Miracle-dz/UniFAR-FTUs huggingface dataset:
ANTIOXIDANT AND ANTITUMOR ACTIVITY OF EUPHORBIA MILII FLOWER EXTRACT AGAINST IN VIVO BREAST CANCER AND COLON CANCER IN MICE.

Purpose: Euphorbia milii, a flowering plant belonging to spurge family Euphorbiaceae is widely used in the folk medicine for the treatment of warts, hepatitis and cancer. The aim of present study is to evaluate the antioxidant and antitumor properties of ethyl acetate extract of Euphorbia milii flower (EAEEMF) against MCF-7 cell line induced breast cancer and CACO-2 cell line induced colon cancer in mice. Methods: The MCF-7 cell lines were induced subcutaneously in mammary region in female mice and CACO-2 cell lines were induced intraperitoneally. The animals were treated with ethyl acetate extract of Euphorbia milii flower at doses of 200mg/kg and 400mg/kg p.o. , consecutively for 30 days. On 31 st day the animal‟s body weight and body circumference was noted and mice were sacrificed. The antioxidant and anticancer activity of ethyl acetate extract of Euphorbia milii flower was assessed by evaluating haematological, antioxidant and serum biochemical parameters. Results: Ethyl acetate extract of Euphorbia milii flower decreased body weight and body circumference. Haematological profile such as RBC, haemoglobin, haematocrit and WBC count reverted to normal level in ethyl acetate extract of Euphorbia milii flower treated groups of mice. The extract significantly decreased the levels of lipid peroxidation and elevated the levels of GSH, GPx and catalase. Serum biochemical parameters such as lactate dehydrogenase (LDH), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT), alanine transaminase (ALT), and Glucose were reverted to normal levels in ethyl acetate extract of Euphorbia milii flower treated groups. The cancer specific parameters like Ferritin and Carcino embryonic antigen (CEA) also significantly decreased in extract treated groups. Histopathology report WO
Economical and Green Acetaldehyde to Glyoxal Electroorganic Conversion: a Theoretical Study

An interesting electro organic economic and green method of acetaldehyde to glyoxal conversion, based on electrochemical oxidation over a selenite-doped conducting polymer, has been described theoretically. A mathematical model, correspondent to the process, has been developed and analyzed by means of the linear stability theory and bifurcation analysis. The model analysis has confirmed the efficiency of the model for glyoxal laboratory and industrial production by the electrocatalytic method. Although the oscillatory behavior is possible in this system, it won ́t influence the glyoxal yield strongly.
The Toxicity of Five Native Thai Plants to Aquatic Organisms

Five species or native Thai plants were bioassayed as toxicants against the cladoceran Moina sp. , the fishes Oreochromis niloticus and Anabas testudineus, the shrimp Penaeus merguiensis, and the snail Cerithidea cingulata. The 24-h LC50 of each plant to each test species was determined. Diospyros diepenhorstii is the least effective plant extract against all five test organisms, while Maesa ramentacea and Sapindus emarginatus are the most effective plant extracts against Moina sp. , 0. niloticus and A. testudineus. The lethal concentrations of all plant extracts to test fish are greater than that to shrimp. Moreover, all plant extracts are more effective against 0. niloticus than A. testudineus. Pittosporum ferrugineum and S. emarginatus have potential against snail pests. Among the five plants, M. ramentacea showed the highest toxicity to 0. niloticus. Toxicity to 0. niloticus or M. ramentacea (15-30 mg,J-1) was about half that of tea seed cake (6-15 mg,J·1). However, improvement of M. ramentacea toxicity is feasible. These results are useful for developing botanical pesticides for selective killing of undesired aquatic organisms.
Las manchas en los huevos de estornino Sturnus unicolor son un buen indicador de la carga ectoparásita de la mosca Carnus hemapterus (Diptera: Carnidae)

Se ha sugerido que los puntos marrones que aparecen en los huevos de estornino negro una vez comenzada la incubacion podrian relacionarse con la abundancia de ectoparasitos del nido. Para poner a prueba esta hipotesis se manipulo la carga ectoparasita de los nidos rociandolos con insecticida (grupo experimental) o con agua (grupo control) y se comparo el numero de puntos entre ambos grupos. Se encontro una relacion positiva entre el numero de moscas (Carnus hemapterus) en el nido y el numero medio de puntos en los huevos. Los nidos experimentales presentaron un menor numero de puntos que los controles. Nuestro estudio demuestra que los puntos de los huevos de estornino negro son producidos por la presencia la mosca parasita C. hemapterus.
Short-Term Physiological Disruption and Reflex Impairment in Shortnose Sturgeon Exposed to Catch-and-Release Angling

Sturgeons (Acipenseridae) are the most imperilled group of fishes globally. Yet, many species remain important targets of recreational anglers. In the Saint John River, New Brunswick, Shortnose Sturgeon Acipenser brevirostrum is a popular species targeted by recreational anglers. The International Union for the Conservation of Nature has placed Shortnose Sturgeon on the Red List as “Vulnerable,” and therefore this species is afforded protection from harvest in Canada by the federal Species at Risk Act. Here, we evaluated physiological stress using two principal components axes, RC1 and RC2, generated from blood lactate, glucose, and pH, hematocrit, and reflex impairment of sturgeon exposed to exhaustive chase experiments at a hatchery and angled sturgeon that were captured during an annual fall competitive angling event. Physiological indicators of stress increased with holding time for Shortnose Sturgeon transferred into a tank and for sturgeon exposed to chase trials. Circulating metabolite concentrations were not associated with reflex impairment. The odds of reflex impairment increased as a function of air exposure, with a 1-min increase in air exposure increasing the odds of impairment by 1.78. All sturgeon survived hatchery experiments. Most of the wild Shortnose Sturgeon captured in the fishing derby (71%) exhibited reflex impairment, and 38% had superficial injuries such as cuts or wounds. None of these factors were associated with physiological disturbance, although ordinated stress physiology axes were elevated both 1 and 2 h after initial sampling, which was predictive by the holding time prior to weigh-in and measuring fish size. All fish were hooked in the mouth and each was released alive from the derby. Taken together the evidence suggests that Shortnose Sturgeon are resilient to recreational angling interactions, yet managers could use this information to improve best practices of catch-and-release angling.
Phenotypes and natural history of food protein-induced enterocolitis syndrome in the east Mediterranean region.

Background: Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE mediated food allergy. Objective: To delineate the differences in the spectrum of culprit foods, remission patterns, and predictors among varying cultures. Methods: We reviewed demographics, culprit foods, outcomes, and predictors in 81 children with a diagnosis of FPIES who were followed up between 2015 and 2020. Results: Eighty-one patients (55.6% boys) were enrolled, including 72 with acute FPIES and 9 with chronic FPIES. Hen's egg was the most common culprit food (36.6%), followed by fish (26.9%), and cow's milk (21.5%). Interestingly, cow's milk was significantly prevalent in chronic FPIES cases (p = 0.006). The most common clinical symptoms were vomiting (100%), pallor (63.4%), and lethargy (55.9%). Emergency department visits were noted in 39 patients (41.9%), of whom 37 (39.8%) were treated with intravenous (IV) fluid. The subjects were followed up for a median (interquartile range) of 19.4 months (12.3-41.2 months), and 26 subjects (32.1%) achieved tolerance. The median (interquartile range) age at tolerance was 2.5 years (2.1-3.2 years). With regard to the culprit foods, hen's egg was observed more frequently in the subjects with resolved FPIES cases (p = 0.008), whereas fish FPIES cases were high in the persistent group (p = 0.001). IgE sensitization of the culprit food was found to be an independent risk factor for the persistence of FPIES (odds ratio 4.855 [95% confidence interval, 1.131-20.844]; p = 0.034). Conclusion: In our cohort, unlike other published series, hen's egg and fish were the two most common culprit foods. Fish differed from other culprit foods, with significantly delayed onset and persistence, and may create a model that allows for the understanding of the disease.
Income ranking, convergence speeds, and growth effects of inequality with two-dimensional adjustment

We present a growth model that converges to its balanced path by adjusting both inequality and the ratio of physical to human capital. This two-dimensional adjustment sheds light on some puzzling issues in models with one-dimensional adjustment. It shows in transition initial inequality hinders output growth but affects human capital growth ambiguously. It can produce the empirically estimated 2% rate of convergence for standard values of share parameters. It allows the convergence speed to vary according to initial states and education regimes, and explains why the OECD countries converge faster than others. It also permits rapid overtaking in income ranking among countries that share the same balanced path.
The Journey Bicruciate Knee Replacement: Design modifications Yield Better Early Functional Results and Reduce Complications

Abstract The Journey-I total knee replacement was designed to improve knee kinematics but had several complications including early dislocation. The Journey-II modification was introduced to reduce these while maintaining high function. To assess whether the modified Journey-II prosthesis has succeeded in its designers aims, we undertook an observational study of prospectively recorded data to analyze and compare the two knees. A total of 217 Journey-I and 129 Journey-II knees were identified from the department's prospectively collated registry and were assessed at 1 year by a comparative statistical analysis using numerous factors including pain, functional activity, physical assessment, Short Form-12 (SF-12), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and Oxford scores. The statistical tests included Chi-square, Wilcoxon's rank and Mann–Whitney U-tests with the level of significance set at p < 0.05. There was a variation in primary patella resurfacing between the two groups with 14.3% in the Journey-I cohort and 66.7% in the Journey-II cohort. Both replacements demonstrated excellent postoperative function, but the Journey II performed significantly better than Journey I with fewer complications (37 vs. 10) and better improvement in almost all clinical scores including pain (p < 0.01), mobility outcomes (p = 0.018), Oxford (p = 0.004), and WOMAC (p = 0.039) scores but not with flexion improvement and SF-12 score. There was significant improvement in patellofemoral pain postoperatively in both the Journey I (p = 0.011) and Journey II (p = 0.042) arthroplasty; however the primarily resurfaced patella in a Journey-II implant had better postoperative scores. The main complication of dislocation in the Journey I was not seen in the modified Journey-II implant with stiffness requiring intervention reduced in Journey II. These results suggest that the Journey II has improved short-term clinical outcomes compared with Journey I with reduction of dislocation and other complications.
Two Measures of Interoceptive Sensibility and the Relationship With Introversion and Neuroticism in an Adult Population

Interoception, the ability to detect internal bodily signals, is vital for an individual’s well-being and is increasingly connected to mental health disorders. Research investigating relationships between individual differences in interoception and personality types is limited, and mixed results are reported across a variety of interoceptive tasks, measures, and conceptualisations. Guided by biological theories, this study contributed further to the understanding of the relationship between interoception and personality by utilising two interoceptive measures. A sample of adults (N = 114) completed three questionnaires online questionnaire, two assessing interoceptive sensibility (Body Perception Questionnaire, BPQ; and the Multidimensional Assessment of Interoceptive Awareness, MAIA) and one that assessed personality (Eysenck Personality Inventory, EPI). Multiple regression and correlational analyses showed no significant relationship between interoceptive sensibility and introversion, whereas a predictive relationship was demonstrated between interoceptive sensibility and neuroticism. Furthermore, the BPQ and subscales of the MAIA predicted neuroticism in different directions suggesting the two measures assess different constructs and thus strengthened support for a multidimensional consideration of interoception. The results have clinical implications, including the targeting of contemplative training approaches for individuals demonstrating high interoceptive sensibility and neurotic traits to improve the mental well-being of healthy individuals and clinical populations.
Simulating permeability reduction by clay mineral nanopores in a tight sandstone by combining μXCT and FIB-SEM imaging

Abstract. Computer microtomography (µXCT) represents a powerful tool for investigating the physical properties of porous rocks. While calculated porosities determined by this method typically match experimental measurements, computed permeabilities are often overestimated by more than one order of magnitude. This effect increases towards smaller pore sizes, as shown in this study, in which nanostructural features related to clay minerals reduce the permeability of tight reservoir sandstone samples. FIB-SEM tomography was applied to determine the permeability effects of illites at the nanometre scale and Navier-Stokes-equations were applied to calculate the permeability of these domains. With this data, microporous domains (porous voxels) were defined using microtomography images of a tight reservoir sample. The distribution of these domains could be extrapolated by calibration against size distributions measured in FIB-SEM images. For this, we assumed a mean permeability for the dominant clay mineral (illite) in the rock and assigned it to the microporous domains within the structure. The results prove the applicability of our novel approach by combining FIB-SEM with X-ray tomographic rock core scans to achieve a good correspondence between measured and simulated permeabilities. This methodology results in a more accurate representation of reservoir rock permeability in comparison to that estimated purely based on µXCT images.
Resilience effects on student performance and well-being: the role of self-efficacy, self-set goals, and anxiety

Abstract Universities prepare students to become contributing members to the workplace and to society. However, with rising tuition costs and other increasing time and resource demands, students face substantial adversity. Students’ ability to cope with that adversity influences successful completion of academic coursework and retention in degree programs, ultimately providing a source of potential effective future employees. Previous research has demonstrated numerous direct relationships between dispositional resilience and pivotal outcomes, such as performance, life satisfaction, and subjective well-being. However, research has failed to explore underlying mechanisms through which resilience may affect these outcomes, especially in academic contexts. The purpose of the current study was to use self-regulation theory as a framework for examining the effects of students’ resilience on outcomes. Using a sample of undergraduate students from a Midwestern university in the U.S. (N = 141), we proposed and tested a path model addressing self-efficacy, self-set goals, and state anxiety as mechanisms through which resilience influences performance and subjective well-being. Our results provided evidence supporting a structural model involving resilience, such that student resilience (a) has an indirect effect on performance through self-efficacy and self-set goals, (b) has an indirect effect on state anxiety through self-efficacy, and (c) accounts for unique variance in subjective well-being after controlling for state anxiety. Implications, limitations, and directions for future research are discussed.
Vitamin D as a possible biomarker of mild cognitive impairment in parkinsonians

Abstract Introduction Mild Cognitive Impairment in Parkinson’s Disease (PD-MCI) is a transitional state between normal cognition and dementia. Cross-sectional studies revealed that low Vitamin D levels were associated with worse performance on cognitive tests in Parkinson’s Disease. The present longitudinal study aimed to examine the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels at baseline and possible development of PD-MCI at 24 and 48 months. Materials and Methods Sixty untreated, de novo PD patients underwent clinical and cognitive evaluations and measurement of serum 25(OH)D at baseline assessment (T0). After 24 (T1) and 48 months (T2), cognitive status (presence or absence of PD-MCI) of PD patients were re-evaluated. Results Vitamin D insufficiency occurred in 93.3% at T0. At T1, significant differences among patients with PD-MCI at both baseline and follow-up, patients with PD-MCI at follow-up and patients who never developed PD-MCI were found on age, age at onset of PD, and education; no significant difference was found on vitamin D levels at T0. A binary logistic regression analysis showed that a lower level of 25(OH)D at T0 (B= −0.158, Wald= 5.280, p = 0.022, Exp (B)=0.854; CI 95%: 0.746-0.977) and lower education (B= −0.214, Wald= 3.859, p = 0.049, Exp (B)=0.807; CI 95%: 0652-1.000) were predictors of PD-MCI occurrence at T2. Discussion Our results demonstrated that a lower level of 25(OH)D is conceivable as a biomarker of development of PD-MCI throughout the disease. Early diagnosis of Vitamin D insufficiency and its management might be useful to prevent cognitive decline in PD patients.
Arterial Stiffness and Cardiorespiratory Fitness Are Associated With Cognitive Function in Older Adults

Abstract Age-related cognitive impairment has been associated with arterial stiffening and decreased cardiorespiratory fitness. The aims of this cross-sectional study were to compare cognitive function domains and cardiovascular parameters in older adults (≥ 65 years old) with high and normal aortic stiffness (via carotid-femoral pulse wave velocity, cfPWV) and to explore relationships among cfPWV, carotid intima-media thickness, cardiorespiratory fitness, and cognitive function. Vascular and cognitive function were measured in older adults with either normal or high cfPWV. Cognitive function was measured via an intensive one-time neuropsychological battery, while cfPWV by applanation tonometry, carotid intima-media thickness and function (i.e., distensibility) by ultrasonography, and cardiorespiratory fitness (i.e., VO2peak) by a submaximal exercise test. Correlations among age, VO2peak, carotid intima-media thickness, cfPWV, and cognitive function were performed along with a series of multivariate analyses of variance. Compared with NAS, participants with HAS had greater aortic, carotid, and brachial blood pressures but similar cardiorespiratory fitness and carotid intima-media thickness and distensibility. Participants with NAS exhibited better neuropsychological performance in executive function and attention and overall cognitive function than those with HAS. When controlling for age, visual scanning and perception scores were correlated with cfPWV and VO2peak. Our findings suggest that certain cognitive domains for older adults are associated with their cardiorespiratory fitness and aortic stiffness.
End-of-Life Experiences (ELEs) of Spiritual Nature Are Reported Directly by Patients Receiving Palliative Care in a Highly Secular Country: A Qualitative Study

Introduction: Patients with life-threatening diseases have reportedly end-of-life experiences that are perceived positively. Loved ones and healthcare personnel may mistakenly interpret the phenomena as confusion and patients can be reluctant to talk about it due to fear of ridicule. Studies addressing patients directly are scarce and there is a lack of studies from highly secular countries. The aim was to establish whether end-of-life experiences are present among patients, oriented in time, place and person and receiving palliative end-of-life care in one of the world's most secular countries. If present, examine the content and patients’ subjective experiences. Design: Qualitative design with semi-structured, in-depth interviews. 25 participants, receiving end-of-life palliative care at home or in a hospice inpatient unit. Results: Patients were interviewed on 1-3 consecutive occasions. 16/25 patients reported end-of-life experiences of which the majority were perceived to be positive. Four themes were identified: vivid dreams while asleep, experiences while awake, references to medical circumstances and communication about end-of-life experiences. Prevalent content was deceased and living loved ones and journeys. Some patients distinguished between hallucinations/nightmares and end-of-life experiences. Conclusions: End-of-life experiences are present among oriented patients in a highly secular country and can have a profound positive impact, which warrants clinical attention. Education for healthcare personnel about end-of-life experiences is needed in order to support patients and loved ones and not mistakenly medicalize. Further directions for research could be to study the experiences of the phenomenon among health care personnel in the same context, which could strengthen the present findings.
Dietary supplements in the management of varicocele‐induced infertility: A review of potential mechanisms

Varicocele is a main cause of lower production of spermatozoon and infertility with multiple pathophysiological mechanisms. In the past decades, the use of dietary supplements has significantly increased due to both the modern lifestyle and the food shortages of the industrialised countries. The purpose of this review paper is to collect scientific evidences from basic and clinical studies which support the use of dietary supplements to define the clinical framework for patients with varicocele. In the present review, we used keywords such as dietary supplements, varicocele, male infertility, oxidative stress, DNA fragmentation, sperm parameters to find the proper articles. The standard search biomedical engines were used for seeking the papers. The use of dietary supplements such as minerals, vitamins and antioxidants has an essential role in the prevention and treatment of varicocele by increasing the levels of antioxidant enzymes (e.g. peroxidase, superoxide dismutase and catalase) and decreasing the levels of inflammatory markers (e.g. tumour necrosis factor‐α, interleukin‐6 and interleukin‐1) in testis. According to the results, the dietary supplements may alleviate the spermatogenesis in varicocele patients through different mechanisms such as suppression of stress oxidative and inflammation in testicular tissue.