Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence of Thromboembolic Complications Following Kidney Transplantation with Short and Extended Aspirin Prophylaxis: A Retrospective Single-Center Study

Background Aspirin prophylaxis has been associated with reduced graft-related thrombosis following kidney transplantation. Aspirin cessation, however, can increase risk of venous thromboembolic complications, including pulmonary thromboembolism and deep venous thrombosis. This single-center, retrospective, pre-post interventional study from Brisbane, Australia, aimed to compare the rate of thrombotic complications in 1208 adult kidney transplant recipients receiving postoperative aspirin for 5 days or >6 weeks. Material/Methods We enrolled1208 kidney transplant recipients who received 100 mg aspirin for 5 days (n=571) or >6 weeks (n=637) postoperatively. The primary outcome was venous thromboembolism (VTE) in the first 6 weeks after transplant, examined by multivariable logistic regression analysis. Secondary outcomes were renal vein/artery thrombosis, 1-month serum creatinine, rejection, myocardial infarction, stroke, blood transfusion, dialysis at day 5 and day 28, and mortality. Results Sixteen (1.3%) patients experienced VTE (5-day n=8, 1.4%; >6-week n=8, 1.3%; P=0.8). Extended aspirin duration was not independently associated with a reduction in VTE (OR 0.91, 95% CI 0.32–2.57; P=0.9). Graft thrombosis was rare (n=3, 0.25%). Aspirin duration was not associated with cardiovascular events, blood transfusion, graft thrombosis, graft dysfunction, rejection, or mortality. VTE was independently associated with older age (OR 1.09, 95% CI 1.04–1.16; P=0.002), smoking (OR 3.59, 95% CI 1.20–13.2; P=0.032), younger donor age (OR 0.96, 95% CI 0.93–1.00; P=0.036), and thymoglobulin use (OR 10.5, 95% CI 3.09–32.1; P≤0.001). Conclusions Extended-duration aspirin use did not significantly reduce the incidence of VTE in the first 6 weeks following kidney transplantation. An association was identified between anti-human thymocyte immunoglobulin and VTE, which requires further assessment.
Principles of Molecular Utility for CMS Classification in Colorectal Cancer Management

Simple Summary Colorectal cancer is the second most deadly tumor worldwide, despite the availability of screening plans and advanced treatment strategies. Molecular biomarkers predictive of prognosis have been identified, although there is currently limited knowledge of biomarkers predictive of the response to pharmacological treatment. In recent years, molecular classifications mainly able to predict colorectal cancer prognosis and recurrence risk have been proposed. The “consensus molecular subtype (CMS) classification” is the most known and has contributed to the understanding of genomic and epigenomic landscapes of colorectal cancer for better patient management. This classification categorizes colorectal cancer into four CMS categories (CMS1–4) that display different prognosis. This manuscript contextualized the CMS classification in different settings, discussing its relationships with precursor lesions, tumor immunophenotype, and gut microbiota, as well as its role in predicting prognosis and/or response to pharmacological treatments, as a crucial step towards precision medicine. Abstract Colorectal cancer (CRC) is the second cause of cancer-related deaths in both sexes globally and presents different clinical outcomes that are described by a range of genomic and epigenomic alterations. Despite the advancements in CRC screening plans and treatment strategies, the prognosis of CRC is dismal. In the last two decades, molecular biomarkers predictive of prognosis have been identified in CRC, although biomarkers predictive of treatment response are only available for specific biological drugs used in stage IV CRC. Translational clinical trials mainly based on “omic” strategies allowed a better understanding of the biological heterogeneity of CRCs. These studies were able to classify CRCs into subtypes mainly related to prognosis, recurrence risk, and, to some extent, also to treatment response. Accordingly, the comprehensive molecular characterizations of CRCs, including The Cancer Genome Atlas (TCGA) and consensus molecular subtype (CMS) classifications, were presented to improve the comprehension of the genomic and epigenomic landscapes of CRCs for a better patient management. The CMS classification obtained by the CRC subtyping consortium categorizes CRC into four consensus molecular subtypes (CMS1–4) characterized by different prognoses. In this review, we discussed the CMS classification in different settings with a focus on its relationships with precursor lesions, tumor immunophenotype, and gut microbiota, as well as on its role in predicting prognosis and/or response to pharmacological treatments, as a crucial step towards precision medicine.
AlGaN/GaN HEMTs on Silicon With a Graded-AlGaN Back-Barrier for RF Applications

In this study, we report on the electrical characteristics of AlGaN/GaN HEMT fabricated on a GaN-on-Si buffer scheme with a reverse-graded AlGaN back-barrier. Transistors exhibited a maximum DC drain current of 0.8 A/mm with a peak transconductance of 280 mS/mm. Devices exhibited off-state breakdown voltage greater than 100V, indicating good channel control even without compensation dopants. The current collapse in these devices was approximately 12% under drain-lag pulsed-IV measurements, indicating minimal trapping in this buffer scheme. RF small-signal measurements yielded peak ft/fmax figures of 31/72 GHz, respectively. A peak output power of 2.36 W/mm was obtained in pulsed load-pull measurements at 4 GHz with a Power-Added-Efficiency (PAE) of 18.1%.
Hopf Algebras from Branching Rules

Below we work out the algebra structure of some Hopf algebras which arise concretely in restricting representations of the symmetric group to certain subgroups. The basic idea generalizes that used by Adams [1] for H *(BSU). The question arose in discussions with H. K. Farahat. I would like to thank him for his interest in the work and to acknowledge the usefulness of several stimulating conversations with him. 1. Review and statement of results. A homogeneous element of a graded abelian group will have its gradation referred to as its dimension. In all such groups below there will be no non-zero elements with negative or odd dimension. A graded algebra (resp. coalgebra) will be associative (resp. coassociative), strictly commutative (resp. co-commutative) and in dimension zero will be isomorphic to the ground ring F, providing the unit (resp. counit). We shall deal amost entirely with F = Z or F = Z/p for a prime p; the cases F = 0 or a localization of Z will occur briefly. In every case, the component in each dimension will be a finitely generated free F-module, so dualization works simply.
Self-Supervised Antipodal Grasp Learning With Fine-Grained Grasp Quality Feedback in Clutter

It is a challenging goal in robotics to make a robot grasp like a human being in a cluttered environment. Self-supervised grasp learning (SGL) is one of the most promising approaches to human-like robotic grasp. However, due to inadequate feedback on grasp quality, almost existing SGL methods are coarse-grained. This article presents a fine-grained antipodal grasp learning (FAGL) method with augmented learning feedback. First, an indicator called antipodal degree of a grasp (ADG) is designed as a non-increasing monotonous function for the fine-grained evaluation of grasp quality according to the disturbance incurred by a grasp to the surroundings in the image space. Next, we design a restorative sampling strategy to collect antipodal grasp samples and propose a refined affordance network to generate grasp affordance maps for FAGL's decision of grasp policies. Finally, in grasping actual metal workpieces, FAGL outperforms its peers in grasp success rate and ADG in cluttered scenarios by reducing the grasp disturbance to the surroundings.
Alterations in the Glycan Composition of Serum Glycoproteins in Attention-Deficit Hyperactivity Disorder

Changes in protein glycosylation are associated with most biological processes, and the importance of glycomic analysis in the research of disorders is constantly increasing, including in the neurodevelopmental field. We glycoprofiled sera in 10 children with attention-deficit hyperactivity disorder (ADHD) and 10 matching healthy controls for 3 types of samples: whole serum, sera after depletion of abundant proteins (albumin and IgG), and isolated IgG. The analytical methods used were a lectin-based glycoprotein microarray enabling high-throughput glycan analysis and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) as a standard method for the identification of glycan structures. For microarray analysis, the samples printed on microarray slides were incubated with biotinylated lectins and detected using the fluorescent conjugate of streptavidin by a microarray scanner. In the ADHD patient samples, we found increased antennary fucosylation, decreased di-/triantennary N-glycans with bisecting N-acetylglucosamine (GlcNAc), and decreased α2-3 sialylation. The results obtained by both independent methods were consistent. The study’s sample size and design do not allow far-reaching conclusions to be drawn. In any case, there is a strong demand for a better and more comprehensive diagnosis of ADHD, and the obtained results emphasize that the presented approach brings new horizons to studying functional associations of glycan alterations in ADHD.
A measurement of the CKM angle from studies of DK∏ Dalitz plots

Various measurements of quantities relating to B0 (s) → DK ±π∓ decays are reported from analyses building towards a measurement of the CKM angle γ. The first observation of the decay B0 s → D0K−π+ is reported. Based on a data sample corresponding to an integrated luminosity of 1.0 fb−1 of pp collision data recorded by the LHCb detector, the branching fraction relative to that of the topologically similar decay B0 → D0π+π− is measured to be B ( B0 s → D0K−π+ ) B ( B0 → D0π+π− ) = 1.18± 0.05 (stat.)± 0.12 (syst.) . In addition, the relative branching fraction of the decay B0 → D0K+π− is measured to be B ( B0 → D0K+π− ) B ( B0 → D0π+π− ) = 0.106± 0.007 (stat.)± 0.008 (syst.) . The resonant substructures of B0 s → D0K−π+ and B0 → D0K+π− decays are studied using a data sample corresponding to an integrated luminosity of 3.0 fb−1 of pp collision data recorded by the LHCb detector. In B0 s → D0K−π+ decays, an excess at m(D0K−) ≈ 2.86 GeV/c2 is found to be an admixture of spin-1 and spin-3 resonances. This is the first observation of a heavy flavoured spin-3 resonance, and the first time that any spin-3 particle has been seen to be produced in B decays. The masses and widths of the new states and of the D∗ s2(2573) − meson are measured as part of this analysis, giving the most precise determinations to date, while the masses and widths of the D∗ 0(2400) − and D∗ 2(2460) − resonances are measured from the analysis of B0 → D0K+π− decays. The complex amplitudes and fit fractions for all components included in the two amplitude models are also measured. Finally, a first determination of γ from an amplitude analysis ofB0 → DK+π− decays is reported based on measurements of the Cartesian parameters x± = rB cos (δB ± γ) , y± = rB sin (δB ± γ) .
Combination of Bacteriophages and Antibiotics for Prevention of Vascular Graft Infections—An In Vitro Study

(1) Background: Implant-associated bacterial infections are usually hard to treat conservatively due to the resistance and tolerance of the pathogens to conventional antimicrobial therapy. Bacterial colonization of vascular grafts may lead to life-threatening conditions such as sepsis. The objective of this study is to evaluate whether conventional antibiotics and bacteriophages can reliably prevent the bacterial colonization of vascular grafts. (2) Methods: Gram-positive and Gram-negative bacterial infections were simulated on samples of woven PET gelatin-impregnated grafts using Staphylococcus aureus and Escherichia coli strains, respectively. The ability to prevent colonization was evaluated for a mixture of broad-spectrum antibiotics, for strictly lytic species-specific bacteriophage strains, and for a combination of both. All the antimicrobial agents were conventionally tested in order to prove the sensitivity of the used bacterial strains. Furthermore, the substances were used in a liquid form or in combination with a fibrin glue. (3) Results: Despite their strictly lytic nature, the application of bacteriophages alone was not enough to protect the graft samples from both bacteria. The singular application of antibiotics, both with and without fibrin glue, showed a protective effect against S. aureus (0 CFU/cm2), but was not sufficient against E. coli without fibrin glue (M = 7.18 × 104 CFU/cm2). In contrast, the application of a combination of antibiotics and phages showed complete eradication of both bacteria after a single inoculation. The fibrin glue hydrogel provided an increased protection against repetitive exposure to S. aureus (p = 0.05). (4) Conclusions: The application of antibacterial combinations of antibiotics and bacteriophages is an effective approach to the prevention of bacteria-induced vascular graft infections in clinical settings.
Search for prompt neutrinos with AMANDA-II

The investigation performed in this work aims to identify and disentangle the signal of prompt neutrinos from the inclusive atmospheric spectrum. We have analysed data recorded in the years 2000-2003 by the AMANDA-II detector at the geographical South Pole. After a tight event selection, our sample is composed of about 4 · 103 atmospheric neutrinos. Prompt neutrinos are decay products of heavy quark hadrons, which are produced in the collision of a cosmic ray particle with a nucleon in the atmosphere. The technique used to recognise prompt neutrinos is based on a simulated information of their energy spectrum, which appears harder than that of the conventional component from light quarks. Models accounting for different hadron production and decay schemes have been included in a Monte Carlo simulation and convoluted with the detector response, in order to reproduce the different spectra. The background of conventional events has been described with the Bartol 2006 tables. The energy spectrum of our data has been reconstructed through a numerical unfolding algorithm. The reconstruction is based on a Monte Carlo simulation and uses as an input three parameters of the neutrino track which are correlated with the energy of the event. Numerical regularisation is introduced to achieve a result free of unphysical oscillations, typical unfortunate feature of unfolding. The reconstructed data spectrum has been compared with different predictions using the model rejection factor technique. The prompt neutrino models differ in the choice of the hadron interaction model, the set of parton distribution functions and the numerical parameterisation of the fragmentation functions describing the transition from quark to hadrons. Here we considered mainly three classes of models, known in the literature as the Recombination Quark Parton Model, the Quark Gluon String Model and the Perturbative QCD model. Upper limits have been set on the expected flux predictions, based on our observations. The quark gluon string model seems to be disfavoured at 90% confidence level. Theoretical uncertainties strongly affect the predictions, as the deep inelastic QCD scattering process contains quantities that cannot measured at high Q2 and small x. Systematics affecting the measurements are partly ascribed to the ice structure and partly to the detector efficiency. For the former, we use a reference description of the optical properties of the South Pole glacier. As for the latter, the acceptance of the photomultipliers has been estimated in this work with a geometrical method based on the probability of detecting photon at a given distance. Chances to improve upon the current limits are assigned to the future large neutrino telescopes, which will allow to increase the sensitivity to both prompt and extraterrestrial neutrinos. this thesis is dedicated to the two girls who won’t be here to read it . thank you mum, thank you nan
A Case for Doxycycline as an Effective Treatment for Confluent and Reticulated Papillomatosis (CARP)

Confluent and reticulated papillomatosis (CARP) is a rare keratinization disorder that presents with asymptomatic, reticulated papules coalescing into plaques, which adversely affect, most often, young black persons. Minocycline is considered the drug of choice, but it is not without its host of potential side effects, including drug hypersensitivity, drug-induced lupus/vasculitis/hepatitis, blue-gray skin hyperpigmentation, acute eosinophilic pneumonia, pseudotumor cerebri, and vestibular instability, among others. Alternatively, doxycycline might be considered as another first-line agent for CARP as it can effectively clear lesions while offering a more favorable side effect profile in select patients. Herein, we present a case of CARP successfully resolved with doxycycline after a protracted treatment history of topical and oral antifungal medications for suspected tinea versicolor (TV).
Should Poland join the euro area? The challenge of the boom-bust cycle

The article makes references to the existing cost-benefit analyses on adopting the euro in Poland and other new member states of the EU. In general, they considered a decrease in the cost of capital to be among the crucial benefits of adopting the common currency. As a result, the costs of a credit boombust cycle, to which adoption of the euro may lead, were at best underestimated. The authors discussed the possible solutions to mitigate the risk of boom-bust cycles and concluded that although they are conceptually simple, their effective implementation may be difficult, mostly due to political pressures. To overcome the feasibility problem, the power over undertaking macro prudential measures should be delegated to the central bank. Its past performance in stabilising the economy (at least until recently) suggests that it could make a good use of such a power. Furthermore, adopting the euro would resolve the problem of the ‘difficult cohabitation’ of monetary and macro prudential policy that such a delegation would otherwise create.
Factors Associated with Gastroenteritis Disease among Children Age 2-5 Years in Qaladze and Ranya City

Acute gastroenteritis is a major cause of pediatric morbidity and death worldwide, with high healthcare utilization, ongoing practice variation, and significant family burden, especially in developing countries, and young children under the age of five are the most vulnerable. The objectives of the study are to: To assess the factors associated with gastroenteritis in children 2-5 years of age and also to investigate if there is a correlation between socio-demographic data with some of the factors of gastroenteritis A quantitative /descriptive study was conducted, with A non-probability /convenience sampling, The sample size was (111) children who had gastroenteritis and were admitted in Ranya maternity and pediatric teaching hospital and pediatric ward in Shahidan Qaladze Teaching Hospital. The data was collected by modifying the questionnaire that was asked from the patient’s parents by interview (face to face) method. The results of the study indicate that most of the cases were between the age (of 24-28) months 22%, (29-33) months 14%, (32-38) months14% and (59and more) months 28% with the (Mean =42) months. The male was more affected (58%) than the female (42%). Most of the patients were from urban areas (67%). According to the findings, there is a correlation between BMI (body mass index) with gastroenteritis because the P-value is less than 0.05, (P-value =0.04566), there is a significant correlation between Type of feeding and eating Type with Gastroenteritis because the p-value for both of these correlations is less than (0.05), the p-value of correlation between Feeding type and Gastroenteritis is (0.0374). There is a correlation between making the water safer to drink with gastroenteritis because the P-value less than 0.05, and the P-value is (0.0423). Children under 5 years of age are vulnerable to suffering gastroenteritis, the factors, including BMI (body mass index) ،methods that are used to clean water safer, feeding type, and eating type; are those factors that make clients vulnerable to suffer gastroenteritis.
Exploring spatial dependence in area-level random effect model for disaggregate-level crop yield estimation

This paper describes an application of small area estimation (SAE) techniques under area-level spatial random effect models when only area (or district or aggregated) level data are available. In particular, the SAE approach is applied to produce district-level model-based estimates of crop yield for paddy in the state of Uttar Pradesh in India using the data on crop-cutting experiments supervised under the Improvement of Crop Statistics scheme and the secondary data from the Population Census. The diagnostic measures are illustrated to examine the model assumptions as well as reliability and validity of the generated model-based small area estimates. The results show a considerable gain in precision in model-based estimates produced applying SAE. Furthermore, the model-based estimates obtained by exploiting spatial information are more efficient than the one obtained by ignoring this information. However, both of these model-based estimates are more efficient than the direct survey estimate. In many districts, there is no survey data and therefore it is not possible to produce direct survey estimates for these districts. The model-based estimates generated using SAE are still reliable for such districts. These estimates produced by using SAE will provide invaluable information to policy-analysts and decision-makers.
Novel stable crystalline phase for the Stillinger-Weber potential

Tetrahedral liquids such as silicon, germanium, carbon, water, and silica are an important class of materials not only for industrial applications but also for our understanding of nature. The Stillinger-Weber potential is one of the most popular models for computer simulations of these systems with tetrahedral coordination, with the directionality of the interactions introduced via a three-body repulsive term which promotes locally tetrahedral arrangements. This approach has been extended to various tetrahedral liquids, providing valuable insight into the physics of group XIV elements and more recently water. Perhaps surprisingly, a consistent thermodynamic picture of this class of models is still lacking despite their widespread usage. Here we fill this gap by computing equilibrium phase diagrams for the silicon and water parametrizations and report a novel crystal structure which dominates the models' phase diagram at intermediate and high pressure, and thus warrants further theoretical and numerical investigation. Our results redefine the phase behavior of an important class of tetrahedrally coordinated systems, and also suggest that a more stringent test for simulation models is the ability to select the experimentally relevant crystalline phases, as opposed to just reproducing their mechanical stability.