Miracle-dz/UniFAR-FTUs huggingface dataset:
PREVALENCE AND CHARACTERISATION OF EXTENDED-SPECTRUM BETA-LACTAMASES AND PLASMID-MEDIATED QUINOLONES RESISTANCE IN Enterobacteriaceae ISOLATED FROM COMPANION ANIMALS

Antimicrobial resistance is a major public health concern worldwide. This study aims to determine the prevalence of Enterobacterales producing beta-lactamase (TEM, SHV, OXA) or extended-spectrum beta-lactamases (ESBL), as well as plasmid-mediated resistance to quinolones (PMQR) (qnrA, qnrB, qnrS) in companion animals from the northeast region of Romania. A total of 124 faecal samples were collected aseptically from healthy dogs attending the veterinary practice for vaccination and cultivated on Brilliance ESBL medium (Oxoid, UK). The ESBL production testing was performed using the combination disc test. The identification of Enterobacterales strains was achieved using molecular identification and based on biochemical tests. Antimicrobial susceptibility testing was performed using the disk diffusion method. Identification of genes encoding for beta-lactamase enzymes and genes encoding plasmid-mediated resistance to quinolones was performed by PCR according to the protocols previously described. After ESBL screening, 31 (31/124; 25%) extended-spectrum cephalosporin (ESC)-resistant Enterobacterales were obtained, and 67.74% (21/31) of them were confirmed as ESBL-producers. Regarding the Enterobacterales species, 27 (27/31; 87.1%) were Escherichia coli and 4 (4/31; 12.9%) strains were Klebsiella pneumoniae. Among the ESBL-producing isolates, the blaCTX-M-1 gene group was predominant (58.82%), followed by the blaCTX-M-9 group (41.18%). The blaTEM, blaSHV and blaOXA gene groups were identified in 54.83%, 29.03% and 3.22% of the analysed strains, respectively. The prevalence of PMQR genes was 22.58% and consisted only of qnrS (19.35%) and qnrA (3.22%) genes. The prevalence of ESBL strains related to the total number of analysed samples was 16.93% (21/124). The findings show a significant prevalence of ESBLs and PMQR genes in Enterobacterales strains isolated from the faeces of healthy dogs, implying that pets may pose a risk of transmitting ESBL strains to other animals or owners.
1500-year cycle dominated Holocene dynamics of the Yellow River delta, China

The world’s mega-deltas are extremely important from a human perspective and attract considerable effort to reveal their evolution, growth-related driving forces, and human impacts. Here, we report a case study on the Holocene deltaic evolution of the Yellow River, through development of a conceptual model, which is compared with paleo-proxy to analyze the forcing acting on the delta. The main conclusion is that superlobe switching was modulated by the 1500-year cycle. Cooling in Mongolia in response to strong Bond IRD events, which is coincident with warming in eastern China due to a strong Kuroshio Current, enhances the meridional temperature gradient, which then increases cyclone frequency and activates dust storms and terrestrial erosion throughout the catchment. Enhanced erosion supplies great amounts of material to the Yellow River and causes channel evulsion and superlobe development, expressed as dominant 1500-year cycle. At the same time, summer monsoon and solar forcing are uncorrected with deltaic evolution on these timescales. Therefore, we conclude that Holocene dynamics of the delta on a millennial timescale was dominated by winter cyclone activity across northern China and Mongolia.
Mapping the terrain: a scoping review of empirical studies on the big five personality traits and QoL in China

The relationship between personality traits and Quality of Life (QoL) has garnered increasing scholarly attention, particularly within the context of China. This scoping review synthesizes existing literature on the connection between the Big Five personality traits (Openness, Conscientiousness, Extraversion, Agreeableness, and Neuroticism) and QoL among the Chinese population. The review explores correlations, measurement instruments, and theoretical frameworks employed in these studies. The study’s significance lies in the profound implications for healthcare policies, organizational behavior, and social welfare programs in China, where rapid social and economic changes impact well-being. Investigating personality traits’ impact on QoL can inform tailored interventions benefiting diverse Chinese subpopulations. This review addresses three primary research questions: (1) How do the Big Five personality traits correlate with QoL in different Chinese subpopulations, and what are the mediating or moderating factors? (2) What instruments assess these traits and QoL in the Chinese cultural context, and how are they validated? (3) What theoretical or disciplinary frameworks guide this research in China? Following a systematic PRISMA-ScR framework and a customized “C-BFQLC” protocol, the study identified 170 relevant documents. After rigorous screening, ten studies met the inclusion criteria, constituting 5.03% of the initial records. This scoping review critically examines the interplay between the Big Five personality traits and QoL in China, a context marked by rapid socioeconomic changes and cultural diversity. Employing a systematic approach guided by the PRISMA-ScR framework and our unique ‘C-BFQLC’ protocol, we meticulously analyzed 170 documents, selecting nine that met our rigorous inclusion criteria. Despite the emerging nature of this research area in the Chinese context, our study reveals significant insights into how individual personality traits influence various dimensions of well-being. The implications of these findings are profound, extending beyond academic discourse to inform healthcare policies, organizational behavior, and social welfare programs in China. Our review not only offers a comprehensive synthesis of the current research landscape but also identifies critical gaps in the literature. It emphasizes the urgent need for further culturally nuanced research to understand the complex dynamics of personality traits and QoL in China. This work lays a foundational framework for future investigations and the development of tailored interventions aimed at enhancing the well-being of diverse Chinese populations, including the elderly, people with disabilities, and specific occupational groups.
Improvement of Understanding of Vapor-dominated Geothermal Resources

Vapor-dominated geothermal resources were first exploited for commercial power generation, because of the easiness for utilization, i.e. wells in vapor-dominated geothermal fields produce dry steam alone. Understanding of the resource was improved first by accumulation of field experience, examples and data. Then, several different conceptual models were developed based on interpretations of the data. These conceptual models were tested and validated by numerical modeling, and then evolved into the current form. These processes led to the current understanding of the vapor-dominated geothermal resources. Thus, the key factors which contributed for the improvement are the increase of field data and experiences both in quantity and quality, and the advancement of numerical techniques. Among many vapor-dominated geothermal fields, real natural state of a reservoir has only been confirmed at Matsukawa, to date.
Exendin-4 affects calcium signalling predominantly during activation and activity of beta cell networks in acute mouse pancreas tissue slices

Tight control of beta cell stimulus-secretion coupling is crucial for maintaining homeostasis of energy-rich nutrients. While glucose serves as a primary regulator of this process, incretins augment beta cell function, partly by enhancing cytosolic [Ca2+] dynamics. However, the details of how precisely they affect beta cell recruitment during activation, their active time, and functional connectivity during plateau activity, and how they influence beta cell deactivation remain to be described. Performing functional multicellular Ca2+ imaging in acute mouse pancreas tissue slices enabled us to systematically assess the effects of the GLP-1 receptor agonist exendin-4 (Ex-4) simultaneously in many coupled beta cells with high resolution. In otherwise substimulatory glucose, Ex-4 was able to recruit approximately a quarter of beta cells into an active state. Costimulation with Ex-4 and stimulatory glucose shortened the activation delays and accelerated beta cell activation dynamics. More specifically, active time increased faster, and the time required to reach half-maximal activation was effectively halved in the presence of Ex-4. Moreover, the active time and regularity of [Ca2+]IC oscillations increased, especially during the first part of beta cell response. In contrast, subsequent addition of Ex-4 to already active cells did not significantly enhance beta cell activity. Network analyses further confirmed increased connectivity during activation and activity in the presence of Ex-4, with hub cell roles remaining rather stable in both control experiments and experiments with Ex-4. Interestingly, Ex-4 demonstrated a biphasic effect on deactivation, slightly prolonging beta cell activity at physiological concentrations and shortening deactivation delays at supraphysiological concentrations. In sum, costimulation by Ex-4 and glucose increases [Ca2+]IC during beta cell activation and activity, indicating that the effect of incretins may, to an important extent, be explained by enhanced [Ca2+]IC signals. During deactivation, previous incretin stimulation does not critically prolong cellular activity, which corroborates their low risk of hypoglycemia.
Macrophage‐derived HMGB1 is dispensable for tissue fibrogenesis

Alarmins and damage‐associated molecular patterns (DAMPs) are powerful inflammatory mediators, capable of initiating and maintaining sterile inflammation during acute or chronic tissue injury. Recent evidence suggests that alarmins/DAMPs may also trigger tissue regeneration and repair, suggesting a potential contribution to tissue fibrogenesis. High mobility group B1 (HMGB1), a bona fide alarmin/DAMP, may be released passively by necrotic cells or actively secreted by innate immune cells. Macrophages can release large amounts of HMGB1 and play a key role in wound healing and regeneration processes. Here, we hypothesized that macrophages may be a key source of HMGB1 and thereby contribute to wound healing and fibrogenesis. Surprisingly, cell‐specific deletion approaches, demonstrated that macrophage‐derived HMGB1 is not involved in tissue fibrogenesis in multiple organs with different underlying pathologies. Compared to control HMGB1Flox mice, mice with macrophage‐specific HMGB1 deletion (HMGB1ΔMac) do not display any modification of fibrogenesis in the liver after CCL4 or thioacetamide treatment and bile duct ligation; in the kidney following unilateral ureter obstruction; and in the heart after transverse aortic constriction. Of note, even under thermoneutral housing, known to exacerbate inflammation and fibrosis features, HMGB1ΔMac mice do not show impairment of fibrogenesis. In conclusion, our study clearly establishes that macrophage‐derived HMGB1 does not contribute to tissue repair and fibrogenesis.
The correlation between provision time of weaning food and history of exclusive breastfeeding with nutritional status in toddlers

<p><strong><em>Background: </em></strong><em>The toddler period is a golden age for the formation and development of children starting from the basic sensory abilities, thinking, speaking, and intensive intellectual mental growth and early moral growth. So that the nutritional status of children under five is very, very important to study because it is related to the current increasing stunting status. Cases of stunting under five currently have the highest number when compared to other forms of malnutrition. The prevalence of stunting in DIY in 2018 was 12.37% and this figure fell to 10.69% in 2019 but in 2020 it rose to 11.08%. </em><strong><em> </em></strong><em>The highest prevalence of stunting is Gunung Kidul Regency (17.43) and the lowest is Sleman Regency (7.24). From this figure, it can be seen that the prevalence of very short toddlers in DIY is lower when compared to Riskesdas in 2018 (21.4%) </em>(1)<em>. </em><strong><em> </em></strong></p><p><strong><em>Objectives: </em></strong><em>To determine the relationship between the characteristics (education, occupation) of the mother, provision time of weaning food, exclusive breastfeeding, and the provision of deworming drugs with nutritional status in toddlers aged 6-60 months in 2 areas, namely in the work area of the Pajangan Health Center and the Work Area of the Public Health Center, Sedayu</em><strong><em>. </em></strong></p><p><strong><em>Methods: </em></strong><em>Analytic survey with cross-sectional design. Analysis of the data using the chi-square test with a sample of 35 mothers who have children under five. </em><strong><em> </em></strong></p><p><strong><em>Results: </em></strong><em>The results showed that there was a correlation between the time of weaning food (p = 0.0001), history of exclusive breastfeeding (p = 0.0001), and the nutritional status of children under five. However, there was no correlation between education (p = 0.657), occupation (p = 0.579), deworming (p = 0.410)</em><strong><em>. </em></strong></p><strong><em>Conclusions: </em></strong><em>There is a correlation between the time of weaning food, history of exclusive breastfeeding nutritional status in toddlers</em>
Do moderate-to-late preterm twins and singletons differ in the early motor repertoire and later developmental functioning?

Purpose: The aim of this study was to investigate the differences in early motor repertoire and later developmental functioning between moderate-to-late preterm twins and singletons. Material and Methods: The study included 40 moderate-to-late preterm twin infants (50% female), and 40 moderate-to-late preterm singleton infants (50% female). All infants were assessed from 9 up to 20 post-term weeks of corrected age using the General Movement Assessment (GMA), and between 24 and 42 months of age using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). Results: There were no differences between the Motor Optimality Score (MOS) and its subcategories, including fidgety movements, obtained as a result of detailed GMA (p>0.05), when the early motor repertoire results were examined. At later ages, there were also no significant differences in cognitive, language, and motor domain composite scores between twin and singleton infants, according to Bayley-III (p>0.05). Discussion: Our results suggest moderate-to-late preterm twin infants had a similar developmental process to moderate-to-late preterm singleton infants from early periods up to 3.5 years of age. However, all preterm infants, including moderate-to-late infants, should be assessed in the clinic in terms of the risks of developmental problems from the early period of life.
Estimation of Pattern of Skull Fractures in Homicidal Deaths: An Autopsy Based Cross Sectional Study Conducted in a Tertiary Care Hospital

The head is the most vital part of the body among various organs as the injury to the head will result in fataloutcomes compared to injuries sustained to other parts of the body. There has been an increased global incidence of head injuries in case of homicidal deaths. The present study aims to estimate the various patterns of the skull fractures in case of homicidal deaths and also the nature of injury causing such skull fractures in homicidal deaths.The present cross-sectional study revealed that out of 4036 autopsies, there were 74 cases of homicidal deaths with 67 male and 7 female cases. The skull fracture was noticed in 54 cases out of these 74 cases. The maximum number of homicidal deaths were found to be in the age group of 21 to 40 years. Among the different types of skull fractures, the isolated cut fracture contributed to 46.30% of cases followed by isolated fissured fractures and then by the combination of other types of skull fractures. The nature of injury causing skull fractures was blunt force in 51.8% of the cases then by sharp force injuries and then by the combination of these two. To bring down the incidence of homicidal deaths among the younger individuals, strict enforcements of law may be ensued on possession of blunt and sharp force weapons which are used for the brutal attacks.
Cruise Tourism in Japanese Coastal Cities: The Role of Revisit and Word-of-Mouth Intentions as Proxies for Behavior

This two-wave study was conducted within Japan’s cruise tourism landscape to augment existing research and delve into an understudied area by evaluating the role of destination revisit and word-of-mouth (WOM) intentions as surrogates for self-reported behaviors in inbound tourism. The study employs partial least squares structural equation modeling to analyze data collected in 2018 and 2022, exploring the relationships among overall satisfaction, repeat visitation rate, distance, and revisit and WOM intentions. The analysis of the estimation partition, consisting of 580 valid first-wave responses, helps isolate the critical factors associated with overall satisfaction, such as destination attractiveness, transportation, prices, and tourist attractions and facilities. Based on 77 valid responses gathered in the second wave, which as a sample size has been deemed sufficient for a post-hoc power analysis, the findings significantly reveal that cruise goers’ intentions correlate with self-reported behaviors for revisits and WOM, with intentions explaining 14.4% and 9.3% of the variance observed in the respective behaviors. These results emphasize intentions’ multifaceted role in predicting tourist behavior, underscoring the importance of context-specific constructs in tourism management and unveiling potential pathways for further exploration. The conclusion offers insights that may guide future research and industry practices in crafting strategies to enhance visitor satisfaction and loyalty.
Comparison of distance-based spatial weight matrix in modeling Internet signal strengths in Tasikmalaya regency using logistic spatial autoregressive model

To ensure that national development objectives in rural areas are achieved evenly and sustainably, the Government of Indonesia applies the principles of Village Sustainable Development Goals (SDGs), which are derivative programs of SDGs. One of the indicators in measuring the progress and independence of villages in Indonesia is the availability of cellular phone signal access. Cellular phone signals have a vital role because most internet users in Indonesia rely on mobile data connections from cellular operators. However, the signal emitted by a provider tower has a limited range. According to the data of the Developing Villages Index in 2022, Tasikmalaya Regency is one of the regencies with the highest number of villages that have weak signal strength in West Java Province, Indonesia. To examine the effect of distance and height difference between the placement of the nearest provider tower and the location of the Village Office on the internet signal strength category in Tasikmalaya Regency, Logistic Spatial Autoregressive modeling is needed. In this study, the Bayesian Markov-Chain Monte Carlo estimation method was used, because it has advantages in flexibility and computational efficiency. In spatial modeling, there is a spatial weight matrix determined by the researcher’s understanding of the observed phenomenon. The variable observed in this study is signal strength, which has an orientation at a distance. However, there are several types of distance-based spatial weight matrices, such as K-nearest neighbor, radial distance, power distance, and exponential distance. To determine the most suitable distance-based spatial weight matrix in internet signal strength modeling, the four (4) weight matrices were compared based on the goodness of fit measure models, calculated from the confusion matrix. The results of the analysis showed that the radial distance weight matrix with a threshold distance of d = 1.7km is the most suitable use of distance-based spatial weight matrix in internet signal modeling in Tasikmalaya Regency. The weight matrix exerted a positive spatial autocorrelation effect of 57.141%. In addition, the height difference factor between the location of the provider tower with the location of the village office has a greater effect than the horizontal distance.
Associations between post-acute sequelae of SARS-CoV-2, COVID-19 vaccination and HIV infection: a United States cohort study

Background People with HIV (PWH) are at higher risk of complications from acute COVID-19, but their risk of subsequent post-acute sequelae of SARS-CoV2 (PASC) remains unclear. Although vaccination is protective of PASC among survivors in the general population, its effectiveness in PWH has not been explored. Methods We used the TriNetX health research database to identify patients with and without HIV aged ≥18 years with confirmed SARS-CoV-2 between January 1, 2020 and July 20, 2023. We employed 1:1 propensity score matching to balance HIV and non-HIV cohorts based on demographics and key comorbidities. The primary outcomes accessed odds of PASC and mortality and secondary outcomes assessed odds of PASC and mortality by vaccination status. PASC was defined as new-onset conditions ≥ 28 days after COVID-19 diagnosis. We reported odd ratios (OR) of outcomes with 95% confidence intervals (CI), with statistical significance set at p < 0.05. Results Of 3,029,340 people with confirmed SARS-CoV-2 infection, 0.5% (n=13,214) were PWH, with 7.5% of PWH (n=989) vaccinated. After 28 days post-COVID-19, PWH had higher odds of mortality compared with their non-HIV counterparts (OR 1.22, 95% CI 1.06-1.40) and developing new-onset HTN (OR 1.18, 95% CI 1.03-1.36), heart disease (OR 1.35 95% CI 1.18-1.54), malignancy (OR 1.49, 95% CI 1.22-1.81), and mental disorders (OR 1.62, 95% CI 1.42-1.85). Furthermore, vaccinated PWH had significantly lower odds of death (OR 0.63, 95% CI 0.42-0.93) and new-onset PASC outcomes: DM (OR 0.65, 95% CI 0.43-0.99), heart disease (OR 0.58, 95% CI 0.4-0.85), mental disorders (OR 0.66, 95% CI 0.43-1.00), fatigue (OR 0.82, 95% CI 0.67-0.98), respiratory (OR 0.82, 95% CI 0.70-0.95) and gastrointestinal symptoms (OR 0.78, 95% CI 0.67-0.90). Conclusion HIV-positive status increased PASC odds, while COVID-19 vaccination reduced PASC and all-cause mortality risks in PWH.
The Impact of Academic Supervision and Professional Competence on the Performance of Teachers of Private Islamic Junior High School Teachers In West Jakarta

This study aims to determine the effect of academic supervision and professional competence on teacher performance in Private Islamic Junior High Schools in West Jakarta. This research uses a quantitative approach with survey methods and path analysis techniques. The population of this study was 223 teachers working in private Islamic junior high schools in Kalideres and Cengkareng sub-districts, with a sample of 69 teachers selected with the Slovin formula. The data collection technique used is a questionnaire distributed through Google Forms. The results showed that academic supervision and professional competence directly affect teacher performance. Academic supervision also directly affects the professional competence of teachers. This research advises principals and teachers to improve performance through academic supervision activities and professional competency development.