Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunoinformatic design of multi epitopes peptide-based universal cancer vaccine using matrix metalloproteinase-9 protein as a target

Background Cancer remains a major public health hazard despite the extensive research over the years on cancer diagnostic and treatment, this is mainly due to the complex pathophysiology and genetic makeup of cancer. A new approach toward cancer treatment is the use of cancer vaccine, yet the different molecular bases of cancers reduce the effectiveness of this approach. In this work we aim to use matrix metalloproteinase-9 protein (MMP9) which is essential molecule in the survival and metastasis of all type of cancer as a target for universal cancer vaccine design. Method reference sequence of matrix metalloproteinase-9 protein was obtained from NCBI databases along with the related sequence, which is then checked for conservation using BioEdit, furthermore the B cell and T cell related peptide were analyzed using IEDB website. The best candidate peptide were then visualized using chimera software. Result Three Peptides found to be good candidate for interactions with B cells (SLPE, RLYT, and PALPR), while ten peptides found as a good target for interactions with MHC1 (YRYGYTRVA, YGYTRVAEM, YLYRYGYTR, WRFDVKAQM, ALWSAVTPL, LLLQKQLSL, LIADKWPAL, KLFGFCPTR, MYPMYRFTE, FLIADKWPA) with world combined coverage of 94.77%. In addition, ten peptides were also found as a good candidates for interactions with MHC2 (KMLLFSGRRLWRFDV, GRGKMLLFSGRRLWR, RGKMLLFSGRRLWRF, GKMLLFSGRRLWRFD, TFTRVYSRDADIVIQ, AVIDDAFARAFALWS, FARAFALWSAVTPLT, MLLFSGRRLWRFDVK, GNQLYLFKDGKYWRF, NQLYLFKDGKYWRFS), with world combined coverage of 90.67%. CONCLUSION 23 peptide-based vaccine was designed for use as a universal cancer vaccine which has a high world population coverage for MHC1(94.77%) and MHC2 (90.67%) related alleles.
Risk Factors and Complications Associated with Tuberculosis in Pregnancy and Neonates in Limpopo Province, South Africa

Abstract Basic Antenatal Care (BANC) was introduced in Primary Health Care (PHC) facilities in order to reduce the burden of consistently high maternal and neonatal mortality rate. The study identified risk factors and described complications associated with TB in pregnant mothers and neonates. A quantitative and descriptive research design was used to collect data at ten selected hospitals in Limpopo Province. Sample size of 150 Medical maternity case records was randomly selected. Records were assessed and analysed using checklist. The findings revealed socio-economic problems such as poverty and HIV/AIDS infections as the major risk factors associated with TB in pregnancy. Complications such as eclampsia and low birth weight in mothers and neonates were revealed. There is higher rate of HIV/AIDS infection among pregnant mothers with TB. Emphasis needs to be placed on strengthening the integration and implementation of PMTCT, TB/HIV in BANC services, and continue to build on past achievements.
Sensitivity of snow models to the accuracy of meteorological forcings in mountain environment

Snow models are usually evaluated at sites providing high-quality meteorological data, so that the uncertainty in the meteorological input data can be neglected when assessing model performances. However, high-quality input data are rarely available in mountain areas and, in practical applications, the meteorological forcing used to drive snow models is typically derived from spatial interpolation of the available in situ data or from reanalyses, whose accuracy can be considerably lower. In order to fully characterize the performances of a snow model, the model sensitivity to errors in the input data should be quantified. In this study we test the ability of six snow models to reproduce snow water equivalent, snow density and snow depth when they are forced by meteorological input data with gradually lower accuracy. The SNOWPACK, GEOTOP, HTESSEL, UTOPIA, SMASH and S3M snow models are forced, first, with high-quality measurements performed at the experimental site of Torgnon, located at 2160 m a.s. l. in the Italian Alps (control run). Then, the models are forced by data at gradually lower temporal and/or spatial resolution, obtained by (i) sampling the original Torgnon 30 min time series at 3, 6, and 12 h, (ii) spatially interpolating neighbouring in situ station measurements and (iii) extracting information from GLDAS, ERA5 and ERA-Interim reanalyses at the grid point closest to the Torgnon site. Since the selected models are characterized by different degrees of complexity, from highly sophisticated multi-layer snow models to simple, empirical, single-layer snow schemes, we also discuss the results of these experiments in relation to the model complexity. The results show that, when forced by accurate 30 min resolution weather station data, the single-layer, intermediatecomplexity snow models HTESSEL and UTOPIA provide similar skills to the more sophisticated multi-layer model SNOWPACK, and these three models show better agreement with observations and more robust performances over different seasons compared to the lower-complexity models SMASH and S3M. All models forced by 3-hourly data provide similar skills to the control run, while the use of 6and 12-hourly temporal resolution forcings may lead to a reduction in model performances if the incoming shortwave radiation is not properly represented. The SMASH model generally shows low sensitivity to the temporal degradation of the input data. Spatially interpolated data from neighbouring stations and reanalyses are found to be adequate forcings, provided that temperature and precipitation variables are not affected by large biases over the considered period. However, a simple bias-adjustment technique applied to ERA-Interim Published by Copernicus Publications on behalf of the European Geosciences Union. 4062 S. Terzago et al.: Snow model sensitivity to input accuracy temperatures allowed all models to achieve similar performances to the control run. Regardless of their complexity, all models show weaknesses in the representation of the snow density.
Formalizing small and women-led businesses in West Africa: major approaches and their limitations

Abstract This article is about policies designed for the small informal businesses in Africa, focusing on women-led enterprises, in order to assist them grow and eventually formalize. Following a thorough discussion on various modalities of support to such businesses, we underscore, the role of skills development in the areas of vocational training and “soft skills” development as an important way of empowering small and female entrepreneurs. We also discuss various financing mechanisms beyond standard microfinance schemes to improve uptake and boost investment and innovation among this category of firms.
M1 M2 macrophage expression in menstrual blood flakes of women with endometriosis

Objectives: to measure and prove the increase of panmacrophage, macrophages M1 and M2 expression and decrease of ratio of M1/M2 in menstrual blood flakes of women with endometriosis. Materials and Methods: This study was a cross sectional observational analytic study conducted on 30 subjects with endometriosis and non-endometriosis. Immunohistochemical staining was done on a sample of menstrual blood flakes of subjects study who were taken at the second or third day of menstrual cycles with CD68 and CD163 antibody to measure the expression of panmacrophage and M2 macrophages. Expression of M1 macrophages is the approach of a reduction expression of panmacrophage with M2 macrophages. Results: Expression of M1, M2 and the ratio M1/M2 in the both of groups had a normal distribution then continued by independent t-test with one-tailed α (0.05). Probability was considered statistically significant at p <0.05 with a confidence interval of 95%. Based on the statistical result, Mφ macrophage expression in endometriosis and control group amounted to 3.62 ± 0.50 and 2.80 ± 0.64 (p =0.0005) with non parametric test. The expression of M1 macrophages in endometriosis group and non endometriosis were respectively 1.40 ± 0.35 and 1.33 ± 0.40 (p =0.3005) and the expression of M2 in both of group, respectively of 2.23 ± 0.41 and 1.47 ± 0.36 (p =0.0005). The ratio of M1/M2, the endometriosis group and non endometriosis, respectively of 0.65 ± 0.20 and 0.92 ± 0.24 (p =0.0015). Conclusion: this study were significant increased in the panmacrophage Mφ, M2 macrophages expression on a woman's menstrual blood flakes endometriosis and significant decreased in ratio M1/M2 in the woman's menstrual blood flakes endometriosis.
Comprehensive behavioural model for an electronic amplifier used in an optical communications systems

Faculty of Engineering & Applied Science Communications & Signal Processing Department Master of Applied Science in Telecommunications Engineering by Patricio Fuentes Ugartemendia Correctly modelling the behaviour of power amplifiers to include the nonlinear aspects of their response has been a matter of interest in the fields of electronic and wireless communications for a considerable amount of time. Throughout the last decades, numerous techniques that succeed in accurately representing these nonlinearities and that provide ways to reduce their impact on system performance have been derived. An essential application of these techniques is the construction of amplifier models that can be used to obtain a deeper understanding of the phenomena that make these devices more or less nonlinear. These models have been used in numerous scenarios to comprehend and devise ways to mitigate the impact of nonlinearity in the response of many amplifiers. However, ultra-broadband RF electronic drive amplifiers used in optical communications environments represent a small niche in which extensive derivation of these amplifier models has not yet been accomplished. In this thesis, a device-specific behavioural model for one such electronic drive amplifier will be constructed based on existing modelling techniques and extensive lab measurements. In addition, changes in the performance of a communications system when these behavioural models are integrated within it will also be studied. Ultimately, this thesis will strive to determine the specific phenomena that are linked to the nonlinearity present in the response of an ultra-broadband RF electronic drive amplifier and how variation of these factors affects the behaviour of this device.
Effect of TV advertising on energy intake of Georgian children: Results of an experimental study

BACKGROUND: Food advertising has been hypothesized to be related with increased consumption of energy-dense food in children, resulting in weight gain. Several studies have been conducted in this field, but little is known about children living in Eastern Europe countries. OBJECTIVE: The aim of this study was to investigate the influence of TV viewing and TV advertising on energy intake in Georgian children. METHODS: Sixty children aged 3–11 were recruited in a school of Tbilisi (Georgia) and were exposed, in an experimental setting, to different levels of TV and TV advertising: “no exposure to TV”, “exposure to TV without advertising”, “exposure to TV and one advertising”, “exposure to TV and two advertisings”, “exposure to TV and three advertisings”. Children were asked to eat ad libitum for 20 minutes a chocolate-based snack during the afternoon break. RESULTS: Enrolled children showed a median value of energy intake of 220.72 kcal, corresponding to a median of 2 snacks for each child. No significant association between energy intake and TV viewing/TV advertising was found, even after adjustment for potential confounding factors. CONCLUSION: Findings from the present experimental study showed no association of TV viewing and TV advertising with energy intake in a sample of Georgian children.
Formation of Language Competence: Modern Issues and Strategies in the Area of Cross-Cultural Communication

In the framework of globalisation, the development of cross-cultural communication skills is of high interest. However, there is no due attention paid to the development of intercultural language competence in all universities as well as the possibility to share it directly with native interlocutors of the other culture. The objective of the article is to define the critical complexities in the area of cross-cultural communication among those who study a foreign language. Another objective is to elaborate recommendations that will enable the solution of the issues in the area of cross-cultural communication within up-to-date education. As a result, the researchers’ have organised and carried out the survey among 650 linguistic students of the 4th course from four largest Russian higher educational institutions (Peoples’ Friendship University of Russia, Higher School of Economics, Moscow State Institute of International Relations, and Moscow State University). The outcomes of the research can be used in future as the basis for the development of cross-cultural communication for university students, which should have cross-cultural competence.
Factors affecting quality of life among elderly living in nursing homes

Introduction and purpose: Understanding factors affect quality of life at old age is considered as an important social issue particularly when population is ageing. Acquiring such information play a vital role in enhancing quality of life among elderly. Therefore, this study aimed to assess factors affecting quality of life in nursing homes-residing elderly people. Materials and Methods: This cross-sectional study included 73 female elderly living in the nursing homes of Khoramshahr and Ahvaz city. Data were collected using two questionnaires including demographic characteristics and the SF-36 questionnaire. Data analysis was done by SPSS 13. Findings: Results from the present study showed that mean age of participants was 52.75 (S.D= 11.39) years old which ranged from 60 to 102 years. There was a significant association between quality of life and education (P less-than 0.05), age (P=0.03), chronic disease (P less-than 0.01) and place of residence (P=0.4). However, no significant association was observed between quality of life and marital status (P=0.62), length of stay in nursing home (P=0.4) and income (P=0.3). Conclusion: In general, elderly living in nursing homes reported lower quality of life compared to community-dwelling elderly. Therefore, nursing homes are recommended to create more caring and compassionate environment that is similar to elderlys own home. In addition, family members and friends are suggested to visit elderly residing in nursing homes on a regular basis in order to improve their quality of life.
Exploring Polarimetric Phase of Microwave Backscatter from Typha Wetlands

Abstract Despite their natural and societal importance, wetlands are becoming increasingly threatened. The goal of this study is to investigate the potential of polarimetric synthetic aperture radar (SAR) for monitoring one important vegetation constituent of wetlands: Typha. An idealized cylindrical scattering model is developed to portray double bounce microwave scattering from Typha stalks. Then a thin cylinder Brewster angle is introduced; relating the co-pol phase difference (CPD) of Typha to its relative permittivity. Full polarization Radarsat-2 data were acquired for a variety of dates and incidence angle ranges in order to validate the scattering model. The dependence of CPD on incidence angle is found to be consistent with the model. The evolution of CPD with seasonal senescence was also investigated. Despite some agreement with expected trends in vegetation moisture, there are anomalies that remain unexplained; possibly due to ecosystem change. This suggests the need for radar scatterometer experiments in a controlled environment to better explore the dependence of CPD on incidence angle and seasonal change. Last, cross-pol phase difference (XPD) histograms support other research in demonstrating the existence of coherent depolarization in Typha scattering. Additional modeling, entailing the detailed structure of the vegetation, will be necessary to understand this behavior.
Strengthening of Students’ Solidarity Character Education in the Digital Era Through Islamic Individual Building for Junior Students

: Education has an important role in building students' solidarity character in faced technology and information development. This research attempted to analyze the solidarity characteristic strengthening concept as an effort to overcome the negative impact of information and technology development in the digital era toward junior high school students through Islamic Individual Buiding in SMP IT Nur Hidayah Surakarta. This research applied a qualitative research design namely case study for grades seven and eight. Based on the analysis result of the interview, observation, and documentation study, it was found that the activity of Islamic Individual Building as an effort to strengthen the students’ solidarity character done by SMPIT Nur Hidayah applied peer approach under teacher’s guidance. The method used wa s mentoring group discussion which emphasized the forming of social caring behavior, respecting others and good teamwork. The students' mentoring group was created at each grade guided by the teacher. The students’ mentoring grouping was done randomly based on the test result, spoken or written.
Understanding self-efficacy and performance of salespersons in Islamic banking

This study aims to investigate the relationship between organization image, awareness effort, customer demandingness, self-efficacy and self-rated performance among salespersons of Islamic banking products in the UAE. It also explores the mediating role of awareness effort and self-efficacy, using a theoretical framework derived from social cognitive theory. ,Data are collected by surveying salespersons in a mixed bank (a conventional bank with an Islamic banking department) in the UAE. The researcher uses structural equation modeling to analyze the data. ,The research concludes that customer demandingness positively affects awareness effort, awareness effort positively affects self-efficacy, self-efficacy positively affects performance and image positively affects salespersons’ self-efficacy and performance. Furthermore, the study highlights the mediating role of awareness effort and self-efficacy in the model. ,The sample consists of 217 salespersons working in the same bank, covering three cities in the UAE. Hence, the rest of the country is not included. ,The study shows the importance of awareness efforts in achieving better performance. It also demonstrates the importance of addressing customer requirements in the banking environment. Furthermore, it illuminates the role of organization image in enforcing salespersons’ self-efficacy and performance. ,The paper sheds a light on salespersons’ personalities and the factors that reinforce their performance and self-efficacy. ,The research is an empirical study that addresses the relationship between performance, self-efficacy, image, awareness effort and customer demandingness in Islamic banking in the UAE.
LOWER-LIMB PROSTHESES

This CPB has been revised to note that protective outer surface covering systems (L5962, L5964, and L5966) are specialized covers intended to be worn over an existing prosthesis. They are considered medically necessary for members who have special needs for protection against unusually harsh environmental situations where it is necessary to protect the lower limb prosthesis beyond the level of protection that is afforded by covers described by HCPCS codes L5704 L5707. They are not for cosmetic or convenience reasons, or for everyday usage in a typical environment. Protective outer surface coverings are different from the covering that is already reimbursed as part of L5704 L5707. When billing for the protective outer surface covering systems (L5962, L5964 and L5966), information regarding the type of protective cover provided (i.e., manufacturer name, make, model or type) must be included in practitioner’s notes in order to ensure correct coding.
Bacterial Contamination of Hospital Surfaces According to Material Make, LastTime of Contact and Last Time of Cleaning/Disinfection

Hospital cleaning and disinfection is the hallmark of infection control, over the past decade substantial scientific evidences has accumulated indicating that contamination of environmental surfaces in hospital rooms play an important role in the transmission of several key healthcare-associated pathogens. A cross-sectional study of indoor surfaces at paediatric wards of the university of Ilorin Teaching hospital (UITH) was carried out to determine the pattern of bacterial contamination of surfaces according to material make of surfaces, last time of contact and last time of cleaning and disinfection. Eight common surfaces (bed rails, bed lockers, radiant warmers, incubators, trolleys, medical tables, door handle and wash sinks) which patients, patients relative and healthcare provider often interact with within daily cleaning that were made from different materials (Aluminium, ceramic, plastic and wood) was sampled. The pattern of contaminants according to the material make show a statistical significance with P-value=0.0044. S. aureus was the predominant contaminants on aluminium surfaces, Klebsiella pneumoniae and A. baumannii were found to be the major contaminant isolated from ceramic surfaces while A. baumannii was the predominant contaminant of wooden surfaces sampled. Pattern according to the last time of contact show a statistical significance with P-value=0.0043. surfaces occupied by patient`s was largely contaminated. Bacterial contamination pattern according to the time lapse of cleaning or disinfection: surfaces that had been cleaned for greater 4 h prior to sample collection were found to have been contaminated with 86.3% of the isolates. Surfaces that were cleaned or disinfected less than 2 h prior to sample collection remained largely uncontaminated. Enhanced cleaning, the use of no-touch methods for terminal room disinfection, and potentially the use of self-disinfecting surfaces may aid in reducing health care associated infections.
The Common Complications and Comorbidities among Saudi Diabetic Patients in Northern Saudi Arabia

Background: Diabetes mellitus (DM), is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period with great harmful consequences, including cardiovascular and neurological complications, diabetic retinopathy, and diabetic nephropathy. Therefore, the objective of this study was to find out the common complications and comorbidities among diabetic Saudi patients in Northern Saudi Arabia. Methodology: Records of 50 diabetic patients were retrieved from King Khalid Hospital, Hail, Saudi Arabia. Different complications and comorbidities were documented and investigated. Results: Peripheral neuropath, retinopathy, diabetic septic foot, and amputation were identified among 40%, 38%, 14%, and 4%, correspondingly. Out of the 50 patients, 12 (24%), 18 (36%) and 8 (16%) were detected with thyroid diseases, dyslipidemia and renal complications, respectively. Conclusion: Hypertension, peripheral neuropathy, dyslipidemia, retinopathy, kidney complications and diabetic septic food represent the major complications and/or comorbidities among diabetic Saudi patients in northern Saudi Arabia. These complications and/or comorbidities must be well thought-out in epidemiological studies, so as to display disease burden and quality of diabetes care.