Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural correlates with individual differences in temporal prediction during auditory-motor synchronization

Abstract Temporal prediction ability is vital for movement synchronization with external rhythmic stimuli (sensorimotor synchronization); however, little is known regarding individual variations in temporal prediction ability and its neural correlates. We determined the underlying neural correlates of temporal prediction and individual variations during auditory-motor synchronization. We hypothesized that the non-primary motor cortices, such as the premotor cortex and supplementary motor area, are the key brain regions that correlate individual variations in prediction ability. Functional magnetic resonance imaging (7T) was performed for 18 healthy volunteers who tapped to 3 types of auditory metronome beats: isochronous, tempo change, and random. The prediction ability was evaluated using prediction/tracking ratios that were computed based on cross-correlations between tap timing and pacing events. Participants with a higher prediction/tracking ratio (i.e. stronger predictive tendency) tapped to metronome beats more accurately and precisely. The prediction/tracking ratio was positively correlated with the activity in the bilateral dorsal premotor cortex (PMd), suggesting that the bilateral PMd explains the individual variation in prediction ability. These results indicate that the PMd is involved in generating a model for temporal prediction of auditory rhythm patterns and its activity would reflect model accuracy, which is critical for accurate and precise sensorimotor synchronization.
Comparison of the Toxicological Effects of Pesticides in Non-Tumorigenic MCF-12A and Tumorigenic MCF-7 Human Breast Cells

Humans are exposed to residues of organophosphate and neonicotinoid pesticides, commonly used in agriculture. Children are particularly vulnerable and, among possible adverse outcomes, the increased incidence of premature mammary gland development (thelarche) has raised concern. We evaluated the toxicological effects of chlorpyrifos (CPF), imidacloprid (IMI) and glyphosate (GLY) at exposure concentrations occurring in children on the tumorigenic MCF-7 and non-tumorigenic MCF-12A breast cell lines, as representative of the target organ model, assessing cytotoxicity, apoptosis, necrosis, intracellular reactive oxygen species (ROS) and ATP levels, 17β-estradiol secretion and gene expression of nuclear receptors involved in mammary gland development. The pesticides decreased cell vitality in MCF-7 and cell proliferation in MCF-12A cells. ATP levels were decreased in MCF-7 cells by pesticides and apoptosis was increased in MCF-12A cells only by GLY (2.3 nM). ROS production was decreased by pesticides in both cell lines, except IMI (1.6 nM) in MCF-7 cells. Endocrine disrupting activity was highlighted by induction of 17β-estradiol secretion and modulation of the gene expression of estrogen alpha and beta, progesterone, androgen, and aryl hydrocarbon receptors in both cell lines. The use of MCF-7 and MCF-12A cells highlighted dissimilar modes of action of each pesticide at low human relevant concentrations.
Hydrological behaviour of an unregulated eastern slope river under changing historical climate

Abstract The Elbow River is an eastern slope river with headwaters in the Rocky Mountains in Alberta whose major end-use is a critical source of municipal water for Calgary. Overwinter precipitation in its watershed falls primarily as snow and accumulates as snowpack until spring melt. Precipitation falls mainly as rain from May until October. The river is unregulated above Calgary’s water supply reservoir, and its relatively undeveloped watershed makes it ideal for examining potential climate change impacts on river hydrology. Available historical hydrometeorological data (1967 to 2015) from the basin were assessed to study its hydrological behaviour under a changing climate. The analysis showed significant upward trends in both flow and precipitation variables, especially from 1979 to 2015. Significant increases in both annual flow volume and annual maximum daily flow (AM-flow), and later seasonal occurrence of AM-flow, were not observed in other eastern slope rivers. Although these changes could attenuate predicted water supply shortages, they could also potentially increase flood magnitudes. The analysis also revealed that three sub-watersheds, which are approximately equal in geographic area, contributed differing flow volumes during the high-flow season (May to October). The upper watershed contributed most (∼68%), followed by the middle (∼26%) and lower (∼6%) watersheds, on average. Extreme high-flow events (ie >90th percentile AM-flow) were strongly related to high rainfall events, but not significantly related to snowpack loss (or melt). Moderate AM-flows were positively related to both the cumulative snowpack loss before the high-flow season and the cumulative antecedent precipitation prior to the AM-flow, suggesting that the antecedent soil moisture conditions could play a role. Predictions of climate change impacts on this eastern slope river’s hydrology should thus consider the effects of meteorological variables and the moisture conditions of the watershed.
Cecal duplication cyst presenting with acute abdomen: a case report

Cecal duplication cyst is a rare congenital malformation with a few reported adult cases. We present a 23-year-old man who presented with low-grade fever, constipation, and right lower quadrant pain for three days. An abdominal computed tomography scan showed a cystic mass of 8.8x7. 5x6 cm adjoining to the posterior wall of the cecum. The patient underwent abdominal laparotomy, and a right hemicolectomy was performed with resection of the duplication cyst. The histopathological study confirmed the diagnosis of a non-communicating cecal duplication cyst. In conclusion, it is essential to include cecal duplication cyst in the differential diagnosis of the acute abdomen to guarantee the best treatment strategy.
Ocular Microbiome in a Group of Clinically Healthy Horses

Simple Summary The microbiome of the ocular surface is composed of a large number of microorganisms dominated by bacteria and is poorly described in horses compared to other species, including humans. The objective of this study was to characterize and predict the abundance of metabolic genes of the ocular microbiome of a group of clinically healthy horses. Conjunctival swabs were obtained from both eyes of 14 horses, and DNA extraction was performed from the swabs, followed by next generation sequencing and bioinformatics analyses. The most abundant phylum was Pseudomonadota (Proteobacteria), followed by Actinomycetota (Actinobacteria) and Bacteroidota (Bacteroidetes). A total of 278 genera were identified, such as Massilia, Pedobacter, Pseudomonas, Sphingomonas, Suttonella and Verticia, among others. The inference of metabolic functions indicates that the microorganisms present in the ocular conjunctiva perform functions that point to cell growth and metabolism. Abstract The ocular microbiome in horses is poorly described compared to other species, and most of the information available in the literature is based on traditional techniques, which has limited the depth of the knowledge on the subject. The objective of this study was to characterize and predict the metabolic pathways of the ocular microbiome of a group of healthy horses. Conjunctival swabs were obtained from both eyes of 14 horses, and DNA extraction was performed from the swabs, followed by next generation sequencing and bioinformatics analyses employing DADA2 and PICRUSt2. A total of 17 phyla were identified, of which Pseudomonadota (Proteobacteria) was the most abundant (59.88%), followed by Actinomycetota (Actinobacteria) (22.44%) and Bacteroidota (Bacteroidetes) (16.39%), totaling an average of 98.72% of the communities. Similarly, of the 278 genera identified, Massilia, Pedobacter, Pseudomonas, Sphingomonas, Suttonella and Verticia were present in more than 5% of the samples analyzed. Both Actinobacteria and Bacteroides showed great heterogeneity within the samples. The most abundant inferred metabolic functions were related to vital functions for bacteria such as aerobic respiration, amino acid, and lipid biosynthesis.
Flexural Strength of CAD/CAM Denture Base Materials: Systematic Review and Meta-analysis of In-vitro Studies

Introduction: Digital complete dentures fabrication techniques are expanding. This study aimed to review flexural strength (FS) of milled and 3D-printed denture base materials to answer the study question: is FS of computer-aided designing/computer-aided manufacturing (CAD/CAM) denture base comparable to conventional heat-polymerized materials? Materials and Methods: Search was done within different databases for articles published between January 2010 and June 2021 using specific keywords. Articles of in-vitro studies in English language with methods following International Standards Organization standardization/ADA specifications for flexural testing of conventional and CAD/CAM (milled or printed) polymethyl methacrylate (PMMA) materials were included. Results: Out of the 61 studies, 9 were processed for data extraction and only 7 underwent meta-analysis. Two, six, and one study showed high, moderate, and low risk of bias, respectively. Random-effects model was used for analysis and resulted in the average FS of 120.61 MPa [95% confidence interval (CI): 109.81−131.41] and 92.16 MPa (CI: 75.12−109.19) for CAD/CAM milled and heat-polymerized PMMA, respectively. Conclusion: Subtractive CAD/CAM technique of denture fabrication showed satisfactory FS values, whereas additive CAD/CAM method was comparable to conventional heat-polymerized technique with lower value, requiring further investigations and improvement. The clinical use of milled denture bases is an acceptable substitution to heat-polymerized PMMA, making the denture fabrication an easier and faster process.
Building Exoskeletons for the Integrated Retrofit of Social Housing

In Europe, most of the social housing heritage, built before the 1980s, suffers of architectural and functional obsolescence and seismic vulnerability, raising questions about the future of the cities and their inhabitants. In an era of environmental emergency and lack of resources demolition and reconstruction is not a sustainable alternative. A multi-purpose campaign of architectural, functional and structural retrofit is fundamental but the complex information and requirements to handle require integrated and innovative solutions. The bio-mimicry design approach led to the definition of the “building exoskeleton”: an external steel frame, two or three-dimensional, encapsulating the existing building and provided of shape memory alloys-based devices for passive seismic dissipation. The simplicity of the structure gives high flexibility in the definition of the new architectural features and functional performances, adapting to the changing necessities on both space and time scales. The energy performances result also radically improved. The efficiency of this scheme to improve the seismic response of the constructions is verified for a real case study – a concrete frame with brick infill – through static and dynamic nonlinear analyses with the software SAP2000. Finally, the economic and technical feasibility of the proposal is discussed together with the implications of the project and the possible developments.
Bandstop Frequency Selective Surfaces Based on Aramid Paper Honeycomb Structure

Novel designs of paper-based bandstop frequency selective surfaces (FSSs) are presented in this paper. The characteristics of the paper-based honeycomb structure are investigated first. One folded dipole resonator with first-order bandstop response is analyzed and further printed on the side walls of the honeycomb structure accordingly. A second-order response with two cascade FSSs is proposed with controllable bandwidth by the coupling coefficient of the resonators with the aid of the equivalent circuit model. Two paper-based FSS samples were fabricated and measured to demonstrate the validity of the proposed design strategies. Benefiting from the merits of lightweight and strong mechanical properties, the proposed paper-based FSS is a potential candidate for application in radar systems and aircraft.
Photocuring Temperature Study for Curl Distortion Control in Projection-Based Stereolithography

Polymerization shrinkage and thermal cooling effect have been identified as two major factors that lead to the curl distortion in the stereolithography apparatus (SLA) process. In this paper, the photocuring temperature during the building process of mask image projection-based stereolithography (MIP-SL) and how it affects parts’ curl distortion are investigated using a high-resolution infrared (IR) camera. Test cases of photocuring layers with different shapes, sizes, and layer thicknesses have been designed and tested. The experimental results reveal that the temperature increase of a cured layer is mainly related to the layer thickness, while the layer shapes and sizes have little effect. The photocuring temperatures of built layers using different exposure strategies including varying exposure time, grayscale levels, and mask image patterns have been studied. The curl distortions of a test case based on various exposure strategies have been measured and analyzed. It is shown that, by decreasing the photocuring temperature of built layers, the exposure strategies using grayscale levels and mask image patterns can effectively reduce the curl distortion with the expense of increased building time. In addition to curl distortion control, the photocuring temperature study also provides a basis for the curl distortion simulation in the MIP-SL process. [DOI: 10.1115/1.4034305]
Parallel-Disk Viscometry of a Viscoplastic Hydrogel: Yield Stress and Other Parameters of Shear Viscosity and Wall Slip

The rheology, i.e., the flow and deformation properties, of hydrogels is generally a very important consideration for their functionality. However, the accurate characterization of their rheological material functions is handicapped by their ubiquitous viscoplasticity and associated wall slip behavior. Here a parallel-disk viscometer was used to characterize the shear viscosity and wall slip behavior of a crosslinked poly(acrylic acid) (PAA) carbomer hydrogel (specifically Carbopol® at 0.12% by weight in water). It was demonstrated that parallel-disk viscometry, i.e., the steady torsional flow in between two parallel disks, can be used to unambiguously determine the yield stress and other parameters of viscoplastic constitutive equations and wall slip behavior. It was specifically shown that torque versus rotational speed information, obtained from parallel-disk viscometry, was sufficient to determine the yield stress of a viscoplastic hydrogel. Additional gap-dependent data from parallel-disk viscometry could then be used to characterize the other parameters of the shear viscosity and wall slip behavior of the hydrogel. To investigate the accuracy of the parameters of shear viscosity and apparent wall slip that were determined, the data were used to calculate the torque values and the velocity distributions (using the lubrication assumption and parallel plate analogy) under different flow conditions. The calculated torques and velocity distributions of the hydrogel agreed very well with experimental data collected by Medina-Bañuelos et al., 2021, suggesting that the methodologies demonstrated here provide the means necessary to understand in detail the steady flow and deformation behavior of hydrogels. Such a detailed understanding of the viscoplastic nature and wall slip behavior of hydrogels can then be used to design and develop novel hydrogels with a wider range of applications in the medical and other industrial areas, and for finding optimum conditions for their processing and manufacturing.
Intra-guild spatial niche overlap among three small falcon species in an area of recent sympatry

Abstract Climate warming and land-use change are reshuffling the distribution of wild organisms on a global scale. Some species may expand their ranges and colonize new regions, which may greatly affect ecological interactions among pre-existing species and colonizers. In the last decades, such processes have originated a unique condition of sympatry among three Eurasian small Falco species (common kestrel F. tinnunculus, lesser kestrel F. naumanni, red-footed falcon F. vespertinus) in the intensively cultivated farmland habitats of the Po Plain (Northern Italy). This provides an excellent opportunity to investigate patterns of spatial niche overlap during the initial phases of the establishment of sympatry. To investigate spatial niche overlap of the three falcon species, we relied on Environmental Niche Models (ENMs) based on widespread breeding occurrence data obtained through field surveys and citizen science programs (during the 2018–2020 period). ENMs were based on bioclimatic and land-use variables in an ensemble modelling framework. We estimated species-specific relative contributions of each climatic and land-use variable and its response curves effect. Eventually, we generated spatial correlation maps of the potential species’ distributions to derive spatially-explicit predictions of potential co-occurrence areas among the three species. Overall, eco-climatic determinants of the distribution of lesser kestrel and red-footed falcon were similar, resulting in a strong association with intensive arable lands and dry continental climate. Consistently, we found a high spatial correlation between the suitability maps of the two species, with highly suitable areas located in the Central-Eastern area of the Po Plain, corresponding to the core range of both species. Conversely, the common kestrel emerged as a habitat generalist and was widely distributed throughout the Po Plain. Our findings suggest that the recent sympatry between lesser kestrels and red-footed falcons in the Po Plain may promote ecological interactions and intra-guild competition.
Equilibrium Effects of Pharmaceutical Bundling: Evidence from India

We study the equilibrium effects of competitive bundling on market outcomes and social welfare in the context of the Indian pharmaceutical industry. Fixed-dose combinations (FDCs), which bundle two or more drugs in a single pill, account for over 50% of pharmaceutical revenue in India. Using an equilibrium model of drug demand and supply, we show that the price and welfare effects of FDCs are theoretically ambiguous. Empirically, we find that FDCs on average sell at a 28% discount but increase standalone component prices by 3%. New FDCs significantly increase sales of drug bundles. To quantify the welfare effects of FDCs, we estimate the model in the market for Alzheimer’s drugs. We find that FDCs increase consumer surplus by 21% and firm profits by 13% because of significant market expansion and cost savings. Counterfactual analysis shows that applying FDC regulations from the US to India could deter FDC entry and forestall potential welfare benefits. welfare effects of FDCs and FDC regulations. We find that FDCs in this market increase consumer surplus by 21% and producer surplus by 13%. We also show that the cost of complying with FDC regulations, such as clinical trial requirements, may deter FDC entries and forestall their welfare benefits. These results highlight a potentially important but so far overlooked consideration in the design of FDC regulations. While our
Aerostructural Performance of Distributed Compliance Morphing Wings: Wind Tunnel and Flight Testing

The aerodynamic and structural performance of a morphing wing concept, based on fully compliant structures and actuated by closed-loop controlled solid state piezoelectric actuators, is investigated numerically and experimentally. The morphing wings are designed for a 1.75-m-span unmanned aerial vehicle operating at up to 30 m/s, following lightweight aeronautical construction principles. The goal of providing roll controllability exclusively through morphing is achieved with a concurrent aerostructural optimization, considering static and dynamic aeroelastic effects. The aeroelastic response of the wings is experimentally assessed through wind tunnel tests, performed at different speeds, angles of attack, and actuation levels. The test campaign confirms the ability to achieve lift and rolling moment variations while maintaining a high aerodynamic efficiency, and the results closely match the numerical predictions. An 8-min flight test is performed by replacing the unmanned aerial vehicle wings with the .
U.S. GAAP or IFRS - A Review of Literature

Purpose: This paper purpose is to report the differences between U.S. GAAP and IFRS by presenting a review of literature available on the topic. Methodology: This paper is based on review of 27 research papers. This paper is divided into two parts. First part presents the previous studies focused on business aspects (companies can ill afford the cost of an increasing number of GAAP standards and impact on investors) and second part presents the previous studies focused on fundamental differences between U.S. GAAP and IFRS. Findings: This paper is based on review of literature that present the differences between U.S. GAAP and International Financial Reporting Standards (IFRS). As per the studies done, U.S. GAAP contains more detailed, specific requirements than IFRS. In some instances, IFRS does not contain any corresponding guidance and, in others, IFRS contains higher-level or general guidance that is not directly comparable to the U.S. GAAP requirement. Originality/Value: This paper findings are based on 27 research papers only. As accounting standards are changing due to change in current economic situations, there is a large scope for the future studies based on U.S. GAAP and IFRS differences and impact of those difference on the investors.
Confirmatory Factor Analysis of Comorbidity between Depression and Aggression in a Child-Adolescent Community Sample: Nosological, Prognosis and Etiological Implications

Comorbidity between depression and aggression in the child-adolescent population remains a controversial phenomenon. To our knowledge, no longitudinal study using structural equation modeling (SEM) has confirmed whether the relationship between depression and aggression is due to the fact that they share internalizing and externalizing supraordinal factors at the level of the syndrome or is due to the fact that they share common characteristics in relation to an underlying factor at the level of symptoms. We examined longitudinal comorbid relationships in a community sample (N = 251) at three waves ages from 10 to 13 years. The SEM showed that longitudinally, the comorbidity between depression and aggression is due to the fact that they share characteristics of the same underlying factor at the symptom level. These results have implications for the classification, diagnosis, and treatment of comorbidity between depression and aggression in a child-adolescent population.