Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and safety of ondansetron for morning sickness in pregnancy: a systematic review of clinical trials

Background: Ondansetron is a selective antagonist of the serotonin 5-HT3 receptor that is commonly used to treat morning sickness. It is estimated that 70%–80% of pregnant women suffer from morning sickness, a condition characterized by nausea and vomiting. However, it is still controversial regarding its safety during pregnancy, and continued research will be necessary to fully understand the risks and benefits associated with its use. Therefore, we aimed to identify and provide details of the efficacy and safety of ondansetron in clinical trials. Methods: A search was conducted of the ClinicalTrials.gov database on 13 April 2023, using the search term “ondansetron and pregnancy. ” Inclusion and exclusion criteria were defined to identify relevant clinical trials. The inclusion criteria encompassed clinical trials related to pregnancy that utilized ondansetron as a treatment, while other clinical trials were excluded from consideration. All data extractions such as study title, study status, study type, intervention details, and outcome were collected. Results: A total of 18 clinical trials were identified, of which only 6 focused on studying the effects of ondansetron. Their respective study titles, statuses, conditions, interventions, outcome measures, and enrollment sizes have been written in detail. The information collected from these trials will contribute to our understanding of the potential benefits and risks of ondansetron in the context of pregnancy and its complications. Conclusion: Ondansetron has been shown to be an effective treatment for nausea and vomiting, including pregnancy-related morning sickness. Further research is needed to better understand the potential risks and benefits associated with its use in pregnant women. Systematic Review Registration: ClinicalTrials.gov, identifier
Characterization of New Alpha Zero (α0) Thalassaemia Deletion (−−GB) among Malays in Malaysian Population

Malaysia is a multicultural and multiethnic country comprising numerous ethnic groups. From the total population of 32.7 million, Malays form the bulk of the Bumiputera in Malaysia comprise about 69.9%, followed by Chinese 22.8%, Indian 6.6%, and others 0.7%. The heterogeneous population and increasing numbers of non-citizens in this country affects the heterogeneity of genetic diseases, diversity, and heterogeneity of thalassaemia mutations. Alpha (α)-thalassaemia is an inherited haemoglobin disorder characterized by hypochromic microcytic anaemia caused by a quantitative reduction in the α-globin chain. A majority of the α-thalassaemia are caused by deletions in the α-globin gene cluster. Among Malays, the most common deletional alpha thalassaemia is −α3. 7 deletion followed by −−SEA deletion. We described the molecular characterization of a new −−GB deletion in our population, involving both alpha genes in cis. Interestingly, we found that this mutation is unique among Malay ethnicities. It is important to diagnose this deletion because of the 25% risk of Hb Bart’s with hydrops fetalis in the offspring when in combination with another α0- thalassaemia allele. MLPA is a suitable method to detect unknown and uncommon deletions and to characterize those cases which remain unresolved after a standard diagnostic approach.
Hardware Architecture of Channel Encoding for 5G New Radio Physical Downlink Control Channel

In this article, we propose a flexible and parallelizable hardware architecture of the channel encoding chain for the fifth generation new radio (5G NR) physical downlink control channel (PDCCH). We propose a new polar encoder architecture based on the radix-k processing and fast Fourier transform (FFT) concepts. We also introduce the hardware architectures for cyclic redundancy check (CRC) interleaver and rate matcher for 5G NR PDCCH. We synthesized this complete channel encoding chain on a Virtex Ultrascale+ field-programmable gate-array (FPGA) and show that with the proposed architecture, a codeword throughput of 4.26 Gbps can be realized while consuming as little as 3% of FPGAs resources. The proposed polar encoding architecture can encode from 84 up to 164 resource blocks in the 5G NR frame structure. Encoding of multiple resource blocks can be systematically applied to highly dense (time and frequency) 5G NR fronthaul links supporting multiple antennas.
Police officers’ perspective on doping and prevention among recreational athletes: a cross-sectional study

Introduction The use of anabolic androgenic steroids among recreational athletes has received growing attention in recent decades. Several countries have implemented bans on doping; however, recreational athletes and other subpopulations continue to use doping substances. Recognizing that the police play a crucial role in preventing the use and dealing of doping substances in Sweden, efforts have been made to intensify police interventions and enhance collaboration with other key actors. This study examined police officers’ perceptions of doping as defined in Swedish law, related problems, and suggestions for effective prevention of doping in the society. Methods A cross-sectional survey study was conducted using a web survey of police officers (N = 597). Data were analyzed using descriptive statistics and free-form text responses were analyzed using content analysis. Results Participant responses to the survey (73.7% response rate) indicated that approximately 62.6% thought that doping is a societal problem, and approximately 26% perceived that the availability of doping substances has increased over the past three years. A total of 95.6% of respondents believed that doping occurred in connection with other crimes such as intimate partner violence (88.2%) and drug-related crimes (88.0%). Further, 96.3% of respondents perceived that it was their duty to prevent doping, but 63.8% indicated that doping-related work was not prioritized within their local police district. Discussion Police officers perceived doping as a societal problem and expressed motivation to counteract it, highlighting increased knowledge, legislative changes, intensified doping prevention in gyms, and commitment from other societal actors to increase the effectiveness of doping prevention. Suggestions for increasing the efficiency of doping prevention included education and increased knowledge at all levels in the police organization, intensified prevention efforts at gyms, legislative changes to permit simplified doping test procedures, and breach of secrecy for postal items. There was also a suggestion for further engagement from other actors, such as healthcare workers, school officials, and non-governmental organizations.
Finite Blocklength Coding Scheme for RIS-Aided MIMO Channel with Noisy Feedback

Recently, the reconfigurable intelligent surface (RIS) aided communication system receives much attention. However, to the best of the authors' knowledge, the constructive finite blocklength (FBL) coding scheme for RIS aided channel remains open. In this paper, first, we propose a FBL coding scheme for the RIS aided MIMO channel (no direct link between the transceiver) with noisy feedback, which is based on an existing coding scheme for the point-to-point white Gaussian channel with noisy feedback. Then, numerical results show that the corresponding achievable rate approaches the Shannon limit when the blocklength is not long enough.
RESPIRATORY HEALTH OF DIGGING AND EXCAVATING WORKERS INVOLVED IN CONSTRUCTING A DAM IN FARS PROVINCE FOLLOWING OCCUPATIONAL EXPOSURE TO VERY HIGH CONCENTRATIONS OF DOLOMITE DUST

Background and aims : To date, there is not enough information about the toxic effects of dolomite. The purpose of this study was to assess the extent to which digging and excavating workers involved in constructing a dam in Fars province were exposed to dolomite dust and to evaluate the possible effects of this exposure on the prevalence of respiratory symptoms, functional impairments and radiographic abnormalities of the lungs. Methods: This cross sectional study was carried out at the constructing site of a dam in Shiraz, south of Iran. The study population consisted of thirty nine male workers with current exposure to dolomite dust and 40 healthy male unexposed employees. To determine the prevalence of respiratory symptoms, respiratory symptoms questionnaire were used. Personal dust samplers were used to assess the exposure concentrations. Additionally, subjects underwent lung function tests and chest X-ray. Results: Atmospheric concentrations of dolomite dust exceeded current permissible levels. Exposed workers had significantly higher prevalence rates of respiratory symptoms than their referent counterparts (P<0.05). Similarly, decrements were noted in most parameters of pulmonary functions of exposed workers, although the difference was only significant for FEV1/FVC ratio (P<0.05). No significant differences were noted between exposed and referent subjects as far as their chest radiographs were concerned. Conclusions: The findings of this study indicate that medium term exposure to very high concentration of dolomite dust is likely to be associated with respiratory symptoms.
Identification of Molecular Subtypes and Prognostic Characteristics of Adrenocortical Carcinoma Based on Unsupervised Clustering

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Increasing evidence highlights the significant role of immune-related genes (IRGs) in ACC progression and immunotherapy, but the research is still limited. Based on the Cancer Genome Atlas (TCGA) database, immune-related molecular subtypes were identified by unsupervised consensus clustering. Univariate Cox analysis and Least Absolute Shrinkage and Selection Operator (LASSO) regression were employed to further establish immune-related gene signatures (IRGS). An evaluation of immune cell infiltration, biological function, tumor mutation burden (TMB), predicted immunotherapy response, and drug sensitivity in ACC patients was conducted to elucidate the applicative efficacy of IRGS in precision therapy. ACC patients were divided into two molecular subtypes through consistent clustering. Furthermore, the 3-gene signature (including PRKCA, LTBP1, and BIRC5) based on two molecular subtypes demonstrated consistent prognostic efficacy across the TCGA and GEO datasets and emerged as an independent prognostic factor. The low-risk group exhibited heightened immune cell infiltration, TMB, and immune checkpoint inhibitors (ICIs), associated with a favorable prognosis. Pathways associated with drug metabolism, hormone regulation, and metabolism were activated in the low-risk group. In conclusion, our findings suggest IRGS can be used as an independent prognostic biomarker, providing a foundation for shaping future ACC immunotherapy strategies.
H-Dot Mediated Nanotherapeutics Mitigate Systemic Toxicity of Platinum-Based Anticancer Drugs

Platinum-based anticancer agents have revolutionized oncological treatments globally. However, their therapeutic efficacy is often accompanied by systemic toxicity. Carboplatin, recognized for its relatively lower toxicity profile than cisplatin, still presents off-target toxicities, including dose-dependent cardiotoxicity, neurotoxicity, and myelosuppression. In this study, we demonstrate a delivery strategy of carboplatin to mitigate its off-target toxicity by leveraging the potential of zwitterionic nanocarrier, H-dot. The designed carboplatin/H-dot complex (Car/H-dot) exhibits rapid drug release kinetics and notable accumulation in proximity to tumor sites, indicative of amplified tumor targeting precision. Intriguingly, the Car/H-dot shows remarkable efficacy in eliminating tumors across insulinoma animal models. Encouragingly, concerns linked to carboplatin-induced cardiotoxicity are effectively alleviated by adopting the Car/H-dot nanotherapeutic approach. This pioneering investigation not only underscores the viability of H-dot as an organic nanocarrier for platinum drugs but also emphasizes its pivotal role in ameliorating associated toxicities. Thus, this study heralds a promising advancement in refining the therapeutic landscape of platinum-based chemotherapy.
Study on Network Importance for ML End Application Robustness

In this paper, we investigate the robustness of the ML end application performance to network Quality of Service (QoS) degradation, and the ways to improve it. We introduce a novel system approach to define the Machine Learning (ML) with Integrated Networks (MLINs) and describe how ML end performance can be employed to adjust network hyperparameters in order to prevent system Data Quality decrease. We investigate the interrelations between the network QoS degradation during the data transmission and ML image classification performance. We demonstrate how the studied interrelationships can be employed to produce recommendations on network adjustment in order to improve MLIN robustness. In particular, we propose an example of MLIN feedback system design that employs ML end performance as the major indicator to produce recommendations on network hyperparameters adjustment aimed at improving MLIN robustness.
Silver-Coated Distal Femur Megaprosthesis in Chronic Infections with Severe Bone Loss: A Multicentre Case Series

Periprosthetic joint infections (PJI) and fracture-related infections (FRI) of the distal femur (DF) may result in massive bone defects. Treatment options include articulated silver-coated (SC) megaprosthesis (MP) in the context of a two-stage protocol. However, there is limited evidence in the literature on this topic. A retrospective review of the prospectively maintained databases of three Institutions was performed. Forty-five patients were included. The mean follow-up time was 43 ± 17.1 months. Eight (17.8%) patients had a recurrent infection. The estimated recurrence-free survival rate was 91.1% (93.5% PJI vs. 85.7% FRI) 2 years following MP implantation, and 75.7% (83.2% PJI vs. 64.3% FRI; p = 0.253) after 5 years. No statistically relevant difference was found according to the initial diagnosis (PJI vs. FRI). Among possible risk factors, only resection length was found to significantly worsen the outcomes in terms of infection control (p = 0.031). A total of eight complications not related to infection were found after reimplantation, but only five of them required further surgery. Above-the-knee amputation was performed in two cases (4.4%), both for reinfection. Articulated DF SC MP in a two-stage protocol is a safe and effective treatment for chronic knee infection with severe bone loss.
Seismicity, earthquake mechanisms, and tectonics along the western coast of North America, from 42°N to 61°N

Seismicity maps of the region are presented for the periods January 1900 to June 1973 and January 1961 to June 1973. Focal mechanism solutions for 24 earthquakes (mb ≧ 5.5) occurring between January 1963 to July 1973 have been determined. Four earthquakes which occurred in the vicinity of the Gorda ridge have a component of normal faulting, thus identifying it as a spreading ridge. However, departure of the trend of the axis of tension, determined in the focal mechanism solutions for these earthquakes, from being perpendicular to the trend of the ridge axis indicates that the tectonics of the Gorda basin is complex. The existence of the Blanco fracture zone and the Queen Charlotte Islands fault as dextral transform faults, east block moving south, is confirmed. Evidences derived from the focal mechanism solutions indicate that the Revere-Dellwood and Sovanco fracture zones are also right-lateral transform faults. The northern extent of the Queen Charlotte Islands fault probably terminates near 54.5°N, 135.2°W or 57.5°N, 136°W. Focal mechanism solutions for an earthquake occurring near Vancouver Islands and another near the Puget Sound region in Washington indicate normal faulting and suggest the presence of a downgoing slab of lithosphere in this region. The interpretation is that the former results from tension caused by the bending of the plate as it dips under the continent and the latter results from tension within the sinking slab. Two recent earthquakes which occurred on July 1 and July 3, 1973 at a latitude of about 58°N, have thrust fault solutions and together with the seismicity data suggest a zone of underthrusting of the lithospheric plate between latitudes 58°N to 59.5°N. The possibility of a third zone of subduction north of latitude 59.5°N between longitudes 139°W to 142°W is indicated.
Fault activity and sedimentation in a marine rift basin (Upper Jurassic, Wessex Basin, UK)

Shallow‐marine carbonates and siliciclastics of the Corallian Formation (Oxfordian–Early Kimmeridgian) accumulated on and around an intrabasinal high in the extensional Wessex Basin. Four sequences can be recognized. Sequences 1–3 accumulated under conditions of thermal subsidence on a ramp‐type margin. The initial sequence was siliciclastic. Highstand sedimentation in this sequence reflects the supply of sandy mud from a recently emergent intrabasinal high. During transgression and regression this muddy sediment was reworked into cleaner sandstone bodies by landward or basinward migrating zones of shoreface erosion. Carbonates dominate the second and third sequences when rising sea level increased the area of carbonate production and reduced siliciclastic input. Oolite bodies developed as both transgressive barrier bars and highstand sheets. The forth sequence formed during the activation of major normal faults. This caused the breakdown of the ramp system, and patterns of sediment accumulation were strongly controlled by tectonic subsidence patterns.
The Effect of Device Redundancy in Timeliness of Information

Emerging interaction-based Internet of Things (IoT) applications have stringent demand for timeliness, imposing critical challenges to the design of status update system. Using redundant devices to update the status of the same process is a promising way to improve timeliness, but this approach can result in out of order update arrivals, making it difficult to analyze timeliness. To that end, the present paper conducts a theoretical study toward the Age of Information (AoI) of a multi-queue status update system where multiple sensors observe one physical process and update a common monitor. Based on the stochastic hybrid systems method, the average AoI of the considered system is derived in closed form. The theoretical results are consistent with the simulation results, verifying the correctness of the theoretical analysis. It is shown that the logarithm of the average AoI is linearly decreasing with the logarithm of the number of sensors.
Observed and modeled tropospheric cold anomalies associated with sudden stratospheric warmings

Surface weather patterns related to 35 major sudden stratospheric warmings (SSWs) in 1958–2010 are analyzed based on reanalysis data. Similar analyses are conducted with data from seven stratosphere‐resolving Earth system models. The analyses are carried out separately for displacement and splitting SSWs. On the basis of the observational analysis, it is shown that in northern Eurasia, the cold anomalies linked to the SSWs tend to be stronger and more widespread before the central date of the SSWs than during the first 2 months after the event central dates. This is particularly true for the displacement events. The cold anomalies preceding the SSWs are coupled to atmospheric blocking events which trigger the SSWs. While the role of SSWs as important predictors of cold air outbreaks in the Northern Hemisphere is well recognized, our results indicate that the impact of the preceding blocking on near‐surface temperatures is, in fact, widely more significant than the downward impact of the SSWs. Thus, stratosphere‐troposphere coupling provides only limited predictability for cold air outbreaks in Eurasia. The models reproduce qualitatively well the typical large‐scale surface weather patterns following the SSWs, but they largely miss the cooling preceding the SSWs over Europe and western Siberia. Hence, the strongest modeled temperature anomalies related to the SSWs occur after the events. Moreover, the model results indicate that the tropospheric response to SSWs is stronger following split events. At the same time, many models simulate too few splitting SSWs.
Characterization of the far-red fluorescent probe MitoView 633 for dynamic mitochondrial membrane potential measurement

Introduction: MitoView 633, a far-red fluorescent dye, exhibits the ability to accumulate within mitochondria in a membrane potential-dependent manner, as described by the Nernst equation. This characteristic renders it a promising candidate for bioenergetics studies, particularly as a robust indicator of mitochondrial membrane potential (DYm). Despite its great potential, its utility in live cell imaging has not been well characterized. Methods: This study seeks to characterize the spectral properties of MitoView 633 in live cells and evaluate its mitochondrial staining, resistance to photobleaching, and dynamics during DYm depolarization. The co-staining and imaging of MitoView 633 with other fluorophores such as MitoSOX Red and Fluo-4 AM were also examined in cardiomyocytes using confocal microscopy. Results and Discussion: Spectrum analysis showed that MitoView 633 emission could be detected at 660 ± 50 nm, and exhibited superior thermal stability compared to tetramethylrhodamine methyl ester (TMRM), a commonly used DYm indicator, which emits at 605 ± 25 nm. Confocal imaging unequivocally illustrated MitoView 633’s specific localization within the mitochondrial matrix, corroborated by its colocalization with MitoTracker Green, a well-established mitochondrial marker. Furthermore, our investigation revealed that MitoView 633 exhibited minimal photobleaching at the recommended in vitro concentrations. Additionally, the dynamics of MitoView 633 fluoresce during carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP, a mitochondrial uncoupler)-induced DYm depolarization mirrored that of TMRM. Importantly, MitoView 633 demonstrated compatibility with co-staining alongside MitoSOX Red and Fluo-4 AM, enabling concurrent monitoring of DYm, mitochondrial ROS, and cytosolic Ca2+ in intact cells. Conclusion: These findings collectively underscore MitoView 633 as a superb molecular probe for the singular or combined assessment of DYm and other indicators in live cell imaging applications.
Attenuation of seismic waves in dry and saturated rocks; I, Laboratory measurements

The attenuation of compressional (P) and shear (S) waves in dry, saturated, and frozen rocks is measured in the laboratory at ultrasonic frequencies. A pulse transmission technique and spectral ratios are used to determine attenuation coefficients and quality factor (Q) values relative to a reference sample with very low attenuation. In the frequency range of about 0.1–1.0 MHz, the attenuation coefficient is linearly proportional to frequency (constant Q) both for P‐ and S‐waves. In dry rocks, Qp of compressional waves is slightly smaller than Qs of shear waves. In brine and water‐saturated rocks, Qp is larger than Qs. Attenuation decreases substantially (Q values increase) with increasing differential pressure for both P‐ and S‐waves.