Miracle-dz/UniFAR-FTUs huggingface dataset:
Additional possibilities of chimeric antigen receptor T-cells in B-cell lymphoma: combination therapy

B-cell non-Hodgkin’s lymphoma (B-NHL) is a lymphoproliferative disorder that affects B lymphocytes. Chimeric antigen receptor (CAR) T-cell immunotherapy is a new type of immunotherapy that uses genetic engineering techniques to modify and expand the patient’s autoimmune cells in vitro, after which these cells are reinfused into the patient. CAR-T cell immunotherapy has the potential to treat different types of B-cell lymphoma. Many clinical studies have shown that CAR-T cell therapy has significant antitumor effects on B-cell lymphoma. Although much work has been carried out to improve the efficacy of CAR-T cell therapy and to reduce associated side effects, there are still many issues to address. CAR-T cell therapy shows significant promise in treating B-NHL, but some patients still have a poor initial response to this therapy where the infused CAR-T cells show insufficient persistence. With the rapid development of immunological therapy, combination therapy has been certified to improve the efficacy of CAR-T cell therapy. Targeted drugs such as programmed death-1 (PD-1) inhibitors, programmed cell death-ligand 1 (PD-L1) inhibitors, and Bruton’s tyrosine kinase (BTK) inhibitors may further enhance the efficacy and reduce the side effects of CAR-T cell treatment. This article reviews the rationale and relevant clinical research on combination therapy based on CAR-T cell therapy for B-cell lymphoma treatment.
GAS PHASE CHEMISTRY OF SULFONATE ANIONS: BASICITIES AND FRAGMENTATION REACTIONS1

Abstract The gas phase relative acidities of 15 sulfonic acids, RSO3H, have been determine via Cooks' kinetic method. The following acidity scale was established (starting with the weakest acid): methane sulfonic acid < ethane sulfonic acid < methoxy sulfonic acid < sulfuric acid < m-aminobenzene sulfonic acid - p-aminobenzene sulfonic acids < p-toluene sulfonic acid < benzene sulfonic acid < o-aminobenzene sulfonic acid < 5-sulfosalicylic acid < o-nitrobenzene sulfonic acid < cysteic acid < m-aminobenzene sulfonic acid < p-nitrobenzene sulfonic acid < triflic acid. In addition the gas phase fragmentation reactions of the conjugate bases, the sulfonate anions RSO3 −, have been studied using MS/MS techniques. A general loss of R, resulting in the formation of the radical anion SO3,− is observed in all cases. Other fragmentation pathways are discussed in detail.
An investigation of the electrical properties of zinc oxide thin films influenced by oxygen adsorption

The resistance of a ZnO thin film deposited by rf sputtering exhibits a change of 2 1/2−5 orders of magnitude as the ambient gas is cycled from nitrogen to oxygen. Hall measurements imply that the sputtered films are n−type semiconductor and that the resistance increase caused by oxygen adsorption is related to the decrease of carrier density of the sample. Sample resistivity is found to change with thickness; in oxygen, it decreases as thickness increases, but in a vacuum, it increases as thickness increases. The response time for resistance changes vs environmental changes depends highly on the sample temperature; it is slow at room temperature, but a rapid response can be seen at temperatures higher then 365°C.
Evaluation of Medication Errors in Teaching Hospitals

Introduction: Medication errors (MEs) are a common explanation for iatrogenic adverse events. This study appraised the incidence of MEs and identified the error types in the hospitals affiliated to Azad University of Medical Sciences, located in Tehran, Iran. Materials and Methods: This cross-sectional descriptive study was conducted on all patients admitted to the hospitals affiliated to Azad University of Medical Sciences. The data were collected by means of a drug safety checklist and then extracted and analyzed in SPSS software (version 22.0). Moreover, drug interaction was assessed based on the World Health Organization guidelines and Medscape application. Results: The mean MEs incidence was obtained as 43.38±5.25. Moreover, the mean numbers of errors in prescribing drugs and antibiotics were 4.71±2.93 and 1.02±0.95, respectively. According to the results, drug interactions occurred in 12.3% of the medicines. In addition, ME showed a significant correlation with education status, ward type, admission type, hepatic failure, hepatic enzymes, patient weight (when on antibiotics), antibiotic effect, and patient age (65> years). Conclusion: The results were indicative of a high prevalence of prescription errors. Moreover, it was found that most of MEs were made by doctors, mainly due to the lack of an electronic drug registration system. Therefore, physicians need to be educated on how to increase patient safety through drug safety.
Do Good Corporate Governance and Financing Risk Management Matter for Islamic Banks’ Performance in Indonesia?

The purpose of this study is to examine and analyze the influence of the implementation of Good Corporate Governance principles and financing risk management on the Islamic banks' performance in Indonesia over the 2010-2019 period. 11 full-pledge Islamic Banks (BUS) was selected as the study sample using the purposive sampling technique and analyzed using the panel multiple regression techniques. The study found that Good Corporate Governance (GCG) and Financing to Deposit Ratio (FDR) positively influence the Islamic banks' performance. In contrast, Non-Performing Financing (NPF) has a negative influence on Islamic banks' performance. These findings imply that to promote the performance further, the Islamic banks should enhance the implementation of GCG principles and minimize NPF by improving financing risk management and enhance their financing by allocating their existing funds to the bankable and productive economic sectors.JEL Classification: G21, G34How to Cite:Maulidar, A. , & Majid, M. S. A. (2020). Do Good Corporate Governance and Financing Risk Management Matter for Islamic Banks’ Performance in Indonesia? Etikonomi: Jurnal Ekonomi, 19(2), xx – xx. https://doi.org/10.15408/etk.v19i2. 15080.
Budgeting Development Under Conditions of Digital Economy

The article gives a theoretical summary and suggests a new solution to the scientific problem regarding the substantiation of theoretical-methodical guidelines and development of practical recommendations on the improvement of organizational-methodical foundations of accounting and budgeting in the enterprise activity management system. The sophistication of the process of making effective managerial decisions due to the increasing degree of uncertainty of the external and internal economic environment conditions the need in rethinking of the role of budgeting in ensuring stable economic development of the enterprise. Based on the conducted retrospective analysis, the periodization of the historical development of budgeting was carried out, which confirmed the transition from the cost approach to understanding the content of budgeting (revenue and expenditure planning) to its perception as one of the subsystems of the overall enterprise management system. It is established that budgeting is an integral part of the enterprise management system, which is responsible for implementing efficient business activities and providing feedback between stages of the management process. Insufficient substantiation of the value of the budgeting process in the enterprise management system leads to a decrease in the quality of managerial decisions aimed at correction and improving the efficiency of the enterprise operation. In order to create a rational and flexible management system, it is proposed to introduce an integrated budgeting system in the activity of enterprises allowing to respond promptly to deviations from the planned budget indicators, which provides a qualitatively new level of planning and organization of internal (management) accounting with an orientation to the enterprise activity strategy. The introduction of an integrated budgeting system significantly increases the profitability of activities, helps identify areas of rational use of available resources, increase the solvency and investment attractiveness of the business entity based on improving the adaptability of the company to changes in the external and internal economic environment.
Evaluation of Evidence-based Teaching Techniques in a Graduate Fluid Dynamics Course

is an He specializes in multiphase thermo-ﬂuid ﬂows. Dr. Palmore’s technical research focuses on developing numerical algorithms for simulating these ﬂows using high performance computing. His educational research focuses upon incorporating technology into the classroom. Dr. Palmore is an active member of several professional societies including the American Institute of Aeronautics and Astronautics, the American Society of Mechanical Engineers, the Society for Industrial and Applied Mathematics, and the National Society of Black Engineers. Abstract This paper explores the use of modern, evidence-based teaching techniques in a graduate ﬂuid dynamics course. Evidence-based learning and teaching techniques have become increasingly popular in undergraduate engineering courses, however, there is less documentation of the efﬁcacy of the techniques in the graduate context. The study focuses on the use of three techniques that integrate well with the author’s focus on the use of computer technology in the classroom. The techniques are guided notes, peer discussions (using Piazza), and gamiﬁcation (using Kahoot! ). The efﬁcacy of the techniques in increasing student engagement with the course material and student understanding is self-assessed through a survey administered to the students at the end of the Fall 2019 semester. This assessment method is limited due to the small sample size studied (nine students), however, the data suggests that the use of these strategies may be helpful in student education. From the assessment, it was found that guided notes were considered helpful by students, and they were particularly helpful for studying. Online discussion using Piazza was not appreciated, however, the incorporation of discussion into the gamiﬁcation framework of Kahoot! was appreciated.
Controls on dolomitization in extensional basins: An example from the Derbyshire Platform, U.K.

Fault-controlled dolomitization has been documented in Lower Carboniferous (Viséan) platform carbonates at various localities in the Pennine Basin and North Wales. The largest of these dolomite bodies (approx. 60 km2) occurs on the Derbyshire Platform, on the southern margin of the Pennine Basin. This study tests the hypothesis that dolomitization occurred at this locality during deposition, platform drowning, and the earliest stages of burial, coincident with the transition from a late syn-rift to post-rift regime. It also assesses the importance of syn-rift volcanism on dolomitization. Planar, fabric-retentive dolomite with single-phase (i.e., low temperature) fluid inclusions occurs along NW–SE and E–W oriented faults, and in platform margin facies and in proximity to the Masson Hill Volcanic Complex. Oxygen isotope data are consistent with dolomitization from seawater, but slightly depleted δ13C values reflect mixing with magmatic fluids. Volcanic activity is likely to have produced a thermal drive for fluid circulation on the platform margin, and post-depositional alteration of basalts by CO2-rich fluids could have led to alteration of olivine and release of magnesium to convecting seawater. Consequently, the large volume of dolostone on the southern margin of the Derbyshire Platform is attributed to the increased geothermal gradient and a localized increase in the Mg/Ca ratio of dolomitizing fluids at this locality, compared to elsewhere in the Pennine Basin. The results suggest that syn-rift carbonate platforms in volcanically active areas of rift basins have a greater potential for dolomitization from seawater than non-volcanic platforms in the same basin.
The Effect of Cognitive Behavioral Therapy Group Counseling on the Well-Being of Self-Harming Emerging Adults

This study determined the effect of Cognitive Behavioral Therapy (CBT) group counseling on the psychological well-being of self-harming emerging adults. It utilized the pretest-posttest control group design. The Self-Harm Inventory (SHI) was used to determine self-harming emerging adults. There were no significant relationships among the socio-demographic variables and the level of severity of self-harm of 30 college students. The intervention was a four session CBT group counseling. The Depression, Anxiety, and Stress Scale – 21 (DASS-21) was used to measure psychological well-being. There were eight participants in the experimental group and nine participants in the control group. The results of the study revealed significant differences in the psychological well-being of the experimental group and the control group after the intervention. The findings suggest implications in school guidance and counseling programs to address the mental health issues of emerging adults.
Escala de liderazgo en entrenadores de fútbol: estudio psicométrico y descriptivo

Leadership has been one of the variables of interest in sport psychology. The Multidimensional Model of Leadership (Chelladurai and Saleh, 1980) was the basis for the creation of the Leadership Sport Scale (LSS-3), that presents debate regarding its factor structure and its reliability values. The main objective of this study was to offer an acceptable factorial solution for the LSS-3 scale in a sample of 326 soccer coaches -men, aged between 17 and 59 years- and assess its psychometric properties. The second objective was to explore the differences in the leadership sub-scales (Training and Instruction, Social Support, Positive Feedback, Democratic Behaviors and Autocratic Behaviors) according to the sports title, educational level and years of experience of the coaches. The exploratory analyzes of structural equations (ESEM) resulted in a scale with 33 items with 5 factors with good adjustment rates. The reliability obtained is excellent, except in the Autocratic Behavior scale. The coaches with more experience are the ones who score the most in Training and Instruction, while the coaches with the least education score higher in autocratic behavior. Depending on the sports title there are no differences
The complete mitochondrial genome of Robin Accentor Prunella rubeculoides (Passeriformes: Prunellidea)

Abstract In this paper, we determined and described the complete mitochondrial genome of Robin Accentor (Prunella rubeculoides), the first complete mitogenome. The complete genome of P. rubeculoides was 16,796 bp in length and contained 13 protein-coding genes, 22 transfer RNA genes, two ribosome RNA genes, and one non-coding control region. The overall base composition of the mitochondrial DNA was 29.7% for A, 23.7% for T, 15.6% for G, and 31.0% for C, with a GC content of 46.6%. This information of P. rubeculoides mitogenome is significance for phylogenetic studies of the family Prunellidea.
Asset Pricing with a CEO

We study an economy with a CEO who trades off the incentive to divert funds, which leads to underinvestment, against the incentive to overinvest based on his optimism. In equilibrium, we see overinvestment relative to what the shareholder or a social planner would implement but underinvestment relative to what the optimistic CEO would implement if there were no feedback between real investment and asset prices. For large wealth shares, the CEO's welfare is higher under a social planner where no funds can be diverted. For small wealth shares, overinvestment peaks and the real short-rate and Tobin's q decline.
A closer look into the ubiquitin corona on gold nanoparticles by computational studies

In this study, coarse-grained computational simulations of the ubiquitin corona around gold nanoparticles have been carried out, and the effect of the nanoparticle size (10, 16, 20, and 24 nm diameter) and environment (bare nanoparticle surface, and citrate-coated surface, where citrate are treated with implicit and explicit models) has been analysed. The results showed that the corona is obtained after a slow reorientation step that occurs at the nanoparticle surface in order to optimize the nanoparticle–ubiquitins interaction. The ubiquitin binding modalities depend on the nanoparticle environment, while conformational changes of ubiquitins upon binding and their aggregation propensity slightly depend on nanoparticle size.
LAND AND WATER CARRYING CAPACITY ON INDUSTRY ALLOCATION IN KENDAL REGENCY

The purpose of this study is to provide information and also clear and accurate pictures of the carrying capacity of land and water in the industrial designation in the Kendal Regency. The method of analysis used is system dynamics approach. The projection of calculation for the next 10 years (2021 - 2031) is a prediction of water demand which is known continues to increase. The availability of water in the Kendal Regency is still sufficient for the population's living and industrial needs during this period. The management of agriculture and plantations have taken several steps to maintain the function of land according to conservation aspects and to prevent degradation in order to keep the conservation area as a reservoir of natural water. The industrial estate area in Kendal Regency is 1,265,323 hectares which is consists of land for industry and trade, mixed gardens, fields, meadows, coastal sand, settlements, rice fields, fishponds and dryland agriculture.
A generalized model of heat effects in surface reactions. I. Model development

Many important classes of surface reactions exhibit both high heats of reaction and large, positive activation energies. In addition, many surface reactions often occur in thermally isolated environments. As a result, significant autothermic effects are possible. In part I of this article, a generalized model of these effects is presented which describes the enhancement in reaction rate as a function of activation energy, bulk temperature, and a parameter termed the characteristic temperature. Reactant concentration and reaction order effects are also considered. Part II of this work presents the application of this model to numerous experimental plasma etching data.
3, 4‐Dimethylpyrazole phosphate reduces nitrous oxide emissions from grassland after slurry application

Abstract. A field study was conducted to assess the effect of the nitrification inhibitor 3,4‐dimethylpyrazole phosphate (DMPP), applied at a rate of 1 kg ha−1, on nitrous oxide (N2O) emissions, forage production and N extraction from a grassland soil after cattle slurry applications in autumn and spring. Nitrous oxide emissions were measured daily or weekly using the closed chamber technique. DMPP efficiency after slurry application was lower in spring (16.7 °C mean soil temperature) than in autumn (11.4 °C mean soil temperature). Thus, DMPP was able to maintain soil mineral N in the ammonium form for 22 days and reduce cumulative N2O emissions by 69% in autumn, while in spring its effect on soil mineral N lasted for 7–14 days, reducing cumulative N2O losses by 48%. Furthermore, application of DMPP after slurry did not decrease biomass yield or N uptake.
Effect of Loan Default Rate on Financial Performance of Savings and Credit Cooperative Societies Innarok, County Kenya

In Kenya cooperative movement is one of the highly valued strategies used to enhance resource mobilisation and use. However, studies on factors that contribute to the performance of these cooperatives have produced mixed results that calls for further research in the same. This paper sought to further examine the effect of loan default rate on the financial performance of Savings and Credit Cooperative Societies in Narok County, Kenya. Financial performance was measured by use of return on asset and return on equity. Cross sectional research design was applied in this study. The target population comprised of 20 registered and active SACCOs in Narok County. Purpose sampling was used to select only 17 of the SACCOs which had been active for the six years period of the study. Secondary data from audited financial report between 2013 and 2018 was collected and used for the analysis. Both descriptive and inferential statistics were used to analyse the relationship between the variables. Statistical Package for Social Sciences version 23 and Microsoft Excel package were used as appropriate tool to analyse and present the results. The study hypothesis was tested at a 0.05 significant level. From the findings it was established that loan default rate had a positive statistical significant effect to financial performance of the SACCOs in Narok County. The null hypothesis on loan default rate was rejected as it had a p-value of less than 0.05. It was concluded that the rate of loan default among the SACCOs is a strong predictor of their financial performance. The study recommended that the SACCOs should put emphasis on ensuring members are able to repay their loans on time to enhance financial performance. The results are very significant and will go a long way to assist SACCOs to enhance their financial performance by re-assessing their loan advancement and recovery strategy among their members.
Prediction of Rheological Properties and Interfacial Tension of Mixtures of Immiscible Polypropylene-Polystyrene (PP3/PS) Blends

Blends of polypropylene (PP3) and polystyrene (PS) were studied and, their rheological behavior was determined and discussed in detail. The interfacial tension between the blend components was evaluated from the rheological data and the storage modulus by using two well-known models: Palierne model and Choi-Schowalter equation. The theoretical predictions were compared with experimental data obtained from PP3/PS blends. The obtained results showed that the Palierne model could predict the rheological and viscoelastic properties of the considered polymer blends. In addition, the interfacial tensions between PP3 and PS were evaluated and compared with those cited in the literature. It was also found that the Palierne model was more accurate than Choi-Schowalter one in determining the interfacial tension.
In vivo grafting of large engineered heart tissue patches for cardiac repair

Engineered heart tissue (EHT) strategies, by combining cells within a hydrogel matrix, may be a novel therapy for heart failure. EHTs restore cardiac function in rodent injury models, but more data are needed in clinically relevant settings. Accordingly, an upscaled EHT patch (2.5 cm × 1.5 cm × 1.5 mm) consisting of up to 20 million human induced pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) embedded in a fibrin-based hydrogel was developed. A rabbit myocardial infarction model was then established to test for feasibility and efficacy. Our data showed that hPSC-CMs in EHTs became more aligned over 28 days and had improved contraction kinetics and faster calcium transients. Blinded echocardiographic analysis revealed a significant improvement in function in infarcted hearts that received EHTs, along with reduction in infarct scar size by 35%. Vascularization from the host to the patch was observed at week 1 and stable to week 4, but electrical coupling between patch and host heart was not observed. In vivo telemetry recordings and ex vivo arrhythmia provocation protocols showed that the patch was not pro-arrhythmic. In summary, EHTs improved function and reduced scar size without causing arrhythmia, which may be due to the lack of electrical coupling between patch and host heart.