Miracle-dz/UniFAR-FTUs huggingface dataset:
Dental Anxiety and Oral-Health-Related Quality of Life among Rural Community-Dwelling Older Adults

Abstract Aim: This study aimed to investigate the association between dental anxiety (DA) and oral-health-related quality of life (OHRQoL) among rural community-dwelling older adults. Methods: A cross-sectional descriptive study was conducted among 390 rural community-dwelling older adults attending outpatient clinics of the Damanhur National Medical Institute during the year 2021. Three instruments were used: a demographic and clinical data structured interview schedule, Modified Dental Anxiety Scale (MDAS), and the Oral Health Impact Profile (OHIP-5) questionnaire. All statistical analyses were considered significant at a p-value of ≤0.001. Results: The main results showed that the prevalence of DA among participants was 90.5%, and 66.9% of the studied elderly population were either extremely (phobic) or very anxious. Moreover, a significant association was found between older adults’ DA and their OHRQoL (p ˂ 0.001). Conclusions: It was concluded that DA represents a common problem among rural community-dwelling older adults and is a predictor for poor OHRQoL. Raising community awareness about the importance of oral health and implementing measures to avoid DA through specialized community campaigns is recommended, particularly in rural areas.
Acute and Chronic Captopril, but Not Prazosin or Nifedipine, Normalize Alterations in Adrenergic Intracellular Ca 2 (cid:1) Handling Observed in the Mesenteric Arterial Tree of Spontaneously Hypertensive Rats

The effect of hypertension and acute (36-h) or chronic (from age 6 to 16 weeks) antihypertensive treatment with prazosin (2 mg kg (cid:2) 1 per day), nifedipine (50 mg kg (cid:2) 1 per day), or captopril (50 mg kg (cid:2) 1 per day) on Ca 2 (cid:1) mobilization due to (cid:1) 1 -adrenoceptor activation was analyzed in functional studies using arterial rings [four conductance/distributing vessels: aorta, main mesenteric, iliac, and tail arteries and two resistance vessels; first and second small mesenteric artery branches obtained from spontaneously hypertensive rats (SHR, 6 and 16 weeks old) and age-matched Wistar Kyoto rats (WKY)]. Maximal response to noradrenaline in the presence of extracellular Ca 2 (cid:1) is not af-fected by hypertension or by the antihypertensive treatment. The extracellular Ca 2 (cid:1) -independent contractile responses increased with age in iliac, tail, and small mesenteric mmol/l NaHCO 3 , and 11 mmol/l glucose. In Ca 2 (cid:1) -free solution, CaCl 2 was omitted and 0.1 mM EDTA was added. The following drugs were obtained from Sigma-Aldrich (St. Louis, MO): ( (cid:2) )-noradrenaline, Cremophor EL, ionomycin, prazosin, nifedipine, and captopril. Fura-2 acetoxymethyl ester (1 (cid:3) M solution in dimethyl sulfoxide) was from Calbiochem (San Diego, CA). Other reagents were of analytical grade. All compounds were dissolved initially in distilled water except ionomycin, which was dissolved in absolute ethanol. Prazosin and captopril were dissolved in drinking water for the treatment of the animals. Nifedipine was prepared in absolute ethanol and diluted in drinking water until a final concentration of 0.02% ethanol.
DDDT_A_253232 1693..1704

Brooke Benner* Logan Good * Dionisia Quiroga 2 Thomas E Schultz Mahmoud Kassem 2 William E Carson Mathew A Cherian 2 Sagar Sardesai 2 Robert Wesolowski 1Department of Surgery, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA; 2Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA; 3Department of Pharmacy, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
Challenges in Implementing the WHO Hospital Readiness Checklist for the COVID-19 Pandemic in Indonesian Hospitals: A Qualitative Study

Purpose To assist hospitals in preparing for a surge of patients during the COVID-19 pandemic, the World Health Organization (WHO) published an assessment tool called the rapid hospital readiness checklist. This checklist has been used by numerous countries, including Indonesia. However, several technical issues were discovered, primarily as a result of the manual recording of the checklist on a spreadsheet. This study aimed to identify challenges related to the hospital readiness checklist that was implemented in Indonesia. Materials and Methods This qualitative study used focus group discussions to collect data. The study was conducted in East Java, Indonesia, in October 2021, with the participation of nine organizations from the provinces of East Java and Bali. Data were thematically analyzed, and the findings were presented in a narrative format. Results Hospital participants had experience in filling out a hospital readiness checklist every 3 months. Some challenges faced by the hospital was the need to manually enter data into the checklist, lack of coordination and communication, there were various perceptions in hospitals as there was no technical guide in completing the checklist, absence of feedback, and the data returning empty due to filling errors. Additionally, City X health office also identified challenges in monitoring and evaluating the hospital checklists. Conclusion This study, which included both hospitals and the health office, described the challenges encountered in the assessment of the hospital readiness checklist. Both hospitals and DHO experienced some challenges with the current system. The checklist has the potential to evolve into a public reporting to improve efficiency and faster decision-making.
Effects of spinning-wing decoys on flock behavior and hunting vulnerability of local and migrant mallards and other ducks in Minnesota

Waterfowl managers in Minnesota and other states are concerned that increased kill rates associated with the use of spinning-wing decoys (SWDs) may negatively affect local breeding populations of mallards (Anas platyrhynchos). I conducted 219 experimental hunts to evaluate hunting vulnerability of mallards to SWDs during the 2002 duck-hunting season in Minnesota. Following experimental hunts, I asked volunteer hunters to complete post-hunt questionnaires to document their hunting experience, and their use and opinions of SWDs. Finally, I used stable isotope methodology to determine natal origins of HY mallards killed during experimental hunts. I found that mallard flocks (≥1 duck) were 2.91 times more likely to respond (i.e., approached within 40 m of hunters) when SWDs were turned ‘ON’. Sizes of responding mallard flocks were 1.25 times larger, on average, when SWDs were turned ‘ON’ than ‘OFF’. Mallards killed/hr/hunter/hunt averaged 4.71 times higher (P < 0.05) when SWDs were turned ‘ON’ than ‘OFF’. More HY and AHY mallards were killed when SWDs were turned ‘ON’ than ‘OFF’; however, AHYs were relatively less likely than were HYs to be killed with SWDs turned ‘ON’. Based on my stable isotope analysis, more local and migrant HY mallards were killed by hunters when SWDs were turned ‘ON’ than ‘OFF’, but local HY mallards were not relatively more likely than were migrant HY mallards to be killed by hunters using SWDs in Minnesota. I found no evidence that SWDs reduced crippling nor allowed hunters to harvest relatively more drakes than hens. I estimated that if 46% and 79% of Minnesota hunters used SWDs in 2000 and 2002, respectively, Minnesota mallard harvest would increase by factors of 2. However, increasing use of SWDs may result in a partial re-distribution of annual mallard harvests if naïve ducks are harvested upon initial exposures to SWDs, and those ducks that survive migrations to wintering areas become habituated to SWDs, as suggested by my results. My study was confined to a
Validity of the Food Frequency Questionnaire—Estimated Intakes of Sodium, Potassium, and Sodium-to-Potassium Ratio for Screening at a Point of Absolute Intake among Middle-Aged and Older Japanese Adults

Using Food Frequency Questionnaires (FFQs) to compare dietary references for screening has been in high demand. However, FFQs have been widely used for ranking individuals in a population based on their dietary intake. We determined the validity of sodium (salt equivalent) intake, potassium intake, and sodium-to-potassium (Na/K) ratio obtained using the FFQ for identifying individuals who deviated from the dietary reference intakes (DRIs) measured using multiple 24-h urinary excretion measurements or 12-day weighed food records (WFR). This study included 235 middle-aged subjects. The correlation coefficients (CCs) between the FFQ and WFR estimates were mostly moderate (0.24–0.54); the CCs between the FFQ and 24-h urinary excretion measurements were low or moderate (0.26–0.38). Values of area under the receiver-operating curve (AUC) at the point of DRIs for salt equivalent or potassium were >0.7 with the WFR as the reference standard and 0.60–0.76 with the 24-h urinary excretion as the reference standard. Using both standard measures, the AUC for the Na/K ratio was <0.7. The accuracy of salt equivalent and potassium intake estimation using the FFQ to determine absolute intake point was comparable to that using WFR, allowing for quantified error, but not as good as that of 24-h urinary excretion.
Glyn W. (2012) Parallel distractor rejection as a binding mechanism in search. Frontiers in Psychology, 3 (278). ISSN 1664-1078

The relatively common experimental visual search task of ﬁnding a red X amongst red O’s and green X’s (conjunction search) presents the visual system with a binding problem. Illusory conjunctions (ICs) of features across objects must be avoided and only features present in the same object bound together. Correct binding into unique objects by the visual system may be promoted, and ICs minimized, by inhibiting the locations of distractors possessing non-target features (e.g., Treisman and Sato, 1990). Such parallel rejection of interfering distractors leaves the target as the only item competing for selection; thus solving the binding problem. In the present article we explore the theoretical and empirical basis of this process of active distractor inhibition in search. Speciﬁc experiments that provide strong evidence for a process of active distractor inhibition in search are highlighted. In the ﬁnal part of the article we consider how distractor inhibition, as deﬁned here, may be realized at a neurophysiological level (Treisman and Sato, 1990).
Effect of Postoperative Ocular Residual Astigmatism (ORA) on Treatment Outcome After Myopic Laser in situ Keratomileusis (LASIK)

Purpose To analyze the impact of postoperative ocular residual astigmatism (ORA) on refraction, visual acuity and subjective satisfaction after myopic laser-in-situ-keratomileusis (LASIK) by a comprehensive analysis, which includes clinically relevant data and patient-reported outcomes. Material and Methods To evaluate the influence of ORA, comparison groups were built following Archer et al. Myopic patients were subdivided by the fraction ORA/MRC (matched and not matched for MRC) (MRC = manifest refractive cylinder), ORA magnitude and CA magnitude in high ORA eyes (CA = corneal astigmatism). Refractive and visual data were analyzed via retrospective cross-sectional analysis for multiple parameters. The subjective satisfaction was analyzed retrospectively 3–4 years after having LASIK via patient reported outcome analysis. Results Refractive outcome: Only when grouped by ORA magnitude only, high ORA eyes resulted in approximately twice as cylinder magnitude compared to eyes with preoperative lower ORA. Furthermore, there appeared to be no statistically significant differences in any case. Visual outcome: There appeared to be no statistically significant differences for visual acuity parameters (safety index, efficacy index). Patient reported outcome: When grouped by the rate of ORA/MRC not matching for MRC, there were statistically significant differences in the subjective satisfaction (p = 0.006) and the postoperative side effects (p = 0.001, p = 0.01, p = 0.006), those differences appeared less strong when matched for MRC treated and result better for a higher ratio of ORA/MRC. Conclusion Patients with postoperatively high ORA report on higher satisfaction with treatment results than patients with postoperatively low ORA. This did not correlate with differences in the refractive nor visual outcome. As a matter of fact, there is a discrepancy between the objective analysis results and the subjective satisfaction of patients.
Adoption of innovative mobile payment technologies in Indonesia: The role of attitude

Financial service industries have experienced dynamic technological innovation. The research objective of this paper is to identify factors influencing the intentions of potential users to adopt the newly launched innovative mobile payment applications. This study proposes a theoretical framework based on the technology acceptance model (TAM). One hundred sixty-nine respondents were involved in this investigation, and the data were gathered using an online survey. The collected data were analyzed using the SEM technique. The findings reveal that users’ attitude has an essential role in mediating the impact of the benefit and trust on the intention to adopt a mobile payment technology. This study also shows different results from the previous studies regarding user perceptions of attitudes. The ease of use of innovative digital applications does not significantly affect attitudes.Furthermore, an attitude positively impacts users’ intention to adopt innovative mobile payment applications. Therefore, user attitudes have an essential role in communicating the impact of the benefits derived from the intention to adopt an innovative mobile payment application. This study proves that innovative digital application providers need to pay attention to strategies for promoting their services. It is also vital for the providers to include the trust component in their service.
Updated species checklist of fishes from Lake Dongting in Hunan Province, South China: Species diversity and conservation

﻿Abstract A lack of an updated checklist of freshwater fish species from Lake Dongting is a great hindrance to further biodiversity analysis. A seasonal survey of fishes in the lake was conducted from October 2017 to January 2019. Based on the data obtained during the field survey and coupled with known literature and the latest taxonomic development of relevant taxa, the species checklist of fishes from Lake Dongting was updated. A total of 130 species from 12 orders, 30 families and 76 genera has been documented, containing 126 native species and four alien species. Its fish fauna is dominated by the Xenocyprididae that has the highest number of included species (30), followed by the Gobionidae (25) and Acheilognathidae (11). This checklist comprises 20 species undergoing nomenclatural changes and 11 new records, eight of which are native and three exotic. It excludes 20 species, which have been reported in error in historical works, due to synonyms, erroneous records, taxonomic changes and unconfirmed records. Unsampled in this survey were 34 species that are ecologically specialised: migratory, rheophilic, predatory, shellfish-dependent or pelagic-egg-spawning. While some of these species eluded capture likely due to the paucity of population, others may have been extirpated in Lake Dongting perhaps owing to human perturbations, such as river damming across affluents or the Chang-Jiang mainstem, sand dredging, overfishing or water pollution. The updated checklist lays a sound foundation for biodiversity conservation of fishes in Lake Dongting.
Association of Dietary Vitamin K Intake With Cognition in the Elderly

Several previous studies discussed the association between vitamin K (VK) status and cognition. But the association between dietary VK consumption and cognitive performance in the elderly was not well understood. Therefore, we investigated the correlation between dietary VK intake and the cognition of the elderly. Our research used the data of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014. The dietary intake of VK was assessed by two 24-h dietary recalls. The cognitive function was measured in the survey of NHANES, including the Consortium to Establish a Registry for Alzheimer’s disease Word Learning subtest (CERAD W-L), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). Logistic regression and restricted cubic spline models were applied to assess the relationship between dietary VK intake and cognition. Compared with the lowest dietary VK intake group, the multivariate-adjusted odds ratio (OR) [95% confidence interval (95% CI)] of low CERAD W-L score for the highest intake group was 0.39 (0.26–0.60), the multivariate-adjusted OR (95% CI) of low AFT score was 0.59 (0.38–0.92), and the multivariate-adjusted OR (95% CI) of low DSST score was 0.44 (0.29–0.65), respectively. There was an L-shaped dose–response relationship between dietary VK intake and low CERAD W-L score. There was a linear dose–response relationship between dietary VK intake and low AFT score, and there was also a linear dose–response relationship for the low DSST score. In addition, we also found a negative association between VK from vegetables and the risk of low CERAD W-L scores. Dietary VK intake and VK intake from vegetables were inversely related to the risk of low cognitive performance of the elderly.
The interaction mechanism of nickel ions with L929 cells based on integrative analysis of proteomics and metabolomics data

Abstract The aim of this article was to study the toxicity mechanism of nickel ions (Ni2+) on L929 cells by combining proteomics and metabolomics. First, iTRAQ-based proteomics and LC/MS metabolomics analyses were used to determine the protein and metabolite expression profiles in L929 cells after treatment with 100 μM Ni2+ for 12, 24 and 48 h. A total of 177, 2191 and 2109 proteins and 40, 60 and 74 metabolites were found to be differentially expressed. Then, the metabolic pathways in which both differentially expressed proteins and metabolites were involved were identified, and three pathways with proteins and metabolites showing upstream and downstream relationships were affected at all three time points. Furthermore, the protein–metabolite–metabolic pathway network was constructed, and two important metabolic pathways involving 4 metabolites and 17 proteins were identified. Finally, the functions of the important screened metabolic pathways, metabolites and proteins were investigated and experimentally verified. Ni2+ mainly affected the expression of upstream proteins in the glutathione metabolic pathway and the arginine and proline metabolic pathway, which further regulated the synthesis of downstream metabolites, reduced the antioxidant capacity of cells, increased the level of superoxide anions and the ratio of GSSG to GSH, led to oxidative stress, affected energy metabolism and induced apoptosis.
Long-Term Donor Site Morbidity and Flap Perfusion Following Radial versus Ulnar Forearm Free Flap—A Randomized Controlled Prospective Clinical Trial

This clinical prospective randomized controlled study aimed to investigate the differences between Radial (RFFF) and Ulnar (UFFF) Forearm Free Flap in terms of success, performance, and donor site morbidity. Thirty patients with reconstruction of the head and neck region were included. For the first time, this study assessed flap-perfusion characteristics, donor-site-wound-healing dynamics and hand perfusion using hyperspectral imaging. Further, subjective (Likert-scale, DASH-score) and objective (grip/pinch-strength) parameters of donor site morbidity were analysed. Postoperative follow-up was performed until 6 months after index surgery. With 100% of patients, RFFF and UFFF were equally successful. Compared to surrounding reference, UFFF revealed significant lower tissue oxygenation saturation (StO2) than RFFF. Compared with UFFF, blood flow in both the thenar and hypothenar region were significantly reduced 6 months following RFFF transfer. After four weeks, 27% more patients demonstrated impaired wound healing following RFFF transfer. After 6 months, epithelial-surface continuity was restored in all patients of both groups. After 6 months, overall rates of both subjective and objective donor site morbidity were comparable between RFFF and UFFF. RFFF and UFFF both demonstrate similar success rates and HSI-perfusion dynamics following transfer. After 4 weeks, wound-healing disorder appeared significantly more often in RFFF than in UFFF; however, they became equal after 6 months. RFFF and UFFF can be considered as mutual alternatives.
AN INTEGRATED APPROACH FOR STRUCTURAL HEALTH MONITORING OF CONCRETE STRUCTURES BASED ON ELECTROMECHANICAL ADMITTANCE AND GUIDED WAVES

Summary. An integrated monitoring approach for near and far-field damage detection in concrete structures based on simultaneous use of electromechanical admittance and guided wave propagation is presented in this work. The proposed sensing system uses arrays of PZT patches bonded on the surfaces of concrete structures which are serving as multi-mode sensors/actuators. This innovative technique takes advantage of two PZT basic capabilities: a) to serve as near-field damage detection sensors using the high-frequency electromechanical (E/M) admittance monitoring technique and b) to serve as far-field damage detection sensors using guided wave propagation monitoring technique. In the guided wave propagation, one PZT patch acts as actuator and launches an elastic wave through the structure, which then can be measured by another PZT patch which in the same time serves as admittance sensor. The integration approach of both two methodologies is then straightforward because the same piezoelectric patch can be used for both methods. This integration approach is experimentally validated in this work by inspecting the sensing capabilities of custom-made “multi-mode” sensing system for damage detection of concrete structures.
Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens

Substance use induces long-lasting behavioral changes and drug craving. Increasing evidence suggests that epigenetic gene regulation contributes to the development and expression of these long-lasting behavioral alterations. Here we systematically review extensive evidence from rodent models of drug-induced changes in epigenetic regulation and epigenetic regulator proteins. We focus on histone acetylation and histone methylation in a brain region important for drug-related behaviors: the nucleus accumbens. We also discuss how experimentally altering these epigenetic regulators via systemically administered compounds or nucleus accumbens-specific manipulations demonstrate the importance of these proteins in the behavioral effects of drugs and suggest potential therapeutic value to treat people with substance use disorder. Finally, we discuss limitations and future directions for the field of epigenetic studies in the behavioral effects of addictive drugs and suggest how to use these insights to develop efficacious treatments.