this issue requires high‐resolution sequencing studies of natural populations to pinpoint epigenetic regions of potential ecological and evolutionary significance. However, such studies are still relatively uncommon, especially in insects, and are mainly restricted to a few model organisms. Here, we characterize patterns of DNA methylation for natural populations of Timema cristinae adapted to two host plant species (i.e. ecotypes). By integrating results from sequencing of whole transcriptomes, genomes and methylomes, we investigate whether environmental, host and genetic differences of these stick insects are associated with methylation levels of cytosine nucleotides in the CpG context. We report an overall genome‐wide methylation level for T. cristinae of ~14%, with methylation being enriched in gene bodies and impoverished in repetitive elements. Genome‐wide DNA methylation variation was strongly positively correlated with genetic distance (relatedness), but also exhibited significant host‐plant effects. Using methylome‐environment association analysis, we pinpointed specific genomic regions that are differentially methylated between ecotypes, with these regions being enriched for genes with functions in membrane processes. The observed association between methylation variation and genetic relatedness, and with the ecologically important variable of host plant, suggests a potential role for epigenetic modification in T. cristinae adaptation. To substantiate such adaptive significance, future studies could test whether methylation can be transmitted across generations and the extent to which it responds to experimental manipulation in field and laboratory studies.
Acute kidney injury after cardiac surgery

Purpose of review Patients undergoing cardiac surgery are at high risk to develop cardiac surgery-associated acute kidney injury (CS-AKI) postoperatively. CS-AKI is associated with an increased risk for persistent renal dysfunction, morbidity and mortality. This review summarizes the epidemiology and pathophysiology of CS-AKI, as well as current treatment and prevention strategies. Recent findings As AKI is a syndrome with complex pathophysiology, no causative treatment strategies exist. Recent advances in the field of AKI biomarkers offer new perspectives on the issue and the implementation of biomarker-guided preventive strategies may reduce rates of CS-AKI. Finally, nephroprotective treatments and angiotensin II as a novel vasopressor may offer new opportunities for high-risk patients undergoing cardiac surgery. Summary Based on the described novel approaches for early detection, prevention and management of CS-AKI, a precision-medicine approach should be implemented in order to prevent the development of AKI in patients undergoing cardiac surgery.
Should AMOC observations continue: how and why?

The Atlantic meridional overturning circulation (AMOC) is a large-scale circulation pattern responsible for northward heat transport in the Atlantic and is associated with climate variations on a wide range of time scales. Observing the time-varying AMOC has fundamentally changed our understanding of the large-scale ocean circulation and its interaction with the climate system, as well as identified shortcomings in numerical simulations. With a wide range of gains already achieved, some now ask whether AMOC observations should continue. A measured approach is required for a future observing system that addresses identified gaps in understanding, accounts for shortcomings in observing methods and maximizes the potential to guide improvements in ocean and climate models. Here, we outline a perspective on future AMOC observing and steps that the community should consider to move forward. This article is part of a discussion meeting issue ‘Atlantic overturning: new observations and challenges’.
Observed mechanisms activating the recent subpolar North Atlantic Warming since 2016

The overturning circulation of the subpolar North Atlantic (SPNA) plays a fundamental role in Earth’s climate variability and change. Here, we show from observations that the recent warming period since about 2016 in the eastern SPNA involves increased western boundary density at the intergyre boundary, likely due to enhanced buoyancy forcing as a response to the strong increase in the North Atlantic Oscillation since the early 2010s. As these deep positive density anomalies spread southward along the western boundary, they enhance the North Atlantic Current and associated meridional heat transport at the intergyre region, leading to increased influx of subtropical heat into the eastern SPNA. Based on the timing of this chain of events, we conclude that this recent warming phase since about 2016 is primarily associated with this observed mechanism of changes in deep western boundary density, an essential element in these interactions. This article is part of a discussion meeting issue ‘Atlantic overturning: new observations and challenges’.
Overturning in the subpolar North Atlantic: a review

The Overturning in the Subpolar North Atlantic Program (OSNAP) was initiated in the spring of 2010 through a collaborative effort involving the USA, the UK, Germany, the Netherlands and Canada. A key feature of OSNAP is a trans-basin observing system deployed in the summer of 2014 for the continuous measure of volume, heat and freshwater fluxes in the subpolar North Atlantic. This review focuses on advancements made possible by the collective OSNAP observations. Chief among those advancements is the quantification of the dominant role of the eastern subpolar North Atlantic in the production of dense waters that reside in the lower limb of the overturning: the Irminger and Iceland basins contributed approximately three times as much dense water compared with the Labrador Sea over the observational period. Other advancements include elucidation of the relationship between convective activity in the basin interior and boundary current anomalies; the spread of overflow waters in the subpolar region; the seasonality of the meridional volume, heat and freshwater fluxes; and the challenges involved in designing a simpler, less costly observing system. Collectively, OSNAP measurements are laying a framework on which to assess the overturning circulation's vulnerability to continued warming and freshening as climate change continues apace. This article is part of a discussion meeting issue ‘Atlantic overturning: new observations and challenges’.
Reviving Dead Links on the Web with Fable

The web is littered with millions of links which previously worked but no longer do. When users encounter any such broken link, they resort to looking up an archived copy of the linked page. But, for a sizeable fraction of these broken links, no archived copies exist. Even if a copy exists, it often poorly approximates the original page, e.g., any functionality on the page which requires the client browser to communicate with the page's backend servers will not work, and even the latest copy will be missing updates made to the page's content after that copy was captured. To address this situation, we observe that broken links are often merely a result of website reorganizations; the linked page still exists on the same site, albeit at a different URL. Therefore, given a broken link, our system FABLE attempts to find the linked page's new URL by learning and exploiting the pattern in how the old URLs for other pages on the same site have transformed to their new URLs. We show that our approach is significantly more accurate and efficient than prior approaches which rely on stability in page content over time. FABLE increases the fraction of dead links for which the corresponding new URLs can be found by 50%, while reducing the median delay incurred in identifying the new URL for a broken link from over 40 seconds to less than 10 seconds.
On the Similarity of Web Measurements Under Different Experimental Setups

Measurement studies are essential for research and industry alike better understand the Web's inner workings and help quantify specific phenomena. Performing such studies is demanding due to the dynamic nature and size of the Web. Designing and setting up an experiment is a complex task, and many factors might affect the results. However, while several works have independently observed differences in the outcome of an experiment (e.g., the number of observed trackers) based on the measurement setup, it is unclear what causes such deviations. This work investigates the reasons for these differences by visiting 1.7M webpages with five different measurement setups. Based on this investigation, we build 'dependency trees' for each page and cross-compare the nodes in the trees. The results show that the measured trees differ considerably, that the cause of differences can be attributed to specific nodes, and that even identical measurement setups can produce different results.
Modeling and Generating Control-Plane Traffic for Cellular Networks

With 5G deployment gaining momentum, the control-plane traffic volume of cellular networks is escalating. Such rapid traffic growth motivates the need to study the mobile core network (MCN) control-plane design and performance optimization. Doing so requires realistic, large control-plane traffic traces in order to profile and debug the mobile network performance under real workload. However, large-scale control-plane traffic traces are not made available to the public by mobile operators due to business and privacy concerns. As such, it is critically important to develop accurate, scalable, versatile, and open-to-innovation control traffic generators, which in turn critically rely on an accurate traffic model for the control plane. Developing an accurate model of control-plane traffic faces several challenges: (1) how to capture the dependence among the control events generated by each User Equipment (UE), (2) how to model the inter-arrival time and sojourn time of control events of individual UEs, and (3) how to capture the diversity of control-plane traffic across UEs. We present a novel two-level hierarchical state-machine-based control-plane traffic model. We further show how our model can be easily adjusted from LTE to NextG networks (e.g., 5G) to support modeling future control-plane traffic. We experimentally validate that the proposed model can generate large realistic control-plane traffic traces. We have open-sourced our traffic generator to the public to foster MCN research.
Poster: QUIC is not Quick Enough over Fast Internet

QUIC is a multiplexed transport-layer protocol over UDP and comes with enforced encryption. It is expected to be a game-changer in improving web application performance. Together with the network layer and layers below, UDP, QUIC, and HTTP/3 form a new protocol stack for future network communication, whose current counterpart is TCP, TLS, and HTTP/2. In this study, to understand QUIC's performance over high-speed networks and its potential to replace the TCP stack, we carry out a series of experiments to compare the UDP+QUIC+HTTP/3 (QUIC) stack and the TCP+TLS+HTTP/2 (HTTP/2) stack. Preliminary measurements on file download reveal that QUIC suffers from a data rate reduction compared to HTTP/2 across different hosts.
Intra-operative test electrode and electrical auditory brainstem response after preoperative assessment in cochlear implant candidacy

Abstract Introduction: Over the last years, in doubt of cochlear implant (CI) candidacy, assessment of excitability of the auditory nerve is performed with pre-operative tests. These tests are the pre-operative (pre-op.) performed electrical auditory brainstem (EABR) and the late response (EALR) recorded with trans-tympanic promontory stimulation in local anesthesia. But in some cases after such preoperative tests there is still doubt about the excitability of the auditory pathway. The most reliable EABR is recorded with using stimulation via the CI. However, before CI implantation,, an intra-cochlear test electrode could be used in order to achieve similar EABR results. Methods: In doubtful cases of patients who underwent pre-op. EABR, we performed EABR by a test electrode, part of the auditory nerve test system. This measurement was used to confirm the pre-operative results just before CI implantation. Additionally, EABR using CI stimulation was performed intra-operatively right after the CI implantation to confirm EABR using the test stimulation electrode results. Results: Six subjects were included in this study. They were tested by pre-op. EABR (n=6), pre-op. EALR (n=5), intra-op. EABR using test electrode (n=6), intraop. EABR via CI (n=6), and post-op. EABR (n=2), and postop. EALR (n=2). In two cases, intra-operative EABR showed a positive, i.e. clearly measureable, response whereas there was a doubtful response in pre-op. EABR. Intra-op. EABRs (test electrode and CI stimulation) showed the same results in all cases. Waveforms of EABR using test electrode look similar to EABR using CI stimulation but with more defined peaks compare to the pre-op. EABR. In one case with all-over positive EABR, pre-op. EALR, and post-operative EALR were matching. Conclusion: Intra-op. EABR using test electrode was easy to record and it shows similar results to EABR using CI stimulation. Intra-op. EABR using test electrode may help in confirming the results of not clear preop. EABR with a minimal increase in recording time.
Promoting speaking in the young learner classroom through task-based digital storytelling via online technology: a case study

Abstract In the young learner (YL) foreign language (FL) classroom, oracy is more important than literacy, but teaching speaking is still primarily repetitive in many contexts. Free speaking activities are difficult to create for teachers and accomplish for learners. This research investigated the ways in which imaginative digital storytelling (DST) tasks can improve oracy and the prior knowledge needed to negotiate meaning. The main data of this study, which were collected over one academic year, comprised a questionnaire of 19 Swiss Year 4 students, video and audio recordings of two dyads working on four collaborative oral DST tasks and a semi-structured interview with the four children and their class/English teacher. The results revealed that collaborative end-of-unit tasks enabled the children to creatively recycle the language learnt. Scaffolding and language support provided on the task sheet allowed a creative and personal approach to DST, which was a motivating experience. Clear guidance for classroom talk fostered collaboration and personal, social and problem-solving competences. These findings have implications for YL FL pedagogy and highlight the need for further theoretical insights into task-based DST.
The effects of flooding disturbance on the distribution and behaviour of riparian arthropods along a lowland gravel river

This Ph.D.-thesis aimed to address which environmental factors influence the assemblage structure of mobile, riparian arthropods along spatially structured river banks of a rain-fed, lowland gravel river, the Common Meuse. As riverine ecosystems are basically non-equilibrium, dynamic ecosystems, mainly flow regimes and flood pulse characteristics are expected to shape both the distribution and behaviour of its inhabitants. The river banks along the Common Meuse are (in)frequently disturbed by flood events and liable to extreme microclimatological conditions. Hence, functional life-history traits of the present species, particularly spiders (Araneae) and carabid beetles (Carabidae), supposedly affect species composition as well. Moreover, organisms occurring within a highly structured system and which are repeatedly exposed to flooding disturbance, are expected to have evolved or adjusted their behavioural responses in accordance with their functional life-history characteristics such as habitat affinity and mobility. Correspondingly, less mobile species are expected to show variation in their spatial genetic structure as well. Based on an intensive pitfall survey, increased anthropogenic alterations of water discharges were shown to cause the loss of stenotopic, xerothermophilic and less mobile riparian arthropods. Next to it, the results of two field experiments indicated that movement decisions of two sympatric wolf spiders (Lycosidae) were guided, particularly, by factors related to their population of origin (side of the river; either genetics or experience). A stenotopic riparian wolf spider, however, relied more on individual information (e.g. visual signals) and showed a higher degree of behavioural plasticity. This might increase the beneficiality of flood-avoiding behaviour. By using Amplified Fragment Length Polymorphism (AFLP) markers, the genetic population structure of the highly stenotopic wolf spider Pardosa agricola (Thorell, 1856) was studied. Nearby populations were less differentiated genetically than populations on different sides of the river, indicating the importance of functional connectivity along the riparian corridor. River restoration and the rehabilitation of the riparian corridor should generate the required heterogeneity at the river bank level, hence increasing the sustainability of dynamic lowland river systems and realizing the conservation of vulnerable riparian arthropods. River management should consider the management of the alluvial hinterland as well to provide suitable refuges during flooding.