Miracle-dz/UniFAR-FTUs huggingface dataset:
Concordance of keratoconus in monozygotic twins before and after combined corneal crosslinking/photorefractive keratectomy (Athens Protocol) using Scheimpflug and OCT tomography

Monozygotic twins with keratoconus discordance in CXL/PRK treatment response, despite similar baseline cone morphology and severity, advocates for environmental factors in keratoconus pathogenesis. Purpose: To describe the concordance of keratoconus (KC) expression in 2 pairs of monozygotic twins before and after a combined corneal crosslinking (CXL)/photorefractive keratectomy (PRK) procedure. Setting: Private ambulatory eye surgery unit. Design: Retrospective interventional twin study. Methods: Two pairs of male monozygotic twins with KC were studied retrospectively. Improvement of flattest (K1) and steepest (K2) keratometry, index of height decentration (IHD), and corneal thickness at the thinnest point and corneal epithelial thickness measured by anterior segment optical coherence tomography and Scheimpflug tomography was compared between respective eyes of monozygotic twin siblings 1 to 5 years after the application of combined CXL and topography-guided PRK of part of the refractive error (the Athens Protocol). Results: Significant improvement was noted in all the keratometric indices of all 8 eyes after the combined CXL/PRK procedure. The difference in K1, K2, IHD, corneal thickness at the thinnest point, and corneal epithelial thickness percentage improvement between the right eyes of each pair of twins was statistically significant 1 year and 5 years postoperatively (P < .05). Statistically significant discordance in the aforementioned parameters percentage improvement was similarly observed between the left eyes of each pair of twins (P < .05). Conclusions: Although a genetic predisposition in KC is well documented, the discordance in keratometric indices improvement after a CXL/PRK procedure between respective eyes of monozygotic twins suggests that environmental influences may contribute to the disease expression as well. Variable degree of synergy in a combined CXL/PRK procedure may also explain the aforementioned discordant improvement.
Liquid water path variability in unbroken marine stratocumulus cloud

Liquid water path variability in unbroken marine stratocumulus clouds is examined using a simple adiabatic model and both ground‐based and airborne observations. Observations from FIRE suggest that fluctuations in liquid water path at scales smaller than around 60 km can be modelled reasonably well as a function of fluctuations in cloud‐base height. A simple adiabatic model of cloud liquid water content with a normally distributed cloud base and constant inversion height results in liquid water path distributions that compare favourably with observations. Further, it is shown how cloud‐base height fluctuations can be predicted from the sub‐cloud turbulent fluctuations of temperature, specific humidity and their covariance. The relative importance of these three contributing terms is assessed. Aircraft observations of these fluctuating variables are used to predict the widths of liquid water path distributions observed radiometrically. The observations also suggest that the standard deviation of cloud‐base height and hence liquid water path variability increases with increasing boundary‐layer depth. The model liquid water path distributions could be used to derive plane‐parallel albedo biases and offer a possible framework for future parametrizations of subgrid‐scale variability in general circulation models.
Unitary irreducible representations of the Lorentz group

The unitary irreducible representations of the inhomogeneous, proper Lorentz group are determined, using a prescription given by Wigner, with special emphasis on the case of zero rest mass. The principal results are: (a) the construction of one-component representations for the case of zero mass and discrete spin; (b) the existence of a Foldy-Wouthuysen transformation for zero mass and spin \textonehalf{}; (c) the construction of "position operators" for zero mass and spins \textonehalf{}, 1; (d) the complete synthesis of the Dirac, Majorana, and Maxwell one-particle theories.
Lost characters and lost taxonomists: Coelocarteriidae fam. nov., Poecilosclerida with and without chelae, to accommodate supposed phloeodictyids (Haplosclerida)

ABSTRACT The taxonomic study of Great Amazon Reef System sponges yielded three Oceanapia-like (Phloeodictyidae, Haplosclerida) species of similar gross morphology, two preliminarily identified as O. bartschi and another as Coelocarteria (Poecilosclerida), due to the presence of common palmate isochelae. The remarkable overall similarity of all three species in gross morphology necessitated an integrative assessment of the phylogenetic affinities. A selection of haplosclerid and poecilosclerid sequences (18S and 28S rRNA) was gathered from Genbank and compared to sequences mapped to reference from metagenome of two Oceanapia-like species from the Amazon River mouth, one of which matched O. bartschi. Both Brazilian species clustered with Coelocarteria singaporensis (Singapore). These species nest in the Poecilosclerida, far from Oceanapia (sp. and isodictyiformis) and other haplosclerids (Amphimedon, Petrosia, Siphonodictyon and Xestospongia) but also far from the poecilosclerid Isodictya that is currently classified in the same family as Coelocarteria, the Isodictyidae. Specimens with chelae are named Coelocarteria alcoladoi sp. nov. herein, while those without chelae represent the other two species. One matched Inflatella bartschi (O. bartchi’s holotype, here re-examined), thereby supporting the transfer of this species to Coelocarteria. The other is proposed as C. amadoi sp. nov. and is the second known lipochelous species in this genus. The 28S phylogenies recovered Coelocarteria bartschi comb. nov. (formerly Oceanapia bartschi) in the Poecilosclerida clade that clustered with Coelocarteria spp. , including the type species of this genus, C. singaporensis, with 100% support. Coelocarteria alcoladoi sp. nov., also without chelae, grouped in the same clade, thereby corroborating the classification in this genus. The clade composed of Coelocarteria spp. grouped with Cornulella sp. , suggesting an affinity between these genera. Coelocarteria is currently situated within Isodictyidae and Cornulella in Acarnidae. Isodictya (Isodictyidae) grouped with Amphilectus (Esperiopsidae) with high support and is only distantly related to Coelocarteria. Acarnus (Acarnidae) grouped with Clathria, also with high support, far from Coelocarteria and Cornulella. These results suggest the polyphyletic nature of Isodictyidae and Acarnidae, for which reason we preferred to propose a new, currently monotypic family for Coelocarteria spp. , Coelocarteriidae fam. nov. ZooBank: urn:lsid:zoobank.org:pub:71FDB6FD-4A5F-4180-8DA7-79EA4CB615D1
Emerging Targeted Therapeutic Strategies to Overcome Imatinib Resistance of Gastrointestinal Stromal Tumors

Gastrointestinal stromal tumors (GISTs) are the most common malignant mesenchymal neoplasms of the gastrointestinal tract. The gold standard for the diagnosis of GISTs is morphologic analysis with an immunohistochemical evaluation plus genomic profiling to assess the mutational status of lesions. The majority of GISTs are driven by gain-of-function mutations in the proto-oncogene c-KIT encoding the tyrosine kinase receptor (TKR) known as KIT and in the platelet-derived growth factor-alpha receptor (PDGFRA) genes. Approved therapeutics are orally available as tyrosine kinase inhibitors (TKIs) targeting KIT and/or PDGFRA oncogenic activation. Among these, imatinib has changed the management of patients with unresectable or metastatic GISTs, improving their survival time and delaying disease progression. Nevertheless, the majority of patients with GISTs experience disease progression after 2–3 years of imatinib therapy due to the development of secondary KIT mutations. Today, based on the identification of new driving oncogenic mutations, targeted therapy and precision medicine are regarded as the new frontiers for GISTs. This article reviews the most important mutations in GISTs and highlights their importance in the current understanding and treatment options of GISTs, with an emphasis on the most recent clinical trials.
Modulation of Asymmetric Inner‐Core Convection on Midlevel Ventilation Leading up to the Rapid Intensification of Typhoon Lekima (2019)

This study investigates how the asymmetric inner‐core convection can modulate midlevel ventilation preceding rapid intensification (RI) of sheared tropical cyclones (TC) based on two numerical experiments of Typhoon Lekima (2019) with warm (CTL) and relatively cool (SSTA0) sea surface temperatures (SSTs). The midlevel ventilation is dominated by an inflow layer between heights of 5 and 10 km in the upshear‐left quadrant, while the convective development in the upshear‐left quadrant acts to induce asymmetric midlevel outflow. These outflows, together with the reduced tilt, lessen the strength of midlevel inflow in a quadrant‐mean sense. Due to a slower boundary‐layer recovery of low‐entropy air over cooler SST, convective development in the upshear‐left quadrant in SSTA0 is suppressed, causing stronger midlevel inflows than that in CTL. A backward trajectory analysis initialized near the RI onset of CTL shows that the TC in CTL is less susceptible to the intrusion of midlevel dry air from left‐of‐shear and upshear‐left quadrant due to the weaker upshear‐left midlevel inflow. Moreover, the intruding air parcels in SSTA0 tend to originate farther away from TC center and lower the eyewall equivalent potential temperature more effectively. A column‐integrated moist static energy (MSE) budget reveals a dramatic increase in MSE in inner‐core region associated with the positive changes of horizontal MSE advection radially outward of enhanced convective rainbands preceding RI onset in CTL. In contrast, the MSE increases more slowly in SSTA0 due to the weaker upshear convection, inducing a less favorable thermodynamic conditions that is potentially responsible for a delayed RI onset.
An Examination of Memory Performance in a Fearful Virtual Reality Gaming Context

Background The emotion of fear bears a survival significance enabling animals to be highly vigilant in contexts of uncertainty. Expectedly, not all information available in the environment can be processed. Given that a major goal is to get rid of the source of fear in a fearful situation, the current study therefore hypothesized that information relating to the fear source would be better attended to and recalled than contextual information, which was validated by comparing participants’ recall of different types of information presented in a fearful VR gaming context. Methodology Fifty-four participants were divided into two groups and finished a specific segment of a VR game with different fear levels. Results No significant difference in recall performance on the questions about the appearance of the fear source and the questions about the interaction with the source was observed between the fear and less-fear groups. Yet, contextual information was better recalled than information related to the fear source in both groups. Regardless of whether the contextual information was provided beforehand or not, participants still tended to focus primarily on the environment in the gameplay. Also, the immersiveness of the gameplay was positively related to participants’ fear level. Discussion The tendency of attending to contextual information was speculated to be unconditional, in line with the risk calculation observed in prey when situated in less familiar contexts. It was suggested to further validate the present primarily findings by adopting VR headset with eye-tracking function in future studies. Lastly, an understanding of fear’s effect on memorization might also provide some information for developing future survival horror games.
Does ESG performance promote vitality of capital market? Analysis from the perspective of stock liquidity

Environmental, Social, and Governance (ESG) is changing from a concept to corporate soft power. Can this improve corporate performance in capital markets? There is little literature linking environmental, Social, and Governance performance to stock liquidity. Therefore, It is of urgent theoretical and practical importance to study the impact of environmental, Social, and Governance performance on stock liquidity. Using Chinese A-share listed companies from 2015 to 2020 as a sample to empirically examine the impact of environmental, Social, and Governance performance on stock liquidity and its mechanism. We find that environmental, Social, and Governance performance has a significant positive impact on listed companie’s stock liquidity. This conclusion was validated after conducting a series of robustness tests. Mechanism analysis shows that environmental, Social, and Governance performance can promote stock liquidity by reducing agency costs, increasing the proportion of foreign ownership, and improving corporate reputation. The heterogeneity analysis shows that environmental, Social, and Governance performance in state-owned enterprises, heavily polluting enterprises, and enterprises in areas with low degrees of marketisation has a more significant positive promoting effect on stock liquidity. This study expands the research on environmental, Social, and Governance performance and has implications for promoting the development of environmental, Social, and Governance practices.
Modeling of galactic cosmic rays in the heliosphere

The modulation of galactic cosmic ray (GCR) Carbon in a north-south asymmetrical heliosphere is studied, using a two-dimensional numerical model that contains a solar wind termination shock (TS), a heliosheath, as well as particle drifts and diffusive shock re-acceleration of GCRs. The asymmetry in the geometry of the heliosphere is incorporated in the model by assuming a significant dependence on heliolatitude of the thickness of the heliosheath. As a result, the model allows comparisons of modulation in the north and south hemispheres during both magnetic polarity cycles of the Sun, and from solar minimum to moderate maximum conditions. When comparing the computed spectra between polar angles of 55 (approximating the Voyager 1 direction) and 125 (approximating the Voyager 2 direction), it is found that at kinetic energies E <∼ 1.0 GeV/nuc the effects of the assumed asymmetry in the geometry of the heliosphere on the modulated spectra are insignificant up to 60 AU from the Sun, but become increasingly more significant with larger radial distances to reach a maximum inside the heliosheath. In contrast, with E >∼ 1.0 GeV/nuc, these effects remained insignificant throughout the heliosphere even very close to the heliopause (HP). However, when the enhancement of both polar and radial perpendicular diffusion coefficients off the equatorial plane is assumed to differ from heliographic pole to pole, reflecting different modulation conditions between the two hemispheres, major differences in the computed intensities between the two Voyager directions are obtained throughout the heliosphere. The model is further improved by incorporating new information about the HP location and the relevant heliopause spectrum for GCR Carbon at E < 200 MeV/nuc based on the recent Voyager 1 observations. When comparing the computed solutions at the Earth with ACE observations taken during different solar modulation conditions, it is found that it is possible for the level of modulation at the Earth, when solar activity changes from moderate maximum conditions to solar minimum conditions, to exceed the total modulation between the HP and the Earth during solar minimum periods. In the outer heliosphere, reasonable compatibility with the corresponding Voyager observations is established when drifts are scaled down to zero in the heliosheath in both polarity cycles. The effects of neglecting drifts in the heliosheath are found to be more significant than neglecting the enhancement of polar perpendicular diffusion. Theoretical expressions for the scattering function required for the reduction of the drift coefficient in modulation studies are illustrated and implemented in the numerical model. It is found that when
The Effect of Heat Treatment on a 3D-Printed PLA Polymer’s Mechanical Properties

Three-dimensional printing is a useful and common process in additive manufacturing nowadays. The advantage of additive polymer technology is its rapidity and design freedom. Polymer materials’ mechanical properties depend on the process parameters and the chemical composition of the polymer used. Mechanical properties are very important in product applicability. The mechanical properties of polymers can be enhanced by heat treatment. Additive-manufactured PLA’s mechanical properties and structure can be modified via heat treatment after the 3D printing process. The goal of this research was to test the effect of heat treatment on the mechanical and structural parameters of additive-manufactured PLA. This was achieved via the FDM processing of standard PLA tensile test specimens with longitudinal and vertical printing orientations. After printing, the test specimens were heat-treated at 55 °C, 65 °C and 80 °C for 5 h and after being held at 20 °C for 15 h. The printed and heat-treated specimens were tested using tensile tests and microscopy. Based on the test results, we can conclude that the optimal heat treatment process temperature was 65 °C for 5 h. Under the heat treatment, the test specimens did not show any deformation, the tensile strength increased by 35% and the porosity of the PLA structure decreased.
Mass, luminosity, and line width relations of Galactic molecular clouds

The paper presents an analysis of the cloud sizes, velocity line widths, viral masses, and CO luminosities of 273 Galactic molecular clouds which utilizes the higher resolution Massachusetts-Stony Brook Galactic plane CO survey. It is shown that the molecular clouds are in or near viral equilibrium and are not confined by pressure equilibrium with a warm or hot phase of interstellar matter. Allowance is made for the mass-luminosity law in a cloud model consisting of a large number of optically thick clumps in viral equilibrium each with a thermal internal velocity dispersion; the clouds are optically thin at a fixed velocity along the line of sight. 32 references.
Applications of probe-compensated near-field measurements

The theory of near-field measurements for antenna practitioners is summarized, and the measurement procedures in three coordinate systems, namely rectangular, cylindrical, and spherical are outlined. Specific topics include probe characterization, measurement systems, data reduction, and attendant accuracies. The results of recent studies are also summarized, and some brief remarks on future applications of near-field measurements in the laboratory, the production line, and in field testing and evaluation conclude the paper.
On the Characteristic Height Scales of the Hurricane Boundary Layer

In this study, data from 794 GPS dropsondes deployed by research aircraft in 13 hurricanes are analyzed to study the characteristic height scales of the hurricane boundary layer. The height scales are defined in a variety of ways: the height of the maximum total wind speed, the inflow layer depth, and the mixed layer depth. The height of the maximum wind speed and the inflow layer depth are referred to as the dynamical boundary layer heights, while the mixed layer depth is referred to as the thermodynamical boundary layer height. The data analyses show that there is a clear separation of the thermodynamical and dynamical boundary layer heights. Consistent with previous studies on the boundary layer structure in individual storms, the dynamical boundary layer height is found to decrease with decreasing radius to the storm center. The thermodynamic boundary layer height, which is much shallower than the dynamical boundary layer height, is also found to decrease with decreasing radius to the storm center. The results also suggest that using the traditional critical Richardson number method to determine the boundary layer height may not accurately reproduce the height scale of the hurricane boundary layer. These different height scales reveal the complexity of the hurricane boundary layer structure that should be captured in hurricane model simulations.
Transfer equations for spectral densities of inhomogeneous MHD turbulence

On the basis of the dynamic equations governing the evolution of magneto-hydrodynamic fluctuations expressed in terms of Elsässer variables and of their correlation functions derived by Marsch and Tu, a new set of equations is presented here describing the evolutions of the energy spectrum e± and of the residual energy spectra eR and es of MHD turbulence in an inhomogeneous magnetofluid. The nonlinearities associated with triple correlations in these equations are analysed in detail and evaluated approximately. The resulting energy-transfer functions across wavenumber space are discussed. For e± they are shown to be approximately energy-conserving if the gradients of the flow speed and density are weak. New cascading functions are heuristically determined by an appropriate dimensional analysis and plausible physical arguments, following the standard phenomenology of fluid turbulence. However, for eR the triple correlations do not correspond to an ‘energy’ conserving process, but also represent a nonlinear source term for eR. If this source term can be neglected, the spectrum equations are found to be closed. The problem of dealing with the nonlinear source terms remains to be solved in future investigations.
Compactness Criteria and Measures of Noncompactness in Function Spaces

In [9], R. S. Phillips gave a compactness criterion for subsets of a Banach space X, namely, that if (Ts) is a net of compact operators converging strongly to the identity then a bounded set A ⊆ X is relatively compact if and only if (Ts) converges uniformly on A to the identity. He then used this general result to give concrete compactness criteria in some specific spaces and to investigate compactness of operators. In this paper, we develop these ideas in two directions: firstly, to demonstrate that this method can be used as a unifying tool to derive many classical compactness criteria originally proved using other techniques, and secondly to extend the method from giving a criterion for compactness to giving a generalised measure of noncompactness. The conditions for compactness that result from this approach are not new (though they are possibly given in slightly more generality than can easily be found in the literature), but they all arise from a single, simple, and usually elementary, approach.
Subband processing of finite length signals without border distortions

New equations are derived for the perfect reconstruction of the boundary regions of a subband processed image. These equations are valid for filter banks with an arbitrary number of filters, having arbitrary nonlinear phase, and allowing any border extension method in the analysis section. The filter bank is maximally decimated in a wide sense, i.e., the sum of samples among the subbands is equal to the sum of the image samples, without having to store extended subband signals. >
Assignment of Eigenstructure by Use of Polynomial Matrices

This paper looks at the problem of eigenstructure assignment using output feedback. It solves the eigenvector and eigenvalue assignment for any system with output feedback by characterizing the solutions as polynomial matrices. It presents the concept of an annihilating polynomial matrix product to enable the space containing the eigenvectors to be described by a matrix polynomial. The range of eigenvectors is expressed as a polynomial vector for the achievable closed-loop spectrum, which is also expressed as a diagonal polynomial matrix. Two examples are given to illustrate the technique both for single-input and multi-variable systems.