Miracle-dz/UniFAR-FTUs huggingface dataset:
A weighting approach to making inference with probabilistically linked data

Record linkage is the act of bringing together records from two files that are believed to belong to the same unit (e.g., a person or business). It is a low‐cost way of increasing the set of variables available for analysis. Errors may arise in the linking process if an error‐free unit identifier is not available. Two types of linking errors include an incorrect link (records belonging to two different units are linked) and a missed record (an unlinked record for which a correct link exists). Naively ignoring linkage errors may mean that analysis of the linked file is biased. This paper outlines a “weighting approach” to making correct inference about regression coefficients and population totals in the presence of such linkage errors. This approach is designed for analysts who do not have the expertise or time to use specialist software required by other approaches but who are comfortable using weights in inference. The performance of the estimator is demonstrated in a simulation study.
Common Marmoset Cell Lines and Their Applications in Biomedical Research

Common marmosets (Callithrix jacchus; CMs) are small New World primates widely used in biomedical research. Early stages of such research often include in vitro experiments which require standardized and well-characterized CM cell cultures derived from different tissues. Despite the long history of laboratory work with CMs and high translational potential of such studies, the number of available standardized, well-defined, stable, and validated CM cell lines is still small. While primary cells and immortalized cell lines are mostly used for the studies of infectious diseases, biochemical research, and targeted gene therapy, the main current applications of CM embryonic stem cells and induced pluripotent stem cells are regenerative medicine, stem cell research, generation of transgenic CMs, transplantology, cell therapy, reproductive physiology, oncology, and neurodegenerative diseases. In this review we summarize the data on the main advantages, drawbacks and research applications of CM cell lines published to date including primary cells, immortalized cell lines, lymphoblastoid cell lines, embryonic stem cells, and induced pluripotent stem cells.
GV1001 Inhibits the Severity of the Ligature-Induced Periodontitis and the Vascular Lipid Deposition Associated with the Periodontitis in Mice

GV1001, a 16 amino acid peptide derived from the catalytic segment of human telomerase reverse transcriptase, was developed as an anti-cancer vaccine. Subsequently, it was found to exhibit anti-inflammatory and anti-Alzheimer’s disease properties. Periodontitis is a risk factor for a variety of systemic diseases, including atherosclerosis, a process in which chronic systemic and vascular inflammation results in the formation of plaques containing lipids, macrophages, foam cells, and tissue debris on the vascular intima. Thus, we investigated the effect of GV1001 on the severity of ligature-induced periodontitis, vascular inflammation, and arterial lipid deposition in mice. GV1001 notably reduced the severity of ligature-induced periodontitis by inhibiting gingival and systemic inflammation, alveolar bone loss, and vascular inflammation in wild-type mice. It also significantly lowered the amount of lipid deposition in the arterial wall in ApoE-deficient mice receiving ligature placement without changing the serum lipid profile. In vitro, we found that GV1001 inhibited the Receptor Activator of NF-κB ligand (RANKL)-induced osteoclast formation and tumor necrosis factor-α (TNF-α)-induced phenotypic changes in endothelial cells. In conclusion, our study suggests that GV1001 prevents the exacerbation of periodontitis and atherosclerosis associated with periodontitis partly by inhibiting local, systemic, and vascular inflammation and phenotypic changes of vascular endothelial cells.
A Case of Invasive Fungal Infection Due to Scedosporium apiospermum in a Patient with Psoriasis

Abstract Scedosporium apiospermum (S. apiospermum) is typically reported to be involved in superficial and subcutaneous fungal infections but overlooked in invasive infections, which is associated with a high mortality rate. It poses a diagnostic challenge due to its confusable characteristics to other hyaline hyphomycetes. Here, we reported a psoriasis patient with an invasive S. apiospermum infection. The patient presents an abscess at the intermuscular space of the left hip and an increased C-reactive protein level. Pus culture showed white-greyish, cottonlike colonies with aerial mycelium and terminal oval conidia, suggesting S. apiospermum. This rare fungus was rapidly confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and RNA sequencing. The patient was successfully treated with voriconazole with no recurrence of the abscesses despite delayed treatment. This is the first such case infection report from China that described an unusual case of intermuscular space abscesses due to S. apiospermum. This report highlights the possibility of fungal infections in deeper tissue, as well as the necessity of thorough evaluation and microbiological diagnosis for invasive infections, particularly in immunocompromised patients.
The Relationships Between Smoking Intention and Various Dimensions of Health Literacy Among University Students

Background: Cigarette Smoking plays an important role in causing chronic diseases around the world and its consumption among adolescents is quickly increasing. Significant relationship has been reported between the smoking status and health literacy. Objective: This investigation aimed at recognizing the relationships between smoking intention and various dimensions of health literacy in university students. Methods: In the current cross-sectional investigation, 542 students of Mashhad Universities of Applied Sciences were collected using cluster sampling method. Data collection tools were sociodemographic, health literacy, and smoking intention questionnaire. Data were analyzed through SPSS software. Results: Among the various investigated dimensions of health literacy, the decision making and health information application dimension has the lowest score and the reading skills and access dimensions have the highest score, respectively. Results showed that the smoking intention was associated significantly with decision making (ß Standard: -0.27, Confidence interval: -0.03 - -0.01) and health information application and access dimensions (ß Standard: -0.3, Confidence interval: -0.03 - -0.02). Furthermore, decision making and health information application dimension was the strongest smoking intention predictor. Conclusion: Recognizing the skills that are most strongly associated with smoking decision-making can help designers develop clear, informative, and actionable programs and training. The findings of this investigation indicated the fact that in order to reduce the intention of smoking and in contrast to increase carrying out preventive and healthy behaviors among university students, specific consideration must be had to the factor of health literacy and its effective dimensions.
Cardiovascular safety of Janus kinase inhibitors in patients with rheumatoid arthritis: systematic review and network meta-analysis

Background: Janus kinase (JAK) inhibitors have emerged as a progressively utilized therapeutic approach for the management of rheumatoid arthritis (RA). However, the complete determination of their cardiovascular safety remains inconclusive. Hence, the primary objective of this network meta-analysis is to meticulously assess and juxtapose the cardiovascular risks linked to distinct JAK inhibitors employed in RA patients. Methods: A systematic review and network meta-analysis were meticulously conducted, encompassing a collection of randomized controlled trials (RCTs) that focused on investigating the incidence of major adverse cardiovascular events (MACE) and all-cause mortality associated with Janus kinase (JAK) inhibitors administered to patients with rheumatoid arthritis (RA). Extensive exploration was performed across multiple electronic databases, incorporating studies published until March 2023. To be included in this analysis, the RCTs were required to involve adult participants diagnosed with RA who received treatment with JAK inhibitors. To ensure accuracy, two authors independently undertook the selection of eligible RCTs and meticulously extracted aggregate data. In order to examine the outcomes of MACE and all-cause mortality, a frequentist graph theoretical approach within network meta-analyses was employed, utilizing random-effects models. Third study has been registered on PROSPERO under the reference CRD42022384611. Findings: A specific selection encompassing a total of 14 meticulously chosen randomized controlled trials was undertaken, wherein 13,524 patients were assigned randomly to distinct treatment interventions. The analysis revealed no notable disparity in the occurrence of major adverse cardiovascular events (MACE) between the interventions and the placebo group. However, in comparison to adalimumab, the employment of JAK inhibitors exhibited an association with higher rates of all-cause mortality [odds ratio (OR): 1.7, 95% confidence interval (CI): 1.02–2.81]. This observed increase in risk primarily stemmed from the usage of tofacitinib (OR: 1.9, 95% CI: 1.12–3.23). None of the other JAK inhibitors exhibited a statistically significant variance in all-cause mortality when compared to adalimumab. Interpretation: Our study suggests that JAK inhibitors may not increase the risk of MACE in RA patients but may be associated with a higher risk of all-cause mortality compared to adalimumab, primarily due to tofacitinib use. Rheumatologists should carefully consider the cardiovascular risks when prescribing JAK inhibitors, particularly tofacitinib, for RA patients. Systematic Review Registration: https://www.crd. york.ac. uk/PROSPERO/display_record. php? RecordID=384611, CRD42022384611.
Pro-environmental behavior of learners using CADMIACA model

This research provides clear perspective with broad spectrum on the pro-environmental behavior (PEB) of learners. It sought to determine the level of awareness, attitudes, intention, motivation, environmental social interaction, environmental education and green behavior of learners, and the significant relationship and significant difference among the variables. The researcher utilized the descriptive-qualitative survey method; through the use of a questionnaire backed up with Key Informant Interview (KII) and triangulated by Focus Group Discussion (FGD). CADMIACA, the model of this research, are from the theories of Comprehensive Action Determination Model (CADM) Motivational, Interpersonal ones (MI) and the Action Competence Approach (ACA). For the empirically causal relationship among variables, structural equation methodology (SEM) was initiated. The study included 384 learners from junior and senior high school of NDDU-IBED Lagao, General Santos City, school year 2017-2018. Overall, there is no significant difference on the PEB of junior and senior high school learners; they had a moderate energy-saving behavior and high level of environmental education. On the other hand, there is a significant difference in the attitude and global warming of students. Another study is recommended, using other respondents from a subdivision or barangay to determine whether social status might affect the totality of PEB of an individual.
Effect of heat-flux boundary conditions on the Rayleigh-Bénard instability in a rarefied gas

We consider the effect of heat-ﬂux boundary conditions, replacing the previously studied isothermal wall conditions, on the Rayleigh-Bénard instability in a rareﬁed gas. The problem is investigated in the limit of small Knudsen numbers, by means of a linear stability analysis of a slip ﬂow model, and the direct simulation Monte Carlo method. In the latter, a noniterative algorithm is applied to implement the heat-ﬂux conditions. The results delineate the instability domain in the parameters plane of the Knudsen number (Kn), Froude number (Fr), and walls reference temperature ratio. The heat-ﬂux conditions result in a signiﬁcant destabilizing effect, extending instability to larger Knudsen numbers. At large Fr, the Boussinesq limit is recovered, and transition to instability is governed by a critical value of the Rayleigh number. With decreasing Fr, gas compressibility becomes dominant, conﬁning the convection layer to the vicinity of the upper cold wall. Asymptotic analysis of the low-Fr limit is carried out, to highlight the impact of difference in thermal conditions. The Monte Carlo scheme is applied to investigate system instability at supercritical states, where walls heat-ﬂux conditions lead to elevated shear stresses. Nonmonotonic variations in the walls shear stress with Kn are observed and discussed.
Enrichment of Anammox Bacteria Using Anammox Sludge as a Primer Combined with Ordinary Activated Sludge

Anaerobic ammonia oxidation bacteria (AnAOB) are difficult to cultivate due to their long start-up time and sensitivity to environmental conditions. In this study, anammox granular sludge was cultured with ordinary activated sludge under influent dissolved oxygen concentrations of 6–8 mg/L, successfully enriching AnAOB. The presence of multiple microorganisms in the activated sludge enabled the anammox system to resist the unfavorable influent environment and sustain system stability. The total nitrogen removal rate reached a maximum of 81%, and the TN effective load increased from 0.1 to 1.5 kg N/m3/d. The results showed that the dissolved oxygen present in the influent did not lead to a breakdown in the anammox system. The protein in the sludge extracellular polymeric substances played an important role in the enrichment of AnAOB, and the sludge settling performance at the bottom of the reactor was better than that at the top of the reactor, with protein/polysaccharide in the range of 5–6.3. Candidatus brocadia and Candidatus kuenenia were the main anammox functional bacteria in the system. On 153 d of reactor operation, their relative abundances were 8.51 and 5.68%, respectively. This study shows that microorganisms in activated sludge contribute to the stability of the anammox system when the influent conditions are appropriate. This provides a new idea for the rapid start-up of the anammox system and enrichment of AnAOB.
Conditions : A Metanarrative Review

McKillop, A. , Shaw, J., Sheridan, N. , Gray, C. S. , Carswell, P., Wodchis, W. P., . Kenealy, T. (2017). Understanding the Attributes of Implementation Frameworks to Guide the Implementation of a Model of Community-based Integrated Health Care for Older Adults with Complex Chronic Conditions: A Metanarrative Review. International Journal of Integrated Care, 17(2), 14 pages. doi:10.5334/ijic.2516
Search for Dark Matter in Events with Missing Transverse Momentum and a Higgs Boson Decaying to Two Photons in pp Collisions at √s = 8 TeV with the ATLAS Detector

Aad, G. ; et al., [Unknown]; Aben, R. ; Angelozzi, I. ; Beemster, L.J.; Bentvelsen, S. ; Berge, D. ; Bobbink, G.J.; Bos, K. ; Brenner, L. ; Butti, P.; Castelli, A. ; Colijn, A.P.; de Jong, P.; de Nooij, L. ; Deigaard, I. ; Deluca, C. ; Ferrari, P.; Gadatsch, S. ; Geerts, D.A. A. ; Hartjes, F. ; Hessey, N.P.; Hod, N. ; Igonkina, O. ; Karastathis, N. ; Kluit, P.; Koffeman, E. ; Linde, F. ; Mahlstedt, J.; Meyer, J.; Oussoren, K.P.; Sabato, G. ; Salek, D. ; Slawinska, M. ; Valencic, N. ; van den Wollenberg, W. ; van der Deijl, P.C. ; van der Geer, R. ; van der Graaf, H. ; van der Leeuw, R. ; van Vulpen, I. ; Verkerke, W. ; Vermeulen, J.C. ; Vreeswijk, M. ; Weits, H. ; Williams, S. DOI 10.1103/PhysRevLett.115. 131801 Publication date 2015 Document Version Final published version Published in Physical Review Letters
Job Satisfaction Among Healthcare Workers Working During COVID-19 Pandemic at a Private Teaching Hospital in Nepal.

Background: COVID-19 pandemic has created many serious challenges to the frontline workers in their day-to-day job activities. Job satisfaction among healthcare workers is most predominant component to smooth functioning of institutional activities and to improve the quality of patient care. Objective: To find out job satisfaction among frontline healthcare workers during COVID-19 pandemic. Methods: A cross-sectional study was conducted among 228 healthcare workers (doctors and nurses) working in Chitwan Medical College Teaching Hospital (CMC-TH) during the COVID-19 pandemic. A simple random sampling technique was used to select the sample and a self-administered structured questionnaire with a job satisfaction scale was used to collect the data. Obtained data were analyzed in SPSS version 20 for Windows using descriptive and inferential statistics. Results: The majority (71.1%) of the healthcare workers were ambivalent whereas few (18%) were satisfied, and 11.0% were dissatisfied with their job during the COVID-19 pandemic. Healthcare workers' median percentage satisfaction score was higher on the domains of coworkers (70.8%), nature of work (70.8%), and supervision (70.8%) whereas lower on fringe benefits (54.2%), and contingent rewards (54.2%) other domains. There was a statistically significant association between job satisfaction level with age (p=0.037), marital status (p= <0.001) and experience (p=0.016) of the doctors and nurses. Conclusions: Job satisfaction is very low among healthcare workers in a teaching hospital. Hence, appropriate strategies are needed to be implemented considering the identified domains of satisfaction to enhance the healthcare workers’ job satisfaction and quality patients’ care.
Innate Immune Dysfunction in Trauma Patients: From Pathophysiology to Treatment

S EVERE trauma is a leading cause of death in young healthy individuals. Despite significant advances in the fields of resuscitation and modern intensive care medicine, infection remains the most frequent cause of poor outcome in severely injured patients. Osborn et al. have demonstrated that sepsis, and particularly ventilator-associated pneumonia, were associated with a significant increase in mortality after severe trauma. 1 In the same study, septic trauma patients also presented an increased intensive care unit length of stay as compared with patients without infection (21.8 vs . 4.7 days, P (cid:1) 0.001). A marked depression of cell-mediated immune function, so-called “posttraumatic immunosupres-sion,” occurs after trauma and appears to contribute to poor clinical outcome.
The Role of Potentially Preventable Hospital Exposures in the Development of Acute Respiratory Distress Syndrome: A Population-Based Study*

Objective:Acute respiratory distress syndrome is a common complication of critical illness, with high mortality and limited treatment options. Preliminary studies suggest that potentially preventable hospital exposures contribute to acute respiratory distress syndrome development. We aimed to determine the association between specific hospital exposures and the rate of acute respiratory distress syndrome development among at-risk patients. Design:Population-based, nested, Matched case-control study. Patients:Consecutive adults who developed acute respiratory distress syndrome from January 2001 through December 2010 during their hospital stay (cases) were matched to similar-risk patients without acute respiratory distress syndrome (controls). They were matched for 6 baseline characteristics. Interventions:None. Measurements and Main Results:Trained investigators blinded to outcome of interest reviewed medical records for evidence of specific exposures, including medical and surgical adverse events, inadequate empirical antimicrobial treatment, hospital-acquired aspiration, injurious mechanical ventilation, transfusion, and fluid and medication administration. Conditional logistic regression was used to calculate the risk associated with individual exposures. During the 10-year period, 414 patients with hospital-acquired acute respiratory distress syndrome were identified and matched to 414 at-risk, acute respiratory distress syndrome-free controls. Adverse events were highly associated with acute respiratory distress syndrome development (odds ratio, 6.2; 95% CI, 4.0–9.7), as were inadequate antimicrobial therapy, mechanical ventilation with injurious tidal volumes, hospital-acquired aspiration, and volume of blood products transfused and fluids administered. Exposure to antiplatelet agents during the at-risk period was associated with a decreased risk of acute respiratory distress syndrome. Rate of adverse hospital exposures and prevalence of acute respiratory distress syndrome decreased during the study period. Conclusions:Prevention of adverse hospital exposures in at-risk patients may limit the development of acute respiratory distress syndrome.
The effectiveness of peroneal nerve stimulation combined with neuromuscular electrical stimulation in the management of knee osteoarthritis: A randomized controlled single-blind study

Objectives This study aimed to compare the effectiveness of neuromuscular electrical stimulation (NMES) combined with peroneal nerve stimulation (PNS) on muscle strength around the knee, proprioception, pain, functional status, and quality of life in patients with knee osteoarthritis (OA). Patients and methods The prospective, randomized, single-blinded, controlled trial included 63 patients with clinical and radiological diagnoses of knee OA between December 2019 and March 2020. The patients were divided into two groups: Group 1 (NMES+PNS, n=31) and Group 2 (NMES, n=32). The patients were followed up at two and six weeks. Main outcome measures were the Visual Analog Scale, Western Ontario and McMaster Universities Arthritis Index, Nottingham Health Profile, and 100-m walking test, quadriceps muscle strength, hamstring muscle strength (HMS), and joint position sense were evaluated using a computer-controlled isokinetic dynamometer at 60°/sec, 90°/sec, and 120°/sec angular velocities. The proprioception was evaluated at 30° and 60° flexion angles using the same device. Results Two patients from Group 1 and two patients from Group 2 were excluded from the study after they failed to show up for the six-week control. As a result, the study was completed with 59 patients (30 females, 29 males; 55.9±6.1 years; range, 40 to 65 years). There was a significant difference between the two groups in the 100-m walking test parameter at the six-week control in favor of Group 1 (p<0.05). There was a significant difference in favor of Group 1 in the parameters of proprioception (30° and 60°) and HMS (60° and 90°) in both the two-week evaluation and six-week controls (p<0.05). The HMS 120° parameter showed a significant difference in favor of Group 1 at the six-week control (p<0.05). Conclusion In patients with knee OA, we believe that PNS combined with NMES may be more effective than NMES treatment alone in terms of proprioception, HMS, and functional status.