Miracle-dz/UniFAR-FTUs huggingface dataset:
A Nomogram Based on SEER Database for Predicting Prognosis in Patients with Mucinous Ovarian Cancer: A Real-World Study

Purpose Mucinous ovarian cancer (MOC) is a rare histological type of EOC. In order to guide the clinical diagnosis and management of MOC patients, we constructed and verified a nomogram for the estimation of overall survival in patients with MOC. Patients and Methods We collected 494 patients with MOC diagnosed from 2010 to 2015 in SEER database, and the following main inclusion criteria were used: (1) patients whose MOC was confirmed by pathology; (2) patients without a history of primary other cancer. Subsequently, we performed randomized grouping (6:4) and Cox hazard regression analysis in the training group. Subsequently, the nomogram was established. A variety of indicators were used to validate the prognosis value of nomogram, including the C-index, area under the receiver operating characteristic curve, calibration curve, and decision curve analysis (DCA). Moreover, Kaplan–Meier analysis was used to compare the survival results among different risk subgroups. Results Cox hazard regression analysis revealed that age, grade, FIGO stage and log odds of positive lymph nodes stage were independent risk factors for patients with MOC. In the training group, the C-index of the nomogram was 0.827 (95% CI: 0.791–0.863) and the areas under the curve (AUC) predicting the 1-, 3- and 5-year survival rate were 0.853 (95% CI: 0.791–0.915), 0.886 (95% CI: 0.852–0.920) and 0.815 (95% CI: 0.766–0.864), respectively. The calibration curve revealed that the nomogram of the 1-, 3- and 5-year survival rate was consistent with the actual fact. Patients with high risk had a poorer prognosis than those with low risk (P < 0.001). DCA revealed that the nomogram had the best clinical value than other classical prognostic markers. Similarly, nomogram had excellent prognostic ability in the testing group. Conclusion The nomogram was constructed to predict overall survival in patients with MOC, which had the significance for clinical evaluation.
A Unified System Residual Life Prediction Method Based on Selected Tribodiagnostic Data

This paper proposes a new systematic method for assessing system material wear to build a system degradation model and estimate residual technical life. Selected metal wear debris from lubricating oil, which contains information about the lubricant conditions and system conditions, is analyzed. We focus on the iron (Fe) and copper (Cu) debris, which we (and other researchers) consider to be valuable, of the contact degradation and wear failure systems. By monitoring the changes in debris content in the lubricating oil, we build a system degradation model and further predict the moment when the system no longer fulfills its functions; the residual life might then be set as the time reference to implement preventive maintenance. The degradation model is founded on the specific characteristics of a stochastic diffusion process with bivariable, using the bivariate Wiener process with a time scale transformation. An inference function to describe the dependency among the selected wear debris was also applied because the oil field data exhibit some uncertainty and correlation. Based on the degradation modeling results, the system reliability curve and the failure probability density curve predict the MTBF value and the expected mean residual life can be obtained, and provide the foundations for the condition-based maintenance of the system. However, the potential applications of the results are much broader. For instance, the results can be used as inputs to mission plan optimization and further reduce system maintenance costs.
Relationship Between the Nonlinear Oscillator and the Motor Cortex

The investigations show that the fractional calculus could be employed for complex biological systems and capture intrinsic phenomena. At the same time, the research results also show that the neural network has the characteristics of fractional calculus and its neuronal dynamics is complex. As a micro-neural circuit placed in the spinal cord, the central pattern generator (CPG) is supposed to have the property of fractional calculus. In order to study the application of the fractional order technique to the CPG, the fractional order CPG model is established based on the Matsuoka model. The stable conditions are given through mathematical analysis. In order to extract the relation between the motor cortex and the fractional order CPG, the coupling model between the fractional order CPG and the neural mass model (NMM) simulated the motor cortex is built. Moreover, the effects of coupling model parameters variations on the CPG and the NMM are investigated. The main findings are: first, the CPG output obtained with the fractional order is more accurate than the one obtained with the integral order. Increasing the fractional order makes the CPG output more accurate. Second, the results show that the motor cortex has corresponding modes with those of the CPG. And the NMM mode can switch in accordance with the change of fractional order. Third, the simulations also show that a new stable state in motor cortex could be produced based on the existing modes with the introduction of the fractional order CPG model. It can provide a helpful method to understand the working principles of the motor cortex.
Cultura da segurança do paciente na atenção primária à saúde

The aim of this study was to analyze the attitudes that demonstrate the safety culture by the professionals of the Family Health Strategy and Community Health Agents Program. The Safety Attitudes Questionnaire was applied with 96 professional of the Nursing Team and Community Health Agents in Florianopolis city, in order to evaluate nine safety attitudes. Teamwork Climate, Working Conditions, Communication and Perceptions of Management presented a p-value ≤0.05, showing significance for the patient safety culture. However, these same four safety attitudes were assessed differently by the Community Health Agents in relation to the nurses and nursing technicians. In the sample analyzed, the attitude Patient Safety was considered the most important by the three professional categories, and the variable with less relevance for these categories was the Error attitude. DESCRIPTORS: Culture. Safety. Primary healthcare. Nursing team.
Feasibility and robustness of an oral HIV self-test in a rural community in South-Africa: An observational diagnostic study

Background HIV-self-testing (HIVST) could be a strategy to get more people tested for HIV in resource limited settings. One of the prerequisites of a successful HIVST programme is the availability of an easy to use, valid HIV-test which is robust against field conditions and procedural errors by untrained lay users. Methods and findings The primary objective of this study was to evaluate the ability of untrained persons to correctly interpret the OraQuick HIV Self-Test results with oral fluid compared with results obtained by trained users using the matched lot OraQuick Rapid HIV-1/2 Antibody Test and blinded to the results of the Self-Test. Sensitivity of the OraQuick HIV Self-Test in untrained users was 101 in 102 (99.02%; 95%CI = 93.88–99.95%)—and specificity– 1,241 in 1,241 (100.0%; 95%CI = 99.62–100.0%). Forty-eight Self-Tests were excluded in the accuracy analysis (due to a result read as invalid, not sure or ambiguous) resulting in a test system failure rate of 3.45% (95% CI 2.56%-4.55%). At least one observation of difficulty or error with one or more of the test steps were seen in 1,193 (84.6%) participants. Age, education and health literacy were independently associated with the sum score of procedural errors and difficulties. Four tests did not provide a valid result as determined by the trained user’s interpretation of the Self-Test. Conclusions The OraQuick HIV Self-Test provides reliable and repeatable results in a rural field environment in spite of procedural errors.
Quasi-N4-lattices and their logic

The variety of quasi-N4-lattices (QN4) was recently introduced as a non-involutive generalization of N4-lattices (algebraic models of Nelson's paraconsistent logic). While research on these algebras is still at a preliminary stage, we know that QN4 is an arithmetical variety which possesses a ternary as well as a quaternary deductive term, enjoys equationally definable principal congruences and the strong congruence extension property. We furthermore have recently introduced an algebraizable logic having QN4 as its equivalent semantics. In this contribution we report on the results obtained so far on this class of algebras and on its logical counterpart.
Backscattered electron emission after proton impact on gold nanoparticles with and without polymer shell coating

This work aims at measuring experimentally proton induced secondary electron energy spectra after interaction with gold nano particles (GNPs) and polymer-coated GNPs. Backscattered electron energy spectra were collected over a 0 to 1000 eV energy range using a retarding field analyzer (RFA). This paper presents the spectra obtained for proton beam energies of 0.5 and 2 MeV and diameter 2.5 and 3.8 nm GNPs. The spectra were also measured for 3.8 nm GNPs after 5 and 10 MeV proton irradiations. GNPs were deposited on a 100 nm carbon film. Each experimental spectrum was compared with dedicated simulations based on existing numerical models used in the TRAX and Geant4 Monte Carlo codes. For 100 nm carbon target, good agreement between experimental, TRAX and Geant4 simulation results can be observed. For 3.8 nm GNPs, the TRAX simulations reproduce with good agreement the electron energy spectra produced after 0.5, 2, 5 and 10 MeV proton irradiations, while Geant4 spectra display a lower secondary electron yield at low energy (<600 eV) for all the studied energies. This underestimation can mostly be explained by the 790 eV threshold applied in the condensed history model used by Geant4 which impacts the secondary electron energy distribution. Results obtained for carbon and gold targets highlight the impact of the secondary electron production threshold for proton ionization process considered in condensed history models. The experimental results demonstrate that the single interaction approach used in TRAX is adapted to reproduce secondary electron emission from GNPs. On the other hand, the standard electron generation threshold implement in G4BetheBlochModel and G4BraggModel condensed-history models used in Geant4 is not adapted to reproduce low energy electron emission in gold targets. Finally, the results highlight that the GNP coating leads to a decrease of the electron yield and mostly affects low energy electrons (<500 eV) emitted from GNPs.
Plasma Lactate as a Predictor of Colonic Viability and Survival After 360° Volvulus of the Ascending Colon in Horses

OBJECTIVES: To determine the relationship between plasma lactate concentration and colonic viability and survival in horses with >or=360 degrees volvulus of the ascending colon. STUDY DESIGN: Retrospective study. ANIMALS: Horses (n=73) with >or=360 degrees volvulus of the ascending colon. METHODS: Medical records (January 2000-November 2005) of all horses examined for colic at Michigan State University Veterinary Teaching Hospital were reviewed. Horses were included only if plasma lactate concentration was measured preoperatively and a diagnosis of >or=360 degrees volvulus of the ascending colon was confirmed by surgery or necropsy. Non-survivors were only included if the ascending colon was evaluated histopathologically. Logistic regression analysis was used to model the relationship between lactate, colonic viability, and survival. RESULTS: Of 73 horses, 61 were discharged. Mean (+/-SD) plasma lactate concentration was significantly lower in survivors (2.98+/-2.53 mmol/L) compared with non-survivors (9.48+/-5.22 mmol/L; odds ratio [OR]=1.628, 95% confidence limit [CI]=1.259-2.105). Plasma lactate concentration was significantly lower in horses with a viable colon (3.30+/-2.85 mmol/L) compared with horses with a non-viable colon (9.1+/-6.09 mmol/L; OR=1.472, 95% CI=1.173-1.846). Plasma lactate concentration or=360 degrees volvulus of the ascending colon. CLINICAL RELEVANCE: Plasma lactate concentration may help predict colonic viability and horse survival after ascending colon volvulus in horses.
Effect of Water Precautions on Otorrhea Incidence after Pediatric Tympanostomy Tube: Randomized Controlled Trial Evidence

Objectives Tympanostomy with ventilation tube insertion is the most common otologic surgery. Many surgeons recommend water precautions, although its utility is questioned. We aimed to investigate if water precautions reduce the rate of otorrhea after transtympanic tube insertion. Study Design Multicenter randomized controlled trial. Subjects and Methods A total of 244 children aged 2 to 10 years undergoing their first set of Shepard tubes for otitis media with effusion and concomitant adenoidectomy were randomized to 2 groups: 1 with ear protection during water exposure (ear plugs and headbands, n = 130) and 1 without (n = 114). Bathing or swimming with unprotected ears was considered the exposure event and incidence of otorrhea, the primary outcome. Outcomes were assessed during the 6-month follow-up period. Results In the water precaution group, 32% had at least 1 episode of otorrhea as compared with 22% in the unprotected group, which was not statistically significant (P = .09). Only 37% of the episodes of otorrhea in the protected group and 36% in the unprotected group had a temporal relation to water exposure (no difference, P = .81). Respectively, 56% and 52% of the episodes of otorrhea were in the context of upper respiratory tract infection. Global quality of life improved significantly, irrespective of whether water protection was prescribed. Conclusion The incidence of otorrhea was not different with or without prescription of ear protection during water exposure among children with tympanostomy tubes, which supports current guideline recommendations that routine water precautions are unnecessary in this population.
The Making of an Addiction: Examining Psychological Determinants of Prescription Stimulant Abuse among College Students

ABSTRACT Diagnoses of attention-deficit-disorders and stimulant prescriptions to treat these disorders (e.g., Adderall) are on the rise. The non-medical use of such stimulants (NUPS) as ‘study drugs’ has increased among college students, which aggravates the worsening prescription drug crisis in the U.S. This research examined the underlying psychological determinants of NUPS in order to inform effective health communication intervention efforts. It also tested potential individual-level characteristics that could influence such determinants in order to determine at-risk groups. This research utilized the reasoned action framework in a mixed-methods, two-study approach. Study 1 explored the underlying beliefs associated with intentions to engage in NUPS in an open-ended belief elicitation survey (N = 121), study 2 (N = 312) tested the psychological determinants of intentions and influencing individual-level characteristics in a quantitative survey. Results revealed (1) the top three unique attitudinal, normative, and control beliefs about NUPS; (2) instrumental attitude as strongest determinant of NUPS; (3) expectations of improved productivity, approval from friends and peers, access and financial means, peer pressure, and health risks as effective targets for effective health communication interventions; and (4) poor mental health, high levels of stress, and characteristics of perfectionism and sensation-seeking as aggravating risk factors among college students. Further implications and directions are discussed.
A passage through mirrors: the construction of the nurse's professional identity

The subject is the construction of the nurse’s professional identity, in three moments, understood as passages through a mirror: the periods before the university entrance; during the university studies; and after graduation. A qualitative approach was used and Scenes of Aesthetic Production was used as a methodological strategy for data production. The analysis was based on multi-referentiality and on social representations. The passage through the 1st mirror is “The death of the teenage dream”; the 2nd mirror, “The construction of the resistance identity”; the 3rd mirror, “The construction of the project identity”. We came to the conclusion that construction of the professional identity of the nurse is a dynamic process that is in the process of shifting emphasis to identification with the self, the intersubjectivity of the human action, as a function of social well-being, liberty of expression, and the preservation of environmental equilibrium. RESUMEN: El estudio trata de la construcción de la identidad profesional de la enfermera, en 3 momentos, entendidos estos como pasajes por los espejos: el período anterior al ingreso en la universidad; durante la formación académica y posterior a la graduación. El estudio de naturaleza cualitativa, las estrategias metodológicas para la producción de los datos fueron las Escenas de Producción Estética. El análisis fue hecho a la luz de la multireferencialidad y de las representaciones sociales. En el Pasaje por el 1o espejo emergió, “La muerte del sueño adolescente”, en el 2o espejo la “Construcción de la identidad de resistencia” en el 3o espejo: “La construcción de la identidad de proyecto”. Concluimos que la construcción de la identidad profesional de la enfermera es un proceso dinámico en donde, actualmente, desplaza su eje principal para la auto-identificación, la intersubjetividad de la acción humana, en función del bienestar social, de la libertad de expresión y de la preservación del equilibrio ecológico. PALAVRAS-CHAVE: Enfermagem. Escolha da profissão. Cultura.
Supervised Dictionary Learning for Block Threshold Feature in Compressive Spectrum Sensing

With the development of communication systems towards the high-frequency band, the demand for spectrum resources is ever-increasing, where the research interest has changed from narrowband spectrum sensing to wideband spectrum sensing. The Nyquist-rate-based wideband spectrum sensing with high-rate sampling is being questioned whether it is suitable for real-time applications. On the contrary, the well-known compressive spectrum sensing (CSS) is more appealing due to the compressive sensing (CS) technology, resulting in lower signal acquisition costs. However, the CS algorithms for recovering sparse spectrum generally require multiple iterations, which presents a challenge to the low complexity implementation of spectrum sensing. To address this issue, this paper proposes a novel method for solving the block CSS (BCSS) problem, where the spectrum of primary users is modeled as a block structure signal. Specifically, the block threshold feature (BTF) is utilized to reconstruct the spectrum while bypassing any iterative operations. Furthermore, to improve the performance of the BTF-based BCSS, we develop a novel supervised dictionary learning (SDL) model, based on the theoretical analysis of mutual incoherence and restricted isometry properties. Simulation results not only verify the compatibility of BTF and the SDL model, but also demonstrate the effectiveness and robustness of SDL-BTF-based BCSS for practical implementation.
Index to degree of adhesion to good practices of corporate governance and their effect on financial performance: evidence for Chilean companies

Over recent decades, numerous financial crises have affected the global economy, which were caused by the lack of ethical values and conflicts of interest amongst the leaders of organisations. To protect organisations and their interest groups, regulators have developed norms to discourage and prohibit unethical practices through promotion of good practices of corporate governance. However, the literature on good corporate governance practices focuses mainly on developed economies without considering the challenges of developing countries. Therefore, this research proposes an index to measure the degree of adherence to good corporate governance practices in an emerging economy, like Chile, and estimate its effect on the financial performance of companies. Through a panel analysis, this research provides evidence that shows the existence of a positive and significant relationship between this index and financial performance of organisations, as well as a persistence of its benefits over time when companies adopt good practices.
Hippocampal Stratum Oriens Somatostatin-Positive Cells Undergo CB1-Dependent Long-Term Potentiation and Express Endocannabinoid Biosynthetic Enzymes

The hippocampus is thought to encode information by altering synaptic strength via synaptic plasticity. Some forms of synaptic plasticity are induced by lipid-based endocannabinoid signaling molecules that act on cannabinoid receptors (CB1). Endocannabinoids modulate synaptic plasticity of hippocampal pyramidal cells and stratum radiatum interneurons; however, the role of endocannabinoids in mediating synaptic plasticity of stratum oriens interneurons is unclear. These feedback inhibitory interneurons exhibit presynaptic long-term potentiation (LTP), but the exact mechanism is not entirely understood. We examined whether oriens interneurons produce endocannabinoids, and whether endocannabinoids are involved in presynaptic LTP. Using patch-clamp electrodes to extract single cells, we analyzed the expression of endocannabinoid biosynthetic enzyme mRNA by reverse transcription and then real-time PCR (RT-PCR). The cellular expression of calcium-binding proteins and neuropeptides were used to identify interneuron subtype. RT-PCR results demonstrate that stratum oriens interneurons express mRNA for both endocannabinoid biosynthetic enzymes and the type I metabotropic glutamate receptors (mGluRs), necessary for endocannabinoid production. Immunohistochemical staining further confirmed the presence of diacylglycerol lipase alpha, an endocannabinoid-synthesizing enzyme, in oriens interneurons. To test the role of endocannabinoids in synaptic plasticity, we performed whole-cell experiments using high-frequency stimulation to induce long-term potentiation in somatostatin-positive cells. This plasticity was blocked by AM-251, demonstrating CB1-dependence. In addition, in the presence of a fatty acid amide hydrolase inhibitor (URB597; 1 µM) and MAG lipase inhibitor (JZL184; 1 µM) that increase endogenous anandamide and 2-arachidonyl glycerol, respectively, excitatory current responses were potentiated. URB597-induced potentiation was blocked by CB1 antagonist AM-251 (2 µM). Collectively, this suggests somatostatin-positive oriens interneuron LTP is CB1-dependent.