Miracle-dz/UniFAR-FTUs huggingface dataset:
DESEMPENHO DE CULTIVARES DE GIRASSOL EM DUAS ÉPOCAS DE PLANTIO DE SAFRINHA NO PLANALTO NORTE CATARINENSE

In several Brazilian regions, the sunflower crop ( Helianthus annuus ) has been cultivated as a new economic alternative. The growth in the area planted with this crop is due to incentive of the National Program of Biodiesel. Thus, the objective of this work was to evaluate the grain yield and some agronomic characters in sunflower cultivars in two planting dates in “safrinha”. Two experiments were carried out in Papanduva, North Plateau of Santa Catarina State, Brazil. The experimental design used was the randomized blocks with three replicates. Were evaluated twelve sunflower genotypes in the first planting date (January) and 13 genotypes in the second planting date (February). Development cycle observed was between 93 to 107 days in function to the cultivar and planting date. In the second planting date, some cultivars showed high levels of lodging (until 29%) and plant breakage (until 42%). In the first planting date, 10,8% of the bagged flowers were infected by Sclerotinia sclerotiorum . In the second planting date, this level increased to 45%, affecting directly the grain yield, 1861 and 618 kg ha -1 , in the first and the second planting date, respectively.
LncRNA LINC01232 Enhances Proliferation, Angiogenesis, Migration and Invasion of Colon Adenocarcinoma Cells by Downregulating miR-181a-5p

LncRNAs play crucial roles in the progression of colon adenocarcinoma (COAD), but the role of LINC01232 in COAD has not received much attention. The present study was designed to explore the related mechanisms of LINC01232 in the progression of COAD. LINC01232, miR-181a-5p, p53, c-myc, Bcl-2, cyclin D1, p16, Bax, VEGF, E-cadherin, vimentin, N-cadherin and SDAD1 expressions were determined by western blot and qRT-PCR. CCK-8, tubule formation, and Transwell assays were employed to detect proliferation, angiogenesis, and migration/invasion of COAD cells, respectively. The relationship between LINC01232 and miR-181a-5p was predicted by LncBase Predicted v.2, and then verified through dual luciferase reporter gene assay. According to the results, LINC01232 was highly expressed in COAD cells and enhanced proliferation, angiogenesis, migration, and invasion of COAD cells. Downregulated LINC01232 promoted expression of p53 and p16, and inhibited c-myc, Bcl-2 and cyclin D1 expressions in COAD cells, while upregulation of LINC01232 generated the opposite effects. LINC01232 was negatively correlated with miR-181a-5p while downregulated miR-181a-5p could reverse the effects of siLINC01232 on cell proliferation, angiogenesis, migration, and invasion. Similarly, miR-181a-5p mimic could also offset the effect of LINC01232 overexpression. SiLINC01232 increased the expressions of Bax and E-cadherin, and decreased the expressions of VEGF, vimentin, N-cadherin and SDAD1, which were partially attenuated by miR-181a-5p inhibitor. Collectively, LINC01232 enhances the proliferation, migration, invasion, and angiogenesis of COAD cells by decreasing miR-181a-5p expression.
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance

Poly‐ADP‐ribose polymerase (PARP) inhibitors (PARPi) have shown great promise for treating BRCA‐deficient tumors. However, over 40% of BRCA‐deficient patients fail to respond to PARPi. Here, we report that thioparib, a next‐generation PARPi with high affinity against multiple PARPs, including PARP1, PARP2, and PARP7, displays high antitumor activities against PARPi‐sensitive and ‐resistant cells with homologous recombination (HR) deficiency both in vitro and in vivo. Thioparib treatment elicited PARP1‐dependent DNA damage and replication stress, causing S‐phase arrest and apoptosis. Conversely, thioparib strongly inhibited HR‐mediated DNA repair while increasing RAD51 foci formation. Notably, the on‐target inhibition of PARP7 by thioparib‐activated STING/TBK1‐dependent phosphorylation of STAT1, triggered a strong induction of type I interferons (IFNs), and resulted in tumor growth retardation in an immunocompetent mouse model. However, the inhibitory effect of thioparib on tumor growth was more pronounced in PARP1 knockout mice, suggesting that a specific PARP7 inhibitor, rather than a pan inhibitor such as thioparib, would be more relevant for clinical applications. Finally, genome‐scale CRISPR screening identified PARP1 and MCRS1 as genes capable of modulating thioparib sensitivity. Taken together, thioparib, a next‐generation PARPi acting on both DNA damage response and antitumor immunity, serves as a therapeutic potential for treating hyperactive HR tumors, including those resistant to earlier‐generation PARPi.
Mean-field calculation of compressed finite nuclei with {Delta} excitations

The energies and matter densities of finite nuclei under radial compression are predicted by using a constrained Hartree-Fock method with the {Delta} degree of freedom included. The results are presented for {sup 90}Zr in a calculation within a model space of seven major oscillator shells. The main feature of this calculation is that the effective baryon-baryon interactions associated with the {Delta} are evaluated within a G-matrix approach based on a coupled-channel NN{circle_plus}N{Delta}{circle_plus}{pi}NN model that can describe the NN data up to 1 GeV. It is found that as the nucleus is compressed to about 2{endash}3 times of the ordinary nuclear density, the {Delta} component is sharply increased to about 10{percent} of all baryons in the system. This result is consistent with the values extracted from relativistic heavy-ion collisions. {copyright} {ital 1997} {ital The American Physical Society}
Coupled-Mode Theory for Optical Fibers

A set of coupled-mode equations is derived to describe mode propagation in uniform and slightly nonuniform cylindrical optical-fiber systems. The coupling between fibers of an array made up of n identical fibers each at the vertex of a polygon and one at the center, which is not necessarily the same as its n neighbors, is determined. Examples of this array are two fibers, three fibers in a row, and a hexagonal array with a fiber in the center. Very simple expressions for the coupling coefficients are presented. Mode coupling on a lossy fiber is investigated and a simple expression for the loss of a HE11 mode is given.
Clinical Nurse Specialist Tracheostomy Management Improves Patient Outcomes

Background: Patients with a tracheostomy are a low-volume, high-risk population with long lengths of hospital stay and high health care costs. Problem: Because of the complex nature of caring for patients with a tracheostomy, it is essential to provide a standardized care approach with ongoing monitoring to optimize outcomes. Approach: A pre/postimplementation design was used. A formal tracheostomy care management process using clinical nurse specialists (CNSs) was implemented. Outcomes: Between April 2019 and December 2020, this process resulted in a significant reduction in time between tracheostomy placement and discharge, from 16 to 12.9 days (P = .02). Reductions were also seen in length of stay and incidence of tracheostomy-related pressure injuries. Conclusions: This project shows that a CNS-led care management process can improve patient outcomes. These improvements in patient outcomes resulted in a significant cost savings to the organization.
An Analysis of Prehospital Pediatric Medication Dosing Errors after Implementation of a State-Wide EMS Pediatric Drug Dosing Reference

Abstract Background Medication dosing errors are common in prehospital pediatric patients. Prior work has shown the overall medication error rate by emergency medical services (EMS) in Michigan was 34.7%. To reduce these errors, the state of Michigan implemented a pediatric dosing reference in 2014 listing medication doses and volume to be administered. Objective To examine changes in pediatric dosing errors by EMS in Michigan after implementation of the pediatric dosing reference. Methods We conducted a retrospective review of the Michigan Emergency Medical Services Information System of children ≤ 12 years of age from June 2016–May 2017 treated by 16 EMS agencies. Agencies were a mix of public, private, third-service, and fire-based. A dosing error was defined as >20% deviation from the weight-appropriate dose listed on the pediatric dosing reference. Descriptive statistics with confidence intervals and standard deviations are reported. Results During the study period, there were 9,247 pediatric encounters, of whom 727 (7.9%) received medications and are included in the study. There were 1078 medication administrations, with 380 dosing errors (35.2% [95% CI 25.3–48.4]). The highest error rates were for dextrose 50% (3/4 or 75% [95% CI 32.57–100.0]) and glucagon (3/4 or 75% [95% CI 32.57–100.0]). The next highest proportions of incorrect doses were opioids: intranasal fentanyl (11/16 or 68.8% [95% CI 46.04–91.46]) and intravenous fentanyl (89/130 or 68.5% [95% CI 60.47–76.45]). Morphine had a much lower error rate (24/51 or 47.1% [95% CI 33.36–60.76]). Midazolam had the third highest error rate, for intravenous (27/50 or 54.0% [95% CI (40.19–67.81]) and intramuscular (25/68 or 36.8% [95% CI 40.19–67.81]) routes. Epinephrine 1 mg/10 ml had an incorrect dosage rate of 35/119 (29.4% [95% CI 20.64–36.99]). Asthma medications had the lowest rate of incorrect dosing (albuterol sulfate 9/247 or 3.6% [95% CI 1.31–5.98]). Conclusions Medications administered to prehospital pediatric patients continue to demonstrate dosing errors despite pediatric dosing reference implementation. Although there have been improvements in error rates in asthma medications, the overall error rate has increased. Continued work to build patient safety strategies to reduce pediatric medication dosing errors by EMS is needed.
Narrow-band, tunable infrared emission from arrays of microstrip patches

We demonstrate through a combination of theory and experiment that an array of microstrip patches leads to a surface with sharp and tunable emission bands. The physical mechanisms and locations for various emission peaks are described via both analytical theory and numerical simulations. These predictions agree well with our experimental data, taken on systems designed to emit strongly in the infrared. The main peak, which arises from plasmons trapped under a patch, can be well separated from other spectral structures, narrow in wavelength, but broad in angular distribution.
Middle Ear Teratoma: Clinical and Imaging Features

Background Teratoma is a true neoplasm composed of a number of different types of tissue derived from the three germinal layers but rarely occurs in the middle ear (ME). The features of middle ear teratomas (MET) have not been well described. Objective The objective of this study is to explore the clinical and imaging features of MET, and report 2 rare cases of MET with ear malformation that have never been reported. Materials and Methods The clinical, CT and MRI data of 8 patients with a pathological diagnosis of MET were collected and retrospectively mined, and 14 patients with MET reported in previous literature were also reviewed. Results ① Female, left ear predominance in MET, and the most common symptoms were otorrhea and hearing loss. ② On CT and MRI, the MET presented as an irregular soft tissue mass that was heterogeneous, with fatty tissue and involved multiple sites, and the ET and tympanum were correspondingly expanded and locally destroyed. ③ Mictotia with MET in two patients was presented, which was the first report. Conclusion MET has female sex and left ear predominance. CT and MRI can be used to diagnose MET and display its extent and its relationship to the carotid canal in detail. Complete surgical excision is the definitive treatment.
Weighted Lebesgue and Lorentz norm inequalities for the Hardy operator

Characterizations are obtained for those pairs of weight functions w, v for which the Hardy operator Tf(x) J fo f(s) ds is bounded from the Lorentz space L'"s((0, oo), v dx) to LP, ((O, oo), w dx), 0 < p, q, r, s - oo. The modified Hardy operators T,f(x) = x-17Tf(x) for q real are also treated. 1. Introduction. We characterize weighted Lebesgue and Lorentz norm inequalities for the Hardy operator Tf(x) = fox f(t) dt and the modified Hardy operators T1 f(x)
Word-association norms for 1,100 French words with varying levels of concreteness

The organisation of concepts in the mental lexicon is a widely studied research topic in experimental psychology. For instance, several studies have shown that whereas concrete concepts are organised according to semantic similarity, abstract concepts are organised according to verbal association. However, these results are not systematically replicated, mainly due to a lack of normative database especially in French. To that end, we introduce a French word-association database for 1,100 cues with varying levels of concreteness from abstract to concrete concepts. Analyses from the word-association task revealed stronger association strength for concrete concepts compared with abstract concepts. Additional results showed that cues tend to elicit responses of a similar level of concreteness. The database will be useful for investigators interested in French verbal associations for abstract and concrete concepts. The data (available on OSF https://osf.io/dhuqs/) introduce responses organised according to association strength and provides cue concreteness.
Home Modifications for Older Adults: A Systematic Review

While ≧10,000 Americans turn 65 years old every day, only 10% of American homes are “aging ready. ” Unsafe homes can exacerbate disability, lead to falls, and increase the likelihood of hospitalization. With increased investments in home and community-based services, public health stakeholders are considering home modifications to promote successful aging. While several home modification models exist, there is significant heterogeneity between models and no consensus on critical features. PubMed, EMBASE, and Web of Science were reviewed and twelve randomized controlled trials of home modifications for older adults were identified and evaluated for model structure, reported outcomes, and risk of bias. Overall, occupational therapist-driven home modifications supplemented with clinical, physical activity, and/or behavioral components saw the greatest success. This systematic review discusses the components of these models, highlights particularly effective and frequently used features, and the practice and research needed to create effective next-generation home modification models which promote healthy longevity.
No Correlation Between Mood or Motivation and the Processing of Global and Local Information

Abstract. Mood has been argued to impact the breadth of human attention, but the empirical evidence supporting this claim remains shaky. Gable and Harmon-Jones (2008) have attributed previous empirical inconsistencies regarding the effect of mood on attentional breath to a critical role of approach/avoidance motivation. They demonstrated that the combination of positive affect with high, but not with low, motivational intensity improves performance during processing local information and impairs performance during processing global information. The latter, but not the former, was replicated by Domachowska et al. (2016). Since we were interested in the modulation of attention by valence and motivation, and considering the inconsistencies in the findings, we replicated the critical experiments of both studies in four online experiments but found no significant effect of either valence or motivational intensity on attention. Taken together, our evidence casts doubt on a systematic relationship between mood or motivation on the one hand and global/local processing on the other.
The impact of the COVID-19 pandemic on in-hospital mortality in patients admitted through the emergency department

Objective The COVID-19 pandemic might have adversely affected outcomes of patients in emergency departments (EDs). The aim of this study is to evaluate the impact of the COVID-19 pandemic on in patients admitted through the emergency department. Methods This study is a single-center, retrospective, observational cohort study. We compared the prognosis of patients admitted through the ED before the COVID-19 pandemic (November 2018 to June 2019) and after COVID-19 (November 2020 to June 2021). The primary outcome was in-hospital mortality. Multivariable logistic regression analysis was performed to determine whether the COVID-19 pandemic was independently associated with patient prognosis. Results The number of patients admitted through the ED before and after COVID-19 was 5,333 and 4,625, respectively. The mean ED length of stay before and after COVID-19 was 401 and 442 minutes, respectively (P<0.001). The number of in-hospital deaths before and after COVID-19 were 269 (5.0%) and 322 (7.0%), respectively (P<0.001). Multivariable logistic regression analysis showed that the COVID-19 period was significantly associated with higher in-hospital mortality (adjusted odds ratio, 1.37; 95% confidence interval, 1.12–1.67; P=0.002). Conclusion In the COVID-19 period, in-hospital mortality increased compared to that before COVID-19 among hospitalized ED patients.
Aridity‐dependent sequence of water potentials for stomatal closure and hydraulic dysfunctions in woody plants

The sequence of physiological events during drought strongly impacts plants' overall performance. Here, we synthesized the global data of stomatal and hydraulic traits in leaves and stems of 202 woody species to evaluate variations in the water potentials for key physiological events and their sequence along the climatic gradient. We found that the seasonal minimum water potential, turgor loss point, stomatal closure point, and leaf and stem xylem vulnerability to embolism were intercorrelated and decreased with aridity, indicating that water stress drives trait co‐selection. In xeric regions, the seasonal minimum water potential occurred at lower water potential than turgor loss point, and the subsequent stomatal closure delayed embolism formation. In mesic regions, however, the seasonal minimum water potential did not pose a threat to the physiological functions, and stomatal closure occurred even at slightly more negative water potential than embolism. Our study demonstrates that the sequence of water potentials for physiological dysfunctions of woody plants varies with aridity, that is, xeric species adopt a more conservative sequence to prevent severe tissue damage through tighter stomatal regulation (isohydric strategy) and higher embolism resistance, while mesic species adopt a riskier sequence via looser stomatal regulation (anisohydric strategy) to maximize carbon uptake at the cost of hydraulic safety. Integrating both aridity‐dependent sequence of water potentials for physiological dysfunctions and gap between these key traits into the hydraulic framework of process‐based vegetation models would improve the prediction of woody plants' responses to drought under global climate change.
Genetic Landscape of Major Depressive Disorder: Assessment of Potential Diagnostic and Antidepressant Response Markers

Abstract Background The clinical heterogeneity in major depressive disorder (MDD), variable treatment response, and conflicting findings limit the ability of genomics toward the discovery of evidence-based diagnosis and treatment regimen. This study attempts to curate all genetic association findings to evaluate potential variants for clinical translation. Methods We systematically reviewed all candidates and genome-wide association studies for both MDD susceptibility and antidepressant response, independently, using MEDLINE, particularly to identify replicated findings. These variants were evaluated for functional consequences using different in silico tools and further estimated their diagnostic predictability by calculating positive predictive values. Results A total of 217 significantly associated studies comprising 1200 variants across 545 genes and 128 studies including 921 variants across 412 genes were included with MDD susceptibility and antidepressant response, respectively. Although the majority of associations were confirmed by a single study, we identified 31 and 18 replicated variants (in at least 2 studies) for MDD and antidepressant response. Functional annotation of these 31 variants predicted 20% coding variants as deleterious/damaging and 80.6% variants with regulatory effect. Similarly, the response-related 18 variants revealed 25% coding variant as damaging and 88.2% with substantial regulatory potential. Finally, we could calculate the diagnostic predictability of 19 and 5 variants whose positive predictive values ranges from 0.49 to 0.66 for MDD and 0.36 to 0.66 for response. Conclusions The replicated variants presented in our data are promising for disease diagnosis and improved response outcomes. Although these quantitative assessment measures are solely directive of available observational evidence, robust homogenous validation studies are required to strengthen these variants for molecular diagnostic application.
Obstetric, neonatal, and child health outcomes following embryo biopsy for preimplantation genetic testing

Abstract BACKGROUND Preimplantation genetic testing (PGT) of embryos developed in vitro requires a biopsy for obtaining cellular samples for the analysis. Signs of cell injury have been described in association with this procedure. Thus, the consequences of the biopsy on obstetric and neonatal outcomes have been the subject of some quantitative analyses, although the reliability of data pooling may be limited by important issues in the various reports. OBJECTIVE AND RATIONALE The present review identifies evidence for whether pregnancies conceived after embryo biopsy are associated with a higher risk of adverse obstetric, neonatal, and long-term outcomes. Available evidence has been summarized considering manipulation at various stages of embryo development. SEARCH METHODS We used the scoping review methodology. Searches of article databases were performed with keywords pertaining to the embryo biopsy technique and obstetric, neonatal, and postnatal outcomes. Studies in which embryos were biopsied at different stages (i.e. both at the cleavage and blastocyst stages) were excluded. We included data on fresh and frozen embryo transfers. The final sample of 31 documents was subjected to qualitative thematic analysis. OUTCOMES Sound evidence is lacking to fully address the issues on the potential obstetric, neonatal or long-term consequences of embryo biopsy. For polar body biopsy, the literature is too scant to draw any conclusion. Some data, although limited and controversial, suggest a possible association of embryo biopsy at the cleavage stage with an increased risk of low birthweight and small for gestational age neonates compared to babies derived from non-biopsied embryos. An increase in preterm deliveries and birth defects in cases of trophectoderm biopsy was suggested. For both biopsy methods (at the cleavage and blastocyst stages), an increased risk for hypertensive disorders of pregnancy was found. However, these findings may be explained by confounders such as other embryo manipulation procedures or by intrinsic patient or population characteristics. WIDER IMPLICATIONS Since there is inadequate evidence to assess obstetric, neonatal, and long-term health outcomes following embryo biopsy, an invasive PGT strategy should be developed with a cautious approach. A non-invasive approach, based on the analysis of embryo cell-free DNA, needs to be pursued to overcome the potential limitations of embryo biopsy.