Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating Biomarkers of Fibrosis Formation in Patients with Arrhythmogenic Cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is a progressive inheritable disease which is characterized by a gradual fibro-(fatty) replacement of the myocardium. Visualization of diffuse and patchy fibrosis patterns is challenging using clinically applied cardiac imaging modalities (e.g., late gadolinium enhancement, LGE). During collagen synthesis and breakdown, carboxy–peptides are released into the bloodstream, specifically procollagen type-I carboxy-terminal propeptides (PICP) and collagen type-I carboxy-terminal telopeptides (ICTP). We collected the serum and EDTA blood samples and clinical data of 45 ACM patients (age 50.11 ± 15.53 years, 44% female), divided into 35 diagnosed ACM patients with a 2010 ARVC Task Force Criteria score (TFC) ≥ 4, and 10 preclinical variant carriers with a TFC < 4. PICP levels were measured using an enzyme-linked immune sorbent assay and ICTP levels with a radio immunoassay. Increased PICP/ICTP ratios suggest a higher collagen deposition. We found significantly higher PICP and PICP/ICTP levels in diagnosed patients compared to preclinical variant carriers (p < 0.036 and p < 0.027). A moderate negative correlation existed between right ventricular ejection fractions (RVEF) and the PICP/ICTP ratio (r = −0.46, p = 0.06). In addition, significant correlations with left ventricular function (LVEF r = −0.53, p = 0.03 and end-systolic volume r = 0.63, p = 0.02) were found. These findings indicate impaired contractile performance due to pro-fibrotic remodeling. Follow-up studies including a larger number of patients should be performed to substantiate our findings and the validity of those levels as potential promising biomarkers in ACM.
Ring-shaped discharge structures in a closed cycle MHD disk generator

Numerical simulations are carried out to study plasma properties in a nonequilibrium disk-type MHD generator. The analysis is based on a two-dimensional time-dependent MHD equation, and is performed in the r-z plane. From the r-z analysis, the current distributions in the boundary layer, electrode regions are obtained, as well as the channel main flow region. The two-state nature of plasma, i.e., the formation of streamers and their dynamical behavior in the channel is confirmed. The dependence of the streamer properties on the magnetic field strength and load resistance is examined. The calculations suggest the existence of an eddy current in the boundary layer for the high-loading parameter. Some enhanced eddy currents in the nozzle region and the intensive eddy current at the upper-stream edge of the cathode are obtained for some plasma parameters. 19 references.
Gal-1 Expression Analysis in the GLIOCAT Multicenter Study: Role as a Prognostic Factor and an Immune-Suppressive Biomarker

Glioblastoma (GBM) is the most frequent primary malignant brain tumor and has a dismal prognosis. Unfortunately, despite the recent revolution of immune checkpoint inhibitors in many solid tumors, these have not shown a benefit in overall survival in GBM patients. Therefore, new potential treatment targets as well as diagnostic, prognostic, and/or predictive biomarkers are needed to improve outcomes in this population. The β-galactoside binding protein Galectin-1 (Gal-1) is a protein with a wide range of pro-tumor functions such as proliferation, invasion, angiogenesis, and immune suppression. Here, we evaluated Gal-1 expression by immunohistochemistry in a homogenously treated cohort of GBM (the GLIOCAT project) and correlated its expression with clinical and molecular data. We observed that Gal-1 is a negative prognostic factor in GBM. Interestingly, we observed higher levels of Gal-1 expression in the mesenchymal/classical subtypes compared to the less aggressive proneural subtype. We also observed a Gal-1 expression correlation with immune suppressive signatures of CD4 T-cells and macrophages, as well as with several GBM established biomarkers, including SHC1, PD-L1, PAX2, MEOX2, YKL-40, TCIRG1, YWHAG, OLIG2, SOX2, Ki-67, and SOX11. Moreover, Gal-1 levels were significantly lower in grade 4 IDH-1 mutant astrocytomas, which have a better prognosis. Our results confirm the role of Gal-1 as a prognostic factor and also suggest its value as an immune-suppressive biomarker in GBM.
System of Work and Stress-Coping Strategies Used by Nurses of a Polish Hospital during the COVID-19 Pandemic

The COVID-19 pandemic contributed to increased stress levels experienced by employees of the healthcare system during their professional activities. The aim of the study was to compare the stress-coping strategies used by nurses in two different systems of work (one shift/two shifts) in a Polish hospital in 2021. The study used the Polish adaptation of the Mini-COPE questionnaire and the authors’ data sheet. The results indicate that regardless of experience or the place and system of work, nurses more often chose problem-focused coping strategies. Conducting screening tests among nurses will help to establish effective strategies for coping with occupational stress, thus preventing professional burnout.
A Rare Case of Suspected Neuronal Intranuclear Inclusion Disease Requiring Differentiation From Neuro-Behçet’s Disease

A 69-year-old male patient with a long-standing history of Behçet’s disease was admitted to another hospital with minor physical injuries after a traffic accident. However, the patient was subsequently transferred to our facility because of a prolonged disorder of consciousness suspected to be related to neuro-Behçet’s disease (NBD). A thorough patient evaluation for determining the most appropriate treatment course led to a strong suspicion of neuronal intranuclear inclusion disease and predominantly ruled out NBD. This eliminated the need for unnecessary immunosuppressive intervention. Thereafter, the patient was transferred to a long-term care facility. This case highlights the importance of careful identification of pathological conditions before developing a treatment plan, regardless of the presence or absence of an underlying disease.
Laparoscopic Sleeve Gastrectomy versus Laparoscopic Roux-en-Y Gastric Bypass: An Analysis of Weight Loss Using a Multilevel Mixed-Effects Linear Model

Background: Regarding weight loss outcomes, the results published after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y (LRYGB) are conflicting. At this time, no clear evidence exists that outcomes from LSG are similar to those for LRYGB. The main objective of this study was to compare the percent of total weight loss (%TWL) between LRYGB and LSG over the first 2 years using a multilevel mixed-effects linear regression. Methods: Data were collected from a prospectively maintained database of patients who underwent primary laparoscopic bariatric surgery from January 2016 to December 2017 at a French accredited bariatric center. The medical records of 435 consecutive patients were analyzed. %TWL was calculated at each follow-up surgical consultation and used as a repeated outcome variable in our models to assess the long-term %TWL. Due to this hierarchical structure of the data (%TWL at each visit = level 1) within patients (level 2), a multilevel linear regression adjusted for age, sex, preoperative BMI and comorbidities was used. Results: Among the medical records of 435 consecutive patients included, 266 patients underwent LRYGB and 169 underwent LSG. The average %TWL at 2 years was 31.7% for the LRYGB group and 25.8% for the LSG group. The final multivariate model showed that, compared with LRYGB, LSG was associated with a decreased %TWL at over 2 years of follow-up (β: −4.01; CI95%: −5.47 à −2.54; p ≤ 0.001). Conclusion: This observational study suggests that compared with LRYGB, LSG was associated with a decreased %TWL at 2 years using a multilevel model. Further studies are required to confirm the results observed with this statistical model.
Steam-Jet Evaluation for Predicting Leakage Behavior and Interpretation of Experimental Verification

Owing to pipe thinning, fatigue damage, and aging, pipes, valves, and devices installed in the primary and secondary systems of nuclear power plants may leak high-temperature/high-pressure reactor coolant. Thus, a system must be developed to determine if the leakage is exceeding the operating limit of the nuclear power plant, thereby mitigating any loss of life or economic loss in such cases. In this study, a validated numerical analysis method was established to initially simulate the leakage behavior and subsequently to evaluate the small amount of leakage in the compartment. For this purpose, a vapor-jet collision test in the compartment and a vapor-jet test in the pipe were performed; numerical analysis was conducted, and comparative analysis was performed to verify the validity of the established method. The evaluation results suggested that the proposed numerical analysis method could optimally simulate the flow characteristics of the steam jet. Notably, compared to the existing evaluation method, the proposed approach simulated a more detailed behavior of the jet formed at the leakage point. In future research, the results of this study (data) will be used to inform the design of the second phase of the leak-capture system and will be served as the foundation for a performance-optimization study on the capture system.
An Online Questionnaire-Based Survey of 1076 Individuals in Poland to Identify the Prevalence of Ophthalmic Symptoms in Autumn 2022

Background Vision health affects functioning in society, and the ability to learn and work. Ophthalmic symptoms may be caused by eye diseases, but also by environmental or lifestyle factors. This online questionnaire-based survey aimed to identify the prevalence of ophthalmic symptoms in 1076 individuals in Poland, as well as to identify factors associated with the presence of ophthalmic symptoms. Material/Methods An online questionnaire-based survey was carried out in December 2022 on a representative sample of 1076 adult Poles. Non-probability quota sampling was used. Respondents were asked about the presence of 16 different eye symptoms and vision problems in the last 30 days. The presence of ophthalmic symptoms was self-declared. Data were analyzed with IBM SPSS package version 28. Results More than half of the respondents (57.8%) had at least 1 ophthalmic symptom in the last 30 days. Burning and stinging eyes (21.6%) and dry eyes (18.9%) were the most common ophthalmic symptoms declared by the respondents. Moreover, 21.3% of respondents reported vision deterioration in the last 30 days. Out of 10 different factors analyzed in this study, female gender, living in rural areas or small cities (below 100 000 inhabitants), living with at least 1 other person, having low economic status, having chronic diseases, and wearing spectacles/contact lenses were significantly associated (P<0.05) with the presence of ophthalmic symptoms in the last 30 days. Conclusions This study revealed a high prevalence of ophthalmic symptoms among adults in Poland in autumn 2022. Public health interventions are needed to improve eye health.
‘From the cat’s point of view’: upper secondary physics students’ reflections on Schrödinger’s thought experiment

The thought experiment ‘Schrödinger’s cat’ exposes fundamental dilemmas in how we interpret quantum physics, and has a potential for deepening students’ understanding of this part of modern physics, including its philosophical consequences. In this paper we report results from the project ReleQuant on how Norwegian physics students in upper secondary schools interpret the thought experiment. The analysis resulted in nine categories, and we discuss how these relate to interpretations made by physicists, in particular the concept of superposition. Even if students’ responses in many cases can be related to interpretations that make sense in physics, we conclude that lack of knowledge about the purpose and the historical context of the thought experiment limits students understanding of the physics content. Exploring the thought experiment from a historical perspective might deepen student understanding of key concepts in quantum physics as well as of how physics develops.
Elexacaftor-Tezacaftor-Ivacaftor: A Life-Changing Triple Combination of CFTR Modulator Drugs for Cystic Fibrosis

Cystic fibrosis (CF) is a potentially fatal monogenic disease that causes a progressive multisystemic pathology. Over the last decade, the introduction of CF transmembrane conductance regulator (CFTR) modulator drugs into clinical practice has profoundly modified the lives of many people with CF (PwCF) by targeting the fundamental cause of the disease. These drugs consist of the potentiator ivacaftor (VX-770) and the correctors lumacaftor (VX-809), tezacaftor (VX-661), and elexacaftor (VX-445). In particular, the triple combination of CFTR modulators composed of elexacaftor, tezacaftor, and ivacaftor (ETI) represents a life-changing therapy for the majority of PwCF worldwide. A growing number of clinical studies have demonstrated the safety and efficacy of ETI therapy in both short- and long-term (up to two years of follow-up to date) and its ability to significantly reduce pulmonary and gastrointestinal manifestations, sweat chloride concentration, exocrine pancreatic dysfunction, and infertility/subfertility, among other disease signs and symptoms. Nevertheless, ETI therapy-related adverse effects have also been reported, and close monitoring by a multidisciplinary healthcare team remains vital. This review aims to address and discuss the major therapeutic benefits and adverse effects reported by the clinical use of ETI therapy for PwCF.
Self-consistent hybrid simulations of the interaction of the heliosphere with the local interstellar medium

A new method for investigating the interaction of the solar wind with the partially ionized local interstellar medium (LISM) is presented. The solar wind and the interstellar plasma are modeled using a two-dimensional (2-D) hydrodynamic numerical code. The plasma is coupled to the neutral hydrogen (of both interstellar and solar wind origin) via resonant charge exchange. To model the neutral H distribution, we use a nonstationary 2.5-D particle mesh, method to solve the Boltzmann equation, which is coupled self-consistently to the interstellar and solar wind plasma. Numerical self-consistency is achieved by iterating the plasma and neutral H distributions between the two numerical schemes until a steady state is achieved. Results from three test applications are presented and discussed, including the first one-shock kinetic simulation. The simulations are able to reproduce the main features of the heliosphere such as shock structure, hydrogen wall, and heating, deceleration and filtration of neutral hydrogen. In addition, they enable the study and interpretation of the non-Maxwellian hydrogen distribution function. Traces of fast neutrals originating inside the termination shock and the heliosheath/heliotail region can be found far upstream of the outer heliosphere. The influence of different interstellar plasma boundary values on the heliosphere is highlighted in the comparison of two supersonic simulations and one subsonic simulation. In particular, by comparing the simulated energetic neutral atom (ENA) fluxes at 1 AU of the supersonic and subsonic models, it is found that the subsonic flux is significantly underabundant in the energy range 10 – 60 eV compared to the supersonic case. This may offer an important diagnostic for determining whether the heliosphere possesses a bow shock or not.
Incoherent scattering of radar waves in the auroral ionosphere

We have systematically studied the effects that non-Maxwellian ion velocity distributions produce on the ionic part of the spectrum of radar waves incoherently scattered from the disturbed high-latitude ionosphere in the upper E and lower F regions. For ion to electron temperature ratios smaller than or equal to unity and electric field strengths greater than about 70 mV/m the spectrum is seriously distorted from the shape that it would normally have if the ion velocity distribution were Maxwellian. In events where the magnetospheric convection electric field exceeds 70 mV/m the interpretation of the data is affected if the erroneous assumption of a Maxwellian distribution is used to analyze the data. The electron temperature is the property most seriously affected by the erroneous interpretation, as it can be underestimated by as much as a factor of 2. Finally, the spectra obtained under disturbed conditions are anisotropic, the least distortions from a Maxwellian-type spectrum being found along the magnetic field direction. The apparent ion temperature seen along the line of sight of the radar as it scans from parallel to the magnetic field to nearly perpendicular to the magnetic field also increases as the angle with the magnetic field increases, even for dc electric field strengths as small as 20 mV/m.
Q -state Potts model by Wilson's exact renormalization-group equation

Pour d=4-e, des lignes de points fixes critiques et tricritiques sont calculees en fonction du nombre d'etats du modele de Potts, et elles s'annihilent pour une valeur critique de ce nombre d'etats. Au-dela de ce nombre critique, la transition de Potts est du premier ordre. Le long de ces lignes de points fixes, on calcule les exposants critiques et tricritiques en fonction de e et de δ=Q-2. On etudie aussi le cas limite de la percolation pour 3≤d≤6
Simplified theory of the near-wall turbulent layer of Newtonian and drag-reducing fluids

We propose a simplified theory of a viscous layer in near-wall turbulent flow that determines the mean-velocity profile and integral characteristics of velocity fluctuations. The theory is based on the concepts resulting from the experimental data implying a relatively simple almost-ordered structure of fluctuations in close proximity to the wall. On the basis of data on the greatest contribution to transfer processes made by the part of the spectrum associated with the main size of the observed structures, the turbulent fluctuations are simulated by a three-dimensional running wave whose parameters are found from the problem solution. Mathematically the problem reduces to the solution of linearized Navier-Stokes equations. The no-slip condition is satisfied on the wall, whereas on the outer boundary of a viscous layer the conditions of smooth conjunction with the asymptotic shape of velocity and fluctuation-energy profiles resulting from the dimensional analysis are satisfied. The formulation of the problem is completed by the requirement of maximum curvature of the mean-velocity profile on the outer boundary applied from stability considerations. The solution of the problem does not require any quantitative empirical data, although the conditions of conjunction were formulated according to the well-known concepts obtained experimentally. As a result, the near-wall law for the averaged velocity has been calculated theoretically and is in good agreement with experiment, and the characteristic scales for fluctuations have also been determined. The developed theory is applied to turbulent-flow calculations in Maxwell and Oldroyd media. The elastic properties of fluids are shown to lead to near-wall region reconstruction and its associated drag reduction, as is the case in turbulent flows of dilute polymer solutions. This theory accounts for several features typical of the Toms effect, such as the threshold character of the effect and the decrease in the normal fluctuating velocity. The analysis of the near-wall Oldroyd fluid flow permits us to elucidate several new aspects of the drag-reduction effect. It has been established that the Toms effect does not always result in thickening of the viscous sublayer; on the contrary, the most intense drag reduction takes place without thickening in the viscous sublayer.
A Preconditioning Matrix for the Chebyshev Differencing Operator

An efficient preconditioner for the Chebyshev differencing operator is considered. The corresponding preconditioned eigenvalues are real and positive and lie between 1 and ${\pi / 2}$. An eixpelicit formula for these eigenvalues and the corresponding eigenfunctions is given. The results are generalized to the case of operators related to Chebyshev discretizations of systems of linear differential equations.
The Role of ERα and ERβ in Castration-Resistant Prostate Cancer and Current Therapeutic Approaches

Castration-resistant prostate cancer, or CRPC, is an aggressive stage of prostate cancer (PCa) in which PCa cells invade nearby or other parts of the body. When a patient with PCa goes through androgen deprivation therapy (ADT) and the cancer comes back or worsens, this is called CRPC. Instead of androgen-dependent signalling, recent studies show the involvement of the estrogen pathway through the regulation of estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in CRPC development. Reduced levels of testosterone due to ADT lead to low ERβ functionality in inhibiting the proliferation of PCa cells. Additionally, ERα, which possesses androgen independence, continues to promote the proliferation of PCa cells. The functions of ERα and ERβ in controlling PCa progression have been studied, but further research is needed to elucidate their roles in promoting CRPC. Finding new ways to treat the disease and stop it from becoming worse will require a clear understanding of the molecular processes that can lead to CRPC. The current review summarizes the underlying processes involving ERα and ERβ in developing CRPC, including castration-resistant mechanisms after ADT and available medication modification in mitigating CRPC progression, with the goal of directing future research and treatment.
Self-Locking Polymeric Clips Are Safe for the Closure of Appendiceal Stump in Laparoscopic Appendectomy

Background: Closure of the appendix stump is critical to avoid serious postoperative complications. There are a number of options, but the best one has not been identified yet. The purpose of this study is to evaluate the outcomes of appendiceal stump closure using self-locking polymeric clips and endoloops. Methods: A retrospective analysis of the prospectively maintained database of patients with acute appendicitis was performed. Patient demographic details and surgical characteristics, including the duration of hospital stay, postoperative complications, and also the cost of the appendix stump closure, were recorded. Patients were divided into two groups according to the appendix stump closure method: the clips group if it was closed with self-locking polymeric clips and the loops group if Vicryl or PDS loops were used. Statistical analysis was performed using Pearson’s chi-squared test, Wilcoxon rank sum (Mann–Whitney U) test, and Fisher’s exact test in R statistical software package version 4.2. 1. Results: 515 patients were included in the study from June 2016 to April 2021. There were no significant differences in terms of demographics (p-value in comparison of groups’ sex > 0.99, age p-value 0.16), postoperative complications (p-value > 0.99), histological findings (p-value 0.27), or length of hospital stays (p-value 0.18) between the two patient groups (clips group, N = 454 and loops group, N = 61). The price of operation while using different appendiceal stump closures is significantly different. In a laparoscopic appendectomy, one stump closure with self-locking clips costs 7.69 €, with Vicryl loops—91.35 €, with PDS loops—96.51 €, and with a stapler—514.50 €. Conclusions: Self-locking polymeric clips can be used for the safe and effective closure of an appendiceal stump. There were no significant differences in the postoperative time (30 days) or complication rates among patients in both (clips and loops) groups. Thus, this might be a technique to reduce expenses while maintaining good postoperative results after laparoscopic appendectomy.