Miracle-dz/UniFAR-FTUs huggingface dataset:
The differences in troponin values among gender in COVID-19 patients

The aim of this study is to investigate the differences on admission troponin values among gender in hospital outcomes and in the 2-year follow-up period in coronavirus disease (COVID-19) patients. Data of 826 patients with moderate-to-severe COVID-19 disease were analyzed retrospectively. All patients had nasal and oropharyngeal swab samples taken according to Ministry of Health guidelines on admission. Patients were divided into female (n = 438) and male (n = 388) groups and were follow-up for 2 years. Clinical events such as need for intensive care unit, respiratory failure, need for inotropic initiation, acute renal failure, cardiac injury, and in-hospital mortality were also recorded. The cumulative endpoints were determined as all-cause mortality, re-hospitalization, and stroke during the 2-year follow-up period. Also, factors affecting the cumulative endpoints were investigated. In clinical events and cumulative endpoints, the differences of troponin values between the gender were investigated and the factors causing cardiac injury were determined separately in men and women. Mean age (59.43 ± 19.15 vs 58.14 ± 16.66) and comorbidities were significantly higher in the female group. There were no differences between genders in terms of clinical events except respiratory failure, which was more frequent in the male group (P = .016). In-hospital survivor rate in the female group was 16 ± 2.5 days (95% confidence interval: 11.08–20.91), in the male group was 14 ± 0.92 days (95% confidence interval: 12.18–15.81) P = . 008, while there were no differences between groups among in-hospital morality rates (P = .208). During the 2-year follow-up period cumulative endpoints were more in the male group (P < .05). Troponin value in female ≥ 93 pg/mL, in male ≥ 28 pg/mL was related with cardiac injury. All clinical events occur at lower troponin values in the male group. In both groups, independent risk factors for in-hospital mortality were troponin and the existence of fragmented QRS; for cumulative endpoints were respiratory failure, cardiac injury, and age. We observed that in COVID-19 disease, troponin value differs by gender. A lesser increase in troponin levels in men was indicative of cardiac injury. Even slight increases in troponin levels in men should alert clinicians for cardiac injury and other clinical events.
Redefining the Upper Jurassic Morrison Formation in Garden Park National Natural Landmark and vicinity, eastern Colorado: Geology of the Intermountain West

The Garden Park National Natural Landmark (GPNNL) is north of Cañon City, Colorado, and encompasses all of the major historical dinosaur quarries of the Upper Jurassic Morrison Formation in this area. The formation there can be divided into the lower redefined Ralston Creek Member and an upper unnamed member. The Morrison Formation is bracketed below by the J-5 unconformity and above by the K-1 unconformity. The Ralston Creek Member is composed of up to 55 m of arkosic conglomerate, sandstone, siltstone, and gypsum conformably underlying the unnamed member. Fossil fishes previously used to infer a Middle Jurassic age are non-diagnostic. A diplodocid skeleton 4 m above the J-5 unconformity from the west-adjacent Shaws Park, and a radiometric date of 152.99 + 0.10 Ma from the Purgatoire River area demonstrate that the Ralston Creek rightly belongs in the Morrison Formation and correlates with the Tidwell and Salt Wash Members on the Colorado Plateau. The Ralston Creek was deposited in a broad playa complex analogous to those of central Australia and here called the Ralston Creek boinka. Groundwater flux played an important role in gypsum deposition in gypsisols and playa lakes. The overlying unnamed member in the GPNNL can be subdivided on the west side of Fourmile Creek into a lower part composed largely of mudstone with many thin, discontinuous channel sandstone beds, and a thicker upper part containing more persistent tabular sandstone beds; this subdivision does not occur east of Fourmile Creek. Several thin limestone beds occur in the Ralston Creek Member and in the lower part of the unnamed upper member. The limestone contains fresh water ostracods and aquatic mollusks indicating a lacustrine origin. However, these fauna are apparently stunted and the ostracod valves closed indicating periodic hypersaline conditions. All detrital rocks in the Morrison Formation at Garden Park are composed of varying amounts of quartz, potassic feldspar, and the clay minerals illite, smectite, and kaolinite. Mapping of the clay minerals in the unnamed member reflect various paleosols throughout the mudstone interval, including protosols and argillisols. At the top of the formation, a sandstone previously assigned to the Morrison is reassigned to the overlying Cretaceous Lytle Formation based on similar weathering characteristics, mineral content, and fabric. Thus, the K-1 unconformity between the Morrison and overlying Lytle rests on the uppermost occurrence of the Morrison Formation mudstone-sandstone-limestone complex and beneath the blocky, cliff-forming Lytle Formation.
Ag/Au total production ratio and Au-Ag minerals from vein-type and disseminated-type deposits in Japan

Ag/Au total production ratio and Au-Ag minerals from three types of Japanese deposits, which have produced both gold and silver, are summarized. These deposits include, Au-Ag vein (Type 1-A), base metal (Cu, Pb, Zn, Mn, (Sn), (W), (Bi), (Mo), (Sb)) vein (Type 1-B), and Au rich disseminated-type ones (Type 2). Generally, base metal rich deposits (Type 1-B) are characterized by that, (1) the Ag/Au total production ratio is high, (2) dominant Ag minerals are Se poor argentite and sometimes Ag sulfosalts (pyrargyrite, polybasite, argentian tetrahedrite), (3) Se and Te-bearing Au-Ag minerals are absent, and (4) Sn, W, and Bi minerals are sometimes found. In contrast, Au-Ag rich deposits (Type 1-A and Type 2) have the following features; (1) the Ag/Au total production ratio is low, (2) dominant Ag minerals in Type 1-A are Ag-Se-S minerals (naumannite, aguilarite, and Sebearing argentite), and Ag sulfosalts (polybasite, pyrargyrite, argentian tetrahedrite), (3) Hg, As, Sb, and Te minerals are occasionally found, (4) in Type 2, Ag minerals except Au-Ag series minerals are rare. The above differences in the mineralogical characteristics of the Au-Ag rich and base metal rich deposits are considered to be resulted from the differences in chemical nature of ore fluids (sulfur and oxygen activities, CO2 concentration, pH and temperature), depositional mechanism and depth of formation. The relationship between Ag/ Au total production ratio and kinds of metals concentrated to the deposits found in the Japanese deposits is also observed in epithermal Au-Ag vein-type deposits in western U.S.A. and active geothermal systems accompanied by precipitations of base metal and precious metals.
Usage trends of colorectal endoscopic submucosal dissection according to hospital types based on nationwide claims data

Although the use of colorectal endoscopic submucosal dissection (ESD) for colorectal lesions has increased, there is a lack of analysis of the recent usage trends of ESD. Thus, this study aimed to identify changes in the annual utilization of ESD and determine the proportion of surgeries after ESD according to hospital types. Using Health Insurance Review and Assessment data from 2012 to 2019, 26,502 colorectal ESD cases were analyzed to assess the annual usage trends of ESD according to hospital type, additional early and late surgeries after ESD, changes in the distribution of colorectal lesions, and factors associated with early and late surgery. Trend analysis was performed using the chi-squared test for trend in proportions. Colorectal ESD increased from 2046 in 2012 to 5319 in 2019. Additional early and late surgeries rose from 135 (6.6%) in 2012 to 441 (8.2%) in 2019 (P < .05) and from 9 (0.3%) in 2013 to 52 (1.0%) in 2019 (P < .05), respectively. In tertiary and general hospitals, the proportion of submucosal cancers decreased, whereas the proportion of intramucosal cancers increased. Submucosal cancer was associated with early (odds ratio: 108.90, 95% confidence interval: 61.67–192.35) and late surgery (odds ratio: 3.55, 95% confidence interval: 2.27–5.56). Using nationwide data, our study identified the clinical usage trends of colorectal ESD based on the annual increase in utilization and the proportion of additional surgeries after ESD.
Disseminated disease caused by Mycobacterium marseillense: A case report and literature review

Rationale: Among numerous types of nontuberculous mycobacterial infections, Mycobacterium avium complex is a related group of species, which can cause various diseases in humans. Mycobacterium marseillense is a member of the Mycobacterium avium complex, which accounts for only a small proportion of species, but causes rare diseases affecting the lungs, lymph nodes, skin, and tendon sheath. So far, very few cases have been reported. Patient concerns: A 76-year-old male of peculiar skin infection. Metagenomic Next Generation Sequencing and bacterial culture of skin secretions revealed M marseillense. To the best of our knowledge, we report the first patient diagnosed with disseminated M marseillense infection. Here, we identified only 8 other reports of patients with M marseillense infection. Diagnoses: Disseminated M marseillense infection. Interventions: The patient was treated with clarithromycin, rifampicin, moxifloxacin, and ethambutol. Outcomes: The skin lesions of the patient showed significant improvement, and his pruritus and limb pain were notably reduced after 7 months of follow-up. Lessons: Metagenomic Next Generation Sequencing may be a useful tool to diagnose M marseillense infection, but the results should be confirmed by culture and mycobacterial identification.
Business Cycle Association and Synchronization in Europe : a Descriptive Review

The share of a single currency inside a continent where the social, political and economic conditions are heterogeneous provokes a new wave of research on the effects of convergence in economic policies, monetary and non-monetary. The effects of Maastricht treaty and its nominal convergence criteria, helped many European countries to achieve nominal stability and start with new and controlled monetary and fiscal policies in order to slow down inflation and decrease interest rates. According to Angeloni and Dedola (1999) the European countries seem to have engaged in a new form of synchronized policies since the Bretton-Woods era to the period of the Exchange Rate Mechanism (ERM) and the beginning of the European Monetary Union (EMU). Taking this into account, the goal of this paper is to test the hypothesis that the launch of the currency union in Europe increased the cyclical synchronization between the participating countries. This hypothesis is tested by providing a descriptive analysis of the cyclical position of 26 countries from Europe in relation to the Euro Area aggregate for the period 1983-2002.
Jarosite occurrence in the Deccan Volcanic Province of Kachchh, western India: Spectroscopic studies on a Martian analog locality

The sulfate mineral jarosite is considered a key indicator of hydrous, acidic, and oxidizing conditions on the surface of early Mars. Here we report an analog terrestrial locality hosting jarosite from Matanumadh, Kachchh, western India, using detailed spectroscopic studies on weathered basalts of the Deccan Volcanic Province and overlying tuffaceous shales and sandstones of the Matanumadh Formation. Hyperspectral data in the visible/near‐infrared (350–2500 nm) to midinfrared (4000–400 cm−1) region of the electromagnetic spectrum and X‐ray diffraction patterns have been acquired on samples collected from the field to detect and characterize the hydrous sulfate and phyllosilicate phases present at the studied site. Hydrous sulfates occur in association with Al‐rich phyllosilicates (kaolinite) that overlie a zone of Fe/Mg smectites in altered basalts. Jarosite is found within both saprolitic clay horizons altered from the basalt and within variegated sandstone and shale/clay units overlying the saprolite; it mostly occurs as secondary veins with or without gypsum. Jarosite is also seen as coatings on kaolinite clasts of varying shapes and sizes within the tuffaceous variegated sandstone unit. We argue that the overall geological setting of the Matanumadh area, with this unusual mineral assemblage developing within altered basalts and in the overlying sedimentary sequence, mimics the geological environment of many of the identified jarosite localities on Mars and can be considered as a Martian analog from this perspective.
Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study

Cholesteatoma is a noncancerous cystic lesion caused by an abnormal growth of keratinizing squamous epithelium which is invasive and capable of destroying structures. A prospective study on the expression of membrane type1-matrix metalloproteinases (MMP-14) and its related influencing factors in middle ear cholesteatoma was conducted to fully understand the pathogenesis of cholesteatoma in the molecular level. We examined the expression of MMP-14 by immunohistochemical staining 39 middle ear cholesteatoma specimens and 10 external auditory meatus epithelial cell specimens. The cholesteatoma specimens were divided into 4 groups according to the degree of destruction of the ossicles during surgery. The associated factors affecting MMP-14 expression were analyzed using statistical methods; The positive expression of MMP-14 in the epithelium of the external auditory canal was significantly different between middle ear cholesteatoma and normal patients (P < .05); Gender, age, and the degree of hearing loss had no statistically significant effect on MMP-14 expression (P > .05); The expression of MMP-14 was positively correlated with the severity of bone destruction (R = 0.535, P < .05); MMP-14 plays an important role in the pathological development of the epithelium of cholesteatoma; MMP-14 expression in middle ear cholesteatoma tissue was not strongly correlated with the level of hearing loss, age or gender, but was positively correlated with the degree of middle ear bone destruction.
An overview of stem cell transplant as a treatment for cancer.

T National Cancer Institute estimates that 10.1 million Americans have a history of cancer, and that three of every four American families will have at least one family member diagnosed with the disease (National Cancer Institute, 2006). Stem cell transplantation (SCT) has been used for over 50 years (Kolb, Gidwani, & Grupp, 2006) to treat a multitude of cancers and non-myelodysplastic diseases after patients have completed standard treatment regimes. SCT usually is used to treat hematologic and lymphoid cancers, such as acute lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, Hodgkin’s disease, multiple myeloma, and non-Hodgkin’s lymphoma (Copelan, 2006). Transplantation early in the course of the disease is critical in patients with hematologic cancers (Copelan, 2006). Every year thousands of patients undergo SCT to “rescue” them from highdose chemotherapy, which ablates the bone marrow (Ball, 2003). Other disease entities that are now being treated with SCT include genetic diseases, acquired anemias, germ cell tumors, primary amyloidosis, myelodysplastic diseases, neuroectodermal tumors and ependymoma, ovarian cancer and germ cell tumors arising in the ovaries, solid tumors of childhood, and other diseases classified as rare diseases (Copelan, 2006; Kolb et al., 2006). Additionally, SCT is still considered investigational for numerous nonmalignant autoimmune diseases such as lupus, but may offer a cure or a better quality of life (Burt et al., 2006; Petri & Brodsky, 2006). Because many medical-surgical nurses will come in contact with SCT patients before and after the actual transplants (and perhaps due to staffing shortages within specialized transplant units), stem cell use in combating malignancy and the nurse’s role in the process will be described. Nursing care and the complexity of this care continue to change, and nurses must respond to and reassess the need for practice changes constantly to provide high-quality care. CNE Objectives and Evaluation Form appear on page 190.
Impact of workplace bullying on work engagement among early career employees

This study aims to measure the impact of workplace bullying on work engagement in terms of employee silence and knowledge sharing. It also helps to explain how psychological contract breach moderates the bullying-silence relationship. For this study, data is collected from 384 early-career employees having experience up to three years from seven banks of Lahore, Pakistan. Findings of this study reveals that workplace bullying has a positive relationship with employee silence and negative relationship with work engagement. Results of all moderation and mediated variables are significantly related to each other. However, the results explain that a psychological contract breach slightly moderates the bullying-silence relationship. Survey-based questionnaire, cross-sectional research design, and convenience-based sampling technique are some of the limitations of this study. This is the first study that tried to investigate the bullying-engagement relationship among early-career employees in the banking sector of Lahore, Pakistan. This study may help practitioners and policymakers to develop anti-bullying laws that can support the management in overcoming the negative workplace environment. This study aims to promote an equal opportunity for all employees where they can raise their voices about misconduct. This is the first study that investigated the victimization of bullying behavior among early-career employees in a Pakistani cultural context.
Measuring performance in a changing business environment

The design and use of performance measurement systems has received considerable attention in recent years. Many organisations have redesigned their measurement systems to ensure that they reflect their current environment and strategies. However, increasingly the environment in which organisations compete is dynamic and rapidly changing, requiring constant modification of strategies and operations to reflect these changing circumstances. Despite this, few organisations appear to have systematic processes in place to ensure that their performance measurement systems continue to reflect their environment and strategies. This paper presents case study research that investigates what actions organisations can take to ensure that their measurement systems evolve over time.
Prevalence, clinical profile, and risk factors of peripheral artery disease in an Iraqi cohort of chronic kidney disease

Peripheral artery disease (PAD) is prevalent in patients with chronic kidney disease (CKD) and is associated with substantial morbidity, mortality, and a lower quality of life. This study aimed to determine the prevalence of PAD, clinical profile, and related risk factors among patients with CKD in Iraq (a low-to middle-income country). A cross sectional study comprised 175 CKD patients, of them 60% were male, their mean age was 56 ± 12.5 years, attending Nephrology unit, Hawler Teaching Hospital, Erbil, Iraq between march 2022 and November 2022. Data on demographic and baseline characteristics were collected. Laboratory tests were performed. All participants underwent a detailed history and clinical examination. Vascular lesions in the lower limbs were assessed using the ankle-brachial index. PAD was diagnosed based on an ankle-brachial index value ˂ 0.9, relevant symptoms, and clinical findings. Forty-nine patients (28%) had PAD, and only 17 (34.7%) were symptomatic. PAD was significantly associated with older age (P = .008), male sex (P = .039), diabetes (P = .012), and hypertension (P = .023). In addition, PAD prevalence was significantly higher in patients with prior coronary artery disease (P < .001), advanced CKD stages (P .032), low estimated glomerular filtration rate (P .03), albuminuria (P .002), elevated glycated hemoglobin (P .04), and high sensitive C-reactive protein (P < .001). No significant association was detected between PAD and body mass index, smoking, CKD duration, cerebrovascular disease, dyslipidemia, albumin, creatinine, hemoglobin, total PTH, and phosphate. Peripheral artery disease was prevalent in patients with CKD in Iraq, and the most affected patients were asymptomatic. Older age, male sex, hypertension, diabetes, prior coronary artery disease, advanced CKD stages, albuminuria, higher glycated hemoglobin level, and increased high-sensitivity C-reactive protein level were identified as risk factors. Early detection of occult PAD might enhance efforts toward proper prevention and treatment.
RRP9 and DDX21 as new biomarkers of colorectal cancer

Colorectal cancer originates from the epithelium of the large intestine and is a common malignant tumor in the gastrointestinal tract. However, the relationship between RRP9 and DDX21 and colorectal cancer (CRC) remains unclear. GSE134834, GSE206800, and GSE209892 profiles for CRC were downloaded from the gene expression omnibus database generated using GPL20115 and GPL23126. Differentially expressed genes (DEGs) were screened and weighted gene co-expression network analysis was performed. The construction and analysis of protein–protein interaction network. Functional enrichment analysis and gene set enrichment analysis were performed. Gene expression heat map was drawn and immune infiltration analysis was performed. Comparative toxicogenomics database analysis were performed to find the disease most related to the core gene. TargetScan was used to screen miRNAs regulating central DEGs. One thousand three hundred eighty DEGs were identified. According to gene ontology analysis, they were mainly concentrated in signal receptor activity regulation and metal titanase activity. Kyoto encyclopedia of gene and genome analysis showed that they mainly focused on IL17 signal pathway, PPAR signal pathway, protein digestion, and absorption, and the interaction of viral proteins with cytokines and cytokine receptors. The intersection of enrichment items and GOKEGG enrichment items of differentially expressed genes is mainly concentrated in PPAR signal pathway and the interaction of viral proteins with cytokines and cytokine receptors. The protein–protein interaction network obtained 16 core genes (MAD2L1, MELK, TPX2, UBE2C, RFC4, PLK1, RACGAP1, DKC1, DDX21, L Y AR, WDR3, RRP9, WDR43, NOLC1, BRIX1, and GTPBP4). Heat map of gene expression showed that core genes (TPX2, UBE2C, RFC4, PLK1, DKC1, LYAR, WDR3, NOLC1, and BRIX1) were not significantly differentially expressed between CRC and normal tissue samples. Core genes (MAD2L1, MELK, RACGAP1, RRP9, WDR43, DDX21, and GTPBP4) were highly expressed in CRC tissue samples and lowly expressed in normal tissue samples. Comparative toxicogenomics database analysis showed that 7 genes (MAD2L1, MELK, RACGAP1, RRP9, WDR43, DDX21, and GTPBP4) were related to necrosis, inflammation, tumor, precancerous symptoms, hemorrhage, and weightlessness. RRP9 and DDX21 are highly expressed in CRC. The higher the expression level of RRP9 and DDX21, the worse the prognosis.