Miracle-dz/UniFAR-FTUs huggingface dataset:
RMHP_A_329387 4595..4607

1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria; 2Department of Clinical Pharmacy and Practice, College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 3Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; 4Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, Lagos State University, Ikeja, Lagos, Nigeria; 5Department of Anaesthesia and Intensive Care Unit, Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria; 6Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria; 7Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos, IdiAraba, Lagos, Nigeria; 8Pharmaplus Nigeria Limited, Kano, Nigeria; 9Directorate of Education and Training, Pharmacists Council of Nigeria, Idu, Abuja, Nigeria; 10Department of Pharmacy, Lagos Island Maternity Hospital, Lagos, Nigeria Purpose: Community pharmacists (CPs) frequently attend to pediatric patients with pain but limited data exist regarding their knowledge of and attitude to effective management of pediatric pain in Nigeria. Thus, this study aimed to evaluate the knowledge of and attitude to pediatric pain management among CPs in Nigeria. Patients and Methods: A validated and pilot-tested questionnaire, the Community Pharmacists Survey on Pediatric Pain, was administered to 517 eligible participants at the 38th Annual National Conference of the Association of Community Pharmacists of Nigeria. Independent samples t-test and one-way analysis of variance were used for inferential statistical analyses. Results: CPs with additional higher academic qualifications and clinically related additional academic degrees had significantly higher mean knowledge scores relative to first degree only holder counterpart (t= 4.33, p< 0.05, Eta=0.05) and those without clinically related second degrees (t= 6.34, p< 0.05, Eta=0.27). Pain knowledge among the study cohort also varied significantly by age group, years of practicing community pharmacy, ownership structure of premises, geographical location of practice and previous exposure to pain management training (F(4370)=2.858, p=0.025, Eta=0.03; F(3371)=3.985, p=0.008, Eta=0.03; F(2372)=3.643, p=0.027, Eta=0.02; F(5369) =4.497, p=0.01, Eta=0.06; F(2372)=3.587, p=0.029, Eta=0.02), respectively. Conclusion: Community pharmacists’ knowledge of and attitude to pediatric pain management in Nigeria appeared sub-optimal, and requires regular targeted educational intervention to fill the identified gaps, improve service delivery and patient outcomes.
Review of Traditional and Non-Traditional Medicinal Genetic Resources in the USDA, ARS, PGRCU Collection Evaluated for Flavonoid Concentrations and Anthocyanin Indexes

Non-traditional medicinal species include velvetleaf (Abutilon theophrasti Medik.), Desmodium, Termanus labialis (L.f.) Spreng. and the traditional roselle (Hibiscus sabdariffa L.). Flavonoids and anthocyanins have been shown to have anti-cancer activities in humans. Fruit and leaves from velvetleaf, seeds from D. discolor Vogel, D. incanum (G. Mey) D.C., D. intortum (Mill.) Urb. , D. E. Mey. , D. tortuosum (Sw.) D.C., T. labialis, and calyces from roselle accessions in the USDA, ARS, PGRCU collection could be sources of myricetin, quercetin, kaempferol, isorhamnetin, luteolin, apigenin, and anthocyanins. The objectives of this review article are to report medicinal plant progress for flavonoid and anthocyanin index variability among these species which can be used to develop superior cultivars for use as nutraceuticals, functional foods, and phytopharmaceuticals.
A Soybean Transcript Map: Gene Distribution, Haplotype and SNP Analysis

1 Soybean Genomics and Improvement Laboratory, USDA, ARS, Beltsville, MD USA 20705; 2 Current address: NICEM, CALS, Seoul National University, San 56-1, Sillim-9-dong, Gwanak-gu, Seoul, 151-921 South Korea 3 Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, MD 20705 USA; 4 Dep. of Natural Resources and Landscape Architecture, Univ. of Maryland, College Park, MD 20742 USA; 5 Dep. of Agronomy, Univ. of Nebraska, Lincoln, NE USA 68583-0915 USA; 6 Dep. of Biology, Univ. of Utah, Salt Lake City, UT 84112 USA; 7 Monsanto Co., 800 Lindbergh Blvd. St. Louis, MO 63167; 8 Genetic Resources Division, National Institute of Agricultural Biotechnology, Rural Development
Examining the relationship between cyclist route choice, weather, and urban design

Over the last decades, climate change has become one of the most discussed topics within the transport sector (Böcker, 2014). With the increasing awareness of the need to switch to more environmental-friendly transportation modes, travel behavior of cyclists is being researched more intensively and in relation to a wider scale of influencing factors (Heinen et al., 2010). Within the Netherlands, cycling is historically a widely used transportation mode within urban areas. However, with the emergence of the electrical bikes, inter-city transportation can more easily be conducted by bicycle as well. To stimulate the use of bicycles and electrical bicycles as a substitute for less sustainable transportation modes, the Province of Noord-Brabant is developing ‘fast bike lanes’ through and between the larger cities in the province (Provincie Noord-Brabant, 2009). These connections between the larger cities in Noord-Brabant should enable fast traveling between these cities, potentially providing the opportunity to use bicycles and electrical bicycles for longer distance travelling. As these will be significant investments for the province, the bicycle lanes should be designed in such a way that they meet the demands of potential users. Therefore, research on preferences of cyclists is highly relevant for the province. Over the last decades, a rapidly growing number of studies have been researching the influence of urban design on cyclist route choice, sometimes resulting in conflicting findings (Handy et al., 2010; Moudon et al., 2005). However, it indicates the importance of expanding the knowledge on the relationship between urban configuration and cyclist route choice. This requires continuation on existing studies, development and quantification of new spatial factors, and inclusion of other environmental factors that can be related to urban design.
RESEARCH ON WATER ACTIVITY INDEX IN FROZEN MEAT FOODS

The article deals with a science intensive technology of fast-frozen dishes production with the use of activated liquids and systems. The objective of this research is to investigate the measurement of water activity in the developed frozen meat products. A receipt of fast-frozen dishes includes sausage goods and a vegetable garnish. The sausage goods are made of beef, pork, dried milk, starch, protein-fat emulsion and gel based on the «Kat-gel 95» protein preparation. The water used is treated in the apparatus of «Izumrud» type, obtaining acid and alkaline fractions with a specified level of pH. Their further activation is done using a commercial sound processor «Hielscher Ultrasound Technology UP». Activated liquids obtained have pronounced bactericidal and antiseptic qualities, thus promoting prolonged shelf life of finished goods. The research is done using the analytic and organoleptic methods, the method of measurement, the method of calculation and the expert one. To determine the water activity index we use samples defrosted after thirty days of storing. The values of water activity indices are determined separately for fast-frozen dishes produced with the use of activated liquid systems and for control samples produced with the use of tap potable water. According to the results of the water activity index determination it has been established that the samples produced with the use of activated liquids and systems have the index of 0.9638. The water activity index of the control samples appears to be higher by 0.0198 units in comparison with the samples produced with the use of activated liquids. This fact indicates that water has a stronger connection with non-aqueous components during activation of aqueous systems when producing foods. Consequently, water has a lower possibility to support processes leading to goods spoilage.
PESA INTERNATIONAL JOURNAL OF SOCIAL STUDIES EVALUATION OF AN ENGLISH COURSEBOOK IN TURKEY BASED UPON SOCIOLINGUISTIC ASPECTS

In this day and age, learning English has become quite popular all over the world as it has been accepted to be used as a lingua franca after the World War II (Christiansen, 2015). Being the lingua franca of the world, the teaching of the language has become a controversial issue. Accordingly, what should be taken into consideration in the teaching process has been studied. In the present study, the design of which is qualitative, a checklist (Atar & Erdem, in press) formed via the implications of sociolinguistics were used as a basis, and an English coursebook that is used by eleventh graders in state high schools in Turkey for foreign language education and provided by the Ministry of National Education freely, was evaluated in terms of English language teaching. As a result of the evaluation process, it was revealed that the coursebook has deficiencies, considering the criteria in the checklist. In light of that result, various suggestions have been made so that the coursebook can be improved in terms of sociolinguistic
TESS first look at evolved compact pulsators: Known ZZ Ceti stars of the southern ecliptic hemisphere as seen by TESS

Context. We present our findings on 18 formerly known ZZ Ceti stars observed by the TESS space telescope in 120s cadence mode during the survey observation of the southern ecliptic hemisphere. Aims. We focus on the frequency analysis of the space-based observations, comparing the results with the findings of the previous ground-based measurements. The frequencies detected by the TESS observations can serve as inputs for future asteroseismic analyses. Methods. We performed standard pre-whitening of the data sets to derive the possible pulsation frequencies of the different targets. In some cases, we fitted Lorentzians to the frequency groups that emerged as the results of short-term amplitude/phase variations that occurred during the TESS observations. Results. We detected more than 40 pulsation frequencies in seven ZZ Ceti stars observed in the 120s cadence by TESS, with better than 0.1 microHz precision. We found that HE 0532-5605 may be a new outbursting ZZ Ceti. Ten targets do not show any significant pulsation frequencies in their Fourier transforms, due to a combination of their intrinsic faintness and/or crowding on the large TESS pixels. We also detected possible amplitude/phase variations during the TESS observations in some cases. Such behaviour in these targets was not previously identified from ground-based observations.
Ecological morphology of lacustrine threespine stickleback Gasterosteus aculeatus L. (Gasterosteidae) body shape

Threespine sticklebacks, small fish with a circumglobal distribution in coastal marine and freshwater of the northern hemisphere, present a remarkable scope of variation in body and fin shape among populations. The repeated evolution of divergent body shapes in a radiation of stickleback from Cook Inlet, Alaska suggests that diversification has proceeded by extensive parallel selection. To explore this hypothesis, hydromechanical equations of fish propulsion and descriptions of stickleback foraging and anti-predator behaviours were used to develop a series of hypotheses that predicted the evolutionary effects of native predatory fishes (NPF) and relative littoral area (RLA) on body shape. Body shape was measured using Cartesian coordinates of anatomical landmarks transformed by the generalized resistant fit superimposition. In general, the results were consistent with the hypotheses that (1) RLA has a direct effect on selection for foraging behaviour and morphology, (2) RLA has an indirect effect on selection for morphology employed in predator evasion, (3) presence of NPF has a direct effect on selection for evasive morphology, and (4) presence of NPF has an indirect effect on selection for foraging behaviour and morphology. The magnitude of the divergence of body shapes present in the Cook Inlet system suggests that extreme phenotypes have evolved by opportunistic expansion into new habitat relatively free of interspecific competition.
Interactive comment on “Sampling Error in Aircraft Flux Measurements Based on a High-Resolution Large Eddy Simulation of the Marine Boundary Layer”

In this study, the author uses an output from a Large-Eddy Simulation performed with a high-resolution, which explicitly resolved the major part of the turbulent structures. The domain-averaged turbulent ﬂuxes can thus be considered as the "truth". This reference is then used to explore, with virtual track traversing the LES domain, the capacity of aircraft ﬂux measurements to properly estimate the turbulent ﬂuxes, the associated sampling problem and random errors. The results, compared with previous work on the topic (Lenschow and Stankov (1986), Lenschow et al., (1994)), lead to similar conclusions about the required length of the tracks to limit the sampling errors.
Is it faster and is that Measurable A Quantitative Research Into the Time Effects of Integrated Contract Forms in Development Processes

Integrated contract forms are seen as a solution to various problems in the construction industry. Some studies found that building projects delivered with integrated contract forms show better performances on time, cost and quality. Other studies state that projects developed with integrated contract forms do not perform better on time, cost or quality when compared to projects developed with traditional contract forms. Conclusions from the studies analyzed vary and these studies have their shortcomings. This study reflects critically on these previous studies in order to promote better research and to reveal a small piece of the puzzle called ‘integrated contract forms’. Empirical findings from a case control study of thirty secondary schools indicate that the use of integrated contract forms do not provide the expected benefits to time performance when compared to traditional contract forms. The data was collected from project managers via online questionnaires. However, when there is above average time pressure during the development process, parties tend to choose for integrated contracts because they assume that projects developed in this way have faster processes than projects developed with traditional contracts.
OAEM_A_166086 77..86

Department of Emergency Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand Abstract: Sepsis is a common presentation in the emergency department and a common cause of intensive care unit admissions and death. Accurate triage, rapid recognition, early resuscitation, early antibiotics, and eradication of the source of infection are the key components in delivering quality sepsis care. Evaluation of the patient’s volume status, optimal hemodynamic resuscitation, and evaluation of patient response is crucial for sepsis management in the emergency department.
Dendritic Spine Modifications in Synaptic Plasticity

Synaptic plasticity is regarded as the cellular mechanism underlying the refinement of neural connections during development and learning/memory functions in adults. Alterations in dendritic spine morphology (elongation or shrinkage) and/or spine density occur with synaptic plasticity. This structural modification has been proposed to enable persistent, long-term change in synapses. Here we review spine modifications associated with synaptic plasticity and discuss their contributions to synaptic plasticity and brain diseases.
Hydrogen Sulfide Inhibits TMPRSS 2 in Human Airway Epithelial Cells : Implications for SARS ‐ CoV ‐ 2 Infection

The COVID‐19 pandemic has now affected around 190 million people worldwide, accounting for more than 4 million confirmed deaths. Besides ongoing global vaccination, finding protective and therapeutic strategies is an urgent clinical need. SARS‐CoV‐2 mostly infects the host organism via the respiratory system, requiring angiotensin‐converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) to enter target cells. Therefore, these surface proteins are considered potential druggable targets. Hydrogen sulfide (H2S) is a gasotransmitter produced by several cell types and is also part of natural compounds, such as sulfurous waters that are often inhaled as low‐intensity therapy and prevention in different respiratory conditions. H2S is a potent biological mediator, with anti‐oxidant, anti‐inflammatory, and, as more recently shown, also anti‐ viral activities. Considering that respiratory epithelial cells can be directly exposed to H2S by inhalation, here we tested the in vitro effects of H2S‐donors on TMPRSS2 and ACE2 expression in human upper and lower airway epithelial cells. We showed that H2S significantly reduces the expression of TMPRSS2 without modifying ACE2 expression both in respiratory cell lines and primary human upper and lower airway epithelial cells. Results suggest that inhalational exposure of respiratory epithelial cells to natural H2S sources may hinder SARS‐CoV‐2 entry into airway epithelial cells and, consequently, potentially prevent the virus from spreading into the lower respiratory tract and the lung.
Primum Non Nocere

27.1%; p < 0.0001, respectively). Serum C-reactive protein levels were also significantly higher in the bypass group (median 22.0 mg/l vs. 7.0 mg/l; p < 0.0001). During the follow-up period, 61 major amputations (10.6%) and 171 deaths (30.2%) occurred. The cumulative incidence rate of amputation or death at 5 and 8 years were 48.6% and 52.9% in the bypass group, and 52.9% and 64.2% in the EVT group, respectively (p 1⁄4 0.30) (Figure 1A). The propensity score-adjusted hazard ratio was 1.14 (95% confidence interval 0.83 to 1.58; p 1⁄4 0.41). The cumulative incidence rate of mortality at 5 and 8 years were also 39.4% and 45.9% in the bypass group, and 49.1% and 61.4% in the EVT group, respectively (p 1⁄4 0.64) (Figure 1B). The incidence rate of revascularization was lower in the bypass group than in the EVT group (18.1% vs. 47.7% at 5 years and 21.5% vs. 51.7% at 8 years; p < 0.0001). In the study, the rates of amputation-free survival were broadly comparable between the 2 procedure groups in HD patients although bypass surgery had lower rates of any revascularization compared with EVT. These results were mostly similar to finding in general population previously reported (3). However, the 2 procedures were assigned in a nonrandomized manner in the present study, and there might be too many chances for bias in the data assignments. Hence, we conducted propensity score adjustment to minimize the characteristics differences, but theremay still be residual confounding, especially in that the definition of CLI might potentially be misclassified because we only referenced Fontaine classification on the chart review. In addition, these results may only be generalizable in Japanese HD patients because they reportedly have a better prognosis, compared with those in the United States and Europe (5). Further validation and replication is needed.
FAMILIALITY OF GENDER NONCONFORMITY 1 Familiality of Gender Nonconformity Among Homosexual Men Abstract Gender nonconformity–both in childhood and in adulthood–is a strong correlate of male sexual orientation, with homosexual men

Gender nonconformity–both in childhood and in adulthood–is a strong correlate of male sexual orientation, with homosexual men showing greater gender nonconformity during both periods. Gender nonconformity also tends to be markedly variable, with some homosexual men being more feminine, or less masculine, than others. We replicated large differences in self-reported childhood and adult gender nonconformity between homosexual and heterosexual men. Subsequently, we examined the extent to which homosexual men’s variation in gender nonconformity runs in families by examining pairs of genetic brothers who were either both homosexual (concordant pairs) or had different sexual orientations (discordant pairs). Both concordant and discordant pairs yielded modest positive correlations consistent with moderate genetic and/or familial environmental effects on gender nonconformity. Our results support the feasibility of supplementing genetic studies of male sexual orientation with analyses of gender nonconformity variation.
Inappropriate Dental Antibiotic Prescriptions: Potential Driver of the Antimicrobial Resistance in Albaha Region, Saudi Arabia

Purpose: The aim of this study was to analyze and evaluate dental antibiotic prescriptions in Albaha Region, Saudi Arabia. Patients and Methods: A two-year retrospective cohort study was conducted between September 1, 2017 and September 1, 2019 in children and adults. Data collected from the patients ’ medical records were analyzed using SPSS. The Z-test with Bonferroni correction and descriptive proportions were utilized to compare several levels of categorical variables. Results: Of the 43,255 dental visits, antibiotics were provided during 12,573 (29.1%). The commonly prescribed antibiotics were amoxicillin and amoxicillin combined with metronidazole (56.3% and 16.9%, respectively). Alarmingly, antibiotics were provided in several conditions for which they are medically neither recommended nor indicated; together, they represented 27.8% of those consultations in which antibiotics were prescribed. Female dentists prescribed more antibiotics than male dentists (30%, P = < 0.000), with male patients receiving more antibiotics than female patients (36%, P = <0.0001). Conclusion: Unnecessaryprescriptionofantibioticswasobservedinthepresentstudy.Improving knowledge and awareness of Saudi dentists on dental antibiotic prescription is warranted.