Miracle-dz/UniFAR-FTUs huggingface dataset:
Sustainability of Sustainable Real Property Development

The paper investigates commercial buildings users' perception of the benefits of green buildings and how this perception influences their decision to occupy and/or invest in them. A survey of 400 commercial real estate users in Singapore reveals that they are aware of, and appreciate the benefits of green buildings. However, they are not willing to occupy and/or invest in green buildings as they are concerned with monetary returns. Price, reliability, and effectiveness of green features, as well as apathy towards environmental issues, are impeding the sustainability of sustainable commercial real estate in Singapore. Notwithstanding, since it was found that cost saving and higher property value benefits statistically influence respondents' willingness to invest in, or occupy green buildings, turning the sustainability advocacy into realistic economic advocacy could ensure sustainability of sustainable real estate development.
Effectiveness of behavioural interventions to reduce household energy demand: a scoping review

This paper provides a scoping review of behavioural interventions that target household energy demand. We evaluate 584 empirical papers that test the effectiveness of a behavioural intervention to change behaviour associated with household energy demand. The most studied behavioural tools are providing timely feedback and reminders and making information intuitive and easy to access, followed by (in order) communicating a norm, reframing consequences, making behaviour observable, obtaining a commitment, setting proper defaults, and transitions and habit disruption. The most studied demand-side behaviour is electricity use. There is high heterogeneity in effect sizes. We classified the target behaviours of each study as avoid, shift, or improve behaviours and find that avoid behaviours (in particular, reducing electricity usage) are the predominant focus of researchers. The effectiveness of interventions differs across avoid, shift, and improve responses and by the behavioural tool. Specifically, shifting behaviours are less effectively motivated than avoiding behaviours by using an information intervention but more effectively by using a norm intervention. We review the literature to provide further information about which behavioural tools are most effective for specific contexts. The effectiveness of most behavioural tools are augmented when they are used in the right combination with other tools. We recommend that researchers focus future work on high impact behaviours and the evaluation of synergistic combinations of behavioural interventions.
Diclofenac: A Nonsteroidal Anti-Inflammatory Drug Inducing Cancer Cell Death by Inhibiting Microtubule Polymerization and Autophagy Flux

Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used to treat inflammatory diseases induces cellular toxicity by increasing the production of reactive oxygen species (ROS) and impairing autophagic flux. In this study, we investigated whether diclofenac induces cancer cell death and the mechanism by which diclofenac causes cell death. We observed that diclofenac induces mitotic arrest with a half-maximal effective concentration of 170 μM and cell death with a half-maximal lethal dose of 200 µM during 18-h incubation in HeLa cells. Cellular microtubule imaging and in vitro tubulin polymerization assays demonstrated that treatment with diclofenac elicits microtubule destabilization. Autophagy relies on microtubule-mediated transport and the fusion of autophagic vesicles. We observed that diclofenac inhibits both phagophore movement, an early step of autophagy, and the fusion of autophagosomes and lysosomes, a late step of autophagy. Diclofenac also induces the fragmentation of mitochondria and the Golgi during cell death. We found that diclofenac induces cell death further in combination with 5-fuorouracil, a DNA replication inhibitor than in single treatment in cancer cells. Pancreatic cancer cells, which have high basal autophagy, are particularly sensitive to cell death by diclofenac. Our study suggests that microtubule destabilization by diclofenac induces cancer cell death via compromised spindle assembly checkpoints and increased ROS through impaired autophagy flux. Diclofenac may be a candidate therapeutic drug in certain type of cancers by inhibiting microtubule-mediated cellular events in combination with clinically utilized nucleoside metabolic inhibitors, including 5-fluorouracil, to block cancer cell proliferation.
Assessing the Impact of TQM Factors on Employee Satisfaction in Health Centers in the Kingdom of Bahrain

Employee satisfaction is one of the Total Quality Management (TQM) principles as indicated by some previous gurus and researchers. The definition of employee satisfaction is not consensus among researchers, as every investigator or scholar defined it according to their perspective. On the other hand, TQM is a viable approach to improving employee satisfaction. The aim of this study is to assess the impact of TQM factors on employee satisfaction in health centers (HC) of the Ministry of Health (MOH). Arising from the several implementing TQM factors, this study identified four factors; top management commitment; human resources; structure; and culture, which have significant correlation and influencing on employee satisfaction or dissatisfaction. An empirical design is employed both for quantitative and qualitative approaches. The main instrument used in this study is the questionnaire and semi-structured interviews which are used to support the interpretation of the current questionnaire results. A survey conducted with a sample of 203 employees from five HCs and 20 employees who participated in a semi-structured interview. This study shows that the employees of the HCs are moderately satisfied with their jobs. The implications and results of this study will assist the top management of HC and policy makers in the MOH to give more attention to employee satisfaction in parallel with patients’ satisfaction to improve the quality services.
Precision Nephrology in Patients with Diabetes and Chronic Kidney Disease

Diabetes is the leading cause of kidney failure and specifically, diabetic kidney disease (DKD) occurs in up to 30% of all diabetic patients. Kidney disease attributed to diabetes is a major contributor to the global burden of the disease in terms of clinical and socio-economic impact, not only because of the risk of progression to End-Stage Kidney Disease (ESKD), but also because of the associated increase in cardiovascular (CV) risk. Despite the introduction of novel treatments that allow us to reduce the risk of future outcomes, a striking residual cardiorenal risk has been reported. This risk is explained by both the heterogeneity of DKD and the individual variability in response to nephroprotective treatments. Strategies that have been proposed to improve DKD patient care are to develop novel biomarkers that classify with greater accuracy patients with respect to their future risk (prognostic) and biomarkers that are able to predict the response to nephroprotective treatment (predictive). In this review, we summarize the principal prognostic biomarkers of type 1 and type 2 diabetes and the novel markers that help clinicians to individualize treatments and the basis of the characteristics that predict an optimal response.
Human Cell Organelles in SARS-CoV-2 Infection: An Up-to-Date Overview

Since the end of 2019, the whole world has been struggling with the life-threatening pandemic amongst all age groups and geographic areas caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). The Coronavirus Disease 2019 (COVID-19) pandemic, which has led to more than 468 million cases and over 6 million deaths reported worldwide (as of 20 March 2022), is one of the greatest threats to human health in history. Meanwhile, the lack of specific and irresistible treatment modalities provoked concentrated efforts in scientists around the world. Various mechanisms of cell entry and cellular dysfunction were initially proclaimed. Especially, mitochondria and cell membrane are crucial for the course of infection. The SARS-CoV-2 invasion depends on angiotensin converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), and cluster of differentiation 147 (CD147), expressed on host cells. Moreover, in this narrative review, we aim to discuss other cell organelles targeted by SARS-CoV-2. Lastly, we briefly summarize the studies on various drugs.
Revision of the new Australasian orb-weaving spider genus Salsa (Araneae, Araneidae)

﻿Abstract A new Australasian genus in the orb-weaving spider family Araneidae Clerck, 1757 is described to include seven species: Salsafuliginata (L. Koch, 1871) comb. nov. (type species; = Epeirarubicundula Keyserling, 1887) syn. nov.) (Australia, introduced to New Zealand); S.brisbanae (L. Koch, 1867) comb. nov. (Australia); S.canalae (Berland, 1924) comb. nov. (New Caledonia); S.nenebasp. nov. (Papua New Guinea); S.recherchensis (Main, 1954) comb. nov. (Australia); S.ruedasp. nov. (Australia); and S.tartarasp. nov. (Australia; Lord Howe Island endemic). Salsagen. nov. belongs to the Australasian informal backobourkiine clade and differs from other genera of this clade by a distinct abdominal shape (single posterior abdominal tubercle) and ventral colouration (pale lateral spindle-shaped bands), male pedipalp morphology (C-shaped median apophysis that has teeth-like tubercles inside the basal arch) and the shape of the female epigyne scape (partially translucent and generally shorter than the epigyne plate). Based mainly on male pedipalp morphology within the backobourkiines, Salsagen. nov. has closest morphological affinities with Acroaspis Karsch, 1878 and Socca Framenau, Castanheira & Vink, 2022.
Polyphenols and Maillard Reaction Products in Dried Prunus spinosa Fruits: Quality Aspects and Contribution to Anti-Inflammatory and Antioxidant Activity in Human Immune Cells Ex Vivo

Dried Prunus spinosa fruits (sloes) are folk phytotherapeutics applied to treat chronic inflammatory disorders. However, their pharmacological potential, activity vectors, and drying-related changes in bioactive components remain unexplored. Therefore, the present research aimed to evaluate the anti-inflammatory and antioxidant effects of dried sloes in ex vivo models of human neutrophils and peripheral blood mononuclear cells (PMBCs) and establish their main active components. It was revealed that the fruit extracts significantly and dose-dependently inhibited the respiratory burst, downregulated the production of elastase (ELA-2) and TNF-α, and upregulated the IL-10 secretion by immune cells under pro-inflammatory and pro-oxidant stimulation. The slightly reduced IL-6 and IL-8 secretion was also observed. The structural identification of active compounds, including 45 phenolics and three Maillard reaction products (MRPs) which were formed during drying, was performed by an integrated approach combining LC-MS/MS, preparative HPLC isolation, and NMR studies. The cellular tests of four isolated model compounds (chlorogenic acid, quercetin, procyanidin B2, and 5-hydroxymethylfurfural), supported by statistical correlation studies, revealed a significant polyphenolic contribution and a slight impact of MRPs on the extracts’ effects. Moreover, a substantial synergy was observed for phenolic acids, flavonoids, condensed proanthocyanidins, and MPRs. These results might support the phytotherapeutic use of dried P. spinosa fruits to relieve inflammation and establish the quality control procedure for the extracts prepared thereof.
A Decade of Trauma-Informed Care: An Organizational Case Study

ABSTRACT There is optimism that the effects of childhood adversity can be mitigated through trauma-informed care (TIC) practices in school settings. This study investigated a nonprofit, therapeutic school’s experience with implementing and sustaining TIC. At both the organizational and individual levels, factors exist that complicate the application of TIC principles. This case study utilized a qualitative approach to better understand staff’s conceptualization of TIC, their attitudes concerning TIC, and their experiences using TIC practices. After a decade of TIC within the organization, the study found that staff have maintained overall favorable attitudes toward TIC, assimilated TIC principles into their beliefs about students, and view student aberrant behaviors through a TIC lens. Conversely, TIC failed to serve as a protective factor for staff due to an insufficient response from larger systems. Finally, the study showed that the lack of attention to historical traumas and systemic racism has the potential to compel staff to diverge from TIC practices. This research adds to the literature as it amplified the voices of staff to reveal the benefits and challenges of TIC.
Study of some blood indicators for non-infected with COVID-19 virus and those vaccinated with Pfizer, AstraZeneca and Sinopharm in Babil Governorate

The study included determining the extent of the effect of common vaccines for the Corona virus (COVID-19). Based on some blood tests of people not previously infected with the virus. From vaccinated and not vaccinated with Corona virus (COVID-19) vaccines, and of both sexes, a total number of 280 people. 70 samples of Pfizer vaccine, 70 Sinopharm, and 70 AstraZeneca. In addition to 70 samples for the control group for ages between (18-70) years, during the period from October 2021 to the end of April 2022. The highest value of blood count readings (WBC) was recorded for those vaccinated with AstraZeneca, which was (7.8), and the highest value was recorded The (RBC) for those vaccinated with Pfizer was [5.4], while the highest value for (Hb) was recorded for those vaccinated with Pfizer and it was (15.3). As for (PCV), the highest percentage of it was in the people vaccinated with AstraZeneca and Sinofam (43.8 and 43.0), and the highest percentage of (PLT) was for those vaccinated with Pfizer and Sinopharma (269.0 and 270.6), respectively.
Omicron Infection Evokes Cross-Protection against SARS-CoV-2 Variants in Vaccinees

Due to the rapid global spread of the Omicron (B.1.1.529) variant, efforts to scale up COVID-19 booster vaccination have been improved, especially in light of the increasing evidence of reduced neutralizing antibody (NT Ab) over time in vaccinated subjects. In this study, neutralizing antibody responses against the Wild-Type, Delta, and Omicron strains were evaluated among vaccinees, both infected with Omicron or uninfected, and non-vaccinated subjects infected with Omicron. The aim of the study was to compare the cross-protective humoral response to the variant strains induced by vaccination and/or Omicron infection. The results showed a significant difference in the neutralizing antibody response between the vaccinees and the Omicron-infected vaccinated subjects against the three tested strains (p < 0.001), confirming the booster effect of the Omicron infection in the vaccinees. By contrast, Omicron infection only did not enhance the antibody response to the other variants, indicating a lack of cross-protection. These results suggest the importance of updating the current formulation of the SARS-CoV-2 vaccine to protect people against the Omicron subvariants. A specific Omicron vaccine, administered as a booster for the previously adopted mRNA vaccines, may protect against a wider range of SARS-CoV-2 variants. However, it is unlikely that the Omicron vaccine alone would be able to protect non-vaccinated subjects against other circulating variants.
Performance evaluation of cassava starch-zinc nanocomposite film for tomatoes packaging

Biodegradable nanocomposite films are novel materials for food packaging because of their potential to extend the shelf life of food. In this research, the performance of cassava starch-zincnanocomposite film was evaluated for tomatoes packaging. The films were developed by casting the solutions of 24 g cassava starch, 0-2% (w/w) zinc nanoparticles and 55% (w/w) glycerol in plastic mould of 12 mm depth. The permeability of the films, due to water and oxygen, was investigated at 27°C and 65% relative humidity while the mechanical properties were determined by nanoindentation technique. The average thickness of the dried nanocomposite films was found to be 17±0.13 μm. The performances of films for tomatoes packaging was evaluated in comparison with low density polyethylene (LDPE; 10 μm) at the temperature and period ranges of 10-27°C and 0-9 days, respectively. The quality and microbial attributes of the packaged tomatoes, including ascorbic acid, β-carotene and total coliform were analysed at an interval of 3 days. The results revealed that the water vapour permeability increased while the oxygen permeability decreased with the nanoparticles (P<0.05). The hardness, creep, elastic and plastic works, which determined the plasticity index of the film, decreased generally with the nanoparticles. The films containing 1 and 2% of the nanoparticles suppressed the growth of microorganisms and retained the quality of tomatoes than the LDPE at 27°C and day-9 of packaging (P<0.05). The results implied that the film could effectively be used for tomatoes packaging due to their lower oxygen permeability, hardness, elastic and plastic works.
Mobility for teacher students or teacher students for mobility? Unravelling policy discourses on international student mobility in the context of teacher education

Forming part of the efforts to internationalise European higher education, international student mobility has become a key activity strongly supported and promoted by policymakers. In particular, the mobility of teacher students has become a more prominent issue over the past decades. However, to this date there is a lack of research focussing on this specific aspect of higher education mobility policies. Drawing on the analytical framework of discursive institutionalism, this article critically explores policy discourses on teacher student mobility as they emerge in a range of historical and contemporary European and Norwegian policy texts. Subsequently, it discusses how such discourses presuppose the function of teacher education and future teachers in the political agendas on internationalisation and mobility. The study finds that mobility in the context of teacher education is legitimated and promoted with discourses of harmonisation, professionalisation and instrumentalisation, and argues that these discourses are ambiguous and obscure the purpose of both the activity of mobility itself, as well as teacher education and what it educates for, with potential implications for how mobility policies can be realised. In doing so, the article contributes to a critical discussion about the drivers behind contemporary policies for internationalisation and mobility in higher education.
Does a Graf Type-I Hip Justify the Discontinuation of Pavlik Harness Treatment in Patients with Developmental Dislocation of the Hip?

Background: To analyze the clinical data of patients aged < 6 months with developmental dislocation of the hip (DDH) treated with Pavlik Harness (PH) in order to identify the best time to terminate PH treatment. Method: Fifty-four patients (47 females, 7 males; 63 hips) met the inclusion criteria and were included in the study; there were 33 (61.1%) left, 12 (22.2%) right and 9 (16.7%) bilateral DDH. The mean age at diagnosis was 11.8 ± 5.9 weeks (range, 1.4–25.5). All patients underwent fulltime PH treatment for about three months. At completion of PH treatment, patients were then divided into Group A, including patients with clinically stable hip joint and Graf type-I hip on ultrasound (US), and Group B, including patients with clinically stable hip joint and well-reduced hip on anterior-posterior (AP) radiographs without acetabular dysplasia. Six months after completion of PH treatment, the presence/absence of residual acetabular dysplasia (RAD) was evaluated on AP pelvis radiographs. The t-test and chi-square test were used to compare the differences in age, gender, side, Graf classification and RAD rate between the two groups of patients. Results: At completion of PH treatment, 45 hips were in Group A and 18 in Group B. There were no significant differences in age, gender, side, preoperative alpha angle and Graf classification between the two groups. Six months after discontinuation of PH, the AI in Group A (27.1° ± 6.8°) was significantly higher than that in Group B (21.9° ± 3.5°; p = 0.001); moreover 23 hips (51.1%) in Group A developed RAD compared to one hip in Group B (5.6%; p = 0.001). Among Group A patients, those with RAD were significantly older (13.7 ± 4.9 weeks) than those with normal hips (7.6 ± 3.8 weeks; p < 0.001); the incidence of RAD was significantly lower in patients with Graf type-II D hips (22.2%) than in patients with Graf type-III (70%) and type-IV hips (71.4%; p = 0.006). However, logistic regression analysis identified age as the only risk factor for RAD. All 24 hips with RAD (24/63, 38.1%) were treated with abduction braces. At final follow-up, AI in Group A (20.5° ± 3.3°) was not significantly different from that in Group B (21.9° ± 3.3°; p = 0.132). At the last follow-up visit, five hips (11.1%) in Group A still had RAD, compared to none in Group B (p = 0.31). Conclusions: In patients with DDH treated by PH, Graf type-I on US is not an absolute timing to terminate PH treatment. In addition, patients ≥ 13 weeks had a high risk of RAD despite PH treatment as 51.1% of infants developed RAD during follow up. Follow-up radiographs should be requested in all patients achieving Graf type-I hips at completion of PH treatment.
Ultra-Violet Protection and Anti-Static Characteristics with Heat Release/Shielding of Al2O3/ATO/TiO2-Imbedded Multi-Functional Fabrics

This study examined the ultra-violet (UV) protection and anti-static characteristics with heat release by far-infrared (FIR) emissivity of Al2O3/Antimony Tin Oxide (ATO)/TiO2-imbedded PET fabrics according to the weight (wt.) percentage of the Al2O3/ATO particles imbedded in the yarns. The fabric with lower Al2O3/ATO wt. percentage had more effective heat release than that of the fabric with higher percentage due to the heat shielding property of the ATO particles. The fabric with lower Al2O3/ATO wt. percentage (higher TiO2) exhibited higher UV protection factor (UPF) than that of the fabric with higher percentage, which suggested that the UV protection characteristic of TiO2 particles imbedded in the yarn was superior to that of the Al2O3/ATO particles. The anti-static property of the higher wt. % of ATO-imbedded fabric was superior to that of the lower wt. % of ATO-imbedded fabric, which means that ATO inorganic particles provide superior anti-static property to the Al2O3 and TiO2 particles. On the other hand, Al2O3/ATO particles imbedded in the yarns imparted an uncomfortable tactile hand feel and wear fitness to the fabrics.