Miracle-dz/UniFAR-FTUs huggingface dataset:
PHYSICS OF NON-GAUSSIAN FIELDS AND THE COSMOLOGICAL GENUS STATISTIC

We report a technique to calculate the impact of distinct physical processes inducing non-Gaussianity on the cosmological density field. A natural decomposition of the cosmic genus statistic into an orthogonal polynomial sequence allows complete expression of the scale-dependent evolution of the topology of large-scale structure, in which effects including galaxy bias, nonlinear gravitational evolution, and primordial non-Gaussianity may be delineated. The relationship of this decomposition to previous methods for analyzing the genus statistic is briefly considered and the following applications are made: (1) the expression of certain systematics affecting topological measurements, (2) the quantification of broad deformations from Gaussianity that appear in the genus statistic as measured in the Horizon Run simulation, and (3) the study of the evolution of the genus curve for simulations with primordial non-Gaussianity. These advances improve the treatment of flux-limited galaxy catalogs for use with this measurement and further the use of the genus statistic as a tool for exploring non-Gaussianity.
A VERY DEEP CHANDRA OBSERVATION OF THE GALAXY GROUP NGC 5813: AGN SHOCKS, FEEDBACK, AND OUTBURST HISTORY

We present results from a very deep (650 ks) Chandra X-ray observation of the galaxy group NGC 5813, the deepest Chandra observation of a galaxy group to date. This system uniquely shows three pairs of collinear cavities, with each pair associated with an unambiguous active galactic nucleus (AGN) outburst shock front. The implied mean kinetic power is roughly the same for each outburst, demonstrating that the average AGN kinetic luminosity can remain stable over long timescales (∼50 Myr). The two older outbursts have larger, roughly equal total energies as compared with the youngest outburst, implying that the youngest outburst is ongoing. We find that the gas radiative cooling rate and mean shock heating rate are well balanced at each shock front, suggesting that shock heating alone is sufficient to offset cooling and establish AGN/intracluster medium (ICM) feedback within at least the central 30 kpc. This heating takes place roughly isotropically and most strongly at small radii, as is required for feedback to operate. We suggest that shock heating may play a significant role in AGN feedback at smaller radii in other systems, where weak shocks are more difficult to detect. We find non-zero shock front widths that are too large to be explained by particle diffusion. Instead, all measured widths are consistent with shock broadening due to propagation through a turbulent ICM with a mean turbulent speed of ∼70 km s−1. Finally, we place lower limits on the temperature of any volume-filling thermal gas within the cavities that would balance the internal cavity pressure with the external ICM.
ON THE RADIO AND NEAR-INFRARED JET OF PKS 2155−304 AND ITS CLOSE ENVIRONMENT

PKS 2155−304 is one of the brightest BL Lac objects in the sky and a very well-studied target from radio to TeV bands. We report on high-resolution (∼0.″12) direct imaging of the field of PKS 2155−304 using adaptive optics near-IR (NIR) observations in the J and Ks bands obtained with the ESO Multi-Conjugate Adaptive Optics Demonstrator on the Very Large Telescope. These data are complemented with archival Very Large Array images at various frequencies to investigate the properties of the close environment of the source. We characterize the faint galaxies that form the poor group associated with the target. No radio emission is present for these galaxies, while an old radio jet at ∼20 kpc from the nucleus of PKS 2155−304 and a jet-like structure of ∼2 kpc (∼1″) in the eastern direction are revealed. No counterparts of these radio jets are found in the NIR or in archival Chandra observations.
Music and Speech Perception in Prelingually Deafened Young Listeners With Cochlear Implants: A Preliminary Study Using Sung Speech.

PURPOSE In the context of music and speech perception, this study aimed to assess the effect of variation in one of two auditory attributes-pitch contour and timbre-on the perception of the other in prelingually deafened young cochlear implant (CI) users, and the relationship between pitch contour perception and two cognitive functions of interest. METHOD Nine prelingually deafened CI users, aged 8.75-22.17 years, completed a melodic contour identification (MCI) task using stimuli of piano notes or sung speech with a fixed timbre (same word for each note) or a mixed timbre (different words for each note), a speech perception task identifying matrix-styled sentences naturally intonated or sung with a fixed pitch (same pitch for each word) or a mixed pitch (different pitches for each word), a forward digit span test indexing auditory short-term memory (STM), and the matrices section of the Kaufman Brief Intelligence Test-Second Edition indexing nonverbal IQ. RESULTS MCI was significantly poorer for the mixed timbre condition. Speech perception was significantly poorer for the fixed and mixed pitch conditions than for the naturally intonated condition. Auditory STM positively correlated with MCI at 2- and 3-semitone note spacings. Relative to their normal-hearing peers from a related study using the same stimuli and tasks, the CI participants showed comparable MCI at 2- or 3-semitone note spacing, and a comparable level of significant decrement in speech perception across three pitch contour conditions. CONCLUSION Findings suggest that prelingually deafened CI users show similar trends of normal-hearing peers for the effect of variation in pitch contour or timbre on the perception of the other, and that cognitive functions may underlie these outcomes to some extent, at least for the perception of pitch contour. SUPPLEMENTAL MATERIAL https://doi.org/10.23641/asha.21217937.
Depression and anxiety in individuals with axial spondyloarthritis and nonspecific low back pain who are interested in non-pharmacological therapy options: Cross-sectional study

Psychological burden, such as depression and anxiety, may be associated with axial spondyloarthritis (axSpA) and poor prognosis of nonspecific low back pain (NSLBP). Non-pharmacological therapy is a substantial part of the management of both illnesses. Our study describes the psychological outcomes in patients with axSpA and NSLBP who were actively looking for non-pharmacological therapy. A total of 60 participants (34 with axSpA and 26 with NSLBP) were included in this cross-sectional study. Anxiety and depression were examined using the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI-II), respectively. The relationships between BAI and BDI-II and quality of life (EQ-5D), pain intensity (NRS pain), disease activity (AS disease activity score, ASDAS-CRP), and function (Bath AS Functional Index, BASFI) were determined. The intensity of anxiety and depression did not differ between patients with and without axSpA. In both, axSpA and NSLBP, BAI, and BDI-II scores were inversely correlated with EQ-5D, R = −0.268 (P ˂ .05) and R = −0.486 (P ˂ .0001), respectively. We found a variation in the relationship between pain intensity and psychological outcomes in NSLBP and axSpA. The pain intensity score was correlated with the BDI-II (R = 0.542, P = .001) and BAI (R = 0.489, P = .003) scores only in patients with axSpA. In patients with axSpA, BAI was inversely correlated with disease duration (R = −0.356, P = .039) and positively correlated with increased disease activity and poor function, ASDAS-CRP (R = 0.431, P = .012) and BASFI (R = 0.621, P ˂ .0001) scores. The ASDAS-CRP score was positively correlated with BDI-II (R = 0.562, P = .001), and both disease activity and female sex were identified as risk factors for poor BDI-II outcomes in axSpA patients according to multiple regression analysis. Experiences of anxiety and depression seem to be similar for patients with axSpA and NSLBP in this selected group of participants. However, pain intensity may influence psychological outcomes, mainly in patients with axSpA. Disease activity, impaired function, and female sex were risk factors for anxiety and depression in patients with axSpA.
The relationship between fibromyalgia and depression, anxiety, anxiety sensitivity, fear avoidance beliefs, and quality of life in female patients

The study aims to determine whether there is a relationship between fibromyalgia (FM) disease and depression, anxiety, anxiety sensitivity, fear-avoidance beliefs, and quality of life in female patients with a diagnosis of fibromyalgia. 37 female patients followed up with FM diagnosis in pain medicine clinic and a control group consisting of 37 healthy women were included in the study. Sociodemographic and Clinical Characteristics Data Form, Quality of Life Form, fear-avoidance beliefs questionnaire, Anxiety Sensitivity Index-3, Beck Anxiety Inventory, Beck Depression Inventory, and Visual Analogue Scale was applied to the participants. When the patients in the FM group were compared to the control group; Statistically lower scores in all Quality of Life Form subscales except emotional role difficulty and social functionality scores; statistically higher scores in both physical and work activity subscales in fear-avoidance beliefs questionnaire; statistically higher scores in cognitive symptoms subscale in Anxiety Sensitivity Index-3, Beck Anxiety Inventory, Beck Depression Inventory, and Visual Analogue Scale scores were found. In FM patients, it has been determined that anxiety, depression and perceived pain severity reduce social functionality and quality of life in areas such as mental health, physical function, and emotional role difficulties. It was determined that the functionality and quality of life of patients diagnosed with FM decreased in daily life. An important contribution of the study to the literature is that it shows that the behavior of avoiding activity due to pain-induced fear exacerbates the pain and even contributes to its chronicity. These results, which show the effects of anxiety, depression, anxiety sensitivity, and fear-avoidance behavior on the prognosis of the disease in FM patients, indicate that psychiatric evaluation and treatment in FM patients is an important factor that determines the functionality and quality of life.
(Eye-)tracking the escape from the self: guilt proneness moderates the effect of failure on self-avoidance

ABSTRACT Failure increases the motivation to escape self-awareness. To date, however, the role of self-conscious emotions (shame and guilt) in triggering escape responses after failure has not been sufficiently addressed. In this pre-registered study (N = 156 undergraduates), we adapted a classic paradigm (avoidance of one’s image in a mirror) to a modern eye-tracking technology to test the hypothesis that shame proneness moderates the effect of failure on self-awareness avoidance. Individual differences in guilt and shame proneness were assessed before priming thoughts of failure or success. Then, an eye-tracking paradigm was used to monitor gaze avoidance of one’s screen-reflected face during a neutral, unrelated task. Unexpectedly, results showed that guilt but not shame proneness exacerbated self-avoidance after failure. The present findings challenge the dominant view that shame fosters avoidance more so than guilt.
Five-Factor Model Personality Traits and the Trajectory of Episodic Memory: Individual-Participant Meta-analysis of 471,821 Memory Assessments from 120,640 Participants.

OBJECTIVES Five-factor model (FFM) personality traits are associated with concurrent memory function and risk of incident dementia but are less consistently associated with change in episodic memory. The present research analyzes multiple large-scale studies with a consistent analytic approach to evaluate the association between personality and change in episodic memory over time. METHOD Across 9 public longitudinal datasets, 120,640 participants provided 471,821 memory assessments over up to 26 years (age range 18-108). FFM traits were tested as predictors of the average level (intercept) and change over time (slope) of episodic memory. Results from the individual samples were meta-analyzed to summarize the associations. RESULTS Consistent with expectations for the intercept, higher neuroticism was associated with worse memory performance, whereas higher openness and conscientiousness were associated with better performance; extraversion and agreeableness were also associated with better performance. Higher neuroticism and lower conscientiousness were related to declines in memory only in samples with more than two assessments of memory. The other three traits were unrelated to memory slope. The pattern was similar when participants with dementia were excluded from the analysis, and the association with the slope was not moderated by age. DISCUSSION FFM traits have a robust association with average memory performance. Higher neuroticism and lower conscientiousness were associated with declines in memory performance only among samples with more than two memory assessments. The heterogeneity across studies suggests that multiple memory assessments are needed to reliably detect change over time, which may be one reason for past inconsistencies across studies.
Tac-Trainer: A Visual Analytics System for IoT-based Racket Sports Training

Conventional racket sports training highly relies on coaches' knowledge and experience, leading to biases in the guidance. To solve this problem, smart wearable devices based on Internet of Things technology (IoT) have been extensively investigated to support data-driven training. Considerable studies introduced methods to extract valuable information from the sensor data collected by IoT devices. However, the information cannot provide actionable insights for coaches due to the large data volume and high data dimensions. We proposed an IoT + VA framework, Tac-Trainer, to integrate the sensor data, the information, and coaches' knowledge to facilitate racket sports training. Tac-Trainer consists of four components: device configuration, data interpretation, training optimization, and result visualization. These components collect trainees' kinematic data through IoT devices, transform the data into attributes and indicators, generate training suggestions, and provide an interactive visualization interface for exploration, respectively. We further discuss new research opportunities and challenges inspired by our work from two perspectives, VA for IoT and IoT for VA.
Target formation in muscle fibres indicates reinnervation – A proteomic study in muscle samples from peripheral neuropathies

Target skeletal muscle fibres – defined by different concentric areas in oxidative enzyme staining – can occur in patients with neurogenic muscular atrophy. Here, we used our established hypothesis‐free proteomic approach with the aim of deciphering the protein composition of targets. We also searched for potential novel interactions between target proteins.
Accelerated post-AGB evolution, initial-final mass relations, and the star-formation history of the Galactic bulge ,

Aims. We study the star-formation history of the Galactic bulge, as derived from the age distribution of the central stars of planetary nebulae that belong to this stellar population. Methods. The high resolution imaging and spectroscopic observations of 31 compact planetary nebulae are used to derive their central star masses. We use the Blocker post asymptotic giant branch (post-AGB) evolutionary models, which are accelerated by a factor of three in this case to better fit the white dwarf mass distribution and asteroseismological masses. Initial-final mass relations (IFMR) are derived using white dwarfs in clusters. These are applied to determine original stellar masses and ages. The age distribution is corrected for observational bias as a function of stellar mass. We predict that there are about 2000 planetary nebulae in the bulge. Results. The planetary nebula population points at a young bulge population with an extended star-formation history. The Blocker tracks with the cluster IFMR result in ages, which are unexpectedly young. We find that the Blocker post-AGB tracks need to be accelerated by a factor of three to fit the local white dwarf masses. This acceleration extends the age distribution. We adjust the IFMR as a free parameter to map the central star ages on the full age range of bulge stellar populations. This fit requires a steeper IFMR than the cluster relation. We find a star-formation rate in the Galactic bulge, which is approximately constant between 3 and 10 Gyr ago. The result indicates that planetary nebulae are mainly associated with the younger and more metal-rich bulge populations. Conclusions. The constant rate of star-formation between 3 and 10 Gyr agrees with suggestions that the metal-rich component of the bulge is formed during an extended process, such as a bar interaction.
Effect of mineral oil as a lubricant to collect feces from cats for microbiome studies

Abstract Background Fecal specimens are critical for disease screening, diagnosis, and gut microbiome research. For domestic cats, lubricants are often necessary to obtain a sufficient quantity of sample. However, the effect of lubrication on feline microbiome analysis has not been assessed. Objectives To evaluate if lubrication using mineral oil during cat feces sample collection affects the DNA extraction, metagenomic sequencing yield, and the microbial composition and diversity in subsequent gut microbiome analyses. Animals Eight 6‐year‐old male, neutered, domestic short‐haired cats housed in a research facility. Methods Cohort study. The gut microbiomes were investigated for fecal sample collection with and without lubrication using whole‐genome shotgun metagenomic sequencing. Results Fecal specimens were collected using a fecal loop under sedation without lubrication and with mineral oil lubrication. There were no significant differences between the 2 groups in the microbial DNA yield in ng/mg fecal sample (75.75 [25.8‐125.7] vs 60.72 [33.49‐87.95], P = .95), metagenomic sequencing yield in Gbp (10.31 [6.29‐14.32] vs 13.53 [12.04‐15.02], P = .2), proportion of host contamination (0.1 [0.02‐0.18] vs 0.15 [0‐0.3], P = .84), relative taxonomy abundance (P > .8), or the number of microbial genes covered (408 132 [341 556‐474 708] vs 425 697 [358 505‐492 889], P = .31). Conclusions and Clinical Importance Fecal sampling with mineral oil lubrication did not change the microbial DNA extraction yield, metagenomic sequencing yield, level of host contamination, the microbial composition and diversity in subsequent gut microbiome analyses. Here we reported a proven cat‐friendly protocol for fecal sample collection in clinical and research setting for gut microbiome analyses.
Constraining the halo mass function with observations

The abundances of dark matter halos in the universe are described by the halo mass function (HMF). It enters most cosmological analyses and parametrizes how the linear growth of primordial perturbations is connected to these abundances. Interestingly, this connection can be made approximately cosmology independent. This made it possible to map in detail its near-universal behavior through large-scale simulations. However, such simulations may suffer from systematic effects, especially if baryonic physics is included. In this paper we ask how well observations can constrain directly the HMF. The observables we consider are galaxy cluster number counts, galaxy cluster power spectrum and lensing of type Ia supernovae. Our results show that DES is capable of putting the first meaningful constraints on the HMF, while both Euclid and J-PAS can give stronger constraints, comparable to the ones from state-of-the-art simulations. We also find that an independent measurement of cluster masses is even more important for measuring the HMF than for constraining the cosmological parameters, and can vastly improve the determination of the halo mass function. Measuring the HMF could thus be used to cross-check simulations and their implementation of baryon physics. It could even, if deviations cannot be accounted for, hint at new physics.
Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti‐diazepam‐induced ataxia action as a structure‐dependent feature

Several pyrazoloquinolinone (PQ) ligands were recently discovered as functionally selective positive modulators at the PQ site of α6‐containing GABAA receptors. PQs are also neutral modulators at the benzodiazepine site. We assessed the influence of PQ compounds from three structural groups (PZ‐II‐029 and related deuterated analogues DK‐I‐56‐1, RV‐I‐029, DK‐I‐60‐3 and DK‐I‐86‐1; LAU 463 and related analogues DK‐I‐58‐1 and DK‐II‐58‐1; and DK‐I‐87‐1), alone and in combination with diazepam, on the behaviour of male Sprague–Dawley rats. An excellent behavioural safety profile of all tested PQs was demonstrated in the spontaneous locomotor activity, rotarod, loss of righting reflex and pentylenetetrazol tests. In interaction studies, only PZ‐II‐029 and its analogues prevented the ataxic effects of the benzodiazepine, as assessed in the rotarod test and during monitoring of rat locomotor activity after awakening from the loss of righting reflex. Published electrophysiological profiles of PQ ligands imply that positive modulation elicited at α6‐GABAA receptors that contain the γ2 and δ subunit, rather than their neutral modulatory action at the benzodiazepine site, may prevent the ataxic action of diazepam. Thus, PZ‐II‐029 and its deuterated analogues are not prone to untoward interactions with benzodiazepines and may indeed completely abolish their ataxic action, seen at therapeutic, and especially toxic concentrations.
The first INTEGRAL-OMC catalogue of optically variable sources

The Optical Monitoring Camera (OMC) onboard INTEGRAL provides photometry in the Johnson V-band. With an aperture of 50 mm and a field of view of 5deg x 5deg, OMC is able to detect optical sources brighter than V~18, from a previously selected list of potential targets of interest. After more than nine years of observations, the OMC database contains light curves for more than 70000 sources (with more than 50 photometric points each). The objectives of this work have been to characterize the potential variability of the objects monitored by OMC, to identify periodic sources and to compute their periods, taking advantage of the stability and long monitoring time of the OMC. To detect potential variability, we have performed a chi-squared test, finding 5263 variable sources out of an initial sample of 6071 objects with good photometric quality and more than 300 data points each. We have studied the periodicity of these sources using a method based on the phase dispersion minimization technique, optimized to handle light curves with very different shapes.In this first catalogue of variable sources observed by OMC, we provide for each object the median of the visual magnitude, the magnitude at maximum and minimum brightness in the light curve during the window of observations, the period, when found, as well as the complete intrinsic and period-folded light curves, together with some additional ancillary data.