Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of the blood oxygen level dependent hemodynamic response function in human subcortical regions with high spatiotemporal resolution

Subcortical brain regions are absolutely essential for normal human function. These phylogenetically early brain regions play critical roles in human behaviors such as the orientation of attention, arousal, and the modulation of sensory signals to cerebral cortex. Despite the critical health importance of subcortical brain regions, there has been a dearth of research on their neurovascular responses. Blood oxygen level dependent (BOLD) functional MRI (fMRI) experiments can help fill this gap in our understanding. The BOLD hemodynamic response function (HRF) evoked by brief (<4 s) neural activation is crucial for the interpretation of fMRI results because linear analysis between neural activity and the BOLD response relies on the HRF. Moreover, the HRF is a consequence of underlying local blood flow and oxygen metabolism, so characterization of the HRF enables understanding of neurovascular and neurometabolic coupling. We measured the subcortical HRF at 9.4T and 3T with high spatiotemporal resolution using protocols that enabled reliable delineation of HRFs in individual subjects. These results were compared with the HRF in visual cortex. The HRF was faster in subcortical regions than cortical regions at both field strengths. There was no significant undershoot in subcortical areas while there was a significant post-stimulus undershoot that was tightly coupled with its peak amplitude in cortex. The different BOLD temporal dynamics indicate different vascular dynamics and neurometabolic responses between cortex and subcortical nuclei.
Multi-model seasonal prediction of global surface temperature based on partial regression correction method

The increased climate change is having a huge impact on the world, with the climatic change sensitive and vulnerable regions at significant risk particularly. Effective understanding and integration of climate information are essential. It helps to reduce the risks associated with adverse weather conditions and to better adapt to the impacts of climate variability and change. Using the hindcast data from Japan Meteorological Agency/Meteorological Research Institute (JMA/MRI) coupled prediction system version 2 (JMA/MRI-CPS2), National Centers for Environmental Prediction (NCEP) Climate Forecast System model version 2 (CFSv2), and Canadian Centre for Climate Modeling and Analysis (CCCma) Coupled Climate Model, versions 3 (CanCM3) seasonal prediction model systems, the performance of seasonal prediction for global surface temperature in boreal summer and winter is comprehensively evaluated and compared for 1982–2011 from the perspective of deterministic and probabilistic forecast skills in this study, and a partial regression correction (PRC) method is introduced to correct seasonal predictions. The results show high prediction skills in the tropics, particularly in the equatorial Pacific, while poor skills on land. In general, JMA/MRI-CPS2 has slightly better prediction performance than CFSv2 and CanCM3 in the tropics. CFSv2 is generally superior to JMA/MRI-CPS2 and CanCM3 in the extratropical northern hemisphere and East Asia, especially for the abnormal low winter temperature prediction in East Asia. CanCM3 shows good deterministic forecast skills in extra-tropics but performs slightly worse in probabilistic forecasting. Based on the respective strengths of each seasonal prediction model, an ensemble forecast correction with observational constraint is implemented by partial regression, and the improvement of skills in ensemble predicting has been analyzed. Compared to the simple multi-model ensemble (MME), the correction improved the global-average temporal correlation coefficient and multi-year mean anomaly correlation coefficient by about 0.1 and 0.13, respectively. The validation tests indicate that the corrected ensemble forecast has higher ranked probability skill scores than that of the MME, which is improved by more than 0.06 in the tropics. Meanwhile, when the training period is sufficiently long, it may have the potential for future seasonal temperature predictions from the perspective of stable zonal partial regression coefficients.
Association between lifestyle and COVID-19 vaccination: A national cross-sectional study

Objective To assess lifestyles, COVID-19 vaccination coverage rates, and the relationships between lifestyles and COVID-19 vaccination among Chinese population. Methods We collected data on sociodemographics, perception of the COVID-19 pandemic, lifestyles, and self-reported COVID-19 vaccination via an online survey in China. The chi-square goodness-of-fit test was used to monitor sample saturation throughout the formal online survey. The binary logistic regression analyses were conducted to examine the association between COVID-19 vaccination rate and lifestyle score. We assigned values to 12 lifestyles ranging from positive to negative, with positive lifestyles receiving a higher score and negative lifestyles receiving a lower score, ranging from 1 to 5. For each participant, the total lifestyle scored from 12 to 56. Restricted cubic spline (RCS) was used to visualize the trends and correlations between lifestyle score and COVID-19 vaccination coverage. Propensity score matching (PSM) was used to explore the association between specific lifestyles and COVID-19 vaccination. Results A total of 29,925 participants (51.4% females) responded. The lifestyle score of the sample was 44.60 ± 6.13 (scoring range: 12–56). COVID-19 vaccination rate was found to be 89.4% (89.1–89.8%). Female participants reported a higher vaccination rate than male participants (91.5 vs. 87.1%). Compared to Q1, COVID-19 vaccination coverage rates increased with lifestyle total scores [ORQ2 = 1.901 (1.718–2.103), P < 0.001; ORQ3 = 2.373 (2.099–2.684), P < 0.001; and ORQ4 = 3.765 (3.209–4.417), P < 0.001]. After applying PSM, it was determined that all the 12 specific healthy lifestyles analyzed, including maintaining a healthy body weight, a healthy diet, regular physical exercises, adequate sleep, regular physical examination, and others, were found to be positive factors for COVID-19 vaccination. Conclusion The majority of mainland Chinese lived a healthy lifestyle throughout the COVID-19 pandemic, and the rate of COVID-19 vaccination was high. Specific healthy lifestyles contributed to COVID-19 vaccination coverage rates significantly. According to the study's findings, global efforts to achieve herd immunity should be prioritized by continually promoting healthy lifestyles and improving public perception of COVID-19 vaccines.
Descriptive peer drinking norms and binge drinking: Enhancement motives as a mediator and alcohol resistance self-efficacy as a moderator

The association between descriptive norms regarding peer drinking and college students’ binge drinking has been established; however, the mediating and moderating mechanisms underlying this relationship among first-and second-year college students remain minimally explored. Drawing on social norms theory, motivational model of alcohol use, and the theory of normative social behavior, the current study investigated whether enhancement drinking motives mediated the relationship between descriptive norms regarding peer drinking and college students’ binge drinking, and whether this relationship was moderated by alcohol resistance self-efficacy. Five hundred and nineteen first-and second-year college students (Mage = 19.19 years, SD = 0.98) who were from four universities and had at least one time of heavy episodic drinking during the last year completed self-report questionnaires. After controlling for sex, age, and university variable, stronger descriptive norms regarding peer drinking were positively associated with a greater frequency of binge drinking. Enhancement drinking motives partially mediated the effects of descriptive peer drinking norms on binge drinking. Furthermore, alcohol resistance self-efficacy moderated the direct effects of descriptive peer drinking norms on binge drinking. Compared with college students who reported high alcohol resistance self-efficacy, the direct effects of descriptive peer drinking norms on binge drinking were stronger among students with low alcohol resistance self-efficacy. These findings point to the potential value of alcohol intervention approaches including efforts to help first-and second-year college students change enhancement drinking motives and increase their ability of resisting drinks in the context of pervasive peer drinking.
LigA formulated in AS04 or Montanide ISA720VG induced superior immune response compared to alum, which correlated to protective efficacy in a hamster model of leptospirosis

Leptospirosis is a zoonotic disease of global importance. The current vaccine provides serovar-specific and short-term immunity and does not prevent bacterial shedding in infected animals. Subunit vaccines based on surface proteins have shown to induce protection in an animal model. However, these proteins were tested with non-clinical adjuvants and induced low to moderate protective efficacy. We formulated a variable region of Leptospira immunoglobulin-like protein A (LAV) in clinical adjuvants, AS04 and Montanide ISA720VG, and then evaluated the immune response in mice and protective efficacy in a hamster model. Our results show that animals immunized with LAV-AS04 and LAV-Montanide ISA720VG (LAV-M) induced significantly higher levels of LAV-specific antibodies than LAV-Alum. While LAV-Alum induced Th2 response with the induction of IgG1 and IL-4, AS04 and LAV-M induced a mixed Th1/Th2 response with significant levels of both IgG1/IL-4 and IgG2c/IFN-γ. Both LAV-AS04 and LAV-M induced the generation of a significantly higher number of cytotoxic T cells (CTLs). The immune response in LAV-AS04- and LAV-M-immunized animals was maintained for a long period (>180 days) with the generation of a significant level of B- and T-cell memory. The strong immune response by both vaccines correlated to enhanced recruitment and activation of innate immune cells particularly DCs at draining lymph nodes and the formation of germinal centers (GCs). Furthermore, the immune response generated in mice correlated to protective efficacy in the hamster model of leptospirosis. These results indicate that LAV-AS04 and LAV-M are promising vaccines and can be further evaluated in clinical trials.
Transcriptional profiling of long non-coding RNAs regulating fruit cracking in Punica granatum L. under bagging

Fruit cracking tremendously damages the appearance of fruit, easily leads to pathogen invasion, greatly reduces the marketability and causes immense economic losses. The pivotal role of long non-coding RNAs (lncRNAs) in diverse biological processes has been confirmed, while the roles of lncRNAs underlying fruit cracking remain poorly understood. In this study, the incidence of fruit cracking was 7.26% under the bagging treatment, the control group was 38.11%, indicating that bagging considerably diminished the fruit cracking rate. LncRNA libraries for fruit cracking (FC), fruit non-cracking (FNC) and fruit non-cracking under bagging (FB) in pomegranate (Punica granatum L.) were performed and analysed via high-throughput transcriptome sequencing. A total of 3194 lncRNAs were obtained with a total length of 4898846 nt and an average length of 1533.77 nt in pomegranate. We identified 42 differentially expressed lncRNAs (DELs) and 137 differentially expressed mRNAs (DEGs) in FC vs FNC and 35 DELs and 160 DEGs in FB vs FC that formed co-expression networks respectively, suggesting that there are involved in phytohormone signaling pathway, lignin catabolic process, lipid transport/binding, cutin biosynthetic process and cell wall organization. We also found that 18 cis-acting DELs regulated 18 target genes, and 10 trans-acting DELs regulated 24 target genes in FC vs FNC, 23 DELs regulate 23 target genes for the cis-acting lncRNAs and 12 DELs regulated 36 target genes in FB vs FC, which provides an understanding for the regulation of the fruit cracking. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis results demonstrated that DELs participated in calcium ion binding, glycerophospholipid metabolism, flavonoid biosynthetic process, cell wall biogenesis, xyloglucan metabolic process, hormone signal transduction and starch and sucrose metabolism. Our findings provide new insights into the roles of lncRNAs in regulating the fruit cracking and lay the foundation for further improvement of pomegranate quality.
Monitoring the Galactic Centre with the Australia Telescope Compact Array

The supermassive black hole, Sagittarius A* (Sgr A*), at the centre of the Milky Way undergoes regular flaring activity which is thought to arise from the innermost region of the accretion flow. We performed the monitoring observations of the Galactic Centre to study the flux-density variations at 3mm using the Australia Telescope Compact Array (ATCA) between 2010 and 2014. We obtain the light curves of Sgr A* by subtracting the contributions from the extended emission around it, and the elevation and time dependent gains of the telescope. We perform structure function analysis and the Bayesian blocks representation to detect flare events. The observations detect six instances of significant variability in the flux density of Sgr A* in three observations, with variations between 0.5 to 1.0 Jy, which last for 1.5 $-$ 3 hours. We use the adiabatically expanding plasmon model to explain the short time-scale variations in the flux density. We derive the physical quantities of the modelled flare emission, such as the source expansion speed $v_{\mathrm{exp}}$, source sizes, spectral indices, and the turnover frequency. These parameters imply that the expanding source components are either confined to the immediate vicinity of Sgr A* by contributing to the corona or the disc, or have a bulk motion greater than $v_{\mathrm{exp}}$. No exceptional flux density variation on short flare time-scales was observed during the approach and the flyby of the dusty S-cluster object (DSO/G2). This is consistent with its compactness and the absence of a large bow shock.
Seroprevalence and risk factors of Toxoplasma gondii and Neospora caninum infection in black goats in Yunnan Province, Southwestern China

Toxoplasma gondii and Neospora caninum are two obligate intracellular protozoan parasites that can cause reproductive failure and production losses. To date, there is no data of T. gondii and N. caninum seroprevalence in black goats in Yunnan Province, southwestern China. In the present study, a total of 734 serum samples were collected from black goats in four different counties of Yunnan Province. 734 and 590 serum samples were examined for antibodies against T. gondii and N. caninum by using MAT and indirect ELISA, respectively. A total of 123 and 76 samples were T. gondii-positive and N. caninum-positive, respectively. The overall seroprevalence of T. gondii in black goats was 16.76% (123/734, 95% CI: 14.06–19.46) with the titer ranged from 1:25 to 1:3200. The seroprevalence of N. caninum was 12.88% (76/590, 95% CI: 10.18–15.58). There was significant difference in seroprevalence of N. caninum in different regions (P < 0.01, χ2 = 30.63) and age groups (P < 0.05, χ2 = 11.85). Significant differences in seroprevalence of T. gondii were observed in different regions (P < 0.05, χ2 = 9.21) and different gender groups (P < 0.01, χ2 = 12.29). Results of seroprevalence of T. gondii and N. caninum indicated that T. gondii and N. caninum were prevalent parasites in black goats in Yunnan Province. This is the first report of seroprevalence of T. gondii and N. caninum in black goats in Yunnan Province. The results of this study indicated that some measures should be taken to control these two parasites and to reduce economic losses to the livestock industry in Yunnan Province.
Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei City

Background Hepatitis B surface antigen (HBsAg) loss is considered a functional cure for chronic hepatitis B (CHB), however, several factors influence HBsAg loss. Methods 29 CHB patients who had achieved HBsAg loss, were selected and 58 CHB patients with persistent HBsAg were matched, according to gender and age (+/- 3 years). Logistic regression and restricted cubic spline (RCS) modelling were performed. Results Multivariate-adjusted logistic regression, based on stepwise selection, showed that baseline HBsAg levels negatively correlated with HBsAg loss (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.98-0.99). Interferon treatment positively related with HBsAg loss (OR = 7.99, 95%CI = 1.62-44.88). After adjusting for age, HBsAg level, ALT level, HBeAg status and interferon treatment, MMP-1 (OR = 0.66, 95%CI = 0.44-0.97), CXCL9 (OR = 0.96, 95%CI = 0.93-0.99) and TNF-R1 (OR = 0.97, 95%CI = 0.94-0.99) baseline levels all negatively correlated with HBsAg loss. Our multivariate-adjusted RCS model showed that baseline CXCL10 was associated with HBsAg loss although the relationship was “U-shaped”. Conclusions Cytokines such as MMP-1, CXCL9, CXCL10 and TNF-R1 are important factors which influence HBsAg loss. It may be possible to develop a nomogram which intercalates these factors; however, further research should consider immune processes involved in HBsAg loss.
Seroprevalence and risk factors of tropical theileriosis in smallholder asymptomatic large ruminants in Egypt

Knowledge of the prevalence and epidemiological determinants of tropical theileriosis in large ruminants, particularly in the asymptomatic carrier, is crucial for designing and implementing effective host-specific control measures. This study aimed to estimate the seroprevalence of tropical theileriosis in asymptomatic cattle and water buffaloes and identify the potential risk factors of theileriosis in large ruminants raised under smallholder-production system in Egypt. A cross-sectional study was conducted in five districts of the Sharkia governorate from March 2019 to February 2020. In total, 350 serum samples were collected from cattle and water buffaloes under smallholder-production system and tested for Theileria annulata antibodies using the indirect antibody fluorescence test (IFAT). Data on species, host characteristics, presence of ticks, season, and districts were collected at sampling using a questionnaire. A multivariable mixed-effects logistic regression model was built to determine the potential risk factors associated with T. annulate seropositivity of the animals. The overall apparent seroprevalence of T. annulata in 350 tested animals was 70%. In the univariable analyses, cattle compared to buffaloes, younger animals compared to older ones, animals with ticks on their bodies, and warmer seasons were all associated with a higher likelihood of seropositive results in the study population while sex of the animals was not associated with seropositivity. The final multivariable model showed that animals with ticks on their bodies had 3.5× higher odds of seropositivity than those with no ticks (P < 0.001), and warmer seasons were associated with the higher odds of infection compared to winter (P = 0.003). The high seroprevalence of tropical theileriosis in the study region indicates that the disease is endemic among smallholders of large ruminants. The identified risk factors of T. annulata-seropositivity in asymptomatic carrier animals provides evidence-based guidance for adopting effective intervention measures.
Fire resistance of composite shear walls filled with demolished concrete lumps and self-compacting concrete

The recycling and reuse of waste concrete is conducive to promoting the sustainable development of resources and practicing the concept of green development. Demolished concrete lumps (DCLs) and self-compacting concrete (SCC) made from waste concrete take full advantage of their recyclability. In order to fully utilize the advantages of demolished concrete lumps and self-compacting concrete in construction, applying demolished concrete lumps and self-compacting concrete to composite shear wall structures is an effective way to reduce costs and improve industrial production. In this paper, a new composite shear wall filled with demolished concrete lumps and self-compacting concrete is proposed, and its fire performance is investigated. The shear wall combines edge constraints of concrete-filled steel tubes, demolished concrete lumps and self-compacting concrete. In order to facilitate the mass pouring of demolished concrete lumps, a cavity is formed between the steel tubes at the ends and the precast walls on both sides. A double-sided fire tests was conducted on three composite shear wall specimens filled with demolished concrete lumps and self-compacting concrete at a constant axial compression ratio, where the fire-retardant coating and the wall width-to-depth ratio were considered as the main test parameters. The specimens were able to steadily withstand the predetermined axial loads during the fire resistance time of 180 min and showed good fire resistance. The concrete temperature variation trends of the three specimens in the wall section were basically the same. The fire-retardant coating on the concealed column had a significant effect on the section temperature of the steel tube, while increasing the wall width-to-depth ratio had little effect. When the axial compression ratio was 0.19, the specimens were in the expansion stage within 180 min and no compression occurred. The results show that the expansion deformation of the shear wall sprayed with fire-retardant coating on the outer surface of the concealed column is smaller than that of the shear wall without fire-retardant coating, and the axial deformation of the composite shear wall infilled with demolished concrete lumps and self-compacting concrete is not affected by increasing the wall width-to-depth ratio.
An in vitro bladder model with physiological dynamics: Vesicoureteral reflux alters stent encrustation pattern

In vitro models are indispensable to study the physio-mechanical characteristics of the urinary tract and to evaluate ureteral stent performances. Yet previous models mimicking the urinary bladder have been limited to static or complicated systems. In this study, we designed a simple in vitro bladder model to simulate the dynamics of filling and voiding. The physio-mechanical condition of the model was verified using a pressure-flow test with different bladder outlet obstruction levels, and a reflux test was performed to qualitatively demonstrate the stent associated vesicoureteral reflux (VUR). Finally, the setup was applied with and without the bladder model to perform encrustation tests with artificial urine on commercially available double-J stents, and the volumes of luminal encrustations were quantified using micro-Computed Tomography and image segmentation. Our results suggest that, VUR is an important factor contributing to the dynamics in the upper urinary tract with indwelling stents, especially in patients with higher bladder outlet obstruction levels. The influence of VUR should be properly addressed in future in vitro studies and clinical analyses.