Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduced platelet glycoprotein Ibα shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen

Cardiovascular (CV) disease prevention with low-dose aspirin can be less effective in patients with a faster recovery of platelet (PLT) cyclooxygenase (COX)-1 activity during the 24-hour dosing interval. We previously showed that incomplete suppression of TXA2 over 24 hours can be rescued by a twice daily aspirin regimen. Here we show that reduced PLT glycoprotein (GP)Ibα shedding characterizes patients with accelerated COX-1 recovery and may contribute to higher thrombopoietin (TPO) production and higher rates of newly formed PLT, escaping aspirin inhibition over 24 hours. Two hundred aspirin-treated patients with high CV risk (100 with type 2 diabetes mellitus) were stratified according to the kinetics of PLT COX-1 activity recovery during the 10- to 24-hour dosing interval. Whole proteome analysis showed that PLT from patients with accelerated COX-1 recovery were enriched in proteins involved in cell survival, inhibition of apoptosis and cellular protrusion formation. In agreement, we documented increased plasma TPO, megakaryocyte maturation and proplatelet formation, and conversely increased PLT galactose and reduced caspase 3, phosphatidylserine exposure and ADAM17 activation, translating into diminished GPIbα cleavage and glycocalicin (GC) release. Treatment of HepG2 cells with recombinant GC led to a dose-dependent reduction of TPO mRNA in the liver, suggesting that reduced GPIbα ectodomain shedding may unleash thrombopoiesis. A cluster of clinical markers, including younger age, non-alcoholic fatty liver disease, visceral obesity and higher TPO/GC ratio, predicted with significant accuracy the likelihood of faster COX-1 recovery and suboptimal aspirin response. Circulating TPO/GC ratio, reflecting a dysregulation of PLT lifespan and production, may provide a simple tool to identify patients amenable to more frequent aspirin daily dosing.
Design of Experiments for Optimizing the Calendering Process in Li-Ion Battery Manufacturing

Calendering is a key yet complex manufacturing process that has varied effects on the Li-ion battery cell performance. Finding the optimal compaction can require many experiments if using the traditional one-factor-at-a-time method, which would be both complex and resource intensive. Design of Experiments (DoE) coupled with modeling via multiple linear regression (MLR) are used in this study to better understand the complex process of electrode calendering. The factors studied in this report are rolling temperature, post-calendered porosity
Analyzing Intra-Cycle Velocity Profile and Trunk Inclination during Wheelchair Racing Propulsion

The analysis of intra-cycle velocity profile of manual wheelchair (MWC) users has been used to highlight the significant role of trunk inertia in propulsion biomechanics. Maximal wheelchair linear velocity has previously been observed to be reached after the release of the handrims both during sports activities and daily life propulsion. This paper provides a combined analysis of linear velocity and trunk kinematics in elite wheelchair racing athletes during straight-line propulsion at stabilized speeds. MWC and trunk kinematics of eight athletes (level: 7 elite, 1 intermediate; classification: T54 (5), T53 (2) and T52 (1)) were monitored during 400 m races using inertial measurement units. An average propulsion cycle was computed for each athlete. The main finding of this article is the difference in propulsion patterns among the athletes, exhibiting either 1, 2 or 3 peaks in their velocity profile. A second peak in velocity is usually assumed to be caused by the inertia of the trunk. However, the presence of a second velocity peak among more severely impaired athletes with little to no trunk motion can either be associated to the inertia of the athletes’ arms or to their propulsion technique.
One-Pot Solvent-Involved Synthesis of 5-O-Substituted 5H-Chromeno[2,3-b]pyridines

Chromeno[2,3-b]pyridines are substances demanded in medicinal and material chemistry. PASE (pot, atom, and step economy) and in particular one-pot approaches are key green chemistry techniques that are applied for the synthesis of heterocyclic compounds. In this case, the PASE approach was extended with ‘component economy’, as solvent was used also as reactant (solvent-involved reaction). This approach was adopted for the one-pot synthesis of previously unknown O-substituted 5-alkoxy-5H-chromeno[2,3-b]pyridines via two-step transformation, namely the reaction of salicylaldehydes and malononitrile dimer, with the subsequent addition of alcohol. The mechanistic studies revealed the possibility of concurrent reaction. The studies aided in optimizing the reaction conditions for the best yields (77–93%). Thus, the one-pot reaction proceeds efficient and quickly, and the work-up procedure (only simple filtering) is very convenient. The structure of synthesized chromeno[2,3-b]pyridines was confirmed by 2D NMR spectroscopy.
Determinants of SMEs’ product innovation performance in Malaysia: an extended model

Abstract This paper analyzes the organizational capabilities associated with new product development of SMEs in manufacturing companies with indicators such as administrative capabilities, functional capabilities (R&D, manufacturing, and marketing), and innovative performance (new product development) in Malaysia. This study develops an extended structural model linking administrative and functional capabilities to new product development. To empirically analyze these relationships, the researchers used a questionnaire-based survey to collect data from the managers of small manufacturing firms operating in Malaysia. A total of 159 usable questionnaires were received via an online survey of SME managers in Malaysia. The questionnaire was subjected to a PLS structural equation modeling analysis to establish quantitative relationships among constructs. This empirical study confirmed four out of the five hypotheses as statistically significant. SMEs will sustain their competitive advantage by integrating and effectively utilizing their capabilities in administration, manufacturing, and marketing resources. The positive but insignificant effect of the relationship between R&D and new product development can be attributed to the small sample size in this study. However, functional capabilities through the combined mean values of R&D, manufacturing, and marketing capabilities positively and significantly affect SMEs’ new product development. The research framework offers a practical guide for SMEs to sustain their competitive advantage by integrating and effectively utilizing their administration, manufacturing, and marketing resource capabilities.
Assessment of certain plant products toxixity against Sitophilus oryzae in milled rice grains in coastal Odisha

The rice variety, Jyotirmayee was treated with plant products for the assessment of toxicity towards rice weevil Sitophilus oryzae in milled rice grains in the laboratory of Department of Entomology of College of Agriculture under Odisha University of agriculture and technology, Bhubaneswar in coastal climatic condition of Odisha. The toxicity assessment revealed that the average rate of mortality over the time and doses was significantly highest in black pepper with 81.86% mortality which was statistically at par with tobacco (80.37%), turmeric (70.00%) and chilli (68.51%). Theprobit analysis data revealed that at 24 HAT and 48 HAT the lowest LC50 value of 0.02 and 0.06% was recorded respectively in black pepper. But at 72 HAT the lowest LC50 value of 0.08% was recorded with chilli followed by turmeric (0.14%), black pepper (0.21%), eucalyptus (0.71%) and tobacco (0.95%).
Assessment of groundwater quality from Sahibabad to Modinagar Meerut Uttar Pradesh, India using water quality index

Groundwater quality and quantity both are important for the survival of human beings on this planet. In the present study an attempt has been made to assess the groundwater quality at mass using points. To fulfil the objectives of the present study, four sites (Sahibabad, Ghaziabad, Muradnagar, and Modinagar) were selected along the metro line construction from Delhi to Meerut. At all these sites, workers of metro line projects are living and working and using the groundwater for drinking purpose. Sampling was carried out from July 2021 to June 2022 using grab method of sampling. The samples were analysed for pH, total dissolved solids (TDS), total hardness (TH), calcium, magnesium, chloride, sulphate, nitrate, and fluoride. The data was processed using water quality index (WQI) and Pearson correlation metrix. TDS at all the study sites ranged from 514mg/l to 549.3mg/l and the values are above the standard limit of BIS (500mg/l). Values of TH, calcium and magnesium were found above the limits prescribed. Concentration of Chloride, nitrate, sulphate, and fluoride were found below the limits prescribed by BIS. However, nitrate is approaching to the standard limit (45mg/l). Correlation metrix shows that calcium is responsible for increasing values of TDS. As per the values of WQI, water quality of site 2 (46.7762), 3 (48.3523) and 4 (48.6281) falls in good category while at site 1 (50.9363) in poor category. There is an urgent need of strict actions to stop the increasing water pollution in the area to prevent the huge population of this area from various water related implications.
Optimization principles of calibration and information extraction

This study deals with two aspects of measurement science: the forward problem of optimal calibration and the inverse problem of optimal restoration of input data based on the output of the measurement system. Within the frame of the forward problem a general methodology is developed and introduced for the choice of the optimal fitting set points to result with the minimal uncertainty of a calibration curve of any order. Examples of the application of this methodology to the optimal determination of calibration polynomials up to the seventh degree are provided. Within the frame of the inverse problem, a methodology is developed for the optimal restoration of input data given the response function of the measurement system and taking into account a priori information regarding statistical features of the input data. The methodology is illustrated by three examples of its application to practical systems. It is implied that establishing a unified methodology for the optimization of both the forward and the inverse problems is feasible.
Effect of dietary supplementation of prebiotic on growth performance, immune response and intestinal microbial load in broiler chickens

The experiment was conducted to study the effect of using prebiotic (mannan oligosachharide -MOS) in place of antibiotic growth promoter (AGP) on performance, immune response and intestinal microbial load in broiler chickens. Day-old broiler chicks (192) were randomly distributed into 20 groups each of 8 chicks (4 treatments Ã— 6 replicates). Four experimental diets T1, T2, T3 and T4 were formulated to contain no additive, bacitracin methylene di-salicylate (BMD) at 20 mg/kg diet, MOS at 0.1 and 0.2%, respectively. Body weight gain (g) was increased by the feeding of diets containing 0.2% levels of MOS, but feed intake (g), feed conversion ratio (FCR) and mortality (%) did not differ significantly. Antibody (28 d), titres were significantly higher after feeding 0.1 or 0.2% MOS and antibiotic (T2) supplemented group. During d 35, the response to intra-dermally injected phyto-hemagglutinin, an index of the in vivo cell-mediated immune response, was increased in the 0.2% MOS supplemented group. Significant reduction was observed in coliforms and total plate count in cecal (28 and 42 d) and excreta (42 d) in MOS (0.1 or 0.2%) or antibiotic (T2) supplemented groups. Lactobacillus count significantly increased in cecal (28 and 42 d) and excreta (42 d) in MOS @0.1 or 0.2% supplemented groups. Thus, it can be concluded that, 0.2% MOS with basal diet has a beneficial effect for growth performance, immune response and gut health status in broiler chickens, and MOS could be a good alternative to antibiotic growth promoter.
Characterization of the degradation of dipyrone (metamizole) in expired oral pharmaceutical products by Raman spectroscopy and principal component analysis (PCA)

Abstract Stability studies are essential to ensure that a drug maintains its qualities after leaving the production line until the end of the validity date. This study aimed to identify the alterations related to shelf time in commercial formulations containing dipyrone (metamizole) and to model the shelf time by Raman spectroscopy (830 nm, 350 mW). Spectra of nine commercial medicines containing dipyrone sodium were obtained during the validity period (valid samples) and after the expiration date (overdue samples) with shelf times ranging from 46 to 62 months. The spectra were compared to identify changes due to the dipyrone degradation and develop a model to estimate the shelf time. The Raman analysis of valid and overdue samples showed peaks due to the hydrolysis-oxidation of dipyrone: a blue-shift (N feature in the difference spectrum) of the bands assigned to aromatic and pyrazole rings due to the presence of the metabolite N-methylaminoantipyrine, a decrease in peaks related to the dissociation of − SO3Na due to the hydrolysis/oxidation, and an increase in peaks associated with sodium sulfate/disulfate. A regression model based upon principal component analysis (PCA) showed a strong correlation between shelf time and the PCA variable PC2 (Pearson’s correlation coefficient r = 0.804). The study showed the feasibility of Raman spectroscopy in identifying the degradation of dipyrone sodium to characterize the shelf time and use in the quality control of commercial medicines.
On the D-Thesis

Reanimated for the contemporary literature in the writings of Quine ([15]), [16]) and Kuhn [7], the conventionalism of Duhem [2] and Poincare [12] has emerged in the last few years as one of the genuinely interesting topics in the philosophy of science. The theory in question-let us follow Griinbaum [3] in calling it the Dthesis, after its founder, Pierre Duhem-claims three things: (1) a single scientific hypothesis H is never disconfirmable in isolation from its fellow; (2) every single hypothesis H of science presupposes, explicitly or implicitly, the support of a conjunction A = A1 * A2 *. l Am of auxiliaIy assumptions or hypotheses; (3) the failure of an observational consequence of H in face of contradictory evidence disconfirms only the conjunction of H and A, not H alone-i.e. establishes only (H * A). The logical picture is as follows:
Accelerating Convergence of Sum-of-Square Stability Analysis of Coupled Differential-Difference Equations

Abstract This article aims at accelerating the convergence of Lyapunov-Krasovskii stability analysis of coupled differential-difference equations using sum-of-square formulation. Under the assumption that the single integral and double integral terms are both positive definite, a necessary and sufficient condition for the quadratic integral expression is obtained. This result is applied to the Lyapunov-Krasovskii functional and derivative conditions. The method is less conservative than the previous method with identical order of polynomials. The effectiveness of this method is illustrated by numerical examples.
Finite Element Approximation of the Transport of Reactive Solutes in Porous Media. Part 1: Error Estimates for Nonequilibrium Adsorption Processes

In this paper we analyze a fully practical piecewise linear finite element approximation involving numerical integration, backward Euler time discretization, and possibly regularization of the following degenerate parabolic system arising in a model of reactive solute transport in porous media: find $\{u(x,t),v(x,t)\}$ such that \begin{eqnarray*} &\partial_t u + \partial_t v - \Delta u =f \quad\mbox{in } \Omega \times(0,T] \qquad u=0\quad\mbox{on } \partial\Omega\times(0,T]&\\ &\partial_tv=k(\varphi(u)-v) \quad\mbox{in }\Omega\times(0,T]&\\ &u(\cdot\,,0)=g_1(\cdot)\quad v(\cdot\,,0) =g_2(\cdot)\quad\mbox{in } \Omega\subset \Real^d,\quad 1\le d\le 3& \end{eqnarray*} for given data $k\in \Real^+$, $f$, $g_1$, $g_2$ and a monotonically increasing $\varphi\in C^0(\Real)\cap C^1(-\infty,0]\cup(0,\infty)$ satisfying $\varphi(0)=0$, which is only locally Holder continuous with exponent $p\in(0,1)$ at the origin, e.g., $\varphi(s)\equiv[s]_+^p$. This lack of Lipschitz continuity at the origin limits the regularity of the unique solution $\{u,v\}$ and leads to difficulties in the finite element error analysis.
Firing patterns of single units in the prefrontal cortex and neural network models

The occurrences of high-frequency bursts of neural activity and the probability distribution of firing rates of neurons were investigated in the behaving monkey. The activity of 8 to 11 single units was recorded in parallel through six metal microelectrodes from the frontal cortical areas. High-frequency (>150 Hz) bursts of three or more spikes in succession were extremely rare, occurring at an average rate of 0.068 per second per neuron. The probability of observing a burst in one neuron was not affected by the fact that another adjacent neuron emitted a burst. Thus, if a high-frequency burst represents the ‘on’ state of a neuron, we failed to demonstrate persistent states in which a group of neurons is turned ‘on’ together. The firing rates of the neurons were usually low. The probability of a neuron firing a few (2–5) spikes within a narrow (10–100 ms) time window was very low (<0.003). The probability density of firing rates did not show any sign of inhomogeneity, thus failing to show that the neurons.
The general expression for the transition amplitude of two-photon ionization of atomic hydrogen

Two-photon ionization of atomic hydrogen with an excess photon is revisited. The non-relativistic dipole approximation and Coulomb Green function (CGF) formalism are applied. Using the CGF Sturmian expansion straightforwardly, one gets the radial transition amplitude in the form of an infinite sum over Gauss hypergeometric functions which are polynomials. It is convergent if all intermediate states are in the discrete spectrum. In the case of two-photon ionization with an excess photon, when photoionization is also possible, intermediate states are in the continuum. We performed the explicit summation over intermediate states and got a simple general expression for the radial transition amplitude in the form of a finite sum over Appell hypergeometric functions, which are not polynomials. An Appell function may be expressed as an infinite sum over Gauss functions. In the case of ionization by an excess photon, Gauss functions are transformed to give a convergent radial transition amplitude for the whole region. The generalized cross sections for two-photon above-threshold ionization of atomic hydrogen in the ground state and excited states calculated by us agree very well with results of previous calculations. Generalized cross sections for two-photon ionization of positronium in the ground state are obtained by scaling those for atomic hydrogen.
On the impulsive blocking of a vortex–jet

In this paper we consider the flow field within and around a vortex as it ‘collides’ with a thin plate at a right angle to its axis of rotation. We show that based solely on inviscid flow theory, vorticity in the core of the vortex is redistributed significantly. The main cause of this redistribution is the presence of axial flow within the vortex; we call this vortical structure which contains axial flow a vortex–jet. In this work we show that when the axial velocity within the vortex is toward the plate, vorticity is redistributed radially outward from the core resulting in a significant reduction in the axial vorticity there; the vortex is said to ‘bulge’ reflecting an increase in the nominal vortex core radius. A by-product of this interaction is that the suction peak amplitude caused by the presence of the vortex rapidly decreases and the pressure soon returns to a quasi-steady distribution. On the other hand, when the axial velocity within the vortex is directed away from the surface, the suction peak persists and the vortex core radius decreases. The numerical results were validated by comparison with an analytical solution for a sinusoidal vortex jet. Analytical solutions were also derived for the initial and final states of a pure jet; the numerical results are strongly supported by the analysis. In addition, all of these results are consistent with experiments, and their relevance to the interaction between a tip vortex and a helicopter airframe is also discussed.
Stochastic backscatter in a subgrid-scale model: Plane shear mixing layer

The traditional Smagorinsky subgrid‐scale viscosity (CSλ)2S has been supplemented by the addition of stochastic backscatter. The random acceleration is derived from a vector potential Cb‖S δt‖3/2(λ/δt)2g. Here S is the local strain rate, λ is the grid resolution length scale, δt is the time step, and g is a unit random Gaussian. It is found that values CS=0.2 for the Smagorinsky constant and Cb=0.4 for the backscatter constant give a robust calculation of the two‐dimensional shear mixing layer with the observed growth rate and with realistic emergence of random coherent eddy structures.
Vertical wind variability observed by VHF radar in the lee of the Colorado Rockies

Abstract During March 1981 the Sunset and Platteville VHF clear-air radars located in Colorado to the east of the continental divide observed vertical winds continuously over a three-week period. The vertical winds at these locations contain fluctuations with periods from a few minutes to several hours and with magnitudes ranging up to a few meters per second. The Sunset radar, which is located in the foothills, observed systematically larger vertical velocities than the vertical velocities observed by the Platteville radar, which is located on the plains, some 60 km to the east. Although periods of enhanced vertical wind activity were observed to occur at the same time at both sites, attempts to correlate vertical wind structures over the two sites in detail were generally not successful. The magnitude of vertical velocity fluctuations seen by both radars show large day-to-day variations with “active” periods alternating with “quiet” periods. An examination of upper level maps reveals that the occurrence.