Miracle-dz/UniFAR-FTUs huggingface dataset:
Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies

Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies.
An experimental study on the determination of dispersion coefficient in layered soils

Dispersivity is a measurable parameter in soil porous media that is used for studying the transport of contaminants to groundwater. The value of this parameter depends on various factors, including the kind of porous media (homogeneous or heterogeneous), flow velocity, initial contaminant concentration, travel distance, and sampling method. A physical model with dimensions of 0.10 m in width, 0.80 m in height, and 1.10 m in length was constructed to investigate the effects of these parameters on the dispersivity value. The stratified soil consisted of three 20-cm-thick layers containing fine-grained, medium-grained, and coarse-grained soil. Sodium chloride solutions with electrical conductivity values of 10, 14, and 19 dS/m were used as the contaminants. Flow was forced through the layered heterogeneous soils at three discharge velocities of 17.58, 22.02, and 26.18 × 10−5 m/s. The point and mixed sampling methods were used. The results indicated that the soil dispersivity values in the layered heterogeneous soils and homogeneous soil were influenced by contaminant concentration, flow velocity, and travel distance. Moreover, the dispersivity values obtained by point sampling were lower than those obtained using the mixed sampling method, and the mean dispersivity value in the layered heterogeneous soils was lower than that of the homogeneous soil.
Development of an Online Asynchronous Clinical Learning Resource (“Ask the Expert”) in Dental Education to Promote Personalized Learning

This article describes the development and testing of an online asynchronous clinical learning resource named “Ask the Expert” to enhance clinical learning in dentistry. After the resource development, dental students from years 3 and 4 were randomly allocated to two groups (Group A—“Ask the Expert” and L—“lecturer-led”). All the students attempted a pre-test related to replacement of teeth in the anterior aesthetic zone. Group A (33 students) underwent an online case-based learning session of 60 minutes’ duration without a facilitator, while Group L (27 students) concurrently underwent a case-based learning session of 60 minutes’ duration with a lecturer facilitating the session. An immediate post-test was conducted followed by a retention test after one week. Student feedback was obtained. There was a significant increase in the test scores (maximum score 10) for both groups when comparing the pre-test (Group A—5.61 ± 1.34, Group L—5.22 ± 1.57) and immediate post-test scores (Group A—7.42 ± 1.34, Group L—8.04 ± 1.22; paired t-test, p < 0.001). However, no significant difference was observed in the test scores when comparing Group A to Group L for both the immediate post-test as well as the retention test (Group A—5.36 ± 1.29, Group L—5.33 ± 1.39 (independent sample t-test, p > 0.05). To conclude, adequately structured online asynchronous learning resources are comparable in their effectiveness to online synchronous learning in the undergraduate dental curriculum.
Shenjinhuoxue Mixture Attenuates Inflammation, Pain, and Cartilage Degeneration by Inhibiting TLR-4 and NF-κB Activation in Rats with Osteoarthritis: A Synergistic Combination of Multitarget Active Phytochemicals

Osteoarthritis (OA), a highly prevalent chronic joint disease, involves a complex network of inflammatory mediators that not only triggers pain and cartilage degeneration but also accelerates disease progression. Traditional Chinese medicinal shenjinhuoxue mixture (SHM) shows anti-inflammatory and analgesic effects against OA with remarkable clinical efficacy. This study explored the mechanism underlying anti-OA properties of SHM and evaluated its efficacy and safety via in vivo experiments. Through network pharmacology and published literature, we identified the key active phytochemicals in SHM, including β-sitosterol, oleanolic acid, licochalcone A, quercetin, isorhamnetin, kaempferol, morusin, lupeol, and pinocembrin; the pivotal targets of which are TLR-4 and NF-κB, eliciting anti-OA activity. These phytochemicals can enter the active pockets of TLR-4 and NF-κB with docking score ≤ −3.86 kcal/mol, as shown in molecular docking models. By using surface plasmon resonance assay, licochalcone A and oleanolic acid were found to have good TLR-4-binding affinity. In OA rats, oral SHM at mid and high doses (8.72 g/kg and 26.2 g/kg) over 6 weeks significantly alleviated mechanical and thermal hyperalgesia (P < 0.0001). Accordingly, the expression of inflammatory mediators (TLR-4, interleukin (IL-) 1 receptor-associated kinase 1 (IRAK1), NF-κB-p65, tumor necrosis factor (TNF-) α, IL-6, and IL-1β), receptor activator of the NF-κB ligand (RANKL), and transient receptor potential vanilloid 1 (TRPV1) in the synovial and cartilage tissue of OA rats was significantly decreased (P < 0.05). Moreover, pathological observation illustrated amelioration of cartilage degeneration and joint injury. In chronic toxicity experiment of rats, SHM at 60 mg/kg demonstrated the safety. SHM had an anti-inflammatory effect through a synergistic combination of active phytochemicals to attenuate pain and cartilage degeneration by inhibiting TLR-4 and NF-κB activation. This study provided the experimental foundation for the development of SHM into a more effective dosage form or new drugs for OA treatment.
Cervical cancer situation in Malaysia: A systematic literature review

Cervix cancer is one of Malaysia’s most significant cancers for women (around 12.9%, with an age-standardised incidence rate of 19.7 per 100,000). It was higher than other Asian, West, and even worldwide nations. The National Strategic Plan for Cancer Control Program 2016–2020 (Health Ministry) was presented to minimize cancer and mortality. The high incidence of cervical cancer in Malaysia is mainly due to women’s insufficient knowledge about its prevention and importance. Compared with traditional literature reviews, the systemic analysis provides many advantages. A clearer review process, a more prominent field of study, and essential priorities that can manage research bias can all help to enhance these reviews. However, better integration, cooperation, and coordination between government and private sector as well as NGOs and professional organisations are essential for optimal cancer control and treatment across the country.
Urban Energy Transitions in Europe, towards Low-Socio-Environmental Impact Cities

Achieving the ambitious targets set by Europe in its 2050 roadmap, moving away from fossil fuels towards renewable energy sources, while reducing carbon emissions, will require a radical change in Europe’s energy system. Much of the action that will enable this energy transition to be realised in a democratic way is at the local level. It is at this level that many of the decisions regarding the energy transition desired by European citizens will have to be taken. The methodology used in this study is based on data collection, literature review, data validation and analysis. A part of this analysis will also be taken by the mPower project as a diagnostic baseline. The first finding of this research work is that energy transition data availability at the local level is quite low. Second, the local authorities are experiencing difficulties in decarbonising their energy consumption. Finally, the factor with highest positive relationships with other energy transition variables is the number of people employed in the field of energy transition. The results suggest that in order to lead a participatory energy transition, the workforce specifically dedicated to energy transition is a key factor, clearly differentiating it from staff working on the general energy field.
Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug

Materials based on calcium carbonate (CaCO3) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO3 and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO3 (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug: DOXorubicin (DOX). We also showed a prolonged pH-dependent release of DOX from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO3-and-DOX–based composite (CaNP7-DOX) in in vitro models.
DOT1L bridges transcription and heterochromatin formation at pericentromeres

Repetitive DNA elements are packaged in heterochromatin, but many require bursts of transcription to initiate and maintain long-term silencing. The mechanisms by which these heterochromatic genome features are transcribed remain largely unknown. Here, we show that DOT1L, a conserved histone methyltransferase that modifies lysine 79 of histone H3 (H3K79), has a specialized role in transcription of major satellite repeats to maintain pericentromeric heterochromatin and genome stability. We discover that H3K79me3 is enriched at repetitive elements, that DOT1L loss specifically compromises pericentromeric satellite transcription, and that this function depends on interaction between DOT1L and the chromatin remodeler SMARCA5. Activation of pericentromeric repeats by DOT1L drives the first establishment of heterochromatin structures in cleavage-stage embryos and is required for preimplantation viability. Our findings uncover a vital instructive role for DOT1L as a bridge between transcriptional activation of heterochromatic repeats and maintenance of genome integrity, and illuminate global chromatin dynamics during early development.
Pathogens isolated from bovine clinical mastitis and their antimicrobial resistance

This study aimed to isolate aerobic and microaerophilic bacteria from mastitis milk samples, as well as to determine their antibiotic resistance. A total of 196 bovine mastitis milk samples were tested by standard bacteriological methods and with API identification test kits. Antimicrobial susceptibility testing was performed by the Kirby-Bauer disk diffusion method. The results revealed that the predominant isolate was S. aureus, with an isolation rate of 28%, followed by Streptococcus spp. (27%) and E. coli (19%). Isolation rates for Corynebacterium spp. , Mycoplasma spp. , and Pseudomonas aeruginosa were 11%, 6%, and 4%, respectively. Compared to the bacteria mentioned above, lower percentages were observed for Trueperella pyogenes (2%), Pasteurella multocida (2%), and Klebsiella pneumoniae (1%). A broad evaluation of antimicrobial resistance showed that the pathogens were resistant to tetracycline (68.63%), oxytetracycline (41.57%), ampicillin (39.08%), ceftiofur (38.1%), cephalexin (32.26%), penicillin (31.25%), amoxicillin/clavulanic acid (24.53%), enrofloxacin (24.44%), gentamycin (23.68%), and trimethoprim/sulfamethoxazole (22.09%). This study demonstrated that the sources of bacteria isolated from mastitis bovine milk samples were both contagious and environmental. More importantly, the present results demonstrate a critically high antimicrobial resistance in dairy cattle. For instance, E. coli isolates showed a crucial resistance to commonly used and recommended antimicrobials, including ceftiofur (100%), cephalexin (83.33%), and tetracycline (94.44%). The results of this study may provide valuable information about clinical aspects of bovine mastitis infections and current antimicrobial resistance levels in dairy cattle.
Effects of Forkhead box O1 on lipopolysaccharide-induced mitochondrial dysfunction in human cervical squamous carcinoma SiHa cells

Persistent infection and chronic inflammation play important roles in the development of cervical squamous cell carcinoma. Forkhead box O1 (FOXO1) is a notable regulator of mitochondrial metabolism, which is involved in the occurrence and development of tumors. The present study explored the effects of FOXO1 in human cervical squamous carcinoma SiHa cells. The expression of FOXO1 was examined using reverse transcription-quantitative PCR, western blotting and immunohistochemical staining. SiHa cell migration and proliferation were detected using Transwell and 3H-TdR assays. Mitochondrial functions were assessed based on reactive oxygen species (ROS) generation and changes in the mitochondrial membrane potential (ΔΨm). The present study revealed that lipopolysaccharide (LPS) stimulation significantly inhibited the expression of FOXO1 in cervical squamous carcinoma SiHa cells; while silencing FOXO1 resulted in the accumulation of mitochondrial ROS, a decrease in the ΔΨm and abnormal morphology of mitochondria. Accordingly, enhancing FOXO1 expression or treatment with metformin, which protects mitochondrial function, reversed LPS-induced mitochondrial dysfunction, cell pyroptosis, migration and proliferation of cervical squamous carcinoma SiHa cells. Overall, the current study indicated that treatment with FOXO1 could potentially be used as therapeutic strategy to prevent LPS-induced cervical squamous cell carcinoma-related dysfunction in a mitochondria-dependent manner.
Comparison Study on the Performance of a Novel and Traditional Energy Piles by Laboratory Tests

Phase change material (PCM) is a substance that can absorb or release sufficient latent heat at phase transition. By encapsulating phase change paraffin in hollow steel balls in the concrete, an energy pile with PCM was innovatively produced to improve energy efficiency for the ground heat pumping system. Laboratory tests were carried out on both PCM energy pile and traditional concrete pile to evaluate the thermo mechanical performance. Two piles were heated and cooled through inside tubes at a constant flow rate. The laboratory tests on the two piles were symmetrical for the two horizontal directions in geometry, and heat transfer process follows conservation laws of energy. The temperature response of the pile and soil, internal strain, pile displacement, pore pressure, and soil pressure under heating-cooling cycles were examined. Compared with the traditional concrete pile, the PCM energy pile can effectively reduce the surrounding soil temperature. The use of PCM in the pile can improve the capacity of heat storage and make the pile more effective in heat exchange. Non-uniform thermal strain and accumulations of heat and irrecoverable displacement were observed in the repeated heating-cooling process. The study can provide references for the practical implication of PCM energy piles.
Experiences of influencing one's own life when living with working-age dementia

Abstract Having opportunities to make decisions and choices regarding one's life is crucial when living with dementia. This inter-disciplinary study draws on the concept of relational autonomy to explore how working-age people living dementia seek to influence their lives, and what makes it easier or more difficult for them in their everyday life. The data consist of three focus group discussions conducted with 12 retired adults who developed dementia while still employed. The results illuminate various resources that enable a person to (a) handle their difficulties at work and related consequences with dignity, (b) manage everyday tasks and live a fulfilling life, and (c) fight the stigma associated with (working-age) dementia. Challenges related to these aspects reported by the participants reveal gaps and obstacles that impede the full realisation of the rights of people living with early onset dementia. This research highlights the need for workplace education for different stakeholders, equal and ongoing access to guidance and counselling for younger people who live with dementia, and an effort by society as a whole to eradicate stigma.
Understanding the impact of influencers’ responses to negative follower comments on the persuasiveness of sponsored Instagram posts

Abstract While social media influencers have been enjoying increasing accolades from followers and brands, they also suffer from criticisms or harassments from some followers. Extant research has not yet examined the efficacy of response strategies adopted by influencers when addressing negative comments. This study is to fill the research gap. An online experiment has been conducted among followers of an actual influencer to examine how influencers’ response strategies (i.e. defensive vs. accommodative) to followers’ negative comments (i.e. an objective complaint of product failure vs. a subjective dislike) affect the persuasiveness of influencer-sponsored content. The results of this study reveal that a defensive response harms influencer trustworthiness more than an accommodative response when it concerns a subjective disliking of the endorsed product. This lowered trustworthiness further leads to followers’ decreased perceived product quality and less favourable brand attitudes. When it concerns an objective comment on product failure, an influencer’s defensive response does not differ from accommodative response in affecting influencer trustworthiness. These findings indicate that an accommodative strategy may be an efficient way to cope with a negative follower comment, especially in case of a subjective product disliking.
A self‐learning artificial bee colony algorithm based on reinforcement learning for a flexible job‐shop scheduling problem

The flexible job‐shop scheduling problem (FJSP) is currently one of the most critical issues in process planning and manufacturing. The FJSP is studied with the goal of achieving the shortest makespan. Recently, some intelligent optimization algorithms have been applied to solve FJSP, but the key parameters of intelligent optimization algorithms cannot be dynamically adjusted during the solution process. Thus, the solutions cannot best meet the needs of production. To solve the problems of slow convergence speed and reaching a local optimum with the artificial bee colony (ABC) algorithm, an improved self‐learning artificial bee colony algorithm (SLABC) based on reinforcement learning (RL) is proposed. In the SLABC algorithm, the number of updated dimensions of the ABC algorithm can be intelligently selected according to the RL algorithm, which improves the convergence speed and accuracy. In addition, a self‐learning model of the SLABC algorithm is constructed and analyzed using Q‐learning as the learning method of the algorithm, and the state determination and reward methods of the RL algorithm are designed and included in the environment of the artificial bee colony algorithm. Finally, this article verifies that SLABC has excellent convergence speed and accuracy in solving FJSP through Brandimarte instances.
COVID-19 and Romantic Relationships

Since the beginning of 2020, the COVID-19 pandemic has impacted most people’s activities and relationships. Romantic relationships are a crucial source of fulfillment and emotional safety for many individuals. However, due to the risk of illness and the social distancing norms, human interaction, even inside one’s couple or family, suffered great changes. Some of these changes have the potential of disrupting people’s relational or psychological well-being, but they can also have positive impacts. On the other hand, one of the most negative consequences is the growing number of intimate partner violence (IPV) incidents. Considering all these aspects, therapy would be beneficial for those affected.
Employment Prospects of Humanitarian Migrants in Australia: Does Gender Inequality in the Origin Country Matter?

Abstract Despite a steady inflow of humanitarian migrants to Australia, their socio-economic outcomes remain visibly poorer than those of other migrants and the general population. Therefore, understanding the factors contributing to refugee integration is an important endeavor. In this paper, we focus on refugees’ labor-market outcomes and the role of a potentially important macro-level factor: gender inequality in the origin country. To accomplish this, we leverage high-quality longitudinal data from a probability survey (Building a New Life in Australia, n = 9,268) augmented with country-level data from the UNDP. Our results bear implications for gender and migration scholarship, and equity policy and practice.
NRC Publications Archive Archives des publications du CNRC

Digital twin (DT) has gained success in various industries, and it is now getting attention in the healthcare industry in the form of well-being digital twin (WDT). In this paper, we present an overview of WDT to understand its potential scope, architecture and impact. We then discuss the definition and the benefits of WDT. After that, we present the evolution of DT frameworks. Subsequently we discuss the challenges, the different types, the drawbacks, and potential application areas of WDT. Finally we present the requirements for a WDT framework extracted from the literature.
Multilayer Films Based on Poly(lactic acid)/Gelatin Supplemented with Cellulose Nanocrystals and Antioxidant Extract from Almond Shell By-Product and Its Application on Hass Avocado Preservation

In this work, poly(lactic acid) (PLA)/gelatin/PLA multilayer films supplemented with cellulose nanocrystals and antioxidant extract from almond shell (AS) by-products were developed by solvent casting technique for active food packaging. The almond shell antioxidant extract (ASE) was obtained by microwave-assisted extraction, while cellulose nanocrystals (CNCs) were extracted from AS by a sequential process of alkalization, acetylation and acid hydrolysis. Four formulations were obtained by adding 0 (control), 6 wt. % of ASE (FG/ASE), 4.5 wt. % of CNCs (FG/CNC) and 6 wt. % + 4.5 wt. % of ASE + CNCs, respectively, (FG/ASE + CNC) into fish gelatin (FG). PLA/FG/PLA multilayer films were prepared by stacking two outer PLA layers into a middle FG film. A surface modification of PLA by air atmospheric plasma treatment was optimized before multilayer development to improve PLA adhesion. Complete characterization of the multilayers underlined the FG/ASE + CNC formulation as a promising active reinforced packaging system for food preservation, with low values of transparency, lightness and whiteness index. A good adhesion and homogeneity of the multilayer system was obtained by SEM, and they also demonstrated low oxygen permeability (40.87 ± 5.20 cm3 mm m−2 day) and solubility (39.19 ± 0.16%) values, while mechanical properties were comparable with commercial plastic films. The developed multilayer films were applied to Hass avocado preservation. The initial degradation temperature (Tini), DSC parameters and in vitro antioxidant capacity of the films were in accordance with the low peroxide and anisidine values obtained from avocado pulp after packaging for 14 days at 4 °C. The developed PLA/FG/PLA films supplemented with 6 wt. % ASE+ 4.5 wt. % CNCs may be potential bioactive packaging systems for fat food preservation.