Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance assessment of ensembles of in situ workflows under resource constraints

Scientific breakthroughs in biomolecular methods and improvements in hardware technology have shifted from a long‐running simulation to a large set of shorter simulations running simultaneously, called an ensemble. In an ensemble, simulations are usually coupled with analyses of data produced by the simulations. In situ methods can be used to analyze large volumes of data generated by scientific simulations at runtime (i.e., simulations and analyses are performed concurrently). In this work, we study the execution of ensemble‐based simulations paired with in situ analyses using in‐memory staging methods. Using an ensemble of molecular dynamics in situ workflows with multiple simulations and analyses, we first show that collecting traditional metrics such as makespan, instructions per cycle, memory usage, or cache miss ratio is not sufficient to characterize complex behaviors of ensembles. We propose a method to evaluate the performance of ensembles of workflows that captures multiple resource usage aspects: resource efficiency, resource allocation, and resource provisioning. Experimental results demonstrate that the proposed method can effectively distinguish the performance of different component placements in an ensemble with up to 32 ensemble members. By evaluating different co‐location scenarios, our proposed performance indicators demonstrate benefits of co‐locating simulation and coupled analyses within a compute node.
The Regulatory Effect of Eugenol on FSHR, LHCGR, and ER Expression during Follicular Development in Female Rats With Ovarian Torsion

Objectives: This study aimed to investigate the role of Eugenol in regulating the expression of FSH receptor (FSHR), human luteinizing hormone choriogonadotropin receptor (LHCGR), and estrogen receptor (ER) during follicular development in female rat ovarian torsion. Materials and Methods: In this experimental study, 48 female rats were randomly assigned to 4 groups, including G1 (i.e., sham), G2 (i.e., ovarian torsion/detorsion group), G3 (i.e., ovarian torsion/detorsion group treated with 30 mg/kg of eugenol), G4 (i.e., healthy group treated with 30 mg/kg of eugenol). After covering a treatment period of ten days, the ovarian tissue was collected for the histological analysis, the measurement of ER, FSHR, and LHCGR expression, as well as the assessment of testosterone, LH, FSH, and estrogen levels in blood serum. Results: Histological evaluation revealed the damage to ovarian tissue, the reduced oocyte, and the granulosa cell diameter in the torsion/detorsion group. However, the treatment with eugenol mitigated this damage. Eugenol administration increased the levels of estrogen, LH, and FSH, but it decreased the testosterone levels in the treated group. Moreover, the expression of ER, FSHR, and LHCGR was upregulated in the treated groups. Administration of eugenol was associated with an enhanced fertility. Conclusions: It was concluded that eugenol administration may have been effective in protecting the ovarian tissue from the damage caused by torsion/detorsion. Furthermore, eugenol was found to have the potential to modulate hormonal profiles and regulate the expression of ER, FSHR, and LHCGR, thereby contributing to an increased fertility.
Telling Young Lives: Portraits of Global Youth

Foreword Acknowledgements 1. Introduction 2. Saka: Growing Up in the Indian Himalayas 3. "All My Life, I've Bounced Around": A Portrait of Blacc 4. Vusi Majola: "Walking Until the Shoes Is Finsihed" 5. Young, White, Male, and Working Class: A Portrait of Richard 6. Young, Male, Scottish, and Muslim: A Portrait of Kabir 7. Politics, Lifestyle, and Identity: The Story of Sven, Eastern Germany 8. "Each and Every Single Story About Me.There's Like a Huge Twist to It": Growing Up at Risk in the United States -A A Portrait of Mike 9. Zilho's Journeys: Displacement and Return in Bosnia-Herzegovina 10. Rocks: A Portrait of Mohammed 11. From Footballs to Fixer: Suresh and the New Politicians in North India 12. Telling Nala's Story: Negotiating the Global Agendas and Local Politics of Maasai Development in Tanzania 13. Darkest Whiteness: Race, Class, and Culture in Global Times: A Portrait of Helena 14. Young, Deaf, and Lesbian: A Portrait of Susannah 15. Afterword: Global Portraits and Local Snapshots About the Contributors Index
Reply to Comment on “Moist Static Energy Transport Trends in Four Global Reanalyses: Are They Downgradient?” by Clark et al. (2022)

In a previous study, we investigated whether reanalysis moist static energy (MSE) transport trends over the 1980 through 2018 period are consistent (a) with each other and (b) with the finding that these transport trends are downgradient, as found in climate models. Regarding point (a), our conclusion was that MSE transport trends were dependent on the reanalysis data set. However, Cox et al. (2023) correctly point out that the reanalysis dependence is reduced dramatically if a barotropic mass flux correction is applied at a monthly mean timescale prior to computing the MSE transport trends. In our reply below, we revisit point (b) after applying this correction. We find that even after the correction, reanalysis MSE transport trends are not downgradient nor poleward in the Northern Hemisphere extratropics. However, reanalysis does show a compensation between dry static and latent energy transport trends, which has been shown in climate models historically.
Effects of postural threat on perceptions of lower leg somatosensory stimuli during standing

Height-induced postural threat affects emotional state and standing balance behaviour during static, voluntary, and dynamic tasks. Facing a threat to balance also affects sensory and cortical processes during balance tasks. As sensory and cognitive functions are crucial in forming perceptions of movement, balance-related changes during threatening conditions might be associated with changes in conscious perceptions. Therefore, the purpose of this study was to examine the changes and potential mechanisms underlying conscious perceptions of balance-relevant information during height-induced postural threat. A combination of three experimental procedures utilized height-induced postural threat to manipulate emotional state, balance behavior, and/or conscious perceptions of balance-related stimuli. Experiment 1 assessed conscious perception of foot position during stance. During continuous antero-posterior pseudorandom support surface rotations, perceived foot movement was larger while actual foot movement did not change in the High (3.2 m, at the edge) compared to Low (1.1 m, away from edge) height conditions. Experiment 2 and 3 assessed somatosensory perceptual thresholds during upright stance. Perceptual thresholds for ankle rotations were elevated while foot sole vibrations thresholds remained unchanged in the High compared to Low condition. This study furthers our understanding of the relationship between emotional state, sensory perception, and balance performance. While threat can influence the perceived amplitude of above threshold ankle rotations, there is a reduction in the sensitivity of an ankle rotation without any change to foot sole sensitivity. These results highlight the effect of postural threat on neurophysiological and cognitive components of balance control and provide insight into balance assessment and intervention.
Potential Local Mechanisms for Exercise-Induced Hypoalgesia in Response to Blood Flow Restriction Training

Overall, there is a great need within sports medicine to ensure that athletes can return from injury in an efficient, yet thorough manner. It is crucial to not avoid necessary difficulties in this process but also to ensure time-efficient rehabilitation. One of the more promising techniques to achieve timely recovery is blood flow restriction (BFR) training. BFR training is a growing and novel development that could be a vital tool to lighten the burden of recovery from injury in athletes. BFR utilizes a pneumatic tourniquet to limit blood flow in specific areas of the body. The use of BFR has been shown to potentially enhance the analgesic effects of exercise-induced hypoalgesia (EIH). By limiting pain, athletes will be less burdened by mobility and loading exercises required for them to effectively return to play. In a field where time away from sports can have massive implications, the need for tools to assist in the acceleration of the rehabilitation process is vital. Much of the work that has already been done in the field has been able to exploit the benefits of EIH and further enhance the body’s capabilities through BFR. Studies have compared EIH at low- and high-intensity settings utilizing BFR with both resistance and aerobic exercise. The results of these studies show comparable beta-endorphin levels with high-intensity exercise without BFR and low-intensity exercise with BFR. Low-intensity training with BFR had greater local pain relief, perhaps indicating the promising effects of BFR in enhancing EIH. By reviewing the current literature on this topic, we hope that further progress can be made to better understand the mechanism behind BFR and its ability to enhance EIH. Currently, local metabolites are a major focus for the potential mechanism behind these effects. Mas-related G-protein-coupled receptors (Mrgprs) contribute to local pain pathways via mast cell degranulation. Similarly, chemokine receptor 2/chemokine ligand 2 (CCR2/CCL2) triggers mast cell degranulation and inflammation-induced pain. Finally, pain-reducing effects have been linked to anti-inflammatory IL-10 signaling and anaerobic metabolites via transient receptor potential vanilloid 1 (TRPV1). Through a better understanding of these metabolites and their mechanisms, it is possible to further exploit the use of BFR to not only serve athletes recovering from injury but also apply this information to better serve all patients.
Airborne Laser Hydrography: System Design and Performance Factors

Abstract : The National Ocean Service (NOS) within NOAA is the agency responsible for charting U.S. coastal waters and the Great Lakes. Methods are being sought to improve the efficiency of shallow-water hydrography. In 1980, NOS spent $10 million to operate a fleet of hydrographic survey vessels which use sonar to acquire shallow-water data for the production of nautical charts. The cost of hydrographic surveys for charting purposes has increased steadily as a result of inflationary pressures, the increased amount of surveying performed, and the need for more thorough surveys. Ways are sought to counter this trend by pursuing means for reducing cost, manpower, and data collection time while simultaneously improving sounding distribution and increasing productivity to satisfy growing user requirements. Such improvements are acceptable, however, only as long as the resulting data continues to meet the stringent accuracy standards established by the International Hydrographic Bureau (IHB).
Knowledge of Chronic Obstructive Pulmonary Diseases among Healthcare Workers: Nigerian COPD Research Project (NICORP)

Background: Chronic obstructive pulmonary disease (COPD) is a preventable and treatable chronic inflammatory lung disease that often causes obstruction to airflow in the lungs. The main risk factor in Nigeria is long term exposure to indoor pollution from cooking with firewood and fossil fuel in poorly ventilated spaces. Aims/ objectives: The aim was to evaluate the level of COPD knowledge among healthcare workers (HCWs) in the southwestern state of Nigeria.Materials/ methods: Self-administered online BCKQ which is made up of 65 stem questions was used to evaluate the level of knowledge of HCWs. The overall score of individual participants was represented in percentages and frequencies. Tests of statistical significance like the Chi-square test are applied to find out the statistical significance of the difference in percentages. Univariate analysis was done using respondent knowledge about COPD as the dependent variable and the socio-demographic were identified as independent variables. A p-value of <0.05 was taken as statistically significant in the calculations of variables. Results: Four hundred and five healthcare workers were involved in this study, 53.3% of whom were females. The mean age of the study cohort was 48.7±0.55 years, significant majority (75.6%) of whom were <40 years. (p< 0.001). Majority of cohorts (39.3%) were doctors, while 32.0% were nurses. Only 11.7% had PhD or Fellowship as their highest educational qualification. The overall mean total score of cohorts on the Bristol COPD questionnaire was 51.9±21.9 %, with 40.4% having good scores and only 11.3% had excellent score. Mean knowledge scores were high among doctors (69.9±02.4), HCWs with medical fellowships /PhD (69.9±02.4) and had worked for <10 years. A positive correlation was demonstrated between age, level of education and knowledge score (p<0.05). Conclusion: This study examined knowledge of COPD among healthcare workers in the southwestern part of Nigeria and confirmed that the knowledge of COPD among healthcare workers was essentially good but there were serious gaps in knowledge observed in areas of vaccination, inhalational therapy, and use of inhaled and oral steroid.
Protective effects and possible mechanisms of catalpol against diabetic nephropathy in animal models: a systematic review and meta-analysis

Aim of the Study: Rehmannia glutinosa is a core Chinese herbal medicine for the treatment of diabetes and diabetic nephropathy (DN). It has been used for the treatment of diabetes for over 1,000 years. Catalpol is the main active compound in Rehmannia roots. Current evidence suggests that catalpol exhibits significant anti-diabetic bioactivity, and thus it has attracted increasing research attention for its potential use in treating DN. However, no studies have systematically evaluated these effects, and its mechanism of action remains unclear. This study aimed to evaluate the effects of catalpol on DN, as well as to summarize its possible mechanisms of action, in DN animal models. Materials and Methods: We included all DN-related animal studies with catalpol intervention. These studies were retrieved by searching eight databases from their dates of inception to July 2022. In addition, we evaluated the methodological quality of the included studies using the Systematic Review Center for Laboratory animal Experimentation (SYRCLE) risk-of-bias tool. Furthermore, we calculated the weighted standard mean difference (SMD) with 95% confidence interval (CI) using the Review Manager 5.3 software and evaluated publication bias using the Stata (12.0) software. A total of 100 studies were retrieved, of which 12 that included 231 animals were finally included in this review. Results: As compared to the control treatment, treatment with catalpol significantly improved renal function in DN animal models by restoring serum creatinine (Scr) (p = 0.0009) and blood urea nitrogen (BUN) (p < 0.00001) levels, reducing proteinuria (p < 0.00001) and fasting blood glucose (FBG) (p < 0.0001), improving kidney indices (p < 0.0001), and alleviating renal pathological changes in the animal models. In addition, it may elicit its effects by reducing inflammation and oxidative stress, improving podocyte apoptosis, regulating lipid metabolism, delaying renal fibrosis, and enhancing autophagy. Conclusion: The preliminary findings of this preclinical systematic review suggest that catalpol elicits significant protective effects against hyperglycemia-induced kidney injury. However, more high-quality studies need to be carried out in the future to overcome the methodological shortcomings identified in this review.
Gambogic Acid Inhibits Gastric Cancer Cell Proliferation through Necroptosis

Gambogic acid (GA) is a natural xanthonoid secreted by Garcinia hanburyi tree. It possesses anti-cancer activity in various types of cancers. In gastric cancer, it inhibits cell proliferation through increasing apoptosis. However, whether necroptosis is involved in the GA-induced proliferation inhibited in gastric cancer is unknown. In the present study, we found that RIPK1 specific inhibitor necrostatin-1 (Nec-1) attenuated GA-induced proliferation inhibition. GA treatment increased the phosphorylation of necroptosis-related proteins, RIPK1, RIPK3, and MLKL, and their interactions to form the necrosome complex. The effector protein Drp-1 was dephosphorylated by GA treatment. Inhibition of necroptosis by different inhibitors and PGAM5 knockdown attenuated GA-induced cell death in gastric cancer cell lines, thereby attenuating GA-caused cell proliferation inhibition. All the data supported the conclusion that GA could inhibit gastric cancer cell proliferation by inducing necroptosis.
Factors Affecting Indoor Air against the Transmission Risk of Coronavirus Disease 2019: Systematic Review and Policy Analysis

BACKGROUND:Coronavirus disease 2019 (COVID-19) is thought to be transmitted primarily through droplets and contaminated surfaces through aerosols. AIM: Therefore, this study aims to identify the risk of COVID-19 agents in aerosol form and how indoor air control technique plays a role in the risk of disease transmission. It also examines the existing policies as administrative controls in managing the risk of COVID-19 transmission through indoor air control techniques. METHODS: This is a systematic review and policy study carried out in line with the preferred reporting item for systematic review and meta-analysis guidelines using ProQuest, PubMed, ScienceDirect, and Scopus databases. Furthermore, the search strategy was carried out using keywords with the Boolean AND and OR operations, namely, “COVID-19 AND (Transmission OR Spread) AND (aerosol OR airborne OR microdroplet) AND (Indoor OR Indoor Air OR Ventilation). RESULTS: In the policy review, the analysis unit was obtained from the official websites of the Indonesian Government and World Health Organization in the form of regulations, recommendations, guidelines, or other protocols that regulate indoor activities during the pandemic. There is a risk of COVID-19 agents from aerosols in indoor air. Meanwhile, the control of indoor air techniques plays a role in reducing the risk of transmission through aerosols by (1) increasing the exchange of indoor with outdoor air, (2) using air purifiers, and (3) paying attention to the layout of ventilation devices, airflow direction and distribution, as well as the flow of clean and dirty air in a room. CONCLUSION: Based on the results, the existing policies are still minimal in preventing transmission risk through indoor aerosols; hence, policy development is needed.
Kernelized Locality Sensitive Hashing for Fast Image Landmark Association

Abstract : As the concept of war has evolved, navigation in urban environments where GPS may be degraded is increasingly becoming more important. Two existing solutions are vision-aided navigation and vision-based Simultaneous Localization and Mapping (SLAM). The problem, however, is that vision-based navigation techniques can require excessive amounts of memory and increased computational complexity resulting in a decrease in speed. This research focuses on techniques to improve such issues by speeding up and optimizing the data association process in vision-based SLAM. Specifically, this work studies the current methods that algorithms use to associate a current robot pose to that of one previously seen and introduce another method to the image mapping arena for comparison. The current method, kd-trees, is effcient in lower dimensions, but does not narrow the search space enough in higher dimensional datasets. In this research, Kernelized Locality-Sensitive Hashing (KLSH) is implemented to conduct the aforementioned pose associations. Results on KLSH shows that fewer image comparisons are required for location identification than that of other methods. This work can then be extended into a vision-SLAM implementation to subsequently produce a map.
Effects of Salinity on Fertilization, Hatching, and Larval Performance of Longfin Smelt Spirinchus thaleichthys

Understanding the spawning and rearing habitats of fishes is critical to effective fisheries management and conservation. Longfin smelt Spirinchus thaleichthys is an imperiled migratory fish that is believed to spawn and rear in habitats of varying salinities; however, optimal conditions for each stage remain unknown. Here, we examined the effects of variation in salinity on egg fertilization, hatch success, and larval growth and survival. Eggs that were fertilized in freshwater (0.4 ppt) exhibited a significantly higher fertilization rate (81%) than those fertilized in brackish water (62% at 5 ppt), with no detectible effects of fish origin or female size. In contrast to fertilization rates, once the eggs were fertilized, their hatching rates were not affected by the fertilization salinity, incubation salinity, nor their interaction; however, hatching success and larval survival both increased with increasing maternal body mass. Larval growth rate appeared to be independent of salinity and maternal size. Taken together, the results indicate that fertilization is possible at a range of salinities, but optimal at lower salinities for longfin smelt; however, embryos and larvae can perform well across a range of salinities. Furthermore, results indicated that larger mothers produced high-quality offspring, a finding that supports the “bigger is better” paradigm in fisheries science and management. These results likely explain, in part, the spawning and rearing behaviors of wild longfin smelt and suggest that the conservation culture program would likely be optimized by utilizing freshwater fertilization and larger females as broodstock.
Broadband phonon-polariton dispersion relation of ferroelectric LiTaO3 crystals

Abstract Lithium tantalate is a well-known optical crystal. The dispersion relation of phonon-polaritons was studied in ferroelectric lithium tantalate crystals. The reflectivity spectra of E//x and E//z polarizations, which are related to E(x,y) and A1(z) symmetry modes respectively, were measured by the FT-IR measurement in the far- and mid-IR regions. The dispersion relation of phonon-polariton frequency against real and imaginary parts of polariton wavevector was determined. E(x,y) and A1(z) symmetry polariton modes were also studied by forward Raman scattering. By the combination with the observed polariton dispersion relation determined by forward Raman scattering and terahertz time-domain spectroscopy, the broadband polariton frequency dispersion was determined between 10 cm−1 and 1200 cm−1.