Miracle-dz/UniFAR-FTUs huggingface dataset:
Whole-Brain Propagation Delays in Multiple Sclerosis, a Combined Tractography-Magnetoencephalography Study

Two structurally connected brain regions are more likely to interact, with the lengths of the structural bundles, their widths, myelination, and the topology of the structural connectome influencing the timing of the interactions. We introduce an in vivo approach for measuring functional delays across the whole brain in humans (of either sex) using magneto/electroencephalography (MEG/EEG) and integrating them with the structural bundles. The resulting topochronic map of the functional delays/velocities shows that larger bundles have faster velocities. We estimated the topochronic map in multiple sclerosis patients, who have damaged myelin sheaths, and controls, demonstrating greater delays in patients across the network and that structurally lesioned tracts were slowed down more than unaffected ones. We provide a novel framework for estimating functional transmission delays in vivo at the single-subject and single-tract level. SIGNIFICANCE STATEMENT This article provides a straightforward way to estimate patient-specific delays and conduction velocities in the CNS, at the individual level, in healthy and diseased subjects. To do so, it uses a principled way to merge magnetoencephalography (MEG)/electroencephalography (EEG) and tractography.
Ethical sensitivity and compassion in home care: Leaders’ views

Background With an increasing older population, the pressure on home care resources is growing, which makes it important to ensure the maintenance of quality care. It is known that compassion and ethical sensitivity can improve the quality of care, but little is known about care leaders’ perceptions on ethical sensitivity and compassion in home care and how it is associated with staff competence and thus quality of care. Aim The aim of the study was to explore home care leaders’ perceptions of ethical sensitivity and compassion associated with care quality in home care. Research design, participants, and research context A hermeneutical approach with a qualitative explorative design was used. The data consists of texts from 10 in-depth interviews with home care leaders. Content analysis was used as a method. Ethical considerations The study was conducted following the ethical guidelines of the Declaration of Helsinki and the Finnish Advisory Board of Research Ethics. Research ethics permission was applied for from a Research Ethics Board. Findings One overall theme and four subthemes were found. The overall theme was: “Compassion provides deeper meaning and ethical sensitivity provides means for knowing how to act”. Discussion If nurses fail to be sensitive and compassionate with patients, good and high qualitative home care cannot be achieved. Ethical sensitivity and compassion can be seen as resources in home care but the organization and the care leaders need to provide the support for these to develop. Conclusion This study provides an understanding of the meaning of ethical sensitivity and compassion as sources of strength and their link to quality of care in a home care context. Further studies could focus on how to build compassion and ethical sensitivity into home-based care and how to ensure adequate support for healthcare professionals’ compassion and ethical sensitivity.
Event Segmentation Enhances Older Adults’ Reactive Cognitive Control Bias

ABSTRACT The present study examined the effect of event segmentation on cognitive control mode use in a sample of older adults (N = 30; Mage = 73, SDage = 4.75) using a modified AX-Continuous Performance Test (AX-CPT). This task included a perceptual event boundary between each cue and its forthcoming probe by means of a spatial shift across the left and right side of the display. Past research showed that young adults’ existing proactive control bias could be enhanced in an event segmented AX-CPT relative to their performance on a standard AX-CPT. For older adults who adopt reactive control by default, the event boundary was expected to impede cue-reactivation during probe presentation, and thus further enhance their existing reactive control bias. To examine this, older adults were tested with a standard and an event segmented AX-CPT in two blocks, with error rates revealing a shift toward greater reactive control use in the event segmented relative to the standard AX-CPT. Findings supported our hypothesis that placing a spatial event boundary between each cue and forthcoming probe would further enhance older adults’ reactive control bias. This study contributes to the sparse but growing literature on the effects of task-specific manipulations on cognitive control use. The results are discussed in light of the dual mechanisms of control framework and the event horizon model.
Growth modes of single-walled carbon nanotubes on catalysts

Understanding the growth mechanism of single-walled carbon nanotubes (SWCNTs) and achieving selective growth requires insights into the catalyst structure-function relationship. Using an in situ aberration-corrected environmental transmission electron microscope, we reveal the effects of the state and structure of catalysts on the growth modes of SWCNTs. SWCNTs grown from molten catalysts via a vapor-liquid-solid process generally present similar diameters to those of the catalysts, indicating a size correlation between nanotubes and catalysts. However, SWCNTs grown from solid catalysts via a vapor-solid-solid process always have smaller diameters than the catalysts, namely, an independent relationship between their sizes. The diameter distribution of SWCNTs grown from crystalline Co7W6, which has a unique atomic arrangement, is discrete. In contrast, nanotubes obtained from crystalline Co are randomly dispersed. The different growth modes are linked to the distinct chiral selectivity of SWCNTs grown on intermetallic and monometallic catalysts. These findings will enable rational design of catalysts for chirality-controlled SWCNTs growth.
New models of chaotic inflation in supergravity

We introduce a new class of models of chaotic inflation inspired by the superconformal approach to supergravity. This class of models allows a functional freedom of choice of the inflaton potential V = |f()|2. The simplest model of this type has a quadratic potential m22/2. Another model describes an inflaton field with the standard symmetry breaking potential λ2(2−v2)2. Depending on the value of v and on initial conditions for inflation, the spectral index ns may take any value from 0.97 to 0.93, and the tensor-to-scalar ratio r may span the interval form 0.3 to 0.01. A generalized version of this model has a potential λ2(α−vα)2. At large and α > 0, this model describes chaotic inflation with the power law potential ~ 2α. For α < 0, this potential describes chaotic inflation with a potential which becomes flat in the large field limit. We further generalize these models by introducing a nonminimal coupling of the inflaton field to gravity. The mechanism of moduli stabilization used in these models allows to improve and generalize several previously considered models of chaotic inflation in supergravity.
A-MYB/TCFL5 regulatory architecture ensures the production of pachytene piRNAs in placental mammals

In male mice, the transcription factor A-MYB initiates the transcription of pachytene piRNA genes during meiosis. Here, we report that A-MYB activates the transcription factor Tcfl5 produced in pachytene spermatocytes. Subsequently, A-MYB and TCFL5 reciprocally reinforce their own transcription to establish a positive feedback circuit that triggers pachytene piRNA production. TCFL5 regulates the expression of genes required for piRNA maturation and promotes transcription of evolutionarily young pachytene piRNA genes, whereas A-MYB activates the transcription of older pachytene piRNA genes. Intriguingly, pachytene piRNAs from TCFL5-dependent young loci initiate the production of piRNAs from A-MYB-dependent older loci, ensuring the self-propagation of pachytene piRNAs. A-MYB and TCFL5 act via a set of incoherent feedforward loops that drive regulation of gene expression by pachytene piRNAs during spermatogenesis. This regulatory architecture is conserved in rhesus macaque, suggesting that it was present in the last common ancestor of placental mammals.
Vascular remodeling in sheep implanted with endovascular neural interface

Objective. The aim of this work was to assess vascular remodeling after the placement of an endovascular neural interface (ENI) in the superior sagittal sinus (SSS) of sheep. We also assessed the efficacy of neural recording using an ENI. Approach. The study used histological analysis to assess the composition of the foreign body response. Micro-CT images were analyzed to assess the profiles of the foreign body response and create a model of a blood vessel. Computational fluid dynamic modeling was performed on a reconstructed blood vessel to evaluate the blood flow within the vessel. Recording of brain activity in sheep was used to evaluate efficacy of neural recordings. Main results. Histological analysis showed accumulated extracellular matrix material in and around the implanted ENI. The extracellular matrix contained numerous macrophages, foreign body giant cells, and new vascular channels lined by endothelium. Image analysis of CT slices demonstrated an uneven narrowing of the SSS lumen proportional to the stent material within the blood vessel. However, the foreign body response did not occlude blood flow. The ENI was able to record epileptiform spiking activity with distinct spike morphologies. Significance. This is the first study to show high-resolution tissue profiles, the histological response to an implanted ENI and blood flow dynamic modeling based on blood vessels implanted with an ENI. The results from this study can be used to guide surgical planning and future ENI designs; stent oversizing parameters to blood vessel diameter should be considered to minimize detrimental vascular remodeling.
Does earlier acquisition of motor competence promote pubertal physical activity in Japanese elementary school children: A 4-year follow-up study

ABSTRACT This 4-year follow-up study investigated which profile of motor competence (MC) in early childhood more strongly correlated with moderate-to-vigorous physical activity (MVPA) in early pubescence. A total of 247 first-grade children (152 boys) aged 6 to 7 years old participated in the baseline measurement. MVPA was measured using an accelerometer annually until the fifth grade. Body fat percentage was assessed using dual-energy X-ray absorptiometry at baseline. MC included fundamental movement skills (FMS) and motor performance, which were assessed in terms of locomotor and object control. FMS was assessed by the Test of Gross Motor Development-2, while motor performance (locomotor: run, hop, jump, and side-step, object control: throw, kick, and hand dribble) was assessed by Japanese Physical Fitness and Motor Abilities Test at baseline. Multiple regression analysis showed that locomotor and object control performance were significant predictors of MVPA in later grades in boys but not in girls. These associations between locomotor performance and MVPA mainly remained significant after controlling for body fat and MVPA at baseline. FMS in both genders was not a significant predictor of MVPA in early pubescence. This study suggests that appropriate strategies for increasing MVPA from prepubescence to early pubescence may differ between boys and girls.
Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy

Background Post-traumatic epilepsy (PTE) is a severe complication of traumatic brain injury (TBI). Electroencephalography aids early post-traumatic seizure diagnosis, but its optimal utility for PTE prediction remains unknown. We aim to evaluate the contribution of quantitative electroencephalograms to predict first-year PTE (PTE1). Methods We performed a multicentre, retrospective case–control study of patients with TBI. 63 PTE1 patients were matched with 63 non-PTE1 patients by admission Glasgow Coma Scale score, age and sex. We evaluated the association of quantitative electroencephalography features with PTE1 using logistic regressions and examined their predictive value relative to TBI mechanism and CT abnormalities. Results In the matched cohort (n=126), greater epileptiform burden, suppression burden and beta variability were associated with 4.6 times higher PTE1 risk based on multivariable logistic regression analysis (area under the receiver operating characteristic curve, AUC (95% CI) 0.69 (0.60 to 0.78)). Among 116 (92%) patients with available CT reports, adding quantitative electroencephalography features to a combined mechanism and CT model improved performance (AUC (95% CI), 0.71 (0.61 to 0.80) vs 0.61 (0.51 to 0.72)). Conclusions Epileptiform and spectral characteristics enhance covariates identified on TBI admission and CT abnormalities in PTE1 prediction. Future trials should incorporate quantitative electroencephalography features to validate this enhancement of PTE risk stratification models.
Lyapunov Analysis of Homogeneous Isotropic Turbulence

The present work studies the isotropic and homogeneous turbulence for incompressible fluids through a specific Lyapunov analysis, assuming that the turbulence is due to the bifurcations associated to the velocity field. The analysis consists in the study of the mechanism of the energy cascade from large to small scales through the Lyapunov analysis of the relative motion between two particles and in the calculation of the velocity fluctuation through the Lyapunov analysis of the local deformation and the Navier-Stokes equations. The analysis provides an explanation for the mechanism of the energy cascade, leads to the closure of the von K\'arm\'an-Howarth equation, and describes the statistics of the velocity difference. Several tests and numerical results are presented.
Incidence, mechanism, and protective strategies for 2-year pelvic fixation failure after adult spinal deformity surgery with a minimum six-level fusion.

OBJECTIVE The purpose of this study was to determine the incidence, mechanism, and potential protective strategies for pelvic fixation failure (PFF) within 2 years after adult spinal deformity (ASD) surgery. METHODS Data for ASD patients (age ≥ 18 years, minimum of six instrumented levels) with pelvic fixation (S2-alar-iliac [S2AI] and/or iliac screws) with a minimum 2-year follow-up were consecutively collected (2015-2019). Patients with prior pelvic fixation were excluded. PFF was defined as any revision to pelvic screws, which may include broken rods across the lumbosacral junction requiring revision to pelvic screws, pseudarthrosis across the lumbosacral junction requiring revision to pelvic screws, a broken or loose pelvic screw, or sacral/iliac fracture. Patient information including demographic data and health history (age, sex, BMI, smoking status, American Society of Anesthesiologists score, osteoporosis), operative (total instrumented levels [TIL], three-column osteotomy [3CO], interbody fusion), screw (iliac, S2AI, length, diameter), rod (diameter, kickstand), rod pattern (number crossing lumbopelvic junction, lowest instrumented vertebra [LIV] of accessory rod[s], lateral connectors, dual-headed screws), and pre- and postradiographic (lumbar lordosis, pelvic incidence, pelvic tilt, major Cobb angle, lumbosacral fractional curve, C7 coronal vertical axis [CVA], T1 pelvic angle, C7 sagittal vertical axis) parameters was collected. All rods across the lumbosacral junction were cobalt-chrome. All iliac and S2AI screws were closed-headed tulips. Both univariate and multivariate analyses were performed to determine risk factors for PFF. RESULTS Of 253 patients (mean age 58.9 years, mean TIL 13.6, 3CO 15.8%, L5-S1 interbody 74.7%, mean pelvic screw diameter/length 8.6/87 mm), the 2-year failure rate was 4.3% (n = 11). The mechanisms of failure included broken rods across the lumbosacral junction (n = 4), pseudarthrosis across the lumbosacral junction requiring revision to pelvic screws (n = 3), broken pelvic screw (n = 1), loose pelvic screw (n = 1), sacral/iliac fracture (n = 1), and painful/prominent pelvic screw (n = 1). A higher number of rods crossing the lumbopelvic junction (mean 3.8 no failure vs 2.9 failure, p = 0.009) and accessory rod LIV to S2/ilium (no failure 54.2% vs failure 18.2%, p = 0.003) were protective for failure. Multivariate analysis demonstrated that accessory rod LIV to S2/ilium versus S1 (OR 0.2, p = 0.004) and number of rods crossing the lumbar to pelvis (OR 0.15, p = 0.002) were protective, while worse postoperative CVA (OR 1.5, p = 0.028) was an independent risk factor for failure. CONCLUSIONS The 2-year PFF rate was low relative to what is reported in the literature, despite patients undergoing long fusion constructs for ASD. The number of rods crossing the lumbopelvic junction and accessory rod LIV to S2/ilium relative to S1 alone likely increase construct stiffness. Residual postoperative coronal malalignment should be avoided to reduce PFF.
Spider OPTIMIZATION. II. OPTICAL, MAGNETIC, AND FOREGROUND EFFECTS

Spider is a balloon-borne instrument designed to map the polarization of the cosmic microwave background (CMB) with degree-scale resolution over a large fraction of the sky. Spider's main goal is to measure the amplitude of primordial gravitational waves through their imprint on the polarization of the CMB if the tensor-to-scalar ratio, r, is greater than 0.03. To achieve this goal, instrumental systematic errors must be controlled with unprecedented accuracy. Here, we build on previous work to use simulations of Spider observations to examine the impact of several systematic effects that have been characterized through testing and modeling of various instrument components. In particular, we investigate the impact of the non-ideal spectral response of the half-wave plates, coupling between focal-plane components and Earth's magnetic field, and beam mismatches and asymmetries. We also present a model of diffuse polarized foreground emission based on a three-dimensional model of the Galactic magnetic field and dust, and study the interaction of this foreground emission with our observation strategy and instrumental effects. We find that the expected level of foreground and systematic contamination is sufficiently low for Spider to achieve its science goals.
Obscured star formation at z= 0.84 with HiZELS: the relationship between star formation rate and Hα or ultraviolet dust extinction★

We compare Hα, ultraviolet (UV) and infrared (IR) indicators of star formation rate (SFR) for a well-defined sample of z = 0.84 emission-line galaxies from the High-. z Emission Line Survey (HiZELS). Using emission-line, optical, IR, radio and X-ray diagnostics, we estimate that 5-11 per cent of Hα emitters at this redshift are active galactic nuclei. We detect 35 per cent of the Hα emitters individually at 24 μm, and stack the locations of star-forming emitters on deep 24-μm Spitzer Space Telescope images in order to calculate the typical SFRs of our Hα-emitting galaxies. These are compared to the observed Hα line fluxes in order to estimate the extinction at z = 0.84, and we find a significant increase in dust extinction for galaxies with higher SFRs. We demonstrate that the relationship between SFR and extinction found in the local Universe is also suitable for our high-redshift galaxies, and attribute the overall increase in the typical dust extinction for z = 0.84 galaxies to an increase in the average SFR, rather than to a change in dust properties at higher redshift. We calculate the UV extinction, and find a similar dependence on SFR to the Hα results, but no evidence for a 2175 A UV bump in the dust attenuation law for high-redshift star-forming galaxies. By comparing Hα and UV indicators, we calculate the conversion between the dust attenuation of nebular and stellar radiation, γ, and show that γ = 0.50 ± 0.14. The extinction/SFR relationship is shown to be applicable to galaxies with a range of morphologies and bulge-to-disc ratios, to both merging and non-merging galaxies, and to galaxies within high- and low-density environments, implying that it is a fundamental property of star-forming regions. In order to allow future studies to easily correct for a SFR-dependent amount of dust extinction, we present an equation to predict the extinction of a galaxy, based solely on its observed Hα luminosity, and use this to recalculate the Hα luminosity function and SFR density at z = 0.84.
Fish Consumption and Advisory Awareness among a Representative Sample of Wisconsin Adults, 2017–2019

Purpose To examine fish consumption patterns and fish advisory awareness among Wisconsin adults. Design Cross-sectional data from population-based survey. Setting: 2017-2019 Wisconsin Behavioral Risk Factor Surveillance System (BRFSS), supplemental fish module. Subjects 15,757 Wisconsinites aged ≥18 years. Annual response rates ranged 46.1-53.3%. Measures Fish consumption, advisory awareness, background and demographic characteristics. Analysis Weighted binary and multinomial logistic regression. Results Most Wisconsinites reported eating fish in the past 30 days, with approximately half (49.8%) consuming less than one fish meal per week. One-fifth of adults reported consuming sportfish. Women were less likely to eat any fish (PORadj = .6, 95% CI: .5-.7) and sportfish than men (PORadj = .7, 95% CI: .6-.8). The majority (76.7%) of sportfish consumers were aware of fish advisories. However, women (PORadj = .7, 95% CI: .5-.9) and black, Indigenous, and people of color (BIPOC) (PORadj = .4, 95% CI: .2-.7) sportfish consumers were less likely to be aware of fish advisories. Compared to adults aged 18-34 years, adults ≥55 years were twice as likely to eat 1-2 fish meals (vs. less than 1 fish meal) per week (PORadj = 2.3, 95% CI: 1.8-2.9). Conclusion Findings indicate that half of all Wisconsinites consumed less fish than recommended by Wisconsin fish advisories, and women and BIPOC respondents were less likely to be aware of advisories. Educational efforts are needed to improve fish consumption habits.
Transient Inverse-FIP Plasma Composition Evolution within a Solar Flare

Understanding elemental abundance variations in the solar corona provides an insight into how matter and energy flow from the chromosphere into the heliosphere. Observed variations depend on the first ionization potential (FIP) of the main elements of the Sun’s atmosphere. High-FIP elements (>10 eV) maintain photospheric abundances in the corona, whereas low-FIP elements have enhanced abundances. Conversely, inverse FIP (IFIP) refers to the enhancement of high-FIP or depletion of low-FIP elements. We use spatially resolved spectroscopic observations, specifically the Ar xiv/Ca xiv intensity ratio, from Hinode’s Extreme-ultraviolet Imaging Spectrometer to investigate the distribution and evolution of plasma composition within two confined flares in a newly emerging, highly sheared active region. During the decay phase of the first flare, patches above the flare ribbons evolve from the FIP to the IFIP effect, while the flaring loop tops show a stronger FIP effect. The patch and loop compositions then evolve toward the preflare basal state. We propose an explanation of how flaring in strands of highly sheared emerging magnetic fields can lead to flare-modulated IFIP plasma composition over coalescing umbrae which are crossed by flare ribbons. Subsurface reconnection between the coalescing umbrae leads to the depletion of low-FIP elements as a result of an increased wave flux from below. This material is evaporated when the flare ribbons cross the umbrae. Our results are consistent with the ponderomotive fractionation model for the creation of IFIP-biased plasma.