Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeting the Immune System for Pulmonary Inflammation and Cardiovascular Complications in COVID-19 Patients

In December 2019, following a cluster of pneumonia cases in China caused by a novel coronavirus (CoV), named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the infection disseminated worldwide and, on March 11th, 2020, the World Health Organization officially declared the pandemic of the relevant disease named coronavirus disease 2019 (COVID-19). In Europe, Italy was the first country facing a true health policy emergency, and, as at 6.00 p.m. on May 2nd, 2020, there have been more than 209,300 confirmed cases of COVID-19. Due to the increasing number of patients experiencing a severe outcome, global scientific efforts are ongoing to find the most appropriate treatment. The usefulness of specific anti-rheumatic drugs came out as a promising treatment option together with antiviral drugs, anticoagulants, and symptomatic and respiratory support. For this reason, we feel a duty to share our experience and our knowledge on the use of these drugs in the immune-rheumatologic field, providing in this review the rationale for their use in the COVID-19 pandemic.
Reduced Ceftazidime-Avibactam Susceptibility in KPC-Producing Klebsiella pneumoniae From Patients Without Ceftazidime-Avibactam Use History – A Multicenter Study in China

KPC-producing Klebsiella pneumoniae (KPC-KP) is the most widely spread carbapenem-resistant Enterobacteriaceae (CRE) in China. Avibactam is a novel non-β-lactam β-lactamase inhibitor which is highly active against KPC. Recently, ceftazidime-avibactam (CAZ-AVI) was approved for clinical treatment in China. Here we conducted a retrospective study to examine the antimicrobial susceptibility of CAZ-AVI prior to its usage in China, and evaluated the potential to develop resistance in KPC-KP. CAZ-AVI MICs were tested in 347 KPC-KP isolates collected from patients with no prior treatment with this combination from six medical centers in China. Almost all isolates (n = 346; 99.7%) were CAZ-AVI-susceptible, with only 12 (3.5%) which showed reduced susceptibility (MIC ≥ 4/4 μg/ml) or resistance. The 12 isolates belong to ST11 and half of them carry virulence genes. In comparison to susceptible isolates, these isolates demonstrated higher blaKPC–2 copy numbers and expressions, and demonstrated higher frequency of developing CAZ-AVI resistance.
Pregnancy Outcomes of Women Conceiving on Antiretroviral Therapy (ART) Compared to Those Commenced on ART During Pregnancy

Abstract Background Globally, the number of infected women of childbearing age living with human immunodeficiency virus (HIV) and conceiving on antiretroviral therapy (ART) is increasing. Evidence of ART safety at conception and during pregnancy and adverse pregnancy outcomes remains conflicting. The Promoting Maternal and Infant Survival Everywhere (PROMISE) 1077 breastfeeding (BF) and formula feeding (FF) international multisite trials provide an opportunity to examine the impact of ART at conception on pregnancy outcomes with subsequent pregnancies. Methods The PROMISE 1077BF/1077FF trials were designed to address key questions in the management of HIV-infected women who did not meet clinical guidelines for ART treatment during the time of the trials. After the period of risk of mother-to-child transmission was over, women were randomized to either continue or discontinue ART. We compared subsequent pregnancy outcomes of nonbreastfeeding women randomized to continue ART following delivery, or breastfeeding women randomized to continue ART following breastfeeding cessation who conceived while on ART to women randomized to discontinue ART, who restarted ART after pregnancy was diagnosed. Results Pregnancy outcomes of 939 subsequent pregnancies of 826 mothers were recorded. The intention-to-treat analyses showed increased incidence of low birth weight (<2500 g) for women who conceived while on ART (relative risk, 2.65 [95% confidence interval {CI}, 1.20–5.81]), and also a higher risk of spontaneous abortion, stillbirth, or neonatal death (hazard ratio, 1.40 [95% CI, .99–1.98]) compared to women who restarted ART after they were found to be pregnant during trial follow-up. Conclusions We found an increased risk for adverse pregnancy outcomes in women conceiving on ART, emphasizing the need for improved obstetric and neonatal care for this group. Clinical Trials Registration NCT01061151.
Clusters for Life or Life Cycles of Clusters: In Search of the Critical Factors of Cluster Resilience

This paper investigates the driving forces behind the life cycles and resilience of technological clusters. It concentrates in particular on the combination of critical parameters that allows clusters to succeed in disconnecting their cycle from the cycle of the technologies they produce, in order to maintain stability and growth in unstable economic environments. Three propositions on location decision externalities, the life cycle of composite technologies, and the structural properties of knowledge networks, are developed and introduced in an inclusive study of cluster trajectories. Discussions show that resilient clusters are the ones that combine network and external audience effects in location decision-making, and evolve towards a specific core/periphery and disassortative structure of knowledge interactions along the knowledge and market phases. Understanding these pathways could be at the heart of the renewal of cluster and regional policy in a macro-economic context characterised by high instability and new growing consumer paradigms.
Growth Regulator Effects of Propiconazole on Redroot Pigweed (Amaranthus retroflexus)1

Nonfungicidal effects of agricultural fungicides on crop plants have been reported previously; however, there are few reports of nontarget effects of fungicides on weedy species. Field research trials in Oregon demonstrated that the growth of several broadleaf weeds was reduced after multiple applications of the fungicide propiconazole. Greenhouse experiments confirmed that preemergence applications of propiconazole reduced the biomass accumulation of several common broadleaf and grass weeds 15 to 63%. Laboratory experiments were performed on redroot pigweed, the most sensitive species, to examine the effects of propiconazole on germination and early seedling growth. Redroot pigweed germination and total seedling length (root plus shoot) were reduced at propiconazole concentrations above 37 and 0.36 mg/L, respectively. Growth-regulating effects of fungicides such as propiconazole on the germination and early growth of weeds may contribute to integrated weed management, especially when adequate moisture ensures the presence of germinating seeds and small seedlings throughout the growing season. Nomenclature: Propiconazole; redroot pigweed, Amaranthus retroflexus L. #3 AMARE. Additional index words: Fungicide, Lolium multiflorum, LOLMU, POAAN, Poa annua, nontarget effects, Senecio vulgaris, SENVU, sterol biosynthesis inhibitor. Abbreviations: DMI, demethylation inhibitor; POST, postemergence; PRE, preemergence; SBI, sterol biosynthesis inhibiting.
Deliberation Enhances the Confirmation Bias: An Examination of Politics and Religion

Existing research has documented the confirmation bias in the domain of politics, but relatively little research has examined the confirmation bias in religion. I developed a novel task in the religious domain and compare confirmation bias evidence to that observed in the political domain. Using a preregistered data collection and analysis plan, I examined data from n=402 participants prescreened by political and religious beliefs. Participants were administered the online task that examined selective information exposure and perceived strength of arguments that are incongruent to one's own beliefs regarding "gun control" and the "existence of God". Results documented a confirmation bias in both information exposure and perceived argument strength. I also examined the hypothesis that the confirmation bias is stronger in situations where more thought or deliberation is brought to bear on the task. The evidence here depends on the measure of deliberation used, but generally supports this hypothesis. For example, the data showed that individuals who have thought a lot about the topic at hand (gun control and the existence of God) displayed a stronger confirmation bias in perceived argument strength than those having thought less about the issue.This paper contributes by offering new evidence documenting the confirmation bias directly compared across domains. And, the findings regarding how deliberation may worsen the bias are in line with previous research suggesting the confirmation bias may be unlike other decision biases — this bias may thrive when the decision maker is more is more deliberative or thoughtful.
Sorbicillinoid Derivatives From Sponge-Derived Fungus Trichoderma reesei (HN-2016-018)

Six new sorbicillinoids, trichoreeseione A (1) and B (2), trichodermolide B (3), 13-hydroxy-trichodermolide (4), 24-hydroxy-trichodimerol (5), 15-hydroxy-bisvertinol (7), together with three known analogs, trichodimerol (6), 24-hydroxy-bisvertinol (8), and bisvertinol (9), were isolated from the sponge-derived fungus Trichoderma reesei (HN-2016-018). Their structures including absolute configurations were elucidated by analysis of NMR, MS data, and calculated ECD spectra. Compounds 1 and 2 with a characteristic naphthalene-trione ring were firstly reported in sorbicillinoid family. Compounds 3 and 4 were two rare sorbicillinoids containing a unique bicycle [3.2. 1] lactone skeleton, while 3 with a propan-2-one moiety was also recorded first time in this family. Compound 5 displayed cytotoxic activity against A549, MCF-7, and HCT116 cell lines with the IC50 values of 5.1, 9.5, and 13.7 μM, respectively.
The Significance of Female Body Stores for Egg Laying and Incubation in Dark-Bellied Brent Geese Branta Bernicla Bernicla

The probability of successful breeding by Brent geese in the Arctic appears to be positively correlated with the mass of females when they depart from spring staging areas in North-western Europe. To clarify the mechanism behind this relationship we investigated the significance of flown-in female body stores for breeding over six summer seasons (1990–1995) in the Pyasina Delta in Taimyr, Russia. Female Brent Geese were caught upon arrival on the breeding grounds. Changes in female body mass and the timing and duration of nest recesses were recorded via electronic weighing platforms placed under their nests. Average female body masses declined through the breeding season; from 1464 g at arrival to 1269 g after egg laying and 1066 g at hatching, which was supposed to be close to lean body mass. Thus half of the stores were used between arrival and clutch completion, the other half during incubation. All females foraged during incubation. On average they left the nest 13.1 times every 24 hours, resulting in a daily recess time of 198 min during the first 21 days of incubation. Females were less likely to leave the nest during the last three days of incubation. Leaving the nest was risky: 40% of the Brent Goose nests in the study area lost one or more eggs to gulls during absence of the female. We estimated that 52% of the energy required during incubation was derived from body stores and the rest (48%) from food intake.
Morphological, anatomical and biochemical characterization of Syrian pear (Pyrus syriaca Boiss) genotypes

Characterization of Syrian pear genotypes was achieved using morphological, anatomical and isozyme markers. Morphological studies discriminated between the six Syrian pear genotypes. Abu-Satel genotype was the most vigorous compared with other genotypes and produced fruits with high quality and quantity. Anatomical studies, depending on leaf thickness and midrib differentiated between the six pear genotypes, especially midrib and vascular bundle thickness. Abu- Satel revealed the highest midrib thickness, while Meskawi genotype revealed the highest vascular bundle thickness. Biochemical markers (isozymes) were used to discriminate between the six pear genotypes using peroxidase and esterase. Peroxidase showed high polymorphism among the six pear genotypes (90%), Abu- Satel revealed the highest number of bands (9 bands), three of which were unique bands, while esterase revealed two monomorphic bands.
Encountering Suffering at Work in Health Religious Organizations: A Partial Least Squares Path Modeling Case-Study

Health religious organizations tend to offer individual attention to patients in line with their spiritual character and, at the same time, the highest service quality. This study puts the attention on the nurse-patient relationship and empirically explores a theoretical model that links nurses’ suffering at work with personal’s willingness to engage in a therapeutic and spiritual relationship with patients and the consequent effect on quality. Data has been collected in the city of Madrid (Spain) in the month of June 2019 in Santa Elena Clinic. An analytical case-study based on Partial Least Squares (PLS) path modeling is the chosen method to verify the cause-effect hypothesized relationships. This study contributes to the current academic literature by providing new knowledge and empirical evidence on the topic of the future of work in health religious organizations. The main conclusion is the necessary inclusion of suffering, even in good places to work, as a key indicator for a better management. Results should be a useful source of information for practitioners that seek to implement better human management systems in these organizations.
The Effects of the War in Iraq on Nutrition and Health: An Analysis Using Anthropometric Outcomes of Children

The war in Iraq initiated in March 2003 triggered a wave of violence and turmoil in the country, exposing households to insecurity and to instability in daily life. The level of violence has varied across provinces, the south and centre areas being the most affected. Using the different intensities of the conflict across areas and the age at exposure to the war among cohorts, I analyze a possible causal effect of the war on nutritional outcomes of children. I use two empirical strategies, leading to very similar results. Estimates indicate that children born in areas affected by high levels of violence are 0.8 cm shorter than children born in low violence provinces. These results are robust to several specifications. Furthermore, the paper also addresses the channels through which the conflict has affected health and nutrition. The results have not only short-term policy implications, but also, given the empirical evidence of the impact of early child malnutrition on later education, labour and productivity outcomes, the results are of great importance for the future.
Phenotypic variation of side-oats grama grass [Bouteloua curtipendula (Michx.) Torr.] collections from the Canadian prairie

Schellenberg, M. P., Biligetu, B. , McLeod, G. J. and Wang, Z. 2012. Phenotypic variation of side-oats grama grass [Bouteloua curtipendula (Michx.) Torr. ] collections from the Canadian prairie. Can. J. Plant Sci. 92: 1043-1048. Native prairie grasses are adapted to local climates and have the potential for development as forage grass cultivars for semiarid environments. Side-oats grama grass [Bouteloua curtipendula (Michx.) Torr. ] is a drought-tolerant grass with desirable forage characteristics, and is distributed across the Canadian prairies and throughout the Great Plains. Understanding ecotypic variability of this species is a prerequisite for developing populations suitable for drier regions of western Canada. A randomized complete block field plot was established using nine seed collections from Manitoba and Saskatchewan in 2006 near Swift Current (lat. 50°25′N, long. 107°44′W), Canada. Seed yield, tiller number, plant height, foliage diameter, and days to flower of individual plants were measured for each collection in the summers of 2007 and 2010. The Sidney and Wolseley collections had taller plants with greater basal diameter. Plants from these two collections also had higher tiller number, and required fewer days to reach flowering stage. However, there was no clear ranking of these variables among other collections. Averaged flowering date was Aug. 15 for Alexander, Sidney, and Wolseley collections, Aug. 21 for Wellwood, Glenboro, and Pratt collections, and Aug. 26 for Minto and Coulter collections, respectively. Taller plants with greater tiller number for the Sidney and Wolseley collections showed a potential for further cultivar development.
Proximate Composition, Color and Nutritional Profile of Raw and Cooked Goose Meat with Different Methods

Proximate composition, color and nutritional profile of raw and cooked goose breast and leg meats were investigated. Water, pH, L* value, total saturated fatty acid (SFA), total polyunsaturated fatty acid (PUFA), Ca, K, Mg, P and Zn contents of leg meat were higher than those of breast meat, while protein, fat, a* value, b* value, total monounsaturated fatty acid (MUFA), Na and Fe contents of breast meat were higher than those of leg meat. pH of breast meat increased with cooking, whereas pH of leg meat decreased. L* and a* values of the samples decreased with cooking, while b* values increased. Cooking caused a decrease in total MUFA content of breast meat, whereas total PUFA content increased. On the other hand, total SFA content of leg meat decreased with cooking, while total MUFA content increased. Cooking caused an increase Ca, Mg, P, Fe and Zn contents of breast meat, while only Fe content of cooked leg meat increased. Practical Applications There is limited information about goose meat in the literature. In addition, to the best of our knowledge, there are no reports on some quality properties of goose meat including fatty acid composition and mineral content and the effect of different cooking methods on them. Therefore, in the present study, we aim to explore some chemical composition (water, crude protein and crude fat), physicochemical properties (pH and color), fatty acid composition and mineral contents of raw and cooked goose meat with different cooking methods.
Developing robust protein analysis profiles to identify bacterial acid phosphatases in genomes and metagenomic libraries.

Phylogenetic analysis of more than 4000 annotated bacterial acid phosphatases was carried out. Our analysis enabled us to sort these enzymes into the following three types: 1) class B acid phosphatases, which were distantly related to the other types, 2) class C acid phosphatases, and 3) generic acid phosphatases (GAP). While class B phosphatases are found in a limited number of bacterial families, which include known pathogens, class C acid phosphatases and GAP proteins are found in a variety of microbes that inhabit soil, fresh water and marine environments. As part of our analysis we developed three profiles, named Pfr-B-Phos, Pfr-C-Phos and Pfr-GAP, to describe the three groups of acid phosphatases. These sequence-based profiles were then used to scan genomes and metagenomes to identify a large number of formerly unknown acid phosphatases. A number of proteins in databases annotated as hypothetical proteins were also identified by these profiles as putative acid phosphatases. To validate these in silico results, we cloned genes encoding candidate acid phosphatases from genomic DNA, or recovered from metagenomic libraries or genes synthesized in vitro based on protein sequences recovered from metagenomic data. Expression of a number of these genes, followed by enzymatic analysis of the proteins, further confirmed that sequence similarity searches using our profiles could successfully identify previously unknown acid phosphatases. This article is protected by copyright. All rights reserved.
Clinical features and prognostic analysis of moyamoya disease associated with intracranial aneurysms

ABSTRACT Objectives To explore clinical features and compare of the difference between conservative treatment and surgical treatmentin prognosis of intracranial aneurysms associated with moyamoya disease (MMD). Methods 104 patients with MMD a ssociated with intracranial aneurysms diagnosed by digital subtraction angiography (DSA) or computed tomography angiography (CTA) were retrospectively analyzed. Results All patients of MMD with intracranial aneurysms had 129 aneurysms distributed at different sites. The distribution of the aneurysms was as follows: 28(21.71%) anterior communicating artery aneurysms, 21(16.28%) basilar artery aneurysms, 19(14.73%) middle cerebral artery aneurysms, 17(13.18%) posterior cerebral artery aneurysms, 12(9.30%)internal carotid artery aneurysms, 11(8.53%) posterior communicating artery aneurysms, 10(7.75%) anterior cerebral artery aneurysms, 5(3.88%) anterior choroidal artery aneurysms, 2(1.55%) moyamoya vessel aneurysms, and 4(3.1%) other location aneurysms. 82 cases (78.85%) had one aneurysm, and 21 cases (20.19%) had 2 or more aneurysms. 64 cases were treated surgically, and 40 cases were treated conservatively. 57 of 81 cases (70.37%) had a good outcome, 2 cases (2.47%) were in paralyzed, and 22 cases were died. The mortality rate was (27.16%). Death occurred in 16 (47.06%) of 34 patients with conservative treatment, and 6(12.77%) of 47 patients with surgical treatment. 7 cases (8.64%) had twice cerebral hemorrhage, and one case (1.23%) had third cerebral hemorrhage in the follow-up period. There were 5 deaths, two good outcomes, and one coma among 8 cases experienced re-hemorrhage. Conclusion Compared with conservative treatment, positive surgical treatment showed clinical significance for preventing cerebral hemorrhage and reducing mortality of MMD with intracranial aneurysms. Abbreviations MMD: moyamoya disease; DSA: digital subtraction angiography; CTA: computed tomography angiography
Gene action of yield and yield contributing characters in chilli (Capsicum annum L.)

Gene action of yield and yield contributing traits in Chilli (Capsicum annuum L.) was studied in three selected crosses, involving four parents, including their F 1′s, F 2′s and first back crosses generations. The six generations of these crosses were evaluated during summer, Rabi 2012 for days to first flowering, days to first picking, plant height (cm), number of branches per plant, fruit length (cm), fruit diameter (mm), number of seed per fruit, number of fruits per plant (green), green fruit yield per plant (g), number of fruits per plant (dry), dry fruit yield per plant (g), days to last picking and capsaicin content (%). The data generated was subjected to test epistasis and six generation mean analysis. It was found that, all the types of gene action i.e. additive, dominance and interaction components were found to be play a major role in their inheritance. The importance of additive, dominant and epistatic interactions suggested the use of recurrent selection, reciprocal recurrent selection, diallel selective mating scheme or bi-parental mating system for improvement of these traits, while the heterosis breeding is recommended for the crosses where complimentary epistasis was observed. Taking in to account the complex behavior of genes in these traits, modified bulk selection is recommended for varietal improvement of chilli in these crosses, in which the selection is performed after attaining the homozygosity.