Miracle-dz/UniFAR-FTUs huggingface dataset:
European Conference on Information Systems ( ECIS ) 5-15-2012 ENHANCED BI SYSTEMS WITH ON-DEMAND DATA BASED ON SEMANTIC-ENABLED ENTERPRISE SOA

Since the 1990s, companies have been investing into IT infrastructure initiatives such as Enterprise Resource Planning (ERP) systems, Supply Chain Management (SCM) systems, and Customer Relationship Management (CRM) systems in order to increase efficiency, effectiveness, and internal process integration, among other goals. The current value of Business Intelligence (BI) for companies could be summarized by two main achievements: improvement of management of processes and improvement of operational processes. This paper will identify current requirements of BI and present a linkage to service-oriented architectures including added-values. Semantic-enabled Enterprise Service-Oriented Architecture (SESOA) is an enterprise solution that links businesses to external systems based on Web Services and SOA concept. It represents a lightweight web application that annotates Web Services that are coming from different service providers with semantics so that the indexing and discovery of these services can be more comprehensive. BI applications can be considered as service consumers in SESOA and can discover, select and invoke the services supplied by the external systems (service providers). In this way, SESOA forms the bridge between SOA and BI concepts to deliver in real time the “on-demand” data as services and this opens the BI market to include SMEs as main resources of these services.
Early Diagnostics on Team Communication: Experience-Based Forecasts on Student Software Projects

Effective team communication is a prerequisite for software quality and project success. It implies correctly elicited customer requirements, conduction of occurring change requests and to adhere releases. Team communication is a complex construct that consists of numerous characteristics, individual styles, influencing factors and dynamic intensities during a project. These elements are complicated to be measured or scheduled, especially in newly formed teams. According to software developers with few experiences in teams, it would be highly desirable to recognize dysfunctional or underestimated communication behaviors already in early project phases. Otherwise, negative affects may cause delay of releases or even endanger software quality. We introduce an approach on the feasibility of forecasting team's communication behavior in student software projects. We build a very first forecasting model that involves software engineering and industrial psychological terms to extract multi week communication forecasts with accurate results. The model consists of a k-nearest neighbor machine learning algorithm and is trained and evaluated with 34 student software projects from a previously taken field study. This study is an encouraging first step towards forecasting team communication to reveal potential miscommunications during a project. It is our aim to give young software developing teams an experience-based assistance about their information flow and enable adjustment for dysfunctional communication, to avoid fire fighting situation or even risks of alternating software qualities.
Three-beam spectral-domain optical coherence tomography for retinal imaging

Abstract. A three-beam spectral domain optical coherence tomography system (OCT) whose center wavelength is 840 nm was developed. The three beams focus on fundus 3.1 mm apart from each other and are detected by a single line sensor. The distance between the beams is fixed and the beams scan a total area of 10×10 mm2 while keeping this separation during three-dimensional (3-D) measurement. The line rate of the sensor is 70 kHz, therefore the total speed is equivalent to 210k A-scans per second in this system. A 1000(x)×500(z)×250(y) voxel volumetric 3D OCT data set can be acquired within 2 s. Images of a model eye, a healthy human eye and a diseased eye taken by this system are shown and evaluated. The image quality of one B-Scan is as good as an image from a single-beam OCT. Adjustment among the beams is solved by additional signal processing using a model eye. A multi-beam OCT has the potential not only for high speed imaging but also functional imaging although problems such as compensation among the beams and motion artifacts must be solved.
Light spanners for Snowflake Metrics

A classic result in the study of spanners is the existence of light low-stretch spanners for Euclidean spaces. These spanners have arbitrary low stretch, and weight only a constant factor greater than that of the minimum spanning tree of the points (with dependence on the stretch and Euclidean dimension). A central open problem in this field asks whether other spaces admit low weight spanners as well -- for example metric space with low intrinsic dimension -- yet only a handful of results of this type are known. In this paper, we consider snowflake metric spaces of low intrinsic dimension. The α-snowflake of a metric (X, δ) is the metric (X, δα), for 0 < α < 1. By utilizing an approach completely different than those used for Euclidean spaces, we demonstrate that snowflake metrics admit light spanners. Further, we show that the spanner is of diameter O(log n), a result not possible for Euclidean spaces. As an immediate corollary to our spanner, we obtain dramatic improvements in algorithms for the traveling salesman problem in this setting, achieving a polynomial-time approximation scheme with near-linear runtime. Along the way, we also show that all ℓp spaces admit light spanners, a result of interest in its own right.
HOXA9 regulates miR-155 in hematopoietic cells

HOXA9-mediated up-regulation of miR-155 was noted during an array-based analysis of microRNA expression in Hoxa9−/−bone marrow (BM) cells. HOXA9 induction of miR-155 was confirmed in these samples, as well as in wild-type versus Hoxa9-deficient marrow, using northern analysis and qRT–PCR. Infection of wild-type BM with HOXA9 expressing or GFP+ control virus further confirmed HOXA9-mediated regulation of miR-155. miR-155 expression paralleled Hoxa9 mRNA expression in fractionated BM progenitors, being highest in the stem cell enriched pools. HOXA9 capacity to induce myeloid colony formation was blunted in miR-155-deficient BM cells, indicating that miR-155 is a downstream mediator of HOXA9 function in blood cells. Pu.1, an important regulator of myelopoiesis, was identified as a putative down stream target for miR-155. Although miR-155 was shown to down-regulate the Pu.1 protein, HOXA9 did not appear to modulate Pu.1 expression in murine BM cells.
Ion Beam Synthesis of Carbon Assisted Nanosystems in Silicon Based Substrates

The systematic study of the formation of β-SiC formed by low energy carbon ion (C-)implantation into Si followed by high temperature annealing is presented. The research is performed to explore the optimal annealing conditions. The formation of crystalline β-SiC is clearly observed in the sample annealed at 1100 °C for a period of 1 hr. Quantitative analysis is performed in the formation of β-SiC by the process of implantation of different carbon ion fluences of 1×1017, 2×1017, 5×1017, and 8×1017 atoms /cm2 at an ion energy of 65 keV into Si. It is observed that the average size of β-SiC crystals decreased and the amount of β-SiC crystals increased with the increase in the implanted fluences when the samples were annealed at 1100°C for 1 hr. However, it is observed that the amount of β-SiC linearly increased with the implanted fluences up to 5×1017 atoms /cm2. Above this fluence the amount of β-SiC appears to saturate. The stability of graphitic C-C bonds at 1100°C limits the growth of SiC precipitates in the sample implanted at a fluence of 8×1017 atoms /cm2 which results in the saturation behavior of SiC formation in the present study. Secondly, the carbon cluster formation process in silica and the characterization of formed clusters is presented. Silicon dioxide layers ~500 nm thick are thermally grown on a Si (100) wafer. The SiO2 layers are then implanted with 70 keV carbon ions at a fluence of 5×1017 atoms/cm2. The implanted samples are annealed 1100 °C for different time periods of 10 min., 30 min., 60 min., 90 min., and 120 min., in the mixture of argon and hydrogen gas (96 % Ar + 4% hydrogen). Photoluminescence spectroscopy reveals UV to visible emission from the samples. A detail mechanism of the photoluminescence and its possible origin is discussed by correlating the structural and optical properties of the samples. Raman spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, spectroscopy, photoluminescence spectroscopy, and transmission electron microscopy are used to characterize the samples.
KOMODO: a web tool for detecting and visualizing biased distribution of groups of homologous genes in monophyletic taxa

The enrichment analysis is a standard procedure to interpret ‘omics’ experiments that generate large gene lists as outputs, such as transcriptomics and protemics. However, despite the huge success of enrichment analysis in these classes of experiments, there is a surprising lack of application of this methodology to survey other categories of large-scale biological data available. Here, we report Kegg Orthology enrichMent-Online DetectiOn (KOMODO), a web tool to systematically investigate groups of monophyletic genomes in order to detect significantly enriched groups of homologous genes in one taxon when compared with another. The results are displayed in their proper biochemical roles in a visual, explorative way, allowing users to easily formulate and investigate biological hypotheses regarding the taxonomical distribution of genomic elements. We validated KOMODO by analyzing portions of central carbon metabolism in two taxa extensively studied regarding their carbon metabolism profile (Enterobacteriaceae family and Lactobacillales order). Most enzymatic activities significantly biased were related to known key metabolic traits in these taxa, such as the distinct fates of pyruvate (the known tendency of lactate production in Lactobacillales and its complete oxidation in Enterobacteriaceae), demonstrating that KOMODO could detect biologically meaningful differences in the frequencies of shared genomic elements among taxa. KOMODO is freely available at http://komodotool.org.
A deployable framework for mobile telemedicine applications.

In recent years, the shortage of medical specialists and access to medical information has necessitated a growing interest for cost effective and efficient telemedicine tools for healthcare delivery. Mobile telemedicine applications are aimed at meeting the mobility requirements of patients and doctors by integrating wireless communications for different health care services and education.Although, telemedicine holds great promises in enhancing health care delivery in rural area and developing countries, only a few applications exist because of poor frameworks for their deployments. This paper, aims at providing a deployable framework for Mobile Telemedicine Applications for Tropical Diseases (MTATD). MTATD presented here, provides access to a telemedicine unit via hand held devices over a PSTN/GSM and the Internet for a collaborative health care delivery and education between patients and care providers.
Effects of Image Characteristics on Performance of Tumor Delineation Methods: A Test–Retest Assessment

PET can be used to monitor response during chemotherapy and assess biologic target volumes for radiotherapy. Previous simulation studies have shown that the performance of various automatic or semiautomatic tumor delineation methods depends on image characteristics. The purpose of this study was to assess test–retest variability of tumor delineation methods, with emphasis on the effects of several image characteristics (e.g., resolution and contrast). Methods: Baseline test–retest data from 19 non–small cell lung cancer patients were obtained using 18F-FDG (n = 10) and 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) (n = 9). Images were reconstructed with varying spatial resolution and contrast. Six different types of tumor delineation methods, based on various thresholds or on a gradient, were applied to all datasets. Test–retest variability of metabolic volume and standardized uptake value (SUV) was determined. Results: For both tracers, size of metabolic volume and test–retest variability of both metabolic volume and SUV were affected by the image characteristics and tumor delineation method used. The median volume test–retest variability ranged from 8.3% to 23% and from 7.4% to 29% for 18F-FDG and 18F-FLT, respectively. For all image characteristics studied, larger differences (≤10-fold higher) were seen in test–retest variability of metabolic volume than in SUV. Conclusion: Test–retest variability of both metabolic volume and SUV varied with tumor delineation method, radiotracer, and image characteristics. The results indicate that a careful optimization of imaging and delineation method parameters is needed when metabolic volume is used, for example, as a response assessment parameter.
Space-time block codes from nonassociative division algebras

Associative division algebras are a rich source of fully diverse space-time block codes (STBCs). In this paper the systematic construction of fully diverse STBCs from nonassociative algebras is discussed. As examples, families of fully diverse $2\times 2$, $2\times 4$ multiblock and $4\times 4$ STBCs are designed, employing nonassociative quaternion division algebras.
Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis

Changes of bone turnover with aging are responsible for bone loss and play a major role in osteoporosis. Although an increase of bone turnover has been documented at the time of menopause, the subsequent abnormalities of bone resorption and formation and their potential role in determining bone mass in the elderly have not been investigated. To address this issue, we have measured a battery of new sensitive and specific markers of bone turnover in a population‐based study of 653 healthy women analyzed cross‐sectionally, including 432 women postmenopausal from 1 to 40 years, and the data were correlated with bone mineral density (BMD) measured by dual‐energy X‐ray absorptiometry (DXA) at different skeletal sites. Bone formation was assessed by serum osteocalcin (OC), serum bone‐specific alkaline phosphatase (B‐ALP), serum C‐propeptide of type I collagen (PICP), and bone resorption by the urinary excretion of two pyridinoline cross‐linked peptides (NTX and CTX). Bone turnover increased in perimenopausal women with both irregular menses and elevated serum follicle stimulating hormone (FSH). Menopause induced a 37–52% and 79–97% increase in the bone formation and bone resorption marker levels, respectively (p < 0.0001 except for PICP). In postmenopausal women, bone formation markers did not decrease with age. When resorption markers were corrected by whole body bone mineral content (BMC), the fraction of bone resorbed per day was not correlated with age in postmenopausal women and remained elevated for up to 40 years after menopause. In premenopausal women, the bone turnover rate accounted for only 0–10% of the variation in whole body BMC, total hip, distal radius, and lumbar spine BMD. With increasing time after menopause, the importance of the bone turnover rate as a determinant of bone mass increased at all sites and accounted for up to 52% of the BMD variance in elderly women. Thus, in women 20 years or more postmenopause, bone turnover was higher in those in the lowest quartile than in those in the highest quartile of BMD. In elderly women, 20 years since menopause and over, but not in younger ones, serum PTH was negatively correlated with serum 25‐hydroxyvitamin D (r = −0.22,p < 0.05) and explained only 5–8% of the bone turnover variance (p < 0.01‐0.001). These data indicate that the overall rates of both bone formation and bone resorption remain high in elderly women. The rate of bone turnover appears to play an increasing role as a determinant of bone mass with increasing time since menopause with a high bone turnover rate being associated with a low bone mass. Thus assessing bone marker levels may be useful in the evaluation of osteoporosis risk. In elderly women, secondary hyperparathyroidism caused in part by reduced serum 25‐hydroxyvitamin D appears to be a marginal determinant of an increased bone turnover rate.
Information Slices: Visualising and Exploring Large Hierarchies using Cascading, Semi-Circular Discs

This paper presents work in progress on a new technique for visu- alising and manipulating large hierarchies. The information slices approach compactly visualises hierarchical structures using a series of semi-circular discs. The technique is described in the context of our early experience with a prototype file system visualiser based on information slices. Over the last few years, the emerging field of information visuali- sation has resulted in a numerous techniques for helping visualise and make sense of large information spaces (10). Among these are several techniques for visualising and interacting with large hierar- chies which go beyond the traditional approach taken in 2d scrolling browsers such as the Windows Explorer. Treemaps (6, 9) are space-filling visualisations of hierarchies based on successive horizontal and vertical subdivision of screen rectangles. The area of each rectangle is proportional to some at- tribute of the underlying hierarchy such as the (total) size of each subtree. Xdu (4) is a utility for the X window system which displays a graphical disk usage for Unix file systems. Rectangles are stacked from left to right as the directory tree is descended. The current di- rectory is represented by the leftmost rectangle, which is the entire height of the window. Subdirectories are represented by neighbour- ing rectangles in the next column, whose height are proportional to the size of each subdirectory. The hyperbolic browser (7) uses a focus and context technique based on hyperbolic geometry. A hierarchy is laid out uniformly on the hyperbolic plane and then mapped to the unit disc for display on screen. Nodes in the centre of the disc are largest and nodes are assigned progressively less space towards the perimeter of the disc. Cheops (3) is based on multiple re-use of overlaid triangles in the display. Working top-down, the selection of a node (triangle) at a particular level designates that node's children are to be represented
Estimating unknown object dynamics in human-robot manipulation tasks

Knowing accurately the dynamic parameters of a manipulated object is required for common coordination strategies in physical human-robot interaction. Bias in object dynamics results in inaccurately calculated robot wrenches, which may disturb the human during interaction and bias the recognition of the human motion intention. This paper presents an identification strategy of object dynamics for physical human-robot interaction, which allows the tracking of desired human motion and inducing the motions necessary for parameter identification. The estimation of object dynamics is performed online and the estimator minimizes the least square error between the measured and estimated wrenches acting on the object. Identification-relevant motions are derived by analyzing the persistence of excitation condition, necessary for estimation convergence. Such motions are projected in the null space of the partial grasp matrix, relating the human and the robot redundant motion directions, to avoid disturbance of the human desired motion. The approach is evaluated in a physical human-robot object manipulation scenario.
An Improved Graph Model for Chinese Spell Checking

In this paper, we propose an improved graph model for Chinese spell checking. The model is based on a graph model for generic errors and two independentlytrained models for specific errors. First, a graph model represents a Chinese sentence and a modified single source shortest path algorithm is performed on the graph to detect and correct generic spelling errors. Then, we utilize conditional
Humoral immunocompetence in relation to condition, size, asymmetry and MHC class II variation in great snipe (Gallinago media) males

At the centre of the vertebrate immune system is a group of proteins called MHC (major histocompatibility complex) molecules. These function in self – non self recognition and activation of the immune defence against intruding parasites and pathogens. In this thesis I have investigated individual variation in MHC class II genes and antibody producing ability in relation to ecology and behaviour in the great snipe (Gallinago media), a lekking bird, breeding in northern Europe. There was much variation in the MHC genes of the great snipe and the sequence data show that balancing selection has been acting on these genes. I found genetic differentiation in the MHC between two separate geographic regions of the great snipe distribution. Furthermore, this structure was more pronounced than that previously found in neutral genetic markers, suggesting that different selection pressures (possibly resulting from variation in parasitic fauna) are acting in these different regions. The birds produced specific antibodies following injection with two novel antigens. Males that were chosen as mates, had higher antibody titers than their neighbouring males, suggesting that this ability may be important in female mate choice. Such choice could give the offspring an enhanced immune system or could favour females directly by avoidance of sexually transmitted diseases. Females choosing to mate with a male having a different set of MHC genes than their own could give the offspring immune system the ability to react to a wide range of parasites. No such mate choice could, however, be found in the great snipe. Instead, females preferred males with certain MHC alleles, irrespective of their own MHC type. If those alleles confer resistance to parasites currently prevailing in the population, such resistance would be inherited by the offspring, thereby enhancing their fitness.
CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery.

AIM We previously showed that cellular repressor of E1A-stimulated genes (CREG) is up-regulated during serum starvation-induced vascular smooth muscle cell (SMC) differentiation. The aim of this study was to determine the role of CREG in maintaining the quiescent, differentiated phenotype of SMCs both in culture and in balloon-injured rat carotid artery. METHODS AND RESULTS In cultured SMCs recombinant virus-mediated CREG expression enhanced cellular differentiation, inhibited proliferation, and reduced synthesis of extracellular matrix component fibronectin. In contrast, CREG knockdown via retroviral transfer of short hairpin RNAs abrogated serum starvation-induced SMC differentiation and growth arrest. Both immunostaining and Western analysis demonstrated marked down-regulation of CREG in the vascular media after balloon injury to the rat carotid artery. Retrovirus-mediated CREG transfer to the injured artery inhibited SMC dedifferentiation and proliferation, and reduced neointimal hyperplasia. CONCLUSION These results suggest that CREG participates in the maintenance of quiescent mature SMC phenotype in the arterial media by promoting SMC differentiation and growth arrest and that CREG gene transfer has therapeutic potential for vascular diseases associated with neointimal hyperplasia.