Miracle-dz/UniFAR-FTUs huggingface dataset:
Alkali Soil Reclamation with Flue Gas Desulfurization Gypsum in China and Assessment of Metal Content in Corn Grains

Flue gas desulfurization gypsum (FGDG), the by-product of wet and semi-dry desulfurization processes, has been used as an alkali soil amendment in China. We evaluated the change in soil properties, agricultural production and the safety of FGDG as a soil amendment. As a result, soil pH and ESP (exchangeable sodium percentage) decreased and corn production increased in FGDG-treated plots. The metal (B, Cr, Mn, Ni, Cu, As, Cd, Pb) contents in soil, FGDG, and corn grains were quantified by ICP-MS. Consequently, the contents of almost all metals in FGDG were lower than in soil. Moreover, the contents of almost all of the metals in the corn grains in the FGDG-treated plots were almost the same or lower than those in the control plot. Statistical analysis indicated that there was no effect of gypsum application on the metal content in the corn grains. Almost all of the metal contents were lower than the standard values set by FAO/WHO for human intake. The results showed that the FGDG from wet and semi-dry FGD processes is suitable as an alkali soil amendment.
Rates of COVID-19 Among Residents and Staff Members in Nursing Homes — United States, May 25–November 22, 2020

During the beginning of the coronavirus disease 2019 (COVID-19) pandemic, nursing homes were identified as congregate settings at high risk for outbreaks of COVID-19 (1,2). Their residents also are at higher risk than the general population for morbidity and mortality associated with infection with SARS-CoV-2, the virus that causes COVID-19, in light of the association of severe outcomes with older age and certain underlying medical conditions (1,3). CDC's National Healthcare Safety Network (NHSN) launched nationwide, facility-level COVID-19 nursing home surveillance on April 26, 2020. A federal mandate issued by the Centers for Medicare & Medicaid Services (CMS), required nursing homes to commence enrollment and routine reporting of COVID-19 cases among residents and staff members by May 25, 2020. This report uses the NHSN nursing home COVID-19 data reported during May 25-November 22, 2020, to describe COVID-19 rates among nursing home residents and staff members and compares these with rates in surrounding communities by corresponding U.S. Department of Health and Human Services (HHS) region. * COVID-19 cases among nursing home residents increased during June and July 2020, reaching 11.5 cases per 1,000 resident-weeks (calculated as the total number of occupied beds on the day that weekly data were reported) (week of July 26). By mid-September, rates had declined to 6.3 per 1,000 resident-weeks (week of September 13) before increasing again, reaching 23.2 cases per 1,000 resident-weeks by late November (week of November 22). COVID-19 cases among nursing home staff members also increased during June and July (week of July 26 = 10.9 cases per 1,000 resident-weeks) before declining during August-September (week of September 13 = 6.3 per 1,000 resident-weeks); rates increased by late November (week of November 22 = 21.3 cases per 1,000 resident-weeks). Rates of COVID-19 in the surrounding communities followed similar trends. Increases in community rates might be associated with increases in nursing home COVID-19 incidence, and nursing home mitigation strategies need to include a comprehensive plan to monitor local SARS-CoV-2 transmission and minimize high-risk exposures within facilities.
Influences of Anabolic Hormone Treatment and Dietary Protein: Energy Ratio on Condition and Muscle Deposition of Rainbow Trout

Abstract The effects of dietary 17a-methyltestosterone (MT) and protein-to-metabolizable energy (P:ME) ratios on the weight gain of individual body components and their relative contribution to the condition factor (K) were examined for juvenile rainbow trout (Salmo gairdneri). Five semipurified isocaloric diets (390 kcal/100 g dry ingredients) containing 80, 100, 120, 140, and 160 mg protein/kcal ME were prepared with and without 2.0 mg MT/kg of diet and fed to 5-g rainbow trout for 8 weeks. At the end of the experiment, fish were weighed and measured, and then dissected or cooked to obtain individual wet weights of the head, fins, skin, muscle, carcass bone, viscera, and rib section. Steroid treatment increased the weight gain of muscle tissue in direct proportion to the increase in body weight gain. Linear bone growth was enhanced with treatment, but the rate of increase did not keep pace with the rate of weight increase of the rest of the body. This accounted for a lowered percentage bone weight gain .
Nitrospira as versatile nitrifiers: Taxonomy, ecophysiology, genome characteristics, growth, and metabolic diversity

The global nitrogen cycle is of paramount significance as it affects important processes like primary productivity and decomposition. Nitrification, the oxidation of ammonia to nitrate via nitrite, is a key process in the nitrogen cycle. The knowledge about nitrification has been challenged during the last few decades with inventions like anaerobic ammonia oxidation, ammonia‐oxidizing archaea, and recently the complete ammonia oxidation (comammox). The discovery of comammox Nitrospira has made a paradigm shift in nitrification, before which it was considered as a two‐step process, mediated by chemolithoautotrophic ammonia oxidizers and nitrite oxidizers. The genome of comammox Nitrospira equipped with molecular machineries for both ammonia and nitrite oxidation. The genus Nitrospira is ubiquitous, comes under phylum Nitrospirae, which comprises six sublineages consisting of canonical nitrite oxidizers and comammox. The single‐step nitrification is energetically more feasible; furthermore, the existence of diverse metabolic pathways in Nitrospira is critical for its establishment in various habitats. The present review discusses the taxonomy, ecophysiology, isolation, identification, growth, and metabolic diversity of the genus Nitrospira; compares the genomes of canonical nitrite‐oxidizing Nitrospira and comammox Nitrospira, and analyses the differences of Nitrospira with other nitrifying bacteria.
Construction of co‐expression modules related to survival by WGCNA and identification of potential prognostic biomarkers in glioblastoma

Glioblastoma (GBM) is a malignant brain tumour with poor prognosis. The potential pathogenesis and therapeutic target are still need to be explored. Herein, TCGA expression profile data and clinical information were downloaded, and the WGCNA was conducted. Hub genes which closely related to poor prognosis of GBM were obtained. Further, the relationship between the genes of interest and prognosis of GBM, and immune microenvironment were analysed. Patients from TCGA were divided into high‐ and low‐risk group. WGCNA was applied to the high‐ and low‐risk group and the black module with the lowest preservation was identified which could distinguish the prognosis level of these two groups. The top 10 hub genes which were closely related to poor prognosis of patients were obtained. GO analysis showed the biological process of these genes mainly enriched in: Cell cycle, Progesterone‐mediated oocyte maturation and Oocyte meiosis. CDCA5 and CDCA8 were screened out as the genes of interest. We found that their expression levels were closely related to overall survival. The difference analysis resulted from the TCGA database proved both CDCA5 and CDCA8 were highly expressed in GBM. After transfection of U87‐MG cells with small interfering RNA, it revealed that knockdown of the CDCA5 and CDCA8 could influence the biological behaviours of proliferation, clonogenicity and apoptosis of GBM cells. Then, single‐gene analysis was performed. CDCA5 and CDCA8 both had good correlations with genes that regulate cell cycle in the p53 signalling pathway. Moreover, it revealed that high amplification of CDCA5 was correlated with CD8+ T cells while CDCA8 with CD4+ T cells in GBM. These results might provide new molecular targets and intervention strategy for GBM.
Effects of Behavioral Risk Factors and Social-Environmental Factors on Non-Communicable Diseases in South Korea: A National Survey Approach

Non-communicable diseases (NCDs) are one of the major health threats in the world. Thus, identifying the factors that influence NCDs is crucial to monitor and manage diseases. This study investigates the effects of social-environmental and behavioral risk factors on NCDs as well as the effects of social-environmental factors on behavioral risk factors using an integrated research model. This study used a dataset from the 2017 Korea National Health and Nutrition Examination Survey. After filtering incomplete responses, 5462 valid responses remained. Items including one’s social-environmental factors (household income, education level, and region), behavioral factors (alcohol use, tobacco use, and physical activity), and NCDs histories were used for analyses. To develop a comprehensive index of each factor that allows comparison between different concepts, the researchers assigned scores to indicators of the factors and calculated a ratio of the scores. A series of path analyses were conducted to determine the extent of relationships among NCDs and risk factors. The results showed that social-environmental factors have notable effects on stroke, myocardial infarction, angina, diabetes, and gastric, liver, colon, lung, and thyroid cancers. The results indicate that the effects of social-environmental and behavioral risk factors on NCDs vary across the different types of diseases. The effects of social-environmental factors and behavioral risk factors significantly affected NCDs. However, the effect of social-environmental factors on behavioral risk factors was not supported. Furthermore, social-environmental factors and behavioral risk factors affect NCDs in a similar way. However, the effects of behavioral risk factors were smaller than those of social-environmental factors. The current research suggests taking a comprehensive view of risk factors to further understand the antecedents of NCDs in South Korea.
Targeted temperature management and early neuro-prognostication after cardiac arrest

Targeted temperature management (TTM) is a recommended neuroprotective intervention for coma after out-of-hospital cardiac arrest (OHCA). However, controversies exist concerning the proper implementation and overall efficacy of post-CA TTM, particularly related to optimal timing and depth of TTM and cooling methods. A review of the literature finds that optimizing and individualizing TTM remains an open question requiring further clinical investigation. This paper will summarize the preclinical and clinical trial data to-date, current recommendations, and future directions of this therapy, including new cooling methods under investigation. For now, early induction, maintenance for at least 24 hours, and slow rewarming utilizing endovascular methods may be preferred. Moreover, timely and accurate neuro-prognostication is valuable for guiding ethical and cost-effective management of post-CA coma. Current evidence for early neuro-prognostication after TTM suggests that a combination of initial prediction models, biomarkers, neuroimaging, and electrophysiological methods is the optimal strategy in predicting neurological functional outcomes.
The Impact of Interferon-γ (IFN-γ) and IFN-γ-Inducible Protein 10 (IP-10) Genes’ Polymorphism on Risk of Hepatitis C Virus–Related Liver Cirrhosis

ABSTRACT Background Today there is increasing evidence concerning the association between individual genetic polymorphisms within proinflammatory cytokines and chronic hepatitis C (CHC) severity. It has been demonstrated that polymorphisms in some genes may significantly predict HCV infected patients’ susceptibility to developing liver cirrhosis or their responsiveness to the treatment. Aim We investigated the influence of single nucleotide polymorphisms (SNPs) in Interferon (IFN-γ) and Interferon Gamma-Inducible Protein 10 (IP-10) genes on cirrhosis risk in HCV-infected patients and their association with response to various direct-acting antiviral drugs (DAAs). Methods IFN-γ (+874T/A, +2109A/G) and IP-10 (−135G/A, −1447A/G) genotypes were determined in 175 CHC Egyptian HCV patients (69 liver cirrhotic and 106 non-cirrhotic patients) using either single-stranded polymorphism polymerase chain reaction (SSP-PCR) or Restriction fragment length-PCR (RFLP-PCR) methods. Results IFN-γ + 874 TA, IP-10 − 135AA, and IP-10 − 1447AA and IP-10 − 1447GG genotypes are increased in patients developing liver cirrhosis compared to non-cirrhotic ones. Although, no statistical significance in their distribution was demonstrated, indicating the lack of association between these SNPs and liver cirrhosis susceptibility in HCV-infected patients. Haplotypes analysis between different loci on all selected genes showed a significant increase in AGGA and TAGA and a significant decrease in TGGA haplotypes in cirrhotic patients. Genotype frequencies at loci −135 and −1447 of IP-10 appeared to be in complete Linkage disequilibrium (LD) (D’ = 0.999, r2 = 0.689). Conclusion Our data support the concept that IFN-γ and IP-10 gene polymorphisms are not predictors of disease progression among Egyptian patients with HCV infection.
An investigation into the relationship between stimulus property, neural response and its manifestation in the visual evoked potential involving retinal resolution

The visual evoked potential (VEP) has been shown to reflect the size of the neural population activated by a processing mechanism selective to the temporal – and spatial luminance contrast property of a stimulus. We set out to better understand how the factors determining the neural response associated with these mechanisms. To do so we recorded the VEP from 14 healthy volunteers viewing two series of pattern reversing stimuli with identical temporal—and spatial luminance contrast properties. In one series the size of the elements increased towards the edge of the image, in the other it decreased. In the former element size was congruent with receptive field size across eccentricity, in the later it was incongruent. P100 amplitude to the incongruent series exceeded that obtained to the congruent series. Using electric dipoles due the excitatory neural response we accounted for this using dipole cancellation of electric dipoles of opposite polarity originating in supra‐ and infragranular layers of V1. The phasic neural response in granular lamina of V1 exhibited magnocellular characteristics, the neural response outside of the granular lamina exhibited parvocellular characteristics and was modulated by re‐entrant projections. Using electric current density, we identified areas of the dorsal followed by areas of the ventral stream as the source of the re‐entrant signal modulating infragranular activity. Our work demonstrates that the VEP does not signal reflect the overall level of a neural response but is the result of an interaction between electric dipoles originating from neural responses in different lamina of V1.
Association of Cognitive Function Trajectories in Centenarians With Postmortem Neuropathology, Physical Health, and Other Risk Factors for Cognitive Decline

Key Points Question Are cognitively healthy centenarians resilient against further cognitive decline? Findings In this cohort study of 330 self-reported cognitively healthy centenarians, cognitive trajectories revealed only a slight decline in memory functioning, while other domains remained stable over time. Centenarians maintained high levels of cognitive performance despite being exposed to varying levels of risk factors of cognitive decline, including postmortem Alzheimer disease–associated neuropathologies. Meaning These findings indicate that prolonged maintenance of cognitive functioning may be supported by mechanisms underlying resilience against risk factors of cognitive decline.
Transcultural Adaptation and Theoretical Models of Validation of the Spanish Version of the Self-Care of Heart Failure Index Version 6.2 (SCHFI v.6.2)

Background: Heart failure (HF) is a major and growing public health problem worldwide. Across the world, heart failure is associated with high mortality, high hospitalization rates, and poor quality of life. Self-care is defined as a naturalistic decision-making process involving the choice of behaviors that maintain physiologic stability, the response to symptoms when they occur, and the ability to follow the treatment regimen and control symptoms. One instrument used to measure self-care is the Self Care of Heart Failure Index. Aim: The purpose of this study was to test the psychometric properties of the Spanish version of the Self Care of Heart Failure Index v.6. 2 (SCHFI v.6.2). Methodology: Before testing its psychometric properties, the SCHFI v.6. 2 was translated and adapted from its original English version into Spanish. Subsequently, we tested the instrument’s psychometric properties on a sample of 203 participants with HF. Descriptive statistics were used to analyze the sociodemographic and clinical variables, and to describe item responses. We tested the factorial validity of the SCHFI v.6. 2 using confirmatory and exploratory factor analysis. Results: Confirmatory factor analysis (CFA) was performed using the our pre-existing models which resulted with poor fit indices. Thus, we performed exploratory factor analysis (EFA) on each of the SCHFI v.6. 2 scales. Conclusion: The Spanish version of the SCHFI v.6. 2. has good characteristics of factorial validity and can be used in clinical practice and research to measure self-care in patients with HF.
Comparing Survival of Israeli Acute Paralysis Virus Infection among Stocks of U.S. Honey Bees

Simple Summary Honey bees and other pollinators are threatened by numerous stressors, including virus infections. Currently, no effective treatments are available, stressing the importance of natural defenses. These defenses may be enhanced through selective breeding. This study sought to evaluate the potential for breeding, while also testing a few potential mechanisms of natural immune responses and assessing how widespread viruses are in commercial honey bee queens in the U.S. We identified significant differences in survival of virus infection among and within U.S honey bee stocks, indicating that selective breeding may be able to decrease the virus susceptibility of honey bees. Survival differences may be related to differences in the natural immune system of honey bees and could relate to how much virus stress bees have experienced in the past. Abstract Among numerous viruses that infect honey bees (Apis mellifera), Israeli acute paralysis virus (IAPV) can be linked to severe honey bee health problems. Breeding for virus resistance may improve honey bee health. To evaluate the potential for this approach, we compared the survival of IAPV infection among stocks from the U.S. We complemented the survival analysis with a survey of existing viruses in these stocks and assessing constitutive and induced expression of immune genes. Worker offspring from selected queens in a common apiary were inoculated with IAPV by topical applications after emergence to assess subsequent survival. Differences among stocks were small compared to variation within stocks, indicating the potential for improving honey bee survival of virus infections in all stocks. A positive relation between worker survival and virus load among stocks further suggested that honey bees may be able to adapt to better cope with viruses, while our molecular studies indicate that toll-6 may be related to survival differences among virus-infected worker bees. Together, these findings highlight the importance of viruses in queen breeding operations and provide a promising starting point for the quest to improve honey bee health by selectively breeding stock to be better able to survive virus infections.
The microbiome in urinary tract infections in children - an update.

PURPOSE OF REVIEW Urinary tract infection (UTI) is one of the most common pediatric infections worldwide. Recently introduced 16S rRNA sequencing allows detailed identification of bacteria involved in UTI on a species-based level. The urogenital microbiome in children is scarcely investigated, with underlying conditions differing from adults. Improvement in diagnostic and therapeutic approaches can help to minimize unnecessary antibiotic treatments, thereby protecting the physiological microbiome. RECENT FINDINGS Healthy bladders of children display a distinct microbiome than those of adults. UTI is characterized by changes in bacterial composition, with a high prevalence of Enterobacterales. There is a correlation between bacterial species and the pH of the urine, so a characteristic age-related pathogen pattern can be found due to the acidic urine in infants and more alkaline urine in older children. Recently, new methods were proposed to overcome the suboptimal diagnostic performance of urine cultures and urine dipstick test. This allows precise treatment decisions and helps to prevent chronification of UTI, related voiding dysfunctions and renal scaring, systemic abiosis, and the development of antibiotic resistance. SUMMARY Uropathogens involved in UTIs in children should be identified with precision to allow targeted therapeutic decisions. This can also help preventing the destruction of the microbiome homeostasis, which could result in a life-long dysbiosis. New treatment approaches and recolonization with probiotics are necessary due to increasing intrinsic antibiotic resistance of bacteria.
Acceleration, Deceleration and Dynamic Stress Load in Elite Hurling: A Between-Quarter and Between-Position Comparison

This study described the decrement in accelerations, decelerations and dynamic stress load (DSL) between quarters in elite hurling. GPS (10-Hz) were used to record data from 42 players over 22 games (2018–2020 season). The number of accelerations and decelerations and DSL between quarters were assessed. Accelerations and decelerations were greater in Q1 than Q2 (ES = 0.28 and ES = 0.44, respectively), and Q4 (ES = 0.57 and ES = 0.60, respectively), and in Q3 compared to Q4 (ES = 0.50 and ES = 0.44, respectively). The DSL was 56 ± 21 AU in Q1, 56 ± 20 AU in Q2, 52 ± 20 AU in Q3 and 56 ± 24 AU in Q4. There was a decrease in DSL in Q3 compared to Q1 (ES = −0.20) and Q2 (ES = −0.20). Each position experienced a temporal decrease in at least one quarter (ES = 0.43–1.46) in all metrics except full-backs’, half-backs’ and full forwards’ accelerations, midfielders’ decelerations and midfielders’ and half forwards’ DSL. Current data show temporal decrements in running performance in Q2 and Q4 and DSL in Q3. Players should be conditioned to minimize the drop-off in running performances following the third quarter.