Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors influencing post-screening visits of students to local vision centres in rural northwest China

ABSTRACT Clinical relevance Children with uncorrected visual impairment have lower scores on a variety of motor and cognitive tests. Exploring the influencing factors of low-income groups seeking vision care services is helpful for identifying relevant barriers and necessary measures to improve the utilization rate of vision care services. Background The community-based vision center (VC) is a popular model for solving vision problem of students in rural China. Compliance is the key factor to the success of the VC model. Factors determining compliance with visitations to VC among primary school students after screening were explored. Methods A cross-sectional study was conducted with 15,763 students from 228 primary schools. Information was collected through questionnaires and vision examinations. The determinants that affect visits of students to the VC were analyzed using logistic regression. Results Among the 15,763 sample, 5,361 (34%) students had a visual impairment. At baseline, only 962 (18%) of students with visual impairment sought vision care services. After a local VC was established, among the 5,163 students who needed to be referred, only 2,237 (43.33%) students visited the VC. Multivariate logistic regression models for predicting students visit the VC revealed that the following characteristics were significant predictors: poor uncorrected visual acuity (P < 0.001), a higher grade level (P = 0.008; P = 0.010), ‘left-behind’ children (P < 0.001), short living distance between home and the VC (P < 0.001), and the fact that these students lived in Gansu province (P < 0.001). Conclusions Establishing a VC that provides students with vision screening and free vision care services can increase the rate of seeking vision health services for students in rural areas, but the compliance rate still needs to be improved. The influencing factors for student compliance have been identified.
The psychological health of patients diagnosed with cancer in Iraq during the COVID‐19 pandemic: A single center study

The objective of this study was to assess the psychological health status of patients diagnosed with cancer in Iraq during the COVID‐19 pandemic. The study aim was to measure the prevalence of depression, anxiety, and stress among patients diagnosed with cancer. Secondary aims were to assess the association between depression, anxiety, and stress with sociodemographic characteristics, cancer‐specific characteristics, patients' experience in healthcare visit, risk perception towards COVID‐19, and health concern during the outbreak.
The prevalence of urinary incontinence in obese women and its effect on quality of life

ABSTRACT This is an analytical cross-sectional study conducted to investigate the incidence of urinary incontinence in obese women and its effect on quality of life. The mean BMI of the obese women participating in the study was 37.34 ± 4.85 and 88.1% of them had urinary incontinence. The I-QOL score was 63 (min; max: 25; 108) in the women found to have urinary incontinence. According to the ICIQ-SF scores obtained, urinary incontinence was higher than the disturbing level.
Beta-rich intermediates in denaturation of lysozyme: accelerated molecular dynamics simulations

Abstract Amyloid fibrillar aggregates play a critical role in many neurodegenerative disorders. Conversion of globular proteins into fibrils is associated with global conformational rearrangement and involves the transformation of α-helices to β-sheets. In the present work, the accelerated molecular dynamics technique was applied to study the unfolding of hen egg-white lysozyme at elevated temperatures, and the transformation of the native structure to a disordered one was analyzed. The influence of the disulfide bonds on the conformational dynamics and the energy landscape of denaturation process was considered. Our results show that formation of the metastable β-enriched conformers of individual protein molecules may precede the aggregation process. These β-rich intermediates can play a role of bricks making up fibrils. Communicated by Ramaswamy H. Sarma
Protective antigenic sites identified in respiratory syncytial virus fusion protein reveals importance of p27 domain

Respiratory syncytial virus (RSV) vaccines primarily focused on surface fusion (F) protein are under development. Therefore, to identify RSV‐F protective epitopes, we evaluated 14 antigenic sites recognized following primary human RSV infection. BALB/c mice were vaccinated with F peptides, F proteins, or RSV‐A2, followed by rA2‐Line19F challenge. F peptides generated binding antibodies with minimal in vitro neutralization titers. However, several F peptides (including Site II) reduced lung viral loads and lung pathology scores in animals, suggesting partial protection from RSV disease. Interestingly, animals vaccinated with peptides (aa 101–121 and 110–136) spanning the F‐p27 sequence, which is only present in unprocessed F0 protein, showed control of viral loads with significantly reduced pathology compared with mock‐vaccinated controls. Furthermore, we observed F‐p27 expression on the surface of RSV‐infected cells as well as lungs from RSV‐infected mice. The anti‐p27 antibodies demonstrated antibody‐dependent cellular cytotoxicity (ADCC) of RSV‐infected A549 cells. These findings suggest that p27‐mediated immune response may play a role in control of RSV disease in vivo, and F‐p27 should be considered for inclusion in an effective RSV vaccine.
Diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging for distinguishing pseudoprogression from glioma recurrence: a meta-analysis

Abstract Background: It is crucial to differentiate accurately glioma recurrence and pseudoprogression which have entirely different prognosis and require different treatment strategies. This study aimed to assess the diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as a tool for distinguishing glioma recurrence and pseudoprogression. Methods: According to particular criteria of inclusion and exclusion, related studies up to May 1, 2019, were thoroughly searched from several databases including PubMed, Embase, Cochrane Library, and Chinese biomedical databases. The quality assessment of diagnostic accuracy studies was applied to evaluate the quality of the included studies. By using the “mada” package in R, the heterogeneity, overall sensitivity, specificity, and diagnostic odds ratio were calculated. Moreover, funnel plots were used to visualize and estimate the publication bias in this study. The area under the summary receiver operating characteristic (SROC) curve was computed to display the diagnostic efficiency of DCE-MRI. Results: In the present meta-analysis, a total of 11 studies covering 616 patients were included. The results showed that the pooled sensitivity, specificity, and diagnostic odds ratio were 0.792 (95% confidence interval [CI] 0.707–0.857), 0.779 (95% CI 0.715–0.832), and 16.219 (97.5% CI 9.123–28.833), respectively. The value of the area under the SROC curve was 0.846. In addition, the SROC curve showed high sensitivities (>0.6) and low false positive rates (<0.5) from most of the included studies, which suggest that the results of our study were reliable. Furthermore, the funnel plot suggested the existence of publication bias. Conclusions: While the DCE-MRI is not the perfect diagnostic tool for distinguishing glioma recurrence and pseudoprogression, it was capable of improving diagnostic accuracy. Hence, further investigations combining DCE-MRI with other imaging modalities are required to establish an efficient diagnostic method for glioma patients.
The biomechanistic aspects of renal cortical injury induced by diesel exhaust particles in rats and the renoprotective contribution of quercetin pretreatment: Histological and biochemical study

Although several studies have reported a toxic effect of diesel exhaust particles (DEP) exposure on the kidney tissues, the involvement of autophagy/NF‐kB signaling as encountered mechanisms and the protective effects of a natural flavonoid, quercetin on DEP remains unclear. Thirty‐two albino rats were divided as control, quercetin‐treated (60 mg/kg, oral), DEP‐exposed (0.5 mg/kg, intra‐tracheal), and quercetin/DEP‐exposed groups. Specimens of the renal cortex were subjected to histo‐biochemical study and immunohistochemical analysis using anti‐NF‐kB, and anti‐LC3β antibodies followed by morphometric and statistical analyses. The expression level of autophagy genes was quantitatively evaluated using RT‐PCR, as well. The DEP‐exposed rats showed an elevation in the renal tissue levels of MDA and a decrease in the catalase and superoxide dismutase (p < .05). Histologically, there were cytoplasmic vacuolar changes in the lining cells of the renal tubules, glomerular atrophy, and vascular congestion. In addition, renal inflammation was evident as confirmed by the increased NF‐kB immunoexpression. Moreover, the gene expression of Becn1, ATG5, and LC3β increased (p <. 0) due to DEP exposure. Conversely, quercetin pretreatment improved these renal histo‐biochemical alterations (p < .05) and regulated autophagy/NF‐kB pathways. Overall, the study proved the renal toxicity mediated by DEP exposure via precipitating renal inflammation, autophagy activation, and oxidative stress. Quercetin pretreatment could antagonize such machinery to protect the kidney against DEP.
Prone position in COVID 19-associated acute respiratory failure

Supplemental Digital Content is available in the text Purpose of review Prone position has been widely used in the COVID-19 pandemic, with an extension of its use in patients with spontaneous breathing (’awake prone’). We herein propose a review of the current literature on prone position in mechanical ventilation and while spontaneous breathing in patients with COVID-19 pneumonia or COVID-19 ARDS. Recent findings A literature search retrieved 70 studies separating whether patient was intubated (24 studies) or nonintubated (46 studies). The outcomes analyzed were intubation rate, mortality and respiratory response to prone. In nonintubated patient receiving prone position, the main finding was mortality reduction in ICU and outside ICU setting. Summary The final results of the several randomized control trials completed or ongoing are needed to confirm the trend of these results. In intubated patients, observational studies showed that responders to prone in terms of oxygenation had a better survival than nonresponders.
MiR-582-5p attenuates neonatal hypoxic-ischemic encephalopathy by targeting high mobility group box 1 (HMGB1) through inhibiting neuroinflammation and oxidative stress.

BACKGROUND MiR-582-5p has been demonstrated to protect against ischemic stroke. However, its implication in the progression of neonatal hypoxic-ischemic encephalopathy (HIE) has not been explored. METHODS In this study, we used an in vitro model of oxygen-glucose deprivation (OGD) to investigate the protective effect of miR-582-5p on PC12 cells. OGD-induced inhibition of cell viability and promotion of cell death was assessed by CCK-8 assay and flow cytometry. Real-time PCR and enzyme-linked immunosorbent assay (ELISA) were utilized to examine the levels of inflammatory cytokines. The effects of miR-582-5p on OGD-induced oxidative injury were assessed by the determination of oxidative stress indicators. Furthermore, dual-luciferase reporter assay and gain-offunction assay were used to determine the mechanism of miR-582-5p in OGD-induced cell injury. RESULTS The expression of miR-582-5p was reduced upon OGD treatment in PC12 cells. Overexpression of miR-582-5p inhibited OGD-induced PC12 cell injury by regulating cell viability, apoptosis, inflammatory responses, and oxidative stress. MiR-582-5p targeted and negatively regulated high mobility group box 1 (HMGB1). MiR-582-5p presented protective effects on OGD-induced PC12 cell injury by targeting HMGB1. CONCLUSION Our results indicated that miR-582-5p ameliorates neuronal injury by inhibiting apoptosis, inflammation, and oxidative stress through targeting HMGB1.
Computational and Experimental Analysis of Direct CNG Injection and Mixture Formation in a Spark Ignition Research Engine

Direct injection (DI) of compressed natural gas (CNG) under high pressure conditions is a topic of great interest, owing to its potential for improving SI engine performance and fuel consumption. However, relevant technical difficulties have yet to be resolved in order to stabilize combustion process, especially for stratified engine operating conditions. The present paper is focused on experimental and numerical investigations of the jet formation and fuel-air mixing process in a research optical-access single-cylinder engine. The engine is based on the multi-cylinder engine under development within the European Community (EC) VII Framework Program (FP) InGAS Integrated Project, and features a centrally mounted poppet-valve injector on a pent-roof combustion chamber with a bowl in piston. Experimental investigations were made by means of the planar laser-induced fluorescence technique, and revealed a cycle-to-cycle jet shape variability. In particular, for specific cylinder pressure values at the start of injection, the jet can adhere to chamber walls for a relevant number of cycles, leading to an ‘umbrella-like’ shape. This can change the mixing capabilities of the combustion chamber and cause instabilities in the combustion process. The mentioned behaviour is strongly dependent not only on the injection and cylinder pressures, but also on important design parameters, such as needle cone angle and in-chamber injector protrusion. For this reason, in order to obtain a deep insight into the injected gas behaviour on an average cycle basis, the experimental investigation was supported by a numerical analysis. Simulations were carried out by an optimized variable-density finite-volume numerical model which was built within the Star-CD environment. A previously developed and validated ‘virtual injector’ model was implemented. The outcomes of the numerical model were compared to laser-induced fluorescence images, for both stratified- and homogeneous-charge engine operating conditions and a good agreement was obtained, substantiating the reliability of the applied computational model. Then, the effects of the injector protrusion in the combustion chamber and of injection timing were analyzed, and their impact on jet stability and mixture-formation process was analyzed.Copyright © 2010 by ASME
Circulating microRNAs as indicators in the prediction of neoadjuvant chemotherapy response in luminal B breast cancer

Circulating microRNAs (miRNAs) have been indicated as predictive biomarker for the response to neoadjuvant chemotherapy (NAC) and the prognosis of breast cancer (BC); however, to date the conclusions have been controversial. The biological characteristics of BC were affected by molecular subtypes. Hence, we aimed to investigate the predictive effect of miRNAs on NAC response in luminal B BC patients.
Fetal Hemodynamic Response to Anemia in Early Gestation: Using Hemoglobin Bart’s Disease as a Study Model

Abstract Objective To assess fetal hemodynamic changes in response to anemia in early gestation, using fetal Hb Bart’s disease as a study model. Methods A prospective study was conducted on pregnancies at risk for fetal Hb Bart’s disease at 12–14 weeks of gestation. Fetal hemodynamics were comprehensively assessed by 2D ultrasound, Doppler velocity, and cardio-STIC just prior to the invasive procedure for diagnosis. The various hemodynamic parameters of the affected and unaffected fetuses were compared. Results Of 56 fetuses at risk, 17 had Hb Bart’s disease and 39 were unaffected. The right and combined ventricular cardiac outputs (CO) were significantly higher in the affected fetuses (0.993 vs. 1.358; p < 0.001 and 1.010 vs. 1.236; p < 0.001, respectively), whereas the left CO tended to be higher but not significantly (1.027 vs. 1.113; p = 0.058). Cardiac dimensions, middle-cerebral artery peak systolic velocity, Tei index, and isovolemic contraction time were significantly increased, while the global sphericity index was significantly decreased. Interestingly, cardiac preload, ventricular wall thickness, shortening fraction, isovolemic relaxation time, and fetal heart rate were unchanged. Four fetuses had hydropic changes, but all cardiac functions were normal. Conclusion Fetal anemia induces hypervolemia and increases cardiac output to meet the tissue oxygen requirement, resulting in an increase in size without hypertrophy, volume load without pressure load, and a decrease in the globular sphericity index. The heart works very well but works harder, especially systolic ventricular load. Hydrops fetalis due to anemia appears not to be caused by heart failure as previously believed but rather by volume load with high vascular permeability at least in early pregnancy.
Implicit bias predicts less willingness and less frequent adoption of Black children more than explicit bias

ABSTRACT In the United States, prospective adoptive parents often express preferences related to race. In two studies, we examined whether implicit racial bias against Black people may contribute to disparities in much less willingness to adopt Black children. The first study (N = 510) assessed individuals’ implicit racial bias and their willingness to adopt a Black child. The second study (N = 2,001,652) used U.S. state-level implicit racial bias to predict adoption rates of Black foster children in each U.S. state. Greater implicit racial bias predicted less willingness to adopt Black children and less frequent adoptions of Black foster children. Implicit bias contributed to these disparities above and beyond explicit bias, with implicit bias having a 43% larger effect size than explicit bias on willingness to adopt a Black child. These are the first findings to demonstrate the role implicit bias plays in explaining large disparities between Americans’ willingness to adopt Black and White children.
AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology

Skeletomuscular diseases result in significant muscle loss and decreased performance, paralleled by a loss in mitochondrial and oxidative capacity. Insulin and insulin‐like growth factor‐1 (IGF‐1) are two potent anabolic hormones that activate a host of signalling intermediates including the serine/threonine kinase AKT to influence skeletal muscle physiology. Defective AKT signalling is associated with muscle pathology, including cachexia, sarcopenia, and disuse; however, the mechanistic underpinnings remain unresolved.
Comparison of Distributions of Wave Heights From Nonlinear Schröedinger Equation Simulations and Laboratory Experiments

Numerical simulations of the nonlinear Schrodinger (NLS) equation are performed by imposing randomly synthesized free surface displacement at the wave maker characterized by the Joint North Sea Wave Project (JONSWAP) spectrum and compared with four different sea states generated in the deepwater wave basin of Marintek. The comparisons show that the numerical simulations have a high degree of agreement with the laboratory experiments although a little overestimation can be observed, especially in the severe sea state. Thus, the simulations still catch the main characteristics of extreme waves and provide an important physical insight into their generation. The coefficient of kurtosis λ40 presents a similar spatial evolution trend with the abnormal wave density, and the nonlinear Gram–Charlier (GC) model is used to predict the wave height distribution. It is demonstrated again that the theoretical approximation based on the GC expansion can describe large wave heights reasonably well in most cases. However, if the sea state is severe, wave breaking can significantly decrease the actual tail of wave height distribution, and discrepancy occurs when comparing with the numerical simulation. Moreover, the number of waves also plays an important role on the prediction of extreme wave height.
Comparing information diffusion mechanisms by matching on cascade size

Significance Do different types of information spread differently online? In recent years, studies have sought answers to such questions by comparing statistical properties of network paths taken by different kinds of content diffusing online. Here, we demonstrate the importance of controlling for correlations between properties being compared. In particular, we show that previously reported structural differences between diffusion paths of false and true news on Twitter disappear when comparing only cascades of the same size; differences between diffusion paths of images, videos, news, and petitions persist. Paired with a theoretical analysis of diffusion processes, our results suggest that, in order to limit the spread of false news, it may be enough to focus on reducing the mean “infectiousness” of the information. Do some types of information spread faster, broader, or further than others? To understand how information diffusions differ, scholars compare structural properties of the paths taken by content as it spreads through a network, studying so-called cascades. Commonly studied cascade properties include the reach, depth, breadth, and speed of propagation. Drawing conclusions from statistical differences in these properties can be challenging, as many properties are dependent. In this work, we demonstrate the essentiality of controlling for cascade sizes when studying structural differences between collections of cascades. We first revisit two datasets from notable recent studies of online diffusion that reported content-specific differences in cascade topology: an exhaustive corpus of Twitter cascades for verified true- or false-news content by Vosoughi et al. [S. Vosoughi, D. Roy, S. Aral. Science 359, 1146–1151 (2018)] and a comparison of Twitter cascades of videos, pictures, news, and petitions by Goel et al. [S. Goel, A. Anderson, J. Hofman, D. J. Watts. Manage. Sci. 62, 180–196 (2016)]. Using methods that control for joint cascade statistics, we find that for false- and true-news cascades, the reported structural differences can almost entirely be explained by false-news cascades being larger. For videos, images, news, and petitions, structural differences persist when controlling for size. Studying classical models of diffusion, we then give conditions under which differences in structural properties under different models do or do not reduce to differences in size. Our findings are consistent with the mechanisms underlying true- and false-news diffusion being quite similar, differing primarily in the basic infectiousness of their spreading process.
Simulations of Three-Dimensional Vertical-Axis Turbines for Communications Applications

A numerical simulation has been performed to assist in evaluating vertical-axis Savonius-style wind turbines. The simulation was fully three-dimensional and unsteady. Through the simulation, it was possible to assess the performance of a wind turbine that possessed novel features such as wing venting and blade caps. Results from the simulation were compared with experimental data and it was found that they were in general agreement. The simulations provide continuous information regarding air-flow patterns and velocity distributions during the rotation. Representative patterns of flow are shown.
Advances in the diagnosis of acute pancreatitis in dogs

Abstract In the last 20 years, the diagnosis of pancreatitis has become more frequent as a result of improved diagnostic modalities such as abdominal ultrasound examination, advanced imaging, and immunoassays for the measurement of pancreatic lipase. Our aim is to provide a state‐of‐the‐art overview of the clinical diagnosis of acute pancreatitis (AP) in dogs with a particular focus on pancreatic lipase assay validation and clinical performance, in addition to advanced imaging modalities. We also discuss the potential indications for cytology and histopathology in dogs with suspected AP.