Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of Scientific Learning Model Based on Local Wisdom of "Piil Pesenggiri" to Improve Process Skills and Character Values of Elementary School Students

This study aims: to produce a learning model based on Local Wisdom Piil Pesenggiri knowledge that has characteristics that can improve the process skills and values of elementary school characters, produce a science learning model based on Piil Pesenggiri Local Wisdom based on appropriate knowledge to improve process skills and values of elementary school character, produce a model of science learning based on Piil Pesenggiri Local Wisdom which is effective for improving the process skills and characters values of elementary school. This research using the ADDIE step of the Research and Development method. The trial subjects included elementary school grade IV students in Lampung Province. Need assessment data is collected by interview, questionnaire, and observation. The feasibility data of the learning model were collected using a validation sheet questionnaire. Data were analyzed descriptively and statistically. This study's results are expected to make the model of learning science-based on local wisdom Piil Pesenggiri can lead to the development of a learning science model on local wisdom in other regions throughout Indonesia. This development is expected to help students be more interested in learning, understanding their own culture, and becoming students who have good character values.
Glucocorticoid Receptor β Isoform Predominates in the Human Dysplastic Brain Region and Is Modulated by Age, Sex, and Antiseizure Medication

The glucocorticoid receptor (GR) at the blood–brain barrier (BBB) is involved in the pathogenesis of drug-resistant epilepsy with focal cortical dysplasia (FCD); however, the roles of GR isoforms GRα and GRβ in the dysplastic brain have not been revealed. We utilized dysplastic/epileptic and non-dysplastic brain tissue from patients who underwent resective epilepsy surgery to identify the GRα and GRβ levels, subcellular localization, and cellular specificity. BBB endothelial cells isolated from the dysplastic brain tissue (EPI-ECs) were used to decipher the key BBB proteins related to drug regulation and BBB integrity compared to control and transfected GRβ-overexpressed BBB endothelial cells. GRβ was upregulated in dysplastic compared to non-dysplastic tissues, and an imbalance of the GRα/GRβ ratio was significant in females vs. males and in patients > 45 years old. In EPI-ECs, the subcellular localization and expression patterns of GRβ, Hsp90, CYP3A4, and CYP2C9 were consistent with GRβ+ brain endothelial cells. Active matrix metalloproteinase levels and activity increased, whereas claudin-5 levels decreased in both EPI-ECs and GRβ+ endothelial cells. In conclusion, the GRβ has a major effect on dysplastic BBB functional proteins and is age and gender-dependent, suggesting a critical role of brain GRβ in dysplasia as a potential biomarker and therapeutic target in epilepsy.
Nursing Students’ Experiences in Consecutive Clinical Interprofessional Education in Japan: Application of the IPE in Nursing Colleges

Aim: To document nursing students’ experiences of continuous participation in a clinical interprofessional education (IPE) program with the Faculty of Pharmacy of other universities in Japan, which had been incorporated into the existing practicum program, and consider how to develop a one-shot clinical IPE program. Methods: The study participants were two nursing students from a single-department college; they were participating in a clinical IPE program—the first IPE program they had ever participated in—during an area-based practicum in Year 3. Subsequently, in Year 4, a semi-structured interview was conducted, and these interview data were qualitatively and inductively analyzed. Results: Seven categories were identified, and it was found that through continuous participation in the IPE program, there was a change from “clinical IPE is stuck at the back of their mind as a bitter experience” to “the process of clinical IPE stimulates their maturity as a nursing student” and “cultivates attitudes necessary for cooperation”. Conclusion: Consecutive years of continuous clinical IPE helps students deepen their understanding of learning content by reducing the physical and mental burden of multidisciplinary cooperation and collaboration. For difficulties with regard to step-by-step IPE, it is suggested that one-shot clinical IPE can be conducted for the upper grades along with continuous reflection activities for teams and individuals.
Sensitivity analysis of the impact of Covid-19 on corporate sustainability and company performance

The study examined the sensitivity analysis of the impact of Covid-19 on Corporate Sustainability and Company Performance of South African listed companies. The study employed secondary data retrieved from the annual reports of the selected companies. Stakeholder Theory and the Traditional Theory of Economics and Finance from the theoretical foundation of this study. Data retrieved from 40 companies for the period 2010 -2021 was analyzed using panel fully modified ordinary least squares (FMOLS) and dynamic ordinary least square (DOLS) methods, representing all sectors with the help of a convenience sampling method. Findings revealed a strong relationship between corporate sustainability performance and company performance with other explanatory variables. This study also implied that the impact of the Covid-19 pandemic was so sensitive on South African companies and companies must pay strong attention to recovery strategies suggested to reduce the severity of the impact on them and ensure a quick recovery.
Association between pre-pregnancy multimorbidity and adverse maternal outcomes: A systematic review

Objective We reviewed the literature on the association between pre-pregnancy multimorbidity (co-occurrence of two or more chronic conditions) and adverse maternal outcomes in pregnancy and postpartum. Data sources Medline, EMBASE, and CINAHL were searched from inception to September, 2021. Study selection Observational studies were eligible if they reported on the association between ≥ 2 co-occurring chronic conditions diagnosed before conception and any adverse maternal outcome in pregnancy or within 365 days of childbirth, had a comparison group, were peer-reviewed, and were written in English. Data extraction and synthesis Two reviewers used standardized instruments to extract data and rate study quality and the certainty of evidence. A narrative synthesis was performed. Results Of 6,381 studies retrieved, seven met our criteria. There were two prospective cohort studies, two retrospective cohort studies, and 3 cross-sectional studies, conducted in the United States (n=6) and Canada (n=1), and ranging in size from n=3,110 to n=57,326,681. Studies showed a dose-response relation between the number of co-occurring chronic conditions and risk of adverse maternal outcomes, including severe maternal morbidity or mortality, hypertensive disorders of pregnancy, and acute health care use in the perinatal period. Study quality was rated as strong (n=1), moderate (n=4), or weak (n=2), and the certainty of evidence was very low to moderate. Conclusion Given the increasing prevalence of chronic disease risk factors such as advanced maternal age and obesity, more research is needed to understand the impact of pre-pregnancy multimorbidity on maternal health so that appropriate preconception and perinatal supports can be developed.
Surgical site infections: surgical reoperation and infection in clean and potentially contaminated surgeries

Objective: to verify the association between the occurrences of surgical site infection (SSI) and the need for re-approach in patients undergoing clean and potentially contaminated surgeries. Method: longitudinal study, involving 75 patients with infection; data collection was carried out using a survey form evaluating sociodemographic and clinical aspects. The association was assessed by the odds ratio and its confidence intervals (95%CI). Results: patients hospitalized for external causes are four times more likely to be surgically re-approached (p=0.011), in the orthopedic specialty the reason was five times greater (p=0.003), readmissions are 10 times more likely to be re-approached (p=0.000), leukocytosis (p=0.002) and alteration in the value of c-reactive protein (p=0.016) were associated with the need for a new surgery. Positive culture (p=0.001) and therapeutic antibiotic (p=0.04) proved to be protective factors for re-approach. Conclusion: the data demonstrate the presence of SSI as a strong influencer in surgical reoperation, guiding hospitals with the same profile. y potencialmente contaminadas. Método: estudio longitudinal, involucrando 75 pacientes con infección; la recogida de datos tuvo lugar en un formulario de investigación que evaluaba aspectos sociodemográficos y clínicos. La asociación se evaluó mediante odds ratio y sus intervalos de confianza (IC95%). Resultados: los pacientes hospitalizados por causas externas tienen cuatro veces más posibilidades de reoperación (p=0,011); en la especialidad de ortopedia, la proporción fue cinco veces mayor (p=0,003); los reingresos tienen 10 veces más posibilidades de reoperación (p=0,000); la leucocitosis (p=0,002) y la alteración en el valor de la proteína c-reactiva (p=0,016) se asociaron con la necesidad de nueva cirugía. La cultura positiva (p=0,001) y el antibiótico terapéutico (p=0,04) demostraron ser factores protectores para la reoperación. Conclusión: los datos demuestran la presencia de ISQ como una fuerte influencia en la reoperación quirúrgica, guiando a los hospitales con el mismo perfil.
T Follicular Helper Cells in Mice Signaling in Development and B Cell Help of A Regulatory Role for IL-10 Receptor

IL -10 is widely accepted as a survival, proliferation, and differentiation factor for B cells. However, IL-10 deﬁciency accelerates disease progression as the result of autoantibody production in many autoimmune disease models. It was demonstrated that T follicular helper cells (T FH cells) play a key role in helping B cells that are secreting Abs. In this study, we demonstrated a regulatory role for IL-10R signaling on the development and B cell help function of T FH cells in vitro and in vivo. IL-1R subunit b -deﬁcient ( Il10rb 2 / 2 ) Th cells were able to differentiate more readily into T FH cells, as well as secrete more IL-21 and IL-17 compared with wild-type Th cell-derived T FH cells. Increased IL-21 and IL-17 contributed to the enhanced B cell help functions of T FH cells. Further experiments demonstrated that IL-6 and IL-23 from dendritic cells in Il10rb 2 / 2 mice contributed to the differentiation of naive Th cells into T FH cells, as well as the generation of IL-21– and IL-17–producing T FH cells. Our results provide useful information for clarifying the immunoregulatory mechanisms associated with IL-10 deﬁciency in certain autoimmune disease models. This information could also be of beneﬁt for the development of vaccines. The Journal of Immunology , 2012, 189: 000–000.
Persistent neuropathological effects 14 years following amyloid- b immunization in Alzheimer’s disease

We performed a 15-year post-mortem neuropathological follow-up of patients in the ﬁrst trial of amyloid- b immunotherapy for Alzheimer’s disease. Twenty-two participants of a clinical trial of active amyloid- b 42 immunization (AN1792, Elan Pharmaceuticals) or placebo were studied. Comprehensive post-mortem neuropathological assessments were performed from 4 months to 15 years after the trial. We analysed the relationships between the topographical distribution of amyloid- b removal from the cerebral cortex and tau pathology, cerebrovascular territories, plasma anti-AN1792 antibody titres and late cognitive status. Seventeen of 22 (77%) participants had Alzheimer’s neuropathological change, whereas 5 of 22 (23%) had alternative causes for dementia (progressive supranuclear palsy = 1, Lewy body disease = 1, vascular brain injury = 1, and frontotemporal lobar degen-eration = 2). Nineteen of the 22 participants had received the active agent, three the placebo. Fourteen of 16 (88%) patients with Alzheimer’s disease receiving the active agent had evidence of plaque removal (very extensive removal = 5, intermediate = 4, very limited = 5, no removal = 2). Of particular note, two Alzheimer’s patients who died 14 years after immunization had only very sparse or no detectable plaques in all regions examined. There was a signiﬁcant inverse correlation between post-vaccination peripheral blood anti-AN1792 antibody titres and post-mortem plaque scores ( (cid:2) = (cid:2) 0.664, P = 0.005). Cortical foci cleared of plaques contained less tau than did cortex with remaining as
Title: Fishing for feed in China: facts, impacts and implications

: China is the world’s largest capture fisheries and aquaculture producer. Over recent decades, China’s domestic marine catch composition has changed markedly, from large volumes of a few high-valued food species to multiple, small, low-valued, species, a significant proportion of which is primarily used as animal, especially fish, feed. Despite the growing volume and economic importance of the feed catches, their species composition, catch volumes and socio-environmental impacts are all poorly understood. Based on a nationwide survey of >800 fishing vessels, and the identification and measurement of >12,000 fish and invertebrate individuals, the present study provides an overview of the feed component of China’s domestic marine catch, by volumes, species, and sizes, and found it to be substantial and biologically unsustainable. Half of the trawler catch (3 million metric tons, mmt), or 35% of the total catch (4.6 mmt) in China’s exclusive economic zone are now comprised of low-valued ‘feed grade fish’. The present study identified 218 fish species, 50 crustaceans and five cephalopods and of these, 102 fish species were food species with 80% in their juvenile size ranges. Feed grade fish were mainly used as aquaculture feed directly, or indirectly through the feed industry after reduction to fishmeal and fish oil. The unparalleled scale and poor fisheries resource condition of China’s domestic marine fisheries, in parallel with severe overfishing of juveniles, creates a demand for fundamental changes to fishery management practices, including a significant reduction of fishing effort to ensure productivity and ecosystem resilience.
The Analysis on the Influence of Foreign Direct Investment (FDI) on Total GDP at ASEAN

: This study aims to analyze the effect of FDI on the gross domestic product (GDP) growth rate in ASEAN countries using the panel data method during the period of 2007-2016. This study uses ordinary methods least square (OLS). To estimate it used three models of approaches, namely common effect model (CEM), fixed effect model (FEM) and random effect model (REM). After the Chow test and Hausman test, the best model was obtained as a random effect model (REM). The results of the study show that the FDI (Foreign Direct Investment) has a positive impact on the GDP (Gross Domestic Product) growth in ASEAN.
RURAL YOUTH EMPLOYMENT IN AFRICA: AN EVIDENCE REVIEW

This report evaluates the potential of the rural economy to provide decent employment and the outcomes associated with various types of employment for rural young people in Africa. The review draws on elements of the landscapes of rural youth opportunity framework, such as the importance of economic geography and local or regional contextual factors, in order to understand the available livelihood opportunities for rural African youth. Primarily, however, the review bases its analysis on the concept of structural transformation in order to determine the areas of the rural economy which can best provide decent employment opportunities for rural youth. This is amidst an ongoing global pandemic, which the Ilo has estimated to have particularly impacted 1.6 billion informal economy workers around the world, a large number of which are young Africans (Ilo, 2020b; Ilo, 2021).
Integration of embodied conversational agents and pecuniary traits in usability design for financial services applications

There is a great a need as ever for practical Human-Computer Interaction (HCI) research within the field of financial services due to the increased levels of switching behaviour exhibited by customers as well as possible competitors, pushing banks to provide a modern, flexible and personal service. As a result a much greater focus has been placed on Customer Relationship Management (CRM) over recent years. These factors have led to a large body of research much of which has highlighted the importance of investigating in new user interfaces and distribution channels that can effectively communicate with the customer, as well as delivering new and innovative
A 5-year review of incidence, presentation and management of Bartholin gland cysts and abscesses in a tertiary hospital, Yenagoa, South-South Nigeria

Background: Bartholin gland cysts and abscesses are common in women of reproductive age and declines after menopause. Organisms implicated in Bartholin abscess include, Neisseria gonorrhoeae, Chlamydia trachomatis, Escherichia coli, Staphylococcus aureus and Bacterioides spp. Aim: To determine the incidence, presentation and management of Bartholin gland cysts and abscesses at the Federal Medical Centre, Yenagoa, Bayelsa State, South-South Nigeria, over a five-year period. Settings and Design: This retrospective study was conducted in the Gynaecological Unit of the Federal Medical Centre, Yenagoa, Bayelsa State, South-South, Nigeria, between January 1, 2016 and December 31, 2020. Materials and Methods: Relevant data were retrieved, entered into a pre-designed proforma, and analysed. Statistical Analysis: Statistical Package for the Social Sciences version 25.0 was used for data analysis. Results were presented in frequencies and percentages for categorical variables. Results: There were 2,478 gynaecological cases managed in our Centre; out of which there were 26 cases of Bartholin cyst and abscess, giving an incidence of 1.05%. Most of the women were [≤] 30 years (14, 53.8%), single (17, 65.4%), nulliparous (13, 50.0%), traders (11, 42.3%), with only primary/secondary education (18, 69.2%). The left Bartholin gland was the most frequently affected (17, 65.4%). A positive microbial culture was obtained in 84% of cases, with Staphylococcus aureus and Escherichia coli being the isolated organisms. Marsupialisation was the treatment modality in all the patients. Conclusion: Women of reproductive age-group should be counselled on this condition and encouraged to keep good perineal hygiene and better sexual conduct so as to reduce the risk of Bartholin cysts and abscesses. Keywords: Bartholin gland, Cyst, Abscesses, Reproductive age, Marsupialisation.
Advances in Decision Analysis: Building Decision Competency in Organizations

Decision Analysis was introduced about forty years ago. Since that time the practice of decision consultants, whether internal or external to organizations, has expanded from analytical support in difficult decisions to designing governance and decision systems, and transforming enterprise capabilities. Organizations realize a significant positive impact when they develop true decision competency – that is, when high quality decision-making becomes part of their organizational DNA. In this chapter, the author first defines organizational decision competency and then describes how to achieve this competency. He describes two cases of two large corporations that have achieved a high level of decision competency. He concludes with a perspective on the first forty years of corporate adoption of decision competencies that still has a long way to go. Advances: Building Decision Competency Page 2 to 31 Ch 22 060506 V4 CONTENTS Background What is Organizational Decision Competency? Defining a Standard for High Quality Decisions Identifying Decision Team Roles Five Means for Achieving Organizational Decision Competency The Journey to Organizational Decision Competency The Current State of Adoption GM’s Road to Decision Competency Longstanding Practices and Culture Introducing the Decision Dialog Process Chevron Decision-Making in a High Uncertainty Business Conclusion Advances: Building Decision Competency Page 3 to 31 Ch 22 060506 V4
SOME PITFALLS OF SHORT-RANGE STANDARD-TARGET CALIBRATION

Often it is necessary or desirable to perform a standard-target calibration at rather short range, for example, because of shallow water or interest in measuring animals at short range. A number of general range-dependent effects may prove especially troublesome at short range. These include effects connected with (1) time-varied gain or similar range compensation, (2) finite size of the target, and (3) pulse repetition frequency. The origins of these effects are reviewed and, where particular to a· spepd.fi. c. · system,. illusrtr.zated . by reference· to the SIMRAD EK500 echo sounder.
Relationship Expectations, Behavior Interactions and Commitment: A Dyadic Study Among Dual-Earner Couples

Previous researchers have analyzed the links between relationship expectations and commitment in cohabiting and married couples. The present study examines a dyadic model where couple’s reported behavior interactions (RBI) are suggested as potential mediators and Work-Family Conflict (WFC) as a moderator. The association among these variables was tested by recruiting 111 (N = 222) dual-earner couples to complete questionnaires. To examine the dyadic model, we used the Actor-Partner Interdependence Model on the hypothesized model. The results showed that actor’s RBI was seen as a significant mediator of the associations between relationship expectations and both partner’s commitment. The partner’s affective behavior interactions emerged as a significant mediator between the actor’s expectations-actor’s commitment link but not with the partner’s commitment. In addition, actor’s WFC significantly moderated the effect of partner’s RBI on their commitment. These findings extended our knowledge of possible factors that play a role in promoting relationship commitment among dual-earners couples in long-term relationships. Through the integration of the Investment Model this study illuminates the pathways by which relationship expectations affect commitment via RBI of married and cohabiting couples. Furthermore, the study elucidates the behavioral component of cohabiting couples in long-term relationships from a dyadic perspective. From a practical perspective, clinicians and counselors working with couples experiencing relational difficulties, may want to inquire as to their clients’ relationship expectations and behavior interactions for better understanding commitment among couples.
Canine intracranial meningioma with rosette-like collagen deposits

A 13-year-old female Miniature Dachshund showed seizures and an intracranial mass was seen in the left temporal lobe. Three months after first surgical resection, a recurrence lesion was recognized. Histopathologically, proliferation of spindle cells with diffuse rosette-like eosinophilic deposits, which stained blue with Masson’s trichrome stain, was observed. In electron microscopy, the rosette-like deposits were consisted of bundles of minute filaments which were assumed to be collagenous fibrils. Immunohistochemically, the neoplastic cells were positive for vimentin and cytokeratin, and negative for E-cadherin, S100, glial fibrillary acidic protein (GFAP), oligodendrocyte transcription factor (Olig2), and CD204. The rosette-like collagen deposits were positive for type 4 collagen and negative for type 1 collagen. In this report, we describe histopathological features of a canine meningioma with the rosette-like collagen deposits.