Miracle-dz/UniFAR-FTUs huggingface dataset:
CEOR_A_284702 747..760

1Ghimbi District Health Office, Ghimbi, Oromia, Ethiopia; 2Department of Health Policy and Management, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Oromia, Ethiopia; 3School of Public Health, Institute of Health, Wollega University, Nekemte, Oromia, Ethiopia Background: Community-based health insurance (CBHI) is a prepayment method of financial contributions for healthcare which aims to risk pooling, avoidance of catastrophic and impoverishing health expenditure. However, a high dropout from the scheme remains the biggest challenge to effective and sustainable progress towards universal financial protection in lowand middle-income countries. While large literature had examined initial enrollment and factors associated with it, only a few studies dealt with dropout. So the study aimed to assess the magnitude and determinants of dropout from community-based health insurance among households in Manna district, Jimma zone, Oromia Regional State, Ethiopia. Methods: A community-based cross-sectional study design was employed to collect data from 634 household heads from March 1 to 30, 2020. A multistage sampling technique was carried out and interviewer-administered questionnaires were used to collect data. Descriptive statistics and multivariable logistic regression analyses were performed, and variables with a P-value<0.05 were considered as having a statistically significant association with the dropout from the CBHI. Results: Magnitude of dropout from CBHI was 31.9% with 95% confidence interval (CI) =28.2–35.8% and relatively older age [adjusted odds ratio (AOR) (95% CI)=0.26 (0.10–0.78)], educational level [AOR (95% CI)=0.16 (0.06–0.41)], family size [AOR (95% CI) =0.36 (0.19–0.66)], poor perceived quality of service [AOR (95% CI)=5.7 (2.8–11.8)], trust in health facility [AOR (95% CI)=0.43 (0.3–0.61)], trust in the scheme [AOR (95% CI)=0.61 (0.45–0.84)], providers’ attitude [AOR (95% CI)=10 (4.0–25.4)], and benefit package [AOR (95% CI)=4.9 (2.4–9.9)] were statistically significant determinants associated with dropout. Conclusion: Dropout from CBHI in this study area was high. Household heads’ age, educational level, family size, perceived quality of service, providers’ attitude, a benefits package, trust in the contracted health facility, and the scheme were the significant predictors of dropout. We strongly recommend that greater efforts should be made toward the providers’ attitude, promised benefit package, and quality of services.
Isolation of Mitochondria from Soybean Leaves

A technique to isolate mitochondria from chamber-grown soybeans (Glycine max cv Williams) was developed. The mitochondria were isolated by centrifugation on discontinuous Percoll gradients which yielded a sharp band of mitochondria contaminated by only 4% of the total chlorophyll in the gradient. Contamination by peroxisomes was also slight. The isolated mitochondria oxidized malate plus glutamate, NADH, and malate with respiratory control. They also showed cyanideinsensitive, alternative pathway activity which was inhibited by salicylhydroxamic acid.
An Engineered Human Fc variant With Exquisite Selectivity for Fc (cid:13) RIIIaV158 Reveals That Ligation of Fc (cid:13) RIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages

Ligation Cellular IgG antibodies mediate the clearance of target cells via the engagement of Fc gamma receptors (Fc γ Rs) on effector cells by eliciting antibody-dependent cellular cytotoxicity and phagocytosis (ADCC and ADCP, respectively). Because (i) the IgG Fc domain binds to multiple Fc γ Rs with varying afﬁnities; (ii) even low Fc:Fc γ Rs afﬁnity interactions can play a signiﬁcant role when antibodies are engaged in high avidity immune complexes and (iii) most effector cells express multiple Fc γ Rs, the clearance mechanisms that can be mediated by individual Fc γ R are not well-understood. Human Fc γ RIIIa (hFc γ RIIIa; CD16a), which exists as two polymorphic variants at position 158, hFc γ RIIIa V158 and hFc γ RIIIa F158 , is widely considered to only trigger ADCC, especially with natural killer (NK) cells as effectors. To evaluate the role of hFc γ RIIIa ligation in myeloid-derived effector cells, and in particular on macrophages and monocytes which express multiple Fc γ Rs, we engineered an aglycosylated engineered human Fc (hFc) variant, Fc3aV, which binds exclusively to hFc γ RIIIa V158 . Antibodies formatted with the Fc3aV variant bind to the hFc γ RIIIa V158 allotype with a somewhat lower K D than their wild type IgG1 counterparts, but not to any other hFc γ R. The exceptional selectivity for hFc γ RIIIa V158 was demonstrated by SPR using increased avidity, dimerized GST-fused versions of the ectodomains of hFc γ Rs and from the absence of binding of large immune complex (IC) to CHO cells expressing each of the hFc γ Rs, including notably, the Fc γ RIIIa F158 variant or the highly homologous Fc γ RIIIb. We show that even though monocyte-derived GM-CSF differentiated macrophages express hFc γ RIIIa at substantially lower levels than the other two major activating receptors, namely hFc γ RI or hFc γ RIIa, Fc3aV-formatted Rituximab and Herceptin perform ADCP toward CD20- and Her2-expressing cancer cells, respectively, at a level comparable to that of the respective wild-type antibodies. We further show that hFc γ RIIIa activation plays a signiﬁcant role on ADCC by human peripheral monocytes. Our data highlight the utility of Fc3aV and other similarly engineered exquisitely selective, aglycosylated Fc variants toward other hFc γ Rs as tools for the detailed molecular understanding of hFc γ R biology. tumor cell death by monocyte-derived DCs via the ligation of Fc γ RI (39). In this work, we report on the engineering of an aglycosylated hFc domain, Fc3aV, that has essentially absolute speciﬁcity for the hFc γ RIIIa V158 allotype. Using antibodies equipped with the Fc3aV variant, we showed that exclusive engagement of hFc γ RIIIa results in potent ADCP with gmM φ and also established the role of this receptor on ADCC with monocytes as eﬀectors.
Bacteriological Profiles and Sensitivity Patterns in Inpatient Urine Culture Isolates

The most common nosocomial infection among hospitalized patients is Urinary Tract Infection (UTI), and this is a major health concern in developing countries. There has been documented increasing resistance to commonly used antibiotics. The aim of this research project was aimed at studying the isolates and their antibiotic resistance patterns in admitted hospital patients. The study was done in Karachi on inpatient patient urine samples of patients with clinically suspected UTIs, in order to assess the antimicrobial susceptibility pattern of different organisms, which would help in deciding empirical antibiotic treatment and improving patient outcomes. 400 urine sample reports of inpatients clinically suspected to have UTI after 3 days of hospital admission were collected from the bacteriology laboratory results, out of which 283 were culture positive. The positive samples included 183 females and 100 males. The most commonly isolated organism was Escherichia coli ( E.coli ), followed by Klebsiella species . Escherichia coli was most sensitive to meropenem (90%) and nitrofurantoin (86%) whereas Klebsiella species showed more lower susceptibility rates to commonly used antibiotics. E.coli species was the most common organism causing UTIs. Antimicrobial resistance is seen to be emerging against some antibiotics, and the current susceptibility patterns may be used locally for optimum therapeutic outcomes and for preventing antibiotic misuse.
NSS_A_328214 1653..1661

Institute of Respiratory and Critical Care, The First Hospital of China Medical University, Shenyang, People’s Republic of China Purpose: Tongue strength training (TST) has been shown to decrease the apnea-hypopnea index in some patients with obstructive sleep apnea (OSA). However, whether TST modulates the central regulation of genioglossus and influences the stability of the upper airway remains unknown. The purpose of this study was to dynamically assess the effect of TST on the upper airway. Methods: Sixteen adult male Sprague–Dawley rats were studied to explore the mechanism of TST improving the upper airway function. The rats were randomly assigned to the normal control (NC) and TST groups. The TST group underwent 8-week progressive resistance tongue exercise training. Transcranial magnetic stimulation (TMS) responses and EMG activities were consistently recorded for 2 h on days 0, 14, 28, and 56 of the experiments in both groups. Theoretical critical pressure (Pcrit) value was measured on days 0, 14, 28, and 56. Results: The TST group showed shorter TMS latency and higher genioglossus EMG activity, which lasted from 5 min to 80 min after training on day 56 of training, than the NC group. The TST group showed significantly lower theoretical Pcrit values on days 28 and 56 of training than the NC group (-4.07±0.92 vs -3.12±0.77 cmH2O, P< 0.05, -4.66±0.74 vs -3.07±0.38 cmH2O, P< 0.01). Conclusion: This study revealed that an 8-week TST could gradually and transiently increase corticomotor excitability of genioglossus, elevate the genioglossus EMG activity, and ultimately enhance the stability of the upper airway during daytime. Moreover, improved neuromuscular excitability occurred prior to the enhanced upper airway stability. These findings provide a theoretical foundation for TST as a promising treatment for OSA patients.
Technology Adaption As Survival Strategy For Small And Medium Enterprises During COVID-19

Globally, business and operational capabilities of Small and Medium Enterprises (SMEs) have been enormously affected by the Covid-19 pandemic, forcing many to use technology and innovation rather than the more traditional methods of operations. Although we do not yet know to the extent to which Oman’s SMEs have adopted these technological transformations, we investigate this, and assess the impact of it, in this study. We empirically examine how Covid-19 accelerated technology use in the SMEs in Oman and test nine hypotheses applying paired t-test and Pearson correlation. The results show strong correlations between technology use before and during Covid-19 (r = .823, p < 0.01); technology use during Covid-19 and in future (r = .659, p < 0.01); and technology use before Covid-19 and in future (r = .612, p < 0.01). We conclude that this use of technology has been a survival strategy during the pandemic and that highly digitized SMEs are more likely to adopt Industry 4.0 technology.
P-Glycoprotein Activity at Diagnosis Does Not Predict Therapy Outcome and Survival in Canine B-Cell Lymphoma

Simple Summary Clinical experience in human and canine clinics shows that following initial response to treatment, drug-resistant cancer cells frequently evolve and eventually, most tumors become resistant to all available therapies. The most straightforward cause of therapy resistance is linked to cellular alterations that prevent drugs from acting on their target. Drug efflux mediated by the ABC transporter P-glycoprotein (P-gp) contributes to unfavorable treatment outcome in several human malignancies. Here, we characterize a large cohort of canine B-cell lymphoma patients followed for over 7 years. We show that the intrinsic P-gp activity of tumor cells characterized at the time of diagnosis is not predictive for therapy outcome. Our results highlight the complexity of clinical drug resistance mechanisms and suggests that the relevance of P-gp in acquired resistance should be further investigated by the continuous monitoring of tumor cells during treatment. Abstract Various mechanisms are known to be involved in the development of multidrug resistance during cancer treatment. P-glycoprotein (P-gp) decreases the intracellular concentrations of cytotoxic drugs by an energy-dependent efflux mechanism. The aim of this study was to investigate the predictive value of P-gp function based on the evaluation of P-gp activity in tumor cells obtained from canine B-cell lymphoma patients at diagnosis. P-gp function of 79 immunophenotyped canine lymphoma samples was determined by flow cytometry using the Calcein assay. Dogs were treated with either the CHOP or the L-CHOP protocol, a subset of relapsed patients received L-asparaginase and lomustine rescue treatments. Among the 79 dogs, the median overall survival time was 417 days, and the median relapse-free period was 301 days. 47 percent of the samples showed high P-gp activity, which was significantly higher in Stage IV cancer patients compared to Stage II + III and V. Whereas staging was associated with major differences in survival times, we found that the intrinsic P-gp activity of tumor cells measured at diagnosis is not predictive for therapy outcome. Further studies are needed to identify the intrinsic and acquired resistant mechanisms that shape therapy response and survival in B-cell canine lymphoma patients.
The predictive diagnosis for ANGPTL8 level in women with T2DM

Background: The metabolic syndrome including type 2 diabetes mellitus(T2DM), insulin resistance(IR), obese, hypertension, and dyslipidemia, is an increasing health burden. In the last decade, various metabolic hormones have been noticed to significantly role obese and associated complications. for example of this, the adipokines or hepatokines secreted proteins from hepatocyte and adipocyteare correlate with metabolic syndrome. Angiopoietin-like protein 8 (ANGPTL8) has a novel hepatokine or adipokine, which is mostly expressed in the adipose tissue, and liver stimulates the β-cell proliferation as a pancreatic in an insulin resistance state. It's a recently discovered the endocrine regulator associated with glucose homeostasis, IR, and metabolism of lipid. Materials and Methods: Ninety women participated in this study, comprising sixty patients with diabetes mellitus type-2 and thirty healthy (sex and age - matched) as a control group. Enzyme linked immune sorbent assay (ELISA) was used to assess ANGPTL8 and insulin. Standard procedures were used to measure fasting blood glucose, lipid profile, and glycated hemoglobin (HBA1c) in a certified laboratory. Results: Diabetes patients had higher levels of ANGPTL8 than the control group. The blood ANGPTL8 level in the Type-2 diabetes group varied from 4432.89±1171.09 pg/ml, while the control group's level was 2892.11±537.91pg/dl (p<0.0001).
Are Crohn’s Disease Patients Limited in Sport Practise? An UltraEndurance Case–Control Study Response

The aim of this study was to analyze the psychophysiological response of a Crohn’s Disease patient in an ultra-endurance event. The psychophysiological responses of a Crohn’s Disease and non-Crohn’s Disease participant were analysed before during and after an 8 h ultra-endurance running event. Results showed how Crohn’s patient presented a similar psychophysiological response than non-Crohn’s participant in the ultra-endurance event, except for a higher pre- and post-event sympathetic modulation, lower event sympathetic tone, and lower event body temperature. This study could contribute to improving physical activity recommendations for persons with Crohn’s Disease and open a new research line for an improved understanding of psychophysiological modifications of Crohn’s Disease patients during exercise.
Smile InTM Totems in Radiotherapy: Patients’ Satisfaction with Limited Equipment and COVID-19

Background: We report a mono-institutional experience regarding patient-perceived quality regarding the Chieti Radiotherapy Department, through RAMSI (Radiotherapy Amica Mia—SmileINTM(SI)—My Friend RadiotherapySI) project, in critical scenarios of limited equipment and COVID-19. Material and methods: Patient-reported experience measures (PREMs) were assessed as follows: Patient-centric welcome perception (PCWP), Comfort, Professional skills and Punctuality. Patients could give anonymous feedback using HappyOrNot technology through four totems located in strategic areas within the center. An internal benchmark was obtained using the feedback received after a preliminary observation period. The SI Experience Index was collected, analyzed and compared. Weekly and monthly reports were generated. Results: From February 2019 to February 2022, 8924 patients accessed the department; 17,464 daily treatments were recorded and 5830 points of feedback were collected: 896, 1267, 1125 and 2542 for PCWP, Comfort, Professional skills and Punctuality, respectively. A LINAC decommissioning period was analyzed, with decreases in the SI-Index score and Smile-IN approved percentage and an improvement after this period. Additionally, the COVID-19 pandemic was analyzed with a mild evaluations decrease for PREM’s Welcome, Comfort and Punctuality (Δ-value: −9%, −3% and −4%, respectively), while Professional skills were always optimal. Conclusion: The RAMSI project was effective for assessing treatment quality perception, allowing for improving clinical procedures with corrective actions. The RAMSI project is ongoing.
Improving and Predicting the Effectiveness of Dispersed, Multi-Disciplinary Design Teams

Improving and Predicting the Effectiveness of Dispersed, Multidisciplinary Design Teams Matthew Oliver Wald Department of Mechanical Engineering, BYU Master of Science The use of dispersed (virtual) teams is growing rapidly in the engineering profession. To help prepare students for work in this type of industry, university engineering courses are requiring students to work in teams. Industry leaders and university faculty are interested in improving and measuring the performance of these distributed teams. Surveys, interviews, and observations from the AerosPACE Partners for the Advancement of Collaborative Engineering (AerosPACE) capstone design course are examined to demonstrate how different collaboration tools can be used to best enhance a distributed design team’s effectiveness. Collaboration tools to which distributed design teams should give extra consideration at different stages of the product development process are identified and presented in a model. Teams that follow this model will be more effective in their communication patterns. This study also consists of examining whether peer ratings can accurately predict team effectiveness (as defined by task and relational effectiveness) within a dispersed multidisciplinary, design team. The hypotheses predict that peer ratings will not be unidimensional over time, and will have a positive, significant relationship with team effectiveness. A longitudinal study was conducted on data gathered form the same capstone design course. Confirmatory factor analysis (CFA) was first used to test unidimensionality of peer ratings and structural equation modeling (SEM) was used to model the data and determine any predictive relationships. Model fit statistics are reported to confirm adequate fit for each model. Results showed that while peer ratings are unidimensional at individual time points, they don’t behave equally over time and should be considered separately. The structural equation models yielded mixed results, with some parts of peer ratings significantly predicting relational effectiveness and with yet failing to predict task effectiveness. As such, by examining peer assessments, supervisors and faculty will be able to determine and predict relational effectiveness of teams working at different locations, but should use other methods to predict task effectiveness.
Readiness of The Community-Based Organization in Improving Female Adolescents Iron Folate Status in a Rural Area

The iron deficiency anemia status of female adolescents needs attention because of its increasing prevalence and impact on adolescent health today and in the future, as well as the country's socio-economic status. Efforts to reduce cases of anemia in female adolescents need to involve multisectoral organizations, including community-based organizations (CBO). Karang-taruna and Posyandu cadres, as CBOs form in rural areas, have the potential to be involved in collaborative programs to improve the anemia status of female adolescents in rural areas. This study aims to identify CBO's readiness to prevent and control anemia in adolescent girls in Sirnagalih village, Bogor, West Java. This study uses a cross-sectional design with a mixed-method approach. The subjects of this study consisted of key resource persons consisting of a village head, three village officers, a head of Karang-taruna, a health-center staff, 6 Karang-taruna members, and 10 Posyandu cadres. The selection of these subjects is based on their role in the village as key persons who willingly participate. The results showed that most CBO members had less knowledge of female adolescents' anemia prevention programs (43.75%). But have a good attitude (56.25%) and self-efficacy (68.75%). The readiness of CBO at Sirnagalih village was at the first level, meaning that CBO members are not aware of the problem of anemia in young women in rural areas. It is necessary to make intervention efforts to increase the readiness of CBOs before further collaborative efforts are carried out.
Evaluation of the Growth-Inhibitory Spectrum of Three Types of Cyanoacrylate Nanoparticles on Gram-Positive and Gram-Negative Bacteria

The development of novel effective antibacterial agents is crucial due to increasing antibiotic resistance in various bacteria. Poly (alkyl cyanoacrylate) nanoparticles (PACA-NPs) are promising novel antibacterial agents as they have shown antibacterial activity against several Gram-positive and Gram-negative bacteria. However, the antibacterial mechanism remains unclear. Here, we compared the antibacterial efficacy of ethyl cyanoacrylate nanoparticles (ECA-NPs), isobutyl cyanoacrylate NPs (iBCA-NPs), and ethoxyethyl cyanoacrylate NPs (EECA-NPs) using five Gram-positive and five Gram-negative bacteria. Among these resin nanoparticles, ECA-NPs showed the highest growth inhibitory effect against all the examined bacterial species, and this effect was higher against Gram-positive bacteria than Gram-negative. While iBCA-NP could inhibit the cell growth only in two Gram-positive bacteria, i.e., Bacillus subtilis and Staphylococcus aureus, it had negligible inhibitory effect against all five Gram-negative bacteria examined. Irrespective of the differences in growth inhibition induced by these three NPs, N-acetyl-L-cysteine (NAC), a well-known reactive oxygen species (ROS) scavenger, efficiently restored growth in all the bacterial strains to that similar to untreated cells. This strongly suggests that the exposure to NPs generates ROS, which mainly induces cell growth inhibition irrespective of the difference in bacterial species and cyanoacrylate NPs used.