Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies

Background: Tauopathies are a group of neurodegenerative diseases associated with the accumulation of misfolded tau protein. The mechanisms underpinning tau-dependent proteinopathy remain to be elucidated. A protein quality control pathway within the endoplasmic reticulum, the unfolded protein response (UPR), has been suggested as a possible pathway modulating cellular responses in a range of neurodegenerative diseases, including those associated with misfolded cytosolic tau. Objective: In this study we investigated three different clinically defined tauopathies to establish whether these diseases are accompanied by the activation of UPR. Methods: We used PCR and western blotting to probe for the modulation of several reliable UPR markers in mRNA and proteins extracted from three distinct tauopathies: 20 brain samples from Alzheimer’s disease patients, 11 from Pick’s disease, and 10 from progressive supranuclear palsy. In each disease samples from these patients were compared with equal numbers of age-matched non-demented controls. Results: Our investigation showed that different markers of UPR are not changed at the late stage of any of the human tauopathies investigated. Interestingly, UPR signatures were often observed in non-demented controls. Conclusion: These data from late-stage human cortical tissue report an activation of UPR markers within the aged brain across all cohorts investigated and further support the emerging evidence that the accumulation of misfolded cytosolic tau does not drive a disease-associated activation of UPR.
Cost-effectiveness of upper extremity dry needling in the rehabilitation of patients with stroke

Introduction: Dry needling (DN) has been shown to be effective for the treatment of upper extremity hypertonia in patients with stroke. Purpose: To evaluate the cost-effectiveness of DN in patients with stroke. Methods: A cost-effectiveness analysis was performed in a research study conducted at a Spanish public hospital where patients were classified into two groups with or without DN. Hypertonia was measured using the Modified Modified Ashworth Scale (MMAS), and quality of life (QOL) was assessed using the EuroQoL 5-dimension questionnaire. Data regarding the effects and costs of physiotherapy were presented by calculating the mean and 95% confidence interval. The health outcomes were evaluated considering the rate of responders to the treatment based on the MMAS. Spanish preference weights were used to estimate quality-adjusted life years (QALYs). The incremental cost-effectiveness ratio (ICER) and incremental cost-utility ratio (ICUR) were calculated to determine the economic value of DN. Results: Eighty patients with stroke in the subacute stage of recovery were selected to participate in this study. Based on the rate of responders, the ICER of the DN group was very low. Despite the sensitivity analysis performed, the results of the ICUR were not encouraging. Discussion: Cost-effectiveness with responder rate results were favourable for the DN group and were confirmed by the sensitivity analysis according to levels of care. In addition, our findings revealed that 4 weeks of treatment could be more cost-effective than 8 weeks. DN treatment of the upper extremity appears to be cost-effective based on the rate of responders measured using the MMAS scale.
PENGARUH UKURAN PERUSAHAAN, KEPEMILIKAN INSTITUSIONAL, PROFITABILITAS DAN PERUBAHAN LABA TERHADAP NILAI PERUSAHAAN

The purpose of this study was to determine the effect of firm size, institutional ownership, profitability, and earnings changes on firm value in the food and beverage subsector listed on the Indonesia Stock Exchange (IDX) for the 2017-2019 period. The population used in this study were 31 companies. While the sample used as many as 16 companies selected by using purposive sampling technique. Multiple linear regression analysis technique is the analysis technique used in this study. Based on the result of the analysis, firm size, institutional ownership, profitability, and earnings changes have a positive effect on firm value.
An empirical analysis of the influence of financialization on investment in Russia

This paper tries to estimate the impact of financialization on fixed investment in Russia. The work is carried out by using panel data based on reports of non-financial publicly listed companies for 1999–2019. The study finds that financial expenses aimed at paying interest on external financing and paying dividends — that is, focusing on shareholder value, and hence decreasing the internal funds of companies, reduce real investments. Financial incomes have shown the crowding-out effect for large companies. Financial incomes as additional “free” funds in large companies are not perceived as an opportunity to accumulate fixed assets. Managers prefer to increase ­financial investments instead of real ones. In small and medium-sized companies, financial incomes, however, drive the growth of physical investment. This is because small firms, at a particular stage in their lives, find it more profitable to invest in their own growth. The results from the general sample, without dividing by size, indicate that financialization in Russia clearly reduces real investment.
Vortex-Induced Motion of Deep-Draft Semisubmersibles: A CFD-Based Parametric Study

Deep Draft Column Stabilized Floaters (DDCSFs) provide a viable dry-tree platform for ultra-deep water applications. A particular area of concern for this concept is its susceptibility to Vortex-Induced-Motions (VIM) due to its deeper draft that results in higher column slenderness ratios than conventional semisubmersibles. The VIM characteristics of platforms have traditionally been assessed through experimental measurements but in recent years Computational Fluid Dynamics (CFD) has been used alongside experiments to predict VIM. Besides solving problems that cannot be addressed by other analysis methods, CFD can be seamlessly integrated into the overall concept design cycle where different geometric parameters can be varied to optimize the performance of the platform. While tank experiments give little fluid flow information without extensive instrumentation, CFD solutions provide flow details that can be used to improve design. CFD also provides a cost-effective solution given the high cost of experiments and facility scheduling constraints. One such DDCSF concept is the Paired-Column semi-submersible (PC-Semi) and the design has a pair of columns instead of one at each of the four sides of the platform. Several design parameters of the columns, like the inter-column spacing, the cross-sectional areas, and the shape of the respective columns can be tuned to minimize the heave response. This study takes a detailed look at the effect of the change in the column-dependent parameters on the overall VIM characteristics of the PC semisubmersible. A two-step approach is presented in which the first step is to identify aspects of the physics that are unique to VIM and then formulate a methodology to predict it within the framework of a set of commercially available CFD tools. The methodology is verified further through a comparison with available experimental data. The second step is to apply the verified methodology and CFD tools to predict the VIM performance of a range of PC-Semi concepts obtained through a systematic variation of the column-dependent design parameters in model scale. Through this exercise the critical design parameters that can either improve or prove detrimental to the VIM performance of the PC-Semi design are identified.Copyright © 2015 by ASME
Impact of Perceived Stress and Immune Status on Decision-Making Abilities during COVID-19 Pandemic Lockdown

The ability to make risky decisions in stressful contexts has been largely investigated in experimental settings. We examined this ability during the first months of COVID-19 pandemic, when in Italy people were exposed to a prolonged stress condition, mainly caused by a rigid lockdown. Participants among the general population completed two cognitive tasks, an Iowa Gambling Task (IGT), which measures individual risk/reward decision-making tendencies, and a Go/No-Go task (GNG), to test impulsivity, together with two questionnaires, the Perceived Stress Scale and the Depression, Anxiety and Stress Scales. The Immune Status Questionnaire was additionally administered to explore the impact of the individual health status on decision making. The effect of the questionnaires scores on task performance was examined. The results showed that higher levels of perceived stress and a more self-reported vulnerable immune status were associated, separately, with less risky/more advantageous choices in the IGT in young male participants but with more risky/less advantageous choices in older male participants. These effects were not found in female participants. Impulsivity errors in the GNG were associated with more anxiety symptoms. These findings bring attention to the necessity of taking into account decision-making processes during stressful conditions, especially in the older and more physically vulnerable male population.
Feasibility of Implementing Physical Activity Behavior Change Counseling in an Existing Cancer-Exercise Program

Purpose: This study examined the feasibility and acceptability of implementing research-tested physical activity (PA) behavior change counseling (BCC) sessions in an existing cancer-exercise program, and the preliminary effects on cancer survivor’s self-efficacy and PA. Methods: Participants were cancer survivors undergoing or within six-months of completing cancer treatment(s), and exercise program staff. Cancer survivors were randomized to receive the exercise program plus PABCC, or the standard exercise program. Feasibility and acceptability were assessed by recruitment, adherence, satisfaction, and a focus group with program staff. Qualitative data were analyzed using descriptive thematic analysis. Self-report questionnaires measured PA and exercise self-efficacy. Results: Recruitment was 33 out of 93 (36.7%), and n = 13 (39%) provided post-program data. Cancer survivors enjoyed PABCC sessions, but reported face-to-face delivery was an added time burden. Program staff expressed desire to implement PABCC, but perceived staff capacity and time as barriers to sustainability. Exercise self-efficacy increased by 21.5% in the PABCC group vs. 4.2% in the control. PA increased by 81.3% in the PABCC group vs. 16.6% in the control group. Conclusions: Implementing PABCC in an existing cancer-exercise program was acceptable and promising for increasing moderate to vigorous PA, but additional research is needed to enhance the feasibility and sustainability of translating efficacious behavioral interventions into existing cancer-exercise programs.
When nature calls back: sustaining behavioural change in rural Pakistan

We implement a mixed method approach that combines a randomized controlled trial and qualitative data collection to assess whether, and if so how, behavioural change can be sustained. We do so in the context of Pakistan’s national sanitation strategy to combat open defecation, CommunityLed Total Sanitation. Our findings demonstrate that continued follow-up activities, that build on the original intervention, reduced reversal to unsafe sanitation, but only where initial conditions are unfavourable —i.e. poor public infrastructure and low-quality sanitation facilities. Promotion efforts are hence best targeted towards those that face larger difficulties in constructing and maintaining high quality sanitation. (JEL C93, I12, I15, I18, O18, Q53)
Historical exposure to wastewater disposal reinforces the stability of sediment bacterial community in response to future disturbance

Given that long-term treated wastewater discharge may alter the microbial community of the recipient coast, it is important to evaluate whether and how the community's stability is impacted. We constructed microcosms using coastal sediments with (near-coast) and without (far-coast) a wastewater disposal history and compared the communities’ responses to p-chloroaniline (PCAN, a typical organic pollutant) in low (10 mg/L) and high (100 mg/L) concentrations. Compared to the far-coast community, the near-coast community drove faster PCAN attenuation and nitrate generation. More significant negative correlations were observed between the alpha-diversity indices and PCAN concentrations in the far-coast communities than the near-coast ones. The community turnover rate, represented by the slopes of the time–decay curves, was slower for the near-coast community (−0.187) than that for the far-coast community (−0.233), but only when the PCAN was added in low concentration. Our study revealed that the long-term wastewater disposal may cause the sediment bacterial community to be less sensitive and more stable in response to a future disturbance, demonstrating a significant historical effect of environmental context on the coastal microbial community's stability.
Corrosion of URLs

The aim of this study is to analyze the accessibility, corrosion and half-life of URLs cited in the articles of Indian LIS conference proceedings published during 2001 to 2010. A total of 5,698 URLs cited in the 1,700 articles were examined. The percentage of URLs increased from 39.10 percent in 2001 to 73.47 percent in 2009. The study found that 50.09 percent of URLs were not accessible at the time of testing and the remaining 49.91 percent of URLs were accessible. The HTTP 404 error message – “file not found” was the overwhelming message encountered and represented 53.29 percent of all HTTP messages. The study also noticed that the average half-life of URLs of missing URLs was estimated to be 4.94 years. Even though there are various retrieval tools being used to recover vanished URLs, still there is a need to improve such tools.
Fashion and Its Social Agendas: Class, Gender, and Identity in Clothing

It has long been said that clothes make the man (or woman), but is it still true today? If so, how has the information clothes convey changed over the years? Using a wide range of historical and contemporary materials, Diana Crane demonstrates how the social significance of clothing has been transformed. Crane compares 19th-century societies - France and the United States - where social class was the most salient aspect of social identity signified in clothing with late 20th-century America, where lifestyle, gender, sexual orientation, age and ethnicity are more meaningful to individuals in constructing their wardrobes. Today, clothes worn at work signify social class, but leisure clothes convey meanings ranging from trite to political. In today's multicode societies, clothes inhibit as well as facilitate communication between highly fragmented social groups. Crane extends her comparison by showing how 19th-century French designers created fashions that suited lifestyles of Paris elites but that were also widely adopted outside France. By contrast, today's designers operate in a global marketplace, shaped by television, film and popular music. No longer confined to elites, trendsetters are drawn from many social groups, and most trends have short trajectories. To assess the impact of fashion on women, Crane uses voices of college-aged and middle-aged women who took part in focus groups. These discussions yield fascinating information about women's perceptions of female identity and "Fashion and Its Social Agendas" stands out as a critical study of gender, fashion and consumer culture.
Characterizations of Twenty (2020-2021) Proposed Discrete Distributions

In this paper, certain characterizations of twenty newly proposed discrete distributions: the discrete gen- eralized Lindley distribution of El-Morshedy et al.(2021), the discrete Gumbel distribution of Chakraborty et al.(2020), the skewed geometric distribution of Ong et al.(2020), the discrete Poisson X gamma distri- bution of Para et al.(2020), the discrete Cos-Poisson distribution of Bakouch et al.(2021), the size biased Poisson Ailamujia distribution of Dar and Para(2021), the generalized Hermite-Genocchi distribution of El-Desouky et al.(2021), the Poisson quasi-xgamma distribution of Altun et al.(2021a), the exponentiated discrete inverse Rayleigh distribution of Mashhadzadeh and MirMostafaee(2020), the Mlynar distribution of Fr¨uhwirth et al.(2021), the ﬂexible one-parameter discrete distribution of Eliwa and El-Morshedy(2021), the two-parameter discrete Perks distribution of Tyagi et al.(2020), the discrete Weibull G family distribution of Ibrahim et al.(2021), the discrete Marshall–Olkin Lomax distribution of Ibrahim and Almetwally(2021), the two-parameter exponentiated discrete Lindley distribution of El-Morshedy et al.(2019), the natural discrete one-parameter polynomial exponential distribution of Mukherjee et al.(2020), the zero-truncated discrete Akash distribution of Sium and Shanker(2020), the two-parameter quasi Poisson-Aradhana distribution of Shanker and Shukla(2020), the zero-truncated Poisson-Ishita distribution of Shukla et al.(2020) and the Poisson-Shukla distribution of Shukla and Shanker(2020) are presented to complete, in some way, the au- thors’ works.
Potato processing in Nairobi, Kenya: current status and potential for further development

A market survey identified potato products and characterized the potato processing industry in Nairobi. Potato products produced and sold locally include chips, crisps, #bhajia#, #chevra#, and some frozen French fries. Chips (USA, French fries) and bhajia are fresh potato products cooked and sold immediately where made; their production involves very little mechanization. Crisps (USA, chips) processing, on the other hand, is a 6-step process and this product is marketed in supermarkets and kiosks. The market for chips is broad, but the need is currently met by lowtechnology vendors as opposed to industrial producers. Crisps appeal more to high income groups, with about 1% of the annual national potato production going to make crisps in Nairobi. Frying oil and fresh potato constitute the most expensive processing components followed by labor, energy, equipment, and packaging. Processors of both chips and crisps preferred a particular potato type, although crisp processors were very specific about the qualities necessary for a high quality product. The major constraint identified by processors was the low quality of fresh potatoes. Other problems included the high capital investment required to purchase modern equipment, constant power failures, and water shortages that result in high losses. Nonetheless, the crisps and chips industry is an expanding market with unrealized potential. (Resume d'auteur)
DenseNet-CNN Architectural Model for Detection of Abnormality in Acute Pulmonary Edema

-Acute pulmonary edema (EPA) is a condition of emergency respiratory distress that results from the sudden and rapid build-up of fluid into the lungs. Rapid screening of EPA patients is necessary so that radiologists can make the prognosis as early as possible. In addition, reliance on the expert’s knowledge of reasoning also hinders the diagnostic process. This research was conducted by developing an architectural model for machine learning systems with a deep learning approach. With the concept of representative learning, the denseNet-CNN algorithm connects each layer to another by means of a feed-forward. The data used is Image CXR-14 specifically labeled pulmonary edema pathology. The size of each CXR-14 image is 1024 × 1024 with a value of 8 bits grayscale. The size of each CXR-14 image is 1024 × 1024 with a value of 8 bits grayscale. The architectural model development stages consist of the preparation stage, data resampling, data training and data testing. Optimizer parameters used are Adam’s optimizer, learning rate of 0.0001 and weight decay = 1e-5 and the loss used is binary cross entropy. The resulting mean AUROC analysis showed the sensitivity value of the 10% dataset was 71.493% and the specificity value of 10.011% was obtained at the second hold of the k-fold cross validation method after holdout validation, so that the resulting model was valid. The detection system developed from the denseNet-CNN model is expected to help radiologists identify abnormalities in CXR images quickly, precisely, and consistently. The denseNet-CNN model is also developed in the form of a heatmap visualization by localizing the features you are looking for. With localization in the form of a heat map, detection of pathological abnormalities of PEA is easier to do and to be recognized.
Flicker caused by phase jumps

Phase jumps into the operating voltage produce flicker. The measurement of flicker is defined in IEC 61000-4-15. The requirements for digital working instruments are at the present time under consideration. Flicker measurements in several countries and systematic comparison measurements with existing flickermeters have shown drastically different measurement results in the presence of phase jumps. In order to give more detailed specifications the necessary sampling rate is derived from the fact that phase jumps require a high-sampling rare (36 kHz for 230 V/60 Hz systems or 43.2 kHz for 120 V/60 Hz systems respectively) for adequate phase resolution. The type test of flickermeters should be expanded; a set of reference values were given. Copyright © 2006 John Wiley & Sons, Ltd.
Effective Categorization of Tolerance to Salt Stress through Clustering Prunus Rootstocks According to Their Physiological Performances

The effects of climate change on traditional stone fruit producing areas, together with the generation of new varieties with lower chilling requirements that allow the cultivation of previously unexplored areas, are setting up a challenging scenario for the establishment of productive orchards that must be more efficient in their capacity to adapt to new edaphoclimatic conditions. In this context, the rootstock breeding programs are a key piece in the agronomic strategy to achieve this adaptation through the development of rootstocks compatible with the new varieties and capable of transferring their tolerance to stress. An effective categorization of phenotypes within the germplasm involved in a plant breeding program is of utmost importance. Through the measurement of physiological parameters in both roots and leaves, tolerance to saline stress (120 mM NaCl) was evaluated in seven Prunus rootstocks whose genetic background included representatives of the subgenera Prunus, Cerasus, and Amygdalus. To group the genotypes according to their physiological performance under salt stress, an agglomerative hierarchical clustering was applied. The genotypes were grouped into three clusters containing rootstocks very sensitive (‘Mazzard F12/1’), moderately tolerant (‘Maxma 60’, ‘Cab6P’ and ‘AGAF 0204-09’), and tolerant (‘Mariana 2624’, ‘Garnem’ and ‘Colt’) to salt stress. ‘Mariana 2624’, a plum-based rootstock, was identified as the most tolerant Prunus rootstock. The information reported is valuable both in the productive context, for the selection of the most appropriate rootstocks to establish an orchard, and in the context of plant breeding programs, when choosing parents with outstanding traits to obtain progenies tolerant to salt stress.