Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase 1/2 study evaluating the safety and efficacy of DSP‐7888 dosing emulsion in myelodysplastic syndromes

DSP‐7888 is an immunotherapeutic cancer vaccine derived from the Wilms’ tumor gene 1 (WT1) protein. This phase 1/2 open‐label study evaluated the safety and efficacy of DSP‐7888 dosing emulsion in patients with myelodysplastic syndromes (MDS). DSP‐7888 was administered intradermally (3.5 or 10.5 mg) every 2 weeks for 6 months and then every 2‐4 weeks until lack of benefit. Twelve patients were treated in phase 1 (3.5 mg, n = 6; 10.5 mg, n = 6), with no dose‐limiting toxicities reported. Thus, the 10.5 mg dose was selected as the recommended phase 2 dose, and 35 patients were treated in phase 2. Forty‐seven patients received ≥1 dose of the study drug and comprised the safety analysis set. The most common adverse drug reaction (ADR) was injection site reactions (ISR; 91.5%). Grade 3 ISR were common (58.8%) in phase 1 but occurred less frequently in 2 (22.9%) following implementation of risk minimization strategies. Other common ADR were pyrexia (10.6%) and febrile neutropenia (8.5%). In the efficacy analysis set, comprising patients with higher‐risk MDS after azacitidine failure in phases 1 and 2 (n = 42), the disease control rate was 19.0%, and the median overall survival (OS) was 8.6 (90% confidence interval [CI], 6.8‐10.3) months. Median OS was 10.0 (90% CI, 7.6‐11.4) months in patients with a WT1‐specific immune response (IR; n = 33) versus 4.1 (90% CI, 2.3‐8.1) months in those without a WT1‐specific IR (n = 9; P = .0034). The acceptable safety and clinical activity findings observed support the continued development of DSP‐7888 dosing emulsion.
Bowtie patch antennas and simple arrays for wireless indoor communications

Several bowtie patch-antenna configurations are studied for their suitability for use in broad-band indoor wireless communications. A microstrip bowtie antenna (MBA), based on the design of equilateral triangular patches, is first designed and tested. The same design is used to realize a coplanar-waveguide bowtie antenna (CPWBA) with finite ground plane. The CPWBA is coax-fed from its apex and matched in C-band. The resonant slot length of this antenna is around three times that of the guided wavelength. The measured gain for the CPWBA antenna is 8.1 dB. The same MBA is also used in the realization of (1/spl times/2)-, (2/spl times/1)-, and (2/spl times/2)-element MBA arrays. The MBA and resultant arrays use microstrip feed networks matched to the input impedance at around 10 GHz. The gain of the MBA is 6.2 dB; the gains for the arrays vary within 13.7 and 17.3 dB. The 2:1 voltage standing-wave ratio bandwidths lie in the 9.7%-10.8% range for the realized antennas. The radiation patterns can be optimized to fit the required diversity for the specific indoor wireless communication environment; the beamwidths are demonstrated to vary between 15/spl deg/ and 85/spl deg/, which allow for multipath minimization and radiation diversity within the premises, thereby providing interference-free illumination.
On the Importance of High–Fidelity Numerical Modelling of Ocean Wave Energy Converters under Controlled Conditions

Abstract. Numerical modelling tools are commonly applied during the development and optimisation of ocean wave energy converters (WECs). Models are available for the hydrodynamic wave structure interaction, as well as the WEC sub–systems, such as the power take–off (PTO) model. Based on the implemented equations, different levels of fidelity are available for the numerical models. Specifically under controlled conditions, with enhance WEC motion, it is assumed that non-linearities are more prominent, re- quiring the use of high–fidelity modelling tools. Based on two different test cases for two different WECs, this paper highlights the importance of high–fidelity numerical modelling of WECs under controlled conditions.
IMPACT OF DIFFERENT LEVELS OF BULK DENSITIES COMBINATION ON YIELD AND YIELD COMPONENT OF WHEAT (TRITICUM AESTIVUM L.)

An experiment was conducted on the impact of different levels of bulk densities combination on yield and yield components of wheat. Three bulk density levels 1.00-1.30 (A) g cm-3, 1.30-1.60 (B) g cm-3 and 1.60-1.90 (C) g cm-3 with three different depths (0-15, 16-30 and 31-45 cm) were used in the experiment using silt loam soil (Pedocals). The total treatments were 27 in the experiment with three replications. The experimental design was completely randomized design (CRD). The treatment means were checked at the confidence level of 95% of probability. The soil 0-45 cm deep was shifted from the field (no-till) to the net house and was act as control. The results showed that the number of tillers plant-1, number of leaves plant-1 and thousand grain yield were non-significantly affected by all the treatments while number of seed emerged, root length, dry root weight, plant height, grain yield , biological yield and harvest index were significantly influenced by various treatments. The highest number of seed germinated (8.00) was found in the treatment BBB (1.30-1.60 g cm-3 in 0-15 cm, 15-30 cm, 30-45 cm soil depth), BAB (1.30-1.60 g cm-3 in 0-15 cm, 1.00-1.30 g cm-3 in 15-30 cm and 1.30-1.60 g cm-3 in 30-45 cm soil depth) and BCB (1.30-1.60 g cm-3 in 0-15 cm, 1.60-1.90 g cm-3 in 15-30 cm and 1.30-1.60 g cm-3 in 30-45 cm) while the lowest number of seed emerged (3.6) was found in AAA (1.00-1.30 g cm-3 in 0-15 cm, 15-30 cm and 30-45 cm soil depth), ACA (1.00-1.30 g cm-3 in 0-15 cm, 1.60-1.90 g cm-3 in 15-30 cm and 1.00-1.30 g cm-3 in 30-45 cm soil depth) and CAC (1.60-1.90 g cm -3 in 0-15 cm, 1.00-1.30 g cm-3 in 15-30 cm and 1.60-1.90 g cm-3 in 30-45 cm soil depth). The highest root length (13.12 cm) was found in the treatment AAA while the lowest root length (10.05 cm) was found in CAC. The highest dry root weight (5.67g) was found in the treatment ABA while the lowest dry root weight (4.79g) was found in control treatment. The highest plant height (42.67 cm) was found in the treatment of BBA while the lowest plant height (29.67 cm) was found in control. The highest biological yield (12.1 metric ton ha-1) was found in the treatment ABA while the lowest biological yield (6.8 metric ton ha-1) was found in control. The highest grain yield (4.4 metric ton ha-1) was found by ABB while the lowest (2.7 metric ton ha-1) was found in the control. The highest harvest index (39.79%) was found in the control while the lowest harvest index (34.54%) was found in CCA. The experiment showed that increasing bulk density above 1.60 g cm-3 resulted in decreasing the yield and yield component of the winter wheat. The number of seed emerged, root length, dry root weight, plant height, grain yield, biological yield and harvest index of wheat were significantly affected by soil bulk density in various depths.
Clear the Fog: Towards a Taxonomy of Self-Sovereign Identity Ecosystem Members

The current Self-Sovereign Identity (SSI) ecosystem is rapidly changing and ill-defined. Manifold actors, projects, and initiatives produce different SSI solutions, frameworks, protocols, and distributed ledgers. Even though some patterns exist among SSI ecosystem members, no elaborate systematization has been made. This paper conducts a systematic gray literature review to structure the SSI ecosystem. Specifically, we derive a four-dimensional taxonomy that portrays members of the SSI ecosystem. Then, we classify the ecosystem members into eight archetypes. The goals are to allow researchers to describe SSI ecosystem members, help new and existing members locate themselves within the SSI ecosystem, and provide an overview of members’ functionalities. We find that SSI ecosystem members either govern the SSI ecosystem and/or networks, implement SSI offerings, or support governing and/or implementing members. The study suggests that, as the SSI ecosystem grows, the number of governing members will grow slower than the number of implementing and supporting members.
Bacterial outer membrane vesicles induce a transcriptional shift in arabidopsis towards immune system activation leading to suppression of pathogen growth in planta

Gram negative bacteria form spherical blebs on their cell periphery, which later dissociate and released into the surrounding environment. Previous studies have shown that these nano scale structures, derived primarily from the bacterial outer membrane and are termed outer membrane vesicles (OMVs), induce typical immune outputs in both mammals and plants. On the other hand, these same structures have been shown to promote infection and disease. To better understand the broad transcriptional change plants undergo following exposure to OMVs, we treated Arabidopsis thaliana (Arabidopsis) seedlings with OMVs purified from the Gram-negative plant pathogenic bacterium Xanthomonas campestris pv. campestris and performed RNA-seq analysis on OMV- and mock-treated samples at 2, 6 and 24 h post challenge. We found that the most pronounced transcriptional shift occurred in the first two time points, as was reflected by both the number of differentially expressed genes (DEGs) and the average fold change. Gene ontology enrichment analysis revealed that OMVs induce a major transcriptional shift in Arabidopsis towards immune system activation, upregulating a multitude of immune-related pathways including a variety of immune receptors and transcriptional factors. Comparing Arabidopsis response to OMVs and to single purified elicitors, revealed that while OMVs induce a similar suite of genes and pathways as single elicitors, some differential pathways activated by OMVs were detected including response to drug and apoptosis, which may indicate exposure to toxic compounds via OMV. To examine whether the observed transcriptional shift in Arabidopsis leads to an effective immune response, plants were pretreated with OMVs and then inoculated with a bacterial pathogen. OMV-mediated priming led to a significant reduction in bacterial titer in inoculated leaves two days following inoculation. Mutations in the elongation factor receptor (EFR), flagellin receptor (FLS2), or the brassinosteroid-insensitive 1–associated kinase (BAK1) receptor, did not significantly affect OMV-priming. All together these results show that OMV induce a broad transcriptional shift in Arabidopsis leading to upregulation of multiple immune pathways, and that this transcriptional change is reflected in the ability to better resist bacterial infection.
Estimation of Rutting Models by Combining Data from Different Sources

The accurate prediction of rutting development is an essential element for the efficient management of pavement systems. The objective of this paper is to demonstrate the effectiveness of the estimation of rutting models by combining the information from two data sources, the AASHO and the WesTrack road tests. Combined estimation with both data sources is used to identify parameters that are not identifiable from one data source alone. In addition, this estimation approach also yields more efficient parameter estimates. The results presented in this paper demonstrate that joint estimation produces more realistic parameter estimates than those obtained by using either data set alone. Furthermore, joint estimation allows us to account for the effects of pavement structure, axle load configuration, asphalt concrete mix properties, freeze-thaw cycles, and hot temperatures in a single model. Finally, it allows us to predict the relative contributions of rutting originating both in the asphalt concrete and in t.
RIACS FY2002 Annual Report

The Research Institute for Advanced Computer Science (RIACS) carries out basic research and technology development in computer science, in support of the National Aeronautics and Space Administration's missions. Operated by the Universities Space Research Association (a non-profit university consortium), RIACS is located at the NASA Ames Research Center, Moffett Field, California. It currently operates under a multiple year grant/cooperative agreement that began on October 1, 1997 and is up for renewal in September 2003. Ames has been designated NASA's Center of Excellence in Information Technology. In this capacity, Ames is charged with the responsibility to build an Information Technology (IT) Research Program that is preeminent within NASA. RIACS serves as a bridge between NASA Ames and the academic community, and RIACS scientists and visitors work in close collaboration with NASA scientists. RIACS has the additional goal of broadening the base of researchers in these areas of importance to the nation's space and aeronautics enterprises. RIACS research focuses on the three cornerstones of IT research necessary to meet the future challenges of NASA missions: 1) Automated Reasoning for Autonomous Systems; 2) Human-Centered Computing; and 3) High Performance Computing and Networking. In addition, RIACS collaborates with NASA scientists to apply IT research to a variety of NASA application domains including aerospace technology, earth science, life sciences, and astrobiology. RIACS also engages in other activities, such as workshops, seminars, visiting scientist programs and student summer programs, designed to encourage and facilitate collaboration between the university and NASA IT research communities.
The Third-Order Elastic Constants and Mechanical Properties of 30° Partial Dislocation in Germanium: A Study from the First-Principles Calculations and the Improved Peierls–Nabarro Model

The elastic constants, core width and Peierls stress of 30° partial dislocation in germanium has been investigated based on the first-principles calculations and the improved Peierls–Nabarro model. Our results suggest that the predictions of lattice constant and elastic constants given by LDA are in better agreement with experiment results. While the lattice constant is overestimated at about 2.4% and most elastic constants are underestimated at about 20% by the GGA method. Furthermore, when the applied deformation is larger than 2%, the nonlinear elastic effects should be considered. And with the Lagrangian strains up to 8%, taking into account the third-order terms in the energy expansion is sufficient. Except the original γ—surface generally used before (given by the first-principles calculations directly), the effective γ—surface proposed by Kamimura et al. derived from the original one is also used to study the Peierls stress. The research results show that when the intrinsic−stacking−fault energy (ISFE) is very low relative to the unstable−stacking−fault energy (USFE), the difference between the original γ—surface and the effective γ—surface is inapparent and there is nearly no difference between the results of Peierls stresses calculated from these two kinds of γ—surfaces. As a result, the original γ—surface can be directly used to study the core width and Peierls stress when the ratio of ISFE to the USFE is small. Since the negligence of the discrete effect and the contribution of strain energy to the dislocation energy, the Peierls stress given by the classical Peierls–Nabarro model is about one order of magnitude larger than that given by the improved Peierls–Nabarro model. The result of Peierls stress estimated by the improved Peierls–Nabarro model agrees well with the 2~3 GPa reported in the book of Solid State Physics edited by F. Seitz and D. Turnbull.
Centrifugal compressor performance assessment under different impeller tip clearance sizes from far to near stall conditions

Impeller tip clearance is a key parameter in design process of a centrifugal compressor which has influential effects on its aerodynamic and thermodynamic performances. Interaction of tip leakage flow with the main stream could be the major source for occurrence of stall phenomenon. In the present investigation, two impeller tip clearances of small and large sizes are investigated under different flow coefficients assigned to “design”, “low flow” and “high flow” conditions. Flow field is precisely simulated utilizing solution of the Reynolds-Averaged Navier-Stokes equations. Influence of the impeller stall on the volute flow field is studied. Structure of vortical flows within the impeller passages and volute are demonstrated in details. Numerical results showed that the flow within the volute becomes stall-prone while the flow within the impeller stalls. In contrast to the high flow case, the low flow condition was more prone for the stall occurrence. Performance tests were also conducted on Iran University of Science and Technology (IUST) centrifugal compressor test rig for validation of the numerical results.
Response Prediction of Static Modal Testing on Milling Machine Tool

Milling is one of the most common manufacturing processes for automotive component, but its productivity is limited by chatter. This form of chatter is undesirable because it results in premature tool wear, poor surface finish on the machined component and the possibility of serious damage to the machine itself. Modal testing is a form of vibration testing which is able to determine the Frequency Response Function (FRF) of the mechanical test structures. In this paper, the main focus is to obtain natural frequency values for machine tool components in order to establish better conditions in the cutting process on the machine tool. For this purpose, a 3D model of the machine tool’s part is made using design software and exported to analysis software. Later on, the Finite Element Method (FEM) modal analysis was used to obtain the natural frequencies. The model is evaluated and corrected through an experimental modal test. In the experiment, the machine tool vibration is excited by impact hammer and the response of excited vibration is recorded. In the end, the result of both FEM and experimental shows a good consistency in comparison.
Perspective versus Plan View Air Traffic Control Displays: Survey and Empirical Results

A survey was distributed and an experiment was performed to analyze two air traffic control (ATC) color-coded display formats: (1) the currently used plan view display format, and (2) a perspective display format. The results of both the survey and experiment were used to extract specific user requirements from which specifications could be applied to design a three-dimensional, dynamic, color-coded, perspective display for use in an ATC environment. The emphasis of the survey and current experiment focused on the air traffic controller's point of view in terms of cognitive workloads, task and information requirements, color preferences, and air traffic workloads relative to traffic density and complexity. Fifteen full-performance air traffic controllers performed three timed tasks: (1) resolve impending air traffic conflicts, (2) identify the callsigns of aircraft in the highest and lowest actual altitudes, and (3) reconstruct air traffic situations. Two levels of traffic density were crossed with two display types for six different ATC scenarios. The results indicated that for the conflict resolution task performance was faster for the perspective display format only in the lower density level, and performance was the same for both display types in the higher density level. Performance for altitude extraction task for both density levels was faster for the perspective display format than for the plan view display format. Performance was the same for the reconstruction task for both display types and both density levels. Finally, performance was faster for the conflict resolution task than for the altitude extraction task across both display types and both density levels.
An analytical model of MAGFET sensitivity including secondary effects using a continuous description of the geometric correction factor G

An analytical model of the sensitivity of magnetic field-effect transistors (MAGFET's) is presented. The model includes secondary and parasitic geometric effects as well as operating point dependencies. In order to get a continuous mathematical description for the sensitivity, we introduce a continuous function for the geometric correction factor G. This description of G is not limited to MAGFET's and can be used for any magnetic device.
MicroRNA-202 Induces Myoblast to Myocyte Differentiation through Targeting Rock-1

Abstract The expression patterns of microRNAs (small non-coding RNAs) are altered in many biological processes such as myogenesis. In this study, we aimed to investigate the impact of predicted miR-202, its target genes Akt2 and Rock-1 as a potential regulator of myoblast in the myocyte differentiation process using the C2C12 cell line. After confirmation of the differentiation process induced by 3% horse serum, the expression level of miRNA and its targets were evaluated. In the following, a luciferase assay was conducted to approve the effect of miRNA on its target. Our results indicated that miR-202 and Akt2 were significantly up-regulated during differentiation, while Rock-1 was downregulated. Co-transfection of miRNA with psiCHECK2-Rock-1 significantly presented that Rock-1 was directly targeted by miR-202. On the contrary, miR-202 has failed to enforce its inhibitory effect on Akt2 expression. In particular, miR-202 seems to be a regulator of muscle differentiation pathway thought targeting Rock-1.
From Shunt to Recovery: A Multidisciplinary Approach to Hydrocephalus Treatment in Severe Acquired Brain Injury Rehabilitation

Background: Hydrocephalus among Severe Acquired Brain Injury (SABI) patients remains overlooked during rehabilitation. Methods: A retrospective cohort study was carried out of traumatic and non-traumatic SABI patients with hydrocephalus, consecutively admitted over 9 years in a tertiary referral specialized rehabilitation hospital. Patients were treated with ventriculoperitoneal shunt before or during inpatient rehabilitation and assessed using the Level of Cognitive Functioning Scale and Disability Rating Scale. Logistic regression models were used to identify predictors of post-surgical complications. Linear regression models were used to investigate predictors of hospital length of stay (LOS), disability, and cognitive function. Results: Of the 82 patients, 15 had post-surgical complications and 16 underwent cranioplasty. Shunt placement complication risk was higher when fixed vs. when programmable pressure valves were used. A total of 56.3% achieved functional improvement at discharge and 88.7% improved in cognitive function; of the 82 patients, 56% were discharged home. In multiple regression analyses, higher disability at discharge was related to cranioplasty and longer LOS, while poorer cognitive function was associated with cranioplasty. Increase in LOS was associated with increasing time to shunt and decreasing age. Conclusions: A significant improvement in cognitive and functional outcomes can be achieved. Cranioplasty increased LOS, and fixed pressure valves were related to poorer outcomes.