Miracle-dz/UniFAR-FTUs huggingface dataset:
Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment

2012). Moreover, siRNA-mediated depletion of the Ska Kinetochores mediate chromosome congression by either sliding along the lattice of spindle microtubules or forming end-on attachments to their depolymerizing plus-ends. By following the fates of individual kinetochores as they congress in live cells, we reveal that the Ska complex is required for a distinct substep of the depolymerization-coupled pulling mechanism. Ska depletion increases the frequency of naturally occurring, force-dependent P kinetochore detachment events, while being dispensable for the initial biorientation and movement of chromosomes. In unperturbed cells, these release events are followed by reattachment and successful congression, whereas in Ska-depleted cells, detached kinetochores remain in a futile reattachment/detachment cycle that prevents congression. We further find that Ska is progressively loaded onto bioriented kinetochore pairs as they congress. We thus propose a model in which kinetochores mature through Ska complex recruitment and that this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint.
GG-GAN: A G EOMETRIC G RAPH G ENERATIVE A DVERSARIAL N ETWORK

We study the fundamental problem of graph generation. Specifically, we treat graph generation from a geometric perspective by associating each node with a position in space and then connecting edges in-between based on a similarity function. We then provide new solutions to the key challenges that prevent the widespread application of this classical geometric interpretation: (1) modeling complex relations, (2) modeling isomorphic graphs consistently, and (3) fully exploiting the latent distribution. Our main contribution is dubbed as the geometric graph (GG) generative adversarial network (GAN), which is a Wasserstein GAN that addresses the above challenges. GG-GAN is permutation equivariant and easily scales to generate graphs of tens of thousands of nodes. GG-GAN also strikes a good trade-off between novelty and modeling the distribution statistics, being competitive or surpassing the state-of-the-art methods that are either slower or that are non-equivariant, or that exploit problem-specific knowledge.
NSS_A_307821 1025..1035

1Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany; 2LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany; 3Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Leipzig, Germany; 4Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany Introduction: The relation of electronic media use with sleep quality among preschoolers is a matter of ongoing debate. Longitudinal data are scarce and do not account for sleeping schedules. Methods: We used the German Children’s Sleep Habits Questionnaire to measure parentreported child’s sleep quality; its score is computed by the sum of 34 items defined by a 1–3 level Likert scale (score ranging 34–102), with higher values representing lower sleep quality. A causal mediation analysis of these relations using data from the Ulm SPATZ Health Study in Germany was conducted. Repeated data on electronic media use, book reading, sleep quality, sleep duration, and midpoint of sleep were prospectively collected yearly from ages 4 to 6 years (n=563) during parent’s working days and free days. Results: We observed negative correlations of sleep quality with sleep duration and midpoint of sleep at ages 4–5 (R=−0.21 to −0.10), which attenuated with age 6 years. Sleep duration and midpoint of sleep were strongly positively correlated at all ages (R=0.55–0.95). We observed significant negative associations between total electronic media use and TV/DVD watching, while book reading did neither affect the sleep quality score nor sleep duration or midpoint of sleep. We found little evidence for an indirect negative effect of media use on sleep quality via sleep duration or midpoint of sleep, indicating that media use acts independently on sleep duration, midpoint of sleep, and sleep quality. Non-statistically significant associations of sleep duration and midpoint of sleep on sleep quality indicate that these are independent aspects of sleep adequacy. Evidence for this was stronger during free days. Conclusion: Media use acted on sleep quality through a direct effect in a prospective fashion. Thus, we conclude that electronic media use increases the risk for sleep impairments in German preschoolers, while book reading seems to be a safe and healthy alternative.
A COMPREHENSIVE STUDY ON ERUPTION OF PERMANENT TEETH WITH RELATION TO AGE AND BODY MASS INDEX

: Introduction: Parents consider tooth eruption as an important event in the child’s development, and they have often showed their concern about the timing of eruption of teeth. Eruption time of the teeth and order are essential aspects in treatment planning, mainly when patients require orthodontic treatment, it also plays a pivotal role in forensic dentistry as it can help to find the age of an adolescent. Aims and objective: The basic aim of the study is to assess the eruption of permanent teeth with relation to age and body mass index among local population of Pakistan. Methodology of the study: This cross sectional study was conducted at Punjab Dental Hospital, Lahore during October 2018 to Dec 2018. In this study we selected the participants of aged 10 to 15 years. The data were collected from 100 participants of both genders. Basic information such as educational level, date of birth, place of birth and family history was asked from students or taken from school records. Results: The data were collected from 100 children of both genders. Table 1 shows the descriptive statistics (number of cases, mean, median, standard deviation, and 95% confidence interval of mean) of eruption time of both the jaws and P -value for antagonist teeth (upper and lower corresponding teeth). The minimum mean eruption time was 6.5±1.1 years of right first molar of mandibular jaw (# 46). The maximum eruption time of 11.8 years was for the 2 nd molars of maxillary jaw. Conclusion: It is concluded that there is no significant difference of eruption time between gender in all the studied teeth, except tooth #15, # 25 and #43.
Exploring Gender Distribution in Music Recommender Systems

Music Recommender Systems (mRS) are designed to give personalised and meaningful recommendations of items (i.e. songs, playlists or artists) to a user base, thereby reflecting and further complementing individual users’ specific music preferences. Whilst accuracy metrics have been widely applied to evaluate recommendations in mRS literature, evaluating a user’s item utility from other impact-oriented perspectives, including their potential for discrimination, is still a novel evaluation practice in the music domain. In this work, we centre our attention on a specific phenomenon for which we want to estimate if mRS may exacerbate its impact: gender bias. Our work presents an exploratory study, analyzing the extent to which commonly deployed state of the art Collaborative Filtering (CF) algorithms may act to further increase or decrease artist gender bias. To assess group biases introduced by CF, we deploy a recently proposed metric of bias disparity on two listening event datasets: the LFM-1b dataset, and the earlier constructed Celma’s dataset. Our work traces the causes of disparity to variations in input gender distributions and user-item preferences, highlighting the effect such configurations can have on user’s gender bias after recommendation generation.
On the Capacity of a Cognitive User with Subcarrier Collisions over Rayleigh Fading Channels

—The paper evaluates the capacity of a cognitive user in an orthogonal frequency-division multiplexing-based spectrum sharing communication system that assumes random subcarrier allocation and absence of spectrum sensing information at the secondary (cognitive) user. In the absence of the primary user’s channel occupation information, i.e., no spectrum sensing mechanism is used, the secondary user randomly accesses the subcarriers of the primary network and collides with the primary users’ subcarriers. The capacity of a secondary user under such a random access that assumes subcarrier collisions is evaluated herein paper and used as a performance benchmark to investigate the proposed communication scheme over the Rayleigh fading channel.
Effect of inspiratory muscle trainer on pulmonary function capacity in patients with inhalation injury

Objective: To assess the therapeutic efficacy Inspiratory muscle trainer on pulmonary function capacity in patients with inhalation injury patients. Material and Methods: Forty male patients suffering from inhalation injury were been included in this study, their ages ranged from 20 - 40 years old. These patients were randomly subdivided into two equal groups (twenty patients for each Group (A) = (Exercise Group) This group was composed of 20 patients suffering from inhalation injury, and were represented the group who were received inspiratory muscle training in addition to routine chest physiotherapy in form of (deep breathing, coughing and early ambulation) three times per week for four weeks. Group (B) = (Control Group): This group was composed of 20 patients suffering from inhalation injury, and were represent the control group who were not received inspiratory muscle training but this group were received routine chest physiotherapy alone. Results: According to unpaired t-test and when comparing the two groups (A and B) before treatment, the X' ± SD values were 2.26 ± 0.48 and 2.41 ± 0.58 respectively which indicated no significant improvement (p= 0.000), while comparing the two groups after four weeks of treatment, the X' ± SD values were 3.5 ± 0.46 and 3.07 ± 0.56 respectively which indicated a significant improvement (p= 0.005) in favor of group A (MD= 0.43) and % of improvement was 12.28 %. Conclusion: it that inspiratpry muscle trainer had positive and significant effect on pulmonary function capacity in patient with inhalation injury.
Evaluation of the Diagnostic Value of Calretinin Immunohistochemistry Assay in the Superficial Rectal Biopsy of Children Suspected of Hirschsprung's Disease

Background: Hirschsprung's disease (HD) is the most common cause of colon obstruction in neonates. Lack of calretinin immunohistochemistry (IHC) in colon lamina propria could be associated with aganglionosis. Methods: This cross-sectional retrospective study examined 64 patients suspicious of HD and conducted on collected-demographic data and Hematoxylin/Eosin (H & E) results of the surgical rectal biopsy from the archive of Imam Hossein Hospital, Isfahan, Iran. Calretinin IHC was achieved for all the specimens, and the results of the two methods were compared. The receiver operating characteristic (ROC) chart shows sensitivity changes according to (1-specificity). Moreover, sensitivity, specificity, as well as the positive and negative predictive values (PPV and NPV) of calretinin staining in lamina propria and muscularis mucosa, compared to H & E staining, was calculated in this study. Results: The number of males and females was the same in this study (n=32; 50%). The age of the patients ranged from 1 month to 156 months (13 years). Out of 64 patients, 8 cases were diagnosed with HD, and calretinin staining was negative in 7 patients; moreover, only one case showed weak positive staining. In 56 patients, who were not HD, two patients with negative calretinin staining had a positive H&E staining report. The current study aimed to check the diagnostic value of calretinin IHC in lamina propria of patients suspicious of HD. Compared to H&E staining, which is the routine method in thick wall biopsies, the statistics show that calretinin IHC has a high diagnostic value (P<0.001), sensitivity of 87%, specificity of 96%, PPV of 77%, and NPV of 98%. Conclusion: In conclusion, calretinin IHC utilized in specimens seems superficial and inadequate; moreover, the association with the high specificity percentage (96%) could help physicians with less invasive biopsy methods, such as endoscopic rectal biopsy.
Abolishing virginity

In the last two decades a significant paradigm shift has occurred in the way ecologists describe and study temperate-zone forests. The attempt to define old-growth forests and to measure their structural and functional characteristics has led to substantial progress in the theoretical and practical understanding of these systems (Franklin 1993). A similar shift in terminology and conception has begun in the study of lowland tropical rainforests (= TRF, here defined as Tropical Moist and Tropical Wet forests in the Holdridge system; Holdridge 1979). The purpose of this essay is to encourage this trend. Specifically, I will justify why a shift in conception and terminology is desirable, and suggest a series of readily measured criteria for defining different types of tropical rainforests. I propose that explicitly considering the structural and functional characteristics of forests is an objective and practical method for classifying, comparing and investigating all TRF regardless of their origin. How do ecologists studying tropical rainforests currently describe old-growth tropical rainforests? I searched the last two years offoumal of Tropical Ecology, fournal of Ecology, Ecology and Biotropica and tallied the term first used in all papers on TRF to describe old-growth study sites. In some cases authors merely stated the Holdridge or equivalent classification. In more cases (N = 57), a descriptive term was used to clarify the life zone classification. The most commonly used terms (63%) were 'primary' or 'undisturbed'. Other descriptors included 'mature', 'entirely undisturbed and remote', 'virgin' and 'undisturbed natural'. Only four papers used the term 'old-growth'.
Harmony of Retaining Systems to Various Local Subsoil Conditions â•fi A Case Study

A case study for the utilization of various retaining systems for different subsoil and groundwater conditions encountered within a given site is presented in this paper. The project is known as “BJK Fulya Complex”, covering approximately 160,000 m floor area. It is located at a very prestigious district of the city, therefore maximum underground space gain were desired. As a result nearly 20 m of excavation is planned to be performed partly under groundwater. Due to unique topography and geology of the site, subsoil and groundwater conditions at various faces of the excavation differ considerably. Because of the complicated geology, budget constraints of the project and the high seismicity, it was compulsory to employ various retaining structures such as flexible and rigid retaining systems at various locations within the site including permanent and temporary soil nailing, permanent tie-back cast in-situ reinforced concrete wall and temporary tied-back diaphragm wall consist of soldier cast in-situ piles with jet grout columns in between. Performances of various systems are monitored closely by means of inclinometers. Displacement data and experience obtained from this case study serves an excellent source of data and example for future applications in similar conditions within the city.
Acute Roux Stasis Syndrome and Effective Treatment with Octreotide

Acute Roux Stasis Syndrome (ARSS) is a rare complication after long term surgery that can have life threatening consequences. In this case, the patient was a 58 year-old man who after birth underwent through a distal gastrectomy with Roux en Y - Gastrojejunostomy reconstruction for early born gastric atresia. He presented with signs of severe sepsis and respiratory failure due to aspiration pneumonia. The patient was diagnosed of ARSS no suitable for surgery due to haemodynamic instability. After unsuccessful feeding with nasojejunal enteral nutrition and still persisting bloating and vomiting due to the ARSS, use of compassionate somatostatin analogue (octreotide) was considered, which has been reported as an effective therapy for other complications of long term surgical procedures. Gastric secretions were monitored before and during this treatment. Octreotide therapy resulted in significant reduction of gastric secretions allowing the improvement of the patient. Octreotide could be considered as a conservative management for these patients. tracheostomy). Parenteral nutrition was started on the 5 th day due to non absorbing enteral nutrition and high gastric residual volumes (2000-3000mls/24h). He was covered on antibiotics and Tuberculosis treatment despite not having positive culture results. Mechanical obstruction was ruled out on CT contrast of chest–abdomen and oesophageal gastroduodenoscopy. multidisciplinary with
J OURNAL OF T HEORY AND

Software companies are increasingly offshoring development to countries with high expertise at lower cost. Offshoring involves particular risk areas that, if ignored level may influence the management of these risk areas. Against this backdrop, we present an interpretive case study on how managers perceive and mitigate the risk areas in soft maturity model integration (CMMI) level 5 software company as the client. We f mitigated most of the offshoring risk areas in accordance with the findings of previous rese area of task distribution was a notable exception. In this case, managers perceive and coupling across sites as risk mitigation rather than risk taking. The paper discusses how and why managers perceived and mitigated the risk areas in this way and the implications for theory and practice in software development offshoring.
Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced CMR and Re-Entrant Activity Assessed With ECGI in Human Persistent Atrial Fibrillation

OBJECTIVES This study sought to assess the relationship between ﬁ brosis and re-entrant activity in persistent atrial ﬁ brillation (AF). BACKGROUND The mechanisms involved in sustaining re-entrant activity during AF are poorly understood. METHODS Forty-one patients with persistent AF (age 56 (cid:1) 12 years; 6 women) were evaluated. High-resolution electrocardiographic imaging (ECGI) was performed during AF by using a 252-chest electrode array, and phase mapping was applied to locate re-entrant activity. Sites of high re-entrant activity were de ﬁ ned as re-entrant regions. Late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR) was performed at 1.25 (cid:3) 1.25 (cid:3) 2.5 mm resolution to characterize atrial ﬁ brosis and measure atrial volumes. The relationship between LGE burden and the number of re-entrant
Erzincan’da K ı rk Ya ş ve Üzeri Bireylerde Hipertansiyon S ı kl ı ğ ı , Fark ı ndal ı ğ ı , Tedavisi ve Kontrolü [Frequency, Awareness, Treatment and Control of Hypertension in the over 40 Population

determine the and control of in age who to the 5 care in Erzincan This cross-sectional study with who care at care The data were collected through face-to-face and blood pressures were measured twice. Participants were hypertensive if their average systolic blood pressure was 140 mmHg, or their average diastolic blood pressure was ≥ 90 mmHg, or if they were taking antihypertensive medication. The awareness, treatment and control status of the individuals were also assessed. RESULTS: The overall hypertension frequency was 67.0% (69.6% in women and 63% in men). In the study sample, 77.4% of individuals were aware of their hypertension, all were receiving anti-hypertensive drugs, and 33.9% of patients had their blood pressure under control. Among all hypertensive individuals, the percentage of controlled hypertension (HT) was 26.2%. The frequency of hypertension was associated with age, body mass index (BMI), smoking, level of education, the use of salt, and diabetes. CONCLUSION: These results indicate that the frequency of HT was high, and it was inadequately managed in individuals who came to the primary healthcare centers for any reason and received treatment. Many of the individuals were not aware of their illness. Therefore, it becomes very important and necessary to ensure early diagnosis and control of hypertension and to develop strategies to increase awareness.
Islamic Banking System and Economic Growth: Exploration of D-8 Countries

The aim of this investigation is to look at the effect of the Islamic banking system on the economic growth of D-8 countries as well as their relationship and the causality direction. Annual report time series data were used from 2010–2021. Islamic Banking Financing (IBF) was used as a representation of the Islamic banking sector, while Foreign Direct Investment (FDI), Gross Fixed Capital Formation (GFCF), Gross Domestic Product (GDP), and Trade were used to represent the economic sector. The econometric tools used are the panel unit root test, panel test of cointegration, and the causality test of Granger. The findings showed that, in the short and long run, Islamic banking and economic growth have a positive connection in D-8 countries. Moreover, there is bi-directional causality. That means, there is a two-way causality starting from the growth sector to Islamic banking and Islamic banking to economic growth. It is also discovered that, in the short run, investment (GFCF) and trade activities have an affirmative influence on the development of Islamic banking. Increasing investment formation will thus successfully subsidize the expansion of the Islamic banking segment of D-8 countries. However, the main policy implication is that governments of the D-8 countries can support economic growth by expanding the finance sector through additional liberalization measures. It is recommended to include another variable that is currently not used, such as the quality of the institutions, and moreover, to apply other statistical tools such as ARCH and GARCH to look at profound relationships.
observational study of comparison between laparoscopic retro-rectal vs open pre-peritoneal Ventral hernia repair

Background: Hernias are one of the most common anatomical derangements in men and women and have left an indelible mark throughout most of recorded history. For hundreds of years various surgical and non-surgical treatments were offered to patients suffering from chronic pain, obstruction and strangulation related to their hernias. Materials & Methods: The study was undertaken in tertiary health centre in prospective manner from July 2017 to July 2019 on Laparoscopic retro-rectal versus Open pre-peritoneal ventral hernia repair. Results: In present study, mean age of patients in Laparoscopy group was 45.26 years & in Open group was 48.92 years. 25 patients were males and 15 patients were females in the study. 10 patients were of Umbilical hernia, 3 patients were of Paraumbilical hernia and 2 patients were of Epigastric hernia in Laparoscopy group. While for Open group there were 14, 7 & 4 patients respectively. Swelling in abdomen which disappears on lying down was the main complaint of patients, followed by pain in abdomen. Average BMI of patients in Laparoscopy group was 25 Kg/m2 while in Open group it was 25.33 Kg/m2.
Wind turbine performance decline in Sweden

We show that Swedish wind turbines constructed before 2007 lose 0.15 capacity factor percentage points per year, corresponding to a lifetime energy loss of 6%. A gradual increase of downtime accounts for around one third of the deterioration and worsened efficiency for the remaining. Although the performance loss in Sweden is considerably smaller than previously reported in the UK, it is statistically significant and calls for a revision of the industry practice for wind energy calculations. The study is based on two partly overlapping datasets, comprising 1,100 monthly and 1,300 hourly time series spanning 5–25 years each.