Miracle-dz/UniFAR-FTUs huggingface dataset:
The Associations of Genetic Variants in E-cadherin Gene With Clinical Outcome of Epithelial Ovarian Cancer.

OBJECTIVE The E-cadherin protein plays major roles in tumor progression, invasion, and metastasis. Polymorphisms located in the E-cadherin gene (CDH1) may contribute to increased risks of specific cancers. In this study, we evaluated the associations between genetic variants in CDH1 and the clinical outcomes of patients with epithelial ovarian cancer (EOC). MATERIALS AND METHODS We assessed the -160C/A and -347G/GA polymorphisms in the promoter region, as well as the 3'-UTR +54C/T polymorphism of E-cadherin, in 257 patients with EOC by ligase detection reaction-polymerase chain reaction. RESULTS Multivariate analysis showed that patients with EOC with the CDH1 -347GA/GA genotype had shorter progression-free survival and overall survival (hazard ratio [HR], 2.16; 95% confidence interval [CI], 1.06-4.40 and HR, 2.06; 95% CI, 1.01-4.19, respectively) compared to those carrying the G/G genotype. Likewise, the patients with the CDH1 -160A/A genotype had a shorter progression-free survival than those with the C/C genotype (HR, 4.12; 95% CI, 1.43-111.88). No significant association was detected between the CDH1 3'-UTR +54C/T polymorphism and survival of the patients with EOC. CONCLUSIONS The CDH1 -347GA/GA and -160A/A genotypes may be prognostic markers that can help to identify patients at increased risk of invasive/metastatic cancer in northern China.
High Resolution STEM-HAADF microscopy on γ -Al2O3 supported MoS2 catalyst – Proof by image of the changes in dispersion and morphology of the slabs with addition of citric acid.

Atomic-scale images of MoS 2 slabs supported on γ-Al 2 O 3 were obtained by High Resolution Scanning Transmission Electron Microscopy equipped with High Angular Annular Dark Field detector (HR STEM-HAADF). These observations, obtained for sulfide catalysts prepared without or with citric acid as chelating agent, evidenced variations in morphology (shape) and size of the MoS 2 nanoslabs, as detected indirectly by the adsorption of CO followed by Infrared spectroscopy. Quantitative dispersion values and a morphology index (S-edge/M-edge ratio) were determined from the slabs observed. In this way, HR STEM-HAADF underlines that the addition of citric acid to Mo catalysts decreases the size of the particles and modifies the shape of the MoS 2 nanoslabs from slightly truncated triangles to particles with a higher ratio of S-edge/M-edge. Furthermore, this work demonstrated that the IR/CO method is a relevant approach to describe MoS 2 morphology in industrial γ-Al 2 O 3
Tectonic significance of the Hellenic-Dinaric ophiolites

Abstract Isotopic and biostratigraphic data show the Hellenic ophiolites (those SE of the Scutari-Pec transform zone in Albania) are of Middle to Late Jurassic age. They are of two contrasting types. The first type of ophiolite is complete, usually harzburgitic, forms allochthonous sheets, commonly develops metamorphic soles, generally includes significant chrome deposits and shows supra-subduction zone (SSZ) trace-element characteristics with an evolution from MORB to IAT and occasionally boninites. The second type is characterized by incomplete ophiolites which lack chrome and mantle tectonite rocks. In contrast to the first type, these are slightly younger, are exposed in situ, show contact metamorphism against the country rock, are similar to MORB and show little influence of a subduction zone. The harzburgitic ophiolites from a western and an eastern outcrop belt. The relationship between the two is unclear, principally because of large, probably strike-slip, offsets in the Vardar zone, best documented in former Yugoslavia. The western Hellenic ophiolites (Pindos, Vourinos, Othris, Evvia ( = Euboea) and Argolis) all formed above a SW-dipping subduction zone in early Middle Jurassic time. They are continuous with a similar belt in the Dinarides of Yugoslavia whose SW margin gradually becomes lherzolitic as it is traced northwards. It is totally lherzolitic at its termination in NW Yugoslavia. This gradual change in ultramafic character is speculatively linked to the changes in spreading rates in a wedge-shaped marginal basin. Emplacement took place in later Middle to Late Jurassic time probably along a low-angle detachment zone that was close to the lithosphere/asthenosphere boundary shortly after spreading ceased. The SW half of the basin was pushed over the NE half, which was subducted to the SW but has left very little trace of its former existence. In the Hellenides the ophiolites were emplaced onto the Pelagonian continent and in the Dinarides onto the Drina-Ivanjica continent. Precise analogues of the complete ophiolites appear to be absent in the present-day major ocean basins — because of their SSZ character — or any island arcs that border the present-day oceans — because their marginal stratigraphy shows no trace of arc sediments or volcanics. The incomplete ophiolites, which appear to be restricted to the Axios zone in Greece, seem to be the expression of transient motion on short extensional segments of a plate margin whose geometry resembled the early stages of the opening of the Gulf of California.
Hydrological impact and potential flooding of convective rain cells in a semi-arid environment

Abstract t Spatio-temporal storm properties have a large impact on catchment hydrological response. The sensitivity of simulated flash floods to convective rain-cell characteristics is examined for an extreme storm event over a 94 km2 semi-arid catchment in southern Israel. High space–time resolution weather radar data were used to derive and model convective rain cells that then served as input into a hydrological model. Based on alterations of location, direction and speed of a major rain cell, identified as the flooding cell for this case, the impacts on catchment rainfall and generated flood were examined. Global sensitivity analysis was applied to identify the most important factors affecting the flash flood peak discharge at the catchment outlet. We found that the flood peak discharge could be increased three-fold by relatively small changes in rain-cell characteristics. We assessed that the maximum flash flood magnitude that this single rain cell can produce is 175 m3/s, and, taking into account the rest of the rain cells, the flash flood peak discharge can reach 260 m3/s. Editor Z.W. Kundzewicz; Guest editor R.J. Moore Citation Morin, E. and Yakir, H. , 2013. Hydrological impact and potential flooding of convective rain cells in a semi-arid environment. Hydrological Sciences Journal, 59 (7), 1275–1284. http://dx.doi. org/10.1080/02626667.2013. 841315
Surf Zone Longshore Currents and Random Waves: Field Data and Models

Abstract Analytic and numerical models for longshore currents generated by obliquely incident random waves am compared with field observations. Five days of observations were selected during which the waves were narrow banded in both frequency and direction, in keeping with model assumptions. The extensive measurements included radiation stress and wave directional spectra in 9 m depth, and a closely spaced array of current and pressure sensors on a line perpendicular to shore. The longshore current models are based on balancing the gradient of the radiation stress with the alongshore bed shear and Reynold's stresses, assuming stationary wave conditions and straight and parallel bottom contours. The spatial variation of wave height, required to determine the gradient of the radiation stress, is modeled using linear random wave theory. Given Hrms in 9 m depth, the model predicts Hrms at shoreward locations with an average error of less than 9%. Using a nonlinear bottom shear stress formulation and the meas.
Differential BDNF methylation in combat exposed veterans the association with exercise

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Measuring and Modeling Tree and Stand Level Transpiration

Transpiration is a key process in the application of phytoremediation to soil or groundwater pollutants. To be successful, vegetation must transpire enough water from the soil or groundwater to control or take up the contaminant. Transpiration is driven by a combination of abiotic (climate, soil water availability, and groundwater depth) and biotic (leaf area, stomatal functions, root amount and distribution, and hydraulic characteristics) that need to be evaluated when considering appropriate site and species combinations. The protocols are not trivial, but transpiration can be measured at a variety of scales using techniques such as direct measurements of sap flow on individual trees, eddy flux gradient analyses, or gauged watersheds. Alternatively, models can be used to estimate transpiration, but these usually require on-site calibration or parameterization to produce accurate predictions. Case study analyses across a range of site conditions and species indicate a maximum transpiration capacity of approximately 7.5 × 106 liters of water per hectare per year (8 × 105 gallons of water per acre per year), with a range of 1.5 × 106 to 7.5 × 106 liters per hectare per year (1.6 × 105 to 8 × 105 gallons per acre per year). Variation among sites is related to species, tree size, and stocking (i.e., vegetation density) differences. Application of a physiologically based and site-specific parameterized model suggests reasonable agreement between measured and predicted transpiration estimates for the Air Force Plant 4 site in central Texas. Keywords: tree and stand level; transpiration; transpiration; evapotranspiration; leaf conductance; sapwood thickness
Migraine headache is present in the aura phase

ABSTRACT Objectives: Migraine aura is commonly considered to be a distinct phase of a migraine attack that precedes headache. The objective of the study was to examine a large number of prospectively recorded attacks of migraine with aura and determine the timing of headache and other migraine symptoms relative to aura. Methods: As part of a clinical trial we collected prospective data on the time course of headache and other symptoms relative to the aura. Patients (n = 267) were enrolled from 16 centers, and asked to keep a headache diary for 1 month (phase I). They were asked to record headache symptoms as soon as possible after aura began and always within 1 hour of aura onset. A total of 456 attacks were reported during phase I by 201 patients. These patients were then randomized and included in phase II, during which a total of 405 attacks were reported in 164 patients. In total, we present data from 861 attacks of migraine with aura from 201 patients. Results: During the aura phase, the majority of attacks (73%) were associated with headache. Other migraine symptoms were also frequently reported during the aura: nausea (51%), photophobia (88%), and photophobia (73%). During the first 15 minutes within the onset of aura, 54% of patients reported headache fulfilling the criteria for migraine. Conclusion: Our results indicate that headaches as well as associated migraine symptoms are present early, during the aura phase of the migraine attack in the majority of patients.
Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients With Heart Failure With Reduced Ejection Fraction

October 29, 2019 1463 BACKGROUND: Outcome trials in patients with type 2 diabetes mellitus have demonstrated reduced hospitalizations for heart failure (HF) with sodium-glucose co-transporter-2 inhibitors. However, few of these patients had HF, and those that did were not well-characterized. Thus, the effects of sodium-glucose co-transporter-2 inhibitors in patients with established HF with reduced ejection fraction, including those with and without type 2 diabetes mellitus, remain unknown.
Predictive Model for the Water Retention Curve of Deformable Clayey Soils

Tests for determining the water retention curve (WRC) can be time-consuming and tedious, especially with deformable soils for which volume change and water content have to be simultaneously monitored. In some cases, predictive models can become a practical alternative to obtain an estimate of the WRC. However, very few models are available to predict the WRC of deformable materials under increasing suction. In this paper, the modified Kovacs (MK) model, developed initially for incompressible soils, is extended to describe and, in some cases, predict the WRC of deformable clayey soils. This generalization of the MK model is performed by introducing the volumetric shrinkage curve (VSC) in its formulation. A curvilinear equation is proposed to represent the void ratio-suction function e (ψ) corresponding to the VSC. This VSC model and the extended MK model ( MKd ) are validated using experimental data taken from the literature. Empirical relationships are developed for predictive purposes to estimate the par.
Unusually quick development of a 4000 nT substorm during the initial 10 min of the 29 October 2003 magnetic storm

[1] Global geomagnetic field data, IMAGE FUV data, and many other in situ observations are presented for the initial 10 min of the magnetic storm starting 29 October 2003 at around 0610 UT. Within 1 min after sudden commencement (SC), two independent strong westward ionospheric electrojets (>2000 nT) at the inner magnetospheric region started simultaneously, one in the evening-midnight sector and the other in the morning sector. Both activities expanded and accompanied auroral expansion. The locations (inner magnetosphere), morphologies (expansion), and intensities (>2000 nT) of both activities fall into substorm expansive phases. Having such simultaneous independent 2000 nT level expansions makes this event unique. The interplanetary magnetic field condition before the SC was not favorable in causing an AL < −2000 nT activity. A timing analysis indicates that these strong westward electrojets were most likely triggered by the interplanetary shock, with the triggering location not farther than the geosynchronous distance. They are also probably maintained by the direct energy pumping from the solar wind because cross-tail current derived from the closely located GOES-10 and Polar did not decrease very much during this period. A local but even stronger geomagnetic (nearly 4000 nT) and auroral activity started only 6 min after the start of SC at postmidnight where and when the above two expanding activities met each other, although the relation between the onset of 4000 nT activity and the preceding expansions is not clear. The suddenness of this third activity (3000 nT change within 2 min) is another unique feature.
Coastal processes along the Indian coastline

onstrated that the average stress drop is higher for intr aplate eart hquakes compared to inter -plate earthquakes. The stress drop has been estimated by se veral workers for the 1993 Latur (M 6.2), 1997 Jabalpur (M 5.8), 1969 Bhadrachalam (M 5.7), 1970 Broach (M 5.2) and Koyna earthquakes and is found to vary between 2 and 25 MPa (Figure 4). A maximum stress drop of 19 MPa obtained for the 14 March earthquake is comp arable to the results which have been obtained from an ea rlier study 17 . The stress drop for the Koyna–Warna earthquakes (magnitude 1.5–4.7) was estimated to be in the range 0.03 to 19 MPa, with the M 4.7 earthquake having the maximum stress drop of 19 MPa. In general, the Koyna–Warna region is cons picuous with higher stress drop in comparison to other source regions in the Peninsular shield. A probable e xplanation for the high stress drop is due to the presence of competent material within the source volume. Velocity tomography study 18 has revealed the presence of high velocity zone in the Koyna–Warna seismic source region and this high velocity was interpret ed in terms of competent material.
Quantitative morphometric analysis of lakes using GIS: rectangularity R, ellipticity E, orientation O, and the rectangularity vs. ellipticity index, REi

Quantitative measures of polygon shapes and orientation are important elements of geospatial analysis. These kinds of measures are particularly valuable in the case of lakes, where shape and orientation patterns can help identifying the geomorphological agents behind lake formation and evolution. However, the lack of built-in tools in commercial geographic information system (GIS) software packages designed for this kind of analysis has meant that many researchers often must rely on tools and workarounds that are not always accurate. Here, an easy-to-use method to measure rectangularity R, ellipticity E, and orientation O is developed. In addition, a new rectangularity vs. ellipticity index, REi, is defined. Following a step-by-step process, it is shown how these measures and index can be easily calculated using a combination of GIS built-in functions. The identification of shapes and estimation of orientations performed by this method is applied to the case study of the geometric and oriented lakes of the Llanos de Moxos, in the Bolivian Amazon, where shape and orientation have been the two most important elements studied to infer possible formation mechanisms. It is shown that, thanks to these new indexes, shape and orientation patterns are unveiled, which would have been hard to identify otherwise.
SEISMIC HAZARD ASSESSMENT OF UNITED ARAB EMIRATES AND ITS SURROUNDINGS

This paper presents the seismic hazard assessment and seismic zoning of the United Arab Emirates (UAE) and its surroundings based on the probabilistic approach. The area that has been studied lies between 50°E-60°E and 20°N-30°N and spans several Gulf countries. First, the tectonics of the area and its surroundings is reviewed. An updated catalogue, containing both historical and instrumental events is used. Seismic source regions are modelled and relationships between earthquake magnitude and earthquake frequency is established. A modified attenuation relation for Zagros region is adopted. Seismic hazard assessment is then carried out for 20 km interval grid points. Seismic hazard maps of the studied area based on probable Peak Ground Acceleration (PGA) for 10% probability of exceedance for time-spans of 50, 100 and 200 years are shown. A seismic zone map is also shown for a 475-year return period. Although the results of the seismic hazard assessment indicated that UAE has moderate to low seismic hazard levels, nevertheless high seismic activities in the northern part of UAE warrant attention. The northern Emirates region is the most seismically active part of UAE. The PGA on bedrock in this region ranges between 0.22 g for a return period of 475 years to 0.38 g for a return period of 1900 years. This magnitude of PGA, together with amplification from local site effect, can cause structural damage to key structures and lifeline systems.
Cardiovascular Disease in Women with Breast Cancer – A Nationwide Registry Study

Background: There is increasing concern about cardiovascular disease (CVD) after breast cancer (BC). The aim of this study was to estimate the prevalence of different types of CVD in women diagnosed with BC compared to cancer-free controls as well as the incidence of CVD after BC diagnosis.Methods: We performed a cohort study based on data from national registries covering the entire Danish population. We followed 16,505 cancer-naïve BC patients diagnosed from 2003 to 2007 five years before and up to 10 years after BC diagnosis compared to 165,042 cancer-free controls. Results: We found that 15.6% of BC patients were registered with at least one CVD diagnosis in hospital records before BC diagnosis. Overall, BC patients and controls were similar with regards to CVD comorbidity before BC diagnosis. After BC diagnosis, the incidence of all CVD diagnoses combined was significantly higher in BC patients than controls up to approximately 6 years after the index date (BC diagnosis). The incidence of heart failure, thrombophlebitis/thrombosis and pulmonary heart disease including pulmonary embolism remained higher in BC patients than controls during the entire 10 year follow-up period. Furthermore, we found that the risk of heart failure and thrombophlebitis/thrombosis was higher after chemotherapy. Conclusions: Focus on CVD in BC patients is important to ensure optimum treatment with regards to BC as well as possible CVD. Strategies to minimise and manage the increased risk of heart failure, thrombophlebitis/thrombosis and pulmonary heart disease including pulmonary embolism in BC patients are especially important.
Prevalence of bullying and associated factors among Brazilian schoolchildren in 2015

This study analyzed the prevalence of bullying and associated factors among Brazilian schoolchildren using data produced by the 2015 National School Health Survey (PeNSE, acronym in Portuguese) consisting of a national sample of 102,301 eighth grade students. The prevalence of bullying was calculated and bivariate analysis was performed using a 95% confidence level to determine the association between victimization and socio-demographic variables and other variables relating to family background, mental health, and risk behaviors. Multivariate analysis was then conducted using the biologically plausible variables of interest. For the final model, variables that obtained p-values of < 0.05 were maintained. The prevalence of bullying was found to be 7.4%. The results of the multivariate analysis showed that boys aged 13 years studying in public schools who worked and whose mother did not have any schooling were more likely to be bullied, as were schoolchildren who felt lonely, had no friends, suffered from insomnia, skipped lessons without parental permission, and who smoked. Victims of bullying were predominantly 13-year-olds from an unfavorable social and family background, painting a picture of vulnerability that calls for support from social protection networks, schools and families alike.