Miracle-dz/UniFAR-FTUs huggingface dataset:
Low Incidence of Acute Antibody-Mediated Rejection after HLA Desensitization in Living Donor Kidney Transplant Recipients

Desensitization allows the performance of human leukocyte antigen (HLA)-incompatible transplants. However, the incidence of acute rejection (AR) is high. This study aims to analyze the incidence of AR after transplantation with HLA-incompatible living donors in patients who underwent desensitization. Patients were immunosuppressed with tacrolimus, mycophenolic acid derivatives, and steroids after being desensitized with rituximab, plasma exchange, and/or immunoadsorption with specific cytomegalovirus immunoglobulins. A negative complement-dependent cytotoxicity or flow cytometry crossmatch and a donor-specific antibody titer < 1000 mean fluorescence intensity (MFI) were used to determine desensitization efficacy. A total of 36 patients underwent desensitization, and 27 (75%) were transplanted. After a follow-up of 58 ± 58 months (Min–Max: 0.13–169.5), five episodes of AR occurred: two antibody-mediated and three T-cell-mediated. No differences were found in baseline calculated panel-reactive antibodies (cPRA), class I or II MFI, number of antibodies, or Relative Intensity Scale (RIS) between AR and non-AR patients. Patients with antibody-mediated AR had higher cPRA (NS), MFI class I (p = 0.07) and class II (p = 0.006), and RIS (p = 0.01). The two patients with antibody-mediated AR and one patient with T-cell-mediated AR lost their grafts. In conclusion, the incidence of acute antibody-mediated rejection after desensitization was 7.4%, which occurred early post-transplantation in patients with high MFI and was associated with early graft loss.
Solar wind electric field driving of magnetospheric activity: Is it velocity or magnetic field?

The Lyon‐Fedder‐Mobarry global magnetohydrodynamic simulation code is used to examine a period of steady magnetospheric convection driven by a moderately southward IMF and a steady and quite low solar wind speed. Two other runs were performed to test the effects of increasing solar wind driving: one with 50% increase in the IMF magnitude and one with 50% increase in the solar wind speed. Larger IMF magnitude leads to nightside reconnection closer to the Earth but the steady state of the magnetotail is not changed. On the other hand, higher solar wind speed enhances Earthward mass and Poynting flux transport as well as their variability. The increase in the solar wind EY is the same for both runs, but the EY in the magnetosheath is larger in the run in which the speed is enhanced, which is associated with the higher magnetotail activity in that simulation.
12,000 years of landscape evolution in the southern White Mountains, New Hampshire, as recorded in Ossipee Lake sediments

Abstract Continuous records of sediment yield spanning from the late glacial through the Holocene to the present day provide an important opportunity to investigate landscape evolution over various timescales in response to a variety of natural and anthropogenic forcing mechanisms. This study investigates variations in sediment yield and landscape evolution in the 768 km2 watershed of Ossipee Lake, New Hampshire, USA. We pair subbottom sonar observations with analyses of lacustrine sediment cores to interpret a 12,000+ yr record of lake sedimentation in terms of changes in sediment yield and landscape evolution. Our results indicate high rates of sediment redistribution following deglaciation at ~14,500 to ~12,000 cal yr BP, followed by a period of gradually decreasing sediment yield until ~9000 cal yr BP, marking the termination of the most intense period of paraglacial landscape adjustment. From 9000 cal yr BP to 1850 CE, sediment yield is highly variable and reveals a slightly increasing trend that we attribute to a dominant hydroclimatic control on erosion driven by increasing effective precipitation in the region throughout the Holocene. Despite evidence for a highly dynamic landscape and an abundance of unconsolidated glacigenic surface deposits throughout the watershed, we interpret a modest erosional impact from anthropogenic land use.
Crack formation in two-dimensional annular networks

We used the random-fuse model to compute the topological features of localized cracks in an annular two-dimensional geometry. Depending on the type of disorder in the resistivity of the fuses, the results follow the observations encountered in the literature for square lattices with periodic boundary conditions or have a different behaviour explained by a small disorder in the resistivities. Finally, finite-size effects play an important role in this type of geometry.
Experimental and Analytical Study of High-Strength Concrete Containing Natural Zeolite and Additives

The study compares the durability of Natural Zeolite with Metakaolin, Silica Fume, and Fly Ash on high-strength concrete. 300 concrete specimens were tested for compressive strength before and after an acid attack, modulus of elasticity, water absorption, and rapid chloride permeability. 5%, 10%, and 15% of the cement were replaced with cementitious elements while maintaining the same quantity of Natural Zeolite. In this investigation, the water-cement ratio was maintained at 0.35. After 28 days, the specimens were tested for durability. Samples of all mixes were TG/DT and FTIR tested. The optimal percentages of cementitious materials that resulted to the maximum durability enhancements were reported as the study results. Experimental results showed that Natural Zeolite and Metakaolin strengthened the durability of concrete. All the data show that 5% Natural Zeolite with 10% Metakaolin performs well. Good R2values and appropriate independent variable coefficients suggested that the regression findings for high-strength concrete durability were accurate. The P values of all models were less than 0.005 and the F values were statistically significant and appropriate; therefore, the generated models predict concrete's strength with authenticity. Doi: 10.28991/CEJ-2022-08-10-019 Full Text: PDF
Social Determinants of Health and Impact on Screening, Prevalence, and Management of Diabetic Retinopathy in Adults: A Narrative Review

Diabetic retinal disease (DRD) is the leading cause of blindness among working-aged individuals with diabetes. In the United States, underserved and minority populations are disproportionately affected by diabetic retinopathy and other diabetes-related health outcomes. In this narrative review, we describe racial disparities in the prevalence and screening of diabetic retinopathy, as well as the wide-range of disparities associated with social determinants of health (SDOH), which include socioeconomic status, geography, health-care access, and education.
The Impact of Heavy Rainfall Variability on Fertilizer Application Rates: Evidence from Maize Farmers in China

Global warming increases the intensity and frequency of extreme weather events, which is harmful to agricultural production. Given that the overuse of fertilizer has been found to be a significant contributor to global warming, it is crucial to analyze the factors affecting farmers’ fertilizer use and find appropriate fertilizer reduction measures. Agriculture is inherently risky, but previous studies have ignored the risk factors related to heavy rainfall variability, including fertilizer losses and the possible yield risks, which may lead to income risk. Using the 1995–2018 National Rural Fixed Observation Point Survey Data, this study examines the impact of heavy rainfall variability on maize farmers’ fertilizer application rates, aiming to understand farmers’ fertilization behavior in response to weather shocks. The results show that heavy rainfall variability significantly increases farmers’ fertilizer application rates on maize. Furthermore, we find that heavy rainfall variability has greater effects on fertilizer use in hills and mountainous areas and areas with good irrigation conditions or high economic levels. When examining the potential channels underlying the estimated effects, we find that yield fluctuations are a channel through which heavy rainfall variability affects farmers’ fertilizer use on maize. The above results indicate that farmers view applying extra fertilizer as a risk reducing activity in response to rainfall shocks, which helps to prevent low yield and income. Strengthening agricultural infrastructure construction according to local conditions and promoting fertilizer reduction technologies and products to reduce yield risk caused by heavy rainfall can help alleviate the problem of high fertilizer application rates by Chinese farmers.
Effect of molecular conformation on the mesogenic properties of a partially fluorinated nematogenic compound investigated by X-ray diffraction and dielectric measurements

A bicyclohexyl trifluorophenyl compound has been studied in both the crystalline and the nematic phases by X-ray diffraction and dielectric methods. Difference in molecular geometry, conformation, packing, density and orientation of molecular dipole moments explains substantial increase of melting point and decrease of nematic range in the compound compared to structurally very closely related systems. The facts that the apparent length of molecules is about 1.35 times more than the most extended molecular length and the average value of the dielectric constant is about 6% less than the extrapolated isotropic phase values give conclusive evidence of existence of short-range antiparallel order in fluorinated compounds like cyanobiphenyls and isothiocyanates supporting our previous conclusion (Haldar S, Mandal PK, Prathap SJ, Guru Row TN, Haase W. X-ray studies of the crystalline and nematic phases of 4′-(3,4,5-trifluorophenyl)-4-propylbicyclohexyl. Liq Cryst. 2008;35:1307–1312). About 5 V dc bias is sufficient for switching the orientation of the molecules from homogeneous to homeotropic configuration. Dielectric anisotropy and splay elastic constant exhibit similar decreasing trend with temperature. Only one strong Debye-type dielectric absorption process, connected with reorientations of the molecules around the short axis, is observed. Dielectric spectra fitted to modified Cole-Cole function revealed that the relaxation frequency increases from 2.6 MHz to 4 MHz exhibiting Arrhenius-type behaviour. Activation energy of the thermally activated relaxation process is about 32.4 kJ/mole.
Hybrid finite‐volume finite‐difference scheme for the solution of Boussinesq equations

A hybrid scheme composed of finite‐volume and finite‐difference methods is introduced for the solution of the Boussinesq equations. While the finite‐volume method with a Riemann solver is applied to the conservative part of the equations, the higher‐order Boussinesq terms are discretized using the finite‐difference scheme. Fourth‐order accuracy in space for the finite‐volume solution is achieved using the MUSCL‐TVD scheme. Within this, four limiters have been tested, of which van‐Leer limiter is found to be the most suitable. The Adams–Basforth third‐order predictor and Adams–Moulton fourth‐order corrector methods are used to obtain fourth‐order accuracy in time. A recently introduced surface gradient technique is employed for the treatment of the bottom slope. A new model ‘HYWAVE’, based on this hybrid solution, has been applied to a number of wave propagation examples, most of which are taken from previous studies. Examples include sinusoidal waves and bi‐chromatic wave propagation in deep water, sinusoidal wave propagation in shallow water and sinusoidal wave propagation from deep to shallow water demonstrating the linear shoaling properties of the model. Finally, sinusoidal wave propagation over a bar is simulated. The results are in good agreement with the theoretical expectations and published experimental results. Copyright © 2005 John Wiley & Sons, Ltd.
Two‐loop Renormalization of Non‐smooth String Operators in Yang‐Mills Theory

The renormalization constants for string operators both with smooth and non-smooth non-self-intersecting open contour have been evaluated up to the order g4. 2-Loop-Renormierung nichtglatter String-Operatoren in der Yang-Mills-Theorie Es sind die Renormierungskonstanten fur String-Operatoren mit sowohl glatter als auch nichtglatter, einfacher, offener Kontur bis zur Ordnung g4 berechnet worden.
Analysis of corporate governance disclosure, environmental performance and company value (study on manufacture companies in indonesia stock exchange for 2015-2019)

Companies must try to find new ways to improve their products in the era of the industrial age 4.0. This is because the competition in industry 4.0 is getting more challenging, so management will try to keep the company's revenue growth. This study uses institutional ownership, the proportion of independent commissioners, the size of the audit committee, and environmental performance as independent variables and firm value as the dependent variable. The research method uses a quantitative approach with a research period of 2015-2019. The results show that the hypotheses for institutional ownership and the size of the audit committee are supported or accepted, while the hypotheses for the size of the audit committee and environmental performance are rejected. Obtaining the results of this study is expected to be the basis for evaluating and determining company policies. In addition, information regarding the research results provides a new perspective to the company that environmental performance is essential in maintaining the sustainability of living things and the company's operations around the community. In this study there are also limitations where the research period is limited to five years so that the results of hypothesis testing can only obtain two supported hypotheses. If the vulnerable research period is extended, the results of the hypothesis will provide more than two supported hypotheses. For further research, the authors provide suggestions in order to expand the research period in order to obtain wider research data and will provide good results compared to previous research.
Home Drug Delivery Service from the Perspective of Community Pharmacy Staff in Saudi Arabia

Background: In response to COVID-19, many big pharmacy chains in Saudi Arabia have started to provide home drug delivery services. This study aims to understand home drug delivery service from the perspective of community pharmacists in Saudi Arabia. Also, the study investigates the obstacles that may limit the use of home drug delivery service. Methods: A cross-sectional self-reported survey was distributed from February 2021 to May 2021. Descriptive analysis of sociodemographic characteristics was conducted and presented. Frequencies and percentages were calculated for all variables. Results: A total of 965 community pharmacists were surveyed. Most of the pharmacists, (73.5%) were young, aged 23 to 34 years old. The vast majority of the participants, (93.6%), said that the service will improve drug adherence. The lack of required knowledge and skills among pharmacists could be the main obstacle to implement home drug delivery service (34%). A shortage in the number of community pharmacists was the second main obstacle (24%). Conclusion: Home delivery services in the future may largely replace the tradition of going in person to the pharmacy. There are obstacles that may limit the full use of the service like shortage in number of pharmacists and the lack of required training.
Are Consumers Attentive to Local Energy Costs? Evidence from the Appliance Market

Abstract We estimate whether consumers respond to local energy costs when purchasing appliances. Using a dataset from an appliance retailer, we compare demand responsiveness to a measure of energy costs that varies with local energy prices versus purchase prices. We cannot reject that consumers respond to lifetime energy costs in the same way they respond to purchase prices under a wide range of assumptions. These findings run counter to the popular wisdom, which motivates energy standards, that energy costs are systematically undervalued due to various behavioral phenomena. They imply that electricity pricing that deviates from social marginal costs, due to failure to incorporate pollution externalities or due to other features in rate design, can have substantial distortionary effects on demand.
Understanding Employee Satisfaction in the Public Sector: Examining the Role of Communication Style, Individual Initiative, and Reward Systems

This research focuses on the main problem that employee job satisfaction in the departments, agencies, offices, and secretariats of Sumedang Regency, West Java, that deliver public services is less than optimal. This study thus investigates the reasons for employees’ lack of job satisfaction. It is based on the theoretical context of public administration science and applies the research method of quantitative analysis, while the population it studies are the structural officials who work in Sumedang. The research hypothesis is examined using the Partial Least Squares (PLS) approach to Structural Equation Modeling (SEM), supported by the Smart Partial Least Squares (SmartPLS) computer software program. The results of the study show that communication style, individual initiative, and the reward system together have a strong and significant influence on managerial support, which in turn affects employee job satisfaction in departments, agencies, offices, and secretariats in Sumedang. The study concludes that the concept of managerial support has a strong and definitive effect on employee job satisfaction. The findings suggest the need for further research on how communication style, individual initiative, reward systems, and managerial support can contribute to improving public services, especially from the perspective of public administration science. This study’s originality lies in how it highlights the need to adopt more flexible human resources management in the public sector, similar to that employed in the business sector.
Implementation of Educational Psychology in Improving the Quality of Learning at Elementary School 3 Klaten

Introduction: This “research is motivated by the problems of principals and teachers in applying educational psychology at Elementary School 3 Klaten to improve the quality of learning. In this case, many classroom teachers experience obstacles and difficulties implementing psychological education. Researchers observed and analyzed the implementation of educational psychology by Elementary School 3 Klaten teachers in improving the quality of learning. The objectives of this study include: knowing how teachers implement educational psychology, the obstacles experienced by teachers in implementing educational psychology, and reviewing teacher efforts in overcoming these obstacles to improve the quality of learning. Method: This study uses a descriptive qualitative approach. The research was conducted at Elementary School 3 Klaten for the academic year 2022/2023. This study analyses teachers implementing educational psychology and supervision carried out by school principals to improve the quality of learning. Result: Based on the analysis of observational data, documentation, and interviews, it shows that teachers at Elementary School 3 Klaten have implemented educational psychology in learning to improve the quality of learning with support and supervision carried out by the school principal. Conclusion: The implementation of educational psychology at Elementary School 3 Klaten is applied by teachers in various ways to improve the quality of learning, including using multiple methods in education, tools, and media, prioritizing interaction with students, providing guidance, motivation, attention, direction, and fair assessment.
The Effect of Process Approach Instruction upon Changing Pre-Service Elementary Teachers' Attitudes Toward Science.

The responsibility of and the challenge to every teacher of science were never greater. At the same time the pleasure, the excitement, and the importance of teaching science grow in direct proportion to increasing responsibilities and challenge. It is absolutely essential that pre-service and in-service teacher education programs be the best possible—a goal attainable only if all those interested in science, in teaching and in the public welfare offer to assist teachers and contribute their special talents to the improvement of teacher education. (1)
Complex angle part fabricated by vacuum bag only process with interleaved dry fiber and prepreg

This study used the vacuum bag-only process to fabricate angle composite parts on a complex-shape mold by employing interleaved unidirectional prepreg and dry fiber. The study focuses on the thickness variation along the angle part by analyzing the thickness distribution within the angle part by the statistic method. The corner thickness deviation (CTD) and angle deviation (AD) of the angle part were used to quantify the quality of the part by different process parameters and mold design. The results indicated that the CTD and AD were both linearly decreased with the increase of the part thickness. Besides, the part fabricated with the convex mold presented higher dimensional stability and uniformity as compared to that with the concave mold. In addition, we investigated the effect of caul plate applied at the corner regions, and the results showed that the lead caul plate could effectively improve the thickness change in the corner area in both the concave and convex mold. In order to fully understand the thickness variation of the part at the corner region, a semi-empirical model was proposed to forecast the corner thickness deviation of angle part. In this study, the prediction errors of the semi-empirical model for the parts by the concave and convex molds are 10% and 25%, respectively.
Prevalence of Antibiotics and Cr, Cd, Cu Metals Co-resistant Coliforms in Refuse Dumpsites and Air of Surrounding Buildings in a Nigerian Urban Setting

Prevalence of co-resistance to antibiotics and Cr6+, Cd2+, and Cu2+ among coliforms from dumpsites and surrounding buildings’ indoor and outdoor air was investigated in Warri town, in the Niger Delta region of Nigeria. A total of 1,465 coliforms were isolated with McConkey and Eosin Methylene Blue Agar, and 38.8% had multiple antibiotics resistance (MAR) index ≥ 0.3 based on nine antibiotics. The prevalence of coliform bacteria with a MAR index of ≥ 0.3 varied (20.0 - 69.2%) and was lower in indoor and outdoor air farther away from the dumpsites. All dumpsite isolates were resistant to Cr and Cd but not to Cu, while resistance varied (48.5 - 100%) among indoor and outdoor air isolates. Plasmid-encoded resistance was indicated when the mean MAR (0.48 ± 0.04 - 0.5 ± 0.04) and multiple heavy metal resistance (MHMR) indexes (0.66 ± 0.00) declined to 0.11 ± 0.01 - 0.36 ± 0.03 and 0.33 ± 0.00, respectively, after curing. The differences in MAR indexes of isolates from the four dumpsite locations and between indoor and outdoor air isolates were only significant (P < 0.05) after curing, unlike the MHMR index, where there was no significant difference before and after curing. The prevalence of metals and antibiotics co-resistance, which was based on the concomitant reduction in MAR and MHMR indexes after curing, was higher in isolates from dumpsites than in indoor and outdoor air (32.1 - 38.1 vs 0.0 - 16.8%). The role of plasmid-encoded genes in the co-resistance phenomenon was therefore indicated. Dumpsites as selective pressure spots for the emergence of resistance genes in bacteria should be of public health concern in countries characterised by indiscriminate dumping of wastes, as this can result in potential spread to houses via bioaerosols.
Upper estimates for hyperbolic metrics on subdomains: the case of equality

It is the purpose of this paper to supplement our previous work concerning upper estimates for hyperbolic metrics on subdomains. Specifically, our interest is in determining when equality holds in the relevant inequality to clarify the situation that has failed to be explicitly mentioned before. The method of proof again involves a standard technique based on the classical Schwarz–Pick lemma.