Miracle-dz/UniFAR-FTUs huggingface dataset:
miR-512-5p suppresses proliferation, migration and invasion, and induces apoptosis in non-small cell lung cancer cells by targeting ETS1

An increasing number of microRNA (miRNA) have been demonstrated to serve as molecular biomarkers for tumor cell progression. miR-512-5p was revealed as oncogenic regulator in several types of cancer. However, whether and how miR-512-5p regulates non-small cell lung cancer (NSCLC) remains unclear. In the present study, the expression of miR-512-5p was detected in NSCLC tissues and cell lines. Then, the proliferation, migration, invasion and apoptosis in NSCLC A549 and H1299 cell lines were detected when miR-512-5p was overexpressed. Furthermore, the underlying mechanism was identified. The level of miR-512-5p was decreased in NSCLC tissues and in NSCLC cells compared with adjacent normal tissues and normal lung tissue cell lines. miR-512-5p mimics inhibited the cell proliferation, migration, invasion and induced apoptosis in A549 and H1299 cells. In addition, a luciferase reporter assay suggested that overexpression of miR-512-5p may decrease the expression of the E26 transformation specific-1 (ETS1) gene; it was subsequently verified that downregulation of the ETS1 gene inhibited cell proliferation and migration and induced cell apoptosis in A549 and H1299 cells, and ETS1 small interfering RNA in the presence of an miR-512-5p inhibitor reversed the effect. The data described in the present study suggest that miR-512-5p may be a tumor suppressor and a potential treatment target in NSCLC.
Assessment of respiratory muscle strength and airflow before and after microimplant-assisted rapid palatal expansion.

OBJECTIVES: To assess alterations in respiratory muscle strength and inspiratory and expiratory peak flow, as well as skeletal and dental changes in patients diagnosed with transverse maxillary deficiency before and after microimplant-assisted rapid maxillary expansion (MARPE). MATERIALS AND METHODS: Twenty patients (13 female and 7 male) were assessed by respiratory tests in three different periods: T0 initial, T1 immediately after expansion, and T2 after 5 months. Tests included: maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP), oral expiratory peak flow, and inspiratory nasal flow. Cone-beam computed tomography measurements were performed in the maxillary arch, nasal cavity, and airway before and immediately after expansion. RESULTS: There was a significant increase in MIP between T0 and T2 and MEP between T0 and T1 ( P<.05). Oral and nasal peak flow increased immediately after and 5 months later, especially in patients with initial signs of airway obstruction ( P<.05). In addition, after expansion there was a significant enlargement of the nasal cavity, alveolar bone, and interdental widths at the premolar and molar region. Molars tipped buccally ( P<.05) but no difference was found in premolar inclination. MARPE increased airway volume significantly. CONCLUSIONS: Skeletal changes promoted by MARPE directly affected airway volume, resulting in a significant improvement in muscle strength and nasal and oral peak flow.
Non-Target Structural Displacement Measurement Using Reference Frame-Based Deepflow

Displacement is crucial for structural health monitoring, although it is very challenging to measure under field conditions. Most existing displacement measurement methods are costly, labor-intensive, and insufficiently accurate for measuring small dynamic displacements. Computer vision (CV)-based methods incorporate optical devices with advanced image processing algorithms to accurately, cost-effectively, and remotely measure structural displacement with easy installation. However, non-target-based CV methods are still limited by insufficient feature points, incorrect feature point detection, occlusion, and drift induced by tracking error accumulation. This paper presents a reference frame-based Deepflow algorithm integrated with masking and signal filtering for non-target-based displacement measurements. The proposed method allows the user to select points of interest for images with a low gradient for displacement tracking and directly calculate displacement without drift accumulated by measurement error. The proposed method is experimentally validated on a cantilevered beam under ambient and occluded test conditions. The accuracy of the proposed method is compared with that of a reference laser displacement sensor for validation. The significant advantage of the proposed method is its flexibility in extracting structural displacement in any region on structures that do not have distinct natural features.
A randomized waitlist-controlled trial comparing detached mindfulness and cognitive restructuring in obsessive-compulsive disorder

Objective Whereas research has demonstrated the efficacy of cognitive restructuring (CR) for obsessive-compulsive disorder (OCD), little is known about the efficacy of specific metacognitive interventions such as detached mindfulness (DM). Therefore, this study compared the efficacy of CR and DM as stand-alone interventions. Design We conducted a randomized waitlist-controlled trial. n = 43 participants were randomly assigned to either DM or CR. Out of those participants, n = 21 participants had been previously assigned to a two-week waitlist condition. Materials and methods In both conditions, treatment comprised four double sessions within two weeks. Assessment took place at baseline (Pre1), after treatment (Post) and four weeks after the end of treatment (FU). There was a second baseline assessment (Pre2) in the waitlist group. Independent evaluators were blinded concerning the active condition. Adherence and competence ratings for the two therapists were obtained from an independent rater. Results 40 patients completed the treatment. Two patients dropped out because of exacerbated depression. There were no further adverse events. Both CR and DM were shown to be superior to waitlist and equally effective at reducing OCD symptoms from pre to post assessment as measured with the Y-BOCS (CR: d = 1.67, DM: d = 1.55). In each of the two treatment conditions, eight patients (40%) exhibited a clinical significant change at post assessment. Conclusions The results of this clinical trial suggest the potential efficacy of DM as a stand-alone intervention for OCD, however, our findings need to be interpreted with caution. Results indicate that both CR and DM should be considered as possible alternative treatments for OCD, whereas the working mechanisms of DM have yet to be elucidated.
Social norms and child marriage in Cameroon: An application of the theory of normative spectrum

ABSTRACT This paper reports on a qualitative study on social norms and child marriage in rural Cameroon, a country with high prevalence of child marriage but largely ignored in the literature. Study participants (n = 80) were men and women from four different ethnic groups living in four rural villages (two in the Far-North, two in the East). With the assistance of four local interviewers, we conducted 16 semi-structured focus groups to understand how existing social norms contributed to child marriage in participants’ communities. We found great variety in the influence of social norms on people's health-related practices: across these four communities, social norms made compliance with the child marriage practice (respectively) possible, tolerated, appropriate, and obligatory. Effective health promotion interventions should be grounded within sound theoretical understandings of the varying influence of social norms. Using data on child marriage, this paper offers a case study of how that understanding can be developed.
An Energy Efficient Synchronization Protocol for Target Tracking in Wireless Sensor Array Networks

Time synchronization is an important middleware function that supports the Quality of Service (QoS) of systems in wireless sensor array networks. Instead of providing high synchronization accuracy for all application scenarios, we argue that synchronization protocols should be application specific. In this paper, we exploit the synchronization requirements of target-tracking systems in wireless sensor array networks and propose an energy-efficient Sensor Array Synchronization Protocol (SASP), which provides the required synchronization accuracy to guarantee the QoS. Specifically, when no target appears, to guarantee system lifetime, coarse synchronization is achieved with little overhead by piggybacking time information onto periodical network maintenance packets. Once targets appear, SASP achieves high inter-array and relatively higher intra-array synchronization accuracy rather than the traditional network-wide high accuracy on average. In this way, it guarantees reliable communication and accurate data fusion, while reducing energy consumption. Theoretical analysis and extensive evaluations show the effectiveness of the proposed protocol.
Validation of miRNA prognostic significance in stage II colorectal cancer

Background: Advances in early detection and treatment of colorectal cancer (CRC) has seen marked improvements in recent years. However, it is still the third leading cause of cancer-related deaths worldwide. Although there are studies reporting the significance of miRNAs in stage II colorectal cancer, there is no known comprehensive study utilising collective data from multiple published studies. Thus, this study will focus on performing a systematic review and meta-analysis using published data to identify and underline multiple miRNA targets, with regard to disease prognosis in stage II CRC patients. Methods: The systematic review will be reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, 2015 statement. The required articles will be obtained via a search of bibliographical databases such as Cochrane Library, EMBASE, MEDLINE, PubMed, and Web of Science. A set of keywords in multiple permutations will be used for the search. The reference lists of included studies will also be manually searched to further increase the robustness of the search results. The systematic review will primarily be done via a literary synthesis. Results: Quantitative data synthesis will be based on estimated effect across the studies with forest plots generated to observe pooled outcome measures. A fixed or random-effect model of meta-analysis will be used depending upon the heterogeneity observed between studies. Subgroup analysis will be carried out depending on the availability of sufficient clinical data. Conclusion: Based on the systematic review and meta-analysis results of this study, the possible miRNAs could be predicted toward the prognosis of stage II colorectal cancer, and specific miRNAs may perhaps be considered as a biomarker and therapeutic target for this malignancy.
Bulge plus disc and Sérsic decomposition catalogues for 16 908 galaxies in the SDSS Stripe 82 co-adds: a detailed study of theugrizstructural measurements

Quantitative characterization of galaxy morphology is vital in enabling comparison of observations to predictions from galaxy formation theory. However, without significant overlap between the observational footprints of deep and shallow galaxy surveys, the extent to which structural measurements for large galaxy samples are robust to image quality (e.g., depth, spatial resolution) cannot be established. Deep images from the Sloan Digital Sky Survey (SDSS) Stripe 82 co-adds provide a unique solution to this problem - offering $1.6-1.8$ magnitudes improvement in depth with respect to SDSS Legacy images. Having similar spatial resolution to Legacy, the co-adds make it possible to examine the sensitivity of parametric morphologies to depth alone. Using the Gim2D surface-brightness decomposition software, we provide public morphology catalogs for 16,908 galaxies in the Stripe 82 $ugriz$ co-adds. Our methods and selection are completely consistent with the Simard et al. (2011) and Mendel et al. (2014) photometric decompositions. We rigorously compare measurements in the deep and shallow images. We find no systematics in total magnitudes and sizes except for faint galaxies in the $u$-band and the brightest galaxies in each band. However, characterization of bulge-to-total fractions is significantly improved in the deep images. Furthermore, statistics used to determine whether single-Sersic or two-component (e.g., bulge+disc) models are required become more bimodal in the deep images. Lastly, we show that asymmetries are enhanced in the deep images and that the enhancement is positively correlated with the asymmetries measured in Legacy images.
Sacubitril/valsartan effect on left ventricular remodeling: the case of a super-responder

Abstract Sacubitril/valsartan has been shown to improve clinical outcomes in patients with heart failure and reduced ejection fraction (HFrEF), but its effects on left ventricular (LV) systolic function and reverse remodeling parameters remain to be established. We hereby describe the case of a 41 year old man with HFrEF and severe reduction of left ventricular ejection fraction (LVEF). The patient was first treated with triple HF therapy (beta-blocker, angiotensin converting enzyme inhibitor and mineralocorticoid antagonist), but after three months he was still symptomatic and with an LVEF firmly low. In consideration of poor response to therapy, we switched angiotensin converting enzyme inhibitor to sacubitril/valsartan to the maximum tolerated dose (49/51 mg bid) with a marked improvement in LV systolic function and reduction in LV volumes at follow-up. In light of the almost normalized LVEF the patient was also removed from the list for the implantation of a cardiac resynchronization therapy defibrillator. In conclusion, our case showed a strong beneficial effect of sacubitril/valsartan on reverse remodeling and LVEF beyond the benefits of concomitant optimal medical therapy. This result is particular noteworthy because it was obtained although the patient wasn’t able to reach the full dose of the drug. Physicians should always consider this drug effect when more demanding therapeutic strategies are needed for their HF patients.
Astaxanthin inhibits proliferation and induces apoptosis of LX-2 cells by regulating the miR-29b/Bcl-2 pathway

The aim of the present study was to investigate the role of microRNAs (miRNAs/miRs) in the anti-fibrotic effect of astaxanthin (AST), using the human hepatic stellate cell (HSC) line LX-2 as the research model. LX-2 cells were treated with various concentrations of AST (10, 20 and 40 µM) for 24 or 48 h. miR-29b was selected based on existing literature, and its targeting gene B cell lymphoma (Bcl)-2 was predicted by TargetScan and miRanda databases for further analysis. Interactions between miR-29b and Bcl-2 in the AST treated LX-2 cells were evaluated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. MTT analysis was used to analyze cell viability. Overexpression of miR-29b decreased the expression of Bcl-2 in AST-treated LX-2 cells, and silencing of it had the opposite effect. Additionally, Annexin V-fluorescein isothiocyanate/propidium iodide double staining and flow cytometry were used to evaluate the cell apoptosis, and overexpression of miR-29b increased cell apoptosis rates in AST-treated LX-2 cells; however, silencing of it had the opposite effect. RT-qPCR and western blotting demonstrated that AST induced LX-2 cells apoptosis which may be by regulating miR-29b, as indicated by inhibited Bcl-2 expression levels and elevated Bax and Caspase-3 expression levels. These results highlight an important role of miR-29b in the AST modulating LX-2 cells proliferation and apoptosis and implicate a potential mechanism of miR-29b and AST preventing liver fibrosis.
High blood alcohol concentration associated with traumatic brain injury among traffic injury patients during New Year festivals in Thailand

Abstract Objective: Road traffic injury (RTI) is one of the most significant public health problems in Thailand, especially during New Year and Songkran (Thai traditional New Year) holidays, which have the highest traffic density during the entire year. Drunk driving was reported to be one of the leading causes of RTI in Thailand. This study aimed to investigate the prevalence of patients with high blood alcohol concentration (BAC) and the association of BAC and specific organ injury during New Year and Songkran (Thai traditional New Year) holidays. Methods: A cross-sectional study was performed to analyze the database from the Thai Governmental Road Safety Evaluation Project. Patient data on RTIs were collected from 26 main provincial hospitals during the New Year Festival 2003 and 2004 and Songkran Festival in 2003. Patient characteristics, type of organ injured, and BAC levels were mainly analyzed. Results: During those long holidays, 2,642 RTI patients were identified, among whom 1,341 patients had high BAC levels. High BAC levels were associated with motorcycle users, male sex, middle age, teenagers, being riders or drivers, and not using protective devices. Moreover, high BAC levels were associated with brain injury. Conclusion: Excessive alcohol consumption and RTIs occurred on New Year and Songkran Festival in Thailand. Legislation should be strictly used during these long holidays to control driving under the influence of alcohol, particularly among motorcyclists.
Using rapid reviews to strengthen health policy and systems and progress towards universal health coverage

### Summary box As many countries are developing policies addressing universal health coverage (UHC) and the Sustainable Development Goals, there is increasing demand for relevant and contextualised evidence to inform health policy and systems decision-making.1 Policy-makers and health systems managers require valid evidence to support time-sensitive decisions regarding the coverage, quality, efficiency and equity of health systems. There are several health system challenges for which decision-makers require timely evidence, including integrated service delivery models, effective health financing schemes and equitable access to quality health systems interventions (table 1). Progressing towards UHC requires evidence to address a range of questions including the effectiveness of health systems interventions and policies, how and in what settings these interventions work, their cost-effectiveness, as well as the legal, ethical and societal implications of implementing these interventions.2 3 View this table: Table 1 Examples of health …
Redefining the Tonto Group of Grand Canyon and recalibrating the Cambrian time scale

We applied tandem U-Pb dating of detrital zircon (DZ) to redefine the Tonto Group in the Grand Canyon region (Arizona, USA) and to modify the Cambrian time scale. Maximum depositional ages (MDAs) based upon youngest isotope-dilution DZ ages for the Tapeats Sandstone are ≤508.19 ± 0.39 Ma in eastern Grand Canyon, ≤507.68 ± 0.36 Ma in Nevada, and ≤506.64 ± 0.32 Ma in central Arizona. The Sixtymile Formation, locally conformable below the Tapeats Sandstone, has a similar MDA (≤508.6 ± 0.8 Ma) and is here added to the Tonto Group. We combined these precise MDAs with biostratigraphy of trilobite biozones in the Tonto Group. The Tapeats Sandstone is ca. 508–507 Ma; the Bright Angel Formation contains Olenellus, Glossopleura, and Ehmaniella biozones and is ca. 507–502 Ma; and the Muav Formation contains Bolaspidella and Cedaria biozones and is ca. 502–499 Ma. The Frenchman Mountain Dolostone is conformable above the Muav Formation and part of the same transgression; it replaces McKee’s Undifferentiated Dolomite as part of the Tonto Group; it contains the Crepicephalus Biozone and is 498–497 Ma. The Tonto Group thickens east to west, from 250 m to 830 m, due to ∼300 m of westward thickening of carbonates plus ∼300 m of eastward beveling beneath the sub-Devonian disconformity. The trilobite genus Olenellus occurs in western but not eastern Grand Canyon; it has its last appearance datum (LAD) in the Bright Angel Formation ∼45 m above the ≤507.68 Ma horizon. This extinction event is estimated to be ca. 506.5 Ma and is two biozones below the Series 2–Miaolingian Epoch boundary, which we estimate to be ca. 506 Ma. Continued tandem dating of detrital grains in stratigraphic context, combined with trilobite biostratigraphy, offers rich potential to recalibrate the tempo and dynamics of Cambrian Earth systems.
Addressing misconceptions of fast mapping in adults

ABSTRACT Studies of fast mapping (FM) in adults have included both positive results and failures to replicate. I argue that although conflicting studies warrant caution, FM findings are nonetheless promising and intriguing. I separate the issue into distinct questions: whether FM has hippocampal independence, and whether it has unique cognitive consequences. I clarify some misunderstandings and identify limitations that may contribute to failures to find learning from FM in some amnesic patients. Finally, I argue that the array of behavioral findings in healthy adults is consistent with computational and neural models.
Optical Coherence Tomography Angiography of a Pale Optic Disc in Demyelinating Optic Neuritis and Ischemic Optic Neuropathy.

BACKGROUND In the setting of a pale optic disc, distinguishing a previous episode of optic neuritis (ON) from that of nonarteritic anterior ischemic optic neuropathy (NAION) may be difficult on clinical examination. Differences in peripapillary vascular network structures, if present, might be of diagnostic utility. METHODS Thirty-five eyes with demyelinating ON, 33 eyes with NAION, and 81 eyes of normal subjects were imaged with optical coherence tomography angiography (OCT-A) to assess peripapillary vascular density (VD). In addition, OCT was used to measure peripapillary retinal nerve fiber layer (RNFL) thickness. Areas under the receiver operating characteristic curves were used to differentiate ON vs NAION. RESULTS NAION eyes had significantly thinner RNFL thickness than ON eyes. Age-adjusted analysis showed that the peripapillary VD values were significantly reduced in NAION (48.3 ± 7.4%) and ON eyes (54.7 ± 6.1%) compared with healthy controls (62.1 ± 4.6%); pairwise comparisons showed statistically significant differences among all 3 groups. After adjustment for severity of optic nerve injury according to mean RNFL thickness, all VD parameters were not significantly different between ON and NAION eyes. The area under the receiver operating characteristic curves for differentiating NAION from ON eyes was similar for VD (0.75) and RNFL thickness (0.74). CONCLUSIONS Peripapillary VD measurement performs as well as RNFL thickness for distinguishing previous episodes ON and NAION. VD decline might be secondary to RNFL damage and, therefore, VD data have a limited role differentiating these 2 disorders.