Miracle-dz/UniFAR-FTUs huggingface dataset:
Ultra-high-resolution observations of the intrinsic line profiles of interstellar CH, CH+ and CN

Ultra-high-resolution (0.3 km s–1 FWHM) observations of interstellar CH and CH+ are presented for five southern stars (HD 110432, 152234, 152235, 152236 and 152270); CN spectra were also obtained for HD 152236 and 152270, and Ca K and K I spectra for HD 110432. These observations have enabled us to resolve the intrinsic line profiles towards these stars for the first time, and have made possible the accurate measurement of the velocity dispersions (b-values) of the various atomic and molecular velocity components. The line profiles are found to be inconsistent with shock theories for the production of CH+ in diffuse molecular clouds, and favour the view that this molecule is produced in warm (T ≳ 2000 K) gas at the interfaces between cool dense clouds and the hot interior of the Sco-Cen bubble. In the case of one star (HD 152270) the b-value measurements conclusively demonstrate an onion-shell-like structure for the absorbing cloud, with CN occurring in the coolest/least turbulent region (presumably the deep interior), CH in a somewhat hotter/more turbulent region (presumably the outer regions), and CH+ in the warmest/most turbulent region of all (as expected for an interface with a hot inter cloud medium.
LncRNA TP73-AS1 Exacerbates the Non-Small-Cell Lung Cancer (NSCLC) Process via Regulating miR-125a-3p-Mediated ACTN4

Background LncRNA TP73-AS1 has been revealed to exert a noteworthy impact on the occurrence and advancement of different cancers. In this study, we explored the function of TP73-AS1 in tumor growth, cell progression as well as the relevant molecular mechanism in non-small-cell lung cancer (NSCLC). Methods QRT-PCR was employed to assess the expression of TP73-AS1, miR‐125a-3p, and actinin alpha 4 (ACTN4) in NSCLC cells. The biological effect of TP73-AS1 on NSCLC cells was assessed by cell transfection, CCK8, and transwell experiments. We further predicted the interaction among RNAs (TP73-AS1, miR-125a-3p, and ACTN4) through bioinformatics online tools and verified via luciferase reporter, RNA immunoprecipitation, and qRT-PCR assays. Xenograft models of SPC-A1 cells were conducted to test how TP73-AS1 regulates tumorigenesis. Western blot, as well as the immunohistochemistry (IHC) assays, was utilized to measure the expression levels. Functions of TP73-AS1 in NSCLC progression through the miR-125a-3p/ACTN4 axis were investigated by rescue experiments. Results Knockdown of TP73-AS1 suppressed the growth and simultaneously attenuated the migration and invasion ability of NSCLC SPC-A1 and A549 cells. Bioinformatics and molecular mechanism assays demonstrated that TP73-AS1 could bind to miR-125a-3p/ACTN4 and regulate their expression. Moreover, the rescued‐function experiment demonstrated that suppressing miR-125a-3p or elevating ACTN4 turned around the suppression effect of sh-TP73-AS1 on NSCLC progression. TP73-AS1 inhibition could also inhibit the NSCLC tumor growth and correspondingly regulated the expression of miR-125a-3p and ACTN4 in the tumor xenograft model. Conclusion The present study indicated that TP73-AS1 affects NSCLC progression through a new competitive RNA (ceRNA) regulatory network of miR-125a-3p/ACTN4, providing an underlying target for NSCLC treatment in the future.
The Neural Multilineage Differentiation Capacity of Human Neural Precursors from the Umbilical Cord—Ready to Bench for Clinical Trials

Mesenchymal stem cells (MSC) are promising for regenerative medicine as they have a vast differentiation capacity, immunomodulatory properties and can be isolated from different tissues. Among them, the umbilical cord is considered a good source of MSC, as its collection poses no risk to donors and is unrelated to ethical issues. Furthermore, umbilical cord mesenchymal stem cells (UC-MSC) can differentiate into several cell lines, including neural lineages that, in the future, may become an alternative in the treatment of neurodegenerative diseases. This study used a natural functional biopolymer matrix (NFBX) as a membrane to differentiate UC-MSC into neurospheres and their Neural precursors without using neurogenic growth factors or gene transfection. Through the characterization of Neural precursors and differentiated cells, it was possible to demonstrate the broad potential for the differentiation of cells obtained through cultivation on this membrane. To demonstrate these Neural precursors’ potential for future studies in neurodegenerative diseases, the Neural precursors from Wharton’s jelly were differentiated into Schwann cells, oligodendrocytes, cholinergic-, dopaminergic- and GABAergic-like neurons.
A Peptide HEPFYGNEGALR from Apostichopus japonicus Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J Mice

Liver-related disease caused by alcohol is a frequent disorder of the hepatic tract. Heavy consumption of alcohol in a short period causes oxidative damage to the liver. Sea cucumber is abundant in nutrients and its various extracts have been studied for antioxidant properties. One peptide was isolated and identified from Apostichopus japonicus in our recent study. We investigated the benefits of the peptide in a model of acute ethanol-induced male C57BL/6J mice. Dietary intake of the peptide could attenuate hepatomegaly, hepatitis and the accumulation of lipid droplets, and increase antioxidant enzyme activities in mice with acute alcoholic liver injury. The results indicated that a 20 mg/kg peptide supplement could activate the Nrf2/HO-1 pathway and block the nuclear translocation of NF-κB to alleviate oxidative stress and inflammation. In addition, the preventive effects of peptide supplementation may be related to autophagy. This study suggests that dietary supplementation with a sea cucumber-derived peptide is one of the potential candidates to alleviate acute alcoholic liver injury.
Government controlling ownership and CEO compensation incentives: evidence from China

ABSTRACT This paper investigates the relationship between government-controlling ownership and CEO compensation incentives in China, using a comprehensive evaluation of CEO pay-performance sensitivity (PPS). We find that government-controlling ownership weakens CEO PPS, with PPS being around 6 lower for CEOs in state-owned enterprises (SOEs) than CEOs in non-state-owned enterprises (non-SOEs), representing a reduction of around 14% for a CEO with the average level of PPS. The results sustain after using privatization as the experiment setting wherein firms’ ultimate controllers changed from government owners to private owners. Moreover, the negative influence of government controlling ownership on CEO compensation incentives is more prominent in SOEs with a higher level of government ownership or a lower hierarchy government as the controller. We also explore the association between CEO incentives and firm performance and find that PPS in SOEs is more important in association with firms’ stock performance than non-SOEs. Results in this paper extend studies on the influence of government controlling ownership on CEO compensation incentives, an issue that is caught much attention in the ongoing reform of China’s SOEs.
Determinants of Tomato Farmers Participation in Agricultural Services and Training Centre (ASTC) Activities

Agricultural production have remained rudimentary despite many years’ of technology development and transfer; to reverse this declining trend, several agricultural policies and programmes aimed at ensuring sustainable production, improved income and farm expansion with added value output have become very germane. This study therefore analyzed tomato farmers’ participation in ASTC activities in Jos-south local Government Area of Plateau state, Nigeria. This study adopted multi stage sampling techniques. Primary was data collected from 80 respondents, during the 2017/2018 farming season and were analyzed using descriptive statistics, participation index, weighted average index analysis and Binary Logit regression. The result of the study revealed that 73.8% were male; 88.75% had access to extension contact. The estimated mean for educational training, household size, farm income and farming experience were 6 years; 8 people; ₦108,500/ha and 12 years respectively. Also, most (68.7%) of the farmers have low participation index of ≤0.45; this trend is responsible for the existing low farm productivity of this crop in the area. Furthermore, the benefits derived from participating in ASTC activities among the respondents were significant as indicated by their weighted average index. In addition, the estimated coefficient of multiple determination (R2) was 0.7602. Also, the coefficients of household size (0.421), education (0.559), experience (0.808), income (0.485) and extension contact (0.376) were statistically significant; implying that these factors in the regression model affected the likelihood of farmer’s decision to participate in ASTC activities. Adequate labour supply; establishment of pilot farms; capacity training; access to agricultural credit, extension services, agro service centres, agricultural information, input supply and cooperative formation are strongly recommended.
The Role of Fine Needle Aspiration of Liver and Spleen in the Staging of Low-Grade Canine Cutaneous Mast Cell Tumor

Simple Summary Mast cell tumor is one of the most common cutaneous tumors in dogs, representing 16–21% of all cutaneous tumors. Clinical staging is a fundamental step in the patients’ assessment, and it is considered essential to further refine the prognosis and to establish an ad hoc therapeutic plan. The recommended staging work-up includes a basic laboratory database, fine needle aspiration of the expected tumor draining lymph node/s, and diagnostic imaging with fine needle aspiration of the liver and spleen. The aim of this retrospective study was to investigate the incidence, at presentation, of hepatic and splenic metastases in dogs affected by low-grade cutaneous mast cell tumor referred for further investigations (Patnaik grade I–II, Kiupel low-grade). Only 1 out of 136 dogs had the presence of visceral metastases at diagnosis, suggesting that the prevalence of visceral metastases in low-grade cutaneous mast cell tumor is extremely low and that cytology of visceral organs may not represent an essential step in the clinical staging work-up in these dogs. Abstract Clinical staging is a fundamental step in the clinical assessment of canine cutaneous mast cell tumor (cMCT), and it is recommended to evaluate the tumor draining lymph node (eTDLN), perform diagnostic imaging, and fine needle aspiration (FNA) of the spleen and liver to determine the presence of metastatic disease, thereby refining the prognosis. The aim of this retrospective study was to evaluate the prevalence of splenic and hepatic involvement in newly diagnosed canine low-grade cMCT (Patnaik grade I–II, Kiupel low-grade). Medical records of dogs that underwent a clinical staging work-up and surgical excision for a low-grade cMCT between December 2019 and December 2021 were reviewed at five veterinary centers. Only dogs with a histological diagnosis of low-grade cMCT, FNA or histology of the eTDLN, FNA of the spleen and liver, and one year of follow up were included. One hundred and thirty-six dogs met the inclusion criteria. Only 1 out of 136 dogs (0.7%) had the presence of visceral metastases at diagnosis, suggesting that the prevalence of visceral metastases in low-grade cMCT is extremely low. The results of this study are consistent with previous literature and suggest that after a diagnosis of low-grade cMCT, cytology of visceral organs may not represent an essential step in the clinical staging work-up.
Parents’ Competencies and Involvement in Facilitating Modular Instructions: Its Relation to Students’ Personality Development

This study assessed the parents’ competency, involvement in modular instructions, the implementation of distance learning modality, and its relationship to the healthy development of the students. The study utilized a descriptive- correlation design with 280 grade six students from a public elementary school in the Schools Division of Quezon for the School Year 2021-2022. The samples were mostly children of married, high school graduate parents and majority were twelve-year old female students. The results showed that the parents are ‘much competent’ in facilitating modular instructions in terms of knowledge, attitudes, and practices. Meanwhile, the parents are ‘very often’ involved in facilitating modular instructions in terms of school work support, financial support, and moral support. On the other hand, the intermediate students agree on the level of personality development in terms of motivation, self-esteem, and self-reliance, signifying positive effects of parental involvement on students’ personality development. Furthermore, there is a very strong significant positive relationship between the parental competencies and involvement and the personality development interpreted of the students. The results imply on the importance of parental involvement in the personality development of the children specially during the absence of face to face classes.
Evaluating the Typical Day-to-Day Variability of WHOOP-Derived Heart Rate Variability in Olympic Water Polo Athletes

Heart rate (HR) and HR variability (HRV) can be used to infer readiness to perform exercise in athletic populations. Advancements in the photoplethysmography technology of wearable devices such as WHOOP allow for the frequent and convenient measurement of HR and HRV, and therefore enhanced application in athletes. However, it is important that the reliability of such technology is acceptable prior to its application in practical settings. Eleven elite male water polo players (age 28.8 ± 5.3 years [mean ± standard deviation]; height 190.3 ± 3.8 cm; body mass 95.0 ± 6.9 kg; international matches 117.9 ± 92.1) collected their HR and HRV daily via a WHOOP strap (WHOOP 3.0, CB Rank, Boston, MA, USA) over 16 weeks ahead of the 2021 Tokyo Olympic Games. The WHOOP strap quantified HR and HRV via wrist-based photoplethysmography during overnight sleep periods. The weekly (i.e., 7-day) coefficient of variation in lnRMSSD (lnRMSSDCV) and HR (HRCV) was calculated as a measure of day-to-day variability in lnRMSSD and HR, and presented as a mean of the entire recording period. The mean weekly lnRMSSDCV and HRCV over the 16-week period was 5.4 ± 0.7% (mean ± 95% confidence intervals) and 7.6 ± 1.3%, respectively. The day-to-day variability in WHOOP-derived lnRMSSD and HR is within or below the range of day-to-day variability in alternative lnRMSSD (~3–13%) and HR (~10–11%) assessment protocols, indicating that the assessment of HR and HRV by WHOOP does not introduce any more variability than that which is naturally present in these variables.
The Pomeron contribution to p p and p anti-p scattering in AdS/QCD

We consider the differential and total cross sections for proton-proton and proton-antiproton scattering in the Regge regime from the point of view of string dual models of QCD. We argue that the form factor which appears in the differential cross section is related to the matrix element of the stress tensor between proton states and give a procedure for computing the strength of the coupling of the Pomeron trajectory to the proton. We compute this coupling in the Sakai-Sugimoto model and find excellent agreement with the data at large s and small t. The form factor can be estimated in the Skyrme model or in AdS/QCD models and gives a stiffer form factor than the commonly used electromagnetic form factor, in agreement with our fits to data. Our model is also in good agreement with the measured ratio of real to imaginary parts of the forward scattering amplitude at large s.
Retrospective Study for the Clinical Evaluation of a Real-Time PCR Assay with Lyophilized and Ready-to-Use Reagents for Streptococcus agalactiae Detection in Prenatal Screening Specimens

Streptococcus agalactiae is a leading cause of sepsis and meningitis in newborns and young infants. Screening programs and intrapartum antibiotic prophylaxis have reduced early neonatal onset of disease. The aim of this study was to evaluate a molecular assay with lyophilized and ready-to-use reagents: VIASURE® Streptococcus B Real Time PCR detection kit (CerTest Biotec) (Viasure qPCR assay) compared to both the GBS culture and a molecular assay with separated and frozen reagents: Strep B Real-TM Quant (Sacace Biotecnologies®) (Sacace qPCR assay). A total of 413 vaginal–rectal swabs from women between the 35th and 37th weeks of pregnancy were processed. GBS culture was firstly achieved through Granada medium and Columbia CNA agar at 35 °C in aerobic conditions. Then, nucleic acid extraction was performed for subsequent molecular analysis using both commercial assays. Discordant results were resolved via bidirectional Sanger sequencing. Viasure qPCR assay clinical sensitivity was 0.97 (0.92–0.99) and specificity 1 (0.98–1). This retrospective study demonstrated the good clinical parameters and the strong overall agreement (99.3%) between the Viasure qPCR assay and both reference assays. Finally, the added value observed of the assay under study was the stabilized and ready-to-use format, reducing the number of time-consuming steps, permitting the storage at room temperature, facilitating transport, being environmentally respectful, and reducing additional costs.
Clustering: A Data Recovery Approach

What Is Clustering Key Concepts Case Study Problems Bird's-Eye View What Is Data Key Concepts Feature Characteristics Bivariate Analysis Feature Space and Data Scatter Pre-Processing and Standardizing Mixed Data Similarity Data K-Means Clustering and Related Approaches Key Concepts Conventional K-Means Choice of K and Initialization of K-Means Intelligent K-Means: Iterated Anomalous Pattern Minkowski Metric K-Means and Feature Weighting Extensions of K-Means Clustering Overall Assessment Least-Squares Hierarchical Clustering Key Concepts Hierarchical Cluster Structures Agglomeration: Ward Algorithm Least-Squares Divisive Clustering Conceptual Clustering Extensions of Ward Clustering Overall Assessment Similarity Clustering: Uniform, Modularity, Additive, Spectral, Consensus and Single Linkage Key Concepts Summary Similarity Clustering Normalized Cut and Spectral Clustering Additive Clustering Consensus Clustering Single Linkage, Minimum Spanning Tree and Connected Components Overall Assessment Validation and Interpretation Key Concepts General: Internal and External Validity Testing Internal Validity Interpretation Aids in the Data Recovery Perspective Conceptual Description of Clusters Mapping Clusters to Knowledge Overall Assessment Least-Squares Data Recovery Clustering Models Key Concepts Statistics Modelling as Data Recovery K-Means as a Data Recovery Method Data Recovery Models for Hierarchical Clustering Data Recovery Models for Similarity Clustering Consensus and Ensemble Clustering Overall Assessment References Index
On the locally self-similar singular solutions for the incompressible Euler equations

In this paper we consider the locally backward self-similar solutions for the Euler system, and focus on the case that the possible nontrivial velocity profiles have non-decaying asymptotics. We derive the meaningful representation formula of the pressure profile in terms of velocity profiles in this case, and by using it and the local energy inequality of profiles, we prove some nonexistence results and show the energy behavior concerning the possible velocity profiles.
Transport Equation and Tomography

Main designations introduction direct and inverse problems for the transport equation with energy dependence derivation of the radiation transport equation formulation and investigation of the direct problem for the transport equation continuity of solutions to the direct problem determination of the total attenuation coefficient for discontinuous density of the input flux description of a source with discontinuous radiation density a boundary value problem with a parameter for the transport equation determining the total interaction coefficient by multiple irradiation providing special boundary conditions for multiple irradiation testing the algorithms for determining unknown media the tomography problem in the monoenergetic case the direct problem for the monoenergetic transport equation additional restrictions a formula for the gradient of a solution to the transport equation auxiliary statements the indicator of heterogeneity in the tomography problem, and the measure of visibility invisibility media in tomography computerized testing of the indicator of heterogeneity some contradictions between two mathematical models of transport theory comparing two models in transport theory in the plane-parallel case prospective investigation.
Pigmented Fungiform Papillae (PFP) of the Tongue: A Systematic Review of Current Aetiopathogenesis and Pathophysiology

The pigmentation of the fungiform papillae of the tongue is a rare idiopathic condition in which only the fungiform papillae appear hyperpigmented. In the absence of any reviews on the subject, we conducted a systematic review of the aetiopathogenesis and pathophysiology of pigmented fungiform papillae (PFP) of the tongue, including its demographic and histopathological features, trying to outline a possible aetiology. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) was performed using PubMed, Scopus, EMBASE databases and manual searches, for publications between January 1974 and July 2022. Inclusion criteria were case reports defining patients’ characteristics, their general medical and dental conditions, histopathological and/or immunohistochemical findings, all with a final definitive diagnosis of PFP. Overall, 51 studies comprising 69 cases of PFP which included histopathological descriptions were reviewed. Prominent features consisted of hyperpigmentation of melanocytes, melanophages, chromatophores, and a lymphocytic infiltrate in the subepidermal area of the fungiform papillae. On special staining, PFP contained melanin, not iron or hemosiderin. On immunohistochemistry, immune-reactive CD3+ T lymphocytes, S-100 and Sox10, but non-immune-reactive melan-A intraepithelial melanocytes were noted in some studies. The presence of hyperpigmented melanocytes and melanophages, with non-immune-reactive melan-A, suggests that PFP are a benign and physiological form of pigmentation. The inflammatory infiltrates described in some papillary lesions could possibly be due to traumatic events during mastication. Nevertheless, the true reasons for the hyperpigmentation of the fungiform papillae are as of yet elusive, and remain to be determined.
Introduction to non-Kerr Law Optical Solitons

INTRODUCTION History Optical Waveguides THE NONLINEAR SCHRODINGER EQUATION Introduction Traveling Waves Integrals of Motion Parameter Evolution Quasi-Stationary Solution KERR LAW NONLINEARITY Introduction Traveling Wave Solution Inverse Scattering Transform Integrals of Motion Variational Principle Quasi-Stationary Solution Lie Transform POWER LAW NONLINEARITY Introduction Traveling Wave Solution Integrals of Motion Quasi-Stationary Solution PARABOLIC LAW NONLINEARITY Introduction Traveling Wave Solution Integrals of Motion Quasi-Stationary Solution DUAL-POWER LAW NONLINEARITY Introduction Traveling Wave Solution Integrals of Motion Quasi-Stationary Solution SATURABLE LAW NONLINEARITY Introduction The NLSE Bistable Solitons Arbitrary Pulse Propagation SOLITON-SOLITON INTERACTION Introduction Mathematical Formulation Quasi-Particle Theory STOCHASTIC PERTURBATION Introduction Kerr Law Power Law Parabolic Law Dual-Power Law OPTICAL COUPLERS Introduction Twin-Core Couplers Multiple-Core Couplers Magneto-Optic Waveguides OPTICAL BULLETS Introduction 1 + 3 Dimensions EPILOGUE HINTS AND SOLUTIONS BIBLIOGRAPHY INDEX