Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative Advantage Analysis of Main Crops in Chongqing

To study the comparative advantage of main crops in Chongqing,the changing trends of cultivated area and per unit yields of main crops were analyzed first,to explore the changing trend of production of main crops in Chongqing from 2005to 2011,then the comprehensive comparative advantages indices method was used to analyze the efficiency advantage,scale advantage,comprehensive advantage of ten kinds of main crops in Chongqing.The results showed that an order of efficiency the comparative advantage arranged from maximum to minimum was rice,soybean,potato,corn,rapeseed,tobacco;an order of the scale comparative advantage arranged from maximum to minimum was potato,tobacco, vegetable,rapeseed,rice;an order of the comprehensive comparative advantage arranged from maximum to minimum was potato,tobacco,rice,vegetable,rapeseed.In the end,suggestions on adjusting the structure of crops planting in Chongqing were put forward.
PHYSIOLOGICAL CHANGES IN PITUITARY MORPHOLOGY IN LONGITUDINAL ASSOCIATION WITH AGE AND GENDER: AN IMAGING EVALUATION.

Pituitary gland being centre of all the endocrinal activity in the body is responsible for regulating the internal endocrinal milieu. This pea-sized gland situated at the base of the brain is protected by a bony enclosure called sella turcica. Before the advent of cross-sectional imaging, the sella used to be evaluated by radiographs. As Magnetic Resonance Imaging (MRI) is now fast becoming established as the modality of choice for evaluating the pituitary gland, it is therefore imperative to re-visit this area and evaluate the normal patterns of this gland to help identify the departures with confidence. With this objective in mind, the present study has been undertaken to evaluate the normal dimensions of pituitary gland in a cross-section of people across different age-groups and genders.
Time Scale Changes in the Water Quality of the Ganga River, India and Estimation of Suitability for Exotic and Hardy Fishes

The water quality of rivers is an issue of serious concern today. Rivers are heavily impacted due to their use for carrying off the industrial, municipal, agricultural and domestic effluents. Water samples were collected for the present study from the Ganga River at Kanpur, Allahabad and Varanasi sites, during the period 2011-2012. The minimum temperature (17°C) was recorded in winter season. The pH, TDS, EC, sulphate, phosphate, nitrate, BOD and COD values exhibited their minimum at Allahabad site. The chloride and dissolved oxygen were recorded minimum at Kanpur site while alkalinity and total hardness had their lowest values at Varanasi site. The water quality of the Kanpur site was very poor compared to Varanasi and Allahabad sites. However, the Ganga river waters could host some tolerant fish species such as the exotic Cyprinus carpio and Oreochromis niloticus and also catfishes. All these species are very hardy, in respect of poor water quality, thus they (exotic species) have powerfully invaded in degraded systems worldwide.
Study of genetic and non genetic factors affecting age at first calving and wet average in Mehsana buffaloes

Mehsana buffalo is one of the best dairy breed of buffalo in Gujarat state. The aim of this study was to analyse the effects of non-genetic factors on Age at first calving (AFC) and Wet average (WA). The data set comprised 12560 records up to three lactations of 7870 Mehsana buffaloes, sired by 200 bulls from 1989 to 2013 under field progeny testing programme of Dudhsagar Research and Development Association (DURDA), Dudhsagar Dairy, Mehsana. The least squares maximum likelihood (LSML) program was used for estimation of various non-genetic factors on AFC and WA. The least squares mean with standard error of AFC and WA were 1383.30±3.50 days and 7.00±0.22 lit. Highly significant (P<0.01) effect of season and period of birth was recorded on AFC however, effect of clusters on AFC was observed to be non-significant (P<0.05). Further, highly significant (P≤0.01) effect of all the non-genetic factors (parities, season of calving, clusters, period of calving and age at first calving group) under study was observed on wet average in Mehsana buffaloes. The heritability of AFC and WA were estimated as0.11±0.02 and 0.34±0.03 respectively. Heritability of traits are useful for prediction of genetic response to selection and measure for accuracy in selection. Very high and significant estimate of heritability of WA. It was concluded that selection of Mehsana buffaloes may be based on this production trait in the herd.
A study on short momentum phenomenon

This study aimed at examining the phenomenon of short-term momentum in the Southeast Asian capital market. The sample capital markets were Singapore, Thailand, and Indonesia, with years of observation over the 2014 to 2016 period. Tests were carried out using the one-sample t-test to test whether there are abnormal returns on the winner and loser stock portfolios. The results of the study show that winner stock portfolios listed in the LQ45 (Indonesia), STI (Singapore), and SET50 (Thailand) indexes have positive and significant abnormal return results. While the testing of loser stock portfolios has a negative and significant average abnormal return.
Predictive modeling of organic pollutant leaching and transport behavior at the lysimeter and field scales

Soil and groundwater pollution has become a global issue since the advent of industrialization and mechanized agriculture. Some contaminants such as PAHs may persist in the subsurface for decades and centuries. In a bid to address these issues, protection of groundwater must be based on the quantification of potential threats to pollution at the subsurface which is often inaccessible. Risk assessment of groundwater pollution may however be strongly supported by applying processbased simulation models, which turn out to be particularly helpful with regard to longterm predictions, which cannot be undertaken by experiments. Such reliable predictions, however, can only be achieved if the used modeling tool is known to be applicable. The aim of this work was threefold. First, a source strength function was developed to describe the leaching behavior of point source organic contaminants and thereby acting as a time-dependent upper boundary condition for transport models. For general application of these functions dimensionless numbers known as Damköhler numbers were used to characterize the reaction of the pollutants with the solid matrix. Two functions were derived and have been incorporated into an Excel worksheet to act as a practical aid in the quantification of leaching behavior of organic contaminant in seepage water prognoses. Second, the process based model tool SMART, which is well validated for laboratory scale data, was applied to lysimeter scale data from two research centres, FZJ (Jülich) and GSF (München) for long term predictions. Results from pure forward model runs show a fairly good correlation with the measured data. Finally, the derived source term functions in combination with the SMART model were used to assess groundwater vulnerability beneath a typical landfill at Kwabenya in Ghana. The predicted breakthrough time after leaking from the landfill was more than 200 years considering the operational time of the facility (30 years). Considering contaminant degradation, the landfill would therefore not cause groundwater pollution under the simulated scenarios and the SMART model can be used to establish waste acceptance criteria for organic contaminants in the landfill at Kwabenya.
Dimeric Tubulin Modifies Mechanical Properties of Lipid Bilayer, as Probed Using Gramicidin A Channel

Using the gramicidin A channel as a molecular probe, we show that tubulin binding to planar lipid membranes changes the channel kinetics—seen as an increase in the lifetime of the channel dimer—and thus points towards modification of the membrane’s mechanical properties. The effect is more pronounced in the presence of non-lamellar lipids in the lipid mixture used for membrane formation. To interpret these findings, we propose that tubulin binding redistributes the lateral pressure of lipid packing along the membrane depth, making it closer to the profile expected for lamellar lipids. This redistribution happens because tubulin perturbs the lipid headgroup spacing to reach the membrane’s hydrophobic core via its amphiphilic α-helical domain. Specifically, it increases the forces of repulsion between the lipid headgroups and reduces such forces in the hydrophobic region. We suggest that the effect is reciprocal, meaning that alterations in lipid bilayer mechanics caused by membrane remodeling during cell proliferation in disease and development may also modulate tubulin membrane binding, thus exerting regulatory functions. One of those functions includes the regulation of protein–protein interactions at the membrane surface, as exemplified by VDAC complexation with tubulin.
El paisaje en la formación de maestros, un recurso educativo de alto interés para la educación primaria

The landscape, due to its crosswise and comprehensive character, constitutes a point of interest of first significance in primary education, and this is confirmed in the exhaustive scientific literature about the topic. Because of this, it must be an important part in the training of teachers. In this article we show a collection of samples of activities articulated around the landscape and focused on the acquisition of different competences, abilities and skills.
Plant-Produced Viral Nanoparticles as a Functionalized Catalytic Support for Metabolic Engineering

Substrate channeling could be very useful for plant metabolic engineering; hence, we propose that functionalized supramolecular self-assembly scaffolds can act as enzymatic hubs able to perform reactions in close contiguity. Virus nanoparticles (VNPs) offer an opportunity in this context, and we present a functionalization strategy to display different enzymes on the outer surface of three different VNPs produced in plants. Tomato bushy stunt virus (TBSV) and Potato virus X (PVX) plant viruses were functionalized by the genetic fusion of the E-coil peptide coding sequence to their respective coat proteins genes, while the enzyme lichenase was tagged with the K-coil peptide. Immobilized E-coil VNPs were able to interact in vitro with the plant-produced functionalized lichenase, and catalysis was demonstrated by employing a lichenase assay. To prove this concept in planta, the Hepatitis B core (HBc) virus-like particles (VLPs) were similarly functionalized by genetic fusion with the E-coil sequence, while acyl-activating enzyme 1, olivetolic acid synthase, and olivetolic acid cyclase enzymes were tagged with the K-coil. The transient co-expression of the K-coil-enzymes together with E-coil-VLPs allowed the establishment of the heterologous cannabinoid precursor biosynthetic pathway. Noteworthy, a significantly higher yield of olivetolic acid glucoside was achieved when the scaffold E-coil-VLPs were employed.
Long-term effects of fertilisers and organic sources on soil organic carbon fractions under a rice–wheat system in the Indo-Gangetic Plains of north-west India

Decline in soil organic carbon (SOC) content is considered a key constraint for sustenance of rice–wheat system (RWS) productivity in the Indo-Gangetic Plain region. We, therefore, studied the effects of fertilisers and manures on SOC pools, and their relationships with crop yields after 18 years of continuous RWS. Total organic C increased significantly with the integrated use of fertilisers and organic sources (from 13 to 16.03gkg–1) compared with unfertilised control (11.5gkg–1) or sole fertiliser (NPKZn; 12.17gkg–1) treatment at 0–7.5cm soil depth. Averaged across soil depths, labile fractions like microbial biomass C (MBC) and permanganate-oxidisable C (PmOC) were generally higher in treatments that received farmyard manure (FYM), sulfitation pressmud (SPM) or green gram residue (GR) along with NPK fertiliser, ranging from 192 to 276mgkg–1 and from 0.60 to 0.75gkg–1 respectively compared with NPKZn and NPK+cereal residue (CR) treatments, in which MBC and PmOC ranged from 118 to 170mgkg–1 and from 0.43 to 0.57gkg–1 respectively. Oxidisable organic C fractions revealed that very labile C and labile C fractions were much larger in the NPK+FYM or NPK+GR+FYM treatments, whereas the less-labile C and non-labile C fractions were larger under control and NPK+CR treatments. On average, Walkley–Black C, PmOC and MBC contributed 29–46%, 4.7–6.6% and 1.16–2.40% towards TOC respectively. Integrated plant nutrient supply options, except NPK+CR, also produced sustainable high yields of RWS.
A Software-Based Low-Latency Elliptic Curve Cryptography Design Over Prime Fields

This paper presents an innovative approach that enhances arithmetic operations in elliptic curve cryptography (ECC) over prime fields. By strategically integrating an efficient point multiplication algorithm into ECC, we achieve a substantial acceleration in the speed and efficiency of encryption and decryption processes. This improvement is further amplified by concurrent parallel execution of arithmetic operations, resulting in a significant reduction in encryption and decryption processing times. Empirical evaluations conducted across diverse datasets unequivocally validate the effectiveness of the proposed algorithm, demonstrating a remarkable acceleration of up to 23% and 40% in encryption and decryption operations, respectively. This research not only contributes to the advancement of ECC but also holds profound implications for the broader cryptographic landscape, establishing a compelling foundation for secure data communication and digital privacy.
Comprehensive Elucidation of the Role of L and 2A Security Proteins on Cell Death during EMCV Infection

The EMCV L and 2A proteins are virulence factors that counteract host cell defense mechanisms. Both L and 2A exhibit antiapoptotic properties, but the available data were obtained in different cell lines and under incomparable conditions. This study is aimed at checking the role of these proteins in the choice of cell death type in three different cell lines using three mutants of EMCV lacking functional L, 2A, and both proteins together. We have found that both L and 2A are non-essential for viral replication in HeLa, BHK, and RD cell lines, as evidenced by the viability of the virus in the absence of both functional proteins. L-deficient infection led to the apoptotic death of HeLa and RD cells, and the necrotic death of BHK cells. 2A-deficient infection induced apoptosis in BHK and RD cells. Infection of HeLa cells with the 2A-deficient mutant was finalized with exclusive caspase-dependent death with membrane permeabilization, morphologically similar to pyroptosis. We also demonstrated that inactivation of both proteins, along with caspase inhibition, delayed cell death progression. The results obtained demonstrate that proteins L and 2A play a critical role in choosing the path of cell death during infection, but the result of their influence depends on the properties of the host cells.
Applications Used to Increase the Accuracy Rate of Transthoracic Lung Biopsies Performed in Centers for Molecular Biological Diagnosis and Targeted Therapy for Oncology

Purpose This study aims to assess the significance of imaging techniques and needle thickness employed in transthoracic core needle biopsy for determining the cancer type and subtypes, ultimately guiding the treatment of lung cancer. Material and methods Between 2018 and 2023, a cohort of 350 patients (69.7% male, 30.3% female) underwent CT-guided lung biopsy, predominantly utilizing core biopsies. Fine needle aspiration biopsies employed 18 or 20 G Chiba needles, while core needle biopsies utilized 16 or 18-gauge coaxial system semi-automatic needles. The preferred needle and biopsy sample size were 16 G in thickness and 2 cm in length. Pre-procedure positron emission tomography-computed tomography (PET-CT) images aided in identifying the most homogenous lesion with the highest SUV max value, guiding biopsy sample extraction. Post-procedure control CT evaluated complications according to the Society of Interventional Radiology (SIR) reporting standard. Results The average age of biopsied patients was 65.48 +/- 12.32 SD (range: 18-90). Tru-cut biopsy was predominant (69.7%), utilizing a larger number of 16G needles. Pathological diagnoses were mostly malignant (76.6%), with lesion sizes averaging 35.98 +/- 17.90 SD (range: 5-105 mm) and distances to pleura averaging 13.48 +/- 13.54 SD (range: 0-86 mm). Malignancy prevalence was higher in males (56.8%), tru-cut biopsies (72.7%), 16G needles used for tru-cut (47.7%), and PET-CT evaluation (59.1%). Complications were identified in 22% of cases, with distance to pleura significantly associated (p < 0.001). No significant differences in complication risk were observed between FNAB and tru-cut and between needle gauges (20 G-18 G and 16 G) (p: 0.734, p: 0.638, respectively). Conclusion The study underscores the paramount importance of biopsy sample size in diagnosing lung cancers and determining targeted therapy. Optimal biopsy localization, informed by pre-procedure imaging techniques, is crucial. Hence, the recommendation is to utilize the thickest needles and largest samples for lung biopsies.
Comparison of Efficacy and Safety of First-Line Treatment Options for Unresectable Stage III Non-Small Cell Lung Cancer: A Retrospective Analysis

Background Based on PACIFIC trial, durvalumab as consolidation therapy following concurrent chemoradiotherapy (cCRT) has been a new standard treatment for unresectable stage III non-small cell lung cancer (NSCLC). In clinical applications, there are heterogeneous adjustments or novel strategies following specialized discussions in experienced multidisciplinary teams. This study retrospectively compared the efficacy and safety of different first-line treatments for unresectable stage III NSCLC. Methods We retrospectively analyzed 397 patients who received first-line treatment for unresectable stage III NSCLC. Comparisons and statistical analyses of treatment were made in terms of efficacy and safety. Adverse events and responses were assessed using CTCAE v5.0 and RECIST v1.1. The progression-free survival (PFS) was estimated using the Kaplan–Meier method or the Cox survival regression model and compared using the log-rank test. Results In wild-type driver genes group, the objective response rate (ORR), disease control rate (DCR), and median PFS (mPFS) were prolonged in the radiotherapy group compared to those in the nonradiotherapy group (ORR: 50.94% vs. 30.06%, p < 0.001; DCR: 98.11% vs. 80.37%, p < 0.001; and mPFS: 21.00 vs. 8.20 months, p < 0.001). The incidence of pneumonia at any grade in the radiotherapy group was higher than that in the nonradiotherapy group (9.43% vs. 2.45%, p = 0.008). In the radiotherapy group, the chemoradiotherapy (CRT) plus immunotherapy subgroup had longer mPFS than the CRT subgroup, with increased toxicity at any grade (24.60 vs. 17.90 months, p = 0.025, and 83.17% vs. 65.52%, p = 0.011). In the nonradiotherapy group, the DCR and mPFS were higher in the chemotherapy plus immunotherapy subgroup than in the chemotherapy subgroup, with increased toxicity at any grade (DCR: 93.67% vs. 67.86%, p < 0.001; mPFS: 13.53 vs. 5.07 months, p < 0.001; and 68.35% vs. 41.67%, p = 0.001). In the mutant driver genes group, the efficacy did not significantly differ among the radiotherapy subgroup, targeted therapy subgroup, and radiotherapy plus targeted therapy subgroup (ORR: p = 0.633; mPFS: p = 0.450). Conclusions For unresectable stage III NSCLC patients with wild-type driver genes, the combination of radiotherapy and immunotherapy in the initial treatment was essential to significantly improve the efficacy. For patients with mutant driver genes, radiotherapy, targeted therapy, and the combination of radiotherapy and targeted therapy showed similar short-term efficacy.
Phage Display’s Prospects for Early Diagnosis of Prostate Cancer

Prostate cancer (PC) is the second most diagnosed cancer among men. It was observed that early diagnosis of disease is highly beneficial for the survival of cancer patients. Therefore, the extension and increasing quality of life of PC patients can be achieved by broadening the cancer screening programs that are aimed at the identification of cancer manifestation in patients at earlier stages, before they demonstrate well-understood signs of the disease. Therefore, there is an urgent need for standard, sensitive, robust, and commonly available screening and diagnosis tools for the identification of early signs of cancer pathologies. In this respect, the “Holy Grail” of cancer researchers and bioengineers for decades has been molecular sensing probes that would allow for the diagnosis, prognosis, and monitoring of cancer diseases via their interaction with cell-secreted and cell-associated PC biomarkers, e.g., PSA and PSMA, respectively. At present, most PSA tests are performed at centralized laboratories using high-throughput total PSA immune analyzers, which are suitable for dedicated laboratories and are not readily available for broad health screenings. Therefore, the current trend in the detection of PC is the development of portable biosensors for mobile laboratories and individual use. Phage display, since its conception by George Smith in 1985, has emerged as a premier tool in molecular biology with widespread application. This review describes the role of the molecular evolution and phage display paradigm in revolutionizing the methods for the early diagnosis and monitoring of PC.
The Middle Paleolithic of Southern Bahariya Oasis, WesternDesert, Egypt.

The georelief of southern Bahariya, shaped from the soft Tertiary sediments interlain by harder rocks, is structured into distinct 'floors" and thus offers good potentials for study of Middle Paleolithic settlement strategies. Three aspects are important for location of the sites: secure water resources, lithic raw material outcrops, and positions granting a good overview. Accordingly, several types of Middle Paleolithic sites may be defined: the cummulative settlements at the playas, lithic workshops on the mountains, strategic hunting posts, and individual artifact occurrences. Given the lack of chronological framework of the Bahariyan Middle Paleolithic, the only trend that may be recognized is the development from the bifacial Acheulian handaxes towards the fine leafpoints (the latter associated with Mousterian points and flat-retouched sidescrapers), and probably, a tendency to reduction in size of the cores and flakes. Contrary to the sites in Negev and Cyrenaica, the Middle Paleolithic of northern Egypt shows no trends towards an increased blade production and to Upper Paleolithic technology in general.
Patient safety culture assessment before and after safety huddle implementation

ABSTRACT Objective: To identify whether safety huddle implementation enabled a change in patient safety culture. Method: Quasi-experimental research that assessed patient safety culture before and after safety huddle implementation. Results. The study revealed that 53.98% completed the two safety culture assessments, with 60.1% adherence from the nursing team, with a statistically significant difference in the second assessment regarding perception of patient safety and adverse events notified (p < 0.00). Regarding good practice indicators, a statistically significant difference (p < 0.00) was observed in item 43 and improvement in almost all dimensions in the second safety culture assessment. The huddles totaled 105 days, with 100% adherence from the nursing team. Regarding checklist items, all presented satisfactory responses (above 50%). Conclusion: Safety huddles proved to be an effective tool for communication between healthcare professionals and managers, demonstrating positive impacts on good practice indicators and most safety culture dimensions.