Miracle-dz/UniFAR-FTUs huggingface dataset:
Electronic Screening to Support Measurement Based Care: Examples from the Field

Abstract Background Measurement-based care (MBC) is associated with improved patient outcomes, but is seldom fully implemented. Electronic self-report screening systems may help overcome some obstacles associated with implementing MBC. One such program, eScreening, provides customized and automated self-report mental and physical health screening via mobile tablet for veterans seen in Veterans Health Administration (VHA) settings and by web browser for patients seen remotely by telemedicine. We aimed to describe how electronic health screening systems can support the implementation of measurement-based behavioral healthcare. Methods We collected descriptive data on the use of eScreening, including clinical settings, measures used, and frequency of use; and present a brief case composite example. Results eScreening was used in multiple VHA clinical programs to administer validated symptom severity measures at baseline and regular intervals during treatment. The case composite example describes a Veteran referred to the PTSD clinic where he was treated with Cognitive Processing Therapy. eScreening was used routinely to track mental health symptoms, promote collaborative dialogue, and inform treatment progress. Conclusion Electronic self-report screening systems can support the implementation of MBC by facilitating the process of routine symptom collection/monitoring, informed decision-making, objective evaluation of treatment outcomes, and collaborative care in behavioral healthcare settings.
Beyond intersubjective validity: recent empirical investigations into the nature of aesthetic judgment

According to a longstanding tradition in philosophy of art, people spontaneously attribute universal, intersubjective validity to their aesthetic judgments. In this chapter, I discuss recent empirical evidence against this claim. I then present the results of two new studies that extend these findings by showing that, far from being intersubjectively valid, the truth-value of aesthetic judgment can also vary in function of (i) the etiology of these judgments, and (ii) the person they are directed to.
REcovery and SURvival of patients with moderate to severe acute REspiratory distress syndrome (ARDS) due to COVID-19: a multicentre, single-arm, Phase IV Itolizumab Trial: RESURRECT

Objective: To evaluate safety and efficacy of Itolizumab in hospitalized COVID-19 patients with PaO2/FiO2 ratio (PFR) [≤]200 requiring oxygen therapy. Design: A multicentre, single-arm, Phase-4 study with a treatment period of 30-Days and an extended follow-up period of 90-Days. Methods: Hospitalized adult patients (n=300) with SARS-CoV-2 infection, with PFR [≤]200, oxygen saturation [≤]94% and [≥]1 elevated inflammatory markers were included from 17 COVID-19 specific tertiary hospitals in India. Patients received Itolizumab infusion 1.6 mg/kg and were assessed for 1-month and then followed up to Day-90. Results: Day-30 post-treatment safety/efficacy results and Day-90 mortality results are presented. Primary outcome measures: incidence of severe acute infusion-related reactions (IRRs) ([≥]Grade-3) was 1.3% and mortality rate at 1-month was 6.7% (n=20/300). Key secondary analyses: Mortality rate at Day-90 was 8.0% (24/300). 91.7% patients came off the oxygen therapy within Day-30 of treatment. By Day-7, most patients had stable/improved SpO2 without increasing FiO2. Mean PFR improved by 50% by Day-7 (p<0.001) and the trend remained consistent till Day-30. Median time of recovery was 8 days. Cumulatively, at Day-30, 260(86.7%), 256(85.3%), 132(44.0%), 113(37.6%) and 32(10.7%) patients showed >1-point, >2-point, >3-point, >4-point and 5-point improvement on the modified COVID-19 8-point ordinal scale and worsening of symptoms by >1 point, >2 points and 3-points was seen in 26(8.7%), 20(6.7%) and 6(2.0%) patients, respectively. CRP, D-dimer, LDH and serum ferritin levels significantly decreased (p[≤]0.01) compared with baseline. IL-6 and TNF levels also decreased 48-hours post-infusion. Overall, 123 treatment-emergent adverse events (TEAEs) were reported in 63 patients, most being Grades 1-3. Most common TEAEs were IRRs and lymphopenia; most common serious TEAEs were septic shock, worsening of ARDS and respiratory failure. No deaths were attributable to Itolizumab. Conclusion: Itolizumab shows no new safety concerns and suggests a mortality and recovery benefit at 1-month in hospitalized COVID-19 patients requiring oxygen therapy.
Incidence of Hepatocellular Carcinoma in Patient with Elevated Alpha Fetoprotein before DAAS

Background: Management of chronic infection with hepatitis C virus (HCV) with direct acting antivirals (DAAs) agents achieves high virological response. Recently, there is a matter of controversy about occurrence of hepatocellular carcinoma (HCC) following those agents. Objective: This study aimed to evaluate the efficacy of alpha fetoprotein (AFP) in development of HCC following DAAs therapy. Patients and methods: two hundred patients with chronic HCV infection who were eligible for DAAs therapy were recruited. Those patients were followed up for one year following therapy to detect development of HCC. Patients were grouped into either with normal AFP (100 patients) or high AFP (100 patients). Results: Majority (84%) of patients were males with overall mean age of 43.87±12.76 years. There were no significant differences between both groups of patients as regard baseline data. With exception of 4% of patients, all of them reached the sustained virological response (SVR). Frequency of HCC detection was higher among those patients with high AFP (9 (9%) vs 1 (1%); P< 0.001). We found that liver cirrhosis; FIB-4, APRI and AFP were predictors for HCC. AFP had the best diagnostic accuracy for prediction of HCC following DAAs Conclusion: Patients who received DAAs for HCV infection should be regularly screened for development of HCC.
Qualitative and Quantitative Variability of Flora and Fauna along Rosetta Branch of the River Nile, Egypt

Nile River is the lifeline supplying water to millions of people. It extends into the Mediterranean Sea by its two main branches, the Rosetta and the Damietta, which are flowing through the Nile delta wetland (Badr et al., 2006). The Rosetta branch is receiving wastes discharged by agricultural, industrial, and domestic activities. A total of two pollution sources affecting the water quality at the Rosetta branch, firstly are the ARTICLE INFO Article History: Received: March 8, 2021 Accepted: June 28, 2021 Online: Aug. 30, 2021 _______________
Do Resource-Rich Provinces Perform Lower Democratization Progress? Estimating Oil Impact on Democracy Indicators in Indonesia

This study examined whether oil dependence affected democracy quality by referring to provincial-level data in Indonesia. While physical quantity production was used to measure oil dependence, democracy was measured based on the Indonesian Democracy Index (IDI). Static panel data analysis was employed to control unobserved time-invariant characteristics of each province, including a robust Driscoll and Kraay (D-K) standard error model for the general forms of cross-sectional dependence when dealing with panel observation. The results showed that oil-dependent provinces tended not to have weak democratic qualities. The effects were also robust when democracy was separated into three main elements of the IDI: political rights, civil liberties, and democratic institutions, or when an alternative measure of dependency was used. Interestingly, this study found that oil dependence had a stronger effect on democracy in provinces with a lack of oil than in Sumatra and Kalimantan, globally known as dominant resource locations.
Diabetic patients awareness toward hypoglycemia attacks in Al Jouf region, Saudi Arabia

Background: Hypoglycemia is a condition characterized by a drop in serum glucose concentration of ≤70 mg/ dl. A steady glucose supply is essential for brain physiological functions. Type of medications used for diabetic therapy, errors in dose or timing of insulin, prior history of hypoglycemic episodes, recurrent history of hypoglycemia, and delayed diagnosis of diabetes are the major risk factors associated with hypoglycemia. We aimed to assess diabetic patients’ awareness toward hypoglycemia attacks and explore the relationship between the level of awareness and different socio-demographic factors. Methods: A cross sectional study was carried out in Al Jouf Region, Saudi Arabia between August to November 2021. A convenient non-probability sampling technique was employed to collect data from the participants. Data were coded, entered, and analyzed using the Statistical Package for Social Science version 23. Results: A total of 273 respondents were included in the study with 52.4% of them being females. The majority of the participants were in the age range of 26 to 35 years and 84.6% of them were taking medication for diabetes management. Injectable insulin was used by 55.3%. Family/friends/acquaintances were the most common (42.5%) source of participant’s knowledge about hypoglycemic attacks. Poor awareness about hypoglycemic attacks was observed among 62.6% participants. Level of awareness was significantly affected by gender, age, educational level, marital status, and monthly income with p -values = 0.018, 0.015, <0.001, <0.001, and <0.001 respectively. Conclusions: Good level of awareness regarding hypoglycemia risk factors, symptoms, complication, and treatment was found in more than half of respondents and few knowledge gaps warrants further attention.
Antecedents of Personal Norms and Social Media Information towards Biofuel Purchase Intention in Special Region of Yogyakarta

This examination means to re-analyze the effect of the ascription of responsibility, awareness of the consequences, personal norms, and social media information on biofuel purchase intentions in the Special Region of Yogyakarta. This study tries to re-examine the merger of two theories: Theory of Planned Behavior (TPB) and The Norm Activation Model (NAM). The results showed that the ascription of responsibility and awareness of consequences affected personal norms. This study also indicates that personal norms and social media information positively and significantly impact biofuel purchase intentions. The awareness variable is the most dominant variable from the data processing results from the consumer’s point of view. Meanwhile, the personal norm variable is the most dominant from the industrial point of view of data processing. This investigation’s practical implication is to give industry, the government, and the wider community to jointly promote one of the government programs, switching from non-renewable fuels to renewable fuels.
Islamic Corporate Governance and The Performance of Sharia Banks

This study analyzes the influence of Islamic Corporate Governance (ICG) on the performance of sharia banks. This study uses a panel data regression analysis tool. The research sample includes 12 Islamic banks from 2009 to 2019. Based on the 2020 Islamic banking statistics, the number of sharia banks is 12. The sampling technique used is the convenience sampling method. The results showed that Islamic corporate governance has a positive effect on the performance of sharia banks. ICG has a positive effect on financial performance and managerial behavior. Reporting quality and profits are better after implementing strict ICG. Similarly, the size of the bank as a control variable has a positive effect on the performance of Islamic banks.
Inorganic Elements of Mangium Stem (Acacia mangium Willd) from Different Provenanc

This study aimed to investigate the ash content and concentrations of inorganic elements present in the stem of Acacia mangium. The tree samples (24 years) were collected from five different provenances (Sidei, West of Morehead, Daintree, Ellerbeck, and El Arish). Meanwhile, the disc samples were obtained from the trunk of each tree on the lower parts. The samples were collected from four radial positions (bark, sapwood, outer heartwood, inner heartwood), and the ash and insoluble acid contents were determined. Furthermore, the concentration of 5 elements (Ca, Mg, Fe, Mn, K, and Na) was measured by Atomic Absorption Spectrophotometry (AAS). The interaction of provenance and radial position factors affected ash and potassium contents. Also, acid insoluble ash and calcium contents showed a provenance factor effect. The barks obtained from the tree samples contained the highest concentrations of ash content and most of the elements. The wood and bark of El-Arish provenance showed the lowest (0.50~0.72%) and highest levels (4.75%) of ash content respectively. Furthermore, the highest amount of insoluble acid ash (3075 ppm) and calcium (4513 ppm) content was also measured in samples of El-Arish provenance, and radial position factor was a significant source of variation for Ca, Mg, Na, and Mn concentrations. Except Mg, the inner and outer portions of the heartwood mostly showed no significant difference in unprecedented element concentrations. Ash content was positively correlated with Ca in sapwood (r=0.39) and Mn in bark (r=0.54). In addition, moderate correlations were observed between Mg and Ca in heartwood (r=0.63) and bark (r=0.54) tissues. For ash and silica content, the comparatively low concentration on samples from El-Arish provenance are good options to improve wood quality for breeding programs.
Indonesia: Jokowi Sidelines Democracy

Abstract:Democracy in Indonesia is under attack from within. Despite high levels of democratic commitment from voters and elites, President Joko Widodo has sidelined democracy for the sake of economic development, his avowed main priority. Under his tenure, free elections have been threatened, civil liberties have declined, corruption fighters and legislative checks weakened, and the armed forces’ role in civilian affairs has grown. Elected local officials whose terms end before the 2024 elections will be replaced by Jokowi’s appointees. The large number of offices contested in those elections will unnecessarily and dangerously burden election officials.
Respiratory syncytial virus in pediatric influenza‐like illness cases in Lombardy, Northern Italy, during seven consecutive winter seasons (from 2014–2015 to 2020–2021)

Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract illness in young children and can also cause influenza‐like illness (ILI). Here we investigated the epidemiological features of RSV infection in pediatric ILI cases in Lombardy (a region in Northern Italy accounting nearly 10 million inhabitants) from 2014–2015 to 2020–2021 winter seasons.
Practical Needs in Assessing Response to Therapy in Operated Brain High Grade Glioma According to Response Assessment in Neuro-Oncology Criteria

Background: Tumors known as gliomas begin in the brain or spine's glial cells and might spread throughout the body. An effort was made to improve tumor response evaluation and end point selection through the Response Assessment in Neuro-Oncology (RANO) working group. Objective: To standardize the assessment method and results reporting by applying MRI-RANO criteria in detecting glioma response to surgical treatment. Patients and Methods: This was a prospective cohort study included 12 patients (4 males and 8 females) whose mean age was 53.6 ± 15.1years. Included patients are those who were operated and pathologically proved as brain glioma grade IV (GBM). They underwent post-operative MRI within 48 hours and are available for follow up MRI after 3 months. Imaging modalities applied in both MRI exams were conventional magnetic resonance imaging, MRI diffusion weighted images, and contrast imaging. RANO criteria were applied. Results: According to RANO criteria, none of the lesions had pseudo response or pseudo progression. However, two thirds (66.7%) had progressive disease and one third (33.3%) had complete response. There was statistically significant association between MRI findings 3 months postoperative and RANO criteria as patients with compete response had statistically significant decrease on measurable solid components, diffusion restriction, post contrast enhancement and all lesions had grade I edema with no mass effect or midline shift compared to patients with progressive disease. 4 cases that showed complete response category had fulfilled all the RANO criteria, while 8 cases with category progressive disease had fulfilled more than one of the described RANO criteria. Conclusion: RANO criteria are an effective tool to be used in interpretation of MRI for follow-up of surgically operated glioma patients to detect their response.
Thermal tolerance and vulnerability to climate change in subterranean species: a case study using an Iberian endemic pseudoscorpion

Scientists are renewing their efforts to predict the impact of climate change on biodiversity. Subterranean environments represent ideal systems to study the effect of global change in species with poor dispersal capabilities. We assess the vulnerability to climate change of the subterranean pseudoscorpion Neobisium (Blothrus) vasconicum vasconicum (Nonídez, 1925) (Neobisiidae). Thermal tolerance was measured using two complementary estimates of upper thermal limits: (i) from thermal conditions of the localities in which the species occurs (realised upper thermal limit, RUTL), and (ii) from experimentally determined thermal tolerance data (physiological upper thermal limit, PhUTL). Then, thermal safety margins (TSM) were calculated for all known localities for current and future climatic conditions, using the thermal limits from both approaches. The physiological thermal limit (PhUTL = 17.57°C) was 3.27°C higher than that obtained from the distributional and climate data (i.e., the hottest cave in which the species occurs; RUTL = 14.3°C). Regarding TSM, the future temperature (2070; RCP 8.5) of a half of the caves will be higher than the RUTL and in none of them, it would exceed the average PhUTL. This indicates that the species could have some physiological capacity to cope with warming temperatures in situ. We hypothesize that the most realistic upper thermal limit of the species could be between the RUTL and PhUTL. This study shows that complementary approaches to estimate thermal tolerance could provide more accurate predictions of the capacity to face climate change, not only in subterranean species, but also in poor dispersal species.
Unpacking the blocking effect: Syntactic prominence and perspective-taking in antecedent retrieval in Mandarin Chinese

In the linguistics literature, it is generally accepted that the non-local use of the bare reflexive ziji in Mandarin Chinese is sensitive to perspective centers. The introduction of a local first-person pronoun encoding the comprehender’s perspective is assumed to block non-local binding (i.e. make it unavailable), a phenomenon called the blocking effect. However, it is not yet clear whether the blocking effect is absolute, nor whether the syntactic prominence of the blocking pronoun influences the strength of blocking. In this study, we report two sets of offline and online experiments to examine the blocking effect associated with ziji. By comparing the forced choice judgment results in Experiments 1 and 2, we find that syntactically prominent subject blockers lead to stronger blocking compared to object blockers, and that the strength of the blocking effect can be modulated by verb semantics. Furthermore, only subject blockers caused blocking during incremental real-time processing while object blockers did not. The results of these experiments have implications for both the linguistic formulation of the blocking effect and for sentence processing models.
The role of neutrophils in the pathogenesis of ischemic stroke

Background. Immune responses and inflammation play an important role in the pathogenesis of ischemic stroke.Aim. To analyze the involvement of neutrophils in the pathogenesis of ischemic stroke.Results. Data on the contribution of neutrophil granulocytes to the development of local sterile inflammation and secondary brain injury in acute ischemic stroke were summarized. Mechanisms of neutrophil influence on thrombosis, neutrophil extracellular trap formation (NETosis), protease release, and direct interaction with platelets with subsequent formation of platelet-leukocyte aggregates were discussed. Available information on the effectiveness of reperfusion therapy and an association of changes in neutrophil activity with development of infectious complications of stroke were presented. In addition, research data were presented on the contribution of neutrophils to atherogenesis, which is one of the most important etiological factors in ischemic stroke. The review showed that the contribution of neutrophils to the pathogenesis of ischemic stroke is associated with implementation of their secretory, regulatory, and phagocytic functions, as well as with NETosis.Conclusion. It was shown that neutrophils are involved in the pathogenesis of ischemic stroke and modulate a response to treatment.
Genetic basis of growth, spring phenology, and susceptibility to biotic stressors in maritime pine

Forest ecosystems are increasingly challenged by extreme events, for example, drought, storms, pest attacks, and fungal pathogen outbreaks, causing severe ecological and economic losses. Understanding the genetic basis of adaptive traits in tree species is of key importance to preserve forest ecosystems, as genetic variation in a trait (i.e., heritability) determines its potential for human‐mediated or evolutionary change. Maritime pine (Pinus pinaster Aiton), a conifer widely distributed in southwestern Europe and northwestern Africa, grows under contrasted environmental conditions promoting local adaptation. Genetic variation at adaptive phenotypes, including height, spring phenology, and susceptibility to two fungal pathogens (Diplodia sapinea and Armillaria ostoyae) and an insect pest (Thaumetopoea pityocampa), was assessed in a range‐wide clonal common garden of maritime pine. Broad‐sense heritability was significant for height (0.219), spring phenology (0.165–0.310), and pathogen susceptibility (necrosis length caused by D. sapinea, 0.152; and by A. ostoyae, 0.021, measured on inoculated, excised branches under controlled conditions), but not for pine processionary moth incidence in the common garden. The correlations of trait variation among populations revealed contrasting trends for pathogen susceptibility to D. sapinea and A. ostoyae with respect to height. Taller trees showed longer necrosis length caused by D. sapinea while shorter trees were more affected by A. ostoyae. Moreover, maritime pine populations from areas with high summer temperatures and frequent droughts were less susceptible to D. sapinea but more susceptible to A. ostoyae. Finally, an association study using 4227 genome‐wide SNPs revealed several loci significantly associated with each trait (range of 3–26), including a possibly disease‐induced translation initiation factor, eIF‐5, associated with needle discoloration caused by D. sapinea. This study provides important insights to develop genetic conservation and breeding strategies integrating species responses to biotic stressors.