Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumour suppressor gene methylation and renal cell carcinoma risk: a comprehensively systematic review and meta-analysis

Purpose: Renal cell carcinoma (RCC) is becoming more common as a urinary system malignancy. There is a growing body of evidence supporting an important role of DNA methylation alteration involved in the initiation of RCC, but the current findings are inconsistent and controversial. Thus, we performed this systematic review and meta-analysis to comprehensively assess the associations between methylation status of tumour suppressor genes and the incidence risk of RCC. Methods: This study has been registered on PROSPERO (CRD42019130782) and was reported according to the PRISMA guidelines. We systematically searched the PubMed, EMBASE and CNKI databases for relevant studies. The effect estimates were summarized using random-effect models. Results: A total of 21 case-control studies containing 1,912 participants were included. Overall, abnormal hypermethylation of RASSF1A was associated with a significantly increased risk of RCC (OR, 6.612, 95% CI: 1.926-22.697, P = 0.003), especially in the American populations (OR, 18.429, 95% CI: 3.072-110.536, P = 0.001). An increased RCC risk was also associated with hypermethylation of SFRP1 and GSTP1 (OR, 3.995, 95% CI: 1.607-9.934, P = 0.003; OR, 4.508, 95% CI: 1.004-20.239, P = 0.049; respectively); however, the results for SFRP1 and GSTP1 were non-conclusive due to the limited number of studies included and the inconsistency across sensitivity analyses. There was no obvious association for the other genes. Conclusion: This study demonstrated a statistically and robustly positive association of aberrant hypermethylation of RASSF1A with an increased risk of developing RCC, indicating a potentially useful biomarker to predict the RCC incidence risk.
The impact of synoptic weather on UK surface ozone and implications for premature mortality

Air pollutants, such as ozone, have adverse impacts on human health and cause, for example, respiratory and cardiovascular problems. In the United Kingdom (UK), peak surface ozone concentrations typically occur in the spring and summer and are controlled by emission of precursor gases, tropospheric chemistry and local meteorology which can be influenced by large-scale synoptic weather regimes. In this study we composite surface and satellite observations of summer-time (April to September) ozone under different UK atmospheric circulation patterns, as defined by the Lamb weather types. Anticyclonic conditions and easterly flows are shown to significantly enhance ozone concentrations over the UK relative to summer-time average values. Anticyclonic stability and light winds aid the trapping of ozone and its precursor gases near the surface. Easterly flows (NE, E, SE) transport ozone and precursor gases from polluted regions in continental Europe (e.g. the Benelux region) to the UK. Cyclonic conditions and westerly flows, associated with unstable weather, transport ozone from the UK mainland, replacing it with clean maritime (North Atlantic) air masses. Increased cloud cover also likely decrease ozone production rates. We show that the UK Met Office regional air quality model successfully reproduces UK summer-time ozone concentrations and ozone enhancements under anticyclonic and south-easterly conditions for the summer of 2006. By using established ozone exposure-health burden metrics, anticyclonic and easterly condition enhanced surface ozone concentrations pose the greatest public health risk.
Tone of Textual Information in Annual Reports and Regulatory Inquiry Letters: Data from China

ABSTRACT This paper examines the impact of the tone used in the annual reports of listed companies on the probability of regulatory inquiries from 2014 to 2019. The empirical results verify that the more positive tone of the annual report, the more it can exert a psychological framing effect, which makes the regulator less likely to issue an annual report inquiry letter. Further analysis shows that this impact that the tone of annual reports has on the probability of a regulatory inquiry is significantly weakened when the company has irregularities or has been issued a modified audit opinion by the auditor. Overall, the results provide the basis for the government to regulate the information disclosure of the annual reports.
Motivating Online Learning through Project-Based Learning During the 2020 COVID-19 Pandemic

The transition of traditional schooling to online learning during the COVID-19 pandemic disrupted formal school education. Though at home, teachers and students continued teaching and learning in socially distant ways using online technologies. From various teacher surveys, only about 60% of students in the United States regularly engaged with learning activities. Teachers and parents also expressed a significant need for help to keep students motivated and engaged in learning activities. During the pandemic, online learning left teachers and parents needing support for learning activities that motivate and engage students. Project-based learning is an increasingly popular pedagogical practice centered around students working collaboratively on projects while the teacher facilitates learning activities and progression. Project-based learning embodies several factors considered central to motivation in online learning. In this paper, we inquire how this approach presents itself as a candidate for learning during the pandemic when considering students’ motivation to learn through online learning experiences. We construct a conceptual framework informed by motivational theories that share core tenets with this form of learning and use the framework to analyze interviews of 11 teachers from 4 schools that taught with a project-based learning approach before the pandemic and transitioned to teaching, using it online, in the Spring of 2020. From our analyses of the teachers’ narratives, we discuss teaching aspects of the approach that lend themselves well to online teaching, elements that the teachers believe are missing, and how educators might cater to these missing aspects with a focus on student motivation to learn.
Effects of the Fuel-Air Mixing on Combustion Instabilities and NOx Emissions in Lean Premixed Combustion

i Acknowledgments . iv List of Figures . ix List of Tables . xiv List of Symbols . xv Chapter 1: Introduction . 1 1.1 Nitrogen oxides . 1 1.1.1 Thermal NOx . 1 1.1.2 Nitrous oxide (N2O) mechanism . 3 1.1.3 Prompt NO . 3 1.1.4 Fuel NO . 4 1.2 Lean Premixed Combustion . 5 1.3 Fuel-Air Mixing . 10 1.3. 1 Fuel-Air Mixing Measurement Techniques . 11 1.3. 1.1 Point Based Measurements . 11 1.3. 1.2 Whole Field Measurement Techniques . 13 1.3. 2 Effect of Fuel-Air Mixing on NOx Emissions . 14 1.4 Combustion Instabilities in LPM Combustion . 16 1.4. 1 Effect of Fuel-Air Mixing on Combustion Instabilities . 17 1.4. 2 Vortex Shedding Due to Hydrodynamic Instability . 18 1.5 Motivation and Scope of Work . 20 Chapter 2: Experimental Procedure . 24 2.1 Test Setup and Experimental Facility . 24 2.1.1 The Premixer . 24
A Novel Method for Preparing Calcium Carbonate Particles: Thermal Decomposition from Calcium Hydrogen Carbonate Solution

An entirely novel preparation method of calcium carbonate (CaCO3) from calcium hydrogen carbonate (Ca (HCO3)2) solution was presented and named as thermal decomposition. The variation of the polymorphs and morphologies of CaCO3 particles with reaction temperature was investigated. XRD result indicates that high temperature favors the formation of calcite. Cubic or rhombohedra calcite crystals, lamellar and spherical vaterite crystals and rod– and needle–like aragonite crystals are found in powder synthesized at different temperatures. The reaction process was also discussed in the present work.
Prevalence of pneumonia associated with measles among infants and children hospitalized in Khyber Teaching Hospital Peshawar, KPK, Pakistan

The current study aimed to assess the prevalence and potential risk factors associated with the occurrence of pneumonia among people of Khyber Pakhtunkhwa. Pneumonia is one of the leading causes of children age less than 5 years. Acute Respiratory Tract is one of the leading causes of Pneumonia; the ratio of death due to pneumonia is 50% more in developing countries. Air pollution, concrete fuel for food preparation are the major sources of respiratory Tract Infection (RTI). RTI can cause 42% of death around the world. Hemolytic streptococci have the organisms that most prevailing in the lungs cause of Pneumonia which can lead to measles. The present study highlights the prevalence in Khyber Pakhtunkhwa, 61.8 % child, and 38.2% was infants. Male and Female ratios were 31.4 % and 68.6 % respectively. The economic loss among poor families in percentage was high 60%, whereas middle and high economic status families were 30% and 10% respectively. The occurrences of the percentage of rural and urban were about 51% and 49% respectively.
Effect of refrigeration and pasteurisation on storage stability of Kunu

Kunu, a refreshing, nutritious non-alcoholic beverage from millet, is the midday meal for most people of Northern parts of West Africa. Kunu has a short shelf-life due to souring caused by microbial fermentation. The preservation of kunu through a thermal process must consider the possibility of compromising the aroma and mouthfeel of the product at the temperature required for inactivating the souring bacteria. The objective of this study was to evaluate the effects of pasteurisation temperature/time combinations and refrigeration on the shelf stability of kunu. Also recorded the changes in the concentrations of some nutrient components of millet during conversion into kunu. Proximate chemical composition, flavanol content, vitamin A and B 2 contents and gross energy of millet and kunu were determined. Pasteurised and unpasteurised kunu were stored at refrigerated (4-7°C) and at ambient temperature (32 ± 2°C) for six days. The effects of pasteurisation (temperature/time combinations) and refrigeration on the pH, sensory quality and sedimentation of kunu were determined. Protein, fat, ash and crude fibre contents of millet grain were lowered in kunu. During the conversion of millet grain to kunu vitamin A, vitamin B 2 , gross energy, and flavanol content of the grain were lowered. Refrigeration and pasteurisation delayed and decreased the decline of pH, increased the shelf-life of the product and reduced the sedimentation of suspended particles. Pasteurisation at 65°C for 20 min and 75°C for 10 min were more effective than pasteurisation at 60°C for 30 min in delaying pH decline, increasing the shelf-life, and reducing sedimentation of kunu.
Oversampling technique in student performance classification from engineering course

The first year of an engineering student was important to take proper academic planning. All subjects in the first year were essential for an engineering basis. Student performance prediction helped academics improve their performance better. Students checked performance by themselves. If they were aware that their performance are low, then they could make some improvement for their better performance. This research focused on combining the oversampling minority class data with various kinds of classifier models. Oversampling techniques were SMOTE, Borderline-SMOTE, SVMSMOTE, and ADASYN and four classifiers were applied using MLP, gradient boosting, AdaBoost and random forest in this research. The results represented that Borderline-SMOTE gave the best result for minority class prediction with several classifiers.
CHLA standards for library and information services in Canadian health & social services institutions 2020

The following standards, with supporting evidence, are intended to serve as a guide to structuring minimum library services within health and social services institutions across all Canadian provinces and territories. The Standards are not intended to be aspirational. The aim of the Task Force was to ensure that the Standards update would not be so removed from the current realities and landscape that they became unattainable to many libraries. For this reason, some Standards outline requirements that are essential to the minimum function of the library, and other Standards provide recommendations only. The intended use of the Standards is to set a baseline for the provision of essential library services and resources and aid in advocating for adequate resources. It is important to note, however, that the Task Force does not intend for the Standards to prevent libraries from reaching a more advanced level of service, and we hope that in their current form they will not be a hindrance to excellence or innovation. Once published, the version of the Standards made freely available on the Canada Health Libraries Association website [1] shall henceforth and always be considered the most recent and active version of the Standards and is the version that should be used to inform practice. The Standards Standing Committee will institute a regular review and updating schedule, ensuring the currency of the Standards.
Structural and thermodynamic properties of sodium actinide ternary oxides

I n the potential event of a clad breach in a Sodium-cooled Fast Reactor (SFR), the sodium metallic coolant could come into contact with the (U,Pu,Np)O2 nuclear fuel. The reaction products are numerous, but there is little knowledge of their structural and thermodynamic properties. Under the oxygen potential conditions of the reactor, pentavalent Na3AnO4 (An=U,Pu,Np) is expected to form, but its structure was the subject of controversy until now. We showed that α-Na3UO4 adopts a monoclinic symmetry in space group P2/c. Neutron di raction combined with X-ray Absorption Near Edge Structure (XANES) spectroscopy at the U-M4 edge also revealed that this phase could accommodate excess sodium on the uranium site, with subsequent charge compensation of the uranium cation from U(V) to U(VI), which was not previously foreseen. The corresponding mixed valence state composition is written Na3(U1−x,Nax)O4 with 0<x<0.16(2). To complete the data on the Na-U-O system, the thermodynamic functions of Na2U2O7 and Na4UO5 were evaluated using Knudsen e usion mass spectrometry (KEMS) and thermal-relaxation calorimetry. In addition, the oxygen content required at 900 K within liquid sodium to form pentavalent Na3UO4 and hexavalent Na4UO5 were calculated to be 0.7 and 1.5 wppm, respectively, which are levels typically encountered in SFRs. A thermodynamic model for the Np-O system was then developed using the CALPHAD method. This is particularly relevant since it is envisaged to incorporate minor actinides into the fuel to minimize the nuclear waste inventory. The poorly known structures of the NaNp-O and Na-Pu-O phases diagrams, i.e., tetravalent Na2AnO3 (An=Np,Pu), pentavalent Na3AnO4, hexavalent Na4AnO5 and α-Na2NpO4, and heptavalent Na5AnO6, were also rened by the Rietveld method. The structures of Na3NpO4 and Na3PuO4 were determined ab initio from powder X-ray di raction data, and found to be orthorhombic in the space group Fmmm. The valence states of the neptunium cations were con rmed from the isomer shift values of their Mössbauer spectra. Having established the charge states without ambiguity, XANES spectra were collected at the Np-L3 and Pu-L3 edges to serve as reference data for An(V), An(VI), and An(VII) oxide phases in the solid state. Finally, KEMS studies of αNa2NpO4 showed very promising results for the determination of the enthalpies of formation of the sodium neptunates and plutonates, for which there is almost no data available. The heat capacities and entropies at 298.15 K of α-Na2NpO4, Na4NpO5, Na5NpO6, and Na5PuO6 were also determined. Comparing their Gibbs energy values, the sodium neptunates were found to be slightly more stable than their isostructural uranium analogues.
Wetting on Real Surfaces

Recent advances regarding the measurement and theory of equilibrium contact angles on real surfaces are reviewed. The intrinsic contact angle is discussed in terms of the Young equation and the line tension concept. The fundamental question that is presented and discussed is the relationship between the intrinsic, actual and apparent contact angles. Apparent contact angle measurement using the Capillary Bridge System (CBS) is explained. The main advantages of this approach are the use of force measurements rather than direct optical measurements, and the ability to calculate an average apparent contact angle. The Wenzel equation for rough surfaces and the Cassie equation for heterogeneous surfaces are shown to be true only for drops that are very large compared to the scale of roughness/heterogeneity. Contact angle hysteresis is explained. Of special interest is the predicted difference between the drop and captive bubble techniques, which stems from contact angle hysteresis.
Amateur porn in Filipino Twitter alter community: affordances, commodification, ghettoization, and gay masculinity

This research tackles the alter community or a collective of Filipino Twitter users producing and circulating amateur porn in the form of videos or text. This article analyzes the ways in which Twitter’s features and user practices enable and constrain the production and circulation of porn, as well as its implication in understanding gay masculinity and sexual politics. By looking at Twitter’s affordances and the dynamics in the alter community, I argue that the alter community is a site where Filipino perform and validate their masculinity. This takes place alongside commodification and ghettoization that fits neatly into restraining attitudes on sexuality in the Philippines. This article contributes to a more complex and nuanced understanding of pornography, as well as the ways in which technological affordances and dynamics in distinct virtual spaces impact our understanding of gay masculinities.
Diverse Regional Sensitivity of Summer Precipitation in East Asia to Ice Volume, CO2 and Astronomical Forcing

The relative influence of insolation, CO2, and ice sheets on the East Asian summer monsoon (EASM) is not well understood especially at regional scale. Here a Gaussian emulator based on simulations with HadCM3 is used to quantitatively assess how astronomical forcing, CO2, and northern hemisphere ice sheets affect the variation of the summer precipitation over the last 800 ky. Our results show that in the EASM domain north of 25°N, the variation of the summer precipitation is dominated by precession, leading to strong 23‐ky cycles, while the ice sheets only modulate the effect of insolation by influencing the land‐sea pressure gradient. In the southern part, ice sheets play a more important role, generating 100‐ky cycles, through influencing the latitude of the Intertropical Convergence Zone and the Hadley cell. Obliquity and CO2 have little effect on the summer precipitation as compared to precession and ice sheets.
Effects of Thermochemical Treatment on CuSbS2 Photovoltaic Absorber Quality and Solar Cell Reproducibility

CuSbS2 is a promising nontoxic and earth-abundant photovoltaic absorber that is chemically simpler than the widely studied Cu2ZnSnS4. However, CuSbS2 photovoltaic (PV) devices currently have relatively low efficiency and poor reproducibility, often due to suboptimal material quality and insufficient optoelectronic properties. To address these issues, here we develop a thermochemical treatment (TT) for CuSbS2 thin films, which consists of annealing in Sb2S3 vapor followed by a selective KOH surface chemical etch. The annealed CuSbS2 films show improved structural quality and optoelectronic properties, such as stronger band-edge photoluminescence and longer photoexcited carrier lifetime. These improvements also lead to more reproducible CuSbS2 PV devices, with performance currently limited by a large cliff-type interface band offset with CdS contact. Overall, these results point to the potential avenues to further increase the performance of CuSbS2 thin film solar cell, and the findings can be transferred t.
Impact of Application of Nursing Guidelines on Health Outcomes for Patients Undergoing Gastrointestinal Endoscopes

Background: Endoscopy is a nonsurgical procedure used to examine a person's digestive tract. Using an endoscope, a flexible tube with a light and camera attached to it, the doctor can view pictures of the digestive tract on a color TV monitor. Aim of this study was to evaluate impact of application of nursing guidelines on health outcomes for patients undergoing gastrointestinal endoscopes. Subjects and methods: A quasi-experimental research design was used. A convenient sample was used; it includes all nursing staff working with patient undergoing GI endoscopy (40 nurses) and 240 adult patients. This study conducted at GI endoscopy unit at Al-Azhar University Hospital at new Damietta city. Three tools used for data collection . Tool (1) is a pre/post-patient structured interview. Tool (2) is a pre \ post nurse structured interview. Tool (3) is an observational check list for nurses’ practice. Results , show a significant improvement in the nurses' knowledge and practice scores after nursing guidelines implementation regarding the care of patients with GIT endoscopy at (p- value = 0.00, 0.02 & 0.04) respectively. Positive significant correlation between nurses’ knowledge and practice before and after guidelines implementation in the following items (general preparation - pre-procedure) post procedure items and total practice score. Conclusion , there was significant improvement in nurse's knowledge and practice about care of patients undergoing GI endoscopy after implementation of nursing guidelines. As well as improving patient outcomes . The study recommended that Continuous and adequate education and training of nursing staff working at gastrointestinal endoscopy units with regular and continuous evaluation of nurses' practice.