Miracle-dz/UniFAR-FTUs huggingface dataset:
Warmer water temperature and epizootic shell disease reduces diversity but increases cultivability of bacteria on the shells of American Lobster (Homarus americanus)

The American lobster, Homarus americanus, is an economically valuable and ecologically important crustacean along the North Atlantic coast of North America. Populations in southern locations have declined in recent decades due to increasing ocean temperatures and disease, and these circumstances are progressing northward. We monitored 57 adult female lobsters, healthy and shell-diseased, under three seasonal temperature cycles for a year, to track shell bacterial communities using culturing and 16S rRNA gene sequencing, progression of ESD using visual assessment, and antimicrobial activity of hemolymph. The richness of bacterial taxa present, evenness of abundance, and community similarity between lobsters was affected by water temperature at the time of sampling, water temperature over time based on seasonal temperature regimes, shell disease severity, and molt stage. Several bacteria were prevalent on healthy lobster shells but missing or less abundant on diseased shells, although putative pathogens were found on all shells regardless of health status. Graphical abstract
Enhancing the three-dimensional electronic structure in 1111-type iron arsenide superconductors by H substitution

The 1111-type iron arsenide hydride CaFe1-xCoxAsH was synthesized by high-pressure solid-state reaction, and its electronic structure and superconducting properties were investigated. Bulk superconductivity was observed at x = 0.07-0.26. A maximum superconducting critical temperature Tcmax of 23 K was observed at x = 0.07. These values are in agreement with those of CaFe1-xCoxAsF. The calculated Fermi surface of CaFeAsH has a small three-dimensional 3D hole pocket around the Gamma point. This is a result of weak covalent bonding between the As 4p and H 1s orbitals. No such covalency exists in CaFeAsF, because the energy level of the F 2p orbital is sufficiently deep to inhibit overlap with the As 4p orbital. The similar superconducting properties of CaFe1-xCoxAsH and CaFe1-xCoxAsF are explained on the nesting scenario. The small 3D hole pocket of CaFe1-xCoxAsH does not significantly contribute to electron excitation. These findings encourage exploration of hydrogen-containing 1111-type iron-based materials with lower anisotropies and higher Tc applicable to superconducting wires and tapes.
Evidence for survival of Pleistocene climatic changes in Northern Evidence for survival of Pleistocene climatic changes in Northern refugia by the land snail Trochoidea geyeri refugia by the land snail Trochoidea geyeri

Background: The study of organisms with restricted dispersal abilities and presence in the fossil record is particularly adequate to understand the impact of climate changes on the distribution and genetic structure of species. Trochoidea geyeri (Soós 1926) is a land snail restricted to a patchy, insular distribution in Germany and France. Fossil evidence suggests that current populations of T. geyeri are relicts of a much more widespread distribution during more favourable climatic periods in the Pleistocene. Results: Phylogeographic analysis of the mitochondrial 16S rDNA and nuclear ITS-1 sequence variation was used to infer the history of the remnant populations of T. geyeri . Nested clade analysis for both loci suggested that the origin of the species is in the Provence from where it expanded its range first to Southwest France and subsequently from there to Germany. Estimated divergence times predating the last glacial maximum between 25–17 ka implied that the colonization of the northern part of the current species range occurred during the Pleistocene. Conclusion: We conclude that T. geyeri could quite successfully persist in cryptic refugia
Narrow band endoscopic diagnosis of portal hypertensive gastropathy in cirrhotic patients

ABSTRACT Background Portal hypertensive gastropathy (PHG) is an overlooked complication of liver cirrhosis, as it is a source of acute upper gastrointestinal bleeding and cause of chronic blood loss. Objective To assess the role of narrow band endoscopy in the diagnosis of PHG in cirrhotic patients. Methods Fifty patients with liver cirrhosis were examined by both conventional White Light Endoscopy (WLE) and Narrow Band Technology Variable Intelligent Staining Technology (VIST) using Sonoscape endoscope HD500. Biopsies were taken from the body of gastric mucosa during endoscopy. Results The prevalence of PHG among patients with liver cirrhosis is around 94% by WLE, 92% by VIST, and 55.3% by pathology. There is no statistical significance between VIST and WLE in case of PHG p = 0,750. The risk of developing oesophageal varices grade 3 in severe PHG is higher than in no or mild PHG (OR = 6.8571, 95% CI 1.6270 to 28.9001, p = 0.0087). Conclusion VIST is comparable and complementary to WLE in diagnosis of PHG. There is poor correlation between pathology and WLE in diagnosis of PHG.
A note on Picard curves of CM-type

We extend the list of Picard curves of CM-type given by Koike and Weng. In particular, our list includes defining equations for the complete list of Picard curves of CM-type defined over $\mathbb{Q}$ up to isomorphism. To this end, we improve their algorithm in some aspects: one needs to precise a root of unity in an accurate application of a Thomae-like formula well-suited for the Picard case, and also use an optimized strategy to evaluate the Riemann theta-series involved.
New prospects for observing and cataloguing exoplanets in well-detached binaries

This paper is devoted to study the circumstances favourable to detect circumstellar and circumbinary planets in well detached binary-star-systems using eclipse timing variations (ETVs). We investigated the dynamics of well detached binary star systems with a star separation from 0.5 to 3~AU, to determine the probability of the detection of such variations with ground based telescopes and space telescopes (like former missions CoRoT and Kepler and future space missions Plato, Tess and Cheops). For the chosen star separations both dynamical configurations (circumstellar and circumbinary) may be observable. We performed numerical simulations by using the full three-body problem as dynamical model. The dynamical stability and the ETVs are investigated by computing ETV maps for different masses of the secondary star and the exoplanet (Earth, Neptune and Jupiter size). In addition we changed the planet's and binary's eccentricities. We conclude that many amplitudes of ETVs are large enough to detect exoplanets in binary star systems. As an application, we prepared statistics of the catalogue of exoplanets in binary star systems which we introduce in this article and compared the statistics with our parameter-space which we used for our calculations. In addition to these statistics of the catalogue we enlarged them by the investigation of well detached binary star systems from several catalogues and discussed the possibility of further candidates.
Are Some Comparative Nutrition Claims Misleading? The Role of Are Some Comparative Nutrition Claims Misleading? The Role of Nutrition Knowledge, Ad Claim Type and Disclosure Conditions Nutrition Knowledge, Ad Claim Type and Disclosure Conditions

As the regulator of all national food advertising, the Federal Trade Commission (FTC) has expressed concern that consumers may be misled by certain comparative nutrient content claims in advertising. To help examine this issue, primary food shoppers were recruited and interviewed in three U.S. markets according to generally accepted procedures for advertising copy tests. The study employs a 2 (ad claim type) x 2 (nutrition knowledge) x 4 (disclosure type) between-subjects design using manipulated print advertisements. Misleading
Effects of reducing scaffolding in an undergraduate electronics lab

Design and scientific investigation are recognized as key components of undergraduate physics laboratory curricula. In light of this, many successful lab programs have been developed to train students to develop these abilities, and students in these programs have been shown to exhibit a higher transfer rate of scientific abilities to new situations. This paper describes data from students in an electronics class for physics majors, in which steps were removed from traditional “cookbook” lab guides in order to give students the opportunity to design circuits. Post-lab quizzes were given to investigate how this later affected the students' ability to determine the function of circuits they hadn't seen before. Results are compared with post-lab quiz results from students who were given complete explicit procedures, and no statistically significant difference between the two groups is found. Possible explanations for the null effect and recommended future research directions are provided.
Particle response during the yielding transition of colloidal glasses

Yielding is central to the relaxation, flow and fracture of a wide range of soft and molecular glasses, but its microscopic origin remains unclear. Here, we elucidate the yielding of a colloidal glass, silica particles 50nm in diameter, by using x-ray scattering (at DESY facility, Hamburg) to monitor the structure factor during the yielding process. We apply a recently introduced combination of vertical small-angle x-ray scattering and rheology [1] to the oscillatory shear measurements (see figure 1 left), and follow the structure factor evolution during the increasing strain amplitude. Surprisingly, we observe a sharp transition at critical strain in the orientational ordering of the nearest-neighbour structure upon yielding, in contrast to the smooth variation of the viscoelastic moduli (see figure 1 right). This transition is accompanied by a sudden change of intensity fluctuations towards Gaussian distributions. Interestingly the crossing point of the viscoelastic moduli occurs close to , allowing us to associate the sharp structural transition with the rheological yielding of the material. Even during the reverse transition, i.e. from large to small strain amplitude the structural transition at happens close to the intersection of the moduli, with almost no hysteresis. We thus identify yielding as a new, dynamically induced transition of the glass in response to the applied shear [2].
Thermal infrared observations of asteroid (99942) Apophis with Herschel

The near-Earth asteroid (99942) Apophis is a potentially hazardous asteroid. We obtained far-infrared observations of this asteroid with the Herschel Space Observatory PACS instrument at 70, 100, and 160 mum. These were taken at two epochs in January and March 2013 during a close-Earth encounter. These first thermal measurements of Apophis were taken at similar phase angles before and after opposition. We performed a detailed thermophysical model analysis by using the spin and shape model recently derived from applying a two-period Fourier series method to a large sample of well-calibrated photometric observations. We found that the tumbling asteroid Apophis has an elongated shape with a mean diameter of 375+14-10 m (of an equal volume sphere) and a geometric V-band albedo of 0.30+0.05-0.06. We found a thermal inertia in the range 250-800 Jm-2 s-0.5 K-1 (best solution at Gamma = 600 Jm-2 s-0.5 K-1), which can be explained by a mixture of low-conductivity fine regolith with larger rocks and boulders of high thermal inertia on the surface. The thermal inertia, and other similarities with (25143) Itokawa indicate that Apophis might also have a rubble-pile structure. If we combine the new size value with the assumption of an Itokawa-like density and porosity we estimate a mass between 4.4 and 6.2 × 1010 kg, which is more than 2-3 times larger than previous estimates. We expect that the newly derived properties will influence impact scenario studies and the long-term orbit predictions of Apophis.
A volumetric framework for quantum computer benchmarks

We propose a very large family of benchmarks for probing the performance of quantum computers. We call them volumetric benchmarks (VBs) because they generalize IBM's benchmark for measuring quantum volume \cite{Cross18}. The quantum volume benchmark defines a family of square circuits whose depth d and width w are the same. A volumetric benchmark defines a family of rectangular quantum circuits, for which d and w are uncoupled to allow the study of time/space performance trade-offs. Each VB defines a mapping from circuit shapes — (w,d) pairs — to test suites C(w,d). A test suite is an ensemble of test circuits that share a common structure. The test suite C for a given circuit shape may be a single circuit C, a specific list of circuits {C1…CN} that must all be run, or a large set of possible circuits equipped with a distribution Pr(C). The circuits in a given VB share a structure, which is limited only by designers' creativity. We list some known benchmarks, and other circuit families, that fit into the VB framework: several families of random circuits, periodic circuits, and algorithm-inspired circuits. The last ingredient defining a benchmark is a success criterion that defines when a processor is judged to have ``passed'' a given test circuit. We discuss several options. Benchmark data can be analyzed in many ways to extract many properties, but we propose a simple, universal graphical summary of results that illustrates the Pareto frontier of the d vs w trade-off for the processor being benchmarked.
BIROn - Birkbeck Institutional Research Online Vestibular modulation of spatial perception.

of vestibular on visuo-spatial processing in neurological described, normal contribution of vestibular inputs to spatial unclear. we used a line bisection task to investigate the effects of galvanic vestibular stimulation (GVS) on spatial perception, and on the transition between near and far space. Brief left-anodal and right-cathodal GVS or right-anodal and left-cathodal GVS were delivered. A sham stimulation condition was also included. Participants bisected lines of different lengths at six distances from the body using a laser pointer. Consistent with previous results, our data showed an overall shift in the bisection bias from left to right as viewing distance increased. This pattern suggests leftward bias in near space, and rightward bias in far space. GVS induced strong polarity dependent effects in spatial perception, broadly consistent with those previously reported in patients: left-anodal and right-cathodal GVS induced a leftward bisection bias, while right-anodal and left-cathodal GVS reversed this effect, and produced bisection bias toward the right side of the space. Interestingly, the effects of GVS were comparable in near and far space. We speculate that vestibular-induced biases in space perception may optimize gathering of information from different parts of the environment.
Spectroscopic characterization of X-ray emitting young stars associated with the Sh 2-296 nebula

We studied a sample of stars associated with the Sh 2-296 nebula, part of the reflection nebulae complex in the region of Canis Major (CMa R1). Our sample corresponds to optical counterparts of X-ray sources detected from observations with the XMM-Newton satellite, which revealed dozens of possible low-mass young stars not yet known in this region. A sample of 58 young star candidates were selected based on optical spectral features, mainly H{\alpha} and lithium lines, observed with multi-objects spectroscopy performed by the Gemini South telescope. Among the candidates, we find 41 confirmed T Tauri and 15 very likely young stars. Based on the H{\alpha} emission, the T Tauri stars were distinguished between classical (17%) and weak-lined (83%), but no significant difference was found in the age and mass distribution of these two classes. The characterization of the sample was complemented by near- and mid-infrared data, providing an estimate of ages and masses from the comparison with pre-main-sequence evolutionary models. While half of the young stars have an age of 1-2 Myrs or less, only a small fraction (~25%) shows evidence of IR excess revealing the presence of circumstellar discs. This low fraction is quite rare compared to most young star-forming regions, suggesting that some external factor has accelerated the disc dissipation.
Development and validation of a novel hypoxia-related signature for prognostic and immunogenic evaluation in head and neck squamous cell carcinoma

Hypoxia plays a critical role in head and neck squamous cell carcinoma (HNSCC) prognosis. However, till now, robust and reliable hypoxia-related prognostic signatures have not been established for an accurate prognostic evaluation in HNSCC patients. This article focused on establishing a risk score model to evaluate the prognosis and guide treatment for HNSCC patients. RNA-seq data and clinical information of 502 HNSCC patients and 44 normal samples were downloaded from The Cancer Genome Atlas (TCGA) database. 433 samples from three Gene Expression Omnibus (GEO) datasets were incorporated as an external validation cohort. In the training cohort, prognostic-related genes were screened and LASSO regression analyses were performed for signature establishment. A scoring system based on SRPX, PGK1, STG1, HS3ST1, CDKN1B, and HK1 showed an excellent prediction capacity for an overall prognosis for HNSCC patients. Patients were divided into high- and low-risk groups, and the survival status of the two groups exhibited a statistically significant difference. Subsequently, gene set enrichment analysis (GSEA) was carried out to explore the underlying mechanisms for the prognosis differences between the high- and low-risk groups. The tumor immune microenvironment was evaluated by CIBERSORT, ESTIMATE, TIDE, and xCell algorithm, etc. Then, we explored the relationships between this prognostic model and the levels of immune checkpoint-related genes. Cox regression analysis and nomogram plot indicated the scoring system was an independent predictor for HNSCC. Moreover, a comparison of predictive capability has been made between the present signature and existing prognostic signatures for HNSCC patients. Finally, we detected the expression levels of proteins encoded by six-HRGs via immunohistochemical analysis in tissue microarray. Collectively, a novel integrated signature considering both HRGs and clinicopathological parameters will serve as a prospective candidate for the prognostic evaluation of HNSCC patients.
A minimally-edited mouse model for infection with multiple SARS-CoV-2 strains

Efficient mouse models to study SARS-CoV-2 infection are critical for the development and assessment of vaccines and therapeutic approaches to mitigate the current pandemic and prevent reemergence of COVID-19. While the first generation of mouse models allowed SARS-CoV-2 infection and pathogenesis, they relied on ectopic expression and non-physiological levels of human angiotensin-converting enzyme 2 (hACE2). Here we generated a mouse model carrying the minimal set of modifications necessary for productive infection with multiple strains of SARS-CoV-2. Substitution of only three amino acids in the otherwise native mouse Ace2 locus (Ace2 TripleMutant or Ace2™), was sufficient to render mice susceptible to both SARS-CoV-2 strains USA-WA1/2020 and B.1. 1.529 (Omicron). Infected Ace2™ mice exhibited weight loss and lung damage and inflammation, similar to COVID-19 patients. Previous exposure to USA-WA1/2020 or mRNA vaccination generated memory B cells that participated in plasmablast responses during breakthrough B.1. 1.529 infection. Thus, the Ace2™ mouse replicates human disease after SARS-CoV-2 infection and provides a tool to study immune responses to sequential infections in mice.
Fermionization and bosonization of expanding one-dimensional anyonic fluids

Departamento de Qu´imica-F´isica, Universidad del Pa´is Vasco, Apartado 644, 48080 Bilbao, Spain(Dated: May 27, 2008)The momentum distribution of an expanding cloud of one-dimensional hard-core anyons is stud-ied by an exact numerical approach, and shown to become indistinguishable from that of a non-interacting spin-polarized Fermi gas for large enough times (dynamical fermionization). We alsoconsider the expansion of one-dimensional anyons with strongly attractive short-range interactionssuddenly released from a parabolic external potential, and ﬁnd that momentum distribution ap-proaches that of its dual system, the ideal Bose gas (dynamical bosonization). For both processesthe characteristic time scales are identiﬁed, and the eﬀect of the initial conﬁnement is analyzedcomparing the dynamics associated with both harmonic and hard-wall traps.
Oocyte-specific disruption of adrenomedullin 2 gene enhances ovarian follicle growth after superovulation

Background Adrenomedullin 2 (ADM2), adrenomedullin (ADM), and calcitonin gene-related peptides (α- and β-CGRPs) signal through heterodimeric calcitonin receptor-like receptor/receptor activity-modifying protein 1, 2 and 3 (CLR/RAMP1, 2 and 3) complexes. These peptides are important regulators of neurotransmission, vasotone, cardiovascular development, and metabolic homeostasis. In rodents, ADM is essential for regulating embryo implantation, fetal–placental development, and hemodynamic adaptation during pregnancy. On the other hand, ADM2 was shown to affect vascular lumen enlargement, and cumulus cell-oocyte complex (COC) communication in rodent and bovine ovarian follicles. To investigate whether oocyte-derived ADM2 plays a physiological role in regulating ovarian folliculogenesis, we generated mice with oocyte-specific disruption of the Adm2 gene using a LoxP-flanked Adm2 transgene (Adm2 loxP/loxP) and crossed them with Zp3-Cre mice which carry a zona pellucida 3 (Zp3) promoter-Cre recombinase transgene. Results While heterozygous Adm2 +/-/Zp3-Cre and homozygous Adm2 -/-/Zp3-Cre mice were fertile, Adm2 disruption in oocytes significantly increased the number of ovulated oocytes following a superovulation treatment. Oocyte-specific Adm2 disruption also significantly impaired the developmental capacity of fertilized eggs and decreased the size of the corpus luteum following superovulation, perhaps due to a reduction of ovarian cyclin D2-associated signaling. Conclusions The disruption of intrafollicular ADM2 signaling leads to follicular dysfunction. These data suggested that oocyte-derived ADM2 plays a facilitative role in the regulation of hormonal response and follicle growth independent of the closely related ADM and CGRP peptides, albeit in a subtle manner.