Miracle-dz/UniFAR-FTUs huggingface dataset:
The association between smartphone use and sleep quality, psychological distress, and loneliness among health care students and workers in Saudi Arabia

Background The use of smartphones among the general public and health care practitioners, in particular, is ubiquitous. The aim of this study was to investigate the relationship between smartphone addiction and sleep quality, psychological distress, and loneliness among health care students and workers in Saudi Arabia. Methods This cross-sectional study used an online questionnaire to collect data on smartphone addiction, sleep quality, psychological distress, and loneliness as well as demographic information. Results A total of 773 health care students and workers participated in the study, with an average age of 25.95 ± 8.35, and 59.6% female participants. The study found a positive significant association between smartphone addiction and psychological distress (F(1,771) = 140.8, P < 0.001) and emotional loneliness (F(1,771) = 26.70, P < 0.001). Additionally, a significant negative association between smartphone addiction and sleep quality was found (F(1,771) = 4.208, P = 0.041). However, there was no significant relationship between smartphone addiction and social loneliness (F (1,771) = 0.544, P < 0.461). Conclusion These findings suggest that smartphone addiction has a negative impact on psychological distress, sleep quality, and emotional loneliness among health care students and workers. It is important to promote strategies to reduce smartphone dependency in order to avoid the harmful consequences of smartphone addiction.
Nonlinear Oscillations in Rectangular Tanks

A nonlinear, dispersive, dissipative model is developed to describe the fluid motion in a rectangular tank which is moved by an oscillatory and transient translational motion. A linear model for this motion is also presented. Experiments conducted indicate that for a continuous excitation at or near a resonant mode of oscillation, the linear theory becomes inadequate and the nonlinear, dispersive, dissipative theory must be used. For a transient excitation, the validity of the linear theory is found to depend on the magnitude of the Stokes parameter.
Effects of Long-acting Injectable 3-Monthly Paliperidone Palmitate on the Clinical and Social Performance of Patients with Schizophrenia

Objective To investigate the effects of long-acting injectable 3-monthly paliperidone palmitate on the clinical and social functioning of patients with schizophrenia. Methods This study enrolled patients with schizophrenia receiving long-acting injectable 1-monthly paliperidone palmitate for at least 4 months and who subsequently received 3-monthly paliperidone palmitate. Accordingly, 418 patients were followed up for 24 weeks. Their clinical symptoms and social functioning were measured using the Clinical Global Impression-Severity of Illness and Personal and Social Performance scales. Results The Personal and Social Performance total score was significantly higher after 3-monthly paliperidone palmitate treatment than at baseline (baseline vs. week 24 54.3 ± 18.0 vs. 61.0 ± 14.5 [mean ± standard deviation]; p < 0.001; Wilcoxon signed-rank test); the proportion of patients in the mildly ill group (scores 71−100) also increased significantly (baseline vs. week 24 16.5% vs. 20.6%; p < 0.001; McNemar-Bowker test). The mean Clinical Global Impression-Severity of Illness score decreased significantly (baseline vs. week 24 3.7 ± 1.0 vs. 3.4 ± 0.9; p < 0.001; Wilcoxon signed-rank test), as did the proportion of patients in the severely ill group (baseline vs. week 24 4.1% vs. 2.1%; p < 0.001; McNemar-Bowker test). Conclusion Continuous 3-monthly paliperidone palmitate treatment significantly enhances the personal and social performance of patients with schizophrenia and reduces the proportion of those with severe illness. These findings suggest that long-acting injectable antipsychotic administration at intervals longer than 1 month might improve the social functioning of and promote return to activities of daily living in patients with schizophrenia.
Syringic acid Attenuates Oxidative Stress in Plasma and Peripheral Blood Mononuclear Cells of Patients with Acute Myeloid Leukemia

Abstract Syringic acid (SA) is a natural phenolic acid that possesses antioxidant properties. The current study aimed to assess the possible ameliorative effects of SA on oxidative stress in patients with acute myeloid leukemia (AML). Twenty-two healthy donors as well as 22 sex- and age-matched AML patients participated in the study. AML patients were at the time of diagnosis and before remission. The peripheral blood mononuclear cells (PBMCs) and plasma samples were obtained and divided into four groups. The groups include: 1) buffer (B), containing isotonic phosphate buffer saline (100 mM, pH 7.4, 1 hr); 2) OX, containing solution subjected to iron-mediated oxidation (2.7 µM, 1 hr); 3) SA, containing SA solution (10 µM, 1 h) as ROS quencher and 4) SA + OX in which samples were pretreated with 10 µM of SA for 1 h, and then exposed to OX solution (2.7 µM) for 1 h. The results indicated that SA caused a significant increase in the activity of glutathione peroxidase (GPX) in PBMCs. Of note, the treatment of PBMCs and plasma samples of AML patients with SA was able to normalize the altered levels of GPX, superoxide dismutase (SOD), and catalase (CAT). The antioxidant effect of SA was further confirmed by analyzing the total oxidant status, lipid peroxidation, and protein carbonylation in both plasma samples and PBMCs of AML patients. According to the results, it seems that SA has strong protective effects on oxidative stress by elevating the total antioxidant status (TAS) of PBMCs and plasma specimens from AML patients. Graphical Abstract
Abundances in the interstellar medium

SummaryRecent developments in the theory of element production and the chemical evolution of the galaxy are presented. Following this, observational data and their interpretation are given. A case by case analysis of results for D, He, Li and CNO isotope data in the disk and center of our galaxy is presented; previous results for element gradients are also summarized.The primordial abundances of D and He cannot be directly obtained from observations; corrections for stellar processing are discussed. From these data and the Li abundances, it appears that the abundance of the light elements is consistent with the standard big bang. In agreement with previous results, the range ofη, the baryon to photon ratio, is 5–8 10−10. If the amount of non-baryonic matter is small, these results indicate an open universe, in the standard big bang model.New data show a gradient in the (12C/13C) and (16O/18O) ratios with galactocentric distance, DGC. The presence of a gradient in the (14N/15N) ratio is less clear and there is no measurable gradient in the (32S/34S) ratio. In the interstellar medium near the sun, the carbon isotope ratio is −20 percent lower than the solar system ratio. This indicates that there has been only a moderate amount of enrichment of the nearby interstellar medium since the formation of the solar system. These results and previously determined galactic element gradients are interpreted in the framework of chemical evolution models. Delayed recycling of nucleosynthesis products is essential for the correct interpretation of the results. Comparisons of data with galactic evolution models are discussed.
An analysis of the vortex street generated in a viscous fluid

An analytic solution for the velocity field of a vortex street generated in a viscous fluid is developed. A method is presented for the determination of the true transverse spacing of vortices. Experimental geometry and velocity data, obtained by hot-wire techniques, are presented. The experimental results verified the validity of the analytic solution. The vortices of a real viscous vortex street were found to resemble very closely the exponential solution of the Navier-Stokes equations for an isolated axisymmetric rectilinear vortex. Three basic regions of vortex street behaviour were apparent at each Reynolds number investigated-a ‘formation region’ in which the vortex street is developed and large dissipation of vorticity occurs, a ‘stable region’ in which the vortices display a stable periodic laminar regularity, and an ‘unstable region’ in which the street disappears and turbulence develops. Geometry and velocities were determined.
Assessment of community perceptions and risk to common zoonotic diseases among communities living at the human-livestock-wildlife interface in Nakuru West, Kenya: A participatory epidemiology approach

Background Zoonoses account for most of the emerging and re-emerging infections in Kenya and in other low to medium-income countries across the world. The human-livestock-wildlife interface provides a nexus where transmission and spread of these zoonotic diseases could occur among communities farming in these areas. We sought to identify perceptions of the community living near the Lake Nakuru National Park in Kenya. Methods We used participatory epidemiology techniques (PE) involving Focus Group Discussion (FGD) among community members and Key Informant Interviews (KII) with the health, veterinary, and administration officers in July 2020. We used listing, pairwise matching, and proportional piling techniques during the FGDs in the randomly selected villages in the study area from a list of villages provided by the area government officers. Kruskal–Wallis test was used to compare the median scores between the zoonotic diseases, source of information, and response to disease occurrence. Medians with a z-score greater than 1.96 at 95% Confidence Level were considered to be significant. Content analysis was used to rank qualitative variables. Results We conducted seven FGDs and four KIIs. A total of 89 participants took part in the FGDs with their ages ranging from 26 to 85 years. Common zoonotic diseases identified by participants included anthrax, rabies, and brucellosis. Anthrax was considered to have the greatest impact by the participants (median = 4, z>1.96), while 4/7 (57%) of the FGDs identified consumption of uninspected meat as a way that people can get infected with zoonotic diseases. Community Health Volunteers (Median = 28, z = 2.13) and the government veterinary officer (median = 7, z = 1.8) were the preferred sources of information during disease outbreaks. Conclusion The participants knew the zoonotic diseases common in the area and how the diseases can be acquired. We recommend increased involvement of the community in epidemio-surveillance of zoonotic diseases at the human-wildlife-livestock interface.
Migration of biocides from paperboard into food simulants and vegetables

Abstract The migration of the biocides: 2-methyl-2H-isothiazol-3-one (MIT), 1,2-benzisothiazol-3(2H)-one (BIT) and 2-phenoxyethanol (PHE) from spiked paperboard into the simulants Tenax®, water and acetic acid (3%) has been studied and compared with that into the vegetables: red cabbage, lettuce and cauliflower. The migration of the biocides into the vegetables is significant and it shows the trend BIT > PHE > MIT, at both 4 °C and room temperature (RT), whatever tested foodstuff and with the highest value corresponding to BIT into cauliflower at RT (71%). Differences up to one order of magnitude between the biocides migration into Tenax® (<4.3%) and that into the vegetables indicate that Tenax® is not a suitable food simulant to mimic the selected vegetables in terms of the migration of the studied biocides. Water has been shown to be the most appropriate food simulant in the cases under study.
Regional differences in health screening participation between before and during COVID-19 pandemic

Background Health screening is a preventive and cost-effective public health strategy for early detection of diseases. However, the COVID-19 pandemic has decreased health screening participation. The aim of this study was to examine regional differences in health screening participation between before and during COVID-19 pandemic and vulnerabilities of health screening participation in the regional context. Methods Administrative data from 229 districts consisting of 16 provinces in South Korea and health screening participation rate of each district collected in 2019 and 2020 were included in the study. Data were then analyzed via descriptive statistics and geographically weighted regression (GWR). Results This study revealed that health screening participation rates decreased in all districts during COVID-19. Regional vulnerabilities contributing to a further reduction in health screening participation rate included COVID-19 concerns, the population of those aged 65+ years and the disabled, lower education level, lower access to healthcare, and the prevalence of chronic disease. GWR analysis showed that different vulnerable factors had different degrees of influence on differences in health screening participation rate. Conclusions These findings could enhance our understanding of decreased health screening participation due to COVID-19 and suggest that regional vulnerabilities should be considered stringent public health strategies after COVID-19.
The timing versus resource problem in nonnative sentence processing: Evidence from a time-frequency analysis of anaphora resolution in successive wh-movement in native and nonnative speakers of French

Nonnative processing has been argued to reflect either reduced processing capacity or delayed timing of structural analysis compared to the extraction of lexical/semantic information. The current study simultaneously investigates timing and resource allocation through a time-frequency analysis of the intrinsic neural activity during syntactic processing in native and English-speaking nonnative speakers of French. It involved structurally constrained anaphora resolution in bi-clausal wh-filler-gap dependencies such as Quelle décision à propos de lui est-ce que Paul a dit que Lydie avait rejetée sans hésitation? ‘Which decision about him did Paul say that Lydie rejected without hesitation? ’. We tested the hypothesis that nonnative speakers may allocate greater resources than native speakers to the computation of syntactic representations based on the grammatical specifications encoded in lexical entries, though both native and nonnative processing involves the immediate application of structural constraints. This distinct resource allocation is likely to arise in response to higher activation thresholds for nonnative knowledge acquired after the first language grammar has been fully acquired. To examine this bias in nonnative neurocognitive processing, we manipulated the wh-filler to contain either a lexically specified noun complement such as à propos de lui ‘about him’ or a non-lexcially specified noun phrase modifier such as le concernant ‘concerning him’. We focused on processing at the intermediate gap site, that is, the point of information exchange between the matrix and the embedded clauses by adopting a measurement window corresponding to the bridge verb dit ‘said’ and subordinator que ‘that’ introducing the embedded clause. Our results showed that structural constraints on anaphora produced event-related spectral perturbations at 13-14Hz early into the presentation of the bridge verb across groups. An interaction of structural constraints on anaphora with group was found at 18-19Hz early into the presentation of the bridge verb. In this interaction, the nonnative-speaker activity at 18-19Hz echoed the concurrent general patterns at 13-14Hz, whereas the native-speaker activity revealed distinct power at 18-19Hz and at 13-14Hz. There was no evidence of delay of structural constraints on intermediate gaps with respect to lexical access to the bridge verb and subordinator. However, nonnative speakers’ allocation of power in cell assembly synchronizations of fillers and gaps at the intermediate gap site reflected the grammatical specifications lexically encoded in the fillers.
Propagation of radio waves past a coast line with a gradual change of surface impedance

The amplitude and phase of a radio ground wave are calculated for an oblique crossing of a flat-lying coast line. The surface impedance is allowed to change in a continuous and gradual manner in the vicinity of the coast line. The earlier results for an abrupt boundary are recovered as the width of the transition zone is reduced to zero. In general, it is found that the presence of the transition region will not produce a significant modification of the transmitted field. On the other hand, the reflected waves and the behavior of the field near the coast line are profoundly influenced by the width of the transition. In particular, certain singular behavior of the field associated with an abrupt boundary is virtually eliminated when the transition zone has a finite width.
Correction of late adolescent skeletal Class III using the Alt-RAMEC protocol and skeletal anchorage

This case report describes skeletal anchorage-supported maxillary protraction performed with the Alternate Rapid Maxillary Expansion and Constriction (Alt-RAMEC) protocol over a treatment duration of 14 months in a 16-year-old female patient who was in the late growth-development period. Miniplates were applied to the patient's aperture piriformis area to apply force from the protraction appliance. After 9 weeks of following the Alt-RAMEC protocol, miniplates were used to transfer a unilateral 500-g protraction force to a Petit-type face mask. A significant improvement was observed in the soft tissue profile in measurements made both cephalometrically and in three dimensional photographs. Subsequently, the second phase of fixed orthodontic treatment was started and the treatment was completed with the retention phase. Following treatment completion, occlusion, smile esthetics, and soft tissue profile improved significantly in response to orthopedic and orthodontic treatment.
Reduced Number of Thymoma CTLA4-Positive Cells Is Associated With a Higher Probability of Developing Myasthenia Gravis

Background and Objectives Myasthenia gravis (MG) is an autoimmune disease associated with comorbid thymoma in 10%–15% of cases. Cytotoxic T lymphocyte–associated antigen 4 (CTLA4) expressed by T cells downregulates T-cell–mediated immune response. Polymorphisms in the CTLA4 gene have been associated with the development of MG. In this context, we aimed to determine whether CTLA4 expression in the thymoma differs between patients with and without MG and whether CTLA4 gene polymorphisms are associated with these differences. Methods This is a retrospective study of all patients, with and without MG, surgically treated at our institution for thymoma between January 2010 and December 2020. Ten samples were obtained from normal thymuses as controls. The number of CTLA4-positive cells in paraffin-embedded thymoma samples was determined by immunohistochemistry. The presence of follicular-center and regulatory T-cell lymphocytes was determined by immunohistochemistry (B-cell lymphoma [BCL]-6 expression) and double immunofluorescence–based staining of CD4-FOXP3, respectively. We evaluated the association between thymic expression of CTLA4 and the development of MG. We also determined the association between CTLA4 expression and various clinical and prognostic characteristics of MG. We sequenced the CTLA4 gene and evaluated possible associations between CTLA4 polymorphisms and thymic CTLA4 expression. Finally, we assessed the potential association between these polymorphisms and the risk of MG. Results Forty-one patients with thymoma were included. Of them, 23 had comorbid MG (56.1%). On average, patients with MG had fewer CTLA4-positive cells in the thymoma than non-MG patients: 69.3 cells/mm2 (95% CIs: 39.6–99.1) vs 674.4 (276.0–1,024.0) cells/mm2; p = 0.001 and vs controls (200.74 [57.9–343.6] cells/mm2; p = 0.02). No between-group differences (MG vs non-MG) were observed in the number of cells positive for BCL6 or CD4-FOXP3. CTLA4 expression was not associated with differences in MG outcome or treatment refractoriness. Two polymorphisms were detected in the CTLA4 gene, rs231770 (n = 30 patients) and rs231775 (n = 17). MG was present in a similar proportion of patients for all genotypes. However, a nonsignificant trend toward a lower CTLA4-positive cell count was observed among carriers of the rs231775 polymorphism vs noncarriers: 77.9 cells/mm2 (95% CI: −51.5 to 207.5) vs 343.3 cells/mm2 (95% CI: 126.2–560.4). Discussion Reduced CTLA4 expression in thymoma may predispose to a higher risk of developing MG.
Brain-derived Neurotrophic Factor and High Sensitive C-reactive Protein in Bipolar Depression and Unipolar Depression: The Practical Usage as a Discriminatory Tool

Objective Brain-derived neurotrophic factor (BDNF) and high sensitive C-reactive protein (hs-CRP) have been reported to play roles in depression and bipolar disorder (BD). However, the probable discriminatory properties of these biologic markers are less investigated. We aimed to assess the serum BDNF and hs-CRP levels among Iranian patients with major depressive disorder (MDD) and BD during a depressive episode and investigate the optimum cut-off point for differential diagnosis of BD and MDD. Methods We recruited 30 patients with MDD, 30 with BD in depressive mood and 30 healthy comparators. Blood sample was taken from each participant to measure BDNF and hs-CRP levels. We also used receiver operating characteristic (ROC) curve analysis to find an optimal cut-off point for differentiating MDD from BD according to pre-defined variables. Results The mean age of total study population was 37.3 ± 5.0 years (males 49%). BDNF was significantly lower in patients with BD, followed by MDD subjects and healthy controls 541.0 ± 601.0 pg/ml vs. 809.5 ± 433.3 pg/ml vs. 1,482.1 ± 519.8, respectively, p < 0.001). The area under curve of ROC curve analysis for BD versus MDD was 0.704 (95% confidence interval 0.564−0.844, p = 0.007). We also found that the BDNF cut-off value of 504 could appropriately distinguished BD from MDD (sensitivity 73%, specificity 70%). No significant association were identified in terms of hs-CRP levels. Conclusion Patients suffering from BD had lowest BDNF levels compared to MDD or healthy adults and this biomarker could play a practical role differentiating MDD from BD. Several studies are required confirming our outcomes.
Relation of ATPase6 Mutations and Telomere Length in Schizophrenia Patients

Objective Schizophrenia is a serious mental disorder. Mutations in mitochondrial genes can change energy metabolism. Telomere is a tandem sequence at the end of chromosomes. Shorter telomere length has been shown in schizophrenia. The aim of this study was to determine the relationship between ATPase6 gene mutations and telomere length in schizophrenia patients. Methods Blood samples of 34 patients and 34 healthy controls were used. In this study conventional PCR, Sanger sequencing technic and real-time PCR were utilized. Results Five different mutations (A8860G, A8836, G8697A, C8676T, and A8701G) in the ATPase6 gene were identified in schizophrenia patients. The most seen mutation was A8860G (94%). Telomere length analysis indicated the relation of ATPase6 gene mutations and telomere length variations (p = 0.001). Patients carrying the A8860G mutation had shorter telomere lengths than patients carrying other mutations. Comparing telomere length between schizophrenia patients and healthy controls revealed that the mean telomere length of schizophrenia patients was shorter than healthy controls (p = 0.006). The demographic analysis demonstrated a significant relationship between marital status and telomere length (p = 0.011). Besides that, the duration of the illness is another factor that impacts telomere length (p = 0.044). There is no significant relation between telomere length and other clinical and demographic characteristics including education status, age, gender, etc. Conclusion In conclusion, telomere length and ATPase6 gene mutations have a significant relation. Studies with larger patient populations and investigation of other mitochondrial gene mutations will make the clearer link between telomere length and mitochondrial mutations.