Miracle-dz/UniFAR-FTUs huggingface dataset:
A weak Harnack inequality for stochastic partial differential equations

We consider linear stochastic partial differential equations under minimal assumptions: the coefficients are merely bounded and measurable and satisfy the stochastic parabolicity condition. We derive local supremum estimates with a stochastic adaptation of De Giorgi's iteration and establish a weak Harnack inequality for the solutions. The latter is then used to obtain pointwise almost sure continuity.
Accelerating the Development and Validation of Liquid Biopsy for Early Cancer Screening and Treatment Tailoring

Liquid biopsy (LB) is a minimally invasive method which aims to detect circulating tumor-derived components in body fluids. It provides an alternative to current cancer screening methods that use tissue biopsies for the confirmation of diagnosis. This paper attempts to determine how far the regulatory, policy, and governance framework provide support to LB implementation into healthcare systems and how the situation can be improved. For that reason, the European Alliance for Personalised Medicine (EAPM) organized series of expert panels including different key stakeholders to identify different steps, challenges, and opportunities that need to be taken to effectively implement LB technology at the country level across Europe. To accomplish a change of patient care with an LB approach, it is required to establish collaboration between multiple stakeholders, including payers, policymakers, the medical and scientific community, and patient organizations, both at the national and international level. Regulators, pharma companies, and payers could have a major impact in their own domain. Linking national efforts to EU efforts and vice versa could help in implementation of LB across Europe, while patients, scientists, physicians, and kit manufacturers can generate a pull by undertaking more research into biomarkers.
Molecular Simulation of Fracture Dynamics of Symmetric Tilt Grain Boundaries in Graphene

Atomistic simulations were utilized to obtain microscopic information of the elongation process in graphene sheets consisting of various embedded symmetric tilt grain boundaries (GBs). In contrast to pristine graphene, these GBs fractured in an extraordinary pattern under transverse uniaxial elongation in all but the largest misorientation angle case, which exhibited intermittent crack propagation and formed many stringy residual connections after quasi mechanical failure. The strings known as monoatomic carbon chains (MACCs), whose importance was recently highlighted, gradually extended to a maximum of a few nanometers as the elongation proceeded. These features, which critically affect the tensile stress and the shape of stress-strain curve, were observed in both armchair and zigzag-oriented symmetric tilt GBs. However, there exist remarkable differences in the population density and the achievable length of MACCs appearing after quasi mechanical failure which were higher in the zigzag-oriented GBs. In addition, the maximum stress and ultimate strain for armchair-oriented GBs were significantly greater than those of zigzag-oriented GBs in case of the largest misorientation angle while they were slightly smaller in other cases. The maximum stress was larger as the misorientation angle increased for both armchair and zigzag-oriented GBs ranging between 32~80 GPa, and the ultimate strains were between 0.06~0.11, the lower limit of which agrees very well with the experimental value of threshold strain beyond which mechanical failure often occurred in polycrystalline graphene.
Vermiculite and shading in the formation of 'Rangpur' lime rootstock

‘Rangpur’ lime (Citrus limonia Osbeck cv. Cravo) is widely used as a rootstock for citrus seedlings, although factors such as luminosity and substrate composition are extremely important to obtain quality seedlings. The objective of this study was to analyze the formation of ‘Rangpur’ lime seedlings grown in different substrates and luminosities. A 3x4 factorial arrangement was used in an RBD with four replications of twelve plants. Three luminosities (full sun, 35%, and 70% shading) and four substrate: vermiculite proportions were tested (S1-1: 0, S2-2: 1, S3-1: 2, and S4-0: 1). The seeds were sown in 280 cm3 tubes and emergence was evaluated every two days for 30 days, and biometric assessments at 30, 60, 90, and 120 DAE by measuring the height, diameter, leaves, and mortality. Root length and shoot and root dry mass were measured at 30 and 120 days. Seeds in full sun showed high ESI values and a shorter time period, as well as high mortality at 120 DAE. Highly shaded environments cause etiolation and reduce biomass accumulation and the DQI. Seeds in S4 showed lower results for most variables. It is recommended to use 35% shading associated with the substrate proportions S1, S2, and S3.
Basic Modeling of the Solar Atmosphere and Spectrum

This grant supported the research and publication of a major 26-page paper in The Astrophysical Journal, by Fontenla, Avrett, & Loeser (2002): 'Energy Balance in the Solar Transition Region. IV. Hydrogen and Helium Mass Flows with Diffusion. ' This paper extended our previous modeling of the chromosphere-corona transition region to include cases with particle and mass flows. Inflows and outflows were shown to produce striking changes in the profiles of hydrogen and helium lines. An important conclusion is that line shifts are much less significant than the changes in line intensity and central reversal due to the influence of flows on the excitation and ionization of atoms in the solar atmosphere. This modeling effort at SAO is the only current one being undertaken anywhere to simulate in detail the full range of non-LTE absorption, emission, and scattering processes in the solar atmosphere to account for the entire solar spectrum from radio waves to X-rays. This effort is being continued with internal SAO funding at a relatively slow pace. Further NASA support in the future would yield results of great value for the interpretation of solar observations from NASA spacecraft.
A glimpse into ancient food storage: Sequestrichnia and associated nucleocave Chondrites from Eocene deep-sea deposits

A glimpse into ancient food storage: Sequestrichnia and associated nucleocave Chondrites from Eocene deep-sea deposits. Acta Palaeontologica Polonica 67 (3): 767–779. The old brickyard Velká nad Veličkou in the Czech Republic offers a unique insight into an Eocene deep-sea ichno assemblage that is dominated by sequestrichnia. Secondary use of such food-stowing was made by the tracemaker of Chondrites intricatus as evidenced by its frequent penetration of the trace fossil Zoophycos brianteus and its occurrence preferentially on the surface of Zoophycos spreiten. Here, the Chondrites tracemaker presumably exploited the nutrient-enriched micro-environment (nucleocave). This close interrelations between Chondrites and Zoophycos support the hypothesis of a sequestrichnial behaviour of the Zoophycos producer. The studied locality also yields Helminthopsis tenuis, Planolites
Effect of Irrigation and Nitrogen Levels on Nutrient Uptake, Water Use Efficiency and Productivity of Onion (Allium cepa L.) in Himachal Pradesh

Onion is an important crop of Himachal Pradesh, but the productivity of the crop is quite low owing to lack of assured availability of irrigation water, sub optimal and imbalanced use of fertilizer nutrients, improper management of soil and water resources and inadequate crop management practices, weed control and plant protection measures, etc. Among various factors involved, nutrient and moisture supply are important inputs for realizing higher onion yield. Irrigation scheduling is a critical management input to ensure optimum soil moisture regime for proper growth and development as well as for optimum yield and economic benefits. Well managed irrigation can lead to increased yields, greater farmer profit, and significant water savings, reduced International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 02 (2019) Journal homepage: http://www.ijcmas. com
Al-Decorated C2N Monolayer as a Potential Catalyst for NO Reduction with CO Molecules: A DFT Investigation

Developing efficient and economical catalysts for NO reduction is of great interest. Herein, the catalytic reduction of NO molecules on an Al-decorated C2N monolayer (Al-C2N) is systematically investigated using density functional theory (DFT) calculations. Our results reveal that the Al-C2N catalyst is highly selective for NO, more so than CO, according to the values of the adsorption energy and charge transfer. The NO reduction reaction more preferably undergoes the (NO)2 dimer reduction process instead of the NO direct decomposition process. For the (NO)2 dimer reduction process, two NO molecules initially co-adsorb to form (NO)2 dimers, followed by decomposition into N2O and Oads species. On this basis, five kinds of (NO)2 dimer structures that initiate four reaction paths are explored on the Al-C2N surface. Particularly, the cis-(NO)2 dimer structures (Dcis-N and Dcis-O) are crucial intermediates for NO reduction, where the max energy barrier along the energetically most favorable pathway (path II) is as low as 3.6 kcal/mol. The remaining Oads species on Al-C2N are then easily reduced with CO molecules, being beneficial for a new catalytic cycle. These results, combined with its low-cost nature, render Al-C2N a promising catalyst for NO reduction under mild conditions.
Efficient Inference with Poor Instruments: a General Framework

We consider a general framework where weaker patterns of identifcation may arise: typically, the data generating process is allowed to depend on the sample size. However, contrary to what is usually done in the literature on weak identification, we do not give up the efficiency goal of statistical inference: even fragile information should be processed optimally for the purpose of both efficient estimation and powerful testing. Our main contribution is actually to consider that several patterns of identification may arise simultaneously. This heterogeneity of identification schemes paves the way for the device of optimal strategies for inferential use of information of poor quality. More precisely, we focus on a case where asymptotic efficiency of estimators is well-defined through the variance of asymptotically normal distributions. Standard efficient estimation procedures still hold, albeit with rates of convergence slower than usual. We stress that these are feasible without requiring the prior knowledge of the identification schemes.
Effect of Whey Protein Purity on the Characteristics of Algae Oil-Loaded Encapsulates Obtained by Electrospraying Assisted by Pressurized Gas

In this paper, the effect of protein purity in three different whey protein grades on the characteristics of algae oil encapsulates obtained via room-temperature electrospraying assisted by pressurized gas (EAPG) encapsulation process was studied. Three different commercial grades of whey protein purity were evaluated, namely 35, 80, and 90 wt. %. Oil nanodroplets with an average size of 600 nm were homogeneously entrapped into whey protein microparticles 3 µm in size. However, the sphericity and the surface smoothness of the microparticles increased by increasing the protein purity in the grades of whey protein studied. The porosity of the microparticles was also dependent on protein purity as determined by nitrogen adsorption–desorption isotherms, being smaller for larger contents of protein. Interestingly, the lowest extractable oil was obtained with WP35, probably due to the high content of lactose. The peroxide values confirmed the superior protective effect of the protein, obtaining the smallest peroxide value for WP90, a result that is consistent with its reduced porosity and with its lower permeability to oxygen, as confirmed by the fluorescence decay–oxygen consumption method. The accelerated stability assay against oxidation confirmed the higher protection of the WP80 and WP90. In addition, the increased content in protein implied a higher thermal stability according to the thermogravimetric analysis. These results further confirm the importance of the adequate selection of the composition of wall materials together with the encapsulation method.
Fractional Hardy-Sobolev elliptic problems

In this paper, we study the following singular nonlinear elliptic problem \begin{equation}\label{eq:1} \left\{ \begin{array}{ll} \displaystyle (-\Delta)^{\frac \alpha 2} u=\lambda |u|^{r-2}u+\mu\frac{|u|^{q-2}u}{|x|^{s}}\quad &{\rm in }\quad \Omega, \\ \\ u=0 &{\rm on }\quad \partial\Omega, \end{array} \right. \end{equation} where $\Omega$ is a smooth bounded domain in $\mathbb R^N$ with $0\in \Omega$, $\lambda,\mu>0,0<s\leq\alpha$, $(-\Delta)^{\frac \alpha 2}$ is the fractional Laplacian operator with $0<\alpha<2$. We establish existence results of problem \eqref{eq:1} for subcritical, Sobolev critical and Hardy-Sobolev critical cases.
Current landscape of therapeutic EUS: Changing paradigms in gastroenterology practice

Therapeutic EUS has witnessed exponential growth in the last decade, but it has been considered investigational until recently. An increasing body of good-quality evidence is now demonstrating clear advantages over established alternatives, adding therapeutic EUS to management algorithms of complex hepato-pancreato-biliary (HPB) and gastrointestinal (GI) conditions. In this review, the available evidence and clinical role of therapeutic EUS in established and evolving applications will be discussed. A Graphical Summary for each scenario will provide (1) technical steps, (2) anatomical sketch, (3) best-supporting evidence, and (4) role in changing current and future GI practice. Therapeutic EUS has accepted well-established applications such as drainage of symptomatic peripancreatic fluid collections, biliary drainage in failed endoscopic retrograde cholangiopancreatography, and treatment of acute cholecystitis in unfit-for-surgery patients. In addition, good-quality evidence on several emerging indications (e.g., treatment of gastric outlet obstruction, local ablation of pancreatic solid lesions, etc.) is promising. Specific emphasis will be given to how these technical innovations have changed management paradigms and algorithms and expanded the possibilities of gastroenterologists to provide therapeutic solutions to old and emerging clinical needs. Therapeutic EUS is cementing its role in everyday practice, radically changing the treatment of different HPB diseases and other conditions (e.g., GI obstruction). The development of dedicated accessories and increased training opportunities will expand the ability of gastroenterologists to deliver highly effective yet minimally invasive therapies, potentially translating into a better quality of life, especially for oncological and fragile patients.
Acceptability, feasibility, and effectiveness of smartphone‐based delivery of written educational materials in Iranian patients with coronary artery disease: A randomized control trial study

Providing education to patients with coronary artery disease (CAD) is one of the crucial roles of nurses and, there are various education methods for these patients. This study aimed to investigate the acceptability, feasibility, and effectiveness of smartphone‐based delivery (SPBD) of written educational materials in Iranian patients with CAD.
Correlation of PD-L1 expression with toxicities and response in oropharyngeal cancers treated with definitive chemoradiotherapy

Introduction The programmed death receptor ligand 1 (PD-L1) is a cell-surface glycoprotein expressed in tumour cells (TCs) and is also upregulated in tumour infiltrating lymphocytes. The effect of PD-L1 expression on TCs and tumour-infiltrating lymphocytes (TILs) on acute radiation toxicity and response in oropharyngeal squamous cell carcinoma treated with concurrent chemoradiotherapy is less known. Material and methods Squamous cell carcinoma of oropharynx with stage II-IVA (AJCC 8th) were recruited in this prospective observational study. Definitive radiation therapy (RT) of 70 Gray in 35 fractions at 2 Gray per fraction, 5 fractions a week in 2 phases was delivered with concurrent chemotherapy (cisplatin 40 mg/m2 weekly). Patients were assessed weekly for acute toxicities with Radiation Therapy Oncology Group criteria. Response assessment was done at 3 months post RT according to World Health Organization response assessment criteria. The programmed death receptor ligand 1 expression in TCs and TILs was correlated with acute toxicity and survival. Results Of 51 patients, 20 (39.2%) had PD-L1 expression in TCs and 18 (35.3%) in TILs. Patients with PD-L1 expression in TCs had fewer grade ≥ 3 oral mucositis (25% vs. 58%; p = 0.02) and grade ≥ 3 dysphagia (25% vs. 55%; p = 0.046). The programmed death receptor ligand 1-tumour infiltrating lymphocytes positives had lower ≥ 3 grade oral mucositis (22% vs. 58%; p = 0.02) and ≥ 3 grade dysphagia (17% vs. 58%; p = 0.007). Two-year overall and progression-free survival rate for the PD-L1-tumour-positive vs. PD-L1-tumour-negative group was not different (p > 0.5). Conclusions Positive PD-L1 expression is associated with fewer acute radiation toxicities, and this could be used as a potential biomarker.
Using Sentinel-2 Imagery and Machine Learning Algorithms to Assess the Inundation Status of Nebraska Conservation Easements during 2018-2021

Conservation easements (CEs) play an important role in the provision of ecological services. This paper aims to use the open-access Sentinel-2 satellites to advance existing conservation management capacity to a new level of near-real-time monitoring and assessment for the conservation easements in Nebraska. This research uses machine learning and Google Earth Engine to classify inundation status using Sentinel-2 imagery during 2018–2021 for all CE sites in Nebraska, USA. The proposed machine learning approach helps monitor the CE sites at the landscape scale in an efficient and low-cost manner. The results confirmed effective inundation performance in these floodplain or wetland-related CE sites. The CE sites under the Emergency Watershed Protection-Floodplain Easement (EWPP-FPE) had the highest inundated area rate of 18.72%, indicating active hydrological inundation in the floodplain areas. The CE sites under the Wetlands Reserve Program (WRP) reached a mean annual surface water cover rate area of 8.07%, indicating the core wetland areas were inundated periodically or regularly. Other types of CEs serving upland conservation purposes had a lower level of inundation while these uplands conservation provided critical needs in soil erosion control. The mean annual surface water cover rate is 0.96% for the CE sites under the Grassland Reserve Program (GRP). The conservation of the CEs on uplands is an important component to reduce soil erosion and improve downstream wetland hydrological inundation performance. The findings support that the sites with higher inundation frequencies can be considered for future wetland-related conservation practices. The four typical wetland-based CE sites suggested that conservation performance can be improved by implementing hydrological restoration and soil erosion reduction at the watershed scale. The findings provided robust evidence to discover the surface water inundation information on conservation assessment to achieve the long-term goals of conservation easements.
Effect of Inflation, Exchange Rates, and Interest Rates on Financial Sector Share Prices

The financial sector share price has a high performance on the Indonesia Stock Exchange during 2010-2020. This condition indicates that investors have an interest in companies in the financial sector. This research aims to find out the effect of inflation, exchange rates, and interest rates on the stock prices of the financial sector. The study uses a quantitative approach, research data used during the years 2010-2020. Processing data uses reviews applications that first use classic assumption tests and multiple regressions. The research showed that simultaneously inflation, interest rates, and exchange rates affect stock prices, while partially showed that exchange rates have a positive effect on stock prices, interest rates negatively affect stock prices, while inflation does not affect stock prices. This research model shows an effect on the stock price by 78%.
Micro- and Nanoplastics’ Effects on Protein Folding and Amyloidosis

A significant portion of the world’s plastic is not properly disposed of and, through various processes, is degraded into microscopic particles termed micro- and nanoplastics. Marine and terrestrial faunae, including humans, inevitably get in contact and may inhale and ingest these microscopic plastics which can deposit throughout the body, potentially altering cellular and molecular functions in the nervous and other systems. For instance, at the cellular level, studies in animal models have shown that plastic particles can cross the blood–brain barrier and interact with neurons, and thus affect cognition. At the molecular level, plastics may specifically influence the folding of proteins, induce the formation of aberrant amyloid proteins, and therefore potentially trigger the development of systemic and local amyloidosis. In this review, we discuss the general issue of plastic micro- and nanoparticle generation, with a focus on their effects on protein folding, misfolding, and their possible clinical implications.
Comparing Intraperitoneal and Intravenous Personalized ErbB2CAR-T for the Treatment of Epithelial Ovarian Cancer

High-grade serous ovarian carcinoma (HGSOC) is the most common type of epithelial ovarian cancer. The majority of cases are diagnosed at advanced stages, when intraperitoneal (IP) spread has already occurred. Despite significant surgical and chemotherapeutic advances in HGSOC treatment over the past decades, survival rates with HGSOC have only modestly improved. Chimeric antigen receptor (CAR)-T cells enable T cells to directly bind to tumor-associated antigens in a major histocompatibility complex-independent manner, thereby inducing tumor rejection. While CAR-T cell therapy shows great promise in hematological malignancies, its use in solid tumors is limited. Therefore, innovative approaches are needed to increase the specificity of CAR-modified T cells against solid tumors. The aim of this study was to assess the efficacy and safety of intraperitoneal (IP) versus intravenous (IV) CAR-T cell therapy in the treatment of HGSOC. We constructed a CAR that targets the ErbB2/HER2 protein (ErbB2CAR), which is overexpressed in HGSOC, and evaluated the functionality of ErbB2CAR on ovarian cancer cell lines (OVCAR8, SKOV3, and NAR). Our findings show that an IP injection of ErbB2CAR-T cells to tumor-bearing mice led to disease remission and increased survival compared to the IV route. Moreover, we found that IP-injected ErbB2CART cells circulate to a lesser extent, making them safer for non-tumor tissues than IV-injected cells. Further supporting our findings, we show that the effect of ErbB2CAR-T cells on primary HGSOC tumors is correlated with ErbB2 expression. Together, these data demonstrate the advantages of an IP administration of CAR-T cells over IV administration, offering not only a safer strategy but also the potential for counteracting the effect of ErbB2CAR in HGSOC. Significance: IP-injected ErbB2CAR-T cells led to disease remission and increased survival compared to the IV route. These findings demonstrate the advantages of IP administration, offering a safe treatment strategy with the potential for counteracting the effect of ErbB2CAR in HGSOC.