Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in Soil Chemical Properties Due to Long-Term Compost Fertilization Regulate Methane Turnover Related Gene Abundances in Rice Paddy

Maintaining rice yield, soil function, and fertility are essential components of long-term compost fertilization. However, paddy fields are major sources of anthropogenic methane emissions. The aim of the study is to evaluate the changes in soil chemical properties and their concurrent impact on the abundance of methanogenesis (mcrA) and methane oxidation (pmoA) related genes among compost (Com), NPK+Compost (NPKCom), and unfertilized (NF) fallow paddy fields under long-term compost fertilization. Results showed that compost and NPK+Compost fertilization altered the soil chemical properties of paddy fields with a significant increase in the functional gene abundance potentially associated with Methanobacteriaceae for mcrA (1.23 × 106 to 3.84 × 106 copy number g−1 dry soil) and methane oxidizing bacteria such as Methylomonas and Methylobacter for pmoA (1.65 × 106 to 4.3 × 106 copy number g−1 dry soil). Ordination plots visualized these changes, where treatments clustered distinctly indicating that Com and NPKCom treatments were characterized by paddy soils with elevated OM, TN, K and P content and higher abundances of methanogenesis and methane oxidation related genes. The study showed that long-term compost fertilization resulted in paddy fields with high nutrient content and high gene abundance, attributed to methanogens and methane oxidizing bacteria that responded well with compost fertilization. These results indicated the potential of these fallow paddy fields for methane emission and methane oxidation and that they are ‘primed’, potentially influencing subsequent paddy field responses to long-term compost application.
Hybridizing of Whale and Moth-Flame Optimization Algorithms to Solve Diverse Scales of Optimal Power Flow Problem

The optimal power flow (OPF) is a practical problem in a power system with complex characteristics such as a large number of control parameters and also multi-modal and non-convex objective functions with inequality and nonlinear constraints. Thus, tackling the OPF problem is becoming a major priority for power engineers and researchers. Many metaheuristic algorithms with different search strategies have been developed to solve the OPF problem. Although, the majority of them suffer from stagnation, premature convergence, and local optima trapping during the optimization process, which results in producing low solution qualities, especially for real-world problems. This study is devoted to proposing an effective hybridizing of whale optimization algorithm (WOA) and a modified moth-flame optimization algorithm (MFO) named WMFO to solve the OPF problem. In the proposed WMFO, the WOA and the modified MFO cooperate to effectively discover the promising areas and provide high-quality solutions. A randomized boundary handling is used to return the solutions that have violated the permissible boundaries of search space. Moreover, a greedy selection operator is defined to assess the acceptance criteria of new solutions. Ultimately, the performance of the WMFO is scrutinized on single and multi-objective cases of different OPF problems including standard IEEE 14-bus, IEEE 30-bus, IEEE 39-bus, IEEE 57-bus, and IEEE118-bus test systems. The obtained results corroborate that the proposed algorithm outperforms the contender algorithms for solving the OPF problem.
Low-temperature processed beta-phase In2Se3 ferroelectric semiconductor thin film transistors

As scaling becomes increasingly difficult, there is growing interest in vertical or three-dimensional stacking of transistors and especially memory. Ferroelectric semiconductor field effect transistors can be key enablers to improve energy efficiency and overall chip and memory performance. In this work, low-temperature processed, back-end-of-the-line compatible transistors were demonstrated by depositing a layered chalcogenide ferroelectric semiconductor, beta-phase In2Se3, at temperature as low as 400 °C. Top gate n-channel In2Se3 thin film transistors were fabricated with field-effect mobility ∼1 cm2 V−1 s−1, and simple polarization switching based memory results are presented.
Myco-Synthesized Molluscicidal and Larvicidal Selenium Nanoparticles: A New Strategy to Control Biomphalaria alexandrina Snails and Larvae of Schistosoma mansoni with an In Silico Study on Induced Oxidative Stress

Schistosomiasis is a tropical disease with socioeconomic problems. The goal of this study was to determine the influence of myco-synthesized nano-selenium (SeNPs) as a molluscicide on Biomphlaria alexandrina snails, with the goal of reducing disease spread via non-toxic routes. In this study, Penicillium chrysogenum culture filtrate metabolites were used as a reductant for selenium ions to form nano-selenium. The SeNPs were characterized via UV-Vis spectrophotometer, Fourier transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray diffraction (XRD). Myco-synthesized SeNPs had a significant molluscicidal effect on B. alexandrina snails after 96 h of exposure at a concentration of 5.96 mg/L. SeNPs also had miracidicidal and cercaricidal properties against S. mansoni. Some alterations were observed in the hemocytes of snails exposed to SeNPs, including the formation of pseudopodia and an increasing number of granules. Furthermore, lipid peroxide, nitric oxide (NO), malondialdehyde (MDA), and glutathione s-transferase (GST) increased significantly in a dose-dependent manner, while superoxide dismutase (SOD) decreased. The comet assay revealed that myco-synthesized SeNPs could cause breaks in the DNA levels. In silico study revealed that SeNPs had promising antioxidant properties. In conclusion, myco-synthesized SeNPs have the potential to be used as molluscicides and larvicides.
How Serious Are Health-Related Welfare Problems in Unowned Unsocialised Domestic Cats? A Study from Denmark Based on 598 Necropsies

Simple Summary Domestic cats are very popular companion animals, but a significant number are ownerless. These are either socialised or unsocialised. The former can be re-homed. Unsocialised domestic cats, on the other hand, are difficult to handle and fear humans. Therefore, rehoming them is challenging. Unowned unsocialised cats are seen by many people as a nuisance, a hazard to human and animal health, and a threat to biodiversity. However, others have concerns about their welfare, although our knowledge of how well these cats actually cope is very limited. To remedy this, we studied the corpses of 598 unsocialised cats euthanised in Denmark in 2019 by two cat welfare organisations. Our findings reveal that unsocialised cats in Denmark face only a moderate load of health-related welfare problems, even in comparison with owned cats. So, although there may be other reasons to euthanise unsocialised cats, this practice may, in a place like Denmark, be difficult to justify by pointing to the welfare needs of the cats. Abstract Free ranging unsocialised domestic cats are widely believed to suffer from a high load of welfare problems. We assessed the validity of this belief by performing necropsies on the corpses of 598 unsocialised cats, originating from all parts of Denmark, that had been euthanised by two Danish cat welfare organisations. We selected a number of variables for health-related cat welfare that could be assessed through necropsy (e.g., gross lesions, ectoparasites and body condition) or by laboratory analysis (e.g., infection with feline immunodeficiency virus (FIV), and by feline leukaemia virus (FeLV)). Each finding was classified as having either a major or minor welfare impact on the cat. More than 83% of the cats had no major finding, and 54% had no finding indicating a welfare issue at all. More than 83% of the cats had a body condition within normal range. Only 0.3% were emaciated. The most common finding was infestation with ectoparasites, with 15.9% infected with lice, 12.3% with fleas, 4.7% with ticks, and 6.7% with ear mites. FIV and FeLV were detected in 9.2% and 1.2% of the cases, respectively. The most common lesion related to the cats’ teeth. Overall, unsocialised cats in Denmark have a moderate level of health-related welfare problems.
Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance

Simple Summary KRAS is the most frequently mutated oncogene in non-small cell lung cancers (NSCLC), with a frequency around 30%, and among them KRAS G12C mutation occurs in 11% of cases. KRAS mutations were for a long time considered to be non-targetable alterations or “undruggable”. Direct inhibition is actually developped with switch-II mutant selective covalent KRAS G12C inhibitors with small molecules such as sotorasib or adagrasib preventing conversion of the mutant protein to GTP-bound active state. Little is known about primary or acquired resistance. Acquired resistance does occur and could be related to genetic alterations in the nucleotide exchange function or adaptive mechanisms either in down-stream pathways or in newly expressed KRAS G12C mutation. Mechanisms of resistance could be classified as “on-target” mechanisms, involving KRAS G12C alterations, or “off-target” mechanisms, involving other gene alterations and/or phenotypic changes. Abstract KRAS is the most frequently mutated oncogene in non-small cell lung cancers (NSCLC), with a frequency of around 30%, and encoding a GTPAse that cycles between active form (GTP-bound) to inactive form (GDP-bound). The KRAS mutations favor the active form with inhibition of GTPAse activity. KRAS mutations are often with poor response of EGFR targeted therapies. KRAS mutations are good predictive factor for immunotherapy. The lack of success with direct targeting of KRAS proteins, downstream inhibition of KRAS effector pathways, and other strategies contributed to a focus on developing mutation-specific KRAS inhibitors. KRAS p.G12C mutation is one of the most frequent KRAS mutation in NSCLC, especially in current and former smokers (over 40%), which occurs among approximately 12–14% of NSCLC tumors. The mutated cysteine resides next to a pocket (P2) of the switch II region, and P2 is present only in the inactive GDP-bound KRAS. Small molecules such as sotorasib are now the first targeted drugs for KRAS G12C mutation, preventing conversion of the mutant protein to GTP-bound active state. Little is known about primary or acquired resistance. Acquired resistance does occur and may be due to genetic alterations in the nucleotide exchange function or adaptative mechanisms in either downstream pathways or in newly expressed KRAS G12C mutation.
Impact of cultural heritage rejuvenation experience quality on perceived value, destination affective attachment, and revisiting intention: evidence from China

ABSTRACT Based on responses from 504 tourists from four well-known cultural heritage destinations in Chongqing, China, structural equation modelling is conducted examine the relationship among cultural heritage rejuvenation experience quality, perceived value, destination affective attachment, and revisiting intention. Results indicated that perceived value positively correlated with destination affective attachment and revisiting intention; museum rejuvenation experience quality, former site rejuvenation experience quality, and cultural products rejuvenation experience quality variables positively correlated with perceived value; former site rejuvenation experience quality and cultural products rejuvenation experience quality positively correlated with destination affective attachment and revisiting intention.
Numerical Simulations of the Cabbeling Phenomenon in Surface Gravity Currents in Cold Fresh Water

The behaviour of warm water discharge at a temperature higher then Tm horizontally into a homogeneous body of cold fresh water at a temperature lower then Tm was investigated by means of a numerical model. Water density here was taken to be a quadratic function of temperature. Thus cabbeling process was inevitable as positively buoyant water form surface current while penetrating the ambient water. The current halted as mixture became dense and sink. These results are very similar to the experimental study of warm discharge into cold water by Marmoush et al. [14] and Bukreev [22]. The results showed an initially sinking water at the point where the two water bodies meets within the first few time interval. Development of Rayleigh-Taylor instabilities was observed at the lower part of the surface current as lighter fluid penetrate further. The frontal head was found to being replenished by a surface flow of warm unadulterated water, but after much entrainment of ambient fluid and cabbeling then, this head halted and sink. On the floor, denser fluid advance in the same direction as the original surface current, with some degree of Kelvin-Helmholtz instability as it penetrates further. Relations were also drawn that describes the speed, the spread length of both surface current were obtained. Relation were also drawn that describes the final spread length of the surface current Lsm and the time taken to reach that final spread length Tsm as a function ϕin. This work as presented here is practical and relevant to many fields of study and also enhances policy making towards the protection of the aquatic ecosystems.
Equids’ Core Vaccines Guidelines in North America: Considerations and Prospective

Vaccination against infectious diseases is a cornerstone of veterinary medicine in the prevention of disease transmission, illness severity, and often death in animals. In North American equine medicine, equine vaccines protecting against tetanus, rabies, Eastern and Western equine encephalomyelitis, and West Nile are core vaccines as these have been classified as having a heightened risk of mortality, infectiousness, and endemic status. Some guidelines differ from the label of vaccines, to improve the protection of patients or to decrease the unnecessary administration to reduce potential side effects. In North America, resources for the equine practitioners are available on the American Association of Equine Practitioners (AAEP) website. Conversely, in small companion animals, peer review materials are regularly published in open access journals to guide the vaccination of dogs and cats. The aims of this review are to present how the vaccine guidelines have been established for small companion animals and horses in North America, to review the equine literature to solidify or contrast the current AAEP guidelines of core vaccines, and to suggest future research directions in the equine vaccine field considering small companion animal strategies and the current available resources in equine literature.
Developing Item Analysis of Teacher–Made Test for Summative Assessment of Seventh Grade of SMPN 8 Komodo in Academic Year 2020/2021

It was the goal of this study to improve the analysis of teacher-made English test items and to evaluate their quality. The researchers used the Research & Development (R&D) procedure to adapt the ADDIE model. @Aloytemsis, the development's product, became the answer as a result of a needs assessment. At SMPN 8 Komodo, the validity, reliability, index difficulty, and discriminating power of the summative test items were all graded. 43 students who had to take the summative test participated in the field testing. In case of validity, it indicated that 15 items (37.5%) were classified into ‘invalid’ due to the validity index were < 0.279. Meanwhile, 25 items (62.5%) were classified into ‘valid’ criteria regarding the value of validity index were > 0.279. Then, the items under consideration received a reliability index of 0.762. In other words, the “teacher-made English summative test items” were deemed “Good Reliable”. It was discovered that the tough category contained 22 items (55%), the medium category contained 18 items (45%), and the easy category contained just 0 items (0%). Lastly, it is found that the items test were 13 items (32.5%) were in the category ‘Poor’ items due to its value of discrimination index 0.00-0.19. Then, in the category ‘Enough’, there were 12 items (30%). On the other hand, there were 15 items (37.5%) were classified into ‘Good’ items. Unfortunately, there was no items into category ‘Very Good’ items.
Disorder-Specific Profiles of Self-Perceived Emotional Abilities in Schizophrenia and Major Depressive Disorder

Deficits in social cognition are a core feature of neuropsychiatric disorders. The purpose of this study was to compare profiles of self-perceived abilities across the core domains of emotional functioning between patients with schizophrenia (n = 22), major depressive disorder (n = 31) and healthy participants (n = 43) with the Self-report Emotional Ability Scale (SEAS). Profile analyses were used to explore group differences in the overall level of self-perceived effectiveness of emotional functioning and in the patterns in which the four functions of emotion perception and regulation in the intra- and inter-personal domains are arranged to each other. Both patient groups showed significantly lower overall levels of self-perceived emotional functioning compared to healthy controls. Most importantly, we found significant differences between patient groups in their profile patterns. Patients with schizophrenia indicated experiencing difficulties in all investigated domains, but the profile pattern largely matched that of healthy individuals. Instead, the profile of patients with depression was much more accentuated, showing lower perceived effectiveness of emotion perception and regulation in the intra-personal domain compared to inter-personal functions. Our results of disorder-specific emotional deficits may have profound implications for early screening and identification of at-risk populations as well as recovery-oriented interventions.
Sodium Glucose Cotransporter-2 Inhibitors: Spotlight on Favorable Effects on Clinical Outcomes beyond Diabetes

Sodium glucose transporter type 2 (SGLT2) molecules are found in proximal tubules of the kidney, and perhaps in the brain or intestine, but rarely in any other tissue. However, their inhibitors, intended to improve diabetes compensation, have many more beneficial effects. They improve kidney and cardiovascular outcomes and decrease mortality. These benefits are not limited to diabetics but were also found in non-diabetic individuals. The pathophysiological pathways underlying the treatment success have been investigated in both clinical and experimental studies. There have been numerous excellent reviews, but these were mostly restricted to limited aspects of the knowledge. The aim of this review is to summarize the known experimental and clinical evidence of SGLT2 inhibitors’ effects on individual organs (kidney, heart, liver, etc.), as well as the systemic changes that lead to an improvement in clinical outcomes.
Clinical Spectrum of Alcoholic Liver Disease in Subjects Attending Outpatient Department at a Tertiary Care Hospital

Background: Alcoholic liver disease is one of the primary medical complication of chronic ethanol abuse. It encloses a wide spectrum of diseases comprising of fatty liver, alcoholic hepatitis, alcoholic cirrhosis and hepatocellular carcinoma. Methodology: A prospective, observational study was done at AIG hospitals in the department of hepatology for a period of 6 months. A total of 200 patient’s diagnosed clinically and biochemically with various spectrum of ALD were recruited for the study.Non-invasive prognostic scores were calculated at the time of admission and correlated with severity of disease. Results: Among 200 study participants, 34.8% belongs to age group of 36-45 years. All were male patients with age group ranged from 25 to 73 years. We observed the high levels of alkaline phosphatese, aspartate aminotransferase/alanine aminotransferase ratio, mean corpuscular volume, total bilirubin and international normalized ratio in Severe Alcoholic hepatitis patients. Non-invasive prognostic markers like child-turcotte-pugh score,model for end stage liver disease-sodium and maddrey’s discriminant factor were assessed for all patients.Prevalence of different stages of ethanol mediated liver disease were-12% of alcoholic fatty liver,17.5% of alcoholic hepatitis,6% of acute on chronic liver failure,32.5% of chronic liver disease,24% of decompensated chronic liver disease,6% of past decompensated chronic liver disease with current living donor liver transplant and 2% cases of hepatocellular carcinoma. Conclusion: Hazardous ethanol abuse is more typical in adult males especially among productive age group. The subjects were cautioned on their personal basis regarding fallout of alcoholic liver disease, and guided for latency of alcohol not immediately but definitely.
The Impact of Real-World Alternative Dosing Strategies of Palbociclib on Progression-Free Survival in Patients with Metastatic Breast Cancer

Background: Palbociclib, a cyclin-dependent kinase 4 and 6 (CDK 4/6) inhibitor, in combination with letrozole or fulvestrant has been demonstrated to prolong the progression-free survival (PFS) in patients with hormone receptor-positive (HR+), human epidermal growth factor 2-negative (HER2-) metastatic breast cancer. In efforts to mitigate neutropenic toxicities, oncologists in real-world practice have prescribed alternative dosing strategies with palbociclib, yet the implication on PFS is unknown. Methods: We conducted a retrospective, observational chart review of all female patients at our clinics with HR+, HER2- metastatic breast cancer receiving palbociclib in combination with either letrozole or fulvestrant with a first dose initiated between June 2016 and December 2018 and followed their disease course until 30 April 2020. Results: The median PFS for all clinic patients receiving palbociclib and letrozole (n = 63) was 40.8 months (95% confidence interval (CI) 25.6–not estimable) and 16.97 months (95% CI 8.57–not estimable) for patients receiving palbociclib and fulvestrant (n = 11). We identified seven alternative dosing strategies prescribed by oncologists, the most prevalent being prescribing palbociclib for three weeks on and two weeks off (n = 8). The Kaplan–Meier curves for PFS in patients receiving letrozole and palbociclib prescribed alternative dosing strategies appear to diverge from monograph dosing early in the treatment. Many patients prescribed palbociclib using alternative dosing strategies continued to be observed even by the 18-month timepoint. The prevalence of grade 4 neutropenia was lower for patients on palbociclib with letrozole, suggesting a possible mitigation of severe neutropenia with alternative dosing strategies. Conclusions: We conclude that alternative dosing strategies used by oncologists such as prescribing palbociclib for three weeks on, two weeks off may achieve comparable disease control while mitigating neutropenic toxicities when compared to standard monograph dosing recommendations, prolonging treatment tolerability and adherence. Further large-scale studies are needed to confirm these results for future clinical adoption.