Miracle-dz/UniFAR-FTUs huggingface dataset:
The inherently three-dimensional nature of magnetized plasma turbulence

It is often asserted or implicitly assumed, without justification, that the results of two-dimensional investigations of plasma turbulence are applicable to the three-dimensional plasma environments of interest. A projection method is applied to derive two scalar equations that govern the nonlinear evolution of the Alfvénic and pseudo-Alfvénic components of ideal incompressible magnetohydrodynamic (MHD) plasma turbulence. The mathematical form of these equations makes clear the inherently three-dimensional nature of plasma turbulence, enabling an analysis of the nonlinear properties of two-dimensional limits often used to study plasma turbulence. In the anisotropic limit, k⊥ ≫ k∥, that naturally arises in magnetized plasma systems, the perpendicular 2D limit retains the dominant nonlinearities that are mediated only by the Alfvénic fluctuations but lacks the wave physics associated with the linear term that is necessary to capture the anisotropic cascade of turbulent energy. In the in-plane 2D limit, the nonlinear energy transfer is controlled instead by the pseudo-Alfvén waves, with the Alfvén waves relegated to a passive role. In the oblique 2D limit, an unavoidable azimuthal dependence connecting the wavevector components will likely cause artificial azimuthal asymmetries in the resulting turbulent dynamics. Therefore, none of these 2D limits is sufficient to capture fully the rich three-dimensional nonlinear dynamics critical to the evolution of plasma turbulence.
The importance of assessing and addressing mental health barriers to PrEP use during pregnancy and postpartum in sub‐Saharan Africa: state of the science and research priorities

Pregnant and postpartum women (PPW) in sub‐Saharan Africa are at disproportionately high risk of HIV infection compared to non‐pregnant women. When used consistently, pre‐exposure prophylaxis (PrEP) can prevent HIV acquisition and transmission to the foetus or infant during these critical periods. Recent studies have demonstrated associations between mental health challenges (e.g. depression and traumatic stress associated with intimate partner violence) and decreased PrEP adherence and persistence, particularly among adolescents, younger women and women in the postpartum period. However, mental health is not currently a major focus of PrEP implementation research and programme planning for PPW.
Complementary contribution of the medial and lateral human parietal cortex to grasping: a repetitive TMS study

Abstract The dexterous control of our grasping actions relies on the cooperative activation of many brain areas. In the parietal lobe, 2 grasp-related areas collaborate to orchestrate an accurate grasping action: dorsolateral area AIP and dorsomedial area V6A. Single-cell recordings in monkeys and fMRI studies in humans have suggested that both these areas specify grip aperture and wrist orientation, but encode these grasping parameters differently, depending on the context. To elucidate the causal role of phAIP and hV6A, we stimulated these areas, while participants were performing grasping actions (unperturbed grasping). rTMS over phAIP impaired the wrist orientation process, whereas stimulation over hV6A impaired grip aperture encoding. In a small percentage of trials, an unexpected reprogramming of grip aperture or wrist orientation was required (perturbed grasping). In these cases, rTMS over hV6A or over phAIP impaired reprogramming of both grip aperture and wrist orientation. These results represent the first direct demonstration of a different encoding of grasping parameters by 2 grasp-related parietal areas.
Cascaded likelihood vector coding of the LPC information

Cascade likelihood vector quantization is proposed for coding LPC spectral parameters for application in low-rate code-excited linear prediction systems. The approach is based on representing the LPC all-pole filter as a cascade of two lower-order all-pole filters. The partitioning of the LPC polynomial is done in the root domain by clustering the roots into two distinct groups. The quantizer uses two codebooks to quantize each of the lower-order filters. However, the quantization process is done so as to optimize jointly the performances of the two subsystems. The likelihood-ratio distortion measure is used as a performance criterion in the design and coding processes. Splitting the LPC filter into two subsystems dramatically reduces the coding complexity while the efficiency of using vector quantization is essentially preserved. Experimental results show an average performance of 1.59, 1.41, 1.24, and 1.10 dB log-spectral distortion at the rates of 1.0, 1.1, 1.2, and 1.3 kb/s, respectively. These figures represent good quality at 1.0 kb/s up to essentially transparent quality at 1.3 kb/s. <<ETX>>
A broadly conserved fungal alcohol oxidase (AOX) facilitates fungal invasion of plants

Abstract Alcohol oxidases (AOXs) are ecologically important enzymes that facilitate a number of plant–fungal interactions. Within Ascomycota they are primarily associated with methylotrophy, as a peroxisomal AOX catalysing the conversion of methanol to formaldehyde in methylotrophic yeast. In this study we demonstrate that AOX orthologues are phylogenetically conserved proteins that are common in the genomes of nonmethylotrophic, plant‐associating fungi. Additionally, AOX orthologues are highly expressed during infection in a range of diverse pathosystems. To study the role of AOX in plant colonization, AOX knockout mutants were generated in the broad host range pathogen Sclerotinia sclerotiorum. Disease assays in soybean showed that these mutants had a significant virulence defect as evidenced by markedly reduced stem lesions and mortality rates. Chemical genomics suggested that SsAOX may function as an aromatic AOX, and growth assays demonstrated that ΔSsAOX is incapable of properly utilizing plant extract as a nutrient source. Profiling of known aromatic alcohols pointed towards the monolignol coniferyl alcohol (CA) as a possible substrate for SsAOX. As CA and other monolignols are ubiquitous among land plants, the presence of highly conserved AOX orthologues throughout Ascomycota implies that this is a broadly conserved protein used by ascomycete fungi during plant colonization.
Detecting metrologically useful entanglement in the vicinity of Dicke states

We present a method to verify the metrological usefulness of noisy Dicke states of a particle ensemble with only a few collective measurements, without the need for a direct measurement of the sensitivity. Our method determines the usefulness of the state for the usual protocol for estimating the angle of rotation with Dicke states, which is based on the measurement of the second moment of a total spin component. It can also be used to detect entangled states that are useful for quantum metrology. We apply our method to recent experimental results.
Folding Features and Dynamics of 3D Genome Architecture in Plant Fungal Pathogens

Previously, our understanding of 3D genome architecture has mainly come from model mammals, insects, and plants. However, the organization and regulatory functions of 3D genomes in fungi are largely unknown. ABSTRACT The folding and dynamics of three-dimensional (3D) genome organization are fundamental for eukaryotes executing genome functions but have been largely unexplored in nonmodel fungi. Using high-throughput sequencing coupled with chromosome conformation capture (Hi-C) data, we generated two chromosome-level assemblies for Puccinia striiformis f. sp. tritici, a fungus causing stripe rust disease on wheat, for studying 3D genome architectures of plant pathogenic fungi. The chromatin organization of the fungus followed a combination of the fractal globule model and the equilibrium globule model. Surprisingly, chromosome compartmentalization was not detected. Dynamics of 3D genome organization during two developmental stages of P. striiformis f. sp. tritici indicated that regulation of gene activities might be independent of the changes of genome organization. In addition, chromatin conformation conservation was found to be independent of genome sequence synteny conservation among different fungi. These results highlighted the distinct folding principles of fungal 3D genomes. Our findings should be an important step toward a holistic understanding of the principles and functions of genome architecture across different eukaryotic kingdoms. IMPORTANCE Previously, our understanding of 3D genome architecture has mainly come from model mammals, insects, and plants. However, the organization and regulatory functions of 3D genomes in fungi are largely unknown. In this study, we comprehensively investigated P. striiformis f. sp. tritici, a plant fungal pathogen, and revealed distinct features of the 3D genome, comparing it with the universal folding feature of 3D genomes in higher eukaryotic organisms. We further suggested that there might be distinct regulatory mechanisms of gene expression that are independent of chromatin organization changes during the developmental stages of this rust fungus. Moreover, we showed that the evolutionary pattern of 3D genomes in this fungus is also different from the cases in mammalian genomes. In addition, the genome assembly pipeline and the generated two chromosome-level genomes will be valuable resources. These results highlighted the unexplored distinct features of 3D genome organization in fungi. Therefore, our study provided complementary knowledge to holistically understand the organization and functions of 3D genomes across different eukaryotes.
Effects of dietary calcium and phosphorus restrictions on growth performance, intestinal morphology, nutrient retention, and tibia characteristics in broiler chickens

ABSTRACT 1. This study evaluated the effects of dietary calcium (Ca)‎ and available phosphorus (aP) restrictions on growth performance, intestinal morphology, nutrient apparent total tract retention (ATTR), and tibia characteristics.2. A total of 1296, one-day-old male Ross-308 broilers were reared for 42 d. During the ‎starter phase (1-10 d), all birds were fed a nutrient-adequate diet (C). Diets fed during the grower phase (11-24 d) included: 1. C; 2. 15% of the Ca and aP in C; 3. 30% of the Ca and aP in C. At the beginning of the finisher phase (25 d), chickens fed the C diet were divided into two subgroups including C, and C+ phytase (500 FTU/kg). Restricted treatments were divided into eight subgroups as 1. C; 2. 10% of the Ca and aP in C; 3. 20% of the Ca and aP in C; 4. 30% of the Ca and aP in C; 5. C+ phytase; 6. 10% of the Ca and aP in C+ phytase; 7. 20% of the Ca and aP in C+ phytase and 8. 30% of the Ca and aP in C+ phytase. 3. On d 24 and 42, ATTR of Ca and phytate phosphorus (pP) were linearly increased by decreasing Ca and aP levels (P < 0.05). Birds receiving phytase showed higher nutrient ATTR ‎compared to those fed non-phytase supplemented diets (P < 0.05). Tibia Ca and P were linearly decreased at 24 d (P < 0.05) and tibial ash was linearly decreased (P < 0.05) at 42 d by decreasing levels of Ca and aP in finisher diets (without phytase)‎. By decreasing the levels of Ca and aP in the finisher diets (with phytase) with a 30% reduction of Ca and aP in the grower phase, tibia ash linearly decreased (P < 0.05). Using 500 FTU/kg phytase improved tibia traits compared to non-phytase supplemented treatments (P < 0.05). 4. In general, decreasing dietary Ca and aP (up to 30%) during grower and finisher phases increased ATTR of minerals and decreased Ca, P and breaking strength (BS) of tibia without any negative effect on growth performance or intestinal morphology. Reduced dietary Ca and aP decreased tibial ash content, although 500 FTU/kg phytase improved ATTR of minerals and tibia attributes.
Electrically charged strange quark stars

The possible existence of compact stars made of absolutely stable strange quark matter--referred to as strange stars--was pointed out by Witten almost a quarter of a century ago. One of the most amazing features of such objects concerns the possible existence of ultrastrong electric fields on their surfaces, which, for ordinary strange matter, is around 10{sup 18} V/cm. If strange matter forms a color superconductor, as expected for such matter, the strength of the electric field may increase to values that exceed 10{sup 19} V/cm. The energy density associated with such huge electric fields is on the same order of magnitude as the energy density of strange matter itself, which, as shown in this paper, alters the masses and radii of strange quark stars at the 15% and 5% levels, respectively. Such mass increases facilitate the interpretation of massive compact stars, with masses of around 2M{sub {center_dot}}, as strange quark stars.
The turbulent structure of the jet in cross-flow

In this thesis the structure of the jet in cross flow in the far field was investigated experimentally using time-resolved, multi-scale and statistically independent Stereoscopic Particle Image Velocimetry measurements to reveal the mean and instantaneous three-dimensional (3D) structures. All of the measurements were performed in the Counterrotating Vortex Pair (CVP) plane for a high velocity ratio and jet Reynolds number. Statistical measurements at various downstream locations and velocity ratios are presented. Probability density functions of the streamwise vorticity field showed that each CVP core is instantaneously made of a number of small vortex tubes rather than a single vortex core. The characteristic ‘kidney’ shape was illustrated in the rms velocity profiles and the Reynolds stress profiles exhibited a high level of organisation which showed an evolving shape with downstream distance and persisted well into the far field. Two point spatial correlations pointed to a common structure for all conditions whose mean shape generates the ‘kidney’ shape, as well as evidence of wake structures. Time-resolved measurements were carried out in a moving and stationary frame of reference, converted to 3D measurements via the use of Taylor’s hypothesis. The origin of the ‘kidney’ shape and large degree of spatial order in the far field was found to be a result of an organised ‘train’ of consecutive hairpin, roller and wake structures. Together, these structures provide a physical explanation that reconciles the statistical and instantaneous structure of the CVP.
1.3 μm InAs quantum dot laser with To=161 K from 0 to 80 °C

Data are presented on the influence of p-type modulation doping on the gain characteristics of 1.3 μm InAs quantum dot lasers. The improvement in optical gain leads to very high characteristic temperatures for the lasing threshold that reach 161 K in the temperature range between 0 and 80 °C. 1.3 μm ground state lasing is obtained up to a temperature of 167 °C.
Relativistic fluids and magneto-fluids

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Absolute stability and spatiotemporal long-range order in Floquet systems

Recent work has shown that a variety of novel phases of matter arise in periodically driven Floquet systems. Among these are many-body localized phases which spontaneously break global symmetries and exhibit novel multiplets of Floquet eigenstates separated by quantized quasienergies. Here we show that these properties are stable to all weak local deformations of the underlying Floquet drives -- including those that explicitly break the defining symmetries -- and that the models considered until now occupy sub-manifolds within these larger "absolutely stable" phases. While these absolutely stable phases have no explicit global symmetries, they spontaneously break Hamiltonian dependent emergent symmetries, and thus continue to exhibit the novel multiplet structure. The multiplet structure in turn encodes characteristic oscillations of the emergent order parameter at multiples of the fundamental period. Altogether these phases exhibit a form of simultaneous long-range order in space and time which is new to quantum systems. We describe how this spatiotemporal order can be detected in experiments involving quenches from a broad class of initial states.
The role of intellectual disability with autism spectrum disorder and the documented cooccurring conditions: A population‐based study

Previous research has identified that patterns of cooccurring conditions (CoCs) associated with autism spectrum disorder (ASD) differ based on the presence of intellectual disability (ID). This study explored the association of documented CoCs among 8‐year‐old children with ASD and ID (ASD+ID, n = 2416) and ASD without ID (ASD‐ID, n = 5372) identified by the Autism and Developmental Disabilities Monitoring Network, surveillance years (SYs) 2012 and 2014. After adjusting for demographic variables, record source, surveillance site, and SY, children with ASD+ID, as compared with children with ASD‐ID, were more likely to have histories of nonspecific developmental delays and neurological disorders documented in their records but were less likely to have behavioral and psychiatric disorders. ID plays a key role on how children with ASD would experience other CoCs. Our results emphasize how understanding the pattern of CoCs in ASD+ID and ASD‐ID can inform comprehensive and multidisciplinary approaches in assessment and management of children in order to develop targeted interventions to reduce possible CoCs or CoCs‐related impairments.
Burden and mortality of sepsis and septic shock at a high-volume, single-center in Vietnam: a retrospective study

ABSTRACT Background Sepsis and septic shock have high mortality rates and often require a prolonged hospital stay. Patient outcomes may vary according to multiple factors. We aim to determine the prevalence of antimicrobial resistance and factors associated with mortality and hospital stay. Methods Clinical and microbiological data of patients with sepsis or septic shock were retrospectively collected for 15 months. Patients with negative blood cultures and patients that did not meet the SEPSIS 3 criteria were excluded. Results We included 48 septic shock and 28 septic patients (mean APACHE II 20.32 ± 5.61 and mean SOFA 9.41 ± 3.17), with a mean age of 60.5 ± 16.8 years and 56.6% males. WBCs, neutrophils, INR, and fibrinogen levels were significantly associated with mortality. 59.5% of the cultured bacteria were gram-negative (most common E. coli) and 27.8% were gram-positive (most common S. aureus), while 7.6% were other types of bacteria and 5.1% were fungi. Resistance patterns to gram-negative were varying, and resistance to piperacillin/tazobactam, carbapenems, and aminoglycosides were from 60% to 100% (A. baumanii), while they were highly sensitive to Colistin. E. coli was also resistant to ceftriaxone (77.8%) and sulbactam/cefoperazone (44.4%). Resistance rates for Gram-positives were high, from 86% to 100% for oxacillin, while for vancomycin, teicoplanin, and linezolid, they were often low but arrived up to 42.8%. According to our logistic regression analysis, patients over 65 year-old and those who received corticosteroids had a significantly increased risk of in-hospital mortality (OR: 4.0; OR: 4.8). Conclusion Sepsis still poses a significant threat to patients’ health, even when positive blood culture results allow the administration of specific antibiotic treatment.
Patient Voices in Hospital Safety during the COVID-19 Pandemic

Hospitalized patients and their families may be reluctant to express safety concerns. We aimed to describe safety and quality concerns experienced by hospitalized patients and families and factors and outcomes surrounding decisions about voicing concerns, including those related to the COVID-19 pandemic. We conducted semi-structured interviews with 19 discharged inpatients or family members in a qualitative descriptive design. Some participants reported concern about staff competency or knowledge, communication and coordination, potential treatment errors, or care environment. Factors influencing feeling safe included healthcare team member characteristics, communication and coordination, and safe care expectations. Reasoning for voicing concerns often included personal characteristics. Reasons for not voicing concerns included feeling no action was needed or the concern was low priority. Outcomes for voicing a concern were categorized as resolved, disregarded, and unknown. These findings support the vital importance of open safety communication and trustworthy response to patients and family members who voice concerns.
Platelet‐rich plasma versus corticosteroid injections in the management of patients with rotator cuff disease: A systematic review and meta‐analysis

Platelet‐rich plasma (PRP) is an alternative to corticosteroid (CS) injections in managing rotator cuff disease. This meta‐analysis investigated differences between PRP and CS for function and pain scores in significance and minimal clinical important difference (MCID). A literature search of Ovid Cochrane Library, Medline, Embase, Epub, and Scopus was conducted from inception to October 28, 2021. Eligible studies reported patients older than 18 years with a diagnosis of rotator cuff disease. This review was registered in PROSPERO (ID: CRD42021278740). Twelve studies met eligibility criteria (n = 639) of patients receiving either PRP or CS. At short‐term follow‐up, a difference favored CS compared to PRP in baseline change for disability of arm, shoulder, and hand (DASH) score (MD = −5.08, 95% CI: −8.00, −2.15; p = 0.0007; I2 = 0%) and simple shoulder test (SST) (MD = 1.25, 95% CI: 0.33, 2.18; p = 0.008; I2 = 0%). At intermediate follow‐up, a difference favored PRP to CS baseline change of the DASH score (MD = 3.41, 95% CI: 0.67, 6.15; p = 0.01; I2 = 0%). At medium‐term, a difference favored PRP to CS baseline change of the American Shoulder and Elbow Surgeons Shoulder (ASES) score (MD = −4.42, 95% CI: −8.16, −0.67; p = 0.02; I2 = 0%). Both treatments achieved individual MCID for each score. Despite favoring CS at short‐term follow‐up and PRP at intermediate‐ and medium‐term follow‐up, functional and pain scores did not demonstrate any clinical difference between the two treatment modalities in management of rotator cuff disease at all follow‐up periods.