Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigation of the Perceived Coronavirus Threat, E-Health Literacy, and Psychological Well-Being in Turkey

ABSTRACT This study aims to examine the relationship between e-health literacy, psychological well-being, and perceived coronavirus disease threat in people aged 18 and over living in Turkey. Another aim of the study is to reveal whether the participants’ perceptions about the threat of coronavirus disease, e-health literacy, and psychological well-being differ according to various socio-demographic characteristics. Data was collected from 5153 people through a questionnaire created via Google Form on the Internet. The data collection process was carried out on April 22–27, 2020. According to the result of the regression analysis made in line with the data obtained; it was determined that the perceived coronavirus threat explained 4.6% of the total variance on psychological well-being and 2.7% of the total variance on e-health literacy; and finally, e-health literacy explained 18.6% of the total variance on psychological well-being. The study also revealed that the participants’ scores regarding the perceived coronavirus threat show statistically significant differences depending on age, gender, marital status, education level, place of residence, income level, having a chronic disease, regular drug use, smoking use, the degree of information about the coronavirus disease and watching TV programs about the current coronavirus news. As a result of this research, it is thought that individuals should minimize their perception of coronavirus threats by increasing their e-health literacy levels, and thus, their psychological well-being levels should be increased.
Comfort of earplugs: results of a field survey based on the COPROD questionnaire

Abstract Many workers are exposed to noise levels that can cause hearing problems. Earplugs remain a common form of protection for workers exposed to hazardous levels. Their comfort directly affects the effective protection by influencing their consistent and correct use. In order to assess comfort, the COPROD questionnaire was previously developed on the basis of four comfort dimensions: acoustic, physical, functional and psychological. During this field survey, nine earplug models were evaluated by 118 participants over a 6-week period. This paper presents analyses of the collected data and compares three families of earplugs: roll-down foam, premolded and custom moulded. Analyses have shown a better rating of custom moulded earplugs in terms of overall comfort and for all dimensions of comfort. Although premolded earplugs are generally preferred to roll-down foam earplugs, from a statistical point of view, the evaluations of these two families are not significantly different for numerous characteristics. Practitioner Summary: Earplugs comfort conditions the hearing protection of the users. The COPROD questionnaire was developed to jointly evaluate all dimensions of comfort. Nine earplugs models were evaluated by 118 participants during 6 weeks. This paper presents analyses of the collected data.
The retinal and perceived locus of fixation in the human visual system

Due to the dramatic difference in spatial resolution between the central fovea and the surrounding retinal regions, accurate fixation on important objects is critical for humans. It is known that the preferred retinal location (PRL) for fixation of healthy human observers rarely coincides with the retinal location with the highest cone density. It is not currently known, however, whether the PRL is consistent within an observer or is subject to fluctuations and, moreover, whether observers’ subjective fixation location coincides with the PRL. We studied whether the PRL changes between days. We used an adaptive optics scanning laser ophthalmoscope to project a Maltese cross fixation target on an observer's retina and continuously imaged the exact retinal location of the target. We found that observers consistently use the same PRL across days, regardless of how much the PRL is displaced from the cone density peak location. We then showed observers small stimuli near the visual field location on which they fixated, and the observers judged whether or not the stimuli appeared in fixation. Observers’ precision in this task approached that of fixation itself. Observers based their judgment on both the visual scene coordinates and the retinal location of the stimuli. We conclude that the PRL in a normally functioning visual system is fixed, and observers use it as a reference point in judging stimulus locations.
Chaotic Harris Hawks Optimization with Quasi-Reflection-Based Learning: An Application to Enhance CNN Design

The research presented in this manuscript proposes a novel Harris Hawks optimization algorithm with practical application for evolving convolutional neural network architecture to classify various grades of brain tumor using magnetic resonance imaging. The proposed improved Harris Hawks optimization method, which belongs to the group of swarm intelligence metaheuristics, further improves the exploration and exploitation abilities of the basic algorithm by incorporating a chaotic population initialization and local search, along with a replacement strategy based on the quasi-reflection-based learning procedure. The proposed method was first evaluated on 10 recent CEC2019 benchmarks and the achieved results are compared with the ones generated by the basic algorithm, as well as with results of other state-of-the-art approaches that were tested under the same experimental conditions. In subsequent empirical research, the proposed method was adapted and applied for a practical challenge of convolutional neural network design. The evolved network structures were validated against two datasets that contain images of a healthy brain and brain with tumors. The first dataset comprises well-known IXI and cancer imagining archive images, while the second dataset consists of axial T1-weighted brain tumor images, as proposed in one recently published study in the Q1 journal. After performing data augmentation, the first dataset encompasses 8.000 healthy and 8.000 brain tumor images with grades I, II, III, and IV and the second dataset includes 4.908 images with Glioma, Meningioma, and Pituitary, with 1.636 images belonging to each tumor class. The swarm intelligence-driven convolutional neural network approach was evaluated and compared to other, similar methods and achieved a superior performance. The obtained accuracy was over 95% in all conducted experiments. Based on the established results, it is reasonable to conclude that the proposed approach could be used to develop networks that can assist doctors in diagnostics and help in the early detection of brain tumors.
Responsiveness of the Brazilian IdFAI questionnaire in patients with chronic ankle instability

ABSTRACT Purpose This study aimed to determine the responsiveness of the Brazilian version of the Identification of Functional Ankle Instability (IdFAI) questionnaire in students who received an eight-week treatment for chronic ankle instability (CAI). Methods Twenty-five college students (aged 23.12 ± 2.80 years) with CAI, as identified by the IdFAI questionnaire, were recruited. We used distribution and anchor-based methods to assess the responsiveness of the questionnaire, and its ability to determine clinical changes in participants. Eleven anchors were used: Visual Analog Scale for instability (VAS-i); Cumberland Ankle Instability Tool (CAIT); Isometric dorsiflexion, plantar flexion, inversion, and eversion muscle strength measured using a manual dynamometer; Dynamic balance as assessed through the Star Excursion Balance Test (SEBT-Y); Active ankle dorsiflexion range of motion as measured using the weight-bearing lunge test; and Functional performance assessment using three hop tests: single hop, triple crossover hop, and side hop. The distribution-based method used effect size (ES) and standardized response mean (SRM), whereas the anchor-based method used paired t-tests. Both methods allowed the calculation of the minimal important difference (MID). Results The Brazilian IdFAI showed high responsiveness, with a large magnitude of change (ES = 1.34) and a high responsiveness index (SRM = 1.28) when assessed after a treatment for CAI. The IdFAI total score (p < .001) and all the 11 anchors [VAS-i (p < .001); CAIT (p < .001); Isometric dorsiflexion (p < .001), plantar flexion (p < .001), inversion (p < .001), and eversion (p < .001) muscle strength; SEBT-Y (p < .001); Lunge test (p = .002); Single hop (p < .001); triple crossover hop (p < .001); and side hop tests (p < .001)] showed significant differences. The anchor and distribution-based methods demonstrated MID values of 3.72 and 1.49–2.27, respectively. Conclusion The Brazilian IdFAI questionnaire is a patient-reported outcome measure sensitive to clinical changes in individuals with CAI. It can be used as an identification of patients with CAI, and as a parameter to verify clinical changes of clinical trials or therapeutic interventions in the population with CAI.
Enterococcal bloodstream infections in critically ill patients with COVID-19: a case series

Abstract Background An unexpected high prevalence of enterococcal bloodstream infection (BSI) has been observed in critically ill patients with COVID-19 in the intensive care unit (ICU). Materials and methods The primary objective was to describe the characteristics of ICU-acquired enterococcal BSI in critically ill patients with COVID-19. A secondary objective was to exploratorily assess the predictors of 30-day mortality in critically ill COVID-19 patients with ICU-acquired enterococcal BSI. Results During the study period, 223 patients with COVID-19 were admitted to COVID-19-dedicated ICUs in our centre. Overall, 51 episodes of enterococcal BSI, occurring in 43 patients, were registered. 29 (56.9%) and 22 (43.1%) BSI were caused by Enterococcus faecalis and Enterococcus faecium, respectively. The cumulative incidence of ICU-acquired enterococcal BSI was of 229 episodes per 1000 ICU admissions (95% mid-p confidence interval [CI] 172–298). Most patients received an empirical therapy with at least one agent showing in vitro activity against the blood isolate (38/43, 88%). The crude 30-day mortality was 42% (18/43) and 57% (4/7) in the entire series and in patients with vancomycin-resistant E. faecium BSI, respectively. The sequential organ failure assessment (SOFA) score showed an independent association with increased mortality (odds ratio 1.32 per one-point increase, with 95% confidence interval 1.04–1.66, p = .021). Conclusions The cumulative incidence of enterococcal BSI is high in critically ill patients with COVID-19. Our results suggest a crucial role of the severity of the acute clinical conditions, to which both the underlying viral pneumonia and the enterococcal BSI may contribute, in majorly influencing the outcome. KEY MESSAGES The cumulative incidence of enterococcal BSI is high in critically ill patients with COVID-19. The crude 30-day mortality of enterococcal BSI in critically ill patients with COVID-19 may be higher than 40%. There could be a crucial role of the severity of the acute clinical conditions, to which both the underlying viral pneumonia and the enterococcal BSI may contribute, in majorly influencing the outcome.
Caspofungin Inhibits Mixed Biofilms of Candida albicans and Methicillin-Resistant Staphylococcus aureus and Displays Effectiveness in Coinfected Galleria mellonella Larvae

Infections by microorganisms resistant to antimicrobials is a major challenge that leads to high morbidity and mortality rates and increased time and cost with hospitalization. It was estimated that 27 to 56% of bloodstream infections by C. albicans are polymicrobial, with S. aureus being one of the microorganisms commonly coisolated worldwide. ABSTRACT Candida albicans and Staphylococcus aureus are pathogens commonly isolated from bloodstream infections worldwide. While coinfection by both pathogens is associated with mixed biofilms and more severe clinical manifestations, due to the combined expression of virulence and resistance factors, effective treatments remain a challenge. In this study, we evaluated the activity of echinocandins, especially caspofungin, against mixed biofilms of C. albicans and methicillin-resistant (MRSA) or methicillin-susceptible S. aureus (MSSA) and their effectiveness in vivo using the Galleria mellonella coinfection model. Although caspofungin (CAS) and micafungin (MFG) inhibited the mixed biofilm formation, with CAS exhibiting inhibitory activity at lower concentrations, only CAS was active against preformed mixed biofilms. CAS significantly decreased the total biomass of mixed biofilms at concentrations of ≥2 μg/ml, whereas the microbial viability was reduced at high concentrations (32 to 128 μg/ml), leading to fungus and bacterium cell wall disruption and fungal cell enlargement. Notably, CAS (20 or 50 mg/kg of body weight) treatment led to an increased survival and improved outcomes of G. mellonella larvae coinfected with C. albicans and MRSA, since a significant reduction of fungal and bacterial burden in larval tissues was achieved with induction of granuloma formation. Our results reveal that CAS can be a therapeutic option for the treatment of mixed infections caused by C. albicans and S. aureus, supporting additional investigation. IMPORTANCE Infections by microorganisms resistant to antimicrobials is a major challenge that leads to high morbidity and mortality rates and increased time and cost with hospitalization. It was estimated that 27 to 56% of bloodstream infections by C. albicans are polymicrobial, with S. aureus being one of the microorganisms commonly coisolated worldwide. About 80% of infections are associated with biofilms by single or mixed species that can be formed on invasive medical devices, e.g., catheter, and are considered a dissemination source. The increased resistance to antimicrobials in bacterial and fungal cells when they are in biofilms is the most medically relevant behavior that frequently results in therapeutic failure. Although there are several studies evaluating treatments for polymicrobial infections associated or not with biofilms, there is still no consensus on an effective antimicrobial therapy to combat the coinfection by bacteria and fungi.
How general pediatricians learn procedures: implications for training and practice

ABSTRACT The Accreditation Council for Graduate Medical Education (ACGME) requires General Pediatricians (GPeds) to learn thirteen procedures during training. However, GPeds infrequently perform these procedures in practice. We sought to determine:1) how GPeds learned procedures, 2) if GPeds self-reported achieving competence in the required ACGME procedures during training, and 3) if GPeds maintained these skills into practice. We conducted this mixed methods study from 2019–2020. 51 GPeds from central Ohio and the American Board of Pediatrics General Examination Committee were recruited via email or snowball sampling and participated in semi-structured recorded phone interviews probing procedural performance during training and current practice. Participants represented varied geographic regions and clinical settings. We employed Sawyer’s ‘Learn, See, Practice, Prove, Do, Maintain’ mastery learning pedagogical framework as a lens for thematic analysis. Participants did not demonstrate competence in all ACGME required procedures during training, nor sustain procedural skills in practice. Most participants learned procedures through a ‘see one, do one’ apprenticeship model. GPeds reported never being formally assessed on procedural competence during residency. All GPeds referred out at least one procedure. GPeds also believed that skill maintenance was unwarranted for procedures irrelevant to their current practice. GPeds did not sufficiently demonstrate competence in all ACGME required procedures during training, partially suggesting why they infrequently perform some procedures. Alternatively, these required procedures may not be relevant to their practice. Pediatric residency procedures education might consider using mastery learning for practice-specific procedures and surface-level methods (learning without mastery) for other skills.
Measurement of Acceleration Response Functions with Scalable Low-Cost Devices. An Application to the Experimental Modal Analysis

One of the most popular options in the Structural Health Monitoring field is the tracking of the modal parameters, which are estimated through the frequency response functions of the structure, usually in the form of accelerances, which are computed as the ratio between the measured accelerations and the applied forces. This requires the use of devices capable of synchronously recording accelerations at several points of the structure at high sampling rates and the subsequent computational analysis using the recorded data. To this end, this work presents and validates a new scalable acquisition system based on multiple myRIO devices and digital MEMS (Micro-Electro-Mechanical System) accelerometers, intended for modal analysis of large structures. A simple form of this system was presented by the authors in a previous work, showing that a single board with some accelerometers connected to it got to obtain high quality measurements in both time and frequency domains. Now, a larger system composed by several slave boards connected and synchronized to a master one is presented. Delays lower than 100 ns are found between the synchronised channels of the proposed system. For validation purposes, a case study is presented where the devices are deployed on a timber platform to estimate its modal properties, which are compared with the ones provided by a commercial system, based on analog accelerometers, to show that similar results are obtained at a significantly lower cost.
Combined Effects of Cellulose Nanofiber Nucleation and Maleated Polylactic Acid Compatibilization on the Crystallization Kinetic and Mechanical Properties of Polylactic Acid Nanocomposite

This work investigated the combined effects of CNF nucleation (3 wt.%) and PLA-g-MA compatibilization at different loadings (1–4 wt.%) on the crystallization kinetics and mechanical properties of polylactic acid (PLA). A crystallization kinetics study was done through isothermal and non-isothermal crystallization kinetics using differential scanning calorimetry (DSC) analysis. It was shown that PLA-g-MA had some effect on nucleation as exhibited by the value of crystallization half time and crystallization rate of the PLA/PLA-g-MA, which were increased by 180% and 172%, respectively, as compared to neat PLA when isothermally melt crystallized at 100 °C. Nevertheless, the presence of PLA-g-MA in PLA/PLA-g-MA/CNF3 nanocomposites did not improve the crystallization rate compared to that of uncompatibilized PLA/CNF3. Tensile strength was reduced with the increased amount of PLA-g-MA. Contrarily, Young’s modulus values showed drastic increment compared to the neat PLA, showing that the addition of the PLA-g-MA contributed to the rigidity of the PLA nanocomposites. Overall, it can be concluded that PLA/CNF nanocomposite has good performance, whereby the addition of PLA-g-MA in PLA/CNF may not be necessary for improving both the crystallization kinetics and tensile strength. The addition of PLA-g-MA may be needed to produce rigid nanocomposites; nevertheless, in this case, the crystallization rate of the material needs to be compromised.
Catechol functionalized ink system and thrombin-free fibrin gel for fabricating cellular constructs with mechanical support and inner micro channels

The development of 3D bio printing technology has contributed to protocols for the repair and regeneration of tissues in recent years. However, it is still a great challenge to fabricate structures that mimic the complexity of native tissue, including both the biomechanics and microscale internal structure. In this study, a catechol functionalized ink system was developed to produce tough and elastic scaffolds with built-in micro channels that simulate the vascular structure. And a skin model was designed to evaluate the cytocompatibility of the scaffolds. The mechanical support stemmed from the double network based on catechol-hyaluronic acid (HACA) and alginate, the micro channels were generated using sacrificial gelatin. HACA/alginate and gelatin were firstly printed using a 3D extrusion printer. Thrombin-free fibrinogen were then mixed with human dermal fibroblasts and introduced to the printed scaffolds to induce gelation. An immortal human keratinocyte cell line was introduced on top of the cellular construct to mimic the full thickness skin structure. The printed scaffolds demonstrated high elasticity and supported the formation of a double-layered cell-laden skin like structure. The results suggest the 3D printing platform developed here provides a platform for skin regeneration and could be explored further to engineer functional skin tissue by incorporation of other types of cells.
A Flexible Single Loop Setup for Water-Borne Transient Electromagnetic Sounding Applications

Water-borne transient electromagnetic (TEM) soundings provide the means necessary to investigate the geometry and electrical properties of rocks and sediments below continental water bodies, such as rivers and lakes. Most water-borne TEM systems deploy separated magnetic transmitter and receiver loop antennas—typically in a central or offset configuration. These systems mostly require separated floating devices with rigid structures for both loop antennas. Here, we present a flexible single-loop TEM system, the light-weight design of which simplifies field procedures. Our system also facilitates the use of different geometries of the loop antenna permitting to adjust the depth of investigation (DOI) and the minimum sounding depth in the field. We measure the turn-off ramp with an oscilloscope and use the DOI to assess the minimum and maximum exploration depth of our single-loop TEM system, respectively. A reduction of the loop-antenna size improves early-time TEM data due to a reduced length of the turn-off ramp, whereas an increase of the loop-antenna size enhances the signal strength at late times, which allows to investigate deeper structures below the lake bed. We illustrate the capabilities of our system with a case study carried out at Lake Langau in Austria. Our results show that our system is capable of reaching a DOI of up to 50 m (with a maximum radius of the circular loop of 11.9 m), while it also resolves the water layer down to a minimum thickness of 6.8 m (when the radius is reduced to 6.2 m).