Miracle-dz/UniFAR-FTUs huggingface dataset:
Fecal Calprotectin and Phenotype Severity in Patients with Cystic Fibrosis: A Systematic Review and Meta-Analysis

Inflammation plays an important role in the outcome of patients with cystic fibrosis (CF). It may develop due to cystic fibrosis transmembrane conductance regulator protein dysfunction, pancreatic insufficiency, or prolonged pulmonary infection. Fecal calprotectin (FC) has been used as a noninvasive method to detect inflammation. Therefore, the aim of the current meta-analysis was to investigate the relationship between FC and phenotype severity in patients with CF. In this study, searches were conducted in PubMed, Science Direct, Scopus, and Embase databases up to August 2021 using terms such as “cystic fibrosis,” “intestine,” “calprotectin,” and “inflammation. ” Only articles published in English and human studies were selected. The primary outcome was the level of FC in patients with CF. The secondary outcome was the relationship between FC and clinical severity. Statistical analysis was performed using Comprehensive Meta-Analysis software. Of the initial 303 references, only six articles met the inclusion criteria. The mean (95% confidence interval [CI]) level of FC was 256.5 mg/dL (114.1-398.9). FC levels were significantly associated with pancreatic insufficiency (mean, 243.02; 95% CI, 74.3 to 411.6; p=0.005; I2=0), pulmonary function (r=–0.39; 95% CI, –0.58 to –0.15; p=0.002; I2=60%), body mass index (r=–0.514; 95% CI, 0.26 to 0.69; p<0.001; I2=0%), and Pseudomonas colonization (mean, 174.77; 95% CI, 12.5 to 337.02; p=0.035; I2=71%). While FC is a reliable noninvasive marker for detecting gastrointestinal inflammation, it is also correlated with the severity of the disease in patients with CF.
Recognizing speech of people with Parkinson ' s disease

The class of speech disorders known as dysarthria arise from disturbances in muscular control over the speech mechanism caused by damage to the central or peripheral nervous system. Dysarthria is typically classified into one of five classes, each corresponding to a different neurological disorder with distinct prosodic cues (Darley et al., 1969b). The assumption in this classification is that dysarthric speech can be classified based on perception. In this study, we investigated how accurately untrained listeners can recognize stress and intonation in dysarthric speech, and if different neurological disorders impact the ability to convey meaning with these same two cues. To those ends, we collected speech data from Dutch speakers diagnosed with cerebellar lesions (ataxic dysarthria), Parkinson’s disease (hypokinetic dysarthria), Multiple Sclerosis (mixed classes of dysarthria) and from a healthy control group. Thirteen untrained Dutch listeners participated in the perceptual experiment which targeted recognition of intended realization of four prosodic functions: lexical stress, sentence type, boundary marking and focus. We analyzed recognition accuracy for different groups and performed acoustic analyses to check for fundamental frequency trajectories. Results attest to different accuracy recognition results for different speaker groups. The sentence type recognition task was the most sensitive of all tasks for differentiating diseases both by acoustic analysis and by analysis of recognition results. This chapter is adapted from: Verkhodanova V. , Timmermans S. , Coler M. , Jonkers R. , de Jong B. , Lowie W. (2019) How Dysarthric Prosody Impacts Naïve Listeners’ Recognition. In Salah A. , Karpov A. , Potapova R. (eds) Speech and Computer. SPECOM 2019. Lecture Notes in Computer Science, vol 11658. Springer publishing, (pp. 510-519). The paper was slightly adapted for this dissertation.
The Importance of Principal's Managerial Ability and Motivation in Improving Teacher Performance: Case Study in Islamic Based High Schools in West Java, Indonesia

This study discusses the influence of managerial ability and motivation on the performance of Islamic-based secondary school teachers in West Java. This research is Export Facto research. The instrument approves the data using a questionnaire. Samples were taken for 15% of the population of Islamic-based secondary schools in West Java spread across 24 districts/cities in West Java, 53 schools. The number of respondents was 176 teachers. This research was conducted using a survey method with a quantitative approach to test the research hypotheses. The results showed that both partially and simultaneously, the principal's managerial skills and work motivation affected the performance of teachers in Islamic-based schools in West Java.
Still a blind spot for osteoporosis prevention and treatment for rheumatoid arthritis.

In the September issue of The Journal, Drs. Zochling and March commented on our editorial in which we noted the absence of recommendations for the prevention and treatment of osteoporosis in patients with rheumatoid arthritis (RA). They referred to the American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines update 2002, which, they state, addressed the issue of osteoporosis prevention for patients with RA. However, these guidelines contain only the following sentence within the text of the article: “RA is associated with an increased risk of osteoporosis independently of glucocorticoid therapy. ” There is a recommendation for bone mineral densitometry as well as vitamin D and calcium supplement only for RA patients who are taking glucocorticosteroid. But these recently published guidelines, like the 2 we reviewed, as well as the recent consensus statement on pharmacological management of early RA, failed to deal with the need for osteoporosis prevention in RA patients in general. Only the recent article of Haugeberg, et al also raised the question of identifying RA patients at high risk for osteoporosis, identifying 5 criteria: age, weight, inflammation, immobility, and ever-use of corticosteroids. The role of corticosteroids in RA was the principal focus of Drs. Zochling and March, and this was well described in this Guidelines update. However, every patient undergoing glucocorticoid treatment needs bone mineral densitometry evaluation and consideration of treatment for osteoporosis, as recently reiterated by Saag, et al, so this is not specific to patients with RA. This unfortunately reinforces our contention that the prevention and treatment of osteoporosis in patients with RA continues to be insufficiently addressed in published guidelines for management of RA. Our colleagues who work on the osteoporosis side are doing better — as evidenced by the Guidelines on Osteoporosis Management recently published by the Osteoporosis Society of Canada, which list RA as a risk factor for the development of osteoporosis. BRIGITTE M. JOLLES, MD, MSc, Hopital Orthopedique de la Suisse Romande, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 4 Avenue Pierre Decker, 1005 Lausanne, Switzerland. (E-mail: Brigitte.Jolles@chuv.hospvd.ch); EARL R. BOGOCH, MD, MSc, FRCSC, Department of Surgery, University of Toronto, Martin Family Centre for Arthritis Care, Mobility Program, St. Michael’s Hospital, Suite 800, 55 Queen Street East, Toronto, Ontario M5C 1R6, Canada (E-mail: bogoch@sympatico.ca)
Title : Clinical severity and molecular characteristics of circulating and 1 emerging rotaviruses in young children attending hospital emergency 2 departments in France

1 Title: Clinical severity and molecular characteristics of circulating and 1 emerging rotaviruses in young children attending hospital emergency 2 departments in France 3 4 Authors: Alexis de ROUGEMONT* , Jérôme KAPLON , Céline FREMY , Serge AHO , 5 Pierre POTHIER 1,2 and the French National Rotavirus Network. 6 7 The French National Rotavirus Network investigators: Marie-Christine LEGRAND8 GUILLIEN , Adissa MINOUI-TRAN , Christopher PAYAN , Astrid VABRET , Lucile 9 MENDES-MARTINS , Mondher CHOUCHANE , Raphaëlle MAUDINAS , Frédéric 10 HUET , François DUBOS , Didier HOBER , Mouna LAZREK , Christelle 11 BOUQUIGNAUD , Anne DECOSTER , Sophie ALAIN , Jeanne LANGUEPIN , Yves 12 GILLET , Bruno LINA , Yahia MEKKI , Florence MORFIN-SHERPA , Aurélie 13 GUIGON , Jérôme GUINARD , Vincent FOULONGNE , Michel RODIERE , 14 Véronique AVETTAND-FENOEL , Stéphane BONACORSI , Antoine GARBARG15 CHENON , Dominique GENDREL , Pierre LEBON , Mathie LORROT , Patricia 16 MARIANI , Jean-François MERITET , Aurélie SCHNURINGER , Gérard AGIUS , 17 Agnès BEBY-DEFAUX , Denis ORIOT , Ronald COLIMON , Gisèle LAGATHU , 18 Olivier MORY , Sylvie PILLET , Bruno POZZETTO , Jean-Louis STEPHAN . 19 20 * Corresponding author: Dr. Alexis de Rougemont, Centre National de Référence des virus 21 entériques, Laboratoire de Virologie, CHU de Dijon, 2 rue Angélique Ducoudray, BP 37013, 22 F-21070 Dijon Cedex, France; phone number: +33 (0) 380293170; fax number: +33 (0) 23 380293280; email: alexis.de-rougemont@u-bourgogne.fr. 24 25
COMORBIDITIES AND DEATHS BY COVID-19 IN BRAZIL

The new coronavirus outbreak in November 2019 quickly became an international public health emergency. Some studies demonstrate that the poor prognosis of the disease is directly related to the presence of comorbidities, with a risk of death increased by 3.4 times. Thus, the present study aimed to describe the cases of patients with Covid-19 that progressed to death in Brazil, evidencing age, sex, and presence of comorbidities. A retrospective, descriptive study was carried out with secondary data from patients with Covid-19 who progressed to death in Brazil, available on the websites of the health departments of each of the 27 federative units that make up the country. Data were tabulated and frequencies calculated in Microsoft Office Excel® 2007. There were 13,900,091 confirmed cases of Covid-19 until the 59th National Epidemiological Bulletin of 2021, of which 371,678 evolved to death; of them, 61.3% had comorbidities. Among the main comorbidities reported, heart disease (40.1%), diabetes (28.4%), obesity (10.3%), neurological diseases (5.0%), kidney diseases (4.7%) and pneumopathies (4.5%) stand out. In 70% of the cases of patients who died, age equal to or greater than 60 years was observed in males in 55% of the cases. The data obtained corroborate the literature, which indicate a poor prognosis of Covid-19 in patients with one or more comorbidities. Among these, the one that stood out in Brazil during the study period was heart disease.
Supporting Children with Developmental Delays in the General Education Preschool Classroom

Increasing numbers of preschool-age students with developmental delays and other disabilities are educated in the general education classroom. Legislation, including the Individuals with Disabilities Education Act (IDEA), has supported the idea of classroom inclusion. In the inclusive classroom, preschoolers with developmental delays are educated in the least restrictive environment and attend class with typically developing peers. Because high-quality preschool programs already include play-based learning and an individualized curriculum, the preschool classroom naturally yields itself to inclusion practices. Although early childhood professionals may feel unprepared and apprehensive about teaching children with developmental delays, there are many methods available for supporting children with developmental delays that are practical to implement in the preschool classroom. Some ways children with developmental delays are supported in the classroom include specific strategies for inclusion, special education and family support, play-based learning and curriculum, individualized learning techniques, support across developmental domains, environmental strategies, and peer mediation strategies. This paper outlined some of these support methods in more detail by reviewing the literature and presenting specific strategies already practiced and implemented in many high-quality preschool programs.
Development of AR-based Interactive Teaching Materials Equipped with the IBL-STEM Model to Improve the Scientific Literacy of JHS Students on the Topic of the Human Circulatory System

The purpose of this research was to develop interactive teaching materials equipped with the IBL-STEM model to boost students' scientific literacy on the material of the human circulatory system. The research model used is the 4D model which contains 4 steps: (1) Define; (2) Design; (3) Develop; (4) Dissemination. The validation results from lecturer and teacher as material expert validators show a percentage of 94% (very feasible category). This is supported by the high scores obtained from the suitability of inquiry learning and students' skills in determining the relationship between knowledge possessed and daily implementation of the book content which is the goal of IBL-STEM learning. The results of media validation which was also assessed by lecturer and teacher showed a percentage of 96% (very feasible category). The readability test conducted by 30 students showed a percentage of 86% (very good category). Therefore, AR-based interactive teaching materials equipped with the IBL-STEM model can be implemented in classroom learning to improve the scientific literacy of JHS students on the material of the human circulatory system. It is recommended for future research to use this teaching material product in actual learning in the classroom.
Agave durangensis vinasse as a biocide for forest pest control

In forestry practice, the prevention and fight against insect pests and diseases is a priority to preserve the health of these ecosystems. To combat it, insecticides of chemical and biological origin have been used. However, there are alternatives that have not yet been investigated, e.g., the use of agro-industrial waste. In the mezcal distillation process, polluting liquid residues called vinasses are generated, and these can be considered for pest control. In this project, the effect of vinasse from Agave durangensis subjected to different treatments was studied to evaluate its effect on forest phytopathogenic fungi. The mezcal vinasse was characterized physicochemically and by its metabolites. Furthermore, the percentage of inhibition in vitro of phytopathogenic (causing root wilt) fungi isolated from Pinus cooperi seedlings was studied. The fungi inhibition was related to the vinasse concentration. The lower pH and sterile raw vinasse showed a better inhibition effect. Four phytopathogenic strains of Pinus cooperi were isolated and identified, which corresponded to the genera Fusarium, Aspergillus, and Penicillium. None of the isolated were able to grow in potato dextrose-mezcal vinasse medium (PDMVM). Therefore, the mezcal vinasse showed fungicide activity in vitro against all strains.
Development of stomatal conductance of maize under moderately hot, dry production conditions

A field trial was conducted in Hungary, in a moderately warm, dry production area to determine the effect of single or split application of N-fertilizer on the stomatal conductance and grain yield of maize. The measurements were performed at on calcareous chernozem soil, in a strip field trial, under different weather conditions (2019 and 2020). In addition to the unfertilized control (A0) treatment, 60 (A60) and 120 kg N ha (A120) applied as spring basal fertilizer were followed by two top-dressing treatments in V6 (A90) and V12 (A120) phenophases with doses of +30 and +30 kg N ha, respectively. Stomatal conductance measurements were taken at V6, V12 and R1 phenological phases. It was found that stomatal conductance showed a decreasing trend with advancing phenological phases in both years, with 43.9% and 32.1% (P < 0.001; P < 0.01) decreases by the R1 phase, respectively. Application of higher doses of N fertilizer increased stomatal conductance, with the exception of the R1 phenological phase, which showed a decrease compared to the A0 treatment. The decrease in 2019 was caused by a reduction of soil moisture. Although there was sufficient water in the soil in 2020, due to the intermittent water shortages caused by but the large leaf area and rapid transpiration of the plants resulted in the stomata to close. The best fertilisation strategy was A60 and A120 kg ha depending on the crop year. The study showed that the highest yield is obtained when the average stomatal conductance is around 250 mmol m s during the growing season.
INTEREST RATE SENSITIVITY OF MICROCREDIT DEMAND IN BANGLADESH

Microcredit is predominantly perceived to have the purpose of providing access to credit to poor and otherwise marginalized clients. However, for quite some time there is criticism over its ‘high’ interest rate that is expected to impact negatively on borrowers’ demand. This paper examines whether the microcredit demand in Bangladesh is sensitive to interest rate by adopting a simple stochastic demand equation. By using the Household Income and Expenditure Survey (HIES) 2010 data of Bangladesh Bureau of Statistics, the study estimates the demand equation for the households that borrow micro loans from various sources. The initial regression results reveal that interest rate has negative and statistically significant impact of the size of loan while frequency of payment shows the opposite impact in all models. At the second stage, interest rates were disaggregated by broad sources, which show that interest rate of the big microfinance institutions has negative and significant effect on amount of borrowing in all models, while the same of the other sources including bank and government departments demonstrate mixed effects. Finally, disaggregating size of loan for broad sources, the study reveals mixed effects of interest rate.
Online Primal-Dual Algorithms with Predictions for Non-Linear Packing/Covering Problems

The domain of online algorithms with predictions has been extensively studied with new algorithms designed for different problems of scheduling, caching (paging), clustering, ski rental, etc. Recently, Bamas et al., aiming for an unified method, has provided a primal-dual framework for linear covering problems. They extended the online primal-dual method by incorporating predictions in order to achieve a performance beyond the worst-case case analysis. In this paper, we consider this research line and present a framework to design algorithms with predictions for non-linear problems with packing/covering contraints. We illustrate the applicability of our framework through several important problems such as submodular maximization/minimization, energy minimization, load balancing
Auranofin induces urothelial carcinoma cell death via reactive oxygen species production and synergy with cisplatin

Urothelial carcinoma (UC) is one of the most common cancer types of the urinary tract. UC is associated with poor 5-year survival rate, and resistance to cisplatin-based therapy remains a challenge for invasive bladder cancer treatment. Therefore, there is an urgent need to develop new drugs for advanced UC therapy. Auranofin (AF) was developed over 30 years ago for the treatment of rheumatoid arthritis and has been reported to exert an antitumor effect by increasing the level of reactive oxygen species (ROS) in cancer cells. The aim of the present study was to examine the effects of AF on cancer cell proliferation, cell cycle and apoptosis, either alone or in combination with cisplatin. AF induced cell death in two separate cell lines, HT 1376 and BFTC 909, in a concentration- and time-dependent manner by inducing cell cycle arrest. However, the distribution of cells in different phases of the cell cycle differed between the two cell lines, with G0/G1 cell cycle arrest in HT 1376 cells and S phase arrest in BFTC 909 cells. In addition, AF induced apoptosis in HT 1376, as well as redox imbalance in both HT 1376 and BFTC 909 cells. Cell viability was rescued following treatment with N-acetyl-L-cysteine, a ROS scavenger. Furthermore, AF treatment synergistically increased the cytotoxicity of HT 1376 and BFTC 909 cells when combined with cisplatin treatment. These findings suggest that AF may represent a potential candidate drug against UC and increase the therapeutic effect of cisplatin.
DMSP-SSM/I retrieval of proper surface winds during monsoon depression

Recently developed various global microwave algorithms for DMSP-SSM/I satellite data are used for the estimation of surface winds over the Indian ocean. Sea surface wind speeds from these algorithms are compared with sea surface wind speeds reported by coincidental Minicoy island (lowest height 2 m a.s.l.) station over the Arabian sea. A statistical comparison of these algorithms is made in terms of rms error, correlation coefficient, bias and standard deviation. Algorithm of Petty showed best results in the comparison. On the basis of this algorithm a notable characteristic feature such as acquiring of large area of strong surface winds (12-15 ms) to the south of dipping of monsoon trough in head Bay and then encircling of these winds during further development of low and depression (22-27 July 1992) is observed. This complete life cycle monitoring assessment of monsoon depression in respect of surface winds based on DMSP-SSM/I satellite data encourages to utilise our IRS-P4 (Oceansat-1) satellite data at different frequencies to emerge more details of various weather systems over the Indian region.
A REVIEW PAPER ON PARAMETRIC ANALYSIS OF ELECTRIC DISCHARGE MACHINING USING TAGUCHI METHOD

Electric Discharge Machining (EDM) is a thermal electric non conventional machining process in which material removal takes place through the process of controlled spark generation between a pair of electrodes which are submerged in a dielectric medium. In the present paper reviews is conducted of experimental investigations carried out to study the effect of EDM parameters on material removal rate (MRR), Tool Wear Rate (TWR) & surface roughness (Ra). The non-contact machining technique has been continuously growing from a plain tool and dies making process to a micro-scale application machining alternative attracting a significant amount of research interests & offers several special advantages including higher machining rate, better precision and control, and a wider range of materials that can be machined. By use of Taguchi’s method for design of experiment, analysis and optimization. The machining parameters selected as a variables are Pulse off time, Pulse on time, Gap Voltage & Discharge Current. The output measurement includes MRR, TWR and surface roughness.
Power Management for GPU-CPU Heterogeneous Systems

In recent years, GPU-CPU heterogeneous architectures have been increasingly adopted in high performance computing, because of their capabilities of providing high computational throughput. However, current research focuses mainly on the performance aspects of GPU-CPU architectures, while improving the energy efficiency of such systems receives much less attention. There are few existing efforts that try to lower the energy consumption of GPU-CPU architectures, but they address either GPU or CPU in an isolated manner and thus cannot achieve maximized energy savings. In this paper, we propose GreenGPU, a holistic energy management framework for GPU-CPU heterogeneous architectures. Our solution features a twotier design. In the first tier, GreenGPU dynamically splits and distributes workloads to GPU and CPU based on the workload characteristics, such that both sides can finish approximately at the same time. As a result, the energy wasted on staying idle and waiting for the slower side to finish is minimized. In the second tier, GreenGPU dynamically throttles the frequencies of GPU cores and memory in a coordinated manner, based on their utilizations, for maximized energy savings with only marginal performance degradation. Likewise, the frequency and voltage of the CPU are scaled similarly. We implement GreenGPU using the CUDA framework on a real physical testbed with Nvidia GeForce GPUs and AMD Phenom II CPUs. Experiment results with standard Rodinia benchmarks show that GreenGPU achieves 21.04% average energy savings and outperform several well-designed baselines.