Miracle-dz/UniFAR-FTUs huggingface dataset:
Versatile Role of Prokineticins and Prokineticin Receptors in Neuroinflammation

Prokineticins are a new class of chemokine-like peptides involved in a wide range of biological and pathological activities. In particular, prokineticin 2 (PK2), prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2) play a central role in modulating neuroinflammatory processes. PK2 and PKRs, which are physiologically expressed at very low levels, are strongly upregulated during inflammation and regulate neuronal-glial interaction. PKR2 is mainly overexpressed in neurons, whereas PKR1 and PK2 are mainly overexpressed in astrocytes. Once PK2 is released in inflamed tissue, it is involved in both innate and adaptive responses: it triggers macrophage recruitment, production of pro-inflammatory cytokines, and reduction of anti-inflammatory cytokines. Moreover, it modulates the function of T cells through the activation of PKR1 and directs them towards a pro-inflammatory Th1 phenotype. Since the prokineticin system appears to be upregulated following a series of pathological insults leading to neuroinflammation, we will focus here on the involvement of PK2 and PKRs in those pathologies that have a strong underlying inflammatory component, such as: inflammatory and neuropathic pain, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, stroke, obesity, diabetes, and gastrointestinal inflammation.
Spatiotemporal Variations of Reference Evapotranspiration and Its Determining Climatic Factors in the Taihang Mountains, China

Reference evapotranspiration (ETo) is an effective measure of atmospheric water demand of the land surface. In-depth investigations of the relationship between ETo and primary climatic factors can facilitate the adaptable agriculture and optimize water management, especially in the ecologically fragile Taihang Mountains (THM). This work assessed the spatiotemporal dynamics of ETo and its driving climatic factors from 1973 to 2016 in THM. Results showed: (1) Annual ETo slightly increased during 1973–2016; relative humidity (RH) decreased more slowly, the temperature increased more rapidly, and wind speed (WS) decreased more rapidly at higher elevation than those at lower elevations; (2) two breakpoints occurred in ETo series at 1990 and 1997, and an “evaporation paradox” existed in 1973–1990; (3) ETo at higher elevations had greater sensitivity to changes in RH and lower sensitivity to changes in Tmax and WS. Sensitivity of ETo to minimum air temperature (Tmin) at middle elevations was lowest among three elevation bands; (4) RH and sunshine duration (SD) were the dominant climatic factors of ETo for most periods and stations. This study helps us understand the impact of climate change on ETo in mountainous areas and confirms reference evapotranspiration in high-elevation areas is particularly sensitive to climate change.
Development of a Framework for the Implementation of Synchronous Digital Mental Health: A Realist Synthesis of Systematic Reviews

David Villarreal-Zegarra IPOPS: Instituto Peruano de Orientacion Psicologica Christoper A. Alarcon-Ruiz San Ignacio de Loyola University: Universidad San Ignacio de Loyola GJ Melendez-Torres University of Exeter Medical School Roberto Torres-Puente IPOPS: Instituto Peruano de Orientacion Psicologica Alba Navarro-Flores IPOPS: Instituto Peruano de Orientacion Psicologica Victoria Cavero Red de Investigacion en Servicios de Salud en Enfermedades Cronicas Juan Ambrosio-Melgarejo IPOPS: Instituto Peruano de Orientacion Psicologica Jefferson Rojas-Vargas National University of San Marcos San Fernando School of Medicine: Universidad Nacional Mayor de San Marcos Facultad de Medicina de San Fernando Guillermo Almeida IPOPS: Instituto Peruano de Orientacion Psicologica Leonardo Albitres-Flores Red de Investigacion en Servicios de Salud en Enfermedades Cronicas Alejandra B. Romero-Cabrera Universidad Cientí ca del Sur: Universidad Cienti ca del Sur Jeff Huarcaya-Victoria (  jhuarcayav@usmp.pe ) Hospital Nivel IV Guillermo Almenara Irigoyen https://orcid.org/0000-0003-4525-9545
Cultural diversity''s impact on interaction process and performance: Comparing homogeneous and diver

The interaction process and performance of culturally homogeneous and culturally diverse groups were studied for 17 weeks. Initially, homogeneous groups scored higher on both process and performance effectiveness. Over time, both types of group showed improvement on process and performance, and the between-group differences converged. By week 17, there were no differences in process or overall performance, but the heterogeneous groups scored higher on two task measures, Implications for management and future research are given.
Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential biomarkers in patients with severe hidradenitis suppurativa who are candidates for biologic therapy and to explore potentially associated factors. A cross-sectional study was performed. Body mass index (BMI), carotid intima-media thickness (IMT), and blood tests, including glycemic and lipid profile, insulin, vitamin D, and inflammation markers were performed. Fifty patients were included in the study; the male/female ratio was 3:2. The mean age was 38 years, and the mean disease duration was 21.8 years. The mean carotid IMT was 651.39 μm. A positive association of IMT with disease duration, tobacco consumption, and HbA1c levels was observed. HbA1c correlated with the age of onset, hypertension, metabolic syndrome, and glucose levels. Vitamin D levels inversely correlated with the number of areas affected. In conclusion, patients with severe HS present a higher cardiovascular risk, but it is not distributed equally within the patients: Tobacco consumption, inadequate glycemic control, and disease duration could be useful clinical and biochemical markers to identify patients at higher risk.
Intimate Partner Violence Against Women: A Study on the Beliefs of Trainee Teachers in Spain and Latin America

Abstract. Objective: The main aim of this study is to analyse the acceptance of distorted beliefs about gender roles and violence against women in a sample of future teachers from Spain and Latin America. Method: The methodology used has been quantitative, and the design is cross-sectional. The sampling was intentional and not probabilistic. The sample is composed of 2395 trainee teachers who studied at universities and higher education centers from Argentina, Chile, Colombia, El Salvador, Spain, and Mexico. Information was collected through a structured questionnaire that included the Inventory of Distorted Thoughts about Women and the Use of Violence-Revised (Echeburúa et al., 2016). The analysis used (chi-square, Student T, and ANOVA) made it possible to evaluate the inﬂuence of sex and country. Results: The results show statistically signiﬁcant diﬀerences among countries in the acceptance of distorted beliefs. Men, compared to women, tend to present more cognitive distortions about gender roles and intimate partner violence against women. Conclusion: The education system is one of the main socialising agents, so teacher training in equality is essential to eliminate gender biases and contribute to the promotion of a society free of violence against women.
High Poly(ADP-Ribose) Polymerase Expression Does Relate to Poor Survival in Solid Cancers: A Systematic Review and Meta-Analysis

Simple Summary Poly (ADP-ribose) polymerases (PARPs) are DNA damage repair proteins that are involved in various biological activities ranges from cell proliferation to cell death. The prognostic significance of PARPs is not fully clarified in various cancers. This systematic review aims to reveal the prognostic value of PARP expression in solid cancers and to further correlate with clinicopathological and immunohistochemical markers. Lastly, the inhibition of this pathway through its specific inhibitors may increase the survival of patients with high PARP expression. Abstract Poly (ADP-ribose) polymerase (PARP) is a DNA damage repair protein, and its inhibitors have shown promising results in clinical trials. The prognostic significance of PARP is inconsistent in studies of various cancers. In the present study, we conducted a systematic review and meta-analysis to reveal the prognostic and clinicopathological significance of PARP expression in multiple solid cancers. We searched the MEDLINE, EMBASE, and Cochrane databases for relevant research articles published from 2005 to 2021. The pooled hazard ratio (HR) with confidence interval (CI) was calculated to investigate the relationship between PARP expression and survival in multiple solid cancers. In total, 10,667 patients from 31 studies were included. A significant association was found between higher PARP expression and overall survival (OS) (HR = 1.54, 95% CI = 1.34–1.76, p < 0.001), disease-free survival (DFS) (HR = 1.15, 95% CI = 1.10–1.21, p < 0.001), and progression-free survival (PFS) (HR = 1.05, 95% CI = 1.03–1.08, p < 0.001). Subgroup analyses showed that PARP overexpression was significantly related to poor OS in patients with breast cancers (HR = 1.38, 95% CI = 1.28–1.49, p < 0.001), ovary cancers (HR = 1.21, 95% CI = 1.10–1.33, p = 0.001), lung cancers (HR = 2.11, 95% CI = 1.29–3.45, p = 0.003), and liver cancers (HR = 3.29, 95% CI = 1.94–5.58, p < 0.001). Regarding ethnicity, Asian people have almost twice their worst survival rate compared to Caucasians. The pooled odds ratio analysis showed a significant relationship between higher PARP expression and larger tumour size, poor tumour differentiation, lymph node metastasis, distant metastasis, higher TNM stage and lymphovascular invasion, and positive immunoreactivity for Ki-67, BRCA1, and BRCA2. In addition, nuclear expression assessed by the QS system using Abcam and Santa Cruz Biotechnology seems to be the most commonly used and reproducible IHC method for assessing PARP expression. This meta-analysis revealed that higher PARP expression was associated with a worse OS, DFS, and PFS in patients with solid cancers. Moreover, inhibition of this pathway through its specific inhibitors may extend the survival of patients with higher PARP expression.
Determining the Optimal Biomass of Macrophytes during the Ecological Restoration Process of Eutrophic Shallow Lakes

Many studies have shown that macrophytes play a significant role in controlling eutrophication; however, only a few of these are based on macrophyte biomass. Based on the growth characteristic of macrophytes, we propose an approach for the assessment of the optimal biomass of macrophytes in the decay and growth periods in Lake Datong (a shallow lake), using a lake ecological model. The results showed that the pollution load of the lake should be reduced by 50% while conforming to the Environmental Quality Standards for Surface Water (EQSSW) Class Ⅲ. In contrast, with an increase in the pollution load of 5%, the results indicate that the lake may deteriorate to a turbid state over the next few years. The macrophyte biomass should be harvested during the decay period, when 80% biomass is beneficial to the water quality of the eutrophic shallow lake. Based on macrophyte simulation from 2020–2024, the wet biomass of macrophytes should be controlled at 5.5 kg/m2. The current macrophyte biomass in Lake Datong is four-fold higher than the simulated optimal biomass. This study provides a reference for the adequate ecological restoration of the lake and its subsequent maintenance, as well as scientific support for improving the comprehensive evaluation standard of healthy lakes and the theoretical basis of lake ecological restoration.
Seismic collapse capacity of basic inelastic structures vulnerable to the P‐delta effect

The collapse capacity of earthquake‐excited inelastic nondeteriorating SDOF systems, which are vulnerable to the destabilizing effect of gravity loads (P‐delta effect), is evaluated. In this paper, the collapse capacity of the system subjected to a ground motion is defined as spectral acceleration at its initial structural period, at which the structure becomes unstable. Characteristic structural parameters, which affect the collapse capacity, are identified. Ground motion records of the ATC 63 far‐field set characterize severe earthquake excitation. In extensive incremental dynamic analyses studies, the impact of these parameters and of aleatory uncertainties on the collapse capacity is assessed and quantified. Median and percentile collapse capacities are plotted against the initial structural period leading to collapse capacity spectra. Nonlinear regression analyses are applied to derive analytical expressions of the design collapse capacity spectra and collapse fragility curves. The ultimate objective is to provide collapse capacity spectra for easy application and yet sufficient accurate assessment of the dynamic stability of flexible multistory buildings. Copyright © 2011 John Wiley & Sons, Ltd.
Perceived Parental Care and Next-Generation Family Members’ Succession Intentions: The Sequential-Mediating Role of General Self-Efficacy and Perceived Person-Job Fit

ABSTRACT Whereas the existing literature on the relationship between parental behavior and family business succession mainly focuses on parental behavior in the business domain, we highlight the importance of parental behavior in the family domain. Integrating attachment theory, the family business succession literature, and person-job fit literature, our study proposes a theoretical framework hypothesizing that general self-efficacy and perceived person-job fit mediate the association between perceived parental care (an underrepresented family-domain-specific parental behavior) and next-generation family members’ succession intentions. This framework is tested by data from two surveys and further verified by qualitative interviews of next-generation family members. Multivariate analysis results suggest that next-generation family members’ general self-efficacy and perceived person-job fit played a sequential-mediating role in the relationship between perceived parental care and next-generation family members’ succession intentions. Our interviews not only confirm these results but also reveal new insights, particularly into the specific Chinese context in the study of family business succession. 摘要 家长的行为如何影响家族企业传承？ 当前的大部分文献主要关注的是家长在企业领域的行为，而忽视了他们在家庭领域的行为。 本文通过整合依恋理论、家族企业继承文献和个人-工作匹配文献，提出了一个新的理论框架，假设家长在家庭领域对子女的关爱会通过两个机制影响下一代家族成员的继承意向：一个是他们的自我效能感，另一个是他们感知到的个人-工作匹配程度。 我们做了两个问卷调查，还对21位下一代家族成员进行了定性访谈，结果都支持了这个新的理论框架。
Impact of temporomandibular disorder on oral health-related quality of life in adolescents

The aim of this cross-sectional study was to assess the impact of temporomandibular disorder (TMD) on oral health-related quality of life (OHRQoL) of adolescents. The OHRQoL of adolescents undergoing dental treatment at a University clinic in 2019 was measured using the Brazilian version of the Oral Heath Impact Profile – 14 (OHIP-14). The diagnosis of TMD was performed using Research Diagnostic Criteria for Temporomandibular disorders (RDC/TMD). The patients were examined for other oral conditions and the parents/guardians answered questions addressing socioeconomic/demographic characteristics and the general health of the adolescents. Statistical analysis involves simple and multiple logistic regression models. Ninety male and female adolescents between 13 and 18 years of age participated in the study. The prevalence of negative impact on OHRQoL was 34%. In the unadjusted analysis, negative impact on OHRQoL was associated with a poorer self- perception of general and oral health of the adolescent, nonspecific symptoms including pain, and generalized anxiety disorder, caries, reports of dental pain, muscle disorders and disc displacement, and chronic pain related to TMD. In the adjusted model, negative impact on OHRQoL was associated with all diagnoses related to TMD on the RDC/TMD, except signs of depression. Adolescents with at least one diagnosis related to TMD were 4.13-fold more likely (95% CI:1.08-15.80) to have negative impact on OHRQoL than adolescents without a diagnosis of TMD. The different diagnostic categories of TMD had a negative impact on the OHRQoL of the adolescents analyzed in the present study.
The design of new, Pb-free solder alloys with improved properties

The goal of the research presented in this paper is to identify Pb-free alloys with melting temperatures close to or lower than that of the near-eutectic 40Pb-60Sn solder (melting point of 183/spl deg/C), and that with the best mechanical properties. We have obtained substantially improved mechanical properties through manipulation of alloy microstructures. The following three alloys with superior mechanical properties are discussed: i) Sn-3.5%Ag-1%Zn-0.5%Cu with a melting point of /spl sim/216/spl deg/C, ii) Sn-8%Zn-5%In-(0.1-0.5%)Ag with a melting point of /spl sim/187/spl deg/C, and iii) 54.5%Bi-45%Sn-0.5%Ag with a melting point of /spl sim/140/spl deg/C.
Epidemiological profile of Echinococcosis in Morocco from 2014 to 2018: case of Tangier-Tetouan-Al Hoceima Region

In Morocco, the National Hydatidosis Control Program has approved considerable progress. However, updating epidemiological profile data of the disease is necessary. This study is carried out to explore the characteristics and epidemiological profile of Hydatidosis in Tangier-Tetouan-Al-Hoceima region. We conducted a retrospective descriptive study from 28 April 2019 to 18 February 2020. The data collected covering 2014-2018 period from the program reports. The statistical analysis was performed by EpiInfo 7. In total, 94 cases were notified. In 2015, we recorded the highest incidence (0.83 cases/100.000 inhabitants). The highest percentage of patients was in Tetouan (28,7%). 54.3% of cases were women and 57.4% were from rural areas. The age of 47,3% of the cases was [18-40[years. The association between the professional status and sex was statistically significant (p<0.05). 94.4% of cases, in the first stage of infection, were diagnosed by ultrasound. 84.7% presented hepatic localization. Almost all cases (98.9%) were treated surgically. In conclusion, the National Hydatidosis Control Program should direct the actions in rural areas where the living conditions of the population are precarious. The study of canine Hydatidosis will also be necessary in the context of environmental health to carry out an integrated control for the human Hydatidosis disease.
A whole‐plant economics spectrum including bark functional traits for 59 subtropical woody plant species

The whole‐plant economics spectrum (PES) refers to the trade‐offs among the many plant functional traits that are commonly used as indicators of major adaptive strategies, thereby providing insights into plant distributions, ecosystem processes and evolution. However, there are few studies of what may be called the whole‐PES that integrates bark, wood and leaf functional traits for different leaf types and growth habits (evergreen vs. deciduous species). To address this gap in our knowledge, 6 bark traits, 7 wood traits (including mechanical support and nutrient transport characteristics) and 12 leaf traits (including chemical, structural and physiological characteristics) of 59 representative subtropical woody species were examined using principal component analysis (PCA) to determine PES strategies. The economics spectra of bark (BES), wood (WES) and leaves (LES), and the entire PES indicated that major traits represent resource acquisition strategies and conservation strategies clustering on the opposite ends of the PCA axis. A significant correlation was observed among the 25 functional traits. The data indicated that N and P nutrient levels were at the hub of BES, WES, LES and PES interrelationships. Evergreen and deciduous species had different WES and LES, and thus PES resource acquisition strategies. With the exception of the BES, evergreen species clustered on the conservative side, whereas deciduous species clustered on the acquisitive side. Synthesis. The PES presented here informs our understanding of whole‐plant responses to environmental differences, particularly regarding the role of N and P traits at the whole‐plant level. It also reveals and further supports the notion that evergreen and deciduous species, respectively, manifest conservative and acquisitive strategies, further informing our understanding of species biodiversity maintenance.
Does Working Capital Management Influence Operating and Market Risk of Firms?

Extant empirical studies have predominantly focused on the nexus between working capital management (WCM) and corporate profitability. While there is a dearth of literature on the nexus between WCM and a firm’s risk, the present study examines Pakistani-listed firms coming from 12 diverse industrial segments to observe this association for a time span of ten years (2005–2014). To ensure robustness, we employed a System Generalized Method of Moments (SGMM) regression estimation to investigate the influence of WCM on the operational and market risk for firms. Empirical testing revealed that higher working capital levels were associated with lower volatility in firms’ stock price, which shows that shareholders prefer a conservative working capital policy. Moreover, firms with better cash positions were subject to lesser stock market volatility. In contrast, excess working capital and a larger net trade cycle were associated with increased volatility in the operating income. Besides, firms with lower working capital levels relative to their respective industry experienced fewer fluctuations in their operating profits. Our findings assert that short-term financial management has important ramifications for firms’ operating and market fundamentals. Practical implications are discussed for corporate managers and relevant stakeholders.
Antimicrobial Efficacy of Herbal Root Canal Irrigants and 3% Sodium Hypochlorite against Enterococcus faecalis: An In-vitro Study

Nigella sativa (kalonji) has been used since ancient times as a nutritional supplement and for treating various infections and chronic ailments. As pathogens become resistant to most drugs, kalonji can be used as an alternative compound in modern medicines. The use of herbal extracts as endodontic irrigants might be beneficial as a part of a growing trend to seek natural remedies for dental treatment. Aim: To compare the antibacterial potency of Aqueous Nigella sativa extract, Aqueous Neem leaf extract, and 3% Sodium Hypochlorite. Materials and Methods: Test solutions were tested against E. faecalis (ATCC 29212) to check for their Minimum Inhibitory Concentration (MIC) by double dilution method and Kill time to measure their antimicrobial potency to be used as an intracanal irrigant. Results: The study's limitations show that Aqueous Nigella sativa extract has a better antimicrobial effect than Aqueous Neem leaf extract and 3% Sodium Hypochlorite solution against E. faecalis.
Dual-reflector synthesis based on analytical gradient-iteration procedures

Syntheses of shaped dual-reflector systems under the assumptions of physical optics usually involve some iterative optimisation procedure whereby a penalty function is minimised. It is shown that, when an analytical gradient procedure is compared with other approaches, it is very efficient. To illustrate its efficiency the procedure generates a dual-offset shaped-reflector system for the EUTELSAT II European-coverage pattern in 30 min on modern personal microcomputer.