Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcomes of fertility preservation treatments in patients with endometrial cancer with different molecular classifications based on an NGS panel

Background The molecular classification of endometrial cancer has previously been shown to be associated with clinical outcomes. However, there are insufficient data to support the routine use of molecular classification for the treatment of patients seeking fertility preservation. Methods Here, we retrospectively investigated 90 patients received fertility-sparing treatment. We used a next generation sequencing (NGS) panel to classify these patients into four subtypes. All patients received hormonal therapy combined with hysteroscopy. Therapeutic effects were evaluated by hysteroscopy every three months during the treatment. Results Patients with POLE mutations had the highest disease progression rate (50.0%, P=0.013), while the microsatellite instability-high (MSI-H) group had the highest recurrence rate (50.0%, P=0.042). PIK3CA mutation (hazard ratio (HR): 0.61; 95% confidence interval (CI): 0.37–0.99; P=0.046), overweight (HR: 0.56; 95% CI: 0.32–0.96; P=0.033) and obesity (HR: 0.44; 95% CI: 0.20–0.95; P=0.036) were associated with a significantly lower cumulative complete response (CR) rate. The combination of gonadotropin-releasing hormone analogues (GnRH-a) and letrozole (HR: 3.43; 95% CI: 1.81–6.52; P< 0.001) was associated with a significantly higher cumulative CR rate. KRAS mutation was significantly associated with disease progression (P=0.002). In wild-type TP53 patients, PTEN and PIK3CA mutations significantly prolonged the duration of treatment to achieve CR (log rank P=0.034; P=0.018). Conclusion The implementation of molecular classification for EC patients undergoing fertility-sparing treatment is promising and can facilitate the selection of appropriate medical regimes to achieve better outcomes in patients with EC who require fertility preservation treatment.
ANN-Based Ground Motion Model for Turkey using Stochastic Simulation of Earthquakes

Turkey is characterised by a high level of seismic activity attributed to its complex tectonic structure. The country has a dense network to record earthquake ground motions; however, to study previous earthquakes and to account for potential future ones, ground motion simulations are required. Ground motion simulation techniques offer an alternative means of generating region-specific time-series data for locations with limited seismic networks or regions with seismic data gaps, facilitating the study of potential catastrophic earthquakes. In this research, a local ground motion model (GMM) for Turkey is developed using region-specific simulated records, thus constructing a homogeneous dataset. The simulations employ the stochastic finite-fault approach and utilise validated input-model parameters in distinct regions, namely Afyon, Erzincan, Duzce, Istanbul, and Van. To overcome the limitations of linear regression-based models, artificial neural network (ANN) is used to establish the form of equations and coefficients. The predictive input parameters encompass fault mechanism (FM), focal depth (FD), moment magnitude (Mw), Joyner and Boore distance (RJB), and average shear wave velocity in the top 30 meters (Vs30). The dataset comprises 7359 records with Mw ranging between 5.0 and 7.5 and RJB ranging from 0 to 272 km. The results are presented in terms of spectral ordinates within the period range of 0.03 to 2.0 seconds, as well as peak ground acceleration (PGA) and peak ground velocity (PGV). The quantification of the GMM uncertainty is achieved through the analysis of residuals, enabling insights into inter- and intra-event uncertainties. The simulation results and the effectiveness of the model are verified by comparing the predicted values of ground motion parameters with the observed values recorded during previous events in the region. The results demonstrate the efficacy of the proposed model in simulating physical phenomena.
Use of Mobile Technologies in the Healthcare Industry and Business: The Case of Pulmonary Function or Breathing Test Supportive Care

Digital spirometry, which is used to monitor and diagnose both acute and chronic lung diseases, has been the subject of research for many years. This research undertakes the initiative to build a novel mobile-based digital spirometry application helpful in diagnosing diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). As part of the application’s design, it consists of hardware and software components, including a pipe in which the user can breathe into, a pressure sensor that helps to collect patients’ breaths, an Arduino board that is be responsible for processing patients’ breaths received form the pressure sensor and convert the signal to the MIDI (Musical Instrument Digital Interface) message readable by the mobile application, and finally a spirometry application developed using android studio, JAVA programming language, as a user interface. Furthermore, the database applied in this project is SQLite which utilizes cloud-based storage technology rather than server-based models which might be costly. All parts work as a circuit unit that is capable of monitoring the user’s breathing system, and processing to provide an appropriate report of its performance. According to the findings, digital spirometry based on mobile application and MIDI protocol is practical and offers all the fundamental metrics that are supported by conventional spirometers.
Cratylia argentea como suplemento de un heno de gramínea de baja calidad utilizado por ovinos

Manejo de los animales y el forraje. Se utilizaron ocho ovinos del tipo africano castrados y fistulados en el rumen y en el duodeno, con un promedio de peso vivo (PV) de 37 kg que se mantuvieron alojados en jaulas metabolicas. Los animales dentro de cada grupo se asignaron a cuatro tratamientos dispuestos en un Cuadrado Latino 4 x 4 con dos repeticiones. Los tratamientos fueron los siguientes: T1 = 100% heno de B. dictyoneura, T2 = 90% heno de B. dictyoneura + 10% leguminosa (C. argentea), T3 = 80% heno de B. dictyoneura + 20% de C. argentea, T4 = 60% heno de B. dictyoneura + 40% de C. argentea.
Antiproliferative Effects in Colorectal Cancer and Stabilisation in Cyclodextrins of the Phytoalexin Isorhapontigenin

Isorhapontigenin has been proposed as a better alternative for oral administration than the famous resveratrol, as it shares many biological activities, but with a structure that could make its delivery easier. Although this hydrophobic structure could enhance bioavailability, it could also be a disadvantage in the development of products. In this research, we study the antiproliferative activity of this stilbene against colorectal cancer and overcome its limitations through molecular encapsulation in cyclodextrins. The cytotoxic activity against human colorectal cancer cells of isorhapontigenin was similar to that of resveratrol or piceatannol, supporting its use as a bioactive alternative. The study of the encapsulation through fluorescence spectroscopy and molecular docking revealed that the complexation satisfies a 1:1 stoichiometry and that HP-β-CD is the most suitable CD to encapsulate this stilbene. Through a spectrophotometric assay, it was observed that this CD could double the basal water solubility, exceeding the solubility of other hydroxylated stilbenes. The stability of these inclusion complexes was higher at a pH below 9 and refrigeration temperatures. Moreover, the use of CDs retained more than 78% of isorhapontigenin after storage for 12 weeks, compared to 15% in free form. Overall, these findings could help design novel formulations to better deliver isorhapontigenin.
The Role of Immune Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology with limited treatment options. The role of the immune system in IPF has received increasing attention. Uncontrolled immune responses drive the onset and progression of IPF. This article provides an overview of the role of innate immune cells (including macrophages, neutrophils, mast cells, eosinophils, dendritic cells, nature killer cells, nature kill cells and γδ T cells) and adaptive immune cells (including Th1 cells, Th2 cells, Th9 cells, Th17 cells, Th22 cells, cytotoxic T cells, B lymphocytes and Treg cells) in IPF. In addition, we review the current status of pharmacological treatments for IPF and new developments in immunotherapy. A deeper comprehension of the immune system’s function in IPF may contribute to the development of targeted immunomodulatory therapies that can alter the course of the disease.
Rate of left-lateral movement along the easternmost segment of the Altyn Tagh fault, east of 96°E (China)

SUMMARY Field work carried out in Gansu province and complemented with analysis of SPOT panchromatic scenes allows us to characterize the deformations along the eastern segment of the Altyn Tagh fault and to place bounds on its Holocene left slip rate. East of 96°E, the long-term, left-lateral offset of stream channels, alluvial fans, and terrace edges is about 50 m. These offsets are most probably of Holocene age (12 ± 2 ka) and imply that the corresponding derived slip rate is 4 ± 2 mm yr−1. This observation is consistent with a north-eastward along-strike decreasing slip rate on the Altyn fault due to partitioning of slip on multiple, more easterly trending splays.
Clinical and serological findings in pregnant women and newborns: patterns of coronavirus disease 2019 placental histopathology

SUMMARY OBJECTIVE: The objective of this study was to evaluate the correlation between clinical and serological findings of pregnant women and newborns with patterns of histopathologic changes of the placenta diagnosed with coronavirus disease 2019. METHODS: A prospective descriptive study was conducted with pregnant women who were positive for SARS-CoV-2 by reverse transcription polymerase chain reaction or serology (IgG and IgM). Clinical analyses were performed using ELISA to detect anti-SARS-CoV-2 IgG and IgA antibodies using the S1 spike protein domain with the Euroimmun kit. Histopathologic analyses of placentas were performed by two expert pathologists. RESULTS: Maternal SARS-CoV-2 infection was associated with increased neonatal hospital length of stay (p=0.03), increased preterm birth (p=0.04), and Apgar score<7 at 1st min (p=0.00) and 5th min (p=0.02). Pregnant women with positive IgG and/or IgA at delivery had a higher incidence of placental histopathologic changes in addition to a greater likelihood of having an IgG-positive fetus (p<0.0001). Placentas with positive reverse transcription polymerase chain reaction for SARS-CoV-2 had a higher incidence of histopathologic changes such as maternal vascular hypoperfusion changes (p=0.00). CONCLUSION: Maternal SARS-CoV-2 infection was associated with adverse perinatal outcomes. Pregnant women with positive IgG at delivery had a higher incidence of placental histopathologic changes. Placentas with positive reverse transcription polymerase chain reaction for SARS-CoV-2 had a higher incidence of histopathologic changes such as maternal vascular hypoperfusion.
Phage selection drives resistance–virulence trade-offs in Ralstonia solanacearum plant-pathogenic bacterium irrespective of the growth temperature

Abstract While temperature has been shown to affect the survival and growth of bacteria and their phage parasites, it is unclear if trade-offs between phage resistance and other bacterial traits depend on the temperature. Here, we experimentally compared the evolution of phage resistance–virulence trade-offs and underlying molecular mechanisms in phytopathogenic Ralstonia solanacearum bacterium at 25 °C and 35 °C temperature environments. We found that while phages reduced R. solanacearum densities relatively more at 25 °C, no difference in the final level of phage resistance was observed between temperature treatments. Instead, small colony variants (SCVs) with increased growth rate and mutations in the quorum-sensing (QS) signaling receptor gene, phcS, evolved in both temperature treatments. Interestingly, SCVs were also phage-resistant and reached higher frequencies in the presence of phages. Evolving phage resistance was costly, resulting in reduced carrying capacity, biofilm formation, and virulence in planta, possibly due to loss of QS-mediated expression of key virulence genes. We also observed mucoid phage-resistant colonies that showed loss of virulence and reduced twitching motility likely due to parallel mutations in prepilin peptidase gene, pilD. Moreover, phage-resistant SCVs from 35 °C-phage treatment had parallel mutations in type II secretion system (T2SS) genes (gspE and gspF). Adsorption assays confirmed the role of pilD as a phage receptor, while no loss of adsorption was found with phcS or T2SS mutants, indicative of other downstream phage resistance mechanisms. Additional transcriptomic analysis revealed upregulation of CBASS and type I restriction-modification phage defense systems in response to phage exposure, which coincided with reduced expression of motility and virulence-associated genes, including pilD and type II and III secretion systems. Together, these results suggest that while phage resistance–virulence trade-offs are not affected by the growth temperature, they could be mediated through both pre- and postinfection phage resistance mechanisms.
Chaenothecopsis oregana New to Canada

Abstract. During field surveys in the Lower Foothills region of Lesser Slave Lake, Alberta, we collected the first Canadian record of the resinicolous calicioid fungus Chaenothecopsis oregana Rikkinen. The specimen was collected from balsam fir (Abies balsamifera) resin and resin-impregnated wood in an old growth forest. We present the first scanning electron micrographs of this species. As currently documented, the species has a disjunct distribution (Europe and western North America), but it was hypothesized to be circumboreal, at least historically. As this was the sole resinicolous specimen found during 20 hours of searching by four lichenologists, it is clear more field surveys are required to document the range of calicioid species. Finally, based on public engagement through social media and a public lecture, with the purpose of arousing interest in these overlooked species, we propose the common name “Resin Whiskers” for this species.
Correlation between chronic disease management program (prolanis) activities and health status of hypertension patients at Muara Satu community health center, Lhokseumawe city

The Chronic Disease Management Program (Prolanis) is a program intended for people with chronic diseases such as hypertension which is quite effective but there are still many hypertensive patients who have not used the program. Hypertension is one of the causes of premature death due to the high rate of complications, the incidence of hypertension in the world continues to increase, especially in Indonesia. An increase in the incidence of hypertension will determine a person's health status. The purpose of this study was to identify the Chronic Disease Management Program (Prolanis), to identify the health status of Prolanis participants with hypertension, and to determine the relationship between Prolanis activities and the health status of hypertensive patients at the Muara Satu Subdistrict Health Center, Lhokseumawe City. The research method used a cross sectional research design, to analyze the relationship between Prolanis and the health status of hypertensive patients using the Chi Square test. The results showed the characteristics of the majority of Prolanis participants with hypertension were early elderly (46-55 years), female gender, not working, elementary school education, and marital status, as well as long suffering from hypertension with short duration occupying the highest position. The description of the degree of hypertension is more in the category of first-degree hypertension, most of the elderly who participate in Prolanis are in the good category (65.7%) and have the most health status in the good category (74.3%). The elderly who participate in Prolanis in the sufficient category will have sufficient health status (100%). Likewise, the elderly who participate in Prolanis in the good category will have a good health status (88.5). The conclusion of this study shows that there is a significant relationship between participating in Prolanis activities and the health status of the elderly.
Ultrasonographic evaluation of brain of newborn with hypoxic- ischaemic encephalopathy treated with anticonvulsant drug

Introduction: The most serious consequence of perinatal asphyxia is hypoxic-ischemic encephalopathy (HIE) which causes permanent damage to CNS tissues that may result in neonatal death or manifest later as cerebral palsy or developmental delay. Despite major advances in fetal and neonatal care, hypoxic ischemic encephalopathy
A Comparison of the Efficacy of Treatment With Fidaxomicin Versus Vancomycin in Clostridioides difficile Infection

Background Clostridioides difficile infection (CDI) is a major cause of diarrhea in hospitalized adult patients. This study aims to evaluate the clinical characteristics, clinical cure, recurrence and mortality in patients with CDI treated with either fidaxomicin or vancomycin. Methods A retrospective case-control study was conducted on patients with CDI treated with either fidaxomicin or vancomycin at a hospital from January 2019 to March 2022. Results We assessed 140 patients with CDI episodes, 70 patients treated with fidaxomicin and 70 with vancomycin. Seventy (50%) were male. Median age was 70 years old (IQR: 56-81). Fidaxomicin group had more recurrent CDI episodes within six months (59% vs 11%, p ≤ 0.001), more severity (43% vs 16%, p ≤ 0.001) and less treatment response (84% vs 100%, p ≤ 0.002) compared with vancomycin group. Recurrence and mortality rates in the follow-up period did not differ in both groups. Conclusions Our study found fidaxomicin treatment had worse outcomes due to restricted usage, potentially impacting its effectiveness in CDI. This finding is especially significant for patients with severe or recurrent CDI, as prescribing of the drug was limited until May 2022 in Spain with the lifting of this restriction, further research is necessary to better understand the potential benefits of fidaxomicin in treating CDI.
An image inpainting algorithm using exemplar matching and low-rank sparse prior

Image inpainting is a challenging problem with a wide range of applications such as object removal and old photo restoration. The methods based on low-rank sparse prior have been used for regular or nearly regular texture inpainting. However, since such inpainting results do not synthesize the original pixels, they are usually not sharp especially when the area to be recovered is large. One remedy is to use an exemplar-based method. However, it often produces false matches and cannot obtain globally consistent inpainting results. In this paper, we give a new model to promote low rankness and sparsity and solve this model with a recently proposed Riemannian optimization algorithm. Furthermore, we propose a novel two-stage algorithm by integrating the low-rank sparse model with an exemplar-based method. Numerical experiments demonstrate that the proposed low-rank sparsity-based method and the two-stage algorithm achieve encouraging results compared to state-of-the-art image completion algorithms.
The Prevalence of Neck and Back Pain among Paramedics in Poland

Neck Pain (NP) and low back pain (LBP) are ubiquitous musculoskeletal conditions and some of the major causes of disability worldwide. The aim of the study was to assess the incidence and risk factors of back pain among paramedics and their correlation with the nature of work, anthropometric features and the level of recreational physical activity. A group of 201 individuals (39 females (19.40%); 162 males (80.60%)), licensed to practice as paramedics in Poland completed a questionnaire containing the author’s interview as well as the Neck Disability Index (NDI) questionnaire and the Revised Oswestry Disability Index (ODI). Among the examined paramedics, 92% of the subjects reported the presence of back pain in different parts of the spine (36% C; 17% Th; and 85% LBP). The pain intensity, determined by VAS, was on average 4.26 (SD 1.77). The level of disability, assessed by NDI, was 7.67 (SD 5.73) on average, while the ODI was 7.51 (5.90). Work-related spinal strain has a major impact on the intensity and incidence of spinal pain. Spinal pain in paramedics mainly occurs in the lower back.
Restoration and Significance of the Original thickness of Triassic System in Baohaiwan Bay Basin

The tectonic evolution and paleogeothermic field in the Bohaiwan Basin were analyzed based on the modern oil and gas geological theories and using the new method of measuring vitrinite reflectance. Having analyzed the data from a number of boreholes in the Baohaiwan Basin using the EASY% R o numerical simulation, the author revealed the depositional framework of Triassic for the first time. The result shows that the development history of the huge depositional basin of Late Paleozoic in Huabei area lasted to the middle period of the Indosinian movement, and the embedding depth of Paleozoic source rocks is from 2500 m to 4000m. The embedding depth and space distribution of Paleozoic source rocks was mainly controlled by the original depositional thickness of Triassic system.
Individuals’ resistance to saving water: the cases of Argentina and Spain

Water management requires the participation of individuals who still seem to be reluctant to perform water-saving behaviours. Considering their country-specific water contexts, we analyse whether individuals’ water-saving behaviours depend on their resistance to change. Argentines and Spaniards ( n = 1068) participated in two online surveys conducted using two panels and individuals whom interviewers recruited. Both resistance to change and perceived risk positively and significantly affect individuals’ water-saving behaviours. By contrast, the country of origin does not moderate water-saving behaviours. We discuss these findings’ scholarly and water policy implications at the national and suprana-tional levels.
Salinity induced morpho-physiological characters and yield attributes in rice genotypes

The pot experiment was conducted at the glasshouse of University Putra Malaysia, Serdang, Selangor, Malaysia, during July to November 2012 to investigate the effect of different salinity levels on morpho-physiological characters, yield attributes and yield in five saline tolerant rice genotypes viz., SAL656, SAL614, SAL730, SAL613 and Pokkali. The four levels of sodium chloride induced salinity levels, 0, 6, 9 and 12 dSm -1 , were imposed at 25 days after planting. Results indicated that morpho-physiological characters such as plant height, tiller number, leaf number, root volume and weight, straw yield, harvest index, chlorophyll content, photosynthesis and stomatal conductance in leaves, yield attributes such as number of grains panicle -1 and 1000-grain weight, mineral ions in shoots, such as potassium and calcium, were decreased with gradual increasing of salinity levels while grain sterility and Na + content of shoot were increased with increasing soil salinity. The highest value of the above parameters was observed in control and the lowest values of them were observed at 12 dSm -1 . Generally genotypes having ability to exclude Na from shoot were found salt tolerant in respect of grain yield and vice versa. Among the genotypes, the yield loss due to salinity was less in SAL656 and Pokkali than that in the others, which further revealed that SAL656 and Pokkali had a greater tolerance to salinity than SAL614, SAL760 and SAL613. The rank of salinity tolerance was: PB SAL656 > Pokkali > PB SAL730 > PB SAL613 > PB SAL614.