Miracle-dz/UniFAR-FTUs huggingface dataset:
Material circumstances, health care access, and self-reported health: A latent class analysis

Latent class analysis was used to explore intersections of material circumstances and health care access among 308 adults, and associations between classes with health outcomes. Good fit was found for a four-class model: Resource Stable (Class 1, 62.43%), Unbalanced Meals with Health Care (Class 2, 16.91%), Resource Insecurity with Delayed Health Care (Class 3, 14.75%), and Resource Stability without Access to Health Care (Class 4, 5.91%). Class 1 reported greater well-being and self-rated health than Class 2 and 3. Class 1 reported lower BMI than Class 2. Findings document intersections among economic marginalization indicators with varying health outcomes among classes.
Spatial scale of tuberculosis transmission in Lima, Peru

Significance Understanding the mechanisms of spatial heterogeneity in tuberculosis (TB) transmission may enhance the effectiveness of spatially targeted interventions. In this work, we integrated whole-genome sequences of 2,712 Mycobacterial tuberculosis isolates and geographic coordinates of the patients’ residences in a large urban catchment area in Lima, Peru, to clarify if local transmission is the primary driver of high rates of TB disease in spatially distinct areas. We find that spatially specific TB incidence does not correlate closely to the frequency of local transmission. This suggests that understanding the causes that lead to spatially distinct TB hotspots is necessary for spatially targeting interventions.
Semiclassical formulation of the Gottesman-Knill theorem and universal quantum computation

We give a path integral formulation of the time evolution of qudits of odd dimension. This allows us to consider semiclassical evolution of discrete systems in terms of an expansion of the propagator in powers of $\hbar$. The largest power of $\hbar$ required to describe the evolution is a traditional measure of classicality. We show that the action of the Clifford operators on stabilizer states can be fully described by a single contribution of a path integral truncated at order $\hbar^0$ and so are "classical," just like propagation of Gaussians under harmonic Hamiltonians in the continuous case. Such operations have no dependence on phase or quantum interference. Conversely, we show that supplementing the Clifford group with gates necessary for universal quantum computation results in a propagator consisting of a finite number of semiclassical path integral contributions truncated at order $\hbar^1$ , a number that nevertheless scales exponentially with the number of qudits. The same sum in continuous systems has an infinite number of terms at order $\hbar^1$.
Development of morning–eveningness in adolescence: implications for brain development and psychopathology

Background Morning–evening preference is defined as an individual's preference for a morning‐ or evening‐oriented rhythm. Across adolescence, a preference for eveningness becomes more predominant. Although eveningness is cross‐sectionally associated with internalizing and externalizing psychopathology, few studies have examined developmental changes in eveningness and its potential biological substrates. Here, we investigated the longitudinal relationships among the trajectory of eveningness preference, internalizing and externalizing psychopathology and white matter development, across adolescence. Methods Two‐hundred and nine adolescents (49% male) were assessed longitudinally at four separate time points between 12 and 19 years of age. Morning–evening preference and internalizing and externalizing symptoms were assessed at each time point. Diffusion‐weighted images were acquired on a subset of participants at the final two time points to estimate changes in global mean fractional anisotropy (FA). Linear mixed models were performed to estimate the change in eveningness over time. A series of linear regression models assessed the influence of change in eveningness on psychopathology and white matter development at age 19. Results Across the sample, a preference for eveningness became more predominant by 19 years of age. Greater individual‐level change towards eveningness significantly predicted greater severity in externalizing, but not internalizing, symptoms at 19 years of age. In contrast, change in psychopathology from 12 to 19 years of age was not associated with morning–eveningness at age 19. A change towards eveningness predicted an attenuated increase in FA between 17 and 19 years of age. Conclusions This study suggests that developmental changes in morning–evening preference may predict both neurodevelopmental and psychological outcomes in adolescents.
Lung hamartoma resembling lung cancer: a report of three cases

Pulmonary hamartoma is a benign lung tumor. However, it is difficult to distinguish this lesion from other diseases via imaging. Three patients with pathologically confirmed pulmonary hamartoma in our department were analyzed. We believe it is necessary to combine imaging, pathology, clinical testing, and individual patient assessments to enable an earlier and more definitive diagnosis of pulmonary hamartoma. Therefore, it is necessary to analyze and summarize the clinical manifestations and imaging features of patients with pulmonary hamartoma to improve the early recognition of the disease by clinicians.
LUCIFER@LBT view of star-forming galaxies in the cluster 7C 1756+6520 at z~1.4

Galaxy clusters are key places to study the contribution of {\it nature} (i.e. mass, morphology) and {\it nurture} (i.e.environment) in the formation and evolution of galaxies. Recently, a number of clusters at z$>$1, i.e. corresponding to the first epochs of the cluster formation, has been discovered and confirmed spectroscopically. We present new observations obtained with the {\sc LUCIFER} spectrograph at Large Binocular Telescope (LBT) of a sample of star-forming galaxies associated with a large scale structure around the radio galaxy 7C1756+6520 at z=1.42. Combining our spectroscopic data and the literature photometric data, we derived some of the properties of these galaxies: star formation rate, metallicity and stellar mass. With the aim of analyzing the effect of the cluster environment on galaxy evolution, we have located the galaxies in the plane of the so-called Fundamental Metallically Relation (FMR), which is known not to evolve with redshift up to z$=2.5$ for field galaxies, but it is still unexplored in rich environments at low and high redshift. We found that the properties of the galaxies in the cluster 7C 1756+6520 are compatible with the FMR which suggests that the effect of the environment on galaxy metallicity at this early epoch of cluster formation is marginal. As a side study, we also report the spectroscopic analysis of a bright AGN, belonging to the cluster, which shows a significant outflow of gas.
Real‐time assessment of positive and negative affective fluctuations and mood lability in a transdiagnostic sample of youth

Emotional lability, defined as rapid and/or intense affect fluctuations, is associated with pediatric psychopathology. Although numerous studies have examined labile mood in clinical groups, few studies have used real‐time assessments in a well‐characterized transdiagnostic sample, and no prior study has included participants with disruptive mood dysregulation disorder (DMDD). The present study leverages ecological momentary assessment (EMA) to assess emotional lability in a transdiagnostic pediatric sample.
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the World Health Organization (WHO). Early clinical symptomatology focused mainly on respiratory illnesses. However, a variety of neurological manifestations in both adults and newborns are now well-documented. To experimentally determine whether SARS-CoV-2 could replicate in and affect human brain cells, we infected iPSC-derived human brain organoids. Here, we show that SARS-CoV-2 can productively replicate and promote death of neural cells, including cortical neurons. This phenotype was accompanied by loss of excitatory synapses in neurons. Notably, we found that the U.S. Food and Drug Administration (FDA)-approved antiviral Sofosbuvir was able to inhibit SARS-CoV-2 replication and rescued these neuronal alterations in infected brain organoids. Given the urgent need for readily available antivirals, these results provide a cellular basis supporting repurposed antivirals as a strategic treatment to alleviate neurocytological defects that may underlie COVID-19- related neurological symptoms.
Dynamic cerebral autoregulation is intact in chronic kidney disease

Chronic Kidney Disease (CKD) patients experience an elevated risk for cerebrovascular disease. One factor that may contribute to this heightened risk is an impairment in dynamic cerebral autoregulation, the mechanism by which cerebral vessels modulate cerebral blood flow during fluctuations in arterial pressure. We hypothesized that dynamic cerebral autoregulation would be impaired in CKD. To test this hypothesis, we compared dynamic cerebral autoregulation between CKD patients stages III‐IV and matched controls (CON) without CKD. Fifteen patients with CKD and 20 CON participants performed 2, 5‐minute bouts of repeated sit‐to‐stand maneuvers at 0.05 Hz and 0.10 Hz while mean arterial pressure (MAP, via finger photoplethysmography) and middle cerebral artery blood velocity (MCAv, via transcranial Doppler ultrasound) were measured continuously. Cerebral autoregulation was characterized by performing a transfer function analysis (TFA) on the MAP‐MCAv relationship to derive coherence, phase, gain, and normalized gain (nGain). We observed no group differences in any of the TFA metrics during the repeated sit‐to‐stand maneuvers. During the 0.05 Hz maneuver, Coherence: CKD = 0.83 ± 0.13, CON = 0.85 ± 0.12, Phase (radians): CKD = 1.39 ± 0.41, CON = 1.25 ± 0.30, Gain (cm/s/mmHg): CKD = 0.69 ± 0.20, CON = 0.71 ± 0.22, nGain (%/mmHg): CKD = 1.26 ± 0.35, CON = 1.20 ± 0.28, p ≥ 0.24. During the 0.10 Hz maneuver (N = 6 CKD and N = 12 CON), Coherence: CKD = 0.61 ± 0.10, CON = 0.67 ± 0.11, Phase (radians): CKD = 1.43 ± 0.26, CON = 1.30 ± 0.23, Gain (cm/s/mmHg): CKD = 0.75 ± 0.15, CON = 0.84 ± 0.26, nGain (%/mmHg): CKD = 1.50 ± 0.28, CON = 1.29 ± 0.24, p ≥ 0.12. Contrary to our hypothesis, dynamic cerebral autoregulation remains intact in CKD stages III‐IV. These findings suggest that other mechanisms likely contribute to the increased cerebrovascular disease burden experienced by this population. Future work should determine if other cerebrovascular regulatory mechanisms are impaired and related to cerebrovascular disease risk in CKD.
Dim light melatonin onset following simulated eastward travel is earlier in young males genotyped as PER35/5 than PER34/4

ABSTRACT Inter-individual variability exists in recovery from jetlag following travel across time zones. Part of this variation may be due to genetic differences at the variable number tandem repeat (VNTR) polymorphism of the PERIOD3 (PER3) gene as this polymorphism has been associated with chronotype and sleep, as well as sensitivity to blue light on melatonin suppression. To test this hypothesis we conducted a laboratory-based study to compare re-entrainment in males genotyped as PER34/4 (n = 8) and PER35/5 (n = 8) following simulated eastward travel across six time zones. The recovery strategy included morning blue-enriched light exposure and appropriately-timed meals during the first 24 h after simulated travel. Dim light melatonin onset (DLMO), sleep characteristics, perceived sleepiness levels (Stanford Sleepiness Scale), and resting metabolic parameters were measured during constant routine periods before and after simulated travel. While DLMO time was similar between the two groups prior to simulated eastward travel (p = .223), it was earlier in the PER35/5 group (17h23 (17h15; 17h37)) than the PER34/4 group (18h05 (17h53; 18h12)) afterwards (p = .046). During resynchronisation, perceived sleepiness and metabolic parameters were similar to pre-travel in both groups but sleep was more disturbed in the PER35/5 group (total sleep time: p = .008, sleep efficiency: p = .008, wake after sleep onset: p = .023). The PER3 VNTR genotype may influence the efficacy of re-entrainment following trans-meridian travel when blue-enriched light exposure is incorporated into the recovery strategy on the first day following travel.
Impacts of Social Isolation on the Physical and Mental Health of Older Adults During Quarantine: A Systematic Review

ABSTRACT Objectives To systematically review articles that reported the impacts of social isolation on the physical and mental health of healthy older adults during the coronavirus disease 2019 (Covid-19) quarantine. Methods Electronic search was performed in PubMed, EMBASE, Web of Science, Scopus, and BIREME databases. It included cohort and cross-sectional studies published between January 2020 and January 2022 which evaluated the impacts of social isolation on the physical and mental health of older adults during quarantine. The study was registered in PROSPERO (CRD42021269720). Results Out of 8,505 studies identified, 17 met the inclusion criteria, with moderate to excellent quality. The majority of the older population perceived changes in their physical and mental health. Impacts differed in cohorts according to sex, age group, income, social participation, exercising before and during confinement, and living alone or with other people. Conclusions The long period of social isolation dictated by the COVID-19 pandemic caused changes in most older adults`, reducing levels of physical activity and/or generating depression, anxiety, fear, and mood problems. Follow-up studies are necessary to observe the evolution of these impacts. Clinical implications Public policies must be developed to promote the emotional and physical health of the older adult population in the post-pandemic period.
Colloquium: Random matrices and chaos in nuclear spectra

Chaos occurs in quantum systems if the statistical properties of the eigenvalue spectrum coincide with predictions of random-matrix theory. Chaos is a typical feature of atomic nuclei and other self-bound Fermi systems. How can the existence of chaos be reconciled with the known dynamical features of spherical nuclei? Such nuclei are described by the shell model (a mean-field theory) plus a residual interaction. The question is answered using a statistical approach (the two-body random ensemble): The matrix elements of the residual interaction are taken to be random variables. Chaos is shown to be a generic feature of the ensemble and some of its properties are displayed, emphasizing those which differ from standard random-matrix theory. In particular, the existence of correlations among spectra carrying different quantum numbers is demonstrated. These are subject to experimental verification.
Discovery of Tidal RR Lyrae Stars in the Bulge Globular Cluster M62

The RR Lyrae (RRL) rich globular cluster M62 (NGC 6266) is one of the most massive globular clusters in the Milky Way, located in the dense region of the Galactic bulge, where dynamical processes that affect the survival of globular clusters are maximized. Using Gaia second data release data we have found clear evidence for an excess of RRLs beyond the cluster tidal radius of M62, associated partly with stars stripped into the Galaxy field. This is confirmed with new Visible and Infrared Survey Telescope for Astronomy Variables in the Via Lactea Extended survey observations, which discard any differential reddening effect as the possible cause of the observed RRL density excess. We also determined the orbit of M62 using accurate new measurements of its distance, radial velocity, and proper motions, finding that its orbit is prograde with respect to the direction of the Galactic rotation. Orbits are integrated in the non-axisymmetric galactic model GravPot16, which includes the perturbations due to the central Galactic bar. M62 shows a particular orbital behavior, having a dynamical signature of the bar-bulge region. The small extra-tidal RRLs extensions that are observed are roughly aligned toward the galactic center, and the direction is almost perpendicular to the galactic plane, not with its motion along its orbit. This may be a clear sign of bulge-crossing shocks during the last passage close of the cluster toward its perigalacticon. M62 would be the first clear observed case of bulge shocking in the inner Galaxy acting on a globular cluster.
M3NAS: Multi-Scale and Multi-Level Memory-Efficient Neural Architecture Search for Low-Dose CT Denoising

Lowering the radiation dose in computed tomography (CT) can greatly reduce the potential risk to public health. However, the reconstructed images from dose-reduced CT or low-dose CT (LDCT) suffer from severe noise which compromises the subsequent diagnosis and analysis. Recently, convolutional neural networks have achieved promising results in removing noise from LDCT images. The network architectures that are used are either handcrafted or built on top of conventional networks such as ResNet and U-Net. Recent advances in neural network architecture search (NAS) have shown that the network architecture has a dramatic effect on the model performance. This indicates that current network architectures for LDCT may be suboptimal. Therefore, in this paper, we make the first attempt to apply NAS to LDCT and propose a multi-scale and multi-level memory-efficient NAS for LDCT denoising, termed M3NAS. On the one hand, the proposed M3NAS fuses features extracted by different scale cells to capture multi-scale image structural details. On the other hand, the proposed M3NAS can search a hybrid cell- and network-level structure for better performance. In addition, M3NAS can effectively reduce the number of model parameters and increase the speed of inference. Extensive experimental results on two different datasets demonstrate that the proposed M3NAS can achieve better performance and fewer parameters than several state-of-the-art methods. In addition, we also validate the effectiveness of the multi-scale and multi-level architecture for LDCT denoising, and present further analysis for different configurations of super-net.
COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection

Genome wide association studies show there is a genetic component to severe COVID-19. We find evidence that the genome-wide genetic association signal with severe COVID-19 is correlated with that of systemic lupus erythematosus (SLE), having formally tested this using genetic correlation analysis by LD score regression. To identify the shared associated loci and gain insight into the shared genetic effects, using summary level data we performed meta-analyses, a local genetic correlation analysis and fine-mapping using stepwise regression and functional annotation. This identified multiple loci shared between the two traits, some of which exert opposing effects. The locus with most evidence of shared association is TYK2, a gene critical to the type I interferon pathway, where the local genetic correlation is negative. Another shared locus is CLEC1A, where the direction of effects is aligned, that encodes a lectin involved in cell signaling, and the anti-fungal immune response. Our analyses suggest that several loci with reciprocal effects between the two traits have a role in the defense response pathway, adding to the evidence that SLE risk alleles are protective against infection.
Adult mixed phenotype acute leukemia (MPAL): B/myeloid MPALisoMPO is distinct from other MPAL subtypes

Myeloperoxidase (MPO) is considered a specific marker of myeloid/non‐monocytic lineage in the diagnosis of mixed phenotype acute leukemia (MPAL). However, the clinical significance of isolated dim MPO expression in otherwise typical B lymphoblastic leukemia (B‐ALL; referred to as B/myeloid MPALisoMPO) in adult patients is unknown.
Distinct phenotypic clusters of sleep‐disordered breathing and their association with medical care‐seeking behaviour and sleep habits: the Guangdong Sleep Health Study

Sleep‐disordered breathing (SDB) is highly prevalent, but its rates of diagnosis and treatment are low. As a heterogeneous condition, it is associated with delayed diagnosis and/or suboptimal treatment. We aimed to determine distinct SDB clusters and examine their association with medical care‐seeking behaviour and sleep habits in a community‐dwelling population in South China. Participants were enrolled in the ‘Guangdong Sleep Health Study’. Five distinct community sites were investigated. Participant information was collected, and overnight sleep monitoring was performed. Latent class analysis was performed to classify patients with SDB based on patterns of SDB‐related symptoms and signs. Overall, 1,524 patients with SDB were evaluated. Four distinct clusters were identified: ‘minimally symptomatic’ (Cluster 2), which was the most dominant subtype (41.6%), followed by ‘pure insomnia/fewer daytime symptoms’ (Cluster 4; 24.7%), ‘insomnia/multiple daytime symptoms’ (Cluster 3; 17.8%), and ‘upper airway symptoms with sleepiness’ (Cluster 1; 15.9%). The overall medical care‐seeking rate attributable to sleep and breathing disorders was only 3.3%: 10.3% in Cluster 3, 2.5% in Cluster 1, 2.1% in Cluster 4, and 1.3% in Cluster 2, in which Cluster 3 was the highest and Cluster 2 was the lowest (adjusted p < 0.05). Regarding the sleep habit of going to bed and waking up at a consistent time, Cluster 3 exhibited the worst performance and Cluster 2 the best. In conclusion, distinct phenotypic subtypes were identified in community‐dwelling patients with SDB. Tailored strategies to encourage medical care‐seeking, early identification, and optimisation of treatment are necessary considering the different subtypes.
Problematic internet use and attachment styles among adolescents in Japan

Problematic Internet use (PIU) remains a significant social concern in Japan and across the globe. Numerous studies have been conducted to examine the prevalence of PIU, and its association with lifestyle habits and mental health status. To the best of our knowledge, few studies have examined the association between parental attachment and PIU in Japan. Furthermore, preventive measures in Japan have primarily targeted adolescents via education. Therefore, in this study we explored the association between PIU and attachment styles among adolescents to seek a new approach for the development of appropriate, effective measures.
Discovery of an Active Intermediate-mass Black Hole Candidate in the Barred Bulgeless Galaxy NGC 3319

We report the discovery of an active intermediate-mass black hole (IMBH) candidate in the center of nearby barred bulgeless galaxy NGC 3319. The point X-ray source revealed by archival Chandra and XMM-Newton observations is spatially coincident with the optical and UV galactic nuclei from Hubble Space Telescope observations. The spectral energy distribution derived from the unresolved X-ray and UV-optical flux is comparable with active galactic nuclei rather than ultraluminous X-ray sources, although its bolometric luminosity is only . Assuming an Eddington ratio range between 0.001 and 1, the black hole mass ( ) will be in the range 3 × 102 −3 × 105 , placing it in the so-called IMBH regime and making it possibly one of the lowest reported so far. Estimates from other approaches (e.g., fundamental plane, X-ray variability) also suggest ≲ 105 . Similar to other BHs in bulgeless galaxies, the discovered IMBH resides in a nuclear star cluster with mass of ∼6 × 106 . The detection of such a low-mass BH offers us an ideal chance to study the formation and early growth of SMBH seeds, which may result from the bar-driven inflow in late-type galaxies with a prominent bar such as NGC 3319.