Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Acid Concentration and Etching Time on ﻿Composite Cement Adhesion to L﻿ithium﻿-silic﻿ate Glass Ceramics.

PURPOSE To evaluate the influence of hydrofluoric acid (HF) concentration and etching time on the microshear bond strength (µSBS) of RelyX Unicem 2 (3M Oral Care) to VITA Suprinity (Vita Zahnfabrik; zirconia-reinforced lithium-silicate glass ceramic: ZLS) and IPS e.max CAD (Ivoclar Vivadent; lithium-disilicate glass ceramic: LD). MATERIALS AND METHODS Forty-eight bars each were fabricated of ZLS and LD with Cerec InLab MC-XL. For each material, 8 groups were formed with respect to etching time (20, 40, 60, 120 s) and HF concentration (4.9% and 9.5%). In each group, after etching and silanization, 15 cylindrical specimens of RelyX Unicem 2 were built up for µSBS testing with a special device. Data were analyzed using three-way ANOVA. Failure modes were assessed using an optical stereomicroscope, classified as adhesive, cohesive in resin or ceramic, or mixed. Failure modes were statistically analyzed using Fisher's Exact Test. One bar per group was prepared for SEM observation of the etched surface. RESULTS ZLS showed significantly higher bond strengths than LD (p < 0.001). Etchant concentration was an influential factor with superior strengths after 4.9% HF etching (p = 0.009). Etching time did not significantly affect adhesion (p = 0.066). The material-etching interaction was statistically significant (p = 0.004). Particularly for ZLS, 4.9% HF etching obtained significantly higher bond strengths than did 9.5%. By using 4.9% HF, adhesion was significantly higher on ZLS than on LD. CONCLUSION Material and HF concentration influenced the adhesion between RelyX Unicem 2 composite cement and lithium-silicate glass ceramics. Etching time was not an influential factor. The use of 4.9% HF for 20 s proved to be the most effective etching treatment of the intaglio surface.
A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes

Significance Dysregulation of the alternative complement pathway due to impaired binding of complement factor H (CFH) to self-ligands or altered self-ligands (e.g. malondialdehyde [MDA]-modified molecules) involved in homeostasis can promote the development of complement-related diseases, such as age-related macular degeneration (AMD). We identified, in an unbiased GWAS approach, that common genetic variants within the CFH gene family (rs1061170 and the deletion of the complement factor H-related protein 1 and 3 genes [CFHR3 and CFHR1]) act as major modulators of CFH recruitment and its ability to regulate complement on MDA-epitopes. These findings demonstrate the importance of the genetic status within the CFH/CFHR3/CFHR1 locus in tissue homeostasis and provide a mechanistic explanation as to why deletion of CFHR3/CFHR1 is protective in AMD development. Genetic variants within complement factor H (CFH), a major alternative complement pathway regulator, are associated with the development of age-related macular degeneration (AMD) and other complementopathies. This is explained with the reduced binding of CFH or its splice variant factor H-like protein 1 (FHL-1) to self-ligands or altered self-ligands (e.g., malondialdehyde [MDA]-modified molecules) involved in homeostasis, thereby causing impaired complement regulation. Considering the critical role of CFH in inhibiting alternative pathway activation on MDA-modified surfaces, we performed an unbiased genome-wide search for genetic variants that modify the ability of plasma CFH to bind MDA in 1,830 individuals and characterized the mechanistic basis and the functional consequences of this. In a cohort of healthy individuals, we identified rs1061170 in CFH and the deletion of CFHR3 and CFHR1 as dominant genetic variants that modify CFH/FHL-1 binding to MDA. We further demonstrated that FHR1 and FHR3 compete with CFH for binding to MDA-epitopes and that FHR1 displays the highest affinity toward MDA-epitopes compared to CFH and FHR3. Moreover, FHR1 bound to MDA-rich areas on necrotic cells and prevented CFH from mediating its cofactor activity on MDA-modified surfaces, resulting in enhanced complement activation. These findings provide a mechanistic explanation as to why the deletion of CFHR3 and CFHR1 is protective in AMD and highlight the importance of genetic variants within the CFH/CFHR3/CFHR1 locus in the recognition of altered-self in tissue homeostasis.
The PNPLA3 rs738409 GG genotype is associated with poorer prognosis in 239 patients with autoimmune hepatitis

Fibrosis progression in autoimmune hepatitis can be attenuated by immunosuppressive treatment; however, some patients progress despite therapy. Single nucleotide polymorphisms (SNPs) such as PNPLA3‐rs738409, TM6SF2‐rs58542926 and MBOAT7‐rs641738 are associated with non‐alcoholic fatty liver disease and fibrosis progression, whereas a splice variant in HSD17B13‐rs72613567:TA has been shown to be protective.
A study on bacterial and fungal infections in patients with dacryocystitis in a Tertiary care hospital.

Inflammation of the lacrimal sac is known as dacryocystitis which usually occurs due to obstruction in the nasolacrimal duct. It is a significant cause of ocular morbidity in children and adults. It can be congenital or acquired. Acquired dacryocystitis can occur as acute and chronic dacryocystitis. Dacryocystitis is mostly caused by bacteria and rarely by fungi. There is a change in etiological agents causing dacryocystitis over the time. Hence this study was undertaken to know the etiological agents of congenital, acute and chronic dacryocystitis Microbial culture and sensitivity should be performed in all dacryocystitis cases. This would contribute to the choice of appropriate and effective antimicrobial agents
Non-communicable Diseases in Ethiopia: Disease burden, gaps in health care delivery and strategic directions.

Abstract Introduction : In Ethiopia, non-communicable diseases (NCDs) cause 42% of deaths, of which 27% are premature deaths before 70 years of age. The Disability Adjusted Life Years (DALYs) increased from below 20% in 1990 to 69% in 2015. With no action, Ethiopia will be the first among the most populous nations in Africa to experience dramatic burden of premature deaths and disability from NCDs by 2040. However, the national response to NCDs remains fragmented with the total health spending per capita for NCDs still insignificant. The focus of this paper is highlighting the burden of NCDs in Ethiopia and analyzing one of the two major WHO recommended policy issues; the status of integrated management of NCDs, in Ethiopia. NCDs are complex conditions influenced by a range of individual, social and economic factors, including our perceptions and behavior. Also, NCDs tend to be easily overlooked by individuals and policy makers due to their silent nature. Thus, effectively addressing NCDs requires a fresher look into a range of health system issues, including how health services are organized and delivered. Methods : A mixed method approach with quantitative and qualitative data was used. Quantitative data was obtained through analysis of the global burden of diseases study, WHO-STEPs survey, Ethiopian SARA study and the national essential NCD drug survey. This was supplemented by qualitative data through review of a range of documents, including the national NCD policies and strategies and global and regional commitments. Results and discussion: In 2015, NCDs were the leading causes of age-standardized death rate (causing 711 deaths per 100,000 people (95% UI: 468.8–1036.2) and DALYs. The national estimates of the prevalence of NCD metabolic risk factors showed high rates of raised blood pressure (16%), hyperglycemia (5.9%), hypercholesterolemia (5.6%), overweight (5.2%) and Obesity (1.2%). Prevalence of 3-5 risk factors constituting a metabolic syndrome was 4.4%. Data availability on NCD morbidity and mortality is limited. While there are encouraging actions on NCDs in terms of political commitment, lot of gaps as shown by limited availability of resources for NCDs, NCD prevention and treatment services at the primary health care (PHC) level. Shortage of essential NCD drugs and diagnostic facilities and lack of treatment guidelines are major challenges. There is a need to re-orient the national health system to ensure recognition of the NCD burden and sustain political commitment, allocate sufficient funding and improve organization and delivery of NCD services at PHC level. [Ethiop. J. Health Dev. 2018;32 (3):00-000] Key words : Non-communicable diseases, health-system re-orientation, NCD burden, metabolic risk factors, Service delivery, Primary Health Care
Modelling performance during repetitive precision tasks using wearable sensors: a data-driven approach

Abstract In modern manufacturing systems, especially assembly lines, human input is a critical resource to provide dexterity and flexibility. However, the repetitive precision tasks common in assembly lines can have adverse effects on workers and overall system performance. We present a data-driven approach to evaluating task performance using wearable sensor data (kinematics, electromyography and heart rate). Eighteen participants (gender-balanced) completed repeated cycles of maze tracking and assembly/disassembly. Various combinations of input data types and classification algorithms were used to model task performance. The use of the linear discriminant analysis (LDA) algorithm and kinematic data provided the most promising classification performance. The highest model accuracy was found using the LDA algorithm and all data types, with respective levels of 62.4, 88.6, 85.8 and 94.1% for predicting maze errors, maze speed, assembly/disassembly errors and assembly/disassembly speed. The presented approach provides the possibility for real-time, on-line and comprehensive monitoring of system performance in assembly-lines or similar industries. Practitioner summary: This paper proposed models the repetitive precision task performance using data collected from wearable sensors. The use of the LDA algorithm and kinematic data provided the most promising classification performance. The presented approach provides the possibility for real-time, on-line and comprehensive monitoring of system performance in assembly lines or similar industries. Abbreviations: AD: anterior deltoid; BB: biceps brachii; ECR: extensor carpi radialis; ECU: extensor carpi ulnaris; FCR: flexor carpi radialis; FCU: flexor carpi ulnaris; FN: false negatives; FP: false positives; HR: heart rate; HRR: heart rate reserve; IMUs: inertial measurement units; kNN: k-nearest neighbors; LDA: linear discriminant analysis; MD: medial deltoid; MF: median power frequency; MNF: mean power frequency; MVIC: maximum voluntary isometric contraction; nRMS: normalized root-mean-square amplitudes; PD: posterior deltoid; RandFor: random forests; RHR: resting heart rate; RMS: root-mean-square amplitudes; sEMG: surface electromyographic; SVM: support vector machines; TB: triceps brachii medial; TN: true negatives; TP: true positives; t-SNE: t-distributed Stochastic Neighbor Embedding; UT: upper trapezius
Temporal Associations of Daily Changes in Sleep and Depression Core Symptoms in Patients Suffering From Major Depressive Disorder: Idiographic Time-Series Analysis

Background There is a strong link between sleep and major depression; however, the causal relationship remains unclear. In particular, it is unknown whether changes in depression core symptoms precede or follow changes in sleep, and whether a longer or shorter sleep duration is related to improvements of depression core symptoms. Objective The aim of this study was to investigate temporal associations between sleep and depression in patients suffering from major depressive disorder using an idiographic research approach. Methods Time-series data of daily sleep assessments (time in bed and total sleep time) and self-rated depression core symptoms for an average of 173 days per patient were analyzed in 22 patients diagnosed with recurrent major depressive disorder using a vector autoregression model. Granger causality tests were conducted to test for possible causality. Impulse response analysis and forecast error variance decomposition were performed to quantify the temporal mutual impact of sleep and depression. Results Overall, 11 positive and 5 negative associations were identified between time in bed/total sleep time and depression core symptoms. Granger analysis showed that time in bed/total sleep time caused depression core symptoms in 9 associations, whereas this temporal order was reversed for the other 7 associations. Most of the variance (10%) concerning depression core symptoms could be explained by time in bed. Changes in sleep or depressive symptoms of 1 SD had the greatest impact on the other variable in the following 2 to 4 days. Conclusions Longer rather than shorter bedtimes were associated with more depression core symptoms. However, the temporal orders of the associations were heterogeneous.
Double‐hit and double‐expressor B‐cell lymphomas: Current treatment strategies and impact of hematopoietic cell transplantation

High‐grade B‐cell lymphoma with rearrangement of MYC and BCL2 and/or BCL6 (double‐hit lymphoma: DHL) was newly categorized as a subtype in the 2016 revision of the WHO classification of lymphoid neoplasms. DHL is a rare entity accounting for <10% of DLBCL and clinical data of DHL cases are still limited. Standard rituximab‐incorporated chemotherapy was reported to be underpowered for this intractable disease, and some promising results with intensified regimen including dose‐adjusted EPOCH‐R (rituximab, etoposide, vincristine, adriamycin, cyclophosphamide, and prednisone) have been emerging. The benefit of intensified regimen for DHL patients should be determined in randomized trials. The role of consolidative autologous (auto) hematopoietic cell transplantation (HCT) for newly diagnosed cases has been also undetermined. In regards to salvage chemotherapy followed by auto‐HCT for chemotherapy‐sensitive relapsed cases, the prognosis seems to be unsatisfactory in patients with DHL, and novel treatment strategies to incorporate effective salvage, auto‐HCT and maintenance treatment after auto‐HCT are warranted. Clinical application of allogeneic (allo)‐HCT has not been established in newly diagnosed and refractory/relapsed (ref/rel) cases. Recently, favorable survival data of allo‐HCT for ref/rel DHL was reported. To clarify the indication of various treatment strategies, larger‐scaled studies or new prognostic models for DHL are required. As another topic, clinical investigation of several novel agents such as BCL2 inhibitor is conducted along with DLBCL. Here, we summarize the data relating to DHL focusing on the application of HCT, and also discuss about the combination therapy using novel agents in the setting of HCT.
Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae

Abstract Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.
The Prevalence of Arterial Hypertension in Romanian Adult Population: Results from the Predatorr Study

Abstract Background and aims: PREDATORR is a national study designed to estimate the prevalence of diabetes mellitus, prediabetes, overweight, obesity, dyslipidemia, hyperuricemia and chronic kidney disease in Romanian adult population. The aim of present study was to estimate the prevalence, incidence, treatment and control in subjects from PREDATORR study. Material and methods: This study included 2727 adults aged 20 – 79 years. Subjects were examined, and three measurements were performed at a time of at least one minute and the mean of blood pressure readings was recorded. Hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg and/or antihypertensive drug therapy. Results: The prevalence of hypertension in Romanian adult population aged 20 – 79 years was 47.38% and was higher in men: 48.62% than women: 46.23%. The incidence of hypertension was: 10.7% in 20 – 39 years age group, 43.1% in 40 – 59 years age group and 75.1% in subjects aged ≥ 60 years. Among subjects with hypertension, 18.7% did not receive antihypertensive drug therapy, 27.7% received antihypertensive treatment in monotherapy, 34.7% were under double antihypertensive drugs and most of them (37.6%) received three or more antihypertensive drugs. Conclusions: The prevalence of hypertension in Romania is high, possible explanations of this might be the unhealthy lifestyle and diet.
Exploring Balloon Sinuplasty Adverse Events With the Innovative OpenFDA Database

Background Balloon sinuplasty (BSP) has become a common, minimally invasive treatment for chronic sinusitis. Like any surgical procedure, there are definite risks when using it as a stand-alone procedure or in conjunction with other revision procedures. Objective To explore the adverse events of BSP using the openFDA cloud with regard to malfunction and injury following surgery. Methods Between January 2015 and December 2018, the Food and Drug Administration’s (FDA) openFDA database was queried for adverse event use. Reports were further categorized by procedure location, injury type, device malfunction, procedure (stand-alone BSP vs hybrid), and source of complication (anatomical or surgeon related). Results Seventy-eight events were reported to the FDA in the study period. Majority of cases consisted of device malfunctions (64.1%), while patient injuries consisted of 43.5%. Frontal sinus procedures had the greatest presence of adverse events (47.4%) with the majority reporting significant cerebrospinal fluid (CSF) leaks (P < .001) and device retention (P = .021). Orbital complications (P = .004) were found to be significantly associated with dilation of the maxillary sinus. Skull-based injuries were the only factor incident in which surgeon-reported anatomical complications were significant (P = .018). Conclusions As balloon dilation procedure continues to rise in the United States, significant adverse events continue to occur. Frontal sinus BSP leads to the highest number of complications and a 4.75 reported CSF leaks yearly. Based on real data, surgeons performing the procedure should be acquainted with common BSP-related injuries so they can prepare for those circumstances and share informed consent with their patients.
Complementarity between Arrhythmia Mechanisms Found in Silico and in Genetic Models of N588K-hERG Linked Short QT Syndrome

Congenital Short QT Syndrome (SQTS) is a rare but dangerous condition involving abbreviated ventricular repolarization and an increased risk of atrial and ventricular arrhythmias. Taking the example of the first identified SQTS mutation, N588K-hERG, we consider briefly the basic science approaches used to obtain an understanding of the mechanism(s) of arrhythmogenesis in this form of the syndrome. A combination of recombinant channel electrophysiology and in silico simulations has provided insights into causality between the identified mutation, accelerated repolarization and increased susceptibility to re-entry in N588K-hERG-linked SQTS. Subsequent studies employing a transgenic rabbit model or human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) have further demonstrated mechanisms predisposing to re-entry, spiral wave activity and arrhythmia in intact tissue. The complementarity between the findings made using these different approaches gives confidence that, collectively, they have identified major arrhythmia mechanisms and their potential mitigation by Class I antiarrhythmic drugs in this form of SQTS.
A Temporal-Causal Network Model to Model Different Emotion Regulation Strategies for Different Personal Characteristics 1

: In this paper a cognitive model is introduced which integrates a model for emotion generation with models for three different emotion regulation strategies. Given a stressful situation, humans often apply multiple emotion regulation strategies. The presented computational model has been designed based on principles from recent neurological theories based on brain imaging, and psychological and emotion regulation theories. More specifically, the model involves emotion generation and integrates models for the emotion regulation strategies reappraisal, expressive suppression, and situation modification. The model was designed as a dynamical system. Simulation experiments were conducted for two different types of personality characteristics. The simulation results show how a potential stressful situation in principle could lead to emotional strain and how this can be avoided by applying the emotion regulation strategies decreasing the stressful effects. Furthermore, mathematical analysis was also performed to check whether the model provides the required behavior correctly.
Paraphrase Identiﬁcation and Applications in Finding Answers in FAQ Databases

This work revisits the task of identifying paraphrases (i.e., given a pair of sentences, classify them as being paraphrases or not paraphrases). We propose to address the task through supervised machine learning, training classiﬁcation models based on ensembles of trees, which use features that mostly correspond to string similarity metrics relying on lexical information. The most innovative contributions of this work relate to (i) the usage of classiﬁcation methods based on tree ensembles, (ii) the combination of machine translation metrics with other types of features, and (iii) the usage of similarity features based on distributional word clustering. We report on a set of experiments that used the well-known Microsoft Research Paraphrase Corpus, in which we achieved a classiﬁcation accuracy of 0.77, and an F1 measure of 0.84. We therefore show that out-of-the-box learning algorithms and relatively simple features can obtain state-of-the-art results in this task.
Patent Foramen Ovale Is an Important Predictor of Adverse Outcome in Patients With Major Pulmonary Embolism

Background—Right-to-left shunt through a patent foramen ovale is frequently diagnosed by contrast echocardiography and can be particularly prominent in the presence of elevated pressures in the right side of the heart. Its prognostic significance in patients with pulmonary thromboembolism, however, is unknown. Methods and Results—The present prospective study included 139 consecutive patients with major pulmonary embolism diagnosed on the basis of clinical, echocardiographic, and cardiac catheterization criteria. All patients underwent contrast echocardiography at presentation. The end points of the study were overall mortality and complicated clinical course during the hospital stay defined as death, cerebral or peripheral arterial thromboembolism, major bleeding, or need for endotracheal intubation or cardiopulmonary resuscitation. Patent foramen ovale was diagnosed in 48 patients (35%). These patients had a death rate of 33% as opposed to 14% in patients with a negative echo-contrast examination (P=. 01.