Miracle-dz/UniFAR-FTUs huggingface dataset:
Hard X-ray spectral variability of the brightest Seyfert AGN in the Swift/BAT sample

Aims. We analyse data from a 58 month long, continuous Swift/Burst Alert Telescope (BAT) series of observations of the five brightest Seyfert galaxies at hard X-rays, to study their flux and spectral variability in the 20‐100 keV energy band. The column density in these objects is less than 10 24 cm −2 , which implies that the Swift/BAT data allow us to study the “true” variability of the central source. Methods. We used 2-day binned light curves in the (20‐50) and (50‐100) keV bands to estimate their fractional variability amplitude, and the same band 20-day binned light curves to compute hardness ratios and construct “colour-flux” diagrams. We also considered a thermal Comptonization model, together with a reflection component with constant flux, and produced model “colour-flux” diagrams, assuming realistic variations in the model parameter values, which we then compared with the observed diagrams. Results. All objects show significant variations, with an amplitude that is similar to the AGN variability amplitude at energies below 10 keV. We found evidence of an anti-correlation between variability amplitude and black hole mass. The light curves in both bands are well-correlated with each other, with no significant delays on time scales as short as two days. We find that both NGC 4151 and NGC 2110 display no spectral variability, but that there is a significant anti-correlation between hardness ratios and source flux in NGC 4388 (and NGC 4945, IC 4329, to a lesser extent). This “softer when brighter” behaviour is similar to that observed at energies below 10 keV, and cannot be explained if the continuum varies only in flux; the intrinsic shape should also steepen with increasing flux. Conclusions. The detection of significant flux variations indicate that the central source in these objects is intrinsically variable on time scales as short as ∼1−2 days. The intrinsic slope of the continuum varies with the flux (at least in NGC 4388). The positive “spectral slope-flux” correlation can be explained if the temperature of the hot corona decreases with increasing flux. The lack of spectral variations in two objects (NGC 4151 and NGC 2110) might indicate that they are in a different “state”, as their accretion rate is less than 1% of the Eddington limit (significantly lower than the rate of the other three objects in the sample).
A long‐term follow‐up study of diabetic foot ulcer using micronized acellular dermal matrix

Treating a diabetic foot ulcer (DFU) extending to the tendon or bone can be a challenge for physicians. Recent studies have shown positive results of micronized acellular dermal matrix (ADM) treatment for treating DFU. However, studies on such ADM with a long‐term follow‐up are rare. Thus, the objective of this study was to retrospectively analyse patients treated with micronized ADM with a long‐term follow‐up to assess the effectiveness of the treatment and determine the recurrence rate. The rate of success of complete healing was 62.96% and the time of complete healing was 86.96 days in this study. The recurrence rate of DFUs was 41.17% in the overall group. However, it was only 23.52% in the micronized ADM group. The average duration of recurrence was 720.50 ± 505.12 days. The recurrence rate was 50% in weight bearing areas such as the plantar and heel. It was 12.5% in toes and non‐weight bearing areas. In conclusion, micronized ADM can be used to effectively treat DFUs that have invaded ligaments or bones. A close follow‐up of weight bearing area wounds will allow us to identify and treat recurrence early.
Searching for molecular outflows in hyperluminous infrared galaxies

We present constraints on the molecular outflows in a sample of five Hyper-Luminous Infrared Galaxies using Herschel observations of the OH doublet at 119 {\mu}m. We have detected the OH doublet in three cases: one purely in emission and two purely in absorption. The observed emission profile has a significant blueshifted wing suggesting the possibility of tracing an outflow. Out of the two absorption profiles, one seems to be consistent with the systemic velocity while the other clearly indicates the presence of a molecular outflow whose maximum velocity is about ~1500 km/s. Our analysis shows that this system is in general agreement with previous results on Ultra-luminous Infrared Galaxies and QSOs, whose outflow velocities do not seem to correlate with stellar masses or starburst luminosities (star formation rates). Instead the galaxy outflow likely arises from an embedded AGN.
Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability

Homologous recombination (HR) plays an essential role in the maintenance of genome stability by promoting the repair of cytotoxic DNA double strand breaks (DSBs). More recently, the HR pathway has emerged as a core component of the response to replication stress, in part by protecting stalled replication forks from nucleolytic degradation. In that regard, the mammalian RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) have been involved in both HR-mediated DNA repair and collapsed replication fork resolution. Still, it remains largely obscure how they participate in both processes, thereby maintaining genome stability and preventing cancer development. To gain better insight into their contribution in cellulo, we mapped the proximal interactome of the classical RAD51 paralogs using the BioID approach. Aside from identifying the well-established BCDX2 and CX3 sub-complexes, the spliceosome machinery emerged as an integral component of our proximal mapping, suggesting a crosstalk between this pathway and the RAD51 paralogs. Furthermore, we noticed that factors involved RNA metabolic pathways are significantly modulated within the BioID of the classical RAD51 paralogs upon exposure to hydroxyurea (HU), pointing towards a direct contribution of RNA processing during replication stress. Importantly, several members of these pathways have prognostic potential in breast cancer (BC), where their RNA expression correlates with poorer patient outcome. Collectively, this study uncovers novel functionally relevant partners of the different RAD51 paralogs in the maintenance of genome stability that could be used as biomarkers for the prognosis of BC.
Transport and the first passage time problem with application to cold atoms in optical traps

Measurements of spatial diffusion of cold atoms in optical lattices have revealed anomalous super-diffusion, which is controlled by the depth of the optical lattice. We use first passage time statistics to derive the diffusion front of the atoms. In particular, the distributions of areas swept under the first passage curve till its first arrival, and of areas under the Bessel excursion are shown to be powerful tools in the analysis of the atomic cloud. A rather general relation between first passage time statistics and diffusivity is discussed, showing that first passage time analysis is a useful tool in the calculation of transport coefficients. A brief introduction to the semi-classical description of Sisyphus cooling is provided which yields a rich phase diagram for the dynamics.
Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600–Mutant Low-Grade Glioma

PURPOSE BRAF V600 mutations occur in many childhood cancers, including approximately 20% of low-grade gliomas (LGGs). Here, we describe a phase I/II study establishing pediatric dosing and pharmacokinetics of trametinib with or without dabrafenib, as well as efficacy and safety in a disease-specific cohort with BRAF V600–mutant LGG; other cohorts will be reported elsewhere. METHODS This is a four-part, phase I/II study (ClinicalTrials.gov identifier: NCT02124772) in patients age < 18 years with relapsed/refractory malignancies: trametinib monotherapy dose finding (part A) and disease-specific expansion (part B), and dabrafenib + trametinib dose finding (part C) and disease-specific expansion (part D). The primary objective assessed in all patients in parts A and C was to determine pediatric dosing on the basis of steady-state pharmacokinetics. Disease-specific efficacy and safety (across parts A-D) were secondary objectives. RESULTS Overall, 139 patients received trametinib (n = 91) or dabrafenib + trametinib (n = 48). Trametinib dose-limiting toxicities in > 1 patient (part A) included mucosal inflammation (n = 3) and hyponatremia (n = 2). There were no dose-limiting toxicities with combination therapy (part C). The recommended phase II dose of trametinib, with or without dabrafenib, was 0.032 mg/kg once daily for patients age < 6 years and 0.025 mg/kg once daily for patients age ≥ 6 years; dabrafenib dosing in the combination was as previously identified for monotherapy. In 49 patients with BRAF V600–mutant glioma (LGG, n = 47) across all four study parts, independently assessed objective response rates were 15% (95% CI, 1.9 to 45.4) for monotherapy (n = 13) and 25% (95% CI, 12.1 to 42.2) for combination (n = 36). Adverse event–related treatment discontinuations were more common with monotherapy (54% v 22%). CONCLUSION The trial design provided efficient evaluation of pediatric dosing, safety, and efficacy of single-agent and combination targeted therapy. Age-based and weight-based dosing of trametinib with or without dabrafenib achieved target concentrations with manageable safety and demonstrated clinical efficacy and tolerability in BRAF V600–mutant LGG.
Inertial Frame Dragging in an Acoustic Analogue Spacetime

We report an incipient exploration of the Lense‐Thirring precession effect in a rotating acoustic analogue black hole spacetime. An exact formula is deduced for the precession frequency of a gyroscope due to inertial frame dragging, close to the ergosphere of a ‘Draining Bathtub’ acoustic spacetime which has been studied extensively for acoustic Hawking radiation of phonons and also for ‘superresonance’. The formula is verified by embedding the two dimensional spatial (acoustic) geometry into a three dimensional one where the similarity with standard Lense‐Thirring precession results within a strong gravity framework is well known. Prospects of experimental detection of this new ‘fixed‐metric’ effect in acoustic geometries, are briefly discussed.
NEAR-UV ABSORPTION IN VERY COOL DA WHITE DWARFS

The atmospheres of very cool, hydrogen-rich white dwarfs (WDs) (Teff < 6000 K) are challenging to model because of the increased complexity of the equation of state, chemical equilibrium, and opacity sources in a low-temperature, weakly ionized dense gas. In particular, many models that assume relatively simple models for the broadening of atomic levels and mostly ideal gas physics overestimate the flux in the blue part of their spectra. A solution to this problem that has met with some success is that additional opacity at short wavelengths comes for the extreme broadening of the Lyman α line of atomic H by collisions primarily with H2. For the purpose of validating this model more rigorously, we acquired Hubble Space Telescope STIS spectra of eight very cool WDs (five DA and three DC stars). Combined with their known parallaxes, BVRIJHK, and Spitzer IRAC photometry, we analyze their entire spectral energy distribution (from 0.24 to 9.3 μm) with a large grid of model atmospheres and synthetic spectra. We find that the red wing of the Lyman α line reproduces the rapidly decreasing near-UV flux of these very cool stars very well. We determine better constrained values of Teff and gravity as well as upper limits to the helium abundance in their atmospheres.
Cosmological constraints from a combination of galaxy clustering and lensing – I. Theoretical framework

We present a new method that simultaneously solves for cosmology and galaxy bias on non-linear scales. The method uses the halo model to analytically describe the (non-linear) matter distribution, and the conditional luminosity function (CLF) to specify the halo occupation statistics. For a given choice of cosmological parameters, this model can be used to predict the galaxy luminosity function, as well as the two-point correlation functions of galaxies, and the galaxy-galaxy lensing signal, both as a function of scale and luminosity. These observables have been reliably measured from the Sloan Digital Sky Survey. In this paper, the first in a series, we present the detailed, analytical model, which we test against mock galaxy redshift surveys constructed from high-resolution numerical N-body simulations. We demonstrate that our model, which includes scale dependence of the halo bias and a proper treatment of halo exclusion, reproduces the three-dimensional galaxy-galaxy correlation and the galaxy-matter cross-correlation (which can be projected to predict the observables) with an accuracy better than 10 (in most cases 5) per cent. Ignoring either of these effects, as is often done, results in systematic errors that easily exceed 40 per cent on scales of similar to 1 h(-1) Mpc, where the data are typically most accurate. Finally, since the projected correlation functions of galaxies are never obtained by integrating the redshift-space correlation function along the line of sight out to infinity, simply because the data only cover a finite volume, they are still affected by residual redshift-space distortions (RRSDs). Ignoring these, as done in numerous studies in the past, results in systematic errors that easily exceed 20 per cent on large scales (r(p) greater than or similar to 10 h(-1) Mpc). We show that it is fairly straightforward to correct for these RRSDs, to an accuracy better than similar to 2 per cent, using a mildly modified version of the linear Kaiser formalism.
Charge compensation in extremely large magnetoresistance materials LaSb and LaBi revealed by first-principles calculations

By the first-principles electronic structure calculations, we have systematically studied the electronic structures of recently discovered extremely large magnetoresistance (XMR) materials LaSb and LaBi. We find that both LaSb and LaBi are semimetals with the electron and hole carriers in balance. The calculated carrier densities on the order of ${10}^{20}\phantom{\rule{0.28em}{0ex}}{\mathrm{cm}}^{\ensuremath{-}3}$ are in good agreement with the experimental values, implying long mean-free time of carriers at low temperatures and thus high carrier mobilities. With a semiclassical two-band model, the charge compensation and high carrier mobilities naturally explain: (i) the XMR observed in LaSb and LaBi, (ii) the nonsaturating quadratic dependence of XMR on an external magnetic field, and (iii) the resistivity plateau in the turn-on temperature behavior at very low temperatures. The explanation of these features without resorting to the topological effect indicates that they should be the common characteristics of all electron-hole compensated semimetals.
Extra virgin olive oil improves HDL lipid fraction but not HDL-mediated cholesterol efflux capacity: a double-blind, randomised, controlled, cross-over study (OLIVAUS)

Abstract Olive oil (OO) polyphenols have been shown to improve HDL anti-atherogenic function, thus demonstrating beneficial effects against cardiovascular risk factors. The aim of the present study was to investigate the effect of extra virgin high polyphenol olive oil (HPOO) v. low polyphenol olive oil (LPOO) on the capacity of HDL to promote cholesterol efflux in healthy adults. In a double-blind, randomised cross-over trial, fifty participants (aged 38·5 (sd 13·9) years, 66 % females) were supplemented with a daily dose (60 ml) of HPOO (320 mg/kg polyphenols) or LPOO (86 mg/kg polyphenols) for 3 weeks. Following a 2-week washout period, participants crossed over to the alternate treatment. Serum HDL-cholesterol efflux capacity, circulating lipids (i.e. total cholesterol, TAG, HDL, LDL) and anthropometrics were measured at baseline and follow-up. No significant between-group differences were observed. Furthermore, no significant changes in HDL-cholesterol efflux were found within either the LPOO and HPOO treatment arms; mean changes were 0·54 % (95 % CI (0·29, 1·37)) and 0·10 % (95 % CI (0·74, 0·94)), respectively. Serum HDL increased significantly after LPOO and HPOO intake by 0·13 mmol/l (95 % CI (0·04, 0·22)) and 0·10 mmol/l (95 % CI (0·02, 0·19)), respectively. A small but significant increase in LDL of 0·14 mmol/l (95 % CI (0·001, 0·28)) was observed following the HPOO intervention. Our results suggest that additional research is warranted to further understand the effect of OO with different phenolic content on mechanisms of cholesterol efflux via different pathways in multi-ethnic populations with diverse diets.
Proton structure at the LHC

A determination of Parton Distribution Functions (PDFs) from a global fit to a dataset including measurements from the LHC has been performed. The determinations have been carried out according to the NNPDF methodology, leading to a fit minimising parametrisation bias and with an accurate account of PDF uncertainty. In this thesis the importance of QCD measurements at the LHC to PDF extraction are discussed, and we summarise some of the technical difficulties in their inclusion into PDF fits. A number of methods are presented that permit the efficient inclusion of these observables into PDF determinations. Firstly a Bayesian reweighting procedure taking advantage of the Monte Carlo representation of PDF uncertainties in NNPDF sets is discussed, which is demonstrated by a study of the impact of early W production asymmetry measurements from ATLAS, CMS and LHCb upon an earlier PDF set. A package for the fast computation of observables in an automated NLO framework is presented, providing an interface between Monte Carlo event generators and NLO interpolation tools. Finally, a method of combining PDF evolution with interpolating codes for hadronic observable computation is described. This method largely overcomes the computational difficulties in performing fast perturbative QCD predictions for collider observables. The method has been applied to the determination of PDFs from a global dataset including vector boson production data from LHCb, ATLAS and CMS along with inclusive jet data from ATLAS. Finally, the method of closure testing is introduced, and the method is applied to the study of the NNPDF methodology. A number of improvements are found in the minimisation and stopping procedures, which are adopted for the development of the next NNPDF release, NNPDF3.0.
RHAPSODY. II. SUBHALO PROPERTIES AND THE IMPACT OF TIDAL STRIPPING FROM A STATISTICAL SAMPLE OF CLUSTER-SIZE HALOS

We discuss the properties of subhalos in cluster-size halos, using a high-resolution statistical sample: the Rhapsody simulations introduced in Wu et al. We demonstrate that the criteria applied to select subhalos have significant impact on the inferred properties of the sample, including the scatter in the number of subhalos, the correlation between the subhalo number and formation time, and the shape of subhalos' spatial distribution and velocity structure. We find that the number of subhalos, when selected using the peak maximum circular velocity in their histories (a property expected to be closely related to the galaxy luminosity), is uncorrelated with the formation time of the main halo. This is in contrast to the previously reported correlation from studies where subhalos are selected by the current maximum circular velocity; we show that this difference is a result of the tidal stripping of the subhalos. We also find that the dominance of the main halo and the subhalo mass fraction are strongly correlated with halo concentration and formation history. These correlations are important to take into account when interpreting results from cluster samples selected with different criteria. Our sample also includes a fossil cluster, which is presented separately and placed in the context of the rest of the sample.
Best Practice Recommendations for the Safe use of Lung Ultrasound

Abstract The safety of ultrasound is of particular importance when examining the lungs, due to specific bioeffects occurring at the alveolar air-tissue interface. Lung is significantly more sensitive than solid tissue to mechanical stress. The causal biological effects due to the total reflection of sound waves have also not been investigated comprehensively. On the other hand, the clinical benefit of lung ultrasound is outstanding. It has gained considerable importance during the pandemic, showing comparable diagnostic value with other radiological imaging modalities. Therefore, based on currently available literature, this work aims to determine possible effects caused by ultrasound on the lung parenchyma and evaluate existing recommendations for acoustic output power limits when performing lung sonography. This work recommends a stepwise approach to obtain clinically relevant images while ensuring lung ultrasound safety. A special focus was set on the safety of new ultrasound modalities, which had not yet been introduced at the time of previous recommendations. Finally, necessary research and training steps are recommended in order to close knowledge gaps in the field of lung ultrasound safety in the future. These recommendations for practice were prepared by ECMUS, the safety committee of the EFSUMB, with participation of international experts in the field of lung sonography and ultrasound bioeffects.
AN AO-ASSISTED VARIABILITY STUDY OF FOUR GLOBULAR CLUSTERS

The image-subtraction technique applied to study variable stars in globular clusters represented a leap in the number of new detections, with the drawback that many of these new light curves could not be transformed to magnitudes due to severe crowding. In this paper, we present observations of four Galactic globular clusters, M 2 (NGC 7089), M 10 (NGC 6254), M 80 (NGC 6093), and NGC 1261, taken with the ground-layer adaptive optics module at the SOAR Telescope, SAM. We show that the higher image quality provided by SAM allows for the calibration of the light curves of the great majority of the variables near the cores of these clusters as well as the detection of new variables, even in clusters where image-subtraction searches were already conducted. We report the discovery of 15 new variables in M 2 (12 RR Lyrae stars and 3 SX Phe stars), 12 new variables in M 10 (11 SX Phe and 1 long-period variable), and 1 new W UMa-type variable in NGC 1261. No new detections are found in M 80, but previous uncertain detections are confirmed and the corresponding light curves are calibrated into magnitudes. Additionally, based on the number of detected variables and new Hubble Space Telescope/UVIS photometry, we revisit a previous suggestion that M 80 may be the globular cluster with the richest population of blue stragglers in our Galaxy.