Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility and Safety of Anlotinib Monotherapy for Patients with Previously Treated Advanced Esophageal Squamous Cell Carcinoma: A Real-World Exploratory Study

Objective This study was to investigate the feasibility and safety of anlotinib monotherapy for patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC) retrospectively. Methods This study was designed as a real-world study. A total of 83 patients with advanced or metastatic ESCC who received anlotinib monotherapy were included. Demographic characteristics of the patients, efficacy data of the treatment and adverse reactions during the treatment were documented and analyzed through the electronic medical record system in the hospital. All the patients were followed up regularly. The primary endpoint of this study was progression-free survival (PFS), secondary endpoints were objective response rate (ORR), disease control rate (DCR), overall survival (OS), safety profile and PFS analysis according to adverse reactions. Results A total of 83 patients with ESCC who received anlotinib monotherapy were included. Partial response was observed in 7 patients, stable disease was noted in 51 patients and progressive disease was found in 25 patients, which yielded an ORR of 8.4% (95% CI: 3.5–16.6%), and a DCR of 69.9% (95% CI: 58.8–79.5%). Furthermore, the median PFS of the 83 patients with advanced ESCC was 3.3 months (95% CI: 2.20–4.40) and the median OS was 7.8 months (95% CI: 5.40–10.20). Common adverse reactions among the 83 patients were hypertension (51.8%), fatigue (48.2%), weight loss (41.0%), diarrhea (34.9) and hand-foot syndrome (30.1%). Correlation analysis between hypertension status and PFS suggested that PFS of the patients with hypertension was longer than that of those with non-hypertension (median PFS: 4.5 vs 3.0 months, P = 0.019). Conclusion Anlotinib monotherapy demonstrated promising efficacy and tolerable toxicity for patients with previously treated advanced or metastatic ESCC. Hypertension that occurs during anlotinib administration might be used as a potential biomarker to predict PFS of patients with ESCC. The conclusion should be confirmed in prospective clinical trials subsequently.
INVESTIGATING THE COMPARATIVE EFFECTS OF SUSTAINED SILENT READING, ASSISTED REPEATED READING, AND TRADITIONAL READING

This quasi-experimental study aims to investigate the effects of Sustained Silent Reading (SSR), Assisted Repeated Reading (ARR), and Traditional Reading (TR) instructions integrated into an EFL reading program on EFL reading comprehension, silent reading rate, reading motivation, and attitudes toward EFL reading, by also addressing the potential effect of proficiency level. Adopting a mixed-method pretest-posttest research design, this 10-week study was conducted with mixed-proficiency university-level Turkish EFL learners divided into three experimental groups. A method incorporating 150-minute SSR or ARR instructions into the 150-minute intensive reading instruction in two groups was implemented, as compared against a TR group that received 300-minute traditional intensive reading instruction weekly. Data came from a reading comprehension and rate test, reading motivation questionnaire, participant reflections, and interviews. Findings indicated that SSR yielded significant benefits for reading comprehension of both low and high-proficiency participants. Moreover, SSR and ARR showed positive effects on intrinsic reading motivation, whereas TR contributed slightly to extrinsic reading motivation. Regarding the possible effect of proficiency, while SSR yielded more advantages for higher-proficiency learners, ARR and TR were comparatively more beneficial for lower-proficiency learners. Implications for pedagogy and future research for university-level EFL reading classes are discussed.
Food restriction protects the myenteric nervous population of rats with type 2 diabetes mellitus

Background: Type 2 diabetes affects the intestine. Food restriction (FR) promotes benefits, but the studies of its effects in rats are scarce. This study aims to analyze the influence of two type 2 diabetes models and FR over the intestine morphology. Methods: Thirty Wistar rats formed three groups (n=10/group) treated for two months: C (control); DE (diabetic with streptozotocin+cafeteria-style diet); and DN (diabetic with streptozotocin+nicotinamide). These groups were subdivided into six during two months: CC (control), CCR (control+food restriction), DEC (diabetic+standard diet), DER (diabetic+food restriction), DNC (diabetic+standard diet) and DNR (diabetic+food restriction). FR was 50% of the average daily dietary intake of group C. Jejunum and ileum samples were collected for evaluation of wall morphometry, goblet cell number, number and profile of myenteric neurons and glia. Results: The DE model promoted wall reduction in both segments, while DN jejunum was increased. Goblet cells were reduced in the jejunum for both diabetic models and FR. Both intestinal segments presented reduction of neuronal and glial myenteric populations in diabetes. Conclusions: FR promoted protection of myenteric neurons and glial cells against diabetic damage. The jejunum and ileum respond differently to diabetes and FR. FR has positive effects over the small intestine, mainly over the enteric nervous system.
Using Artificial Intelligence as a Diagnostic Decision Support Tool in Skin Disease: Protocol for an Observational Prospective Cohort Study

Background Dermatological conditions are a relevant health problem. Each person has an average of 1.6 skin diseases per year, and consultations for skin pathology represent 20% of the total annual visits to primary care and around 35% are referred to a dermatology specialist. Machine learning (ML) models can be a good tool to help primary care professionals, as it can analyze and optimize complex sets of data. In addition, ML models are increasingly being applied to dermatology as a diagnostic decision support tool using image analysis, especially for skin cancer detection and classification. Objective This study aims to perform a prospective validation of an image analysis ML model as a diagnostic decision support tool for the diagnosis of dermatological conditions. Methods In this prospective study, 100 consecutive patients who visit a participant general practitioner (GP) with a skin problem in central Catalonia were recruited. Data collection was planned to last 7 months. Anonymized pictures of skin diseases were taken and introduced to the ML model interface (capable of screening for 44 different skin diseases), which returned the top 5 diagnoses by probability. The same image was also sent as a teledermatology consultation following the current stablished workflow. The GP, ML model, and dermatologist’s assessments will be compared to calculate the precision, sensitivity, specificity, and accuracy of the ML model. The results will be represented globally and individually for each skin disease class using a confusion matrix and one-versus-all methodology. The time taken to make the diagnosis will also be taken into consideration. Results Patient recruitment began in June 2021 and lasted for 5 months. Currently, all patients have been recruited and the images have been shown to the GPs and dermatologists. The analysis of the results has already started. Conclusions This study will provide information about ML models’ effectiveness and limitations. External testing is essential for regulating these diagnostic systems to deploy ML models in a primary care practice setting.
To investigate the influencing factors on support for tourism development and perceived economic benefits in the context of ski tourism

ABSTRACT This study examines the effects of influencing factors on support for tourism development and perceived economic benefits including community attachment, emotional solidarity and interest for participation in snow ski tourism in Iran. In addition, the mediation role of perceived economic benefits between the influencing factors and support for tourism development is examined. The present study relies on a survey of 300 residents of Pooladkaf, a recently known snow ski resort in Iran where tourism is still at its emerging stage. Partial least squares – structural equation modelling has been employed to analyse the data. Evidence from the study indicates that emotional solidarity has positive effect on support for tourism development. However, the hypothesized path relationships between community attachment and resident’s interest in participation were not supported. The study also shows that emotional solidarity and interests have positive effects on perceived economic benefits, and indirectly on support for tourism development through perceived economic benefits. The study makes an important theoretical contribution to the extant literature by way of applying a revised framework of social exchange theory to investigate the effects of community attachment, emotional solidarity and interest in participation on perceived economic benefits and support for tourism development in the context of ski tourism.
The Company’s Financial Performance Before and After Acquisition (Empirical Study at PT. Eagle High Plantation, Indonesia)

This research aims to determine the differences in the financial performance of PT. Eagle High Plantation before and after being acquired, in 2010-2020. Financial performance is measured using 12 financial ratios: Current Ratio, Quick Ratio, Cash Ratio, Debt to Equity Ratio, Debt to Asset Ratio, Long Term Debt to Equity Ratio, Net Profit Margin, Return on Assets, Return on Equity, Total Assets Turn Over, Fixed Asset Turn Over, Working Capital Turn Over. The research design used in this research is the comparative quantitative design. The data collected was secondary data and was collected using the documentation technique. The data analysis method used in this research was the data normality test and the paired sample t-test using SPSS version 21 application. The results of this research indicate that three ratios have differences before and after being acquired: Net Profit Margin, Return on Assets, and Return on Equity. Meanwhile, nine ratios show no differences before and after being acquired, namely Current Ratio, Quick Ratio, Cash Ratio, Debt to Equity Ratio, Debt to Asset Ratio, Long Term Debt to Equity Ratio, Total Asset Turn Over, Fixed Asset Turn Over, and Working Capital Turn Over.
Female and Rural School Students Show More Positive Attitudes toward Disability during Physical Education Lessons

Physical education (PE) lessons offer an excellent opportunity to encourage participation and learning for students with and without disabilities. However, there are still barriers that prevent educative inclusion (EI) from being achieved, with negative attitudes being one of the major issues. This study aimed to explore students without disabilities’ attitudes toward their peers with disabilities in the second stage of Primary Education, examining possible differences according to sex (male or female) and school location (urban or rural). The Scale of Attitudes toward Students with Disabilities in Physical Education–Primary Education (SASDPE-PE), a four-item instrument with a five-point Likert scale ranging from 1 (strongly disagree) to 5 (strongly agree), was administered to 545 Spanish students aged 9 to 12 years old. The results revealed that girls and students from rural schools showed more positive attitudes toward their peers with disabilities during the PE lessons; differences were significant in both cases. Thus, according to our findings, the SASDPE-PE is a practical tool to assess attitudes, even after an attitude-change programme. Furthermore, PE attitude-change programmes should be implemented, especially considering male students and those enrolled in urban schools.
Delivering a psychosocial program for older people living in retirement homes during the Covid‐19 pandemic: A process evaluation and recommendations for community interventions

Abstract The Covid‐19 pandemic lockdown regulations caused retirement homes to temporarily ban in‐person visitation potentially increasing the mental health risks of older people. An opportunity arose for a multistakeholder community collaboration to design a mental health program for older people. To evaluate the process of delivering a 12‐week psychosocial program aimed at preventing loneliness, countering boredom, and providing older people in restricted settings with education about Covid‐19 during the lockdown, in Durban, South Africa. A qualitative retrospective design was used. Data from two focus groups and six semistructured individual interviews conducted with stakeholders (volunteers, social workers, and residents) postproject were analyzed using reflexive thematic analysis. Stakeholders had varied experiences of the project, in terms of content, processes of engagement, and implementation, resulting in five themes. The study concluded with recommendations. A strong need exists for multistakeholder community collaborations when implementing a program where the context restricts physical access.
Challenges for the FIFO/DIDO workforce in the Australian construction industry: Impacts on health, safety and relationships

Since 2000, Australia has seen a large growth in the mineral, resource and infrastructure sectors, with operations expanding to rural and remote locations, leading to an increase in demand for personnel to work fly-in, fly-out (FIFO) or drive-in, drive out (DIDO) rosters. Such models of work have become increasingly popular as it takes into account the relatively short lifespan of sites, and is considered more economical than building permanent accommodation or paying for rent, helping organisations remain economically competitive. While there are many organisational benefits to employing FIFO/DIDO rosters, there are frequently cited adverse effects on the workers themselves. The issues in employing these workforces are becoming more apparent, and include a range of physical, mental, psychosocial, safety and community challenges. The aims of this study were to: 1. Understand more clearly how employee family relationships are affected by the FIFO/DIDO working environment and investigating solutions. 2. Investigate the psychosocial health implications for employees in a FIFO/DIDO working environment and seeking recommendations for change. 3. Assess the impact of FIFO/DIDO travel on workplace health and safety incidents, and 4. Examine f rosters, shifts, work hours, job design and productivity demands as to how best design a safe, healthy and productive work environment for FIFO/DIDO employees. In conjunction with Australian government and industry partners, the projects agreed methodology consisted of four major phases. First, a desktop review was undertaken of the key documents including research literature and reports. Second, the information was used to help formulate a brief survey designed to examine psychosocial and organisational safety climate, rosters and shifts and integration of the frequently -used Copenhagen Psychosocial Questionnaire. Third, the review of literature also assisted in the development of semi-structured interview questions for the focus groups. The final phase was the analysis of the data and formulation of key recommendations. This paper addresses the research concerns and provides data and respondent commentary to more fully understand the mutual impacts on workplace health and safety and the personal and social relationships of this important workforce, and to explore strategies and actions that better meet the needs of employers, employees and their families.
Triglyceride to high density lipoprotein cholesterol ratio is elevated in patients with complicated type 2 diabetes mellitus

Introduction/Aims: Microvascular and macrovascular complications lead to recurrent hospital admissions, hospitalizations, disability, and death in the course of type 2 diabetes mellitus (T2DM). Triglyceride to HDL cholesterol ratio (THR) is associated with insulin resistance. We aimed to find out whether there is a relationship between THR and diabetic complications in patients with T2DM. Methods: Patients with T2DM were enrolled in the study. The study population was divided into two groups according to the presence or absence of diabetic complications. Characteristics and laboratory data of the patients with (group A) and without (group B) diabetic complications were compared. Results: Median THR values of the groups A and B were 3.86 (0.33-53.38) and 2.86 (0.63-17.88), respectively (p = 0.006). THR level was significantly and positively correlated with glycated hemoglobin (HbA1c) (r = 0.12, p = 0.04) and fasting glucose levels (r = 0.14, p = 0.02). Conclusion: We suggest that THR should be monitored in patients with type 2 diabetes mellitus in order to detect diabetic microvascular complications earlier. Increased THR levels should prompt further investigation of diabetic complications in this population.
Dialect levelling and Cockney diphthong shift reversal in South East England: the case of the Debden Estate

This article explores an instance of dialect levelling in South East England, the reversal of Cockney diphthong shift. We trace this reversal through an apparent-time analysis of 52 speakers from Debden, a community in Essex with East London heritage. Dynamic vowel analyses of word-list and passage data suggests a reversal of the diphthong shift towards SSBE targets which has occurred most abruptly in those born after 1992 potentially as a result of increased social mobility in this generation. We compare the results in Debden to previous findings in the south-eastern towns of Milton Keynes and Reading where apparent-time change was also observed away from a shifted vowel system and towards SSBE targets (Kerswill & Williams 2000, 2005). In diverse areas of South East England, a common process of levelling towards the pan-regional standard is present which is not occurring exclusively as a result of dialect contact or face-to-face interaction. Nonetheless, each community exhibits a distinct trajectory and timing of language change which can be attributed to different patterns of movement and resettlement and, in particular, access to social mobility and the retention of community networks.
Analyzing How Research on Telepsychology has Changed as a Result of
 the Coronavirus Pandemic

The Coronavirus pandemic has had a tremendous effect on all areas of life, perhaps the most salient being the rapid transition to remote life. This paper aims to understand how that shift has impacted academic work produced in the field of telepsychology. We used a variety of Natural Language Processing (NLP) techniques to explore keywords, named entities, topics, and more across articles published between 2016 and 2021. Furthermore, we compared the results for those articles published before 2020 and the outbreak of the COVID-19 Pandemic with those published during the pandemic in order to find the changes that have occurred as a result. We identified three major groups in the literature: 1. Implementation, barriers, and evidence-based treatment; 2. Training and ethics; and 3. Covid-19 and Stress related disorders. We also identified major shifts during the pandemic towards discussing stress and stress-related disorders and away from discussing depression and self-help technologies. This paper summarizes some of the existing research on telemental health and provides a model for systematically applying NLP to identify trends in literature.
Biodegradability assessment of scale inhibitors from oil industry

Abstract A frequent problem in the oil industry is the formation of scale. To minimize this, it is necessary to use additives, which usually enrich the environment, thus promoting microbial growth and inactivation of products. This work evaluated the growth of Pseudomonas aeruginosa and Shewanella algae strains on three scale inhibitors: phosphonate, ethylene glycol combined to amino-ethanol and an organic acid copolymer. Samples containing phosphonate and organic acid copolymer stimulated the growth of P. aeruginosa strains, while ethylene glycol acted as a biocide for S. algae. Furthermore, the samples were used as a source of nutrients by the tested strains.
Influence of Technology Adoption on Recruitment Process: a Case of Liquid Telecom Company

Using technology, like social media, application tracking mechanisms, and even Artificial Intelligence (AI) and blockchain, to assist talent hiring, the traditional method of recruitment has changed significantly in recent years. The goal of this study was to provide some understanding of the current practices of using technology in the hiring process. In addition, the goal of this study was to determine how technological tools have altered the hiring process and whether technology has aided recruitment. The research found that technology has had a significant impact on the hiring process based on the data collected from various respondents. Literature revealed that IT technology is becoming increasingly important in the hiring process. Companies, on the other hand, are clamoring for IT to help them cut costs, improve service, and increase efficiency.
Innovative Use of Force Field Analysis: Factors Influencing Technology-Enabled Change

There remains a limited understanding of the factors that contribute to effectively managing technology-enabled change. Understanding the process of effective technology implementation is significant to many fields and government agencies, as organizations must do more tasks with less resources. To better understand technology-enabled change, this exploratory case study applied a unique conceptual framework consistent of the synthesis of a force field analysis and theories of change through technology insertion. Thirteen participants provided data through interviews, field observations, and a questionnaire. Findings revealed communication issues, a fundamental misconception in training, and a false assumption that most personnel easily acquire computer literacy.
Digital curation through the lens of disciplinarity: The development of an emerging field

Digital curation is both maturing within the information disciplines and becoming increasingly embedded in practice. We are observing an increase in employment opportunities, education and training, and research in the area of digital curation. However, it is still unclear how and where the transmission of this knowledge and skills set fits within higher education. The purpose of this study was to explore the development of digital curation as an academic field by conducting an in-depth analysis of how this area is evolving. The research questions addressed were: Is digital curation emerging as an autonomous discipline? Where does digital curation fit within the educational landscape? The methodologies employed were scoping the literature, content analysis of published literature in the area of digital curation, and interviews with individuals engaged in the area. In this dissertation, the conceptual model put forth by D’Agostino (2012), which views a discipline as the interaction of ten elements that characterize a discipline interpreted within a framework of “shallow consensus” was used. Five key themes emerged from the data analysis: terminology, collaboration, multiple discipline engagement, education, and areas of professional and scholarly focus. Findings suggest that digital curation has not emerged as an autonomous discipline, but does meet several of the criteria to indicate its potential for emergence. Although education for this area fits well in coordination with the information disciplines, skill development is important across all domains. This study provided markers for gauging the progress of digital curation as