Miracle-dz/UniFAR-FTUs huggingface dataset:
Substantial global influence of anthropogenic aerosols on tropical cyclones over the past 40 years

Over the past 40 years, anthropogenic aerosols have been substantially decreasing over Europe and the United States owing to pollution control measures, whereas they have increased in South and East Asia because of the economic and industrial growth in these regions. However, it is not yet clear how the changes in anthropogenic aerosols have altered global tropical cyclone (TC) activity. In this study, we reveal that the decreases in aerosols over Europe and the United States have contributed to significant decreases in TCs over the Southern Hemisphere as well as increases in TCs over the North Atlantic, whereas the increases in aerosols in South and East Asia have exerted substantial decreases in TCs over the western North Pacific. These results suggest that how society controls future emissions of anthropogenic aerosols will exert a substantial impact on the world’s TC activity.
Role of adipose tissue macrophages in obesity-related disorders

As the first immune cells to colonize tissues and long-lived resident cells, macrophages play important roles in tissue functions during early development, homeostasis, and disease. Here, Chakarov et al. discuss macrophage origin and functions in adipose tissue and how these features are modulated in obesity.
Lower tumor burden is associated with better cognitive function in patients with chronic phase chronic myeloid leukemia

Abstract Cognitive function was assessed in patients with chronic myeloid leukemia in the chronic phase (CML-CP) receiving tyrosine kinase inhibitor (TKI) therapy using the Montreal Cognitive Assessment (MoCA). Cross-sectional assessments of 100 newly diagnosed patients and 584 patients receiving TKI therapy for >1 year showed that 31 (31.0%) and 191 (32.7%) patients had mild cognitive impairment, respectively. In the multivariable analyses, higher percentages of blood blasts were associated with a worse MoCA score at diagnosis [β = −0.29, 95% confidence interval (−0.54, −0.03), p = . 027]; deeper molecular response [versus < major molecular response, β = 0.74 (0.07, 1.40), p = . 029], better MoCA score on TKI therapy. Increased MoCA scores were observed after 12 months of TKI therapy in 42 patients who were regularly followed up (p = .005). Lower tumor burden is associated with better cognitive function in CML-CP patients both at diagnosis and during TKI therapy.
Investigating the severity of non-urban road traffic accidents in typical regions of Sichuan and Guizhou, China

Abstract Objective The traffic characteristics of Sichuan and Guizhou differ from those of other regions due to its unique geographical features. In addition, accident studies in China mainly focus on urban roads in the eastern and central regions. However, studies on western regions, especially non-urban roads, are scarce. Thus, this study aims to explore the factors that influence the severity of accidents on non-urban roads in typical regions of Sichuan and Guizhou. Methods A total of 541 cases from 2014 to 2020 were selected from the database of the China In-Depth Accident Study, where 18 variables, which may exert an impact on accident severity, were extracted after screening. First, heterogeneity of data was eliminated through latent class analysis (LCA). The ordered probit (OP) model was then conducted for each class to obtain significant variables that exert an impact on accident severity. The study quantified the degree of influence of the significant variables using marginal effect analysis. Results The LCA results demonstrate that data were categorized into the following classes, namely, (a) two-vehicle accidents involving trucks, (b) pedestrian and multiple-vehicle accidents, (c) two-wheeler accidents, and (d) single-vehicle accidents. The OP results show that most variables could exert impact on accident severity, and some of them exerted varying levels of influence on the severity of different classes, whereas others only influence a specific class. Conclusion According to this study, we obtained the accident characteristics of these regions and put forward some targeted suggestions to further improve the level of road traffic safety. The findings can provide support for the construction of transportation in line with the regional characteristics in China.
Blood transfusion in haematology: A qualitative exploration of patients’ and healthcare professionals’ perceptions

Abstract Objectives Repeated blood transfusions are indicated for the management of patients with cancer or blood disorders. Patients’ perceptions about transfusions may be associated with decision‐making and coping, which has been under‐explored in the haematology context. This study therefore aimed to explore haematology transfusion patients’ and HCPs’ perceptions of blood transfusion, drawing on theory and previously identified themes of transfusion perceptions. Design Semi‐structured interview study with 14 adult blood transfusion patients and 14 HCPs (consultants, registrars, nurses) at two UK haematology units. Methods Patient‐ and HCP‐tailored topic guides were developed based on themes of blood transfusion perceptions identified in a systematic review: ‘Health benefits’, ‘Safety/risk’, ‘Negative emotions’, ‘Alternatives’ ‘Decision making’ and ‘Necessity’. Transcripts were analysed using deductive and thematic analysis. Patient and HCP themes were compared using triangulation methods. Conceptual models (one for patients, one for HCPs) specific to haematology portraying the association between themes were developed. Results Findings for patients and HCPs converged with transfusion reported as beneficial for patients, who were largely involved in the decision‐making. Both groups also reported concerns about transfusion, including iron‐overload, allergic reactions and challenges to deliver transfusions in time‐pressurized services. Themes in the conceptual models included patient ‘Burden’ of receiving repeated transfusions and ‘Supportive relationships’, reflective of patients’ positive interactions with other patients and HCPs in the haematology unit. Conclusion Despite the challenges for patients receiving repeated transfusions, convergent perceptions suggest a shared understanding of patients’ transfusion experiences. Identified challenges could inform ways to improve transfusion services and patients’ experiences.
Comparison of neural basis expansion analysis for interpretable time series (N-BEATS) and recurrent neural networks for heart dysfunction classification

Objective. The primary purpose of this work is to analyze the ability of N-BEATS architecture for the problem of prediction and classification of electrocardiogram (ECG) signals. To achieve this, performance comparison with various types of other SotA (state-of-the-art) recurrent neural network architectures commonly used for such problems is conducted. Approach. Four architectures (N-BEATS, LSTM, LSTM with peepholes, GRU) were tested for performance and dimension reduction problems for different number of leads (2, 3, 4, 6, 12), both in variants consisting of blended branches, allowing retaining accuracy while reducing the computational capacity needed. The analysis was performed on datasets and using metrics from Challenges in Cardiology (CinC) 2021 competition. Main results. Best results were achieved for LSTM with peepholes, then LSTM, GRU and the worst for N-BEATS (challenge metrics respectively: 0.42, 0.40, 0.39, 0.35; for times: 0.0395 s, 0.0036 s, 0.0027 s, 0.0002 s). Commonly used LSTM outperforms N-BEATS in terms of multi-label classification, data set resilience, and obtained challenge metrics. Still, N-BEATS can obtain acceptable results for 2 lead classification (metric of 0.35 for N-BEATS and 0.38 for other networks) and outperforms other solutions in terms of complexity and speed. Significance. This paper features a novel approach of using the N-BEATS, which was previously used only for forecasting, to classify ECG signals with success. While N-BEATS multi-label classification capacity is lower than LSTM, its speed obtaining results with a reduced number of leads (faster by one to two degrees of magnitude) allows for arrhythmias detection and classification while using off-the-shelf wearable devices (Holter monitors, sport bands, etc).
Is the Femoral-Epiphyseal Acetabular Roof (FEAR) index associated with hip pain in patients with hip dysplasia?

Background Micro instability of the hip joint has been suggested to cause pain in patients with hip dysplasia. Recently, the Femoral-Epiphyseal Acetabular Roof (FEAR) index has been developed to evaluate hip instability in patients with dysplasia. Purpose To investigate associations between the FEAR index and patient-reported outcomes before and six months after periacetabular osteotomy (PAO). Material and Methods Radiographs of patients with hip dysplasia who underwent PAO between 2018 and 2020 were retrospectively assessed by a radiologist and an orthopedic surgeon. Radiographic measurements indicative of hip instability (Shenton's line, FEAR index, center-edge angle of Wiberg, acetabular index of Tönnis, and the femoral neck-shaft angle) were measured. Data on hip pain, function, and quality of life were collected prospectively using the Hip dysfunction and Osteoarthritis Outcome Score (HOOS). Results A total of 222 patients were included in the study. All radiographic measurements and patient-reported outcomes improved significantly from preoperative to six months postoperative (P < 0.001). There were no differences in the change score of patient-reported outcomes between patients with a FEAR index >2° (indicative of hip instability) and patients with a FEAR index ≤2°. Conclusion The FEAR index was not associated with hip pain, function, and quality of life among patients with hip dysplasia. This study did not find evidence supporting that instability defined by the FEAR index caused pain in patients with hip dysplasia.
Cross-coupling control for synchronized scan of experimental wafer and reticle stage

In the step & scan lithography system, the wafer stage and reticle stage should scan simultaneously at a high speed and the speed ratio is 1:4. The synchronization between the two stages has significant effect on the quality of exposure. The wafer stage is four times heavier than the wafer stage and the response speeds are different, which adds difficulty to the synchronization control system. After the construction of each stage motion control system, two kinds of synchronization control methods are applied. The first one is parallel mode, where both of the stages track on the command as accurate as possible. The second one is cross-coupling control, where one of the stages can get the information on the other one and compensate the following error. Because the response speed of reticle stage is faster than that of the wafer stage, the wafer stage's following error is feedback to the reticle stage's controller. Two kinds of synchronization methods are compared. Experiment shows that the cross-coupling controller can much increase the synchronization performance of the two stages.
Exploring the association between self-compassion, mindfulness and mindful eating with eating behaviours amongst patients with obesity

Background: People who have obesity often experience problematic eating behaviours, contributing towards their excessive weight gain. Aims: Understanding problematic eating behaviours and their association to self-compassion, mindfulness and mindful eating is important for the development of future interventions that improve weight-loss and weight-regulation. Methods: One hundred and one participants attending their first session of a 6-session dietetic programme within a Tier 3 medical weight management service in the West Midlands, UK were recruited to complete questionnaires on self-compassion, mindfulness, mindful eating and eating behaviours, such as, emotional, restrained, external, fat and sugar consumption and grazing. Results: The findings suggested all three constructs, self-compassion, mindfulness and mindful eating were significantly and negatively associated with grazing and emotional eating, but mindful eating was the only construct that also displayed a significant and negative association with other eating behaviours that are often barriers to successful weight regulation, such as external eating and fat consumption. Further investigation suggested mindful eating had an indirect effect on fat consumption and grazing via external eating. Conclusion: Whilst, self-compassion, mindfulness and mindful eating displayed a negative relationship with grazing and emotional eating, mindful eating also displayed a negative relationship with fat consumption and external eating. Possible explanations and directions for future work are discussed with an emphasis on the need for more empirical work.
Seven-month-old infants detect symmetrical structures in multi-featured abstract visual patterns

The present study investigated 7-month-old infants’ ability to perceive structural symmetry in mosaic-like abstract visual patterns. We examined infants’ (n = 98) spontaneous looking behaviour to mosaic-like sequences with symmetrical and asymmetrical structures. Sequences were composed of square tiles from two categories that differed in their colour scheme and internal shape. We manipulated sequence length (3 or 5 tiles) and abstractness of the symmetry (token vs. category level). The 7-month-olds discriminated structurally symmetrical from asymmetrical mosaics in the first half of the test phase (first 8 trials). Sequence length, level of symmetry, or number of unique tiles per sequence did not significantly modulate infants’ looking behaviour. These results suggest that very young infants detect differences in structural symmetry in multi-featured visual patterns.
Breaking the Cycle of Family Violence: A Critique of Family Violence Interventions

As the intergenerational transmission of family violence is associated with numerous negative outcomes, interventions are needed to interrupt this cycle. Our aim is to review the family violence intervention literature and to assess whether and how interventions interrupt the intergenerational transmission of family violence. Papers about interventions were identified through database searches (PubMed, JSTOR, CINAHL, PsycINFO), supplemented by review of references and relevant review papers. Eligibility criteria included: empirical studies detailing interventions to interrupt or prevent child abuse/maltreatment and/or intimate partner violence, published between January 2000 and August 2020, and written in English. Of the 14 papers included in this narrative review, only 3 explicitly stated that they aimed to break the cycle of family violence; 12 papers came from high-income countries, and 10 focused on individuals, with half focusing on mothers. We identify effective intervention approaches, including long-term one-on-one coaching and home visits to improve parenting. Results demonstrate a dose–response relationship, suggesting the lasting value of increased intervention frequency and duration. We highlight gaps in the literature, including the need for interventions in low-income countries, and those geared toward fathers and neighborhoods/communities. We also examine the many methodological challenges of this work, such as possible biases related to the use of retrospective data, lack of objective outcome measures, and absence of long-term follow-up. Our recommendations for future research include incorporating trauma-informed frameworks, developing standardized definitions and measures to facilitate the comparison of intervention results, and designing more interventions specifically for fathers/husbands and for the prevention of intimate partner violence.
Stable Lead-free Tin Halide Perovskite with Operational Stability >1200 h by Suppressing Tin(II) Oxidation.

Sn-based perovskites are the most promising alternative materials for Pb-based perovskites to address the toxicity problem of lead. However, the development of Sn (II)-based perovskites has been hindered by their extreme instability. Here, we synthesized efficient and stable lead-free Cs4SnBr6 perovskite by using SnF2 as tin source instead of easily oxidized SnBr2. The SnF2 configures fluorine rich environment, which can not only suppress the oxidation of Sn2+ in synthesis, but also construct chemically stable Sn-F coordination to hinder the electron transfer from Sn2+ to oxygen within the long-term operation process. The SnF2 derived Cs4SnBr6 perovskite shows high photoluminescence quantum yield of 62.8%, and excellent stability against oxygen, moisture, and light radiation for 1200 h, representing one of the most stable lead-free perovskites. The results pave a new pathway to enhance the optical properties and stability of lead-free perovskite for high-performance light emitters.
Association between baseline body mass index and survival in men with metastatic hormone‐sensitive prostate cancer: ECOG‐ACRIN CHAARTED E3805

E3805 (CHAARTED) is a phase 3 trial demonstrating improved survival for men with metastatic hormone‐sensitive prostate cancer (mHSPC) randomized to treatment with docetaxel (D) and androgen‐deprivation therapy (ADT) versus ADT alone. We assessed the association of baseline body mass index (BMI) and metformin exposure with quality of life (QOL) and prostate cancer outcomes including survival in patients enrolled in the CHAARTED study.
Magnitude and Associated Factors of Thrombocytopenia among Pregnant Women Attending Antenatal Care Clinics at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Background Thrombocytopenia is a common hematological abnormality during gestation. Pregnant women with severe thrombocytopenia may be associated with a higher risk of excessive bleeding during or after delivery. Therefore, the main aim of this study was to assess the magnitude and associated factors of thrombocytopenia among pregnant women attending antenatal care services at Dessie comprehensive and specialized hospital, Northeast Ethiopia. Methods An institution-based cross-sectional study was conducted from February to March 2021. Using a systematic random sampling technique, a total of 294 pregnant women were enrolled in the study. Structured interviewer-administered questionnaires were used to collect socio-demographic and clinical data of study participants. Four ml of venous blood were collected from each pregnant woman and a complete blood count was determined using DIRUI BF 6500 automated hematology analyzer. Data were entered into Epidata version 4.6. 0 and then exported into SPSS version 24.0. Multivariate logistic regression was used to assess the association between dependent and independent variables. P-value < 0.05 was considered to be statistically significant. Results A total of 294 pregnant women who visited antenatal care services at Dessie comprehensive specialized hospital were included. The mean (±SD) age of the study participants was 29.7 (±6.1) years. The prevalence of thrombocytopenia among pregnant women was 9.9% (95% CI: 6.5, 13.6). A mild type of thrombocytopenia is the major type and accounted for 72.4% whereas moderate thrombocytopenia and severe thrombocytopenia accounted for 17.2% and 10.4% respectively among pregnant women. Multivariate logistic regression showed that urban residents (AOR: 0.206,95% CI, 0.055-0.748), gestational ages within the first trimester (AOR: 0.183, 95% CI, 0.057-0.593) and gestational ages within the second trimester (AOR = 0.264, 95% CI, 0.092-0.752) were significantly associated and independent predictors of thrombocytopenia in pregnant women. Conclusion In this study, the prevalence of thrombocytopenia was 9.9% and the mild type of thrombocytopenia (72.4%) was higher than the other type of thrombocytopenia among pregnant women. In multivariate logistic regression analysis, residence and gestational age (trimester) were significantly associated with thrombocytopenia. Therefore, the platelet count should be routinely determined during the antenatal care visit for proper diagnosis and to minimize bleeding during and or after childbirth.
Dynamic Event-Triggered Formation Control for Heterogeneous Multiagent Systems With Nonautonomous Leader Agent

In this article, the time-varying output formation issue of heterogeneous multiagent systems is investigated by the event-triggered control scheme. Only the outputs of all agents, including leader agent and follower agents, are measurable. The leader agent contains an unknown input signal to generate flexible reference trajectory. Also, only a subset of follower agents have the direct access to the leader agent. First, for each follower, the leader-state compensator is designed to estimate the state of leader. Two kinds of dynamic event-triggered (DET) mechanisms, i.e., node- and edge-based event-triggered schemes, can be equipped on the compensator to save the communication bandwidth of leader–follower and follower–follower interactions, respectively. Then, the distributed formation controller is built to drive each follower achieving formation tracking. The presented control protocol consisting of the DET state compensator and formation controller is fully distributed, which is independent of the global information of communication topology, such as the eigenvalues of Laplacian matrix of communication topology and amount of whole agents. Finally, the numerical experiments and comparison experiments are exhibited to verify the effectiveness of the presented control protocol.
Increased COX‐2 after ureter obstruction attenuates fibrosis and is associated with EP2 receptor upregulation in mouse and human kidney

Cyclooxygenase‐2 (COX‐2) activity protects against oxidative stress and apoptosis early in experimental kidney injury. The present study was designed to test the hypothesis that COX‐2 activity attenuates fibrosis and preserves microvasculature in injured kidney. The murine unilateral ureteral‐obstruction (UUO) model of kidney fibrosis was employed and compared with human nephrectomy tissue with and without chronic hydronephrosis.