Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparative evaluation of factor- and component-based structural equation modelling approaches under (in)correct construct representations.

Structural equation modelling (SEM) has evolved into two domains, factor-based and component-based, dependent on whether constructs are statistically represented as common factors or components. The two SEM domains are conceptually distinct, each assuming their own population models with either of the statistical construct proxies, and statistical SEM approaches should be used for estimating models whose construct representations correspond to what they assume. However, SEM approaches have often been evaluated and compared only under population factor models, providing misleading conclusions about their relative performance. This is partly because population component models and their relationships have not been clearly formulated. Also, it is of fundamental importance to examine how robust SEM approaches can be to potential misrepresentation of constructs because researchers may often lack clear theories to determine whether a factor or component is more representative of a given construct. Addressing these issues, this study begins by clarifying several population component models and their relationships and then provides a comprehensive evaluation of four SEM approaches - the maximum likelihood approach and factor score regression for factor-based SEM as well as generalized structured component analysis (GSCA) and partial least squares path modelling (PLSPM) for component-based SEM - under various experimental conditions. We confirm that the factor-based SEM approaches should be preferred for estimating factor models, whereas the component-based SEM approaches should be chosen for component models. Importantly, the component-based approaches are generally more robust to construct misrepresentation than the factor-based ones. Of the component-based approaches, GSCA should be chosen over PLSPM, regardless of whether or not constructs are misrepresented.
Effect of varicocele on sperm DNA damage: A systematic review and meta‐analysis

The updated meta‐analysis was conducted to further verify the effect of varicocele on sperm DNA damage, supplying clinicians and researchers with high‐grade evidence. The sperm DNA damage was evaluated by DNA fragmentation index (DFI), associated with the male fertility capability tightly. PubMed, Web of Science and Cochrane Library were searched extensively for eligible studies with the search terms: varicocele, sperm DNA and sperm DNA damage. Finally, a total of 12 studies were included in our meta‐analysis with a total of 845 patients diagnosed with varicocele and 2,377 healthy controls. A statistical difference of DFI between varicocele patients and healthy controls was found after pooling the data ((Standardised mean difference) SMD: 1.40, 95%CI: 0.83–1.98, p < . 0001), using the random effect model. We conducted subgroup analysis according to study region (Brazil and Other countries), detection methods of DFI (TUNEL, Comet, and SCSA), sample size (<50 and >50) and age (<30 and >30 years), based on substantial heterogeneity among eligible studies. The stability of pooled results was verified by sensitivity analysis. All these statistical analyses were conducted using Stata version 16.0. In conclusion, patients diagnosed with clinical varicocele had higher DFI than healthy controls, which means varicocele could impair sperm DNA, consequently the fertility potential of affected men.
Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study

OBJECTIVES: To assess the impact of antifibrinolytics in children with life-threatening hemorrhage. DESIGN: Secondary analysis of the MAssive Transfusion epidemiology and outcomes In Children study dataset, a prospective observational study of children with life-threatening bleeding events. SETTING: Twenty-four children’s hospitals in the United States, Canada, and Italy. PATIENTS: Children 0–17 years old who received greater than 40 mL/kg of total blood products over 6 hours or were transfused under activation of massive transfusion protocol. Intervention/Exposure: Children were compared according to receipt of antifibrinolytic medication (tranexamic acid or aminocaproic acid) during the bleeding event. MEASUREMENTS AND MAIN RESULTS: Patient characteristics, medications administered, and clinical outcomes were analyzed using Cox proportional hazard and Kaplan-Meier survival analysis. The primary outcome was 24-hour mortality. Of 449 patients analyzed, median age was 7 years (2–15 yr), and 55% were male. The etiology of bleeding was 46% traumatic, 34% operative, and 20% medical. Twelve percent received antifibrinolytic medication during the bleeding event (n = 54 unique subjects; n = 18 epsilon aminocaproic acid, n = 35 tranexamic acid, and n = 1 both). The antifibrinolytic group was comparable with the nonantifibrinolytic group on baseline demographic and physiologic parameters; the antifibrinolytic group had longer massive transfusion protocol duration, received greater volume blood products, and received factor VII more frequently. In the antifibrinolytic group, there was significantly less 6-hour mortality overall (6% vs 17%; p = 0.04) and less 6-hour mortality due to hemorrhage (4% vs 14%; p = 0.04). After adjusting for age, bleeding etiology, Pediatric Risk of Mortality score, and plasma deficit, the antifibrinolytic group had decreased mortality at 6- and 24-hour postbleed (adjusted odds ratio, 0.29 [95% CI, 0.09–0.93]; p = 0.04 and adjusted odds ratio, 0.45 [95% CI, 0.21–0.98]; p = 0.04, respectively). CONCLUSIONS: Administration of antifibrinolytic medications during the life-threatening event was independently associated with improved 6- and 24-hour survivals in bleeding children. Consideration should be given to use of antifibrinolytics in pediatric patients with life-threatening hemorrhage.
Presynaptic stochasticity improves energy efficiency and helps alleviate the stability-plasticity dilemma

When an action potential arrives at a synapse there is a large probability that no neurotransmitter is released. Surprisingly, simple computational models suggest that these synaptic failures enable information processing at lower metabolic costs. However, these models only consider information transmission at single synapses ignoring the remainder of the neural network as well as its overall computational goal. Here, we investigate how synaptic failures affect the energy efficiency of models of entire neural networks that solve a goal-driven task. We find that presynaptic stochasticity and plasticity improve energy efficiency and show that the network allocates most energy to a sparse subset of important synapses. We demonstrate that stabilising these synapses helps to alleviate the stability-plasticity dilemma, thus connecting a presynaptic notion of importance to a computational role in lifelong learning. Overall, our findings present a set of hypotheses for how presynaptic plasticity and stochasticity contribute to sparsity, energy efficiency and improved trade-offs in the stability-plasticity dilemma.
Stress, coping, resilience, and sleep during the COVID‐19 pandemic: A representative survey study of US adults

The COVID‐19 pandemic is a global health emergency resulting in widespread death and substantial disruption to daily life. Previous research has shown that novel disease outbreaks are associated with high stress levels and sleep impairments that lead to neuropsychiatric consequences. Therefore, it is vital to study both stress and protective factors such as coping and resilience that may hinder or help sleep quality during the COVID‐19 pandemic. Further, as gender disparities exist in sleep quality, it is important to understand the relationship between pandemic‐related stress, coping strategies, resilience, and sleep in bothgenders during the COVID‐19 pandemic.
Cheating at the Top: Trait Dominance Explains Dishonesty More Consistently Than Social Power

Power has long been associated with dishonesty. Here, we examined the contributions of personal and structural factors associated with power. Across five studies (N = 1,366), we tested the hypothesis that being dominant, more than having power and felt prestige, predicts dishonesty in incentivized tasks, moral disengagement, and breaking of Covid-19 containment rules. Dominance and dishonesty were positively associated (Study 1). Furthermore, dominance contributed to the positive relationship between occupational power and dishonesty in natural settings (Studies 2 and 5). Different types of power had inconsistent effects on dishonesty (Studies 3 and 4). Prestige was unrelated to dishonesty. Dominant individuals were overrepresented at the top, suggesting that the association between power and dishonesty may derive from self-selection processes, rather than power itself.
Harnessing an Integrated Health Communication (IHC) Framework for Campaigns: A Case of Prescription Drug Decision Making

ABSTRACT Drawing on a multiplicity of mass media and health behavior theories, we propose an integrated health communication (IHC) framework to understand and leverage the ways in which mass mediated and interpersonal sources of health information influence the public’s health behavior in the context of their prescription drug decisions. Building on the agenda setting theory, two-step flow theory, and the Health Belief Model, we dig into the interrelationships between mass media and interpersonal information sources and information seeking engagement. Employing survey methodology, our framework was tested using a sample of U.S. adults (N = 628). The major results include (a) information gained through interpersonal sources and perceived benefits of the prescription drugs positively and sequentially mediate the association between mass media exposure and intent to seek prescription drug information, (b) interpersonal health information positively moderate the mediation of mass media exposure – perceived benefits – intent to seek prescription drug information, and (c) the inexpert interpersonal information’s positive interaction effect with mass media exposure on intent to seek prescription drug information mediated through perceived benefits was greater with high expert interpersonal communication. These results impart valuable theoretical contributions and have the potential to guide integrated health communication (IHC) campaigns.
Suicide Notes, Attempts, and Attempt Lethality During Episodes of Ideation Among Suicidal Soldiers and Marines

Abstract Objective Suicide remains a significant public health problem among military personnel despite expanded suicide prevention efforts over the last two decades. It is important to understand the behavioral antecedents of suicide, including the writing of a suicide note, to inform efforts to identify imminent risk. However, the completion of a suicide note increasing the likelihood of making a suicide attempt (SA) and predicting a higher lethality SA during episodes of suicidality have not been evaluated. Method To determine whether or not the completion of a suicide note increased the likelihood of making a SA during a given episode of suicidal ideation (current or worst) and predicted a higher lethality SA, we conducted secondary data analysis with a sample of 657 help-seeking, active-duty U.S. Soldiers and Marines. We hypothesized that service members who completed a suicide note would be more likely to make a SA during that given episode of suicidality and make a higher lethality SA. Results Completion of a suicide note increased the likelihood of making a SA in both current and worst episodes of suicidal ideation. Additionally, writing a suicide note predicted making a higher lethality SA during a service member’s current episode of ideation but not their worst episode. Conclusions This is the first study to examine note-writing behavior during episodes of suicidal ideation rather than following a suicide death or attempt, demonstrating a non-trivial number (17%) had written a suicide note and this increased the likelihood of making a SA and a higher lethality SA. HIGHLIGHTS The first study of suicide notes during periods of ideation regardless of attempt. A suicide note written during an episode of ideation predicted making an attempt. A suicide note predicted making a more lethal suicide attempt.
The Quality of Interactive Behaviors in the Context of Prematurity: Fathers, Mothers, Daughters, and Sons

ABSTRACT: Objective: This study examined the quality of interaction between preterm-born preschoolers and their mothers and fathers, focusing on the role of child and parental sex. Methods: Participants included 88 preterm-born children (<37 wk gestational age) and 44 full-term–born children (≥37 wk gestational age) aged 3 1/2 years and their parents. Mother-child and father-child dyads were observed during a structured interactive task. Children's cooperation-compliance and negativity-hostility behaviors were coded using the Coding System for Mother-Child Interactions, and parents' sensitive behavior was coded using the Ainsworth Sensitivity Scale. Results: There was no association between preterm birth and the quality of child and parents' interactive behaviors. In the full-term group, fathers exhibited lower levels of sensitive behavior than mothers, but in the preterm group, both parents exhibited similar levels of sensitive behavior. Preterm boys exhibited more interactive difficulties than preterm girls, but there was no significant effect of child sex on full-term children's interactive behaviors. Children exhibited more compliance-cooperation and less negativity-hostility toward fathers than toward mothers. Conclusion: The findings suggest that prematurity in itself does not affect the quality of parent-preterm child interactive behaviors as the children enter the preschool period. Preterm boys seem to be at higher risk for interactive difficulties than girls, and thus, child sex should be considered when monitoring and examining the development of preterm children.
Evaluation of a Proposed Approach for the Determination of the Bioequivalence Acceptance Range for Narrow Therapeutic Index Drugs in the European Union

Bioequivalence (BE) of products containing narrow therapeutic index (NTI) drugs in the European Union is currently established by demonstrating that the 90% confidence interval for the ratio of the population geometric means of the test compared to the reference product’s AUC, and in certain cases Cmax, is included within the tighter acceptance range of 90.00–111.11%. An alternative criterion, consisting of narrowed limits based on the within-subject variability of the reference product, was recently proposed. Its performance for a three-period partial replicate design was tested by simulation in terms of power to show BE, type I error (T1E) and sample size requirements. A new condition, a constraint on the test-to-reference geometric mean ratio (cGMR) to be contained within the range of 90.00–111.11%, was also tested. The probability of showing BE when the products differ more than 10% was increased, but only if the reference product’s within-subject variability was moderate-to-high. The inclusion of the additional cGMR limited this. An increase in the T1E (<7%) was observed. The inclusion of the additional cGMR did not change the highest inflation of the T1E. Finally, a significant sample size reduction was observed and the inclusion of the cGMR usually did not increase the required sample size.
Single whole‐genome sequencing analysis of metastatic biopsy is sufficient for investigational treatment opportunities in cancer

Cancer is the second leading cause of death worldwide, accounting for an estimated 9.96million deaths in 2020 [1]. The global cancer burden is dominated by China, which has the largest population size worldwide [2, 3]. Cancer is a group of genetic diseases driven by a series of structural genomic changes [4]. Therefore, extensive analysis of somatic changes in cancer genomes can help us develop treatments that target changes in genomic drivers, thereby improving the life expectancy of cancer patients [5]. At present, a small number of cancer type-specific genomic targets are used asmolecular biomarkers to guide the treatment of this particular cancer type in clinical practice [6, 7]. With the arrival of precision medicine era, a variety of biomarkers based on somatic genomic changes have been developed. Based on these new biomarkers, cancer patients are divided into more and more subgroups. In other words, these somatic genomic changes are present in increasingly smaller patient subgroups. Moreover, the list of indications for tumor agnostic treatment is expected to expand rapidly because some anti-cancer drugs have been found to be active in tumor-agnostic manner [8]. Therefore, treatment guidance strategies that group patients into specific tumor subtypes may limit their treatment opportunities, and it may be difficult for patients to benefit from new developments in precision medicine. Comprehensive genomic profiling techniques such as wholegenome sequencing, whole-exome sequencing and large
Prevalence and safety of prescription medicine use during pregnancy in the Republic of Suriname in the year 2017: a pharmacoepidemiological analysis.

Background Using the claims database of the State Health Foundation from 2017, the prevalence and safety of prescription medicines given to pregnant women in Suriname (South America) have been determined. Methods Prescription rates and proportions of the total number of prescriptions were calculated, overall and stratified for subgroups of age, region of residence, major Anatomical Therapeutic Chemical - and safety classification (Australian categorization system). Data were compared with the Σ2-test and the two samples test of proportions using normal theory method; p-values <0.01 were considered statistically significant differences. Results Average prescription rates (number of prescriptions by number of patients) were 24.0, 29.7, and 32.5 in age groups 15-29, 30-44, and 45+ years, respectively (p<0.001), and 26.4, 23.0, and 14.0 in the urban-coastal, rural-coastal, and rural-interior region, respectively (p<0.001). Conclusions The use of prescription medicines was common (rates up to 40.4), ranged from antibiotics to vitamins, and most were safe. However, 3.2% (some antibiotics and antiepileptics) belonged to safety category D, carrying a definite human fetal risk. However, the potential benefits of these drugs warranted their use in pregnant women. These findings are largely in line with literature data, although future studies must verify their generalizability to the total Surinamese population.
Characteristics of Asian-American Breast Cancer Survivors Retained in a 3-Month Technology-Based Intervention

Background Technology-based intervention programs are known to be effective in approaching socially excluded groups or racial/ethnic minorities, including this specific population. However, the retention of participants in technology-based intervention studies is far more complicated and challenging compared with conventional studies targeting racial/ethnic minorities. Objective This study aimed to identify the complex characteristics of the groups within Asian American breast cancer survivors who were successfully retained in a 3-month technology-based intervention study. Methods This secondary analysis of the data from a larger ongoing intervention study included 155 Asian American breast cancer survivors. Major variables were measured using multiple instruments including the questions on characteristics of the participants, the Personal Resource Questionnaire, perceived isolation, Memorial Symptom Assessment Scale-Short Form, Cancer Behavior Inventory, 34-item Supportive Care Needs Survey Short Form, and Functional Assessment of Cancer Therapy Scale–Breast Cancer. Data analyses were done through χ2 tests, t tests, and decision tree analyses. Results The retention rates differed by subethnicity (P = .025), immigration age (P < .001), and stage of breast cancer (P = .003). The decision tree indicated four groups with the highest probability of retention: (a) those who were diagnosed with stage II, III, or IV breast cancer, (b) those who immigrated to the United States after turning 31 years old, and (c) those who had high perceived barriers. Conclusion This study provides directions for future retention strategies for technology-based interventions among Asian American breast cancer survivors. Implications for Practice Participants’ characteristics need to be considered in developing retain strategies for technology-based interventions among Asian American breast cancer survivors.
The Drunk Utilitarian Revisited: Does Alcohol Really Increase Utilitarianism in Moral Judgment?

The “drunk utilitarian” phenomenon suggests that people are more likely to accept harm for the greater good when they are under the influence of alcohol. This phenomenon conflicts with the ideas that (a) acceptance of pro-sacrificial harm requires inhibitory control of automatic emotional responses to the idea of causing harm and (b) alcohol impairs inhibitory control. This preregistered experiment aimed to provide deeper insights into the effects of alcohol on moral judgments by using a formal modeling approach to disentangle three factors in moral dilemma judgments and by distinguishing between instrumental harm and impartial beneficence as two distinct dimensions of utilitarian psychology. Despite the use of a substantially larger sample and higher doses of alcohol compared with the ones in prior studies, alcohol had no significant effect on moral judgments. The results pose a challenge to the idea that alcohol increases utilitarianism in moral judgments.
Effects of Active Video Games on Health-Related Physical Fitness and Motor Competence in Children and Adolescents With Overweight or Obesity: Systematic Review and Meta-Analysis

Background Childhood obesity is one of the most important public health problems. Active video games (AVGs) have been proposed as an attractive alternative to increase energy expenditure and are being investigated to determine their effectiveness against childhood obesity. Objective The aim of this study is to summarize the existing research and draw conclusions about the effects of AVGs on health-related physical fitness and motor competence in children and adolescents with overweight and obesity. Methods The search strategy was applied to PubMed, MEDLINE, Web of Science, and SPORTDiscus, including randomized and nonrandomized controlled trials investigating the effects of AVG programs on health-related physical fitness and motor competence in children and adolescents with overweight and obesity. To measure the risk of bias in randomized and nonrandomized controlled trials, 2 different quality assessment tools were used. In total, 15 articles met the inclusion criteria, and the variables of interest were BMI, body fat percentage, cardiorespiratory fitness (CRF), waist circumference, fat-free mass, muscular fitness, and motor competence. A meta-analysis was performed. Results Positive effects were found for BMI and body fat percentage, favoring the AVG group compared with a control group with no intervention (mean difference −0.209; 95% CI −0.388 to −0.031 vs mean difference −0.879; 95% CI −1.138 to −0.602). Positive effects seem to be observed for CRF. The effects of AVG interventions on muscular fitness, fat-free mass, waist circumference, and motor competence are unclear. Conclusions AVG programs showed positive effects on BMI, body fat percentage, and CRF. AVG could be a good strategy to combat childhood obesity.