Miracle-dz/UniFAR-FTUs huggingface dataset:
Pelagic–benthic resource polymorphism in Schizopygopsis thermalis Herzenstein 1891 (Pisces, Cyprinidae) in a headwater lake in the Salween River system on the Tibetan Plateau

Abstract Resource polymorphism is a ubiquitous phenomenon in vertebrates and may represent a critical intermediate stage in speciation. Freshwater lakes in high‐altitude areas represent a natural system for understanding resource polymorphism in fishes benefiting from diverse lacustrine environments and species‐poor fish assemblages. We report resource polymorphism in a cyprinid fish, Schizopygopsis thermalis, in Lake Amdo Tsonak Co, a headwater lake in the upper Salween River system. Two discrete intraspecific morphs, planktivorous and benthivorous, were identified according to geometric morphometrics and traditional univariate linear measures. The planktivorous morph exhibits a longer head, longer upper and lower jaw, larger asymptotic standard length (L∞), lower growth rate (k), and higher growth performance index (φ) than the benthivorous morph. With respect to descriptive traits, the planktivorous morph possesses a large, terminal mouth and obvious mucus pores on the cheek and chin, while the benthivorous morph is characterized by a more inferior mouth with a sharpen horny edge on the lower jaw and unconspicuous mucus pores. The discrete pelagic–benthic resources and low interspecific competition in the lake system might drive the initial differentiation of the two morphs, and partial spatial reproductive isolation in breeding further maintains and reinforces the differences between them.
Insect oviposition preference between Epichloë‐symbiotic and Epichloë‐free grasses does not necessarily reflect larval performance

Abstract Variation in plant communities is likely to modulate the feeding and oviposition behavior of herbivorous insects, and plant‐associated microbes are largely ignored in this context. Here, we take into account that insects feeding on grasses commonly encounter systemic and vertically transmitted (via seeds) fungal Epichloë endophytes, which are regarded as defensive grass mutualists. Defensive mutualism is primarily attributable to alkaloids of fungal origin. To study the effects of Epichloë on insect behavior and performance, we selected wild tall fescue (Festuca arundinacea) and red fescue (Festuca rubra) as grass–endophyte models. The plants used either harbored the systemic endophyte (E+) or were endophyte‐free (E−). As a model herbivore, we selected the Coenonympha hero butterfly feeding on grasses as larvae. We examined both oviposition and feeding preferences of the herbivore as well as larval performance in relation to the presence of Epichloë endophytes in the plants. Our findings did not clearly support the female's oviposition preference to reflect the performance of her offspring. First, the preference responses depended greatly on the grass–endophyte symbiotum. In F. arundinacea, C. hero females preferred E+ individuals in oviposition‐choice tests, whereas in F. rubra, the endophytes may decrease exploitation, as both C. hero adults and larvae preferred E− grasses. Second, the endophytes had no effect on larval performance. Overall, F. arundinacea was an inferior host for C. hero larvae. However, the attraction of C. hero females to E+ may not be maladaptive if these plants constitute a favorable oviposition substrate for reasons other than the plants' nutritional quality. For example, rougher surface of E+ plant may physically facilitate the attachment of eggs, or the plants offer greater protection from natural enemies. Our results highlight the importance of considering the preference of herbivorous insects in studies involving the endophyte‐symbiotic grasses as host plants.
Experimental assessment of biotic and abiotic filters driving community composition

Abstract Species occurrence in a site can be limited by both the abiotic environment and biotic interactions. These two factors operate in concert, but their relative importance is often unclear. By experimentally introducing seeds or plants into competition‐free gaps or into the intact vegetation, we can disentangle the biotic and abiotic effects on plant establishment. We established a seed‐sowing/transplant experiment in three different meadows. Species were introduced, as seeds and pregrown transplants, into competition‐free gaps and the intact vegetation. They included 12 resident plants from the locality and 18 species typical for different habitats. Last two years, gaps were overgrown with vegetation from surrounding plants and we observed the competitive exclusion of our focal plants. We compared plant survival with the expected occurrence in target locality (Beals index). Many of the species with habitat preferences different from our localities were able to successfully establish from seeds and grow in the focal habitat if competition was removed. They included species typical for much drier conditions. These species were thus not limited by the abiotic conditions, but by competition. Pregrown transplants were less sensitive to competition, when compared to seedlings germinated from seeds. Beals index significantly predicted both species success in gaps and the ability to withstand competition. Survival in a community is dependent on the adaptation to both the abiotic environment and biotic interactions. Statistically significant correlation coefficients of the ratio of seedling survival in vegetation and gaps with Beals index suggest the importance of biotic interactions as a determinant of plant community composition. To disentangle the importance of abiotic and biotic effect on plant establishment, it is important to distinguish between species pool as a set of species typically found in given community type (determined by Beals index) and a set of species for which the abiotic conditions are suitable.
Feeling Asian Together: Coping With #COVIDRacism on Subtle Asian Traits

Since the onset of COVID-19, incidents of racism and xenophobia have been occurring globally, especially toward people of East Asian appearance and descent. In response, this article investigates how an online Asian community has utilized social media to engage in cathartic expressions, mutual care, and discursive activism amid the rise of anti-Asian racism and xenophobia during COVID-19. Specifically, we focus on the 1.7-million-strong Facebook group “Subtle Asian Traits” (SAT). Throughout the COVID-19 pandemic, the 1,200 new posts it publishes daily have swiftly pivoted to the everyday lived experiences of (diaspora) East Asians around the world. In this article, we reflect on our experiences as East Asian diaspora members on SAT and share our observations of meaning-making, identity-making, and community-making as East Asians collectively coping with COVID-19 aggression between January and May 2020.
The Clinical and Pathological Features of Colorectal Cancer in Tabuk Region, Saudi Arabia: Trends in the Young and Elderly Patients

Background: Colorectal cancer (CRC) is common in the Kingdom of Saudi Arabia (KSA) and worldwide. Tabuk region, in the Northwest part of Saudi Arabia, is one of the regions with the highest incidence of the disease in the Kingdom. Objective: This study aims to compare the clinicopathological features of CRC between the young and elderly patients in Tabuk region. Methods: This is a retrospective, hospital-based, descriptive study conducted at the three main referral hospitals in Tabuk region over 5-year period between 2010 and 2014. All patients diagnosed with CRC proved with histopathology were retrieved and categorized into two groups; group one (less than 40 years of age) and group two (equal to or older than 40 years of age). The clinical and pathological features of the disease were compared between the two groups. Results: The study involved 72 patients 94.4% of whom were Saudi and 5.6% were from the South East population. Group one comprised 10 patients (13.9%) while group two were 62 (86.1%). The male to female ratio was 1.5 for group one and 1.7 for group two. Adenocarcinoma was the predominant histological type in both groups (98.6%). Lefts-sided tumours were more common in both groups (74.2 and 70%) however; a greater proportion of the patients in group 1 had more right-sided tumours (30%) than their elderly counterparts (25.8%). Advanced tumour presentation (Duke`s C+D) was more common in group 1 (90%) than in group 2 (83.8%). However, differences between the two groups was not statistically significant. Conclusion: CRC is less common among the young population in Tabuk region than other parts of Saudi Arabia and some regional countries. Demographic and genetic studies are advocated in the area to provide further explanation of these results.
Implications of acute temperature and salinity tolerance thresholds for the persistence of intertidal invertebrate populations experiencing climate change

Abstract To predict whether populations of marine animals will persist in the face of changing climate conditions, it is informative to understand how past climate conditions have shaped present‐day tolerance thresholds. We examined 4 species of intertidal invertebrates (Nucella lamellosa, Littorina scutulata, Littorina sitkana, and Balanus glandula) inhabiting the coasts of Vancouver Island, Canada, where the east coast experiences historically warmer sea surface temperature (SST), warmer low tide (i.e., emersion) rock surface temperature (RST), and lower sea surface salinity (SSS) than the west coast. To determine if east coast populations have higher tolerance thresholds to acute stress than west coast populations, animals from 3 sites per coast were exposed to stressful temperatures and salinities in common garden experiments. Emersion temperature tolerance differed between populations only in N. lamellosa and B. glandula, tolerance thresholds being 1.4–1.5°C higher on the east coast. Water temperature tolerance differed between populations only in B. glandula and L. scutulata but was highest on the west coast. No differences in salinity tolerance were observed within any species. Thus, there is limited evidence of divergence among east and west coast populations in tolerance of acute stress despite the substantial historical differences in extreme temperature and salinity conditions between coasts. However, based on present‐day summertime SST and RST and known rates of change in these parameters, we predict present‐day tolerance thresholds would be sufficient to allow adults of these populations to tolerate extreme temperatures predicted for the next several hundred years, and that even a slow rate of change in acute tolerance thresholds might suffice to keep up with future temperature extremes.
Topical Lidocaine 2% Gel for Analgesia and Patient Comfort during Interscalene Brachial Plexus and Axillary Blocks: A Noninferiority Randomized Trial

Aim: Skin infiltration with local anesthetic is commonly used to decrease patient discomfort during the administration of peripheral nerve blocks. Topically applied local anesthetic gel could provide analgesia while eliminating the need for additional injections of local anesthetics prior to placing the blocks. The primary objective of this study was a noninferiority comparison of the analgesia achieved for needle insertion and injection pain by applying a topical local anesthetic gel or by infiltrating a local anesthetic to the area for placement of an interscalene or axillary brachial plexus block. Methods: Thirty subjects undergoing surgery of the upper limb were randomized into three treatment groups. Group 1 received 10 g (10 mL) topical lidocaine 2% gel applied to the skin surface over the brachial plexus, Group 2 received a skin infiltration in the same area with 3 cc lidocaine 2%, and Group 3 received aqueous non-medicated ultrasound gel applied over the interscalene space. These treatments were applied 5 min prior to placement of the nerve block. Primary outcome variables were Visual Analogue Scale (VAS) pain scores during needle insertion and injection. Fearfulness of the nerve block was by verbal report on a 5-point Likert scale. Results: Topical lidocaine 2% gel was found to be noninferior to lidocaine infiltration in improving pain during needle insertion and injection of the interscalene and axillary brachial plexus blocks. Conclusion: Analgesia conferred by application of lidocaine gel is noninferior to that of infiltration with lidocaine 2% for pain during needle insertion and injection of the interscalene and axillary brachial plexus blocks. ISSN 2639-846X Research Article Citation: Bouts Cédric, Van Boxstael Sam, Vandepitte Catherine, et al. Topical Lidocaine 2% Gel for Analgesia and Patient Comfort during Interscalene Brachial Plexus and Axillary Blocks: A Noninferiority Randomized Controlled Trial. Anesth Pain Res. 2018; 2(2): 1-5.
Recombinase‐mediated integration of a multigene cassette in rice leads to stable expression and inheritance of the stacked locus

Efficient methods for multigene transformation are important for developing novel crop varieties. Methods based on random integrations of multiple genes have been successfully used for metabolic engineering in plants. However, efficiency of co-integration and co-expression of the genes could present a bottleneck. Recombinase-mediated integration into the engineered target sites is arguably a more efficient method of targeted integration that leads to the generation of stable transgenic lines at a high rate. This method has the potential to streamline multigene transformation for metabolic engineering and trait stacking in plants. Therefore, empirical testing of transgene(s) stability from the multigene site-specific integration locus is needed. Here, the recombinase technology based on Cre-lox recombination was evaluated for developing multigenic lines harboring constitutively-expressed and inducible genes. Targeted integration of a 5 genes cassette in the rice genome generated a precise full-length integration of the cassette at a high rate, and the resulting multigenic lines expressed each gene reliably as defined by their promoter activity. The stable constitutive or inducible expression was faithfully transmitted to the progeny, indicating inheritance-stability of the multigene locus. Co-localization of two distinctly inducible genes by heat or cold with the strongly constitutive genes did not appear to interfere with each other’s expression pattern. In summary, high rate of co-integration and co-expression of the multigene cassette installed by the recombinase technology in rice shows that this approach is appropriate for multigene transformation and introduction of co-segregating traits. Significance Statement Recombinase-mediated site-specific integration approach was found to be highly efficacious in multigene transformation of rice showing proper regulation of each gene driven by constitutive or inducible promoter. This approach holds promise for streamlining gene stacking in crops and expressing complex multigenic traits.
Clinical Characteristics of Pregnant Women With Coronavirus Disease 2019 in Wuhan, China

Abstract Background Coronavirus disease 2019 (COVID-19) has become a pandemic. Despite the growing number of patients with COVID-19 infection, data on the clinical characteristics of pregnant patients are still limited. Methods We retrospectively included childbearing-age female patients with laboratory-confirmed COVID-19 at Renmin Hospital of Wuhan University from January 15 to February 23, 2020. Demographic, clinical, radiological, laboratory, and treatment data were reviewed. Clinical characteristics of pregnant and nonpregnant patients were compared. Results One hundred eleven childbearing-age women with COVID-19 were included, including 16 patients (14.4%) with severe or critical disease. Compared with nonpregnant patients (n = 80), pregnant patients (n = 31) were less likely to have dyspnea (16.1% vs 37.5%), asthenia (3.2% vs 33.8%), and ≥3 symptoms (22.6% vs 45.0%); had a significantly higher neutrophil count (5.2 vs 2.5 ×109/L) and a higher percentage of CD3+ cells (76.7% vs 73.7%) and CD8+ cells (32.3% vs 28.4%); and had a dramatically lower percentage of lymphocytes (18.2% vs 31.8%), a lower CD4+/CD8+ ratio (1.2 vs 1.4), and a lower level of IgG (9.8 vs 11.9 g/L). Of note, pregnant patients had a significantly lower percentage of severe disease (3.2% vs 18.8%) and a substantially higher level of inflammation markers including neutrophil-to-lymphocyte ratio (4.4 vs 1.9) and systematic inflammatory index (812.8 vs 354.7) than nonpregnant patients. Seventeen live births were recorded, and all of these showed negative results of postnatal COVID-19 detection together with a normal Apgar score. Conclusions Pregnant patients with COVID-19 had a lower level of severity and an enhanced inflammatory response and cell immunity when compared with nonpregnant patients.
Fish Recruitment to a Constructed Wetland

ABSTRACT A 31.6 ha isolated, constructed wetland in east central Florida was sampled for fish over a two year period using a fyke net and minnow traps. A rich and abundant fish community rapidly developed. Cumulatively, 848 fish of 14 species were collected. Variation in abundance was observed, and reflects seasonal conditions. Gambusia affinis, Fundulus chrysotus, and Lepomis gulosis were the most abundant species. This fish community was similar to natural fish communities of the region. Fish may have been introduced to the study wetland by irrigation, transport on terrestrial or volant fauna, or a combination of the two modes.
Hydrodynamics of a twisting slender swimmer

Sea snakes propel themselves by lateral deformation waves moving backwards along their bodies faster than they swim. In contrast to typical anguilliform swimmers, however, their swimming is characterized by exaggerated torsional waves that lead the lateral ones. The effect of torsional waves on hydrodynamic forces generated by an anguilliform swimmer is the subject matter of this study. The forces, and the power needed to sustain them, are found analytically using the framework of the slender (elongated) body theory. It is shown that combinations of torsional waves and angle of attack can generate both thrust and lift, whereas combinations of torsional and lateral waves can generate lift of the same magnitude as thrust. Generation of lift comes at a price of increasing tail amplitude, but otherwise carries practically no energetic penalty.
LUMBAR SPINAL STENOSIS: EVALUATION OF PAIN AND LIFE QUALITY AFTER SURGICAL TREATMENT

ABSTRACT Objective: The objective of this study was to present an analysis of progression of the quality of life and pain in patients undergoing surgical treatment of LSS and the potential correlations between individual factors and the clinical outcome observed. Methods: We studied 111 patients undergoing surgical treatment of LSS from January 2009 to December 2011 using the functional capacity (ODI) and pain (VAS) questionnaires. The preoperative data were compared statistically with the results obtained during the postoperative follow-up at one month, six months, one year, and two years. Results: The population consisted of 60 men and 51 women. The mean age was 61.16 years at the time of surgery, 33.33% were 60 years or older. When the questionnaires were applied, we found improvement in the progressive disability assessment with a mean drop of 23.65 ODI points after 6 months of the surgical treatment and 27.47 at the end of one year of surgery compared to preoperative for this scale. There was a decline of 3.84 points (mean) in the VAS at first postoperative month. Conclusion: Surgical treatment of LSS presented favorable postoperative evolution in a 2-year follow-up regarding pain and quality of life through VAS and ODI. Level of Evidence IV; Case series.
Exploring the time window for causal inference and the multisensory integration of actions and their visual effects

Successful computer use requires the operator to link the movement of the cursor to that of his or her hand. Previous studies suggest that the brain establishes this perceptual link through multisensory integration, whereby the causality evidence that drives the integration is provided by the correlated hand and cursor movement trajectories. Here, we explored the temporal window during which this causality evidence is effective. We used a basic cursor-control task, in which participants performed out-and-back reaching movements with their hand on a digitizer tablet. A corresponding cursor movement could be shown on a monitor, yet slightly rotated by an angle that varied from trial to trial. Upon completion of the backward movement, participants judged the endpoint of the outward hand or cursor movement. The mutually biased judgements that typically result reflect the integration of the proprioceptive information on hand endpoint with the visual information on cursor endpoint. We here manipulated the time period during which the cursor was visible, thereby selectively providing causality evidence either before or after sensory information regarding the to-be-judged movement endpoint was available. Specifically, the cursor was visible either during the outward or backward hand movement (conditions Out and Back, respectively). Our data revealed reduced integration in the condition Back compared with the condition Out, suggesting that causality evidence available before the to-be-judged movement endpoint is more powerful than later evidence in determining how strongly the brain integrates the endpoint information. This finding further suggests that sensory integration is not delayed until a judgement is requested.
Junctional and cytoplasmic contributions in wound healing

Wound healing is characterized by the re-epitheliation of a tissue through the activation of contractile forces concentrated mainly at the wound edge. While the formation of an actin purse string has been identified as one of the main mechanisms, far less is known about the effects of the viscoelastic properties of the surrounding cells, and the different contribution of the junctional and cytoplasmic contractilities. In this paper, we simulate the wound healing process, resorting to a hybrid vertex model that includes cell boundary and cytoplasmic contractilities explicitly, together with a differentiated viscoelastic rheology based on an adaptive rest-length. From experimental measurements of the recoil and closure phases of wounds in the Drosophila wing disc epithelium, we fit tissue viscoelastic properties. We then analyse in terms of closure rate and energy requirements the contributions of junctional and cytoplasmic contractilities. Our results suggest that reduction of junctional stiffness rather than cytoplasmic stiffness has a more pronounced effect on shortening closure times, and that intercalation rate has a minor effect on the stored energy, but contributes significantly to shortening the healing duration, mostly in the later stages.