Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of bla LAP-2 and qnrS 1 genes in the internationally successful Klebsiella pneumoniae ST 147 clone

We investigated the presence of b-lactamase genes (bla) in 26 strains of Enterobacteriaceae already found positive for the qnrS1 gene, a plasmid-mediated quinolone resistance determinant. Three strains of K. pneumoniae, isolated in the period 2008–2009 at the University Hospital in Verona, were positive for LAP-2, a narrow-spectrum b-lactamase. These strains, namely VRB586, VRE185 and VRE196, were cultured from urine, bile and peritoneal drainage, respectively, of different patients from different units. The blaLAP-2 and qnrS1 resistance determinant genes were separated by ISEcl2 and were located on a 97 kb conjugable and untypable plasmid, which could be transferred to a recipient strain, E. coli J53. The fluoroquinolone and ceftazidime MICs increased 1–2-fold in the transconjugant cells. The three K. pneumoniae strains were found to be clonal by PFGE and were identified as belonging to ST147, an internationally successful clone, by MLST. The plasmid sequence, including ISEcl2 and qnrS1 genes, of K. pneumoniae ST147 was found to be highly similar to previously detected qnrS1-harbouring plasmids, suggesting the plasmid has a stable genetic structure and that these resistance determinants have a common source. To the best of our knowledge, this is the first report of the internationally successful K. pneumoniae ST147 strain carrying blaLAP-2 and qnrS1 genes and is the first case of LAP blactamase in Italy.
Norms of exchange and the socio-economics of labour markets

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A Note On The Cross-Section Of Stock Returns On The Istanbul Stock Exchange

This paper investigates the explanatory powers of firm size, book-to-market, sales-to-price, debt-toequity ratio, and dividend yield on the cross-section of returns on the Istanbul Stock Exchange (ISE). Our results indicate that each of these variables (except dividend yield), commands a significant return premium when included in a simple regression model with the highest premium being associated with sales-to-price ratio. Our results suggest that sales-to-price ratio and debt-to-equity ratio have higher explanatory powers on the cross-sectional variability of returns on the ISE than firm size and book-tomarket ratio, firm-specific variables that are documented to have the greatest explanatory power on the cross-section of U.S. stock returns (Fama and French, 1992).
Mission Match and Organizational Satisfaction: Testing the Mediating Role of Perceived Reputation

Motivational research has become one of the major topics in public administration. However, public administration researchers have focused disproportionately on public service motivation in accounting for behaviors/attitudes in the public sphere. Somewhat neglected are the different, but no less important, motivations that impact the everyday operations of government employees. To narrow the gap, this study examines the effect of motivations based on organizational mission (mission match) and perceived organizational reputation. Using a large-N sample of U.S. federal employees, results show that mission-matched employees are more likely to be satisfied with their organization. This relationship is mediated through perceived organizational reputation. This study discuss the contributions of introducing organizational reputation as a contextual factor that intervenes in bureaucratic motivation and raise questions for further inquiry.
Is vacuum assisted closure dressing better than conventional management of diabetic wounds

Foot ulcers are a major cause of hospitalization in patients with Diabetes Mellitus (DM) which increases hospital stay because of multiple surgical procedures, prolonged length of stay. Diabetics have 25% risk of developing a foot ulcer, which precedes amputation in up to 85% of cases. The management of the DFU is largely determined by its severity (grade), vascularity of the limb, and the presence (6-8) of infection.
A Sparsity-Aware Fault Diagnosis Framework Focusing on Accurate Isolation

In this article, we propose an efficient fault diagnosis framework to achieve accurate fault isolation. The core is to introduce the <inline-formula><tex-math notation="LaTeX">$\ell _{2,0}$</tex-math></inline-formula>-norm sparsity constrained optimization to reduce the variable redundancy and determine the variable number, which is different from the existing sparse variants. In order to illustrate the idea, this article takes principal component analysis (PCA) as an essential step. First, a sparsity-aware PCA is constructed by taking advantage of the <inline-formula><tex-math notation="LaTeX">$\ell _{2,0}$</tex-math></inline-formula>-norm constrained optimization. Afterward, a two-stage monitoring strategy is designed, including fault detection and fault isolation. Once the fault is detected, the sparsity level is then shrunk to achieve accurate fault isolation. Moreover, an alternating direction method of multipliers-based optimization algorithm is developed with detailed implementation. Finally, the detection improvement and accurate isolation performance are validated by two simulated examples, the Tennessee Eastman benchmark process, and a practical cylinder-piston process.
The effectiveness of the Incredible Years pre-school parenting programme in the United Kingdom: a pragmatic randomised controlled trial

ABSTRACT The prognosis for children with early-onset conduct disorder is poor. Conduct disorder also has a social cost for families and communities, and an economic cost for society through the increased use of health, education, social, legal and detention services. In this study, the Incredible Years (IY) BASIC programme was delivered to parents of pre-school children at risk of developing a conduct disorder and evaluated by pragmatic randomised controlled trial. Participants were parents of 161 children (110 intervention, 51 control) aged between 36 and 59 months (mean age 44 months, 63% boys) and scoring over the clinical cut-off on the Strengths and Difficulties Questionnaire (SDQ). At follow-up (six months post-baseline), the intent-to-treat analysis showed a mean between group difference in favour of IY on the SDQ total difficulties score of 2.23 (p < 0.05, effect size: 0.50). IY was also superior to control on the Eyberg Child Behaviour Inventory (p < 0.05, effect size: 0.37) and on the Arnold and O’Leary parenting scale (p < 0.01, effect size: 0.43). This study confirms the effectiveness of IY in a public system delivered with fidelity by regular children’s centre staff, supporting findings from a similar trial in Wales. These results support the wider roll-out of IY to similar children.
Business Unit Controller Involvement in Management: An Empirical Study in the Netherlands

In recent years there has been much debate on the new business-oriented role of management accountants, also called controllers. The purpose of this paper is to investigate to what extent the involvement of the business unit (BU) controller in the decision-making process of business units is impacted not only by organizational factors, but also by the personal characteristics of BU controllers. This exploratory study provides further insight into the various roles of BU controllers. Survey data from 119 BU controllers in Dutch multidivisional organizations indicate that Controller Involvement in Management (CIM) takes two different forms: CIM in strategic decisions and CIM in operating decisions. CIM by BU controllers in strategic decisions is positively related to the degree of decentralization and the stability of performance of the business unit. CIM in strategic decisions is also positively related to more extravert BU controllers. The degree of CIM in operating decisions is related to interdependencies between business units and to strict hierarchical relationships between BU controllers and their BU managers or the corporate controller. CIM in operating decisions is positively related to BU controllers who are 'open to new experience' but negatively related to BU controllers who are tolerant and 'accepting towards others'. This study shows that the personal characteristics of BU controllers do actually matter in CIM in both strategic and operating decisions.
Z Score Estimation for Indian Banking Sector

From traditional times the Z score values have been constantly used for prediction of Bankruptcy. This has been vital to both the lenders and investors whose returns are based on solvency estimates. The terms of credit have gone a U turn from the traditional times to the modern scenario today. The basic concern of prediction is to evaluate the terms of credit and ensure repayment safely. Z score has been used as a tool to evaluate the credibility of the firms. This paper provides the Z score value for the public sector banks. This value is useful when these banks demand loans from the RBI or any other funding agency. The usage of back propagation neural network is to forecast the internal parameters of Z score and then use these internal parameters to forecast the Z score value up to 2020. Thus the paper emphasizes the usage of BPNN for prediction of bankruptcy for public sector banks in India.  Looking into the scenario of business today the enhancing uncertainty scenario takes away the surety of existence from firms. Perhaps to be sure of the longevity of the firm becomes the prime issue of concern by all the business houses. The viability of banks holds prime importance as it relates to financial investments, funding, capacity building and expansion by ploughing back profits. Z score has been used as a tool to evaluate the credibility of the firms. This paper provides the Z score value for the public sector banks. This value is useful when these banks demand loans from the RBI or any other funding agency. The usage of back propagation neural network is to forecast the internal parameters of Z score and then use these internal parameters to forecast the Z score value up to 2020. Thus the paper emphasizes the usage of BPNN for prediction of bankruptcy for public sector banks in India. The research focus on three banks that are considered in the big, medium and small capital norms being Oriental Bank of Commerce, Punjab National Bank and State Bank of India. The paper is divided into sections. Section I gives the introduction about the research done in the paper, Section II discusses the bankruptcy scenario related to Z score, Section III describes the model design and methodology, Section IV discusses the BPNN Model application in Z Score for Public Sector banks in India, Section V evaluates the predictions of internal parameters of Z score, Section VI brings forth the findings and the last Section VII sums up the research.
The Role of Trait Emotional Intelligence in Individual Performance: A Descriptive Study in Albaha University, Saudi Arabia

The current study investigates the relationship between emotional intelligence and individual performance, namely academic performance. It also aims at determining whether emotional intelligence differs between male and female students. The data were obtained through the Schutte Self-Report Emotional Intelligence (SSREI) questionnaire, which was distributed to undergraduate students in Albaha province, Saudi Arabia. A sample of 191 undergraduate students filled in (SSREI), which included the demographic and academic performance measures. The results indicated that the relationship between emotional intelligence and academic performance was not statistically significant. Moreover, no statistically significant difference was found between male and female students in the total of emotional intelligence score.
Immunotherapy and Antivascular Targeted Therapy in Patients' Treatment with Concurrent Malignant Tumors after Organ Transplantation: Opportunity or Challenge

Objective To analyze the therapeutic effects and organ rejection of anti-PD-1 immunotherapy or antivascular targeting therapy on patients with combined malignancies after organ transplantation. Methods We collected retrospective studies on “post-transplantation, cancer, immunotherapy, and vascular targeting therapy” in Embase, Wanfang database, Cochrane Library, VIP databases, CNKI, and PubMed, and the case data were organized and analyzed. Results Data from only 40 papers met our requirements, which included 2 literature reviews, 4 original researches, and 34 case reports from 2016 to 2020. A total of 40 studies involving 66 patients were included, who were divided into 3 groups (patients using CTLA-4 inhibitors, group 1; patients who received sequential or concurrent anti-PD-1 and anti-CTLA-4 therapy, group 2; and patients using PD-1/PD-L1 inhibitors, group 3). There was no statistical difference in patients' DCR between the three groups (P > 0.05). Also, compared with group 2, there was no statistically significant difference in recipient organ rejection in group 1 and group 3 (P > 0.05). The DCR rate for antivascular targeted therapy is approximately 60%. Conclusions Immunotherapy should be carefully selected for patients with combined malignancies after organ transplantation. Antivascular targeted therapy is one of the options worth considering; the risk of side effects of drug therapy is something that needs to be closely monitored when combined with immunotherapy.
Prediction of earthquake ground motion at rock sites in Japan: evaluation of empirical and stochastic approaches for the PEGASOS Refinement Project

S U M M A R Y Strong ground-motion databases used to develop ground-motion prediction equations (GMPEs) and calibrate stochastic simulation models generally include relatively few recordings on what can be considered as engineering rock or hard rock. Ground-motion predictions for such sites are therefore susceptible to uncertainty and bias, which can then propagate into sitespecific hazard and risk estimates. In order to explore this issue we present a study investigating the prediction of ground motion at rock sites in Japan, where a wide range of recording-site types (from soil to very hard rock) are available for analysis. We employ two approaches: empirical GMPEs and stochastic simulations. The study is undertaken in the context of the PEGASOS Refinement Project (PRP), a Senior Seismic Hazard Analysis Committee (SSHAC) Level 4 probabilistic seismic hazard analysis of Swiss nuclear power plants, commissioned by swissnuclear and running from 2008 to 2013. In order to reduce the impact of site-to-site variability and expand the available data set for rock and hard-rock sites we adjusted Japanese ground-motion data (recorded at sites with 110 m s−1 < Vs30 < 2100 m s−1) to a common hard-rock reference. This was done through deconvolution of: (i) empirically derived amplification functions and (ii) the theoretical 1-D SH amplification between the bedrock and surface. Initial comparison of a Japanese GMPE’s predictions with data recorded at rock and hard-rock sites showed systematic overestimation of ground motion. A further investigation of five global GMPEs’ prediction residuals as a function of quarter-wavelength velocity showed that they all presented systematic misfit trends, leading to overestimation of median ground motions at rock and hard-rock sites in Japan. In an alternative approach, a stochastic simulation method was tested, allowing the direct incorporation of site-specific Fourier amplification information in forward simulations. We use an adjusted version of the model developed for Switzerland during the PRP. The median simulation prediction at true rock and hard-rock sites (Vs30 > 800 m s−1) was found to be comparable (within expected levels of epistemic uncertainty) to predictions using an empirical GMPE, with reduced residual misfit. As expected, due to including site-specific information in the simulations, the reduction in misfit could be isolated to a reduction in the site-related within-event uncertainty. The results of this study support the use of finite or pseudo-finite fault stochastic simulation methods in estimating strong ground motions in regions of weak and moderate seismicity, such as central and northern Europe. Furthermore, it indicates that weak-motion data has the potential to allow estimation of betweenand within-site variability in ground motion, which is a critical issue in site-specific seismic hazard analysis, particularly for safety critical structures.
Genome-Wide Identification and Characterization of the Calmodulin-Binding Transcription Activator (CAMTA) Gene Family in Plants and the Expression Pattern Analysis of CAMTA3/SR1 in Tomato under Abiotic Stress

Calmodulin-binding transcription activator (CAMTA) plays an important regulatory role in plant growth, development, and stress response. This study identified the phylogenetic relationships of the CAMTA family in 42 plant species using a genome-wide search approach. Subsequently, the evolutionary relationships, gene structures, and conservative structural domain of CAMTA3/SR1 in different plants were analyzed. Meanwhile, in the promoter region, the cis-acting elements, protein clustering interaction, and tissue-specific expression of CAMTA3/SR1 in tomato were identified. The results show that SlCAMTA3/SR1 genes possess numerous cis-acting elements related to hormones, light response, and stress in the promoter regions. SlCAMTA3 might act together with other Ca2+ signaling components to regulate Ca2+-related biological processes. Then, the expression pattern of SlCAMTA3/SR1 was also investigated by quantitative real-time PCR (qRT-PCR) analysis. The results show that SlCAMTA3/SR1 might respond positively to various abiotic stresses, especially Cd stress. The expression of SlCAMTA3/SR1 was scarcely detected in tomato leaf at the seedling and flowering stages, whereas SlCAMTA3/SR1 was highly expressed in the root at the seedling stage. In addition, SlCAMTA3/SR1 had the highest expression levels in flowers at the reproductive stage. Here, we provide a basic reference for further studies about the functions of CAMTA3/SR1 proteins in plants.
Depth of maximum of air-shower profiles at the Pierre Auger Observatory. I. Measurements at energies above 10(17.8) eV

We report a study of the distributions of the depth of maximum, X-max, of extensive air-shower profiles with energies above 10(17.8) eV as observed with the fluorescence telescopes of the Pierre Auger Observatory. The analysis method for selecting a data sample with minimal sampling bias is described in detail as well as the experimental cross-checks and systematic uncertainties. Furthermore, we discuss the detector acceptance and the resolution of the X-max measurement and provide parametrizations thereof as a function of energy. The energy dependence of the mean and standard deviation of the X-max distributions are compared to air-shower simulations for different nuclear primaries and interpreted in terms of the mean and variance of the logarithmic mass distribution at the top of the atmosphere.
Uncovering the natural variability of araucariacean exudates from ex situ and in situ tree populations in New Caledonia using FTIR spectroscopy

Understanding the natural variability of plant resins is crucial for evaluating the chemical information stored in ambers that may support inferring palaeoenvironmental conditions. However, even among extant resin-producing plants, the variation of resinous exudates within and between tree genera and species is still poorly understood. We analysed plant exudates from across the Araucariaceae in New Caledonia using Fourier-transform infrared spectroscopy in attenuated total reflection mode (FTIR-ATR). Both, wild (in situ) and arboretum grown (ex situ) populations were used to uncover the effects of intergeneric, inter- and intraspecific variation of the araucariacean plants on the resin chemistry. We show that even resins from the same species in the same habitat do have natural (intraspecific) chemical variation. Some of the variation can result from the degree of resin polymerisation, but this is not the only source of variation. Wild sourced resins have greater natural intraspecific chemical variation than the arboretum sourced ones. Interspecific and intergeneric differences were not easy to distinguish in the resins sampled. This has strong implications for the evaluation of the chemical information from worldwide ambers: multiple samples should be analysed to give a more accurate picture of the natural chemical variation present and how this may or may not overlap with the chemistries of other resin types. Additionally we discovered that the Araucariacean species can produce up to three distinct types of exudate (gum, resin, and gum resin). This is the first time that gum resins have been identified and characterized with FTIR-ATR. We also provide a guide on how to distinguish the exudate types when using FTIR-ATR.
The last African metatherian

Morotodon aenigmaticusgen. et sp. nov. (Mammalia, Metatheria, ? Herpetotheriidae) from the early or early-middle Miocene of equatorial Africa (Moroto II locality, Moroto District, northeastern Uganda) is characterized by a short anterior cingulum, a buccal shelf, a well-developed hypoconulid in a central position, and a trigonid and talonid with similar mesio-distal lengths. Its small size and morphology suggest mostly insectivorous-faunivorous feeding habits. The faunal association of Moroto II, as well as previous palaeoenvironmental analyses, suggest that Morotodon lived in open woodland and bushland areas surrounded by grasses. Morotodon aenigmaticus shows several features reminiscent of early herpetotheriids, such as Golerdelphys stocki (late Paleocene of North America), and Amphiperatherium ambiguum (Eocene of Europe); this suggests an origin for its lineage previous to the Oligocene. In summary, its affinities lie with Northern Hemisphere herpetotheriids, and, most probably, with European ones.
The structure of the solar convective overshooting zone

Using a non-local theory of convection, we calculated the structure of the solar convection zone, paying special attention to the detailed structure of the lower overshooting zone. Our results show that an extended transition zone exists near the bottom of the convection zone, where the temperature gradient turns smoothly from adiabatic in the convection zone to radiative in solar interior. A super-radiative temperature region is found in the overshooting zone under the solar convection zone, where L-c L and >del (rad). The extension of the super-radiative region (defined by L-r/L-circle dot greater than or equal to 1.01) l is about 0.63 H-p (0.053 R-circle dot). A careful comparison of the distribution of adiabatic sound speed and density with the local one is carried out. It is found, strikingly, that the distribution of adiabatic sound speed and density of our model is roughly consistent with the results of reversion from solar oscillation observations.