Miracle-dz/UniFAR-FTUs huggingface dataset:
-adrenergic receptors in calves change during neonatal maturation and are related to energy regulation

Catecholamines and glucocorticoids are involved in fetal maturation of organ systems to prepare the fetus for extrauterine life. Calves, especially when born preterm, depend on function of the adrenergic system and the glucocorticoid axis to adapt energy metabolism for the neonatal period. We tested the hypothesis that hepatic glucocorticoid and α 1 - and β 2 -adrenergic receptors in neonatal calves are involved in adaptation of energy metabolism around birth and that respective binding capacities depend on stage of maturation during the neonatal period. Calves (n = 7 per group) were delivered by section preterm (PT, 9 d before term) or were born at term (full-term, FT; spontaneous vaginal delivery), or spontaneously born and fed colostrum for 4 d (FTC). Blood samples were taken immediately after birth and before and 2 h after feeding at 24 h after birth (PT, FT) or on d 4 of life (FTC) to determine metabolic and endocrine changes. After slaughter at 26 h after birth (PT, FT) or on d 4 of life (FTC), liver tissue was obtained to measure hepatic binding capacity of glucocorticoid and α 1 - and β 2 -adrenergic receptors. Maximal binding capacity and binding affinity were calculated by saturation binding assays using [ 3 H]-prazosin and [ 3 H]-CGP-12177 for determination of α 1 - and β 2 -adrenergic receptors, respectively, and [ 3 H]-dexamethasone for determination of glucocorticoid receptor in liver. Additional liver samples were taken to measure mRNA abundance of glucocorticoid and α 1 - and β 2 -adrenergic receptors, of key enzymes and factors related to hepatic lipid metabolism, and of insulin-like growth factor 1 ( IGF1 ). Plasma concentrations of β-hydroxybutyrate and leptin changed with time, and leptin concentrations were affected by stage of maturation. The binding capacities for hepatic glucocorticoid and β 2 -adrenergic receptors as well as gene expression of IGF1 were greater in FTC than in FT and PT, and binding affinity for β 2 -adrenergic receptor was lowest in PT. The binding capacity of hepatic α 1 -adrenergic receptor was greatest in FTC and greater in FT than in PT. The binding capacities of glucocorticoid and α 1 - adrenergic receptors were mainly related to variables of glucose and lipid metabolism. In conclusion, our results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of α 1 -adrenergic receptor and glucocorticoid receptor with neonatal glucose and lipid metabolism
Portable respiratory polygraphy monitoring of obese mothers the first night after caesarean section with bupivacaine/morphine/fentanyl spinal anaesthesia [version 2; peer review: 2 approved]

Background: Obesity, abdominal surgery, and intrathecal opioids are all factors associated with a risk for respiratory compromise. The aim of this explorative trial was to study the apnoea/hypopnea index 1st postoperative night in obese mothers having had caesarean section (CS) in spinal anaesthesia with a combination of bupivacaine/morphine and fentanyl. Methods: Consecutive obese (BMI >30 kg/m 2) mothers, ≥18 years, scheduled for CS with bupivacaine/morphine/fentanyl spinal anaesthesia were monitored with a portable polygraphy device Embletta /NOX on 1 st postoperative night. The apnoea/hypopnea index (AHI) was identified by clinical algorithm and assessed in accordance to general guidelines; number of apnoea/hypopnea episodes per hour: <5 “normal”, ≥5 and <15 mild sleep apnoea , ≥15 and <30 moderate sleep apnoea, ≥ 30 severe sleep apnoea . Oxygen desaturation events were in similar manner calculated per hour as oxygen desaturation index (ODI). Results: Forty mothers were invited to participate: 27 consented, 23 were included, but polysomnography registration failed in 3. Among the 20 mothers studied: 11 had an AHI <5 ( normal ), 7 mothers had AHI ≥5 but <15 ( mild OSAS ) and 2 mothers had AHI ≥15 ( moderate OSA ), none had
5G vs Wifi6 Downlink Power Consumption Comparison for Teleworking Use Case

Teleworking became a vastly popular practice lately owing to the Covid-19 outbreak. Our present study aims to evaluate the operating energy consumption in 5G versus Wifi6 networks for this remote working case study. We specifically study the detailed operations of transmission and reception at both radio access networks and quantify their power consumption in the downlink, analytically, using simulations and, for the case of Wifi6. We focus on three case studies in the framework of a teleworking tool: audio session, video session and shared screen session. Our results show that for the use case of video session in the downlink, when the number of users is rather small, Wifi6 consumes less power, however, as the number of users gets larger, 5G with Multi-User MIMO (MU-MIMO) outperforms the individual Wifi accesses. These results depend on the number of simultaneous MUMIMO streams as well as on the fixed component of the power consumption of the 5G, for which we present a sensitivity analysis as well.
: Incidence, risk factors, and effects of clinical mastitis recurrence in dairy cows

Clinical mastitis (CM) is one of the most frequent and costly diseases in dairy cows. A frustrating aspect of CM is its recurrent nature. This review was conducted to synthesize knowledge on risk of repeated cases of CM, effects of recurrent CM cases, and risk factors for CM recurrence. A systematic review methodology was used to identify articles for this narrative review. Searches were performed to identify relevant scientific literature published after 1989 in English or French from 2 databases (PubMed and CAB Abstracts) and 1 search platform (Web of Science). Fifty-seven manuscripts were selected for qualitative synthesis according to the inclusion criteria. Among the 57 manuscripts selected in this review, a description of CM recurrence, its risk factors, and effects were investigated and reported in 33, 37, and 19 selected manuscripts, respectively. Meta-analysis and meta-regression analyses were used to compute risk ratio comparing risk of CM in cows that already had 1 CM event in the current lactation with risk of CM in healthy cows. For these analyses, 9 manuscripts that re-ported the total number of lactations followed and the number of lactations with ≤1 and ≤2 CM cases were used. When summarizing results from studies requiring ≥5 d between CM events to consider a CM event as a new case, we observed no significant change in CM susceptibility following a first CM case (risk ratio: 0.99; 95% confidence interval: 0.86–1.14). However, for studies using a more liberal CM recurrence definition (i.e., only 24 h between CM events to consider new CM cases), we observed a 1.54 times greater CM risk (95% confidence interval: 1.20–1.97) for cows that already had 1 CM event in the current lactation compared with healthy cows. The most important risk factors for CM recurrence were parity (i.e.
A National Scale Hybrid Model for Enhanced Streamflow Estimation - Consolidating a Physically Based Hydrological Model with Long Short-term Memory Networks

Accurate streamflow estimation is essential for effective water resources management and adapting to extreme events in the face of changing climate conditions. Hydrological models have been the conventional approach for streamflow inter/extrapolation in time and space for the past decades. However, their large-scale applications have encountered challenges, including issues related to efficiency, complex parameterization, and constrained performance. Deep learning methods, such 10 as Long Short-Term Memory networks (LSTM), have emerged as a promising and efficient approach for large-scale streamflow estimation. In this study, we conducted a series of experiments to identify optimal hybrid modelling schemes to consolidate physically based models with LSTM aimed at enhancing streamflow estimation in Denmark. The results showed that the hybrid modelling schemes outperformed the Danish Water Resources Model (DKM) in both gauged and ungauged basins. While the standalone LSTM rainfall-runoff model outperformed DKM in many basins, it faced 15 challenges when predicting streamflow in groundwater-dependent catchments. A serial hybrid modelling scheme (LSTM-q), which used DKM outputs and climate forcings as dynamic inputs for LSTM training, demonstrated higher performance. LSTM-q improved the median Nash-Sutcliffe Efficiency (NSE) by 0.18 in gauged basins and 0.11 in ungauged basins compared to DKM. Similar accuracy improvements were achieved with alternative hybrid schemes, i.e., by predicting the residuals between DKM-simulated streamflow and observations using a LSTM. Moreover, the developed hybrid models 20 enhanced the accuracy of extreme events, which encourages the integration of hybrid models within an operational forecasting framework. This study highlights the advantages of synergizing existing physically based hydrological models with LSTM models, and the proposed hybrid schemes hold the potential to achieve high-quality, large-scale streamflow estimations.
Climate change and migration

The present literature review aims to provide a panoramic view of the different ways in which the link between climate change and migration has been addressed in the existing literature, building on the recent non-annotated bibliography issued by the International Organization for Migration in December 2012. After a brief introduction of the background and the plurality of methodologies behind academic studies about the connection of the two phenomena, the review identifies four main themes and debates ongoing in the literature, namely: (1) scale and location of the climate induced migration, (2) mechanisms behind its occurrence, (3) emerging recognition of migration as adaptation, not only as an impact, and (4) measures for its management. Gaps in need of further work are divided into areas for analysis and areas for advocacy. Included among the former are more in situ knowledge production, focus on cities and additional research following a differentiated approach— e.g., gendered. Advocacy approaches need to motivate further research, maintaining advances against the stigmatization of migrants. The review is informed by human security ideas, which are presented as buttressing analyses at levels different from the national, facilitating joined-up thinking and providing a flexible framework to accommodate multiple layers of climate- migration interaction.
Clinical usefulness of the Screen for cognitive impairment in Psychiatry ( SCIP-S ) scale in patients with type I bipolar disorder

This peer-reviewed article was published immediately upon acceptance. It can be downloaded, printed and distributed freely for any purposes (see copyright notice below). Articles in HQLO are listed in PubMed and archived at PubMed Central. For information about publishing your research in HQLO or any BioMed Central journal, go to http://www.hqlo. com/info/instructions/ For information about other BioMed Central publications go to http://www.biomedcentral. com/ Health and Quality of Life Outcomes
Urinary tract Infection in Female Patients Visiting Tertiary Care Hospital and Determination of ESBL Producing MDR Isolates

Objectives: The main purpose of this study was to assess the urinary tract infection (UTI) in female patients and determine the extended spectrum of beta-lactamase producers among MDR isolates. Methods: A three-month hospital-based cross-sectional study was conducted from Marchto April 2022 at the Microbiology laboratory of Alka hospital, Lalitpur. Following the standard protocol, urine samples were taken for culture and identification. Urine samples were cultured using a semi-quantitative approach and antimicrobial susceptibility test was performed by disc diffusion method. Results: Out of 493 female urine samples examined, significant growth was found in 106 samples. The positive isolates belonged to 5 different species. Out of them E.coli (77.36%) was the major pathogens isolated followed by Klebsiella pneumoniae (6.61%), Klebsiella oxytoca and Pseudomonas aeruginosa (1.88%) as Gram negative bacteria. And the most common Gram positive bacteria was found to be Staphylococcus aureus (12.26%). The most effective drug for Gram negative isolates was Amikacin (93.396%) followed by Nitrofurantoin (91.505%). The least effective drug against Gram negative bacteria was found to be Cefexime (64.16%) and Amoxicillin (58.49%). And for Gram positive isolates Ceftazidime (100%) and Amikacin (100%) were the choice of drug showing high susceptibility. The least effective drug used against Gram positive isolates tends to be Cloxacillin (15.38%). Out of 106 isolates 63 were found to be multidrug resistant among which 31 of them were ESBL producers confirmed by cephalosporin/clavulanate double disc synergy method. The urinary tract infection was most common in the age group 20-30 (20.75%) followed by age group 30-40 (16.98%). Conclusion: UTI was least common among age groups 0-10 and 80-90 years. Bacterial isolates causing UTI had variation in the antibiotic susceptibility pattern with resistance against commonly used antibiotics which is a serious concern.
con-Lactation response to soybean meal and rumen-protected methionine supplementation of corn silage-based diets

Corn silage, an important forage fed to dairy cows in the United States, is energy rich but protein poor. The objectives of this experiment were to investigate the effects on production of milk and milk components of feeding corn silage-based diets with 4 levels of dietary crude protein (CP) plus rumen-protected methionine (RPM). Thirty-six cows were blocked by days in milk into 9 squares and randomly assigned to 9 balanced 4 × 4 Latin squares with four 4-wk periods. All diets were formulated to contain, as a percent of dry matter (DM), 50% corn silage, 10% alfalfa silage, 4% soyhulls, 2.4% mineral-vitamin supplement, and 30% neutral detergent fiber. Supplemental RPM (Mepron, Evonik Corp., Kennesaw, GA) was added to all diets to maintain a Lys: Met ratio of 3.1 in digested AA. Ground high-moisture corn was reduced and soybean meal (SBM) plus RPM increased to give diets containing, on average, 11% CP (28% corn, 31% starch, 6% SBM, 4 g of RPM/d), 13% CP (23% corn, 29% starch, 10% SBM, 8 g of RPM/d), 15% CP (19% corn, 26% starch, 15% SBM, 10 g of RPM/d), and 17% CP (14% corn, 24% starch, 19% SBM, 12 g of RPM/d). Data from the last 14 d of each period were analyzed using the mixed procedures in SAS (SAS Institute Inc., Cary, NC). With the exception of milk fat and milk lactose content, we found no significant effects of diet on all production traits. We did note linear responses to dietary CP concentration for intake, production of milk and milk components, and MUN. Cows fed the 11% CP diet had reduced DM intake, lost weight, and yielded less milk and milk components. Mean separation indicated that only true protein yield was lower on 13% CP than on 17% dietary CP, but not different between 15 and 17% CP. This indicated no improvement in production of milk and milk components above 15% CP. Quadratic trends for yield of milk, energy-corrected milk, and true protein suggested that a dietary CP concentration greater than 15% may be necessary to maximize production or, alternately, that a plateau was reached and no further CP was required. Although diet influenced apparent digestibility of DM, organic matter, and neutral detergent fiber, digestibility did not increase linearly with dietary CP. However, we observed linear and quadratic effects of dietary CP on acid detergent fiber digestibility. As expected, we found a linear effect of dietary CP on apparent N digestibility and on fecal and urinary N excretion, but no effect of diet on estimated true N digestibility. Ruminal concentrations of ammonia, total AA, peptides, and branched-chain volatile fatty acids also increased linearly with dietary CP. Quadratic responses indicated that 14.0 to 14.8% CP was necessary to optimize digestion and energy utilization. Overall results indicated that, when RPM was added to increase Lys: Met to 3.1, 15% CP was adequate for lactating dairy cows fed corn silage diets supplemented with SBM and secreting about 40 kg of milk/d; N excretion was lower than at 17% CP but with no reduction in yield of milk and milk components.
Consumer perception, health

Although the demand for goat milk products has been growing, they have lower consumer acceptability than products derived from cow milk. However, the addition of cupuassu pulp can be used to improve the formulation of these products. For this reason, the aim of this study was to investigate the influence of new goat milk yogurt manufactured with cupuassu pulp on physicochemical properties, consumers’ perceptions, and overall consumer acceptance. In addition, the effect of antioxidant health information on consumer acceptance and purchase intention of cupuassu goat milk yogurts was evaluated. The results demonstrated a positive expectation regarding linking and familiarity to goat milk products and products with cupuassu pulp. The pH, total phenolic content, lightness, redness, yellowness, and apparent viscosity were potentially affected by the addition of cupuassu, with the highest concentration of cupuassu (10%) exhibiting the greatest changes in parameters. Based on principal component analysis, partial least squares regression, and just-about-right and penalty analysis, the addition of cupuassu pulp improved some sensory attributes of goat milk yogurt, such as cupuassu aroma, cupuassu flavor, yellow color, consistency, and viscosity, which positively influenced product acceptance. In addition, antioxidant health information increased the acceptance and purchase intention of cupuassu goat milk yogurts. Taking into account the parameters investigated in this study, the best scoring formulation was goat milk yogurt with 10% cupuassu pulp. Our results suggest that cupuassu pulp can be considered a potential ingredient to improve the sensory and texture properties of goat milk yogurt. Furthermore, the antioxidant health information could be a sensory strategy to increase the acceptance of cu-puassu goat milk yogurts.
Combined ﬂuorescence and reﬂectance spectroscopy for in vivo quantiﬁcation of cancer biomarkers in low-and high-grade glioma surgery

Biomarkers are indicators of biological processes and hold promise for the diagnosis and treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked intra-and inter-tumor variability. The extent of surgical resection is a signiﬁcant factor inﬂuencing post-surgical recurrence and prognosis. Here, we used ﬂuorescence and reﬂectance spectral signatures for in vivo quantiﬁcation of multiple biomarkers during glioma surgery, with ﬂuorescence contrast provided by exogenously-induced protoporphyrin IX (PpIX) following administration of 5-aminolevulinic acid. We performed light-transport modeling to quantify multiple biomarkers indicative of tumor biological processes, including the local concentration of PpIX and associated photoproducts, total hemoglobin concentration, oxygen saturation, and optical scattering parameters. We developed a diagnostic algorithm for intra-operative tissue delineation that accounts for the combined tumor-speciﬁc predictive capabilities of these quantitative biomarkers. Tumor tissue delineation achieved accuracies of up to 94% (speciﬁcity = 94%, sensitivity = 94%) across a range of glioma histologies beyond current state-of-the-art optical approaches, including state-of-the-art ﬂuorescence image guidance. This multiple biomarker strategy opens the door to optical methods for surgical guidance that use quantiﬁcation of well-established neoplastic processes. Future work would seek to validate the predictive power of this proof-of-concept study in a separate larger cohort of patients.
Techno - Economic Assessment of Distribution System considering diﬀerent types of EVs and DGs.

The global warming crisis, together with environmental concerns, has already led governments to replace traditional fossil-fuel cars with low-emission Electric Vehicles (EVs). This replacement has resulted in the addition of a large number of EVs capable of connecting to the grid. A coordinated charging method is needed to promote EVs on a large scale while preventing grid overloading. In this work, EVs are categorized based on their battery capacity, as cars, trucks
“HIV/AIDS Isn’t Here” A Case Study of a One-Week Recreational Camp for Individuals Affected by HIV

: In this case study we examine the experiences of campers and volunteers at a one-week residential camp for individuals and families affected by HIV in Canada. The data presented was gathered during the camp session held in July 2013, and was derived from 26 interviews with campers and volunteers and from 40 self-administered surveys. This data highlights five themes: the camp as a “family” with a strong sense of community; a sense of belonging not experienced elsewhere due to stigma; the crucial role of peer social support; the camp as the intersection of diverse cultural and social groups; and reduced significance of one’s HIV status in the camp environment. This study recommends that social workers, whose caseloads include HIV-affected individuals or families, make greater use of such camps -- for example, systematic referrals, to boost social support. This article also calls on social workers to invest themselves in this type of community programming in order to enhance the quality and quantity of services offered.
Translation and Psychometric Properties of the Portuguese Version of the Timed Instrumental Activities of Daily Living (TIADL)

(1) Background: to examine the psychometric properties of the Portuguese version of the Timed Instrumental Activities of Daily Living (TIADL) in nursing home residents. (2) Methods: Fifty-two participants (85.8 ± 4.2 years) were assessed on two occasions, 10–14 days apart. The same rater administered all assessments. Internal consistency was analysed through Cronbach’s α. The reliability was estimated using the intraclass correlation coefficients (ICCs), and the standard error of the mean (SEM) was used to estimate the minimal detectable change (MDC). Construct validity was determined by Spearman’s correlation coefficients. (3) Results: For internal consistency, Cronbach’s α (0.81) revealed high internal reliability. All of the subtests demonstrated good or excellent reliability and also presented acceptable measurement precision, considering the criterion SEM < SD/2. According to Spearman’s rho, correlations with the Portuguese version of the TIADL, the Useful Field of View test, and semantic and phonemic fluency tests were significant, with moderate positive and negative correlations (0.4 < rs < 0.69). (4) Conclusions: The Portuguese version of the TIADL had good to excellent test–retest reliability (ICC > 0.90) and acceptable measurement precision. This test could be a valuable clinical tool for assessing actual performance in instrumental activities of daily living in nursing home residents.