Miracle-dz/UniFAR-FTUs huggingface dataset:
920: FIXED- VERSUS VARIABLE-DOSE PROTHROMBIN COMPLEX CONCENTRATE FOR WARFARIN-ASSOCIATED MAJOR HEMORRHAGE

Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal. org Learning Objectives: An opioid epidemic has significantly affected the United States over the past several decades; both the rate of opioid dependence and the rate of deaths related to opioid overdose have been steadily rising. Concomitantly, the rate of opioid prescribing has been increasing. The primary objective of this project is to identify risk factors associated with the receipt of opioid prescriptions at hospital discharge after admission to a medical intensive care unit (MICU), specifically in patients who were not previously on opioid therapy. Our hypothesis is that patients who are given continuous infusions of opioids, especially for an extended length of time or at a high rate, have a higher risk of being discharged with a prescription for opioids than patients who did not receive the same magnitude of therapy. Furthermore, we believe that this risk may be higher in patients admitted after the publication of new guidelines by the Society of Critical Care Medicine in early 2013. Methods: This is a retrospective, case-control study in the MICU at the University of Vermont Medical Center, a rural, academic medical center in Burlington, Vermont. The MICU is a 21-bed closed unit. An electronic medical record was used to identify patients 18 years of age and older who were admitted to the MICU between January 1, 2010 and September 30, 2015. Patients were excluded if they had recent history of opioid use, required treatment in the operating room during or prior to the admission, were admitted for trauma, or were receiving comfort measures only. Results: A total of 3351 patient encounters were identified that met inclusion and exclusion criteria. Of these, 318 encounters resulted in at least one opioid prescription at hospital discharge. Baseline characteristics were similar between groups except more patients in the case group had mechanical ventilation (17.6% vs. 11.3%, p = 0.0007), chest tubes (2.4% vs. 0.4%, p = 0.0002), and PEG tubes (1.1% vs. 0.08%, p = 0.0021). Continuous infusions of opioids were given to 25 (6.8%) patients in the case group vs. 252 (7%) patients in the control group (p = 0.1). Conclusions: In this retrospective, case-control study, use of continuous infusions of opioids was not associated with the incidence of opioid prescribing at hospital discharge.
An Input-Series-Output-Parallel Converter System Exhibiting Natural Input-Voltage Sharing and Output-Current Sharing

Input-series-output-parallel (ISOP) converter system is suitable for high-input voltage applications owing to the reduced voltage stress of power switches. This article proposes an ISOP converter system with two-stage dc–dc converter as the basic module, which is composed by a non-isolated dc–dc converter and an isolated dc–dc converter. The isolated dc–dc converter functions as a dc transformer (DCX), and the non-isolated dc–dc converter serves as the pre- or post-regulator to regulate the output voltage. With this arrangement, a common duty ratio is applied to all the pre-or postregulators, and natural input-voltage sharing (IVS) and output-current sharing (OCS) can be achieved. The LLC resonant converter is adopted as the DCX, and the design considerations are given for achieving a nearly constant voltage gain even if there is parameters drift. Meanwhile, the non-isolated converter has simple topology and the parameters are easy to be identical. Thus, the proposed ISOP converter system realizes excellent IVS and OCS even the constituent modules are not well matched. Furthermore, the improved ISOP converter system employing boost+LLC resonant converter is proposed. Two 12-kW ISOP converter systems have been fabricated and tested in the lab, and the experimental results are provided to verify the natural voltage sharing of the proposed ISOP converter system.
Gene expression profiling identified TP53MutPIK3CAWild as a potential biomarker for patients with triple-negative breast cancer treated with immune checkpoint inhibitors

Triple-negative breast cancer (TNBC) accounts for 15–30% of all breast cancer cases and is clinically difficult to treat due to the lack of hormone or human epidermal growth factor receptor 2 receptors, which are usually targeted by the most successful therapeutic approaches. Immune checkpoint inhibitors (ICIs) have offered long-term survival benefits in several types of solid tumors, however with low response rates. Thus, there is an urgent need to develop feasible biomarkers for identifying patients with TNBC, who are responsive. The present study demonstrated that the immune microenvironment of TNBC has the highest expression of immunoregulatory molecules among all pathologic types. The tumor mutation burden (TMB) of TNBC was not strongly correlated with cytolytic activity and showed no significant associations with different degrees of immune cell infiltration and TMB. The machine learning method divided patients with TNBC into two groups characterized by ‘hot’ and ‘cold’ tumors, according to whether immune-associated genes were highly expressed, and different responses to immunotherapy were seen between these two groups. Furthermore, patients with a TP53MutPIK3CAWild genotype demonstrated favorable immunotherapy-responsive signatures and may have improved outcomes with ICIs. In conclusion, the present study revealed that TP53 and PIK3CA may be appropriate biomarkers to screen for patients who would benefit most from ICIs, which could guide precise immunotherapy for patients with TNBC.
The second complete chloroplast genome sequence of the Viburnum erosum (Adoxaceae) showed a low level of intra-species variations

Abstract We presented the second complete chloroplast genome of the plant. The length of chloroplast genome is 158,587 bp, consisting of four subregions: 87,050 bp of LSC and 18,503 bp of SSC regions separated by a pair of 26,517 bp IR regions. It includes 129 genes (84 protein-coding genes, 8 rRNAs, and 37 tRNAs). A low-level of molecular variation within Viburnum erosum was found with 16 SNPs and 49 indels. The phylogenetic tree shows that the two accessions of V. erosum are clustered with Viburnum japonicum with no resolution between the species, suggesting that chloroplast genome in these species evolve slowly.
SELECTION OF TREATMENT METHODS FOR BLEEDING ANEURYSMS

Whether to treat bleeding aneurysms surgically or by endovascular occlusion is a frequent subject of debate between neurosurgeons and radiologists. The aim was to take a general position on when to apply which method through the overview of the results that have been achieved so far. However, each patient must be seen as an individual in order for the right decision to be made. A prospective study of 336 patients who were treated at the Clinic of Neurosurgery in Nis for a ruptured aneurysm in the period between January 2007 and December 2010 has been conducted. Hunt-Hess grading system was used and the patients who were treated were those with grade I, II and III. Out of 336 bleeding aneurysms, embolization was used to treat 154 of them, whereas 282 patients underwent operative treatment. Embolization was a method of choice when dealing with aneurysms in the basilar flow, as well as in the initial segment of the carotid flow. Better results were obtained in patients treated, either surgically or endovascularly, 72 hours after the bleeding.
Assessment of First-Grade Students’ Literacy and Numeracy Levels and the Influence of Key Factors

The acquisition of literacy and numeracy in early years education provides children with an essential skill for learning and life. This study aims to assess the literacy and numeracy skills of first-graders in Qatari governmental schools. It also determines whether there is a relationship between numeracy skills and literacy skills and whether these are influenced by such factors as parents’ educational level, students’ prior knowledge, and gender. Study participants included 80 students (21 male, 59 female). The study used a quantitative research approach, and descriptive statistics were determined using Statistical Packages for Social Sciences (SPSS). The researchers used two research instruments: a numeracy survey and a literacy survey. The results demonstrated that participants attained a high level of oral language, phonological awareness, print awareness, knowledge of letters, and basic addition and subtraction facts with numbers 0–10. The results of the study also revealed that students possessed a medium level of writing development, place value, and adding and subtracting two-digit numbers and a low level of numeracy skills related to basic word problems, patterns, clocks, geometry, measuring, and money. In addition, the results demonstrated significant differences between male and female first-grade students, with male students having better literacy and numeracy skills than female students. The results s revealed no statistically significant differences in both literacy and numeracy related to pre-school knowledge, while there were significant differences in children’s literacy and numeracy related to parents’ educational level. These results were discussed and recommendations for practice and research were presented accordingly. https://doi.org/10.26803/ijlter.18. 12.11
Proposed Secured Bay-Salam Model for Financing Agriculture by Islamic Banks

Bay Salam is a type of forward contract between two parties to sell or buy a commodity set at agreed terms and conditions on a future date. The Bay Salam contract is beneficial for both buyer and seller because the seller receives full payment in advance while the buyer pays at a favourable price. Despite its benefits to farmers and vendors, this mode of financing is widely available. Therefore, this article aims to explore the concept of the Bay Salam contract and its potential application in financing the agricultural sector in contemporary banking system. This research adopts a qualitative approach by critically reviewing the literature and conducting semi-structured interviews with seven financial and agricultural experts in Nigeria using purposive sampling method. Findings show that Bay Salam is largely unpopular in modern days due to high level of risk and management responsibilities required for the financier. The novelty of this paper lies in the proposed model which combines the concept of Bay Salam and Takaful.
Ultramafic Carbonated Melt‐ and Auto‐Metasomatism in Mantle Eclogites: Compositional Effects and Geophysical Consequences

The mineralogy, chemical composition, and physical properties of cratonic mantle eclogites with oceanic crustal protoliths can be modified by secondary processes involving interaction with fluids and melts, generated in various slab lithologies upon subduction (auto‐metasomatism) or mantle metasomatism after emplacement into the cratonic lithosphere. Here we combine new and published data to isolate these signatures and evaluate their effects on the chemical and physical properties of eclogite. Mantle metasomatism involving kimberlite‐like, ultramafic carbonated melts (UM carbonated melts) is ubiquitous though not pervasive, and affected between ~20% and 40% of the eclogite population at the various localities investigated here, predominantly at ~60–150 km depth, overlapping cratonic midlithospheric seismic discontinuities. Its hallmarks include lower jadeite component in clinopyroxene and grossular component in garnet, an increase in bulk‐rock MgO ± SiO2, and decrease in FeO and Al2O3 contents, and LREE‐enrichment accompanied by higher Sr, Pb, Th, U, and in part Zr and Nb, as well as lower Li, Cu ± Zn. This is mediated by addition of a high‐temperature pyroxene from a UM carbonated melt, followed by redistribution of this component into garnet and clinopyroxene. As clinopyroxene‐garnet trace‐element distribution coefficients increase with decreasing garnet grossular component, clinopyroxene is the main carrier of the metasomatic signatures. UM carbonated melt‐metasomatism at >130–150 km has destroyed the diamond inventory at some localities. These mineralogical and chemical changes contribute to low densities, with implications for eclogite gravitational stability, but negligible changes in shear‐wave velocities, and, if accompanied by H2O‐enrichment, will enhance electrical conductivities compared to unenriched eclogites.
Hukou System Reform and Challenges

Hangi meslegi icra ettigine bakilmaksizin vatandasinin dogdugu yerde yasamasini ongoren Hukou Sistemi, 1950’li yillarda gocun onune gecmek uzere yururluge girmistir. Yururluge girdigi tarihten gunumuze kadar cesitli reformlara ugrayan soz konusu sistemin ana temasi kirsal nufussuzlasmanin engellenmesi ise de degisen beklentiler ve talepler sistemin sekillenmesine yardimci olmustur. Her ne kadar soz konusu sistem sehirlerin anarsi icinde kalmasini ve adeta duzensiz bir duzende kalmasini engelliyor olsa da, evde kalan cocuklar, ekonomik az gelismislik, esitsizlik ve sehirlesememe gibi sorunlar yaratmaktadir. Bu problemlerden oturu Cin Hukumeti 2013 yilinda aldigi bir kararla bu sistemde bazi degisiklikler yapmayi kararlastirmistir. Hem soz konusu degisikliklerin ne anlama geldigini kavrayabilmek hem de sistemi daha yakindan tanimak adina bu makalede sistem analiz edilerek tanimlanacak ve devaminda da ongorulen reformlarin onundeki engeller aciklanmaya calisilacaktir.
Occupations and the Non-Standard Employment Career: How the Occupational Skill Level and Task Types Influence the Career Outcomes of Non-Standard Employment

This article examines to what extent the occupational skill level and task types determine whether non-standard employment (NSE) leads to a stepping-stone or a trap in the careers of workers. For this purpose, a typology of the individual careers of workers in the Netherlands who entered non-standard employment in 2007 is created using multichannel sequence analysis. This typology allows for classifying careers in terms of employment security and income security. An analysis of this typology shows that working in occupations with high-level tasks does not preclude trap careers with low levels of employment and income security. Routine tasks do not have an unequivocal effect on career outcomes, while manual tasks generally lead to trap careers. The combination of routine and manual tasks makes it most likely for NSE to function as a trap in workers’ careers.
Hedging effectiveness assessment via value-at-risk (VaR) and conditional VaR: An empirical investigation for the Brazilian mango and grape exports

The aim of this paper was to identify the hedge effectiveness of hypothetical future contracts for the Brazilian mango and grape exports via Value-at-Risk (VaR) and Conditional VaR hedging approaches. To this end, it was used two nonparametric models: the Historical Simulation and the Kernel Distribution. It was collected 300 monthly average mango and grape prices US$ FOB/kg, between 1989 and 2013, from the site Comex Stat. As benchmarking model, it was also used the Minimum-Variance approach since it is widely employed by hedgers. The results showed that a variance reduction does not imply a VaR/CVaR reduction, and when it occurs, it does not happen in the same way. On the other hand, in general, the Minimum-CVaR via the Kernel method improve the reduction in portfolio’s VaR, CVaR, and variance when compared with the Minimum-Variance approach, with a smaller optimal hedge ratio. For mango, the contract with maturity at five months had the largest CVaR reduction in the validation sample, while for grape, the largest CVaR reduction occurred with maturity at four months. Abdinardo Moreira Barreto de Oliveira Universidade Tecnológica Federal do Paraná abdinardom@utfpr.edu. br Joséte Florêncio dos Santos Universidade Federal de Pernambuco jfs@ufpe.br Recebido em: 06/03/2018. Aprovado em: 06/11/2019. Avaliado pelo sistema double blind review Avaliador científico: Renato Silvério Campos DOI: 10.21714/2238-68902018v20n2p134 RESUMO O objetivo deste artigo foi identificar a efetividade do hedge em contratos futuros hipotéticos para as exportações brasileiras de manga e uva via abordagens de hedging do Valor-em-Risco (VaR) e do VaR condicional. Para esse propósito, foram usados dois modelos não paramétricos: a Simulação Histórica e a Distribuição Kernel. Coletou-se 300 preços médios mensais US$ FOB/kg de manga e uva entre 1989 e 2013 no site Comex Stat. Como modelo de comparação, também foi usada a abordagem da Variância Mínima, por causa de seu amplo uso pelos hedgers. Os resultados mostraram que uma redução na variância não implica numa redução no VaR/CVaR, e quando isso ocorre, não acontece da mesma maneira. Por outro lado, pode-se notar que, geralmente, o Mínimo-CVaR via método Kernel aumenta a redução do VaR, do CVaR e da variância, em vez da abordagem da Variância Mínima, com uma razão ótima de hedge menor. Para a manga, o contrato com vencimento em cinco meses foi o que teve a maior redução do CVaR na amostra de validação, enquanto que para a uva, a maior redução do CVaR ocorreu com o vencimento em quatro meses.
Towards More Robust Uplift Modeling for Churn Prevention in the Presence of Negatively Correlated Estimation Errors

The subscription economy is rapidly growing, boosting the importance of churn prevention. However, current true lift models often lead to poor outcomes in churn prevention campaigns. A vital problem seems to lie in instable estimations due to dynamic surrounding parameters such as price increases, product migrations, tariff launches of a competitor, or other events with uncertain consequences. The crucial challenge therefore is to make churn prevention measures more reliable in the presence of game-changing events. In this paper, we assume such events to be spatially finite in feature space, an assumption which leads to particularly bad churn prevention results if the selected customers lump in an affected region of the feature space. We then introduce novel methods which trade off uplift for reduced similarity in feature space when selecting customers for churn prevention campaigns and show that these methods can improve the robustness of uplift
Perceived challenges faced by family caregivers of chronic kidney disease patients and suggested solutions: A qualitative study

conditions, and type of treatment chosen. [6] Caregivers actually fill the service gaps that Background: The role of family caregivers in the provision of palliative care services to patients with chronic kidney disease (CKD) is substantial. They encounter many hurdles in the process of caregiving. If not taken care properly, it results in poor quality of service offered to patients and also affects the health of the caregivers. Objectives: To explore the perceived challenges of caregivers of CKD patients on regular dialysis and to identify the suggested solutions for the same. Materials and Methods: It was a phenomenological type of qualitative study carried out using in-depth interviews by researchers trained in qualitative methods among the 18 caregivers of the patients with CKD. Responses given in Tamil were noted down verbatim and were translated into English. The manual content analysis was carried out. Ethical principles have adhered. Results: Descriptive coding of the text information was done, and later, similar codes were merged together to form the categories. Eight broad categories emerged each under the theme of perceived challenges of caregivers and suggested solutions to them. They were (1) family or day-to-day life related; (2) psychological; (3) financial; (4) social; (5) spiritual; (6) physical; (7) treatment-related; and (8) travel-related issues. Conclusion: Providing support for family caregivers is considered as a key component of palliative care. Multicomponent interventions involving various stakeholders are required to address the challenges faced by the caregivers. Effective coordination among family members, community volunteers, health system, and government for the betterment of caregivers is the main need. ABSTRACT
Prevalence of Cancerous and Pre-malignant Lesions of Cervical Cancer and their Association with Risk Factors as seen among women in the Regions of Uganda

1Department of Pathology, College of Health Sciences, Makerere University, Kampala, Uganda 2Department of Pathology, School of Biomedical Sciences, Makerere University College of Health Sciences (MakCHS) Kampala, Uganda 3Busitema University, Faculty of Medicine, Department of Obstetrics and Gynaecology. Tororo, Uganda 4Department of Obs and Gyn. Mulago Hospital complex, Kampala, Uganda Received date: 07 Feb 2017; Accepted date: 01 Mar 2017; Published date: 06 Mar 2017.
Numerical simulation of two-way fluid-structure interaction of wind loading on buildings

ABSTRACT Fluid-structure interaction has been largely utilized in wind turbine, but the related studies on building wind loading are relatively less frequent. In this study, a numerical study was carried out to investigate the wind load characteristics of a building based on two-way fluid-structure interaction, where synchronous interactions between wind and building were considered. Based on the comparison with experiments, it was indicated that a grid size of 0.4 m is adequate for a 6 m cube model and a computational zone with a domain of 25 m high and 50 m long is enough for the target problem in this study. It was also known that large eddy simulation provides the best fit with experiments, followed by detached eddy simulation, where the k-ε, k-ω and shear stress transport models give higher predictions. To provide reliable numerical results for building wind analysis, a computational domain with at least 4 times of the building height and 8 times of building length were suggested, while no strict requirement was shown for the domain width when it is longer than 20 m. The research outcomes can provide a technical guide on the applications of building wind analysis.
Growth, Yield, and Water Productivity Responses of Pepper to Sub-Irrigated Planter Systems in a Greenhouse

A sub-irrigated planter (SIP) is a container irrigation technique in which water is supplied to the crop from the bottom, stored in a saturated media-filled reservoir beneath an unsaturated soil, and then delivered by capillary action to the root zone. The aim of this study was to optimize the water management and to assess the performance of this technique in terms of water use efficiency, soil moisture, and solute distribution in comparison with surface irrigation in a Mediterranean greenhouse. The experiment consisted of four SIP treatments, with a constant water level in the bottom reservoir in order to evaluate the effect of two different irrigation salinities (1.2 and 2.2 dS m−1) and two depths of substrate profiles (25 and 15 cm). The results showed that SIP is capable of significantly improving both water-use efficiency and plant productivity compared with surface irrigation. Also, a 24% average reduction in water consumption was observed while using SIP. Moreover, SIPs with a higher depth were recommended as the optimum treatments within SIPs. The type of irrigation method affected the salinity distribution in the substrate profile; the highest salinity levels were registered at the top layers in SIPs, whereas the maximum salinity levels for the surface treatments were observed at the bottom layers. SIPs provide a practical solution for the irrigation of plants in areas facing water quality and scarcity problems.