Miracle-dz/UniFAR-FTUs huggingface dataset:
Periodic Heat Stress Licenses EMSC Differentiation into Osteoblasts via YAP Signaling Pathway Activation

Background The repair and regeneration of large bone defects represent highly challenging tasks in bone tissue engineering. Although recent studies have shown that osteogenesis is stimulated by periodic heat stress, the thermal regulation of osteogenic differentiation in ectomesenchymal stem cells (EMSCs) is not well studied. Methods and Results In this study, the direct effects of periodic heat stress on the differentiation of EMSCs into osteoblasts were investigated. EMSCs derived from rat nasal respiratory mucosa were seeded onto culture plates, followed by 1 h of heat stress at 41°C every 7 days during osteogenic differentiation. Based on the results of the present study, periodic heating increases alkaline phosphatase (ALP) activity, upregulates osteogenic-related proteins, and promotes EMSC mineralization. In particular, increased YAP nuclear translocation and YAP knockdown inhibited osteogenic differentiation induced by heat stress. Furthermore, the expression and activity of transglutaminase 2 (TG2) were significantly increased after YAP nuclear translocation. Conclusion Together, these results indicate that YAP plays a key role in regulating cellular proteostasis under stressful cellular conditions by modulating the TG2 response.
Quantifying and Predicting Tensile Properties of Curcuma longa-silicone Biocomposite

This study was carried out to introduce newly developed silicone-biocomposite materials, of Curcuma longa-silicone biocomposite; and assess its tensile properties of using the Neo-Hookean hyperelastic constitutive equation. The specimens were prepared from the mix of Curcuma longa fiber and pure silicone at various fiber composition (0 wt.%, 4 wt.%, 8 wt.%, and 12 wt.%). A uniaxial tensile test was carried out by adopting the ASTM D412 testing standard. The Neo-Hookean model was employed to obtain the material constant, C1 value. Results obtained indicate that the incorporation of Curcuma longa fiber improves the stiffness of the silicone biocomposite as can be seen from the increase of the tensile modulus, while marginally decreasing its tensile strength. The material elastic constant, C1 of silicone reinforced with Curcuma longa was then predicted by using Artificial Neural Network (ANN). The regression coefficients obtained by training the neural network are satisfactory, therefore the neural network can be used for predicting the material constant, C1 of the silicone biocomposite. The prediction of ANN generates a better correlation if there are more data set and can be a good fit for predicting the unknown value.
Emerging mucormycosis posing threat to community: Anesthetist's perspective in a tertiary care center

Mucormycosis has become an ever-growing threat to human health, particularly after the COVID-19 pandemic. As the number of cases of mucormycosis increased, it put a burden on anesthesiologists. Here we describe the etiopathogenesis, clinical presentation, and anesthesia management of patients suffering from mucormycosis.
Immunohistochemical Assessment of the P53 Protein as a Predictor of Non-Small Cell Lung Cancer Response to Immunotherapy.

BACKGROUND Determining predictive biomarkers for immune checkpoint inhibitors (ICIs) is a current challenge in oncology. Previous studies on non-small cell lung cancer (NSCLC) have shown how TP53 gene mutations are correlated with different responses to ICIs. Strong and diffuse immuno-expression of p53 by immunohistochemistry (IHC) is interpreted as a likely indicator of a TP53 gene mutation. We aimed to assess the p53 protein expression via IHC in NSCLC as a predictive biomarker of the response to ICIs. METHODS This was a retrospective hospital-based study of patients with NSCLC treated with Nivolumab in the University Hospital of Salamanca. All diagnostic biopsies were studied via IHC (measuring p53 protein expression, peroxidase anti-peroxidase immunohistochemistry technique using Leica BOND Polymer development kits). Survival analysis was performed by subgroups of expression of p53 and other factors using the Kaplan-Meier estimator and Cox proportional-hazards model. RESULTS Seventy-three patients were included (59 men and 14 women). The median age was 68 (44-84) years. Thirty-six biopsies were adenocarcinoma, 34 were squamous, and three were undifferentiated. In 41 biopsies (56.2%), the cellular expression of p53 was <5% (Group A), and in 32 biopsies (43.8%), the expression was ≥5% (Group B). In the general analysis, no differences were observed in overall survival (OS) (A: 12 months vs B: 20 months; p = 0.070) or progression-free survival (PFS) (A: 4 m vs B: 7 m; p = 0.064). Significant differences were observed in adenocarcinomas for both OS (A: 8 m vs B: median not reached; p = 0.002) and PFS (A: 3 m vs 8 m; p = 0.013). No differences in PFS and OS were observed in squamous cell carcinoma. Significant differences were observed in OS in the PD-L1 negative group (0% expression) (A: 13 m vs B: 39 m; p = 0.024), but not in PFS (A: 3 m vs B: 7 m; p = 0.70). No differences were observed in the PD-L1 positive group. CONCLUSIONS A trend toward a greater response to ICIs was observed in the PFS and OS of patients with high expression of p53 by IHC (TP53 mutation), especially in the PD-L1 negative adenocarcinoma subgroup. These results will make it possible to make future modifications to the clinical guidelines of NSCLC according to the expression of p53.
Theoretical calculations and experimental verification for the pumping effect caused by the dynamic micro-tapered angle

The atomizer with micro cone apertures has advantages of ultra-fine atomized droplets, low power consumption and low temperature rise. The current research of this kind of atomizer mainly focuses on the performance and its application while there is less research of the principle of the atomization. Under the analysis of the dispenser and its micro-tapered aperture’s deformation, the volume changes during the deformation and vibration of the micro-tapered aperture on the dispenser are calculated by coordinate transformation. Based on the characters of the flow resistance in a cone aperture, it is found that the dynamic cone angle results from periodical changes of the volume of the micro-tapered aperture of the atomizer and this change drives one-way flows. Besides, an experimental atomization platform is established to measure the atomization rates with different resonance frequencies of the cone aperture atomizer. The atomization performances of cone aperture and straight aperture atomizers are also measured. The experimental results show the existence of the pumping effect of the dynamic tapered angle. This effect is usually observed in industries that require low dispersion and micro- and nanoscale grain sizes, such as during production of high-pressure nozzles and inhalation therapy. Strategies to minimize the pumping effect of the dynamic cone angle or improve future designs are important concerns. This research proposes that dynamic micro-tapered angle is an important cause of atomization of the atomizer with micro cone apertures.
Computing Schematic Layouts for Spatial Hypergraphs on Concentric Circles and Grids

Set systems can be visualized in various ways. An important distinction between techniques is whether the elements have a spatial location that is to be used for the visualization; for example, the elements are cities on a map. Strictly adhering to such location may severely limit the visualization and force overlay, intersections and other forms of clutter. On the other hand, completely ignoring the spatial dimension omits information and may hide spatial patterns in the data. We study layouts for set systems (or hypergraphs) in which spatial locations are displaced onto concentric circles or a grid, to obtain schematic set visualizations. We investigate the tractability of the underlying algorithmic problems adopting different optimization criteria (e.g. crossings or bends) for the layout structure, also known as the support of the hypergraph. Furthermore, we describe a simulated‐annealing approach to heuristically optimize a combination of such criteria. Using this method in computational experiments, we explore the trade‐offs and dependencies between criteria for computing high‐quality schematic set visualizations.
CHARGING OF SIO2 ELECTRET FILM BY ION IMPLANTATION FOR MEMS BASED ENERGY HARVESTING SYSTEMS

This paper presents results of charging SiO2 thin film electret by ion implantation. Maximum charge density of 16 mC/m 2 has been shown using 500 nm thermal oxide. Charge is reproducible and stable in time. Two types of ions were used for ion implantation: Phosphorus (P + ) and boron (B + ). It was found that charging with B + resulted in more stable surface potential than that of P + . SiO2 is a promising electret for energy harvesting, which can be charged in a reproducible and stable way by ion implantation. The results are used for the realization of a vibration based, capacitive energy harvester.
Impacts of Symptomatic HIV Infection on In-Hospital Cardiopulmonary Resuscitation Outcomes:  A Population-Based Cohort Study in South Korea

Abstract Background The impact of HIV infection on survival outcomes after in-hospital cardiopulmonary resuscitation (ICPR) remains controversial. This study aimed to investigate the impacts of HIV infection on both short-term and long-term outcomes after ICPR. Methods This nationwide, population-based cohort study used data taken from the South Korean National Health Insurance Service database. All adult (≥18 years old) patients who experienced ICPR between January 1, 2010, and December 31, 2019, were included. Results A total of 298 676 adult patients who underwent ICPR were initially included in the analysis. Among them, 586 (0.2%) patients were assigned to the patients with symptomatic HIV infection (PWH) group, while 298 090 (99.8%) patients were assigned to the control group. After 1:10 propensity score (PS) matching, 586 patients in the PWH group and 5845 patients in the control group were included in the analysis. Logistic regression analysis after PS matching showed that the PWH group had a 20% lower live discharge rate after ICPR compared with the control group (odds ratio, 0.80; 95% CI, 0.65–0.97; P = .024). However, Cox regression analysis after PS matching showed that the risks of 6-month survival (hazard ratio [HR], 1.01; 95% CI, 0.93–1.11; P = .768) and 1-year survival (HR, 1.02; 95% CI, 0.93–1.11; P = .702) were not significantly different between the PWH and control groups. Conclusions Although the PWH group showed lower live discharge rates compared with the control group after ICPR, long-term survival outcomes from 6 months and 1 year were not significantly different.
The line of fifths and the co-evolution of tonal pitch-classes

In this study, we determine the fundamental role of the line of fifths for the organization of tonal material by applying dimensionality reduction to a large historical corpus of pitch-class counts (ca. 1360–1940). We observe a historically growing trend in the exploitation of the fifths range, i.e. the size of segments that pitch-class distributions cover on the line of fifths. Moreover, we introduce the novel concept of pitch-class (co-)evolution, which traces the changing co-occurrence of pitch classes over time and likewise reaffirms the centrality of this linear tonal space from a historical angle, allowing us also to distinguish between historical periods in terms of the usage of pitch classes.
Synthesis, molecular modeling, and biomedical applications of oxovanadium(IV) complexes of Schiff bases as a good SARS-CoV-2 inhibitor

Abstract Oxovanadium(IV) complexes of dibasic symmetrical bis-Schiff bases synthesized from 1,6-hexanediamine and orthohydroxy aldehydes or diketones. Their formation was confirmed with the help of elemental analysis, FTIR, 1H NMR, UV-visible and mass spectra, magnetic susceptibility, and conductance measurements. Quantum mechanical calculations are indicative to the proposed structures of the complexes. Most of the ligands and complexes have considerable inhibition capacity on mycelia growth against selected pathogenic fungi and bacteria and show good antioxidant property too. Complexes showed good larvicidal activity against the mosquito larvae (Culex quinquefasciatus). Molecular docking of a Schiff base, (BzA-HD-BzAH2) with SARS-CoV-2 Mpro revealed the best binding affinity with the receptor protein compared to the approved medicine hydroxychloroquine (HCQ) and favipiravir (FVP). The ADMET analysis showed that ligand is non-carcinogenic and less toxic than standards, HCQ or FVP. However, these in silico studies proved BzA-HD-BzAH2 to be a good candidate for development as a therapeutic drug against SARS-CoV-2.
MINAT MAHASISWA MENGGUNAKAN SOFTWARE ACCOUNTING: EFEK DARI COMPUTER ANXIETY DAN COMPUTER ATTITUDE

Tujuan dari penelitian adalah untuk mengkaji pengaruh dari “computer anxiety” dan computer attitude akan keinginan mahasiswa akuntansi dalam pengunaan “software accounting”. Melalui pendekatan kuantitatif, penelitian ini menggunakan alat uji statistik PLS untuk menguji hipotesis. Sumber data primer diperoleh melalui penyebaran kuesioner secara langsung dan hasilnya diperoleh sebanyak 98 mahasiswa telah mengisi kuisioner. Desain penyampelan dilakukan melalui sampel random sampling dan penentuan jumlah sampel ditentukan dengan rumus slovin. Hasil penelitian menunjukkan bahwa computer anxiety dan computer attitude berpengaruh pada keinginan mahasiswa menggunakan accounting software. Mahasiswa telah mampu mengatasi kekhawatiran mereka dengan antusiasme mereka untuk terus belajar menggunakan perangkat lunak akuntansi dan membuat perubahan pada perilaku generasi calon akuntan yang kredibel dan mampu menghadapi era revolusi industri 4.0. Kata kunci: computer attitude; computer anxiety; software accounting; minat mahasiswa.
The 1126 Ma volcanic event in the Dechang Area, SW Yangtze Block, and its significance

Abstract Traditionally, the strata of the Luonie Valley, Dechang County, SW Sichuan, China, are considered to contain a suite of felsic volcanic rocks (the Huili Group) that erupted after c. 1050 Ma. However, we report here new age constraints, elemental and Lu–Hf isotope geochemistry for a different suite of older basaltic agglomerate lava, basaltic tuff lava and basalt from the same area, which we name the Luonie Formation. New dating results show that the basaltic volcanic suite of the upper part of the Luonie Formation formed at 1126.1 ± 9.9 Ma, significantly earlier than deposition of the Huili Group, but comparable in age to the 1142 ± 16 Ma Laowushan Formation in central Yunnan Province. Granite intrusion into the Luonie Formation dated 1050.7 ± 12.7 Ma provides crucial supporting evidence for this earlier depositional age. We also report a maximum sedimentary age of c. 1158 Ma for the underlying arkose, implying stratigraphic conformity with the basaltic volcanic rock suite. The ϵ Hf(t) values of the basaltic volcanic rocks are mainly positive, indicating that the rocks are mainly derived from the depleted mantle and slightly stained by crustal materials. The characteristics of P*, Nb* and Zr* anomalies also support this view. The distribution patterns of trace and rare earth elements indicate that the basaltic volcanic rocks formed in an extensional setting. The Zr/4–Y–2Nb and Th–Nb/16–Zr/117 discrimination diagrams also provide evidence for this understanding. Lithofacies analysis shows that basaltic volcanic wrocks with the characteristics of both continental and marine facies should be formed in a littoral–neritic environment. We propose here that the evidence is consistent with a phase of continental extension that preceded the convergence of the SW Yangtze Block to form part of Rodinia.
Cells and Their Immediate Progenitors Regulate BLyS Receptor Levels in Mature B Cutting Edge: B Cell Receptor Signals

This study examines how B lymphocyte stimulator (BLyS) receptor expression and responsiveness are influenced by B cell receptor (BcR) signaling. Our results show that resting and BcR-stimulated B cells are dependent on BLyS for survival and that B cells remain BLyS responsive during BcR-induced activation. Further, BcR ligation up-regu-lates expression of the BLySR B cell maturation defect/ BLySR3 (Bcmd/BR3), but not other known BLySRs. Fi-nally, the coupling of BcR signaling with Bcmd/BR3 expression is limited to late transitional and mature B cells. Together, these findings establish the coupling of BcR signaling with Bcmd/BR3 expression as a fundamental as-pect of follicular B cell selection, survival, and activation. The Journal of Immunology, 2003, 170: 5820–5823.
CSN Commentary Canadian Society of Nephrology Commentary on the 2012 KDIGO Clinical Practice Guideline for Acute Kidney Injury

Acute kidney injury (AKI) is associated with prolonged hospitalization, substantial health care resource consumption, high mortality, and can lead to progressive chronic kidney disease (CKD), including chronic kidney failure, in survivors. The Canadian Society of Nephrology (CSN) believes there is a need to develop clinical practice guidelines for patients with AKI; however, efforts to synthesize knowledge from clinical studies evaluating the prevention and treatment of AKI and to generate guidelines have been limited. One barrier has been the absence of consensus on the definition of AKI, with more than 35 definitions of AKI published to date. Further, there is a perceived lack of effective prophylactic and treatment strategies for AKI, and it is challenging to develop guidelines that involve multiple stakeholders from diverse disciplines including nephrology, critical care, and radiology, all of which are important end users of guidelines for AKI. In this context, the KDIGO (Kidney Disease: Improving Global Outcomes) AKI working group has recently published new criteria for the definition and classification of AKI, as well as a clinical practice guideline addressing both AKI prevention and treatment. The working group is part of KDIGO, which was established in 2003 with its stated mission to “improve the care and outcomes of kidney disease patients worldwide through promoting coordination, collaboration, and integration of initiatives to develop and implement clinical practice guidelines. ” The CSN applauds the efforts of KDIGO in evidence synthesis and development of global clinical practice guidelines, but also believes that local factors require consideration when making recommendations to guide care. Therefore, the CSN guidelines committee formed a work group to evaluate the KDIGO AKI guideline and its relevance to the Canadian context.
Auto-Cucumber: The Impact of Autocorrection Failures on Users’ Frustration

Many mobile users rely on autocorrection mechanisms during text entry on their smartphone. Previous studies investigated the effects of autocorrection mechanisms on typing speed and accuracy but did not explore the level of frustration and perceived mental workload often associated with autocorrection. Through a mixed-methods user study, we investigate the effect of autocorrection failures on increasing the user’s frustration, mental and physical demand, performance, and effort in this paper. We identified that perceived mental and physical demand, and frustration are directly affected by autocorrection.
Distributionally Robust Models with Parametric Likelihood Ratios

As machine learning models are deployed ever more broadly, it becomes increasingly important that they are not only able to perform well on their training distribution, but also yield accurate predictions when confronted with distribution shift. The Distributionally Robust Optimization (DRO) framework proposes to address this issue by training models to minimize their expected risk under a collection of distributions, to imitate test-time shifts. This is most commonly achieved by instance-level re-weighting of the training objective to emulate the likelihood ratio with possible test distributions, which allows for estimating their empirical risk via importance sampling (assuming that they are subpopulations of the training distribution). However, re-weighting schemes in the literature are usually limited due to the difficulty of keeping the optimization problem tractable and the complexity of enforcing normalization constraints. In this paper, we show that three simple ideas -- mini-batch level normalization, a KL penalty and simultaneous gradient updates -- allow us to train models with DRO using a broader class of parametric likelihood ratios. In a series of experiments on both image and text classification benchmarks, we find that models trained with the resulting parametric adversaries are consistently more robust to subpopulation shifts when compared to other DRO approaches, and that the method performs reliably well with little hyper-parameter tuning. Code to reproduce our experiments can be found at https://github.com/pmichel31415/P-DRO.
AEROBIC STABILITY AND QUALITY OF ELEPHANT GRASS SILAGES CONTAINING LEVELS OF RESIDUE OF AÇAÍ

The objective of this study is to evaluate the elephant grass silage with different levels of inclusion of açaí residue on the fermentative quality and aerobic stability. For this purpose 20 silos (SE) were made, 04 per treatment. The elephant grass and the residue of açaí berry were mixed at the time of the silage. The experimental design was completely in randomized design in five levels of inclusion, 0; 10; 20; 30 and 40% of industrial residue of açaí. The SE were opened in 30 days and samples were collected for bromatological analysis. The content of dry matter (DM) increased by 10.8% in 0 to 40% of silages of inclusion of the residue. At every 1% of added residue, organic matter content increased 0.063%. At temperatures of the silages there was linear reduction (P < 0.05) of 0.028% with the addition of the açaí residue of açaí. Silages with 20 and 30% of residue of açaí remained for a longer period within the ideal range of pH, 3.82 and 3.98 at 60 and 72 hours, respectively. Silages with 10, 20, 30, 40% presented the highest aerobic stability, because they reached 2° C elevation in relation to room temperature, with 12 hours of exposure to oxygen. However, the silage without inclusion of açaí residue remained stable for only 1 hour. All treatments with residue of açaí provided silages with sensory, fermentative features and MS content that tank them as having good quality, especially the treatment with 20% of açaí residue, as it presents the best results of the analyzed variables.
Islamic Banking and Finance Review

The concept of beneficial ownership has been used extensively in sovereign and quasi-sovereign ijārah ṣukūk structuring. This paper aims to examine the concept of beneficial ownership in the light of Islamic jurisprudence, common law and civil law systems. It overviews the laws related to beneficial ownership in the Pakistani, Bahraini, and Malaysian legal regimes. It further carries out the Sharīʿah appraisal of beneficial ownership focusing on its chief characteristics. The findings of this study posit that the legal status of ownership as per the Sharī‘ah is a need-based phenomenon and not a mandatory requirement. Hence, if a particular transaction complies with the ahkam (commands) for milkiyah and tamlikat (ownership), then transfer of ownership is a compulsory element for sale consequences. Moreover, it also explains that the use of beneficial ownership in sovereign and quasi-sovereign ijārah ṣukūk structures is acceptable in principle because the valid sale transaction that occurs transfers the ownership to the latter. Hence, it is described in ṣukūk prospectuses as ‘beneficial interest’. Finally, it may also be justifiable in the context of of ḥurīat al-taṣarruf (right to dispose-off the asset) and ‘qualified ownership’.