Miracle-dz/UniFAR-FTUs huggingface dataset:
COVID-19 and MS disease-modifying therapies

Objective To address concerns regarding the effect of MS disease-modifying therapies (DMTs) on the expression of coronavirus 2019 (COVID-19). Methods Review of the current state of knowledge regarding the viral etiology of COVID-19, mechanisms of injury by SARS-CoV-2 infection, and the effect of individual DMTs on the risk of infection and COVID-19 disease expression. Results Although data are limited, MS DMTs do not obviously increase the risk of acquiring symptomatic SARS-CoV-2 infection. The severe morbidity and mortality of SARS-CoV-2 appear to be largely the consequence of an overly robust immune response rather than the consequence of unchecked viral replication. The effects of specific MS DMTs on the immune response that may increase the risk of impaired viral clearance and their potential counterbalancing beneficial effects on the development of COVID-19–associated acute respiratory distress syndrome are reviewed. Conclusion Although there is currently insufficient real-world experience to definitively answer the question of the effect of a specific MS DMT on COVID-19, registries presently in nascent form should provide these answers. This review provides an approach to addressing these concerns while the data are being accumulated. Early insights suggest that the risk of infection and associated morbidity of COVID-19 in this population is little different than that of the population at large.
Reproduction of cavity‐nesting birds in pesticide‐sprayed apple orchards in southern Ontario, Canada, 1988–1994

Egg fertility, clutch size andeggandchick survival and pesticideexposureof tree swallows (Tachycineta bicolor) and eastern bluebirds (Sialia sialis) were measured annually using nest boxes in sprayed and nonsprayed apple orchards in southern Ontario, Canada, during 1988–1994. Associations were examined between reproductive rates and historical organochlorine residues in eggs as well as the degree of exposure and toxicity of pesticides applied during the study period. Because many pesticides in current use are not persistent in wildlife tissues, a toxicity score was developed to describe the exposure for each nest. The toxicity score was calculated as the product of the extent of the orchard sprayed and the application rate of the chemicals, divided by an acute reproductive toxicity index of each chemical. Total organochlorine concentrations in tree swallow eggs were 0.74 to 3.47 μg/g, and in eastern bluebird eggs, these values ranged from 0.47 to 106.3 μg/g. More than 90% of the residue in eggs was pp′DDE. There was a significant increase in unhatched eggs in bluebirds as organochlorine levels increased in eggs. There were significant associations between toxicity scores of current‐use pesticides and at least one avian reproductive parameter in every year of the study, but the reduction in reproductive rates associated with pesticides did not exceed 14%, for either species, in any year. Reduced reproduction occurred in 6 years in tree swallows but for bluebirds, this occurred in only 4 years.
Pseudomonas tolaasii in mushroom (Agaricus bisporus) crops: activity of formulations of 2‐bromo‐2‐nitropropane‐1,3‐diol (bronopol) against the bacterium and the use of this compound to control blotch disease

The bactericidal activity of 2-bromo-2-nitropropane-1,3-diol (bronopol) against Pseudomonas tolaasii, the causative organism of mushroom bacterial blotch, is enhanced by the addition of Tween 80, EDTA and phenylethanol. Results of tests with this pseudomonad confirm that bronopol is more active in alkaline solutions and enhancement of the bactericidal activity of this compound can be obtained by adding calcium carbonate, or mushroom casing (limestone and peat). Quantitative observations show that sterility can be achieved with bronopol at 100 µg/ml in 24 h following artificial inoculation of casing with Ps. tolaasii in glass flasks. On miniature mushroom beds in controlled environments a single application of bronopol, in tap water during routine watering, controls bacterial blotch disease. Bronopol is a slow-acting bactericide, destroying Ps. tolaasii in mushroom casing and effecting control of bacterial blotch disease.
Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan

An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells.
Intrathecal immunoreactivity in people with or without previous infectious mononucleosis

The risk of developing multiple sclerosis (MS) increases (OR: 3.1) after infectious mononucleosis (IM). However, the nature of this link is obscure. We tested the hypothesis that IM might incur long‐term sequelae, including low‐key inflammatory activity, with characteristics of an MS endophenotype (or presymptomatic trait) and that assays of MS‐relevant cyto‐/chemokines in the cerebrospinal fluid (CSF) post‐IM may show a trend in this direction.
The Increased Effectiveness of Resistance Training on Unstable vs. Stable Surfaces on Selected Measures of Physical Performance in Young Male Soccer Players

Abstract Sanchez-Sanchez, J, Raya-González, J, Ramirez-Campillo, R, Chaabene, H, Petisco, C, and Nakamura, FY. The increased effectiveness of resistance training on unstable vs. stable surfaces on selected measures of physical performance in young male soccer players. J Strength Cond Res 36(4): 888–894, 2022—To examine the effects of 10-week (2/wk) resistance training on stable vs. unstable surfaces on selected measures of physical performance in young male soccer players, national-level U19 players participated in this study. They were randomly allocated to an unstable resistance training group (uRT, n = 27) or a stable resistance training group (sRT, n = 28). Before and after the training, horizontal jumping with dominant (Hop D) and nondominant leg (Hop non-D), repeated sprint ability (RSA best time [RSAbest] and RSA mean time [RSAmean]), change-of-direction (COD) speed (Illinois COD test), and aerobic endurance (YoYo Intermittent Recovery Test Level 1 [YoYo IR1]) were assessed. To establish the effects of the interventions on the dependent variables, a 2 (group: uRT and sRT) × 2 (time: pre, post) analysis of variance with repeated measures on time was computed. A significant main effect of time was observed for Hop non-D, RSAbest, and RSAmean (p = 0.003–0.06, effect size [ES] = 0.06–0.15). Furthermore, significant group × time interactions were shown for RSAbest (p = 0.007, ES = 0.13) and RSAmean (p = 0.002, ES = 0.2). Post hoc analysis revealed significant pre- to post-training improvements for RSAbest (p = 0.002, ES = 0.35) and RSAmean (p = 0.0002, ES = 0.36) in the uRT. In the sRT, however, no significant pre–post performance changes were observed in RSAbest and RSAmean. In conclusion, 10 weeks of an in-season resistance training on unstable conditions in addition to regular soccer training was effective in improving repeated-sprint ability performance in youth male elite soccer players including maximal linear sprinting and the ability to perform repeated sprint.
Functional effect of vaterite – the presence of an alternative crystalline structure in otoliths alters escape kinematics of the brown trout

ABSTRACT The fast-start escape response is the main locomotor behaviour observed in fish to evade predatory attacks and thereby increase their probability of survival. Thus far, this high-speed sensory motor control has been extensively studied in relation to extrinsic factors. In contrast, there has been surprisingly little consideration of intrinsic individual factors that can mediate sensorial perception, such as inter-individual variability in mechanosensory systems. The inner ear of teleost fishes is composed of otoliths that play an important role in hearing and balance functions. While sagittal otoliths are normally composed of aragonite in many fish species, the inclusion of vaterite (an abnormal crystalline structure) has been reported in a number of individuals from different environments. There is currently strong theoretical and empirical evidence that vaterite deposition has a negative impact on auditory sensitivity in fishes. While the functional/behavioural implications of this defect on otolith-related hearing function has been hypothesised, it has remained largely untested experimentally. Here, using juvenile (0+ years) Salmo trutta originating from the wild in experimental conditions, we report for the first time that the deposition of calcium carbonate in its crystalline vateritic polymorph has significant pervasive effects on the escape kinematics of fish. The presence of an alternative crystalline structure in otoliths is likely to alter fish behaviour in ways that decrease survival. We also report that altered behaviour in individuals with vateritic otoliths is partially compensated for by the presence of a functional lateral line. Such functional compensation suggests more slight consequences, if any, in the wild. Summary: The presence of vaterite alters fish behaviour in ways that are likely to decrease survival.
Comparative Limnology of Several Reservoirs in Central India

Twenty four reservoirs in Central India were investigated for their physical, chemical and biological features. These reservoirs differed significantly in their size, physical features, chemical composition and vegetation. Three medium and major reservoirs recorded comparatively low electrical conductivity. All the eighteen minor reservoirs showed high conductivity and low transparency since they were all situated in densely populated urban areas polluted by human faeces and domestic sewage. The most abundant ions in water are calcium, carbonate and chloride. The phytoplankton was found to be dominated by Cyanophyceae. Rotifers dominated among zooplankton. All the minor reservoirs are highly eutrophicated. Among the major reservoirs Tawa Reservoir is oligotrophic while others are mesotrophic to eutrophic in nature.
The F-Box-Like Protein FBL17 Is a Regulator of DNA-Damage Response and Colocalizes with RETINOBLASTOMA RELATED1 at DNA Lesion Sites1[OPEN]

The mutation of FBL17 leads to a strong upregulation of genes involved in DNA damage and repair processes, and FBL17 protein is recruited at nuclear DNA lesion foci upon double-strand break induction. In Arabidopsis (Arabidopsis thaliana), the F-box protein F-BOX-LIKE17 (FBL17) was previously identified as an important cell-cycle regulatory protein. FBL17 is required for cell division during pollen development and for normal cell-cycle progression and endoreplication during the diploid sporophyte phase. FBL17 was reported to control the stability of the CYCLIN-DEPENDENT KINASE inhibitor KIP-RELATED PROTEIN (KRP), which may underlie the drastic reduction in cell division activity in both shoot and root apical meristems observed in fbl17 loss-of-function mutants. However, whether FBL17 has other substrates and functions besides degrading KRPs remains poorly understood. Here we show that mutation of FBL17 leads not only to misregulation of cell cycle genes, but also to a strong upregulation of genes involved in DNA damage and repair processes. This phenotype is associated with a higher frequency of DNA lesions in fbl17 and increased cell death in the root meristem, even in the absence of genotoxic stress. Notably, the constitutive activation of DNA damage response genes is largely SOG1-independent in fbl17. In addition, through analyses of root elongation, accumulation of cell death, and occurrence of γH2AX foci, we found that fbl17 mutants are hypersensitive to DNA double-strand break-induced genotoxic stress. Notably, we observed that the FBL17 protein is recruited at nuclear foci upon double-strand break induction and colocalizes with γH2AX, but only in the presence of RETINOBLASTOMA RELATED1. Altogether, our results highlight a role for FBL17 in DNA damage response, likely by ubiquitylating proteins involved in DNA-damage signaling or repair.
Omega-3 fatty acid supplementation in severe brain trauma: case for a large multicenter trial.

1Department of Neurosurgery, NorthShore University HealthSystem, Evanston; 2University of Chicago, Pritzer School of Medicine, Chicago; 3Department of Neurosurgery, John H. Stroger Jr. Hospital of Cook County, Chicago; 4Department of Neurosurgery, Advocate Good Samaritan Hospital, Downers Grove; 5Midwestern University, Chicago College of Osteopathic Medicine, Downers Grove, Illinois; and 6The Inflammation Research Foundation and Zone Labs Inc., Peabody, Massachusetts
RELEASE OF DISSOLVED ORGANIC MATTER IN A TROPICAL STRAIN OF SYNURA PETERSENII (CHRYSOPHYCEAE) GROWN UNDER HIGH IRRADIANCES

Abstract Carbon (14C) assimilation and the release of labeled dissolved organic carbon (DO14C) by Synura petersenii Korshikov (Chrysophyceae) were investigated at a range of irradiances (100–1260 μmol photons m−2 s−1) in axenic batch cultures. At up to 1260 μmol m−2 s−1, carbon assimilation was not saturated, although a 25% chlorophyll-a reduction in relation to the initial value at 1000 μmol m−2 s−1 and 28% at 1260 μmol m−2 s−1 was observed. The DO14C release was low at all irradiances investigated and dependent on carbon fixation; the highest release (4.8% of the total 14C assimilated) was observed at 1260 μmol m−2 s−1. In a second experiment, 14C assimilation by S. petersenii was measured at 130 μmol m−2 s−1. The subsequent loss of labeled particulate organic carbon (PO14C) and release of DO14C were determined during a 5-h period in which cells were incubated in nonlabeled medium at different irradiances. At 2000 μmol m−2 s−1 there was a 20.6% PO14C loss. The values of DO14C release were low for both 2.
Unrealistic Optimism in the Time of Coronavirus Pandemic: May It Help to Kill, If So—Whom: Disease or the Person?

Objective: The results of numerous empirical studies have showed the occurrence of so-called unrealistic optimism. Thus, we aimed to investigate whether in the situation of an imminent coronavirus pandemic, people would still perceive themselves as being less exposed to the disease than others. Methods: Survey studies were conducted to examine the level of unrealistic optimism. Participants (n = 171, 67.3% of women) in a subjective way judged the risk of their coronavirus infection and the likelihood that this would happen to an average student of the same sex from their class. The survey was conducted in three waves: prior to the announcement of the first case of coronavirus (2–3 March), immediately after that announcement (5–6 March), and a few days later (9–10 March). Results: We showed that women estimated the chances of being infected as significantly higher (M = 4.52, SD = 2.079; t = 2.387; p = 0.018; Cohen’s d = 0.393) than men (M = 3.71, SD = 2.042). The phenomenon of unrealistic optimism was observed especially in men (as compared to other male participants) as it appeared in all three measures (M (you) = 3.95 vs. M (other male student) = 4.63; M = 3.71 vs. M = 4.68, and M = 4.46 vs. M = 5.38 in phase one, two, and three, respectively; p ≤ 0.006 for all comparison), but also in women in the last two measures (M (you) = 4.55 vs. M (other female student) = 4.95, and M = 4.99 vs. M = 5.38 in phase 2 and 3, respectively; p ≤ 0.012 for both comparisons). Conclusions: The study revealed a fairly general occurrence of unrealistic optimism, which was mainly observed in men as it appeared in all three measures, but also in women in the last two measures. This result is important for health experts who are responsible for making people comply with regulations concerning social distancing, putting masks on to stop infection, and staying at home. It is possible that unrealistically optimistic people will behave much less in line with the aforementioned recommendations, causing coronavirus to spread widely.
Asymmetrical gait kinematics of free-ranging callitrichine primates in response to changes in substrate diameter and orientation

ABSTRACT Arboreal environments present considerable biomechanical challenges for animals moving and foraging among substrates varying in diameter, orientation and compliance. Most studies of quadrupedal gait kinematics in primates and other arboreal mammals have focused on symmetrical walking gaits and the significance of diagonal sequence gaits. Considerably less research has examined asymmetrical gaits, despite their prevalence in small-bodied arboreal taxa. Here, we examined whether and how free-ranging callitrichine primates adjust asymmetrical gait kinematics to changes in substrate diameter and orientation, as well as how variation in gait kinematics affects substrate displacement. We used high-speed video to film free-ranging Saguinus tripartitus and Cebuella pygmaea inhabiting the Tiputini Biodiversity Station, Ecuador. We found that S. tripartitus used bounding and half-bounding gaits on larger substrates versus gallops and symmetrical gaits on smaller substrates, and also shifted several kinematic parameters consistent with attenuating forces transferred from the animal to the substrate. Similarly, C. pygmaea shifted from high-impact bounding gaits on larger substrates to using more half-bounding gaits on smaller substrates; however, kinematic adjustments to substrate diameter were not as profound as in S. tripartitus. Both species adjusted gait kinematics to changes in substrate orientation; however, gait kinematics did not significantly affect empirical measures of substrate displacement in either species. Because of their small body size, claw-like nails and reduced grasping capabilities, callitrichines arguably represent extant biomechanical analogs for an early stage in primate evolution. As such, greater attention should be placed on understanding asymmetrical gait dynamics for insight into hypotheses concerning early primate locomotor evolution. Summary: Free-ranging callitrichine primates adjust aspects of asymmetrical gait kinematics to promote stability when moving over arboreal substrates varying in diameter and orientation angle.
The most common comorbidities in patients with Ehlers-Danlos syndrome: a 15-year nationwide population-based cohort study

Abstract Objectives Ehlers-Danlos syndrome (EDS) constitutes a group of connective tissue diseases with variable organ dysfunction. We aimed to examine the comorbidity burden in patients with EDS. Methods A nationwide population-based cohort study linking data from Danish registers from the year 2000–2014. The EDS cohort was identified using the International Classification of Diseases version 10 (ICD-10) EDS code. The control cohort was formed from the Danish general population by randomly matching the EDS cohort in a ratio of 1:25 by sex and date of birth. Hospital contacts were used to identify the most frequently occurring ICD-10 codes. We investigated the frequencies of the disease categories and unique ICD-10 codes and compared these between the cohorts. Results The EDS cohort included 1,319 patients and the control cohort 46,700 patients. All disease categories and ICD-10 codes were significantly more frequent within the EDS cohort, especially those related to common manifestations of EDS. Other comorbidities such as asthma, pneumonia, gastrointestinal functional disorders, and hernias were also significantly more common in the EDS cohort. Conclusions The most common comorbidities in Danish patients with EDS were gastrointestinal functional disorders, hernias, asthma, pneumonia, and osteoporosis. The causality between these comorbidities and EDS should be investigated further. Implications for Rehabilitation Ehlers-Danlos syndrome constitutes a group of connective tissue diseases causing a variable range of organ dysfunction. The comorbidity burden for patients with Ehlers-Danlos syndrome was unexplored previously. This study showed that the most common comorbidities in Danish patients with Ehlers-Danlos syndrome are gastrointestinal functional disorders, hernias, asthma, pneumonia, and osteoporosis.
BRCA1 promoter methylation and clinical outcomes in ovarian cancer: an individual patient data meta-analysis.

BACKGROUND BRCA1 methylation has been associated with homologous recombination deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal/ovarian cancer (OC) do not consistently support improved survival following platinum chemotherapy. We examine the characteristics of BRCA1-methylated OC in a meta-analysis of individual participant data. METHODS 2636 participants' data across 15 studies were analyzed. BRCA1-methylated tumors were defined according to their original study. Associations between BRCA1 methylation and clinico-pathological characteristics were evaluated. The effects of methylation on overall survival (OS) and progression-free survival (PFS) were examined using mixed-effects models. All statistical tests were two-sided. RESULTS 430 (16.3%) tumors were BRCA1-methylated. BRCA1 methylation was associated with younger age and advanced-stage high-grade serous OC. There were no survival differences between BRCA1-methylated and non-BRCA1-methylated OC (median PFS = 20.0 vs 18.5 months, HR = 1.01, 95% CI = 0.87-1.16, P=0.98; median OS = 46.6 vs 48.0 months, HR = 1.02, 95% CI = 0.87-1.18, P=0.96). Where BRCA1/2 mutations were evaluated (n = 1248), BRCA1 methylation displayed no survival advantage over BRCA1/2 intact (BRCA1/2 wild type non-BRCA1-methylated) OC. Studies used different methods to define BRCA1 methylation. Where BRCA1 methylation was determined using methylation-specific PCR and gel electrophoresis (n = 834), it was associated with improved survival (PFS: HR = 0.80, 95% CI = 0.66-0.97, P=0.02; OS: HR = 0.80, 95% CI = 0.63-1.00, P=0.05) on mixed-effects modelling. CONCLUSION BRCA1-methylated OC displays similar clinico-pathological features to BRCA1-mutated OC, but is not associated with survival. Heterogeneity within BRCA1 methylation assays influences associations. Refining these assays may better identify cases with silenced BRCA1 function and improved patient outcomes.
Disability and quality of life before and during the COVID-19 outbreak: A cross-sectional study in inflammatory bowel disease patients

Background/Aim: Inflammatory bowel disease (IBD) is a chronic disorder affecting patients' health-related quality of life (HRQoL) which adds to their disability. Little is known about the impact of the COVID-19 pandemic on HRQoL of IBD patients. We aimed to evaluate HRQoL in IBD patient's pre- and post-COVID-19 pandemic using the IBD-disk questionnaire and explore associations between socio demographic factors, disease types, severity and impaired HRQoL in patients with IBD. Patients and Methods: A cross-sectional study was conducted at a tertiary care centre in Saudi Arabia between November 2019 and March 2020 at the outpatient IBD clinics. The HRQoL of patients was assessed using the 10-item IBD-disk questionnaire. Results: A total of 59 IBD patients (40 Crohn's disease, 19 Ulcerative colitis) with a mean disease duration of 3.5 years were included. Most of the patients (77.97%) were on biologics while 35.59% were on immune modulators, 16.94% on 5-ASA, and 3.38% were on corticosteroids. There was no difference between any of the 10 IBD-disk variables pre and post-COVID-19 pandemic apart from the perception of body image, where there was a slightly more negative perception with an increase from 2.53 to 3.39 (P = 0.05) There was no significant difference in HRQoL between patients with ulcerative colitis and Crohn's disease in any of domains. Conclusion: The current study showed that disability and HRQoL appears to be unaffected by the COVID-19 pandemic among our cohort, however further studies with longer follow up and larger sample size is needed.