Miracle-dz/UniFAR-FTUs huggingface dataset:
Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study

Aim: To investigate the efficacy and safety of micropulse laser trabeculoplasty (MLT) using a 577 nm yellow wavelength laser randomly assigned to either 1500 or 1000 mW in patients with primary open-angle glaucoma (POAG). Methods: A prospective, double-blinded study of POAG patients was performed in a single center. MLT treatment included a 577 nm micropulse laser (IRIDEX IQ 577TM, IRIDEX, Mountain View, CA, USA) to 360° of the trabecular meshwork at randomly assigned varying powers: 1500 mW in one eye (MLT 1500 group) and 1000 mW in the other (MLT 1000 group). Best-corrected visual acuity (BCVA), intraocular pressure (IOP), corneal central thickness (CCT), and endothelial cell count (ECC) were evaluated at baseline (T0), post-operative 1 h (T1), 24 h (T2), 1 month (T3), 3 months (T4), and 6 months (T5) after laser treatment. Topical medications were assessed pre-treatment and at T4. Results: Among the 18 eyes included, we achieved a success rate (IOP reduced > 20%) in 77% of sampled eyes. In particular, IOP reduced at T2 and T3 with both MLT 1500 and 1000 without any significant differences (IOP reduction 22.9% vs. 17.3%, respectively, MLT1500 vs. MLT1000 at T2). The IOP returned to baseline values at T4 and T5 in both groups, with a reduction in topical medications administered from 2.5 ± 1.1 to 2.0 ± 1.2 to the 1500 mW group and from 2.4 ± 1.0 to 1.9 ± 1.0 to the 1000 mW group. At 1 h post-laser treatment, a transient IOP spike was registered among the MLT1500 group. There were no differences in CCT and ECC at any timepoint according to the laser powers. Conclusions: Over a 6-month follow-up period, 577 nm MLT at either 1500 or 1000 mW reduces IOP, enabling a stable reduction in the number of topical medications required for patients treated for POAG without any significant difference in terms of effectiveness and safety.
Oral Palatability and Owners’ Perception of the Effect of Increasing Amounts of Spirulina (Arthrospira platensis) in the Diet of a Cohort of Healthy Dogs and Cats

Simple Summary Spirulina (Arthrospira platensis) is regarded as a functional food due to its valuable nutritional profile and components with potential antioxidant, anti-inflammatory, and immune-modulatory properties. However, the use of Spirulina in companion animals is still largely unexplored. Additionally, the palatability of nutraceuticals can be a primary factor in determining compliance with the protocol when they are used as complementary feed. The aim of this study was thus to assess the palatability and owners’ perception of the effects of increasing amounts of Spirulina tablets in client-owned dogs and cats for a 6-week-long trial. Overall, the animals well accepted the supplementation of Spirulina, with no significant side effect detected. Owners appeared willing to adopt dietary Spirulina supplementation in the future for their pets, especially owners of senior dogs. Abstract The nutraceutical supplementation of Spirulina (Arthrospira platensis) in dogs and cats has not yet been investigated. The aim of this study was to evaluate if the dietary supplementation of increasing amounts of Spirulina for 6 weeks is palatable to pets and to assess the owner’s perception of such supplementation. The owners of the 60 dogs and 30 cats that participated in this study were instructed to daily provide Spirulina tablets starting with a daily amount of 0.4 g, 0.8 g, and 1.2 g for cats as well as small dogs, medium dogs, and large dogs, respectively, and allowing a dose escalation of 2× and 3× every 2 weeks. The daily amount (g/kg BW) of Spirulina ranged from 0.08 to 0.25 for cats, from 0.06 to 0.19 for small-sized dogs, from 0.05 to 0.15 for medium-sized dogs, and from 0.04 to 0.12 for large-sized dogs. Each owner completed a questionnaire at the time of recruitment and the end of each 2-week period. No significant effect on the fecal score, defecation frequency, vomiting, scratching, lacrimation, general health status, and behavioral attitudes was detected by the owners’ reported evaluations. Most animals accepted Spirulina tablets either administrated alone or mixed with food in the bowl. Daily supplementation of Spirulina for 6 weeks in the amounts provided in this study is therefore palatable and well tolerated by dogs and cats.
Decreasing frequency but worsening mortality of acute respiratory failure secondary to AIDS-related Pneumocystis carinii pneumonia.

OBJECTIVE To describe changes in incidence and outcome of acute respiratory failure (ARF) due to AIDS-related Pneumocystis carinii pneumonia (PCP) at a tertiary care center over the 4-year period starting April 1, 1987 with reference to previously reported data from the preceding 6 years. METHODS All patients admitted to St. Paul's hospital with a diagnosis of AIDS-related PCP during the study period were reviewed with regard to diagnostic, clinical, therapeutic, and outcome variables. RESULTS A total of 456 episodes of PCP were diagnosed during the study period. These were compared against 127 cases diagnosed between 1981 and 1987. The frequency of hospitalization for PCP decreased to 78% in 1987 to 1991 from 100% in 1981 to 1987 (p < or = 0.001). A similar decreasing trend was observed with regard to the incidence of PCP-related ARF that declined from 21% in 1981 to 1987 to 9% in 1987 to 1991 (p = 0.009). Despite this, overall PCP-related mortality remained stable at 12% in 1981 to 1987 and 9% in 1987 to 1991 (p = 0.26). The proportion of patients with PCP-related ARF who received mechanical ventilation decreased from 89% in 1981 to 1987 to 64% in 1987 to 1991 (p < 0.001). Despite this, the case fatality rate among mechanically ventilated patients increased from 50% in 1981 to 1987 to 89% in 1987 to 1991 (p = 0.003). These changes were associated with a significant change in the pattern of use of corticosteroids as adjunctive therapy for AIDS-related PCP. In 1985 to 1986, nearly 100% of patients admitted to the ICU received corticosteroids only after admission to the ICU, following the development of ARF. In contrast, in 1989 to 1990, 50% of patients were admitted to the ICU already receiving systemic corticosteroids. The rise in the proportion of patients receiving corticosteroids prior to ICU admission between these two intervals was statistically significant (p = 0.017). CONCLUSION Our data show a decreasing frequency but a worsening mortality of ARF secondary to AIDS-related PCP. We conclude that ARF secondary to AIDS-related PCP developing despite maximal therapy, including adjunctive corticosteroids, carries a dismal prognosis.
Relationship between Health-promoting practices and the Health-related Quality of Life among Saudi University Students after the COVID-19 Pandemic Lockdown: Cross-sectional Study

Promoting healthy living activities among university students is acknowledged as an essential component in health maintenance and improvement. This study aims to determine the extent to which Saudi undergraduate students are involved in health-promoting practices after the COVID-19 pandemic lockdown. It also investigates how the health-related quality of life (QOL) could be predicted from sociodemographics and health-promoting practices. This study adopted a descriptive correlational design and a convenience sampling method to recruit 542 Saudi students from 5 governmental universities in multiple Saudi regions between October and December 2022. University students were asked to complete an online survey consisting of sociodemographics, the health-promoting lifestyle profile II (52 Items, 4 points Likert scale), and the WHOQOLscale (26 Items, 5 points Likert scale). In the health-promoting subscales, participants ranked best in spiritual growth (M = 2.79) but worst in physical activity (M = 1.82). Regarding the QOL subscales, participants scored the highest in social relationships (M = 14.32) and the lowest in psychological health (M = 11.36). Multiple linear regression revealed that 19% of the variance in the QOL was explained mainly by health-promoting variables, in which physical activity (β = .20, p < .001) was the strongest predictor. In addition, family income (β = -.14, p < .01), nutrition (β = .12, p < .05), stress management (β = .11, p < .05), and spiritual growth (β = .14, p < .05) were also significant predictors of QOL. Physical activity, nutrition, spiritual growth, and stress management have been found helpful in improving the QOL of Saudi students. Therefore, universities should consider planning curricula and establishing activities that encourage involvement in health-promoting activities.
K/sup 0/-K-bar/sup 0/ mixing in the six-quark model

Using the leading-logarithm approximation, strong-interaction corrections to K/sup 0/-K-bar/sup 0/ mixing in the six-quark model are computed in quantum chromodynamics. The full calculation involving the mixing of eight operators at some stages is done, as well as an approximate, much simpler calculation. Numerically, the exact and approximate results agree to high accuracy and both show that the corrections to the real and imaginary parts can be large. How to obtain the free-quark limit of these and other results is shown explicitly.
Classical and Quantum Aspects of Anisotropic Cosmology

The idea that our observable Universe may have originated from a quantum tunneling event out of an eternally inflating false vacuum state is a cornerstone of the multiverse paradigm. Modern theories that are considered as an approach towards the ultraviolet-complete fundamental theory of particles and gravity, such as the various types of string theory, even suggest that a vast landscape of different vacuum configurations exists, and that gravitational tunneling is an important mechanism with which the Universe can explore this landscape. The tunneling scenario also presents a unique framework to address the initial conditions of our observable Universe. In particular, it allows to introduce deviations from the cosmological concordance model in a controlled and well-motivated way. These deviations are a central topic of this work. An important feature in most of the theories mentioned above is the presumed existence of additional space dimensions in excess of the three which we observe in our every-day experience. It was realized that these extra dimensions could avoid our detection if they are compactified to microscopic length scales far beyond the reach of current experiments. There also seem to be natural mechanisms available for dynamical compactification in those theories. These typically lead to a vast landscape of different vacuum configurations which also may differ in the number of macroscopic dimensions, only the total number of dimensions being determined by the theory. Transitions between these vacuum configurations may hence open up new directions which were previously compact, spontaneously compactify some previously macroscopic directions, or otherwise re-arrange the configuration of compact and macroscopic dimensions in a more general way. From within the bubble Universe, such a process may be perceived as an anisotropic background spacetime - intuitively, the dimensions which open up may give rise to preferred directions. If our 3 + 1 dimensional observable Universe was born in a process as described above, one may expect to find traces of a preferred direction in cosmological observations. For instance, two directions could be curved like on a sphere, while the third space direction is flat. Using a scenario of gravitational tunneling to fix the initial conditions, I show how the primordial signatures in such an anisotropic Universe can be obtained in principle and work out a particular example in more detail. A small deviation from isotropy also has phenomenological consequences for the later evolution of the Universe. I discuss the most important effects and show that backreaction can be dynamically important. In particular, under certain conditions, a buildup of anisotropic stress in different components of the cosmic fluid can lead to a dynamical isotropization of the total stress-energy tensor. The mechanism is again demonstrated with the help of a physical example.
Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic Syndrome

Idiopathic nephrotic syndrome (INS) is a chronic glomerular disease in children, characterized by severe proteinuria, hypoalbuminemia, and/or presence of edema and hyperlipidemia. The pathogenesis, however, has not been yet established. The clinical course of the disease is characterized by frequent relapses. Interleukin-15 (IL-15) is a pro-inflammatory cytokine, that apart from its involvement in the immune system, was found to be playing a vital role in various cells’ functioning, including renal tissue. It is desirable to look for new predictors of INS. Our study aimed to evaluate IL-15 as a potential marker in the early diagnosis of the disease. The cohort participating in the study consisted of patients hospitalized in Clinical Hospital No. 1 in Zabrze, from December 2019 to December 2021, including study group with INS (n = 30) and control group (n = 44). Results: The concentration of IL-15 in both serum and urine was significantly elevated in patients with INS, compared to healthy controls. The cytokine might serve as a marker of the disease, however, further research on larger study groups is needed.
Study on Application of Iron Tailings in Cement Stabilized Macadam

With the rapid development of ferrous metallurgy, the production of iron tailings as waste after beneficiation is increasing. Due to the shortage of natural stone in road construction, iron tailings can be used as an alternative material to natural stone in semi-rigid bases. In order to study the feasibility of application of cement stabilized iron tailings (CSIT) in semi-rigid base, unconfined compressive strength (UCS), indirect tensile strength (ITS) and cyclic freeze-thaw tests were carried out on cement stabilized iron tailings (CSIT). The gradation composition and cement content were selected as influencing factors. The results show that under the condition of the same cement content, the UCS and ITS of CSIT are proportional to the particle size in the mixture. In CSIT with the same gradation, the mechanical properties increase with the increase of cement content; CSM-40(B) has a higher UCS and CSM-40(C) has a higher ITS, the frost resistance coefficient of CSIT increases with the increase of cement content and the tendency of frost resistance coefficient decreases with the increase of cement content. The frost resistanceofCSM-40 (B) is better than that of CSM-40 (C) for the same cement content. Therefore, for the use of iron tailings in CSM, a suitable gradation composition and cement content should be selected.
Mangrove Trees Outperform Saltmarsh Grasses in Building Elevation but Collapse Rapidly Under High Rates of Sea‐Level Rise

Mangrove trees are invading saltmarshes at subtropical ecotones globally, but the consequences of this vegetation shift for ecosystem sustainability remain unknown. Using the Coastal Wetland Equilibrium Model (CWEM) to simulate vegetation survival and sediment accretion, we predict that black mangroves, Avicennia germinans, can build soil elevation by 8 mm yr−1, four times greater than saltmarshes at the same site, a finding that is broadly consistent with field measurements of elevation change. Mangroves build elevation more rapidly than saltmarshes by producing much greater live and labile belowground biomass, but when mangroves drown, they abruptly lose elevation due to the large volume of quickly decomposing necromass following flood‐induced mortality. Under certain conditions, young mangroves can accumulate root mass faster than mature trees and, therefore, gain elevation more rapidly, but neither saltmarshes nor mangroves of any age survived a centenary sea‐level increase of 100 cm. The acceleration of sea‐level rise that coastal marshes are encountering raises the question of how coastal wetlands should be optimally managed and these results provide managers with predictive information on wetland building capacity of mangroves versus marshes.
Rain gauge and disdrometer measurements during the Keys Area Microphysics Project (KAMP)

Abstract Four impact disdrometers and 27 tipping bucket rain gauges were operated at 11 different sites during August and September 2001, as part of the Keys Area Microphysics Project. The rain gauge and disdrometer network was designed to study the range dependency of radar calibration and rainfall verification in tropical storms. The gauges were collocated at eight sites, while three to five gauge clusters were deployed at three sites. Four disdrometers were also collocated with rain gauges. Overall the experiment was quite successful, although some problems did occur including flooding of gauge loggers, vandalism, and excessive noise at disdrometer sites. Both a south-to-north and east-to-west rainfall gradient was observed, whereby the gauges on the western and northern sides of the Lower Keys recorded more rainfall. Considering the campaign-long rain accumulations, collocated gauges agreed well, with differences generally less than 2%, except for one gauge cluster where the rain accumulation differen.
Post‐glacial range formation of temperate forest understorey herbs – Insights from a spatio‐temporally explicit modelling approach

Abstract Aim Our knowledge of Pleistocene refugia and post‐glacial recolonization routes of forest understorey plants is still very limited. The geographical ranges of these species are often rather narrow and show highly idiosyncratic, often fragmented patterns indicating either narrow and species‐specific ecological tolerances or strong dispersal limitations. However, the relative roles of these factors are inherently difficult to disentangle. Location Central and south‐eastern Europe. Time period 17,100 BP – present. Major taxa studied Five understorey herbs of European beech forests: Aposeris foetida, Cardamine trifolia, Euphorbia carniolica, Hacquetia epipactis and Helleborus niger. Methods We used spatio‐temporally explicit modelling to reconstruct the post‐glacial range dynamics of the five forest understorey herbs. We varied niche requirements, demographic rates and dispersal abilities across plausible ranges and simulated the spread of species from potential Pleistocene refugia identified by phylogeographical analyses. Then we identified the parameter settings allowing for the most accurate reconstruction of their current geographical ranges. Results We found a largely homogenous pattern of optimal parameter settings among species. Broad ecological niches had to be combined with very low but non‐zero rates of long‐distance dispersal via chance events and low rates of seed dispersal over moderate distances by standard dispersal vectors. However, long‐distance dispersal events, although rare, led to high variation among replicated simulation runs. Main conclusions Small and fragmented ranges of many forest understorey species are best explained by a combination of broad ecological niches and rare medium‐ and long‐distance dispersal events. Stochasticity is thus an important determinant of current species ranges, explaining the idiosyncratic distribution patterns of the study species despite strong similarities in refugia, ecological tolerances and dispersal abilities.
Promising Therapeutic Impact of Immune Checkpoint Inhibitors in Type II Endometrial Cancer Patients with Deficient Mismatch Repair Status

Type II endometrial cancer (EC) is responsible for most endometrial cancer-related deaths due to its aggressive nature, late-stage detection, and high tolerance to standard therapies. Thus, novel treatment strategies for type II EC are imperative. For patients with mismatch repair-deficient (dMMR) tumors, immunotherapy with immune checkpoint inhibitors represents a promising therapeutic strategy. However, the prevalence of dMMR tumors in type II EC patients remains unclear. In this study, using immunohistochemistry, we evaluated the expression of mismatch repair (MMR) proteins, tumor-infiltrating lymphocytes (CD8+), and immune checkpoint molecules (PD-L1) in 60 patients with type II EC (16, 5, 17, and 22 were endometrioid G3, serous, de-differentiated, and carcinosarcoma cases, respectively) to investigate the therapeutic effect of immune checkpoint inhibitors. Approximately 24 cases (40%) had a loss of MMR protein expression. The positivity rate of CD8+ (p = 0.0072) and PD-L1 (p = 0.0061) expression was significantly associated with the dMMR group. These results suggest immune checkpoint inhibitors (anti-PD-L1/PD-1 antibodies) could effectively treat type II EC with dMMR. The presence of dMMR might be a biomarker for a positive response to PD-1/PD-L1 immunotherapy in type II EC.
An Essay in Honor of Adolf Grünbaum’s Ninetieth Birthday: A Reexamination of Zeno’s Paradox of Extension

We suggest that, far from establishing an inconsistency in the standard theory of the geometrical linear continuum, Zeno’s Paradox of Extension merely establishes an inconsistency between the standard theory of geometrical magnitude and a misguided system of length measurement. We further suggest that our resolution of Zeno’s paradox is superior to Adolf Grünbaum’s now standard resolution based on Lebesgue measure theory.
Distributed Policy Gradient with Heterogeneous Computations for Federated Reinforcement Learning

The rapid advances in federated learning (FL) in the past few years have recently inspired federated reinforcement learning (FRL), where multiple reinforcement learning (RL) agents collaboratively learn a common decision-making policy without exchanging their raw interaction data with their environments. In this paper, we consider a general FRL framework where agents interact with different environments with identical state and action spaces but different rewards and dynamics. Motivated by the fact that agents often have heterogeneous computation capabilities, we propose a Federated Heterogeneous Policy Gradient (FedHPG) algorithm for FRL, where agents can use different numbers of data trajectories (i.e., batch sizes) and different numbers of local computation iterations for their respective PG algorithms. We characterize performance bounds for the learning accuracy of FedHPG, which shows that it achieves a learning accuracy ∊ with sample complexity of $O$ (1/∊2), which matches the performance of existing RL algorithms. The results also show the impacts of local iteration numbers and batch sizes for iteration on the learning accuracy. We also extend FedHPG to heterogeneous policy gradient variance reduction (FedHPGVR) algorithm based on the variance reduction method, and analyze the convergence of this algorithm. The theoretical results are verified empirically for benchmark RL tasks.