Miracle-dz/UniFAR-FTUs huggingface dataset:
Pseudo-Elastic Response of Gas Bearing Clastic Formations: An Italian Case Study

The research presented in this paper focuses on the analysis of land movements induced by underground gas storage operations in a depleted reservoir in Northern Italy with the aim of increasing the understanding of the deformation response of deep formations via a real case study. The a priori knowledge of the pseudo-elastic parameters showed a substantial discrepancy between static values from triaxial lab tests and dynamic values obtained via the interpretation of sonic data at wellbore scale. The discrepancy is not surprising for the formations under investigation: A thousand meters of a silty to shaly sequence intercalated with arenaceous banks above a reservoir formation, which is basically made up of sandstone intercalated with shale intervals and conglomerates. Information collected for over more than ten years of seasonal production/injection cycles (i.e., time and space evolution of the reservoir fluid pressure and of the induced land surface movements) was then combined in a 3D numerical geomechanical model to constrain and update the a priori knowledge on the pseudo elastic model parameters via a back analysis approach. The obtained calibrated model will then be used for reliable prediction of system safety analyses, for example in terms of induced ground movements.
The Moderating Role of Age in the Effect of Video Playback Speed on Urgency Perception in the Context of Climate Change

Urgency perception plays a vital role in addressing the issue of climate change. However, little is known about how to promote the perceived urgency of climate change and its potential influence on proenvironmental intention and behavior. This research focuses on a potentially significant but less studied factor in video communication: video playback speed. The current research explores the effectiveness of video playback speed as a subtle behavioral nudge to influence urgency perception and proenvironmental response in the context of climate change. We conducted two survey-embedded experiments in which participants watched a climate change video playing at either normal or fast speed and then completed measurements. Data were collected first in an undergraduate sample (n = 75) and then in a general population sample (n = 300) and analyzed using Mann–Whitney U tests, chi-squared tests, and moderation analysis in SPSS. The results reveal that a fast playback speed of climate change video decreases the perceived urgency of climate change for younger consumers, not for older consumers. However, video playback speed does not influence proenvironmental intention and behavior. These findings enhance understanding of when video playback speed affects urgency perception and proenvironmental tendency, and provide valuable insights for climate change communication.
The nature of inconsistencies in two measures of risk preferences in a sample of young African South Africans

Abstract In this paper, we attempt to unpack the nature of revealed inconsistencies in two measures of risk preferences for a sample of young African South Africans. The first measure is a self-reported propensity to take risk in general, and the second is a risk preference elicited through a hypothetical financial gamble. We find that the majority of individuals are inconsistent in their responses that provide these two measures of risk preferences with the majority of contradictions coming from individuals reporting themselves as risk seeking, when their revealed risk preferences from the hypothetical gamble show them to be risk averse. Our results suggest that such inconsistencies are more prevalent amongst males, and amongst females with greater mathematical ability.
First Demonstration of 1-bit Erase in Vertical NAND Flash Memory

We propose for the first time a method for erasing one selected cell in Vertical NAND (VNAND) flash memory. By controlling the voltage applied to the terminals (switch devices and cells) of the VNAND string array, 1-bit erase (GIDL generation) of one selected cell and erase inhibition (GIDL suppression) of unselected cells are successfully verified. Compared to the existing method, the 1-bit erase method reduces the current fluctuation by 17 times at an IBL of 50 nA and reduces the Vth dispersion of >2 V to ~0.2 V or less.
Dengue, Chikungunya, and Zika: Spatial and Temporal Distribution in Rio de Janeiro State, 2015–2019

Simultaneous spatial circulation of urban arboviral diseases, such as dengue, chikungunya, and Zika, is a major challenge. In this ecological study of urban arboviruses performed from 2015 to 2019, we analyzed the spatial and temporal dynamics of these arboviruses in all 92 municipalities and nine health regions of Rio de Janeiro state. Annual cumulative incidences are presented for all three arboviruses throughout the study period. Spatial analyses of the three studied arboviruses showed distinct behaviors among municipalities and health regions. Co-circulation of the three arboviruses in the state and a heterogeneous spatiotemporal pattern was observed for each disease and region, with dengue having a higher annual incidence during the five years of the study, as well as two consecutive epidemic years in the state. The increase in transmission in different regions of the state in one year culminated in an epidemic in the state in the following year. A high annual cumulative incidence of chikungunya occurred in municipalities from 2017 to 2019 and of Zika only in 2016. Some municipalities with higher population densities showed higher incidences for some arboviruses and appeared to contribute to the dissemination to cities of lower demographic density and maintenance of these urban arboviruses. Thus, regions recording increased incidences of the three diseases in their territories for long periods should be considered municipal poles, as they initiated and sustained high transmission within their region.
Perbaikan Kualitas Kimia Vertisol Melalui Pemberian Bahan Organik Mucuna, Crotolaria, dan Dosis Pupuk Hayati

The purpose of this study was to evaluate the effect of the treatment of organic material sources Mucuna and Crotolaria and the dose of vesicle arbuscular mycorrhizae (VAM) on the chemical quality of vertisol, nutrient uptake and maize yield in dry land. The research was carried out in the experimental field of the Kupang State Agricultural Polytechnic, in the village of Oesao, East Kupang District, Kupang Regency, East Nusa Tenggara. The study took place from May to September 2021. The study design used a factorial randomized block design. The first factortreatment was source of organic matter (B) of ground cover plant biomass, namely: B0 = no ground cover plant biomass; BM = Mucuna and its biomass are immersed; BC = Crotolaria and its biomass immersed. The second treatment was dose of VAM biofertilizer (D), namely: M0 = 0 g plant-1 (without VAM); M1 = 10 g plant-1; M2 = 20 g plant-1. The results showed that the application of organic material sources and the dose of VAM, respectively, could significantly improve the chemical properties of vertisol. The results showed that the use of organic matter and dose of VAM independently was proven to be the most effective in improving the chemical quality of vertisol. Application of organic matter Mucuna and Crotolaria at a dose of VAM 20 g plant-1 significantly increased N uptake in maize by 53.26‒54.45%, maize P uptake by 27.83% and 28.85%, and the yield of dry shelled corn by 146.92% and 146.92% compared to other treatments. Keywords: organic matter, vesicle arbuscular mycorrhizae, soil chemical
Divergence between Willingness and Behavior of Farmers to Purchase Socialized Agricultural Services: From a Heterogeneity Perspective of Land Scale

The low-level dilemma of farmers’ Socialized Agricultural Services (SAS) purchases is a realistic problem facing the construction of socialized service systems in China’s major grain-producing areas. Existing research lacks the necessary attention on the decision-making mechanism of farmers’ purchases of SAS, resulting in a large gap between theoretical research and real-world problems. Based on the data of 638 households in China’s main grain-producing areas, this paper empirically analyzes the influence mechanism of heterogeneous land scale on deviation between farmers’ willingness and behavior to purchase SAS, and discusses the heterogeneity of the influence mechanism under different production links. The findings indicate that the degree of divergence between farmers’ willingness to purchase SAS and their behavior is large. (1) There is a significant threshold effect of land scale on the degree of divergence between farmers’ willingness and behavior to purchase SAS, and the threshold value is ten mu. The increase in land scale will significantly enlarge the divergence between small-scale farmers’ purchase willingness and behavior. However, it will significantly reduce the divergence between large-scale farmers’ purchase willingness and behavior. (2) From the demand side, household income and health will significantly reduce the divergence among farmers of different business sizes. Family burden and land fragmentation are essential factors affecting the degree of divergence of small-scale farmers, while education and the value of their own machinery significantly affect the degree of divergence of large-scale farmers. From the supply side, whether there are local suppliers and their matching degree with farmers significantly reduces the divergence among farmers of different business scales. However, small-scale farmers are more sensitive to the price and quality of agricultural services, while large-scale farmers have higher requirements for the degree of regulation of supplying agents. (3) There is heterogeneity in the influence mechanisms of divergence between farmers’ willingness to purchase SAS and their behavior under different product segments. In addition, our findings highlight how to realize the transformation from declarative preference to explicit preference in promoting farmers’ purchases of SAS.
Forecasting a short‐term wind speed using a deep belief network combined with a local predictor

This article proposes a novel wind speed forecast algorithm framework, which combines a deep belief network (DBN) and an improved Local Predictor (LP). The DBN adopted is a multiple hidden layers deep neural network consisting of restricted Boltzmann machines (RBMs) with superior performances on classification and prediction applications of a large‐scale dataset, such as wind speed data. However, it is known that the time series of wind speed under certain weather conditions have different patterns. Therefore, it is difficult to represent these patterns using a single model. Thus, a data‐filtering technique based on phase space reconstruction, LP, is used to embed one‐dimension high‐variance time series to a high dimensional space, and to select the training samples having the same pattern as the forecast sample. Therefore, a DBN with a Local Predictor (DBNLP) can be applied to forecast the wind speed using large‐scale training samples, which provides more reliable forecast results. In the experimental studies, the proposed algorithm is evaluated on the wind speed data collected from AIMS weather station in Australia. The forecast performance is compared with the commonly used predictors, including Auto‐Regressive Moving Average (ARMA), Support Vector Machines (SVMs), and Artificial Neural Networks (ANNs), respectively. The results demonstrate that the proposed algorithm exhibits a better performance than the other algorithms under various forecast steps. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Back pain syndrome in nurses in Podkarpackie hospitals

Zespoły bólowe kręgosłupa są ogromnym problemem zdrowotnym. Dotyczą najczęściej osób pomiędzy 40 i 60 rokiem życia, ale zdarza się, że występują jeszcze przed 30 rokiem życia. U pielęgniarek są powszechnym zjawiskiem. Etiologia tych dolegliwości jest wieloczynnikowa. Zasadniczą przyczyną są obciążenia fizyczne kręgosłupa: dźwiganie, wymuszona postawa ciała oraz nadwaga. Istotną rolę odgrywają też predyspozycje neurofizjologiczne człowieka i uwarunkowania społeczne. W pracy podjęto próbę ustalenia, czy osoby badane znają przyczynę swoich dolegliwości, wiedzą, jaka powinna być profilaktyka tego schorzenia, znają zasady ergonomii oraz działania prozdrowotne w tym zakresie.W pracy określono częstość występowania zespołów bólowych kręgosłupa u pielęgniarek w dwóch szpitalach na Podkarpaciu. Posłużono się autorską ankietą i badaniami antropometrycznymi. Ból występował u 89% badanych, a zasadniczą przyczyną dolegliwości były obciążenia fizyczne, nadwaga i niska aktywność fizyczna. Osoby badane znały zasady ergonomii, ale nie wykorzystywały ich w pracy, a staż nie miał tu statystycznie istotnego znaczenia. Odnotowano brak szkoleń i odpowiedniego sprzętu. Jedynie u 13% badanych czynniki stresowe miały wpływ na dolegliwości bólowe kręgosłupa. Ból pleców występuje u 90% badanych w szpitalach na Podkarpaciu i ma cechy choroby zawodowej. Respondenci znają zasady ergonomii i wyrażają chęć pogłębienia swojej wiedzy na ten temat. Wiedzę tę należy uzupełnić o podstawowe wiadomości z zakresu aktywnej fizjoterapii i neurofizjologii ze względu na rolę czynników psychologicznych w leczeniu przewlekłego bólu.
Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches

Microtubule affinity regulating kinase 4 (MARK4) regulates the mechanism of microtubules by its ability to phosphorylate the microtubule-associated proteins (MAP’s). MARK4 is known for its major role in tau phosphorylation via phosphorylating Ser262 residue in the KXGS motif, which results in the detachment of tau from microtubule. In lieu of this vital role in tau pathology, a hallmark of Alzheimer’s disease (AD), MARK4 is a druggable target to treat AD and other neurodegenerative disorders (NDs). There is growing evidence that NDs and diabetes are connected with many pieces of literature demonstrating a high risk of developing AD in diabetic patients. Metformin (Mtf) has been a drug in use against type 2 diabetes mellitus (T2DM) for a long time; however, recent studies have established its therapeutic effect in neurodegenerative diseases (NDs), namely AD, Parkinson’s disease (PD) and amnestic mild cognitive impairment. In this study, we have explored the MARK4 inhibitory potential of Mtf, employing in silico and in vitro approaches. Molecular docking demonstrated that Mtf binds to MARK4 with a significant affinity of −6.9 kcal/mol forming interactions with binding pocket’s critical residues. Additionally, molecular dynamics (MD) simulation provided an atomistic insight into the binding of Mtf with MARK4. ATPase assay of MARK4 in the presence of Mtf shows that it inhibits MARK4 with an IC50 = 7.05 µM. The results of the fluorescence binding assay demonstrated significant binding of MARK4 with a binding constant of 0.6 × 106 M−1. The present study provides an additional axis towards the utilization of Mtf as MARK4 inhibitor targeting diabetes with NDs.
Promising Therapeutic Strategies Targeting Mitochondria in Kidney Diseases: From Small Molecules to Whole Mitochondria

Kidney function highly depends on mitochondria, organelles that regulate different metabolic pathways. Mitochondria-altered function and structure are present during acute kidney injury (AKI) and chronic kidney disease (CKD). Targeting mitochondria using several strategies has been shown to improve kidney function. Here, we review some experimental mitochondria targeting strategies with clinical potential in kidney diseases encompassing cationic/lipophilic small molecules, peptides, nanocarriers, and even the entire organelle.
Effects of Throughflow and Gravity Modulation on Thermal Convection in a Couple Stress Fluid Saturated Porous Layer

In this paper, we have investigated the effects of throughflow and gravity modulation on a couple stress fluid saturated porous layer using non-autonomous Ginzburg-Landau model. A small variation of disturbances has been considered to examine the nonlinear thermal instability in a couple stress fluid saturated porous media. At third order, the finite amplitude of convection has been calculated which determines heat transfer. The effect of throughflow i.e., inflow and outflow have dual nature of heat transfer. The couple-stress parameter has stabilizing nature on thermal instability. The couple-stress parameter has stabilizing nature on thermal instability. Further it is found that upward directed flow enhances and downward directed flow diminishes heat transfer.
CD147 Promotes Tumorigenesis via Exosome-Mediated Signaling in Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is an aggressive childhood soft-tissue tumor, with propensity for local invasion and distant metastasis. Exosomes are secreted vesicles that mediate paracrine signaling by delivering functional proteins and miRNA to recipient cells. The transmembrane protein CD147, also known as Basigin or EMMPRIN, is enriched in various tumor cells, as well as in tumor-derived exosomes, and has been correlated with poor prognosis in several types of cancer, but has not been previously investigated in RMS. We investigated the effects of CD147 on RMS cell biology and paracrine signaling, specifically its contribution to invasion and metastatic phenotype. CD147 downregulation diminishes RMS cell invasion and inhibits anchorage-independent growth in vitro. While treatment of normal fibroblasts with RMS-derived exosomes results in a significant increase in proliferation, migration, and invasion, these effects are reversed when using exosomes from CD147-downregulated RMS cells. In human RMS tissue, CD147 was expressed exclusively in metastatic tumors. Altogether, our results demonstrate that CD147 contributes to RMS tumor cell aggressiveness, and is involved in modulating the microenvironment through RMS-secreted exosomes. Targeted inhibition of CD147 reduces its expression levels within the isolated exosomes and reduces the capacity of these exosomes to enhance cellular invasive properties.
Sensitive Detection of Pharmaceutical Drugs and Metabolites in Serum Using Data-Independent Acquisition Mass Spectrometry and Open-Access Data Acquisition Tools

Data-independent acquisition (DIA) based strategies have been explored in recent years for improving quantitative analysis of metabolites. However, the data analysis is challenging for DIA methods as the resulting spectra are highly multiplexed. Thus, the DIA mode requires advanced software analysis to facilitate the data deconvolution process. We proposed a pipeline for quantitative profiling of pharmaceutical drugs and serum metabolites in DIA mode after comparing the results obtained from full-scan, Data-dependent acquisition (DDA) and DIA modes. using open-access software. Pharmaceutical drugs (10) were pooled in healthy human serum and analysed by LC-ESI-QTOF-MS. MS1 full-scan and Data-dependent (MS2) results were used for identification using MS-DIAL software while deconvolution of MS1/MS2 spectra in DIA mode was achieved by using Skyline software. The results of acquisition methods for quantitative analysis validated the remarkable analytical performance of the constructed workflow, proving it to be a sensitive and reproducible pipeline for biological complex fluids.
PENGARUH KUALITAS LAYANAN PERBANKAN, PENINGKATAN FASILITAS E-BANKING DAN KEPUASAN NASABAH TERHADAP LOYALITAS PADA PT. BNI CABANG HANGNADIM BATAM

Penelitian ini bertujuan bertujuan untuk mengetahui pengaruh kualitas layanan perbankan, peningkatan fasilitas E-banking dan kepuasan nasabah terhadap loyalitas pada PT. BNI Cabang Hangnadim Batam. Rancangan penelitian ini adalah dengan pendekatan deskriptif dengan bentuk hubungan kausal dan jenis penelitian yang digunakan adalah kuantitatif, dengan jumlah sampel sebanyak.100 responden. Metode dalam penelitian ini yaitu metode regresi linear berganda dengan menggunakan aplikasi IBM SPSS Statistics 25 sebagai tools untuk mengolah data. Hasil penelitian ini menunjukan bahwa terdapat pengaruh kualitas layanan perbankan dan kepuasan nasabah terhadap loyalitas secara signifikan. Artinya, hipotesis yang diajukan dalam penelitian ini dapat diterima dengan nilai t hitung > t tabel yaitu 1,984, sedangkan peningkatan fasilitas E-banking tidak berpengaruh terhadap loyalitas. Secara simultan ketiga variabel tersebut yakni kualitas layanan perbankan, peningkatan fasilitas E-banking dan kepuasan nasabah berpengaruh signifikan terhadap loyalitas. Maka kesimpulan dari penelitian ini adalah variabel kualitas layanan perbankan dan kepuasan nasabah berpengaruh signifikan terhadap loyalitas, sedangkan variabel peningkatan fasilitas E-banking tidak terbukti berpengaruh terhadap loyalitas. Berdasarkan kesimpulan tersebut peneliti memberikan saran kepada Bank BNI agar lebih meningkatkan fasilitas E-banking untuk memudahkan nasabah dalam bertransaksi.
Nimotuzumab Increases the Recovery Rate of Severe and Critical COVID-19 Patients: Evaluation in the Real-World Scenario

EGFR signaling is an important regulator of SARS-CoV induced lung damage, inflammation and fibrosis. Nimotuzumab is a humanized anti-EGFR antibody registered for several cancer indications. An expanded access study was conducted to evaluate the safety and recovery rate of severe and critical patients with confirmed SARS-CoV-2 infection, treated with nimotuzumab in combination with the standard of care in the real-world scenario. The antibody was administered as an intravenous infusions every 72 h, up to 5 doses. In order to assess the impact of nimotuzumab, the recovery rate was compared with a paired retrospective cohort. Control patients received standard treatment according the national protocol but not nimotuzumab. Overall, 1,151 severe or critical patients received nimotuzumab in 21 hospitals of Cuba. Median age was 65 and 773 patients had at least one comorbidity. Nimotuzumab was very well-tolerated and mild or moderate adverse events were detected in 19 patients. 1,009 controls matching with the nimotuzumab patients, were selected using a “propensity score” method. The 14-day recovery rate of the nimotuzumab cohort was 72 vs. 42% in the control group. Controls had a higher mortality risk (RR 2.08, 95% CI: 1.79, 2.38) than the nimotuzumab treated patients. The attributable fraction was 0.52 (95% CI: 0.44%; 0.58), and indicates the proportion of deaths that were prevented with nimotuzumab. Our preliminary results suggest that nimotuzumab is a safe antibody that can reduce the mortality of severe and critical COVID-19 patients.
Acoustic Account of Prosodic Competence through Shadowing

Adopting an acoustic framework, this experimental study elucidates the effect of shadowing technique on prosodic competence of learners of English whose L1 (Arabic) and English have quite dissimilar phonological systems. It is appertained to prosodic aspects such as pauses, stress, and sound length that cause challenges to non-English native speakers. Two individuals of heterogeneous linguistic background participated in a pre-test and a post-test before and after five weeks of shadowing sessions. The data was analyzed acoustically using Praat Software. Findings showed that the participant with the elementary level outperformed the other participant whose level was intermediate, partially because the former was highly motivated to improve her English. The study concluded that shadowing per se is no way a panacea for improving supra-segmental features unless it is coupled with a motivation to do so, regardless of the level of proficiency. Keywords: Pauses, Pronunciation, Prosody, Shadowing, Supra-segmental Features