Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Factors for Positive Margins in Breast-Conserving Surgery

Introduction Breast-conserving surgery (BCS) followed by adjuvant radiotherapy has similar overall survival compared to mastectomy but is associated with higher rates of local recurrence. Positive surgical margins in BCS are the most important predictor of local recurrence. The aim of our study was to assess the risk factors associated with positive margins in women undergoing BCS for breast cancer in order to inform our clinical practice and minimize re-operation rates. Methods Patients with a diagnosis of breast cancer who underwent BCS from January 2013 to January 2021 were identified from our pathology database and included in the study. All patients underwent a lumpectomy with the removal of additional shaved cavity margins. Statistical analysis was used to assess the effect of patient clinical and pathological risk factors on the rate of positive margins. Results One hundred and twenty patients underwent BCS for breast cancer. Twenty-four percent of patients had positive margins. Of the 29 patients that underwent subsequent re-excisions, only 13 (45%) had residual disease in the re-excision specimen. In younger patients, tumors localized in lower quadrants and the presence of extensive intraductal component within invasive breast cancer increased the risk of positive margins. In addition, positive margins were encountered more significantly in patients with ductal carcinoma in situ (DCIS) compared to invasive tumors. Multivariate analysis showed that DCIS and young age were the only factors independently associated with positive margins. Conclusion DCIS and younger patients have a higher rate of positive margins during BCS than invasive breast cancer. For such patients at higher risk of positive margins, excision of cavity shave margins and intraoperative inking may be done to lower positive margin rates. Preoperative review of breast imaging, core biopsies, and counseling of patients about the likelihood of positive margins is important.
Study of the sediment transport over flat and wavy bottom using large-eddy simulation

In the present paper the sensitivity of the flow and of sediment transport to bottom roughness is studied. First, a thorough numerical investigation of smooth-bottom channel flow at Re τ = 395 is performed using large-eddy simulations (LESs). A dynamic version of the wall-adapted local eddy-viscosity (WALE) model is used for this study, whereas the subgrid-scale (sgs) diffusion stress is based on a gradient hypothesis. The computed results compare well with direct numerical simulation (DNS) data and experiments. Next, rough-bottom cases, with the bottom having a sinusoidal, wavy shape are considered. It was found that the wavy bottom has a strong influence on the flow field and that the sediment transport is highly sensitive to the bottom waviness, in particular for larger wave heights. It is shown that for light and low-concentrated sediment the Rouse theory is also valid in the case of a wavy bottom, mainly in the outer zone. Finally, it is found that the turbulent-Schmidt-number profiles are not very sensitive to the wave height.
Bipolar Chronobiology in Men and Mice: A Narrative Review

In patients with bipolar disorder, we do not only see a cycling of mood episodes, but also a shift in circadian rhythm. In the present overview, the circadian rhythm, the “internal clock”, and their disruptions are briefly described. In addition, influences on circadian rhythms such as sleep, genetics, and environment are discussed. This description is conducted with a translational focus covering human patients as well as animal models. Concluding the current knowledge on chronobiology and bipolar disorder, implications for specificity and the course of bipolar disorder and treatment options are given at the end of this article. Taken together, circadian rhythm disruption and bipolar disorder are strongly correlated; the exact causation, however, is still unclear.
Internet of Things (IoT) Based Cost Effective Weather Monitoring Station

The cost-effective weather station proposed here adopts a new practical approach for monitoring the weather conditions at different places and sharing the meteorological data anywhere across the globe. The main feature of the proposed work is the inclusion of Air Quality Index monitoring, it also sends the information to the cloud server. Internet of Things (IoT) is a network of various devices connected together to a system which extracts data from them and utilizes that data for various purposes.
Influence of Age on Associations of Occlusal Status and Number of Present Teeth with Dementia in Community-Dwelling Older People in Japan: Cross-Sectional Study

While occlusal status has been reported to be related to cognitive function, little is known about the influence of age on that relationship. The present study examined the associations of tooth loss and occlusal status with dementia in the older people, as well as the effects of age on those relationships. A total of 196 older participants (median age: 84 years) were enrolled. Occlusal status was assessed using functional tooth units (FTU), calculated based on the number of paired natural or artificial teeth. Logistic regression analysis was then performed using dementia as the objective variable, and FTU or number of teeth as explanatory variables. The results showed that higher FTU was associated with lower risk of dementia. Furthermore, when stratified by median age, the association was greater for those aged less than 84 years. On the other hand, there was no significant association of number of present teeth with dementia. These results suggest that the risk of dementia is lower for individuals with better occlusion and that occlusal factor may have a greater effect on dementia onset in younger older people. It is thus recommended that both occlusal function and age be incorporated as factors in programs developed for dementia prevention.
Lightweight Visual Transformers Outperform Convolutional Neural Networks for Gram-Stained Image Classification: An Empirical Study

We aimed to automate Gram-stain analysis to speed up the detection of bacterial strains in patients suffering from infections. We performed comparative analyses of visual transformers (VT) using various configurations including model size (small vs. large), training epochs (1 vs. 100), and quantization schemes (tensor- or channel-wise) using float32 or int8 on publicly available (DIBaS, n = 660) and locally compiled (n = 8500) datasets. Six VT models (BEiT, DeiT, MobileViT, PoolFormer, Swin and ViT) were evaluated and compared to two convolutional neural networks (CNN), ResNet and ConvNeXT. The overall overview of performances including accuracy, inference time and model size was also visualized. Frames per second (FPS) of small models consistently surpassed their large counterparts by a factor of 1-2×. DeiT small was the fastest VT in int8 configuration (6.0 FPS). In conclusion, VTs consistently outperformed CNNs for Gram-stain classification in most settings even on smaller datasets.
Clinical and Angiographic Profile in Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) and Chronic Stable Angina: A Tertiary Care Centre-Based Cohort Study From Southern Indian Population

Purpose This study aimed to assess the clinico-demographic profile, risk factors, and pattern of coronary involvement in non-ST elevation acute coronary syndrome (NSTE-ACS) and chronic stable angina (CSA). Methods This was a retrospective study conducted in a tertiary care hospital catering mainly to the rural population in Southern India from January 2020 to July 2022. Data from 333 patients with NSTE-ACS and CSA were analyzed during the study period for the clinico-demographic profile, risk factors, and pattern of coronary involvement in angiography. Results The mean age at presentation was 56.05±9.31. Significant obstructive coronary artery disease was present in 234 (70.3%) patients. Overall, single, double, and triple vessel disease occurred in 26%, 20%, and 32.4% of patients with NSTE-ACS and chronic stable angina. Sixty percent of the diabetic and hypertensive patients (n=92/153) had multivessel involvement. Left main coronary artery disease was present in 40 patients (12%). Conclusion Unstable angina was the most common clinical presentation. Left anterior descending (LAD) was the most common coronary vessel to be involved with occurrence of triple vessel disease in 32% of the study population. Multivessel involvement was more common in the diabetic and hypertensive groups.
Decellularized Scaffolds of Nopal (Opuntia Ficus-indica) for Bioengineering in Regenerative Dentistry

Opuntia Ficus-indica, or nopal, is traditionally used for its medicinal properties in Mexico. This study aims to decellularize and characterize nopal (Opuntia Ficus-indica) scaffolds, assess their degradation and the proliferation of hDPSC, and determine potential pro-inflammatory effects by assessing the expression of cyclooxygenase 1 and 2 (COX-1 and 2). The scaffolds were decellularized using a 0.5% sodium dodecyl sulfate (SDS) solution and confirmed by color, optical microscopy, and SEM. The degradation rates and mechanical properties of the scaffolds were determined by weight and solution absorbances using trypsin and PBS and tensile strength testing. Human dental pulp stem cells (hDPSCs) primary cells were used for scaffold–cell interaction and proliferation assays, as well as an MTT assay to determine proliferation. Proinflammatory protein expression of COX-I and -II was discovered by Western blot assay, and the cultures were induced into a pro-inflammatory state with interleukin 1-β. The nopal scaffolds exhibited a porous structure with an average pore size of 252 ± 77 μm. The decellularized scaffolds showed a 57% reduction in weight loss during hydrolytic degradation and a 70% reduction during enzymatic degradation. There was no difference in tensile strengths between native and decellularized scaffolds (12.5 ± 1 and 11.8 ± 0.5 MPa). Furthermore, hDPSCs showed a significant increase in cell viability of 95% and 106% at 168 h for native and decellularized scaffolds, respectively. The combination of the scaffold and hDPSCs did not cause an increase in the expression of COX-1 and COX-2 proteins. However, when the combination was exposed to IL-1β, there was an increase in the expression of COX-2. This study demonstrates the potential application of nopal scaffolds in tissue engineering and regenerative medicine or dentistry, owing to their structural characteristics, degradation properties, mechanical properties, ability to induce cell proliferation, and lack of enhancement of pro-inflammatory cytokines.
An Energy-Efficient StEFCal VLSI Design with Approximate Squarer and Divider Units

Approximate computing attempts to maximize area and energy savings for a trade-off between quality and efficiency. This paper investigates the approximate squarer and divider units in the calibration procedure for radio astronomy called StEFCal (Statistically Efficient and Fast Calibration). The StEFCal circuit uses two squarer units from the literature, i.e., radix-4 (AxRSU) and SquASH, and iterative-based Newton-Raphson (NR) and Goldschmid (GLD) dividers. We demonstrate the efficiency of StEFCal using the approximate arithmetic operators from the Pareto-optimal that show the area- and power-quality trade-off. The results show that using the AxRSU combined with the NR divider improves the Mean Square Error (MSE) by 4.24%, with 58x more energy saving than the state-of-the-art.
Long term post-traumatic stress disorders among the earthquake affected people of Sindhupalchwok, Nepal

Background: People who are suffering from PTSD have disturbing feelings and thoughts which is related to their experience even after a long time of such traumatic events happened. This study highlight the characteristics and prevalence of PTSD among the earthquake survivors.Methods: Cross sectional study was carried out using standard PCL-5 PTSD questionnaire. Interview was taken among 376 survivors of earthquake after 4 years of earthquake in Sindhupalchok. Descriptive statistics, Chi-square test and multiple logistic regression were used to describe data and test association.Results: The mean age of the respondents was 39.47±16.18 years. Almost 2/5th of the respondents were either buried, injured or physically or mentally disabled during earthquake. Majority of the survivors had loss their loved one while most of them loss their property. Among the respondents who were buried 28.6% had develop PTSD which was 22.2% among physical or mental disable during earthquake. PTSD showed significant association with age, loss of known person and loss of property however didn’t show with gender, caste, experience of earthquake and so on. The prevalence of PTSD was 71 (21.5%) out of 331 respondents. Female (63.4%) were more prone to PTSD than male (36.6%). Conclusions: PTSD is prevalent among 21.5% of survivors even after 4 years of earthquake which showed an urgent need to address PTSD among the respondents and immediate intervention to prevent and treat such problems in case of future disasters.
UI Binding Transfer for Bone-driven Facial Rigs

We propose an automatic method to transfer the UI binding from a rigged model to a new target mesh. We use feed forward neural net-works to find the mapping functions between bones and controllers of source model. The learned mapping networks then become the initial weights of an auto-encoder. Then the auto-encoder is retrained using target controllers-bones pairs obtained by the mesh transfer and bones decoupling method. Our system only requires neutral expression of the target person but allows artists to customize other basic expressions, and is evaluated by the semantic reproducibility of basic expressions and the semantic similarity.
Postoperative Complications following Open Reduction and Rigid Internal Fixation of Mandibular Condylar Fracture Using the High Perimandibular Approach

The high perimandibular approach is a feasible surgical technique for treating mandibular condylar fractures with open reduction and internal fixation, followed by fewer complications. Temporary trismus is the only postoperative complication that may occur. This study evaluated postoperative complications following open reduction and rigid internal fixation (OR-IF) of mandibular condylar fractures using the high perimandibular approach. Twenty consecutive patients undergoing OR-IF were included in this study. They included 11 male and 9 female patients, of an average age of 58.5 years, all of whom responded to a follow-up call at least 12 months after the surgery. All patients were evaluated for range of mouth opening, postoperative complications, and radiological findings. A statistical analysis of the relationship between range of mouth opening and related clinical parameters at 6 months postoperative evaluation was conducted. The fracture of the condylar neck was associated with a limited range of mouth opening and longer operation time. However, longer operation time was not associated with a limited range of mouth opening. The high perimandibular approach with OR-IF in mandibular condylar fractures is a feasible and safe technique; however, prolonged surgery and mandibular condylar neck fractures could affect the postoperative range of mouth opening.
Life Cycle Characteristics of MCSs in Middle East China Tracked by Geostationary Satellite and Precipitation Estimates

AbstractBy combining high temporal and spatial resolution Multifunctional Transport Satellite-1R (MTSAT-1R) infrared (IR) images and precipitation data from the Climate Prediction Center morphing technique (CMORPH), this study tracked mesoscale convective systems (MCSs) from May to August in 2008 and 2009 in the middle of east China with an automatic tracking algorithm based on an areal overlapping methodology. This methodology is adjusted to include those MCSs with a relative weak intensity before formation. The unique advantage of combining high temporal and spatial resolution geostationary satellite brightness temperature images and the precipitation measurements for tracking MCSs is that the cloud-top height along with the coverage and the precipitation intensity can be well identified. Results showed that the MCSs formed most frequently in the southwest Henan Province and at the border of four provinces—Shandong, Henan, Anhui, and Jiangsu—which is east of the convergence zone near the terrain’s edge.
Preventing Lower Limb Graft Thrombosis after Infrainguinal Arterial Bypass Surgery with Antithrombotic Agents (PATENT Study): An International Expert Based Delphi Consensus

(1) Background: High-level evidence on antithrombotic therapy after infrainguinal arterial bypass surgery in specific clinical scenarios is lacking. (2) Methods: A modified Delphi procedure was used to develop consensus statements. Experts voted on antithrombotic treatment regimens for three types of infrainguinal arterial bypass procedures: above-the-knee popliteal artery; below-the-knee popliteal artery; and distal, using vein, prosthetic, or biological grafts. The treatment regimens for these nine procedures were then voted on in three clinical scenarios: isolated PAOD, atrial fibrillation, and recent coronary intervention. (3) Results: The survey was conducted with 28 experts from 15 European countries, resulting in consensus statements on 25/27 scenarios. Experts recommended single antiplatelet therapy after above-the-knee popliteal artery bypasses regardless of the graft material used. For below-the-knee popliteal artery bypasses, experts suggested combining single antiplatelet therapy with low-dose rivaroxaban if the graft material used was autologous or biological. They did not recommend switching to triple therapy for patients on oral anticoagulants for atrial fibrillation or dual antiplatelet therapy in any scenario. (4) Conclusions: Great inconsistency in the antithrombotic therapy administered was found in this study. This consensus offers guidance for scenarios that are not covered in the current ESVS guidelines but must be interpreted within its limitations.
Predictive Value of MUC5AC Signature in Pancreatic Ductal Adenocarcinoma: A Hypothesis Based on Preclinical Evidence

Mucin 5AC (MUC5AC) glycoprotein plays a crucial role in carcinogenesis and drug sensitivity in pancreatic ductal adenocarcinoma (PDAC), both individually and in combination with other mucins. Its function and localization are glycoform-specific. The immature isoform (detected by the CLH2 monoclonal antibody, or mab) is usually in the perinuclear (cytoplasmic) region, while the mature (45 M1, 2-11, Nd2) variants are in apical and extracellular regions. There is preclinical evidence suggesting that mature MUC5AC has prognostic and predictive (response to treatment) value. However, these findings were not validated in clinical studies. We propose a MUC5AC signature with three components of MUC5AC—localization, variant composition, and intensity—suggesting a reliable marker in combination of variants than with individual MUC5AC variants alone. We also postulate a theory to explain the occurrence of different MUC5AC variants in abnormal pancreatic lesions (benign, precancerous, and cancerous). We also analyzed the effect of mature MUC5AC on sensitivity to drugs often used in PDAC management, such as gemcitabine, 5-fluorouracil, oxaliplatin, irinotecan, cisplatin, and paclitaxel. We found preliminary evidence of its predictive value, but there is a need for large-scale studies to validate them.
O( p logn) approximation to SPARSEST CUT can be found in

We show that the recent results for obtaining O( p logn)-approximation to sparsest cut and bal- anced separator problems due to Arora, Rao, and Vazirani (2004) can be used to derive an ~ O(n 2 ) time approximation algorithm for an n-node graph. The previous best algorithm needed to solve a semideflnite program with O(n 3 ) constraints. Our algorithm relies on e-ciently flnding expander ∞ows in the graph. The existence of these ∞ows was established by (ARV).
EGG Objective characterization of cybersickness symptoms towards navigation axis

The current study sought to objectively evaluate cybersickness by utilizing Electrogastrogram (EGG) physiological data in relation to three different navigation axes: Translational movement along the longitudinal and lateral axes, and rotation along the vertical Yaw axis. EGG was employed as it has been clinically identified as a valuable tool for capturing dysfunction in the stomach. This resulted in a 2x2x2 factorial design. Results from both subjective and objective measurements $(\mathrm{N}=26,\ \mathrm{F}=10)$ indicate that rotation along the Yaw axis is the primary factor influencing cybersickness. Additionally, it was found that individuals who are not susceptible to cybersickness do not exhibit any dominant factors. In summary, through the analysis of EGG data, several key physi-ological indicators of individual susceptibility to cybersickness were identified. The findings suggest that there is a positive correlation between the mean dominant frequency and the tachygastria ratio with individual susceptibility, while the normalgastria and normal-tachy ratio were found to be negatively correlated with individual susceptibility
Design of a Low-Cost Diffuse Optical Mammography System for Biomedical Image Processing in Breast Cancer Diagnosis

Worldwide, breast cancer is the most common type of cancer that mainly affects women. Several diagnosis techniques based on optical instrumentation and image analysis have been developed, and these are commonly used in conjunction with conventional diagnostic devices such as mammographs, ultrasound, and magnetic resonance imaging of the breast. The cost of using these instruments is increasing, and developing countries, whose deaths indices due to breast cancer are high, cannot access conventional diagnostic methods and have even less access to newer techniques. Other studies, based on the analysis of images acquired by traditional methods, require high resolutions and knowledge of the origin of the captures in order to avoid errors. For this reason, the design of a low-cost diffuse optical mammography system for biomedical image processing in breast cancer diagnosis is presented. The system combines the acquisition of breast tissue photographs, diffuse optical reflectance (as a biophotonics technique), and the processing of digital images for the study and diagnosis of breast cancer. The system was developed in the form of a medical examination table with a 638 nm red-light source, using light-emitted diode technology (LED) and a low-cost web camera for the acquisition of breast tissue images. The system is automatic, and its control, through a graphical user interface (GUI), saves costs and allows for the subsequent analysis of images using a digital image-processing algorithm. The results obtained allow for the possibility of planning in vivo measurements. In addition, the acquisition of images every 30° around the breast tissue could be used in future research in order to perform a three-dimensional (3D) reconstruction and an analysis of the captures through deep learning techniques. These could be combined with virtual, augmented, or mixed reality environments to predict the position of tumors, increase the likelihood of a correct medical diagnosis, and develop a training system for specialists. Furthermore, the system allows for the possibility to develop analysis of optical characterization for new phantom studies in breast cancer diagnosis through bioimaging techniques.