Miracle-dz/UniFAR-FTUs huggingface dataset:
Habituation Reflects Optimal Exploration Over Noisy Perceptual Samples

From birth, humans constantly make decisions about what to look at and for how long. Yet, the mechanism behind such decision-making remains poorly understood. Here, we present the rational action, noisy choice for habituation (RANCH) model. RANCH is a rational learning model that takes noisy perceptual samples from stimuli and makes sampling decisions based on expected information gain (EIG). The model captures key patterns of looking time documented in developmental research: habituation and dishabituation. We evaluated the model with adult looking time collected from a paradigm analogous to the infant habituation paradigm. We compared RANCH with baseline models (no learning model, no perceptual noise model) and models with alternative linking hypotheses (Surprisal, KL divergence). We showed that (1) learning and perceptual noise are critical assumptions of the model, and (2) Surprisal and KL are good proxies for EIG under the current learning context.
HISTONE DEACETYLASE 9 transduces heat signal in plant cells

Significance Understanding how plant cells sense and transduce heat signals has critical implications for improving plant heat tolerance. Here, we demonstrate that under heat stress, the phosphatase PP2AB′β dephosphorylates and stabilizes the histone deacetylase HDA9 in the cytoplasm. The nucleoporin HOS1 then translocates HDA9 into the nucleus, where the zinc-finger transcription factor YY1 helps recruit it to target genes to regulate gene expression via histone deacetylation. The cytoplasm-to-nucleus translocation of HDA9 in response to heat is conserved in wheat and rice. Thus, we identified a mechanism by which plant cells transduce heat signals from the cytoplasm to the nucleus and regulate gene expression, which could be used for crop improvement.
Contextual factors and spatial trends of childhood malnutrition in Zambia

Background Understanding the national burden and epidemiological profile of childhood malnutrition is central to achieving both national and global health priorities. However, national estimates of malnutrition often conceal large geographical disparities. This study examined the prevalence of childhood malnutrition across provinces in Zambia, changes over time, and identified factors associated with the changes. Methods We analyzed data from the 2013/4 and 2018 Zambia demographic and health surveys (ZDHS) to examine the spatial heterogeneity and mesoscale correlates of the dual burden of malnutrition in children in Zambia. Maps illustrating the provincial variation of childhood malnutrition were constructed. Socio-demographic and clinical factors associated with childhood malnutrition in 2013 and 2018 were assessed independently using a multivariate logistic model. Results Between 2013/4 and 2018, the average prevalence of stunting decreased from 40.1% (95% CI: 39.2–40.9) to 34.6% (95% CI:33.6–35.5), wasting decreased from 6.0% (95% CI: 5.6–6.5) to 4.2% (95% CI: 3.8–4.7), underweight decreased from 14.8% (95% CI: 14.1–15.4) to 11.8% (95% CI: 11.2–12.5) and overweight decreased from 5.7% (95% CI: 5.3–6.2) to 5.2% (95% CI: 4.8–5.7). High variability in the prevalence of childhood malnutrition across the provinces were observed. Specifically, stunting and underweight in Northern and Luapula provinces were observed in 2013/14, whereas Lusaka province had a higher degree of variability over the two survey periods. Conclusion The study points to key sub-populations at greater risk and provinces where malnutrition was prevalent in Zambia. Overall, these results have important implications for nutrition policy and program efforts to reduce the double burden of malnutrition in Zambia.
Elucidating the cellular uptake mechanisms of heptamethine cyanine dye analogues for their use as an anticancer drug‐carrier molecule for the treatment of glioblastoma

The development of chemotherapies for glioblastoma is hindered by their limited bioavailability and toxicity on normal brain function. To overcome these limitations, we investigated the structure‐dependent activity of heptamethine cyanine dyes (HMCD), a group of tumour‐specific and BBB permeable near‐infrared fluorescent dyes, in both commercial (U87MG) and patient‐derived GBM cell lines. HMCD analogues with strongly ionisable sulphonic acid groups were not taken up by patient‐derived GBM cells, but were taken up by the U87MG cell line. HMCD uptake relies on a combination of transporter uptake through organic anion‐transporting polypeptides (OATPs) and endocytosis into GBM cells. The uptake of HMCDs was not affected by p‐glycoprotein efflux in GBM cells. Finally, we demonstrate structure‐dependent cytotoxic activity at high concentrations (EC50: 1–100 μM), likely due to mitochondrial damage‐induced apoptosis. An in vivo orthotopic glioblastoma model highlights tumour‐specific accumulation of our lead HMCD, MHI‐148, for up to 7 days following a single intraperitoneal injection. These studies suggest that strongly ionisable groups like sulphonic acids hamper the cellular uptake of HMCDs in patient‐derived GBM cell lines, highlighting cell line‐specific differences in HMCD uptake. We envisage these findings will help in the design and structural modifications of HMCDs for drug‐delivery applications for glioblastoma.
Recursive sequence generation in crows

Recursion, the process of embedding structures within similar structures, is often considered a foundation of symbolic competence and a uniquely human capability. To understand its evolution, we can study the recursive aptitudes of nonhuman animals. We adopted the behavioral protocol of a recent study demonstrating that humans and nonhuman primates grasp recursion. We presented sequences of bracket pair stimuli (e.g., [ ] and { }) to crows who were instructed to peck at training lists. They were then tested on their ability to transfer center-embedded structure to never-before-seen pairings of brackets. We reveal that crows have recursive capacities; they perform on par with children and even outperform macaques. The crows continued to produce recursive sequences after extending to longer and thus deeper embeddings. These results demonstrate that recursive capabilities are not limited to the primate genealogy and may have occurred separately from or before human symbolic competence in different animal taxa.
The Application of Graph Theoretical Analysis to Complex Networks in Medical Malpractice in China: Qualitative Study

Background Studies have shown that hospitals or physicians with multiple malpractice claims are more likely to be involved in new claims. This finding indicates that medical malpractice may be clustered by institutions. Objective We aimed to identify the underlying mechanisms of medical malpractice that, in the long term, may contribute to developing interventions to reduce future claims and patient harm. Methods This study extracted the semantic network in 6610 medical litigation records (unstructured data) obtained from a public judicial database in China. They represented the most serious cases of malpractice in the country. The medical malpractice network of China was presented as a knowledge graph based on the complex network theory; it uses the International Classification of Patient Safety from the World Health Organization as a reference. Results We found that the medical malpractice network of China was a scale-free network—the occurrence of medical malpractice in litigation cases was not random, but traceable. The results of the hub nodes revealed that orthopedics, obstetrics and gynecology, and the emergency department were the 3 most frequent specialties that incurred malpractice; inadequate informed consent work constituted the most errors. Nontechnical errors (eg, inadequate informed consent) showed a higher centrality than technical errors. Conclusions Hospitals and medical boards could apply our approach to detect hub nodes that are likely to benefit from interventions; doing so could effectively control medical risks.
Abundances and Depletions of Neutron-capture Elements in the Interstellar Medium

We present an extensive analysis of the gas-phase abundances and depletion behaviors of neutron-capture elements in the interstellar medium (ISM). Column densities (or upper limits to the column densities) of Ga ii, Ge ii, As ii, Kr i, Cd ii, Sn ii, and Pb ii are determined for a sample of 69 sight lines with high- and/or medium-resolution archival spectra obtained with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope. An additional 59 sight lines with column density measurements reported in the literature are included in our analysis. Parameters that characterize the depletion trends of the elements are derived according to the methodology developed by Jenkins. (In an appendix, we present similar depletion results for the light element B.) The depletion patterns exhibited by Ga and Ge comport with expectations based on the depletion results obtained for many other elements. Arsenic exhibits much less depletion than expected, and its abundance in low-depletion sight lines may even be supersolar. We confirm a previous finding by Jenkins that the depletion of Kr increases as the overall depletion level increases from one sight line to another. Cadmium shows no such evidence of increasing depletion. We find a significant amount of scatter in the gas-phase abundances of Sn and Pb. For Sn, at least, the scatter may be evidence of real intrinsic abundance variations due to s-process enrichment combined with inefficient mixing in the ISM.
Centrality Dependence of Bulk Fireball Properties at RHIC

We explore the centrality dependence of the properties of the dense hadronic matter created in p sNN = 200GeV Au–Au collisions at RHIC. Using the statistical hadronization model, we fit particle yields known for 11 centrality bins. We present the resulting model parameters, rapidity yields of physical quantities, and the physical properties of bulk matter at hadronization as function of centrality. We discuss the production of strangeness and entropy.
Endometriosis and pregnancy: The illusion of recovery

The objective of this study was to investigate the feelings and experiences of infertile women with deep infiltrating endometriosis during and after a first pregnancy achieved by in-vitro fertilization (IVF). We conducted a qualitative monocentric study between May and November 2020. Semi-structured interviews were undertaken with infertile women with deep infiltrating endometriosis who achieved a first pregnancy by IVF and delivered at least two years prior to the interview. Data analysis was performed using an inductive approach to identify recurrent categories and themes. Fifteen interviews were conducted to reach data saturation. Pregnancy appeared to improve all components of the experience of endometriosis that were explored (psychological and physical well-being, social relationships, professional life, and sexuality). This improvement was only temporary and all symptoms and negative aspects of the women’s quality of life reappeared after a variable period.
Pharmacotherapy of LAMA/LABA inhaled therapy combinations for chronic obstructive pulmonary disease: a clinical overview

ABSTRACT Introduction Long-acting muscarinic receptor antagonist (LAMA)/β2-agonist (LABA) combinations represent a significant improvement in the treatment of chronic obstructive pulmonary disease (COPD) due to their remarkable ability to improve lung function, dyspnea, quality of life, and exercise capacity compared to mono-components. Areas covered This article aims to report the latest information on the clinical impact of dual bronchodilation in COPD. Expert opinion The available data supports the use of inhaled LAMA/LABA FDCs in treating COPD patients, particularly those with severe or very severe disease. These combinations provide short – and long-term benefits to COPD patients without increasing the dose of the single components, which reduces the risk of adverse events while ensuring an improvement in clinical efficacy. Unfortunately, head-to-head studies comparing all exiting LABA/LAMA combinations are relatively few. Since each available LAMA/LABA combination has a unique efficacy/safety profile that must be considered for personalized COPD therapy, further randomized controlled trials and real-world studies lasting at least one year are needed to assess what differences, if any, there are in terms of clinical outcomes when dual LAMA/LABA inhalers are compared to LAMA or LABA single inhalers, and to compare different LAMA/LABA FDCs.
High‐throughput immunoaffinity enrichment and N‐glycan analysis of human plasma haptoglobin

Haptoglobin (Hp) is a positive acute phase protein, synthesized in the liver, with four N‐glycosylation sites carrying mainly complex type N‐glycans. Its glycosylation is altered in different types of diseases but still has not been extensively studied mainly due to analytical challenges, especially the lack of a fast, efficient, and robust high‐throughput Hp isolation procedure. Here, we describe the development of a high‐throughput method for Hp enrichment from human plasma, based on monolithic chromatographic support in immunoaffinity mode and downstream Hp N‐glycome analysis by hydrophilic interaction ultrahigh‐performance liquid chromatography with fluorescent detection (HILIC–UHPLC–FLR). Chromatographic monolithic supports in a 96‐well format enable fast, efficient, and robust Hp enrichment directly from diluted plasma samples. The N‐glycome analysis demonstrated that a degree of Hp deglycosylation differs depending on the conditions used for N‐glycan release and on the specific glycosylation site, with Asn 241 being the most resistant to deglycosylation under tested conditions. HILIC–UHPLC–FLR analysis enables robust quantification of 28 individual chromatographic peaks, in which N‐glycan compositions were determined by UHPLC coupled to electrospray ionization quadrupole time of flight mass spectrometry. The developed analytical approach enables fast evaluation of total Hp N‐glycosylation and is applicable in large‐scale studies.
Implementation of the I-PASS handoff program in diverse clinical environments: A multicenter prospective effectiveness implementation study.

BACKGROUND Handoff miscommunications are a leading source of medical errors. Harmful medical errors decreased in pediatric academic hospitals following implementation of the I-PASS handoff improvement program. However, implementation across specialties has not been assessed. OBJECTIVE To determine if I-PASS implementation across diverse settings would be associated with improvements in patient safety and communication. DESIGN Prospective Type 2 Hybrid effectiveness implementation study. SETTINGS AND PARTICIPANTS Residents from diverse specialties across 32 hospitals (12 community, 20 academic). INTERVENTION External teams provided longitudinal coaching over 18 months to facilitate implementation of an enhanced I-PASS program and monthly metric reviews. MAIN OUTCOME AND MEASURES Systematic surveillance surveys assessed rates of resident-reported adverse events. Validated direct observation tools measured verbal and written handoff quality. RESULTS 2735 resident physicians and 760 faculty champions from multiple specialties (16 internal medicine, 13 pediatric, 3 other) participated. 1942 error surveillance reports were collected. Major and minor handoff-related reported adverse events decreased 47% following implementation, from 1.7 to 0.9 major events/person-year (p < .05) and 17.5 to 9.3 minor events/person-year (p < .001). Implementation was associated with increased inclusion of all five key handoff data elements in verbal (20% vs. 66%, p < .001, n = 4812) and written (10% vs. 74%, p < .001, n = 1787) handoffs, as well as increased frequency of handoffs with high quality verbal (39% vs. 81% p < .001) and written (29% vs. 78%, p < .001) patient summaries, verbal (29% vs. 78%, p < .001) and written (24% vs. 73%, p < .001) contingency plans, and verbal receiver syntheses (31% vs. 83%, p < .001). Improvement was similar across provider types (adult vs. pediatric) and settings (community vs. academic).
HIGH-SPEED TRANSITION REGION AND CORONAL UPFLOWS IN THE QUIET SUN

We study the line profiles of a range of transition region (TR) emission lines observed in typical quiet-Sun regions. In magnetic network regions, the Si iv 1402 Å, C iv 1548 Å, N v 1238 Å, O vi 1031 Å, and Ne viii 770 Å spectral lines show significant asymmetry in the blue wing of the emission line profiles. We interpret these high-velocity upflows in the lower and upper TR as the quiet-Sun equivalent of the recently discovered upflows in the low corona above plage regions. The latter have been shown to be directly associated with high-velocity chromospheric spicules that are (partially) heated to coronal temperatures and play a significant role in supplying the active region corona with hot plasma. We show that a similar process likely dominates the quiet-Sun network. We provide a new interpretation of the observed quiet-Sun TR emission in terms of the relentless mass transport between the chromosphere and corona—a mixture of emission from dynamic episodic heating and mass injection into the corona as well as that from the previously filled, slowly cooling, coronal plasma. Analysis of the observed upflow component shows that it carries enough hot plasma to play a significant role in the energy and mass balance of the quiet corona. We determine the temperature dependence of the upflow velocities to constrain the acceleration and heating mechanism that drives these upflows. We also show that the temporal characteristics of these upflows suggest an episodic driver that sometimes leads to quasi-periodic signals. We suggest that at least some of the quasi-periodicities observed with coronal imagers and spectrographs that have previously been interpreted as propagating magnetoacoustic waves, may instead be caused by these upflows.
High-resolution imaging of the He II λ4686 emission line nebula associated with the ultraluminous X-ray source in Holmberg II

We present Hubble Space Telescope images of the Heiii region surrounding the bright X-ray source in the dwarf irregular galaxy Holmberg II. Using Chandra, we find a position for the X-ray source of � = 08h 19m 28.98s, � = +70 ◦ 42 ' 19. '' 3 (J2000) with an uncertainty of 0.6 '' . We identify a bright, point-like optical counterpart centered in the nebula with the X-ray source. The optical magnitude and color of the counterpart are consistent with a star with spectral type between O4V and B3 Ib at a distance of 3.05 Mpc or reprocessed emission from an X-ray illuminated accretion disk. The nebular Heii luminosity is 2.7×10 36 ergs −1 . The morphology of the Heii, H�, and (Oi) emission are consistent with being due to X-ray photoionization and are inconsistent with narrow beaming of the X-ray emission. A spectral model consisting of a multicolor disk blackbody with inverse-Compton emission from a hot corona gives a good fit to X-ray spectra obtained with XMM-Newton. Using the fitted X-ray spectrum, we calculate the relation between the Heii and X-ray luminosity and find that the Heii flux implies a lower bound on the X-ray luminosity in the range 4 to 6× 10 39 ergs −1 if the extrapolation of the X-ray spectrum between 54 eV and 300 eV is accurate. A compact object mass of at least 25 to 40M⊙ would be required to avoid violating the Eddington limit.
Individual costs and community benefits: Collectivism and individuals’ compliance with public health interventions

Differences in national responses to COVID-19 have been associated with the cultural value of collectivism. The present research builds on these findings by examining the relationship between collectivism at the individual level and adherence to public health recommendations to combat COVID-19 during the pre-vaccination stage of the pandemic, and examines different characteristics of collectivism (i.e., concern for community, trust in institutions, perceived social norms) as potential psychological mechanisms that could explain greater compliance. A study with a cross-section of American participants (N = 530) examined the relationship between collectivism and opting-in to digital contact tracing (DCT) and wearing face coverings in the general population. More collectivistic individuals were more likely to comply with public health interventions than less collectivistic individuals. While collectivism was positively associated with the three potential psychological mechanisms, only perceived social norms about the proportion of people performing the public health interventions explained the relationship between collectivism and compliance with both public health interventions. This research identifies specific pathways by which collectivism can lead to compliance with community-benefiting public health behaviors to combat contagious diseases and highlights the role of cultural orientation in shaping individuals’ decisions that involve a tension between individual cost and community benefit.
Ice-nucleating agents in sea spray aerosol identified and quantified with a holistic multimodal freezing model

Sea spray aerosol (SSA) is a widely recognized important source of ice-nucleating particles (INPs) in the atmosphere. However, composition-specific identification, nucleation processes, and ice nucleation rates of SSA-INPs have not been well constrained. Microspectroscopic characterization of ambient and laboratory-generated SSA confirms that water-borne exudates from planktonic microorganisms composed of a mixture of proteinaceous and polysaccharidic compounds act as ice-nucleating agents (INAs). These data and data from previously published mesocosm and wave channel studies are subsequently used to further develop the stochastic freezing model (SFM) producing ice nucleation rate coefficients for SSA-INPs. The SFM simultaneously predicts immersion freezing and deposition and homogeneous ice nucleation by SSA particles under tropospheric conditions. Predicted INP concentrations agree with ambient and laboratory measurements. In addition, this holistic freezing model is independent of the source and exact composition of the SSA particles, making it well suited for implementation in cloud and climate models.
Reconfiguring band-edge states and charge distribution of organic semiconductor–incorporated 2D perovskites via pressure gating

Two-dimensional (2D) semiconductor heterostructures are key building blocks for many electronic and optoelectronic devices. Reconfiguring the band-edge states and modulating their interplay with charge carriers at the interface in a continuous manner have long been sought yet are challenging. Here, using organic semiconductor–incorporated 2D halide perovskites as the model system, we realize the manipulation of band-edge states and charge distribution via mechanical—rather than chemical or thermal—regulation. Compression induces band-alignment switching and charge redistribution due to the different pressure responses of organic and inorganic building blocks, giving controllable emission properties of 2D perovskites. We propose and demonstrate a “pressure gating” strategy that enables the control of multiple emission states within a single material. We also reveal that band-alignment transition at the organic-inorganic interface is intrinsically not well resolved at room temperature owing to the thermally activated transfer and shuffling of band-edge carriers. This work provides important fundamental insights into the energetics and carrier dynamics of hybrid semiconductor heterostructures.