Miracle-dz/UniFAR-FTUs huggingface dataset:
Employees’ CSR attributions and pro-environmental behaviors in the hotel industry: the key role of female supervisors

ABSTRACT This study suggests that employees’ pro-environmental behaviors are determined by their attributions regarding the reasons why hotels engage in corporate socially responsible initiatives. Furthermore, the role of supervisors’ corporate social responsibility (CSR) perceptions in shaping frontline employees’ CSR attributions is studied. Finally, we examine whether the impact of supervisor’s CSR perceptions on employee attributions differs according to the supervisor’s gender. The results showed the influence of substantive CSR attributions on pro-environmental behaviors, as well as the influence of supervisors’ CSR perceptions on employees’ substantive CSR attributions. It is also found that when the supervisor is a woman, the effect of her CSR perceptions on employees’ CSR substantive attributions was stronger. Additionally, women’s CSR perception also significantly influenced employees’ CRS symbolic attributions, although to a lesser extent. These findings have important theoretical and practical implications to promote sustainable economic growth and reduce the environmental impact on the hotel industry.
Strong Population Genetic Structure of Phrynocephalus versicolor in Mongolia

Abstract: We examined the phylogenetic relationships and evolutionary divergence of Phrynocephalus versicolor Strauch 1876, as well as the genetic diversity and population structure in Mongolia using mtDNA variation. Phrynocephalus is one of the most diverse genera within the Agamidae family, with confusing or controversial taxonomy. This resulted in several independent suggestions for subspecies designations within Phrynocephalus versicolor. As the most dominant and abundant reptilian species in the Mongolian Gobi Desert, Phrynocephalus versicolor is ecologically important within the food chain of the ecological system it inhabits. We used 77 samples from 9 populations of P. versicolor in central and southern Mongolia. We amplified and sequenced 522–base pair (bp) –long fragment of the ND2 gene and recorded moderate levels of sequence diversity (Hd = 0.74 ± 0.023, π = 0.035 defined by 97 polymorphic sites). We conducted phylogenetic analyses using of Bayesian inference, maximum likelihood, and median-joining (MJ) network analysis that resulted in four well-supported clades (A, B, C, D) among our Mongolian samples. All of these clades, except Clade A, were population specific. The genetic distance values (mean Fst = 0.768), and analysis of molecular variance (AMOVA) also showed greater genetic distances between these clades. We ran a time-calibrated phylogenetic analysis using a strict molecular clock model with a single fossil calibration. The estimated divergence times in this study were comparable with previous findings, for example, 1.8 million years ago (mya) (1.31–2.94) for the node (Bayesian posterior probability [BPP] > 1.0 and bootstrap > 98) from which Clade A and B originated. In conclusion, our findings showed that there are at least three genetically distinct subspecies, namely P. v. versicolor, P. v. kulagini, and P. v. hispidus, with one previously unknown clade/lineage.
Gender on the agenda: Media framing of women and women of color in the 2020 U.S. presidential election

The results of this article propose three primary findings: first, the news media perpetuates and creates new stereotypes for women and women of color who run for political office; second, female journalists disproportionately write news articles about female candidates compared to their male counterparts; and finally, images of women in online news stories appear to be “vanishing,” with news articles supplementing media elements with videos and infographics.
miR-500a-3p is a Potential Prognostic Biomarker in Hepatocellular Carcinoma

Purpose miR-500a-3p has been extensively reported to be implicated in the development and progression in several human cancer types. This study aimed to investigate the diagnostic and prognostic significance of miR-500a-3p as a biomarker in hepatocellular carcinoma (HCC). Methods miR-500a-3p expression was evaluated by in situ hybridization (ISH) and real-time PCR in 10 adjacent normal tissues (ANT), 21 liver fibrosis tissues, and 110 HCC tissues. Statistical analysis was used to investigate the correlation of miR-500a-3p expression with clinicopathological features in HCC patients. Kaplan–Meier survival analysis was performed to evaluate the prognostic significance of miR-500a-3p in overall survival and recurrence-free survival in HCC patients. Results In this study, we found that expression levels of miR-500a-3p were enhanced in HCC tissues. High miR-500a-3p levels were positively correlated with multiple clinicopathological features, including advanced clinical stage, distant metastatic status, increased AFP levels and poor tumor differentiation degree. More importantly, high miR-500a-3p levels predicted poor overall survival and early recurrence in HCC patients. Finally, a strong and positive correlation of miR-500a-3p mRNA expression with ISH staining scores was observed in clinical HCC tissues. Conclusion Our findings suggest that miR-500a-3p might be used as a novel biomarker to facilitate early diagnosis and predict prognosis in HCC patients.
Gender and Sex-Related Differences in Normal Tissue Effects Induced by Platinum Compounds

Gender medicine in the field of oncology is an under-researched area, despite the existing evidence towards gender-dependent response to therapy and treatment-induced adverse effects. Oncological treatment aims to fulfil its main goal of achieving high tumour control by also protecting normal tissue from acute or chronic damage. Chemotherapy is an important component of cancer treatment, with a large number of drugs being currently in clinical use. Cisplatin is one of the most commonly employed chemotherapeutic agents, used either as a sole drug or in combination with other agents. Cisplatin-induced toxicities are well documented, and they include nephrotoxicity, neurotoxicity, gastrointestinal toxicity, ototoxicity, just to name the most frequent ones. Some of these toxicities have short-term sequelae, while others are irreversible. Furthermore, research showed that there is a strong gender-dependent aspect of side effects caused by the administration of cisplatin. While evidence towards sex differences in animal models is substantial, clinical studies considering sex/gender as a variable factor are limited. This work summarises the current knowledge on sex/gender-related side effects induced by platinum compounds and highlights the gaps in research that require more attention to open new therapeutic possibilities and preventative measures to alleviate normal tissue toxicity and increase patients’ quality of life in both males and females.
Skin Wound Tension Reduction Device Combined with Ablative Fractional Carbon Dioxide Laser to Reduce Scar Formation After Excision of Pediatric Facial Skin Lesions: A Prospective Cohort Study

Purpose To investigate the efficacy of skin wound tension reduction device (SWTRD) combined with ablative fractional carbon dioxide laser (CO2-AFL) for the prevention of scar formation following the excision of facial cutaneous lesions in children. Methods Patients undergoing surgical excision of facial cutaneous lesions in our hospital between May 2019 and April 2021 were enrolled. After the excision of facial cutaneous lesions and based on the personal intents and conditions, patients were assigned to undergo SWTRD combined with CO2-AFL. Outcome evaluations were as follows: defect size, incision width, scar width, the Vancouver Scar Scale (VSS) and University of North Carolina 4P Scar Scale (UNC4P). Results A total of 25 pediatric patients (mean age, 9.88 years) were enrolled in the study. Following the treatment of SWTRD+CO2-AFL, scar widths were relatively narrow and the appearance of the incision scars was significantly improved. A significant reduction in the patient-reported UNC4P scores at 6 months (3, 1–4) was observed when compared with that at 2 months (0, 0–1) after surgery (p<0.001). A similar reduction in the VSS scar scale was also evident (6 months: 1, 0.75–2.5 vs 2 months: 6.5–8.5; p<0.001). Conclusion Combined SWTRD and CO2-AFL treatment effectively modulates the scar formation after the incision is healed and resulting in preventing scar widening, leading to the improvement of scar appearance, reduction in wound pain and pruritus and its overall prognosis.
Patient and provider experiences with CBT-I administered in-person or via telemedicine: A randomized non-inferiority trial

Abstract Cognitive behavioral therapy for insomnia (CBT-I) is an effective treatment in adults. However, access to care is limited. One potential solution is telemedicine. Though synchronous video-based telemedicine CBT-I has been shown to be non-inferior to in-person treatment, there is no study to date that evaluates patient and provider experiences with video-based treatment. Our study team evaluated patient and provider perceptions of CBT-I delivered via telemedicine versus an in-person format. As part of a larger randomized control trial, we interviewed patients and providers in both arms of the study (in-person and via telemedicine). 20 minute interviews were conducted over the phone and were transcribed and coded to identify themes. While patients shared initial concerns about telemedicine CBT-I, including privacy and technological issues, they were satisfied with the approach and had similar experiences as the patients receiving in-person treatment. Providers shared concerns about challenges establishing a strong therapeutic alliance, patient engagement, and accountability in CBT-I, but felt these did not interfere with their overall ability to deliver care. Patients and providers were satisfied with CBT-I treatment delivered via telemedicine when compared to those being treated in-person. Patients in both arms noted that virtual care could increase access and provide convenience.
Problem Technology Use, Academic Performance, and School Connectedness among Adolescents

Background: Little is known about the association between problem technology use in adolescents and school-related outcomes. The purpose of this study was to determine the prevalence of problem technology use and examine its association with academic performance and school connectedness in a sample of students across Ontario, Canada. Methods: Self-reported data from a sample of 4837 students in grades 9 to 12 (mean age: 15.9 years; 49.5% females) were cross-sectionally analyzed. Ordered logistic regression models were adjusted for important covariates. Results: We found that 35.8% of students used their screen device for at least 5 h a day and about 18.6% had moderate-to-serious symptoms of problem technology use, a prevalence that was higher in females (22.4%) than males (14.9%). Heavy technology use was differentially associated with lower academic performance and lower levels of school connectedness in males and females. Having moderate-to-serious symptoms of problem technology use was associated with lower academic performance among males (AOR = 0.68, 95% CI = 0.53–0.87) and females (AOR = 0.66, 95% CI = 0.52–0.84). It was also associated with less school connectedness in both males (AOR = 0.65, 95% CI = 0.50–0.86) and females (AOR = 0.63, 95% CI = 0.51–0.78). Conclusion: Excessive use and problem technology use are highly prevalent among secondary school students, and they are associated with lower academic performance and lower levels of school connectedness.
Influence of Drought Stress on Growth and Essential Oil Yield of Ocimum Species

A pot experiment was conducted to assess the effect of drought stress on growth and secondary compound accumulation of Ocimum species, in a semi-controlled greenhouse during the year 2020. The experiment was performed as a factorial that was based on a randomized complete design with three species of basil namely O. basilicum ‘Genovese’, O. x africanum, and O. americanum, and three levels of water supply (70, 50, and 30% soil water capacity-SWC) that were replicated twice. The results revealed that severe drought conditions (30% SWC) significantly lowered the relative water content and, as a consequence, plants were shorter, narrower in the canopy, and produced smaller leaves which, in turn, resulted in a 50% fresh and dry herb yield loss. Furthermore, severe drought stress negatively affected the essential oil content (except O. x africanum where no change was seen), essential oil yield, and the antioxidant capacity. However, slight enhancements of glandular hair density were observed in the drought treatment than in the control. Regardless of the soil water capacity variation, the major compound of the essential oil and total polyphenol content remained unchanged. Besides drought, morphological and chemical variations were also detected among the Ocimum species. Sweet basil cultivar Genovese produced the maximum biomass (344.7 g/plant) whereas O. x africanum accumulated higher essential oil (2.79%). The major compounds that were identified were linalool in O. basilicum; 1, 8-cineole, and camphor in O. x africanum; and O. americanum had more neral and geranial. In conclusion, a higher water supply is recommended for higher biomass and essential oil yield production in the tested basil species.
Obesity Reshapes the Microbial Population Structure along the Gut-Liver-Lung Axis in Mice

The microbiome is emerging as a major player in tissue homeostasis in health and disease. Gut microbiome dysbiosis correlates with several autoimmune and metabolic diseases, while high-fat diets and ensuing obesity are known to affect the complexity and diversity of the microbiome, thus modulating pathophysiology. Moreover, the existence of a gut-liver microbial axis has been proposed, which may extend to the lung. In this context, we systematically compared the microbiomes of the gut, liver, and lung of mice fed a high-fat diet to those of littermates fed a matched control diet. We carried out deep sequencing of seven hypervariable regions of the 16S rRNA microbial gene to examine microbial diversity in the tissues of interest. Comparison of the local microbiomes indicated that lung tissue has the least diverse microbiome under healthy conditions, while microbial diversity in the healthy liver clustered closer to the gut. Obesity increased microbial complexity in all three tissues, with lung microbial diversity being the most modified. Obesity promoted the expansion of Firmicutes along the gut-liver-lung axis, highlighting staphylococcus as a possible pathologic link between obesity and systemic pathophysiology, especially in the lungs.
Herbicidal-cum-Integrated Approach of Weed Management in Spring Planted Sugarcane

Conventional practice (three hoeings and weeding at 15, 30 and 45 days after planting) recorded significantly higher cane yield as compared to all other treatments. Pre-emergence application of either metribuzin or atrazine both at 1.0 kg ha−1 followed by trash mulching at 3.5 t ha−1 in between cane rows at 60 DAP provided effective control of weeds giving significantly lower weed dry matter with higher cane yield as compared to pre- and post-emergence application of 2,4-D, diuron, pendimethalene each at 1.0 kg ha−1 and oxyfluorfen 0.3 kg ha−1 which were statistically at par among themselves. The net profit was highest with conventional practice (Rs. 30310) followed by metribuzin+trash mulching (Rs. 28272) and atrazine+trash mulching (Rs. 27122).
Experimental Evolution of Multidrug Resistance in Neurospora crassa under Antifungal Azole Stress

Multidrug resistance, defined as the resistance to multiple drugs in different categories, has been an increasing serious problem. Limited antifungal drugs and the rapid emergence of antifungal resistance prompt a thorough understanding of how the occurrence of multidrug resistance develops and which mechanisms are involved. In this study, experimental evolution was performed under single-azole-drug stress with the model filamentous fungus Neurospora crassa. By about 30 weeks of continuous growth on agar plates containing ketoconazole or voriconazole with weekly transfer, four evolved multidrug-resistant strains 30thK1, 30thK2, 26thV1, and 24thV2 were obtained. Compared to the ancestral strain, all four strains increased resistance not only to commonly used azoles, including ketoconazole, voriconazole, itraconazole, fluconazole, and triadimefon, but also to antifungal drugs in other categories, including terbinafine (allylamine), amorolfine (morpholine), amphotericin B (polyene), polyoxin B (chitin synthesis inhibitor), and carbendazim (β-tubulin inhibitor). After 8 weeks of growth on agar plates without antifungal drugs with weekly transfer, these evolved strains still displayed multidrug-resistant phenotype, suggesting the multidrug resistance could be stably inherited. Transcriptional measurement of drug target genes and drug transporter genes and deletion analysis of the efflux pump gene cdr4 in the evolved strains suggest that overexpression of cdr4 played a major role in the resistance mechanisms for azoles and terbinafine in the evolved strains, particularly for 30thK2 and 26thV1, and evolved drug-resistant strains had less intracellular ketoconazole accumulation and less disruption of ergosterol accumulations under ketoconazole stress compared to wild type. Mutations specifically present in evolved drug-resistant strains were identified by genome re-sequencing, and drug susceptibility test of knockout mutants for most of mutated genes suggests that mutations in 16 genes, functionally novel in drug resistance, potentially contribute to multidrug resistance in evolved strains.
Blood–Brain Barrier Disruption Mediated by FFA1 Receptor—Evidence Using Miniscope

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), obtained from diet and dietary supplements, have been tested in clinical trials for the prevention or treatment of several diseases. n-3 PUFAs exert their effects by activation of free fatty acid (FFA) receptors. FFA1 receptor, expressed in the pancreas and brain, is activated by medium- to long-chain fatty acids. Despite some beneficial effects on cognition, the effects of n-3 PUFAs on the blood–brain barrier (BBB) are not clearly understood. We examined the effects of FFA1 activation on BBB permeability in vitro, using rat brain microvascular endothelial cells (RBMVEC), and in vivo, by assessing Evans Blue extravasation and by performing live imaging of brain microcirculation in adult rats. AMG837, a synthetic FFA1 agonist, produced a dose-dependent decrease in RBMVEC monolayer resistance assessed with Electric Cell–Substrate Impedance Sensing (ECIS); the effect was attenuated by the FFA1 antagonist, GW1100. Immunofluorescence studies revealed that AMG837 produced a disruption in tight and adherens junction proteins. AMG837 increased Evans Blue content in the rat brain in a dose-dependent manner. Live imaging studies of rat brain microcirculation with miniaturized fluorescence microscopy (miniscope) showed that AMG837 increased extravasation of sodium fluorescein. Taken together, our results demonstrate that FFA1 receptor activation reduced RBMVEC barrier function and produced a transient increase in BBB permeability.
Chasing Cane Toads: Assessing Locomotory Differences in Toads from Core and Edge Populations in Florida

Abstract: Cane Toads (Rhinella marina) are an invasive species introduced to southern Florida, USA, and populations have spread northward through the state. Populations established near expanding edges of their distributions are predicted to have greater endurance, an indicator of dispersal capability, than longer established populations. To assess endurance, we collected Cane Toads from a northern (edge) and southern (core) population in Florida, placed them into a track, and prodded them to hop. The number of prods (taps), hops, and time spent hopping were recorded, along with the total distance each toad moved on the track. Edge population toads were less willing to move and did not travel as far in the track as those from the core population. To further evaluate endurance, we placed an additional set of toads inside a treadmill, where movement was required to maintain equilibrium. Toads moved on the treadmill until reaching exhaustion. We measured blood lactate levels from each toad upon exhaustion and during a 3-h recovery period. After the treadmill trials, there was no population effect on the distances traveled by toads. There was also no population effect on lactate levels of toads when reaching exhaustion or during recovery. Overall, Cane Toads from our sampled northern edge population showed no differences in endurance compared to those sampled from the southern population in this study. This finding may indicate that further dispersal is limited in the northernmost populations of the Cane Toad range in Florida. Furthermore, the reluctance of Cane Toads to move in the track trials may indicate that selective pressures differ for edge populations in Florida.
Disiplin Kerja terhadap Kinerja Karyawan

Kinerja karyawan belum sesuai dengan yang diharapkan, hal ini disebabkan adanya karyawan front office dan F&B yang saat bekerja tidak berada ditempat, pergi keluar hotel dan baru kembali saat akan mengambil absen pulang. Penelitian ini bertujuan untuk menganalisis displin kerja terhadap kinerja karyawan. Pendekatan asosiatif kausal dengan bentuk penelitian kauntitatif adalah jenis penelitian yang dipakai pada penelitian ini. Teknik pengambilan sampel menggunakan total sampling dengan jumlah karyawan sebanyak 30 orang yang dijadikan sebagai populasi dan sampel pada penelitian ini. Jenis data yang digunakan dalam penelitian yaitu data primer melalui penyebaran kuesioner dan data sekunder dari absensi dan performance review karyawan. Metode pengumpulan data menggunakan angket. Teknik analisis data dengan uji persyaratan analisis dan juga pengujian hipotesis dengan teknik analisis regresi linear sederhana dan koefisien determinan dengan bantuan SPPS 20.00. Hasil penelitian menunjukkan displin kerja di kategori baik (50%), kinerja karyawan di kategori tinggi (63,33%.). Uji regresi linear sederhana sebesar 12,494 nilai signifikan sig 0,007 < 0,05. Nilai R square 0,229. 22,9% disiplin kerja dapat mempengaruhi kinerja karyawan dan 77,1% selebihnya yang mempengaruhi kinerja karyawan adalah faktor lain. Nilai t sebesar 007dengan nilai signifikan 0,007 < 0,05 sehingga diperoleh adanya pengaruh yang signifikan antar kedua variabel. Pengujian koefisien regresi nilai 0,585 yang nilai signifikannya 0,007 < 0,05 dimana setiap satuan disiplin kerja dapat menaikkan 0,585 satuan kinerja karyawan. Maka, disiplin kerja berpengaruh terhadap kinerja karyawan.