Miracle-dz/UniFAR-FTUs huggingface dataset:
Motion perception tasks as potential correlates to driving difficulty in the elderly

Changes in the demographics indicates that the population older than 65 is on the rise because of the aging of the ‘baby boom’ generation. This aging trend and driving related accident statistics reveal the need for procedures and tests that would assess the driving ability of older adults and predict whether they would be safe or unsafe drivers. Literature shows that an attention based test called the useful field of view (UFOV) was a significant predictor of accident rates compared to any other visual function tests. The present study evaluates a qualitative trend on using motion perception tasks as a potential visual perceptual correlates in screening elderly drivers who might have difficulty in driving. Data was collected from 15 older subjects with a mean age of 71. Motion perception tasks included—speed discrimination with radial and lamellar motion, time to collision using prediction motion and estimating direction of heading. A motion index score was calculated which was indicative of performance on all of the above-mentioned motion tasks. Scores on visual attention was assessed using UFOV. A driving habit questionnaire was also administered for a self report on the driving difficulties and accident rates. A qualitative trend based on frequency distributions show that thresholds on the motion perception tasks are successful in identifying subjects who reported to have had difficulty in certain aspects of driving and had accidents. Correlation between UFOV and motion index scores was not significant indicating that probably different aspects of visual information processing that are crucial to driving behaviour are being tapped by these two paradigms. UFOV and motion perception tasks together can be a better predictor for identifying at risk or safe drivers than just using either one of them.
Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase

Tramadol is a useful analgesic which acts as a serotonin and noradrenaline reuptake inhibitor in addition to μ-opioid receptor agonist. Cytoplasmic serotonin modulates the small GTPase activity through serotonylation, which is closely related to the human platelet activation. We recently reported that the combination of subthreshold collagen and CXCL12 synergistically activates human platelets. We herein investigated the effect and the mechanism of tramadol on the synergistic effect. Tramadol attenuated the synergistically stimulated platelet aggregation (300 μM of tramadol, 64.3% decrease, p<0.05). Not morphine or reboxetine, but duloxetine, fluvoxamine and sertraline attenuated the synergistic effect of the combination on the platelet aggregation (30 μM of fluvoxamine, 67.3% decrease, p<0.05; 30 μM of sertraline, 67.8% decrease, p<0.05). The geranylgeranyltransferase inhibitor GGTI-286 attenuated the aggregation of synergistically stimulated platelet (50 μM of GGTI-286, 80.8% decrease, p<0.05), in which GTP-binding Rac was increased. The Rac1-GEF interaction inhibitor NSC23766 suppressed the platelet activation and the phosphorylation of p38 MAPK and HSP27 induced by the combination of collagen and CXCL12. Tramadol and fluvoxamine almost completely attenuated the levels of GTP-binding Rac and the phosphorylation of both p38 MAPK and HSP27 stimulated by the combination. Suppression of the platelet aggregation after the duloxetine administration was observed in 2 of 5 patients in pain clinic. These results suggest that tramadol negatively regulates the combination of subthreshold collagen and CXCL12-induced platelet activation via Rac upstream of p38 MAPK.
Clustering and turbulence modulation in particle laden shear flows

Turbulent fluctuations induce the commonplace phenomenology on the transport of small inertial particles known as clustering. Particles spread disuniformly and form aggregates where their local concentration is much higher than it is in nearby rarefaction regions, the voids, where in extreme cases not even a single particle can be found. The underlying physics has been exhaustively analyzed in statistically homogeneous and isotropic flows under the so called oneway coupling regime, i.e. in conditions where the momentum exchange between the carrier fluid and the disperse phase is negligible. Recently it has been shown that the addition of a mean flow might have dramatic effects on the disperse phase, i.e. the mean flow, through its large scale anisotropy, induces a preferential orientation of the clusters. Due to inertial effects, their directionality can even increase in the smallest scales, contrary to the expectation based on the isotropy recovery behavior of velocity fluctuations. This finding opens new issues in presence of large mass loads, when the momentum exchange between the two phases becomes significant and the back-reaction of the particles on the carrier flow cannot be neglected. These aspects are discussed here by addressing direct numerical simulation data of particle laden homogeneous shear flow in the two-way coupling regime. Consistently with previous findings we observe an overall depletion of turbulent fluctuations. In particular, particles with order Kolmogorov scale relaxation time induce the energy depletion of the classical inertial scales and the amplitude increase of the smallest ones where the particle back-reaction pumps energy into the turbulent eddies increasing their energy content. We find that increased mass loads result in the substantial broadening of the energy co-spectrum thereby extending the range of scales driven by anisotropic production mechanisms. This is due to the clusters which form the spatial support of the back-reaction field and give rise to a highly anisotropic forcing active down to the smallest scales.
The Steady Linear Response of a Spherical Atmosphere to Thermal and Orographic Forcing

Abstract Motivated by some results from barotropic models, a linearized steady-state five-layer baroclinic model is used to study the response of a spherical atmosphere to thermal and orographic forcing. At low levels the significant perturbations are confined to the neighborhood of the source and for midlatitude thermal forcing these perturbations are crucially dependent on the vertical distribution of the source. In the upper troposphere the sources generate wavetrains which are very similar to those given by barotropic models. For a low-latitude source, long wavelengths propagate strongly polewards as well as eastwards. Shorter wavelengths are trapped equatorward of the poleward flank of the jet, resulting in a split of the wave-trains at this latitude. Using reasonable dissipation magnitudes, the easiest way to produce an appreciable response in middle and high latitudes is by subtropical forcing. These results suggest an explanation for the shapes of patterns described in observational studies. The t.
Same day discharge for robot‐assisted radical prostatectomy: a prospective cohort study documenting an Australian approach

The introduction of robotic surgical systems has significantly impacted urological surgery, arguably more so than other surgical disciplines. The focus of our study was length of hospital stay ‐ patients have traditionally been discharged day 1 post‐robot‐assisted radical prostatectomy (RARP), however, during the ongoing COVID‐19 pandemic and consequential resource limitations, our centre has facilitated a cohort of same‐day discharges with initial success.
SHP-1 tyrosine phosphatase binding to c-Src kinase phosphor-dependent conformations: A comparative structural framework

SHP-1 is a cytosolic tyrosine phosphatase that is primarily expressed in hematopoietic cells. It acts as a negative regulator of numerous signaling pathways and controls multiple cellular functions involved in cancer pathogenesis. This study describes the binding preferences of SHP-1 (pY536) to c-Srcopen (pY416) and c-Srcclose (pY527) through in silico approaches. Molecular dynamics simulation analysis revealed more conformational changes in c-Srcclose upon binding to SHP-1, as compared to its active/open conformation that is stabilized by the cooperative binding of the C-SH2 domain and C-terminal tail of SHP-1 to c-Src SH2 and KD. In contrast, c-Srcclose and SHP-1 interaction is mediated by PTP domain-specific WPD-loop (WPDXGXP) and Q-loop (QTXXQYXF) binding to c-Srcclose C-terminal tail residues. The dynamic correlation analysis demonstrated a positive correlation for SHP-1 PTP with KD, SH3, and the C-terminal tail of c-Srcclose. In the case of the c-Srcopen-SHP-1 complex, SH3 and SH2 domains of c-Srcopen were correlated to C-SH2 and the C-terminal tail of SHP-1. Our findings reveal that SHP1-dependent c-Src activation through dephosphorylation relies on the conformational shift in the inhibitory C-terminal tail that may ease the recruitment of the N-SH2 domain to phosphotyrosine residue, resulting in the relieving of the PTP domain. Collectively, this study delineates the intermolecular interaction paradigm and underlying conformational readjustments in SHP-1 due to binding with the c-Src active and inactive state. This study will largely help in devising novel therapeutic strategies for targeting cancer development.
Diagnosis and management of extramedullary plasmacytoma in nasal cavity: Clinical experience and literature review

Nasal extramedullary plasmacytoma (EMP) is a rare plasma cell tumor that occurs in the soft tissue of the nasal cavity, and its imaging characteristics are still unclear. The purpose of this study was to investigate the clinical features, imaging findings, treatment, survival analysis, and prognosis of nasal EMP, and to provide a systematic review of the patients we treated and the published literature. A 45-year-old female patient who presented with epistaxis with nasal obstruction was recommended for magnetic resonance imaging to assess the nature of the lesion. On magnetic resonance imaging, abnormal signal shadow can be seen in the right nasal cavity. Diffusion weighted imaging showed signal of the lesion was significantly limited, presenting high signal, with a low apparent dispersion coefficient, and the lesion was significantly enhanced on contrast-enhanced scan. Combined with the clinical manifestations of the patient, who was initially considered to have a hemangioma. She underwent endoscopic nasal surgery under general anesthesia to remove the mass, and the final pathology confirmed it was EMP. However, the final pathology confirmed EMP. Five months later, the patient came to our hospital for follow-up and underwent fluorine-18-fluorodeoxyglucose/positron emission tomography/computed tomography scan, which showed no recurrence of the lesion and no transformation of multiple myeloma. The nasal EMP imaging findings were mostly soft tissue masses with uniform density or signal, which were significantly enhanced by enhancement scan, high signal on diffusion weighted imaging and low signal on apparent dispersion coefficient. Immunohistochemical staining for CD38, CD138, and CD79a was positive in most of the cases evaluated, while CD20 and CD10 were negative. The absence of dilated features, infiltrative features and the presence of significant contrast enhancement may be relatively specific imaging findings of nasal EMP. The prognosis of nasal EMP is good, and recurrence, metastasis, and transformation into multiple myeloma are rare. Because the lesions are sensitive to radiotherapy, surgical resection combined with radiotherapy is a more effective treatment.
Relative Productivity of For-Profit Hospitals: A Big or a Little Deal?

This study asks: Does the empirical evidence support the conclusion that for-profit (FP) hospitals are more productive or efficient than private not-for-profit (NFP) hospitals or non-federal public (PUB) hospitals? Alternative theories of NFP behavior are described. Our review of individual empirical hospital studies of quality, service mix, community benefit, and cost/efficiency in the United States published since 2000 indicates that no systematic difference exists in cost/efficiency, provision of uncompensated care, and quality of care. But FPs are more likely to provide profitable services, higher service intensity, have lower shares of uninsured and Medicaid patients, and are more responsive to external financial incentives. That FP hospitals are not more efficient runs counter to property rights theory, but their relative responsiveness to financial incentives supports it. There is little evidence that FP market presence changes NFP behaviors. Observed differences between FP and NFP hospitals are mostly a “little deal. ”
Alcohol septal ablation in hypertrophic cardiomyopathy: For which patients?

Percutaneous and surgical therapies for septal reduction for hypertrophic cardiomyopathy have been going head‐to‐head for the past 20 years with similar outcomes and mortality rates, although contemporary myectomy seems to materialize its superiority. However, on closer analysis, the external validity of studies advocating myectomy does not translate to all centres. The aim of this review was to examine the most recent data on septal reduction therapy and to attempt to phenotype the appropriate patient for each of the two treatments. The key to similar low mortality rates between ventricular septal myectomy and alcohol septal ablation appears to be proper patient selection performed in high volume clinical environments. Furthermore, we analyse the role of mavacampten (the recently approved cardiac myosin inhibitor) in replacing or complementing the two septal reduction therapies.
Validation of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) Scale by Dim Light Melatonin Onset in Healthy Young Adults

Understanding the biological rhythms that influence young adult health is vital because the combination of biological changes and a circadian phase delay lead to young adults being at high risk of circadian misalignment. We have previously established a self-rating of biological rhythm disorder for adolescents (SBRDA). However, we did not externally validate the SBRDA against objective measures of biological rhythms such as dim light melatonin onset (DLMO)—the gold standard of the endogenous circadian phase. The purpose of this study was to verify the effectiveness of SBRDA in identifying individuals with biological rhythm disorders. Our participants were 42 (47.2%) boys and 47 (52.8%) girls with an average age of 18.5 ± 1.2 years. Saliva samples were collected from 4 h before bed time to 2 h after sleep every 60 min in a dim-light (<50 lx) laboratory environment. Biological rhythm parameters were assessed using questionnaires, including SBRDA, MEQ, and MCTQ. The mean DLMO time (h) was 22.2 ± 1.9. The DLMO correlated significantly with the SBRDA score (r = 0.33, p < 0.001), MEQ score (r = -0.24, p < 0.05), and MSFsc (r = 0.26, p < 0.05). ROC curve analysis showed that SBRDA was of diagnostic value for biological rhythm disorder (p < 0.05). Our observations demonstrate that SBRDA, which is consistent with MEQ and MCTQ, can be used to reflect endogenous circadian rhythm disorders in young adults. Exposure to dim light may activate melatonin secretion and lead to an earlier peak in young adults with biological rhythm disorder.
Molecular epidemiology of respiratory syncytial virus in children with acute respiratory illnesses in Africa: A systematic review and meta-analysis

Background Globally, the respiratory syncytial virus (RSV) is the most common etiologic agent of acute respiratory illnesses in children. However, its burden has not been well addressed in developing countries. We aimed to estimate the molecular epidemiology of RSV in children less than 18 years of age with acute respiratory infections in Africa by conducting a systematic review and meta-analysis. Methods We systematically searched PubMed, Scopus, CINAHL, and Global Index Medicus databases to identify studies published from January 1, 2002, to April 27, 2022, following the PRISMA 2020 guideline. We assessed the study quality using the Joanna Brigg’s Institute (JBI) critical appraisal checklists. We conducted a qualitative synthesis by describing the characteristics of included studies and performed the quantitative synthesis with random effects model using STATA-14. We checked for heterogeneity with Q statistics, quantified by I2, and determined the prediction interval. We performed subgroup analyses to explain the sources of heterogeneity and assessed publication biases by funnel plots augmented with Egger’s test. Results Eighty-eight studies with 105 139 participants were included in the review. The overall pooled prevalence of RSV in children <18 years of age was 23% (95% confidence interval (CI) = 20, 25%). Considerable heterogeneity was present across the included studies. The adjusted prediction interval was found to be 19%-27%. Heterogeneities were explained by subgroups analyses. The highest prevalence of RSV was found among inpatients, 28% (95% CI = 25, 31%) compared with inpatients/outpatients and outpatients, with statistically significant differences (P < 0.01). The RSV estimate was also highest among those with acute lower respiratory tract illnesses (ALRTIs), 28% (95% CI = 25, 31%) compared with acute upper respiratory tract illnesses (AURTIs) and both acute upper/lower respiratory manifestations, with statistically different prevalence (P < 0.01). RSV infection estimates in each sub-region of Africa were statistically different (P < 0.01). There were no statistically significant differences in RSV infections by designs, specimen types, and specimen conditions, despite them contributing to heterogeneity. Conclusions We found a high prevalence of RSV in pediatric populations with acute respiratory tract illnesses in Africa, highlighting that the prevention and control of RSV infections in children deserve more attention. Registration PROSPERO CRD42022327054
The Use and Structure of Emergency Nurses’ Triage Narrative Data: Scoping Review

Background Emergency departments use triage to ensure that patients with the highest level of acuity receive care quickly and safely. Triage is typically a nursing process that is documented as structured and unstructured (free text) data. Free-text triage narratives have been studied for specific conditions but never reviewed in a comprehensive manner. Objective The objective of this paper was to identify and map the academic literature that examines triage narratives. The paper described the types of research conducted, identified gaps in the research, and determined where additional review may be warranted. Methods We conducted a scoping review of unstructured triage narratives. We mapped the literature, described the use of triage narrative data, examined the information available on the form and structure of narratives, highlighted similarities among publications, and identified opportunities for future research. Results We screened 18,074 studies published between 1990 and 2022 in CINAHL, MEDLINE, Embase, Cochrane, and ProQuest Central. We identified 0.53% (96/18,074) of studies that directly examined the use of triage nurses’ narratives. More than 12 million visits were made to 2438 emergency departments included in the review. In total, 82% (79/96) of these studies were conducted in the United States (43/96, 45%), Australia (31/96, 32%), or Canada (5/96, 5%). Triage narratives were used for research and case identification, as input variables for predictive modeling, and for quality improvement. Overall, 31% (30/96) of the studies offered a description of the triage narrative, including a list of the keywords used (27/96, 28%) or more fulsome descriptions (such as word counts, character counts, abbreviation, etc; 7/96, 7%). We found limited use of reporting guidelines (8/96, 8%). Conclusions The breadth of the identified studies suggests that there is widespread routine collection and research use of triage narrative data. Despite the use of triage narratives as a source of data in studies, the narratives and nurses who generate them are poorly described in the literature, and data reporting is inconsistent. Additional research is needed to describe the structure of triage narratives, determine the best use of triage narratives, and improve the consistent use of triage-specific data reporting guidelines. International Registered Report Identifier (IRRID) RR2-10.1136/bmjopen-2021-055132
A leading bibliometric author does not have a dominant contribution to research based on the CJAL score: Bibliometric analysis

Background: A total of 22,367 bibliometric articles have been indexed by Web of Science (WoS). The most significant contribution to the field has not yet been identified through bibliometric analysis. A comparison of individual research achievements (IRAs) and trend analysis of article citations are required after extracting bibliometric articles. The study aimed to confirm whether the leading author has a dominant RA and which articles are worth reading for readers using trend analysis. Methods: We identified authors with at least 100 articles related to bibliometrics in the WoS core collection. A total of 399 articles were collected to cluster author collaborations. Co-word analysis and chord diagrams were used to match chief authors in clusters with Keywords Plus in WoS core collection. The category, journal impact factor, authorship, and L-index (CJAL) score and the absolute advantage coefficient (AAC) were used to compare IRAs and identify the leading author who dominated the field significantly beyond the next 2 authors. In addition to network charts and chord diagrams, 4 visualizations were used to report study results, including a Sankey diagram, a dot plot, a temporal trend graph, and a radar plot. The temporal bubble graph was used to select articles that deserve to be read. Results: The top 3 authors were Lutz Bornmann, Yuh-Shan Ho, and Giovanni Abramo, with CJAL scores of 176.22, 176.02, and 112.06, respectively, from Germany, Italy, and Taiwan. Based on the weak dominance coefficient (AAC = 0.20 < 0.70), it is evident that the leading bibliometric author has no such significant power beyond the next 2 leading authors in IRAs. A trend analysis of the last 4 years was used to illustrate the 2 articles that deserve to be read. Conclusion: Three leading authors were identified through a co-word analysis of bibliometrics. There was no evidence of an author who possessed a dominant position due to a lower AAC on the leading author. The CJAL score and the AAC can be applied to many bibliographical studies in the future rather than being limited to bibliometric studies that evaluate the leading authors in a field, as we did in this study.
Lymphangiomatosis presented with melena and chylous ascites: A case report

Introduction: Lymphangioma, a rare benign tumor of the lymphatic system, is called lymphangiomatosis when it involves >1 organ, which is more rarely complicated with thoracic obstruction, the relationship between them remains unclear. With the development of enteroscopy, clinicians know more about small intestinal lymphangioma and attempt to treat it through enteroscopic injection sclerotherapy(EIS). Patient concerns: A 59-year-old male firstly manifested with gastrointestinal bleeding after a gastric perforation, who was diagnosed with lymphangiomatosis by balloon-assisted enteroscopy and abdomen CT showing >1 organ with multiple cysts besides the small intestine. The patient received an EIS, then the melena disappeared. Surprisingly he came back because of refractory ascites confirmed to be chylous by chemical tests 7 months later. Diagnosis: Lymphangiography could not determine the location of lymphatic leakage, Ultrasonography showed stenosis of the left cervical part of the thoracic duct. Intervention: On the condition that medical treatment is ineffective, thoracic duct exploration and lysis of fibrous adhesion were performed. Outcomes: Ascites significantly reduced at last. Lessons: Lymphangiomatosis is the malformation of the lymphatic system involving multiple organs, it has a possibility to be associated with thoracic obstruction. Capsule endoscopy and enteroscopy are effective methods to diagnose small intestinal lymphangioma, and EIS is an effective therapy.