Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and treatment outcome of DOTS in RNTCP

Retrospective observation analysis was carried out to evaluate the outcome of DOTS under RNTCP at NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital Digdoh Hills Hingna Nagpur tertiary care center . Total 141 patients were studied under all the categories registered from October 2006 to February 2008 with a follow up of one year . Standard norms were applied for treating and registering under different categories and for outcome of treatment. Category 1 consisted of 96 patients category 2 constituted 12 patients and category 3 had 33 patients. All patients were closely followed up during treatment phase and were asked for a regular follow up after completion of treatment. Of the 141 patients 94.33% patients were declared cured/ treatment completed, 3.54% defaulted, the failure rate was 1.418% and overall death rate was 2.128%. The cure / treatment completion in present study is 97.67% and 75% for new smear positive and pretreatment patients. Success rate in terms of cure/ treatment completion is much higher in category 1 patients and slightly higher in category 2 patients as compared to the national average of 86.50% and 70.5% in new smear positive and retreatment cases respectively . This was comparable to the other studies published earlier . Keywords: DOTS, RNTCP , Outcome, Enhanced.
A comparison of temperament and character among psychiatry, internal medicine, and surgery residents at Iran University of Medical Sciences in the academic year 2013–2014

Background: This study was conducted to compare temperament and character among psychiatry residents, internal medicine, and surgery residents in hospitals affiliated to Iran University of Medical Sciences in the academic year 2013–2014. Methods: This cross sectional analytical study was conducted on 201 residents using the non-probability method of convenience sampling. Cloninger’s 125-item Temperament and Character Inventory (TCI) and Maslach’s Burnout Inventory (MBI) were distributed among all the residents in their morning session. Once the questionnaires were completed and submitted, the data were analyzed in SPSS 16. The frequency of different personality traits was analyzed among the selected residents. Results: A total of 49.8% of the respondents were female (n=100) and 50.2% were male (n=101). The results of data analysis showed more novelty seeking, reward dependence, and harm avoidance and less persistence (33.93, p=0.006; 9.00, p=0.056; 32.55, p=0.021; and 2.48, p=0.028, respectively) in psychiatry residents than in surgery residents (31.97, 7.87, 30.74, and 3.12 respectively). Reward dependence was more frequent in internal medicine residents than in surgery residents (9.44 and 7.87 respectively, p=0.002). The self-directedness score was lower in psychiatry residents than in internal medicine residents (p=0.761) and higher than in surgery residents (17.96, 18.30, and 17.57 respectively, p=0.824). The cooperativeness and self-transcendence scores were higher in psychiatry residents than in internal medicine (p=0.943, p=0.199, respectively) and surgery residents (p=0.105, p=0.069 respectively). Conclusion: The different dimensions of personality varied between the surgery, internal medicine, and psychiatry residents. Particularly, this study did not show statistically significant differences in dimensions of character (cooperativeness, self-directedness, and self-transcendence) among surgery, internal medicine, and psychiatry residents. The selection of medical specialties based on character traits significantly contributes to more effective treatment of patients and higher satisfaction of the residents.
Association of CSF α-synuclein and tau protein concentrations with amyloid mean cortical standard uptake value ratios in preclinical subjective memory complainers stratified by Alzheimer’s disease biomarkers: the INSIGHT-preAD study

Alpha-synuclein (α-syn) plays a key role in regulating the synaptic vesicles pool size, trafficking, and membrane dynamics. Misfolded forms of α-syn undergo post-translational modifications showing high tendency towards aggregation and deposition into insoluble inclusion bodies, Lewy bodies (LB). Several brain proteinopathies with neurodegeneration, including Alzheimer’s disease (AD), typically exhibit deposition and spreading of LB in a prion-like fashion. Studies performed to assess α-syn diagnostic accuracy in cerebrospinal fluid (CSF) have reported a trend towards increased CSF α-syn concentrations in AD versus other neurodegenerative diseases (ND) and healthy controls (HC). The potential role of CSF α-syn in asymptomatic subjects at risk of AD has not been explored. We performed a cross-sectional study in a large-scale monocentric preclinical at risk cohort (INSIGHT-preAD). We found a positive association between CSF α-syn concentrations and amyloid mean cortical standard uptake value ratios (SUVR), even after adjusting for confounders. There were positive associations of CSF α-syn and CSF t-tau and p-tau181 proteins. Furthermore, we found a trend to statistical significance of increased CSF α-syn concentrations in Aβ PET-positive compared with Aβ PET-negative subjects. Animal models have shown that α-syn may synergistically and directly induce fibrillization of both tau and Aβ. Therefore, the main findings of this study indicate an association of CSF α-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease. Longitudinal studies with larger sample size are needed to assess whether increased CSF αsyn concentrations could depict longitudinal trajectories of asymptomatic subjects at risk for AD.
Expansion of Horizontal Wellbore Stability Model for Elastically Anisotropic Shale Formations With Anisotropic Failure Criteria: Permian Basin Case Study

The analytical wellbore stability model proposed in this study allows for a more accurate calculation of the safe drilling window for horizontal wells drilled in anisotropic shale formations. The stress distributions around the horizontal wellbore, based on Green and Taylor equations for stress concentrations around holes in elastically orthotropic plates, are compared with the result from the traditional Kirsch equations. The comparison reveals that the elastic anisotropy of shales induces larger magnitudes of tangential stress concentrations at the potential shear and tensile failure locations, i.e. π/2 or 0 from the maximum in-situ stress direction. The anisotropic wellbore stability (WBS) model is expanded with a failure criterion that accounts for the anisotropy of shale. The critical stresses for the safe drilling window depend on (1) the anisotropy of the in-situ stress conditions, (2) the elastic anisotropy of the local formation, and (3) local strength anisotropy, due to anisotropy of the shale fabric. The model can be practically applied in real-time wellbore stability analyses, to determine the stress concentrations and trajectories near the wellbore, as well as for calculation of the safe drilling window. Two case study wells for the Permian Basin (West Texas and New Mexico) are included in our study.
THREE-DIMENSIONAL SEISMIC TOMOGRAPHY AT THE GEYSERS GEOTHERMAL FIELD, CA, USA

Three-dimensional Vp/Vs-ratio structure is presented for The Geysers geothermal field using seismic travel-time data. The data were recorded by the Lawrence Berkeley National Laboratory (LBNL) using a 34-station seismic network. Results for the year 2011 indicate low Vp-Vs-ratios in the central section of The Geysers within and below the current reservoir. The extent of the Vp/Vs anomaly deceases with increasing depth. Spatial correlation with microseismicity, used as a proxy for subsurface water flow, indicates the following. Swarms of seismicity correlate well with areas of higher Vp/Vs estimates, while fewer events are located in region of low Vp/Vs estimates. This result supports past observations that high and low Vp/Vs-ratios are related to water and gas saturated zones, respectively. Furthermore, it is observed that Vp/Vs is inversely correlated to Vs but uncorrelated to Vp, leading support to laboratory measurements on rock samples from The Geysers that observe an increase in shear modulus while the core samples are dried out.
www.econstor.eu Supply Chain Dynamics With Assortative Matching

This paper studies the evolutionarily stable strategies of one-manufacturer and one-retailer supply chains. Each manufacturer and retailer chooses between two pure strategies of management: shareholder-oriented or stakeholder-oriented. Based on its management strategy, the firm decides its wholesale or retail price. In this paper, we consider supply chains formed by two matching processes: random matching and assortative matching. Our results indicate that random matching does not support interior Nash equilibria; the evolutionarily stable strategy is for both manufacturer and retailer to choose shareholder strategy. We extend Bergstrom (2003) to a two-population game, and compare the dynamics of supply chains under random matching and assortative matching. Interior Nash equilibrium is observed with assortative matching. However, this interior equilibrium is unstable. The four unique strategy profiles obtained by various combinations of the two strategy choices may be evolutionarily stable for certain values of the indices of assortativity.
Relationship of internet gaming disorder severity with symptoms of anxiety, depression, alexithymia, and aggression among university students

How to cite this article: Evren C, Evren B, Dalbudak E, Topcu M, Kutlu N. Relationship of internet gaming disorder severity with symptoms of anxiety, depression, alexithymia, and aggression among university students. Dusunen Adam The Journal of Psychiatry and Neurological Sciences 2019;32:227-235. Relationship of internet gaming disorder severity with symptoms of anxiety, depression, alexithymia, and aggression among university students
Intrinsic Formation and Macroscopic Interven- tion in Multi-agent Systems

In this dissertation, we study two problems within the field of the multiagent systems theory. One is the formation control for multiple reduced attitudes, which are extensively utilized in many pointing applications and under-actuated scenarios for attitude maneuvers. In contrast to most existing methodologies on the formation control, the proposed method does not need to contain any formation errors in the protocol. Instead, the constructed formation is attributed to geometric properties of the configuration space and the designed connection topology. We refer to this type of formation control as intrinsic formation control. Besides, the control protocols proposed in this work are designed directly in space S , avoiding to use any attitude parameterizations. Moreover, along the studies, some elementary tools for reduced attitudes control are developed. Another problem is a moment-based methodology to modeling and analyzing collective behavior of a group of agents. The theory is applicable for a wide range of applications, such as multi-agent systems with interactions as well as with leaders and/or control input, and the use of this framework can considerably reduce the computational burden for controlling and analyzing such systems. We therefore propose to develop and use this theory for the multi-agent applications such as crowd dynamics, opinion dynamics and other macroscopic problems. Particularly, in paper A a continuous control law is provided for a reduced attitude system, by which a regular tetrahedron formation can achieve asymptotic stability under a quite large family of gain functions in the control. Then, with a further restriction on the control gain, almost global stability of the tetrahedron formation is also obtained. In this work, we introduce a novel coordinates transformation that represents the relative reduced attitudes between the agents. The proposed method is an intrinsic formation control that does not need to involve any information of the desired formation beforehand. Another virtue of the method proposed is that only relative attitude measurement is required. Paper B further concerns the formation control of all regular polyhedral configurations (also called Platonic solids) for reduced attitudes. According to the symmetries possessed by regular polyhedra, a unified framework is proposed for their formations. Via using the coordinates transformation previously proposed, it is shown that stability of the desired formations can be provided by stabilizing a constrained nonlinear system. Then, a methodology to investigate the stability of this type of constrained systems is also presented. In paper C, we introduce an approach for modeling collective behavior of a group of agents using moments. We represent the swarming via their distribution and derive a method to estimate the dynamics of the moments. We
ECONOMICS WORKING PAPER SERIES IDENTIFYING MULTILATERAL DEPENDENCIES IN THE WORLD TRADE NETWORK

When studying the formation of trade between two countries, traditional modeling has described this decision as being primarily dependent on characteristics of the two trading partners. It is likely the case, however, that this decision to trade is dependent not only on the two countries involved but on the patterns by which all partners trade with one another. Standard efforts to control for these higher level dependencies such as the inclusion of multilateral resistance measures provide only a blunt reflection of these dependencies and neglect valuable information that the global trade network contains. This paper proposes the explicit incorporation of higher level dependencies in traditional modeling frameworks. Two network-based, gravity-inspired approaches are considered–a probit model of trade incidence and an exponential random graph model. Each approach uses the structure of the entire world trade network to explain the formation of trade between individual of countries. The use of exponential random graph modeling techniques (ERGM) in particular, which have largely been unexplored in economics, provides a powerful yet flexible framework with which to model and estimate bilateral trade in a way that allows for the identification of a wider variety of multilateral dependencies and a deeper consideration of the patterns that emerge in the world trade network. Using a standard gravity data set, a series of probit and ERGM estimations are conducted for observed world trade networks. The results from these models provide strong evidence that higher level dependencies are present in international trade and that ERGM analysis represents an effective modeling environment in which to study them. JEL Classification: F14, D85 Peter R. Herman Research Division Office of Economics U.S. International Trade Commission peter.herman@usitc.gov
Engaging with Natural Beauty May Be Related to Well-Being Because It Connects People to Nature: Evidence from Three Cultures

Connecting with nature has been described by some as an important psychological need. Indeed, research shows that a strong connection to nature predicts flourishing across a wide range of well-being indices. Engaging with natural beauty may be one route by which people satisfy this presumed need to connect with nature. Based on this reasoning, the purpose of the current research was to investigate whether nature connectedness mediates the relationship between engagement with natural beauty (i.e., the tendency to notice and be moved by beauty in nature) and well-being in three different cultures. Four cross-sectional surveys involving Canadian, Japanese, and Russian undergraduate students were conducted (N = 1,390). Engagement with natural beauty and nature connectedness were positively associated with a variety of well-being measures. Moreover, we found relatively consistent support for the indirect effect of nature connectedness in explaining the relationship between engagement with natural beauty and well-being. This finding replicated across five different measures and indices of well-being, two different measures of nature connectedness, and three different cultures. Overall, this research suggests that engaging with natural beauty may have an impact on well-being by promoting a stronger subjective connection with nature.
Sovereign risk contagion in the Eurozone: a time-varying coefficient approach

This paper analyzes sovereign risk contagion in the Eurozone using an extension to the canonical model for contagion proposed by Pesaran and Pick (2007) and Metiu (2012) to allow for time-varying coefficients. This becomes necessary due to changes in the risk pricing of sovereign bonds since the onset of the recent crisis period and due to the presence of contagion in typically bounded time intervals. Controlling for changes in the risk pricing by investors, we detect several channels of pure contagion between 2008 and 2012. Further, we find that the bailout-programs for Greece, Ireland and Portugal led to a disruption in contagion of sovereign risk from these countries to Spain, Italy, France and Belgium as was desired by policymakers. For all countries considered, we observe an increase in the relevance of general risk aversion towards sovereign debt since May 2010. This development partially replaced the significance of country-specific credit risk factors in explaining bond yield spreads. Our model extension yields a device that is suitable to determine whether policy interventions are required and to judge their success ex-post. JEL Classification: C32; E44; F34; G01; G15.
Predicting origami-inspired programmable self-folding of hydrogel trilayers

Imitating origami principles in active or programmable materials opens the door for development of origami-inspired self-folding structures for not only aesthetic but also functional purposes. A variety of programmable materials enabled self-folding structures have been demonstrated across various fields and scales. These folding structures have finite thickness and the mechanical properties of the active materials dictate the folding process. Yet formalizing the use of origami rules for use in computer modeling has been challenging, owing to the zero-thickness theory and the exclusion of mechanical properties in current models. Here, we describe a physics-based finite element simulation scheme to predict programmable self-folding of temperature-sensitive hydrogel trilayers. Patterning crease and assigning mountain or valley folds are highlighted for complex origami such as folding of the Randlett’s flapping bird and the crane. Our efforts enhance the understanding and facilitate the design of origami-inspired self-folding structures, broadening the realization and application of reconfigurable structures.
www.econstor.eu UNION INSTABILITY AND FERTILITY: A MICROSIMULATION MODEL FOR ITALY AND GREAT BRITAIN

Family dynamics are changing in Europe, but only few studies investigate how cohort completed fertility is affected by partnership behaviours and how this has changed over time. We use microsimulation techniques to investigate the effect of the increasing prevalence of union dissolution on completed fertility levels in Italy and Great Britain, two countries with very different systems of value. We find that the net effect of union instability is to decrease fertility (by about 0.5 children for Italian and 0.2 to 0.4 children for British cohorts) but the magnitude of the difference depends on the timing of union formation and separation. As expected, re-partnering produces more children in new partnerships if the separation occurs earlier. Nonetheless, it is only if separation takes place after the second birth and if all women re-partner that additional childbearing would almost compensate for births lost due to union disruption.
Industry Conditions and CEO Labor Markets *

We study the role of industry conditions in the labor market for CEOs in a sample of over 60,000 firm-years from 1990-2007. We find that CEOs are evaluated using relative-to-industry stock performance in both the external and internal labor markets. Future job prospects of CEOs who separate from an employer are dependent on relative-to-industry performance, but not on absolute industry performance, suggesting that new employers fully filter out industry performance in the evaluation of managerial talent. In the case of internal CEO turnover, we detect no independent role for industry stock returns in predicting turnover, but we do detect a significant role for industry accounting performance. Poor industry conditions are associated with more outside-the-firm hiring, but less outside-the-industry hiring conditional on hiring outside of the firm. These two effects approximately offset, and thus industry conditions play no net role on the industry-experience mix of new firm leaders. These findings have important implications for our understanding of managerial labor markets and the purported failure of the relative-performance-evaluation hypothesis to explain CEO turnover. JEL Classification: G30; G31; G32
SÉRIE SPÉCIALE p-ADIQUE ET COHOMOLOGIE ÉTALE COMPLÉTÉE par

Résumé. — Soit f une forme modulaire parabolique nouvelle de poids k ≥ 2 sur Γ0(Np) avec (N, p) = 1 vecteur propre des opérateurs de Hecke. Soit E une extension finie de Qp contenant les valeurs propres. Si k > 2, on montre que l’adhérence de la représentation Symk−2E2 ⊗ πp(f) de GL2(Qp) dans le complété p-adique lim ←−n lim −→r H (Y (Np),Z/pZ)⊗E détermine l’invariant L de f , c’est-àdire la restriction à Gal(Qp/Qp) de la représentation galoisienne p-adique associée à f . En utilisant des résultats de Colmez, on donne une description explicite de ce qu’est cette adhérence. Le cas k = 2 se comporte différemment, mais on montre comment on peut encore retrouver l’invariant L, du point de vue GL2(Qp), dans le complété p-adique précédent.
Antibiotic Development and Clinical Utilization; A Reality Check

The global significance of Antimicrobial Resistance (AMR) has been recognized by several bodies including the United Nations and World Health Organization [1,2]. In fact, the medical profession has been alerting us for almost 20 years with the IDSA coining the term “bad bugs no drugs” [3]. The pharmaceutical industry has had a mixed response to the situation. Several multinational companies have simply walked away from antibiotic research and development so the small, often single drug program, firms have tried to fill this major and growing gap. It is true that there have been no new drug classes for about 20 years and that the new candidate drugs are simply extensions of what we already have. This is largely correct but some new drugs have the potential to be “game-changers”.
Optics of the offshore Columbia River plume in spring-summer

: 2282 Optics of the offshore Columbia River plume in spring-summer Gonzalo S. Saldías*, R. Kipp Shearman, John A. Barth, Nicholas Tiffilaro, Curtiss O. Davis College of Earth, Ocean, and Atmospheric Sciences, Oregon State University, Corvallis, Oregon. * gsaldias@coas.oregonstate. edu
An Approach to Professional Ethics Education for Pre Service Teachers

Literature shows teachers face ethical quandaries bombarding them every day in their professional life. Reports reveal unprofessional behaviour among teachers. To adequately deal with these challenges teachers must get trained in professional ethics. However, evidences suggest inadequate attention paid to ethics training in teacher education programs. The present paper makes an attempt to study professional ethics, its early habituation and proposes an improved case analysis as a suitable approach for delivering training in professional ethics tailored to teaching practices.