Miracle-dz/UniFAR-FTUs huggingface dataset:
Association Between Visual Memory and In Vivo Amyloid and Tau Pathology in Preclinical Autosomal Dominant Alzheimer’s Disease

Abstract Objective: Visual memory (ViM) declines early in Alzheimer’s disease (AD). However, it is unclear whether ViM impairment is evident in the preclinical stage and relates to markers of AD pathology. We examined the relationship between ViM performance and in vivo markers of brain pathology in individuals with autosomal dominant AD (ADAD). Methods: Forty-five cognitively unimpaired individuals from a Colombian kindred with the Presenilin 1 (PSEN1) E280A ADAD mutation (19 carriers and 26 noncarriers) completed the Rey–Osterrieth Complex Figure immediate recall test, a measure of ViM. Cortical amyloid burden and regional tau deposition in the entorhinal cortex (EC) and inferior temporal cortex (IT) were measured using 11C-Pittsburgh compound B positron emission tomography (PET) and 11F-flortaucipir PET, respectively. Results: Cognitively unimpaired carriers and noncarriers did not differ on ViM performance. Compared to noncarriers, carriers had higher levels of cortical amyloid and regional tau in both the EC and IT. In cognitively unimpaired carriers, greater cortical amyloid burden, higher levels of regional tau, and greater age were associated with worse ViM performance. Only a moderate correlation between regional tau and ViM performance remained after adjusting for verbal memory scores. None of these correlations were observed in noncarriers. Conclusions: Results suggest that AD pathology and greater age are associated with worse ViM performance in ADAD before the onset of clinical symptoms. Further investigation with larger samples and longitudinal follow-up is needed to examine the utility of ViM measures for identifying individuals at high risk of developing dementia later in life.
Dimensioning of Large-Scale Hybrid Optoelectronic Networks with Modular Switch Costs and Grooming

We examine in this paper the problem of dimensioning large hybrid optoelectronic networks with grooming when switch costs are highly modular. Using a new heuristic, we ar e now able to investigate networks of a size much larger than wh at was previously possible. We show that the impact of grooming and modular switch costs on the design process is very signifi cant for large networks as well. Increasing the number of alternate paths decreases the network cost while increasing the path l ength increases it. We also show that the modular switch costs prod uce solutions where the switches are nearly always fully utiliz ed. Finally, we also show that the relative size of the demands of fered to the network can have a significant effect on the cost, a feat ure that cannot be captured by other models.
Word Dose in the Disruption of Serial Recall by Irrelevant Speech: Phonological Confusions or Changing State?

Irrelevant background speech disrupts serial recall of visually presented lists of verbal material. Three experiments tested the hypothesis that the degree of disruption is dependent on the number of words heard (i.e. word dose) whilst the task was undertaken. Experiments 1 and 2 showed that more disruption is produced if the word dose is increased, thereby providing evidence to support the experimental hypothesis. It was concluded from the first two experiments that the word-dose effect might be the result of increasing the amount of changing-state information in the speech. The results of Experiment 3 supported this conclusion by showing an interaction between word dose and changing-state information. It was noted however that the results might be explained within the working memory account of the disruptive action of irrelevant speech. A further two experiments cast doubt on this possibility by failing to replicate the finding that the phonological similarity between heard and seen material affects the degree of interference (Salamé & Baddeley, 1982). The findings are discussed in relation to the changing state hypothesis of the irrelevant speech effect (e.g. Jones, Madden, & Miles, 1992).
Making sense of industrial networks via discourse analysis: the performative effect of theories and language

The purpose of our paper is to ‘open the IMP network’ to alternative methods in order to contribute to a better understanding of business markets. We draw upon hermeneutic approaches from the fields of discursive social psychology and social linguistics, underpinned by a social constructionist worldview of language. Such approaches are taken in order to illuminate the ‘sense-making’ processes of individual network actors. In taking the ‘linguistic turn’, however, this paper does not diminish the contribution of the IMP literature; rather it sets out to augment it through a discourse analytic approach. The methodology of discourse analysis is useful to marketing researchers since it can liberate the non-rational and subjective ways in which networks are constructed by their participants. It allows us to examine processes of network legitimation and negotiations over meaning. Moreover, in addressing linguistic and social issues by linking text and context, it asks how and why such negotiations are attempted. For instance, in exploring the concept of intertextuality, it can show how theories can have a potentially performative effect. In such recursive interaction, the concept of ‘repertoires’ can allow for both agency and constraint on the part of participants. Our paper draws upon data gathered from interviews with managerial participants in both UK and Australasian contexts, the former involving a series of ‘traditional’ supply chains including agriculture and textiles, and the latter comprising industrial buyers and suppliers in an ‘e-marketplace’. Key findings that emerge from our analysis include several ‘families’ of repertoires drawn on by network participants to make sense of trust building in inter-firm relationships. The commonality of the patterns of occurrence of these repertoires across the contrasting cultural and trading contexts faced/created by participants is striking, even in the construction of ‘trustworthiness’. Also of interest are the discursive tensions found in the co-existence of contrasting repertoires within the same stretches of talk, suggesting that institutional network processes are replete with paradoxes. Our main contribution is to show how managers’ talk ‘about’ management illustrates the intertextual recursive relationship between the discourses of participants and theories such as those of ‘relationship marketing’. These ‘textbook’ theories appear to inform actors’ ‘network theories’ and help to generate the atmosphere of the relationships into which participants act. By highlighting some of the textual connections between everyday discourse, social structures and a variety of ‘macro’ repertoires of industrial networks, we argue that DA holds considerable promise for both researchers and practitioners in re-interpreting such paradoxical contexts.
The Influence of Organizational Change (Bank Merger) on Employee's Attitude Response

This research aims to examine the influence of organizational change (bank merger) on employee’s attitude response. The research design is expost facto. The population involved in the research comprises bank employees working before and after the bank was merged. The population consists of 100 people and the sampling is done in census. Data was taken from respondents through questionnaires and analyzed using PLS 1.8. The findings of the research show that bank merger affects employees’ attitude response positively and significantly. If bank merger is judged positively by bank employees, bank merger is able to establish a positive influence for employees’ response. Keywords— organizational change, merger, attitude response
Nutrient – Gene Interactions Epicatechin and a Cocoa Polyphenolic Extract Modulate Gene Expression in Human Caco-2 Cells 1

We performed a functional genomic analysis to study the effect of epicatechin and polyphenolic cocoa extract in the human colon adenocarcinoma cell line Caco-2. The specific Human Hematology/Immunology cDNA arrays by Clontech, containing 406 genes in duplicate, were used. The differentially expressed genes were classified according to their level of expression, calculated as the ratio of the value obtained after each treatment relative to control cells, with a statistical significance of P 0.05 (upregulated: ratio 1.5; downregulated: ratio 0.6). Treatment with epicatechin decreased the expression of 21 genes and upregulated 24 genes. Upon incubation with the cocoa polyphenolic extract, 24 genes were underexpressed and 28 were overexpressed. The changes in expression for ferritin heavy polypeptide 1 (FTH1), mitogen-activated protein kinase kinase 1 (MAPKK1), signal transducer and activator of transcription 1 (STAT1), and topoisomerase 1 upon incubation with epicatechin, and for myeloid leukemia factor 2 (MLF2), CCAAT/enhancer binding protein gamma (C/EBPG), MAPKK1, ATPbinding cassette, subfamily c member 1 (MRP1), STAT1, topoisomerase 1, and x-ray repair complementing defective repair 1 (XRCC1) upon incubation with the cocoa polyphenolic extract were validated by RT-PCR. Changes in the messenger RNA levels for MAPKK1, STAT1, MRP1, and topoisomerase 1 upon incubation with either epicatechin or cocoa extract were further confirmed at the protein level by Western blotting. The changes in the expression of STAT1, MAPKK1, MRP1, and FTH1 genes, which are involved in the cellular response to oxidative stress, are in agreement with the antioxidant properties of cocoa flavonoids. In addition, the changes in the expression of C/EBPG, topoisomerase 1, MLF2, and XRCC1 suggest novel mechanisms of action of flavonoids at the molecular level. J. Nutr. 134: 2509–2516, 2004.
Intergenerational Transmission and Support for EU Membership in the United Kingdom: The Case of Brexit

Euroscepticism is increasingly important to the shaping and understanding of contemporary European public opinion and politics. The origins of the trait, however, particularly the values that predispose individuals to view the European Union (EU) as a legitimate (or otherwise) political institution, remain poorly understood. Literature on political socialization identifies the family as a vital influence on the development of many social and political attitudes. This study explores the role of the family in the development of Euroscepticism by examining evidence of intergenerational transmission of hostility towards membership of the EU between parents and children in the United Kingdom during its ‘Brexit referendum’. The study shows that the attitudes of parents during one’s politically formative years can be an important factor in shaping support for EU membership. It also finds that this intergenerational transmission is different for mothers and fathers: while there is a greater likelihood of a child’s attitudes being affected by those of their father, if they are affected by their mother’s views they are more likely to eventually share their mother’s position on EU membership. This identifies the family as a key source of the values that shape support for European integration, potentially accelerating or opposing other social trends that have resulted in successive generations typically being more supportive of EU membership.
Trust no one? Citizens' concerns regarding the pork and dairy supply chain

Latest studies show that a responsible treatment of farm animals is important to many citizens. Furthermore, societal expectations towards animal husbandry and present husbandry systems mismatch more and more. Thereby, pig production is criticized more than dairy farming. This paper gives insights into citizens’ main points of criticism among the pork and dairy cattle supply chain. It also intends to show several aspects of distrust. To capture a variety of opinions and expectations among the population, focus groups with citizens were carried out. For each topic (pig and dairy cattle husbandry) six focus groups took place in three German cities. Participants discussed about their perception of actual animal husbandry with respect to housing systems, animal health and well-being. Using content analysis with a mixed inductive and deductive category system, three sources of concerns were identified: role of farmers, legal framework and food retail. First, participants reflect the role of farmers and discuss that farmers only comply with the minimum of statutory requirements. Accordingly, participants think that farmers accept fines in order to avoid changes in their animal husbandry. Second, participants doubt the legal framework. In their view the standards are very low, especially regarding animal welfare. So, for instance, it enables farmers to circumvent the regulations. To improve the situation, participants emphasize a major revision of the legal framework for animal husbandry. Another critical focus is on legal controls. Participants remark that controls are often announced previously. The third point of criticism affects food retail. It is complicated for consumers to understand the complete supply chain. According to this, animal production takes more and more place behind closed doors without transparency. Altogether these aspects lead to an increasing rejection of animal products. The concerns were stronger in case of pork than in case of dairy cattle. As a consequence, some participants state to consume less or no pork or change to meat alternatives. Results suggest different possibilities among the complete supply chain, to understand citizens’ points of concerns better and to improve the situation of farm animal husbandry. Doing so, citizens’ concerns might be reduced resulting in more trust into the whole system again. Hence, more consumers of meat will be kept and will not consume more and more meat substitutes.
Land Use Scenario Modeling Based on Local Knowledge for the Provision of Ecosystem Services in Northern Ghana

The understanding of multiple effects by possible future development is essential for adapted land use planning. This study assessed the potential of land use scenarios for the provision of ecosystem services using local knowledge in two districts of northern Ghana. Local knowledge was gathered through surveys with extension officers, who are regarded as eligible knowledge holders for agricultural land use. Firstly, ecosystem services that were perceived as important by the stakeholders were identified, namely food, fodder, energy, construction materials, marketable products, water provision, and erosion control. Quantitative indicators were then determined to analyze the capacity of land use types to supply the ecosystem services. Land use scenarios were developed based on their applicability and capacity to mitigate climate change impacts. The perception of stakeholders was applied to evaluate changes in ecosystem services provision by the scenarios. A modeling approach for a spatially explicit simulation was used to assess the potential to provide ecosystem services at a district level. The results reflected the different trade-offs and synergies between ecosystem services of each scenario, depending on the district. Along with the local perception, characteristics of land use patterns also influenced the regional potential of ecosystem services provision.
Optimal Preview Control for Linear Discrete-Time Periodic Systems

In this paper, the optimal preview tracking control problem for a class of linear discrete-time periodic systems is investigated and the method to design the optimal preview controller for such systems is given. Initially, by fully considering the characteristic that the coefficient matrices are periodic functions, the system can be converted into a time-invariant system through lifting method. Then, the original problem is also transformed into the scenario of time-invariant system. Later on, the augmented system is constructed and the preview controller of the original system is obtained with the help of existing preview control method. The controller comprises integrator, state feedback, and preview feedforward. Finally, the simulation example shows the effectiveness of the proposed preview controller in improving the tracking performance of the close-loop system.
Association of Serum Calcium and Phosphate Concentrations with Glucose Metabolism Markers: The Furukawa Nutrition and Health Study

Calcium and phosphate may play an important role in cardio-metabolic abnormalities, including type 2 diabetes; however, epidemiological evidence of the association of calcium and phosphate status with glucose metabolism among Asians is limited. In the current study, we performed a cross-sectional analysis of the association of serum calcium, phosphate, and calcium–phosphate product concentrations with glucose metabolism markers among Japanese individuals. Overall, 1701 workers (aged 18–78 years) who participated in a health survey were enrolled in this study. Multivariable linear regression models were used to estimate means of homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of β-cell function (HOMA-β), and glycated hemoglobin (HbA1c). Serum calcium concentration was positively associated with HOMA-IR and HbA1c (p for trend < 0.01). Multivariable-adjusted means (95% confidence interval (CI)) of HOMA-IR for the lowest and highest quartiles of serum calcium were 0.78 (0.75–0.82) and 1.01 (0.96–1.07), respectively. The corresponding values for HbA1c were 5.24 (5.22–5.27) and 5.29 (5.26–5.32), respectively. Serum phosphate and calcium–phosphate product concentrations were inversely associated with HOMA-IR (p for trend < 0.01). Multivariable-adjusted means (95% CI) of HOMA-IR for the lowest and highest quartiles of serum phosphate were 1.04 (0.99–1.09) and 0.72 (0.69–0.76), respectively. The corresponding values for calcium–phosphate product were 1.04 (0.99–1.09) and 0.73 (0.69–0.77), respectively. The current findings suggest that higher serum calcium and lower serum phosphate concentrations are associated with IR among apparently healthy adults.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways

Abstract Cervical cancer (CC) is a common gynecological malignancy and represents a major global health challenge. Chemotherapeutic agents are commonly applied in treatment of CC, while along various adverse effects and chemotherapy resistance. As an iridoid glycoside compound, gentiopicroside (GPS) possesses the characteristic of the better availability and lower toxicity effect on cancer treatment. In the present study, we investigated that GPS exhibited the anticancer effect on HeLa cells through the inhibition of cell growth, induced apoptosis, cycle arrest, and suppressed migration. Furthermore, the possible mechanism or the targets of GPS was also clarified. The results revealed that GPS exerted an anti-proliferation effect in a dose- and time-dependent manner in HeLa cells, in contrast, with the less inhibiting proliferation effects on normal cell line (HUVEC). Moreover, GPS arrested cells at G2/M phase and induced apoptosis through mitochondrial apoptotic pathway. More significantly, GPS dramatically inhibited the migration of HeLa cells and regulated the matrix metalloproteinase expression through the MAPK and Akt signaling pathways, of which MAPK1 was an underlying target in GPS against HeLa cells.
Sarcopenia and inflammation in patients undergoing hemodialysis.

INTRODUCTION in individuals with chronic kidney disease, sarcopenia is prevalent and is associated with increased morbidity and mortality, and the occurrence of cardiovascular complications. OBJECTIVE to verify the relationship between sarcopenia and inflammation in hemodialysis patients. METHODS a cross-sectional study with 209 patients in five hemodialysis units. Demographic, socioeconomic, body composition, clinical laboratory, and functional data were collected. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People (grip strength < 27 kg for men and < 16 kg for women; DEXA muscle mass < 7.0 kg/m² for men and < 5.5 kg/m² for women). Inflammation was assessed by C-reactive protein. RESULTS mean age was 51.9 ± 15.0 years, with a predominance of males (59.3 %). The prevalence of sarcopenia was 29.1 % and that of inflammation was 50.2 %. A Poisson regression analysis showed that sarcopenia was associated with increased hsCRP values (PR: 1.06; 95 % CI: 1.01-1.10; p-value = 0.005); BMI (PR: 0.74; 95 % CI: 0.65-0.84; p-value < 0.001); age (PR: 1.02; 95 % CI: 1.00-1.03; p < 0.001); male (PR: 5.75; 95 % CI: 3.20-10.34; p-value < 0.001); presence of DM (PR: 1.87; 95 % CI: 1.27-2.74; p-value < 0.001); % body fat (PR: 1.07; 95 % CI: 1.04-1.09; p-value < 0.001). CONCLUSION the prevalence of sarcopenia can be considered high in this study, as well as inflammation. Being inflamed, presence of DM, being male, increasing age, and % body fat were risk factors for sarcopenia. On the other hand, increased BMI had a protective role.
Increased Risk of Acquisition of New Delhi Metallo-Beta-Lactamase-Producing Carbapenem-Resistant Enterobacterales (NDM-CRE) among a Cohort of COVID-19 Patients in a Teaching Hospital in Tuscany, Italy

We describe the epidemiology of New Delhi Metallo-Beta-Lactamase-Producing Carbapenem-Resistant Enterobacterales (NDM-CRE) colonization/infection in a cohort of COVID-19 patients in an Italian teaching hospital. These patients had an increased risk of NDM-CRE acquisition versus the usual patients (75.9 vs. 25.3 cases/10,000 patient days). The co-infection significantly increased the duration of hospital stay (32.9 vs. 15.8 days).
Allelopathic effects of native and invasive Brassica nigra do not support the novel-weapons hypothesis.

PREMISE The novel-weapons hypothesis predicts that some plants are successful invaders because they release allelopathic compounds that are highly suppressive to naïve competitors in invaded ranges but are relatively ineffective against competitors in the native range. For its part, the evolution of enhanced weaponry hypothesis predicts that invasive populations may evolve increased expression of the allelopathic compounds. However, these predictions have rarely been tested empirically. METHODS Here, we made aqueous extracts of roots and shoots of invasive (North American) and native (European) Brassica nigra plants. Seeds of nine species from North America and nine species from Europe were exposed to these extracts. As control solutions, we used pure distilled water and distilled water with the osmotic potential adjusted with polyethylene glycol (PEG) to match that of root and shoot extracts of B. nigra. RESULTS The extracts had a strong negative effect on germination rates and seedling root lengths of target species compared to the water-control. Compared to the osmolality-adjusted controls, the extracts had a negative effect on seedling root length. We found no differences between the effects of B. nigra plant extracts from the invasive vs. native populations on germination rates and seedling root growth of target plant species. Responses were largely independent of whether the target plant species were from the invaded or native range of B. nigra. CONCLUSIONS The results show that B. nigra can interfere with other species through allelochemical interactions, but do not support predictions of the novel-weapons hypothesis and evolution of increased allelopathy.