Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of COVID-19 on the Aviation Industry in Nigeria

This paper is a timely examination of the novel Corona Virus (Covid-19) that is currently ravaging the entire world. The main objective of this research is to study the impact of this global pandemic on the aviation sector in Nigeria. The methodology adopted is basically qualitative, explorative and analytical in nature, involving the use of secondary data via journal publications, government official documents, health authorities’ data and internet materials. This due to the fact that the virus is novel and very recent. The study found out that the Covid-19 pandemic has thrown the entire global economic, political and social systems into turmoil. The Nigerian economy and aviation sector in particular, has been in a meltdown, which had been thrown into a huge crisis. Some of the negative impacts of the scourge on the Nigerian aviation industry include closure of airports and banning of flights, increasing industry debt profile, negative impact on tourism, increased competitive pricing and severe loss of jobs. In terms of future prognosis, it will be quite a while before the sector recovers and whenever it re-opens, the most immediate visible change will be social distancing, touch less travel with passengers needing to be fit to travel. The turnaround time for local and international travels will increase as aircraft will be need to sanitize each time the planes land. Furthermore, there will be increased movement towards the digital space and most of the flight operations will be on digital platforms.
Influence of Hydrogen Peroxide (H 2 O 2 ) on Trichoderma harzianum Potentiality to Control Sunflower Root/collar Rot Pathogen Sclerotium rolfsii

n vitro studies showed significant inhibitory effects of hydrogen peroxide (H 2 O 2 ) on growth of either sunflower root/collar rot pathogen, Sclerotium rolfsii or the biocontrol agent Trichoderma harzianum . H 2 O 2 provided synergistic effects with T. harzianum, since the antagonistic potentiality of T. harzianum against S. rolfsii was increased with increasing H 2 O 2 concentration. Sunflower root/collar rot severity was significantly reduced when seeds were singly treated by H 2 O 2 or T. harzianum . H 2 O 2 appeared to be the most effective to prevent S. rolfsii infectivity followed by T. harzianum . The present study provided synergistic effects for H 2 O 2 to improve biocontrol capacity since H 2 O 2 at 1.2g/l with T. harzianum achieved sunflower protection by 78% against S. rolfsii infection.
The Relationship between Audit Committee Attributes and Audit Fees of Listed Companies in Nigeria

This paper examines the influence of audit committee (AC) attributes on audit fees (AUF) of 440 firm-year observations of listed companies in Nigeria for five year period (2012 to 2016). A multiple regression was employed in estimating the model using robust standard errors. We explore and improve prior literature of same relations by using additional variables (AC legal experts, AC stock ownership and AC chair independence). The study found that (AC size, AC financial accounting experts, AC legal experts and AC stock ownership) are positively associated with AUF in their quest for greater audit assurance. The study also established that female AC and AC chair independence act as substitute to audit quality which praises that higher internal control will be accredited to lower audit process. The findings and inferences are also consistent with complementary hypothesis of audit quality (payment of high fees in an exchange for better audit efforts. Our result is conclusive and robust for the inclusion of the foregoing AC attributes that were limitedly explored by prior studies in this relationship. Our study provides an insight on the importance of AC legal experts; AC stock ownership and AC chair independence to the current and potential stakeholders who are the direct users of financial reports. The study informs regulators and policy makers the potential influence of these unique AC attributes on auditors’ price which is one of the most crucial drivers of audit quality accredited to lower audit process. Our findings and inferences are also consistent with complementary hypothesis of audit quality (payment of high fees in an exchange for better audit efforts). Our result is conclusive and robust for the inclusion of the foregoing AC attributes that were limitedly explored by prior studies in this relationship. Our study provides an insight on the importance of AC legal experts, AC stock ownership and AC chair independence to the current and potential stakeholders who are the direct users of financial reports. The inferences will enable the investors better recognize the consequences of each variable in augmenting the credibility of financial disclosure which in turn enhance investors’ confidence. This study also informs the regulators by making them better understand the underlying importance of distinct AC attributes in enhancing audit quality which is one of the most pivotal driver of firms’ financial reporting quality. Specifically, these findings provide the regulators and policy makers the potential influence of AC legal experts, AC shareholdings, AC tenure and AC chair independence on auditors’ price which is one of the most crucial drivers of audit quality.
RAD51 135G>C Polymorphism and Cancer Risk: An Updated Meta-Analysis Involving 54,239 Subjects

The RAD51 plays a pivotal role in homologous recombination repair of DNA double-strand breaks inducing chromosomal breaks and genomic instability. Previous studies yielded conflicting results for the association between RAD51 135G>C polymorphism and risk of cancer. The present study aimed at investigating the pooled association using a meta-analysis on the published studies, involving 27,895 cases and 26,344 controls to assess the effect of RAD51 135G>C on cancer susceptibility. Across all populations, our results indicated that significant associations were found between RAD51 135G>C polymorphism and risk of cancer under genotypic C allele vs. G allele (OR =1.36 95% CI: 1.31-1.41), CC vs. GG (OR =2.37 95% CI: 2.12-2.65), CC vs. CG (OR =4.02 95% CI: 3.62-4.46), recessive model (OR =3.74, 95% CI: 3.40-4.11), and dominant model (OR =1.08, 95% CI: 1.03-1.13). In subgroup analyses, similar associations were found among Caucasians but not Asians. Moreover, the significant associations were found in subgroups of breast cancer, hematologic malignances, colorectal cancer, endometrial cancer, and ovarian cancer. This meta-analysis suggests that the RAD51 135G>C polymorphism was associated with susceptibility of cancer. The effect of the variants on the expression levels and the possible functional role of the variants in cancer should be addressed in further studies.
Can geostrophic adjustment of baroclinic disturbances in tropical atmosphere 1 explain MJO events? 2

Using the two-layer moist-convective rotating shallow water model, we study the process of relaxation (adjustment) of localized large-scale pressure anomalies in the lower equatorial troposphere, and show that it engenders coherent structures strongly resembling the Madden Julian Oscillation (MJO) events, as seen in vorticity, pressure, and moisture ﬁelds. We demonstrate that baroclinicity and moist convection substantially change the scenario of the quasi-barotropic “dry” adjustment, which was established in the framework of one-layer shallow water model and consists, in the long-wave sector, in the emission of equatorial Rossby waves, with dipolar meridional structure, to the West, and of equatorial Kelvin waves, to the East. If moist convection is strong enough, a dipolar cyclonic structure, which appears in the process of adjustment as a Rossby-wave response to the perturbation, transforms into a coherent modon-like structure in the lower layer, which couples with a baroclinic Kelvin wave through a zone of enhanced convection and produces, at initial stages of the process, a self-sustained slowly eastward-propagating zonally- dissymmetrical quadrupolar vorticity pattern. At the same time, a weaker quadrupolar structure of opposite sign arises in the upper layer, the whole picture similar to the active phase of the MJO events. The baroclinic Kelvin wave then detaches from the dipole, which keeps slow eastward motion, and circumnavigates the Equator, catching up and interacting with the dipole.
Protein Value of Vigna sinensis Seed: Comparison with Soybean-Oil Meal 1

The seeds of legumes are high in crude protein content (20 to 40 percent according to Morrison) (13), providing an important source of protein in human and animal nutrition particularly in tropical regions (2). Their lysine content is generally high (5 to 8 g/16 g N) (4,6,7,21). However, their protein value is limited; first, by an important sulphur amino acid deficiency (1.2 to 3.0 g/16 g N); second, by the presence in some of these seeds of thermolabile toxic factors, the nature of which is not too well known (3,10,14). Among the legumes which can be cultivated in the French West Indies, Vigna sinensis is of special interest because of its dry-seed yield (5), its high protein content (24 percent) and because it is easy to store (17). Its utilization in animal nutrition might bring about a reduction of protein importation. The present experiment was designed to determine the nutritive value of the proteins of Vigna sinensis as compared with those of soybean-oil meal on the basis of various tests conducted on the growth, digestibility and nitrogen retention of the white rat. The effects of a synthetic DL-methionine supplementation and of the heat treatment (autoclaving) of the seeds were also studied.
Title Page Title: Affective interoceptive inference: Evidence from heart-beat evoked brain potentials Running Title: Affective interoceptive inference Authors and Primary Affiliations:

The perception of internal bodily signals (interoception) is central to many theories of emotion and embodied cognition. According to recent theoretical views, the sensory processing of visceral signals such as one’s own heartbeat is determined by topdown predictions about the expected interoceptive state of the body (interoceptive inference). In this EEG study we examined neural responses to heartbeats following expected and unexpected emotional stimuli. We used a modified stimulus repetition task in which pairs of facial expressions were presented with repeating or alternating emotional content, and we manipulated the emotional valence and the likelihood of stimulus repetition. We found that affective predictions of external socially relevant information modulated the heartbeat-evoked potential, a marker of cardiac interoception. Crucially, the HEP changes highly relied on the expected emotional content of the facial expression. Thus, expected negative faces led to a decreased HEP amplitude, whereas such an effect was not observed after an expected neutral face. These results suggest that valence-specific affective predictions, and their uniquely associated predicted bodily sensory state, can reduce or amplify cardiac interoceptive responses. In addition, the affective repetition effects were dependent on repetition probability, highlighting the influence of top-down exteroceptive predictions on interoception. Our results are in line with recent models of interoception supporting the idea that predicted bodily states influence sensory processing of salient external information.
Supersubstorms (SML

We study extremely intense substorms with SuperMAG AL (SML) peak intensities < (cid:1) 2500nT ( “ supersubstorms ” /SSSs) for the period from 1981 to 2012. The SSS events were often found to be isolated SML peaks and not statistical ﬂ uctuations of the indices. The SSSs occur during all phases of the solar cycle with the highest occurrence (3.8year (cid:1) 1 ) in the descending phase. The SSSs exhibited an annual variation with equinoctial maximum altering between spring in solar cycle 22 and fall in solar cycle 23. The occurrence rate and strength of the SSSs did not show any strong relationship with the intensity of the associated geomagnetic storms. All SSS events were associated with strong southward interplanetary magnetic ﬁ eld B s component. The B s ﬁ elds were part of interplanetary magnetic clouds in 46% and of interplanetary sheath ﬁ elds in 54% of the cases. About 77% of the SSSs were associated with small regions of very high density solar wind plasma parcels or pressure pulses impinging upon the magnetosphere. Comments on how SSS events may cause power outages at Earth are discussed at the end of the paper. ed and analyzed using measurements from the SuperMAG network of magnetometers.
The RNA Binding Protein Tudor-SN Is Essential for Stress Tolerance and Stabilizes Levels of Stress-Responsive mRNAs Encoding Secreted Proteins in Arabidopsis

Tudor-SN (TSN) copuriﬁes with the RNA-induced silencing complex in animal cells where, among other functions, it is thought to act on mRNA stability via the degradation of speciﬁc dsRNA templates. In plants, TSN has been identiﬁed biochemically as a cytoskeleton-associated RNA binding activity. In eukaryotes, it has recently been identiﬁed as a conserved primary target of programmed cell death–associated proteolysis. We have investigated the physiological role of TSN by isolating null mutations for two homologous genes in Arabidopsis thaliana . The double mutant tsn1 tsn2 displays only mild growth phenotypes under nonstress conditions, but germination, growth, and survival are severely affected under high salinity stress. Either TSN1 or TSN2 alone can complement the double mutant, indicating their functional redundancy. TSN accumulates heterogeneously in the cytosol and relocates transiently to a diffuse pattern in response to salt stress. Unexpectedly, stress-regulated mRNAs encoding secreted proteins are signiﬁcantly enriched among the transcripts that are underrepresented in tsn1 tsn2 . Our data also reveal that TSN is important for RNA stability of its targets. These ﬁndings show that TSN is essential for stress tolerance in plants and implicate TSN in new, potentially conserved mechanisms acting on mRNAs entering the secretory pathway.
Identification of novel response and predictive biomarkers to Hsp90 inhibitors through mass spectrometry-based proteomic profiling of patient-derived prostate tumor explants

Identification of novel response and predictive biomarkers to Hsp90 inhibitors through mass spectrometry-based proteomic profiling of patient-derived prostate tumor explants Elizabeth V. Nguyen, Margaret M. Centenera, Max Moldovan, Rajdeep Das, Swati Irani, Andrew D. Vincent, Howard Chan, Lisa G. Horvath, David J. Lynn, Roger J. Daly, Lisa M. Butler 1. Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia 2. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia 3. Adelaide Medical School and Freemasons Foundation Centre for Men’s Health, University of Adelaide, Adelaide, South Australia 5005, Australia 4. South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia 5. Cancer Division, The Kinghorn Cancer Centre/Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia 6. Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia 7. Department of Medical Oncology, Chris O’Brien Lifehouse, Camperdown, New South Wales 2050, Australia 8. School of Medicine, Flinders University, Bedford Park, SA 5042, Australia.
Integrated Network Pharmacology Analysis and Experimental Validation to Reveal the Mechanism of Anti-Insulin Resistance Effects of Moringa oleifera Seeds

Background and Purpose: Insulin resistance (IR) is one of the factors that results in metabolic syndrome, type 2 diabetes mellitus and different aspects of cardiovascular dis-eases. Moringa oleifera seeds (MOS), traditionally used as an antidiabetic food and traditional medicine in tropical Asia and Africa, have exhibited potential effects in improving IR. To systematically explore the pharmacological mechanism of the anti-IR effects of MOS, we adopted a network pharmacology approach at the molecular level. Methods: By incorporating compound screening and target prediction, a feasible com-pound-target-pathway network pharmacology model was established to systematically predict the potential active components and mechanisms of the anti-IR effects of MOS. Biological methods were then used to verify the results of the network pharmacology analysis. Results: Our comprehensive systematic approach successfully identified 32 bioactive compounds in MOS and 44 potential targets of these compounds related to IR, as well as 37 potential pathways related to IR. Moreover, the network pharmacology analysis revealed that glycosidic isothiocyanates and glycosidic benzylamines were the major active components that improved IR by acting on key targets, such as SRC, PTPN1, and CASP3, which were involved in inflammatory responses and insulin-related pathways. Further biological research demonstrated that the anti-IR effects of MOS were mediated by increasing glucose uptake and modulating the expression of SRC and PTPN1. Conclusion: Our study successfully predicts the active ingredients and potential targets of MOS for improving IR and helps to illustrate mechanism of action at a systemic level. This study not only provides new insights into the chemical basis and pharmacology of MOS but also demonstrates a feasible method for discovering potential drugs from traditional medicines.
Human Age and Gender Classification using Convolutional Neural Networks

In a world relying ever more on human classification, this papers aims to improve on age and gender image classification through the use of Convolutional Neural Networks (CNN). Age and gender classification has become a popular area of study in the past number of years however there are still improvements to be made, particularly in the area of age classification. This research paper aims to test the currently accepted fact that CNN models are the superior model type for image classification by comparing CNN performance against Support Vector Machine performance on the same dataset. Using the Adience image classification dataset, this research also focuses on the implementation of data augmentation techniques, some more novel than others, as a means of improving CNN performance. In terms of standard popular methods of augmentation, image mirroring and image rotation were applied. As well as these, a more novel approach to augmentation was applied to the area of age classification. This technique was completed using Faceapp, an AI image editor in the form of a mobile application. This application allows for the placement of ”filters” on images of human beings in order to alter their appearance. The results of the data augmented models were superior to that of the standard CNN models with gender classification improving by 2.6% while age classification improved by 7.1%. The results of this research establish the potential for further improvements through the inclusion of more augmentation techniques or through the use of more filter types provided in the Faceapp application.
Identi�cation of drugs targeting multiple viral and human proteins using computational analysis for repurposing against COVID-19

The SARS-CoV2 is a highly contagious pathogen that causes COVID-19 disease. It has affected millions of people globally with an average lethality of ~3%. Unfortunately, there is no standard cure for the disease, although some drugs are under clinical trial. Thus, there is an urgent need of drugs for the treatment of COVID-19. In the current studies, we have used state of the art bioinformatics techniques to screen the FDA approved drugs against nine SARS-CoV2 proteins to identify drugs for quick repurposing. The strategy was to identify potential drugs that can target multiple viral proteins simultaneously. Additionally, we analyzed if the identi�ed molecules can also affect the human proteins whose expression is differentially modulated during SARS-CoV2 infection. The differentially expressed genes (DEGs) as a result of SARS-CoV2 infection were identi�ed using NCBI-GEO data (GEO-ID: GSE-147507). Targeting such genes may also be a bene�cial strategy to curb disease manifestation. We have identi�ed 74 molecules that can bind to various SARS-CoV2 and human host proteins. Their possible use in COVID-19 have also been reviewed in detail. We hope that this study will help development of multipotent drugs, simultaneously targeting the viral and host proteins, for the treatment of COVID-19.
Lymphatic filariasis in Some Wards in Bodinga Local Government Area of Sokoto State, Nigeria

The National Lymphatic Filariasis Elimination Programme (NLFEP) is committed to eradicate the lymphatic filariasis (LF) from Nigeria. Succeeding in this programme requires the availability of information on the distribution and nature of the disease from different parts of the country. Unfortunately, this is still not readily available. In this light, epidemiological study was carried out in five (5) wards in Bodinga Local Government Area of Sokoto State using Onsite Filariasis IgG/IgM Combo Rapid Test specific for Wuchereria bancrofti and Brugia malayi and search for clinical manifestations (hydrocele and lymphoedema). Out of the Two Hundred and Twenty-nine (229) individuals analysed, twenty-three (23) tested positive and this represents a prevalence of 10.0%. Infection rate was highest in Bangi/Dagaba ward with 13.3%. The males were more infected than the females; however, the difference is not statistically significant (P>0.05%). The age bracket 70 and above showed the highest rate of infection, 18.2%. The unmarried individuals were significantly more infected than the married ones (P<0.05). No clinical sign was observed in the study area. Mass drug administration is recommended for these wards since the prevalence rate is above 1% and this could enhance the achievement of the goal of eradicating the disease from the country.
Functional analysis of c -carotene ketolase involved in the carotenoid biosynthesis of Deinococcusradiodurans

Deinococcus radiodurans strain R1 synthesizes a unique ketocarotenoid product named deinoxanthin. The detailed steps involved in the biosynthesis of deinoxanthin remain unresolved. A carotene ketolase homologue encoded by dr0093 was inactivated by gene mutation to verify its function in the native host D. radiodurans . Analysis of the carotenoids in the resultant mutant R1 D crtO demonstrated that dr0093 encodes g -carotene ketolase (CrtO) catalysing the introduction of one keto group into the C-4 position of g -carotene derivatives to form ketolated carotenoids. The mutant R1 D crtO became more sensitive to H 2 O 2 treatment than the wild-type strain R1, indicating that the C-4 keto group is important for the antioxidant activity of carotenoids in D. radiodurans . Carotenoid extracts from mutant R1 D crtO exhibited lower 2,2-diphenyl-1-picrylhydrazyl radical-scaven-ging activity than those from the wild-type strain R1. The enhanced antioxidant ability of ketocarotenoids in D. radiodurans might be attributed to its extended conjugated double bonds and relative stability by the C-4 keto group substitution. the activity of the in