Miracle-dz/UniFAR-FTUs huggingface dataset:
Insecticide Concentrations in Ecosystem Components of an Intensively Cultivated Watershed in Mississippi

ABSTRACT Concentrations of three currently used insecticides (fenvalerate, permethrin, and methyl parathion) were documented in major watershed components of Moon Lake, Mississippi and its 166 km2 watershed over a three year period. Moon Lake (10.1 km2), an oxbow of the Mississippi River, receives flow through a series of wetlands from a flatland watershed intensively cultivated in cotton, soybeans, and rice. None of the three insecticides were detected in watershed soils, but they were found sporadically in wetland and lake sediments, water and fish. Twenty-six percent of the 110 fish collected had measurable concentrations of the insecticides. Detection of all three insecticides, especially methyl parathion, in fish tissue suggested that they have sufficient persistence for uptake and, perhaps, bioaccumulation. The occurrence of banned organochlorine insecticides in the ecosystem was also observed, especially during runoff, and it also indicated the importance of watershed management practices on long t.
The Importance of Muscle Versus Fat Mass in Sarcopenic Obesity: A Re-evaluation Using D3-Creatine Muscle Mass Versus DXA Lean Mass Measurements.

BACKGROUND The combination of sarcopenia and obesity has been associated with physical impairment in older people. However, previous research has relied on assessments of lean mass as a surrogate for muscle mass. We postulate that inaccurate measures of muscle mass may have obscured the role of obesity in sarcopenia and related outcomes. Our aim was to clarify the interactions of muscle and fat with physical performance and adverse outcomes using an accurate measure of muscle mass. METHODS In a longitudinal study of >1,300 older men (mean age 84 years), we compared a direct measurement of muscle mass (D3 creatine dilution; D3Cr) with an approximation of muscle mass (appendicular lean mass [ALM] by dual-energy x-ray absorptiometry [DXA]) and their associations with measures of physical performance (gait speed, chair stand time) and adverse outcomes (incident injurious falls and mobility problems). We measured percent fat mass by DXA. RESULTS Low D3Cr muscle mass was strongly associated with decreased performance and increased risk of adverse outcomes. Increased fat mass had little association after accounting for D3Cr muscle mass. In contrast, DXA ALM was minimally associated with performance or adverse outcomes, and fatness remained associated with both outcomes after accounting for DXA ALM. CONCLUSIONS When an accurate assessment of muscle mass (rather than lean mass) is used, reduced muscle mass is highly associated with important outcomes and the negative effects of adiposity are minimal, suggesting that obesity has little relevance for the understanding of important adverse health outcomes of sarcopenia in older men.
IL-12 from endogenous cDC1, and not vaccine DC, is required for Th1 induction

Success of DC vaccines relies on the quality of antigen presentation, costimulation, lymph node migration, and the release of IL-12, in case of Th1 priming. Here, we provide evidence for interaction between the injected vaccine DCs with endogenous lymph node–resident DCs for Th1 induction. While migration of the injected DCs was essential for antigen delivery to the lymph node, the injected DCs contributed only partially to Th0 priming and were unable to instruct Th1 generation. Instead, we provide evidence that the lymph node–resident XCR1+ DCs are activated by the injected DCs to present the cognate antigen and release IL-12 for Th1 polarization. The timing of interactions in the draining lymph nodes appeared step-wise as (a) injected DCs with cognate T cells, (b) injected DCs with bystander DCs, and (c) bystander DCs with T cells. The transcriptome of the bystander DCs showed a downregulation of Treg- and Th2/Th9-inducing genes and self-antigen presentation, as well as upregulation of MHC class II and genes required for Th1 instruction. Together, these data show that injected mature lymph node migratory DCs direct T cell priming and bystander DC activation, but not Th1 polarization, which is mediated by endogenous IL-12p70+XCR1+ resident bystander DCs. Our results are of importance for clinical DC-based vaccinations against tumors where endogenous DCs may be functionally impaired by chemotherapy.
Shifts in dominance of native and invasive plants in experimental patches of vegetation

Abstract While it is widely accepted that disturbance often promotes the process of plant invasion, few data are available on specific relationships between different types of disturbance and success of plant invaders. Nor is much known about variation in invader behaviour in response to changing composition of the dominant native species in the recipient habitats. In the middle Main valley near Wurzburg (Germany), two invasive Brassicaceae forbs, Bunias orientalis and Rorippa austriaca , are frequently associated with a small number of dominant native species in the herbaceous vegetation of productive, disturbed sites. Variation in the relative dominance of these species suggests high variability between sites in the factors influencing the local invasion process. In our study, we examined variation in regeneration mode, type and frequency of disturbance, and native species composition, and considered life history differences between the two invasive species as factors contributing to the distinct dominance patterns. These factors were tested in a controlled field experiment in which individuals of the two invasive species and four native species were grown in mixed stands for almost 3 years. The development of the plants was monitored by cover values and all plants were harvested at the end of the study. All factors investigated contributed considerably to the development of distinct dominance patterns in the species mixtures. Relative to the natives, both invasive species were promoted by regeneration from vegetative fragments as compared to development from sexual offspring. While both invasive species were generally promoted by disturbance relative to the natives, they differed in their response to distinct types of disturbance, and these differences were strongly affected by species composition. Our results indicate that invasion success of R. austriaca may depend more on soil disturbance, soil transport and deposition, while B. orientalis is expected to particularly expand at mown sites that do not have dense cover by meadow grasses. Whether the native resident vegetation is mainly composed of successional competitors that suffer from disturbance or of ruderal competitors that compete early and strongly with the invasive species may be of critical importance for invasion by the two species.
Characterization of Maca (Lepidium meyenii/Lepidium peruvianum) Using a Mass Spectral Fingerprinting, Metabolomic Analysis, and Genetic Sequencing Approach

Abstract Maca (Lepidium meyenii, synonym L. peruvianum) was analyzed using a systematic approach employing principal component analysis of flow injection mass spectrometry fingerprints (no chromatographic separation) to guide the selection of samples for metabolite profiling and DNA next generation sequencing. Samples consisted of 39 commercial maca supplements from 11 manufacturers, 31 unprocessed maca tubers grown in Peru and China, and a historic non-tuber maca sample from Peru. Principal component analysis of flow injection mass spectrometry fingerprints initially placed all the maca samples in three classes with similar chemical composition: commercial maca samples, tubers grown in Peru, and tubers grown in China. Metabolite profiling identified 67 compounds in the negative mode and 51 compounds in the positive mode. Compounds identified by metabolite profiling (macamides, glucosinolates, amino acids, fatty acids, polyunsaturated fatty acids, saccharides, imidazoles) were then used to identify ions in the flow injection mass spectrometry fingerprints. The tuber fingerprints were analyzed by factorial multivariate analysis of variance revealing that black, red, and yellow maca from Peru and black and yellow maca from China were compositionally different with respect to color and country. Critical ions were identified that allowed for the differentiation of maca between colors from the same country or between two countries with the same color. Genetically, all samples were confirmed to be L. meyenii based on next generation sequencing at three gene regions (ITS2, psbA, and trnL) and comparison to recorded sequences of vouchered standards.
The Behavioral Variant Frontotemporal Dementia Phenocopy Syndrome: A Review

Objectives: The relatively recent identification of a subgroup of patients with apparent behavioral variant frontotemporal dementia (bvFTD) that fails to progress with time has led to a reevaluation of our understanding of bvFTD, and a growing body of research that attempts to characterize the mimic or “phenocopy” syndrome. In this article, we review the literature relating to the phenocopy syndrome, focusing in particular on distinguishing characteristics and potential etiologies. Methods: Published articles were identified via a systematic search of PubMed and Embase. Observational and interventional studies, case reports, and case series were sought for inclusion. Results: While bvFTD and the phenocopy syndrome are clinically indistinguishable at initial presentation, the presence or absence of characteristic changes on neuroimaging predicts 2 very different illness trajectories. The etiology for the phenocopy presentation remains uncertain. It is likely that the syndrome represents a heterogenous assortment of clinical frontal syndromes encompassing atypical neurodegenerative, psychiatric, psychological, and as yet unknown neuropsychiatric causes. Conclusions: Although the prognosis of the phenocopy syndrome is generally held to be more favorable than that of bvFTD, patients and families are subject to major disruption in their relationships and social and occupational functioning. Early recognition is crucial to facilitate timely interventions aimed at maintaining relationships, roles, and quality of life of those affected.
Indeterminate thyroid nodules in the era of molecular genomics

Indeterminate thyroid nodules are diagnosed in up to 30% of fine‐needle aspirations and the risk of malignancy in these cases are highly variable. Consequently, managing these nodules has been a challenge. While a diagnostic thyroidectomy would help clarify the pathology, there is the risk of developing surgical‐related complications for a procedure that may not have been necessary and associated high costs. Genomic testing of indeterminate thyroid nodules may help better guide management.
The ideological divide in public perceptions of self-driving cars

Applications in artificial intelligence such as self-driving cars may profoundly transform our society, yet emerging technologies are frequently faced with suspicion or even hostility. Meanwhile, public opinions about scientific issues are increasingly polarized along the ideological line. By analyzing a nationally representative panel in the United States, we reveal an emerging ideological divide in public reactions to self-driving cars. Compared with liberals and Democrats, conservatives and Republicans express more concern about autonomous vehicles and more support for restrictively regulating autonomous vehicles. This ideological gap is largely driven by social conservatism. Moreover, both familiarity with driverless vehicles and scientific literacy reduce respondents’ concerns over driverless vehicles and support for regulation policies. Still, the effects of familiarity and scientific literacy are weaker among social conservatives, indicating that people may assimilate new information in a biased manner that promotes their worldviews.
New carnivorous sponges (Porifera, Poecilosclerida) collected from manned submersibles in the deep Pacific

The subgenus Helophloeina Topsent, 1929 and the genus Abyssocladia Levi, 1964 are revived and redefined, with an identification key for Abyssocladia which at present includes seven species. Eight of the sponges were collected from the French IFREMER manned submersible Nautile near active hydrothermal sites of the East Pacific Rise and of the North Fiji and Lau Basins, one from the Russian submersible Mir 2 in the Northwest Pacific near Bering Island, and one from the US submersible Alvin south of Easter Island. Their life conditions are described from direct observations from the submersibles. Some remarks are presented on the taxonomy of Cladorhizidae and more generally of carnivorous Poecilosclerida. The study suggests a very high degree of diversity in the deep Pacific carnivorous sponges. © 2006 The Linnean Society of London, Zoological Journal of the Linnean Society , 2006, 148 , 553‐584.
Felt Emotion Elicited by Music: Are Sensitivities to Various Musical Features Different for Young Children and Young Adults?

Abstract In the present study, we extended the issue of how people access emotion through nonverbal information by testing the effects of simple (tempo) and complex (timbre) acoustic features of music on felt emotion. Three- to six-year-old young children (n = 100; 48% female) and university students (n = 64; 37.5% female) took part in three experiments in which acoustic features of music were manipulated to determine whether there are links between perceived emotion and felt emotion in processing musical segments. After exposure to segments of music, participants completed a felt emotion judgment task. The chi-square test showed significant tempo effects, ps < . 001 (Exp. 1), and strong combined effects of mode and tempo on felt emotion. In addition, strength of these effects changed across age. However, these combined effects were significantly stronger under the tempo-and-mode consistent condition, ps < . 001 (Exp. 2) than inconsistent condition (Exp. 3). In other words, simple versus complex acoustic features had stronger effects on felt emotion, and that sensitivity to these features, especially complex features, changed across age. These findings suggest that felt emotion evoked by acoustic features of a given piece of music might be affected by both innate abilities and by the strength of mappings between acoustic features and emotion.
Estimation of Small‐Mammal Population Size

Two methods of estimating small-mammal population size from multiple capture-mark-recapture occasions, the Lincoln-Petersen estimator and program CAP- TURE, were evaluated and compared using computer simulation. Comparisons were made for population sizes of 50, 75, and 100, trapping periods of 5, 7, and 10 d and numerous patterns of capture probabilities. Program CAPTURE often failed to provide useful esti- mates of population size due to the poor performance of its model selection procedure. The Lincoln-Petersen estimator provides estimates of population size with low biases and standard errors except when uniform behavioral response occurs or when there is high heterogeneity in individual capture probabilities. We suggest that researchers use CAP- TURE as a screening technique to check for evidence of uniform trap responses and/or high individual heterogeneity in capture probabilities. If these influences are not present, the Lincoln-Petersen estimator may be the best method for estimation of small-mammal population size.
Live Donor Liver Transplantation in the United States: Impact of Share 35 on Live Donor Utilization.

BACKGROUND Share 35 was a policy implemented in 2013 to increase regional sharing of deceased donor livers to patients with MELD ≥ 35 in order to decrease waitlist mortality for the sickest patients awaiting liver transplantation. The purpose of this study was to determine whether LDLT volume was impacted by the shift in allocation of deceased donor livers to patients with higher MELD scores. METHODS Using UNOS/OPTN Standard Transplant Analysis and Research files, we identified all adults who received a primary LT between October 1, 2008 and March 31, 2018. LT from October 1, 2008 through June 30, 2013 were designated as the pre-Share 35 era and July 1, 2013 through March 31, 2018 as the post-Share 35 era. Primary outcomes included transplant volumes, graft survival, and patient survival in both eras. RESULTS 48,779 primary adult single-organ LT occurred during the study period (22,255 pre-Share 35, 26,524 post. LDLT increased significantly (6.8% post vs. 5.7% pre, p<0.001). LDLT volume varied significantly by region (p<0.001) with regions 2, 4, 5, and 8 demonstrating significant increases in LDLT volume post-Share 35. The number of centers performing LDLT increased only in regions 4, 6, and 11. Throughout the two eras, there was no difference in graft or patient survival for LDLT recipients. CONCLUSIONS Overall LDLT volume increased following the implementation of Share 35 which was largely due to increased LDLT volume at centers with experience in LDLT, and corresponded to significant geographic variation in LDLT utilization.
Wall Lizards Modulate Refuge Use through Continuous Assessment of Predation Risk Level

Prey species might use several possible ways to assess predation risk when encountering a predator. Animals may consider the risk level estimated in a first encounter to remain unchanged across subsequent encounters (fixed risk response), or they may update and change their responses across encounters in accordance with short-term changes in risk levels (flexible risk response). We examined in the field how wall lizards assess risk level by analyzing time spent in refuges after simulated predator attacks. We first examined how risk was assessed when multiple consecutive sources of risk were present simultaneously. The results suggest that wall lizards assess risk based on multiple cues, such as approach speed, directness, and persistence (measured as the distance of the predator to their refuge after an attack). When risk was high lizards remained longer in their refuges. The first decision to appear partly from the refuge depended on both approach speed and persistence, whereas the decision to emerge completely depended only on persistence and not on approach speed. This suggests that wall lizards update information on predator threat and adjusted their emergence accordingly. In a second experiment, we analyzed how short-term changes in risk level of successive attacks affected refuge use. Successive emergence times varied as a function of current risk level of each repeated attack, independently of the risk level of previous attacks. This indicated that lizards could track short-term changes in risk level through time and modify their initial responses when required. Fine adjustments of refuge use may help lizards to minimize costs of refuge use in unfavorable and variable environments where antipredatory responses are costly.
A new genus of Parabathynellidae (Crustacea: Bathynellacea) in New South Wales, Australia

A new genus and species of the family Parabathynellidae, Octobathynella peelensis gen. nov. sp. nov., is described from New South Wales, Australia. The new genus displays several exclusive characters: a very large and distinctive male thoracopod VIII with one crest-like projection containing two lobules on the basipod; and four aesthetascs on segments six and seven of the antennule. It also has several combinations of characters that make it unique in the Parabathynellidae, specifically that: the antennule is eight-segmented (a new character in the Australian species); there are seven segments in the antenna; the labrum has 18–20 teeth; the exopod of thoracopod I has three to four segments and the exopod of thoracopod II has four segments; the endopod has one dorsal seta on the first and second segments and the epipod is absent on thoracopod I; pleopods are absent; the endopod of the male thoracopod VIII has two setae and the exopod has setules; there are 10–12 spines on the sympod, three or four spines on the endopod and five setae on the exopod of the uropod. The new genus and species is placed into context with all known Bathynellacea in Australia, and the biogeographic patterns are discussed for this ancient group of subterranean crustaceans.
Impact of the COVID-19 Pandemic on Orthopaedic and Trauma Surgery in University Hospitals in Germany: Results of a Nationwide Survey.

BACKGROUND The purpose of the present study was to assess the impact of the coronavirus disease 2019 (COVID-19) pandemic on orthopaedic and trauma surgery departments in university hospitals in Germany in order to clarify current challenges. METHODS In this cross-sectional study, an online-based anonymous survey was conducted within the Convention of University Professors of Orthopaedic and Trauma Surgery in Germany from April 3 to April 11, 2020. A bipolar 5-point Likert scale (with possible responses of "totally disagree," "rather disagree," "neutral," "rather agree," and "totally agree") was applied. Fifty-two (69.3%) of 75 clinic directors participated. RESULTS Communication and cooperation with the government, hospital administration, and other departments during the COVID-19 pandemic were mainly perceived as appropriate. However, only 7 respondents (13.7%) totally agreed or rather agreed with the statement that the authorities are supporters of orthopaedic and trauma surgery departments. Substantial financial and personnel changes in orthopaedic and trauma surgery departments of university hospitals were reported, resulting in an average reduction of 49.4% in operating room capacity and an expected 29.3% loss of revenue. In addition, 14.7% of physicians were reallocated from orthopaedic and trauma surgery to other care-delivery environments. CONCLUSIONS Our study demonstrated that the COVID-19 pandemic has had a substantial impact on orthopaedic and trauma surgery departments in German university hospitals. Distinct structural and financial effects were noted. Nevertheless, the present study demonstrates the commitment of our specialty to overcome the pandemic by providing competent personnel as well as close cooperation with the hospital administration and other departments. CLINICAL RELEVANCE To our knowledge, this is the first Germany-wide survey among the heads of orthopaedic and trauma surgery departments in university hospitals on the impact of the COVID-19 pandemic. The survey results may help to inform system-wide decision-making in Germany, in Europe, and beyond.
Evaluation of Live Feeds for Larval and Postlarval Mahimahi Coryphaena hippurus

Live hatchery feeds were assayed for fatty acids (FA), amino acids (AA), and their ability to support growth and survival of larval and postlarval mahimahi Coryphaena hippurus at two different hatchery stages. Euterpina acuritrons copepods (C), mahimahi yolk-sac larvae (YSL), Artemia parthenogenica brine shrimp nauplii (BSn), A. parthenogenica juveniles (BSj), and Brachionus plicatilis rotifers (R) were assayed, using several enrichment media. There was little difference in AAs among feeds. Levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were about 10 times higher in YSL than in their feeds. This explains previous findings where first stage larval survival (0–9 days) was not affected by feed HUFA levels. Second stage survival was significantly higher when larvae were fed copepods. Enrichment with 100 ppm SuperSelco greatly improved the survival of larvae that were fed brine shrimp. The even higher omega-3 fatty acids found in copepods appear to be important for survival of larvae under more stressful conditions. Brine shrimp juveniles enriched with SuperSelco are a good food for postlarval mahimahi. Yolksac larvae of mahimahi are an even better food, promoting faster growth at less cost, for large scale mahimahi aquaculturists. Different batches of yolksac mahimahi larvae varied by a factor of 10 in their concentration of DHA, but always had the highest level of DHA as much as 40% of total fatty acids (FAs). These “high HUFA” batches of YSL also had the highest levels of EPA and total fatty acids. The data suggest that climate and broodstock age may have considerable influence on larval nutrition.