Miracle-dz/UniFAR-FTUs huggingface dataset:
445PD ASCEND-6: single-arm, open label, multicenter phase 1/2 study of ceritinib in Chinese pts with advanced ALK-rearranged (ALK+) non-small cell lung cancer (NSCLC) previously treated with crizotinib

L. Zhang, Y. Shi, D.S. W. Tan, B. Hu, L. Xiaoqing, Y. Cheng, J. Zhou, T. An, Y. Lu, B. Zhu, C. Bai, A. Jappe, V.Q. Passos, Y.Y. Lau, Q. Wang, Y-L. Wu Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China, Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Medical Oncology, National Cancer Center, Singapore, Clinical Pharmacology, Peking Union Medical College Hospital, Beijing, China, Pulmonary Oncology, 307 Hospital of the Academy of Military Medical Sciences, Cancer Center, Beijing, China, Thoracic Oncology, Jilin Province Cancer Hospital, Changchun, China, Respiratory and Thoracic Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, Thoracic Oncology, Beijing Cancer Hospital, Beijing, China, Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China, Oncology, Xinqiao Hospital, Third Military Medical University, Chongqing, China, Pulmonary Medicine, Shanghai Respiratory Research Institute, Shanghai, China, Oncology, Novartis Pharma AG, Basel, Switzerland, Oncology, Novartis Pharmaceutical Corporation, East Hanover, NJ, USA, Biometrics and Data Management, Beijing Novartis Pharma Co., Ltd, Beijing, China, Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangzhou, China
Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

Porcine epidemic diarrhea virus is an alphacoronavirus responsible for significant morbidity and mortality in pigs. A key determinant of viral tropism and entry, the PEDV spike protein is a key target for the host antibody response and a good candidate for a protein-based vaccine immunogen. We used electron microscopy to evaluate the PEDV spike structure, as well as pig polyclonal antibody responses to viral infection. The structure of the PEDV spike reveals a configuration similar to that of HuCoV-NL63. Several PEDV protein-protein interfaces are mediated by non-protein components including a glycan at Asn264 and two bound palmitoleic acid molecules. The polyclonal antibody response to PEDV infection shows a dominance of epitopes in the S1 region. This structural and immune characterization provides new insights into coronavirus spike stability determinants and explores the immune landscape of viral spike proteins.
GLOBAL EXISTENCE AND ASYMPTOTIC BEHAVIOR IN A THREE-DIMENSIONAL TWO-SPECIES CHEMOTAXIS-STOKES SYSTEM WITH TENSOR-VALUED SENSITIVITY

In this paper, we deal with a two-species chemotaxis-Stokes system with Lotka-Volterra competitive kinetics under homogeneous Neu- mann boundary conditions in a general three-dimensional bounded domain with smooth boundary. Under appropriate regularity assumptions on the initial data, by some L p -estimate techniques, we show that the system possesses at least one global and bounded weak solution, in addi- tion to discussing the asymptotic behavior of the solutions. Our results generalizes and improves partial previously known ones.
Yeni Bir Veri Kümesi (RidNet) Kullanarak Kontrolsüz Ortamda Yüz İfadesi Tanımanın Derin Öğrenme Yöntemleri ile İyileştirilmesi

Bu calismada, internetten genel erisime acik goruntuler kullanilarak olusturulan veri kumesi (RidNet) ile yedi farkli yuz ifadesi icin derin ogrenme yontemleri kullanilarak duygu tanima islemi yapilmistir. Daha sonra AlexNet, GoogLeNet ve ResNet101 gibi literaturdeki taninmis evrisimli sinir aglari mimarileri ile RidNet uzerinden transfer ogrenimi yapilmistir. Compound Facial Expressions of Emotion (CE) ve Static Facial Expressions in the Wild (SFEW) veri kumeleri test veri kumeleri olarak belirlenmistir. Ilk olarak yapilan deneysel calismalar ile en iyi siniflandirma performansini gosteren evrisimli sinir agi mimarisi belirlenmistir. Bu evrisimli sinir agi AffectNet, The Karolinska Directed Emotional Faces (KDEF) ve RidNet ile egitilmistir. AffectNet, KDEF ve RidNet ile egitilmis aglar kontrollu ortamda olusturulan veri kumesi (CE) ile test edildiginde benzer siniflandirma basarimlari elde edilmistir. Kontrolsuz ortamdaki test veri kumesinde (SFEW) ise RidNet ile egitilen ag diger aglara belirgin bir ustunluk saglamistir.
Obesidade materna e suas consequências na gestação e no parto: uma revisão sistemática

Background: The maternal overweight occurs in 25-30% of pregnancies in Brazil. However, only recently have been evaluated the impact of obesity on pregnancy outcomes. Objective: To evaluate, based on national and international publications, the consequences of maternal obesity in pregnancy, childbirth and neonatal outcomes. Methods: A systematic review of the literature on obesity in pregnancy in MEDLINE, LILACS, Embase and Cochrane library. The outcomes assessed were maternal disorders, complications in childbirth and neonatal outcomes. Results and discussion: Among 10,815 articles initially selected between June and December 2013, only 23 were in accordance with the criteria set. Of these, 1 presented level of evidence A, 13, level of evidence B, and 9 articles, levels of evidence C or D. Most of the selected publications were referring to maternal complications and delivery. However, publications with the highest level of evidence assessed neonatal outcomes. Conclusion: Maternal obesity is associated with development of endocrine disorders, cardiovascular events and occurrence of instrumental delivery. Neonatal outcomes include congenital malformations, low Apgar scores, macrosomia and neonatal death.
Characterization of Recovered Polyvinylchloride by Size Exclusion Chromatography and Triple Detectors Technique

Abstract Polyvinyl chloride (PVC) is an indispensable compound that accounts for 66% of the water distribution infrastructure and 75% of sanitary sewer pipe applications in the U.S.A. In this study PVC resin was recovered by solvent extraction from a postconsumer PVC pipe. The recovered PVC (PVC-R) was characterized by a multi-detector size exclusion chromatography system eluted with tetrahydrofuran (THF) at 30 °C. The values of the Mark-Houwink-Kuhn-Sakurada (MH) parameters of the PVC-R were obtained by averaging three replicable experiments and the results were comparable with the reported values of pure PVC. The Stockmayer-Fixman plot of the PVC-R in THF had a curved shape which is due to the notorious tendency of the PVC molecules to remain partly associated in supermolecular aggregates even if the PVC is dissolved in a good solvent. As a results, the unperturbed molecular dimension, of the PVC-R was dependent on a function of the excluded volume, z, where the z2 coefficient was not zero. The obtained value of the of PVC-R, having a = 87 kDa and = 1.41, was 8.19 × 10−9 (cgs), comparable with the reported value for pure industrial PVCs in THF, 6.4 kDa < < 650 kDa at 25 °C, 8.17 × 10−9 (cgs) and in benzyl alcohol, an ideal solvent, at 155.4 °C, 40 kDa < < 350 kDa, 8.20 × 10−9 (cgs). The comparison of the results showed that the PVC-R had similar characteristics to the industrial PVC reported in the published literature, and hence can be reused as a resin for the manufacturing of PVC commodities.
Bone hydatid disease of distal femur and diaphysis of tibia: report of two cases with review of literature

Cystic echinococcus or hydatidosis is a parasitic infection of humans and animals. In this we are reporting 2 cases. one is hydatid disease at distal femur left side and other patient having hydatid disease at shaft tibia rt side. both cases investigated and definitive surgery was done as arthrodesis with long tibio-femoral nail for distal femoral hydatidosis and curettage for tibial hydatidosis. Both patient given albendazole and followed up. in recent follow-up both cases do not have signs of recurrence. hence case report of these two cases is discussed along with review of literature.
The evaluation of stiffness, distensibility, and strain of the abdominal aorta in asthmatic children

ÖZ Amaç: Bu çalışmada astımlı çocuklarda aterosklerozun tespitinde kullanılabilen aort sertliği, esnekliği ve gerilimi ve bunların kalp fonksiyonları üzerindeki etkisi araştırıldı. Ça­lış­ma­pla­nı:­Ocak 2012 Kasım 2014 tarihleri arasında astımlı toplam 21 çocuk hasta (11 erkek, 10 kız; ort. yaş 11.3±3.2 yıl; dağılım 6-15 yıl) ve 17 sağlıklı çocuk (10 erkek, 7 kız; ort. yaş 12.8±3.8 yıl; dağılım 7-16 yıl) çalışmaya alındı. Abdominal ultrasonografi ile abdominal aortun sertliği, esnekliği ve gerilimi hesaplandı. Tüm çocuklarda ekokardiyografi çekildi.
Variation and correlation of starch potato utility features and tuber quality traits

A b s t r a c t. In the study the authors used data from the Characteristics of the Polish National List of Potato Varieties concerning the economic value and the quality traits of starch potato varieties from the group of very early and early varieties and that of medium late and late varieties. For each of 13 quantitative traits, separately for every group of earliness, the basic statistical measures were determined and the coefficients of simple correlation were calculated, and for the utility traits – the equations of multiple linear regression. It was demonstrated that starch potato varieties were characterised by similar utility traits and variation in the case of dry matter content and starch content, tuber quality traits, i.e. shape and its regularity, and also the depth of the eyes. The late varieties produced a higher tuber yield and, consequently, a higher yield of dry matter, starch yield and bioethanol yield. In addition, a number of positive correlations were shown among the analysed utility traits, especially the tuber yield, with the tuber quality traits, i.e. starch yield, dry matter yield, bioethanol yield, and resistance to virus Y. Negative correlations appeared only in the group of very early and early varieties, between dry matter yield and resistance to virus Y and the content of starch and resistance to common scab. K e y w o r d s: starch potato, earliness group, variety, utility traits, quality traits, variation and correlation of traits
Assessment of self medication practices among medical students in acne vulgaris and patterned baldness in a tertiary care hospital of north India

Objective: To assess the pattern of self medication among medical students in common dermatological conditions like acne vulgarisand patterned baldness. Methods: This was an anonymous, questionnaire-based survey. A self-developed, pre-validated questionnaire was used. The medical and dental students (1 st to 4 th year) who came with the problem of acne vulgaris and patterned baldness in the outpatient of Dermatology department were included in the study. Pattern of self medication for acne vulgaris and patterned baldnessof medical students was recorded for a period of two years starting from March 2013-March2015. Results: Out of the total 472 students, 51.5% were males and 48.5% were females. More than two-third (69.5%) of the students were between 20-21 years of age.Textbooks (32.4%) were the most common source of knowledge. The prevalence of acne vulgaris and patterned baldness was 55.9% and 44.1% respectively. More than half of the students of all years had correct knowledge about topical treatment for acne. Correct knowledge about topical treatment for acne was lower among males (56.8%) than females (58.1%). However, the correct knowledge about oral medicine for acne was higher among males (49.4%) compared to females (47.6%), the difference was statistically insignificant (p>0.05). There was insignificant (p>0.05) difference in the correct knowledge about use of strength of minoxidil lotion for patterned baldness and oral medicine for patterned baldness between male and females. Conclusion: Self-medication for acne vulgaris and patterned baldness was fairly common among medical students. Right knowledge and proper awareness about the medications was lacking in majority of the students and hence appropriate education and guidance is necessary.
Histological changes in the reproductive system of male rats exposed to cigarette smoke or electronic cigarette vapor

Abstract The use of electronic cigarettes increases as a supposedly healthier form of nicotine consumption, but safety of vaping remains uncertain. In this study, we assessed whether the use of electronic cigarettes increases the risk of infertility in male rats. Malformations of sperm morphology were more frequent in nicotine-exposed groups than in the control group. Vacuolization of seminiferous epithelium, reduction of spermatogenesis, increased apoptosis of spermatogonia and spermatocytes, and acceleration of degeneration of testes were observed. The male reproductive organs are slightly less affected by vaping than by smoking. Nevertheless, in consequence both may lead to the reduction of fertility.
Promoting sustainable agricultural management through spatio temporal optimization of food crop land based on pedo-agroclimate at Kalalasi region, Southeast Sulawesi, Indonesia

The purposes of this research were to: (1) analyze the suboptimal land availability and its suitability for food crops; (2) to identify the major and prime food crops; (3) analyze the socio-cultural and economic characteristics of farmers in order to develop local based climate change adaptation strategy and to prioritize major food crops using multi-criteria approach; (4) to promote sustainable crop and land management, through the local specific technologies dealing with the constraints of the Kalalasi Region. As regional based study, this research used overlaid maps of thematic lands, undertaken on suboptimal-land area with dry-climate at Kalalasi Region, Southeast Sulawesi. This study employed a spatial analysis method using GIS. Data collection included data on land biophysics, climate, and farming-based socio-culture and economic, using biophysical and social economic survey method. Land evaluation was carried out using FAO method. The major food crops were identified and analyzed using LQ method. Then, Multi-Criteria Decision Method (MCDM) through an application of AHP was used to promote sustainable crop and land management at the Kalalasi Region. The results of this research showed that: (1) Kalalasi Region had relatively varied characteristics of land biophysic, climate, socio-culture and economic, (2) Potential land availability for the development of food crops was ha, where the land suitability level of S2 (moderately suitable) of ha, S3 (marginally suitable) of ha, and the rest was N1 and N2, (3) there were eight major food crops in the research area, namely: maize, cassava, upland rice, soy bean, sweet potato, ground nut, green bean, and paddy rice, (4) prime or excellent food crops in research area were varied among regions (sub-districts), however, in general, it was concluded that there were four prime food crops, namely: cassava, maize, upland rice, and paddy rice, (5) productive and sustainable crop pattern and land management can be achieved through the application of multiple cropping system, planting diversification, and appropriate planting date for the period of December, January, February, and March, using drought resistant cultivar, and several other efforts for adaptation and conservation, such as mulching and cover crops, to deal with climate change. These were conducted to maintain the land and crop productivity, and the sustainable food availability.
Identifying and managing lupus nephritis during pregnancy

ABSTRACT Introduction: Systemic lupus erythematosus (SLE) is a multi-organ disease that commonly affects women of child bearing-age, and lupus nephritis (LN) represents one of the most severe manifestations. Advances in treatment and better knowledge of the disease have resulted in an increasing number of women seeking pregnancy. Awareness of the relationship of the condition with respect to pregnancy and long-term prognosis is important for all clinicians involved. Presentation of LN can range from mild asymptomatic proteinuria to rapidly progressive renal failure and may occur before, during, or after pregnancy. Areas covered: Here we detail the evolution of maternal disease, obstetrical and neonatal outcomes. We also report a practical approach to managing these pregnancies before, during and after analysing the predictors of poor obstetrical outcome or kidney worsening. Peculiar condition, as with kidney transplanted mothers, the onset of LN during pregnancy, or independent risk factors are also evaluated. Expert opinion: The improvement of LN therapies and better knowledge of the relationship has enormously enhanced the chance of uneventful pregnancies for LN women. A crucial step is to carefully plan the pregnancy with analysis of epidemiological, biological and therapeutic aspects that could interfere with the wellbeing of the mother and the child.
Pengaruh Literasi Keuangan Terhadap Perilaku Pengelolaan Keuangan Mahasiswa

Literasi keuangan merupakan kombinasi dari kesadaran, pengetahuan, keterampilan, sikap dan perilaku yang perlu dimiliki seseorang untuk membuat keputusan keuangan yang sehat dan akhirnya mencapai kesejahteraan keuangan individu. Tujuan dilakukannya penelitian ini adalah untuk mengetahui gambaran literasi keuangan dan perilaku pengelolaan keuangan pada mahasiswa, serta untuk mengetahui pengaruh literasi keuangan terhadap pengelolaan keuangan mahasiswa. Objek dalam penelitian ini adalah 100 orang mahasiswa Fakultas Ekonomi dan Bisnis Universitas Singaperbangsa Karawang. Hasil pengumpulan data melalui kuesioner kemudian diolah dan dianalisis dengan metode statistika regresi linier berganda. Berdasarkan hal tersebut diperoleh hasil bahwa literasi keuangan dengan indikator pengetahuan dasar keuangan pribadi, tabungan dan pinjaman, asuransi dan investasi menunjukkan bahwa pengetahuan dasar keuangan pribadi, tabungan dan pinjaman dan investasi berpengaruh terhadap pengelolaan keuangan mahasiswa, sedangkan asuransi tidak berpengaruh terhadap pengelolaan keuangan mahasiswa. Kata kunci: literasi keuangan, perilaku pengelolaan keuangan, pinjaman dan tabungan, asuransi, investas
Elevated Seismic Hazard in Kansas Due to High‐Volume Injections in Oklahoma

Induced seismicity has expanded into south‐central Kansas, an area with rare damaging natural earthquakes, leading to the second‐highest seismicity rate in the central United States after Oklahoma. Here we assess the mechanical effects of large‐scale injection in the combined area of western Oklahoma and southern Kansas during 2010–2018 and its link to the observed seismicity using physics‐based hydromechanical and seismicity rate models. Such models link injection operations to seismic hazards and allow solving for the spatially variable distribution of background seismic productivity that yields an acceptable match between the observed and modeled seismicity. We show that injection in Oklahoma amplifies the total Coulomb stress change and seismicity rate by 1.5‐fold and threefold, respectively, in south‐central Kansas. This cross‐border interaction modulates the annual earthquake probability in Kansas. We conclude that the issue of induced seismicity is not a local problem due to the far‐reaching effects of fluid diffusion.
How much does Ne vary among species?

Genetic drift is an important evolutionary force of strength inversely proportional to Ne, the effective population size. The impact of drift on genome diversity and evolution is known to vary among species, but quantifying this effect is a difficult task. Here we assess the magnitude of variation in drift power among species of animals via its effect on the mutation load – which implies also inferring the distribution of fitness effects of deleterious mutations (DFE). To this aim, we analyze the non-synonymous (amino-acid changing) and synonymous (amino-acid conservative) allele frequency spectra in a large sample of metazoan species, with a focus on the primates vs. fruit flies contrast. We show that a Gamma model of the DFE is not suitable due to strong differences in estimated shape parameters among taxa, while adding a class of lethal mutations essentially solves the problem. Using the Gamma + lethal model and assuming that the mean deleterious effects of non-synonymous mutations is shared among species, we estimate that the power of drift varies by a factor of at least 500 between large-Ne and small-Ne species of animals, i.e., an order of magnitude more than the among-species variation in genetic diversity. Our results are relevant to Lewontin’s paradox while further questioning the meaning of the Ne parameter in population genomics.
Intraday time‐series momentum: Evidence from China

This study conducts an investigation of intraday time‐series momentum across four Chinese commodity futures contracts: copper, steel, soybean, and soybean meal. Our results indicate that the first half‐hour return positively predicts the last half‐hour return across all four futures. Furthermore, in metals markets, we find that first trading sessions with high volume or volatility are associated with the strongest intraday time‐series momentum dynamics. Based on this, we propose an intraday momentum informed trading strategy that earns a return in excess of standard always long and buy‐and‐hold benchmarks.
Comparative Study of Dry Cord Care versus Application of 5% Povidone-Iodine on Umbilical Cord in Newborns

Introduction: Infections are the most important cause of infant mortality, of which, umbilical cord infections are an important precursor. In developing countries, umbilical cord infections constitute a major source of neonatal morbidity and pose significant risk for mortality. Methods: Prospective analytical study was conducted at KVG Medical College and Hospital, Sullia with an objective to study the aerobic bacteriological profile of umbilical cord in new born and their characterization and to compare two umbilical cord care regimens, that is, dry cord care, and 5% povidone iodine for their impact on colonization and infection. 50 cases, each in category of dry cord care and 5% povidone iodine application on umbilical cord were studied. Results: The study showed that 5% povidone iodine application to the umbilical cord though appeared to reduce colonization with S. aureus, fail to inhibit it completely. Conclusion: Antimicrobial application may enhance colonization with more dangerous multidrug resistant staphylococci (MRSA and MR-CONS). 5% povidone-iodine appeared to be inferior to dry cord care in preventing clinical manifestation in infants.