Miracle-dz/UniFAR-FTUs huggingface dataset:
PERFORMANCE OF ONE-WAY REINFORCED CONCRETE WALLS SUBJECTED TO BLAST LOADS

The performance of one-way reinforced concrete walls in resisting blast loads is numerically evaluated in this paper. Reinforced concrete wall strips of dimension 4.0 × 1.0 m and different thicknesses and supported on two sides spanning in the long direction are subjected to blast loads produced by the detonation of high explosive charges. The modelling and analysis was carried out using ANSYS AUTODYN solver. The accuracy of the modelling and its parameters is numerically verified against published experimental results of blast load tests on reinforced concrete slabs. The model was capable of simulating the observed damage and displacement with reasonable accuracy. The verified model is then used for extensive parametric study to examine the effect of different design parameters on the performance of reinforced concrete walls under the effect of blast loads. The design parameters considered in this study include the effect of concrete compressive strength of RC wall, the wall thickness, the reinforcement amount and details, and reflected peak pressure. The wall performance was evaluated considering maximum displacement, extent of damage and energy absorbed within the wall through damage.
Effects of farmland consolidation in southern China on wild bee species composition, nesting location and body size variations

Traditional smallholding‐dominated agricultural landscapes in Southern China are increasingly homogenized and consolidated, resulting in large mono‐cropped fields and impoverished pollinator communities. The exact impact of this farmland consolidation on composition and functional traits of wild bee communities remains poorly understood. We studied these communities and functional traits in oilseed rape fields embedded in 18 agricultural landscapes located in Jiangxi Province, China, with 11 sites representing traditional (pre‐consolidation) and the remaining 7 sites consolidated agricultural landscapes. The composition of wild bee assemblages was not differentiated into consolidated and traditional farmland communities. The mean body size of wild bee species similarly did not shows significant differences between consolidated and traditional farmland. The mean intraspecific body size for a dominant species, Lasioglossum proximatum, was larger in consolidated than traditional farmland, while individuals of co‐dominant Eucera floralia showed no such differentiation. In consolidated farmland, the proportion of semi‐natural habitat was positively linked to the abundance‐based average interspecific body size of wild bee species. For abundance‐based calculations, the proportion of aboveground nesting bee species was lower in consolidated landscapes than in traditional ones. Our study suggests that farmland consolidation might affect intraspecific composition, particularly in abundant small‐bodied species. Above‐ground nesting bees may require specific management interventions in consolidated agricultural landscapes to promote their persistence, which could take the form of semi‐natural habitat patches introduced to fields that can also benefit the pollinator community more widely.
Correlation of Serum Homocysteine Levels and Hyperinsulinaemia with Body Mass Index in Polycystic Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting women in reproductive age group. The interrelationship of serum homocysteine, homoeostatic assessment of insulin resistance (HOMA-IR) and body mass index amongst overweight, obese and non-obese PCOS patients is not fully established. Aims: We aimed to study the correlation of serum homocysteine levels and hyperinsulinaemia with body mass index (BMI) in PCOS patients. Study Setting and Design: This was a case–control study in which 35 women with PCOS and 35 non-PCOS women acting as controls were enrolled. Materials and Methods: Cases were identified by Rotterdam's criteria. (IR) indices, HOMA determination and serum homocysteine levels were determined and their correlation with BMI was studied. Statistical Analysis Used: Student's t-test and analysis of variance test were used for statistical analysis. The Pearson correlation coefficient was then used to estimate the correlation. Results: On overall evaluation, a significant positive correlation of fasting insulin, HOMA-IR and serum homocysteine) was observed (P < 0.05), however, on evaluating the correlation of these markers independently in cases and controls, only fasting insulin and HOMA-IR showed a significant correlation. In a multivariate model where PCOS was considered a dependent variable with age, fasting glucose, HOMA-IR, serum homocysteine and body mass index as the independent variables, only serum homocysteine levels were found to be significantly associated with the dependent variable (odds ratio = 1.172; 95% confidence interval = 1.032–1.330). Conclusion: PCOS women had significantly higher mean fasting glucose, fasting insulin, HOMA-IR and homocysteine levels as compared to non-PCOS controls. Mean HOMA-IR, homocysteine and fasting insulin levels showed a significant incremental trend with increasing BMI category in overall evaluation as well as in cases and controls independently.
Efficacy and Safety of Intravitreal Fluocinolone Acetonide Implant for Chronic Diabetic Macular Edema Previously Treated in Real-Life Practice: The REALFAc Study

Diabetic macular edema (DME) is the main cause of visual impairment in diabetic patients and a chronic disease requiring long-term treatments. The fluocinolone acetonide (FAc) implant has recently been approved to treat DME in patients considered insufficiently responsive to available therapies. This study evaluates the functional and anatomical efficacy of the FAc implant in real-life practice. A total of 62 eyes with chronic DME were included and followed for a mean of 13.9 (+7.5) months. Previous treatment included at least anti-vascular endothelial growth factor (VEGF) in 83.9% of eyes, dexamethasone implant (DEX-I) in 100% of eyes, vitrectomy in 29.0% of eyes, and laser photocoagulation (either panretinal or focal photocoagulation) in 75.8% of eyes. The mean baseline best corrected visual acuity (BCVA) was 64.0 (+/−17.2) letters (median: 67.5 letters) with a mean DME duration of 60.3 (+/−30.6) months. The maximum BCVA gain occurred at 21 months with a mean gain of 5.0 (+/−12.7) letters. A total of 50.0% of eyes gained ≥5 letters during follow-up. Patients with lower BCVA at baseline had the lowest final BCVA (p < 0.001) but the highest BCVA gain (p = 0.02). The best overall improvement in mean central macular thickness (CMT) occurred at 18 months (p < 0.0001). The improvement in BCVA was inversely associated with the decrease in CMT and showed a decrease when CMT increased (DME recurrence). According to the history of vitrectomy, we did not find any significant difference in mean final BCVA (p = 0.1) and mean BCVA gain (p = 0.2) between eyes previously vitrectomized or not. A total of 23 eyes (37.1%) required additional treatment for DME, and 17.7% required an IOP-lowering procedure during follow-up. In conclusion, this real-life observational study demonstrated the efficacy and safety of the FAc implant in patients with chronic DME already treated with other available therapies.
‘I don’t understand it’: first in family graduates recognising and mobilising capitals for employment

ABSTRACT Success in a complex labour market requires astute planning, preparation and foresight, particularly within the context of the massification of higher education, increasing graduate competitiveness, and a discourse of employability which places the onus of employment on the individual. A cohort experiencing noticeably weaker graduate employment outcomes are students who are the first in their family to attend university, a group often representing a diversity of backgrounds and intersecting equity categories. Drawing on interviews and surveys of near completing Australian first in family (FiF) students, recent graduates and alumni, this article explores how employability was experienced and enacted by participants. Through the application of Pierre Bourdieu’s work on capital theory, the article contributes valuable insights into the experience of FiF students’ graduate employment seeking, specifically how their existing capitals, including those that are social, cultural and symbolic in nature, interacted with the job market to achieve (or otherwise) desirable graduate employment. Findings from this study point to a number of urgently needed strategies for the FiF cohort to achieve professional goals.
Deep Covariance Alignment for Domain Adaptive Remote Sensing Image Segmentation

Unsupervised domain adaptive (UDA) image segmentation has recently gained increasing attention, aiming to improve the generalization capability for transferring knowledge from the source domain to the target domain. However, in high spatial resolution remote sensing image (RSI), the same category from different domains (e.g., urban and rural) can appear to be totally different with extremely inconsistent distributions, which heavily limits the UDA accuracy. To address this problem, in this article, we propose a novel deep covariance alignment (DCA) model for UDA RSI segmentation. The DCA can explicitly align category features to learn shared domain-invariant discriminative feature representations, which enhance the ability of model generalization. Specifically, a category feature pooling (CFP) module is first used to extract category features by combining coarse outputs and deep features. Then, we leverage a novel covariance regularization (CR) to enforce the intracategory features to be closer and the intercategory features to be further separate. Compared with the existing category alignment methods, our CR aims to regularize the correlation between different dimensions of the features, and thus performs more robustly when dealing with divergent category features of imbalanced and inconsistent distributions. Finally, we propose a stagewise procedure to train the DCA to alleviate error accumulation. Experiments on both rural-to-urban and urban-to-rural scenarios of the LoveDA dataset demonstrate the superiority of our proposed DCA over other state-of-the-art UDA segmentation methods. Code is available at https://github.com/Luffy03/DCA.
RURAL TOURISM FIRMS IN THE COVID-19 ENVIRONMENT: SOUTH AFRICAN CHALLENGES

One consequence of the COVID-19-induced changing consumer travel preferences is growing demand from urban residents for open spaces and the experiences of rural destinations. This re-focuses attention on the challenges of rural tourism firms and of issues of developing rural tourism destinations. In extant international scholarship only limited studies have been undertaken for sub-Saharan Africa. This paper contributes to research debates on rural tourism change in the Global South and more particularly around COVID-19 and the development prospects for rural tourism in South Africa. Using 25 qualitative interviews undertaken in the rural Thaba Chweu Local Municipality of Mpumalanga province it is shown that the challenges facing rural tourism relate to weaknesses in the local institutional environment that have existed for the past two decades. The core constraints on expansion on rural tourism surround issues of the local government mismanagement and corruption. The consequence has been limited provision of basic services and maintenance of critical infrastructure, most especially roads, water and power supplies, which are essential for successful rural tourism development. It is concluded that the leading challenges facing rural tourism firms in South Africa are markedly different from issues which are highlighted in scholarship concerning rural tourism in the Global North.
Oxaliplatin-related Portal Hypertension Complicated with Esophageal Varices and Refractory Massive Ascites

Oxaliplatin, widely used as a chemotherapy drug for colorectal cancer, is known to cause various adverse reactions. In particular, special attention for the development of portal hypertension associated with porto-sinusoidal vascular disease is necessary, as it is a serious adverse life-threating reaction, although rare. We herein report a case of oxaliplatin-related portal hypertension that developed several years after oxaliplatin administration and led to esophageal varices and refractory massive ascites. Clinical physicians should be aware of the possibility of oxaliplatin-induced portal hypertension and its possible development over a long period after discontinuation of the drug.
Neuroprotective Effects of TRPM7 Deletion in Parvalbumin GABAergic vs. Glutamatergic Neurons following Ischemia

Oxidative stress induced by brain ischemia upregulates transient receptor potential melastatin-like-7 (TRPM7) expression and currents, which could contribute to neurotoxicity and cell death. Accordingly, suppression of TRPM7 reduces neuronal death, tissue damage and motor deficits. However, the neuroprotective effects of TRPM7 suppression in different cell types have not been investigated. Here, we found that induction of ischemia resulted in loss of parvalbumin (PV) gamma-aminobutyric acid (GABAergic) neurons more than Ca2+/calmodulin-kinase II (CaMKII) glutamatergic neurons in the mouse cortex. Furthermore, brain ischemia increased TRPM7 expression in PV neurons more than that in CaMKII neurons. We generated two lines of conditional knockout mice of TRPM7 in GABAergic PV neurons (PV-TRPM7−/−) and in glutamatergic neurons (CaMKII-TRPM7−/−). Following exposure to brain ischemia, we found that deleting TRPM7 reduced the infarct volume in both lines of transgenic mice. However, the volume in PV-TRPM7−/− mice was more significantly lower than that in the control group. Neuronal survival of both GABAergic and glutamatergic neurons was increased in PV-TRPM7−/− mice; meanwhile, only glutamatergic neurons were protected in CaMKII-TRPM7−/−. At the behavioral level, only PV-TRPM7−/− mice exhibited significant reductions in neurological and motor deficits. Inflammatory mediators such as GFAP, Iba1 and TNF-α were suppressed in PV-TRPM7−/− more than in CaMKII-TRPM7−/−. Mechanistically, p53 and cleaved caspase-3 were reduced in both groups, but the reduction in PV-TRPM7−/− mice was more than that in CaMKII-TRPM7−/− following ischemia. Upstream from these signaling molecules, the Akt anti-oxidative stress signaling was activated only in PV-TRPM7−/− mice. Therefore, deleting TRPM7 in GABAergic PV neurons might have stronger neuroprotective effects against ischemia pathologies than doing so in glutamatergic neurons.
The Influence of Nurse Education Level on Hospital Readmissions—A Cost-Effectiveness Analysis

Background: Readmissions are adverse, costly, and potentially preventable. The study aimed to evaluate the cost-effectiveness of reducing readmissions resulting from missed care, depending on the level of education of nurses, from the perspective of the service provider. Methods: We calculated missed care resulting in additional readmissions based on the longitudinal study conducted between 2012 and 2014, as well as readmissions that could have been potentially prevented by adding a 10% increase in hours of nursing care provided by BSN/MSc nurses for 2014. The cost-effectiveness analysis (CEA) was performed to calculate the cost-effectiveness of preventing one hospitalization in non-surgical and surgical wards by increasing the number of nursing hours provided by BSN/MSc nurses. Cost–benefit analysis (CBA) was performed, and the CBR (cost–benefit ratio) and BCR (benefit–cost ratio) were calculated. Results: Increasing the number of hours of nursing care (RN) by 10% decreased the chance for an unplanned readmission by 11%; (OR = 0.89; 95% CI: 0.78−1.01; p = 0.08) in non-surgical wards and 43% (OR = 0.57; 95% CI: 0.49−0.67; p < 0.001) in surgical wards. In non-surgical wards, the number of readmissions that were preventable with extra hours provided by BSN/MSc nurses was 52, and the cost-effectiveness ratio (CER) was USD 226.1. The number of preventable readmissions in surgical wards was 172, and the CER was USD 54.96. In non-surgical wards, the CBR was USD 0.07, while the BCR was USD 1.4. In surgical wards, the CBR was USD 0.02, and the BCR was USD 4.4. Conclusions: The results of these studies broaden the understanding of the relationship among nursing education, patient readmission, and the economic outcomes of hospital care. According to the authors, the proposed intervention has an economic justification. Hence, the authors recommend it for approval by the service provider.
INVESTIGATION OF STARTER CULTURE PROPERTIES AND ANTIFUNGAL ACTIVITIES OF PICKLE-DERIVED LACTIC ACID BACTERIA

Investigation of starter culture properties and antifungal activities of pickle-derived lactic ABSTRACT Fermented foods, which are widely consumed around the world, are of great importance for human health. Standard production should be carried out in order to extend the shelf life of fermented products and increase their positive effects on human health. Therefore, there is a need for starter cultures that can be used in the production of fermented products. In this study, antifungal activity on 9 yeast isolates, antibiotic resistance, growth at different temperatures, pH and salt concentrations, arginine hydrolysis and gas production from glucose of 5 lactic acid bacteria ( Lactobacillus brevis, Lactobacillus plantarum, Lactobacillus paracasei, Pediococcus parvulus, Leuconostoc holzapfel ) were investigated. The lactic acid bacteria have antifungal effects on all yeasts except Hanseniaspora opuntiae, Kazachstania exigua and Pichia fermentans , and they grow at 10 and 25 o C, 3.9 and 5 pH and 4% salt concentration. In addition, all of the isolates showed resistance to vancomycin. The results indicated that L. brevis, L. plantarum, L. paracasei strains can be used as starter cultures in term of standart pickle production and antifungal effect.
Pilot Testing in the Wild: Feasibility, Acceptability, Usage Patterns, and Efficacy of an Integrated Web and Smartphone Platform for Bipolar II Disorder

Background Bipolar II disorder (BD-II) is associated with significant burden, disability, and mortality; however, there continues to be a dearth of evidence-based psychological interventions for this condition. Technology-mediated interventions incorporating self-management have untapped potential to help meet this need as an adjunct to usual clinical care. Objective The objective of this pilot study is to assess the feasibility, acceptability, and clinical utility of a novel intervention for BD-II (Tailored Recovery-oriented Intervention for Bipolar II Experiences; TRIBE), in which mindfulness-based psychological content is delivered via an integrated web and smartphone platform. The focus of the study is evaluation of the dynamic use patterns emerging from ecological momentary assessment and intervention to assist the real-world application of mindfulness skills learned from web-delivered modules. Methods An open trial design using pretest and posttest assessments with nested qualitative evaluation was used. Individuals (aged 18-65 years) with a diagnosis of BD-II were recruited worldwide and invited to use a prototype of the TRIBE intervention over a 3-week period. Data were collected via web-based questionnaires and phone interviews at baseline and 3-week follow-up. Results A total of 25 participants completed baseline and follow-up assessments. Adherence rates (daily app use) were 65.6% across the 3-week study, with up to 88% (22/25) of participants using the app synergistically alongside the web-based program. Despite technical challenges with the prototype intervention (from user, hardware, and software standpoints), acceptability was adequate, and most participants rated the intervention positively in terms of concept (companion app with website: 19/25, 76%), content (19/25, 76%), and credibility and utility in supporting their management of bipolar disorder (17/25, 68%). Evaluation using behavioral archetypes identified important use pathways and a provisional model to inform platform refinement. As hypothesized, depression scores significantly decreased after the intervention (Montgomery-Asberg Depression Rating Scale baseline mean 8.60, SD 6.86, vs follow-up mean 6.16, SD 5.11; t24=2.63; P=.01; Cohen d=0.53, 95% CI 0.52-4.36). Conclusions Our findings suggest that TRIBE is feasible and represents an appropriate and acceptable self-management program for patients with BD-II. Preliminary efficacy results are promising and support full development of TRIBE informed by the present behavioral archetype analysis. Modifications suggested by the pilot study include increasing the duration of the intervention and increasing technical support.
Long COVID and neuropsychiatric manifestations (Review)

There is accumulating evidence in the literature indicating that a number of patients with coronavirus disease 2019 (COVID-19) may experience a range of neuropsychiatric symptoms, persisting or even presenting following the resolution of acute COVID-19. Among the neuropsychiatric manifestations more frequently associated with ‘long COVID’ are depression, anxiety, post-traumatic stress disorder, sleep disturbances, fatigue and cognitive deficits, that can potentially be debilitating and negatively affect patients' wellbeing, albeit in the majority of cases symptoms tend to improve over time. Despite variations in results obtained from studies using different methodological approaches to define ‘long COVID’ syndrome, the most widely accepted factors associated with a higher risk of developing neuropsychiatric manifestations include the severity of foregoing COVID-19, the female sex, the presence of comorbidities, a history of mental health disease and an elevation in the levels of inflammatory markers, albeit further research is required to establish causal associations. To date, the pathophysiological mechanisms implicated in neuropsychiatric manifestations of ‘long COVID’ remain only partially elucidated, while the role of the indirect effects of the COVID-19 pandemic, such as social isolation and uncertainty concerning social, financial and health recovery post-COVID, have also been highlighted. Given the alarming effects of ‘long-COVID’, interdisciplinary cooperation for the early identification of patients who are at a high risk of persistent neuropsychiatric presentations, beyond COVID-19 recovery, is crucial to ensure that appropriate integrated physical and mental health support is provided, with the aim of mitigating the risks of long-term disability at a societal and individual level.
Food Insecurity across the Life-Course and Cognitive Function among Older Mexican Adults

Background: Food insecurity remains a global public health problem. Experiencing food insecurity is related to poorer cognitive function among older adults. However, few studies have examined how food insecurity, experienced over the life-course, relates to cognitive function among older adults in Mexico. Methods: Data came from the 2015 Mexican Health and Aging Study (n = 11,507 adults aged 50 and over). Early- and late-life food insecurity were ascertained by self-report. We evaluated how both measures of food insecurity related to the performance of multiple cognitive tasks (Verbal Learning, Verbal Recall, Visual Scanning, and Verbal Fluency), while controlling for key health and sociodemographic confounders using linear regression. Results: In descriptive analyses, respondents who experienced food insecurity in either early or late life performed significantly worse on all cognitive tasks when compared to the food secure. In models adjusted for health and sociodemographic confounders, early-life food insecurity predicted worse Verbal Learning performance and late-life food insecurity was associated with poorer Visual Scanning performance. Conclusions: Food insecurity was related to poorer cognitive function in a nationally representative sample of older adults in Mexico. However, results suggested that the significance of effects depended on cognitive task and when in the life-course food insecurity was experienced.