Miracle-dz/UniFAR-FTUs huggingface dataset:
Diet Changes and Underlying Motives in Cancer Patients

Abstract With rising cancer incidence rates and numbers of long-term cancer survivors, diet increasingly comes into view of patients as well as healthcare providers. The aim was to analyze cancer patients’ concepts of nutrition, changes in diet and reasons for these changes. This study is a cross-sectional single-center study. Data was collected 12/2017 − 01/2019 using a questionnaire. The study was set at an outpatient department at a German university hospital. 102 patients (male n = 47, female n = 54; age 34 to 86 years [mean = 62.3]) with cancer were included in the study. Statistical calculation was performed with Mann-Whitney-U-Test and Wilcoxon-signed-rank. p < 0.05 was considered significant. Patients were more concerned with diet after their diagnosis than before (p < 0.01). Seventy-one (70%) patients reported that they changed their diet or planned to do so. Some changes included an increased intake of vegetables or fruits. Patients who changed their diet more often were convinced that there was a positive influence of diet on the course of cancer (p < 0.05). Diet is an important topic for many cancer patients. Some patients seem to have a lack of information regarding the effect of diet on health. Physicians and dietitians should provide more education on healthy and safe diets for cancer patients.
Income, environmental considerations, and sustainable energy consumption in Africa

ABSTRACT Evidence on income as a crucial driver of renewable energy consumption in Africa is mixed. But hydropower accounts for over 90% of renewable energy in sub-Sahara Africa alone. Yet, empirical evidence suggests that hydropower may not be as environmentally sustainable as believed and, as a legacy source of energy in Africa, may not accurately reflect attitudes on renewable energy motivated by environmental concerns. This paper examines the role played by economic performance in the rising sustainable energy consumption in Africa, focusing on the renewable energy sources that are compatible with sustainable development. The difference generalized method of moments, fully modified ordinary least squares, and dynamic ordinary least squares are employed to estimate the statistical significance of income, environmental sustainability proxy, and prices as important drivers of sustainable energy consumption in a panel of 10 African countries for the period 2000–2011—a time frame characterized by a rapid rise in renewables as a priority in environmental policy. With timing and measurement considerations on sources of renewables, results indicate that in contrast to recent literature, the rise in sustainable energy consumption in Africa is strongly driven by rising domestic incomes. In line with literature, however, there is a generally positive, albeit statistically insignificant relationship between sustainable energy consumption and levels of carbon emissions. Oil prices in real terms also correlate with sustainable energy consumption. Available data also show that countries with low energy security also coincidentally tend to have high small hydropower capacity, providing potential for sustainably reducing energy insecurity.
Mitonuclear interactions and introgression genomics of macaque monkeys (Macaca) highlight the influence of behaviour on genome evolution

In most macaques, females are philopatric and males migrate from their natal ranges, which results in pronounced divergence of mitochondrial genomes within and among species. We therefore predicted that some nuclear genes would have to acquire compensatory mutations to preserve compatibility with diverged interaction partners from the mitochondria. We additionally expected that these sex-differences would have distinctive effects on gene flow in the X and autosomes. Using new genomic data from 29 individuals from eight species of Southeast Asian macaque, we identified evidence of natural selection associated with mitonuclear interactions, including extreme outliers of interspecies differentiation and metrics of positive selection, low intraspecies polymorphism and atypically long runs of homozygosity associated with nuclear-encoded genes that interact with mitochondria-encoded genes. In one individual with introgressed mitochondria, we detected a small but significant enrichment of autosomal introgression blocks from the source species of her mitochondria that contained genes which interact with mitochondria-encoded loci. Our analyses also demonstrate that sex-specific demography sculpts genetic exchange across multiple species boundaries. These findings show that behaviour can have profound but indirect effects on genome evolution by influencing how interacting components of different genomic compartments (mitochondria, the autosomes and the sex chromosomes) move through time and space.
Intrinsically disordered proteins: modes of binding with emphasis on disordered domains

Our notions of protein function have long been determined by the protein structure–function paradigm. However, the idea that protein function is dictated by a prerequisite complementarity of shapes at the binding interface is becoming increasingly challenged. Interactions involving intrinsically disordered proteins (IDPs) have indicated a significant degree of disorder present in the bound state, ranging from static disorder to complete disorder, termed ‘random fuzziness’. This review assesses the anatomy of an IDP and relates how its intrinsic properties permit promiscuity and allow for the various modes of interaction. Furthermore, a mechanistic overview of the types of disordered domains is detailed, while also relating to a recent example and the kinetic and thermodynamic principles governing its formation.
Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis

The epidermal growth factor receptor (EGFR) is an essential driver of oncogenic signalling, and EGFR inhibitors are some of the earliest examples of successful targeted therapies in multiple types of cancer. The tractability of EGFR as a therapeutic target is overshadowed by the inevitable drug resistance that develops. Overcoming resistance mechanisms requires a deeper understanding of EGFR regulation in cancer cells. In this review, we discuss our recent discovery that the palmitoyltransferase DHHC20 palmitoylates EGFR on the C-terminal domain and plays a critical role in signal regulation during oncogenesis. Inhibiting DHHC20 expression or mutating the palmitoylation site on EGFR alters the EGF-induced signalling kinetics from a transient signal to a sustained signal. The change in signalling is accompanied by a decrease in cell proliferation in multiple human cancer cell lines. Our in vivo studies demonstrate that ablating the gene Zdhhc20 by CRISPR/Cas9-mediated inhibition in a mouse model of oncogenic Kras-driven lung adenocarcinoma potently inhibits tumorigenesis. The negative effect on tumorigenesis is mediated by EGFR since the expression of a palmitoylation-resistant mutant form of EGFR also inhibits Kras-driven lung adenocarcinoma. Finally, reducing EGFR palmitoylation increases the sensitivity of multiple cancer cell lines to existing inhibitors of EGFR and downstream signalling effector pathways. We will discuss the implications of these effects and strategies for targeting these new vulnerabilities.
Evolution of Ray's Theory of Bureaucratic Caring

An overview and evolution of caring and the theory of bureaucratic caring and interpretations of its central categories are described. Data and models representing its theoretical development, the concept of bureaucracy, and emergence of the theory as a holographic theory are included. Central tenets in the new sciences are explored along with Bohm's corresponding ideas of explicate and implicate orders (holistic science) and spiritual-ethical caring. The theory has broad implications for increasing the knowledge of caring inter-professionally, improving the health and well-being of people, and transforming healthcare bureaucratic organizations nationally and globally, with application in the military healthcare system.
Experimental Study on Hydraulic Performance of Tiecell Caisson Breakwater with Wave Chamber

ABSTRACT Kim, I. -C. ; Park, K. , and Kang, T. -W. , 2021. Experimental study on hydraulic performance of tiecell caisson breakwater with wave chamber. In: Lee, J.L. ; Suh, K. -S. ; Lee, B. ; Shin, S. , and Lee, J. (eds.), Crisis and Integrated Management for Coastal and Marine Safety. Journal of Coastal Research, Special Issue No. 114, pp. 81–85. Coconut Creek (Florida), ISSN 0749-0208. Recently, a perforated caisson breakwater with tiecell blocks was developed to improve a water affinity and people's safety of a rubble mound armoured by tetrapods. In this study, hydraulic model tests were performed to examine the hydraulic performance of a non-porous and a tiecell caissons with perforated blocks attacking wave against a small fishery harbor near Busan. The model test results show that the tiecell caisson is more effective in dissipating wave energy under normal wave conditions and in reducing wave overtopping rates under design wave conditions than the non-porous caisson. It is found that the horizontal wave forces acting on the tiecell caisson show slightly more large than the non-porous caisson due to the impulsive force generated in the wave chamber.
icio: Economic analysis with intercountry input–output tables

Several new statistical tools and analytical frameworks have been recently developed to measure countries’ and sectors’ involvement in global value chains. Such a wealth of methodologies reflects the fact that different empirical questions call for distinct accounting methods and different levels of aggregation of trade flows. In this article, we describe icio, a new command for the computation of the most appropriate measures of trade in value added as well as participation in global value chains. icio follows the conceptual framework proposed by Borin and Mancini (2019, Policy Research Working Paper WPS 8804; WDR 2020 Background Paper, World Bank Group), which in turn extends, refines, and reconciles the other main contributions in this strand of the literature. icio is flexible enough to work with any intercountry input–output table and with any level of aggregation of trade flows.
Marketing communication tools and their influence on marketing innovation: Evidence from Slovakian SMEs

Abstract Due to lack of sources, SMEs face certain problems when applying innovative activities. Since marketing communication tools enable to perform innovative actions, SMEs’ usage of such channels might provide solutions for them to overcome the barriers of making innovation. Thus, this paper investigates whether the usage of marketing communication tools by SMEs enables them to be innovative in marketing or not, and the research question is “Does the usage of marketing communication tools by SMEs improve their innovativeness in marketing? ” This paper focuses on traditional and technology-enabled marketing communication tools, such as direct marketing, personal selling, online marketing, and advertising in social media. The researchers employ a random sampling method and then create an online internet-mediated questionnaire to collect data from 812 SMEs in Slovakia. The researchers have also performed Ordinal Logistic Regression analyses to fulfill the research aim. The results show that the usage of marketing communication tools by SMEs improves their innovative posture in marketing. The education level of firm executives and cultural factors in a specific nation might be the reasons for the findings of this research. Thus, the trainings and financial support provided by policymakers and collaboration of other institutions are beneficial for the growth of SMEs. This research analyzes traditional and technology-enabled marketing tools, and areas of marketing innovation in a broad perspective, including innovations in products/services, prices, distribution, promotion, people, processes, and visualization. Therefore, it differs from other studies and fills the research gap by making a significant value addition in related literature.
Phonological restrictions on nominal pluralization in Sign Language of the Netherlands: evidence from corpus and elicited data

Abstract This study focuses on nominal pluralization in Sign Language of the Netherlands (NGT). The aim is to offer a comprehensive description of nominal pluralization processes in the language, based on both corpus data and elicited data, taking into account potential phonological restrictions. The results reveal that NGT nouns can undergo several pluralization processes, the main ones being simple reduplication (i.e., repeating the noun sign at one location) and sideward reduplication (i.e., repeating the noun sign while moving the hand sideward). The choice of pluralization process depends on phonological properties of the base noun: (i) nouns that are body-anchored or involve a complex movement undergo simple reduplication; (ii) nouns articulated at the lateral side of the signing space undergo sideward reduplication; (iii) nouns articulated on the midsagittal plane can undergo both simple and sideward reduplication. Strikingly, the data show considerable variation, and all types of nouns can be zero-marked, that is, plural marking on the noun is not obligatory. The results further suggest that all nouns can undergo at least one type of reduplication. Thus, while phonological properties of the base noun influence the type of reduplication, they do not block reduplication altogether. Plural reduplication in NGT is therefore less constrained than has been reported for other sign languages, where certain noun types cannot undergo reduplication. This shows that reduplication – despite being iconically motivated – is subject to language-specific grammatical constraints.
Importance and Impact of the Poultry Red Mite (Dermanyssus gallinae) in Layer Farms - Analysis of Farmers’ Perception

Abstract Poultry red mite (PRM), Dermanyssus gallinae, causes egg drop production, anemia and can be a vector in transmitting diseases. The PRM control mainly focuses on usage of the conventional chemical biocides. The objective of this study was to analyze the farmers’ perception regarding the impact, management and control of PRM in Macedonian layer farms. The data were collected with direct on-site visits using a unified questionnaire. In total, 29 poultry farms (28% of farms in the country), all with conventional cages, were part of this study. The data were analyzed by descriptive statistics, inferential statistics and Naïve Bayes Classifier technique. In 30% of the poultry farms the farmers had observed that the flock was infested with PRM. In total, 32 different treatments against PRM were reported from the farmers, and three of them were non-biocide treatments. The most used biocides (17% of the farms) were crude oil, Formalin, Neopitroid® and disinfectants. The highest agreement regarding biocides application among the farms (38%) was before the production starts. Most of the farmers applied biocides routinely, before the infestation is evident (75%). The median costs for PRM treatment were 175€ per flock, higher in the infested farms 493±677€ compared to non - infested 100±71€, p<0.05. None of the Macedonian farmers included in the study was using monitoring method for PRM infestation, contributing to poor data records. This study highlights the need of developing unified strategy for PRM control included in the Integrated Pest Management in poultry layer farms.
Thyroglossal duct cyst papillary thyroid cancer – the state of the art

Abstract Thyroglossal duct cyst is one of the most common congenital malformations in the neck area. The majority of cysts turn out to be benign tumors, however, 0.7-1.5 % of the remnants develop into carcinoma, with papillary thyroid cancer being the most frequent malignant neoplasm. The origin of the cancer has not been clearly established so far. Typically, thyroglossal duct cyst cancer is an enlarging flexible midline or slightly lateral neck mass, most often without other worrisome symptoms. The proper diagnosis can be difficult due to the rare prevalence of thyroglossal duct cyst papillary thyroid carcinoma, as well as a lack of strongly typical features distinguishing benign and malignant lesions before surgery. Thus, diagnosis is usually made postoperatively just after histopathological examination of a resected cyst. However, there are diagnostic procedures that should be considered before the surgery that may be helpful in making a proper diagnosis. These include fine-needle aspiration biopsy, computed tomography or magnetic resonance imaging. Moreover, there are some characteristics revealed through clinical and ultrasound examination that may suggest the presence of such cancer. While the Sistrunk procedure is often considered adequate, currently, there is no clear consensus about concurrent thyroidectomy or radioiodine therapy. In the article, we sum up the preoperative suggestive factors of cancer, as well as the proposed indications that can be helpful in deciding on the extent of surgery and further management.
Connecting the Dots: Exploring the Knowledge-based Antecedents of SMEs’ Profitability and Development via International Ventures

Abstract As shifts occur on the global market and business models adapt to a dynamic environment, the process of business internationalization, as performed by small and medium-sized enterprises (SMEs), maintains its relevance for academics, professionals, international organizations, and authorities. Studies in the field have emphasized the strategic component of internationalization, linking it to cultivating (sustainable) competitive advantages, to stimulating strategic innovation, to the pursuit of profitability, and to an overall improved performance, taking into account the activities conducted on foreign markets. Based on a survey carried out with over 100 European SMEs in the steel field, this study examines the influences of strategic collaborators (from international business networks), intermediaries (as organizational links to the target stakeholders), and strategic innovation on SMEs’ profitability resulted from international operations, and on the level of business development on foreign markets. The results have shown positive influences among most of the considered factors (i.e., direct collaborators, strategic innovation, international profitability and development), whereas intermediaries have a significant influence only on international profitability and not on SMEs’ development on foreign markets.
A validation and reliability study of the Movement Environmental Rating Scale (MOVERS)

ABSTRACT The aim of this study was to determine the validity and reliability of the Movement Environment Rating Scale (MOVERS), using data from 13 early childhood education and care (ECEC) settings. Test-retest reliability was calculated using ICCs, percentage agreement and weighted Kappa. Internal consistency was examined using Cronbach’s alpha. To examine concurrent validity between the MOVERS and Sustained Shared Thinking and Emotional Well-being Scale (SSTEW) scale and the Environmental Policy and Assessment Observation (EPAO), correlation coefficients were computed. Multi-level regression analyses were conducted to examine the criterion validity of MOVERS and children’s outcomes. ICC was 0.959 (p < 0.0001), weighted Kappa was 0.904 (p < 0.001), and percentage agreement was 69%–100%. Cronbach’s alpha of MOVERS was α = 0.94 and α = 0.89. Statistically significant correlations between MOVERS subscales and some SSTEW and EPAO sub-areas were reported. Item 4 (Body movement to support fine motor skills) of MOVERS and children’s fine motor skills was significantly correlated. This study shows that MOVERS is a reliable and valid scale that can, with training, be confidently used for research, audit, self-evaluation for practice improvement.
Rethinking the DMZ as the commons: the affective possibilities of the DMZ

ABSTRACT This study provides a critical analysis of the representation of the DMZ in South Korea as an eco-peace area in the post-Cold War era, shedding light on how to deconstruct the Eco-Peace-Oriented Discourses (EODs) and to unveiling the marginalized nature of the DMZ and border society. Challenging how the current academic discourses distort the nature of the DMZ as a mythological space, this article aims to provide an alternative perspective to the DMZ border society by focusing on the affective relationality of landmines with environment and humans in the border area. In particular, it argues that we should rethink the DMZ as the marginalized border society by paying attention to the following three aspects: (1) the main features of EODs; (2) the gap between the mythology of the EODs and the marginalized reality of the DMZ border society; and (3) the slow violence of landmines and the internalized, invisible, and affective marginalization of the border society.
Linguistic Cues to Misrepresentation in Online Employer Reviews

Employees may engage in some misrepresentation on employer review websites (e.g., GlassDoor, Indeed), even when reviewing an employer anonymously. This research explores how linguistic features of employee-generated reviews (N = 204) might serve as a means of detecting misrepresentation, presentations of the organization that depart from one’s personal beliefs, in employer reviews. Findings suggest language analytics may not be a fruitful means of detecting deception in online employer reviews. Results are discussed with respect to employees’ self-presentation of their employers and the linguistics of misrepresentation.
Perceptions of science teachers’ growth-mindset practices and U.S. high school students’ initial science identity and its development

ABSTRACT High school is a critical period for science identity development. Teacher influences are important but under-researched. Teachers’ growth-mindset practices may help students meet the growing challenges to their ability, achievement, and identity in science and have long-term influences, especially for underrepresented students. We explored U.S. high school students’ perceptions of science teachers’ growth-mindset practices at ninth grade and the effect on the mean development trajectory of their science identity over six years. Three waves of data from a nationally representative sample of 15,648 students were analysed through longitudinal multilevel models. Data from underrepresented ethnic minorities (n = 4,485), students with low socioeconomic status (low-SES) (n = 2,219), and female students (n = 7,823) were analysed separately from the overall sample. Perceived teachers’ growth-mindset practices significantly predicted initial science identity at ninth grade for the overall sample, ethnic minorities, and female students, as well as science identity development over time for all four samples, before controlling student competence beliefs, gender, race, and SES. The long-term effect was more salient for the ethnic minority and low-SES students. We extended prior work by examining the effect of perceived teachers’ mindset practices in the science discipline, particularly the long-term effect, while most research on STEM motivation and identity from a growth mindset perspective focused on student mindset, the math discipline, and the short-term effect of mindset. Results suggest continued teacher training on growth mindset for helping students develop science identity, especially for ethnic minority and low-SES students.