Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiovascular and Gas Exchange Effects of Individualized Positive End-Expiratory Pressures in Cats Anesthetized With Isoflurane

Objectives To compare the effects of four levels of end-expiratory pressure [zero (ZEEP) and three levels of positive end-expiratory pressure (PEEP)] on the cardiovascular system and gas exchange of cats anesthetized with isoflurane and mechanically ventilated for 3 h with a tidal volume of 10 ml/kg. Study Design Prospective, randomized, controlled trial. Animals Six healthy male neutered purpose-bred cats. Methods Anesthesia was induced with isoflurane and maintained at 1.3 minimum alveolar concentration. PEEP of maximal respiratory compliance (PEEPmaxCrs) was identified in a decremental PEEP titration, and cats were randomly ventilated for 3 h with one of the following end-expiratory pressures: ZEEP, PEEPmaxCrs minus 2 cmH2O (PEEPmaxCrs−2), PEEPmaxCrs, and PEEPmaxCrs plus 2 cmH2O (PEEPmaxCrs+2). Cardiovascular and gas exchange variables were recorded at 5, 30, 60, 120, and 180 min (T5 to T180, respectively) of ventilation and compared between and within ventilation treatments with mixed-model ANOVA followed by Dunnet's and Tukey's tests (normal distribution) or Friedman test followed by the Dunn's test (non-normal distribution). Significance to reject the null hypothesis was considered p < 0.05. Results Mean arterial pressure (MAP—mmHg) was lower in PEEPmaxCrs+2 [63 (49–69); median (range)] when compared to ZEEP [71 (67–113)] at T5 and stroke index (ml/beat/kg) was lower in PEEPmaxCrs+2 (0.70 ± 0.20; mean ± SD) than in ZEEP (0.90 ± 0.20) at T60. Cardiac index, oxygen delivery index (DO2I), systemic vascular resistance index, and shunt fraction were not significantly different between treatments. The ratio between arterial partial pressure and inspired concentration of oxygen (PaO2/FIO2) was lower in ZEEP than in the PEEP treatments at various time points. At T180, DO2I was higher when compared to T5 in PEEPmaxCrs. Dopamine was required to maintain MAP higher than 60 mmHg in one cat during PEEPmaxCrs and in three cats during PEEPmaxCrs+2. Conclusion In cats anesthetized with isoflurane and mechanically ventilated for 3 h, all levels of PEEP mildly improved gas exchange with no significant difference in DO2I when compared to ZEEP. The PEEP levels higher than PEEPmaxCrs−2 caused more cardiovascular depression, and dopamine was an effective treatment. A temporal increase in DO2I was observed in the cats ventilated with PEEPmaxCrs. The effects of these levels of PEEP on respiratory mechanics, ventilation-induced lung injury, as well as in obese and critically ill cats deserve future investigation for a better understanding of the clinical use of PEEP in this species.
Collaboration through innovation: implications for expertise in the AEC sector

Collaboration is key for successful delivery of building projects in the Architecture, Engineering and Construction (AEC) sector. Innovative project delivery approaches developed over the past two decades envision new ways of collaborating and specifically aim at improving the performance of and value generated by this key economic sector. Collaboration, however, remains an ill-defined and highly amorphous concept. This makes it difficult to investigate and consequently develop a body of knowledge, which is central to defining a field of expertise in this area. The aim of this investigation is to explore the notion of an expertise in collaboration in the AEC sector and the implications of these innovative project delivery approaches on this expertise. The concept of collaboration is developed across five core entities: structure, process, agents, artefacts and context. These entities are then framed through a critical realist lens to lay the groundwork for a body of knowledge of collaboration in the AEC sector. The impact of the current shift to these innovative approaches is investigated within this framing. The findings set a course of action to develop a body of knowledge and a field of expertise on collaboration in the AEC sector.
Agronomic zinc biofortification and its impact on mineral composition of eight okra genotypes [Abelmoschus esculentus (L.) Moench] in an acid Alfisol

Abstract Food security, agricultural sustainability, and nutritional security are global challenges for the present and future generations. Agronomic zinc (Zn) biofortification of crops is one of the best approaches to achieve the desired goal, with Zn being the most deficient soil micronutrient globally. With an aim to study the impact of Zn fertilization on okra pod mineral composition and to screen out the Zn efficient and responsive okra genotypes among the tested ones, a field experiment was conducted with eight genotypes and three Zn levels [0, 25 kg zinc sulfate heptahydrate (ZnSO4.7H2O) ha−1 as basal, and 25 kg ZnSO4.7H2O ha−1 as basal + two foliar sprays of ZnSO4.7H2O @ 0.5%) in a split-plot design with three replications. A significantly higher pod and straw yields were recorded for the Ankita genotype. While highest total Zn uptake was registered for the genotypes Hissar Unnat, Ankita, and Pusa Makhmali. The results also showed that the significantly highest Zn content in okra pod was recorded in NOKH-1012 genotype compared to the rest of genotypes at different levels of Zn application. The yield efficiency index varied from 81.1 (Hissar Unnat) to 89.2 (Pusa Makhmali), whereas, the uptake efficiency index varied from 52.7 (Hissar Unnat) to 75.6 (NOKH-1012). Based on yield and uptake efficiency indices, the okra genotypes were classified as efficient and responsive [Perkins Long Green (PLG), NOKH-1012, and Kiran Hybrid], inefficient and responsive [Punjab-8 (P-8), Ankita], efficient and non-responsive, (Pusa Makhmali), and inefficient and non-responsive (Hissar Unnat and Palam Komal).
Ultrasound-Guided Tru-Cut Biopsy in Gynecological and Non-Gynecological Pelvic Masses: A Single-Center Experience

Aim: The aim of this study was to evaluate the feasibility of adequacy, accuracy, and safety of ultrasound-guided tru-cut biopsy in managing malignant and benign abdominopelvic masses in a selected population and critically discuss some issues in different situations, which deserve some reflections on those practices. Materials and Methods: This is a retrospective study involving 42 patients who underwent transvaginal or transabdominal tru-cut biopsy between August 2017 and November 2021. The inclusion criteria were poor health status or primary inoperable advanced tumor, suspicion of recurrence or metastasis to the ovaries or peritoneum in gynecological and non-gynecological pelvic malignancies. Tissue samples were considered adequate if it was possible to determine the origin of the tumor, and immunohistochemistry could be performed. Diagnostic accuracy was assessed considering the agreement between tru-cut biopsy histology and final postoperative histology. Results: It total, 44 biopsies were obtained from 42 patients (2 patients had repeat biopsies). The pathologist considered all pathological samples adequate (adequacy 100%). The final histology was consistent with tru-cut biopsy diagnosis in all but 2 cases (diagnostic accuracy 88.2%). If we consider only the cases that have carried out at least two diagnostic samples, accuracy rose to 94.1%. Pathological examinations from tru-cut samples showed 2 benign lesions (4.8%) and 40 malignant tumors (95.2%), divided into 19 advanced primary inoperable ovarian cancers, 7 primary advanced cervical cancers, 4 recurrent endometrial cancers, 3 recurrent cervical cancers, 3 recurrent ovarian cancers, 1 case of primitive peritoneal malignancy (leiomyosarcoma), and 3 non-gynecological cancers with a strong suspicion of metastases at ultrasound (2 cases of ovarian, colorectal cancer metastasis, and 1 case of pelvic site type B lymphoma metastasis). However, one case of minor complication related to the procedure was reported but not significant. Conclusions: The diagnostic adequacy, accuracy of the tru-cut biopsy, and safety were high. Pathological samples are representative of the disease and suitable for histological and immunohistochemical analysis.
Along‐strike variation in the shear wave crustal structure of the NE Himalayan and Indo‐Burmese arc: Evidence based on surface wave dispersion analysis

Surface wave dispersion data is used to infer the shear wave velocity structure variation in the north‐east Himalaya and Indo‐Burmese arc regions. We have used 25 earthquakes data from four groups with a magnitude range of 5.0–6.7, epicentral distance range 368–800 km, and focal depth less than 50 km. Ray paths from the earthquake location to the seismic station are transversely passing different geotectonic units of the Himalayas, Indo‐Gangetic plains, and Indo‐Burma collision zones. The weighted average dispersion curve and the path averaged shear wave velocity models are computed for the four groups located at different azimuths around Shillong seismic station. Non‐linear least‐square inversion is performed to obtain the shear wave velocity structure of the crust and uppermost mantle from joint inversion of Rayleigh and Love waves group velocities. Subsequently, Rayleigh and Love waves group velocities are inverted separately to obtain vertical and horizontal components of S‐wave velocity. Next, using these components anisotropy coefficient values at different depths for each path are also estimated. A high variation of dispersion curves and the shear wave velocity models from one group to another indicates that the region is geotectonically very complex. An approximately 80 km‐thick zone beneath the study region has shear wave velocity as low as 1.7 km/s in the uppermost crust in the southern part and ~4.7 km in the uppermost mantle beneath the Eastern Himalayan Syntaxis (EHS). Inferred velocity is also lower than that of PREM and AK135 global models with a much thicker crust beneath the study region. Radial anisotropy varies even within the northern part from the Indo‐Eurasian collision zone to EHS and northern to southern Indo‐Burma ranges. Anisotropy is comparatively stronger in the deeper part below ~40 km for the three paths, except for the EHS, where the result is contrary.
Different approaches - common conclusions: the skills debate of the 21st century

This paper presents the findings and analysis of research undertaken in both the United Kingdom and Australia to identify the range of knowledge and skills required by library and information professional to meet the challenges of the 21 century. In the United Kingdom, the Chartered Institute for Library and Information Professionals has developed a new qualifications framework and revised the body of professional knowledge for information professionals. In Australia, the research has focused on the two complementary and intertwined strands of discipline knowledge and generic capabilities. The issues that arise from the two projects are relevant to all sectors of the library and information profession, to stimulate discussion about possible strategies for workforce planning. Career-long learning has become an imperative for information professionals, with the research findings highlighting the importance of a collaborative approach to professional development to involve the individual, educators, employers and professional associations.
Characteristics of Buffalo Production and Research Systems in Southern Mexico

Background: This research aimed to characterize the production units of water buffalo (Bubalus bubalis) and review the published scientific literature in southeastern Mexico. Methods: Between May and June 2020, a questionnaire was created in Google forms, distributed through social networks, and emailed to buffalo breeders. In addition, a review of different scientific databases on the experimental studies developed in Mexico on buffalo was performed. Results: Data was collected from 8,867 animals from 13 producers located in southeastern Mexico; dual-purpose (milk-meat) is the primary zootechnical purpose (69.24%), and the rest is meat production. The buffalo herd is mainly composed of females (72.09%). Females are used primarily to repopulate the herd and males for meat production. Mortality in adults remained between 2 to 5%. 30.76% of the producers produce milk (495 females) with 5.1 L/d on average. 100% of the producers stated that they transform the milk into dairy products, mainly cheeses and other products. In the case of meat production, 31.97% of the males are fattened based on pastures with a weight range between 400-600 kg at the age of 22 months (range 18-30 months). Between 2012-and 2021, 19 studies related mainly to herd health (63.15%) were registered. Conclusion: It is concluded that this Mexican species has great productive potential with different areas for improvement. Due to sanitary management and rusticity, mortality is low. It is necessary to develop other lines of research associated with the reproduction, production of milk/meat, health, quality of products, safety, and sustainability of buffalo activity in Mexico.
How Do Adolescents Use Social Networks and What Are Their Potential Dangers? A Qualitative Study of Gender Differences

The rapid development of software applications and the increasing use of the Internet have raised many questions about the impact of this technology on the lives of adolescents, especially on “digital natives. ” The advent of social networks (SNs) restructures their relationships in various ways, affecting both adolescents’ development and mental health. The present study aims to investigate uses and dangers of SNs according to a sample of 296 (166 female and 130 male) Italian middle and high schools adolescents (age range 13–18) and build a model of how SNs can turn out to be dangerous. To achieve this, twenty-four audio-recorded focus groups of Italian male and female adolescents were investigated by a Grounded Theory approach, abstracting from the transcripts the main uses and dangers of SNs and proposing a final model for the interpretation of the whole set of categories. The results highlighted two main dangers of SNs: (a) the desperate search for popularity, and (b) the exhibition of violent or offensive behavior facilitated by the sense of protection and anonymity derived from being hidden behind a virtual account. Finally, a psychological model of how SNs can turn out to be dangerous is presented. This study could be useful in developing prevention procedures against the risks of SNs (e.g., cyberbullying, internet addiction) without demonizing the use of social media as such.
Do Thymus vulgaris and Rosmarinus officinalis dietary supplementations induce cytogenetic alterations in the juvenile Nile tilapia Oreochromis niloticus?

Medicinal plants provide a cheaper and sustainable alternative to chemotherapy in aquaculture; however, its misuse could be potentially toxic to both aquatic animals and humans. This study aimed to evaluate the potential cytogenetic and biochemical effects of thyme and rosemary powder supplemented diets on the Nile tilapia juvenile. Fish (26±1.5 g) were distributed into 5 groups and fed a non-supplemented diet (control), supplemented diets with thyme at a concentration of 1% and 1.5%, and diets supplemented with rosemary at a concentration of 0.5% and 1% for 6 weeks. Cytogenetical assessment (chromosome aberrations, micronucleated erythrocytes, and DNA fragmentation) was performed after 2, 4, and 6 weeks of feeding. In addition, hepatic enzymes (aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase), renal indicators (urea and creatinine), and muscle damage biomarkers (creatine phosphokinase, [CPK] and lactate dehydrogenase, [LDH]) were analyzed after 2 and 6 weeks feeding. The clinically examined fish in the group fed with 1% rosemary showed restlessness and lethargy throughout the experiment. Postmortem examination of moribund fish revealed body darkness with excessive mucus secretion and paled liver with red patches. In addition, this group showed a mortality rate reached 18.66%. Dietary supplementation of 1.5% thyme and 1% rosemary for 6 weeks of feeding exhibited a little bit of cytogenetic effect on peripheral blood, head kidney, and liver tissue, as the recorded types of aberrations were not severe. Fish receiving 1% rosemary for 6 weeks showed significant increases in the activity of hepatic enzymes, CPK and LDH activities, as well as creatinine levels, compared to the control and other treated groups. The results of this study demonstrate that, although thyme and rosemary have beneficial effects as medicinal herbs, they may pose cytogenetic threats to cells of the Nile tilapia at an early life stage. Thyme at a dose of 1% was proven to be safe for the juvenile Nile tilapia.
How do trade unions manage themselves? A study of Australian unions’ administrative practices

Dedication We gratefully acknowledge the invaluable contributions to the research that we discuss here by our dear friend and colleague the late Dr Sandra Cockfield; we miss her greatly. We dedicate this article to her. For a tribute to her see www.monash. edu/vale/home/articles/vale-dr-sandra-cockfield. The article discusses issues rarely addressed in research on Australian unions: the internal management policies and practices of unions, including human resource management, budgeting and strategy formulation. Management matters because it creates processes and systems that focus activity on whatever objectives a union or other organisation wishes to achieve. Our main research question is ‘how do Australian unions manage their employees, budgets, and strategies? ’ Our study builds on earlier studies of US, UK and Canadian unions by adapting a survey instrument used in these countries. The Australian Council of Trade Unions (ACTU) asked national and branch unions to complete our online surveys. Of the unions surveyed, a majority of respondents use systematic human resource management policies and practices. They have also adopted strategic planning and budgeting practices. Echoing international findings, Australian unions have increasingly professionalised their administration. These findings are important since they have implications for how Australian unions deal with the challenges they face, including their revitalisation efforts and their responses to changing regulatory contexts.
Left Ventricular Diastolic Function: Comparison of Slow Coronary Flow Phenomenon and Left Ventricular Hypertrophy in the Absence of Obstructive Coronary Disease

Background An interplay of myocardial structural abnormalities and coronary arterial dysfunction underlies the worsening left ventricular compliance. The conventionally used angina drugs have demonstrated a beneficial effect on both angina and coronary flow in cases with microvascular dysfunction and non-obstructive coronary disease. Despite that, vasoactive therapy only partially affects diastolic function in this patient population. Purpose This retrospective study was planned to evaluate the association of myocardial mass, delayed epicardial coronary flow, and vasoactive drugs with parameters of diastolic function in two cohorts with preserved left ventricular function and non-obstructive coronary disease in patients with slow coronary flow phenomenon (SCFP) and patients with the hypertensive disease and left ventricular hypertrophy. Material and methods The epicardial coronary flow was evaluated in 48 patients with unstable angina in the absence of coronary stenosis >50%, by applying the methods of corrected thrombolysis in myocardial infraction frame count (cTFC). The abnormalities in the left ventricular function were assessed by echocardiography using PW-Doppler of the diastolic mitral inflow and tissue Doppler imaging. Twenty-one (43.8%) patients were diagnosed with SCFP, and twelve patients (25%) had slow epicardial coronary flow, hypertensive disease, and ventricular hypertrophy (SFLVH). The remaining 15 (31.3%) were patients with ventricular hypertrophy, hypertension, and non-delayed epicardial coronary flow (NFLVH). Results The patients with SFLVH showed reduced peak early diastolic lateral mitral annular velocity (e’L) when compared to SCFP (7.1±1.9cm/s vs 8.6±2.1 cm/s, p=0.045) and NFLVH (7.1±1.9 cm/s vs 8.7±1.8 cm/s, p=0.018). A borderline significant difference was observed for the peak early diastolic septal mitral annular velocity (e’S) between the patients with SFLVH and SCFP ( 7.0±1.3 cm/s vs 8.3±2.1 cm/s, p=0.057). The ratio of mitral diastolic inflow velocity to early diastolic velocity of the mitral annulus (E/e’) in the SFLVH group was a tendency higher than E/e’ of the patients with SCFP (9.8±3.1 vs. 8.2±2.1, p=0.084) and NFLVH (9.8±3.1 vs. 7.8±1.5, p=0.051) . In the group with left ventricular hypertrophy, E/e’ >10 was more frequently observed in patients with a marked delay in the epicardial flow (33.1 ± 13.1 frames vs. 25.4 ± 11.8 frames, p=0.011) and higher left ventricular mass (146.9 ± 17.7 g/m2 vs. 126.1 ± 121.5 g/m2, p=0.027). Conclusions Patients with microvascular angina represent a diverse population. The echocardiographic parameters of left ventricular relaxation (e') and end-diastolic pressure (E/e’) are abnormally altered in the population with left ventricular hypertrophy compared to SCFP. The delayed epicardial flow further impairs diastolic function in hypertensive patients with hypertrophy and non-obstructive coronary disease.
Micronutrients and Amino Acids Food Intakes and Their Associations with Obesity, Type 2 Diabetes and Apo B/Apo A1 Ratio in Middle-Aged Algerian Adults

Objective: The present work investigates the interrelationship of food intakes of micronutrients and amino acids with the apolipoprotein (apo) B / apo A1 ratio as a potential indicator of atherosclerosis risk in patients with obesity and/or type 2 diabetes (T2D). Methods: A cross-sectional comparative study was performed on 285 participants divided into three groups; normal-weight type 2 diabetics, overweight/obese type 2 diabetics and overweight/obese non-diabetics. Anthropometric and blood pressure were measured. Biochemical parameters were evaluated and the apo B/apo A1 ratio was calculated. Food dietary intakes were assessed using a validated 3-days food record. The Association between intakes of micronutrients (vitamins and minerals) and amino acids was studied using Principal Component Analysis (ACP). Results: Significant differences were revealed with respect to age, fasting and postprandial blood glucose, triglycerides and glycated hemoglobin (Hba1c) ( p <0.005). In normal-weight diabetics, ACP showed that the highest apo B/apo A1 ratios were positively associated with branched-chain amino acids intake, vitamins E and B 6 , and calcium, zinc and phosphorus levels. In overweight/obese T2D patients, amino acid intakes were associated with vitamins B 2 and B 12 and minerals; phosphorus and zinc. However, results in overweight/obese patients without diabetes revealed that amino acid intakes were specifically correlated with vitamin D. Conclusion: Micronutrients and amino acids play a pivotal role in the development of cardiovascular risk in obese and/or diabetics. Branched-chain amino acids, B and D vitamins, as well as calcium and zinc, show considerable associations with higher apo B/apo A1 ratio and therefore with atherosclerosis.
Covid-19 e Saúde Mental de Universitários: Revisão Integrativa Internacional

Este artigo apresenta uma revisão integrativa sobre a produção científica internacional a respeito dos impactos da pandemia por covid-19 na saúde mental de estudantes universitários. Foram analisados 44 artigos encontrados nos bancos de dados LILACS, PubMed, PsycInfo e SciElo, em que se evidencia que a covid-19 tem causado piora significativa na saúde mental da comunidade acadêmica, em todo o mundo, gerando, principalmente, sintomas moderados e graves de ansiedade e depressão. Faz-se necessário que as instituições de ensino superior tenham conhecimento a respeito deste fato e criem mecanismos de escuta e suporte psíquico para propiciar melhores condições de enfrentamento da condição atual.