Miracle-dz/UniFAR-FTUs huggingface dataset:
MAGNETIC HARDENING OF EXCHANGE SPRING MULTILAYERS

Nanostructured permanent magnets have great potential for MEMS application, since it is possible to tailor their magnetic properties according to the specific requirements. In addition, hard magnetic / soft magnetic bilayers are excellent model systems to study fundamental magnetization processes both experimentally and numerically. The hysteresis properties of epitaxial SmCo/Co and SmCo/Fe bilayers are calculated by the solution of the Landau-Lifshitz Gilbert equation. The thin film grain structure is taken into account using appropriate finite element techniques. The J(H) curve shows the typical exchange spring behavior for a 10 nm Co-Sm / 10 nm Fe bilayer. However, the reversible rotations of the magnetization for low external field deteriorate the maximum energy density product. Straight B(H) curves are obtained only for a Fe layer thickness of 5 nm. The energy density products are 390 kJ/m3 for 10 nm Co-Sm / 10 nm Fe, 405 kJ/m3 for 10 nm Co-Sm / 5 nm Fe, and 644 kJ/m3 for 2.5 nm Co-Sm / 5 nm Fe. If the soft magnetic layer is sufficiently small exchange interactions keep the magnetization aligned even in strong opposing fields. Magnetization reversal starts with the reversible rotation of the soft layer magnetization. Initially, the magnetization rotates in opposite directions in different regions of the film. The reversible rotations penetrate substantially into the hard layer. Magnetization angles up to 30 degrees with respect to the easy axis are found in a depth of 1.5 nm. If the expense of exchange energy becomes to large a reversed domain nucleates and expands in the hard layer.
Promoting media literacy among older people

The aim of this study was to advance understanding of how to foster media literacy among older people. A systematic review was conducted of 40 empirical studies published between January 2005 and April 2019. The literature review provided information and practical implications for researchers, designers, and providers of media-literacy education for older people. Based on the review, it can be concluded that interventions aimed at fostering media literacy in older people need further development and creative enrichment in terms of aims, content, providers, recipients, and pedagogical approaches.
Mechanism of leukemic cell killing by IL-2 activated natural killer cells : role of cell adhesion molecules

Natural killer (NK) cells and lymphokine activated NK (LAK) cells, contribute to the elimination and growth control of malignant and virally infected cells. The binding of killer cells to their targets is a prerequisite for the lysis of malignant cells by NK cells, which utilize cell adhesion molecules (CAMs) to establish initial attachment to target cells. This thesis examined the possibility that defective expression of CAMs on some leukemic cells may be the primary cause of resistance to NK cell-mediated killing. To elucidate the mechanisms by which some leukemic cells are resistant to NK cytotoxicity, a model system was established with the human NK cell line NK-92, and the NK resistant leukemic cell line SR-91 which were established and characterized. SR-91 cells express very low levels of ICAM-1 and they failed to bind to NK-92 cells. NK-92 is highly cytotoxic and kills virtually all leukemic cell lines with the only exception being SR-91. Pre-treatment of SR-91 cells with TNF-a or IFN-y, two cytokines known to upregulate ICAM-1 expression, increased both ICAM-1 expression on SR-91 cells and binding to NK-92 cells. However, only TNF-a treated SR-91 cells became sensitive to killing by NK-92 cells. The increased binding to NK-92 cells and sensitivity to their killing were abrogated by anti-LFA-1 antibody or a combination of antibodies against ICAM-1, ICAM-2 and ICAM-3, indicating that LFA-1 interaction with the three ICAMs is essential for effector-target cell binding, which is a prerequisite for subsequent target cell lysis. These results underline the importance of ICAM-1 expression on the target cell SR-91 to allow adequate conjugate formation. However, this is, on its own, insufficient to allow target cell lysis by NK-92 cells. TNF-a, but not IFN-y, also induced the activation of LFA-1, CD44 and pi integrins on SR-91 cells.
A pathogenic variant in the transforming growth factor beta I (TGFBI) in four Iranian extended families segregating granular corneal dystrophy type II: A literature review

Objective(s): Granular and lattice corneal dystrophies (GCDs & LCDs) are autosomal dominant inherited disorders of the cornea. Due to genetic heterogeneity and large genes, unraveling the mutation is challenging. Materials and Methods: Patients underwent comprehensive clinical examination, and targeted next-generation sequencing (NGS) was used for mutation detection. Co-segregation and in silico analysis was accomplished. Results: Patients suffered from GCD. NGS disclosed a known pathogenic variant, c.371G>A (p.R124H), in exon 4 of TGFBI. The variant co-segregated with the phenotype in the family. Homozygous patients manifested with more severe phenotypes. Variable expressivity was observed among heterozygous patients. Conclusion: The results, in accordance with previous studies, indicate that the c.371G>A in TGFBI is associated with GCD. Some phenotypic variations are related to factors such as modifier genes, reduced penetrance and environmental effects.
CCIDE_A_263414 305..312

Naji Ziad Arandi 1 Tarek Rabi 1Department of Conservative Dentistry and Prosthodontics, Faculty of Dentistry, Arab American University, Jenin, Palestine; 2Department of Conservative and Prosthodontics, Faculty of Dentistry, Al-Quds University, Jerusalem, Palestine Objective: The aim of this paper was to review the current literature on cavity bases while focusing on the role of zinc oxide eugenol (ZOE) and resin-modified glass ionomers (RMGI) as cavity bases. Materials and Methods: A thorough literature search between 1970 and 2020 was done using Scopus, PubMed, and Google Scholar databases. The keywords of the search strategy were as below: cavity liners and bases, pulp protection, zinc oxide eugenol, and resinmodified glass ionomer. No specific inclusion or exclusion criteria were applied as to what articles would be included in this review. Conclusion: This review emphasizes that the available literature provides very little evidence to support the routine use of a base under amalgam or composite restorations. This review favors the adoption of “no more lining or bases” in shallow and moderate cavity preparations. However, an exception might be a “protective base” of RMGI following the application of calcium hydroxide (CH) liners in deep cavities. Bonded RMGIs are suitable cavity base materials and should always replace zinc oxide eugenol bases in daily practice.
Efficacy of saffron extract and fenugreek seeds supplementation on liver of streptozotocin induced diabetic rats

The present study aimed to investigate the possible hypoglycemic and hepatoprotective effects of saffron extract (100mg/kg b.wt) and fenugreek supplementation (1.4 g/day/kg b.wt) in STZ- induced diabetic rats at biochemical, histological, histochemical and ultrastructural levels. The results indicated that a single dose of STZ (50 mg /kg b wt, i.p) caused a significant increase in serum and liver total lipids, total cholesterol and triglyceride as well as serum low density and a very low density lipoprotein, accompanied by an increase in serum glucose level and oxidative stress marker, malondialdehyde and hydrogen peroxide level as well as serum aspartate and alanine aminotransferase activities. The results also reported a significant decrease in the high density lipoprotein, serum and liver total protein, serum albumin and globulin contents and A/G ratio, as well as a significant decrease in serum insulin level and the liver enzyme activities and the hepatic glutathione content. Histologically, STZ treated group showed degenerative changes in the pancreas and alteration in the structural integrity of the hepatocytes and their intracellular organelles. Histochemically, liver sections of STZ treated animals displayed marked decrease in the glycogen and total protein contents. On the other hand, the intake of saffron or fenugreek minimize the disturbance observed in the most tested parameters resulted from STZ administration and improve the liver structure and functions. Finally, it can be concluded that the intake of natural product such as saffron or fenugreek may be effective in reducing the diabetic liver injury induced by streptozotocin and the fenugreek supplementation showed more amelioration than saffron extract.
Teachers Efforts in Understanding the Factual, Conceptual, Procedural and Metacognitive Assessment Using the Revised 2013 Curriculum

This paper aims at analysing the efforts of forty teachers of the Madrasah Tsanawiyah School in Indonesia in understanding the Revised 2013 Curriculum (RC-13), particularly on how to implement the Factual, Conceptual, Procedural, and Metacognitive (FCPM) knowledge dimensions in assessments. This case study was carried out using the lecturing, discussion and implementation (LDI) approach to understand the RC-13 conceptually, discuss teachers’ problems and implement assessments using FCPM. The results of an in-depth observation and data analysis indicated that 30 out of 40 participants gained a better understanding on the RC-13 concept. They are now in a better position to know what should be done to prepare their RC-based instructional programs and they are conceptually able to implement the RC-13, except for the metacognitive dimension. The ten other teachers are still having some difficulties with FCPM as they did not have real classes such as Guidance Counselling, Sport and Health, and Scouting teachers. The results imply that teachers must be proactively trained to continually update their knowledge, particularly on curriculum development so that the quality of education can be improved. https://doi.org/10.26803/ijlter.19. 5.11
Case of Complete Remission from Palliative Radiation in Extensive Stage Small Cell Lung Cancer With Large Brain Metastasis Nine Years After Diagnosis: Cure Is Possible

Extensive stage small cell lung cancer (ES-SCLC) with symptomatic brain metastasis (BM) carries very poor prognosis with a median survival of only three to four months. This case shows the potential benefit of offering aggressive multimodality treatment to achieve the best quality of life and to improve survival. A complete response (CR) was achieved following craniotomy, whole brain irradiation (WBI), palliative chemotherapy, and palliative consolidative thoracic radiotherapy (CTRT) for ES-SCLC with large symptomatic BM. There was no residual cancer or further metastasis seen on CT imaging. The patient remains cancer free and asymptomatic nine years after the initial diagnosis.
Glutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice

Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice. Materials and Methods: Thirty mice were randomly assigned into control, model, LY294002 (PI3K/Akt inhibitor), Gln, Gln+LY294002 and 5-Aminosalicylic acid (5-ASA) groups. The mice in the experimental group drank 4% dextran sulfate sodium salt (DSS) for 7 consecutive days. The protective effect of Gln on oxidative stress was quantified by keeping colitis mice, involving Phosphatidylinositol-3-kinase (PI3K)/Protein kinase B (Akt)/mammalian target of Rapamycin (mTOR) signaling pathway, with different medications or distilled water through intragastric administration for 10 consecutive days. Results: In vivo administration of Gln, LY294002 or 5-ASA was found to ameliorate the symptoms of colitis in mice, such as reduced growth, loose stools and stool bleeding; protected DSS-induced colitis mice from goblet cell loss, lymphocytosis, mucosal erosion, loss of crypts, and neutrophil infiltration; improved the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-XP); decreased the content of malondialdehyde (MDA); and inhibited the activation of PI3K/Akt signaling pathway. Conclusion: Administration of Gln to the DSS-induced colitis mice led to a clearly reduction in oxidative stress-induced injury. The Gln is confirmed as inhibiting the PI3K/Akt signaling pathway activity.
Spatial competition between grasses: rates of mutual invasion between four species and the interaction with grazing

Monoculture turves of four grasses, Festuca rubra, F. arundinacea, Lolium perenne and Poa pratensis, were grown in adjacent plots in all permutations of two species. This experiment was nested within the treatments of a grazing experiment with sheep that factorially combined three grazing treatments in a complete block design. The invasion of each grass species into its neighbour was measured by counting tillers that crossed the interface between species. The invasion of the experimental turves by Agrostis stolonifera from the native sward was also measured. Grazing treatments affected the invasion rate of experimental species as a whole. Species differed in their invasion rates, and there was a significant interaction of grazing treatments x species (.)
Comparison of Two Blended Animal-Vegetable Fats Having Low or High Free Fatty Acid Content

Abstract A study was conducted to compare the feeding value of two blended animal-vegetable fats having different levels of free fatty acids (FFA) but similar fatty acid profiles and unsaturated:saturated (U:S) fatty acid ratios. One contained 29.8% FFA (AV-LO), while the other contained 44.7% FFA (AV-HI). Poultry oil (PO) and corn oil (CO) were fed as reference standards. Diets had 4, 6, or 8% supplemental CO, adjusting nutrient levels to dietary energy. Other fat sources were substituted for CO on a wt/wt basis. Each treatment was fed to four replicate pens of fifty male broilers from day-old to 42 days of age. There were no significant differences between the two blended fat sources in body weight, feed utilization, calorie:gain ratio, or mortality at 21 or 42 days of age. Body weight of birds fed the two blended fat sources was significantly less than that of birds fed PO at 21 days, but did not differ significantly at 42 days of age. Results of this study indicate that blended animal-vegetable fats with fatty acid profiles and U:S ratios similar to PO resulted in similar performance; the FFA level of these blended fats did not adversely influence performance of the broilers.
Experimental Crossing of Mountain Pine Beetle with Black Hills Beetle

There has long been a controversy as to whether Dendroctonus monticolae Hopk. and D. ponderosae llokp. , should be considered as one or as two species. The two bark beetles were originally described by A. D. Hopkins from widely separated areas. Hopkins (1902) named and briefly described D. ponderosae , and later, in referring D. monticolae (Hopkins 1905) he indicated how the two species may be distinguished morphologically. Hopkins (1909) gave detailed descriptions of the adults and immature forms of both species.
The Effect of Algebra Finger- Based Brain Gym Method to Improve Student Learning Outcomes

This study aims to look at the effect of algebraic finger-based brain gym methods on improving student learning outcomes. This study uses grade VII students MTs. Al-Hidayat Gerning consisting of 4 (four) classes as population, then by cluster random sampling technique obtained class VII A and VII B as research samples. This study uses a quasi-experimental method, the independent variable is the algebraic finger-based brain gym method and the dependent variable is the increase in learning outcomes. Data collection using test techniques, with the research instrument in the form of a matter of description which amounted to 6 questions that have been tested for validity, reliability, level of difficulty, and different power. Data analysis was performed using a t-test of 2 uncorrelated samples. The results revealed that the algebraic finger-based brain gym method has an influence on improving student learning outcomes. This is evidenced by the increase in student learning outcomes after learning with the algebra finger-based brain gym method obtained an average of 56.25 while the improvement in the learning outcomes of the control class gained an average of 37.50. After testing the hypothesis with t-test 2 uncorrelated samples obtained t count = 5.7774> t table = 2.0017. So it can be concluded that the algebraic finger-based brain gym method affects the improvement in student learning outcomes
Phosphorus affects high-molecular-weight glutenin subunits and glutenin macropolymer size distribution in wheat grains

SUMMARY Two winter wheat (Triticum aestivum L.) cultivars, Jimai20 and Shannong12, differing in phosphorus (P) utilization efficiency, were selected to study the effect of P application rate on changes in glutenin macropolymer (GMP) size distribution and the content of high-molecular-weight glutenin subunits (HMW-GS) in wheat grain. Four P levels (0, 40, 100 and 160 kg/ha) were applied under N1 (112·5 kg/ha) and N2 (225 kg/ha) conditions in the field, in 2008/09 and 2009/10. The results showed that increased P levels favoured HMW-GS synthesis under N1 conditions, but had a less pronounced effect under N2. When compared with the control, the volume proportions of <10 μm GMP particles in grains of both cultivars were significantly decreased, and those of >100 μm were increased in response to P application. The volume proportions of 10–100 μm GMP particles in the cultivars Jimai20 and Shannong12 were respectively lower and higher in response to P application than with no P fertilizer. At maturity, for both cultivars, total HMW-GS content was negatively correlated with GMP particle volume of <10 μm, but positively correlated with that of >100 μm. These observations suggest that both P and N affect protein synthesis in wheat grains and there exists a relationship between HMW-GS content and the synthesis of large GMP particles (>100 μm). The N×P interaction was the most important factor to regulate the HMW-GS and GMP contents.
European Journal of Foreign Language Teaching-ISSN 2501-1754

This one-group experimental study attempts to investigate the effects of integrating extensive reading, especially the integration of the two main reading skills namely skimming and scanning skills into the reading lessons on EFL high school students’ reading performance. The participants were 62 grade-10 students studying in a high school in the Mekong Delta, Vietnam. The four main instruments used to collect the data included Reading Tests (consisting of Pre-test and Post-test), a questionnaire, a semistructured interview, and a pre-program survey, respectively. The results of the data analysis indicated a relatively significant impact of extensive reading on students’ reading performance, especially the improvement of two reading skills, namely skimming and scanning. In addition, it confirmed that the participants had a positive attitude towards the integration of extensive reading into the reading lessons. The present study showed the main implication that the incorporation of extensive reading into the reading lessons should get more attention in language teaching programs at secondary education.
Modeling the distribution of a rare Amazonian odonate in relation to future deforestation

The advance of the deforestation frontier in the Amazon forest, the largest tropical forest and one of the richest ecosystems in the world, has threatened several plant and animal species. A lack of good biogeographical information of their distributions and a shortage of basic knowledge on their ecology hinder the proper evaluation of the vulnerability of those species. We used species distribution modeling techniques to fill these gaps and to estimate the vulnerability of a forest-dwelling odonate endemic from the Amazon, Diastatops nigra. We used the MaxEnt algorithm and compared the efficiency of this method in relation to the type of environmental data set (climate-only and climate+hydrographic environmental variables). We also estimated the decrease in extension of occurrence of D. nigra in relation to a recently developed model for future deforestation also produced with the MaxEnt approach. Predicted suitable areas were isolated patches in the central Amazon and many peripheral areas. In general, those areas had stable climates with low seasonality in rainfall. The Amazon deforestation frontier is expanding mainly from the south. The core area of D. nigra distribution is in the central Amazon, so in the short-term projection, the main threat for this species was not the deforestation itself. However, deforestation may extirpate some peripheral populations of this species and increase isolation among those patches of suitable areas. We suggest the use of this model for prioritizing future odonate inventories targeting the other species of the group.
Biopharmacotechnical and physical properties of solid pharmaceutical forms containing rutin commercially acquired in Juiz de Fora city, Brazil

Rutin is a flavonoid used in clinical practice to treat capillary fragility and prevent bleeding due to its wide variety of pharmacological actions, including antioxidant, anti-inflammatory, anti-allergic, antiproliferative, and anticarcinogenic activities. In this study, the biopharmacotechnical and physical properties of film-coated tablets containing rutin marketed in drugstores were evaluated. Using samples from three batches called A, B and C, we determined the average weight, disintegration time, hardness, content and dissolution profile, and kinetics of the tablets. The samples demonstrated average weight of 457.45 ± 12.32 to 449.15 ± 8.95 mg; disintegration time, 30.17 ± 2.14 to 15.17 ± 2.14 min; hardness, 1.92 ± 0.55 to 1.69 ± 0.36 Kgf; and rutin content, 18.34 ± 1.21 to 15.66 ± 1.29 mg. After 90 min, the dissolution profile showed 52.65, 41.80, and 79.2% for A, B, and C, respectively. The results imply that the non-conformities of the tested products can significantly compromise the drug’s therapeutic efficacy.