Miracle-dz/UniFAR-FTUs huggingface dataset:
Neurologically asymptomatic patients frequently present cerebral injuries during malignant hypertension: a MRI study

Supplemental Digital Content is available in the text Background: Acute and diffuse microvascular damage characterizes malignant hypertension (MHT), the deadliest form of hypertension (HTN). Although its ophthalmological, renal and cardiological repercussions are well known, brain involvement is considered rare with few descriptions, although it is one of the main causes of death. We hypothesized that brain MRI abnormalities are common in MHT, even in patients without objective neurological signs. Method: We analyzed retrospectively the brain MRI of patients admitted for acute MHT between 2008 and 2018 in Bordeaux University Hospital, regardless of their neurological status. A trained operator analyzed every brain MRI, looking for posterior reversible encephalopathy syndrome (PRES), ischemic stroke, intracerebral hematoma (ICH) and microangiopathy markers. We included 58 patients without neurological signs, 66% were men, and mean age was 45.6 ± 11.3 years. Results: Brain MRI were normal in 26% of patients but we found at least one acute abnormality on brain MRI in 29% and an Small Vessel Disease score (SVD score) of two or higher in 52%. In patients with neurological signs, these findings were 9, 53 and 70%, respectively. A PRES was found in 16% of asymptomatic patients and 31% had an ischemic stroke and/or a cerebral hematoma. Conclusion: PRES, recent hematoma, ischemic stroke and severe cerebral microangiopathy are common findings in MHT patients without neurological signs on admission. The impact of these findings on patient management, and their cerebrovascular and cognitive prognostic value, should be established. Brain MRI might need to become systematic in patients suffering from MHT episodes.
Hypertension awareness, treatment, and control in adults with CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study.

BACKGROUND A low rate of blood pressure control has been reported in patients with chronic kidney disease (CKD). These data were derived from population-based samples with a low rate of CKD awareness. STUDY DESIGN Cross-sectional. SETTING & PARTICIPANTS Data from the baseline visit of the Chronic Renal Insufficiency Cohort (CRIC) Study (n = 3,612) were analyzed. Participants with an estimated glomerular filtration rate of 20-70 mL/min/1.73 m(2) were identified from physician offices and review of laboratory databases. OUTCOMES Prevalence and awareness of hypertension, treatment patterns, control rates, and factors associated with hypertension control. MEASUREMENTS Following a standardized protocol, blood pressure was measured 3 times by trained staff, and hypertension was defined as systolic blood pressure > or =140 mm Hg and/or diastolic blood pressure > or =90 mm Hg and/or self-reported antihypertensive medication use. Patients' awareness and treatment of hypertension were defined using self-report, and 2 levels of hypertension control were evaluated: systolic/diastolic blood pressure <140/90 and <130/80 mm Hg. RESULTS The prevalence of hypertension was 85.7%, and 98.9% of CRIC participants were aware of this diagnosis and 98.3% were treated with medications, whereas 67.1% and 46.1% had hypertension controlled to <140/90 and <130/80 mm Hg, respectively. Of CRIC participants with hypertension, 15%, 25%, 26%, and 32% were using 1, 2, 3, and > or =4 antihypertensive medications, respectively. After multivariable adjustment, older patients, blacks, and those with higher urinary albumin excretion were less likely, whereas participants using angiotensin-converting enzyme inhibitors and angiotensin receptor blockers were more likely to have controlled their hypertension to <140/90 and <130/80 mm Hg. LIMITATIONS Data were derived from a single study visit. CONCLUSIONS Despite almost universal hypertension awareness and treatment in this cohort of patients with CKD, rates of hypertension control were suboptimal.
Augmented Hill-Climb increases reinforcement learning 1 efficiency for language-based de novo molecule 2 generation 3

: A plethora of AI-based techniques now exists to conduct de novo molecule 14 generation that can devise molecules conditioned towards a particular endpoint in the 15 context of drug design. One popular approach is using reinforcement learning to update a 16 recurrent neural network or language-based de novo molecule generator. However, 17 reinforcement learning can be inefficient, sometimes requiring up to 10 5 molecules to be 18 sampled to optimize more complex objectives, which poses a limitation when using 19 computationally expensive scoring functions like docking or computer-aided synthesis 20 planning models. In this work, we propose a reinforcement learning strategy called 21 Augmented Hill-Climb based on a simple, hypothesis-driven hybrid between REINVENT and 22 Hill-Climb that improves sample-efficiency by addressing the limitations of both currently 23
HEMATOPOIESIS AND STEM CELLS The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice

stem cells and cancer; however, its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is over-expressed in acute myeloid leukemias. Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrowincreased peripheral blood T cellsand, following secondarytransplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential. ( Blood . 2015;125(13):2075-2078)
Seasonal trend analysis of published ground-based and TOMS total ozone data through 1991

A seasonal trend analysis of published Dobson (including stations' newly revised and Brewer-simulated Dobson) total ozone data through 1991 from a network of 56 stations has been performed, using three different data periods. The trend results for the longest data period 1964–1991 indicate substantial negative trends in ozone in the higher northern latitudes during the winter and spring seasons, some evidence of negative trend in the higher southern latitudes (30°S–55°S) during all seasons, and trends close to zero for all seasons over the 30°S–30°N latitude range. For the shortest data period, November 1978 through 1991, there is a clear indication that trends have become more negative in the higher northern latitudes, especially during the winter and spring seasons, and also in the higher southern latitudes in all seasons. A seasonal trend analysis of zonal averages of total ozone mapping spectrometer (TOMS) satellite total ozone data for the comparable period November 1978 through 1991 has also been performed, and moderately good agreement is found between trends in Dobson and TOMS data over this period.
Geochemical characteristics of mafic lavas from the Neotethyan ophiolites in western Turkey: implications for heterogeneous source contribution during variable stages of ocean crust generation

Abstract The Late Triassic to Late Cretaceous age mafic lavas from the Neotethyan suture zone ophiolites in western Turkey exhibit a wide diversity of geochemical signatures, indicating derivation from extremely heterogeneous mantle sources. The rocks as a whole can be divided into three broad subdivisions based on their bulk-rock geochemical characteristics: (1) mid-ocean ridge basalts (MORB) that range in composition from light rare earth element (LREE)-depleted varieties (N-MORB; (La/Sm)N<1) through transitional MORB to LREE enriched types (E-MORB; (La/Sm)N>1); (2) the ocean island basalt (OIB)-type alkaline volcanic rocks with significant enrichment in LILE, HFSE and L-MREE, and a slight depletion in HREE, relative to normal mid-ocean ridge basalts (N-MORB); and (3) the supra-subduction zone (SSZ)-type tholeiites originated from arc mantle sources that are characterized by selective enrichments in fluid-soluble large ion lithophile elements (LILE) and LREE relative to the high field strength elements (HFSE). The formation of MORB tholeiites with variable enrichments and depletions in incompatible trace elements is probably related to the processes of crust generation along an oceanic spreading system, and the observed MORB–OIB associations can be modelled by heterogeneous source contribution and mixing of melts from chemically discrete sources from sub-lithospheric reservoirs. Evaluation of trace element systematics shows that the inferred heterogeneities within the mantle source regions are likely to have originated from continuous processes of formation and destruction of enriched mantle domains by long-term plate recycling, convective mixing and melt extraction. The origin of SSZ-type tholeiites with back-arc basin affinities, on the other hand, can be attributed to the later intra-oceanic subduction and plate convergence which led to the generation of supra-subduction-type oceanic crust as a consequence of imparting a certain extent of subduction component into the mantle melting region. Mixing of melts from a multiply depleted mantle source, which subsequently received variable re-enrichment with a subduction component, is suggested to explain the generation of supra-subduction-type oceanic crust. The geodynamic setting in which much of the SSZ-type ophiolitic extrusive rocks from western Turkey were generated can be described as an arc-basin system that is characterized by an oceanic lithosphere generation most probably associated with melting of mantle material along a supra-subduction-type spreading centre.
Efficient gas exchange between a boreal river and the atmosphere

The largest uncertainties in accurately resolving the role of rivers and streams in carbon cycling stem from difficulties in determining gas exchange between water and the atmosphere. So far, estimates for river‐atmosphere gas exchange have lacked direct ecosystem‐scale flux measurements not disturbing gas exchange across the air‐water interface. We conducted the first direct riverine gas exchange measurements with eddy covariance in tandem with continuous surface water CO2 measurements in a large boreal river for 30 days. Our measured gas transfer velocity was, on average, 20.8 cm h−1, which is clearly higher than the model estimates based on river channel morphology and water velocity, whereas our floating chambers gave comparable values at 17.3 cm h−1. These results demonstrate that present estimates for riverine CO2 emissions are very likely too low. This result is also relevant to any other gases emitted, as their diffusive exchange rates are similarly proportional to gas transfer velocity.
Influence of Soil Spatial Variability and Stochastic Ground-Motion on the Dynamic Behavior of a Slope

A probabilistic dynamic approach is used for the slope stability analysis. In this approach, the effect of both the soil spatial variability and the variability of the Ground-Motion (GM) time history on the dynamic responses (amplification, permanent displacement) are studied and discussed. The soil shear modulus G is considered as an isotropic non-Gaussian random field. The simulation of random acceleration time histories based on a real target accelerogram is done using a fully nonstationary stochastic model in both the time and the frequency domains. The deterministic model is based on numerical simulations. An efficient uncertainty propagation methodology which builds up a sparse polynomial chaos expansion for the dynamic responses is used. The probabilistic numerical results have shown that: (i) the decrease in the autocorrelation distance of the shear modulus leads to a small variability of the dynamic responses; (ii) the randomness of the earthquake GM has a significant influence on the variability of the dynamic responses; (iii) the probabilistic mean values of the dynamic responses are more critical than the deterministic ones.
CALIBRATION OF STORM LOADS IN THE SOUTH PRONG WATERSHED, FLORIDA, USING BASINS/HSPF 1

ABSTRACT: The South Prong watershed is a major tributary system of the Sebastian River and adjacent Indian River Lagoon. Continued urbanization of the Sebastian River drainage basin and other watersheds of the Indian River Lagoon is expected to increase runoff and nonpoint source pollutant loads. The St. Johns River Water Management District developed watershed simulation models to estimate potential impacts on the ecological systems of receiving waters and to assist planners in devising strategies to prevent further degradation of water resources. In the South Prong system, a storm water sampling program was carried out to calibrate the water quality components of the watershed model for total suspended solids (TSS), total phosphorous (TP), and total nitrogen (TN). During the period of May to November 1999, water quality and flow data were collected at three locations within the watershed. Two of the sampling stations were located at the downstream end of major watercourses. The third station was located at the watershed outlet. Five storm events were sampled and measured at each station. Sampling was conducted at appropriate intervals to represent the rising limb, peak, and recession limb of each storm event. The simulations were handled by HSPF (Hydrologic Simulation Program‐Fortran). Results include calibration of the hydrology and calibration of the individual storm loads. The hydrologic calibration was continuous over the period 1994 through 1999. Simulated storm runoff, storm loads, and event mean concentrations were compared with their corresponding observed values. The hydrologic calibration showed good results. The outcome of the individual storm calibrations was mixed. Overall, however, the simulated storm loads agreed reasonably well with measured loads for a majority of the storms.
Divine Wind: The History And Science Of Hurricanes

Imagine standing at the center of a Roman coliseum that is 20 miles across, with walls that soar 10 miles into the sky, towering walls with cascades of ice crystals falling along its brilliantly white surface. That's what it's like to stand in the eye of a hurricane. In Divine Wind, Kerry Emanuel, one of the world's leading authorities on hurricanes, gives us an engaging account of these awe-inspiring meteorological events, revealing how hurricanes and typhoons have literally altered human history, thwarting military incursions and changing the course of explorations. Offering an account of the physics of the tropical atmosphere, the author explains how such benign climates give rise to the most powerful storms in the world and tells what modern science has learned about them. Interwoven with this scientific account are descriptions of some of the most important hurricanes in history and relevant works of art and literature. For instance, he describes the 17th century hurricane that likely inspired Shakespeare's The Tempest and that led to the British colonization of Bermuda. We also read about the Galveston Hurricane of 1900, by far the worst natural calamity in U.S. history, with a death toll between 8,000 and 12,000 that exceeded the San Francisco earthquake, the Johnstown Flood, and the Okeechobee Hurricane combined. Boasting more than one hundred color illustrations, from ultra-modern Doppler imagery to classic paintings by Winslow Homer, Divine Wind captures the profound effects that hurricanes have had on humanity. Its fascinating blend of history, science, and art will appeal to weather junkies, science buffs, and everyone who read Isaac's Storm.
Spontaneous chloroplast mutants mostly occur by replication slippage and 1 show a biased pattern in the plastome of Oenothera

Spontaneous chloroplast mutants mostly occur by replication slippage and 1 show a biased pattern in the plastome of Oenothera 2 3 Authors: Amid Massouh, Julia Schubert, Liliya Yaneva-Roder, Elena S. 4 Ulbricht-Jones, Arkadiusz Zupok, Marc T. J. Johnson, Stephen I. Wright, 5 Tommaso Pellizzer, Johanna Sobanski, Ralph Bock, Stephan Greiner 6 7 Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, D8 14476 Potsdam-Golm, Germany 9 10 Department of Biology, University of Toronto-Mississauga, Mississauga, ON, L5L 11 1C6, Canada 12 13 Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, 14 ON, M5S 3B2, Canada 15 16 Corresponding author: Stephan Greiner 17 greiner@mpimp-golm.mpg. de 18 19 The author responsible for distribution of materials integral to the findings presented 20 in this article in accordance with the policy described in the Instructions for Authors 21 (www.plantcell.org) is: Stephan Greiner (greiner@mpimp-golm.mpg.de). 22 23 Short title: Spontaneous plastome mutants in Oenothera 24 25 Synopsis: Spontaneous chloroplast mutants mostly occur by replication slippage 26 and display a mutation spectrum very different from that in the eukaryotic nucleus 27 and that of bacteria. 28 29 Plant Cell Advance Publication. Published on April 6, 2016, doi:10.1105/tpc.15. 00879
Dynamics of the Agricultural Economy of Andhra Pradesh, India Since the Last Five Decades

Andhra Pradesh is one of the largest state in India, with agriculture as a major source of income for about 60% of its population. In the last 50 years, the annual growth rate of agriculture has been 2.88%, which is far below the target growth of 4% per annum. Further, Andhra Pradesh is divided into three district regions with growing demand for separate state from less developed regions. The paper examined regional disparities in agriculture in Andhra Pradesh since its formation in 1956. The study illustrates that there is a convergence among districts in agricultural growth, but least developed districts are left out of this convergence process. Both agricultural intensification and diversification strategies played important role in development of districts based on their resource endowment. Livestock based agricultural growth is evident in districts adjacent to large urban centres since the last two decades. Overall, TFP growth in agriculture and allied activities in Telangana is 13% per decade, 11% per decade in Coastal, while in Rayalaseema TFP growth has been stagnant from 1956 to 2009. Irrespective of region, the most backward districts in agriculture, that is Srikakulam, Visakhapatnam, Anantapur, Kadapa, Adilabad, Nalgonda, Mahbubnagar and Nizamabad showed stagnation in TFP growth during the last 50 years. With the existing resource endowment and technology, Telangana can increase its output by 28% from the existing level, while Rayalaseema region can enhance its output by 25%, Coastal region by only 14% as revealed from efficiency estimates.
Still no convincing evidence for cognitive map use by honeybees

Cheeseman et al. (1) claim that an ability of honey bees to travel home through a landscape with conflicting information from a celestial compass proves the bees' use of a cognitive map. Their claim involves a curious assumption about the visual information that can be extracted from the terrain: that there is sufficient information for a bee to identify where it is, but insufficient to guide its path without resorting to a cognitive map. We contend that the authors’ claims are unfounded.
Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cells

The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here we characterise AEBP2, a known PRC2 cofactor which, in vitro , has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, including the inactive X chromosome. Proteomic analysis confirms that AEBP2 associates exclusively with PRC2 complexes. However, analysis of embryos homozygous for a targeted mutation of Aebp2 unexpectedly revealed a Trithorax phenotype, normally linked to antagonism of Polycomb function. Consistent with this we observe elevated levels of PRC2 mediated histone H3K27 methylation at target loci in Aebp2 mutant embryonic stem cells. We further demonstrate that mutant ES cells assemble atypical hybrid PRC2 sub-complexes, potentially accounting for enhancement of Polycomb activity, and suggesting that AEBP2 normally plays a role in defining the mutually exclusive composition of PRC2 sub-complexes.
A low‐order dynamical model of global climatic variability over the full Pleistocene

A previously formulated dynamical model of the late Pleistocene ice ages (based on the hypothesis that the global CO{sub 2} system can provide the instability to drive a natural oscillation involving feedbacks between the cryosphere, atmosphere, and ocean) is extended to include (1) additive earth orbital forcing (summer insolation changes at 65{degree}N) and (2) tectonic forcing in the form of a postulated variation in the multiplicative parameters (rate constants) of the model system. The structural (e.g., bifurcation) properties of the model are examined in detail to reveal the regions of parameter space wherein the geologically inferred features of the full Pleistocene can be simulated, including the observed chronology, the phase relationships between ice, CO{sub 2}, and North Atlantic Deep Water formation, and the mid-Pleistocene transition.
The aeolian dust accumulation curve

This article presents a simple physical concept of aeolian dust accumulation, based on the behaviour of the subprocesses of dust deposition and dust erosion. The concept is tested in an aeolian dust wind tunnel. The agreement between the accumulation curve predicted by the model and the accumulation curve obtained in the experiments is close to perfect and shows that it is necessary to discriminate between the processes of aeolian dust deposition and aeolian dust accumulation. Two important thresholds determine the accumulation process. For wind speeds below the deflation threshold, the aeolian accumulation of dust increases linearly with the wind speed. For wind velocities between the deflation threshold and the accumulation limit, the sedimentation balance is above unity and there is still accumulation, though it rapidly drops once the deflation threshold has been exceeded. At wind speeds beyond the accumulation limit, the sedimentation balance is below unity and there will no longer be an accumulation of dust. The thresholds have been determined in a wind tunnel test at friction velocity u* = 0·34 m s−1 (deflation threshold) and u* = 0·43 m s−1 (accumulation limit), but these values are only indicative since they depend heavily on the characteristics of the accumulation surface and of the airborne grains. Copyright © 2001 John Wiley & Sons, Ltd.