Miracle-dz/UniFAR-FTUs huggingface dataset:
New Evidence for the Complex Structure of the Red Giant Branch in ω Centauri

We report on the complex structure of the red giant branch (RGB) of ω Centauri, based on a new wide-field and wide-color baseline B and I photometry. Our color-magnitude diagram (CMD) shows the presence of multiple populations along this branch; in particular, we discovered an anomalous branch (RGB-a), which appears to be well separated from the bulk of the RGB stars. On the basis of our CMD and from the previous literature, we conclude that (1) these stars, clearly identified as a separate population in our CMD, represent the extreme metal-rich extension ([Ca/H] > -0.3) of the stellar content of ω Cen and show anomalous abundances of s-process elements (as Ba and Zr) as well; (2) they are physical members of the ω Cen system; (3) they comprise ~5% of the stars of the whole system; and (4) this component and the metal intermediate one (-0.4 > [Ca/H] > -1) have been found to share the same spatial distribution, both of them differing significantly from the most metal-poor one ([Ca/H] < -1). This last piece evidence supports the hypothesis that metal-rich components could belong to an independent (proto? ) stellar system captured in the past by ω Cen.
(2017). The Dynamic Black-Litterman Approach to Asset Allocation. European Journal of Operational Research, 259(3), 1085–1096.

We generalise the Black-Litterman (BL) portfolio management framework to incorporate time-variation in the conditional distribution of returns in the asset allocation process. We evaluate the performance of the dynamic BL model using both standard performance ratios as well as other measures that are designed to capture tail risk in the presence of non-normally distributed asset returns. We find that the dynamic BL model outperforms a range of different benchmarks. Moreover, we show that the choice of volatility model has a considerable impact on the performance of the dynamic BL model.
EVALUATION OF EFFECTS OF DIFFERENT COMBINATIONS OF SELECTED SEDATIVES ON THE HEMATOLOGICAL PROFILE OF STANDING SEDATED HORSES

Alpha-2 agonists induce changes in the hemogram in equines. The aim of the present study was to examine the magnitude of changes in the selected blood parameters produced by various α - 2- agonists combinations. For this purpose, 25 horses were the animals of study during different clinical examinations and minor surgical interventions in standing sedation. Blood samples were collected from the jugular venipuncture of horses before sedation, 15 mins. , 30 mins. , and 60 mins. , after drug administration.The blood parameters evaluated were Packed cell volume (PCV), Haemoglobin concentration (Hb), Red blood cells (RBC), Total leukocytes count (TLC), and Differential leucocytes count (DLC) (neutrophils, eosinophils and monocytes). Analysis of variance (1-way ANOVA) were performed with p<0.05. Hb, PCV, TLC and DLC declined gradually in all groups post drug administration. Pre-sedation values for all parameters were significantly different from post-sedation values at 15, 30, and 60 minutes. There was no significant effect of drug groups on Hb, neutrophil and eosinophil values. Group A (Acepromazine + Detomidine combination) produced significant decrease in PCV values compared with group C (Acepromazine + Ketamine) and group D (Acepromazine + Detomidine + Ketamine). RBC values of group B (Detomidine + Ketamine) showed significant difference compared with group C, D, & E (Acepromazine + Xylazine + Ketamine). TLC and monocyte values of group B were significantly different from D & E groups. It was concluded that drug combination with acepromazine, detomidine, xylazine and ketamine cause minimal hematological side effects. Therefore, these drugs could be safely used for inducing standing sedation in horses.
Changes in the Hematology Parameters of Freshwater Fish Channa striatus Exposed to the Pesticide of Propargite

In the present study was sublethal concentrations of propargite pesticide administered to freshwater fish C. striatus for 96 hours propargite exposure is 0.34 parts per million (ppm) based on the period of (0.034ppm), (1.02ppm), 15 and 30 days about significantly ( P > 0.05) in hematological parameters alterations was recorded. The hematological analysis showed significant ( P > 0.05) reduction in red blood cell count, hemoglobin value, packed cell volume, mean corpuscular hemoglobin (MCH), MCH concentration, and mean corpuscular volume. The parameters such as total white blood cells increased when induced toxic content. The present study indicated marked changes in the blood of C. striatus after exposure to propargite pesticide.
THE ROLE OF PARA-AMINOSALICYLIC ACID (PAS) AND N-(2-HYDROXYETHYL) ETHYLENEDIAMINE TRIACETIC ACID (HEDTA) IN ALLEVIATING THE OXIDATIVE CHANGES INDUCED BY MANGANESE NEUROTOXICITY IN ALBINO RATS

This study was conducted to explore the capability of PAS (Para- aminosalicylic acid) and HEDTA [N-(2-hydroxyethyl) ethylenediamine triacetic acid] either alone or in combination in reducing some oxidative changes in different brain regions (cerebral cortex, cerebellum and medulla oblongata) in rats exposed to manganese. Seventy five male weanling rats (PND 21) were divided into two groups, group (A) served as (-ve) control group (C1) and group (B) received manganese chloride tetrahydrate (MnCl 2 . 4 H 2 O) via drinking water for 60 days in a concentration of 5 mg MnCl 2 / ml of H 2 O. Twenty four hours after cessation of Mn exposure, group B was divided into 5 subgroups. Rats of group B1 were killed directly after cessation of Mn exposure and served as +ve control group. Rats of group B2 received saline solution 0.9% intraperitoneally (i/p) for 4 weeks served as withdrawal group. Rats of group B3 received 200 mg PAS / Kg b.w. S/C daily for 5 days/week for 4 weeks, group B4 rats were received 50 mg HEDTA / Kg b.w. i/p daily for 5 days/week for 4 weeks and group B5 received mixture of both PAS and HEDTA in the same manner and concentration as in group B3 and B4. Animal groups treated with each chelating agent separately, recovered the neurotoxicity and oxidative stress induced by Mn. 4H 2 O and that indicated by significant improvement in superoxide dismutase (SOD), catalase, AChE and glutathione peroxidase activity as well as marked decrease in TBARS and nitric oxide production as compared to Mn treated group. Withdrawal group showed no improvement in most of the previous parameters which may be attributed to the irreversible damage of Mn to the brain tissues. __________________________________________________________________________________________
Performance Evaluation of Two Indoor Mapping Systems: Low-Cost UWB-Aided Photogrammetry and Backpack Laser Scanning

During the past dozen years, several mobile mapping systems based on the use of imaging and positioning sensors mounted on terrestrial (and aerial) vehicles have been developed. Recently, systems characterized by an increased portability have been proposed in order to enable mobile mapping in environments that are difficult to access for vehicles, in particular for indoor environments. In this work the performance of a low-cost mobile mapping system is compared with that of: (i) a state-of-the-art terrestrial laser scanning (TLS), considered as the control; (ii) a mobile mapping backpack system (Leica Pegasus), which can be considered as the state-of-the-art of commercial mobile mapping backpack systems. The aim of this paper is two-fold: first, assessing the reconstruction accuracy of the proposed low-cost mobile mapping system, based on photogrammetry and ultra-wide band (UWB) for relative positioning (and a GNSS receiver if georeferencing is needed), with respect to a TLS survey in an indoor environment, where the global navigation satellite system (GNSS) signal is not available; second, comparing such performance with that obtained with the Leica backpack. Both mobile mapping systems are designed to work without any control point, to enable an easy and quick survey (e.g., few minutes) and to be easily portable (relatively low weight and small size). The case study deals with the 3D reconstruction of a medieval bastion in Padua, Italy. Reconstruction using the Leica Pegasus backpack allowed obtaining a smaller absolute error with respect to the UWB-based photogrammetric system. In georeferenced coordinates, the root mean square (RMS) error was respectively 16.1 cm and 50.3 cm; relative error in local coordinates was more similar, respectively 8.2 cm and 6.1 cm. Given the much lower cost (approximately $6k), the proposed photogrammetric-based system can be an interesting alternative when decimetric reconstruction accuracy in georeferenced coordinates is sufficient.
Identification of a novel endoplasmic export motif within the eighth domain of the human

reticulum alpha-helical (alpha-H8) receptor Abstract The human prostacyclin receptor (hIP) undergoes agonist-dependent trafficking involving a direct interaction with Rab11a GTPase. The region of interaction was localised to a 14 residue Rab11a binding domain (RBD) within the proximal carboxyl-terminal (C)-tail domain of the hIP, consisting of Val 299 – Val 307 within the eighth helical domain ( α -H8) adjacent to the palmitoylated residues at Cys 308 – Cys 311 . However, the factors determining the anterograde transport of the newly synthesised hIP from the endoplasmic reticulum (ER) to the plasma membrane (PM) have not been identified. The aim of the current study was to identify the major ER export motif(s) within the hIP initially by investigating the role of Lys residues in its maturation and processing. Through site-directed and Ala-scanning mutational studies in combination with analyses of protein expression and maturation, functional analyses of ligand binding, agonist-induced intracellular signalling and confocal image analyses, it was determined that Lys 297 , Arg 302 and Lys 304 located within α -H8 represent the critical determinants of a novel ER export motif of the hIP. Furthermore, while substitution of those critical residues significantly impaired maturation and processing of the hIP, replacement of the positively charged Lys with Arg residues, and vice versa , was functionally permissible. Hence, this study has identified a novel 8 residue ER export motif within the functionally important α -H8 of the hIP. This ER export motif, defined by ‘K/R(X) 4 K/R(X)K/R’, has a strict requirement for positively charged, basic Lys/Arg residues at the 1 st , 6 th and 8 th positions and appears to be evolutionarily conserved within IP sequences from mouse to man. HA-tagged Fluor® System C-tail, carboxyl-terminal tail domain. C . I-TASSER three-dimensional structural analysis of the hIP predicts that it contains 7 TM, typical of its GPCR structure, and that K 297 – V 307 (insets; plane and cross-sectional views), within its proximal C-tail domain, is organised into the eighth α -helical domain ( α -H8). Data herein establish that K 297 , R 302 and K 304 , within α -H8, form the essential residues of a novel 8 amino acid ER export motif, defined by K/R(X) 4 K/R(X)K/R, within the hIP, where X represents any amino acid.
Pulmonary Blood Volume Measured by Dual-Energy Computed Tomography Can Help Distinguish Patients With Pulmonary Hypertension

Purpose To evaluate the correlation between whole lung enhancement (WLE) and pulmonary blood volume (PBV) obtained through dual energy computed tomography pulmonary angiography (DECTPA) and echocardiography-derived systolic pulmonary arterial pressure (SPAP). Methods Sixty-eight patients who underwent DECTPA were enrolled in the study after giving informed consent. A transthoracic echocardiography was performed for all the subjects within 48 h of their DECTPA study to measure SPAP. The correlation of the two DECTPA-derived parameters, WLE and PBV, with SPAP was assessed. In addition, the predictive strength of these parameters was compared with that of traditional computed tomography (CT) signs of pulmonary hypertension (PH). Results The SPAP value showed a moderate correlation with main pulmonary artery (MPA) diameter (r = 0.48, P < 0.001), while having a weak correlation with WLE (r = −0.33, P = 0.007), PBV (r = −0.31, P = 0.01) and MPA/ascending aorta (MPA/AA) ratio (r = 0.26, P = 0.03). On regression analysis, MPA diameter (B ± SE: 1.8 ± 0.6, P = 0.004) and WLE (B ± SE: −0.5 ± 0.3, P = 0.042) had significant association with SPAP. In addition, SPAP ≥30 mmHg was related to the right to left ventricular diameter (RV/LV) ratio [OR (CI 95%): 24.39 (1.3–573.2), P = 0.04] and reversely associated with PBV [OR (CI 95%): 0.96 (0.93–0.98), P = 0.005]. Acquired cutoff value of 83% for PBV showed sensitivity and specificity of 73% to identify SPAP ≥30 mmHg [AUC (CI 95%):0.727 (0.588–0.866), P = 0.008]. Conclusions Automated postprocessing calculation of iodine distribution analysis by DECTPA could be considered as an adjunctive tool to investigate for PH.
Feasibility of Same-Day Discharge After Appendectomy in Pediatric Patients: A Systematic Review and Meta-Analysis

Background To compare the readmission rate, rate of urgent/unplanned visits to emergency, complication rate along with cost of health care among children and adolescents who were discharged the same day following a laparoscopic appendectomy and those who were not discharged on the same day. Methods A systematic search was performed in the PubMed, Embase, and Scopus databases. Randomized controlled trials and studies, observational in design, were considered for inclusion. The included studies were conducted in children and adolescents with uncomplicated appendicitis undergoing laparoscopic appendectomy and compared outcomes of interest between patients that were discharged the same day (SDD group) following the operation and patients that were discharged within 2 days post-operatively (non-SSD group). Statistical analysis was performed using STATA software. Effect sizes were reported as pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence intervals. Results A total of 13 studies with 32,021 children and adolescents were included. There was no significant difference in the risks of unplanned visit to the emergency department (OR 1.07, 95% CI: 0.78, 1.47), readmission (OR 0.83, 95% CI: 0.66, 1.05), reoperation/re-intervention (OR 1.73, 95% CI: 0.19, 16.2) and complications (OR 0.84, 95% CI: 0.67, 1.06) in both groups of patients. Patients in the SDD group had slightly lower risk of wound infection/complication (OR 0.74, 95% CI: 0.57, 0.96) compared to patients in the non-SDD group. Those with SDD had to incur comparatively lesser hospital expense (in USD) compared to those with no SDD (WMD −2587.4, 95% CI: −4628.3, −546.6). Conclusion In children and adolescents with uncomplicated acute appendicitis undergoing laparoscopic appendectomy, same-day discharge is not associated with increased readmission risk, unplanned visits to emergency, and complications. Further, SDD is associated with lower cost of hospital care. Adoption of SDD in this subset of children and adolescents may be encouraged. Systematic Review Registration [www.crd. york.ac. uk/prospero], identifier [CRD420 22320539].
Financial Crisis in Management Stress: From the Perspective of Crisis Anxiety of Others

The crisis anxiety of others is a phenomenon that goes hand in hand with the spread of the occupational health pandemic. It is becoming increasingly important to better understand its emergence process, especially in the era of greater uncertainty. This study aims to examine the impact of the external financial crisis on managerial stress among financial employees. The sample consists of 347 senior managers and financial employees from companies in China. The empirical analysis shows that external financial crises have significant effects on anxiety levels, especially external corporate crisis, debt crisis and growth crisis both have mediating effect on the relationship between anxiety level and pressure management and the relationship between external financial crisis and pressure management. This study explores the rules for the emergence of anxiety among corporate managers and expands the scope of environmental factors that need to be discussed in the study of corporate financial management. This study provides theoretical implications for the psychological study of Financial Management and practical implications for corporate financial management.
Spatial and Temporal Dynamics of Aedes albopictus Populations in Rural and Agricultural Areas in Chania, Greece, After Its Invasion

Aedes albopictus, also known as the Asian tiger mosquito, is an aggressive invasive mosquito species that transmits parasites that cause several major human diseases such as dengue, Chikungunya, and Zika. Its recent establishment in many European countries and the reported autochthonous cases of Aedes-transmitted arboviral diseases highlight the importance of effective surveillance programs to plan and implement efficient mosquito-control interventions. Aedes albopictus invaded the Greek island of Crete in 2014 and rapidly spread throughout; however, there are no comprehensive population-related data yet available. Our study focused on spatial and temporal dynamics of Ae. albopictus populations in rural and agricultural areas in Chania (western part of the Crete Island). An oviposition surveillance network, consisting of 51 ovitraps, was established in 2017 and systematically inspected for 2 years. Thirty ovitraps were established in rural areas and 21 in the surrounding agricultural areas. Eggs were collected weekly and transferred to the laboratory for counting and assessment of hatching rates. The spatial and temporal egg distribution was assessed by using geographical information systems and spatial statistical analysis tools. Kernel density and hot spot analysis were employed to identify clusters of high populations of eggs. Oviposition activity (eggs in traps) was recorded during April–May and December (of both years), while the maximum egg-laying rates were observed during September–October. The proportion of traps with eggs was similar between rural and agricultural areas, while the higher number of eggs was recorded in rural compared to agricultural areas during 2017. Egg hatch rates were high (>90%) until the end of September. The proportion of diapausing non-hatched eggs rapidly increased at the end of November. All hatched larvae were identified as Ae. Albopictus, indicating a negative effect of the invasion on the population of the local species Ae. cretinus. This was a systematic attempt to monitor the seasonal and spatial patterns of the Asian tiger mosquito in the island of Crete, the southernmost area of Europe, and a study in Europe that assessed temporal and spatial dynamics of Ae. albopictus soon after its invasion and establishment in an area.
Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these proteases. However, the intrinsic, high electrophilicity of the aldehyde group is associated with safety concerns and metabolic instability, limiting the use of aldehyde inhibitors as drugs. We have developed a novel class of compounds, self-masked aldehyde inhibitors (SMAIs) which are based on the dipeptide aldehyde inhibitor (Cbz-Phe-Phe-CHO, 1), for which the P1 Phe group contains a 1′-hydroxy group, effectively, an o-tyrosinyl aldehyde (Cbz-Phe-o-Tyr-CHO, 2; (Li et al. (2021) J. Med. Chem. 64, 11,267–11,287)). Compound 2 and other SMAIs exist in aqueous mixtures as stable δ-lactols, and apparent catalysis by the cysteine protease cruzain, the major cysteine protease of Trypanosoma cruzi, results in the opening of the lactol ring to afford the aldehydes which then form reversible thiohemiacetals with the enzyme. These SMAIs are also potent, time-dependent inhibitors of human cathepsin L (K i = 11–60 nM), an enzyme which shares 36% amino acid identity with cruzain. As inactivators of cathepsin L have recently been shown to be potent anti-SARS-CoV-2 agents in infected mammalian cells (Mellott et al. (2021) ACS Chem. Biol. 16, 642–650), we evaluated SMAIs in VeroE6 and A549/ACE2 cells infected with SARS-CoV-2. These SMAIs demonstrated potent anti-SARS-CoV-2 activity with values of EC50 = 2–8 μM. We also synthesized pro-drug forms of the SMAIs in which the hydroxyl groups of the lactols were O-acylated. Such pro-drug SMAIs resulted in significantly enhanced anti-SARS-CoV-2 activity (EC50 = 0.3–0.6 μM), demonstrating that the O-acylated-SMAIs afforded a level of stability within infected cells, and are likely converted to SMAIs by the action of cellular esterases. Lastly, we prepared and characterized an SMAI in which the sidechain adjacent to the terminal aldehyde is a 2-pyridonyl-alanine group, a mimic of both phenylalanine and glutamine. This compound (9) inhibited both cathepsin L and 3CL protease at low nanomolar concentrations, and also exerted anti-CoV-2 activity in an infected human cell line.
Eye-Tracking in Interpreting Studies: A Review of Four Decades of Empirical Studies

It has been four decades since eye-tracking was first used in interpreting studies, and recent years has witnessed a growing interest in the application of this method, which holds great potential for offering a look into the “black box” of interpreting processing. However, little attention has been paid to comprehensively illustrating what has been done, what can be done, and what needs to be done with this method in this discipline. With this in view, this paper sets out to understand contributions of previous studies—key themes discussed, eye-tracking measures used, their limitations and implications, and future directions. To this end, we conduct a review of a total of 26 empirical papers from peer-reviewed journals within a time span of 4 decades ranging from 1981 to 2021. This study, as the first attempt of its kind at a comprehensive review on using eye-tracking in interpreting studies, should have implications for researchers, educators, and practitioners.