Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of Cell-Cell Communications by Single-Cell RNA Sequencing in End Stage Renal Disease Provides New Insights into Immune Cell Heterogeneity

Objective Impaired immune system characterized by low-grade inflammation is closely associated with kidney chronic kidney disease (CKD) progression. To reveal the alterations of the function, component, and intercellular communication of immune cells during the progression of CKD. Patients and Methods We conducted a case-control study enrolling regular hemodialysis patients and healthy controls. Clinical data, serum and peripheral blood mononuclear cell (PBMC) samples were collected. Flow cytometry and single-cell RNA sequencing were performed to quantitatively analyze the immune cell subsets and T-cell subsets of PBMCs. scRNA data of GSE140023 containing mouse unilateral ureteral obstruction (UUO) models were analyzed the heterogeneity of immune cells. Results Overall reduction in peripheral blood lymphocyte subsets in patients with end-stage renal disease (ESRD) was observed. A higher ratio of Th17/Treg, Th1/Treg, and b-cell/Treg in the ESRD group was associated with a decrease in eGFR, PTH, and ferritin. Among T cell subsets identified by scRNA analysis, Th17 cells were significantly increased in the ESRD and UU0 group. TFH, Th1, and Th2 cells are located at the final stage in the developmental tree, while Treg and memory CD8+ T cells are at the beginning site. Early developmental differentiation of Th17, Th1, and Tfh cells was observed in the ESRD and UUO group. Analysis of intercellular communication between t-cell subpopulations identified two major input and output signaling pathways: the CD40 and macrophage inhibitory factor (MIF) pathways. The MIF signaling pathway primarily mediates intercellular communication among th17 effects, CD8+ t-cell, and Th17-Treg in the ESRD group, the serum level of MIF showed significant upregulation, which was closely related to Th17/Treg cells. Conclusions A global immune imbalance was closely associated with the deterioration in renal function and complication development. The MIF signaling pathway mediates Th17/Treg communication and promotes the trans-differentiation of Treg cells to Th17 cells in CKD progression.
Anthropometric Measurements in Newborns: A Comparative Study of Infants Born to Mothers With and Without Polycystic Ovary Syndrome

Objective Fetal growth can be affected by maternal PCOS and may have an impact on offspring and childhood growth. The current findings across studies are divergent and controversial. This study aims to determine whether maternal PCOS can affect the physical measurements of newborns and to establish the differences in birth weight, length, head, and chest circumference between newborns of mothers with polycystic ovarian syndrome and those of mothers without polycystic ovarian syndrome. Methods In this study, we examined the gestational age, birth weight, length, head circumference, chest circumference, and ponderal index of 75 infants born to mothers with polycystic ovary syndrome (PCOS) and compared them to those of 94 infants born to mothers without PCOS. Result Compared with the other groups, the PCOS group does not show significant differences in anthropometric indices compared to the control group. Infants born to normal and PCOS mothers birth weight were categorized as SGA (small for gestational age) if birth weight was less than the 5th percentile. LGA is large for gestational age if birth weight is greater than the 90th percentile. Other appropriate for gestational age if infant birth weight is between> 5th and < 90th percentile. Significant differences in anthropometric indices like birth weight, head circumference, and Ponderal index were observed in SGA and LGA newborns of normal and PCOS mothers. Conclusion The study findings indicate that neonates born to mothers with PCOS have higher rates of SGA and LGA newborns, and differences in anthropometric indices (birth weight, head circumference, and Ponderal index) were observed between SGA and LGA newborns of PCOS mothers.
PTCY-Based Haploidentical Donor Transplantation versus HLA-Matched Related and Unrelated Donor Transplantations in Patients with Refractory or Relapsed Lymphoma—A Matched-Pair Analysis

Simple Summary Haploidentical donor hematopoietic stem cell transplantation (Haplo-HSCT) has the potential to cure patients with refractory and relapsed (r/r) B and T cell non-Hodgkin lymphoma (NHL). In this matched-pair study, we compared intermediate and long-term outcomes between Haplo-HSCT and HLA-matched related donor (MRD) and unrelated donor (URD) transplantations in patients with r/r lymphoma using age, disease status, lymphoma classification and performance status as matching criteria. While we found comparable outcome and relapse rates among the three groups after >10 years of median follow-up, patients undergoing Haplo-HSCT exhibited lower acute and chronic graft-versus-host disease incidences. Given the rapid and nearly universal donor availability, we propose that Haplo-HSCT is an effective alternative to URD-HSCT in patients with non-remission disease. Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has demonstrated its potential as a curative option for patients with r/r lymphoma. With the introduction of post-transplant cyclophosphamide-based (PTCY) graft-versus-host disease (GvHD) prophylaxis, allo-HCT using haploidentical related donors (Haplo-HSCT) has emerged as a valuable alternative for patients without an available HLA-matched donor. In this study, we compared intermediate and long-term outcomes between Haplo-HSCT and HLA-matched related donor (MRD) and unrelated donor (URD) transplantations in 16 matched pairs using age, disease status, lymphoma classification and performance status as matching criteria. Of note, 88% of patients in each group presented with active disease at the time of conditioning. After a median follow-up of >10 years, 10-year overall and progression-free survival and non-relapse mortality incidence after Haplo-HSCT were 31%, 25% and 38%, respectively, and did not differ compared to the values observed in MRD-HSCT and URD-HSCT. A remarkable lower incidence of acute GvHD ≥ II and moderate and severe chronic GvHD was observed after Haplo-HSCT compared to MRD-HSCT (50%/50%, p = 0.03/0.03) and URD-HSCT (44%/38%, p = 0.04/0.08), resulting in slightly higher 10-year GvHD-free and relapse-free survival (25%) and chronic GvHD-free and relapse-free survival (25%) in the Haplo-HSCT group. In conclusion, Haplo-HSCT is an effective treatment in patients with non-remission NHL. Given its advantage of immediate availability, haploidentical donors should be preferably used in patients with progressive disease lacking an HLA-matched related donor.
LOOKING AT THE FUTURE OF THE MEDITERRANEAN URBAN REGIONS: DEMOGRAPHIC TRENDS AND SOCIOECONOMIC

The present study analyzed past and future trends in population and urbanization rates in the Mediterranean region. Processes such as coastalization and settlement diffusion, taken as the most relevant patterns of urban development in the region, were described using official statistics and discussed in terms of their socioeconomic and territorial implications. The link between urbanization and the growing environmental vulnerability of cities was also debated. An original planning framework oriented to a multi-scale and multi-factorial approach spanning from economic competitiveness to environmental sustainability was finally proposed.
Estimation of high-frequency wave radiation areas on the fault plane by the envelope inversion of acceleration seismograms

We have developed an inversion method to estimate high-frequency wave radiation areas on the fault plane. It is very difficult to perform a source inversion for seismic waveforms whose frequencies are higher than 1 Hz because of two problems: one is the difficulty in obtaining Green's functions that are accurate enough for such high frequencies, and the other is that involved in doing a waveform inversion for such oscillatory data. We overcame these problems by using aftershock records as empirical Green's functions, and by using the envelopes of acceleration seismograms as the inversion data instead of waveforms. Envelopes were calculated by smoothing the acceleration seismograms with a running root-mean-square time window. We applied this method to the 1993 Kushiro-Oki, Japan, earthquake (Mw= 7.6), which occurred on a horizontal fault plane inside the Pacific Plate subducting beneath the North American Plate. We adopted the MJMA 4.9 aftershock as the empirical Green's function event. We bandpass-filtered (2.0–10.0 Hz) the strong-motion acceleration seismograms at three stations and calculated the envelopes by smoothing with a 5.0 s window length. The 40 km × 60 km fault plane was divided into 4 × 6 meshes, and the acceleration radiation intensity and rupture time of each mesh were obtained by the inversion. The results are as follows. (1) High-frequency waves radiated weakly around the rupture starting point, but radiated mainly near the periphery of the fault plane. an area with particularly strong radiation intensity of high-frequency waves is seen at the edge of the fault plane about 30 km southwest of the rupture starting point; its size is about 20 km × 20 km. (2) the distribution of high-frequency radiation intensity and slip distribution are complementary to each other. That is, the radiation of high-frequency waves was strong in those areas where that of low-frequency waves was weak.
An Intra- and Inter-Dialectal Study of Korebaju Vowels

Korebaju (ISO 639-3 coe) [́ k óˀrè b à j ɨ́ ] is an endangered Tukanoan language spoken in the foothills of the Colombian Amazon. Two fieldworks carried out between 2021 and 2023 on a sample of 24 native speakers (12 females and 12 males) from two different varieties: Tama and Korebaju, located in two different villages, provide new data for improving intra-and inter-dialectal phonetic-phonological description of Korebaju. This acoustic study focuses on the vowel system of each of these two varieties and is the first part of an ongoing project on vowel nasalization and glottalization in Korebaju. The acoustic and statistical analyses indicate that there are no significant interdialectal differences between vowels. However, differences between generations of the same sex and of the same variety have been evidenced in our analyses. These results also suggest that Korebaju speakers' perception of stronger glottalization in the Tama variant refers to a morphological distinction. However, this hypothesis is still being analyzed considering the language’s tonal system, nasalization, and morphology.
Aprimorando o corretor gramatical CoGrOO

CoGrOO is an open source Brazilian Portuguese grammar checker currently used by thousands of users of a popular open source office suite. It is capable of identifying Brazilian Portuguese mistakes such as pronoun placement, noun agreement, subject-verb agreement, usage of the accent stress marker, subject-verb agreement, and other common errors of Brazilian Portuguese writing. To accomplish this, it performs a hybrid analysis; initially it annotates the text using statistical Natural Language Processing (NLP) techniques, and then a rule-based check is performed to identify possible grammar errors. The goal of this work is to reduce omissions and false alarms while improving true positives without adding new error rules. The last rigorous evaluation of the grammar checker was done in 2006 and since then there has been no detailed study on how it has been performing. This work will also contribute a detailed evaluation of low-level NLP modules and the results will be compared to state-of-the-art results. Since the low-level NLP modules are available as open source software, improvements on their performance will make them robust, free and ready-to-use alternatives for other systems.
Europe's Population in the 1990s

This study presents a contemporary picture of Europe's population, detailing birth rates, immigration, mortality, family formation and dissolution. Illustrated with numerous tables and graphs, it considers some of the causes of observed trends, such as economic pressures, the spread of new values, and the importance of family policies in creating an ageing Europe threatened by population decline.
Employee Perspectives of Leader Value Orientations, Affect, Trust, and Work Intentions

This empirical study on employee perspectives of latent leader value orientations (LVOs), employee psychological job states, and work intentions deployed an online survey to 944 employees within global organizations. Empirical analysis using structural equation modeling confirmed that employee job state positive affect fully mediated relations between LVOs and employee work intentions more so than employee job state negative affect and cognitive-based and affective-based trust in leader. LVO1 (low self-concern and high other-orientation) triggered positive employee psychological job states of greater magnitude than LVO2 (high self-concern and high other-orientation). This finding offers new insight relating to the influence of high leader other-orientation on employee psychological experiences of work considering LVO2 had been reported as ideal. LVO3 (high self-concern and low other-orientation) had the strongest differential associations with employee psychological job states implying that leaders who are perceived by employees to be driven by high self-concern, even in the presence of low other-orientation, evoke strong negative employee psychological responses. Implications for theory and practical strategies to develop leader other-orientation in organizations are presented.
Application of Guided Inquiry Learning Model to Improve Junior High School Students' Science Process Skills

The purpose of this study was to describe the improvement of students' science process skills towards the guided inquiry learning model of class VIII at SMPN 2 Semen. The method used in this research is descriptive quantitative with the type of research used quasi experiment using one treatment class, namely class VIII-E totaling 35 students. The research design used one group pretest posttest design. The data collection technique in this study used the test method. Science process skills after applying the guided inquiry learning model on the vibration and mechanical wave sub-material have increased. The percentage of completeness for post-test scores was 80%. Class VIII-E obtained an N-Gain score of 0.6 in the medium category. Thus it can be concluded that the guided inquiry learning model can improve students' science process skills.
Effects of global warming on Antarctic soil microorganisms and associated functions

23 INTRODUCTION . 24 MATERIAL AND METHODS . 26 RESULTS . 31 DISCUSSION . 40 ACKNOWLEDGEMENTS . 44 CHAPTER 3: PATTERNS OF BACTERIAL DIVERSITY ACROSS A RANGE OF ANTARCTIC TERRESTRIAL HABITATS . 45 ABSTRACT . 45 INTRODUCTION . 46 MATERIAL AND METHODS . 48 RESULTS . 51 DISCUSSION . 58 ACKNOWLEDGEMENTS . 62. 45 INTRODUCTION . 46 MATERIAL AND METHODS . 48 RESULTS . 51 DISCUSSION . 58 ACKNOWLEDGEMENTS . 62 CHAPTER 4: APPLICATION OF A 16S RRNA GENE-BASED MICROARRAY TO EXPLORE PROKARYOTIC DIVERSITY AND COMMUNITY COMPOSITION IN SOIL ENVIRONMENTS OF ANTARCTICA . 63 ABSTRACT . 63 INTRODUCTION . 64 MATERIAL AND METHODS . 66 RESULTS . 69 DISCUSSION . 77 ACKNOWLEDGEMENTS . 81. 63 INTRODUCTION . 64 MATERIAL AND METHODS . 66 RESULTS . 69 DISCUSSION . 77 ACKNOWLEDGEMENTS . 81 CHAPTER 5: FUNCTIONAL MICROARRAY ANALYSIS OF NITROGEN AND CARBON CYCLING GENES ACROSS AN ANTARCTIC LATITUDINAL TRANSECT . 83 ABSTRACT . 83 INTRODUCTION . 84 MATERIAL AND METHOD . 86 RESULTS . 92 DISCUSSION . 100 ACKNOWLEDGEMENTS . 105. 83 INTRODUCTION . 84 MATERIAL AND METHOD . 86 RESULTS . 92 DISCUSSION . 100 ACKNOWLEDGEMENTS . 105 CHAPTER 6: RESPONSES OF ANTARCTIC SOIL MICROBIAL COMMUNITIES AND ASSOCIATED FUNCTIONS TO TEMPERATURE AND FREEZE-THAW CYCLE FREQUENCY . 107 ABSTRACT . 107 INTRODUCTION . 108 MATERIAL AND METHODS . 110 RESULTS . 114 DISCUSSION . 119 ACKNOWLEDGEMENTS . 122. 107 INTRODUCTION . 108 MATERIAL AND METHODS . 110 RESULTS . 114 DISCUSSION . 119 ACKNOWLEDGEMENTS . 122 CHAPTER 7: RAPID ENVIRONMENT-SPECIFIC RESPONSES OF ANTARCTIC SOIL MICROBIAL COMMUNITIES AND FUNCTIONS TO SIMULATED GLOBAL WARMING . 123 ABSTRACT . 123 INTRODUCTION . 124 MATERIAL AND METHODS . 126 RESULTS . 130 DISCUSSION . 138 ACKNOWLEDGMENTS . 141. 123 INTRODUCTION . 124 MATERIAL AND METHODS . 126 RESULTS . 130 DISCUSSION . 138 ACKNOWLEDGMENTS . 141 CHAPTER 8: GENERAL DISCUSSION AND SYNTHESIS. 143 LATITUDINAL GRADIENT . 143 MICROCOSMS . 144 FIELD WARMING EXPERIMENT . 145 GLOBAL WARMING, ANTARCTICA AND SOIL MICROORGANISMS . 145 RE
Creative Management and Innovation: Building Competitive Advantage in The Contemporary Era

In the world of business and enterprise, competition is something that cannot be avoided. Especially in this contemporary era, business practices are experiencing very rapid changes due to advances in digital technology which requires business people to be ready to face competition. In an effort to face competition in business, an attitude of discipline, creativity and innovation is needed by business people or businesses. In an effort to maintain market share, an entrepreneur must be able to see an opportunity and have the courage to take a risk. It is through courage and opportunity that an entrepreneur becomes equipped to remain capable and even win market competition. This research aims to find out what kind of creativity and innovation are carried out by business actors in dealing with changes in market share in the current era. This research uses a qualitative research method using a case study approach. The results of this research are that the application of creative management and innovation carried out by the UMKM industry, Ms. Sumiatin's peanut brittle business and the restaurant industry, namely Lim's Cafe Kisaran and Bang Kendik Cafe Rantauparat, has had a positive impact and is able to create competitive advantages in the contemporary era.
Effect of different parameters on the serum levels of MDA, NBT, and NO in Andaman local goat breeds

The present study was carried out to assess the effect of rearing systems, breeds, number of pregnancies, and frequency of multiple births on physiological oxidative stress markers (OSMs) in indigenous goat breeds of Andaman and Nicobar Islands, India. Does (n=98) with more than one kidding record maintained in the organized goat breeding farm and at the farmer’s field were selected for the study. Pregnancy records were grouped as more than or less than three pregnancies. Breeds were grouped such as Andaman local goat (ALG) and other indigenous goat breeds. Birth frequency was grouped as single and multiple births. Oxidative stress markers such as malondialdehyde (MDA), superoxide anions, and nitric oxide were analysed in blood serum with respect to the different experimental variables. The free radical superoxide and endogenous nitrite values concerning the breed, multiple birth frequency, number of kidding, and rearing systems were non-significant. Lipid peroxidation through TBARS and nitrate values for the breed, multiple birth frequency, and rearing system were non-significant. However, the pregnancy-wise TBARS and nitrate concentration were significant. Estimates of TBARS were significantly high in the animals with lesser pregnancies (1-3 kidding) while nitrate concentration was significant in higher pregnancies (> 3 kidding). This study revealed that these experimental variables had considerable effects on OSMs in goat breeds under the hot humid tropical island ecosystem of Andaman and Nicobar Islands.
Analysis of the carbon dioxide concentration in the lowest atmospheric layers and the factors affecting China based on satellite observations

Carbon dioxide (CO2) is the most important anthropogenic greenhouse gas contributing to global climate change. SCIAMACHY on board ENVISAT (launched in 2002) is the first satellite instrument to monitor the changes in CO2 concentration in the lowest atmospheric layers. The temporal and spatial distribution of CO2 (2003–2009) concentration based on SCIAMACHY over China is presented and discussed. It shows an annual increase and a seasonal cycle. The CO2 annual growth rate was about 1.8 ppm year−1, with the highest value being in spring and the lowest in autumn. The CO2 concentration variation is determined by many complex factors. In this article, we analyse the important factors affecting CO2 variations, with special emphasis on terrestrial ecosystems and energy consumption. Terrestrial ecosystems are an important sink in the global carbon cycle. The relationship between CO2 concentration and Moderate Resolution Imaging Spectroradiometer (MODIS) net primary production (NPP) in 2008 is analysed. CO2 concentration is inversely proportional to NPP both in regions with high-density vegetation and in deserts. The Yunnan province has the highest NPP value and the lowest CO2 concentration, whereas the Takla Makan Desert has the lowest NPP value and the highest CO2 concentration. Energy consumption is the main emission source of atmospheric CO2. CO2 emissions from energy consumption show a steady increase in China since 1980. China's CO2 concentration variation shows a high correlation with energy consumption (coefficient of determination (R 2) > 0.8). The regions with high energy consumption are major industrial regions such as Shandong, Guangdong, Jiangsu, Zhejiang, Hebei, and Henan.
ICHNOLOGICAL RECORD OF ENVIRONMENTAL CHANGES IN EARLY QUATERNARY (GELASIAN–CALABRIAN) MARINE DEPOSITS OF THE STIRONE SECTION, NORTHERN ITALY

ABSTRACT Nineteen ichnotaxa occur in a 94-m-thick section of Gelasian–Calabrian siliciclastic deposits along the Stirone River. The most common trace fossils are grouped in 17 clusters based on a K-Means Cluster Analysis. This grouping is related to distal, archetypal and proximal Cruziana ichnofacies. Successions of ichnotaxa and clusters as represented in Detrended Correspondence Analyses determine environmental trends that helped establish a sequence stratigraphic scheme, which is not always obvious in the sedimentary record. The depositional sequences are separated by three sequence boundaries (A–C), which are well expressed in the ichnological record. Primary fabrics are less frequent in the archetypal and proximal Cruziana ichnofacies than in their idealized models. This is probably due to less intense storms in the small and protected paleo-Adriatic Sea and to intense bioturbation. Small-scale intervals with low ichnodiversity and ichnofabrics commonly dominated by one trace fossil are present. This suggests stressed conditions and opportunistic colonization related to small, but probably frequent, seafloor disturbances. The record of these disturbances— possibly caused by storm and bottom currents, deposition, or possibly erosion—has been obliterated by subsequent bioturbation. The disappearance of Schaubcylindrichnus, the smaller size of Scolicia and Ophiomorpha, and a slight decrease in trace fossil diversity in the Calabrian part of the section is interpreted to record climate cooling. This is also supported by the general decrease in ichnodiversity in Pleistocene versus Pliocene shallow-marine to slope siliciclastic facies.