Miracle-dz/UniFAR-FTUs huggingface dataset:
LARGE SAMPLE PROPERTIES OF GENERALIZED METHOD OF

IN THIS PAPER we study the large sample properties of a class of generalized method of moments (GMM) estimators which subsumes many standard econometric estimators. To motivate this class, consider an econometric model whose parameter vector we wish to estimate. The model implies a family of orthogonality conditions that embed any economic theoretical restrictions that we wish to impose or test. For example, assumptions that certain equations define projections or that particular variables are predetermined give rise to orthogonality conditions in which expected cross products of unobservable disturbances and functions of observable variables are equated to zero. Heuristically, identification requires at least as many orthogonality conditions as there are coordinates in the parameter vector to be estimated. The unobservable disturbances in the orthogonality conditions can be replaced by an equivalent expression involving the true parameter vector and the observed variables. Using the method of moments, sample estimates of the expected cross products can be computed for any element in an admissible parameter space. A GMM estimator of the true parameter vector is obtained by finding the element of the parameter space that sets linear combinations of the sample cross products as close to zero as possible. In studying strong consistency of GMM estimators, we show how to construct a class of criterion functions with minimizers that converge almost surely to the true parameter vector. The resulting estimators have the interpretation of making the sample versions of the population orthogonality conditions as close as possible to zero according to some metric or measure of distance. We use the metric to index the alternative estimators. This class of estimators includes the nonlinear instrumental variables estimators considered by, among others, Amemiya [1, 2], Jorgenson and Laffont [24], and Gallant [11]. 2 There the
Electrons and phonons in graphene : electron-phonon coupling, screening and transport in the field effect setup

Understanding the transport properties of two-dimensional crystals doped by field effect is a conceptual milestone for tomorrow's nanoelectronics. In this thesis we develop first-principles methods to investigate electron-phonon interactions, screening and phonon-limited transport in graphene. To overcome the limitations of existing plane-wave ab initio packages, originally devised for three-dimensional periodic solids, we truncate the Coulomb interaction in the third direction and isolate the 2D system from its periodic images. This is implemented in density-functional perturbation theory to calculate charge density responses and phonon spectra in a two-dimensional framework. We use those methods to develop a quantitative model of electron-phonon coupling for graphene in the field effect transistor configuration. We find that the coupling of electrons to acoustic phonons is dominated by the unscreened gauge field, which we compute with full inclusion of electron-electron interactions at the GW level. Our simulations of the static screening properties of graphene validate analytical models and reveal that the deformation potential is strongly screened, such that its contribution to acoustic phonon scattering is negligible. We find a small but finite linear coupling with out-of-plane phonons. By solving the Boltzmann transport equation we obtain the phonon-limited resistivity. Below room temperature, our results confirm the role of acoustic phonons and a 15% increase of the ab initio gauge field parameter leads to an excellent quantitative agreement with experiment. Above room-temperature, we point to the importance of the coupling with intrinsic optical phonons.
Motivic cohomology groups are isomorphic to higher chow groups in any characteristic

In this short paper we show that the motivic cohomology groups defined in [3] are isomorphic to the motivic cohomology groups defined in [1] for smooth schemes over any field. In view of [1, Proposition 12.1] this implies that motivic cohomology groups of [3] are isomorphic to higher Chow groups. This fact was previously known only under the resolution of singularities assumption. The new element in the proof is Proposition 4. The motivic complex Z(q) of weight q was defined in [3] as C∗(Ztr(G m ))[−q]. In [1, Section 8] Friedlander and Suslin defined complexes, which we will denote Z tr (q), as C∗(zequi(A , 0))[−2q] where zequi(X, 0) is the sheaf of equidimensional cycles on X of relative dimension zero. In this paper we prove the following result.
Numerical Study of Conjugate Heat Transfer of Aviation Kerosene at Supercritical Pressures

Numerical studies are conducted for three-dimensional conjugate heat transfer of aviation kerosene in engine cooling channels at supercritical pressures,with accurate calculations of thermophysical properties.The research is closely related to the regenerative cooling of supersonic combustion ramjet engines.Effects of the wall heat flux and inlet flow velocity on the heat transfer processes are carefully examined.Results indicate that fluid temperature increases sharply near the thermal entry region,because of the weak heat transfer performance of kerosene at a low inlet flow velocity.As a result,the surface temperature at the side and bottom channel walls increases significantly due to strong thermal conduction in the solid region.The applicability and accuracy of empirical heat transfer expressions in convective heat transfer of kerosene at supercritical pressures are verified.
Physicochemical and Biopharmaceutical Controllability of New Self-Assembled Fatty Acid Conjugated Leuprolide for the Enhanced Anticancer Activity

Background Leuprolide (LEU), a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH), could exert a direct inhibitory activity on the proliferation of prostate cancer cells. However, the short half-life in blood and the biopharmaceutical problem of LEU limit this anticancer activity. Purpose To improve its druggability for improving anticancer activity, the amine-group targeted LEU was conjugated with different chain lengths of saturated fatty acids (FAs). Methods LEU–fatty acid conjugates (LFCs) were synthesized by exploiting N-hydroxysuccinimidyl (NHS) conjugation chemistry. The physicochemical properties and the self-assembled behaviors of the conjugates were extensively investigated. The in vitro anticancer activity of three LFCs was extensively studied in both 2D monolayer and 3D spheroid culture models of a prostate cancer cell line, PC3. Results Three LFCs could be readily self-assembled into nanoparticles (LFNs) with a small size of around 100 nm, positive charges, and exhibited greater permeability rates compared to the same concentration of LEU, excluding LSN. The chain length of FA in conjugate was positively related to the selectivity index between cancer cells and non-cancerous cell lines. All LFCs showed a superior direct antiproliferative effect on cancer cells in the following order: LSC (98.9%) > LPC (86.7%) > LLC (75.0%) > LEU (8.9%) after repeat daily of the same dose strength of LEU for 4 days. In addition, the 3D spheroid model study indicates that all LFCs with a one-time treatment performed a long-acting inhibitory effect on tumor growth as compared to LEU after 7 days. Conclusion The conjugation of LEU with different chain lengths of FAs could provide a novel strategy to improve peptide stability and exert an additional superior direct inhibitory effect for the treatment of several hormone-responsive tumor systems using therapeutic peptides.
Combined Live Oral Priming and Intramuscular Boosting Regimen with Rotarix® and a Nanoparticle-Based Trivalent Rotavirus Vaccine Evaluated in Gnotobiotic Pig Models of G4P[6] and G1P[8] Human Rotavirus Infection

Human rotavirus (HRV) is the causative agent of severe dehydrating diarrhea in children under the age of five, resulting in up to 215,000 deaths each year. These deaths almost exclusively occur in low- and middle-income countries where vaccine efficacy is the lowest due to chronic malnutrition, gut dysbiosis, and concurrent enteric viral infection. Parenteral vaccines for HRV are particularly attractive as they avoid many of the concerns associated with currently used live oral vaccines. In this study, a two-dose intramuscular (IM) regimen of the trivalent, nanoparticle-based, nonreplicating HRV vaccine (trivalent S60-VP8*), utilizing the shell (S) domain of the capsid of norovirus as an HRV VP8* antigen display platform, was evaluated for immunogenicity and protective efficacy against P[6] and P[8] HRV using gnotobiotic pig models. A prime–boost strategy using one dose of the oral Rotarix® vaccine, followed by one dose of the IM trivalent nanoparticle vaccine was also evaluated. Both regimens were highly immunogenic in inducing serum virus neutralizing, IgG, and IgA antibodies. The two vaccine regimens failed to confer significant protection against diarrhea; however, the prime–boost regimen significantly shortened the duration of virus shedding in pigs challenged orally with the virulent Wa (G1P[8]) HRV and significantly shortened the mean duration of virus shedding, mean peak titer, and area under the curve of virus shedding after challenge with Arg (G4P[6]) HRV. Prime–boost-vaccinated pigs challenged with P[8] HRV had significantly higher P[8]-specific IgG antibody-secreting cells (ASCs) in the spleen post-challenge. Prime–boost-vaccinated pigs challenged with P[6] HRV had significantly higher numbers of P[6]- and P[8]-specific IgG ASCs in the ileum, as well as significantly higher numbers of P[8]-specific IgA ASCs in the spleen post-challenge. These results suggest the promise of and warrant further investigation into the oral priming and parenteral boosting strategy for future HRV vaccines.
The ageing immune system as a potential target of senolytics

Abstract Ageing leads to a sharp decline in immune function, precipitating the development of inflammatory conditions. The combined impact of these processes renders older individuals at greater risk of inflammatory and immune-related diseases, such as cancer and infections. This is compounded by reduced efficacy in interventions aiming to limit disease impact, for instance vaccines being less effective in elderly populations. This state of diminished cellular function is driven by cellular senescence, a process where cells undergo stable growth arrest following exposure to stressful stimuli, and the associated pro-inflammatory secretory phenotype. Removing harmful senescent cells (SnCs) using senolytic therapies is an emerging field holding promise for patient benefit. Current senolytics have been developed either to specifically target SnCs, or repurposed from cancer therapies or vaccination protocols. Herein, we discuss recent developments in senolytic therapies, focusing on how senolytics could be used to combat the age-associated diminution of the immune system. In particular, exploring how these drugs may be used to promote immunity in the elderly, and highlighting recent trials of senolytics in idiopathic pulmonary fibrosis and diabetic kidney disease. Novel immunotherapeutic approaches including chimeric antigen receptor T-cells or monoclonal antibodies targeting SnCs are being investigated to combat the shortcomings of current senolytics and their adverse effects. The flexible nature of senolytic treatment modalities and their efficacy in safely removing harmful SnCs could have great potential to promote healthy immune function in ageing populations.
Dose Escalation of Oropharyngeal Cancer: Long-Time Follow-Up and Side Effects

Simple Summary In head and neck cancer, local recurrences are unfortunately common. A more intense local treatment, such as an increased radiation dose to the primary tumour, could potentially prevent some of these recurrencies. Previous studies have not shown an increased risk of side effects with a higher radiotherapy dose. However, the follow-up time in these studies is sometimes limited, and late side effects may then be missed. In our study with a relatively long patient follow-up, we compared survival and side effects in two groups with 215 patients in each group, where one group was treated with standard dose radiotherapy and the other group was treated with a higher dose of radiotherapy. In this study, we found that certain severe side effects are more common after higher doses of radiotherapy compared to after treatment with standard dose radiotherapy. Abstract Previous studies on dose-escalated radiotherapy in head and neck cancer have shown mixed results, and it is not established which patients would benefit from dose escalation. Further, while dose escalation does not appear to increase late toxicity, this needs to be confirmed with longer follow-up. In this study, we analysed treatment outcome and toxicity in 215 patients with oropharyngeal cancer treated with dose-escalated radiotherapy (>72 Gy, EQD2, α/β = 10 Gy, boost by brachytherapy or simultaneous integrated boost) and a matched cohort of 215 patients treated with standard dose external-beam radiotherapy (68 Gy) between 2011 and 2018 at our institution. The 5-year overall survival (OS) was 77.8% (72.4–83.6) and 73.7% (67.8–80.1) in the dose-escalated and standard dose group, respectively (p = 0.24). Median follow-up was 78.1 (49.2–98.4) and 60.2 (38.9–89.4) months in the dose-escalated and standard dose groups, respectively. Grade ≥3 osteoradionecrosis (ORN) and late dysphagia were more common in the dose-escalated group compared to the standard dose group, with 19 (8.8%) vs. 4 (1.9%) patients developing grade ≥3 ORN (p = 0.001), and 39 (18.1%) vs. 21 (9.8%) patients developing grade ≥3 dysphagia (p = 0.01). No predictive factors to help select patients for dose-escalated radiotherapy were found. However, the remarkably good OS in the dose-escalated cohort, despite a predominance of advanced tumour stages, encourages further attempts to identify such factors.
Wave propagation in a two-temperature fiber-reinforced magneto-thermoelastic medium with three-phase-lag model

A general model of equations of the two-temperature theory of generalized thermoelasticity is applied to study the wave propagation in a fiber-reinforced magneto-thermoelastic medium in the context of the three-phase-lag model and Green-Naghdi theory without energy dissipation. The material is a homogeneous isotropic elastic half-space. The exact expression of the displacement components, force stresses, thermodynamic temperature and conductive temperature is obtained by using normal mode analysis. The variations of the considered variables with the horizontal distance are illustrated graphically. Comparisons are made with the results of the two theories in the absence and presence of a magnetic field as well as a two-temperature parameter. A comparison is also made between the results of the two theories in the absence and presence of reinforcement.
The Effect Of Smart Tourism Technologies, Memorable Tourism Experiences, And Tourist Satisfactions On Traveller Loyalty (Study On Traveller Users Of The Tiket.Com App)

The purpose of this study is to find out whether smart tourism technologies have an influence on tourist loyalty, to find out whether memorable tourism experiences have an influence on tourist loyalty, to find out whether tourist stratification has an influence on tourist loyalty, and to find out whether smart tourism technologies, memorable tourism experiences, and tourist stratification together affect loyalty tourist. The methods used in this study are descriptive types of research and quantitative approaches. The data collection technique is to distribute questionnaires to 100 respondents. The data analysis technique used is multiple regression analysis. The results obtained in this study are that there is a positive and significant influence between Smart Tourism Technologies on Tourist Loyalty of Tiket.Com App Users. There is a positive and significant impact between the Memorable Tourism Experience and the Traveller Loyalty of Tiket.Com App Users. There is a positive and significant impact between Tourist Satisfactions and Traveller Loyalty of Tiket.Com App Users. And simultaneously there is a positive and significant influence between smart tourism technologies (X1), memorable tourism experience (X2), and tourist satisfactions (X3) on the Loyalty of Tiket.Com App User Travellers. The level of relationship between the variables of smart tourism technologies (X1), memorable tourism experience (X2), and tourist satisfactions (X3) with the variable of tourist loyalty (Y) has a fairly strong level of relationship.
SIMULATION OF SMOKE DISPERSION AND TEMPERATURE DISTRIBUTION ON KEBON MELATI SUB-DISTRICT FIRE USING COMPUTATIONAL FLUID DYNAMICS

: Kebon Melati sub-district is one of the densely populated areas in the capital city of Jakarta which is prone to fires. In the last twenty years, there have been three cases of fire mostly caused by electrical short circuits. Those fire cause fire smoke dispersion and fire propagation as secondary impact. The aim of this research is to analyze fire smoke dispersion pattern and temperature distribution pattern around hotspots, also to analyze potential area that has to encounter those secondary impacts, henceforth the side that can be used as an evacuation route can be determined. Google Maps, AutoCAD 2015, Revit 2015, Autodesk Flow Design 2015, and Fire Dynamics Simulator are used in this research. Autodesk Flow Design 2015 simulation result wind flow in the west side of Kebon Melati sub-district is more stable than in the east and middle side which have wind flow turbulence as effect of wind flow separation by skyscraper buildings. On the outer west side of Kebon Melati sub-district, wind velocity increase up to 9 m/s as effect of wind flow separation by skyscraper buildings. Fire Dynamics Simulator simulation result, in 30 s simulation with 10.000 kW/m 2 Heat Release Rate per unit Area, fire smoke disperse up to 1.440 m in South direction. The South Side has the greatest potential for reduced visibility, fire smoke pollution, and fire propagation. The sides that can be used as evacuation route is the Westside and the Middle side which has more stable wind flow than the East side.
The role of site-2-proteases in bacteria: a review on physiology, virulence, and therapeutic potential

Abstract Site-2-proteases are a class of intramembrane proteases involved in regulated intramembrane proteolysis. Regulated intramembrane proteolysis is a highly conserved signaling mechanism that commonly involves sequential digestion of an anti-sigma factor by a site-1- and site-2-protease in response to external stimuli, resulting in an adaptive transcriptional response. Variation of this signaling cascade continues to emerge as the role of site-2-proteases in bacteria continues to be explored. Site-2-proteases are highly conserved among bacteria and play a key role in multiple processes, including iron uptake, stress response, and pheromone production. Additionally, an increasing number of site-2-proteases have been found to play a pivotal role in the virulence properties of multiple human pathogens, such as alginate production in Pseudomonas aeruginosa, toxin production in Vibrio cholerae, resistance to lysozyme in enterococci and antimicrobials in several Bacillus spp, and cell-envelope lipid composition in Mycobacterium tuberculosis. The prominent role of site-2-proteases in bacterial pathogenicity highlights the potential of site-2-proteases as novel targets for therapeutic intervention. In this review, we summarize the role of site-2-proteases in bacterial physiology and virulence, as well as evaluate the therapeutic potential of site-2-proteases.
Caring the Sharing Apps – Exploration of the Factors Affecting User Satisfaction with Sharing Economy Apps

Abstract Sharing economy-based services are more prevalent in contemporary society, especially after the covid-19 pandemic. However, from the user’s perspective, it is still unclear what factors define the success of sharing economy-based apps. To address this issue, we conducted a study using an integrated theoretical framework that incorporated cognitive load theory, social network theory, and theory of planned behavior. 448 samples were collected from three tourist destinations in India to test the model. The results showed that mobile app user interface, interaction, and social networking would positively impact user satisfaction with sharing economy-based apps. User satisfaction also leads to recommendation and continuance intention. The study findings have several implications and recommendations for future studies on sharing economy apps.
A numerical criterion for uniruledness

An n-dimensional variety X over an algebraically closed field k is said to be uniruled if there exist an (n 1)-dimensional k-variety W and a dominant rational map f: P' x W -* X. X is called separably uniruled if f is a separable map (i.e. k(P' x W) is a finite separable extension of k(X) via f). If X is uniniled, then there exists a rational curve passing through a general k-valued point of X, and the converse is true (by the countability of the components of the Hilbert scheme) provided that the ground field k is uncountable. Uniruled varieties are of importance in the classification of varieties; it is conjectured that in characteristic 0 uniruledness is equivalent to K = Xc. This article gives a numerical criterion for a projective variety to be uniruled:
Weather Sentiment Index and Stock Return Predictability: Evidence from China

ABSTRACT This paper introduces a weather-related sentiment (mood) index (WSI) for the Chinese stock market based on precipitation and temperature data with the PLS method. We find that the WSI is negatively correlated with the equity market and has strong predictive power that is far greater than that of other market and macroeconomic variables. The predictability also holds under the characteristic-mimicking portfolios. The driving force of the WSI’s predictive power appears to stem from its ability to predict future cash flow, which reflects investor preference.
Rheology of Broken Rice-Foxtail Millet-Maize Flour Blends Related to Extrusion Cooking

Rheological properties of the various flours from the broken rice, foxtail millet and maize used during extrusion conditions were investigated for pasting properties and dynamic oscillation using Rheometer. Results pointed out that each of the different flour might be utilized for specific applications in food processing. In addition, the functional properties of individual flours were measured. The swelling power of broken rice flour showed the highest values, indicated that the viscoelastic properties of pastes were dependent on the swelled starch–protein complex granules and the formation of new cross-links in the network. All formulation flours exhibited variable pasting behavior, among different temperatures and formulations at 90°C and 20:60:20 had the highest peak viscosity 6741 MPa.s and final viscosity 6842 MPa.s and was found to be more effective than other temperature and formulation combinations. Viscosity decreased with the increase of temperature and formulation combinations. The storage modulus was invariably higher than loss modulus at all stages during heating, holding and cooling of the sample, showing that the paste has a tendency to behave like weak gel. G´ was the most primary dynamic rheological parameter that reflected rheological properties, G´ represented the elastic properties of rice starch paste.