Miracle-dz/UniFAR-FTUs huggingface dataset:
Contextual Factors Affecting Risky Decision Making: The Influence of Music on Task Performance and Perceived Distraction

Previous research has investigated factors that contribute to the development of different risk-taking behaviors, such as can occur on lab-based behavioral risky decision making tasks. On several of the most common tasks, participants must develop an adequate understanding of the relative risks and benefits associated with each decision in order to learn to decide advantageously. However, contextual factors can affect the decision making process and one’s ability to weigh the risks and benefits of a decision. The present study investigates the extent to which music may be an additional contextual factor that can disrupt decision making and other executive functions. Across four studies we examine whether having music playing passively in the background or having participants actively listen to music affects performance on measures of risky decision making, working memory, processing speed, and problem solving. Participants reported greater distraction for rock music than classical music in the passive listening studies but did not report any differences in distraction across conditions in the active listening studies. Despite this self-reported increased level of distraction, few significant differences were found in task performance across groups and across studies. The Angling Risk Task (ART) was sensitive to differences in risk by condition, with music leading to greater risk-taking in a passive listening study, but less risk-taking in an active listening study, compared to no music. The extent to which music serves as a contextual factor disrupting performance on measures of risky decision making and other executive functions may depend in part on whether individuals are actively versus passively listening to the music.
Effect of Exercise Training on Physical Fitness Among Young Tennis Players: A Systematic Review

Background Physical fitness comprises both health- and skill-related components that have been shown to correlate with the competitive ability of the athletes. Competitive ability of the athletes is strongly related to the positive or poor characteristics of physical fitness. Additionally, the adolescent stage is critical for the development of physical fitness. Physical fitness training for young tennis players should receive more attention. However, the current literature is deficient in in-depth reviews of the effects of exercise training on the physical fitness of young tennis players. Objective This review is aimed to investigate the effects of exercise training on physical fitness among young tennis players. Methods From October 2020, a comprehensive search was undertaken in four electronic databases (SCOPUS, PubMed, EBSCOhost (SPORTDiscus), and CINAHL Plus) and also on Google Scholar and other sources of gray literature references. The methodological quality of included studies was assessed using the Physiotherapy Evidence Database scale and the over scientific evidence was determined using the best evidence synthesis (BES). This review included only studies that employed an experimental design to assess the physical fitness components of young tennis players. Results Nine articles on exercise training met all inclusion criteria and were included in this systematic review. The studies were of a high standard of quality. The research findings are relatively credible. The results indicated that speed (n = 8) and agility (n = 8) were the most often investigated performance characteristics in exercise training interventions with young tennis players, followed by power (n = 7), strength (n = 4), and flexibility (n = 1). Exercise training significantly increased the physical fitness of young tennis players in terms of speed and agility. There is a lack of evidence about strength and flexibility. Meanwhile, there is conflicting evidence regarding the effect on power, and yet there is no evidence regarding the effect of exercise training on endurance. Conclusions This systematic review established a compelling case for the beneficial effects of exercise training interventions on physical fitness in youngtennis players. The review identifies current research gaps (i.e., athlete gender, with a particular emphasis on female athletes) that should be addressed in future experimental studies. Systematic Review Registration https://www.crd. york.ac. uk/prospero, identifier CRD 42020213145.
The Longitudinal Association of Subclinical Hearing Loss With Cognition in the Health, Aging and Body Composition Study

Objectives To examine the longitudinal association between subclinical hearing loss (SCHL) and neurocognitive performance. Design Longitudinal analyses were conducted among 2,110 subjects who underwent audiometric testing in a US multi-centered epidemiologic cohort study. The primary exposure was better ear hearing (pure tone average). SCHL was defined as hearing ≤ 25 dB. The primary outcome was neurocognitive performance, measured by Digit Symbol Substitution Test (DSST), Modified Mini Mental State Examination (3MS), and CLOX1. Linear mixed models were performed to assess the longitudinal association between hearing and cognitive performance, adjusting for covariates. Models were fit among all individuals and among individuals with SCHL only. Results Among 2,110 participants, mean (SD) age was 73.5 (2.9) years; 52.3% were women. Mean (SD) better ear pure tone average was 30.0 (13.1) dB. Mean follow-up was 9.1 years (range 3–16). Among all participants, worse hearing was associated with significantly steeper cognitive decline measured by the DSST [0.054-point/year steeper decrease per 10 dB worse hearing, 95% confidence interval (CI): 0.026–0.082] and 3MS (0.044-point/year steeper decrease per 10 dB worse hearing, CI: 0.026–0.062), but not CLOX1. Among those with SCHL, worse hearing was associated with significantly steeper cognitive performance decline as measured by DSST (0.121-point/year steeper decrease per 10 dB worse hearing, CI: 0.013–0.228), but not CLOX1 or 3MS. Conclusion Among those with SCHL, worse hearing was associated with steeper cognitive performance declines over time as measured by DSST. The relationship between hearing loss and cognition may begin at earlier levels of hearing loss than previously recognized.
Transcriptomic Analysis Reveals the Regulation Mechanism of Sporogenesis in Ulva prolifera

Ulva prolifera, the main causative species of green tide, has drawn much attention. Spore reproduction was one of the main reproduction strategies that could be induced by changing environmental factors, but the mechanism of spore formation remains obscure. Here, we cultured U. prolifera (segments) under the optimal sporulation condition, and four states in total from vegetative to reproductive were defined. Additionally, the chlorophyll fluorescence and transcriptome analysis were determined at these four states. The results showed that: (1) Compared with state I, the photosynthetic capacity (Fv/Fm, Fv′/Fm′, rETRmax) and chlorophyll content (Chl a, Chl b, carotenoids) were enhanced in state II, whereas it decreased in state III and IV (the spore formation period); (2) a total of 41,058 unigenes were expressed during the spore formation process; (3) compared with state I, the genes related with photosynthesis, terpenoid backbone biosynthesis, and carotenoid biosynthesis were significantly upregulated in states II, III, and IV whereas glycolysis was downregulated in state I; (4) some genes of the transcription factors families, such as the C3H family, may be one of the key factors that regulate genes in the spore formation; (5) 574 of the differentially expressed genes (DEGs) associated with flagella biosynthesis were annotated according to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes Orthology, including 20 unigenes encoding intraflagellar transport proteins (IFTs) which had not been reported in previous transcriptome analysis in U. prolifera. This study provides a new perspective of spore formation at the gene transcriptional level, although the detailed transcription regulatory spore formation network remains to be unveiled.
Surgery Treatment of Primary Tumors of the Inferior Vena Cava

Background Primary tumor of the inferior vena cava is a rare tumor, which arises from the smooth muscle of vascular walls. Surgery appears the only curative treatment. However, the optimal surgical methods and surgical management are not well-studied. In this article, we reviewed the successful treatment experience of patients in our center who had resection of primary tumor of the inferior vena cava and reviewed the relevant literature. Methods Four cases of patients who undergoing initial resection of primary tumors of the inferior vena cava from September 2017 to August 2021 in the Second Affiliated Hospital of Nanchang University were screened and followed up. They were discussed and cases reported in this field were reviewed. Results Among the four patients, three of them were female. The median age of the disease is 53.75 years (range 45–60 years). After surgical treatment, tumors were removed in all patients, and some patients had reconstruction of inferior vena cava. There were no disease-specific deaths, no serious complications, and no recurrence during follow-up in these cases. Conclusions Careful preoperative examination, correct surgical treatment methods, and multidisciplinary collaboration can lead to safe and successful operations, which improve the survival rate of patients.
Associations of Suicide Risk and Community Integration Among Patients With Treatment-Resistant Depression

Introduction Treatment-resistant depression (TRD) is one of the primary causes of disability and a major risk for suicide among patients living in the community. However, the suicide risks and care needs for safety among patients with TRD during the community reintegration process appear to be underestimated. This study aimed to investigate the association between community integration and suicide risks among patients with treatment-resistant depression (TRD) with sub-analysis by gender. Methods Patients diagnosed with major depressive disorder were recruited upon psychiatrists' referral in two general hospitals in northern Taiwan during 2018–2019. The participants who experienced more than two failed treatments of antidepressants with partial remission were defined as TRD. A structured questionnaire was used to collect socio-demographic, suicidality, and psychosocial information. Results In a total of 125 participants, gender difference was identified in certain community integration aspects such as home integration, productivity, and electronic social networking. The male participants appeared to have better involvement in social contact with internet but slightly less video link than women, while women had higher level of home integration in the past month. The participants who performed worse in the social integration and better home-based activity or productivity levels had higher suicide risks including suicide ideation and overall suicide risks. Conclusions Community integration levels of home, social, and productivity were associated with suicidality in terms of overall suicide risk and recent suicide ideation. Facilitation of community integration at home and life arrangements might reduce suicide risks in TRD patients.
Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells

Parkinson’s Disease (PD) is a neurodegenerative disease that affects the elderly. It is associated with motor dysfunction due to the accumulation of misfolded or aggregated fibrillar alpha-synuclein (α-syn) in the mid-brain. Current treatments are mainly focused on relieving the symptoms but are accompanied by side effects and are limited in halting disease progression. Increasing evidence points to peripheral immune cells underlying disease development, especially T cells contributing to α-syn-related neuroinflammation in PD. The onset of these cells is likely mediated by dendritic cells (DCs), whose role in α-syn-specific responses remain less studied. Moreover, Traditional Chinese medicine (TCM)-derived compounds that are candidates to treat PD may alleviate DC-T cell-mediated immune responses. Therefore, our study focused on the role of DC in response to fibrillar α-syn and subsequent induction of antigen-specific T cell responses, and the effect of TCM Curcumin-analog C1 and Tripterygium wilfordii Hook F-derived Celastrol. We found that although fibrillar α-syn did not induce significant inflammatory or T cell-mediating cytokines, robust pro-inflammatory T cell responses were found by co-culturing fibrillar α-syn-pulsed DCs with α-syn-specific CD4+ T cells. Celastrol, but not C1, reduced the onset of pro-inflammatory T cell differentiation, through promoting interaction of endosomal, amphisomal, and autophagic vesicles with fibrillar α-syn, which likely lead to its degradation and less antigen peptides available for presentation and T cell recognition. In conclusion, regulating the intracellular trafficking/processing of α-syn by DCs can be a potential approach to control the progression of PD, in which Celastrol is a potential candidate to accomplish this.
Dissolved Nitrogen Speciation and Concentration During Spring Thaw in the Greenland Ice Sheet Dark Zone: Evidence for Microbial Activity

This study provides the first contemporaneous measurements of the concentration and speciation of dissolved nitrogen (N) in snow, meltwater and ice during the onset of the ablation season at a site within the Dark Zone of the Greenland Ice Sheet. The decaying, partially leached snow pack near S6 in south-west Greenland produced meltwater with relatively constant nitrate (NO3 −) concentrations, approximating the snow pack average (1.1 µM). By contrast, ammonium (NH4 +) (0–∼ 4 µM) and dissolved organic nitrogen (DON) (0–∼ 3 µM) concentrations were more variable, and sometimes higher than the average snow pack concentrations of 1.0 and 0.4 µM, respectively. This variability could be the result of microbial uptake and production within the melting snow pack. We observed pooled meltwater at the snow-ice interface that appeared to scavenge DON (∼1–8 µM) and possibly NO3 − (∼1–2 µM) from the underlying ice, whose initial surface was a continuum of superimposed ice and weathering crust from the previous season. The shallow meteoric ice (∼10 cm–1 m) beneath the snow pack had high concentrations of DON and NH4 +(6.5 and 2.6 µM, respectively), while NO3 − concentrations were similar to the snow pack (1.1 µM). The absence of NH4 + in the snowmelt traversing the snow-ice interface may also point to microbial activity occurring at this boundary layer. Melt modelling indicated the presence of liquid meltwater at the snow-ice interface and that at least 10 cm of the surface ice below the snow pack was at 0°C. Solar radiation transmitted through the thin snow pack to the ice surface is absorbed by pigmented glacier algae causing melt of the surrounding ice, allowing the possibly of photosynthesis to begin under the thinning snowpack in these micro-melt environments. Hence, we conjecture that glacier algal blooms can commence before the snow pack has completely melted, occuring at a time when meltwaters are enhanced in nutrients scavenged from the snowpack, superimposed ice and the remnants of the weathering crust from the previous year.
Factors Influencing Running Performance During a Marathon: Breaking the 2-h Barrier

A few years ago, the brilliant view pointing of Joyner et al. (1) highlighted the physiological determinants of distance running performance, assuming that the barrier of the 2-h marathon would have been overcome in 2021–2022. October 14th 2019, Eliud Kipchoge broke this time barrier, concluding the marathon in 1:59:40. However the record was not homologated because not run under open marathon conditions and achieved with a rotation of 41 professional pacesetters. For the previous reasons, the current record is still 2:01:39, set in 2018 again by Kipchoge. The aim of this article is to update the key factors involved in the running performance.
Promoter Hypomethylation of TGFBR3 as a Risk Factor of Alzheimer’s Disease: An Integrated Epigenomic-Transcriptomic Analysis

Alzheimer’s disease (AD) is characterized by the abnormal deposition of amyloid-β (Aβ) plaques and tau tangles in the brain and accompanied with cognitive impairment. However, the fundamental cause of this disease remains elusive. To elucidate the molecular processes related to AD, we carried out an integrated analysis utilizing gene expression microarrays (GSE36980 and GSE5281) and DNA methylation microarray (GSE66351) in temporal cortex of AD patients from the Gene Expression Omnibus (GEO) database. We totally discovered 409 aberrantly methylated and differentially expressed genes. These dysregulated genes were significantly enriched in biological processes including cell part morphogenesis, chemical synaptic transmission and regulation of Aβ formation. Through convergent functional genomic (CFG) analysis, expression cross-validation and clinicopathological correlation analysis, higher TGFBR3 level was observed in AD and positively correlated with Aβ accumulation. Meanwhile, the promoter methylation level of TGFBR3 was reduced in AD and negatively associated with Aβ level and advanced Braak stage. Mechanically, TGFBR3 might promote Aβ production by enhancing β- and γ-secretase activities. Further investigation revealed that TGFBR3 may exert its functions via Synaptic vesicle cycle, Calcium signaling pathway and MAPK signal pathway by regulating hub genes GNB1, GNG3, CDC5L, DYNC1H1 and FBXW7. Overall, our findings highlighted TGFBR3 as an AD risk gene and might be used as a diagnostic biomarker and therapeutic target for AD treatment.
Diffusion Tensor Imaging Revealed Microstructural Changes in Normal-Appearing White Matter Regions in Relapsing–Remitting Multiple Sclerosis

Background Axons and myelin sheaths are the physical foundation for white matter (WM) to perform normal functions. Our previous study found the metabolite abnormalities in frontal, parietal, and occipital normal-appearing white matter (NAWM) regions in relapsing–remitting multiple sclerosis (RRMS) patients by applying a 2D 1H magnetic resonance spectroscopic imaging method. Since the metabolite changes may associate with the microstructure changes, we used the diffusion tensor imaging (DTI) method to assess the integrity of NAWM in this study. Method Diffusion tensor imaging scan was performed on 17 clinically definite RRMS patients and 21 age-matched healthy controls on a 3.0-T scanner. DTI metrics including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were extracted from 19 predefined regions of interest (ROIs), which were generated by removing a mask of manually drawn probabilistic lesion map from the Johns Hopkins University white-matter atlas. The mean values of FA, MD, AD, and RD were compared between different groups in the same ROIs. Results A probabilistic lesion map was successfully generated, and the lesion regions were eliminated from the WM atlas. We found that the RRMS patients had significantly lower FA in the entire corpus callosum (CC), bilateral of anterior corona radiata, and right posterior thalamic radiation (PTR). At the same time, RRMS patients showed significantly higher MD in the bilateral anterior corona radiata and superior corona radiata. Moreover, all AD values increased, and the bilateral external capsule, PTR, and left tapetum NAWM show statistical significance. What is more, all NAWM tracts showed increasing RD values in RRMS patients, and the bilateral superior corona radiata, the anterior corona radiata, right PTR, and the genu CC reach statistical significance. Conclusion Our study revealed widespread microstructure changes in NAWM in RRMS patients through a ready-made WM atlas and probabilistic lesion map. These findings support the hypothesis of demyelination, accumulation of inflammatory cells, and axonal injury in NAWM for RRMS. The DTI-based metrics could be considered as potential non-invasive biomarkers of disease severity.
A Systematic Review of Tissue and Single Cell Transcriptome/Proteome Studies of the Brain in Multiple Sclerosis

Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system (CNS). Although inflammatory responses are efficiently treated, therapies for progression are scarce and suboptimal, and biomarkers to predict the disease course are insufficient. Cure or preventive measures for MS require knowledge of core pathological events at the site of the tissue damage. Novelties in systems biology have emerged and paved the way for a more fine-grained understanding of key pathological pathways within the CNS, but they have also raised questions still without answers. Here, we systemically review the power of tissue and single-cell/nucleus CNS omics and discuss major gaps of integration into the clinical practice. Systemic search identified 49 transcriptome and 11 proteome studies of the CNS from 1997 till October 2021. Pioneering molecular discoveries indicate that MS affects the whole brain and all resident cell types. Despite inconsistency of results, studies imply increase in transcripts/proteins of semaphorins, heat shock proteins, myelin proteins, apolipoproteins and HLAs. Different lesions are characterized by distinct astrocytic and microglial polarization, altered oligodendrogenesis, and changes in specific neuronal subtypes. In all white matter lesion types, CXCL12, SCD, CD163 are highly expressed, and STAT6- and TGFβ-signaling are increased. In the grey matter lesions, TNF-signaling seems to drive cell death, and especially CUX2-expressing neurons may be susceptible to neurodegeneration. The vast heterogeneity at both cellular and lesional levels may underlie the clinical heterogeneity of MS, and it may be more complex than the current disease phenotyping in the clinical practice. Systems biology has not solved the mystery of MS, but it has discovered multiple molecules and networks potentially contributing to the pathogenesis. However, these results are mostly descriptive; focused functional studies of the molecular changes may open up for a better interpretation. Guidelines for acceptable quality or awareness of results from low quality data, and standardized computational and biological pipelines may help to overcome limited tissue availability and the “snap shot” problem of omics. These may help in identifying core pathological events and point in directions for focus in clinical prevention.
Psychometric Properties of the Revised Dysexecutive Questionnaire in a Non-clinical Population

Aims The aim of this study was to assess the psychometric properties of the revised self-rated version of the Dysexecutive Questionnaire (DEX-R) within a non-clinical sample. Methods The study was hosted online, with 140 participants completing the DEX-R, GAD-2 and PHQ-2. Sixty participants also completed the FrSBe, with 99 additionally completing the DEX-R again 3 weeks later. Correlations with demographic factors and symptoms of anxiety and depression were conducted. Rasch and factor analysis were also used to explore underlying subconstructs. Results The DEX-R correlated highly with the FrSBe, indicating sound concurrent validity. Internal consistency, split-half reliability and test-retest reliability were excellent. Age and symptoms of depression and anxiety correlated with DEX-R scores, with older age associated with less dysexecutive problems. The Rasch analysis confirmed the multidimensionality of the rating scale, and a three-factor structure was found relating to activation-self-regulatory, cognitive and social-emotional processes. Frequencies of responses on DEX-R items varied, many were not fully endorsed indicating specific relevance of most but not all items to patients. Conclusion Interpretations of DEX-R ratings of dysexecutive problems should consider mood and individual variation. Systematic comparison of DEX-R responses between healthy and clinical groups could help identify a suitable cut off for dysexecutive symptoms.