Miracle-dz/UniFAR-FTUs huggingface dataset:
Thermoacoustic Modes of Quasi-One-Dimensional Combustors in the Region of Marginal Stability

It may be generally believed that the thermoacoustic eigenfrequencies of a combustor with fully acoustically reflecting boundary conditions depend on both flame dynamics and geometry of the system. In this work, we show that there are situations where this understanding does not strictly apply. The purpose of this study is twofold. In the first part, we show that the resonance frequencies of two premixed combustors with fully acoustically reflecting boundary conditions in the region of marginal stability depend only on the parameters of the flame dynamics but do not depend on the combustor's geometry. This is shown by means of a parametric study, where the time delay and the interaction index of the flame response are varied and the resulting complex eigenfrequency locus is shown. Assuming longitudinal acoustics and a low Mach number, a quasi-1D Helmholtz solver is utilized. The time delay and interaction index of the flame response are parametrically varied to calculate the complex eigenfrequency locus. It is found that all the eigenfrequency trajectories cross the real axis at a resonance frequency that depends only on the time delay. Such marginally stable frequencies are independent of the resonant cavity modes of the two combustors, i.e., the passive thermoacoustic modes. In the second part, we exploit the aforementioned observation to evaluate the critical flame gain required for the systems to become unstable at four eigenfrequencies located in the marginally stable region. A computationally efficient method is proposed. The key ingredient is to consider both direct and adjoint eigenvectors associated with the four eigenfrequencies. Hence, the sensitivity of the eigenfrequencies to changes in the gain at the region of marginal stability is evaluated with cheap and accurate calculations. This work contributes to the understanding of thermoacoustic stability of combustors. In the same manner, the understanding of the nature of distinct resonance frequencies in unstable combustors may be enhanced by employing the analysis of the eigenfrequency locus here reported.
Effect of gas flow on a helium/oxygen endoscopic plasma jet

This experimental study characterized the effect of carrier gas flow on an endoscopic plasma jet. This system generates and transports helium plasma in a tube over several meters, along with a separate channel transporting oxygen to enhance plasma reactivity on site. The resulting plasma plume exiting the tube allows treatment of tissue surfaces in an endoscopic setting with a view to perform therapeutic operations in the gastrointestinal tract. In a closed cavity simulating the tract, the carrier gas flow was studied by a combined approach investigating plasma plume chemistry, fluid dynamics, and plasma effects on the surface of a hydrogel tissue model reporting oxidation. These three aspects are shown to be closely inter-related. Plasma plume length, intensity, and shape strongly depend on helium content, velocity, turbulence, and environment. Optical emission spectroscopy was used to show that the helium gas flow rate increases the amount of helium and reactive oxygen species (ROS) in the plume. Schlieren imaging was used to visualize the transition of the fluid from buoyant to laminar and finally turbulent depending on flow rate, with a backflow in a closed cavity. Finally, the frontal and radial treatment of the cavity was assessed by measuring ROS delivery to a KI-starch agarose gel model. Helium flow rate had a noticeable effect on the treatment distribution profile and treatment intensity, with different maxima for frontal and radial treatments. This combined approach, in an accurate simulation of the target configuration (i.e. a closed, cylindrical cavity), is necessary to optimize treatment, as its outcome depends on a balance between ROS production, transport, and distribution.
Lightning Transient Analysis Comparison and Wind Turbine Models Using PSCAD/EMTDC Circuit Simulator

This paper aims to compute the lightning electromagnetic transient overvoltage and current on the wind turbine using the PSCAD/EMTDC simulation program. The double-peaked lightning current, tower, grounding system models, and dangerous situation of the grounding system are investigated by the PSCAD simple circuit branch segment codes and defining components. A comparison analysis has been performed to see the influence of lightning current wave shapes and grounding characteristics. The simulation results show that 43 kA and 31 kA lightning currents produce 200 kV overvoltage on the turbine grounding in case of 1000 Ω·m soil resistivity. However, current amplitudes on the equipotential grounding system become 28 kA and 20 kA. The influencing factors of the surge protection device are determined using good accuracy computer simulation.
Systematic review: Analysis of the use of D-limonene to Reduce the Environmental Impact of Discarded Expanded Polystyrene (EPS).

The article presents a systematic review on the use of D-limonene with the aim of analyzing its efficiency to reduce the environmental impact of expanded polystyrene (EPS). Initially, an analysis of the life cycle of the EPS was carried out in a general way to identify the stage where the greatest impact on the environment is evident. Subsequently, primary sources were examined that raise the issue of reducing EPS using this green solvent, in view of the fact that it generates sustainability through recycling, optimization and application of various methods that could allow the circular economy of this waste in order to be applied in the industrial field and contribute to the socio-environmental aspect. Finally, the importance of this solvent was demonstrated according to the analysis and evaluation of each EPS recycling examining country.
Kinematics of the galaxy's stellar populations from a proper motion survey.

A sample of reliable absolute proper motions, with no kinematic or metallicity bias, including 2370 stars, has been analysed in a 7 square degree field at b = 80°. Distances have been derived using B and V magnitudes. The distributions of the U and V components of the Galactic space motions with respect to the Sun have been studied in different bins of distance up to 2.75 kpc above the plane. Using a stochastic ML algorithm, stellar populations have been deconvolved, allowing the determination of some parameters of their velocity distribution and spatial distribution. The old disk is found to have a scale length of 6 ± 2 kpc, with mean velocity (U, V) = (0 ± 6, −19 ± 3) km/s and velocity dispersions (σ U , σ V ) = (44 ± 6, 24 ± 4) km/s
Experimental maneuverability and agility quantification for rotary unmanned aerial vehicle

Multicopters are the most popular rotary type of unmanned aerial vehicles. They are a type of helicopter with three or more, usually fixed-pitch, propellers that lift and control the platform by individually changing their rotational velocities. The main advantages of a multicopter are its compactness, robustness, and low cost to build and repair. However, currently no published research determines objectively, quantitatively, and experimentally, the maneuverability and agility of multicopters. Numerous maneuverability and agility metrics, together with detailed test procedures and minimum requirements, exist for manned aircraft. Nevertheless, some of these are not directly applicable to small-size unmanned aircraft. A new test procedure, derived from manned aircraft industry practices and research, based on a simple open-loop step input maneuver, was developed. It experimentally determines nine maneuverability and agility metrics using only onboard flight controller logs. The test procedure is validated using two different multicopters.
Stricter protocols combined with a clinical serum biomarker can increase replicability and causality for dietary intervention studies. Plus empirical data on BPA regrettable substitutions

Effective regulation of harmful environmental chemicals found in wide variety of consumer products and consumables has been thwarted by the lack of agreement between government scientists and university/academic laboratories regarding the quantification of significant human harms. This is particularly relevant regarding plastic-derived chemicals (PDCs), such as Bisphenol A, now that the federal CLARITY-BPA program has failed to achieve any credible, human-significant scientific consensus. Because of this disagreement, direct, clinical human experimental data is vital to resolving this situation. In an effort to develop direct human-relevant data, some academic investigators have employed dietary intervention studies in an attempt to shed light on the controversy. Unfortunately, dietary intervention efforts thus far have not demonstrated causality or replicability. Investigators of this study propose a novel human dietary intervention protocol that can be both replicable and causal. This first-of-a-kind dietary intervention study explores a potential causal relationship between human serum levels of BPA and High-Sensitivity C-Reactive Protein (hsCRP), a proven clinical indicator of inflammation. Investigators used the equivalent of a USDA-defined typical diet followed by a PDC-reduced diet to compare blood levels of hsCRP. This proof-of-concept investigation is the first to use an easily accessible, medically-accepted clinical laboratory test to directly measure human health effects of PDC reduction. Unexpected phenomena discovered during the investigation offer study protocol modifications to enhance widespread replicability, and economically practical expansion to a substantial proportion of the approximately 84,000 mostly unregulated chemicals found in the human environment. In addition, our LC/MS-MS results offer the first direct quantitative human clinical evidence (of which we are aware) confirming the existence of regrettable substitutions in which product manufacturers have reduced BPA usage while substituting Bisphenol analogues that appear to equal or exceed BPA human toxicity. Bolstered by the unexpected results in this proof-of-concept investigation, novel lessons and techniques described herein may further specific and improved methods and best practices that can enable future dietary interventions to produce replicable, causal human results.
Cost-utility and cost-effectiveness analysis of disease-modifying drugs of relapsing–remitting multiple sclerosis: a systematic review

Background Multiple sclerosis (MS) is a chronic, autoimmune, and inflammatory disease. The economic burden of MS is substantial, and the high cost of Disease-modifying drugs (DMDs) prices are the main drivers of healthcare expenditures. We conducted a systematic review of studies evaluating the cost-utility and cost-effectiveness of DMDs for relapsing–remitting multiple sclerosis (RRMS). Materials and method Searches were conducted in PubMed, Web of Science, Scopus, and Embase. The search covered articles published between May 2001 and May 2023. Studies that were written in English and Persian and examined the cost-utility and cost-effectiveness of DMDs in patients with MS were included in our review. Data extraction was guided by the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist, and the quality of economic evaluations was assessed using the Quality of Health Economics Studies Instrument (QHES). All costs were converted to 2020 U.S. dollars using Purchasing Power Parity (PPP). Results The search yielded 1589 studies, and 49 studies were eligible for inclusion. The studies were mainly based on a European setting. Most studies employed Markov model to assess the cost–effectiveness. The lowest and highest numerical value of outcome measures were -1,623,918 and 2,297,141.53, respectively. Furthermore, the lowest and highest numerical value of the cost of DMDs of RRMS were $180.67, and $1474840.19, respectively. Conclusions Based on the results of all studies, it can be concluded that for the treatment of patients with MS, care-oriented strategies should be preferred to drug strategies. Also, among the drug strategies with different prescribing methods, oral disease-modifying drugs of RRMS should be preferred to injectable drugs and intravenous infusions.
Writing ferroelectric domain bits on the PbZr0.48Ti0.52O3 thin film

PbZr0.48Ti0. 52O3 thin films were fabricated on (111) Pt/TiO2/SiO2/Si substrate by eclipse pulsed laser deposition with the very low deposition rate of 0.02 A/pulse. High crystalline PbZr0.48Ti0. 52O3 thin films showed a good ferroelectric property with the high remanent polarization of 48 μC/cm2 as well as an enhanced fatigue behavior. The small roughness of PZT thin films makes a negligible influence on electron force microscope images, which gave the enhanced resolution for the observation of a minimum ferroelectric bit size. We demonstrated the minimum ferroelectric bits below 9 nm, which were clearly observed.
IL-13 alleviates idiopathic pulmonary hypertension by inhibiting the proliferation of pulmonary artery smooth muscle cells and regulating macrophage infiltration.

BACKGROUND Idiopathic pulmonary arterial hypertension (IPAH) is characterized by medial hypertrophy due to pulmonary artery smooth muscle cell (PASMC) hyperplasia. In the present study, we conducted bioinformatic analyses and cellular experiments to assess the involvement of the interleukin-13 (IL-13) in IPAH. METHODS The differentially expressed genes (DEGs) in IPAH and DEGs in IPAH caused by IL-13 treatment were screened using the GEO database. PPI networks were used to analyze the hub genes. Hypoxia-induced PASMCs were treated with IL-13 for in vitro assays. CCK8 and EdU staining were used to observe proliferation of PASMCs, and RT-qPCR was applied to detect the expression of hub genes. The conserved binding sites of microRNAs (miRNAs) in the 3'UTR of hub genes were investigated, and the regulatory relationships of the relevant miRNAs on their targets were verified by RT-qPCR and dual-luciferase assays. The GO and KEGG analyses were performed to study the downstream pathways. The effect of hub genes on immune cell infiltration in IPAH was investigated. RESULTS IL-13 altered gene expression in IPAH. IL-13 inhibited the proliferation and the expression of hub genes in PASMCs. The 3'UTR sites between HNRNPA2B1, HNRNPH1, SRSF1, HNRNPU and HNRNPA3 in the hub genes and candidate regulatory miRNAs were well conserved in humans. IL-13-mediated hub genes regulated multiple pathways and influenced immune cell infiltration. Hypoxia-induced PASMCs promoted the M2 polarization of macrophages, whereas IL-13-treated PASMCs skewed the macrophages toward M1 polarization. CONCLUSIONS IL-13-mediated alterations in hub genes inhibit PASMC proliferation and promote M1 macrophage infiltration in IPAH.
Examining the Relationship between Academic Expectations and Suicidal Ideation among College Students in India Using the Interpersonal Theory of Suicide

Abstract Objective As the second most populous country in the world, India accounts for over 20% of the global suicide deaths. Notably, young adults make up 38% of those who die by suicide in India. Yet, the literature on factors associated with suicide within this age group in India is limited. The Interpersonal Theory of Suicide (IPTS) posits thwarted belongingness and perceived burdensomeness as constructs that heighten the risk for suicide. Testing mechanisms that may mediate the relationship between common stressors for young adults in India, such as academic expectations, and suicidal ideation are important to better understand factors contributing to suicide risk within this country. Method Indian college students (N = 432, M age = 19.41, 73.1% male) completed questionnaires on academic expectations, thwarted belongingness, perceived burdensomeness, collectivism, and suicidal ideation. Results Current suicidal ideation was endorsed at a rate of 38%. Academic expectancy from the self, perceived burdensomeness, and thwarted belongingness was significantly associated with suicidal ideation. The only significantly mediated pathway was academic expectancy from others to suicidal ideation through perceived burdensomeness. Collectivism was not a significant moderator in the model. Discussion The sample endorsed high rates of suicidal ideation, highlighting the need for culturally appropriate interventions. Thwarted belongingness, perceived burdensomeness, and academic expectations from oneself may be relevant treatment targets for reducing suicidal ideation among college students in India. HIGHLIGHTS Over one-third of Indian university students endorsed suicidal ideation. Suicidal ideation related to one’s own more than others’ academic expectations. Results offer support for the Interpersonal Theory of Suicide within this context.
Telehealth v. face-to-face provision of care to patients with depression: a systematic review and meta-analysis

Abstract Ensuring continuity of care for patients with major depressive disorders poses multiple challenges. We conducted a systematic review and meta-analysis of randomised controlled trials comparing real-time telehealth to face-to-face therapy for individuals with depression. We searched Medline, Embase, and Cochrane Central (to November 2020), conducted a citation analysis (January 2021), and searched clinical trial registries (March 2021). We included randomised controlled trials comparing similar or identical care, delivered via real-time telehealth (phone, video) to face-to-face. Outcomes included: depression severity, quality of life, therapeutic alliance, and care satisfaction. Where data were sufficient, mean differences were calculated. Nine trials (1268 patients) were included. There were no differences between telehealth and face-to-face care for depression severity at post-treatment (SMD −0.04, 95% CI −0.21 to 0.13, p = 0.67) or at other time points, except at 9 months post-treatment (SMD −0.39, 95% CI −0.75 to −0.02, p = 0.04). One trial reported no differences in quality-of-life scores at 3- or 12-months post-treatment. One trial found no differences in therapeutic alliance at weeks 4 and 14 of treatment. There were no differences in treatment satisfaction between telehealth and face-to-face immediately post-treatment (SMD −0.14, 95% CI −0.56 to 0.28, p = 0.51) or at 3 or 12-months. Evidence suggests that for patients with depression or depression symptoms, the provision of care via telehealth may be a viable alternative to the provision of care face-to-face. However, additional trials are needed with longer follow-up, conducted in a wider range of settings, and with younger patients.
Multi-step recognition of potential 5' splice sites by the Saccharomyces cerevisiae U1 snRNP

In eukaryotes, splice sites define the introns of pre-mRNAs and must be recognized and excised with nucleotide precision by the spliceosome to make the correct mRNA product. In one of the earliest steps of spliceosome assembly, the U1 small nuclear ribonucleoprotein (snRNP) recognizes the 5' splice site (5' SS) through a combination of base pairing, protein-RNA contacts, and interactions with other splicing factors. Previous studies investigating the mechanisms of 5' SS recognition have largely been done in vivo or in cellular extracts where the U1/5' SS interaction is difficult to deconvolute from the effects of trans-acting factors or RNA structure. In this work we used colocalization single-molecule spectroscopy (CoSMoS) to elucidate the pathway of 5' SS selection by purified yeast U1 snRNP. We determined that U1 reversibly selects 5' SS in a sequence-dependent, two-step mechanism. A kinetic selection scheme enforces pairing at particular positions rather than overall duplex stability to achieve long-lived U1 binding. Our results provide a kinetic basis for how U1 may rapidly surveil nascent transcripts for 5' SS and preferentially accumulate at these sequences rather than on close cognates.
Biomechanical effect of Coflex and X-STOP spacers on the lumbar spine: a finite element analysis.

OBJECTIVE To explore the biomechanical differences between Coflex and X-STOP devices by finite element analysis. METHODS Based on the normal lumbar CT images from a healthy adult volunteer, four finite element models including the healthy lumbar segment model, the mild degenerated lumbar segment model, a Coflex fixed lumbar segment model and X-STOP fixed lumbar segment model were constructed. A simulation analysis under the conditions of flexion, extension, lateral bending, and rotation was performed to compare range of motion (ROM), intradiscal pressure, the facet joint force, the maximum Von Mises stress and the peak facet contact forces, between Coflex and X-STOP devices. RESULTS Compared to the mild degenerated lumbar segment model at surgical level L4-L5, Coflex and X-STOP could reduce ROM in extension by 98.34% and 95.86%, respectively, decrease peak stress of intervertebral discs in extension by 59.4% and 66.17%, respectively, and release peak force of facet joint in extension by 97.09% and 95.42%, respectively. Both devices had no significant impact on adjacent levels. The maximum Von Mises stress in Coflex device was 637.56 Mpa in flexion, 528.86 Mpa in extension, while the maximum Von Mises stress in X-STOP device was 476.65 Mpa at extension position. The peak facet contact forces of Coflex and X-STOP devices appeared in extension and were 19.76 Mpa and 49.28 Mpa, respectively. CONCLUSIONS Coflex and X-STOP devices can effectively decrease the ROM and intradiscal pressure in extension, without affecting the adjacent levels.
Effectiveness of chronic disease self-management education (CDSME) programs to reduce loneliness

Objectives With about half of older adults reporting feelings of loneliness, interventions are needed to improve connectedness among our aging population. The health benefits of Chronic Disease Self-Management Education (CDSME) programs are well documented, but workshops’ ability to reduce loneliness remains unknown. Methods Using the Campaign to End Loneliness Measurement Tool, we examined 295 CDSME participants’ loneliness changes before and after the 6-week face-to-face workshops. Statistical analyzes used generalized estimating equations (GEE). Results On average, participants were age 74.3(±8.9) years and self-reported 3.3(±2.2) chronic conditions. The majority of participants were female (83%) and attended workshops in English (77%). Significant reductions in loneliness scores were observed from baseline to post-workshop (p < 0.001). Discussion Findings expand our understanding about the benefits of small-group CDSME workshops to reduce loneliness among participants. CDSME workshops may reduce loneliness because of their highly interactive and process-driven format and ability to create bonds between participants with chronic conditions and shared experiences.