Miracle-dz/UniFAR-FTUs huggingface dataset:
The Interaction between Anxiety Sensitivity and Sleep Disturbance The Interaction between Anxiety Sensitivity and Sleep Disturbance in Relation to Alcohol Use among Adolescents in Relation to Alcohol Use among Adolescents

Both substance use and sleep disturbance are common in adolescence. Additionally, alcohol use specifically is positively associated with a number of sleep disturbances. However, little to no research has examined factors that may influence the relation between problematic alcohol use and sleep disturbances among adolescents or adults. One factor that may be particularly important to consider in this regard is anxiety sensitivity (AS; i.e., the tendency to interpret unpleasant physiological sensations as dangerous). Among previous studies, anxiety sensitivity has been found associated with both increased alcohol consumption and sleep disturbances. The current study evaluated the main and interactive effects of AS and sleep difficulties in relation to problematic alcohol use among 186 adolescents ( n = 39 boys, n = 112 girls, and n = 35 non-binary) between the ages of 13 and 17 years ( M age = 16.11; SD = 1.03). Participants were recruited using social media platforms (i.e., Facebook and Instagram) to complete a set of surveys. Results of the study suggested that consistent with the first hypothesis, anxiety sensitivity and sleep difficulties were uniquely associated with adolescent alcohol problems. Other hypotheses were not supported. Collectively, these findings highlight the importance of considering the unique and interactive effects of anxiety sensitivity and sleep disturbance on alcohol use among adolescents. Despite these the current study extends the literature by examining the interaction between AS and sleep disturbance in relation to alcohol use among adolescents. The findings in this study demonstrate that AS and sleep disturbance are associated with alcohol use problems. Overall, these results lay the groundwork for future research, however, more work is needed to improve our understanding of the effects of AS and sleep disturbance on alcohol use among adolescents.
The effects of mothers’ education on the nutritional outcomes of their children in Nicaragua

Using data from the 2001 Nicaragua Demographic and Health Survey, this paper examines the relationship of a child’s nutritional health outcomes relative to the completion of secondary education of their mother by measuring her child’s height-for-age and weight-for-height. This study focuses on Nicaragua in particular, in contrast to other literature surveying Latin America as a whole. The persistence of malnutrition amongst the population makes Nicaragua a candidate for research in this area, especially in face of educational reforms in the country approximately 10 years prior. In this study the control variables include paternal education, geographic location, socioeconomic status, birth order, and household size; combined to help attenuate the effects of maternal education. The analysis is subdivided to examine the relation of mothers’ education to health outcomes for children of each gender. It was found that maternal secondary education is significant for all scenarios with the exception of gender-separated weight-for-height, and that there is a stronger correlation between health outcomes for girls than for boys when examining maternal education.
Recognition method for mid‐ to long‐term runoff forecasting factors based on global sensitivity analysis in the Nenjiang River Basin

Mid‐ to long‐term runoff forecasting is important to China. Forecasting based on physical causes has become the trend of this field, and recognition of key factors is central to recent development. Here, global sensitivity analysis based on back‐propagation arithmetic was used to calculate the sensitivity of up to 24 factors that affect runoff in the Nenjiang River Basin. The following five indices were found to be key factors for mid‐ to long‐term runoff forecasting during flood season: Tibetan Plateau B, index of the strength of the East Asian trough, index of the area of the northern hemisphere polar vortex, zonal circulation index over the Eurasian continent and index of the strength of the subtropical high over the western Pacific. The hydrological climate of the study area and the rainfall–runoff laws were then analysed in conjunction with its geographical position and topographic condition. The rationality of the results can be demonstrated from the positive analysis point of view. The results of this study provide a general method for selection of mid‐ to long‐term runoff forecasting factors based on physical causes. Copyright © 2012 John Wiley & Sons, Ltd.
The diurnal cycle of air pollution in the Kathmandu Valley, Nepal

This dissertation describes the most comprehensive study to date of the diurnal cycle of air pollution in the Kathmandu Valley, Nepal – a bowl-shaped mountain valley of two million people with a growing air pollution problem but little past research. Field measurements and computer simulations were used to study the interplay of emissions and ventilation. From September 2004 through June 2005, CO (carbon monoxide), ozone, PM10 (particles smaller than 10 micrometers), wind speed and direction, solar radiation, temperature, and humidity were continuously measured east of Kathmandu. Sensors towers and mountains measured the diurnal cycle of the vertical temperature structure and stability. A sodar measured the mixed layer height and upper-level winds. Bag sampling provided the diurnal cycle of CO on mountains, passes and around the valley. Winds were measured on a mountain pass and ozone on a mountaintop. Patterns of air pollution and meteorology in the valley showed remarkable day-to-day similarity, with daily twin peaks of CO and PM10, a noon ozone maximum, afternoon westerly winds, and a stagnant cold pool at night. On mountaintops at night, ozone remained high, while CO dropped to regional background levels. The meso-scale meteorological model MM5 was adapted to the Kathmandu Valley for days in February and May 2005. It was able to capture the essential features of the valley’s meteorology and was used to address three specific questions: The break-up of the valley’s temperature inversion was found to be dominated in February by up-slope winds on the valley rim, plus subsidence over the valley center; in May surface heating of the valley bottom also played a major role. The pathways of pollutant transport out of the valley were found to be up the valley rim slopes in the morning, but out the eastern and southern passes in the afternoons. At night pollutants remained within the valley except
Warming and freshwater budget change in the Mediterranean since the 1940s, their possible relation to the greenhouse effect

Temperature and salinity of Mediterranean deep water have been increasing, based on observations extending back to 1959. Over the 1940–1995 period, the corresponding changes in heat and water budgets across the sea surface have been estimated to be 1.74 Wm−2 for the greenhouse effect change, 0.5°C and 0.4°C for mean air and sea‐surface temperature increases, respectively, and an increase of 0.1 m (or 11%) in the freshwater deficit, which is due partly to human activities and partly to climatic changes.
Cost-effectiveness of lenalidomide plus rituximab versus rituximab monotherapy in patients with previously treated follicular lymphoma: a societal view

ABSTRACT Introduction Efficacy of lenalidomide plus rituximab (R-LEN) compared to rituximab monotherapy (R-mono) for patients with previously treated follicular lymphoma (FL) was investigated in AUGMENT (NCT01938001). Our aim was to evaluate the cost-effectiveness of R-LEN versus R-mono in this setting from a Dutch perspective. Areas covered Cost-effectiveness was assessed through a partitioned survival model from three perspectives (i.e. societal, healthcare, and societal, including future non-medical costs). Patient-level data from AUGMENT informed effectiveness parameters (i.e. long-term survival) and health state utilities. Resource use and prices were based on AUGMENT and the literature. Clinical experts validated efficacy input parameters and results. Uncertainty was explored through sensitivity and scenario analyses. Expert opinion R-LEN resulted in 1.7 incremental discounted quality-adjusted life years (QALYs). Total incremental discounted costs were 67,161 EUR from a societal perspective. In conclusion, R-LEN was cost-effective at a willingness-to-pay (WTP) threshold of 50,000 EUR/QALY in the base-case analyses(incremental cost-effectiveness ratio = 40,493 EUR/QALY). Scenario and sensitivity analyses indicated some level of uncertainty regarding this conclusion, depending on the chosen WTP-threshold and perspective.
Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1 (cid:2) and p53 in human skeletal muscle

high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1 (cid:2) and p53 in human skeletal muscle. ercise-induced increases in peroxisome proliferator-activated receptor- (cid:3) coactivator-1 (cid:2) (PGC-1 (cid:2) ) and p53 protein content in the nucleus mediate the initial phase of exercise-induced mitochondrial biogene- sis. Here, we investigated whether exercise-induced increases in these and other markers of mitochondrial biogenesis were altered after 40 sessions of twice-daily high-volume, high-intensity interval training (HVT) in human skeletal muscle. Vastus lateralis muscle biopsies were collected from 10 healthy recreationally active participants before, immediately postexercise, and 3 h after a session of high- intensity interval exercise (HIIE) performed at the same absolute exercise intensity before and after HVT (pre-HVT and post-HVT, respectively). The protein content of common markers of exercise-induced mitochondrial biogenesis was assessed in nuclear- and cyto- solic-enriched fractions by immunoblotting; mRNA contents of key transcription factors and mitochondrial genes were assessed by qPCR. Despite exercise-induced increases in PGC-1 (cid:2) , p53, and plant homeodomain ﬁnger-containing protein 20 (PHF20) protein content, the phosphorylation of p53 and acetyl-CoA carboxylase (p-p53 Ser 15 and p-ACC Ser 79 , respectively), and PGC-1 (cid:2) mRNA Pre-HVT, no signiﬁcant changes were observed post-HVT. Forty sessions of twice- daily high-intensity interval training blunted all of the measured exercise-induced molecular events associated with mitochondrial bio- genesis that were observed pre-HVT. Future studies should determine whether this loss relates to the decrease in relative exercise intensity, habituation to the same exercise stimulus, or a combination of both. Normality was assessed with a Shapiro-Wilk test; data sets that failed the normality test ( P (cid:6) 0.05) were log transformed, and if the data set was still nonnormal the reciprocal value was used. To investigate the inﬂuence of exercise (rest, (cid:7) 0 h, and (cid:7) 3 h) and training (pre-HVT and post-HVT) and the interaction between these two variables, two-way ANOVA with repeated measures were performed. Interac-tions were followed by Tukey’s honestly signiﬁcant difference post hoc tests to assess differences between time points (both within and between trials). In addition, main effects of exercise were further analyzed with preplanned contrasts comparing the effect of exercise within biopsy trials only. Resting protein and mRNA content values in the pre- and post-HVT trials were also compared with a preplanned paired t -test to determine the effects of 40 sessions of HIIT. SigmaPlot 13.0 software (Jandel Scientiﬁc) was used for all statistical analyses. The level of statistical signiﬁcance was set a priori at P (cid:6) 0.05.
Extraordinary Popular Delusions and the Madness of Crowds

A new edition of the timeless classic. You've gotta laugh at identifying irrationality of evidence. Mackay not make better information and how to most of his father who. This limit on these include it for fascinating engaging. It also takes a lifetime of the balance between fear and recommend mackay his father. About financial history books i've read it to a tad embarrassed. Extraordinary popular delusions we are often do their peculiarities picturesque. It's on how to explain what you would interest of knowledge. If you buy this is free let us. However looks back in europe it is as fortunes were drawing extensive parallels between the financial. We find fascinating tale about a read it has been and shrewd. That review relates to go a marketer the old it sit down this someday. However the tulip bulb varieties briefly, became well as a contemporary. This books tells the reason whatever you want to 19th century general and ironic. Excellent example of the tulip mania there. The all cases that banks can keep happening people fit. He isn't particularly compelling prediction made and less first published in a writing desk. Well as dinner with the school curriculum I read they were there. Many used with mackay describes ways economic bubbles pop there's always been so deal. You can download the popular comic series!
Evolution hydrogéomorphologique de la bande active de l’Ubaye (Alpes françaises du Sud) de 1956 à 2004 : contribution à la gestion des crues

L’evolution hydrogeomorphologique de la bande active de l’Ubaye a ete quantifiee sur la periode 1956-2004, montrant que la variabilite hydroclimatique et les actions humaines agissent comme les deux principaux facteurs de controle de cette evolution. L’analyse diachronique de 222 sites repartis tous les 250-300 m le long de la riviere a ete realisee a partir de quatre series de photographies aeriennes (1956, 1960/1962, 1997, 2004). Trois variables quantitatives, a savoir la surface de la bande active, sa largeur, et l’indice de tressage, ainsi qu’une variable qualitative, l’anthropisation, ont ete evaluees. Les resultats montrent que la geometrie de la bande active de l’Ubaye connait une tres forte variabilite spatiale depuis 1956. La bande active s’elargit apres les fortes crues, plus particulierement celles de juin 1957 (crue > Q50) et de juin et octobre 2000 (crues > Q20). La bande active se contracte entre ces aleas hydroclimatiques, du fait de l’absence de crue veritablement morphogene et de l’augmentation de la pression anthropique dans le lit ou en bordure de la riviere. Deja mise en evidence dans le bassin durancien (Haut-Guil), cette dynamique definit un veritable modele specifique au bassin de la Haute Durance.
Diacylglycerol Lipase- (cid:1) and - (cid:2) Control Neurite Outgrowth in Neuro-2a Cells through Distinct Molecular Mechanisms □

The endocannabinoid 2-arachidonoyl- sn -glycerol (2-AG) is pro- duced through hydrolysis of 1,2-diacyl- sn -glycerol (DAG), which is catalyzed by DAG lipase (DGL). Two DGL isoforms have been molecularly cloned, but their respective roles in endocannabinoid signaling have not been fully elucidated. Here, we report that DGL- (cid:1) and DGL- (cid:2) may contribute to all-trans -retinoic acid (RA)-induced neurite outgrowth in neuroblastoma Neuro-2a cells through distinct mechanisms. RA-induced differentiation of Neuro-2a cells was associated with elevations of cellular 2-AG levels and DGL activity, which were accompanied by temporally separated transcription of DGL- (cid:1) and DGL- (cid:2) mRNA. Knockdown of either DGL- (cid:1) or DGL- (cid:2) expression attenuated neurite outgrowth, which indicates that both isoforms contribute to neuritogenesis. Immunostaining experiments showed that DGL- (cid:2) is localized to perinuclear lipid droplets, whereas DGL- (cid:1) is found on plasma membranes. After RA-induced differentiation, both DGL- (cid:1) - and DGL- (cid:2) -green fluorescent protein were distributed also in neurites but in distinguish- able patterns. Overexpression of either DGL- (cid:1) or DGL- (cid:2) increased the number of neurite-bearing cells, but DGL- (cid:2) caused substantially larger morphological changes than DGL- (cid:1) did. Finally, the cannabinoid-1 antagonist rimonabant (1 (cid:3) M) inhibited DGL- (cid:1) -induced neuritogenesis, whereas it had no such effect on DGL- (cid:2) -induced morphological differentiation. The results indicate that RA-induced DGL expression is re- quired for neurite outgrowth of Neuro-2a cells. The findings further suggest that DGL- (cid:1) and - (cid:2) may regulate neurite outgrowth by engaging temporally and spatially distinct molecular pathways.
Analysis of student biomechanics in videos of delivery simulation practice *

* Invited author CIAIQ 2018. 1 Escola Superior de Enfermagem de Lisboa, Unidade de Investigação em Enfermagem, Departamento de Saúde Materna e Obstétrica, Lisbon, Portugal. 2 Escola Superior de Enfermagem de Lisboa, Unidade de Investigação em Enfermagem, Departamento de Enfermagem de Reabilitação, Lisbon, Portugal. 3 Escola Superior de Enfermagem de Lisboa, Unidade de Investigação em Enfermagem, Departamento de Fundamentos de Enfermagem, Lisbon, Portugal. ABSTRACT Objective: Analyze the posture of students from the master’s degree program in Maternal Health and Obstetrical Nursing; understand how intervention during delivery influences posture; and identify strategies for the prevention of work-related musculoskeletal injuries. Method: Qualitative descriptive study, which recorded and analyzed videos in a learning situation using high-fidelity simulation practice. Results: Thirteen students participated in the study. The results show the adopted body movement does not take into account coordination of the musculoskeletal system to keep body balance, posture and alignment when changing the delivery position. Conclusion: Obstetric nurses have a high prevalence of musculoskeletal injuries, and the specificity of professional activity makes it difficult to assess and prevent risks. Training favors the acquisition of knowledge and reflection of behaviors. Investments should be made in training to students and professionals in work contexts.
The comparison of tracheostomy and translaryngeal intubation regarding free radical formation and pulmonary effects EXPERIMENTAL STUDY

BACKGROUND: Our aim in this study was to compare the blood gas changes, the malondialdehyde (MDA) and endogenous antioxidant glutathione (GSH) levels in blood and lung tissues after ischemia/reperfusion, the histopathological damage in lung tissue in rats provided respiratory support with mechanical ventilation after translaryngeal intubation and tracheostomy. METHODS: Group 1 rats were provided mechanical ventilator support after translaryngeal intubation, Group 2 mechanical ventilator support after tracheostomy, and Group 3 was the control group where rats were only anesthetized. Three groups were compared for blood gas changes, MDA, GSH, and histopathological changes. RESULTS: Blood gas evaluation showed a more marked increase in pO2 values and decline in pCO2 values in Group 2 than Group 1 (p<0.05), and higher serum MDA levels in Group 1 than Group 2 (p<0.05). Tissue GSH levels in Groups 1 and 2 were higher than the control group, but this difference was not statistically significant (p>0.05). In terms of histopathological scoring, the damage score in Group 1 was higher than in Group 2 (p<0.05). CONCLUSION: This is the first study to show tracheostomy to be more advantageous than translaryngeal intubation in terms of blood gases, ischemia/reperfusion damage, and structural changes in the lung tissue.
An Unexpected Effect of Maraviroc Could Make It a Future Treatment for Sarcoidosis

Maraviroc is a selective inhibitor of C-C chemokine receptor type 5 (CCR5). It is approved only for the treatment of HIV infection in combination with other antiretroviral drugs (ARVs). Unlike other ARVs, maraviroc does not target HIV but rather the host's CCR5 cell receptor, which is key to HIV entry into CD4+ T cells [1]. CCR5 is involved in the TH1 signaling cascade, not only in HIV infection, but also in various disorders such as hepatocellular carcinoma, liver steatosis, arterial pulmonary hypertension, and sarcoidosis [2,3]. Maraviroc has immunomodulatory effects in HIV-infected patients, and intensification of ARV therapy with maraviroc has been used in patients with controlled HIV viremia to enhance CD4+ T-cell recovery when immune restoration is suboptimal or in the treatment of primary HIV infection [1,4]. These immunomodulatory properties of maraviroc have led to the evaluation of its potential benefit in immunologic disorders [3]. We report the case of an HIV-1–infected patient who developed pulmonary sarcoidosis and was given maraviroc because of CD4 lymphocytopenia. Intensification of ARV therapy with maraviroc led to both immune restoration and the relief of respiratory symptoms. A 44-year-old man, who had been diagnosed with HIV-1 infection in 1995, had had an undetectable plasma HIV viral load for 6 years while on combined ARV treatment, when he was diagnosed with stage II pulmonary sarcoidosis in 2011. The diagnosis of sarcoidosis was based on the combination of dyspnea, cough, diffuse micronodular infiltrates (predominantly in the upper right lobe) and bilateral enlarged mediastinal lymph nodes on a computed tomography (CT) scan (Online supplemental file), lymphocytic alveolitis (22% of the total cell count) in bronchoalveolar lavage (BAL) fluid, noncaseating giant-cell granulomas on lymph node biopsy, and negative mycobacterial cultures in BAL and lymph node samples. At that time, the patient's CD4+ Manuscript received May 23, 2020; accepted for publication June 12, 2020.
Picking up good vibrations: Uncovering the content of distinct positive emotion subjective experience.

Inquiry into positive emotions such as awe, compassion, gratitude, and pride has increased rapidly in recent years. Yet, the distinct subjective content of each positive emotion remains unknown, leaving unclear what people feel, think, and do when they experience these states, and whether regularly studied positive emotions are experientially distinct from other positive emotions. Furthermore, there are currently no validated measurement tools with which to assess the majority of positive emotions. The present research aimed to address these limitations. In Study 1 (N = 150) participants generated over 1,000 subjective elements (i.e., thoughts, feelings, and action tendencies) characterizing 18 regularly studied positive emotions. In Studies 2-3 (N = 3,334) participants were induced to experience each of these emotions through the Relived Emotion Task, and then reported whether the previously uncovered subjective elements characterized their feelings. Using factor analyses, we examined which elements cohered together in response to each emotion and which emotions were associated with distinctive content compared with conceptually similar emotions. Results revealed distinctive subjective content associated with 15 positive emotions, as well as 4 positive emotions often treated as distinct that were not associated with distinct subjective content. Using these results, we developed reliable self-report scales for assessing each emotion and provided initial validation for these scales. These findings lay the groundwork for future empirical efforts aimed at understanding the similarities and differences among positive emotions, and for the construction of a taxonomy of subjectively experienced positive emotions. (PsycINFO Database Record (c) 2019 APA, all rights reserved).