Miracle-dz/UniFAR-FTUs huggingface dataset:
The Influence of Organizational Support, Professional Responsibility, and Job Satisfaction toward Teachers’ Performance at TK RA ‘Aisyiyah in Academic Year 2022/2023 in Jetis Sub-district of Ponorogo Regency

The purpose of this study is to find the influence of organizational support, professional responsibility, and job satisfaction toward teachers’ performance at TK RA ‘Aisyiyah in the academic year 2022/2023 in Jetis Sub-district of Ponorogo Regency. This study used a quantitative approach and was tested by regression analysis. Three independent variables included organizational support, professional responsibility, and job satisfaction. There was also a dependent variable, teachers’ performance. This study used a saturation sampling technique with 60 teachers in TK RA ‘Aisyiyah in Jetis Sub-district of Ponorogo Regency as the samples. The data toward those four variables were collected by questionnaire as the instrument. From the analyzed data, the researchers can conclude that: (1) there are positive and significant influences between the organizational support toward the teachers’ performance of TK RA ‘Aisyiyah in Jetis Sub-district of Ponorogo Regency in the amount of 8,4%, (2) there are positive and significant influences between the professional responsibility toward the teachers’ performance of TK RA ‘Aisyiyah in Jetis Sub-district of Ponorogo Regency in the amount of 32,1%, (3) there are positive and significant influences between the job satisfaction toward the teachers’ performance of TK RA ‘Aisyiyah in Jetis Sub-district of Ponorogo Regency in the amount of 11,9%, and (4) there are positive and simultaneously significant influences between organizational support, professional responsibility, and job satisfaction toward the teachers’ performance of TK RA ‘Aisyiyah in Jetis Sub-district of Ponorogo Regency in the amount of 32,5%.
Case Series of 11 CDH1 Families (47 Carriers) Including Incidental Findings, Signet Ring Cell Colon Cancer and Review of the Literature

Germline pathogenic variants in E-cadherin (CDH1) confer high risk of developing lobular breast cancer and diffuse gastric cancer (DGC). The cumulative risk of DGC in CDH1 carriers has been recently reassessed (from 40–83% by age 80 to 25–42%) and varies according to the presence and number of gastric cancers in the family. As there is no accurate estimate of the risk of gastric cancer in families without DGC, the International Gastric Cancer Linkage Consortium recommendation is not straightforward: prophylactic gastrectomy or endoscopic surveillance should be proposed for these families. The inclusion of CDH1 in constitutional gene panels for hereditary breast and ovarian cancer and for gastrointestinal cancers, recommended by the French Genetic and Cancer Consortium in 2018 and 2020, leads to the identification of families with lobular cancer without DGC but also to incidental findings of pathogenic variants. Management of CDH1 carriers in case of incidental findings is complex and causes dilemmas for both patients and providers. We report eleven families (47 CDH1 carriers) from our oncogenetic department specialized in breast and ovarian cancer, including four incidental findings. We confirmed that six families did not have diffuse gastric cancer in their medical records. We discuss the management of the risk of diffuse gastric cancer in Hereditary Lobular Breast Cancer (HLBC) through a family of 11 CDH1 carriers where foci were identified in endoscopic surveillance. We also report a new colon signet ring cancer case in a CDH1 carrier, a rare aggressive cancer included in CDH1-related malignancies.
Highlighting Hemodynamic Risks for Bioresorbable Stents in Coronary Arteries

A three-dimensional, transient computational fluid dynamics analysis was conducted on an idealised geometry of a coronary artery fitted with representative geometries of an Absorb bioresorbable vascular scaffold (BVS) or a Xience drug-eluting stent (DES) in order to identify and compare areas of disturbed flow and potential risk sites. A non-Newtonian viscosity model was used with a transient velocity boundary condition programmed with user-defined functions. At-risk areas were quantified in terms of several parameters linked to restenosis: wall shear stress, time-averaged wall shear stress, oscillatory shear index, particle residence time, and shear rate. Results indicated that 71% of the BVS stented surface area had time-averaged wall shear stress values under 0.4 Pa compared to 45% of the DES area. Additionally, high particle residence times were present in 23% and 8% of the BVS and DES areas, respectively, with risk areas identified as being more prominent in close proximity to crowns and link struts. These results suggest an increased risk for thrombosis and neointimal hyperplasia for the BVS compared to the DES, which is in agreement with the outcomes of clinical trials. It is intended that the results of this study may be used as a pre-clinical tool to aid in the design of bioresorbable coronary stents.
Construction and Validation of the Teachers' Motivation Questionnaire (TMQ): A Detailed Exploration

The teachers' motivation is crucial to the institutional value and accomplishment of goals; it greatly influences the success of institutions, particularly in educational institutions. This study aimed to develop and validate a questionnaire to assess teachers' motivation and named it as Teachers' Motivation Questionnaire (TMQ). The questionnaire contained two motivation dimensions provided by Herzberg's Two-Factor Theory of Motivation (i.e., Intrinsic and Extrinsic Motivation). The preliminary draft of the questionnaire was created after a focus group discussion on the forty-four (44) item, five (5) point Likert Scale. After ensuring content and face validity by having the items reviewed by experts and removing any items with CVR scores of less than 0.42, the questionnaire's items were whittled down to just thirty (30). Two hundred twenty-six teachers working for the school education department participated in a pilot study of the revised questionnaire. The data were processed using PLS Smart version 4, which determined the questionnaire's validity, reliability, and model fit. After removing the unsuitable items, the questionnaire was reduced to eighteen (18) items. The AVE values for extrinsic motivation items were 0.575 > 0.5, while for intrinsic motivation items were 0.633> 0.5. The Fornell-Lacker criterion value (0.828) was greater than the correlations with other latent components, 0.778 and 0.828, respectively. The Heterotrait-Monotrait ratio (HTMT) was 0.895 0.9, which is considered good. Cronbach alpha values for extrinsic motivation were 0.917 > 0.7, while for intrinsic motivation were 0.916 > 0.7. Similarly, the composite reliability (CR) values for extrinsic motivation were 0.931 > 0.7 and 0.932 > 0.7, respectively. So, the Teachers' Motivation Questionnaire (TMQ) was internally consistent, valid, and reliable. The overall study's findings approved using TMQ to investigate teachers' motivation.
DIVIDEND POLICY AND SHARE PRICE VOLATILITY IN NIGERIA

The purpose of this paper is to examine the relationship between dividend policy and share price changes in the Nigerian stock market. A multiple regression analysis is used to explore the association between share price changes and both dividend yield and dividend payout ratio. Of the two measures of dividend policy, dividend yield showed a general negative impact on share price risk. The other measure of dividend policy, dividend payout ratio, showed negative influences in some years and positive influences on others though all were at lower significant levels. The study supports the fact that dividend policy is relevant in determining share price changes for a sample of firms listed in the Nigerian Stock Exchange. The challenge for managements/accountants is to generally improve the quality of the financial statements to avoid producing wrong information which could lead to wrong decisions by investors.
Reasons for Encounters and Comorbidities in Adolescents with Intellectual Disability in General Practice: A Retrospective Analysis of Data from the Ask Study

Adolescents with intellectual disability have substantial health needs. This retrospective analysis of data from the Ask Study describes reasons for primary care encounters and the prevalence and incidence of chronic physical and mental conditions among a cohort of community-dwelling adolescents with intellectual disability. Participants attended secondary schools in southern Queensland, Australia. Primary care data were extracted from primary care records. Demographic and health information was collected using carer-completed questionnaires. Reasons for primary care encounters, disease prevalence at age 16 years, and disease incidence through adolescence were reported. Data were obtained for 432 adolescents with intellectual disability (median follow-up: 4.1 years). Skin problems (29.4 per 100 encounters) were the most common reason patients presented for primary care, followed by psychological and behavioural problems (14.4 per 100 encounters) and musculoskeletal problems (13.8 per 100 encounters). Conditions with the highest prevalence were autism spectrum disorder (18.6%) and asthma (18.1%). The prevalence of epilepsy, visual impairment, and cerebral palsy were 14.7, 11.1, and 8.0%, respectively. Gastroesophageal reflux had the highest incidence (9.4 cases per 1000 person-years). Adolescents with intellectual disability have significant healthcare needs, which general practitioners need to be aware of and address. Study findings should inform the development of training programs for general practitioners.
Sharpen statistical significance: Evidence thresholds and Bayes factors sharpened into Occam's razor

Occam's razor suggests assigning more prior probability to a hypothesis corresponding to a simpler distribution of data than to a hypothesis with a more complex distribution of data, other things equal. An idealization of Occam's razor in terms of the entropy of the data distributions tends to favor the null hypothesis over the alternative hypothesis. As a result, lower p values are needed to attain the same level of evidence. A recently debated argument for lowering the significance level to 0.005 as the p value threshold for a new discovery and to 0.05 for a suggestive result would then support further lowering them to 0.001 and 0.01, respectively.
Exploring the mediating effects of academic performance and self-esteem on the influence of sleep quality on internalizing and externalizing problems among Chinese adolescents

ABSTRACT This study examines the associations between sleep quality and internalizing and externalizing problems among Chinese adolescents and investigates whether academic performance and self-esteem function as mediators. Data were obtained from the 2018 wave of the China Family Panel Studies (CFPS), comprising a sample of 1,016 Chinese adolescents aged between 10 and 15 years. We employed multiple mediation models, using Hayes’ PROCESS macro, for data analysis. The results showed that poor sleep quality was associated with an increase in both internalizing and externalizing problems. Furthermore, academic performance and self-esteem were identified as mediators in these relationships, operating in parallel and sequential manners. Besides maintaining adequate sleep hours, interventions aimed at improving academic performance and self-esteem could potentially alleviate the adverse effects of poor sleep quality on internalizing and externalizing problems among adolescents.
The Influence of Maternal Condition on Fetal Cardiac Function during the Second Trimester

Objective: Maternal health has a direct, profound and lasting effect on the formation and development of the fetal cardiovascular system. The aim of this research was to find whether maternal age, BMI hypertension (GH) or gestational diabetic mellitus (GDM) would affect fetal cardiac function in the second trimester. Method: 329 mothers who had a fetal echocardiogram examination at the International Peace Maternity & Child Health Hospital of China Welfare Institute, Shanghai, China, from 1 January 2020 to 30 April 2020 were enrolled at the gestational age of 21 to 26 weeks (mean 22.78 ± 1.13 weeks). Single-factor analysis and multi-factor line regression analysis were used to find the contribution values of each factor to fetal cardiac function. Results: at the second trimester, maternal age had a minor influence on the fetal left ventricle diastolic function. Higher maternal BMI could cause a decrease in the fetal diastolic function of both the left and right ventricle and the systolic function of the left ventricle. Maternal hypertension and gestational diabetic mellitus had a profound influence on both the left and right fetal heart ventricles of both systolic and diastolic function. Conclusion: maternal condition will have a profound influence on fetal cardiac function as early as the second trimester.
Can Electromagnetic Fields Modulate Inflammation and Cell Death by Acting on the Immune System?

Programmed cell death constitutes a fundamental part of the immune response to viral infection. This process forms part of the host defence mechanism and also enables establishment of biomarkers of disease severity. Natural or anthropogenic sources of microwaves emit energy and may alter the ecology of the SAR-CoV-2 virus (which causes COVID-19 disease) in the environment. Determining the associated effects on the immune system and on the health of hosts with COVID-19 disease is thus important. In this review paper, we consider studies analyzing the influence of electromagnetic fields on innate and acquired immune responses in humans, and above all on preclinical experimental animal models and in vitro models, and we also consider studies analyzing immunity acquired from COVID-19 infections associated with cell death. We focus on the effects of electromagnetic fields and the influence of oxidative stress on stimulation or immunomodulation, the inflammatory response, autoimmunity and the participation of intracellular calcium channels in the immunology of COVID-19 disease. Non-ionizing radiation can activate or reduce the inflammatory response, oxidative stress and the entry of intracellular calcium and can facilitate or reduce cell death. The review of experimental study findings indicates that exposure to non-ionizing radiation can also have a bidirectional effect on the immune system, either slowing down or enhancing the processes that lead to the cell death associated with COVID-19 disease.
On quasijet bundles

We discuss the Weil approach to the bundles of quasijets and describe the inclusion of the bundle of non-holonomic r-jets into the bundle of quasijets of order r. Applying this approach we rededuce a result by Dekret characterizing non-holonomic r-jets among quasijets of order r.
Mapping in an Echo Chamber: How Cartographic Silence Frames Conservative Media’s Climate Change Denial

Maps are a key way through which the science of climate change is communicated, but as partisan divides lead to new ideologically driven consumption patterns of news sources, it is important to understand how the media uses maps across the political spectrum. In this study, we investigate how maps have been incorporated into climate change communication in conservative media. Our research has two major findings. First, compared to mainstream media, conservative media is far less likely to use maps in reporting on climate change. We call this lack of maps a “cartographic silence,” borrowing and expanding on Harley’s term. Second, when conservative media uses maps, never do they create their own maps to accompany false arguments. Instead, these maps are republished from other media or peer-reviewed science, and reframed by logical fallacies. We conclude by offering suggestions about how scientists can improve their maps in hopes that they will be less susceptible to use in conservative disinformation efforts.
Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers

Simple Summary Immunotherapy has reshaped the prognosis of several tumor types. In metastatic colorectal cancer, only tumors with microsatellite instability or mismatch repair deficiency achieve profound benefits under immune checkpoint inhibitors. As a result, immunotherapy has moved to the early stage, showing promising results in neoadjuvant settings. However, not all patients respond, and some responses are shortlived, thus highlighting the need for accurate and reliable biomarkers to identify patients who are more likely to achieve clinical benefit, as well as those patients with refractory tumors who will require a different therapeutic approach. Surprisingly, classical biomarkers such as PD-L1 expression or TMB seem to be poorly informative in MSI colorectal cancer. Therefore, the development of novel biomarkers in this population remains an unmet medical need. Abstract Microsatellite instability (MSI) is a biological condition associated with inflamed tumors, high tumor mutational burden (TMB), and responses to immune checkpoint inhibitors. In colorectal cancer (CRC), MSI tumors are found in 5% of patients in the metastatic setting and 15% in early-stage disease. Following the impressive clinical activity of immune checkpoint inhibitors in the metastatic setting, associated with deep and long-lasting responses, the development of immune checkpoint inhibitors has expanded to early-stage disease. Several phase II trials have demonstrated a high rate of pathological complete responses, with some patients even spared from surgery. However, in both settings, not all patients respond and some responses are short, emphasizing the importance of the ongoing search for accurate biomarkers. While various biomarkers of response have been evaluated in the context of MSI CRC, including B2M and JAK1/2 mutations, TMB, WNT pathway mutations, and Lynch syndrome, with mixed results, liver metastases have been associated with a lack of activity in such strategies. To improve patient selection and treatment outcomes, further research is required to identify additional biomarkers and refine existing ones. This will allow for the development of personalized treatment approaches and the integration of novel therapeutic strategies for MSI CRC patients with liver metastases.
Identification and Analysis of Sex-Biased MicroRNAs in Human Diseases

It is well known that significant differences exist between males and females in both physiology and disease. Thus, it is important to identify and analyze sex-biased miRNAs. However, previous studies investigating sex differences in miRNA expression have predominantly focused on healthy individuals or restricted their analysis to a single disease. Therefore, it is necessary to comprehensively identify and analyze the sex-biased miRNAs in diseases. For this purpose, in this study, we first identified the miRNAs showing sex-biased expression between males and females in diseases based on a number of miRNA expression datasets. Then, we performed a bioinformatics analysis for these sex-biased miRNAs. Notably, our findings revealed that women exhibit a greater number of conserved miRNAs that are highly expressed compared to men, and these miRNAs are implicated in a broader spectrum of diseases. Additionally, we explored the enriched transcription factors, functions, and diseases associated with these sex-biased miRNAs using the miRNA set enrichment analysis tool TAM 2.0. The insights gained from this study could carry implications for endeavors such as precision medicine and possibly pave the way for more targeted and tailored approaches to disease management.
Prevalence of Urinary Tract Infections in Uganda: A Systematic Review and Meta-Analysis

Urinary tract infections (UTIs) pose a significant burden on public health, affecting millions of individuals worldwide; on average, a typical Ugandan female will have an infection once a month. Understanding their epidemiology is crucial for targeted interventions. This systematic review and meta-analysis sought to synthesize existing literature on urinary tract infections in Uganda, providing a comprehensive overview of its prevalence. On June 24th, 2023 we searched two bibliographic databases PubMed and Scopus to identify studies conducted in Uganda that reported urinary tract infections. The main concepts related to this research, “urinary tract infections, “preva-lence”; “Uganda” were expanded with their variations and combined using Boolean operators (AND, OR) to formulate the final search query. The selection and inclusion of studies followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis. This study found the national pooled prevalence of urinary tract infection in Uganda to be 24.92% (95% CI: 23.407 - 26.479; I 2 = 98.85 [98.56% - 99.08%]) with Northern Uganda having the highest pooled prevalence 71.94% (63.70 - 79.23). The predominant isolates are Staphylococcus aureus, Escherichia coli, and Klebsiella
On the ecology of a small West..African lagoon

A small coastal lagoon near Tema, Ghana, has been studied from August to December 1971. Data on temperature, salinity and exchange of water with the sea are given for January to December 1971. The extreme hydrographic conditions in the lagoon cause a reduction of the fauna, as compared with a typical "open" lagoon or with the marine shore. The structure of the food web in the lagoon is given. The main part of the animal biomass consists of the gastropod Tympanotonus fuscatus var. radula and the cichlid fish Tilapia melanotheron which feed on bottom deposit and associated microorganisms and are welladapted to the rapid changes of salinity that characterize the lagoon. After the rain period (MaY-July) there is a steady increase of marine species, represented mostly by juvenile stages.
Systematic Analysis of Long Non-Coding RNAs in Inflammasome Activation in Monocytes/Macrophages

The NLRP3 inflammasome plays a pivotal role in regulating inflammation and immune responses. Its activation can lead to an inflammatory response and pyroptotic cell death. This is beneficial in the case of infections, but excessive activation can lead to chronic inflammation and tissue damage. Moreover, while most of the mammalian genome is transcribed as RNAs, only a small fraction codes for proteins. Among non-protein-coding RNAs, long non-coding RNAs (lncRNAs) have been shown to play key roles in regulating gene expression and cellular processes. They interact with DNA, RNAs, and proteins, and their dysregulation can provide insights into disease mechanisms, including NLRP3 inflammasome activation. Here, we systematically analyzed previously published RNA sequencing (RNA-seq) data of NLRP3 inflammasome activation in monocytes/macrophages to uncover inflammasome-regulated lncRNA genes. To uncover the functional importance of inflammasome-regulated lncRNA genes, one inflammasome-regulated lncRNA, ENSG00000273124, was knocked down in an in vitro model of macrophage polarization. The results indicate that silencing of ENSG00000273124 resulted in the up-regulation tumor necrosis factor (TNF), suggesting that this lncRNA might be involved in pro-inflammatory response in macrophages. To make our analyzed data more accessible, we developed the web database InflammasomeDB.