Miracle-dz/UniFAR-FTUs huggingface dataset:
Combined Immunotherapy with Chemotherapy versus Bevacizumab with Chemotherapy in First-Line Treatment of Driver-Gene-Negative Non-Squamous Non-Small Cell Lung Cancer: An Updated Systematic Review and Network Meta-Analysis

Background: A network meta-analysis was conducted to summarize randomized control trials and updated results to evaluate the efficacy and safety profiles of existing first-line therapies for advanced non-squamous non-small cell lung cancer (NSCLC) patients without known driver gene mutations. Patients and Methods: Eligible studies were identified following a systematic search of the Cochrane Library, PubMed, Embase, Web of Science, Wanfang Data, and the China Knowledge Resource Integrated Database from January 2000 to December 2021. Results: Nineteen trials involving 8176 patients with driver-gene-negative advanced non-squamous NSCLC were included. For patients with driver-gene-negative advanced NSCLC, immunotherapy + chemotherapy (IC) significantly prolonged overall survival (OS) (hazard ratio (HR), 0.80; 95% confidence intervals (CI): 0.67–0.95) and progression-free survival (PFS) (HR, 0.68; 95% CI: 0.53–0.86) compared with bevacizumab + chemotherapy (BC), with a similar objective response rate and incidence of ≥3 treatment-related adverse events (TRAEs) (risk ratios (RR), 0.98; 95% CI: 0.79–1.21/RR, 0.89; 95% CI: 0.61–1.28; respectively) compared with BC. IC yielded a superior PFS rate (HR, 1.59; 95% CI: 1.05–2.38) compared to BC in the subgroup of patients < 65 years old. Conclusions: Currently, IC is a more efficient first-line therapy for driver-gene-negative advanced non-squamous NSCLC patients, with prolonged PFS and OS, as well as a comparatively lower risk of ≥3 TRAEs compared to BC.
Emotional Intelligence of Students with Learning Disabilities and Students with Intellectual Disabilities

Many recent studies across the world present a dire lack of research on Emotional Intelligence (EI) in the field of individuals with disabilities. This study could be an academic call to conduct more research on the (EI) of students with disabilities. The purpose of the study is to examine the differences in (EI) between students with learning disabilities (LDs) and students with intellectual disabilities (IDs) in the kingdom of Saudi Arabia. One hundred students participated in the study: fifty students with learning disabilities aged six to twelve years and fifty students with intellectual disabilities aged eight to fifteen years. The Emotional Intelligence Picture Scale for Disabled Children (prepared by the researcher) was the standardized scale used to collect data. The results showed that there were differences between students with LDs and students with IDs in the total score and components of Emotional Intelligence. There is a relationship between age and Emotional Intelligence for both students with LDs and students with IDs. The study concluded that there is a need to introduce EI counseling programs to improve the components of EI. It can help students with IDs gain better control over their emotions and teach necessary skills for daily living. The study recommended that it is important to deal with EI over the lifespan of the disabled students to try to introduce counseling programs for the students who have problems in EI. It is useful for inclusion schools in the kingdom of Saudi Arabia, to implement the EI pictogram scale to identify the level of EI of students with disabilities.
A Rare Case of Eosinophilic Ileitis and the Role of Motorized Spiral Enteroscopy in Its Diagnosis

Introduction: Eosinophilic gastrointestinal disorders are rare idiopathic conditions characterized by eosinophilic infiltration of any area of the gastrointestinal tract. The clinical presentation is variable and depends on the location and depth of the eosinophilia. Peripheral eosinophilia or elevated serum IgE levels may be present and histological analysis is necessary to a definite diagnosis. Presentation: A 40-year-old male presented with generalized abdominal pain, nausea, vomiting, diarrhea and anorexia for 1 month and unintended weight loss for 2 months. He had anemia, peripheral eosinophilia, slight hypokalemia, an elevated fecal calprotectin and “a thin sheet of bilateral pleural effusion, reduced-volume ascites and parietal thickening of the entire ileum” in the thoracoabdominal CT scan. An elevated serum IgE was absent and stool for parasites or bacteria, viral serologies, mycobacteria direct exam and culture, and celiac disease screening were negative. The endoscopic exams showed no significant alterations; random ileal biopsies were collected by antegrade motorized spiral enteroscopy and revealed a very fragmented mucosa with inflammatory infiltrate with about 35 eosinophils per high-power field and an altered eosinophil distribution in the ileal wall. The patient initiated oral prednisolone for eosinophilic ileitis, with clinical, analytical, and imagiological improvement. Conclusion: Eosinophilic ileitis is a rare condition but should be considered in the differential diagnosis of unexplained gastrointestinal symptoms and ascites, particularly in the presence of peripheral eosinophilia. Motorized spiral enteroscopy can be helpful in the diagnosis, allowing the collection of biopsy specimens effectively and safely.
Numerical Investigation of the Impact of Maneuver on Store Separation Trajectories

Simulations of store separation are usually carried out for level flight. Store separation can be made safer if the flying vehicle simultaneously make s a maneuver. This effect is studied numerically in the present paper. Separation of a finned store from a generic wing-sting-pylon configuration with support of an ERU is computed with CFD directly coupled to flight mechanics . The computed trajectories and attitudes for level flight agree well with experiment. A method for numerical simulation of separation of external stores assuming quasi-steady flow conditions is presented. The relative movement between the aircraft and the store is discretized with a sequence of deformed and remeshed grids. Impact of various load factors on the store trajectories is simulated by assuming prescribed motion for the flying vehicle. Computations with load factors up to 4 are investigated. The influence on the trajectories is limited whereas the attitudes are clearly effected. The conlusion, in this specific case, is that store separation is safer during manuever due to simultaneous movement of the air vehicle away from the store and the fact that the influence on the trajectory is weak.
Late Quaternary Proboscidean Sites in Africa and Eurasia with Possible or Probable Evidence for Hominin Involvement

This paper presents a list of >100 publicly known late Quaternary proboscidean sites that have certain or possible traces of hominin utilization in Africa, Europe, and Asia, along with a sample of references, chronometric or estimated ages, and brief descriptions of the associated materials and bone modifications. Summary discussions of important sites are also presented. Lower Palaeolithic/Early Stone Age hominins created far fewer proboscidean site assemblages than hominins in later Palaeolithic phases, in spite of the time span being many times longer. Middle Palaeolithic/Middle Stone Age hominins created assemblages at eight times the earlier hominin rate. Upper Palaeolithic/Later Stone Age hominins created site assemblages at >90 times the rate of Lower Palaeolithic hominins. Palaeoloxodon spp. occur in nearly one third of the sites with an identified or probable proboscidean taxon and Mammuthus species are in nearly one half of the sites with identified or probable taxon. Other identified proboscidean genera, such as Elephas, Loxodonta, and Stegodon, occur in few sites. The sites show variability in the intensity of carcass utilization, the quantity of lithics bedded with bones, the extent of bone surface modifications, such as cut marks, the diversity of associated fauna, and mortality profiles.
Learnings from COVID-19 Forced Lockdown on Regional Air Quality and Mitigation Potential for South Asia

South Asia is a hotspot of air pollution with limited resilience and hence, understanding the mitigation potential of different sources is critically important. In this context the country lockdown initiated to combat the COVID-19 pandemic (during March and April 2020 that is the pre-monsoon season) provides an unique opportunity for studying the relative impacts of different emission sources in the region. Here, we analyze changes in levels of air quality species across the region during selected lockdown periods using satellite and in-situ datasets. This analysis compares air quality levels during the lockdown against pre-lockdown conditions as well as against regional long-term mean. Satellite derived AOD, NO2, and CO data indicates an increase of 9.5%, 2%, and 2.6%, respectively, during the 2020 lockdown period compared to pre-lockdown over the South Asia domain. However, individual country statistics, urban site data, and industrial grid analysis within the region indicate a more varied picture. Cities with high traffic loads reported a reduction of 12–39% in columnar NO2 during lockdown, in-situ PM2.5 measurements indicate a 23–56% percent reduction over the country capitals and columnar SO2 has an approximate reduction of 50% over industrial areas. In contrast, pollutant emissions from natural sources e.g., from biomass burning were observed to be adversely affecting the air quality in this period potentially masking expected lockdown related air quality improvements. This study demonstrates the need for a more nuanced and situation specific understanding of sources of air pollutants (anthropogenic and natural) and for these sources to be better understood from the local to the regional scale. Without this deeper understanding, mitigation strategies cannot be effectively targeted, wasting limited resources as well as risking unintended consequences both for the atmosphere and how mitigation action is perceived by the wider public. © The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.
Influence of Carbon and Oxygen on the Core Structure and Peierls Stress of Screw Dislocation in Molybdenum

The plasticity and hardness of metals are largely dependent on how dislocation interacts with solute atoms. Here, taking bcc molybdenum (Mo) as the example, the interaction of interstitial solutes carbon (C) and oxygen (O) with screw dislocation, and their influences on the dislocation motion, have been determined using first-principles calculations and thermodynamic models. Due to the incompact atomic structure and variation of electronic states in the dislocation core, C and O will segregate from the bulk system to the dislocation region. Notably, the presence of C/O at the dislocation induces the reconstruction of the core structure, from an easy-core to hard-core configuration. This originates from the fact that the hard-core structure provides a larger available volume at the interstitial site than the easy-core structure and, thus, facilitates the dissolution of C and O. More importantly, the addition of C/O in the dislocation significantly increases the Peierls stresses and double-kink formation enthalpies of screw dislocation in Mo, from 1.91 GPa and 1.18 eV for C/O-free dislocation to 5.63/4.69 GPa and 1.77/1.58 eV for C/O-saturated dislocation. Therefore, these interstitial solutes have a pinning effect on the dislocation motion, and this effect becomes stronger with higher segregating levels. This work reveals the profound effect of interstitial solutes on the properties of the dislocation core and provides a fundamental factor to account for the interstitial solutes-related phenomena in bcc metals.
A Study to Evaluate Pencil Grip Type, Hand Functions - Dexterity & Grip Strength in Children Using Tech for 2 or More Hours a Day

Background: These days, modern innovative technology plays a crucial part in our life. Touch screens has become the primary interaction method for smart phones due to their ability to combine input and output in a single interface. On the one hand, it has made our lives easier by allowing us to browse the internet, have essential conversations, and have a source of pleasure. Frequent use of technical devices without taking regular rest periods may result in cumulative trauma disorders to the neck, shoulders, hands and wrists. These disorders may occur because Smartphone, iPod etc. use typically requires thumb and finger interactions with the screen. Reports have shown that extended technology use accompanied by awkward wrist posture can lead to collective trauma disorders of the wrist joints, particularly when the wrist, hands, and fingers are overused. Repetitive static motion of the hands may also decrease blood supply and prevent nutrients from being delivered to muscles, thus leading to pain and muscle fatigue may result into poor hand function including reduced grip strength & poor dexterity. Children are attracted to smart phones because these devices can be used anywhere and contain games that are specifically matched to their ages. Numbers of studies have been done on Smartphone usage, hand writing performance & grip strength individually. However, the link between Smartphone addiction and grip strength and upper limb disability has been left unnoticed. Methodology: A cross sectional observational study was conducted to evaluate pencil grip type, hand dexterity & grip strength in children using technological devices for 2 or more hours a day dividing subjects into 2 groups. Group A: Children using technological devices for 2 or more hours a day. Group B: Children not using technological devices. Written consent was taken from the subjects and the subjects were made to understand the purpose of the study. Hand dexterity was evaluated using Functional Dexterity Test, Grip strength with hand held dynamometer & Pencil grip type was evaluated. Results: Data analysis was done using Graph Pad Prism 6. In Group A, Dynamic Tripod grasp was present in 19 subjects (61.29%) Five finger grasp in 0 subjects (0 %,), Thumb Wrap grasp in 1 subject (3.22%), Upright tripod grasp in 11 subject (35.48%). In Group B, Dynamic Tripod grasp was present in 26 subjects (83.87%) Five finger grasp in 0 subjects (0 %,), Thumb Wrap grasp in 1 subject (3.22%), Upright tripod grasp in 4 subjects (12.90%). The result showed significant difference for the functional dexterity test between Group A and Group B (t = 5.725 and p = 0.0001) & grip strength between Group A and Group B (t = 6.449 and p = 0.0001). Conclusion: Increased use of tech devices significantly affects Hand performance like Grip strength, Hand dexterity & Pencil grip pattern amongst children. Key words: Hand Dexterity, Grip Strength, Pencil Grip Type, Smart Phone Use, Functional Dexterity Test, Hand Writing Performance.
Draft Sequencing Crested Wheatgrass Chromosomes Identified Evolutionary Structural Changes and Genes and Facilitated the Development of SSR Markers

Crested wheatgrass (Agropyron cristatum), a wild relative of wheat, is an attractive source of genes and alleles for their improvement. Its wider use is hampered by limited knowledge of its complex genome. In this work, individual chromosomes were purified by flow sorting, and DNA shotgun sequencing was performed. The annotation of chromosome-specific sequences characterized the DNA-repeat content and led to the identification of genic sequences. Among them, genic sequences homologous to genes conferring plant disease resistance and involved in plant tolerance to biotic and abiotic stress were identified. Genes belonging to the important groups for breeders involved in different functional categories were found. The analysis of the DNA-repeat content identified a new LTR element, Agrocen, which is enriched in centromeric regions. The colocalization of the element with the centromeric histone H3 variant CENH3 suggested its functional role in the grass centromere. Finally, 159 polymorphic simple-sequence-repeat (SSR) markers were identified, with 72 of them being chromosome- or chromosome-arm-specific, 16 mapping to more than one chromosome, and 71 mapping to all the Agropyron chromosomes. The markers were used to characterize orthologous relationships between A. cristatum and common wheat that will facilitate the introgression breeding of wheat using A. cristatum.
Hydromechanical and Pore-Structure Evolution in Lime-Treated Kneading Compacted Soil

Hydromechanical performances and pore-structure evolution in in-situ lime-treated soil is influenced by the implemented methodology of execution. In-situ lime-treated soil experiences kneading action during soil compaction; however, little is investigated regarding the contribution of the kneading mechanism towards hydromechanical and pore-structure evolution. This study evaluates the evolution of Unconfined Compressive Strength (UCS), hydraulic conductivity
Study of Velocity Profile of a Converging Compound Channel Using ANSYS

The three dimensional ANSYS Fluent modeling of a converging type non-prismatic compound open channel is worked out in this B Tech research project. The flow calculations are performed by using VOF (volume of fluid model). The channel dimensions are large enough to allow a steady flow, so transient flow type is considered as the potential type for precise mimicking of experimental conditions. The comprehensive validation of the ANSYS simulated results against the experimental data and checking whether the non-prismatic compound channels can be investigated using this software; is the major purpose of this research project. Analysis of open channel flow with converging floodplain is very much important because estimation of potential hazards becomes easier.The floodplain of any natural river is generally a densely populated area due to the obvious reasons of transportation and irrigation facilities. Hence the design of flood combating strategies are essential. Taking observations on a site of flooded river is also a risky and costly task so, after validation; use of ANSYS simulated models are a safe and cheaper option to analyze the river parameters. In this project, the results gave an understanding about the interaction of fluids flowing in main channel and floodplain
Aesthetic perception of prosodic patterns as a factor in speech segmentation

This study addresses the hypothesis that the aesthetic appeal of linguistic features may influence their learnability and in turn their stability in a language. Focusing on prosodic patterns, we investigated the crucial baseline assumption that linguistic features like stress affect aesthetic appeal. Listeners’ liking, beauty and naturalness ratings of isochronous words and words with initially, medially or finally lengthened or shortened syllables revealed that, indeed, these patterns differed in their aesthetic appeal. Interestingly, the aesthetic appeal of prosodic patterns corresponded to their effectiveness for speech segmentation in other experiments, indicating a potential connection between aesthetics and language learning and opening up avenues for further research on the role of aesthetics in language acquisition and change.
Acoustic Emission Monitoring of High-Entropy Oxyfluoride Rock-Salt Cathodes during Battery Operation

High-entropy materials with tailorable properties are receiving increasing interest for energy applications. Among them, (disordered) rock-salt oxyfluorides hold promise as next-generation cathodes for use in secondary batteries. Here, we study the degradation behavior of a high-entropy oxyfluoride cathode material in lithium cells in situ via acoustic emission (AE) monitoring. The AE signals allow acoustic events to be correlated with different processes occurring during battery operation. The initial cycle proved to be the most acoustically active due to significant chemo-mechanical degradation and gas evolution, depending on the voltage window. Irrespective of the cutoff voltage on charge, the formation and propagation of cracks in the electrode was found to be the primary source of acoustic activity. Taken together, the findings help advance our understanding of the conditions that affect the cycling performance and provide a foundation for future investigations on the topic.
Multilayer Perceptrons as Weighted Conditional Knowledge Bases: an Overview

In this paper we report about the relationships between a multi-preferential semantics for defeasible description logics and a deep neural network model. Weighted knowledge bases for description logics are considered under a “concept-wise" preferential semantics, which is further extended to fuzzy interpretations and exploited to provide a preferential interpretation of Multilayer Perceptrons.
Fast computation method for electromagnetic scattering characteristics of unmanned air vehicle

A new electromagnetic scatter modeling method of simulation with measurement date is presented in detail. Unmanned air vehicle(UAV) is tested in the anechoic chamber, inlet and tail nozzle special part scattering point is extracted; Simultaneity applied the high-frequency approximated method, reflection at conducting surfaces is computed by using physical optics approximation; diffraction at edges by using physical theory of diffraction, electromagnetic scattering characters of targets simulation combining with the measurement date is fast obtained. The calculated results are consistent with the result from measurement, which assure validity of the method, high effectivity and accuracy.
Added value of EURO-CORDEX high-resolution downscaling over the Iberian Peninsula revisited – Part 1: Precipitation

Abstract. Over the years, higher-resolution regional climate model simulations have emerged owing to the large increase in computational resources. The 12 km resolution from the Coordinated Regional Climate Downscaling Experiment for the European domain (EURO-CORDEX) is a reference, which includes a larger multi-model ensemble at a continental scale while spanning at least a 130-year period. These simulations are computationally demanding but do not always reveal added value. In this study, a recently developed regular gridded dataset and a new metric for added value quantification, the distribution added value (DAV), are used to assess the precipitation of all available EURO-CORDEX hindcast (1989–2008) and historical (1971–2005) simulations. This approach enables a direct comparison between the higher-resolution regional model runs against their forcing global model or ERA-Interim reanalysis with respect to their probability density functions. This assessment is performed for the Iberian Peninsula. Overall, important gains are found for most cases, particularly in precipitation extremes. Most hindcast models reveal gains above 15 %, namely for wintertime, while for precipitation extremes values above 20 % are reached for the summer and autumn. As for the historical models, although most pairs display gains, regional models forced by two general circulation models (GCMs) reveal losses, sometimes around −5 % or lower, for the entire year. However, the spatialization of the DAV is clear in terms of added value for precipitation, particularly for precipitation extremes with gains well above 100 %.
Thermal performance evaluation of modified active greenhouse dryer

A prototype model of modified active greenhouse dryer has been designed, developed, and tested in no-load conditions at the Maulana Azad National Institute of Technology, Bhopal, India. The proposed dryer has been tested under two conditions: (1) with covered inside floor and (2) with uncovered floor. This study revealed that the covered floor condition of the greenhouse is favorable for drying due to higher raise in greenhouse temperature and decrease in its relative humidity.