Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimal Conspicuity of Liver Metastases in Virtual Monochromatic Imaging Reconstructions on a Novel Photon-Counting Detector CT—Effect of keV Settings and BMI

In dual-energy CT datasets, the conspicuity of liver metastases can be enhanced by virtual monoenergetic imaging (VMI) reconstructions at low keV levels. Our study investigated whether this effect can be reproduced in photon-counting detector CT (PCD-CT) datasets. We analyzed 100 patients with liver metastases who had undergone contrast-enhanced CT of the abdomen on a PCD-CT (n = 50) or energy-integrating detector CT (EID-CT, single-energy mode, n = 50). PCD-VMI-reconstructions were performed at various keV levels. Identical regions of interest were positioned in metastases, normal liver, and other defined locations assessing image noise, tumor-to-liver ratio (TLR), and contrast-to-noise ratio (CNR). Patients were compared inter-individually. Subgroup analyses were performed according to BMI. On the PCD-CT, noise and CNR peaked at the low end of the keV spectrum. In comparison with the EID-CT, PCD-VMI-reconstructions exhibited lower image noise (at 70 keV) but higher CNR (for ≤70 keV), despite similar CTDIs. Comparing high- and low-BMI patients, CTDI-upregulation was more modest for the PCD-CT but still resulted in similar noise levels and preserved CNR, unlike the EID-CT. In conclusion, PCD-CT VMIs in oncologic patients demonstrated reduced image noise–compared to a standard EID-CT–and improved conspicuity of hypovascularized liver metastases at low keV values. Patients with higher BMIs especially benefited from constant image noise and preservation of lesion conspicuity, despite a more moderate upregulation of CTDI.
Investigating the Mechanical Property and Enhanced Mechanism of Modified Pisha Sandstone Geopolymer via Ion Exchange Solidification

The Yellow River has the highest sediment concentration in the world, and the Yellow River coarse sediment mainly comes from a particular kind of argillaceous sandstone, Pisha sandstone. This paper reports an investigation of the possibility of development of low-cost engineering materials using Pisha sandstone via ion exchange modification. The effect of modifiers with different concentration on the inhibition of volume expansion and the strength enhancement of modified Pisha sandstone were studied via ion exchange solidification. The effects of the concentration of ten types of modifier solutions and curing age were considered. The hydration of the mineral components, particle surface potential and reaction products were studied, respectively, by XRD, zeta potential, TG/DTG and SEM. Expansion volume and shear strength tests were conducted to assess the volume stability and mechanical property of modified Pisha sandstone. It showed that the expansion of Pisha sandstone was controlled and that the volume stability and shear strength were improved via ion exchange modification. The results of XRD, TG/DTG and SEM showed that the spacing of the crystal layers of the Pisha sandstone clay mineral and the mass lost had decreased significantly. When the concentration of the modifier was 0.05 mol/L, the volume reduced by 54.55% maximum and the shear strength reached the peak of 138 kPa.
The Influence of Different Rope Jumping Methods on Adolescents’ Lower Limb Biomechanics during the Ground-Contact Phase

As a simple and beneficial way of exercise, rope skipping is favored by the majority of teenagers, but incorrect rope skipping may lead to the risk of injury. In this study, 16 male adolescent subjects were tested for bounced jump skipping and alternating jump rope skipping. The kinematic data of the hip, knee, ankle and metatarsophalangeal joint of lower extremities and the kinetics data of lower extremity touching the ground during rope skipping were collected, respectively. Moreover, the electromyography (EMG) data of multiple muscles of the lower extremity were collected by Delsys wireless surface EMG tester. Results revealed that bounced jump (BJ) depicted a significantly smaller vertical ground reaction force (VGRF) than alternate jump (AJ) during the 11–82% of the ground-contact stage (p < 0.001), and the peak ground reaction force and average loading rate were significantly smaller than AJ. From the kinematic perspective, in the sagittal plane, when using BJ, the flexion angle of the hip joint was comparably larger at 12–76% of the ground-contact stage (p < 0.01) and the flexion angle of the knee joint was significantly larger at 13–72% of the ground-contact stage (p < 0.001). When using two rope skipping methods, the minimum dorsal extension angle of the metatarsophalangeal joint was more than 25°, and the maximum was even higher than 50°. In the frontal plane, when using AJ, the valgus angle of the knee joint was significantly larger during the whole ground-contact stage (p < 0.001), and the adduction angle of the metatarsophalangeal joint (MPJ) was significantly larger at 0–97% of the ground-contact stage (p = 0.001). EMG data showed that the standardized value of root mean square amplitude of the tibialis anterior and gastrocnemius lateral head of BJ was significantly higher than AJ. At the same time, that of semitendinosus and iliopsoas muscle was significantly lower. According to the above results, compared with AJ, teenagers receive less GRF and have a better landing buffer strategy to reduce load, and have less risk of injury during BJ. In addition, in BJ rope skipping, the lower limbs are more inclined to the calf muscle group force, while AJ is more inclined to the thigh muscle group force. We also found that in using two ways of rope skipping, the extreme metatarsophalangeal joint back extension angle could be a potential risk of injury for rope skipping.
Prevalence of Extended-Spectrum β-Lactamase Genes and Antibiotic Resistance Pattern in Clinical Isolates of Acinetobacter baumannii from Patients Hospitalized in Mashhad, Iran

Background: Carbapenem-resistant Acinetobacter baumannii strains are one of the most severe factors in hospital infection worldwide, in which the beta-lactamase enzyme is one of the main resistance mechanisms. Objectives: This study aimed to evaluate the presence of carbapenem-resistant beta-lactamase genes and determine antibiotic resistance patterns in the clinical isolates of A. baumannii from patients hospitalized in the Shahid Kamyab Hospital, Mashhad, Iran. Methods: Out of 286 collected isolates from patients hospitalized in Shahid Kamyab Hospital (from March 2017 to June 2017), 31 isolates were confirmed to be A. baumannii using biochemical tests. Antibiotic susceptibility testing was conducted using the disc diffusion method according to the CLSI standard protocols. The presence of beta-lactamase genes, namely blaVEB, blaPER, blaAmpC, blaVIM, blaIMP, blaSHV, and blaTEM, was detected using polymerase chain reaction. Results: In this study, 31 isolates were identified as Acinetobacter baumannii, all of which revealed high resistance to ceftazidime, cefixime, ceftriaxone, meropenem, imipenem, cefotaxime and cephalexin. In this case, the lowest resistance (19.35%) was observed against polymixin B. Moreover, blaAmpC, blaTEM, blaSHV, blaPER, and blaVIM were observed in 93.54% (29), 51.61% (16), 48.38% (15), 41.93% (13), and 77% (24) of the isolates, respectively. However, blaVEB and blaIMP were observed in none of the isolates. Conclusions: The results showed high carbapenem resistance and high frequency of beta-lactamase resistance genes among the clinical isolates of A. baumannii.
Application of Patient-Derived Cancer Organoids to Personalized Medicine

Cell models are indispensable for the research and development of cancer therapies. Cancer medications have evolved with the establishment of various cell models. Patient-derived cell lines are very useful for identifying characteristic phenotypes and susceptibilities to anticancer drugs as well as molecularly targeted therapies for tumors. However, conventional 2-dimensional (2D) cell cultures have several drawbacks in terms of engraftment rate and phenotypic changes during culture. The organoid is a recently developed in vitro model with cultured cells that form a three-dimensional structure in the extracellular matrix. Organoids have the capacity to self-renew and can organize themselves to resemble the original organ or tumor in terms of both structure and function. Patient-derived cancer organoids are more suitable for the investigation of cancer biology and clinical medicine than conventional 2D cell lines or patient-derived xenografts. With recent advances in genetic analysis technology, the genetic information of various tumors has been clarified, and personalized medicine based on genetic information has become clinically available. Here, we have reviewed the recent advances in the development and application of patient-derived cancer organoids in cancer biology studies and personalized medicine. We have focused on the potential of organoids as a platform for the identification and development of novel targeted medicines for pancreatobiliary cancer, which is the most intractable cancer.
The Effect of Investment Decision, Funding Decision, and Profitability on the Firm Value of Consumer Goods Industry Registered in Indonesia Stock Exchange During 2017-2020

This research was conducted to find out whether 1) investment decision can affect the firm value 2) funding decision can affect the firm value 3) profitability can affect the firm value 4) investment decision, funding decision, and profitability can affect the firm value simultaneously. The research observations were 92 companies from the sample of 23 consumer goods industries listed on the Indonesia Stock Exchange in 2017-2020 using the purposive sampling technique. The research method used is multiple regression analysis on panel data with a fixed-effect model and processed using the EViews 10.0 software. The result shows all three variables can affect the firm value simultaneously, investment decision has a positive and significant effect on the firm value, funding decision has a positive and significant effect on the firm value, and profitability has a positive and insignificant effect on the firm value.
The study of holmium substituted spinel ferrites for high frequency applications

The spinel ferrites are famous due to their unique electrical and magnetic performance. The current inspection is about the electrical and magnetic features of Holmium (Ho) substituted Co-Zn-ferrites (Co0.6Zn0.4Ho x Fe2−x O4; where x = 0.0 and 0.1). The Single-phase cubic configuration of prepared ferrites was perceived from X-ray diffraction data. The substituted sample has one order larger direct current (dc) resistivity as compared to the un-substituted sample. The substitution of Holmium decreased dielectric loss significantly. The dielectric study of samples was completed within the frequency range of 0.1–20 MHz. The comparison of dielectric parameters for different temperature values was measured. The magnetic characterization was done within the applied field of 2 kOe. The evaluated properties of samples like larger dc resistivity and less dielectric loss showed that the materials can be utilized in high-frequency applications.
Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons

To model α-Synuclein (αS) aggregation and neurodegeneration in Parkinson’s disease (PD), we established cultures of mouse midbrain dopamine (DA) neurons and chronically exposed them to fibrils 91 (F91) generated from recombinant human αS. We found that F91 have an exquisite propensity to seed the aggregation of endogenous αS in DA neurons when compared to other neurons in midbrain cultures. Until two weeks post-exposure, somal aggregation in DA neurons increased with F91 concentrations (0.01–0.75 μM) and the time elapsed since the initiation of seeding, with, however, no evidence of DA cell loss within this time interval. Neither toxin-induced mitochondrial deficits nor genetically induced loss of mitochondrial quality control mechanisms promoted F91-mediated αS aggregation or neurodegeneration under these conditions. Yet, a significant loss of DA neurons (~30%) was detectable three weeks after exposure to F91 (0.5 μM), i.e., at a time point where somal aggregation reached a plateau. This loss was preceded by early deficits in DA uptake. Unlike αS aggregation, the loss of DA neurons was prevented by treatment with GDNF, suggesting that αS aggregation in DA neurons may induce a form of cell death mimicking a state of trophic factor deprivation. Overall, our model system may be useful for exploring PD-related pathomechanisms and for testing molecules of therapeutic interest for this disorder.
Recent trends and future potential of microwave-assisted fish drying

Abstract Microwave (MW) offers a unique heating mechanism, which volumetrically pushes internal moisture to the surface during the drying of water-rich foods such as fish. However, due to the uneven power distribution, the continuous application of MW energy causes excessive localized heating, resulting in the deterioration of food quality. Incorporation of other drying techniques such as convective, vacuum, osmotic, and freeze-drying with MW has been attempted in the past to solve these shortcomings and applied in different drying systems. This paper investigates the current trends in microwave-assisted drying (MWAD) methods for fish. The available literature on MWAD methods is critically analyzed in terms of energy consumption and change in nutritional components as well as other properties. Additionally, this review explores the potential of MWAD methods for fish drying. This article shows that pulsed microwave convective drying (PMCD) can be implemented in fish drying effectively. Considering the critical need for improving energy efficiency and quality retention in fish drying, PMCD would be a highly promising drying method.
Atherosclerosis and Its Impact on the Outcomes of Patients with Deep Venous Thrombosis

Introduction: Atherosclerosis and pulmonary embolism (PE) affect cardiovascular mortality substantially. We aimed to investigate the impact of atherosclerosis on the outcomes of patients with deep venous thrombosis (DVT) and to identify the differences in DVT patients with and without PE. Methods: Patients with DVT with and without symptomatic atherosclerosis (defined as coronary artery disease, myocardial infarction and/or peripheral artery disease) as well as with and without PE under oral anticoagulation were enrolled during January 2011–April 2013 and compared. The impact of symptomatic atherosclerosis on several outcomes was analyzed. Results: Overall, 509 DVT patients (70.0 [56.0–77.0] years, 51.9% females) were included in this study. Among them, 179 (36.3%) had symptomatic atherosclerosis and 204 (40.1%) a concomitant PE. DVT patients with symptomatic atherosclerosis were older (74.0 [IQR 65.0–80.0] vs. 63.0 [48.0–75.0] years, p < 0.0001), more often male (56.4% vs. 43.9%, p = 0.0087) and had a higher prevalence of classical CVRF and a higher Charlson comorbidity index (7.00 [5.00–8.00] vs. 4.00 [2.00–6.00], p < 0.001). Symptomatic atherosclerosis was associated with increased mortality (HR 1.98 [95%CI 1.12–3.49], p = 0.018) and hospitalizations (HR 1.64 [95%CI 1.21–2.21], p = 0.0012) and primary long-term outcome (HR 1.99 [95%CI 1.31–3.04], p = 0.0013) during the 2 years follow-up-period in DVT patients. DVT patients without PE had diabetes mellitus (28.2% vs. 16.3%, p < 0.01) and symptomatic atherosclerosis (42.9% vs. 26.4%, p < 0.001) more often compared to DVT patients with PE, and symptomatic atherosclerosis was associated with isolated DVT (without PE) (OR 2.01 [95%CI 1.28–3.16], p < 0.01). Conclusions: Atherosclerosis was associated with isolated DVT (without PE) and increased mortality in DVT patients under oral anticoagulation. The profile of CVRF and comorbidities differed between DVT patients with and without a concomitant PE. In the case of DVT or PE, patients should be screened for concomitant atherosclerotic disease. Clinical Trial Registration: at clinicaltrials with Unique identifier NCT01809015.
Effects of propeller locations on the vortex system above delta-shaped UAV model

The flow above delta wing is complicated and dominated by a very complex vortex structure. This study investigates the effects of propeller locations on the aerodynamic characteristics above a 55° sharp-edged non-slender delta wing UAV model. The experiments were conducted in a closed circuit UTM-LST wind tunnel at speeds of 20 and 25 m/s. In this project the propeller is located at three different locations namely; front, middle and rear. The result obtained from this experiment was compared with the clean wing configuration. The effects of propeller locations, angle of attack, Reynolds number and propeller advance ratio on the aerodynamic characteristics of this generic UAV model are discussed in this paper. The experimental data highlights an impact of propeller locations on lift, drag, moment and vortex system of the UAV. The results also showed that the propeller advance ratio, J influence the vortex system above UAV wing.
Evaluating the effect of transport infrastructure on the employment in Vietnam

During the process of international economic integration, the labor issue plays a vital, urgent, and long-term role in the sustainable development of the economy. The impact of employment on a country's investment decisions is significant. The material underpinning of a nation's socio-economic growth is its transport infrastructure. The impact of infrastructure upgrades on employment in Vietnam's economic sectors is the focus of this article. Furthermore, the study investigates whether the Vietnamese government's annual investment in infrastructure development benefits employees as projected (using data from the Vietnam General Statistics Office (VNGSO) for 19 economic sectors from 2005 to 2019). The results of the System Generalized Method of Moments (System-GMM) show that improving the quality of transport infrastructure can significantly increase employment rates in different sectors. The data show that transport infrastructure plays a key role in ensuring smooth connectivity of the entire national, regional and local economies. It reduces transport costs and facilitates the mobility of workers.JEL Classification J8; L91; O18
CD133-Functionalized Gold Nanoparticles as a Carrier Platform for Telaglenastat (CB-839) against Tumor Stem Cells

The failure of a long-lasting curative therapeutic benefit of currently applied chemotherapies against malignant cancers is suggested to be caused by the ineffectiveness of such interventions on cancer stem cells (CSCs). CD133/AC133 is a cell surface protein previously shown to have potential to identify CSCs in various tumors, including brain tumors. Moreover, an increase in the rate of cellular metabolism of glutamine and glucose are contributors to the fast cellular proliferation of some high-grade malignancies. Inhibition of glutaminolysis by utilizing pharmacological inhibitors of the enzyme glutaminase 1 (GLS1) can be an effective anti-CSC strategy. In this study, the clinical-stage GLS1 inhibitor Telaglenastat (CB-839) was loaded into PEGylated gold nanoparticles equipped with the covalently conjugated CD133 aptamer (Au-PEG-CD133-CB-839) and exposed to a collection of CD133-positive brain tumor models in vitro. Our results show that Au-PEG-CD133-CB-839 significantly decreased the viability of CD133-postive cancer cells in a dose-dependent manner, which was higher as compared to the effects of treatment of the cells with the individual components of the assembled nanodrug. Interestingly, the treatment effect was observed in glioblastoma stem cells modeling different transcriptomic subtypes of the disease. The presented platform is the fundament for subsequent target specificity characterization and in vivo application.
The importance of continental evaporation for precipitation in Colombia: A baseline combining observations from stable isotopes and modelling moisture trajectories

The hydroclimatology of Northern South America responds to the coupling between the Pacific and Atlantic oceans, the Amazon–Andes interactions, and the orographic barrier of the regional Andes. The relative contributions of oceanic and terrestrial moisture sources have been mostly evaluated in modelling studies, with limited observational data for validation. We combine observations from stable isotopes in precipitation and output from the Lagrangian moisture trajectory tracking model FLEXPART to characterize and contrast the relative contribution of oceanic (from the Atlantic and the Pacific) and terrestrial (from different regions in the continent) moisture sources to mean monthly precipitation in the Andes and Caribbean regions of Colombia. Our results indicate that most moisture becoming rain in the region has an atmospheric residence time that deviates from commonly assumed 10 days. These residence times vary between source and sink regions from 1 day in the case of recycling to more than 10 days in Andean precipitation originating in the Atlantic Ocean. Common integration times for both regions from all sources are commonly in the order of three to 7 days. Most precipitation in the region comes from terrestrial sources including moisture recycling from the same region (>30% for all months), the Orinoco River basin (up to 28% in April), and the northern Amazon basin (up to 17% in June, July, and August); followed by individually considered oceanic sources including the Tropical South Pacific (up to 30% monthly in October, November and December) and Tropical North Atlantic (up to 30% monthly for January). The fact that a significant proportion of rainfall is recycled highlights that water availability in the Andean and Caribbean regions of Colombia could potentially be altered by current widespread and pervasive changes in vegetation cover. More generally, our results highlight the need to assess the hydrological consequences of land cover change in South America, particularly in a country like Colombia where water, food, and energy security all depend directly on precipitation.
‘Let them play’ the effect of active play on motor proficiency and social maturity of children

ABSTRACT Predominantly, childhood provides a window of opportunity for the promotion and development of social maturation and fundamental movement skills. The purpose of the study was to examine the effect of active play on the motor proficiency and social maturity of children. Thirty participants (age range: seven to nine years old) were randomly assigned to either an active play (n = 15) or a control (n = 15) groups. The intervention was 60 min/day, three days/week for four weeks for the active play group, while the control group did not participate in a specific training programme. All outcome variables (motor proficiency and social maturity) were measured twice (before and after the intervention). The significant results revealed that at the end of the intervention, the active play group showed improvement regarding outcome variables and had higher social maturity and motor proficiency, compared to the control group (p < .0001).