Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of a revised care plan for babies with retinopathy of prematurity during SARS-CoV-2 pandemic in India

Purpose: To analyze the impact of a revised care plan for retinopathy of prematurity (ROP) during SARS-CoV-2 pandemic in a tertiary eye care facility in eastern India. Methods: In a retrospective study, we analyzed the medical records of babies managed for ROP during the peak of the SARS-CoV-2 pandemic, with particular reference to the challenges, and the revised strategies addressing travel restrictions for five months, from April to August 2020. The strategy included selective referral (babies with higher treatment probability), longer follow-up intervals (babies with non-alarming findings), use of locally available workforce, and teleconsultation whenever feasible. Results: In the given period, 222 babies were examined versus 624 in the preceding year (P = 0.001). The average gestational age, birth weight, and postmenstrual age at presentation were 30.4 weeks, 1.31 kg, and 37.7 weeks, respectively. The first examination was on time in 40.1% of babies but was delayed by a median of 23 days in the remaining babies. In the cohort, 56.7% of babies had any ROP, and 27.9% required treatment (versus 8.8% in the previous year; P < 0.001). The intravitreal anti–vascular growth factor (anti-VEGF) injection was more often used than in the previous year (n = 72 vs 36; P < 0.0001). The treatment outcome was comparable before and after the SARS-CoV-2 lockdown period. There was no report of health issues among the care providers attributable to ROP care. Conclusion: The revised strategy resulted in a smaller pool of babies screened but a larger proportion of babies treated for ROP. This strategy could be used more profitably in future ROP care.
Predictors of time in target glucose range in real‐world users of the MiniMed 780G system

Automated insulin delivery systems have improved glycaemic control in people with type 1 diabetes mellitus. The analysis investigated predictors of improved sensor glucose time‐in‐range (TIR; 70‐180 mg/dl) based on real‐world use of the MiniMed 780G advanced hybrid closed‐loop (AHCL) system.
Effectiveness of personal protection measures against Lyme disease: A review of epidemiologic studies from the United States

Lyme disease, the most commonly reported vector‐borne disease in the United States, is caused by the bacteria Borrelia burgdorferi and is transmitted through the bite of an infected blacklegged tick. In the absence of a licensed vaccine, the prevention of Lyme disease relies heavily on limiting tick exposure. Methods for limiting tick exposure include personal protection measures such as repellent use, wearing protective clothing, avoiding areas where ticks may be present, bathing after exposure to tick habitat and performing regular tick checks. Public health officials typically recommend all these personal protection measures; however, there is limited evidence to promote one behaviour or practice over another. The focus of this article is to review available literature that examines the effectiveness of recommended personal protection measures to prevent Lyme and other Ixodes‐transmitted diseases in humans. Articles included in this review were identified through Google Scholar and PubMed searches using specific search terms. We identified over 56,000 articles using Google Scholar and PubMed searches. Of those, 16 studies fit our criteria for inclusion and were reviewed in their entirety. Among the personal protection measures evaluated, no intervention was predominantly or consistently effective across studies, demonstrating that, currently, there is no single best method for primary prevention of Ixodes‐transmitted diseases in the United States. Frequently recommended practices such as tick checks, repellent use and protective clothing had mixed results across studies. Study design differences limited comparability among studies, and sample sizes for these studies may have been too small to detect statistically significant results even if a prevention method was effective. Though many of the reviewed personal protection measures are frequently recommended to the public, limited evidence demonstrates their ability to prevent tick‐borne disease. Additional standardized studies are needed to evaluate personal protection measures.
The 2 Micron Spectrum of L1551 IRS 5

Two-micron spectroscopy of L1551 IRS 5 is presented. The main result is the presence of strong absorption in the first-overtone bands of CO. From the equivalent width of the CO bands, a spectral type of K2 III is derived. The CO bands and marginal evidence for H/sub 2/O vapor absorption provide additional evidence that IRS 5 may be a member of the FU Ori class of pre-main-sequence stars. Emission lines of H/sub 2/ are detected, suggesting the presence of shocked molecular gas in the vicinity of IRS 5. A marginal detection of the hydrogen Br-gamma line was also made. The measured flux limit for Br-gamma and the 6-cm radio continuum flux are consistent with optically thin recombination and not with an optically thick wind. 27 references.
Designing the learning of intraprofessional collaboration among medical residents

To preserve quality and continuity of care, collaboration between primary‐care and secondary‐care physicians is becoming increasingly important. Therefore, learning intraprofessional collaboration (intraPC) requires explicit attention during postgraduate training. Hospital placements provide opportunities for intraPC learning, but these opportunities require interventions to support and enhance such learning. Design‐Principles guide the design and development of educational activities when theory‐driven Design‐Principles are tailored into context‐sensitive Design‐Principles. The aim of this study was to develop and substantiate a set of theory‐driven and context‐sensitive Design‐Principles for intraPC learning during hospital placements.
Genetic testing in four Indian families with suspected Stickler syndrome

Purpose: Stickler syndrome is associated with the development of rhegmatogenous retinal detachment (RRD), and often presents with ocular, auditory, skeletal, and orofacial abnormalities. Molecular analysis has proven effective in diagnosis, confirmation and classification of the disease. We aimed to describe the utility of next-generation sequencing (NGS) in genetic analysis of four Indian families with suspected Stickler syndrome. Methods: The index cases presented with retinal detachment with family history. Genetic analysis in the index case was performed by next-generation sequencing of inherited retinal degeneration genes, and validated by Sanger sequencing followed by co-segregation analysis in the other family members. Results: Twenty patients were included for the genetic analysis (15 males and 5 females from four families). Clinical details were available for 15 patients (30 eyes). Fourteen eyes (11 patients) developed RRD. In the 16 eyes without RRD, 8 underwent barrage laser to lattice degeneration and 8 were under observation. Disease segregating heterozygous mutations with pathogenic/likely pathogenic effect was identified in COL2A1 (c.4318-1G>A, c.141G>A, c.1221+1G>A for 3 families) and COL11A1 (c.1737+1 G>A for 1 family) gene. In addition to the mutation in the COL2A1 gene, a pathogenic heterozygous variant associated with risk for arrhythmogenic right ventricular cardiomyopathy (ARVC) was identified in one member. Conclusion: NGS testing confirmed the presence of the causative gene for Stickler syndrome in the index case followed by evaluation of family members and confirmation of genetic and ocular findings. We believe that this may be the first such report of families with RRD from India.
ABO, secretor, and Lewis carbohydrate histo‐blood groups are associated with autoimmune neutropenia of early childhood in Danish patients

Autoimmune neutropenia of early childhood (AIN) is caused by autoantibodies directed against antigens on the neutrophil membrane. The ABO, secretor, and Lewis histo‐blood group systems control the expression of carbohydrate antigens and have previously been linked to autoimmune diseases. We aimed to investigate the association between genotypes and the risk of AIN in Danish patients.
Self-monitoring and former best friends: individual differences in friendship dissolution

Abstract Across two investigations, we explored self-monitoring differences in the causes of relationship dissolution with best friends and if such differences are best captured by a univariate model or bivariate model of self-monitoring. Causes of friendship dissolution often mirror the reasons for friendship formation. Accordingly, we hypothesized that high self-monitors would report a change in shared activities as the reason for dissolving a relationship with a best friend, whereas low self-monitors would report a change in personal compatibility as the reason for dissolving a relationship with a best friend. In both studies, participants focused on a former best friend and indicated which of two causes (Study 1: loss of shared activities vs. loss of shared attitudes and values; Study 2: change in life circumstances vs. change in broad dispositions) was more influential in ending that friendship. They also completed the Self-Monitoring Scale; scores were used to create indices of self-monitoring in its univariate and bivariate (acquisitive vs. protective) forms. In both studies, protective self-monitoring was more consistently related to reasons for friendship dissolution, such that (a) high self-monitoring was associated with a loss of shared interests and (b) low self-monitoring was associated with a loss of personal compatibility as the bases for friendship dissolution. Effects were independent of potential third variables. Implications (e.g., nuanced assessment of self-monitoring), limitations (e.g., absence of longitudinal designs), and future directions (e.g., examining actor-partner effects) are discussed.
Individual's Reproductive Strategies Moderates the Association Between Facial Width-to-Height and Risk-Taking Propensity

Previous research has yielded mixed findings on the relationship between facial width-to-height ratio (fWHR), an androgen-dependent feature, and risk-taking propensity. We argue that mixed findings might result from overlooked variables. Given that risk-taking propensity might be ultimately linked to a search for mating opportunities, we analyze if reproductive strategies moderate the relationship between fWHR and risk-taking propensity. Our results, obtained from a sample of 434 male participants, show a positive association between fWHR and recreational and social risk-taking only for men who are more motivated to focus on mating effort over offspring survival. This finding aligns with research arguing that risk-taking may be a mating strategy since being social and recreational risk-prone might illustrate physical and psychological qualities and improve one's ability to attract mates. Our results support the notion that risk-taking might be a domain-specific construct. Overall, our research is in line with recent findings suggesting that the impact of testosterone exposure on risk-taking propensity is best understood when considering the role of contextual variables. Consequently, we add to previous research that studies related to risk-taking propensity should account for reproductive strategies.
Commentary: Surgical challenges associated with the management of retinal detachment associated with chorioretinal coloboma

Ocular coloboma is a congenital defect caused by incomplete closure of the embryonic fissure during embryonic development. It can cause defects in the iris, crystalline lens, zonules, ciliary body, retina, choroid, and/or optic disc. [1] Nakamura et al.[2] reported isolated anterior segment, isolated posterior segment and involvement of both in around 36%, 39% and 24% cases respectively. The incidence of choroidal coloboma in the general population has been estimated to be around 0.14%. [3] It can be associated with retinal detachment (RD) in 2.4%–47.5% of eyes. [1] Uhumwangho et al.[4] showed that the chances of RD increased by a factor of 1.147 per year of the patient’s age. Histological studies have shown that the neurosensory retina is replaced by a rudimentary structure called intercalary membrane (ICM), while retinal pigment epithelium, Bruch’s membrane, choriocapillaris and choroid are absent. [1]
Trajetória e tendências dos cursos de enfermagem no Brasil

El texto analiza el camino de la educacion de enfermeria en Brasil y las tendencias de los cursos del grado (1991-2004) y polilla un perfil del estudiante graduacion en enfermeria han participado en el Examen Nacional de Cursos (ENADE), en 2004. Para dibujar el referido 18 indicadores del companero-familia y los respondentes al perfil de los academicos de la encuesta del estudiante ellos se usan. Se apuntan un poco de perspectivas y desafios a la educacion em enfermeria en el pais, con las vistas para subvencionar a educadores y estudiantes en el his/her la practica academica.
Organisational change to integrate self-management into specialised mental health services: Creating collaborative spaces.

INTRODUCTION Self-management support for schizophrenia has become expected practice leaving organisations to find ways for feasible implementation. Self-management support involves a foundational cultural shift for traditional disease-based services, new ways of clients-providers working together, coupled with delivering a portfolio of tools and techniques. A new model of self-management support embedded into traditional case management services, called SET for Health (Self-management Engaging Together for Health), was designed and tailored to make such services meaningfully accessible to clients of a tertiary care centre. This paper describes the proof of concept demonstration efforts, the successes/challenges, and initial organisational changes. METHOD An integrated knowledge translation approach was selected as a means to foster organisational change grounded in users' daily realities. Piloting the model in two community case management programmes, we asked two questions: Can a model of self-management support be embedded in existing case management and delivered within routine specialised mental health services? What organisational changes support implementation? RESULTS Fifty-one clients were enroled. Indicators of feasible delivery included 72.5% completion of self-management plans in a diverse sample, exceeding the 44% set minimum; and an attrition rate of 21.6%, less than 51% set maximum. Through an iterative evaluation process, the innovation evolved to a targeted hybrid approach revolving around client goals and a core set of co-created reference tools, supplemental tools and resources. Operationalisation by use of tools was implemented to create spaces for client-provider collaborations. Monitoring of organisational changes identified realignment of practices. Changes were made to procedures and operations to further spread and sustain the model. CONCLUSION This study demonstrated how self-management support can be implemented, within existing resources, for routine delivery of specialised services for individuals living with schizophrenia. The model holds promise as a hybrid option for supporting clients to manage their own health and wellness.
CircCOL1A2 Sponges MiR-1286 to Promote Cell Invasion and Migration of Gastric Cancer by Elevating Expression of USP10 to Downregulate RFC2 Ubiquitination Level

Gastric cancers (GC) are generally malignant tumors, occurring with high incidence and threatening public health around the world. Circular RNAs (circRNAs) play crucial roles in modulating various cancers, including GC. However, the functions of circRNAs and their regulatory mechanism in colorectal cancer (CRC) remain largely unknown. This study focuses on both the role of circCOL1A2 in CRC progression as well as its downstream molecular mechanism. Quantitative polymerase chain reaction (qPCR) and western blot were adopted for gene expression analysis. Functional experiments were performed to study the biological functions. Fluorescence in situ hybridization (FISH) and subcellular fraction assays were employed to detect the subcellular distribution. Luciferase reporter, RNA-binding protein immunoprecipitation (RIP), co-immunoprecipitation (Co-IP), RNA pull-down, and immunofluorescence (IF) and immunoprecipitation (IP) assays were used to explore the underlying mechanisms. Our results found circCOL1A2 to be not only upregulated in GC cells, but that it also propels the migration and invasion of GC cells. CircCOL1A2 functions as a competing endogenous RNA (ceRNA) by sequestering microRNA-1286 (miR-1286) to modulate ubiquitin-specific peptidase 10 (USP10), which in turn spurs the migration and invasion of GC cells by regulating RFC2. In sum, CircCOL1A2 sponges miR-1286 to promote cell invasion and migration of GC by elevating the expression of USP10 to downregulate the level of RFC2 ubiquitination. Our study offers a potential novel target for the early diagnosis and treatment of GC.
Swarms of chemically modified antiviral siRNA targeting herpes simplex virus infection in human corneal epithelial cells

Herpes simplex virus type 1 (HSV-1) is a common virus of mankind and HSV-1 infections are a significant cause of blindness. The current antiviral treatment of herpes infection relies on acyclovir and related compounds. However, acyclovir resistance emerges especially in the long term prophylactic treatment that is required for prevention of recurrent herpes keratitis. Earlier we have established antiviral siRNA swarms, targeting sequences of essential genes of HSV, as effective means of silencing the replication of HSV in vitro or in vivo. In this study, we show the antiviral efficacy of 2´-fluoro modified antiviral siRNA swarms against HSV-1 in human corneal epithelial cells (HCE). We studied HCE for innate immunity responses to HSV-1, to immunostimulatory cytotoxic double stranded RNA, and to the antiviral siRNA swarms, with or without a viral challenge. The panel of studied innate responses included interferon beta, lambda 1, interferon stimulated gene 54, human myxovirus resistance protein A, human myxovirus resistance protein B, toll-like receptor 3 and interferon kappa. Our results demonstrated that HCE cells are a suitable model to study antiviral RNAi efficacy and safety in vitro. In HCE cells, the antiviral siRNA swarms targeting the HSV UL29 gene and harboring 2´-fluoro modifications, were well tolerated, induced only modest innate immunity responses, and were highly antiviral with more than 99% inhibition of viral release. The antiviral effect of the 2’-fluoro modified swarm was more apparent than that of the unmodified antiviral siRNA swarm. Our results encourage further research in vitro and in vivo on antiviral siRNA swarm therapy of corneal HSV infection, especially with modified siRNA swarms.
Wi-Fi Technology and Human Health Impact: A Brief Review of Current Knowledge

Abstract An enormous increase in the application of wireless communication in recent decades has intensified research into consequent increase in human exposure to electromagnetic (EM) radiofrequency (RF) radiation fields and potential health effects, especially in school children and teenagers, and this paper gives a snap overview of current findings and recommendations of international expert bodies, with the emphasis on exposure from Wi-Fi technology indoor devices. Our analysis includes over 100 in vitro, animal, epidemiological, and exposure assessment studies (of which 37 in vivo and 30 covering Wi-Fi technologies). Only a small portion of published research papers refers to the “real” health impact of Wi-Fi technologies on children, because they are simply not available. Results from animal studies are rarely fully transferable to humans. As highly controlled laboratory exposure experiments do not reflect real physical interaction between RF radiation fields with biological tissue, dosimetry methods, protocols, and instrumentation need constant improvement. Several studies repeatedly confirmed thermal effect of RF field interaction with human tissue, but non-thermal effects remain dubious and unconfirmed.
Diagnostic accuracy of endoscopic ultrasound with artificial intelligence for gastrointestinal stromal tumors: A meta‐analysis

Gastrointestinal stromal tumors (GISTs) are thought to have a malignant potential. However, utilizing endoscopic ultrasound (EUS) to differentiate GISTs from other types of subepithelial lesions (SELs) remains challenging. Artificial intelligence (AI)‐based diagnostic systems for EUS have been reported to have a promising performance, although the results of the previous studies remain controversial. In this meta‐analysis, we aimed to assess the diagnostic accuracy of AI‐based EUS in distinguishing GISTs from other SELs.
Comparison of Changes in the Optic Nerve Sheath Diameter Following Thoracic Epidural Normal Saline Injection in Laparoscopic Surgery.

BACKGROUND Thoracic epidural analgesia is useful for postoperative pain control after upper abdominal surgery. However, epidural analgesia in patients undergoing laparoscopic surgery may potentiate an increase in intracranial pressure (ICP). ICP can be effectively evaluated by measuring the optic nerve sheath diameter (ONSD). OBJECTIVES The purpose of this study is to investigate changes in the ONSD following thoracic epidural normal saline injection during laparoscopic surgery. STUDY DESIGN Prospective randomized trial. SETTING An interventional pain management clinic in South Korea. METHOD This study included 60 patients receiving thoracic epidural catheterization for postoperative pain control following laparoscopic or open gastrectomy. Patients were divided into 3 groups. The open group consisted of patients undergoing open gastrectomy without epidural normal saline injection. The lapa-saline and lapa groups consisted of patients undergoing laparoscopic gastrectomy with and without 10 mL epidural normal saline injection, respectively. The ONSD was measured using ultrasound at 4 time points. RESULTS The lapa-saline group showed the most pronounced increase in the ONSD compared to the open and lapa groups at the time points of T1 and T2. Only the lapa-saline group demonstrated 4 patients with ONSD values of more than 5.8 mm. The increase in the ONSD continued even after the deflation of pneumoperitoneum in the lapa-saline group, whereas the ONSD in the lapa group returned to near baseline value after the deflation of pneumoperitoneum. LIMITATIONS Epidural normal saline was injected instead of a local anesthetic to prevent the occurrence of hypotension. However, the injection of epidural normal saline is considered to be the same physiological condition causing elevation of ICP compared with epidural injection with local anesthetics. CONCLUSIONS The lapa-saline group showed the most pronounced increase in the ONSD. The ONSD values higher than 5.8 mm were observed only in the lapa-saline group. The increase in the ONSD continued even after the deflation of pneumoperitoneum only in the lapa-saline group.
Estimated Number of COVID-19 Infections, Hospitalizations, and Deaths Prevented Among Vaccinated Persons in the US, December 2020 to September 2021

Key Points Question How many SARS-CoV-2 infections and COVID-19–associated hospitalizations and deaths have been prevented among vaccinated persons by the US COVID-19 vaccination program? Findings In this modeling study, COVID-19 vaccination was estimated to prevent 27 million SARS-CoV-2 infections, 1.6 million COVID-19–associated hospitalizations, and 235 000 COVID-19–associated deaths among vaccinated persons 18 years or older from December 1, 2020, to September 30, 2021. By September 30, 2021, vaccination prevented an estimated 52% of expected infections, 56% of expected hospitalizations, and 58% of expected deaths. Meaning The US COVID-19 vaccination program was estimated to prevent substantial morbidity and mortality through direct protection of vaccinated individuals.