Miracle-dz/UniFAR-FTUs huggingface dataset:
Environmental, Human and Ecotoxicological Impacts of Different Rice Cultivation Systems in Northern Thailand

Sustainable practices in rice cultivation require effective farming management concerning environmental and human health impacts. In this study, three rice cultivation systems, namely low-land, upland, and terraced rice in the Mae Chaem District, Chiang Mai Province, were assessed and the carbon footprint (CF), water footprint (WF), and human and ecotoxicological impacts were compared from pesticide application. The results showed that the highest CF intensity was observed in terraced rice with 1.15 kg CO2eq kg−1 rice yield, followed by lowland rice (1.02 kg CO2eq kg−1 rice yield) and upland rice (0.17 kg CO2eq kg−1 rice yield) fields. Moreover, lowland rice cultivation generated the highest total WF with 1701.6 m3 ton−1, followed by terraced rice (1422.1 m3 ton−1) and upland rice (1283.2 m3 ton−1). The lowland rice fields had the most impact on human health and freshwater ecotoxicity, followed by the terraced and upland rice cultivation systems. The results also showed that most of the pesticides remaining in soils were chlorpyrifos (98.88%), butachlor (96.94%), and fipronil (95.33%), respectively. The substances with the greatest distributions in freshwater were acephate (56.74%), glyphosate (50.90%), and metaldehyde (45.65%), respectively. This study indicated that, with more agricultural inputs, higher CF, WF, human health impacts, and freshwater ecotoxicity were generated. Although the use of pesticides in the study areas did not exceed the recommendations on the packaging, glyphosate and chlorpyrifos are restricted in Thailand, so it is necessary to monitor their use due to their long-term health effects.
Strong Feller Property and Irreducibility for Diffusions on Hilbert Spaces

It is shown that the transition semigroup $(P_t)_{t\geq0}$ corresponding to a nonlinear stochastic evolution equation is strong Feller and irreducible, provided the nonlinearities are Lipschitz continuous and the diffusion term is nondegenerate. This result ensures the uniqueness of the invariant measure for $(P_t)_{t\geq0}$.
Seminal Bacterioflora of Two Rooster Lines: Characterization, Antibiotic Resistance Patterns and Possible Impact on Semen Quality

This study aimed to characterize the bacterial profiles and their association with selected semen quality traits among two chicken breeds. Thirty Lohmann Brown and thirty ROSS 308 roosters were selected for semen quality estimation, including sperm motility, membrane and acrosome integrity, mitochondrial activity, and DNA fragmentation. The oxidative profile of the semen, including the production of reactive oxygen species (ROS), antioxidant capacity, protein, and lipid oxidation, were assessed as well. Moreover, the levels of pro-inflammatory cytokines, including tumor necrosis factor alpha (TNF-α), interleukins 1 and 6 (IL-1, IL-6) and C-reactive protein, as well as the concentrations of selected antibacterial proteins (cathelicidin, β-defensin and lysozyme) in the seminal plasma were evaluated with the enzyme-linked immunosorbent assay. The prevailing bacterial genera identified by the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry were Citrobacter spp. , Enterococcus spp. , Escherichia spp. and Staphylococcus spp. While the bacterial load was significantly higher in the ROSS 308 line (p < 0.05), a higher number of potentially uropathogenic bacteria was found in the Lohmann Brown roosters. Antimicrobial susceptibility tests revealed a substantial resistance of randomly selected bacterial strains, particularly to ampicillin, tetracycline, chloramphenicol, and tobramycin. Furthermore, Lohmann Brown ejaculates containing an increased proportion of Escherichia coli presented with significantly (p < 0.05) elevated levels of TNF-α and IL-6, as well as ROS overproduction and lipid peroxidation. Inversely, significantly (p < 0.05) higher levels of β-defensin and lysozyme were found in the semen collected from the ROSS 308 roosters, which was characterized by a higher quality in comparison to the Lohmann Brown roosters. In conclusion, we emphasize the criticality of bacteriospermia in the poultry industry and highlight the need to include a more complex microbiological screening of semen samples designated for artificial insemination.
Adiponectin Increase in Patients Affected by Chronic Obstructive Pulmonary Disease with Overlap of Bronchiectasis

Chronic obstructive pulmonary disease (COPD) is characterized by respiratory symptoms and non-reversible airflow limitation with recurrent episodes of acute exacerbations. The concurrent presence of bronchiectasis in patients with COPD is associated with reduced respiratory function as well as increased exacerbation risk. Adiponectin is a promising biomarker in COPD, as greater high molecular weight (HMW) oligomer levels have been observed among COPD patients. Here, we investigate adiponectin levels in two groups of COPD patients characterized by the presence or absence of bronchiectasis (BCO), comparing both groups to healthy controls. We evaluated serum adiponectin levels in COPD patients, those with BCO, and healthy subjects and characterized the pattern of circulating adiponectin oligomers. We found that forced volume capacity % (FVC%) and forced expiratory volume % (FEV1%) were lower for BCO patients than for COPD patients. COPD patients had higher levels of adiponectin and its HMW oligomers than healthy controls. Interestingly, BCO patients had higher levels of adiponectin than COPD patients. We showed that expression levels of IL-2, -4, and -8, IFN-γ, and GM-CSF were significantly higher in BCO patients than in healthy controls. Conversely, IL-10 expression levels were lower in BCO patients. Our data suggest that the increased levels of adiponectin detected in the cohort of BCO patients compared to those in COPD patients without bronchiectasis might be determined by their worse airway inflammatory state. This hypothesis suggests that adiponectin could be considered as a biomarker to recognize advanced COPD patients with bronchiectasis.
Stick and slip phenomena during extrusion of polyethylene melts as investigated by laser-Doppler velocimetry

The flow behavior of polyethylene melts in a slit die was investigated using laser-Doppler velocimetry. Two polyethylenes, a linear and a long-chain branched sample, were compared in order to get an insight into the influence of branching on stick and slip phenomena. For the long-chain branched polyethylene, velocity profiles were obtained which do not give any indication to wall slip in the range of shear rates applied. For the linear polyethylene, the velocity distributions in the three regions, commonly distinguished by different pressure-output relations in the literature, were measured. Pronounced wall slip velocities are detected at low apparent shear rates. The importance of this finding for the determination of viscosity functions is discussed. At higher output rates the well-known pressure oscillations are accompanied by velocity fluctuations of the same frequency but totally different shapes of amplitudes. Significant periodic features of the time dependence of the velocity are tried to be inter.
The Search of Association of HLA Class I and Class II Alleles with COVID-19 Mortality in the Russian Cohort

HLA genes play a pivotal role in the immune response via presenting the pathogen peptides on the cell surface in a host organism. Here, we studied the association of HLA allele variants of class I (loci A, B, C) and class II (loci DRB1, DQB1, DPB1) genes with the outcome of COVID-19 infection. We performed high-resolution sequencing of class HLA I and class II genes based on the sample population of 157 patients who died from COVID-19 and 76 patients who survived despite severe symptoms. The results were further compared with HLA genotype frequencies in the control population represented by 475 people from the Russian population. Although the obtained data revealed no significant differences between the samples at a locus level, they allowed one to uncover a set of notable alleles potentially contributing to the COVID-19 outcome. Our results did not only confirm the previously discovered fatal role of age or association of DRB1*01:01:01G and DRB1*01:02:01G alleles with severe symptoms and survival, but also allowed us to single out the DQB1*05:03:01G allele and B*14:02:01G~C*08:02:01G haplotype, which were associated with survival. Our findings showed that not only separate allele, but also their haplotype, could serve as potential markers of COVID-19 outcome and be used during triage for hospital admission.
COPING WITH BURNOUT? MEASURING THE LINKS BETWEEN WORKPLACE CONFLICTS, WORK-RELATED STRESS, AND BURNOUT

Purpose. The aim of the paper is to investigate the relationship between workplace conflicts and employee burnout. Design/methodology/approach. The survey method was chosen, and the questionnaire was posted online to share among Lithuanian employees. Finally, 495 employees completed the questionnaire, which included four parts: questions about workplace conflicts, burnout, burnout due to conflicts, and consequences of burnout. Statistical analysis was used to process the research data. Findings. The study revealed that the more conflicts employees have with clients, colleagues, or managers, the more burnout they experience as a consequence. Furthermore, conflicts with colleagues have the strongest relationship with consequences of burnout which are not as unambiguous as they may also be the outcome of burnout. Research limitations/implications. The study was conducted in Lithuania and revealed the conflict-induced burnout of employees and the consequences of the burnout they face. Practical implications. Understanding the links between conflict at work and burnout let organizational leaders prioritize conflict resolution, pay more attention to the mental health of employees, and protect the organization from the costly consequences of burnout. Originality/Value. This study reveals the consequences of labour conflicts not only in the context of burnout but also in its consequences which allow to understand the real threat of disputes.
Service Innovation and Value Creation in Local Journalism During Times of Crisis

ABSTRACT Journalism innovation, according to service innovation theory, is about providing new journalistic services that create value for audiences, society, and the news organisation itself. This study explores how local news media responded to the Coronavirus crisis in terms of service innovation. Based on interviews with editors and top management representatives at two local newspaper groups in Norway (N = 20), we show how local newspapers developed new digital services in response to audiences’ need for guidance, overview, and a sense of togetherness, and how the media operations generated revenues in the process. Theoretically, the study identifies two key innovation dynamics in local journalism during a crisis: A social-economic value creation dynamic which captures how local newspapers appropriate their business model to accommodate new service offerings and balance social and economic value creation considerations; and a service system-audience experience dynamic which captures how innovation in journalistic offerings are linked to concurrent innovations in journalistic production processes. This research enhances the understanding of journalism innovation as a value-creating phenomenon and the factors that stimulate such value creation during crises.
Fetuin-A: A Novel Biomarker of Bone Damage in Early Axial Spondyloarthritis. Results of an Interim Analysis of the SPACE Study

Our study aimed to evaluate the association between fetuin-A levels and the presence of radiographic sacroiliitis and syndesmophytes in patients with early axial spondyloarthritis (axSpA) and to identify potential predictors of radiographic damage in the sacroiliac joints (SIJs) after 24 months. Patients diagnosed with axSpA in the Italian cohort of the SpondyloArthritis-Caught-Early (SPACE) study were included. Physical examinations, laboratory tests (including fetuin-A), SIJ,+ and spinal X-rays and MRIs at T0 (diagnosis) and at T24 were considered. Radiographic damage in the SIJs was defined according to the modified New York criteria (mNY). Fifty-seven patients were included in this analysis (41.2% male, median (interquartile range), chronic back pain [CBP] duration of 12 (8–18) months). Fetuin-A levels were significantly lower in patients with radiographic sacroiliitis compared to those without at T0 (207.9 (181.7–215.9) vs. 239.9 (217.9–286.9), respectively, p < 0.001) and at T24 (207.6 (182.5–246.5) vs. 261.1 (210.2–286.6) µg/mL, p = 0.03). At T0, fetuin-A levels were significantly higher in non-smokers, in patients with heel enthesitis and in those with a family history of axSpA; fetuin-A levels at T24 were higher in females, in patients with higher ESR or CRP at T0 and in those with radiographic sacroiliitis at T0. Fetuin-A levels at T0 were independently negatively associated with the likelihood of radiographic sacroiliitis (OR = 0.9 per 10-unit increase (95% CI 0.8, 0.999), p = 0.048); but not with the presence of syndesmophytes. After adjustment for confounders, fetuin-A levels at T0 and T24 were also negatively associated with mNY at T0 (β −0.5, p < 0.001) and at T24 (β −0.3, p < 0.001), respectively. Among other variables at T0, fetuin-A levels did not achieve statistical significance in predicting mNY at T24. Fetuin-A levels were negatively associated with radiographic damage of the SIJs, but not of the spine, in early axSpA and after 2 years of follow-up. Our findings suggest that fetuin-A levels may serve as a biomarker to identify patients with a higher risk of developing severe disease and early structural damage.
Searching for $p$-adic eigenfunctions

In doing p-adic analysis on spaces of classical modular functions and forms, it is convenient and traditional to broaden the notion of “modular form” to a class called “overconvergent p-adic modular forms. ” Critical for the analysis of the p-adic Banach spaces composed of this wider class of forms is the “Atkin U -operator”, which is completely continuous and whose spectral theory (still not very well understood) seems to be the key to a good deal of arithmetic. The part of the spectrum of U corresponding to eigenvalues which are p-adic units is somewhat more understood, thanks to the work of Hida. As for the rest of the spectrum, it is surprising how fragmentary our information is (although recent work of Coleman, resolving in part some prior conjectures of ours, has improved the situation). We have begun an experimental search for nonclassical (but “overconvergent”) eigenfunctions in a fairly simple way. We take a number of classical modular functions which are p-adically overconvergent (e.g., j, 1/j,.), and try to find their p-adic “U -eigenfunction expansion. ” There is a straightforward computational procedure to approximate such eigenfunction expansions, even though, on a theoretical level, we do not even know that the “expansions” that our algorithm produces converge in any sense, or even settle down numerically. Experimentally, they seem to, and they produce candidate Fourier expansions. In our computations, we specialize principally to p = 5. The same eigenfunctions (produced by our algorithm) seem to occur as terms in each of the eigenfunction expansions we have calculated. This leads us to suspect that we have in fact encountered all the 5-adic eigenfunctions
The Effect of Parity on the Quality of Colostrum of Holstein Dairy Cows in the Organic Production System

Simple Summary It should be emphasized that bovine placenta limits the transfer of immunoglobulins (Ig) between the mother and the fetus. Placental membranes are characterized by limited permeability, and only gases and small particles can penetrate through them; therefore, calves are born with minimal levels of antibodies. The quality of colostrum is shaped by environmental and genetic factors. It should be emphasized that the amount of colostrum produced is negatively correlated with its density and the basic chemical composition (protein, fat). So, its quality decreases as the amount of colostrum produced increases. Cows’ parity is also a modulating factor, and studies have shown an increase in colostral IgG corresponds with increasing parity. A special feature of organic production systems is the cows’ significantly lower productivity, which is adapted to environmental conditions. The research hypothesis proposes the verification of the statement: the organic system has a positive impact on the quality of colostrum. The aim of the study was to determine the effect of cows’ parity on the quality of colostrum, in an organic farm setting. Abstract A special feature of organic production systems is the cows’ significantly lower productivity, which is adapted to environmental conditions. The quantity and quality of colostrum is negatively correlated, high amounts of colostrum are associated with low amounts of immunoglobulins. Cows’ parity is also a modulating factor, and studies have shown an increase in colostral IgG corresponds with increasing parity. This study’s aim was to determine the effect of cows’ parity on colostrum quality, in an organic farm setting. From a basic organic herd of dairy cattle, 40 Polish Holstein–Friesian cows were selected: 10 cows each of primiparous, second lactation, fourth lactation, and fifth lactation. Colostrum and transition milk samples were taken from each cow seven times: twice daily on the 1st and 2nd days after calving (every 12 h), and once daily on the 3rd to 5th days. Multiparous cows’ colostrum had higher levels of total proteins, casein, and non-fat dry matter, versus primiparous. Only cows in the second and fourth lactations produced very good quality colostrum (with immunoglobulins over 50 g/L), meeting standards for immunoglobulin concentration. In conclusion, the production of very good quality colostrum is limited during the first lactation, which may suggest the mammary gland is poorly developed, and, thus, immunoglobulin transport is limited. Variability in the colostrum’s immunoglobulin content from first and second collections post-calving was higher in multiparous versus primiparous cows. Therefore, it should be good practice to freeze colostrum from multiparous cows in case of poor-quality primiparous colostrum.
Immediate Effects of Myofascial Release Treatment on Lumbar Microcirculation: A Randomized, Placebo-Controlled Trial

(1) Background: Inflammatory processes in the thoracolumbar fascia (TLF) lead to thickening, compaction, and fibrosis and are thought to contribute to the development of nonspecific low back pain (nLBP). The blood flow (BF) of fascial tissue may play a critical role in this process, as it may promote hypoxia-induced inflammation. The primary objective of the study was to examine the immediate effects of a set of myofascial release (MFR) techniques on the BF of lumbar myofascial tissue. The secondary objectives were to evaluate the influence of TLF morphology (TLFM), physical activity (PA), and body mass index (BMI) on these parameters and their correlations with each other. (2) Methods: This study was a single-blind, randomized, placebo-controlled trial. Thirty pain-free subjects (40.5 ± 14.1 years) were randomly assigned to two groups treated with MFR or a placebo intervention. Correlations between PA, BMI, and TLFM were calculated at baseline. The effects of MFR and TLFM on BF (measured with white light and laser Doppler spectroscopy) were determined. (3) Results: The MFR group had a significant increase in BF after treatment (31.6%) and at follow-up (48.7%) compared with the placebo group. BF was significantly different between disorganized and organized TLFM (p < 0.0001). There were strong correlations between PA (r = −0.648), PA (d = 0.681), BMI (r = −0.798), and TLFM. (4) Conclusions: Impaired blood flow could lead to hypoxia-induced inflammation, possibly resulting in pain and impaired proprioceptive function, thereby likely contributing to the development of nLBP. Fascial restrictions of blood vessels and free nerve endings, which are likely associated with TLFM, could be positively affected by the intervention in this study.
Finite Element Analysis of Human Femur by Reverse Engineering Modeling Method

The femur is one of the most highly loaded bones of the human body and its fracture is a devastating event, especially for the elderly people that the surgery is so difficult for them and athletes that it may occurs after substantial trauma. The one-year mortality after hip/femur fracture is about twenty percent and twenty percent of those living in the community at the time of their femur fracture have to be admitted to a nursing home. In this study have been used the three dimensional finite element model of the human femur that it had been constructed by means of the reverse engineering method and unlike many previous works, in this issue had been used full model instead of partial or half model and this three dimensional finite element model has been analyzed under single, expanded and partial expanded loads. The material is assumed to have isotropic elastic characteristics. The results indicated, there are two region for the maximum stresses and this kind of finite element model and its simplification has been verified with the published experimental results and this study has shown that the real produced stress-strain distribution at the human femur when a person was in the single-leg stance phase of normal running or jumping for the first time.
The Possible Ameliorating Role of Fisetin on Hepatic Changes Induced by Fluoxetine in Adult Male Albino Rats: Histological, Immunohistochemical, and Biochemical Study

Background: Fluoxetine (FLX) is one of the selective serotonin reuptake inhibitors, it is widely used to treat neuropsychiatric disorders including depression, but high doses can cause several adverse effects. Fisetin (FIS), a bioactive flavonoid presents in vegetables and fruits, has antioxidant, anti-inflammatory, and anticancer effects. Aim: To evaluate the possible ameliorating effect of FIS on the hepatic alterations induced by FLX in adult male albino rats. Materials and Methods: Our study was done, for 3-weeks, on 48 rats that were divided into four groups: Group I (control), Group II received FIS orally (100 mg/kg/day), Group III received FLX orally (10 mg/kg/day), and Group IV concomitantly received FLX and FIS at the same dose and manner of groups II and III. Blood and liver samples were obtained and prepared for histological, immunohistochemical, and biochemical studies. Results: FLX group revealed disturbed liver architecture, hepatocytes with vacuolated cytoplasm, inflammatory cellular infiltration, blood extravasation, and congestion of blood vessels in addition to, a significant increase in the area percentage of caspase-3, inducible nitric oxide synthase and the number of glial fibrillary acidic protein-expressing cells as well as a significant decrease in the area percentage of periodic acid–Schiff stain. Moreover, FLX significantly increased aspartate-aminotransferase and alanine-aminotransferase levels in the serum. In addition, FLX increased malondialdehyde level and decreased superoxide dismutase, glutathione (GSH) peroxidase, and reduced GSH levels in liver tissue. The concomitant administration of FIS ameliorated these alterations. Conclusions: Administration of FIS ameliorated the histological, immunohistochemical, and biochemical alterations induced by FLX in the liver of adult male albino rats.