Cyclic Nucleotide Phosphodiesterases in Health and Disease

Cyclic Nucleotide Phosphodiesterase Superfamily, J. A. Beavo, M. D. Houslay, and S. H. Francis Phosphodiesterase Isoforms-An Annotated List, G. B. Bolger Section A Specific Phosphodiesterase Families-Regulation, Molecular and Biochemical Characteristics Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases, A. T. Bender PDE2 Structure and Functions, S. E. Martinez Phosphodiesterase 3B: An Important Regulator of Energy Homeostasis, E. Degerman and V. Manganiello Cellular Functions of PDE4 Enzymes, G. B. Bolger, M. Conti, and M. D. Houslay Phosphodiesterase 5: Molecular Characteristics Relating to Structure, Function, and Regulation, S. H. Francis, R. Zoraghi, J. Kotera, H. Ke, E. P. Bessay, M. A. Blount, and J. D. Corbin Photoreceptor Phosphodiesterase (PDE6): A G-Protein-Activated PDE Regulating Visual Excitation in Rod and Cone Photoreceptor Cells, R. H. Cote PDE7, T. Michaeli cAMP-Phosphodiesterase PDE 8 , V. Vasta PDE9, J. Kotera and K. Omori PDE10A: A Striatum Enriched, Dual-Substrate Phosphodiesterase, C. A. Strick, C. J. Schmidt, and F. S. Menniti PDE11, K. Omori and J. Kotera Section B Nonmammalian Phosphodiesterases Protozoal Phosphodiesterases, L.Wentzinger and T. Seebeck Studies of Phosphodiesterase Function Using Fruit Fly Genomics and Transgenics, S. A. Davies and J. P. Day Section C Phosphodiesterases Functional Significance: Gene-Targeted Knockout Strategies Insights into the Physiological Functions of PDE4 from Knockout Mice, S. L. C. Jin, W. Richter, and M. Conti Regulation of cAMP Level by PDE3B-Physiological Implications in Energy Balance and Insulin Secretion, A. Z. Zhao and L. Stenson Holst Section D Compartmentation in Cyclic Nucleotide Signaling Heart Failure, Fibrosis, and Cyclic Nucleotide Metabolism in Cardiac Fibroblasts, S. A. Epperson and L. L. Brunton Role of A-Kinase Anchoring Proteins in the Compartmentation in Cyclic Nucleotide Signaling, O. Witczak, E. M. Aandahl, and K. Tasken Role of Phosphodiesterases in Cyclic Nucleotide Compartmentation in Cardiac Myocytes, A. Abi-Gerges, L. R.V. Castro, F. Rochais, G. Vandecasteele, and R. Fischmeister Section E Phosphodiesterases as Pharmacological Targets in Disease Processes Role of PDEs in Vascular Health and Disease: Endothelial PDEs and Angiogenesis, T. Keravis, A. P. Silva, L. Favot, and C. Lugnier Regulation of PDE Expression in Arteries: Role in Controlling Vascular Cyclic Nucleotide Signaling, D. H. Maurice and D. G. Tilley Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Diseases, C. Yan, D. J. Nagel, and K. Jeon Role of Cyclic Nucleotide Phosphodiesterases in Heart Failure and Hypertension, M. A. Movsesian and C. J. Smith Molecular Determinants in Pulmonary Hypertension: The Role of PDE5, N.J. Pyne, F. Murray, R. Tate, and M.R. MacLean Role of PDE5 in Migraine, C. Kruuse Phosphodiesterase-4 as a Pharmacological Target Mediating Antidepressant and Cognitive Effects on Behavior, H. T. Zhang and J. M. O'Donnell Role of Phosphodiesterases in Apoptosis, A. Lerner, E. Y.Moon, and S. Tiwari Section F Development of Specific Phosphodiesterase Inhibitors as Therapeutic Agents Crystal Structure of Phosphodiesterase Families and the Potential for Rational Drug Design, K. Y. J. Zhang Structure, Catalytic Mechanism, and Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases, H. Ke and H. Wang Bench to Bedside: Multiple Actions of the PDE3 Inhibitor Cilostazol, J. Kambayashi, Y. Shakur, and Y. Liu Reinventing the Wheel: Nonselective Phosphodiesterase Inhibitors for Chronic Inflammatory Diseases, M. A. Giembycz Medicinal Chemistry of PDE4 Inhibitors, J. M. McKenna and G. W. Muller Index