Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and multi-objective optimization of a magnetohydrodynamic drug delivery infusion micropump

: Continuous drug infusion plays an important role in drug effectiveness. However, in most cases, the size, weight and power consumption of the conventional pumps are among the most important factors that cause a lot of problems for the patient comfort. The present work aims to design and optimize a Magneto hydrodynamic micro pump for continuous drug infusion. A mathematical model of Magneto hydrodynamic micro pump is proposed and solved analytically to investigate its feasibility for drug infusion. For the patient's comfort, the micro pump is optimized using non-dominated sorting genetic algorithm II. The number of channel rows and columns, channel height and width, and driving voltage are chosen as decision variables for multi-objective optimization. The Pareto front of the optimization result is presented. Six possible cases that meet the desired specifications are selected using a fuzzy decision-making approach. A computational fluid dynamic model is adopted to predict bubble formation due to the electrolysis phenomena. With higher reliability without any mechanical part, the present design can deliver drug flow 48 times while its driving voltage is 3 times lower than a conventional micro pump. In addition, it provides potentially better reliability and a simple fabrication process without any mechanical part.
Effects of Cage Pocket Shapes on Dynamics of Angular Contact Ball Bearings

The dynamic models of spherical and cylindrical pocket cages are established based on the dynamic wear simulation model of angular contact ball bearings, and the predicted results are in reasonable agreement with the experimental observations. In this paper, the effects of cage pocket shapes on dynamics of angular contact ball bearings in different pocket clearance are studied based on the established model. It is found that the whirl range of the cylindrical pocket cage is limited by guiding ring, and for spherical pocket cage is limited by balls. And the cage motion of spherical pocket is more stable than that of cylindrical pocket. The stability of the cage is positively related to the stability of the ball's distribution. Meanwhile, the axial swing range of the cage is related to the angle of the ball/cage pocket collision point. In addition, due to the sliding between the balls and the raceways, the bearing friction moment of the spherical pocket cage is larger, and the bearing friction moment of the cylindrical pocket cage is highly transient due to the unstable movement of the cage.
Characterization of Shale Pore Structure by Multitechnique Combination and Multifractal Analysis and Its Significance

Understanding pore structure would enable us to obtain a deeper insight into the fluid mechanism in porous media. In this research, multifractal analysis by various experiments is employed to analyze the pore structure and heterogeneity characterization in the source rock in Ordos Basin, China. For this purpose, imaging apparatus, intrusion tests, and nonintrusion methods have been used. The results show that the objective shale reservoir contains complex pore network, and minor pores dominant the pore system. Both intrusion and nonintrusion methods detected pore size distributions show multifractal nature, while the former one demonstrates more heterogeneous features. The pore size distributions acquired by low temperature adsorption and nuclear magnetic resonance have relatively good consistence, indicating that similar pore network detection method may share the same mechanism, and the full-ranged pore size distributions need to be acquired by multitechniques. Chlorite has an obvious impact on the heterogeneity of pore structure in narrow pore size range, while illite and I/S mixed layer influence that in wide range. Kerogen index is the fundamental indicators of geochemical parameters. With the decrease of averaged small and middle/large pore radius, the heterogeneity of pore structures increase in narrow and wide ranges, respectively. This work employed a comprehensive methodology based on multitechniques and helps to explore how pore networks affect reservoir quality in shale reservoirs.
Are Drug Efflux Genes Present among Mycobacterium tuberculosis Isolates from Patients in Lagos, Nigeria?

A major challenge in the treatment of Tuberculosis (TB) is emergence of Multi-Drug Resistant Mycobacterium tuberculosis (MDRTB) strains. Efflux genes have been established to be among factors for drug resistance in Mycobacterium tuberculosis (M. tuberculosis) pulmonary infections by conferring bacterial ability to pump-out drugs from intracellular compartment, making it impossible for drugs to attain intracellular concentration lethal to the organism. There is paucity of data on the role of efflux pump in MDRTB in Nigerian strains of M. tuberculosis. Hence, the aim of this study was to detect the carriage, distribution and frequency of efflux pump genes among MDRTB and non-MDRTB isolates from participants with pulmonary tuberculosis in Lagos, Nigeria. This study was carried out on M. tuberculosis isolated from 1020 participants suspected of pulmonary tuberculosis in Lagos State, Nigeria. A total of 78 M. tuberculosis isolates were obtained from the participants suspected of pulmonary tuberculosis. Forty Eight isolates were confirmed as MDRTB and 30 non-MDRTB. Efflux pump genes were investigated in the isolates using the conventional polymerase chain reaction. Statistical analysis was carried out using the Statistical Package for Social Science (SPSS version 20) to compare the efflux pump gene results between MDRTB and non- MDRTB isolates. Different efflux genes types and frequency were detected in MDRTB and non-MDRTB isolates. Carriage of 2 or more alleles of efflux gene types Rv2486c (efpA), Rv2459c (jefA), Rv1877, Rv1002c, Rv0342, Rv2686c and drrC associated with MDR were detected. Additionally, the frequency of efflux genes alleles in MDRTB was significantly different from those in non- MDRTB isolates.
The Short-Term Impact of Different Silvicultural Thinnings on Soil Nematode and Microarthropod Biodiversity in Artificial Black Pine Stands

Soil invertebrates represent almost a quarter of the total diversity of living organisms and their activity affects the entire soil ecological process. The choice of adequate thinning systems may differently affect soil nematode and microarthropod biodiversity in artificial black pinewoods. In this work, the results of the impact of different thinnings on the structure of nematode and microarthropod communities was reported. In a short-term experiment, thinning from below and selective thinning were compared to unmanaged stands to provide indications at the regional scale in central Italy. Soil nematode and microarthropod biodiversity was explored by examining community structure, assessing biodiversity. The interaction between environmental variables (crown volume, Photosynthetically Active Radiation, soil texture, soil temperature, and moisture) with taxa abundance of nematodes and microarthropods were also reported. The results indicated that the effects of thinning practices were temporary and varied between years. Soil nematode community shifted during the first and third years of thinning managements only in the Pratomagno site, while soil microarthropod community shifted in both sites only in the second year. The total nematode abundance was minimally affected by thinning practices, while the nematode community composition showed a decrease of omnivores and predators in the first years. Soil indicators showed inconsistent results. In microarthropods, mites and collembola were the least affected by thinning in terms of abundance and species biodiversity, while eu-edaphic taxa of Chilopoda, Diplopoda, and Pauropoda were not influenced by thinning, hemi-edaphic and epi-edaphic taxa of Coleoptera, Diptera, Hymenoptera, Tysanoptera, and Hemiptera were negatively affected. Soil indicators such as Shannon-Weiner and Simpson indices and soil biological quality (QBS-ar) improved in thinning from below in both sites. Soil temperature and moisture were the main driving factors in affecting soil nematode and microarthropods communities. Thinning from below probably allowed a more rapid recovery than selective thinning.
Effect of aspect ratio on the recirculation region of 35° Ahmed body

ABSTRACT This paper reports a numerical investigation of the effect of aspect ratio (AR) on the flow structure around the 35° Ahmed body. The AR is defined as the ratio of length to the height of the model. A total of five ARs are considered at a Reynolds number based on the height of the Ahmed body of 7.8 105. The flow governing equations are solved in the FLUENT solver using the SST K-Omega turbulence model. It is found that the drag coefficient (Cd) slightly increases at the AR1 4.2%. As the aspect ratio increases, the drag coefficient decreases. The analysis reveals that early flow separation in the AR1 causes a reattachment at the rear slant end, which leads to an increase in drag. It also highlights that there exists a minimum aspect ratio beyond which the drag increases. and there is a limit in the increasing order beyond which the drag will begin to reduce. Further, it demonstrates that there is no change in the recirculation region and consequently drag coefficient is not a function of the recirculation region. Thence, a clear understanding of the effect of the length-based aspect ratio can help to optimize the length during design.
Developing geriatric face makeup enrichment book for students of Skin Beauty program in vocational high school

This research aims to: (1) produce a Geriatric Makeup Enrichment book as a teaching material of geriatric makeup for students of Purworejo 3 Vocational High School majoring in Beauty that is feasible and effective . This research is research and development applying the four-D. The product feasibility tests were carried out by two material experts and two media experts by validated the enrichment book through a questionnaire using a Likert scale was analyzed using conversion scores into four quantitative categories then tested the agreement between experts through the Cohen's Kappa test and its effectiveness was tested with a one-group case study technique and analyzed with gain scores. The subjects of this research trial were students of class XI Beauty in Purworejo 3 Vocational High School The data collection instruments used are observation guidelines, interview guidelines, experts’ validation questionnaire, teachers’ response questionnaire, students’ response questionnaire and ability test The research results are as follows. The enrichment book developed met the feasibility criteria according to material experts with a score of 3.59 (excellent) and there was agreement between material expert with a Cohen’s Kappa coefficient of 0.64 (good) Tthen, met the feasibility criteria according to media experts with a score of 3.70 (excellent) and there was an agreement between media with a Cohen’s Kappa coefficient value of 1.00 (excellent). Enrichment book developed was declared effective for use in XI grade students of Purworejo 3 Vocational High School majoring in Beauty and was included in medium category for value understanding with the gain score 0.5 and in a high category in skill value with the gain score 0.71.
PhD trained employees and firms’ transitions to upstream R&D activities

ABSTRACT This paper investigates the relationship between firms’ transition towards upstream-R&D activities and the availability of R&D employees with PhD training. Doctoral trained employees have distinct motivations for research: some have stronger preferences for intellectual freedom and autonomy, while others reveal greater aspirations for targeted research and opportunities for development of new products and processes. These contrasting profiles among PhD trained employees lead to ambiguous predictions about whether a greater presence of employees with a doctoral training enhances the capacity of firms to initiate upstream-oriented R&D. We examine this question by studying a large sample of Spanish manufacturing firms which are active in development activities, and investigate the effect of PhD trained R&D employees on the propensity of firms to initiate upstream-oriented R&D. Our results show that a higher proportion of PhDs in R&D functions has a positive and significant influence on the firm’s initiation of an upstream-oriented R&D strategy.
On the effect of electrostatic surface forces on dielectric falling films

Abstract The destabilization of a dielectric film flow due to an electrostatic surface force is investigated. A weighted residuals integral boundary-layer (WIBL) model is derived and validated against full numerical simulations. The equations of the WIBL model indicate that the electrostatic surface force contributes to the evolution equations in a similar mathematical way as the volumetric gravitational force. Contrary to gravity, an additional electrostatic contribution ($\chi _2$) arises, whose impact increases nonlinearly with decreasing capacitor plate distance. This nonlinear contribution causes a fold of the branch of solutions of the dynamical system and, thus, the co-existence of a low amplitude solution that is stable against infinitesimal disturbances and an unstable high amplitude solution. In time-dependent simulations, the fold coincides with the limit in the parameter space beyond which a finite-time blow-up occurs with an unsaturated growth of the main wave hump leading to wave pinch-off and drop formation. Thus, a phase diagram can be constructed by tracking this fold. The shape of the main wave prior to blow-up depends on the electrostatic parameter $\chi _2$. If this parameter is zero, the force is equivalent to a hanging film flow configuration and dripping occurs with a drop-shaped structure. With an increasing contribution of the parameter $\chi _2$, Taylor-cone waves occur prior to finite-time blow-up, leading to jetting. Finally, the transition from stable to unstable waves is investigated in terms of the two dimensionless electric parameters, the Reynolds, and viscous dissipation numbers. Imposing the most amplified wavelength, a transition border between stable solutions and jetting is identified.
Neuropeptide Y mediates cardiac hypertrophy through microRNA-216b/FoxO4 signaling pathway

Cardiac hypertrophy (CH) is a major risk factor for heart failure accompanied by maladaptive cardiac remodeling. The role and potential mechanism of neuropeptide Y (NPY) in CH are still unclear. We will explore the role and the mechanism of NPY inactivation (NPY-I) in CH caused by pressure overload. Abdominal aortic constriction (AAC) was used to induce CH model in rats. NPY or angiotensin II (Ang II) was used to trigger CH model in vitro in neonatal rat ventricular myocytes (NRVMs). We found that NPY was increased in the heart and plasma of hypertrophic rats. However, Ang II did not increase NPY expression in cardiomyocytes. NPY-I attenuated CH as decreasing CH-related markers (ANP, BNP and β-MHC mRNA) level, reducing cell surface area, and restoring cardiac function. NPY inactivation increased miR-216b and decreased FoxO4 expression in CH heart. Moreover, NPY decreased miR-216b and increased FoxO4 expression in NRVMs which were reversed by NPY type 1 receptor (NPY1R) antagonist BIBO3304. MiR-216b mimic and FoxO4 siRNA (small interfering RNA) inhibited NPY/Ang II-induced myocardial hypertrophy in vitro. Meanwhile, BIBO3304 reversed the pro-hypertrophy effect of NPY in vitro. Collectively, NPY deficiency attenuated CH by NPY1R-miR-216b-FoxO4 axis. These findings suggested that NPY would be a potential therapeutic target for the prevention and treatment of cardiac hypertrophy.
Uncovering the Role of Motor Performance and Creative Thinking on Sports Creativity in Primary School-aged Children

ABSTRACT The demand for creativity in sports has attracted great interest, looking for factors that predict and release children’s creative behavior. Our aim was to determine the effects of motor skills and creative thinking on sports creativity, according to gender and age. 198 children (7.71 ± 1.39 years) were recruited. They completed three motor skills tests, the Torrance Test of Creative Thinking and the Creative Behavior Assessment in Teams Sports. Sprint and change of direction (COD) established to be complementary pairs since predicted all the creative thinking (CT) components. COD emerged as a reliable indicator for attempts and originality in game settings. Abstractness of titles emerged as a key component of CT on sports creativity. According to gender, sprint and COD differently predicted the outcomes; in younger ages both were more effective in predicting CT components. Our findings support an interplay between motor, thinking, and sports creativity, revealing commonalities in the underlying processes responsible for driving CT and novel behaviors in sport. Training programs enforced in motor performance and CT should be included in primary schools’ curricula and in youth sports academies, assisting sports scientists, coaches, and teachers to develop more effective enrichment environments for fostering children’s creative behavior and sports creativity.
Numerical Methods for Viscoelastic Fluid Flows

Complex fluids exist in nature and are continually engineered for specific applications involving the addition of macromolecules to a solvent, among other means. This imparts viscoelasticity to the fluid, a property responsible for various flow instabilities and major modifications to the fluid dynamics. Recent developments in the numerical methods for the simulation of viscoelastic fluid flows, described by continuum-level differential constitutive equations, are surveyed, with a particular emphasis on the finite-volume method. This method is briefly described, and the main benchmark flows currently used in computational rheology to assess the performance of numerical methods are presented. Outstanding issues in numerical methods and novel and challenging applications of viscoelastic fluids, some of which require further developments in numerical methods, are discussed.
Perceived professional competence of clinical research coordinators

Abstract Introduction: This study examined the perceived competence of Clinical Research Coordinators (CRCs) using several conceptual frameworks. Accurate self-assessment of one’s professional competence is a critical component in the career navigation process and contributes to (a) identifying and securing professional development (training), (b) leveraging professional strengths, and (c) integrating self-knowledge into a comprehensive career plan. Method: A survey design gathered responses from a sample of 119 CRCs in a southeastern region of the USA Two conceptual frameworks were used to represent aspects of CRC professional competence: the eight Joint Task Force (JTF) competence domains, and perceptions of strengths and training needs from a list of 12 task categories. Results: The JTF domain with the lowest competence level was Development and Regulations, while the highest was Communication. Perceived competence increased incrementally with years of experience. Top strengths involved direct patient interaction and data management. Tasks in need of training included project management and reporting issues. Variations in responses were based on years of experience as a CRC. Conclusion: Our results demonstrate an association between the self-reported strengths and training needs of CRCs and experience. This information can contribute to the self-directed career navigation of CRCs.
Influence of phosphorus and sulphur on yield and nutrient uptake by summer cluster bean grown on typic ustochrept of Anand

Cluster bean, called guar is a draught-tolerant annual legume belongs to the family Leguminoseae and sub-family Papilonaceae. It has soil enriching properties. Root nodules contain nitrogen fixing bacteria and crop residue when ploughed under, improves the yield of succeeding crops. Cluster bean is a good soil restorative crop which can fix about 40 per cent N in the soil. The primary importance of guar is considered to be the commercial value of its seed gum (galactomannan gum) which is used in sizing textiles and paper as a stickner and in pill formation. Phosphorus stimulates early root development, growth, blomming and aids in seed formation when applied to legumes, it activates rhizobia and formation of root nodules. Thus, it helps in taking more atmospheric N. It also improves the crop quality and resistance to disease. In general S requirement is slightly less than P. It is essential for synthesis of vitamins
Factors Affecting the Meaning in Life of Teachers

This study aims to investigate the various models that affect the meaning in life of teachers. This is a quantitative study with data randomly obtained from a sample of 100 teachers at East Kalimantan, Indonesia. The results showed that self-actualization and self-transcendence are crucial factors which have an impact on the meaning in life of teachers. The policy makers need to utilize the results from this study to design various programs and training for the development of meaning in life of teachers.
Importance of the Primary Motor Cortex in Development of Human Hand/Finger Dexterity

Abstract Hand/finger dexterity is well-developed in humans, and the primary motor cortex (M1) is believed to play a particularly important role in it. Here, we show that efficient recruitment of the contralateral M1 and neuronal inhibition of the ipsilateral M1 identified by simple hand motor and proprioceptive tasks are related to hand/finger dexterity and its ontogenetic development. We recruited healthy, right-handed children (n = 21, aged 8–11 years) and adults (n = 23, aged 20–26 years) and measured their brain activity using functional magnetic resonance imaging during active and passive right-hand extension–flexion tasks. We calculated individual active control-related activity (active–passive) to evaluate efficient brain activity recruitment and individual task-related deactivation (neuronal inhibition) during both tasks. Outside the scanner, participants performed 2 right-hand dexterous motor tasks, and we calculated the hand/finger dexterity index (HDI) based on their individual performance. Participants with a higher HDI exhibited less active control-related activity in the contralateral M1 defined by the active and passive tasks, independent of age. Only children with a higher HDI exhibited greater ipsilateral M1 deactivation identified by these tasks. The results imply that hand/finger dexterity can be predicted by recruitment and inhibition styles of the M1 during simple hand sensory–motor tasks.
Developing Business Risk Resilience through Risk Management Infrastructure: The Moderating Role of Big Data Analytics

ABSTRACT This article evaluates how firms are able to enhance the effectiveness of their Risk Management Infrastructure (RMI) by using Big Data Analytics (BDA) to improve their risk resilience capability. A theoretical model is developed and the corresponding hypothesis is tested through a survey instrument and quantitative analysis. The results show that if firms adopt BDA capabilities then it positively moderates the impact of RMI on risk resilience, improving the effectiveness of a risk management infrastructure.