Miracle-dz/UniFAR-FTUs huggingface dataset:
Production , Manufacturing and Logistics On the empirical performance of ( T , s , S ) heuristics

0377-2217/$ see front matter 2009 Elsevier B.V. A doi:10.1016/j.ejor. 2009.05. 030 * Corresponding author. Tel. : +33 5 56 84 55 55. E-mail address: mohamed-zied.babai@bem.edu (M The periodic ðT; s; SÞ policies have received considerable attention from the academic literature. Determination of the optimal parameters is computationally prohibitive, and a number of heuristic procedures have been put forward. However, these heuristics have never been compared in an extensive empirical study. Such an investigation on 3055 SKUs is carried out in this paper. Our study provides insights into the performance of ðT; s; SÞ heuristics, also in relation to demand forecasting. The results show that Naddor’s heuristic is best able to minimize the total cost. However, the normal and power approximations achieve more efficient solutions in that backorder volumes are smaller at the same inventory levels, indicating the potentially superior performance of these methods if the balancing of holding and backorder costs can be improved. The results also show that, for all heuristics, the SBA variant of the Croston forecasting method significantly outperforms Croston as well as Single Exponential Smoothing (SES). 2009 Elsevier B.V. All rights reserved.
Cognitive function and fatigue after diagnosis of colorectal cancer.

BACKGROUND Cognitive impairment and fatigue have been associated with cancer and its treatment. We present baseline data from a large longitudinal study that evaluates cognitive function, fatigue, and potential underlying mechanisms following diagnosis of colorectal cancer (CRC). PATIENTS AND METHODS We evaluated CRC patients with stage I-III disease before or after surgery, participants with limited metastatic disease and healthy controls (HC). Neuropsychological evaluation included clinical and computerised tests. Participants completed questionnaires for fatigue and quality of life (QOL)-(FACT-F), anxiety/depression, and cognitive symptoms (FACT-Cog). Ten cytokines, clotting factors, sex hormones, carcinoembryonic antigen (CEA), and apolipoprotein E genotype were evaluated. Primary end points were cognitive function on clinical tests evaluated by a Global Deficit score (GDS) and fatigue. Associations between test results, demographic, and disease related factors were explored. RESULTS We assessed 291 participants with early-stage disease [median age 59 (23-75) years, 63% men], 72 with metastatic disease, and 72 HC. Using GDS, 45% (126/281) of participants with early-stage CRC had cognitive impairment versus 15% (11/72) of HC (odds ratio 4.51, 95% confidence interval 2.28-8.93; P < 0.001), with complex processing speed, attention/working memory, and verbal learning efficiency being most affected. Women with early-stage CRC had greater cognitive impairment than men [55/105 (52%) versus 71/176 (40%), P < 0.050]. Cognitive symptoms were self-reported by 21% (59/286) of early-stage patients versus 17% (12/72) of HC; fatigue by 52% (149/287) of early-stage patients and 26% (19/72) of HC (P < 0.0001). Women reported more fatigue than men (P = 0.003). Fatigue, QOL, anxiety/depression, and cognitive symptoms were associated with each other (r = 0.43-0.71), but not with neuropsychological performance. Most cytokines were elevated in cancer patients. Cognitive function was not associated with cytokines, sex hormones, clotting factors, CEA, or apolipoprotein E genotype. CONCLUSIONS The incidence of cognitive impairment was three to five times higher in CRC patients than HC, with women having higher impairment rates than men. The cognitive impairment profile suggests dysfunction primarily in fronto-subcortical brain systems. TRIAL REGISTRATION NCT00188331.
The New Modular Control System for Power Converters at CERN

The CERN accelerator complex consists of several generations of particle accelerators, with around 5000 power converters supplying regulated current and voltage to normal and superconducting magnet circuits. Today around 12 generations of converter control platforms can be found in the accelerator complex, ranging in age and technology. The diversity of these platforms has a significant impact on operability, maintenance and support of power converters. Over the past few years a new generation of modular controls called RegFGC3 has been developed by CERN’s power conversion group, with a goal to provide a standardised control platform, supporting a wide variety of converter topologies. The aim of this project is to reduce maintenance costs by decreasing the variety and diversity of control systems whilst simultaneously improving the operability and reliability of power converters and their controls. This paper describes the state of the on-going design and realization of the RegFGC3 platform, focusing on functional requirements using Thyristor based converters as an example. Presented at ICALEPCS, 17-23 October 2015, Melbourne, Australia Geneva, Switzerland October, 2015 THE NEW MODULAR CONTROL SYSTEM FOR POWER CONVERTERS AT CERN M. Di Cosmo, B. Todd CERN, Geneva, Switzerland
Exploring a New Therapy for Diabetic Polyneuropathy – The Application of Stem Cell Transplantation

Diabetic polyneuropathy (DPN) is the most common complication that emerges early in diabetic patients. Intervention with strict blood glucose control or treatment with aldose reductase inhibitor is reported to be effective in early stages of DPN. Curative treatment for overt or symptomatic DPN, however, has not been established, thus requiring much effort to explore a new therapy. Recent preclinical studies on the use of gene or cell therapy have provided promising results in the treatment of DPN. Of particular interest, induced pluripotent stem cells are introduced. In these studies, restoration of DPN was proposed to be attributed to either neurotrophic factors released from transplanted stem cells or differentiation of stem cells to substitute the damaged peripheral nerve. There are still several problems, however, that remain to be overcome, such as perturbed function, fragility, or limited survival of transplanted cells in diabetes milieu and risk for malignant transformation of transplanted cells. Questions, which cell is the most appropriate as the source for cell therapy, or which site is the best for transplantation to obtain the most effective results, remain to be answered. In this communication, we overview the current status of preclinical studies on the cell therapy for DPN and discuss the future prospect.
Gravitational Lensing Effect on the Two-Point Correlation of Hot Spots in the Cosmic Microwave Background

We investigate the weak gravitational lensing effect that is due to the large-scale structure of the universe on two-point correlations of local maxima (hot spots) in the two-dimensional sky map of the cosmic microwave background (CMB) anisotropy. According to the Gaussian random statistics, as most inflationary scenarios predict, the hot spots are discretely distributed, with some characteristic angular separations on the last scattering surface that are due to oscillations of the CMB angular power spectrum. The weak lensing then causes pairs of hot spots, which are separated with the characteristic scale, to be observed with various separations. We found that the lensing fairly smooths out the oscillatory features of the two-point correlation function of hot spots. This indicates that the hot spot correlations can be a new statistical tool for measuring the shape and normalization of the power spectrum of matter fluctuations from the lensing signatures.
A Symbolic Labelled Transition System for Coinductive Subtyping of Fµ< Types

F is a typedλ-calculus with subtyping and bounded polymorphism. Typechecking for F is known to be undecidable, because the subtyping relation on types is undecidable. F μ is an extension of F with recursive types. In this paper, we show how symbolic labelled transition system techniques from concurrency theory can be used to reason about subtyping for F μ . We provide a symbolic labelled transition system for F μ types, together with an an appropriate notion of simulation, which coincides with the existing coinductive definition of subtyping. We then provide a ‘simulation up to’ technique for proving subtyping, for which there is a simple model checking algorithm. The algorithm is more powerful than the usual one for F , for example it terminates on Ghelli’s canonical example of nontermination.
Attitudes Toward a Game-Based Approach to Mental Health

Based on preliminary research, game-based treatments appear to be a promising approach to post-traumatic stress disorder (PTSD). However, attitudes toward this novel approach must be better understood. Thus, the objective of this study was to determine if video game self-efficacy mediates the relationship between expectations and reactions to a game-based treatment for PTSD. Participants played the serious game "Walk in My Shoes" (Novonics Corp., Orlando, FL) and completed a series of scales to measure attitudes toward the intervention. Video game self-efficacy was found to be a partial mediator of expectancies and reactions. These results suggest that enhancing attitudes via self-efficacy in a clinical setting may maximize treatment effectiveness.
App store mining and analysis: MSR for app stores

This paper introduces app store mining and analysis as a form of software repository mining. Unlike other software repositories traditionally used in MSR work, app stores usually do not provide source code. However, they do provide a wealth of other information in the form of pricing and customer reviews. Therefore, we use data mining to extract feature information, which we then combine with more readily available information to analyse apps' technical, customer and business aspects. We applied our approach to the 32,108 non-zero priced apps available in the Blackberry app store in September 2011. Our results show that there is a strong correlation between customer rating and the rank of app downloads, though perhaps surprisingly, there is no correlation between price and downloads, nor between price and rating. More importantly, we show that these correlation findings carry over to (and are even occasionally enhanced within) the space of data mined app features, providing evidence that our `App store MSR' approach can be valuable to app developers.
Scanning polyhedra with DO loops

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Scanning polyhedra with DO loops Corinne Ancourt, François Irigoin
Impact of Urbanization on the Spatial Sustainability of A City - A Case Study of Yantai

Urbanization is a major factor that shapes the pattern of urban area of cities and exerts influence on cities’ development. The pattern of urban expansion and sprawl is considered as the main feature for evaluating the development of a city, which can dramatically reflect the path of urbanization and largely influence the potential of sustainability of a city. The objectives of this study were to introduce a sustainable development indicator - compact coefficient of urban area (CCUA), specially designed for evaluating the sustainability of a city in spatial dimension, and reveal the impact of urbanization on the sustainability of a city through comparing the trend of urbanization rate of a city with its changes of CCUA. A case study has been taken in Yantai, a medium-sized city in east part of China. Remote sensing was used for mapping the land use/land cover changes of urban area in Yantai from 1990 to 2010 by using the medium-resolution satellite imagery. Then, five indexes of ecological landscape were selected and processed, and CCUA of Yantai was calculated. Results of this study indicate that CCUA is an efficient indicator for measuring the sustainability of the pattern of urban expansion, which can assist the urban planning process of professionals and facilitate the decision-making process of local government.
Visualization of Publication Impact

Measuring scholarly impact has been a topic of much interest in recent years. While many use the citation count as a primary indicator of a publications impact, the quality and impact of those citations will vary. Additionally, it is often difficult to see where a paper sits among other papers in the same research area. Questions we wished to answer through this visualization were: is a publication cited less than publications in the field? ; is a publication cited by high or low impact publications? ; and can we visually compare the impact of publications across a result set? In this work we address the above questions through a new visualization of publication impact. Our technique has been applied to the visualization of citation information in InspireHep (www.inspirehep.net), the largest high energy physics publication repository.
Structure and mechanical properties in drawn poly(l‐lactide)/clay hybrid films

Films composed of poly(l-lactide) (PLLA)/organophilic montmorillonite hybrids (PLACHs) have been prepared via a melt-compounding process, which is followed by uniaxial drawing at 90°C in air. In addition, an enhancement of the mechanical properties of these drawn PLACH films, which is expected to differ depending on the drawn ratios, is also estimated by dynamic viscoelastic measurements. Three different organoclay concentrations in the hybrid of 3, 5, and 9 wt% were investigated. The structural parameters for the PLLA crystallites in the drawn films, such as the c-axis orientation function (fPLLA) and crystallite size, were measured by X-ray diffraction, and their drawn ratio (λ) and clay concentration dependence were examined from a textural viewpoint. Another orientation function (fclay) of the organoclay particles was obtained by transmission electron microscopy (TEM). The values of fPLLA and crystallinity for PLLA sharply increased with λ for λ 5), the organoclay particles in the PLACHs started orienting themselves parallel to the draw direction. Copyright © 2008 John Wiley & Sons, Ltd.
Microsatellite markers for Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) and other Cryptolestes species

Abstract Cryptolestes ferrugineus (Stephens, 1831) is an important insect pest of stored products. Due to its broad host range, short life cycle, and high reproductive capacity, this species has rapidly colonized temperate and tropical regions around the world. In this study, we isolated 18 novel polymorphic microsatellite loci from an enriched genomic library based on a biotin/streptavidin capture protocol. These loci will be useful tool to better understand the genetic structure and migration patterns of C. ferrugineus throughout the world. The genetic parameters were estimated based on 80 individual C. ferrugineus from two natural populations. The results revealed that 18 loci were different polymorphic levels. The numbers of alleles ranged from 3 to 12, and eleven loci demonstrated polymorphic information contents greater than 0.5. The observed (H O) and expected (H E) heterozygosities ranged from 0.051 to 0.883 and 0.173 to 0.815, respectively. Five locus/population combinations significantly deviated from Hardy–Weinberg equilibrium. We also demonstrated the potential utility of the C. ferrugineus microsatellites as population and species markers for four additional Cryptolestes species.
Comparing Surface and Mid-Tropospheric CO2 Concentrations from Central U.S. Grasslands

Comparisons of eddy covariance (EC) tower measurements of CO2 concentration with mid-tropospheric observations from the Atmospheric Infrared Sounder (AIRS) allow for evaluation of the rising global signal of this greenhouse gas in relation to surface carbon dynamics. Using an information theory approach combining relative entropy and wavelet multi-resolution analysis, this study has explored correlations and divergences between mid-tropospheric and surface CO2 concentrations in grasslands of northeastern Kansas. Results show that surface CO2 measurements at the Kansas Field Station (KFS) and the Konza Prairie Biological Stations 1B (KZU) and 4B (K4B) with different land-cover types correlate well with mid-tropospheric CO2 in this region at the 512-day timescale between 2007 and 2010. Relative entropy further reveals that AIRS observations are indicative of surface CO2 concentrations for all land-cover types on monthly (32-day) and longer timescales. AIRS observations are also similar to CO2 concentrations at shorter timescales at sites KFS and K4B experiencing woody encroachment, though these results require further investigation. Differences in species composition and microclimate add to the variability of surface concentrations compared with mid-tropospheric observations.
Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer.

PURPOSE Because survival for patients with oral cancer has not improved over the past 25 years, new approaches for treatment are needed. Targeted molecular therapy against epidermal growth factor receptor (EGFR) has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. The objective of this study was to determine the efficacy of paclitaxel and PKI166, a novel inhibitor of EGFR, against oral cavity cancer. EXPERIMENTAL DESIGN AND RESULTS JMAR human oral cancer cells were pretreated for 1 h with PKI166 and then stimulated with epidermal growth factor. EGFR-specific tyrosine kinase autophosphorylation measured by Western immunoblotting was inhibited by PKI166 in a dose-dependent fashion at all doses tested (0.01-1 micro M). Next, the induction of apoptosis in JMAR cells treated with paclitaxel (0.001 to 0.1 micro M) with or without PKI166 (0, 1, or 2 micro M) was determined using a propidium iodide assay. The addition of 2.0 micro M PKI166 significantly increased tumor cell death, shifting the amount of paclitaxel needed to induce apoptosis in 50% of cells from 0.1 to 0.001 micro M. These in vitro findings were confirmed using an orthotopic model of oral cancer. JMAR oral cancer cells were implanted into the tongues of nude mice. After lingual tumors developed, mice were randomized into four groups (n = 10): (a) oral PKI166 (100 mg/kg); (b) i.p. paclitaxel (200 micro g/wk); (c) PKI166 and paclitaxel; or (d) placebo. Mice treated with PKI166/paclitaxel demonstrated a significant increase in survival (P = 0.028). After necropsy, all tongue tumors were evaluated for apoptosis by the terminal deoxynucleotidyl transferase-mediated nick end labeling assay. A greater apoptotic fraction of tumor cells was found in tumors of mice treated with paclitaxel and PKI166 as compared with the other treatment groups (136.4 versus 37.8; P = 0.016). CONCLUSIONS Combination therapy with paclitaxel and PKI166 prolongs survival in an orthotopic preclinical model of tongue cancer by increasing programmed cell death of oral cancer.
Graph classes with given 3‐connected components: Asymptotic enumeration and random graphs

Consider a family \documentclass{article}\usepackage{mathrsfs, amsmath, amssymb}\pagestyle{empty}\begin{document}\begin{align*}\mathcal{T}\end{align*}\end{document} of 3‐connected graphs of moderate growth, and let \documentclass{article}\usepackage{mathrsfs, amsmath, amssymb}\pagestyle{empty}\begin{document}\begin{align*}\mathcal{G}\end{align*}\end{document} be the class of graphs whose 3‐connected components are graphs in \documentclass{article}\usepackage{mathrsfs, amsmath, amssymb}\pagestyle{empty}\begin{document}\begin{align*}\mathcal{T}\end{align*}\end{document}. We present a general framework for analyzing such graphs classes based on singularity analysis of generating functions, which generalizes previously studied cases such as planar graphs and series‐parallel graphs. We provide a general result for the asymptotic number of graphs in \documentclass{article}\usepackage{mathrsfs, amsmath, amssymb}\pagestyle{empty}\begin{document}\begin{align*}\mathcal{G}\end{align*}\end{document}, based on the singularities of the exponential generating function associated to \documentclass{article}\usepackage{mathrsfs, amsmath, amssymb}\pagestyle{empty}\begin{document}\begin{align*}\mathcal{T}\end{align*}\end{document}. We derive limit laws, which are either normal or Poisson, for several basic parameters, including the number of edges, number of blocks and number of components. For the size of the largest block we find a fundamental dichotomy: classes similar to planar graphs have almost surely a unique block of linear size, while classes similar to series‐parallel graphs have only sublinear blocks. This dichotomy was already observed by Panagiotou and Steger [ 25 ], and we provide a finer description. For some classes under study both regimes occur, because of a critical phenomenon as the edge density in the class varies. Finally, we analyze the size of the largest 3‐connected component in random planar graphs. © 2012 Wiley Periodicals, Inc. Random Struct. Alg. , 42, 438–479, 2013
Towards effective browsing of large scale social annotations

This paper is concerned with the problem of browsing social annotations. Today, a lot of services (e.g., Del.icio.us, Filckr) have been provided for helping users to manage and share their favorite URLs and photos based on social annotations. Due to the exponential increasing of the social annotations, more and more users, however, are facing the problem how to effectively find desired resources from large annotation data. Existing methods such as tag cloud and annotation matching work well only on small annotation sets. Thus, an effective approach for browsing large scale annotation sets and the associated resources is in great demand by both ordinary users and service providers. In this paper, we propose a novel algorithm, namely Effective Large Scale Annotation Browser (ELSABer), to browse large-scale social annotation data. ELSABer helps the users browse huge number of annotations in a semantic, hierarchical and efficient way. More specifically, ELSABer has the following features: 1) the semantic relations between annotations are explored for browsing of similar resources; 2) the hierarchical relations between annotations are constructed for browsing in a top-down fashion; 3) the distribution of social annotations is studied for efficient browsing. By incorporating the personal and time information, ELSABer can be further extended for personalized and time-related browsing. A prototype system is implemented and shows promising results.
On the moderating role of age in the relationship between pain and cognition

A relationship between pain perception and cognitive function is evident. However, the directionality of this association is unclear and may be influenced by age. That is, inverse associations between pain and cognition have been reported in young and middle‐aged chronic pain patients, whereas higher clinical pain ratings have been associated with better cognitive performance in older chronic pain patients. Therefore, this study examined the possible moderating role of age in the pain‐cognition relationship.