Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of spectral decomposition to detection of dispersion anomalies associated with gas saturation

For many years geophysicists have attempted to exploit attenuation measurements in exploration seismology, because attenuation is perhaps the seismic property most closely related to the saturating fluid. The routine application of such ideas has proven elusive, however, largely because of the difficulty experienced when we attempt to measure attenuation in reflection data. Recent developments in the application of spectral decomposition methods to seismic data have opened the possibility of making further progress in this direction.
Diffusive‐Dispersive Isotope Fractionation of Chlorinated Ethenes in Groundwater: The Key Role of Incomplete Mixing and Its Multi‐Scale Effects

Diffusive‐dispersive processes are ubiquitous in porous media with important implications for solute transport in many natural and engineered systems; however, their effects on isotope fractionation of organic contaminants in subsurface flow‐through systems is not well understood. In this study, we investigate the propagation of isotope shifts in groundwater systems, induced by lateral diffusive‐dispersive isotope fractionation, on carbon and chlorine isotope signatures of chlorinated ethene plumes at steady state. We consider three distinct spatial scales (i.e., pore, laboratory, and field scales) and explore isotope fractionation with high‐resolution pore‐scale simulations, flow‐through experiments, and field‐scale numerical modeling. The experimental lab‐scale investigation was carried out using cis‐dichloroethene (cis‐DCE) as model contaminant, whereas cis‐DCE and trichloroethene (TCE) were considered in the multi‐scale numerical simulations. The pore‐scale analysis of transverse displacement demonstrates significant isotope fractionation over a wide range of seepage velocities (0.1–10 m/day). The pore‐scale simulations illuminate the key role of incomplete mixing, which sustains isotopologue‐specific gradients in the pore channels and results in the strongest isotope fractionation (−6‰ for carbon; −10‰ for chlorine) at the fastest flow velocity. The outcomes of the flow‐through experiments support the key role of isotopologue‐specific aqueous diffusion also at the laboratory scale, where significant diffusive‐dispersive isotopic shifts were observed at the outlet of the setup. Finally, the detailed field‐scale numerical simulations, performed in a cross‐section of a heterogeneous aquifer, illustrate that the microscopic diffusion‐induced isotope fraction propagates at macroscopic scales.
The Influence of Platelet-Derived Growth Factors on the Proliferation of Germinal Epithelium After Local Irradiation with Electrons

Background: At present, the damage of male reproductive function caused by electron irradiation, as well as the development of methods for its correction are the relevant topics for further research. In fact, the effect of leukocyte-poor platelet-rich plasma (LP-PRP) growth factors are poorly investigated on different aspects of male fertility. Methods: In this study, Wistar rats were divided into four groups; I) control which were injected with saline; II and III) groups (n=65) whose testes were locally irradiated with electrons to a dose of 2 Gy (linear accelerator “NOVAC-11”); III) the group (n=30) which received LP-PRP for 11 weeks after irradiation; and IV) animals (n=30) which received only LP-PRP (conditional control). The testes were studied by histological, immunohistochemical (IHC), western blotting, and TUNEL methods using Ki-67, Bcl-2, and p53. Comparison between groups was performed and p<0.01 was set as the level of significance. Results: The results showed a decrease in the expression levels of Ki-67 and Bcl-2 besides an increase in p53-positive cells by the end of the experiment (p<0.01). After injection of LP-PRP, a gradual restoration of the proliferative activity of gametes was noted, which was confirmed by an increase in the proportion of Ki-67- and Bcl-2-positive germ cells (46.4±2.3, p<0.01 and 23.5±1.1, respectively, p<0.01). Conclusion: Ki-67 expression and TUNEL analysis in the testes revealed a modulation of the proliferative-apoptotic balance towards apoptosis of germ cells after 2 Gy local electron irradiation. A tendency to restore the proliferative-apoptotic balance was noted after LP-PRP injections as indicated by increase in Ki-67-positive germ cells.
Surgical management of aural hematoma in dog

The study was conducted at S A Quadery Teaching Veterinary Hospital (SAQTVH) in Chittagong Veterinary and Animal Sciences University (CVASU), Bangladesh from January, 2014 to June 2014 to conduct about the surgical management of aural hematoma in dog. A total number of 11 dogs were used for surgical management based on history and presenting clinical sings. A history of scratching of right ear since one month ago and swollen abnormal blood filled space under the skin of the ear flap of the dog, no history of external trauma, but intense head-shaking and abrupt increase in the size of the ear flap was noticed by owner of the dog. A thorough examination of the aural canal is carried out under general anesthetic to determine any underlying cause. A fusiform incision made into the skin of the inner pinna with a purse-string suture placed around the incision for closure. To compress the dead space that results from drainage of the hematoma including through and through sutures, or compressing the ear with various materials. The disease was predominant in male (54.54%) than female (45.45%). Local breed were more prone (90.90%) to this disease. The method of operation is considered to be useful as treatment in the field level. Asian Australas. J. Biosci. Biotechnol. 2017, 2 (3), 247-250
Using it my way: a qualitative perspective on the learning intention of social networking sites among older adults

ABSTRACT Studies show that social networking sites (SNS) are convenient for older adults to bond with friends and family without traveling and provide new opportunities for communication that can help older adults to avoid loneliness and social isolation. However, the numbers of SNS usage among older adults are fewer in less developed nations, which can be because only a small number of older adults know how to use SNS, and difficulties such as fears and insecurities while trying to use SNS. To increase the number of older adults using SNS in Malaysia, this study explored the experiences that could affect the intention to learn SNS in older adults in using SNS. Phenomenology approaches using semi-structured one-to-one interviews were used to explore the factors that could affect the intention to learn SNS among older Malaysian adults. This study employed a qualitative approach to explore the intention to learn SNS of twelve older adults aged 60 to 73, residing in different regions of Malaysia. Thematic analysis was used to identify the themes and interpret the data after the data saturation was reached. The themes that emerged from the data were the ‘perceived usefulness,’ ‘unrealistic dependency,’ and ‘ignorant. ’ The results of this study can be used to come up with policies and strategies to encourage the learning of SNS among older adults. Program developers and trainers can also use the results of this study to develop modules that are more suited for older adults.
ON THE ASYMPTOTIC CURVES OF A SURFACE.

hand, conditions sufficient for the truth of the classical statements will be developed in terms which take into account the specifically geometrical origin of the various differential equations defining the respective problems. Oii the other hand, examples will show that the conditions to be imposed cannot be omitted. Both an attraction and a difficulty of the theory is the circumstance that, even if the surface has a parametrization in terms of asymptotic curves, examples show that this parametrization of the surface can be less differentiable than some other parametrization of the surface (or, equivalently, less smooth than the parametrization z = z (x, y), where x, y, z are Cartesian coordinates). Surfaces of negative Gaussian curvature are dealt with in Parts I, II, III. Part IV deals with lines of curvature and applies therefore to surfaces of positive curvature also. Finally, Part V develops the corresponding theory
Altered Lnc-EGFR, SNHG1, and LincRNA-Cox2 Profiles in Patients with Relapsing-Remitting Multiple Sclerosis: Impact on Disease Activity and Progression

Relapsing–remitting multiple sclerosis (RRMS) is the most prevalent MS subtype. Ample evidence has indicated that long noncoding RNAs (lncRNAs) are crucial players in autoimmune and inflammatory disorders. This study investigated the expression of lnc-EGFR, SNHG1, and lincRNA-Cox2 in RRMS patients during active relapses and in remission. Additionally, the expression of FOXP3, a master transcription factor for regulatory T cells, and NLRP3-inflammasome-related genes were determined. Relationships between these parameters and MS activity and annualized relapse rate (ARR) were also evaluated. The study included 100 Egyptian participants: 70 RRMS patients (35 during relapse and 35 in remission) and 30 healthy controls. RRMS patients showed significant downregulation of lnc-EGFR and FOXP3 and dramatic upregulation of SNHG1, lincRNA-Cox2, NLRP3, ASC, and caspase-1 compared to controls. Lower serum TGF-β1 and elevated IL-1β levels were observed in RRMS patients. Notably, patients during relapses displayed more significant alterations than those in remission. Lnc-EGFR was positively correlated with FOXP3 and TGF-β1 and negatively correlated with ARR, SNHG1, lincRNA-Cox2, and NLRP3 inflammasome components. Meanwhile, SNHG1 and lincRNA-Cox2 were positively correlated with ARR, NLRP3, ASC, caspase-1, and IL-1β. Excellent diagnostic performance for lnc-EGFR, FOXP3, and TGF-β1 was demonstrated, while all biomarkers exhibited strong prognostic potential for predicting relapses. Finally, the differential expression of lnc-EGFR, SNHG1, and lincRNA-Cox2 in RRMS patients, especially during relapses, suggests their involvement in RRMS pathogenesis and activity. Correlation between their expression and ARR implies relationships to disease progression. Our findings also highlight their promising roles as biomarkers for RRMS.
Theranostics of Primary Prostate Cancer: Beyond PSMA and GRP-R

Simple Summary The accurate assessment of the aggressiveness and localization of primary prostate cancer lesions are essential for treatment decision making. Around 15% of lesions are missed by PSMA Positron-Emission tomography/computed Tomography (PET/CT). The aim of our study was to investigate the potential of novel surface markers to detect PSMA-negative lesions using immunohistochemistry and autoradiography techniques. Our work demonstrates that targeting both PSMA and neurotensin receptors might detect all intra-prostatic lesions. This new finding has implications for the future theranostics of primary prostate cancer. Abstract The imaging of Prostate-Specific Membrane Antigen (PSMA) is now widely used at the initial staging of prostate cancers in patients with a high metastatic risk. However, its ability to detect low-grade tumor lesions is not optimal. Methods: First, we prospectively performed neurotensin receptor-1 (NTS1) IHC in a series of patients receiving both [68Ga]Ga-PSMA-617 and [68Ga]Ga-RM2 before prostatectomy. In this series, PSMA and GRP-R IHC were also available (n = 16). Next, we aimed at confirming the PSMA/GRP-R/NTS1 expression profile by retrospective autoradiography (n = 46) using a specific radiopharmaceuticals study and also aimed to decipher the expression of less-investigated targets such as NTS2, SST2 and CXCR4. Results: In the IHC study, all samples with negative PSMA staining (two patients with ISUP 2 and one with ISUP 3) were strongly positive for NTS1 staining. No samples were negative for all three stains—for PSMA, GRP-R or NTS1. In the autoradiography study, binding of [111In]In-PSMA-617 was high in all ISUP groups. However, some samples did not bind or bound weakly to [111In]In-PSMA-617 (9%). In these cases, binding of [111n]In-JMV 6659 and [111In]In-JMV 7488 towards NTS1 and NTS2 was high. Conclusions: Targeting PSMA and NTS1/NTS2 could allow for the detection of all intraprostatic lesions.
Efficacy of bioresorbable plating system in the treatment of pediatric maxillary fractures: A short clinical study

ABSTRACT Aim: The aim of this study was to evaluate the efficacy, stability, and clinical outcomes of a bioresorbable plating system in the treatment of pediatric maxillary fractures. Materials and Methods: Twenty pediatric patients with maxillary fractures (13 males and 7 females) were included in this study. The 1.5- and 2.0-mm resorbable plates were used and secured with monocortical resorbable screws 6 mm and 7 mm in length. All patients were followed up for 6 months. Clinical parameters, such as pain, swelling, soft-tissue infection, malocclusion, nerve injury, and bite force for stability, were prospectively assessed. Results: Fall from height (50%) was the most common cause of etiology, followed by road traffic accidents (35%). Maxillary alveolar # (40) was the most common fracture site, followed by nasal complex # (25%) and zygomatic complex # (25%). Appropriate fixation and adequate primary bone healing was achieved in 100% of the cases. Few minor complications were observed: (1) soft-tissue infection (5%) and (2) paresthesia (10%). There was a significant increase in bite force in the incisor and molar regions. Observation in clinical parameters shows that there was a significant reduction in postoperative pain and swelling at different follow-up periods. Conclusion: Bioresorbable plating system is used as a load-sharing plate in a semirigid fixation technique after anatomic fracture reduction. Although its high costs limit its feasibility for use low infection rates, minimized second surgery for implant removal attracts its use. 1.5- and 2-mm resorbable plating system along is a good treatment modality for moderately displaced maxillary fractures in pediatric patients. Larger sample size and longer follow-up studies are required for conclusive results.
Models of the very early universe with multiple scalar fields

There is a reasonable amount of observational evidence that suggests space was expanding exponentially in the very early universe --- an expansion that has become known as inflation. The mechanism by which this happens remains up for debate, however, and this thesis looks at a number of potential scenarios using multiple scalar fields to drive the expansion. There are two studies that look at how additional couplings either between the fields themselves or to gravity can influence the observable consequences of inflation on the Cosmic Microwave Background and one which tries to extend a gravitational coupling to explain the current expansionary epoch caused by dark energy. The importance of reheating in such scenarios is also investigated. In the case of a non-canonical kinetic coupling, an approximation is used to show how the curvature perturbation can evolve on super-horizon scales to a much improved accuracy over previous work. The gravitational coupling results in a vast increase in the amplitude of the curvature power spectrum via the non-adiabatic pressure perturbation and, finally, the attempts to link this to dark energy are demonstrated to be much more difficult than one might initially assume.
Compliance with the Implementation of Health Protocols During the COVID-19 Pandemic for Employees in Hospitals

RSUD Depati Hamzah (hospital) is a referral hospital for COVID-19 patients. Efforts need to be carried out to prevent and control COVID-19 for employees because it is categorized as a workplace with a high risk of exposure or high potential for close contact with people or patients who are known or suspected to be infected with COVID-19. Non-compliance with implementing health protocols can potentially expand the spread of COVID-19. The purpose of the research is to determine employees' compliance with the implementation of health protocols during the COVID-19 pandemic at RSUD Depati Hamzah. This research is analytical with a quantitative approach with a cross-sectional design. This study's population was all RSUD Depati Hamzah members, and the sample number was 94 respondents. Hospitals need to increase socialization about the impact of COVID-19 disease. It should provide complete facilities and infrastructure in all parts of the work that support the implementation of employee compliance in preventing the transmission of COVID-19, such as symbols or signs of social distancing, posters to provide education and remind employees and visitors of hospital junk about COVID-19.
The Nutritional Quality of Food Provision at UK Government-Funded Holiday Clubs: A Cross-Sectional Analysis of Energy and Nutrient Content

A large proportion of children are at risk of food insecurity during school holidays in the UK. The government-funded Holiday Activities and Food (HAF) programme provides free holiday clubs offering at least one healthy meal/day to eligible children and adolescents. This study aims at evaluating the nutritional quality of food provision at HAF holiday clubs, particularly hot/cold and vegetarian/non-vegetarian meals. Menu variants (n = 2759) from 49 HAF holiday clubs were assessed for adherence to School Food Standards (SFS) and their notional compositional quality, which was scored utilising a novel nutrient-based meal quality index. The median adherence to SFS across all available menus was 70% (IQR 59–79%). Overall, hot variants scored statistically higher menu quality scores than cold variants for both 5–11y (92.3 (80.7–102.7) vs. 80.4 (69.3–90.6)) and 11–18y (73.5 (62.5–85.8) vs. 58.9 (50.0–70.7)) criteria. Cold and hot menu variants tended to score differentially for quality sub-components. These findings highlight areas for potential future improvement in HAF holiday club provision with a tendency for food provision to appear less ideal for attendees for those aged 11–18. Ensuring that children from low-income households have access to a healthy diet is crucial to reduce UK health inequalities.
Experimental Investigations of Boundary Layer Thickness Using Ultrasonic Transit Time Method

The widely used investigation method of fluid boundary layer is to record or simulate the current profile distributions near boundary, and then the loss of velocity can be estimate by integration. A directly measuring method of boundary layer displacement thickness by using ultrasonic transit time instrument is proposed. The problem of boundary layer measurement can be simplified to a easier measurement process of current velocity calibration, and the verification experiments are carried out by taking smooth plate as an example. An experimental platform of towing tank facility is established, the towing velocity is taken as the standard value of the outflow speed. The device for flat plate boundary layer measurement is regarded as an ultrasonic current meter. The inner side of the pair of plates equipped with ultrasonic probes can be considered as smooth surface, when the concave at the end of probes, installed by path axial angle, is filled with the material, which acoustic impedance is approximately equal to water. The measured value of ultrasonic current meter is equivalent to the difference between the outflow velocity and the loss caused by boundary layer. The accuracy of measurement result is ensured through high-precision geometric measurement, time delay calibration and sufficient zero-offset correction. In order to improve the time measurement resolution of the current meter, the range of flow velocity is set higher than 100mm/s. By changing the towing velocity and the characteristic position of ultrasonic probe installation, the Reynolds number range is 5e4 to 5e5. By analyzing the principle of ultrasonic current meter and towing tank facility, the uncertainty of displacement thickness measurement results can be properly evaluated. The measurement results of these experiments are close to the integration of flow field record by LDA.
Nuciferine Effectively Protects Mice against Acetaminophen-Induced Liver Injury

Acetaminophen (APAP) overdose still poses a major clinical challenge and is a leading cause of acute liver injury (ALI). N-acetylcysteine (NAC) is the only approved antidote to treat APAP toxicity while NAC therapy can trigger side effects including severe vomiting and even shock. Thus, new insights in developing novel therapeutic drugs may pave the way for better treatment of APAP poisoning. Previous research has reported that nuciferine (Nuci) possesses anti-inflammatory and antioxidant properties. Therefore, the objective of this study was proposed to investigate the hepatoprotective effects of Nuci and explore its underlying mechanisms. Mice were intraperitoneally (i.p.) administered with APAP (300 mg/kg) and subsequently injected with Nuci (25, 50, and 100 mg/kg, i.p.) at 30 min after APAP overdose. Then, all mice were sacrificed at 12 h after APAP challenge for further analysis. Nuci-treated mice did not show any side effects and our results revealed that treating Nuci significantly attenuated APAP-induced ALI, as confirmed by histopathological examinations, biochemical analysis, and diminished hepatic oxidative stress and inflammation. The in silico prediction and mRNA-sequencing analysis were performed to explore the underlying mechanisms of Nuci. GO and KEGG enrichment of the predicted target proteins of Nuci includes reactive oxygen species, drug metabolism of cytochrome P450 (CYP450) enzymes, and autophagy. Furthermore, the mRNA-sequencing analyses indicated that Nuci can regulate glutathione metabolic processes and anti-inflammatory responses. Consistently, we found that Nuci increased the hepatic glutathione restoration but decreased APAP protein adducts in damaged livers. Western blot analysis further confirmed that Nuci effectively promoted hepatic autophagy in APAP-treated mice. However, Nuci could not affect the expression levels of the main CYP450 enzymes (CYP1A2, CYP2E1, and CYP3A11). These results demonstrated that Nuci may be a potential therapeutic drug for APAP-induced ALI via amelioration of the inflammatory response and oxidative stress, regulation of APAP metabolism, and activation of autophagy.
Low-temperature single crystal reflection spectra of forsterite

The infrared reflectivities of crystalline forsterite (Mg 2 SiO 4 ) were measured for the temperature range 295-50 K for each crystal axis, between wavenumber 5000 and 100 cm -1 . The reflection spectra show clear dependence of temperature; most of the bands become more intense, sharper and their peak positions shift to higher wavenumber with decreasing temperature. Reflection spectra were fitted with dispersion formula of damped oscillator model of the dielectric constants and the oscillator parameters in the model were derived. The absorption spectra of forsterite particle are calculated with the derived dielectric constants to show that the forsterite features are good thermal indicator for cold temperature range below 295 K.