Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolic stress and disease-stage specific basigin expression of peripheral blood immune cell subsets in COVID-19 patients

Coronavirus disease 2019 (COVID-19) is driven by dysregulated immune responses yet the role of immunometabolism in COVID-19 pathogenesis remains unclear. By investigating 47 patients with confirmed SARS-CoV-2 infection and 16 uninfected controls, we found an immunometabolic dysregulation specific for patients with progressed disease that was reversible in the recovery phase. Specifically, T cells and monocytes exhibited increased mitochondrial mass, accumulated intracellular ROS and these changes were accompanied by disrupted mitochondrial architecture. Basigin (CD147), but not established markers of T cell activation, was up-regulated on T cells from progressed COVID-19 patients and correlated with ROS accumulation, reflected in the transcriptome. During recovery, basigin and ROS decreased to match the uninfected controls. In vitro analyses confirmed the correlation and showed a down-regulation of ROS by dexamethasone treatment. Our findings provide evidence of a basigin-related and reversible immunometabolic dysregulation in COVID-19.
Response of inorganic fertilizer and biofertilizer on biological yield and quality of hybrid rice (Oryza sativa L.) in indo-gangetic plan of central Uttar Pradesh

A field experiment was conducted on Pot culture house of Department of Soil Science and Agricultural Chemistry at Chandra Shekhar Azad University of Agriculture and Technology, Kanpur during the kharif season 2017, In the present experiment 9 treatments T1 (Control), T2 (100% RDF), T3 (100% RDF+ S40),T4 (100% RDF+Zn5), T5 (100% RDF+ Azotobacter), T6(100% RDF + S40+Azotobacter), T7 (100% RDF + Zn5+Azotobacter), T8 (100% RDF+ S40+ Zn5+Azotobacter), T9 (125% RDF), were laid out in Randomized Block Design(RBD) with four replication. Hybrid rice variety PHB-71 was taken for study. The results revealed that the grain and straw yield of rice respond significantly with the different treatment combination. The highest grain (85.0 q/ha) and straw yield (107.0q/ha) was obtained in) T8 (100% RDF+ S40+ Zn5+Azotobacter). The treatment T8 cause 55.96% increase in hybrid rice grain yield and 62.12% increase in straw yield over control. Quality characteristics of hybrid rice showed that the starch content, protein content in grain and head rice recovery increase with increasing nutrient doses and varied from 67 to 72%, 8.10 to 8.68% and 61 to 71% respectively. The treatment combination T8 (100% RDF+ S40+ Zn5+Azotobacter), gave the best result in terms of yield and crop quality.
Grinnelian and Eltonian niche conservatism of the European honeybee (Apis mellifera) in its exotic distribution

The understanding of how niche-related traits change during species invasion have prompted what is now known as the niche conservatism principle. Most studies that have tested the niche conservatism principle have focused on the extent to which the species’ climatic niches remain stable in their exotic distribution. However, it is equality important to address how biotic specialization, i.e. resource use, changes during exotic species invasions. Here, we use the widespread European honeybee ( Apis mellifera ) to understand whether its Grinnelian and Eltonian niches changed in its exotic distribution using tests of abiotic and biotic niche conservatism. We found that both niche domains of the European honeybee remained stable in its exotic distribution, which means that neither the climatic niche nor the biotic specialization showed significant differences between the native and the exotic ranges. Our findings that climatic and resource use are coupled can be explained by A . mellifera ’s long history of domestication and the possibility that life history traits (e.g., polyandry) may have shaped this species’ large niche over the course of evolution and therefore facilitated exotic ranges colonization.
Antidepressant functions of Jie Yu Chu Fan capsule in promoting hippocampal nerve cell neurogenesis in a mouse model of chronic unpredictable mild stress

Background Depression is a major public health challenge that imposes a great societal burden. Depression has been attributed to the decreased level of neurotransmitters and brain-derived neurotrophic factor (BDNF) levels. Chinese herbal medicine Jie Yu Chu Fan (JYCF) capsule has been shown to be effective in the management of depression. However, the mechanism has yet to be determined. This study aimed to explore the activity of JYCF against depression by establishing a mouse model of chronic unpredictable mild stress (CUMS) with fluoxetine as the positive control drug. Methods The open field test, sucrose preference test, forced swim test, and tail suspension test were carried out to observe the behavioral changes of animals. The levels of norepinephrine (NE), dopamine (DA), and 5-hydroxytryptamine, as well as their respective metabolic products 5-hydroxyindoleacetic acid, homovanillic acid (HVA), and 3,4-dihydroxyphenylacetic acid in the mouse hippocampi were quantified by high-performance liquid chromatography (HPLC). Cell proliferation and apoptosis, and early and mature nerve cells in the hippocampi were observed by immunofluorescence. Reverse transcription polymerase chain reaction was used to identify BDNF expression in the hippocampi. Results After 5 weeks of unpredictable stimulation, a CUMS mouse model was successfully obtained, as indicated by sharply decreased sucrose preference and locomotor activity, as well as an increased immobility time in the forced swim test. Our results demonstrated that treatment with JYCF (1 and 5 g/kg) and fluoxetine (20 mg/kg) dramatically reversed the behavioral abnormalities in CUMS mice. At 1 g/kg, JYCF significantly increased NE, DA, and HVA levels in the hippocampi of CUMS mice. JYCF up-regulated the mRNA expression of BDNF and promoted cell proliferation in hippocampi of CUMS mice. Conclusions Our study demonstrated that JYCF exhibits antidepressant activity comparable to that of fluoxetine in CUMS mice. Moreover, the antidepressant-like activity of JYCF was shown to be mediated by enhancing hippocampal nerve cell neurogenesis through increasing the levels of monoamine neurotransmitters and BDNF expression.
Estudio preliminar de la optimización del proceso de remoción de nitrato de soluciones acuosas utilizando el método de Taguchi / Preliminary study of the process of nitrate removal optimization from aqueous solutions using Taguchi method

One of the most common pollutants in the water is nitrate. High nitrate concentration in water can cause methemoglobinemia in children, and also the formation of carcinogenic nitrosamines. The aim of this study was to optimize the process of nitrate removal from aqueous solutions using the Taguchi method. In this study, the effect of five parameters including adsorbent type, adsorbent amount, contact time, pH and initial concentration of nitrate on nitrate removal efficiency were investigated. The adsorbents used include crushed leaves of palm trees, crushed wheat straw and beech tree wood chips. The range of adsorbents amount used was 1 to 50 g, pH was 5 to 12, the contact time was 1 to 8 hours, and the initial nitrate concentration was 1 to 50 mg/L. The results showed that maximum removal of nitrate was happened with 20 mg/L of initial nitrate concentration at pH = 7, adsorbent mass 30 g and contact time 6 hours. Also, the results showed that nitrate removal efficiency increased with increasing adsorbent mass, initial concentration of nitrate, acidity and contact time to the optimum level, and then decreasing. Also, from the studied adsorbents, crushed leaves of the palm tree have a higher nitrate removal efficiency than other adsorbents.
Effect of different planting density on thermal time use efficiencies and productivity of guar genotypes under southern transition zone of Karnataka

A field experiment was conducted during Kharif seasons of 2014 at University Agricultural and Horticultural Sciences, College of Agriculture, Shivamogga, Karnataka, to study the dry matter accumulation, and various thermal time use efficiencies viz., accumulated growing degree days (GDD), heat use efficiency, helio thermal use efficiency (HTU), photo thermal use efficiency (PTU) of guar cultivars grown under different Planting Density. The guar varieties RGC-1003, HG 365 and RGC 936 were sown with four different planting density viz., 45 cm x 15 cm, 30 cm x 15 cm, 45 cm x 10 cm and 30 cm x 10 cm. the experiment was laid out in RCBD with factorial concept and replicated thrice. The experimental results indicated a high degree of linear relationship between GDD and dry matter accumulation of guar with all the genotype across planting density. among different planting density significantly higher thermal time use efficiencies viz., heat use efficiency (1.82 x10), helio thermal use efficiency (3.47 x10), photo thermal use efficiency (3.73 x10) was recorded with the crop grown in 30 cm x 10 cm of spacing also recorded significantly higher grain yield (898.18 kg ha) and stover yield (1931.39 kg ha) as compared to other spacing. Among genotypes RGC 1003 recorded significantly thermal time use efficiencies viz., heat use efficiency (1.91 x10), helio thermal use efficiency (3.64 x10 ), photo thermal use efficiency (3.90 x10) and grain yield (743.89 kg ha), stover yield (1629.94 kg ha ) as compared to HG 365 and RGC 936.
Physiological basis of cadmium tolerance in groundnut (Arachis hypogaea L.)

Seedlings of thirteen groundnut [Arachis hypogaea L. ] genotypes were raised in sand culture using modified Hoagland solution and were exposed to cadmium stress by supplementing 300 μM cadmium. Perusal of data indicated significant reduction in root dry weight, shoot dry weight and total dry weight of the seedlings under cadmium treatment. The stress tolerance indices (STI) of thirteen genotypes ranged from 65.72% to 93.81% under 300 μM cadmium stress. Among all the genotypes, ISK-2014-04 93.81%), ISK -2014-12and TG-51 were found to be the most tolerant, while the genotypes, ISK-2014-02, ISK-2014-14 and ISK-2014-15 were found to have much lower STI and were considered to be the most susceptible to cadmium stress. Further physiological studies showed that the tolerant genotypes registered much higher increase in proline content, super oxide dismutase (SOD) and guaiacol peroxidase (GPOX) activity in their leaves under cadmium treatment compared to the susceptible ones. But the genotypes exhibited varied response to cadmium stress in respect of catalase (CAT) activity in leaf. The tolerant genotypes also recorded lower reduction in leaf protein content and nitrate reductase (NR) enzyme activity under cadmium treatment.
Fertilization regulates soil enzymatic activity under long term experiments of rice-rice cropping system

Different fertilizers may affect soil enzymatic activity and soil fertility dynamics. These effects were investigated in a long term field experiment with rice-rice cropping system (Oryza sativa L.) at Godavari Alluvials (Vertic chromusters) in Andhra Pradesh. The enzyme activities viz., urease (38.5, 46.2 μg of NH4-N g soil 2h), dehydrogenase (570.1, 596.3 μg of TPF g soil day) and acid (85.36, 87.96 μg pnitrophenol g soil h) and alkaline phosphatase (138.7, 144.8 μg p-nitrophenol g soil h) were significantly higher in treatment T4 (100 % RD of NPK + FYM @ 5 t ha). The enzyme activity of soils, which is governed by microbial population is also significantly higher in INM treatments. Our results demonstrate that soil enzymatic activity acted as a useful indicator of soil fertility dynamics. Enzymatic activities were positively and significantly correlated with content of organic carbon.
The Implications of Misconceptions about Coronavirus Disease (COVID-19) Pandemic in Relation to its Daily Increases from Nigerian Perspective

The outbreak of COVID-19 pandemic in the world especially in African continent and Nigeria in particular has created negative effects on humanity. Continuous holding on to some misconceptions about the reality of the virus among people may create further problems for humankind. However, very few studies particularly in Nigeria have actually considered the implications of these misconceptions about the disease in relation to its daily increases; coupled with the fact that many people still hold on to some of these misconceptions in the country. Therefore, this study examined the implications of some common misconceptions among people about COVID-19 pandemic in relation to its daily increases in Nigeria. This study has documented some of the most common misconceptions about COVID-19 pandemic among few individual persons both male and female in a neighbourhood area of Ibadan in southwestern Nigeria. These include: “it is white people disease”; “it is an imported disease”; “it is the disease of the wealthy people”; “incessant heat in Nigerian environment will destroy the disease (i.e. hot weather)”; “poor people cannot contract it”; “maintaining physical distancing practice is unnecessary”; “taking local herbs will destroy it”; “taking hot drinks (local gins) will destroy it”; “wearing of face masks is not necessary”; etc. both in rural and urban areas. Daily increase in the cases and fatalities of the virus in the country has been suggested in this study to be as a result of tenaciously holding on to these belief-systems among people. Virtually, all sectors in the country such as health, economy, transportation, agriculture, education, security, politics, religion, family, sport, entertainment, etc. have been seriously affected and still being threatened by the virus. Consequently, the negative impacts have been enormous on people’ jobs/works, businesses, family life and social relations thus creating more harms than benefits. Therefore, positive change in people’ health-related behaviours becomes imperative through effective and active public enlightenment and awareness creation with strict compliance to the prescribed preventive measures being put in place by the key stakeholders regarding the virus. This will go a long way in influencing positive health-related behaviours among people, getting rid of some misconceptions about the disease that may trigger larger community transmissions as the efforts to discover new vaccines or drugs for COVID-19 pandemic treatment continue.
University of Kent

The concept of revealed comparative advantage (RCA) stands as a major pillar in empirical trade literature. Yet there is no absolute preference among the suggested RCA measures. Given that these are volume-based indices, results of any relevant empirical analysis would be heavily influenced by the choice of the RCA measure. Considering such an ambiguity, this paper critically evaluates the proposed measures of RCA to identify the ideal measure based on theoretical, statistical and empirical precedence. Its suggested that the Balassa Index and the two corresponding multiplicative normalised variants are more consistent and robust for RCA analysis.
Prevalence and predictors of midwakh smoking among male students of Qassim University, Al-Qassim, Saudi Arabia

INTRODUCTION Novel tobacco products are becoming more popular in the Middle East and especially in Saudi Arabia. We studied the prevalence of midwakh pipe (tobacco smoking pipe) use among students at Qassim University and evaluated factors associated with midwakh pipe usage. METHODS A cross-sectional study was conducted using a self-administered questionnaire to collect the data. The participants were male students from Qassim University, Al-Qassim, Saudi Arabia. Data were collected over the period from May to June 2018. A multivariable logistic regression model was used to identify sociodemographic factors and smoking history related to midwakh smoking. RESULTS A total of 316 responses were collected; 7.9% (n=25) were midwakh smokers at some point, and 3.8% (n=12) were current midwakh smokers. Multivariable logistic regression indicated that the significant predictors of midwakh smoking among male university students were having a friend who is a tobacco or midwakh smoker, and consuming other forms of tobacco other than midwakh. CONCLUSIONS Having midwakh smoking friends, having friends smoking any other form of tobacco, and being a smoker could predict the use of midwakh among university male students in Saudi Arabia. Interventions are required to control this behavior to prevent smoking-related health consequences.
Automating Just-In-Time Comment Updating

Code comments are valuable for program comprehension and software maintenance, and also require maintenance with code evolution. However, when changing code, developers sometimes neglect updating the related comments, bringing in inconsistent or obsolete comments (aka., bad comments). Such comments are detrimental since they may mislead developers and lead to future bugs. Therefore, it is necessary to fix and avoid bad comments. In this work, we argue that bad comments can be reduced and even avoided by automatically performing comment updates with code changes. We refer to this task as “Just-In-Time (JIT) Comment Updating” and propose an approach named CUP (Comment UPdater) to automate this task. CUP can be used to assist developers in updating comments during code changes and can consequently help avoid the introduction of bad comments. Specifically, CUP leverages a novel neural sequence-to-sequence model to learn comment update patterns from extant code-comment co-changes and can automatically generate a new comment based on its corresponding old comment and code change. Several customized enhancements, such as a special tokenizer and a novel co-attention mechanism, are introduced in CUP by us to handle the characteristics of this task. We build a dataset with over 108K comment-code co-change samples and evaluate CUP on it. The evaluation results show that CUP outperforms an information-retrieval-based and a rule-based baselines by substantial margins, and can reduce developers' edits required for JIT comment updating. In addition, the comments generated by our approach are identical to those updated by developers in 1612 (16.7%) test samples, 7 times more than the best-performing baseline.
Role of impaired myocardial relaxation in the production of elevated left ventricular filling pressure

[PDF] [Full Text] [Abstract] , February 1, 2007; 9 (2): 136-143. Eur J Heart Fail G. W. De Keulenaer and D. L. Brutsaert Systolic and diastolic heart failure: Different phenotypes of the same disease? [PDF] [Full Text] [Abstract] , July 1, 2007; 132 (1): 11-17. Chest Twisk, A. Boonstra, P. E. Postmus and A. Vonk-Noordegraaf C. T. -J. Gan, S. Holverda, J. T. Marcus, W. J. Paulus, K. M. Marques, J. G.F. Bronzwaer, J. W. Hypertension Patients Right Ventricular Diastolic Dysfunction and the Acute Effects of Sildenafil in Pulmonary [PDF] [Full Text] [Abstract] , September 1, 2007; 50 (3): 503-511. Hypertension and M. M. Redfield B. P. Shapiro, C. S.P. Lam, J. B. Patel, S. F. Mohammed, M. Kruger, D. M. Meyer, W. A. Linke an Elderly Hypertensive Model Acute and Chronic Ventricular-Arterial Coupling in Systole and Diastole: Insights From [PDF] [Full Text] [Abstract] , April 22, 2008; 117 (16): 2051-2060. Circulation W. Poller, M. Pauschinger, H. -P. Schultheiss and C. Tschope D. Westermann, M. Kasner, P. Steendijk, F. Spillmann, A. Riad, K. Weitmann, W. Hoffmann, Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction [PDF] [Full Text] [Abstract] , December 2, 2009; 30 (24): 3027-3036. Eur. Heart J. P. Steendijk, G. Hasenfuss, C. Tschope and B. Pieske R. Wachter, S. Schmidt-Schweda, D. Westermann, H. Post, F. Edelmann, M. Kasner, C. Luers, relaxation in diastolic heart failure Blunted frequency-dependent upregulation of cardiac output is related to impaired
Haemato-biohemial alterations and comparative efficacy of different therapeutic regimen against trypanosomosis in buffaloes

The present study was conducted to know the haemato-biochemical alternations and to compare the therapeutic efficacy of different anti-trypanosomal drugs in buffaloes. Total of 118 buffaloes of either sex, age group and parity were screened for trypanosomosis. The haematological alternations in the infected buffaloes showed decreased pre treatment values of Hb, PCV, TEC which got increased on 3rd and 7 day post treatment in all the groups. But Erythrocytic indices remained altered with no significance. The mean value of TLC (10/μl) noted markedly decreased on post treatment in all the groups.The biochemical studies revealed no alternation in the mean values of Total protein in all the treated groups on post treatment than the pre treatment mean values 1 day. On the contrary, marked increased mean values of glucose have been obtained on 3 and 7 days post treatment in the T3 group. The AST values found under study were reported to be significantly reduced in all the groups post treatment, but maximum reduction was obtained in T3 groups on day 3 day 7. It was concluded that out of the drugs used isometamidium chloride was found to be most effective as evident by the maximum clinical recovery.
ISSN 2320-5407 International Journal of Advanced Research (2014), Volume 2, Issue 11, 821-827

Aisha Mohamed Samir aishasamir@yahoo.com The actual cause of Parkinson's disease is not known. The disease etiology appears to be multifactorial. The role of environmental factors as manganese toxicity has been proposed in the pathogenesis of Parkinson's disease. Objectives: To detect the association between heavy metals exposure and the effect on nervous system among welders, suggesting the hypothesis that welders are at increased risk for neurological disorders, including Parkinson's disease. Subjects and methodology: Seventy four (74) workers involved in welding process were recruited from four workshops in major industrial facilities in the 10th of Ramadan Industrial area, Cairo Egypt. Full clinical examination for detecting early manifestations of Parkinsonism was performed. Blood levels of heavy metals as manganese; lead, cadmium and Chromium were measured. Results: Parkinsonism manifestations were demonstrated in 11 out of 74 examined subjects. These manifestations revealed statistically significant positive relations with blood levels of lead, manganese and cadmium levels. Conclusion: welders are at increased risk for neurological disorders, including Parkinson's disease. Exposure to heavy metals is a great hazard for developing early Parkinsonism. Recommendations: Environmental control measures should be enforced at the work place. Periodic medical checking for early manifestations of Parkinsonism should be done.
Effect of different levels of phosphorus and biofertilizers (PSB and VAM) on growth and yield of hybrid maize (Zea mays L.)

The field experiment was conducted during kharif season of 2015 at Crop Research Farm SHUATS, Allahabad. The experiment was carried out to find the performance of different Levels of phosphorus and biofertilizers (PSB and VAM) on Growth and Yield of Hybrid Maize, which laid out in Randomized Block Design (RBD) & replicated thrice. The experiment finding revealed that the treatment T9 (80 kg ha P + PSB+VAM) significantly performed better than all other treatments viz; Plant height (187.08 cm), Number of leaves (10.58), while treatment T6 (60 kg ha P + PSB+VAM) performed better than all other treatments viz; Dry weight (51.72 g), Cob length (18.94 cm), Cob weight (241.08 g), Grain yield (4.95 t ha), Straw yield (7.45 t ha), Test weight (28.10 g) and Harvest index (39.98%). While the same treatment T6 (60 kg ha P + PSB+VAM) recorded highest gross return (65653.75 Rs ha), net return (38416.75 Rs ha) and B: C ratio (1.41), however treatment T3 (40 kg ha P + PSB+VAM) was found statistically at par with treatment T6 (60 kg ha P + PSB+VAM).