Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of CYP450 Enzymes and ABCB1 Polymorphisms on Clopidogrel Response in Moroccan Patients with Acute Coronary Syndromes

Introduction Clopidogrel is an antiplatelet prodrug primarily prescribed to prevent or treat acute coronary syndrome (ACS) or acute ischemic stroke (IS), polymorphisms of genes encoding cytochrome P-450 (CYP) and P-glycoprotein transporter, could affect the efficiency of clopidogrel absorption and biotransformation, especially during the first critical hours following its administration. Methods The present study was designed to investigate the potential association of clopidogrel responsiveness and 14 polymorphisms in the genes encoding the CYPs (CYP2C9, 2C19, 3A4, 3A5, 1A2, and 2B6), the ATP binding cassette subfamily B member 1 (ABCB1). Platelet aggregation activity was measured after 8h of 300mg clopidogrel administration for fifty-five ACS patients. Results There was no significant association between polymorphism of the studied CYPs and clopidogrel responsiveness (P>0.05). The frequency of the ABCB1 3435 T allele in clopidogrel non-responders was higher (78.9%) compared to responders (52.8%), but this difference was not significant (P=0.057). Demographic characteristics, comorbidities, concomitant treatments were not associated with clopidogrel response. Discussion There was no effect of the studied genetic variations and demographic factors on the platelet activity of clopidogrel in Moroccan ACS patients.
Millimeter-Wave, High-Gain, Dielectric Resonator One-Dimensional Leaky-Wave Antenna

A millimeter-wave (MMW) one-dimensional leaky-wave antenna (1-D LWA) with high gain is proposed. By using a dielectric resonator (DR) operating on its higher-order transverse electric mode (TE113) as a radiating element of a substrate integrated waveguide, the gain and radiation efficiency of the 1-D LWA can be improved. Meanwhile, the open stopband is suppressed through a tilted slot coupling method, achieving broadside direction at 35 GHz. Finally, a prototype was produced and measured. It has the measured maximum gain of 17.03 dBi and radiation efficiency of 90% at 39 GHz. The measured results demonstrate that the 1-D LWA can continuously scan from −61° to 20° within a 38.8% impedance bandwidth.
Optimizing Employee Performance through Timeliness in the Department of Population and Civil Registration of Bone Regency

This study focuses on the performance of employees in the Bone Regency Population and Civil Registration Service, with a specific emphasis on timeliness in completing work tasks. The aim is to analyze and evaluate employee performance in this dimension. The study contributes to the understanding of performance measurements in organizational settings and offers practical insights to enhance employee performance and meet public expectations in population and civil registration services. Using a descriptive research methodology with a qualitative approach, the study involved interviews, observations, and document analysis for data collection. The main findings reveal that employee performance in the timeliness dimension at the Bone Regency Population and Civil Registration Service is suboptimal. Factors contributing to this include the complexity of document processing, inadequate technological support, and poor time management. This study fills a gap in the literature by addressing specific challenges related to timeliness in employee performance within population and civil registration services. It provides recommendations for improvement, such as offering training on efficient document management, utilizing relevant technology, providing adequate support facilities, and enhancing coordination and communication. Implementing these corrective measures can help enhance employee performance in the service and improve overall efficiency. Keywords: employee performance, public service, effectiveness
Sediment entrainment probability and threshold of sediment suspension: exponential-based approach

AbstractThis study examines the probability for sediment entrainment to bed load and the probability for the threshold condition of sediment to be in suspension. The theoretical analysis is based on a simple one-sided exponential distribution of probability function. The probability distributions are derived from a truncated universal Gram-Charlier series expansion based on the exponential or Laplace-type distributions for turbulent velocity fluctuations. The key criterion of sediment entrainment is the hydrodynamic lift acting on a solitary particle to exceed submerged weight of the particle. In this way, a simple probability function for sediment entrainment to bed load in terms of Shields parameter containing the lift coefficient is obtained. It was found that the value of lift coefficient as 0.15 satisfactorily fitted the probability function versus Shields parameter curve with the experimental data. On the other hand, the key criterion of the threshold of sediment suspension is the fluctuations of th.
The Heilongjiang Group: A Jurassic accretionary complex in the Jiamusi Massif at the western Pacific margin of northeastern China

Abstract The tectonic setting of the Eastern Asian continental margin in the Jurassic is highly controversial. In the current study, we have selected the Heilongjiang complex located at the western margin of the Jiamusi Massif in northeastern China for geochronological investigation to address this issue. Field and petrographic investigations indicate that the Heilongjiang complex is composed predominately of granitic gneiss, marble, mafic‐ultramafic rocks, blueschist, greenschist, quartzite, muscovite‐albite schist and two‐mica schist that were tectonically interleaved, indicating they represent a mélange. The marble, two‐mica schist and granitic gneiss were most probably derived from the Mashan complex, a high‐grade gneiss complex in the Jiamusi Massif with which the Heilongjiang Group is intimately associated. The ultramafic rocks, blueschist, greenschist and quartzite (chert) are similar to components in ophiolite. The sensitive high mass‐resolution ion microprobe U‐Pb zircon age of 265 ± 4 Ma for the granitic gneiss indicates that the protolith granite was emplaced coevally with Permian batholiths in the Jiamusi Massif. 40Ar/39Ar dating of biotite and phengite from the granitic gneiss and mica schist yields a late Early Jurassic metamorphic age between 184 and 174 Ma. Early components of the Jiamusi Massif, including the Mashan complex, probably formed part of an exotic block from Gondwana, affected by late Pan‐African orogenesis, and collided with the Asian continental margin during the Early Jurassic. Subduction of oceanic crust between the Jiamusi block and the eastern part of the Central Asian Orogenic Belt resulted in the formation of a huge volume of Jurassic granites in the Zhangguangcai Range. Consequently, the collision of the Jiamusi Massif with the Central Asian Orogenic Belt to the west can be considered as the result of circum‐Pacific accretion, unrelated to the Central Asian Orogenic Belt. The widespread development of Jurassic accretionary complexes along the Asian continental margin supports such an interpretation.
Estimated net community production during the summertime at the SEATS time‐series study site, northern South China Sea: Implications for nitrogen fixation

The continuous summertime drawdown of normalized dissolved inorganic carbon has been observed repeatedly in the mixed‐layer at the South East Asia Time‐series Study (SEATS) site, northern South China Sea (SCS) between March 2002 and November 2004. Mass balance calculation reveals that a net community production (NCP) of −4.47 mmolC m−2 day−1 is responsible for this drawdown. Nonetheless, bioavailable nitrogen (Nbio) from atmospheric deposition, vertical diffusion, and N2‐fixation by Trichodesmium and Richelia together could only account for ∼55% of Nbio required for the calculated NCP. Unicellular cyanobacteria, which are identified unambiguously by the presence of nitrogenase genes (nifH) in 1–10 μm fraction of planktons collected at SEATS, may account for the Nbio deficit. Our results, thus, support the potential importance of unicellular cyanobacteria in providing an additional Nbio source in oligotrophic waters such as the SCS.
Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABAA receptors, in a mouse model of Dravet syndrome

Introduction: Dravet syndrome (DS) is an intractable epilepsy syndrome concomitant with neurodevelopmental disorder that begins in infancy. DS is dominantly caused by mutations in the SCN1A gene, which encodes the α subunit of a voltage-gated Na channel. Pre-synaptic inhibitory dysfunction is regarded as the pathophysiological mechanism, but an effective strategy for ameliorating seizures and behavioral problems is still under development. Here, we evaluated the effects of KRM-II-81, a newly developed positive allosteric modulator for α 2/3 subunit containing GABAA receptors (α2/3-GABAAR) in a mice model of DS both in vivo and at the neuronal level. Methods: We used knock-in mice carrying a heterozygous, clinically relevant SCN1A mutation (background strain: C57BL/6 J) as a model of the DS (Scn1a WT/A1783V mice), knock-in mouse strain carrying a heterozygous, clinically relevant SCN1A mutation (A1783V). Seizure threshold and locomotor activity was evaluated by using the hyperthermia-induced seizure paradigm and open filed test, respectively. Anxiety-like behavior was assessed by avoidance of the center region in locomotor activity. We estimated a sedative effect by the total distance traveled in locomotor activity and grip strength. Inhibitory post synaptic currents (IPSCs) were recorded from a hippocampal CA1 pyramidal neuron in an acutely prepared brain slice. Results: KRM-II-81 significantly increased the seizure threshold of Scn1a WT/A1783V mice in a dose-dependent manner. A low dose of KRM-II-81 specifically improved anxiety-like behavior of Scn1a WT/A1783V mice. A sedative effect was induced by relatively high dose of KRM-II-81 in Scn1a WT/A1783V mice, the dose of which was not sedative for WT mice. KRM-II-81 potentiated IPSCs by increasing its decay time kinetics. This effect was more prominent in Scn1a WT/A1783V mice. Discussion: Higher activation of α2/3-GABAAR by KRM-II-81 suggests a compensatory modification of post synaptic inhibitory function against presynaptic inhibitory dysfunction in Scn1a WT/A1783V. The increased sensitivity for KRM-II-81 may be relevant to the distinct dose-dependent effect in each paradigm of Scn1a WT/A1783V mice. Conclusion: Selective activation for α2/3-GABAAR by KRM-II-81 could be potential therapeutic strategy for treating seizures and behavioral problems in DS.
The Level of Adherence to the ESPEN Guidelines for Energy and Protein Intake Prospectively Influences Weight Loss and Nutritional Status in Patients with Cancer

Nutrition therapy aims to prevent weight loss and its health consequences in patients with cancer. The aim of this study was to assess Greek patients’ adherence to the ESPEN guidelines for oncology patients and its prospective effect on their body weight (BW) and nutritional status. In total, 152 patients with cancer were recruited from the Attikon University Hospital, Greece, and provided data in 2019 (baseline) and 2020 (follow-up) (drop-out rate = 28.3%). Nutritional status was assessed with the PG-SGA questionnaire. Patients were categorized based on whether they adhered at least to the minimum ESPEN-recommended intakes of energy (≥25 kcal/kg/day) or protein (≥1.0 g/kg/day) or not. On average, patients did not adhere to ESPEN guidelines for energy and protein intake. Most patients meeting the minimum recommendations had an improvement of their nutritional status at follow-up and increased their BW compared to those not meeting them. All patients with head, neck, and spinal cancer who met the minimum recommendations for energy intake improved their nutritional status at follow-up. This study showed that consuming at least the minimum amounts of protein and energy recommended by ESPEN may prevent from weight loss and improve nutritional status; however, the exact amounts need to be personalized.
Depth-averaged open-channel flow model

A general mathematical model is developed to solve unsteady, depth-averaged equations. The model uses boundary-fitted coordinates, includes effective stresses, and may be used to analyze sub- and super critical flows. The time differencing is accomplished using a second-order accurate Beam and Warming approximation, while the spatial derivatives are approximated by second-order accurate central differencing. The equations are solved on a nonstaggered grid using an alternative-direction-implicit scheme. To enhance applicability, the equations are solved in transformed computational coordinates. The effective stresses are modeled by incorporating a constant eddy-viscosity turbulence model to approximate the turbulent Reynolds stresses. As is customary, the stresses due to depth-averaging are neglected. Excluding recirculating flows, it is observed that in most cases the effective stresses do not significantly affect the converged solution. The model is used to analyze a wide variety of hydraulics problems including flow in a channel with a hydraulic jump, flow in a channel contraction, flow near a spur-dike, flow in a 180° channel bend, and a dam-break simulation. For each of these cases, the computed results are compared with experimental data. The agreement between the computed and experimental results is satisfactory.
Telacebec Interferes with Virulence Lipid Biosynthesis Protein Expression and Sensitizes to Other Antibiotics

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a public health issue, particularly due to multi-drug-resistant Mtb. The bacillus is wrapped in a waxy envelope containing lipids acting as essential virulence factors, accounting for the natural antibiotic resistance of mycobacteria. Telacebec (previously known as Q203) is a promising new anti-TB agent inhibiting the cytochrome bc1 complex of a mycobacterial electron transport chain (ETC). Here, we show that the telacebec-challenged M. bovis BCG exhibited a reduced expression of proteins involved in the synthesis of phthiocerol dimycocerosates (PDIMs)/phenolic glycolipids (PGLs), lipid virulence factors associated with cell envelope impermeability. Consistently, telacebec, at concentrations lower than its MIC, downregulated the transcription of a PDIM/PGL-synthesizing operon, suggesting a metabolic vulnerability triggered by the drug. The drug was able to synergize on BCG with rifampicin or vancomycin, the latter being a drug exerting a marginal effect on PDIM-bearing bacilli. Telacebec at a concentration higher than its MIC had no detectable effect on cell wall PDIMs, as shown by TLC analysis, a finding potentially explained by the retaining of previously synthesized PDIMs due to the inhibition of growth. The study extends the potential of telacebec, demonstrating an effect on mycobacterial virulence lipids, allowing for the development of new anti-TB strategies.
Diet of wolverines (Gulo gulo) in the western Brooks Range, Alaska

Migratory caribou herds are an important component of the North American tundra. We investigated the wolverine (Gulo gulo) diet in the migratory range of the Western Arctic Caribou Herd in north-western Alaska. Within this area, caribou are absent or occur at low densities for large parts of the year, and thus show a strong seasonality in abundance. Analyses of stomach and colon contents suggested that wolverines primarily consumed caribou during the winter, and that the dietary dependence was related more to caribou mortality than to caribou abundance in the area. We also found indications that wolverines may switch between moose and caribou during periods of low caribou abundance, but that such a switch did not affect wolverine body condition. Our results thus support previous observations that wolverines primarily consume ungulates. However, a better knowledge of how alternative food sources are utilized will be necessary to predict the dietary and demographic responses of wolverines to variations in caribou abundance. We also suggest that further efforts should be made to investigate the effects of other ungulate-dependent predators on wolverine feeding ecology, because such predators may function both as competitors and as suppliers of carrion for scavenging.
Association of dietary patterns of pregnant women with pregnancy outcomes: A hospital‐based study

Abstract Diet is one of the main factors influencing pregnancy outcomes. Maternal and child health both seem to be related to dietary patterns. So far, no study on dietary pattern has been performed on pregnant women and its association with pregnancy outcomes in Rasht. Therefore, the present study aimed to investigate the association between dietary patterns and pregnancy outcomes in Rasht. In this cross‐sectional study, 300 healthy pregnant women were included from three public hospitals in Rasht. Data on demographic, dietary intake, physical activity (PA), and anthropometric measurements of mothers were recorded. Outcomes of newborns were also gathered. Dietary patterns were identified using principal component analysis. General linear model was used for data analysis. Prior to pregnancy, only 40% of women had a normal body mass index (BMI). More than half of them (52.3%) had a gestational weight gain in excess of the guidelines. The dominant dietary patterns among pregnant women were traditional, Western, and healthy, respectively. High adherence to the Western pattern had a direct association with gestational weight gain (B = 1.48, p = .046) and inverse association with birth length (B = −0.71, p = .043). However, the results did not remain significant after adjusting for covariates. The present study indicated that several factors can affect the association of the Western diet with pregnancy outcomes. Therefore, making policies for interventional programs to improve maternal lifestyle factors along with their diet quality is recommended.
Monitoring urban sprawl using simulated PROBA-V data

Urbanization proceeds currently at a rapid pace and the impact on natural ecosystems cannot be neglected. Consequently, it is important to be able to monitor the expansion of urban areas. Yet the process of extracting them from satellite imagery is not trivial. Urban is a non-uniform class with spectral proximity to barren land. In this article, a method for extracting urban areas from medium-resolution Earth observation data is presented. The information source is simulated data of the PROBA-V sensor. Visual and near-infrared bands are classified by the adaptive neuro-fuzzy inference system (ANFIS) neuro-fuzzy classifier into urban and non-urban classes. The method can overcome the main difficulty in similar efforts, i.e. the extensive commission errors of barren to the class urban. The main novelty relies on exploiting annual spectral variability of each land-use class at the pixel level. The basic assumption is that urban and barren areas may have similar spectral values but they have different phenological cycles. The overall accuracy obtained by the classification is 91.57% with a Cohen’s kappa coefficient (khat) of 0.84. Sufficient correlation at the city level is also achieved. Change detection is also possible in terms of hot-spot identification, however marginally suitable for medium-sized cities.
Healthy lifestyle counseling, and barriers perceived by general practitioners in Poland

Introduction The aim of the study was to determine the influence of the personal factors, such as body mass index (BMI), of general practitioners (GPs), and their counseling on weight management, healthy lifestyle, and their perceived barriers. Materials and methods The cross-sectional study was conducted from January 2020 to December 2021 among 161 GPs in the city of Lodz. Results Only 3.7% of physicians always advised their patients on diet and physical activity (p < 0.05). Most of the GPs (54%) provide counseling occasionally. GPs gave general advice more often to patients with chronic diseases than to patients who did not. The study showed that the chance of providing advice on eating habits or physical activity was significantly higher for the GPs who practiced physical activity (OR = 2.64; 95%Cl: 1.01–6.91, p < 0.05) and measured patient weight, height, and BMI (OR = 4.86; 95%Cl: 1.86–12.67, p < 0.001). GPs who were overweight (OR = 3.55; 95%Cl: 1.49–8.41, p < 0.01) and measured patient weight, height, and BMI (OR = 3.61; 95%Cl: 1.58–8.25, p < 0.01) were more likely to advise on nutrition or physical activity to “healthy” patients. Doctors who measured patient weight, height, and BMI advised patients with chronic diseases (OR = 6.45; 95%Cl: 2.54–16.34, p < 0.001). Over 40% of GPs believe that they are not effective in counseling. Lack of time turned out to be the main barrier to counseling for 73.3% of GPs, which was associated with heavy workload (>100 visits per week). Conclusion As many GPs doubt their effectiveness, it is recommended that GPs attend more training activities regarding counseling. In addition, organizational changes are needed to reduce patient numbers, and financial incentives are needed to improve counseling and patient measurement.
Nuevos registros del Aguilucho Alas Anchas (Buteo platypterus) en Argentina

El Aguilucho Alas Anchas (Buteo platypterus) es una rapaz migratoria que nidifica en América del Norte y pasa la temporada no reproductiva en el norte de América del Sur, extendiéndose hacia el sur por los Andes. Hasta ahora, el único registro documentado para Argentina correspondía a un individuo observado en el Parque Nacional Calilegua, provincia de Jujuy. Aquí documentamos cuatro nuevas observaciones de Buteo platypterus provenientes de la misma localidad y presentamos información general sobre el hábitat y las características del plumaje. Analizamos la morfología y la coloración del plumaje de los individuos observados y las comparamos con las de otras especies con las cuales podrían confundirse en el área. Además, evaluamos estos registros a la luz de la distribución conocida para la especie en América del Sur. Nuestras observaciones extienden la distribución austral de Buteo platypterus unos 500 km al sur de su distribución conocida.