Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychological determinants of the attitude towards vascular interventions in patients with lower limb ischaemia

BACKGROUND Critical lower limb ischaemia is associated with a 20% annual risk of amputation and death. It is necessary to activate patients’ personal resources which comprise mental dispositions needed to effectively cope with the disease. The objective of the study was to evaluate the correlation between the attitude toward the vascular reconstruction and self-efficacy (SE), health locus of control (HLoC) and own life quality (QOL) assessment in patients with critical lower limb ischaemia. PARTICIPANTS AND PROCEDURE The study involved 64 patients with critical lower limb ischaemia (Rutherford 4 and 5), 26 women and 38 men. Four scales were applied during primary admission: the Generalized Self-Efficacy Scale; the Satisfaction with Life Scale; the Multidimensional Health Locus of Control Scale; and the visual scale revealing attitude to vascular reconstruction. RESULTS The attitude to the vascular reconstruction was positive (M = 8.50). The lowest grades were given by those hospitalised several times during follow-up (M = 8.30); women expressed low grades (M = 7.71). An overall positive correlation was found between the positive attitude to the surgery and self-efficacy (p = .012), internal HLoC (p = .041) and external locus (p = .026). In the patients who died within six months from baseline assessment, no correlations were found. In subjects with no readmission, a correlation was found between positive attitude to surgery and the external personal HLoC (p = .023). In patients with subsequent readmissions, a correlation was found between the originally positive attitude to the surgery and poor self-efficacy (p = .009). CONCLUSIONS Patients with weak mental dispositions cannot cope with difficult situations and show a tendency to experience strong emotions, concentrating on their deficiencies, resulting in decreased motivation and feeble engagement in treatment. Poor mental disposition influences the final outcome of the vascular reconstruction.
Splitting ofthe¢ssionyeast septum

In cell-walled organisms, a cross wall (septum) is produced during cytokinesis, which then splits in certain organisms to allow the daughter cells to separate. The formation and the subsequent cleavage of the septum require wall synthesis and wall degradation, which need to be strictly coordinated in order to prevent cell lysis. The dividing fission yeast (Schizosaccharomyces) cell produces a three-layered septum in which the middle layer and a narrow band of the adjacent cell wall can be degraded without threatening the integrity of the separating daughter cells. This spatially very precise process requires the activity of the Agn1p 1,3-a-glucanase and the Eng1p 1,3-b-glucanase, which are localized to the septum by a complex mechanism involving the formation of a septin ring and the directed activity of the exocyst system. The Sep1p-Ace2p transcription-factor cascade regulates the expression of many genes producing proteins for this complex process. Recent advances in research into the molecular mechanisms of separation and its regulation are discussed in this review.
Nasopharyngeal Flora of Children Requiring Pressure Equalizing Tubes

Background and Objectives: Children with recurrent middle ear disease (RMED) that is refractory to medical treatment often require ventilation tubes insertion. This may be due to host, environment or microbes related factors. The latter can present a challenge either due to their resistance to antimicrobials or for being uncommon causative pathogens. The aims of this study are to evaluate nasopharyngeal flora in RMED, and to identify associated predictive clinical parameters. Materials and Methods: Consecutive children with RMED undergoing tubes insertion were prospectively recruited. Demographic, clinical and intraoperative data collected. Punch biopsy from adenoid bed was sent for culture. The Kruskal Wallis test was used to compare the different parameters. Analysis was conducted using SPSS software. Results: We enrolled 84 patients; aged 1 – 9 yrs (mean 3.62). Recurrent respiratory tract infections coincided with RMED in 36.9%. We recovered Hemophilus influenza type b in 23.6%, Moraxella catarrhalis in 14.6%, and Streptococcus pneumoniae in 5.5%. Uncommon RMED bacteria (e.g β Hemolytic streptococcus, Staphylococcus aureus) formed 21.8%; 4.5% of all cultures grew Hemophilus influenza, non-type b. Patients with RMED coinciding with respiratory tract infections, and those with chronic purulent rhinorrhea were more likely to have uncommon RMED organisms (P<0.05). Conclusion: Children with RMED associated with chronic purulent rhinorrhea, or upper respiratory tract infections may benefit from nasopharyngeal culture to properly guide treatment with antibiotics. This may be an important step before deciding placing tubes in these children.
Prescribing Antibiotics for pediatric dental patients in Jordan ; knowledge and attitudes of dentists

Prescribing Antibiotics for pediatric dental patients in Jordan; knowledge and attitudes of dentists 1 Professor, Faculty of Dentistry, The University of Jordan, Amman, Jordan 2 Assistant Professor, Faculty of Dentistry, The University of Jordan, Amman, Jordan 3 Intern, Dental Department, The University of Jordan Hospital, Amman, Jordan 4 Professor, Faculty of Dentistry, Taibah university, Madina, KSA * Correspondence:
DMD049676 1148..1155

Unsafe use of alcohol results in approximately 2.5 million deaths worldwide, with cirrhosis contributing to 16.6% of reported deaths. Serum insulin levels are often elevated in alcoholism and may result in diabetes, which is why alcoholic liver disease and diabetes often are present together. Because there is a sizable population with these diseases alone or in combination, the purpose of this study was to determine whether transporter expression in human liver is affected by alcoholic cirrhosis, diabetes, and alcoholic cirrhosis coexisting with diabetes. Transporters aid in hepatobiliary excretion of many drugs and toxic chemicals and can be determinants of drug-induced liver injury. Drug transporter expression and transcription factor–relative mRNA and protein expression in normal, diabetic, cirrhotic, and cirrhosis with diabetes human livers were quantified. Cirrhosis significantly increased ABCC4, 5, ABCG2, and solute carrier organic anion (SLCO) 2B1 mRNA expression and decreased SLCO1B3 mRNA expression in the liver. ABCC1, 3–5, and ABCG2 protein expression was also upregulated by alcoholic cirrhosis. ABCC3-5 and ABCG2 protein expression was also upregulated in diabetic cirrhosis. Cirrhosis increased nuclear factor E2–related factor 2 mRNA expression, whereas it decreased pregnane-X-receptor and farnesoid-X-receptor mRNA expression in comparison with normal livers. Hierarchical cluster analysis indicated that expressions of ABCC2, 3, and 6; SLCO1B1 and 1B3; and ABCC4 and 5 were more closely related in the livers from this cohort. Overall, alcoholic cirrhosis altered transporter expression
Fusion of Multimodal Sensor Data for Eﬀective Human Action Recognition in the Service of a Medicine-Oriented Platform

In what has arguably been one of the most troubling periods of recent medical history, with a global pandemic emphasising the importance of staying healthy, innovative tools that shelter patient well-being gain momentum. In that view, we propose a framework that leverages multimodal data, namely inertial and depth sensor-originating data, is integrated in a health care oriented platform, and tackles the crucial issue of detecting patient actions, such as walking, standing and jogging, or even patient falls. To analyse person movement and consequently assess the patient’s condition, an eﬃcient methodology is presented that is two-fold: initially a sophisticated Kinect-based methodology is presented that exploits 3DHOG depth features and the descriptive power of a Fisher encoding scheme. This is complemented by wearable sensor data analysis using time domain features and a robust fusion strategy that provides an eﬀective and reliable recognition methodology. The clas-siﬁcation accuracy reported in a well-known benchmark dataset proves that the presented approach achieves competitive results and validates the applicability and eﬃciency of our human action recognition (HAR) methodology.
The Symptomatic Importance of Nicotine in Schizophrenia

The tendency of people suffering from schizophrenia to consume more cigarettes and thus put themselves at a much greater risk of cardiovascular and respiratory disease is well-known. This is an obvious health consideration for people who are already more vulnerable to ill-health because of a mental illness which is notoriously difficult to manage. There is a wealth of information available detailing the importance of nicotine in the pathophysiology of schizophrenia: some important examples from this body of work will be reviewed here. Chronic Nicotine Replacement Therapy (NRT) such as with 12- or 16-hour transdermal nicotine patches are not appropriate for achieving the necessary improvements in cognitive function in schizophrenia. A better alternative is NRT which replicates the short burst of nicotinergic activity that cigarette smoking provides. Nicotine chewing gum, or more controversially, e-cigarettes, are the two clear candidates. Nicotine inhalators have been largely unsuccessful as agents for the delivery of nicotine, as the sensation that they produce is a reportedly unpleasant one. The use of nicotine gum or e-cigarettes is not something which would necessarily break the habit. In people who suffer from schizophrenia and who are supplementing their deficient endogenous cerebral nicotine with exogenous sources, delivery via gum or e-cigarettes represents a far less toxic route than tobacco cigarettes. In the latter, it is probable that the aromatic hydrocarbons in cigarette smoke also cause the increased metabolism of antipsychotic drugs due to their induction of hepatic catabolic enzymes. This adds another negative factor to tobacco cigarette consumption for people with severe mental illnesses. For a patient group which is already at risk of impaired physical health, prevention of respiratory and cardiovascular pathology is especially important. The success of clozapine and olanzapine as antipsychotic medications is in large part due to their success in improving the deficient sensory gating inherent to schizophrenia. These drugs are also associated with greater success in helping schizophrenic smokers to abstain; both of these aspects can be at least partly attributed to their involvement of cerebral nicotinic receptors. Where it is not possible for the schizophrenic smoker to abstain, then as clinicians, we are duty-bound to research acceptable alternatives to smoking. It is also possible that NRT delivered via safer methods such as gum or e-cigarettes can provide a useful adjunct to antipsychotic treatment. For these reasons, the symptomatic role of intermittent NRT in schizophrenia must be further investigated.
Microsoft Word-82519030-file00

Department of Biopharmaceutics (K.T., Y.U., M.A., T.M., H.W., M.O.), Center for Clinical Pharmaceutical Sciences (T.M., H.W.), and Department of Medical Biopolymer (T.K.), Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862-0973 Kumamoto, Japan; Research Institute for Science and Engineering (H.S., E.T.), Waseda University, 3-4-1 Okubo, Shinjuku, 169-8555 Tokyo, Japan; Department of Surgery, School of Medicine (K.K., H.H), Keio University, 35 Shinano Shinjyuku, 160-8582 Tokyo, Japan; Pharmaceutical Research Center (T.K.), Nipro Corporation, 3023 Nojicho, Kusatsu, 525-0055 Shiga, Japan DMD Fast Forward. Published on April 13, 2009 as doi:10.1124/dmd.109. 027094
H-2 COMPATIBILITY R E Q U I R E M E N T FOR VIRUS-SPECIFIC T-CELL-MEDIATED CYTOLYSIS Eva lua t ion of the Role of H-2I Region and Non-H-2 Genes in Regula

Acute murine lymphocytic choriomeningitis (LCM) ~ is a well documented example of predominantly cell-mediated immunopathology. The experimental evidence leading to this conclusion has been reviewed in extenso recently (1-3). The pathological process in vivo can be monitored in vitro by measuring LCM virus (LCMV)-specific cytotoxic activity of thymus-derived lymphocytes (T cells) for LCMV-infected target cells (4-7). That these cytotoxic T cells may be directly involved in destroying the meninges and ependymal cells is suggested by the fact that they can be isolated with great specific reactivity from cerebrospinal fluid of clinically affected mice (8). Oldstene et al. (9) reported that a small but statistically significant susceptibility difference of two mouse strains could be linked to their H-2 type, possibly reflecting Ir gene control. More recently, with the mouse strains available now, this difference no longer appears to be statistically significant (10). Nevertheless, it was during the attempt to correlate increased susceptibility to acute LCM with the capacity of various mouse strains to generate LCMV-specific T cells with greater cytotoxic activity and quicker than less susceptible mice that the unexpected H-2 restriction of cytolytic activity was originally found (2, 11). Many other T-cell functions were known or were subsequently shown to be restricted by the H-2 gene complex in a similar or different way. For the Thelper function, T cells and bone marrow-derived lymphocytes (B cells) clearly require compatibility at the I but not at the K or D region of H-2 (12, 13).
Phage Display and Molecular Modeling Autoantigen GAD65 Identified by Peptide Conformational Epitopes on the Diabetes

The major diabetes autoantigen, glutamic acid decarboxylase (GAD65), contains a region of sequence similarity, including six identical residues PEVKEK, to the P2C protein of coxsackie B virus, suggesting that cross-reactivity between coxsackie B virus and GAD65 can initiate autoimmune diabetes. We used the human islet cell mAbs MICA3 and MICA4 to identify the Ab epitopes of GAD65 by screening phage-displayed random peptide libraries. The identiﬁed peptide sequences could be mapped to a homology model of the pyridoxal phosphate (PLP) binding domain of GAD65. For MICA3, a surface loop containing the sequence PEVKEK and two adjacent exposed helixes were identiﬁed in the PLP binding domain as well as a region of the C terminus of GAD65 that has previously been identiﬁed as critical for MICA3 binding. To conﬁrm that the loop containing the PEVKEK sequence contributes to the MICA3 epitope, this loop was deleted by mutagenesis. This reduced binding of MICA3 by 70%. Peptide sequences selected using MICA4 were rich in basic or hydroxyl-containing amino acids, and the surface of the GAD65 PLP-binding domain surrounding Lys 358 , which is known to be critical for MICA4 binding, was likewise rich in these amino acids. Also, the two phage most reactive with MICA4 encoded the motif VALxG, and the reverse of this sequence, LAV, was located in this same region. Thus, we have deﬁned the MICA3 and MICA4 epitopes on GAD65 using the combination of phage display, molecular modeling, and mutagenesis and have provided compelling evidence for the involvement of the PEVKEK loop in the MICA3 epitope. The Journal of Immunology, 2000, 165:
INTENTION TO STAY AMONG EMPLOYEES AND THEIR WORK ENGAGEMENT IN THE BUSINESS PROCESS OUTSOURCING (BPO) COMPANIES

The study aims to determine which domain of intention to stay among employees best predicts work engagement among BPO employees in Davao City. This study used quantitative non-experimental research design using correlation method to 100 call center agents as participants working in the BPO companies. Adapted questionnaires were used in the gathering of data. The statistical tools used in data analysis were Mean, Pearson-r and linear regression. Findings showed that the level of intention to stay among employees was high as well as their work engagement. There was a significant relationship between intention to stay among employees and their work engagement. There was significant influence of intention to stay among employees on their work engagement. Person organization fit as domain of intention to stay best predict work engagement of employees. Regression equation was developed to predict work engagement.
Study on the design and switching dynamics of hysteresis current controlled four-leg voltage source inverter for load compensation

In a variable switching frequency control scheme, it is challenging to design the voltage source inverter (VSI) parameters without knowing the maximum and minimum switching frequencies. The switching frequency variation depends on the system parameters. Therefore, the expression for frequency variation in one inverter topology does not hold in other topologies. The design of hysteresis current controlled four-leg shunt active power filter (APF) requires the switching dynamics analysis to ensure satisfactory performance of the inverter. In this study, a detailed analysis on the switching dynamics of hysteresis current controlled four-leg VSI and design of various inverter components for compensating unbalanced and non-linear loads are presented. The results obtained from these analyses can be used in any applications involving hysteresis current controlled four-leg VSI. These results are supported by detailed simulation studies conducted on a three-phase four-leg shunt APF system using Matlab/Simulink. The theoretical studies and design of passive components are also verified by conducting experiments on a prototype of four-leg shunt APF developed in the laboratory.
USAGE OF ANTIMICROBIALS IN POST-OPERATIVE PATIENTS IN A TERTIARY CARE TEACHING RURAL HOSPITAL IN INDIA

Background: Rational antibiotic usage reduces the incidence of Post surgical wound infection but its improper usage can further lead to excessive surgical wound infection and increased drug resistance which further complicates the problem. Proper treatment of postoperative and other hospital acquired infections is essential. Hence to investigate the current scenario in surgical post-operative patients, the present study was undertaken. Objectives: The objective of this study was to assess the current trends of prescribing antibiotics amongst the patients of surgical postoperative unit of UP Rural Institute of Medical sciences and Research, India. Materials and Methods: A descriptive retrospective study was done amongst the patients admitted in the surgical postoperative ward of UP RIMS & R, Saifai, Etawah, India. This study was done by collecting the prescriptions during the months between January 2015 to March 2015. The study was conducted in accordance with the ethical principles of the ethics committee guidelines. We collected data from 142 postoperative patients. Information was collected with respect to Demographic profile, most common case diagnosed, commonly prescribed antibiotics and WHO core indicators were assessed from the inpatients records. Data were analyzed using Microsoft Office Excel 2007 and values were presented descriptively in percentiles. Results: We analyzed the data using the various drug use indicators given by the WHO. The average number of drugs per encounter was 4.98. The most common surgeries in the postsurgical unit ejpmr, 2015,2(4), 328-337 SJIF Impact Factor 2.026 Research Article ISSN 3294-3211 EJPMR EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH www.ejpmr. com *Correspondence for Author Chaudhary K Pankaj Demonstrator of Pharmacology, UP RIMS and R, Etawah, UP, India.
DMD046342 122..131

[F]DPA-714 [N,N-diethyl-2-(2-(4-(2[F]-fluoroethoxy)phenyl) 5,7dimethylpyrazolo[1,5a]pyrimidin-3-yl)acetamide] is a new radioligand currently used for imaging the 18-kDa translocator protein in animal models of neuroinflammation and recently in humans. The biodistribution by positron emission tomography (PET) in baboons and the in vitro and in vivo metabolism of [F]DPA-714 were investigated in rats, baboons, and humans. Whole-body PET experiments showed a high uptake of radioactivity in the kidneys, heart, liver, and gallbladder. The liver was a major route of elimination of [F]DPA-714, and urine was a route of excretion for radiometabolites. In rat and baboon plasma, high-performance liquid chromatography (HPLC) metabolic profiles showed three major radiometabolites accounting for 85% and 89% of total radioactivity at 120 minutes after injection, respectively. Rat microsomal incubations and analyses by liquid chromatography–mass spectrometry (LC-MS) identified seven metabolites, characterized as O-deethyl, hydroxyl, and N-deethyl derivatives of nonradioactive DPA-714, two of them having the same retention times than those detected in rat and baboon plasma. The third plasma radiometabolite was suggested to be a carboxylic acid compound that accounted for 15% of the rat brain radioactivity. O-deethylation led to a nonradioactive compound and [F] fluoroacetic acid. Human CYP3A4 and CYP2D6 were shown to be involved in the oxidation of the radioligand. Finally an easy, rapid, and accurate method—indispensable for PET quantitative clinical studies—for quantifying [F]DPA-714 by solid-phase extraction was developed. In vivo, an extensive metabolism of [F]DPA-714 was observed in rats and baboons, identified as [F]deethyl, [F]hydroxyl, and [F]carboxylic acid derivatives of [F]DPA-714. The main route of excretion of the unchanged radioligand in baboons was hepatobiliary while that of radiometabolites was the urinary system.
Delft University of Technology Non-linear finite element analyses applicable for the design of large reinforced concrete structures

In order to make non-linear finite element analyses applicable during assessments of the ultimate load capacity or the structural reliability of large reinforced concrete structures, there is need for an efficient solution strategy with a low modelling uncertainty. A solution strategy comprises choices regarding force equilibrium, kinematic compatibility and constitutive relations. This contribution demonstrates four important steps in the process of developing a proper solution strategy: 1) definition, 2) verification by numerical experiments, 3) validation by benchmark analyses and 4) demonstration of applicability. A complete solution strategy is presented in detail, including a fully triaxial material model for concrete, which was adapted to facilitate its implementation in a standard finite element software. Insignificant sensitivity to finite element discretization, load step size, iteration method and convergence tolerance were found by numerical experiments. A low modelling uncertainty, denoted by the ratio of experimental to predicted capacity, was found by comparing the results from a range of experiments to results from non-linear finite element predictions. The applicability to large reinforced concrete structures is demonstrated by an analysis of an offshore concrete shell structure.