Miracle-dz/UniFAR-FTUs huggingface dataset:
Bite-Weight Estimation Using Commercial Ear Buds

While automatic tracking and measuring of our physical activity is a well established domain, not only in research but also in commercial products and every-day lifestyle, automatic measurement of eating behavior is significantly more limited. Despite the abundance of methods and algorithms that are available in bibliography, commercial solutions are mostly limited to digital logging applications for smart-phones. One factor that limits the adoption of such solutions is that they usually require specialized hardware or sensors. Based on this, we evaluate the potential for estimating the weight of consumed food (per bite) based only on the audio signal that is captured by commercial ear buds (Samsung Galaxy Buds). Specifically, we examine a combination of features (both audio and non-audio features) and trainable estimators (linear regression, support vector regression, and neural-network based estimators) and evaluate on an in-house dataset of 8 participants and 4 food types. Results indicate good potential for this approach: our best results yield mean absolute error of less than 1 g for 3 out of 4 food types when training food-specific models, and 2.1 g when training on all food types together, both of which improve over an existing literature approach.
Nanocarriers for transdermal drug delivery

1Sistemas Transdermicos y Materiales Nanoestructurados, 2Toxicologia y Genetica, Universidad Nacional Autonoma de Mexico, Cuautitlan Izcalli, Mexico; 3Unidad de Ensenanza e Investigacion, Hospital Regional de Alta Especialidad de Zumpango, Zumpango, Mexico; 4Departamento de Ingenieria y Tecnologia, 5Departamento de Ciencias Quimicas, 6Laboratorio de Quimica Medicinal, Universidad Nacional Autonoma de Mexico, Cuautitlan Izcalli, Mexico; 7Departamento de Sistemas Biologicos, Universidad Autonoma Metropolitana-Xochimilco, Mexico City, Mexico
Dense-Res Net for Endoscopic Image Classification

We propose a method that configures Fine-tuning to a combination of backbone DenseNet and ResNet to classify eight classes showing anatomical landmarks, pathological findings, to endoscopic procedures in the GI tract. Our Technique depends on Transfer Learning which combines two backbones, DenseNet 121 and ResNet 101, to improve the performance of Feature Extraction for classifying the target class. After experiment and evaluating our work, we get accuracy with an F1 score of approximately 0.93 while training 80000 and test 4000 images.
SEQUENTIAL PROCEDURES IN SIMULATION STUDIES OF SA TEUJTE COMMUNICA nON PROTOCOLS

In this paper we discuss two sequential procedures developed for analysis of simulation output data in performance evaluation of satellite communication protocols. The proce dures automatically control the length of the simulation run until the required accuracy of results is achieved. Because the experiments revealed relatively short initial transient periods in simulated processes, each procedure tries additionally to determine the actu allength of the warm-up periods, to discard possibly small number of initial output data that do not represent steady state. Numerical results are presented to compare the quality of the procedures.
Patient satisfaction with calcipotriol/betamethasone dipropionate cutaneous foam for the treatment of plaque psoriasis: The LION real‐life multicenter prospective observational cohort study

Topical treatment is the mainstay for mild or moderate psoriasis, but patients are generally little satisfied. Calcipotriol/betamethasone dipropionate (Cal/BD) cutaneous foam has shown to improve signs and symptoms in plaque psoriasis patients. This study assessed patient's satisfaction with Cal/BD foam in a real‐life Italian dermatological clinical practice. A multicenter, 4‐week observational prospective cohort study enrolled, in 17 Italian dermatology clinics, adult patients with plaque psoriasis on the body and/or scalp. Treatment satisfaction was assessed by 9‐item Treatment Satisfaction Questionnaire for Medication (TSQM‐9), preference over previous treatments by Patient Preference Questionnaire (PPQ), and change in disease state by Psoriasis Area Severity Index (PASI). Overall 256 patients were eligible, with a mean (SD) age of 55.6 (15.4) years, 59.4% were males. Psoriasis severity was mild in 52.0% of patients, moderate in 43.3%, and severe in 4.7%. Scalp involvement was present in 36.7% of patients. Previous antipsoriatic treatments had been received by 80.5% of patients. TSQM‐9 median (25th–75th percentile) scores were 83.3 (66.7–88.9) for effectiveness, 77.8 (66.7–88.9) for convenience, and 78.6 (64.3–92.9) for global satisfaction. Mean (SD) PASI value decreased from 7.3 (4.8) to 2.1 (2.7) after 4 weeks. More than 90% of patients previously treated for psoriasis evaluated the Cal/BD foam more effective, easier to use and better tolerated compared to previous topical treatments at PPQ. This observational study provides real‐life evidence of a high level of satisfaction with effectiveness and convenience of the Cal/BD foam in a cohort of plaque psoriasis patients, with an objective improvement in PASI.
Real-world data for golimumab treatment in patients with ulcerative colitis in Japan: interim analysis in post-marketing surveillance

Background/Aims Golimumab (GLM) is an anti-tumor necrosis factor-α drug approved for treating moderate-to-severe active ulcerative colitis (UC). A 52-week post-marketing surveillance (PMS) was initiated to evaluate its safety and effectiveness in patients with UC in Japan. We present an interim report of the ongoing PMS. Methods Patients received 200 mg of subcutaneous GLM at week 0, 100 mg at week 2, and 100 mg 4 weekly thereafter. The safety analysis set included 392 patients with UC, and the effectiveness analysis set 387 patients. Safety and effectiveness were assessed at week 6. Results Adverse drug reactions (ADRs) were reported in 8.2% (32/392) and serious ADRs in 4.6% (18/392). The most frequent ADRs were infection and infestation (3.3%), with herpes zoster being the most common. ADRs were significantly higher in patients with concomitant corticosteroid use (odds ratio [OR], 3.45; 95% confidence interval [CI], 1.40–9.68). No significant difference in ADR incidence was observed between patients aged ≥65 and <65 years (OR, 1.23; 95% CI, 0.35–3.47). Six-week effectiveness of GLM was confirmed by a decrease in the partial Mayo score (–2.3; 95% CI, –2.6 to –2.1) and C-reactive protein levels (–0.64; 95% CI, –0.92 to –0.36), including in the biologics-experienced population. Conclusions The safety and effectiveness of GLM at week 6 in a real-world setting were demonstrated in patients with UC in Japan. ADR patterns were consistent with previous reports with no new safety signals. Concomitant corticosteroid use may be associated with increased ADR incidence. The final results of the ongoing PMS are necessary for further evaluation.
The Emotional Effects of Gain-Loss Frames in Persuasive Messages about Sun Protection on Health Promotional Outcomes: Evidence from an Experimental Study

ABSTRACT Although the importance of emotions for the effects of gain-loss framed messages has been supported, the emotional effects of mixed frames have not been sufficiently investigated. To fill this gap, this experimental study exposed participants (N = 154) to single gain- or loss-framed vs. mixed frame messages about sun-protection outcomes. Integrating the idea of mixed frames with the concept of emotional flow, data were analyzed using a serial mediation model with emotional experience (as indexed by valence and arousal) and intention as factors mediating the effect of shifts on actual behavior, measured two weeks after message exposure. Results demonstrate that mixed messages and their impact on emotional experiences are not generally more effective than pure gain or pure loss messages. However, the application of mixed frame or purely loss-framed messages offers a higher potential to increase behavioral health intentions (resulting in respective behaviors) than messages simply focusing on gain frames.
Revised alkenone δ13C based CO2 estimates during the Plio-Pleistocene

Here we revisit reported alkenone d13C (d13CC37) based CO2 records during the Plio-Pleistocene and apply a refined approach to better constrain the dynamic range of CO2 during the time. Specifically, we consider ways to correct for regional differences in physical oceanographic factors. As a result of our relatively simple approach we find that offsets of ~150 ppm between reported d13CC37 CO2 records from different sites can be significantly reduced. This confirms that better constraints 10 on environmental variables, including physical oceanographic controls on depth and season of production are key aspects for improving d13CC37 based CO2 estimates. The revised d13CC37 CO2 datasets suggest that Plio-Pleistocene CO2 levels are 180350 ppm, which is consistent with the most of reported CO2 reconstructions, though their upper end of Pliocene CO2 levels are lower than that of some CO2 estimates.
Antioxidant potentialities and Antiradical Activities of Oxalis corniculata Linn from Tanzania.

Introduction : This study provides essential antioxidant potentialities of the plant Oxalis corniculata Linn (creeping wood sorrell) indigenous from Tanzania and the associated precursors of biochemical compounds responsible for its folkloric pharmacological rationales. Methodology and Results : Extracts were made from the whole plant using methanol and ethanol solvents. DPPH assay was used to evaluate its antioxidant potentials while phytochemical screening for precursors of biochemical compounds responsible for its pharmacological rationales was qualitatively determined. Total antioxidant necessary to decrease the initial DPPH radical concentration by 50% (EC 50 ) value, were obtained from the linear regression plots of Sigma Plot R (2001). Results showed significant activities in all antioxidant assays compared to the reference antioxidant ascorbic acid in a dose dependent manner. In DPPH scavenging assay the EC 50 value of the crude extract was found to be 0.04 mg/ml while that of the reference standard ascorbic acid was 0.59 mg/ml. Likewise the highest iron chelating ability of 97.31% was obtained at a higher crude extract concentration of 0.4 mM while the lowest ability of 23.25% was obtained at the lowest crude extract concentration of 0.001mM. It also portrayed high antiradical activities of up to EAU515 = 1.868 number of antiradical unit and several precursors of biochemical compounds including Flavonoids, Terpenoids, Coumarins, Glycosides, as well as Steroids and Phytosteroids. Conclusion and application of results: The results indicated that Oxalis corniculata could be an important dietary source of antioxidants with high scavenging abilities as well as rich in biomolecules that are precursors of most biologically active chemicals of medical importance. These findings may thus, justify their wide usage in traditional medicine and envisage a purposeful thoroughly study for possible developments into nutraceutical and drugs. Key words : antioxidants, antiradical, folk medicine, Oxalis corniculata , DPPH
Identification of an eleven-miRNA signature to predict the prognosis of endometrial cancer

ABSTRACT Endometrial cancer (EC) is the most common gynecological malignancy. Recent studies have uncovered miRNA acted a striking role in predicting the prognosis of multiple tumors. Over 500 EC samples were selected from the Cancer Genome Atlas (TCGA) database. Univariate, LASSO and multivariate Cox regression analysis were employed to screen out the prognosis-involved miRNAs. Kaplan-Meier (K-M) and time-dependent receiver operation characteristic (ROC) curves were conducted to reveal survival analysis and assess the accuracy of the signature. The independence of the model was verified via univariate and multivariate Cox regression analysis. Besides, qRT-PCR was conducted to testified the expression of 11 miRNAs in 16 paired tissues. A total of 514 specimens were randomly divided into the training set and the testing set, then an 11 miRNAs-based signature were determined which divided the patients into high-risk group and low-risk group. The survival was markedly different and the ROC curve exhibited a precise prediction. Meanwhile, the univariate and multivariate Cox regression analysis verified the miRNAs-based model was an independent indicator of EC. Moreove, the prediction ability of this model with clinicopathological features was more efficient. Finally, functional enrichment analysis demonstrated these miRNAs were associated with the occurrence and progression of cancer. Additionally, hsa-mir-216b, hsa-mir-363, hsa-mir-940 and hsa-mir-1301 were highly expressed in EC tissues in contrast to normal tissues through qRT-PCR. Importantly, the eleven-miRNA signature was full of robust ability to predict the prognosis of EC. GRAPHICAL ABSTRACT
Surgical interventions for symptomatic urinary stones during pregnancy

Here we describe the experience in China employing surgical interventions for symptomatic urinary stones during pregnancy. Thirty-five records of pregnant women with symptomatic urinary calculi who failed initial conservative measures and underwent active treatment in our hospital between April 2017 and May 2019 were retrospectively reviewed (Supplementary Table 1, http:// links.lww.com/CM9/A671 and Supplementary Figure 1, http://links.lww.com/CM9/A670).
Orbital Growth is Associated with Eyeball Size: A Study Using CT-based Three-dimensional Techniques

ABSTRACT Aim of the study This study was aimed to investigate the growth patterns and the relationship of the eyeball and the orbit using computed tomography (CT)-based three-dimensional (3D) techniques. Materials and Methods A total of 175 Chinese patients who had undergone craniofacial or orbital CT scans were enrolled. This study only included data from the unaffected eye and orbit. Images were processed using 3D reconstruction to obtain the eyeball and the orbit parameters. Results In early postnatal years, the sizes of eyeball and orbit increased significantly with age (p < 0.001) and reached a turning point at a critical age (8.967 and 12.800 years for the eyeball and orbit volume, respectively). The orbital index and orbital depth index, showing the shape of the orbital aperture and walls, decreased significantly with age (p < 0.001). In all ages, the orbit size was correlated with eyeball size (p < 0.001). The eye-orbit index, equivalent to the ratio of eye volume to orbital volume, declined steadily with age (p < 0.001). Conclusions The eyeball and orbit developed rapidly in early postnatal years, and then matured at a critical age. The eyeball size significantly contributed to the orbital growth; this contribution may be reduced as the eye-orbit index decreased with age. To the best of our knowledge, this is the first report on the growth and interrelation of the eyeball and the orbit using CT-based 3D techniques.
Breathlessness and COVID-19: A Call for Research

Breathlessness, also known as dyspnoea, is a debilitating and frequent symptom. Several reports have highlighted the lack of dyspnoea in a subgroup of patients suffering from COVID-19, sometimes referred to as “silent” or “happy hypoxaemia. ” Reports have also mentioned the absence of a clear relationship between the clinical severity of the disease and levels of breathlessness reported by patients. The cerebral complications of COVID-19 have been largely demonstrated with a high prevalence of an acute encephalopathy that could possibly affect the processing of afferent signals or top-down modulation of breathlessness signals. In this review, we aim to highlight the mechanisms involved in breathlessness and summarize the pathophysiology of COVID-19 and its known effects on the brain-lung interaction. We then offer hypotheses for the alteration of breathlessness perception in COVID-19 patients and suggest ways of further researching this phenomenon.
Real-time navigation guidance with intraoperative CT imaging for pedicle screw placement using an augmented reality head-mounted display: a proof-of-concept study.

OBJECTIVE Augmented reality (AR) has the potential to improve the accuracy and efficiency of instrumentation placement in spinal fusion surgery, increasing patient safety and outcomes, optimizing ergonomics in the surgical suite, and ultimately lowering procedural costs. The authors sought to describe the use of a commercial prototype Spine AR platform (SpineAR) that provides a commercial AR head-mounted display (ARHMD) user interface for navigation-guided spine surgery incorporating real-time navigation images from intraoperative imaging with a 3D-reconstructed model in the surgeon's field of view, and to assess screw placement accuracy via this method. METHODS Pedicle screw placement accuracy was assessed and compared with literature-reported data of the freehand (FH) technique. Accuracy with SpineAR was also compared between participants of varying spine surgical experience. Eleven operators without prior experience with AR-assisted pedicle screw placement took part in the study: 5 attending neurosurgeons and 6 trainees (1 neurosurgical fellow, 1 senior orthopedic resident, 3 neurosurgical residents, and 1 medical student). Commercially available 3D-printed lumbar spine models were utilized as surrogates of human anatomy. Among the operators, a total of 192 screws were instrumented bilaterally from L2-5 using SpineAR in 24 lumbar spine models. All but one trainee also inserted 8 screws using the FH method. In addition to accuracy scoring using the Gertzbein-Robbins grading scale, axial trajectory was assessed, and user feedback on experience with SpineAR was collected. RESULTS Based on the Gertzbein-Robbins grading scale, the overall screw placement accuracy using SpineAR among all users was 98.4% (192 screws). Accuracy for attendings and trainees was 99.1% (112 screws) and 97.5% (80 screws), respectively. Accuracy rates were higher compared with literature-reported lumbar screw placement accuracy using FH for attendings (99.1% vs 94.32%; p = 0.0212) and all users (98.4% vs 94.32%; p = 0.0099). The percentage of total inserted screws with a minimum of 5° medial angulation was 100%. No differences were observed between attendings and trainees or between the two methods. User feedback on SpineAR was generally positive. CONCLUSIONS Screw placement was feasible and accurate using SpineAR, an ARHMD platform with real-time navigation guidance that provided a favorable surgeon-user experience.
Systematic Review and Meta-analysis of Histological Gastric Biopsy Aspects According to the Updated Sydney System in Children

Supplemental Digital Content is available in the text ABSTRACT Objectives: A descriptive and comparative study of gastric histological aspects according to the updated Sydney classification (USC), obtained from Helicobacter pylori-positive versus H pylori-negative children referred for upper gastrointestinal endoscopy. Methods: The Prisma method was used to perform a systematic review and meta-analysis. Selection criteria were based on following key words USC, H pylori, children, endoscopy, or biopsy. Publication biases were assessed according to the Newcastle-Ottawa Scale, and a meta-regression analysis was done. The study was registered on the PROSPERO platform. Results: Between 1994 and 2017, 1238 references were found; 97 studies were retained for the systematic review with a total number of 25,867 children; 75 studies were selected for the meta-analysis concerning 5990 H pylori-infected and 17,782 uninfected children. H pylori-positive versus H pylori-negative children, according to the USC, showed significantly higher relative risk for gastric antral and corpus chronic inflammation, presence of neutrophils, and of lymphoid follicles, and gastric mucosa atrophy, whereas, intestinal metaplasia showed a significantly higher RR only in antral biopsies. The meta-regression analysis showed that H pylori-positive versus H pylori-negative children had significantly higher risk only for corpus activity according to age, recurrent abdominal pain, and geographical area of low H pylori prevalence. Conclusions: H pylori infection in children was associated with higher relative risk for gastric antral and corpus chronic inflammation, presence of neutrophils, lymphoid follicles, and rare gastric mucosa atrophy, whereas, rare intestinal metaplasia was only significantly higher in the antral area.
Prevalence of Microscopic Colitis in Diarrhea-predominant Irittable Bowel Syndrome Patients

Background and Aim: There is controversy about colonoscopy and taking biopsy from the normal colonic mucosa in patients with a clinical diagnosis of diarrhea-predominant irritable bowel syndrome (D-IBS). This study aims to estimate the prevalence of microscopic colitis (MC) in D-IBS patients and to select patients without the well-known alarming features who will benefit from colonoscopy and biopsies from the normal colonic mucosa. Patients and Methods: We performed a cohort cross-sectional study over 6 months duration in a total of 129 patients with Rome III criteria of D-IBS after excluding cases with features of organic diseases. Cases were subjected to colonoscopy and biopsies from the colonic mucosa that seemed normal. Results: Histopathologic examination of biopsies taken from cases with normal colonic mucosa revealed 86 (71.66%) cases with nonspecific colitis, 26 (21.66%) cases with MC and 8 (6.66%) cases with ulcerative colitis. Concomitant immunologic diseases (P=0.00005) and triggering drugs intake (P=0.006) were significantly more common in the MC group. The mean duration of diarrhea in MC patients was significantly longer than that of nonspecific colitis and ulcerative colitis patients (P=0.0006). Conclusions: Prevalence of MC in D-IBS patients from Upper Egypt is relatively high (21.66%). Concomitant immunologic diseases, possible triggering drugs intake, and long duration of diarrhea are significant risk factors for undiagnosed MC in D-IBS patients.
Measurement of Activity Coefficients at Infinite Dilution for Alcohols in [BMIM][CH3SO4] using HS-SPME/GC-FID

The activity coefficient at infinite dilution( i γ ∞ )and distribution ratios at infinite dilution ( i K ∞ ) were determined for alkanols (methanol, ethanol, 1-propanol, 1-butanol, 2-butanol, and 2-methyl-2-propanol) in the ionic liquid (IL) 1-butyl-3-methylimidazolium methyl sulfate ([BMIM][CH3SO4]) by HS-SPME (Headspace Solid Phase Micro Extraction) at four temperatures (298.15, 313.15, 333.15, and 353.15K) using headspace solid phase microextraction (SPME-HS). The results showed significant agreement with literature data. In addition, partial molar excess enthalpies at infinite dilution ( ) , E i H ∞ ∆ , excess Gibbs energies ( ) , E i G ∞ ∆ , and excess entropies ( ) , E i S ∞ ∆ were calculated from the i γ ∞ values.
OP-NDTJ200320 1..2

Sébastien Rubin , Romain Boulestreau, Philippe Gosse and Christian Combe 1,5 Néphrologie, Transplantation, Dialyse et Aphérèse, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France, Unité INSERM U1034, Univ. Bordeaux, Bordeaux, France, Cardiologie, Centre Hospitalier de Pau, Pau, France, Cardiologie et Hypertension artérielle, European Hypertension Excellence Centre, Hôpital Saint André, CHU de Bordeaux, Bordeaux, France and Unité INSERM Biotis U1026, Univ. Bordeaux, Bordeaux, France