Miracle-dz/UniFAR-FTUs huggingface dataset:
The Appropriateness of Empirical Antimicrobial Treatment of Uncomplicated Urinary Tract Infection in Adult Female Patients in Jazan Region, Saudi Arabia

Introduction: Uncomplicated urinary tract infection (uUTI) is one of the most prevalent bacterial infections in clinical practice. Empirical treatment is used commonly; thus, knowledge of the local antimicrobial susceptibility pattern is crucial to avoid the growing antibiotic resistance. Purpose: The aim of this study is to evaluate the effectiveness of the empirical treatment of uUTI and determine the susceptibility pattern for common uUTI causative microorganisms at outpatient clinics in hospitals in the Jazan region. Method: This is a prospective observational study of 120 patients with uncomplicated urinary tract infections attending internal medicine outpatient clinics in Al-Hayat Jazan hospital, Saudi Arabia, from September 2021 to January 2023. Results: In total, 120 patients were included in the study. The mean age of the participants was 48.53 ± 9.29. Risk factors for UTI were found in 57.5%, and type 2 diabetes mellitus (DM) was the major risk factor (27.5%). The most common causative microorganism was Escherichia coli (E. coli) (87.5%), followed by Klebsiella pneumoniae (5%), Staphylococcus aureus, Enterobacter spp. , and Enterococcus spp. (2.5%). Nitrofurantoin was the most effective antimicrobial agent (sensitivity rate of 91.7%) against all microorganisms, followed by Ciprofloxacin (75%). Conclusions: This study concluded that nitrofurantoin and Ciprofloxacin are suitable empirical treatments for uncomplicated urinary tract infection in the Jazan region, and increased resistance against trimethoprim/sulphamethoxazole (TMPSMX) and cefaclor was observed; thus, empirical therapy with these agents should be reconsidered in local guidelines. Wide surveillance research is necessary to monitor effective empirical therapies and to evaluate the regional antimicrobial susceptibility pattern.
Risk and bank financial performance in Kuwait

The purpose of this study is to examine the effect of risk factors on the financial performance of Kuwaiti banks. The study based on the financial data of ten banks listed at Kuwait stock exchange (KSE) over the period 2008-2018. Return on assets (ROA) is used as the proxy of financial performance and operational risk, credit risk and liquidity risk as risk factors. Results of the research shows that the financial performance of Kuwaiti banks is mostly affected by operational risk and liquidity risk and that credit risk does not have any statically significant effect of their financial performance.
The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer

Until recently, Deltex (DTX) proteins have been considered putative E3 ligases, based on the presence of an E3 RING domain in their protein coding sequence. The human DTX family includes DTX1, DTX2, DTX3, DTX3L and DTX4. Despite the fact that our knowledge of this class of E3-ubiquitin ligases is still at an early stage, our understanding of their role in oncogenesis is beginning to unfold. In fact, recently published studies allow us to define specific biological scenarios and further consolidate evidence-based working hypotheses. According to the current evidence, all DTX family members are involved in the regulation of Notch signaling, suggesting a phylogenetically conserved role in the regulation of this pathway. Indeed, additional evidence reveals a wider involvement of these proteins in other signaling complexes and cancer-promoting mechanisms beyond NOTCH signaling. DTX3, in particular, had been known to express two isoform variants (DTX3a and DTX3b). The recent identification and cloning of a third isoform variant in cancer (DTX3c), and its specific involvement in EphB4 degradation in cancer cells, sheds further light on this group of proteins and their specific role in cancer. Herein, we review the cumulative knowledge of this family of E3 Ubiquitin ligases with a specific focus on the potential oncogenic role of DTX isoforms in light of the rapidly expanding findings regarding this protein family’s cellular targets and regulated signaling pathways. Furthermore, using a comparative and bioinformatic approach, we here disclose a new putative motif of a member of this family which may help in understanding the biological and contextual differences between the members of these proteins.
Assessment of block-wise status of micro nutrients in some soils of Shivalik hills of Himachal Pradesh

The investigation was undertaken and micro nutrients status of the area was assessed. During February-March 2020, 50 soil sampling locations from tomato growing areas were selected at random and 100 representative surface (0-15 cm) and sub-surface (15-30 cm) soil samples were collected. Various micronutrients, i.e. DTPA-extractable Zn, Cu, Mn and Fe were examined. The soils were neutral to slightly alkaline, and the EC values of all the soil samples were within normal limits. The general state of the soil organic carbon concentration was medium to high. The DTPA- Mn, Fe, Cu and Zn in soils of the studied area were found to be in medium category. Positive correlations between the DTPA-extractable iron, copper, zinc and manganese with the organic carbon content was observed.
Exploring the Relationship between Interpersonal Empathy, Social Empathy, and Racial Attitudes

Abstract Diversity initiatives have become pervasive within social service agencies, despite evidence of mixed outcomes for marginalized groups. Social empathy is a construct that may have the potential to improve intergroup outcomes. Social empathy is a framework that emphasizes macro-level perspective-taking as well as contextual understanding of systemic barriers for marginalized groups. In general, multiculturally focused initiatives have seen better success for intergroup outcomes than those based on colorblind ideologies. To explore social empathy’s ability to promote positive intergroup outcomes, this study investigated the relationship between the different facets of interpersonal and social empathy and these two contrasting racial attitudes. Cross-sectional surveys were administered to two different study samples: U.S. adults (n = 475) and students enrolled in a large public university (n = 290). As hypothesized, social empathy was key in predicting both racial attitudes across both samples in multiple regression models. The aspect of social empathy known as contextual understanding of systemic barriers showed the largest effects and was negatively associated with colorblind and positively associated with multicultural attitudes. Interpersonal empathy was largely unrelated to either racial attitude. Future research should examine whether interventions aimed at increasing social empathy can improve intergroup outcomes in social service settings.
Alterações clínico-patológicas, diagnóstico sorológico e molecular em cães com suspeita de leptospirose

A leptospirose é uma zoonose de importância mundial que causa mortes tanto em humanos, como em animais, especialmente em cães não vacinados. A infecção em cães ocorre pelo contato com urina ou água contaminada pela bactéria espiroqueta patogênica do gênero Leptospira. Objetivou-se avaliar dois testes diagnósticos na caracterização de cães com leptospirose, e associar com as principais alterações clínicos-patológicas de cães suspeitos. Foram atendidos no Hospital Veterinário da Universidade Federal de Uberlândia no período de setembro de 2019 a setembro de 2020, 24 cães com suspeita clínica de leptospirose canina. Exames complementares como hemograma completo, dosagens séricas de creatinina, ureia, ALT (alanina aminotransferase), FA (fosfatase alcalina) foram solicitados. Para o diagnóstico confirmatório de leptospirose foi realizado teste sorológico pelo teste de aglutinação microscópica (MAT) e também teste molecular pela reação em cadeia da polimerase em tempo real (qPCR). Dos 24 casos de cães suspeitos de leptospirose, seis (25%) foram positivos no MAT, e três (12,5%) no qPCR, sendo 1 (um) (4,17%) positivo nos dois testes diagnósticos avaliados. Quando se associou MAT + qPCR a positividade foi para 8/24 (33,3%). Os sorogrupos reativos predominantes foram Icterohaemorrhagiae (33,33%) e Djasiman (33,33%), seguido de Ballum (16,60%). A sensibilidade e especificidade da qPCR em relação teste padrão ouro (MAT) foi 16,7 % e 88,9%, respectivamente. Houve alterações nos níveis séricos de creatinina, ureia e FA no grupo positivo aos testes diagnósticos (MAT/qPCR), porém somente ureia e FA apresentaram valores elevados no grupo negativo. Quando se comparou os parâmetros bioquímicos no grupo positivo aos testes diagnósticos (MAT/qPCR), e negativo, não se observou nenhuma diferença estatística significativa entre os elementos avaliados (p>0,05). Conclui-se para o diagnóstico de leptospirose canina aguda, o médico veterinário deve associar os achados clínicos-patológicos aos resultados do MAT de forma pareada e o qPCR de urina.
Long-Term Physical Activity Effectively Reduces the Consumption of Antihypertensive Drugs: A Randomized Controlled Trial

Background: Although physical activity (PA) has been shown to enhance hypertension control, the impact of exercise on the potential decrease of the use of antihypertensive medications remains inadequately researched. Aim: The aim was to assess the impact of a two-year PA on the medication requirements of individuals with hypertension. Methods: A clinical trial was conducted, involving 130 participants with essential hypertension who took at least one antihypertensive medication. Participants were randomly assigned to either a control group (CG n = 65) or an experimental group (EG n = 65) that underwent a 24-month supervised PA program based on a combination of aerobic and resistance training. The antihypertensive drug load for each participant was determined by adding the ratios of the prescribed daily dose (PDD) to the defined daily dose (DDD) for all antihypertensive medications taken by the participants. The outcome measures were evaluated at 0, 6, 12, 18, and 24 months. Results: A total of 76 participants completed the 24-month assessment, and RM-ANOVA revealed a significantly lower antihypertensive drug load in the EG compared to the CG at 18 (p < 0.017) and 24 months (p < 0.003). Conclusion: A long-term PA program can decrease the antihypertensive drug load in older adults with essential hypertension. The trend of improvement regarding the EG drug load intake and the trend of CG drug load increase, although not significant over time, results in a significant difference between the groups at 18 months and an even greater difference at 24 months. This trend certifies the protective value of PA against the aging process and its related health risk factors.
A New Method to Correct Radiosonde Temperature Biases Using Radio Occultation Data

AbstractA new method to estimate radiosonde temperature biases using radio occultation measurements as a reference has been developed. The bias is estimated as the difference between mean radio occultation and mean radiosonde departures from collocated profiles extracted from the Met Office global numerical weather prediction (NWP) system. Using NWP background profiles reduces the impact of spatial and temporal collocation errors. The use of NWP output also permits determination of the lowest level at which the atmosphere is sufficiently dry to analyze radio occultation dry temperature retrievals. The authors demonstrate the advantages of using a new tangent linear version of the dry temperature retrieval algorithm to propagate bending angle departures to dry temperature departures. This reduces the influence of a priori assumptions compared to a nonlinear retrieval. Radiosonde temperature biases, which depend on altitude and the solar elevation angle, are presented for five carefully chosen upper-air sit.
Characterization of breast density in Vietnam and its association with demographic, reproductive and lifestyle factors

This study aims to investigate patterns of breast density among women in Vietnam and their association with demographic, reproductive and lifestyle features. Mammographic densities of 1,651 women were collected from the two largest breast cancer screening and treatment centers in Ha Noi and Ho Chi Minh city. Putative factors associated with breast density were obtained from self-administered questionnaires which considered demographic, reproductive and lifestyle elements and were provided by women who attended mammography examinations. Results show that a large proportion of Vietnamese women (78.4%) had a high breast density. With multivariable logistic regression, significant associations of high breast density were evident with women with less than 55 years old (OR=3.0), having BMI less than 23 (OR=2.2), experiencing pre-menopausal status (OR=2.9), having less than three children (OR=1.7), and being less than 32 years old when having their last child (OR=1.8). Participants who consumed more than two vegetable servings per day also had an increased risk of higher density (OR=2.6). The findings suggest some unique features regarding mammographic density amongst Vietnamese compared with westernized women.
Pharmacological actions of Euphorbia hirta: A review

Euphorbiaceae is the family of Euphordia hirta. It is istributed throughout the indo-pak subcontinent, often found in waste places along the roadsides. The plant parts are widely used in traditional system of medicines, in the treatment of respiratory diseases, gastrointestinal disorders, wound healing, pulmonary disorders, urinogenital disorders, tumors, lactation in women etc. The plant has also been used as anti-inflammatory, antioxidant, antitumour, antidiabetic and free radical scavenging, anti allergic, analgesic and antianaphylactic, antioxytic, sedative, antiarthritic, antidiarrhoeal, spasmogenic, antithrombocytopenic, diuretic, GI tract, burn wound healing, immune stimulatory, sperm motility
Pure quantile portfolios on the Johannesburg stock exchange

Abstract Rules-based portfolio sorts are commonplace for the evaluation of style anomalies. An unfortunate consequence of constructing portfolios on a target style is the unintended loading on non-target factors. A plausible approach is the application of optimisation to maintain target factor loading while minimising non-target factor exposures. We test this methodology on an emerging market bourse, the Johannesburg Stock Exchange, via quintile portfolios sorted on momentum, value and size. We find that value and momentum benefit most from optimisation in terms of nominal and risk-adjusted performance. From an emerging market perspective, we show that optimisation is a viable alternative when independent sorts are infeasible.
The Relationship between Parent-Offspring Communication and the School Adaptation of Leftover Children in Overseas Countries: The Mediating Role of Companionship and the Moderating Role of a Sense of Safety

Background: In the diasporic eastern coastal region of China, leftover children are a unique group of children; their social adaptation challenges are more prominent due to transnational separation from parents. This study explores the relationship between parent-offspring communication and school adaptation among leftover children. Methods: We administered questionnaires to 957 children from six schools in June and December of 2022. All students in the sample were randomly selected from within the classrooms. In total, 561 (47.95% female, mean age = 12.84, SD = 0.95) of them were leftover children. Self-report questionnaires on communication with their parents, school adaptation, companionship, and feelings of safety were used in this investigation We subsequently used SPSS software and the PROCESS plugin to analyze the relationships between variables. Results: A significant and positive relationship was found between parent-offspring communication and school adaptation in leftover children. Companionship mediated this effect. Additionally, the impact of parent-offspring communication on companionship was moderated by a sense of safety. Conclusions: The study concluded that parent-offspring communication, school adaptation, companionship, and a sense of safety were all positively correlated. In addition, companionship partially mediated the relationship between parent-offspring communication and school adaptation. Moreover, a sense of safety played a moderating role. These conclusions can provide empirical support for improving the school adaptation of leftover children.
Parasitoids and pathogens in a collapsing Lymantria dispar (Lepidoptera: Erebidae) population in Lower Austria

A local population outbreak of the spongy moth, Lymantria dispar L. (Lepidoptera: Erebidae), in Lower Austria, resulted in the defoliation of an oak forest in 2018 and 2019. In the study year 2020, the population density was still high but was expected to decline. In the present work, the role of parasitoids and pathogens in the collapse of the population was investigated. In total, 20 egg masses, 680 larvae and 12 pupae of L. dispar were collected in the field from April to July 2020 and reared until the emergence of adult moths or death. Causes of mortality were determined based on emerging parasitoids and on microscope inspection of non‐parasitized cadavers. Stage‐specific mortality rates were calculated for eggs, larval stages (L1–L6) and pupae. Seven parasitoid species and three pathogens were responsible for the premature death of spongy moths. The egg parasitoid Anastatus disparis (Hymenoptera: Eupelmidae) emerged from 19% of all eggs. Larval parasitoids caused stage‐specific mortality rates from 15% to 61%. The dominant parasitoid of young and intermediate instars was the solitary wasp Glyptapanteles porthetriae (Hymenoptera: Braconidae). Mature larvae were mainly parasitized by the parasitic flies Blepharipa pratensis (Diptera: Tachinidae) and Parasetigena silvestris (Diptera: Tachinidae). Pathogens caused stage‐specific mortality rates from 11% to 41%. The nuclear polyhedrosis virus (LdNPV; Lefavirales: Baculoviridae) was the dominant pathogen in all instars. The introduced fungus Entomophaga maimaiga (Entomophthorales: Entomopthoraceae)—detected for the first time in Austria in 2019—caused low mortality rates in older larvae. Starting from high egg mass densities in spring, the spongy moth population declined to negligible levels until summer.
Opinion Propagation Over Signed Networks: Models and Convergence Analysis

In this paper, we consider the propagation problem of multiple competing opinions over a network with antagonistic interactions, modeled as a signed graph. The sign attached to an edge in this graph characterizes the cooperative (positive edge) or antagonistic (negative edge) relation between agents. The agent randomly selects itself or one of its neighbors to determine its opinion. If the agent selects itself, it will stick to its own opinion; if the agent selects the neighbor that interacts with it in the cooperative way, it will adopt the neighbor's opinion. However, for the antagonistic interaction, the agent chooses one opinion from the competing opinions, subtracting its neighbor's opinion in nonuniform and uniform probability, respectively. According to the update rules established earlier, two propagation models are provided. For the nonuniform scenario, a new network is constructed and its connection with the signed network is illuminated. Taking advantage of this connection, a graph condition is proposed for the propagation model to converge. For the uniform scenario, necessary and sufficient conditions in terms of network topology are derived, which guarantee the convergence of the propagation model. Furthermore, if the signed network is structurally balanced, complementary probabilities will be achieved on the same opinion by the bipartite subgroups.
Multiplier projections on spaces of real analytic functions in several variables

Abstract Let be open with . We characterize the sets having the following property: for every real analytic function f on with Taylor expansion at zero, the series is also the Taylor expansion at zero of some real analytic function on . This result gives a characterization of the idempotents in the algebra of Hadamard-type operators on the space of all real analytic functions , i.e. operators with all monomials being eigenvectors. In many cases, we also describe the multiplicative functionals on and the (continuous) algebra homomorphisms . We show that the algebra is never locally m-convex and in many cases it is not a Q-algebra.
Three-dimensional Teleconnections in the Zonally Asymmetric Height Field During the Northern Hemisphere Winter

In order to discuss three-dimensional teleconnection in the zonally asymmetric height field during the Northern Hemisphere winter, the so-called one-point correlation map is used. In the map, the correlation coefficient between 700mb zonally asymmetric height at the base grid point and *-mb (*: pressure) zonally asymmetric height at every other grid point is computed, based on the data set of monthly mean height for 30 winter months (Decembers, Januarys and Februarys for the 10 winters 1969-70 through 1978-79). The discussion is mainly forcused on the case where the base grid point is (45*N, 135*E) at 700mb level over the northern part of Japan. The results show that there is a strong teleconnection in the troposphere between the northern part of Japan and the western part of Barents Sea (or the northern part of Norwegian Sea), and the 700mb zonally asymmetric height over the northern part of Japan is highly correlated in the negative sense with the 200mb zonally asymmetric height over the subtropical western Pacific Ocean. The teleconnection mentioned above is discussed in relation to the standing wave of geopotential height of zonal wave number 1 and this standing wave is examined as the response of a model atmosphere to forcing by topography and stationary heat sources in the atmosphere. The teleconnection with lag time in the zonally asymmetric height field and the zonally symmetric seesaw in the geopotential height field are also discussed.
Performance evaluation of proposed component based model in software reusability

In software engineering there is need for developing and using paradigms that will significantly promote decreased effort in developing software products, increased quality of software products and decreased time-to-markets. Software reuse has been a buzz word in large companies for some time now, with its potential for achieving good quality systems in short time scales by the reuse of currently available components. Decreased effort and increased quality will decrease the overall cost of software and also decrease the time-to-market of the software. An effort has been made in this paper to introduce component based model for software reusability. Software metrics have been used to identify potential of the system used