Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigation of Existing Researches for Seismic Fragility Assessment of Fuel Assembly in NPPs

The seismic safety of NPP(Nuclear Power Plants) is regarded as an important issue. After the Fukushima Daiichi nuclear accident in Japan (2011), as the earthquake consecutively occurred in Gyeongju (2016) and Pohang (2017) in South Korea, the concerns about earthquake has increased. To probabilistically evaluate the structural damage and risks caused by earthquake, the seismic fragility analysis, one of the major components of the PSA (Probabilistic Safety Assessment), is performed. The fragility analysis for various SSC (Structures, Systems and Components) of NPP was conducted, but for the FA (Fuel Assembly) isn't done yet. The FA is directly related to safety because it contains nuclear fuel in which fission occurs. Therefore, it is necessary to develop the methodology for evaluating seismic fragility of fuel assembly.
Degradation of Lithium fluoride thin targets on Carbon Backing Irradiated with 68 MeV 17O Beams at EMMA Facility of TRIUMF

An experiment was conducted to investigate the possible influence of a reaction on the astrophysical s process. To study the states dominating the 17O(α,)21Ne reaction rate indirectly, 7Li(17O,t)21Ne*()21Ne reaction was measured. 17O beam accelerated to 68 MeV at ISACII was impinged on a thin lithium fluoride (LiF) target on carbon backing for populating states in 21Ne through the 7Li(17O,t)21Ne reaction. In the experiment, failures caused by lattice damage caused by radiation in all the targets occurred during the beam running time. A study was conducted to analyze the cause of target destruction of the target so that the next same experiment could be conducted again efficiently with the prediction of target lifetime.
Promotional Effects of Al2O3 Addition to Co/SiO2 Catalysts for Fischer−Tropsch Synthesis

The addition of a small amount of Al 2 O 3 to silica-supported cobalt catalysts significantly increased the dispersion of cobalt and Co-metallic surface area, resulting in the remarkable enhancement of the Fischer-Tropsch synthesis (FTS) activity in the slurry-phase reaction. The addition of Al 2 O 3 adjusted the interaction between cobalt and the silica support quite well, realizing the favored dispersion and reduction degree of supported cobalt and leading to high catalytic activity in FTS. The properties of various catalysts were characterized by in situ DRIFT, XRD, TPR, N 2 physisorption, and H 2 chemisorption.
Impact Load Behaviour of Resin Transfer Moulding (RTM) Hemp Fibre Composite Laminates

Aim of this work is to determine experimentally some important mechanical characteristics of RTM hemp plain weave fabric/epoxy laminates. Equipment and test methods are described and critically discussed. Main subjects of this work are: RTM process improvement, preliminary tensile and f1exural tests and impact performance. The latter is analyzed with particular attention, also comparing data with other experimental results. Attention is devoted both to the process, which strongly influences the mechanical performance of natural long fibres reinforced composites and to the low-velocity impact behaviour. This is a very important requirement for future aeronautical applications, in that composite structures should retain sufficient residual compression properties (CAI: Compression After Impact) after a Barely Visible Impact Damage (B.V.I.D).
Subwavelength optical resonant cavity-induced enhancement of the near-band-edge emission from ZnO-core/SnO2-shell nanorods

ZnO-core/SnO2-shell nanorods were fabricated by a two-step process: thermal evaporation of ZnO powders and atomic layer deposition of SnO2. Transmission electron microscopy and X-ray diffraction revealed the cores and shells of the as-prepared core–shell nanorods to be single crystal wurtzite-type ZnO and polycrystalline rutile-type tetragonal SnO2, respectively. Photoluminescence (PL) measurements showed that the intensity of near-band edge (NBE) emission of ZnO nanorods was enhanced significantly by the SnO2 coating. The maximum intensity of NBE emission of the ZnO-core/SnO2-shell nanorods obtained with a shell layer thickness of 15 nm was ∼25 times higher than that of the ZnO nanorods. The enhancement of the NBE emission might be due to the combination of the following sources: the giant oscillator strength effect due to subwavelength optical resonant cavity formation in the nanorods, the quantum confinement of photogenerated carriers inside the ZnO cores, the suppression of visible emission and nonrad.
Relationship Between Patient Sex and Serum Tumor Necrosis Factor Antagonist Drug and Anti-Drug Antibody Concentrations in Inflammatory Bowel Disease; A Nationwide Study

Introduction: Anti-drug antibodies to infliximab (ATI) and adalimumab (ATA) are associated with loss of response to tumor necrosis factor antagonist (anti-TNF) therapy in inflammatory bowel disease (IBD). We evaluated the relationship between patient sex and serum TNF antagonist drug and antibody concentrations in inflammatory bowel disease. Methods: A nationwide multicenter retrospective cohort study was conducted by evaluating patient charts from July 2018 until February 2021. The effect of patient sex on anti-drug antibodies and serum drug concentration in patients with IBD across 7 hospitals was investigated. A subgroup analysis also investigated the effect of anti-TNF combination therapy. Results: In the total study sample (n = 1093), males receiving infliximab had higher anti-drug antibody concentrations (38.3 vs. 22.3 AU/ml; aRoGM = 1.72, 95% CI: 1.30-2.27, p-value <0.001) compared to females. Additionally, infliximab serum drug concentrations among males were lower compared to females (2.6 vs. 4.1 ug/ml; aRoGM = 0.62, 95% CI: 0.44-0.88, p-value = 0.007). In the subgroup analysis (n = 359), male compared to female patients on combination therapy with infliximab and immunomodulators had similar anti-drug antibody concentrations (30.2 vs. 21.9 AU/ml; aRoGM = 1.38, 95% CI: 0.79-2.40, p-value = 0.254). There was no difference in the anti-drug antibody and serum drug concentrations among males and females on adalimumab. Conclusion: In patients receiving infliximab, anti-drug antibodies were higher in males than females. Consistent with this, serum drug concentrations were lower in males than females on infliximab. However, there was no difference in anti-drug antibody and serum drug concentrations among males and females on adalimumab. In addition, no difference in anti-drug antibodies between males and females receiving anti-TNF combination therapy was observed.
The Occupation Behavior of Y2O3 and Its Effect on the Microstructure and Electric Properties in X7R Dielectrics

The occupation behavior of Y2O3 in nonreducible BaTiO3-based ceramics was investigated thoroughly. Based on XRD, SEM, TEM-EDS, and complex impedance analysis, it is ensured that there exists two turning points of Y2O3, 0.50 mol% and 1.00 mol%, and the latter is the solubility limit. Below 0.50 mol%, the introduced Y3+ ions precede to enter the A sites of the perovskite lattice, causing an observed enhancement in dielectric constant and energy storage density accompanied by an increase in grain size. Once the addition exceeds 0.50 mol%, the Y3+ ions will turn to occupy B sites to substitute for Ti4+ ions, leading to the significant reduction in dielectric constant and energy storage density. Above the solubility limit of 1.00 mol%, the excess Y3+ ions would segregate at grain boundary and even induce the formation of Y2Ti2O7 phase, resulting in an abrupt enhancement of grain-boundary resistance. Doped with 0.75–1.50 mol% Y2O3, all nonreducible specimens meet X7R requirement.
[Genotyping and sequence analysis on G2 segment of hantavirus carried by rat in Hebei province].

OBJECTIVE To know the genotype and subtype of hantavirus (HV) carried by host animals in HFRS natural epidemic area of Hebei province. METHODS According to the conservative sequence of 76-118 and R22 strains, specific primers were designed. RT-nested PCR was used to amplify partial M segments from the positive rat lungs screened by IFA. Agarose gel electrophoresis was used to identify the types. Nucleotides were assayed from partial products after purification and reclaim. Gene analysis was carried on with DNAStar package. RESULTS 32 specimens, which were positive screened by IFA, were amplified the specific segment (418bp) and all belonged to type SEO. Sequencing results of 10 partial segments indicated that G2 segment had little variability and nucleotide homology reached to 98.0%-100.0%. Comparing with the R22 and 76-118 strains, homology was 93.3%-94.3% and 67.7%-69.0% respectively. CONCLUSION According to G2 segment, SEO was the major type in Hebei HFRS natural epidemic area and S3 was the major subtype. HV which belonged to the same subtype had high homology and genetic materials were correspondingly stable. Different rats could carry the same subtype of HV.
Antimicrobial Peptides SLPI and Beta Defensin-1 in Sputum are Negatively Correlated with FEV1

Background Chronic obstructive pulmonary disease (COPD) and asthma have heterogeneous inflammation with inhaled corticosteroids (ICS) as a mainstay of treatment. There is increased prevalence of non-typeable Haemophilus influenzae (NTHi) persistence in airways of patients with neutrophilic airway inflammation, potentially due to suppressed host defence after corticosteroid treatment. Antimicrobial peptides (AMPs) have antimicrobial activity against pathogens and immunomodulatory effects. We investigated whether AMPs associate with NTHi presence in COPD and asthma, and whether ICS alter this. Methods Secretory leukocyte protease inhibitor (SLPI), osteopontin, elafin and beta defensin-1 were measured in sputum supernatants from healthy donors (n=9), asthmatics (n=21) and patients with COPD (n=14). Elafin and beta defensin-1 were measured in a primary human bronchial epithelial cells (HBECs) from healthy and COPD donors infected with NTHi and pre-treated with fluticasone propionate (FP) and budesonide (BUD). Internalised NTHi was quantified by qPCR. Results Sputum SLPI was negatively correlated with FEV1 (p<0.001, r=−0.610), FEV1% predicted (p<0.001, r=−0.583) and FEV1/FVC (p=0.001, r=−0.528). Sputum beta defensin-1 was negatively associated with FEV1 (p<0.001***r=−0.594). SLPI and beta defensin-1 levels in sputum were higher in the healthy controls and COPD group compared to the asthma group (p=0.001 and p=0.014) and (p<0.001 and p=0.007, respectively). ICS use was associated with higher sputum osteopontin compared to those with no ICS use. NTHi infection of COPD HBECs produced higher levels of beta defensin-1 compared to healthy donors (mean (SD) release: 45.1pg/mL (7.3) vs 21.2pg/mL (7.3) respectively, p=0.014). Elafin release from HBECs from COPD donors did not change following NTHi infection; however, elafin from healthy donors was significantly reduced (%mean reduction: 23.7%, 95% confidence intervals (CI) of reduction: 5.3–38.4%, p<0.01). Conclusion Sputum SLPI and beta defensin-1 may be markers to identify those patients with declining lung function. ICS use was associated with higher sputum osteopontin compared to those with no ICS use.
Rapid and simple single-chamber nucleic acid detection system prepared through nature-inspired surface engineering

Background: Nucleic acid (NA)-based diagnostics enable a rapid response to various diseases, but current techniques often require multiple labor-intensive steps, which is a major obstacle to successful translation to a clinical setting. Methods: We report on a surface-engineered single-chamber device for NA extraction and in situ amplification without sample transfer. Our system has two reaction sites: a NA extraction chamber whose surface is patterned with micropillars and a reaction chamber filled with reagents for in situ polymerase-based NA amplification. These two sites are integrated in a single microfluidic device; we applied plastic injection molding for cost-effective, mass-production of the designed device. The micropillars were chemically activated via a nature-inspired silica coating to possess a specific affinity to NA. Results: As a proof-of-concept, a colorimetric pH indicator was coupled to the on-chip analysis of NA for the rapid and convenient detection of pathogens. The NA enrichment efficiency was dependent on the lysate incubation time, as diffusion controls the NA contact with the engineered surface. We could detect down to 1×103 CFU by the naked eye within one hour of the total assay time. Conclusion: We anticipate that the surface engineering technique for NA enrichment could be easily integrated as a part of various types of microfluidic chips for rapid and convenient nucleic acid-based diagnostics.
Percutaneous ultrasound-guided plugged liver biopsy – a single-centre experience

Background Liver biopsy is a widely used, safe diagnostic tool utilised by clinicians for the histopathological assessment of the liver. Our study aims to report our experience in patients who underwent ultrasound-guided plugged percutaneous liver biopsy in a tertiary care hospital in India. Material and methods The Institutional Ethical Review Board approved this retrospective study, and informed consent was obtained from all the patients. A total of 830 liver biopsies were performed between January 2014 and December 2018, of which 782 were plugged percutaneous liver biopsies. The tract was plugged using Gelfoam slurry. Various observations related to the procedures were recorded. Results Seven hundred and eighty-two were plugged percutaneous liver biopsies, which were performed during the study period. Of the 782 patients, 163 were male, and 619 were female (20.8 % and 79.2 %, respectively), with a mean age of 49.6 ± 2 years (1 month to 86 years). A 100% technical success rate was seen. No immediate major complications were documented in any of the patients who underwent plugged biopsies. No significant complications were seen in any patient. Conclusions Percutaneous liver biopsy is an extensively performed diagnostic tool. We found that ultrasound-guided percutaneous plugged liver biopsy is an easy to perform procedure, which is associated with a lower risk of a bleeding complications.
Derivation of a Risk Assessment Tool for Prediction of Long-Term Pain Intensity Reduction After Physical Therapy

Rationale Risk assessment tools can improve clinical decision-making for individuals with musculoskeletal pain, but do not currently exist for predicting reduction of pain intensity as an outcome from physical therapy. Aims and Objective The objective of this study was to develop a tool that predicts failure to achieve a 50% pain intensity reduction by 1) determining the appropriate statistical model to inform the tool and 2) select the model that considers the tradeoff between clinical feasibility and statistical accuracy. Methods This was a retrospective, secondary data analysis of the Optimal Screening for Prediction of Referral and Outcome (OSPRO) cohort. Two hundred and seventy-nine individuals seeking physical therapy for neck, shoulder, back, or knee pain who completed 12-month follow-up were included. Two modeling approaches were taken: a longitudinal model included demographics, presence of previous episodes of pain, and regions of pain in addition to baseline and change in OSPRO Yellow Flag scores to 12 months; two comparison models included the same predictors but assessed only baseline and early change (4 weeks) scores. The primary outcome was failure to achieve a 50% reduction in pain intensity score at 12 months. We compared the area under the curve (AUC) to assess the performance of each candidate model and to determine which to inform the Personalized Pain Prediction (P3) risk assessment tool. Results The baseline only and early change models demonstrated lower accuracy (AUC=0.68 and 0.71, respectively) than the longitudinal model (0.79) but were within an acceptable predictive range. Therefore, both baseline and early change models were used to inform the P3 risk assessment tool. Conclusion The P3 tool provides physical therapists with a data-driven approach to identify patients who may be at risk for not achieving improvements in pain intensity following physical therapy.
Does dual-energy abdominal computed tomography increase the radiation dose to patients: a prospective observational study

Purpose The aim of our study was to compare single-energy (SECT) and dual-energy (DECT) abdominal computed tomography (CT) examinations in matched patient cohorts regarding the differences in effective radiation dose (ERD) and image quality performed in a third-generation dual-source computed tomography (DSCT) scanner. Material and methods Our study included 100 patients, who were divided randomly into 2 groups. The patients included in Group A were scanned by SECT, and Group B members were scanned by DECT. Volume CT dose index (CTDIvol), dose length product (DLP), and ERD for venous phase acquisition were recorded in each patient and were normalised for 40 cm. Analyses were performed by using statistical software (SPSS version 20.0 for windows), and Bonferroni correction for multiple comparisons was applied for p-values and confidence intervals. Results Average ERD based on DLP values normalised for 40 cm acquisition were obtained for both Group A and Group B. The mean ERD for Group A was 11.89 mSv, and for group B it was 6.87 mSv. There was a significant difference in these values between Group A and Group B as shown by a p-value of < 0.001. On subjective and objective analysis, there was no statistically significant difference in image quality between the 2 groups. Conclusions The protocols in third-generation DSCT using dual-energy mode resulted in significant reductions in the effective radiation dose (by approximately 58%) compared to SECT in routine abdominal examination in matched cohorts. Therefore, the quantitative imaging potential of DECT can be utilised in needed patients with decreased radiation dose in third-generation DSCT.
The Prognostic Role and Nomogram Establishment of a Novel Prognostic Score Combining with Fibrinogen and Albumin Levels in Patients with WHO Grade II/III Gliomas

Purpose World Health Organization (WHO) Grades II and III gliomas [also known as low grade gliomas (LGGs)] displayed different malignant behaviors and survival outcomes compared to Grade IV gliomas. This study aimed to identify the prognostic predictive value of a novel cumulative prognostic score [combined with fibrinogen and albumin levels (FA score)], establish and validate a point-based nomogram in LGG patients. Patients and Methods A total of 91 patients who underwent total glioma resection at Shengjing Hospital of China Medical University between 2011 and 2013 were enrolled to establish a prognostic nomogram. All patients were histologically diagnosed as grades II/III, and never received radiotherapy or chemotherapy before surgery. Data collection included patient characteristics, clinicopathological factors, and preoperative hematology results. The performance of the nomogram was subsequently validated by the concordance index (c-index), calibration curve, and receiver operating characteristic (ROC) curve. Results The FA score was negatively associated with the overall survival (OS) of LGG patients (p < 0.001). The results of multivariate analysis showed that FA score [p = 0.006, HR = 1.92, 95% confidence interval (CI): 1.21–3.05], age (p = 0.002, HR = 3.014, 95% CI:1.52–5.97), and white blood count (p < 0.001, HR = 4.24, 95% CI: 2.08–8.67) were independent prognostic factors for overall survival (OS). The study established a nomogram to predict OS with a c-index of 0.783 (95% CI, 0.72–0.84). Conclusion FA score might be a potential prognostic biomarker for LGG patients, and a reliable point-based nomogram will help clinicians to decide on the best treatment plans.
Pleural effusion secondary to chronic pancreatitis in childhood

Pleural effusion secondary to a pancreatico‐pleural fistula is a very rare presentation in children, with limited reports in the literature. We describe two differing presentations of pleural effusions resulting from chronic pancreatitis (CP) with successful resolution of the pleural effusion. These cases highlight the need for consideration of this rare paediatric diagnosis, and the variety of investigations, management strategies, and complications that can occur in the setting of CP in children.
Narrow-Band Reflectance Spectrophotometry for the Assessment of Erythematous and Hyperpigmented Skin Lesions in Localized Scleroderma: A Preliminary Study

Background Localized scleroderma (LoS) is an inflammatory fibrosing disease of the connective tissue, whose esthetic sequelae are atrophic skin lesions with hyperpigmentation. The key element of diagnostic and therapeutic procedures is the assessment of the disease's severity and damage. The study objective was to analyze the usefulness of narrow-band reflectance spectrophotometry (NBRS) to assess erythema and hyperpigmentation in LoS lesions. Materials and Methods Erythema indexes (EI) and melanin indexes (MI) were determined with the use of DermaLab Combo skin colour probe for LoS lesions and symmetrically located areas of normal skin. Then, relative percentage differences were determined for EI and MI, which were compared with the visual assessments of erythema and hyperpigmentation according to the Localized Scleroderma Cutaneous Assessment Tool (LoSCAT). Results A total of 84 LoS lesions were studied in 41 patients. The study showed a moderate correlations between the spectrophotometric measurements and clinical assessments of erythema as well as hyperpigmentation (Spearman correlation coefficient, r), r = 0.37; p = 0.00047 and r = 0.55; p=0.0000001, respectively. Conclusion NBRS seems to be a useful tool to assess the severity of erythema and hyperpigmentation in LoS lesions. Further studies are required in order to compare the spectrophotometric results with other objective methods.
2 J un 2 02 1 DISSECTING A RESONANCE WEDGE ON HETEROCLINIC BIFURCATIONS

This article studies routes to chaos occurring within a resonance wedge for a 3-parametric family of differential equations acting on a 3-sphere. Our starting point is an autonomous vector field whose flow exhibits a weakly attracting heteroclinic network made by two 1-dimensional connections and a 2-dimensional separatrix between two equilibria with different Morse indices. After changing the parameters, while keeping the 1-dimensional connections unaltered, we concentrate our study in the case where the 2-dimensional invariant manifolds of the equilibria do not intersect. We derive the first return map near the network and we reduce the analysis of the system to a 2-dimensional map on the cylinder. Complex dynamical features arise from a discretetime Bogdanov-Takens singularity, which may be seen as the organizing center by which one can obtain infinitely many attracting tori, strange attractors, infinitely many sinks and nontrivial contracting wandering domains. These dynamical phenomena occur within a structure that we call resonance wedge. As an application, we may see the “classical” Arnold tongue as a projection of a resonance wedge. The results are general, extend to other contexts and lead to a fine-tuning of the theory.