Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical activity behaviour and screen time in Dutch children during the <fc>COVID</fc>â•’19 pandemic: Preâ•’, duringâ•’ and postâ•’school closures

Funding information Province Limburg, Grant/Award Number: SAS-2015-04956 Summary Background: Measures during the COVID-19 pandemic, including the closure of schools and sports facilities, may have lasting impact on the physical activity (PA) of children that persists for a long time. Objective: To investigate the effect of COVID-19 measures on screen time and PA in Dutch children pre-, duringand post-school closures. Methods: In cohort A (n = 102, 10.5 ± 3.6 years, 42.4% boys), data on PA and screen time during the lockdown were collected using a questionnaire. In cohort B (n = 131, 10.2 ± 0.9 years, 43.5% boys), data on PA and screen time were collected using a questionnaire and accelerometry 1 year before and after school closure. Results: In cohort A, 62% reported less total PA. Self-reported screen time on week days increased 34 ± 105 min/d during the lockdown. In cohort B, sedentary time as measured by accelerometry, increased by 45 ± 67 min/d and only 20% reached PA levels of 60 min/d compared to 64% in May 2019. Self-reported screen time increased by 59 ± 112 min/d and 62 ± 130 min/d during week and weekend days, respectively. Conclusions: Children were less physically active, and screen time was higher during and after the school closures due to the COVID-19 lockdown. This is alarming as an active lifestyle in children is crucial in preventing chronic diseases such as obesity.
Efficacy and safety of dupilumab in adult moderate-to-severe atopic dermatitis: An update narrative literature review

Background: Adult atopic dermatitis (AD) is defined as a continuum of childhood AD or the development of the disease in adulthood, accounting for 7.7–59.7% of adult AD cases varying in severity and manifestations. The symptomatology of moderate-to-severe adult AD may significantly impact the overall health and quality of life of the patient. The “classic” topical treatments used in mild-to-moderate cases, such as emollients and topical corticosteroids, are usually not adequate to control the symptoms of most of the patients with moderate-to-severe disease. For many years these patients were managed with systemic corticosteroids and immunomodulators, leading to substantial side effects with questionable efficacy. The introduction of dupilumab, the first biologic agent approved by the Food and Drug Administration for use in adult moderate-to-severe AD, has commenced a new era in the management of AD. This narrative literature review addresses the question of how patients with moderate-to-severe AD may achieve a recession or improvement in the overall progression of the disease with the use of dupilumab in both an efficient and safe way. Material and Methods: A search in the PubMed, Embase, and Cochrane databases was conducted using the following combination of MeSH terms: “dupilumab” AND “atopic” (“dermatitis” OR “eczema”). The searches were limited to RCTs written in the English language published before January 25, 2021. The literature used included phase II and III RCTs examining the efficacy and/or safety of dupilumab compared to placebo or other treatments in adults with moderate-to-severe AD. Moderate-to-severe AD was defined by an IGA score of 3 (moderate) or 4 (severe) and EASI 16 or higher at screening and baseline. Additionally, we searched the website clinicaltrials.gov for any unpublished or ongoing RCTs. The search was done independently by two authors in all databases and followed by the exclusion of duplicates. Results: Upon reviewing all randomized controlled trials, dupilumab was found to be an effective and safe option for managing adult moderate-to-severe AD with long-term therapeutic effects. Conclusion: The best results for maintaining long-term disease recession were achieved with the combination of dupilumab and topical corticosteroids.
Inclusion criteria were any suspected COVID-19 cases with one of the following virological or serological evidence of diagnosis:-Positive RT-PCR for novel SARS-CoV-2 RNA-Positive serum Viral specific IgM and IgG against COVID-19-Viral specific IgG veering from negative to positive [22]

1353 patients, while 30% of patients report shortness of breath. Other symptoms include myalgia, headache, sore throat, and diarrhea [10,11]. An international multicenter study reported that 14% of the infected patients develop a severe disease that requires hospitalization and oxygen support, and 5% require admission to an intensive care unit. In severe cases, COVID-19 can be complicated by acute respiratory distress syndrome (ARDS), sepsis and septic shock, multiorgan failure, including acute kidney injury, myocarditis, stroke and thromboembolic events [12]. Older patients and those with comorbidities, such as cardiovascular disease, diabetes mellitus, obesity, and cancer patients have an increased risk of severe disease and mortality [13]. COVID-19 case fatalities showed some discrepancies across countries [14]. Detecting viral particles using real-time reverse-transcription polymerase chain reaction (RT-PCR) is the gold standard of diagnosis and monitoring [15,16]. Other laboratory tests, such as whole white blood cells (WBCs) count, neutrophil ratio, lymphocyte count, Creactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin, platelets, myoglobin, D-dimer, lactate dehydrogenase (LDH) and numerous other laboratory parameters have been described to change with COVID-19 infection [17,18]. Egypt was considered at an earlier stage of the current epidemic to have the highest risk of SARSCoV-2 infection importation among African countries [19]. On February 14, 2020, Egypt announced the diagnosis of the first case of COVID-19 in Africa. After that, the number of daily reported cases continued to rise until reaching nearly 95,000 cases by Aug 1 [2]. In response to this pandemic, Egypt abandoned individual hospitals in every governorate to be assigned as quarantine hospitals for isolating COVID-19 patients. Additionally, Egyptian MOH issued a standardized guide for the diagnosis and management of COVID-19, where cases are classified on clinical bases into mild, moderate, severe, and critical [20,21]. The current study aimed at describing the epidemiological, clinical, and radiological characteristics of admitted patients with COVID-19 among the Egyptian population.
Delft University of Technology Mapping Surface Heat Fluxes by Assimilating SMAP Soil Moisture and GOES Land Surface Temperature Data

Surface heat fluxes play a crucial role in the surface energy and water balance. In situ measurements are costly and difficult, and large-scale flux mapping is hindered by surface heterogeneity. Previous studies have demonstrated that surface heat fluxes can be estimated by assimilating land surface temperature (LST) and soil moisture to determine two key parameters: a neutral bulk heat transfer coefficient (CHN) and an evaporative fraction (EF). Here a methodology is proposed to estimate surface heat fluxes by assimilating Soil Moisture Active Passive (SMAP) soil moisture data and Geostationary Operational Environmental Satellite (GOES) LST data into a dual-source (DS) model using a hybrid particle assimilation strategy. SMAP soil moisture data are assimilated using a particle filter (PF), and GOES LST data are assimilated using an adaptive particle batch smoother (APBS) to account for the large gap in the spatial and temporal resolution. The methodology is implemented in an area in the U.S. Southern Great Plains. Assessment against in situ observations suggests that soil moisture and LST estimates are in better agreement with observations after assimilation. The RMSD for 30 min (daytime) flux estimates is reduced by 6.3% (8.7%) and 31.6% (37%) for H and LE on average. Comparison against a LST-only and a soil moisture-only assimilation case suggests that despite the coarse resolution, assimilating SMAP soil moisture data is not only beneficial but also crucial for successful and robust flux estimation, particularly when the uncertainties in the model estimates are large.
Identification and characterization of a new cognitive enhancer based on inhibition of insulinâ•’regulated aminopeptidase

Approximately one-quarter of people over the age of 65 are estimated to suffer some form of cognitive impairment, underscoring the need for effective cognitive-enhancing agents. Insulin-regulated aminopeptidase (IRAP) is potentially an innovative target for the development of cognitive enhancers, as its peptide inhibitors exhibit memory-enhancing effects in both normal and memory-impaired rodents. Using a homology model of the catalytic domain of IRAP and virtual screening, we have identified a class of nonpeptide, small-molecule inhibitors of IRAP. Structure-based computational development of an initial “hit” resulted in the identification of two divergent families of compounds. Subsequent medicinal chemistry performed on the highest affinity compound produced inhibitors with nanomolar affinities (Ki 20 –700 nM) for IRAP. In vivo efficacy of one of these inhibitors was demonstrated in rats with an acute dose (1 nmol in 1 l) administered into the lateral ventricles, improving performance in both spatial working and recognition memory paradigms. We have identified a family of specific IRAP inhibitors that is biologically active which will be useful both in understanding the physiological role of IRAP and potentially in the development of clinically useful cognitive enhancers. Notably, this study also provides unequivocal proof of principal that inhibition of IRAP results in memory enhancement. —Albiston, A. L. , Morton, C. J., Ng, H. L. , Pham, V. , Yeatman, H. R. , Ye, S. , Ruani, N. , Fernando, R. N. , De Bundel, D. , Ascher, D. B. , Mendelsohn, F. A. O. , Parker, M. W. , Chai, S. Y. Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. FASEB J. 22, 4209–4217 (2008)
Gardini, Simona and Venneri, Annalena and McGeown, William Jonathan and Toraci, Cristian and Nocetti, Luca and Porro, Carlo Adolfo and Caffarra, Paolo (2016) Brain activation patterns characterizing different phases of motor action : execution, choice and ideation. Brain

Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.
PGPM_A_249361 253..259

Fahdah Al Okaily Seham Alrashidi Mohammad Mustafa 2 Faris Bander Alrashdan 1Department of Rheumatology, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia; 2Scientific Research Center, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia; 3Department of Internal Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia Background: Behcet’s disease (BD) is a complex, inflammatory, immune-mediated multisystemic disease of unknown etiology. Cytokines play major roles in the pathophysiology of BD, and its production may be affected by polymorphism in cytokine genes. Hence, the present study was planned to investigate any possible association between the polymorphism in TGF-β, IFN-γ, and IL-6 genes and BD in the Saudi population. Materials and Methods: The present study includes 79 BD cases and 117 age-matched controls. Polymerase chain reaction with restriction fragment length polymorphism (PCRRFLP) and amplification refractory mutation systems (ARMS) PCR methods were used for polymorphic analysis. Results: The heterozygous (CT) and (CT+TT) combined genotypes of TGF-β (509-C/T), heterozygous (AT), variant (TT), and (AT+TT) combined genotypes of IFN-γ (874-A/T) were significantly (P<0.05) associated with BD in the Saudi population. No significant differences were observed for IL-6 (174-G/C) genotypes and alleles between BD cases and controls. Gender does not reflect any significant genotypic and allelic association with males and females. Conclusion: CT genotype of TGF-β, and AT and TT genotypes of IFN-γ could be associative genetic risk factors for BD in Saudis. Regulatory region polymorphism in cytokines gene can increase inflammation and deregulated immune response, which could be risk factor for BD.
SUPERMANprevents class B gene expression and promotes stem cell termination in the fourth whorl ofArabidopsis thalianaflowers

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Copyright SUPERMANprevents class B gene expression and promotes stem cell termination in the fourth whorl ofArabidopsis thalianaflowers Nathanaël Prunet, Weibing Yang, Pradeep Das, Elliot M. Meyerowitz, Thomas P. Jack
A Life Tangled in Yarns – Leisure Knitting for Well-Being

The main aim of this study is to discuss how craft, and especially yarn techniques, as knitting and crocheting, can provide a meaningful leisure activity, enhance mental well-being and help to untangle demanding situations in life. The theoretical frame for the study is built around craft as a cultural phenomenon in society and education. The starting-point is in literature and research ranging from historical craft skills and industrial manufacturing to learning craft skills, and crafts as a leisure activity for well-being. The empirical data was gathered during a local event in connection to a World Wide Knit in Public Day. The research questions deal with reasons for having knitting and crocheting as a leisure activity, contexts for learning of yarn techniques, and views on mediating yarn technique skills to others, as well as the role of social contexts for crafting as a leisure activity. Research results indicate that reasons for engaging in a crafting activity vary from social affinity to meditative solitude and from creativity and aesthetic experience to a lifeline in personal crises. As a leisure activity craft can be a counterbalance to a stressful job, hectic lifestyle or other demanding situations in life. Even though knitting as a craft is a solitary act, many knitters still enjoy each other’s company. The social events that are arranged around the activity, e.g. courses, knitting cafés, knitting camps and events like World Wide Knit in Public Day, fill an important social role in today’s society and for the individual wellbeing for the participants of the events.
Escherichia coli F 41 Adhesin : Genetic Organization , Nucleotide Sequence , and Homology with the K 88 Determinant

The genetic organization of the polypeptides required for the biosynthesis of the F41 adhesin of enterotoxigenic Escherichia coli strains was investigated. Maxicell analysis demonstrated that a recombinant plasmid which mediated mannose-resistant hemagglutination and F41 antigen production encoded four polypeptides of 29, 30, 32, and 86 kilodaltons. The 29-kilodalton protein was identified as the F41 antigen, and the nucleotide sequence of the gene was determined. Extensive homology was observed between the region encoding the putative signal sequences of the F41 and K88 antigens and in the region immediately upstream of the antigen genes. The nucleotide sequence homology between F41 and K88 determinants was further investigated by Southern blot hybridization. A K88 probe hybridized at high stringency to all fragments shown to be essential for F41 production except for fragments internal to the F41 antigen gene.
Characterization of Aerosol Composition , Aerosol Acidity and Organic Acid Partitioning 1 at an Agriculture-Intensive Rural Southeastern U . S . Site 2 3

Characterization of Aerosol Composition, Aerosol Acidity and Organic Acid Partitioning 1 at an Agriculture-Intensive Rural Southeastern U.S. Site 2 3 Theodora Nah,1 Hongyu Guo,1 Amy P. Sullivan,2 Yunle Chen,1 David J. Tanner,1 Athanasios 4 Nenes,1,3,4,5 Armistead Russell,6 Nga Lee Ng,1,3 L. Gregory Huey1 and Rodney J. Weber1,* 5 6 1School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA 7 2Department of Atmospheric Science, Colorado State University, Fort Collins, CO, USA 8 3School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA 9 4ICE-HT, Foundation for Research and Technology, Hellas, 26504 Patras, Greece 10 5IERSD, National Observatory of Athens, P. Penteli, 15236, Athens, Greece 11 6School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, USA 12 13 * To whom correspondence should be addressed: rweber@eas.gatech. edu 14 15 Abstract 16
Genotype-specificTrp53 Mutational Analysis in Ultraviolet B Radiation-induced Skin Cancers in Xpc and Xpc Trp53Mutant Mice

We have examined the mutational spectrum in theTrp53 gene from UVB radiation-induced skin cancers in Trp53 and Trp53 mutant mice of all three possibleXpcgenotypes. Mutations were detected in exons 2–10 of theTrp53 coding region in ;90% of >80 different skin cancers examined. In contrast to Trp53 mice in which most mutations in the Trp53 gene were located in exons 5–8, the majority of the mutations in Trp53 mice were at other exons. We observed a high predilection for C3T transition mutations at a unique CpG site in codon 122 (exon 4) of the Trp53 gene in Xpc Trp53 mice. This site is not part of a pyrimidine dinucleotide. Mutations at this codon, as well as in codons 124 and 210, were observed exclusively inXpc or Xpc mice. Mutations at the corresponding codons (127 and 213) in the human p53 gene have been reported in skin tumors from human patients with xeroderma pigmentosum. Hence, mutations at codons 122 (125), 124 (127), and 210 (213) may constitute signatures for defective or deficient nucleotide excision repair in mice (humans). In Xpc mice, the majority of mutations were located at C residues in CpG sites, in which the C is presumably methylated. A similar bias can be deduced from studies in human XP individuals.
University of Birmingham Blunted as well as exaggerated cardiovascular reactivity to stress is associated with negative health outcomes

• Users may freely distribute the URL that is used to identify this publication. • Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of private study or non-commercial research. • User may use extracts from the document in line with the concept of ‘fair dealing’ under the Copyright, Designs and Patents Act 1988 (? ) • Users may not further distribute the material nor use it for the purposes of commercial gain.
Frequency of Anaemia in Patients Presenting to a Tertiary Care Hospital in Lahore, Pakistan

Aim: To document the frequency of anaemia in selected patients who were admitted to in-patient in a tertiary level hospital in Lahore, Pakistan and to find the frequency of various grades of anaemia in male and female patients. Methods: This cross sectional, descriptive, institution-based study was conducted in Department of Pathology, Allama Iqbal Medical College Lahore from 15 April 2018 to 15 May 2018. A total of 1000 ‘full blood count’ reports were randomly selected from medicine, surgical, paediatrics, oncology and urology wards for this study which were included. Haemoglobin level <13 g/dL for males and <12g/dL for females was considered as anaemic. Results: Out of a total of 1000 patients, 18% (n=185) were found to be anaemic . There were 82 males (44.32%) and 103 females (55.68%) who were found to be anaemic. Mean haemoglobin level was 7.4±1.3. Moderate and severe anaemia was more common in female patients as compared to males however the difference was not statistically significant (p value=0.9). Conclusion: Anaemia is more commonly encountered in female patients than male patients presenting to different wards of a tertiary care hospital in Lahore.
S204867902100032Xjra 1..9

Body weight dissatisfaction is associated with unhealthy dietary behaviours in young adults, but data are scarce regarding how this relationship evolves with age. The objectives of the present study were to assess the prevalence of body weight dissatisfaction and the association between body weight dissatisfaction, nutrient intake and diet quality in middle-aged and older women. We used data of a population-based sample of 468 middle-aged (50–64 y/o) and older (65–75 y/o) women, extracted from the cross-sectional 2014–15 Swiss National Nutrition Survey. Body weight dissatisfaction was assessed by questionnaire. Dietitians assessed dietary intakes using two non-consecutive computer-assisted multi-pass 24-h dietary recalls and performed anthropometric measurements. Nutrient intakes were calculated and compared with national dietary guidelines, and diet quality scored with the 2010 Alternate Healthy Eating Index (2010-AHEI). 41⋅1 % of women reported body weight dissatisfaction, and 49⋅8 % wanted to lose weight. Body weight dissatisfaction was associated with weight loss desire and a higher body mass index (BMI; P < 0⋅001). Women with body weight dissatisfaction consumed significantly less carbohydrates and dietary fibres, even when BMI was controlled for (P < 0⋅05). They also fell short of national dietary guidelines for magnesium and iron. Body weight dissatisfied women obtained lower 2010-AHEI scores than satisfied women (β −4⋅36, 95 % CI −6⋅78, −1⋅93). However, this association disappeared when the BMI was introduced in the equation. This highlights the importance of targeting both body dissatisfaction and unhealthy eating in obesity prevention and treatment at all ages.
Cognitive-Behavioral and Dialectical Behavioral Therapy: Ef- fectiveness in the Case of Bulimia Nervosa and Borderline Per- sonality Disorder

This study describes the clinical case of a 20-year-old woman diagnosed with Bulimia Nervosa (BN) and Borderline Personality Disorder (BPD). She was evaluated in pretreatment, posttreatment and at 12-month follow-up. EDI 3 and SCL.90-R were used for psychological evaluation. Cognitive Behavioral Therapy (CBT) and Dialectical Behavior Therapy (DBT) were applied for eleven months in a total of 32 one-hour sessions. Strategies for stabilizing eating habits and lifestyle, reducing anxiety, cognitive restructuring and interpersonal effectiveness were used during the treatment. The results after one year showed a decrease in the characteristic symptomatology of BN and BPD. It also showed improvement in general psychopathology and personal and social functioning. The effectiveness of psychological intervention in both eating and emotional pathology was confirmed according to the prognosis in a case of BN and BPD comorbidity.