Miracle-dz/UniFAR-FTUs huggingface dataset:
A Spectroscopic Survey of Redshift 1.4 ≲ z ≲ 3.0 Galaxies in the GOODS-North Field: Survey Description, Catalogs, and Properties

We present the results of a spectroscopic survey with LRIS-B on Keck of more than 280 star-forming galaxies and AGNs at redshifts 1.4 ≲ z ≲ 3.0 in the GOODS-N field. Candidates are selected by their UnGℛ colors using the ``BM/BX'' criteria to target redshift 1.4 ≲ z ≲ 2.5 galaxies and the LBG criteria to target redshift z ~ 3 galaxies; combined these samples account for ~25%-30% of the ℛ and Ks band counts to ℛ = 25.5 and Ks(AB) = 24.4, respectively. The 212 BM/BX galaxies and 74 LBGs constitute the largest spectroscopic sample of galaxies at z > 1.4 in GOODS-N. Extensive multiwavelength data allow us to investigate the stellar populations, stellar masses, bolometric luminosities (Lbol), and extinction of z ~ 2 galaxies. Deep Chandra and Spitzer data indicate that the sample includes galaxies with a wide range in Lbol (≃1010 to >1012 L☉) and 4 orders of magnitude in dust obscuration (Lbol/LUV). The sample includes galaxies with a large dynamic range in evolutionary state, from very young galaxies (ages ≃50 Myr) with small stellar masses (M* ≃ 109 M☉) to evolved galaxies with stellar masses comparable to the most massive galaxies at these redshifts (M* > 1011 M☉). Spitzer data indicate that the optical sample includes some fraction of the obscured AGN population at high redshifts: at least 3 of 11 AGNs in the z > 1.4 sample are undetected in the deep X-ray data but exhibit power-law SEDs longward of ~2 μm (rest frame) indicative of obscured AGNs. The results of our survey indicate that rest-frame UV selection and spectroscopy presently constitute the most timewise efficient method of culling large samples of high-redshift galaxies with a wide range in intrinsic properties, and the data presented here will add significantly to the multiwavelength legacy of GOODS.
Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis: Results of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

Significance Statement The syndrome of inappropriate antidiuresis (SIAD) is a major cause of hypotonic hyponatremia. Despite its prevalence, treatment options are sparse, and data on their effect on hyponatremia-associated morbidity such as neurocognitive impairment are largely lacking. New treatment options are needed. The sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin promotes osmotic diuresis via urinary glucose excretion and could be used as a treatment for chronic SIAD. This randomized, double-blind, placebo-controlled, crossover trial with 14 participants revealed that empagliflozin is well tolerated and effective compared with placebo. In addition, treatment with empagliflozin possibly led to an improvement in neurocognitive function. The results set the stage for further studies evaluating empagliflozin as a treatment option in patients with SIAD-induced hyponatremia. Background The syndrome of inappropriate antidiuresis (SIAD) is characterized by a reduction of free water excretion with consecutive hypotonic hyponatremia and is therefore challenging to treat. The sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin promotes osmotic diuresis via urinary glucose excretion, likely leading to increased electrolyte free water clearance. Methods In this randomized, double-blind, placebo-controlled, crossover trial, we compared 4-week treatment with empagliflozin 25 mg/d to placebo in outpatients with chronic SIAD-induced hyponatremia. At baseline and after both treatment cycles, patients underwent different assessments including neurocognitive testing (Montreal Cognitive Assessment [MoCA]). The primary end point was the difference in serum sodium levels between treatments. Results Fourteen patients, 50% female, with a median age of 72 years (interquartile range [IQR], 65–77), completed the trial. Median serum sodium level at baseline was 131 mmol/L (IQR, 130–132). After treatment with empagliflozin, median serum sodium level rose to 134 mmol/L (IQR, 132–136), whereas no increase was seen with placebo (130 mmol/L; IQR, 128–132), corresponding to a serum sodium increase of 4.1 mmol/L (95% confidence interval [CI], 1.7 to 6.5; P=0.004). Exploratory analyses showed that treatment with empagliflozin led to improved neurocognitive function with an increase of 1.16 (95% CI, 0.05 to 2.26) in the MoCA score. Treatment was well tolerated; no serious adverse events were reported. Conclusion The SGLT2 inhibitor empagliflozin is a promising new treatment option for chronic SIAD-induced hyponatremia, possibly improving neurocognitive function. Larger studies are needed to confirm the observed treatment effects. Clinical Trial registration number: ClinicalTrials.gov NCT03202667.
Generalized quasitopological gravity

We construct the most general, to cubic order in curvature, theory of gravity whose (most general) static spherically symmetric vacuum solutions are fully described by a single field equation. The theory possesses the following remarkable properties: (i) It has a well-defined Einstein gravity limit, (ii) it admits “Schwarzschild-like” solutions characterized by a single metric function, (iii) on maximally symmetric backgrounds it propagates the same degrees of freedom as Einstein’s gravity, and (iv) Lovelock and quasitopological gravities, as well as the recently developed Einsteinian cubic gravity [Bueno and Cano Phys. Rev. D 94, 104005 (2016). PRVDAQ2470-001010.1103/PhysRevD.94. 104005] in four dimensions, are recovered as special cases. We perform a brief analysis of asymptotically flat black holes in this theory and study their thermodynamics.
IL-2-based approaches to Treg enhancement

Summary Immune homeostasis is heavily dependent on the action of regulatory T cells (Tregs) which act to suppress the activation of many immune cell types including autoreactive conventional T cells. A body of evidence has shown that Tregs are intrinsically defective in many common autoimmune diseases, and gene polymorphisms which increase the susceptibility of autoimmune disease development have implicated the interleukin-2 (IL-2) signaling pathway as a key dysregulated mechanism. IL-2 is essential for Treg function and survival, and Tregs are highly sensitive to low levels of this cytokine in their environment. This review will revisit the rationale behind using low-dose IL-2 as a therapy to treat autoimmune diseases and evaluate the outcomes of trials to date. Furthermore, novel engineered IL-2 therapies with increased Treg specificity have shown promise in pre-clinical studies and human clinical trials for some agents have begun. Future studies will determine whether low-dose IL-2 or engineered IL-2 therapies can change the course of autoimmune and inflammatory diseases in patients.
Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations

Abstract Objectives Myeloid cells with a monocyte/macrophage phenotype are present in large numbers in the RA joint, significantly contributing to disease; however, distinct macrophage functions have yet to be elucidated. This study investigates the metabolic activity of infiltrating polarized macrophages and their impact on pro-inflammatory responses in RA. Methods CD14+ monocytes from RA and healthy control (HC) bloods were isolated and examined ex vivo or following differentiation into ‘M1/M2’ macrophages. Inflammatory responses and metabolic analysis ± specific inhibitors were quantified by RT-PCR, western blot, Seahorse XFe technology, phagocytosis assays and transmission electron microscopy along with RNA-sequencing (RNA-seq) transcriptomic analysis. Results Circulating RA monocytes are hyper-inflammatory upon stimulation, with significantly higher expression of key cytokines compared with HC (P < 0.05) a phenotype which is maintained upon differentiation into mature ex vivo polarized macrophages. This induction in pro-inflammatory mechanisms is paralleled by cellular bioenergetic changes. RA macrophages are highly metabolic, with a robust boost in both oxidative phosphorylation and glycolysis in RA along with altered mitochondrial morphology compared with HC. RNA-seq analysis revealed divergent transcriptional variance between pro- and anti-inflammatory RA macrophages, revealing a role for STAT3 and NAMPT in driving macrophage activation states. STAT3 and NAMPT inhibition results in significant decrease in pro-inflammatory gene expression observed in RA macrophages. Interestingly, NAMPT inhibition specifically restores macrophage phagocytic function and results in reciprocal STAT3 inhibition, linking these two signalling pathways. Conclusion This study demonstrates a unique inflammatory and metabolic phenotype of RA monocyte-derived macrophages and identifies a key role for NAMPT and STAT3 signalling in regulating this phenotype.
A Quality Assessment of Aquaporin-4 & Myelin Oligodendrocyte Glycoprotein Antibody Testing

ABSTRACT: Background: Accurate anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody assays are needed to effectively diagnose neuromyelitis optica spectrum disorder and MOG antibody-associated disease. A proportion of patients at our centre have been tested for anti-AQP4 and anti-MOG autoantibodies locally, followed by an outsourced test as part of real-world practice. Outsourced testing is costly and of unproven utility. We conducted a quality improvement project to determine the value of outsourced testing for anti-AQP4 and anti-MOG autoantibodies. Methods: All patients seen by Calgary neurological services who underwent cell-based testing for anti-AQP4 and/or anti-MOG autoantibodies at both MitogenDx (Calgary, AB) and Mayo Clinic Laboratories (Rochester, MN, USA) between 2016 and 2020 were identified from a provincial database. The interlaboratory concordance was calculated by pairing within-subject results collected no more than 365 days apart. Retrospective chart review was done for subjects with discordant results to determine features associated with discordance and use of outsourced testing. Results: Fifty-seven anti-AQP4 and 46 anti-MOG test pairs from January 2016 to July 2020 were analyzed. Concordant tests pairs comprised 54/57 (94.7%, 95%CI 88.9–100.0%) anti-AQP4 and 41/46 (89.1%, 95%CI 80.1–98.1%) anti-MOG results. Discordant anti-AQP4 pairs included two local weak positives (negative when outsourced) and one local negative (positive when outsourced). Discordant anti-MOG pairs were all due to local weak positives (negative when outsourced). Conclusion: Interlaboratory discordant results for cell-based testing of anti-AQP4 autoantibodies were rare. Local anti-MOG weak positive results were associated with discordance, highlighting the need for cautious interpretation based on the clinical context. Our findings may reduce redundant outsourced testing.
Organ‐specific effects on target binding due to knockout of thyroid hormone receptor α during Xenopus metamorphosis

Thyroid hormone (T3) is essential for normal development and metabolism, especially during postembryonic development, a period around birth in mammals when plasma T3 levels reach their peak. T3 functions through two T3 receptors, TRα and TRβ. However, little is known about the tissue‐specific functions of TRs during postembryonic development because of maternal influence and difficulty in manipulation of mammalian models. We have studied Xenopus tropicalis metamorphosis as a model for human postembryonic development. By using TRα knockout (Xtr·thratmshi) tadpoles, we have previously shown that TRα is important for T3‐dependent intestinal remodeling and hindlimb development but not tail resorption during metamorphosis. Here, we have identified genes bound by TR in premetamorphic wild‐type and Xtr·thratmshi tails with or without T3 treatment by using chromatin immunoprecipitation–sequencing and compared them with those in the intestine and hindlimb. Compared to other organs, the tail has much fewer genes bound by TR or affected by TRα knockout. Bioinformatic analyses revealed that among the genes bound by TR in wild‐type but not Xtr·thratmshi organs, fewer gene ontology (GO) terms or biological pathways related to metamorphosis were enriched in the tail compared to those in the intestine and hindlimb. This difference likely underlies the drastic effects of TRα knockout on the metamorphosis of the intestine and hindlimb but not the tail. Thus, TRα has tissue‐specific roles in regulating T3‐dependent anuran metamorphosis by directly targeting the pathways and GO terms important for metamorphosis.
Expansions at small Reynolds numbers for the flow past a sphere and a circular cylinder

This paper is concerned with the problem of obtaining higher approximations to the flow past a sphere and a circular cylinder than those represented by the well-known solutions of Stokes and Oseen. Since the perturbation theory arising from the consideration of small non-zero Reynolds numbers is a singular one, the problem is largely that of devising suitable techniques for taking this singularity into account when expanding the solution for small Reynolds numbers. The technique adopted is as follows. Separate, locally valid (in general), expansions of the stream function are developed for the regions close to, and far from, the obstacle. Reasons are presented for believing that these ‘Stokes’ and ‘Oseen’ expansions are, respectively, of the forms $\Sigma \;f_n(R) \psi_n(r, \theta)$ and $\Sigma \; F_n(R) \Psi_n(R_r, \theta)$ where (r, θ) are spherical or cylindrical polar coordinates made dimensionless with the radius of the obstacle, R is the Reynolds number, and $f_{(n+1)}|f_n$ and $F_{n+1}|F_n$ vanish with R. Substitution of these expansions in the Navier-Stokes equation then yields a set of differential equations for the coefficients ψn and Ψn, but only one set of physical boundary conditions is applicable to each expansion (the no-slip conditions for the Stokes expansion, and the uniform-stream condition for the Oseen expansion) so that unique solutions cannot be derived immediately. However, the fact that the two expansions are (in principle) both derived from the same exact solution leads to a ‘matching’ procedure which yields further boundary conditions for each expansion. It is thus possible to determine alternately successive terms in each expansion. The leading terms of the expansions are shown to be closely related to the original solutions of Stokes and Oseen, and detailed results for some further terms are obtained.
The muscle shortening maneuver in individuals with stroke: a consideration-of-concept randomized pilot trial

ABSTRACT Background and Purpose The Muscle Shortening Maneuver (MSM) is derived from Feldman’s λ model of motor control, and seems to induce a more balanced agonist- antagonist-muscular action. The hypothesized mechanism of action is a modulation of the Tonic Stretch Reflex Threshold (TSRT). We designed a pilot, randomized trial aimed to explore the mechanisms of action of the technique. An ancillary objective was to research the implementation of the MSM as a stroke rehabilitation intervention. Methods A sample of 10 participants with chronic stroke was enrolled and randomly assigned to MSM (n, 5) or conventional physical therapy (CPT) (n, 5) treatments. The TSRTs were assessed by the Montreal Spasticity Measure device. A selection of clinical and instrumental outcome measures was taken to investigate function and activity levels. Data were collected at baseline, end-of-treatment, and one month after the end-of-treatment. Results No adverse events were observed. In both between- and within-group post-treatment assessments, in the affected ankle the MSM group showed decreased TSRTs of the plantar flexor, increased strength of the dorsiflexor and active range of motion; also, the time needed to perform the Timed Up and Go test decreased. No changes were evident across assessments in the CPT group. Discussion and Conclusions The MSM seems able to modulate the TSRTs in individuals with stroke. Although with the limitations due to the pilot design, the variation in participants’ responses appear to be promising. Many methodological issues have to be clarified and specified conceiving the progression toward a confirmatory trial.
Effect of experimental stress and cortisol release induced by ACTH administration on expression of key genes related to milk synthesis and apoptosis during mammary involution of Saanen goats

Abstract This research paper addresses the hypothesis that stress, induced by ACTH administration and cortisol release increases somatic cell count (SCC) in mammary secretion, and improves the effectiveness of dry off in goats. We report indicators of milk synthesis and mammary gland involution during dry off. Thirty Saanen goats were subjected to abrupt dry off and treatments: (1) ACTH administration (ACTH) or (2) placebo (Control) on days 1, 3, 6, 9, 12, 15, 30, and 60 of dry off. The expression of target genes in mammary tissue that are related to milk synthesis and cell survival such as insulin-like growth factor 1 receptor (IGF1R), phosphatidylinositol-3-kinase (PIK3CA), protein kinase B (AKT1) and mechanistic target of rapamycin (MTOR), casein (CSN2), lactalbumin (LALBA) and lactoferrin (LF) were evaluated, and plasma cortisol concentration, SCC, leucocyte count, and microbiological analyses in milk and mammary secretions were assessed. ACTH significantly downregulated the expression of IGF1R and upregulated the expression of PIK3CA in mammary tissue, increased lactoferrin concentration and SCC, and changed immune cell levels in mammary secretions compared to Control. Furthermore, ACTH administration increased the percentage of dry goats compared to the Control (73 vs. 46%, respectively). We conclude that the effect of stress via ACTH administration and cortisol release accelerated mammary involution during the early dry-off period.
Granular motor in the non-Brownian limit

In this work we experimentally study a granular rotor which is similar to the famous Smoluchowski–Feynman device and which consists of a rotor with four vanes immersed in a granular gas. Each side of the vanes can be composed of two different materials, creating a rotational asymmetry and turning the rotor into a ratchet. When the granular temperature is high, the rotor is in movement all the time, and its angular velocity distribution is well described by the Brownian limit discussed in previous works. When the granular temperature is lowered considerably we enter the so-called single kick limit, where collisions occur rarely and the unavoidable external friction causes the rotor to be at rest for most of the time. We find that the existing models are not capable of adequately describing the experimentally observed distribution in this limit. We trace back this discrepancy to the non-constancy of the deceleration due to external friction and show that incorporating this effect into the existing models leads to full agreement with our experiments. Subsequently, we extend this model to describe the angular velocity distribution of the rotor for any temperature of the gas, and obtain a very good agreement between the model and experimental data.
Association between employment status and quality of life for individuals with intellectual or developmental disability

Abstract The current study examined how employment conditions (competitive employment, work center employment, unemployment) are associated with the quality of life (QoL) for individuals with intellectual or developmental disabilities. Using the Comprehensive Quality of Life Scale – Intellectual/Cognitive Disability (5th Edition; ComQoL‐I5; Cummins, 1997a) to measure objective QoL factors, and the PWI‐ID (Personal Wellbeing Index – Intellectual Disability, 3rd Edition; Cummins & Lau, 2005b) to measure subjective well‐being, participants answered self‐reporting questions regarding the seven QoL domains. Kruskal–Wallis H for Oneway Analysis of Variance was used to determine statistical significance between comparison work conditions. Results indicate significant findings in the objective QoL domains of Material Well‐Being, Productivity, and Safety between the work conditions for individuals with intellectual and developmental disabilities, with participants in the competitive‐employment group reporting the highest QoL objective scores in these areas. Implications of these findings for practice and research are discussed.
Dynamic changes of hematological indices in oropharyngeal cancer patients treated with radiotherapy

Abstract Background Hematological indices assist in predicting clinical outcomes. Objectives To explore changes of hematological indices on oropharynx squamous cell carcinoma (OPSCC) patients received radiotherapy and their association with survival. Material and methods The white blood cell count (WBC), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), hemoglobin (Hb), platelet (Plt), albumin (Alb), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) at baseline, 1-, 3-, 6- and 12-months follow-up were retrospectively collected. The trajectory of indices was described. A linear model with random effects was to describe indices’ changing rate and trend. Univariable Cox analysis was to assess the correlation between indices and survival. Results Of the 85 patients, WBC and ALC dropped during acute phase and gradually recovered, while NLR and PLR increased during acute phase and subsequently declined (all p < .01). Higher absolute value of nutritional indices (Alb and Hb) was associated with better prognosis (p < .05). In contrast, patients with higher absolute value or upward trend of inflammatory indices (ANC, Plt, NLR and PLR) had worse survival (p < .05). Conclusions and significance The short- and long-term changes of indices differed in OPSCC patients received radiotherapy, and absolute values and dynamic changes of indices had the potential to be prognostic factors.
A receptor-binding domain-based nanoparticle vaccine elicits durable neutralizing antibody responses against SARS-CoV-2 and variants of concern

ABSTRACT Numerous vaccines have been developed to address the current COVID-19 pandemic, but safety, cross-neutralizing efficacy, and long-term protectivity of currently approved vaccines are still important issues. In this study, we developed a subunit vaccine, ASD254, by using a nanoparticle vaccine platform to encapsulate the SARS-CoV-2 spike receptor-binding domain (RBD) protein. As compared with the aluminum-adjuvant RBD vaccine, ASD254 induced higher titers of RBD-specific antibodies and generated 10- to 30-fold more neutralizing antibodies. Mice vaccinated with ASD254 showed protective immune responses against SARS-CoV-2 challenge, with undetectable infectious viral loads and reduced typical lesions in lung. Besides, neutralizing antibodies in vaccinated mice lasted for at least one year and were effective against various SARS-CoV-2 variants of concern, including B.1. 1.7 (Alpha), B.1. 351 (Beta), P.1 (Gamma), B.1. 617.2 (Delta), and B.1. 1.529 (Omicron). Furthermore, particle size, polydispersity index, and zeta-potential of ASD254 remained stable after 8-month storage at 4°C. Thus, ASD254 is a promising nanoparticle vaccine with good immunogenicity and stability to be developed as an effective vaccine option in controlling upcoming waves of COVID-19.