Miracle-dz/UniFAR-FTUs huggingface dataset:
CMAR_A_294584 2835..2848

1Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt; 2Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt; 3Surgical Oncology Department, Materia Teaching Hospital, Cairo, Egypt; 4Biostatistics and Epidemiology Department, National Cancer Institute, Cairo University, Cairo, Egypt; 5Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt; 6Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA, USA; 7Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt; 8Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093, USA; 9Department of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA; 10Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA Background: Mouse mammary tumor virus (MMTV) is thought to have a role in human breast cancer (BC) pathogenesis. BRCA1 and 2 genes mutations are well-established risk factors for BC. The purpose of this study was to evaluate the presence of MMTV in familial and non-familial Egyptian breast cancer patients. We also aimed to establish a correlation between BRCAs genes mutations and MMTV infection in those patients. Patients and Methods: The study was included 80 BC patients and 10 healthy women were included as a control group. We used PCR to amplify a 250-bp MMTV-like env sequence. We also used PCR followed by direct sequencing to identify the genetic variation of exons 2, 13, 19 of BRCA1 gene and exon 9 and region f of exon 11 of BRCA2 gene. High resolution melting (HRM) analysis was used to screen the selected exons of BRCA1/2 genes in order to detect different variants. Results: MMTV DNA-like env sequences were detected in 70%, 76% of familial and nonfamilial BC patients, respectively, and it was not detected in any of the control subjects. The presence of viral sequences was associated with larger tumor size in the sporadic patients. Seventy BC patients showed variations in BRCA1/2 genes according to HRM analysis and sequencing analysis showed two different sequences of polymorphism among 22 familial and non-familial BC patients. Conclusion: MMTV DNA was present among BC patients and it was associated with increased tumor growth. This indicates a potential role for MMTV in BC patients with and without deleterious mutation in BRCA1/2 genes.
Computer-Vision Based Expression Recognition in Classroom

– Human emotional facial expressions play an important role in interpersonal relations. This is because humans demonstrate and convey a lot of evident information visually rather than verbally. Although humans recognize facial expressions virtually without effort or delay, reliable expression recognition by machine remains a challenge as of today. To automate the recognition of the emotional state, machines must be taught to understand facial gestures. This paper gives a survey of different techniques for recognizing facial expression. The abstract view of the proposed system is given here for recognizing the emotions with higher accuracy. It helps to detect the face from the input image using Haar-Cascade face detection algorithm and to evaluate the face and Emotion from Students Face using the SVM classifier.
Low levels of faecal cortisol in bank voles (Myodes glareolus) in response to live-trapping

Small mammal trapping is a commonly taught field technique in ecology and population biology. However, there are still open questions regarding the extent to which trapping affects the welfare of small animals. This study investigated faecal cortisol as a non-invasive measurement of the physiological stress response of bank voles (Myodes glareolus) to live-trapping. Faecal cortisol concentrations were similar between samples collected from trapped and non-trapped voles, but were negatively correlated with capture duration. This result may suggest that any physiological stress response was short-lasting and the animals habituated to the trap. As such, effects on faecal cortisol were not apparent as mean faecal cortisol concentration was determined from multiple collected faeces. Future work should focus on characterising the potential stress response to trapping with greater temporal resolution.
RRU_A_241961 167..174

Radboudumc, Department of Primary and Community Care/Gender & Women’s Health, Nijmegen, the Netherlands Background: Lower urinary tract symptom (LUTS) is a common condition in older men. In accordance with the Dutch College of General Practitioners Guideline “Micturition symptoms in men”, the diagnosis can be made based on a patient’s medical history and a physical examination. GPs lack additional tools in primary care to assess the residual urine volume. A residual volume usually requires a referral to a urologist. We hypothesized that the IPSS screening questionnaire score (measuring the severity of symptoms) might be related to patients’ residual urine volume. The research objective was to examine the relation between the IPSS score and the residual urine volume. Methods: In a cross-sectional study, we analysed patients’ IPSS and residual urine volume. Men aged over 50 with LUTS who consulted Dutch primary-care physicians were included. The interventions comprised an IPSS screening and a bladder scan. Data regarding the patients’ residual volume, total IPSS score, single IPSS score, IPSS storage score, and IPSS voiding score were recorded and analysed. We used odds ratios to describe the relation between the IPSS categories associated with the presence of a normal or abnormal (above 100 cc and above 200 cc) residual urine volume. Results: A total of 126 patients were included in this study. Patients with higher scores on the overall IPSS, separate IPSS, IPSS storage and IPSS voiding showed no higher odds ratios of having an abnormal residual volume, neither above 100 mL or 200 mL. Conclusion: We did not find a relation between the IPSS core to an abnormal residual urine volume in men aged over 50 with LUTS consulting primary-care physicians. Trial Registration: This study has been approved by the Central Committee on Research Involving Human Subjects for the Arnhem-Nijmegen Region and is registered with ToetsingOnline under ID number 29822.091. 10.
Abnormal Pap Follow-Up among Criminal-Legal Involved Women in Three U.S. Cities

Criminal-legal involved women experience significant barriers to preventive cervical care, and consequently there is a higher incidence of cervical cancer in this population. The purpose of this study is to identify variables that may facilitate abnormal Pap follow-up among criminal-legal involved women living in community settings. The study included n = 510 women with criminal-legal histories, from three U.S. cities—Birmingham, AL; Kansas City, KS/MO; Oakland, CA. Participants completed a 288-item survey, with questions related to demographics, social advantages, provider communication, and reasons for missing follow-up care. There were n = 58 women who reported abnormal Pap testing, and n = 40 (69%) received follow-up care. Most women received either repeat Pap/HPV testing (n = 15, 38%), or colposcopy and/or biopsy (n = 14, 35%). Women who did not follow-up (n = 15, 26%) cited that they forgot (n = 8, 53%), were uninsured (n = 3, 20%), or were reincarcerated (n = 3, 20%). In a multivariate analysis, both having a primary care provider (OR 4.6, 95% CI 1.3–16.0) and receiving specific provider communication about follow-up (OR 3.8, 95% CI 1.1–13.2) were independent predictors for abnormal Pap follow-up. Interventions that offer linkages to providers in the community or ensure abnormal Pap care plans are communicated effectively may mitigate the disparate incidence of cervical cancer among criminal-legal involved women.
App-based COVID-19 surveillance and prediction: The COVID Symptom Study Sweden

Background The response of the Swedish authorities to the COVID-19 pandemic was less restrictive than in most countries during the first year, with infection and death rates substantially higher than in neighbouring Nordic countries. Because access to PCR testing was limited during the first wave (February to June 2020) and regional data were reported with delay, adequate monitoring of community disease spread was hampered. The app-based COVID Symptom Study was launched in Sweden to disseminate real-time estimates of disease spread and to collect prospective data for research. The aim of this study was to describe the research project, develop models for estimation of COVID-19 prevalence and to evaluate it for prediction of hospital admissions for COVID-19. Methods We enrolled 143 531 study participants ([≥]18 years) throughout Sweden, who contributed 10.6 million daily symptom reports between April 29, 2020 and February 10, 2021. Data from 19 161 self-reported PCR tests were used to create a symptom-based algorithm to estimate daily prevalence of symptomatic COVID-19. The prediction model was validated using external datasets. We further utilized the model estimates to forecast subsequent new hospital admissions. Findings A prediction model for symptomatic COVID-19 based on 17 symptoms, age, and sex yielded an area under the ROC curve of 0.78 (95% CI 0.74-0.83) in an external validation dataset of 943 PCR-tested symptomatic individuals. App-based surveillance proved particularly useful for predicting hospital trends in times of insufficient testing capacity and registration delays. During the first wave, our prediction model estimates demonstrated a lower mean error (0.38 average new daily hospitalizations per 100 000 inhabitants per week (95% CI 0.32, 0.45)) for subsequent hospitalizations in the ten most populated counties, than a model based on confirmed case data (0.72 (0.64, 0.81)). The model further correctly identified on average three out of five counties (95% CI 2.3, 3.7) with the highest rates of hospitalizations the following week during the first wave and four out of five (3.0, 4.6) during the second wave. Interpretation The experience of the COVID Symptom Study highlights the important role citizens can play in real-time monitoring of infectious diseases, and how app-based data collection may be used for data-driven rapid responses to public health challenges.
Acceptability and Satisfaction of Contraceptive Vaginal Rings in Clinical Studies: A Systematic Review and Narrative Synthesis

Introduction: Acceptability of and satisfaction with contraceptive methods are paramount for uptake and continuation. In the current context of multipurpose prevention of pregnancy and sexually transmitted diseases/HIV development, it is critical to have a better understanding of acceptability of and satisfaction with the contraceptive vaginal ring (CVR) including sexual satisfaction. The objective of this study was to review the evidence about acceptability of CVRs and general and sexual satisfaction of users. Methods: We searched PubMed, CINAHL, and Web of Science (until December 31, 2020) and selected original studies documenting actual use of hormonal CVR and explicitly addressing any of the 3 outcomes. Results: Of a total of 1,129 records screened, 46 studies were included. Most studies (n = 43, 93%) were prospective, conducted in high-income settings (n = 35), and reported on NuvaRing® use (n = 31). Overall, 27 (59%) studies included a comparison group, 38 (82%) studies used exclusively quantitative questionnaires, with qualitative only (n = 4, 9%), or mixed methods (n = 4, 9%) studies being less common. Ease of CVR insertion/removal/reinsertion was high in all the settings and improved with time of use, with qualitative studies supporting these findings. When mentioned, ring-related events were associated with discontinuation, and results on continuation of use were mixed. Among NuvaRing® studies, general satisfaction (being satisfied or very satisfied) was between 80 and 90% and tended to mirror continuation. Sexual satisfaction was less commonly reported and results were mixed. Overall, limited information was provided on actual CVR experiences of women (and men) and cultural norms that may affect sexuality and CVR use. Conclusion: Positive aspects of acceptability of and satisfaction with CVRs were reported, but ring-related events and factors, which may affect long-term CVR use, deserve further study. More information is needed on actual experiences of women using CVRs, relationship aspects, male partner opinions, and contextual norms to better understand the acceptability of and satisfaction with CVRs.
NSS_A_207764 123..130

Chinchuta Khumtong Nutta Taneepanichskul 1College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand; 2Faculty of Science and Technology, Valaya Alongkorn Rajabhat University, Phathum Thani, Thailand Background:Urban firefighters are at risk of posttraumatic stress disorder (PTSD) because of their occupational exposure to trauma events. Little is known, however, about the effects of exposure to trauma events on sleep quality among firefighters in Thailand. Purpose: The objective of this study was to find an assocaition between PTSD and sleep quality among firefighters. Methods: A cross-sectional study was conducted among active male firefighters in Bangkok. Participants completed the Posttraumatic Stress Disorder Checklist – Civilian Version (PCL-C-THAI) and the Pittsburgh Sleep Quality Index (PSQI-THAI) questionnaires. Multivariable logistic regression models were performed to estimate adjusted odds ratio (AOR) and 95% confidence intervals (95% CI). Results: A total of 1215 firefighters participated, of which 78 (6.4%) met the suggested PCL cut-point criteria for civilians (PCL-C scores >44). In addition, 596 (49.1%) had poor sleep quality (PSQI >5). PTSD firefighters had increased 6.49 fold odds of poorer sleep quality (AOR =6.49, 95% CI 3.13–13.44). Conclusion: Firefighters with PTSD had a significantly higher probability of experiencing poor sleep quality than those without. In response, a psychological health intervention may be needed to enhance the firefighters’ health.
Robust Mode Analysis

In this paper, we introduce a model-free algorithm, robust mode analysis (RMA), to extract primary constituents in a fluid or reacting flow directly from high-frequency, high-resolution experimental data. It is expected to be particularly useful in studying strongly driven flows, where nonlinearities can induce chaotic and irregular dynamics. The lack of precise governing equations and the absence of symmetries or other simplifying constraints in realistic configurations preclude the derivation of analytical solutions for these systems; the presence of flow structures over a wide range of scales handicaps finding their numerical solutions. Thus, the need for direct analysis of experimental data is reinforced. RMA is predicated on the assumption that primary flow constituents are common in multiple, nominally identical realizations of an experiment. Their search relies on the identification of common dynamic modes in the experiments, the commonality established via proximity of the eigenvalues and eigenfunctions. Robust flow constituents are then constructed by combining common dynamic modes that flow at the same rate. We illustrate RMA using reacting flows behind a symmetric bluff body. Two robust constituents, whose signatures resemble symmetric and von Karman vortex shedding, are identified. It is shown how RMA can be implemented via extended dynamic mode decomposition in flow configurations interrogated with a small number of time-series. This approach may prove useful in analyzing changes in flow patterns in engines and propulsion systems equipped with sturdy arrays of pressure transducers or thermocouples. Finally, an analysis of high Reynolds number jet flows suggests that tests of statistical characterizations in turbulent flows may best be done using non-robust components of the flow.
Early Nutritional Education in the Prevention of Childhood Obesity

Early childhood is a critical period for obesity prevention. This randomized controlled study evaluated the effectiveness of an educational intervention preventing obesity in preschool-age children. A nutritional education intervention, with a follow-up session one year later, was conducted with parents of children aged 3 to 4 years of public schools in the province of Málaga. The main outcome variable was the body mass index z-score (zBMI). The prevalence of overweight or obesity was the secondary outcome variable. The sample comprised 261 students (control group = 139). Initial BMI, weight, height-for-age and prevalence of overweight and obesity were similar for both groups. After the first year of the intervention, the zBMI of the intervention group decreased significantly from 0.23 to 0.10 (p = 0.002), and the subgroup of patients with baseline zBMI above the median decreased from 1 to 0.72 (p = 0.001), and in the second year from 1.01 to 0.73 (p = 0.002). The joint prevalence of overweight and obesity increased in the control group (12.2% to 20.1%; p = 0.027), while in the intervention group, there were no significant changes. This preschool educational intervention with parents improved their children’s BMI, especially those with a higher BMI for their age, and favored the prevention of overweight or obesity.
An Unprecedented Straightforward Synthesis of Chiral Pyrrolo[3,4-b]quinolone and Pyrrolo[3,2-b]quinolone Backbones Starting from trans-4-Hydroxy-L-proline

The straightforward synthesis of pyrrolo[3,4-b]quinolone and pyrrolo[3,2-b]quinolone backbones, which can be found in molecules exhibiting anticancer activities, is presented. The key step of the process is an efficient and unprecedented Friedlander condensation between an oxoproline carbamate, obtained in 3 steps and good yield starting from commercially available and relatively cheap trans-4-hydroxy-L-proline, and various 2-amino-substituted carbonyl derivatives. It was demonstrated that the formation of the two possible regioisomers was fully triggered by both the R substituent onto the 2-amino-substituted carbonyl compounds and the ester function onto the oxoproline carbamate. Thus, in some cases, a complete regiocontrol for the Friedlander reaction could be attained.
Do Heavy Vehicles Always Have a Negative Effect on Traffic Flow?

The purpose of this study is to analyze the effect of heavy vehicles on traffic flow on a twolane highway. To achieve this goal, data was obtained from piezosensors on the Seoul–Chuncheon Expressway. Analysis of the data showed that, as everyone knows, the average speed of traffic flows decreases as the proportion of heavy vehicles increases. However, not only the speed decreased, but the speed deviation between vehicles decreased. In other words, it was found that within the traffic group that formed the same platoon, individual vehicles were forced to form similar speeds, resulting in a homogeneous rate. This means that heavy vehicles can be included in the traffic stream, reducing the chances of a vehicle-to-vehicle conflict. This kind of influence can be said to explain that heavy vehicles do not necessarily have a negative effect on traffic flow. In this way, we expect to be able to study ways to manage traffic flow by using the effects of low-speed vehicles.
DATA HIDING METHOD DESIGN IN JPEG IMAGE COMPRESSION WITH MODIFIED MODULO AND ELEMENT SELECTION

: This paper presents a new Steganography technique, In this paper, we propose a new high-capacity reversible data hiding method for JPEG-compressed images. This method is based on modifying the quantization table and quantized discrete cosine transformation (DCT) coefficients. Some elements of the quantization table are divided by an integer while the corresponding quantized DCT coefficients are multiplied by the same integer and added by an adjustment value to make space for embedding the data. By analyzing the effect of each single quantized DCT coefficient on the image quality, an embedding sequence is chosen in order to help control the increase of file size after hiding the data meanwhile the PSNR value between the original uncompressed image and stego JPEG image is high. Experimental results show that the proposed method achieves both high capacity and high image quality.
Agronomic and physiological behavior of maize native to southeastern Mexico

Mexico is the center of origin and domestication of maize (Zea mays L.), in some regions there are still creole populations with the potential to generate improved varieties. The objective of this study was to evaluate the agronomic and physiological behavior of twelve maize populations native to southeastern Mexico. The experiment was carried out in Tizimín, Yucatán in 2017. 32 parameters corresponding to vegetative, phenological, agronomic and physiological variables were evaluated. The results showed a difference of 75 cm between the lower plants (Xn-69) and those of higher bearing (CNB), the plants of the population DZ-252 presented greater foliage (19.1 leaves) and greater stem diameter (26 mm), the earliest populations were CM and CCB (65.5 and 65.8 days, respectively). 58% of the populations evaluated exceeded the average yield of the region (4.5 t ha). The highest yield was obtained by the CM, Cro, H1 and SP2015 populations (117.7, 105.8, 111.5 and 109.5 g plant, respectively). The populations CM, DZ2015, Cja and Cro had a higher photosynthetic rate; however, the highest water use efficiency was presented by the DZ-252 and XnQroo populations (8.9 μmol CO2/mmol H2O). The CM population stood out for its performance and precocity, the DZ-252 could be used as fodder for the amount of biomass it generated and the XnQroo should be studied under conditions of water restriction for its efficiency of water use, these three populations should be included in breeding programs
MULTILINEAR CALDERÓN-ZYGMUND OPERATORS AND THEIR COMMUTATORS ON CENTRAL MORREY SPACES WITH VARIABLE EXPONENT

In this paper, we establish the boundedness of the m-linear Calderón-Zygmund operators on product of central Morrey spaces with variable exponent. The corresponding boundedness properties of their commutators with λ-central BMO symbols are also considered. Finally, we prove that the multilinear commutators of Calderón-Zygmund singular integrals introduced by Pérez and Trujillo-González are bounded on central Morrey spaces with variable exponent. Our results improve and generalize some previous classical results to the variable exponent setting.
A Merging Method to Discretizing and Grouping the Input Factors of ANOVA Model while Research of Time Dynamic of the Students Intelligence Quotient

In present work we study, with use of multivariate ANOVA model, the influence of independent factors such as year, faculty, gender, on the indicators of students' general intelligence (IQ) with a sample collected in 1991-2013 at the Novosibirsk State Technical University. The peculiarity of models of this type is that the response is a quantitative variable, and the input features must be qualitative. Therefore, first, the problem of converting quantitative features into categorical ones (discretization) arises, second, with a large number of levels of input qualitative features their grouping is required. If the variables are strongly correlated, then both tasks should be solved simultaneously. In this case, the optimal quality of the model should be ensured in accordance with a certain criterion. Existing methods for the features type conversion are limited to one of the tasks (discretization or grouping) and often do not take into account the relationships between the features. Therefore, an original approach is proposed that allows solving the problem and interpreting the results obtained.