Miracle-dz/UniFAR-FTUs huggingface dataset:
TURISMO DE NEGÓCIOS: UM ESTUDO SOBRE A PERCEPÇÃO DE VALOR DOS SERVIÇOS HOTELEIROS NA ÓTICA DO TURISTA DE NEGÓCIOS

A finalidade desta pesquisa foi identificar os fatores que influenciam a percepção de valor para o turista de negócios em relação aos serviços hoteleiros. Buscou-se identificar a partir de três dimensões (Hotel, Apartamento e Funcionários) as variáveis principais que podem agregar valor ao serviço oferecido. Utilizou-se a metodologia quantitativa exploratória, sendo os dados coletados por meio de questionários com pessoas que no exercício de suas funções profissionais viajam regularmente, a amostra foi do tipo não probabilística e por acessibilidade sendo composta por 45 respondentes. Os resultados sugerem que os aspectos básicos em hotelaria, tais como segurança, cordialidade, localização, comunicação, silêncio e ducha são os mais valorizados pelos turistas de negócios. Alguns aspectos considerados como diferenciais pelas cadeias hoteleiras, tais como, banheira, fitness center, sala de reuniões apresentam pouca relevância para este tipo de hóspede. A pesquisa concentrou-se na identificação dos atributos sem sua análise qualitativa. O presente estudo adiciona a literatura sobre turismo de negócios. Em particular, contribui para compreender sob a ótica deste turista o que pode ser considerado um diferencial, e esclarece aos dirigentes para o direcionamento de suas políticas de gestão.
27th Annual Inter national Conference of the IEEE Engineering in Medicine and Biology Society

Only a small minority of mobile healthcare technologies that have been successful in pilot studies have subsequently been integrated into healthcare systems. Understanding the reasons behind this discrepancy is crucial if such technologies are to be adopted. We believe that the mismatch is due to a breakdown in the relation between technical soundness of the original mobile health (mHealth) device design, and integration into healthcare provision workflows. Quantitative workflow modelling provides an opportunity to test this hypothesis. In this paper we present our current progress in developing a clinical workflow model for mobile eye assessment in low-income settings. We test the model for determining the appropriateness of design parameters of a mHealth device within this workflow, by assessing their impact on the entire clinical workflow
Prevalence of neonatal septicaemia in a tertiary care hospital in Mandya, Karnataka, India

Background: Neonatal sepsis is defined as a clinical syndrome in an infant 28 days of life or younger, manifested by systemic signs of infection and isolation of a bacterial pathogen from the bloodstream. Neonatal sepsis is caused by Gram-positive and Gram-negative bacteria and candida. Microbial invasion of the bloodstream can have serious consequences such as shock, multi-organ failure, disseminated intravascular coagulation (DIC) and death. This study was conducted to know the prevalence of neonatal septicaemia. Methods: This retrospective observational study was conducted in the Department of Microbiology. The data was collected from the records of the Department for a period of one year (January 2014- December 2014). Results: Among 128 blood samples processed from clinically suspected neonatal septicaemic cases, 45 (35.1%) samples showed growth. Among 45 isolates, 22 were from early onset septicaemia (EOS) and 23 were from Late Onset Septicaemia (LOS). Among 45 culture positives, 32 (71.1%) were from males and 13(28.9%) were from females, thus showing a male preponderance. Klebsiella pneumoniae and Candida were the major isolates, 37.8% each. The antibiotic sensitivity showed that most of the Gram negative bacteria were highly resistant to the commonly used antibiotics like Ampicillin and Gentamicin. Gram positive bacteria showed 100% sensitivity to linezolid and Gram negative bacteria showed more than 90% sensitivity to imipenem. Conclusions: Development of sepsis in neonates is a medical emergency and generally the clinicians do not wait for microbiology report and start treatment empirically. If local microbiological databases are available with information regarding the commonly isolated organisms and their drug resistance patterns, it can help the clinicians in empirical therapy.
Anabolic–androgenic steroid use among Brazilian women: an exploratory investigation

Abstract The illicit use of anabolic–androgenic steroids (AAS) is a public health problem and the prevalence of use is increasing among different populations including women. We aimed to evaluate the use of AAS in a sample of Brazilian women and to develop a user profile in order to support the development of AAS education, prevention, and treatment programs. A self-administered, anonymous, close-ended questionnaire was completed by 361 female recreational resistance training participants (29.0 ± 8.1 years). Descriptive statistics were applied. The prevalence rate of lifetime AAS use was 13.3% and the average age of AAS users (n = 48) was 25.4 ± 4.6 years. The most frequently used AAS are Stanozolol (Winstrol) and Oxandrolone. Other substances used in association with AAS are primarily alcohol and diuretics. Friends, physicians, and physical education teachers were the most common sources for obtaining AAS. Several adverse effects were noted as follows: acne, menstrual irregularities, water retention, deepening of the voice, and clitoral enlargement. In summary, the primary reason for AAS use among the women was aesthetic; the AAS used were purchased primarily through friends and from pharmacies using medical prescriptions.
Therapeutic focus. The fluoroquinolones.

: The family of fluoroquinolones is an attractive group of bactericidal antibiotics with a wide range of activity against Gram-negative organisms and some Gram-positive bacteria. In addition to being highly bactericidal, these antibiotics are effective by mouth, side effects are few and bacterial resistance is minimal. These antibiotics have an assured place in the management of urinary tract infections, gonorrhoea, chlamydial infection, cystic fibrosis, typhoid fever, travellers' diarrhoea, biliary infection and as an alternative agent in respiratory infections. Nalidixic acid was the pioneer quinolone, but has now been succeeded by a whole new family of fluoroquinolones with greater bactericidal activity and a considerably wider antibacterial spectrum. Ciprofloxacin (Ciproxin, Bayer UK Ltd) is joined by norfloxacin (Noroxin, Merck, Sharpe & Dohme), perfloxacin, ofloxacin and enoxacin. This family of fluoroquinolones is attractive because effective treatment can be given by mouth, they are highly bactericidal, side effects are minimal and the spectrum of bacterial resistance seems to be small. There is also an obvious economic advantage over parenterally-administered drugs.
Expression and regulation of cytochrome P450 3As in human hepatocytes

Cytochrome P450 3A represents the most abundant P450 subfamily in human liver, and is responsible for the metabolism of >50 % of drugs on the market today. An area of intense study has been the xenobiotic regulation of CYP3A gene expression: this phenomenon potentially leads to altered pharmacokinetics/pharmacodynamics of substrates and adverse drug reactions. The use of hepatoma cell lines is common in drug metabolism studies; HuH7 is a human hepatoma cell line increasingly being used in both academia and the pharmaceutical industry. However, little is known regarding the expression profile of these cells. Recent data have made it increasingly clear that the gene expression profile of a cell system, and its alteration in response to external stimuli, is important in controlling expression of cytochrome P450 3As. Using quantitative PCR, transcript levels of CYP3A subfamily members and transcription factors implicated in their regulation were obtained in human adult and foetal RNA samples. These levels were then compared to those obtained from both primary human hepatocytes and HuH7 cells, showing that in general, primary or hepatoma cells show a distinct profile compared to either adult or foetal samples, with the major variables between the cell types being ratios of the transcription factors COUP-TF1 and RXRalpha to PXR. Whereas exposure to the CYP3A transcriptional activators PCN, rifampicin, dexamethasone and phenobarbital produced induction in primary human hepatocytes, no transcriptional activation was observed in HuH7 cells, suggesting that regulatory pathways were disrupted. Alterations in the gene expression profile, particularly the levels of COUP-TFl and PXR, and in the chromatin conformation surrounding the CYP3A gene cluster, were implicated to underlie this disruption. In conclusion, I have demonstrated that there are a number of levels of control of CYP3A gene expression, with both transcription factor expression levels and chromatin status having an impact on transcriptional activation of CYP3A genes in human hepatocytes.
The lived experience of orthodox Jewish nursing students

ABSTRACT Expanding cultural diversity in the United States creates social imperative requiring healthcare agencies to attract and retain nurses from diverse groups. The purpose of this research was to understand the lived experience of Orthodox Jewish nursing students. This study relied on phenomenological inquiry to illuminate their experience. Findings illustrate the students’ motivation to become a nurse and faith-based cultural values. Modesty reflected inner differences and appreciation of their devotion to personal/academic growth emerged. Findings can influence program development for minorities; inform curricula design and interventions; developing greater awareness and sensitivity of culturally diverse students to maximize their recruitment and retention.
Non-compliance to treatment among type 2diabetic men in Mosul: A case-control study

Context: Non-compliance to treatment among diabetic patients is a world-wide problem and its underlying risk factors can be the subject of many studies in different localities. Objective: To identify risk factors for non-compliance to treatment plan among type 2 diabetic men attending Al-Wafaa Center for diabetes in Mosul City. Methods: A case-control study design has been adopted. A special questionnaire form has been prepared and filled in by the investigator for each patient (case and control) through direct interview with patients. Results: Study results revealed a significant association between non-compliance and socioeconomic strata, duration of disease >10 years, number of tablets >2 daily, frequency of taking medication >2, poor patient satisfaction about health personnel, body mass index >30 and sedentary life style activities. On the other hand, an inverse association was found between non-compliance and urban place of residence, marriage, 1 0 and 2 0 school level of education, taking medical treatment without herbals and type A personality. Conclusion: The study concluded that health care professionals are in need to identify risky patients for non-compliance and recommends to use the counseling approach of communication before applying any individual patient management plan characteristics.
Coflex- Augmented Lumbar Microdecompression / Microlaminectomy(Comparative Pilot Study(

Objective: In this study, we selected patients older than 40 years of age with degenerative segmental stenosis & neurogenic claudication and analyzed whether the augmented lumbar microdecompression / microlaminectomy with the implantation of the coflex device is beneficial when compared with microdecompression / microlaminectomy surgery alone. Methods: Twenty five patients were treated with decompression augmented with the Coflex device, and 25 patients were treated with decompression alone during the same period. Clinical results were assessed using the pre- and postoperative visual analogue scale (VAS) and activities of daily living (ADL). Patients satisfaction was assessed using the validated outcome measurement, the Oswestry Disability Index Questionnaire (ODI). Radiologic results were assessed according to pre-and postoperative heights and segmental angles at the treated level. Results: The mean age of the patients in the Coflex device group was 46.9 years, and the in the decompression group was 50 years. The mean pre- and postoperative VAS scores were 8.8 and 3.4, respectively, in interspinous devices group and 7.2 and 2.2 in the decompression group. Both groups of patients showed significant improvement in their VAS and ADL scores in comparison with their preoperative scores. Radiologically, there were significant differences in disc heights and foraminal height between the two groups. Conclusions: The Coflex device was helpful in alleviating pain and improving ADL performance. It corrected segmental scoliosis and restricted extension. The addition of coflex device to the micro-decompression procedure, improves the clinical and radiological outcomes much, in properly-selected cases.
Infertility and womens reproductive health in Africa [editorial]

An estimated 20-30% of couples in Africa have considerable primary and secondary infertility. The increased incidence of infertility in Africa is evidently due to high prevalence of classic STDs complications connected with unsafe abortions and postpartum infections. There has though been very little concern with the implications of infertility for reproductive health in the continent. Several adverse effects of infertility on womens reproductive health in Africa are now being recognized. Infertility it is claimed is a major cause of marital disharmony. It also exposes women to social discrimination and physical violence. This can aggravate human rights abuses against African women leading to their socioeconomic disempowerment. Emerging evidence suggests an association between infertility and the HIV/AIDS epidemic in the continent. Reproductive health interventions and programs in Africa should target infertile women as a high-risk group. Finally it is recommended that specific intervention research should be conducted in order to evaluate both direct and indirect methods for preventing infertility in Africa. This research should include investigations of the cost-effectiveness of traditional and orthodox methods for treating infertility.
Men's Sexual and Relational Adaptations to Erectile Dysfunction After Prostate Cancer Treatment

ABSTRACT This study investigated how men adapt to erectile dysfunction and other sexual side-effects of prostate cancer treatment. The study recruited nonheterosexual and heterosexual men using an anonymous, international, online survey (N = 558). This article focuses on a qualitative analysis of answers (n = 348) to one open-ended question on sexual practices after treatment. Five themes emerged: (a) recovery of erectile function; (b) reframing sexual practices; (c) the importance of partners; (d) exploring anal sex; (e) the use of masturbation. The findings suggest that men should explore varied sexual options. Partners are also important in the overall recovery of men's sexual lives.
Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat

Background: Ulcerative colitis (UC) is a multi-factorial disease with unknown etiology and has many clinical manifestations. Objectives: The current study aimed to evaluate the effects of sesame oil (SO) and grapeseed oil (GSO) on acetic acid-induced UC in rats. Materials and Methods: Eighty male rats were divided into eight groups as health control (HC1), received normal saline; HC2, received SO; HC3, received GSO; negative control (NC), UC and normal saline; positive control (PC), UC and mesalamine; SO, UC and SO; GSO, UC and GSO, and SO + GSO. The daily weight changes, serum levels of oxidative stress markers and lipid profile plus colon macroscopic and microscopic histological changes were measured at the end of the seventh day. Results: Significant differences were detected between HC1 and PC on the 3 rd (P = 0.002), 4 (0.013) and 6 days (0.014) and between HC1 and NC on the 4 th day (0.027) in weight of rats. Use of GSO alone or in combination with SO decreased the extent of the changes both in macroscopic and microscopic indices and also at the inflammation level. The most significant decrease in the MDA level and the most obvious increase in the TAC belonged to the GSO group in comparison to the NC group. The lowest cholesterol (51.43 ± 5.62 mg/dL) and HDL levels (29.29 ± 6.24 mg/dL) were detected in response to SO consumption in comparison to NC group (P = 0.030 and P = 0.257, respectively). Conclusions: GSO in combination with SO may be considered as the treatment of choice for UC based on antioxidant and histopathological evaluations.
Parameter identifiability analysis for spatiotemporal models of cell invasion

We examine the practical identifiability of parameters in a spatiotemporal reaction-diffusion model of a scratch assay where we have access to a relatively large amount of quantitative experimental data. The experiment involves fluorescent cell cycle labels so that the cell cycle is tracked in real time. This provides spatial information about the position of individual cells as well as temporal information about the cell cycle phase of each cell. Cell cycle labelling is incorporated into the reaction-diffusion model by considering the total population to be composed of two interacting subpopulations. Practical identifiability is examined using a Bayesian Markov Chain Monte Carlo (MCMC) framework, confirming that the parameters are identifiable when we assume that the diffusivities of the two subpopulations are identical, but that the parameters are practically non-identifiable when we allow the diffusivities to be distinct. We also assess identifiability using a profile likelihood approach, and show that this provides similar results to MCMC with the advantage of being an order of magnitude faster to compute. Despite the profile likelihood being relatively underutilised in the mathematical biology literature, we suggest that it ought to be adopted as a screening tool to provide a rapid assessment of practical identifiability before more computationally cumbersome MCMC computations are attempted.
Metacarpophalangeal joint loads during bonobo locomotion: model predictions versus proxies

The analysis of internal trabecular and cortical bone has been an informative tool for drawing inferences about behaviour in extant and fossil primate taxa. Within the hand, metacarpal bone architecture has been shown to correlate well with primate locomotion; however, the extent of morphological differences across taxa is unexpectedly small given the variability in hand use. One explanation for this observation is that the activity-related differences in the joint loads acting on the bone are simply smaller than estimated based on commonly used proxies (i.e. external loading and joint posture), which neglect the influence of muscle forces. In this study, experimental data and a musculoskeletal finger model are used to test this hypothesis by comparing differences between climbing and knuckle-walking locomotion of captive bonobos (Pan paniscus) based on (i) joint load magnitude and direction predicted by the models and (ii) proxy estimations. The results showed that the activity-related differences in predicted joint loads are indeed much smaller than the proxies would suggest, with joint load magnitudes being almost identical between the two locomotor modes. Differences in joint load directions were smaller but still evident, indicating that joint load directions might be a more robust indicator of variation in hand use than joint load magnitudes. Overall, this study emphasizes the importance of including muscular forces in the interpretation of skeletal remains and promotes the use of musculoskeletal models for correct functional interpretations.
Research on stress release for the gob-side roadway using the roof-cutting technology with a chainsaw arm

The narrow pillar mining method is widely adopted for working faces in coal mines. However, in cases of an overlying hard roof, a suspended triangle roof plate or a cantilever will be formed near the goaf. At this point, the coal pillar extrusion and serious deformation will occur in the gob-side roadway. In order to mitigate the problem, the roof-cutting technology with a chainsaw arm and its equipment have been developed. In this paper, based on the analysis of deformation and failure characteristics of 2312 roadway, which is close to the goaf of 2311 working face in Tashan Coal, the roof-cutting technology with a chainsaw arm was chosen to be applied in 2311 roadway. Then, the roof-cutting process and the load acting on the coal pillar were discussed and analysed. A numerical model was established to analyse the stress releasing effects after roof cutting. Moreover, the roof-cutting height and the support parameters of the roadway were optimized through numerical analysis and the results manifested that the roof cutting was the most effective when the roof-cutting height was 6.4 m. After roof cutting, the vertical stresses within the coal pillars were lowered by about 25.0%. Finally, the roof-cutting experiment was carried out in the 2311 roadway in Tashan Coal Mine. The on-site roof-cutting depth was 6.4 m and the roof-cutting width was 42 mm guided by the numerical analysis. To verify the stress-relieving effects, the borehole stress meters were applied to monitor the peak advancing stresses of narrow pillars at various depths. The measured results indicated that the peak advancing stresses decreased by 22.8% on average, and therefore, roof cutting and stress releasing effects were achieved.
Mixed-species herding levels the landscape of fear

Prey anti-predator behaviours are influenced by perceived predation risk in a landscape and social information gleaned from herd mates regarding predation risk. It is well documented that high-quality social information about risk can come from heterospecific herd mates. Here, we integrate social information with the landscape of fear to quantify how these landscapes are modified by mixed-species herding. To do this, we investigated zebra vigilance in single- and mixed-species herds across different levels of predation risk (lion versus no lion), and assessed how they manage herd size and the competition–information trade-off associated with grouping behaviour. Overall, zebra performed higher vigilance in high-risk areas. However, mixed-species herding reduced vigilance levels. We estimate that zebra in single-species herds would have to feed for approximately 35 min more per day in low-risk areas and approximately 51 min more in high-risk areas to compensate for the cost of higher vigilance. Furthermore, zebra benefitted from the competition–information trade-off by increasing the number of heterospecifics while keeping the number of zebra in a herd constant. Ultimately, we show that mixed-species herding reduces the effects of predation risk, whereby zebra in mixed-species herds, under high predation risk, perform similar levels of vigilance compared with zebra in low-risk scenarios.