Miracle-dz/UniFAR-FTUs huggingface dataset:
Nickel oxide nanoparticles induce genotoxicity and cellular alterations in the ground beetle Blaps polycresta (Coleoptera: Tenebrionidae)

Nickel nanoparticles (Ni-NPs) have advantageous applications in the industry; however, little is known of their adverse effects on biological tissues. In the present study, the ground beetle Blaps polycresta was employed as a sensitive indicator for nickel oxide nanoparticles (NiO-NPs) toxicity. Adult male beetles were injected with six dose levels of NiO-NPs (0.01, 0.02, 0.03, 0.04, 0.05, and 0.06 mg/g body weight). Mortality was reported daily over 30 days under laboratory conditions to establish an LD50. Nickel was detected in the testicular tissues of the beetles using X-ray analysis and transmission electronic microscopy. Beetles treated with the sublethal dose of 0.02 mg/g were selected to observe molecular, cellular, and subcellular changes. Gene transcripts of HSP70, HSP90, and MT1 were found to be increased >2.5-, 1.5-, and 2-fold, respectively, in the treated group compared with the controls. Decreased gene expression of AcPC01, AcPC02, and AcPC04 (≤1.5-, ≤2-, and < 2.5-fold, respectively, vs. controls) also were reported in the treated group. Under light microscopy, various structural changes were observed in the testicular tissues of the treated beetles. Ultrastructure observations using scanning and transmission electron microscopy showed severe damage to the subcellular organelles as well as deformities of the heads and flagella of the spermatozoa. Therefore, the present study postulated the impact of NiO-NPs in an ecological model.
European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force—Second revision

To revise the 2010 consensus guideline on chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Seventeen disease experts, a patient representative, and two Cochrane methodologists constructed 12 Population/Intervention/Comparison/Outcome (PICO) questions regarding diagnosis and treatment to guide the literature search. Data were extracted and summarized in GRADE summary of findings (for treatment PICOs) or evidence tables (for diagnostic PICOs). Statements were prepared according to the GRADE Evidence‐to‐Decision frameworks. Typical CIDP and CIDP variants were distinguished. The previous term “atypical CIDP” was replaced by “CIDP variants” because these are well characterized entities (multifocal, focal, distal, motor, or sensory CIDP). The levels of diagnostic certainty were reduced from three (definite, probable, possible CIDP) to only two (CIDP and possible CIDP), because the diagnostic accuracy of criteria for probable and definite CIDP did not significantly differ. Good Practice Points were formulated for supportive criteria and investigations to be considered to diagnose CIDP. The principal treatment recommendations were: (a) intravenous immunoglobulin (IVIg) or corticosteroids are strongly recommended as initial treatment in typical CIDP and CIDP variants; (b) plasma exchange is strongly recommended if IVIg and corticosteroids are ineffective; (c) IVIg should be considered as first‐line treatment in motor CIDP (Good Practice Point); (d) for maintenance treatment, IVIg, subcutaneous immunoglobulin or corticosteroids are recommended; (e) if the maintenance dose of any of these is high, consider either combination treatments or adding an immunosuppressant or immunomodulatory drug (Good Practice Point); and (f) if pain is present, consider drugs against neuropathic pain and multidisciplinary management (Good Practice Point).
Obesity is not associated with disease‐free interval, melanoma‐specific survival, or overall survival in patients with clinical stage IB‐II melanoma after SLNB

Clinicopathologic characteristics have prognostic value in clinical stage IB‐II patients with melanoma. Little is known about the prognostic value of obesity that has been associated with an increased risk for several cancer types and worsened prognosis after diagnosis. This study aims to examine effects of obesity on outcome in patients with clinical stage IB‐II melanoma.
Examining the Effectiveness of Public Involvement from the Beginning Stage of Railway Projects to Improve Accessibility in Japan - Based on a Satisfaction Survey on Accessibility Achieved in Three Best Practices from the 1990s to the 2010s -

In this paper, we examined and confirmed the effectiveness of public involvement in improving accessibility in three selected railway projects. These are the Hankyu-Itami Station project, Fukuoka Nanakuma Subway project, and Sendai Tozai Subway project. As we had already previously analyzed the approaches and processes of the three projects through stakeholder interviews and literature reviews, we next carried out a satisfaction survey to collect passengers' voices, including both persons with and without mobility difficulties. Through the survey, we found that passengers with mobility difficulties benefit more from accessible facilities that have been planned via public involvement. We also found that accessible facilities continue to provide barrier-free and universal design access over time. Judging from our findings, we support the view that public involvement is an effective approach to improving satisfaction in the usability of barrier-free and universal design facilities.
Willingness to Get a COVID-19 Vaccine and Reasons for Hesitancy Among Medicare Beneficiaries: Results From a National Survey

Objectives: To assess (1) the willingness to get a COVID-19 vaccine among Medicare beneficiaries, (2) the associated factors, and (3) the reasons for vaccine hesitancy. Methods: Data were taken from the Medicare Current Beneficiary Survey (MCBS) 2020 Fall COVID-19 Supplement, conducted October-November 2020. Willingness to get a COVID-19 vaccine was measured by respondents' answer to whether they would get a COVID-19 vaccine when available. We classified responses of “definitely” and “probably” as “willing to get,” and responses “probably not,” “definitely not,” and “not sure” as “vaccine hesitancy. ” Reasons for vaccine hesitancy were assessed by a series of yes/no questions focusing on 10 potential reasons. The analytical sample included 6715 adults 65 years and older. We conducted a logistic regression model to assess demographic factors and other factors associated with the willingness to get a COVID-19 vaccine. All analyses were conducted in Stata 14 and accounted for the complex survey design of MCBS. Results: Overall, 61.0% (95% confidence interval [CI], 59.1-63.0) of Medicare beneficiaries would be willing to get a vaccine when available. Among those who were hesitant, more than 40% reported that mistrust of the government and side effects as the main reasons. Logistic regression model results showed that non-Hispanic Blacks (adjusted odds ratio [AOR] = 0.33; 95% CI, 0.24-0.44) and Hispanics (AOR = 0.60; 95% CI, 0.47-0.77) were less willing to get a vaccine than non-Hispanic Whites; beneficiaries with an income of less than $25 000 (AOR = 0.71; 95% CI, 0.62-0.81) were less willing to get the vaccine than those with an income of $25 000 or more; those who did not think that the COVID-19 virus was more contagious (AOR = 0.53; 95% CI, 0.41-0.69) or more deadly (AOR = 0.51; 95% CI, 0.41-0.65) were also less willing to get the vaccine than those who thought that the virus was more contagious or more deadly than the influenza virus. Conclusions: The 2020 MCBS survey data showed that close to 40% of Medicare beneficiaries were hesitant about getting a COVID-19 vaccine, and the hesitancy was greater in racial/ethnic minorities. Medicare beneficiaries were concerned about the safety of the vaccine, and some appeared to be misinformed. Evidence-based educational and policy-level interventions need to be implemented to further promote COVID-19 vaccination.
Evaluation of toxicity, mutagenicity, metabolism and formation of 2-dodecylcyclobutanone in irradiated ground beef

The effect of fat level and antioxidant Origanox on the formation of 2dodecylcylobutanone (2-DCB) was investigated in fresh irradiated ground beef patties. Patties containing 15% and 25 % fat were irradiated by electron beam at 1, 2, 3, and 4.5 kGy. Ground beef patties with 0.08% Origanox were gamma irradiated at 3.0 kGy. Commercially available irradiated ground beef with different fat levels was analyzed in order to estimate dose absorbed by these samples. The 2-DCB was extracted by Supercritical fluid extraction (SFE) and analyzed by gas chromatography-mass spectrometry (GC-MS). The concentration of 2-DCB increased linearly with dose with no significant difference in 2-DCB concentrations between the two fat levels. The estimated doses applied to the commercial samples ranged between 1.38 kGy and 1.55 kGy. Origanox did not affect the concentration of 2-DCB. Mutagenicity of 2-DCB was evaluated by the Ames assay using five standard Salmonella tester strains with S9 enzyme activation. The Ames assay did not show a mutagenic effect of 2DCB, including samples incubated with S9. Acute toxicity of 2-DCB was evaluated by the Microtox acute toxicity system and compared with cyclohexanone and 2-nonenal (both GRAS additives). The toxicity of 2-DCB was between that of cyclohexanone and 2-nonenal while the maximum toxic effect elicited by 2-DCB was the least of the three compounds. Metabolism of 2-DCB was investigated in Female Sprague-Dawley rats. Hexane extracts of feces and fat were analyzed by GC-MS. Urine with and without added $-glucuronidase, was monitored for glucuronide complexes by hexane extraction GC-MS. The total amount of 2-DCB recovered in feces was 1.78 ± 0.63 mg over five days, about 3-11% of the total 2-DCB administered. The total amount recovered in fat was 0.08 ± 0.01 mg which was approximately 0.33% of the total 2-DCB administered. No metabolites were recovered in any of the urine extracts. EVALUATION OF TOXICITY, MUTAGENICITY, METABOLISM AND FORMATION OF 2-DODECYLCYCLOBUTANONE IN IRRADIATED GROUND BEEF
The Roles of General Health and COVID-19 Proximity in Contact Tracing App Usage: Cross-sectional Survey Study

Background Contact tracing apps are considered useful means to monitor SARS-CoV-2 infections during the off-peak stages of the COVID-19 pandemic. Their effectiveness is, however, dependent on the uptake of such COVID-19 apps. Objective We examined the role of individuals’ general health status in their willingness to use a COVID-19 tracing app as well as the roles of socioeconomic characteristics and COVID-19 proximity. Methods We drew data from the WageIndicator Foundation Living and Working in Coronavirus Times survey. The survey collected data on labor market status as well as the potential confounders of the relationship between general health and COVID-19 tracing app usage, such as sociodemographics and regular smartphone usage data. The survey also contained information that allowed us to examine the role of COVID-19 proximity, such as whether an individual has contracted SARS-CoV-2, whether an individual has family members and colleagues with COVID-19, and whether an individual exhibits COVID-19 pandemic–induced depressive and anxiety symptoms. We selected data that were collected in Spain, Italy, Germany, and the Netherlands from individuals aged between 18 and 70 years (N=4504). Logistic regressions were used to measure individuals’ willingness to use a COVID-19 tracing app. Results We found that the influence that socioeconomic factors have on COVID-19 tracing app usage varied dramatically between the four countries, although individuals experiencing forms of not being employed (ie, recent job loss and inactivity) consistently had a lower willingness to use a contact tracing app (effect size: 24.6%) compared to that of employees (effect size: 33.4%; P<.001). Among the selected COVID-19 proximity indicators, having a close family member with SARS-CoV-2 infection was associated with higher contact tracing app usage (effect size: 36.3% vs 27.1%; P<.001). After accounting for these proximity factors and the country-based variations therein, we found that having a poorer general health status was significantly associated with a much higher likelihood of contact tracing app usage; compared to a self-reported “very good” health status (estimated probability of contact tracing app use: 29.6%), the “good” (estimated probability: +4.6%; 95% CI 1.2%-8.1%) and “fair or bad” (estimated probability: +6.3%; 95% CI 2.3%-10.3%) health statuses were associated with a markedly higher willingness to use a COVID-19 tracing app. Conclusions Current public health policies aim to promote the use of smartphone-based contact tracing apps during the off-peak periods of the COVID-19 pandemic. Campaigns that emphasize the health benefits of COVID-19 tracing apps may contribute the most to the uptake of such apps. Public health campaigns that rely on digital platforms would also benefit from seriously considering the country-specific distribution of privacy concerns.
Early post‐operative nausea and vomiting: A retrospective observational study of 2030 patients

The overall risk of post‐operative nausea and vomiting (PONV) after general anaesthesia is reportedly 20%–40%. The first episode of PONV may occur early in the post‐anaesthesia care unit (PACU) or later at the ward or after discharge at home in an ambulatory setting. This study aimed to investigate and describe the risk of early PONV in a PACU, and we hypothesised that patients and perioperative factors were associated with early PONV.
Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine

Intron retention (IR) is an important regulatory mechanism that affects gene expression and protein functions. Using klotho mice at the pre-symptomatic state, we discovered that retained-introns accumulated in several organs including the liver and that among these retained introns in the liver a subset was recovered to the normal state by a Japanese traditional herbal medicine. This is the first report of IR recovery by a medicine. IR-recovered genes fell into two categories: those involved in liver-specific metabolism and in splicing. Metabolome analysis of the liver showed that the klotho mice were under starvation stress. In addition, our differentially expressed gene analysis showed that liver metabolism was actually recovered by the herbal medicine at the transcriptional level. By analogy with the widespread accumulation of intron-retained pre-mRNAs induced by heat shock stress, we propose a model in which retained-introns in klotho mice were induced by an aging stress and in which this medicine-related IR recovery is indicative of the actual recovery of liver-specific metabolic function to the healthy state. Accumulation of retained-introns was also observed at the pre-symptomatic state of aging in wild-type mice and may be an excellent marker for this state in general.
Intent to get vaccinated against COVID-19 among reproductive-aged women in Texas

ABSTRACT Data are needed on the acceptability of Covid-19 vaccination among young, low-income, diverse populations. To assess this, we surveyed 18–45-year-old women on their intent to be vaccinated, experiences with Covid-19, and uptake of other vaccines. Among the 342 who completed the survey, only one-third were likely to accept the Covid-19 vaccine as soon as it was available. Less than half would accept it even if recommended by their doctor. Most (69%) wanted more information on its safety and 48% wanted proof it works. Likelihood of accepting the vaccine with a doctor’s recommendation was associated with fear of catching Covid-19 and exposure to social media as well as HPV and annual flu vaccination. This demonstrates it will be necessary to help vaccine-hesitant individuals overcome their concerns to reach herd immunity in the US. Physician recommendation and social media may play important roles.
People with weight‐related long‐term conditions want support from GPs: A qualitative interview study

Two‐thirds of UK adults do not have an up‐to‐date weight record in primary care. Some studies suggest that doctors do not raise the topic of weight management for fear of causing embarrassment or offence, or are doubtful whether people will make changes. However, for people with weight‐related long‐term conditions, conversations with general practitioners (GPs) can be crucial. Our study explores how people with long‐term conditions associated with overweight recall and interpret conversations about weight in British primary care. An experienced qualitative researcher interviewed 41 people aged <42 years with long‐term conditions associated with overweight. A maximum variation sample was sought, and transcribed interviews were analysed thematically. We revealed that patients with weight‐related long‐term conditions have different experiences and expectations about the role of GPs in supporting weight management. If a GP did not raise weight management in the context of the long‐term condition patients formed the impression that their overweight was not seen as “doctorable” that is, as an appropriate topic for the consultation, rather than a personal or “lifestyle” concern. This was explained in multiple ways, which are captured in two themes; perceiving weight as “doctorable”; and weight doctoring in primary care. The findings highlight the need for increased attention on weight‐related long‐term conditions in primary care. Interventions from GPs would be welcome if conducted in a sensitive, non‐judgmental manner and based on sound evidence about what works.
Theory analysis of social justice in nursing: Applications to obstetric violence research

The dual purpose of this article is to present a formal theory analysis combined with recommendations for the use of social justice in nursing as a framework for the study of obstetric violence in US hospitals. A theory analysis of emancipatory nursing praxis as a middle-range theory of social justice in nursing was conducted using the strategy by Walker and Avant. The theory of social justice in nursing was determined to be logical, useful, and generalizable. The soundness and usability of the theory support the recommendations made for it to be applied to the study of obstetric violence, plus quality and outcome problems in maternity care that have been resistant to sustained progress and may benefit from a new paradigm for continued study. The alignment for obstetric violence to be studied with a social justice framework is linked to the theory’s origins in critical social theory and the evolving concept of obstetric violence as a sex-specific form of violence against women that is a violation of human rights. The postmodern expansion of the body of work based on critical theory provides examples from emancipatory and feminist researchers for recognizing how the study of obstetric violence is compatible with a theoretical framework for social justice in nursing. The suitability of this framework to guide the further research needed to better understand, identify, and minimize harms from the occurrence of obstetric violence is argued. In addition, “The Code” for the American Nurses Association (ANA) is cited as a professional reference that outlines nurses’ responsibilities for practice based on ethics, human rights, and social justice that are antithetical to the occurrence of obstetric violence.
Efficient extra‐mitochondrial aerobic ATP synthesis in neuronal membrane systems

The nervous system displays high energy consumption, apparently not fulfilled by mitochondria, which are underrepresented therein. The oxidative phosphorylation (OxPhos) activity, a mitochondrial process that aerobically provides ATP, has also been reported also in the myelin sheath and the rod outer segment (OS) disks. Thus, commonalities and differences between the extra‐mitochondrial and mitochondrial aerobic metabolism were evaluated in bovine isolated myelin (IM), rod OS, and mitochondria‐enriched fractions (MIT). The subcellular fraction quality and the absence of contamination fractions have been estimated by western blot analysis. Oxygen consumption and ATP synthesis were stimulated by conventional (pyruvate + malate or succinate) and unconventional (NADH) substrates, observing that oxygen consumption and ATP synthesis by IM and rod OS are more efficient than by MIT, in the presence of both kinds of respiratory substrates. Mitochondria did not utilize NADH as a respiring substrate. When ATP synthesis by either sample was assayed in the presence of 10–100 µM ATP in the assay medium, only in IM and OS it was not inhibited, suggesting that the ATP exportation by the mitochondria is limited by extravesicular ATP concentration. Interestingly, IM and OS but not mitochondria appear able to synthesize ATP at a later time with respect to exposure to respiratory substrates, supporting the hypothesis that the proton gradient produced by the electron transport chain is buffered by membrane phospholipids. The putative transfer mode of the OxPhos molecular machinery from mitochondria to the extra‐mitochondrial structures is also discussed, opening new perspectives in the field of neurophysiology.
Exploring Circular economy in the hospitality industry: empirical evidence from Scandinavian hotel operators

ABSTRACT The circular economy is gaining momentum in corporate circles and European economic policies. However, its relevance and applicability to service dominated industries, such as tourism and hospitality, is poorly researched. This study investigates Scandinavian hotel operators’ understanding of the circular economy, its drivers, enablers, barriers, and value creation potential. This exploratory study gathers feedback from ten Scandinavian hotel chains managers and proposes a circular economy applicability framework to test the concept’s relevance to hotel operators. The research findings highlight respondents’ interest and expose introductory to intermediate level of understanding of the circular economy. Conditional to specific enabling levers, the research confirms the applicability and value creation potential of the circular economy to hotel operators. The research provides hotel operators with recommendations on circular economy value creation opportunities, deployment pathways and suggests future research directions.
Genuine Liking or the Need for Closure? The Differential Effects of Consumers’ TV Drama Viewing Motivations on Commercial Viewership

ABSTRACT Television advertising effectiveness constitutes a key marketing issue. Advertisers rely on program TV ratings to determine advertisement placement because consumers’ decisions to view TV commercials are largely influenced by their TV program-viewing behavior. However, high program viewership of television dramas does not always entail high commercial viewership; consumers’ motivations for drama consumption play a critical role. In the context of TV drama viewing, we build a two-stage structural model that distinguishes two motivations for TV drama consumption—viewers’ liking for a drama and the need for cognitive closure—and demonstrate their contrasting effects on consumers’ commercial-viewing behavior. Although both motivations enhance drama-viewing behavior, consumers exhibit an enhanced (vs. diminished) tendency to watch subsequent commercials when they possess heightened liking for the drama (vs. the need for cognitive closure). These findings contribute to extant research on TV commercial-viewing behavior by distinguishing the roles of different drama-viewing motivations. Based on the model estimation results, we conduct a series of simulation studies to generate rich managerial implications. Managerial practices for both advertisers and TV networks are discussed.