Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Polypropylene Drainage Pipe

The purpose of this study was to conduct a field evaluation of polypropylene pipes in order to assess their potential suitability for drainage applications. The specific objectives were (1) to document the product handling during installation, and (2) to evaluate the in-situ performance under service conditions. The Virginia Department of Transportation (VDOT) selected five test locations on low-volume rural roads in Albemarle County where the field evaluation would occur. Installation of the pipes was carried out by a VDOT maintenance crew. In all cases, polypropylene drainage pipes replaced the existing corrugated metal and concrete pipes that had reached the end of their service life. No material testing of any kind was carried out on the pipes. It was understood that the limited scope of the study would not result in any conclusive assessment regarding the particular product’s potential long-term performance. The dualand triple-wall plastic pipes with nominal diameters of 30 and 48 in were supplied by ADS, Inc. The installation process was documented, and periodic field observations were conducted during the subsequent 1 year of service. As part of the evaluation, cross-sectional measurements were conducted at 2.5-ft intervals on all installed pipes. The results indicated that after 1 year of service, the maximum deformations of all pipes were less than 5 percent, satisfying current VDOT post-installation inspection requirements. No signs of crushing, buckling, or material degradation were detected. The results of the study indicate that polypropylene pipe offers a number of potential benefits when used in drainage applications. The durability of a plastic pipe must be resolved adequately in order to facilitate widespread product usage. In the case of polypropylene pipe, the issue of degradation attributable to material oxidation is extremely important. For many transportation projects, the owner must have a reasonable degree of assurance that the material will perform satisfactorily for at least 50 years. Fortunately, test methods for the durability assessment are currently available. It is possible that as users become more familiar with polypropylene pipe, they will increasingly regard it as a viable alternative in terms of life cycle costs. The product appears to lend itself to further evaluation as a promising innovative design. The report provides recommendations regarding the potential future acceptance protocol for polypropylene pipes on culvert and storm sewer projects. The recommendations include a durability assessment by an independent laboratory and a field verification of performance on the VDOT network.
PENGEMBANGAN MODEL PELATIHAN SOFT-SKILLS PADA SISWA SEKOLAH MENENGAH PERTAMA NEGERI (SMPN) DI KOTA MATARAM

Abstrak : Penelitian dan pengembangan ini bertujuan menghasilkan model pelatihan soft - skill khususnya keterampilan komunikasi dan kendali emosi siswa sekolah menengah pertama negeri (SMPN) di kota Mataram. Metode penelitian dan pengembangan dilakukan melalui tiga tahap dari sepuluh langkah Borg & Gall yaitu, (1) penelitian awal (analisis kebutuhan), (2) pengembangan model pelatihan, (3) uji coba dan evaluasi model. Hasil penelitian menunjukkan bahwa pengembangan model pelatihan soft - skill menghasilkan pedoman pelatihan untuk konselor dan siswa, serta materi pelatihan soft - skill yang memenuhi kriteria akseptabel dari kegunaan, kemanfaatan, dan kelayakan. Disamping itu hasil penelitian menunjukkan pula bahwa terdapat perbedaan skor antara pr e-test dan p ost-test keterampilan mengelola emosi dari tidak terampil menjadi sangat trampil, dan keterampilan komunikasi dari tidak terampil menjadi cukup terampil. Abstract: Research and development is aimed to produce soft-skills training models especially in communication skills and emotional control student junior high school (SMP) in Mataram city. Research and development method is carried out through three stages from the ten steps of Borg & Gall, they are; (1) the preliminary research (needs analysis), (2) the development of training model, (3) Model evaluation and try out. The results show that the development of soft-skills training model develop training manual for counselors and students, as well as soft-skills training materials that meet acceptable criteria of usability, usefulness and feasibility. Besides, the results showed also that there is a difference in scores between pre-test and post-test in skills at managing emotions from unskilled to be very skilled, and communication skills from unskilled become quite skilled. Permalink/DOI: http://dx.doi. org/10.17977/um001v1i22016p047
Experiments on the WavePiston, Wave Energy Converter

— This paper analyses the performance of a new Wave Energy Converter (WEC) of the Oscillating Water Column type (OWC), named WavePiston. This near-shore floating device is composed of plates (i.e. energy collectors) sliding around a cylinder, that is placed perpendicular to the shore. Tests in the wave basin at Aalborg University allowed to investigate power production in the North Sea typical wave climate, with varying design parameters such as plate dimensions and their mutual distance. The power produced per meter by each collector is about the 5% of the available wave power. Experimental results and survivability considerations suggest that the WavePiston would be particularly suited for installations in milder seas. An example application is therefore presented in the Mediterranean Sea, off-shore the island of Sicily. In this case, each collector harvests the 10% of the available wave power. In order to allow the extension of the experimental dataset, an analytical model, based on mass-spring-damper system concept, is under development. The model is calibrated in order to represent the laboratory results for regular waves.
The Therapeutic Effect and Clinical Outcome of Immune Checkpoint Inhibitors on Bone Metastasis in Advanced Non-Small-Cell Lung Cancer

Introduction In advanced non-small-cell lung cancer (NSCLC), immune checkpoint inhibitors (ICIs) have been reported a better treatment outcome on primary lesions, however, the therapeutic effect on bone metastases has not been clarified. This study investigates the therapeutic effect of ICIs on bone metastases in advanced NSCLC. Methods The data of patients with advanced NSCLC, treated with ICIs from 2016 to 2019 at our hospital, were analyzed. The therapeutic effects of ICIs on primary lung and metastatic bone lesions, concomitant use of bone modifying agents (BMA), treatment outcomes, and frequency of immune-related adverse events (irAEs) and skeletal-related events (SREs) were investigated. Results A total of 29 patients were included (19 men and 10 women; mean age, 64.2 years). Among the ICIs, pembrolizumab was the most used (55.2%), and concomitant use of BMA was prevalent in 21 patients (zoledronic acid=1, denosumab=20). The therapeutic effect was partial response (PR) in 10.3% (n=3) on primary lung lesions by RECIST 1.1, complete response (CR) in 6.9% (n=2) and PR in 17.2% (n=5) on bone metastatic lesions by MDA criteria. ICIs suppressed the progression of bone metastasis in 21 cases (72.4%). All patients in CR and PR were treated with pembrolizumab and denosumab. SREs and irAEs were developed in 3.4% (n=1) and 20.7% (n=6), respectively. The median survival time after treatment with ICIs was 11.0 months. Concomitant therapy with ICIs and denosumab significantly prolonged the overall survival compared to ICI-only therapy (16.0 months vs. 2.5 months, p<0.01). Conclusions This study showed that treatment with ICIs may successfully suppress the progression of bone metastasis in advanced NSCLC. Pembrolizumab with denosumab had the highest therapeutic effect on both primary lung lesions and bone metastases. Systemic treatment with this combination and conservative treatment of bone metastasis could be one of the options in the treatment of advanced NSCLC.
Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis

Background Atopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and Tregs in peripheral blood of patients with AD. Methods A comprehensive literature search was performed in PubMed, Embase, China National Knowledge Internet, and Wan-fang Data from the day of inception of this study to July 2021. Two authors independently extracted the data, which were pooled and calculated using Stata software version 15. Results A total of eight studies met the inclusion criteria. Compared with control group, patients with AD had an increased proportion of Th22 cells [weighted mean difference (WMD) = 2.07, 95% CI (1.33, 2.81), p < 0.001], Th17 cells [WMD = 1.04, 95% CI [0.66, 1.43], p < 0.001], IL-17 [WMD = 17.56, 95% CI (11.1, 24.03), p < 0.001], and a decreased proportion of Tregs [WMD = −2.49, 95% CI (−2.93, −2.05), p < 0.001] in peripheral blood. The subgroup analysis showed that patients with higher disease severity had higher levels of Th22 [mild: WMD = 1.33, 95% CI (1.24, 1.41), p < 0.001; moderate: WMD = 1.41, 95% CI (1.36, 1.54), p < 0.001; severe: WMD = 3.46, 95% CI (3.34, 2.81), p < 0.001] and lower levels of Tregs [mild: WMD = −1.43, 95% CI (−1.75, −1.11), p < 0.001; moderate: WMD = −2.16, 95% CI (−2.46, −1.86), p < 0.001; severe: WMD = −2.96, 95% CI (−3.25, −2.67), p < 0.001] in peripheral blood compared to healthy controls. Conclusion The random effect model of the meta-analysis showed patients with AD had an increased proportion of Th22 cells, Th17 cells, and IL-17, whereas a decreased proportion of Tregs was found in peripheral blood. The results demonstrated that Th22 cells, Th17 cells, IL-17, and Tregs may be involved in the pathogenic mechanisms of AD.
All the Routes for Laparoscopic Liver Segment VIII Resection: A Comprehensive Review of Surgical Techniques

Liver surgery is highly demanding for anatomical, physiological and technical reasons, and minimally invasive approaches have been implemented at a slower rate. Today, laparoscopic liver resection is a standard of care in many occasions, yet specific operations remain particularly challenging and generally performed in open surgery. In particular, SVIII resection may be considered one of the most difficult due to anatomical characteristics including its sub-diaphragmatic position, the deep-lying Glissonean pedicle and the close contact with the inferior vena cava and right and middle hepatic veins. Many techniques have risen to overcome technical difficulties, and today laparoscopic SVIII resection has been demonstrated to be feasible. This review provides a complete picture of current approaches, focusing on all techniques reported so far with critical appraisal of each, discussing and explaining benefits and pitfalls.
Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls

Objective This study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC). Methods Using flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated. Results At baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p<0.05) compared to HC. There were no differences between NAEB and EA. After 1 month of inhaled corticosteroid (ICS) treatment, NAEB patients showed a significant improvement in cough symptoms, but the attenuation of sputum HPC and EoP levels was not significant. Conclusions NAEB patients have increased airway levels of HPCs and EoPs. One-month treatment with ICS did not fully suppress the level of EoPs in NAEB. Controlling in situ airway differentiation of EoPs may control airway eosinophilia and provide long-term resolution of symptoms in NAEB.
Dural Immune Cells, CGRP, and Migraine

Migraine is the most common neurological disorder in the world, affecting 12% of the population. Migraine involves the central nervous system, trigeminal nerves and meninges. Recent advances have shown that targeting calcitonin gene-related peptide (CGRP) through either antibodies or small molecule receptor antagonists is effective at reducing episodic and chronic migraine episodes, but these therapeutics are not effective in all patients. This suggests that migraine does not have a singular molecular cause but is likely due to dysregulated physiology of multiple mechanisms. An often-overlooked part of migraine is the potential involvement of the immune system. Clinical studies have shown that migraine patients may have dysregulation in their immune system, with abnormal plasma cytokine levels either during the attack or at baseline. In addition, those who are immunocompromised appear to be at a higher risk of migraine-like disorders. A recent study showed that migraine caused changes to transcription of immune genes in the blood, even following treatment with sumatriptan. The dura mater is densely packed with macrophages, mast and dendritic cells, and they have been found to associate with meningeal blood vessels and trigeminal afferent endings. Recent work in mice shows activation and morphological changes of these cells in rodents following the migraine trigger cortical spreading depression. Importantly, each of these immune cell types can respond directly to CGRP. Since immune cells make up a large portion of the dura, have functional responses to CGRP, and interact with trigeminal afferents, CGRP actions on the dural immune system are likely to play key roles in migraine.
Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome With Partial Least Squares Discriminant Analysis: Relevance of Blood Extracellular Vesicles

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic disease characterized by long-lasting persistent debilitating widespread fatigue and post-exertional malaise, remains diagnosed by clinical criteria. Our group and others have identified differentially expressed miRNA profiles in the blood of patients. However, their diagnostic power individually or in combinations seems limited. A Partial Least Squares-Discriminant Analysis (PLS-DA) model initially based on 817 variables: two demographic, 34 blood analytic, 136 PBMC miRNAs, 639 Extracellular Vesicle (EV) miRNAs, and six EV features, selected an optimal number of five components, and a subset of 32 regressors showing statistically significant discriminant power. The presence of four EV-features (size and z-values of EVs prepared with or without proteinase K treatment) among the 32 regressors, suggested that blood vesicles carry relevant disease information. To further explore the features of ME/CFS EVs, we subjected them to Raman micro-spectroscopic analysis, identifying carotenoid peaks as ME/CFS fingerprints, possibly due to erythrocyte deficiencies. Although PLS-DA analysis showed limited capacity of Raman fingerprints for diagnosis (AUC = 0.7067), Raman data served to refine the number of PBMC miRNAs from our previous model still ensuring a perfect classification of subjects (AUC=1). Further investigations to evaluate model performance in extended cohorts of patients, to identify the precise ME/CFS EV components detected by Raman and to reveal their functional significance in the disease are warranted.
Auditory Cognitive Training Improves Brain Plasticity in Healthy Older Adults: Evidence From a Randomized Controlled Trial

The number of older adults is increasing globally. Aging is associated with cognitive and sensory decline. Additionally, declined auditory performance and cognitive function affect the quality of life of older adults. Therefore, it is important to develop an intervention method to improve both auditory and cognitive performances. The current study aimed to investigate the beneficial effects of auditory and cognitive training on auditory ability and cognitive functions in healthy older adults. Fifty healthy older adults were randomly divided into four training groups—an auditory-cognitive training group (AC training; n = 13), an auditory training group (A training; n = 13), a cognitive training group (C training; n = 14), and an active control group (n = 12). During the training period, we reduced the sound intensity level in AC and A training groups and increase training task difficulty in AC, A, and C training groups based on participants’ performance. Cognitive function measures [digit-cancelation test (D-CAT); logical memory (LM); digit span (DS)], auditory measures [pure-tone audiometry (PTA)], and magnetic resonance imaging (MRI) scans were performed before and after the training periods. We found three key findings. First, the AC training group showed difference between other training groups (A, C, and active control training groups) in regional gray matter volume (rGMV) in the right dorsolateral prefrontal cortex, the left inferior temporal gyrus (L. ITG), the left superior frontal gyrus, the left orbitofrontal cortex, the right cerebellum (lobule 7 Crus 1). Second, the auditory training factor groups (ATFGs, the AC and A training groups) improved auditory measures and increased the rGMV and functional connectivity (FC) in the left temporal pole compared to the non-ATFGs (the C training group and active control group). Third, the cognitive training factor groups (CTFGs; the AC and C training groups) showed statistically significant improvement in cognitive performances in LM and D-CAT compared to the non-CTFGs (the A training group and active control group). Therefore, the auditory training factor and cognitive training factor would be useful in enhancing the quality of life of older adults. The current AC training study, the plasticity of the brain structure was observed after 4 weeks of training.
Directional DBS of the Fornix in Alzheimer’s Disease Achieves Long-Term Benefits: A Case Report

Background Current treatments for Alzheimer’s disease (AD) modulate global neurotransmission but are neither specific nor anatomically directed. Tailored stimulation of target nuclei will increase treatment efficacy while reducing side effects. We report the results of the first directional deep brain stimulation (dDBS) surgery and treatment of a patient with AD in an attempt to slow the progression of the disease in a woman with multi-domain, amnestic cognitive status. Methods We aimed to assess the safety of dDBS in patients with AD using the fornix as stimulation target (primary objective) and the clinical impact of the stimulation (secondary objective). In a registered clinical trial, a female patient aged 81 years with a 2-year history of cognitive decline and diagnoses of AD underwent a bilateral dDBS surgery targeting the fornix. Stimulation parameters were set between 3.9 and 7.5 mA, 90 μs, 130 Hz for 24 months, controlling stimulation effects by 18F-fluoro-2-deoxy-D-glucose (18F-FDG) scans (baseline, 12 and 24 months), magnetoencephalography (MEG) and clinical/neuropsychological assessment (baseline, 6, 12, 18, and 24 months). Results There were no important complications related to the procedure. In general terms, the patient showed cognitive fluctuations over the period, related to attention and executive function patterns, with no meaningful changes in any other cognitive functions, as is shown in the clinical dementia rating scale (CDR = 1) scores over the 24 months. Such stability in neuropsychological scores corresponds to the stability of the brain metabolic function, seen in PET scans. The MEG studies described low functional connectivity at baseline and a subsequent increase in the number of significant connections, mainly in the theta band, at 12 months. Conclusion The dDBS stimulation in the fornix seems to be a safe treatment for patients in the first stage of AD. Effects on cognition seem to be mild to moderate during the first months of stimulation and return to baseline levels after 24 months, except for verbal fluency. Clinical Trial Registration [https://clinicaltrials.gov/ct2/show/NCT03290274], identifier [NCT03290274].
A Network Analysis of the Relationships Between Behavioral Inhibition/Activation Systems and Problematic Mobile Phone Use

Background It is of great concern to society that individuals can be vulnerable to problematic mobile phone use (PMPU). However, there are a few studies in the field evaluating associations between behavioral inhibition/activation systems (BIS/BAS) and PMPU, and the results have been inconsistent. This study aimed to explore the relationships between BIS/BAS and PMPU by network analysis. Methods A total of 891 young adults participated in the study. BIS/BAS and PMPU were assessed by using the behavioral inhibition and activation systems scale and smartphone application-based addiction scale, respectively. The structure of the BIS/BAS-PMPU network was characterized using “strength,” “closeness” and “betweenness” as centrality indices. Edge-weight accuracy and centrality stability were tested using a bootstrap procedure. Results The network analysis showed that “mood modification,” “tolerance” and “withdrawal symptoms” had high centrality. In addition, the positive connection between BIS and “mood modification” or “tolerance” and between BAS-fun seeking and “mood modification” or “conflict” were also shown in the BIS/BAS-PMPU network. Conclusion These findings shed light on the central and bridge components between the BIS/BAS and PMPU communities, providing new evidence relevant to potential mechanisms that account for how high-BIS or high-BAS individuals develop PMPU, and inspiring component-based PMPU prevention or interventions.
How Do Different Reanalysis Radiation Datasets Perform in West Qilian Mountains?

Solar radiation plays an important role in the cryospheric water cycle, especially in alpine regions. This study presents an evaluation of the Modern-Era Retrospective analysis for Research and Applications 2 (MERRA2), ERA5, High Asia Refined analysis version 2 (HAR v2), JRA-55, and National Centers for Environmental Prediction/Climate Forecast System Reanalysis datasets at different time scales by comparing observed datasets from July 2010 to December 2015 at 4,550 m in the Laohugou Basin. In terms of shortwave radiation, ERA5 performs significantly better than the other reanalysis radiation datasets. For downward shortwave radiation, HAR v2 performs better than ERA5 on only two timescales, 3 months and half-year, with mean absolute errors (MAEs) of 13.28 and 7.96 w/m2. The upward shortwave radiation, ERA5, outperforms the other reanalysis datasets on all 12 timescales. For downward longwave radiation, ERA5 also performs significantly better, with only MERRA2 outperforming ERA5 on the daily scale and annual scale, with R 2, bias, root mean square error, and MAE of 0.6, 0.95, −9.51 w/m2, −9.41 w/m2, 34.98 w/m2, 9.46 w/m2, and 27.52 w/m2, 9.41 w/m2, respectively. In the upward longwave radiation, HAR v2 performs better than the other reanalysis datasets on all timescales, except for ERA5, which has a better R 2 of 0.92 on the annual scale. All the reanalysis datasets can show the variation trend of the four radiation parameters in different seasons and achieve a better performance in winter. Therefore, ERA5 is recommended for regions without shortwave radiation observations, and HAR v2 and ERA5 are recommended for longwave radiation simulations. Although there are obvious shortcomings in the reanalysis radiation datasets, they still provide important supplementary information for research in high-altitude areas, where the observed datasets are too sparse.