Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal, Location- and Symptom-Specific Likelihood of Patient-Reported Sensory Symptoms Related to Oxaliplatin-Induced Peripheral Neuropathy (OIPN) in Patients Receiving Oxaliplatin for Three Months

Simple Summary There are no known effective preventative interventions for oxaliplatin-induced peripheral neuropathy (OIPN) sensory symptoms of numbness, tingling and pain other than limiting drug exposure. With the shorter 3-month duration of oxaliplatin increasingly being used, compared to the previous 6-month standard, we were motivated to quantify the temporal, location- and symptom-specific likelihood of patient-reported sensory symptoms related to OIPN in 141 patients from the placebo arms of two multisite OIPN prevention trials exposed to oxaliplatin for 3 months. Despite a shorter duration of oxaliplatin, we show that OIPN was still pervasive, with patients experiencing considerable mild to moderate numbness and tingling in the lower and upper distal extremities. To avoid the debilitating sequelae from OIPN and to ensure that patients continue to receive the most efficacious doses of oxaliplatin, identification of effective OIPN preventative interventions is still needed, regardless of whether oxaliplatin is planned to be given for 3 versus 6 months. Abstract While oxaliplatin-induced peripheral neuropathy (OIPN) is more common and severe in patients who receive the previous standard, 6-month oxaliplatin-based treatment, we hypothesized that OIPN was still pervasive in patients who received shorter, 3-month-treatment regimens. Using six EORTC QLQ-CIPN20 questions that quantify numbness (N), tingling (T) and shooting/burning pain (P) in upper/lower distal extremities, our aim is to quantify patient-reported responses over 3 months (6 cycles) of oxaliplatin regarding symptom-specific timing, location and severity. For each question, patients were asked how each of the sensory symptoms had affected them during the preceding week, with 1 = “Not at all”, 2 = “A little”, 3 = “Quite a bit” and 4 = “Very much”. The proportional odds model for the cumulative log odds of response that allowed symptom-specific patient heterogeneity to be obtained was applied to a pooled dataset from the placebo arms of two multisite OIPN prevention trials and fit separately to the upper/lower distal extremities. For each symptom, we report the cycle-specific marginal probabilities for each response. In 141 patients, substantial patient heterogeneity in the likelihood, at a given cycle, of a more severe response for a symptom was present. Distinct patterns in the probabilities for each response over time for N and T were observed between the upper/lower distal extremities, while the probabilities of a response >1 for P was largely negligible in both locations. Despite the decrease in exposure to oxaliplatin from 6 to 3 months, OIPN was still pervasive with patients experiencing considerable N and T in the fingers (or hands) and toes (or feet).
THE EFFECTIVENESS OF TRAINING FROM HOME ON VO2MAX FEMALE VOLLEYBALL ATHLETES

This study aims to determine the effectiveness of Training From Home (TFH) on vo2max female volleyball athletes at SMP Negeri 13 Gorontalo City. This study uses a quasi-experimental approach that uses a population of all female athletes at SMP Negeri 13 Gorontalo, totaling 16 athletes, who were then divided into an experimental group and a control group of 8 athletes each who were randomly selected. This instrument uses the Multistage Fitness Test (MFT) and uses skipping as a treatment. Analysis of research data using paired sample t-test or t-test using SPSS 20. The results of this study can be concluded that there is a significant difference in the effectiveness of TFH exercise on VO2Max
Tropical Soil Bacterial Diversity in Sabah, Malaysia

Bacteria are an essential biological component of soil function that plays fundamental roles in biogeochemical cycling, soil quality improvement, habitat-shaping, and ecosystem conservation. It is therefore important to have a good record of soil bacteria in the tropics in order to monitor future changes that may occur due to global warming and other factors. However, extremely limited data are available on the diversity of bacteria in soils in some tropical Borneo regions such as Sabah, Malaysia. This research, therefore, was undertaken to determine the bacterial diversity of soils from various locations in Sabah, Malaysia. Ten soil samples (n=10) were collected around Sabah. 16S rDNA of bacterial DNA extracted from soils were amplified and analysed using the Denaturing Gradient Gel Electrophoresis (DGGE). A total of 100 dominant and well-defined DNA fragments observed in the DGGE gel were extracted, sequenced, and aligned. The results indicated that 93 different bacterial operational taxonomic units (OTUs) representing bacteria from 8 different phyla were present. The most abundant phyla in the analysed Sabah soils were Proteobacteria followed by Acidobacteria, Firmicutes, Actinobacteria, Planctomycetes, Verrucomicrobia, Chloroflexi, and Bacteroidetes. The examined soils of Sabah and Peninsular Malaysia had similar dominant phyla in general, except that the most dominant phylum in Peninsular Malaysia soils is the Acidobacteria instead of Proteobacteria. These baseline data generated from this work are important and can be used to track bacterial diversity shifts due to soil or environmental changes in the future.
Comparison of Co-located and Distributed MIMO for Indoor Wireless Communication

This paper compares the communication performance for co-located and emerging distributed MIMO in a typical indoor scenario. The simulations, which are verified against experimental measurement data, show that distributed MIMO offers a significantly more uniform capacity for the users. The results also show that the same user capacity can be achieved with half the number of antennas in the distributed MIMO case.
Iterative method of reconstructing the size distribution function of spherical nanoparticles based on the intensity of the small-angle X-ray scattering including the interference contribution to the intensity

PACS 61.10. Eq, 61.43. Gt, 61.46. +w ABSTRACT It has been shown that for systems of polydisperse spherical particles the interference distortions of the scattering intensity significantly affect the result of reconstructing the particle size distribution when the volume fraction of the scattering substance is higher than 10 %. We have developed an iterative method that reconstructs the size distribution function from the small-angle X-ray scattering intensity with interference distortions. The efficiency of this method is confirmed based on simulated scattering intensities and experimentally measured intensities of samples with a volume fraction of a scattering substance up to 40 %.
Effects and safety of COVID-19 vaccination on assisted reproductive technology and pregnancy: A comprehensive review and joint statements of the KSRM, the KSRI, and the KOSAR

Humanity is in the midst of the coronavirus disease 2019 (COVID-19) pandemic, and vaccines—including mRNA vaccines—have been developed at an unprecedented speed. It is necessary to develop guidelines for vaccination for people undergoing treatment with assisted reproductive technology (ART) and for pregnancy-related situations based on the extant laboratory and clinical data. COVID-19 vaccines do not appear to adversely affect gametes, embryos, or implantation; therefore, active vaccination is recommended for women or men who are preparing for ART. The use of intravenous immunoglobulin G (IVIG) for the treatment of immune-related infertility is unlikely to impact the effectiveness of the vaccines, so COVID-19 vaccines can be administered around ART cycles in which IVIG is scheduled. Pregnant women have been proven to be at risk of severe maternal and neonatal complications from COVID-19. It does not appear that COVID-19 vaccines harm pregnant women or fetuses; instead, they have been observed to deliver antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the fetus. Accordingly, it is recommended that pregnant women receive COVID-19 vaccination. There is no rationale for adverse effects, or clinical cases of adverse reactions, in mothers or neonates after COVID-19 vaccination in lactating women. Instead, antibodies to SARS-CoV-2 can be delivered through breast milk. Therefore, breastfeeding mothers should consider vaccination. In summary, active administration of COVID-19 vaccines will help ensure the safe implementation of ART, pregnancy, and breastfeeding.
Queuing Analysis of QoS Aware Microwave Power Transfer Enabled CR-IoT Network

We analyze a Cognitive Radio-based Internet-of-Things (CR-IoT) network employing Microwave Power Transfer (MPT) method for energy-harvesting, targeted for smart city applications. In our model, multiple IoT sensors, operated by an IoT operator, coexist with a Primary Network Provider (PNP), where the IoT sensors opportunistically exploit the spectrum holes in the PNP’s licensed band. We develop an Imbedded Markov Chain based approach to analyze this system. During PNP’s inactivity periods, the Accesss Points (APs) under the IoT operator have to judiciously use PNP’s licensed band for data collection from the IoT sensors and charging them via the MPT method. Our analysis finds the balance between these activities while maintaining the Quality-of-Service and preventing energy deficit in the IoT sensors. We characterize PNP’s activity using any distribution, rather than exponential distribution used in literature, making our framework more accurate. We also consider the possibility of interruptions in the IoT operator’s activity due to PNP’s transmission, which has been overlooked in the literature. Extensive simulations demonstrate the accuracy of our analysis. Our analysis can identify the values of system parameters that makes the system sustainable. We have also shown how to extend our model to accommodate multiple PNPs in the same CR-IoT network.
Characteristics of Infrastructure and Surrounding Geo-Environmental Circumstances Involved in Fatal Incidents Caused by Flash Flooding: Evidence from Greece

Recent studies have shown that a large portion of flood-associated fatalities are related to the use of vehicles. However, there is limited research on the role of infrastructure and geo-environmental conditions surrounding such incidents. This work exploits a dataset of 40 fatal vehicle-related events caused by flooding in Greece to explore the circumstances, the characteristics of infrastructure and of the surrounding environment and their possible influence in the studied incidents. The results showed that the majority of cases occurred in road segments and river crossings with a variety of design deficiencies related to safety and protection from flooding, including poor signage and lighting as well as the absence of road closures, road barriers and other crucial safety features. In high percentages incidents occurred in isolated/remote sites in rural areas, relatively narrow roads and low quality infrastructure (e.g., ford crossings) with a lack of easy alternate routes and absence of other individuals. In the vast majority of cases, the accidents occurred in small arid catchments drained by ephemeral torrents when experiencing extreme flows. The findings have practical implications as they provide a better understanding of dangerous circumstances and define the high-risk segments of the road, which is helpful in prioritizing and shaping appropriate interventions.
Latent Heterogeneity in the Impact of Financial Coaching on Delay Discounting among Low-Income Smokers: A Secondary Analysis of a Randomized Controlled Trial

Low-income adults are significantly more likely to smoke, and face more difficulty in quitting, than people with high income. High rates of delay discounting (DD) may be an important factor contributing to the high rates of tobacco use among low-income adults. Future-oriented financial coaching may offer a novel approach in the treatment of smoking cessation among low-income adults. This secondary analysis (N = 251) of data from a randomized controlled trial examined the integration of future-oriented financial coaching into smoking cessation treatment for low-income smokers. Linear regression and finite mixture models (FMM) estimated the overall and the latent heterogeneity of the impact of the intervention versus usual care control on DD rates 6 months after randomization. Though standard linear regression found no overall difference in DD between intervention and control (β = −0.23, p = 0.338), the FMM identified two latent subgroups with different responses to the intervention. Subgroup 1 (79% of the sample) showed no difference in DD between intervention and control (β = 0.25, p = 0.08). Subgroup 2 (21% of the sample) showed significantly lower DD (β = −2.06, p = 0.003) among intervention group participants versus control at 6 months. Participants were more likely to be a member of subgroup 2 if they had lower baseline DD rates, were living at or below 100% of federal poverty, or were married/living with a partner. This study identified a group of low-income adults seeking to quit smoking who responded to financial coaching with decreased DD rates. These results can be used to inform future targeting of the intervention to individuals who may benefit most, as well as inform future treatment adaptations to support the subgroup of low-income smokers, who did not benefit.
Nanomedicine as a Promising Tool to Overcome Immune Escape in Breast Cancer

Breast cancer is the most common type of malignancy and leading cause of cancer death among women worldwide. Despite the current revolutionary advances in the field of cancer immunotherapy, clinical response in breast cancer is frequently below expectations, in part due to various mechanisms of cancer immune escape that produce tumor variants that are resistant to treatment. Thus, a further understanding of the molecular events underlying immune evasion in breast cancer may guarantee a significant improvement in the clinical success of immunotherapy. Furthermore, nanomedicine provides a promising opportunity to enhance the efficacy of cancer immunotherapy by improving the delivery, retention and release of immunostimulatory agents in targeted cells and tumor tissues. Hence, it can be used to overcome tumor immune escape and increase tumor rejection in numerous malignancies, including breast cancer. In this review, we summarize the current status and emerging trends in nanomedicine-based strategies targeting cancer immune evasion and modulating the immunosuppressive tumor microenvironment, including the inhibition of immunosuppressive cells in the tumor area, the activation of dendritic cells and the stimulation of the specific antitumor T-cell response.
Nutrigenomics in Animal Feeding: Digital Gene Expression Analysis in Poultry Fed Tenebrio molitor Larvae Meal

The purpose of this study was to investigate the effects of high levels of Tenebrio molitor dietary inclusion (15%) on molecular mechanisms that influence poultry health in a broiler chicken diet. The global gene expression of four tissues (breast, liver, jejunum, and caecum) was evaluated using the RNA-Seq approach. The analysis of differentially expressed genes suggested that the use of Tenebrio molitor leads to the overexpression of genes related to protein elongation required for tissue growth and development in the gut and liver. It would also appear to contain nutrients that reduce the expression of genes related to the immune system and inflammation of the mucosa. The dietary inclusion of Tenebrio molitor in poultry could also lead to a possible inactivation of the growth factor and a reduction of tissue free-radicals. No genes alterations have been detected in liver RNA expression that would discourage the use of larvae in feeding broilers.
Restoring ergodicity of stochastically reset anomalous-diffusion processes

Wei Wang ,1,2,* Andrey G. Cherstvy ,2,3,† Ralf Metzler ,2,‡ and Igor M. Sokolov 3,4,§ 1Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany 2Institute of Physics & Astronomy, University of Potsdam, Karl-Liebknecht-Straße 24/25, 14476 Potsdam-Golm, Germany 3Institut für Physik, Humboldt-Universität zu Berlin, Newtonstraße 15, 12489 Berlin, Germany 4IRIS Adlershof, Zum Großen Windkanal 6, 12489 Berlin, Germany
The Impact of Teacher, School, and Student Factors on Standardized Student Test Scores Using Multidimensional Approach

This study examines the effect of teacher (race, salary, and experience), school (climate and Financial Efficiency Star Rating), and student (attendance and mobility) factors on student Math and ELA standardized test scores in elementary (n = 1140) and middle (n = 451) public schools across the state of Georgia. The data used in this study was collected by Georgia Department of Education (GaDOE) during the 2018-2019 school year. Three multivariate linear regression models are utilized to explore the main and interaction effects within and between factors. The first model analyzes the main effects of the three independent variables (teacher, school, and student) separately and then in a single combined model accounting for all factors. Individual model approach reveals strong positive correlations with Math and ELA test scores for all factors. However, the impact of each factor is greatly diminished in a combined model approach. The second model reveals that the interaction effects within factors does not impact student test scores significantly. Meanwhile, results from the third model show that the interactions between the three independent variables yield a modest impact on student test scores. Findings from this study can guide educators and policymakers to focus on factors that can improve student standardized test scores and meet the accountability mandate for school achievement as set by the Every Student Succeeds Act (ESSA) of 2015 and its predecessor No Child Left Behind (NCLB) Act of 2001.
Influence of the Sludge Retention Time on Membrane Fouling in an Anaerobic Membrane Bioreactor (AnMBR) Treating Lipid-Rich Dairy Wastewater

This study evaluated the effects of sludge retention time (SRT) on the membrane filtration performance of an anaerobic membrane bioreactor (AnMBR) fed lipid-rich synthetic dairy wastewater. The membrane filtration performance was evaluated in two AnMBR systems operated at two different SRTs, i.e., 20 and 40 days. For the AnMBR operated at 40 days, SRT exhibited worse membrane filtration performance characterized by operational transmembrane pressures (TMP) exceeding the maximum allowed value and high total resistances to filtration (Rtotal). The sludge in the two reactors evaluated at the different SRTs showed similar sludge filterability properties. However, the sludge in the reactor operated at 40 days SRT was characterized by exhibiting the highest concentrations of: (i) total suspended solids (TSS), (ii) small-sized particles, (iii) extracellular polymeric substances (EPS), (iv) soluble microbial products (SMP), (v) fats, oils and grease (FOG), and (vi) long-chain fatty acids (LCFA). The cake layer resistance was the major contributor to the overall resistance to filtration. The high TSS concentration observed in the AnMBR systems apparently contributed to a less permeable cake layer introducing a negative effect on the membrane filtration performance.
Colour of polyurethane foams filled with wood and wood derivatives exposed to two xylophagous fungi

This study addresses changes in aesthetical features of bio-based polyurethane (PU) foams filled with four forest-based particles (namely wood flour, wood bark, kraft lignin, and paper sludge), which were decayed by two wood-rot fungi. White-rot and brown-rot fungi were inoculated on these foams and further characterization results were obtained using colourimetric parameters measured according to the CIELab method. The fungi penetrated into both intra and intercellular spaces into the PU foams, although it neither changed the foam weight nor chemically interacted with the polymer cell wall. These fungi changed overall the appearance of the foams, which indicates that a protective strategy against these microorganisms may be of interest, especially for foam parts used in contact with wood products. The neat PU presented smaller colour stability if compared to the filled foams. Among the fillers, powdered kraft lignin stood out and can be indicated to produce valuable darkened PU parts with stable colour patterns.
Unerroric Automatic Control of Civil Hydroacousticer’s Working Quality on Board

The collision of a dry cargo ship with a submarine off Cape Ashizuri this year has actualized the study of the possibility of unerroric control of readiness of passenger and merchant ships to extreme variants of hydroacoustic conditions. The purpose of the research is to develop digital methods and algorithms of automatic quality control of ship’s hydroacousticer. The possibility of such control by multilevel estimation of results within training hydroacousticer on board of the ship is investigated. Recurrent methods and algorithms of formation of final and intermediate estimations of results of such training in a training mode within functioning of on board hydroacoustic means are offered and developed. These methods and algorithms allow complicating the simulation model of hydroacoustic environment fraught with ship accidents.
Development of a Coaching System for Functional Electrical Stimulation Rowing: A Feasibility Study in Able-Bodied Individuals

Background: Functional electrical stimulation (FES) during rowing has substantial effects on cardiovascular health in individuals with spinal cord injuries. Currently, manual stimulation control where stimulation is operated by rowers is mostly utilized. However, it takes time to obtain the skill to initiate FES at the optimal timing. The purpose of this study was to develop a coaching system that helps rowers to initiate FES at the optimal timing. Methods: The optimal range for FES application was identified based on the electromyography of the left quadriceps in 10 able-bodied individuals (AB). Then, the effects of the coaching system on the timing of button-pressing, power, and work were investigated in 7 AB. Results: Vastus lateralis (VL) activation began consistently before the seat reached the anterior-most position. Therefore, seat position at the onset of VL was used as the variable to control the switch timing in the coaching system. The results revealed significantly higher power and work outputs in the coaching than the no-coaching condition (median power coaching: 19.10 W, power no-coaching: 16.48 W, p = 0.031; median work coaching: 109.74 J, work no-coaching: 65.25 J, p = 0.047). Conclusions: The coaching system can provide the optimal timing for FES, resulting in improved performance.