Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance differences between aphasia and healthy aging on an executive function test battery

Abstract Purpose: Executive function (EF) deficits commonly co-occur with other linguistic and non-linguistic deficits in aphasia. The questions about whether, and to what extent, people with aphasia (PWA) present deficits on different executive functions (EFs) is relatively understudied. Method: In this study, four EFs, set-switching, updating, inhibition, and dual task processing were evaluated in aphasia and healthy groups. Three groups of participants: 30 healthy young, 30 healthy old, and 10 PWA were assessed on four tasks, Colour Trails Test (CTT 1 and 2), Conners’ Continuous Performance Test II (CPT II), n-back (1- and 2-back), and divided attention task that tapped into different EFs. In order to examine performance differences on the EF tasks between the participant groups, repeated measures and multivariate analysis of variances with follow-up pairwise comparisons were computed. Pearson product-moment correlations were conducted to evaluate the strength and direction of the association between aphasia severity (on Western Aphasia Battery-Revised) and executive functioning. Result: PWA demonstrated significantly diminished performance on all EF tasks in comparison to healthy groups and differences were distinct on the higher-level complexity tasks such as the 2-back and CTT 2. The healthy older group demonstrated elevated response times on the CTT, CPT II, and divided attention tasks, and decreased sensitivity scores on the CPT II and n-back in comparison to the younger group. Also, aphasia severity correlated with reduced performance on selective EF measures. Conclusion: This study emphasises the importance of investigating EF deficits in PWA and its potential relationship to language behaviour. Understanding EF is critical for comprehension of linguistic and non-linguistic deficits and in planning treatment for PWA.
Robust Ag/ZrO2/WS2/Pt Memristor for Neuromorphic Computing.

The development of the information age has made Resistive Random Access Memory (RRAM) a critical nanoscale memristor device (MD). However, due to the randomness of the area formed by the conductive filaments (CFs), the RRAM MD still suffers from a problem of insufficient reliability. In this study, the memristor of Ag/ZrO2/WS2/Pt structure is proposed for the first time, and a layer of two-dimensional (2D) WS2 nanosheets was inserted into the MD to form 2D material and oxide double layer MD (2DOMD) to improve the reliability of single-layer devices. The results indicate that the electrochemical metallization memory cell exhibits a highly stable memristive switching and concentrated ON- and OFF-state voltage distribution, high speed (∼10 ns), and robust endurance (>109 cycles). This result is superior to MDs with a single-layer ZrO2 or WS2 film, because two layers have different ion transport rates, thereby limiting the rupture/rejuvenation of CFs to the bilayer interface region, which can greatly reduce the randomness of CFs in MDs. Moreover, we used the handwritten recognition dataset (i.e., the Modified National Institute of Standards and Technology (MNIST) database) for neuromorphic simulations. Furthermore, bio-synaptic functions and plasticity, including spike-timing-dependent plasticity and paired-pulse facilitation, have been successfully achieved. By incorporating 2D materials and oxides into a double-layer MD, the practical application of RRAM MD can be significantly enhanced to facilitate the development of artificial synapses for brain-enhanced computing systems in the future.
Latest Developments in Normal-Pressure Glaucoma: Diagnosis, Epidemiology, Genetics, Etiology, Causes and Mechanisms to Management

Abstract Normal-pressure glaucoma (NPG) is part of the spectrum of the open-angle glaucomas and morphologically characterized, as any glaucoma, by a loss of neuroretinal rim parallel to an enlargement and deepening of the optic cup, and development or enlargement of parapapillary beta zone. These morphological characteristics, in addition to the therapeutic benefit of lowering the intraocular pressure (IOP), make NPG differ from vascular-induced optic neuropathy. Based on the anatomy of the optic nerve as a cerebral fascicle, the physiological counter-pressure against the IOP is the orbital cerebrospinal fluid pressure (CSFP), with both pressures forming the trans-lamina cribrosa pressure difference (TLCPD). In contrast to the IOP, the TLCPD is the true pressure exerting force on the optic nerve fibers when passing through the lamina cribrosa. As a theoretical notion, an abnormally high TLCPD due to a low CSFP, in association with a low arterial blood pressure, could therefore be involved in the pathogenesis of NPG. It fits with the finding that the reduction of the IOP (and thus indirectly of the TLCPD) is (the only proven) procedure for NPG therapy. This review additionally highlights the genetic background, diagnostic methods, and therapeutic modalities of NPG.
Protective effects of enzyme degradation extract from Porphyra yezoensis against oxidative stress and brain injury in d-galactose-induced ageing mice

Abstract The present study investigated the effects of Porphyra yezoensis enzyme degradation extract (PYEDE) on the brain injuries and neurodegenerative diseases due to oxidative stress. We used in vitro antioxidant systems to verify the antioxidant potential of PYEDE. The results indicated that the PYEDE alleviated weight loss and organ atrophy, reduced the levels of lipid peroxidation and protein carbonylation and elevated reduced glutathione (GSH) content in the serum and brains of the d-galactose-induced ageing model mice. The PYEDE also renewed the glutathione peroxidase (GSH-Px), superoxide dismutase and total antioxidant capability activities, down-regulated the inducible nitric oxide synthase activity and nitric oxide levels, normalised the hippocampal neurons and modulated multiple neurotransmitter systems by inhibiting the activities of acetylcholinesterase and monoamine oxidase in the up-regulation of acetylcholine, dopamine and noradrenaline levels. Overall, the PYEDE is a promising supplement for the alleviation of oxidative stress and age-associated brain diseases.
Relationship between thrust, anthropometrics, and dry-land strength in a national junior swimming team

ABSTRACT Objectives: This study aimed to (i) assess an anthropometric and thrust inter-limb asymmetry, and; (ii) determine the contribution of anthropometrics, and dry-land upper-body strength and power to the thrust of talented adolescent swimmers. Methods: Eighteen talented adolescent swimmers (12 boys and 6 girls: 15.81 ± 1.62 years old) were evaluated. A set of anthropometric, dry-land upper-body strength and power, and in-water thrust were assessed. Results: Despite the fact that the dominant side presented higher values in anthropometrics (except for the hand surface area) and thrust, non-significant inter-limb differences were found. The symmetry index indicated a symmetry between upper-limbs. Hierarchical linear modeling retained as main predictors of each upper-limb thrust the respective hand surface area (dominant upper limb: estimate = 0.293, 95CI: 0.117; 0.469, p = 0.005; non-dominant upper limb: estimate = 0.295, 95CI: 0.063; 0.526, p = 0.025). The full stroke cycle retained the upper-body dry-land strength as main predictor (estimate = 0.397, 95CI: 0.189; 0.605, p = 0.002). Conclusion: The hand surface area and upper-body strength were the main predictors of each upper-limb and full stroke cycle thrust, respectively. Hence, coaches and practitioners should aim to carefully maximize the hand surface area (by finger spreading) while performing the stroke, as well as dry-land upper-body strength in order to enhance the performance.
Sex Differences in the Association Between Frailty and Sarcopenia in Patients With Cirrhosis

OBJECTIVES: Frailty is prevalent in patients with cirrhosis and is hypothesized to result in part from sarcopenia, but the precise contribution of sarcopenia to frailty in this population is poorly understood. METHODS: Included were patients with cirrhosis from 2011 to 2014 who had an ambulatory frailty assessment and abdominal computed tomography scan within 3 months. Logistic regression assessed the associations between frailty (=Liver Frailty Index ≥4.5), and sarcopenia (=skeletal muscle index of <39 cm2/m2 for women and <50 cm2/m2 for men). RESULTS: Two hundred ninety-one participants were included: 33% were female. The median (interquartile range) Liver Frailty Index was 3.7 (3.3–4.2); 19% were frail. The median (interquartile range) skeletal muscle index was 49 cm2/m2 (31–69); 36% had sarcopenia. Among the 54 frail participants, 48% had sarcopenia. In univariable logistic regression, sarcopenia was associated with a 1.86× increased odds of being frail (95% confidence interval [CI], 1.02–3.38). After adjusting for sex, etiology, hepatocellular carcinoma, MELDNa, ascites, encephalopathy, and hypertension, sarcopenia was associated with a 2.38× increased odds of being frail (95% CI, 1.17–4.85). After stratifying by sex and adjusting for MELDNa, sarcopenia among males was associated with a significantly increased odds of frailty (odds ratio 2.81, 95% CI, 1.19–6.67), whereas sarcopenia among females was not (odds ratio 1.38; 95% CI, 0.45–4.25). DISCUSSION: In patients with cirrhosis, sarcopenia was associated with a nearly 2-fold increased odds of being frail. Two-thirds of frail men displayed sarcopenia compared with only one-quarter of frail women. Contributors to the frail phenotype may differ by sex and support the need for sex-specific strategies to reduce frailty in this population.
Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development

Abstract Background Maternal inflammation in early pregnancy has been identified epidemiologically as a prenatal pathogenic factor for the offspring's later mental illness. Early newborn manifestations of the effects of maternal inflammation on human fetal brain development are largely unknown. Methods Maternal infection, depression, obesity, and other factors associated with inflammation were assessed at 16 weeks gestation, along with maternal C-reactive protein (CRP), cytokines, and serum choline. Cerebral inhibition was assessed by inhibitory P50 sensory gating at 1 month of age, and infant behavior was assessed by maternal ratings at 3 months of age. Results Maternal CRP diminished the development of cerebral inhibition in newborn males but paradoxically increased inhibition in females. Similar sex-dependent effects were seen in mothers' assessment of their infant's self-regulatory behaviors at 3 months of age. Higher maternal choline levels partly mitigated the effect of CRP in male offspring. Conclusions The male fetal-placental unit appears to be more sensitive to maternal inflammation than females. Effects are particularly marked on cerebral inhibition. Deficits in cerebral inhibition 1 month after birth, similar to those observed in several mental illnesses, including schizophrenia, indicate fetal developmental pathways that may lead to later mental illness. Deficits in early infant behavior follow. Early intervention before birth, including prenatal vitamins, folate, and choline supplements, may help prevent fetal development of pathophysiological deficits that can have life-long consequences for mental health.
Metabolite Profiling of Ortho-, Meta- and Para-Fluorofentanyl by Hepatocytes and High-Resolution Mass Spectrometry

Abstract New psychoactive substances are emerging on the illegal drug market. Synthetic opioids including fentanyl analogues are of special concern due to their high potency. This indicates the possibility of low drug concentrations in vivo and calls for sensitive analytical methods and identification of the most appropriate analytical targets. In this study the in vitro metabolism of ortho-, meta- and para-fluorofentanyl, three fluorinated derivatives of fentanyl, has been investigated using human hepatocytes and compared to the results from an authentic human urine sample. Based on knowledge on the metabolism of similar fentanyl analogues N-dealkylation and hydroxylation was hypothesized to be the most central pathways. The three fluorofentanyl isomers were incubated with pooled human hepatocytes at 1, 3 and 5 h. Liquid chromatography quadrupole time of flight mass spectrometry operating in data-dependent mode was used to analyse the hepatocyte samples, as well as the hydrolysed and non-hydrolysed authentic urine sample. Data were analysed by a targeted approach with a database of potential metabolites. The major metabolite formed in vitro was the N-dealkylation product norfluorofentanyl. In addition various hydroxylated metabolites, a N-oxide, dihydrodiol metabolites and a hydroxymethoxy metabolite were found. In total, 14 different metabolites were identified for each fluorofentanyl isomer. In the authentic urine sample, three metabolites were detected in addition to the ortho-fluorofentanyl parent compound, with hydroxymethoxy metabolite having the highest abundance followed by norfluorofentanyl and a metabolite hydroxylated on the ethylphenyl ring. This in vitro study showed that the metabolic pattern for ortho-, meta-, and para-fluorofentanyl was close to those previously reported for other fentanyl analogues. We suggest that the hydroxymethoxy metabolite and the metabolite hydroxylated on the ethylphenyl ring should be the metabolites primarily investigated in further studies to determine the most appropriate marker for intake of fluorofentanyl derivatives in urine drug screening for human subjects.
Which Patients Would Most Likely to Benefit: MIGS or MEGS, Which One Is It?

Abstract The availability of ab interno minimally invasive glaucoma surgery (MIGS) has promoted an international interest in this procedure. Our purpose is to define the role of MIGS in the constant evolving glaucoma treatment algorithm. Current MIGS approaches to lowering intraocular pressure (IOP) include increasing trabecular outflow (iStent trabecular microbypass stent, iStent inject, Hydrus Microstent, Kahook Dual Blade goniotomy, Trabectome ab interno trabeculectomy, Excimer laser trabeculotomy, and goniotomy-assisted transluminal trabeculotomy), increasing uveoscleral outflow with suprachoroidal shunts (Cypass microstent), and developing subconjunctival filtration (XEN gel stent and InnFocus microshunt). The efficacy of each depends on the achievement of desired target IOP reduction in a specific patient. The determination of whether a procedure is either a MIGS or minimally effective glaucoma surgery (MEGS) procedure is based on their efficacy and complications. Aqueous humor angiography suggests that success of trabecular bypass MIGS may not be patient-dependent only, but it may be affected by the location and flow of aqueous through collector channels. The future use of aqueous angiography may permit customized treatment of trabecular meshwork dependent MIGS procedures.
IMPACf OF FARMER'S STATUS ON MILK PRODUCfION-IN TRIBAL AREA OF KINWAT TAHSIL (MARATHWADA REGION)

Total ten villages were identified and from each village 20 farmers were considered for study. As regards to milk production, it was observed that the age and education of dairy farmers found no significant relationship with milk production, whereas the size of land holding and occupation of the dairy farmers had positive and significant relation with milk production. The matured farmers (46 to 55 years) are having more inclination towards dairy farming than young and older farmer.
Sensitive and Selective Measurement of Serotonin In Vivo Using Fast Cyclic Square-Wave Voltammetry.

Although N-shaped fast scan cyclic voltammetry (N-FSCV) is well-established as an electroanalytical method to measure extracellular serotonin concentrations in vivo it is in need of improvement in both sensitivity and selectivity. Based on our previous studies using fast cyclic square-wave voltammetry (FCSWV) for in vivo dopamine measurements, we have modified this technique to optimize the detection of serotonin in vivo. A series of large amplitude square-shaped potentials was superimposed onto an N-shaped waveform to provide cycling through multiple redox reactions within the N-shaped waveform to increase sensitivity and selectivity to serotonin when combined with a two dimensional voltammogram. N-shaped fast cyclic square-wave voltammetry (N-FCSWV) showed significantly higher sensitivity to serotonin compared to conventional N-FSCV. In addition, N-FCSWV showed better performance than conventional N-shaped FSCV in differentiating serotonin from its major interferents, dopamine and 5-hydroxyindoleascetic acid (5-HIAA). It was also confirmed that the large amplitude of the square waveform did not influence local neuronal activity, and it could monitor electrical stimulation evoked phasic release of serotonin in the rat substantia nigra pars reticulata (SNr) before and after systemic injection of escitalopram (ESCIT, 10 mg/kg i.p.), a serotonin selective reuptake inhibitor.
Genetic merit for fertility alters the bovine uterine luminal fluid proteome†

Abstract Over the last decades, fertility of dairy cows has declined due to selection strategies focusing on milk yield. To study the effect of genetic merit for fertility on the proteome of the bovine uterine luminal fluid, Holstein heifers with low- and two groups of heifers with high-fertility index (high-fertility Holstein and Montbéliarde) were investigated. To focus on the maternal effect, heifers from all groups were synchronized and received on Day 7 high-quality embryos. Uterine luminal fluid from Day 19 pregnant heifers was analyzed in a holistic proteomic approach using nano-LC-MS/MS analysis combined with a label-free quantification approach. In total, 1737 proteins were identified, of which 597 differed significantly in abundance between the three groups. The vast majority of proteome differences was found comparing both high-fertility groups to the low-fertility Holstein group, showing that the genetic predisposition for fertility is prevalent regarding the uterine luminal fluid proteome. Evaluation of this dataset using bioinformatic tools revealed an assignment of higher abundant proteins in low-fertility Holstein to several metabolic processes, such as vitamin metabolic process, which comprises folate receptor alpha (FOLR1) and retinol-binding protein, indicating an involvement of disturbed metabolic processes in decreased fertility. Moreover, immune system-related proteins — lactotransferrin and chromogranin A — were enriched in low-fertility cows together with interferon tau 3 h and interferon tau-2. Our results indicate that the genetic merit for fertility leads to substantial quantitative differences at the level of proteins in uterine fluid of pregnant animals, thus altering the microenvironment for the early conceptus. Summary sentence The proteome of bovine uterine fluid, which is crucial for conceptus development prior to implantation, is significantly altered by the genetic merit for fertility.
Serum hepatic biochemistry and electrophoretic protein profile of healthy and Ehrlich tumor-bearing mice treated with extracts of Agaricus blazei Murill

Biocompostos de Agaricus blazei Murril representam imunomoduladores naturais promissores para uso no tratamento de neoplasias. Objetivou-se avaliar o perfil bioquimico hepatico serico camundongos saudaveis ou portadores do tumor de Ehrlich tratados com diferentes extratos de A. blazei. Em pH acido ou neutro e sob temperatura de extracao de 60 oC em banho-maria ou 37 oC em banho ultrassonico foram obtidos extratos totais, de sobrenadante e de polissacarideos de A. blazei. Apos administracao oral dos tratamentos para camundongos por 21 dias foram realizadas coletas de sangue e determinadas as atividades de aspartato aminotransferase (AST), alanina aminotransferase (ALT), creatina quinase (CK) e as concentracoes de ureia, proteina total, albumina, globulinas e fracoes alfa, beta e gama-globulina. A presenca do tumor de Ehrlich foi responsavel por aumento significativo nas atividades sericas de AST e CK e das concentracoes de globulinas totais e da fracao gama-globulina, alem de reducao dos niveis de albumina e das alfa2-globulinas. Os extratos de polissacarideos de A. blazei reduziram as atividades sericas de AST e ALT, provavelmente devido a um efeito hepatoprotetor. Alem disto, extratos de polissacarideos e sobrenadante inibiram o aumento das gama-globulinas induzido pelo tumor. Assim, as fracoes de polissacarideos e sobrenadante do extrato de A. blazei apresentam bom potencial para uso complementar ao tratamento antineoplasico.
When Has a Knee or Hip Replacement Failed? A Patient Perspective

Objective. To define the patient perspective of what constitutes a failure of total joint replacement (TJR) in a qualitative study. Methods. We used the nominal group technique (NGT) with participants who had undergone elective total hip replacements (THR) and/or total knee replacements (TKR) to answer the question, “When would you consider a knee or hip replacement to be a failure? ” Results. We performed 8 nominal groups with 42 participants, all of whom had undergone THR and/or TKR between 2016 and 2018. Of these, 48% were male, 17% were Black, 79% had college education or above, and 76% had had osteoarthritis as the underlying diagnosis. The nominated responses/themes that were ranked the highest by the participants were as follows: (1) refractory index joint pain (80 votes); (2) occurrence of postoperative adverse events (54 votes); (3) unable to resume normal activities or go back to work (38 votes); (4) little or no improvement in quality of life (35 votes); (5) early revision surgery (35 votes); (6) death (7 votes); and (7) other, including nurse or physician negligence (2 votes) and expectation-outcome mismatch (1 vote). Conclusion. Lack of relief of pain or restoration of function or quality of life, or the occurrence of surgical complications after TJR were defined as TJR failure by participants. Functional TJR failure seems as important or more important than surgical failure. This patient perspective emphasizing pain, function, satisfaction, adverse events, and revision as critical domain components of TJR failure independently validated their inclusion in the TJR core domain set for clinical trials in people undergoing knee or hip TJR.
Swept-Tone Stimulus-Frequency Otoacoustic Emissions in Human Newborns

Several types of otoacoustic emissions have been characterized in newborns to study the maturational status of the cochlea at birth and to develop effective tests of hearing. The stimulus-frequency otoacoustic emission (SFOAE), a reflection-type emission elicited with a single low-level pure tone, is the least studied of these emissions and has not been comprehensively characterized in human newborns. The SFOAE has been linked to cochlear tuning and is sensitive to disruptions in cochlear gain (i.e., hearing loss) in adult subjects. In this study, we characterize SFOAEs evoked with rapidly sweeping tones in human neonates and consider the implications of our findings for human cochlear maturation. SFOAEs were measured in 29 term newborns within 72 hr of birth using swept tones presented at 2 oct/s across a four-octave frequency range (0.5–8 kHz); 20 normal-hearing young adults served as a control group. The prevalence of SFOAEs in newborns was as high as 90% (depending on how response “presence” was defined). Evidence of probe-tip leakage and abnormal ear-canal energy reflectance was observed in those ears with absent or unmeasurable SFOAEs. Results in the group of newborns with present stimulus-frequency emissions indicate that neonatal swept-tone SFOAEs are adult-like in morphology but have slightly higher amplitude compared with adults and longer SFOAE group delays. The origin of these nonadult-like features is probably mixed, including contributions from both conductive (ear canal and middle ear) and cochlear immaturities.