Miracle-dz/UniFAR-FTUs huggingface dataset:
Seasonal Effects of Glucosinolate and Sugar Content Determine the Pungency of Small-Type (Altari) Radishes (Raphanus sativus L.)

Kimchi made from small-type (Altari) radishes grown in late spring is more pungent than that made from autumn-grown Altari radishes, which poses a major challenge in the kimchi industry. The mechanism through which the pungency of Altari radish changes seasonally has not been intensively investigated. In this study, three small-type radish cultivars with different pungency levels were cultivated in spring and autumn to identify the factors affecting the seasonal-dependent pungency of small-type radishes. The contents of pungency-related metabolite glucoraphasatin and other polar metabolites were analyzed. Although a previous study reported that the glucoraphasatin concentration affects the pungency of radish, in the current study, the concentration of neither glucoraphasatin nor its hydrolysis product (raphasatin) could fully explain the change in the pungency associated with radish cultivars grown in the two seasons. The change in the pungency of radish by season may be explained by the ratio of raphasatin content to total sweetness of sugars. In addition, the polar metabolites that differ with season were analyzed to identify seasonal biomarkers and understand the seasonal changed physio-biochemistry.
Autophagy Contributes to Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Tumors

Metabolic reprogramming is a feature of cancers for which recent research has been particularly active, providing numerous insights into the mechanisms involved. It occurs across the entire cancer process, from development to resistance to therapies. Established tumors exhibit dependencies for metabolic pathways, constituting vulnerabilities that can be targeted in the clinic. This knowledge is of particular importance for cancers that are refractory to any therapeutic approach, such as Pancreatic Ductal Adenocarcinoma (PDAC). One of the metabolic pathways dysregulated in PDAC is autophagy, a survival process that feeds the tumor with recycled intracellular components, through both cell-autonomous (in tumor cells) and nonautonomous (from the local and distant environment) mechanisms. Autophagy is elevated in established PDAC tumors, contributing to aberrant proliferation and growth even in a nutrient-poor context. Critical elements link autophagy to PDAC including genetic alterations, mitochondrial metabolism, the tumor microenvironment (TME), and the immune system. Moreover, high autophagic activity in PDAC is markedly related to resistance to current therapies. In this context, combining autophagy inhibition with standard chemotherapy, and/or drugs targeting other vulnerabilities such as metabolic pathways or the immune response, is an ongoing clinical strategy for which there is still much to do through translational and multidisciplinary research.
FLIGHT DYNAMICS OF SMALL VEHICLES

Experimental studies of both the unsteady aerodynamics of micro air vehicles [MAVs] utilizing flapping wings and various active flow control strategies for flexible aerodynamic surfaces are described. Flow visualization and lift and thrust measurements clearly show that a stable unsteady leading edge vortex and its interaction with the stiffness distribution of a flapping wing determine the aerodynamic performance of the MAV. Two active flow control strategies, one for local vortex control using electrostatically controlled checkvalve actuators fabricated directly on the wing, and the other involving instantaneous variation of the wing’s angular speed to achieve global vortex control, are also presented. Combined with a novel distributed control algorithm (the Gur Game), they light a path toward adaptive flow control of flexible surfaces.
Biodiversity of the Genus Trichoderma in the Rhizosphere of Coffee (Coffea arabica) Plants in Ethiopia and their Potential Use in Biocontrol of Coffee Wilt Disease

The present study investigated the distribution status and biodiversity of Trichoderma species surveyed from coffee rhizosphere soil samples from Ethiopia and their potential for biocontrol of coffee wilt disease (CWD) caused by Fusarium xylarioides. Trichoderma isolates were identified based on molecular approaches and morphological characteristics followed by biodiversity analysis using different biodiversity indices. The antagonistic potential of Trichoderma isolates was evaluated against F. xylarioides using the dual confrontation technique and agar diffusion bioassays. A relatively high diversity of species was observed including 16 taxa and 11 undescribed isolates. Trichoderma asperellum, T. asperelloides and T. longibrachiatum were classified as abundant species, with dominance (Y) values of 0.062, 0.056 and 0.034, respectively. Trichoderma asperellum was the most abundant species (comprising 39.6% of all isolates) in all investigated coffee ecosystems. Shannon’s biodiversity index (H), the evenness (E), Simpson’s biodiversity index (D), and the abundance index (J) were calculated for each coffee ecosystem, revealing that species diversity and evenness were highest in the Jimma zone (H =1.97, E = 0.76, D = 0.91, J = 2.73). The average diversity values for Trichoderma species originating from the coffee ecosystem were H = 1.77, D = 0.7, E = 0.75 and J = 2.4. In vitro confrontation experiments revealed that T. asperellum AU131 and T. longibrachiatum AU158 reduced the mycelial growth of F. xylarioides by over 80%. The potential use of these Trichoderma species for disease management of F. xylarioides and to reduce its impact on coffee cultivation is discussed in relation to Ethiopia’s ongoing coffee wilt disease crisis.
High Output Heart Failure in Multiple Myeloma: Pathogenetic Considerations

Simple Summary Multiple myeloma is a plasma cell disorder that accounts for around 10% of all haematological malignancies. This neoplasia is often associated with a significant prevalence of cardiovascular complications resulting from several factors, unrelated and/or related to the disease. Among cardiovascular complications, the high output heart failure is of great importance as it is related to a worse prognosis for patients. It is important to point out that, despite the availability of more and more numerous and effective drugs, myeloma remains an incurable disease, with frequent relapses and several treatment lines, with the need, therefore, for a careful evaluation of patients, especially from a cardiological point of view. For this reason, we are proposing a comprehensive overview of different pathogenetic mechanisms responsible for high output heart failure in multiple myeloma, including artero-venous shunts, enhanced angiogenesis, glutamminolysis, hyperammonemia and hemorheological alterations, with the belief that a multidisciplinary approach, in clinical evaluation is critical for the optimal management of the patient. Abstract The high output heart failure is a clinical condition in which the systemic congestion is associated to a high output state, and it can be observed in a non-negligible percentage of hematological diseases, particularly in multiple myeloma, a condition in which the risk of adverse cardiovascular events may increase, with a worse prognosis for patients. For this reason, though an accurate literature search, we provided in this review a complete overview of different pathogenetic mechanisms responsible for high output heart failure in multiple myeloma. Indeed, this clinical finding is present in the 8% of multiple myeloma patients, and it may be caused by artero-venous shunts, enhanced angiogenesis, glutamminolysis, hyperammonemia and hemorheological alterations with increase in plasma viscosity. The high output heart failure in multiple myeloma is associated with significant morbidity and mortality, emphasizing the need for a multidisciplinary approach.
Prevention of Severe Vestibular Hypofunction after Systemic Gentamicin

The importance of early evaluation by a neurotologist in patients with infective endocarditis treated with systemic gentamicin and its impact on the patients’ quality of life was evaluated. This is a longitudinal retrospective cohort study of 29 patients who received intravenous gentamicin for the treatment of infective endocarditis. Patients were classified into two groups: group A, before a neurotologist was included in the treatment protocol, and group B, after the inclusion of a neurotologist. The frequency of the different symptoms in each group was measured, and the gain of the vestibulo-ocular reflex (VOR) and its relationship with the presence of oscillopsia. In total, 13 and 16 patients were assigned to groups A and B, respectively. The mean gain of the VOR measured using the video head impulse test in group A was 0.44 in the best side and 0.39 in the worst side. In group B, the mean gain was 0.71 (best side) and 0.64 (worst side) (p < 0.0001). The patients who complained about oscillopsia had a main gain of 0.41 in the best side and 0.35 in the worst side. Evaluation of vestibular function should be included in the infective endocarditis treatment protocol, including the adverse effects of systemic gentamicin.
From Face-to-Face to Online Mode: Nursing Students' Learning Experiences during COVID-19 Pandemic

The repeated episodes of global pandemic created by COVID-19 has lead several universities and institutes switching their mode of education from traditional face-to-face to online mode using different platforms such as Zoom, Google Meet, etc. to mitigate the impact on learning. Nursing education system has been affected such as student’s learning, gap in admissions and delay in graduation which could in turn lead to nursing shortage in near future. The consequences, challenges and barriers faced by students must be explored and addressed so as to improve the quality of online system of nursing education in order to yield smooth production of nursing graduates. This narrative inquiry explores the stories of two nursing student’ experiences who were adapting online mode of education during COVID-19 pandemic. The findings of the study explored as feeling of uncertainty, COVID-19 prompted new learning, modes of teaching and learning and barriers to online learning such as technological competencies, lack of interaction, the Internet issues. The study highlighted that there is a need of social interactions between students and teachers and among students for an active learning process. In addition, practical courses remain the major concern in nursing and it can lead to anxiety and delay graduation among nursing students. So, concerned authority must be alerted for adopting alternative mode of clinical education as well.
What to buy, Pepper? – Bridging the Physical and the Digital World with Recommendations from Humanoid Robots

ABSTRACT While e-commerce has flourished in the past decades, brick-and-mortar retail stores face increasing challenges in attracting customers. Prior research indicates that humanoid robots may constitute a promising means to counteract this development. However, their capability to acquire and make use of rich information from the physical world (e.g. regarding customers’ physical characteristics) in combination with knowledge from (online) databases has not been adequately exploited yet. Thus, we aim at bringing together the best of the physical and the digital world by supplementing the traditional consultation process in brick-and-mortar retail stores with humanoid robots. Following a design-oriented approach, we propose a novel knowledge-based humanoid robot recommender process. We demonstrate our approach in cooperation with an optician and evaluate it using a customer survey and expert interviews. Results show that the approach achieves the design objectives and yields high customer satisfaction.
Quantification of weather relationship with seed vigour development and germination percentage in desi cotton (Gossypium arboreum L.)

The present investigation was carried out during 2015 and 2016 at Research Farm of Cotton Section, Department of Genetics and Plant Breeding, CCS Haryana Agricultural University, Hisar to study the impact of weather parameters on seed development in desi cotton under varying environmental conditions. The experiment was comprised of three varieties of desi cotton namely, HD 123, HD 324 and HD 432 planted under three environmental conditions (early, normal and late sown). The results revealed that seed development as indicated by germination, protein content, gossypol content and seed vigour was affected significantly by delayed sowing. The seed quality parameters of April sown cotton crop were maximum except gossypol content.The cotton seed of variety HD 432 recorded the highest seed vigour and germination (54.49%) while the lowest values were observed in cotton seed of variety HD 123 (49.5%). Cotton seed vigour development was correlated with weather parameters prevailed during seed development phase pooled for both seasons. Weather factors and thermal indices had positive correlation with seed vigour protein content and germination except maximum temperature which was negatively associated whereas this response was reverse in case of gossypol content of cotton seeds.
INOVASI PEMBELAJARAN BAHASA INGGRIS BERBASIS ICT DALAM RANGKA MENINGKATKAN MUTU PENDIDIKAN

It is an undeniable fact that most of our students nowadays can enjoy havingnew technology either at homes or at schools. For this, it is quite possible for them tohave ICT for learning. The purpose of having this kind of method is that students willhave two advantages at the same time, i.e. the linguistic aspects and the content. Forthe linguistic aspects, firstly, they will learn the English sound system throughspelling, secondly the grammar, by combining words into longer utterances, andfinally the choice of words or vocabulary. While for the content, ICT let the studentslearn (assisted by the teacher) the variety of language used within a certain subject.Teaching technique using chalk and talk or explanation is not popular anymore. It isthen suggested that the teacher uses internet within his teaching learning process and itis also compulsory for the students to learn to use it. The Internet is a must, because itcan be used (1) as the source of knowledge (2) as an aid for learning (instructional aid)(3) as teaching or learning facility (4) as a standard of competency (5) as anadministrative equipment (6) as a supporting equipment for the school management(7) as an educational infrastructure. Beside the aforementioned aspects, there areadditional factors to consider. Among others are (a) the environmental factor whichconsists of school or institution holding the activity (b) students who learn, their ages,social and economical background, the language and literacy of IT, the variety oflearning (c) the teacher, consists of the background of the teacher, the age, theteaching style, the experience and the personality (d) factors of technology whichconsists of computer, software, internet network and other application of EducateNetat schools.Kata kunci: ICT, standar kompetensi, infrastruktur, literatur, jaringan internet
Pruning and fertilization in young Pinus greggii plantations established at Durango, Mexico

Objective: To evaluate the effects of pruning and fertilization on the growth of Pinus greggii plantationsestablished at Durango state, Mexico.Design/methodology/approach: In a plantation (Durango), pruning was applied in three intensities (0, 50,and 75%) in a randomized complete block design. Four years later, the basal diameter (Db), normal diameter(ND), total plant height (PH), and stem height (SH) were evaluated. In another plantation (La Soledad), twopruning levels (0 and 50%) and foliar fertilization (with and without application) were applied in a completelyrandomized factorial design. Seven months later, Db, PH, and crown diameter (CD) were assessed. Theanalysis of their variance and means comparison test (Tukey, 0.05) were performed.Results: In Durango, pruning diminished the Db and PH, but increased the SH (p0.01). In La Soledad,pruning also affected growth. The Db, PH, and CD were lower (p0.01) when trees were pruned. Fertilizationaffected the PH (p0.05) and CD (p0.01) as well. The PH and the CD for both pruned and unpruned treesincreased with fertilization.Limitations/implications: Pruning at 50 and 75% intensities are not suitable for P. greggii because it reducestheir growth.Findings/conclusions: Fertilization favors the growth of P. greggii planted on low fertility soils for both prunedand unpruned trees, but the pruning and fertilization interaction should be examined in detail for a longerperiod
Identifying Corporate Performance Factors Based on Feature Selection in Statistical Pattern Recognition: METHODS, APPLICATION, INTERPRETATION

This publication summarizes and extends methodology of feature selection (FS) and pattern recognition in search for competitiveness factors and methodology of corporate financial performance (CFP) measurement. Several methods were evaluated and Dependency-Aware Feature Ranking combined with non-linear regression model were applied. Also, this publication suggests and verifies methodology of interpretation results of the FS methods. For start was employed multidimensional linear regression, succeeded by clustering companies according to the factors identified by FS into homogenous groups, dividing them into quartiles based on their CFP and identifying similar values of the factors. This way was captured the non-linearity in the data.
Performance Analysis of a New Coded TH-CDMA Scheme in Dispersive Infrared Channel with Additive Gaussian Noise

Abstract We consider a time-hopping based multiple access scheme introduced in [1] for communication over dispersive infrared links, and evaluate its performance for correlator and matched filter receivers. In the investigated time-hopping code division multiple access (TH-CDMA) method, the transmitter benefits a low rate convolutional encoder. In this method, the bit interval is divided into Nc chips and the output of the encoder along with a PN sequence assigned to the user determines the position of the chip in which the optical pulse is transmitted. We evaluate the multiple access performance of the system for correlation receiver considering background noise which is modeled as White Gaussian noise due to its large intensity. For the correlation receiver, the results show that for a fixed processing gain, at high transmit power, where the multiple access interference has the dominant effect, the performance improves by the coding gain. But at low transmit power, in which the increase of coding gain leads to the decrease of the chip time, and consequently, to more corruption due to the channel dispersion, there exists an optimum value for the coding gain. However, for the matched filter, the performance always improves by the coding gain. The results show that the matched filter receiver outperforms the correlation receiver in the considered cases. Our results show that, for the same bandwidth and bit rate, the proposed system excels other multiple access techniques, like conventional CDMA and time hopping scheme.
Public R&D Projects-Based Investment and Collaboration Framework for an Overarching South Korean National Strategy of Personalized Medicine

Since the South Korean government designated personalized medicine (PM) as a national strategic task in 2016, it has spared no investment to achieve its goals, which were recently accelerated by the COVID-19 pandemic. This study analyzed investment trends in 17 regions and eight technology clusters related to PM, consisting of 5727 public R&D projects worth USD 148.5 million, from 2015 to 2020. We also illustrated the level of investment for different PM-related technology clusters in each region; various research organizations explicitly verified comparable innovation capabilities for all eight technology fields in 17 regions, showing individual differences in technology areas per region. Our framework provided information to allow implementation of two goals: administering successful PM and improving regional equality in public health and healthcare according to technical and organizational levels. This study empirically demonstrates that it can provide a precise overarching innovation scheme with regional, technical, and organizational dimensions to establish collaboration among different stakeholders, thereby creating a foundation for an overarching national PM strategy.
Corrected Tilt Calculation for Atmospheric Pressure-Induced Seismic Noise

In a literature search on the coupling of wind-generated pressure fluctuations into seismic noise, it was noticed that the expression for the angular tilt induced by pressure fluctuations in the seminal paper “A preliminary investigation into the relationship between long-period seismic noise and local fluctuations in the atmospheric pressure” by G. G. Sorrells was only valid at the surface. A search of the literature which cites the Sorrells paper was performed to see if any subsequent research corrected this error, and what effect the error might have on the research. A recent paper by Tanimoto and Wang notes the correct expression for the tilt, but employs the simpler erroneous expression in the research. In this paper, we develop the correct expression for effective measured displacements and approximate expressions analogous to those of Sorrells. The resulting magnitudes and decay with depth are then displayed and compared to Sorrells. Next, the results of the literature search are discussed. The results of three papers are identified as potentially modified by the correction of the tilt calculation. Finally, it is noted that the majority of the papers referenced are not affected by the correction, since many of the papers are for near-surface displacements of very low frequencies.
ANALISIS VARIABEL-VARIABEL YANG MEMPENGARUHI KINERJA PRODUK DI PASAR UNTUK MENCAPAI KEUNGGULAN BERSAING BERKELANJUTAN

This research analyzes the effect of innovation orientation, promotion support and sales person support to product performance at market in order to enhance sustainable competitive advantage. The formulation problems in this research are to show the effect of innovation orientation to product performance on market, sales person support to product performance on market, promotion support to product performance on market, each construct with sustainable competitive advantage through product performance at market. The variables and indicators of research based on the previous research. There is a model that have been developed and four hypotheses to answer these research problems. Population of this research is Dealers managers of Toyota Avanza in Central Java amount 130 persons. This research using census method. Data analyze tools which used in this research is Structural Equation Modeling (SEM) under AMOS 4.01 program. Result from data analyzes shows that the model and the result from research can be accepted. And that this result proves that innovation orientation have an positive and significant effect to product performance on market, and next make an abbreviate in the support from sales person with product performance on market are influence by product performance on market, thus can make an conclusion that each constructs have an empiric evidence and the justification with sustainable competitive advantage through performance of product on market in a positive and significant influence.