Miracle-dz/UniFAR-FTUs huggingface dataset:
Variability of Leser-Trélat Sign Secondary to Melanoma In Situ

Leser-Trélat sign (LTS) is characterized as an eruptive display of multiple seborrheic keratoses (SKs) in association with malignancy. This case highlights the variable presentation of LTS secondary to melanoma. To our knowledge, this LTS pattern is the first case where the sign manifests as a subtle pattern secondary to melanoma. This stands in contrast to the five documented cases in the literature of LTS-melanoma, which exhibited distinctive and eruptive patterns. A 64-year-old Caucasian female presented for a wellness examination. No personal history of skin cancer was noted. Patient displayed an onset proliferation of SKs with an irregular, sub-centimeter macular nevus over her right lateral mid back. A 6mm punch biopsy was significant for melanoma in situ, arising within a lentiginous compound dysplastic nevus, focally abutting one peripheral tissue edge. A re-excision with a minimum of 5mm margins was completed and the specimen was negative for residual in situ melanoma. Because of the rare occurrence of this delicate pattern at the site of the melanoma, this presentation adds to the knowledge surrounding this diagnosis. This case emphasizes the importance of maintaining vigilance regarding skin manifestations associated with disease and highlights the critical importance of observation and identification of subtle physical exam findings.
The Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Thoracoscopic Surgery for Lung Cancer: A Prospective, Randomized, Controlled Trial

Purpose This study was conducted to assess whether ciprofol vs propofol could affect the incidence of postoperative delirium (POD) in elderly patients with lung cancer after thoracoscopic surgery. Patients and Methods In this study, a total of 84 elderly patients undergoing thoracoscopic surgery for lung cancer were recruited and randomized into two groups to receive anesthesia with either ciprofol or propofol. The primary outcome was the incidence of POD within three days after surgery. Secondary outcomes included the Confusion Assessment Method (CAM) score, intraoperative indicators related to mean arterial pressure (MAP), and cerebral tissue oxygen saturation (SctO2). Moreover, MAP- and SctO2-related indicators associated with POD were analyzed. Results The incidence of POD was 7.1% and 16.7%, respectively, in the ciprofol group and the propofol group (risk ratio [RR], 0.37; 95% confidence interval [CI], 0.07 to 2.03; risk difference [RD], −9.6%; 95% CI, −23.3% to 4.1%; p = 0.178). Compared with those in the propofol group, patients in the ciprofol group had lower CAM scores three days after surgery (13 (12, 15) vs 15 (14, 17); 12 (11, 13) vs 14 (13, 16); 12 (11, 12) vs 13 (12, 14), p<0.05). Besides, patients in the ciprofol group exhibited higher mean and minimum MAP (88.63 ± 6.7 vs 85 ± 8.3; 69.81 ± 9.59 vs 64.9 ± 9.43, p<0.05) and SctO2 (77.26 ± 3.96 vs 75.3 ± 4.49, 71.69 ± 4.51 vs 68.77 ± 6.46, p<0.05) and percentage of time for blood pressure stabilization (0.6 ± 0.14 vs 0.45 ± 0.14, p<0.05) than those in the propofol group. Furthermore, MAP and SctO2-related indicators were validated to correlate with POD. Conclusion Anesthesia with ciprofol did not increase the incidence of POD compared with propofol. The results demonstrated that ciprofol could improve intraoperative MAP and SctO2 levels and diminish postoperative CAM scores.
Maxillary Sinus Augmentation with Xenogenic Collagen-Retained Heterologous Cortico-Cancellous Bone: A 3-Year Follow-Up Randomized Controlled Trial

Sinus augmentation procedures have become a valuable solution for patients with posterior maxillary edentulism. The objective of this study was to explore the efficacy and safety of porcine xenograft with collagen supplementation as a potential alternative to autologous bone grafts in lateral sinus augmentation over a three-year follow-up period. Twelve patients, each with bilateral posterior maxillary edentulism, were enrolled and randomly allocated to receive either a porcine xenograft or an autologous graft. Comprehensive assessments, including clinical and radiographic evaluations, were conducted at specific intervals, including implant stability, marginal bone loss, prosthetic and biological complications, and patient preferences. The results demonstrated no significant differences between the two graft materials in terms of implant survival, marginal bone loss, and patient preferences after three years of follow-up. Only one implant was affected by peri-implantitis, and prosthesis-related complications were present in one patient possibly due to bruxism. In conclusion, these findings suggest that a porcine xenograft with collagen supplementation may be a viable alternative to an autograft in lateral sinus augmentation procedures. The high implant survival rate, minimal complications, and patient satisfaction indicate the potential clinical relevance of this graft material and should be further investigated to confirm these promising results.
BLUEFIN TUNA MIGRATORY BEHAVIOR IN THE WESTERN AND CENTRAL MEDITERRANEAN SEA REVEALED BY ELECTRONIC TAGS

SUMMARY During 2008 and 2009 several tagging expeditions were carried out in the Mediterranean in order to determine Atlantic bluefin tuna trajectories and behavior. Tagging activities during 2008 were concentrated in the western Mediterranean. In 2009 the Adriatic Sea area, where tagging with pop-up tags on wild tuna had never taken place before, was also covered. Pop-up satellite archival tags and internal archival tags were used for adults and juveniles respectively. In total 4 pop-up and 21 archival tags were deployed in 2008, while 11 pop-up and 2 archival tags were used in 2009. Tagged bluefin tuna weights ranged from 12 to 200 kg. Data from all pop-up tags was successfully recovered and their retention rates ranged from 1 to 172 days. Additionally, a 2008 archival tag was recovered after 391 days at liberty. None of the tagged tunas left the Mediterranean Sea during the whole tracking period. Results suggest a residence pattern for large adults north of the Balearic Islands in late summer, and a link between the Gulf of Lions and the Tyrrhenian Sea, and between the Adriatic Sea and the Libyan coast. RESUME
Potential mechanisms for osteopathic manipulative treatment to alleviate migraine-like pain in female rats

Introduction Migraines are the leading cause of disability in the United States, and the use of non-pharmaceutical treatments like osteopathic manipulative treatment (OMT) has shown promise. Despite its potential, the lack of mechanistic understanding has hindered widespread adoption. This study aims to investigate the efficacy of OMT in treating acute migraines and unravel its underlying mechanisms of action. Methods Female rats were subjected to a “two-hit” approach to induce migraine-like pain. This involved bilateral injections of Complete Freund's Adjuvant (CFA) into the trapezius muscle (1st hit) followed by exposure to Umbellulone, a human migraine trigger, on Day 6 post-CFA (2nd hit). Soft tissue and articulatory techniques were applied to the cervical region for acute abortive or repeated prophylactic treatment. Cutaneous allodynia and trigeminal system activation were assessed through behavioral tests and immunohistochemical staining. Results Following Umbellulone inhalation, CFA-primed rats exhibited periorbital and hind paw allodynia. Immediate application of OMT after Umbellulone inhalation as an abortive treatment partially alleviated cutaneous allodynia. With OMT applied thrice as a prophylactic measure, complete suppression of tactile hypersensitivity was observed. Prophylactic OMT also prevented the increase of c-fos signals in the trigeminal nucleus caudalis and the elevation of calcitonin gene-related peptide expression in trigeminal ganglia induced by CFA and Umbellulone exposure at 2 h post-inhalation. Discussion These findings provide mechanistic insights into OMT's migraine-relief potential and underscore its viability as a non-pharmacological avenue for managing migraines.
Stabilization of Agricultural Soil Contaminated by Arsenic and Heavy Metals using Biochar derived from Buffalo Weed

Biochar, which has high alkalinity, has widely studied for amendment of soil that contaminated with heavy metals. The aim of this study is assessment of amendment for arsenic and heavy metals contaminated acidic agricultural soil using biochar that derived from buffalo weed ( A. trifida L. var. trifida ). Pot experiments were carried out including analysis of soil solution, contaminants fractionation, soil chemical properties and plant (lettuce) uptake rate. Arsenic and heavy metals concentrations in soil solution showed relatively low in biochar added experiments when compared to the control. In the heavy metals fractionation in soil showed decrease of exchangeable fraction and increase of carbonates fraction; however, arsenic fractionations showed constant. Soil chemical properties indicated that biochar could induce recovery of soil quality for plant growth in terms of soil alkalinity. However, phosphate concentration in biochar added soil decreased due to Ca-P precipitation by exchangeable calcium from biochar. Arsenic and heavy metals uptake rate of plant in the amended experiment decreased to 50% when compared to the control. Therefore biochar derived from buffalo weed can be used as amendment material for agricultural soil contaminated with arsenic and heavy metals. Precipitation of As-Ca and metal-carbonates are major mechanisms for soil amendment using char.
Genomic Analysis Points to Multiple Genetic Mechanisms for Non-Transformable Campylobacter jejuni ST-50

Campylobacter jejuni and Campylobacter coli are well known for their natural competence, i.e., their capacity for the uptake of naked DNA with subsequent transformation. This study identifies non-transformable C. jejuni and C. coli strains from domestic animals and employs genomic analysis to investigate the strain genotypes and their associated genetic mechanisms. The results reveal genetic associations leading to a non-transformable state, including functional DNase genes from bacteriophages and mutations within the cts-encoded DNA-uptake system, which impact the initial steps of the DNA uptake during natural transformation. Interestingly, all 38 tested C. jejuni ST-50 strains from the United States exhibit a high prevalence of non-transformability, and the strains harbor a variety of these genetic markers. This research emphasizes the role of these genetic markers in hindering the transfer of antimicrobial resistance (AMR) determinants, providing valuable insights into the genetic diversity of Campylobacter. As ST-50 is a major clone of C. jejuni globally, we additionally determined the prevalence of the genetic markers for non-transformability among C. jejuni ST-50 from different regions of the world, revealing distinct patterns of evolution and a strong selective pressure on the loss of competence in ST-50 strains, particularly in the agricultural environment in the United States. Our findings contribute to a comprehensive understanding of genetic exchange mechanisms within Campylobacter strains, and their implications for antimicrobial resistance dissemination and evolutionary pathways within specific lineages.
Digital interventions targeting excessive substance use and substance use disorders: a comprehensive and systematic scoping review and bibliometric analysis

Addictive substances are prevalent world-wide, and their use presents a substantial and persistent public health problem. A wide range of digital interventions to decrease use and negative consequences thereof have been explored, differing in approach, theoretical grounding, use of specific technologies, and more. The current study was designed to comprehensively map the recent (2015-2022) extant literature in a systematic manner, and to identify neglected and emerging knowledge gaps. Four major databases (Medline, Web of Science Core Collection, and PsychInfo) were searched using database-specific search strategies, combining terms related to clinical presentation (alcohol, tobacco or other drug use), technology and aim. After deduplication, the remaining n=13,917 unique studies published were manually screened in two stages, leaving a final n=3,056 studies, the abstracts of which were subjected to a tailored coding scheme. Findings revealed an accelerating rate of publications in this field, with randomized trials being the most common study type. Several meta-analyses on the topic have now been published, revealing promising and robust effects. Digital interventions are being offered on numerous levels, from targeted prevention to specialized clinics. Detailed coding was at times made difficult by inconsistent use of specific terms, which has important implications for future meta-analyses. Moreover, we identify several gaps in the extant literature – few health economic assessments, unclear descriptions of interventions, weak meta-analytic support for some type of interventions, and limited research on many target groups, settings and new interventions like video calls, chatbots and artificial intelligence – that we argue are important to address in future research.
Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance

We have reviewed the development and current status of therapies based on exposure to non-ionizing radiation (with a photon energy less than 10 eV) aimed at suppressing the venous neointimal hyperplasia, and consequentially at avoiding stenosis in arteriovenous grafts. Due to the drawbacks associated with the medical use of ionizing radiation, prominently the radiation-induced cardiovascular disease, the availability of procedures using non-ionizing radiation is becoming a noteworthy objective for the current research. Further, the focus of the review was the use of such procedures for improving the vascular access function and assuring the clinical success of arteriovenous fistulae in hemodialysis patients. Following a brief discussion of the physical principles underlying radiotherapy, the current methods based on non-ionizing radiation, either in use or under development, were described in detail. There are currently five such techniques, including photodynamic therapy (PDT), far-infrared therapy, photochemical tissue passivation (PTP), Alucent vascular scaffolding, and adventitial photocrosslinking. The last three are contingent on the mechanical stiffening achievable by the exogenous photochemical crosslinking of tissular collagen, a process that leads to the decrease of venous compliance. As there are conflicting opinions on the role of compliance mismatch between arterial and venous conduits in a graft, this aspect was also considered in our review.
Research on the Effect of Vibrational Micro-Displacement of an Astronomical Camera on Detector Imaging

Scientific-grade cameras are frequently employed in industries such as spectral imaging technology, aircraft, medical detection, and astronomy, and are characterized by high precision, high quality, fast speed, and high sensitivity. Especially in the field of astronomy, obtaining information about faint light often requires long exposure with high-resolution cameras, which means that any external factors can cause the camera to become unstable and result in increased errors in the detection results. This paper aims to investigate the effect of displacement introduced by various vibration factors on the imaging of an astronomical camera during long exposure. The sources of vibration are divided into external vibration and internal vibration. External vibration mainly includes environmental vibration and resonance effects, while internal vibration mainly refers to the vibration caused by the force generated by the refrigeration module inside the camera during the working process of the camera. The cooling module is divided into water-cooled and air-cooled modes. Through the displacement and vibration experiments conducted on the camera, it is proven that the air-cooled mode will cause the camera to produce greater displacement changes relative to the water-cooled mode, leading to blurring of the imaging results and lowering the accuracy of astronomical detection. This paper compares the effects of displacement produced by two methods, fan cooling and water-circulation cooling, and proposes improvements to minimize the displacement variations in the camera and improve the imaging quality. This study provides a reference basis for the design of astronomical detection instruments and for determining the vibration source of cameras, which helps to promote the further development of astronomical detection.
Unravelling the Link between Social Media Usage and Academic Achievement among ESL Learners: A Quantitative Analysis

On account of the widespread utilization of social media worldwide, much research has been done to ascertain how it affects the Learning achievement of students. Therefore, the aim of this study was to explore the relationship between social media use and academic performance in English as a second language (ESL) students. 412 secondary school students from Karachi participated in the study,which used quantitative research techniques. The study's conclusions showed that students used social media platforms to a respectable extent. Additionally, it was found that ESL students' use of social media considerably improved their ESL learning outcomes. By identifying the influence of social media use, educators and policymakers may create plans to maximize its potential for raising academic engagement and performance among ESL students. It may also come from further research in this area, which will ultimately benefit ESL students and their educational experiences.
STRONG MOTION RECORDS AT KOBE PORT ISLAND

ABSTRACT Vertical array records obtained at Kobe Port Island during the Hyogo-ken nanbu earthquake were analyzed. Acceleration records at four different depths were obtained. The peak horizontal acceleration was minimum at the ground surface and increased with depth, whereas, the peak vertical acceleration, the peak horizontal velocity, and displacement all decrease with depth. The de-amplification of the horizontal acceleration was due to non-linear effect of soils.The amplification of the vertical acceleration was caused by small P-wave velocity in the unsaturated fill layer which resulted in a large velocity contrast at the boundary between the unsaturated and saturated layer. Using ground response analysis, the equivalent linear soil parameters were obtained for 50% of the rigidities of the shear wave velocity with PS-logging. A method of synthesis of strong ground motion by summation’s aftershock records was applied to simulate the main shock at the ground surface and at a depth at GL-83 m. Synthesized strong motion at GL-83 m compared relatively well to the recorded one. Strong ground motion synthesized at the ground surface indicated twice larger peak acceleration than the observed. The smaller amplitude observed at the ground surface was due to the non-linear effect of soils.
National Development in the Use of Inhaled Corticosteroid Treatment in Chronic Obstructive Pulmonary Disease: Repeated Cross-Sectional Studies from 1998 to 2018

Recommendations for the treatment of chronic obstructive pulmonary disease (COPD) have shifted towards a more restrictive use of inhaled corticosteroids (ICS). We aimed to identify the nationwide development over time in the use of ICS treatment in COPD. We conducted a register-based repeated cross-sectional study using Danish nationwide registers. On a yearly basis from 1998 to 2018, we included all patients in Denmark ≥ 40 years of age with an ICD-10 diagnosis of COPD (J44). Accumulated ICS use was calculated for each year based on redeemed prescriptions. Patients were divided into the following groups: No ICS, low-dose ICS, medium-dose ICS, or high-dose ICS. From 1998 to 2018, the yearly proportion of patients without ICS treatment increased (from 50.6% to 57.6%), the proportion of patients on low-dose ICS treatment increased (from 11.3% to 14.9%), and the proportion of patients on high-dose ICS treatment decreased (from 17.0% to 9.4%). We demonstrated a national reduction in the use of ICS treatment in COPD from 1998 to 2018, with an increase in the proportion of patients without ICS and on low-dose ICS treatment and a decrease in the proportion of patients on high-dose ICS treatment.
Subsurface-intensified oceanic vortices : impact on the sea-surface and mutual interactions

Subsurface-intensified vortices are ubiquitous in the world ocean. They are often generated by water mass exchanges between semi-closed evaporation basins (e.g.: Mediterranean Sea, Red Sea, Persian Gulf) and the open ocean or during deep convection processes. These vortices can maintain a coherent geometry during inter-annual timescales and, due to their migration, they are able to carry large amounts of heat, salt and nutrients. Hence, the class of subsurface-intensified vortices participates to the redistribution of oceanic tracers along the three dimensions and at global scale, justifying the interest in determining their positions and mean pathways in the ocean. In general, vortices are able to locally modify the ocean surface generating anomalies that allow one to track them via satellite sensors. Our study, based on the use of analytical and numerical models, deals with the characterization of the sea-surface anomalies generated by subsurface-intensified vortices in terms of Sea-Surface Height (the elevation of the oceanic free-surface, SSH), Sea-Surface Temperature (SST) and Sea-Surface Salinity (SSS). In a first analysis, we have studied the SSH anomalies generated by subsurface vortices in an idealized context. Their properties have been related to the three-dimensional structure of the vortex, allowing us to state that only subsurface mesoscale vortices can be detected by the presentday altimetric observations. Furthermore, using a realistic model, we have studied the sea-surface expression of Mediterranean Water Eddies (MEDDIES) in SSH, SST and SSS. The study has evidenced the main differences between the Meddies-induced SSH anomalies and their thermohaline surface anomalies (i.e., SST and SSS): the first exhibit horizontal structures and intensities that can always be related to the Meddy structural changes at depth, while the second are mostly driven by the local surface dynamics.These studies show that the automatic tracking of subsurface-intensified vortices is mostly possible in an altimetric perspective, further confirming the importance of future high-resolution altimetric satellite missions, like SWOT.
Keeping the promise: a critique of the current state of microdosing research

Introduction The practice of taking small, sub-hallucinogenic doses of psychedelics, known as microdosing, has exploded in popularity over the last decade. Users claim benefits ranging from improved mood and enhanced creativity to an increased sense of meaning and connectedness in life. While research on microdosing is still lagging behind the shift in public opinion, several papers have been published in the last five years which attempted to assess the effects of microdosing. Methods This review paper aimed to critically analyze the research practices used in the recent wave of microdosing research: We reviewed 15 papers published before the closing date of this review in March 2022. Results Our review concludes that it is premature to draw any conclusions about the efficacy or safety of microdosing since the research quality cannot be considered confirmatory. Discussion We propose some potential causes for the current state of the literature and some suggestions for how these causes may be ameliorated.