Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effectiveness of Virgin Coconut Oil Application on Improving the Skin Integrity of Preterm Infants; Systematic Review and Meta-analysis with Parameters Neonatal Skin Condition Score

Background: Preterm infants have a greater susceptibility to serious infections because their skin barrier has not fully functioned properly. Early birth in preterm infants causes immaturity of the barrier development, in the form of a thinner stratum corneum. Therefore extra care is needed to maintain the integrity of their skin to prevent infection, where the main recommendation is the administration of emollients, such as coconut oil. Virgin coconut oil contains nutrients and lauric acid that are more maintained and higher than coconut oil. Changes in skin integrity can cause extensive skin damage and become risk factors for infection. Erythema or damage to the skin such as erosion, excoriation, or crusting can be an early symptom of life-threatening infection in preterm infants. Assessment of skin integrity can be assessed objectively using the Neonatal Skin Condition Score (NSCS). Virgin coconut oil as an emollient with its antimicrobial activity is expected to allow improvement of the barrier structure of the skin. Aim: The purpose of this study is to review previous studies to provide a systematic summary of the effectiveness of topical coconut oil in improving the skin integrity of premature infants. Methods: Searching the electronic database Pubmed-MEDLINE, Scopus, ProQuest, Cochrane library, ClinicalTrials.gov, and Google Scholar, found five most relevant articles included in the qualitative and two of those five articles included in the meta-analysis. Result: The meta-analysis of the effect of topical VCO compared with control on NSCS values in preterm infants showed the value of heterogeneity test with Tau2=0.04 df=1; p=0.13, I2=55%. The value of the Q statistic was z value = 5.23 (p < 0.001). This shows that the overall administration of topical VCO can significantly improve the value of NSCS on preterm infants. The results of the overall meta-analysis showed that the overall standardized mean difference in NSCS between the intervention group compared to control was -0.93[-1.28 -0.58] (p < 0.001). These results indicate that the overall NSCS value of the intervention group was significantly better than the control group. Conclusion: Data from a systematic review and meta-analysis showed that the application of VCO can provide significantly better results in improving the skin integrity of preterm infants
A Retrospective Study of EPA's Air Toxics Program under the Revised Section 112 Requirements of the Clean Air Act

Under the 1990 Clean Air Act Amendments, the US Environmental Protection Agency (EPA) was required to establish standards limiting air toxics emissions from industrial plants. This paper examines the effect of five of the largest cost rules issued by EPA in the initial round of air toxics rulemaking over the 1995 to 2000 period. Our estimates suggest that plants in the printing and publishing and pulp and paper industries realized important reductions in their air toxics emissions in the period between publication of the final rule and the effective date for compliance with the rule—although the reduction in air toxics emissions by pulp and paper mills falls short of EPA’s ex ante projections. However, our estimates suggest that plants in the other three industries—petroleum refining, pharmaceutical, and wood furniture—achieved little or no additional reduction in air toxics emissions over the compliance period in response to EPA’s air toxics rules. Finally, the paper explores steps that EPA should take in setting up future retrospective analyses.
Automatic Debiased Machine Learning in Presence of Endogeneity†

Recent advances in machine learning literature provide a series of new algorithms that both address endogeneity and can be applied in high-dimensional environments, we call them MLIV. This paper introduces an approach for performing valid asymptotic inference on regular functionals of MLIV estimators. The approach is based on construction of an orthogonal moment function that has a zero derivative with respect to the MLIV estimator. The debiasing is automatic in the sense that it only depends on the form of the identifying moment function but not on the form of the bias correction term. We derive a convergence rate for the penalized GMM estimator of the bias correction term. We also give conditions for root-n consistency and asymptotic normality of the debiased MLIV estimator of the functional of interest. Overall, the approach allows for a large variety of MLIV estimators as along as they satisfy mild convergence rate conditions. We apply our procedure to estimate the conditional demand derivative within the nonparametric demand for differentiated goods framework. Using both simulated and real data, we demonstrate that our debiased estimates have significantly reduced bias and close to the nominal level coverage, while the plug-in estimates perform poorly. †I am very grateful to Amit Gandhi, Xu Cheng, and Karun Adusumilli for their guidance and support, as well as Frank Diebold, Wayne Gao, and participants of the UPenn Econometrics Workshop 2021 and Young Scholars Conference on Machine Learning in Economics and Finance 2021 for insightful comments and suggestions. I would like to thank IRI for making the data available. All estimates and analysis in this paper, based on data provided by IRI, are by the authors and not by IRI. ‡e-mail: bakhitov@sas.upenn. edu 1
Perspectives on Open Science and Scholarly Publishing: a Survey Study Focusing on Early Career Researchers in Europe [version 1; peer review: 2 approved with reservations]

Background: The value of Open Science (OS) for the academic community and society has been becoming more evident recently, especially during the COVID-19 pandemic. Nevertheless, significant challenges regarding its implementation arise that are likely to affect researchers, especially those in early career stages. Hence, monitoring early-career researchers’ views, knowledge, and skills on OS and related policies, is crucial for its advancement. The main aim of this exploratory study was to gain new perspectives regarding the awareness of and attitudes towards OS and related practices having in consideration geographical, economic and research career variables. Methods: The survey was conducted during May-August 2020 as part of a collaboration between Eurodoc and the Open Research Europe project. The data from the survey were analyzed by European region, Gross domestic product, Gross domestic expenditure on research and development as a percentage of gross domestic product, field of study, and career stage. Results: The awareness and positive attitude regarding OS, specifically among early-career researchers, is high in Europe. However, there are significant career stage group differences in views and knowledge about OS. Generally, awareness and positive attitude Open Peer Review
Application of a strain gauge to assess drying stresses in normal and tension wood of Corymbia citriodora

The quantitative evaluation of longitudinal drying strain can provide relevant information for the processing wood and lumber industry, especially with regard to reaction wood in Corymbia , since little has been published. The objective of this work was to evaluate the effect of the steam conditioning and the cooling on the longitudinal drying strain ( LDS ) obtained from a strain gauge, called extensometer, in boards of both normal and tension wood of Corymbia citriodora . Lumbers 30 mm thick were produced and kiln dried at the initial temperature of 40°C, final temperature of 65°C and drying potential of 2,1. The LDS were measured before and after steam conditioning on hot and cold lumbers. It was observed that the conditioning did not reduce the LDS . Hot lumbers showed higher LDS values than the cold lumbers. The LDS values measured in normal, tension and opposite woods were statistically similar, indicating that the type of wood was not an influential factor in the appearance of longitudinal drying stresses. Extensometer proved to be feasible for measuring LDS , allowing its easy and quick quantification.
When Academia Meets Industry: Effective ESP Curriculum Development for Vocational High School Students Delivering Professional Business Presentations

The goal of vocational high schools (VHSs) in Taiwan is to offer VHS students a learning environment that combines professional knowledge with practical skills. However, VHS English education seems to have failed to achieve this goal because English has been taught as a subject rather than as a communication tool. To bridge the gap between learning in schools and demands in the job market, an intensive task-based English for Special Purposes (ITB ESP) program was developed for the purposes of this study to link students' professional knowledge and English skills to the workplace. Twenty-four VHS students were recruited as learning participants to make business PowerPoint (PPT) presentations for workplace purposes. The participants were engaged in making presentations four times (pre-instruction, after-instruction, pre-workplace and post-workplace presentations) and making changes based on instruction and suggestions from different stakeholders (teacher-learners, teachers of business and Applied Foreign Languages (AFL) and workplace supervisors). Both qualitative and quantitative data were analyzed to assess how students' conceptual understanding of and skills related to conducting and delivering PPT presentations evolved over time. The results show that the ITB ESP program had a significant impact on VHS students’ concepts and skills related to making English business presentations. Grounded in the curriculum design process model (Nation & Macalister, 2010), this study identified critical factors contributing to the effectiveness of the program. This study concludes with important implications for ESP curriculum development and collaboration between industry and academia.
APPLYING THE EXTENSION OF TECHNOLOGY ACCEPTANCE MODEL (E-TAM) IN ANALYSING CUSTOMERS’ INTENTION IN USING ONLINE ISLAMIC BANKING IN MALAYSIA

Customers’ intention in using online Islamic banking services has been one of the crucial concerns for every institution, either for banking institutions or eCommerce providers that are rapidly developing nowadays. Therefore, analysing customers’ intention in using online Islamic banking services assists these institutions in finding alternatives to attract new customers more proficiently. This study investigated the determinants affecting customers’ intention in using online Islamic banking services. This study was carried out by conducting a survey through questionnaire distribution to 149 respondents. The factors investigated in this study are Perceived Usefulness, Ease of Use, Enjoyment, Credibility, and Social Norms. This study adopted the relevant variables as they were frequently used in previous studies. The study identified that the customers’ level of intention is high. Perceived Usefulness and Perceived Credibility are having significant influence on customers’ intention. This study also showed that Perceived Credibility is the most significant determinant influencing customers’ intention to use online Islamic banking services. This study contributes to the practitoners on enhanching services to ensure customer feels ease in using them, felt protected and trusted.
University of Groningen Infrared Emitting and Photoconducting Colloidal Silver Chalcogenide Nanocrystal Quantum Dots from a Silylamide-Promoted Synthesis Yarema,

Citation for published version (APA): Yarema, M. , Pichler, S. , Sytnyk, M. , Seyrkammer, R. , Lechner, R. T. , Fritz-Popovski, G. , Jarzab, D. , Szendrei, K. , Resel, R. , Korovyanko, O. , Loi, M. A. , Paris, O. , Hesser, G. , Heiss, W. , & Hesser, G. (2011). Infrared Emitting and Photoconducting Colloidal Silver Chalcogenide Nanocrystal Quantum Dots from a Silylamide-Promoted Synthesis. Acs Nano, 5(5), 3758-3765. https://doi.org/10.1021/nn2001118
Factors involved in DNA replication in Escherichia coli: the dnaA, groE and pcn gene products

An investigation into the mechanism by which over-expression of the groE genes is able to suppress temperature sensitive mutations in the dnaA gene in Escher/ch/a coil has been conducted. The available data would tend to suggest that suppression is due to a specific interaction between the groE and dnaAts gene products. Suppression is allele specific; mutations which map to the centre of the gene are suppressed; those at the ends are not. The specificity of allele suppression is identical to that exhibited by certain mutations in the E.coll rpoB gene. Suppression requires the presence of the mutant DnaA protein; dnaAamb mutants are not suppressed. Using fusions of PdnaA-/acZ it has been shown that excess GroE does not act directly to increase transcription of the dnaA gene. A B-galactosidase-DnaA fusion protein has been constructed and used to raise DnaA antiserum. Induction of this fusion protein at high temperature leads to cell death. It is unclear whether the fusion protein possesses DnaA activity. The DnaA antiserum has been used to show that there are less than 1000 molecules of DnaA protein per cell. While attempting to clone the dnaA gene, a large number of 'partial' high-copy suppressors of dnaAts were isolated (so called because they result in better growth at higher temperature, while not significantly increasing the maximum temperature at which growth is possible). The rpoBC genes appear to fall into this c ata gory. Over-expression of groE in conjunction with certain dnaAts alleles causes cold sensitivity. This is allele specific; all cold sensitive alleles can also be suppressed by groE. The pattern of allele specificity is closely matched by the 'or/C' sensitivity of dnaAts alleles (that is, reduced growth when transformed with an or/C plasmid. Over-expression of groE results in numerous other side effects to the cell. These include; a reduced resistance to the antibiotics nalidixic acid and ampicillin; increased resistance to streptomycin; and abnormal sensitivity to heat shock. An investigation into these effects has been conducted. A plasmid containing groES and a truncated groEL has been constructed. This plasmid is maintained at a low copy number, yet is able to suppress dnaAts mutations with no apparent over-production of GroE. The deletion in the GroEL protein has removed a glycine rich region located at the carboxyl terminus. The significance of this deletion regarding the ability of GroE to suppress dnaAts is discussed, in the
Bandgap Energy of TiO2/M-Curcumin Material (M = Na+, Mg2+, Cu2+)

Bandgap energy (Egap) of TiO2/curcumin as well as TiO2/M-curcumin (M = Na+, Mg2+, Cu2+) was determined. The material was prepared on transparent conductive oxide as TiO2 film. Then, the curcumin and curcumin derivatives were adsorbed on TiO2 surface by immersing the film in solution of the compounds. The diffuse reflectance UV-Vis spectra of the materials were recorded and utilized to calculate the Egap using the Tauc plot method. The calculation gave the Egap of TiO2 of 3.27 eV that lowers after being deposited with curcumin and metal-curcumin compounds. The Egap of TiO2/curcumin was 2.82 eV, while TiO2/Na+-curcumin, TiO2/Mg2+-curcumin, and TiO2/Cu2+-curcumin were 2.36, 3.11, and 2.15 eV, respectively. Curcumin metal complexes, i.e., TiO2/Cu2+-curcumin, showed high molar absorptivity and effectively deposited on the TiO2 lowers the bandgap energy of TiO2 compared to free-curcumin on TiO2.
BTT-4479-EGFR targeted therapy in non-small cell lung cancer

Correspondence: Apar Kishor Ganti Division of Oncology-Hematology, University of Nebraska Medical Center, Omaha, Ne 68198-7680, USA Tel +1 402 559 6210 Fax +1 402 559 6520 email aganti@unmc.edu Abstract: Chemotherapy alone has limited ability to significantly improve survival in non-small lung cancer (NSCLC) beyond what has already been achieved. The epidermal growth factor (EGF) pathway plays a vital role in the pathogenesis and progression of NSCLC. Two classes of drugs inhibit the EGF receptor (EGFR) pathway: small molecules that inhibit the intracellular tyrosine kinase activity of the receptor, and monoclonal antibodies that target the extracellular domain in the ligand-binding region. Cetuximab is a human – mouse chimeric immunoglobulin G1 class monoclonal antibody directed against EGFR. Preclinical studies with cetuximab suggested that there was inhibition of growth of human NSCLC cell lines. Cetuximab is currently the focus of intense investigation in various patient populations with NSCLC. This review focuses on clinical trials of cetuximab in NSCLC and identifies future directions with this agent.
International Journal of Advance Research in Computer Science and Management Studies

This document the widespread use of technology in almost all areas of life has led to a lot of studies in the field of IT acceptance. One of the most widely used models has been Technology acceptance model which has been used widely in understanding Information system acceptance. In order to study the information system acceptance it is imperative to study the evolution of Technology acceptance model (TAM). This paper tries to understand the evolution of TAM and the relevant information related to it by analyzing the available literature. It also concludes that although there is skepticism related to this model, but by far TAM has interested most of the researchers worldwide and is considered to be the most popular model in studying IT acceptance
Effects of a sport-based positive youth development program on youth life skills and entrepreneurial mindsets

Sport-based life skills interventions offer compelling pathways to understanding the role of physical activity and sport on youth psychosocial and other development outcomes. This is because of evidence that shows the benefits of sport programs to health and well-being of youth, and more lately other areas such as academic achievement and various life skills such as teamwork, leadership and goal setting. However, much of the research in this area of youth development is largely descriptive, with limited capacity to infer causal relationships and application across contexts. Therefore, this study examines the effects of a sport-based intervention program on life skills and entrepreneurial mindsets of youth from three African countries (n = 146, average age = 15.9 years, female = 48.6%). Half of the recruited participants were assigned to a three-week life skills intervention program and the remaining half to a sport-only control program. Both groups completed a demographic information questionnaire, Life Skills for Sport Scale and the General Enterprising Tendency v2 test. Two-way mixed ANOVAs showed significant post-intervention changes in life skills for both groups but changes in entrepreneurial mindsets for the intervention group only. This demonstrates the relevance of sport-based interventions to youth development outcomes in different contexts and the transformative potential of youth sport reported in previous studies. The findings have important implications for intentional and targeted delivery of programs to enhance specific youth development outcomes.
Immunogenicity of Pfizer mRNA COVID-19 Vaccination Followed by J&J Adenovirus COVID-19 Vaccination in Two Patients with Chronic Lymphocytic Leukemia

Individuals with chronic lymphocytic leukemia (CLL) have significant immune disfunction, often further disrupted by treatment. While currently available COVID-19 vaccinations are highly effective in immunocompetent individuals, they are often poorly immunogenic in CLL patients. It is important to understand the role a heterologous boost would have in patients who did not respond to the initial two-dose mRNA vaccine series. SARS-CoV-2 specific immune responses, including antibodies and memory B-cells, CD4 and CD8 T-cells were assessed prior to vaccination, as well as postinitial vaccination series and post-third dose in two subjects. One subject seroconverted, had RBD-specific memory B-cells and spike-specific CD4 T-cells while the other did not. Both subjects had a spike-specific CD8 T-cell response after the original mRNA vaccination series that was further boosted after the third dose or remained stable. The results of this study, however small, are especially promising to CLL individuals who did not seroconvert following the initial mRNA vaccination series.
The Interplay of Attachment Styles and Defense Mechanisms on Eating Disorders Risk: Cross-Sectional Observation in the Community Population

Objective Eating Disorders (Eds) are considered a broad group of pathological conditions characterized by dysregulated eating-related behaviors and habits. Attachment styles and defense mechanisms appear to be linked to the development of EDs-related unhealthy behaviors; however, these factors have been seldom investigated jointly. This study aimed at exploring the shared association between attachment styles, defense mechanisms, and EDs-related behaviors; additionally, we aimed at investigating whether defense mechanisms might be potential mediators of the association between attachment and Eds behaviors. Method A community-based sample was recruited (88% females, mean age= 22.33 ± 4.81 years) and underwent a comprehensive evaluation protocol assessing attachment styles, defense mechanisms, and risk of eating disorders. Results Several shared associations between attachment styles, defense mechanisms, and eating disorders scores were found. Additionally, a maladaptive defense style appeared to be a significant mediator of the association between attachment styles and EDs-related symptoms. Conclusions The integrated evaluation of attachment and defense mechanisms could generate a more comprehensive framework of the psychological antecedents related to Eating Disorders, and it could be a beneficial factor involved in therapies.
A self-directed upper limb program during early post-stroke rehabilitation: A qualitative study of the perspective of nurses, therapists and stroke survivors

Introduction This study aimed to explore the perspective of nurses, therapists and stroke survivors on the performance of upper limb self-exercise and use outside therapy during early inpatient stroke rehabilitation. Methods A descriptive qualitative approach was used in focus groups with nurses (n = 21) and therapists (n = 8), as well as in-depth semi-structured interviews with stroke survivors (n = 8) who were undergoing subacute inpatient stroke rehabilitation. Inductive thematic analysis of data was performed according to participant group. Results Nurses and therapists perceived that stroke survivors played a central role in determining the success of a self-directed upper limb program. Nurses perceived that stroke survivors needed a lot of prompting to be motivated to perform self-directed upper limb therapy outside therapy. Therapists perceived that not all stroke survivors would be able to perform self-directed upper limb therapy and deemed it important to consider stroke survivor factors before commencing a program. Although some stroke survivors expressed initial reservations with performing self-practice, many indicated that they would participate in the self-directed upper limb program because they wanted to recover faster. Conclusion A difference between the perspective of nurses/therapists and stroke survivors towards self-directed upper limb performance outside therapy was found. Deeper stroke survivor engagement and a shift in rehabilitation culture to encourage stroke survivor autonomy are important considerations for a self-directed upper limb program. Teamwork amongst healthcare professionals and families is essential to support stroke survivors to participate in a self-directed upper limb program during early inpatient stroke rehabilitation.