Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between atypical antipsychotics drugs, QT interval prolongation, and torsades de pointes: implications for clinical use

ABSTRACT Introduction: Increased mortality has been observed in patients with mental health disorders. Specifically, exposure to antipsychotic medications conveys a greater than 2 fold risk of sudden death, thought to be mediated through effects on QT prolongation and risk of torsades de pointes. Areas covered: We review the association between antipsychotic drugs and sudden cardiac death, the physiologic basis for these associations, assessment of patients at risk, and strategies to minimize risk of sudden cardiac death. Expert opinion: Despite the prevalence of antipsychotic medication use for many decades, there remain considerable challenges in reducing the associated risk of sudden cardiac death. A structured algorithm that incorporates patient clinical factors and antipsychotic drug factors may improve risk assessment and reduce the risk of adverse cardiac events. Future advancements in genetics and artificial intelligence may allow for enhanced risk stratification and predicting response (efficacy and adverse effects) to therapy.
Diagnosing coeliac disease in the elderly: a United Kingdom cohort study

Aim: To assess the outcomes for an elderly population with coeliac disease and to compare with younger adults with CD. Background: Coeliac disease in the elderly has been underdiagnosed due to the heterogeneity of presentation as well as lack of physicians’ awareness of CD in this population. However, the benefits of diagnosing CD in the elderly may be contentious. Methods: Newly diagnosed CD patients were prospectively recruited from the Coeliac Specialist Clinic at the Royal Hallamshire Hospital, Sheffield, between 2008 and 2017. All patients had villous atrophy (VA) on biopsy with positive coeliac serology. Additionally, the patients were retrospectively recruited from 1990 to 2008 to determine the trend in elderly CD diagnostic frequency over time. Results: A total of 1605 patients with CD were recruited (n=644 prospectively, n=961 retrospectively). Of these, 208 patients (13.0%) were diagnosed over the age of 65 years between 1990 and 2017. The proportion of elderly CD diagnoses increased from 0% in 1990-1991 to 18.7% in 2016-2017 (p<0.001). Younger patients more commonly presented with fatigue (p<0.001) and gastrointestinal symptoms including diarrhoea (p=0.005), abdominal pain (p=0.019), and IBS-type symptoms (p=0.008), while older people more frequently presented with B12 deficiency (p=0.037). Conclusion: The prevalence of CD in the elderly has significantly increased over the last two decades, but elderly patients tend to present with fewer symptoms. Further research is required to determine whether a strict gluten-free diet in these patients is a necessity or a burden.
Genetic variability of influenza A virus in pigs at weaning in Midwestern United States swine farms.

Suckling piglets play an important role at maintaining influenza A virus (IAV) infections in breeding herds and disseminating them to other farms at weaning. However, the role they play at weaning to support and promote genetic variability of IAV is not fully understood. The objective here was to evaluate the genetic diversity of IAV in pigs at weaning in farms located in the Midwestern USA. Nasal swabs (n = 9,090) collected from piglets in breed-to-wean farms (n = 52) over a six-month period across seasons were evaluated for the presence of IAV. Nasal swabs (n = 391) from 23 IAV-positive farms were whole-genome sequenced. Multiple lineages of HA (n = 7) and NA (n = 3) were identified in 96% (22/23) and 61% (237/391) of the investigated farms and individual piglets, respectively. Co-circulation of multiple types of functional HA and NA was identified in most (83%) farms. Whole IAV genomes were completed for 126 individual piglet samples and 25 distinct and 23 mixed genotypes were identified, highlighting significant genetic variability of IAV in piglets. Co-circulation of IAV in the farms and co-infection of individual piglets at weaning was observed at multiple time points over the investigation period and appears to be common in the investigated farms. Statistically significant genetic variability was estimated within and between farms by AMOVA, and varying levels of diversity between farms were detected using the Shannon-Weiner Index. Results reported here demonstrate previously unreported levels of molecular complexity and genetic variability among IAV at the farm and piglet levels at weaning. Movement of such piglets infected at weaning may result in emergence of new strains and maintenance of endemic IAV infection in the US swine herds. Results presented here highlight the need for developing and implementing novel, effective strategies to prevent or control the introduction and transmission of IAV within and between farms in the country.
How important are phase 1 interventions for complex interpersonal trauma? A pilot randomised control trial of a group psychoeducational intervention.

Although psychoeducational interventions are recommended as phase 1 interventions for complex trauma there is limited evidence on their efficacy. This pilot randomised control trial (RCT) investigated the efficacy of a pure psychoeducational intervention for complex trauma. A brief 10 session intervention was delivered to n=44 female prisoners in a compressed format to accommodate short sentence lengths and was compared to usual care (n=42). Results from an intent-to-treat (ITT) analysis indicated that there were no statistically significant differences between the two arms across the three assessment time points (including one month post intervention) for the main outcomes (Behavioural Assessment Checklist-Revised, β= 4.60 [95%CI, -1.60 to 10.88], p= .148; PTSD Checklist, β= -1.47 [95%CI, -4.30 to 1.36], p= .303). Post hoc Reliable Change analyses suggested twice the number of AD participants made progress in addressing PTSD symptoms compared to usual care (30.3% vs 17.6%, OR 2.03 [95%CI, .64 to 6.43]). Whilst further work in this area is required, initial results, overall, suggest that psychoeducational group based treatment modalities achieve only small effect sizes in comparison to usual care.
Evaluating the Effect of the rs2229238 and the rs4845625 Interleukin 6 Receptor Gene Polymorphisms on Body Mass Index and the Risk of Type 2 Diabetes in an Iranian Study Population

Background: Type 2 diabetes (T2D) is an inflammatory disease that may cause inflammatory responses if it is not controlled and may also lead to clinical manifestations such as retinopathy, nephropathy, and neuropathy. IL6 is an important proinflammatory cytokine that controls the influence of systemic inflammation on acute phase responses. To work effectively, IL6 must bind with its IL6 receptor (IL6R). Objectives: The current study aimed to investigate the possible associations between two IL6R polymorphisms, namely, rs2229238 and rs4845625, and their susceptibility to T2D. Methods: This case-control study was done on 250 T2D patients and 250 healthy individuals. The polymorphisms were genotyped using an amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Results: Our findings showed that either the rs2229238 or the rs4845625 variant was associated with T2D in a sample of the Iranian population. The rs2229238 C/T polymorphism showed a strong significant difference in the CT genotype (OR = 0.38, %95 CI = 0.23 0.65, P = 0.000), as well as in the TT genotype (OR = 0.18, %95 CI = 0.05 0.63, P = 0.007) as a protective factor against T2D in both the patient and the control group. In contrast, the rs4845625 C/T polymorphism showed a significant difference in the CT genotype (OR = 1.92, %95 CI = 1.15 3.23, P = 0.031) and in the TT genotype (OR = 1.59, %95 CI = 1.08 2.38, P = 0.021) as a risk factor for T2D in both the patient and the control group. An investigation of the alleles relating to these single nucleotide polymorphisms (SNPs) showed that the T allele of rs2229238 (OR = 0.34, %95 CI = 0.22 0.52, P = 0.000) and the T allele of rs4845625 (OR = 1.43, % 95 CI = 1.11 1.84, P = 0.006) were significantly different between the subject and control groups, and that these two polymorphisms play a protective and a risk factor role in T2D, respectively. A statistical analysis of the demographic and clinical data showed no significant association between the CC genotype and the CT + TT genotype in the patient group, with the exception of body mass index (BMI) (P = 0.023) in the rs4845625 polymorphism and HDL (P = 0.025) in the rs2229238 SNP. Conclusions: We identified a strong association between the T allele of IL6R gene polymorphisms (rs2229238, rs4845625) and the risk of T2D in a protective role and as a risk factor, respectively. We also found different BMI and HDL values between the patient group and the control group, respectively. Further studies on various ethnicities are necessary to verify our findings.
Elevated Expression of miR-629 Predicts a Poor Prognosis and Promotes Cell Proliferation, Migration, and Invasion of Osteosarcoma

Purpose Osteosarcoma (OS) is an invasive bone tumor that primarily affects children and adolescents. MicroRNA-629 (miR-629) acts as an oncogene involved in the development of various cancers. This study aims to reveal the clinical significance and biological function of miR-629 in OS. Patients and Methods The levels of miR-629 expression in tissues and cells were detected through quantitative real-time polymerase chain reaction (qRT-PCR). Chi-square test was used to evaluate the relationship between miR-621 expression and clinical parameters in patients with OS. Survival analysis was performed by the Kaplan–Meier method. Cox regression analysis of the effect of miR-629 expression on the prognosis of OS patients. CCK-8 and Transwell experiments were used to demonstrate the effect of miR-629 on OS cell function. Results Compared with the controls, miR-629 levels were significantly elevated in patients with OS (P < 0.001), Furthermore, miR-629 upregulation showed significantly associated with clinical stage (P = 0.011), distant metastasis (P = 0.003) and poor survival (log rank test, P = 0.013) in OS patients. miR-629 might be a potential prognostic biomarker for OS (HR = 2.890, 95% CI = 1.126–7.416, P = 0.027). Cell function experiments proved that the high expression of miR-629 promoted cell proliferation, migration, and invasion of OS. Conclusion All experimental results demonstrated that miR-629 as an oncogene promotes the tumor cell growth, migration and invasion of OS, and miR-629 may act as a novel prognostic biomarker and therapeutic target for patients with this malignant tumor.
The response of soil Olsen-P to the P budgets of three typical cropland soil types under long-term fertilization

The Olsen phosphorus (Olsen-P) concentration of soil is generally a good indicator for estimating the bioavailability of P and environmental risk in soils. To maintain soil Olsen-P at adequate levels for crop growth and environmental sustainability, the relationship between soil Olsen-P and the P budget (the P input minus the output) as well as the variations of soil Olsen-P and P budget were investigated from three long-term (22 years) experiments in China. Five treatments were selected: (1) unfertilized control (CK); (2) nitrogen and potassium (NK); (3) nitrogen, phosphorous, and potassium (NPK); (4) nitrogen, phosphorous, potassium and straw; (5) nitrogen, phosphorous, potassium and manure. The results showed that without P fertilizers (CK, NK), there was a soil P deficit of 75–640 kg ha-1, and the lowest P deficit (mean of CK and NK) was in Eutric Cambisol. Soil Olsen-P decreased by 0.11–0.39 mg kg-1 year-1 in the order of Luvic Phaeozems > Eutric Cambisol > Calcaric Cambisol. Soil Olsen-P and the P deficit had a significantly (P<0.01) positive linear relationship. For every 100 kg of P ha–1 of deficit, soil Olsen-P decreased by 0.44–9.19 mg kg–1 in the order of Eutric Cambisol > Luvic Phaeozems > Calcaric Cambisol. Under the P fertilizer treatments (NPK, NPKS, and NPKM), soil Olsen-P showed an obvious surplus (except the NPK and NPKS in Luvic Phaeozems) of 122–2190 kg ha-1, and the largest P surplus was found under the NPKM treatment at each site. The relation between soil Olsen-P and the experimental years could be simulated using quadratic equation of one unknown in Calcaric Cambisol for the lower P input after 14 years of fertilization. And soil Olsen-P increased by 1.30–7.69 mg kg-1 year-1 in the order of Luvic Phaeozems > Eutric Cambisol. The relation between soil Olsen-P and the P surplus could be simulated by a simple linear equation except under NPK and NPKS in Luvic Phaeozems. With 100 kg ha-1 P surplus, soil Olsen-P increased by 3.24–7.27 mg kg-1 in the order of Calcaric Cambisol (6.42 mg kg-1) > Eutric Cambisol (3.24 mg kg-1). In addition, the change in soil Olsen-P with a 100 kg P ha-1 surplus (soil Olsen-P efficiency) was affected by the soil organic matter (SOM), pH, and CaCO3 content, etc. In the practice of fertilization, it’s not necessary to increase the amount of P fertilizers, farmers should take measure to solve the local problem, for adjust the soil pH of Eutric Cambisol and Calcaric Cambisol, and apply more nitrogen in Luvic Phaeozems. In the area of serious soil P surplus, it is encouraged to stop applying P fertilizers for a few years to take advantage of soil accumulated P and make the high Olsen-P content decrease to a reasonable level.
Structural Reforms to Set the Growth Ambition

The effect of structural reforms on growth in Europe and Central Asia is assessed by looking separately at each supply-side channel: capital, labor, and productivity, with the last estimated using the stochastic frontier approach. By controlling for the interaction with the economic cycle, the paper also investigates whether timing matters. Improvements in human capital, regulatory quality, and government effectiveness have the most impact on potential growth, along with financial development. European Union accession may also boost growth, mainly by encouraging capital deepening. However, changes in labor market regulation and tariffs may have ambiguous effects. Applying the results to Serbia, the analysis demonstrates that closing certain structural gaps with the frontier would help boost its potential.
Site selective adsorption of the spin crossover complex Fe(phen)2(NCS) on Au(111)

The iron(II) spin crossover complex Fe(1,10-phenanthroline)2(NCS)2, dubbed Fe-phen, has been studied with scanning tunneling microscopy, after adsorption on the ‘herringbone’ reconstructed surface of Au(111) for sub-monolayer coverages. The Fe-phen molecules attach, through their NCS-groups, to the Au atoms of the fcc domains of the reconstructed surface only, thereby lifting the herringbone reconstruction. The molecules stack to form 1D chains, which run along the Au[110] directions. Neighboring Fe-phen molecules are separated by approximately 2.65 nm, corresponding to 9 atomic spacings in this direction. The molecular axis, defined by the two phenanthroline groups, is aligned perpendicular to the chain axis, along the Au 221¯ direction, thereby bridging over 5 atomic spacings, in this direction. Experimental evidence suggests that the molecular spins are locked in a mixed state in the sub-monolayer regime at temperatures between 100 K and 300 K.
Relative importance of isolation‐by‐environment and other determinants of gene flow in an alpine amphibian

A pattern of population structure called isolation‐by‐environment (IBE) evolves when gene flow connecting populations in different habitats is lower than expected. Although IBE is widespread, there is limited information on its magnitude compared with other factors influencing gene flow. We estimated the relative importance of IBE in the frog Rana temporaria in the Swiss Alps, a geographic context in which IBE should be relatively pronounced. The environmental factor potentially causing IBE was the length of the growing season, which is highly correlated with elevation. A sample of 992 individuals from 82 breeding sites were genotyped at 1827 single‐nucleotide polymorphism markers; gene flow was estimated in four ways related to FST, genetic distance, allele sharing, and distance on a population graph. Gravity modeling and random forest regression evaluated the importance of six at‐site covariates, 10 between‐site covariates, and geographic distance. There was broad agreement among analysis methods and measures of gene flow: isolation‐by‐distance (IBD) and habitat quality between sites were of highest importance, the elevation and ruggedness of the dispersal path were about half as important, and IBE was about 10–20% as important as IBD. These results combine with other evidence to suggest that population divergence across elevational gradients is underway in amphibians.
Adesão ao tratamento clínico ambulatorial da hipertensão arterial sistêmica Compliance with outpatient clinical treatment of hypertension

Objective: Assessing the compliance with outpatient treatment of hypertension. Methods: Cross-sectional study in which were studied demographic and socioeconomic variables, as well as of knowledge about the disease. The Morisky-Green Test (MGT) was applied to measure the compliance with treatment, and multiple logistic regression to identify factors associated with it. Results: There was homogeneity between compliance/non-compliance regarding gender, age, marital status, color/race, education, professional activity, number of people in the household and occupation. There was a significant association between income and compliance with treatment (p = 0.039). The hypertensive subjects guided by the community health agents had 2.21 times greater risk of non-compliance with medication compared to those guided by the team and adjustment to income of the subjects non-compliant with medication (OR = 2.21, CI 1.08 -4, 85, p = 0.033). Conclusion: Income and the guidance provided by community health agents interfered in the compliance with treatment, requiring training and the offer of fundraising practices and lifestyle changes. Descritores Cooperacao do paciente; Hipertensao/ terapia; Monitoracao ambulatorial da pressao arterial; Enfermagem de atencao primaria; Aceitacao do paciente de cuidados de saude
Does physician compensation for declaration of involuntary status increase the likelihood of involuntary admission? A population-level cross-sectional linked administrative database study

Abstract Background There is substantial variability in involuntary psychiatric admission rates across countries and sub-regions within countries that are not fully explained by patient-level factors. We sought to examine whether in a government-funded health care system, physician payments for filling forms related to an involuntary psychiatric hospitalization were associated with the likelihood of an involuntary admission. Methods This is a population-based, cross-sectional study in Ontario, Canada of all adult psychiatric inpatients in Ontario (2009–2015, n = 122 851). We examined the association between the proportion of standardized forms for involuntary admissions that were financially compensated and the odds of a patient being involuntarily admitted. We controlled for socio-demographic characteristics, clinical severity, past-health care system utilization and system resource factors. Results Involuntary admission rates increased from the lowest (Q1, 70.8%) to the highest (Q5, 81.4%) emergency department (ED) quintiles of payment, with the odds of involuntary admission in Q5 being nearly significantly higher than the odds of involuntary admission in Q1 after adjustment (aOR 1.73, 95% CI 0.99–3.01). With payment proportion measured as a continuous variable, the odds of involuntary admission increased by 1.14 (95% CI 1.03–1.27) for each 10% absolute increase in the proportion of financially compensated forms at that ED. Conclusions We found that involuntary admission was more likely to occur at EDs with increasing likelihood of financial compensation for invoking involuntary status. This highlights the need to better understand how physician compensation relates to the ethical balance between the right to safety and autonomy for some of the world's most vulnerable patients.
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2C9 and Nonsteroidal Anti‐Inflammatory Drugs

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the most commonly used analgesics due to their lack of addictive potential. However, NSAIDs have the potential to cause serious gastrointestinal, renal, and cardiovascular adverse events. CYP2C9 polymorphisms influence metabolism and clearance of several drugs in this class, thereby affecting drug exposure and potentially safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for NSAIDs based on CYP2C9 genotype (updates at www.cpicpgx.org).
Validation of mammographic x-ray spectra generated using Particle and Heavy Ion Transport code System

A Monte Carlo (MC) code is a robust method to generate a mammographic x-ray spectrum because the geometry of a mammography system can be flexible and directly modeled in MC simulation. However, simulations from MC code need to be validated before it can be reliably used for specific applications. This study aimed to generate and validate the x-ray spectra of relevant anodes used in mammography and breast tomosynthesis using Particle and Heavy Ion Transport code System (PHITS). PHITS version 3.08 was used to generate the x-ray spectra of molybdenum (Mo), rhodium (Rh), and tungsten (W) anodes. The Mo anode spectrum derived using PHITS was compared with those obtained using other MC codes. The generated spectra of all anodes were compared with the literature. Parameters including spectral shape, K characteristic x-ray yield, heel effect, and half-value layer (HVL) were used for a comparative assessment. The differences in these assessment parameters conducted by PHITS and PHITSEGS5 simulations were studied. Regarding the comparative parameters, PHITSEGS5 simulation improved the accuracy of mammographic x-ray generation compared to PHITS simulation; K x-ray and bremsstrahlung yields of the Mo anode spectrum generated by PHITSEGS5 simulation were a better agreement with those generated by other MC code simulations. The PHITSEGS5 spectra overestimated K x-ray and low-energy bremsstrahlung photons in comparison with measured spectra. Subsequently, HVLs calculated from PHITSEGS5 spectra were 1.0% (Mo/Mo) and 7.0% (W/Al) lower than those derived from measured spectra. For Mo and Rh anodes, relative difference of HVLs calculated from PHITSEGS5 spectra and those obtained from literature and measurement were within the TRS 457 acceptance criteria (±0.02 mm Al). The observed difference exceeded the acceptance criteria for W anode. Regarding existed consistency in HVL between simulation and measurement, PHITSEGS5 simulation can be reliably used to generate x-ray spectra of Mo and Rh anodes. However, its accuracy should be improved for generating W anode spectrum.