Miracle-dz/UniFAR-FTUs huggingface dataset:
SOME OF RISK FACTORS AND THEIR IMPACT ON STOMACH CANCER, OUR EXPERIENCE AND REVIEW OF LITERATURE

Stomach cancer is the second most common cause of cancer-related deaths in the world. The epidemiology of gastric cancer has changed in recent decades, there is a downward trend in its incidence levels, which as a result of the effect of increased standards of hygiene, adjustment of style or model and manner of nutrition, treatment of accuracy and negativity of Helicobacter pylori, which in plurals constitute the group of primary prevention of this pathology. However, the prevention of stomach cancer remains a priority for all health professionals who deal with the management of gastric pathologies. The most effective ways to treat gastric cancer are based on early detection, maintaining a balanced diet, moderate alcohol use, smoking cessation, body weight balance, NSAID use, without forgetting genetic predisposition or genetic predisposition previous stomach. Our objectives were: Evidence and detailed statistical description of risk factors of stomach cancer patients are included in this study were hospitalized in two clinical surgery medical centers in the period from January 2009 to January 2019, in University Clinical Center in Prishtina-Department of Surgery, Regional Hospital in Ferizaj-Department of Surgery. Material and methods: The study included 115 patients who met the criteria, and the Study variables were obtained from risk factor data that include: risk factor (Gender, Age, presence of Helicobacter pylori infection, Diet, Alcohol use, Tobacco use; Previous stomach surgery, Being overweight or obese, Some types of stomach polyps, Pernicious anemia… Conclusion: In relation to risk factors, we can confirm that, early detection of Gastric Cancer is vital in its primary prevention. Among the variable risk factors that favour the occurrence of stomach cancer and depend on the patient are; moderate alcohol intake, quitting smoking and maintaining a normal weight, maintaining a balanced diet; and those that depend on the medical treatment: Eradication of H. pylori, taking into account the correct treatment and reassessment for doubtful cases.
Allogeneic Hematopoietic Stem Cells Following Transplantation of Purified Rapid Reconstitution of Antibody Responses

Allogeneic hematopoietic cell transplantation has broad clinical applications extending from the treatment of malignancies to induction of immunologic tolerance. However, adaptive cellular and humoral immunity frequently remain impaired posttransplantation. Here, recovery of T-dependent and T-independent Ab responses was evaluated in mice transplanted with puriﬁed hematopoietic stem cells (HSCs) devoid of the mature immune cells believed to hasten immune recovery. Mixed and full donor chimeras were created by conditioning recipients with sublethal or lethal irradiation, respectively, across different donor/host genetic disparities. By 6 wk posttransplantation, all animals demonstrated robust T-independent Ab responses, and all mixed chimeras and recipients of MHC-matched or haploidentical HSCs with a shared MHC haplotype had T-dependent Ab responses equivalent to those of untransplanted controls. Full chimeras that received fully MHC-disparate HSCs showed delayed T-dependent Ab responses that recovered by 12 wk. This delayoccurred despite early reconstitution and proper migration to germinal centers of donor-derived T follicular helper (T FH ) cells. Congenic transplants into T FH -deﬁcient CD4 2 / 2 mice revealed restoration of T-dependent Ab responses by 6 wk, leading us to conclude that MHC disparity caused delay in humoral recovery. These ﬁndings, together with our previous studies, show that, contrary to the view that depletion of graft lymphocytes results in poor posttransplant immunity, elimination of immune-suppressing graft-versus-host reactions permits superior immune reconstitution. This study also provides insight into the regeneration of T FH cells and humoral immunity after allogeneic HSC transplantation. The Journal of Immunology , 2011, 186: 4191–4199. In this study, we examined Ab responses in transplantations of MHC-matched, haploidentical, and fully MHC-disparate puriﬁed HSC grafts in myeloablated and non-myeloablated recipients. We observed prompt recovery of Ab responses to both T-dependent and T-independent Ags when donor and recipients shared an MHC haplotype. In fully MHC-disparate chimeras, donor-derived T-dependent Ab responses were delayed despite early functional reconstitution of donor-derived T FH cells but recovered by 12 wk post-HSCT. comparison two controls, the lower signiﬁcance level is reported. Statistical analysis was performed using the Prism software package.
Traditional chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model cell infiltration, disruption of

Objective: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models. Materials and methods: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin–eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application. Results: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ. Conclusion: This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain–Barré syndrome.
Lignocellulosic Ethanol Biorefinery: Valorization of Lignin-Rich Stream through Hydrothermal Liquefaction

Hydrothermal liquefaction of lignin-rich stream from lignocellulosic ethanol production at an industrial scale was carried out in a custom-made batch test bench. Light and heavy fractions of the HTL biocrude were collected following an ad-hoc developed two-steps solvent extraction method. A full factorial design of experiment was performed, investigating the influence of temperature, time and biomass-to-water mass ratio (B/W) on product yields, biocrude elemental composition, molecular weight and carbon balance. Total biocrude yields ranged from 39.8% to 65.7% w/w. The Temperature was the main influencing parameter as regards the distribution between the light and heavy fractions of the produced biocrude: the highest amount of heavy biocrude was recovered at 300 °C, while at 350 and 370 °C the yield of the light fraction increased, reaching 41.7% w/w at 370 °C. Instead, the B/W ratio did not have a significant effect on light and heavy biocrude yields. Feedstock carbon content was mainly recovered in the biocrude (up to 77.6% w/w). The distribution between the light and heavy fractions followed the same trend as the yields. The typical aromatic structure of the lignin-rich stream was also observed in the biocrudes, indicating that mainly hydrolysis depolymerization occurred. The weight-average molecular weight of the total biocrude was strictly related to the process temperature, decreasing from 1146 at 300 °C to 565 g mol−1 at 370 °C.
Role of Helicobacter pylori infection in the development of perniciou s anaemia: a pilot s tu dy in primary care

Results: 2 (25%) of 8 PA-probands and 3 (37.5%) of 8 Ht-probands were H. pylori -positive. We found 7 PA-relatives with circulating anti- H. pylori antibodies (1 4%) and 3 Ht-relatives (6 %) (p= 0.3239 , ns). We found serological gastric body atrophy in one, 28-years old, female patient of the PA-relative group (2%), who did not show evidence of H. pylori -infection; in the control group no patient with serological gastric body atrophy was documented. The prevalence of PCAs in the PA-relative group was 6 % (3 subjects), vs 0% in the control group. O ne patient in the PA-relative group had both PCAs and antibodies to H. pylori (2%), whereas nobody in the control group showed this combination. Autoimmune-comorbidity was present in 6 PA-relatives and in none of the control group (p= 0.0277, s).
INVITED REVIEW METABOLIC AND MITOTIC CHANGES ASSOCIATED WITH THE FETAL ALCOHOL SYNDROME

— In the USA, fetal alcohol syndrome (FAS) is the leading known cause of mental retardation. FAS is estimated to affect 4000 infants yearly in the USA with an additional 7000 children suffering various forms of fetal alcohol effects in the absence of the full syndrome. A comparable incidence would be expected in other industrialized countries, but essentially no data are available from either developing or third world countries. An understanding of the biochemical causes of FAS has been slow to develop, but progress has been made toward a molecular causation theory of FAS. This paper summarizes much of the current work as to the effects of fetal ethanol exposure on mitotic and metabolic parameters as well as ethanol's effect on the cellular signalling pathways thought to regulate these processes. Based upon these studies, it is apparent that exposure of embryonic tissue to ethanol results in decreased growth and that alcohol adversely affects a multitude of cellular functions critical for the growth of the developing organism, including inhibition of protein and DNA synthesis. In addition, ethanol alters the uptake of critical nutrients such as glucose and amino acids and causes changes in several kinase-mediated signal transduction pathways that regulate these biochemical processes.
The Androgen Derivative 5 A -Androstane-3 B ,17 B -Diol Inhibits Prostate Cancer Cell Migration Through Activation of the Estrogen Receptor B Subtype

Prostate cancer growth depends, in its earlier stages, on androgens and is usually pharmacologically modulated with androgen blockade. However, androgen-ablation therapy may generate androgen-independent prostate cancer, often characterized by an increased invasiveness. We have found that the 5 A -reduced testosterone derivative, dihydrotestosterone (the most potent natural androgen) inhibits cell migration with an androgen receptor–independent mechanism. We have shown that the dihydrotestosterone metabolite 5 A -androstane-3 B ,17 B -diol (3 B -Adiol), a steroid which does not bind androgen receptors, but efficiently binds the estrogen receptor B (ER B ), exerts a potent inhibition of prostate cancer cell migration through the activation of the ER B signaling. Very surprisingly, estradiol is not active, suggesting the existence of different pathways for ER B activation in prostate cancer cells. Moreover, 3 B -Adiol, through ER B , induces the expression of E-cadherin, a protein known to be capable of blocking metastasis formation in breast and prostate cancer cells. The inhibitory effects of 3 B -Adiol on prostate cancer cell migration is counteracted by short interfering RNA against E-cadherin. Altogether, the data showed that ( a ) circulating testosterone may act with estrogenic effects downstream in the catabolic process present in the prostate, and ( b ) that the estrogenic effect of testosterone derivatives (ER B -dependent) results in the inhibition of cell migration, although it is apparently different from that linked to estradiol on the same receptor and may be protective against prostate cancer invasion and metastasis. These results also shed some light on clinical observations suggesting that alterations in genes coding for 3 B -hydroxysteroid dehydrogenases (the enzymes responsible for 3 B -Adiol formation) are strongly correlated with hereditary prostate cancer. (Cancer Res 2005; 65(12): 5445-53)
What-If Analysis: Antecedents and Consequences Factors of Counterfactual Thinking

The present study shows the relationship between counterfactual thinking and resilience, optimism, sense of coherence, hardiness, benign and malicious envy, rational and intuitive decision making, rumination. The sample for the study was 200 young adults (18-35 years). The assessment scales used for the present study were The Brief Resilience Scale (BRS), Sense of Coherence Scale(SoC), A Short Hardiness scale, The Benign and Malicious envy scale(BeMaS), Rumination Revised Scale(RSS), Decision Making Questionnaire(DMQ), Counterfactual Thought for Negative Events Scale (CTNES) and Life-Orientation Revised Scale(LOT-R). Correlation and regression analysis was done using SPSS(20.0) software. The findings of the study showed a significant inverse correlation between counterfactual thinking and optimism whereas a significant direct correlation was observed between counterfactual thinking and resilience, sense of coherence, hardiness, benign and malicious envy, rational and intuitive decision making and rumination. It was also found that rational and intuitive decision making and rumination were the best predictor of counterfactual thoughts respectively. Keyword: Counterfactual Thinking, Resilience, Optimism, Sense Of Coherence, Hardiness, Benign And Malicious Envy, Rational And Intuitive Decision Making and Rumination
FISH DIVERSITY IN TWO RESERVOIRS IN SOUTHWEST NIGERIA

This study investigated the fish diversity of Eko – Ende and Owalla reservoirs, which are within the Osun river system in South West, Nigeria with a view to document biodiversity information needed for conservation and sustainable fisheries. Fish samples were collected monthly from the two reservoirs for one year, using a battery of multifilament gill nets. The data collected from each reservoir was analyzed for fish diversity. Information obtained on the forage / carnivore (F/C) ratio of fishes in each reservoir was used in measuring and comparing the ecological balance of the reservoirs. The results showed that eighteen fish species representing 16 genera and 10 families were identified in Eko – Ende, while 17 fish species in 15 genera and 10 families were identified in Owalla during the period of study. Sixteen species (representing 84.2% of the total number of fish species)
Leukocyte Recruitment after Brain Injury Signaling through MyD88 Regulates

2 Injury to the CNS provokes an innate inﬂammatory reaction that engages inﬁltrating leukocytes with the capacity to repair and/or exacerbate tissue damage. The initial cues that orchestrate leukocyte entry remain poorly deﬁned. We have used ﬂow cytometry to investigate whether MyD88, an adaptor protein that transmits signals from TLRs and receptors for IL-1 and IL-18, regulates leukocyte inﬁltration into the stab-injured entorhinal cortex (EC) and into sites of axonal degeneration in the denervated hippocampus. We have previously established the kinetics of leukocyte entry into the denervated hippocampus. We now show that signiﬁcant leukocyte entry into the EC occurs within 3–12 h of stab injury. Whereas T cells showed small, gradual increases over 8 days, macrophage inﬁltration was pronounced and peaked within 12–24 h. MyD88 deﬁciency signiﬁcantly reduced macrophage and T cell recruitment to the stab-injured EC and the denervated hippocampus at 5 days post-injury. Whereas macrophage and T cell entry remained impaired into the denervated hippocampus of MyD88-deﬁcient mice at 8 days, leukocyte inﬁltration into the stab-injured EC was restored to levels observed in wild-type mice. Transcripts for TNF- (cid:1) , IL-1 (cid:2) , and CCL2, which increased > 50-fold after stab injury in C57BL/6 mice at the time of peak expression, were severely reduced in injured MyD88 knockout mice. Leukocyte recruitment and gene expression were unaffected in TLR2-deﬁcient or TLR4 mutant mice. No signiﬁcant differences in gene expression were observed in mice lacking IL-1R or IL-18R. These data show that MyD88-dependent signaling mediates proinﬂammatory gene expression
How Managerial Processes Influence Employee Job Satisfaction A Case Study within the Hotel Industry

This thesis is conducted in the context of the hotel industry. Every year, the hotel investigated in this thesis completes a job satisfaction survey. The survey is built upon several facets from which an overall job satisfaction is derived. The problem is that the survey has through time shown poor results, especially with facets concerning management. When those facets were summed up with other facets, it had a strong negative influence on the overall job satisfaction at Hotel X. Scarpello and Campbell (1983) argue that all facets may not directly influence overall job satisfaction, and as a consequence the sum of several facets might contribute to misleading conclusions. The purpose of this thesis is to investigate how managerial processes influence employees’ overall job satisfaction at Hotel X. By managerial processes is meant what managers do or is perceived by employees to do. The thesis investigates job satisfaction at both an overall and a facet level. Questions on which facets that influence overall job satisfaction, as well as whether managerial processes have a direct or indirect influence on overall job satisfaction are answered. In order to fulfil our purpose multiple sources of evidence were used. Surveys made by the hotel were used as secondary data. The primary data consisted of qualitative observations and in-depth interviews with employees. The facets investigated were; Job
SEMICONDUCTORS AND DIELECTRICS MECHANICAL MODIFICATION OF ELECTRONIC PROPERTIES OF ULTRATHIN 𝛽 -Ga 2 O 3 FILMS

Using the methods of the electronic density functional and pseudopotential theories, the spatial distributions of the valence electron density, the density of electronic states, and the gap widths in thin 𝛽 -Ga 2 O 3 films with various free surfaces subjected to mechanical compression are obtained from the first principles and using the author’s program code. It is shown that the thickness of the 𝛽 -Ga 2 O 3 films, the type of their free surface, and the mechanical action of compression allow the conductive properties of 𝛽 -Ga 2 O 3 thin films to be controlled.
Title: A functional variant in HTR7 , rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression

Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the results are difficult to replicate. Previous animal studies have shown that knockout of the serotonin receptor 7 ( HTR7 ) resulted in an antidepressant-like phenotype, suggesting it was important to antidepressant action. In this report, in the first stage, we used a cost-effective pooled-sequencing strategy to sequence the entire HTR7 gene to investigate the association of common variants in HTR7 and clinical response to four selective serotonin reuptake inhibitors (SSRIs) in a retrospective cohort mainly consisting of subjects with bipolar disorder. We found 80 SNPs with FDR < 0.05 associated with response to paroxetine, among which rs7905446 (T/G), located at the promoter region, also showed nominal significance in fluoxetine group. TG/GG genotypes for rs7905446 and female gender were associated with better response to two SSRIs (paroxetine and fluoxetine). In the second stage, we replicated this association in two independent prospective samples of SSRI-treated patients with major depressive disorder: the MARS ( P = 0.0169) and GENDEP studies ( P = 0.008). The TG/GG genotypes were consistently associated with response in all three samples. Functional study showed that the rs7905446-G allele interacted with CEBPB transcription factor, and displayed greater promoter activity in two neuronal-related cell lines while estrogen treatment decreased the activity of only the G allele. Our results provided novel pharmacogenomic evidence to support the role of HTR7 in association with antidepressant response. factors and treatment response may allow for the clinical implementation of pharmacogenetic tests and the development of personalized treatment in patients. Our study showed a functional SNP, rs7905446 in the HTR7 gene was associated with response to antidepressants in both bipolar and unipolar depression, which warrants further investigation as a potential novel pharmacogenetic diagnostic marker.
Metabolic synthetic lethality: a randomized, phase 0/I trial of the mitochondrial inhibitor ME-344 or placebo added to bevacizumab in early HER2-negative breast cancer.

Background: We previously demonstrated that mitochondrial inhibitors efficacy was restricted to a metabolic context in which mitochondrial respiration was the predominant energy source, a situation achievable by inducing vascular normalization/hypoxia correction with antiangiogenics. Vascular normalization can be tracked with FDG-PET. We tested the efficacy of the mitochondrial inhibitor ME-344 or placebo added to bevacizumab in early breast cancer. Methods: Treatment-naïve HER2-negative patients with T>1cm (any N) underwent a breast-centered FDG-PET (day 1) and received a single dose of bevacizumab (15 mg/kg), followed by a second FDG-PET (day 8). Patients were then randomized (1:1) to Arm A (ME-344 10 mg/kg intravenous on days 8, 15, and 21) or Arm B (placebo). Tumors were biopsied on days 0 and 29. Succinate dehydrogenase enzyme histochemistry (SDH-EHC), confocal microscopy of vessel architecture, and HIF-1 a staining were performed in pre-and post-treatment biopsies to assess the pharmacodynamics, vessel normalization, and tissue re-oxygenation by bevacizumab, respectively. Results: N=42 patients. ME-344 displayed significant biological activity versus placebo: compared with a 186% increase in Arm B, Ki67 decreased by 23.4% from days 0 to 28 in Arm A (P < 0.001). FDG-PET predicted vascular normalization in about one-third of the patients in each arm, which was confirmed using confocal microscopy and HIF-1 a staining. In the subgroup with vascular normalization, ME-344 induced a Ki67 decrease of 33.4% (placebo: 11.8 increase). SDH-EHC suggested on-target effects of ME-344. Conclusions: ME-344 has significant biological antitumor activity in HER2-negative breast cancer, particularly after induction of vascular normalization and tissue re-oxygenation with bevacizumab. the very low rate of methodological failure. Our results highlight the usefulness of phase 0 trials to search for specific