Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle

Mentha spicata is one of the most popular species in the genus, and it is of great interest as a gastrointestinal and sedative agent in the folk medicine system. In this study, different M. spicata extracts, obtained by the use of four solvents (hexane, chloroform, acetone and acetone/water) were chemically characterized using HPLC-ESI-MS n, which allowed for identification of 27 phenolic compounds. The extracts’ antioxidant and enzyme inhibitory properties were investigated. In addition, neuroprotective effects were evaluated in hypothalamic HypoE22 cells, and the ability of the extracts to prevent the hydrogen peroxide-induced degradation of dopamine and serotonin was observed. The best antioxidant effect was achieved for all the extraction methods using acetone/water as a solvent. These extracts were the richest in acacetin, eriodictyol, hesperidin, sagerinic acid, naringenin, luteolin, chlorogenic acid, chrysoeriol and apigenin. The intrinsic antioxidant and enzyme inhibition properties of the acetone/water extract could also explain, albeit partially, its efficacy in preventing prostaglandin E2 overproduction and dopamine depletion (82.9% turnover reduction) in HypoE22 cells exposed to hydrogen peroxide. Thus, our observations can provide a scientific confirmation of the neuromodulatory and neuroprotective effects of M. spicata.
Effects of Restricted Feeding on Growth Performance, Intestinal Immunity, and Skeletal Muscle Development in New Zealand Rabbits

Simple Summary The high prevalence of gastrointestinal diseases in young rabbits is the major cause of impediment in the development of the rabbit industry. Presently, few companies have adopted methods of restricting feeding to improve the survival rate independent of the effect on their growth and development. To explore the effects of different feeding-restriction levels on the growth performance, intestinal immunity, and skeletal muscle development of meat rabbits, 198 New Zealand meat rabbits of 35 days old were selected and randomly divided into three groups: (1) a control group, (2) a 15% feeding restriction group, and (3) a 30% feeding restriction group, with 66 in each group with an equal number of males and females. The growth performance measurement and health-risk assessment indicators, measurement of digestive enzyme activity, immune and antioxidant indexes, and regulation mechanism were evaluated and explored. Finally, we found that a 30% feeding limit affected the growth and development of skeletal muscle in growing rabbits by regulating the PI3K/Akt signaling pathway. Abstract This study aimed to explore the effects of different feeding restriction levels on the growth performance, intestinal immunity, and skeletal muscle development of meat rabbits. Additionally, we studied whether complete compensatory growth could be obtained post 2 weeks of restricted feeding, in order to seek a scientific mode of feeding restriction. Each of three groups was exposed to 3 weeks of feeding restriction and 2 weeks of compensatory growth. The 15% feeding restriction showed a negligible effect on the final body-weight of the rabbits (p > 0.05), but significantly reduced the feed-to-weight ratio (p < 0.05); reduced diarrhea and mortality; and increased digestive enzyme activity and antioxidant capacity. However, a 30% feeding-restriction level substantially reduced the growth rate of the rabbits (p < 0.05), impaired skeletal muscle development, and showed no compensatory growth after 2 weeks of nutritional recovery. Additionally, immunoglobulin and antioxidant enzyme synthesis were impaired due to reduced nutritional levels, and levels of pro-inflammatory factors were increased during the compensation period. The IGF1 mRNA expression decreased significantly (p < 0.05), whereas MSTN and FOXO1 expression increased noticeably (p < 0.05). Moreover, protein levels of p-Akt and p-p70 decreased significantly in the 15% feeding restriction group. Overall, the 15% feeding limit unaffected the weight and skeletal muscle development of rabbits, whereas the 30% feeding limit affected the growth and development of skeletal muscle in growing rabbits. The PI3K/Akt signaling pathway is plausibly a mediator of this process.
Introducing realistic tire–pavement contact stresses into Pavement Analysis using Nonlinear Damage Approach (PANDA)

Abstract Realistic tire–pavement interface contact areas and stresses were incorporated into the Pavement Analysis using Nonlinear Damage Approach (PANDA) user interface (PUI). PANDA is a software library developed to simulate the complex thermo-viscoelastic–viscoplastic–viscodamage responses of the pavement to mechanical and environmental loads. The PUI is an interface generating a finite element representation of the pavement within PANDA. The application of realistic tire loading is necessary to calculate accurate pavement responses. The PUI incorporates a database of tire contact areas and stresses obtained from tire finite element simulations. The database includes tire interface characteristics with pavements for various applied loads, tire inflation pressures, vehicle speeds and scenarios of different rolling simulations. A parametric study was conducted to investigate the effect of simulations of tire contact stresses that match field measurements on viscoelastic and viscoplastic pavement responses. Pavement responses are greatly affected using realistic tire loading contact stresses and contact geometry as compared to simplified contact models. The impact on rutting and damage predictions cannot be ignored if reliable projections of pavement performance are to be made. This study confirms the importance of considering realistic three-dimensional contact stresses to design and analyse pavements.
Missing Work Is a Pain: The Effect of Cox-2 Inhibitors on Sickness Absence and Disability Pension Receipt

ABSTRACT:How does medical innovation affect labor supply? We analyze how the availability of Cox-2 inhibitors, pharmaceuticals used for treating pain and inflammation, affected the sickness absence and disability pension receipt of individuals with joint pain. We exploit the market entry of the Cox-2 inhibitor Vioxx and its sudden market withdrawal as exogenous sources of variation in drug use. Using Norwegian administrative data, we find Vioxx's entry decreased quarterly sickness absence days among individuals with joint pain by 7–12 percent. The withdrawal increased sickness days by 12–16 percent and increased the quarterly probability of receiving disability benefits by 6–15 percent.
Was That SMART?: Institutional Financial Incentives and Field of Study

We examine whether students respond to immediate financial incentives when choosing their college major. From 2006–2007 to 2010–2011, low-income students in technical or foreign language majors could receive up to $8,000 in SMART Grants. Since income-eligibility was determined using a strict threshold, we determine the causal impact of this grant on student major with a regression discontinuity design. Using administrative data from public universities in Texas, we determine that income-eligible students were 3.2 percentage points more likely than their ineligible peers to major in targeted fields. We measure a larger impact of 10.2 percentage points at Brigham Young University.
Algorithms for Estimating Time-Locked Neural Response Components in Cortical Processing of Continuous Speech

Objective The Temporal Response Function (TRF) is a linear model of neural activity time-locked to continuous stimuli, including continuous speech. TRFs based on speech envelopes typically have distinct components that have provided remarkable insights into the cortical processing of speech. However, current methods may lead to less than reliable estimates of single-subject TRF components. Here, we compare two established methods, in TRF component estimation, and also propose novel algorithms that utilize prior knowledge of these components, bypassing the full TRF estimation. Methods We compared two established algorithms, ridge and boosting, and two novel algorithms based on Subspace Pursuit (SP) and Expectation Maximization (EM), which directly estimate TRF components given plausible assumptions regarding component characteristics. Single-channel, multi-channel, and source-localized TRFs were fit on simulations and real magnetoencephalographic data. Performance metrics included model fit and component estimation accuracy. Results Boosting and ridge have comparable performance in component estimation. The novel algorithms outperformed the others in simulations, but not on real data, possibly due to the plausible assumptions not actually being met. Ridge had slightly better model fits on real data compared to boosting, but also more spurious TRF activity. Conclusion Results indicate that both smooth (ridge) and sparse (boosting) algorithms perform comparably at TRF component estimation. The SP and EM algorithms may be accurate, but rely on assumptions of component characteristics. Significance This systematic comparison establishes the suitability of widely used and novel algorithms for estimating robust TRF components, which is essential for improved subject-specific investigations into the cortical processing of speech.
Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis

An association between age-related hearing loss (ARHL) and Alzheimer's Disease (AD) has been widely reported. However, the nature of this relationship remains poorly understood. Quantification of hearing loss as it relates to AD is imperative for the creation of reliable, hearing-related biomarkers for earlier diagnosis and development of ARHL treatments that may slow the progression of AD. Previous studies that have measured the association between peripheral hearing function and AD have yielded mixed results. Most of these studies have been small and underpowered to reveal an association. Therefore, in the current report, we sought to estimate the degree to which AD patients have impaired hearing by performing a meta-analysis to increase statistical power. We reviewed 248 published studies that quantified peripheral hearing function using pure-tone audiometry for subjects with AD. Six studies, with a combined total of 171 subjects with AD compared to 222 age-matched controls, met inclusion criteria. We found a statistically significant increase in hearing threshold as measured by pure tone audiometry for subjects with AD compared to controls. For a three-frequency pure tone average calculated for air conduction thresholds at 500–1,000–2,000 Hz (0.5–2 kHz PTA), an increase of 2.3 decibel hearing level (dB HL) was found in subjects with AD compared to controls (p = 0.001). Likewise, for a four-frequency pure tone average calculated at 500–1,000–2,000–4,000 (0.5–4 kHz PTA), an increase of 4.5 dB HL was measured (p = 0.002), and this increase was significantly greater than that seen for 0.5–2 kHz PTA. There was no difference in the average age of the control and AD subjects. These data confirm the presence of poorer hearing ability in AD subjects, provided a quantitative estimate of the magnitude of hearing loss, and suggest that the magnitude of the effect is greater at higher sound frequencies. Systematic Review Registration: https://www.crd. york.ac. uk/prospero/, identifier: CRD42021288280.
Decoupling Oxygen Tension From Retinal Vascularization as a New Perspective for Management of Retinopathy of Prematurity. New Opportunities From β-adrenoceptors

Retinopathy of prematurity (ROP) is an evolutive and potentially blinding eye disease that affects preterm newborns. Unfortunately, until now no conservative therapy of active ROP with proven efficacy is available. Although ROP is a multifactorial disease, premature exposition to oxygen concentrations higher than those intrauterine, represents the initial pathogenetic trigger. The increase of oxygenation in a retina still incompletely vascularized promotes the downregulation of proangiogenic factors and finally the interruption of vascularization (ischemic phase). However, the increasing metabolic requirement of the ischemic retina induces, over the following weeks, a progressive hypoxia that specularly increases the levels of proangiogenic factors finally leading to proliferative retinopathy (proliferative phase). Considering non-modifiable the coupling between oxygen levels and vascularization, so far, neonatologists and ophthalmologists have “played defense”, meticulously searching the minimum necessary concentration of oxygen for individual newborns, refining their diagnostic ability, adopting a careful monitoring policy, ready to decisively intervene only in a very advanced stage of disease progression. However, recent advances have demonstrated the possibility to pharmacologically modulate the relationship between oxygen and vascularization, opening thus the perspective for new therapeutic or preventive opportunities. The perspective of a shift from a defensive towards an attack strategy is now at hand.
Fuzzy or Clear? A Computational Approach Towards Dynamic L2 Lexical-Semantic Representation

In this paper, we present a computational approach to bilingual speakers’ non-native (L2) lexical-semantic representations. Specifically, based on detailed analyses of the error patterns shown in our previous simulation results (Zhao and Li Int. J. Bilingual. Educ. Bilingual., 2010, 13, 505–524; Zhao and Li, Bilingualism, 2013, 16, 288–303), we aim at revealing the underlying learning factors that may affect the extent of fuzzy category boundaries within bilinguals’ L2 representation. Here, we first review computational bilingual models in the literature that have focused on simulating L2 lexical representations, including the Developmental Lexicon II (DevLex-II) model (Zhao and Li, Int. J. Bilingual. Educ. Bilingual., 2010, 13, 505–524; Zhao and Li, Bilingualism, 2013, 16, 288–303), on which the current study is based. The DevLex-II modeling results indicate a strong age of acquisition (AoA) effect: When the learning of L2 is early relative to that of native language (L1), functionally distinct lexical representations may be established for both languages; when the learning of L2 is significantly delayed relative to that of L1, fuzzy L2 representations may occur due to the structural consolidation (or the entrenchment) of the L1 lexicon. Next, we explore the error patterns shown in both lexical comprehension and production in DevLex-II. A novel contribution of the current study is that we systematically compare the computational simulation results with empirical findings. Such model-based error analyses extend our previous findings by indicating, especially in the late L2 learning condition, that fuzzy L2 semantic representations emerge and lead to processing errors, including errors in unstable phonology-semantic and semantic-phonemic mappings. The DevLex-II model provides a computational account of the development of bilinguals’ L2 representation with reference to the dynamic interaction and competition between the two lexicons. We point to future directions in which fuzzy L2 representations may be overcome, through a framework that highlights the social learning of L2 (SL2) and the embodied semantic representation of the lexicon in the new language (Li and Jeong, Npj Sci. Learn., 2020, 5, 1–9; Zhang, Yang, Wang and Li, Lang. Cogn. Neurosci., 2020, 35, 1223–1238).
Inducing Error Management Culture – Evidence From Experimental Team Studies

Field studies indicate that error management culture can be beneficial for organizational performance. The question of whether and how error management culture can be induced remained unanswered. We conducted two experiments with newly formed teams, in which we aimed to induce error management culture and to explore whether we would also find beneficial effects of error management culture on performance in an experimental setting. Furthermore, we tested whether culture strength moderates the relationship between error management culture and performance. In Study 1, we used two tasks that require rational problem solving. In Study 2, we used a task that requires creative problem solving. We successfully manipulated error management culture in terms of an effect on perceived error management culture within the teams. While we did not find a direct effect of error management culture on performance, Study 2 revealed an indirect effect via communication in the teams. To our surprise, culture strength did not influence the hypothesized relationship. We discuss potential theoretical and alternative explanations for our results, and provide an outlook for future studies.
A Vasopressin-Induced Change in Prostaglandin Receptor Subtype Expression Explains the Differential Effect of PGE2 on AQP2 Expression

Arginine vasopressin (AVP) stimulates the concentration of renal urine by increasing the principal cell expression of aquaporin-2 (AQP2) water channels. Prostaglandin E2 (PGE2) and prostaglandin2α (PGF2α) increase the water absorption of the principal cell without AVP, but PGE2 decreases it in the presence of AVP. The underlying mechanism of this paradoxical response was investigated here. Mouse cortical collecting duct (mkpCCDc14) cells mimic principal cells as they endogenously express AQP2 in response to AVP. PGE2 increased AQP2 abundance without desmopressin (dDAVP), while in the presence of dDAVP, PGE2, and PGF2α reduced AQP2 abundance. dDAVP increased the cellular PGD2 and PGE2 release and decreased the PGF2α release. MpkCCD cells expressed mRNAs for the receptors of PGE2 (EP1/EP4), PGF2 (FP), and TxB2 (TP). Incubation with dDAVP increased the expression of EP1 and FP but decreased the expression of EP4. In the absence of dDAVP, incubation of mpkCCD cells with an EP4, but not EP1/3, agonist increased AQP2 abundance, and the PGE2-induced increase in AQP2 was blocked with an EP4 antagonist. Moreover, in the presence of dDAVP, an EP1/3, but not EP4, agonist decreased the AQP2 abundance, and the addition of EP1 antagonists prevented the PGE2-mediated downregulation of AQP2. Our study shows that in mpkCCDc14 cells, reduced EP4 receptor and increased EP1/FP receptor expression by dDAVP explains the differential effects of PGE2 and PGF2α on AQP2 abundance with or without dDAVP. As the V2R and EP4 receptor, but not the EP1 and FP receptor, can couple to Gs and stimulate the cyclic adenosine monophosphate (cAMP) pathway, our data support a view that cells can desensitize themselves for receptors activating the same pathway and sensitize themselves for receptors of alternative pathways.
Transcriptome and Metabolome Integration Provides New Insights Into the Regulatory Networks of Tibetan Pig Alveolar Type II Epithelial Cells in Response to Hypoxia

Tibetan pigs show a widespread distribution in plateau environments and exhibit striking physiological and phenotypic differences from others pigs for adaptation to hypoxic conditions. However, the regulation of mRNAs and metabolites as well as their functions in the alveolar type II epithelial (ATII) cells of Tibetan pigs remain undefined. Herein, we carried out integrated metabolomic and transcriptomic profiling of ATII cells between Tibetan pigs and Landrace pigs across environments with different oxygen levels to delineate their signature pathways. We observed that the differentially accumulated metabolites (DAMs) and differentially expressed genes (DEGs) profiles displayed marked synergy of hypoxia-related signature pathways in either Tibetan pigs or Landrace pigs. A total of 1,470 DEGs shared between normoxic (TN, ATII cells of Tibetan pigs were cultured under 21% O2; LN, ATII cells of Landrace pigs were cultured under 21% O2) and hypoxic (TL, ATII cells of Tibetan pigs were cultured under 2% O2; LL, ATII cells of Landrace pigs were cultured under 2% O2) groups and 240 DAMs were identified. Functional enrichment assessment indicated that the hypoxia-related genes and metabolites were primarily involved in glycolysis and aldosterone synthesis and secretion. We subsequently constructed an interaction network of mRNAs and metabolites related to hypoxia, such as guanosine-3′, 5′-cyclic monophosphate, Gly-Tyr, and phenylacetylglycine. These results indicated that mitogen-activated protein kinase (MAPK) signaling, aldosterone synthesis and secretion, and differences in the regulation of MCM and adenosine may play vital roles in the better adaptation of Tibetan pigs to hypoxic environments relative to Landrace pigs. This work provides a new perspective and enhances our understanding of mRNAs and metabolites that are activated in response to hypoxia in the ATII cells of Tibetan pigs.
Metals, Nanoparticles, Particulate Matter, and Cognitive Decline

Exposure to metals is ubiquitous and emission sources include gasoline, diesel, smoke from wildfires, contaminated soil, water and food, medical implants, waste recycling facilities, subway exposures, and occupational environments. PM2.5 exposure is associated with impaired cognitive performance, neurobehavioral alterations, incidence of dementia, and Alzheimer's disease (AD) risk. Heavy-duty diesel vehicles are major emitters of metal-rich PM2.5 and nanoparticles in Metropolitan Mexico City (MMC). Cognitive impairment was investigated in 336 clinically healthy, middle-class, Mexican volunteers, age 29.2 ± 13.3 years with 13.7 ± 2.4 years of education using the Montreal Cognitive Assessment (MoCA). MoCA scores varied with age and residency in three Mexican cities with cognition deficits impacting ~74% of the young middle-class population (MoCA ≤ 25). MMC residents ≥31 years (x¯46.2 ± 11.8 y) had MoCA x¯20.4 ± 3.4 vs. low pollution controls 25.2 ± 2.4 (p < 0.0001). Formal education years positively impacted MoCA total scores across all participants (p < 0.0001). Residency in PM2.5 polluted cities impacts multi-domain cognitive performance. Identifying and making every effort to lower key pollutants impacting neural risk trajectories and monitoring cognitive longitudinal performance are urgent. PM2.5 emission control should be prioritized, metal emissions targeted, and neuroprevention interventions implemented early.