Miracle-dz/UniFAR-FTUs huggingface dataset:
A survey of interstellar molecular hydrogen. I

The Copernicus ultraviolet telecope was used to survey the column densities of interstellar H/sub 2/ in the J=0 and 1 rotational levels of the v''=0 vibrational state toward 109 stars, including 26 measurements collected from previous publications. In most cases, the H/sub 2/ lines exhibit strong damping wings; and column densities are derived by fitting damping profiles to the observed spectra. For stars with strong H/sub 2/ lines, most of the interstellar H/sub 2/ is in the two lowest rotational levels; and N (0)+N (1) is a good measure of N (H/sub 2/), the total H/sub 2/ column density. When f=2N (H/sub 2/)/(2N (H/sub 2/)+N (H I)) is correlated with E (B-V) and with N (H I+H/sub 2/), the total hydorgen column density, it is found that f undergoes a transition from low values ( 0.01) when E (B-V) approx. =0.08 and N (H I+H/sub 2/) approx. =5 x 10/sup 20/ atoms cm/sup -2/. For E (B-V) or =0.15, 74% have f> or =0.1. The correlations of f with E (B-V) or N (H I+H/sub 2/) show a peak-to-peak spread of about a factormore » of 10 in the values of f. For stars with E (B-V) > or =0.1, the smaller than normal values of f are often associated with objects which have a larger than normal gas-to color excess ratio. The observed trends are consistent with recent theoretical calculations of J. Black involving a balance between the efficient formation of H/sub 2/ on interstellar grains and the destruction of H/sub 2/ through a two-step photodissociation process in clouds with total densities ranging from about 10 to 500 atoms cm/sup -3/. A group of five stars with middle B spectral types and with small E (B-V) exhibit abnormally large values of N (H/sub 2/). Three of these stars also have unusually strong CH/sup +/ lines, possibly suggesting a common circumstellar origin for the two molecules. The survey measurements provide the following overall averages: =. sigma.N (H/sub 2/)/. sigma.r=0.036 cm/sup -3/,« less
Effects of Conditioned Medium of Adipose-Derived Stem Cells Exposed to Platelet-Rich Plasma on the Expression of Endothelial Nitric Oxide Synthase and Angiogenesis by Endothelial Cells

Abstract Platelet-rich plasma (PRP) and adipose-derived stem cells (ADSCs) are known to secrete angiogenic factors that contribute to the treatment of intractable ulcers. The combination of PRP and ADSCs may enhance their angiogenic effects. However, it remains unclear whether treatment of ADSCs with PRP influences angiogenesis. We studied whether the conditioned medium from PRP-treated ADSCs under hypoxic conditions exerts angiogenic effects. Although PRP stimulated the proliferation of ADSCs obtained from rats, it decreased the mRNA levels of vascular endothelial growth factor, hepatocyte growth factor, and TGF-β1, but not of basic fibroblast growth factor, under hypoxia. The conditioned medium of PRP-treated ADSCs inhibited endothelial nitric oxide synthase phosphorylation, decreased NO production, and suppressed tube formation in human umbilical vein endothelial cells. Transplantation of ADSCs alone increased both blood flow and capillary density of the ischemic limb; however, its combination with PRP did not further improve blood flow or capillary density. This suggests that both conditioned medium of ADSCs treated with PRP and combination of PRP with ADSCs transplantation may attenuate the phosphorylation of endothelial nitric oxide synthase and angiogenesis.
Psychophysical evidence for the involvement of head/body-centered reference frames in egocentric visuospatial memory: A whole-body roll tilt paradigm

Accurate memory regarding the location of an object with respect to one's own body, termed egocentric visuospatial memory, is essential for action directed toward the object. Although researchers have suggested that the brain stores information related to egocentric visuospatial memory not only in the eye-centered reference frame but also in the other egocentric (i.e., head- or body-centered or both) reference frames, experimental evidence is scarce. Here, we tested this possibility by exploiting the perceptual distortion of head/body-centered coordinates via whole-body tilt relative to gravity. We hypothesized that if the head/body-centered reference frames are involved in storing the egocentric representation of a target in memory, then reproduction would be affected by this perceptual distortion. In two experiments, we asked participants to reproduce the remembered location of a visual target relative to their head/body. Using intervening whole-body roll rotations, we manipulated the initial (target presentation) and final (reproduction of the remembered location) body orientations in space and evaluated the effect on the reproduced location. Our results showed significant biases of the reproduced target location and perceived head/body longitudinal axis in the direction of the intervening body rotation. Importantly, the amount of error was correlated across participants. These results provide experimental evidence for the neural encoding and storage of information related to egocentric visuospatial memory in the head/body-centered reference frames.
Assessing the bias of maximum likelihood estimates of contaminated garch models

It is well known that Gaussian maximum likelihood estimates of time series models are not robust. In this paper we prove this is also the case for the Generalized Autoregressive Conditional Heteroscedastic (GARCH) models. By expressing the Gaussian maximum likelihood estimates as Ψ estimates and by assuming the existence of a contaminated process, we prove they possess zero breakdown point and unbounded influence curves. By simulating GARCH processes under several proportions of contaminations we assess how much biased the maximum likelihood estimates may become and compare these results to a robust alternative. The t-student maximum likelihood estimates of GARCH models are also considered.
The psychosocial adjustment of kidney recipients across donation contexts

The objective of this study was to investigate kidney recipients’ experiences within deceased and living donation contexts and, in the latter, by donor relationship type, to identify differences by context and mechanisms by which the relationship with the donor may impact recipients’ psychosocial well-being. Individual interviews were conducted with 12 participants and analyzed using Interpretative Phenomenological Analysis. Three themes emerged: (a) salience of and sensitivity toward sacrifice and loss, (b) honoring the sacrifice by honoring the gift, and (c) relational imbalance mirroring perceived burden of donation. Findings were contextualized in relation to the transplantation literature, and their clinical implications discussed.
The Case for a Novel Therapeutic Approach to Dementia: Small Molecule Hepatocyte Growth Factor (HGF/MET) Positive Modulators

An estimated 6.5 million Americans aged 65 years or older have Alzheimer’s disease (AD), which will grow to 13.8 million Americans by 2060. Despite the growing burden of dementia, no fundamental change in drug development for AD has been seen in > 20 years. Currently approved drugs for AD produce only modest symptomatic improvements in cognition with small effect sizes. A growing mismatch exists between the urgent need to develop effective drugs for symptomatic AD and the largely failed search for disease modification. The failure rate of clinical trials in AD is high overall, and in particular for disease-modifying therapies. Research efforts in AD have focused predominantly on amyloid-β and tau pathologies, but limiting clinical research to these “classical hallmarks” of the disease does not address the most urgent patient, caregiver, or societal needs. Rather, clinical research should consider the complex pathophysiology of AD. Innovative approaches are needed that provide outside-the-box thinking, and re-imagine trial design, interventions, and outcomes as well as progress in proteomics and fluid biomarker analytics for both diagnostics and disease monitoring. A new approach offering a highly specific, yet multi-pronged intervention that exerts positive modulation on the HGF/MET neurotrophic system is currently being tested in mid-to-late-stage clinical trials in mild to moderate AD. Findings from such trials may provide data to support novel approaches for development of innovative drugs for treating AD at various disease stages, including among patients already symptomatic, and may offer benefits for other neurodegenerative diseases.
Superior Laryngeal Nerve Block Response Rates in 54 Neurogenic Cough Patients

Neurogenic cough related to hypersensitivity of the internal branch of the superior laryngeal nerve (SLN) is often treated with neuromodulating medications, which can cause considerable side effects. An alternative therapy is steroid and local anesthetic injection of the SLN (“SLN block”), initially proposed to benefit those with lateralizing symptoms (tenderness over the thyrohyoid membrane or unilateral cough source). Our objectives are to determine if SLN block produces subjective symptomatic improvements and if repeat injections further improve symptoms, and evaluate clinical factors potentially predictive of response.
A Zinc Finger Motif in the P1 N Terminus, Highly Conserved in a Subset of Potyviruses, Is Associated with the Host Range and Fitness of Telosma Mosaic Virus

Viruses belonging to the family Potyviridae represent the largest group of plant-infecting RNA viruses, including a variety of agriculturally and economically important viral pathogens. Like all picorna-like viruses, potyvirids employ polyprotein processing as the gene expression strategy. ABSTRACT P1 is the first protein translated from the genomes of most viruses in the family Potyviridae, and it contains a C-terminal serine-protease domain that cis-cleaves the junction between P1 and HCPro in most cases. Intriguingly, P1 is the most divergent among all mature viral factors, and its roles during viral infection are still far from understood. In this study, we found that telosma mosaic virus (TelMV, genus Potyvirus) in passion fruit, unlike TelMV isolates present in other hosts, has two stretches at the P1 N terminus, named N1 and N2, with N1 harboring a Zn finger motif. Further analysis revealed that at least 14 different potyviruses, mostly belonging to the bean common mosaic virus subgroup, encode a domain equivalent to N1. Using the newly developed TelMV infectious cDNA clones from passion fruit, we demonstrated that N1, but not N2, is crucial for viral infection in both Nicotiana benthamiana and passion fruit. The regulatory effects of N1 domain on P1 cis cleavage, as well as the accumulation and RNA silencing suppression (RSS) activity of its cognate HCPro, were comprehensively investigated. We found that N1 deletion decreases HCPro abundance at the posttranslational level, likely by impairing P1 cis cleavage, thus reducing HCPro-mediated RSS activity. Remarkably, disruption of the Zn finger motif in N1 did not impair P1 cis cleavage and HCPro accumulation but severely debilitated TelMV fitness. Therefore, our results suggest that the Zn finger motif in P1s plays a critical role in viral infection that is independent of P1 protease activity and self-release, as well as HCPro accumulation and silencing suppression. IMPORTANCE Viruses belonging to the family Potyviridae represent the largest group of plant-infecting RNA viruses, including a variety of agriculturally and economically important viral pathogens. Like all picorna-like viruses, potyvirids employ polyprotein processing as the gene expression strategy. P1, the first protein translated from most potyvirid genomes, is the most variable viral factor and has attracted great scientific interest. Here, we defined a Zn finger motif-encompassing domain (N1) at the N terminus of P1 among diverse potyviruses phylogenetically related to bean common mosaic virus. Using TelMV as a model virus, we demonstrated that the N1 domain is key for viral infection, as it is involved both in regulating the abundance of its cognate HCPro and in an as-yet-undefined key function unrelated to protease processing and RNA silencing suppression. These results advance our knowledge of the hypervariable potyvirid P1s and highlight the importance for infection of a previously unstudied Zn finger domain at the P1 N terminus.
Strain-order coupling in nematic elastomers: Equilibrium configurations

We consider models that describe liquid crystal elastomers either in a biaxial or in a uniaxial phase and in the framework of Frank's director theory. We prove the existence of static equilibrium solutions in the presence of frustrations due to electro-mechanical boundary conditions and to applied loads and fields. We find explicit solutions arising in connection with special boundary conditions and the corresponding phase diagrams, leading to significant implications on possible experimental observations.
Matrix Differential Calculus with Applications

Preface MATRICES: Basic Properties of Vectors and Matrices Kronecker Products, the Vec-Operator and the Moore- Penrose Inverse Miscellaneous Matrix Results DIFFERENTIALS: THE THEORY: Mathematical Preliminaries Differentials and Differentiability The Second Differential Static Optimization DIFFERENTIALS: THE PRACTICE: Some Important Differentials First- Order Differentials and Jacobian Matrices Second-Order Differentials and Hessian Matrices INEQUALITIES: Inequalities THE LINEAR MODEL: Statistical Preliminaries The Linear Regression Model Further Topics in the Linear Model APPLICATIONS TO MAXIMUM LIKELIHOOD ESTIMATION: Maximum Likelihood Estimation Simultaneous Equations Topics in Psychometrics Subject Index Bibliography.
Left atrial appendage closure in end‐stage renal disease and hemodialysis: Data from a German multicenter registry

Left atrial appendage closure (LAAC) has emerged as an alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF). OAC treatment has been proven feasible in mild‐to‐moderate chronic kidney disease (CKD). In contrast, the optimal antithrombotic management of AF patients with end‐stage renal disease (ESRD) is unknown and LAAC has not been proven in these patients in prospective randomized clinical trials.
Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study

Abstract Background People with human immunodeficiency virus (HIV; PWH) have increased cardiovascular risk. Higher leukocyte count has been associated with coronary artery disease (CAD) events in the general population. It is unknown whether the leukocyte-CAD association also applies to PWH. Methods In a case-control study nested within the Swiss HIV Cohort Study, we obtained uni- and multivariable odds ratios (OR) for CAD events, based on traditional and HIV-related CAD risk factors, leukocyte count, and confounders previously associated with leukocyte count. Results We included 536 cases with a first CAD event (2000–2021; median age, 56 years; 87% male; 84% with suppressed HIV RNA) and 1464 event-free controls. Cases had higher latest leukocyte count before CAD event than controls (median [interquartile range], 6495 [5300–7995] vs 5900 [4910–7200]; P < .01), but leukocytosis (>11 000/µL) was uncommon (4.3% vs 2.1%; P = .01). In the highest versus lowest leukocyte quintile at latest time point before CAD event, participants had univariable CAD-OR = 2.27 (95% confidence interval, 1.63–3.15) and multivariable adjusted CAD-OR = 1.59 (1.09–2.30). For comparison, univariable CAD-OR for dyslipidemia, diabetes, and recent abacavir exposure were 1.58 (1.29–1.93), 2.19 (1.59–3.03), and 1.73 (1.37–2.17), respectively. Smoking and, to a lesser degree, alcohol and ethnicity attenuated the leukocyte-CAD association. Leukocytes measured up to 8 years before the event were significantly associated with CAD events. Conclusions PWH in Switzerland with higher leukocyte counts have an independently increased risk of CAD events, to a degree similar to traditional and HIV-related risk factors.
A uvbyCaHβ CCD Analysis of the Open Cluster Standard, M67, and Its Relation to NGC 752

Precision CCD uvbyCaHβ photometry is presented of the old cluster, M67, covering one square degree with typical internal precision at the 0.005–0.020 mag level to V ∼ 17. The photometry is calibrated using standards over a wide range in luminosity and temperature from NGC 752 and zeroed to the standard system via published photoelectric observations. Relative to NGC 752, differential offsets in reddening and metallicity are derived using astrometric members, supplemented by radial velocity information. From single-star members, offsets in the sense (M67−NGC 752) are δ E(b − y) = −0.005 ± 0.001 (sem) mag from 327 F/G dwarfs and δ[Fe/H] = 0.062 ± 0.006 (sem) dex from the combined m 1 and hk indices of 249 F dwarfs, leading to E(b − y) = 0.021 ± 0.004 (sem) and [Fe/H]M67 = +0.030 ± 0.016 (sem) assuming [Fe/H]Hyades = +0.12. With probable binaries eliminated using c 1, (b − y) indices, 83 members with (π/σ π ) > 50 generate (m − M)0 = 8.220 ± 0.005 (sem) for NGC 752 and an isochronal age of 1.45 ± 0.05 Gyr. Using the same parallax restriction for 312 stars, M67 has (m − M) = 9.77 ± 0.02 (sem), leading to an age tied solely to the luminosity of the subgiant branch of 3.70 ± 0.03 Gyr. The turnoff color spread implies ±0.1 Gyr, but the turnoff morphology defines a younger age/higher mass for the stars, consistent with recent binary analysis and broadband photometry indicating possible missing physics in the isochrones. Anomalous stars positioned blueward of the turnoff are discussed.
Cocycles de groupe pour $\GL_n$ et arrangements d'hyperplans

Many authors have constructed different, but related, linear group cocycles that are usually referred to as ``Eisenstein cocycles. '' The main goal of this work is to describe a topological construction that is a common source for all these cocycles. One interesting feature of this construction is that, starting from a purely topological class, it leads to the algebraic world of meromorphic forms on hyperplane complements in $n$-fold products of either the (complex) additive group, the multiplicative group or a (family of) elliptic curve(s). This yields the construction of three types of ``Sczech cocycles. ''
The Impact of Opioid Prescribing Limits on Drug Usage in South Carolina: A Novel Geospatial and Time Series Data Analysis

The opioid crisis in the United States has had devastating effects on communities across the country, leading many states to pass legislation that limits the prescription of opioid medications in an effort to reduce the number of overdose deaths. This study investigates the impact of South Carolina’s prescription limit law (S.C. Code Ann. 44-53-360), which aims to reduce opioid overdose deaths, on opioid prescription rates. The study utilizes South Carolina Reporting and Identification Prescription Tracking System (SCRIPTS) data and proposes a distance classification system to group records based on proximity and evaluates prescription volumes in each distance class. Prescription volumes were found to be highest in classes with pharmacies located further away from the patient. An Interrupted Time Series (ITS) model is utilized to assess the policy impact, with benzodiazepine prescriptions as a control group. The ITS models indicate an overall decrease in prescription volume, but with varying impacts across the different distance classes. While the policy effectively reduced opioid prescription volumes overall, an unintended consequence was observed as prescription volume increased in areas where prescribers were located at far distances from patients, highlighting the limitations of state-level policies on doctors. These findings contribute to the understanding of the effects of prescription limit laws on opioid prescription rates and the importance of considering location and distance in policy design and implementation.
Optimising complexity of CNN models for resource constrained devices: QRS detection case study

Traditional DL models are complex and resource hungry and thus, care needs to be taken in designing Internet of (medical) things (IoT, or IoMT) applications balancing efficiency-complexity trade-off. Recent IoT solutions tend to avoid using deep-learning methods due to such complexities, and rather classical filter-based methods are commonly used. We hypothesize that a shallow CNN model can offer satisfactory level of performance in combination by leveraging other essential solution-components, such as post-processing that is suitable for resource constrained environment. In an IoMT application context, QRS-detection and R-peak localisation from ECG signal as a case study, the complexities of CNN models and post-processing were varied to identify a set of combinations suitable for a range of target resource-limited environments. To the best of our knowledge, finding a deploy-able configuration, by incrementally increasing the CNN model complexity, as required to match the target's resource capacity, and leveraging the strength of post-processing, is the first of its kind. The results show that a shallow 2-layer CNN with a suitable post-processing can achieve $>$90\% F1-score, and the scores continue to improving for 8-32 layer CNNs, which can be used to profile target constraint environment. The outcome shows that it is possible to design an optimal DL solution with known target performance characteristics and resource (computing capacity, and memory) constraints.
Products of generalized derivations on rings

In this paper, we show that if the product ( D 1 D 2 , d 1 d 2 ) of generalized derivations ( D 1 , d 1 ) and ( D 2 , d 2 ) on an algebra A is a generalized derivation, then d 1 D 2 and d 2 D 1 map A into rad( A ). Also, for generalized derivations ( D 1 , d 1 ) and ( D 2 , d 2 ) on a prime ring with characteristic diﬀerent from two, we give necessary and suﬃcient conditions under which ( D 21 + D 1 D 2 , d 21 + d 1 d 2 ) is a generalized derivation as well.
NICER/NuSTAR Characterization of 4U 1957+11: A Near Maximally Spinning Black Hole Potentially in the Mass Gap

4U 1957+11 is a black hole candidate system that has been in a soft X-ray spectral state since its discovery. We present analyses of recent joint NICER and NuSTAR spectra, which are extremely well described by a highly inclined disk accreting into a near maximally spinning black hole. Owing to the broad X-ray coverage of NuSTAR, the fitted spin and inclination are strongly constrained for our hypothesized disk models. The faintest spectra are observed out to 20 keV, even though their hard tail components are almost absent when described with a simple corona. The hard tail increases with luminosity, but shows clear two-track behavior with one track having appreciably stronger tails. The disk spectrum color-correction factor is anticorrelated with the strength of the hard tail (e.g., as measured by the Compton y parameter). Although the spin and inclination parameters are strongly constrained for our chosen model, the mass and distance are degenerate parameters. We use our spectral fits, along with a theoretical prior on color-correction, an observational prior on likely fractional Eddington luminosity, and an observational prior on distance obtained from Gaia studies, to present mass and distance contours for this system. The most likely parameters, given our presumed disk model, suggest a 4.6 M ⊙ black hole at 7.8 kpc observed at luminosities ranging from ≈1.7% to 9% of Eddington. This would place 4U 1957+11 as one of the few actively accreting sources within the mass gap of ≈2–5 M ⊙ where there are few known massive neutron stars or low-mass black holes. Higher mass and distance, however, remain viable.