Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeting the intrinsically disordered architectural High Mobility Group A (HMGA) oncoproteins in breast cancer: learning from the past to design future strategies

ABSTRACT Introduction Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat because of its heterogeneity and lack of specific therapeutic targets. High Mobility Group A (HMGA) proteins are chromatin architectural factors that have multiple oncogenic functions in breast cancer, and they represent promising molecular therapeutic targets for this disease. Areas covered We offer an overview of the strategies that have been exploited to counteract HMGA oncoprotein activities at the transcriptional and post-transcriptional levels. We also present the possibility of targeting cancer-associated factors that lie downstream of HMGA proteins and discuss the contribution of HMGA proteins to chemoresistance. Expert opinion Different strategies have been exploited to counteract HMGA protein activities; these involve interfering with their nucleic acid binding properties and the blocking of HMGA expression. Some approaches have provided promising results. However, some unique characteristics of the HMGA proteins have not been exploited; these include their extensive protein-protein interaction network and their intrinsically disordered status that present the possibility that HMGA proteins could be involved in the formation of proteinaceous membrane-less organelles (PMLO) by liquid-liquid phase separation. These unexplored characteristics could open new pharmacological avenues to counteract the oncogenic contributions of HMGA proteins.
Analysis of RF Inductive Effect in S-Parameters of Body Contact PD-SOI MOSFETs

The anomalous RF inductive effect in which <inline-formula> <tex-math notation="LaTeX">${S}_{{21}}$ </tex-math></inline-formula>- and <inline-formula> <tex-math notation="LaTeX">${S}_{{22}}$ </tex-math></inline-formula>-parameters rotate clockwise in the lower and upper half-circles, respectively, with increasing the frequency at the high <inline-formula> <tex-math notation="LaTeX">${V}_{\text {DS}}$ </tex-math></inline-formula> region has been investigated in body contact (BCT) high-resistivity (HR) partially depleted (PD) silicon-on-insulator (SOI) nMOSFETs with a very high aspect ratio of gate finger. The negative output capacitance generated from a substrate current-induced body effect (SCBE) is physically identified for the first time as the origin of the RF inductive effect by deriving the output admittance equation of a body transconductance source in RF equivalent circuit model considering SCBE. The bias-dependent frequency effect that the drain–source conductance and negative capacitance converted from measured <inline-formula> <tex-math notation="LaTeX">${S}$ </tex-math></inline-formula>-parameters are largely reduced by higher pole frequency with increasing <inline-formula> <tex-math notation="LaTeX">${V}_{\text {DS}}$ </tex-math></inline-formula> is clearly explained by admittance equations derived from the SCBE output equivalent circuit. The bias-dependencies of inductive effect parameters related to SCBE are accurately extracted using small-signal equivalent circuit modeling of BCT PD-SOI nMOSFETs. Based on this result, the bias-dependence of <inline-formula> <tex-math notation="LaTeX">${S}_{{21}}$ </tex-math></inline-formula>- and <inline-formula> <tex-math notation="LaTeX">${S}_{{22}}$ </tex-math></inline-formula>-parameters is analyzed in detail.
Cytotoxic potential of the Red Sea sponge Amphimedon sp. supported by in silico modelling and dereplication analysis

Abstract The chemical profile of the butanol fraction of the Red Sea sponge Amphimedon sp. was explored using liquid chromatography coupled with high-resolution mass spectrometry and identified compounds (1–11). Moreover, cytotoxic activities of the total extract and other fractions were examined against three cell lines HEPG2, MCF7 and CACO2, revealed the powerful effect of the total extract and the butanol fraction against the three cell lines. Further chromatographic separation of the active butanol fraction yielded the isolation of three known compounds (9–11). Molecular modelling was carried out with the active site of the SET protein. Docking study results revealed that amphiceramides A-B (7–8) and acetamidoglucosyl ceramide (6) showed the highest energy binding affinities and interaction in the binding site of SET protein. Additionally, ADME/Tox calculations were performed for the compounds to predict their pharmacokinetics profile. These results highlighted the valuable chemical entities of Amphimedon sp. as lead source for cytotoxic natural products. Graphical Abstract
Same-Day Correlates and Prior-Day Predictors of Couples’ Violent Behaviors Based upon Partners’ Daily Reports

Although previous research identified predictors of violent events within violent heterosexual couples, findings were limited to the woman’s reports, to her perceptions; his assessments were not obtained. This exploratory study was conducted to gain understanding of proximal predictors of violence assessed in “real-time” from the perspective of both partners. Fifteen adult heterosexual couples in which the woman reported experiencing partner violence in the prior 30 days were enrolled in a primary care clinic. Each partner provided separate daily telephone reports for eight weeks via an automated Interactive Voice Response (IVR), concerning the previous day’s violence, alcohol use, stressors, emotional reactions and concerns for children. Same-day correlates were determined by Pearson correlations while prior-day predictors were identified via vector autoregression. Same-day correlations show that men’s violence was associated with almost every other variable while women’s violence correlated with men’s violence, men’s drug use, women’s alcohol use, anger, closeness, hassles, and all men’s negative feelings. Using prior-day predictors, men’s violence was related to feelings (primarily hers), but women’s violence was more dependent upon feelings of both of them as well as women’s prior-day violence and alcohol use. Men’s violence was dependent upon their partners’ prior-day feelings and the men’s lack of concern about effects of violence on children. Women’s violence was also dependent upon women’s prior-day feelings, as well as women’s violence, alcohol use, marital closeness, and men’s concern for children. Although the co-occurrence of men’s and women’s violence has been seen before, in this study only women’s violence was linked to alcohol use.
In vivo studies of respiratory physiology in Arctic charr (Salvelinus alpinus) and Atlantic cod (Gadus morhua) exposed to aquaculture relevant levels of hypoxia, hyperoxia and hypercapnia

Free-swimming Atlantic cod (Gadus morhua) were exposed to water oxygen pressures (PwO2) ranging from 18.1 to 41.5 kPa and sampled for blood using an indwelling caudal artery cannula. Arterial blood oxygen pressure (PaO2) increased with increasing PwO2, from 12.0 kPa in normoxia (18.1 kPa) to 34.2 kPa in the highest hyperoxic level tested (41.5 kPa). Blood CO2 pressure and plasma bicarbonate concentration increased with PwO2, indicating reduced ventilation with increased PwO2. Plasma glucose, sodium and potassium were not affected by water oxygen level. Blood oxidative stress biomarkers, reduced glutathione, oxidized glutathione and the oxidative stress index (ratio between oxidized and total glutathione) differed intermittently between normoxia and hyperoxia. The oxidative stress index was higher in the blood of exposed compared to unexposed control cod. Together with elevated PaO2, these findings suggest increased production of reactive oxygen species and increased oxidative stress in Atlantic cod exposed to hyperoxia.
Analysis of heat dissipation characteristics of three-dimensional graphene-carbon nanotube composite structures

With the rapid development of electronic materials and technologies, the working frequencies of electronic components and devices have been greatly improved and the volume of electronic products has been shrinking. The integration density has increased significantly, which puts forward higher requirements for thermal management. One of the keys to the heat dissipation of electronic components is to transfer the heat rapidly to the radiator through the heat conducting medium. Therefore, the development of high conductive materials has become a research hotspot of high-density integrated devices and systems. Due to their excellent heat transfer properties, carbon nanomaterials such as carbon nanotube and graphene have attracted extensive attention. The thermal conductivities of carbon nanotube and graphene have obvious anisotropy, which limited their applications to some extent. In this paper, three-dimensional composite structures composed of graphene sheets and carbon nanotubes are considered. The heat transfer processes are simulated by molecular dynamics method and the heat transfer characteristics of van der Waals interaction and chemical bond structures are analyzed. The effects of heat flow and nanotube layout on the thermal properties of three-dimensional composite structures are discussed.
Biomechanical markers of impaired motor coordination

This study is devoted to movement analysis from a biomechanical perspective to evaluate coordination lesions. It aims to find the most characteristic biomechanical markers that would help to quantitatively evaluate impaired motor coordination without performing or supplementing clinical tests. A total of 54 (31 – multiple sclerosis (MS) and 23 – healthy (CO)) subjects performed the heel-to-shin test (HST) and correspondingly, kinematic parameters of lower extremity were measured by using six 9DOF wireless inertial sensors (IMUs). Three-dimensional data from IMUs was processed utilizing Madgwick's Attitude and Heading Reference Systems (AHRS) algorithm. MS group was compared to CO, as well as impaired body side with an intact among MS subjects. Obtained results revealed following meaningful parameters for coordination between MS and CO ($p \lt 0.01)$: motion time, range of motion (ROMs) of the ankle, knee in the sagittal plane; hip in frontal plane; variability and SD variation. Following biomechanical indices, namely ROMs of the ankle, knee in the sagittal plane; hip in frontal plane; hip in transverse plane, were used for the evaluation of MS body sides’ ($p \lt 0.01$). Latter biomechanical markers clearly describe impaired motor coordination and enables distinguishing from the sound. New information precisely explain movement quality and it is useful for the assessment of the impairment.
The COVID-19 Crisis in Sub-Saharan Africa: Knowledge, Attitudes, and Practices of the Nigerian Public

Abstract. Within a short period of time, COVID-19 has spread globally, wreaking havoc in various facets of life. This study sought to measure the level of COVID-19 knowledge, attitudes, and practices of the Nigerian public. This was a cross-sectional online survey of the general population of educated Nigerians who had Internet access. Sociodemographic data and participants’ knowledge, attitudes, and practices relating to COVID-19 were collected. Scores assessing knowledge, attitudes, and practices were allocated and graded based on specific stratified demarcations. Student’s t-test, analysis of variance, and logistic regression analysis were used where appropriate. Of the total 1,015 respondents, most of them exhibited good knowledge of COVID-19, with a mean knowledge grade of 78%; this significantly affected their attitude and practice grades (66% and 60.4%, respectively). Most respondents expressed positive attitudes toward foreigners and other stigma-prone groups, while also practicing appropriate preventive measures. Those aged 21–30 years and those with medical-related occupations had significantly higher knowledge scores (P < 0.001); and having a medical-related occupation increased the likelihood of having good knowledge compared with being unemployed (odds ratio [95% CI]: 6.6 [2.5–17.3]). Male participants aged 21–30 years and those with medical-related occupations had significantly higher attitude scores (P < 0.05). Engaging literate Nigerians on various media platforms, particularly social media, will result in wider reach for the purpose of COVID-19 education. Further studies on other sociodemographic groups within the country (e.g., the less educated) would give a clearer picture of the Nigerian situation as regards COVID-19 knowledge, attitudes, and practices (coronavirus, COVID-19, Public health, Nigeria, Africa).
Transformation of Aggregatibacter actinomycetemcomitans with Green Fluorescent Protein

Green fluorescent protein (GFP) is one of the most useful biological markers for monitoring gene expression and the localization of particular cells. We constructed a GFPexpressing Aggregatibacter actinomycetemcomitans transformant by transposon insertion. This anaerobic, oral, gram-negative bacterium is thought to be the major causative agent in localized aggressive periodontitis and possesses the gene coding for leukotoxin(ltx). As this gene is stably expressed, the region extending from the ltx promoter to the initiation codon was amplified using PCR and temporarily cloned into a small Escherichia coli plasmid, pResKm. The DNA fragment containing the GFP gene(gfp)ORF was excised from the commercially available plasmid pAcGFP1-C1, purified by gel electrophoresis, and inserted downstream of the ltx initiation codon in the correct reading frame. This gene fusion was further cloned into the NotI site of the commercially available shuttle plasmid, pUTminiTn5, which contains the gene coding for the transposase, and then introduced into the chromosome of A. actinomycetemcomitans strain HK1651 by electroporation. Transformants were isolated by screening for the appropriate antibiotic resistance. FACS analysis revealed that the final A. actinomycetemcomitans-GFP integrant exhibited slightly more intense fluorescence than wild-type A. actinomycetemcomitans. These data demonstrate that transposon-mediated chromosomal integration is a useful approach for constructing mutant A. actinomycetemcomitans strains.
A Preliminary Numerical Study on the Interactions Between Nonlinear Ultrasonic Guided Waves and a Single Crack in Bone Materials With Motivation to the Evaluation of Micro Cracks in Long Bones

Fatigue damage in a bone occurs in the form of micro-scale cracks with the lengths as small as to a few microns. The evaluation of cracks in bones has recently been a hot topic. However, the current most frequently used method is based on traditional linear ultrasound, which is just sensitive to gross damages rather than micro cracks. Nonlinear ultrasonic technique, which is capable of detecting micro-scale damages, has been widely used in metallic structures. However, few study has been directed to employing second harmonic generation of nonlinear ultrasound to evaluate fatigue damages in bones. In this study, a preliminary study is conducted on the interactions between nonlinear guided waves and a single crack in bone materials motivating to the evaluation of micro cracks in long bones. Considering the symmetry, asymmetry, location, orientation, length and width of the crack in bone materials, their influences on second harmonic responses are discussed in detail. Our results are presented as follows. Firstly, not only the primary S0 but also A0 mode Lamb wave generates the second harmonic component of S0 mode after interacting with a symmetric crack. Secondly, along the thickness direction, the primary S0 mode Lamb wave possesses almost the same detection sensitivity, no matter where the crack is located. Thirdly, the amplitudes of S0 mode second harmonic component are increased slightly when the oblique angle of the crack is set from 0°to 45°, while the amplitudes increase dramatically when the oblique angle changes to 67.5° and 90°. Lastly, the second harmonic amplitude and the relative acoustical nonlinear parameter are increased with the length of the crack, while they possess a monotonically decreasing relationship with the width of the crack. Our preliminary studies will provide priori knowledge when using nonlinear ultrasonic guided waves for detecting micro-scale cracks in long bones in future clinical inspections.
Clinical and imaging features predict mortality in COVID-19 infection in Iran

The new coronavirus disease 2019 (COVID-19) pandemic has challenged many healthcare systems around the world. While most of the current understanding of the clinical features of COVID-19 is derived from Chinese studies, there is a relative paucity of reports from the remaining global health community. In this study, we analyze the clinical and radiologic factors that correlate with mortality odds in COVID-19 positive patients from a tertiary care center in Tehran, Iran. A retrospective cohort study of 90 patients with reverse transcriptase-polymerase chain reaction (RT-PCR) positive COVID-19 infection was conducted, analyzing demographics, co-morbidities, presenting symptoms, vital signs, laboratory values, chest radiograph findings, and chest CT features based on mortality. Chest radiograph was assessed using the Radiographic Assessment of Lung Edema (RALE) scoring system. Chest CTs were assessed according to the opacification pattern, distribution, and standardized severity score. Initial and follow-up Chest CTs were compared if available. Multiple logistic regression was used to generate a prediction model for mortality. The 90 patients included 59 men and 31 women (59.4 ± 16.6 years), including 21 deceased and 69 surviving patients. Among clinical features, advanced age (p = 0.02), low oxygenation saturation (p<0.001), leukocytosis (p = 0.02), low lymphocyte fraction (p = 0.03), and low platelet count (p = 0.048) were associated with increased mortality. High RALE score on initial chest radiograph (p = 0.002), presence of pleural effusions on initial CT chest (p = 0.005), development of pleural effusions on follow-up CT chest (p = 0.04), and worsening lung severity score on follow-up CT Chest (p = 0.03) were associated with mortality. A two-factor logistic model using patient age and oxygen saturation was created, which demonstrates 89% accuracy and area under the ROC curve of 0.86 (p<0.0001). Specific demographic, clinical, and imaging features are associated with increased mortality in COVID-19 infections. Attention to these features can help optimize patient management.
The Role of Thermal Water in Chronic Skin Diseases Management: A Review of the Literature

The benefits of thermal water in different diseases have been known since ancient times. Over the past decades, a re-assessment of the use of mineral water for the treatment of several pathologic conditions has taken place around the world. Today, water therapy is being practiced in many countries that have a variety of mineral springs considerably different in their hydrogeologic origin, temperature, and chemical composition. Thermal water and balneotherapy offer several advantages: this approach needs no chemicals or potentially harmful drugs; there are almost no side effects during and after treatment, and there is a low risk to the patient’s general health and well-being. However, it is difficult to evaluate the efficacy of this therapeutic approach in clinical practice due to the complexity of molecular mechanisms underlying its efficacy. Here we review the current knowledge of the chemical, immunological, and microbiological basis for therapeutic effects of thermal water with a specific focus on chronic inflammatory skin diseases. We also describe recent evidence of the major dermatologic diseases that are frequently treated by balneotherapy with a remarkable rate of success. Moreover, we discuss the potential role of balneotherapy either alone or as a complement to conventional medical treatments.
Effects of Pre- and Postharvest Calcium Treatments on Shelf Life and Postharvest Quality of Broccoli Microgreens

We reported previously that the preharvest treatment of broccoli microgreens with 10 mmol · L L 1 calcium chloride (CaCl 2 ) increased the yield and postharvest quality. The objective of this study was to investigate whether other calcium forms have the similar effect, in particular, after postharvest dip in calcium solution. Our results are as follows: 1) Preharvest spray without postharvest dip: Both 20 mmol · L L 1 calcium lactate (Ca lactate) and calcium amino acid (Ca AA) chelate signiﬁcantly improved broccoli microgreens quality and inhibited microbial populations as compared with the wateronly control during storage at 5 8 C for 21 days. However, they were less effective than 10 mmol · L L 1 CaCl 2 . 2) Postharvest dip without preharvest spray: The microgreens sprayed with water-only control were dipped in 0, 25, 50, or 100 mmol · L L 1 Ca lactate solution containing 100 m L · L L 1 chlorine immediately after harvest. During storage at 5 8 C for 14 days, 50 mmol · L L 1 Ca lactate dip showed the highest overall quality and lowest tissue electrolyte leakage. 3) Preharvest spray and postharvest dip: Combined preharvest 10 mmol · L L 1 CaCl 2 spray and postharvest 50
The effect of resource depletion on the feeding behaviour of a browser : winter foraging by moose on Scots pine

(1) The foraging dynamics of a browser, the moose Alces alces L. exploiting depleting resources was studied experimentally. It was hypothesized that: (a) differences in the intake of twig biomass between tree stands in early foraging sessions would tend to even out as resource depletion progressed; (b) food item selectivity within stands would decrease, and (c) bite diameters would increase with time. (2) Artificial stands, composed of one browse species or a mixture of species, were set up in a forest area. The species included were Scots pine Pinus sylvestris L. , aspen Populus tremula L. and grey alder Alnus incana (L.) Moench. Special attention was paid to the analysis of the pattern of Scots pine exploitation because this tree is of commercial interest. Moose browsing was assessed by counting bites and by measuring bite diameters. (3) Initially the total consumption of twig biomass in the pine + aspen stand was twice as high as that in the other two stands. This difference remained until almost half of the available biomass in the pine + aspen stand had been consumed. Within stands the preference for aspen over pine increased over time, whereas the preference for pine over alder decreased. Bite diameter on Scots pine showed a significant decline over time. (4) Browsing on Scots pine was only slightly affected by the species composition of the tree mixtures. Browsing intensities on individual pines was positively correlated with the amounts consumed on adjacent stems.
Double Internalization and Exchange Fee Bias

Payment platforms o⁄er intermediation services to consumers and merchants that interact on a product market. The merchant(cid:146)s bank (the acquirer) usually pays an interchange fee to the consumer(cid:146)s bank (the issuer) that impacts the allocation of the total transaction fee between consumers and merchants. This paper studies whether a monopolistic payment platform chooses an interchange fee that exceeds the socially optimal one when there is "double internalization". We refer to "double internalization" as a situation in which both consumers and merchants internalize a fraction of the other side(cid:146)s net costs of transacting on the platform. We show that double internalization may occur when the interchange fee impacts consumers(cid:146)decisions on the product market and compare the pro(cid:133)t-maximizing interchange fee to the welfare-maximizing one. fee. In (ii), we show that the platform(cid:146)s pro(cid:133)t is independent of the interchange fee when market structures are symmetric on both sides. In (iii), we determine the pro(cid:133)t-maximizing interchange fee when market structures are asymmetric. In (iv), we provide the second-order conditions for pro(cid:133)t-maximization when the market structures are asymmetric. In (v), we provide the conditions under which the card market on the merchant side is not covered in equilibrium.