Miracle-dz/UniFAR-FTUs huggingface dataset:
On the nonexistence of purely Stepanov almost-periodic solutions of ordinary differential equations

It is shown that in uniformly convex Banach spaces, Stepanov almost-periodic functions with Stepanov almost-periodic derivatives are uniformly almost-periodic in the sense of Bohr. This in natural situations yields, jointly with the derived properties of the associated Nemytskii operators, the nonexistence of purely (i.e.nonuniformly continuous) Stepanov almost-periodic solutions of ordinary differential equations. In particular, the existence problem of such solutions, considered in a series of five papers of Z. Hu and A. B. Mingarelli, is answered in a negative way.
Chronic neutrophilic leukemia associated with thrombocytosis and a CSF3R Q781* nonsense mutation

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm characterized by sustained mature neutrophilia, bone marrow granulocytic hyperplasia, and hepatosplenomegaly, in the setting of negativity for BCR/ABL translocation. Approximately 200 cases of CNL had been reported, although the exact number of true cases remains unknown. 1 According to the World Health Organization (WHO) and the international consensus classification (ICC) of myeloid neoplasms and acute leukemias the diagnosis of CNL requires exclusion of reactive neutrophilia, dysplasia or other chronic myeloid neoplasms, and the presence of activating CSF3R mutations together with mature neutrophilia (leukocytosis ≥ 13 (cid:1) 10 9 /L with ≥ 80% neutrophils, < 10% circu-lating neutrophil precursors, < 10% monocytes and <1% blasts in the peripheral blood; and <5% blast in the bone marrow, which is typically hypercellular), and the average age of presentation is in the mid-60s.
First results from Goddard High-Resolution Spectrograph - C I, S I, and CO toward Xi Persei and the physical conditions in diffuse clouds

Observations made by the Goddard High Resolution Spectrograph of the cool, neutral interstellar gas in the line of sight to Xi Per are reported. Heliocentric velocities and equivalent widths were measured for absorption lines of C I and S I. Synthetic spectra were computed and fitted to the observed CO(2-0) and (3-0) bands in the A IPi - X 1Sigma(+) system. Derived populations of the C I ground-state fine-structure levels and the CO ground-state rotational levels were used to derive densities of two of the three, and possibly four, detected cloud components. The velocity component displaying the strongest C I absorption reveals extraordinarily high pressure.
Sexual Recidivism During Treatment: Impact on Therapists

There are few studies of therapists’ reactions to working with individuals who have committed sexual offenses, and almost none on reactions following sexual recidivism by a patient who is currently in treatment. Consequently, the aim of the current study was to analyze the cognitive and emotional reactions, as well as the intervention strategies, of therapists who have learned of the sexual recidivism of a patient. A total of 59 participants from the province of Quebec (Canada) completed a questionnaire on their reactions to this event. Participants’ responses to their patient’s recidivism varied as a function of gender, experience, and the way they learned of the recidivism. The most common cognitions reported were thinking of the victim and thinking about the consequences of further judicialization for the patient and those close to them. The most common emotions reported were sadness for the victim and fear that the patient would reoffend again. The most common intervention strategies were being sensitive to the experience of the patient and asking the patient what drove them to offend. Support measures for therapists working with individuals who have committed sexual offenses during treatment are discussed.
Acquired Hemophilia A: A Retrospective Multicenter Analysis of 42 Patients

Introduction Immunosuppressive therapy (IST) for acquired hemophilia A (AHA) results in remission within days to months in 60% to 80% of patients. However, little is known regarding the predictors of response. Aim This study aimed to identify the factors that influence response to treatment. Methods The data of 42 patients with AHA from three hospitals were retrospectively analyzed. Results All 42 AHA patients received IST; complete treatment data were available for 34 patients. The response rate was 60% among the 5/34 (14.7%) patients who received steroids alone, 70.8% among the 24/34 (70.6%) patients who received steroids plus cyclophosphamide, and 80% among the 5/34 (14.7%) patients who received steroids plus cyclophosphamide and rituximab. Overall, 29/34 (85.3%) patients achieved CR; 4/34 (13.8%) of them relapsed after a median time of 410 (21–1279) days. Adverse events occurred in 14/34 (41.2%) patients: 13/34 (38.2%) had infections and 1/34 (2.9%) developed pancytopenia. In univariate and multivariate Cox regression analyses, FVIII inhibitor titer ≥20 BU/mL was the only significant prognostic factor affecting time to CR. No variable had significant effect on OS. Conclusion FVIII inhibitory antibody titer ≥20 BU/mL appears to be an important predictor of time to complete response in patients with acquired hemophilia A treated with immunosuppressive therapy.
Knowledge sharing behaviour among head nurses in online health communities: The moderating role of knowledge self-efficacy

Background Head nurses are vital in understanding and encouraging knowledge sharing among their followers. However, few empirical studies have highlighted their contribution to knowledge-sharing behaviour in Online Health Communities (OHCs). In addition, scant literature has examined the moderating role of knowledge self-efficacy in this regard. Purposes This study examines the moderating role of self-efficacy between the association of four selected individual factors of head nurses (i.e., Trust, Reciprocity, Reputation, and Ability to Share) and their knowledge-sharing behaviour in OHCs in Jordan. Method The data were obtained by using a self-reported survey from 283 head nurses in 22 private hospitals in Jordan. A moderation regression analysis using a structural equation modelling approach (i.e. Smart PLS-SEM, Version 3) was utilised to evaluate the study’s measurement and structural model. Results Knowledge self-efficacy moderates the relationship between the three individual factors (i.e., Trust, Reciprocity, and Reputation) and knowledge-sharing behaviours. However, self-efficacy did not moderate the relationship between the ability to share and knowledge-sharing behaviours. Implications This study contributes to understanding the moderating role of knowledge self-efficacy among head nurses in online healthcare communities. Moreover, this study provides guidelines for head nurses to become active members in knowledge sharing in OHCs. The findings of this study offer a basis for further research on knowledge sharing in the healthcare sector.
The impact of right atrial pressure on outcomes in patients undergoing TIPS, an ALTA group study

Background and Aims: Single-center studies in patients undergoing TIPS suggest that elevated right atrial pressure (RAP) may influence survival. We assessed the impact of pre-TIPS RAP on outcomes using the Advancing Liver Therapeutic Approaches (ALTA) database. Approach and Results: Total 883 patients in ALTA multicenter TIPS database from 2010 to 2015 from 9 centers with measured pre-TIPS RAP were included. Primary outcome was mortality. Secondary outcomes were 48-hour post-TIPS complications, post-TIPS portal hypertension complications, and post-TIPS inpatient admission for heart failure. Adjusted Cox Proportional hazards and competing risk model with liver transplant as a competing risk were used to assess RAP association with mortality. Restricted cubic splines were used to model nonlinear relationship. Logistic regression was used to assess RAP association with secondary outcomes. Pre-TIPS RAP was independently associated with overall mortality (subdistribution HR: 1.04 per mm Hg, 95% CI, 1.01, 1.08, p=0.009) and composite 48-hour complications. RAP was a predictor of TIPS dysfunction with increased odds of post-90-day paracentesis in outpatient TIPS, hospital admissions for renal dysfunction, and heart failure. Pre-TIPS RAP was positively associated with model for end-stage liver disease, body mass index, Native American and Black race, and lower platelets. Conclusions: Pre-TIPS RAP is an independent risk factor for overall mortality after TIPS insertion. Higher pre-TIPS RAP increased the odds of early complications and overall portal hypertensive complications as potential mechanisms for the mortality impact.
Recombination activity of contaminated dislocations in silicon: A model describing electron-beam-induced current contrast behavior

Existing experimental data give many evidences that the recombination rate of minority charge carriers at dislocations in silicon depends strongly on dislocation decoration by transition metal impurities. Here, we present a model that allows a quantitative description of the recombination of minority carriers at decorated dislocations. It assumes that shallow dislocation bands, induced by the strain field, and deep electronic levels, caused by impurity atoms, which have segregated at the dislocation, or by core defects, can exchange electrons and holes. As a consequence, the recombination of carriers captured at dislocation bands can be drastically enhanced by the presence of even small concentrations of impurity atoms at the dislocation core. The model allows us not only to explain experimentally observed dependences of the recombination rate on temperature and excitation level, but also to estimate the concentration of deep level impurities at dislocations.
Cardiac and Gastric Interoceptive Awareness Have Distinct Neural Substrates

Abstract Interoceptive awareness, an awareness of the internal body state, guides adaptive behavior by providing ongoing information on body signals, such as heart rate and energy status. However, it is still unclear how interoceptive awareness of different body organs are represented in the human brain. Hence, we directly compared the neural activations accompanying attention to cardiac (related to heartbeat) and gastric (related to stomach) sensations, which generate cardiac and gastric interoceptive awareness, in the same population (healthy humans, N = 31). Participants were asked to direct their attention toward heart and stomach sensations and become aware of them in a magnetic resonance imaging (MRI) scanner. The results indicated that the neural activations underlying gastric attention encompassed larger brain regions, including the occipitotemporal visual cortices, bilateral primary motor cortices, primary somatosensory cortex, left orbitofrontal cortex, and hippocampal regions. Cardiac attention, however, selectively activated the right anterior insula extending to the frontal operculum compared with gastric attention. Moreover, our detailed analyses focusing on the insula, the most relevant region for interoceptive awareness, revealed that the left dorsal middle insula encoded cardiac and gastric attention via different activation patterns, but the posterior insula did not. Our results demonstrate that cardiac and gastric attention evoke different brain activation patterns; in particular, the selective activation may reflect differences in the functional roles of cardiac and gastric interoceptive awareness.
Acute stress alters probabilistic reversal learning in healthy male adults

Behavioural adaptation is a fundamental cognitive ability, ensuring survival by allowing for flexible adjustment to changing environments. In laboratory settings, behavioural adaptation can be measured with reversal learning paradigms requiring agents to adjust reward learning to stimulus–action–outcome contingency changes. Stress is found to alter flexibility of reward learning, but effect directionality is mixed across studies. Here, we used model‐based functional MRI (fMRI) in a within‐subjects design to investigate the effect of acute psychosocial stress on flexible behavioural adaptation. Healthy male volunteers (n = 28) did a reversal learning task during fMRI in two sessions, once after the Trier Social Stress Test (TSST), a validated psychosocial stress induction method, and once after a control condition. Stress effects on choice behaviour were investigated using multilevel generalized linear models and computational models describing different learning processes that potentially generated the data. Computational models were fitted using a hierarchical Bayesian approach, and model‐derived reward prediction errors (RPE) were used as fMRI regressors. We found that acute psychosocial stress slightly increased correct response rates. Model comparison revealed that double‐update learning with altered choice temperature under stress best explained the observed behaviour. In the brain, model‐derived RPEs were correlated with BOLD signals in striatum and ventromedial prefrontal cortex (vmPFC). Striatal RPE signals for win trials were stronger during stress compared with the control condition. Our study suggests that acute psychosocial stress could enhance reversal learning and RPE brain responses in healthy male participants and provides a starting point to explore these effects further in a more diverse population.
Effects of Vitamin D Supplementation on Testosterone, Prostate, and Lower Urinary Tract Symptoms: A Prospective, Comparative Study

Purpose Several studies have associated the serum vitamin D level with total testosterone levels and the prostate volume. Herein, we investigated the effect of vitamin D supplementation on testosterone, prostate, and lower urinary tract symptoms (LUTS) in men. Materials and Methods Men over 40 years of age diagnosed with a vitamin D deficiency (25[OH]D <20 ng/mL) who received vitamin D supplementation for one year were included in the study and administered 25,000 IU of cholecalciferol every 2 weeks. Prostate ultrasound, uroflowmetry, postvoid residual urine volume measurement, and serological tests (serum testosterone levels, etc.) were performed upon diagnosis and one year later. Participants also answered the International Prostate Symptom Score (IPSS) and Aging Males’ Symptoms Scale (AMS) questionnaires. Results A significant increase was observed in the vitamin D level following one year of vitamin D supplementation, with a significant decrease in the postvoid residual urine volume, total IPSS score and without a significant change in the prostate volume. Improved psychological subscale score of AMS questionnaire was observed with a statistical significance. Conclusions Vitamin D supplementation suppressed the increase in the prostate volume and improved the LUTS. Although there is no direct effect on serum testosterone levels, vitamin D supplementation helped improve hypogonadal symptoms.
Medical Management of Canine Chronic Ulcerative Stomatitis Using Cyclosporine and Metronidazole

Canine chronic ulcerative stomatitis (CCUS) is a spontaneously occurring, painful, and often debilitating condition of the oral cavity, with a suspected immune-mediated component. The response to pharmacological treatment is generally poor, thus the need to identify more effective medical therapies for this condition. This article describes a prospective clinical trial that was designed to evaluate the efficiency of a combination of cyclosporine and metronidazole in managing CCUS. The hypothesis was that a combination of cyclosporine and metronidazole would effectively minimize clinical signs associated with CCUS. Ten client-owned dogs with a biopsy-confirmed diagnosis consistent with CCUS were prescribed cyclosporine (5 mg/kg) for 1 week, followed by the addition of metronidazole (15-20 mg/kg), both administered orally once daily. The cyclosporine dosage interval was lengthened over time. Dogs were observed for a 6-month period and evaluated using a 32-point Canine Ulcerative Stomatitis Disease Activity Index (CUSDAI). Regular cyclosporine therapeutic drug monitoring was also conducted by the measurement of whole blood cyclosporine levels and the pharmacodynamic assessment of the T-cell expression of IL-2. The results demonstrated that a combination of cyclosporine and metronidazole was effective in minimizing the clinical signs of CCUS and in reducing CUSDAI scores. Neither blood cyclosporine levels nor the T-cell expression of IL-2 predicted improvement in clinical signs and CUSDAI scores, although there was a correlation between blood drug concentrations and the suppression of T-cell IL-2 expression. The evaluation of clinical signs and CUSDAI scores appears to be the most effective means of assessing response to therapy, and therapeutic drug level monitoring does not appear to be routinely indicated.
Jumping into the future: overcoming pharmacokinetic/pharmacodynamic hurdles to optimize the treatment of severe difficult to treat-Gram-negative infections with novel beta-lactams

ABSTRACT Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR) Gram-negative infections currently represents an unmet clinical need. Areas covered This review provides a critical reappraisal of real-world evidence supporting the role of pharmacokinetic/pharmacodynamic (PK/PD) optimization of novel beta-lactams in the management of DTR Gram-negative infections. The aim was to focus on prolonged and/or continuous infusion administration, penetration rates into deep-seated infections, and maximization of PK/PD targets in special renal patient populations. Retrieved findings were applied to the three most critical clinical scenarios of Gram-negative resistance phenotypes (i.e. carbapenem-resistant Enterobacterales; difficult-to-treat resistant Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter baumannii). Expert opinion Several studies supported the role of PK/PD optimization of beta-lactams in the management of DTR Gram-negative infections for both maximizing clinical efficacy and preventing resistance emergence. Optimizing antimicrobial therapy with novel beta-lactams based on the so called ‘antimicrobial therapy puzzle’ PK/PD concepts may represent a definitive jump into the future toward a personalized patient management of DTR Gram negative infections. Establishing a dedicated and coordinated multidisciplinary team and implementing a real-time TDM-guided personalized antimicrobial exposure optimization of novel beta-lactams based on expert clinical pharmacological interpretation, could represent crucial cornerstones for the proper management of DTR Gram-negative infections.
Ultrafast photo-induced reaction dynamics in bacteriorhodopsin and its Trp mutants

This review paper presents the recent advances made in observing and understanding the ultrafast photo-reaction dynamics in retinal proteins, in particular bacteriorhodopsin (bR), with a special emphasis on the retinal–protein interactions and the mechanisms of protein activation on a sub-picosecond timescale. We review our latest results obtained on wild-type (wt) bR, and on two tryptophan mutants W86F and W182F, obtained by femtosecond pump–probe experiments. It was shown that light-induced charge translocations and modifications of the protein electrostatics can be monitored by the near-UV differential absorption of Trp86, which experiences a linear intra-protein Stark effect. In the same spectral region, non-exponential wavepacket-like dynamics was found for the formation of the 13-cis retinal isomer in wt-bR. The present paper highlights how this finding is underpinned by the experiments on the mutants. New results are presented regarding the reaction dynamics in the Trp mutants, studied in the vis/near-IR by transient absorption. Interestingly, W86F displays a faster excited state decay and photoproduct formation than wt-bR. This is tentatively attributed to an all-trans/13-cis ground state mixture known to occur in the light-adapted state in this special mutant, due to increased conformational flexibility of the retinal chromophore.
More on Early ENSOs: Evidence from Australian Documentary Sources

Abstract Early documentary records of the British colony of New South Wales, Australia, have been examined for evidence of droughts. The years of occurrence of these early droughts were compared with the chronologies of El Niñ:o-Southern Oscillation (ENSO) events, as determined by Hamilton and Garcia (1986) and Quinn et al. (1978) from documentary evidence of northern Peruvian rainfall. Most droughts were associated with ENSO events, and vice versa, confirming the relationship found in many studies using more-recent instrumental data. The study demonstrates the stability, over a long period, of the correlation between Australian droughts and ENSOs.
Benefits of collaborative remembering in older and younger couples: the role of conversation dynamics and gender

ABSTRACT We experimentally explored whether and how conversation dynamics would benefit collaborative remembering in intimate couples over time. To this end, we ran a study with a three-factor mixed design with relationship type (couples vs. strangers) and age (older adults vs. younger adults) as between-participants variables, and remembering condition (collaborative vs. individual) as a within-participants variable. Thirty pairs of intimate couples (fifteen long-term relationship older couples, fifteen short-term relationship younger couples) and thirty pairs of corresponding stranger-pairs (including older strangers and younger strangers) were compared with respect to recall accuracy and conversation dynamics, specifically considering the role of gender. Results revealed significant collaborative facilitation only in older couples. Also, females’ communication behaviours facilitated males’ collaborative remembering performance only in older (vs. younger) couples. In addition, a gender-specific pattern of shifts from the individual to collaborative context emerged only in older couple (vs. strangers). The findings are consistent with the notion that a longer experience of collaboration and more effective conversation dynamics allow older (vs. younger) couples to perform better at collaborative remembering. We discuss processes underlying the observed gender differences, and the social and motivational implications of collaborative remembering.