Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychosocial Determinants of Changes in Dietary Behaviors Among Iranian Women: An Application of the Pender’s Health Promotion Model

Data on how the complex cognitive processes, personal, and social factors influence health promoting behaviors of women are very limited and the results have been inconsistent. Here, we examine how prior behaviors, behavior-specific cognition (perceived benefits/barriers, self efficacy, and activity-related affect), situational and interpersonal factors (social support, modeling, and norms) associated with the level of dietary behaviors in Iranian women. A cross sectional survey of 356 women aged 18–60 years from health care centers in Iran was undertaken from October 2015 to September 2016. Multiple analytical models and Pender’s health promotion model (HPM) were implemented to examine the effectiveness of HPM and its potential constructs on PA behaviors. The instruments used were designed using Pender’s HPM as a basis. The path model fitted data and accounted for 51% of the variance in dietary behaviors; and prior behavior, perceived self-efficacy, interpersonal influences, and commitment to plan were significantly associated with dietary behavior. We found that constructs from the HPM are empirically improved dietary behavior among the women population. This result provides a suitable source for designing strategies of a nutrition education intervention for improving the frequency and nutrient intake of breakfast consumption among female students.
Mental health matters: A cross-sectional study of mental health nurses' health-related quality of life and work-related stressors.

Mental health nursing is widely recognized as a stressful occupation; however, little is known about the relationship between work-related stress and health-related quality of life of mental health nurses (MHN). This study aimed to identify MHN health-related quality of life (HR-QoL) and work-related stressors; associations between stressors and HR-QoL; and predictors of HR-QoL. An online cross-sectional survey collected demographic data, work-related stressors and HR-QoL (SF-12v2) of n = 498 Australian MHN. Prominent consumer/carer-related stressors were verbal (90%) and physical aggression (85%). Collegial stressors included staff conflict (71%) and bullying (55%), and colleague-perpetrated verbal (34%) and physical aggression (7%). Key organizational stressors included high workloads (74%), lack of organizational support (60%) and lack of adequate resources to perform nursing role (58%). The mean physical health score was 52.62 (SD = 8.30), and mental health score was 43.59 (SD = 11.34), with mental health substantially lower than national norms (mean difference = 10.11). There were statistically significant negative correlations between the number of work-related stressors and HR-QoL. Younger (21-30 years) and less experienced (<1-4 years) MHN had substantially lower mental health. Higher mental health was predicted with < 15 stressors, >4 years' experience and working in the community. The poorer mental health of MHN has concerning implications for the well-being, retention and practice of the largest group in the mental health workforce. There is a critical need for organizations to enact effective policy and initiatives to reduce workplace aggression, improve staff psychological and physical safety, and strengthen well-being and resilience. New graduates are a priority group for urgent intervention.
Politics, Personality, and Impulsivity Can Color People’s Perceptions of—and Responses to—Hurricane Threats of Varying Severity

Theory and research suggest that objective features of a threatening situation and individual differences influence threat responses. We examine three ways individual traits may relate to a threat response: (a) directly and independent of objective threat features, (b) indirectly through relationships with threat perception, or (c) as moderators of the relationship between objective threat features and responses. Using integrative data analysis (IDA), we aggregated data across three studies examining hurricane preparation intentions. Analysis supported two of the potential pathways. Supporting the first path, both openness and extraversion had direct, positive relationships with preparation likelihood. Supporting the second path, agreeableness, conscientiousness, and social conservatism positively related to preparation likelihood through a positive relationship with threat perception, whereas impulsivity and sensation-seeking negatively related to preparation likelihood through a negative relationship with threat perception. This work shows the pivotal role individual differences play regarding responses to uncertain threats.
Effects of different phosphorus concentrations on growth and biochemical composition of Desmodesmus communis (E.Hegewald) E.Hegewald

Abstract The members of the family Scenedesmaceae has the most widely used microalgae species in algal biotechnology studies because of their fast growth rate, quality of nutrition content and lipid accumulation under nutrient-limiting conditions. However, the biochemical responses of the species under phosphorus (P) limiting conditions are still unknown. The growth and biochemical composition of Desmodesmus communis in response to different phosphorus concentrations were investigated in this research. Five different phosphorus conditions were used: control (BG11); excess treatments (50% P+, 75% P+) and limited treatments (50% P−, 75% P-The highest cell concentration was observed in 75% P+ (725.6 × 104 cells/mL), whereas the highest dry weight concentration (1.81 mg/L) was found in 50% P- medium. The highest total lipid (4.94%) accumulation was found in the 50% P + medium and the maximum protein (49.5%) content was detected in 50% P- medium. Fatty acid and amino acid compositions change according to P concentration. PUFAs concentrations are higher than SFAs and MUFAs. Therefore the microalgae biomass obtained from this study cannot be used for biodiesel production although it is more suitable for nutritional supplement productions.
Topical preservative-free ophthalmic treatments: an unmet clinical need

ABSTRACT Introduction: The main role of preservatives in eyedrops is to ensure sterility and microbiological integrity of the drug, and to facilitate the penetration of active compounds into the eye. However, several studies documented significant toxic effects induced by preservatives, especially on the ocular surface. Consequently, most of the ophthalmic medications became progressively available in preservative-free (PF) formulations. Areas covered: We analyzed pre-clinical and clinical studies on PF eyedrops with particular attention to common chronic diseases such as dry eye and glaucoma. We discussed about the pros and cons of using PF eyedrops, in terms of efficacy, safety, and social-economic aspects. Expert opinion: There are still unresolved issues that make hard for PF medications to definitively conquer the drug market. Despite robust pre-clinical evidences of less toxicity, the low number of randomized clinical trials does not permit to state that PF eyedrops have, in clinical practice, a similar efficacy or a higher safety compared to preserved forms. These aspects limit their use to chronic diseases requiring long-term therapies with multiple daily instillations, especially in the presence of concomitant ophthalmic diseases that expose to a risk of ocular surface worsening.
Antinociceptive and Anti-inflammatory like effects of Berberis baluchistanica.

BACKGROUND Numerous therapeutic agents are in clinical practice for the treatment of inflammatory and painful conditions, but their applications has been challenged by various side /toxic effects. Therefore, new effective and safe therapies are most warrant, for which medicinal plant could be a significant alternative. Berberis baluchistanica has traditionally been used as analgesic and antiinflammatory without any scientific background. OBJECTIVE The current study was designed to evaluate the analgesic and antiinflammatory like effects of extract B. baluchistanica in animal models. METHODS For the study of antinociceptive effect, an of extract of B. baluchistanica (100, 200 and 300 mg/kg i.p.), were tested in acetic acid induced writhing and formalin tests. while for the antiinflammatory action, carrageenan induced paw edema, cotton pellet induced granuloma and xylene induced ear edema tests were used. RESULTS The results showed significant dose dependent antinociceptive effect of extract of B. baluchistanica in acetic acid induced writhing and formalin induced flinching behavior tests. However, the effect was strongly antagonized by the injection of naloxone, suggesting the expression via opioidergic receptors. Similarly, strong antiinflammatory action was illustrated in carrageenan induced paw edema, cotton pellet induced granuloma and xylene induced ear edema tests and thus provided evidence for the versatile phytochemical nature of its phytochemical. CONCLUSIONS In short, it is concluded that the extract of B. baluchistanica exhibited significant antinociceptive and antiinflammatory effects in animal models. It is, therefore, further detail studies on the efficacy and safety as well as on the phytochemical investigation are required to ascertain its clinical uses.
Fruit Yield of Tomato Cultivated on Media with Bicarbonate and Nitrate/Ammonium as the Nitrogen Source

ABSTRACT This article presents the effects of nitrate/ammonium (NO3 −/NH4 +), applied at different proportions to the root media with or without 5 mmol bicarbonate (HCO3 −), on the yield and chemical composition of tomato fruit. Tomato plants were grown hydroponically (pH 6.9) in glasshouse conditions. The yield of fruit fresh matter from four clusters obtained from plants grown on the medium with NH4 + was about 25% lower than from the plants grown on the medium containing NO3 − as the nitrogen (N) source. Supplying NO3 −/NH4 + at a ratio of 4:1 increased the fruit yield by about 20% in comparison with the value recorded for NO3 −−plants. The enrichment of the medium with HCO3 − stimulated the bearing, while the result depended on the ratio of NO3 −/NH4 +. A combined treatment of HCO3 − with NO3 − or NH4 + in the medium increased yields by about 28% and 11%, respectively, in comparison to plants cultivated without HCO3 −. The application of NO3 −/NH4 + at ratios of 4:1 and 1:1 with HCO3 − increased the respective yields by about 16% and 10% in comparison with plants grown without HCO3 −. Modifications in the composition of the media affected the accumulation of organic solutions in the fruit. The NH4 + nutrition effected a 20% decrease in the accumulation of reducing sugars in the fruit in comparison to the fruit of plants grown in media with NO3 −. In the cultivation of plants in media with various NO3 −/NH4 + proportions the intermediate values of the reduced sugar concentrations were recorded in comparison with the values obtained for NO3 −−plants and NH4 +−plants. The enrichment of media with HCO3 − increased the concentration of sugars in fruit from about 28% (for NO3 −−plants) to about 10% (for NH4 +−plants). Malate and citrate are the main constituents of carboxylates in tomato fruit. The form of nitrogen applied to the medium did not significantly affect the concentration of carboxylates in fruit. Significant differences in carboxylate concentrations appeared in fruit grown on media enriched with HCO3 − ions. In comparison with the cultivation without HCO3 −, increases in the accumulation of carboxylates varied from about 22% to 30% depending on the form of the applied nitrogen. The concentration of amino acids in the fruit of plants grown with NH4 + exceeded that in NO3 −−plants by about 55%. In the plants grown on media of modified NO3 −/NH4 + proportions, the concentration of amino acids in fruits were positively correlated with the level of NH4 + in the medium. The enrichment of media with HCO3 − stimulated a further increase in amino acid concentration in fruit by about 9% in NO3 − plants and about 21% in NH4 + plants compared with the respective control (without HCO3 −).
Feline Pituitary Adenomas: Correlation of Histologic and Immunohistochemical Characteristics With Clinical Findings and Case Outcome

Pituitary glands from 141 feline autopsy cases were reviewed histologically. Adenoma and hyperplasia were the most common lesions at 13 cases each. Pituitary adenoma was more likely than hyperplasia to be associated with clinical evidence of endocrinopathy or an intracranial mass (P < .001). A histochemical and immunohistochemical panel was applied to 44 autopsy- or hypophysectomy-derived pituitary adenomas in 43 cats from 2 diagnostic laboratories. Adenomas were differentiated from hyperplasia by the presence of disrupted reticulin fibers. One cat had a double (somatotroph and melanotroph) adenoma. Twenty somatotroph adenomas consisted of periodic acid-Schiff (PAS)-negative acidophils that expressed growth hormone; 16/20 had hypersomatotropism; 17/20 had diabetes mellitus. Eleven melanotroph adenomas consisted of PAS-positive basophils or chromophobes that expressed melanocyte-stimulating and adrenocorticotrophic hormones; 5/11 had hypercortisolism; 6/11 had diabetes mellitus. Eleven gonadotroph adenomas consisted of PAS-negative chromophobes that expressed follicle-stimulating and/or luteinizing hormones. Two thyrotroph adenomas consisted of PAS-negative basophils or chromophobes that expressed thyroid-stimulating hormone. Pituitary-dependent disease was not recognized in cats with gonadotroph or thyrotroph adenomas. The Ki-67 proliferation index in hypophysectomy specimens was lower in somatotroph than in melanotroph adenomas. Fourteen cats with hypophysectomy-treated somatotroph or melanotroph adenoma had an 899-day median survival time versus 173 days in 17 nonsurgical cases. After adjusting for age, adenoma size and type, hypophysectomized cats had an overall better survival time than nonsurgical cases (P = .029). The study results underscore the value of hypophysectomy and trophic hormone immunohistochemistry in the treatment and classification of feline pituitary adenomas.
A systematic review and thematic synthesis of qualitative studies exploring GPs' and nurses' perspectives on discussing weight with patients with overweight and obesity in primary care

Guidelines and evidence suggest primary care clinicians should give opportunistic interventions to motivate weight loss, but these rarely occur in practice. We sought to examine why by systematically reviewing qualitative research examining general practitioners' (‘GPs’) and nurses' views of discussing weight with patients. We systematically searched English language publications (1945‐2018) to identify qualitative interview and focus group studies. Thematic methods were used to synthesise the findings from these papers. We synthesised the studies by identifying second‐order themes (explanations offered by the original researchers) and third‐order constructs (new explanations which went beyond those in the original publications). Quality assessment using the Joanna Briggs checklist was undertaken. We identified 29 studies (>601 GPs, nurses and GP trainees) reporting views on discussing weight with patients. Key second‐order themes were lack of confidence in treatments and patients' ability to make changes, stigma, interactional difficulty of discussing the topic and a belief of a wider societal responsibility needed to deal with patients with overweight and obesity. The third‐order analytical theme was that discussions about weight were not a priority, and other behavioural interventions, including those relating to smoking, often took precedent. GPs and nurses reported that noting body mass index measurements at every consultation alongside a framework to deliver interventions would likely increase the frequency and perceived efficacy of behavioural weight interventions. GPs and nurses acknowledge the importance of obesity as a health issue, but this is insufficient, particularly amongst GPs, for them to construe this as a medical problem to address with patients in consultations. Strategies to implement clinical guidelines need to make tackling obesity a clinical priority. Training to overcome interactional difficulties, regular weighing of patients and changing expectations and understanding of weight loss interventions are also probably required.
The Lung Adenocarcinoma Microenvironment Mining and Its Prognostic Merit

Background: As a common pathological type of lung cancer, lung adenocarcinoma (LUAD) is mainly treated by surgery, chemotherapy, targeted therapy and radiotherapy. Although a relatively mature treatment system has been established, there are few studies on the microenvironment of LUAD. Material and Methods: The immune and stromal scores of patients from the LUAD cohort in the TCGA database were obtained by using ESTIMATE. The relationship of immune and stromal scores with the clinicopathological characteristics and overall survival of LUAD patients was assessed by R. GO, KEGG and Cox regression analyses were employed to analyze intersecting genes and to identify reliable prognostic markers. The identified genes were also analyzed in the GEPIA database to assess their correlations with survival, and these relationships were verified with the Kaplan-Meier Plotter database. Results: The immune score was related to the survival time and tumor topography of LUAD patients. There was a significant correlation between stromal score and tumor metastasis. Through multivariate analysis, stage (HR = 1.640, 95% CI = 1.019-2.642, P = 0.042) and risk score (HR = 1.036, 95% CI = 1.026-1.046, P < 0.001). The genes (ARHGAP15, BTLA, CASS4, CLECL1, FAM129C, STAP1, TESPA1, and S100P) showed credible prognostic value in LUAD patients in TCGA through GEPIA database online analysis and verification in the Kaplan-Meier plotter database. Conclusions: In the microenvironment of lung adenocarcinoma, the differentially expressed genes screened by immune score and stromal score have certain value in evaluating the survival/prognosis of patients, as well as the invasion and progression of tumors.
Evaluation of Rooming-in Practice for Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Italy.

Importance The management of mother-infant dyads during the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic constitutes a major issue for neonatologists. In mothers with SARS-CoV-2 infection, current recommendations suggest either to separate the dyad or encourage protected rooming-in under appropriate precautions. No data are available regarding the risk of mother-to-infant transmission of SARS-CoV-2 during rooming-in. Objective To evaluate the risk of postnatal transmission of SARS-CoV-2 from infected mothers to their neonates following rooming-in and breastfeeding. Design, Setting, and Participants A prospective, multicenter study enrolling mother-infant dyads from March 19 to May 2, 2020, followed up for 20 days of life (range, 18-22 days), was performed. The study was conducted at 6 coronavirus disease 2019 maternity centers in Lombardy, Northern Italy. Participants included 62 neonates born to 61 mothers with SARS-CoV-2 infection who were eligible for rooming-in practice based on the clinical condition of the mother and infants whose results of nasopharyngeal swabs were negative at birth. Exposures Mothers with SARS-CoV-2 infection were encouraged to practice rooming-in and breastfeeding under a standardized protocol to minimize the risk of viral transmission. Main Outcomes and Measures Clinical characteristics and real-time reverse transcriptase-polymerase chain reaction for SARS-CoV-2 on neonatal nasopharyngeal swabs at 0, 7, and 20 days of life. Results Of the 62 neonates enrolled (25 boys), born to 61 mothers (median age, 32 years; interquartile range, 28-36 years), only 1 infant (1.6%; 95% CI, 0%-8.7%) was diagnosed as having SARS-CoV-2 infection at postbirth checks. In that case, rooming-in was interrupted on day 5 of life because of severe worsening of the mother's clinical condition. The neonate became positive for the virus on day 7 of life and developed transient mild dyspnea. Ninety-five percent of the neonates enrolled were breastfed. Conclusions and Relevance The findings of this cohort study provide evidence-based information on the management of mother-infant dyads in case of SARS-CoV-2 maternal infection suggesting that rooming-in and breastfeeding can be practiced in women who are able to care for their infants.
Prevalence and Risk Factors Associated With Physical and/or Sexual Abuse Among Female Middle School Students: A Cross- Sectional Study in Kinshasa, DRC

This cross-sectional study sought to broaden the limited evidence on violence against young adolescent girls in non-conflict zones within the Democratic Republic of the Congo (DRC). Our goal was to estimate the prevalence of and the predictors of physical and/or sexual abuse among girls aged 11–18 years in Kinshasa. A total of 3,100 girls from five randomly selected schools were recruited by our team and given the questionnaires; among them, 3,011 (97.1%) participants completed the questionnaires and were included in the study for further analysis. After collecting all valid responses, the overall prevalence of physical and/or sexual abuse was sorted into the following categories: experienced physical abuse without a weapon (recorded by 70.1% of respondents), experienced physical abuse with a weapon (66.3% of respondents), attempted rape without penetration (76.5% of respondents), experienced attempted rape with penetration (73.9% of respondents), and experienced verbal sexual harassment (93.0%). Our logistic regression analysis indicated that specific kinds of living arrangements (such as only living with the father, mother, or a caregiver; odds ratio ranged 1.8 to 6.9) and places of residence (such as living in lower-class or middle-class districts; odds ratio ranged 1.7 to 6.2) had the strongest associations with higher risk pertaining to whether the respondent had experienced physical and/or sexual abuse in the past. Meanwhile, factors such as the students’ level of education (both middle grade and upper grade) and occupation of the father (specifically whether holding a part-time job or retired) were deemed to be more protective. However, physical and/or sexual abuse prevalence was found to be high among middle school girls in Kinshasa. Therefore, we recommend that drastic policies and strategies aimed at socioeconomic issue and living condition ameliorations among families should be implemented to curtail physical and sexual abuse in the nonconflict zones of the DRC.