Miracle-dz/UniFAR-FTUs huggingface dataset:
Sex‐dependent and sex‐independent regulatory systems of size variation in natural populations

Size of organs/organisms is a polygenic trait. Many of the growth‐regulatory genes constitute conserved growth signaling pathways. However, how these multiple genes are orchestrated at the systems level to attain the natural variation in size including sexual size dimorphism is mostly unknown. Here we take a multi‐layered systems omics approach to study size variation in the Drosophila wing. We show that expression levels of many critical growth regulators such as Wnt and TGFβ pathway components significantly differ between sexes but not between lines exhibiting size differences within each sex, suggesting a primary role of these regulators in sexual size dimorphism. Only a few growth genes including a receptor of steroid hormone ecdysone exhibit association with between‐line size differences. In contrast, we find that between‐line size variation is largely regulated by genes with a diverse range of cellular functions, most of which have never been implicated in growth. In addition, we show that expression quantitative trait loci (eQTLs) linked to these novel growth regulators accurately predict population‐wide, between‐line wing size variation. In summary, our study unveils differential gene regulatory systems that control wing size variation between and within sexes.
Evaluating patterns of inconsistent and missing data on the eating disorders examination-questionnaire in a sample of treatment-seeking adults and adolescents

ABSTRACT Missing or inconsistent responses on self-report assessments can have implications for the use of empirically validated measurements in research and clinical practice. However, literature on frequency and systematic patterns of missingness on common measures of eating pathology is lacking. The current study evaluated EDE-Q missing and inconsistent responding in a clinical eating disorders (EDs) sample (N = 739). Thirteen percent (13.4%; n = 99) of the sample failed to provide complete responses on the EDE-Q and 13.8% (n = 101) inconsistently responded to behavioral items of the EDE-Q. Males were more likely to provide missing data, and mean BMI was higher among individuals with missing responses. Inconsistent responders endorsed higher scores on several EDE-Q subscales, were younger, and were more likely to be Hispanic/Latinx. However, many of these differences were not significant following correction for multiple comparisons. Although our results indicated similar rates of missingness and inconsistency to past work in college samples, our results suggest that missing and inconsistent responding on the EDE-Q in clinical samples may not warrant specialized consideration within statistical analyses.
An Anthocyanin-Rich Mixed-Berry Intervention May Improve Insulin Sensitivity in a Randomized Trial of Overweight and Obese Adults

Evidence supports the beneficial effects of berries on glucoregulation, possibly related to flavonoid content, fiber content, or both. The purpose of this study was to assess the potential of mixed berries to improve insulin sensitivity and to identify the potential role of flavonoids and fiber. In a randomized cross-over trial with four treatment periods, overweight/obese men and women were fed a controlled 45% fat diet for one week prior to a meal-based glucose tolerance test. The same base diet was provided during each feeding period with the addition of one of four treatments: whole mixed berries, sugar matched mixed berry juice, sugar matched gelatin, and sugar/fiber matched gelatin. Subjects then completed a meal-based oral glucose tolerance test. Serum glucose, insulin and non-esterified fatty acids were not different between individual treatments. However, in a secondary analysis, the combined berry preparations resulted in a lower serum insulin area under the curve (difference of 0.15 ± 0.066 ln pmol min/mL, mean ± SE, p = 0.0228), compared to the combined gelatin treatments, while the difference for serum glucose did not quite meet statistical significance (difference of 0.17 ± 0.093 ln mg·min/dL, mean ± SE, p = 0.0738). These results suggest the potential for mixed berry preparations to improve post-prandial insulin response.
Prediction of the Levodopa Challenge Test in Parkinson’s Disease Using Data from a Wrist-Worn Sensor

The response to levodopa (LR) is important for managing Parkinson’s Disease and is measured with clinical scales prior to (OFF) and after (ON) levodopa. The aim of this study was to ascertain whether an ambulatory wearable device could predict the LR from the response to the first morning dose. The ON and OFF scores were sorted into six categories of severity so that separating Parkinson’s Kinetigraph (PKG) features corresponding to the ON and OFF scores became a multi-class classification problem according to whether they fell below or above the threshold for each class. Candidate features were extracted from the PKG data and matched to the class labels. Several linear and non-linear candidate statistical models were examined and compared to classify the six categories of severity. The resulting model predicted a clinically significant LR with an area under the receiver operator curve of 0.92. This study shows that ambulatory data could be used to identify a clinically significant response to levodopa. This study has also identified practical steps that would enhance the reliability of this test in future studies.
A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer

Objective There is a need for early detection of colorectal cancer (CRC) at precancerous-stage adenoma. Here, we identified novel faecal bacterial markers for diagnosing adenoma. Design This study included 1012 subjects (274 CRC, 353 adenoma and 385 controls) from two independent Asian groups. Candidate markers were identified by metagenomics and validated by targeted quantitative PCR. Results Metagenomic analysis identified ‘m3’ from a Lachnoclostridium sp. , Fusobacterium nucleatum (Fn) and Clostridium hathewayi (Ch) to be significantly enriched in adenoma. Faecal m3 and Fn were significantly increased from normal to adenoma to CRC (p<0.0001, linear trend by one-way ANOVA) in group I (n=698), which was further confirmed in group II (n=313; p<0.0001). Faecal m3 may perform better than Fn in distinguishing adenoma from controls (areas under the receiver operating characteristic curve (AUROCs) m3=0.675 vs Fn=0.620, p=0.09), while Fn performed better in diagnosing CRC (AUROCs Fn=0.862 vs m3=0.741, p<0.0001). At 78.5% specificity, m3 and Fn showed sensitivities of 48.3% and 33.8% for adenoma, and 62.1% and 77.8% for CRC, respectively. In a subgroup tested with faecal immunochemical test (FIT; n=642), m3 performed better than FIT in detecting adenoma (sensitivities for non-advanced and advanced adenomas of 44.2% and 50.8% by m3 (specificity=79.6%) vs 0% and 16.1% by FIT (specificity=98.5%)). Combining with FIT improved sensitivity of m3 for advanced adenoma to 56.8%. The combination of m3 with Fn, Ch, Bacteroides clarus and FIT performed best for diagnosing CRC (specificity=81.2% and sensitivity=93.8%). Conclusion This study identifies a novel bacterial marker m3 for the non-invasive diagnosis of colorectal adenoma.
Changes in Body Composition, Energy Metabolism, and Appetite-Regulating Hormones in Korean Professional Female Ballet Dancers before and after Ballet Performance

This study investigated changes in body composition, energy balance, and appetite-regulating hormones in professional female ballet dancers before and after 3 days of ballet performances. The subjects were 43 professional female ballet dancers in Korea. The mean age of the subjects was 25.9 ± 2.8 years, and they had over 13 years of ballet training on average. For body composition, the body mass index (BMI), percent body fat (%BF), lean body mass (LBM), and total body water (TBW) were evaluated. By way of blood analysis the serum levels of ghrelin, leptin, and insulin were examined. The calculations of energy intake (EI) and expenditure (EE) were based on journals that were self-recorded by the subjects for 14 days. For statistical analysis, the dependent sample t-test was applied (p < 0.05). The results showed no significant change in %BF, but the BMI, LBM, and TBW increased significantly in the post-performance measurement. Energy balance results demonstrated a significant increase in EI and decrease in EE. Both the ghrelin and leptin levels increased significantly. Although reported energy intake increased after performances, it remained below estimated energy requirements. Ballet dancers should be aware of the need to maintain energy balance in order to optimize their health and performance.
Discovering novel disease comorbidities using electronic medical records

Increasing reliance on electronic medical records at large medical centers provides unique opportunities to perform population level analyses exploring disease progression and etiology. The massive accumulation of diagnostic, procedure, and laboratory codes in one place has enabled the exploration of co-occurring conditions, their risk factors, and potential prognostic factors. While most of the readily identifiable associations in medical records are (now) well known to the scientific community, there is no doubt many more relationships are still to be uncovered in EMR data. In this paper, we introduce a novel finding index to help with that task. This new index uses data mined from real-time PubMed abstracts to indicate the extent to which empirically discovered associations are already known (i.e., present in the scientific literature). Our methods leverage second-generation p-values, which better identify associations that are truly clinically meaningful. We illustrate our new method with three examples: Autism Spectrum Disorder, Alzheimer’s Disease, and Optic Neuritis. Our results demonstrate wide utility for identifying new associations in EMR data that have the highest priority among the complex web of correlations and causalities. Data scientists and clinicians can work together more effectively to discover novel associations that are both empirically reliable and clinically understudied.
Survey of Pretreatment HIV Drug Resistance and Genetic Transmission Network Analysis Among HIV Patients in a High Drug-Use Area of Southwest China

Background: Pretreatment drug resistance (PDR) poses an increasing threat to the success of antiretroviral treatment (ART) programs in China. We aimed to conduct a survey of PDR among HIV patients in an area in Southwest China with extensive drug trafficking. Methods: Consecutive cross-sectional surveys were conducted in Liangshan Prefecture of Sichuan Province from 2009 to 2018 based on the WHO-recommended method. PDR was identified by testing pol region sequences with the Stanford HIVdb algorithm (version 7.0). PDR prevalence and related factors were assessed by multivariable logistic regression. The transmission of HIV drug resistance was analyzed using a genetic transmission network. Results: HIV-1 pol genes from 1889 patients were successfully amplified. The distribution of HIV-1 genotypes was as follows: CRF07_BC (94.0%), CRF08_BC (2.3%), CRF01_AE (2.0%) and others (1.4%). Of the participants, 6.9% (95% CI: 4.1-8.1%) had pretreatment resistance to 12 antiretroviral drugs recommended by the WHO, and nucleoside reverse transcriptase inhibitor (NRTI), non-nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitors (PI) resistance were identified among 1.4% (95% CI: 0.7-3.4%), 5.8% (95% CI: 1.2-8.7%) and 0.4% (95% CI: 0.1-3.0%) of the patients, respectively. In the multivariate logistic model, the prevalence of PDR was 1.52-fold higher among intravenous drug users (IDUs) than among patients infected by heterosexual transmission (95% CI: 1.07-2.38; P=0.049), and the prevalence of PDR among patients diagnosed from 2017-2018 was 2.03-fold higher than that among patients diagnosed from 2009-2016 (95% CI: 1.18-5.76; P=0.018). A total of 26 clusters containing PDR and a rapidly growing drug resistance-related cluster containing the E138Q and V179D mutations were identified by genetic transmission network analysis. Conclusion: The results show a moderate overall level of PDR prevalence and rapidly growing drug resistance over time. Preventive intervention should be focused on controlling the HIV epidemic among drug users, and surveillance is urgently needed to monitor the trend of PDR.
Prevalence of common causes of neuropathic pain in Korea: population-based observational study

Objective To investigate the prevalence of complex regional pain syndrome (CRPS), post-herpetic neuralgia (PHN), trigeminal neuralgia (TN), and diabetic neuropathy (DN), common causes of neuropathic pain encountered in pain clinics. Methods We investigated the period prevalence rate of CRPS, PHN, TN, and DN using data from a Korean national electronic database from 2009 to 2013. Results The prevalence of CRPS decreased slightly throughout the study period, while the prevalence of PHN increased from 2009 to 2013. The prevalence of TN was reduced over the same period. The prevalence of DN increased from 2009 to 2012 but decreased in 2013. All four neuropathic diseases were more prevalent in individuals aged over 70 years. The prevalence of CRPS, PHN, and TN were more common in women than in men, but DN showed no gender difference. Conclusion While the prevalence of CRPS and TN has decreased in Korea, that of PHN and DN has increased. With the exception of DN, the neuropathic diseases were more prevalent in women. Further studies are necessary to investigate the risk factors and socioeconomic burden for each disease, and national efforts are essential to limit the development of these preventable neuropathic diseases.
Patient Engagement Survey Regarding Future Double-Blinded, Randomized Controlled Trial of Tapering of Chronic Opioid Therapy

Objective: There is a lack of evidence regarding tapering opioid medications in patients with chronic non-cancer pain. The purpose of this survey was to gather perspectives on future research into opioid tapering from utilizers of chronic opioid therapy (COT) or other people affected by chronic noncancer pain. Methods: The survey was distributed in paper form to patients on COT and via an online platform to patients self-enrolled in the chronic pain patient engagement group. The survey included a layman’s description of a possible tapering trial of opioid medications and elicited binary responses regarding willingness to participate and reasoning as well as qualitative freeform responses. Thematic analysis was performed to identify themes in narrative responses. Results: A total of 190 surveys were returned with 72.1% of all respondents answering positively regarding their willingness to participate in a proposed study. The most common reasons for participating in the study included concerns regarding opioid dependence, adding to society’s knowledge of opioid medications, and determining if the respondent would personally receive benefit from opioid medications. Patients recently on COT felt it was important to be able to withdraw from the study and return to usual care at any time (41.8% for recent COT and 15.5% for no recent COT, P < .05). The most common reason for unwillingness to participate was that respondents did not feel they had enough information to feel comfortable participating. The narrative responses showed a group of respondents felt COT was the only answer to their or their loved ones’ chronic pain and that a study would demonstrate the need to continue these medications long-term. There were also stories of side effects and dependence with decreasing effectiveness of opioids for pain control. When prompted to comment on study design, respondents indicated the study should include alternative pain management options. This was accompanied by responses with the assumption that pain will worsen as opioid medications are decreased. Conclusion: Patient concerns regarding opioid medications and discontinuation reflect the lack of evidence available to prescribers. There appears to be patient support for future research into the effects of tapering opioid medications.
Fitness consequences of different migratory strategies in partially migratory populations: A multi‐taxa meta‐analysis

Abstract Partial migration—wherein migratory and non‐migratory individuals exist within the same population—represents a behavioural dimorphism; for it to persist over time, both strategies should yield equal individual fitness. This balance may be maintained through trade‐offs where migrants gain survival benefits by avoiding unfavourable conditions, while residents gain breeding benefits from early access to resources. There has been little overarching quantitative analysis of the evidence for this fitness balance. As migrants—especially long‐distance migrants—may be particularly vulnerable to environmental change, it is possible that recent anthropogenic impacts could drive shifts in fitness balances within these populations. We tested these predictions using a multi‐taxa meta‐analysis. Of 2,939 reviewed studies, 23 contained suitable information for meta‐analysis, yielding 129 effect sizes. Of these, 73% (n = 94) reported higher resident fitness, 22% (n = 28) reported higher migrant fitness, and 5% (n = 7) reported equal fitness. Once weighted for precision, we found balanced fitness benefits across the entire dataset, but a consistently higher fitness of residents over migrants in birds and herpetofauna (the best‐sampled groups). Residency benefits were generally associated with survival, not breeding success, and increased with the number of years of data over which effect sizes were calculated, suggesting deviations from fitness parity are not due to sampling artefacts. A pervasive survival benefit to residency documented in recent literature could indicate that increased exposure to threats associated with anthropogenic change faced by migrating individuals may be shifting the relative fitness balance between strategies.
The Property Characterization of α-Sialon/Ni Composites Synthesized by Spark Plasma Sintering

This study investigates the effect of micron-sized nickel particle additions on the microstructural, thermal, and mechanical property changes of α-sialon ceramic composites. The α-sialon/Ni composites were synthesized with an increasing amount of Ni (10–40 wt.%) using the spark plasma sintering technique and nanosized alpha precursors at a relatively low synthesis temperature of 1500 °C with a holding time of 30 min in each case. The density of the samples increased with the increase in Ni content of up to 15 wt. % and, with the further increase in Ni content, it became almost constant with a slight decrease. Furthermore, thermal conductivity and thermal expansion properties of Ni-sialon composites improved slightly with the inclusion of 10 wt. % Ni. The addition of Ni to α-sialon matrix resulted in a decrease in the hardness of the composites from HV10 21.6 to HV10 16.3, however the presence of Ni as a softer interfacial phase resulted in a substantial increase in the fracture toughness of these composites. Fracture toughness was found to increase by approximately 91% at 40 wt. % Ni addition.
Psychological well-being and distress in patients with generalized anxiety disorder: The roles of positive and negative functioning

Background Whether mindfulness and emotional intelligence may counteract psychological symptoms and whether brooding and worry may be linked to decreased psychological well-being (PWB) in individuals with generalized anxiety disorder (GAD) is still an issue. Methods The study used a cross-sectional design on a sample of 66 consecutive individuals with a diagnosis of GAD. Two hierarchical multiple regressions were conducted to determine whether PWB and anxiety symptoms were accounted for by mindfulness and emotional intelligence skills, brooding, and worry. Results Worry was negatively related to PWB and showed a tendency to be positively associated with anxiety symptoms after controlling for the other variables. Brooding was uniquely and positively related to anxiety symptoms. Different mindfulness (i.e., describing and nonjudging) and emotional intelligence (i.e., attention and repair) skills were particularly important for PWB. Repair was also negatively related to anxiety symptoms. Conclusions Repair was the variable that played a key role in the association with both PWB and GAD symptoms. Worry was the second most important variable, although it approached significance in the relationship with anxiety symptoms. Brooding was more strongly positively associated with anxiety than worry. In sum, the results suggest that an integrated and balanced focus on both positive and negative functioning will be useful in future clinical psychology research to predict, understand, and treat anxiety as well as to examine the antecedents and characteristics of positivity in individuals with GAD and promote their PWB.
Traumatic Brain Injury: Persistent Misconceptions and Knowledge Gaps among Educators.

Each year approximately 700,000 U.S. children aged 0–19 years sustain a traumatic brain injury (TBI) placing them at risk for academic, cognitive, and behavioural challenges. Although TBI has been a special education disability category for 25 years, prevalence studies show that of the 145,000 students each year who sustain long-term injury from TBI, less than 18% are identified for special education services. With few students with TBI identified for special education, TBI is mistakenly viewed as a low-incidence disability, and is covered minimally in educator preparation. We surveyed educators and found that they lacked knowledge, applied skills, and self-efficacy in working with students with TBI. While those with special education credentials and/or additional training scored significantly higher than general educators, all demonstrated inadequate skills in working with students with TBI. This finding suggests that teachers, especially those in general education, have misconceptions and knowledge gaps about TBI and its effects on students. Misconceptions have led to the misidentification and underidentification of students with TBI, leaving this group of students with disabilities potentially underserved. To meet the academic and behavioural needs of students with TBI, all educators need effective training in working with students with TBI. ISSN 1918-5227 Pages 118 This project was supported by the U.S. Department of Education, National Institute on Disability and Rehabilitation Research, Grant Number H133B090010-13. Follow this and additional works at: https://ir.lib. uwo.ca/eei Part of the Other Teacher Education and Professional Development Commons Recommended Citation Ettel, PhD, NCSP, D. , Glang, A. E. , Todis, B. , & Davies, S. C. (2016) Traumatic Brain Injury: Persistent Misconceptions and Knowledge Gaps Among Educators. Exceptionality Education International, 26, 1-18. Retrieved from https://ir.lib. uwo.ca/eei/vol26/iss1/1 This Article Open Access after 1 year is brought to you by Scholarship@Western. It has been accepted for inclusion in Exceptionality Education International by an authorized administrator of Scholarship@Western. For more information, please contact jspecht@uwo.ca. Traumatic Brain Injury: Persistent Misconceptions and Knowledge Gaps Among Educators Cover Page Footnote This project was supported by the U.S. Department of Education, National Institute on Disability and Rehabilitation Research, Grant Number H133B090010-13. This article open access after 1 year is available in Exceptionality Education International: https://ir.lib. uwo.ca/eei/ vol26/iss1/1 Exceptionality Education International 2016, Vol. 26, No. 1, pp. 1–18 ISSN 1918-5227 1 Traumatic Brain Injury: Persistent Misconceptions and Knowledge Gaps Among Educators Deborah Ettel Eugene School District 4J Ann E. Glang, Bonnie Todis University of Oregon Susan C. Davies University of Dayton