Miracle-dz/UniFAR-FTUs huggingface dataset:
Pneumonia Caused by Coronavirus 229E and Parainfluenza 3 Coinfection in a Lung Transplant Recipient

Respiratory virus are well-known causes of common colds and self-limiting upper respiratory infections in immunocompetent individuals. Conversely, in immunocompromised hosts, they are responsible for more severe manifestations associated with a significant morbidity and mortality. In lung transplant recipients, these pathogens have also been implicated in bronchiolitis syndrome and acute rejection. Infection by 2 or more viruses is uncommon, but it has been reported increasingly in recent years because of the development of newmolecular techniques. We present the case of a lung transplant recipient that developed pneumonia secondary to coronavirus 229E and parainfluenza (PIV) 3. To our knowledge, this is the first case reported in the literature. A 68-year-old man presents to the hospital with productive cough, fever, and chills over the past 2 days. His son had severe flu-like symptoms during the past week. His past medical history was significant for end-stage chronic obstructive pulmonary disease requiring double lung transplant in September 2016. He also suffered from hypertension and stroke with residual motor deficit. His antirejection regimen consisted of tacrolimus, mycophenolate mofetil, and prednisone. Hewas also taking valacyclovir, voriconazole, and atovaquone as prophylaxis. On admission, his temperature was 37.9°C, pulse of 80 beats per minute, respiratory rate of 16 breaths per minute, and blood pressure of 147/80 mm Hg. His lung examination revealed decreased breath sounds in left lower lung and mild bibasilar crackles. No wheezing was noted. Laboratory studies showed normal white blood cell count (4.3 K/uL), low hemoglobin (9.1 g/dL), normal platelet count (188 k/uL), and elevated creatinine (1.24 mg/dL). Chest x-ray revealed multifocal patchy opacifications with a nodular density in the right upper lobe measuring 1.8 2.1 cm (Fig. 1A). To further evaluate the pulmonary involvement, a chest computed tomography was ordered, which demonstrated patchy nodular ground glass opacities throughout right lung, lingula, and left lower lobe. New nodules of 6 to 9 mm were also found in right middle and lower lobes. The
Research on Pedestrian Detection Algorithm Based on Image

Pedestrian detection is an important application of target detection. It is an important foundation in many fields, such as unmanned vehicle driving, intelligent monitoring system, pedestrian analysis and robot development. Despite a lot of research, pedestrian detection methods still have many problems to be solved urgently. In order to sort out the existing pedestrian detection algorithms, this paper will summarize and analyze the advantages and disadvantages of these algorithms. The two methods of traditional algorithms and deep learning algorithms are used to discuss pedestrian detection, analyze and compare the results of the two types of algorithms, and finally target pedestrians. The detection algorithm is expected.
PROFESSIONAL DEVELOPMENT’S IMPACT ON TECHNOLOGY USE BY K-6 EDUCATORS IN A CHINESE CONTEXT: A MIXED METHODS STUDY

ii Dissertation Approval Form . iv Dedication . iv Acknowledgements . vi List of Tables . xiv List of Figures . xv Executive Summary . 1 Problem of Practice . 2 Theoretical Framework . 3 Background and Context . 3 A Needs Assessment Investigation . 4 Intervention Theoretical Framework . 5 Learning Support Interventions . 5 Research Purpose and Objective . 6 Research Design . 8 Intervention . 8 Data and Data Analysis . 8 Findings . 9 Chapter One: Technology Integration in Chinese Primary Classrooms . 12 Problem of Practice . 14 Theoretical Framework . 15 Factors Related to Technology Integration in Instructional Practices . 20 Macrosystem: Chinese Cultural Influence . 21 TECHNOLOGY INTEGRATION viii Exosystem: The Impact of Chinese Government Policies . 23 Government reforms and policies. 23 Infrastructure and school resources. 27 Mesosystem: The Impact of the School Environment . 29 Principal leadership. 29 Inservice professional development and preservice training. 32 Microsystems: Dynamic Influences within the Classroom . 33 Teacher epistemological beliefs. 33 Teacher knowledge. 36 Teacher pedagogical beliefs. 39 Teacher self-efficacy. 42 Instructional practices. 44 Student beliefs. 47 Summary . 54 Chapter Two: Assessing the Educational Technology Needs of Primary Teachers at BPS . 58 Context of Study. 59 Method . 60 Participants . 61 Instruments . 63 Teacher interview protocol. 63 Teacher survey. 64 Principal interview protocol. 68 Procedure . 69 Participant Recruitment . 69 TECHNOLOGY INTEGRATION ix Data Collection . 69 Data Analysis . 70 Quantitative data analysis. 70 Qualitative data analysis. 70 Findings and Discussion. 71 Reliability Estimates . 71 Teacher Perspective: Professional Development, Infrastructure, and School Resources . 72 Teacher Perspective: Teacher Beliefs . 77 Teacher Perspective: Instructional Practices . 85 Principal Leadership . 87 Summary . 89 Chapter Three: Exploring Teacher Professional Development . 91 Raising the Bar: A Dual Theoretical Framework. 92 Social cognitive theory. 94 Situated learning theory. 97 Professional Development as an Intervention . 100 Overview of Professional Development as an Intervention . 101 Key components of an effective PD system. 108 Professional Development Delivery Formats . 113 Face-to-face professional development programs. 114 Blended professional development programs. 120 Online professional development programs. 127 Communities of practice. 134 Summary . 142 TECHNOLOGY INTEGRATION x Chapter Four: Intervention Design: Method and Procedure . 147 Purpose of the Study . 147 Research Design . 149 Program Evaluation Plan . 150 Outcome Evaluation Plan . 151 Method .
Utilization of whey waste as a substrate for making nata de whey

Increasing in demand and imports of cheese is parallel to an increase in cheese production annually. High cheese production is directly proportional to generation of whey. Whey is considered as wastewater and usually directly disposed to environment causing a detrimental impact such as water pollution. Whey contains 55% of dairy protein and is potential to be used for nata seed growth. Therefore, it is necessary to valorise whey into a high value-added product. This research aimed to use nutrient-rich whey wastewater as a medium of development for Acetobacter xylinum bacteria in the production of nata de whey, as well as to investigate the effect of of sucrose addition to the characteristics of nata de whey . The research design used was Randomized Block Design (RBD) with 2 factors of Acetobacter xylinum (inoculum) concentration (i.e. 5, 10, and 15%) and sucrose concentration (i.e. 3, 4, and 5%). The results showed that the treatment with addition of 10% inoculum and 4% sucrose produced the nata de whey with superior quality. The resulted nata de whey has pH of 3.2 ± 0.13, total sugar of 4.24 ± 1.11%, total acid of 1.67 ± 0.08%, yield of 84.41 ± 7.27%, thickness of 1.345 ± 0.18 mm, and moisture content of 83.4 ± 1.97%, respectively.
The Role of the Ovarian Cancer G -Coupled Receptor (OGR1) in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a disease characterized by irreversible scarring of the lung that is associated with significant mortality and morbidity. The pathophysiology is incompletely understood but it is well-established that fibroblast to myofibroblast differentiation is a key feature of pulmonary fibrosis. Our lab has established that a reduction in extracellular pH is one of several important pathways responsible for the activation of latent TGF-β in the extracellular space. TGF-β activation further decreases extracellular pH and creates a feed-forward mechanism that stimulates myofibroblast differentiation and activation of additional TGF-β. Given the importance of TGF-β and extracellular acidification to the progression of pulmonary fibrosis, we sought to identify novel mechanisms that are involved in pH-dependent fibrotic signaling. The proton sensing G-Protein Coupled family of receptors are activated in acidic environments, but their role in fibrotic signaling has not been studied. Here we report that the Ovarian Cancer G-Protein Coupled Receptor1 (OGR1 or GPR68), a member of the family of proton sensing G-Protein Coupled Receptors, negatively regulates pro-fibrotic signaling. We demonstrate that OGR1 expression is significantly reduced in lung tissue from patients with IPF and TGF-β decreases OGR1 expression. In fibroblasts, a reduction in expression of OGR1 (OGR knockout lung fibroblasts) and knockdown (OGR siRNA), promotes in vitro myofibroblast differentiation. In contrast, OGR1 overexpression inhibits myofibroblast differentiation. Finally, we demonstrate that OGR1 negatively regulates TGF-β stimulation through inhibition of focal adhesion kinase (FAK) phosphorylation. Our results suggest that preserving OGR1 expression may represent a novel therapeutic strategy in pulmonary fibrosis.
Clinical effectiveness of complete revascularization versus infarct-related artery-only percutaneous coronary revascularization for multivessel disease ST-segment elevation myocardial infarction

Objectives: The purpose of this study was to evaluate the event-free survival from major adverse cardiac events for ST-segment elevation myocardial infarction (STEMI) patients with multivessel disease (MVD) as a function of whether they underwent infarct-related artery (IRA)- only percutaneous coronary intervention (PCI) or complete revascularization at index admission. Background: The optimal management of patients with STEMI and MVD while undergoing primary PCI (P-PCI) is uncertain. Methods and Results: STEMI patients with MVD undergoing P-PCI between April 1, 2012, and March 31, 2014, were subdivided into those who underwent complete revascularization during index admission (n = 150) and IRA-only revascularization (n = 156). Complete revascularization was performed at index admission of P-PCI. The primary endpoint was a composite of all-cause death, recurrent MI, heart failure (HF), and ischemia-driven revascularization within 24 months. Patient groups were differed at baseline by gender and prevalence of HF. The average door-to-balloon time was significantly higher in the complete revascularization group. The primary endpoint occurred in 11.0% of the complete revascularization group versus in 23% of the IRA-only revascularization group (hazard ratio: 0.51; 95% confidence interval: 0.34–0.93; P = 0.039). There was a significant reduction in death; a nonsignificant reduction in all primary endpoint components was seen. Conclusions: In patients presenting for P-PCI with MVD, complete revascularization at index admission significantly lowered the rate of the primary composite endpoint at 24 months compared with treating IRA-only.
Families and Health: the Negative Side of Social Ties

Research on a range of illnesses has demonstrated a protective effect for social ties and social support, and has begun to address the potential mechanisms by which this effect is brought about. More recently, researchers examining the positive effects of social ties have also uncovered unexpected negative consequences. The supportive and non-supportive aspects of social relations are weakly correlated, indicating that both of these two domains of social experience need to be considered to understand the influence of family and other social ties on health. The purpose of this paper is to illustrate through selective examination of the literature how social support, particularly in the form of family ties, may increase risk for negative rather than positive health outcomes. In addition, we provide a framework for research to more fully elucidate this area.
Prognostic Cut Point for Breast Cancer Age of Diagnosis

Background: In oncology studies, categorizing a quantitative prognostic variable or determining cut point is aimed at categorizing individuals into homogenous groups. Such categorizations are useful for treatment recommendations and clinical trial design. Objectives: This article aims at determining the cut point for breast cancer diagnosis age by factors affecting the patients’ survival, using cure model. Methods: In this longitudinal study, a total 559 patients with breast cancer referring to breast cancer research center, Tehran, Iran, from 1986 to 2006 entered the study. Patients were followed until 2013. The last status of patients was recorded, using telephone conversation. Then, the cut point of breast cancer diagnosis age was determined, using change point cure model with survival-related covariates and R v.2. 15.0 software. Results: In the present study, the mean age of diagnosis was reported 46.31 ± 11.17. Median time of follow-up was 68.36 months with the range of 0.89 to 324. The results showed that age cut point was 49.45 (± 0.64). In young group, one unit increase in tumor size led to 57% reduction in the chance of cure. In old group, the chance of recovery declined by 51%. In old group, the chance of cure among those with lymph node declined by %61 compared to those without lymph node. In the young group, this variable was not significant. Level of education, type of surgery, and estrogen receptor had no significant relationship with cure in none of the age groups at 5% error level. Conclusions: The results showed that the effect of age in breast cancer prognosis is adjusted at 50-year cut point, leading to two relatively homogeneous groups. This cut point is effective in assessing predictive and prognostic factors in breast cancer. The difference between effect of tumor size and effect of lymph node involvement in different age groups can be helpful in determining more appropriate therapeutic strategies.
Is There a Relationship Between Audiogram Shape and the Intensity and Duration of Tinnitus?

Abstract Chronic tinnitus is often associated with hearing impairment, but it cannot be asserted that only hearing loss causes tinnitus. Audiograms of patients with tinnitus show that hearing loss occurred more often at high frequencies than at low frequencies. The aim of this study was to analyse the audiogram shapes of patients with chronic tinnitus and to identify the relationship between the shape of the audiogram and intensity and duration of tinnitus. This investigation was a cross case series study conducted at a general hospital in Kraljevo on patients with chronic subjective tinnitus. The study included 43 patients of both genders and of different ages. We used audiometry (measuring the threshold of hearing for frequencies from 250, 500, 1000, 2000, 4000 and 8000 Hz) and tympanometry. Each patient reported the intensity of tinnitus in each ear on a visual analogue scale (VAS1) and stated the duration of tinnitus for each ear. Our research showed that patients with chronic tinnitus had a characteristic audiogram with progressive hearing loss to high frequencies. Th is difference was significantly increased starting from lower to higher frequencies, and the most hearing-decreased range (“edge”) was between 2000 and 4000 Hz. We did not find a strong link between the tinnitus intensity measured by the visual analogue scale and tinnitus duration on one side and hearing loss in the studied patients and audiogram shape on the other side. The duration of tinnitus was most associated with hearing loss at 2000 Hertz, but even that was not significant.
KASTAMONU'DA YÖRESEL YİYECEK İÇECEK HİZMETİ SUNAN RESTORANLARA İLİŞKİN TÜKETİCİ ŞİKAYETLERİNİN DEĞERLENDİRİLMESİ: TRİPADVİSOR ÖRNEĞİ

Sosyal medyada cevrim ici yorum sitelerinin populerlesmesiyle birlikte cevrim ici tuketici yorumlari tuketici satin alma kararinda oldukca onemli bir rol oynayan bir pazarlama olgusu haline gelmistir. TripAdvisor.com web sitesi gibi cevrim ici yorumlarin yapildigi web sitelerinde yer alan olumlu ve olumsuz yorumlar turistik hizmet satin alma niyetinde olan kisileri oldukca etkilemektedir. Arastirmanin amaci TripAdvisor web sitesinde Kastamonu’da yoresel yemek hizmeti sunan restoranlarla ilgili yapilan olumsuz yorumlarin degerlendirilmesidir. Kastamonu’da yoresel yemek hizmeti sunan 10 isletmeye yonelik olumsuz yorumlar icerik analizi yontemiyle incelenmistir. Tripadvisor.com sitesinde 31.12. 2018 tarihine kadar yapilan yorumlar icerik analizine tabi tutulmus, yapilan 760 yorumun 448’inin olumsuz yonde oldugu tespit edilmistir. Kastamonu’da yoresel yemek hizmeti sunan restoranlarla ilgili olumsuz yorumlar sirasiyla yiyecek icecekle ilgili sikâyetler, servisle ilgili sikâyetler, fiyatla ilgili sikâyetler, hizmet ortamiyla ile ilgili sikâyetler, personel ile ilgili sikâyetler ve menuyle ilgili sikâyetler olmak uzere 6 ana kategori 16 alt kategoriden olusmaktadir.
On Resilient Control for Secure Connected Vehicles: A Hybrid Systems Approach

According to the “Internet of Things Forecast” conducted by Ericsson, connected devices will be around 29 billion by 2022. This technological revolution enables the concept of Cyber-Physical Systems (CPSs) that will transform many applications, including powergrid, transportation, smart buildings, and manufacturing. Manufacturers and institutions are relying on technologies related to CPSs to improve the efficiency and performances of their products and services. However, the higher the number of connected devices, the higher the exposure to cybersecurity threats. In the case of CPSs, successful cyberattacks can potentially hamper the economy and endanger human lives. Therefore, it is of paramount importance to develop and adopt resilient technologies that can complement the existing security tools to make CPSs more resilient to cyber-attacks. By exploiting the intrinsically present physical characteristics of CPSs, this dissertation employs dynamical and control systems theory to improve the CPS resiliency to cyberattacks. In particular, we consider CPSs as Networked Control Systems (NCSs), which are control systems where plant and controller share sensing and actuating information through networks. This dissertation proposes novel design procedures that maximize the resiliency of NCSs to network imperfections (i.e., sampling, packet dropping, and network delays) and denial of service (DoS) attacks. We model CPSs from a general point of view to generate design procedures that have a vast spectrum of applicability while creating computationally affordable algorithms capable of real-time performances. Indeed, the findings of this research aspire to be easily applied to several CPSs applications, e.g., power grid, transportation systems, and remote
Effects of tidal volume and positive end‐expiratory pressure during resuscitation of very premature lambs

Background: Guidelines recommend neonatal resuscitation without controlling tidal volume or positive end‐expiratory pressure (PEEP). However, these may improve gas exchange, lung volume and outcome. Aim: To investigate resuscitation of very premature lambs with a Laerdal bag without PEEP versus volume guarantee ventilation with PEEP. Methods: Anaesthetized lambs (n=20) delivered at 125 d gestation were randomized to three groups receiving 15 min resuscitation: (1) Laerdal bag and no PEEP; (2) ventilation with a tidal volume of 5 ml/kg and 8 cm H2O PEEP; (3) ventilation with 10 ml/kg and 8 cm H2O PEEP. They were then all ventilated for 2 h with tidal volumes of 5 or 10 ml/kg, and 8 cm H2O PEEP. Ventilation parameters and blood gases were recorded. Results: Different tidal volumes affected PaCO2 within minutes, with 10 ml/kg causing severe hypocarbia. PEEP had little effect on PaCO2. Oxygenation improved significantly with PEEP of 8 cm H2O, irrespective of tidal volume.
Nasal and Laryngeal Non-Hodgkin’s Lymphoma: A Case Report

Among head and neck malignancies, lymphoma is the second most frequent cause. They can develop in the head and neck lymph nodes or as extranodal determinations. The onset of malignant lymphoma outside of lymph node registers increasingly frequent, currently over 30% of malignant lymphoma are diagnosed as taking place outside the lymph nodes. The aim of this paper is to describe a rare case of double location of non-Hodgkin’s nasal and laryngeal lymphoma and the modalities of diagnosis and treatment even the lack of studies in the literature.
Aggregate stability and carbon stocks in Forest conversion to different cropping systems in Southern Amazonas, Brazil

Abstract The process of converting natural ecosystems in cultivated areas, as well as use and land management systems have provided changes in aggregate stability and soil carbon stocks levels. The objective of this work was to evaluate the stability of aggregates and carbon stock in areas under forest conversion to different cropping systems, using statistical tools. Grids were established according to the culture dimensions, samples were taken at the crossing points of the grids at depths 0.00–0.05; 0.05–0.10; and 0.10–0.20 m, with 80 sampling points in each area, totaling 240 per area. At each sampling point, samples were collected with a preserved structure in the shape of a clod to determine the physical and chemical attributes, with a total of 960 samples in the four areas evaluated. The conversion process influenced soil aggregation, as measured by increased clay fraction dispersion and decreased WAD, GAD and aggregate classes >2.00 mm; The attributes were shown at the limit of the degree of spatial dependence, varying from moderate to strong; In the multivariate analysis, the forest and cupuaçu areas presented similar behavior, with values of OC, CS, silt, clay and classes of aggregates 2–1 mm, <1mm and ASI, above average.
Brain computation by assemblies of neurons

Significance Our expanding understanding of the brain at the level of neurons and synapses, and the level of cognitive phenomena such as language, leaves a formidable gap between these two scales. Here we introduce a computational system which promises to bridge this gap: the Assembly Calculus. It encompasses operations on assemblies of neurons, such as project, associate, and merge, which appear to be implicated in cognitive phenomena, and can be shown, analytically as well as through simulations, to be plausibly realizable at the level of neurons and synapses. We demonstrate the reach of this system by proposing a brain architecture for syntactic processing in the production of language, compatible with recent experimental results. Assemblies are large populations of neurons believed to imprint memories, concepts, words, and other cognitive information. We identify a repertoire of operations on assemblies. These operations correspond to properties of assemblies observed in experiments, and can be shown, analytically and through simulations, to be realizable by generic, randomly connected populations of neurons with Hebbian plasticity and inhibition. Assemblies and their operations constitute a computational model of the brain which we call the Assembly Calculus, occupying a level of detail intermediate between the level of spiking neurons and synapses and that of the whole brain. The resulting computational system can be shown, under assumptions, to be, in principle, capable of carrying out arbitrary computations. We hypothesize that something like it may underlie higher human cognitive functions such as reasoning, planning, and language. In particular, we propose a plausible brain architecture based on assemblies for implementing the syntactic processing of language in cortex, which is consistent with recent experimental results.