Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Topical Tadalafil Gel in Imiquimod-induced Psoriasiform Skin Inflammation in Mice

To evaluate the possible beneficial effect of tadalafil gel(0.05%) in imiquimod-induced psoriasiform skin inflammation in mice model. forty male BALB/c albino mice with age range of 8-11 weeks and weight ranged 25-40 g; were divided equally into four groups (ten mice / group) after their skin of dorsal back and right ear being shaved for topical application: Group I (normal control) healthy mice without treatment. Group II (Induction group) in which mice received only a daily topical dose of 62.5mg of imiquimod cream (5%) for seven days. The following groups (III and IV), after being received imiquimod cream (5%) as mentioned in induction group, mice were treated for further two weeks with either clobetasol ointment (0.05%) topically once daily (clobetasol group), tadalafil gel (0.05%) topically once daily(tadalafil gel group) Table(1) showed a significant elevation of tissue TNF-α and IL17 with a highly significant increase in IL23 and VEGF levels beside a reduction in the level of TGF-β in induction group as compared to normal control group . Clobetasol group treated displayed a highly significant reduction in TNF-α, IL-17, and VEGF levels beside a reduction in IL-23 and no significant difference in the level of TGF-β when being compared to induction group a highly significant decrease in IL23 level. Beside a no significant decrease in both VEGF and of TGF-β levels in tadalafil gel group in comparison with induction group. The possible effect of anti-inflammatory activity of tadalafil gel on the skin homogenate parameters in imiquimod-induced psoriasiform skin inflammation in mice model.
Identification of a novel haplotype of the Ms locus controlling restoration of male-fertility and its implication in origination of cytoplasmic male-sterility in onion (Allium cepa L.)

ABSTRACT Seeds of F1 hybrid cultivars of onions have been exclusively produced by utilising cytoplasmic male-sterility (CMS). A single locus, Ms, controls restoration of male-fertility of CMS onions. When a molecular marker tagging the AcPMS1 gene, a candidate gene for the Ms locus, was used to genotype diverse breeding lines, an unusual marker genotype showing an intermediate size of PCR product was identified in one breeding line (ORI854). The male-fertility phenotype of ORI854 was all male-sterile. Full-length genomic DNA sequence (16,464 bp) of this novel AcPMS1 allele from ORI854 was more closely related to a recessive AcPMS1 allele than to a dominant allele. However, there were more than 200 polymorphic sequences between this novel allele and the recessive allele, indicating that this novel AcPMS1 allele might not have recently diverged from the recessive allele. Phylogenetic analysis implied that onion male-sterility might have first appeared in a common ancestor before divergence of this novel allele and recessive allele of AcPMS1. Analysis of full-length cDNA sequences of additional 12 genes showing almost perfect linkage disequilibrium with the Ms locus indicated that no recombination might have happened among 13 genes including AcPMS1 in the novel Ms haplotype after divergence from the recessive Ms haplotype.
INTERDISCIPLINARITY AND EDUCATIONAL PRACTICES IN ECO-DEVELOPMENT : ANALYSIS OF THE EXPERIENCE OF THE RIO SAGRADO MICRO-WATERSHED-MORRETES / PR 1

Considering the relationship nature-society, that leads us to the knowledge production process, in which pedagogical practice should be based. The interdisciplinary to respond socio-environmental questions in opposition to the developmental model, should focus in alternatives, reviewing traditional ways of life, capable to induce ecologically based practices, concerned with the sustainability. Thus, there is the perspective of eco-development, aimed at more equitable balance between economic, social and environmental issues. At “Rio Sagrado” watershed, Education’s Zone for Eco-Development, in Morretes (PR) where projects are developed in order to promote the knowledge’s hybridization which should interacting between folk wisdom and scientific knowledge, looking toward to solve social and environmental problems, faced by the local community. Methodologically is an action-research, which had as its main result the environmental changes’ observation, which happened in that territory, where knowledge emerged from the experience and knowhow which could achieve the scientific knowledge.
Construction and Evaluation of Transfer Function of Marginal Soil Temperature on the South Side of Greenhouse under Different Linings

The marginal soil temperature on the south side of a greenhouse remains at low temperatures in winter for long periods, which affects crop growth and land-use efficiency, it is of great significance to grasp the influencing factors of soil temperature change to improve the marginal soil temperature on the south side of the greenhouse. This study was conducted in at typical greenhouse in the cold and arid area of northern China and used the Grey Relational Analysis (GRA) method, the relational degree between the marginal soil temperature on the south side of the greenhouse and environmental factors under different lining structures was analyzed, and established the soil temperature transfer function. The results show that soil temperature had the greatest correlation with the soil humidity and air humidity inside and outside the greenhouse, and the second greatest correlation was the relation with the air temperature inside and outside the greenhouse and the outdoor soil temperature; the lining structure could effectively reduce the relation between soil temperature and humidity inside and outside the greenhouse. Polystyrene extruded board (PEB) had a greater degree of relational reduction than other lining materials in the test. Through verification analysis, the mean absolute error of soil temperature of 5 cm was less than 0.85 °C, the average absolute error of soil temperature at 15 cm was less than 0.57 °C, and the average absolute error of soil temperature at 25 and 55 cm was less than 0.2 °C. In conclusion, the constructed soil temperature transfer function could be used to predict the variation trend of soil temperature, and the PEB material lining structure had good thermal insulation.
Minimal Radiative Neutrino Mass Mechanism for Inverse Seesaw Models

We study a minimal one-loop radiative mechanism for generating small Majorana neutrino masses in inverse seesaw extensions of the Standard Model with two singlet fermions per family. The new feature of this radiative mechanism is that the one-loop induced left-handed neutrino mass matrix is directly proportional to the Majorana mass matrix of the right-handed neutrinos. This is a very economical scenario without necessitating the existence of non-standard scalar or gauge fields.
Assessing the Influence of Reversed Items and Force-Choice on the Work and Meaning Inventory [Evaluación de la influencia de los ítems invertidos y de elección forzosa en el Inventario de trabajo significativo]

Abstract Response biases are issues in inventories in positive organizational psychology. The study aims to control the response bias in the assessment of meaning of work through two methods: reversed key items and forced-choice format. The sample consisted of 351 professionals; women constituted 60.0 % of the sample. The participants answered two versions of the instrument for meaning of work: Likert-type items and forced-choice. For both versions, the unifactorial model was the most appropriate for the data available. The results indicate that the random intercepts model fit the Likert data (CFI = .92), as well as the forced-choice model (CFI = .97). Besides, the latent dimension of the forced-choice version did not correlate with acquiescence index ( r .05), and approximately 20 % of the variance of the items might be due to the method (Likert or forced-choice). The present study illustrates the importance of response bias control in self-report instruments. Resumen Los sesgos de respuesta son problemas en los inventarios de la psicologia organizacional positiva. El estudio tiene como objetivo controlar el sesgo de respuesta en la eva­luacion del trabajo significativo a traves de dos metodos: items clave invertidos y formato de eleccion forzosa. La muestra estuvo formada por 351 profesionales; las muje­res constituyeron el 60.0 % de la muestra. Los participan­tes respondieron dos versiones del instrumento de signifi­cado del trabajo: items tipo Likert y eleccion forzosa. Para ambas versiones, el modelo unifactorial fue el mas apro­piado para los datos disponibles. Los resultados indican que el modelo de intersecciones aleatorias se ajusta a los datos Likert (CFI = .92), asi como al modelo de eleccion forzada (CFI = .97). Ademas, la dimension latente de la version de eleccion forzada no se correlaciono con el in­dice de aquiescencia ( r .05), y aproximada­mente el 20 % de la varianza de los items podria deberse al metodo (Likert o forzado). eleccion). El presente estu­dio ilustra la importancia del control del sesgo de res­puesta en los instrumentos de autoinforme.
Syntheses, crystal structures, and IR spectra of isonicotinamide-isonicotinamidium bis(isonicotinamide)-tetrakis(isothiocyanato)ferrate(III) and isonicotinamidium chloride

Reaction of iron(III) thiocyanate with isonicotinamide (inia) in ethanol leads to formation of a dark red, air stabile crystalline iron(III) compound of composition [iniaH·inia][Fe(inia)2(NCS-N)4]. Single-crystal X-ray diffraction analysis shows the triclinic P–1 space group with unit cell parameters: a = 8.2440(4) Å, b = 9.5540(3) Å, c = 11.2590(5) Å, α = 93.945(4)°, β = 95.554(4)°, γ = 96.285(3)°, and Z = 1. The iron compound contains [iniaH·inia]+ cations and [Fe(inia)2(NCS-N)4]– anions, which are held together by ionic interactions and hydrogen bonding. The Fe(III) is octahedrally coordinated by six nitrogens, four from NCS– in the equatorial plane and two from inia occupying axial positions. The [iniaH]Cl has been formed by reaction of inia with hydrochloric acid. [iniaH]Cl crystallized in the monoclinic C2/c space group with unit cell parameters: a = 25.156(5) Å, b = 5.095(1) Å, c = 12.747(3) Å, and Z = 8. Both compounds have also been characterized by elemental analyses and infrared spectroscopy. Structural and infrared spectral data are compared with data of similar compounds in the literature. Graphical Abstract
Measuring social support perceived by inclusive education teachers in China

ABSTRACT Social support perceived by inclusive education teachers is seldom empirically investigated, and there are few tools to measure it. This research aims to develop a valid instrument to investigate inclusive education teachers’ social support and to determine the current situation of such support in China. A total of 216 and 367 valid questionnaires from teachers in elementary and junior high inclusive education schools were collected in study 1 and study 2, respectively. The findings indicated that (1) Chinese inclusive education teachers’ social support was represented by a four-factor model with high reliability and validity that included professional, emotional, administrative and material support; (2) teachers received mostly emotional support, followed by administrative support, material support, and then professional support; and (3) demographic variables such as age, length of service, academic qualification, training time, and establishment of a school resource room had significant influences on teachers’ perceived social support. The study contributes to developing a conceptual framework and measurement instrument for Chinese inclusive education teachers’ social support. It provides practical implications for the improvement of current Chinese teacher education programmes and the development of high-quality inclusive education.
The management of the Eurozone in crisis times: Actors, institutions and the case of bailout packages

The adjustment to the financial crisis was particularly brutal for Eurozone countries targeted by private bondholders. Financial assistance through the newly created Eurozone governance system was conditional on the implementation of austerity measures and the introduction of structural reforms in industrial relations (decentralization of collective bargaining and liberalization of employment protection). Our analysis focuses on the formation process and the structural features of Eurozone supranational institutions. Building from the insights of actor-centred institutionalism, we illustrate the importance of coalitions among some, but not all, important actors based on the overlapping of their non-monolithic preferences in the process of institutional innovation. The structural features of Eurozone institutions curtailed member states’ ability to effectively resist the imposition of internal devaluation policies. A contested outcome, these institutional features were secured by a specific coalition of important actors – most notably, the German government and the European Central Bank – based on their overlapping interests around internal devaluation policies.
Exploring optimal pharmacotherapy after bariatric surgery: where two worlds meet

In dit proefschrift staan diverse aspecten van de optimale toepassing van geneesmiddelen na overgewichtschirurgie (bariatrische chirurgie) centraal. Door de veranderingen in het maagdarmkanaal na een operatie, kunnen de effectiviteit en de veiligheid van geneesmiddelen veranderen. Over de effectieve en veilige toepassing van geneesmiddelen na een bariatrische ingreep is nog vrij weinig bekend. Specifiek richten de onderzoeken in het proefschrift zich op de volgende onderwerpen. Metoprolol is een geneesmiddel dat veel wordt toegepast bij hoge bloeddruk en hart- en vaatziekten. Een onderzoek met vrouwelijke patienten toonde aan, dat de biologische beschikbaarheid van metoprolol tabletten kan worden beinvloed door een bepaald type bariatrische ingreep (Roux-en Y gastric bypass). Patienten die na deze ingreep metoprolol gebruiken, dienen nauwgezet in de gaten te worden gehouden met mogelijk aanpassing van de dosering. Ondanks richtlijnen om het gebruik van NSAID’s (een soort pijnstillers) na de operatie te vermijden is het gebruik bij patienten die bariatrische chirurgie hebben ondergaan, aanzienlijk. Een interventiestudie gericht op het verminderen van het gebruik van NSAID’s was niet succesvol. Een risicosituatie blijft daarmee bestaan en vraagt vervolgonderzoek. Op basis van onderzoek met een uitgebreide database van Britse huisartsen hebben wij aangetoond, dat bariatrische chirurgie de kans op remissie van type 2 diabetes mellitus sterk verhoogt. Een bariatrische operatie, met name een gastric bypass of sleeve operatie, kan als nieuwe behandeling voor type 2 diabetes mellitus worden overwogen. Kennis van de soorten bariatrische operaties en hun mogelijke invloed op het gebruik en de biologische beschikbaarheid van geneesmiddelen, is een voorwaarde voor optimale medicatiebewaking.
Effects of CEO Overseas Experience on Corporate Social Responsibility: Evidence from Chinese Manufacturing Listed Companies

With increasing economic globalization, CEOs with overseas study or work experience play a crucial role in corporate strategic decision making, especially in emerging economies. Using Chinese manufacturing companies publicly listed on the Shanghai or Shenzhen Stock Exchanges, we explore the influence of CEO overseas experience on corporate social responsibility (CSR), based on the upper echelons theory and behavioral theory of the firm. We find that CEOs with overseas experience have a stronger CSR thinking concept and are more inclined to fulfill CSR than CEOs without overseas experience. We also analyze the effects of the organization’s external environment (market competition intensity) and internal resources (organizational slack resources) on this relationship, and find that all of these factors can strengthen the relationship. We find that the effect of CEO overseas study experience is stronger than that of overseas work experience; CEOs with overseas experience from developed countries such as Europe and the United States have a stronger effect on CSR; CEO overseas experience leads to better performance in state-owned enterprises; but when the CEO is also the chairman of the board, the effect of CEO overseas experience on CSR is weaker; female CEOs’ overseas experience has a stronger positive effect on CSR than male CEOs’; and the effect of CEO overseas experience on CSR is greater when the CEO is highly educated.
The Effect of Saliva Officinalis L (Sage Tea) on Biochemical and Pathological Changes Improvment in Adult Male Rats Induced by a High Fat Diet

In order to investigate the physiological-protective effect of sage tea (Salvia officinalis L.) through its role in lipid profile regulation in male laboratory rats, current research has been carried out. In this study, sixty albino male laboratory rats (100-160 g) and older rats (4-7 weeks) were used. Based on the experimental nature of the study, animals were randomly divided into three main groups (six rats per group), a control group was considered to be the first group to be fed on a standard diet, and a 28-day atherogenic diet group was considered to be the second group to be fed on a standard diet (A). And the other group (B) (including subgroups) were previously fed 28 days on an atherogenic diet; oral administration was conducted as follows: the third group (B) included subgroups (B1) and (B2) administered 14 and 28 days of sage tea (S. officinalis) (0.086 mg/kg body weight) respectively. The measurement of changes in body weight and liver function enzymes (ALT, AST and ALP) and liver organ histopathology trials was done.In the results of the study, a significant increase (p ≤ 0.05) in the body weight of rats fed a high-fat diet (HFD) (group A) was seen compared to the control group fed a standard diet. Although body weights in The other groups were reduced in the sage tea treated group ( group B), the findings of the test of liver function enzymes in animals fed on an atherogenic diet (group A) revealed a substantial increase (p ≤ 0.05) in the level of the ALT enzyme associated with the non-changeable rate of the enzymes (AST) and (ALP), although they revealed a mild elevation relative to the control group. a slight decrease in all serum liver enzyme levels without significant difference in all experimental treatments (groups B) for both periods of 14 and 28 days. In relation to group (A), the increase and stabilization of liver enzyme levels at normal levels relative to control group values was reported, especially in the long term (28 days). In addition, histopathological examinations in the present sample showed histological changes in the liver organ compared with the control group due to feeding on a high fat diet (group A). These changes include blood vessels congestion, fat accumulation of liver connective tissue. In animals treated with sage tea (group A), a microscopic analysis of the liver showed typical histological characteristics with less fat deposition and minimal changes in histo-structural characteristics relative to the atherogenic diet group of animals. This indicates that improvement has been associated with long-term therapy (28 days). In conclusion, in reducing the functional performance and normal histological characteristics of long-term treatment-related liver and kidney organs, sage tea administration has an important synergistic protective role (28 days).
Cosmological bounds on sub-MeV mass axions

Axions with mass m{sub a} ∼> 0.7 eV are excluded by cosmological precision data because they provide too much hot dark matter. While for m{sub a} ∼> 20 eV the a → 2γ lifetime drops below the age of the universe, we show that the cosmological exclusion range can be extended to 0.7eV ∼< m{sub a} ∼< 300 keV, primarily by the cosmic deuterium abundance: axion decays would strongly modify the baryon-to-photon ratio at BBN relative to the one at CMB decoupling. Additional arguments include neutrino dilution relative to photons by axion decays and spectral CMB distortions. Our new cosmological constraints complement stellar-evolution and laboratory bounds.
Boundedness for fractional Hardy-type operator on Herz-Morrey spaces with variable exponent

In this paper, the fractional Hardy-type operator of variable order $\beta(x)$ is shown to be bounded from the Herz-Morrey spaces $M\dot{K}_{p_{_{1}},q_{_{1}}(\cdot)}^{\alpha,\lambda}(\mathbb{R}^{n})$ with variable exponent $q_{1}(x)$ into the weighted space $M\dot{K}_{p_{_{2}},q_{_{2}}(\cdot)}^{\alpha,\lambda}(\mathbb{R}^{n},\omega)$, where $\omega=(1+|x|)^{-\gamma(x)}$ with some $\gamma(x)>0$ and $ 1/q_{_{1}}(x)-1/q_{_{2}}(x)=\beta(x)/n$ when $q_{_{1}}(x)$ is not necessarily constant at infinity. It is assumed that the exponent $q_{_{1}}(x)$ satisfies the logarithmic continuity condition both locally and at infinity that $1< q_{1}(\infty)\le q_{1}(x)\le( q_{1})_{+}<\infty~(x\in \mathbb{R}^{n})$.
A Review of Piezoelectric Material-Based Structural Control and Health Monitoring Techniques for Engineering Structures: Challenges and Opportunities

With the breadth of applications and analysis performed over the last few decades, it would not be an exaggeration to call piezoelectric materials “the top of the crop” of smart materials. Piezoelectric materials have emerged as the most researched materials for practical applications among the numerous smart materials. They owe it to a few main reasons, including low cost, high bandwidth of service, availability in a variety of formats, and ease of handling and execution. Several authors have used piezoelectric materials as sensors and actuators to effectively control structural vibrations, noise, and active control, as well as for structural health monitoring, over the last three decades. These studies cover a wide range of engineering disciplines, from vast space systems to aerospace, automotive, civil, and biomedical engineering. Therefore, in this review, a study has been reported on piezoelectric materials and their advantages in engineering fields with fundamental modeling and applications. Next, the new approaches and hypotheses suggested by different scholars are also explored for control/repair methods and the structural health monitoring of engineering structures. Lastly, the challenges and opportunities has been discussed based on the exhaustive literature studies for future work. As a result, this review can serve as a guideline for the researchers who want to use piezoelectric materials for engineering structures.
Earthquake hazard and civic capital

We examine the empirical relationship between the exposure to earthquake hazard and civic capital in Italian municipalities. Drawing on the Italian National Institute of Geophysics and Volcanology, we find that earthquake hazard increases civic capital. We decompose the effect of earthquake hazard variation along four dimensions – frequency, space, magnitude, and timing – and observe that the effect is mostly explained by high-magnitude seismic events in the past. Our results are in line with the intuition that cooperative social norms build over a very long time span.