Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinicopathological Study of Mucormycosis in COVID-19 Patients: Experience From a Tertiary Care Center in South India

Background: The coronavirus disease 2019 (COVID-19) pandemic has taken the world to different dimensions. With the surge of the second wave in India, the number of cases with mucormycosis has increased. Mucormycosis is a potentially life-threatening, opportunistic, invasive, fungal infection that can occur in immunocompromised states. The aim of the study is to analyze the clinicopathological parameters of patients with mucormycosis in the surge of the second wave of COVID-19. Materials and Methods: All cases of mucormycosis reported in the Department of Pathology in a tertiary care centre in South India from March 2021 to June 2021 were included in the study. The patient details were retrieved from the Medical Records section. The patient characteristics, location, associated comorbidities, management and treatment outcomes were analyzed and compared to similar studies reported worldwide. Results: Of 58 cases, 38 (65%) were males and 20 (35%) were females. The ages ranged from 34 to 77 years. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in 46 patients in reverse transcription polymerase chain reaction (RT-PCR) with high-resolution computed tomography (HRCT) Chest changes noted in 54 patients. Associated comorbidities were noted in 52 patients, with uncontrolled diabetes mellitus (46 patients; 88%) being the most common. Location was commonly in nasal and paranasal sinuses (43%), followed by orbital (2%), cerebral (10%) and pulmonary (8%) areas. Among the paranasal sinuses, the maxillary sinus was commonly involved. Mixed fungal infections (Aspergillus sp. and Candida sp.) were noted in eight (14%) cases. Oxygen therapy was given in 85% of cases; 30% of cases needed ventilator support; corticosteroid therapy was initiated in 49 patients, tocilizumab in six patients as treatment for mucormycosis. Amphotericin B was administered in 59% of patients based on clinical findings alone. After histopathological confirmation, 90% of them received amphotericin. Functional endoscopic sinus surgery (FESS) was done in 96% of cases, among them 45% underwent extensive surgical debridement and 15% underwent orbital decompression. Orbital exenteration (2%) was the other modality of management. Conclusion: Detailed analysis of clinicopathological features suggests the possibilities of immunosuppression (due to diabetes and use of corticosteroids in treatment of COVID-19) and COVID-19 (endothelial damage, cytokine storm) being the pathogenesis associated with the sudden surge of mucormycosis.
SNEDDS AS LIPID-BASED NANOCARRIER SYSTEMS: CONCEPTS AND FORMULATION INSIGHTS

Approximately 40 % of newly discovered chemical entities have low solubility and possess low bioavailability after oral administration. Lipid-based drug delivery systems (LBDDS) have recently become very popular because of their remarkable ability to deliver drugs with poor absorption using lipids as carriers. Self-emulsifying drug delivery (SEDDS) systems are one type of LBDDS employed for the incorporation of hydrophobic drugs. SEDDS are classified into self-micro emulsifying drug delivery systems (SMEDDS) and self-nano emulsifying drug delivery systems (SNEDDS) based on the droplet size of the dispersed phase. The present review focus on the mechanism of drug absorption from lipid-based nanocarriers systems, in vitro assessment of self-emulsification, insights of SNEDDS, factors affecting the formulation of SNEDDS, and its applications.
Mating and cannibalism dynamics of the fishing spider Dolomedes scriptus Hentz, 1845 (Araneae: Pisauridae)

Abstract. Sexual cannibalism is common in many species of arachnids. Studies investigating Dolomedes tenebrosus Hentz, 1844, have even discovered the occurrence of obligatory male self-sacrifice during copulation. In this system, females subsequently cannibalize males, and this cannibalism leads to higher fitness for both partners. Unfortunately, our understanding of the evolution of such an extreme mating system is challenged by the absence of information for close relatives. To that end, this study explores the courtship behavior, mating system and cannibalism dynamics of the spider Dolomedes scriptus Hentz, 1845. To determine whether female and male D. scriptus mate multiply, we recorded interactions of repeatedly exposed focal females and focal males to new mating partners for three days. We also quantified attacks and cannibalism events that occurred both before and after every copulation. We found male D. scriptus court females by waving their forelegs during their approach and tapping the females prior to mounting. In our remating trials, none of the female D. scriptus accepted additional males after their first mating over the three-day period. In contrast, male D. scriptus were polygynous, often mating with multiple females. Across the trials, sexual size dimorphism was a predictor of whether mating occurred, with similarly sized pairs being more likely to mate. Additionally, previously mated females were less likely to cannibalize males—an unusual pattern for spiders. Like other species of Dolomedes Latreille, 1804, our results suggest a strong role of female aggression in D. scriptus mating system dynamics.
GENETIC PREDICTION OF STRIPE RUST RESISTANCE THROUGH CROSSING ANZA A+ TO SIX EGYPTIAN WHEAT CULTIVARS

Anza A was crossed with 6 Egyptian wheat cultivars (Triticum aestivum, L.). These cultivars, F1, and F2 were tested under greenhouse conditions at seedling stage against pathotype (race) 230E18 of Puccinia striiformis. The cultivars and F1 possessed a susceptible (S) phenotype. The F2 populations were segregated into two gene pairs. The dominance tend direction of susceptibility. The resistance genes were recessive. On the other hand, at adult stage under field conditions against races mixture of the pathogen, Anza A possessed (R) phenotype, the F1 showed resistance of each all crosses. The F2 populations were segregated with 4 crosses (2 and 2) fitted the expected ratios 15 (R): 1(S) and 3 (R): 1(S). The other two crosses i.e., Anza A /Giza 168 and Anza A / Sakha94 appeared no segregated and dominance of resistance. The cultivars Giza 168 and Sakha94 may have the adult plant resistance gene Yr A under filed conditions. These findings confirmed that this gene is an effective under the Egyptian environmental conditions. Results obtained showed that partial stripe rust resistance in the tested wheat cultivars was controlled by one ore two gene pairs in most cases at seedling and adult stages. These results indicated that the selection for partial resistance materials in the early generations was possible while delaying it to late ones is more effective, due to the important role of dominance effect in the expression of this trait.
Angiogenesis Inhibitors and Immunomodulation in Renal Cell Cancers: The Past, Present, and Future

Simple Summary In their advanced stages, the mainstay of kidney cancer treatment is with medications such as targeted or immune therapies. Breakthroughs in scientific understanding of cancer drug development have led to substantial improvements in life expectancy. Although several combinations are available to choose from, it remains unclear which is best, and furthermore why cancers become resistant to treatment. This review article explores the scientific basis behind drug treatments in kidney cancers, with particular focus on blood vessel development and the immune system, and summarizes the available evidence supporting multi-drug treatments in this context. Abstract Angiogenesis inhibitors have been adopted into the standard armamentarium of therapies for advanced-stage renal cell carcinomas (RCC), but more recently, combination regimens with immune checkpoint inhibitors have demonstrated better outcomes. Despite this, the majority of affected patients still eventually experience progressive disease due to therapeutic resistance mechanisms, and there remains a need to develop novel therapeutic strategies. This article will review the synergistic mechanisms behind angiogenesis and immunomodulation in the tumor microenvironment and discuss the pre-clinical and clinical evidence for both clear-cell and non-clear-cell RCC, exploring opportunities for future growth in this exciting area of drug development.
Factors affecting female online purchase decision

This study enhances the existing literature on female online buying decisions by evaluating the factors shaping women’s clothing purchase decision-making. Hence, it investigates the influence of social media interactive marketing activities, i.e., electronic advertising (e-Ads), electronic word of mouth (e-WOM), interaction (Int.), and content credibility (CC), on female purchase decisions. The study adopted the logic of quantitative approach using an e questionnaire as a main data collection tool targeting online female consumers. Data were collected from 388 female social media users, and regression analysis was applied. The results of the study confirmed the association between a firm’s use of interactive marketing applications and activities and female purchase decisions. In addition, the results pointed out the electronic interactive activities of social media platforms such as e-Ads, CC, and e-WOM as powerful tools that support firm’s marketing strategies via their positive influence on female purchase decisions. The result is consistent with previous research (Park, Hyun, & Thavisay, 2021; Tran, 2017). The study provides several implications and recommendations for practice: focusing on content credibility, enriching the interactive content of brand name page, providing more details about offerings, and the continuous development of advertising, contents, and techniques. And for future research, as this study derived its findings from an evaluation carried out in the Jordanian clothing market, it is recommended to extend this evaluation to be conducted in other contexts and to consider other demographical and economic variables.
IN VITRO INSIGHTS REGARDING THE ROLE OF MELANIN IN MELANOMA CELLS’ RESPONSE TO BETULINIC ACID TREATMENT

Malignant melanoma (MM), the cancer arising from the normal-to-malignant switch of melanocytes, remains the most aggressive type of skin cancer with an annual increasing incidence worldwide. Based on the presence or absence of melanin, MM is divided in melanotic (pigmented) or amelanotic (non-pigmented) melanoma. Melanin is the natural pigment providing a protective role against harmful ultraviolet (UV) radiations and oxidative stress to epidermal melanocytes and surrounding keratinocytes. Recent studies reveal the ability of melanin to bind drugs via covalent and non-covalent bonds, leading to their accumulation within pigmented tissues which might influence the response of MM to chemotherapy. Betulinic acid (BA) is a pentacyclic triterpenoid possessing a multitude of therapeutic properties, including antimelanoma activity. The present study aimed to investigate the response of two MM cell lines to the antitumour effect of BA, considering their melanin content and to evaluate the cytotoxic potential of BA in healthy primary fibroblasts. The results reveal a dose-dependent decrease in the viability and confluence of all cell lines. However, SK-MEL-5 cells (IC50 =13.67 μM for 24 h, and 7.48 μM for 72 h) exerted a higher sensitivity to BA when compared to B16-F10 cells (IC50 = 52.12 μM for 24 h, and 25.54 for 72 h). BA induces a differential cytotoxicity in healthy, MM non-pigmented SK-MEL-5 and pigmented B16-F10 cells. Therefore, further studies are required to confirm the interaction between BA and melanin.
Association of Factor V Leiden G1691a in Women Suffering Repeated Abortions

Purpose: To assess the relationship of factor V leiden G1691A mutation as a risk factor for repeated pregnancy loss. The focus has been on factor V leiden G1691A mutation that may predispose women to microthrombosis during the stages of embryo implantation and placentation. Methods: A total of 70 women with recurrent pregnancy loss, mean age 31.1±4.2 years, were involved in the study. As a control group, 70 women [mean age 32.2±3.3 years with at least two live-born child and no history of abortion were included. We used real-time polymerase chain reaction (PCR) to determine the frequencies of factor V leiden G1691A genotype. Results: The frequency of heterozygotes for factor V leiden G1691A was significantly higher in women with repeated pregnancy loss compared to women without abortion (p = 0.0001). Conclusion: In summary we found an association of factor V leiden G1691A mutation with recurrent pregnancy loss . We recommend for factor V leiden G1691A screening in cases with repeated pregnancy loss so they can start anticoagulant therapy more earlier.
PERFORMANCE AND PHYSIOLOGICAL ASPECTS OF BROILER CHICKS FED DIETS CONTAINING VARIOUS LEVELS OF CANOLA MEAL

One hundred and fifty day–old Hubbard broiler chicks were used to investigate the effect of including low canola meal (Brassica campestris cv. Pactol) into broiler diets on their performance, internal organs relative weights and histology of liver and thyroid gland and economical efficiency throughout different growth stages. Birds were fed three periodical diets; starter, grower and finisher, based on cornsoybean meal. Canola meal (CM) was included into diets with levels of 0 (control), 10%, 12.5%, 15%, and 20%. The results indicated that, feed intake values were not affected by including canola meal into diets at different intervals (0-21, 22-32; 33-42 day), however feed consumption of chicks fed 20% canola was significantly lower for the entire experimental period. Body weight gain of chicks fed 20% canola meal were significantly lower than control ,while including canola meal up to 15% has no effect on body weight. Feed conversion ratio was not affected by 5% inclusion of canola meal, however, a negative but insignificant effect was observed with level of 10%. The relatives weight of each of dressing carcass, abdominal fat, liver, and spleen were not affected by including canola meal into diets. Thyroid gland percentage significantly increased due to incorporating canola meal into diets. Histological examination of liver and thyroid gland sections showed slight changes in the hepatocytes and thyroid follicles coincident with the level of canola meal inclusion level. In spit of included graded levels of canola meal into diets reduced total feed cost, the net revenue value of high inclusion level 20% (4.66LE) was lower than the control (4.9LE). As well, European efficiency factor and Performance index showed better values for control than canola meal feeding groups. It is concluded that 15% of CM in broiler diet is sufficient to obtain good performance and economical benefits without adverse effects on physiological status of birds.
A Study on Self-Efficacy and Academic Adjustment Among the Aviation-related College Students

Recently the departments of aviation-related in the college are increased as the aviation industry is rapidly expanded. To enhance their competitiveness and have differentiation, it is emphasized for each department to manage and teach their students well. Therefore this study aims to examine self-efficacy and academic adjustment of aviation-related college students and investigate the relationship between self-efficacy and academic adjustment. To achieve the objectives, it conducted a survey of aviation-related college students in C university from Apr. 27th. 2015 to May. 22th. 2015. A total of 225 questionnaires were analyzed using SPSS 18.0 statistical package program and frequency analysis, factor analysis, reliability analysis, multiple regression analysis, correlation analysis and one-way ANOVA were conducted. The result released that general self-efficacy was recognized higher at the department of aviation operation than aviation maintenance and aviation service and social self-efficacy was recognized higher at the department of aviation service than aviation maintenance and aviation operation. Also general self-efficacy had an influence on the motivation, application and performance and social self-efficacy affected motivation, performance and academic environment. The implication of these findings would help to manage aviation-related college students, develop their departments and provide the directions for future research.
Effect of Direct-Acting Antivirals on Lipid and Glucose Metabolism in Chronic HCV Patients

Introduction: Hepatitis C virus (HCV) infection is a global public health burden, total global HCV prevalence is estimated at 2.5% (177 million of HCV infected adults), Considerable differences are present among different populations. For example, the HCV prevalence in Egypt is 10-15%. Aim of the study: The aim of this study is to determine the effect of treatment with DAAs on serum lipids (total cholesterol, low and high density cholesterol, triglycerides, ox LDL) and Insulin Resistance (HOMA_IR) in chronic HCV patients. Patients and Methods: Study design: Our Prospective study aimed to determine the effect of treatment with Direct Acting Antivirals (DAAs) on lipid and glucose metabolism in chronic hepatitis C patients. Results: Eighty six chronic hepatitis c patients were included in this study, the patients were consecutively from admitted and/or attendant of out patient’s clinic of Tropical Medicine Department, Minia University Hospitals. The main results of the study were summarized in the following tables and figures. Conclusion: The DAAs therapy is highly effective in treatment of chronic hepatitis c patients especially (SOF/DAC) regimen, reaching about 100% SVR.
PHYTOCHEMICAL ANALYSIS AND MINERAL ELEMENTS COMPOSITION OF DATURA STRAMONIUM FOLLOWING BIOFERTILIZERS APPLICATION

Azospirillum brasilense or/ and Azotobacter vinelandii are employed in agriculture as biofertilizers. The main target of the present study is to assess the effect of nitrogen fixing microorganisms to improve and boost medicinal plants therapeutic effectiveness and better growth using Datura stramonium as an indicator plant. The inoculation of Datura stramonium with Azospirillum or/and Azotobacter partially or completely counteracted the improvements on some minerals content and secondary metabolic mechanisms. Generally, the application of Azospirillum or/ and Azotobacter as biofertilizers enhance the metallic contents of Datura stramonium and improve therapeutic effectiveness.
Autologous intrauterine platelet rich plasma instillation in repeated implantation failure in assisted reproductive techniques

Background: RIF (repeated implantation failure) represents a serious difficulty in reproductive medicine, and although numerous therapeutic approaches can be reported, there is no agreement on which is the most beneficial. Endometrium thickness was identified as a key determinant in the implantation of embryos. The purpose of this randomized controlled trial was to explore the advantages of platelet rich plasma (PRP) for thinning endometrial cases owing to its ability to promote endometrial growth and pregnancy outcome. Aim of the work: PRP's involvement in RIF patients undergoing fresh & frozen embryo transfer cycles will be investigated, as well as the rates of implantation, chemical pregnancy, clinical pregnancy, and miscarriage. Patients and methods: In this study, 104-women who had at least three failed embryo transfer cycle due to poor endometrial lining were candidates for frozen-thawed and fresh embryo transfer. Two groups of patients were formed: The study group (48 patients) got PRP intrauterine infusion. Control group who didn’t practiced. When endometrium thickness is about 7 mm, embryo transfer was achieved. Endometrial thickness and clinical results were compared in the two groups. Results: In the 13th day of the cycle, The Endometrial Thickness-(mm) were 7.1±0.01 for control and 8.1±0.054 for test group. The rate of implantation, chemical pregnancy, clinical pregnancy and misscarriage% were 34.8, 33.3, 22.9 and 10.4% for control group; and 58.5, 52.1, 45.8 and 6.3% for test group. The Endometrial Thickness (mm) expanded significantly to 7.23±0.11 and 8.3±0.60 mm in First PRP infusion and Repeated PRP infusion group, respectively. The PRP group had significantly greater implantation rates and clinical outcomes. Conclusion: In women who have a history of thin endometrium, PRP may help to improve endometrial development and possibly pregnancy results.
Social Media Driven Big Data Analysis for Disaster Situation Awareness: A Tutorial

Situational awareness tries to grasp the important events and circumstances in the physical world through sensing, communication, and reasoning. Tracking the evolution of changing situations is an essential part of this awareness and is crucial for providing appropriate resources and help during disasters. Social media, particularly Twitter, is playing an increasing role in this process in recent years. However, extracting intelligence from the available data involves several challenges, including (a) filtering out large amounts of irrelevant data, (b) fusion of heterogeneous data generated by the social media and other sources, and (c) working with partially geo-tagged social media data in order to deduce the needs of the affected people. Spatio-temporal analysis of the data plays a key role in understanding the situation, but is available only sparsely because only a small fraction of people post relevant text and of those very few enable location tracking. In this paper, we provide a comprehensive survey on data analytics to assess situational awareness from social media big data.
Does Dietary Yeast Extract Improve the Performance and Health of Quail Breeders Reared under High Stocking Density?

This study was designed to study the effects of stocking density without or with yeast extracts supplementation on productive and reproductive performance, digestive enzymes, blood biochemical parameters, and antioxidant and immune measurements of quail breeders. A total number of 336 Japanese quail birds at 8 weeks old were used. Quails were randomly distributed into 6 groups and 4 replicates maintained / each group in a complete randomized design. The 1 group contained 36 birds (24 females and 12 males) was stocked at a rate of 9 birds /replicate (control, ND; 36 quails/m) and fed the basal diet without any supplementation; the 2, 3, 4, 5 and 6 groups contained 60 quails (40 females and 20 males) and stoked at a rate of 15 chicks/replicate (HD; 60 quails/m) and fed on a basal diet supplemented with 0, 1, 2, 3 and 4 mg YE /kg diet, respectively. Egg number, egg weight and egg mass were significantly decreased (P<.0001) due to increasing stocking density from ND (9/cage) to HD (15/cage) and fed without dietary YE supplementation. The activity of SOD (p<0.0001), TAC (p<0.0001) and GPX (p=0.0047) was improved with HD plus YE when compared to HD. Digestive enzymes (amylase, lipase, and protease) activity was decreased with HD when compared to ND. It could be concluded that addition of yeast extract can positively mitigate the stress applied to quail raised under high stoking density by enhancing productive and reproductive performance, lipid profile, antioxidants and immunity as well as egg quality criteria.