Miracle-dz/UniFAR-FTUs huggingface dataset:
System Availability Study Results in the Example of Radio Communication System in the Underground Mine

The availability rating of any system is the probability that it will be able to operate for a given time in other words, to restore the system in the case of a system failure, or during the failure it is a measure of the availability index of resource system. We aimed to complete the study for the reasons as below. The rating and upgrading of underground mine radio communication system availability is to ensure operation reliability of the underground mine and to establish reliable radio communication system for miner’s safety during failure. Therefore, our study is contributed to reveal system availability rating of single resource (with two parallel connections) system and two resources (with three parallel connections) system. The study is related to not only practical contribution but also reliability engineering theory. To achieve this result, we have used Exponential, Weibull, and Poisson distributions. The readiness rating of single resource (with two parallel connections) and two resources (with three parallel connections) systems were calculated using Matlab software and the simulation results were introduced. This result confirms that any system has a resource system, which increases its readiness rating. The study was in examples of single resource radio communication system on the two shafts of the underground mine and two resource radio communication system for three shafts. During the initial system reliability enhancement study, the readiness of the dual resource system was assessed. The rating shows a 99 percent result, which is very meaningless for systems with more than two n-resources and we have revealed that it can show more than 100 percent result. In the process of the study on system reliability improvement the rating availability of system which has two resources was 99 % result. It is very meaningless for systems with more than two n-resources or more than 100% result.
Replication studies in the clinical decision support literature-frequency, fidelity, and impact

OBJECTIVE To assess the frequency, fidelity, and impact of replication studies in the clinical decision support system (CDSS) literature. MATERIALS AND METHODS A PRISMA-compliant review identified CDSS replications across 28 health and biomedical informatics journals. Included articles were assessed for fidelity to the original study using 5 categories: Identical, Substitutable, In-class, Augmented, and Out-of-class; and 7 IMPISCO domains: Investigators (I), Method (M), Population (P), Intervention (I), Setting (S), Comparator (C), and Outcome (O). A fidelity score and heat map were generated using the ratings. RESULTS From 4063 publications matching search criteria for CDSS research, only 12/4063 (0.3%) were ultimately identified as replications. Six articles replicated but could not reproduce the results of the Han et al (2005) CPOE study showing mortality increase and, over time, changed from truth testing to generalizing this result. Other replications successfully tested variants of CDSS technology (2/12) or validated measurement instruments (4/12). DISCUSSION A replication rate of 3 in a thousand studies is low even by the low rates in other disciplines. Several new reporting methods were developed for this study, including the IMPISCO framework, fidelity scores, and fidelity heat maps. A reporting structure for clearly identifying replication research is also proposed. CONCLUSION There is an urgent need to better characterize which core CDSS principles require replication, identify past replication data, and conduct missing replication studies. Attention to replication should improve the efficiency and effectiveness of CDSS research and avoiding potentially harmful trial and error technology deployment.
Theory of Planned Behavior Analysis of Social Distancing During the COVID-19 Pandemic: Focusing on the Intention–Behavior Gap

Abstract Background As COVID-19 continues to spread globally, it is important to understand psychological factors that may influence compliance with social distancing. Purpose The present study examined whether Theory of Planned Behavior (TPB) constructs were associated with social distancing, with a focus on exploring moderators of the intention–behavior relationship. Methods Using a longitudinal design, U.S. adults (N = 507) self-reported TPB constructs and social distancing behavior at baseline and 3 months later. Participants were from 48 U.S. States and the District of Columbia and were on average 50.39 years old (SD = 15.32, range = 18–80). The majority were Non-Hispanic White (71.6%), had a bachelor’s degree or higher (55.3%), and resided in suburban areas (55.8%). Results While positive attitudes toward social distancing increased over time (p = .002), subjective norms weakened (p < .001) and perceived behavioral control (PBC) remained stable (p = .22). Interestingly, despite an increase in intentions from baseline to follow-up (p < .001), there was a significant decrease in social distancing behavior over time (p < .001). Consistent with the TPB, baseline attitudes (p < .001), subjective norms (p < .001), and PBC (p < .001) for social distancing were all associated with baseline intentions to social distance. In turn, baseline intentions were significantly associated with social distancing behavior at follow-up (p < .001). Younger adults (p < .001) and non-White participants (p = .002) displayed a greater intention–behavior gap relative to older and White participants. In contrast, participants with more stable intentions over time displayed a stronger intention–behavior relationship (p < .001). Conclusions Targeting individuals’ attitudes, norms, and PBC may effectively promote protective behaviors intended to mitigate the spread of COVID-19 and similar viral outbreaks. Future research should examine effective strategies for translating social distancing intentions into actions.
Uncertainty in Faith, Fear of Death? Transitions in Religious Doubt and Death Anxiety in Later Life

While religiosity is usually associated with lower death anxiety, holding doubts about one’s faith are associated with higher death anxiety. Using longitudinal data from the Religion, Aging, and Health Study (2001–2004), this study examines within-individual changes in religious doubt and death anxiety. Results from lagged dependent variable models suggest that compared to older adults who did not experience any doubt about their faith, those holding consistently high doubt or increasing or decreasing doubt reported greater death anxiety. Lingering religious doubt was associated with higher death anxiety among weekly religious attenders. Taken together, our findings suggest that being more assured in one’s faith and spiritual understanding may lead to a more peaceful experience when confronting thoughts about one’s own mortality, especially for older adults holding a stronger religious identity. We situate our findings within the literature on the “dark side” of religion and well-being in later life.
A Study on stability of iodized salt

Objective To observe the stability of iodized salt and its affective factors during storage.Methods Total 572 salt samples were collected from whole country and stored locally in kitchens and factory storehouses with different packages for one year period, and the room temperature and humidity were recorded regularly. Every three months samples from each package were sent to a laboratory for measuring iodine content.Results ①There was no difference in mean iodine content among 5 measurements (F=1.792,P=0.128), which indicated no iodine loss over one year. ②However, some variations in iodine content were found in all samples when test values were compared with their baseline value measured from the first day sample. But the probability of the bias to the baseline value occurred in positive and negative was almost equal, which indicated again no iodine loss. ③After multiple factorial analysis we found that the raw salt, crushed/washed salt, sun evaporated salt and sack packaged salt were easier to produce larger variation of iodine content, and temperature and humidity were also two importantly affective factors.Conclusions Iodized salt (KIO 3) is quite stable with no iodine loss during one year storage. The salt quality, storage conditions and homogeneity of iodization process or sample collection are all important factors to produce large variations in iodine content.
Replication Dynamics for Six Gram-Negative Bacterial Species during Bloodstream Infection

Bloodstream infections are a global public health problem. The goal of this work was to determine the replication characteristics of Gram-negative bacterial species in the host following bloodstream infection. ABSTRACT Bloodstream infections (BSI) are a major public health burden due to high mortality rates and the cost of treatment. The impact of BSI is further compounded by a rise in antibiotic resistance among Gram-negative species associated with these infections. Escherichia coli, Serratia marcescens, Klebsiella pneumoniae, Enterobacter hormaechei, Citrobacter freundii, and Acinetobacter baumannii are all common causes of BSI, which can be recapitulated in a murine model. The objective of this study was to characterize infection kinetics and bacterial replication rates during bacteremia for these six pathogens to gain a better understanding of bacterial physiology during infection. Temporal observations of bacterial burdens of the tested species demonstrated varied abilities to establish colonization in the spleen, liver, or kidney. K. pneumoniae and S. marcescens expanded rapidly in the liver and kidney, respectively. Other organisms, such as C. freundii and E. hormaechei, were steadily cleared from all three target organs throughout the infection. In situ replication rates measured by whole-genome sequencing of bacterial DNA recovered from murine spleens demonstrated that each species was capable of sustained replication at 24 h postinfection, and several species demonstrated <60-min generation times. The relatively short generation times observed in the spleen were in contrast to an overall decrease in bacterial burden for some species, suggesting that the rate of immune-mediated clearance exceeded replication. Furthermore, bacterial generation times measured in the murine spleen approximated those measured during growth in human serum cultures. Together, these findings provide insight into the infection kinetics of six medically important species during bacteremia. IMPORTANCE Bloodstream infections are a global public health problem. The goal of this work was to determine the replication characteristics of Gram-negative bacterial species in the host following bloodstream infection. The number of bacteria in major organs is likely determined by a balance between replication rates and the ability of the host to clear bacteria. We selected a cohort of six species from three families that represent common causative agents of bloodstream infections in humans and determined their replication rates in a murine bacteremia model. We found that the bacteria grow rapidly in the spleen, demonstrating that they can obtain the necessary nutrients for growth in this environment. However, the overall number of bacteria decreased in most cases, suggesting that killing of bacteria outpaces their growth. Through a better understanding of how bacteria replicate during bloodstream infections, we aim to gain insight into future means of combating these infections.
How can we better prepare new doctors for the tasks and challenges of ward rounds?: An observational study of junior doctors’ experiences

Abstract Purpose Ward rounds play a crucial role in the delivery of patient care in inpatient settings, but involve a complex mix of tasks, skills and challenges for junior doctors to negotiate. This study informs the development of high-quality training by identifying the activities that junior doctors perform, and those associated with stress during real-life ward rounds. Materials and methods All activities performed by FY1 doctors (n = 60) over 2 ward rounds were coded in real-time by a trained observer using the work observation method by activity timing (WOMBAT). Doctors’ heart rate was continuously recorded and non-metabolic peaks in heart rate used as a physiological indicator of stress. Results During ward rounds, FY1 doctors commonly engaged in indirect patient care, professional communication, documentation and observation. Very little time was spent on direct patient care (6%) or explicit supervision/education (0.01%). Heart rate data indicated that stress was highest during administrative tasks while interacting directly with patients while stepping out of rounds to complete personal tasks, when answering bleeps and while multi-tasking. Conclusions Training that specifically covers the activities involved, skills required, and challenges inherent in real-life ward rounds may better prepare FY doctors for this complex area of practice.
Comparison of potential psychiatric drug interactions in six drug interaction database programs: A replication study after 2 years of updates

Drug interaction database programs are a fundamental clinical tool. In 2018, we compared the category of potential drug–drug interaction (DDI) provided by six drug interaction database programs for 100 drug interaction pairs including psychiatric drugs, and found the category often differed. This study replicated the comparison in 2020 after 2 years of updates to all six drug interaction database programs.
Quantification of field incurred residues of Cyantraniliprole and IN-J9Z38 in cabbage/soil using QuEChERS/HPLC-PDA and dietary risk assessment.

Cyantraniliprole is an anthranilic diamide insecticide introduced for the effective management of diamondback moth in cabbage. Dietary risk assessment of pesticides in food is a major concern nowadays. In the present investigation, a QuEChERS-HPLC/PDA based highly efficient and reliable method, registering 89.80-100.11% recoveries of cyantraniliprole and its metabolite IN-J9Z38 from cabbage and soil with 0.43-5.77% RSD has been developed. Field experiment was conducted to study residue dissipation of cyantraniliprole in cabbage and soil. Two foliar applications of 10.26% formulation (Benevia®) @ 60 (T1 ) and 120 (T2 ) g a.i./ha (gram active ingredient/hectare) were given. Dissipation half-lives of cyantraniliprole in cabbage and soil were determined as 3.5 to 4.2 days and 3.8 to 5.3 days at T1 and 3.9 to 4.8 days and 4.1 to 4.7 days at T2 , respectively. Maximum concentrations of IN-J9Z38 at T1 and T2 were 0.819 and 1.061 mg/kg respectively on 5th day. Risk quotient (RQ) value of <1 indicates no dietary risk to the consumers. Residues in the harvested cabbage were below the tolerance level of 2.0 mg/kg established by the regulatory body in India.
Bruch Membrane Opening Minimum Rim Width in Neuromyelitis Optica

Background: Optical coherence tomography (OCT) analyzes the neurodegeneration in neuromyelitis optica (NMO) and multiple sclerosis (MS) and quantifies optical atrophy. The retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness are decreased, and this structural change is correlated with visual function of patients, including contrast vision and visual field deviation. The main objective of this study was to evaluate the Bruch membrane opening minimum rim width (BMO) of the patients with NMO. Methods: We studied the thickness of the BMO by OCT, in patients with NMO (n = 25; 34 eyes), MS (n = 50; 70 eyes), and a control group (n = 51; 100 eyes). The study evaluated the structure–function relationship with the correlation between OCT and visual function: Visual acuity, Pelli–Robson score, Sloan 2.5 and 1.25, color vision, standard automated perimetry (SAP), and frequency-doubling technology perimetry (FDT). Results: The average thickness of BMO was significantly reduced in NMO and MS with or without a history of optic neuritis (ON). Significant thinning of the average, nasal, and inferonasal BMO in the absence of ON in NMO was found compared with controls (P = 0.022, 0.006, and 0.026, respectively). BMO was strongly correlated with Pelli–Robson score (P < 0.001), Sloan 2.5 (P < 0.001), and mean deviation of SAP and FDT (P = 0.004). The sectorial study found a high correlation between the BMO and the corresponding sector of the visual field. Conclusions: The BMO thickness is decreased after ON in NMO and MS. This study showed an improved ability of BMO over RNFL and GCL to detect infraclinical impairment in patients with NMO without a history of optic neuropathy. Like the RNFL and GCL, BMO is well correlated with visual function, including contrast vision and visual field deviation.
COVID-19 in celiac disease: a multicentric retrospective cohort study.

OBJECTIVE Celiac disease (CD) is an autoimmune disorder, characterized by increased susceptibility to bacterial and viral infections. Therefore, the CD patients could be exposed to an increased risk of contracting SARS-CoV-2, a virus for which the WHO declared a pandemic status in March 2020. This study aims to investigate the incidence of SARS-CoV-2 infection in CD patients, to assess the impact of CD on the risk of contracting this virus. PATIENTS AND METHODS This retrospective multicentric cohort study evaluated 542 celiac patients, who answered a questionnaire concerning both the underlying disease (adherence to the gluten-free diet, residual symptoms) and the possible SARS-CoV-2 infection (swab outcome, presence and characteristics of symptoms and type of treatment received), referring to the period between 20th January 2020 and 27th October 2020. RESULTS Five patients (0.92%) tested positive; of these, 2 were asymptomatic and 3 developed symptoms of COVID-19. The incidence of SARS-CoV-2 infection in CD patients was not significantly different from the general population. The ratio of positive/diagnostic swabs tends to be higher in CD patients than in the general population (IR: 0.15; 0.06; p=0.06), whereas the number of subjects who performed the swab in this group is significantly lower (IR: 0.06; 0.15; p<0.001). CONCLUSIONS Although CD patients are more susceptible to infections, the incidence of SARS-CoV-2 infection in our sample was not significantly different from the general population. However, the positive/diagnostic swabs ratio seems to be higher, probably also due to the lower number of patients tested.
Lagerstroemia speciosa (L.) Pers., ethanolic leaves extract attenuates dapsone-induced liver inflammation in rats

Abstract Drug-induced liver injury is a common cause of acute liver failure. Dapsone is increasingly used in combination with rifampicin for the treatment of leprosy and also for several dermatological disorders. Clinically, abnormal liver function and focal bile duct destruction were reported after dapsone therapy. Lagerstroemia speciosa Pers. , commonly known as Banaba has been traditionally used to treat various ailments including diabetes and obesity due to its antioxidant and anti-inflammatory efficacies. This study investigated the hepatoprotective effect of ethanolic banaba leaves extract (EBLE) against dapsone-induced hepatotoxicity in rats. Dapsone (30 mg/kg, i.p.) was administered twice daily for 30 days. In separate groups, rats were post-treated orally with EBLE (250 and 500 mg/kg) and silymarin (100 mg/kg) once daily for 30 days after dapsone administration. The marker enzymes of hepatotoxicity, oxidative stress markers, inflammatory markers and histopathology of liver were done. HPTLC analysis confirmed the presence of 12.87 µg of corosolic acid per mg of EBLE. Dapsone administration-induced significant (p < 0.001) elevation of marker enzymes of hepatotoxicity in serum. This treatment also increased lipid peroxidation (p < 0.001) and pro-inflammatory markers (tumor necrosis factor-alpha, transforming growth factor-beta, and nuclear factor kappa-B) expressions (p < 0.001) and decreased antioxidants (p < 0.001) such superoxide dismutase, catalase and glutathione in the liver tissue. All these abnormalities were significantly (p < 0.001) mitigated after EBLE (500 mg/kg) and silymarin post-treatments. The results of this study suggest that silymarin and EBLE can be used for dapsone-induced hepatotoxicity.
Gallbladder cancer epidemiology, treatment and survival in Southern Finland – a population-based study

Abstract Introduction Gallbladder cancer (GBC) is a rare malignancy in Western population with poor prognosis. This study aimed to investigate the trends in GBC incidence, treatment pattern, and survival in Finland. Methods Patients diagnosed with primary GBC in a geographically defined area (Southern Finland Regional Cancer Center) during 2006–2017 were identified. Results Final cohort included 270 patients with GBC. The incidence was 1.32/100,000 persons, and it decreased 6.8 cases per million personyears during the study period. One hundred fifty-one (56%) patients were diagnosed at Stage IV. Fifty-one patients (19%) underwent curative-intent resection with 96% R0-resection rate. The median overall survival was 7.1 months and 5-year overall survival 11.6% for all patients, and 67.7 months and 56.8% after curative-intent resection, respectively. No improvement was noted over time in overall survival in patients with GBC, or in subgroups of different stages of GBC. Conclusions The incidence of GBC is slightly decreasing in Southern Finland, but survival has not improved over time.
The widowed identity: identity transformations of the silent generation and the influence of time

ABSTRACT Divorce and death of a husband are two life events that leave older women without a life partner. But they have very different impacts. In a divorce, an older woman goes through a legal and emotional process that results in an unambiguous identity as a single woman. But the death of a husband often leaves older women in an ambiguous situation where they are physically alone but still perceived – – by themselves and others – – as part of a couple. This may be especially true for older women, because their self-identities were forged in an era when a woman’s identity was subordinated to that of her husband. Additionally, while some women become widows suddenly, others experienced a prolonged dying process that gave them time to adjust to widowhood. In the latter case the older widow has more in common with her divorced counterpart, that is, she is more likely to have an unambiguous identity as a single woman.
What's new in pediatric melanoma and Spitz tumors? Pretty much everything

Pathologists sometimes have great difficulty in determining whether a mole biopsied from the skin of a child is benign or malignant. New molecular technologies have helped pathologists to identify pediatric melanomas, but there are still some atypical moles that cannot be definitively classified as benign or malignant. With further research, it is hoped that the number of these atypical tumors can be decreased and that the treatment for all children with moles and melanoma can be improved.