Miracle-dz/UniFAR-FTUs huggingface dataset:
Star Formation in the Orion Nebula Cluster

We study the record of star formation activity within the dense cluster associated with the Orion Nebula. The bolometric luminosity function of 900 visible members is well matched by a simplified theoretical model for cluster formation. This model assumes that stars are produced at a constant rate and distributed according to the field-star initial mass function. Our best-fit age for the system, within this framework, is 2 × 106 yr. To undertake a more detailed analysis, we present a new set of theoretical pre-main-sequence tracks. These cover all masses from 0.1 to 6.0 M☉, and start from a realistic stellar birthline. The tracks end along a zero-age main-sequence that is in excellent agreement with the empirical one. As a further aid to cluster studies, we offer an heuristic procedure for the correction of pre-main-sequence luminosities and ages to account for the effects of unresolved binary companions. The Orion Nebula stars fall neatly between our birthline and zero-age main-sequence in the H-R diagram. All those more massive than about 8 M☉ lie close to the main sequence, as also predicted by theory. After accounting for the finite sensitivity of the underlying observations, we confirm that the population between 0.4 and 6.0 M☉ roughly follows a standard initial mass function. We see no evidence for a turnover at lower masses. We next use our tracks to compile stellar ages, also between 0.4 and 6.0 M☉. Our age histogram reveals that star formation began at a low level some 107 yr ago and has gradually accelerated to the present epoch. The period of most active formation is indeed confined to a few × 106 yr, and has recently ended with gas dispersal from the Trapezium. We argue that the acceleration in stellar births, which extends over a wide range in mass, reflects the gravitational contraction of the parent cloud spawning this cluster.
Experimental analysis of the effective components of problem‐based learning

Problem-based learning (PBL) is widely endorsed as a desirable learning method, particularly in science. Especially in light of the method's heavy demand on resources, evidence-based practice is called for. Rigorous studies of the method's effectiveness, however, are scarce. In Study 1, college students enrolled in an elementary physics course participated in 7 hours of instruction on two concepts, one (electromagnetic field) via a PBL method and the other (gravitational field) via a lecture/discussion method. A comparison class enrolled in the same course with the same instructor underwent the identical experience except that matching of concept and method was reversed. Multiple assessments over time showed superior mastery of the concept learned via PBL for both groups. In Study 2, using a subtractive method, we further investigated the role of specific components of the PBL method by comparing a group who worked individually using a PBL method to one who participated in the typical collaborative form of PBL. Rather than the social component typically associated with PBL, the effective component of the method appears to be the focus on engagement with a problem. © 2010 Wiley Periodicals, Inc. Sci Ed95: 57–86, 2010.
Persons with Patellar Tendinopathy Exhibit Greater Patellar Tendon Stress during a Single-Leg Landing Task

ABSTRACT Purpose This study aimed to compare peak maximum principal stress in the patellar tendon between persons with and without patellar tendinopathy during a simulated single-leg landing task. A secondary purpose was to determine the biomechanical predictor(s) of peak maximum principal stress in the patellar tendon. Methods Using finite element (FE) modeling, patellar tendon stress profiles of 28 individuals (14 with patellar tendinopathy and 14 pain-free controls) were created at the time of the peak knee extensor moment during single-leg landing. Input parameters to the FE model included subject-specific knee joint geometry and kinematics, and quadriceps muscle forces. Independent t-tests were used to compare the peak maximum principal stress in the patellar tendon and biomechanical variables used as input variables to the FE model (knee flexion, knee rotation in the frontal and transverse planes and the peak knee extensor moment) between groups. A stepwise regression model was used to determine the biomechanical predictor(s) of peak maximum principal stress in the patellar tendon for both groups combined. Results Compared with the control group, persons with patellar tendinopathy exhibited greater peak maximum principal stress in the patellar tendon (77.4 ± 25.0 vs 60.6 ± 13.6 MPa, P = 0.04) and greater tibiofemoral joint internal rotation (4.6° ± 4.6° vs 1.1° ± 4.2°, P = 0.04). Transverse plane rotation of the tibiofemoral joint was the best predictor of peak maximum principal stress in the patellar tendon (r = 0.51, P = 0.01). Conclusions Persons with patellar tendinopathy exhibit greater peak patellar tendon stress compared with pain-free individuals during single-leg landing. The magnitude of peak patellar tendon stress seems to be influenced by the amount of tibiofemoral rotation in the transverse plane.
Association of Uncontrolled Hypertension or Diabetes Mellitus With Major Adverse Cardiovascular Events and Mortality in South Korea: Population-Based Cohort Study

Background Managing hypertension (HT) and diabetes mellitus (DM) is crucial to preventing cardiovascular diseases. Few studies have investigated the incidence and risk of cardiovascular diseases or mortality in uncontrolled HT or DM in the Asian population. Epidemiological studies of cardiovascular disease should be conducted with continuous consideration of the changing disease risk profiles, lifestyles, and socioeconomic status over time. Objective We aimed to examine the association of uncontrolled HT or DM with the incidence of cardiovascular events or deaths from any cause. Methods This population-based retrospective study was conducted using data from the Korean National Health Insurance Service–National Health Screening Cohort, including patients aged 40-79 years who participated in national screening from 2002 to 2003 and were followed up until 2015. The health screening period from 2002 to 2013 was stratified into 6 index periods in 2-year cycles, and the follow-up period from 2004 to 2015 was stratified accordingly into 6 subsequent 2-year periods. The incidence rates and hazard ratio (HR) for major adverse cardiovascular events (MACE) and death from any cause were estimated according to HT or DM control status. Extended Cox models with time-dependent variables updated every 2 years, including sociodemographic characteristics, blood pressure (BP), fasting blood glucose (FBG), medication prescription, and adherence, were used. Results Among the total cohort of 440,249 patients, 155,765 (35.38%) were in the uncontrolled HT or DM group. More than 60% of the patients with HT or DM who were prescribed medications did not achieve the target BP or FBG. The incidence of MACE was 10.8-15.5 and 9.6-13.3 per 1000 person-years in the uncontrolled DM and uncontrolled HT groups, respectively, and increased with age. In the uncontrolled HT and DM group, the incidence of MACE was high (15.2-17.5 per 1000 person-years) at a relatively young age and showed no age-related trend. Adjusted HR for MACE were 1.28 (95% CI 1.23-1.32) for the uncontrolled DM group, 1.32 (95% CI 1.29-1.35) for the uncontrolled HT group, and 1.54 (95% CI 1.47-1.60) for the uncontrolled HT and DM group. Adjusted HR for death from any cause were 1.05 (95% CI 1.01-1.10) for the uncontrolled DM group, 1.13 (95% CI 1.10-1.16) for the uncontrolled HT group, and 1.17 (95% CI 1.12-1.23) for the uncontrolled HT and DM group. Conclusions This up-to-date evidence of cardiovascular epidemiology in South Korea serves as the basis for planning public health policies to prevent cardiovascular diseases. The high uncontrolled rates of HT or DM, regardless of medication prescription, have led us to suggest the need for a novel system for effective BP or glycemic control, such as a community-wide management program using mobile health technology.
Asymptotically Efficient Estimation of Cointegration Regressions

An asymptotic optimality theory for the estimation of cointegration regressions is developed in this paper. The theory applies to a reasonably wide class of estimators without making any specific assumptions about the probability distribution or short-run dynamics of the data-generating process. Due to the nonstandard nature of the estimation problem, the conventional minimum variance criterion does not provide a convenient measure of asymptotic efficiency. An alternative criterion, based on the concentration or peakedness of the limiting distribution of an estimator, is therefore adopted. The limiting distribution of estimators with maximum asymptotic efficiency is characterized in the paper and used to discuss the optimality of some known estimators. A new asymptotically efficient estimator is also introduced. This estimator is obtained from the ordinary least-squares estimator by a time domain correction which is nonparametric in the sense that no assumption of a finite parameter model is required. The estimator can be computed with least squares without any initial estimations.
Reprotoxicity induced by acute exposure to aqueous tuber extract of Peruvian Maca (Lepidium meyenii Walp.) in Caenorhabditis elegans

Maca (Lepidium meyenii Walp.) has been used in folk medicine to treat fertility disturbances, a claim that has been evidenced in some studies. However, the clinical trials validating this use have shown paradoxical findings and then maca safety is not well known. This study investigated the effects and mechanisms by which maca affects the reproductive system using an in vivo model, the nematode Caenorhabditis elegans. Tuber maca powder, obtained from local commerce, was used to prepare the aqueous extract. Worms were acutely exposed to maca extracts (40, 120, 240, and 330 μg/μl), and 48 h after treatments, physiological and biochemical assays were conducted. Maca extract caused a significant decrease in total number of eggs and in the number of eggs per worm. These effects were associated to increased lipid peroxidation, reduced triacylglycerol levels, and also impaired vit‐2 (vitellogenin) expression, besides increase in the number of apoptotic germline cells. We have found quantifiable levels of alkaloids in this maca extract, which presence could be related to this toxicity. Collectively, our data suggest that maca extract exposure causes reproductive toxicity to worms that could be, at least in part, associated to both an increase in apoptosis of germline cells and also to a decrease in vitellogenin expression, needed for egg yolk production and, consequently, successful reproduction.
The pre-anesthetic period is the best time to evaluate the knee flexion angle for predicting the flexion angle after total knee arthroplasty: A prospective cohort study

Introduction Knee flexion angle (KFA) is one of the most critical factors for evaluating patient functional outcomes after total knee arthroplasty (TKA). Preoperative KFA and intraoperative drop leg test are both accepted as predictors of postoperative KFA after TKA. Preoperative testing performed after anesthesia helps overcome pain-related limitations; however, the KFA measurement timepoint that best predicts KFA at 6 months after TKA has not yet been established. Methods This prospective cohort study recruited patients who underwent unilateral primary TKA at Siriraj Hospital (Bangkok, Thailand) during August 2012 to August 2017. We recorded KFA at the pre-anesthetic phase, post-anesthetic phase, intraoperation using drop leg test, and at 6-months post-operation. Pearson’s correlation coefficient was used to evaluate correlation between different measurement timepoints and 6 months after surgery. Those same relationships were evaluated for overall patients, and for patients with KFA <90° (poor KFA), 90–120° (average KFA), and >120° (high KFA). Results A total of 165 patients with a mean age of 68.7 years were recruited. Pre-anesthetic KFA measurement had the highest positive correlation with the 6-month KFA (r = 0.771, p<0.05). Post-anesthetic measurement and intraoperative drop leg KFA measurement had moderate positive correlation (r = 0.561, p<0.05) and low positive correlation (r = 0.368, p<0.05) with the 6-month KFA, respectively. The average KFA group had the highest positive correlation between pre-anesthetic KFA measurement and the 6-month KFA (r = 0.711, p<0.05). Predicted 6-month KFA (degrees) adjusted for pre-anesthetic KFA is 45.378 + [0.596 x pre-anesthetic KFA (degrees)] (r = 0.67, p <0.05). Conclusions Pre-anesthetic KFA demonstrated the highest correlation with the final KFA at six months after unilateral primary TKA, especially in the patients who had a preoperative KFA within 90–120°.
Analytical detection sensitivity of the laser-probed resonant Voigt effect

Analytical detection sensitivity of the resonant magneto-optic effect in the Voigt configuration (transverse magnetic field) was investigated by using a narrow-band tunable dye laser as a light source and sodium atoms in a flame as a sample. The elliptically polarized laser beam was tuned to the sodium D2 line. The signal-to-noise ratio was optimized by adjusting the ellipticity of incident light and the orientation of the polarization analyzer. The observed profiles of the Voigt signal agreed with the theoretical prediction. The detection sensitivity of the Voigt effect was enhanced by a factor of 2 × 102 when compared with the atomic absorption in the same experimental arrangement. The absolute values of the atomic-number density obtained from the Voigt effect and the absorption agreed within the experimental accuracy.
Association of hyperuricemia with cardiovascular diseases: current evidence

ABSTRACT The aim of the present study is to present a historical and unified perspective on the association of serum uric acid (SUA) in the cause of cardiovascular diseases (CVDs). The association of hyperuricemia (HUC) with CVD begun to be appreciated in the middle 1950s and early 1990s when clinical evidence was shown on the association of HUC with CVD. However, this association was disputed by several investigators including the Framingham group and by professional societies, like the American Heart Association and the American Society of Hypertension. This dispute was weakened or reversed by later studies, which showed a positive association of HUC with CVD, CHD, HF, CKD, and stroke, mediated by several risk factors, both molecular such as, oxidative stress, inflammatory stress, insulin resistance, and endothelial dysfunction, as well as clinical factors such as, atherosclerosis, hypertension, metabolic syndrome, and type 2 diabetes mellitus. The great majority of recent studies show a positive association of HUC with CVDs, and CKD. However, the cutoff of the damaging levels of SUA have not been established as yet. The European Society of Hypertension (ESH) Treatment Guidelines have proposed a cutoff level of SUA for CVD > 7 mg/dl for men and > 6 mg/dl for women. In contrast, the URRAH study has shown a SUA level of 4.7 mg/dl for all-cause mortality and 5.6 mg/dl for CV mortality. These levels are lower than the SUA levels proposed by the ESH, which are consistent with HUC. For a better understanding of this association, a Medline search of the English literature was conducted between 2015 and 2022 and 44 pertinent papers were selected. These papers together with collateral literature will be discussed in this review.
Stadium attendance demand in the men’s UEFA Champions League: Do fans value sporting contest or match quality?

This paper is the first to empirically analyse the determinants of stadium attendance demand in the men’s UEFA Champions League, the most prestigious competition in club football. The analysis covers 1,234 matches from 2009/10 to 2018/19 across 32 nations. The results show that outcome uncertainty and competitive intensity are not significantly associated with higher attendances, but the level of team quality is, for all fans, and the presence of star players is, for fans of clubs outside the top five European leagues. The empirical analysis—based on Tobit model regressions—enables an evidence-informed discussion of the competition structure of the UCL and the highly charged debate surrounding a potential European Super League. The article also offers insights for the wider body of academic knowledge on stadium attendance demand, by adding rare analysis of an international cup competition and an improved understanding of the connection between star players and fan interest in European football.
Increase in Colorado Tick Fever Virus Disease Cases and Effect of COVID-19 Pandemic on Behaviors and Testing Practices, Montana, 2020

In 2020, Montana, USA, reported a large increase in Colorado tick fever (CTF) cases. To investigate potential causes of the increase, we conducted a case–control study of Montana residents who tested positive or negative for CTF during 2020, assessed healthcare providers’ CTF awareness and testing practices, and reviewed CTF testing methods. Case-patients reported more time recreating outdoors on weekends, and all reported finding a tick on themselves before illness. No consistent changes were identified in provider practices. Previously, only CTF serologic testing was used in Montana. In 2020, because of SARS-CoV-2 testing needs, the state laboratory sent specimens for CTF testing to the Centers for Disease Control and Prevention, where more sensitive molecular methods are used. This change in testing probably increased the number of CTF cases detected. Molecular testing is optimal for CTF diagnosis during acute illness. Tick bite prevention measures should continue to be advised for persons doing outdoor activities.
Predicting Severity of Head Collision Events in Elite Soccer Using Preinjury Data: A Machine Learning Approach

Objective: To develop machine learning (ML) models that predict severity of head collision events (HCEs) based on preinjury variables and to investigate which variables are important to predicting severity. Design: Data on HCEs were collected with respect to severity and 23 preinjury variables to create 2 datasets, a male dataset using men's tournaments and mixed dataset using men's and women's tournaments, to perform ML analysis. Machine learning analysis used a random forest classifier based on preinjury variables to predict HCE severity. Setting: Four elite international soccer tournaments. Participants: Elite athletes participating in analyzed tournaments. Independent Variables: The 23 preinjury variables collected for each HCE. Main Outcome Measures: Predictive ability of the ML models and association of important variables. Results: The ML models had an average area under the receiver operating characteristic curve for predicting HCE severity of 0.73 and 0.70 for the male and mixed datasets, respectively. The most important variables for prediction were the mechanism of injury and the event before injury. In the male dataset, the mechanisms “head-to-head” and “knee-to-head” were together significantly associated (P = 0.0244) with severity; they were not significant in the mixed dataset (P = 0.1113). In both datasets, the events “corner kicks” and “throw-ins” were together significantly associated with severity (male, P = 0.0001; mixed, P = 0.0004). Conclusions: ML models accurately predicted the severity of HCE. The mechanism and event preceding injury were most important for predicting severity of HCEs. These findings support the use of ML to inform preventative measures that will mitigate the impact of these preinjury factors on player health.
Enhanced Maximal Upper-Body Strength Increases Performance in Sprint Kayaking

Abstract Kristiansen, M, Sydow Krogh Pedersen, A-M, Sandvej, G, Jørgensen, P, Jakobsen, JV, de Zee, M, Hansen, EA, and Klitgaard, KK. Enhanced maximal upper-body strength increases performance in sprint kayaking. J Strength Cond Res 37(4): e305–e312, 2023—The association between upper-body strength and performance in 200-m flat-water sprint kayak is not fully elucidated. Therefore, the aim of study 1 was to investigate the relationship between upper-body strength and kayaking performance. In study 2, the aim was to perform a randomized training intervention to investigate whether a causal relationship was present between an increase in strength and an actual change in 200-m kayaking performance. In study 1, 37 (22 men and 15 women) elite kayak paddlers performed tests of maximal power output, isometric force, 1 repetition maximum (1RM), and 40 seconds of maximal repetition number in bench press and bench pull and a 30-second all-out on-water sprint kayak test. In study 2, 26 (16 men and 10 women) national elite junior A, U23, and senior kayak paddlers were allocated into 2 groups: a training group (TRAIN) and a maintenance group (MAIN). Each group completed a 6-week strength training intervention with the purpose of either increasing 1RM in bench press (TRAIN) or maintaining strength (MAIN). Pre- and posttests were performed in 200-m kayak ergometer sprint, 1RM bench press, and 1RM bench pull. In study 1, 1RM in bench press was the best predictor of 30-second on-water kayaking performance with a regression coefficient of 0.474. In study 2, TRAIN significantly increased 1RM strength in bench press (pre: 87.3 ± 21.2 kg, post: 93.9 ± 21.3 kg, p = 0.001) and bench pull (pre: 84.2 ± 15.3 kg, post: 86.0 ± 15.1 kg, p = 0.025). In the 200-m kayak ergometer sprint test, TRAIN significantly decreased the time to complete the test (pre: 44.8 ± 4.3 seconds, post: 44.3 ± 4.3 seconds, p = 0.042). In bench press, 1RM was the best predictor of 200-m kayaking, and an increase in bench press 1RM resulted in increased kayaking performance.
Factors Associated With Willingness to Use Daily Antibiotics as Sexually Transmitted Infection Prophylaxis Among HIV Preexposure Prophylaxis–Experienced Gay and Bisexual Men in Australia

Willingness to use daily antibiotic for sexually transmitted infection preexposure prophylaxis was found among half of Australian HIV preexposure prophylaxis–experienced gay and bisexual men in our study. Background Gay and bisexual men (GBM) who use HIV preexposure prophylaxis (HIV-PrEP) have high rates of bacterial sexually transmitted infections (STIs). The use of daily antibiotics as STI preexposure prophylaxis (STI-PrEP) may be appealing to GBM who are using or have previously used HIV-PrEP (HIV-PrEP–experienced) for the prevention of bacterial STIs. Methods We examined willingness to use daily STI-PrEP among a cross-sectional sample of HIV-PrEP–experienced GBM in Australia who participated in an observational online cohort study from August 2018 to March 2020. Factors associated with willingness to use daily STI-PrEP were determined using bivariate and multivariate logistic regression. Results Of the 1347 participants, half (54.3%) were willing to use daily STI-PrEP. Factors independently associated with greater willingness to use daily STI-PrEP included having >10 sexual partners in the last 6 months, using methamphetamine in the last 6 months, being more conscious about avoiding STIs, having a greater number of STIs since commencing HIV-PrEP, being willing to take HIV-PrEP for as long as they were at risk of acquiring HIV, and only using condoms when a sexual partner requested them. Conversely, factors associated with less willingness to use daily STI-PrEP included being university educated, using nondaily dosing regimens of HIV-PrEP, preferring event-driven HIV-PrEP, and being concerned about long-term HIV-PrEP adverse effects. Conclusions Sexually transmitted infection PrEP is likely to be appealing to many HIV-PrEP–experienced GBM, especially those who engage in activities associated with a higher risk of STI transmission. However, they are less likely to be willing to use STI-PrEP unless it aligns with their HIV-PrEP dosing regimen, suggesting that research into the safety and efficacy of alternative STI prophylaxis dosing options should be prioritized.