Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Myofilament Ca 2 (cid:49) -Sensitizing Property of Xanthine Oxidase Inhibitors

—Antioxidants are known to mitigate the cardiac contractile dysfunction that follows brief periods of ischemia (“myocardial stunning”). Stunning decreases contractility at the level of the contractile proteins; therefore, we asked whether antioxidant treatment preserves myofilament Ca 2 (cid:49) responsiveness after global ischemia and reflow. Right ventricular trabeculae were dissected from rat hearts subjected either to 20 minutes ischemia and reperfusion in the absence of drugs (stunned group) or to the same protocol in the presence of allopurinol, an inhibitor of xanthine oxidase (XO), and mercaptopropionylglycine (MPG), a hydroxyl radical scavenger (antioxidant group). At 20 minutes of reflow, isovolumic developed pressure recovered completely in the antioxidant group, but in the stunned group it recovered by only 57%. [Ca 2 (cid:49) ] i and contractile force measurements in trabeculae revealed the expected depression of myofilament function in the stunned group, with no change in Ca 2 (cid:49) transients relative to nonischemic controls. In contrast, Ca 2 (cid:49) transients were smaller, but force was greater, in the antioxidant group relative to both the stunned group and to nonischemic controls. Steady-state [Ca 2 (cid:49) ] i -force relationships revealed a striking increase of maximal force and a modest shift of activation to a lower range of [Ca 2 (cid:49) ] i . The increase in maximal force was reproduced by allopurinol (cid:49) MPG or by allopurinol alone under nonischemic conditions and also by oxypurinol (100 (cid:109) mol/L), a potent inhibitor of XO. We conclude that allopurinol and oxypurinol sensitize the cardiac myofilaments to Ca 2 (cid:49) . This Ca 2 (cid:49) -sensitizing effect underlies the preservation of contractility observed with an allopurinol (cid:49) MPG antioxidant cocktail in a model of stunned myocardium. These serendipitous findings identify allopurinol and oxypurinol as the lead compounds of a novel class of inotropic agents. ( Circ Res . 1998;83:423-430.)
RMHP_A_238012 633..642

1Department of Urology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 3Urology Department, First Affiliated Hospital of Xinxiang Medical University, Weihui City, Henan Province, People’s Republic of China; 4Department of Urology, Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 5Emergency Department, Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 6Department of Urology, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
Solar energy conversion via photovoltaics and photocatalysis

Due to the forthcoming shortage of natural resources, the demand for more efficient and ecofriendly chemical processes for the conversion of energy and matter, especially with respect to carbon management, is growing rapidly. Therefore, a search for high-performance solar energy conversion systems to end the current carbon economy era is of paramount importance in both academic and industrial sectors. In this regard, we have studied organic photovoltaics and solar water splitting by using oCVD (Oxidative Chemical Vapor Deposition) polymers and dopingtreated bismuth vanadate (BiVO 4), respectively. oCVD is a solvent-free conformal vacuum-based technique to enable thin-film fabrication of insoluble polymers at moderate vacuum (~ 0.1 Torr) and low temperature (25 150 'C). Moreover, oCVD carries the well-cited processing benefits of vacuum processing, such as parallel and sequential deposition, well-defined thickness control, large-area uniformity, and inline integration with other standard vacuum processes (e.g., vacuum thermal evaporation). Based on the abovementioned technical advantages from oCVD, polyselenophene and poly(3,4dimethoxythiophene) have been successfully applied to organic photovoltaics. Cost-effective solar hydrogen production requires catalytic materials that have earthabundant element composition, suitable photoelectrochemical properties, and broad technological applicability. To create this versatile catalytic material, controlling the catalyst's atomic structure is of primary importance since their functionalities (e.g., electronic band structure, catalytic activity, chemical stability, etc.) are governed by its atomic structure. According to the strategy, BiVO 4's atomic structure has been engineered via phosphorus, indium and molybdenum doping. The improved photocatalytic behavior of doping-treated BiVO 4 has been studied within experimental and computational domains. Thesis Supervisor: Karen K. Gleason Title: Associate Provost and Alexander and I. Michael Kasser Professor of Chemical Engineering 3
AREGU June 47/6

Martı́nez-Nieves, Brenda, Heidi L. Collins, and Stephen E. DiCarlo. Arterial baroreflex regulation of regional vascular conductance at rest and during exercise. Am J Physiol Regulatory Integrative Comp Physiol 278: R1634– R1642, 2000. —We tested the hypothesis that dynamic exercise resets the operating point and attenuates the spontaneous gain of the arterial baroreflex regulation of mesenteric and hindlimb vascular conductance in hypertensive rats. Eleven adult male spontaneously hypertensive rats were chronically instrumented with left carotid arterial catheters and Doppler ultrasonic flow probes around the superior mesenteric and left common iliac arteries. After the rats recovered, arterial baroreflex function was examined by recording reflex changes in conductance in response to spontaneous changes in mean arterial pressure before exercise and during steady-state treadmill running at 6 and 18 m/min. Dynamic exercise reduced the spontaneous baroreflex gain of mesenteric conductance (by 51 and 36%) and maximum mesenteric conductance (by 24 and 32%) at 6 and 18 m/min, respectively. In sharp contrast, dynamic exercise increased the spontaneous maximum iliac conductance (by 32 and 47%) without changing the spontaneous gain. Sinoaortic denervation eliminated the relationship between mean arterial pressure and conductance by reducing the mesenteric (92%) and iliac (68%) vascular conductance gain. These results demonstrate that dynamic exercise has differential effects on the regulation of mesenteric and iliac vascular conductance in hypertensive rats.
Microsoft Word-SHMT2 Pharmacodynamics Manuscript final 10-7-19 FINAL

213 Introduction: 774 Discussion: 1020 This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on November 9, 2019 as DOI: 10.1124/mol.119. 117937 at A PE T Jornals on M arch 6, 2020 m oharm . aspeurnals.org D ow nladed from
The apical scaffold big bang binds to spectrins and regulates the growth of Drosophila melanogaster wing discs

numbers are tightly regulated, ensuring that tissues and organs reach their correct size and shape. Recent evidence has highlighted the intricate connections between the cytoskeleton and the regulation of the key growth control Hippo pathway. Looking for apical scaffolds regulating tissue growth, we describe that Drosophila melanogaster big bang (Bbg), a poorly characterized multi-PDZ scaffold, controls epithelial tissue growth without affecting epithelial polarity and architecture. bbg -mutant tissues are smaller, with fewer cells that are less apically constricted than normal. We show that Bbg binds to and colocalizes tightly with the β -heavy–Spectrin/Kst subunit at the apical cortex and promotes Yki activity, F-actin enrichment, and the phosphorylation of the myosin II regulatory light chain Spaghetti squash. We propose a model in which the spectrin cytoskeleton recruits Bbg to the cortex, where Bbg promotes actomyosin contractility to regulate epithelial tissue growth.
EGFR biomarkers predict benefit from vandetanib in combination with docetaxel in a randomized phase III study of second-line treatment of patients with advanced non-small cell lung cancer

EGFR biomarkers predict benefit from vandetanib in combination with docetaxel in a randomized phase III study of second-line treatment of patients with advanced non-small cell lung cancer J. V. Heymach1, S. J. Lockwood2, R. S. Herbst3, B. E. Johnson4,5 & A. J. Ryan6* Division of Cancer Medicine, Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, USA; Oncology iMED, AstraZeneca, Macclesfield, UK; Section of Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital, Yale, New Haven; Departments of Medical Oncology; Medicine, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, USA; Department of Oncology, University of Oxford, Oxford, UK
Effect of harvest time on the compositional changes in essential oils, cannabinoids, and waxes of hemp (Cannabis sativa L.)

Demand for cannabinoid is growing, with the global market expected to reach $9.69 billion by 2025. Understanding how chemical composition changes in hemp at different harvest times is crucial to maximizing this industrial crop value. Important compositional changes in three different compound classes (essential oils, cannabinoids, and lipids) from inflorescences (tops), leaves, and stems of hemp (Cannabis sativa L., Finola variety) at different harvesting stages have been investigated. Over 85% of the total extracts from the tops were cannabinoids, while leaves demonstrated the greatest quantities of wax ester and sterols. Essential oil and cannabinoid increased in tops until full flowering (third harvest), reaching 2030 µg g−1 and 39 475 µg g−1, respectively. Cannabinoids decreased at seed maturity (final harvest) to 26 969 µg g−1. This demonstrates the importance of early harvesting to maximize cannabidiol (CBD), which is highly sought after for its therapeutic and pharmacological properties. A total of 21 161 µg g−1 of CBD was extracted from the tops at full flowering (third harvest); however, a significant increase (63%) in the banned psychoactive tetrahydrocannabinol (THC) was observed from budding (157 µg g−1 of biomass) to the full flowering (9873 µg g−1 of biomass). Harvesting the tops after budding is preferable due to the high CBD content and low amounts of THC.
Demographic consequences of heterogeneity in conspecific density dependence among mast-fruiting tropical trees

The role of conspecific density dependence (CDD) in the maintenance of species richness is a central focus of tropical forest ecology. However, tests of CDD often ignore the integrated effects of CDD over multiple life stages and their long-term impacts on population demography. We combined a 10-year time series of seed production, seedling recruitment and sapling and tree demography of three dominant Southeast Asian tree species that adopt a mast-fruiting phenology. We used these data to construct individual-based models that examine the effects of CDD on population growth rates (λ) across life-history stages. Recruitment was driven by positive CDD for all species, supporting the predator satiation hypothesis, while negative CDD affected seedling and sapling growth of two species, significantly reducing λ. This negative CDD on juvenile growth overshadowed the positive CDD of recruitment, suggesting the cumulative effects of CDD during seedling and sapling development has greater importance than the positive CDD during infrequent masting events. Overall, CDD varied among positive, neutral and negative effects across life-history stages for all species, suggesting that assessments of CDD on transitions between just two stages (e.g. seeds seedlings or juveniles mature trees) probably misrepresent the importance of CDD on population growth and stability.
Delta-type VLFS – hydrodynamic aspects

ABSTRACT A Very Large Floating Structure (VLFS) is a promising concept for the utilisation of the sea. Currently, VLFSs are classified into two broad categories: the pontoon-type, limited to sheltered water, and the semi-submersible type, for open-ocean. We present a new concept, the delta-type, an important feature of which is the formation of a sheltered basin, providing accessibility in most weather conditions. Initiating the development of this concept, we study its hydrodynamic aspects: basin efficiency, motion, comfort and mooring. We present a case study, for which we compare the hydrodynamic aspects for four configurations of equal utilisation areas. The agitation in the basin and the motion are solved linearly for regular and irregular seas. A single-point mooring system is designed and solved in the time-domain, considering the second-order slow-drift motion that is critical to the mooring loads. We obtained promising results that justify the next stage of the study – structural aspects.
Overview of Lithium-Ion battery modeling methods for state-of-charge estimation in electrical vehicles

As a critical indictor in the Battery Management System (BMS), State of Charge (SOC) is closely related to the reliable and safe operation of lithium-ion (Li-ion) batteries. Model-based methods are an effective solution for accurate and robust SOC estimation, the performance of which heavily relies on the battery model. This paper mainly focuses on battery modeling methods, which have the potential to be used in a model-based SOC estimation structure. Battery modeling methods are classified into four categories on the basis of their theoretical foundations, and their expressions and features are detailed. Furthermore, the four battery modeling methods are compared in terms of their pros and cons. Future research directions are also presented. In addition, after optimizing the parameters of the battery models by a Genetic Algorithm (GA), four typical battery models including a combined model, two RC Equivalent Circuit Model (ECM), a Single Particle Model (SPM), and a Support Vector Machine (SVM) battery model are compared in terms of their accuracy and execution time.
Symptoms, impairment and treatment needs among youth with orthostatic intolerance in a secondary care setting

ABSTRACT Studies characterizing Orthostatic Intolerance (OI) have primarily focused on a specific subtype (e.g., Postural Orthostatic Tachycardia Syndrome, POTS) treated in tertiary care, yet many with impairing symptoms do not meet subtype criteria. Study 1 used structured coding of electronic medical records to explore symptoms and impairment among 226 youth with OI in a common care setting (outpatient cardiology) over a 1-year period. Impairment was evident for 54.7% of youth. Greater impairment was associated with female gender, higher number and frequency of symptoms, and specific symptoms of headache, weakness, or exercise intolerance. Study 2 examined symptoms, functional disability, and treatment interest in a subset of youth from Study 1 (n = 75); data were collected 1–2 years after initial visit via phone interview. Fifty-six percent of participants remained symptomatic, with mean disability exceeding “substantial impairment” and most (78.6%) expressing desire for treatment. Greater disability was associated with more symptoms and the symptom of weakness. Critically, disability was more than twice as high among racial and ethnic minority youth. Results suggest that OI impairment is common among youth in secondary care, and many experience symptoms warranting treatment 1–2 years later. Future studies should identify sources of health disparities and develop efficacious treatments.
Growth curves of Nile tilapia (Oreochromis niloticus) strains cultivated at different temperatures

Growth of Red, GIFT and Supreme Nile tilapia strains were evaluated. Fish were cultivated in indoor recirculation systems in 0.5 m³ tanks with controlled temperatures of 22, 28 and 30°C. Random samples of 20 fish from each strain (10 fish tank -1 ) were weighed at day 7, 30, 60, 90 and 120. Exponential model (y=Ae Kx ) and Gompertz model (y = Aexp(-Be -Kx )) were fitted and the estimates parameters were obtained by Weighted Least Squares. At 22°C, Red, GIFT and Supreme strain presented similar growth and fit of exponential model. GIFT and Supreme strain presented higher growth rate at 30°C of cultivation when compared to Red strain. Temperature influences weight and age at the inflection point. The temperature of cultivation influences the growth description of Red, GIFT and Supreme tilapia strains. It changes the age and weight at inflection point and the qualities of growth model fits, changing the variation of the batch.
A novel equilibrium optimized double-loop control scheme for unstable and integrating chemical processes involving dead time

Abstract Integrating and unstable chemical processes showcase instability in open-loop configuration due to the existence of poles at the origin and right-half of the s-plane. They present challenging control requirements due to their non-self-regulating nature. The presence of dead time demands more sophisticated control requirements for the above-mentioned processes. So double-loop control strategies are preferred over PID controllers in single-loop configuration. In this work, a novel IMC-PD double-loop control strategy is proposed for unstable and integrating plants with dead time. The inner-loop consists of PD controller whose initial settings are derived using Routh–Hurwitz stability conditions. The outer-loop consists of an IMC controller whose parameter along with that of the PD controller is optimized using the metaheuristic algorithm called equilibrium optimizer algorithm (EOA). EOA utilizes the range of controller settings from RH criteria for stable operation and provides the optimal settings by minimizing the integral square error (ISE). Merits of the suggested strategy is illustrated with the help of benchmark plant models of unstable/integrating chemical processes and that of a bioreactor. By computing quantitative performance measures, the dynamic responses resulting from the proposed control scheme is found to be more effective than the reported works.
Predictability of cryptocurrency returns: evidence from robust tests

Abstract The paper provides a comparative empirical study of predictability of cryptocurrency returns and prices using econometrically justified robust inference methods. We present robust econometric analysis of predictive regressions incorporating factors, which were suggested by Liu, Y. , & Tsyvinski, A. (2018). Risks and returns of cryptocurrency. NBER working paper no. 24877; Liu, Y. , & Tsyvinski, A. (2021). Risks and returns of cryptocurrency. The Review of Financial Studies, 34(6), 2689–2727, as useful predictors for cryptocurrency returns, including cryptocurrency momentum, stock market factors, acceptance of Bitcoin, and Google trends measure of investors’ attention. Due to inherent heterogeneity and dependence properties of returns and other time series in financial and crypto markets, we provide the analysis of the predictive regressions using both heteroskedasticity and autocorrelation consistent (HAC) standard-errors and also the recently developed t t -statistic robust inference approaches, Ibragimov, R. , & Müller, U. K. (2010). t-statistic based correlation and heterogeneity robust inference. Journal of Business and Economic Statistics, 28, 453–468; Ibragimov, R. , & Müller, U. K. (2016). Inference with few heterogeneous clusters. Review of Economics and Statistics, 98, 83–96. We provide comparisons of robust predictive regression estimates between different cryptocurrencies and their corresponding risk and factor exposures. In general, the number of significant factors decreases as we use more robust t-tests, and the t-statistic robust inference approaches appear to perform better than the t-tests based on HAC standard errors in terms of pointing out interpretable economic conclusions. The results in this paper emphasize the importance of the use of robust inference approaches in the analysis of economic and financial data affected by the problems of heterogeneity and dependence.
Theoretical analysis of close-contact melting on superhydrophobic surfaces

Abstract The present study deals with close-contact melting of a vertical cylinder on a horizontal isothermal superhydrophobic surface with an array of circular posts. A new numerical model for this phenomenon is formulated under several simplifying assumptions. For the limiting case of perfect slip and thermal contact, based on the model assumptions, it is demonstrated that superhydrophobic surfaces can enhance the melting time by no more than 30 %. Numerical solution of the new model reveals that the effect of superhydrophobic hydrodynamic slip can decrease the molten layer thickness. However, due to the dominant effect of thermal slip, the heat transfer rate can be decreased significantly, and the melting time can be roughly doubled. An approximate analytical model is developed for understanding the problem dynamics better. The analytical model predictions are compared extensively against the numerical model results. For sufficiently low surface volume fractions, the analytical model provides excellent estimations of the numerical model predictions. Dimensional analysis reveals that according to the analytical model, the ratio between the melting times for superhydrophobic and regular surfaces is governed by a single dimensionless group. Moreover, according to the analytical model, the melting time on a superhydrophobic surface is always longer than on a regular surface, which agrees qualitatively with the numerical model results. Based on this analysis, a dimensionless condition for the analytical model range of validity is formulated. Finally, a conservative criterion for the liquid–gas interface stability under a close-contact melting process is established.
The Effect of Swarming on a Voltage Potential-Based Conflict Resolution Algorithm

Several conflict resolution algorithms for airborne self-separation rely on principles derived from the repulsive forces that exist between similarly charged particles. This research investigates whether the performance of the Modified Voltage Potential algorithm, which is based on this algorithm, can be improved using bio-inspired swarming behavior. To this end, the collision avoidance function of the algorithm is augmented with the velocity alignment and flock centering swarming traits displayed by animals such as birds and fish. The basic and swarm augmented versions of the algorithm were compared using large-scale fast time simulations, for multiple traffic demand scenarios. For ideal conditions, the results show that the process of aligning with neighboring traffic triggered a large number of conflicts. However, when noise was added to scenarios, swarming led to a lower increase in the number of intrusions, which could indicate that it can be used to improve the robustness of the Modified Voltage Potential algorithm. Furthermore, the stability results suggest that both versions of the algorithm could reduce the number of conflict chain reactions with respect to simulations without resolution. Future research will further explore the effect of conflict resolution on airspace stability, as well as whether varying the relative weights of swarming elements can improve the safety of swarm augmentations.