Miracle-dz/UniFAR-FTUs huggingface dataset:
Autoantibodies against voltage-gated potassium channel (VGKC) and glutamic acid decarboxylase (GAD) in psychosis: A systematic review, meta-analysis and case series

decarboxylase case series Abstract Antibodies to the voltage-gated potassium channel (VGKC) complex and glutamic acid decarboxylase (GAD) have been reported in some cases of psychosis. We conducted the first systematic review and meta-analysis to investigate their prevalence in people with psychosis and report a case series of VGKC-complex antibodies in refractory psychosis. Only five studies presenting prevalence rates of VGKC seropositivity in psychosis were identified, in addition to our case series, with an overall prevalence of 1.5% (25/1720) compared to 0.7% in healthy controls (12/1753). Meta-analysis established the pooled prevalence of GAD65 autoantibodies was 5.8%(95%CI:2.0-15.6%;I2=91%;9 studies) in psychotic disorders,with a prevalence of 4.6%(95%CI:1.2-15.9%;9 studies;I2=89%%) and 6.2% (95%CI:1.2-27.0%;2 studies;I2=69%) in schizophrenia and bipolar disorder respectively. People with psychosis were more likely to have GAD65 antibodies than controls (OR 2.24;95%CI:1.28- 3.92%;p=0.005;8 studies;I2=0%). Among 21 participants with treatment-resistant psychosis, none had VGKC antibodies. The prevalence of VGKC antibodies is low in psychosis. Our preliminary meta-analysis suggests GAD autoantibodies are more common in people with psychosis than in controls, although few studies accounted for the possibility of co-existing type 1 diabetes mellitus and the clinical significance of reported GAD titres remains unclear. The paucity of studies reporting thresholds for defining GAD abnormality, and rates of comorbid type 1 DM,preclude interpretations regarding the influence of GAD antibodies on the development of psychotic disorders;and may have led to an overestimate of the prevalence of GAD. Our case series fails to support the hypothesis that VGKC antibodies are linked to treatment resistance in psychosis, but the literature to date is remarkably sparse. Given the aforementioned, we conducted a systematic review and meta-analysis to determine the prevalence of VGKC-complex and GAD antibodies in psychosis. The coprimary outcomes were the prevalence of study-defined VGKC and GAD positivity in psychosis. Secondary outcomes included the comparison of the coprimary outcomes in diagnostic subgroups (e.g. schizophrenia; bipolar disorder) with healthy controls. In addition we aimed to describe the clinical characteristics of patients with VGKC-complex and GAD65 antibody-positive psychotic illness. Within the second stage of this paper, we conducted a retrospective case series to investigate VGKC-complex antibodies in patients with refractory psychosis.
Combined Effects of Deforestation and Doubled Atmospheric CO2 Concentrations on the Climate of Amazonia

Abstract It is generally expected that the Amazon basin will experience at least two major environmental changes during the next few decades and centuries: 1) increasing areas of forest will be converted to pasture and cropland, and 2) concentrations of atmospheric CO2 will continue to rise. In this study, the authors use the National Center for Atmospheric Research GENESIS atmospheric general circulation model, coupled to the Integrated Biosphere Simulator, to determine the combined effects of large-scale deforestation and increased CO2 concentrations (including both physiological and radiative effects) on Amazonian climate. In these simulations, deforestation decreases basin-average precipitation by 0.73 mm day−1 over the basin, as a consequence of the general reduction in vertical motion above the deforested area (although there are some small regions with increased vertical motion). The overall effect of doubled CO2 concentrations in Amazonia is an increase in basin-average precipitation of 0.28 mm da.
Statistical assessment of preferred transitional VGP longitudes based on palaeomagnetic lava data

Summary We examine the statistical significance of a recent report indicating that palaeomagnetic lava data recording reversals and excursions over the past 20 Myr yield transitional virtual geomagnetic poles (VGPs) tending to fall along American and Asian longitudes. Using a bootstrap analysis of spherical densitygrams, we find that this result is neither a sensitive function of nor heavily dependent upon particular transitional records. Previous analyses used χ2 and Kuiper tests of longitudinal uniformity of transitional VGPs. However, the bootstrap analysis presented here takes such statistical tests one step further, showing specifically that American and Asian longitudes are preferred, with significance at about the 95 per cent confidence level. Furthermore, provided the appropriate polarity convention is used, we confirm that Icelandic transitional VGPs tend to fall along Asian longitudes. These results are indicative of non-dipolar transitional fields whose structure is governed by some form of core–mantle coupling.
Iron Age Societies in the Severn-Cotswolds: Developing narratives of social and landscape change

Oxbow says: In this synthesis of archaeological evidence for Iron Age societies in the Severn-Cotswolds, Tom Moore seeks to examine patterns of social organisation and process of social and landscape change from c.800 BC to the mid-late 1st century AD. The chapters look in turn at sites across the landscape, especially through cropmarks, settlements, houses and other structures, burials, and material culture evidence (pottery, querns, salt production, metalwork, coins, agricultural production, glass beads).
Observations of waves' impact on currents in a mixed-energy tidal inlet: Arcachon on the southern French Atlantic coast

ABSTRACT Sénéchal, N. , Sottolichio A. , Bertrand, F. , Goeldner-Giannella, L. , Garlan, T. , 2013. Analysis of currents and storm surge in a mixed-energy tidal inlet during storm conditions. Coastal morphodynamic processes around tidal inlets in mixed-energy environments are particularly complex due to severe tide and wave conditions. Collecting data in this area is generally very challenging. Here we present the first hydrodynamic data collected in the outer inlet of the Arcachon lagoon, a mixed-energy inlet situated on the southern part of the French Atlantic coast. Data consist in vertical current profiles and sea surface elevations collected on the offshore edge of the ebb delta under various tidal and wave conditions. In particular data were collected during the severe Joachim storm associated to wave heights up to 8 m. Preliminary results indicate that current profiles, intensities and direction are very sensitive to wave conditions. Under energetic conditions, the vertical profile of currents become uniform and the longshore drift is enhanced (up to 1.5 m/s). Nevertheless data show that under severe wave conditions (Hm0 > 6.0m) and despite high incidence of waves, the longshore drift is weaker (l< 1 m/s) than under ‘usual' storm conditions associated to Hm0 = 4 – 5m. More surprisingly, directions of the longshore drift are not always consistent with wave incidence under those severe storm conditions and the cross-shore components are very weak while under less energetic conditions we observe intense offshore currents (up to 0.8 m/s).
The dynamical link between surface cyclones, upper‐tropospheric Rossby wave breaking and the life cycle of the Scandinavian blocking

The Scandinavian blocking (SB) is a well‐known quasi‐stationary state of the atmospheric flow and one of the four main weather regimes over the Euro‐Atlantic domain in winter. The aim of our study is to analyze the link between surface cyclones, upper‐tropospheric Rossby wave breakings and the life cycle of SB using ERA‐40 reanalysis. The onset and decay of SB are studied by considering the preferential transitions from the zonal regime to SB and from SB to the Greenland anticyclone regime. During the SB onset, Atlantic cyclones have straight trajectories that extend toward the north of Scandinavia. These surface cyclones are associated with anticyclonic wave breakings in the upper troposphere over Europe. During the SB decay, cyclones are much less present in the eastern part of the Atlantic and most of them present curved trajectories in mid‐Atlantic. They are shown to be linked to cyclonic wave breakings to the south of Greenland.
MOVEMENT RANKING SCALE OF HUMAN BODY STATIC IMAGES FOR SUBJECTIVE TIMING ESTIMATION

Static images representing human bodies with greater suggestion of movement have been estimated as longer than those with lesser movement (Nather & Bueno, 2006a). This study aimed to obtain a reference scale of body movement intensity for static visual stimuli. Stimuli were photographic images of 16 sculptures of dancers made by Edgar Degas. These images were presented to two subject groups (trained and not trained in visual arts and classic ballet) whose task was to judge the intensity of the dancer’s movement using a seven point scale. The data were used to build the Body Movement Ranking Scale (BMRS). Images with equal durations (ordered by BMRS’s arithmetic or geometric progressions) were estimated as having different durations: 1.5- and 3.0-point stimuli were estimated as shorter than 6.0-point ones; 1.5- and 3.0-point were underestimated, and 6.0-point stimuli were overestimated regarding real time; 4.5-point ones were estimated to have the same duration of real time.
Spacial analysis of foreclosure and neighborhood characteristics in Miami metropolitan area, Florida

In 2013, the State of Florida had 13 of the top 20 metropolitan statistical areas (MSA) with the highest foreclosure rate in the country. Despite the high ranking, extensive research on foreclosure has yet to be carried out within the Miami-Fort LauderdalePompano Beach MSA. This research is a foray into an uncharted territory to understand the relationship between foreclosure and neighborhood characteristics in the Miami metropolitan area (MMA) within Miami-Dade County. The study was conducted in two phases: The first phase was to identify the foreclosure pattern in the MMA from 20102013 by implementing the use of spatial analysis such as nearest neighbor analysis, spatial autocorrelation, and cluster and outlier analysis. The statistical analysis used also included correlation analysis, principal component analysis, and regression analysis. The dataset used contained foreclosure count from 2010-2013 and the 2010 census tract level data on neighborhood characteristics such as ethnicity and racial compositions, socioeconomic, demographic, and housing. The spatial and statistical analysis carried out was used to identify the relationship between foreclosure and the neighborhood characteristics. The second phase studied the effect of foreclosure on crime in the city of Miami. Crime data from 2011-2012 was used to study the relationship between crime, foreclosure, and the above mentioned neighborhood characteristics. The statistical analysis carried out in this phase included correlation analysis and regression analysis. Results of the study showed that in MMA, the relationship between foreclosure and other neighborhood characteristics was insignificant. However, the result for the spatial pattern of foreclosure in MMA showed that houses of similar market values were clustered in the northeastern, southeastern and central areas. Additionally, areas dominated by the African American population showed low economic activity and high foreclosure concentration compared to other areas, which could be an influence of subprime lending. Finally, foreclosure alone had no impact on crime whatsoever, but vacancy rate was statistically significant to property crime in the city of Miami. These findings are important in understanding foreclosure distribution and clustering patterns in MMA SPATIAL ANALYSIS OF FORECLOSURE AND NEIGHBORHOOD CHARACTERISTICS IN MIAMI METROPOLITAN AREA, FLORIDA
Seismic anisotropy of serpentinite from Val Malenco, Italy

Serpentinites, deformed in mantle subduction zones, are thought to contribute significantly to seismic anisotropy of the upper mantle and have therefore been of great interest with studies on deformation, preferred orientation, and elastic properties. Here we present a combined study of a classical sample from Val Malenco, Italy, investigating the microstructure and texture with state‐of‐the art synchrotron X‐ray and neutron diffraction methods and measuring ultrasonic velocities both with a multi‐anvil apparatus and a novel instrument to measure 3‐D velocities on spheres. Both, results from diffraction methods and velocity measurements are compared, discussing advantages and disadvantages. From spherical velocities, elastic tensor properties can be derived by inversion. Also from quantitative texture measurements, elastic properties can be modeled by self‐consistent averaging. Good agreement between the velocity and microstructural models is observed.
Cretaceous oceanic anoxic events: causes and consequences

Organic carbon-rich sediments are globally developed in pelagic sedimentary sequences of Aptian-Albian and Cenomanian-Turonian age. They formed in a variety of paleo-bathymetric settings including oceanic plateaus and basins, continental margins and shelf seas. The widespread nature of these deposits suggests that they were not strictly controlled by local basin geometry but were a product of ″Oceanic Anoxic Events″ . Interpretation of these events as the result of the interplay of two major geologic and climatic factors is given. The Late Cretaceous transgression which increased the area and volume of shallow epicontinental and marginal seas and was accompanied by an increase in the production of organic carbon; and the existence of an equable global climate which reduced the supply of cold oxygenated bottom water to the world ocean. This combination of climatic and hypsographic conditions favoured the formation of an expanded oxygen-minimum layer and where this intersected the sediment-water interface, organic carbon-rich deposits could be formed, these being records of ″Oceanic Anoxic Events″ .
Levomepromazine and Weaning from Sedation in Traumatic Brain Injured Patients

Background: Sedation is a key for the management of patients with traumatic brain injuries. However, in some of the brain injured patients, weaning from sedation is a real challenge. In this work, we aim to evaluate the use of Levomepromazine as a safe strategy for weaning from sedation in mechanically ventilated brain injured patients. Patients and Method: This is a prospective randomized controlled monocentric study carried out on patients admitted to the surgical ICU of the university hospital Ibn Rochd of Casablanca, between January 2022 and April 2022. The study included all mechanically ventilated patients over 18 years old admitted for traumatic brain injury. The patients were divided in two groups. The primary endpoint assessed was the need to resume sedation. Results: In our study, the average age was 30 years ± 10.9. 97% were men. Resumption of sedation was 73.3% in the control group compared to only 37,5% in the group who took levomepromazine. Agitation was significantly lower in the levomepromazine group 18.7% compared to 73,3% in the control group. The reasons of re-sedation in both groups were accidental extubation due to the agitation of the patient and also patient-ventilator asynchrony. The length of stay was reduced in the control group with 18,4 days versus 28,7 days in the levomepromazine group. Concerning the impact on ICU deaths, there was no significant difference. Conclusion: Levomepromazine has been shown through this work to reduce agitation in traumatic brain injured patients. ICU Death may not be influenced by the use of this molecule but it would reduce the need for prolonged or re-sedation.
Toroidal-shaped interplanetary disturbance associated with the halo coronal mass ejection event on 14 July 2000

[1] Interplanetary scintillation (IPS) measurements made with the 327 MHz radio telescopes of the Solar–Terrestrial Environment Laboratory, Nagoya University, have been used to study a three-dimensional structure of the interplanetary (IP) disturbance associated with the halo coronal mass ejection (CME) event on 14 July 2000 (the so-called “Bastille Day event”). The IPS observations indicated that the Bastille Day IP disturbance was between 0.3 and 0.7 AU at 17 ± 3 hours after the flare occurrence. A model fitting analysis has been applied here to the IPS observations to reconstruct a global structure of the Bastille Day IP disturbance. As a result, the IP disturbance is found to form a loop-shaped structure that is significantly longer in the longitudinal (east–west) direction than in latitude. This toroidal-shaped IP disturbance is found to cross the large-scale magnetic neutral line almost perpendicularly at its center. Our IPS data also show a nonuniform expansion of the IP disturbance, and the fastest direction is found to lie near above the flare site. Using the best-fit model determined here and information on the ambient solar wind density from in situ measurements, the mass contained by the IP disturbance has been estimated to be ∼ 5.3 × 1016 g. The result obtained from the present analysis is consistent with independent observations that suggest the Bastille Day interplanetary CME has decelerated significantly in the solar wind. The radial evolution of the apparent feature of the IP disturbance has been revealed from a model calculation using the best-fit parameters, and this evolution is consistent with IPS measurements made at Ooty, India, slightly later in time. While an origin of the toroidal-shaped disturbance is an open question, the compressed plasma between the coronal ejecta and the ambient solar wind or the ejecta itself are considered as a possible one.
Effect of plant dynamic processes on African vegetation responses to climate change: Analysis using the spatially explicit individual‐based dynamic global vegetation model (SEIB‐DGVM)

[1] We applied a dynamic global vegetation model (DGVM) to the African continent. After calibration, the model reproduced geographical distributions of the continent's biomes, annual gross primary productivity (GPP), and biomass under current climatic conditions. The model is driven by the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emission Scenarios (SRES) A1B scenario of rising CO2, and by climate changes during the twenty-first century resulting from the change in CO2concentrations, simulated by a coupled Model for Interdisciplinary Research on Climate (MIROC) ocean atmosphere model. Simulations under this condition revealed time lags between environmental change and biome change, with the extent of these lags depending largely on the type of biome change. A switch in forest type was accompanied by the longest delay in biome change among all changes classified, indicating that resident trees largely prevent the establishment of nonresident tree types adapted to the new environment, and that tree growth requires additional years after successful establishment. In addition, assumptions for tree dispersal, which determine whether nonresident tree types can be established, modified the patterns of biome change under the twenty-first-century environment: under the assumption that nonresident tree types cannot be established even if environmental conditions change, the extent of the forest type switch and the development of forest and savanna were suppressed, while forest dieback was enhanced. These changes accompanied a slowing of the increasing trend in net primary productivity (NPP), biomass, and soil carbon during the twenty-first century and in subsequent years. These results quantitatively demonstrate that both patch dynamics and invasive tree recruitment significantly modify the transient change in vegetation distribution and function under a changing environment on the African continent.
Relationship of Reef Fish Assemblages and Topographic Complexity on Southeastern Florida Coral Reef Habitats

Abstract Reef fish assemblage relationships with in situ and lidar topographic measurements across the seascape were analyzed to evaluate the possibility of using lidar metrics as a proxy for prediction models. In situ topographic complexity (i.e., linear rugosity) was measured from 346 point-count fish surveys spanning the reef seascape. Lidar topographic measurements (i.e., surface rugosity, elevation, and volume) were obtained from a high-resolution lidar bathymetric dataset of each survey's footprint. The survey sites were characterized by an independently derived benthic habitat map. Reef fish abundance and species richness appeared to increase with increasing topographic complexity. Although significant, the relationship was weak. Habitat characterization showed that these relationships changed across the seascape. The relationship between topographic complexity and species richness was more pronounced in shallow habitats, whereas, topographic complexity related more closely to abundance in offshore habitats. In situ rugosity measurement yielded the best explanation of fish assemblage structure parameters, but the weaker lidar metric correlations followed similar trends. Accordingly, lidar-measured topographic complexity may be a useful metric for reef fish distributional models. Such predictive models could have many scientific and management applications including: estimating fish stocks, viewing data trends across the seascape, and designing marine protected areas. However, better understanding of the appropriate spatial scale, measurement scale, and fish operational scale is needed, as well as more research on the dynamics of how reef fishes relate to topographic complexity and other ecological factors influencing distributions across the seascape.
Aspect influences on soil water retention and storage

Many catchment hydrologic and ecologic processes are impacted by the storage capacity of soil water, which is dictated by the profile thickness and water retention properties of soil. Soil water retention properties are primarily controlled by soil texture, which in turn varies spatially in response to microclimate‐induced differences in insolation, wetness and temperature. All of these variables can be strongly differentiated by slope aspect. In this study, we compare quantitative measures of soil water retention capacity for two opposing slopes in a semi‐arid catchment in southwest Idaho, USA. Undisturbed soil cores from north and south aspects were subjected to a progressive drainage experiment to estimate the soil water retention curve for each sample location. The relatively large sample size (35) supported statistical analysis of slope scale differences in soil water retention between opposing aspects. Soils on the north aspect retain as much as 25% more water at any given soil water pressure than samples from the south aspect slope. Soil porosity, soil organic matter and silt content were all greater on the north aspect, and each contributed to greater soil water retention. These results, along with the observation that soils on north aspect slopes tend to be deeper, indicate that north aspect slopes can store more water from the wet winter months into the dry summer in this region, an observation with potential implications on ecological function and landscape evolution. Copyright © 2011 John Wiley & Sons, Ltd.