Miracle-dz/UniFAR-FTUs huggingface dataset:
on the key components of community-based interventions coordinating care in dementia: A qualitative systematic

Background: Interventions aiming to coordinate services for the community-based dementia population vary in components, organisation and implementation. In this review we aimed to investigate the views of stakeholders on the key components of community-based interventions coordinating care in dementia. Methods: We searched four databases from inception to June 2015; Medline, The Cochrane Library, EMBASE and PsycINFO, this was aided by a search of four grey literature databases, and backward and forward citation tracking of included papers. Title and abstract screening was followed by a full text screen by two independent reviewers, and quality was assessed using the CASP appraisal tool. We then conducted thematic synthesis on extracted data. Results: A total of seven papers from five independent studies were included in the review, and encompassed the views of over 100 participants from three countries. Through thematic synthesis we identified 32 initial codes that were grouped into 5 second-order themes: (1) case manager had four associated codes and described preferences for the case manager personal and professional attributes, including a sound knowledge in dementia and availability of local services; (2) communication had five associated codes and emphasized the importance stakeholders placed on multichannel communication with service users, as well as between multidisciplinary teams and across organisations; (3) intervention had 11 associated codes which focused primarily on the practicalities of implementation such as the contact type and frequency between case managers and service users, and the importance of case manager training and service evaluation; (4) resources had five associated codes which outlined stakeholder views on the required resources for coordinating interventions and potential overlap with existing resources, as well as arising issues when available resources do not meet those required for successful implementation; and (5) support had seven associated codes that reflect the importance that was placed on the support network around the case manager and the investment of professionals involved directly in care as well as the wider professional network. Conclusion: The synthesis of relevant qualitative studies has shown how various stakeholder groups considered dementia care coordination interventions to be acceptable, useful and appropriate for dementia care, and have clear preferences for components, implementation methods and settings of these interventions. By incorporating stakeholders ’ perspectives and preferences when planning and developing coordinating interventions we may increase the likelihood of successful implementation and patient benefits.
Chapter 30 HPSG and Lexical Functional Grammar

This chapter compares two closely related grammatical frameworks, Head-Driven Phrase Structure Grammar (HPSG) and Lexical Functional Grammar (LFG). Among the similarities: both frameworks draw a lexicalist distinction between morphology and syntax, both associate certain words with lexical argument structures, both employ semantic theories based on underspecification, and both are fully explicit and computationally implemented. The two frameworks make available many of the same representational resources. Typical differences between the analyses proffered under the two frameworks can often be traced to concomitant differences of emphasis in the design orientations of their founding formulations: while HPSG’s origins emphasized the formal representation of syntactic locality conditions, those of LFG emphasized the formal representation of functional equivalence classes across grammatical structures. Our comparison of the two theories includes a point by point syntactic comparison, after which we turn to an exposition of Glue Semantics, a theory of semantic composition closely associated with LFG.
The mutant p 53 -ID 4 complex controls VEGFA isoforms by recruiting lncRNA MALAT 1

The abundant, nuclear-retained, metastasis-associated lung adenocarcinoma transcript 1 (MALAT 1 ) has been associated with a poorly differentiated and aggressive phenotype of mammary carci-nomas. This long non-coding RNA (lncRNA) localizes to nuclear speckles, where it interacts with a subset of splicing factors and modulates their activity. In this study, we demonstrate that oncogenic splicing factor SRSF 1 bridges MALAT 1 to mutant p 53 and ID 4 proteins in breast cancer cells. Mutant p 53 and ID 4 delocalize MALAT 1 from nuclear speckles and favor its association with chromatin. This enables aberrant recruitment of MALAT 1 on VEGFA pre-mRNA and modulation of VEGFA isoforms expression. Interest-ingly, VEGFA-dependent expression signatures associate with ID 4 expression specifically in basal-like breast cancers carrying TP 53 mutations. Our results highlight a key role for MALAT 1 in control of VEGFA isoforms expression in breast cancer cells expressing gain-of-function mutant p 53 and ID 4 proteins. Recombinant human VEGFA b) a missense mutation in TP53 gene and High ID4 expression. Further investigation, focused on the examination of phosphorylation status of SRSF1 and intranuclear localization of MALAT1, in breast cancer sections, will allow the analysis of their association with TP53 status, ID4, VEGFA signature expression, and survival. In aggregate, our findings discover a novel mechanistic layer through which gain – of-function mutant p53 proteins enhance angiogenesis. Thus, the disassembling of the ribonucleoprotein complex comprising mutant p53/ID4/SRSF1/MALAT1 might hold therapeutic premise for mutant p53 breast cancers.
Bone Remodeling and Bone Grafting: Essentials of Synergism

: The majority of oral surgeries require using bone grafts due to the insufficient volume of the residual bone. To be able to make a decision on choosing a proper graft material, a surgeon should understand the whole chain of the processes which start from the graft insertion and go on. In this paper, the basic cellular and tissue mechanisms of bone formation, resorption, and remodeling are elucidated. The light is shed on the fundamentally different pathways of bone formation which occur both naturally in the course of ontogenesis and after any damage to bone has been done. Several histologic studies assessing the quality and quantity of newly formed bone when different bone grafting materials, such as autologous bone, autologous tooth, demineralized freeze-dried bone, and deproteinized bovine bone were used are included in this paper. The particles of most graft materials, except for autologous bone and tooth, to a greater extent remain unchanged within the newly formed bone matrix. This finding prompts further search for alternative materials which could completely integrate into the bone structure.
EVALUATION OF AXIAL LOAD-BEARING CAPACITY OF CONCRETE COLUMNS STRENGTHENED BY A NEW SECTION ENLARGEMENT METHOD

The objective of this study is to evaluate the axial load-bearing capacity of section-enlargement concrete columns. To reach the objection, a new strengthened method in which columns are jacketed with a large welded octagonal stirrup at the center and four spiral stirrups at the corners of column is developed. The new section-enlargement method avoids interrupting existing columns and improves the reliability of strengthened part, besides, the confining stress generated by octagonal stirrup and spiral stirrups enhances the compressive strength and deformability of strengthened columns. In addition, sixteen large-scale concrete columns strengthened by the new strengthened method were tested under axial compressive loads. The experimental results show that the axial compression ratio of existing column generates stress-strain lag in strengthened part and decreases the load-bearing capacity of specimens; the stirrups in strengthened part significantly enhance the axial load-bearing capacity of specimens. According to confinement conditions, the cross-section of specimens is divided into five parts and the confinement factor for each part is calculated to establish the prediction models for the load-bearing capacity of specimens. Furthermore, by comparing the results between the developed model and existing models, the developed model has high accuracy in evaluating the load-bearing capacity of strengthened columns.
Effects of street lighting technologies on the success and quality of pollination in a nocturnally pollinated plant

Arti ﬁ cial light at night (ALAN) is an increasingly important driver of global change. Lighting directly affects plants, but few studies have investigated indirect effects mediated by interacting organisms. Nocturnal Lepidoptera are globally important pollinators, and pollen transport by moths is disrupted by lighting. Many street lighting systems are being replaced with novel, energy-ef ﬁ cient lighting, with unknown ecological consequences. Using the wild ﬂ ower Silene latifolia , we compared pollination success and quality at experimentally lit and unlit plots, testing two major changes to street lighting technology: in lamp type, from high-pressure sodium lamps to light-emitting diodes, and in lighting regime, from full-night (FN) to part-night (PN) lighting. We predicted that lighting would reduce pollination. S. latifolia was pollinated both diurnally and nocturnally. Contrary to our predictions, ﬂ owers under FN lighting had higher pollination success than ﬂ owers under either PN lighting or unlit controls, which did not signi ﬁ cantly differ from each other. Lamp type, lighting regime, and distance from the light all signi ﬁ cantly affected aspects of pollination quality. These results con ﬁ rm that street lighting could affect plant reproduction through indirect effects mediated by nocturnal insects, and further highlight the possibility for novel lighting technologies to mitigate the effects of ALAN on ecosystems.
TRB3 is implicated in glucotoxicity- and ER-stress-induced beta-cell apoptosis

Abstract We found that TRB3, an endogenous inhibitor of Akt (PKB), is expressed in pancreatic -cells. The TRB3 expression is significantly increased in islets isolated from hyperglycemic GK rats comparing with normal-glycemic controls. In vitro high glucose treatment also resulted in increased TRB3 expression in rat INS-1 cells. To investigate the role of TRB3 in the regulation of -cell function, we established an INS-1 stable cell line allowing inducible expression of TRB3. We demonstrated that over-expression of TRB3 mimicked the glucotoxic effects on insulin secretion and cell growth in INS-1 cells. Moreover, induction of TRB3 also synergistically enhanced high glucose elicited apoptosis in INS-1 cells, whereas siRNA knock-down of TRB3 showed the opposite effects. We also confirmed that the mof mitochondria was decreased, caspase-3 activity was up-regulated and ROS content was increased in TRB3 over-expressing beta cells in high glucose condition. Most interestingly, the ER-stress-inducer, thapsigargin, mimicked the high glucose effects on up-regulation of TRB3 and generation of apoptosis in cultured INS-1 cells. These effects were specifically prevented by siRNA knock down of TRB3. We therefore conclude that TRB3 is implicated in glucotoxicity- and ER-stress-induced -cell failure. TRB3 could be a potential pharmacological target for prevention and treatment of type 2 diabetes.
Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4 CD45RC Cells and CD4 CD8 (cid:50) Thymocytes

Previous studies have shown that induction of autoimmune diabetes by adult thymectomy and split dose irradiation of PVG.RT1 u rats can be prevented by their reconstitution with peripheral CD4 (cid:49) CD45RC (cid:50) TCR- (cid:97) / (cid:98) (cid:49) RT6 (cid:49) cells and CD4 (cid:49) CD8 (cid:50) thymocytes from normal syngeneic donors. These data provide evidence for the role of regulatory T cells in the prevention of a tissue-specific autoimmune disease but the mode of action of these cells has not been reported previously. In this study, autoimmune thyroiditis was induced in PVG.RT1 c rats using a similar protocol of thymectomy and irradiation. Although a cell-mediated mechanism has been implicated in the pathogenesis of diabetes in PVG.RT1 u rats, development of thyroiditis is independent of CD8 (cid:49) T cells and is characterized by high titers of immunoglobulin (Ig)G1 antithyroglobulin antibodies, indicating a major humoral component in the pathogenesis of disease. As with autoimmune diabetes in PVG.RT1 u rats, development of thyroiditis was prevented by the transfer of CD4 (cid:49) CD45RC (cid:50) and CD4 (cid:49) CD8 (cid:50) thymocytes from normal donors but not by CD4 (cid:49) CD45RC (cid:49) peripheral T cells. We now show that transforming growth factor (TGF)- (cid:98) and interleukin (IL)-4 both play essential roles in the mechanism of this protection since administration of monoclonal antibodies that block the biological activity of either of these cytokines abrogates the protective effect of the donor cells in the recipient rats. The prevention of both diabetes and thyroiditis by CD4 (cid:49) CD45RC (cid:50) peripheral cells and CD4 (cid:49) CD8 (cid:50) thymocytes therefore does not support the view that the mechanism of regulation involves a switch from a T helper cell type 1 (Th1) to a Th2-like response, but rather relies upon a specific suppression of the autoimmune responses involving TGF- (cid:98) and IL-4. The observation that the same two cytokines were implicated in the protective mechanism, whether thymocytes or peripheral cells were used to prevent autoimmunity, strongly suggests that the regulatory cells from both sources act in the same way and that the thymocytes are programmed in the periphery for their protective role. The implications of this result with respect to immuno-logical homeostasis are discussed.
Cancer Stage at Diagnosis in HIV-infected People and Transplant Recipients

, Abstract Background— It is unknown whether immunosuppression results in more aggressive, advanced stage cancers. As cancer stage is influenced both by tumor biology and medical surveillance, we assessed cancer stage in HIV-infected individuals and solid organ transplant recipients, two immunosuppressed groups with differences in healthcare utilization. Methods— We used data on all cases of 15 cancer types, diagnosed during 1996–2010 in two studies that linked U.S. cancer registries to HIV and transplant registries. Odds ratios (ORs) for advanced (vs. local) disease were estimated comparing HIV and transplant populations to immunocompetent people in polytomous logistic regression models, adjusted for age, sex, race, registry and year. Results— A total of 8,411 of 4.5 million cancer cases occurred in HIV-infected people, and 7,322 of 6.4 million cancer cases occurred in transplant recipients. Compared to immunocompetent people with cancer, HIV-infected people were more likely to be diagnosed with distant stage lung (OR=1.13), female breast (OR=1.99), and prostate cancers (OR=1.57), while transplant recipients had fewer distant stage lung (OR=0.54), female breast (OR=0.75) and prostate cancers (OR=0.72). Both immunosuppressed populations had a shift toward advanced stage melanoma (ORs: HIV=1.97; immunosuppression in their progression. Additionally, we observed a shift for some common cancers toward later stages in HIV-infected individuals and toward earlier stages in transplant recipients, consistent with differential access to medical care or surveillance.
EFFECT OF HEAT ON THE ANTIBACTERIAL ACTIVITY OF HONEY ON BACTERIAL ISOLATES

In this study, the antibacterial activity of raw honey and commercially sold honey on Serratia marcescens, Proteus mirabilis and Vibrio cholera was evaluated. Raw honey which was gotten from farmers in Etche community and two processed honey (Rowse and Princenic global honey) were bought from a superstore. The different honey samples were divided into two set. The heated honey and the unheated honey. The heated honey samples were heated for three days in a water bath at 90 ºC. Their antibacterial activities were evaluated using the well in agar method. Different concentrations of the honey samples were transferred into 6mm holes in freshly prepared Mueller-Hinton agar plates which have been seeded with the test isolates. This was done in duplicates. The antibacterial activities of the different honey samples showed that the zones diameter increased with increased concentration with the 100% concentration having the highest zones of inhibition. The zone diameter (mm) of the heated raw honey at 100% concentration on Proteus, Serratia and Vibrio was 17.50±0.71, 21.50±0.71 and 19.50±0.71, respectively. Despite the difference in the zone diameter, there was no significant difference at P ≤0.05 in the zone diameters at the 100% concentration. The zone diameter of the unheated Raw honey at 100% concentration on Proteus, Serratia and Vibrio was 18.00±2.83, 28.50±7.78 and 22.00±0.00mm, respectively. The zone diameter (mm) of Rowse and Princein heated honey at 100% concentration on Proteus, Serratia and Vibrio were (20.00±0.00, 25.00±0.00, and 20.00±0.00mm) and (19.00±0.00, 26.00±1.41, and 24.50±3.54mm), respectively. More so, there was no significant difference of the efficiency of the Rows honey on the different isolates at 100% concentration. This is also similar to the PG honey at p = 0.005. The unheated honey showed higher zones of inhibition than the heated honey. Thus, the type of honey, the heat, the microorganism and the concentrations of honey were factors that affected the antimicrobial efficiency of the honey.
BQN: Busy-Quiet Net Enabled by Motion Band-Pass Module for Action Recognition

A rich video data representation can be realized by means of spatio-temporal frequency analysis. In this research study we show that a video can be disentangled, following the learning of video characteristics according to their spatio-temporal properties, into two complementary information components, dubbed Busy and Quiet. The Busy information characterizes the boundaries of moving regions, moving objects, or regions of change in movement. Meanwhile, the Quiet information encodes global smooth spatio-temporal structures defined by substantial redundancy. We design a trainable Motion Band-Pass Module (MBPM) for separating Busy and Quiet-defined information, in raw video data. We model a Busy-Quiet Net (BQN) by embedding the MBPM into a two-pathway CNN architecture. The efficiency of BQN is determined by avoiding redundancy in the feature spaces defined by the two pathways. While one pathway processes the Busy features, the other processes Quiet features at lower spatio-temporal resolutions reducing both memory and computational costs. Through experiments we show that the proposed MBPM can be used as a plug-in module in various CNN backbone architectures, significantly boosting their performance. The proposed BQN is shown to outperform many recent video models on Something-Something V1, Kinetics400, UCF101 and HMDB51 datasets.
Language Technologies for the Creation of Multilingual Terminologies. Lessons Learned from the SSHOC Project

This paper is framed in the context of the SSHOC project and aims at exploring how Language Technologies can help in promoting and facilitating multilingualism in the Social Sciences and Humanities (SSH). Although most SSH researchers produce culturally and societally relevant work in their local languages, metadata and vocabularies used in the SSH domain to describe and index research data are currently mostly in English. We thus investigate Natural Language Processing and Machine Translation approaches in view of providing resources and tools to foster multilingual access and discovery to SSH content across different languages. As case studies, we create and deliver as freely, openly available data a set of multilingual metadata concepts and an automatically extracted multilingual Data Stewardship terminology. The two case studies allow as well to evaluate performances of state-of-the-art tools and to derive a set of recommendations as to how best apply them. Although not adapted to the specific domain, the employed tools prove to be a valid asset to translation tasks. Nonetheless, validation of results by domain experts proficient in the language is an unavoidable phase of the whole workflow.
Intestinal and extra-intestinal cancers associated with inflammatory bowel disease

Inflammatory bowel disease (IBD) with its two most common entities, ulcerative colitis and Crohn’s disease, causes an increased risk of developing intestinal cancers. In fact, malignancies are the second most common cause of death after cardiovascular diseases in both genders of patients with IBD. Risk factors for colorectal cancer in IBD correlate with the duration of the disease, extent of disease, the association with primary sclerosing cholangitis, family history, and early age at onset. Patients with IBD also have an increased risk for developing a variety of extra-intestinal malignancies. In particular, lymphomas, mostly non-Hodgkin lymphomas and skin cancers, are more frequently observed in IBD patients. Longstanding inflammation and the degree of immunosuppression as a result of IBD treatment appear to be the main driving factors for IBD-related carcinogenesis. This review provides an update on the clinical and pathological features of IBD-related intestinal and extra-intestinal malignancies. Prolonged chronic inflammation is assumed to underlie the cause of colitis-associated gastrointestinal carcinomas, with oxidative stress-induced DNA damage resulting in the activation of procarcinogenic genes and silencing of tumor-suppressor pathways. Further studies on colitis-associated dysplasia and carcinoma can help to elucidate the important role of the immune system and microbiota in the development of these malignancies. The degree of immunosuppression generated from anti-inflammatory treatment appears to be the main driving factors for IBD-related extra-intestinal malignancies.
FORCED ATTENTION FOR IMAGE CAPTIONING

Author: Devarapalli, Hemanth. MS Institution: Purdue University Degree Received: December 2018 Title: Forced Attention for Image Captioning. Major Professor: Dr. Julia Rayz Automatic generation of captions for a given image is an active research area in Artificial Intelligence. The architectures have evolved from using metadata of the images on which classical machine learning was employed to neural networks. Two different styles of architectures evolved in the neural network space for image captioning: Encoder-Attention-Decoder architecture, and the transformer architecture. This study is an attempt to modify the attention to allow any object to be specified. An archetypical Encoder-Attention-Decoder architecture (Show, Attend, and Tell (Xu et al., 2015)) is employed as a baseline for this study, and a modification of the Show, Attend, and Tell architecture is proposed. Both the architectures are evaluated on the MSCOCO (Lin et al., 2014) dataset, and seven metrics: BLEU – 1, 2, 3, 4 (Papineni, Roukos, Ward & Zhu, 2002), METEOR (Banerjee & Lavie, 2005), ROGUE L (Lin, 2004), and CIDer (Vedantam, Lawrence & Parikh, 2015) are calculated. Finally, the statistical significance of the results is evaluated by performing paired t tests.
Some Elementary Properties of Kurzweil-Henstock-Stieltjes Integral on R n

Kurzweil-Henstock integral is a generalization of the Reimann integral. In this paper, we established the definition of Kurzweil-Henstock-Stieltjes integral on R n via gauge type approach where integrand and integrator are all real-valued functions defined on a compact interval in R n . Moreover, the Cauchy Criterion is established. To this end, some underlying simple properties of this integral are studied, specifically, uniqueness, linearity, monotonocity, integrability over a subset, and additivity. Results gathered in this paper may serve as a foundation to some related studies such as the notion of convergence with respect to this integral, and the formulation of the Saks-Henstock Lemma.