Miracle-dz/UniFAR-FTUs huggingface dataset:
Stanniocalcin-1 in the female reproductive system and pregnancy

Abstract BACKGROUND Stanniocalcin-1 (STC-1) is a widely expressed glycoprotein hormone involved in a diverse spectrum of physiological and pathophysiological processes including angiogenesis, mineral homeostasis, cell proliferation, inflammation and apoptosis. Over the last 20 years, numerous studies have reported STC-1 expression within female reproductive tissues including the uterus, ovaries and placenta and implicated STC-1 in processes such as ovarian follicular development, blastocyst implantation, vascular remodelling in early pregnancy and placental development. Notably, dysregulation of STC-1 within reproductive tissues has been linked to the onset of severe reproductive disorders including endometriosis, polycystic ovary syndrome, poor trophoblast invasion and placental perfusion in early pregnancy. Furthermore, significant changes in tissue expression and in maternal systemic concentration take place throughout pregnancy and further substantiate the vital role of this protein in reproductive health and disease. OBJECTIVE AND RATIONALE Our aim is to provide a comprehensive overview of the existing literature, to summarise the expression profile and roles of STC-1 within the female reproductive system and its associated pathologies. We highlight the gaps in the current knowledge and suggest potential avenues for future research. SEARCH METHODS Relevant studies were identified through searching the PubMed database using the following search terms: ‘stanniocalcin-1’, ‘placenta’, ‘ovary’, ‘endometrium’, ‘pregnancy’, ‘reproduction’, ‘early gestation’. Only English language papers published between 1995 and 2020 were included. OUTCOMES This review provides compelling evidence of the vital function that STC-1 plays within the female reproductive system. The literature presented summarise the wide expression profile of STC-1 within female reproductive organs, as well as highlighting the putative roles of STC-1 in various functions in the reproductive system. Moreover, the observed link between altered STC-1 expression and the onset of various reproductive pathologies is presented, including those in pregnancy whose aetiology occurs in the first trimester. This summary emphasises the requirement for further studies on the mechanisms underlying the regulation of STC-1 expression and function. WIDER IMPLICATIONS STC-1 is a pleiotropic hormone involved in the regulation of a number of important biological functions needed to maintain female reproductive health. There is also growing evidence that dysregulation of STC-1 is implicated in common reproductive and obstetric disorders. Greater understanding of the physiology and biochemistry of STC-1 within the field may therefore identify possible targets for therapeutic intervention and/or diagnosis.
History of previous surgery is associated with higher risk of revision after primary total knee arthroplasty: a cohort study from the Geneva Arthroplasty Registry

Background and purpose — Prior to primary total knee arthroplasty (pTKA), 6–34% of patients have undergone surgical procedure(s) of their knee. We investigated whether history of previous surgeries influences the risk of revision of pTKA, the risk according to the type of previous surgery, and how previous surgery influences specific causes of revision and the time of revision. Patients and methods — This is a prospective cohort study from the Geneva Arthroplasty Registry. All pTKA between 2000 and 2016 were included and followed until December 31, 2019. Outcomes were risk of revision, evaluated using Kaplan–Meier survival and Cox and competing risks regression, the specific causes, and time of revision. Results — Of 3,945 pTKA included (mean age 71 years, 68% women), 21% had a history of previous surgery, with 8.3% revisions vs. 4.3%, at 3–20 years’ follow-up (mean 8.6). 5- and 10-year cumulative failure by previous surgery (yes vs. no) were 6.6% (95% CI 5.1–8.5) vs. 3.3% (CI 2.7–4.0), and 8.4% (CI 6.6–10.6) vs. 4.5% (CI 3.8–5.4). Baseline differences explained only part of the higher risk (adjusted HR 1.5, CI 1.1–2.1). The risk of failure was higher for all causes of revision considered. Patients in the previous surgery group had a higher risk of an early revision. Interpretation — A history of previous surgery adversely affected the outcome with a 1.5 times higher cumulative risk of all-cause revision over the course of up to 20 years after index surgery. The increased risk was seen for all causes of revision and was highest in the first years.
Rostral neurovasculature indicates sensory trade‐offs in Mesozoic pelagic crocodylomorphs

Metriorhynchoid thalattosuchians were a marine clade of Mesozoic crocodylomorphs that evolved from semi‐aquatic, “gharial”‐like species into the obligately pelagic subclade Metriorhynchidae. To explore whether the sensory and physiological demands of underwater life necessitates a shift in rostral anatomy, both in neurology and vasculature, we investigate the trigeminal innervation and potential somatosensory abilities of metriorhynchoids by digitally segmenting the rostral neurovascular canals in CT scans of 10 extant and extinct crocodyliforms. The dataset includes the terrestrial, basal crocodyliform Protosuchus haughtoni, two semi‐aquatic basal metriorhynchoids, four pelagic metriorhynchids and three extant, semi‐aquatic crocodylians. In the crocodylian and basal metriorhynchoid taxa, we find three main neurovascular channels running parallel to one another posteroanteriorly down the length of the snout, whereas in metriorhynchids there are two, and in P. haughtoni only one. Crocodylians appear to be unique in their extensive trigeminal innervation, which is used to supply the integumentary sensory organs (ISOs) involved with their facial somatosensory abilities. Crocodylians have a far higher number of foramina on the maxillary bones than either metriorhynchoids or P. haughtoni, suggesting that the fossil taxa lacked the somatosensory abilities seen in extant species. We posit that the lack of ISO osteological correlates in metriorhynchoids is due to their basal position in Crocodyliformes, rather than a pelagic adaptation. This is reinforced by the hypothesis that extant crocodyliforms, and possibly some neosuchian clades, underwent a long “nocturnal bottleneck”—hinting that their complex network of ISOs evolved in Neosuchia, as a sensory trade‐off to compensate for poorer eyesight.
Web-based system for face mask detection and face recognition

Even though people are now getting vaccinated, it might still take time for things to come back to normal. Until then, wearing masks and social distancing is the most-effective preventive measure against the spread of COVID-19. This leads to the necessity of a system that will detect face masks in real-time video streams. Our solution detects whether a person is wearing a mask or not. If he/she is not wearing a mask then his/her photo would be captured and given as input to a face recognition system which will identify the person. The solution further provides the person’s information to the administrator and allows him to take any further action if needed. The above solution is implemented using neural networks to detect masks and the website is created using Google Flutter framework. [9] The ‘Web Based System for Face Mask Detection and Face Recognition’ can be used to ensure the safety of people by implementing it in large crowd gathering places like college campuses and offices.
Ionic Functionalization of Multivariate Covalent Organic Frameworks to Achieve Exceptionally High Iodine Capture Capacity.

Adsorption-based iodine (I 2 ) capture is of great potential for the treatment of radioactive nuclear waste. Here we employ a "multivariate" synthetic strategy to construct ionic covalent organic frameworks (iCOFs) with large surface area, high pore volume, and abundant binding sites for I 2 capture. The optimized material iCOF-AB-50 exhibits static I 2 uptake capacity of 10.21 g·g -1 at 75 °C, and dynamic uptake capacity of 2.79 g·g -1 at ~400 ppm of I 2 and 25 °C, far exceeding the performances of previously reported adsorbents under similar conditions. It also shows fast adsorption kinetics, good moisture tolerance, and full reusability. The promoting effect of ionic groups on I 2 adsorption has been elucidated by experimentally identifying the iodine species adsorbed at different sites and calculating their binding energies. This work demonstrates the essential role of balancing the textural properties and binding sites of the adsorbent in achieving high I 2 capture performance.
Awareness, treatment, and control of hypertension in adults aged 45 years and over and their spouses in India: A nationally representative cross-sectional study

Background Lack of nationwide evidence on awareness, treatment, and control (ATC) of hypertension among older adults in India impeded targeted management of this condition. We aimed to estimate rates of hypertension ATC in the older population and to assess differences in these rates across sociodemographic groups and states in India. Methods and findings We used a nationally representative survey of individuals aged 45 years and over and their spouses in all Indian states (except one) in 2017 to 2018. We identified hypertension by blood pressure (BP) measurement ≥140/90 mm Hg or self-reported diagnosis if also taking medication or observing salt/diet restriction to control BP. We distinguished those who (i) reported diagnosis (“aware”); (ii) reported taking medication or being under salt/diet restriction to control BP (“treated”); and (iii) had measured systolic BP <140 and diastolic BP <90 (“controlled”). We estimated age–sex adjusted hypertension prevalence and rates of ATC by consumption quintile, education, age, sex, urban–rural, caste, religion, marital status, living arrangement, employment status, health insurance, and state. We used concentration indices to measure socioeconomic inequalities and multivariable logistic regression to estimate fully adjusted differences in these outcomes. Study limitations included reliance on BP measurement on a single occasion, missing measurements of BP for some participants, and lack of data on nonadherence to medication. The 64,427 participants in the analysis sample had a median age of 57 years: 58% were female, and 70% were rural dwellers. We estimated hypertension prevalence to be 41.9% (95% CI 41.0 to 42.9). Among those with hypertension, we estimated that 54.4% (95% CI 53.1 to 55.7), 50.8% (95% CI 49.5 to 52.0), and 28.8% (95% CI 27.4 to 30.1) were aware, treated, and controlled, respectively. Across states, adjusted rates of ATC ranged from 27.5% (95% CI 22.2 to 32.8) to 75.9% (95% CI 70.8 to 81.1), from 23.8% (95% CI 17.6 to 30.1) to 74.9% (95% CI 69.8 to 79.9), and from 4.6% (95% CI 1.1 to 8.1) to 41.9% (95% CI 36.8 to 46.9), respectively. Age–sex adjusted rates were lower (p < 0.001) in poorer, less educated, and socially disadvantaged groups, as well as for males, rural residents, and the employed. Among individuals with hypertension, the richest fifth were 8.5 percentage points (pp) (95% CI 5.3 to 11.7; p < 0.001), 8.9 pp (95% CI 5.7 to 12.0; p < 0.001), and 7.1 pp (95% CI 4.2 to 10.1; p < 0.001) more likely to be aware, treated, and controlled, respectively, than the poorest fifth. Conclusions Hypertension prevalence was high, and ATC of the condition were low among older adults in India. Inequalities in these indicators pointed to opportunities to target hypertension management more effectively and equitably on socially disadvantaged groups.
PEX26 gene genotype-phenotype correlation in neonates with Zellweger syndrome

Background Zellweger syndrome (ZS) is commonly manifested as facial deformities, hypotonia, and liver dysfunction. However, ZS caused by PEX26 gene mutation shows a broad and dispersed clinical pattern. In this study, the PEX26 gene in ZS was analyzed to enrich its clinical characteristics. Meanwhile, phenotypic and genotypic characteristics of Zellweger spectrum disorder (ZSD) induced by PEX26 mutation were evaluated. Methods The clinical data of newborn with ZS in our hospital were analyzed retrospectively. We performed WES and found that the infant carried the PEX26 gene variant. We searched the biomedical literature databases (PubMed, Web of Science, and EMBASE) to compare clinical features and genotypes. Results The neonate developed facial deformities, hypotonia, feeding difficulties, and seizures. Her homozygous variant was found in the PEX26 gene (NM_017929: exon2: c.34del) inherited from both parents. Electronic databases, including our case, reported 32 pathogenic variants in PEX26. We found that variation c.292C> T accounted for the largest proportion of PEX26 mutations (16/66, 24.24%). The proportion of deleterious mutations in ZS patients was significantly higher than that in NALD and IRD patients. Conclusions We identified pathogenic variations in the PEX26 gene and expanded the known mutant spectrum. By comparing patients with PEX26 mutations, the study determined that a significantly higher percentage of deleterious mutations in ZS was associated with severe clinical phenotypic characteristics.
Adaptive Neural Event-Triggered Control of Networked Markov Jump Systems Under Hybrid Cyberattacks

This article is concerned with the neural network (NN)-based event-triggered control problem for discrete-time networked Markov jump systems with hybrid cyberattacks and unmeasured states. The event-triggered mechanism (ETM) is used to reduce the communication load, and a Luenberger observer is introduced to estimate the unmeasured states. Two kinds of cyberattacks, denial-of-service (DoS) attacks and deception attacks, are investigated due to the vulnerability of cyberlayer. For the sake of mitigating the impact of these two types of cyberattacks on system performance, the ETM under DoS jamming attacks is discussed first, and a new estimation of such mechanism is given. Then, the NN technique is applied to approximate the injected false information. Some sufficient conditions are derived to guarantee the boundedness of the closed-loop system, and the observer and controller gains are presented by solving a set of matrix inequalities. The effectiveness of the presented control method is demonstrated by a numerical example.
Evaluation of Racial and Ethnic Disparities in Cardiac Transplantation

Background Racial and ethnic disparities contribute to differences in access and outcomes for patients undergoing heart transplantation. We evaluated contemporary outcomes for heart transplantation stratified by race and ethnicity as well as the new 2018 allocation system. Methods and Results Adult heart recipients from 2011 to 2020 were identified in the United Network for Organ Sharing database and stratified into 3 groups: Black, Hispanic, and White. We analyzed recipient and donor characteristics, and outcomes. Among 32 353 patients (25% Black, 9% Hispanic, 66% White), Black and Hispanic patients were younger, more likely to be women and have diabetes mellitus or renal disease (all, P<0.05). Over the study period, the proportion of Black and Hispanic patients listed for transplant increased: 21.7% to 28.2% (P=0.003) and 7.7% to 9.0% (P=0.002), respectively. Compared with White patients, Black patients were less likely to undergo transplantation (adjusted hazard ratio [aHR], 0.87; CI, 0.84–0.90; P<0.001), but had a higher risk of post‐transplant death (aHR, 1.14; CI, 1.04–1.24; P=0.004). There were no differences in transplantation likelihood or post‐transplant mortality between Hispanic and White patients. Following the allocation system change, transplantation rates increased for all groups (P<0.05). However, Black patients still had a lower likelihood of transplantation than White patients (aHR, 0.90; CI, 0.79–0.99; P=0.024). Conclusions Although the proportion of Black and Hispanic patients listed for cardiac transplantation have increased, significant disparities remain. Compared with White patients, Black patients were less likely to be transplanted, even with the new allocation system, and had a higher risk of post‐transplantation death.
Association of hepatitis B virus infection status with outcomes of non-small cell lung cancer patients undergoing anti-PD-1/PD-L1 therapy

Background The aim of this study was to evaluate the safety and survival outcomes of anti-programmed cell death (PD)-1/programmed cell death-ligand 1 (PD-L1) monotherapy in patients with advanced non-small cell lung cancer (NSCLC) and different hepatitis B virus (HBV) infection status. Methods Patients with advanced NSCLC and both chronic and/or resolved HBV infection who were treated with anti-PD-(L)1 monotherapy were retrospectively enrolled. The primary endpoint was the safety of PD-1/PD-L1 monotherapy, while the secondary endpoints included the survival outcomes. Results Of the 62 eligible patients, 10 (16.1%) were hepatitis B surface antigen (HBsAg) positive [chronic hepatitis B (CHB) infection] and 52 (83.9%) were HBsAg negative and HBcAb positive [resolved hepatitis B (RHB) infection]; 42 (67.7%) patients had at least 1 treatment-related adverse event (AE), with 4 patients (6.5%) developing grade 3 AEs and 6 (9.7%) developing hepatic AEs. One CHB patient experienced HBV reactivation during anti-PD-1 immunotherapy due to the interruption of antiviral prophylaxis. The objective response rate and durable clinical benefit (DCB) rate were 17.7% and 29.0%, respectively. Median overall survival (OS) and progression-free survival (PFS) were 23.6 months [95% confidence interval (CI): 14.4–32.8] and 2.1 months (95% CI: 1.2–3.0), respectively. The DCB rate was significantly higher in the CHB group than in the RHB group (60% vs. 23.1%; P=0.048). Patients with CHB experienced a longer PFS (8.3 vs. 2.0 months; P=0.103) and OS (35.0 vs. 18.2 months, P=0.119) than did RHB patients. Conclusions Anti-PD-(L)1 monotherapy was safe and effective in patients with NSCLC and HBV infection. This population should not be excluded from receiving immunotherapy in routine clinical practice or within clinical trials if HBV biomarkers are monitored and antiviral prophylaxis is properly used.
Acarbose versus orlistat in weight management of infertile women with polycystic ovarian syndrome: a prospective randomized controlled trial

theories put forward to explain the metabolic abnormalities associated with obesity may explain the role of obesity in the development of PCOS. The adipokine theory suggests that the adipose tissue is an endocrine organ that secrets several hormones (adipokines). Alteration in adipokines levels may lead to the development of PCOS. 1 In 1935, obesity was recognized as a common feature of the PCOS by Stein and Leventhal. Environmental factors such as lifestyle contribute to development of obesity in PCOS. Obesity exacerbates reproductive and metabolic abnormalities such as type 2 diabetes, hypertension and coronary heart disease associated in PCOS. Women with having a body mass index (BMI) of >25 kg/m 2 are reported to be overweight or obese and comprises 40-80% of those with PCOS 2. The World Health Organization has declared obesity an epidemic. Fundamental treatment of obesity includes lifestyle intervention such as nutrition, physical activity and behavior therapy. However, effects of lifestyle intervention are not always satisfactory in all cases. Pharmacotherapy is used in many patients in conjunction with lifestyle intervention. Pharmacotherapy is indicated for individuals with a body mass index (BMI) >30 kg/m 2 and for overweight women with a body mass ABSTRACT Background: Polycystic Ovarian Syndrome (PCOS) affects about 4 to 12% of women worldwide. PCOS is the most common cause of anavulation in infertile women. The endocrine dysfunction of PCOS is aggravated by obesity. Weight management is the first line treatment of this condition. In this study, we tried to compare acarbose versus orlistat in weight management of infertile women with polycystic ovarian syndrome. The aim of this study was to compare the effects of acarbose and orlistat in weight management of infertile polycystic ovarian syndrome women. Methods: This open label randomized controlled trial study was conducted in the Department of Reproductive Endocrinology and Infertility, BSMMU, Dhaka, Bangladesh. The study period was 1 year from July 2019 to June 2020. A total of 32 obese infertile women with PCOS were included in the study and randomized to two treatment arms: acarbose 100 mg tds for 3 months and orlistat 120 mg tds for 3-months. Results: The response of adequate (>10%) weight reduction with acarbose was 67% of that with orlistat. The side effects with acarbose were 15% of that with orlistat. Acanthosis nigricans was reduced in 18.8% (n=3/16) of those receiving acarbose.Menstrual cycle regularized in 37.5% (n=6/16) in experimental (acarbose) group and in 18.8% (n=3/16) in control (orlistat) group. Conclusions: The therapeutic potential of acarbose in reducing weight was relatively less than orlistat in obese infertile PCOS women.
The effect of 26 versus 29-inch wheel diameter in the transmission of vibrations in cross-country mountain biking.

Vibrations experienced by cyclists can affect their performance and health. We analysed the vibrations transmitted by mountain bike (26 or 29-inch wheels), in a 2,110 m circuit with a sample of 55 cyclists. The results indicate that the 29"-wheel increases speed (p < 0.001) and thus performance but it also increases exposure to vibrations as the root mean square (RMS) indicate (p = 0.001). The wheel diameter significantly affected the accelerometer-related dependent variables (p < 0.01), specifically seen in the RMS variable (p < 0.01). Regarding vibration transmission variables, it was found that the LW/FH, RW/FH, LA/RH, and RA/RH ratios were higher in the 29" bicycle than in 26" one. Average heart rate (p = 0.01) and maximum heart rate (p < 0.01) values were higher for the 29" bike with no significant differences in the average power values recorded. In conclusion, bicycles with 29" wheels transmit higher levels of vibration to riders.
Analysis of the dynamic relationship between immune profiles and the clinical features of patients with COVID-19

Background The novel coronavirus disease (COVID-19) has been declared a global pandemic, with the cumulative number of confirmed cases and deaths exceeding 150 million and 3 million, respectively. Here, we examined the dynamic changes in the immune and clinical features of patients with COVID-19. Methods Clinical data of 98 patients with confirmed COVID-19 diagnosis were acquired from electronic medical records and curated. The data were analyzed based on the stage of the admission, deterioration, and convalescence, which included age, sex, severity, disease stages, biochemical indicators, immune cells, inflammatory cytokines, and immunoglobulins. Additionally, temporal changes in the immune response in patients undergoing continuous renal replacement therapy (CRRT) were also examined. Results Compared to mild stage patients, severe stage patients with COVID-19 exhibited a significant reduction in lymphocyte [23.10 (17.58–33.55) vs. 4.80 (2.95–6.50), P<0.001], monocyte [8.65 (7.28–10.00) vs. 3.45 (2.53–4.58), P<0.001], and NK cell levels [244.00 (150.50–335.00) vs. 59.00 (40.00–101.00), P<0.001] but showed elevated levels of neutrophils [64.90 (56.30–73.70) vs. 90.95 (87.60–93.68), P<0.001], inflammatory cytokines [Interleukin-10, 3.05 (1.37–3.86) vs. 5.94 (3.84–8.35), P=0.001; and tumor necrosis factor-α, 11.50 (6.55–26.45) vs. 12.96 (12.22–36.80), P=0.029], which improved during convalescence. Besides, the number of immune cells—T lymphocytes, B lymphocytes, helper T cells, suppressor T cells, NK cells, and monocytes, except neutrophils—slowly increased in critically ill patients receiving CRRT from 0 to 3 weeks. Conclusions Our results indicate that the surveillance of immune cells may contribute to monitoring COVID-19 disease progression, and CRRT is a potential therapeutic strategy to regulate the immune balance in critically ill patients.