Miracle-dz/UniFAR-FTUs huggingface dataset:
Narcissism and Self-Esteem Revisited : The Mediating Roles of Perceived Status and Inclusion

ABSTRACT The purpose of the present study was to examine whether narcissistic personality features had indirect associations with state self-esteem through perceived status and inclusion. We used a daily diary approach to examine whether daily perceptions of status and inclusion mediated the associations that narcissistic admiration (an agentic form of narcissism that is characterized by assertive self-enhancement and self-promotion) and narcissistic rivalry (an antagonistic form of narcissism that is characterized by self-protection and self-defense) had with daily reports of state self-esteem in 808 undergraduate students. Narcissistic admiration had positive indirect associations with state self-esteem through perceived status and inclusion, whereas narcissistic rivalry had negative indirect associations with state self-esteem through perceived status and inclusion. These results suggest that perceptions of status and inclusion may contribute to the feelings of self-worth that are experienced by individuals with narcissistic personality features. Discussion focuses on the implications of these results for our understanding of the connections between narcissism and self-esteem.
Pathological Analysis of Encased Resected Recurrent Nerves in Locally Invasive Thyroid Cancer

Simple Summary Thyroid cancer encasing the recurrent nerve is rare, and the decision to resect or preserve the nerve is multifactorial. The aim of this retrospective study was to evaluate the rate of actual invasion of the nerve beyond the nerve sheath in cancers encasing the nerve. Fifty-two patients were included: 7 cases of medullary thyroid carcinoma, 8 papillary thyroid carcinomas in children and 37 follicular derived cancers in adults. Tumor-related vocal fold paralysis was present in 30% of cases. The nerve was invaded in 82% of follicular cell-derived tumors, 88% of pediatric cases, and 100% of medullary carcinomas. Only agressive histology was a risk factor for nerve invasion. Vocal fold paralysis was not predictive. To our knowledge, this is one of the largest series with pathologic analysis of resected recurrent nerves, showing a high rate of nerve invasion in these rare cases of cancer encasing the reucrrent nerve. Abstract Objective: Thyroid cancer encasing the recurrent nerve is rare, and the decision to resect or preserve the nerve is multifactorial. The objective of this study was to histopathologically analyze resected encased nerves to assess the rate of nerve invasion and risk factors. Materials and Methods: A retrospective study was carried out on consecutive patients with resection of the recurrent nerve for primary or recurrent follicular cell-derived or medullary thyroid carcinoma from 2005 to 2020. Demographics, pathology, locoregional invasion, metastases, recurrences and survival were analyzed. Slides were reviewed blindly by two specialized pathologists (AAG, RC) for diagnosis of invasion deep to the epineurium. Results: Fifty-two patients were included: 25 females; average age, 55 (range 8–87). In total, 87% percent (45/52) were follicular cell-derived with 17/45 (37.8%) aggressive variants; 13% (7/52) were medullary carcinoma. Preoperative vocal fold (VF) paralysis was present in 16/52 (30.7%). Pathologically, the nerve was invaded in 44/52 cases (85%): 82% of follicular cell-derived tumors (37/45), 88% of pediatric cases, and 100% of medullary carcinomas (7/7). Nerve invasion was observed in 11/16 (69%) with preoperative VF paralysis and 33/36 (92%) with normal VF function. Only aggressive histology was correlated with nerve invasion in follicular cell-derived tumors (p = 0.019). Conclusions: The encased nerves were pathologically invaded in 82% of follicular cell-derived tumors and in 100% of medullary carcinomas. Nerve invasion was statistically correlated with aggressive histopathological subtypes and was observed in the absence of VF paralysis in 92% of cases.
Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient

Advances in our understanding of the biology of spinal systems in organizing and defining the content of exteroceptive information upon which higher centers define the state of the organism and its role in the regulation of somatic and automatic output, defining the motor response of the organism, along with the unique biology and spatial organization of this space, have resulted in an increased focus on therapeutics targeted at this extracranial neuraxial space. Intrathecal (IT) drug delivery systems (IDDS) are well-established as an effective therapeutic approach to patients with chronic non-malignant or malignant pain and as a tool for management of patients with severe spasticity and to deliver therapeutics that address a myriad of spinal pathologies. The risk to benefit ratio of IDD makes it a useful interventional approach. While not without risks, this approach has a significant therapeutic safety margin when employed using drugs with a validated safety profile and by skilled practioners. The present review addresses current advances in our understanding of the biology and dynamics of the intrathecal space, therapeutic platforms, novel therapeutics, delivery technology, issues of safety and rational implementation of its therapy, with a particular emphasis upon the management of pain.
Research on flow-sound separation algorithm of aerodynamic noise based on immersed boundary method

With the development of theoretical models, numerical algorithms and available computational power, numerical aero-acoustics presents a huge prospect for solving the actual problems of aerodynamic noises. Under low Mach number, structures with a complicated geometric shapes were selected as the research objects to analyze their aerodynamic noises by means of flow-sound separation algorithm based on immersed boundary method. Firstly, the incompressible complicated flow field was solved on the basis of immersed boundary method, and the flow field parameters were obtained as the input values. Then, the linear compressible perturbation equation was solved to simulate generation and travel of acoustic waves. This method was used to predict the noise of flow past two circular cylinders in tandem arrangements and the aerodynamic noise of the rudimentary landing gear. The numerical simulation was then compared with the corresponding experiments, and results were consistent. That showed the algorithm proposed was feasible.
An Infinite-Norm Algorithm for Joystick Kinematic Control of Two-Wheeled Vehicles

In this paper, we propose an algorithm based on the mathematical p-norm which has been applied to improve both the traction power and the trajectory smoothness of joystick-controlled two-wheeled vehicles. This algorithm can theoretically supply 100% of available power to each of the actuators if the infinity-norm is used, i.e., when the p-norm tends to infinity. Furthermore, a geometrical model using the radius of curvature has been developed to track the effect of the proposed algorithm on the vehicle’s trajectory. Findings in this research work contribute to the kinematic control and path planning algorithms for vehicles actuated by two wheels, such as tanks and electric wheelchairs, both of vital importance for the security and heath industry. Computer simulations and experiments with a real robot are performed to verify the results.
A fluid injection.

The invention relates to an injector (7) having an injection axis (AB) and comprising: - a housing (2) comprising a cavity (20) axially, - an actuator (3) comprising an electro-active portion (30) and having o a first end face (31) extended by a penetrating member (33), and o a second end face (32) opposite the first (31), the actuator (3) being mounted in the housing (2) and the member (33) comprising a piston (330) engaged in the cavity (20) and forming a fluid connection between the actuator (3) and the housing (2), - excitation means for put the electro-portion (30) of the actuator (3) in vibration with a setpoint period t, According to the invention, the penetrating member (33) has a length (L) as the propagation time T wave the acoustic browsing satisfies the equation: T = [2n + 1] * [t / 4], where n is a multiplier, positive integer.
Automatic Artifact Detection Algorithm in Fetal MRI

Fetal MR imaging is subject to artifacts including motion, chemical shift, and radiofrequency artifacts. Currently, such artifacts are detected by the MRI operator, a process which is subjective, time consuming, and prone to errors. We propose a novel algorithm, RISE-Net, that can consistently, automatically, and objectively detect artifacts in 3D fetal MRI. It makes use of a CNN ensemble approach where the first CNN aims to identify and classify any artifacts in the image, and the second CNN uses regression to determine the severity of the detected artifacts. The main mechanism in RISE-Net is the stacked Residual, Inception, Squeeze and Excitation (RISE) blocks. This classification network achieved an accuracy of 90.34% and a F1 score of 90.39% and outperformed other state-of-the-art architectures, such as VGG-16, Inception, ResNet-50, ReNet-Inception, SE-ResNet, and SE-Inception. The severity regression network had an MSE of 0.083 across all classes. The presented algorithm facilitates rapid and accurate fetal MRI quality assurance that can be implemented into clinical use.
Culturally-Responsive Relational Practice at the Chalk-Face: A journey to Authenticity

This research provides chalk-face insights from a group of predominantly Pakeha teachers grappling with culturally-responsive relational practice (CRRP), in a time and environment where external factors can affect self-efficacy and limit personal agency. Itdetails a two-phased professional inquiry undertaken with fourteen teachers from one Ka hui Ako, whereby themes from a larger cross-school online survey were unpacked through a series of semi-structured focus groups. In every phase of this research, including this final telling, the emphasis was on foregrounding the stories of teachers. Findings critique taken-for-granted assumptions about teachers’ roles and responsibilities for embedding CRRP, and stress that in our efforts to stop deficising students, we do not unintentionally deficise teachers.
TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination

In the fight against prostate cancer (PCa), TRPM8 is one of the most promising clinical targets. Indeed, several studies have highlighted that TRPM8 involvement is key in PCa progression because of its impact on cell proliferation, viability, and migration. However, data from the literature are somewhat contradictory regarding the precise role of TRPM8 in prostatic carcinogenesis and are mostly based on in vitro studies. The purpose of this study was to clarify the role played by TRPM8 in PCa progression. We used a prostate orthotopic xenograft mouse model to show that TRPM8 overexpression dramatically limited tumor growth and metastasis dissemination in vivo. Mechanistically, our in vitro data revealed that TRPM8 inhibited tumor growth by affecting the cell proliferation and clonogenic properties of PCa cells. Moreover, TRPM8 impacted metastatic dissemination mainly by impairing cytoskeleton dynamics and focal adhesion formation through the inhibition of the Cdc42, Rac1, ERK, and FAK pathways. Lastly, we proved the in vivo efficiency of a new tool based on lipid nanocapsules containing WS12 in limiting the TRPM8–positive cells’ dissemination at metastatic sites. Our work strongly supports the protective role of TRPM8 on PCa progression, providing new insights into the potential application of TRPM8 as a therapeutic target in PCa treatment.
A Two-Stage SEM—Artificial Neural Network Analysis of the Engagement Impact on Employees’ Well-Being

Employees’ engagement (EE) and well-being (WB) are considered two interesting issues by many scientific researchers and practitioners within organizations. Most research confirms a positive correlation between EE and WB. EE is an essential premise for specific dimensions of employees’ WB. At the same time, satisfied and physically and mentally healthy employees increase EE, both EE and WB thus being fundamental to individual and organizational performance. This paper aims to evaluate the relationships between EE and WB and between the dimensions of these two complex constructs. These relationships were assessed based on data obtained from a sample of 269 employees in Romania, using as a method a mix of analyses based on structural equation modeling (SEM) and artificial neural network analysis (ANN). The results highlighted a positive two-way relationship between EE and WB. Among the dimensions of EE, motivation and work environment are those that ensure a more pronounced perception of WB by the employee. Emotional WB, occupational WB, and social WB are the dimensions of WB with a significant influence on the general level of EE.
Adaptive fractional-order PID control of PMSG-based wind energy conversion system for MPPT using linear observers

This paper designs a novel adaptive fractional-order PID (AFOPID) control of a permanent magnetic synchronous generator (PMSG) based wind energy conversion system (WECS), which attempts to extract the maximum wind power by using a linear perturbation observer. The combinatorial effect of generator nonlinearities and parameter uncertainties, unmodelled dynamics, stochastic wind speed variation is aggregated into a perturbation, which is then estimated in the real-time by a linear extended-state observer (ESO) called high-gain state and perturbation observer (HGSPO). Besides, the perturbation estimate is employed as an auxiliary control signal which is fully compensated by a fractional-order PID (FOPID) controller to achieve a globally robust control consistency, simple structure and high reliability, as well as an improved tracking performance compared to that of PID control. In addition, AFOPID does not require an accurate PMSG model while only the measurement of d-axis current and mechanical rotation speed is required, which parameter is optimally tuned by particle swarm optimization (PSO). Four case studies are carried out, including step change of wind speed, low-turbulence stochastic wind speed, high-turbulence stochastic wind speed, and generator parameter uncertainties, respectively. Simulation results verify the effectiveness and superiority of AFOPID compared to that of PID, FOPID, and nonlinear control.
Psychological Support for Family Caregivers of Patients With Amyotrophic Lateral Sclerosis at the Time of the Coronavirus Disease 2019 Pandemic: A Pilot Study Using a Telemedicine Approach

The coronavirus disease 2019 (COVID-19) pandemic confined most of the population to homes worldwide, and then, a lot of amyotrophic lateral sclerosis (ALS) centers moved to telemedicine services to continue to assist both patients with ALS and their caregivers. This pilot, randomized, controlled study aimed to explore the potential role of psychological support interventions for family caregivers of patients with ALS through resilience-oriented sessions of group therapy during the COVID-19 pandemic. In total, 12 caregivers agreed to be remotely monitored by our center since March 2020 and underwent scales for global burden (i.e., Caregiver Burden Inventory, CBI), resilience (i.e., Connor Davidson Resilience Scale, CD-RISC), and perceived stress (i.e., Perceived Stress Scale, PSS) at two-time points (i.e., at pre-treatment assessment and after 9 months or at post-treatment assessment). They were randomized into two groups: the former group underwent resilience-oriented sessions of group therapy two times a month for 3 months, while the latter one was only remotely monitored. No significant differences were found in CBI, CD-RISC, and PSS during the 9-month observation period in the treated group compared with the control group, suggesting a trend toward stability of caregiver burden together with resilience and perceived stress scores in all the subjects monitored. The lack of differences in caregivers’ burden, resilience, and perceived stress scores by comparing the two groups monitored during 9 months could be due to the co-occurrence of the COVID-19 pandemic with the stressful events related to caring for patients with ALS that might have hindered the detection of significant benefits from short-lasting psychological support.
Tailored Polyelectrolyte Multilayer Systems by Variation of Polyelectrolyte Composition and EDC/NHS Cross-Linking: Physicochemical Characterization and In Vitro Evaluation

The layer-by-layer (LbL) self-assembly technique is an effective method to immobilize components of the extracellular matrix (ECM) such as collagen and heparin onto, e.g., implant surfaces/medical devices with the aim of forming polyelectrolyte multilayers (PEMs). Increasing evidence even suggests that cross-linking influences the physicochemical character of PEM films since mechanical cues inherent to the substrate may be as important as its chemical nature to influence the cellular behavior. In this study, for the first-time different collagen/heparin films have been prepared and cross-linked with EDC/NHS chemistry. Quartz crystal microbalance, zeta potential analyzer, diffuse reflectance Fourier transform infrared spectroscopy, atomic force microscopy and ellipsometry were used to characterize film growth, stiffness, and topography of different film systems. The analysis of all data proves a nearly linear film growth for all PEM systems, the efficacy of cross-linking and the corresponding changes in the film rigidity after cross-linking and an appropriate surface topography. Furthermore, preliminary cell culture experiments illustrated those cellular processes correlate roughly with the quantity of newly created covalent amide bonds. This allows a precise adjustment of the physicochemical properties of the selected film architecture regarding the desired application and target cells. It could be shown that collagen improves the biocompatibility of heparin containing PEMs and due to their ECM-analogue nature both molecules are ideal candidates intended to be used for any biomedical application with a certain preference to improve the performance of bone implants or bone augmentation strategies.
Walkability: Which Measure to Choose, Where to Measure It, and How?

The urban structure of neighborhoods has a decisive impact on active mobility, but this impact is hard to evaluate in a mode choice model because of the high collinearity between urban form variables and the uncertainty surrounding adequate spatial measurement parameters. Several composite scores, or walkability measures, have emerged from the literature, each using its own method and including different variables. No consensus has been reached on the size of the catchment area that should be used to measure walkability and most studies only measure walkability at the origin of the trip without considering other spatial units. In this paper, a series of four walkability measures: the Pedestrian Index of the Environment (PIE), the Walkability Index (WI), the Pedestrian Potential Index (PPI) and the Neighborhood Destination Accessibility Index (NDAI), are applied to the Greater Montréal Area to examine their correlation with the choice of walking for short trips. Several definitions of a neighborhood are tested for each measure, as well as several spatial units of measurement. A series of binary logistic regressions are then estimated using observed trip data from the 2013 Montreal Origin–Destination Survey to identify which measure, using which spatial parameters, offers the best performance in a mode choice modeling context. Measures using a diversity of urban form variables, the WI and the PIE, are found to offer the best performance, especially when measured at a scale smaller than a 1.6 km radius, while the spatial unit offering the best model fit varies between trip purposes.
Longitudinal Changes in Circulating Metabolites and Lipoproteins After Breast Cancer Treatment

The multimodal treatment of breast cancer may induce long term effects on the metabolic profile and increase the risk of future cardiovascular disease. In this study, we characterized longitudinal changes in serum lipoprotein subfractions and metabolites after breast cancer treatment, aiming to determine the long-term effect of different treatment modalities. Further, we investigated the prognostic value of treatment-induced changes in breast cancer-specific and overall 10-year survival. In this study, serum samples from breast cancer patients (n = 250) were collected repeatedly before and after radiotherapy, and serum metabolites and lipoprotein subfractions were quantified by NMR spectroscopy. Longitudinal changes were assessed by univariate and multivariate data analysis methods applicable for repeated measures. Distinct changes were detectable in levels of lipoprotein subfractions and circulating metabolites during the first year, with similar changes despite large differences in treatment regimens. We detect increased free cholesterol and decreased esterified cholesterol levels of HDL subfractions, a switch towards larger LDL particles and higher total LDL-cholesterol, in addition to a switch in the glutamine-glutamate ratio. Non-survivors had different lipid profiles from survivors already at baseline. To conclude, our results show development towards an atherogenic lipid profile in breast cancer patients with different treatment regimens.
Programmed Cell Death Protein 1/Programmed Cell Death Protein Ligand 1 Immunosuppressants in Advanced Non-Small Cell Lung Cancer Research Progress in Treatment

PD-1/PD-L1 play key roles in tumor immune escape and the formation of the tumor microenvironment, and are closely related to the generation and development of tumors. Blocking the PD-1/PD-L1 pathway can reshape the tumor microenvironment or block the formation of the tumor microenvironment and enhance endogenous antitumor immune response. Clinical trials show that the treatment of non-small cell lung cancer (NSCLC) with PD-1/PD-L1 inhibitors has significant advantages. The review briefly describes these basic principles of the PD-1/PD-L1 pathway and action mechanism in the treatment of NSCLC. A summary of global PD-1/PD-L1 clinical trials and five PD-1/PD-L1 inhibitors approved by FDA, EMA and NMPA for advanced NSCLC were analyzed.
Evaluating Strategies To Collect Micrometeorites From Rainwater For Citizen Scientists

Micrometeorites originate from small pieces of rock from space colliding with the Earth’s atmosphere at high velocity, such as the Perseid meteors which hit the atmosphere at 60 km/s. When they do so, they burn up, causing a flash of light that we see as a meteor. Many groups have been successful collecting these particles using various devices. Such activities make great science projects for middle and high school students, and we plan to start a program to train students in the collecting methods and get them interested in science, technology, engineering and math (STEM) careers. Various methods are used to collect micrometeorites from rainwater, but little work has been done to assess the most efficient method of collecting these particles from space and then analyzing them. Before we began our citizen science project, we determined that it was necessary to conduct a pilot project to determine the most effective method of collecting micrometeorites from rainwater. Four collecting methods were tried and the method that collected the most micrometeorites was also the simplest, that being a simple bucket under the downspout of the gutter system of a house and a magnet which is then run through the bucket to gather the meteorites.