Miracle-dz/UniFAR-FTUs huggingface dataset:
First-in-human dose-finding study of the ALK/EGFR inhibitor AP26113 in patients with advanced malignancies: Updated results.

8031 Background: AP26113 is a novel tyrosine kinase inhibitor (TKI) that potently inhibits mutant activated forms of anaplastic lymphoma kinase (ALK+) and epidermal growth factor receptor (EGFRm), and TKI-resistant forms including L1196M (ALK) and T790M (EGFR). AP26113 does not inhibit native EGFR. Methods: The dose finding phase (3+3 design) of this phase I/II open-label, multicenter study is ongoing in pts with advanced malignancies (except leukemia) refractory to available therapies or for whom no standard treatment exists. Initial dosing is orally once daily. Results: As of 14 Jan 2013, 44 pts were enrolled: 30 mg n=3, 60 mg n=3, 90 mg n=8, 120 mg n=8, 180 mg n=11, 240 mg n=9, 300 mg n=2; 64% female, median age 60 yrs; diagnoses: non-small cell lung cancer (NSCLC, n=37), other (n=7). 26 pts discontinued: 18 disease progression, 6 adverse event (AE), 2 deaths (sudden death, hypoxia; both possibly related). Most common AEs: nausea (45%), fatigue (39%), diarrhea (27%); most common grade 3/4 treatment-rel.
Toward a Recursive Stage-Based Framework for Supporting Startup Business Initiation: An Exploratory Study With Entrepreneurs

The recent success of startups resulted in an increasing interest concerning entrepreneurship approaches. However, there is a lack of studies with focusing on the understanding of how entrepreneurs experience these concepts and tools in practice. This paper investigates how entrepreneurs apply new entrepreneurship methodologies to create new businesses. Moreover, it aims at identifying the most important phases and activities. The research design is a survey-based research with a sample of 87 Brazilian startup entrepreneurs. As a result, a recursive stage-based framework for supporting startup initiation that combines concepts and tools from the lean startup, the business model canvas, and design thinking approaches are incorporated in recursive learning loops.
Crypt$\epsilon$: Crypto-Assisted Differential Privacy on Untrusted Servers

Differential privacy (DP) has steadily become the de-facto standard for achieving privacy in data analysis, which is typically implemented either in the"central"or"local"model. The local model has been more popular for commercial deployments as it does not require a trusted data collector. This increased privacy, however, comes at a cost of utility and algorithmic expressibility as compared to the central model. In this work, we propose, Crypt$\epsilon$, a system and programming framework that (1) achieves the accuracy guarantees and algorithmic expressibility of the central model (2) without any trusted data collector like in the local model. Crypt$\epsilon$ achieves the"best of both worlds"by employing two non-colluding untrusted servers that run DP programs on encrypted data from the data owners. Although straightforward implementations of DP programs using secure computation tools can achieve the above goal theoretically, in practice they are beset with many challenges such as poor performance and tricky security proofs. To this end, Crypt$\epsilon$ allows data analysts to author logical DP programs that are automatically translated to secure protocols that work on encrypted data. These protocols ensure that the untrusted servers learn nothing more than the noisy outputs, thereby guaranteeing DP (for computationally bounded adversaries) for all Crypt$\epsilon$ programs. Crypt$\epsilon$ supports a rich class of DP programs that can be expressed via a small set of transformation and measurement operators followed by arbitrary post-processing. Further, we propose performance optimizations leveraging the fact that the output is noisy. We demonstrate Crypt$\epsilon$'s feasibility for practical DP analysis with extensive empirical evaluations on real datasets.
Uncanny Valley in Video Games: An Overview

The uncanny valley is an idea proposed by Masahiro Mori (1970) regarding negative emotions present in contacts with almost humanlike characters. In the beginning, it was considered only in the context of humanoid robots, but this context was broadened by the development of highly realistic animations and video games. Particularly evident are players’ interests in the uncanny valley. Recently there have been a growing number of reports from empirical studies regarding participants’ perception of highly realistic characters. In the paper, a review of publications concerning the uncanny valley hypothesis in video games is presented, as are deliberations about the impact of the uncanny valley on the game industry. According to the results, there is a need to recognise which attributes of virtual characters cause the uncanny valley effect.
Knight Meets Sharpe: Capital Asset Pricing under Ambiguity

This paper extends the mean-variance preferences to mean-variance-ambiguity preferences by relaxing the assumption that probabilities are known, and instead assuming that probabilities are uncertain. The optimal portfolio is identified in general equilibrium, demonstrating that the two-fund separation theorem is preserved. Thereby, introducing ambiguity into the capital asset pricing model demonstrates that the ambiguity premium corresponds to systematic ambiguity, which is distinguished from the systematic risk. Using the closed-form measurable beta ambiguity, performance measures are generalized to account for ambiguity alongside risk. Use of this model can be extended to other applications including investment decisions and valuations. The introduced asset pricing model is empirically applicable and provides insight into empirical asset pricing anomalies.
Projected Gradient Descent for Non-Convex Sparse Spike Estimation

We propose a new algorithm for sparse spike estimation from Fourier measurements. Based on theoretical results on non-convex optimization techniques for off-the-grid sparse spike estimation, we present a projected gradient descent algorithm coupled with a back-projection initialization procedure. Our algorithm permits to estimate the positions of large numbers of Diracs in 2d from random Fourier measurements. We present, along with the algorithm, theoretical qualitative insights explaining the success of our algorithm. This opens a new direction for practical off-the-grid spike estimation with theoretical guarantees in imaging applications.
Coordination to choreography: the evolution of humanitarian supply chains

The purpose of this paper is to identify how coordination has evolved in humanitarian logistics (HL), what were the triggers for change and how have they been facilitated. ,This paper applies a systematic literature review of academic journals. ,This is the first paper to discuss the concepts of network orchestration and choreography in a humanitarian context. The research revealed that network coordination has moved on in the commercial sector to include orchestration and now, choreography concepts which have not been tested in HL literature. This reveals a lag exists between HL research and practice. ,This paper represents an exploratory study and provides the basis for further research on the concepts of orchestration and choreography in HL. The paper sets a research agenda for academics. ,This paper is the first to discuss the concepts of network orchestration and choreography in a humanitarian context. ,The areas of orchestration and choreography have received limited consideration within the humanitarian aid logistics literature to date. This paper is designed to redress this shortfall. As a result, it is hoped that it will act as a catalyst for further research and to widen and deepen the resultant debate with a view to improving the outcome for those affected by current and future disasters.
Epidynamics characterize and navigate the map of seizure dynamics

Seizures are a disruption of normal brain activity present across a vast range of species, diseases, and conditions. Here we introduce a mathematical theory, Epidynamics, which provides a conceptual framework to characterize how seizures start, evolve, and terminate. We provide the first objective taxonomy of seizures based on a straightforward analysis of EEG data. Analyzing over 2000 focal-onset seizures recorded from 7 epilepsy centers on five continents, we find evidence of the predicted 16 Dynamic Classes of seizures. The theory also enables drawing a map of brain dynamics that includes most seizure classes and status epilepticus. We demonstrate that patients navigate the map during their lifetime and verify critical predictions of the theory. Epidynamics not only provides a way to stratify patients in complement to present practical classifications but also guides biophysically based mechanistic approaches and provides a language to describe the most critical features of seizure dynamics.
WHAT DETERMINES THE QUALITY OD MARRIAGE? EMPIRICAL VALIDATION OF THE THEORETICAL MODEL

This study aimed to test the model set up by Obradovic and Cudina-Obradovic, according to which marital quality is determined by certain traits of marital quality from each of these groups of factors: the personality traits of the partners, the characteristics of the marriage, the marital processes and the marital environment. We operationalized this model, by testing the effect personality traits and the tendency towards alcohol consumption of marriage partners (as a personal characteristic of the marriage partner), the duration of the marriage (as the characteristic of the marriage itself), satisfaction with the division of household responsibilities (as one of the indicators of the development of the marital processes) and doubt regarding the marriage partner's fidelity (as the feature of the wider marital environment) have on the experienced marital quality. NEO-PI-R, The Dyadic Adjustment Scale and questionnaire designed for the aims of this study were used on a sample of 199 respondents from Serbia. Our model shows an excellent fit (X2 >.05; RMSEA .90; AGFI>.90; CFI>.90; NFI>.90). It can be concluded that Neuroticism, The Duration of marriage, Doubt regarding the partner’s fidelity and Dissatisfaction with the division of household responsibilities have a negative effect on marital quality.
Probiotics and Periodontal Disease: A Current Update

Probiotics are live micro-organisms that when administered in adequate amounts confer health benefits upon the host. Although a lot of work has been done regarding the effects of probiotic applications on systemic health particularly gastrointestinal, the impact of probiotics on oral health is relatively new with lots of research going on; the area of probiotics and periodontal disease is still in its infancy. The present article summarizes the role of probiotics in periodontal health and disease and its effectiveness in periodontal therapy.
Differences in Sense of Community Between Students in a Middle School Virtual Class Versus a Traditional Class

This study examined the difference between students’ sense of community in the traditional classroom setting versus the virtual classroom setting with middle school–age students. McMillan and Chavis’s sense of community theory served as the theoretical foundation of the study. A quantitative, causal-comparative design was utilized to determine the effects of the variables. Students at a public middle school in Virginia and a virtual middle school in Tennessee participated in this study. Seventy-eight students participated from the public middle school that constituted the traditional setting, and 60 students participated from the virtual middle school that constituted the virtual setting. The students completed the Sense of Community Index 2 (SCI-2) to generate the data for the study. Results of this survey were analyzed using a MANOVA, obtaining results for the students’ overall sense of community and the four subscales that made up this survey: reinforcement of needs, membership, influence, and shared emotional connection. Statistical significance was present, rejecting the null hypothesis or sub null hypothesis (post hoc) for the overall sense of community, reinforcement of needs, membership, and a shared emotional connection. The area of influence did not yield statistical significance; therefore, the sub null hypothesis (post hoc) failed to be rejected. Suggestions for future research were provided.
The Effect of Environmental Performance on Firm Value with Good Corporate Governance as a Moderator

Based on the theory of firm, the main purpose of a company is established is to maximize the wealth or value of the company. Changes in perception of corporate obligations have shifted since the advent of the stakeholder theory. The minimization of environmental damage caused by business activities and the protection of the natural environment is a signal of the company's environmental performance, and has received increasing attention from the community so environmental performance factor can affect company value. By understanding the relationship patterns between these two variables, it is hoped that companies can take the right steps in increasing the value of the company by contributing to the environment that is now a concern of the business world. However, the relation between two variables still inconsistent so this study uses good corporate governance as moderating variable. The study conducted on 37 manufacture company in Indonesian Stock Exchange and use Moderated Regression Analysis. The result of this study shows that environmental performance has no significant effect on firm value while good corporate governance that proxied by independent commissioner have no moderating effect. This can be an indication of the lack of environmental awareness owned by capital market investors so it is suggested that the active role of the government to raise awareness of environmental issues that occur at this time.
Is the Public Investment Multiplier Higher in Developing Countries? An Empirical Investigation

Over the last decade, empirical studies analyzing macroeconomic conditions that may affect the size of government spending multipliers have flourished. Yet, in spite of their obvious public policy importance, little is known about public investment multipliers. In particular, the clear theoretical implication that public investment multipliers should be higher (lower) the lower (higher) is the initial stock of public capital has not, to the best of our knowledge, been tested. This paper tackles this empirical challenge and finds robust evidence in favor of the above hypothesis: countries with a low initial stock of public capital (as a proportion of GDP) have significantly higher public investment multipliers than countries with a high initial stock of public capital. This key finding seems robust to the sample (European countries, U.S. states, and Argentine provinces) and identification method (Blanchard-Perotti, forecast errors, and instrumental variables). Our results thus suggest that public investment in developing countries would carry high returns.
RELATIONSHIPS BETWEEN SITE INDEX AND SOME EDAPHIC AND PHYSOGRAPHIC FACTORS OF PURE ORIENTAL SPRUCE (Picea orientalis Link.) IN ARTVİN GENYA MOUNTAIN

The aim of this study is to explain relationships between site index and some edaphic and physiographic factors of pure oriental spruce (Picea orientalis Link.) in Genya mountain located in central Management district in Artvin State Forest Enterprise. In order to do this study, the fifty sample plots were selected from oriental pure spruce stands in Genya Mountain. Edaphic and physiographic factors in each sample plots were determined. The soil profiles were digged to determine some attributes relating to soil. Also site index of each plots were determined using average height of dominant and co-dominant trees at reference age at 100. The relationships between site index and edaphic and physiographic factors were investigated using correlation analysis Among these ecological factors; slope, physical soil depth, absolute soil depth, the amount of silt and clay in Ah and B Stratus shows significant relations with site index.Keywords: Oriental Spruce, Site Index, Edaphic Factor, Physiographic Factor, Artvin.
The prevalence of obesity in a sample of Egyptian psychiatric patients

Background The relationship between mental health and obesity has been studied in different types of research studies as it is considered very important. A lot of research studies have proposed several theories and mechanisms on how the two are linked, which should be reviewed and considered in the management plan of psychiatric disorders. Objectives The aim of this study was to find out the prevalence and correlates of obesity and overweight in a sample of psychiatric patients (inpatients and outpatients) with no history of pharmacological treatment in Al-Hussein University Hospital. Patients and methods This cross-sectional study was conducted during a 6-month-period on 130 psychiatric patients who were subjected to a semistructured clinical interview according to DSM-IV-TR criteria to diagnose psychiatric disorders. Obesity assessment was carried out by measuring the weight (kg) using a scale and measuring the height (m) to calculate the BMI, which is based on the BMI equation Wt (kg)/Ht2 (m2). Results The prevalence of obesity and overweight in psychiatric patients was 66.93% (22.31% were obese, and 44.62% were overweight). The prevalence of obesity was highest in bipolar disorder (41.38%), followed by depression (37.93%), schizophrenia (10.34%), anxiety disorder (6.9%), and finally substance abuse disorder (3.45%), but the difference was not statistically significant. There was a significant correlation between sociodemographic characteristics of patients and obesity and the distribution of psychiatric disorders. Conclusion The prevalence of obesity and overweight in psychiatric patients was relatively high, and this can occur with most psychiatric disorders, especially mood disorders, and were supposed to be due to other several mechanisms and risk factors other than the effect of psychotropic medications on the weight of psychiatric patients. Moreover, there are some demographic and social factors that may moderate or mediate the association between obesity and psychiatric disorders; thus, identification of overweight and obesity, associated risk factors, and efforts to prevent weight gain should begin at the initiation of mental health treatment.
Large wood inhibits debris flow runout in forested southeast Alaska

Due to their potentially long runout, debris flows are a major hazard and an important geomorphic process in mountainous environments. Understanding runout is therefore essential to minimize risk in the near‐term and interpret the pace and pattern of debris flow erosion and deposition over geomorphic timescales. Many debris flows occur in forested landscapes where they mobilize large volumes of large woody debris (LWD) in addition to sediment, but few studies have quantitatively documented the effects of LWD on runout. Here, we analyze recent and historic debris flows in southeast Alaska, a mountainous, forested system with minimal human alteration. Sixteen debris flows near Sitka triggered on August 18, 2015 or more recently had volumes of 80 to 25 000 m3 and limited mobility compared to a global compilation of similarly‐sized debris flows. Their deposits inundated 31% of the planimetric area, and their runout lengths were 48% of that predicted by the global dataset. Depositional slopes were 6°–26°, and mobility index, defined as the ratio of horizontal runout to vertical elevation change, ranged from 1.2 to 3, further indicating low mobility. In the broader southeast Alaskan region consisting of Chichagof and Baranof Islands, remote sensing‐based analysis of 1061 historic debris flows showed that mobility index decreased from 2.3–2.5 to 1.4–1.8 as average forest age increased from 0 to 416 years. We therefore interpret that the presence of LWD within a debris flow and standing trees, stumps, and logs in the deposition zone inhibit runout, primarily through granular phenomena such as jamming due to force chains. Calibration of debris flow runout models should therefore incorporate the ecologic as well as geologic setting, and feedbacks between debris flows and vegetation likely control the transport of sediment and organic material through steep, forested catchments over geomorphic time. © 2020 John Wiley & Sons, Ltd.
Economic policy uncertainty and dividend sustainability: new insight from emerging equity market of China

Abstract We examine the influence of Economic Policy Uncertainty (E.P.U.) on dividend sustainability – dividend termination and dividend initiation decision. Using a sample of 1,375 firms over the time span 2000–2015, our main result reveals that during high E.P.U. past dividend payers are more likely to terminate and past non-payers are less likely to initiate dividends. However, firms that rely more on internal finance (I.F.), generate high return on invested capital (R.O.I.C.) and state-owned enterprises (S.O.E.s) are less exposed to E.P.U. Therefore, negative (positive) effect of E.P.U. on firms’ dividend initiation (termination) decision is mitigated by considering firms’ heterogeneous characteristics. Results also show that firms having high asset growth, maturity, profitability, cash holdings and high firm value are more likely to initiate and less likely to terminate dividend during period of high E.P.U. In addition, effects of E.P.U. on dividend sustainability is higher for firms functioning in high marketised areas relative to low marketised groups. These findings are robust under different robustness check. Finding confirms that transparent and stable implementation of economic policies can improve sustainability of firm’s dividend policy.
PRESENTEEISM OF CLASS TEACHERS: WELL-BEING AS A CRITICAL PSYCHOLOGICAL STATE IN THE MEDIATION OF JOB CHARACTERISTICS

ABSTRACT Purpose: Test job fulfillment as a mediator of the relationship between work design and presenteeism in teachers. Originality/value: Presenteeism is one of the reasons for teachers to underperform in the classroom. Many models explain organizational results, among which the Job Characteristics Model. That model, however, has not yet been tested with presenteeism, and, as it proposes, it will be predicted by work design mediated by positive work-related attitudes (i.e., eudaimonic well-being). Design/methodology/approach: A total of 2,282 public school teachers participated in the study, of which 71.1% were women. They completed the scale of job fulfillment, the Stanford Presenteeism Scale, and the full work design taxonomy in the Brazilian version. Direct and mediated relationships were tested, and the Job Characteristics Model was partially confirmed. Findings: For not completing work, mediation is confirmed only to the task identity subcategory of work design. Here, direct relationships with scheduling autonomy and social support were observed. For avoiding distraction, mediation occurred only for social support, and comfort at work. The subcategories decision-making autonomy, physical demands, and job complexity are directly related. We discuss the mediating role of critical psychological states and other positive triggers that could mediate the relationship between work design and organizational outcomes, such as emotions.