Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychometric properties and gender invariance of the 8-item emotion regulation questionnaire (ERQ-8) among Chinese university students

Background To assess emotion regulation strategies in a clear and direct manner, Emotion Regulation Questionnaire (ERQ) was developed based on the process model of emotion regulation. ERQ primarily assesses an individual’s propensity for reappraisal (a cognitive change in the individual’s psychological state in specific situations) and expressive suppression (a regulatory response where an individual alters their emotional response after the onset of an emotional reaction). Recent studies have suggested that the abbreviated 8-item version of the ERQ exhibits comparable model fit to the original version. The present study aimed to explore the psychometric properties and assess cross-gender invariance of the ERQ-8 in Chinese university students. Methods University students from Jiangsu Province participated in this study. Participants completed self-report surveys assessing emotion regulation strategies. It was conducted from May 2022 to July 2022. The study employed confirmatory factor analysis (CFA) to assess the two-factor model of ERQ-8 and measurement invariance across male and female samples. Results The mean age of 1534 participants was 19.83 years (SD = 1.54), and the majority were female (70.4%). The initial ERQ-10 model with ten items demonstrated good fit for all indicators, CFI (Comparative Fit index) = 0.967, TLI (Tucker-Lewis Index) = 0.957, RMSEA (Root Mean Square Error of Approximation) = 0.043, SRMR (Standardised Root Mean Square Residual) = 0.029. However, to assess the fit of the previously proposed ERQ-8 model, two items (Q1 and Q3) were excluded. The fit of the ERQ-8 model was further improved (CFI = 0.989, TLI = 0.984, RMSEA = 0.029, SRMR = 0.021). All item loadings exceeded or were equal to 0.573. Internal consistency analysis based on the ERQ-8 model revealed Cronbach’s alpha values of 0.840 for reappraisal and 0.745 for suppression, and corresponding composite reliability (CR) values of 0.846 and 0.747, respectively. Test-retest reliability, assessed using the intraclass correlation coefficient (ICC) (95% CI) within a one-week interval, ranged from 0.537 to 0.679. The correlation coefficient between the two factors was 0.084, significantly below 0.85, which suggested a low correlation between the two factors. The results of the invariance analysis across gender demonstrated that the values of ΔCFI and ΔTLI were both below 0.01. It was supported the gender invariance of the ERQ-8 among university students. Conclusion The eight-item ERQ demonstrated validity and reliability in evaluating emotion regulation strategies, and measurement invariance was observed across gender among university students. The ERQ-8 may prove to be a practical and cost-effective tool, particularly in time-constrained situations.
World Journal of Transplantation

BACKGROUND Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a global pandemic that is associated with a high risk of morbidity and mortality among recipients of solid organ transplantation. In the course of acute SARS-CoV-2 infection, various laboratory markers have been identified as predictors for high risk of mortality. AIM To risk stratify
Role of lateral soft tissues release in percutaneous hallux valgus correction: A medium term retrospective study

BACKGROUND In the field of minimally invasive surgery (MIS) for the treatment of hallux valgus (HV), different techniques have begun to emerge in the literature concerning the distal osteotomy of the first metatarsal bone, the synthesis or not of the metatarsal head, the possible association with lateral soft tissues release (LSTR) and osteotomy of the base of the first phalanx. AIM To evaluate the role of LSTR on percutaneous HV correction, evaluating functional and radiographical results. METHODS From January 2012 to May 2016 a total of 396 patients with mild to moderate symptomatic HV treated with the MIS technique were included in this retrospective study. The technique provides no internal fixation (WOS). Patients were divided into the LSTR group and no LSTR group (LSTR N). This surgical procedure (LSTR) was reserved for insufficient HV angle (HVA) correction during fluoroscopic control. Patients were evaluated at each follow-up by two other authors after appropriate training by senior authors (first practitioners). Clinical evaluation was performed before surgery, 6 mo after surgery, and 48 mo follow-up. American Orthopaedic Foot and Ankle Society (AOFAS) and visual analog scale (VAS) score was used to evaluate pain and function, and complications were recorded. In addition, the incidence of relapses and the degree of joint range of motion (ROM) with the association with the LSTR (capsule, adductor tendon, phalanx-sesamoid ligament, and the deep transverse metatarsal ligament) were evaluated. Radiological parameters included HVA and intermetatarsal angle (IMA). Patient satisfaction was assessed. Student t-test and Fisher exact test were used to assess statistical analysis. RESULTS From our study it is clear that no differences in term of HVA, VAS, IMA correction, rate of complications, and AOFAS score were found between groups, while a significant improvement of the same variables was found in each group between pre and postoperative values. A significant improvement in ROM at 6 mo (P = 0.018) and 48 mo (P = 0.02) of follow-up was found in LSTR N group. Complications were rare in both groups. CONCLUSION LSTR procedure on percutaneous HV correction seems to increase postoperative joint stiffness with a comparable incidence of relapse and a low incidence of complications.
Antimicrobial susceptibility, resistance determinants and molecular epidemiology of Neisseria gonorrhoeae in Ireland

High-level resistance to and treatment failures with ceftriaxone and azithromycin, the first line agents for treatment of gonorrhoea are reported and antimicrobial-resistant N. gonorrhoeae is now an urgent public health threat. This study investigated rates of resistance to extended-spectrum cephalosporins (ESCs), azithromycin and other agents among gonococci in Ireland, resistance mechanisms and molecular epidemiology of the most resistant subset of isolates. Six-hundred and nine isolates from 4 different tertiary referral hospitals in Ireland were recovered for susceptibility testing against extended-spectrum cephalosprorins, azithromycin, ertapenem, ciprofloxacin, gemifloxacin, penicillin, tetracycline, spectinomycin, gentamicin and fosfomycin by gradient MIC strip. Forty-three isolates were selected for whole-genome sequencing based on elevated MICs, in particular to extended-spectrum cephalosporins and azithromycin. Sequencing libraries of N. gonorrhoeae genomic DNA were generated using the NexteraXTTM library preparation kit according to manufacturer? s instructions and sequenced on an Illumina MiSeq instrument. The NG-STAR database, pubMLST tool and ARG-ANNOT database were employed for data analysis. Seven high-level azithromycin resistant (HLAzi-R) isolates were identified, while no resistance to ceftriaxone was found. All isolates were susceptible to spectinomycin. 98.2%, 33% and 9.7% of isolates were non-susceptible to penicillin, ciprofloxacin and tetracycline, respectively. MIC90 for ertapenem, gemifloxacin, gentamicin and fosfomycin were 0.032 mg/L, 2 mg/L, 8 mg/L and 32 mg/L, respectively. Mosaic penA alleles XXXIV, X and non-mosaic XIII were associated with elevated ESC MICs. L421P mutation in ponA, G120K plus A121N/D/G alterations in penB (encoding PorB), H105Y alteration in mtrR and A deletions in the mtrR promoter were also associated with reduced susceptibility to ESCs. A2059G and C2611T mutations in 23s rRNA alleles were associated with HLAzi-R and gonococci with azithromycin MICs of 4-32 mg/L, respectively. The 43 isolates belonged to 31 NG-MAST STs and most prevalent MLST STs included ST1580, ST9396 and ST1901. All HLAzi-R isolates belonged to MLST ST1580, among which some clonal clustering was observed. When these isolates were compared to HLAzi-R isolates from a UK outbreak, analysed at a whole-genome sequence level, they differed significantly. This is the largest genomic study of Irish N. gonorrhoeae performed to date. Ceftriaxone remains a suitable empiric agent for treatment of gonorrhoea in Ireland. A number of potential alternative agents were identified. There was good correlation between previously described genetic mutations and phenotypic susceptibility categories for ESCs and azithromycin and N. gonorrhoeae. This work highlights the advantages and potential of whole-genome sequencing to be applied at scale in the surveillance of antibiotic resistant strains of N. gonorrhoeae, both locally and internationally.
Effect Analysis of Wearing an Lumbar Exoskeleton on Coordinated Activities of the Low Back Muscles Using sEMG Topographic Maps

Lumbar exoskeleton has potential to assist in lumbar movements and thereby prevent impairment of back muscles. However, due to limitations of evaluation tools, the effect of lumbar exoskeletons on coordinated activities of back muscles is seldom investigated. This study used the surface electromyography (sEMG) topographic map based on multi-channel electrodes from low back muscles to analyze the effects. Thirteen subjects conducted two tasks, namely lifting and holding a 20kg-weight box. For each task, three different trials, not wearing exoskeleton (NoExo), wearing exoskeleton but power-off (OffExo), and wearing exoskeleton and power-on (OnExo), were randomly conducted. Root-mean-square (RMS) and median-frequency (MDF) topographic maps of the recorded sEMG were constructed. Three parameters, average pixel values, distribution of center of gravity (CoG), and entropy, were extracted from the maps to assess the muscle coordinated activities. In the lifting task, results showed the average pixel values of RMS maps for the NoExo trial were lower than those for the OffExo trial (<inline-formula> <tex-math notation="LaTeX">$\text{p} < 0.05$ </tex-math></inline-formula>) but the same as those for the OnExo trial (<inline-formula> <tex-math notation="LaTeX">$\text{p}>$ </tex-math></inline-formula>0.05). The distribution of CoG showed a significant difference between NoExo and OnExo trials (<inline-formula> <tex-math notation="LaTeX">$\text{p} < 0.05$ </tex-math></inline-formula>). In the holding task, RMS and MDF maps’ average pixel values showed significant differences between NoExo and OnExo trials (<inline-formula> <tex-math notation="LaTeX">$\text{p} < 0.05$ </tex-math></inline-formula>). These findings suggest that active lumbar exoskeletons can reduce the load on low back muscles in the static holding task rather than in the dynamic lifting task. This proves sEMG topographic maps offer a new way to evaluate such effects, thereby helping improve the design of lumbar exoskeleton systems.
The Self-reference Effect Can Modulate Language Syntactic Processing Even Without Explicit Awareness: An Electroencephalography Study

Abstract Although it is well established that self-related information can rapidly capture our attention and bias cognitive functioning, whether this self-bias can affect language processing remains largely unknown. In addition, there is an ongoing debate as to the functional independence of language processes, notably regarding the syntactic domain. Hence, this study investigated the influence of self-related content on syntactic speech processing. Participants listened to sentences that could contain morphosyntactic anomalies while the masked face identity (self, friend, or unknown faces) was presented for 16 msec preceding the critical word. The language-related ERP components (left anterior negativity [LAN] and P600) appeared for all identity conditions. However, the largest LAN effect followed by a reduced P600 effect was observed for self-faces, whereas a larger LAN with no reduction of the P600 was found for friend faces compared with unknown faces. These data suggest that both early and late syntactic processes can be modulated by self-related content. In addition, alpha power was more suppressed over the left inferior frontal gyrus only when self-faces appeared before the critical word. This may reflect higher semantic demands concomitant to early syntactic operations (around 150–550 msec). Our data also provide further evidence of self-specific response, as reflected by the N250 component. Collectively, our results suggest that identity-related information is rapidly decoded from facial stimuli and may impact core linguistic processes, supporting an interactive view of syntactic processing. This study provides evidence that the self-reference effect can be extended to syntactic processing.
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus

Significance The emergence of naturally drug-resistant opportunistic pathogens, such as Mycobacterium abscessus (Mab), presents a growing and deeply concerning public health threat due to few effective therapeutic options and a limited drug development pipeline. This research addresses this critical gap by introducing a unique series of N-ethylene aminomethyl spectinomycin (eAmSPC) analogs that show impressive activity against Mab. We have successfully unraveled the intricate mechanism by which the eAmSPC analogs overcome TetV-mediated efflux, thus reactivating the activity of spectinomycin against Mab. These mechanistic insights are enhanced by extensive developmental endeavors, showcasing the promising potential of this series as treatments against Mab infections.
Evaluation of soluble phosphorus loading from manure-applied fields under various spreading strategies

ABSTRACT: A simple model was developed and applied to a dairy farm in the New York City (NYC) water supply watershed to evaluate the effectiveness of various manure spreading strategies for reducing non-point source, soluble phosphorus (SP) pollution. Phosphorus from manure-spread fields is recognized as one of the important non-point source pollutants in the region and there is acute interest in developing economically viable water quality management practices. The NYC watershed initiative, i.e. the Watershed Agriculture Program (WAP), mandated that water quality management practices would be scientifically justifiable based on the best information available (Walter and Walter, 1999). Thus, this project was carried-out to evaluate manure-handling strategies based on the currently available information. The model for predicting SP loading to perennial streams via surface runoff was developed by combining a mechanistic hydrological model with an empirical relationship for SP concentration in runoff. This study showed that, in the short term, because of soil P accumulation associated with a history of dairy farming, the maximum possible reduction in SP loading to perennial streams is about 50%. Exporting all manure from the NYC watersheds attains this. Utilizing the concept of hydrologically sensitive areas (Walter et al. 2000), this study suggests possible SP loading reductions of 25% with all manure remaining on-farm. This study supports and emphasizes the finding by Walter et al. (2000) that the timing and location of manure spreading strongly influences SP transport.
Minimally invasive ureteroplasty with lingual mucosal graft for complex ureteral stricture: analysis of surgical and patient-reported outcomes

ABSTRACT Objective: To evaluate objective treatment efficacy and safety, and subjective patient-reported outcomes in patients with complex ureteral strictures (US) undergoing minimally invasive lingual mucosal graft ureteroplasty (LMGU). Materials and Methods: We prospectively enrolled patients underwent robotic or laparoscopic LMGU between May 2020 and July 2022. Clinical success was defined as symptom-free and no radiographic evidence of re-obstruction. Patient-reported outcomes, including health-related quality of life (HRQoL), mental health status and oral health-related quality of life (OHRQoL), were longitudinally evaluated before surgery, 6 and 12 months postoperatively. Results: Overall, 41 consecutive patients were included. All procedures were performed successfully with 32 patients in robotic approach and 9 in laparoscopic. Forty (97.56%) patients achieved clinical success during the median follow-up of 29 (range 15-41) months. Although patients with complex US experienced poor baseline HRQoL, there was a remarkable improvement following LMGU. Specifically, the 6-month and 12-month postoperative scores were significantly improved compared to the baseline (p < 0.05) in most domains. Twenty-eight (68.3%) and 31 (75.6%) patients had anxiety and depression symptoms before surgery, respectively. However, no significant decrease in the incidence of these symptoms was observed postoperatively. Moreover, there was no significant deterioration of OHRQoL at 6 months and 12 months postoperatively when compared to the baseline. Conclusions: LMGU is a safe and efficient procedure for complex ureteral reconstruction that significantly improves patient-reported HRQoL without compromising OHRQoL. Assessing patients’ quality of life enables us to monitor postoperative recovery and progress, which should be considered as one of the criteria for surgical success.
Human Visual Cortex and Deep Convolutional Neural Network Care Deeply about Object Background

Abstract Deep convolutional neural networks (DCNNs) are able to partially predict brain activity during object categorization tasks, but factors contributing to this predictive power are not fully understood. Our study aimed to investigate the factors contributing to the predictive power of DCNNs in object categorization tasks. We compared the activity of four DCNN architectures with EEG recordings obtained from 62 human participants during an object categorization task. Previous physiological studies on object categorization have highlighted the importance of figure-ground segregation—the ability to distinguish objects from their backgrounds. Therefore, we investigated whether figure-ground segregation could explain the predictive power of DCNNs. Using a stimulus set consisting of identical target objects embedded in different backgrounds, we examined the influence of object background versus object category within both EEG and DCNN activity. Crucially, the recombination of naturalistic objects and experimentally controlled backgrounds creates a challenging and naturalistic task, while retaining experimental control. Our results showed that early EEG activity (< 100 msec) and early DCNN layers represent object background rather than object category. We also found that the ability of DCNNs to predict EEG activity is primarily influenced by how both systems process object backgrounds, rather than object categories. We demonstrated the role of figure-ground segregation as a potential prerequisite for recognition of object features, by contrasting the activations of trained and untrained (i.e., random weights) DCNNs. These findings suggest that both human visual cortex and DCNNs prioritize the segregation of object backgrounds and target objects to perform object categorization. Altogether, our study provides new insights into the mechanisms underlying object categorization as we demonstrated that both human visual cortex and DCNNs care deeply about object background.
ADHD in Adults: Does Age at Diagnosis Matter?

OBJECTIVE To provide additional information about clinical features associated with adult ADHD in patients diagnosed in childhood compared to those first diagnosed in adulthood. METHOD We stratified a sample of adults with ADHD into patients diagnosed in childhood versus adulthood and compared demographic and clinical characteristics. RESULTS We found similar clinical features in adults diagnosed in childhood and adults diagnosed in adulthood. Among those diagnosed in adulthood, 95% reported symptom onset in youth. Our results do not support the hypothesis that ADHD diagnosed in adulthood is due to misinterpreting symptoms of other disorders as ADHD. They also suggest incorporating behavioral signs of executive dysfunction into diagnostic criteria for ADHD in adults may increase diagnostic sensitivity. CONCLUSION These results support the validity of ADHD diagnoses in adulthood, as these adults show similar clinical profiles to those diagnosed in youth. Our results also suggest that if adult-onset ADHD exists, it is rare.
Impacts on functional and oncological outcomes of Robotic-assisted Radical Prostatectomy 10 years after the US Preventive Service Taskforce recommendations against PSA screening

ABSTRACT Objective: In the following years after the United States Preventive Service Task Force (USPSTF) recommendation against prostate cancer screening with PSA in 2012, several authors worldwide described an increase in higher grades and aggressive prostate tumors. In this scenario, we aim to evaluate the potential impacts of USPSTF recommendations on the functional and oncological outcomes in patients undergoing robotic-assisted radical prostatectomy (RARP) in a referral center. Material and Methods: We included 11396 patients who underwent RARP between 2008 and 2021. Each patient had at least a 12-month follow-up. The cohort was divided into two groups based on an inflection point in the outcomes at the end of 2012 and the beginning of 2013. The inflection point period was detected by Bayesian regression with multiple change points and regression with unknown breakpoints. We reported continuous variables as median and interquartile range (IQR) and categorical variables as absolute and relative percent frequencies. Results: Group 1 had 4760 patients, and Group 2 had 6636 patients, with a median follow-up of 109 and 38 months, respectively. In the final pathology, Group 2 had 9.5% increase in tumor volume, 24% increase on Gleason ≥ 4+3 (ISUP 3), and 18% increase on ≥ pT3. This translated to a 6% increase in positive surgical margins and 24% reduction in full nerve sparing in response to the worsening pathology. There was a significant decline in post-operative outcomes in Group 2, including a 12-month continence reduction of 9%, reduction in potency by 27%, and reduction of trifecta by 22%. Conclusions: The increasing number of high-risk patients has led to worse functional and oncologic outcomes. The initial rapid rise in PSM was leveled by the move towards more partial nerve sparing. Among some historical changes in prostate cancer diagnosis and management in the period of our study, the USPSTF recommendation coincided with worse outcomes of prostate cancer treatment in a population who could benefit from PSA screening at the appropriate time.