Miracle-dz/UniFAR-FTUs huggingface dataset:
Hereditary Pancreatic Cancer

Pancreatic cancer is estimated to surpass breast cancer to become the third leading cause of cancer-related death in the USA in 2016. The 5-year overall survival is 7%, and most individuals are diagnosed with advanced disease. Thus, there is a need to improve the early detection of pancreatic cancer in order to detect and improve survival in the same way that mammograms and colonoscopies have improved survival for individuals with breast and colorectal cancer. This chapter discusses the genetics of hereditary pancreatic cancer, the current available screening options, and the use of biomarkers for early detection of pancreatic cancer.
A Case of Primary Ileocecal Lymphoma

Primary lymphoma in gastrointestinal tract is not very common. Ileocecal region is the commonest site for primary lymphoma and diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype. The clinical presentation in this condition is pain in right lower quadrant region and this can very confusing since many diseases can also cause this problem like infection and inflammatory disease. In this paper, we report a case of primary lymphoma subtype DLBCL in ileocecal region that come to emergency department with ileus obstruction. Abdominal computerized tomography (CT) scan and colonoscopy revealed tumour in ileocecal region ascendens colon. Hemicolectomy was performed and the specimen was sent to pathology which revealed non-Hodgkin lymphoma with subtype DLBCL CD20 (+). The patient had undergone of Rituximab, Cyclophosphamide, Doxorubicine, Vincristin, and Prednison (RCHOP) chemotherapy regimen and had complete remission.
Comparative effectiveness of robotic and open radical prostatectomy

Radical prostatectomy (RP) has undergone a remarkable transformation from open to minimally-invasive surgery over the last two decades. However, it is important to recognize there is still conflicting evidence regarding key outcomes. We aimed to summarize current literature on comparative effectiveness of robotic and open RP for key outcomes including oncologic results, health-related quality of life (HRQOL) measures, safety and postoperative complications, and healthcare costs. The bulk of the paper will discuss and interpret limitations of current data. Finally, we will also highlight future directions of both surgical approaches and its potential impact on health care delivery.
Postgraduate trainees’ perceptions of the learning environment in a Nigerian teaching hospital

Background. The learning environment represents various factors that describe the learner’s experiences in that setting. The learning environment of junior doctors undergoing training programmes in hospitals is considered a major factor determining both academic success and health service delivery performance. Increased performance in both areas requires routine assessment of the learning environment to identify components that need attention. Objective. To evaluate the perception of junior doctors undergoing specialist training regarding the learning environment in a teaching hospital. Methods. This was a single-centre, cross-sectional study, using the Postgraduate Hospital Educational Environment Measure (PHEEM). The questionnaire was used to collect data on the learning environment of junior doctors in all 10 clinical departments at the University of Maiduguri Teaching Hospital, Nigeria. All of the junior doctors ( n =148) in the hospital at the time of the study received the questionnaire; they constituted the sample size for the survey. Data collected were analysed to assess junior doctors’ perceptions of the overall learning environment and of the individual factors in the learning environment as measured by the individual items of PHEEM. Results. The hospital educational environment was rated high, with a score of 98.25. The domains of the environment measure also showed positive perceptions, but revealed specific areas in need of attention as measured by the items of the questionnaire. Significant ( p <0.05) differences were noted in the perceptions of some items of the environment in the clinical departments. Conclusions. The junior doctors’ perceptions of their educational environment were positive. The study was able to identify areas of strengths and weaknesses in the overall hospital learning environment and the specialty departments. Overall, it identified the absence of an informative handbook for junior doctors and quality accommodation and catering facilities when the doctors were on call, as well as excess workload and lack of counselling services as areas that require the most attention to improve the learning environment.
Valorisation of pyrolytic tyre char as filler in polypropylene

iii OPSOMMING . v ACKNOWLEDGEMENTS . vii LIST OF FIGURES . xii LIST OF TABLES . xv NOMENCLATURE . xvii CHAPTER 1: INTRODUCTION . 1 1.1. Background . 1 1.1.1 Waste tyre . 1 1.1.2 PP composites . 2 1.2. Problem statement . 2 1.3. Aim . 3 1.4. Significance of research study . 3 1.5. Project scope and limitations . 3 1.6. Thesis overview . 6 CHAPTER 2: LITERATURE REVIEW . 7 2.1. Pyrolysis and demineralisation . 7 2.1.1 Tyre overview . 7 2.1.2 Waste tyre pyrolysis . 8 2.1.3 PT-char physical properties . 9 2.1.4 PT-char composition . 12 2.1.5 Possible applications of PT-char . 17 2.1.6 Demineralisation . 17 2.1. 7 Concluding remarks . 22 Stellenbosch University https://scholar.sun.ac.za
IL-1 inhibitors: What is their right position as therapeutic opportunity?

in 2001 for the treatment of moderate-severe RA in association with methotrexate. However, it is only infrequently used in patients with early and established RA because it is less efficacious than the currently dominant TNF inhibitors and other biological agents [11-13]. ANA has also been found to be effective in many other joint and muscular diseases, and its other currently approved indications are Cryopyrin-Associated Periodic Syndromes (CAPS) and Adult-Onset Still’s Disease (AOSD) [14].
Applying Clinical Guidelines to Curtail Opioid Overprescribing in Primary Care

Applying Clinical Guidelines to Curtail Opioid Overprescribing in Primary Care by Glenda Le Flore BS, Pacific College, 1990 MS, California State University Los Angeles, 1995 FNP-c, University of Southern California, 1996 Project Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Nursing Practice
U-Jacketing Applications of Fiber-Reinforced Polymers in Reinforced Concrete T-Beams against Shear—Tests and Design

The application of externally bonded fiber-reinforced polymer (EB-FRP) as shear transverse reinforcement applied in vulnerable reinforced concrete (RC) beams has been proved to be a promising strengthening technique. However, past studies revealed that the effectiveness of this method depends on how well the reinforcement is bonded to the concrete surface. Thus, although the application of EB-FRP wrapping around the perimeter of rectangular cross-sections leads to outstanding results, U-jacketing in shear-critical T-beams seems to undergo premature debonding failures resulting in significant reductions of the predictable strength. In this work, five shear-critical RC beams with T-shaped cross-section were constructed, strengthened and tested in four-point bending. Epoxy bonded carbon FRP (C-FRP) sheets were applied on the three sides and along the entire length of the shear-strengthened T-beams as external transverse reinforcement. Furthermore, the potential enhancement of the C-FRP sheets anchorage using bolted steel laminates has been examined. Test results indicated that although the C-FRP strengthened beams exhibited increased shear capacity, the brittle failure mode was not prevented due to the debonding of the FRP from the concrete surface. Nevertheless, the applied mechanical anchor of the C-FRP sheets delayed the debonding. Moreover, the design provisions of three different code standards (Greek Code of Interventions, Eurocode 8 and ACI Committee 440) concerning the shear capacity of T-shaped RC beams retrofitted with EB-FRP jackets or strips in U-jacketing configuration are investigated. The ability of these code standards to predict safe design estimations is checked against 165 test data from the current experimental project and data available in the literature.
Mixed methods - theory and practice. Sequential, explanatory approach

There appears to be a paucity of research undertaken in emotional intelligence in higher education suggesting a gap in which research can be undertaken that can provide new insight and add together with knowledge and understanding. This article discusses a study using sequential, explanatory, mixed methodology, which was undertaken on a sample of 533 academics (those employed by a university full time, part time, and hourly and who may be lecturers, tutors, instructors, researchers). The reason for collecting sequential quantitative and qualitative data into one study brings together two types of information providing greater understanding and insight into the research topics that may not have been obtained analysing and evaluating data separately. The findings from interviews helps explain the findings from quantitative data.
Pengaruh Beberapa Dosis Abu Janjang Kelapa Sawit Terhadap Pertumbuhan Bibit Kakao (Theobroma cacao L.)

The plant medium condition in the nursery will affect the growth of cacao seedlings. The oil Palm ash is one of the soil ameliorants because it content complete nutrient both macro and micro, the capability to increasing soil pH and having a high base saturation. The objectives of the research were to study the effect of oil palm ash on the growth of cacao seedlings and to get the dose for cacao in nurseries. This research was conducted in experimenta field of 3rd Campus Andalas University Dharmasraya, in December 2018 until March 2019. The experimental method used was a Completely Randomized Design (CRD) consisted of 5 treatments and 5 replications, each of experiment unit consistent of 2 plant polybag so the total of 50 plants was obtained. The Treatments were some doses of oil palm ash of 0 g of oil palm ash/polybag, 150 g of oil palm ash/polybag, 300 g of oil palm ash/polybag, 450 g of palm oil ash/polybag, and 600 g of oil palm ash/polybag. Data analysis was performed by analysis of variance (F test) at the level of 5%. If its results are significant, then further tests with DNMRT at the level of 5%. The results of the present study showed that oil palm ash had an influence on the growth of cacao seedlings on the variables of stem height, stem diameter, number of leaves, and the root length. The dosage of 450 g oil palm ash/polybag showed the best results for stem height and number of leaves of cacao seedlings, while the dosage of 600 g oil palm ash/polybag showed the best results for stem diameter and root length of cacao seedlings. The recommended dose for cacao in the nursery is 450 g of oil palm ash/polybag.
Enhancing Nitrate Removal from Waters with Low Organic Carbon Concentration Using a Bioelectrochemical System—A Pilot-Scale Study

Assessments of groundwater aquifers made around the world show that in many cases, nitrate concentrations exceed the safe drinking water threshold. This study assessed how bioelectrochemical systems could be used to enhance nitrate removal from waters with low organic carbon concentrations. A two-chamber microbial electrosynthesis cell (MES) was constructed and operated for 45 days with inoculum that was taken from a municipal wastewater treatment plant. A study showed that MES can be used to enhance nitrate removal efficiency from 3.66% day−1 in a control reactor to 8.54% day−1 in the MES reactor, if a cathode is able to act as an electron donor for autotrophic denitrifying bacteria or there is reducing oxygen in a cathodic chamber to favor denitrification. In the MES, greenhouse gas emissions were also lower compared to the control. Nitrous oxide average fluxes were −639.59 and −9.15 µg N m−2 h−1 for the MES and control, respectively, and the average carbon dioxide fluxes were −5.28 and 43.80 mg C m−2 h−1, respectively. The current density correlated significantly with the dissolved oxygen concentration, indicating that it is essential to keep the dissolved oxygen concentration in the cathode chamber as low as possible, not only to suppress oxygen’s inhibiting effect on denitrification but also to achieve better power efficiency.
Purchasing popular purebreds: investigating the influence of breed-type on the pre-purchase motivations and behaviour of dog owners

How and why dog owners select a specific breed may impact upon the health of the dog they acquire, and upon the wider health of the breed they select. Brachycephalic (BC) breeds are rapidly increasing in popularity despite increasing evidence linking brachycephalism with chronic and severe health conditions. This study used a questionnaire to explore pre, during and post-purchase behaviours and attitudes of dog-owners who own popular BC dog breeds (n=3 breeds) compared to popular non-BC dog breeds (n=7 breeds). The survey received 1427 valid responses. BC breed owners were younger, more likely to live with children, and to be buying their chosen breed for the first time. The factor that most highly influenced BC owner’s decisions to buy their breed was appearance, followed by breed size suited to lifestyle, good dog breed for children and good companion breed. Perceived health of the breed was less influential in decision-making for BC owners compared to non-BC owners. The way in which owners acquired their dog differed by breed type, with BC owners more likely to use puppy selling websites to find their dog, less likely to see either parent of their puppy, and less likely to ask to see any health records. Despite many BC breed health issues being directly related to conformation, appearance remains the most significant determinant in why people desire these breeds. More targeted educational interventions are needed to change buyer attitudes and, if ineffective, other more direct mechanisms (e.g. legislation) may be required to protect canine welfare.
One-to-one peer support in mental health

Peer support has been recognised as a valuable resource for individuals with mental health issues; this thesis focuses on one-to-one peer support interventions and naturally occurring peer support. The thesis is presented in three parts. Part I is a literature review of the effectiveness and characteristics of unidirectional peer support interventions for individuals with mental health issues. Fourteen studies met the inclusion criteria. The quality of reporting of the characteristics of the interventions was good. However, the quality of the studies was mixed. The findings of the studies were also mixed, indicating that an empirical base for unidirectional peer support interventions is yet to be established. Part II presents the findings of a qualitative study into service users’ experiences of naturally occurring peer support in inpatient settings. Twelve service users took part in semi-structured interviews. A thematic analysis yielded nine themes organised into two domains. Participants highlighted the importance of peer support, which provided the opportunity to live out valued personal principles and identities. However, there were a number of challenges and barriers to supportive interactions (e.g. the fear of raising a painful topic meant some participants felt the need to tread carefully around others). Further research is needed to explore staff perceptions of mutual peer support on acute inpatient wards, which would guide the implementation of these ideas to inpatient ward policy and procedure. Part III is a critical reflection on the process of carrying out the research reported in Part II. It focuses on the challenges of conducting qualitative research in a mental health setting, the impact of researcher position and a consideration of the results in relation to the wider context of the mental health system.
Positively Resilient? How Framing Local Action Affects Public Opinion

Cities face numerous environmental challenges. Local governments need the public’s support to tackle these problems, and scholars and practitioners have suggested that framing initiatives around resilience, as opposed to sustainability, reducing vulnerability, or adaptation, may increase public support for local action. Resilience, they argue, has a better social connotation, is more positive, and less polarizing than related concepts. Empirical evidence supporting these claims is lacking. In three online survey experiments, we test whether the public is more likely to support policies when they are framed in terms of “resilience. ” We also examine public conceptualizations of these different terms and whether resilience has a more positive connotation. We find significant differences in policy support, perceived importance, and interpretations of the concepts. The study confirms that framing affects policy support, but complicates claims that resilience is inherently more appealing. These findings have implications for urban research and policymaking.
Carbohydrate utilisation by tilapia: a meta‐analytical approach

Currently, studies reporting the digestibility of carbohydrates, starch and especially non-starch polysaccharides (NSP) in fish are scarce. Carbohydrate digestibility in the diet is largely dependent upon carbohydrate composition (starch vs. NSP). NSP are often considered to be indigestible and thus of no nutritional value. The present study reviews carbohydrates in fish feed, distinguishing between total carbohydrate, starch and NSP. Besides a qualitative approach, a meta-analysis was performed, compiling available data from digestibility studies on tilapia. Our meta-analysis confirms the negative effect of NSP on performance (FCR) and nutrient digestibility (crude protein, fat and energy). However, an average NSP digestibility of 24.3% was calculated in 95 cases. Out of these 95 cases, 88% of them showed a positive NSP digestibility. NSP digestibility was shown to contribute to energy digestibility. The digestion of NSP in fish is associated with fermentation in the gut, producing beneficial volatile fatty acids that are rapidly absorbed by the colonic lumen. Therefore, in diet formulation, digestibility and thus energy originating from NSP should be taken into consideration because NSP contribute to the energy needs of fish, here tilapia. Besides being an energy source, specific types of NSP may have immune-modulating and prebiotic effects and may be increasingly added to fish feed as modulators of fish health. We suggest that NSP is potentially (partly) digested by a wide range of fish species, especially by warm-water species with a long gut adapted to feeding on plant matter, as these factors favour gut fermentation.
Crystallite, optical, and photoelectrochemical properties of three-dimensional ZnO/CdS photoelectrodes synthesized by hydrothermal approach

Abstract. A series of ZnO/CdS photoelectrodes with three-dimensional (3-D) structure were synthesized by two-step hydrothermal method. The photoelectrodes were characterized by x-ray diffraction, UV–vis absorption spectrum, and field emission scanning electron microscope. The results confirmed that all samples have similar hierarchical structure composed of CdS sheets and ZnO nanorod. In particular, the sample fabricated by the CdCl2 precursor as the Cd source gave the wider band gap and more porous structure. The photoelectrochemical performance of the samples was estimated by photocurrent density testing in the solution under irradiation. The sample prepared by the CdCl2 precursor exhibited higher photocurrent density than the other three samples due to its 3-D structure, wider band gap, and more porous morphology.
Diuretic Drug Utilization Study

Objective: To evaluate the present use of diuretics in our institution, and determine the appropriateness of that use and the incidence of adverse reactions and interactions. Design: This retrospective study describes the indications for use of an identified drug or combination of drugs. By the time the data were collected, some patients had been discharged or had died. Setting: The study was carried out in a referral center, the University Hospital “Virgen Macarena,” Seville, Spain. Patients: All patients receiving diuretic therapy. Those undergoing hemodialysis or receiving home care were excluded from the study. Intervention: A therapeutic audit was performed using specific standards of reference. Two models were used — one for each of the most frequent indications, ascites and congestive heart failure (CHF). Main Outcome Measures: A structured protocol gathered data on (1) demographic characteristics, (2) causes of admission and pathologic antecedents, (3) diuretic treatment, (4) basic controls (24-h diuresis and daily basal weight), (5) clinical evolution, and (6) concurrent complementary studies. The protocol included a checklist of the most frequent adverse drug reactions and interactions whose degree of causality was determined by applying the modified algorithm of Karch-Lasagna, used in the World Health Organization voluntary reporting system of adverse drug reactions. Results: One hundred twenty-six patients (16% of total admissions) received diuretic therapy. Of these, 71% were analyzed; information in the medical records was incomplete for the rest (29%). Fifty-one percent of the patients were more than 60 years old. The most frequent admission diagnoses were cardiovascular (51.5%), followed by digestive (16.7%) diseases. A total of 134 cardiac symptoms was seen in 50 patients. The most notable were acute pulmonary edema (26%), ischemic cardiopathy (12%), and cardiogenic shock (8%). Most patients receiving diuretic therapy (47.3%) were admitted to the internal medicine service. The most-prescribed diuretic was furosemide (59%), followed by spironolactone (27%). The combined use of furosemide and spironolactone occurred in all but 1 of the patients with hepatic ascites (92%), whereas in those with CHF the figure for the combined use of furosemide and spironolactone fell to 38% (p = 0.001). In 63% of the patients with ascites, the spironolactone dosage was changed in the first 48 hours of treatment. There was a high percentage of deaths (21%) in the study patients. Conclusions: Therapeutic strategy often does not follow the guidelines laid down in the standards of reference on diuretic use in serious CHF and/or ascites in this institution.
Intestinal temperature does not reflect rectal temperature during prolonged, intense running with cold fluid ingestion

It is generally assumed that intestinal temperature (Tint), as measured with a telemetric pill, agrees relatively well with rectal temperature (Trec) during exercise. However, whether Tint reflects Trec during prolonged, intense and continuous exercise when cold fluids are consumed is unknown. Therefore, we compared Trec and Tint during a half-marathon during which cold water was ingested to prevent bodyweight (BW) losses >2%. Nine endurance athletes (age 30 ± 5 years) underwent a 21.1 km running time-trial (TT) in the heat (~30 °C and 44% RH) while BW losses were maintained to ~1% with continuous cold (4 °C) water provision. Tint and Trec were monitored throughout the TT. Hypohydration level, TT time and fluid intake were 1.2 ± 0.4% BW, 93.2 ± 9.9 min and 2143 ± 264 ml, respectively. Trec was systematically higher than Tint by 0.25 °C (95% CI: 0.14–0.37 °C). Tint and Trec showed an excellent relative (r = 0.90, p < 0.01), but poor absolute agreement as reflected by a 95% limit of agreement of ±1.07 °C and a standard error of measurement of ±0.39 °C. In conclusion, Tint does not mirror Trec during prolonged, intense running with cold fluid ingestion and, therefore, these measures should not be used interchangeably under this scenario.