Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental Sepsis Association with Nitric Oxide Synthase-3 in Implications following Its Physical Nitration and Pathophysiological Site-Specific Carboxypeptidase B1 Tyrosine

LPS-induced sepsis results in oxidative modiﬁcation and inactivation of carboxypeptidase B1 (CPB1). In this study, immunoprecipitated CPB1 was probed for tyrosine nitration using monoclonal nitrotyrosine-speciﬁc Abs in a murine model of LPS-induced sepsis. Tyrosine nitration of CPB1 was signiﬁcantly reduced in the presence of NO synthase (NOS) inhibitors and the xanthine oxidase (XO) inhibitor allopurinol and in NOS-3 knockout (KO) mice. CPB1 tyrosine nitration and loss of activity by the concerted action of NOS-3 and XO were also conﬁrmed in vitro using both the NO donor 3-morpholinosydnonimine and peroxynitrite. Liquid chromatography/tandem mass spectrometry data indicated ﬁve sites of tyrosine nitration in vitro including Tyr 248 , the tyrosine at the catalytic site. The site- and protein-speciﬁc nitration of CPB1 and the possible high nitration yield to inactivate it were elucidated by confocal microscopy. The studies indicated that CPB1 colocalized with NOS-3 in the cytosol of sinus-lining cells in the red pulp of the spleen. Further analysis of CPB1-immunoprecipitated samples indicated immunoreactivity to a monoclonal NOS-3 Ab, suggesting protein complex formation with CPB1. XO and NOS inhibitors and NOS-3 KO mice injected with LPS had decreased levels of C5a in spleens of septic mice, indicating peroxynitrite as a possible cause for CPB1 functional alteration. Thus, CPB1 colocalization, coupling, and proximity to NOS-3 in the sinus-lining cells of spleen red pulp could explain the site-speciﬁc tyrosine nitration and inactivation of CPB1. These results open up new avenues for the investigation of several enzymes involved in inﬂammation and their site-speciﬁc oxidative modiﬁcations by protein-protein interactions as well as their role in sepsis. The Journal of Immunology, 2009, 183: 4055–4066. used for the acquisition of the electrospray ionization mass spectra and tandem mass spectra. All experiments were performed in the positive ion mode. Lyophilized HPLC fractions of nitrated peptides were resuspended in a minimal volume ( (cid:5) 50 (cid:1) l) of 50:50 water:acetonitrile containing 0.1% formic acid and infused into the mass spectrometer at (cid:5) 300 nl/min using a pressure injection vessel (18). The was (cid:5) 3,200 volts and the collision energy was 10 eV for the mass spectrometry analyses. Collision-induced dissociation experiments used argon with collision energy between 30 and 50 electron volts. Data analysis was accomplished with a MassLynx data system and MaxEnt deconvolution software supplied by the manufacturer.
Hajimirzaee, Saeed and Chansai, Sarayute and Hardacre, Christopher and Banks, Craig E and Doyle, Aidan M (2019) Effects of surfactant on morphol-

Hydroxyapatite (HAP) was synthesised in the presence of surfactants and tested as a catalyst in CO oxidation. XRD confirmed that the characteristic HAP crystal phase was practically unaffected by the addition of surfactant. The surfactant altered both the Ca/P ratio and particle size of HAP. Catalyst tests showed that the activity of HAP increased for preparations using TWEEN, PEG and PVA. The temperature for 50% conversion, T50, values decreased from 340 °C for unmodified HAP, to 320 °C for TWEEN and to 315 °C for both PEG and PVA. This enhanced activity is rationalised by the higher BET surface areas and acid site densities in the surfactant-modified preparations: these increased from 52 m g for HAP to 69, 76 and 68 m g, and from 101 μmoles g for HAP to 110, 170 and 126 μmoles g for TWEEN, PEG and PVA, respectively. These findings demonstrate that HAP i.e. without the addition of precious metals to either the surface or framework, is an active CO catalyst and that the straightforward inclusion of surfactant during preparation can optimise the catalytic performance.
Internal control of the Schrödinger equation

In this paper, we intend to present some already known results about the internal controllability of the linear and nonlinear Schrödinger equation. After presenting the basic properties of the equation, we give a self contained proof of the controllability in dimension 1 using some propagation results. We then discuss how to obtain some similar results on a compact manifold where the zone of control satisfies the Geometric Control Condition. We also discuss some known results and open questions when this condition is not satisfied. Then, we present the links between the controllability and some resolvent estimates. Finally, we discuss the new difficulties when we consider the Nonlinear Schrödinger equation.
Solutions of the benchmark problems by the dispersion-relation-preserving scheme

The 7-point stencil Dispersion-Relation-Preserving scheme of Tam and Webb is used to solve all the six categories of the CAA benchmark problems. The purpose is to show that the scheme is capable of solving linear, as well as nonlinear aeroacoustics problems accurately. Nonlinearities, inevitably, lead to the generation of spurious short wave length numerical waves. Often, these spurious waves would overwhelm the entire numerical solution. In this work, the spurious waves are removed by the addition of artificial selective damping terms to the discretized equations. Category 3 problems are for testing radiation and outflow boundary conditions. In solving these problems, the radiation and outflow boundary conditions of Tam and Webb are used. These conditions are derived from the asymptotic solutions of the linearized Euler equations. Category 4 problems involved solid walls. Here, the wall boundary conditions for high-order schemes of Tam and Dong are employed. These conditions require the use of one ghost value per boundary point per physical boundary condition. In the second problem of this category, the governing equations, when written in cylindrical coordinates, are singular along the axis of the radial coordinate. The proper boundary conditions at the axis are derived by applying the limiting process of r approaches 0 to the governing equations. The Category 5 problem deals with the numerical noise issue. In the present approach, the time-independent mean flow solution is computed first. Once the residual drops to the machine noise level, the incident sound wave is turned on gradually. The solution is marched in time until a time-periodic state is reached. No exact solution is known for the Category 6 problem. Because of this, the problem is formulated in two totally different ways, first as a scattering problem then as a direct simulation problem. There is good agreement between the two numerical solutions. This offers confidence in the computed results. Both formulations are solved as initial value problems. As such, no Kutta condition is required at the trailing edge of the airfoil.
Minimal residual disease using liquid biopsies in hematologi- cal malignancies

The study of cell-free DNA (cfDNA) and other peripheral blood components (known as “liquid biopsies”) is promising and has been investigated especially in solid tumors. Nevertheless, it is increasingly showing greater utility in the diagnosis, prognosis, and response to treatment of hematological malignancies; in the future, it could prevent invasive techniques, such as bone marrow (BM) biopsy. Most of the studies about this topic have been focused on B cell lymphoid malignancies; some of them have shown that cfDNA can be used as a novel way for diagnosis and minimal residual monitoring in B cell lymphomas, using techniques such as next-generation sequencing (NGS). In myelodysplastic syndromes, multiple myeloma, or chronic lymphocytic leukemia, liquid biopsies may allow for an interesting genomic representation of the tumor clones affecting different lesions (spatial heterogeneity). In acute leukemias, it can be helpful in the monitoring of early treatment response and the prediction of treatment failure. In chronic lymphocytic leukemia, the evaluation of cfDNA permits the definition of clonal evolution and drug resistance in real time. However, there are limitations such as the difficulty in obtaining sufficient circulating tumor DNA for achieving a high sensitivity to assess minimal residual disease or the lack of standardization of the method and clinical studies to confirm its prognostic impact. This review focuses on clinical applications of cfDNA on minimal residual disease in hematological malignancies.
Case Burkitt’s Lymphoma of the Stomach: A Case Report and Review of the Literature

Sporadic Burkitt’s Lymphoma (BL) is a subtype of Non-Hodgkins Lymphoma (NHL). In contrast to other types of NHL, sporadic Burkitt’s lymphoma usually affects the ileocaecal area of small bowel. We report a case of sporadic BL affecting the stomach, which represents an under-reported manifestation of the disease. This is followed by a review of the literature on gastric Burkitt’s lymphoma.
OPTH_A_262060 2843..2854

1Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Anesthesiology, Pain and Critical Care, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Ophthalmology, Southern California Permanent Medical Group, Baldwin Park, CA, USA; 4Eye Monitoring Center, Kaiser Permanent Southern California, Baldwin Park, CA, USA; 5Department of Research and Evaluation, Southern California Permanente Medical Group, Pasadena, CA Objective: This paper reviews ocular pain with the main focus on ocular surface discomfort and dry eye pain. Anatomy, physiology, epidemiology, assessment, and treatment are discussed in this paper. Methods: A PubMed search was conducted for studies published from 2000 to 2019 on the anatomy, pathophysiology, epidemiology, assessment, and treatment of ocular pain. Reviews, meta-analyses, and randomized clinical trials were included. Inclusion criteria focused on ocular surface discomfort, dry eye pain and neuropathic pain. Results: A total of 112 articles were found through searches, 45 of which were selected and studied in this review. Discussion: Pain in general can be acute or chronic. Acute pain is usually a physiologic response to a serious damage to the tissues and alleviates with pain relief treatments. Chronic pain is defined as the persistence of pain for more than three months. From another point of view, pain has been classified into either nociceptive or neuropathic. Nociceptive pain is a physiologic response to a noxious stimulus. Both central and peripheral nervous systems can be involved in the development of a neuropathic pain, which is characterized by positive or negative sensory signs, a pain perceived disproportionate to a noxious stimulus, and/or not responsive to analgesics. Chronic pain usually has a neuropathic component. Ocular surface pain is a well-known complaint after any corneal surgery. This is mainly due to abnormal regeneration of damaged corneal nerve endings and abnormal connections with adjacent nerve endings which produce spontaneous activity. Tear hyperosmolarity and the resultant ocular surface inflammation can also trigger voluntary activity of corneal nerve endings. Referral pain to the first and second division of the trigeminal nerve has been reported. Interference with vision and even sleep, which is out of proportion to the examination are among patients’ complaints. All of these elements proposed the new concept of ocular neuropathic pain syndrome. The first step in conventional evaluation of ocular discomfort is search for tear insufficiency. Pathologies of lid and blinking as well as conjunctival irregularities should be addressed. Anti-inflammatory agents and, in resistant cases, systemic neuromodulators are shown to be helpful. Education on behavioral changes and reassurance are essential steps. Considering the neuropathic origin for the ocular pain, treatment modalities used for such pain in other parts of the body can be considered for this syndrome.
Comparing the e cacy and safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for sedation in colonoscopy patients: A double- blinded randomized clinical trial

Reza Aminnejad Qom University of Medical Sciences and Health Services Ahmad Hormati (  hormatia@yahoo.com ) Qom University of Medical Sciences and Health Services https://orcid.org/0000-0002-1322-1318 Hamed Sha ee Qom University of Medical Sciences and Health Services Faezeh Alemi Qom University of Medical Sciences and Health Services Maryam Hormati Qom University of Medical Sciences and Health Services Mohammad Saeidi Qom University of Medical Sciences and Health Services Sajjad Ahmadpour Qom University of Medical Sciences and Health Services Seyed Mahdi Sabouri Qom University of Medical Sciences and Health Services Mohammad Aghaali Qom University of Medical Sciences and Health Services
Planck intermediate results. LV. The Planck Multi-frequency Catalogue of Non-thermal Sources

This paper presents the Planck Multi-frequency Catalogue of Non-thermal (i.e., synchrotron-dominated) Sources (PMNT) observed between 30 and 857 GHz by ESA’s Planck mission. This catalogue has been constructed by selecting objects detected in the full mission all-sky temperature maps at 30 and 143 GHz, with a signal-to-noise ratio (S/N) > 3 in at least one of the two channels after ﬁltering with a particular Mexican-hat wavelet. As a result, 29 400 source candidates have been selected. Then, a multi-frequency analysis has been performed using the “Matrix Filters” methodology at the position of these objects, and ﬂux densities and errors have been calculated for all of them in the nine Planck channels. This catalogue has been built using a diﬀerent methodology than the one adopted for the Planck Catalogue of Compact Sources (PCCS) and the Second Planck Catalogue of Compact Sources (PCCS2), although the initial detection is done with the same pipeline that was used to produce them. The present catalogue is the ﬁrst unbiased, full-sky catalogue of synchrotron-dominated sources published at millimetre and submillimetre wavelengths and constitutes a powerful database for statistical studies of non-thermal extragalactic sources, whose emission is dominated by the central active galactic nucleus. Together with the full multi-frequency catalogue, we also deﬁne the so-called Bright Planck Multi-frequency Catalogue of Non-thermal Sources (B-PMNT), where only those objects with a S / N > 4 at both 30 and 143 GHz have been selected. In this catalogue 1146 compact sources are detected outside the adopted Planck GAL070 mask; thus, these sources constitute a highly reliable sample of extragalactic radio sources. We also ﬂag the so-called high-signiﬁcance subsample (HS-PMNT), a subset of 151 sources that are detected with S / N > 4 in all nine Planck channels, out of which 75 are found outside the Planck mask adopted here. The remaining 76 sources inside the Galactic mask are very likely Galactic objects.
NSS_A_277647 1191..1200

1Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Marconi Institute for Creativity (MIC), Bologna, Italy; 3Department of Electrical, Electronic, and Information Engineering “Guglielmo Marconi”, University of Bologna, Bologna, Italy; 4IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 5Université de Paris and Univ Gustave Eiffel, LaPEA, Paris, France; 6Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy Purpose: A higher creative potential has been reported in narcoleptic patients and linked to lucid dreaming. The aim of the present study was to explore the role of narcolepsy symptoms (presence and severity) in predicting creativity. Patients and Methods: Sixty-six consecutive type 1 narcolepsy patients (mean age 38.62 ± 17.05, 31 females) took part in this study. Creative achievement in different life domains and creative beliefs were assessed by a self-reported questionnaire and a scale measuring the creative self, respectively; creative performance was measured through a divergent thinking test (generation of alternative original solutions to an open problem). Results: We found a key effect of hypnagogic hallucinations in modulating creative behaviour. We therefore tested at first whether hypnagogic hallucinations could interact with specific mental states associated with creativity and in particular mind wandering, a factor associated with both creative performance and achievement. Secondly, we verified if hypnagogic hallucinations could influence the definition of creative identity in type 1 narcolepsy patients, which in turn could predict their creative achievement and creative performance. Results showed that spontaneous mind wandering influenced creative achievement through a moderation effect of sleep paralysis and hypnagogic hallucinations. Moreover, sleep paralysis and hypnagogic hallucinations indirectly influenced, through creative identity, both creative achievement and performance (fluency score). Conclusion: Our results highlight the role of hypnagogic hallucinations in triggering the process of mind wandering which leads to greater creative success. In addition, this symptom affects creative identity in narcolepsy, leading in turn to higher creative success and creative potential of narcoleptic patients.
ADDIS ABABA UNIVERSITY COLLEGE OF HEALTH SCIENCES SCHOOL OF ALLIED HEALTH SCIENCE DEPARTMENT OF NURSING AND MIDWIFERY KNOWLEDGE AND ATTITUDE OF NURSES TOWARDS PALLIATIVE CARE IN GOVERNMENT HEALTH HOSPITALS OF ADDIS ABABA,

VII UNIT ONE: INTRODUCTION. 1 1.1. Background . 1 1.2. Statement of the Problem . 3 1.3. Research questions . 5 1.4. Significance of the Study . 6 UNIT TWO: LITERATURE REVIEW . 7 2.1. Nurses’ knowledge towards Palliative care . 7 2.2. Nurses’ attitude towards Palliative care . 11 2.3. Associated factors of nurses’ palliative care knowledge and attitude . 14 2.4. Conceptual framework . 18 UNIT THREE: OBJECTIVES. 19 3.1. General objective . 19 3.2. Specific objectives . 19 UNIT FOUR: METHODS AND MATERIALS . 20 4.1. Study Area: . 20 4.2. Study design . 20 4.3. Study period . 20 4.4. Populations . 20 4.4.1. Source population . 20 4.4.2. Study population . 21 4.4.3. Inclusion and exclusion criteria . 21 4.5. Sample size determination . 21 4.6. Sampling technique and Sampling procedure . 22 4.7. Proportional allocation . 23 III 4.8. Variables of the Study . 25 4.8. 1. Dependent Variables . 25 4.8. 2. Independent Variables . 25 4.9. Operational definition . 25 4.10. Methods of data collection . 26 4.10. 1. Data collection tool . 26 4.10. 2. Data collection procedure . 26 4.10. 3. Data quality control . 27 4.11. Data analysis . 27 4.12. Ethical consideration . 27 4.13. Dissemination and Utilization of Result . 28 UNIT FIVE: RESULTS . 29 5.1. Socio-demographic characteristics of the study participants . 29 5.2. Nurses’ Knowledge towards palliative Care . 32 5.3. Nurses' attitude towards palliative care . 34 5.4. Association between selected variables and nurses knowledge towards palliative care . 37 5.5. Association between selected variables and nurses attitude towards palliative care . 39 UNIT SIX: DISCUSSION . 40 Strength and Limitations of the study . 44 UNIT SEVEN: CONCLUSION AND RECOMMENDATIONS . 45 7.1. Conclusion . 45 7.2. Recommendations . 45 References . 46 ANNEX . i ANNEX I Information sheet and consent form . i ANNEX II Questionnaire . iii
Spectroscopic diversity of Type Ia supernovae

A comparison of the ratio of the depths of two absorption features in the spectra of Type Ia supernovae (SNe Ia) near the time of maximum brightness with the blueshift of the deep red Si ii absorption feature 10 days after maximum shows that the spectroscopic diversity of SNe Ia is multidimensional. There is a substantial range of blueshifts at a given value of the depth ratio. We also find that the spectra of a sample of SNe Ia obtained a week before maximum brightness can be arranged in a “blueshift sequence” that mimics the time evolution of the pre–maximum-light spectra of an individual SN Ia, the well-observed SN 1994D. Within the context of current SN Ia explosion models, we suggest that some of the SNe Ia in our sample were delayed detonations while others were plain deflagrations. Subject headings: hydrodynamics — radiative transfer — supernovae: general — supernovae: individual (SN 1984A, SN 1992A, SN 1994D)
ENHANCING LEARNING OUTCOMES BY INTRODUCING BIM IN CIVIL ENGINEERING STUDIES – EXPERIENCES FROM A UNIVERSITY COLLEGE IN NORWAY

It is a challenge to introduce building information modeling (BIM), as demanded from the industry, in an already packed curriculum for higher engineering education. There is therefore a need for alternative ways to include BIM in the curriculum, while at the same time strengthening – rather than supplanting – the traditional engineering subjects. The purpose of this study is increased understanding of how BIM can be integrated as part of an engineering curriculum in an efficient way. The study is based on an evaluation of the ‘Introduction to Building Professions’ course given to all civil engineering students in their first semester of the bachelor’s degree programme at Oslo and Akershus University College of Applied Sciences in Norway. Autodesk Revit was used as BIM-based software in the designing of a two-family timber dwelling, a compulsory group project in the course. Data for this paper are collected from multiple sources: a net-based questionnaire, course evaluations, interviews with students and teachers, and assessment of students’ project work. Selected factors in Active Learning theories are used as a theoretical lens for analyzing the data in a systematic way. BIM enabled a design and ‘virtual construction’ process where students held professional roles in a design team, and contributed with their expertise toward a holistic solution. The students reported that the hands-on modeling with BIMbased software led to increased understanding of design parameters, load distribution, and construction detailing, as well as information requirements for collaboration within a design team. We conclude that BIM in higher engineering education can support understanding of professional content, which is the primary learning outcome. Software proficiency is seen as a necessary yet subordinate skill in higher education and should not be graded as a separate task. Use of BIM-based software should, however, be integrated to enhance problem understanding and relevant information processing. This integrated approach can lead to a more widespread implementation of BIM to support active learning in higher education.