Miracle-dz/UniFAR-FTUs huggingface dataset:
Advancing Health Research Impact through a Systemic Multi-Sectoral Approach: A Protocol for Introducing Reduced-Sodium Salts and Salty Condiments in Vietnam

Better alignment between health research organisations with the needs (and interests) of key stakeholders in the health policy and research system is critical to improving research impact. The George Institute for Global Health’s ‘Healthier Societies’ program focuses on harnessing the power of governments, markets, and communities to improve population level health equity outcomes and maximise research impact. This protocol outlines a systemic multi-sectoral approach to advance health research impact globally applied to a project to reduce population salt intake in Vietnam by introducing reduced-sodium salts and salty condiments. We defined a systemic multi-sectoral approach to be a strategy that involves engaging with government, market and communities in a deliberate and joined-up way to solve a problem in which they all have a role to play. The project objectives are to: (i) produce reduced-sodium fish sauce products and test consumer acceptability; (ii) investigate the market feasibility of introducing reduced-sodium foods (salt, bot canh and fish sauce) into the Vietnamese market; (iii) estimate the cost-effectiveness of three different government strategies to support the implementation of reduced-sodium products; and (iv) develop an advocacy roadmap to maximise potential research impact. Methods will include standard quality and safety assessments, consumer sensory testing for the locally produced reduced-sodium fish sauces, market feasibility assessment (including collating market data and semi-structured interviews with stakeholders), cost-effectiveness modelling (Markov cohort model), multi-sector stakeholder engagement, and the development of a coordinated advocacy strategy using the Kotter Plus framework. Health research organisations are increasingly seeking ways to achieve greater impact with their research. Through the application of a systemic multi-sectoral approach with governments, markets and communities, this protocol provides an example of how health research projects can achieve such impact.
Eight new quasars discovered by the Guoshoujing Telescope (LAMOST) in one extragalactic field

We report the discovery of eight new quasars in one extragalactic field (a five-degree field centered at RA=08(superscript h)58(superscript m)08.2(superscript s), Dec=01°32'29.7”) with the Guoshoujing Telescope (LAMOST) commissioning observations made on 2009 December 18. These quasars, with i magnitudes from 16.44 to 19.34 and redshifts from 0.898 to 2.773, were not identified in the SDSS spectroscopic survey, though six of them with redshifts less than 2.5 were selected as quasar targets in SDSS. Except for one source without near-IR Y-band data, seven of these eight new quasars satisfy a newly proposed quasar selection criterion involving both near-IR and optical colors. Two of them were found in the 'redshift desert' for quasars (z from 2.2 to 3), indicating that the new criterion is efficient for uncovering missing quasars with similar optical colors to stars. Although LAMOST encountered some problems during the commissioning observations, we were still able to identify 38 other known SDSS quasars in this field, with i magnitudes from 16.24 to 19.10 and redshifts from 0.297 to 4.512. Our identifications imply that a substantial fraction of quasars may be missing in previous quasar surveys. The implication of our results to the future LAMOST quasar survey is discussed.
Feasibility of transit photometry of nearby debris discs

Dust in debris discs is constantly replenished by collisions between larger objects. In this paper, we investigate a method to detect these collisions. We generate models based on recent results on the Fomalhaut debris disc, where we simulate a background star transiting behind the disc, due to the proper motion of Fomalhaut. By simulating the expanding dust clouds caused by the collisions in the debris disc, we investigate whether it is possible to observe changes in the brightness of the background star. We conclude that in the case of the Fomalhaut debris disc, changes in the optical depth can be observed, with values of the optical depth ranging from 10 −0.5 for the densest dust clouds to 10 −8 for the most diffuse clouds with respect to the background optical depth of ∼1.2 × 10 −3 .
Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca2+ Entry and Interaction with PI3K/CaM

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers globally, with a 5-year overall survival of less than 10%. The development and progression of PDAC are linked to its fluctuating acidic tumor microenvironment. Ion channels act as important sensors of this acidic tumor microenvironment. They transduce extracellular signals and regulate signaling pathways involved in all hallmarks of cancer. In this study, we evaluated the interplay between a pH-sensitive ion channel, the calcium (Ca2+) channel transient receptor potential C1 (TRPC1), and three different stages of the tumor microenvironment, normal pH, acid adaptation, and acid recovery, and its impact on PDAC cell migration, proliferation, and cell cycle progression. In acid adaptation and recovery conditions, TRPC1 localizes to the plasma membrane, where it interacts with PI3K and calmodulin, and permits Ca2+ entry, which results in downstream signaling, leading to proliferation and migration. Thus, TRPC1 exerts a more aggressive role after adaptation to the acidic tumor microenvironment. Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a low overall survival rate of less than 10% and limited therapeutic options. Fluctuations in tumor microenvironment pH are a hallmark of PDAC development and progression. Many ion channels are bona fide cellular sensors of changes in pH. Yet, the interplay between the acidic tumor microenvironment and ion channel regulation in PDAC is poorly understood. In this study, we show that acid adaption increases PANC-1 cell migration but attenuates proliferation and spheroid growth, which are restored upon recovery. Moreover, acid adaptation and recovery conditions favor the plasma membrane localization of the pH-sensitive calcium (Ca2+) channel transient receptor potential C1 (TRPC1), TRPC1-mediated Ca2+ influx, channel interaction with the PI3K p85α subunit and calmodulin (CaM), and AKT and ERK1/2 activation. Knockdown (KD) of TRPC1 suppresses cell migration, proliferation, and spheroid growth, notably in acid-recovered cells. KD of TRPC1 causes the accumulation of cells in G0/G1 and G2/M phases, along with reduced expression of CDK6, −2, and −1, and cyclin A, and increased expression of p21CIP1. TRPC1 silencing decreases the basal Ca2+ influx in acid-adapted and -recovered cells, but not in normal pH conditions, and Ca2+ chelation reduces cell migration and proliferation solely in acid adaptation and recovery conditions. In conclusion, acid adaptation and recovery reinforce the involvement of TRPC1 in migration, proliferation, and cell cycle progression by permitting Ca2+ entry and forming a complex with the PI3K p85α subunit and CaM.
The cohomology of λ-rings and ψ-rings

The cohomology of λ-rings and Ψ-rings by Michael Robinson In this thesis we develop the cohomology of diagrams of algebras and then apply this to the cases of the λ-rings and the Ψ-rings. A diagram of algebras is a functor from a small category to some category of algebras. For an appropriate category of algebras we get a diagram of groups, a diagram of Lie algebras, a diagram of commutative rings, etc. We define the cohomology of diagrams of algebras using comonads. The cohomology of diagrams of algebras classifies extensions in the category of functors. Our main result is that there is a spectral sequence connecting the cohomology of the diagram of algebras to the cohomology of the members of the diagram. Ψ-rings can be thought of as functors from the category with one object associated to the multiplicative monoid of the natural numbers to the category of commutative rings. So we can apply the theory we developed for the diagrams of algebras to the case of Ψ-rings. Our main result tells us that there is a spectral sequence connecting the cohomology of the Ψ-ring to the Andre-Quillen cohomology of the underlying commutative ring. The main example of a λ-ring or a Ψ-ring is the K-theory of a topological space. We look at the example of the K-theory of spheres and use its cohomology to give a proof of the classical result of Adams. We show that there are natural transformations connecting the cohomology of the K-theory of spheres to the homotopy groups of spheres. There is a very close connection between the cohomology of the K-theory of the 4n-dimensional spheres and the homotopy groups of the (4n− 1)dimensional spheres.
Local temperature of an interacting quantum system far from equilibrium

A theory of local temperature measurement of an interacting quantum electron system far from equilibrium via a floating thermoelectric probe is developed. It is shown that the local temperature so defined is consistent with the zeroth, first, second, and third laws of thermodynamics, provided the probe-system coupling is weak and broad band. For non-broad-band probes, the local temperature obeys the Clausius form of the second law and the third law exactly, but there are corrections to the zeroth and first laws that are higher-order in the Sommerfeld expansion. The corrections to the zeroth and first laws are related, and can be interpreted in terms of the error of a nonideal temperature measurement. These results also hold for systems at negative absolute temperature.
IS THE UNIVERSE ROTATING?

Models of a rotating universe have been studied widely since the work of Gödel, who showed an example that is consistent with general relativity. By now, the possibility of a rotating universe has been discussed comprehensively in the framework of some types of Bianchi's models, such as Type V, VII, and IX and different approaches have been proposed to constrain the rotation. Recent discoveries of some non-Gaussian properties of the Cosmic Microwave Background Anisotropies (CMBA), such as the suppression of the quadrupole and the alignment of some multipoles draw attention to some Bianchi models with rotation. However, cosmological data, such as those of the CMBA, strongly prefer a homogeneous and isotropic model. Therefore, it is of interest to discuss the rotation of the universe as a perturbation of the Robertson–Walker metric, to constrain the rotating speed by cosmological data and to discuss whether it could be the origin of the non-Gaussian properties of the CMBA mentioned above. Here, we derive the general form of the metric (up to second-order perturbations) which is compatible with the rotation perturbation in a flat Λ-CDM universe. By comparing the second-order Sachs–Wolfe effect due to rotation with the CMBA data, we constrain the angular speed of the rotation to be less than 10−9 rad yr−1 at the last scattering surface. This provides the first constraint on the shear-free rotation of a ΛCDM universe.
Oxidative Stress and Autophagy Mediate Anti-Cancer Properties of Cannabis Derivatives in Human Oral Cancer Cells

Simple Summary The legalization of cannabis in 2018 in Canada has generated a heated public debate. The subject is complex, controversial, and completely opposite currents of thought clash mainly regarding its recreational use. The therapeutic efficacy of cannabis is very limited and still needs to be confirmed or refuted. However, our recent work has shown that at low doses, cannabinoids (Δ9-THC and Δ8-THC), which are the main constituents of cannabis, are beneficial against oral cancer. In this current study, we showed that a mixture of cannabinoids (CM) can induce oral toxicity in cells by damaging the DNA and activating the mechanisms of autophagy and apoptosis along with inhibiting many cancer progression pathways such as MAPKase, STATs and NF-κB pathways. These data demonstrated clearly the potential beneficial effect of CM at low concentrations for oral cancer therapy. Abstract Cannabinoids, the active components of cannabis exert palliative effects in cancer patients by preventing nausea, vomiting and pain as well as by stimulating appetite. Recent studies indicated that cannabinoids could be helpful in treating certain rare forms of cancer and other inflammatory diseases. The objective of this study was to investigate the cytotoxic effect of a cannabinoid mixture (CM) in oral cells. Thus, normal and cancer gingival cells were treated with different concentrations of CM to evaluate their proliferation by MTT assay, cytotoxicity by using LDH assay, colony formation with crystal violet and migration by the scratch method. In addition, apoptosis, autophagy, oxidative stress, antioxidant level, DNA damage and the mitochondrial membrane potential (ΔΨm) generated by proton pumps were measured by flow cytometry. Furthermore, deactivation of the key signaling pathways involved in cancer progression such as NF-κB, ERK1/2, p38, STAT1, STAT3, STAT5 was also evaluated by this technique. These outcomes indicate that CM, at a concentration higher than 0.1 µg/mL, provokes high cytotoxicity in Ca9-22 oral cancer cells but not in GMSM-K gingival normal cells. Apoptosis, autophagy, antioxidant levels and mitochondrial stress as well as DNA damage in oral cells were increased following exposure to low concentration (1 µg/mL). In addition, major signaling pathways that are involved such as MAPKase, STATs and NF-κB pathways were inhibited by CM as well as cell migration. Our results suggest that cannabinoids could potentially have a beneficial effect on oral cancer therapy.
Making Space to Sensemake: Epistemic Distancing in Small Group Physics Discussions

Abstract Students in inquiry science classrooms face an essential tension between sharing new ideas and critically evaluating those ideas. This tension poses affective risks that can discourage further discussion, such as the embarrassment of having an idea rejected. In this article, we analyze the discourse of three groups of undergraduate physics students in their first discussions of the semester, detailing how they navigate these tensions to create a safe space to collaboratively sensemake. We identify a discursive resource—epistemic distancing—that can protect students’ affect while they share and critique ideas. We find the groups differ in how soon, how often, and how deeply they sensemake together. These differences can be explained, in part, by how they epistemically distance themselves from their claims. Implications for research include the importance of considering the coupled dynamics of students’ epistemology and affect. Implications for instruction include novel ways of encouraging classroom discussion.
The metallicity of the long GRB hosts and the fundamental metallicity relation of low-mass galaxies

We investigate the metallicity properties of host galaxies of long gamma-ray bursts (GRBs) in the light of the fundamental metallicity relation (FMR), the tight dependence of metallicity on mass and star formation rate (SFR) recently discovered for Sloan Digital Sky Survey galaxies with stellar masses above 10 9.2 M� . As most of the GRB hosts have masses below this limit, the FMR can only be used after an extension towards lower masses. With this aim, we study the FMR for galaxies with masses down to ∼10 8.3 M� , finding that the FMR does extend smoothly at lower masses, albeit with a much larger scatter. We then compare the resulting FMR with the metallicity properties of 18 host galaxies of long GRBs. While the GRB hosts show a systematic offset with respect to the mass–metallicity relation, they are fully consistent with the FMR. This shows that the difference with the mass–metallicity relation is due to higher than average SFRs and that GRBs with optical afterglows do not preferentially select low-metallicity hosts among the star-forming galaxies. The apparent low metallicity is therefore a consequence of the occurrence of a long GRB in low-mass, actively star-forming galaxies, known to dominate the current cosmic SFR.
Emergence of spacetime dynamics in entropy corrected and braneworld models

A very interesting new proposal on the origin of the cosmic expansion was recently suggested by Padmanabhan [arXiv:1206.4916]. He argued that the difference between the surface degrees of freedom and the bulk degrees of freedom in a region of space drives the accelerated expansion of the universe, as well as the standard Friedmann equation through relation V = t(Nsur−Nbulk). In this paper, we first present the general expression for the number of degrees of freedom on the holographic surface, Nsur, using the general entropy corrected formula S = A/(4Lp2)+s(A). Then, as two example, by applying the Padmanabhan's idea we extract the corresponding Friedmann equations in the presence of power-law and logarithmic correction terms in the entropy. We also extend the study to RS II and DGP braneworld models and derive successfully the correct form of the Friedmann equations in these theories. Our study further supports the viability of Padmanabhan's proposal.
Investigating Factors Influencing Students’ Behavioral Intentions Towards Mobile Learning Devices in Higher Educational Institutions

This study adopted two key variables of the technology acceptance model, thus perceived usefulness, self-efficacy, and (gratification) variable of uses and gratification theory to understand how the three variables predict students’ behavioral intentions towards the use of mobile learning devices (MLDs). The sample was drawn from 447 selected participants from four private universities in Gaborone, Botswana. The researcher analyzed the data and presented the findings by testing the suggested research model and the hypotheses through structural equation modeling. Regression analysis was carried out with SmartPLS to assess the path coefficient of the data collected for the model. The findings suggest that two of the key variables tested, thus self-efficacy and perceived usefulness of MLDs positively influenced students’ gratification and were statistically significant. However, two out of the three of the determinant variables of perceived usefulness (information seeking, and social connections) all had positive relations with students’ perceptions of gratification, and behavioral intentions towards MLDs. This study concludes that, information seeking, and social connections variables of the perceived usefulness, connote the positive relationships with students’ perceptions of gratification with MLDs. Furthermore, the findings suggest that students could improve behavioral intentions concerning the relevance of MLDs application in institutions of higher learning by applying varied MLDs at their disposal.
Proanthocyanidins from Vaccinium vitis-idaea L. Leaves: Perspectives in Wound Healing and Designing for Topical Delivery

The compositions and health-beneficial properties of lingonberry leaves (Vaccinium vitis-idaea L.) are well established; however, their proanthocyanidins are still heavily underutilized. Optimizing their delivery systems is key to enabling their wider applications. The present study investigates the phytochemical and ‘wound-healing’ properties of proanthocyanidin-rich fraction(s) (PRF) from lingonberry leaves as well as the development of optimal dermal film as a proanthocyanidin delivery system. The obtained PRF was subjected to HPLC-PDA and DMAC analyses to confirm the qualitative and quantitative profiles of different polymerization-degree proanthocyanidins. A ‘wound healing’ in vitro assay was performed to assess the ability of PRF to modulate the wound environment for better healing. Low concentrations of lingonberry proanthocyanidins were found to accelerate ‘wound‘ closures, while high levels inhibited human fibroblast migration. Fifteen dermal films containing PRF were prepared and evaluated based on their polymer (MC, HEC, PEG 400) compositions, and physical, mechanical, and biopharmaceutical properties using an experimental design. The composition containing 0.30 g of MC, 0.05 g of HEC, and 3.0 g of PEG 400 was selected as a promising formulation for PRF delivery and a potentially effective functional wound dressing material, supporting the need for further investigations.
Course of Values of Key Performance Indicators in City Hotels during the COVID-19 Pandemic: Poland Case Study

The main goal of this article is to assess the functioning of hotels during the crisis caused by the COVID-19 pandemic. The analysis was carried out on the basis of selected Key Performance Indicators (KPI) in hotels in Polish cities (Kraków; Poznań; Tri-City: Gdańsk, Gdynia, Sopot; Warsaw; Wrocław). The time range of the analysis covers the whole period of the COVID-19 pandemic in Poland (March 2020–February 2022) with data for 2019—before the outbreak of the pandemic. The analysis of the collected results of OCC, ADR, and RevPAR generally indicates instability of the basic economic indicators dependent not only on the demand limited by the pandemic restrictions but also on the type of tourism prevailing in individual cities. There is a difference between the hotel industry in cities, based mainly on foreign guests and business tourism, and the hotel industry in tourist/coastal regions, which are dominated by leisure tourism. During the greatest restrictions, hotels in Poland recorded huge drops in KPIs: a 95% drop in OCC and RevPAR. It was also found that the instability of demand during the pandemic and rapid changes in the values of the indicators prove the need for greater use of KPI benchmarks.
The number of beds occupied is an independent risk factor for discharge of trauma patients

Reducing the burden of limited capacity on medical practitioners and public health systems requires a time-dependent characterization of hospitalization rates, such that inferences can be drawn about the underlying causes for hospitalization and patient discharge. The aim of this study was to analyze non-medical risk factors that lead to the discharge of trauma patients. This retrospective cohort study includes trauma patients who were treated in Switzerland between 2011 and 2018. The national Swiss database for quality assurance in surgery (AQC) was reviewed for trauma diagnoses according to the ICD-10 code. Non-medical risk factors include seasonal changes, daily changes, holidays, and number of beds occupied by trauma patients across Switzerland. Individual patient information was aggregated into counts per day of total patients, as well as counts per day of levels of each categorical variable of interest. The ARIMA-modeling was utilized to model the number of discharges per day as a function of auto aggressive function of all previously mentioned risk factors. This study includes 226,708 patients, 118,059 male (age 48.18, standard deviation (SD) 22.34 years) and 108,649 female (age 62.57, SD 22.89 years) trauma patients. The mean length of stay was 7.16 (SD 14.84) days and most patients were discharged home (n = 168,582, 74.8%). A weekly and yearly seasonality trend can be observed in admission trends. The mean number of occupied trauma beds ranges from 3700 to 4000 per day. The number of occupied beds increases on weekdays and decreases on holidays. The number of occupied beds is a positive, independent risk factor for discharge in trauma patients; as the number of occupied beds increases at any given time, so does the risk for discharge. The number of beds occupied represents an independent non-medical risk factor for discharge. Capacity determines triage of hospitalized patients and therefore might increase the risk of premature discharge.