Miracle-dz/UniFAR-FTUs huggingface dataset:
Sedentary Time and Physical Activity in Older Women Undergoing Exercise Training

ABSTRACT Older adults have low rates meeting the physical activity (PA) guidelines and high sedentary time. Low PA and excessive sedentary time have been linked to adverse health outcomes. Less is known about whether exercise training influences sedentary time and PA in various intensities. Purpose This study aimed to examine the effects of a 16-wk aerobic exercise training on time spent being sedentary and on light-intensity PA (LPA) and moderate- to vigorous-intensity PA (MVPA) and step numbers in older women. Methods Inactive women (n = 61; age = 65.5 ± 4.3 yr) participated in moderate-intensity walking of either a low or a moderate dose (33.6 and 58.8 kJ·kg−1 body weight per week, respectively). They wore a SenseWear Mini Armband at baseline and at end intervention to determine sedentary, LPA, and MVPA time and step numbers. Results Time being sedentary, or spent on LPA and MVPA, did not change differently by exercise groups with different doses (all P values for group–time interaction >0.580). Overall, time being sedentary reduced from baseline to end intervention by approximately 39 min·d−1 (P < 0.001), and LPA increased by 19 min·d−1 (P = 0.003). MVPA time increased (P < 0.001), which was primarily accounted for by the supervised exercise. Interestingly, daily steps increased more in the moderate-dose than the low-dose group (P = 0.023 for group–time interaction; 33.6% and 19.8% median increase in moderate- and low-dose groups, respectively). Also, there were individual differences in these changes. Conclusion Results indicated that, on average, older women did not reduce time of LPA or MVPA outside the exercise program or increase sedentary time as a result of participating in the exercise program.
The rediscovery of Codonorchis octaedrus (Hydroidomedusae, Anthomedusae, Pandeidae), with an update of the Mediterranean hydroidomedusan biodiversity

Abstract Codonorchis octaedrus is recorded for the first time since its discovery by Haeckel in 1879. A hydroid colony collected in a cave of the Apulian Coast (between the Ionian and the Adriatic Seas) produced several medusae which have been reared to maturity. This is the first complete description of the species, which was previously considered as doubtful, as was the genus Codonorchis. The diagnostic features for the genus are: hydroid small, naked, sessile, with a single row of few tentacles, gono‐phores on hydrorhiza, medusa with apical projection with apical process from the manubrium, perradial, interradial and adradial ocellate bulbs, two perradial tentacles, horseshoe‐shaped interradial gonads, small mesenteries. The list of Mediterranean hydroidomedusae is updated with the new (or overlooked) records since the last published list (1993). The increase in species number is great (about 10%), showing that the knowledge of biodiversity of even a well‐studied sea as the Mediterranean is far from be.
Genetic Improvement of Seedling Emergence of Low‐Phytate Soybean Lines

Reduced seedling emergence of low-phytate (LP) soybean [Glycine max (L.) Merr. ] lines with the pha1 and pha2 alleles has been a limiting factor in the development of LP cultivars. Crosses between normal-phytate (NP) and LP soybean lines have produced progeny with improved emergence. The objective of this study was to determine if LP lines with improved emergence are capable of producing progeny with equal or higher emergence when crossed to NP parents. Low-phytate lines with improved emergence were crossed to NP cultivars and the LP progeny were evaluated with seed produced at three 2007 locations and fi ve 2008 locations. A fi eld test of the lines was conducted in 2008 with one 2007 seed source. An extended cold test (ECT) was developed to evaluate all the lines with the three 2007 seed sources and selected lines and parents with the fi ve 2008 sources. There were LP progeny with signifi cantly less emergence than the LP parent when evaluated in the fi eld and with the ECT. One single-cross line had signifi cantly greater emergence than the LP parent and emergence equal to the NP parent. Genetic variation among the single-cross and backcross lines was attributed to the segregation of favorable and unfavorable alleles for emergence from both the NP and LP parents. Multiple seed sources should be used to identify LP lines with superior emergence based on fi eld evaluations or the ECT.
Role of circulating tumor DNA in the detection of sensitizing and resistance to epidermal growth factor receptor mutations in metastatic lung adenocarcinoma.

PURPOSE The EGFR (Epidermal Growth Factor Receptor) mutations may predict sensitivity and resistance to EGFR-TKIs (Tyrosine Kinases Inhibitors) in metastatic lung adenocarcinoma. The detection of these mutations is usually performed on tumor tissue samples. However, when a biopsy is not feasible or the amount of tissue is limited, circulating tumor DNA (ctDNA) may represent an alternative source for genotyping the tumor. METHODS In the first phase of the study, the liquid biopsy was performed in newly diagnosed metastatic lung adenocarcinoma patients with and without EGFR mutations to evaluate the concordance between EGFR mutational analysis on ctDNA by real time PCR and on tissue. In the second phase it was performed in EGFR positive patients progressing after first or second generation TKIs in order to detect the T790M mutation. RESULTS In the first phase, a 100% concordance between EGFR on ctDNA and tissue was revealed, leading to validation of the test. In the second phase, 44.8% of patients showed T790M positive result at liquid biopsy. Considering the re-biopsies performed in 31% of the cases, the overall positivity rate of T790M was 58.6%. Sensitivity and specificity were 76% and 75%, respectively. The median time to development of T790M mutation from the start of first line EGFR TKI was 244 days. CONCLUSIONS Our experience confirms that liquid biopsy is a valid method to detect sensitizing and resistant EGFR mutations in patients with metastatic lung adenocarcinoma. Nevertheless, in the presence of negative ctDNA analysis, a rebiopsy should be performed whenever possible to confirm this result.
Association Between Residential Neighborhood Social Conditions and Health Care Utilization and Costs

Supplemental Digital Content is available in the text. Background: Social factors are important drivers of health. However, it is unclear to what extent neighborhood social conditions are associated with total and preventable health care utilization and costs. Objectives: To examine the association of neighborhood social conditions with total annual and potentially preventable Medicare costs. Research Design and Subjects: Retrospective cohort study. Medicare claims data from 2013 to 2014 linked with neighborhood social conditions at the US census block group level of 2013 for 93,429 Medicare fee-for-service and dually eligible patients. Measures: Neighborhood social conditions were measured by Area Deprivation Index at the census block group level, categorized into quintiles. Outcomes included total annual and potentially preventable utilization and costs. Results: After adjustment for demographics and comorbidities, patients with the least disadvantaged social conditions had higher total annual Medicare costs [$427; 95% confidence interval (CI), $200–$655] and similar potentially preventable costs (−$23; 95% CI, −$56 to $10) as compared with patients with the intermediate level social conditions. Patients with the most disadvantaged social conditions had similar total Medicare costs (−$22; 95% CI, −$342 to $298) but higher potentially preventable costs ($53; 95% CI, $1–$104) than patients with the intermediate level social conditions. Conclusions: Disadvantaged neighborhood conditions are associated with lower total annual Medicare costs but higher potentially preventable costs after controlling for demographic, medical, and other patient characteristics. Socioeconomic barriers may limit access and use of primary care and disease management services, resulting in a higher proportion of their health care costs going to potentially preventable care.
Low‐Density Neutrophils in Systemic Lupus Erythematosus

Patients with systemic lupus erythematosus (SLE) display increased numbers of immature neutrophils in the blood, but the exact role of these immature neutrophils is unclear. Neutrophils that sediment within the peripheral blood mononuclear cell fraction after density centrifugation of blood are generally defined as low‐density neutrophils (LDNs). Far beyond antimicrobial functions, LDNs are emerging as decision‐shapers during innate and adaptive immune responses. Traditionally, neutrophils have been viewed as a homogeneous population. However, the various LDN populations identified in SLE to date are heterogeneously composed of mixed populations of activated mature neutrophils and immature neutrophils at various stages of differentiation. Controversy also surrounds the role of LDNs in SLE in terms of whether they are proinflammatory or polymorphonuclear myeloid‐derived suppressor cells. It is clear that LDNs in SLE can secrete increased levels of type I interferon (IFN) and that they contribute to the cycle of inflammation and tissue damage. They readily form neutrophil extracellular traps, exposing modified autoantigens and oxidized mitochondrial DNA, which contribute to autoantibody production and type I IFN signaling, respectively. Importantly, the ability of LDNs in SLE to perform canonical neutrophil functions is polarized, based on mature CD10+ and immature CD10− neutrophils. Although this field is still relatively new, multiomic approaches have advanced our understanding of the diverse origins, phenotype, and function of LDNs in SLE. This review updates the literature on the origin and nature of LDNs, their distinctive features, and their biologic roles in the immunopathogenesis and end‐organ damage in SLE.
Influence of Preoperative Keratometry on Refractive Outcomes for Myopia Correction With Small Incision Lenticule Extraction.

PURPOSE To evaluate the effect of preoperative keratometry on refractive outcomes after small incision lenticule extraction (SMILE) for myopia. METHODS This retrospective study comprised 515 consecutive eyes that had SMILE to correct myopia. Pearson correlation and linear regression were used to determine the relationship between residual spherical equivalent and preoperative keratometry. The same analyses were repeated in the quartiles with the lowest and highest preoperative myopia. RESULTS Preoperatively, the mean spherical equivalent was -5.67 ± 1.87 diopters (D) (range: -1.63 to -9.75 D) and the mean keratometry was 43.10 ± 1.30 D (range: 38.90 to 47.00 D). Three months postoperatively, the mean spherical equivalent was -0.07 ± 0.18 D. After adjustment for age, sex, and preoperative spherical equivalent, greater postoperative undercorrection occurred in eyes with steeper corneas (P = .001). Each diopter of steeper keratometry resulted in 0.52% (0.03 D) more undercorrection. Correlation between the mean preoperative keratometry and residual spherical equivalent was significant in the lower preoperative myopia group (r = -0.24, P = .006), but not significant in the higher myopia group (r = -0.02, P = .809). CONCLUSIONS Preoperative keratometry affects refractive outcomes after SMILE. Steeper corneas have greater undercorrection, especially in eyes with low myopia. Knowledge of the correlation between refractive outcomes of SMILE and keratometry would help in modifying current treatment algorithms. [J Refract Surg. 2020;36(6):374-379. ].
Evolution of Interfacial Shear Strength and Mean Intrinsic Single Strength in Biobased Composites from Bio-Polyethylene and Thermo-Mechanical Pulp-Corn Stover Fibers

In this article, with the aim of promoting sustainability, contributing to the circular economy and the fight against climate change, the production of composite materials from Bio-polyethylene reinforced with corn stover fibers has been studied. The behavior of the materials obtained has been studied experimentally and by mathematical models of micromechanics. The composite materials were produced by extrusion and then injection with from 10 to 50 wt. % of fibers. The creation of a good fiber-matrix interface was studied by the incorporation of coupling agent between (0–8 wt.%). Increase of 131.2% on tensile strength for 40wt. % reinforcement was achieved by adding 6 wt. % of coupling agent. The correct interface was demonstrated by a correlation of 0.99 between the experimental results and the results of the mathematical models used.
Predicting the naturalistic course in anxiety disorders using clinical and biological markers: a machine learning approach

Abstract Background Disease trajectories of patients with anxiety disorders are highly diverse and approximately 60% remain chronically ill. The ability to predict disease course in individual patients would enable personalized management of these patients. This study aimed to predict recovery from anxiety disorders within 2 years applying a machine learning approach. Methods In total, 887 patients with anxiety disorders (panic disorder, generalized anxiety disorder, agoraphobia, or social phobia) were selected from a naturalistic cohort study. A wide array of baseline predictors (N = 569) from five domains (clinical, psychological, sociodemographic, biological, lifestyle) were used to predict recovery from anxiety disorders and recovery from all common mental disorders (CMDs: anxiety disorders, major depressive disorder, dysthymia, or alcohol dependency) at 2-year follow-up using random forest classifiers (RFCs). Results At follow-up, 484 patients (54.6%) had recovered from anxiety disorders. RFCs achieved a cross-validated area-under-the-receiving-operator-characteristic-curve (AUC) of 0.67 when using the combination of all predictor domains (sensitivity: 62.0%, specificity 62.8%) for predicting recovery from anxiety disorders. Classification of recovery from CMDs yielded an AUC of 0.70 (sensitivity: 64.6%, specificity: 62.3%) when using all domains. In both cases, the clinical domain alone provided comparable performances. Feature analysis showed that prediction of recovery from anxiety disorders was primarily driven by anxiety features, whereas recovery from CMDs was primarily driven by depression features. Conclusions The current study showed moderate performance in predicting recovery from anxiety disorders over a 2-year follow-up for individual patients and indicates that anxiety features are most indicative for anxiety improvement and depression features for improvement in general.
The Effects of a Pain Psychology and Neuroscience Self-Evaluation Internet Intervention

Objectives: Many patients’ chronic musculoskeletal pain is strongly influenced by central nervous system processes such as sensitization or amplification. Education about pain neuroscience can change patients’ beliefs but has less consistent effects on pain outcomes. Patients may have greater clinical benefits if the educational intervention is personalized, and they evaluate various psychosocial risk factors with respect to their pain. We developed and tested a brief, internet-based Pain Psychology and Neuroscience (PPN) self-evaluation intervention. Materials and Methods: From a patient registry, 104 adults reporting chronic musculoskeletal pain were randomized to the PPN intervention or a matched, active, education control condition. At baseline and 1-month (primary endpoint) and 10-month follow-ups, participants reported pain severity (primary outcome) and multiple secondary outcomes. Primary analyses compared the 2 experimental conditions using analyses of covariances; post hoc exploratory analyses compared the effects of PPN in subgroups of patients who met criteria for fibromyalgia (FM; n=50) or who did not (n=54; primarily spinal pain). Results: At 1-month follow-up, compared with the control condition, PPN led to significantly lower pain severity (ηp 2=0.05) and interference (ηp 2=0.04), greater brain (ηp 2=0.07) and psychological (ηp 2=0.07) attributions for pain, and greater readiness for pain self-management (ηp 2=0.08). Effects on distress, pain catastrophizing, kinesiophobia, and life satisfaction were not significant. Exploratory analyses showed that the PPN intervention was especially beneficial for patients without FM but was of less benefit for those with FM. Most of the effects (except attributions) were lost at 10 months. Discussion: A brief PPN self-evaluation intervention, presented on-line, can yield short-term improvements in musculoskeletal pain severity and interference, especially for people with spinal/localized pain rather than FM, perhaps because the psychology/neuroscience perspective is more novel for such patients.
Spatial and Temporal Analysis of Host Cells in Tracheal Graft Implantation

The ideal trachea replacement would be a living graft that is genetically identical to the host, avoiding the need for immunosuppression. We have developed a mouse model of syngeneic tracheal transplant that results in long‐term survival without graft stenosis or delayed healing. To understand how host cells contribute to tracheal transplant integration, we quantified the populations of host cells in the graft and native trachea following implant.
The extent to which mobile applications support independence among the visually impaired – a pilot study

Abstract Background and aim Visual impairment (VI) problems are increasing as the global aging population grows. Mobile devices have become essential to interacting with friends and society. Because the visually impaired are no exception, it would be useful to determine the functionalities that best support the independence of people with VI. The currently available functionalities and applications were analysed to provide insight about which features the visually impaired value most. Materials and methods A Webropol survey with structured and open-ended questions was carried out. The participants (n = 26) were asked about their use of mobile applications and opinions regarding the usefulness of certain applications in promoting independent functioning. An instrument was developed for this study based on previous literature, and its quality was assured through an expert panel evaluation and pre-testing. The collected data were analysed statistically and by inductive content analysis. Results A majority of the participants were active users of mobile devices. Substantial variation was observed in the evaluations of how useful various applications are to different everyday tasks. The participants suggested numerous improvements, such as additional customization, to the current mobile devices and applications. Implications for Rehabilitation People with VI benefit from the use of mobile devices in the same way that the population with normal vision does, and mobile devices and applications can be pivotal to supporting their independence. The participants offered innovative ideas and suggestions for how mobile devices and applications could be designed to better meet the needs of the visually impaired.
Exploring Future Research in Adapted Physical Education

ABSTRACT Quality physical education can play a critical role in helping students become more active, physically literate, and develop the skills and interests to remain physically active throughout their lives. The healthy, physically active student is more likely to be academically motivated, alert, and successful in school. Unfortunately, findings from multiple studies interviewing students with disabilities suggest that students with disabilities are often less active and feel more socially separated from the class compared to their classmates without disabilities in general physical education. Clearly, more research is needed to identify best practices or strategies for creating a positive learning environment in physical education for all students. This paper examines future research considerations based on what we currently know about the physical education experiences and concerns of students with disabilities as well as concerns voiced by general physical educators. Considerations include: (1) What evidence do we have and what evidence do we need to show students with 3 disabilities are receiving appropriate physical education whether included or in a separate setting? (2) What evidence do we have and what evidence do we need to show that physical educators are properly trained and qualified to provide physical education to students with disabilities? (3) What evidence do we have and what evidence do we need to show that particular curricular and teaching models are effective when including students with disabilities in general physical education and when working in small groups or one-on-one? (4) What evidence do we have and what evidence do we need to show that students with disabilities are socially part of the class and not simply physically present.
Comparative Pathogenesis of Bovine and Porcine Respiratory Coronaviruses in the Animal Host Species and SARS-CoV-2 in Humans

Discovery of bats with severe acute respiratory syndrome (SARS)-related coronaviruses (CoVs) raised the specter of potential future outbreaks of zoonotic SARS-CoV-like disease in humans, which largely went unheeded. Nevertheless, the novel SARS-CoV-2 of bat ancestral origin emerged to infect humans in Wuhan, China, in late 2019 and then became a global pandemic. Less than 5 months after its emergence, millions of people worldwide have been infected asymptomatically or symptomatically and at least 360,000 have died. ABSTRACT Discovery of bats with severe acute respiratory syndrome (SARS)-related coronaviruses (CoVs) raised the specter of potential future outbreaks of zoonotic SARS-CoV-like disease in humans, which largely went unheeded. Nevertheless, the novel SARS-CoV-2 of bat ancestral origin emerged to infect humans in Wuhan, China, in late 2019 and then became a global pandemic. Less than 5 months after its emergence, millions of people worldwide have been infected asymptomatically or symptomatically and at least 360,000 have died. Coronavirus disease 2019 (COVID-19) in severely affected patients includes atypical pneumonia characterized by a dry cough, persistent fever, and progressive dyspnea and hypoxia, sometimes accompanied by diarrhea and often followed by multiple organ failure, especially of the respiratory and cardiovascular systems. In this minireview, we focus on two endemic respiratory CoV infections of livestock: bovine coronavirus (BCoV) and porcine respiratory coronavirus (PRCV). Both animal respiratory CoVs share some common features with SARS-CoV and SARS-CoV-2. BCoV has a broad host range including wild ruminants and a zoonotic potential. BCoV also has a dual tropism for the respiratory and gastrointestinal tracts. These aspects, their interspecies transmission, and certain factors that impact disease severity in cattle parallel related facets of SARS-CoV or SARS-CoV-2 in humans. PRCV has a tissue tropism for the upper and lower respiratory tracts and a cellular tropism for type 1 and 2 pneumocytes in lung but is generally a mild infection unless complicated by other exacerbating factors, such as bacterial or viral coinfections and immunosuppression (corticosteroids).