Miracle-dz/UniFAR-FTUs huggingface dataset:
Mediterranean Diet as a Shield against Male Infertility and Cancer Risk Induced by Environmental Pollutants: A Focus on Flavonoids

The role of environmental factors in influencing health status is well documented. Heavy metals, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls, dioxins, pesticides, ultrafine particles, produced by human activities put a strain on the body’s entire defense system. Therefore, together with public health measures, evidence-based individual resilience measures are necessary to mitigate cancer risk under environmental stress and to prevent reproductive dysfunction and non-communicable diseases; this is especially relevant for workers occupationally exposed to pollutants and/or populations residing in highly polluted areas. The Mediterranean diet is characterized by a high intake of fruits and vegetables rich in flavonoids, that can promote the elimination of pollutants in tissues and fluids and/or mitigate their effects through different mechanisms. In this review, we collected evidence from pre-clinical and clinical studies showing that the impairment of male fertility and gonadal development, as well as cancers of reproductive system, due to the exposure of organic and inorganic pollutants, may be counteracted by flavonoids.
Optimization of Salt-Leaching Parameters for Gelatin/Na2Ti3O7 Scaffolds Using a Mixture Design Experiment

The purpose of this research was to learn the formation of biomedical scaffold material from gelatin by using titanate (Na2Ti3O7), which is a newly synthesized derivative of titanium dioxide (TiO2) with gelatin. It was prepared by mixed several solutions and cross-linked molecules by heating and salt-leaching. The biomedical scaffold was formed, and its porosity depended on the size of the salt crystal. The mixture was designed by using a mixture design with three factors: gelatin, titanate, and deionized water to determine the optimal mixture for the tensile strength of the biomedical scaffold. The microstructure of the biomedical scaffold was studied using scanning electron microscopy (SEM). The findings revealed that Na2Ti3O7 thoroughly pen-extracted the biomedical scaffold, and the tensile strength of the gelatin/titanate scaffold was higher than the biomedical scaffold, which was formed using pure gelatin. By using the mixture design technique, the 14.73% gelatin, 0.2% Na2Ti3O7, and 85.07% DI water got the highest yield of tensile strength (1508.15 kP). This was an about 4.88% increase in the tensile strength property when compared with using TiO2.
Lactate-Loaded Nanoparticles Induce Glioma Cytotoxicity and Increase the Survival of Rats Bearing Malignant Glioma Brain Tumor

A glioblastoma is an aggressive form of a malignant glial-derived tumor with a poor prognosis despite multimodal therapy approaches. Lactate has a preponderant role in the tumor microenvironment, playing an immunoregulatory role as well as being a carbon source for tumor growth. Lactate homeostasis depends on the proper functioning of intracellular lactate regulation systems, such as transporters and enzymes involved in its synthesis and degradation, with evidence that an intracellular lactate overload generates metabolic stress on tumor cells and tumor cell death. We propose that the delivery of a lactate overload carried in nanoparticles, allowing the intracellular release of lactate, would compromise the survival of tumor cells. We synthesized and characterized silica and titania nanoparticles loaded with lactate to evaluate the cellular uptake, metabolic activity, pH modification, and cytotoxicity on C6 cells under normoxia and chemical hypoxia, and, finally, determined the survival of an orthotopic malignant glioma model after in situ administration. A dose-dependent reduction in metabolic activity of treated cells under normoxia was found, but not under hypoxia, independent of glucose concentration. Lactated-loaded silica nanoparticles were highly cytotoxic (58.1% of dead cells) and generated significant supernatant acidification. In vivo, lactate-loaded silica nanoparticles significantly increased the median survival time of malignant glioma-bearing rats (p = 0.005) when administered in situ. These findings indicate that lactate-loaded silica nanoparticles are cytotoxic on glioma cells in vitro and in vivo.
Global, Not Yet Local: Media Coverage of Climate Change and Environment Related Challenges in Latvia

Media are essential actors in transmitting, contesting and embedding the attitudes towards climate change, yet media performance in post-communist countries has been relatively little researched. Informed by conceptual frameworks of strategic narratives, agenda-setting and framing, this paper investigates the media coverage of climate change and environment related issues in Latvia. The paper demonstrates the representation of climate change and environment related issues in Latvian and Russian-speaking traditional and online media, using quantitative data analysis of 3753 media articles, video and audio broadcasts from August 2020 till January 2021, as well as qualitative content analysis of seven peaks. The findings reveal a significant amount of climate change and environment related articles and broadcasts in Latvian media. News agencies and public broadcasters are the most important media segments in terms of publishing, whereas online media are prior in terms of the audiences reached. International efforts emerge as a dominant theme in the media coverage, while climate change per se receives a minor journalist attention. Both observations confirm a low level of climate change domestication in the Latvian media. Media reliance on political and government information sources and prepackaged material suggests a high potential for official political narratives to spread, yet the persuasive power of strategic narratives remains blurred as the perception side is highly underreported.
Formation and Expansion of Memory B Cells against Coronavirus in Acutely Infected COVID-19 Individuals

Infection with the β-coronavirus SARS-CoV-2 typically generates strong virus-specific antibody production. Antibody responses against novel features of SARS-CoV-2 proteins require naïve B cell activation, but there is a growing appreciation that conserved regions are recognized by pre-existing memory B cells (MBCs) generated by endemic coronaviruses. The current study investigated the role of pre-existing cross-reactive coronavirus memory in the antibody response to the viral spike (S) and nucleocapsid (N) proteins following SARS-CoV-2 infection. The breadth of reactivity of circulating antibodies, plasmablasts, and MBCs was analyzed. Acutely infected subjects generated strong IgG responses to the S protein, including the novel receptor binding domain, the conserved S2 region, and to the N protein. The response included reactivity to the S of endemic β-coronaviruses and, interestingly, to the N of an endemic α-coronavirus. Both mild and severe infection expanded IgG MBC populations reactive to the S of SARS-CoV-2 and endemic β-coronaviruses. Avidity of S-reactive IgG antibodies and MBCs increased after infection. Overall, findings indicate that the response to the S and N of SARS-CoV-2 involves pre-existing MBC activation and adaptation to novel features of the proteins, along with the potential of imprinting to shape the response to SARS-CoV-2 infection.
Knowledge, Awareness, and Prevention of Norovirus Infection among Kindergarten Parents in Chengdu, China

Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis among children in China. However, little is known about parents’ knowledge of HuNoV infection and their understanding of how to prevent and control the disease. Therefore, we performed an exploratory survey to assess the level of knowledge of HuNoV infection among kindergarten parents. A cross-sectional survey was conducted by investigating kindergarteners’ parents through an online self-administered questionnaire between October 2020 and November 2020 in Chengdu, China. A total of 771 questionnaires were received with valid responses, and 81.97% of respondents had heard about NoV before. Among parents who had heard about HuNoV before, they had a poor awareness of incubation period, duration, and high-incidence seasons of HuNoV infection. The respondents also had a low-level awareness of how to clean the places contaminated by vomitus or stool. The multiple-regression analysis confirmed that factors associated with good knowledge regarding HuNoV infection were level of education, occupation, history of infection, and HuNoV learning experience. The most expected approach to learn about HuNoV among parents was the internet, followed by knowledge training in kindergartens, community information, and television. This is the first study to assess kindergarten parents’ knowledge and awareness of HuNoV infection. The survey results provide insights that would help in developing effective strategies and educational materials to prevent and control the disease.
Diversity and Source of Airborne Microbial Communities at Differential Polluted Sites of Rome

Biogenic fraction of airborne PM10 which includes bacteria, viruses, fungi and pollens, has been proposed as one of the potential causes of the PM10 toxicity. The present study aimed to provide a comprehensive understanding of the microbial community variations associated to PM10, and their main local sources in the surrounding environment in three urban sites of Rome, characterized by differential pollution rate: green area, residential area and polluted area close to the traffic roads. We combined high-throughput amplicon sequencing of the bacterial 16S rRNA gene and the fungal internal transcribed spacer (ITS) region, with detailed chemical analysis of particulate matter sampled from air, paved road surfaces and leaf surfaces of Quercus ilex. Our results demonstrated that bacterial and fungal airborne communities were characterized by the highest alpha-diversity and grouped separately from epiphytic and road dust communities. The reconstruction of source-sink relationships revealed that the resuspension/deposition of road dust from traffic might contribute to the maximum magnitude of microbial exchanges. The relative abundance of extremotolerant microbes was found to be enhanced in epiphytic communities and was associated to a progressively increase of pollution levels as well as opportunistic human pathogenicity in fungal communities.
Assessing Students‟ Approaches and Perceptions to Learning in Physics Experiments Based on Simulations and At-Home Lab Kits

Our study evaluates students‟ approaches to and perceptions of the use of hands-on at-home laboratory kits (HALK) experiments, open-source computer-based simulations (OSCBS), and their combination (OSCBS-HALK) in undergraduate introductory asynchronous online physics courses. Anonymous survey data from students who had completed online physics courses with labs based on simulations, at-home lab kits, or both were collected using a modified version of the Learn Questionnaire (MVLQ). Findings in this study indicate that among the six scales (interest and relevance; peer support; staff enthusiasm and support; teaching for understanding; alignment; and constructive feedback) used to measure students‟ perceptions of the teaching and learning environments, interest and relevance, peer support, and teaching for understanding had statistically significant different means across the three lab types. Post-hoc comparisons using the Tukey HSD test for the interest and relevance scale indicated that students viewed using a combination approach of OSCBS and HALK labs (M = 3.98, SD = 0.61) more significantly positive than using computer-simulated labs only (M = 3.56, SD = 0.75). Compared to other labs, computer-simulated labs were perceived to lead to a deep approach to learning. However, they had the lowest interest and relevance, peer support, and alignment ranking among the three lab groups. Thus, developing strategies to improve students‟ engagement and ability to translate the simulations into physical processes is recommended for OSCBS.
Exploring the Evolution and Determinants of Open Innovation: A Perspective from Patent Citations

The research of open innovation (OI) has developed considerably in recent years. In this article, a new perspective based on the patent citation network is provided to explore the dynamic evolution and mode of OI. In our framework of the OI network, enterprises are represented as nodes, and patent citations represent cross-organizational knowledge flow, which are ties in the network. The Driver Assistance System (DAS) was selected as the research case. Time-sliced patent citation networks are constructed, and then an exponential random graph model is employed to identify the formation mechanism of OI networks. The results show that the OI network of DAS is still partially open and at a low level. The inherent dominance of automakers may have been weakened, and new models and relationships in innovation activities are developing. In addition, heterogeneity in type and geographic proximity which significantly promote the formation of the open network was prevented, but the larger scale of the enterprise inhibited the OI network. R&D investment has no obvious impact. This research provides a new perspective to observe open innovation and helps stakeholders to better understand industry trends.
Combination of CLEC4M rs868875 G-Carriership and ABO O Genotypes May Predict Faster Decay of FVIII Infused in Hemophilia A Patients

The C-type lectin CLEC4M binds and internalizes factor VIII (FVIII). Common CLEC4M variants have been associated with FVIII pharmacokinetic (PK) profiles in hemophilia A (HA) patients. The two-compartment PK analysis of plasma-derived (pd-) and full length recombinant FVIII concentrates was conducted in twenty-six patients (FVIII:C ≤ 2 IU/dL). F8, ABO blood-groups, and the CLEC4M rs868875A/G polymorphism were genotyped. CLEC4M genotype groups differed for the elimination rate constant K 1-0 (p < 0.001), half-life (K 1-0 HL), and the Beta rate constant. Patients treated with pd-FVIII also differed in the Alpha phase. In linear regression models, the contribution of the CLEC4M genotypes to FVIII PK parameters remained significant after correction for ABO, age, and VWF antigen levels at PK. Combined CLEC4M rs868875A/G and ABO genotypes displayed significant interaction (K 1-0, p = 0.014). Compared to other combined genotypes, the G-carriers/O genotypes showed half-reduced K 1-0 HL (p = 0.008), and faster FVIII clearance (mean 7.1 ± 2.2 mL/h/kg SE) than in the G-carriers/non-O (mean 2.4 ± 0.3 mL/h/kg SE), (p = 0.038). Comparison in HA patients recruited in several countries suggests that CLEC4M genotypes coherently influence infused FVIII half-life and clearance. Our analysis supports substantially faster FVIII decay associated with the rs868875 G-carrier/ABO O genotypes, which has potential implications for genetically tailored substitutive HA treatment.
Localized Proteasomal Degradation: From the Nucleus to Cell Periphery

The proteasome is responsible for selective degradation of most cellular proteins. Abundantly present in the cell, proteasomes not only diffuse in the cytoplasm and the nucleus but also associate with the chromatin, cytoskeleton, various membranes and membraneless organelles/condensates. How and why the proteasome gets to these specific subcellular compartments remains poorly understood, although increasing evidence supports the hypothesis that intracellular localization may have profound impacts on the activity, substrate accessibility and stability/integrity of the proteasome. In this short review, I summarize recent advances on the functions, regulations and targeting mechanisms of proteasomes, especially those localized to the nuclear condensates and membrane structures of the cell, and I discuss the biological significance thereof in mediating compartmentalized protein degradation.
SA Anno 1995

In providing reflections on 25 years of situation awareness (SA) research, particularly the ever-popular 1995 model of SA, our response is twofold. First, we ask whether the model’s grasp has exceeded its epistemological reach. By overlooking important insights from the second cognitive revolution as well as from other late-20th-century developments in (social) science, it might well do that. In fact, SA, in its 1995 model, is strongly committed to a 17th-century ontology that separates mind from matter and sees awareness as a correspondence or mirror of the world outside. This view seems to strongly reverberate today in a somewhat dogmatic stance of the 1995 model about the role that the world and cognitive artifacts play in constituting cognitive processes. Second, we suggest that after 25 years of SA, we might need to reflect on what SA as a scientific human factors object has brought us or the operators we once set out to support. This is not a trivial or academic question. We know of one operator who is in jail today because the prosecution was able to successfully argue for the dereliction of his duty to maintain SA. Without the human factors community supplying this object, he might still be in jail, but surely not under this charge.
Atmospheric Drivers of Oceanic North Swells in the Eastern Caribbean

Large wintertime ocean swells in the Caribbean, known as north swells, generate high surf and expose communities, ecosystems, and infrastructure to hazardous conditions. Empirical orthogonal functions and cluster analyses using ERA5 reanalysis swell data are performed to characterize north swells in the eastern Caribbean and to establish a ranked list of historical events. ERA5 atmospheric and swell data are used to create basin-scale sea-level pressure, surface wind and swell composites for north swell events of different magnitudes. Additionally, storm events are identified in the mid-latitude North Atlantic Ocean. North swells are predominantly generated by storms that intensify off the North American east coast. However, there is a subset of moderately sized swells associated with a westward-located high-pressure system in the North Atlantic. While lower sea-level pressure and stronger surface winds are important for generating larger swells, the location of the low-pressure center and storm track as well the zonal speed of the storm are critical in the development of large eastern Caribbean north swells. The largest such events are associated with storms located comparatively further southeast, with a more zonal trajectory, and slower zonal speed. Large storms located further northwest, with a more southwest to northeast trajectory, and faster zonal speeds are associated with weaker north swells or in many cases, no significant north swell in the eastern Caribbean.
ANALYSIS OF MATHEMATICAL REPRESENTATION ABILITY ON ASSEMBLAGE MATERIAL FOR JUNIOR HIGH SCHOOL STUDENTS

This study aims to provide description of mathematical representation ability of Pekanbaru Junior High School students based on the answers to assemblage questions. The research method Decriptive method in the form of a survey was used in this research. The research subject are 25 students of class VII. The object of research is the ability of students' mathematical representation on the assemblage material. The data analysis technique uses deductive methods by collecting data, processing data, presenting data and also analyzing data with the help of experts and theories from a literature review. Data was collected by measuring written tests about mathematical representation abilities. Consists of 6 assemblage of essay questions with moderate criteria. Through the validity test, valid results were obtained with moderate and high criteria and had moderately correlated reliability with good criteria. The results of the data test and analysis concluded that students' mathematical representation abilities applied to assemblage material had 91% visual representation skills using diagrams, 76% representation skills using mathematical expressions, and 51% mathematical representation skills using words.
A Comprehensive Evaluation of Salt Tolerance in Tomato (Var. Ailsa Craig): Responses of Physiological and Transcriptional Changes in RBOH’s and ABA Biosynthesis and Signalling Genes

Salinity is a ubiquitous stressor, depleting osmotic potential and affecting the tomato seedlings’ development and productivity. Considering this critical concern, we explored the salinity response in tomato seedlings by evaluating them under progressive salt stress duration (0, 3, 6, and 12 days). Intriguingly, besides the adverse effect of salt stress on tomato growth the findings exhibited a significant role of tomato antioxidative system, RBOH genes, ABA biosynthesis, and signaling transcription factor for establishing tolerance to salinity stress. For instance, the activities of enzymatic and non-enzymatic antioxidants continued to incline positively with the increased levels of reactive oxygen species (O2•−, H2O2), MDA, and cellular damage, suggesting the scavenging capacity of tomato seedlings against salt stress. Notably, the RBOH transcription factors activated the hydrogen peroxide-mediated signalling pathway that induced the detoxification mechanisms in tomato seedlings. Consequently, the increased gene expression of antioxidant enzymes and the corresponding ratio of non-enzymatic antioxidants AsA-GSH suggested the modulation of antioxidants to survive the salt-induced oxidative stress. In addition, the endogenous ABA level was enhanced under salinity stress, indicating higher ABA biosynthesis and signalling gene expression. Subsequently, the upregulated transcript abundance of ABA biosynthesis and signalling-related genes suggested the ABA-mediated capacity of tomato seedlings to regulate homeostasis under salt stress. The current findings have revealed fascinating responses of the tomato to survive the salt stress periods, in order to improve the abiotic stress tolerance in tomato.
Interventional Radiology’s Osteoid Osteoma Management: Percutaneous Thermal Ablation

Osteoid osteoma (OO) is one of the most common benign bone tumors with specific clinical and radiological characteristics. Analgesic therapy and surgical treatment have been considered the only therapy for a long time. Recently, safe and effective new therapeutic options have been introduced, among which percutaneous thermal ablation techniques. This review aims to describe the recent updates in the field of percutaneous thermal ablation techniques in the treatment of OO, assessing the outcomes in terms of efficacy, complications, and recurrence rate.
Impact of the COVID-19 Pandemic on Colorectal and Prostate Cancer Screening in a Large U.S. Health System

During the first year of the coronavirus disease 2019 (COVID-19) pandemic, prevention measures included quarantining and facility closures. Because cancer screening is dependent on interventions in facilities, the extent of the COVID-19 impact on screening was questioned. A claims registry from a large health system was queried for colorectal and prostate cancer screening. A screening gap and screening loss ratio were calculated by comparing 2020 screening to historical reference years. All cancer screenings decreased in the first four months of the pandemic. Colorectal cancer screening returned to baseline in the latter six months of 2020. Prostate cancer screening exceeded baseline in the latter six months, but with a lesser gain than previous years. Populations disproportionately affected by decreased cancer screening included men and black people. To catch-up after the initial deficit in screening, it is estimated that the rate of colorectal cancer screening needs to increase by 50%.