Miracle-dz/UniFAR-FTUs huggingface dataset:
causal relationship model of green logistics management and lean management affecting food and beverage industrial performance in Thailand

This research aims to study the effect of green logistics management and lean management on environmental performance and industrial performance of food and beverage industry in Thailand. The research was designed as quantitative. The sample consisted of 430 food and beverage enterprises in Thailand. Data were analyzed using structural equation modelling (SEM) technique. The findings revealed that green logistics management and lean management influence environmental performance and industrial performance of the food and beverage industry in Thailand at a statistical significance level of 0.05 with the statistical values of c2= 99.472, df = 83, p-value = 0.105, c2/df = 1.198, RMSEA = 0.022, RMR = 0.009, GFI = 0.976, AGFI = 0.945, CFI = 0.998, which can predict 77.80% of industrial performance. This indicates that that green logistics management and lean management can help improve performance of organizations and industries, enabling them to compete and survive in a dynamic business environment. Not only do green logistics management and lean management help improve financial performance, but they also help protect the environment, leading organizations to develop sustainable growth.
Solar drying of mushroom using solar tunnel dryer

Solar drying of Mushroom was conducted to investigate the performance of the solar tunnel dryer for drying mushrooms. The dryer consists of a transparent UV stabilized plastic covered flat plate collector and drying tunnel unit. The drier is arranged to supply hot air directly into the drying tunnel using three dc fans powered by a 40 watt solar module. The products to be dried are placed in a single layer on a wire mesh in the drying tunnel to receive energy from both hot air supplied from the collector and from the incident solar radiation on products. During the experimental period the minimum and maximum solar radiation were 273 W/m² and 885 W/m² respectively. The generated voltages for the 40 W solar modules were 4.5. V to 14.8 V. Temperatures in the drying chamber varied from 37.0° C to 66.5° C. Mushrooms were dried from about 89.41% to 6.14% moisture content (w.b) in about 8 hours. In the same drying period, the moisture content of mushrooms reduced from 89.41% to15% in the traditional sun drying method. In addition, the Mushroom being dried in the solar tunnel drier were completely protected from rain, insects and dust, and the dried mushrooms were high quality dried products terms of flavor, color and texture. As the fans are powered by a solar module, the drier could be used in rural areas where there is no supply of electricity from grid.
The genetics of adaptation in freshwater Eurasian shad (Alosa)

Abstract Studying the genetics of phenotypic convergence can yield important insights into adaptive evolution. Here, we conducted a comparative genomic study of four lineages (species and subspecies) of anadromous shad (Alosa) that have independently evolved life cycles entirely completed in freshwater. Three naturally diverged (A. fallax lacustris, A. f. killarnensis, and A. macedonica), and the fourth (A. alosa) was artificially landlocked during the last century. To conduct this analysis, we assembled and annotated a draft of the A. alosa genome and generated whole‐genome sequencing for 16 anadromous and freshwater populations of shad. Widespread evidence for parallel genetic changes in freshwater populations within lineages was found. In freshwater A. alosa, which have only been diverging for tens of generations, this shows that parallel adaptive evolution can rapidly occur. However, parallel genetic changes across lineages were comparatively rare. The degree of genetic parallelism was not strongly related to the number of shared polymorphisms between lineages, thus suggesting that other factors such as divergence among ancestral populations or environmental variation may influence genetic parallelism across these lineages. These overall patterns were exemplified by genetic differentiation involving a paralog of ATPase‐α1 that appears to be under selection in just two of the more distantly related lineages studied, A. f. lacustris and A. alosa. Our findings provide insights into the genetic architecture of adaptation and parallel evolution along a continuum of population divergence.
Histopathological Analysis of the Effect of Photodynamic Action on Post-Chemotherapy Excised Breast Cancer Tissue

Background and objectives: Breast cancer is the most commonly diagnosed cancer in women and its mortality is increasing. Therefore, research to improve treatment is of paramount importance. One method of treatment is photodynamic therapy. Photodynamic therapy selectively stimulates apoptosis in photosensitizer-treated neoplastic breast cells as a result of cytotoxic singlet oxygen generation via collisions between triplet excited state photosensitizer and triplet ground state oxygen upon tissue irradiation. The aim of this study was to evaluate the effects of photodynamic action on cancerous breast tissue samples as a model of photodynamic therapy. Materials and Methods: Breast cancer tissue samples were obtained from post-operative material and the patterns of histopathological changes in breast cancer tissue before and after photodynamic action on post-chemotherapy tissue were evaluated. Excised tissue samples were obtained from 48 female breast cancer patients who had previously undergone chemotherapy. Breast cancer tissues for this study were taken from macroscopically visible tumors larger than 10 mm. Histopathological analysis was performed to evaluate any morphological changes prior to and after photodynamic action on the post-chemotherapy tissue samples. Eighteen breast cancer tissue samples were analyzed before chemotherapy, fifteen after chemotherapy, and fifteen samples were analyzed after chemotherapy and application of photodynamic action. The photosensitizer Rose Bengal was applied to the samples subjected to photodynamic action. Results: Photodynamic action on post-chemotherapy neoplastic tissue showed histological changes under a light microscope. The results showed that morphological changes in breast cancer tissues after chemotherapy and photodynamic action were dependent on the concentration of Rose Bengal. In all cases, follow-up imaging showed tumor shrinkage of an average of 35% from baseline size. Conclusions: Histopathological examination revealed photosensitizer-concentration-dependent changes after photodynamic action in excised post-chemotherapy tissue. The effects of photodynamic action observed in this study suggest that the application of photodynamic therapy after chemotherapy can aid in breast cancer cell eradication.
Glycome Profiling of Cancer Cell Lines Cultivated in Physiological and Commercial Media

A complex physiological culture medium (Plasmax) was introduced recently, composed of nutrients and metabolites at concentrations normally found in human plasma to mimic the in vivo environment for cell line cultivation. As glycosylation has been proved to be involved in cancer development, it is necessary to investigate the glycan expression changes in media with different nutrients. In this study, a breast cancer cell line, MDA-MB-231BR, and a brain cancer cell line, CRL-1620, were cultivated in Plasmax and commercial media to reveal cell line glycosylation discrepancies prompted by nutritional environments. Glycomics analyses of cell lines were performed using LC-MS/MS. The expressions of multiple fucosylated N-glycans, such as HexNAc4Hex3DeoxyHex1 and HexNAc5Hex3DeoxyHex1, derived from both cell lines exhibited a significant increase in Plasmax. Among the O-glycans, significant differences were also observed. Both cell lines cultivated in EMEM had the lowest amounts of O-glycans expressed. The original work described the development of Plasmax, which improves colony formation, and resulted in transcriptomic and metabolomic alterations of cancer cell lines, while our results indicate that Plasmax can significantly impact protein glycosylation. This study also provides information to guide the selection of media for in vitro cancer cell glycomics studies.
A Self Training Mechanism With Scanty and Incompletely Annotated Samples for Learning‐Based Cloud Detection in Whole Sky Images

Cloud detection is one of important tasks in automatic ground‐based cloud observation systems with ground‐based cloud images. Most supervised methods need substantial annotated samples for model training, while the pixel‐level annotation costs a lot. In this letter, a self‐training mechanism is proposed to significantly reduce the requirement of annotated samples. With a number of original images, only a few images need to be annotated (even incompletely), and a local region classifier model can be initialized with the annotated samples. Then the model is retrained iteratively using unlabeled samples with high confidence pseudo labels given by a fusion decision. The finely trained model can classify the local regions into “cloud” or “sky”. The experiments show that the proposed mechanism is effective for several classifiers. The proposed method can outperform unsupervised methods and achieve comparable results with fully supervised learning methods but using much fewer annotated samples.
Laboratory variables as predictors of progression in gastroenteropancreatic neuroendocrine tumors in different lines of antineoplastic treatments

ABSTRACT Objective: To determine the association of red cell blood counts, and liver panel tests to predict outcomes in patients with gastroenteropancreatic neuroendocrine tumors who underwent systemic antineoplastic treatments. Methods: Patients with gastroenteropancreatic neuroendocrine tumors in systemic treatment were assessed according to laboratory tests within the same period. Progression free survival was determined by the period between the beginning of treatment and the date of progression. We used conditional models (PWP model) to verify the association between laboratory tests and tumor progression. The level of significance used was 5%. Results: A total of 30 treatments given to 17 patients in the intention-to-treat population were evaluated. Treatment included octreotide, lanreotide, everolimus, lutetium, and chemotherapy. We had statistically significant results in chromogranin A, neutrophils and platelets-to-lymphocyte ratio. The risk of progression increases by 2% with the addition of 100ng/mL of chromogranin A (p=0.034), 4% with the increase of 100 neutrophil units (p=0.006), and 21% with the addition of 10 units in platelets-to-lymphocyte ratio (p=0.002). Conclusion: Chromogranin A, neutrophils and platelets-to-lymphocyte ratio were associated with disease progression during systemic treatment in gastroenteropancreatic neuroendocrine tumors. Further prospective studies with larger cohorts are necessary to validate our findings.
Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse

Cystathionine beta synthase (CBS) catalyzes the first step of the transsulfuration pathway from homocysteine to cystathionine, and its deficiency leads to hyperhomocysteinemia (HHcy) in humans and rodents. To date, scarce information is available about the HHcy effect on insulin secretion, and the link between CBS activity and the setting of type 2 diabetes is still unknown. We aimed to decipher the consequences of an inborn defect in CBS on glucose homeostasis in mice. We used a mouse model heterozygous for CBS (CBS+/−) that presented a mild HHcy. Other groups were supplemented with methionine in drinking water to increase the mild to intermediate HHcy, and were submitted to a high-fat diet (HFD). We measured the food intake, body weight gain, body composition, glucose homeostasis, plasma homocysteine level, and CBS activity. We evidenced a defect in the stimulated insulin secretion in CBS+/− mice with mild and intermediate HHcy, while mice with intermediate HHcy under HFD presented an improvement in insulin sensitivity that compensated for the decreased insulin secretion and permitted them to maintain a glucose tolerance similar to the CBS+/+ mice. Islets isolated from CBS+/− mice maintained their ability to respond to the elevated glucose levels, and we showed that a lower parasympathetic tone could, at least in part, be responsible for the insulin secretion defect. Our results emphasize the important role of Hcy metabolic enzymes in insulin secretion and overall glucose homeostasis.
Self-Reported Long-Term Implications of a Marathon Training Program for Adolescents: A Qualitative Study

This project helped to gain a deeper understanding of the long-term effects of a community-based marathon training on physical activity levels, psychological health status, character development, and positive health habit behaviors in young adults who completed the program during their adolescence. Participants completed open-ended questionnaires via a secure data collection system. Answers were transcribed and thematic content was described using rigorous analysis. The long-term goals of the marathon training program including improvement in physical health, improvement in psychological health, development of personal character, and promotion of healthy good habits into adulthood were present in the majority of the young adult participants. Participants specifically cited experiences from this training program as informing their current ability to engage and maintain healthy lifestyle choices. This marathon-training program potentially instilled long-term positive outcomes in these young adult respondents following their participation during adolescence, which enabled them to engage in and sustain healthy lifestyles in the years following completion of the program.
CRISPR/Cas9-Mediated Disruption of the lef8 and lef9 to Inhibit Nucleopolyhedrovirus Replication in Silkworms

Bombyx mori nucleopolyhedrovirus (BmNPV) is a pathogen that causes severe disease in silkworms. In a previous study, we demonstrated that by using the CRISPR/Cas9 system to disrupt the BmNPV ie-1 and me53 genes, transgenic silkworms showed resistance to BmNPV infection. Here, we used the same strategy to simultaneously target lef8 and lef9, which are essential for BmNPV replication. A PCR assay confirmed that double-stranded breaks were induced in viral DNA at targeted sequences in BmNPV-infected transgenic silkworms that expressed small guide RNAs (sgRNAs) and Cas9. Bioassays and qPCR showed that replication of BmNPV and mortality were significantly reduced in the transgenic silkworms in comparison with the control groups. Microscopy showed degradation of midgut cells in the BmNPV-infected wild type silkworms, but not in the transgenic silkworms. These results demonstrated that transgenic silkworms using the CRISPR/Cas9 system to disrupt BmNPV lef8 and lef9 genes could successfully prevent BmNPV infection. Our research not only provides more alternative targets for the CRISPR antiviral system, but also aims to provide new ideas for the application of virus infection research and the control of insect pests.
GeneXpert MTB/RIF combined with conventional methods for tuberculosis in Shanghai Regional Medical Center: a retrospective diagnostic study

Background At present, the diagnosis of tuberculosis (TB) is still challenging, and improving the efficiency of diagnosis can help prevent and control TB. This retrospective clinical study aimed to assess the diagnostic efficiency of GeneXpert MTB/RIF for pulmonary TB. Methods A total of 620 newly-diagnosed patients who visited the pulmonary clinic of Shanghai Tongren Hospital between 2018 and 2021 were enrolled in the study. All 620 patients had acid-fast Bacilli (AFB) identified by Ziehl Neelsen staining (ZNS) test, BECTEC MGIT 960 liquid culture (LC), and GeneXpert MTB/RIF assay (GX). A total of 53 patients also underwent interferon-γ release assay (IGRA). The diagnostic efficacy of ZNS, LC, GX alone or in combination in pulmonary TB was evaluated, with clinical diagnosis as the gold standard. Moreover, the IGRA for pulmonary TB diagnosis was preliminarily assessed. Results Eventually, 185 cases were clinically confirmed (which included 36 etiologically negative cases) in the total enrolled 620 first-diagnosed patients. Overall, the 3 methods ZNS, LC, and GX showed sensitivities of 55.68%, 64.32%, and 68.64%, specificities of 98.39%, 95.40%, and 99.08%, positive predictive values (PPV) of 93.64%, 85.61%, and 96.95%, and negative predictive values (NPV) of 83.92%, 86.28%, and 88.14%, respectively. The GX method showed the highest specificity and PPV for a solitary single method, with 99.08% and 96.95%, respectively. Regarding pairwise combination methods, all showed superior sensitivity to a single test, reaching a maximum of 80.00%. Among them, the LC + GX combination showed both the highest sensitivity (80.00%) and NPV (91.78%), and the corresponding area under the receiver operating characteristic curve (0.875) was the largest. Among the 53 patients who underwent IGRA testing, 42 were positive (including 4 etiologically negative cases), and 11 were negative. The overall sensitivity of IGRA for diagnosing pulmonary TB was 90.00%, specificity was 27.27%, PPV was 42.86%, and NPV was 81.82%. Conclusions The GX method shows promise as a first-line diagnostic method for pulmonary TB. Furthermore, the sensitivity was significantly improved when combined with LC. This combination will screen out some etiologically negative patients plus IGRA, so their combination is recommended for practice optimization.
Long-Term Survival Following Minimally Invasive Lung Cancer Surgery: Comparing Robotic-Assisted and Video-Assisted Surgery

Simple Summary Video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracoscopic surgery (RATS) are known to be safe and efficient surgical procedures to treat lung cancer. Both VATS and RATS allow anatomical resection associated with radical lymph node dissection. However, RATS, unlike VATS, allows the thoracic surgeon to mimic an open approach and to perform lung resection. We hypothesized that the technical advantages of RATS, compared with VATS, would allow more precise resection, with “better lymph node dissection” which could increase survival compared to VATS. Nevertheless, VATS, and RATS nodal up-staging are still debated, with conflicting results and in our study, as well as in the medical literature, RATS failed to show its superiority over VATS in resectable non-small cell lung cancer. Abstract Background: Nowadays, video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracoscopic surgery (RATS) are known to be safe and efficient surgical procedures to treat early-stage non-small cell lung cancer (NSCLC). We assessed whether RATS increased disease-free survival (DFS) compared with VATS for lobectomy and segmentectomy. Methods: This retrospective cohort study included patients treated for resectable NSCLC performed by RATS or VATS, in our tertiary care center from 2012 to 2019. Patients’ data were prospectively recorded and reviewed in the French EPITHOR database. Primary outcomes were 5-year DFS for lobectomy and 3-year DFS for segmentectomy, compared by propensity-score adjusted difference of Kaplan–Meier estimates. Results: Among 844 lung resections, 436 VATS and 234 RATS lobectomies and 46 VATS and 128 RATS segmentectomies were performed. For lobectomy, the adjusted 5-year DFS was 60.9% (95% confidence interval (CI) 52.9–68.8%) for VATS and 52.7% (95%CI 41.7–63.7%) for RATS, with a difference estimated at −8.3% (−22.2–+4.9%, p = 0.24). For segmentectomy, the adjusted 3-year DFS was 84.6% (95%CI 69.8–99.0%) for VATS and 72.9% (95%CI 50.6–92.4%) for RATS, with a difference estimated at −11.7% (−38.7–+7.8%, p = 0.21). Conclusions: RATS failed to show its superiority over VATS for resectable NSCLC.
Lack of Monitoring Is Associated with Risk of Acute Kidney Events among Patients with Inflammatory Bowel Disease

Background: Although the iatrogenic risk of kidney failure is infrequent with treatment for inflammatory bowel disease (IBD), the repercussions for the patient could be major. The aim of this study was to assess the incidence of kidney events in IBD and to examine the protective effect of kidney function monitoring. Methods: In the French National Health Insurance database, 94,363 patients had a diagnosis of IBD between January 2010 and December 2016. By using a survival model with time-dependent covariates, we analyzed the time from inclusion in this IBD cohort to the first hospitalization for acute kidney impairment (AKI) according to patient characteristics, comorbidities, IBD phenotype and presence of monitoring. Results: A total of 693 patients were hospitalized for AKI, with an incidence of 1.36/1000 person–years (95% confidence interval [CI] 1.26–1.47). The incidence of AKI was lower than those without 5-aminosalicylic acid (5-ASA) use. Patients with 5-ASA use rarely had any lack of monitoring as compared with those not under 5-ASA use (3% vs. 17%). On multivariate analysis, lack of monitoring was associated with a substantial risk of AKI (hazard ratio 3.96, 95% CI [3.20–4.90], p < 0.0001). Conclusions: Increased frequency of monitoring is essential to identify nephropathy at an early stage and avoid the progression to chronic kidney disease.
Stability and convergence in case marking

In Modern Low German, there are signs for a newly emerging dative caseunder Standard German influence. The present paper analyzes this case ofpotential convergence, concentrating on definite articles of neuter gender.Methodologically, a new corpus of spontaneous speech is used, alongside theestablished Zwirner corpus from the middle of the last century. It turns outthat full forms of the definite article are rather stable – they retain the old LowGerman two-way case system and thus defy convergence. Reduced forms, onthe other hand, do converge towards Standard German. Here, distinct dativeforms are dominant. This is in line with older findings about the decline of theold dative case in Middle Low German.