Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic Equivalence Evaluated Through In Vitro Studies of Multi-Source Drugs: A Moxifloxacin Case Study in Lima, Peru

This study aimed to determine the therapeutic equivalence of four multi-source drugs containing moxifloxacin (400 mg tablets) in vitro studies to establish their interchangeability with the reference product. Four multi-source products were acquired in pharmaceutical establishments in metropolitan Lima, each from different manufacturing sites (two products from India, one from Brazil, and one from Peru). The reference product was Avelox (400 mg) coated tablets (Bayer AG, Germany). Quality control and dissolution profile tests were performed. For dissolution tests, a validated ultraviolet-visible spectrophotometry method was used to determine the percentage of drug released. The similarity factor (f2) analysis was used to establish therapeutic equivalence of the drug release curves. The dissolution rates were considered equivalent if the values of f2 were between 50 and 100. Concerning the quality control tests, the moxifloxacin content was 98.5% in the reference product and 97.1–100.0% in the multisource products. Three out of four multi-source products passed the f2 test at pH 1.2. Therefore, there is at least one moxifloxacin multi-source product circulating in Peru, manufactured in India, that does not is not interchangeable with the reference product.
A Cadaveric Study on the Anomalous Extensors of the Hand

Background: The hands play a pivotal role in skilled movements. Anomalous muscles of the extensors of the hand are seen usually in anatomical dissections and during surgeries. Variations of the muscles in the dorsum of hand may be asymptomatic or may cause dorsal wrist pain, particularly if a muscle belly encroaches on and obstruct the wrist's small extensor compartments deep to extensor retinaculum. Methods: A total of 54 upper limb specimens were used for the current study from the Anatomy Department of an undergraduate & postgraduate teaching Medical College in India. Incidence of additional muscle belly and its tendon in the posterior compartment of the forearm and dorsum of the hand were noted and photographed. Results: The anomalous muscle bellies and tendons in extensor compartment of forearm and dorsum of hand were observed in 10 limbs (18.5%) of 54 limbs. Of which, the extensor medii proprius (EMP) was 9.3%, extensor digitorum brevis manus (EDBM) was 3.7%. The numbers of the tendon of the extensor digitorum (ED) were varied in 3 limbs (5.6%). Conclusion: Knowledge of anatomical data of such variant muscles and additional belly or tendon in the extensor compartment of forearm and dorsum of hand is essential for surgeons to modify treatment plan, so as to avoid reporting error and of surgical procedures while operating on hand. KEY WORDS: Hand extensors, Anomalous muscles, Extensor mediiproprius, Extensor digitorum brevis manus, Extensor digitorum.
Increasing Mortality in Venovenous Extracorporeal Membrane Oxygenation for COVID-19–Associated Acute Respiratory Distress Syndrome

OBJECTIVES: Determine the factors associated with mortality in venovenous extracorporeal membrane oxygenation (V-V ECMO) patients with COVID-19 infection and provide an updated report of clinical outcomes for patients treated with V-V ECMO for COVID-19 in Minnesota. DESIGN: Multicenter prospective observational study. SETTING: The four adult Extracorporeal Life Support Organization–certified Centers of Excellence in Minnesota. PATIENTS: A total of 100 patients treated with V-V ECMO for COVID-19–associated acute respiratory distress syndrome (ARDS) from March 2020 to May 2021. INTERVENTIONS: Not applicable. MEASUREMENTS AND MAIN RESULTS: The primary outcome was 60-day survival for patients treated with V-V ECMO for COVID-19. Outcomes of patients treated from November 2020 to May 2021(cohort 2) were compared with data from a previous cohort of patients, collected from March 2020 to October 2020 (cohort 1). The data from both cohorts were merged into a single dataset (Combined Cohort). Survival on V-V ECMO due to COVID-19–associated ARDS significantly decreased after October 2020 (63% vs 41%; p = 0.026). The median interval from hospital admission to V-V ECMO cannulation was significantly associated with 60-day mortality (10 d [6–14 d] in nonsurvivors vs 7 d [4–9 d] in survivors; p = 0.001) in the Combined Cohort and was also significantly longer in cohort 2 than cohort 1 (10 d [7–14 d] vs 6 d [4–10 d]; p < 0.001). In the Combined Cohort, the 60-day survival for patients who did not receive steroids was 86% (n = 12) versus 45% (n = 39) for patients who received at least one dose of steroids (p = 0.005). CONCLUSIONS: There was a significant increase in mortality for patients treated with V-V ECMO for COVID-19–associated ARDS in cohort 2 compared with cohort 1. Further research is required to determine the cause of the worsening trend in mortality.
The Effect of Competency-Based Curricula on the Promotion of Social Values and Civic Education in the Pre-University Education: Case of Kosovo

This study investigates teachers’ understanding of the competency-based curriculum framework. In addition, it investigates teachers’ opinions on the promotion of civic education and social values through the curricular framework, and what impediments teachers face in implementing the curriculum on the civic education subject. A questionnaire, including structured and open-ended questions, was developed and distributed to 318 teachers. Findings of this study indicated that the majority of teachers understand the curricular framework including core and subject curricula, related to civic education and social values. In addition, findings indicate there are inadequate textbooks and insufficient professional development and training of teachers. Findings also indicate that inappropriate infrastructure and adequate equipment have a negative effect on the implementation of competency-based curricula. Recommendations highlight the need for a revision of textbooks based on the curricular framework provisions and additional training of teachers on implementing the competency-based curriculum. In addition, there is a need for providing adequate working conditions for teachers. Recommendation for future research is to include other factors such as students’ performance and outcomes of the educational process. Received: 15 November 2021 / Accepted: 20 January 2022 / Published: 5 March 2022
The effects of sponsorship disclosures, advertising knowledge, and message involvement in sponsored influencer posts

Abstract Influencers are required to make disclosures while posting sponsored content on social media. This study examined what kind of disclosures are effective and how prominent disclosures interact with advertising knowledge and message involvement to affect the recognition of sponsored influencer posts on Instagram. It conducted an online experiment (N = 296) with a 2 (disclosure type: prominent vs. subtle) × 2 (advertising knowledge: enhanced vs. not enhanced) x 2 (message involvement: high vs. low) between-subjects factorial design. Results revealed that people with enhanced advertising knowledge or with high message involvement led to greater advertising recognition, regardless of the degree of disclosure prominence. While on the other hand, when people’s knowledge of sponsored influencer content was not enhanced or when they were low in message involvement, the prominent disclosure was more effective than the subtle one in improving advertising recognition. Furthermore, recognizing sponsored content elicited resistance, which in turn led to less favourable attitude towards the brand. The theoretical and practical implications of these findings were discussed.
Tunable band gap in twisted bilayer graphene

At large commensurate angles, twisted bilayer graphene which holds even parity under sublattice exchange exhibits a tiny gap. Here, we point out a way to tune this tiny gap into a large gap. We start from comprehensive understanding of the physical origin of gap opening by density functional theory calculations. We reveal that the effective inter-layer hopping, intra-layer CDW, or inter-layer charge imbalance favors a gap. Then, on the basis of tight-binding calculations, we suggest that a periodic transverse inhomogeneous pressure, which can tune inter-layer hoppings in specific regions of the moi$\rm\acute{r}$e supercell, may open a gap of over $100$~meV, which is further confirmed by first-principles calculations. Our results provide a theoretical guidance for experiments to open a large gap in twisted bilayer graphene.
Ad-Corre: Adaptive Correlation-Based Loss for Facial Expression Recognition in the Wild

Automated Facial Expression Recognition (FER) in the wild using deep neural networks is still challenging due to intra-class variations and inter-class similarities in facial images. Deep Metric Learning (DML) is among the widely used methods to deal with these issues by improving the discriminative power of the learned embedded features. This paper proposes an Adaptive Correlation (Ad-Corre) Loss to guide the network towards generating embedded feature vectors with high correlation for within-class samples and less correlation for between-class samples. Ad-Corre consists of 3 components called Feature Discriminator, Mean Discriminator, and Embedding Discriminator. We design the Feature Discriminator component to guide the network to create the embedded feature vectors to be highly correlated if they belong to a similar class, and less correlated if they belong to different classes. In addition, the Mean Discriminator component leads the network to make the mean embedded feature vectors of different classes to be less similar to each other.We use Xception network as the backbone of our model, and contrary to previous work, we propose an embedding feature space that contains k feature vectors. Then, the Embedding Discriminator component penalizes the network to generate the embedded feature vectors, which are dissimilar.We trained our model using the combination of our proposed loss functions called Ad-Corre Loss jointly with the cross-entropy loss. We achieved a very promising recognition accuracy on AffectNet, RAF-DB, and FER-2013. Our extensive experiments and ablation study indicate the power of our method to cope well with challenging FER tasks in the wild.
Growth, yield components and grain yield response of rice to temperature and nitrogen levels

An experiment was carried out during the kharif season of year 2013 inside Temperature Gradient Tunnel (TGT) of Centre for Environment Science and Climate Resilient Agriculture (CESCRA), at IARI farm to study impact of elevated temperature on the growth and yield responses of rice crop under four N levels. Results showed that grain and biomass yield of rice had decreased significantly with rise in temperature inside the TGT. With recommended N dose, yield reduction of rice was 37 per cent with rise in temperature to 3. 9ºC over ambient air condition but application of 125 per cent N can prevent the yield loss by 6per cent as compared to 100 per cent recommended N treatment. Yield parameters Spikelet sterility of rice did increase with increase in temperature.
Liver Transplantation for Pediatric Hepatocellular Carcinoma: A Systematic Review

Simple Summary Hepatocellular carcinoma is a type of primary liver cancer and the second most common type of liver cancer in children. Although partial hepatectomy can be curative, many children present with tumors that are not amenable to resection and thus the only potentially curative option is liver transplantation. In this systematic review, we have pooled the data from the worldwide literature and showed that survival after liver transplantation for pediatric hepatocellular carcinoma is favorable and many children do well even if their tumors exceed certain potentially restrictive criteria originally developed to select adults with hepatocellular carcinoma for liver transplantation. Abstract Liver transplantation (LT) is the only potentially curative option for children with unresectable hepatocellular carcinoma (HCC). We performed a systematic review of the MEDLINE, Scopus, Cochrane Library, and Web of Science databases (end-of-search date: 31 July 2020). Our outcomes were overall survival (OS) and disease-free survival (DFS). We evaluated the effect of clinically relevant variables on outcomes using the Kaplan–Meier method and log-rank test. Sixty-seven studies reporting on 245 children undergoing LT for HCC were included. DFS data were available for 150 patients and the 1-, 3-, and 5-year DFS rates were 92.3%, 89.1%, and 84.5%, respectively. Sixty of the two hundred and thirty-eight patients (25.2%) died over a mean follow up of 46.8 ± 47.4 months. OS data were available for 222 patients and the 1-, 3-, and 5-year OS rates were 87.9%, 78.8%, and 74.3%, respectively. Although no difference was observed between children transplanted within vs. beyond Milan criteria (p = 0.15), superior OS was observed in children transplanted within vs. beyond UCSF criteria (p = 0.02). LT can yield favorable outcomes for pediatric HCC beyond Milan but not beyond UCSF criteria. Further research is required to determine appropriate LT selection criteria for pediatric HCC.
Immunogenicity of SARS-CoV-2 BNT162b2 Vaccine in People with Diabetes: A Prospective Observational Study

The mRNA-based BNT162b2 vaccine has demonstrated high efficacy against severe SARS-CoV-2. However, data regarding immune response in people with diabetes mellitus (DM) after vaccination with the BNT162b2 vaccine are limited. In this prospective observational study, we examined humoral immune response in participants with and without DM after vaccination with the BNT162b2 mRNA vaccine. A total of 174 participants (58 with and 116 without diabetes, matched for age) were included. Antibodies were measured 21 days after the first dose, 7–15 days after the second dose, and 70–75 days after the second and before the third dose of the vaccine. Antibodies were measured by an anti-SARS-CoV-2 receptor-binding domain IgG (Abs-RBD-IgG) assay by a chemiluminescent microparticle immune assay; values > 50 AU/mL are considered protective from severe disease. Almost 17% of participants with DM did not develop adequate humoral immune response to the BNT162b2 mRNA vaccine after the first dose; however, it was high and similar after the second dose in both participants with and without DM and remained so almost 2 months after the second dose of the vaccine. Geometric mean values of Abs-RBD-IgG were not significantly different between participants with and without DM during the study. At least two doses of the BNT162b2 vaccine are necessary to ensure adequate and sustainable immune response in people with DM.
Probiotic Foods Are Effective on Weight Loss, Biochemical Parameters, and Intestinal Microbiota in Wistar Albino Rats with Obese Microbiota

The positive effects of various probiotic foods on weight control, intestinal microbiota, and biochemical markers have been proven by various studies. However, there is no study on such effects of tarhana and kefir + tarhana consumption, a type of Turkish food rich in Lactobacillus spp. , Pediococcus pentosaceus, Pediococcus acidilactici, and Saccharomyces cerevisiae. This study aimed to determine the changes caused by regular consumption of kefir and/or tarhana for 6 months on weight gain, intestinal microbiota, and biochemical parameters in Wistar albino rats with obese microbiota. Therefore, thirty-five rats were fed with five different methods of oral gavage (n = 7 per group): Normal Diet Control (NDC), High Fat Diet Control (HFDC), 6 mL/kg Kefir + High Fat Diet (Kefir + HFD), 0.2 g/kg Tarhana + High Fat Diet (Tarhana + HFD), and 6 mL/kg Kefir + 0.2 g/kg Tarhana + High Fat Diet (Kefir + Tarhana + HFD). Normality tests were evaluated using the One-Sample Kolmogorov test and Histogram graph. Multiple group comparisons were performed using one-way ANOVA and Tukey's HSD post hoc test, and the statistical significances were indicated by different letters (p < 0.05). Comparisons by gender were performed using the independent samples t-test. Kefir consumption was more effective on decreasing weight gain. Obese microbiota significantly increased blood glucose level and decreased red blood cell (RBC), hematocrit (HCT), hemoglobin, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelets (PLT), and white blood cells. RBC and HCT values in Kefir + HFD, PLT value in Tarhana + HFD, and mean corpuscular volume (MCV), MCH, and MCHC values in Kefir + Tarhana + HFD were higher than those of other groups (p < 0.05). Kefir + tarhana consumption significantly showed an increase in blood glucose. Kefir and/or tarhana induced the abundance of Lactobacillus and blocked the abundances of total coliform bacteria and Escherichia coli (p < 0.05). We demonstrated that kefir was effective in decreasing weight gain, and all dietary interventions induced positive alterations on biochemical findings and intestinal microbiota.
Nail-Associated Body-Focused Repetitive Behaviors: Habit-Tic Nail Deformity, Onychophagia, and Onychotillomania

Habit-tic nail deformity, onychophagia (also referred to as nail biting) and onychotillomania (also referred to as nail picking) are body-focused repetitive behaviors that can involve the nails and periungual skin. Patients with habit-tic nail deformity are typically unaware that repeatedly using their nail, often the adjacent index finger, to rub the proximal nail fold and its underlying matrix - usually of one or both of their thumbnails - is the cause of the longitudinal depressed groove that extends along the entire the nail plate. Nail biters usually bite multiple nails - most commonly on the digits of the hands - and the patient is cognizant of their behavior. However, the term onychophagia is a misnomer and onychodaxia would be a more appropriate nomenclature. Nail pickers also often realize that their dystrophic nail results from using other nails or tools to pick, pull, or excessively manicure the affected nail. Individuals with habit-tic nail deformity or onychophagia or onychotillomania may concurrently have other repetitive behaviors involving the skin or the hair or both. Three patients with a nail-associated body-focused repetitive behavior are described who not only presented with dystrophy of their nails but also abnormalities of the adjacent nail apparatus: a 36-year-old woman with habit-tic nail deformity and dermatodaxia, a 64-year-old man with biting of both the nails and the skin, and a 63-year-old man with nail picking and skin picking. The nail dystrophy and concurrent skin biting or skin picking were not the issues that prompted the reported patients to seek evaluation by a physician; the body-focused repetitive behaviors of the nails and skin were incidental findings during their cutaneous examination. The management of nail-associated body-focused repetitive behavior may include non-pharmacologic treatments (such as physical modalities and behavior modifications) and/or pharmacologic agents. The reported woman with habit-tic nail deformity was willing to consider an attempt to modify her repetitive behavior by using paper tape as a physical modality to cover the area on her thumbs that she would unconsciously rub. However, similar to the men in this report with onychophagia and onychotillomania, many of the patients with nail-focused repetitive behaviors do not want to initiate any interventions that might decrease or eliminate their nail condition.
The Role of Social Media in Implementing the Concept of “Soft Power”

The study examines the role of social networks in social and political processes. Today, social networks are an effective tool for the implementation of “soft power”, having a significant impact on the political agenda, international relations and social processes within states. In fact, social networks create new formats of interaction between social groups and institutions, as a rule, unlimited by the territories of individual states. The results of such interaction can be both constructive and destructive in terms of their impact on the existing strategy of social development. With an increase in the proportion of the country's population actively participating in social networks, the risks of social and political threats associated with the massive use of these communication technologies increase. The article examines the main global factors that determine the pace and direction of development of social networks, as well as the features of their operation in Russia. The authors analyze changes in the structure of users of the largest Russian-speaking social networks in 2014-2018, that is, during the period of their stabilization after rapid development in 2011-2013. The article also raises the problem of targeted informational impact on users of social networks and the formation of personal information capsules for them, allowing them to form a significant manipulative potential in the field of socio-political communications. According to the results of the study, it was concluded that the processes of development of Russian-speaking social networks continue, they are gradually being politicized, accompanied by the formation of a manipulative potential. Consequently, the role of social networks in the implementation of "soft power" is growing, but the nature and vector of action of this force will depend on which specific social groups or institutions will have an effective informational impact on users of social networks.
The effect of BC on aerosol–boundary layer feedback: potential implications for urban pollution episodes

Abstract. Beijing suffers from poor air quality, particularly during wintertime haze episodes when concentrations of PM2.5 (particulate matter with a diameter < 2.5 µm) can peak at > 400 µg m−3. Black carbon (BC), an aerosol which strongly absorbs solar radiation, can make up to 10 % of PM2.5 in Beijing. BC is of interest due to its climatic and health impacts. BC has also been found to impact planetary boundary layer (PBL) meteorology. Through interacting with radiation and altering the thermal profile of the lower atmosphere, BC can either suppress or enhance PBL development depending on the properties and altitude of the BC layer. Previous research assessing the impact of BC on PBL meteorology has been investigated through the use of regional models, which are limited both by resolution and the chosen boundary layer schemes. In this work, we apply a high-resolution model (UCLALES-SALSA) that couples an aerosol and radiative transfer model with large-eddy simulation (LES) to quantify the impact of BC at different altitudes on PBL dynamics using conditions from a specific haze episode which occurred from 1–4 December 2016 in Beijing. Results presented in this paper quantify the heating rate of BC at various altitudes to be between 0.01 and 0.016 K/h per µg/m3 of BC, increasing with altitude but decreasing around PBL top. Through utilising a high-resolution model which explicitly calculates turbulent dynamics, this paper showcases the impact of BC on PBL dynamics both within and above the PBL. These results show that BC within the PBL increases maximum PBL height by 0.4 % but that the same loading of BC above the PBL can suppress PBL height by 6.5 %. Furthermore, when BC is present throughout the column, the impact of BC suppressing PBL development is further maximised, with BC causing a 17 % decrease in maximum PBL height compared to only scattering aerosols. Assessing the impact of these opposite effects, in this paper, we present a mechanism through which BC may play a prominent role in the intensity and longevity of Beijing's pollution episodes.