Miracle-dz/UniFAR-FTUs huggingface dataset:
miR‐96‐5p regulates cervical cancer cell resistance to cisplatin by inhibiting lncRNA TRIM52‐AS1 and promoting IGF2BP2

MicroRNA (miRNA) and long noncoding RNA (lncRNA) are both regulators of cancer progression. This study sought to discuss the functional mechanism of miR‐96‐5p/lncRNA TRIM52 antisense RNA 1 (head‐to‐head; TRIM52‐AS1) in cervical cancer (CC) cell resistance to cisplatin (DDP). DDP‐resistant CC cell line was established using increasing concentrations of DDP, followed by transfection with miR‐96‐5p inhibitor, or si‐TRIM52‐AS1, or insulin‐like growth factor 2 mRNA binding protein 2 (IGF2BP2) overexpression vector. Expression levels of miR‐96‐5p, TRIM52‐AS1, and IGF2BP2 were determined. Changes in IC50 value to DDP, cell proliferation, and apoptosis rate were evaluated by cell‐counting kit‐8 assay, colony formation, and flow cytometry. The bindings of miR‐96‐5p to IGF2BP2 and TRIM52‐AS1 to IGF2BP2 were verified by dual‐luciferase or RNA pull‐down assays. These experiments revealed an up‐expression of miR‐96‐5p and IGF2BP2 while an under‐expression of TRIM52‐AS1 in CC cells. After DDP treatment, miR‐96‐5p inhibition increased apoptosis and decreased proliferation and DDP resistance. miR‐96‐5p bound to TRIM52‐AS1 and downregulated TRIM52‐AS1 expression, and TRIM52‐AS1 bound to IGF2BP2 to inhibit IGF2BP2 expression. TRIM52‐AS1 inhibition or IGF2BP2 overexpression neutralized the inhibition of silencing miR‐96‐5p on CC cell resistance to DDP. Overall, miR‐96‐5p improved CC cell resistance to DDP by inhibiting TRIM52‐AS1 and promoting IGF2BP2.
Electronic and magnetic properties of the interface LaAlO 3 /TiO 2 anatase from density functional theory

Ab initio calculations using the local spin density approximation and also including the Hubbard U have been performed for three low-energy configurations of the interface between LaAlO3 and TiO2 anatase. Two types of interfaces have been considered: LaO/TiO2 and AlO2/TiO, the latter with Ti termination and therefore a missing oxygen. A slab-geometry calculation was carried out, and all the atoms were allowed to relax in the direction normal to the interface. In all the cases considered, the interfacial Ti atom acquires a local magnetic moment, and its formal valence is less than +4. When there are oxygen vacancies, this valence decreases abruptly inside the anatase slab, while in the LaO/TiO2 interface, the changes are more gradual.
Nearby low-luminosity GRBs as the sources of ultra-high energy cosmic rays revisited

Low-luminosity gamma-ray bursts (GRBs) with luminosity . 10^49erg/s probably consititute a distinct population from the classic high-luminosity GRBs. They are the most luminous objects detected so far within ~ 100 Mpc, the horizon distance of ultra-high energy cosmic rays (UHECRs), so they are considered to be candidate sources of UHECRs. It was recently argued that the energy production rate in UHECRs is much larger than that in gamma-ray photons of long GRBs measured by the Fermi satellite, which, if true, would challenge the view that GRBs can be the sources of UHECRs. We here suggest that many of the low luminosity GRBs, due to their low luminosity, can not trigger the current GRB detectors and hence their contribution to the local gamma-ray energy production rate is missing. We find that the real local energy production rate by low-luminosity GRBs, taking into account the missing part, which constitutes a dominant fraction of the total amount, could be sufficient to account for the flux of UHECRs. Due to the low-luminosity, only intermediate-mass or heavy nuclei can be accelerated to ~ 10^20 eV. We discuss the acceleration and survival of these UHE nuclei in low-luminosity GRBs, especially in those missing low-luminosity GRBs. At last, the accompanying diffuse neutrino flux from the whole low-luminosity GRB population is calculated.
The effects of normobaric and hypobaric hypoxia on cognitive performance and physiological responses: A crossover study

This partially randomised controlled, crossover study sought to investigate the effects of normobaric hypoxia (NH) and hypobaric hypoxia (HH) on cognitive performance, the physiological response at rest and after a 3-min step-test. Twenty healthy participants (10 females and 10 males, 27.6±6.2yrs, 73.6±13.7kg, 175.3±8.9cm) completed a cognitive performance test, followed by the modified Harvard-step protocol, in four environments: normobaric normoxia (NN; PiO2: 146.0±1.5mmHg), NH (PiO2: 100.9±1.3mmHg), HH at the first day of ascent (HH1: PiO2 = 105.6±0.4mmHg) and HH after an overnight stay (HH2: PiO2 = 106.0±0.5mmHg). At rest and/or exercise, SpO2, NIRS, and cardiovascular and perceptual data were collected. The cerebral tissue oxygenation index and the cognitive performance (throughput, accuracy, and reaction time) were not different between the hypoxic conditions (all p>0.05). In NH, SpO2 was higher compared to HH1 (ΔSpO2 NH vs HH1: 1.7±0.5%, p = 0.003) whilst heart rate (ΔHR NH vs HH2: 5.8±2.6 bpm, p = 0.03) and sympathetic activation (ΔSNSi NH vs HH2: 0.8±0.4, p = 0.03) were lower in NH compared to HH2. Heart rate (ΔHR HH1 vs HH2: 6.9±2.6 bpm, p = 0.01) and sympathetic action (ΔSNSi HH1 vs HH2: 0.9±0.4, p = 0.02) were both lower in HH1 compared to HH2. In conclusion, cognitive performance and cerebral oxygenation didn’t differ between the hypoxic conditions. SpO2 was only higher in NH compared to HH1. In HH2, heart rate and sympathetic activation were higher compared to both NH and HH1. These conclusions account for a PiO2 between 100–106 mmHg.
Antimalarial and Plasmodium falciparum serpentine receptor 12 targeting effect of FDA approved purinergic receptor antagonist

Abstract Intraerythrocytic stages of Plasmodium falciparum responsible for all clinical manifestations of malaria are regulated by array of signalling cascades that represent attractive targets for antimalarial therapy. G-protein coupled receptors (GPCRs) are druggable targets in the treatment of various pathological conditions, however, there is limited understanding about the role of GPCRs in malaria pathogenesis. In Plasmodium, serpentine receptors (PfSR1, PfSR10, PfSR12 and PfSR25) with GPCR-like membrane topology have been reported with the finite knowledge about their potential as antimalarial targets. We analyzed the localization of these receptors in malaria parasite by immunofluorescence assays. All four receptors were expressed in blood stages with PfSR12 expressing more in late intraerythrocytic stages. Further, we evaluated the druggability of PfSR12 using FDA-approved P2Y purinergic receptor antagonist, Prasugrel and its active metabolite R138727, which is proposed to be specific towards PfSR12. Interestingly, biophysical analysis indicated strong binding between PfSR12 and R138727 as compared to the prodrug Prasugrel. This binding interaction was further confirmed by thermal shift assay. Treatment of parasite with Prasugrel and R138727 resulted in growth inhibition of P. falciparum indicating an important role of purinergic signalling and PfSR12 in parasite survival. Next, progression studies indicated the inhibitory effect of Prasugrel begins in late erythrocyte stages corroborating with PfSR12 expression at these stages. Furthermore, Prasugrel also blocked in vivo growth of malaria parasite in a mouse experimental model. This study indicates the presence of P2Y type of purinergic signalling in growth and development of malaria parasite and suggests PfSR12, putative purinergic receptor druggability through Prasugrel. Communicated by Ramaswamy H. Sarma
PROBABLE SPIN–ORBIT ALIGNED SUPER-EARTH PLANET CANDIDATE KOI2138

We use rotational gravity darkening in the disk of Kepler star KOI-2138 to show that the orbit of 2.1 − R ⨁ ? > transiting planet candidate KOI-2138.01 has a low projected spin–orbit alignment of λ = 1 ° ± 13 ° ? > . KOI-2138.01 is just the second super-Earth with a measured spin–orbit alignment after 55 Cancri e, and the first to be aligned. With a 23.55 days orbital period, KOI-2138.01 may represent the tip of a future iceberg of solar-system-like terrestrial planets having intermediate periods and low-inclination circular orbits.
Phase diagram and nucleation in the Polyakov-loop-extended Quark-Meson truncation of QCD with the unquenched Polyakov-loop potential

Unquenching of the Polyakov-loop potential showed to be an important improvement for the description of the phase structure and thermodynamics of strongly-interacting matter at zero quark chemical potentials with Polyakov-loop extended chiral models. This work constitutes the first application of the quark backreaction on the Polyakov-loop potential at nonzero density. The observation is that it links the chiral and deconfinement phase transition also at small temperatures and large quark chemical potentials. The build up of the surface tension in the Polyakov-loop extended Quark-Meson model is explored by investigating the two and 2+1-flavour Quark-Meson model and analysing the impact of the Polyakov-loop extension. In general, the order of magnitude of the surface tension is given by the chiral phase transition. The coupling of the chiral and deconfinement transition with the unquenched Polyakov-loop potential leads to the fact that the Polyakov-loop contributes at all temperatures.
Rapid Bacteria Detection from Patients’ Blood Bypassing Classical Bacterial Culturing

Sepsis is a life-threatening condition mostly caused by a bacterial infection resulting in inflammatory reaction and organ dysfunction if not treated effectively. Rapid identification of the causing bacterial pathogen already in the early stage of bacteremia is therefore vital. Current technologies still rely on time-consuming procedures including bacterial culturing up to 72 h. Our approach is based on ultra-rapid and highly sensitive nanomechanical sensor arrays. In measurements we observe two clearly distinguishable distributions consisting of samples with bacteria and without bacteria respectively. Compressive surface stress indicates the presence of bacteria. For this proof-of-concept, we extracted total RNA from EDTA whole blood samples from patients with blood-culture-confirmed bacteremia, which is the reference standard in diagnostics. We determined the presence or absence of bacterial RNA in the sample through 16S-rRNA hybridization and species-specific probes using nanomechanical sensor arrays. Via both probes, we identified two clinically highly-relevant bacterial species i.e., Escherichia coli and Staphylococcus aureus down to an equivalent of 20 CFU per milliliter EDTA whole blood. The dynamic range of three orders of magnitude covers most clinical cases. We correctly identified all patient samples regarding the presence or absence of bacteria. We envision our technology as an important contribution to early and sensitive sepsis diagnosis directly from blood without requirement for cultivation. This would be a game changer in diagnostics, as no commercial PCR or POCT device currently exists who can do this.
The evolution of luminosity, colour, and the mass-to-luminosity ratio of Galactic open clusters - Comparison of discrete vs. continuous IMF models

Context. We found in previous studies that standard simple stellar population (SSP) models are unable to describe or explain the colours of Galactic open clusters both in the visible and in the near-infrared (NIR) spectral range. The reason for this disagreement is the continuous nature of the stellar initial mass function (IMF) in clusters, which is the underlying assumption in the SSP models. In reality, the Galactic open clusters are sparsely populated with the brightest stars responsible for integrated fluxes. Aims. In this study, we aim at constructing discrete SSP-models that are able to adequately describe the observed magnitude-, colour-, and mass-to-luminosity-ratio-age relations of open clusters by including a number of seldom considered effects. Methods. We construct a numerical SSP-model with an underlying Salpeter IMF, which is valid within an upper mu and lower ml
Revealing the origin of super Efimov states in the hyperspherical formalism

Super-Efimov states are a new kind of universal three-body bound states predicted for three identical fermions with $p$-wave resonant interactions in two dimensions by a recent field-theoretic calculation [Phys.~Rev.~Lett. ~\textbf{110}, 235301 (2013)]. The binding energies of these states obey a dramatic double exponential scaling $E_n=E_*\exp(-2 e^{\pi n/s_0+\theta})$ with universal scaling $s_0=4/3$ and three-body parameters $E_*$ and $\theta$. We use the hyperspherical formalism and show that the super-Efimov states originate from an emergent effective potential $-1/4\rho^2-(s_0^2+1/4)/\rho^2\ln^2\left(\rho\right)$ at large hyperradius $\rho$. Moreover, for pairwise interparticle potentials with van der Waals tails, our numerical calculation indicates that the three-body parameters $E_*$ and $\theta$ are also universal and the ground super-Efimov state shall cross the threshold when the $2$D $p$-wave scattering area is about $-42.0\, l_\text{vdW}^2$ with $l_\text{vdW}$ the van der Waals length.
Missing dark matter in dwarf galaxies

We use cosmological hydrodynamical simulations of the APOSTLE project to examine the fraction of baryons in CDM haloes that collect into galaxies. This ‘galaxy formation efficiency’ correlates strongly and with little scatter with halo mass, dropping steadily towards dwarf galaxies. The baryonic mass of a galaxy may thus be used to place a lower limit on total halo mass and, consequently, on its asymptotic maximum circular velocity. A number of dwarfs seem to violate this constraint, having baryonic masses up to ten times higher than expected from their rotation speeds, or, alternatively, rotating at only half the speed expected for their mass. Taking the data at face value, either these systems have formed galaxies with extraordinary efficiency ‐ highly unlikely given their shallow potential wells ‐ or they inhabit haloes with extreme deficits in their dark matter content. This ‘missing dark matter’ is reminiscent of the inner mass deficits of galaxies with slowly-rising rotation curves, but extends to regions larger than the luminous galaxies themselves, disfavouring explanations based on star formationinduced ‘cores’ in the dark matter. An alternative could be that galaxy inclination errors have been underestimated, and that these are just systems where inferred mass profiles have been compromised by systematic uncertainties in interpreting the velocity field. This should be investigated further, since it might provide a simple explanation not only for missing-dark-matter galaxies but also for other challenges to our understanding of the inner structure of cold dark matter haloes.
BLACK HOLE MASS AND BULGE LUMINOSITY FOR LOW-MASS BLACK HOLES

We study the scaling between bulge magnitude and central black hole (BH) mass in galaxies with virial BH masses ≲ 106 M☉. Based on careful image decomposition of a snapshot Hubble Space Telescope I-band survey, we found that these BHs are found predominantly in galaxies with pseudobulges. Here we show that the MBH–Lbulge relation for the pseudobulges at low mass is significantly different from classical bulges with BH masses ⩾107 M☉. Specifically, bulges span a much wider range of bulge luminosity, and on average the luminosity is larger, at fixed MBH. The trend holds both for the active galaxies from Bentz et al. and the inactive sample of Gültekin et al. and cannot be explained by differences in stellar populations, as it persists when we use dynamical bulge masses. Put another way, the ratio between bulge and BH mass is much larger than ∼1000 for our sample. This is consistent with recent suggestions that MBH does not scale with the pseudobulge luminosity. The low-mass scaling relations appear to flatten, consistent with predictions from Volonteri & Natarajan for massive seed BHs.
Rapidly rotating neutron stars in scalar-tensor theories of gravity

We present the field equations governing the equilibrium of rapidly rotating neutron stars in scalar-tensor theories of gravity, as well as representative numerical solutions. The conditions for the presence of a nontrivial scalar field and the deviations from the general relativistic solutions are studied. Two examples of scalar-tensor theories are examined - one case that is equivalent to the Brans-Dicke theory and a second case, that is perturbatively equivalent to Einstein's General Relativity in the weak field regime, but can differ significantly for strong fields. Our numerical results show that rapidly rotating neutron star models with a nontrivial scalar field exist in both cases and that the effect of the scalar field is stronger for rapid rotation. If we consider values of the coupling parameters in accordance with current observations, only the second example of scalar-tensor theories has significant influence on the neutron star structure. We show that scalarized, rapidly rotating neutron stars exist for a larger range of the parameters than in the static case, since a nontrivial scalar field is present even for values of the coupling constant $\beta>-4.35$, and that these solutions are energetically more favorable than the general relativistic ones. In addition, the deviations of the rapidly rotating scalar-tensor neutron stars from the general-relativistic solutions is significantly larger than in the static case.
One size does not fit all: Influence of sex and maturation on temporal-spatial parameters for adolescent long-distance runners

ABSTRACT Runners and coaches are often interested in identifying the “ideal” running form to reduce the risk of injury and improve performance. While differences in pelvis and hip motion have been reported among adolescent female and male long-distance runners of different stages of physical maturation, the influence of sex and/or maturation on temporal-spatial parameters is unknown for adolescent runners. Adolescent runners of different stages of physical maturation (pre-, mid-, post-pubertal) completed an overground running analysis at a self-selected speed. We performed 2 × 3 ANCOVAs (covariate = running speed) to compare temporal-spatial parameters among sex and maturation groups. Pre-adolescents ran with higher cadences and shorter step lengths than mid- (p ≤ .01) and post-pubertal adolescents (p ≤ .01), respectively. Mid-pubertal males and post-pubertal females also ran with higher cadences and shorter step lengths than post-pubertal males (p ≤ .01). When step length was normalized to leg length, less physically mature runners demonstrated longer normalized step lengths (p ≤ .01). Caution is advised when using a “one-size-fits-all” approach for recommending an “ideal” cadence and/or step length for adolescent long-distance runners. A runner’s sex, stage of physical maturation and leg length should be considered when assessing and prescribing cadence and/or step length.
The impact of burnout on turnover intention among Chinese general practitioners: The mediating effect of job satisfaction and the moderating effect of professional identity

Background: Turnover among general practitioners (GPs) has become a significant public health concern worldwide. Aims: This study aimed to investigate the interrelationships between job satisfaction, professional identity, burnout, and turnover intention among GPs in China and to assess the mediating effect of job satisfaction on the association between burnout and turnover intention and the moderating effect of professional identity on the association between burnout and job satisfaction. Method: A cross-sectional study was conducted to collect data from 3,236 GPs in eastern, central, and western China between October 2017 and February 2018 using a self-administered questionnaire. Pearson’s correlation analysis and hierarchical regression were used to identify the relationships between job satisfaction, professional identity, burnout, and turnover intention among Chinese GPs. Results: Among these respondents, 65.02% reported a medium or high level of emotional exhaustion (EE), 35.38% reported a moderate or high level of depersonalization (DP), and 62.05% reported reduced personal achievement (PA). Overall, 71.08% of GPs expressed a relatively high intention to seek another position (turnover intention). We found all 3 dimensions of burnout contributed to job dissatisfaction while turnover intention arising from burnout was associated with EE and DP. Job satisfaction had a direct negative impact on turnover intention and partially mediated the impact of EE and DP on turnover intention. Professional identity played a partial moderated role between EE and job satisfaction. Conclusions: The prevalence of burnout and turnover intention among GPs is high in China. The effect of EE and DP on turnover intention is mediated by job satisfaction, and the effect of EE on job satisfaction is moderated by professional identity.
MASSIVE HALOS IN MILLENNIUM GAS SIMULATIONS: MULTIVARIATE SCALING RELATIONS

The joint likelihood of observable cluster signals reflects the astrophysical evolution of the coupled baryonic and dark matter components in massive halos, and its knowledge will enhance cosmological parameter constraints in the coming era of large, multiwavelength cluster surveys. We present a computational study of intrinsic covariance in cluster properties using halo populations derived from Millennium Gas Simulations (MGS). The MGS are re-simulations of the original 500 h−1 Mpc Millennium Simulation performed with gas dynamics under two different physical treatments: shock heating driven by gravity only (GO) and a second treatment with cooling and preheating (PH). We examine relationships among structural properties and observable X-ray and Sunyaev–Zel'dovich (SZ) signals for samples of thousands of halos with M200 ⩾ 5 × 1013 h−1 M☉ and z < 2. While the X-ray scaling behavior of PH model halos at low redshift offers a good match to local clusters, the model exhibits non-standard features testable with larger surveys, including weakly running slopes in hot gas observable–mass relations and ∼10% departures from self-similar redshift evolution for 1014 h−1 M☉ halos at redshift z ∼ 1. We find that the form of the joint likelihood of signal pairs is generally well described by a multivariate, log-normal distribution, especially in the PH case which exhibits less halo substructure than the GO model. At fixed mass and epoch, joint deviations of signal pairs display mainly positive correlations, especially the thermal SZ effect paired with either hot gas fraction (r = 0.88/0.69 for PH/GO at z = 0) or X-ray temperature (r = 0.62/0.83). The levels of variance in X-ray luminosity, temperature, and gas mass fraction are sensitive to the physical treatment, but offsetting shifts in the latter two measures maintain a fixed 12% scatter in the integrated SZ signal under both gas treatments. We discuss halo mass selection by signal pairs, and find a minimum mass scatter of 4% in the PH model by combining thermal SZ and gas fraction measurements.