Miracle-dz/UniFAR-FTUs huggingface dataset:
The Roles of Human, Nature, and Supernatural Power in Phuoc's The Celestial King Phu Dong and the Iron Horse

Anthropocentrism centralizes the role of humans and human impact on the environment. In folktales, the anthropocentric nuance is amplified by the moral messages delivered after telling the tales. The moral messages are usually for the betterment of humans. This paper intends to offer an alternative reading of a folktale by shifting the focal perspective slightly from human to nature and supernatural beings and their power. The object of this paper is a folktale from Vietnamese culture titled The Celestial King Phu Dong and the Iron Horse. In the tale, the human character could defeat the monster since they had supernatural power. This paper employs three tools to foreground the roles of nature and supernatural power. The folktale's plot is analyzed by its tale elements proposed by Booker (2004). The power relation of the actants is analyzed using Greimas' actantial analysis, and the clause structure is examined by Systemic Functional Linguistic's thematic structure analysis. The result shows that the plot is built upon the opposition between human and nonhuman characters. The actantial analysis indicates that in opposing the nonhuman character, the human character needs help from nature and supernatural power. The thematic patterns structure the delivery of the power relation and the human character dependency. This paper concludes that human character is depicted as dependent on nature and supernatural power in solving problems and obstacles. It foregrounds the agency of objects surrounding humans.
Exploring Paleogeographic Conditions at Two Paleolithic Sites in Navarino, Southwest Greece, Dated by Optically Stimulated Luminescence

In this paper, we employed optically stimulated luminescence (OSL) dating of sediments from two archaeological sites located in Navarino, Messenia, southwestern Greece, to deduce a chronology for the archaeological sites. Archaeological surveys identified two Paleolithic sites on fossilized coastal dunes. Chipped stone tool assemblages were identified eroding out of paleosols developed in the dunes. The assemblage from one site lacked distinct typological features and hence it was difficult to assign to a chronological period. The lithic assemblage from the other site contained artifacts that typologically can be assigned to the Levallois‐Mousterian. Previous efforts to date the artifact‐bearing sediments at these sites were unsuccessful. Using newer OSL dating methods (i.e., the Single‐Aliquot‐Regenerated Dose protocol and thermally transferred‐OSL[TT‐OSL]), we attempted to construct a chronological framework for Late Pleistocene human activity in the southwest Peloponnese. The revised OSL chronology for the first site is 28 ± 5 ka, while a luminescence age of 8 ± 1 ka for the second site only represents a later deflation event. Within the framework of Quaternary environmental change, the location of Paleolithic sites relative to the coast would have changed during the course of the Pleistocene. As a result, Paleolithic exploitation strategies would have been strongly influenced by the changing coastal geomorphology, encouraging hominids to adapt to new distributions of resources. OSL dating of the archaeological sites allowed us to connect traces of hominid activity with climatic stadials/interstadials of the later Pleistocene derived from existing relative sea‐level curves. Ultimately, these data permitted the reconstruction of regional Late Pleistocene paleogeography. © 2012 Wiley Periodicals, Inc.
Opening geometry of the Kurile Basin (Okhotsk Sea) as inferred from structural data

Abstract The Kurile Basin in the Okhotsk Sea, northwestern Pacific, is a back‐arc basin located behind the Kurile Island Arc. It is underlain by oceanic crust and its origin has been attributed to back‐arc spreading. Two models for the opening of the Kurile Basin exist, for which the spreading axis is oriented northeast–southwest and northwest–southeast, respectively. New data are presented here on the morphostructure of the slope of the northern Kurile Basin and of the central Kurile Basin which support a strike of the spreading axis in the latter direction. Bathymetric as well as single‐channel and multichannel seismic reflection data demonstrate the existence of dominant northwest‐striking normal faults on the northern slope of the Kurile Basin. In the central Kurile Basin a basement rise striking north‐northwest–south‐southeast (here named the Sakura Rise) was mapped. The rise morphology has the distinct imprint of a rift structure with symmetrical volcanic edifices on the rise axis and faulted blocks that tilt in opposite directions on the flanks. These data suggest that the Kurile Basin opened in a northeast–southwest direction. In the generally accepted plate tectonic reconstructions, northwest–southeast spreading associated with dextral strike–slip along the north–south‐striking shear zone of Sakhalin and Hokkaido islands has been assumed. In the present model, spreading in the Kurile Basin was presumably connected with dextral displacement along a northeast‐striking shear zone on the southern segment of the Okhotsk Sea.
Antimicrobial Susceptibility and Resistance Genes in Streptococcus uberis Isolated from Bovine Mastitis in the Czech Republic

Streptococcus uberis is one of the most important causative agents of mastitis and is a common reason for the use of antimicrobials in dairy cows. In this study, we assessed the antimicrobial susceptibility of 667 S. uberis isolates originating from 216 Czech dairy farms collected between 2019 and 2023 using the broth microdilution method. We tested 140 of the isolates for the presence of antimicrobial genes using whole-genome sequencing and evaluated their relationship with phenotypic resistance. Streptococcus uberis isolates showed high levels of resistance to tetracycline (59%), followed by streptomycin (38%) and clindamycin (29%). Although all of the isolates were susceptible to beta-lactams, a relatively high percentage of intermediately susceptible isolates was recorded for ampicillin (44%) and penicillin (18%). The isolates were mainly resistant to tetracycline alone (31.3%); the second most frequent occurrence of the phenotypic profile was simultaneous resistance to tetracycline, streptomycin, and clindamycin (16.6%). The occurrence of antibiotic resistance genes did not always match the phenotypic results; in total, 36.8% of isolates that possessed the ant(6)-Ia gene did not show phenotypic resistance to streptomycin. To a lesser extent, silent genes were also detected in clindamycin and tetracycline. This study confirmed the high susceptibility of S. uberis to penicillins used as first-line antimicrobials for S. uberis mastitis treatment.
Temperature‐dependent remineralization in a warming ocean increases surface pCO2 through changes in marine ecosystem composition

Temperature‐dependent remineralization of organic matter is, in general, not included in marine biogeochemistry models currently used for Coupled Model Intercomparison Project Phase 5 (CMIP5) climate projections. Associated feedbacks have therefore not been quantified. In this study we aim at investigating how temperature‐dependent remineralization rates (Q10 = 2) in a warming ocean impact on the marine carbon cycle, and if this may weaken the oceanic sink for anthropogenic CO2. We perturb an Earth system model used for CMIP5 with temperature‐dependent remineralization rates of organic matter using representative concentration pathway (RCP)8.5‐derived temperature anomalies for 2100. The result is a modest change of organic carbon export but also derived effects associated with feedback processes between changed nutrient concentrations and ecosystem structure. As more nutrients are recycled in the euphotic layer, increased primary production causes a depletion of silicate in the surface layer as opal is exported to depth more efficiently than particulate organic carbon. Shifts in the ecosystem occur as diatoms find less favorable conditions. Export production of calcite shells increases causing a decrease in alkalinity and higher surface pCO2. With regard to future climate projections, the results indicate a reduction of oceanic uptake of anthropogenic CO2 of about 0.2 PgC yr−1 toward the end of the 21st century in addition to reductions caused by already identified climate‐carbon cycle feedbacks. Similar shifts in the ecosystem as identified here, but driven by external forcing, have been proposed to drive glacial/interglacial changes in atmospheric pCO2. We propose a similar positive feedback between climate perturbations and the global carbon cycle but driven solely by internal biogeochemical processes.
Comprehensive Systematic Review of Biomarkers in Metastatic Renal Cell Carcinoma: Predictors, Prognostics, and Therapeutic Monitoring

Simple Summary This comprehensive systematic review provides valuable insights into the landscape of biomarkers in clear cell renal cell carcinoma (ccRCC) and their potential applications in the prediction of treatment response, prognosis, and therapeutic monitoring. One of the major challenges in ccRCC is determining the most effective treatment strategies and identifying patients who would benefit from adjuvant or neoadjuvant therapy. This review aims to provide a comprehensive overview of biomarkers in ccRCC and their utility in the prediction of treatment response, prognosis, and therapeutic monitoring in patients receiving systemic therapy for metastatic disease. The findings underscore the importance of incorporating biomarker assessment into clinical practice to guide treatment decisions and improve patient outcomes in ccRCC. Abstract Background: Challenges remain in determining the most effective treatment strategies and identifying patients who would benefit from adjuvant or neoadjuvant therapy in renal cell carcinoma. The objective of this review is to provide a comprehensive overview of biomarkers in metastatic renal cell carcinoma (mRCC) and their utility in prediction of treatment response, prognosis, and therapeutic monitoring in patients receiving systemic therapy for metastatic disease. Methods: A systematic literature search was conducted using the PubMed database for relevant studies published between January 2017 and December 2022. The search focused on biomarkers associated with mRCC and their relationship to immune checkpoint inhibitors, targeted therapy, and VEGF inhibitors in the adjuvant, neoadjuvant, and metastatic settings. Results: The review identified various biomarkers with predictive, prognostic, and therapeutic monitoring potential in mRCC. The review also discussed the challenges associated with anti-angiogenic and immune-checkpoint monotherapy trials and highlighted the need for personalized therapy based on molecular signatures. Conclusion: This comprehensive review provides valuable insights into the landscape of biomarkers in mRCC and their potential applications in prediction of treatment response, prognosis, and therapeutic monitoring. The findings underscore the importance of incorporating biomarker assessment into clinical practice to guide treatment decisions and improve patient outcomes in mRCC.
A Deep Learning-Based IDS for Automotive Theft Detection for In-Vehicle CAN Bus

Driver behavior features extracted from the controller area network (CAN) have potential applications in improving vehicle safety. However, the development of a classifier-based intrusion detection system (IDS) for in-vehicle networks remains an open research problem. To address this challenge, we incorporate novel $n$ -fold cross-validation windowing techniques on two publicly available driving behavior datasets. A driver classification-based IDS is proposed using the LSTM-FCN model that utilizes the strengths of both fully convolutional network (FCN) and long short-term memory (LSTM) networks. These modules allow the model to learn spatial and temporal features and utilize contextual information. In addition, we combine three squeeze and excite (SnE) layers following FCN layers to incorporate adjacent spatial locations and augment a scaled dot product attention mechanism into the LSTM to improve its feature selection and extraction capabilities. Our proposed IDS uses hacking and countermeasure research lab (HCRL) and test datasets, which achieve an improvement in accuracy of 4.18% and 13.99% respectively, from the baseline LSTM-FCN model. The experimental results of our method exhibited an overall accuracy of 99.36% and 96.36% for both datasets and outperformed various state-of-the-art methods.
Analysis of the relationship between inundation frequency and wetland vegetation in Dongting Lake using remote sensing data

Hydrological characteristics significantly drive the formation of and variations in wetland vegetation. Given increasing impact from human activities and climate change, the hydrological regime has become exceedingly unstable, thereby heavily affecting the distribution and dynamics of wetland vegetation. The relationship between inundation frequency – an important hydrological factor – and vegetation community distribution in Dongting Lake was analysed to depict how the hydrological regime determines the distribution of wetland vegetation cover. Wide tempo‐spatial scales were used to calculate the inundation frequency in the lake and to compare the distribution patterns of the communities. For the implementation of the aforementioned tasks, this study provides remote sensing‐ and geographical information system‐based methods. The responses of individual vegetation communities to inundation frequency differ depending on their specific physiological characteristics. Wood and reed communities are more suitable for regions with low inundation frequency, whereas grass and lake‐grass communities are more adaptable to areas of high inundation frequency. The variations in inundation frequency may explain the succession of vegetation communities, which occurs when inundation frequency decreases with increasing wood and reed communities. These results can serve as support for evaluating the impact of hydrological changes on the community structures and distributions of wetland vegetation. Copyright © 2013 John Wiley & Sons, Ltd.
Carbon dioxide injection and resultant alteration of Weber Sandstone (Pennsylvanian-Permian), Rangely field, Colorado

Geologic interpretations made during the current EOR (enhanced oil recovery) project at Rangely field (Rio Blanco County, Colorado), have made interesting connections between alteration of reservoir mineralogy and texture, changes in produced water composition, and increased production problems. Carbon dioxide is being injected into the Weber Sandstone in portions of Rangely field. The carbon dioxide injection is part of a very successful tertiary recovery project initiated in late 1986. The bottomhole pH of Weber brine has decreased from approximately 7.5 to 4.5 with the addition of CO/sub 2/. Changes in the chemistry of produced water are associated with alteration of reservoir mineralogy. The CO/sub 2/ flood has caused a substantial increase in the concentrations of iron, calcium, magnesium, and strontium in the produced brine. The amount of increase is directly related to the volume of CO/sub 2/ produced in each well. This increase resulted from the dissolution of carbonate cements, authigenic clays, and detrital feldspars. An increase in the calculated scaling potential of the produced water is a result of this change in chemistry. Hypotheses based on the water-chemistry changes were confirmed in pressure-cell and core-flood experiments. Core-flood experiments also indicate no net change in permeability following carbon dioxide injection:more » the increase in permeability due to the dissolution of carbonate cements is being offset by a decrease caused by migratory clays plugging pore throats. The clays, which coat the authigenic carbonates, are liberated when the carbonates are dissolved. « less
Anaplastic Lymphoma Kinase Inhibitor-Induced Neutropenia: A Systematic Review

Simple Summary ALK inhibitors have improved survival and quality of life for patients compared to chemotherapy. These treatments can cause haematological toxicities, particularly neutropenia. The management of side effects to avoid treatment interruptions is essential. Our literature review aims to improve the knowledge of ALK inhibitor-induced neutropenia in order to improve their management. Abstract Lung cancers with ALK rearrangement represent less than 5% of all lung cancers. ALK inhibitors are currently used to treat first-line metastatic non-small cell lung cancer with ALK rearrangement. Compared to chemotherapy, ALK inhibitors have improved progression-free survival, overall survival, and quality of life for patients. The results of several phase 3 studies with a follow-up of over 6 years suggest that the life expectancy of these patients treated with targeted therapies is significantly higher than 5 years and could approach 10 years. Nevertheless, these treatments induce haematological toxicities, including neutropenia. Few data are available on neutropenia induced by ALK inhibitors and on the pathophysiological mechanism and therapeutic adaptations necessary to continue the treatment. Given the high efficacy of these treatments, managing side effects to avoid treatment interruptions is essential. Here, we have reviewed the data from published clinical studies and case reports to provide an overview of neutropenia induced by ALK inhibitors.
Exploring Growth, Maturity, and Age as Injury Risk Factors in High-Level Youth Football

Abstract Rapid somatic growth and biological maturity status may affect injury patterns in youth football, yet firm conclusions cannot be drawn from the existing research. We aimed to explore growth velocity, maturity, and age as injury risk factors in 95 academy players (11.9–15.0 years), using anthropometric (height and body mass), maturity (skeletal age), injury, and football exposure data collected prospectively over three seasons (2016/17–2018/19). We compared the relative quality of mixed-effects logistic regression models with growth velocity for 223 growth intervals (average 113 days) included as fixed effects and adjusted for age (chronological or skeletal) plus load (hours/week). Associations were considered practically relevant based on the confidence interval for odds ratios, using thresholds of 0.90 and 1.11 to define small beneficial and harmful effects, respectively. We observed harmful effects of older age on overall (OR: 2.61, 95% CI: 1.15–5.91) and sudden onset (1.98, 1.17–3.37) injury risk. Significant associations (p<0.05) were observed for higher body mass change and greater maturity on sudden onset injuries, and for higher hours/week on gradual onset, bone tissue, and physis injuries. Future studies should include larger samples, monitoring athletes from pre-adolescence through maturation, to enable within-subject analyses and better understand the relationship between growth, maturation, and injuries.
NADPH oxidase contributes to the left ventricular dysfunction induced by sinoaortic denervation in rats

Abstract The aim of this work was to investigate the role nicotinamide adenine dinucleotide phosphate (NADPH) oxidase on left ventricular dysfunction of rats submitted to sinoaortic denervation (SAD). Experiment 1: 8 weeks after SAD of rats, NADPH oxidase in left ventricles was assayed by Western blotting analysis. Experiment 2: Rats were subjected to SAD and received treatment with apocynin (an NADPH oxidase inhibitor, 30 mg/kg/day, intragastric administration) for 8 weeks; 8 weeks after SAD, Nox2 and Nox4 expressions and Rac1 activity of left ventricles were higher in SAD rats than those in sham-operated rats. Although treatment of SAD rats with apocynin did not affect blood pressure, blood pressure variability (BPV), and baroreflex function, it significantly attenuated left ventricular hypertrophy marked by reduced expression of atrial natriuretic factor and β-myosin heavy chain. Treatment of SAD rats with apocynin abated oxidative stress marked by reduced malondialdehyde formation and suppressed nuclear factor-kappa B (NFκB) activation; inflammation marked by reduced monocyte chemoattractant protein-1 expression and myeloperoxidase activity; attenuated endoplasmic reticulum stress marked by reduced expression of CCAAT-enhancer-binding protein homologous protein, chaperone-glucose-regulated protein 78, and X-box protein 1; and alleviated cardiac fibrosis marked by reduced mRNA levels of collagens I and III and transforming growth factor beta. In conclusion, exaggerated BPV induces chronic myocardial oxidative stress and thereby aggravates cardiac remodeling in rats. These data suggest a potential role of NADPH oxidases in the pathogenesis of cardiac dysfunction induced by exaggerated BPV.
People at the tidal flats: coastal morphology andhazards in Iqaluit, Nunavut

Rapid environmental change observed in the Canadian Arctic is driving efforts at federal, territorial, and municipal levels to adapt to the impacts of projected changes. Recent work with communities has shown that targeted and relevant scientific input can greatly enhance ongoing vulnerability assessments and policy planning around adaptation and sustainability. The Arctic coast is dynamic, creating risk to Arctic coastal infrastructure. Using GIS modelling and geoscientific data collected over three field seasons, this thesis reports on a project aimed at providing coastal hazard mapping for Iqaluit, Nunavut. Iqaluit is the capital city of Nunavut, and sits alongside a macrotidal embayment with extensive tidal flats, which influence many aspects of life in the community. Data collected include: detailed topography and bathymetry, elevations of the coastal setting, elevations of past extreme water levels, and morphological mapping. The results build on previous work in Iqaluit, showing a relatively stable boulder-strewn sand flat morphology in the macrotidal embayment. Modelling of the coastal topography indicates a recent (last century) period of quasi stable sea level, with possible slight emergence persisting. Hydrodynamic data reveal little evidence for significant erosion through wave and current input. Recorded nearshore current velocities were between 0.1 - 0.3 m/s, with greater velocities at the top 3 m of the water column. The hazard mapping then attempts to incorporate the morphological mapping into a GIS of coastal infrastructure in the city in order to provide detailed information for city planners. Results show limited freeboard of 0.3-0.8 m for most coastal infrastructure under an upper-limit projection of 0.7 m relative sea-level rise from 2010 to 2100. Key infrastructure, and especially the subsistence infrastructure focused on the coast, is actually below past recorded maximum water levels during high spring tides. Lack of data, however, precludes any reasonable estimate of recurrence. Geomorphological mapping of the coastal setting provides crucial insight into the risks to infrastructure from storm waves, erosion, and sea-level rise. The study shows that the tidal flats are a source of coastal resilience in the form of wave dissipation, lowering ice pile-up/ride-up risk, and protection from rapid erosion.