Miracle-dz/UniFAR-FTUs huggingface dataset:
Associations of Snoring, Daytime Napping and Night Sleep Duration With Hyperuricemia in Rural Chinese Adults: the Henan Rural Cohort Study

Background. Evidence on the association of snoring, daytime napping or sleep duration with hyperuricemia (HUA) was limited, especially in the resources-poor areas. This study aimed to investigate the independent and joint effect of snoring frequency, daytime napping and sleep duration with prevalence of HUA in rural Chinese adults. Methods. 29,643 participants aged 18-79 years were included from baseline survey of the Henan Rural Cohort Study. Sleep variables were assessed using the Pittsburgh Sleep Quality Index (PSQI). Multivariate logistic regression and linear regression models with HUA and serum uric acid level as dependent variables were conducted, respectively. Results. Of the 29,643 included adults, 3498 suffered from HUA. Compared to never snoring, the adjusted odds ratio (OR) and 95% confidence interval (CI) of HUA for rare snoring, occasional snoring and habitual snoring were 1.35 (1.17, 1.56), 1.30 (1.14, 1.47) and 1.59 (1.47, 1.73), respectively. Compared with no napping, participants who had daytime napping of 61-90 and >91 min were associated with 29% and 30% increase in prevalence of HUA, respectively. But in night sleep duration groups, no significant associations were observed (all P>0.05). The positive associations between snoring and HUA were attenuated in older, female adults and those with chronic disease conditions. The joint of habitual snoring and longer daytime napping (≥61min) increased 63% prevalence on HUA. Conclusion. Snoring or daytime napping may independently increase the prevalence of HUA and serum uric acid (SUA) level. Moreover, habitual snoring and longer daytime napping might be jointly associated with a higher prevalence of HUA.Clinical Trial Registration The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). http://www.chictr. org.cn/showproj.aspx? proj=11375
NOMA Enabled UAV Data Collection with Double Energy Limitations

This paper investigates unmanned aerial vehicle (UAV) data collection systems with different multiple access schemes, where a rotary-wing UAV is dispatched to collect data from multiple ground nodes (GNs). Our goal is to maximize the minimum UAV data collection throughput from GNs for both orthogonal multiple access (OMA) and non-orthogonal multiple access (NOMA) transmission, subject to the energy budgets at both the UAV and GNs, namely \emph{double energy limitations}. 1) For OMA, we propose an efficient algorithm by invoking alternating optimization (AO) method, where each subproblem is alternately solved by applying successive convex approximation (SCA) technique. 2) For NOMA, we first handle subproblems with fixed decoding order using SCA technique. Then, we develop a penalty-based algorithm to solve the decoding order design subproblem. Numerical results show that: i) The proposed algorithms are capable of improving the max-min throughput performance compared with other benchmark schemes; ii) NOMA yields a higher performance gain than OMA when GNs have sufficient energy.
Method Development for the Assignment of NMR Peaks and the Determination of Quaternary Protein Structure using Reductive Methylation

xix CHAPTER 1 INTRODUCTION TO THE MODIFICATION OF PROTEINS FOR NMR STRUCTURAL STUDIES . 1 1.1. The Role of Proteins in Biological Systems . 1 1.2. Protein Structure . 2 1.2. 1. Amino Acids: The Building Blocks . 2 1.2. 2. Levels of Protein Structure . 4 1.2. 3. The Importance of Protein Structural Studies . 7 1.3. Protein Synthesis . 8 1.4. Protein Modifications . 9 1.4. 1. Post-Translational Modifications (PTMs) . 9 1.4. 2. Side Chain Specific Modifications . 10 1.5. Recombinant Protein Expression . 11 1.6. Chemical Side Chain Modification of Proteins . 12 1.6. 1. Lysine Specific Modifications . 13 1.6. 2. Reductive Methylation . 14 1.7. Reductive Methylation as a Structural Probe . 17 1.7. 1. Reductive Methylation as a Structural Probe for NMR and Efforts Towards the Assignment of the Resulting Dimethylamine Peaks . 18 1.8. Dissertation Scope . 24 1.9. References . 25 CHAPTER 2 – ADDRESSING DEGENERATE LABELING BY REDUCTIVE METHYLATION WITH THE USE OF SOLID PHASE MEDIA FOR THE ASSIGNMENT OF DIMETHYLAMINE NMR PEAKS . 35 2.
Comparison of Depression Severity and Sexual Satisfaction Between Fertile and Infertile Women in Iran: A Population Based Case-Control Study

Background: Depression and sexual dissatisfaction are among the most common psychological factors caused by infertility. Infertility is an important topic in Iranian culture and many studies have already targeted them. The aim of this study was to compare the severity of both depression and sexual dissatisfaction between fertile and infertile groups of women in Iran.Methods: A number of 180 infertile and 540 fertile women participated in this case-control study. The cases were selected through a combination of multistage stratified and cluster sampling method. For each infertile woman, three fertile women were randomly selected. Data gathering instrument consisted of demographic variables, Depression Inventory Scale, Second Edition, and the Linda Berg Sexual Satisfaction Questionnaire. The multivariate marginal model and SPSS 21 software were used for data analyses with a significance level of 0.05. Results: After adjusting for the effect of confounding variables, the marginal model showed the odds of depression increased by approximately 21.305 times among cases compared to control subjects (OR = 21.305, 95% CI for OR:14.75-32.021, P < 0.001). This model also found that by moderating the effect of confounding variables, infertility increased the odds of low sexual satisfaction by approximately 15.560 times (OR = 15.560, 95% CI for OR = 5.089–47.571, p < 0.001). Chi-square test (Monte Carlo Simulation) showed a significant relationship between infertility treatment and severity of depression in infertile group of women (P = 0.001). Severe cases of depression were mostly seen among women who received IVF treatment.Conclusion: The overall severity of depression and sexual dissatisfaction were higher in infertile group than that of fertile one. Also, most cases of severe depression were seen in IVF clinics, which may boost their depression. The results of this study may help reveal the psychological and social aspects of infertility in, Iran.
Spatial Differences of Overweight and Obesity among Schoolchildren in Shandong Province, China

Background: Overweight and obesity are becoming a big issue in Shandong province. Based on the big data of children and adolescents in Shandong province, we try to explore the spatial differences and explain the causes of this phenomenon, so as to provide suggestions and data support for solving related problems in similar areas. Methods: The sample came from Shandong province's physical examination data in 2017. A total of 10.27 million schoolchildren aged 6-18 years were included. ArcGIS software (hot spot analysis) was used to explore the spatial differences, and regional influencing factors were analyzed by multinomial logistic regression.Results: The prevalence of overweight and obesity among schoolchildren aged 6-18 years were 17.93% and 6.79%, respectively. Moreover, boys/girls, urban/rural areas both showed that the former rate was higher than the latter, and the 9-11 age group was confirmed to have the highest prevalence. Regional distribution illustrated that, in Shandong province, the areas with high prevalence of overweight and obesity were mainly concentrated in the central, northern and eastern parts, and the hot spot clusters were located in Yantai and Weihai, while the low-value areas were aggregated in the western (boys) and southern (girls) regions. Further exploration revealed that total retail sales of consumer goods (CGTRS) and per capita disposable income (PCDI) were confirmed as risk factors for regional obesity level.Conclusions: The spatial difference of overweight and obesity is statistically significant between the eastern region (high value cluster) and the western region (low value cluster), and it is influenced by some regional factors, suggesting that for a few regions, relevant department should pay more attention to this phenomenon. More education on this problem should be done to make people know more about health, and more researches should be done to see what intervention could solve this problem.
Analisis pengaruh inflasi, kurs dan produksi terhadap ekspor tembakau di Indonesia

This study was conducted to see the contribution of tobacco exports to the total exports of the Indonesian plantation sub-sector for the period 2000 – 2018 and to see the effect of inflation, exchange rates, and growth of Indonesian tobacco production on Indonesian tobacco exports for the period 2000 – 2018. The type of research used to analyze the data in this study is descriptive quantitative. This study uses multiple linear regression analysis based on Ordinary Least Square (OLS). Based on the results of the regression calculation of the development of each variable, namely inflation, exchange rates and production growth, it is obtained by these three variables that growth fluctuates throughout the research period which can be caused by economic conditions or can be caused by the influence between variables. Keywords: Export volume, Inflation, Exchange rates, Production growth
Poly(I:c)-priming Improved the Therapeutic Efficacy of Mesenchymal Stromal Cells on Experimental Colitis by Promoting the Expression of Indoleamine 2,3-dioxygenase

Background:Inflammatory bowel disease is a chronic and excessive inflammation of the colon and small intestine. We previously reported that priming of mesenchymal stromal cells (MSC) with poly(I:C) induced them to express indoleamine 2,3-dioxygenase (IDO). We tried to find out whether the poly(I:C)-primed MSCs have better therapeutic efficacy on the experimental colitis in the IDO1-dependent manner. Methods:To compare the therapeutic effects between the naïve MSCs and primed MSCs on murine colitis, mice (C57BL6) were administered with 2.5% dextran sodium sulfatein drinking water for 5 days and injected with MSCs intraperitoneally on days 1 and 3 following DSS ingestion. The disease activity index score and body weight loss were significantly improved after injection of the primed MSCs. Results:Mice receiving the poly(I:C)-primed MSCs showed a reduced disease activity index and less weight loss. Colon tissue from the same mice presented attenuated pathological damage, increased Paneth cells, increased IDO1-expressing cells, and better proliferation of enterocytes. The primed MSC treatment upregulated the mRNA expression of intestinal stem cell markers (Lgr5, Olfm4, and Bmi1), enterocyte differentiation markers (Muc2, Alpi, Chga, and occludin), and regulatory T (Treg) cells (Foxp3). The same treatment decreased inflammatory cell infiltration to lymphoid organs and the level of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, and MCP-1) in colon tissue. Notably, in vivo pharmacologic inhibition of the IDO1 activity blocked the Foxp3 up-regulation in colon tissue and diminished the protective effects of the primed MSC. Conclusions: The priming of MSCs with poly(I:C) is a promising new strategy to improve the therapeutic efficacy of MSC and is worth further research.
Educational Intervention for Increasing Teachers’ ADHD Knowledge, Attitude, and Behavior

Background: this study evaluated the effect of an educational intervention for increasing elementary school teachers’ ADHD knowledge, attitudes, and behavior.Method: Teachers from 12 schools who had at least one students with a definitive diagnosis of ADHD participated in the study and were allocated into either an intervention (n=31) or control group (n=27). Teachers’ ADHD knowledge, Attitude, and Behavior were assessed before and after intervention. Six-session participatory intervention were provided only for the intervention group.Results: Two mounts after the intervention, the intervention group scored significantly higher on all three outcomes (P≤0.001). Conclusion: The educational intervention significantly improved teachers’, knowledge, attitudes as well as their behaviors and strategies to manage children with ADHD. It is recommended that this program will incorporate into in-service training courses for primary school teachers as a means of facilitating teaching and managing children with ADHD in class. Trial registration: The study was approved by the by the Research Deputy of Isfahan University of Medical Sciences. In addition, The Ethical Committee of Isfahan University of Medical Sciences approved the study proposal. (ID code: IR.MUI.RESEARCH.REC.1398.297). The required permission from Education Department of Isfahan City was attained. Participation in the study was voluntary. Before taking part in the study, selected teachers provided written consent also study goals were described to them.
“It’s A Steeper Hill for Women to Climb!”: An Intersectional Gender Analysis of Familial and Socio-Cultural Drivers of Inequitable Scientific Career Progression of Researchers in the Context of the DELTAS Africa Initiative

Background: This study sought to illuminate familial and socio-cultural drivers that contribute to intersectional gender inequities in scientific career progression in Sub-saharan Africa (SSA) by drawing on lived experiences of women and men researchers. The findings are drawn from a wider research study that was aimed at gaining an in-depth understanding of the barriers and enablers of gender equitable scientific career progression for researchers in SSA. This was nested within the context of ‘Developing Excellence in Leadership, Training and Science in Africa’ (DELTAS Africa) – a health-based scientific research capacity strengthening initiative. Methods: The study adopted an exploratory qualitative cross-sectional study design. In-depth interviews were conducted with fifty-eight (32 Female and 26 Male) trainees/research fellows at various career stages, supported and/or affiliated to three purposively selected African Research Consortia. The interviews were conducted between May and December 2018 in English. The data was analysed inductively based on emergent themes.Results: Four themes were identified. First: characterisation of the normative career pathway and progression requirements. Second: social power relations of gender within the family and wider society. Third: researchers’ experiences of navigating between the ‘two different lives’, and the resultant implications for their career progression and personal well-being. Fourth, potential strategies utilised by women for navigating the ‘two different lives’ and their impacts. Conclusions: This study offers important policy and practice measures and approaches for fostering equitable scientific research career progression for women and men within research capacity strengthening initiatives in SSA. These includes the need for: reforms in institutional human resources policies and systems; a more fundamental re-think of the normative scientific career structure to create equitable opportunities, improving diversity and well-being of both female and male researchers; additional support and potential adjustments to expectations for language minorities in science; and embracing gender transformative approaches in science.
PENGARUH SERVICESCAPE TERHADAP KEPUASAN PENGUNJUNG BULELENG FESTIVAL DI KABUPATEN BULELENG

Sektor pariwisata merupakan sektor andalan yang memberikan kontribusi atau sumbangan secara finansial yang cukup besar dalam aktivitas bisnis event festival di Provinsi Bali. Salah satu Kabupaten yang sudah beberapa kali melaksanakan kegiatan festival dan memiliki daya tarik alam dan budaya yang menarik adalah Kabupaten Buleleng. Pemerintah Kabupaten Buleleng menyelenggarakan event festival yaitu salah satunya Buleleng Festival. Diadakannya Buleleng Festival merupakan suatu representasi akan mengangkat kembali budaya lokal yang dapat membangkitkan jati diri Kabupaten Buleleng. Budaya lokal Kabupaten Buleleng diaplikasikan dalam suatu bentuk kegiatan event festival. Salah satu event festival yang menjadi menarik untuk menjadikan pilihan pengunjung adalah Buleleng festival. Buleleng festival merupakan event festival yang mengutamakan desain dan konsep event yang menarik. Semakin banyaknya event festival yang dilaksanakannya di Kabupaten Buleleng, menuntut para perencana dan pengelola event akan memiliki imajinasi yang kreatif, inovatif dalam menampilkan konsep event dengan memperhatikan servicescape dan kegiatan yang beranekaragam untuk meningkatkan daya tarik dan minat pengunjung. Adapun tujuan penelitian adalah untuk mengkaji bagaimana pengaruh servicescape terhadap kepuasan pengunjung Buleleng festival. Jumlah sampel yang digunakan adalah sebanyak 90 responden dengan teknik purposive sampling. Pengolahan data yang digunakan dengan analisis regresi linier berganda pada program SPSS versi 20. Hasil penelitian menunjukkan terdapat hubungan positif secara parsial pada dimensi suasana yaitu 0,570, dimensi disain yaitu 0,477 dan dimensi sosial yaitu 0,617 terhadap kepuasan pengunjung. Dan secara simultan dari dimensi suasana, dimensi disain dan dimensi sosial yang telah diimplementasikan dalam event Buleleng festival terhadap kepuasan pengunjung memiliki hubungan yang kuat yaitu sebesar 0,728.
Pengaruh Pengalaman Kerja, Independensi, Integritas, Kompetensi Dan Etika Auditor Kualitas Audit

The purpose of this study is to assess and evaluate the influence of work experience, autonomy, honesty, competence and audit ethics on the audit quality of the public accounting firm in Makassar city. This method of analysis used in the study is quantitative with primary data sources, which are data collected by administering questionnaires directly without intermediaries. Multiple linear regression analysis was used using the t-test to prove and evaluate this. There were 48 respondents to the number of samples in this report. The validity test, reliability test, normality test, multicollinearity test, heteroscedasticity test, multiple linear regression test, coefficient determination test, t-test, and f test were used for data analysis. The conclusion of this analysis is that there is a positive and important influence of work experience on the consistency of audits. Freedom has a positive and powerful influence on the consistency of audits. Integrity has a positive and meaningful influence on the consistency of audits. Competence has a positive and important effect on the quality of the audit, and Auditor Ethics has a positive and important impact on the quality of the audit.
Determination of chlortetracycline residues in swine tissues using high performance liquid chromatography

A study was undertaken to detect residues of Chlortetracycline in swine tissues using High Performance Liquid Chromatography (HPLC). About 300 nos. of representative swine tissue samples were collected from pork markets and roadside meat stalls located in and around Guwahati city of Assam. The samples after collection were preserved at -20 °C and then screened by High Performance Liquid Chromatography with UV-Vis Detector. Chlortetracycline residues were extracted with EDTAMcIIvaine buffer. Solid phase extraction clean up was done with SPE C18 cartridge. Recovery ranged from 94-98 %. About 8 nos. of the screened samples were detected to be positive for trace residues of chlortetracycline below the Maximum Residue Limit (MRL). It may be concluded that the screened samples were detected for residues well below the MRL.
Role of TROP2, Cyclin D1 and FOXP3 in Bladder Carcinoma in Egyptian Patients: An Immunohistochemical Study

BackgroundIn Egypt, Urinary bladder carcinoma is a common malignancy accounting for 14.3% of total malignancies in both sexes with 3:1 male to female ratio. It comprises 88.3% of the total urinary system tumors. To reduce bladder cancer morbidity and mortality there is an urgent need to identify novel tumor marker which are specific enough for prognosis and can serve as effective anticancer targets . Therefore the purpose of this study is to evaluate the role of TROP2, CYCLIN D1, FOXP3 and their relationship with the established clinico-pathological parameters and overall survival of bladder cancer in Egyptian patientsMethodsUsing the standard immunohistochemical technique, TROP2, CYCLIN D1 and FOXP3 expression in 80 primary bladder carcinomas and 20 specimens as non neoplastic group were assessed. The bladder carcinoma cases included 50 cases with muscle invasive bladder cancer and 30 cases with non-muscle invasive bladder cancer ResultsOverexpression of both TROP2 and FOXP3 implied poor prognostic impact as significantly associated with muscle invasive bladder cancer, high grade, advanced stage, lymph node involvement and high mitotic count. Cyclin D1 displayed an inverse relation with both TROP2 and FOXP3 reflecting a favorable prognostic impact. Tumoral FOXP3 expression is directly correlated with peritumoral FOXP3+ lymphocytes expression. TROP2, CYCLIN D1, FOXP3 expression didn’t affect the overall survival of the studied sample.ConclusionsThe inverse relation between Cyclin D1 and TROP2 proposes consumption of Cyclin D1 by TROP2 as a ligand in the urinary bladder carcinogenesis. Strong diffuse overexpression of both TROP2, and FOXP3 could be promising potential biomarkers for identifying patients with poor prognostic factors in bladder cancer serving as potential targets for cancer therapy.
Contribution of multivariate analysis to the correlation of some properties of kaolin with its mineralogical and chemical composition

AB S T R A C T : According to multivariate analysis, the following were established (a) kaolinite crystallinity index (KCI) values determined by XRD are highly correlated to one another and seemingly influenced by kaolin impurities; (b) kaolin minerals are concentrated mainly in the fractions <4 mm; (c) the kaolin surface area as determined by the BET (nitrogen adsorption) method is more markedly affected by kaolin impurities than by kaolin minerals themselves; (d) BET surfaces increase when kaolinite crystallinity decreases; (e) brightness is inversely correlated with kaolin impurities; (f) the more ordered the kaolinite and the greater the proportion in the <4 mm fraction of the kaolin, the greater the brightness; and (g) KCI values are particle size-distribution dependent for sedimentary-residual kaolins. The correlations obtained were better when kaolins were selected according to their origin because the kaolin minerals and their impurities, particle size-distribution and texture were more alike. The industrial properties of kaolin can not be predicted from other basic properties such as mineralogy, KCI, etc., because they are intricately related to one another.
Dynamic Relationship between Stock Prices and Exchange Rates: Evidence from Chinese Stock Markets

This paper empirically examines the short-run and long-run causal relationship between stock market prices and exchange rates in Chinese stock markets using monthly data from January 2002 to December 2012 retrieved from the National Bureau of Statistics of the People’s Republic of China. Unit root, cointegration tests, vector error correction estimates, block exogeneity Wald tests, impulse responses, variance decomposition techniques and structural break tests are employed. This study found 1) long-run causality from exchange rates to stock prices in Chinese stock markets and 2) short-run causality from Japanese yen and Korean won exchange rates to stock prices in the Shanghai Stock Exchange strongly prevails while in the Shenzhen Stock Exchange weakly prevails . The impact of the global financial crisis from 2007 to 2009 on Chinese stock markets was insignificant.