Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence and prognostic factor in patients with good therapeutic response in a cohort of 172 patients with the homoeopathic medicine Aranea diadema: A multicentre, open-label, observational study

Aim: To assess the prevalence and prognostic factor of Aranea diadema in a population responding well to Aranea diadema. Material and Methods: It was an open label, multicentric observational study wherein patients having minimum two known symptoms matching with the pathogenesis of Aranea diadema were prescribed the remedy in 6C, 30C, 200C, and 1M potencies. The collected data were presented in terms of descriptive statistics. Results: A total of 6806 cases were enrolled. Out of which a total of 172 cases were analysed, and demographic analysis shows male/female: 109/63; mean age 28.3 years. There were “clinical successes” in 115 cases (67.0%) and no response in 57 (33.1%) cases. The number of symptoms found prevalent in responders included proving (n = 13) and literature (n = 8). Symptoms coming from provings guide homoeopathic practitioners in prescribing their medicines, but should also be confirmed in patients responding well to these medicines. Significantly higher prevalence was observed among responders in respect of six tentatively confirmed symptoms (prevalence): Forgetfulness (0.11), white coated tongue (0.21), epistaxis (0.10), thirstlessness (0.13), seminal emissions (0. 23), and fever (0.12). Conclusion: This study was conducted to assess the prevalence of symptoms in a population responding well to Aranea diadema and to compare this with the prevalence of these symptoms in other populations. If a symptom has a higher prevalence in a population responding well to Aranea it indicates the increase of likelihood of a curative action of Aranea when that symptom is present. Our “test”is not meant to diagnose an illness but to increase the accuracy of prescribing Aranea diadema.
Coronary artery disease in young versus older adults..

ackground: Coronary artery disease, is a major cause of mortality and morbidity worldwide . It's incidence among young age groups is increasing rapidly. Objectives: Coronary artery disease is now frequently encountered in young adult population. However, not many studies are available in this regard. Therefore, the present study was designed to evaluate the prevalence, clinical characteristics and angiographic features of patients ≤40 years of age with Coronary artery disease and compare them to patients >40 years. Methods: this study was conducted at shaheed al muhrab cardiac center in Hilla city, all patients who had underwent coronary angiography in the catheterization laboratory were included in the study during the period april 2008 to July 2011. Patient who had history of revascularization procedure were excluded from the study. The patients were divided into two groups on the basis of age. The first group (group A) include patients 40 years and younger, while the second group (group B) include patients older than 40 years. Results: of the total 803 patients , 58(7.2%) were ≤40 years old (group A) and 745 (92.8%) were older than 40 years (group B). Smoking , premature CAD and hyperlipidemia were statically significant risk factors in patients≤40 years old (group A) 24.2%,19% ,17.2% respectively compared to 13.2%,10.3%, 10.7% in patients older than 40 years (group B), whereas hypertension, diabetes mellitus and obesity were more prevalent in(Group B), 27%,22.8%, 16% respectively, compared to (Group A) , 15.5%,13.8%, 10.3% respectively (p<0.001) . 7.2% of patient who have evidence of CAD proved by coronary angiography were in age group ≤40 years. Younger patients (group A) tends to have single vessel disease 56.9% compared to older patients (group B) 24.4%, and the reverse is true in regards to three vessel disease 44.2% vs19%. Conclusions: 7.2% of angiographically documented cases of coronary artery disease patients were 40 years & younger in age, this percentage was high among our studied population. Smoking, family history of premature Coronary artery disease & hyperlipidemia were significantly associated with Coronary artery disease in young patients (p<0.001) Young patients tends to have single vessel disease while older ones tends to have three vessel disease (p<0.001).
Algorithmic Knowledge Gaps: A New Dimension of (Digital) Inequality

Algorithms serve as gatekeepers and arbiters of truth online. Understanding how algorithms influence which information individuals encounter better enables them to properly calibrate their reception of the information. Yet, knowledge of platform algorithms appears to be limited and not universally distributed. In line with the long history of knowledge inequities, we suggest that algorithmic knowledge varies according to socioeconomic advantage. We further argue that algorithms are experience technologies in that they are more easily understood through use. Nevertheless, socioeconomic background continues to shape information and communication technology use, thereby further influencing disparities in algorithmic knowledge. Using data from a survey of a random sample of Internet users in the United States, we found support for the relationship between algorithmic knowledge and socioeconomic background in the context of online search. The findings provide preliminary evidence that extant structural inequalities underlie algorithmic knowledge gaps in this domain
UNIVERSITY OF NAIROBI DEPARTMENT OF SOCIOLOGY AND SOCIAL WORK Household Factors Affecting the Implementation of Forest Conservation Strategies. A Case of South Nandi Forest, Nandi County, Kenya CHARLES KIPRONO KOECH

xiii CHAPTER ONE: INTRODUCTION . 1 1.1 Background of the study . 1 1.2 Statement of the Problem . 4 1.3 Research questions . 5 1.4 Objectives of the Study . 6 1.4. 1 Main Objective . 6 1.4. 2 Specific objectives of the study . 6 1.5 Significance of the Study . 6 1.6 Scope and limitation of the study . 7 CHAPTER TWO: LITERATURE REVIEW AND THEORITICAL FRAMEWORK . 8 2.0 Introduction . 8 2.1 Concept of Forest Conservation . 8 2.2 Literature Review . 9 2.2.1 Household Level of Income and Forest Conservation . 9 2.2.2 Community awareness and forest conservation . 12
Does Rapid Agricultural Growth Require a System of Innovation? Evidence from Ghana and Burkina Faso

This paper tests the 'systems of innovation' hypothesis for a selection of crops in Ghana and Burkina Faso that have shown significant growth in production over an approximately 20-year period. The question is whether such growth can only occur if supported by a system of innovation. Using two indicators (a common understanding on objectives and priorities, and a high level of interactivity) we find little evidence for the existence of anything that might be considered a high functioning system of innovation.
Outcomes of Hemodialysis Native Arteriovenous Fistula Creation in Iraq: A Combine Prospective and Retrospective Study

End stage renal disease (ESRD) is defined asan irrevesible decline in kidney function,when renal replacement therapy (RRT) is needed for survival [1]. Three modalities are present for treatment of ESRD: haemodialysis, peritoneal dialysis and renal trasplantation [2]. It is crucial to have a basic understanding of the dialysis vascular access (VA). A patient survival depends on proper functioning of this lifeline [3]. The vascular surgeon is frequently asked to provide a VA to ESRD patient for long term haemodialysis. The exposure of venous system of forearm to systemic arterial pressure results in the arterialization of veins. Being subcutaneously located; these veins can be punctured repeatedly at the time of H.D [4]. With modern dialysis techniques, the ESRD patient has many years of dialysis life ahead of him during which a successful renal transplant may represent only a dialysis free interval in his chronic renal failure history and hence the importance of suitable planning of VA surgery can be appreciated [5]. It is absolutely necessary to preserve the patency of upper limb veins [4,5]. VA surgery must be planned and conducted by a surgeon with an appropriate training and experience in this sphere [3-5].
Consumption and Tax Smoothing with Complete and Incomplete Markets

• One is in the complete markets tradition of Lucas and Stokey [4]. • The other is in the incomplete markets tradition of Hall [3] and Barro [1]. • Complete markets* allow a consumer or government to buy or sell claims contingent on all possible states of the world. • Incomplete markets* allow a consumer or government to buy or sell only a limited set of securities, often only a single risk-free security.
Evaluation of acute oral toxicity of ethanolic extract of (Roxb.) Terminalia tomentosa stem bark in Swiss albino mice

Folklore medicine still occupies a major role in the practice of rural medicine. According to a report published by World Health Organization, out of the total world's population, about 80% still relies on traditional medicine (Saleem et al., 2017). In developing countries like India, 65% of rural communities still uses the traditional form of medicine to fulfill their primary health care need (Vaidya and Devasagayam, 2007). However, in spite of being the lifeline of medical practice in developing countries, the issue of safety evaluation of these herbal medications are not given due importance owing to the general notion that herbal products have minimal side effects (Shankar et al., 2012). However, on the contrary, use of various herbal therapies has been reported to be associated with long-term side effects (Chen et al., 2006). Owing to the growing popularity of herbal products among the modern urban population too, the focus has now turned on elucidating the toxic potential of these herbal products so as to make their use more safe and effective.
University of Southern Denmark Hydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and γ-ENaC abundance in rat kidney Zachar,

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COMBINING MIGRATION DATA IN ENGLAND AND WALES

The study of migration is hindered by data availability and data quality. Overcoming data issues is a central problem in migration research. Surveys are usually not big enough to capture migration movements, as most people remain in a particular locality within a given time period. In other cases, data are inadequate because of non-response or of data suppression for confidentiality reasons. This is particularly relevant for analyses at relatively high levels of spatial disaggregation. Also, inconsistencies arise due to different migrant definitions caused by various migrant data collection systems (e.g., surveys, censuses or population registers). Finally, detailed migration data at high levels of spatial disaggregation are generally only available from censuses, which only occur every five or ten years and are often outdated by the time they come out. In England and Wales, there are two main sources of internal migration data. Annual flows of migration by origin, destination, age and sex can be obtained from the National Health Service registers. More detailed data can be obtained from the decennial censuses. Our research will develop methodologies to combine these two sources of information for the purpose of producing reliable and detailed estimates of migration. Methods for combining a third data source, such as survey information will also be explored. The outcome will consist of three time series of detailed estimates of internal migration cross-classified by five variables: origin, destination, age and sex, and ethnicity, education or employment. These estimates can then be used to improve our understanding of migration behaviour or even the forecasting of future migration flows.
Clinico-histopahological patterns of benign gynecological lesions at a tertiary hospital in Eastern Nigeria: a 5 year review

Gynecological lesions have a wide range of clinical features and are a source of physical and/or psychological distress to affected women with socioeconomic implications for the larger society. Many benign gynecological lesions are associated with significant morbidity; endometriosis producing chronic pelvic pain and infertility is just one example. In these cases need for a thorough history, physical examination and laboratory evaluation cannot be overemphasized; given the fact that certain conditions will have atypical presentation. The clinical features of each disorder are made clearer with a concise history and a comprehensive physical examination. This enables the clinician decide on the relevant investigations to undertake; this is crucial especially in resource constrained settings coupled with the burden of HIV/AIDS in sub-Saharan Africa.
A Survey on the readiness of e-teaching among Faculty Members of Zanjan University of Medical Sciences in 2014

Background: Application of technology for education accounts for an important aspect of expansion of the information technology in the present century. Objectives: This study aims to examine the degree of readiness of the faculty member of Zanjan University of Medical Sciences for e-Teaching. Methods: This descriptive-cross-sectional study focused on the degree of readiness of 70 faculty member of Zanjan University of Medical Sciences in 2014. It followed the simple randomized sampling method. The readiness of faculty member was assessed from five dimensions, including organizational support, perceived value, and time commitment, working skill, access to computer, internet and attitude towards e-Teaching, using a standard questionnaire. The data were analyzed using descriptive statistics indices, Pearson correlation coefficient and Logistic Regression Model at 95% confidence interval. Results: The university faculty member were in adequate level of readiness in terms of organizational support (46.4%), positive attitude towards e-Teaching (49.3%); the skill of work with computer (49.3%), time commitment (44.9%), access to computer (49.3%) and positive perceived value (45.6%). The predictive variables of the university faculty member’ readiness were appropriate in terms of organizational support, access to computer and in term of, perceived value, age and gender of the university faculty member in term of, perceived time obligation, skill in work with computer and organizational support. Conclusion: The results showed that readiness of the the faculty member of Zanjan University of Medical Sciences for e-Teaching was in a relatively appropriate level. Expanson of the technological infrastructure, holding empowerment workshops in order for improvement of the required skill and changing attitude of the university faculty member for e-Teaching are suggested.
Prevalence of androgen receptors expression in triple negative breast cancer patients and its correlation with clinicopathological criteria: Our institutes experience.

e12584Background: Triple negative breast cancer (TNBC) is a term that has been applied to breast cancers which lack expression of three receptors: estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2). It represents about 20% of breast cancers diagnosed worldwide. TNBC is a challenging type by its presentation criteria and limited options of treatment. Continuous research for finding specific target is the aim of scientists. Androgen receptors (AR) expression take special attention in this type of breast cancer as its expression can help for finding special targeted treatment as antiandrogen therapy.Purpose:is to assess the AR expression in TNBC patients and to correlate its expression with clinicopathological parameters and disease outcome of patients in study populations. Methods: This prospective study included 90 female patients confirmed as TNBC patients in medical oncology and clinical oncology departments, in Mansoura University and Zagazig Univ.
Human olfactory mesenchymal stromal cells co-expressing horizontal basal and ensheathing cell proteins in culture

Abstract Introduction: The olfactory neuro-epithelium has an intrinsic capability of renewal during lifetime provided by the existence of globose and horizontal olfactory precursor cells. Additionally, mesenchymal stromal olfactory cells also support the homeostasis of the olfactory mucosa cell population. Under in vitro culture conditions with Dulbecco modified eagle/F12 medium supplemented with 10% fetal bovine serum, tissue biopsies from upper turbinate have generated an adherent population of cells expressing mainly mesenchymal stromal phenotypic markers. A closer examination of these cells has also found co-expression of olfactory precursors and ensheathing cell phenotypic markers. These results were suggestive of a unique property of olfactory mesenchymal stromal cells as potentially olfactory progenitor cells. Objective: To study whether the expression of these proteins in mesenchymal stromal cells is modulated upon neuronal differentiation. Materials and methods: We observed the phenotype of olfactory stromal cells under DMEM/F12 plus 10% fetal bovine serum in comparison to cells from spheres induced by serum-free medium plus growth factors inducers of neural progenitors. Results: The expression of mesenchymal stromal (CD29+, CD73+, CD90+, CD45-), horizontal basal (ICAM-1/CD54+, p63+, p75NGFr+), and ensheathing progenitor cell (nestin+, GFAP+) proteins was determined in the cultured population by flow cytometry. The determination of Oct 3/4, Sox-2, and Mash-1 transcription factors, as well as the neurotrophins BDNF, NT3, and NT4 by RT-PCR in cells, was indicative of functional heterogeneity of the olfactory mucosa tissue sample. Conclusions: Mesenchymal and olfactory precursor proteins were downregulated by serum-free medium and promoted differentiation of mesenchymal stromal cells into neurons and astroglial cells.
Prospective Feasibility Study for Using Cell-Free Circulating Tumor DNA–Guided Therapy in Refractory Metastatic Solid Cancers: An Interim Analysis

Purpose Retrospective studies have demonstrated that cell-free circulating tumor DNA (ctDNA) hotspot testing predicts matched therapy response to first- and second-line therapies in patients with advanced non–small-cell lung cancer (NSCLC). However, no prospective outcomes studies have evaluated ctDNA-guided matched therapy decision making on the basis of comprehensive plasma genomic testing including all four major classes of alterations. Here, we report the clinical utility of this approach in advanced solid tumor cancers. Patients and Methods We conducted a multiple parallel cohort, open-label, clinical trial using ctDNA-guided matched therapy when tissue was insufficient or unobtainable for next-generation sequencing. Plasma-based digital sequencing identified point mutations in 70 genes and indels, fusions, and copy number amplifications in selected genes. Patients with prespecified targetable alterations in metastatic NSCLC, gastric cancer (GC), and other cancers were matched to several independent targeted agent trials at a tertiary academic center. Results Somatic alterations were detected in 59 patients with GC (78%), and 25 patients (33%) had targetable alterations (ERBB2, n = 11; MET, n = 5; FGFR2, n = 3; PIK3CA, n = 6). In NSCLC, 62 patients (85%) had somatic alterations, and 34 (47%) had targetable alterations (EGFR, n = 29; ALK, n = 2; RET, n = 1; ERBB2, n = 2). After confirmation of ctDNA findings on tissue (to meet trial eligibility criteria), 10 patients with GC and 17 patients with NSCLC received molecularly matched therapy. Response rate and disease control rate were 67% and 100%, respectively, in GC and 87% and 100%, respectively, in NSCLC. Response was independent of targeted alteration variant allele fraction in NSCLC (P = .63). Conclusion To our knowledge, this is the first prospective feasibility study of comprehensive ctDNA-guided treatment in advanced GC and lung cancers. Response rates in this interim analysis are similar to those in tissue-based targeted therapy studies.
Application of Molecular Dynamics in Coating Ag-Conjugated Nanoparticles with Potential Therapeutic Applications

Drug delivery systems may benefit from nanoparticles synthesized using biological methods. While chemical reduction of particles is facilitated by some active compounds present in the bio-extract, other active compounds, with potential therapeutic activities, may be adsorbed onto the surface of nanoparticles. However, the mechanism of bio-based nanoparticle synthesis is still under debate. Here, we first employed a molecular dynamics (MD) approach to theoretically predict the coating of a hypothetical 4.5 nm silver nanoparticle with four selected rosemary (Rosmarinus Officinalis L.) active compounds (rosmanol, isorosmanol, carnosol, and carnosic acid). Analysis of density maps and radial distribution functions (RDF) values suggested that the examined compounds had strong hydrophobic properties and could instantaneously be adsorbed to the nanoparticle surfaces. Next, we experimentally examined the capacity of rosemary leaf extract to synthesize and coat Ag-conjugated nanoparticles. The data obtained from ultraviolet–visible spectroscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy and X-ray powder diffraction analyses confirmed the production of spherical Ag-conjugated nanoparticles with an average size of 12-15 nm, coated with proteins, secondary metabolites and other active compounds. Since this method can predict the dynamic behavior of therapeutic compounds when they are in contact with nanoparticles, we believe it provides a valid and new avenue to designing new therapeutic nanoparticles.
Electronic word-of-mouth as a Tool for Branding Sunset Restaurants

This paper aims to investigate the effect of electronic-word-of-mouth (e-WOM) on brand awareness and equity for the emerging segment of sunset restaurants. By applying the method of user-generated content analysis the current research examines the impact of reviews posted on TripAdvisor regarding sunset restaurants in Thailand. The findings of the study indicate that certain contextual elements along with content characteristics enhanced the brand relationships between the travelers and dining establishments. The meta-commentary interpretation of the online content reveals that recommendation reciprocity and review consensus stimulate the affinity among the users while increasing the visitor empathy for particular restaurants.