Miracle-dz/UniFAR-FTUs huggingface dataset:
Perinatal S-Adenosylmethionine Supplementation Represses PSEN1 Expression by the Cellular Epigenetic Memory of CpG and Non-CpG Methylation in Adult TgCRD8 Mice

DNA methylation, the main epigenetic modification regulating gene expression, plays a role in the pathophysiology of neurodegeneration. Previous evidence indicates that 5′-flanking hypomethylation of PSEN1, a gene involved in the amyloidogenic pathway in Alzheimer’s disease (AD), boosts the AD-like phenotype in transgenic TgCRND8 mice. Supplementation with S-adenosylmethionine (SAM), the methyl donor in the DNA methylation reactions, reverts the pathological phenotype. Several studies indicate that epigenetic signatures, driving the shift between normal and diseased aging, can be acquired during the first stages of life, even in utero, and manifest phenotypically later on in life. Therefore, we decided to test whether SAM supplementation during the perinatal period (i.e., supplementing the mothers from mating to weaning) could exert a protective role towards AD-like symptom manifestation. We therefore compared the effect of post-weaning vs. perinatal SAM treatment in TgCRND8 mice by assessing PSEN1 methylation and expression and the development of amyloid plaques. We found that short-term perinatal supplementation was as effective as the longer post-weaning supplementation in repressing PSEN1 expression and amyloid deposition in adult mice. These results highlight the importance of epigenetic memory and methyl donor availability during early life to promote healthy aging and stress the functional role of non-CpG methylation.
Aharonov–Bohm‐inspired tomographic imaging via compressive sensing

The Aharonov–Bohm effect is a well-established quantum phenomenon that relates the behaviour of an electron not only to the local electromagnetic field but also to the associated potentials. An important consequence is that electron beams travelling through an arbitrary medium can carry information not only about the properties of the materials along with their trajectories but also about those of the entire background around them. Based on this established principle, the authors propose an inverse formulation for the estimation of a sample's magnetic permeability based on measurements of the wave function of a split electron beam. For one-dimensional distributions, the analysed concept is shown to lead to the ideal retrieval of the sample's texture for a sufficiently large number of measurements. Two- and three-dimensional permeability distributions can be successfully estimated by employing sparsification transformations associated with compressive imaging approaches. The proposed configuration and formulation may be useful in non-destructive detection and sensing of biological, chemical or ferrimagnetic samples.
An Analysis of the Transformational Leadership Style and Self-Efficacy Effects on Elementary School Teachers' Organizational Citizenship Behavior

statistics, inferential statistics, and path analysis. The research results showed that: (1) there was a direct positive effect of transformational leadership on OCB with a path coefficient value of 0.204; (2) there was a direct positive effect of self-efficacy on OCB with a path coefficient value of 0.187; and (3) there was an indirect effect of transformational leadership and self-efficacy on OCB path coefficient value of 0.354. This research concluded that transformational leadership and self-efficacy positively affected elementary school teachers' organizational citizenship behavior (OCB)
Strategic thinking: The construction and validation of an instrument

: The lack of instruments that evaluate strategic thinking and the fact that it is positively related to high levels of professional performance has led us to the development and validation of a questionnaire that allows us to measure it in an organizational context. This was done through three studies. First an exploratory study, in which 272 Human Resources (HR) professionals participated, allowed us to develop its items and analyze its psychometric properties. From it three factors were extracted: (1) systemic thinking, (2) vision towards the future and, (3) identification of new opportunities. Also, the results indicated the existence of a latent overall model of strategic thinking. Secondly, a confirmatory study, where 352 Human Resources professionals participated, intended to validate the results of the previous study. The same three factors, and a latent factor were replicated revealing that the model presented had an excellent adjustment. Furthermore, a third study was carried out in order to study the perceived relationship between strategic thinking, satisfaction, trust and customers’ retention. This study counted with the participation of 273 professionals who held positions of middle and upper management, key employees regarding the use of ST in organizations. The results of the three studies allow us to conclude that the Strategic Thinking Questionnaire is a valid instrument to analyze strategic thinking.
Does Religious Fasting Have a Protective Role against Metabolic Syndrome in Individuals Aged >50 Years?

Objective: The Christian Orthodox Church (COC) fasting is a periodic vegetarian-type diet lasting 180–200 days annually in which seafood and snails are allowed on all fasting days. Our aim was to investigate the effects of COC fasting on metabolic syndrome (MetS) in adults >50 years. Methods: One hundred seventy-six individuals participated in the study (mean age 59.7 ± 6.0 years). Eighty-nine had been following the COC fasting regime since their childhood and eighty-seven were non-fasters. Anthropometric measurements, blood samples, and nutrient intake data were collected at a scheduled appointment, during a non-fasting period. Results: Fasters had significantly higher hip circumference (102 ± 8.5 vs. 98.8 ± 7.5 cm, p = 0.009), low-density lipoprotein (LDL) cholesterol (136 ± 73 vs. 115 ± 51 mg/dL, p = 0.033), and folic acid levels (6.0 ± 4.0 vs. 3.0 ± 1.2 ng/mL, p = 0.018), as well as lower systolic blood pressure (SBP) (131 ± 13 vs. 136 ± 14 mmHg, p = 0.045), diastolic blood pressure (DBP) (80 ± 8 vs. 83 ± 7 mmHg, p = 0.007), glucose (87 ± 16 vs. 93 ± 25 mg/dL, p = 0.039), and triglycerides (143 ± 94 vs. 175 ± 84 mg/dL, p = 0.040). Fasters had significantly less intake of calories (1493.65 ± 363.74 vs. 1614.65 ± 426.28 kcal, p = 0.044) and fat (81.17 ± 25.47 vs. 90.74 ± 24.75 g, p = 0.012), whereas they also consumed significantly less vitamin A-retinol, vitamin B2, vitamin B12, vitamin E, folic acid, pantothenic acid, calcium, phosphorus, zinc, and significantly more vitamin C (p < 0.005 for all comparisons). BP was significantly higher in non-fasters (44.8 vs. 22.5%, p = 0.002), whereas MetS was more frequently present in non-fasters vs. fasters, with a marginal level of significance (35.6 vs. 22.5%, p = 0.055). Conclusions: COC fasting may affect beneficially MetS prevalence in individuals >50 years, although future research is needed before reaching definite conclusions.
Pityopsis ruthii: An Updated Review of Conservation Efforts for an Endangered Plant

Pityopsis ruthii (Small) Small, Ruth’s golden aster, is an endangered Asteraceae species that grows in the riparian zone along small sections of two rivers in the Southern Appalachian Mountains of the United States of America (USA). Since 1985, the species has been listed under the Endangered Species Act by the United States Fish and Wildlife Service (USFWS). The mission of the USFWS is to conserve, protect, and enhance fish, wildlife, and plants and their habitats for the continued benefit of the American people. The agency provides national leadership in the recovery and conservation of imperiled plant species by working with the scientific community to protect important habitats, increase species’ populations, and identify and reduce threats to species survival with the goal of removal from federal protection. Over the past 35 years, research efforts have focused on studies designed to delineate the range and size of populations, determine habitat requirements, reproductive and propagation potential, and understand the demographic, ecological, and genetic factors that may increase vulnerability to extinction for P. ruthii. Cooperative partnerships have driven the completion of actions called for in the strategy to recover P. ruthii, and in this review, we highlight these efforts within the context of species conservation.
Improving Overall Survival and Quality of Life in Patients with Prostate Cancer and Neuroendocrine Tumors Using 177Lu-iPSMA and 177Lu-DOTATOC: Experience after 905 Treatment Doses

177Lu-iPSMA is a novel radioligand developed at ININ-Mexico with a high affinity for the PSMA protein heavily expressed in cancer cells of approximately 95% of patients with metastatic castration-resistant prostate cancer (mCRPC). 177Lu-DOTATOC is a patent-free radioligand, molecularly recognized by somatostatin receptors (SSTR-2) overexpressed in cancer cells of about 80% of patients with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NET). This translational research aimed to determine the efficacy and safety of 177Lu-iPSMA and 177Lu-DOTATOC developed as GMP pharmaceutical formulations for treating progressive and advanced mCRPC and NET. One hundred and forty-five patients with mCRPC and one hundred and eighty-seven subjects with progressive NET (83% GEP-NET and 17% other NET), treated with 177Lu-iPSMA and 177Lu-DOTATOC, respectively, were evaluated. Patients received a mean dose of 7.4 GBq per administration of 177Lu-iPSMA (range 1–5 administrations; 394 treatment doses) or 177Lu-DOTATOC (range 2–8 administrations; 511 treatment doses) at intervals of 1.5–2.5 months. Efficacy was assessed by SPECT/CT or PET/CT. Results were stratified by primary tumor origin and number of doses administered. Patients with mCRPC showed overall survival (OS) of 21.7 months with decreased radiotracer tumor uptake (SUV) and PSA level in 80% and 73% of patients, respectively. In addition, a significant reduction in pain (numerical scale from 10–7 to 3–1) was observed in 88% of patients with bone metastases between one and two weeks after the second injection. In the GEP-NET population, the median progression-free survival was 34.7 months, with an OS of >44.2 months. The treatments were well tolerated. Only ten patients experienced grade ≥ 3 myelosuppression (3% of all patients). The observed safety profiles and favorable therapeutic responses demonstrated the potential of 177Lu-iPSMA and 177Lu-DOTATOC to improve overall survival and quality of life in patients with progressive and advanced mCRPC and NET.
Difficulties encountered by teachers in using storytelling to teach very young learners

Storytelling is widely applied in second language teaching, especially to Very Young Learners (VYLs), as this teaching technique is believed to be highly effective. However, storytelling application in VYLs classrooms may be challenging since these learners possess unique characteristics in terms of second language acquisition, which might cause a variety of difficulties for teachers. This paper examines the difficulties Vietnam - USA Society English Center’s teachers encounter during their storytelling application to teach VYLs. Accordingly, 60 teachers at the language school, who were selected based on their teaching experience, participated in the study. An online survey was carried out in order to find out the participants’ opinions on storytelling application challenges regarding the teaching method, the learners’ characteristics, and the materials. Additionally, in-depth interviews were conducted with twelve randomly chosen teachers to better understand their rationale and suggestions for those difficulties. For data analysis, descriptive statistics were calculated for questionnaire information while the qualitative responses were transcribed and put into themes. The results revealed that the participants encountered certain challenges while delivering storytelling lessons which mainly stemmed from the students and other subjects namely teachers and materials. The findings from this study may help teachers to mitigate the challenges of the storytelling lesson.
Early Brain Injury and Neuroprotective Treatment after Aneurysmal Subarachnoid Hemorrhage: A Literature Review

Early brain injury (EBI) subsequent to subarachnoid hemorrhage (SAH) is strongly associated with delayed cerebral ischemia and poor patient prognosis. Based on investigations into the molecular mechanisms underlying EBI, neurovascular dysfunction resulting from SAH can be attributed to a range of pathological processes, such as microvascular alterations in brain tissue, ionic imbalances, blood–brain barrier disruption, immune–inflammatory responses, oxidative stress, and activation of cell death pathways. Research progress presents a variety of promising therapeutic approaches for the preservation of neurological function following SAH, including calcium channel antagonists, endothelin-1 receptor blockers, antiplatelet agents, anti-inflammatory agents, and anti-oxidative stress agents. EBI can be mitigated following SAH through neuroprotective measures. To enhance our comprehension of the relevant molecular pathways involved in brain injury, including brain ischemia–hypoxic injury, neuroimmune inflammation activation, and the activation of various cell-signaling pathways, following SAH, it is essential to investigate the evolution of these multifaceted pathophysiological processes. Facilitating neural repair following a brain injury is critical for improving patient survival rates and quality of life.
Theoretical framework for the RUNO personality typology based on the Circumplex of Personality Metatraits

: The current literature on personality types—understood as basic configurations of the Big Five’s personality traits—provides inconsistent results. The most commonly reported, three-type RUO (Resilient-Undercontrolled-Overcontrolled) solution is not definitive, as other solutions are also" often obtained. The current paper starts from reviewing and discussing the inconsistencies found in the previous results as well as in the RUO typology itself. The prevalence of an exploratory orientation in research on personality type was interpreted as the main cause of these problems. Then, we proposed a solution by using the Two Factor Model of personality and its extension—the Circumplex of Personality Metatraits—as the theoretical foundation for a four-type RUNO typology (Resilient-Undercontrolled-Nonresilient-Overcontrolled). The paper presents the RUNO personality typology and its theoretical consequences – in particular, we argue that the RUNO (a) is the most theoretically justified, and therefore, empirically expected solution, (b) allows us to explain why the three-type RUO solution is so commonly obtained, and (c) helps to solve some other problems that have arisen in the literature (e.g., with “typeness”).
Active Ingredients from Chinese Medicine for Combination Cancer Therapy

Combination therapy against cancer has gained increasing attention because it can help to target multiple pathways to tackle oncologic progression and improve the limited antitumor effect of single-agent therapy. Chinese medicine has been studied extensively in cancer therapy and proven to be efficacious in many cases due to its wide spectrum of anticancer activities. In this review, we aim to summarize the recent progress of active ingredients from Chinese medicine (AIFCM) in combination with various cancer therapeutic modalities, including chemotherapy, gene therapy, radiotherapy, phototherapy and immunotherapy. In addition to highlighting the potential contribution of AIFCM in combination cancer therapy, we also elucidate the underlying mechanisms behind their synergistic effect and improved anticancer efficacy, thereby encouraging the inclusion of these AIFCM as part of effective armamentarium in fighting intractable cancers. Finally, we present the challenges and future perspectives of AIFCM combination therapy as a feasible and promising strategy for the optimization of cancer treatment and better clinical outcomes.
PREVALENCE OF THE GASTROINTESTINAL HELMINTHS IN BOVINE POPULATION IN DIFFERENT ZONES OF RAWALPINDI DISTRICT OF PUNJAB, PAKISTAN

Gastrointestinal parasites are responsible for heavy economic and production lossesin bovines. The present study was conducted to determine the prevalence of gastrointestinal (GI)helminths of bovine in different zones of Rawalpindi district. Study area was divided into fourdifferent zones. Feacal samples (n=670) were collected and examined through coprologicalexamination techniques. Out of examined samples, 158 were found to be positive for the GI helminths.The overall prevalence of GI helminths recorded was 23.58 %. In cattle the prevalence was 25.87 %whereas, in buffaloes it was 20.83 %. The prevalence percentages of nematodes, trematodes andcestodes was 17.46, 4.78 and 1.34%, respectively. Maximum prevalence was observed during summerand was the highest in the month of June. Prevalence was higher in adult and females as compared toyoung and males. It was concluded that specie, age and season are important factors which influencethe prevalence of GI helminths in bovine.
From Gymnastics to Virtual Nonholonomic Constraints: Energy Injection, Dissipation, and Regulation for the Acrobot

In this article, we study virtual nonholonomic constraints (VNHCs), which are relations between the generalized coordinates and momenta of a mechanical system that can be enforced via feedback control. We design a constraint which emulates gymnastics giant motion in an acrobot and prove that this constraint can inject or dissipate energy based on the sign of a design parameter. The proposed constraint is tested both in simulation and experimentally on a real-world acrobot, demonstrating highly effective energy regulation properties and robustness to a variety of disturbances.
Robust Inference for Panel Quantile Regression Models with Individual Fixed Effects and Serial Correlation

This paper develops cluster robust inference methods for panel quantile regression (QR) models with individual fixed effects, allowing arbitrary temporal correlation structure within each individual. The conventional QR standard errors assuming independent outcomes can seriously underestimate the uncertainty of estimators and therefore overestimate the significance of effects when outcomes are serially correlated. This is analogous to the well-known size distortion in the OLS estimation of panel data, illustrated by Bertrand, Duflo, and Mullainathan (2004). Thus, we propose a clustered covariance matrix estimator that solves this problem in panel QR models. In addition, we develop two cluster robust tests and establish their asymptotic properties. Unlike OLS, there is no known data transformation in quantile models that effectively remove individual fixed effects, so we use recent advancements in panel QR literature to deal with the incidental parameters problem. Simulation studies show that cluster robust tests have good finite sample properties. We demonstrate the usefulness the new methods using an empirical capital structure example. The results document evidence of strong heterogeneity of the economic drivers across the conditional distribution of market debt ratio.
Non-iterative low-multilinear-rank tensor approximation with application to decomposition in rank-(1,L,L) terms

Computing low-rank approximations is one of the most important and well-studied problems involving tensors. In particular, approximations of low multilinear rank (mrank) have long been investigated by virtue of their usefulness for subspace analysis and dimensionality reduction purposes. The first part of this paper introduces a novel algorithm which computes a low-mrank tensor approximation non-iteratively. This algorithm, called sequential low-rank approximation and projection (SeLRAP), generalizes a recently proposed scheme aimed at the rank-one case, SeROAP. We show that SeLRAP is always at least as accurate as existing alternatives in the rank-(1,L,L) approximation of third-order tensors. By means of computer simulations with random tensors, such a superiority was actually observed for a range of different tensor dimensions and mranks. In the second part, we propose an iterative deflationary approach for computing a decomposition of a tensor in low-mrank blocks, termed DBTD. It first extracts an initial estimate of the blocks by employing SeLRAP, and then iteratively refines them by recomputing low-mrank approximations of each block plus the residue. Our numerical results show that, in the rank-(1,L,L) case, this remarkably simple scheme outperforms existing algorithms if the blocks are not too correlated. In particular, it is much less sensitive to discrepancies among the block's norms.
Ophiuroids from the Upper Jurassic of Kuyavia and the Kraków-Częstochowa Upland, Poland

: Loba, M. and Radwańska, U. 2022. Ophiuroids from the Upper Jurassic of Kuyavia and the Kraków-Często-chowa Upland, Poland. Acta Geologica Polonica , 72 (4), 391–412. Warszawa. Ophiuroids from the Upper Jurassic marine deposits (upper Oxfordian–lower Kimmeridgian) of southern and north-western Poland have been studied in two sections: Zalas quarry in the Kraków-Częstochowa Upland in southern Poland and Wapienno/Bielawy quarries in the Kuyavia region of north-western Poland. Described herein are nine taxa belonging to five genera (one new to science): Alternacantha Thuy and Meyer, 2013; Dermocoma Hess, 1964; Ophiobartia Loba gen. nov.; Ophioderma Müller and Troschel, 1840; Ophiotreta Verrill, 1899, and three families: Ophiacanthidae and Ophiodermatidae (both of Ljungman, 1867), and Ophiotomidae Paterson, 1985. Only a few representatives of some of these taxa have previously been reported from the Jurassic of Poland. One species, Ophiobartia radwanskii Loba, is established as new . The ophiuroid material recognized from both Polish localities is close to those described from Western Europe at family or even genus level. Both studied ophiuroid assemblages from Zalas and Wapienno/Bielawy show similarities, being dominated by the cosmopolitan species Ophioderma spectabile Hess, 1966, and by different species of Dermocoma . The recognized ophiuroid assemblages represent a rather shallow-water environment.