Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards Optimized Discovery of Service Combinations without Collisions

: Majority of service discovery research considers only primitive services as a suitable match for a given query while service combinations are not allowed. However, many realistic queries cannot be matched by individual services and only a combination of several services can satisfy such queries. Allowing service combinations or proper compositions of primitive services as a valid match introduces problems such as unwanted side-eﬀects (i.e., producing an eﬀect that is not requested), eﬀect duplications (i.e., producing some eﬀect more than once) and contradictory eﬀects (i.e., producing both an eﬀect and its negation). Also the ranking of matched services has to be reconsidered for service combinations. In this report, we address all the mentioned issues and present an optimized matchmaking algorithm for retrieval of the best top k collision-free service combinations satisfying a given query.
ICASH-A04 DEVELOPMENT OF MYANMAR CARBOHYDRATE COUNTING BOOKLET

Background : Diabetes mellitus is one of the major challenging problems in Myanmar. Even with its high occurrence, the prevalence of good glycemic control was relatively low. According to Myanmar food culture, most of the foods that Myanmar people daily consumed are carbohydrate-based. Therefore, a nutrition education tool that can raise the awareness of amount of carbohydrate in foods and provide scientific but comprehensible dietary information about carbohydrate counting is necessary in all arenas to combat diabetes: prevention, promotion and management. Aim: The aim of this study was to develop Myanmar carbohydrate counting booklet. Method: The first phase developed the booklet and then the acceptance of the booklet was assessed in the second phase by an experimental study. Results: In the first phase, the booklet named “Basic Carb Counting for People Living with DM” was developed. It was 14.5 × 20.5 × 1 cm in size and of 103 pages. It contained illustrated facts and information about diabetes, about basic carb counting and carb choices of different food items along with respective food photographs. In the second phase, 36 people with diabetes participated in the study with the mean age of 48.4 ± 10.7 years, 47.2% of male and 52.8% of female. The results showed that the knowledge score of diabetes, carbohydrate and total scores increased significantly (p <0.05) between pre-test score and post-test score. The participants’ satisfaction level with the newly developed booklet was somewhere between “very satisfied” to “extremely satisfied” giving the mean and median responses of between 5 and 6 on a 6-point Likert scale. Conclusion: The developed carbohydrate counting booklet was accepted by people with diabetes in Myanmar and the contents in the booklet were understandable to witness the improvement in the knowledge of the disease and basic carbohydrate counting concept as well.
cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.

Background: The sustained clinical activity of the BRAF inhibitor vemurafenib (PLX4032/RG7204) in patients with BRAF V600 mutant melanoma is limited primarily by the development of acquired resistance leading to tumor progression. Clinical trials are in progress using MEK inhibitors following disease progression in patients receiving BRAF inhibitors. However, the PI3K/AKT pathway can also induce resistance to the inhibitors of MAPK pathway. Methodology/PrincipalFindings: The sensitivity to vemurafenib or the MEK inhibitor AZD6244 was tested in sensitive and resistant human melanoma cell lines exploring differences in activation-associated phosphorylation levels of major signaling molecules, leading to the testing of co-inhibition of the AKT/mTOR pathway genetically and pharmacologically. There was a high degree of cross-resistance to vemurafenib and AZD6244, except in two vemurafenib-resistant cell lines that acquired a secondary mutation in NRAS. In other cell lines, acquired resistance to both drugs was associated with persistence or increase in activity of AKT pathway. siRNA-mediated gene silencing and combination therapy with an AKT inhibitor or rapamycin partially or completely reversed the resistance. Conclusions/Significance: Primary and acquired resistance to vemurafenib in these in vitro models results in frequent cross resistance to MEK inhibitors, except when the resistance is the result of a secondary NRAS mutation. Resistance to BRAF or MEK inhibitors is associated with the induction or persistence of activity within the AKT pathway in the presence of these drugs. This resistance can be potentially reversed by the combination of a RAF or MEK inhibitor with an AKT or mTOR inhibitor. These combinations should be available for clinical testing in patients progressing on BRAF inhibitors.
A dual-band flexible frequency selective surface with miniaturized elements and maximally flat (Butterworth) response

A dual-band flexible frequency selective surface (FSS) with miniaturized elements and maximally flat (Butterworth) response is presented in this paper. It is composed of three metallic layers, which are fabricated on thin flexible polyimide substrates and bonded together using thin bonding films. The overall thickness of the proposed structure is only about 0.3 mm, making it an attractive choice for conformal FSS applications. All the three layers can constitute a miniaturized-element FSS (MEFSS) and produce the first pass-band with miniaturization property, while the up and bottom layers can constitute a symmetric biplanar FSS and produce the second pass-band with maximally flat (Butterworth) response. The two pass-bands are independent and there is a wide band spacing up to 30 GHz between them. The principles of operation, the simulated results by using the vector modal matching method, and the experimental values of the fabricated prototype are also presented and discussed.
An Optical Combination Method for Resolving Axial and Transverse Force Interference Using Tapered Fiber Bragg Grating

Crosstalk noise between the two force components (axial and transverse) and temperature is always present when the fibre Bragg grating (FBG) sensor technology is utilized in many sophisticated equipment. To address this, we proposed a theoretical method that decouples the two force components while eliminating the effect of temperature, using a combination of modified FBGs and a bandwidth modulation mechanism. Our previous study showed the first step in our continuous effort to prove the concept. In this study, the second part of proving the decoupling approach while avoiding the temperature effect is proved experimentally. In addition to the tapered FBG (TFBG) in its neutral axis, a hollow shaft prototype that resembles the construction of several medical surgery equipment is being developed further to include a linear chirped FBG (CFBG) along its shaft's surface. The experimental results demonstrate that the estimated axial and transverse force values are consistent with their actual values, with RMS errors of less than 0.32 N and less than 0.16 N, respectively, over the range of (0 N – 10 N). The presented method can potentially be extended to small surgical instruments such as ophthalmia’s needle and ablation catheter.
CIA_A_279535 2353..2361

1Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2General Surgery, Nanchang Third Hospital, Nanchang, People’s Republic of China; 3Department of Biochemistry, Medical College of Georgia, Augusta, GA, USA Background: Leptin, an adipokine, has effects on the cardiovascular system with both protective and harmful role. This study aimed to assess the relationship between leptin and 3-month prognosis in ischemic stroke patients with type 2 diabetes. Patients and Methods: As a prospective single-center observational study, we collected consecutive first-ever acute ischemia stroke with type 2 diabetes mellitus from February 2019 to February 2020. Serum samples were obtained at admission, and leptin serum levels were tested by the ELISA method. Logistic regression models were used to assess leptin’s prognostic value to predict the functional outcome and mortality within three months. Results: Finally, two hundred and eleven patients were included, and the mean leptin serum level was 16.8 (SD. 6.9) ng/mL. At admission, 53.6% of those included patients (N=113) were defined as severe stroke (NIH Stroke Scale [NIHSS]>5). In multivariable models adjusted for other factors, leptin levels<11.6ng/mL (lowest quartile, Q1) related to severe stroke and the risk increased 175% (odds ratios [OR] =2.75; 95% confidence interval [CI] =2.13–3.38; P=0.002). Serum leptin levels on admission in patients with poor outcomes and nonsurvivors were significantly reduced (P<0.001 and P<0.001). Leptin levels <11.6ng/mL (lowest quartile, Q1) related to a higher risk of poor functional impairment (OR=5.13; 95% CI =3.25–6.86; P<0.001) and mortality (OR=3.19; 95% CI =2.03–4.25; P<0.001). Conclusion: The data shows that leptin serum level is a useful prognostic biomarker in ischemic stroke patients with type 2 diabetes, and this relationship is negative.
Recently Strengthened Inﬂuence of ENSO on the Wintertime East Asian Surface Air Temperature

: Previous studies have indicated that El Niño–Southern Oscillation (ENSO) exerts a signiﬁcant inﬂuence on the East Asian winter climate. This study reveals an interdecadal strengthening of the connection between ENSO and the East Asian surface air temperature (EAT) connection around the late 1990s and investigates the reason for this change. Before the late 1990s, the inﬂuence of ENSO on the EAT was weak, and the ENSO-related southerly wind anomalies were conﬁned to the south of 30 ◦ N of East Asia. After the late 1990s, by contrast, ENSO’s inﬂuence became stronger and capable of extending northward to 50 ◦ N of East Asia. The decadal strengthening of the link between ENSO and EAT is primarily modulated by the magnitudes of the ENSO-related Kuroshio anticyclone. The intensity of the Kuroshio anticyclone contributes more than 50% of the variance of the oscillational ENSO–EAT variability. Further investigation indicates that the recovered magnitude of the Kuroshio anticyclone after the late 1990s has been closely tied to the eastward shrinking of the Aleutian Low (AL) pattern, which has weakened the link of atmospheric circulation between the AL and Kuroshio Extension region. Therefore, the o ﬀ set e ﬀ ect of the AL-induced negative (positive) sea level pressure (SLP) anomalies on the El Niño (La Niña)-induced positive (negative) SLP anomalies over the Kuroshio Extension has also been weakened, which has facilitated the recovery of the signiﬁcant inﬂuence of ENSO on the EAT.
Surgical Reduction of Visceral versus Subcutaneous Fat and Effect on Features of the Metabolic Syndrome

Background Obesity results in both health and financial tolls for individuals and society. Despite the great efforts to increase awareness, the obesity epidemic continues at an alarming rate. Subcutaneous fat represents 85% of the fat mass in obese patients, while intra-abdominal fat, including both visceral and retroperitoneal adipose, represent about 15%. Both subcutaneous and visceral fat have a negative effect on individual health and promote metabolic diseases. Logic would thus suggest that adipose tissue removal by liposuction and/or visceral tissue removal could effect an improvement in metabolic diseases such as Type 2 diabetes?
Protein Evolution in Yeast Transcription Factor Subnetworks

When averaged over the full yeast protein–protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased negative selection. However, genomewide analysis of protein evolution in the subnetworks of associations involving yeast transcription factors (TFs) reveals that TF hubs do not tend to evolve significantly more slowly than TF non-hubs. This result holds for all four major types of TF hubs: interaction hubs, regulatory in-degree and outdegree hubs, as well as co-regulatory hubs that jointly regulate target genes with many TFs. Furthermore, TF regulatory in-degree hubs tend to evolve significantly more quickly than TF non-hubs. Most importantly, the correlations between evolutionary rate (KA/KS) and degrees for TFs are significantly more positive than those for generic proteins within the same global protein–protein interaction and transcriptional regulatory networks. Compared to generic protein hubs, TF hubs operate at a higher level in the hierarchical structure of cellular networks, and hence experience additional evolutionary forces (relaxed negative selection or positive selection through network rewiring). The striking difference between the evolution of TF hubs and generic protein hubs demonstrates that components within the same global network can be governed by distinct organizational and evolu-
VHRM_A_205935 317..324

Clovis Nkoke Marius Jordan Tchinde Ngueping Faustin Atemkeng Denis Teuwafeu Jerome Boombhi 4 Alain Menanga 1Buea Regional Hospital, Department of Internal Medicine, Buea, South West Region, Cameroon; 2University of Buea, Faculty of Health Sciences, Department of Medicine, Buea, South West Region, Cameroon; 3Deido District Hospital, Department of Surgery, Douala, Littoral Region, Cameroon; 4University of Yaounde I, Faculty of Medicine and Biomedical Sciences, Department of Internal Medicine, Yaounde, Center Region, Cameroon Background: Venous thromboembolism (VTE) is a serious complication in hospitalized patients. It is associated with considerable morbidity and mortality. Therefore, its prevention is of great importance. There is paucity of data on the incidence of VTE in hospitalized patients in Cameroon. The aim of this study was to determine the incidence of symptomatic VTE, its risk factors and the proportion of patients at risk that receive thromboprophylaxis in patients hospitalized in the medical and surgical units in two hospitals in the South West Region of Cameroon. Methods: A prospective study was performed in the medical and surgical units from January to March 2018. All consecutive eligible patients admitted for at least 3 days were included. Patient profile and risk factors were recorded. Patients were followed and evaluated for signs and symptoms of VTE until discharge from hospital. Suspected VTE was confirmed using compression ultrasonography and computed tomography. Results: A total of 314 patients were included of which 58.7% were females. The mean age was 46±17.9 years. Patients aged <40 years represented 42% of the study population. Three cases of symptomatic VTE were recorded. The incidence of symptomatic VTE was 1% (95% CI: 0.3–2.8%). The prevalence of VTE risk was 93.6% with 32.5% being at high risk. The risk was 94.6% in medical patients and 92.8% in surgical patients. Among the patients at risk, only 32.5% received thromboprophylaxis. Thromboprophylaxis was significantly higher in surgical patients compared to medical patients (45.2% versus 18.7%; p<0.0001). Conclusion: The incidence of VTE in hospitalized medical and surgical patients appeared low but likely underestimated considering the high prevalence of patients at risk of VTE coupled with the underutilization of thromboprophylaxis. Clinicians should assess risk of VTE in conjunction with the clinical situation to determine the most appropriate type of prophylaxis as well as the duration of prophylaxis for VTE.
Community-Based Acceleration Model of Entrepreneurship Growth and Development on Telematics Creative Industries in Malang Raya Indonesia

: The current economic era has shifted from the information economy to the creative economy. The creative industry is one of the important contributors to the economies of countries in the world. The purpose of this research is to develop community-based acceleration model of entrepreneurship growth and development on Telematics Creative Industry (TCI) in Malang Raya. This is an exploratory research. The subjects of the research are communities and actors on telematics, local government organizations, business/industry, and academics. Data collection techniques used interview, Focus Group Discussion, Direct Observation and Documentation. Research data was analyzed by using qualitative descriptive analysis, SWOT analysis, and Analytical Hierarchy Process (AHP). The research concludes that the model that can be developed to increase the role of creative industry is Quadruple Helix model with optimization of each party's role to achieve synergy. Coordination is important for each region and among stakeholders. To improve the development of entrepreneurship in the field of Telematics Creative Industry in Malang Raya needs real actions from various parties, especially in the form of training, mentoring, facilitation and assistance.
Impact of South Paciﬁc Subtropical Dipole Mode on the Equatorial Paciﬁc

Previous studies have indicated that a sea surface temperature anomaly (SSTA) dipole in the subtropical South Paciﬁc (SPSD), which peaks in austral summer (January–March), is dominated by thermodynamic processes. Observational analyses and numerical experiments were used to investigate the inﬂuence of SPSD mode on the equatorial Paciﬁc. The model is an atmospheric general circulation model coupled to a reduced-gravity ocean model. An SPSD-like SSTA was imposed on 1 March, after which the model was free to evolve until the end of the year. The coupled model response showed that warm SSTAs extend toward the equator with northwesterly wind anomalies and then grow to El Ni ñ o–like anomalies by the end of the year. SPSD forcing weakens southeasterly trade winds and propagates warm SSTAs toward the equator through wind– evaporation–SST (WES) feedback. Meanwhile, relaxation of trade winds in the eastern equatorial Paciﬁc depresses the thermocline and upwelling. Eastward anomalous currents near the equator cause warm hori- zontal advection in the central Paciﬁc. Further experiments showed that thermodynamic coupling mainly acts on but is not essential for SSTA propagation, either from the subtropics to the equator or westward along the equator, while oceanic dynamic coupling alone also appears to be able to initiate anomalies on the equator and plays a critical role in SSTA growth in the tropical Paciﬁc. This is consistent with observational analyses, which indicated that inﬂuence of WES feedback on SSTA propagation associated with the SPSD is limited. Finally, the warm pole close to the equator plays the dominant role in inducing the El Ni ñ o–like anomalies.
First Report of Brucellosis in Dairy Cattle and Humans in Military Farms in Bangladesh

Brucellosis is a great concern for the dairy farming globally including Bangladesh. It is also an important zoonosis having public health significance. The seroprevalence, risk factors and species of Brucella prevalent in Bangladesh is known in large extent but the status of this disease in military farms is unknown. This study was performed to know the seroprevalence of brucellosis in 744 lactating cattle in eight military farms and 347 in contact humans using Rose Bengal Plate Test (RBT). The overall prevalence of bovine brucellosis was 2.3% (95% Confidence Interval [CI]: 1.4 - 3.7). The seroprevalence of bovine brucellosis varied from 0 -3.6% in different farms. The overall seroprevalence of brucellosis was 0.7% (95% CI: 0.2 - 2.2) in humans in contact with military farms. The prevalence of bovine brucellosis varied in different military farm but the level is not high. The prevalence of brucellosis in accompanied humans is also very low. Further studies to identify possible factors responsible for the seroprevalence of brucellosis in humans and cattle in military farms are recommended.
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through (cid:1) 2 (cid:2) 1 integrin

ndorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits several aspects of angiogenesis. We provide evidence for a novel biological axis that links a soluble fragment of perlecan protein core to the major cell surface receptor for collagen I, (cid:1) 2 (cid:2) 1 integrin, and provide an initial investigation of the intracellular signaling events that lead to endorepellin antiangiogenic activity. The interaction between endorepellin and (cid:1) 2 (cid:2) 1 integrin triggers a unique signaling pathway that causes an increase in the second messenger cAMP; activation of two proximal kinases, protein kinase A and focal adhesion E kinase; transient activation of p38 mitogen-activated protein kinase and heat shock protein 27, followed by a rapid down-regulation of the latter two proteins; and ultimately disassembly of actin stress ﬁbers and focal adhesions. The end result is a profound block of endothelial cell migration and angiogenesis. Because perlecan is present in both endothelial and smooth muscle cell basement membranes, proteolytic activity during the initial stages of angiogenesis could liberate antiangiogenic fragments from blood vessels’ walls, including endorepellin.
Edinburgh Research Explorer Potato virus X-induced gene silencing in leaves and tubers of potato

Virus induced gene silencing (VIGS) is increasingly used to generate transient loss-of-function assays and has potential as a powerful reverse-genetics tool in functional genomic programs as a more rapid alternative to stable transformation. A previously described potato virus X (PVX) VIGS vector has been shown to trigger silencing in the permissive host Nicotiana benthamiana . This paper demonstrates that a PVX-based VIGS vector is also effective in triggering a VIGS response in both diploid and cultivated tetraploid Solanum species. We show that systemic silencing of a phytoene desaturase gene is observed and maintained throughout the foliar tissues of potato plants and was also observed in tubers. Here we report that VIGS can be triggered and sustained on in vitro micropropagated tetraploid potato for several cycles and on in vitro generated microtubers. This approach will facilitate large-scale functional analysis of potato expressed sequence tags and provide a noninvasive reverse-genetic approach to study mechanisms involved in tuber and microtuber development. completion of the Arabidopsis genome