Miracle-dz/UniFAR-FTUs huggingface dataset:
Framework for Increasing Eco-efficiency in the Tofu Production Process: Circular Economy Approach

Abstract This research aims to design recommendations for improving the tofu production process in Sugihmanik Village. Over 30 tofu small medium enterprises (SMEs) generate solid and liquid waste, which pollutes the river. An eco-efficiency strategy was implemented and began by identifying the tofu production process. The life cycle assessment (LCA) method and the SimaPro software were used to calculate eco-cost and eco-efficiency levels. Based on the calculations, the eco-cost value per batch is USD 10.76. If 30 batches are produced daily, the eco-cost value in one of the tofu SMEs is USD 9.10. Tofu production has an eco-efficiency index (EEI) value of 0.12. This value shows that tofu products are only affordable but have yet to be sustainable. The researchers then recommend using biogas from wastewater treatment to replace rice husks and corncobs. This study also develops a circular economy framework in the tofu production system. The output is expected to suppress the discharge of water and solid waste to increase the EEI value of the tofu production process in the future.
Between familism and neoliberalism: the case of Jewish Israeli grandmothers

In this article, we employ grandmothers’ childcare as a lens to explore the changing relations between familism, individualism and neoliberalism. More generally, we examine the connections between the political economy and the intimate moral economy of childcare work performed by grandmothers. Based on semi-structured in-depth interviews with twenty retired women in Israel, we examine how they negotiate, comply and resist the expectations that they will help ‘fill in’ the ‘care deficit’ resulting from neoliberal policies and labour market practices. We show how grandmothers navigate between family ideologies and individualistic cultural imperatives, constituting themselves as agentive subjects who can determine the conditions in which they meet their families’ care expectations while challenging the invisibility of their work. Thus, using Israel as a case study, we argue that familism and individualism, working against each other as well as together, create tensions while mediating the political economy and the intimate moral economy based on the love, commitment and ideology of the ‘good mother’. More broadly, we assert that neoliberalism strengthens family and familism and, at the same time, familism facilitates the neoliberal labour market and economy while also freeing the state from having to support families with children.
Platelet proteo-transcriptomic profiling validates mediators of thrombosis and proteostasis in patients with myeloproliferative neoplasms

Patients with chronic Myeloproliferative Neoplasms (MPN) including polycythemia vera (PV) and essential thrombocythemia (ET) exhibit unique clinical features, such as a tendency toward thrombosis and hemorrhage, and risk of disease progression to secondary bone marrow fibrosis and/or acute leukemia. Although an increase in blood cell lineage counts (quantitative features) contribute to these morbid sequelae, the significant qualitative abnormalities of myeloid cells that contribute to vascular risk are not well understood. Here, we address this critical knowledge gap via a comprehensive and untargeted profiling of the platelet proteome in a large (n= 140) cohort of patients (from two independent sites) with an established diagnosis of PV and ET (and complement prior work on the MPN platelet transcriptome from a third site). We discover distinct MPN platelet protein expression and confirm key molecular impairments associated with proteostasis and thrombosis mechanisms of potential relevance to MPN pathology. Specifically, we validate expression of high-priority candidate markers from the platelet transcriptome at the platelet proteome (e.g., calreticulin (CALR), Fc gamma receptor (FcγRIIA) and galectin-1 (LGALS1) pointing to their likely significance in the proinflammatory, prothrombotic and profibrotic phenotypes in patients with MPN. Together, our proteo-transcriptomic study identifies the peripherally-derived platelet molecular profile as a potential window into MPN pathophysiology and demonstrates the value of integrative multi-omic approaches in gaining a better understanding of the complex molecular dynamics of disease. Highlights MPN patient platelet proteome identifies key pathobiological mediators of thrombosis and proteostasis. The MPN platelet proteomic profile validates our prior findings from the platelet transcriptome.
Genetic drift and purifying selection shape within-host influenza A virus populations during natural swine infections

Patterns of within-host influenza A virus (IAV) diversity and evolution have been described in natural human infections, but these patterns remain poorly characterized in non-human hosts. Elucidating these dynamics is important to better understand IAV biology and the evolutionary processes that govern spillover into humans. Here, we sampled an IAV outbreak in pigs during a week-long county fair to characterize viral diversity and evolution in this important reservoir host. Nasal wipes were collected on a daily basis from all pigs present at the fair, yielding up to 421 samples per day. Subtyping of PCR-positive samples revealed the co-circulation of H1N1 and H3N2 subtype IAVs. PCR-positive samples with robust Ct values were deep-sequenced, yielding 506 sequenced samples from a total of 253 pigs. Based on higher-depth re-sequenced data from a subset of these initially sequenced samples (260 samples from 168 pigs), we characterized patterns of within-host IAV genetic diversity and evolution. We find that IAV genetic diversity in single-subtype infected pigs is low, with the majority of intra-host single nucleotide variants (iSNVs) present at frequencies of <10%. The ratio of the number of nonsynonymous to the number of synonymous iSNVs is significantly lower than under the neutral expectation, indicating that purifying selection shapes patterns of within-host viral diversity in swine. The dynamic turnover of iSNVs and their pronounced frequency changes further indicate that genetic drift also plays an important role in shaping IAV populations within pigs. Taken together, our results highlight similarities in patterns of IAV genetic diversity and evolution between humans and swine, including the role of stochastic processes in shaping within-host IAV dynamics.
Speciation in brooding and poorly dispersing lacustrine organisms

Understanding the origin of modern and fossil lacustrine species swarms has been problematic for evolutionary biologists. Various lines of evidence, primarily from studies of nonmarine cichlid fishes, suggest that a detailed analysis of dispersal mechanisms and brooding behavior in lacustrine organisms is critical to the solution of this problem. The results of studies of interpopulation variability in brooding and nonbrooding taxa from Lake Tanganyikan ostracodes support the hypothesis that gene flow between populations of lacustrine brooders may be greatly inhibited by extreme localization of gene pools. Significant interpopulation variability occurs among populations of the brooding ostracode Mesocythere irsacae in the absence of habitat barriers, whereas sympatric nonbrooding populations of a cytherideid ostracode, n. gen., n. sp. A show minimal variation over the same range. Extreme genetic isolation may cause rapid speciation and extinction in such populations, owing to the vagaries of small population sizes. Lacustrine environments tend to be geologically ephemeral and efficient dispersal is important for continual recolonization of appropriate habitats. When a lake persists for geologically long periods of time, however, selective pressures for excellent dispersal mechanisms may relax. Under such circumstances, clades of lacustrine brooding organisms, which are often poor dispersers, would radiate and suffer extinctions at accelerated rates.
Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Helicobacter Eradication for Lesion Prevention.

BACKGROUND The effect of Helicobacter pylori in patients receiving non-steroidal anti-inflammatory drugs (NSAIDs) is unclear. We investigated the effects of H. pylori eradication in patients with current or previous peptic ulceration, dyspepsia, or both who continued to use NSAIDs. METHODS 285 patients were randomly assigned omeprazole 20 mg, amoxycillin 1000 mg, and clarithromycin 500 mg, twice daily (n=142, H. pylori eradication treatment), or omeprazole with placebo antibiotics (n=143, controls) for 1 week. All patients received omeprazole 20 mg once daily for 3 weeks until endoscopy, and, if the ulcer was not healed, 40 mg once daily until repeat endoscopy at 8 weeks. Ulcer-free patients with mild dyspepsia continued NSAIDs but not antiulcer treatment. We investigated ulcers with endoscopy at 1, 3, and 6 months and with carbon-13-labelled urea breath test at 3 months. FINDINGS The estimated probability of being ulcer-free at 6 months was 0.56 (95% CI 0.47-0.65) on eradication treatment and 0.53 (0.44-0.62) on on control treatment (p=0.80). Time to treatment failure did not differ between groups for ulcers or dyspepsia alone, per-protocol analysis, or final H. pylori status. 66% (58-74) of the eradication group compared with 14% (8-20) of the control group had a final negative H. pylori result (p<0.001). Fewer baseline gastric ulcers healed among eradication-treatment patients than among controls (72 vs 100% at 8 weeks, p=0.006). INTERPRETATION H. pylori eradication in long-term users of NSAIDs with past or current peptic ulcer or troublesome dyspepsia led to impaired healing of gastric ulcers and did not affect the rate of peptic ulcers or dyspepsia over 6 months.
English Teacher Behavior And Students’ Academic Achievement At Secondary Level

Teachers play a great role in students’ success. Role of their practices and behavior cannot be detached from students’ achievement. Exploration of association of various aspects of teachers’ behaviors with students’ achievement may provide useful guidelines to enhance their achievement which is a major determinant of their career and future success. Therefore, this study was carried out with the aim to find the associations of teacher’s instructional, socio-emotional, and organizational behavior with academic achievement of students. For this purpose, tenth grade students from government secondary schools in the districts of Punjab were considered the population of the study. From these schools,1526 students were selected as sample using random sampling technique. Student reported teacher behavior scale was used for data collection and students’ academic achievement scores were obtained from their schools. Correlations were determined in the various aspects of teacher’s behavior and students’ academic achievement. It was found that students’ academic achievement was significantly positively associated with all the aspects of teacher’s behavior. The results of both genders were significantly found associated with students’ academic achievement in the subject of English. It was concluded that along with the instructional behavior of teachers their socio-emotional and organizational behavior played role in students’ academic achievements. It was therefore recommended that teachers must consider their socio-emotional and organizational behavior along with the instructional behavior in the classroom as these were significantly associated with students’ achievements. Students also need to be conscious about their views related to teacher behavior as these were positively associated with their academic achievements.
Climatology of Snow Depth and Water Equivalent measurements in the Italian Alps (1967 - 2020)

A climatology of SWE based on data collected at 299 gauging sites was performed for the Italian Alps over the 1967 – 2020 period, when the Italian National Electric board conducted routinely and with homogeneous methods snow depth and density measurements. Six hydrological sub-regions were investigated spanning from the eastern Alps to the 10 western Alps at altitudes ranging from 1000 m to 3000 m asl. Measures were conducted at fixed dates at the beginning of each month from 1 February to 1 June and on 15 April. To our knowledge this is the most comprehensive and homogeneous dataset of measured snow depth and density for the Italian Alps. Significant decreasing trends over the years at fixed dates and elevation classes were identified for both snow depth (-0.12 m decade -1 on average) and snow water equivalent (-37 mm decade -1 on average) in most of the six investigated areas. The analysis of bulk snow density data showed a temporal 15 evolution along the snow accumulation and melt season, but no altitudinal trends were found. A Moving Average and Running Trend Analysis (MARTA triangles), combined with a Pettitt’s test change-point detection, highlighted a decreasing change of snow climatology occurring around the end of the 1980s. Correlation with climatic indexes indicate significant negative values of Pearson correlation coefficient with winter North Atlantic Oscillation (NAO) and positive values with winter West Mediterrean oscillation (WeMO) for some areas and elevation classes. Results of this climatology are 20 synthesized in a temporal polynomial model useful for climatological studies and water resources management in mountain areas.
A Review on Polycystic Ovarian Syndrome in Relation to Insulin Resistance Pathogenesis

: Polycystic ovary syndrome PCOS is considered a multifactorial disorder with various genetic, metabolic, endocrine and environmental abnormalities. In women with PCOS, insulin resistance (IR) is very common which is also related to obesity and weight gain. A literature survey was done using different search engines and databases such as and Google Scholar, PUBMED, NCBI to prepare a narrative review on this topic. PCOS is a most common endocrine disorder prevailing in reproductive age women across the world. The current review has highlighted the role of insulin resistance in the development and the pathogenesis of the disease. Hyperinsulinemia and hyperandrogenemia are two principle factors of PCOS and their cause and effect is still vague. Based on the various data, a positive correlation was also observed between oxidative stress and insulin resistance.
Effect of Girdling and Foliar Spraying of Potassium and Cobalamin on Growth, Yield and Fruit Quality of Crimson Seedless Grapevines

: The current investigation was carried out for two consecutive seasons (2021 and 2022) in a private vineyard located at Matay center, Minia governorate, Egypt to improve the vegetative growth aspects, vine nutritional status, yield and fruit quality attributes of Crimson Seedless by girdling and foliar spraying of potassium and cobalamin. The chosen vines were nine-year old, grown in sandy soil, irrigated under drip irrigation system, spaced at 2X3 meters apart and trellised by Gable system. The vines were cane-pruned during the last week of January with maintain a load of 72 buds/vine (6 canes X 12 buds). Eight treatments were performed as follows; trunk girdling, foliar spraying of potassium at 1% and foliar spraying of cobalamin at 300ppm were applied either solely or in combination among them, in addition to the control treatment (untreated vines). Girdling was applied after fruit set stage when the berry diameter reaches 2-3 mm, while both potassium and cobalamin were foliar sprayed three times; the 1 date (after bud burst stage), the 2 date (at fruit set stage) st
Serum calprotectin correlates with risk and disease severity in psoriasis patients and the decrease of calprotectin predicts better response to tumor necrosis factor inhibitors.

OBJECTIVE This study aimed to investigate the correlation of serum calprotectin expression with risk and severity of psoriasis, as well as its predictive value for clinical response to tumor necrosis factor inhibitors (TNFi) treatment in psoriasis patients. PATIENTS AND METHODS 72 psoriasis patients and 70 health controls (HCs) were enrolled. Blood samples were collected, and serum calprotectin was determined by commercial enzyme-linked immuno sorbent assay (ELISA). All patients were treated by TNFi treatment, and followed up at 6 months, and the last follow-up date was 2016/11. RESULTS Calprotectin level was elevated in psoriasis patients compared to HCs (p < 0.001), and it disclosed a good diagnostic value of psoriasis with area under curve (AUC) 0.872, 95% CI: 0.810-0.935. Calprotectin expression was positively associated with Psoriasis Area and Severity Index (PASI) score (R = 0.452, p < 0.001), while it was not associated with BSA (R = 0.125, p = 0.297). 58.3% patients achieved PASI75 and 43.1% patients achieved PASI90 at M6. Calprotectin was decreased during the 6-month treatment (p < 0.001). Changes of calprotectin during the first month (∆calprotectin (M0-M1)) in PASI75 group were more than that of non-PASI75 group (p < 0.001). Also, multivariate logistic analysis revealed that ∆calprotectin (M0-M1) (p = 0.001) was an independent factor for PASI75 achievement at M6 after TNFi treatment, while pre-systemic biologic treatment (p = 0.001) was an independent factor for non-PASI75 achievement. CONCLUSIONS Serum calprotectin expression is correlated with risk and severity of psoriasis, and the decrease of calprotectin during the first month could predict better clinical response to TNFi treatment in psoriasis patients.
Thiamethoxam Induced Oxidative Stress and Histopathological Alterations in Male Patients

Thiamethoxam is one of the second-generation neonicotinoids, a new class of insecticides. The study was designed to investigate the effect of thiamethoxam on fertility in bucks. For this purpose, sixteen male adult male chinchilla rabbits were divided in two groups. Thiamethoxam intoxicated group was treated with thiamethoxam at dose of 250 mg/Kg body weight for 3 months. Semen analysis revealed distinct changes in sperm characteristics including significant decrease in sperm motility (both mass and individual) and sperm count. In addition, significant increase in dead spermatozoa and sperm deformities. Moreover, elevation in testicular concentration of MDA and GST was significant. GSH was significantly decreased. Degeneration and necrosis of spermatogenic cells with intertubular edema and vacuolations in seminiferous tubules were the major observed histopathological changes in the testis of intoxicated animals. In conclusion, thiamethoxam administration for 3 months induced significant decrease in fertility and oxidative stress in the reproductive system of adult male.
Evaluation of different grape (Vitis sp.) rootstocks for North Indian conditions

: Viticulture in North India is suffering from different problems, of which termite and salinity are the major causes for decline of vineyards. This is mainly due to extensive use of the self-rooted plant materials. Therefore, it is now felt that viticulture in the region should include rootstock based composite plants so that the vineyard life is more and the plants can endure biotic and abiotic stresses more efficiently. Keeping this point in view, an experiment was conducted to evaluate the different grape rootstock genotypes for their suitability as potential rootstocks for the different scion cultivars. The performance of ten rootstocks viz. , Dogridge A, Dogridge B, Salt Creek, 1613, 1616, St. George, SO4, 1103 P, Teleki 5A and H-144 were evaluated on the basis of different vegetative growth parameters such as total shoot length, shoot growth rate, total number of leaves/sprout, leaf characters and root characters. The rootstocks, Dogridge A, Salt Creek and 1613 performed better in comparison to others tried for different parameters. The final survival of different grape rootstocks under nursery conditions was the maximum in Salt Creek followed by 1613 and Dogridge A.
Predictive role of admission serum glucose, baseline NIHSS score, and fibrinogen on hemorrhagic transformation after intravenous thrombolysis with alteplase in acute ischemic stroke.

OBJECTIVE This study aimed to investigate the predictive role of admission serum glucose, baseline NIHSS score, and fibrinogen on hemorrhagic transformation after intravenous thrombolysis with alteplase in acute ischemic stroke. PATIENTS AND METHODS A total of 254 patients admitted with acute ischemic stroke who received intravenous thrombolysis with alteplase from January 2016 to December 2017 were selected to collect clinical data. Patients were divided into a hemorrhagic transformation group (n=70) and a no-hemorrhagic transformation group (n=184) based on repeat CT/magnetic resonance imaging (MRI) findings during the acute period. The demographic data, past medical history and laboratory examination indexes of the two groups were compared. Multivariate Logistic regression analysis was used to explore the influencing factors of hemorrhage transformation after intravenous thrombolysis in patients with acute ischemic stroke. ROC curve was used to plot the ability of blood glucose at admission, baseline NIHSS score and fibrinogen alone to predict bleeding transformation after intravenous thrombolysis of alteplase, and then the combined model of the three was constructed and the predictive ability of this model to bleeding transformation was evaluated. RESULTS Among 254 patients, 70% (27.55%) had hemorrhage transformation. Except for DNT, red blood cell count, platelet count, fibrinogen, smoking, atrial fibrillation, baseline NIHSS score and admission serum glucose, there were statistically significant differences between the hemorrhagic transformation group and the non-hemorrhagic transformation group (p<0.05), and there were no statistically significant differences in other indicators between the two groups (p>0.05). The combined model was better than the three models alone in predicting the risk of bleeding conversion (p<0.05). Compared with the group without hemorrhagic transformation, the 90d prognosis was worse in the hemorrhage transformation group (p<0.05). CONCLUSIONS Admission blood glucose, NIHSS score, and fibrinogen are independent risk factors for hemorrhage transformation after intravenous thrombolysis of alteplase in patients with acute ischemic stroke, and the combined model established by them has high predictive efficacy for hemorrhage transformation risk after intravenous thrombolysis of alteplase.