Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimization of the Physical and Mechanical Properties of Grouting Material for Non-Soil-Squeezing PHC Pipe Pile

The physical and mechanical properties of grouting materials greatly affect the friction resistance and the bearing performance of a non-soil-squeezing PHC pipe pile. Orthogonal tests for four factors at five levels were carried out to optimize the proportion of the water–cement mixture by using Portland cement as a raw material and a water-reducing agent, expansion agent and early-strength agent as additives. The following conclusions were obtained: (1) Both the water–cement ratio and the dosage of water-reducing agent are positively correlated with the fluidity of the water–cement mixture and have the greatest influence on the fluidity, followed by the expansion agent and early-strength agent. The saturation point of the water-reducing agent is 1.5%. (2) The strength of the grouting body decreases linearly with the increase of the water–cement ratio, and the dosage of the water-reducing agent has no obvious effect on the strength. As the dosage of expansion agent increases, the strength of the grouting body decreases rapidly. The expansion agent mainly plays a key role in the middle and late stages of the hardening process of the slurry. Early-strength agents have a greater impact on the early strength, but less on the later strength. When the slurry is solidified for 3 h, the early-strength agent has the greatest impact on the strength with an optimal dosage of 5%. (3) The volume of the grouting body has an inverse relationship with the water–cement ratio, and the optimal amount of expansion agent is 12%. The incorporation of an expansion agent makes the volume increase of the grouting body exceed the volume shrinkage ratio caused by the hardening of the grouting body with a curing time of more than 3 days, ensuring a slight increase in the volume of the grouting body. After 3 days, even though the effect of the expansion agent is gradually weakened, it can still ensure that the volume of the grouting body does not shrink. With the increase of the amount of water-reducing agent, the volume of the grouting body gradually decreases. When the amount of water-reducing agent exceeds 1.5%, the volume of the grouting body no longer decreases. (4) The early-strength agent has almost no effect on the volume of the grouting body. When the curing time is 3 h, the water–cement ratio has the greatest influence on the volume of the grouting body, followed by the water-reducing agent, and, finally, the expansion agent. After 3 h, the water–cement ratio still has the greatest influence, and the influence of the expansion agent gradually exceeds that of the water-reducing agent. The water-reducing agent mainly affects the volume of the grouting body in the water separation stage, and the expansion agent mainly plays a role in the middle and late stages of the slurry solidification. After optimized ratio analysis, the fluidity of the water–cement mixture can be improved, the volume shrinkage ratio rate can be lowered and the early strength can be increased.
WATER REQUIREMENTS OR WATER DEMANDS

The terms "water requirements" and "water demands" are frequently used interchangeably. In the language of economics, however, these words have special meanings. Here is the first of four articles by these authors that delve into water demand. THE nicipal SUPPLY water has of developed, high-quality princimunicipal water has developed, principally in the last century, into one of the largest industries in the US. At the present time, more than 170 million Americans are served by public water systems. In terms of the size and value of the physical plant necessary to render that service, the water-utility industry is second only to the electricpower industry. The current replacement value of public-water-supply systems throughout the country is in excess of $50 billion, which is equivalent to an investment of $339,000 per employee, substantially higher than the comparable statistic for any other industry. (Replacement value of water-utility facilities was obtained from an AWWA
Numerical Study on a Dominant Mechanism of Rip Current at Haeundae Beach: Honeycomb Pattern of Waves

Two regular progressive wave trains, the directions of which are slightly different from each other, develop a honeycomb pattern of wave crests due to their nonlinear interaction. In the honeycomb pattern of wave crest, the nodal line area, which has very low wave energy, is formed. When the honeycomb pattern is developed near the beach area, rip current evolves through the nodal line area formed in the cross shore direction. In this study, to confirm that the formation of honeycomb pattern of waves near the beach area is a dominant mechanism of rip current occurred at Haeundae beach, we performed a numerical simulation of nearshore circulation at Haeundae beach under an unidirectional and monochromatic wave condition by using a nonlinear Boussinesq equation model. As a result, wave refraction due to topographical characteristics (i.e., submerged shoal) of Haeundae gave rise to several wave trains propagating with slightly different directions toward the beach, and consequently rip currents well developed through the nodal line area of honeycomb patterns of wave crest. In addition, we found that a narrow-banded spectral wave condition (i.e., a swell spectrum) increases more likelihood of rip current than a broad-banded spectral wave condtion based on the simulations employing various wave spectra with an equivalent wave height and period.
Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial.
Evaluation of The Local Scour Around GroupPiers (Babil Bridge as Case Study)

The hydraulic bridges are one of the important structures that must be protected from the failure by continuous monitoring. Hence, this study is about the most common causes of bridges failure which is the local scour. In this research Hydrologic Engineering Center River Analysis System (HEC-RAS) program will be used to evaluate local scour around group piers of Babil Bridge in the middle of Iraq. It was found that the HEC-RAS model is a good tool for predicting local scour depth for bridge piers. Where found that the computed scour depth from HEC-RAS program compares well with the observed value. The local scour depth at group piers of Babil Bridge were calculated and found that the piers of the bridge are safe against scouring in the present time because the depth of the maximum local scour is less than the depth of foundation of the bridge.
The effect of hedonic value, utilitarian value, and customer satisfaction in predicting repurchase intention and willingness to pay a price premium for smartwatch brands

The aim of this study is to examine the role of hedonic value (HV), utilitarian value (UV), and customer satisfaction (CS) in individuals' willingness to pay a price premium (WTP a price premium) and repurchase intention (RI) to smartwatches. This study is unique and important as it only deals with smartwatches, unlike other studies on wearable technology products that often focus on the general situation. The research sample includes smartwatch users aged 18 years and above. An online survey was used to collect research data from 420 people identified using the convenience sampling method. After checking the missing values, 401 valid surveys were retained for further analysis. Hypotheses were analysed using the Structural Equation Modelling. The research findings revealed strong relationships between HV and UV and CS. HV and UV were found to positively affect the CS. The results showed that CS also had a positive influence on both WTP a price premium and RI.
Effective Double Electron Transport Layer Inducing Crystallization of Active Layer for Improving the Performance of Organic Solar Cells

Interface modification plays an important role in enhancing the photoelectric conversion efficiency and stability of organic solar cells. In this work, alkali metal lithium chloride (LiCl) was introduced between indium tin oxide and polyethyleneimine ethoxylate (PEIE) to prepare a double-layer electron transport layer. Results show that the introduction of LiCl has dual functions. The first function is that LiCl can enhance conductivity, thereby facilitating charge collection. The second function is that the double-layer electron transport layer based on LiCl can induce the crystallization of active layer, thereby enhancing charge transport. Devices with LiCl/PEIE double layer achieve a high power conversion efficiency (PCE) of 3.84%, which is 21.5% higher than that of pristine devices (the PCE of pristine devices with pure PEIE interface layer is 3.16%).
Evolution of Enterococcus faecium to A Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies

Infections caused by vancomycin-resistant Enterococcus faecium (VREfm) are an important public health threat. VREfm have become increasingly resistant to the front-line antibiotic, daptomycin (DAP). As such, the use of DAP combination therapies (like fosfomycin [FOS]), has received increased attention. Antibiotic combinations could extend the efficacy of current available antibiotics and potentially delay the onset of further resistance. We investigated the potential for E. faecium HOU503, a clinical VREfm isolate that is DAP and FOS susceptible, to develop resistance to a DAP-FOS combination. Of particular interest was whether the genetic drivers for DAP-FOS resistance might be epistatic and, thus, potentially decrease the efficacy of a combinatorial approach in either inhibiting VREfm or in delaying the onset of resistance. We show that resistance to DAP-FOS could be achieved by independent mutations to proteins responsible for cell wall synthesis for FOS and in altering membrane dynamics for DAP. However, we did not observe genetic drivers that exhibited substantial cross-drug epistasis that could undermine DAP-FOS combination. Of interest was that FOS resistance in HOU503 was largely mediated by changes in phosphoenolpyruvate (PEP) flux as a result of mutations in pyruvate kinase (pyk). Increasing PEP flux could be a readily accessible mechanism for FOS resistance in many pathogens. Importantly, we show that HOU503 were able to develop DAP resistance through a variety of biochemical mechanisms and were able to employ different adaptive strategies. Finally, we showed that the addition of FOS can prolong the efficacy of DAP, significantly extending the timeline to resistance in vitro. Importance While the discovery of antibiotics was one of the greatest health care advances in history, its success is being challenged by the emergence of multidrug-resistant pathogens, including vancomycin-resistant enterococci (VRE). Daptomycin (DAP), a lipopeptide antibiotic that targets cell membrane, is currently prescribed as a frontline drug to treat VRE infections. However, emergence of daptomycin-resistant VRE is concerning. Consequently, DAP-Fosfomycin (FOS) combination (DF) has been proposed as a potential method to maintain DAP efficacy. Here, we provide evidence that DF successfully delayed the emergence of resistance in vitro. Genetic data indicates that resistance was acquired independently, with little evidence of significant cross-drug epistasis that could undermine a combinatorial approach. We also uncovered a novel FOS resistance mechanism, through changes in phosphoenolpyruvate (PEP) flux, that may potentially be shared with other bacterial species. Additionally, we also have evidence showing that E. faecium was able to employ different resistance mechanisms.
Community-Acquired Pneumonia Requiring Hospitalization among French Guianese Children

Community-acquired pneumonia remains a leading cause of hospitalizations among children worldwide. The diagnosis is based on the history, the physical examination results in children with fever plus respiratory signs and symptoms, and chest radiography. The microbiological etiology is confirmed by viral testing and hemocultures. The most likely etiology depends on the age of the child. The features of childhood pneumonia vary between countries and territories. The purpose of this study was to describe the epidemiological characteristics and current microbial ecology of community-acquired pneumonia in children in French Guiana. We performed a retrospective, descriptive, and monocentric study between January 1, 2015, and December 31, 2017, in the pediatric ward of the Cayenne Hospital in French Guiana. The studied population was aged from 0 to 15 years and 3 months and hospitalized for acute community-acquired pneumonia. A total of 415 patients (mean age 3.62 years) were included. A pathogen was identifiable in 22.4% of cases, including bacteria in 61.3%, viruses in 43%, and coinfections in 14%. The main pathogens were respiratory syncytial virus (31.2%), Streptococcus pneumoniae (20.4%), Haemophilus influenzae (11.8%), and Mycoplasma pneumoniae (10.8%). The burden of hospitalization for children with community-acquired pneumonia was highest among less than 2 years, in whom respiratory viruses were the most commonly detected causes of pneumonia. The share of vaccine-preventable diseases (S. pneumoniae, H. influenzae, and influenza) remains high. With the vaccination requirement imposed since 1 January 2018 against pneumococcus, Haemophilus influenzae, and whooping cough and the possibility of practicing multiplex PCR in our hospital, it will be interesting to study the impact of this law enforcement on new child generations and compare these new data to our study.
Differential Hemodynamic Response of Pial Arterioles Contributes to a Quadriphasic Cerebral Autoregulation Physiology

Background Cerebrovascular autoregulation (CA) regulates cerebral vascular tone to maintain near‐constant cerebral blood flow during fluctuations in cerebral perfusion pressure (CPP). Preclinical and clinical research has challenged the classic triphasic pressure‐flow relationship, leaving the normal pressure‐flow relationship unclear. Methods and Results We used in vivo imaging of the hemodynamic response in pial arterioles to study CA in a porcine closed cranial window model during nonpharmacological blood pressure manipulation. Red blood cell flux was determined in 52 pial arterioles during 10 hypotension and 10 hypertension experiments to describe the pressure‐flow relationship. We found a quadriphasic pressure‐flow relationship with 4 distinct physiological phases. Smaller arterioles demonstrated greater vasodilation during low CPP when compared with large arterioles (P<0.01), whereas vasoconstrictive capacity during high CPP was not significantly different between arterioles (P>0.9). The upper limit of CA was defined by 2 breakpoints. Increases in CPP lead to a point of maximal vasoconstriction of the smallest pial arterioles (upper limit of autoregulation [ULA] 1). Beyond ULA1, only larger arterioles maintain a limited additional vasoconstrictive capacity, extending the buffer for high CPP. Beyond ULA2, vasoconstrictive capacity is exhausted, and all pial arterioles passively dilate. There was substantial intersubject variability, with ranges of 29.2, 47.3, and 50.9 mm Hg for the lower limit, ULA1, and ULA2, respectively. Conclusions We provide new insights into the quadriphasic physiology of CA, differentiating between truly active CA and an extended capacity to buffer increased CPP with progressive failure of CA. In this experimental model, the limits of CA widely varied between subjects.
MiR-126-HMGB1-HIF-1 Axis Regulates Endothelial Cell Inflammation during Exposure to Hypoxia-Acidosis

Crosstalk between molecular regulators miR-126, hypoxia-inducible factor 1-alpha (HIF-1-α), and high-mobility group box-1 (HMGB1) contributes to the regulation of inflammation and angiogenesis in multiple physiological and pathophysiological settings. Here, we present evidence of an overriding role for miR-126 in the regulation of HMGB1 and its downstream proinflammatory effectors in endothelial cells subjected to hypoxia with concurrent acidosis (H/A). Methods. Primary mouse endothelial cells (PMEC) were exposed to hypoxia or H/A to simulate short or chronic low-flow ischemia, respectively. RT-qPCR quantified mRNA transcripts, and proteins were measured by western blot. ROS were quantified by fluorogenic ELISA and luciferase reporter assays employed to confirm an active miR-126 target in the HMGB1 3′UTR. Results. Enhanced expression of miR-126 in PMECs cultured under neutral hypoxia was suppressed under H/A, whereas the HMGB1 expression increased sequentially under both conditions. Enhanced expression of HMGB1 and downstream inflammation markers was blocked by the premiR-126 overexpression and optimized by antagomiR. Compared with neutral hypoxia, H/A suppressed the HIF-1α expression independently of miR-126. The results show that HMGB1 and downstream effectors are optimally induced by H/A relative to neutral hypoxia via crosstalk between hypoxia signaling, miR-126, and HIF-1α, whereas B-cell lymphoma 2(Bcl2), a HIF-1α, and miR-126 regulated gene expressed optimally under neutral hypoxia. Conclusion. Inflammatory responses of ECs to H/A are dynamically regulated by the combined actions of hypoxia, miR-126, and HIF-1α on the master regulator HMGB1. The findings may be relevant to vascular diseases including atherosclerotic occlusion and interiors of plaque where coexisting hypoxia and acidosis promote inflammation as a defining etiology.
The Effect of Advanced Age on the Electrode-Neuron Interface in Cochlear Implant Users

Objectives: This study aimed to determine the effect of advanced age on how effectively a cochlear implant (CI) electrode stimulates the targeted cochlear nerve fibers (i.e., the electrode-neuron interface [ENI]) in postlingually deafened adult CI users. The study tested the hypothesis that the quality of the ENI declined with advanced age. It also tested the hypothesis that the effect of advanced age on the quality of the ENI would be greater in basal regions of the cochlea compared to apical regions. Design: Study participants included 40 postlingually deafened adult CI users. The participants were separated into two age groups based on age at testing in accordance with age classification terms used by the World Health Organization and the Medical Literature Analysis and Retrieval System Online bibliographic database. The middle-aged group included 16 participants between the ages of 45 and 64 years and the elderly group included 24 participants older than 65 years. Results were included from one ear for each participant. All participants used Cochlear Nucleus CIs in their test ears. For each participant, electrophysiological measures of the electrically evoked compound action potential (eCAP) were used to measure refractory recovery functions and amplitude growth functions (AGFs) at three to seven electrode sites across the electrode array. The eCAP parameters used in this study included the refractory recovery time estimated based on the eCAP refractory recovery function, the eCAP threshold, the slope of the eCAP AGF, and the negative-peak (i.e., N1) latency. The electrode-specific ENI was evaluated using an optimized combination of the eCAP parameters that represented the responsiveness of cochlear nerve fibers to electrical stimulation delivered by individual electrodes along the electrode array. The quality of the electrode-specific ENI was quantified by the local ENI index, a value between 0 and 100 where 0 and 100 represented the lowest- and the highest-quality ENI across all participants and electrodes in the study dataset, respectively. Results: There were no significant age group differences in refractory times, eCAP thresholds, N1 latencies or local ENI indices. Slopes of the eCAP AGF were significantly larger in the middle-aged group compared to the elderly group. There was a significant effect of electrode location on each eCAP parameter, except for N1 latency. In addition, the local ENI index was significantly larger (i.e., better ENI) in the apical region than in the basal and middle regions of the cochlea for both age groups. Conclusions: The model developed in this study can be used to estimate the quality of the ENI at individual electrode locations in CI users. The quality of the ENI is affected by the location of the electrode along the length of the cochlea. The method for estimating the quality of the ENI developed in this study holds promise for identifying electrodes with poor ENIs that could be deactivated from the clinical programming map. The ENI is not strongly affected by advanced age in middle-aged and elderly CI users.
Analysis of COVID-19 Vaccine Type and Adverse Effects Following Vaccination

Key Points Question What factors are associated with adverse effects after COVID-19 vaccination? Findings In an online cohort study including 19 586 adults who received a COVID-19 vaccination, the factors most strongly associated with adverse effects were full vaccination dose, brand of vaccine, younger age, female sex, and having had COVID-19 before vaccination. Allergic reaction or anaphylaxis was reported in 0.3% of participants after partial vaccination and 0.2% of participants after full vaccination. Meaning These findings suggest that some individuals experience more adverse effects after COVID-19 vaccination, but serious adverse effects are rare.