Miracle-dz/UniFAR-FTUs huggingface dataset:
A small viral potassium ion channel with an inherent inward rectification

Some algal viruses have coding sequences for K+ channels with structural and functional characteristics of pore modules of complex K+ channels. Here we exploit the immense structural diversity of natural channel orthologs to discover new basic principles of structure/function correlates in K+ channels. The comparative analysis of three similar K+ channels with monomer sizes ≤ 86 amino acids (AA) shows that one channel (Kmpv1) generates an ohmic conductance in HEK293 cells while the other two channels (KmpvSP1, KmpvPL1) exhibit typical features of canonical Kir channels. Like Kir channels, the rectification of the viral channels is a function of the K+ driving force. Reconstitution of KmpvSP1 and KmpvPL1 in planar lipid bilayers showed rapid channel fluctuations only at voltages negative of the K+ reversal voltage. This rectification was maintained in KCl buffer with 1 mM EDTA, which excludes blocking cations as the source of rectification. This means that rectification of the viral channels must be, unlike Kir channels, an inherent property of the channel proteins. The structural basis for rectification was investigated by a chimera between rectifying and non-rectifying channels as well as point mutations, which made the rectifying channels similar to the ohmic conducting channel. The results of these experiments exclude the domain, which connects the two transmembrane helixes and which includes the pore helix and the selectivity filter, as playing a major role in rectification; inward rectification must be conferred by the transmembrane domains. The finding that a swapping of the AA, which is typical for the two inward rectifiers, with the respective AA from Kmpv1 did not compromise rectification suggests that tertiary or quaternary structural interactions are responsible for this type of gating.
Depressive Symptoms and Burnout in Football Players: A Systematic Review

The purpose of this article was to systematically review and organise the available literature devoted to the topic of depressive symptoms and burnout in football players. A systematic search was conducted in Web of Science, Scopus, SPORTdiscus, PubMed, and Psychinfo for articles published up to June 2020. The searches yielded 1589 articles, and after the screening process, a total of 18 studies met the eligibility criteria and were included for review. Playing position and conflicts with coach/management seems to have a direct influence on the prevalence of depressive symptoms in current players as do the injuries and life events of former players. During the pre-competition phase, most of the athletes displayed reduced rates, indicating burnout. An exploration of the mental health of football players will help to create models of care and guide professionals so that they may help players achieve better performance while also having better wellbeing. Understanding how to prevent and cope with the emotional wellbeing of football players will be possible to guide players and coaches.
Coping Strategies in the Family and School Ecosystem

The objective of the present study is to study children’s coping strategies used when faced with different stressors in their daily life (problems with their school work, problems getting along with other children and problems at home with people in their family), in a vulnerable social environment. This objective was evaluated through the Child Coping Questionnaire. The research for this study was conducted through a descriptive, inferential, quantitative, ex post facto design. The sample consisted of 50 schoolchildren from one suburban primary school in Madrid, Spain. The ages of the children range from 8 to 11 years. At present, almost 25% families are in a vulnerable situation. This instrument measures 14 coping categories that analyse positive and self-effective attitudes to favour socio-communicative processes and decision-making in situations of conflict between students. The results indicate that what bothers children the most is, first of all, problems getting along with other children (35.8%), problems with their school work (30.2%) and problems at home with people in their family (24.5%). Regarding their lifestyle outside the school environment and relationship with their family, 38% of participants spend a lot of time outside their home, according to our findings. This result can explain the difficulties in completing their homework that these children have. This can also trigger a curricular gap compared to their reference group, which can sometimes lead to school failure.
Introduction. Amílcar Cabral and the Idea of Anticolonial Revolution

This article intends to be a contribution to the present issue, entirely dedicated to Amílcar Cabral and the Idea of the Anticolonial Revolution. The main goal is to shift and decentralize the emphasis so far exclusively laid upon the historical weight of Cabral as an individual. In other words, we propose a more inclusive analysis and an approach that does not overlook the multiplicity of interactions and connexions, as well as how several interconnected elements hardly related to the figure of Cabral fostered the process of the liberation struggle of Guinea and Cabo Verde and brought it into fruition. In this introductory considerations we will address three main topics. First, we address Amílcar Cabral and PAIGC’s liberation project of struggle in relation with the domestic and transnational wave of decolonization from the same period. Secondly, we briefly outline the different topics so far discussed in the academic and non-academic works related to the history of liberation of Guinea and Cabo Verde, as well as how certain perspectives influenced the understanding of this history. Finally, we highlight the pertinence of the topic of this volume and identify the contribution of each of the different case studies presented in the articles.
Influence of Cultural Identity on Tourists’ Authenticity Perception, Tourist Satisfaction, and Traveler Loyalty

Intangible cultural heritage is a natural fit for tourism development due to its extensive cultural and artistic value. Authenticity is important in the development of intangible cultural heritage tourism. This case study considered Celadon Town, a classic scenic spot of intangible cultural heritage in Zhejiang Province, China, to design questionnaires and a research model involving cultural identity, authenticity perception, tourist satisfaction, and traveler loyalty. This model was used to explore the indigenous presentation of authenticity, that is, the “Traditional Firing Technique of Longquan Celadon,” and its impact on tourist satisfaction and loyalty. On the basis of the research model and hypotheses, relevant data were collected through a questionnaire survey, tested, and analyzed using a structural equation model (SEM). Findings indicate that authenticity of intangible cultural heritage has a significant positive effect on destination satisfaction and loyalty, which supplements related research on the authenticity of intangible cultural heritage destinations. This study advocates that building a characteristic town is a unique development mode of intangible cultural heritage tourism. The model integrates the cultural and tourism attributes of intangible cultural heritage. Based on this development model, the study offers related suggestions for the construction of authenticity and the realization of long-term development of tourism destinations.
The earthquake arrest zone

Earthquake ruptures are generally considered to be cracks that propagate as fracture or frictional slip on pre-existing faults. Crack models have been used to describe the spatial distribution of fault offset and the associated static stress changes along a fault, and have implications for friction evolution and the underlying physics of rupture processes. However, field measurements that could help refine idealized crack models are rare. Here, we describe large-scale laboratory earthquake experiments, where all rupture processes were contained within a 3-m long saw-cut granite fault, and we propose an analytical crack model that fits our measurements. Similar to natural earthquakes, laboratory measurements show coseismic slip that gradually tapers near the rupture tips. Measured stress changes show roughly constant stress drop in the centre of the ruptured region, a maximum stress increase near the rupture tips and a smooth transition in between, in a region we describe as the earthquake arrest zone. The proposed model generalizes the widely used elliptical crack model by adding gradually tapered slip at the ends of the rupture. Different from the cohesive zone described by fracture mechanics, we propose that the transition in stress changes and the corresponding linear taper observed in the earthquake arrest zone are the result of rupture termination conditions primarily controlled by the initial stress distribution. It is the heterogeneous initial stress distribution that controls the arrest of laboratory earthquakes, and the features of static stress changes. We also performed dynamic rupture simulations that confirm how arrest conditions can affect slip taper and static stress changes. If applicable to larger natural earthquakes, this distinction between an earthquake arrest zone (that depends on stress conditions) and a cohesive zone (that depends primarily on strength evolution) has important implications for how seismic observations of earthquake fracture energy should be interpreted.
The change in pre-service primary teachers’ possible selves in relation to science teaching

ABSTRACT This study examines pre-service primary school teachers’ (PSTs’) possible selves in relation to science teaching and the ways in which these possible selves change over time. This longitudinal study adds to the body of knowledge by examining PSTs’ possible selves at various time points throughout their teacher preparation: three PSTs, selected from a wider sample, were interviewed three times about their future aspirations as science teachers. Narrative analysis was applied to show the changes in three PSTs’ possible selves in response to the science methods course and teaching practicum. PSTs articulated general, collective and specific hoped-for and feared possible selves. Our findings highlight the changes in the possible selves that pertain to their cognitive and affective dimensions and occurred in different stages of teacher education. These changes were significant for the development of PSTs’ identity. The implications of these findings are discussed in the context of science teaching.
New spiders (Araneae: Palpimanoidea) from the Jurassic Yanliao Biota of China

Several new spider specimens, belonging to the superfamily Palpimanoidea, are described from the Middle–Upper Jurassic Haifanggou Formation (early assemblage of the Yanliao Biota) of Inner Mongolia, China. Two new genera and species, and a new species in the genus Sinaranea Selden, Huang & Ren, 2008, are described. Caestaranea jurassica gen. et sp. nov. is described on the basis of several adult males, typified by boxing-glove shaped pedipalps, as well as females and juveniles. Onychopalpus thomisoides gen. et sp. nov. is the largest palpimanoid known, and its habitus resembles that of a crab spider (Thomisidae) in having large, laterigrade anterior legs with rows of macrosetae on the femora and a squat, rotund opisthosoma. However, the distinctive adult male pedipalp bears a pectinate claw, so the holotype specimen is a subadult male; the other specimens referred to this species are smaller juveniles. Three new specimens of Sinaranea metaxyostraca Selden, Huang & Ren, 2008, including two adult males, are described here, and the new species S. brevicrus sp. nov., which has shorter legs than the type species, is described from an adult male and an adult female. These new palpimanoids substantially increase the diversity of the superfamily in the Middle Jurassic, and the unusual Onychopalpus provides evidence for a different mode of life for these spiders. http://www.zoobank.org/urn:lsid:zoobank.org:pub:D7726F4B-349E-4C2B-960D-371C27A6B77F
Associations between Emotional Eating and Metabolic Risk Factors at Adolescents with Obesity

Purpose: This study aimed to determine whether emotional eating (EE) and uncontrolled eating (UCE) scores affect the metabolic risk factors in obese adolescents. Methods: A sample of 100 adolescents have BMI-SDS between 1.41 and 2.83 (aged 12-17 years) was selected. EE and UCE scores were estimated using the TFEQ21. The association of EE and UCE with anthropometric data, lipid profile, glucose profile, liver enzymes, and inflammation factors was assessed in boys and girls. Results: Using Spearman rank correlation, EE scores significantly correlated with uric acid (r = 0.393 and P = 0.001), CRP (r = 0.273 and P = 0.017), TG (r = 0.317 and P = 0.001), TC (r = 0.258 and P = 0.019) and VAI (r = 0.276 and P = 0.034). Also UCE scores were showed positive correlation with CRP (r = 0.257 and P = 0.024). Conclusion: In conclusion, interrelationships tend to exist between EE and triglyceride, uric acid, visceral adiposity index, and CRP levels among obese adolescents.
Hif-1α stabilisation polarises macrophages via cyclooxygenase/prostaglandin E2 in vivo

Macrophage subtypes are poorly characterised in disease systems in vivo. The initial innate immune response to injury and infectious stimuli through M1 polarisation is important for the outcome of disease. Appropriate macrophage polarisation requires complex coordination of local microenvironmental cues and cytokine signalling to influence immune cell phenotypes. If the molecular mechanisms behind macrophage polarisation were better understood then macrophages could be pharmacologically tuned to better deal with bacterial infections, for example tuberculosis. Here, using zebrafish tnfa:GFP transgenic lines as in vivo readouts of M1 macrophages, we show that hypoxia and stabilisation of Hif-1α polarises macrophages to a tnfa expressing phenotype. We demonstrate a novel mechanism of Hif-1α mediated macrophage tnfa upregulation via a cyclooxygenase/prostaglandin E2 axis, a mechanism that is conserved in human primary macrophages. These findings uncover a novel macrophage HIF/COX/TNF axis that links microenvironmental cues to macrophage phenotype that may have implications in inflammation, infection and cancer, where hypoxia is a common microenvironmental feature and where cyclooxygenase and Tnfa are major mechanistic players.
Vitamin D and Metabolic Diseases: Growing Roles of Vitamin D

Vitamin D, a free sunshine vitamin available for mankind from nature, is capable to avert many health-related critical circumstances. Vitamin D is no more regarded as a nutrient involved in bone metabolism alone. The presence of vitamin D receptor in a number of tissues implies that vitamin D has various physiological roles apart from calcium and phosphorus metabolism. Low serum vitamin D has been found to be associated with various types of metabolic illness such as obesity, diabetes mellitus, insulin resistance, cardiovascular diseases including hypertension. Various studies reported that vitamin D insufficiency or deficiency in linked with metabolic syndrome risk. This review focuses on various metabolic diseases and its relationship with serum vitamin D status.
Midpoints, endpoints and the cognitive structure of events

ABSTRACT Events unfold over time, i.e. they have a beginning and endpoint. Previous studies have illustrated the importance of endpoints for event perception and memory. However, this work has only discussed events with a self-evident endpoint, and the internal temporal structure of events has not received much attention. In this study, we hypothesise that event cognition computes boundedness, an abstract feature of the internal temporal structure of events. We further hypothesise that sensitivity to boundedness affects how individual temporal slices of events (such as event midpoints or endpoints) are processed and integrated into a coherent event representation. The results of three experiments confirm these hypotheses. In Experiment 1, viewers identified the class of bounded (non-homogeneous, culminating) and unbounded (homogeneous, non-culminating) events in a categorisation task. In Experiments 2 and 3, viewers reacted differently to temporal disruptions in bounded versus unbounded events. We conclude that boundedness shapes how events are temporally processed.
Digital support seeking in adolescent girls: A qualitative study of affordances and limitations

While digital communication is almost universal amongst adolescents, we do not yet know why adolescent girls seek support electronically or how they perceive this support. The prevalence of adolescent girls’ informal digital support seeking was determined by a self-report questionnaire with 186 early and middle adolescent girls (M age = 13.64 years), drawn from four socioeconomically advantaged schools in Australia. Digital support seeking from friends was extremely common, with 73.66% seeking emotional support and 85.48% seeking academic support. Next, to determine perceptions of digital support seeking, we conducted in-depth semi-structured interviews with a representative subsample of 31 girls (M age = 13.95 years). Interview data was analysed using inductive thematic analysis. Themes of friendship and emotional self-regulation emerged as perceived benefits. Girls perceived digital support to be poorer in quality than face-to-face support, and were particularly concerned about limitations to privacy and the disclosure of confidential information. Several maladaptive behaviours such as using digital support seeking to conceal or avoid emotion were identified. There was variation in the attitudes of the sample, and four groups of girls with distinct attitudes towards digital emotional support seeking were identified. Implications for supporting adolescents to effectively seek support electronically and face-to-face are discussed.
Hybridizing Deep Learning and Neuroevolution: Application to the Spanish Short-Term Electric Energy Consumption Forecasting

The electric energy production would be much more efficient if accurate estimations of the future demand were available, since these would allow allocating only the resources needed for the production of the right amount of energy required. With this motivation in mind, we propose a strategy, based on neuroevolution, that can be used to this aim. Our proposal uses a genetic algorithm in order to find a sub-optimal set of hyper-parameters for configuring a deep neural network, which can then be used for obtaining the forecasting. Such a strategy is justified by the observation that the performances achieved by deep neural networks are strongly dependent on the right setting of the hyper-parameters, and genetic algorithms have shown excellent search capabilities in huge search spaces. Moreover, we base our proposal on a distributed computing platform, which allows its use on a large time-series. In order to assess the performances of our approach, we have applied it to a large dataset, related to the electric energy consumption registered in Spain over almost 10 years. Experimental results confirm the validity of our proposal since it outperforms all other forecasting techniques to which it has been compared.
Building organizational innovation through HRM, employee voice and engagement

PurposeTo investigate how HRM in an established organization can support employee voice and engage employees to be innovative in their everyday lived experience.Design/methodology/approachThe research is based on a case study of an innovation event in an organization, where 27 employees were interviewed about the emotional, cognitive and behavioral aspects of their engagement in innovation.FindingsFindings highlight the importance of continuing HRM's involvement during an entire event process to connect innovation events with everyday work. HRM has a central role in initiatives that intend to support voice and stimulate the engagement of diverse employees in innovation in established firms.Research limitations/implicationsThis was a qualitative and cross-sectional case study of one organization and one event offered two years in a row.Practical implicationsIn order to promote innovation, HR and senior management should foster an environment that motivates employees and promotes voice behavior (Morrison, 2014). HRM can create multiple methods of engagement, acknowledging the diversity of the workforce profile and its specific needs. HRM has an important role within an innovation strategy; as it can, together with other areas, create, develop and maintain actions that support and recognize innovative ideas and encourage employees to become actively engaged with the inclusion of innovation in their daily work life. Specifically, innovation exercises are an activity with much potential to foster voice and promote engagement towards innovation.Originality/valueWe develop a model proposing relationships between HRM, employee voice, employee engagement, cross-department collaboration and innovation. The study also considers the engagement of a diverse group of employees in an established company context.
Genomic signatures of clonality in the deep water kelp Laminaria rodriguezii

The development of population genomic approaches in non‐model species allows for renewed studies of the impact of reproductive systems and genetic drift on population diversity. Here, we investigate the genomic signatures of partial clonality in the deep water kelp Laminaria rodriguezii, known to reproduce by both sexual and asexual means. We compared these results with the species Laminaria digitata, a closely related species that differs by different traits, in particular its reproductive mode (no clonal reproduction). We analysed genome‐wide variation with dd‐RAD sequencing using 4,077 SNPs in L. rodriguezii and 7,364 SNPs in L. digitata. As predicted for partially clonal populations, we show that the distribution of FIS within populations of L. rodriguezii is shifted toward negative values, with a high number of loci showing heterozygote excess. This finding is the opposite of what we observed within sexual populations of L. digitata, characterized by a generalized deficit in heterozygotes. Furthermore, we observed distinct distributions of FIS among populations of L. rodriguezii, which is congruent with the predictions of theoretical models for different levels of clonality and genetic drift. These findings highlight that the empirical distribution of FIS is a promising feature for the genomic study of asexuality in natural populations. Our results also show that the populations of L. rodriguezii analysed here are genetically differentiated and probably isolated. Our study provides a conceptual framework to investigate partial clonality on the basis of RAD‐sequencing SNPs. These results could be obtained without any reference genome, and are therefore of interest for various non‐model species.