Miracle-dz/UniFAR-FTUs huggingface dataset:
rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

Background & Aims A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in non-alcoholic fatty liver disease (NAFLD), however, these findings have not been consistently replicated in the literature. We aimed to establish whether rs641738C>T is a risk factor across the spectrum of NAFLD and characterise its role in the regulation of related metabolic phenotypes through meta-analysis. Methods We performed meta-analysis of studies with data on the association between rs641738C>T genotype and: liver fat, NAFLD histology, and serum ALT, lipids, or insulin. These included directly genotyped studies and population-level data from genome-wide association studies (GWAS). We performed random effects meta-analysis using recessive, additive, and dominant genetic models. Results Data from 1,047,265 participants (8,303 with liver biopsies) across 42 studies was included in the meta-analysis. rs641738C>T was associated with higher liver fat on CT/MRI (+0.03 standard deviations [95% CI: 0.02 - 0.05]) and diagnosis of NAFLD (OR 1.22 [95% CI 1.08 - 1.39]) in Caucasian adults. The variant was also positively associated with presence of severe steatosis, NASH, and advanced fibrosis (OR: 1.32 [95% CI: 1.06 - 1.63]) in Caucasian adults using a recessive model of inheritance (CC+CT vs. TT). Meta-analysis of data from previous GWAS found the variant to be associated with higher ALT (Pz=0.002) and lower serum triglycerides (Pz=1.5x10-4). rs641738C>T was not associated with fasting insulin and no effect was observed in children with NAFLD. Conclusion Our study validates rs641738C>T near MBOAT7 as a risk factor for the presence and severity of NAFLD in individuals of European descent.
Cardiovascular dysfunction in patients of cirrhosis of liver

Background: Cirrhosis of liver refers to a progressive condition that disrupts the normal architecture of the liver. It is increasingly recognized that cirrhosis per se can cause cardiac dysfunction. The aim was to assess cardiovascular dysfunction electrocardiographically and echocardiographically in patients with cirrhosis of liver and to find the correlation between cardiovascular dysfunction and severity of liver cirrhosis as per child-PUGH score. Methods: Total 90 patients of cirrhosis of liver of both sexes were included in this cross-sectional study conducted from January 2018 to August 2019 in SGRDIMSR, Sri Amritsar. The severity of liver cirrhosis was assessed as per Child Pugh Score. QTc interval was calculated by Bazett’s formula. Systolic and Diastolic dysfunction was seen on 2D-echocardiography. Results: QTc interval increased linearly with the severity of liver cirrhosis. Mean values of QTc in Child Pugh Class A=425.00(±20.97), Class B=437.35(±42.60), Class C=479.71(±29.48) with p value of 0.04 which is significant. Diastolic dysfunction was also related with the severity of liver cirrhosis. In Child Pugh Class A= 2(33%) patients had grade 1 diastolic dysfunction, Class B=23(59%) patients had grade 1 diastolic dysfunction while in Child Pugh Class C=3(7%) had grade 1 diastolic dysfunction, 33(73%) patients had grade 2 diastolic dysfunction and 1(2%) patients had grade 3 diastolic dysfunction with p value of 0.04 which is significant. Systolic function was found normal in all the patients. Conclusions: Diastolic dysfunction and QTc interval prolongation are both related with the severity of liver cirrhosis and are major criteria of cirrhotic cardiomyopathy.
Content Counts and Motivation Matters: Reading Comprehension in Third-Grade Students Who Are English Learners

This study examined the role of science domain knowledge, reading motivation, and decoding skills in reading comprehension achievement in third-grade students who are English learners (ELs) and students who are monolingual, using a nationally representative data set. Multigroup probit regression analyses showed that third-grade science domain knowledge and motivation for reading, decoding skills, and early attainment of decoding skills were significantly associated with third-grade reading comprehension in both language groups. Also, using Wald chi-square tests, the study showed that the association between third-grade science domain knowledge and reading comprehension was stronger in students who were ELs than in students who were monolingual. These findings suggest that cultivating science domain knowledge is very important to supporting reading comprehension development in third grade, particularly for students who are ELs.
Challenge Course Activities and Orientation for Master’s Level Counseling Students: A Qualitative Exploration

ABSTRACT Orientation is an important component of a student’s transition to beginning a counselor preparation program. In this study, the researchers conducted interviews with 16 students to explore the use of challenge course activities, involving group games, within the orientation process. The researchers identified three overarching themes (process of getting to know each other, application, and recommendations) and multiple subthemes. The researchers also discuss the limitations and recommendations for future research, as well as the implications for counselor education.
From incidental exposure to intentional avoidance: Psychological reactance to political communication during the 2017 German national election campaign

This article deals with potential effects of incidental online exposure to political information (IOEP) on the German electorate during the 2017 national election campaign. We argue that the difference in currently unexpected and generally unwanted exposure to political online communication is crucial to the study of IOEP effects. While the former might result in “passive learning,” we hypothesize that–based on psychological reactance theory–the latter may be linked to defensive reactions with undesirable consequences among those who already are alienated from politics. Using cross-sectional data from an online survey among 1100 eligible voters, we can demonstrate that IOEP correlates with reactance in substantial segments. The study’s results are indicating, that the viral character of online campaigning may lead to the opposite of what was intended: voters are not only “trapped,” but might be repelled instead. Further empirical elaboration dealing with causal assumptions is encouraged.
Experimental investigation on shear resistance of self-consolidating concrete beams

Abstract Self-consolidating concrete stands out for its high fluidity and stability, which are obtained by the reduction of the coarse aggregate dimensions and content in the mixture and also by the addition of superplasticizer and viscosity modifiers. An experimental test program was carried out to evaluate the influence of these particularities of self-consolidating concrete mixtures on the shear capacity of beams with shear reinforcement. Four mixtures of self-compacting concrete and two mixtures of conventionally vibrated concrete with different coarse aggregate size and volume were used for the production of beams to be tested under flexure. The experimental results were compared to those estimated by the ACI-318, CAN A23.3, EC-2 and NBR 6118 design codes. The results demonstrated that the reduction of coarse aggregate dimensions and content in self-compacting concrete mixture did not significantly influence the ultimate shear strength. The shear strengths obtained experimentally were considered adequate to codes estimates, for both concrete types.
Atmospheric Diffusivity: A New Energetic Framework for Understanding the Midlatitude Circulation Response to Climate Change

The midlatitude circulation response to climate change is not well understood. Within an energetic framework the circulation is connected to the atmospheric diffusivity. Here we define a novel diagnostic diffusivity framework as a tool for interpreting changes in the midlatitude atmospheric circulation. The diffusivity is computed by dividing the zonally and vertically integrated transient eddy moist static energy (MSE) transport by the zonal‐mean 925 hPa MSE gradient, and we investigate the diffusivity response to global‐scale sea surface temperature (SST) perturbations in aquaplanet and Atmospheric Model Intercomparison Project (AMIP) general circulation model simulations. The midlatitude diffusivity maximum shifts poleward with increasing SST in both the aquaplanet simulations and Southern Hemisphere winter of the AMIP simulations. Our framework indicates that this diffusivity shift is associated with Ferrel circulation and 925 hPa MSE gradient changes, rather than with total MSE transport changes. The MSE gradient‐related shift cannot be understood purely in terms of Clausius‐Clapeyron changes in specific humidity following the global‐mean temperature response, because atmospheric temperature gradients change significantly even when SST gradients are held fixed. The intensity of the diffusivity maximum also increases with SST for the aquaplanet configuration but is relatively insensitive to SST for AMIP Southern Hemisphere winter. Additional energy balance model experiments suggest that while diffusivity changes caused by SST perturbations can be large, their effect on zonal‐mean temperature is minor. Finally, the latitudes and intensities of the diffusivity maxima are strongly correlated with the same properties of the zonal‐mean eddy kinetic energy maxima. However, existing theories cannot adequately explain these linear relationships.
Relationship between work ability and mental workload with musculoskeletal disorders in industrial jobs

Introduction: Subjective workload is a general concept in ergonomics literature, defined as the costs to the operator's health to achieve a certain level of performance. On the other hand early withdrawal of workers from work has increased the problems of today's industries. In this regard Promotion of workers ability is one of the most effective ways to prevent the disability. The purpose of this study is to determine the relationship between work ability and mental work load with musculoskeletal disorders among workers in a steel industry. Methods: This descriptive cross-sectional study was carried out on 300 workers from various occupational groups in a steel industry. The Persian version of NASA-TLX questionnaire, work ability index questionnaire, and Nordic Questionnaire were used for data collection. Collected Data were analyzed using to SPSS ver. 20 Software . Independent t-test and Mann-Whitney were used. Results: Independent t-test showed a significant relationship between the musculoskeletal disorders and work ability of workers (P<.001). Also Mann-Whitney test showed a significant relationship between the musculoskeletal disorders and total workload, dimensions of effort, temporal demand, frustration, mental demand and physical demand (P<0.001, P=0.004, P=0.005, P=0.022, P=0.024, respectively). Significant relationship was observed between the workers musculoskeletal disorders and performance dimension (P=0.087). Conclusion: Mental workload of workers was high and their work ability was at an intermediate level. Based on the relationship between workload and work ability with musculoskeletal disorders, creating perfect job conditions, Providing training programs for employees and increasing workers ability can contribute to prevention of musculoskeletal disorders.
Depth and temperature preference of anadromous Arctic char Salvelinus alpinus in the Kitikmeot Sea, a shallow and low-salinity area of the Canadian Arctic

The Arctic climate is changing rapidly, yet predicting how aquatic species will respond to these changes remains challenging given the lack of empirical data for most highlatitude taxa. Acoustic telemetry has recently emerged as an important methodology for understanding horizontal and vertical space-use patterns in fishes. Here, we used acoustic telemetry to document marine habitat use and depth/temperature preference of 26 anadromous Arctic char Salve linus alpinus within the Kitikmeot Sea region of the Canadian central Arctic over 4 yr (2013− 2016). Most detections (~70%) were within the top 3 m of the water column, and most were in estuarine (72.6%) vs. marine (27.4%) habitats. Arctic char preferred deeper waters later in the summer, but the temperature they occupied remained relatively constant throughout the marine feeding season (~5−8°C). Most Arctic char exhibited some degree of repetitive diving behavior, with individuals diving to 35 m. Diving activity increased later in the summer marine feeding season and is likely a response to the seasonal transition of their preferred prey to deeper waters as the season progresses. Finally, Arctic char preferred deeper waters with less ice cover and during the day, the latter suggesting potential diel patterns to marine habitat use. Finally, year-to-year variation in Arctic char depth and temperature use was very modest despite differences in climatic and ice conditions. This result suggests that habitat use is relatively fixed and may reflect their thermal and osmoregulatory physiology, which has important implications for forecasting the impacts of a changing Arctic on this economically valuable species.
Sensory and Chemical Changes of Cold and Hot Brew Arabica Coffee at Various Resting Time

Coffee is one of the most popular beverages which are rich in sensory attributes. What is the best time for brewing coffee after roasting is important question for consumer. In general, people do not directly brew coffee that has just been roasted. The chemical change which causes sensory changes still continues during the resting time. Enjoying coffee is about taste, everyone has different preferences. Some people prefer bitter coffee; some people like the sour taste and some others consume sweet coffee. Therefore, information about sensory and chemical profile is needed to give several options for consumer to choose their brewing method and brewing time before the coffee has decreased in sensory quality. This current study aims to know sensory and chemical changes of cold and hot brew Arabica coffee at various resting time. The materials were coffee beans Arabica Jawa Gunung Halu obtained from Cibeber, Sidangkerta Village, Mekarsari District, Bandung Regency, West Java. The roasted bean stored at various resting time (1, 3, 5, 7, and 9 days) than brewed in cold and hot brew methods. Sensory evaluation was conducted by 10 trained panelists using quantitative descriptive analysis (QDA). Furthermore, chemical analyses which were evaluated consist of the value of pH, brix and Total Dissolved Solid (TDS). The results showed that longer resting time followed by sensory characteristics changes on aroma, after taste, sweetness that is in line with chemical attributes change in Brix. Moreover color change in line with TDS change. While the different brewing techniques show that hot brew has higher value than cold brew in most all of parameters except Brix value. Keywords — chemical, coffee, panelists , resting time, sensory
KIR3DL1 Interaction with HLA-B27 is Altered by ERAP1 and Enhanced by MHC Class I Cross-linking

Ankylosing Spondylitis (AS) is an inflammatory arthritis linked to the antigen presenting molecule HLA-B27. The risk of AS is increased in patients possessing endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphisms, rs30187 and rs27044, encoding amino acid changes K528 and Q730, respectively. Dysfunction of ERAP1 is hypothesized to cause changes in expression of HLA-B27 peptide-HLA trimer (pHLA) and free heavy chain (FHC) ligands, on antigen presenting cells (APCs), which interact with natural killer (NK) cell receptor, KIR3DL1. Dysregulation of this pathway may be pathogenic in AS. APC cell lines expressing HLA-B27 were found to inhibit cytokine production of KIR3DL1+ NK cells due to decreased APC-NK cell adhesion and possibly activating receptor down-regulation. Blocking pHLA and FHC reveals both conformers inhibit cytokine production through KIR3DL1. KIR3DL1 affinity and HLAB27 surface expression studies suggest ERAP1 R528 and E730 expression protects from AS by generating sub-optimal pHLA, causing reduced KIR3DL1 affinity and weaker cytokine
Joint effect of peroxisome proliferator-activated receptor c genetic polymorphisms and estrogen-related risk factors on breast cancer risk: results from a case-control study in Taiwan

Peroxisome proliferator-activated receptor c (PPARc) has been linked with possible antineoplastic effects in colorectal carcinogenesis. However, data for the possible link between PPARc and breast cancer risk are sparse. We assessed the association of three polymor- phisms in PPARc (rs10865710 (C-681T), rs1805192 (Pro12Ala), and rs3856806 (C1431T)) with the risk of breast cancer in an ethnic Chinese female population in Taiwan. In addition, interactions with estrogen exposures were also explored. Genotypes for the PPARc polymor- phisms were determined on 291 incident breast cancer cases and 589 matched controls by fluorogenic 5 0 -nuclease assay. The at-risk haplotypes were defined according to the
Effect on Lipid Profile Parameters by the Addition of Orange Juice in Dietof Hypercholesterolemic Patients

Proceedings of epidemiologic data revealed that a more consumption of vegetable and fruits allied with a less susceptibility of Acute Heart Disease. Orange juice is a good source of folate, Vitamin C and flavanones, but their effect on heart patients has not been studied scrupulously. Present research focused on fifty subjects having elevated total cholesterol and LDL cholesterol. Participants consumed 2 cups (5000 mL) of orange juice daily into their diets, each dose over a period of 4 week followed by a 5-week washout period. Plasma lipid, folate and vitamin C (a compliance marker) concentrations measured at baseline, after each treatment, and after the washout period. The consumption of calcium, fatty acids, protein total energy and cholesterol did not significantly varied in each of the period. The dietary interference had no substantial effect on body weight body mass index or plasma lipid concentration. Though total plasma triglycerol and HDL-cholesterol concentration increased 17% and 24% however LDL-HDL cholesterol ratio declined during the study time period.
Considerations for Chemotherapy Treatment in Platinum Resistant High-Grade Serous Ovarian Cancer

Ovarian cancer is considered to be the most fatal type of any gynecological cancer. Prognosis for the disease is poor, with a median survival of only thirty-two months following diagnosis and a five-year survival rate of only 39%. Many of the most lethal ovarian cancer cases are classified as part of the high-grade serous ovarian cancer (HGSOC) subtype, which is the most aggressive form of the disease. The primary concern with regards to treatment is that nearly 30% of patients will develop a resistance to forms of platinum chemotherapy, which is the main method of treatment. This suggests that a one-size fits all approach cannot be taken to treat ovarian cancer, and that further research must be done to understand how to treat the patients who present with platinum resistance. This literature review examines the mutations within two susceptible loci, specifically, the p53 and BRCA1/2 genes, in order to understand how platinum resistance develops and why it is present in some patients. The objectives of this review are to characterize the underlying genetic mechanisms affecting platinum resistance, specify the biomarkers associated with those mechanisms, and describe alternative methods for approaching the treatment of ovarian cancer on an individual scale.
Meteorological Imagery for the Geostationary Lightning Mapper

The Geostationary Lightning Mapper (GLM) on the Geostationary Operational Environmental Satellite‐R series of weather satellites provides point geolocations of lightning flashes that are further comprised of a hierarchy of geolocated groups and events. This study describes an open‐source method for reconstruction of imagery from those point detections that retains the quantitative physical measurements made by GLM, restores the spatial footprint of the events, and connects that spatial footprint to the groups and flashes. Meteorological signals are demonstrated to be more apparent in the gridded imagery than in the point detections, leading to their adoption by the United States National Weather Service as the first GLM product available in their real‐time displays. Analysis of a mesoscale convective system over Argentina confirms that there is a class of propagating lightning observed by GLM (distinct from that in storm cores) that can be visualized and quantified using our imagery‐based approach.
Minimizing cancer's impact on bone with denosumab: Current and future perspectives

Bone metastasis is a serious complication of advanced cancer. It is most commonly observed in patients with metastatic breast and prostate cancers, but also occurs in most other metastatic solid cancers. Without treatment, patients may experience complications including intractable bone pain, hypercalcemia, fracture, spinal cord compression and/or a requirement for surgical or radiotherapeutic intervention. In 2010, denosumab, a fully human monoclonal antibody that inhibits RANK ligand (RANKL) and subsequent osteoclast-mediated bone destruction, was approved by the Food and Drug Administration for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. This article reviews the role of denosumab in preventing SREs due to bone metastases, treating bone loss due to hormone-ablative cancer therapies, and describes denosumab’s safety profile and potential future indications under investigation.
Peak expiratory flow rate in healthy school children

Background: Peak expiratory flow rate (PEFR) assesses the overall functional status of the respiratory system. Aims and Objectives: The aim of this study was to observe the PEFR in school going healthy children, in a town located in the southern part of India. To illustrate the relation among the age, height, weight, and PEFR in the school going children. Materials and Methods: 119 school going healthy boys were selected randomly, aged between 5 and 16 years. Anthropometric parameters, namely, height and weight of the subjects were measured to the nearest reading with minimal clothes on and without footwear using stadiometer and weighing machine, respectively. Subjects were divided into five groups: Group I with a height range of 101-120 cm, Group II with 121-130 cm; Group III with 131-140 cm; Group IV with 141-150 cm; and Group V with 151-160 cm. PEFR was measured using the pocket flow meter and wrights flow meter. Results: Mean PEFR values with standard deviation in the five groups with pocket flow meter and with wrights flow meter are Group I: 159 ± 18.3 and 118 ± 22.5, Group II: 227 ± 31.0 and 204 ± 31.8, Group III: 253 ± 52.0 and 234 ± 51.2, Group IV: 309 ± 43 and 296 ± 40.9, and Group V: 368 ± 51.0 and 343 ± 47.7. Correlation coefficient was also calculated between the height and PEFR, measured with pocket flow meter in all the five groups; 0.64, 0.68, 0.25, 0.47, and 0.69 from Groups I to V. Conclusion: PEFR is increased with the increasing in height of the subjects.