Miracle-dz/UniFAR-FTUs huggingface dataset:
Thermal ablation assisted laparoscopic partial nephrectomy for clinical T1b renal tumors

Abstract Objective To report our preliminary results of thermal ablation, including microwave and radiofrequency ablation assisted laparoscopic partial nephrectomy for cT1b renal tumors. Material and methods A total of 56 patients with cT1b renal tumors who underwent microwave ablation or radiofrequency ablation assisted laparoscopic partial nephrectomy between January 2014 and May 2018 were enrolled. Thirty of them underwent microwave ablation assisted laparoscopic partial nephrectomy (MWA-LPN group), and the other 26 received radiofrequency ablation assisted laparoscopic partial nephrectomy (RFA-LPN group). Baseline, perioperative and follow-up data were compared between the two groups. Results There were no statistical differences with respect to patients’ gender, age, tumor size, RENAL score, BMI and estimated glomerular filtration rate between the MWA-LPN and RFA-LPN group, nor were any differences observed in warm ischemia time, post-operative complications and hospital stay. Patients in the MWA-LPN group had shorter median operative time (p = .012), less estimated blood loss (p = .023). Median follow-up was 36 months (range 12–64). Three-year cancer-specific and progression-free survival was 100% and 96.4%. The overall kidney recurrence rate was 3.6% in the present study. Conclusions Thermal ablation assisted laparoscopic partial nephrectomy is a safe, effective nephron-sparing treatment which provides acceptable results for selective cT1b renal tumors.
Testing the Generalizability of the Event Process Model of Family Violence With an Incarcerated Sample

The event process model of family violence (FVEPM) presents a descriptive theory of a family violence (FV) event from the perpetrator’s perspective. Developed in a community setting, the FVEPM is comprised of four interrelated sections and describes three pathways to FV perpetration (Pathway 1: Conflict escalation, Pathway 2: Automated violence, and Pathway 3: Compliance). This study further developed the FVEPM by testing the generalizability of the model and its pathways with an incarcerated sample of eight men with extensive histories of violent and other offending. Event narratives were gathered during individual semi-structured interviews, and were systematically analyzed using grounded theory methods. Overall, findings suggest that the FVEPM and its pathways can accommodate an incarcerated sample. However, several inconsistencies were found: Event narratives were better represented by splitting Pathway 1 into two sub-types, and no event narratives were assigned to Pathway 3. Implications for FV theories and treatment are discussed.
New record of Boa constrictor occidentalis Philippi, 1873 (Serpentes: Boidae) in San Juan province, Argentina

We document the first record of Boa constrictor in Valle Fertil department, San Juan province, Argentina. The specimen was collected and deposited in the herpetological collection of the Department of Biology, Universidad Nacional San Juan. This record extends the known distribution for this species in San Juan province by 105 km.
Evaluation of adverse drug reaction reports in adult patients on antiretroviral therepy in Ahmadu Bello University Teaching hospital Zaria-Nigeria

Antiretroviral therapy (ART) has reduced morbidity and mortality in HIV patients. In Nigeria, there are over 400,000 patients on ART in over 200 secondary and tertiary hospitals. However, data on adverse drug reactions (ADRs) due to ARTs are limited. The aim of this study was to evaluate ADRs reports in adult patients on ART in Ahmadu Bello University Teaching Hospital Zaria (ABUTH). The study was a retrospective cross-sectional study on randomly selected adult patients on ART with ADR reports in Nasara Clinic of ABUTH, between January, 2012 and December, 2013. Medical records and ADR reports of the patients were reviewed and fitted into a structured questionnaire. Data were analyzed using SPSS Version 20.0. The study reviewed the records of 302 patients on ART as per the sample size out of a total of 1405 patients in the register within the study period. Of the 302 patients, 109 (36.1%) were reported to have at least one form of ADR, majority of whom were females 65 (59.6%). The most common ADRs were cough (34%), skin rash (44%), headache (20%) and diarrhea (10%), with few cases of anemia (5.5%), lipodostrophy (3.6%) and neuropathy (1.8%). 55% and 98% had concomitant disease and medications respectively. The actions taken to manage the ADR were; specific treatment of the ADR (69.7%), change of ARV regimen (22%) and few cases of hospitalization (6.4%). In conclusion, the study revealed the occurrence of ADRs in adult patients on ART in ABUTH. These reactions occurred within few months of medication, and were found to be related to age, social factor, ART regimen, gender, as well as other concomitant diseases and medications. Close monitoring is required to prevent severe ADR and improve adherence. Keywords : Antiretroviral therapy, adverse drug reaction, cough, retrospective
Application of Fuzzy Logic Sugeno Methods for Diagnosis Typhoid Fever Disease and Dengue Hemorrhagic Fever

Typhoid fever and dengue hemorrhagic fever are common diseases in Indonesia. Typhoid fever is caused by bacteria while dengue hemorrhagic fever is caused by the dengue virus. Both of these diseases are often misdiagnosed because they have the same symptoms as other diseases so that they can cause the high rate of death. Therefore, it takes an expert system as a tool to diagnose typhoid fever and dengue hemorrhagic fever to be handled quickly and precisely. The Expert system built by using the Sugeno Fuzzy Logic method. It expected to be a solution to facilitate the public to diagnose typhoid fever and dengue hemorrhagic fever based on the symptoms and get treatment solutions. This study has produced expert system to diagnose typhoid fever and dengue hemorrhagic Fever. It had been tested 86 cases of data with an accuracy value is 80.2%.
Network analysis, sequence and structure dynamics of key proteins of coronavirus and human host, and molecular docking of selected phytochemicals of nine medicinal plants

Abstract The novel coronavirus of 2019 (nCoV-19) has become a pandemic, affecting over 205 nations with over 7,410,000 confirmed cases which has resulted to over 418,000 deaths worldwide. This study aimed to identify potential therapeutic compounds and phytochemicals of medicinal plants that have potential to modulate the expression network of genes that are involve in SARS-CoV-2 pathology in human host and to understand the dynamics key proteins involved in the virus-host interactions. The method used include gene network analysis, molecular docking, and sequence and structure dynamics simulations. The results identified DNA-dependent protein kinase (DNA-PK) and Protein kinase CK2 as key players in SARS-CoV-2 lifecycle. Among the predicted drugs compounds, clemizole, monorden, spironolactone and tanespimycin showed high binding energies; among the studied repurposing compounds, remdesivir, simeprevir and valinomycin showed high binding energies; among the predicted acidic compounds, acetylursolic acid and hardwickiic acid gave high binding energies; while among the studied anthraquinones and glycosides compounds, ellagitannin and friedelanone showed high binding energies against 3-Chymotrypsin-like protease (3CLpro), Papain-like protease (PLpro), helicase (nsp13), RNA-dependent RNA polymerase (nsp12), 2’-O-ribose methyltransferase (nsp16) of SARS-CoV-2 and DNA-PK and CK2alpha in human. The order of affinity for CoV proteins is 5Y3E > 6NUS > 6JYT > 2XYR > 3VB6. Finally, medicinal plants with phytochemicals such as caffeine, ellagic acid, quercetin and their derivatives could possibly remediate COVID-19. Communicated by Ramaswamy H. Sarma
Does chlorhexidine improve outcomes in non-surgical management of peri-implant mucositis or peri-implantitis?: a systematic review and meta-analysis

Background With greater number of implants being placed in clinical practice, incidence of peri-implant diseases are on the rise. It is not known whether chlorhexidine (CHX) improves outcomes in the management of peri-implant diseases. The aim of this systematic review and meta-analysis was to evaluate the role of CHX in improving outcomes with non-surgical management of peri-implant mucositis and peri-implantitis. Material and Methods An electronic search of PubMed, Scopus, Embase, and CENTRAL (Cochrane Central Register of Controlled Trials) databases up to 1st August 2019 was carried out to search for studies evaluating the efficacy of CHX for non-surgical management of peri-implant diseases. Results Seven studies were included. Four studies evaluated the role of CHX in peri-implant mucositis and three in peri-implantitis. Oral prophylaxis with mechanical cleansing of implant surface prior to CHX use was carried out in all seven studies. Meta-analysis indicated that use of CHX did not improve probing depths in peri-implant mucositis (SMD= 0.11; 95% CI: -0.16 to 0.38; p=0.42, I2= 0%). Similarly, CHX did not significantly reduce probing depths in patients with peri-implantitis (MD= 1.57; 95% CI: -0.88 to 4.0; p=0.21, I2= 98%). Results on the efficacy of CHX in reducing BOP in peri-implantitis are conflicting. Conclusions Results of our study indicate that adjunctive therapy with CHX may not improve outcomes with non-surgical management of peri-implant mucositis. Conclusions with regards to its role in non-surgical management of peri-implantitis cannot be drawn. There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis. Key words:Peri-implant disease, disinfection, dental implants, oral hygiene, chlorhexidine.
Cannabis use in patients with early psychosis is associated with alterations in putamen and thalamic shape

Around half of patients with early psychosis have a history of cannabis use. We aimed to determine if there are neurobiological differences in these the subgroups of persons with psychosis with and without a history of cannabis use. We expected to see regional deflations in hippocampus as a neurotoxic effect and regional inflations in striatal regions implicated in addictive processes. Volumetric, T1w MRIs were acquired from people with a diagnosis psychosis with (PwP + C = 28) or without (PwP − C = 26) a history of cannabis use; and Controls with (C + C = 16) or without (C − C = 22) cannabis use. We undertook vertex‐based shape analysis of the brainstem, amygdala, hippocampus, globus pallidus, nucleus accumbens, caudate, putamen, thalamus using FSL FIRST. Clusters were defined through Threshold Free Cluster Enhancement and Family Wise Error was set at p < . 05. We adjusted analyses for age, sex, tobacco and alcohol use. The putamen (bilaterally) and the right thalamus showed regional enlargement in PwP + C versus PwP − C. There were no areas of regional deflation. There were no significant differences between C + C and C − C. Cannabis use in participants with psychosis is associated with morphological alterations in subcortical structures. Putamen and thalamic enlargement may be related to compulsivity in patients with a history of cannabis use.
"Computing" Requirements for Open Source Software: A Distributed Cognitive Approach

Most requirements engineering (RE) research has been conducted in the context of structured and agile software development. Software, however, is increasingly developed in open source software (OSS) forms which have several unique characteristics. In this study, we approach OSS RE as a sociotechnical, distributed cognitive process where distributed actors “compute” requirements— i.e., transform requirements-related knowledge into forms that foster a shared understanding of what the software is going to do and how it can be implemented. Such computation takes place through social sharing of knowledge and the use of heterogeneous artifacts. To illustrate the value of this approach, we conduct a case study of a popular OSS project, Rubinius—a runtime environment for the Ruby programming language—and identify ways in which cognitive workload associated with RE becomes distributed socially, structurally, and temporally across actors and artifacts. We generalize our observations into an analytic framework of OSS RE, which delineates three stages of requirements computation: excavation, instantiation, and testing-in-the-wild. We show how the distributed, dynamic, and heterogeneous computational structure underlying OSS development builds an effective mechanism for managing requirements. Our study contributes to sorely needed theorizing of appropriate RE processes within highly distributed environments as it identifies and articulates several novel mechanisms that undergird cognitive processes associated with distributed forms of RE.
No Evidence for a Trade-Off Between Competitive Traits and Ejaculate Quality in Humans

Research in nonhuman animals (including insects, birds, and primates) suggests a trade-off in males between investment in competitive traits and investment in ejaculate quality. Previous research reported a negative association between perceived strength and ejaculate quality, suggesting that this trade-off also applies to human males. We conducted novel analyses of data secured as part of a larger project to assess the relationship between competitive traits (shoulder-to-hip ratio, handgrip strength, and height) and ejaculate quality (indexed by sperm morphology, sperm motility, and sperm concentration) in a sample of 45 men (ages ranging 18–33 years; M = 23.30, SD = 3.60). By self-report, participants had not had a vasectomy and had never sought treatment for infertility. We controlled for several covariates known to affect ejaculate quality (e.g., abstinence duration before providing an ejaculate) and found no statistically significant relationships between competitive traits and ejaculate quality; our findings therefore do not accord with previous research on humans. We highlight the need for additional research to clarify whether there is a trade-off between investment in competitive traits and investment in ejaculate quality in humans.
Altered effective connectivity from the pregenual anterior cingulate cortex to the laterobasal amygdala mediates the relationship between internet gaming disorder and loneliness

Abstract Background Individual with internet gaming disorder (IGD) often experience a high level of loneliness, and neuroimaging studies have demonstrated that amygdala function is associated with both IGD and loneliness. However, the neurobiological basis underlying these relationships remains unclear. Methods In the current study, Granger causal analysis was performed to investigate amygdalar subdivision-based resting-state effective connectivity differences between 111 IGD subjects and 120 matched participants with recreational game use (RGUs). We further correlated neuroimaging findings with clinical measures. Mediation analysis was conducted to explore whether amygdalar subdivision-based effective connectivity mediated the relationship between IGD severity and loneliness. Results Compared with RGUs, IGD subjects showed inhibitory effective connections from the left pregenual anterior cingulate cortex (pACC) to the left laterobasal amygdala (LBA) and from the right medial prefrontal cortex (mPFC) to the left LBA, as well as an excitatory effective connection from the left middle prefrontal gyrus (MFG) to the right superficial amygdala. Further analyses demonstrated that the left pACC-left LBA effective connection was negatively correlated with both Internet Addiction Test and UCLA Loneliness scores, and it mediated the relationship between the two. Conclusion IGD subjects and RGUs showed different connectivity patterns involving amygdalar subdivisions. These findings support a neurobiological mechanism for the relationship between IGD and loneliness, and suggest targets for therapeutic approaches that could be used to treat IGD.
Does Updated Compared to Older Fluoroscopic Imaging Technology Reduce Radiation Dose During Interventional Spine Procedures? A Pragmatic Cohort Study.

Abstract Objective: Determine if an updated model compared to an older model of a common fluoroscope reduces radiation dose during interventional spine procedures. Methods: Retrospective cohort study containing patients who underwent fluoroscopically-guided spine procedures between April 2016-December 2016. Multivariate regression analysis performed to examine the mean radiation dose during various interventional spine procedures using a GE OEC 9800 and GE OEC 9900 machine. Age, sex, BMI, spinal level, trainee presence, and fluoroscopy time was used as covariates in order to control for possible confounding variations in patient demographics and procedure characteristics before and after implementation of the new fluoroscope. Results: Total of 271 injection encounters(male=43.9%, age=58.6 ±13.4 years, BMI=29.0 ±6.8 kg/m2) were analyzed. There was no significant difference in radiation dose per procedure between the machines(2779 ±3158 mGycm2vs.2626 ±3147 mGycm2,p=0.689). The mean fluoroscopy dose per procedure was significantly higher for lumbar compared to cervical injections(3778 ±3736 mGycm2vs.1267 ±968 mGycm2,p 0.05). Higher BMI and longer fluoroscopy time were significantly associated with greater radiation dose(p<0.001). Conclusion: Radiation dose exposure during fluoroscopically-guided interventional spine/pain procedures was not significantly different when comparing an older- and newer-generation fluoroscope; this remained true after controlling for possible confounding variables.
Lipid profiling, carbon partitioning, and inorganic carbon optimization to enhance growth and lipid accumulation in microalgae

Microalgae are capable of accumulating high concentrations of lipids and other metabolites which can be used as precursor compounds for energy and valuable coproducts. In order to fully exploit this resource, robust methods are needed to properly quantify and analyze the metabolites of interest. Additionally, understanding how and why these organisms synthesize these metabolites and developing optimized strategies for enhancing their metabolism is of paramount importance if algal biofuels and coproduct development are to become commercially feasible. This dissertation represents the summary of work completed to develop analytical methods for quantifying lipid compounds synthesized by two Chlorophytes, Chlamydomonas reinhardtii sp. CC124 and Chlorella vulgaris UTEX 395, and the marine diatom Phaeodactylum tricornutum Pt-1. Additionally, C.reinhardtii was evaluated for factors that control and stimulate triacylglycerol (TAG) accumulation in microalgae by monitoring changes in lipid precursor compounds such as free fatty acids, monodiand tri-acylglycerides as well as fatty acids which were transesterified into fatty acid methyl ester (FAME); the biosynthesized equivalent of diesel fuel. C. vulgaris was evaluated for optimized growth and lipid accumulation on various inorganic carbon substrates. This work resulted in a commercially applicable, two-phase growth/lipid accumulation regime which uses low grade sodium bicarbonate as the inorganic carbon substrate to enhance both growth and lipid accumulation and reduce the cost and resource overhead associated with using only carbon dioxide as the sole inorganic carbon source.
The choroid plexus stroma constitutes a sanctuary for paediatric B‐cell precursor acute lymphoblastic leukaemia in the central nervous system

Despite current central nervous system‐directed therapies for childhood B‐cell precursor acute lymphoblastic leukaemia, relapse at this anatomical site still remains a challenging issue. Few reports have addressed the study of the specific cellular microenvironments which can promote the survival, quiescence, and therefore chemoresistance of B‐cell precursor acute lymphoblastic leukaemia cells in the central nervous system. Herein, we showed by immunofluorescence and electron microscopy that in xenotransplanted mice, leukaemic cells infiltrate the connective tissue stroma of the choroid plexus, the brain structure responsible for the production of cerebrospinal fluid. The ultrastructural study also showed that leukaemia cells are able to migrate through blood vessels located in the choroid plexus stroma. In short‐term co‐cultures, leukaemic cells established strong interactions with human choroid plexus fibroblasts, mediated by an increased expression of ITGA4 (VLA‐4)/ITGAL (LFA‐1) and their ligands VCAM1/ICAM1. Upon contact with leukaemia cells, human choroid plexus fibroblasts acquired a cancer‐associated fibroblast phenotype, with an increased expression of α‐SMA and vimentin as well as pro‐inflammatory factors. Human choroid plexus fibroblasts also have the capacity to reduce the proliferative index of leukaemic blasts and promote their survival and chemoresistance to methotrexate and cytarabine. The inhibition of VLA‐4/VCAM‐1 interactions using anti‐VLA‐4 antibodies, and the blockade of Notch signalling pathway by using a γ‐secretase inhibitor partially restored chemotherapy sensitivity of leukaemia cells. We propose that the choroid plexus stroma constitutes a sanctuary for B‐cell precursor acute lymphoblastic leukaemia cells in the central nervous system. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.
Effect of husked and naked oat used in the diets supplemented with linseed oil on the growth performance of pigs, carcass and meat quality

aim of the experiment was to determine the effects of husked and naked oat grain used in the diets supplemented with oils, but not supplemented with vitamin E and selenium, on the meat quality and fattening results of pigs. 24 crossbred barrows were fed individually, from approx. 40 to 104 kg BW. The control diet (C) contained triticale and two experimental diets contained either 45% of husked oat (O) or 45% of naked oat (NO). The diets were formulated as prooxidative, i.e. they were supplemented with 3% of linseed oil and 1% of rapeseed oil during the grower period, as well as with 3% of linseed oil during the finisher period. All diets were isolipidic and isofibrous. Growth performance, carcass quality, as well as the pH, chemical composition, fatty acids, drip loss, color (L*, a*, b*), sensory properties, the content of vitamin E, vitamin A and TBARS in longissimus dorsi (LM) samples were determined. The experimental treatments had no effect on growth performance, meatiness, and contents of protein and fat in LM samples. Meat from pigs fed the diet with husked oat had a more desirable color (L*) than meat from pigs fed the control diet or the diet with naked oat. After 96 hours of storage at 4°C LM samples of pigs given the diet with naked oat had lower (P>0.05) drip loss (6.49%), as of pigs fed diets with husked oat (7.30%) or triticale (8.21%). Naked oat significantly increased the oxidative stability of meat, measured based on the formation of TBARS.