Miracle-dz/UniFAR-FTUs huggingface dataset:
Natural sorting over permutation spaces

0. Introduction. In this paper we continue the study, begun in [1], of some combinatorial problems related to monotonicities that occur in certain spaces of finite sequences. These spaces are equipped with standard probability measures, so that one may study the distribution of monotonicities in such spaces and, in particular, the expected lengths of maximal monotonie subsequences. These, in turn, are upper bounds on the expected lengths of monotonie subsequences obtained by applying some selection process over the space of sequences. The problem which we have called natural sorting is concerned with the maximization of these expected lengths. The scheme of the paper is as follows. In Section 1 we give definitions and review some background material. In Section 2 we describe the distribution of maximal sequences occurring in the space of permutation sequences. * These distributions have been computed exactly for spaces of permutations of length n = 2(1)36, and have been approximated by Monte Carlo computations for certain values of n ranging up to 10,000. In Section 3 we consider several selection strategies and the corresponding distribution of selected monotonie subsequences. The computations were performed on the IBM 7094 at the Computer Center of the University of California, Berkeley. We are indebted to David M. Matula for some of the calculations in Section 3. We should like to thank Geri Stephen for her assistance in the preparation of the manuscript.
Approaching the theoretical strength in nanoporous Au

The mechanical properties of nanoporous Au have been investigated by uniaxial compression. Micron-sized columns were machined in the surface of nanoporous Au using a focused Ga+ beam and compressed with a flat punch in a nanoindenter. Using scaling laws for foams, the yield strength of the 15nm diameter ligaments is estimated to be 1.5GPa, close to the theoretical strength of Au. This value agrees well with extrapolations of the yield strength of submicron, fully dense gold columns and shows that in addition to foam density and structure, the absolute size of ligaments and cell walls can be used to tailor foam properties.The mechanical properties of nanoporous Au have been investigated by uniaxial compression. Micron-sized columns were machined in the surface of nanoporous Au using a focused Ga+ beam and compressed with a flat punch in a nanoindenter. Using scaling laws for foams, the yield strength of the 15nm diameter ligaments is estimated to be 1.5GPa, close to the theoretical strength of Au. This value agrees well with extrapolations of the yield strength of submicron, fully dense gold columns and shows that in addition to foam density and structure, the absolute size of ligaments and cell walls can be used to tailor foam properties.
Relationship Between Mindfulness and Physical Activity in College Students: The Mediating Effect of Eudaimonic Well-Being

Previous research has shown many benefits of mindfulness for physical and psychological health, including its link to such health behaviors as increased physical activity (PA). We re-examined the association between mindfulness and PA to better understand a possible mediating role of eudaimonic well-being in this association, while controlling for participants’ age, gender, and affect. We had 738 undergraduate student participants (45.0% females; M age = 19.58 years) complete measures of trait mindfulness, eudaimonic well-being, and PA, and we used age, gender, and affect as covariates in a single-wave assessment. We conducted this mediation analysis with a bootstrapping technique to produce 10,000 resamples. We replicated findings of a significant relationship between mindfulness and enhanced eudaimonic well-being (β = 0.474, p < 0.001), which in turn contributed to increased PA (β = 0.193, p < 0.001). The bootstrapping method indicated a significant indirect effect of eudaimonic well-being (β = 0.092, 95% CI = [0.043, 0.142]) in the relationship between mindfulness and PA through eudaimonic well-being. Thus, eudaimonic well-being may mediate the connection between mindfulness and PA. College administrators should consider incorporating mindfulness into health promotion programs as a means of enhancing college students’ well-being and health behaviors.
Does exposure to research experiences have different learning outcomes than prior exposure to lab techniques in non‐research settings?

A large body of literature has established the benefits of undergraduate research experiences via the traditional apprenticeship model. More recently, several studies have shown that many of these benefits can be recapitulated in course‐based undergraduate research experiences (CUREs) that are more scalable and easier for students to participate in, compared to the apprenticeship‐based research experiences. Many Biology curricula also incorporate more traditional laboratory courses, where students learn to use common laboratory techniques through guided exercises with known outcomes. Indeed, many programs across the nation provide such programs or courses for students early in their careers, with a view toward increasing student interest and engagement in Biology. While there is general consensus that all lab experiences have some benefits for students, very few studies have examined whether either research experiences or learning biological techniques in more traditional lab courses directly impacts student performance in lecture courses. Here, we show that prior familiarity with laboratory techniques does not improve student performance in a lecture course, even if these techniques are directly related to content being taught in the course. However, having prior research experience improves performance in the course, irrespective of whether the research experience included the use of course‐related laboratory techniques.
Multiperiodic Variability in Magellanic Cloud Be/X-Ray Binaries

The long-term photometric behavior of seven Be–neutron star binaries in the Magellanic Clouds has been examined using MACHO and OGLE-II data. All show small periodic outbursts, which we associate with the periastron passage of the neutron star and its interaction with the Be star's disk. Five of these systems are known X-ray pulsars. The orbital periods we find for these pulsars fall near the "Corbet" relation for orbital versus pulse periods for Be/X-ray binaries. In four systems we detect a previously unrecognized type of quasi-periodic variation that is present between the orbital outbursts. These variations may be related to the rotation of the disk.
ON AUTOMORPHISMS OF AFFINE KAC-MOODY ALGEBRAS

In this paper, we first give some properties of automorphisms of affine Kac-Moody algebras. Then we present a classification of order three automorphisms. An explicit, complete and non-redundant set of conjugacy classes of order 3 automorphisms is given and the fixed point sets are computed for each conjugacy class. Finally we study finite order inner automorphisms of the first kind. For a positive integer m, we identify the order m automorphisms with sequences of non-negative integers and give an explicit classification. As a consequence, we list the conjugacy classes of lower order automorphisms.
Transdiagnostic treatment of depression and anxiety: a meta-analysis

Abstract Background In the past 10 years an increasing number of randomised trials have examined the effects of transdiagnostic treatments of patients with depression or anxiety. We conducted the first comprehensive meta-analysis of the outcomes of this emerging field. Methods We used the searches in PubMed, PsychINFO, Embase and the Cochrane library of an existing database of randomised trials of psychological interventions for depression to identify studies comparing a transdiagnostic treatment of patients with depression or anxiety with a control group (deadline 1 January 2022). We conducted random-effects meta-analyses and examined the effects on depression and anxiety at the short and longer term. Results We included 45 randomised controlled trials with 51 comparisons between a psychotherapy and a control group and 5530 participants. Thirty-five (78%) studies were conducted in the last 10 years. The overall effect size was g = 0.54 (95% CI 0.40–0.69; NNT = 5.87), with high heterogeneity (I2 = 78; 95% CI 71–83), and a broad PI (−0.31–1.39). The effects remained significant in a series of sensitivity analyses, including exclusion of outliers, adjustment for publication bias, for studies with low risk of bias, and in multilevel analyses. The results were comparable for depression and anxiety separately. At 6 months after randomisation the main effects were still significant, but not at 12 months, although the number of studies was small. Conclusions Transdiagnostic treatments of patients with depression or anxiety are increasingly examined and are probably effective at the short term.
Peierls instabilities in covalent structures

We study the instabilities of p-bonded systems with a particular emphasis on the structure of group-V and -VI elements. We show that the trivalency of As (respectively divalency of Se and Te) is due to the Peierls instability of a half-filled band (respectively two-third-filled band). A moment calculation shows that the periodicity is not a necessary condition for the Peierls instability. Consequently, the trivalency of As (respectively, divalency of Se, Te) also holds in disordered structures (liquid, amorphous structures), as has been shown experimentally. We also study the pressure dependence of the instability: a bifurcation point is observed for a given pressure, above which no distortion appears.
THE KORSELT SET OF pq

Let α ∈ ℤ\{0}. A positive integer N is said to be an α-Korselt number (Kα-number, for short) if N ≠ α and N - α is a multiple of p - α for each prime divisor p of N. By the Korselt set of N, we mean the set of all α ∈ ℤ\{0} such that N is a Kα-number; this set will be denoted by . Given a squarefree composite number, it is not easy to provide its Korselt set and Korselt weight both theoretically and computationally. The simplest kind of squarefree composite number is the product of two distinct prime numbers. Even for this kind of numbers, the Korselt set is far from being characterized. Let p, q be two distinct prime numbers. This paper sheds some light on .
Single-cell RNA sequencing analyses: interference by the genes that encode the B-cell and T-cell receptors

Abstract B and T cells are integral parts of the immune system and are implicated in many diseases, e.g. autoimmunity. Towards understanding the biology of B and T cells and subsets thereof, their transcriptomes can be analyzed using single-cell RNA sequencing. In some studies, the V(D)J transcripts encoding the variable regions of the B- and T-cell antigen receptors have been removed before the analyses. However, a systematic analysis of the effects of including versus excluding these genes is currently lacking. We have investigated the effects of these transcripts on unsupervised clustering and down-stream analyses of single-cell RNA sequencing data from B and T cells. We found that exclusion of the B−/T-cell receptor genes prior to unsupervised clustering resulted in clusters that represented biologically meaningful subsets, such as subsets of memory B and memory T cells. Furthermore, pseudo-time and trajectory inference analyses of early B-lineage cells resulted in a developmental pathway from progenitor to immature B cells. In contrast, when the B−/T-cell receptor genes were not removed, with the PCs used for clustering consisting of up to 70% V-genes, this resulted in some clusters being defined exclusively by V-gene segments. These did not represent biologically meaningful subsets; for instance in the early B-lineage cells, these clusters contained cells representing all developmental stages. Thus, in studies of B and T cells, to derive biologically meaningful results, it is imperative to remove the gene sequences that encode B- and T-cell receptors.
Screening and activity of potential gastrointestinal probiotic lactic acid bacteria against Yersinia ruckeri O1b.

Yersiniosis of cultured Atlantic salmon is a recurrent fish health management challenge in many continents. The causative organism, Yersinia ruckeri, can reside latently in the gut and lead to acute infection and disease during hatchery and sea-transfer stages. One potential prevention approach is the administration of probiotic bacteria to suppress gut colonization of Y. ruckeri. Our study aimed to isolate and identify anti-Yersinia activity among lactic acid bacteria (LAB) isolated from the gastrointestinal tract (GIT) of aquatic animals. Of the 186 aquatic GIT isolates examined, three strains showed diffusible antimicrobial activity towards Y. ruckeri O1b. Analysis of 16 s rRNA gene sequences indicated the three bacterial strains were Enterococci, related to Enterococcus sp. (99%), Enterococcus thailandicus (99%), and Enterococcus durans (99%). Anti-Yersinia activity was maintained at neutral pH (~6.5-7.0), and in-vitro environmental tolerance assays showed the three strains could withstand simulated salmonids gastrointestinal tract conditions of: low pH (3.4) and 3% bile salt content. All three Enterococci strains showed higher adhesion to the intestinal mucus of Atlantic salmon than Y. ruckeri O1b (E. durans 24%, E. enterococcus sp. 25% and E. thailandicus 98%, compared to Y. ruckeri O1b 5%). However, only Enterococcus sp. and E. thailandicus were able to grow in the salmon intestinal mucus broth while E. durans showed no growth. Anti-Yersinia activity was completely inactivated by proteinase-K treatment, suggesting that the active compound/s are proteinaceous and may be bacteriocin-like inhibitory substances (BLIS). Our data indicate that Enterococcus sp. MA176 and E. thailandicus MA122 are potential probionts for the prevention of yersiniosis in salmonids. Further in-vivo studies are required to determine whether these bacteria reduce the incidence of yersiniosis in Atlantic salmon.
Hematological and genetic profiles of persons with co‐inherited heterozygous β‐thalassemia and supernumerary α‐globin genes

Thalassemias are common monogenic autosomal recessive hemoglobin disorders. The usually asymptomatic heterozygotes (β‐thalassemia traits, βTT) may rarely develop non‐transfusion‐dependent‐thalassemia (NTDT) due to co‐inheritance of supernumerary α‐globin genes. Literature on phenotypic/genotypic features of these rare combinations is limited.
Hydrodynamic Modeling of Dam-Reservoir Response during Earthquakes

A computational model is developed to analyze the hydrodynamic behavior of dam reservoirs during earthquakes. The math- ematical model is based on the solution of two-dimensional (2D) Navier-Stokes equations in a vertical, semi-infinite domain truncated by a far-end boundary condition. A depth integrated continuity equation is used to track the deforming free-surface and ensure global mass conservation. A combination of Sommerfeld nonreflecting boundary and dissipation zone methods is implemented at the far end of the reservoir to prevent any back-reflections of pressure and free-surface waves. Nondimensionalized equations are used to compare contribu- tions of each type of force to the development of the hydrodynamic pressure field and to the maximum run-up of free-surface waves on the dam face. Sinusoidal ground accelerations are applied to an idealized dam-reservoir system to analyze the system response. It is observed that the acoustic wave equation solution gives satisfactory results for the pressure field unless the contributions from the free-surface waves become significant at low reservoir depths. The surface wave run-up on the dam face is found to depend on the ground velocity, oscillation period, and the water depth. On the basis of numerical experiments, an expression for the wave run-up to predict conditions of overtopping from probable earthquake characteristics is proposed. DOI: 10.1061/(ASCE)EM.1943-7889.0000322. © 2012 American Society of Civil Engineers. CE Database subject headings: Wave runup; Hydrodynamic pressure; Earthquakes; Dam safety; Free surfaces; Reservoirs. Author keywords: Wave run-up; Hydrodynamic pressure; Earthquakes; Dam safety; Free-surfaces; Reservoirs; Resonance.
Attitudes of women with gestational diabetes toward diet and exercise: a qualitative study

Abstract Objective Gestational diabetes (GDM) refers to glucose intolerance of varying severity first occurring in pregnancy. Following a diagnosis of GDM, exercise and dietary modification has a positive effect on improving glycemic control. Lifestyle changes affected in pregnancies affected by GDM have beneficial effects on long-term health if continued following birth. In addition, the psychological impact of a diagnosis of GDM should not be overlooked. Reports of maternal stress, anxiety, and fear are commonly reported issues in the literature. Support, both socially and from health care professionals, is also linked with higher rates of success in GDM management. Research to date had focused on women’s reaction to a diagnosis of GDM, their mood and quality of life following a diagnosis, and their knowledge or opinions on the management of GDM. This qualitative study explored the attitudes of women with GDM toward these lifestyle changes, specifically diet and exercise. Women were also asked to identify advice that would be useful for other women newly diagnosed with GDM. Methods With ethical approval a qualitative study was conducted using semi-structured interviews which were examined using Thematic Analysis. Patients were invited to participate and gave written consent after a discussion with a study researcher. The question plan for semi-structured interviews was designed with the advice of patient advocates. Recurrent themes were developed until the saturation of data. Results Thirty-two women took part in the study. Time, convenience, and lack of educational awareness were common barriers to healthy eating and physical activity plans. Enablers for change included meal planning and organization. Women regarded their diets pre-diagnosis as healthy, with small “tweaks” (such as portion control) required to comply with recommendations. Another significant facilitator to change was support from the woman’s partner. This also set a benchmark for plans of diet maintenance within the family structure after pregnancy. Unlike dietary changes, a consistent theme was that exercise was considered a “chore” in managing GDM and was unlikely to be continued in the long term. Practical advice offered by participants for other women with GDM included organization, realistic approaches, and lack of self-blame. Conclusion Women reported that changes in diet would be more achievable in the long term than changes in exercise patterns. Partners and the clinical team were significant sources of support. Women’s views are crucial to providing clinicians with a comprehensive and holistic understanding of disease management. Involving women in self-care decisions and empowering women to manage their own health are key contributors to long-term behavior change as well as service provision and policy implementation
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia

Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below the detection limit of clinical assays. However, some individuals experience persistent nonsuppressible viremia (NSV) originating from CD4+ T cell clones carrying infectious proviruses. Defective proviruses represent over 90% of all proviruses persisting during ART and can express viral genes, but whether they can cause NSV and complicate ART management is unknown. Methods We undertook an in-depth characterization of proviruses causing NSV in 4 study participants with optimal adherence and no drug resistance. We investigated the impact of the observed defects on 5′-leader RNA properties, virus infectivity, and gene expression. Integration-site specific assays were used to track these proviruses over time and among cell subsets. Results Clones carrying proviruses with 5′-leader defects can cause persistent NSV up to approximately 103 copies/mL. These proviruses had small, often identical deletions or point mutations involving the major splicing donor (MSD) site and showed partially reduced RNA dimerization and nucleocapsid binding. Nevertheless, they were inducible and produced noninfectious virions containing viral RNA, but lacking envelope. Conclusion These findings show that proviruses with 5′-leader defects in CD4+ T cell clones can give rise to NSV, affecting clinical care. Sequencing of the 5′-leader can help in understanding failure to completely suppress viremia. Funding Office of the NIH Director and National Institute of Dental and Craniofacial Research, NIH; Howard Hughes Medical Institute; Johns Hopkins University Center for AIDS Research; National Institute for Allergy and Infectious Diseases (NIAID), NIH, to the PAVE, BEAT-HIV, and DARE Martin Delaney collaboratories.
Intercomparison of Odin/SMR ozone measurements with MIPAS and balloon sonde data

The Sub-Millimetre Radiometer (SMR) on board Odin measures various important atmospheric species, including stratospheric ozone. In this study we compare the three versions (v1.2, v2.0 and v2.1) of level 2 Odin/SMR global stratospheric ozone data to coincident level 2 MIPAS V4.61 and balloon sonde stratospheric ozone data during 2003. The most current product from Odin/SMR (at time of writing), the v2.1, showed the smallest systematic differences when compared to coincident MIPAS and sonde data. Between 17 and 55 km, v2.1 values agreed with MIPAS within 10% (a maximum of 0.42 ppmv), while comparisons to sonde measurements showed an agreement of typically 5-10% between 22 and 35 km (less than 0.5 ppmv below 33 km). Tropical latitudes below 35 km preseneted the largest absolute systematic differences between v2.1 and sonde coincidences, where Odin/SMR was systematically lower by ~0.9 ppmv (more than 10% difference) at approximately 30 km. Comparisons concerning the previous two Odin/SMR versions showed much larger systematic differences, especially at the higher and lower stratospheric altitudes. The main conclusion here is that we suggest that v2.1 of Odin/SMR ozone data should be used for scientific studies.