Miracle-dz/UniFAR-FTUs huggingface dataset:
The Cannabinoid Receptor 2 Is Critical for the Host Response to Sepsis 1

Leukocyte function can be modulated through the cannabinoid receptor 2 (CB2R). Using a cecal ligation and puncture (CLP) model of sepsis, we examined the role of the CB2R during the immune response to an overwhelming infection. CB2R-knock out (KO) mice showed decreased survival as compared with wild-type mice. CB2R-KO mice also had increased serum IL-6 and bacteremia. Twenty-four hours after CLP, the CB2R-deﬁcient mice had increased lung injury. Additionally, CB2R-deﬁciency led to increased neutrophil recruitment, decreased neutrophil activation, and decreased p38 activity at the site of infection. Consistent with a novel role for CB2R in sepsis, CB2R-agonist treatment in wild-type mice increased the mean survival time in response to CLP. Treatment with CB2R-agonist also decreased serum IL-6 levels, bacteremia, and damage to the lungs compared with vehicle-treated mice. Finally, the CB2R agonist decreased neutrophil recruitment, while increasing neutrophil activation and p38 activity at the site of infection compared with vehicle-treated mice. These data suggest that CB2R is a critical regulator of the immune response to sepsis and may be a novel therapeutic target. The Journal of Immunology, 2009, 183: 499–505.
Source Geometry and Causes of the 2019 Ms6.0 Changning Earthquake in Sichuan, China Based on InSAR

On 17 June 2019, an Ms6.0 earthquake occurred in Changning, Sichuan, China (Changning event), which was the largest earthquake on record within 50 km of the area. It attracted great attention as the area has the largest shale gas production in China as well as significant mineral salt production. Using the Interferometric Synthetic Aperture Radar (InSAR), we extract the coseismic deformation of the Changning event and two earlier Ms > 5.0 earthquakes which occurred in the same region (16 December 2018 Ms5.7 and 3 January 2019 Ms5.3) from the Sentinel-1 and ALOS2 data. We use nonlinear and linear methods to invert the fault models of the three earthquakes based on the deformation fields. The final model shows that the Changning event was caused by a fault with left-lateral strike and thrust slip. The strike is 124.3° with a dip angle of 43.4°. The seismic moment obtained by inversion is 5.28 × 1017 Nm, corresponding to Mw 5.78. Based on the fault models, we analyze the cause of the Changning earthquake considering the local tectonic setting, Coulomb stress change, mining, and fluid injection. We consider that the event may be related to salt mining. The two earlier Ms > 5.0 earthquakes may also play an important role in advancing the Changning earthquake.
A comparative work on vibration control of a quarter car suspension system with two different magneto-rheological dampers

This work compares the ride comfort of a passenger vehicle whose suspension system is equipped with two different magneto-rheological (MR) dampers: with and without bypass holes in the piston. In order to achieve this goal, two cylindrical type MR dampers, which otherwise have the same such geometrical dimensions as radius of piston, length of pole and distance between two poles, are designed based on a mathematical model and subsequently manufactured. One of MR dampers is then modified by making bypass holes in the piston bobbin structure to obtain a relatively low slope of damping force in the pre-yield region. The field-dependent damping force characteristics are investigated through both simulation and experiment. After characterizing the field-dependent damping force of the two MR dampers, a quarter car model is established to evaluate the ride comfort. In this work, a simple but very effective sky-hook controller is adopted, and vibration control performance is evaluated under two road profiles: bump and random road excitations. It is demonstrated through simulation and experiment that the MR damper with bypass holes provides better ride comfort to the car so equipped than that without.
THE STABILITY THRESHOLD AND DIOPHANTINE APPROXIMATION

The purpose of this paper is to use the ﬁltration that appeared in Ru and Vojta [Amer. J. Math. 142 (2020), pp. 957-991] to extend the result of Blum-Jonsson [Adv. Math. 365 (2020), p. 57], as well as to explore some connections between the notion of the K -stability and Diophantine approximation, especially the β -constant and the Ru-Vojta’s theorem.
Design proposal of a wireless sensor and actuator network for irrigation, based on Internet of Things technology

Objective: This paper presents a detailed selection of IoT technologies for the design of an ambient humidity monitoring infrastructure to control crop irrigation. Methodology: The prototype design was supported by previous studies carried out by the authors and tests in 2019 at Finca el Porvenir in Cundinamarca, Colombia, in order to determine the best option to implement in the field through the use of Python software, and elements such as Raspberry Pi and the TTGO development board. Results: To determine the functionality of the software and hardware of the system, different static tests of the prototype were carried out by monitoring humidity and ambient temperature by means of the DHT22 sensor, whose information is sent from a transmitter node to a receiver node in a concentrator to later save the information in a database and, finally, to obtain graphs of the behavior of the relative humidity, temperature, and the actuation of the control element (solenoid valve). Conclusions: With this information it is possible to demonstrate the effectiveness of the prototype, the possibility of remote connection with the LoRa protocol and the handling and management of information from different crop areas through the GUI on the Raspberry Pi, generating a low-cost solution for access by small and medium producers in rural areas in Colombia.
How UK HE STEM Students Were Motivated to Switch Their Cameras on: A Study of the Development of Compassionate Communications in Task-focused Online Group Meetings

HE’s pandemic-driven shift to online platforms has increased social and learning disconnection amongst students. In online group work/teamwork, many are reluctant to switch on their cameras to be more present to others. Compassion in group work/teamwork is defined as noticing, not normalizing, one’s own and/or others’ distress or disadvantaging and taking wise action to prevent or reduce this. This notion of compassion is being assessed in the HE sector using filmed task-focused in-class group work meetings to identify levels of both inclusivity and criticality around the team. This study investigates the use and outcomes of using the compassionate communications strategies (that were developed in and for the offline classroom) in online team meetings. In this mixed-methods study, two groups of four international STEM students, each from a sample of five UK universities, were video-recorded in task-focused group work meetings (TGMs) before and after an online interactive 90-min training session (‘the intervention’) on the Cognitive Skills of Compassionate Communications (CSCC) in teams. A comparison of the (pre and post CSCC intervention) quantitative and qualitative data results indicated, post-intervention, a significant increase in students’ screen gaze attentiveness to each other, and reasons why students’ motivation to switch on their cameras had changed.
Discovering How to Get Engineering on the Radar of Community College Students

It is well-known that community colleges (CCs) are a largely unexploited resource for more engineers and computer scientists in the United States. It is also well-known that many of these students do not have engineering as a career on their radar because they know little or nothing about engineering. In Fall 2014 on a visit to a nonmetropolitan CC, two engineering professors visited nine classrooms and talked with over 165 students. At the beginning of the presentation the students were surveyed for their opinions on engineering including their interest, their knowledge of engineering, and their myths about engineering. This paper shows the results of the survey and, in particular, examines the results by whether or not a student is interested in engineering or computer science as a career. An emphasis in our work has been to encourage females and underrepresented minority students to consider engineering. The CC we visited has a high Hispanic population. By analyzing these results, we will be better able to focus future presentations to these populations of students.
OTT_A_283891 497..507

Bladder cancer is a common urinary tract cancer with a difficult clinical course. With frequent recurrence, patients with a history of bladder cancer often undergo surveillance that involves invasive cystoscopies and biopsies. Not only is this financially burdensome for patients but it is also mentally and physically intensive. Given this predicament, the field has shifted towards the use of non-invasive urinary tests to detect bladder cancer earlier in the disease course and to avoid unnecessary procedures. The first noninvasive test developed was urine cytology; however, that was found to have a low sensitivity, especially for low-grade lesions. There are many tests that are available that utilize common protein biomarkers to enhance the sensitivity of detection. However, many of these tests lack the specificity seen with cytology. With recent technological and research advancements, there are newer detection systems such as RNA sequencing and microfluidics along with novel bladder cancer biomarkers including mRNAs, methylation patterns and exosomes, which have potential to be used in clinical practice. The aim of this review is to highlight established non-invasive bladder cancer diagnostic tests as well as innovative methodologies that are on the horizon for use in bladder cancer detection.
Development of a novel multi-level hybrid methodology for a new concept of Wave Energy Converter (WEC)

Successful WEC design and development needs massive experimental and in-field studies to cover different aspects of hydro-servo-elastic-geo interaction. Consequently, the lack of fairly accurate modeling methodology has inevitable effects on developing cost-effective harnessing technologies. Through this paper, a novel multi-level methodology combining experimental and numerical simulation is presented for a new WEC concept which significantly decreases the time-consuming process of concept validation. The methodology is comprised of multi-level numerical and experimental studies that are developed for reliable while the fast representation of a WEC device. The methodology can be easily tailored and adapted for different phases of analysis and design of any type of hybrid concept or single WEC devices. The proposed modelling methodology is hybrid multi-level experimental numerical simulations and is developed based on lessons learned and the expected challenges in representing a device. The proposed methodology has the advantage of easily being adapted for the fast-paced industry environment. The case study WEC device is also a new concept inspired by nature and in its first levels of concept validation. This concept is expected to operate efficiently even in areas with less energetic waves. The primary shape of the moving part of the device is inspired by nature to overcome resistance forces and increase the penetration and motion in water. The shape is also further improved considering manufacturing possibilities and the required symmetry for the device operation in the real sea. The corresponding numerical results are also presented along with a novel systematic modeling methodology to show the efficiency of the methodology in the development process of WEC. methodology its early stage of methodology and The goal is to speed up the of understanding the device with multi-level modeling techniques. It allows to be tailored based on the information required to be obtained. The results confirm that the methodology is successful in improving the drag resistancy of the device with advanced Micro modeling and improving its hydrodynamic efficiency with Macro-modeling. It was shown that the tuned system doesn't need to imply the PTO stiffness, while untuned system needs almost 40% of the hydrostatic stiffness to reach the same efficiency. The proposed methodology will be used for the future development of this WEC with the combination of more advanced experimental tests.
SUBJECTIVE WELL-BEING (HAPPINESS)

Course Objective Learning Objectives The purpose of this course is to provide an Upon completion, the participant will be able to: understanding of the concept of happiness, 1. Describe major components and specific entitled “subjective well-being” within elements of happiness. psychological literature. Major topics include 2. Discuss demographic effects, such as sex, the demographic correlates of happiness, age, income, education, etc., upon associated traits, the effect of personality and subjective well-being. temperament, and theories explaining personality’s 3. Acknowledge environmental effects influence on happiness. including marriage, job satisfaction, health, leisure, competencies, etc., upon happiness. Accreditation 4. Understand causes, predictors, and Provider approved by the California Board of correlates of happiness, and accompanying Registered Nursing, Provider # CEP 14008, for 7.2 theoretical justification. Contact Hours. 5. Explain key personality traits which In accordance with the California Code of promote greater well-being, such as Regulations, Section 2540.2(b) for licensed extroversion, optimism, self-esteem, etc. vocational nurses and 2592.2(b) for psychiatric 6. Determine personality and temperament technicians, this course is accepted by the Board of effects upon happiness. Vocational Nursing and Psychiatric Technicians for 7. Discuss the relationship between 7.2 contact hours of continuing education credit. personality and happiness.
The impact of patient-centered care on health outcomes in adolescents living with diabetes

There is increasing evidence from research studies that suggest patient-centered care has a relationship with good clinical outcomes. In Singapore, there are no studies done to assess and address the issue of patient-centered care and its association with the adolescent’s ability to manage their chronic medical condition, such as Type 1 Diabetes Mellitus. The relationship between the patient and clinicians has changed from a paternalistic form to a position which aims to foster patient- centered care. More importantly, this study aims to show the adolescent’s readiness and ability to assume a more mature role in management of their own medical condition. Data collection involved 85 adolescents with diabetes who were surveyed during their follow- up outpatient clinic visit at KK Women’s and Children’s Hospital (KKH) Diabetes Transition Clinic. The study offers important clinical and nursing implications as well as policy contributions. Improved patient – provider communication as well as high quality discharge, care transition and emotional support from providers fostered by patient-centered care are likely to contribute to better patient reported psychosocial health outcomes. These findings imply that public healthcare leaders have to place emphasis in the patient and their families’ experience equivalent to those in patient safety,
Effective, efficient and reliable postcode alternative system in the context of online shopping for solving the problem of home delivery service in Jordan

The home delivery service is considered as the bottleneck of online shopping and plays an important role in the success of such business application. A lack of postcode system in the developing countries, Jordan specifically, is one of the main challenges that face delivery couriers and e-retailers. The main aim of this PhD project reported in this thesis is the development of a novel postcode alternative system to enable online shopping and home delivery service of purchased goods in Jordan. The system incorporates two modules: the front-end and the back-end module. The front-end module is combined of two platforms: desktop and smart phone platforms and can be used by online shoppers; the back-end module is designed to be used by retailer/delivery courier as the system administrator. Two studies were conducted in this research; the first study was aiming to understand the problems that face e-consumers when shopping online and the work behaviour of the delivery system in Jordan. Whilst; the second study was aiming to evaluate usability of the designed system. Data was collected by conducting an experimental sessions and distributing questionnaires among three samples of people (consumers, retailers, and delivery couriers). The findings of these studies showed that there was a concern from consumers-side in describing their delivery address to the retailer/delivery courier. In addition, there was a concern from retailers and delivery couriers-side in finding the delivery address location. Furthermore, a user testing was conducted on both modules by involving a number of participants according to the relevance of their use of the system to evaluate the usability of the system. In the evaluation, it was demonstrated that the system makes an important contribution for solving the problem of home delivery service and improving online shopping in Jordan.
Evaluating Quality of Higher Education by Assessing its Output The Swedish Example

Purpose: The purpose of this study is to describe experiences of evaluating quality of higher education based on indicators of output indicators rather than process indicators as main basis for assessment. Methodology/Approach: Deriving from previous experiences this observational study addresses the method for governmental evaluation of quality in Swedish higher education which has recently been fundamentally changed. A previously broad approach including measurement of various process indicators was replaced by a strict focus on output, mainly in terms of to what degree student theses fulfil stated overall aims of the education program or subject area at hand. The new assessment is mainly performed by a second set of teachers from other universities evaluating a random sample of the students’ final theses of a given university program. This paper examines the new evaluation approach from a qualitative perspective of its review process. Findings: The new method has been controversial, receiving criticism from several directions. In 2012, the European Organisation for Quality Assurance in Higher Education criticized the new system for, among other things, not being directed toward improving the education but rather to rank programs or to punish programs of low quality. However, much of the critique has been based on theoretical reasoning regarding how the assessment was to be performed, rather than on measurements of actual performance or outcome. Different problems regarding reliability and validity in the review process are discussed, including issues related to consensus meetings, sample sizes, university self-assessment, and of the ranking, reprisal and improvement components of the evaluation results. Research limitations/implications: There is a need to further study the reliability of the university program assessment process, and the individual thesis assessments in particular. The validity of the assessment method, primarily focusing on externar reviewers of approved theses, is also questionable and in need of further studies. Focus The focus of the assessment in is now on controlling that the learning goals of set by the Swedish higher Higher education Education act Act are implemented. Our Besides reliability and validity concerns, our contention is that more emphasis should also be put on the perspectives of other stakeholders. Originality/Value of paper: Given the importance of an inadequate quality statement and how that would reflect the overall ranking of the program, especially for many small programs, this study argues the importance of developinggives empirical support for many of the the flaws highlighted in the published critiques of the assessment system that primarily were of Ändrad fältkod conceptual or theoretical nature, based on how the assessment was thought to be performed rather than how the assessment did work once implemented.
The impact of the COVID‐19 school closures on families with children with disabilities: A qualitative analysis

Abstract The unprecedented school closures in response to COVID‐19 have been associated with a number of negative impacts on students and their families. In addition to these difficulties, parents of students with disabilities are faced with prepandemic stresses and challenges that may be exacerbated by the school closures. This qualitative study aimed to investigate the experiences and struggles of parents of children identified with a disability during the COVID‐19 school closures. The 15 participants were parents of children with a range of disabilities, including Autism, Down Syndrome, ADHD, and learning disabilities. The analyses revealed four major themes: school connection, virtual learning, potential impacts for students, and managing change. The experiences of these caregivers during the COVID‐19 school closures and subsequent shift to remote learning have implications for educational and treatment planning. Recommendations for how school psychologists and school teams may best support students with disabilities and their families are included.
Study and design of a pico-hydropower plant for academic education and research use

Installing various didactic prototypes in universities is a suitable way that facilitates learning. These prototypes affect positively students' attention and help them to focus in class. In general, the students are mechanically inclined, so they are more interested to deal with hands-on experiments than to pore over theoretical analysis. For these raisons, a pico-hydropower plant (PHPP) prototype was developed and installed in our department. This paper describes the developed prototype which could be used for teaching the hydroelectric conversion, the PHPP operation principle and the control and the stability of a mini grid. In addition, using the prototype, students could validate the studied regulation techniques, they will also master various skills deemed necessary and proper for them to achieve success in different electrical engineering disciplines. Further, the prototype could be used in research to develop new advanced control laws.
Anthropogenic emission is the main contributor to the rise of atmospheric methane during 1993–2017

Abstract Atmospheric methane (CH4) concentrations have shown a puzzling resumption in growth since 2007 following a period of stabilization from 2000 to 2006. Multiple hypotheses have been proposed to explain the temporal variations in CH4 growth, and attribute the rise of atmospheric CH4 either to increases in emissions from fossil fuel activities, agriculture and natural wetlands, or to a decrease in the atmospheric chemical sink. Here, we use a comprehensive ensemble of CH4 source estimates and isotopic δ13C-CH4 source signature data to show that the resumption of CH4 growth is most likely due to increased anthropogenic emissions. Our emission scenarios that have the fewest biases with respect to isotopic composition suggest that the agriculture, landfill and waste sectors were responsible for 53 ± 13% of the renewed growth over the period 2007–2017 compared to 2000–2006; industrial fossil fuel sources explained an additional 34 ± 24%, and wetland sources contributed the least at 13 ± 9%. The hypothesis that a large increase in emissions from natural wetlands drove the decrease in atmospheric δ13C-CH4 values cannot be reconciled with current process-based wetland CH4 models. This finding suggests the need for increased wetland measurements to better understand the contemporary and future role of wetlands in the rise of atmospheric methane and climate feedback. Our findings highlight the predominant role of anthropogenic activities in driving the growth of atmospheric CH4 concentrations.