Miracle-dz/UniFAR-FTUs huggingface dataset:
Economic impact of political ties in Vietnam: Evidence from northern rural households

This paper focuses on investigating the impacts of political connections on households’ income and their agricultural investment in mountainous areas of Vietnam by employing several matching methodologies. Propensity score matching (PSM) is an increasingly wellknown approach for evaluation studies in agricultural economics. Additionally, this study attempts to verify the significance of political connection in rural economics. To conduct the empirical approach, the article uses surveyed data of 550 households from three provinces in the north of Vietnam. The findings indicate that political connection has a significantly positive impact on households’ total income and farming behaviour, but has a very negative impact on households’ agricultural investment. The difference between the income of the connected and non-connected group of households is estimated at approximately 30 million VND (US$ 1,304) per year. However, the total income of the connected households is not heavily based on agricultural production, their non-agricultural activities account for a larger share of their total income. Another important outcome is to confirm the privileges of politically connected households in terms of receiving extension courses that substantially increase the inequality between rural households in survey areas because the distribution of government subsidy is distorted to target the necessities.
The of Attributes and

Generally, a majority of consumers support the idea of purchasing green products,. However, this is often not translated in actual behaviour. We argue that there is a trade-off between the influence of product attributes on purchasing decisions, whereby it is assumed that consumers tend to focus on egoistic product characteristics first, followed by green product characteristics. In two experimental studies ( N =100 and N =107) we find support for this reasoning: if product attributes fulfil self-serving motives (low price, familiar or well-known brand) green product attributes (cruelty free and low environmental impact) influence purchasing intentions more than when self-serving motives are not fulfilled (high price, unfamiliar or unknown brand). Further, we investigated if and how values weaken or strengthen the influence of product attributes on purchasing intentions. We conclude that biospheric values steer how product attributes influence purchasing intentions stronger than egoistic values. In line with our expectations, we find that if biospheric values are weak, egoistic product attributes are more influential, whereas if biopheric values are strong green product attributes are more influential.
Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt Kinase/AMP-Dependent Protein Kinase/Target of Rapamycin Complex 2 Pathway in Diet-Induced Insulin Resistance

Nesfatin-1, derived from nucleobindin 2, was recently identified as an anorexigenic signal peptide. However, its neural role in glucose homeostasis and insulin sensitivity is unknown. To evaluate the metabolic impact and underlying mechanisms of central nesfatin-1 signaling, we infused nesfatin-1 in the third cerebral ventricle of high-fat diet (HFD)–fed rats. The effects of central nesfatin-1 on glucose metabolism and changes in transcription factors and signaling pathways were assessed during euglycemichyperinsulinemic clamping. The infusion of nesfatin-1 into the third cerebral ventricle markedly inhibited hepatic glucose production (HGP), promoted muscle glucose uptake, and was accompanied by decreases in hepatic mRNA and protein expression and enzymatic activity of PEPCK in both standard dietand HFD-fed rats. In addition, central nesfatin-1 increased insulin receptor (InsR)/insulin receptor substrate-1 (IRS-1)/AMPdependent protein kinase (AMPK)/Akt kinase (Akt)/target of rapamycin complex (TORC) 2 phosphorylation and resulted in an increase in Fos immunoreactivity in the hypothalamic nuclei that mediate glucose homeostasis. Taken together, these results reveal what we believe to be a novel site of action of nesfatin-1 on HGP and the PEPCK/InsR/IRS-1/AMPK/Akt/TORC2 pathway and suggest that hypothalamic nesfatin-1 action through a neuralmediated pathway can contribute to increased peripheral and hepatic insulin sensitivity by decreasing gluconeogenesis and promoting peripheral glucose uptake in vivo.
Study of relaxation and dielectric response of polyimide films

In recent years, polyimides are more and more used as high performance polymers because of their excellent thermal, mechanical and electrical properties. In this work, dielectric properties and relaxation behavior of some Polyimide films were studied on the basis of dielectric constant, dielectric loss and AC conductivity taking into account their variation with frequency and temperature. According to the results, three types of relaxations α, β and γ at decreasing temperature were detected, the origin of these relaxations and the influence of the chemical structure on changes in dielectric and electrical properties were discussed. RÉSUMÉ. Au cours des dernières années, les polyimides sont de plus en plus utilisés comme des polymères à hautes performances en raison de leurs excellentes propriétés thermiques, mécaniques et électriques. Dans ce travail, les propriétés et la relaxation diélectriques de certains films polyimides ont été étudiés sur la base de la constante diélectrique, le facteur de perte diélectrique et la conductivité AC en tenant compte de leur variation avec la fréquence et de la température. D'après les résultats obtenus, trois types de relaxations α, β et γ à température décroissante ont été détectés, l’origine de ces relaxations et l’influence de la structure chimique sur les variations des propriétés diélectriques et électriques ont été discutées.
Job Insecurity and Work Meaning among Romanian Sports Coaches

The present study analyzed the relationships among material difficulties, job insecurity, work meaning and the mental health of sports coaches. Participants for this study were 200 coaches (120 men and 80 women, aged between 18 and 60 years, M = 41.04, SD = 8.71). The instruments used were (a) The Difficulties List, (b) Qualitative Job Insecurity, (c) Quantitative Job Insecurity, (d) The Work and Meaning Inventory, Depression, Anxiety, and Stress Scales. Statistical analysis was performed through SPSS 24. The results obtained by three multiple mediations showed that material difficulties were not directly associated with depression, anxiety, and stress. Although qualitative job insecurity mediates the relationship between material difficulties and mental health (β = 0.14, p < 0.01 for depression, β = 0.17, p < 0.01 for anxiety, and β = 0.14, p < 0.01 for stress) quantitative job insecurity and work meaning do not mediate this relationship but had significant direct effects. The conclusions of the study led to the need for material and psychological support for coaches to have a meaningful activity, so that they could achieve significant performance with their athletes.
Cloning and Bacterial Expression of the CYS 3 Gene Encoding Cystathionine y-Lyase of Saccharomyces cerevisiae and the Physicochemical and Enzymatic Properties of the Protein SHUZO YAMAGATA , 1 *

By screening a yeast genomic library, we isolated and characterized a gene rescuing the cysteine requirement in a "cysi" strain of Saccharomyces cereviswe. Except for four residues in the open reading frame composed of 1,182 nucleotides, the DNA sequence was the same as that for the CYS3 (CYil) gene, encoding cystathionine -y-lyase (EC 4.4.1.1), and isolated previously as a cycloheximide-induced gene (B. Ono, K. Tanaka, K. Naito, C. Heike, S. Shinoda, S. Yamamoto, S. Ohmori, T. Oshima, and A. Toh-e, J. Bacteriol. 174:pp.3339-3347, 1992). S. cerevisiae "cysi" strains carry two closely linked mutations; one (cysl) causes a defect in serine O-acetyltransferase (EC 2.3.1.30), and another, designated cys3, impairs cystathionine y-lyase activity. Rescue of the cysteine requirement by the gene encoding cystathionine -y-lyase is consistent with both defects being responsible for the cysteine auxotrophy. In an effort to further determine the physicochemical and enzymatic properties of this enzyme, a coding fragment was cloned into an Escherichia coli expression plasmid, and the protein was produced in the bacteria. The induced protein was extracted by sonication and purified to homogeneity through one course of DEAE-cellulose column chromatography. The yield of the protein was approximately 150 mg from cells cultured in 1 liter of L broth. The protein showed molecular weights of approximately 194,000 and 48,000 (for the subunit), suggesting a tetrameric structure. An S2, W value of 8.8 was estimated by centrifugation in a sucrose concentration gradient. No sulfhydryl groups were detected, which is consistent with the absence of cysteine residues in the coding sequence. The isoelectric point was at pH 5.2. The protein showed a number of cystathionine-related activities, i.e., cystathionine 13-lyase (EC 4.4.1.8), cystathionine y-flyase, and cystathionine -y-synthase (EC 4.2.99.9) with L-homoserine as a substrate. In addition, we demonstrated L-homoserine sulfhydrylase (adding H2S) activi but could find no detectable seine O-acetyltransferase activity. In this paper, we compare the enzymatic properties of the protein with those of homologous enzymes previously reported and discuss the possibility that this enzyme has a physiological role as cystathionine 1-lyase and cystathionine -y-synthase in addition to its previously described role as cystathionine -y-lyase.
A Novel Study for Spatio-Temporal Query Processing using Privacy Preservation

-The prevailing infrastructure of ubiquitous computing paradigm on the one hand making significant development for integrating technology in the daily life but on the other hand raising concerns for privacy and confidentiality. As Location based services (LBS) equip users to query information specific to a location with respect to temporal and spatial factors thus LBS put under extreme criticism when it comes to location privacy and user confidentiality. Here in this paper we are addressing the significance of our proposed scheme, a query processing architecture for privacy preservation in LBS, by providing flexible and efficient LBS model to ensure accurate and qualitative result set by employing some indexing scheme at location anonymizer as well as by Identifying possible adversary attacks to breach user privacy in the previous work with respect to location privacy and query privacy. Realizing the need for a unanimous query processing model which can operate in centralize as well as distributed environment, also flexible enough to provide privacy for public queries (snapshot/continuous) as well as private queries (snapshot/continuous) for public and private locations. Finally we will quantify the benefits of our approach using sampled results through experiments that the proposed cloaking algorithm is scalable, efficient and robust to support anonymity irrespective of scale of user queries in real time scenario.
CMAR_A_240108 4117..4128

Yongkang Chen Yong Yang 1 Jin Gu 1–3 1Department of Gastrointestinal Surgery III, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, People’s Republic of China; 2Department of Gastrointestinal Surgery, Peking University Shougang Hospital, Beijing 100144, People’s Republic of China; 3Peking-Tsinghua Center for Life Science, Tsinghua University, Beijing 100142, People’s Republic of China Abstract: Intestinal microbiome influences host immunity and several diseases, including cancer, in their areas of colonization. Microbial dysbiosis and over-colonization of specific microbes within the colorectal mucosa can impact the progress of carcinogenesis. Investigations initially focused on the mechanisms by which the intestinal microbiome initiates or promotes the development of colorectal cancer, including DNA damage, induction of chromosomal instability, and regulation of host immune responses. Some studies on the clinicopathological features have reported that specific strains present at high abundance are associated with advanced stage and positive lymph nodes in colorectal cancer. In this context, we reviewed the relationship between the intestinal microbiome and the clinical features (patient age, disease staging, prognosis, etc.) of patients with colorectal cancer, and evaluated the potential pathogenesis caused by the intestinal microbiome in disease progress. This article assessed whether changes in distinct species or strains occur during the period of cancer advancement. Overall, age grouping does not bring about significant differences in the constitution of microbiome. The disease stages show their distinct distribution in some species and strains. Oncogenic species are generally enriched in patients with poor prognosis, including low infiltration of CD3 T cells, poor differentiation, widespread invasion, high microsatellite instability, CpG island methylator phenotype, BRAF mutation, short overall survival, and disease-free survival. The implications of those changes we discussed may assist in comprehensive understanding of the tumorigenesis of colorectal cancer from a microbiological perspective, finding potential biomarkers for colorectal cancer.
Revealing buckling of an apparently flat monolayer of NaCl on Pt(111)

Platinum is relatively reactive, compared to silver and copper, which prompted us to study the growth and structure of a thin insulating layer on Pt(111). We grew monolayer islands of NaCl and studied them with scanning tunneling microscopy (STM) and atomic force microscopy (AFM). STM images of the islands revealed a square lattice which we confirmed, via density functional theory (DFT) calculations, to be the Cl anions, similar to other surfaces. Surprisingly, however, the AFM images appeared to only resolve approximately two-thirds of the Cl ions. DFT calculations showed that the adsorption heights of the Cl anions above the surface have a bimodal distribution in which they are either approximately 60 pm above the Na ionic plane or 40 pm lower. An electrostatic model shows that this structure reproduces the AFM observations.
The small FNR regulon of Neisseria gonorrhoeae: comparison with the larger Ecoli FNR regulon and interaction with the NarQ-NarP regulon

Background: Neisseria gonorrhoeae can survive during oxygen starvation by reducing nitrite to nitrous oxide catalysed by the nitrite and nitric oxide reductases, AniA and NorB. The oxygen-sensing transcription factor, FNR, is essential for transcription activation at the aniA promoter, and full activation also requires the two-component regulatory system, NarQ-NarP, and the presence of nitrite. The only other gene known to be activated by the gonococcal FNR is ccp encoding a cytochrome c peroxidase, and no FNR-repressed genes have been reported in the gonococcus. In contrast, FNR acts as both an activator and repressor involved in the control of more than 100 operons in E. coli regulating major changes in the adaptation from aerobic to anaerobic conditions. In this study we have performed a microarray-led investigation of the FNR-mediated responses in N. gonorrhoeae to determine the physiological similarities and differences in the role of FNR in cellular regulation in this species. Results: Microarray experiments show that N. gonorrhoeae FNR controls a much smaller regulon than its E. coli counterpart; it activates transcription of aniA and thirteen other genes, and represses transcription of six genes that include dnrN and norB . Having previously shown that a single amino acid substitution is sufficient to enable the gonococcal FNR to complement an E. coli fnr mutation, we investigated whether the gonococcal NarQ-NarP can substitute for E. coli NarX-NarL or NarQ-NarP. A plasmid expressing gonococcal narQ-narP was unable to complement E. coli narQP or narXL mutants, and was insensitive to nitrate or nitrite. Mutations that progressively changed the periplasmic nitrate sensing region, the P box, of E. coli NarQ to the sequence of the corresponding region of gonococcal NarQ resulted in loss of transcription activation in response to the availability of either nitrate or nitrite. However, the previously reported ligand-insensitive ability of gonococcal NarQ, the "locked on" phenotype, to activate either E. coli NarL or NarP was confirmed. Conclusion: Despite the sequence similarities between transcription activators of E. coli and N. gonorrhoeae , these results emphasise the fundamental differences in transcription regulation between these two types of pathogenic bacteria. to search the gonococcal DNA sequences.
Medium-term clinical outcomes of Zone 2B/2C finger flexor tendon repairs: influence of management of flexor digitorum superficialis

The aim of our study was to compare the medium-term clinical and functional outcomes of early repair of a complete Zone 2B or 2C transection of the flexor digitorum profundus tendon associated with either the repair of the two slips of the flexor digitorum superficialis tendon, only one slip repaired (the other slip was resected) or no slips repaired (both slips were resected). The outcomes of these three repair techniques were compared based on the total active motion, residual flexion deformity of the proximal interphalangeal joint, Strickland’s formula and Tang classification, Disability of Arm Shoulder and Hand score and complications. The study reviewed 61 fingers (51 patients) at a mean follow-up of 89.5 months. There was no significant difference in finger mobility comparing the three techniques for management of flexor digitorum superficialis. All but one patient returned to work and the DASH score (mean 6.9) suggests that function does not appear to be greatly affected. Level of evidence III
Using Community Health Workers to Improve Health Outcomes in a Sample of Hispanic Women and Their Infants: Findings from a Randomized Controlled Trial

Introduction: The Maternal Infant Health Outreach Worker (MIHOW) program, an early childhood home visiting program, uses community health workers (CHWs) to improve health outcomes in underserved communities. Methods: This randomized clinical trial evaluated the impact of MIHOW's use of CHWs on selected maternal/infant outcomes up to 15 months postpartum. We hypothesized outcomes would be better among Hispanic women receiving MIHOW compared to a similar group of women eligible for MIHOW who received only a minimal education intervention (MEI). The study also expanded earlier research testing MIHOW's efficacy among Hispanic families using criteria set forth by federal guidelines. Women living in middle Tennessee enrolled during pregnancy (≤26 weeks gestation) and continued through 15 months postpartum. Results: Enrolled women (N = 132) were randomly assigned, with 110 women completing the study (MEI = 53; MIHOW = 57). Positive and statistically significant (p < .01) effects of MIHOW were observed on breastfeeding duration, safe sleep practices, stress levels, depressive symptoms, emotional support, referral follow through, parental confidence, and infant stimulation in the home. Conclusions: Findings provided strong evidence of the effectiveness of MIHOW for improving health outcomes in this sample. Using trained CHWs makes programs such as MIHOW a viable option for providing services to immigrant and underserved families.
Clinical Outcomes of Acute Respiratory Failure Associated With Noninvasive and Invasive Ventilation in a Pediatric ICU

BACKGROUND: It remains unknown if pediatric patients failing initial noninvasive ventilation (NIV) experience worse clinical outcomes than those successfully treated with NIV or those primarily intubated. METHODS: This was a single-center, retrospective review of patients admitted with acute respiratory failure to the University of Michigan pediatric intensive care or cardiothoracic ICUs and receiving NIV or invasive mechanical ventilation as first-line therapy. RESULTS: One hundred seventy subjects met inclusion criteria and were enrolled: 65 NIV success, 55 NIV failure, and 50 invasive mechanical ventilation alone. Of those failing NIV, median time to intubation was 1.8 (interquartile range [IQR] < 1–7) h. On multivariable regression, ICU-free days were significantly different between groups (NIV success: 22.9 ± 6.9 d; NIV failure: 13.0 ± 6.6 d; invasive ventilation: 12.5 ± 6.9 d; P < .001 across all groups). Multivariable regression revealed no difference in ventilator-free days between NIV failure and invasive ventilation groups (15.4 ± 10.1 d vs 15.9 ± 9.7 d, P = .71). Of 64 subjects (37.6%) meeting Pediatric Acute Lung Injury Consensus Conference pediatric ARDS criteria, only 14% were successfully treated with NIV. Ventilator-free days were similar between the NIV failure and invasive ventilation groups (11.6 vs 13.2 d, P = .47). On multivariable analysis, ICU-free days were significantly different across pediatric ARDS groups (P < .001): NIV success: 20.8 + 31.7 d; NIV failure: 8.3 + 23.8 d; invasive alone: 8.9 + 23.9 d, yet no significant difference in ventilator-free days between those with NIV failure versus invasive alone (11.6 vs 13.2 d, P = .47). CONCLUSIONS: We demonstrated that critically ill pediatric subjects unsuccessfully trialed on NIV did not experience increased ICU length of stay or fewer ventilator-free days when compared to those on invasive mechanical ventilation alone, including in the pediatric ARDS subgroup. Our findings are predicated on a median time to intubation of < 2 h in the NIV failure group and the provision of adequate monitoring while on NIV.
Data Set for the Reporting of Carcinomas of the Vulva: Recommendations From the International Collaboration on Cancer Reporting (ICCR)

A cogent and comprehensive pathologic report is essential for optimal patient management, cancer staging, and prognostication. This article details the International Collaboration on Cancer Reporting (ICCR) process and the development of the vulval carcinoma reporting data set. It describes the “core” and “noncore” elements to be included in pathology reports for vulval carcinoma, inclusive of clinical, macroscopic, microscopic, and ancillary testing considerations. It provides definitions and commentary for the evidence and/or consensus-based deliberations for each element included in the data set. The commentary also discusses controversial issues, such as p16/human papillomavirus testing, tumor grading and measurements, as well as elements that show promise and warrant further evidence-based study. A summary and discussion of the updated vulval cancer staging system by the International Federation of Obstetricians and Gynaecologists (FIGO) in 2021 is also provided. We hope the widespread implementation of this data set will facilitate consistent and accurate reporting, data collection, comparison of epidemiological and pathologic parameters between different populations, facilitate research, and serve as a platform to improve patient outcomes.
Exploring the characteristics and most bothersome symptoms in MECP2 duplication syndrome to pave the path toward developing parent‐oriented outcome measures

MECP2 Duplication Syndrome (MDS), resulting from the duplication of Xq28 region, including MECP2, is a rare disorder with a nascent understanding in clinical features and severity. Studies using antisense oligonucleotides revealed a broad phenotypic rescue in transgenic mice. With human clinical trials on the horizon, there is a need to develop clinical outcome measures for MDS.
Acute Generalized Exanthematous Pustulosis Associated With a COVID-19 Infection

ISSN: 0891-3668/22/4109-e406 DOI: 10.1097/INF.0000000000003604 Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. The authors have no funding or conflicts of interest to disclose. Address for correspondence: Meltem Polat, MD, Department of Paediatric Infectious Diseases, Gazi University School of Medicine, Ankara, Turkey. E-mail: meltemtemizhan@gmail.com. Acute Generalized Exanthematous Pustulosis Associated With a COVID-19 Infection