Miracle-dz/UniFAR-FTUs huggingface dataset:
Side Effect/Complication Risk Related to Injection Branch Level of Chemoembolization in Treatment of Metastatic Liver Lesions from Colorectal Cancer

Purpose: Transarterial chemoembolization with drug eluting beads (DEB-TACE) loaded with irinotecan despite having proven efficacy in the treatment of unresectable liver metastases in the course of colorectal cancer (CRC) does not have an established consistent method. In particular, there are discrepancies in the branch level at which microspheres are administered. Lobar embolization supplies microspheres to all vessels supplying a metastatic lesion but exposes the entire liver parenchyma to negative effects from microsphere irinotecan. Superselective chemoembolization compromises healthy liver parenchyma less but may omit small vessels supplying metastatic lesions. Objective: Assessment of the risk of complications and the severity of postembolization syndromes with CRC metastatic liver lesion chemoembolization with irinotecan-loaded microspheres, according to branch level of chemoembolization. Patients and methods: The analysis included 49 patients (27 female/22 male) with liver metastases in the course of CRC, who underwent 192 chemoembolization treatments (mean 3.62 per patient) with microspheres loaded with 100 mg irinotecan. The procedures were performed according to an adopted schema: alternating the right and left lobe of the liver at 3-week intervals. The severity of postembolization syndrome (PES) and the presence of complications were assessed according to the branch level of chemoembolization; microspheres were administered at the branch level of lobar, segmental, or subsegmental arteries. Assessment of adverse events was performed according to the standards of the Cancer Therapy Evaluation Program Common Terminology Criteria for Adverse Events, Version 5.0. Results: The median survival of all patients from the start of chemoembolization was 13 months. With 192 chemoembolization sessions, 14 (7.3%) serious complications were found. The study showed no significant relationship between the branch level of embolizate administration and the presence of complications (p = 0.2307). Postembolization syndrome was diagnosed after 102 chemoembolization treatments, i.e., 53.1% of treatments. A significant correlation was found between the severity of the postembolization syndrome and the branch level of embolization treatment (p = 0.00303). The mean PES severity increased from subsegmental through segmental to lobar administration. Conclusion: Chemoembolization using Irinotecan-loaded microspheres was relatively well tolerated by patients and gave a low risk of significant complications, which did not change with the branch level of microsphere administration. However, an association was found between the branch level of chemoembolization and the severity of postembolization syndrome. Further research is needed to determine the most effective DEB-TACE chemoembolization technique.
Factors influencing the behavior of online group-buying in Taiwan

This study presents three perspectives of sociology, economics, and psychology to investigate factors influencing the behavior of online group-buying. In Taiwan, group-buying is a unique online business model with great potential for influencing e-business. The study collects information on the demands of consumers to increase bargaining power and get volume discounts or better purchase conditions. In the past, most research focused on the viewpoint of pricing, however, this paper proposes an empirically validated comprehensive model. Data was collected from 327 buyers in an online groupbuying marketplace in Taiwan. The results indicate that reciprocal and conformism of social perspective have the most significant impact on group-buying intentions, followed by the factor of trust from the psychological perspective, and finally the factor of price consciousness and demand externalities from the economic perspective. However, the consumers’ actual behavior is not affected by their intentions.
Text–Image Relationships in Tweets: Shaping the Meanings of an Epidemic

1. Background: While many studies analyze the functions that images can fulfill during humanitarian crises or catastrophes, an understanding of how meaning is constructed in text–image relationships is lacking. This article explores how discourses are produced using different types of text–image interactions. It presents a case study focusing on a humanitarian crisis, more specifically the sexual transmission of Ebola. 2. Methods: Data were processed both quantitatively and qualitatively through a keyword-based selection. Tweets containing an image were retrieved from a database of 210,600 tweets containing the words “Ebola” and “semen”, in English and in French, over the course of 12 months. When this first selection was crossed with the imperative of focusing on a specific thematic (the sexual transmission of Ebola) and avoiding off-topic text–image relationships, it led to reducing the corpus to 182 tweets. 3. Results: The article proposes a four-category classification of text–image relationships. Theoretically, it provides original insights into how discourses are built in social media; it also highlights the semiotic significance of images in expressing an opinion or an emotion. 4. Conclusion: The results suggest that the process of signification needs to be rethought: Content enhancement and dialogism through images have a bearing on Twitter’s use as a public sphere, such as credibilization of discourses or politicization of events. This opens the way to a new, more comprehensive approach to the rhetorics of users on Twitter.
Training-Induced Acute Neuromuscular Responses to Military Specific Test during a Six-Month Military Operation

Limited data are available regarding strength and endurance training adaptations to occupational physical performance during deployment. This study assessed acute training-induced changes in neuromuscular (electromyography; EMG) and metabolic (blood lactate, BLa) responses during a high-intensity military simulation test (MST), performed in the beginning (PRE) and at the end (POST) of a six-month crisis-management operation. MST time shortened (145 ± 21 vs. 129 ± 16 s, −10 ± 7%, p < 0.001) during the operation. Normalized muscle activity increased from PRE to POST in the hamstring muscles by 87 ± 146% (116 ± 52 vs. 195 ± 139%EMGMVC, p < 0.001) and in the quadriceps by 54 ± 81% (26 ± 8 vs. 40 ± 20%EMGMVC, p < 0.001). In addition, higher acute BLa values were measured after MST during POST. Changes in BLa and EMG suggested an increased neural input and metabolic rate during POST MST, likely leading to faster performance times at the end of the operation. High EMG values throughout the different phases of MST suggested that despite the anaerobic nature of the test, the soldiers were able to maintain their voluntary muscle activation level until the end of the test. This indicates only limited neural fatigue during the two-minute high-intensity military specific performance. While learning effect may explain some part of the improvement in the MST performance times, combined strength and endurance training three times per week may improve neuromuscular performance in occupationally relevant tasks.
Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder

Objective To examine the role of genes identified through genome-wide association studies (GWASs) of Parkinson disease (PD) in the risk of isolated REM sleep behavior disorder (iRBD). Methods We fully sequenced 25 genes previously identified in GWASs of PD in a total of 1,039 patients with iRBD and 1,852 controls. The role of rare heterozygous variants in these genes was examined with burden tests. The contribution of biallelic variants was further tested. To examine the potential effect of rare nonsynonymous BST1 variants on the protein structure, we performed in silico structural analysis. Finally, we examined the association of common variants using logistic regression adjusted for age and sex. Results We found an association between rare heterozygous nonsynonymous variants in BST1 and iRBD (p = 0.0003 at coverage >50× and 0.0004 at >30×), driven mainly by 3 nonsynonymous variants (p.V85M, p.I101V, and p.V272M) found in 22 (1.2%) controls vs 2 (0.2%) patients. All 3 variants seem to be loss-of-function variants with a potential effect on the protein structure and stability. Rare noncoding heterozygous variants in LAMP3 were also associated with iRBD (p = 0.0006 at >30×). We found no association between rare heterozygous variants in the rest of genes and iRBD. Several carriers of biallelic variants were identified, yet there was no overrepresentation in iRBD. Conclusion Our results suggest that rare coding variants in BST1 and rare noncoding variants in LAMP3 are associated with iRBD. Additional studies are required to replicate these results and to examine whether loss of function of BST1 could be a therapeutic target.
Possible association of early menopause with worse physical function: a systematic review.

IMPORTANCE Menopause at younger ages is associated with a greater risk of adverse health outcomes such as osteoporosis, chronic diseases, and death. However, the association with physical function has not been well established. OBJECTIVE Assess the association between timing of menopause and different measures of physical function. EVIDENCE REVIEW Searches on the PubMed, Cochrane Library, SciELO, LILACS, and Web of Science databases were conducted. Observational studies on the association between age at menopause and measures of physical function were included, with no restriction for publication date or language. Methodological quality was assessed by the "Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. " FINDINGS Four cross-sectional studies were included, totaling 13,846 participants. These investigated five measures of physical function: gait speed, grip strength, standing balance, chair stand, and self-reported functional limitations. Poor physical function was associated with premature (<40 y) or early menopause (<45 y) in all the studies, with significant results only for grip strength, gait speed, and functional limitation. Premature and early menopause were associated with weaker grip strength [between 2.58 kg (95% CI = 0.74 to 4.43) and 5.21 kg (2.18 to 8.25)], and lower gait speed [between 0.03 m/s (0.01 to 0.06) and 0.06 m/s (0.02 to 0.09)]. Menopause after the age of 50 is associated with less likelihood of functional limitation [OR between 0.52 (95% CI = 0.29 to 0.95) and 0.61 (0.40 to 0.95)] compared with premature and early menopause. Two measures of physical function (chair stand test and standing balance) were not significantly associated with age at menopause. CONCLUSION Only four cross-sectional studies showed that earlier ages at menopause are associated with poor physical function (grip strength, gait speed, and self-reported functional limitations), but given the high heterogeneity of the studies, no consensus is possible. Longitudinal studies are needed to explore the association between age at menopause and different measures of physical function as well as the influence of different socioeconomic conditions between countries on functioning.
Ships Passing in the Night: Spectroscopic Analysis of Two Ultra-faint Satellites in the Constellation Carina

We present Magellan/IMACS, Anglo-Australian Telescope/AAOmega+2dF, and Very Large Telescope/GIRAFFE+FLAMES spectroscopy of the Carina II (Car II) and Carina III (Car III) dwarf galaxy candidates, recently discovered in the Magellanic Satellites Survey (MagLiteS). We identify 18 member stars in Car II, including two binaries with variable radial velocities and two RR Lyrae stars. The other 14 members have a mean heliocentric velocity and a velocity dispersion of . Assuming Car II is in dynamical equilibrium, we derive a total mass within the half-light radius of , indicating a mass-to-light ratio of / . From equivalent width measurements of the calcium triplet lines of nine red giant branch (RGB) stars, we derive a mean metallicity of with dispersion . Considering both the kinematic and chemical properties, we conclude that Car II is a dark-matter-dominated dwarf galaxy. For Car III, we identify four member stars, from which we calculate a systemic velocity of . The brightest RGB member of Car III has a metallicity of . Due to the small size of the Car III spectroscopic sample, we cannot conclusively determine its nature. Although these two systems have the smallest known physical separation ( ) among Local Group satellites, the large difference in their systemic velocities, , indicates that they are unlikely to be a bound pair. One or both systems are likely associated with the Large Magellanic Cloud (LMC), and may remain LMC satellites today. No statistically significant excess of γ-ray emission is found at the locations of Car II and Car III in eight years of Fermi-LAT data.
Ficus deltoidea promotes bone formation in streptozotocin-induced diabetic rats

Abstract Context Diabetes mellitus increases the risk of bone diseases including osteoporosis and osteoarthritis. We have previously demonstrated that Ficus deltoidea Jack (Moraceae) is capable of reducing hyperglycaemia. However, whether F. deltoidea could protect against diabetic osteoporosis remains to be determined. Objective The study examines the effect of F. deltoidea on bone histomorphometric parameters, oxidative stress, and turnover markers in diabetic rats. Materials and methods Streptozotocin (STZ)-induced diabetic Sprague-Dawley rats (n = 6 animals per group) received one of the following treatments via gavage for 8 weeks: saline (diabetic control), metformin (1000 mg/kg bwt), and methanol leaves extract of F. deltoidea (1000 mg/kg bwt). A group of healthy rats served as normal control. The femoral bones were excised and scanned ex vivo using micro-computed tomography (micro-CT) for histomorphometric analysis. The serum levels of insulin, oxidative stress, and bone turnover markers were determined by ELISA assays. Results Treatment of diabetic rats with F. deltoidea could significantly increase bone mineral density (BMD) (from 526.98 ± 11.87 to 637.74 ± 3.90). Higher levels of insulin (2.41 ± 0.08 vs. 1.58 ± 0.16), osteocalcin (155.66 ± 4.11 vs. 14.35 ± 0.97), and total bone n-3 PUFA (2.34 ± 0.47 vs. 1.44 ± 0.18) in parallel with the presence of chondrocyte hypertrophy were also observed following F. deltoidea treatment compared to diabetic control. Conclusions F. deltoidea could prevent diabetic osteoporosis by enhancing osteogenesis and inhibiting bone oxidative stress. These findings support the potential use of F. deltoidea for osteoporosis therapy in diabetes.
Consumer Choices in the Bread Market: The Importance of Fiber in Consumer Decisions

The aim of the current study was two-fold: (1) to identify consumer segments based on bread selection motives and (2) to examine differences between the identified segments in terms of perception of bread and bread with added fiber, and information on the food label. The data were collected using a CAPI (computer-assisted personal interview) survey on a sample of 1013 consumers. The k-means clustering method was used to identify four clusters of consumers, namely, Enthusiastic, Involved, Ultra-Involved, and Neutral. The Enthusiastic was the group that expressed the most positive opinions about the bread and about the addition of fiber to white bread. Moreover, they appreciated the most the information placed on the bread label. On the other hand, the Ultra-Involved and the Involved presented moderate opinions on these issues. In contrast, the consumers from the Neutral segment agreed the least with the opinion that white bread fortified with fiber is healthier and more expensive compared to white bread without added fiber. Consumers belonging to the Enthusiastic segment declared, to a greater extent than others, that cereal products with added fiber facilitate a healthy lifestyle and can reduce the adverse effects of an inadequate diet. The obtained results indicated that relatively positive opinions on the addition of fiber to white bread, including its benefits for health, are an opportunity to further develop the market of cereal products with added fiber. However, the information about bread on the label and its readability should meet the expectations of consumers who differ significantly in terms of their motives for choice. Both now and in the future, this aspect will be a challenge for food entrepreneurs and organizations that are engaged in the education and development of information aimed at consumers.
Monte Carlo-based analysis of the photon beam fluence with air gap thickness between Linac head exit window and patient’s skin in radiotherapy treatments

Linear accelerators (Linac) are used in radiation therapy treatment and its technology improvement ensures high dosimetry quality that should be conserved for high radiotherapy efficiency. However, does the air gap between the exit window of Linac head and patient’s skin alters the physical properties of the photon beam? The objective of this study is to assess the physical properties changes of photon beam fluence according to air gap thickness under the Linac head. The air gap under the Linac head is the last material in the photon beam path; it induces alterations in the beam quality before reaching the patient’s skin. The Varian Clinac 2100 head and the air gap up to the phantom surface are modelled using Monte Carlo BEAMnrc code; the nominal beam energy is 6 MV. The BEAMDP code is used to extract the photon fluence. The photon beam fluence is affected by the air gap under Linac head and decreases by six times due to the photon beam attenuation with air gap thickness; in addition to increasing of beam contamination by scattered photons and electrons. Thus, the air gap induces the beam quality deterioration which is evaluated in terms of photon fluence with air gap thickness. To remove the particles contaminations and conserve integrally the photon beam quality, the number of the photon interactions with air atoms should be as low as possible under Linac head up to patient’s skin and ensure a higher quality of the radiotherapy treatment of deep tumour.
Epidemiological Properties and The Role of Imaging of Pancreatic Carcinoma

Pancreatic cancer is the fourth leading cause of cancer deaths, being responsible for 7% of all cancer-related deaths in both men and women. The aim is to present cases diagnosed with pancreatic carcinoma in UCCK, according to epidemiological variables: age, gender, age group, morbidity, mortality, life expectancy, risk factors and the role of imaging in the diagnosis of pancreatic carcinoma. There are 97 patients included in this retrospective study that were diagnosed with the abovementioned disease in UCCK. The imaging studies were done using ECHO Phillips, 6 and 64 MSCT Siemens and 1.5 T MR Symphony Siemens. The diagnostic apparatuses were sited at the Clinic of Radiology in UCCK Prishtina, and are using anamnesis the life of the Institute of Oncology protocols data from NIPH of Kosova and Kosovo Statistical Agency. In our study results were taken 97 patients diagnosed for the first time in the Radiology Clinic University Clinical Centre in Pristina, 20112014, and have proved these results as follows: age group has been affected with 61 to 70 years old with 40 cases or (41.2%) in both sexes with no significant change but less presented to age over 80 years old of both sexes with 2 cases or (2.1%). dominates males in the ratio 2: 1. The average morbidity rate for the period 2011-2014 is (0.3: 100,000). Moratilitetit rate average for the period 2011-2014 was 5.0: 100,000 residents. Patients who still live from the moment of diagnosis were 6 cases or (6.2%) of them still live. Risk factors present in our study have koreluar with Diabetes Mellitus type II 14:43%, 8.2% gastric ulcer, and smoking 34.0%, 21.6% consuming alcohol. Anatomic localization based on 76 cases (79.4%), resulting in head and neck, 20 cases (21%) in the body and tail, 1 case of pancreatic metastasis from colon carcinoma. The discussion and conclusion was tekonlogic advanced imaging methods make much easier to detect, diagnose staging and management type in patients with pancreatic carcinoma. Correlation risk factor of pancreatic carcinoma is closely related according to numerous studies, in those who had more impact with risk factors, they are two times more likely in the appearance of pancreatic carcinoma.
Fertilization alters protistan consumers and parasites in crop-associated microbiomes.

Crop plants carry an enormous diversity of microbiota that provide massive benefits to hosts. Protists, as the main microbial consumers and a pivotal driver of biogeochemical cycling processes, remain largely understudied in the plant microbiome. Here, we characterized the diversity and composition of protists in sorghum leaf phyllosphere, and rhizosphere and bulk soils, collected from an eight-year field experiment with multiple fertilization regimes. Phyllosphere was an important habitat for protists, dominated by Rhizaria, Alveolata, and Amoebozoa. Rhizosphere and bulk soils had a significantly higher diversity of protists than the phyllosphere, and the protistan community structure significantly differed among the three plant-soil compartments. Fertilization significantly altered specific functional groups of protistan consumers and parasites. Variation partitioning models revealed that soil properties, bacteria and fungi predicted a significant proportion of the variation in the protistan communities. Changes in protists may in turn significantly alter the compositions of bacterial and fungal communities from the top-down control in food webs. Altogether, we provide novel evidence that fertilization significantly affects the functional groups of protistan consumers and parasites in crop-associated microbiomes, which have implications for the potential changes in their ecological functions under intensive agricultural managements. This article is protected by copyright. All rights reserved.
Public service motivation and sectoral employment in Russia: New perspectives on the attraction vs. socialization debate

Abstract Numerous studies have shown that public service motivation (PSM) is higher among public sector employees, particularly in western countries. But whether these trends result from high-PSM individuals selecting into public sector employment or from on-the-job socialization remains subject to debate. We address this question utilizing novel panel data on Russian university students. Examining the relationships between PSM and sectoral employment both before and after students enter the labor force, we find that: (1) high-PSM students are more likely to prefer public sector employment; (2) high-PSM students are more likely to be employed in the public sector following graduation; and (3) PSM increases upon entry into the workplace at approximately the same rate in both the public and private sectors. These findings suggest that at least during early career stages, the association between PSM and public sector employment results largely from an attraction-selection process, rather than a socialization process. Our analyses additionally provide evidence that theories of PSM based on the western experience may generalize to the context of developing or post-communist countries, despite the prevalence of corruption and a less pronounced public service ethos in many of these countries.