Miracle-dz/UniFAR-FTUs huggingface dataset:
Pediatric cardiac surgery following severe acute respiratory syndrome coronavirus-2 infection: Early experience and lessons learnt

Background : We evaluated our early experience of cardiac procedures in children with congenital heart defects (CHD) after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to understand whether recent reverse transcription-polymerase chain reaction (RT-PCR) positivity had a negative impact on their postprocedural recovery and outcomes. Materials and Methods : In this retrospective observational study, all patients with CHD who underwent cardiac surgery or transcatheter intervention at our institution between March 2020 and June 2021 who were detected to have asymptomatic SARS-CoV-2 infection on routine RT-PCR were included. Details of the cardiac procedure and postprocedural recovery were reviewed and compared with RT-PCR-negative patients who concurrently underwent similar cardiac surgeries or interventions at our center. Results : Thirteen patients underwent cardiac surgery after recent SARS-CoV-2 positivity after a mean interval of 25.4 ± 12.9 days. One patient expired with multiorgan dysfunction and systemic inflammatory response with elevated D-dimer, serum Ferritin, C-reactive protein, and significant ground-glass opacities on chest radiograph. Another patient developed spontaneous thrombosis of the infrarenal abdominal aorta, bilateral iliac arteries, and bilateral femoral veins, requiring low-molecular weight heparin postoperatively. This patient's postoperative recovery was also prolonged due to lung changes delaying extubation. All other patients had uneventful postprocedural recovery with intensive care unit and hospital stays comparable to non-SARS-CoV-2-infected patients. Conclusions : From our early experience, we can surmise that an interval of 2–3 weeks after asymptomatic SARS-CoV-2 infection is adequate to undertake elective or semi-elective pediatric cardiac surgeries. For patients requiring emergent cardiac surgery prior to this interval, there is potentially increased risk of inflammatory and/or thrombotic complications.
Association between pulmonary vein stenosis and necrotizing enterocolitis or gastrointestinal pathology: A case–control study

Objective : Pulmonary vein stenosis (PVS) is an emerging cause of pulmonary hypertension in preterm infants. It is an often lethal condition with poor long.term prognosis and high mortality. Previous work suggests an association between necrotizing enterocolitis (NEC) and PVS, supporting a possible role for inflammatory processes due to gastrointestinal (GI) pathology as an associated risk factor for PVS. Study Description : We performed a matched case–control study where infants with PVS were matched for gestational age with infants without PVS. Hospital records were reviewed for prior history of NEC or other gut pathology. Results : Twenty-four PVS patients were matched with 68 controls; 63% of patients (15/24) had prior GI pathology as opposed to 19% (13/68) of controls. The GI pathology group had a significantly higher growth restriction and C-reactive protein. The mean gradient across the pulmonary veins was higher in the gut pathology group versus controls, as was mortality (29% vs. 9%). Conclusions : The previously described association between PVS and intestinal pathology was further strengthened by this study. The presence of GI pathology should lead to early surveillance and intervention for PVS.
Acute hydrops as an atypical presentation of primary congenital glaucoma

Primary congenital glaucoma (PCG) is a disease of childhood characterized by elevated intraocular pressure (IOP) that causes stretching of the eye's outer coats, namely sclera and cornea. This results in the elongation of the eyeball and expansion of the horizontal corneal diameter giving the appearance of a buphthalmos eye. Aggressive disease with high IOP readings causes excessive mechanical stretching that may be poorly tolerated by the corneal Descemet's membrane, leading to large breaks in it with subsequent corneal edema due to sudden influx of the aqueous humor into the exposed stroma, resulting in acute corneal hydrops. While acute hydrops is a potential sequel of PCG, it is considered one of its rare presentations. We present two cases who presented to our hospital with acute hydrops secondary to PCG. Both patients were managed surgically where the first patient underwent combined trabeculotomy-trabeculectomy with mitomycin C, while the second patient underwent deep sclerectomy with mitomycin C. The surgical procedures effectively controlled the IOP and aided in clearing corneal edema in both patients. Early diagnosis and timely surgical intervention are of paramount importance to improve visual outcomes, enhance ocular maturation, and prevent potential irreversible vision loss, especially in this young-age group of patients that are prone to amblyopia.
In Vitro and In Silico Antistaphylococcal Activity of Indole Alkaloids Isolated from Tabernaemontana cymosa Jacq (Apocynaceae)

The species of the genus Tabernaemontana have a long tradition of use in different pathologies of infectious origins; the antibacterial, antifungal, and antiviral effects related to the control of the pathologies where the species of this genus are used, have been attributed to the indole monoterpene alkaloids, mainly those of the iboga type. There are more than 1000 alkaloids isolated from different species of Tabernaemontana and other genera of the Apocynaceae family, several of which lack studies related to antibacterial activity. In the present study, four monoterpene indole alkaloids were isolated from the seeds of the species Tabernaemontana cymosa Jacq, namely voacangine (1), voacangine-7hydroxyindolenine (2), 3-oxovoacangine (3), and rupicoline (4), which were tested in an in vitro antibacterial activity study against the bacteria S. aureus, sensitive and resistant to methicillin, and classified by the World Health Organization as critical for the investigation of new antibiotics. Of the four alkaloids tested, only voacangine was active against S. aureus, with an MIC of 50 μg/mL. In addition, an in silico study was carried out between the four isolated alkaloids and some proteins of this bacterium, finding that voacangine also showed binding to proteins involved in cell wall synthesis, mainly PBP2 and PBP2a.
Patient Satisfaction, Perception-expectation Gap, and Customer Satisfaction Index in Annual Survey 2021 at Dr. Soetomo General Academic Hospital, Indonesia

Service quality is essential in health institutions that can affect patient satisfaction and loyalty. The growth in the number of patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, triggered the diversification of services that require periodic quality control. This study aimed to investigate the performance of 31 departments/units in the hospital, the level of customer satisfaction with services provided, and factors that could influence satisfaction. A survey about service performance, perception, and expectation of services was carried out in 31 departments/units using questionnaires from August to October 2021. Convenient respondents consisted of 2121 patients and their families aged >15. Questionnaire items assessed performance, perceptions, and expectations of health services using the SERVQUAL method. Statistical Package for the Social Sciences (SPSS) software was used to perform an analysis of the results of the measurement and the difference in responses between demographic groups of respondents (p<0.05 was significant). The mean performance score was 92.86, and the gap between their perception and expectation averaged - 0.23. Customers' expectations of the provider's competence were met, and its performance was perceived to be the best. Meanwhile, handling complaints was perceived as having the lowest performance, while customers’ satisfaction over it had not been met. The results showed that the hospital could still not fully meet some of the customer expectations, with immediate improvements needed in handling complaints.
Mathematical Modelling and Avascular Tumour Growth ∗ Interdisciplinary Research

Neela Nataraj works in the broad research area of numerical analysis and is currently a Professor in the Department of Mathematics, IIT Bombay. She completed her PhD from IIT Delhi in 1998 and has been a faculty member in both IITD and IITB. Cancer is a global health burden; 1 in 2 people will be diagnosed with some form of cancer during their lifetime. In the Western world, 50% of cancer patients survive for 10 or more years after diagnosis, compared to 24% forty years earlier. Cancer can come in many different forms, but tissues affected by cancer tend to have common features such as abnormal cell growth rates. Cancer biology is incredibly complicated, as illustrated by the difficulties surrounding the diagnosis and treatment of cancer. However, mathematics has the potential to mediate this complexity by abstracting the system using simplifying assumptions into a mathematical framework that can be analysed and/or solved numerically to gain biological insight. This article is an introduction to the mathematical modelling of one of the important early stages of tumour growth – the avascular stage – where there is no blood supply to the tumour.
The COVID-19 Pandemic: Capital Importation to Banking Business

This paper investigated the decline of capital importation to Nigeria and specifically banking business in Nigeria in the pre-COVID-19 pandemic era and during the COVID-19 pandemic era. The investigation became necessary considering the high prevalence of the COVID-19 pandemic in most of the top countries with capital exportation into Nigeria and the sharp decline in the importation of capital. Bringing, liquidity and stability of the banking business into concern. Data on capital importation were extracted from the CBN Statistical Bulletin and analyzed using a test for equality of means with both the Anova and Welch F-tests. We found that there is statistically significant difference in the averages of the capital importation to the banking business and Nigeria as a whole between the two periods of concern. We recommend that this [the reduction in the capital importation] should be monitored intermittently to ensure survival, stability, liquidity and enhanced share premiums of the banks. Also, the regulating authorities should regulate towards promotion of liquidity and stability in the financial system by permitting certain policies to take effect, such as transforming from Plc. to HoldCo structure.
BTT_A_335697 67..83

Several biologic therapies have been approved for enteric diseases. We evaluate each biologic’s role based on their mechanism of action in treating these conditions. This review examines data on efficacy and safety, as well as considerations for using these therapies in clinical practice in inflammatory bowel diseases, enteric infections—specifically Clostridioides difficile colitis—and potentially in the increasingly prevalent disorder of eosinophilic esophagitis. When choosing an appropriate therapy, it is important to assess patient severity, as most biologics are approved for those with moderate to severe disease activity. With many years of data from clinical trials and real-world experience, these therapies have been shown to improve outcomes overall in enteric diseases, contributing to more options for our patients.
Deming's 14 Points for Management: Framework for Success

Dr W. Edwards Deming modestly describes himself as a 'consultant in statistical studies'. Others have called him the father of the third wave of the Industrial Revolution. It is now becoming widely accepted that the dramatic turnround in Japan's industrial fortunes dates from Dr Deming's visit, at the invitation of JUSE, in mid-1950. His philosophy combines widespread use of statistical ideas and methods throughout organisations with an approach to management which is, in most part, diametrically opposed to traditional and current practice in the Western world. The management approach creates an environment where the importance of statistical practice is recognised to an otherwise unprecedented extent. This approach is not normally taught in management and business schools, and so the statistical consultant, needs to become familiar with, and to encourage the adoption of, the management philosophy as much as the statistical aspects. In this paper, a summary of Dr Deming's crucial 14 Points for Management is presented, abstracted and adapted from a number of versions which have appeared over the years.
Summary We examined links between chocolate craving inpeoplewho are depressed andboth personality style and atypical depressive symptoms, with a web-based questionnaire completedby

between chocolate craving inpeoplewho are depressed andboth personality style and atypical depressive symptoms, with a web-based questionnaire completedby nearly 3000 individuals reportingclinical depression.Chocolatewas cravedbyhalf of the respondents (more so bywomen), judged as beneficial fordepression, anxiety and irritability, and associated specifically with personality facets encompassedby thehigher-order constructof neuroticism.The simple question of depression-associated chocolate cravingappeared an efficient discriminatorof DSM^IVatypical depression symptoms.
PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors

ABSTRACT PARP inhibitors are synthetically lethal with BRCA1/2 mutations, and in this setting, accumulation of DNA damage leads to cell death. Because increased DNA damage and subsequent immune activation can prime an anti-tumor immune response, we studied the impact of olaparib ± immune checkpoint blockade (ICB) on anti-tumor activity and the immune microenvironment. Concurrent combination of olaparib, at clinically relevant exposures, with ICB gave durable and deeper anti-tumor activity in the Brca1m BR5 model vs. monotherapies. Olaparib and combination treatment modulated the immune microenvironment, including increases in CD8+ T cells and NK cells, and upregulation of immune pathways, including type I IFN and STING signaling. Olaparib also induced a dose-dependent upregulation of immune pathways, including JAK/STAT, STING and type I IFN, in the tumor cell compartment of a BRCA1m (HBCx-10) but not a BRCA WT (HBCx-9) breast PDX model. In vitro, olaparib induced BRCAm tumor cell–specific dendritic cell transactivation. Relevance to human disease was assessed using patient samples from the MEDIOLA (NCT02734004) trial, which showed increased type I IFN, STING, and JAK/STAT pathway expression following olaparib treatment, in line with preclinical findings. These data together provide evidence for a mechanism and schedule underpinning potential benefit of ICB combination with olaparib.
Impact of COVID-19 Pandemic on Antimicrobial Resistance Pattern; Transition from Resistivity to Susceptibility

The study aimed to assess the antibiotic resistance pattern before and after the pandemic to provide the physicians with general guidance for antibiotic prescribing. The yearly antibiograms of different tertiary care hospitals were extracted from Pakistan Antimicrobial Resistance (AMR) Network. The data timeline observed was from January 2016 to December 2020. The data were scrutinized to the most common organism studied with the most recurring antimicrobial used. Among the Gram-positive organisms, increased resistivity against penicillin was observed against both the organism, while a good susceptibility was observed against vancomycin. Among the Gram-negative organisms, the highest resistance was observed in Ceftriaxone, Ciprofloxacin, and Cotrimoxazole. Staphylococcus aureus and Escherichia coli are the most prevalent organisms in tertiary care hospitals. While satisfactory susceptibility was observed in Amikacin and Piperacillin/Tazobactam. The post-pandemic era resulted in a decrease in AMR due to significant changes in antibiotic prescribing patterns. This report may guide future antibiotic prescribing.
Dysregulated Ca2+ Homeostasis as a Central Theme in Neurodegeneration: Lessons from Alzheimer’s Disease and Wolfram Syndrome

Calcium ions (Ca2+) operate as important messengers in the cell, indispensable for signaling the underlying numerous cellular processes in all of the cell types in the human body. In neurons, Ca2+ signaling is crucial for regulating synaptic transmission and for the processes of learning and memory formation. Hence, the dysregulation of intracellular Ca2+ homeostasis results in a broad range of disorders, including cancer and neurodegeneration. A major source for intracellular Ca2+ is the endoplasmic reticulum (ER), which has close contacts with other organelles, including mitochondria. In this review, we focus on the emerging role of Ca2+ signaling at the ER–mitochondrial interface in two different neurodegenerative diseases, namely Alzheimer’s disease and Wolfram syndrome. Both of these diseases share some common hallmarks in the early stages, including alterations in the ER and mitochondrial Ca2+ handling, mitochondrial dysfunction and increased Reactive oxygen species (ROS) production. This indicates that similar mechanisms may underly these two disease pathologies and suggests that both research topics might benefit from complementary research.
Efficacy of Digestive Endoscope Based on Artificial Intelligence System in Diagnosing Early Esophageal Carcinoma

Objective To explore the efficacy of digestive endoscopy (DEN) based on artificial intelligence (AI) system in diagnosing early esophageal carcinoma. Methods The clinical data of 300 patients with suspected esophageal carcinoma treated in our hospital from January 2018 to January 2020 were retrospectively analyzed; among them, 198 were diagnosed with esophageal carcinoma after pathological examination, and 102 had benign esophageal lesion. An AI system based on convolutional neural network (CNN) was adopted to assess the DEN images of patients with early esophageal carcinoma. A total of 200 patients (148 with early esophageal carcinoma and 52 with benign esophageal lesion) were selected as the learning group for the Inception V3 image classification system to learn; and the rest 100 patients (50 with early esophageal carcinoma and 50 with benign esophageal lesion) were included in the diagnosis group for the Inception V3 system to assist the narrow-band imaging (NBI) with diagnosis. The diagnosis results from Inception V3-assisted NBI were compared with those from imaging physicians, and the diagnostic efficacy diagram was drawn. Results The diagnosis rate of AI-NBI was significantly faster than that of physician diagnosis (0.02 ± 0.01 vs. 5.65 ± 0.32 s (mean rate of two physicians), P < 0.001); between AI-NBI diagnosis and physician diagnosis, no statistical differences in sensitivity (90.0% vs. 92.0%), specificity (92.0% vs. 94.0%), and accuracy (91.0% vs. 93.0%) were observed (P > 0.05); and according to the ROC curves, AUC (95% CI) of AI-NBI diagnosis = 0.910 (0.845-0.975), and AUC (95% CI) of physician diagnosis = 0.930 (0.872-0.988). Conclusion CNN-based AI system can assist NBI in screening early esophageal carcinoma, which has a good application prospect in the clinical diagnosis of early esophageal carcinoma.
Dependence of Body Mass Index on Some Dietary Habits: An Application of Classification and Regression Tree

Background: The purpose of this study was to determine the influence of some eating habits on body mass index (BMI) using a regression model created via the classification and regression tree method (CART). Methods: The study was conducted using a questionnaire specially developed for the study, evaluated for reliability and validity. In addition to demographics (age and sex), the questions concern the timing of the meals and the type of food consumed. The data contains records for 533 people (322 women and 211 men) aged 18 to 65 years. The survey was conducted in the period 2019–2021 in Stara Zagora, Bulgaria. Data were processed using descriptive statistics, and regression and classification data mining method CART. Results: A CART model with a dependent variable BMI and predictors Sex, Age, Breakfast type, Breakfast time, Lunchtime, Lunch type, Dinner time, Dinner type have been created. The obtained model is statistically significant at a significance level of P<0.0001 and a coefficient of determination R2 = 0.495. The normalized importance of the factors that affect the BMI is as follows: Sex (100%), Age (61.4%), Lunch type (26. 0%), Lunchtime (18.8%), Dinner time (13.9%), and Breakfast type (13.2%). Women have a lower BMI than men. BMI increases with age. Conclusion: The CART method allows to make a classification by the predictors used and gives opportunities for a more in-depth analysis of the reasons for the increase in BMI. The level of influence of diet and eating habits (type of food, time of consumption) on BMI was determined.
A Method for Predicting Pile Bearing Capacity From Dynamic Penetration Tests

This paper presents a new method for predicting the axial capacity of piles from dynamic penetration tests which is based on the concepts of soil dynamics and principles of energy conservation. The energy delivered to the hammerrod-sampler system and transferred to the soil is computed from the numbers of blow counts Nspt and is analytically converted in a penetration dynamic force. The dynamic force allows the unit resistance mobilized in the SPT sampler (model) to be determined, which is then used to predict the unit resistance mobilized in a prototype pile. The strong direct relationship between the ultimate resistance of driven steel piles and the SPT dynamic force, without any bias of soil type, validates the method. Extension of the method to other pile types requires empirical parameters to account for installation effects. Predictions of 89 instrumented static pile load test database demonstrate that the proposed methodology can be efficiently used in the assessment of axial pile capacity, providing a practical way of increasing reliability in pile design by accounting for effects controlling dynamic penetration.
HUBUNGAN POSISI KERJA DENGAN KELUHAN MUSKULOSKELETAL PADA UNIT PENGELASAN PT. X BEKASI

ABSTRACT This study was conducted to analyze the relation between body position with musculoskeletal complaints in welding unit of PT. X Bekasi. Welding is an important part of a steel fabrication company. Workers in the welding influenced by the position of work, the posture of their body of work and performance at work. Jobs that forced the labor to not an ergonomic posture when working cause workers had faster experience fatigue and indirectly provide additional workload. Health effects that arised as a result of an unergonomic worked postures are musculoskeletal disorders . This research is an observational research with cross sectional approach design. 32 workers were chosen as sample by using simple random sampling technique. Data were obtained by measuring, observing used Rapid Entire Body Assessment (REBA), and filling out questionnaire Nordic Body Map (NBM). Spearman rho correlation test was used to analyse the relation between variables. As many as 68.6% workers had a weak risk of having musculoskeletal disorder (REBA score of 4-7) and 62.5% workers had a weak level of musculoskeletal complaint. Based on the results of this study concluded that body position were significantly related to musculoskeletal complaints. There was a weak significant relationship between body position and musculoskeletal complaints (pvalue= 0.005). It is suggested to companies that provide training on ergonomic working position when welding perform. Keywords: Rapid Entire Body Assessment (REBA), Nordic Body Map (NBM), body position and musculoskeletal complaints