Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of symptoms and risk of obstructive sleep apnea in Saudi pregnant women

BACKGROUND: This case-control study aimed to assess the prevalence of symptoms and risk of obstructive sleep apnea (OSA) among Saudi pregnant women. METHODS: The study included consecutive Saudi pregnant women attending the antenatal service between July 2015 and December 2016. Pregnant women were compared with an age-matched group of nonpregnant women. OSA symptoms and risk were assessed using a validated Arabic version of the Berlin questionnaire (BQ). RESULTS: The study included 742 pregnant women and 742 age-matched nonpregnant women. At the time of the survey, 8.2% were in the first trimester; 33.4% in the second trimester; and 58.4%in third trimester. Snoring was reported by 14% of pregnant women, and 5% reported breathing pauses during sleep. Based on the BQ stratification for risk of OSA, 19.3% of pregnant women and 16.6% of the control group were at high risk for OSA. A comparison between the high OSA-risk and low OSA-risk pregnant women revealed that the pregnant women in high risk group were older (30.9 ± 5.9 years vs. 29 ± 5.4 years, P = 0.001), had a higher body mass index (BMI) (34.3 ± 5.2 kg/m2 vs. 28.7 ± 5.8 kg/m2,P < 0.001), and higher parity (1.9 ± 2 vs. 1.5 ± 1.7, P = 0.020). A multivariate logistic regression analysis revealed the following independent variables, BMI (odds ratio [OR] 1.173 [95% confidence interval [CI] 1.129–1.219],P < 0.001), pregnancy-induced hypertension (OR 7.85 [95% CI 1.691–36.447], P = 0.013), and the presence of restless legs syndrome (OR 2.209 [95% CI 1.332–3.279],P < 0.001). CONCLUSIONS: OSA symptoms and risk were relatively common among Saudi pregnant women. Increasing the awareness among physicians about this association is essential to improve early detection of the disorder.
Enhanced tolerances of transgenic tobacco plants expressing both superoxide dismutase and ascorbate peroxidase in chloroplasts against methyl viologen- mediated oxidative stress

In order to better understand the role of antioxidant enzymes in plant stress protection mechanisms, transgenic tobacco (Nicotiana tabacum cv. Xanthi) plants were developed that overexpress both superoxide dismutase (SOD) and ascorbate peroxidase (APX) in chloroplasts. These plants were evaluated for protection against methyl viologen (MV, paraquat)-mediated oxidative damage both in leaf discs and whole plants. Transgenic plants that express either chloroplast-targeted CuZnSOD (C) or MnSOD (M) and APX (A) were developed (referred to as CA plants and AM plants, respectively). These plant lines were crossed to produce plants that express all three transgenes (CMA plants and AMC plants). These plants had higher total APX and SOD activities than non-transgenic (NT) plants and exhibit novel APX and SOD isoenzymes not detected in NT plants. As expected, transgenic plants that expressed single SODs showed levels of protection from MV that were only slightly improved compared to NT plants. The expression of either SOD isoform along with APX led to increased protection while expression of both SODs and APX provided the highest levels of protection against membrane damage in leaf discs and visual symptoms in whole plants.
A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial

Abstract Aim We tested the hypothesis that dapagliflozin may regress left ventricular hypertrophy (LVH) in people with type 2 diabetes (T2D). Methods and results We randomly assigned 66 people (mean age 67 ± 7 years, 38 males) with T2D, LVH, and controlled blood pressure (BP) to receive dapagliflozin 10 mg once daily or placebo for 12 months. Primary endpoint was change in absolute left ventricular mass (LVM), assessed by cardiac magnetic resonance imaging. In the intention-to-treat analysis, dapagliflozin significantly reduced LVM compared with placebo with an absolute mean change of −2.82g [95% confidence interval (CI): −5.13 to −0.51, P = 0.018]. Additional sensitivity analysis adjusting for baseline LVM, baseline BP, weight, and systolic BP change showed the LVM change to remain statistically significant (mean change −2.92g; 95% CI: −5.45 to −0.38, P = 0.025). Dapagliflozin significantly reduced pre-specified secondary endpoints including ambulatory 24-h systolic BP (P = 0.012), nocturnal systolic BP (P = 0.017), body weight (P < 0.001), visceral adipose tissue (VAT) (P < 0.001), subcutaneous adipose tissue (SCAT) (P = 0.001), insulin resistance, Homeostatic Model Assessment of Insulin Resistance (P = 0.017), and high-sensitivity C-reactive protein (hsCRP) (P = 0.049). Conclusion Dapagliflozin treatment significantly reduced LVM in people with T2D and LVH. This reduction in LVM was accompanied by reductions in systolic BP, body weight, visceral and SCAT, insulin resistance, and hsCRP. The regression of LVM suggests dapagliflozin can initiate reverse remodelling and changes in left ventricular structure that may partly contribute to the cardio-protective effects of dapagliflozin. ClinicalTrials.gov Identifier NCT02956811
The Link Between Adversity and Dating Violence Among Adolescents Hospitalized for Psychiatric Treatment: Parental Emotion Validation as a Candidate Protective Factor

Adolescents are at risk for becoming victims or perpetrators for a variety of forms of dating violence, including cyber violence, physical violence, psychological abuse, and sexual abuse. Interestingly, a robust predictor of dating violence is adverse experiences during childhood; however, factors that could mitigate the risk of dating violence for those exposed to adversity have seldom been examined. Using the cumulative stress hypothesis as a lens, the current study examined severity of adverse experiences as a predictor of dating violence within a sample at risk for both victimization and perpetration of dating violence: An adolescent (12–17 years old; N = 137) sample who were receiving inpatient psychiatric treatment. First, the current study aimed to replicate previous findings to determine whether adversity predicted dating violence and whether this varied by gender. Then, the current study examined one factor that could mitigate the relation between adversity and dating violence—parental emotion validation. High rates of maternal emotion validation resulted in no relation between adversity and dating violence perpetration and victimization; however, the relation was present at average and low levels of maternal emotion validation. Next, by adding gender as an additional moderator to the model, we found that high rates of paternal emotion validation extinguished the relation between adversity and dating violence perpetration, but only for adolescent boys. This pattern was not found for maternal emotion validation. Interestingly, the relation between adversity and dating violence victimization did not vary as a function of maternal or paternal validation of emotion for either child gender. These findings are discussed in terms of their meaning within this sample, possible future directions, and their implications for the prevention of dating violence.
Growth responses of Picea abies and Larix decidua to elevation in subalpine areas of Tyrol, Austria

Microsites related to microenvironmental conditions, including microclimate, seem to be a key factor for the restoration of forests in the subalpine area. Tree growth was studied in Picea abies (L.) Karst. (Norway spruce) and Larix decidua Mill. (European larch) on 30 plots located at different microsites (i.e., different elevations and micro top o graphies combined) within the subalpine zone (16801940 m) of the Schmirn Valley (Tyrol, Austria). The age of the trees studied was 27 years for larch and 28 years for spruce. The mean height and biomass growth decreased significantly with increasing elevation. The effect of elevation and microtopography on growth varied with tree size (age): (1) elevation had little effect on growth of trees less than 0.5 m in height; (2) both elevation and microtopography affected tree growth significantly when the tree height was between 0.5 and 3 m; (3) as trees exceed 3 m in height, tree canopies can fully cover the ground surface and create a forest microclimate causing g.
Predicting Degrees of Technicality in Automatic Terminology Extraction

While automatic term extraction is a well-researched area, computational approaches to distinguish between degrees of technicality are still understudied. We semi-automatically create a German gold standard of technicality across four domains, and illustrate the impact of a web-crawled general-language corpus on technicality prediction. When defining a classification approach that combines general-language and domain-specific word embeddings, we go beyond previous work and align vector spaces to gain comparative embeddings. We suggest two novel models to exploit general- vs. domain-specific comparisons: a simple neural network model with pre-computed comparative-embedding information as input, and a multi-channel model computing the comparison internally. Both models outperform previous approaches, with the multi-channel model performing best.
“No matter how old I am, I don’t like what my stomach looks like.” Lifespan perspective on the changes in self-assessment of attractiveness and life satisfaction in women

ABSTRACT The study aimed to examine the association between self-assessment of attractiveness and life satisfaction in women, where age was a potential moderator of this relationship. A cross-sectional study of 360 women aged 18 to 89 was performed. Participants assessed their overall attractiveness, the attractiveness of their individual body parts, and their life satisfaction. The relationship between the assessment of attractiveness of particular body parts and life satisfaction depended on age. The results indicate that not only overall self-attractiveness, but also the perceived attractiveness of particular body parts (different in each distinguished age group: 18–25, 30–45 and 60+) can be considered predictors of life satisfaction in women.
Locomotory mechanisms in Antarctic pycnogonids

Patterns of walking, modes of joint movement, and individual limb diversity were analysed with the aid of cine film of several living Antarctic pycnogonids, including the 8-legged Colossendeis australis, C. angusta, Pallenopsis patagonica, and Nymphon sp. , the 10-legged Decolopoda australis, and the 12-legged Dodecolopoda mawsoni. Appendage musculature of several of these species and also of the 10-legged Pentapycnon charcoti and Pentanymphon antarcticurn was dissected. At least two distinct morphotypes were identified: a short-legged, crawling variety (P. charcoti); and the more typical long-legged, large bodied, walking forms. No gross differences in musculature of joints were noted in the species examined. All joints are, at least superficially, hinge joints. The coxa-body joint is largely immobile, the coxa 1-coxa 2 joint alone exhibits promotion-remotion and all other joints are flexion-extension joints. The 8-legged forms move in an imprecise manner, there being irregularity of leg raising and lowering and where legs touch down in relation to the body and to other legs. The 10- and 12-legged forms exhibit more precise patterns of metachronal leg movements. Although legs move in a basic promotion-remotion, extension-flexion mode, there is a certain degree of twisting of a leg as it is picked up, brought forward, and set down; models indicating how such joint movement occurs were constructed. The possibility that hydrostatic pressure is employed in extension is considered and is found to be remote. Lateral placement of legs, orientated in almost all directions in the horizontal plane of the trunk, achieves a versatility of movement similar to that in crabs. Comments on pycnogonid taxonomic affinities are offered.
A Place to Live and to Die: A Qualitative Exploration of the Social Practices and Rituals of Death in Residential Aged Care

In many countries, an increasing proportion of deaths occur in residential aged care (RAC) (nursing homes) meaning that these have become both a place to live - a home- and a place to die. This paper reports on death practices and rituals in 49 RAC facilities in Aotearoa/New Zealand narrated in semi-structured interviews with staff. Themes coalesced around ‘good death’. Dying alone was not seen as a good death and the demands of trying to prevent this caused tension for staff. Meeting family wishes, post death decision-making, after death practices and rituals, including communicating and remembrance of the death, were explored as part of good death. Overall, death rituals in RAC were limited. Balancing the needs of the living, the dying and the dead created tension. The rituals and practices facilities are currently enacting in death/post-death require attention, since more people will die in RAC with increasingly diverse needs.
Forced Zika Virus Infection of Culex pipiens Leads to Limited Virus Accumulation in Mosquito Saliva

Zika virus (ZIKV) is a mosquito-borne pathogen that caused a large outbreak in the Americas in 2015 and 2016. The virus is currently present in tropical areas around the globe and can cause severe disease in humans, including Guillain-Barré syndrome and congenital microcephaly. The tropical yellow fever mosquito, Aedes aegypti, is the main vector in the urban transmission cycles of ZIKV. The discovery of ZIKV in wild-caught Culex mosquitoes and the ability of Culex quinquefasciatus mosquitoes to transmit ZIKV in the laboratory raised the question of whether the common house mosquito Culex pipiens, which is abundantly present in temperate regions in North America, Asia and Europe, could also be involved in ZIKV transmission. In this study, we investigated the vector competence of Cx. pipiens (biotypes molestus and pipiens) from the Netherlands for ZIKV, using Usutu virus as a control. After an infectious blood meal containing ZIKV, none of the tested mosquitoes accumulated ZIKV in the saliva, although 2% of the Cx. pipiens pipiens mosquitoes showed ZIKV–positive bodies. To test the barrier function of the mosquito midgut on virus transmission, ZIKV was forced into Cx. pipiens mosquitoes by intrathoracic injection, resulting in 74% (molestus) and 78% (pipiens) ZIKV–positive bodies. Strikingly, 14% (molestus) and 7% (pipiens) of the tested mosquitoes accumulated ZIKV in the saliva after injection. This is the first demonstration of ZIKV accumulation in the saliva of Cx. pipiens upon forced infection. Nevertheless, a strong midgut barrier restricted virus dissemination in the mosquito after oral exposure and we, therefore, consider Cx. pipiens as a highly inefficient vector for ZIKV.
Relationship between trunk control, core muscle strength and balance confidence in community-dwelling patients with chronic stroke

ABSTRACT Background and objective Impaired trunk control and core muscle weakness affect balance capacity after stroke, but confirmatory literature is lacking. The objective was to examine the relationship between trunk control, core muscle strength and self-confidence on balance efficacy in community-dwelling chronic stroke survivors and to identify trunk performance measures for determining balance confidence. Methods Patients with a median post-stroke duration of 12 (IQR 7–18) months and independent walking ability participated in this cross-sectional study. Trunk control, core muscle strength and balance confidence were measured using trunk impairment scale 2.0 (TIS 2.0), handheld dynamometer and activity-specific balance confidence scale, respectively. Correlation among TIS 2.0, core muscle strength and balance confidence were tested by Pearson’s correlation coefficient. Stepwise multivariate linear regression analysis was conducted to examine the most important trunk performance variables determining balance confidence. Results Of 177 study participants, the median (IQR) score for TIS 2.0 was 10 (7–12) out of 16 and for balance confidence 41 (27–61) out of 100. Trunk control was highly correlated to overall core muscles strength (r = 0.61–0.70, p <.001) and balance confidence (r = 0.66, p <.001). The major trunk determinants of balance confidence were TIS 2.0 total score (partial R2 = 0.433) and dynamic sitting balance, i.e. trunk lateral flexion (partial R2 = 0.376) in chronic stroke. Conclusion A significant and strong positive association exists among trunk control, core muscles strength and balance confidence in community-dwelling patients with chronic stroke, warranting further investigation of the effect of targeted trunk rehabilitation strategies on functional balance.
Phylogeny of Eumops Miller, 1906 (Chiroptera: Molossidae) Using Morphological Data

Mastiff bats (genus Eumops, family Molossidae) are widely distributed in the neotropics and southern parts of the United States, and form the most taxonomically diverse genus of the family Molossidae with 14 species and six subspecies. The taxonomyof Eumops was treated in two broad studies, and recently, minor taxonomic changes were proposed. Relationships among taxa were historically proposed based on phenetic analyses using biochemical and morphometric data, but a phylogenetic analysis of all species within the genus is lacking. This study proposes a new hypothesis of relationships among most species and subspecies using morphological data and employing cladistic methods. Morphological complexes examined include skull, dentition, tongue, and external morphology; penial data were compiled from literature. The topology of a strict consensus cladogram revealed that one clade is composed of E. perotis + E. trumbulli, and is sister to (E. bonariensis + E. delticus + E. patagonicus + E. nanus + E. hansae in an unresolved polytomy). A second clade is composed of E. underwoodi + E. dabbenei, and a third consists of E. auripendulus and E. maurus, and both are sister to each other. Eumops glaucinus occupies a separate branch in an unresolved polytomy among clades defined above or as sister to E. perotis, E. hansae and E. bonariensis-complex. Results from this study contradict the relationships proposed by previous studies which considered E. auripendulus closer to E. glaucinus, and also disagree with previous outcomes that suggested the non-monophyly of the genus. Results from this study corroborate affinities of E. dabbenei with E. underwoodi, and the uncertain monophyly of E. bonariensis as a polytypic species, supporting the specific status of E. nanus and E. delticus as recently proposed.
Prairie plants harbor distinct and beneficial root-endophytic bacterial communities

Plant-soil feedback studies attempt to understand the interplay between composition of plant and soil microbial communities. A growing body of literature suggests that plant species can coexist when they interact with a subset of the soil microbial community that impacts plant performance. Most studies focus on the microbial community in the soil rhizosphere; therefore, the degree to which the bacterial community within plant roots (root-endophytic compartment) influences plant-microbe interactions remains relatively unknown. To determine if there is an interaction between conspecific vs heterospecific soil microbes and plant performance, we sequenced root-endophytic bacterial communities of five tallgrass-prairie plant species, each reciprocally grown with soil microbes from each hosts’ soil rhizosphere. We found evidence of plant-soil feedbacks for some pairs of plant hosts; however, the strength and direction of feedbacks varied substantially across plant species pairs–from positive to negative feedbacks. Additionally, each plant species harbored a unique subset of root-endophytic bacteria. Conspecifics that hosted similar bacterial communities were more similar in biomass than individuals that hosted different bacterial communities, suggesting an important functional link between root-endophytic bacterial community composition and plant fitness. Our findings suggest a connection between an understudied component of the root-endophytic microbiome and plant performance, which may have important implications in understanding plant community composition and coexistence.
ITQs in Swedish demersal fisheries

Individual transferable quota (ITQ) is a management measure that is widely discussed, not least in the reform of the European Common Fisheries Policy. While the system is expected to reduce overcapacity and improve economic performance, questions are raised concerning the future of small-scale fisheries. This paper uses a model for Swedish fisheries (the Swedish Resource Rent Model for the Commercial Fisheries, SRRMCF) where the economics and fleet structure in a potential Swedish ITQ-system are analysed. The model is an optimization model based on linear programming and data from the European Union's data collection framework. The modelling approach can readily be used by other member states. Three main conclusions can be drawn on how ITQs will affect fisheries: 1. The fishing fleet measured in number of vessels will decrease by approximately 30-50%. 2. Profitability will increase so that the fishing industry will be able to provide competitive wages and make a financial contribution to fisheries management. 3. The system can be designed so that small-scale fisheries are not disadvantaged. (Less)
Comparison of the physical and mental health problems of unemployed with employees in South Korea

Abstract This study compared the physical and mental health problems of adults with standard and nonstandard employment with those who were unemployed. We used data from the Korean National Health and Nutrition Examination Survey to compare adult males and females with standard and nonstandard employment with those who were unemployed. Relative to adults with standard employment, higher proportions of unemployed individuals were women, older, had low monthly incomes, and had mental health problems. Compared to men and women with standard employment, unemployed men and women had greater risk of reporting depressive feelings (OR = 1.683, 95% CI = 1.298–2.183; OR = 1.419, 95% CI = 1.179–1.709) and suicidal ideation (OR = 2.218, 95% CI = 1.682–2.928; OR = 1.250, 95% CI = 1.020–1.530). Among workers with nonstandard employment, there were gender differences in the risk for arthritis. Unemployed individuals also had a higher risk of mental health problems than nonstandard workers. In conclusion, the unemployed were more vulnerable to mental health problems.
Bone Morphogenetic Protein-2 Conjugated to Quantum Dot®s is Biologically Functional

Quantum Dot®s (QDot®s) are novel, semi-conductive nanostructures that emit a certain fluorescence when excited by specific wavelengths. QDot®s are more photostable, brighter, and photobleach less than other fluorescent dyes. These characteristics give them the potential to be used in many biological applications. The shells of QDot®s are coated with functional groups, such as carboxylate and organic groups, allowing them to couple to peptides/proteins and be used for real-time imaging and high-resolution microscopy. Here, we utilize Quantum Dot®s and Bone Morphogenetic Protein-2 (BMP-2) to create a BMP-2-QDot®s conjugate. BMP-2 is a growth factor that drives many processes such as cardiogenesis, neural growth, and osteogenesis. Despite its numerous roles, the trafficking and uptake of BMP-2 into cells is not well-established, especially during progression of diseases. The results presented here demonstrate for the first time a fluorescent BMP-2 analog that binds to the BMP-receptors (BMPRs), remains biologically active, and is stable for long time periods. Previous attempts to develop a biological BMP-2 analog with Fluorescein isothiocyanate (FITC) or nanodiamonds lacked data on the analog’s stability. Furthermore, these analogs did not address whether they can signal within the cell by binding to the BMPRs or were mediated by non-stable conjugates.