Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional outcome of different treatment methods in fingertip injuries: A prospective study

Background: Various treatment modalities are used from the past to treat fingertip injuries. The common methods used are suturing, skin grafting, flap coverage of the wound by different techniques. This study reports the outcome of different treatment methods used in management of fingertip injuries. Material and Methods: In a prospective study from 15 August 2006 to 31 March 2008 we included 103 patients out of which 10 patient lost in follow-up. Average age of distribution is 39.6 yrs. Patients are divided in to four treatment groups and were followed for 6 months. Assesment of results were done on basis of tip tenderness, Colour of tip with surrounding tissue, stiffness in DIP joint, sensation, aesthetic look. Results: In our series we found that a total of seventy four patients had good and excellent relief of tip tenderness after 6 month of having the definitive surgery done, a total of sixty nine patients had good and excellent result as far as tip sensation is concerned, of sixty nine patients had good and excellent result as far as tip sensation is concerned, of sixty seven patients had good and excellent result as far as cosmesis is concern after 6 month post operatively. Conclusion: Conservative management was more successful in paediatric age group than in adult age group. Maximum relief in tip tenderness, Sensation found in homodigital /local flap group. Best result of cosmesis was in grafting group and worst in distant flap group. Thenar flap was useful in middle and index finger.
Serum Oxytocin Levels and Logical Memory in Older People in Rural Japan

Objective: The present study aimed to investigate the relationship between serum oxytocin (OT) and logical memory among older people in rural Japan. Methods: This was a cross-sectional study using a survey conducted from October 2009 through March 2011. Most of the study was conducted as part of a national prevalence survey of dementia in Japan. The final sample comprised 385 community-dwelling people aged 65 years or older living in rural Japan. The mean age and standard deviation were 75.7 ± 6.76 years (144 men, mean age 75.0 ± 6.48 years; 241 women, mean age 76.2 ± 6.91 years). The participants underwent screening examinations for a prevalence survey of dementia. The screening examinations were the Mini-Mental State Examination, Clinical Dementia Rating, and “logical memory A” from the Wechsler Memory Scale–Revised (WMSR). We used the WMSR Logical Memory II delayed recall score (LM II-DR) to assess logical memory. Levels of serum OT were obtained using the enzyme immunoassay method. Results: Serum OT levels were significantly higher among women than men. The present study revealed that serum OT levels were positively associated with LM II-DR in older women living in rural Japan in multiple linear regression analyses. Conclusions: The present results suggested a positive correlation between OT and logical memory in older women living in rural Japan.
A literature Review on physiotherapeutic interventions for airway clearance in COPD patients

Chronic obstructive pulmonary disease (COPD) is internationally preferred term encompassing chronic bronchitis, asthma and emphysema. Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction with breathing-related symptoms such as chronic cough, exertional dyspnea, expectoration, and wheeze. These symptoms may occur in conjunction with airway hyper responsiveness and may be partially reversible. Obstructive lung disease includes Chronic bronchitis, Emphysema, Asthma, Bronchiectasis and Cystic fibrosis. The result of the present narrative review concluded the effectiveness of Active cycle of breathing technique, Diaphragmatic breathing exercise along with Postural drainage in Chronic Obstructive lung disease in order to achieve the significant improvement and hasten the recovery of the patients.
Association between dietary total antioxidant capacity and breast cancer: a case–control study in a Middle Eastern country

Abstract Objective: The aim of this study was to determine the relationship between dietary total antioxidant capacity (dTAC) and risk of breast cancer among Iranian women. Design: In this hospital-based case–control study, dietary intake of participants was collected using a 168-item validated FFQ. Dietary TAC was assessed using FRAP assay considering. Logistic regression was used to obtain ORs for breast cancer across quartiles of dTAC. Setting: Cancer Institute, Iran. Participants: We included 412 women with pathologically confirmed breast cancer and 456 apparently healthy controls. Results: Mean dTAC was 11·3 ± 5·8 for cases and 12·1 ± 7·9 for controls. A trend towards significant inverse association was seen between dTAC and odds of breast cancer in the whole population; such that after controlling for several potential confounders, individuals in the highest quartile of dTAC were 0·39 times less likely to have breast cancer than those in the lowest quartile (0·61; 95 % CI: 0·38, 0·99, P < 0·05). In the stratified analysis by menopausal status, we found that postmenopausal women with the greatest dTAC had lower odds for breast cancer, compared with those with the lowest dTAC (0·47; 95 % CI: 0·24, 0·93, P < 0·05). This association strengthened after additional adjustment for BMI (0·28; 95 % CI: 0·11, 0·72, P < 0·05). No significant association was seen between dTAC and odds of breast cancer in premenopausal women. Conclusions: We found that dietary TAC was inversely associated with risk of breast cancer, in particular among postmenopausal women. Prospective cohort studies are needed to confirm these findings.
Composite Films of CsPbBr3 Perovskite Nanocrystals in Hydrophobic Fluoropolymer for Temperature Imaging in Digital Microfluidics.

A composite film material which combines CsPbBr3 perovskite nanocrystals with Hyflon AD 60 fluoropolymer was developed and utilized for high resolution optical temperature imaging. It exhibited bright luminescence and, most importantly, long-term stability in aqueous medium. CsPbBr3 nanocrystal-Hyflon films immersed in aqueous solutions showed a stable luminescence over at least 4 months and exhibited a fully reversible pronounced temperature sensitivity of 1.2% K-1 between 20 and 80 ºC. They were incorporated into a digital microfluidic (electrowetting on dielectric) platform and were used for spatially-resolved temperature measurements during droplet movements. Thermal mapping with a CsPbBr3 nanocrystal-Hyflon sensing layer in a room temperature environment (22.0 °C) revealed an increase in local temperatures of up to 40.2 °C upon voltage-driven droplet manipulations in a digital microfluidic system, corresponding to a local temperature change of up to 18.2 °C.
Assessment of safety culture in organ donation.

OBJECTIVES To evaluate the perception of safety culture by health professionals who work with organ and tissue donation. METHODS A quantitative, descriptive study developed with 185 health professionals who act directly and indirectly with organ and tissue donation from two hospitals in the South of Brazil. The data collection was performed between January and July 2017 by using the Safety Attitudes Questionnaire. The analysis took place through descriptive statistics. RESULTS The mean score of the domains evaluated ranged from 41.6, for Perception of management of the unit, and 80.9 for Job satisfaction. Positive perception of safety culture in this study was evidenced only for Job satisfaction with a score higher than 75. CONCLUSIONS Of the six domains evaluated, only one had a positive score, evidencing the need to elaborate effective strategies for implanting safety culture in these institutions.
Adherence to and Retention in Medications for Opioid Use Disorder among Adolescents and Young Adults.

The volatile opioid epidemic is associated with higher levels of opioid use disorder (OUD) and negative health outcomes in adolescents and young adults. Medications for opioid use disorder (MOUD) demonstrate the best evidence for treating OUD. Adherence to and retention in MOUD among adolescents and young adults, however, is incompletely understood. This systematic review examines the state of the literature regarding the association of age with adherence to and retention in MOUD using methadone, buprenorphine, or naltrexone among persons aged 10 to 24 along with related facilitators and barriers. The research team searched for all studies of MOUD that examined adherence, retention, or related concepts as an outcome variable where the sample included adolescents or young adults. Search criteria generated 10,229 records, which, after removing duplicates and conducting title/abstract screening, yielded 587 studies for full-text review. Ultimately, 52 articles met inclusion criteria for abstraction and 17 were selected for qualitative coding and analysis. This review found younger age to be consistently associated with shorter retention in the published literature, although the overall quality of included studies was low. Several factors at the individual, interpersonal, and institutional levels, such as concurrent substance use, MOUD adherence, family conflict, and MOUD dosage and flexibility, were seen as playing a role in MOUD retention among adolescents and young adults. This review highlights how MOUD providers can tailor treatment to increase retention of adolescents and young adults while pointing to the need for more research explaining MOUD adherence and retention disparities in this age group.
Plasma Biomarkers of Tubular Injury and Inflammation Are Associated with Chronic Kidney Disease Progression in Children.

BACKGROUND After accounting for known risk factors for CKD progression in children, clinical outcomes among children with CKD still vary substantially. Biomarkers of tubular injury (such as KIM-1), repair (such as YKL-40), or inflammation (such as MCP-1, suPAR, TNF receptor-1 [TNFR-1], and TNFR-2) may identify children with CKD at risk for GFR decline. METHODS We investigated whether plasma KIM-1, YKL-40, MCP-1, suPAR, TNFR-1, and TNFR-2 are associated with GFR decline in children with CKD and in subgroups defined by glomerular versus nonglomerular cause of CKD. We studied participants of the prospective CKiD Cohort Study which enrolled children with an eGFR of 30-90 ml/min per 1.73 m2 and then assessed eGFR annually. Biomarkers were measured in plasma collected 5 months after study enrollment. The primary endpoint was CKD progression, defined as a composite of a 50% decline in eGFR or incident ESKD. RESULTS Of the 651 children evaluated (median age 11 years; median baseline eGFR of 53 ml/min per 1.73 m2), 195 (30%) had a glomerular cause of CKD. Over a median follow-up of 5.7 years, 223 children (34%) experienced CKD progression to the composite endpoint. After multivariable adjustment, children with a plasma KIM-1, TNFR-1, or TNFR-2 concentration in the highest quartile were at significantly higher risk of CKD progression compared with children with a concentration for the respective biomarker in the lowest quartile (a 4-fold higher risk for KIM-1 and TNFR-1 and a 2-fold higher risk for TNFR-2). Plasma MCP-1, suPAR, and YKL-40 were not independently associated with progression. When stratified by glomerular versus nonglomerular etiology of CKD, effect estimates did not differ significantly. CONCLUSIONS Higher plasma KIM-1, TNFR-1, and TNFR-2 are independently associated with CKD progression in children.
Real life experience of apremilast in psoriasis and arthritis psoriatic patients: Preliminary results on metabolic biomarkers

Psoriasis is a common inflammatory skin condition, affecting 2–4% of the worldwide population. Psoriasis remains an important public health challenge because there are many clinical forms of psoriasis in particular sites, probably related to the dysregulation of different cytokines. Therefore, there is a continuous need to improve treatment options with mechanisms of action different from those of the currently known therapies. Advances in knowledge of the molecular bases of pathogenesis lead to a better understanding of the disease, thus influencing the development and management of effective treatments. Moreover, data from recent published work indicate that psoriasis coexists with cardiovascular diseases, metabolic syndrome, diabetes mellitus and psychiatric disorders. We present results from our 52‐week open‐label trial in a cohort of psoriatic and psoriatic arthritis patients treated with daily p.o. doses of apremilast 60 mg. We confirmed the efficacy and safety of the drug in favoring the improvement of skin and joint disease as well as the modulation of metabolic biomarkers in diabetic and non‐diabetic psoriatic patients. Apremilast could be used successfully in psoriatic patients affected by cardiometabolic comorbidities, ensuring an improvement in both diseases.
Constructing Semantic Models From Words, Images, and Emojis

A number of recent models of semantics combine linguistic information, derived from text corpora, and visual information, derived from image collections, demonstrating that the resulting multimodal models are better than either of their unimodal counterparts, in accounting for behavioral data. Empirical work on semantic processing has shown that emotion also plays an important role especially in abstract concepts; however, models integrating emotion along with linguistic and visual information are lacking. Here, we first improve on visual and affective representations, derived from state-of-the-art existing models, by choosing models that best fit available human semantic data and extending the number of concepts they cover. Crucially then, we assess whether adding affective representations (obtained from a neural network model designed to predict emojis from co-occurring text) improves the model's ability to fit semantic similarity/relatedness judgments from a purely linguistic and linguistic-visual model. We find that, given specific weights assigned to the models, adding both visual and affective representations improves performance, with visual representations providing an improvement especially for more concrete words, and affective representations improving especially the fit for more abstract words.
Characterization, Pathogenesis, and Clinical Implications of Inflammation‐Related Atrial Myopathy as an Important Cause of Atrial Fibrillation

Abstract Historically, atrial fibrillation has been observed in clinical settings of prolonged hemodynamic stress, eg, hypertension and valvular heart disease. However, recently, the most prominent precedents to atrial fibrillation are metabolic diseases that are associated with adipose tissue inflammation (ie, obesity and diabetes mellitus) and systemic inflammatory disorders (ie, rheumatoid arthritis and psoriasis). These patients typically have little evidence of left ventricular hypertrophy or dilatation; instead, imaging reveals abnormalities of the structure or function of the atria, particularly the left atrium, indicative of an atrial myopathy. The left atrium is enlarged, fibrotic and noncompliant, potentially because the predisposing disorder leads to an expansion of epicardial adipose tissue, which transmits proinflammatory mediators to the underlying left atrium. The development of an atrial myopathy not only leads to atrial fibrillation, but also contributes to pulmonary venous hypertension and systemic thromboembolism. These mechanisms explain why disorders of systemic or adipose tissue inflammation are accompanied an increased risk of atrial fibrillation, abnormalities of left atrium geometry and an enhanced risk of stroke. The risk of stroke exceeds that predicted by conventional cardiovascular risk factors or thromboembolism risk scores used to guide the use of anticoagulation, but it is strongly linked to clinical evidence and biomarkers of systemic inflammation.
Monitoring of group mates in relation to their behavior in mandrills

Primates are known to have considerable knowledge about the social relationships that link their group mates and are likely to derive this information from observing the social interactions that occur in their social group. They may, therefore, be hypothesized to pay particular attention to the social interactions involving group mates. In this study, we evaluated how the attention captive mandrills (Mandrillus sphinx) devote to their group mates was modulated by the behavior of the latter. Mandrills looked most frequently at foraging individuals and least frequently at sleeping individuals. Mandrills also looked at grooming individuals more than at individuals that were simply sitting in contact. Grooming dyads were looked at regardless of the social rank and kinship of the individuals involved. These results contribute to our understanding of how primates obtain their social knowledge.
Geometric description for the anatomy of the mitral valve: A review

The mitral valve is a complex anatomical structure whose physiological functioning relies on the biomechanical properties and structural integrity of its components. Their compromise can lead to mitral valve dysfunction, associated with morbidity and mortality. Therefore, a review on the morphometry of the mitral valve is crucial, more specifically on the importance of valve dimensions and shape for its function. This review initially provides a brief background on the anatomy and physiology of the mitral valve, followed by an analysis of the morphological information available. A characterisation of mathematical descriptions of several parts of the valve is performed and the impact of different dimensions and shape changes in disease is then outlined. Finally, a section regarding future directions and recommendations for the use of morphometric information in clinical analysis of the mitral valve is presented.
Target Recognition in Infrared Circumferential Scanning System via Deep Convolutional Neural Networks

With an infrared circumferential scanning system (IRCSS), we can realize long-time surveillance over a large field of view. Recognizing targets in the field of view automatically is a crucial component of improving environmental awareness under the trend of informatization, especially in the defense system. Target recognition consists of two subtasks: detection and identification, corresponding to the position and category of the target, respectively. In this study, we propose a deep convolutional neural network (DCNN)-based method to realize the end-to-end target recognition in the IRCSS. Existing DCNN-based methods require a large annotated dataset for training, while public infrared datasets are mostly used for target tracking. Therefore, we build an infrared target recognition dataset to both overcome the shortage of data and enhance the adaptability of the algorithm in various scenes. We then use data augmentation and exploit the optimal cross-domain transfer learning strategy for network training. In this process, we design the smoother L1 as the loss function in bounding box regression for better localization performance. In the experiments, the proposed method achieved 82.7 mAP, accomplishing the end-to-end infrared target recognition with high effectiveness on accuracy.
X‐ray crystal structure localizes the mechanism of inhibition of an IL‐36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains

Cellular signaling via binding of the cytokines IL‐36α, β, and γ along with binding of the accessory protein IL‐36RAcP, to their cognate receptor IL‐36R is believed to play a major role in epithelial and immune cell‐mediated inflammation responses. Antagonizing the signaling cascade that results from these binding events via a directed monoclonal antibody provides an opportunity to suppress such immune responses. We report here the molecular structure of a complex between an extracellular portion of human IL‐36R and a Fab derived from a high affinity anti‐IL‐36R neutralizing monoclonal antibody at 2.3 Å resolution. This structure, the first of IL‐36R, reveals similarities with other structurally characterized IL‐1R family members and elucidates the molecular determinants leading to the high affinity binding of the monoclonal antibody. The structure of the complex reveals that the epitope recognized by the Fab is remote from both the putative ligand and accessory protein binding interfaces on IL‐36R, suggesting that the functional activity of the antibody is noncompetitive for these binding events.
The study of serum c-reactive protein and its diagnostic importance in reducing the rate of negative appendectomy

Background: Introduction-Acute appendicitis is the most common abdominal surgical emergency and appendectomy is one of the most frequently performed abdominal operation but the diagnosis of acute appendicitis remains an enigmatic challenge, plagued by high rate of negative exploration. The objective of this study was to assess the accuracy of CRP over TLC in the diagnosis of acute appendicitis. Methods: Total 200 patients who had been diagnosed as a case of acute appendicitis based on WBC count and clinical diagnosis and were planned for appendectomy were selected for purposive sampling. Serum CRP was estimated in these patients before operation but was not considered in decision making process of appendectomy. All 200 removed appendixes were sent for histopathological examination. Results: Result-Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of serum CRP were much greater than WBC count. Mean and standard deviation of serum CRP was 41.92±26.28 with p=<0.0001 which is highly significant. Conclusions: Conclusion-CRP should be added along with clinical diagnosis and other laboratory test in diagnosis of acute appendicitis to reduce the rate of negative appendectomy.
Increased calcium-mediated cerebral processes after peripheral injury: possible role of the brain in complex regional pain syndrome

Background Among various diseases that accompany pain, complex regional pain syndrome (CRPS) is one of the most frustrating for patients and physicians. Recently, many studies have shown functional and anatomical abnormalities in the brains of patients with CRPS. The calcium-related signaling pathway is important in various physiologic processes via calmodulin (CaM) and calcium-calmodulin kinase 2 (CaMK2). To investigate the cerebral mechanism of CRPS, we measured changes in CaM and CaMK2 expression in the cerebrum in CRPS animal models. Methods The chronic post-ischemia pain model was employed for CRPS model generation. After generation of the animal models, the animals were categorized into three groups based on changes in the withdrawal threshold for the affected limb: CRPS-positive (P), CRPS-negative (N), and control (C) groups. Western blot analysis was performed to measure CaM and CaMK2 expression in the rat cerebrum. Results Animals with a decreased withdrawal threshold (group P) showed a significant increment in cerebral CaM and CaMK2 expression (P = 0.013 and P = 0.021, respectively). However, groups N and C showed no difference in CaM and CaMK2 expression. Conclusions The calcium-mediated cerebral process occurs after peripheral injury in CRPS, and there can be a relationship between the cerebrum and the pathogenesis of CRPS.