Miracle-dz/UniFAR-FTUs huggingface dataset:
Amidst the Online Learning Modality: The Self-Efficacy and Its Relationship to the Academic Burnout of Senior High School Students

At all levels of the educational system, academic burnout has been a timely and significant problem among students, especially in online learning amidst COVID 19 pandemic. The sudden transition from face-to-face classes to online learning had made such meaningful impacts on students' efficacy and academe. Thus, students faced difficulties in adapting to the undesired and abrupt shift to online learning, which causes a lack of psychological capabilities to manage their academic needs, suffers a high level of academic stress and low efficacy, and gains vulnerability to psychosocial disturbances and burnout. This study aimed to investigate the relationship between self-efficacy and academic burnout among students here in the Philippines. The statistical findings show a significant relationship between self-efficacy and academic burnout (r = .168) with an associated probability value of 0.05 alpha level of significance.
Web-based Instruction: Analyzing students Satisfaction and Learning Interest

: The relationship between student satisfaction and learning interest when their instructor uses the web as a learning platform was investigated in this study. Respondents came from two colleges of Western Mindanao State University. The participants age ranges from 18 to 22 years old and completed an online questionnaire. The data in this research was analyzed using descriptive statistics, independent samples T-tests, and Pearson correlation. The findings of this study revealed that when a teacher uses web-based instruction, there is a favorable association between student satisfaction and learning interest. The findings suggest that student satisfaction has a beneficial impact on their learning interest and that the more frequently teachers use the internet and multimedia, the more satisfied and interested students are in learning social studies.
Research Progress in Isolation and Enrichment of Fetal Cells from Maternal Blood

Prenatal diagnosis is an important means of early diagnosis of genetic diseases, which can eﬀectively reduce the risk of birth defects. Free fetal cells, as a carrier of intact fetal genetic material, provide hope for the development of high-sensitivity and high-accuracy prenatal diagnosis technology. However, the number of fetal cells is small and it is diﬃcult to apply clinically. In recent years, noninvasive prenatal diagnosis (NIPD) technology for fetal genetic material in maternal peripheral blood has developed rapidly, which makes it possible to diagnose genetic diseases by fetal cells in maternal peripheral blood. This article reviewed the current status of fetal cell separation and enrichment technology and its application in noninvasive prenatal diagnosis technology.
Antagonistic Rhizobacteria as Natural Foes Producing Antioxidants Against Onion Pathogens During Storage

hree antagonists, i.e. Pseudomonas fluorescens , Bacillus subtilis and Serratia spp. , were tested either alone or as a mixture for suppression of onion neck rot and black mould diseases under field conditions. Samples were taken for determination of total phenols, cartenoides and flavonoids. The average of disease reduction was 18.75 % for mixture compared to 47.0% in the non-treated control. In addition to disease suppression, treatment with a mixture of the antagonists promoted plant growth in terms of increased bulb yield. The mixture of the tested bioagents was more effective in reducing the disease and promoting both plant growth and bulb yield compared with using each of them alone. The result indicated the biocontrol efficacy and storage stabilities were not increased with the enhancement of the concentration of biocontrol agents. Treatment the onion bulb with the bioagents increased cartenoides in mixture treatment and the fungicide Folucolon compared with the control and another tested treatment . Treatment onion bulb with any of the tested bioagents or their mixture decreased total phenols compared with the fungicide Folucolon and control in the two concentrations (10 8 CFU/ml and10 9 CFU/ml). On the other hand, they also increased flavonoids compared with control and the fungicide Folucolon in the two concentrations.
A Study on Information Literacy of Elementary School Teachers

: The fast development of the network has caused a great impact on teachers who engage in the forefront educational works. For conforming to the demand of the internet era, it is an inevitable trend to train the teachers themselves to acquire the basic information literacy. In order to provide references for relevant units to initiate teachers’ professional training programs, this study, through questionnaire, explored current situation about the information literacy of elementary teachers, and analyzed the relationship between the information literacy and the personal background. Based on the “The Indexes of Information Literacy of Teachers in Elementary and Secondary Schools” promulgated by the Ministry of Education, the questionnaire was developed and sent to 120 elementary teachers in Kaohsiung Taiwan. This research found that “professional literacy of information curriculum”, “operational literacy of computer software”, “basic literacy of the application to web-based instruction in disciplines”, and “whole information literacy” are related to sex, ages, total service years, and weekly hours of computer usage.
Therapeutics, Targets, Chemical Biology Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells

, Abstract Neuroblastoma (NB) is an often fatal pediatric tumor of neural crest origin. We previously isolated NB tumor-initiating cells (NB TIC) from bone marrow metastases that resemble cancer stem cells and form metastatic NB in immunodeficient animals with as few as ten cells. To identify signaling pathways important for the survival and self-renewal of NB TICs and potential therapeutic targets, we screened a small molecule library of 143 protein kinase inhibitors, including 33 in clinical trials. Cytostatic or cytotoxic drugs were identified that targeted PI3K (phosphoinositide 3-kinase)/Akt, PKC (protein kinase C), Aurora, ErbB2, Trk, and Polo-like kinase 1 (PLK1). Treatment with PLK1 siRNA or low nanomolar concentrations of BI 2536 or BI 6727, PLK1 inhibitors in clinical trials for adult malignancies, were cytotoxic to TICs whereas only micromolar concentrations of the inhibitors were cytotoxic for normal pediatric neural stem cells. Furthermore, BI 2536 significantly inhibited TIC tumor growth in a therapeutic xenograft model, both as a single agent and in combination with irinotecan, an active agent for relapsed NB. Our findings identify candidate kinases that regulate TIC growth and survival and suggest that PLK1 inhibitors are an attractive candidate therapy for metastatic NB. Cancer Res; 71(4); 1385 – 95. (cid:1) 2011 AACR.
N-acetyltransferase 2 genotypes amongst Zulu Speaking South Africans and isoniazid / N-acetyl-isoniazid pharmacokinetics during anti-tuberculosis treatment

Background Distribution of N-acetyltransferase2 (NAT2) polymorphisms varies considerably among different ethnic groups. Information on NAT2 single-nucleotide polymorphisms in South African population is limited. We investigated NAT2 polymorphisms and their effect on isoniazid pharmacokinetics in Zulu black HIV-infected South Africans in Durban, South Africa. Methods: HIV-infected participants with culture-confirmed pulmonary tuberculosis (TB) were enrolled from two unrelated studies. Culture-confirmed participants were genotyped for NAT2 polymorphisms 282C>T, 341T>C, 481C>T, 857G>A, 590G>A and 803A>G using Life Technologies pre-validated Taqman assays (Life Technologies, Paisley, UK). Participants underwent sampling for determination of plasma isoniazid and N-acetylisoniazid concentrations. Results Amongst the 120 patients, 63/120 (52.5%) were slow metabolisers (NAT2*5/*5), 43/120 (35.8%) had intermediate (NAT2*5/12), and 12/120 (11.7%) had rapid genotype (NAT2*4/*11, NAT2*11/12 and NAT2*12/12). NAT2 alleles in this study were *4, *5C, *5D, *5E, *5J, *5K, *5KA, *5T, *11A, *12A/12C and *12M. NAT2*5 was the most frequent allele (70.4%) followed by NAT2*12 (27.9%). 34/40 had both PK results and NAT2 genotyping results. The median area under the concentration-time-curve to infinity (AUC0-∞) interquartile range (IQR) was 7.81 (5.87 – 16.83) μg/ml/hr and maximum concentration (Cmax) 3.14 μg/ml (2.42 – 4.36) μg/mL. Individual polymorphisms were not equally distributed, with some represented in small numbers. Genotype did not correlate with phenotype, rapid genotype showing higher AUC0-∞ than slow but not significant, p=0.43. Conclusion There was high prevalence of slow followed by intermediate then rapid acetylator genotypes. The poor concordance between genotype and phenotype suggests that other factors or genetic loci influence INH metabolism, and warrants further investigation in this population.
Collateral Diversification Pitfalls and Systemically Important Merchant Banks

The persisting climate of financial market vulnerability in Europe has raised pressing questions about the viable options for policy makers and the operability of “traditional” policy instruments. Given the recent crisis and post-crisis experience, the momentum of the debate has from the outset centred on the interactions between the real and financial sectors. The efforts by researchers, industry experts and policy makers have ultimately transformed into a number of both theoretical and empirical studies (for a detailed survey see, for example, BIS, 2011), which either build upon existing channels or develop novel ones linking the real and financial sides of the economy. The influential balance sheet or “financial accelerator” framework of Bernanke and emphasises capital market frictions, including moral hazard, asymmetric information and imperfect contract enforcement problems, and the subsequent need for collateral to access credit.
Concurrent effects of attentional focus on postural sway during quiet standing in chronic stroke patients

:The purpose of this study was to investigate the effects of attentional focus on static postural control in chronic stroke patients. Twenty four subjects diagnosed with chronic stroke participated in the experiment. All subjects maintained quiet standing on a force plate for 30 s with three attentional focus conditions: baseline (BL), internal focus (IF), andexternal focus (EF). No instructions regarding attentional focus were given to the subjects for the BL condition. The subjects were instructed to stand with their attention focused on their feet for the IF condition. Under the EF condition, the subjects were first instructed to check red markers indicated on the force plate. Then the subjects were asked to look front but to concentrate on the markers. The results demonstrated that the EF condition reduced the amount and instability of postural sway more than the other attentional focus conditions. The effects of attentional focus on postural sway were only exhibited in the mediolateral direction. This study suggests that directing attention focused on the movement effect that occurs in the external environment around the body may help stroke patients enhance the postural control of quiet standing.This might result from reduced asymmetric weight distribution with external focus. The present results provide a possible use of external focus to stabilize static posture in physical therapy for patients with stroke.
E ﬀ ect of Nitrate and Perchlorate on Selenate Reduction in a Sequencing Batch Reactor

: Selenate removal from a water body is being vigorously debated owing to severe health impact, but inhibitions of coexisting anions have been reported. To suggest a viable treatment option, this study investigates the e ﬀ ect of nitrate and perchlorate on selenate reduction in a laboratory-scale sequencing batch reactor. The experimental design tests how competing electron acceptors (NO 3 − and ClO 4 − ) and electron donor (acetate) limitations a ﬀ ect selenate reduction in the reactor. Results show that the reactor achieves almost complete selenate reduction within the initial concentration ranges of 0.1–1 mM by enriching selenate-reducing bacteria with appropriate temperature (30 ◦ C) and acclimation period (50 days). We monitored simultaneous selenate and nitrate reduction in the reactor without speciﬁc inhibition due to a di ﬀ erence in microbial growth strategy related to electron donor status. Lack of perchlorate-reducing bacteria makes perchlorate addition (0.2 mM) not to be closely associated with dissimilative perchlorate reduction. These results provide information that can help us to understand the e ﬀ ect of competing electron acceptors on selenate reduction and the kinetics of potential parallel reactions in the reactor.
The Japanese Circulation Journal

specifically in lymphatic t三ssues couid bc produced by lymphotoxins and so forth. Prof. 八{aekawa prcdicted from his own new theory on a 重lergy that the phos− phatide of iy興phocyte or lymphnodc would act as a determinant group in the specific allc 貰gic changes of lymphatic tissues. In order to ascertain thc r61e of lymphnode phos・ photidc, I pcrformed scvcral experimcnts , using var − ious cumbinat 三〇 ns of phosphatides and ox sera for sens 量t呈zation and reinjecti n. Thc rcsults of these exper 五ments seem to sllow that the lymphnode phos・ photide acts as a ‘hapten ア’ . The phosphatide is con 卩
DDDT_A_332729 4229..4242

1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza, Egypt Significance: Statins are an important class of drugs that help to control hyperlipidemia, and one of these statins recently used is pitavastatin calcium (PITA). Nevertheless, the most reported adverse effect of statins is myopathy. Therefore, combining statins with nonsteroidal anti-inflammatory drugs (NSAIDs) as Lornoxicam (LORNO) can help in the management of statin-induced myopathy. Purpose: This study aimed to formulate and evaluate different oral disintegrating tablets (ODTs) containing PITA using different co-processed excipients. The best PITA-ODT was selected and reformulated with the addition of LORNO, forming a single ODT comprising both drugs. The pharmacokinetic parameters of PITA and LORNO in a single ODT were compared to those of the marketed products (Lipidalon and Lornoxicam). Methods: Eight PITA-ODTs were prepared via direct compression. The prepared PITAODTs were evaluated for their weight variation, thickness, breaking force, friability, drug content, and wetting time (WT). In-vitro disintegration time (DT) and dissolution were also evaluated and taken as parameters for selection of the best formula based on the criteria of scoring the fastest DT and highest Q10 min. LORNO was added to the selected PITA-ODT, forming a single ODT (M1) comprising both drugs, which was subjected to an in-vivo pharmacokinetic study using rats as an animal model and liquid chromatography-mass spectrometry (LC-MS/MS) for analysis of both drugs in rat plasma. Results: Results showed that all PITA-ODTs had acceptable physical properties in accordance with pharmacospecial standards. PITA-ODT prepared with Pharmaburst (F2) had significantly (p<0.05) the fastest DT (6.66±1.52 s) and highest Q10 min (79.07±2.02%) and was chosen as the best formula. The in-vivo pharmacokinetic study of M1 formula showed higher percent relative bioavailability (%RB) of 286.7% and 169.73% for PITA and LORNO, respectively, compared with the marketed products. Conclusion: The single ODT comprising PITA and LORNO was promising for instant codelivery of both drugs with higher %RB when compared with the marketed products.
Self-Assembly in High Films with Ru-Based Double

: Many second phase additions to YBa 2 Cu 3 O 7 − x (YBCO) films, in particular those that self-assemble into aligned nanorod and nanoparticle with such a distribution of secondary phases was found to have reduced self-field J c values of 3.4 MA/cm 2 at 75.5 K and J c (min, Θ , 1T) of 0.4 MA/cm 2 .
Evaluating metabolites in patients with major depressive disorder who received cognitive therapy and healthy controls using short echo MRSI at 7

mindfulness-based Tesla. of N -acetyl aspartate (NAA)/tCr in the left ACC, myo-inositol/tCr in the right insula, and glutathione/tCr in the left putamen were significantly decreased. At baseline, the severity of depression was negatively correlated with my-inositol/tCr in the left insula and putamen. The improve-ment in depression severity was significantly associated with changes in NAA/tCr in the left ACC. Conclusions This study has successfully evaluated regional differences in metabolites for patients with MDD who received MBCT treatment and in controls using 7 Tesla MRSI. its efficacy in reducing depressive recurrence [2] and treat-ing acute [3], chronic [4], and treatment-resistant depression [5] as an augmentation. These findings make MBCT treatment a potential valuable stand-alone treatment for MDD. Abstract Objectives Our aim was to evaluate differences in metabolite levels between unmedicated patients with major depressive disorder (MDD) and healthy controls, to assess changes in metabolites in patients after they completed an 8-week course of mindfulness-based cognitive therapy (MBCT), and to exam the correlation between metabolites and depression severity.
In-vitro activity of ﬂuorinated quinolones and macrolides against drug-resistant Mycobacterium tuberculosis

Working 40 the ﬁnal concentrations prepared by diluting the stock solutions with water. They were kept frozen at until used. Final concentrations in the test vials were 1, 2, 4 and 8 mg/L of the and 2, 4, 8 and 16 mg/L of the macrolides, thus covering the concentrations deﬁned as breakpoints for in-vitro susceptibility testing of bacterial pathogens according the National Committee for Clinical Laboratory The increasing incidence of drug-resistant Mycobacterium tuberculosis necessitates therapeutic alternatives. The in-vitro activities of seven ﬂuoroquinolone and macrolide compounds were tested against 23 clinical isolates of M. tuberculosis , including 17 multidrug-resistant strains. Sparﬂoxacin was the most active ﬂuoroquinolone, with MICs of 1 mg/L for all tested strains, followed by levoﬂoxacin and ciproﬂoxacin. Trovaﬂoxacin had no inhibitory activity at the concentrations tested. The MICs of the macrolides were generally higher, clarithromycin
Knowledge and Attitude of Tuberculosis Patients and Their Family Caregivers about Tuberculosis in Minia Governorate

: Background: Tuberculosis continues to pose serious public health problem threats, especially in developing countries. It is a common and often deadly infectious disease caused by mycobacteria, usually Mycobacterium tuberculosis in humans. Tuberculosis usually attacks the lungs but can also affect other parts of the body. Each year, approximately 2 million persons worldwide die of tuberculosis and 9 million become infected. Aim of this study: to assess knowledge and attitude of TB patients and their family caregivers about TB in Minia governorate. Subject and Methods: Cross sectional research design was utilized in the present study. This study was carried out in Minia governorate; three districts namely Beni-mazar, Minia and Mallawy that were selected randomly. The study sample included 125 patients' and 173 family caregivers. Two tools were used in this study. First tool: consists of three parts: Part I; included sociodemographic characteristics , Part II; included environmental assessment sheet. Part III; included Knowledge of patient and their families about Tuberculosis disease. Second tool: Likert scale used to assess attitude of patients and their families about tuberculosis. Results: This study illustrated that the age of TB patients and their family caregivers ranged between (18-60) years with the mean age (34.8±13.7, 38.8±13.9), respectively. Concerning the educational level, it was found that the highest percentage in both groups were illiterate, it represents 43.2% in the TB patients and 43.9% in the family caregivers, respectively. Also, the present study showed that the majority of TB patient and their families had poor knowledge and negative attitude about TB. Conclusion: the findings of this study illustrated that more than half of patient and their families had poor knowledge about TB and more than three quarters of them had negative attitude especially in rural areas. Recommendation: there is a strong need for increasing patients and family caregiver’s awareness about TB transmission and prevention.
Nanoparticle interactions with blood proteins and what it means: a tutorial review

Nanoparticles find many uses in medicine and biomedical technology. Such applications imply that they must be colloidally stable and do not interact with proteins in the blood or blood serum. A nanoparticle put into the blood will instantaneously be covered by a protein corona that compromises the function of the nanoparticle core, changes the effective size of the nanoparticle, and determines its biological fate. Strategies developed to gain control over nanoparticles in biological fluids, particular in blood, heavily rely on creating a hydrated polymer shell that sterically and osmotically prevents a protein corona from forming. In this tutorial review, we provide an over-view of factors that affect the formation of the protein corona in blood and how to prevent it forming. We focus on describing the latest advances in our understanding of how small core - shell nanoparticles (core diameter 4-20 nm in diameter) with a shell of densely grafted polymer chains, a so - called polymer brush, interact with proteins and cells in vitro . Such nanoparticles are among the most well - defined and well - characterized colloids used for biomedical applications, from which an improved understanding of how nanoparticle architecture influences their biological fate can be obtained in detail. of stickier but less abundant proteins lead to the creation of a hard corona. On the hard corona, a new soft corona can form in dynamic equilibrium with the pool of proteins in the blood.