Miracle-dz/UniFAR-FTUs huggingface dataset:
Hematological Toxicity in Mice after High Activity Injections of 177Lu-PSMA-617

Prostate cancer (PC) is one of the most common malignancies affecting men, with poor prognosis after progression to metastatic castration-resistant prostate cancer (mCRPC). Radioligand therapy (RLT) targeting the overexpressed PSMA on PC cells, with, e.g., 177Lu-PSMA-617, has been effective in reducing tumor burden and prolonging survival in mCRPC. However, it is not a curative method with kidney and bone marrow toxicity limiting the activity given to patients. Previous preclinical models have reported transient hematotoxicity for up to 120 MBq. This activity may still be too low to investigate the effect on renal function since it corresponds to an absorbed dose below 10 Gy, whereas the kidneys in a clinical setting usually receive an absorbed dose more than double. Here we investigated the hematotoxicity and recovery after administered activities of 120, 160, and 200 MBq in a 177Lu-PSMA-617 BALB/cAnNRj mouse model. The animals had an initial drop in white blood cells (WBC) starting 4 days post injection, which recovered after 21 days. The effect on red blood cells (RBC) and platelets was detected later; 17 days post-injection levels decreased compared to the control group. The reduction was restored again 32 days post injection. No correlation between injected activity and hematotoxicity was found. Our results suggest that activities up to 200 MBq of 177Lu-PSMA-617 give transient hematotoxicity from which animals recover within a month and no radiation-related deaths. Injecting these high activities could allow animal studies with increased clinical relevance when studying renal toxicity in animal models.
Ranks of Identity Difference Transformation Semigroup

This study focuses on the ranks of identity difference transformation semigroup. The ideals of all the (sub) semigroups; identity difference full transformation semigroup (IDT_n), identity difference order preserving transformation semigroup, (IDO_n), identity difference symmetric inverse transformation semigroup( IDI_n), identity difference partial order preserving symmetric inverse transformation semigroup( IDPOI_n) and identity difference partial order preserving transformation semigroup ( IDPO_n) were investigated for rank and their combinatorial results obtained respectively.
Dynamics of PHA-Accumulating Bacterial Communities Fed with Lipid-Rich Liquid Effluents from Fish-Canning Industries

The biosynthesis of polyhydroxyalkanoates (PHAs) from industrial wastes by mixed microbial cultures (MMCs) enriched in PHA-accumulating bacteria is a promising technology to replace petroleum-based plastics. However, the populations’ dynamics in the PHA-accumulating MMCs are not well known. Therefore, the main objective of this study was to address the shifts in the size and structure of the bacterial communities in two lab-scale sequencing batch reactors (SBRs) fed with fish-canning effluents and operated under non-saline (SBR-N, 0.5 g NaCl/L) or saline (SBR-S, 10 g NaCl/L) conditions, by using a combination of quantitative PCR and Illumina sequencing of bacterial 16S rRNA genes. A double growth limitation (DGL) strategy, in which nitrogen availability was limited and uncoupled to carbon addition, strongly modulated the relative abundances of the PHA-accumulating bacteria, leading to an increase in the accumulation of PHAs, independently of the saline conditions (average 9.04 wt% and 11.69 wt%, maximum yields 22.03 wt% and 26.33% SBR-N and SBR-S, respectively). On the other hand, no correlations were found among the PHAs accumulation yields and the absolute abundances of total Bacteria, which decreased through time in the SBR-N and did not present statistical differences in the SBR-S. Acinetobacter, Calothrix, Dyella, Flavobacterium, Novosphingobium, Qipengyuania, and Tsukamurella were key PHA-accumulating genera in both SBRs under the DGL strategy, which was revealed as a successful tool to obtain a PHA-enriched MMC using fish-canning effluents.
Dual-Layered Approach of Ovine Collagen-Gelatin/Cellulose Hybrid Biomatrix Containing Graphene Oxide-Silver Nanoparticles for Cutaneous Wound Healing: Fabrication, Physicochemical, Cytotoxicity and Antibacterial Characterisation

Tissue engineering products have grown rapidly as an alternative solution available for chronic wound and burn treatment. However, some drawbacks include additional procedures and a lack of antibacterial properties that can impair wound healing, which are issues that need to be tackled effectively for better wound recovery. This study aimed to develop a functionalized dual-layered hybrid biomatrix composed of collagen sponge (bottom layer) to facilitate cell proliferation and adhesion and gelatin/cellulose hydrogel (outer layer) incorporated with graphene oxide and silver nanoparticles (GC-GO/AgNP) to prevent possible external infections post-implantation. The bilayer hybrid scaffold was crosslinked with 0.1% (w/v) genipin for 6 h followed by advanced freeze-drying technology. Various characterisation parameters were employed to investigate the microstructure, biodegradability, surface wettability, nanoparticles antibacterial activity, mechanical strength, and biocompatibility of the bilayer bioscaffold towards human skin cells. The bilayer bioscaffold exhibited favourable results for wound healing applications as it demonstrated good water uptake (1702.12 ± 161.11%), slow rate of biodegradation (0.13 ± 0.12 mg/h), and reasonable water vapour transmission rate (800.00 ± 65.85 gm−2 h−1) due to its porosity (84.83 ± 4.48%). The biomatrix was also found to possess hydrophobic properties (48.97 ± 3.68°), ideal for cell attachment and high mechanical strength. Moreover, the hybrid GO-AgNP promoted antibacterial properties via the disk diffusion method. Finally, biomatrix unravelled good cellular compatibility with human dermal fibroblasts (>90%). Therefore, the fabricated bilayer scaffold could be a potential candidate for skin wound healing application.
Assessing the integrity of executive functioning in chronic aphasia

ABSTRACT Background Executive functioning (EF) deficits can commonly co-occur with language impairments in aphasia. Despite recognizing the role of EF in language and aphasia treatment outcomes, the integrity of EF in aphasia remains to be comprehensively studied. Aims The present study aimed to comprehensively examine the integrity of EF skills in individuals with different types and severities of aphasia. Accordingly, we sought to compare the performances of persons with aphasia (PWA) and healthy controls on a broad range of verbal and nonverbal EF skills using an extensive battery of assessments. To fully understand the nature of deficits in the aphasia population, we aimed to evaluate EF performances both quantitatively and qualitatively in addition to examining group- and individual-level differences. Method Persons with aphasia (PWA) and age- and education-matched healthy controls (HC) completed a battery of verbal and nonverbal EF assessments. Between-group comparisons were carried out using quantitative and qualitative EF task scores. Additionally, we conducted individual-level analyses to examine performances within the aphasia group. The influence of aphasia severity and type on EF task performances were also evaluated. Results PWA differed significantly from HC on most EF measures. Individual-level analyses revealed marked variability in performances within the aphasia group indicating that most but not all PWA demonstrated EF deficits. PWA performed significantly more poorly than HC on both verbal and nonverbal measures with greater difficulty on verbal EF tasks. No consistent relationship was found between aphasia variables and EF task performances. Conclusion Our findings indicate that many PWA demonstrate domain-general EF deficits that are not necessarily related to the degree of their language impairments. The present study emphasizes the importance of evaluating EF more routinely in clinical practice to improve rehabilitation success for PWA.
Synbiotic Supplements in the Prevention of Obesity and Obesity-Related Diseases

Obesity and being overweight have reached incredible proportions worldwide and are one of the most common human health problems. The causes of obesity are multifactorial, including a complex interplay among genes, metabolism, diet, physical activity, and the environment. The intestinal microbiota has the ability to affect the host physiology for both benefit and damage, either directly or through microbial metabolites. The aim of this review is to discuss the mechanisms by which the intestinal microbiota could act as a key modifier of obesity and related metabolic abnormalities. The synbiotic components provide an optimal target for modulation of the intestinal microbiota and help reshape the metabolic profile in obese people. The development of novel functional foods containing synbiotic ingredients may present a support in the prevention of obesity as one of the risk factors for chronic diseases. Knowledge of the synbiotic mechanisms of action and the use of new functional foods supplemented with probiotics and prebiotics will facilitate the clinical application and development of individual health care strategies.
Analysis and optimisation of the cutting parameters based on machinability factors in turning AISI 4140 steel

ABSTRACT AISI 4140 alloy steel has high abrasion resistance, toughness, torsional, and fatigue strength. Different types of this alloy with different hardness are used to manufacture gears, crankshafts, collars, jigs, and milling spindles. In this study, turning tests were carried out on AISI 4140 steel using coated carbide inserts considering Taguchi L9 orthogonal array at three different cutting speeds, feed rates, and cutting depths. The output parameters were selected as cutting forces, surface roughness, current and sound intensity. According to the ANOVA results, feed rate was the most effective parameter on the cutting force and surface roughness. As the feed rate increases, the cutting force and surface roughness value enhance. The feed rate was also the most important factor affecting the current with 81.61% contribution, followed by cutting depth with 12.67% contribution. The cutting depth with 66.95% contribution has the highest impact on the sound intensity. It was followed by a feed rate with 26.07% contribution. According to the optimisation results, the experimental and the estimated values ⁣⁣were significantly close to each other.
Salmonella and Escherichia coli contamination in wild catfish and rivers at northern part of Bangladesh

A variety of fishes consumed regularly are prone to pathogenic spoilage especially by different microbes. It is important to find out microbiological quality of fish that we consume regularly to protect the public health. Current research was conducted to assess the incidence of Salmonella and Escherichia coli (E. coli) contamination in three selected catfish species namely, Ayer (Sperata seenghala), Pabda (Ompok pabda) and Magur (Clarias batrachus) of five rivers (Dhepa, Atrai, Punorvoba, Kakra, and Ghorveshori) of Dinajpur district. The study showed that Salmonella and E. coli positive isolates were 33.33% and 55.55% in Punorvoba river, 31.03% and 50.00% in Atrai river, 30.19% and 56.60% in Dhepa river, 29.63% and 59.26% in Ghorveshori river and 27.08% and 56.25% in Kakra river, respectively. Highest percentage of Salmonella and E. coli were found in Ompok pabda (39.40%) and in Clarias batrachus (63.84%), respectively. Lowest percentage of Salmonella and E. coli were found in Sperata seenghala (26.50% and 41.07%), respectively. The percentage of E. coli was greater than Salmonella for each of the experimental samples that are very alarming for consumption of wild catfish. At the same time, the microbial quality of water of Dhepa, Atrai, Punorvoba, Kakra, and Ghorveshori rivers are not satisfactory regarding fish consumption and public health. Asian J. Med. Biol. Res. 2022, 8 (1), 9-15
Effectiveness of three different local routes of dexamethasone administration on postoperative sequelae following mandibular third molar surgery. A prospective randomised single-blind clinical study

Egypt. ABSTRACT Objective: The aim of this study was to provide evidence for comparing the effectiveness of three different routes of local administration of Dexamethasone on the postoperative pain, edema and trismus following surgical removal of impacted mandibular third molar. Material and Methods: Forty-five patients underwent surgical removal of impacted lower third molars and were randomly allocated postoperatively into 3 groups: 8 mg of dexamethasone injected into the submucosa of the vestibule near the surgical site (group I), 8 mg of dexamethasone injected into the pterygomandibular space (group II) and 10 mg of dexamethasone powder applied to the extraction site, after bleeding control (group III). Facial swelling and maximal interincisal opening were measured at preoperatively. Pain was measured by the patient response to a visual analogue scale. Pain perception, Facial edema and trismus were evaluated for one week postoperatively. Results: There was no significant difference between the three groups concerning pain after 1, 2, 5, 7 days of follow up. However, group II showed less pain at 3 and 4 days. The difference between edema measurements was not significant in the three groups at 1, 5, 7 days, though in group I and II edema subsided from day 2. As for trismus, group I and III showed statistically significant lower maximum interincisal opening measurement than group II after two days. Conclusion: Local administration of Dexamethasone through three different routes is beneficial in decreasing postoperative sequelae following third molar surgery. Pterygomandibular space injection of Dexamethasone resulted in earlier resolution of pain, and less facial edema and trismus at the second postoperative day compared to the submucosal injection and transalveolar application. However, at one week the difference in measurements of the three variables between the groups was not
Generational Cohort and Work-Life Balance Policies Preference Among University Senior Teaching Staff in Ghana: Does Gender Matter?

The study sought to examine work-life balance (WLB) policies preference among generational cohorts concerning gender. Being quantitative, a population of 714 with a sample size of 333 was selected, but 306 responded. The main independent variable was gender while the dependent variable was work-life balance policies with four dimensions: Flexible Work Arrangement; Wellness and Personal Development; Leave Arrangement and Dependent Care Assistance. The data was analysed using inferential statistics. The study results showed that except for Wellness and Personal Development, where gender difference between males and females of Generation Y existed, gender did not differ significantly from the rest of the policies. Therefore, it was recommended that there should be equal treatment of both males and females in implementing WLB policies.
Availability and Potential of Forage Production for Dairy Cattle in Ambopi Village, North Tongauna District, Konawe Regency

The availability of forage feeds greatly determines the productivity of ruminants. This study aims to determine the availability and potential of forage production for dairy cows in Ambopi village North Tongauna District, Konawe District. The method used in this study was survey carried out by purposive sampling. Data were analysed using descriptive analysis. The variables observed in this study were forages, analysis of chemical composition i.e. dry matter (DM), crude protein (CP), crude fiber (CF), extract ether (EE) and total digestible nutrient (TDN) and production and availability of grass. The results showed that there were 3 types of grass namely elephant grass ( Pennisetum purpureum ), odot grass ( Pennisetum purpureum cv Mott) and setaria grass ( Setaria sphacelata ). Average nutrient production of the three types of grass was 94.09 tons DM/ha/year, 13.19 tons CP/ha/year and 39.32 tons TDN/ha/year. It is concluded that the number of available forages has not been able to meet the needs of dairy cows because the number of dairy cows that can be accommodated is only 5 AU (Animal Unit) for 1 year in Ambopi Village.
Comparison the Results of Hysterosalpangiography in Patients with Ectopic Pregnancy Treated by Laparoscopic Salpingostomy, Laparotomy, and Treated with Methotrexate

Background: Ectopic pregnancy (EP) occurs in 1% of pregnancies, and may seriously effects on women's health and future fertility so this study aimed to compare the results of hysterosalpingography (HSG) after treatment of EP by laparoscopy, laparotomy, and methotrexate (MTX) therapy. Materials and Methods: This was a clinical trial study was done on 112 EP women with treatment indication referred to Isfahan Al-Zahran and Shahid Beheshti Hospitals from 2017 to 2018. They were divided into 33 populated groups of laparoscopic salpingostomy, laparotomy and MTX. Then patients of three groups underwent HSG 3 months after intervention. The factors such beta human chorionic gonadotropin (β–hCG) (mIU/mL), size of EP (mm), infection, hospital length of stay (LOS), and tubal patency were recorded and compared between the groups. Results: There were no significant differences between groups for age, body mass index, β–hCG, Size of EP, and hospital LOS (P > 0.05). The infection was more frequent in laparotomy group with no significant difference among three groups. The infection rates were 9%, 12%, and 6% for MTX, laparotomy, and laparoscopy arms, respectively. Between the three groups tubal patency as primary outcome had higher frequency than laparoscopy group, although, the difference was not statistically significant (P = 0.595). Conclusion: Although infection was more in laparotomy and that tubal patency was more within 3 months in laparoscopy and MTX, there were no statistically significant differences in the results of laparoscopy, laparotomy, and MTX in HSG results.
Self-Reported Cognitive Function in Persons with Nonneurological Chronic Diseases: A Systematic Review

Background Globally, one in three adults has a chronic condition. Many chronic diseases that are not neurological in nature (e.g., diabetes and heart failure) are increasingly associated with cognitive symptoms. However, the instruments used to assess cognitive symptoms in those with nonneurologic chronic illness are heterogeneous, and questions remain as to how cognitive symptoms may be related to demographic and clinical outcome variables, neurocognitive test performance, and other patient-reported outcomes. In this review, we describe associations among self-reported cognitive function, cognitive performance, and additional patient-reported outcomes as well as how cognitive symptoms are measured in nonneurologic chronic illness. Method Multiple databases (PubMed, Medline, CINAHL, PsycInfo, EMBASE, SCOPUS, the Cochrane Library, and Academic Search Complete) were searched for studies from 1990 to 2020 that provided data on self-reported cognitive symptoms in those with nonneurological chronic conditions. Initial search yielded 304 articles, of which 32 met inclusion criteria. Quality assessment was conducted using the Critical Appraisal Skills Programme. Results Thirty-two total studies were included: twenty cross-sectional, 10 longitudinal, and 2 randomized controlled trials. The tools used to assess self-reported cognitive function in the studies were heterogeneous: 28 unique tools were used. Thirty studies examined associations among self-reported cognitive function and other patient-reported outcomes. In 19 there were significant associations. Six studies showed no significant associations between neuropsychological tests and self-reported cognitive function; another 6 studies found a significant association. Conclusion Tools to assess cognitive symptoms were heterogeneous. In most studies, self-reported cognitive symptoms were not correlated with neuropsychological test results, but the majority of studies found a strong association between self-reported cognitive function and other patient-reported outcomes. Implications. Consensus on measuring cognitive symptoms would facilitate cross-study comparisons and facilitate scientific progress in those with nonneurological chronic conditions. Based on these results, there is a need to establish a standardized approach for self-reported cognitive function measurement in patients with nonneurologic chronic illness.
All Runs Are Created Equal: Labor Market Efficiency in Major League Baseball

Moneyball ( Lewis, 2003) claimed that data analytics enabled savvy operators to exploit inefficiencies in the market for baseball players. The economic analysis of Hakes and Sauer (2006) appeared to show that the publication of Moneyball represented a watershed, after which inefficiencies had been competed away. In both cases analysis focused on composite statistics such as on base percentage (OBP) and slugging percentage (SLG). This paper relies on a more structural approach, associated with the statistical analysis of Lindsey (1963) which identifies the run value of each individual event in a game. Using a dataset of every event in every game from 1996 to 2015, we show that run value of each event can be accurately calculated, as can the run value contribution of each player. We show that the compensation of free agents reliably reflects the run value contribution of each player, regardless of the source of those contributions (walks, singles, and home runs). We find this was true both before and after the publication of Moneyball, suggesting that the labor market for batters in Major League Baseball operated efficiently across our entire sample period.
Fire Fighting Tactics Under Wind Driven Fire Conditions: 7-Story Building Experiments. | NIST

In February 2008, a series of 14 experiments were conducted in a 7-story building to evaluate the ability of positive pressure ventilation fans, wind control devices and external water application with floor below nozzles to mitigate the hazards of a wind driven fire in a structure. Each of the 14 experiments started with a fire in a furnished room. The air flow for 12 of the 14 experiments was intensified by a natural or mechanical wind. Each of the tactics were evaluated individually and in conjunction with each other to assess the benefit to fire fighters, as well as occupants in the structure. The results of the experiments provide a baseline for the hazards associated with a wind driven fire and the impact of pressure, ventilation and flow paths within a structure. Wind created conditions that rapidly caused the environment in the structure to deteriorate by forcing fire gases through the apartment of origin and into the public corridor and stairwell. These conditions would be untenable for advancing fire fighters. Each of the tactics were able to reduce the thermal hazard created by the wind driven fire. Multiple tactics used in conjunction with each other were very effective at improving conditions for fire fighter operations and occupant egress. Fire departments that wish to implement the tactics used in this study will need to develop training and determine appropriate methods for deploying these tactics. Variations in the methods of deployment may be required due to differences in staffing, equipment, building stock, typical weather conditions, etc. There is uniformity however, in the physics behind the wind driven fire condition and the principles of the tactics examined. The data from this research will help provide the science to identify methods and promulgation of improved standard operating guidelines (SOG) for the fire service to enhance firefighter safety, fire ground operations, and use of equipment. The experiments were conducted by the National Institute of standards and Technology (NIST), the Fire Department of New York City (FDNY), and the Polytechnic Institute of New York University with the support of the Department of Homeland security (DHS)/Federal Emergency Management Agency (FEMA) Assistance to Firefighters Research and Development Grant Program and the United States Fire Administration.