Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of oleic acid on vegetative growth of the aphid-pathogenic fungus Erynia neoaphidis

The aphid-pathogenic fungus Erynia neophidis grew on a semi-defined medium containing 16 g·1−1 glucose, 3 g·1−1 yeast extract and 5 g·1− mycological peptone only when the medium was supplemented with low concentrations of certain fatty acids. Of these, oleic acid fulfilled the growth requirement at a concentration of 0.02% (v/v), but higher concentrations were toxic, causing complete loss of viability of cultures at a concentration of 0.2% (v/v) in liquid medium and at 4% (v/v) on solid medium. The reduced viability of the fungus in liquid culture compared to that on equivalent solid medium, and at low inoculum density compared to high inoculum density in liquid medium, is explicable in terms of this toxicity.
SIRT3 promotes auditory function in young adult FVB/nJ mice but is dispensable for hearing recovery after noise exposure

Noise-induced hearing loss (NIHL) affects millions of people worldwide and presents a large social and personal burden. Pharmacological activation of SIRT3, a regulator of the mitochondrial oxidative stress response, has a protective effect on hearing thresholds after traumatic noise damage in mice. In contrast, the role of endogenously activated SIRT3 in hearing recovery has not been established. Here we tested the hypothesis that SIRT3 is required in mice for recovery of auditory thresholds after a noise exposure that confers a temporary threshold shift (TTS). SIRT3-specific immunoreactivity is present in outer hair cells, around the post-synaptic regions of inner hair cells, and faintly within inner hair cells. Prior to noise exposure, homozygous Sirt3-KO mice have slightly but significantly higher thresholds than their wild-type littermates measured by the auditory brainstem response (ABR), but not by distortion product otoacoustic emissions (DPOAE). Moreover, homozygous Sirt3-KO mice display a significant reduction in the progression of their peak 1 amplitude at higher frequencies prior to noise exposure. After exposure to a single sub-traumatic noise dose that does not permanently reduce cochlear function, compromise cell survival, or damage synaptic structures in wild-type mice, there was no difference in hearing function between the two genotypes, measured by ABR and DPOAE. The numbers of hair cells and auditory synapses were similar in both genotypes before and after noise exposure. These loss-of-function studies complement previously published gain-of-function studies and help refine our understanding of SIRT3’s role in cochlear homeostasis under different damage paradigms. They suggest that SIRT3 may promote spiral ganglion neuron function. They imply that cellular mechanisms of homeostasis, in addition to the mitochondrial oxidative stress response, act to restore hearing after TTS. Finally, we present a novel application of a biomedical statistical analysis for identifying changes between peak 1 amplitude progressions in ABR waveforms after damage.
Dietary patterns and risk of mild cognitive impairment among Chinese elderly: A cross-sectional study

Objective To investigate the relationship between food patterns and mild cognitive impairment (MCI) among Chinese elderly to provide evidence for risk prevention and control of MCI among elderly population. Methods Between February 2017 to October 2018, a stratified multistage cluster sampling method was used to select participants from 760 communities of six districts in Xi’an, China, for 49-item food frequency questionnaire survey. A total of 2311 participants aged 60 to 88 years were included in the study with 444 (19.2%) participants of MCI among Chinese community-dwelling elderly adults. Food patterns associated with risk of dementia were assessed by using a reduced rank regression (RRR) analysis, and the multivariate linear regression was used to test trends of risk factors across scores for the food pattern. Results Four dietary patterns were extracted which explained 88.65% of the total variation in food intakes. Furthermore, the food pattern 1 (FP1) accounted for 60.25% of the total variation of all responsible variables and as a target dietary pattern in the study, which was related with high intake of legumes, vegetables, fruits, milk and dairy products, nuts and a low intake of noodles and cereals (p<0.05). Multivariate linear regression analysis showed that participants with a high score for FP1 had higher direction, memory and language function and FP1 can improve the ability of cognitive function (p<0.05). Conclusion The FP1 of Chinese dietary patterns was significantly correlated with higher cognitive function which can reduce the risk of MCI among Chinese elderly.
Importance of diurnal refugia to a hare-wallaby reintroduction in Western Australia

In an effort to learn more about the potential for reintroduction of hare-wallabies to sites in Australia, 34 captive-bred hare-wallabies were released onto Peron Peninsula within the Shark Bay World Heritage Property in 2001 as part of an experimental reintroduction program. One objective of this experiment was to characterise their behaviour and daytime refugia to identify suitable habitat for future releases. The mala (Lagorchestes hirsutus) and merrnine (Lagostrophus fasciatus) were fitted with radio-transmitters and tracked daily. Merrnine were more faithful to a previously occupied shelter than mala. Mala maintained a solitary daytime habit at all times. Within the study area, mala preferentially sought low-lying vegetation primarily comprising the species Lamarchea hakeifolia, which provided dense cover up to 1 m in height, under which they constructed scrapes. L. hakeifolia was preferred as shelter vegetation instead of Triodia (spinifex) hummocks, despite Triodia hummock habitat being preferred by mala in central Australia. Merrnine occupied taller vegetation with an open understorey to 1.5 m, although the extremity of the understorey remained dense at this height. Individual merrnine sometimes sheltered with conspecifics of the opposite sex. Since both species utilised floristically and structurally variable vegetation, we suggest that they have the ability to cope with vegetation that has been altered by changes in fire regimes and introduced herbivores. This is particularly important for future reintroduction exercises as the results suggest that vegetation characteristics required to support these species, particularly mala, may be variable rather than limited to perceived necessary habitat types in central Australia or on islands. These results should allow future reintroduction projects to consider a wider range of release-site options during their planning phase.
Fast AHRS Filter for Accelerometer, Magnetometer, and Gyroscope Combination with Separated Sensor Corrections

A new predictor–corrector filter for attitude and heading reference systems (AHRS) using data from an orthogonal sensor combination of three accelerometers, three magnetometers and three gyroscopes is proposed. The filter uses the predictor—corrector structure, with prediction based on gyroscopes and independent correction steps for acceleration and magnetic field sensors. We propose two variants of the filter: (i) one using mathematical operations of special orthogonal group SO(3), that are accurate for nonlinear operations, for highest possible accuracy, and (ii) one using linearization of nonlinear operations for fast evaluation. Both approaches are quaternion-based filter realizations without redundant steps. The filters are compared to state of the art methods in this field on data recorded using low-cost microelectromechanical systems (MEMS) sensors with ground truth measured by the VICON optical system. Both filters achieved better accuracy than conventional methods at lower computational cost. The recorded data with ground truth reference and the source codes of both filters are publicly available.
The K/T Trial

s with Programs 26:333. Johnson, K. , and D. Nichols. 1994. Fossil plants and the Cretaceous Tertiary boundary in the northern great plains-the best terrestrial argument for an abrupt catastrophe. Geological Society of America, Abstracts with Programs 26:395. Keller, G. 1994. Global biotic effects of the KT boundary event: mass extinction restricted to low latitudes? Lunar and Planetary Institute Contribution 825:57-58. Markwick, P. J. 1994. Crocodilian distribution and diversity across the Cretaceous-Tertiary boundary. Implications for climatically induced extinction. Geological Society of America, Abstracts with Programs 26:395.s with Programs 26:395. Marshall, C. R. 1994. Using the ammonite fossil record to predict the position of the KT boundary Ir anomaly on Seymour This content downloaded from 207.46. 13.57 on Fri, 09 Sep 2016 04:07:18 UTC All use subject to http://about.jstor. org/terms ^4M ATTT, CW T TWs RPCC)RD 247 Island, Antarctica. Geological Society of America, Abstracts with Programs 26:394. Raup, D. M. , and D. Jablonski. 1994. Lack of selective extinction among end-Cretaceous bivalves. Geological Society of America, Abstracts with Programs 26:394. Schultz, P. 1994. Impact angle effects of global lethality. Geological Society of America, Abstracts with Programs 26:333. Sharpton, V. L. , L. E. Marin, and B. C. Schuraytz. 1994. The Chicxulub multiring impact basin: evaluation of geophysical data, well logs, and drill core samples. Lunary and Planetary Institute Contribution 825:108-1 10. Sigurdsson, H. , S. D'Hondt, and S. Carey. 1994. Impact extinction mechanisms: geochemistry of the target material. Geological Society of America, Abstracts with Programs 26:333. Zinsmeister, W. J., and R. M. Feldmann. 1994. Antarctica, the forgotten stepchild: a view of the KT extinction from the high southern latitudes. Lunar and Planetary Institute Contribution
Correlation between chlorophyllide esterification, Shibata shift and regeneration of protochlorophyllide650 in flash‐irradiated etiolated barley leaves

The pigments of etiolated leaves of barley (Hordeum vulgare L.) were analysed during dark periods after flash illumination, and the results were compared with in vivo spectroscopy of the leaves. Pretreatment of the leaves with kinetin slightly stimulated and pretreatment with NaF and anaerobiosis inhibited the esterification of chlorophyllide a (Chlide) at 10–40 min after the flash, whereas the rapid esterification within 30 s after the flash remained unchanged. Irrespective of pretreatment, the amount of esterified pigment was, at any time, identical with the amount of pigment that had shifted its absorption from 684 to 672 nm (Shibata shift). Cycloheximide (CHI) had only a small inhibitory effect on esterification, but drastically inhibited the hydrogenation of geranylgeraniol to phytol, bound to Chlide. The regeneration of long-wavelength protochlorophyllide a (Pchlide650) was stimulated by kinetin and inhibited by CHI and NaF. During the rapid phase (0–30 s after the flash), the esterification was faster than the regeneration of Pchlide650, and this, in turn, was faster than the formation of photoactive Pchlide. The kinetics changed after pretreatment with 5-aminolaevulinic acid: regeneration of Pchlide650 was the fastest reaction and the Shibata shift preceded the esterification of Chlide. The results are discussed as pigment exchange reactions at NADPH:protochlorophyllide oxidoreductase (POR; EC 1.6.99.1).
Foraging theory and partial consumption in a tardigrade–nematode system

We investigated foraging behavior of a carnivorous eutardigrade, Macrobiotus richtersi, living in soil or fresh water sediments, where the distribution of nematode prey is heterogeneous and where, consequently, the value of information about prey availability should be high. We directly observed diet choice in various mixtures of 2 size classes of nematodes Acrobeloides nanus, A1 (small prey) and A2 (large prey), differing in profitability (biomass divided by handling time) but not in digestive quality. At various prey densities of A2, we measured how much of each prey item was consumed as a function of search time. Additionally, we derived cumulative biomass uptake rates per single A2 prey from 154 complete feeding acts, and we used the marginal value theorem (MVT) to predict optimal residence time and prey exploitation as a function of environmental quality and search time. Macrobiotus richtersi did not preferentially select the more profitable size class A2 but increased its biomass uptake rate by modifying the amount consumed per prey item (partial consumption): when encounter rates were high and there were more high-quality prey, the tardigrade abandoned food more quickly and consumed less biomass per captured prey. We conclude that 1) hungry tardigrades under food-rich or food-limited conditions maximize biomass gain according to MVT and 2) tardigrades differentiate at least 2 prey situations, high supply (at high encounter rates) and low supply (at moderate and low prey densities). 3) Partial consumption, performed under food-rich conditions or by a satiated predator, leads to a reduction of prey numbers up to 3 times as much as under food-poor conditions. Copyright 2009, Oxford University Press.
The Association between Perceived Social Hardship and Future Orientation among Hong Kong Young People: The Mediation Role of Belief in a Just World

A positive future orientation (FO) is associated with a range of positive outcomes. It is a crucial resilience factor that assists individuals to navigate developmental difficulties during the transition to young adulthood and during periods of social adversity. Exposure to negative social context threatens young people’s FO. The social demonstrations and the outbreak of coronavirus disease in Hong Kong over the past year have caused considerable hardship to the local society. Under such circumstance, young people in Hong Kong may develop a negative FO. Scant research has directly examined the relationship between perceived social hardship and FO as well as the underlying mechanism among Hong Kong young people. In this study, we tested the idea that young people’s perceived social hardship would be negatively related to FO via belief in a just world, a well-known foundation for individuals to think, feel, and plan their future. Participants were 554 students recruited from eight universities in Hong Kong. They filled in self-report questionnaires online. Results of structural equation modeling supported our hypothesis. These findings shed light on how to nurture Hong Kong young people to develop a positive mindset during periods of social hardship.
The effect of placental laterality at 20–24 gestational weeks on uterine artery doppler indices, fetal growth and preeclampsia

Abstract Background This study aimed (i) to assess the potential effect of placental location on uterine artery (UtA) pulsatility index (PI) and offspring birthweight (BW), and (ii) to examine the potential association of unilaterally increased UtA PI with preeclampsia (PE) or low BW. Materials and methods This was an asynchronous cohort study of singleton pregnancies between 20+0 and 23+6 gestational weeks resulting in live birth, for whom the placental site (posterior, anterior, fundal, previa, right lateral, or left lateral) and bilateral UtA PI measurements were recorded. The effect of placental location on mean BW and UtA mean PI z-scores was assessed using t-test or ANOVA and post-hoc tests, as appropriate. The UtA PI measurements were then grouped into three categories (normal mean PI; unilaterally increased PI with normal mean; increased mean PI) and we calculated the odds ratios (ORs) of unilaterally increased or increased mean PI vs. normal mean PI for PE, BW <10th centile and BW <5th centile. The independent association of placental location, UtA PI category (normal mean, unilateral increase with normal mean, increased mean PI) and UtA PI z-score with PE, BW <10th centile and BW <5th centile was then assessed using logistic regression. Results The analysis included 5506 pregnancies. A lateral placenta was associated with higher mean PI z-score (p = .0001) and lower BW (p = .003) than non-lateral placenta. Compared with normal mean UtA PI, a unilaterally increased PI with a normal mean was associated with increased risk for PE (OR 4.3, 95%CI 1.9–9.7), BW <10th centile (OR 1.7, 95%CI 1.3–2.4) and BW <5th centile (OR 1.8, 95%CI 1.1–2.9). Similarly, increased mean UtA PI was also associated with increased risk for PE, BW <10th and BW <5th centile (OR 9.1, 95%CI 4.8–17.3; OR 4.4, 95%CI 3.5–5.7; OR 7.0, 95%CI 5.1–9.6, respectively). When assessing the independent association of placental location and UtA PI with PE and low BW, only mean UtA PI remains a significant predictor. Conclusions A lateral placenta is associated with a higher mean UtA PI and lower BW. Unilaterally increased UtA PI still carries a greater risk of PE and low BW than bilaterally normal PI, however this effect appears to be eventually mediated through mean UtA PI z-score, which is relatively increased in these cases.
Influence of population isolation on genetic variation and demography in Seychelles warblers: a field experiment

Between 1959 and 1968 the entire world population of Seychelles warblers (Acrocephalus sechellensis) comprised only 26–29 individuals entirely confined to Cousin Island (26 ha). Through conservation actions the island population has reached a carrying capacity of ca 320 birds since 1982. The warbler population has significantly lower levels of genetic variation, as determined by multilocus DNA fingerprinting, compared with its mainland relative, the Australian warbler (Acrocephalus australis) and other outbred natural bird populations (mean band sharing coefficients are 0.50, 0.22 and 0.21, respectively), and has a very low annual reproductive rate of 0.28 yearlings per breeding pair. Therefore some degree of inbreeding may have occurred in this population.
NF-κB Activation Accounts for the Cytoprotective Effects of PERK Activation on Oligodendrocytes during EAE

Previous studies demonstrate that activation of pancreatic ER kinase (PERK) protects oligodendrocytes against inflammation in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Interestingly, data indicate that the cytoprotective effects of PERK activation on oligodendrocytes during EAE are not mediated by activating transcription factor 4 (ATF4) but are accompanied by activation of nuclear factor κB (NF-κB). NF-κB plays a critical role in MS and EAE; however, the effects of NF-κB activation on oligodendrocytes in these diseases remain elusive. Herein, we generated a mouse model that allow for activation of NF-κB specifically in oligodendrocytes and found that enhanced NF-κB activation in oligodendrocytes had a minimal effect on their viability and function under normal conditions (both male and female mice). Interestingly, we found that enhanced NF-κB activation in oligodendrocytes attenuated EAE disease severity and ameliorated EAE-induced oligodendrocyte loss, demyelination, and axon degeneration, without affecting inflammation (female mice). Moreover, we showed that the detrimental effects of PERK inactivation in oligodendrocytes in EAE were accompanied by impaired NF-κB activation in oligodendrocytes, and were completely rescued by enhanced NF-κB activation in oligodendrocytes (female mice). These findings suggest that NF-κB activation accounts for the cytoprotective effects of PERK activation on oligodendrocytes in MS and EAE. SIGNIFICANCE STATEMENT Nuclear factor κB (NF-κB) is activated in oligodendrocytes in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE); however, the role of NF-κB activation in oligodendrocytes in MS and EAE remains elusive. Herein, we generated a mouse model that allows for activation of NF-κB selectively in oligodendrocytes and demonstrated that NF-κB activation prevented oligodendrocyte death and myelin damage in the EAE model. We further demonstrated that NF-κB activation contributed to the protective effects of pancreatic ER kinase (PERK) activation on oligodendrocytes in the EAE model. As such, this work will facilitate the development of new treatments that enhance oligodendrocyte survival in MS patients by targeting the PERK-NF-κB pathway.
Effect of continuous positive airway pressure on maximal exercise capacity in patients with obstructive sleep apnea: a systematic review and meta-analysis.

STUDY OBJECTIVES Exercise capacity is impaired in obstructive sleep apnea (OSA). There are conflicting reports on the effect of CPAP on maximal exercise capacity. The objective of this review was to determine if there is a change in exercise capacity and anaerobic threshold following continuous positive airway pressure (CPAP) treatment in OSA patients. METHODS We conducted a systematic review and meta-analyses to summarize the changes in peak rate of oxygen uptake (V̇O₂peak) or maximum rate of oxygen uptake (V̇O₂max) and anaerobic threshold (AT) during cardiopulmonary exercise testing following CPAP intervention in patients with OSA. A systematic literature review was conducted to identify published literature on markers of V̇O₂ peak, V̇O₂ max and AT pre versus post CPAP using a web-based literature search of PubMed/MEDLINE, Embase, CINAHL and Cochrane review (CENTRAL) databases. Two independent reviewers screened the articles for data extraction and analysis. RESULTS The total search of all the databases returned 470 relevant citations. Following application of eligibility criteria, six studies were included in the final meta-analysis for V̇O₂ peak, two studies for V̇O₂ max, and five studies for AT. The meta-analysis showed a mean net difference in V̇O₂ peak between pre and post CPAP of 2.69 mL·kg-1·min-1, p=0.02, favoring the treatment with CPAP. There was no difference in V̇O₂ max or AT with CPAP treatment (mean net difference 0.66 mL·kg-1·min-1 (0.78) and -144.98 mL·min-1 (p=0.20) respectively). CONCLUSIONS There is a paucity of high-quality studies investigating the effect of CPAP on exercise capacity. Our meta-analysis shows that V̇O₂ peak increases following CPAP treatment in patients with OSA, but we did not observe any change in V̇O₂ max or AT, Our findings should be considered preliminary and we recommend further randomized controlled trials to confirm our findings and to clarify the V̇O₂ adaptations with CPAP therapy. CLINICAL TRIAL REGISTRATION The study is registered on PROSPERO [ID number 138158] (www.crd.york.ac.uk).
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

Advances in gene therapy have been foreshadowing its potential for the treatment of a vast range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and successful outcome are highly dependent on the development of the ideal gene delivery system. On that matter, silica-based vectors have diverted some attention from viral and other types of non-viral vectors due to their increased safety, easily modifiable structure and surface, high stability, and cost-effectiveness. The versatility of silane chemistry and the combination of silica with other materials, such as polymers, lipids, or inorganic particles, has resulted in the development of carriers with great loading capacities, ability to effectively protect and bind genetic material, targeted delivery, and stimuli-responsive release of cargos. Promising results have been obtained both in vitro and in vivo using these nanosystems as multifunctional platforms in different potential therapeutic areas, such as cancer or brain therapies, sometimes combined with imaging functions. Herein, the current advances in silica-based systems designed for gene therapy are reviewed, including their main properties, fabrication methods, surface modifications, and potential therapeutic applications.