Miracle-dz/UniFAR-FTUs huggingface dataset:
Early versus delayed antiretroviral therapy based on genotypic resistance test: Results from a large retrospective cohort study

Rapid start of antiretroviral therapy (ART) pending genotypic resistance test (GRT) has been recently proposed, but the effectiveness of this strategy is still debated. The rate of virological success (VS), defined as HIV‐RNA < 50 copies/ml, with and without GRT was compared in drug‐naïve individuals enrolled in the Italian ARCA cohort who started ART between 2015 and 2018. 521 individuals started ART: 397 without GRT (pre‐GRT group) and 124 following GRT (post‐GRT group). Overall, 398 (76%) were males and 30 (6%) were diagnosed with AIDS. In the pre‐GRT group, baseline CD4+ cell counts were lower (p < 0.001), and viral load was higher (p < 0.001) than in the post‐GRT group. The estimated probability of VS in pre‐GRT versus post‐GRT group was 72.54% (CI95: 67.78–76.60) versus 66.94% (CI95: 57.53–74.26) at Week 24 and 92.40% (CI95: 89.26–94.62) versus 92.92% (CI95: 86.35–96.33) at Week 48, respectively (p = 0.434). At Week 48, VS was less frequent among individuals with baseline CD4+ cell counts <200 versus >500 (90.33% vs. 97.33%), log viral load <5.00 versus >5.70 log10 cps/ml (97.17% vs 78.16%; p < 0.001), and those treated with protease inhibitors or non‐nucleoside reverse transcriptase inhibitors versus those treated with integrase strand transfer inhibitors (p < 0.001). The rate of VS does not seem to be affected by an early ART initiation pending GRT results, but it could be influenced by the composition of the ART regimen, as well as immuno‐virological parameters.
Psychosocial Interventions for Patients With Heart Failure and Their Impact on Depression, Anxiety, Quality of Life, Morbidity, and Mortality: A Systematic Review and Meta-Analysis

ABSTRACT Objective The purpose of this systematic review and meta-analysis was to evaluate the ability of psychosocial interventions to reduce depression and anxiety, improve quality of life, and reduce hospitalization and mortality rates in patients with heart failure. Methods Studies of psychosocial interventions published from 1970 to 2021 were identified through four databases (PubMed, Ovid MEDLINE, PsycINFO, Cochrane). Two authors independently conducted a focused analysis and reached a final consensus on the studies to include, followed by a quality check by a third author. A risk of bias assessment was conducted. Results Twenty-three studies were identified, but only 15 studies of mostly randomized controlled trials with a total of 1370 patients with heart failure were included in the meta-analysis. Interventions were either cognitive behavioral therapy (CBT) or stress management. The pooled intervention effect was in favor of the intervention for depression (combined difference in standardized mean change [DSMC]: −0.41; 95% confidence interval [CI] = −0.66 to −0.17; p = .001) and anxiety (combined DSMC: −0.33; 95% CI = −0.51 to −0.15; p < .001) but was only a trend for quality of life (combined DSMC: 0.14; 95% CI = −0.00 to 0.29; p = .053). Evidence was limited that interventions produced lower rates of hospitalization (5 of 5 studies showing a beneficial effect) or death (1 of 5 with a beneficial effect). Conclusions CBT and stress management interventions significantly reduced depression and anxiety compared with control conditions. CBT significantly improved quality of life compared with controls, but stress management did not. Longer treatment duration seemed to be an important factor related to treatment success.
A Study on the Measurement of Human Mental Work-load in Ship Handling Using SNS Value

As the navigation environment has been changing recently, the methods of evaluation that accomplish to measure the operator's mental w orkload are desired. We propose the new measuring method using SNS values obtained through RRV procedure which can estimate the h uman mental workload moment to moment. In this paper, firstly we discuss the methods of data processing which enable to estimate the h uman mental workload in ship handling. And then, using proposed measurement methods, we estimated the human mental workload in tw o ship handling situations, namely fairway passing maneuvering and stopping maneuvering in short distance with keeping ship's heading. The obtained results are as follows ; (1) The useful signal can be selected by adapting the proposed filtering procedure. (2) The operator's mental workload under passing narrow fairway is corresponding to E-value which indicates difficulty of maneuvering concerning with the c haracteristic of ship and fairway conditions. (3) High level of human workload during altering course in fairway is shown in the before and t he after altering course rather than the time of changing course. (4) High level of human workload is shown in time with the occurrence of b ig difference between planed situation and realized one.
CEO Overconfidence and Capital Structure Decisions: Evidence from India

Executive Summary Capital structure decisions are vital for firms. Existing theories on capital structure partially explain the difference in capital structure decisions of identical firms. Researchers have integrated psychology with finance in recent years to explain the difference in capital structure decisions better. To help practitioners and academicians understand the role of psychology in capital structure decisions, this article focuses on CEO overconfidence and its influence on equity versus debt financing, short-term versus long-term debt financing, and level of debt financing concerning tax shields. Indian CEOs are unique in their leadership style, values and beliefs. Overconfidence among CEOs of S&P BSE 200 firms is measured using the press coverage of CEOs, and this proxy depicts how the press portrays CEOs. An extensive search on CEOs in relevant search engines helped measure overconfidence among CEOs. The results from regression models document that overconfident CEOs prefer debt over equity and short-term debt over long-term debt. In addition, overconfident CEOs are found to not avail the full benefits of tax shield and follow a conservative debt policy. The presence of bias of overconfidence among CEOs distorts optimal decision-making and deviates capital structure decisions from trade-off theory and pecking order theory of capital structure. The evidence on external versus internal financing helps explain the biased preference of overconfident CEOs for debt and short-term financing. The biased beliefs lead CEOs to form high expectations of cash flows. Overconfidence among CEOs is found to significantly influence capital structure decisions. The robustness of the results corroborates existing findings and documents the influence of behavioural biases on corporate decision-making.
KeV-neutron capture cross-section measurement of 197Au with a Cr-filtered neutron beam at the ANNRI beamline of MLF/J-PARC

ABSTRACT Cr-filtered keV-neutron experiments were performed in the Accurate Neutron-Nucleus Reaction Measurement Instrument (ANNRI) beamline in the Materials and Life Science (MLF) facility of the Japan Proton Accelerator Research Complex (J-PARC) to measure the neutron capture cross-section of 197Au. The energy range of the neutron filtering system at ANNRI was extended through the use of 15 cm of nat Cr as filter material to tailor quasi-monochromatic neutron peaks with averaged neutron energies of 133.4 and 45.0 keV. The performance of the nat Cr filter assembly was evaluated by means of experimental capture and transmission analyses, together with the use of Monte-Carlo simulations. The present 197Au neutron capture cross-section results provide agreement within uncertainties with the JENDL-4.0 evaluated library and the IAEA standard data library further demonstrating the capabilities of the neutron filtering system at ANNRI.
Cross-Cutting exposure, perceived realism, and online political engagement in the age of algorithms

ABSTRACT Considering the implications of cross-cutting exposure for democratic deliberation in the age of algorithms, this study proposes a conceptual model that delineates the roles of perceived realism and approval of algorithmic curation in the relationship between cross-cutting exposure and online political engagement. Secondary data obtained from the 2018 national survey conducted by the Taiwan Institute for Governance and Communication Research were utilized to test the relationships. The results indicated a negative association between cross-cutting exposure and online political engagement. The significant mediation model further showed that exposure to cross-cutting perspectives on social media was negatively associated with online political engagement by way of decreased perceived realism. That association was conditioned by the level of approval of algorithmic curation, which weakened the negative mediating role of perceived realism as it increased. Implications of those results and directions for future research are discussed.
Accepting Human-like Avatars in Social and Professional Roles

Humans report perceptions of unease or eeriness as humanoid/android robots and digital avatars approach human-like physical resemblance, a phenomenon alluded by the Uncanny Valley theory. This study extends the discussions on interactions and acceptance of digital avatars with findings from three experiments. In the first, perceptive evaluation of actors in clips from computer-generated animation and a live-action version of the same movie was examined. In the second experiment, we considered short clips with highly realistic digital avatars to measure recognition ability, the extent of eeriness, and specific physical features identified as unreal. The fixation area and pupil size variation recorded using an eye tracker were analyzed to infer attention to the body, face, and emotional response, respectively. Building on these findings, the third experiment looked at acceptance in roles requiring human skill, empathy, and cognitive ability. The results show that based on perceptions from physical attributes, the eeriness scores diverge from the uncanny valley theory as human-likeness increases. The realistic CGI and mocap technology could have helped cross the valley. Visual attention inferred from gaze behavior was similar for live-action and CGI. At the same time, we observe pupil size changes reflecting emotions like eeriness when the avatars either talked or smiled. Proficiency and acceptance scores were lower for roles requiring complex social cognition processes, such as friends and judicial decision-making. Interestingly, real-life stereotypes of gender roles were transferred to digital avatars too. The findings suggest an ambiguity in accepting human-like avatars in social and professional interactions, emphasizing the need for a multi-dimensional approach when applying the uncanny valley theory. A detailed and contextual examination is imperative as technological advancements have placed humans closer to co-existing with digital or physical android/humanoid robots.
MobiliSense cohort study protocol: do air pollution and noise exposure related to transport behaviour have short-term and longer-term health effects in Paris, France?

Introduction MobiliSense explores effects of air pollution and noise related to personal transport habits on respiratory and cardiovascular health. Its objectives are to quantify the contribution of personal transport/mobility to air pollution and noise exposures of individuals; to compare exposures in different transport modes; and to investigate whether total and transport-related personal exposures are associated with short-term and longer-term changes in respiratory and cardiovascular health. Methods and analysis MobiliSense uses sensors of location, behaviour, environmental nuisances and health in 290 census-sampled participants followed-up after 1/2 years with an identical sensor-based strategy. It addresses knowledge gaps by: (1) assessing transport behaviour over 6 days with GPS receivers and GPS-based mobility surveys; (2) considering personal exposures to both air pollution and noise and improving their characterisation (inhaled doses, noise frequency components, etc); (3) measuring respiratory and cardiovascular outcomes (smartphone-assessed respiratory symptoms, lung function with spirometry, resting blood pressure, ambulatory brachial/central blood pressure, arterial stiffness and heart rate variability) and (4) investigating short-term and longer-term (over 1–2 years) effects of transport. Ethics and dissemination The sampling and data collection protocol was approved by the National Council for Statistical Information, the French Data Protection Authority and the Ethical Committee of Inserm. Our final aim is to determine, for communicating with policy-makers, how scenarios of changes in personal transport behaviour affect individual exposure and health.
An adverse-pressure-gradient turbulent boundary layer with nearly constant $\beta \simeq 1.4$ up to $Re_{\theta } \simeq 8700$

Abstract In this study, a new well-resolved large-eddy simulation of an incompressible near-equilibrium adverse-pressure-gradient (APG) turbulent boundary layer (TBL) over a flat plate is presented. In this simulation, we have established a near-equilibrium APG over a wide Reynolds-number range. In this so-called region of interest, the Rotta–Clauser pressure-gradient parameter $\beta$ exhibits an approximately constant value of around 1.4, and the Reynolds number based on momentum thickness reaches ${\textit {Re}}_{\theta }=8700$. To the best of the authors’ knowledge, this is to date the highest ${\textit {Re}}_{\theta }$ achieved for a near-equilibrium APG TBL under an approximately constant moderate APG. We evaluated the self-similarity of the outer region using two scalings, namely the Zagarola–Smits and an alternative scaling based on edge velocity and displacement thickness. Our results reveal that outer-layer similarity is achieved, and the viscous scaling collapses the near-wall region of the mean flow in agreement with classical theory. Spectral analysis reveals that the APG displaces some small-scale energy from the near-wall to the outer region, an effect observed for all the components of the Reynolds-stress tensor, which becomes more evident at higher Reynolds numbers. In general, the effects of the APG are more noticeable at lower Reynolds numbers. For instance, the outer peak of turbulent-kinetic-energy (TKE) production is less prominent at higher $Re$. Although the scale separation increases with ${\textit {Re}}$ in zero-pressure-gradient TBLs, this effect becomes accentuated by the APG. Despite the reduction of the outer TKE production at higher Reynolds numbers, the mechanisms of energisation of large scales are still present.
Saying “no” in emails in Mandarin Chinese and Australian English

Abstract The present study examined the differences between Mandarin Chinese and Australian English in email refusals. An email production questionnaire (EPQ) and retrospective verbal reports (RVR) were used to collect data. Results showed that while both groups preferred directness to indirectness at the utterance level, Chinese participants used indirectness significantly more frequently than Australian participants in refusals of requests. In addition, Chinese refusals were more indirect than Australian refusals at the discourse level. Chinese participants chose significantly more supportive moves than Australian participants and tended to put multiple supportive moves before the direct head act in refusals of either invitations or requests. The two groups also differed considerably in the content of refusal strategies. Moreover, both the EPQ and RVR data showed that Chinese were more sensitive to social status than Australians. The findings of this study were broadly consistent with studies on refusals in oral communication despite some differences.
Pengaruh Kinerja Keuangan Terhadap Nilai Perusahaan Dengan Pengungkapan Corporate Social Responsibility dan Good Corporate Governance Sebagai Variabel Pemoderasi

Penelitian ini bertujuan untuk menganalisis pengaruh kinerja keuangan terhadap nilai perusahaan dengan pengungkapan Corporate Social Responsibility dan Good Corporate Governance sebagai variabel pemoderasi. Variabel yang digunakan ROA, CSR, dan kepemilikan manajerial. Nilai perusahaan dalam penelitian ini diproksi dengan nilai Tobins Q. Penelitian ini menggunakan data sekunder yaitu 15 perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia dalam kurun waktu 2009-2013. Teknik penentuan sampel menggunakan metode purposive sampling. Data diuji menggunakan analisis regresi berganda dan uji hipotesis. Hasil penelitian dengan analisis regresi linier menunjukkan bahwa ROA berpengaruh signifikan terhadap nilai perusahaan (t hitung = -3,828 ; sig = 0,000). Sedangkan analisis variabel moderating dengan pengungkapan CSR menunjukkan bahwa pengungkapan CSR tidak mampu memoderasi hubungan antara ROA terhadap nilai perusahaan (t hitung = -0,872 ; sig = 0,386). Kepemilikan manajerial juga bukan merupakan variabel moderating yang mampu memoderasi hubungan antara ROA terhadap nilai perusahaan (t hitung = 0,464 ; sig = 0,644). Selanjutnya secara simultan variabel ROA, interaksi antara ROA dengan CSR, dan interaksi antara ROA dengan Kepemilikan Manajerial berpengaruh signifikan terhadap nilai perusahaan (f hitung = 5,399 ; sig = 0,000).
The pre-Bötzinger complex is necessary for the expression of post-inspiration

The mammalian three-phase respiratory motor pattern of inspiration, post-inspiration and expiration is expressed in spinal and cranial motor nerve activities. This pattern is generated by a hierarchical brainstem-wide pre-motor network. However, the local rhythmogenic circuit of the pre-Bötzinger complex (pre-BötC) was established as the ‘noeud vitale’ necessary and sufficient to initiate inspiration. In present study, we tested the effect of unilateral and bilateral inactivation of the pre-BötC (microinjection of the GABAA receptor agonist isoguvacine 10 mM, 50 nl) on respiratory motor activities in an in situ perfused brainstem preparation of rat. As expected, bilateral inactivation of the pre-BötC triggered cessation of phrenic (PNA), hypoglossal (HNA) and vagal (VNA) nerve activities for 15-20 min. Partial recovery from bilateral isoguvacine injection was characterized by erratic activity in all recorded motor nerves reminiscent to patterns observed after disturbed excitatory-inhibitory balance within the local pre-BötC circuit. Surprisingly, ipsilateral isoguvacine injections into the pre-BötC triggered transient (6-8 min) cessation of inspiratory and post-inspiratory VNA (p<0.001) and suppressed inspiratory HNA by -70 ± 15% (p<0.01), while inspiratory PNA burst frequency increased by 46 ± 30% (p<0.01). Taken together, these observations confirm the role of the pre-BötC as the ‘noeud vitale’ of the mammalian respiratory network in situ and highlight a significant role for the pre-BötC in the expression of vagal post-inspiratory and inspiratory activity.
Tuberculosis treatment failure associated with evolution of antibiotic resilience

Antibiotics are a cornerstone of medicine, placing bacterial pathogens under intense pressure to evolve new survival mechanisms. Analysis of 51,229 Mycobacterium tuberculosis (Mtb) clinical isolates identified an essential transcriptional regulator, Rv1830 (here named resR) as a frequent target of positive (adaptive) selection. resR mutants do not demonstrate canonical drug resistance or drug tolerance but instead have significantly faster recovery after drug treatment across all antibiotics and combinations tested, a phenotype which we term antibiotic resilience. ResR acts in a regulatory cascade with other growth-controlling transcriptional regulators WhiB2 and WhiA, which are also under positive selection in Mtb clinical isolates. Mutations of these genes are associated with treatment failure and the acquisition of canonical drug resistance.
High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD

Patients with chronic obstructive pulmonary disease (COPD) are still waiting for curative treatments. Considering its environmental cause, we hypothesized that COPD will be associated with altered epigenetic signaling in lung cells. We generated genome‐wide DNA methylation maps at single CpG resolution of primary human lung fibroblasts (HLFs) across COPD stages. We show that the epigenetic landscape is changed early in COPD, with DNA methylation changes occurring predominantly in regulatory regions. RNA sequencing of matched fibroblasts demonstrated dysregulation of genes involved in proliferation, DNA repair, and extracellular matrix organization. Data integration identified 110 candidate regulators of disease phenotypes that were linked to fibroblast repair processes using phenotypic screens. Our study provides high‐resolution multi‐omic maps of HLFs across COPD stages. We reveal novel transcriptomic and epigenetic signatures associated with COPD onset and progression and identify new candidate regulators involved in the pathogenesis of chronic lung diseases. The presence of various epigenetic factors among the candidates demonstrates that epigenetic regulation in COPD is an exciting research field that holds promise for novel therapeutic avenues for patients.
Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila

Modification by sialylated glycans can affect protein functions, underlying mechanisms that control animal development and physiology. Sialylation relies on a dedicated pathway involving evolutionarily conserved enzymes, including CMP-sialic acid synthetase (CSAS) and sialyltransferase (SiaT) that mediate the activation of sialic acid and its transfer onto glycan termini, respectively. In Drosophila, CSAS and DSiaT genes function in the nervous system, affecting neural transmission and excitability. We found that these genes function in different cells: the function of CSAS is restricted to glia, while DSiaT functions in neurons. This partition of the sialylation pathway allows for regulation of neural functions via a glia-mediated control of neural sialylation. The sialylation genes were shown to be required for tolerance to heat and oxidative stress and for maintenance of the normal level of voltage-gated sodium channels. Our results uncovered a unique bipartite sialylation pathway that mediates glia-neuron coupling and regulates neural excitability and stress tolerance. Graphical Abstract
Genotype by microbiome interactions have large effects on growth in Lotus japonicus

Biological interactions between plants and their root microbiomes are pivotal for plant growth. Even though the plant genotype [G], soil microbiome [C], and growth conditions (environment) [E] are core factors shaping the root microbiome, their relationships remain unclear. We disentangled the effects of G, C, E, and their interactions on the Lotus root microbiome and plant growth using a cross-inoculation approach that reconstructed the interactions between nine Lotus accessions and four soil microbiomes under two different environmental conditions. We found that a large proportion of the root microbiome composition was determined by C and E and that G-related (G, G × C, and G × E) effects were significant but small. In contrast, the interactions between G and C had a more pronounced effect on plant shoot growth than C alone. Our findings indicate that most microbiome variations controlled by C have little effect on the plant phenotype, whereas G × C interactions have more significant effects. Plant genotype-dependent interactions with soil microbes warrant more attention in efforts to optimize crop yield and resilience.