Miracle-dz/UniFAR-FTUs huggingface dataset:
SF3B1 mutations in primary and secondary myelofibrosis: Clinical, molecular and prognostic correlates

Myelofibrosis (MF), polycythemia vera (PPV-MF) or essential thrombocythemia (PET-MF), is characterized by a complex molecular architecture, including mutations in driver ( JAK2 , CALR , MPL ) and other myeloid neoplasm associated genes. 1 Mutations of SF3B1 (splicing factor 3B subunit 1), a component of the U2-small nuclear ribonucleoprotein complex, are uncommon in MF and are reported in <10% of cases. 2 Conversely, they are present in >80% of cases of myelodysplastic syndromes (MDS) with ring sidero-blasts (MDS-RS) and in MDS/MPN with RS and thrombocytosis (MDS/MPN-RS-T) representing a disease-defining genetic event. Indeed, a proposal to consider SF3B1 mutated MDS as an individual entity characterized by an overall better prognosis, has been made. 3 In general, the majority of SF3B1 mutations occur within codon 700 resulting in a large-scale downregulation of messenger RNA (mRNA). 4,5 The characteristics of SF3B1 mutations outside this hotspot, and their downstream effects, are largely unclear; in this regard, SF3B1 K666N in MDS patients was recently associated with distinctive RNA splicing profile, clinical features and worse outcomes. 6
Impacto da vegetação nos microclimas urbanos e no conforto térmico em espaços abertos em função das interações solo-vegetação-atmosfera

Este estudo e parte de uma investigacao sobre o impacto da vegetacao nos microclimas urbanos, abaixo do dossel, em funcao das interacoes solo-vegetacao-atmosfera. Esta pesquisa teve como objetivos: (1) quantificar o impacto da vegetacao por meio de medicoes microclimaticas; (2) fazer uso do modelo preditivo ENVI-met 3.1 para simular o efeito microclimatico da vegetacao com diferentes caracteristicas; (3) quantificar o impacto no conforto humano, com a aplicacao do indice de conforto externo TEP -Temperatura Equivalente Percebida. O metodo e indutivo, por meio de medicoes de campo realizadas no Parque Tenente Siqueira Campos (Trianon), na cidade de Sao Paulo, com o registro de dados microclimaticos por duas estacoes meteorologicas dentro do parque e o levantamento de dados de estacoes fixas externas ao parque, alem das variaveis do dossel arboreo e do solo; e dedutivo, apos a calibracao entre dados medidos e simulados pelo modelo ENVI-met 3.1 e simulacoes de um mesmo cenario, variando-se as caracteristicas do dossel. Dois metodos nao destrutivos indiretos foram utilizados para estimar o indice de area foliar (IAF): com o equipamento LAI-2000 e pos-processamento de fotos hemisfericas. Dentre todas as variaveis medidas e simuladas, os valores da temperatura radiante media sao os mais impactados sob o dossel da vegetacao arborea, influenciando diretamente o conforto termico.
EFFECTIVENESS OF MOTOR IMAGERY COMBINED WITH STRUCTURED PROGRESSIVE CIRCUIT CLASS TRAINING ON FUNCTIONAL MOBILITY IN POST-STROKE INDIVIDUALS: A RANDOMIZED CONTROLLED TRIAL

Objective To compare the effect of motor imagery combined with structured progressive circuit class therapy vs health education combined with structured progressive circuit class therapy on dynamic balance, endurance, and functional mobility in post-stroke individuals. Design Randomized controlled trial. Methods A total of 40 post-stroke individuals were randomly assigned to experimental and control groups. The experimental group was trained using motor imagery combined with structured progressive circuit class therapy, while the control group received health education combined with structured progressive circuit class therapy, 3 times a week for 4 weeks with an overall of 12 sessions. Outcomes included the step test for affected and unaffected limbs, the 6-Minute Walk Test, and the Timed Up and Go test. Assessments were performed at baseline, 2 weeks, and 4 weeks after the intervention Results There were significant effects (p < 0.05) of: group on the step test for unaffected limb; of time on all outcomes; and of their interaction effect on the step test for affected limb, 6-Minute Walk Test, and Timed Up and Go test. Inter-group comparison showed significant differences (p < 0.05) in the step test for unaffected limb at 2 weeks after the intervention. At 4 weeks after the intervention, significant differences (p < 0.05) were found in the step test for affected and unaffected limbs and in the Timed Up and Go test. Conclusion Motor imagery combined with structured progressive circuit class therapy was more effective on the step test, 6-Minute Walk Test, and Timed Up and Go test than training with structured progressive circuit class therapy alone. This suggest that that motor imagery should be incorporated into training programmes for restoring dynamic balance, endurance, and functional mobility in post-stroke individuals. LAY ABSTRACT Survival rates after stroke have increased, with the frequency of mobility impairments remaining high. Therefore, a low-cost and effective stroke rehabilitation technique must be developed and its efficacy proved. This study compared the effect of motor imagery combined with structured progressive circuit class therapy vs health education combined with structured progressive circuit class therapy on dynamic balance, endurance, and functional mobility in post-stroke individuals. Outcomes included the step test, 6-Minute Walk Test, and Timed Up and Go test. Significant improvements occurred in all outcomes when training with motor imagery combined with structured progressive circuit class therapy compared with structured progressive circuit class therapy alone. In conclusion, these results suggest that incorporating motor imagery into the post-stroke training programme may result in greater improvement.
Reschedule of Distributed Energy Resources by an Aggregator for Market Participation

Demand response aggregators have been developed and implemented all through the world with more seen in Europe and the United States. The participation of aggregators in energy markets improves the access of small-size resources to these, which enables successful business cases for demand-side flexibility. The present paper proposes aggregator’s assessment of the integration of distributed energy resources in energy markets, which provides an optimized reschedule. An aggregation and remuneration model is proposed by using the k-means and group tariff, respectively. The main objective is to identify the available options for the aggregator to define tariff groups for the implementation of demand response. After the first schedule, the distributed energy resources are aggregated into a given number of groups. For each of the new groups, a new tariff is computed and the resources are again scheduled according to the new group tariff. In this way, the impact of implementing the new tariffs is analyzed in order to support a more sustained decision to be taken by the aggregator. A 180-bus network in the case study accommodates 90 consumers, 116 distributed generators, and one supplier.
Hypnotizability and psychopathology of patients with personality disorders

ABSTRACT Assessment of hypnotizability is useful in research and predicting the effects of hypnosis in clinical practice. There are few contemporary scientific reports examining the relationship between hypnotizability and psychopathological personality dimensions. The current study explores the connections between abnormal personality in psychiatric patients and the hypnotizability level. Fifty-five patients with anxiety and personality disorders who previously completed the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) were invited to undergo the Elkins Hypnotizability Scale – Clinical Form (EHS-CF). The hypnotizability scores comprise a normal distribution but shifted toward low scores. Twenty-seven patients were included in the low hypnotizability (LOW) group, and 28 patients in the medium to high (MID-HIGH) group. The number of participants with high scores on the Psychopathic Deviate and Paranoia MMPI-2 clinical scales was significantly higher in the LOW than in the MID-HIGH group. Patterns of associations between hypnotizability and psychopathology differed in the two groups. The results indicate that moderate hypnotizability should be considered a normal trait that has no meaningful relationship with psychopathology, but certain dysfunctional symptoms of personality disorders may entail resistance and a defensive attitude toward the hypnotherapy, resulting in a tendency to obtain lower hypnotizability.
Photodegradation of the pure and formulated scoparone in liquid solutions: kinetics and mechanism

ABSTRACT Scoparone (hereafter SPR) is a prominent candidate of plant-derived acaricide. The photodegradation of the pure SPR was first investigated under different light sources, initial concentrations, pH values, temperatures, organic solvents, aqueous media, and the photolytic characteristics of its formulation in pure water were also studied. The photodegradation rates of pure SPR under different light sources showed the following sequence: 28 W ultraviolet lamp (0.3045 h−1) > 500 W xenon lamp (0.1094 h−1) > 300 W xenon lamp (0.0312 h−1). Under the irradiation of 500 W xenon lamp, the lower initial SPR concentrations, higher pH value, and higher temperatures increased the photodegradation rates of SPR, especially, when the temperature increased higher than 35℃, the degradation rate of SPR increased slowly and maintained at a stable level, the pH and temperatures had small effects on the photodegradation of SPR. The photodegradation rates of pure SPR in organic decreased comparing to in aqueous media. The removal efficiency of 98% SPR technical material (TC) was higher than 5% SPR emulsifiable concentrate (EC) in pure water, indicating that the components present in formulated SPR greatly affected the photodegradation kinetics. Detecting the photoproducts by HPLC/ESI-MS indicated that three main types of reaction including photorearrangement, photohydrolysis, and photooxidation occurred in the photodegradation of SPR at aqueous solution. These results will be helpful for the rational use of SPR and provide a scientific reference for environmental risk evaluation of SPR. GRAPHICAL ABSTRACT
Molecular survey of infectious bronchitis virus on poultry farms in Gifu Prefecture, Japan from 2021 to 2022 by RT-PCR with an enhanced level of detection sensitivity for the S1 gene

Infectious bronchitis virus (IBV) is the causative agent of infectious bronchitis (IB) in chickens. There is a correlation between cross-protection and percentage of similarity between nucleotide sequences encoding the S1 subunit, which is responsible for generating neutralizing and serotype-specific antibodies. Therefore, RT-PCR is commonly used to amplify the IBV-S1 gene following DNA sequencing in order to predict the efficacy of vaccines against IBV strains. We successfully enhanced the sensitivity for detection of the IBV-S1 gene by second PCR after purification of the 1st RT-PCR product. Using that method, we obtained detailed information on the prevalence of IBV on poultry farms in Gifu Prefecture, Japan. The IBV-S1 gene detection method used in the current study will enable accurate information on the prevalence of IBV in Japan to be obtained.
The Effect of Conflicting Public Health Guidance on Smokers’ and Vapers’ E-cigarette Harm Perceptions

Abstract Background E-cigarettes are increasingly being viewed, incorrectly, as more harmful than cigarettes. This may discourage smokers from switching to e-cigarettes. One potential explanation for these increasingly harmful attitudes is conflicting information presented in the media and online, and from public health bodies. Aims and Methods In this prospectively registered online study, we aimed to examine the impact of conflicting public health information on smokers’ and vapers’ e-cigarette harm perceptions. Daily UK smokers who do not vape (n = 334) and daily UK vapers (n = 368) were randomized to receive either: (1) a consistent harm reduction statement from two different public health bodies (Harm Reduction), (2) a consistent negative statement about e-cigarette harms from two different public health bodies (Negative), (3) a harm reduction statement from one public health body and a negative statement from another (Conflict), and (4) a statement of the risks of smoking followed by a harm reduction statement from one public health body and a negative statement from another (Smoking Risk + Conflict). Participants then answered questions regarding their perceptions of e-cigarette harm. Results The Negative condition had the highest e-cigarette harm perceptions, significantly higher than the Smoking Risk + Conflict condition (MD = 5.4, SE = 1.8, p < .016, d = 0.3 [CI 0.73 to 10.04]), which did not differ from the Conflict condition (MD = 1.5, SE = 1.8, p = .836, d = 0.1 [CI −3.14 to 6.17]). The Conflict condition differed from the Harm Reduction condition, where harm perceptions were lowest (MD = 5.4, SE = 1.8, p = .016, d = 0.3 [CI 0.74 to 10.07]). Conclusions These findings are the first to demonstrate that, compared to harm reduction information, conflicting information increases e-cigarette harm perceptions amongst vapers, and smokers who do not vape. Implications This research provides the first empirical evidence that conflicting information increases smokers’ and vapers’ e-cigarette harm perceptions, compared to harm reduction information. This may have a meaningful impact on public health as e-cigarette harm perceptions can influence subsequent smoking and vaping behavior. Conflicting information may dissuade smokers, who have the most to gain from accurate e-cigarette harm perceptions, from switching to e-cigarettes. These findings indicate that public health communications that are consensus-based can lower harm perceptions of e-cigarettes, and have the potential to reduce morbidity and mortality attributable to tobacco smoking.
Menstrual cycle disturbances after COVID-19 vaccination

Introduction: After COVID-19 vaccination, women of reproductive age reported changes in their menstrual cycle. Materials and methods: A retrospective study was carried out after a survey on social networks that included women aged 18–41 years with normal cycles according to International Federation of Gynecology and Obstetrics and who were vaccinated (complete schedule for two doses, except J&J/Janssen or incomplete with a single dose). Women with following conditions were excluded: pregnant or lactating women; history of diseases that cause menstrual irregularities or early menopause: anorexia, bulimia, polycystic ovary syndrome, hypothyroidism, obesity, or low weight; hysterectomized or oophorectomized patients; and high performance athletes. Results: Overall, 950 women completed the survey between July and September 2021. In total, 408 women met the inclusion criteria, and 184 reported the following characteristics: frequency (normal 43.47%, infrequent 25%, and frequent 31.53%), regularity (regular 51.08%, irregular 42.93%, and absent/amenorrhea 5.97%), duration (normal 65.21%, prolonged 26.08%, absent/amenorrhea 8.69%), and volume (heavy 41.84%, light 20.65%, and absent/amenorrhea 6.52%). Conclusions: SARS-CoV-2 infection and COVID-19 vaccination can influence the menstrual cycle and cause alterations.
Enhancing social enterprise sustainability: A value cocreation pathway

Purpose - This paper explores the role of the services marketing concept of value co-creation (VCC) in social enterprise (SE) sustainability. Methodology - The research utilized a case study approach, incorporating a purposefully selected regional SE in the form of an Australian Coffee Roasters Guild, comprising six independent organizations. Semi-structured interviews were employed to capture the perspectives of Guild representatives. Thematic analysis and coding of the data was conducted through the lens of the extant VCC and SE literature. Findings - Findings indicate the theoretical fit and practical application of VCC, offers considerable potential to SEs in their quest for organizational sustainability. Specifically, the study demonstrates the aptness of the VCC DART framework as a means for SEs to facilitate sustainable socio-economic outcomes via effective resource integration as supported by mutually beneficial stakeholder relationships. Originality/value - Theoretically, the study identifies the fit of VCC in the context of SEs, via theory-borrowing. It also extends the VCC DART framework, advancing theoretical insight on the sustainability of SEs. Practically, it offers practitioners and policy-makers a platform to assist development of improved SE sustainability strategies. ; ;
Analysis of defensive playing styles in the professional Chinese Football Super League

ABSTRACT Aim Describing and measuring different team styles of play during matches is a key step towards a more predictive and prescriptive performance analysis. The current study aimed to identify and measure different defensive playing styles associated with technical-tactical and physical performance indicators in professional football via Principal Component Analysis (PCA). Methods The sample comprised all 240 matches played in the Chinese Football Super League (CSL) during the 2018 season. Results Seventeen key performance indicators (KPIs), 15 defense-related and 2 physical-related were identified from a total of 62 defensive performance indicators, which significantly differed between when teams lost and did not lose (p<0.05, ES=0.03-0.22). Then the PCA model based on 17 KPIs (Kaiser–Meyer–Olkin value being 0.81), outputted 8 factors representing 7 different styles of play (factor 6 and 8 represented one style) and explaining 83.01% of the total variance. Of all styles, defense close to own goal, including clearance, ball gain in the zone 1, deep completion and unsuccessful cross of the opponent, was the most dominant style (31.92% of the total variance). The champion of the league showed better scores in all styles of play, while the last ranked team got the highest score in defense close to the own goal style. Conclusion The study indicated that a team’s defensive style could be defined by specific KPIs, and teams are suggested to attune their styles consciously rather than maintaining a consistent strategy so as to achieve better performance. Moreover, such categorization of defensive styles could be used during scouting and match preparation.
Advanced Microfluidic Vascularized Tissues as Platform for the Study of Human Diseases and Drug Development

The vascular system plays a critical role in human physiology and diseases. It is a complex subject to study using in vitro models due to its dynamic and three-dimensional microenvironment. Microfluidic technology has recently become a popular technology in various biological fields for its advantages in mimicking complex microenvironments to an extent not achievable by more conventional platforms. Microfluidic technologies can reproduce different vascular system-related structures and functions that can be utilized for drug development and human diseases studies. Herein, we first review the relevant structural and functional vascular biology systems of various organ systems and then the fabrication methods to reproduce these vascular districts. We provide a thorough review of the latest achievement in vascular organ-on-chip modeling specific to lung, heart, and the brain microvasculature for drug screening and the study of human disorders.
Sarcopenia Determined by Skeletal Muscle Index Predicts Overall Survival, Disease-free Survival, and Postoperative Complications in Resectable Esophageal Cancer

Background: Sarcopenia has been identified as a prognostic factor among certain types of cancer. In esophageal cancer, patients are at increased risk of malnutrition and sarcopenia, ultimately contributing to poor outcomes. A systematic review was conducted to determine whether sarcopenia, defined by the skeletal muscle index, is predictive of overall survival, disease-free survival, and postoperative complications in resectable esophageal cancer. Materials and Methods: A systematic search of MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines up until January 2021. The primary outcome was overall survival; secondary outcomes included disease-free survival, pulmonary complications, and anastomotic leak. Results: Twenty-one studies (4 prospective; 17 retrospective; 3966 patients) were included. Sarcopenia was present in 1940 (48.1%) patients and was associated with lower overall survival [hazard ratio (HR): 1.56; 95% confidence interval (CI): 1.25–1.95; P<0.00001; I 2=71%] and disease-free survival (HR: 1.73; 95% CI: 1.04–2.87; P=0.03; I 2=51%). A decrease in skeletal muscle index, independent of sarcopenia status, was associated with lower overall survival (HR: 1.81; 95% CI: 1.20–2.73; P=0.005; I 2=92%). Sarcopenia was associated with increased odds of pulmonary complications (odds ratio: 1.86; 95% CI: 1.29–2.66; P=0.0008; I 2=41%) and increased odds of anastomotic leak (odds ratio: 1.46; 95% CI: 1.11–1.93; P=0.008; I 2=0%). Conclusions: Sarcopenia is a predictor of overall survival, disease-free survival, and postoperative complications in patients with resectable esophageal cancer. Studies on the modifiability of sarcopenia in the preoperative period will help determine the utility of nutritional interventions.
Severity of respiratory signs and symptoms and virus profiles in Japanese children with acute respiratory illness

Associations between the severity of respiratory signs and symptoms and the respiratory viruses identified in 214 Japanese children with acute respiratory illness (ARI) enrolled between January and December 2012 were studied. Respiratory rate, wheezing, cyanosis, and the use of accessory muscles were used as indices of respiratory severity and phylogenetic analysis of the viruses identified in these children was performed. Respiratory viruses such as respiratory syncytial virus (RSV), human rhinovirus (HRV), human parainfluenza virus (HPIV), and human metapneumovirus (HMPV) were prevalent, being detected in approximately 70% of the patients (151/214 patients). Co‐detection of viruses occurred in about 9% of patients. RSV was identified more frequently in cases scored as moderate/severe than in those scored as mild (P < 0.05). Severity scores of patients with RSV were significantly higher than those of cases with HPIV. Moreover, severity scores in patients with mild disease and co‐detections were higher than in those in whom only HPIV or adenovirus was detected. Phylogenetic analysis showed that many genotypes of HRV‐A and ‐C with wide genetic divergence were associated with acute respiratory illness (ARI). On the other hand, only a limited number of genotypes of RSV were associated with ARI. HPIV and HMPV were associated with ARI at similar frequencies. These results suggest that different respiratory viruses with unique genetic characteristics can be found in patients with mild to severe ARI.