Miracle-dz/UniFAR-FTUs huggingface dataset:
Hand Corticosteroid Injections in Patients on “Blood Thinners”

Background: Our study aims to identify any influence that anticoagulation and antiplatelet (“blood thinner”) medications have on hand and wrist corticosteroid injection complication rates. Methods: This retrospective chart review looked at patients between the ages of 18 and 89 years who received corticosteroid injections in the hand or wrist between 2013 and 2017, noting anticoagulation and antiplatelet use, demographics, injection placement, and surgical intervention. Results: Only 152 (20.9%) of the 726 diagnoses that were treated needed eventual surgical intervention. There were 12 overall reported complications after 1473 injections (0.8%). There were 6 complications after 433 injections (1.6%) placed in patients on blood thinners and 6 complications after 1040 injections (0.6%) placed in patients not on blood thinners. Conclusions: With the complication rate of corticosteroid injections being so low, even in patients taking “blood thinners,” the fear of adverse reactions should not preclude a physician from using this treatment modality to prevent surgical intervention.
Even a Previous Light-Active Physical Activity at Work Still Reduces Late Myocardial Infarction and Stroke in Retired Adults Aged>65 Years by 32%: The PROOF Cohort Study

Background: Work may contribute significantly to daily physical activity (PA) and sedentary behavior (SB). Physical inactivity and SB at work might be two major risk factors for premature morbidity. Therefore, the aim of this research was to describe self-reported past PA and SB at work and during leisure time within the PROOF cohort subjects, and to determine consequences of PA and SB on late health of these now retired workers. Material and Methods: The PROOF cohort study was used to prospectively allow assessment of the predictive value of PA and SB at work and during leisure time among a healthy retired French population, with regard to cardiovascular and cerebrovascular events. PA (MET-h/week) and SB (h/d) were assessed using the Population Physical Activity Questionnaire (POPAQ) and the modified Global Physical Activity Questionnaire (GPAQ). Odds ratios (ORs with 95% CIs) for cardiovascular and cerebrovascular events were associated with each level of PA at work: light (<3 METs), moderate (3–5.9 METs), vigorous (≥6 METs) and were compared to SB at work. Results: Out of the 1011 65-year-old subjects initially included, the 15-year follow-up has been currently completed for 688 (68%) subjects; 89 deaths (all-cause mortality, 9%) and 91 fatal and non-fatal cardiovascular and cerebrovascular events (9%), were reported. An active work (light, moderate, or vigorous intensity) was associated with a 21% reduced risk of cardiovascular (myocardial infarction) and cerebrovascular events (stroke) (OR = 0.79, 95% CI: 0.32–0.91, p < 0.02) compared to sedentary work. This relationship was already significant for light intensity work (32%; i.e., OR = 0.68, 95% CI: 0.31–0.87, p < 0.02). Conclusion: There is strong causal evidence linking PA and SB at work with late cardiovascular and cerebrovascular disease. All in all, the risk for onset of myocardial infarction and stroke was lower among those who had a previous active work compared to those with previous sedentary work. Even previous light active work produced substantial health benefits. Clinical Trial Registration: www.ClinicalTrials. gov, identifier: NCT00759304.
Activating constructive employee behavioural responses in a crisis: Examining the effects of pre‐crisis reputation and crisis communication strategies on employee voice behaviours

This study explores how organizational management can promote employee voice behaviours, as positive behavioural reactions with constructive ideas, in responding to organizational crisis. Using an experimental study (N = 640) among full-time employees in the United States, the study found that precrisis internal reputation and crisis communication strategies—accommodative response and stealing thunder—positively and directly affected constructive employee voice behaviours in a crisis situation. Furthermore, the study revealed how post-crisis internal reputation mediates the influences of pre-crisis internal reputation and stealing thunder on positive/constructive and negative/destructive employee voice behaviours. The findings of this study contribute to the theoretical development of crisis communication in the internal context of an organization, especially with respect to employee voice behaviours. The study also highlights an important practical implication for crisis managers who can activate and promote positive employee behaviour voices, thereby influencing leadership's strategic decision-making in an organizational crisis.
Liquid Biopsy Analysis of FGFR3, TERT Promoter and STAG2 Hotspot Mutations for Disease Surveillance in Bladder Cancer

Patients with non-muscle invasive bladder cancer (NMIBC) are followed by frequent cystoscopies. Innovative approaches partly replacing cystoscopy (uncomfortable, expensive, low sensitive procedure) are demanded. The current study aims to establish a fast, reliable, non-invasive, and inexpensive procedure for NMIBC patient surveillance. Liquid biopsy is a reliable source of biomarkers for cancer patient monitoring. Urine is the most suitable biological liquid to search for bladder cancer biomarkers. Cell-free DNA in urine represents tumor-related mutations for several cancers, including the bladder. We investigated mutations in FGFR3, TERT promoter, and STAG2 as markers for diagnostics and follow-up in NMIBC. Digital PCR was used to detect mutations in urine-derived cell-free DNA. The sensitivity and specificity of the markers in relation to clinical outcomes served as criteria of the assay efficiency. The sensitivity with a single marker (TERT) reached 87%, with a specificity of 77%. Combining two biomarkers (TERT+FGFR3) increased the specificity of the assay to 100% with a sensitivity of 72%. Different mutational status of STAG2 can indicate NMIBC presence or recurrence. Therefore, applying the suggested combination of biomarkers with simple detection procedures to larger patient cohorts will allow developing procedures for BC detection and surveillance with optimal sensitivity and specificity. Based on the results of this proof-in-concept study, we conclude that this simple, fast and inexpensive assay can add diagnostic and prognostic value to cystoscopy/cytology analysis of NMIBC patients.
THE PERSISTENTLY INFECTED BOVINE VIRAL DIARRHEA VIRUS INDIVIDUAL: PREVALENCE, VIRAL SURVIVAL, AND IMPACT WITHIN COMMERCIAL FEEDING SYSTEMS

Bovine viral diarrhea virus (BVDV) has emerged as one of the most important infectious diseases in cattle. One particular important manifestation, after successfully establishing an in utero infection of the fetus during the first trimester, is the development of a persistently-infected BVDV (PI-BVDV) calf. Persistently infected BVDV animals are a continuous source of virus and can shed the virus in virtually all secretions and excretions, including nasal discharges, saliva, semen, urine, tears, milk, and, to a lesser extent, feces. The objectives of this research were to determine: 1) the effects of short term exposure (13  18 days on feed (DOF)) to PIBVDV feeder cattle; 2) the outcome of testing and removing PI-BVDV feeder calves at time of feedlot arrival on health, performance, and carcass characteristics; 3) the survival of BVDV on materials associated with livestock production; and 4) characterization of testing and longitudinal prevalences for PI-BVDV beef cattle. Testing and removing PI-BVDV calves at 13 to 18 DOF was too late to remove a morbidity effect due to PI-BVDV exposure. However, mortality, performance, and carcass characteristics were not different in cattle exposed to PI-BVDV cattle. Additionally, there were no harmful outcomes when newly arrived feeder cattle were exposed to a PI-BVDV animal for one to two days following feedlot entry. A non-cytopathic, Type 1b, BVDV was capable of surviving after application to various materials used in livestock production. BVDV tended to survive longer on non-porous materials than porous materials. When in the presence of mucus, BVDV was protected from degradation for longer periods of time than when not in the presence of mucus. There was no difference in overall PI-BVDV prevalence within cattle sampled in 2006 and 2007. Cattle that weighed less than 300 lbs. had a greater likelihood of being PI-positive than cattle with increased weights. Several months of the year had a greater likelihood of having PI-positive animals. Based on operation, cow-calf and stocker operations had a greater likelihood of having PI-positive animals than did feedlot operations. THE PERSISTENTLY INFECTED BOVINE VIRAL DIARRHEA VIRUS INDIVIDUAL: PREVALENCE, VIRAL SURVIVAL, AND IMPACT WITHIN COMMERCIAL FEEDING SYSTEMS
Information Geometry for Regularized Optimal Transport and Barycenters of Patterns

Abstract We propose a new divergence on the manifold of probability distributions, building on the entropic regularization of optimal transportation problems. As Cuturi (2013) showed, regularizing the optimal transport problem with an entropic term is known to bring several computational benefits. However, because of that regularization, the resulting approximation of the optimal transport cost does not define a proper distance or divergence between probability distributions. We recently tried to introduce a family of divergences connecting the Wasserstein distance and the Kullback-Leibler divergence from an information geometry point of view (see Amari, Karakida, & Oizumi, 2018). However, that proposal was not able to retain key intuitive aspects of the Wasserstein geometry, such as translation invariance, which plays a key role when used in the more general problem of computing optimal transport barycenters. The divergence we propose in this work is able to retain such properties and admits an intuitive interpretation.
Transformation of Child – Worthy City Policy In Pekanbaru

This article aims to illustrate the transformation of Child – Worthy City (KLA) in Pekanbaru. Involved in it. The author considers the qualitative approach as the most possible approach to describe the transformation of Child – Worthy City policy in Pekanbaru. Through a qualitative approach, the authors made observations, interviews with a number of informants (namely the Pekanbaru City government and Pekanbaru City DPRD members), and studied all the documentation obtained from the Pekanbaru City Women's and Children's Protection and Empowerment Office relating to the City Decent Children Policy in the City Pekanbaru. So the author can describe that the Pekanbaru City Government has made various efforts in transforming of Child Friendly Cities Policy. However, thepolicy to develop Child – Worthy City in Pekanbaru City is quite imbalance. The policy mentioned inequality towards Pekanbaru City Regulation (PERDA) that has not yet been formulated through the Child – Worthy City development. In order this imbalance becomes one of the most urgent obstacles in transforming the policy of Child-Friendly Cities in Pekanbaru City.
Number of Excised Lymph Nodes Has No Impact on Relapse and Survival in Patients With Stage III Melanoma.

BACKGROUND Even though both the involvement of regional lymph nodes and the number of metastatic lymph nodes are regarded as major determinants of survival in cutaneous melanoma, the extent of node dissection has been analyzed as an independent prognostic indicator in only a few studies. This study aims to determine how the extent of lymph node excision (EN) might predict the disease relapse and survival in melanoma. METHODS A total of 317 patients with stage III melanoma were included in the study and reviewed retrospectively. The patients were divided into 2 groups based on the number of the excised lymph nodes: EN1 for fewer than 10 and EN2 for 10 or more lymph nodes removed. RESULTS The median number of positive nodes was 1 (range, 1-32). The largest group was N1 (52.4%), which was followed by N2 (29.6%) and N3 (18%). The median number of EN was 13 (range, 1-73). The patients were allocated to EN1 and EN2 as follows: 31.9% and 68.1%, respectively. The rates of EN2 patients were 62.2%, 72.2%, and 78.2% in N1, N2, and N3, respectively. For all patients, the estimated 5- and 10-year relapse-free survival rates were 41% and 39%, respectively; and the estimated 5- and 10-year overall survival rates were 51% and 42%, respectively. Extension of lymph node excision was found to be not prognostic for relapse and survival (P = 0.55 and P = 0.88, respectively). CONCLUSIONS Extension of lymph node excision has no impact on relapse and survival of stage III cutaneous melanomas.
Principals and District Leaders Navigating the Marketplace: Lessons From Texas, New York, and Pennsylvania

Due to the growth of school choice across the United States as well as declining enrollment in some districts, schools are experiencing increasing competition for students. As a result, principals and school district leaders in high-choice districts are now expected to develop strategies such as branding, marketing, and community outreach to attract and retain students. Yet, there is a lack of literature exploring whether principals and district leaders are prepared to navigate these competitive spaces effectively, ethically, and equitably. Our study examines how principals and district leaders experience competition as well as their perspectives and practices in terms of marketing their school. In order to understand this complex process, we juxtapose theoretical perspectives on family and community partnerships with more mainstream market theories and critiques. We then apply these frameworks on three unique cases along the Texas–Mexico border, a low-income area of New York City, and rural Pennsylvania. Data were collected primarily through interviews with principals, superintendents, and other district leaders. We find that in all three cases, principals and district leaders felt they had to engage in marketing practices. Yet, some principals clearly embraced market-based rhetoric while others viewed strong community engagement as a means for maintaining enrollment. The three cases also reveal critical equity issues regarding principal experience, district support, and preexisting market hierarchies. We conclude with a discussion considering how districts can create equitable conditions for marketing and how leadership preparation programs can prepare principals and school leaders to work ethically and effectively in competitive spaces.
Analysis Relative Strength Index and Earning per Share on Stock Price (Survey on LQ 45 Companies for the 2014-2016 Period)

: This study aims to determine the effect of the relative strength index and earnig per share on stock prices. The research design used is a quantitative approach with a population of all companies in the LQ45 category listed on the Indonesia stock exchange for the 2013-2016 periode. The sampling technique used was purposive sampling. Based on the criteria set, 13 companies were obtained. The results showed that the relative strength index and earning per share had a significant positive effect on stock prices in the LQ45 company on the Indonesia stock exchange for the period 2013-2016.
Life Satisfaction and Noncognitive Skills: Effects on the Likelihood of Unemployment

Psychological measures are gaining recognition as important determinants of labor performance. This paper demonstrates that people reporting greater subjective well‐being (SWB) are causally less likely to be unemployed in the future. The relation exhibits a meaningful magnitude relative to the mean unemployment rate and other determinants. The analysis is based on a longitudinal survey of German households over the period 1996‐2013 (German Socio‐Economic Panel). Analyses include separate dynamic and fixed‐effects regressions, and two instrumental variable approaches. Together, this sample and set of analyses, makes it possible to assess the relation for previously unstudied groups and to assess different mechanisms. Indeed the relation exhibits considerable heterogeneity. It is quadratic and substantially greater for students and people that are presently unemployed (compared to their counterparts). Fixed effects regressions indicate that SWB affects future unemployment in part through within‐person changes in the Big‐Five personality traits (e.g., conscientiousness or emotional stability) but not cognitive ability. The results imply SWB may be used as a proxy for alternative psychological predictors of performance, which is important because SWB is more broadly available than many alternatives (e.g., the Big Five). What is more, policy makers have additional reasons to promote SWB.
Pandemics Depress the Economy, Public Health Interventions Do Not: Evidence from the 1918 Flu

We study the impact of non-pharmaceutical interventions (NPIs) on mortality and economic activity across U.S. cities during the 1918 Flu Pandemic. The combination of fast and stringent NPIs reduced peak mortality by 50 percent and cumulative excess mortality by 24 to 34 percent. However, while the pandemic itself was associated with short-run economic disruptions, we find that these disruptions were similar across cities with strict and lenient NPIs. NPIs also did not worsen medium-run economic outcomes. Our findings indicate that NPIs can reduce disease transmission without further depressing economic activity, a finding also reflected in discussions in contemporary newspapers.
Sand Fly–Associated Phlebovirus with Evidence of Neutralizing Antibodies in Humans, Kenya

We describe a novel virus, designated Ntepes virus (NPV), isolated from sand flies in Kenya. NPV has the characteristic phlebovirus trisegmented genome architecture and is related to, but distinct from, Gabek Forest phlebovirus. Diverse cell cultures derived from wildlife, livestock, and humans were susceptible to NPV, with pronounced permissiveness in swine and rodent cells. NPV infection of newborn mice caused rapid and fatal illness. Permissiveness for NPV replication in sand fly cells, but not mosquito cells, suggests a vector-specific adaptation. Specific neutralizing antibodies were found in 13.9% (26/187) of human serum samples taken at the site of isolation of NPV as well as a disparate site in northeastern Kenya, suggesting a wide distribution. We identify a novel human-infecting arbovirus and highlight the importance of rural areas in tropical Africa for arbovirus surveillance as well as extending arbovirus surveillance to include hematophagous arthropods other than mosquitoes.
Co-incidence Analysis of Changes in Flood Magnitude and Shifts in Flood Timing in a Large Tropical Pluvial River Basin

Abstract. Understanding trends in flood severity and the persistence in peak discharge timing along a vast river network is vital for basin-scale flood risk management and reinsurance purposes. While earlier studies have primarily focused on analysis of either trends in floods or its seasonality independently, here for the first time, we assess coincidence of changes in peak discharge and shifts in its timing in one of the largest peninsular rivers (drainage area of 141 589 km2), Mahanadi River Basin (MRB), in India during 1970–2016. Our research is motivated by the recent six major consecutive floods over MRB during the years 2001, 2003, 2006, 2008, 2011, and 2013. We analyze flood properties using peak fluvial discharge indicators, Monsoonal (from June 1–end of September, during the Indian summer monsoon period), Maxima Flood (MMF) and Peak over Threshold Flood (POTF) events. While we find a blend of (insignificant) up/downward trends in flood magnitude at Upper MRB (Region I), the middle reaches of the basin (Region II) showed an upward trend in flood magnitude with a larger number of sites detect significant trends in floods for the POTF events. Although the average dates of peak discharge in the basin are concentrated in August, notwithstanding the nature of flood samplings, a delayed (or earlier) shift in flood timing is apparent for most of sites. Further, we detect potential hotspots, where up/downward trends in flood magnitude coincide with early (or delayed) dates of flood occurrences. Based on observational evidence, here we show that up to one-third of sites show an up/downward trend in peak discharge with a distinct shift in the flood timing throughout the MRB. The outcomes of the study call for developing efficient adaptation strategies to ensure regional flood resilience since variations in the peak discharge timing should not be confounded with (insignificant) changes in its magnitude.
PANCREAS DIVISUM AND RECURRENT PANCREATITIS: LONG-TERM RESULTS OF MINOR PAPILLA SPHINCTEROTOMY

Abstract Background and aims: Pancreas divisum (PD) is the most common congenital variant of the pancreatic ductal system and a potential cause of acute recurrent pancreatitis (ARP). Endoscopic therapy is a therapeutic option for symptomatic PD, but there is limited data on long-term results. We aimed to assess the effect of minor papilla endoscopic sphincterotomy (MiES) in the setting of ARP in patients with PD. Methods: Consecutive patients treated by MiES were included. Clinical data, including gender, age, smoking and drinking habits, number of episodes of acute pancreatitis (AP) as well as technical data pertaining to the endoscopic therapy were reviewed. Patients available for follow-up were contacted to assess the long-term impact of MiES using the Patient’s Global Impression of Change (PGIC) questionnaire. Results: A total of 138 patients with PD including 77 patients with ARP underwent MiES; 48 patients were available for long-term follow-up using the PGIC score, with a mean follow-up period of 9.7 years. Procedure-related adverse events developed in 10 cases (12.9%): 5 post-MiES delayed bleeding and 5 mild pancreatitis. MiES was clinically successful in 35 patients (72.9%) who did not experience any more episodes of AP. Improvement in quality of life (PGIC ≥6) occurred in 41/48 patients (85.4%). On multivariate analysis, stenosis of the MiES was the only predictive factor for increased risk of recurrent pancreatitis after initial therapy. Conclusion: MiES resulted an efficient treatment for ARP in patients with PD with clinical benefit, patient satisfaction and improved quality of life even at long-term follow-up.