Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolic Biomarkers Assessed with PET/CT Predict Sex-Specific Longitudinal Outcomes in Patients with Diffuse Large B-Cell Lymphoma

Simple Summary There is a sex disparity in lymphoma where males have higher incidence and mortality compared to females. Sex differences in metabolism may be a significant factor underlying this phenomenon where visceral obesity, a known biomarker for poor outcomes in multiple pathophysiological states, is higher in males compared to females. Here, we report that visceral fat, although higher in males with diffuse large B-cell lymphoma (DLBCL), selectively predicted worse outcomes in females. Moreover, females that selectively gained visceral fat during chemotherapy did worse, and combining the change in visceral fat over the course of chemotherapy and tumor glucose uptake measured by FDG-PET at end of treatment identified a subgroup of females with extremely poor outcomes. Abstract In many cancers, including lymphoma, males have higher incidence and mortality than females. Emerging evidence demonstrates that one mechanism underlying this phenomenon is sex differences in metabolism, both with respect to tumor nutrient consumption and systemic alterations in metabolism, i.e., obesity. We wanted to determine if visceral fat and tumor glucose uptake with fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) could predict sex-dependent outcomes in patients with diffuse large B-cell lymphoma (DLBCL). We conducted a retrospective analysis of 160 patients (84 males; 76 females) with DLBCL who had imaging at initial staging and after completion of therapy. CT-based relative visceral fat area (rVFA), PET-based SUVmax normalized to lean body mass (SULmax), and end-of-treatment FDG-PET 5PS score were calculated. Increased rVFA at initial staging was an independent predictor of poor OS only in females. At the end of therapy, increase in visceral fat was a significant predictor of poor survival only in females. Combining the change in rVFA and 5PS scores identified a subgroup of females with visceral fat gain and high 5PS with exceptionally poor outcomes. These data suggest that visceral fat and tumor FDG uptake can predict outcomes in DLBCL patients in a sex-specific fashion.
Notes on the Treatment of Charged Particles for Studying Cyclotide/Membrane Interactions with Dissipative Particle Dynamics

Different charge treatment approaches are examined for cyclotide-induced plasma membrane disruption by lipid extraction studied with dissipative particle dynamics. A pure Coulomb approach with truncated forces tuned to avoid individual strong ion pairing still reveals hidden statistical pairing effects that may lead to artificial membrane stabilization or distortion of cyclotide activity depending on the cyclotide’s charge state. While qualitative behavior is not affected in an apparent manner, more sensitive quantitative evaluations can be systematically biased. The findings suggest a charge smearing of point charges by an adequate charge distribution. For large mesoscopic simulation boxes, approximations for the Ewald sum to account for mirror charges due to periodic boundary conditions are of negligible influence.
The Diagnostic Performance of 18F-FDG PET/CT in Recurrent Pancreatic Cancer: A Systematic Review and Meta-analysis

Purpose The CT scan is the best common screening test for pancreatic cancer recurrence after surgery. The goal of our meta-analysis was to assess the diagnostic accuracy of 18F-FDG PET/CT for pancreatic cancer recurrence. Methods We examined PubMed and Embase for suitable papers between 2009 and 2022. The researchers considered studies that looked at the diagnostic usefulness of 18F-FDG PET/CT in identifying local and/or distant disease recurrence throughout the follow-up following pancreatic cancer resection. The Quality Assessment of Diagnostic Performance Studies-2 (QUADAS-2) method was used to evaluate the quality of each study. For each of the publications included, two researchers extracted data independently. The extracted data included general data (authors, year of publication), literature characteristics (country, type of literature, and design of study), characteristics of the patient (patients' number, mean or median age, and treatment regimen), and technical aspects (scanner, injection activity, and image analysis). Results The analysis includes 7 trials with a total of 263 patients. The sensitivity and specificity of 18F-FDG PET/CT in detecting recurrent pancreatic cancer following definitive treatment were 0.89 (95 percent CI: 0.83-0.93) and 0.88 (95 percent CI: 0.72-0.96), respectively, according to the pooled estimates. PET/CT performed well in the diagnosis of recurrent pancreatic cancer, with an AUC of 0.94. (0.91-0.95). Conclusions 18F-FDG PET-CT was found to be a reliable detection method in recurrent pancreatic tumor.
Antioxidant and Immunostimulatory Activities of Fermented Sour Soybean Milk Added With Polypeptides From Pleurotus eryngii

The improved quality of sour soybean milk by adding polypeptide from Pleurotus eryngii was investigated in this study, and the immunomodulatory effect of sour soybean milk fermented with polypeptides from P. eryngii was also evaluated in immunosuppressed mice induced by cyclophosphamide. Results showed the physicochemical property of sour soybean milk fermented with small-molecular-weight polypeptide (<3 kDa) were superior to the others including the decrease of pH, and increase of acidity, water-holding capacity and lactic acid bacteria count. The animal experiment demonstrated that sour soybean milk with polypeptide could effectively reverse the decreasing trend of thymus/spleen index and hematological parameters, enhance murine immune functions including serum hemolysin and splenic lymphocyte proliferation, and inhibit oxidative stress. In addition, sour soybean milk fermented with polypeptide could increase the diversity of intestinal flora, and increase the abundances of Firmicutes, Bacteroides, and Lactobacillus. Taken together, it could provide a theoretical basis for developing an immunomodulatory agent or functional food additives with antioxidant activity.
Updates in the Role of Checkpoint Inhibitor Immunotherapy in Classical Hodgkin’s Lymphoma

Simple Summary The introduction of immunotherapy into the treatment options for Hodgkin’s lymphoma has improved survival in patients with recurrence of their cancer. These agents help the body’s immune system respond and clear cancer cells. Currently, these agents are only approved in patients who have had their cancer return multiple times or have progressed through multiple therapies. However, the evaluation of these agents as part of therapy in the upfront setting or second line setting has been conducted. This study will review these clinical studies and provide insights into the future directions of immunotherapy use by physicians in treatment of patients with Hodgkin’s lymphoma. Abstract Classical Hodgkin’s lymphoma is a highly curable disease, but 10–25% of patients with higher-risk disease relapse. The introduction of checkpoint inhibitors (CPIs) targeting PD-1 have changed the landscape of treatment for patients with relapsed/refractory disease to multiple lines of therapy. The depth of response to CPI as a monotherapy is highest in the first relapse as salvage therapy based on outcomes reported in several phase II studies. With earlier use of CPI and brentuximab vedotin, the optimal sequencing of therapy is evolving. In this review, we will summarize clinical investigation of anti-PD-1 mAb in earlier line settings to provide insights on utilizing these agents as chemotherapy- and radiation-sparing approaches, increasing depth of response, and as part of combination regimens.
Happy to Be a Boss? Cultural Moderators of Relationships Between Supervisory Responsibility and Job Satisfaction

This paper addresses whether supervisory responsibility is a challenging job demand in the Job Demands-Resources (JD-R) model in different cultural contexts. We investigate how job satisfaction responds to a supervisory role with job control and selected cultural dimensions using a cross-cultural dataset of 14 countries with more than 43,000 adults using ordered logit regression models. We find that a supervisory role enhances job satisfaction and appears to be a challenging job demand. However, no studied cultural dimension, masculinity, power distance, individualism, or uncertainty avoidance, increases job satisfaction derived from this kind of responsibility. Our study indicates that there might be stereotypical assumptions about cultural dimensions concerning the job satisfaction of supervisors.
Effect of grower dietary energy level on feed intake and performance of modern broiler chickens

An experiment was carriedout to investigate the effect of dietary energy level levels on feed intake of modern broiler chickens during the growth period. A total of 160 Ross broiler chicks (mixed-sex) in a completely randomized design with 4 treatments and 4 replicates (10 birds) were used. The chicks were fed from 11 to 24 days of age with dietary treatments, including 4 grower diets with 2800, 2900, 3000, and 3100 kcal/kg ME and constant nutrient to ME ratios. All chicks were fed the recommended Ross diet during starter (1- 10 days) and finisher (25- 42 days) periods. At the end of experimentperiod (42 days), growth performance and carcass characteristics were measured.The results showed that the energy level had no significant effect on the average daily feed intake for the grower period, but the grower's dietary energy level had a significant effect on daily body weight gain and feed conversion ratio.Also, there was no significant difference in final live weight and relative carcass yield at the end of theexperimentalperiod. In conclusion, during the growing period, modern broiler chicks consume feed regardless of the energy level of the diet and continue up to physical satiety.
Microglial Priming in Infections and Its Risk to Neurodegenerative Diseases

Infectious diseases of different etiologies have been associated with acute and long-term neurological consequences. The primary cause of these consequences appears to be an inflammatory process characterized primarily by a pro-inflammatory microglial state. Microglial cells, the local effectors’ cells of innate immunity, once faced by a stimulus, alter their morphology, and become a primary source of inflammatory cytokines that increase the inflammatory process of the brain. This inflammatory scenario exerts a critical role in the pathogenesis of neurodegenerative diseases. In recent years, several studies have shown the involvement of the microglial inflammatory response caused by infections in the development of neurodegenerative diseases. This has been associated with a transitory microglial state subsequent to an inflammatory response, known as microglial priming, in which these cells are more responsive to stimuli. Thus, systemic inflammation and infections induce a transitory state in microglia that may lead to changes in their state and function, making priming them for subsequent immune challenges. However, considering that microglia are long-lived cells and are repeatedly exposed to infections during a lifetime, microglial priming may not be beneficial. In this review, we discuss the relationship between infections and neurodegenerative diseases and how this may rely on microglial priming.
Prevalence of Diabetic Foot Ulcer Admission; A Retrospective Study at the Rivers State University Teaching Hospital, Port Harcourt

Background: Diabetes mellitus is a glucose metabolic disorder with major complications ranging from tissue damage to issues with internal organs. Its prevalence keeps increasing at a very alarming rate and so does its major complication, foot ulcer, which constitutes to both economic burden and human suffering. Aims: The study aimed to establish the prevalence of diabetic foot ulcer (DFU) hospitalised adult patients in Rivers State University Teaching Hospital, Port Harcourt, Nigeria. Methods: A retrospective study was conducted on all DFU patients admitted in the Medical ward at the Rivers State University Teaching Hospital, Port Harcourt, Nigeria. Study variables included age and gender in. Data was processed for the 96 DFU patients. Result: A total of 96 DFU diabetic patients were studied with Male to Female ratio of about 1:2. Prevalence of diabetes was 7.8% with more cases in women (64.4%) than in men (35.6%). The prevalence of diabetic foot ulcer in relation to age was highest in the age group 60 years and above. Conclusion: Prevalence of DFU is high in this study. Establishing educational programmes to provide information to patients on peripheral neuropathy will help with poor glycaemic control and practice of foot care as well as provide a cost-effective way of preventing ulcers, amputations and even death.
SISTEM PENDUKUNG KEPUTUSAN SELEKSI KARYAWAN MENGGUNAKAN METODE SIMPLE ADDITIVE WEIGHTING PADA PT.PHILIPS SEAFOOD INDONESIA

Karyawan (sumber daya manusia / SDM) merupakan sumber daya yang sangat penting dalam perusahaan. Dalam perencanaan dan usaha untuk memenuhi kebutuhan SDM dilakukan seleksi yang dikelola secara profesional sehingga dapat menentukan mutu dan kesuksesan perusahaan. PT. Philips Seafood Indonesia merupakan perusahaan yang bergerak dalam bidang pangan yaitu crab and fish. Untuk meningkatkan produktivitasnya, perusahaan tentunya membutuhkan banyak karyawan yang berkualitas. Untuk memperoleh karyawan yang diharapkan perusahaan maka perlu dilakukan perekrutan karyawan. Dibangun sebuah sistem pengambilan keputusan dalam memilih karyawan yang sesuai kebutuhan dan kriteria perusahaan dengan menggunakan metode Simple Additive Weighting (SAW). Penelitian ini menggunakan metode SAW karena merupakan salah satu metode penyelesaian multi kriteria dimana dalam perekrutan karyawan mempunyai banyak kriteria yang harus di pertimbangkan. Kata Kunci : Sistem pendukung keputusan, Simple Weighting Additive
Identification of the Potential Correlation between Tumor Protein 73 and Head and Neck Squamous Cell Carcinoma

Background Head and neck squamous cell carcinomas (HNSC) are common malignant tumors with a high occurrence and poor prognosis. Tumor protein P73 (TP73) plays an integral role in a wide range of human malignancies, but its gene expression profile, prognostic value, and potential mechanisms in HNSC remain to be comprehensively explored. Objective This research aimed to elucidate the potential relationship between TP73 and HNSC through bioinformatics analysis. Methods The Cancer Genome Atlas (TCGA) database was queried to investigate the regulatory role of TP73 in HNSC. The survival probabilities linked to TP73 mRNA were determined via the Kaplan-Meier analysis using R packages. Subsequently, the association of TP73 with several clinical subgroups and immunological subtypes was studied using a cohort from the TCGA-HNSC. Functional analyses were used to identify the potential signaling pathways enriched by the correlated genes of TP73. The relationship between TP73 and immunological aspects, including immune cells, immune inhibitor genes, immune stimulator genes, and tumor immune microenvironment, were investigated. Results This study showed that the protein and mRNA levels of TP73 in HNSC patients were significantly higher than those in normal tissues. Elevated TP73 expression was related to a better survival outcome in HNSC patients. The TP73 gene was an independent prognostic factor for overall survival in HNSC samples. TP73 was mainly involved in DNA replication, ribosome, apoptosis, mismatch repair, and folate biosynthesis. TP73 was found to be positively correlated with the majority of tumor infiltrating immune cells and immunoinhibitory genes in HNSC. Conclusions Integrative bioinformatics and statistical analyses displayed that TP73 might serve as a novel marker for the diagnosis and prognosis of HNSC. TP73 modulates immune cells in the tumor microenvironment of HNSC patients, thereby bearing significance for HNSC immunotherapy.
Enhanced Carbonylation of Photosynthetic and Glycolytic Proteins in Antibiotic Timentin-Treated Tobacco In Vitro Shoot Culture

Antibiotics are used in plant in vitro tissue culture to eliminate microbial contamination or for selection in genetic transformation. Antibiotic timentin has a relatively low cytotoxic effect on plant tissue culture; however, it could induce an enduring growth-inhibiting effect in tobacco in vitro shoot culture that persists after tissue transfer to a medium without antibiotic. The effect is associated with an increase in oxidative stress injury in plant tissues. In this study, we assessed changes of reactive oxygen species accumulation, protein expression, and oxidative protein modification response associated with enduring timentin treatment-induced growth suppression in tobacco (Nicotiana tabacum L.) in vitro shoot culture. The study revealed a gradual 1.7 and 1.9-fold increase in superoxide (O2•−) content at the later phase of the propagation cycle for treatment control (TC) and post-antibiotic treatment (PA) shoots; however, the O2•− accumulation pattern was different. For PA shoots, the increase in O2•− concentration occurred several days earlier, resulting in 1.2 to 1.4-fold higher O2•− concentration compared to TC during the period following the first week of cultivation. Although no protein expression differences were detectable between the TC and PA shoots by two-dimensional electrophoresis, the increase in O2•− concentration in PA shoots was associated with a 1.5-fold increase in protein carbonyl modification content after one week of cultivation, and protein carbonylation analysis revealed differential modification of 26 proteoforms involved in the biological processes of photosynthesis and glycolysis. The results imply that the timentin treatment-induced oxidative stress might be implicated in nontranslational cellular redox balance regulation, accelerates the development of senescence of the shoot culture, and contributes to the shoot growth-suppressing effect of antibiotic treatment.
Convolutional Neural Network with Multiscale Fusion and Attention Mechanism for Skin Diseases Assisted Diagnosis

Melanoma segmentation based on a convolutional neural network (CNN) has recently attracted extensive attention. However, the features captured by CNN are always local that result in discontinuous feature extraction. To solve this problem, we propose a novel multiscale feature fusion network (MSFA-Net). MSFA-Net can extract feature information at different scales through a multiscale feature fusion structure (MSF) in the network and then calibrate and restore the extracted information to achieve the purpose of melanoma segmentation. Specifically, based on the popular encoder-decoder structure, we designed three functional modules, namely MSF, asymmetric skip connection structure (ASCS), and calibration decoder (Decoder). In addition, a weighted cross-entropy loss and two-stage learning rate optimization strategy are designed to train the network more effectively. Compared qualitatively and quantitatively with the representative neural network methods with encoder-decoder structure, such as U-Net, the proposed method can achieve advanced performance.
Estimating survival in a remote community-based fishery using acoustic telemetry

Small-scale fisheries are often considered data poor due to a myriad of complex factors. Precise estimates of key demographic rates are central to the sustainable management of these fisheries. We used three years of acoustic telemetry data to derive survival estimates of Greenland halibut (Reinhardtius hippoglossoides; n = 255) within a small-scale community fishery in Pangnirtung, Nunavut. Cormack-Jolly-Seber survival estimates were similar for the three top models (quarterly ϕ > 0.80) and detection probability varied with time and as a result of different tag configurations used (p Tag type+t). Survival also differed depending on the location and timing of fish tagging (ϕ Catch; summer vs. winter). A further joint analysis combining detections of live fish and returned tags, estimated quarterly survival and site fidelity probability (s = 0.97, 0.92 – 1.00 CI and f = 0.96, 0.92 – 1.00 CI, respectively). Survival estimates were unachievable using traditional tagging methods, highlighting the value of acoustic telemetry mark-recapture as a management tool for estimating demographic parameters for poorly known small-scale fisheries.
Diabetes Prediction Using Machine Learning Algorithms and Ontology

Diabetes is one of the chronic diseases, which is increasing from year to year. The problems begin when diabetes is not detected at an early phase and diagnosed properly at the appropriate time. Different machine learning techniques, as well as ontology-based ML techniques, have recently played an important role in medical science by developing an automated system that can detect diabetes patients. This paper provides a comparative study and review of the most popular machine learning techniques and ontology-based Machine Learning classification. Various types of classification algorithms were considered namely: SVM, KNN, ANN, Naive Bayes, Logistic regression, and Decision Tree. The results are evaluated based on performance metrics like Recall, Accuracy, Precision, and F-Measure that are derived from the confusion matrix. The experimental results showed that the best accuracy goes for ontology classifiers and SVM.
Embedding L2 Listening Homework in Metacognitive Intervention: Listening Comprehension Development

A review of the various approaches to L2 listening instruction suggests that they were more of text- or communication-oriented approaches and less of learner-oriented ones. More recently, the focus has shifted to engage L2 listeners in their own listening comprehension process through strategy instruction inside the classroom and strategy use outside the classroom. In this regard, Vandergrift and Goh suggested a metacognitive approach to L2 listening instruction in which listening homework is assigned to L2 listeners as an extensive listening activity. Thus, the present article reports on a qualitative study that explores the role of embedding listening homework in metacognitive intervention in the case of English as Foreign Language listening comprehension and the problems learners encounter during listening. A group of intermediate-level male and female learners (N = 25) speaking Persian as the first language participated in embedded listening tasks. As part of a metacognitive intervention, the learners were given listening homework for which they were requested to view five news programs drawn from the BBC website for 5 weeks and complete diaries with a self-directed listening guide before, during, and after watching the programs. Totally, 116 diary entries were analyzed and data about factors influencing their listening comprehension processes and the actual notes they took during planning, monitoring, and evaluating stages of listening comprehension were collected. To categorize and analyze the diary entries, Goh’s framework was used as the analytical framework. Results indicated that diaries with a self-directed listening guide served pedagogical purposes by raising the learners’ metacognitive knowledge and providing them with opportunities to plan, monitor, and evaluate their unseen listening processes. It helped listeners to reflect on their listening homework, find the gap, take action to resolve their listening problems, and experience a sense of achievement and confidence. Possible reasons for findings are outlined and recommendations for future research are presented.