Miracle-dz/UniFAR-FTUs huggingface dataset:
Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Group Format in Spain: Results of a Noninferiority Randomized Controlled Trial at 15 Months after Treatment Onset

Evidence-based psychological treatments (EBPT) are an effective and efficient solution for the treatment of emotional disorders (EDs). However, their implementation and dissemination are not yet widespread. The Unified Protocol for Transdiagnostic Treatment of EDs (UP), applied in a group format, could be an effective option to be implemented in specialized public mental health services in Spain. The sample consisted of 533 users of public specialized mental health centers (77.3% women), with a mean age of 42.0 years ( SD = 12.62 ), who were randomized to the UP in group format condition ( n = 277 ) or treatment as usual (specific cognitive behavioral therapy for each disorder in individual format, n = 256 ). Assessments were performed at preintervention (T1) and at 3, 6, 9 and 15 months after treatment onset (T2, T3, T4, and T5, respectively). The results showed a main effect of time in both conditions for all primary outcomes ( p < 0.05 ) and no statistically significant Time ∗ Condition interaction. Similarly, the noninferiority tests showed that UP results were statistically noninferior compared to TAU. Effect sizes for psychological variables were higher in the UP condition at T5, even though the differences were not statistically significant. Statistically significant differences ( p < 0.05 ) in the evolution of the diagnostic criteria and comorbidity were found, with the highest percentage of patients no longer meeting main and secondary diagnosis criteria in the UP condition at all assessment moments (except for secondary diagnosis at T3). The results showed statistically significant differences in treatment retention between conditions at T5, being the UP condition the one with less dropouts. Finally, participants in the group UP condition showed high satisfaction with the treatment. The UP is an EBPT that has been shown to be effective when applied in groups and may represent an efficient option for its implementation in public mental health services in Spain. This trial is registered with NCT03064477.
Test of a Modified Infrared-Only ABI Cloud Mask Algorithm for AHI Radiance Observations

AbstractAssimilation of infrared channel radiances from geostationary imagers requires an algorithm that can separate cloudy radiances from clear-sky ones. An infrared-only cloud mask (CM) algorithm has been developed using the Advanced Himawari Imager (AHI) radiance observations. It consists of a new CM test for optically thin clouds, two modified Advanced Baseline Imager (ABI) CM tests, and seven other ABI CM tests. These 10 CM tests are used to generate composite CMs for AHI data, which are validated by using the Moderate Resolution Imaging Spectroradiometer (MODIS) CMs. It is shown that the probability of correct typing (PCT) of the new CM algorithm over ocean and over land is 89.73% and 90.30%, respectively and that the corresponding leakage rates (LR) are 6.11% and 4.21%, respectively. The new infrared-only CM algorithm achieves a higher PCT and a lower false-alarm rate (FAR) over ocean than does the Clouds from the Advanced Very High Resolution Radiometer (AVHRR) Extended System (CLAVR-x), which us.
Probabilistic Verification of Storm Prediction Center Convective Outlooks

AbstractEight years’ worth of day 1 and 4.5 years’ worth of day 2–3 probabilistic convective outlooks from the Storm Prediction Center (SPC) are converted to probability grids spanning the continental United States (CONUS). These results are then evaluated using standard probabilistic forecast metrics including the Brier skill score and reliability diagrams. Forecasts are gridded in two different ways: one with a high-resolution grid and interpolation between probability contours and another on an 80-km-spaced grid without interpolation. Overall, the highest skill is found for severe wind forecasts and the lowest skill is observed for tornadoes; for significant severe criteria, the opposite discrepancy is observed, with highest forecast skill for significant tornadoes and approximately no overall forecast skill for significant severe winds. Highest climatology-relative skill is generally observed over the central and northern Great Plains and Midwest, with the lowest—and often negative—skill seen in the W.
Host–Microbiome Interactions: Tryptophan Metabolism and Aromatic Hydrocarbon Receptors after Traumatic Brain Injury

Traumatic brain injury refers to the damage caused to intracranial tissues by an external force acting on the head, leading to both immediate and prolonged harmful effects. Neuroinflammatory responses play a critical role in exacerbating the primary injury during the acute and chronic phases of TBI. Research has demonstrated that numerous neuroinflammatory responses are mediated through the “microbiota–gut–brain axis,” which signifies the functional connection between the gut microbiota and the brain. The aryl hydrocarbon receptor (AhR) plays a vital role in facilitating communication between the host and microbiota through recognizing specific ligands produced directly or indirectly by the microbiota. Tryptophan (trp), an indispensable amino acid in animals and humans, represents one of the key endogenous ligands for AhR. The metabolites of trp have significant effects on the functioning of the central nervous system (CNS) through activating AHR signalling, thereby establishing bidirectional communication between the gut microbiota and the brain. These interactions are mediated through immune, metabolic, and neural signalling mechanisms. In this review, we emphasize the co-metabolism of tryptophan in the gut microbiota and the signalling pathway mediated by AHR following TBI. Furthermore, we discuss the impact of these mechanisms on the underlying processes involved in traumatic brain injury, while also addressing potential future targets for intervention.
2D Modelling and energy analysis of entrapped air-pocket propagation and spring-like geysering in the drainage pipeline system

Transient (highly unsteady) air–water two-phase flows and spring-like geysers have been one of the critical concerns in drainage pipeline systems, which may cause or exacerbate drainage flooding problems and associated damage consequences. In this paper, the flow dynamics and energy evolution mechanism of the induced spring-like geysers are innovatively investigated through a two-phase full-2D numerical model developed in this study. After full validation by laboratory experimental tests conducted in this study, the proposed 2D model is systematically applied to simulate transient air–water flows in drainage pipelines. The results have shown acceptable accuracy of this full-2D model to capture the complex flow interactions between the air and water phases, and indicated that the velocity and pressure distribution patterns are highly relevant to the air–water interface deformation and energy exchange. The in-depth energy analysis demonstrates that the intermittent eruption of geysers could be attributed to the conservation and release of different energy forms during the transient air–water two-phase flow process. Besides, the numerical applications for the systems with different boundaries and initial conditions indicate that the different ventilation conditions and initially entrapped air volume may significantly affect the velocity distribution of the air phase, thereby playing an essential role to provide effective measures to mitigate unexpected geyser events and pressure oscillations in the system. The results and findings of this paper could provide insights to improve the theory and practice of transient air–water two-phase flows in drainage pipeline systems.
“Multiple Mode Procedures” of Ultra-Pulse Fractional CO2 Laser: A Novel Treatment Modality of Facial Atrophic Acne Scars

Background and aim: Fractional CO2 laser is therapeutic for acne atrophic scar, but its effect usually is limited after multiple sessions, with occasional adverse reactions. This study aimed to evaluate the efficacy and safety of a new modality combining ultra-pulse CO2 laser and fractional CO2 laser (multiple mode procedures [MMP]) in the treatment of acne atrophic scars. Method: From December 2017 to January 2023, a total of 103 patients with facial acne atrophic scars treated with MMP technique were retrospectively analyzed. MMP was performed for 1–4 sessions with an interval of approximately three months. Based on photographs taken before and after treatment, overall atrophic scar improvement was assessed according to the ECCA grading scale, the modified Manchester Scar Scale and the 4-point Global Assessment Scale (GAS). The safety was evaluated by the degree of pain during treatment and postoperative adverse reactions. Results: All the 103 patients received treatment and completed follow-up, with an average of two sessions. The mean ECCA score decreased from 162.7 to 93.1 with statistically significant difference (p < 0.001). The mean GAS score increased by an average of 2.3 ± 0.9. The GAS improvement more evident for “boxcar” atrophic scars (2.7 ± 0.8) than for “rolling” (2.3 ± 0.8) and “icepick” scars (1.7 ± 0.8) (p < 0.001). The average improvement scores for color, distortion and texture were 2.0 ± 0.9, 2.2 ± 0.9 and 2.3 ± 0.8, respectively. The mean pain score during treatment was 3.9 ± 0.8, and the mean duration of erythema was 30.7 ± 3.5 days. Only three patients developed hyperpigmentation at the treated site within a few months. Discussion: Ultra-pulse CO2 fractional laser MMP technique can effectively improve the condition of facial atrophic acne scars with limited adverse reactions.
Biosensing Platform for the Detection of Biomarkers for ALI/ARDS in Bronchoalveolar Lavage Fluid of LPS Mice Model

Acute respiratory distress syndrome (ARDS) is a worldwide health concern. The pathophysiological features of ALI/ARDS include a pulmonary immunological response. The development of a rapid and low-cost biosensing platform for the detection of ARDS is urgently needed. In this study, we report the development of a paper-based multiplexed sensing platform to detect human NE, PR3 and MMP-2 proteases. Through monitoring the three proteases in infected mice after the intra-nasal administration of LPS, we showed that these proteases played an essential role in ALI/ARDS. The paper-based sensor utilized a colorimetric detection approach based on the cleavage of peptide–magnetic nanoparticle conjugates, which led to a change in the gold nanoparticle-modified paper sensor. The multiplexing of human NE, PR3 and MMP-2 proteases was tested and compared after 30 min, 2 h, 4 h and 24 h of LPS administration. The multiplexing platform of the three analytes led to relatively marked peptide cleavage occurring only after 30 min and 24 h. The results demonstrated that MMP-2, PR3 and human NE can provide a promising biosensing platform for ALI/ARDS in infected mice at different stages. MMP-2 was detected at all stages (30 min–24 h); however, the detection of human NE and PR3 can be useful for early- (30 min) and late-stage (24 h) detection of ALI/ARDS. Further studies are necessary to apply these potential diagnostic biosensing platforms to detect ARDS in patients.
The Effect of Healthy Mental Lifestyle Package On Sleep Quality, Mental Health, and Lifestyle of Substance Users

Background: The aim of this study was to assess the effect of a training package based on the lived experience of substance abusers on sleep problems and mental health. Materials and Methods: The current study was performed on 70 subjects equally distributed into two groups of control and intervention, Data collection tools included the Pittsburgh Sleep Quality Index (PSQI), the General Health Questionnaire (GHQ), and the Basic Adlerian Scales for Interpersonal Success—Adult Form (BASIS-A) Inventory. Data analysis was administered using the independent t-test, paired t-test, and MANCOVA. Statistical significance was considered when the P value < 0.05. Results: A total of 70 subjects participated in this study; 7 (10.6%) were females and 59 (89.4%) were males, with a mean age of 36.29 ± 8.588 years. The total score of PSQI was 12.48 (±4.206) and 13.16 (±3.397) for control and intervention groups, respectively, and declined to 12.33 (±4.442) and 9.56 (±4.45) after the intervention. The intervention resulted in an improved score for scales of belonging, going along, taking charge, harshness, being liked by all, and striving for perfection. Whereas the total score of the GHQ is reduced for both groups, that in the intervention group showed a higher decrease, which was also statistically significant. Conclusion: The developed training package successfully improved participants’ sleep quality, mental health, and lifestyle.
Fourier-transform spatial modulation spectroscopy of single gold nanorods

Abstract Sensing the scattered fields of single metallic nanostructures is a crucial step towards the applications of isolated plasmonic antennas, such as for the sensing of single molecules or nanoparticles. In the past, both near- and far-field spectroscopy methods have been applied to monitor single plasmonic resonances. So far, however, these spectral-domain techniques do not yet provide the femtosecond time resolution that is needed to probe the dynamics of plasmonic fields in the time domain. Here, we introduce a time-domain technique that combines broadband Fourier-transform spectroscopy and spatial modulation spectroscopy (FT-SMS) to quantitatively measure the extinction spectra of the isolated gold nanorods with a nominal footprint of 41×10 nm2. Using a phase-stable pulse pair for excitation, the technique is capable of rejecting off-resonant stray fields and providing absolute measurements of the extinction cross section. Our results indicate that the method is well suited for measuring the optical response of strongly coupled hybrid systems with high signal-to-noise ratio. It may form the basis for new approaches towards time-domain spectroscopy of single nanoantennas with few-cycle time resolution.
Overview of the Genetic Causes of Hereditary Breast and Ovarian Cancer Syndrome in a Large French Patient Cohort

Simple Summary Hereditary Breast and Ovarian Cancer syndrome (HBOC) is an inherited trait that predisposes adults to an earlier onset of cancer than the general population. HBOC is an autosomal dominant condition caused by heterozygous mutations in one of the HBOC genes. Pathogenic variants in BRCA1 and BRCA2 are considered to be the most prevalent causes of HBOC, though mutations on other less common genes have also been described. In 2017, the French Genetic and Cancer Group recommended the screening of 13 genes in individuals with a strong suspicion of HBOC. Here, we report and discuss the results of a retrospective analysis of genetic data related to HBOC gene sequences in a large cohort of 4630 French cases. This work also demonstrated the importance of retesting BRCA1/2 negative cases, as well as the relevance of functional splicing tests in variant classification. Abstract The use of multigene panel testing for patients with a predisposition to Hereditary Breast and Ovarian Cancer syndrome (HBOC) is increasing as the identification of mutations is useful for diagnosis and disease management. Here, we conducted a retrospective analysis of BRCA1/2 and non-BRCA gene sequencing in 4630 French HBOC suspected patients. Patients were investigated using a germline cancer panel including the 13 genes defined by The French Genetic and Cancer Group (GGC)—Unicancer. In the patients analyzed, 528 pathogenic and likely pathogenic variants (P/LP) were identified, including BRCA1 (n = 203, 38%), BRCA2 (n = 198, 37%), PALB2 (n = 46, 9%), RAD51C (n = 36, 7%), TP53 (n = 16, 3%), and RAD51D (n = 13, 2%). In addition, 35 novel (P/LP) variants, according to our knowledge, were identified, and double mutations in two distinct genes were found in five patients. Interestingly, retesting a subset of BRCA1/2-negative individuals with an expanded panel produced clinically relevant results in 5% of cases. Additionally, combining in silico (splicing impact prediction tools) and in vitro analyses (RT-PCR and Sanger sequencing) highlighted the deleterious impact of four candidate variants on splicing and translation. Our results present an overview of pathogenic variations of HBOC genes in the southeast of France, emphasizing the clinical relevance of cDNA analysis and the importance of retesting BRCA-negative individuals with an expanded panel.
THE INFLUENCE OF SERVICE QUALITY AND CONSUMER TRUST TOWARDS CUSTOMER SATISFACTION ON SHOPEE IN MANADO

The rapid development of the digital economy in Indonesia has had a positive impact on the national economy, one of which is the growth of various online trading platforms or e-commerce. Shopee is an e-Commerce that serves interactive buying and selling between sellers and buyers online in the form of a mobile application to make it easier for users to carry out online shopping activities without having to open a website through a computer device. The purpose of this study was to the influence of service quality and customer trust towards customer satisfaction on Shopee in Manado. This study uses multiple linear regression. The population in this study is people who shop online through Shopee in Manado. The type of population used in this study is an unlimited population and for the sampling technique using purposive sampling. Keywords: service quality, consumer trust, customer satisfaction
Factors Associated with Survival in Wilms Tumor Patients

Introduction: Wilms tumor is the second most common abdominal tumor in the pediatric age group and accounts for more than 90% of renal tumors in pediatrics. Even though the described survival rate is greater than 90%, we found that it only reaches 70% among our patients. Therefore, we aim to evaluate which are the factors associated with these unfavorable results, in order to implement measures to improve the survival of our patients. Methods: An observational, cross-sectional study was conducted in two high-level care centers, which included a sample of 84 patients under 15 years of age, diagnosed with Wilms tumor. Results: Factors significantly associated with an increased likelihood of death were failure to complete the chemotherapy protocol (odds ratio [OR] = 34; 95% confidence interval [CI] = 3.7–312; P = 0.000) and tumor recurrence (OR = 35.7; 95% CI = 6.9–184; P = 0.000). Other minor factors with certain impact were bilateral presentation (OR = 4.1; 95% CI = 0.6–5.5; P = 0.147), surgical complications (OR = 3.2; 95% CI = 0.7–14.6; P = 0.136), lymph node involvement on CT scan (OR 2.4; 95% CI 0.7­–8.4; P = 0.139), and distant metastases (OR = 2.5; 95%CI = 0.7–9; P = 0.143). Discussion: The survival of our patients with Wilms tumor is lower than that reported in literature is associated with factors like failure to complete chemotherapy, recurrence, and the need for bilateral surgery.
Correlates of Undernutrition in Older People in Guadeloupe (French West Indies): Results from the KASADS Study

Abstract Objectives: This study aimed to determine the risk factors for undernutrition in community-dwelling older adults in Guadeloupe (Caribbean islands). Methods: We used data from the KArukera Study of Aging-Drugs Storage (KASADS), an observational cross-sectional study of community-dwelling older people living in Guadeloupe. The Mini Nutritional Assessment (MNA) was used to assess the risk of undernutrition. An MNA-short form (SF) score ≤11 defined the risk of undernutrition. Depression was assessed using the Center for Epidemiologic Studies Depression (CES-D) scale, cognitive function was assessed using the Mini Mental State Examination (MMSE), frailty was assessed using the Study of Osteoporotic Fractures index (SOF), and dependency was assessed using Lawton’s instrumental activities of daily living (IADL) scale. Bivariate and multivariate analyses were used to determine the correlates of undernutrition. Results: The study sample comprised 115 patients aged 65 years or older; 67.8% were women, and the mean age was 76 ± 7.8 years. The prevalence of undernutrition was 21.7% (95% CI = 15.2–30.1%). In our bivariate analysis, the risk of undernutrition was associated with MMSE score, IADL score, frailty, and CES-D score. We found no significant relation between nutrition risk and other variables, such as marital status, pain, or polypharmacy. In the multivariate analysis, the factors associated with the risk of undernutrition were MMSE score (Odd-Ratio (OR): 0.74 (0.58–0.97)) and CES-D score (OR: 1.13 (1.02–1.27)). Conclusions: Cognitive decline and the risk of depression were independently associated with the risk of undernutrition in community-dwelling older people in Guadeloupe. Although we cannot imply causality in this relation, the detection of these three key geriatric syndromes in community-dwelling elders is essential to prevent adverse health outcomes. Further studies are warranted to confirm these findings.
Absolute Photoionization Cross Section for Fe6+ to Fe10+ Ions in the Photon Energy Region of the 2p–3d Resonance Lines

Resonant single photoionization cross sections of Fen+ (n = 6 to 10) ions have been measured in absolute values using a merged-beams setup at the SOLEIL synchrotron radiation facility. Photon energies were between about 710 and 780 eV, covering the range of the 2p–3d transitions. The experimental cross sections are compared to calculations we performed using a multi-configuration Dirac–Fock code and the OPAS code dedicated to radiative opacity calculations. Comparisons are also done with the Chandra X-ray observatory NGC 3783 spectra and with the results of previously published calculations.
Scattering of SH wave by a semi-cylindrical salient near vertical interface in the bi-material half space

Abstract With the aid of the Green function method and image method, the problem of scattering of SH-wave by a semi-cylindrical salient near vertical interface in bi-material half-space is considered to obtain its steady state response. Firstly, by the means of the image method, Green function which is the essential solution of displacement field is constructed to satisfy the stress-free condition on the horizontal boundary in a right-angle space including a semi-cylindrical salient and bearing a harmonic out-of-plane line source force at any point on the vertical boundary. Secondly, the bi-material is separated into two parts along the vertical interface, then unknown anti-plane forces are applied on the vertical interface, and according to the continuity condition, the first kind of Fredholm integral equations is established to determine unknown anti-plane forces by “the conjunction method”, then the integral equations are reduced to the linear algebraic equations by effective truncation. Finally, the dynamic stress concentration factor (DSCF) around the edge of semi-cylindrical salient is calculated, and the influences of incident wave number, incident angle, effect of interface and different combination of material parameters, etc. on DSCF are discussed.