Miracle-dz/UniFAR-FTUs huggingface dataset:
T + CD4Expression Leads to a Strong Th2 Bias in Deregulated MHC Class II Transactivator

The MHC class II (MHC-II) transactivator (CIITA) is the master transcriptional regulator of genes involved in MHC-II-restricted Ag presentation. Fine tuning of CIITA gene expression determines the cell type-speciﬁc expression of MHC-II genes. This regulation is achieved by the selective usage of multiple CIITA promoters. It has recently been suggested that CIITA also contributes to Th cell differentiation by suppressing IL-4 expression in Th1 cells. In this study, we show that endogenous CIITA is expressed at low levels in activated mouse T cells. Importantly CIITA is not regulated differentially in murine and human Th1 and Th2 cells. Ectopic expression of a CIITA transgene in multiple mouse cell types including T cells, does not interfere with normal development of CD4 (cid:1) T cells. However, upon TCR activation the CIITA transgenic CD4 (cid:1) T cells preferentially differentiate into IL-4-secreting Th2-type cells. These results imply that CIITA is not a direct Th1-speciﬁc repressor of the IL-4 gene and that tight control over the expression of CIITA and MHC-II is required to maintain the normal balance between Th1 and Th2 responses. The Journal of Immunology, 2003, 170: 1150–1157. and
Does disturbance history affect the resistance and resilience of bacterial communities?

Bacterial communities play a central role in ecosystems and studying their resistance and resilience provides an important step towards predicting the response of microbial ecosystems to environmental disturbances. Since natural communities undergo regular disturbances and incidences of extremes in environmental conditions, communities may ‘accumulate’ a disturbance history over time. It is generally assumed that recurring disturbances increase resistance and resilience through selection processes, but on the other hand too many disturbances may result in more vulnerable communities and slow down community recovery. Moreover, any change in resistance and resilience due to adaptation might be specific to the type of disturbance that caused the selection pressure, or confer a more general advantage in the face of a broad range of disturbances. Here we hypothesize that (a) resistance and resilience of bacterial communities increases over time when communities are exposed to recurring disturbances and (b) that communities with a history of frequent exposure to strong disturbances of one type, will be less sensitive and more resilient to a novel type of disturbance. In order to test these hypotheses, natural lake bacterioplankton communities were subjected to weekly temperature shocks of two different intensities for four weeks, and subsequently exposed to an acidification event. Throughout the experiment bacterial abundance and bacterial production were measured daily, whereas enzyme activities and bacterial community composition were determined every week. The results from these experiments indicated that exposure to repeated temperature disturbances can increase the resistance and resilience of microbial communities, but it depends on the parameter that is measured. Additionally, the history of temperature disturbances had a clear effect on the ability of the communities to deal with an acidification event, but again it depended on the parameter that was measured whether it had a positive or negative effect on the measured parameter. The community composition was mainly affected by the temperature disturbances and not by the acidification, suggesting possible importance of time lags as well as similarity in the stress tolerance mechanisms that were selected for by the disturbances.
THE PRESENT SITUATION IN QUANTUM MECHANICS: A TRANSLATION OF SCHR6DINGER'S "CAT PARADOX" PAPER

This is a translation of Schr6dinger's three-part 1935 paper 1 in Die Naturzkissenschaften. Earlier that same year there had appeared the Einstein, Podolsky, Rosen paper 2 (also famous in "paradoxology") which, Schrodinger says, in a footnote, motivated his offering. Along with this article in German, Schrodinger had two closely related English-language publications.3 But the German, aside from its oneparagraph presentation of the famous cat, covers additional territory and gives many fascinating insights into Schrodinger's thought. The translator's goal has been to adhere to the logical and physical content of the original, while at the same time trying to convey something of its semi-conversational, at times slightly sardonic flavor.
Extraction of maxillary root stumps using reflect- A modified mouth mirror

Maxillary root stumps are challenging to extract as they can only be viewed by indirect vision and blood oozing out of the socket obstructs the vision. To overcome these problems reflect was invented, it has anti-fogging property and also has a led light for vision. A cross sectional questionnaire was distributed to 9 post graduates in the oral surgery department of Saveetha dental college with the mirror and results were analysed. It was concluded that extraction of maxillary root stumps is easier using reflect.
PERCEPTION OF GEMBA KAIZEN’S UPPER MANAGEMENT COMMITMENT PRINCIPLE ON EMPLOYEE PERFORMANCE IN KENYA

Harnessing human capital and converting it into useful industrial processes can best be realized through competent management systems. However, without significant commitment from the upper management as espoused in the Gemba Kaizen principles, strategies to improve employee performance may fall short of their objectives. Gemba Kaizen principles have been adopted in several private and public sector organizations globally, and the upper management commitment principle is being subsequently practiced in the organizations. However, the influence of the application of the Gemba Kaizen upper management commitment principle on employee performance has not received significant research attention previously. Therefore, the objective of this study was to examine the application of GembaKaizen’supper management commitment principle on employee performance in Kenya Wildlife Service, Tsavo East National Park, Kenya. The study adopted a descriptive research design targeting employees of Kenya Wildlife Service, Tsavo East National Park. Data collected through pre-tested copies of questionnaire from 202 respondentsrevealed that the Gemba Kaizenupper management commitment principlesignificantly influenced employee performance in the Kenya Wildlife Service. There was a significant linear relationship between the Kaizen Principle of upper management commitment and employees’ understanding the contribution of their role in performance of the organization. Employees increase their outputs if the top management is committed by communicating the importance of meeting regulatory requirements, establishing the quality policy, ensuring that quality objectives are established, conducting management reviews and ensuring the availability of resources. It is, therefore, recommended that the upper management in the Kenya Wildlife Service begin inculcating the need for team effort and customer satisfaction among employees for the achievement of organizational objectives.
Travaux de Herman sur les tores invariants

© Société mathématique de France, 1992, tous droits réservés. L’accès aux archives de la collection « Astérisque » (http://smf4.emath.fr/ Publications/Asterisque/) implique l’accord avec les conditions générales d’utilisation (http://www.numdam.org/conditions). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.
POSTERIOR SEGMENT OPHTHALMIC MALFORMATIONS: HISTOPATHOLOGICAL SPECTRUM CORRELATED TO CLINICAL PRESENTATION AND REVIEW OF THE LITERATURE

: Purpose: A wide range of posterior ophthalmic malformation is undervalued in the literature. This includes congenital cystic eye, microphthalmia and anophthalmia, Persistent Hyperplastic Primary Vitreous, and other retina disc anomalies. Moreover, there is a lack of regional data in the kingdom of Saudi Arabia regarding these anomalies. In this sense, the current study consists of a literature review and a case series of posterior ophthalmic malformation to see if there is any difference in the spectrum of pathology presentation in KSA compared to other regions. Methods: Retrospective study reviewing medical records and histopathology finding looking for the spectrum of disease and presentation for patients with posterior ophthalmic malformations in King Abdulaziz University Hospital [KAUH] and King Khaled Eye Specialist Hospital [KKESH] from the period of [2000-2018]. Results: Total of seven out of twelve histopathologically confirmed cases of posterior ophthalmic malformation were included in this study. Charts revealed that most cases were females, and all of them presented unilateral anomalies. Family history, due to the high consanguinity rate in the studied population, revealed only one case of a patient with parents who were first degree relatives. Conclusion: The current work adds a proper understanding of posterior ocular malformation pathological spectrum, together with the outcomes in KSA population to provide a better management and counseling.
Study of hadronic final states from double tagged gammagamma events at LEP

The interaction of virtual photons is investigated using double tagged gammagamma events with hadronic final states recorded by the ALEPH experiment at e^+e^- centre-of-mass energies between 188 and 209 GeV. The measured cross section is compared to Monte Carlo models, and to next-to-leading-order QCD and BFKL calculations.
Narrative Approach in the Investigation of Learning Mediated by ePortfolio

The aim of this article is to present and discuss a narrative approach to the investigation of learning mediated by ePortfolio. It is a qualitative study within nursing education. The method was inspired by the French philosopher, Paul Ricoeur, with focus on Ricoeur’s theory of narrative and interpretation. Data were generated through participant observations, narratives and portfolio documents. The discussion revolves around the extent to which the method was effective in the generation of data, how the data were interpreted, and how the study contributed to the discourse on learning in clinical settings. The principal conclusion is that the method was practicable for the generation and interpretation of data. Thus, the study contributed to a more detailed understanding of learning in nursing education, especially as regards the discourse on learning in clinical settings.
Observation of Associated Near-Side and Away-Side Long-Range Correlations in ¼ 5 : 02 TeV Proton-Lead Collisions with the ATLAS Detector

Two-particle correlations in relative azimuthal angle ( (cid:1) (cid:1) ) and pseudorapidity ( (cid:1) (cid:2) ) are measured in ﬃﬃﬃﬃﬃﬃﬃﬃ s NN p ¼ 5 : 02 TeV p þ Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 (cid:3) b (cid:1) 1 of data as a function of transverse momentum ( p T ) and the transverse energy ( (cid:2) E PbT ) summed over 3 : 1 < (cid:2) < 4 : 9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range ( 2 < j (cid:1) (cid:2) j < 5 ) ‘‘near-side’’ ( (cid:1) (cid:1) (cid:2) 0 ) correlation that grows rapidly with increasing (cid:2) E PbT . A long-range ‘‘away-side’’ ( (cid:1) (cid:1) (cid:2) (cid:4) ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small (cid:2) E PbT , is found to match the near-side correlation in magnitude, shape (in (cid:1) (cid:2) and (cid:1) (cid:1) ) and (cid:2) E PbT dependence. The resultant (cid:1) (cid:1) correlation is approximately symmetric about (cid:4)= 2 , and is consistent with a dominant cos2(cid:1) (cid:1) modulation for all (cid:2) E PbT ranges and particle p T . Proton-nucleus ( p þ A ) collisions at the Large Hadron
PhenotypeSubset and Persist with a Variable CD45 Are Detectable in the CD8 and not the CD4 Clonal Expansions in Acute EBV Infection

We have applied a sensitive global analysis of TCR heterogeneity to compare clonal dynamics of CD4 1 and CD8 1 T cells in acute infectious mononucleosis. Using this approach, we are able to identify a broad representation of the total virus-speciﬁc population without the bias of in vitro culture and then to track their phenotype and fate by their unique molecular footprint. We demonstrate a large number of Ag-driven clones using different TCRs in the acute phase, all CD8 1 . The diverse large clones generated in the CD8 subset in response to this virus contrast with the complete lack of detectable clonal expansion in the CD4 compartment. Many of the same clones remain detectable in directly ex vivo CD8 1 T cells for at least a year after resolution of infectious mononucleosis, although the clone size is reduced. Thus, memory CD8 cells following EBV infection persist at relatively high circulating frequency and represent a subset of the large range of clonotypes comprising the acute effectors. Separation of samples into CD45RA (naive) and CD45RO (memory) fractions shows the accumulation of identical CDR3 region deﬁned clonotypes in both CD45RO and CD45RA fractions and sequencing conﬁrms that dominant long-lived monoclonal expansions can reside in the CD45RA pool. The Journal of Immunology, 2000, 165: 5729–5737. surprisingly high circulating frequencies following disease resolution. The data indicate that a relatively heterogeneous repertoire
Using Multitasking and SSD Disks for Optimising Computing Cluster Energy-Efﬁciency

—We tested how solid-state drives (SSD) and multi-tasking, i.e., running more than one task per CPU core, affect performance and energy consumption in I/O intensive data analysis jobs in high-energy physics (HEP) computing. Our motivation for the study comes from the LHC experiment at CERN producing up to 15 petabytes of data annually. The data is analysed by a huge grid computing infrastructure containing more than 100 000 CPU cores over 140 computing centres in different countries. Our tests indicated that in I/O intensive HEP computing multitasking, mixing heterogeneous tasks, and using SSD disks can clearly improve throughput and lower energy consumption. The throughput improved around 120% and energy consumption decreased around 50% compared to a conventional one task per CPU core setting with a hard disk system.
Nonlinear Dynamic Motivation, Demotivation, Self-Efficacy Anxiety and Psychological Reactance via SEM in CALL Context

Testing a theoretical model that subsumes the individual and collective relationship of motivation, demotivation, self-efficacy and anxiety on psychological reactance (PR) while highlighting their nonlinear and dynamic nature in language learning and language learner, was the goal of the study. Structural equation modeling was run by AMOS version 16.0, to analyze the proposed model in second language (L2) learning in computer assisted language learning (CALL) context with a focus on nonlinearity and dynamicity as integral features. The model asserts that at least part of the effect of nonlinear dynamic motivation (NDM) on PR is that it reduces PR at three behavioral forms: incivility, resistance, and dissent. Accordingly, NDM influences learner self-efficacy, which in return reduces PR. The model also asserts that at least part of the effect of nonlinear dynamic demotivation (NDD) on PR is that it increases PR at three behavioral forms: incivility, resistance, and dissent. It was revealed that NDD affects learner anxiety and learner anxiety in return increases PR. The main pedagogical implication is the need to address the nonlinearity and dynamicity of motivation which will not only reduce demotivation and learner anxiety, but will also reduce PR as the main source of oppositional behavior in L2 learning context.
CMAR_A_265756 8787..8799

1Departments of Ultrasound, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, People’s Republic of China; 2Departments of General Surgery, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, People’s Republic of China; 3Departments of Pathology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, People’s Republic of China
ZIMMERMANN-SUGARS IN EXUDATE OF TREES

10. PARTRIDGE, S. M. Partition chromatography and its application to carbohydrate studies. Biochem. Soc. Symposia (Cambridge, Engl.) No. 3: 52-61. 1949. 11. WXANNER, H. Die Zusammensetzung des Siebr6hensaftes: Kohlenhydrate. Ber. schweiz. bot. Ges. 63: 162-168. 1953. 12. WILD, G. M. and FRENCH, D. The galactan series of oligosaccharides. Proc. Iowa Acad. Sci. 59: 226-230. 1952. 13. ZIEGLER, H. Untersuchungen uiber die Leitung und Sekretion der Assimilate. Planta 47: 447-500. 1956.
COPD_A_255414 1729..1738

Konstantinos Kostikas 1 David Price 2 Florian S Gutzwiller 3 Bethan Jones 4 Emil Loefroth Andreas Clemens 3,5 Robert Fogel 6 Rupert Jones 7 Hui Cao 1Respiratory Medicine Department, University Hospital of Ioannina, Ioannina, Greece; 2Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK; 3Novartis Pharma AG, Basel, Switzerland; 4Pharmatelligence, Cardiff, UK; 5Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany; 6Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; 7Plymouth University Peninsula School of Medicine and Dentistry, Plymouth, UK Purpose: Previous studies have shown that opportunities to diagnose chronic obstructive pulmonary disease (COPD) early are often missed in primary care. This retrospective study aimed to utilize secondary data from the United Kingdom (UK) healthcare system to understand the impact of early versus late diagnosis of COPD. Patients and Methods: Newly diagnosed COPD patients were identified in the UK Clinical Practice Research Database from 2011 to 2014. Patients whose 5-year medical data before diagnosis revealed ≥3 counts of eight indicators of early COPD were deemed as late-diagnosed, whereas others were deemed as early-diagnosed. We assessed patients’ characteristics; time-tofirst, risk, and rates of exacerbation; and healthcare resource utilization (COPD-related clinic visits, Accident and Emergency visits, and hospitalizations) in lateversus early-diagnosed patients. Results: Of 10,158 patients included in the study, 6783 (67%) were identified as latediagnosed and 3375 (33%) as early-diagnosed. The median time-to-first exacerbation was shorter in late-diagnosed (14.5 months) versus early-diagnosed (29.0 months) patients, with a significant risk of exacerbation (hazard ratio 1.46 [95% confidence interval: 1.38–1.55]). Additionally, the exacerbation rate (per 100 person-years) over 3 years was higher in late (108.9) versus early (57.2) diagnosed patients. Late-diagnosed patients had a significantly higher rate of COPD hospitalizations (per 1000 patient years) compared with early-diagnosed patients during 2 and 3 years of follow-ups (P = 0.0165 and P < 0.0001, respectively). Conclusion: Results showed that a significant percentage of COPD patients in UK primary care are diagnosed late. A late COPD diagnosis is associated with a shorter time-to-first exacerbation and a higher rate and risk of exacerbations compared with early diagnosis. Additionally, late diagnosis of COPD is associated with a higher rate of COPD-related hospitalizations compared with early diagnosis.
Experimental Hepatitis Attenuator in NKT Cell-Mediated Protective Roles of B and T Lymphocyte

Although B and T lymphocyte attenuator (BTLA) was originally identiﬁed as an inhibitory coreceptor selectively expressed on Th1 cells and B cells, recent studies have revealed that BTLA is expressed on avarietyof cells, including macrophages, dendritic cells, and NK cells, and modulates their functions. However, the role of BTLA in the regulation of NKT cell function remains unknown. In this study, we found that BTLAwas expressed on NKT cells at the levels similar to those on T cells and that BTLA-deﬁcient (BTLA 2 / 2 ) NKT cells produced larger amounts of IL-4 and IFN- g upon a -glactosylceramide stimulation as compared with wild-type (WT) NKT cells. In vivo, BTLA 2 / 2 mice produced larger amounts of IL-4 and IFN- g upon Con A injection and were more susceptible to Con A-induced hepatitis than WT mice. In addition, the augmentation of Con A-induced hepatitis in BTLA 2 / 2 mice was not observed in BTLA/NKT-double deﬁcient mice. Moreover, NKT 2 / 2 mice reconstituted with BTLA 2 / 2 NKT cells were signiﬁcantly more susceptible to Con A-induced hepatitis as compared with NKT 2 / 2 mice reconstituted with WT NKT cells. These results suggest that BTLA functions as the inhibitory coreceptor of NKT cells and plays a critical role in the prevention of NKT cell-mediated liver injury. The Journal of Immunology , 2010, 184: 000–000.
Fretting study of an impregnated graphite bearing/nitrided stainless steel in a dry contact submitted to severe thermal-vibratory loading

Some industrial applications require the use of self-lubricating materials when fluid lubrication cannot be used. Carbon-based materials and in particular graphites are usually a used solution. However, the application of these materials is limited at high temperature; these materials are exposed to significant degradation and to high friction due to their high sensitivity to the air humidity and to the desorption phenomenon. This study determines the influence of a specific metallic impregnation on the graphite bearing, which is submitted to a severe thermo-vibratory loading by fretting against a stainless steel surface. The stainless steel surface has undergone a nitriding treatment by plasma. During the fretting contact, a strong transfer of the impregnant takes place from the impregnated graphite bearing to the steel conterface by adhesion; this deposit film allows a significant improvement in the tribological properties of the contact surfaces at high temperature.
Effect of friction stir welding tool hardness on wear behaviour in friction stir welding of AA-6060 T66

Friction stir welding is a solid-state joining process with a wide range of industrial applications in the e-mobility, automotive, aerospace and energy industries. However, friction stir welding is subjected to process-specific challenges, including comparatively high process forces and friction stir welding tool wear resulting from tribological interaction between the tool and workpiece. The geometric-related friction stir welding tool wear can cause varying material flow conditions, lateral path deviations and premature tool failure, with detrimental economic and technological consequences. This study systematically analyses the wear behaviour of friction stir welding tools as a function of tool hardness. To compare and differentiate the geometric-related tool wear as a function of tool hardness, experiments were carried out with a hardness of 240 HV, 410 HV and 580 HV. Whereas 240 HV is non-hardened, 410 HV is 50% of the secondary hardness maximum and 580 HV is the secondary hardness maximum of the tools made of H13 tool steel (hot-working steel, X40CrMoV5-1). During the experimental tests, the shoulder and probe exhibited varying wear and geometrical deviations. The investigations were carried out with a force-controlled robotized welding setup in which AA-6060 T66 sheets with a thickness of 8 mm were joined by weld seams up to a total length of 80 m.