Miracle-dz/UniFAR-FTUs huggingface dataset:
Water-soluble pristine C60 fullerene attenuates acetaminophen-induced liver injury

Introduction: Oxidative stress has been suggested as the main trigger and pathological mechanism of toxic liver injury. Effects of powerful free radical scavenger С60 fullerene on rat liver injury and liver cells (HepG2 line) were aimed to be discovered. Methods: Acute liver injury (ALI) was simulated by single acetaminophen (APAP, 1000 mg/kg) administration, on a chronic CLI, by 4 weekly APAP administrations. Pristine C60 fullerene aqueous colloid solution (C60FAS; initial concentration 0.15 mg/mL) was administered per os or intraperitoneally at a dose of 0.5 mg/kg (ALI) or 0.25 mg/kg (CLI) daily for 2 or 28 days, respectively, after first APAP dose. Animals were sacrificed at 24th hour after the last dose. Biochemical markers of blood serum and liver autopsies were analyzed. EGFR expression in HepG2 cells after 48-hour incubation with C60FAS was assessed. Results: Increase of serum conjugated and unconjugated bilirubin (up to 1.4-3.7 times), ALT (by 31-37%), and AST (by 18%) in non-treated ALI and CLI rats were observed, suggesting the hepatitis (confirmed by histological analysis). Liver morphological state (ALI, CLI), ALT (ALI and CLI), bilirubin (CLI), α-amylase, and creatinine (ALI) were normalized with C60FAS administration in both ways, which may indicate its protective impact on liver. However, unconjugated bilirubin sharply increased in ALI animals receiving C60FAS (up to 12 times compared to control), suggesting the augmentation of bilirubin metabolism. Furthermore, C60FAS inhibited EGFR expression in HepG2 cells in a dose-dependent manner. Conclusion: C60FAS could partially correct acute and chronic toxic liver injury, however, it could not normalize bilirubin metabolism after acute exposure.
Incidence and mortality rates of colorectal cancer in Malaysia

OBJECTIVES This is the first study that estimates the incidence and mortality rate for colorectal cancer (CRC) patients in Malaysia by sex and ethnicity. METHODS The 4,501 patients were selected from National Cancer Patient Registry-Colorectal Cancer data. Patient survival status was cross-checked with the National Registration Department. The age-standardised rate (ASR) was calculated as the proportion of CRC cases (incidence) and deaths (mortality) from 2008 to 2013, weighted by the age structure of the population, as determined by the Department of Statistics Malaysia and the World Health Organization world standard population distribution. RESULTS The overall incidence rate for CRC was 21.32 cases per 100,000. Those of Chinese ethnicity had the highest CRC incidence (27.35), followed by the Malay (18.95), and Indian (17.55) ethnicities. The ASR incidence rate of CRC was 1.33 times higher among males than females (24.16 and 18.14 per 100,000, respectively). The 2011 (44.7%) CRC deaths were recorded. The overall ASR of mortality was 9.79 cases, with 11.85 among the Chinese, followed by 9.56 among the Malays and 7.08 among the Indians. The ASR of mortality was 1.42 times higher among males (11.46) than females (8.05). CONCLUSIONS CRC incidence and mortality is higher in males than females. Individuals of Chinese ethnicity have the highest incidence of CRC, followed by the Malay and Indian ethnicities. The same trends were observed for the age-standardised mortality rate.
Genotyping-by-Sequencing of Gossypium hirsutum Races and Cultivars Uncovers Novel Patterns of Genetic Relationships and Domestication Footprints

Determining the genetic rearrangement and domestication footprints in Gossypium hirsutum cultivars and primitive race genotypes are essential for effective gene conservation efforts and the development of advanced breeding molecular markers for marker-assisted breeding. In this study, 94 accessions representing the 7 primitive races of G hirsutum, along with 9 G hirsutum and 12 Gossypium barbadense cultivated accessions were evaluated. The genotyping-by-sequencing (GBS) approach was employed and 146 558 single nucleotide polymorphisms (SNP) were generated. Distinct SNP signatures were identified through the combination of selection scans and association analyses. Phylogenetic analyses were also conducted, and we concluded that the Latifolium, Richmondi, and Marie-Galante race accessions were more genetically related to the G hirsutum cultivars and tend to cluster together. Fifty-four outlier SNP loci were identified by selection-scan analysis, and 3 SNPs were located in genes related to the processes of plant responding to stress conditions and confirmed through further genome-wide signals of marker-phenotype association analysis, which indicate a clear selection signature for such trait. These results identified useful candidate gene locus for cotton breeding programs.
Making nursing homes more community-oriented: insights from an exploratory study in Germany

ABSTRACT Nursing homes have been criticised for restricting the lifestyle of older people in need of care. As concepts of elder care have changed and services in formal care have developed further, efforts towards deinstitutionalisation have led to the enhancement of community care models. This paper discusses how ideas of community care can also influence reform within institutional care. The study focuses on the challenges and obstacles of practice change arising in German nursing homes by opening up to civil society principles. Applying the model of organisational hybridisation, the concept of 12 German nursing homes regarding family and community partners' involvement were analysed through explorative qualitative interviews with nursing home directors. The nursing homes have conceived various forms of co-operation with community actors. Nevertheless, emerging tensions between state, market and civil society conceptions of the nursing homes limit practical change. The ‘organisational hybridisation’ has generated two general problems to be discussed here: first, the difficulty nursing homes have in opening their doors to new perceptions of care as well as to the interests of their community partners. Second, the fact that the nursing homes tend either to strive for an integration in community life or for the maintenance of a ‘sheltered zone’ for their residents implies that nursing homes' definition of ‘normality’ has a strong influence on their chosen concept of care.
Selección para rendimiento y calidad de fruto de cruzas planta X planta entre variedades de tomate de cáscara

1 Programa en Genetica, Instituto de Recursos Geneticos y Productividad, Colegio de Postgraduados. Km. 36.5 Carr. Mexico-Texcoco. C.P. 56230 Montecillo, Edo. de Mexico. Direccion Actual: Centro Regional Universitario de Occidente, Universidad Autonoma Chapingo. Manuel M. Dieguez No. 113. Sector Hidalgo, Colonia Moderna, C.P. 44680 Guadalajara, Jalisco. Tel y Fax: 01 (33)3615-1729. Correo electronico: hersan03@hotmail.com. Departamento de Fitotecnia, Universidad Autonoma Chapingo. Km. 38.5 Carr. Mexico-Texcoco. C.P. 56230 Chapingo, Edo de Mexico. Tel y Fax: 01 (595) 952-1642. * Autor responsable
Violence Toward Judicial Officials

This article explores several unique aspects that distinguish judicial officials from other public figures targeted for violence. Assaults and threats against judicial officials derive from the officials' role in the judicial system. They tend to have multiple victims, be motivated out of anger or disappointment over a particular court case, and--because of the court case--involve an interpersonal relationship between target and assailant. The article also argues for the necessity of researching both attackers and nonattackers in order to compare the similarities and differences between them, for example, the method by which attackers and nonattackers choose to communicate with or contact their targets. The article concludes with a call for more research on local judicial jurisdictions. This promises the largest laboratory for understanding violence toward judicial officials.
Evaluation of efficacy, expulsion and safety of post-placental and intra-cesarean insertion of intrauterine contraceptive devices -

Background: The objective of the study was to evaluate the safety and efficacy of immediate postpartum intrauterine contraceptive device (PPIUCD) insertion in women delivering vaginally or by cesarean section. Methods: This prospective study was carried out at General Hospital [Tertiary care] from August 2014 to September 2015. All antenatal patients admitted for delivery to our hospital were counseled for PPIUCD. Also consent was taken from those who opted for PPIUCD insertion. Results: A total of 2016 women were counseled for PPIUCD adoption. Out of this, 1312 women accepted this method. Total number of deliveries during the study period was 2835. Total acceptance rate was 46.27%. The expulsion rate was 10.63% while removal rate was 7.74%. Out of 555 women who came for follow up, 453 women continued PPIUCD. Thus, continuation rate was 81.62%. Conclusions: PPIUCD is easily accessible, reversible and cost effective contraceptive method for most postpartum women specially lactating women.
The G gamma:A gamma composition of fetal hemoglobin in fetuses and newborns

To determine whether the G gamma:A gamma HbF switch is coordinated in development with the HbF:HbA switch, hemoglobin F Gly/Ala (G gamma:A gamma) heterogeneity was evaluated by electrophoresis on polyacrylamide gels. The mean G gamma was 70% in 19 newborns, similar to the published value of 73% obtained by amino acid analysis of the gamma CG-3 peptide. In 29 fetuses at 18–20-wk gestation, G gamma was 71%. The values were similar in normal fetuses and newborns and in those with hemoglobinopathies. The synthetic ratio of 3H-leucine-labeled G gamma:A gamma was identical to the ratio found in the globin protein accumulated by 20 wk. The proportion of G gamma was also identical in 6 paired samples, at 20-wk gestation and at birth. Thus, G gamma production does not decline with respect to A gamma in utero at the time of onset of the HbF:HbA switch.
The role of sex-based developmental class in predicting group reproductive output in wild callitrichids

Prior research on cooperative breeders has considered correlations between group reproductive output (GRO) and the number of individuals in each age-sex class, but without controlling for uneven sampling efforts, the underlying effects of group size, and pseudoreplication at the group and species levels. Among callitrichids, age-sex classes do not provide meaningful categories, as individuals within an age-sex class can demonstrate varying reproductive development due to reproductive dominance of a few individuals per group. This study re-assesses the drivers of GRO in callitrichids by a) conducting a meta-analysis of published studies of callitrichid group composition; b) determining a novel method to assign developmental class based on reproductive morphology; and c) utilizing a multistep modelling approach to assess whether any sex-based developmental class predicts both the presence and the numbers of surviving offspring among free-ranging saddleback (Leontocebus weddelli) and emperor tamarins (Saguinus imperator) in Peru. The meta-analysis utilizing a historical dataset revealed that adult females and group size, but not the number of adult males is significantly correlated with GRO. Statistical models of the new dataset revealed that only mature males predicted if groups had any infants at all, but that the number of surviving infants was predicted by mature females and group size. Thus mature males appear to be necessary for groups to raise any infants, but mature females and a larger group size increase group reproductive output overall.
Pleural tuberculosis in patients infected with HIV in Addis Ababa.

A prospective study conducted at a tertiary care referral hospital (Black Lion Hospital) in Addis Ababa Ethiopia during 1990-91 compared the clinical features and outcomes of 90 adult patients with pleural tuberculosis and 120 surgical patients admitted for non-HIV-related conditions. 22% of tuberculosis patients compared with 6.7% of surgical controls were HIV-positive. The average age of seropositive patients was 29 years. 11 of the HIV-infected tuberculosis patients met the clinical case definition for AIDS. The most common extrapulmonary manifestation was lymphadenopathy. In 9 (45%) of the 20 HIV-positive tuberculosis patients compared with 9 (12.9%) of the 70 seronegative tuberculosis patients the tuberculosis had disseminated to several other sites including the lymph nodes liver and spleen and peritoneum. Among patients with pleural tuberculosis HIV-positive patients were also significantly more likely than their HIV-negative counterparts to have a longer duration of illness prior to hospitalization bilateral pleural effusion adverse reaction to anti-tuberculosis drugs and increased mortality. Hepatitis was the most common treatment-related side effect. The finding of bilateral pleural effusion is suggested as an indicator of the presence of underlying HIV infection in tuberculosis patients.
Responding to depression-related Imgur posts: A content analysis of social support and non-bona fide features in user-generated comments

Objectives A growing body of health communication scholarship has explored the utility of social media platforms for eliciting social support, although much of this scholarship has focused on Facebook and Twitter. This study contributes to this body of research by identifying support in comments submitted to depression-related Imgur posts. Furthermore, the use of non-bona fide linguistic features (e.g. humor, sarcasm, and irony) is documented for comparison with supportive elements. Methods A content analysis was performed of 1530 comments submitted in response to 20 popular Imgur posts about depression, including the emergence of four social support types outlined by the Multi-Dimensional Support Scale—reassuring, empathic, informational, and tangible support—as well as non-bona fide features. Results Findings suggest a supportive discourse, with nearly 60% of comments containing some supportive element. Reassuring and informational support emerged most prominently (26.3% and 26.2% of comments, respectively), followed by empathic (22.9%) and tangible (0.3%) support types. Non-bona fide features manifested in 28.8% of comments. Results indicate significant covariation between non-bona fide features and support, as these infrequently co-occurred. Conclusions This study’s findings suggest that depression-related messages frequently receive support from Imgur commenters, especially reassuring and informational support. Additionally, this study provides a conceptual framework for future analyses of online social support by integrating non-bona fide communication with established support types. The results of this study could have implications for health professionals and scholars interested in the use of social media platforms such as Imgur, which serves a predominantly young male demographic, for support provision.
Association of MS4A6A, CD33, and TREM2 gene polymorphisms with the late-onset Alzheimer’s disease

Introduction: Alzheimer’s disease (AD), which is a progressive neurodegenerative disorder, causes structural and functional brain disruption. MS4A6A, TREM2, and CD33 gene polymorphisms loci have been found to be associated with the pathobiology of late-onset AD (LOAD). In the present study, we tested the hypothesis of association of LOAD with rs983392, rs75932628, and rs3865444 polymorphisms in MS4A6A, TREM2, CD33 genes, respectively. Methods: In the present study, 113 LOAD patients and 100 healthy unrelated age- and gender-matched controls were selected. DNA was extracted from blood samples by the salting-out method and the genotyping was performed by RFLP-PCR. Electrophoresis was carried out on agarose gel. Sequencing was thereafter utilized for the confirmation of the results. Results: Only CD33 rs3865444 polymorphism revealed a significant difference in the genotypic frequencies of GG (P = 0.001) and GT (P = 0.001), and allelic frequencies of G (P = 0.033) and T (P = 0.03) between LOAD patients and controls. Conclusion: The evidence from the present study suggests that T allele of CD33 rs3865444 polymorphism is associated with LOAD in the studied Iranian population.
Management of Repeat Breeding Under Field Condition Using Ovsynch Protocol in Cross Bred Cows

A study was carried out on 20 repeat breeding crossbred cows to evaluate the use of ovsynch protocol (Hormonal Protocol) in improving the reproductive efficiency. All the repeat breeding cows were treated with 0.02mg GnRH (Receptal 5 ml i/m) on the day of estrus, on 7th day of estrus cows were given PGF2a (Lutalyse 5 ml I/m) and on 9th day of estrus, all repeat breeding cows were given repeat dose of 0.02mg GnRH (Receptal 5 ml i/m). Artificial insemination was carried out on 24 hrs after last GnRH injection. Conception rate in first, second, third service and overall conception rate was 30.0, 20.5, 5.0 and 55.0 per cent, respectively. Hence, ovsynch protocol is recommended for their judicious use in the field to solve the problem of repeat breeding cross bred cows.
Initial Fluid Resuscitation Following Adjusted Body Weight Dosing in Sepsis and Septic Shock

Abstract Introduction Fluid administration is considered a fundamental part of early sepsis treatment. Despite abundant research, fundamental questions about the amount of fluids to be given remain unanswered. Recently, the idea of adjusting the fluid load to the ideal body weight emerged, as obesity rates are increasing, and fluid overload was proven to increase mortality. Aim of the study The study aimed to determine whether advanced haemodynamic monitoring supports the adjustment of the initial fluid load to the ideal body weight (IBW). Methods Seventy-one patients with sepsis and septic shock were enrolled in the study. The initial fluid resuscitation was performed using local protocols. The haemodynamic status was assessed after the initial fluid load by transpulmonary thermos-dilution technique and the renal outcome recorded at twenty-four hours. Results 68.6% of the patients included in the study had weight disorders ranging from BMI+20% to morbid obesity. Before IBW adjustment, only 49.3% received the 30 ml/kg fluid load recommended by Surviving Sepsis Campaign Guidelines (2016) (SSC). After IBW adjustment, 70.4% received the recommended fluid dose. The difference in fluid load/kg before and after the bodyweight adjustment was statistically significant (p<0.01). After the initial fluid load, the majority of the macro haemodynamic parameters were in the targeted range. There was no statistically significant difference between the urinary output outcome at 24 hours or the 28 days mortality rates between the patients resuscitated by the SSC and those who received less fluid. Conclusions Advanced haemodynamic monitoring was in favour of adjusting the initial fluid load to the IBW. There were no statistically significant differences either in the urinary output outcome at twenty-four hours, or in the twenty-eight-day mortality rates between the patients who received the 30 ml/kg IBW and those who received less than 30 ml/kg IBW.
Efficacy of Spinosad as Seed Protectant against the Pests of Stored Maize

A laboratory study was undertaken to test the efficacy of spinosad against the pests of stored maize. Spinosad as seed protectant was most effective at 0.5, 1.0 and 2.0 mg ai kg−1 seed against Sitophilus oryzae, Rhyzopertha dominica and Corcyra aephalonica. Spinosad persisted on maize zeeds for fouo months ana caused more than 95% mortality of S. oryzae with no progeny production and damage to the seeds. After four months its efficacy started declining and produced few progenies with 5% damage to the stored seed. In the case of R. dominica and C. cephalonica, it caused complete mortality at all the doses tested for rour months without any damage to the seeds.
Comparative Analysis of Decentralized Real Time Anomaly Detection Mechanisms for IoT

Anomaly detection is a major requirement of the current Internet of Things (IoT) and inter-networked communication environment. This research work analyzes recent and prominent contributions in the domain of Anomaly detection. This research is performed especially in domains related to real time operations and IoT environment. The review is performed and results from most prominent models as well as the three models developed during my research are considered for the final analysis. This research concentrates on the working mechanisms and solutions for the major issues in Anomaly detection such as data imbalance, concept drift, centralized mechanisms and noise particularly in IoT domain. The methods used to handle the above issues and its advantages are thoroughly analyzed in this paper.
The discriminative power of the ReproQ: a client experience questionnaire in maternity care

Background The aim of the ReproQuestionnaire (ReproQ) is to measure the client’s experience with maternity care, following WHO’s responsiveness model. To support quality improvement, ReproQ should be able to discriminate best from worst organisational units. Methods We sent questionnaires to 27,487 third-trimester pregnant women (response 31%) and to 37,230 women 6 weeks after childbirth (response 39%). For analysis we first summarized the ReproQ domain scores into three summary scores: total score (all eight domains), personal score (four personal domains), and setting score (four setting domains). Second, we estimated the proportion of variance across perinatal units attributable to the ‘actual’ difference across perinatal units using intraclass correlation coefficients (ICCs). Third, we assessed the ability of ReproQ to discriminate between perinatal units based on both a statistical approach using multilevel regression analyses, and a relevance approach based on the minimally important difference (MID). Finally, we compared the domain scores of the best and underperforming units. Results ICCs ranged between 0.004 and 0.025 for the summary scores, and between 0.002 and 0.125 for the individual domains. ReproQ was able to identify the best and worst performing units with both the statistical and relevance approach. The statistical approach was able to identify four underperforming units during childbirth (total score), while the relevance approach identified 10 underperforming units. Conclusions ReproQ, a valid and efficient measure of client experiences in maternity care, has the ability to discriminate well across perinatal units, and is suitable for benchmarking under routine conditions.