Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality of Obturation Achieved by Different Endodontic Obturation Systems

Objective: This study was performed to determine in vitro the sealing ability of different endodontic obturation systems and to compare their efficacy. Materials and Methods: In the study were used a total of 36 root canals all of which belong to extracted permanent teeth. Root canals of all samples were prepared with ProTaper Universal rotary files. The teeth were divided into four groups. In each group we had 1 molar with 3 canals, 1 molar with 2 canals, 1 premolar with 1 canal and 3 single-rooted incisors filled by different obturation technique and AH26 sealer. The teeth in the first group were obturated with single-cone technique, in the second group by cold lateral condensation, and the teeth in the third group were obturated with Thermafil. In the fourth group obturation was done with GuttaFlow. After radiography of the root canal fillings, the roots were sectioned horizontally at the level of 2 mm and 4 mm from the apex. The area of gaps and adaptation to canal walls were evaluated using stereomicroscopy and calculated. Results: Evaluation of quality of obturation of root canals based on X-ray examination exhibited compact seal of root canals in all research groups, except with single-cone technique. Evaluation of cross sections revealed that lateral condensation showed the best hermetic sealing and the single-cone technique the worst. GuttaFlow and Thermafil have similar sealing effect. Conclusion: It can be concluded that the density of guttapercha was observed to decrease towards the coronal aspect when the single cone and GuttaFlow were used.
Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial – mesenchymal transition in breast cancer cells via the miR-136 – Smad3 axis

: Circular RNAs (circRNAs) are tissue-speci ﬁ c RNAs with a more stable structure than linear RNAs, and their association with breast cancer (BC) is poorly understood. This study examined the biological effects of circ_0000043 in the progression of BC. In this study, expression of circ_0000043 in BC tissue samples was measured using quantitative real-time polymerase chain reaction. Immunohistochemistry and Western blot were used to detect the expression of Smad family member 3 (Smad3). CCK-8, wound healing, and Transwell assays were used to assess the effect of circ_0000043 on the prolif- eration, migration, and invasiveness of BC cells. Moreover, the binding relationships between circ_0000043 and miR-136, and miR-136 and Smad3 were detected by dual-luciferase reporter assay. Additionally, Western blot was used to detect the expressions of markers related to epithelial – mesenchymal transition, including E-cadherin, N-cadherin, and vimentin. Our results show that the expression of circ_0000043 is up-regulated in BC tissues and cell lines. The proliferation, migration, invasiveness, and epithelial – mesenchymal transition of BC cells were signi ﬁ cantly inhibited by knockdown of circ_0000043, and overexpression of circ_0000043 had the opposite effects. Additionally, circ_0000043 up-regulate the expression of Smad3 by sponging miR-136. In conclusion, our study demonstrates that circ_0000043 promote the progression of BC via regulating the miR-136 – Smad3 axis.
What is on Your Mind ? Motivated Social Inference in Intergroup

The present research examines how people make infer nc s about others’ mental states in intergroup interaction, particularly when they are motivated to get along with an out-group member (i.e., have affiliative motivat ion). Three experiments were designed to examine whether the experience of affil iative motivation influenced the degree to which people infer the mental state of an ther person based on group-based knowledge (e.g., stereotypes) versus self-knowledge (i.e., what the self would do), and whether this relative use of group-based versus self-based inference may depend on the evaluative implications of a given inference strategy. It is hypothesized that because affiliative motivation evokes people’s desi re to see their interaction partner positively, this motivation should encourage the gi ven inference strategy to the extent that the resulting inference is positive in nature. Concomitantly, affiliative motivation should inhibit the inference strategy when the stra tegy implies negative perceptions of the partner. When the predominant inference strate gy is suppressed, people should resort to the other strategy. The examination of m tivated social inference is consistent with growing research interest in how pe opl make inferences in intergroup contexts to better understand the proces s by which people form expectations and behave in intergroup interaction.
Glycerol Oxidation by Fluorinated and Platinized Titania Oxidación de glicerol mediante titania fluorizada y platinizada

In this work, fluorinated and platinized TiO 2 were evaluated in the glycerol oxidation. Fluorination led to increasing the specific surface area of titania, and platinization treatment to obtaining the highest absorption in the visible region of the electromagnetic spectrum; thus, 0.5 wt% Pt-F-TiO 2 was the best catalyst for its highest yield and good selectivity to glyceraldehyde (GAL). It was also found that 2 wt% of Pt content had a detrimental effect on the glycerol conversion. Fluorination and platinum addition led to modify the reaction mechanism and selectivity.
On integrated wheel and track damage prediction using vehicle–track dynamic simulations

The renewal costs for wheels and rails are a substantial part of the costs for rolling stock operators and infrastructure managers all over the world. The causes for reprofiling or grinding are, in most cases, related to the following: (1) wheel or rail profiles with unacceptable wear, (2) appearance of rolling contact fatigue cracks in the surface, and (3) wheel flats caused by locking wheels during braking. The first two causes are related to the dynamic behavior of the vehicle–track system, and can be predicted using multibody simulations. However, there are several limitations that restrain the usefulness of these prediction techniques, such as simulation time constraints, necessary simplifications, and lack of experimental data that lead to educated assumptions. In this paper, we take the end-user perspective in order to show whether the latest developments in wheel–rail damage prediction can be integrated in a simplified framework, and subsequently used by the different stakeholders for an improved management of the different assets involved in the operation of rail vehicles.
Is point wise analysis of the Humphrey visual field feasible as a primary outcome in idiopathic intracranial hypertension?

Purpose Using the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) data, this study aimed to determine if point analysis of the Humphrey visual field (HVF) could be more informative than the perimetric mean deviation (PMD) as an IIH trial outcome measure. Methods IIH:WT was a randomized controlled trial that recruited 66 people with active IIH (mean (standard deviation) age 32 (7.8 years)). Event-based analysis using a pointwise analysis of the numerical sensitivity data was performed. The number of participants that would be eligible for analysis was calculated when the data were enriched to reflect a medically treated cohort defined as a PMD between -2dB to -7dB. Results The HVF 24-2 mean (standard deviation) PMD in the worse eye was -3.5 ( 1.1dB), (range, -2.0 to -6.4dB), and point sensitivity showed a preference for peripheral and blind spot locations. Those points between 0 and -10dB demonstrated negligible ability to improve compared with those between -10dB and -25dB. In evaluating feasibility for a medical intervention trial, 346 points were available for analysis between -10dB and -25dB bilaterally compared with 4123 in baseline sensitivities of 0 to -10dB. Conclusions Mildly affected baseline sensitivities were unlikely to show considerable change over 24 months. There were fewer points available for analysis and greater variability if moderately affected baseline points were chosen. If point analysis was used as an outcome measure in a medical intervention trial, the majority of points would not demonstrate clinically meaningful change, thus offering little advantage over PMD.
Increased ambulance attendances related to suicide and self-injury in response to the pandemic in Australia

Investigating the change in the trend of ambulance service utilization for suicide in response to the COVID-19 pandemic can clarify the impact of the pandemic on acute healthcare services. To determine whether the trends of the ambulance attendances related to self-injury and suicide changes in response to the COVID-19 pandemic. We extracted the data from the National Ambulance Surveillance System in Australia between March 2018 and March 2021 to examine the trajectory of the ambulance attendances related to self-injury and suicide. The results indicate that the number of ambulance attendances related to self-injury, suicidal ideation and suicidal attempt increased immediately during the first quarter since the outbreak and stayed higher over the at least 12 months. Notably, the post-outbreak surge in ambulance attendances associated with these mental health crises did not continue to escalate further. To sum up, the overall increase in ambulance attendances may reflect increased distress in the community, but also signify disruptions of other non-emergency health services. In contrast to recent evidence for the suicide rate being unchanged during the pandemic, our findings provide a different perspective on the impact of the pandemic on mental health services. This warrants a re-assessment of resources for mental health services in the post-COVID era.
Incidence of post-COVID syndrome and associated symptoms in outpatient care in Bavaria, Germany: a retrospective cohort study using routinely collected claims data

Objectives To estimate the treatment incidence of post-COVID syndrome (postinfectious sequelae present at least 12 weeks following infection) in the context of ambulatory care in Bavaria, Germany, and to establish whether related diagnoses occur more frequently than in patients with no known history of COVID-19. Design Retrospective cohort analysis of routinely collected claims data. Setting Ambulatory care in Bavaria, Germany, observed from January 2020 to March 2022 (data accessed May 2022). Participants 391 990 patients with confirmed COVID-19 diagnosis, 62 659 patients with other respiratory infection and a control group of 659 579 patients with no confirmed or suspected diagnosis of COVID-19. Primary and secondary outcome measures Primary outcome is diagnosis of post-COVID syndrome documented in ambulatory care. Secondary outcomes are: chronic fatigue syndrome, psychological disorder, fatigue, mild cognitive impairment, disturbances of taste and smell, dyspnoea, pulmonary embolism and myalgia. Results Among all patients with confirmed COVID-19, 14.2% (95% CI 14.0% to 14.5%) received a diagnosis of a post-COVID syndrome, and 6.7% (95% CI 6.5% to 6.9%) received the diagnosis in at least two quarterly periods during a 2-year follow-up. Compared with patients with other respiratory infections and with controls, patients with COVID-19 more frequently received a variety of diagnoses including chronic fatigue syndrome (1.6% vs 0.6% and 0.3%, respectively), fatigue (13.3% vs 9.2% and 6.0%), dyspnoea (9.9% vs 5.1% and 3.2%) and disturbances of taste and smell (3.2% vs 1.2% and 0.5%). The treatment incidence of post-COVID syndrome was highest among adults aged 40–59 (19.0%) and lowest among children aged below 12 years (2.6%). Conclusions Our results demonstrate a moderately high incidence of post-COVID syndrome 2 years after COVID-19 diagnosis. There is an urgent need to find efficient and effective solutions to help patients with dyspnoea, fatigue, cognitive impairment and loss of smell. Guidelines and treatment algorithms, including referral criteria, and occupational and physical therapy, require prompt and coherent implementation.
From Dark to Light, Ionization and Heat. An Inquiry concerning the Complementary of Dark Matter Electron and Dark Matter Nuclear Scattering

The recent development of direct detection experiments can be divided into two main approaches: On the one hand, to give weakly interacting massive particles (WIMPs) as Elizabeth Gibney puts it "a final chance to reveal itself" [71], on the other hand, to reach out for candidates beyond the WIMP-paradigm. In this regard, new possibilities in the search for dark matter arise by simultaneously lowering detection thresholds successively and exploiting new kinds of atomic or nuclear phenomena besides the well known dark matter nucleus scattering, namely dark matter electron scattering, the Migdal effect or Bremsstrahlung. While the interaction of dark matter particles and target materials differs for each effect, the observable quantity for each of these phenomena ultimately is the energy deposited in the detector. For dark matter nucleus scattering, some of the kinetic energy of a dark matter particle is transferred to the nucleus of a Standard Model particle. This energy deposition is then converted to measurable signals i.e. ionization, scintillation light or heat. The Migdal effect on the other hand induces ionization signals in addition to the nuclear recoil (3-body process), when a sub-GeV dark matter particle scatters off the nucleus. Finally, when dark matter couples directly to electrons (i. e. electron scattering), ionization and excitation in the electron system of the target atoms can be detected. This means that, depending on the dark matter mass and its coupling to the Standard Model particles, a variety of detection avenues exist at direct detection experiments. The deposited energy of dark matter particles within the detector can mainly (with the exeption of bubble chambers) be measured via scintillation, ionization or heat. Understanding the limits of each effect therefore becomes a key aspect of exploiting the complete potential of current and future direct detection experiments. This is especially the case for dark matter scenarios that go beyond the WIMP paradigm by involving e.g. multiple components. This thesis addresses a comprehensive analysis of the above described dominating theoretical effects induced by dark matter interaction with the Standard Model constituents, primarily taking liquid Xenon as an example. In order to achieve this, the astrophysical parameters, the possible ways of interaction and the detector response for each interaction need to be computed. This results in anticipated interaction rates for each effect and detector. Comparing these anticipated detection rates allows us to draw conclusions for possible blind spots and challenges in setting direct detection limits for particular dark matter scenarios.
Model Persamaan Struktural Pengaruh Budaya Keselamatan Kerja pada Perilaku Pekerja di Proyek Konstruksi

Abstrak . Budaya keselamatan kerja memegang peranan sangat penting dalam membentuk perilaku pekerja pada proyek konstruksi. Dengan demikian usaha untuk mengurangi kecelakan kerja di konstruksi harus dimulai dengan membentuk budaya keselamatan kerja yang baik. Namun, studi mengenai budaya keselamatan kerja serta pengaruhnya kepada perilaku pekerja masih sangat jarang di konstruksi. Penelitian ini ditujukan untuk mengetahui secara empiris pengaruh budaya keselamatan kerja pada perilaku pekerja. Untuk mencapai tujuan ini, pertama-tama diusulkan suatu model yang terdiri dari enam faktor budaya keselamatan kerja dan satu faktor perilaku pekerja. Model ini kemudian diuji dengan metode model persamaan struktural (structural equation modeling). Data diperoleh dengan cara menyebarkan kuesioner kepada pekerja. Dua ratus tujuh set kuesioner berhasil dikumpulkan dan digunakan untuk menganalisa model yang diusulkan. Hasil analisis model persamaan struktural menunjukkan hanya empat faktor budaya keselamatan kerja yang memberikan pengaruh secara signifikan pada perilaku pekerja. Makalah ini menyimpulkan bahwa: (i) komitmen pihak manajemen merupakan penggerak utama dari budaya keselamatan kerja, dan (ii) perilaku pekerja dapat dikendalikan melalui kombinasi pendekatan prescriptive dan discretionary. Abstract . Safety culture plays a very important role in shaping workers’ safety behavior in construction project. Therefore efforts to minimize construction accidents should first be started by performing good safety culture. However, existing empirical attempts to study safety culture and its influence to worker behavior in construction are still in their infancy stage. This research examines empirically the influence of organizational safety culture on workers behavior. To accomplish this objective, the research first proposed a hypothetical model, which comprised of six factors of organizational culture and one factor of worker behavior. This model was then evaluated statistically through structural equation model. Data needed were collected by conducting questionnaire survey to construction workers. A total of 207 valid questionnaires were returned and formed the basis for structural equation modeling and subsequent analyses. The analyses results indicate only four safety culture factors having significant influence on workers behavior. The research concludes that top management commitment is a pivotal driver of safety culture, and the workers behavior can be controlled using the combination of prescriptive and discretionary approaches.
Expression of (cid:1) -Crystallin in Retinoblastoma

Objective : To examine the expression of (cid:1) -crystallin, a small heat-shock protein family, and apoptosis in retinal neoplastic cells. Methods : Thirteen enucleated globes were included in this study, 1 with retinocytoma and 12 with retinoblastoma. Formalin-fixed paraffin-embedded tissue sections were processed for immunohistochemistry with (cid:1) crystallin antibodies. Apoptotic cells were detected using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) method. Results : In the retinocytoma, (cid:1) A-crystallin was expressed in the cytoplasm of all tumor cells, whereas (cid:1) B-crystallin immunoreactivity was only weakly positive. Apoptotic cells were rarely noted in retinocytoma cells; the apoptotic index was 0.29. Examination of the retinoblastoma globes revealed 6 cases (50%) that were strongly positive for (cid:1) A-crystallin. The mean (SD) apoptotic indices in the strongly and weakly positive cases were 3.55(2.61) and 7.50(2.61), respectively. The apoptotic index was significantly higher in those cases that were weakly positive for (cid:1) A-crystallin than in those that were strongly positive ( P (cid:2) . 05). No correlation was observed between apoptotic index and (cid:1) B-crystallin immunoreactivity, although 50% of retinoblastomas were strongly positive for (cid:1) B-crystallin. Conclusions : The (cid:1) A- and (cid:1) B-crystallins are expressed in retinoblastomas, and (cid:1) A-crystallin expression may prevent apoptosis 20% fetal bovine serum. The Y79 cells were treated with dif- ferentconcentrationsofH 2 O 2 (range,0µMto400µM)for24hours. The cells were then harvested and protein was extracted.
Surveys in Contemporary Mathematics: Cohomology of face rings, and torus actions

In this survey article we present several new developments of `toric topology' concerning the cohomology of face rings (also known as Stanley-Reisner algebras). We prove that the integral cohomology algebra of the moment-angle complex Z_K (equivalently, of the complement U(K) of the coordinate subspace arrangement) determined by a simplicial complex K is isomorphic to the Tor-algebra of the face ring of K. Then we analyse Massey products and formality of this algebra by using a generalisation of Hochster's theorem. We also review several related combinatorial results and problems.
Possible Involvementof Ca2+Mobilization and Protein Kinase C Activation in the Induction of Spontaneous Metastasis by Mouse Mammary Adenocarcinoma Cells1

Evidence is provided to show that two secondary cell-signaling path ways, Ca2* mobilization and the activation of protein kinase C (PKC), are involved in the induction of spontaneous metastasis in mouse adenocarcinoma cell line SP1. Unlike the parental cells, which were found to be tumorigenic but unable to metastasize from a s.c. site, SP1 cells treated with ionophore A23187 (to mobilize Ca2*) or phorbol 12-myris-tate 13-acetate (to activate PKC) were able to metastasize spontaneously. Analysis of SP1 cells treated with either agent separately or with both agents simultaneously revealed that both pathways contributed to the final response in a separate and nonsynergistic way. The induced metastatic phenotype in most cases appeared to be heritable. Examination of Ca2+ sources during cell activation by ionophore A23187 suggested that internal ( 'a'* was sufficient for the process of induction. Examination of PKC activity and its intracellular distribution during and after treat ment of SP1 cells with ionophore A23187 and phorbol 12-myristate 13-acetate were also evaluated. The results suggested that the basal levels of PKC and the activation of the enzyme appear to be involved in the induction of spontaneous metastasis. Taken together, these observations are consistent with the hypothesis that cell-signaling pathways exist which can induce the metastatic phenotype and that this may be related to phosphatidylinositol turnover.
Investigation of Vector-Borne Diseases in Dogs

: In this study, a total of 186 blood samples were collected from kennel dogs consisting of 104 male and 82 female in five provinces (Mersin, Adana, Hatay, Gaziantep and Batman) of Turkey, and evaluated using molecular methods for the presence of canine vector-borne diseases (CVBDs). Overall, 10.8% of the sampled dogs were found to be infected with one or more CVBD pathogens investigated. Ehrlichia canis (17/186; 9.1%) was the most common CVBD pathogen, followed by Babesia canis vogeli (5/186; 2.7%) and Hepatozoon canis (1/186; 0.5%), respectively. Co-infection of E. canis with B. canis was detected in 3 (1.6%) dogs. Infection with Rickettsia spp. , Coxiella burnetii , Borrelia burgdorferi s.l. , Francisella tularensis , Bartonella spp. , Leishmania spp. , Diroflaria immitis , Diroflaria repens , and Acanthocheilonema reconditum were not detected. No sex association with CVBDs was determined (p>0.05). The result of the study indicates the presence of three CVB pathogens, including the first report of B. canis and H. canis in the studied provinces.
RETROSPECTIVE ANALYSIS OF INCIDENCE AND OUTCOME OF PERIPARTUM CARDIOMYOPATHY PATIENTS IN EMERGENCY OBSTERTIC CASES IN RURAL TERTIARY CARE HOSPITAL

Peri -partum cardiomyopathy is an idiopathic and reversible form of dilated cardiomyopathy . It is life threatening but potentially treatable heart failure affecting women during peripartum period. The aim of the study was to determine the incidence and outcome of peripartum cardiomyopathy(PPCM) patients in emergency obstetric cases over one and half year period in our college hospital. It is a retrospective observational study in emergency obstetric patient with total of 16 patients with PPCM was diagnosed in total of 10560 deliveries conducted at Government Theni Medical College Hospital between January 2017-July2018. Most of the patients are young with mean age of27.3±4.29 years ,with multigravida(62.5%). Many of them were diagnosed in postpartum period(75%). The most common risk factor was pre eclamsia(37.5%). The mean ejection fraction was found to be 30.93±7.4%. There were two maternal mortality (12.5%) and two cases refered to GRH Madurai(12.5%). Women presenting with heart failure during peripartum period should be evaluated for PPCM. Early detection and perfect management of cardiac failure provides a better prognosis.