Miracle-dz/UniFAR-FTUs huggingface dataset:
Benefits of Tai Chi Exercise Among Adults With Chronic Heart Failure

Background Exercise-based cardiac rehabilitation is safe and effective for adults with chronic heart failure (CHF), yet services are greatly underutilized. However, tai chi is a popular and safe form of exercise among older adults with chronic health conditions. Objective A systematic review and meta-analysis was conducted to examine the benefits of tai chi exercise among persons with CHF. Methods An electronic literature search of 10 databases (Allied and Complementary Medicine Database, Cumulative Index to Nursing and Allied Health Literature, Embase, OpenGrey, PsycARTICLES, PsycINFO, PubMed, Scopus, SPORTDiscus, and Web of Science) was conducted from January 1, 2004, to August 1, 2019. Clinical trials that examined tai chi exercise, were published in English or German languages, and conducted among participants with CHF were included. Comprehensive Meta-Analysis version 2.0 software (Biostat, Inc) was used to calculate effect sizes (ie, Hedges g) and 95% confidence intervals using random effects models. Results A total of 6 studies met the inclusion criteria, enrolling 229 participants (mean age, 68 years; 28% women; mean ejection fraction = 37%). At least 3 studies reported outcomes for exercise capacity (n = 5 studies), quality of life (n = 5 studies), depression (n = 4 studies), and b-type natriuretic peptide (n = 4 studies), allowing for meta-analysis. Compared with controls, tai chi participants had significantly better exercise capacity (g = 0.353; P = .026, I2 = 32.72%), improved quality of life (g = 0.617; P = .000, I2 = 0%), with less depression (g = 0.627; P = .000, I2 = 0%), and decreased b-type natriuretic peptide expression (g = 0.333; P = .016, I2 = 0%). Conclusion Tai chi can be easily integrated into existing cardiac rehabilitation programs. Further research is needed with rigorous study designs and larger samples before widespread recommendations can be made.
Phenylalkanoid Glycosides (Non-Salicinoids) from Wood Chips of Salix triandra × dasyclados Hybrid Willow

Salix triandra (almond leaved willow) is an established crop, grown in coppicing regimes for basket-making materials. It is known as a source of non-salicinoid phenolic glycosides, such as triandrin and salidroside. A spontaneous natural hybrid of S. triandra and S. dasyclados was subjected to metabolite profiling by high resolution LC-MS, and 22 phenolic glycosides, including 18 that are new to the Salicaceae, were identified. Structures were determined by HPLC isolation and NMR methods. The hybridisation process has introduced novel chemistry into the Salix phenolic glycoside palette, in particular, the ability to generate disaccharide conjugates where the glycosyl group is further extended by a range of sugars, including apiose, rhamnose, xylose, and arabinose. Also of note is the appearance of chavicol derivatives, also not previously seen in Salix spp. The work demonstrates the plasticity of the phenolic glycoside biosynthetic pathway, and the potential to improve established crops such as S. triandra and S. dasyclados, via high-value metabolites, for both basketry and bioenergy markets.
Variations in Values of State, Response Entropy and Haemodynamic Parameters Associated with Development of Different Epileptiform Patterns during Volatile Induction of General Anaesthesia with Two Different Anaesthetic Regimens Using Sevoflurane in Comparison with Intravenous Induct: A Comparative S

Background and Objectives: Raw electroencephalographic (EEG) signals are rarely used to monitor the depth of volatile induction of general anaesthesia (VIGA) with sevoflurane, even though EEG-based indices may show aberrant values. We aimed to identify whether response (RE) and state entropy (SE) variations reliably reflect the actual depth of general anaesthesia in the presence of different types of epileptiform patterns (EPs) in EEGs during induction of general anaesthesia. Materials and Methods: A randomized, prospective clinical study was performed with 60 patients receiving VIGA using sevoflurane with the increasing concentrations (group VIMA) or the vital capacity (group VCRII) technique or an intravenous single dose of propofol (group PROP). Facial electromyography (fEMG), fraction of inspired sevoflurane (FiAA), fraction of expired sevoflurane (FeAA), minimal alveolar concentration (MAC) of sevoflurane, RE and SE, and standard electroencephalographic evaluations were performed in these patients. Results: In contrast to periodic epileptiform discharges, erroneous SE and RE values in the patients’ EEGs were associated with the presence of polyspikes (PS) and rhythmic polyspikes (PSR), which were more likely to indicate toxic depth rather than false emergence from anaesthesia with no changes in the FiAA, FeAA, and MAC of sevoflurane. Conclusion: Calculated RE and SE values may be misleading during VIGA when EPs are present in patients’ EEGs. During VIGA with sevoflurane, we recommend monitoring raw EEG data in scientific studies to correlate it with potentially erroneous RE and SE values and the end-tidal concentration of sevoflurane in everyday clinical practice, when monitoring raw EEG is not available, because they can mislead anaesthesiologists to reduce sevoflurane levels in the ventilation gas and result in unintentional true emergence from anaesthesia. Further studies are required to investigate the behaviour of EEG-based indices during rapid changes in sevoflurane concentrations at different stages of VIGA and the influence of polyspikes and rhythmic polyspikes on the transformation of EEG signals into a digital form.
Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

Chitosan (CS) has gained particular attention in biomedical applications due to its biocompatibility, antibacterial feature, and biodegradability. Hence, many studies have focused on the manufacturing of CS films, scaffolds, particulate, and inks via different production methods. Nowadays, with the possibility of the precise adjustment of porosity size and shape, fiber size, suitable interconnectivity of pores, and creation of patient-specific constructs, 3D printing has overcome the limitations of many traditional manufacturing methods. Therefore, the fabrication of 3D printed CS scaffolds can lead to promising advances in tissue engineering and regenerative medicine. A review of additive manufacturing types, CS-based printed constructs, their usages as biomaterials, advantages, and drawbacks can open doors to optimize CS-based constructions for biomedical applications. The latest technological issues and upcoming capabilities of 3D printing with CS-based biopolymers for different applications are also discussed. This review article will act as a roadmap aiming to investigate chitosan as a new feedstock concerning various 3D printing approaches which may be employed in biomedical fields. In fact, the combination of 3D printing and CS-based biopolymers is extremely appealing particularly with regard to certain clinical purposes. Complications of 3D printing coupled with the challenges associated with materials should be recognized to help make this method feasible for wider clinical requirements. This strategy is currently gaining substantial attention in terms of several industrial biomedical products. In this review, the key 3D printing approaches along with revealing historical background are initially presented, and ultimately, the applications of different 3D printing techniques for fabricating chitosan constructs will be discussed. The recognition of essential complications and technical problems related to numerous 3D printing techniques and CS-based biopolymer choices according to clinical requirements is crucial. A comprehensive investigation will be required to encounter those challenges and to completely understand the possibilities of 3D printing in the foreseeable future.
Using e-Health in the physical therapeutic care process for patients with temporomandibular disorders: a qualitative study on the perspective of physical therapists and patients

Abstract Background Treatment of temporomandibular disorder (TMD) currently consists of a combination of noninvasive therapies and may be supported by e-Health. It is, however, unclear if physical therapists and patients are positive towards the use of e-Health. Purpose To assess the needs, facilitators and barriers of the use of an e-Health application from the perspective of both orofacial physical therapists and patients with TMD. Methods A descriptive qualitative study was performed. Eleven physical therapists and nine patients with TMD were interviewed using a topic guide. Thematic analysis was applied, and findings were ordered according to four themes: acceptance of e-Health, expected utility, usability and convenience. Results Physical therapists identified the need for e-Health as a supporting application to send questionnaires, animated exercises and evaluation tools. Key facilitators for both physical therapists and patients for implementing e-Health included the increase in self-efficacy, support of data collection and personalization of the application. Key barriers are the increase of screen time, the loss of personal contact, not up-to-date information and poor design of the application. Conclusions Physical therapists and patients with TMD are positive towards the use of e-Health, in a blended form with the usual rehabilitation care process for TMD complaints. Implications for rehabilitation The rehabilitation process of temporomandibular complaints may be supported by the use of e-Health applications. Physical therapists and patients with temporomandibular disorders are positive towards the use of e-Health as an addition to the usual care. Especially during the treatment process, there is a need for clear animated videos and reminders for the patients.
Nutrient and Isotopic Dynamics of Litter Decomposition from Different Land Uses in Naturally Restoring Taihang Mountain, North China

Litter decomposition is a prominent pathway for nutrient availability and management in terrestrial ecosystems. An in-situ litter decomposition experiment was carried out for different land use types along an elevation gradient in the Taihang Mountain area restored after heavy forest degradation in the past. Four land use types, i.e., cropland, shrubland, grassland, and forest, selected randomly from a 300–700 m elevation were investigated for the experiment using the litter bag technique. Litter mass loss ranged from 26.9% (forest) to 44.3% (cropland) varying significantly among land use types. The initial litter quality, mainly N and C/N, had a significant effect on the litter loss rate. The interaction of elevation × land use types × time was significant (p < 0.001). Litter nutrient mobility (K > P ≈ N > C) of the decomposing litter was sporadic with substantial stoichiometric effects of C/N, N/P, and C/P. The residual litters were enriched in δ15N and depleted in 13C as compared to the initial litter. Increment of N, P, and 15N values in residual litter indicates that, even in the highly weathered substrate, plant litter plays a crucial role in conserving nutrients. This study is a strong baseline for monitoring the functioning of the Taihang Mountain ecosystem restored after the complete destruction in the early 1990s.
Revolutionary Rebels and the Marxist Paradox

During the Cold War, many rebel movements adopted a revolutionary agenda, with a Marxist or socialist orientation. A large qualitative literature contends that revolutionary rebels were generally high quality rebels, but their overall impact has not been investigated? We find that civil wars where the main rebel group was socialist, tended to be fought as highly demanding irregular wars rather than conventional or symmetric, non-conventional wars, lasting longer and resulting in more fatalities. However, contrary to our expectations, we find that quality did not translate into positive outcomes: socialist rebels tended to be defeated at a higher rate compared to other rebels--hence a “Marxist Paradox. ” To account for it, we argue that the states they challenged had to step up their game. Our analysis suggests the usefulness of incorporating rebel political identity and historicizing the study of civil war; it also points to the state-building dimension of civil wars implicating revolutionary rebels and underlines the implications of their emergence for the way conflict is shaped.
Soil Microbial Community and Its Interaction with Soil Carbon Dynamics Following a Wetland Drying Process in Mu Us Sandy Land

Increasing drought globally is a severe threat to fragile desert wetland ecosystem. It is of significance to study the effects of wetland drying on microbial regulation of soil carbon (C) in the desert. In this study, we examined the impacts of wetland drying on microbial biomass, microbial community (bacteria, fungi) and microbial activity [basal microbial respiration, microbial metabolic quotient (qCO2)]. Relationships of microbial properties with biotic factors [litter, soil organic carbon (SOC), total nitrogen (TN), total phosphorus (TP)], abiotic factors (soil moisture, pH and clay content) and biological processes (basal microbial respiration, qCO2) were also developed. Results showed that the drying of wetland led to a decrease of soil microbial biomass carbon (MBC) content, microbial biomass nitrogen (MBN) content and fungi and bacterial abundance, and an increase of the fungi:bacteria ratio. Wetland drying also led to increased soil basal respiration and increased qCO2, which was attributed to lower soil clay content and litter N concentration. The MBC:SOC ratios were higher under drier soil conditions than under virgin wetland, which was attributed to stronger C conserve ability of fungi than bacteria. The wetland drying process exacerbated soil C loss by strengthening heterotrophic respiration; however, the exact effects of soil microbial community structure on microbial C mineralization were not clear in this study and need further research.
Complex Predicates and Goal PP ' s : Evidence for a Semantic Parameter

By "goal-PP construction" we mean the combination of a simple activity verb (walk) with a prepositional phrase indicating the goal of the activity (to the summit). Our conclusion will be that the semantic interpretation of goal-PP constructions is a point of cross-linguistic variation. Despite the availability of a surface equivalent to (1) in most of the world's languages, the mode of its semantic interpretation varies substantially. Specifically, we propose that the setting of the compounding/complexpredicate parameter (Snyder 1995, in press) strongly affects the mode of interpretation. In languages like English, which permit productive compounding and complex predicates such as resultatives, the goal-PP in (1) is interpreted as a result phrase. For this reason, in English the combination of an activity verb with a goal-PP yields an accomplishment predicate. The cross-linguistic prediction of our account is that a language will permit a goal-PP to convert an activity to an accomplishment only if that language permits fully productive root compounding, and moreover permits the resultative construction. The acquisitional prediction for children learning English is that use of goal-PP constructions will never precede the acquisition of root compounding. Both predictions are tested, and supported, below.
Prevalence and risk factors for Trichomonas vaginalis infection among adults in the U.S., 2013–2014

Objective Trichomonas vaginalis (TV) infection is common, curable, and associated with significant reproductive morbidity and risk for HIV infection. This analysis updates estimates of the prevalence of asymptomatic TV infection, and its associated risk factors, in the non-institutionalized U.S. population. Methods We analyzed data from 4057 individuals who participated in the National Health and Nutrition Examination Survey (NHANES) 2013–2014 data collection cycle. Participant interviews ascertained demographic characteristics, self-reported tobacco use, and sexual history. Self-collected urine specimens from participants aged 18 to 59 years were tested for TV infection using the Gen-Probe Aptima TV assay. Cotinine was assayed from serum to provide a biomarker of recent tobacco exposure. Weighted percentages are provided to account for unequal selection probabilities among participants and adjustments for non-response. Results Our sample included 1942 men (49.2%, 95% Confidence Interval [CI] 48.0–50.5) and 2115 women (50.8%, 95%CI 49.5–52.0). The infection prevalence among men was 0.5% (n = 16; 95%CI 0.2–1.0) and 1.8% (n = 55; 95%CI 1.1–3.1) in women. After controlling for participant characteristics associated with TV infection, females had a 5.2-fold increased odds of being infected compared to men (adjusted odds ratio (aOR) 5.2, 95% CI 2.4–11.4). Non-Hispanic blacks were more likely to be infected compared to non-Hispanic whites (aOR 11.2, 95% CI 4.6–27.2). Individuals below the federal poverty level were more likely to be infected compared to those earning >3 times the federal poverty level (aOR 6.7, 95% CI 1.7–26.6), and active smokers were more likely to be infected compared to participants with no nicotine exposure (aOR 8.7, 95% CI 4.1–18.2). Conclusion Trichomonas vaginalis infection continues to be relatively common, especially in women, smokers, non-Hispanic blacks, and in groups of lower socioeconomic status. Identifying the demographic characteristics of populations in the United States disproportionately affected by TV could impact screening and treatment of this infection in clinical practice. Further research on whether screening and treating for asymptomatic TV infection in high-risk populations improves risk for reproductive morbidity and HIV infection is warranted.
Self-Regulation in Children with Neurodevelopmental Disorders “SR-MRehab: Un Colegio Emocionante”: A Protocol Study

Self-regulation refers to the ability to control and modulate behavior, and it can include both emotional and cognitive modulation. Children with neurodevelopmental disorders may show difficulties in self-regulation. The main objective of this study is to improve self-regulation skills in children between 6 and 11 years of age with neurodevelopmental disorders. Methodology: A randomized controlled trial will be conducted with the use of “SR-MRehab: Un colegio emocionante”, based on a non-immersive virtual reality system where virtual objects can be managed by children in a natural way using their hands. Children will be recruited from several schools of Granada (Spain) and they will be randomly allocated to two groups. An assessment will be conducted before and after the intervention and 24 weeks after the end of the intervention process. The experimental group will receive the intervention using virtual reality. The control group will receive a standard self-regulation program. Both interventions will be performed once a week for a total of 10 sessions. Changes in self-regulation, as well as the acceptability of technology with the use of SR-MRehab, will be evaluated. The results will be published and will provide evidence regarding the use of this type of intervention in children with neurodevelopmental disorders. Trial registration: Registered with code NCT04418921.
Bcl2-Associated X (BAX) Knockout in Mice Resulted in Persistence of Neonatal Testicular Germ Cells (Gonocytes)

During early testicular development, neonatal gonocytes transform into spermatogonial stem cells (SSC), and any untransformed gonocytes are thought to undergo apoptosis. In human cryptorchidism, persisting gonocytes may lead to seminoma. Using Bcl2-associated X knockout (BAXKO) mice, we investigated apoptosis in gonocyte development during mouse minipuberty. Testes from BAXKO, heterozygous (HET), and wild-type (WT) littermates were collected on postnatal days 1, 3, 6, and 9 (n = 6/group), labelled with antibodies against mouse vasa homologue (MVH, germ cell marker) or promyelocytic leukaemia zinc-factor (PLZF, SSC marker) and imaged for cell counting. Total germ cells/tubule, i.e., the number of germ cells on and off the basement membrane (BM), were counted using Image J followed by 2-way ANOVA analysis with Prism. Total PLZF+ germ cells/tubule, PLZF+ germ cells/tubule off BM, total MVH+ germ cells/tubule, and MVH+ germ cells off BM/tubule were significantly higher at day 9 in BAXKO compared to WT and HET mice (p < 0.01). In conclusion, knockout of BAX in mouse leads to gonocytes persisting at the centre of the tubules after minipuberty, which failed to migrate and transform into SSC, indicating the important role of apoptosis is to eliminate undifferentiated gonocytes during transformation. Failed apoptosis in gonocytes may be the cause of malignancy in humans with cryptorchidism.
Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target

Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.
Towards Attention-Based Convolutional Long Short-Term Memory for Travel Time Prediction of Bus Journeys

Travel time prediction is critical for advanced traveler information systems (ATISs), which provides valuable information for enhancing the efficiency and effectiveness of the urban transportation systems. However, in the area of bus trips, existing studies have focused on directly using the structured data to predict travel time for a single bus trip. For state-of-the-art public transportation information systems, a bus journey generally has multiple bus trips. Additionally, due to the lack of study on data fusion, it is even inadequate for the development of underlying intelligent transportation systems. In this paper, we propose a novel framework for a hybrid data-driven travel time prediction model for bus journeys based on open data. We explore a convolutional long short-term memory (ConvLSTM) model with a self-attention mechanism that accurately predicts the running time of each segment of the trips and the waiting time at each station. The model is more robust to capture long-range dependence in time series data as well.
10-039 Innovation , Competition and Incentives for R & D

This paper analyses the relationship between past innovation output, competition, and future innovation input in a dynamic econometric setting. We distinguish two dimensions of competition that correspond to the concepts of product substitutability and entry barriers due to fixed costs. Based on firm-level panel data for Germany and Switzerland we obtain consistent results for both countries. Innovation output in t-1 as measured by the sales share of innovative products is positively related to the degree of product obsolescence in t, and negatively to the degree of substitutability in t in both countries. Further, we find that rapid product obsolescence provides positive incentives for higher – primarily product-oriented – R&D investments in t+1, while high substitutability exerts negative incentives for future R&D investment.