Miracle-dz/UniFAR-FTUs huggingface dataset:
Spatial analysis of Fire Characterization along with various gradients of Season, Administrative units, Vegetation, Socio economy, Topography and Future climate change: A case study of Orissa state of India

Fire events are an increasing phenomenon these days due to the climate change. It is responsible for forest degradation and habitat destruction. Changes in ecosystem processes are also noticed. The livelihood of tribal population is also threatened. Geospatial technologies along with Remotely Sensed data have enormous capability to evaluate the various diversified datasets and to examine their relationship. In this analysis, we have utilized the long term fire events at district level for the Orissa state ofIndiaand forest fire hotspots were identified. The fire pattern was analyzed with respect to the existing vegetation types, tribal population and topography to understand its association/relationship. Furthermore, it was evaluated with future climate change data for better comprehension of future forest fire scenario. The study reveals that Kandhamal, Raygada and Kalahandi district have highest fire frequency representing around 38% of the total Orissa fire events. The vegetation type “Tropical mixed deciduous and dry deciduous forests” and “Tropical lowland forests, broadleaved, evergreen, <1000m” occupy the geographical area roughly 43% whereas they retain fire percent equivalent to 70%. Approximately 70% of forest fire occurred in the area where tribal population was high to very high. The 60% of forest fire occurred where elevation was greater than500 meterswhereas 48% of fire occurred on moderate slopes. Our observation of future climate change scenario for the year 2030 reflects the increase in summer temperature and irregular rainfall pattern. Therefore, forest fire intensity will be more in future in the state of Orissa whereas it’s intensity will be more severe in few of the district such as Kandhamal, Raygada, Kalahandi and Koraput which have significantly high forest fire events in present scenario. The outcomes of the present study would certainly guide the policymakers to prepare more effective plan to protect the forest which is main source of livelihood to the tribal population keeping in mind of future climate change impact for prioritization of various districts of state of Orissa suffering from forest fires.
Success factors of transformative learning: putting theory into practice

ABSTRACT This paper elaborates on a number of key success factors of transformative learning (TL) theory as well as provides arguments that validate them. The paper at hands lines out how transformative learning can improve teams in start-ups and NGOs to the direction of education for sustainable development (ESD). Moreover, social structures and belief systems can influence learning in a way that learners make transformation of their experiences in various means. It exemplifies how Mezirow’s theory can be put into practice and includes results from collaborative and social learning, personal transformation, team spirit as well as learning environments. The case studies make use of new skills and values via guided interviews. Data from 42 qualitative interviews are analysed and used to argument that transformative learning can be practiced, with success factors, in start-ups and NGOs.
Morphological and Physiological Framework Underlying Plant Longevity in Arabidopsis thaliana

Monocarpic plants have a single reproductive phase, in which their longevity is developmentally programmed by molecular networks. In the reproductive phase of Arabidopsis thaliana, the inflorescence meristem (IM) maintains a central pool of stem cells and produces a limited number of flower primordia, which result in seed formation and the death of the whole plant. In this study, we observed morphological changes in the IM at cellular and intracellular resolutions until the end of the plant life cycle. We observed four biological events during the periods from 1 week after bolting (WAB) till the death of stem cells: (1) the gradual reduction in the size of the IM, (2) the dynamic vacuolation of IM cells, (3) the loss of the expression of the stem cell determinant WUSCHEL (WUS), and (4) the upregulation of the programmed cell death marker BIFUNCTIONAL NUCLEASE1 (BFN1) in association with the death of stem cells. These results indicate that the stem cell population gradually decreases in IM during plant aging and eventually is fully terminated. We further show that the expression of WUS became undetectable in IM at 3 WAB prior to the loss of CLAVATA3 (CLV3) expression at 5 WAB; CLV3 is a negative regulator of WUS. Moreover, clv3 plants showed delayed loss of WUS and lived 6 weeks longer compared with wild-type plants. These results indicated that the prolonged expression of CLV3 at 4–5 WAB may be a safeguard that inhibits the reactivation of WUS and promotes plant death. Finally, through transcriptome analysis, we determined that reactive oxygen species (ROS) are involved in the control of plant longevity. Our work presents a morphological and physiological framework for the regulation of plant longevity in Arabidopsis.
Ligation of the Maxillary Artery Prior to Caudal Maxillectomy in the Dog—A Description of the Technique, Retrospective Evaluation of Blood Loss, and Cadaveric Evaluation of Maxillary Artery Anatomy

Two different surgical techniques have been described for performing caudal maxillectomies in dogs including the intraoral (IO) and combined dorsolateral and intraoral (DL-IO) approach. Hemorrhage is the most common intraoperative complication reported during these procedures as maxillary arterial ligation is not performed until after all osteotomies and mobilization of tumor-bearing bone. The objectives of this study were to describe a modified approach for caudal maxillectomy in the dog involving preligation of the maxillary artery, to retrospectively evaluate the ability of this modified approach to limit hemorrhage in a cohort of 22 dogs, and to clarify the vascular anatomy of the maxillary artery and its branches in relation to associated nerves. Medical records were retrospectively reviewed for cases that had caudal maxillectomy via a combined approach (with or without preligation of the maxillary artery) from January 1, 2004 to December 31, 2019. Twenty-two cases were identified, six without, and 16 with arterial preligation, respectively. Osteotomies were completed with a high-speed handpiece and rotary bur (n = 18), or oscillating bone saw (n = 4). All six (100%) dogs in the traditional DL-IO group developed hypotension under general anesthesia. Four (67%) of these required intraoperative blood transfusions, one of which required an additional postoperative blood transfusion. In contrast, only one of 16 (6%) dogs in the modified DL-IO group required an intraoperative blood transfusion, and only three (19%) developed hypotension. Moreover, a significant association was detected between postoperative PCV and the two different surgical approaches (P = 0.021). These results demonstrate the effectiveness of preligation of the maxillary artery in preventing hemorrhage in caudal maxillectomies in dogs and this represents an improvement in outcome over previously reported studies. Decreased intraoperative hemorrhage may improve surgical exposure and decrease overall patient morbidity.
Exploring the Thermal Signature of Guilt, Shame, and Remorse

The recent study of complex emotions using visual storyboards by Bhushan et al. (2020) endorses that same scenario can induce guilt/remorse or guilt/shame in people based on valence. These findings were based on behavioral data and did not consider body physiology. The present study aimed to explore the difference in the thermal signature of scenarios that elicit guilt in some and shame/remorse in others. Using storyboard depicting 13 scenarios, we analyzed the thermal changes on the forehead, eyes (left and right separately), cheek (left and right separately), nose tip, and mouth regions of the face with the objective of exploring the thermal signature of guilt, shame, and remorse. Data were collected from 31 participants using a thermal camera in a laboratory setting. We found a difference of 0.5°C or above change in temperature on the forehead, left and right cheeks, and mouth regions during guilt experience compared to shame and remorse experiences. The temperature of the right and left cheeks was high for guilt as compared to remorse for two scenarios inducing guilt/remorse, and the difference was statistically significant. For one of the scenarios inducing guilt/shame, thermal change in the right eye region was higher for shame as compared to guilt. The findings are discussed in light of the distribution of blood vessels on the face.
Trophic Structure and Sources of Variation Influencing the Stable Isotope Signatures of Meso- and Bathypelagic Micronekton Fishes

To better understand spatiotemporal variation in the trophic structure of deep-pelagic species, we examined the isotope values of particulate organic matter (POM) (isotopic baseline) and seven deep-pelagic fishes with similar diet compositions but contrasting vertical distributions across mesoscale features in the Gulf of Mexico using stable isotope and amino acid compound-specific isotope analyses. Species examined included four migratory (Benthosema suborbitale, Lepidophanes guentheri, Melamphaes simus, Sigmops elongatus) and three non-migratory zooplanktivorous fishes (Argyropelecus hemigymnus, Cyclothone obscura, Sternoptyx pseudobscura). Isotopic values of POM increased with depth, with meso- and bathypelagic samples characterized by higher δ13C and δ15N values relative to epipelagic samples. Despite similar diet compositions, mean δ15N values of fishes spanned 3.43‰ resulting in mean trophic position estimates among species varying by 1.09 trophic levels. Interspecific differences in δ15N were driven by higher δ15N values in the non-migratory and deepest dwelling C. obscura (10.61‰) and lower δ15N values in the migratory and shallowest dwelling L. guentheri (7.18‰) and B. suborbitale (8.11‰). Similarly, fish δ15NsourceAA values were correlated with depth, with the lowest values occurring in the migratory L. guentheri and B. suborbitale and highest values occurring in the non-migratory C. obscura. Our data suggest that depth-related trends in fish δ15N and δ15NsourceAA values are driven by shallower dwelling species feeding within epipelagic food webs supported by POM with lower δ15N values, while deeper dwelling, non-migratory species increasingly use food webs at depth supported by POM with elevated δ15N values. Horizontal isotopic variation was observed across a large mesoscale oceanographic feature (Loop Current), with POM, three migratory, and one non-migratory species characterized by higher δ13C and lower δ15N values in the anticyclonic Loop Current relative to surrounding water masses. Our results demonstrate that isotopic values of POM can vary significantly over relatively small horizontal and vertical scales and that baseline variation can be conserved in the signatures of higher-order consumers. By gaining a more thorough understanding of the sources contributing to isotopic variation of deep-pelagic fishes, this paper will inform the design and interpretation of future feeding studies in the pelagic realm and advances our knowledge of deep-pelagic food web structure.
The Opioid/Overdose Crisis as a Dialectics of Pain, Despair, and One-Sided Struggle

The opioid/overdose crisis in the United States and Canada has claimed hundreds of thousands of lives and has become a major field for research and interventions. It has embroiled pharmaceutical companies in lawsuits and possible bankruptcy filings. Effective interventions and policies toward this and future drug-related outbreaks may be improved by understanding the sociostructural roots of this outbreak. Much of the literature on roots of the opioid/overdose outbreak focuses on (1) the actions of pharmaceutical companies in inappropriately promoting the use of prescription opioids; (2) “deaths of despair” based on the deindustrialization of much of rural and urban Canada and the United States, and on the related marginalization and demoralization of those facing lifetimes of joblessness or precarious employment in poorly paid, often dangerous work; and (3) increase in occupationally-induced pain and injuries in the population. All three of these roots of the crisis—pharmaceutical misconduct and unethical marketing practices, despair based on deindustrialization and increased occupational pain—can be traced back, in part, to what has been called the “one-sided class war” that became prominent in the 1970s, became institutionalized as neo-liberalism in and since the 1980s, and may now be beginning to be challenged. We describe this one-sided class war, and how processes it sparked enabled pharmaceutical corporations in their misconduct, nurtured individualistic ideologies that fed into despair and drug use, weakened institutions that created social support in communities, and reduced barriers against injuries and other occupational pain at workplaces by reducing unionization, weakening surviving unions, and weakening the enforcement of rules about workplace safety and health. We then briefly discuss the implications of this analysis for programs and policies to mitigate or reverse the opioid/overdose outbreak.
Clinical Characteristics of Patients Seeking Treatment for Common Mental Disorders Presenting With Workplace Bullying Experiences

Background Targets of workplace bullying tend to develop severe mental health complaints, having increased risk of sick leave and expulsion from the workplace. Hence, these individuals are likely to be overrepresented among patients seeking treatment for common mental disorders (CMD). This study investigated the prevalence of exposure to workplace bullying in a patient group seeking treatment for CMD. Further we explored if exposed and non-exposed patients differed on clinical and work-related characteristics. Methods The sample comprised of 675 patients from an outpatient clinic in Norway and consisted of 70% women and had a mean age of 39 (SD = 10.5) years. The study had a cross-sectional design and differences between the patient groups were analysed using chi-square, Mann–Whitney U-tests and independent sample t-tests. Results The prevalence of exposure to bullying was 25.8%. The patients exposed to bullying reported significantly more major depressive disorders (MDDs) measured with the MINI psychiatric interview, higher levels of depressive symptoms, anxiety symptoms, subjective health complaints, alcohol use, and lower resilience as measured with questionnaires. Twice as many were on full-time sick leave, reported lower work ability, lower return to work self-efficacy, and lower job satisfaction. A majority preferred another job than the one they have today over returning to their current employment. Conclusion Victims of workplace bullying are a vulnerable group at risk of expulsion from working life, being overrepresented among patients seeking mental health treatment for CMD. One in four patients represented with such experience have higher levels of psychological symptoms and are more often diagnosed with depression as compared to other patients. Thus, this is a problem that should be addressed in clinical settings. If not addressed there is an increased risk of sick leave and permanent exclusion from working life.
Accountable Data Analytics Start with Accountable Data: The LiQuID Metadata Model

Insights based on data are omnipresent. However, in particular in modern data analytics applications, information about the underlying data often remain obscure, hindering accountable data analytics. Recent eﬀorts have been put into better describing such data based on metadata, similarly to what has been done in various scientiﬁc disciplines for transparent and reproducible research. Based on a detailed study of various metadata standards and proposals, we observe that existing metadata models do not yet suﬃciently cover information that is relevant for data accountability. To ﬁll this gap, this paper proposes LiQuID, a novel metadata model to make datasets accountable throughout their life cycle. It is more general than existing metadata models, which can be mapped to LiQuID. We validate LiQuID for the purpose of dataset accountability based on a real-world workload we created.
Different Perivascular Space Burdens in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease

Background Excessive aggregation of α-synuclein is the key pathophysiological feature of Parkinson’s disease (PD). Rapid eye movement sleep behavior disorder (RBD) is also associated with synucleinopathies and considered as a powerful predictor of PD. Growing evidence suggests the diminished clearance of α-synuclein may be partly attributable to poor interstitial fluid drainage, which can be reflected by magnetic resonance imaging (MRI)-visible enlarged perivascular space (EPVS). However, the effect of MRI-visible EPVS on iRBD and PD, and their correlation with clinical characteristics remain unclear. Objective To evaluate the clinical and neuroimaging significance of MRI-visible EPVS in iRBD and PD patients. Methods We enrolled 33 iRBD patients, 82 PD (with and without RBD) patients, and 35 healthy controls (HCs), who underwent clinical evaluation and 3.0 Tesla MRI. Two neurologists assessed MRI-visible EPVS in centrum semiovale (CSO), basal ganglia (BG), substantia nigra (SN), and brainstem (BS). Independent risk factors for iRBD and PD were investigated using multivariable logistic regression analysis. Spearman analysis was used to test the correlation of MRI-visible EPVS with clinical characteristics of patients. Results iRBD patients had significantly higher EPVS burdens (CSO, BG, SN, and BS) than PD patients. Higher CSO-EPVS and BS-EPVS burdens were independent risk factors for iRBD. Furthermore, higher CSO-EPVS and SN-EPVS burdens were positively correlated with the severity of clinical symptom in iRBD patients, and higher BG-EPVS burden was positively correlated with the severity of cognitive impairment in PD patients. Conclusion iRBD and PD patients have different MRI-visible EPVS burdens, which may be related with a compensatory mechanism in glymphatic system. Lower MRI-visible EPVS burden in PD patients may be a manifestation of severe brain waste drainage dysfunction. These findings shed light on the pathophysiologic relationship between iRBD and PD with respect to neuroimaging marker of PD.
Six Exonic Variants in the SLC5A2 Gene Cause Exon Skipping in a Minigene Assay

Background Familial renal glucosuria is a rare renal tubular disorder caused by SLC5A2 gene variants. Most of them are exonic variants and have been classified as missense variants. However, there is growing evidence that some of these variants can be detrimental by affecting the pre-mRNA splicing process. Therefore, we hypothesize that a certain proportion of SLC5A2 exonic variants can result in disease via interfering with the normal splicing process of the pre-mRNA. Methods We used bioinformatics programs to analyze 77 previously described presumed SLC5A2 missense variants and identified candidate variants that may alter the splicing of pre-mRNA through minigene assays. Results Our study indicated six of 7 candidate variants induced splicing alterations. Variants c.216C > A, c.294C > A, c.886G > C, c.932A > G and c.962A > G may disrupt splicing enhancer motifs and generate splicing silencer sequences resulting in the skipping of exon 3. Variants c.305C > T and c.1129G > A probably disturb splice sites leading to exon skipping. Conclusion To our knowledge, we report, for the first time, SLC5A2 exonic variants that produce alterations in pre-mRNA. Our research reinforces the importance of assessing the consequences for putative point variants at the mRNA level. Additionally, we propose that minigenes function analysis may be valuable to evaluate the impact of SLC5A2 exonic variants on pre-mRNA splicing without patients’ RNA samples.
Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development

In mammals, developing ovarian follicles transform from primordial follicles to primary follicles, secondary follicles, and mature follicles, accompanied by changes in follicular secretory functions. FoxO3a is a member of the forkhead transcription factor family (FoxO), which plays an important role in the cell cycle, DNA damage repair, apoptosis, oxidative stress, and energy metabolism. Recent studies have shown that FOXO3a is involved in the physiological regulation of follicular development and pathological progression of related ovarian diseases, which will provide useful concepts and strategies for retarding ovarian aging, prolonging the ovarian life span, and treating ovarian diseases. Therefore, the regulation of FOXO3a expression, as well as the physiological contribution during ovarian follicular development are detailed in this paper, presenting an important reference for the further study of ovarian biology.
Vibration Alert to the Brain: Evoked and Induced MEG Responses to High-Frequency Vibrotactile Stimuli on the Index Finger of Dominant and Non-dominant Hand

Background: In recent years, vibrotactile haptic feedback technology has been widely used for user interfaces in the mobile devices. Although functional neuroimaging studies have investigated human brain responses to different types of tactile inputs, the neural mechanisms underlying high-frequency vibrotactile perception are still relatively unknown. Our aim was to investigate neuromagnetic brain responses to high-frequency vibrotactile stimulation, using magnetoencephalography (MEG). Methods: We measured 152-channel whole-head MEG in 30 healthy, right-handed volunteers (aged 20–28 years, 15 females). A total of 300 vibrotactile stimuli were presented at the tip of either the left index finger or the right index finger in two separate sessions. Sinusoidal vibrations at 150 Hz for 200 ms were generated with random inter-stimulus intervals between 1.6 and 2.4 s. Both time-locked analysis and time-frequency analysis were performed to identify peak responses and oscillatory modulations elicited by high-frequency vibrations. The significance of the evoked and induced responses for dominant and non-dominant hand stimulation conditions was statistically tested, respectively. The difference in responses between stimulation conditions was also statistically evaluated. Results: Prominent peak responses were observed at 56 ms (M50) and at 100 ms (M100) for both stimulation conditions. The M50 response revealed clear dipolar field patterns in the contralateral side with significant cortical activations in the contralateral primary sensorimotor area, whereas the M100 response was not as prominent as the M50. Vibrotactile stimulation induced significant suppression of both alpha (8–12 Hz) and beta (20–30 Hz) band activity during the mid-latency period (0.2–0.4 s), primarily in sensorimotor areas contralateral to the stimulation side. In addition, a significant alpha enhancement effect in posterior regions was accompanied with alpha suppressions in sensorimotor regions. The alpha suppression was observed in a broader distribution of cortical areas for the non-dominant hand stimulation. Conclusion: Our data demonstrate that high-frequency tactile vibrations, which is known to primarily activate Pacinian corpuscles, elicit somatosensory M50 and M100 responses in the evoked fields and induce modulations of alpha and beta band oscillations during mid-latency periods. Our study is also consistent with that the primary sensorimotor area is significantly involved in the processing of high-frequency vibrotactile information with contralateral dominance.