Miracle-dz/UniFAR-FTUs huggingface dataset:
Dislocation self-organization processes and crystal plasticity

The theoretical treatment of the evolution of a dislocation ensemble in a plastically deformed real crystal is discussed. Kinetic equations for the dislocation density are formulated which include elementary dislocation processes (source generation, immobilization, multiplication, annihilation, and diffusion) and on the basis of which the first three stages of the crystal's strain-hardening curves are quantitatively analyzed. Dislocation self-organization processes leading to slip localization and various nonuniform dislocation structures are considered. Mechanisms of the formation of slip lines, slip bands, defect-free (annihilation) channels in neutron-irradiated or quenched crystals, and dislocation cellular structures are discussed in detail based on the equations obtained. A comparison of theoretical results with experimental data is made.
Reliability and clinical utility of spatially constrained estimates of intrinsic functional networks from very short fMRI scans

Resting‐state functional network connectivity (rsFNC) has shown utility for identifying characteristic functional brain patterns in individuals with psychiatric and mood disorders, providing a promising avenue for biomarker development. However, several factors have precluded widespread clinical adoption of rsFNC diagnostics, namely a lack of standardized approaches for capturing comparable and reproducible imaging markers across individuals, as well as the disagreement on the amount of data required to robustly detect intrinsic connectivity networks (ICNs) and diagnostically relevant patterns of rsFNC at the individual subject level. Recently, spatially constrained independent component analysis (scICA) has been proposed as an automated method for extracting ICNs standardized to a chosen network template while still preserving individual variation. Leveraging the scICA methodology, which solves the former challenge of standardized neuroimaging markers, we investigate the latter challenge of identifying a minimally sufficient data length for clinical applications of resting‐state fMRI (rsfMRI). Using a dataset containing rsfMRI scans of individuals with schizophrenia and controls (M = 310) as well as simulated rsfMRI, we evaluated the robustness of ICN and rsFNC estimates at both the subject‐ and group‐level, as well as the performance of diagnostic classification, with respect to the length of the rsfMRI time course. We found individual estimates of ICNs and rsFNC from the full‐length (5 min) reference time course were sufficiently approximated with just 3–3.5 min of data (r = 0.85, 0.88, respectively), and significant differences in group‐average rsFNC could be sufficiently approximated with even less data, just 2 min (r = 0.86). These results from the shorter clinical data were largely consistent with the results from validation experiments using longer time series from both simulated (30 min) and real‐world (14 min) datasets, in which estimates of subject‐level FNC were reliably estimated with 3–5 min of data. Moreover, in the real‐world data we found rsFNC and ICN estimates generated across the full range of data lengths (0.5–14 min) more reliably matched those generated from the first 5 min of scan time than those generated from the last 5 min, suggesting increased influence of “late scan” noise factors such as fatigue or drowsiness may limit the reliability of FNC from data collected after 10+ min of scan time, further supporting the notion of shorter scans. Lastly, a diagnostic classification model trained on just 2 min of data retained 97%–98% classification accuracy relative to that of the full‐length reference model. Our results suggest that, when decomposed with scICA, rsfMRI scans of just 2–5 min show good clinical utility without significant loss of individual FNC information of longer scan lengths.
HIGH-RESOLUTION LABORATORY MEASUREMENTS OF CORONAL LINES IN THE 198–218 Å REGION

We present high-resolution laboratory measurements of the emission from various ions of C, N, O, F, Ne, S, Ar, Fe, and Ni in the extreme ultraviolet wavelength band centered around the λ211 Fe xiv channel of the Atmospheric Imaging Assembly on the Solar Dynamics Observatory. While all of the strong iron lines in this region are well known, we note many weaker lines of iron that are not yet identified. The high resolution of our measurements also allows us to resolve several lines in Fe xi, Fe xii, and Fe xiii between 200 and 205 Å, whose identities were in question based on a disagreement between different databases. The spectra of the elements other than iron are much less known, and we find a multitude of lines that are not yet in the databases. For example, the CHIANTI database clearly disagrees with the NIST data listings on several of the argon lines we observe and also it contains only about half of the observed sulfur lines.
The X-Ray Telescope onboard Suzaku

We present the design parameters, production process, and in-flight performance of the X-ray telescopes (XRTs) onboard Suzaku. The imaging capability is significantly improved over the ASCA XRT, which had half-power diameters of 3. 0 6, to 1. 0 8–2. 0 3 for all four XRT-I modules. The optical axes are found to be distributed within a radius of 1. 3, which makes the observation efficiency of all the XRTs more than 97% at the XIS-default observing position. The vignetting over the XIS field of view predicted via ray-tracing coincides with that measured for observations of the Crab Nebula to within »10%. Contemporaneous fits of a power law to all the XIS spectra of the Crab Nebula taken at the two standard observing positions (XIS/HXDdefault positions) gives a flux consistent with that obtained by Toor & Seward (1974) to within »2%. The pre-collimator on the top of each XRT module successfully re
Systematic review of ethical issues in perinatal mental health research

Background Maternal mental health during the peripartum period is critically important to the wellbeing of mothers and their infants. Numerous studies and clinical trials have focused on various aspects of interventions and treatments for perinatal mental health from the perspective of researchers and medical health professionals. However, less is known about women’s experiences of participating in perinatal mental health research, and the ethical issues that arise. Aim To systematically review the literature on the ethical issues that emerge from pregnant and/or postpartum women’s experiences of taking part in perinatal mental health-related research. Methods Systematic review of nine bibliographic databases, from inception to July 2021. Qualitative, quantitative and mixed method studies were included if they reported on ethical issues experienced by perinatal women. Research ethical issues encompassed any issue relating to women’s experiences of being offered study information, recruitment, consent, retention and respect for autonomy. Titles, abstracts and full text screening, appraisal of the methodological quality of included studies, and data extraction, were conducted independently by two reviewers. Ethical considerations Ethical approval was not required for this systematic review. Findings A total of 9830 unique citations was retrieved. Six studies met the inclusion criteria. Studies were clinically and methodologically heterogenous, and only one was purposively designed to explore women’s experiences. The key finding was the establishment of trust between the researcher and participant in all stages of the research process. Findings are presented according to recruitment and consent processes, participation and retention, and study follow-up and completion. Conclusion The establishment of trust between the researcher and perinatal women leads to a dynamic with research ethical implications relevant to all stages of perinatal mental health-related research. Further research on the research ethical issues experienced by perinatal women is required because of the limited literature.
Digital lamellar inflammatory signaling in an experimental model of equine preferential weight bearing

Abstract Background Supporting limb laminitis (SLL) is a complication of severe orthopedic disease in horses and is often life‐limiting, yet the pathophysiology remains obscure. Hypothesis/Objectives To investigate the role of digital lamellar inflammatory signaling in the pathophysiology of SLL using a model of unilateral weight bearing, hypothesizing that there would be evidence of lamellar inflammation in limbs subjected to the model. Animals Thirteen healthy adult Standardbred horses were used for this study (11 geldings, 2 mares; mean age 6.5 ± 2.5 years; mean body weight 458.3 ± 32.8 kg). Methods Randomized controlled experimental study. A steel shoe with a custom insert was applied to a randomly selected front foot of 7 horses; 6 horses were unshod and served as controls. After 92 hours, all horses were humanely euthanized, and digital lamellar samples were collected. Lamellar protein and mRNA were isolated and used to perform western blot and PCR. Results Lamellar concentrations of IL‐6 mRNA were higher in SL tissue than IL HIND tissue (median [25%‐75%] normalized copy number 191 [111‐3060] and 48 [25‐74], respectively; P=.003), and lamellar concentrations of COX‐2 mRNA were higher in SL tissue than CON tissue (normalized copy number 400 [168‐634] and 125 [74‐178], respectively; P=.007). Lamellar concentrations of IL‐1B, IL‐10, and COX‐1 mRNA were not significantly different between groups. The concentrations of phosphorylated (activated) STAT1 and STAT3 proteins were higher in SL (0.5 [0.35‐0.87] and 1.35 [1.1‐1.7], respectively) compared to CON (0.24 [0.09‐0.37] and 0.31 [0.16‐037]) and UL HIND (0.27 [0.19‐0.37] and 0.38 [0.24‐0.5]); P=0.01 and P<0.001. Conclusions and Clinical Importance Lamellar inflammatory signaling was higher in tissue from horses subjected to prolonged unilateral weight‐bearing, suggesting that these pathways could be relevant to the pathophysiology of SLL.
Biofabricated copper ferrite nanoparticles: a potential nanosorbent for the removal of Pb (II) ions from aqueous media

In the present study, we describe a facile strategy for the easy removal of the heavy metal ion, Pb (II) using biosynthesized copper ferrite (CuFe2O4) Nanoparticles (Nps) prepared via a cost-effective and eco-friendly method using Pimenta dioica leaf extract. The structural characterization was performed using UV–Visible, FT-IR, XRD, XPS, TG, SEM - EDS and TEM techniques. Various characterization techniques showed that the biosynthesized CuFe2O4 nanoparticles have spherical shape with minimum aggregation and possess a size range between 7 and 16 nm. Batch experiments were carried out to analyze the adsorption efficiency of CuFe2O4 Nps by varying different experimental conditions such as pH, adsorbent dose and initial metal ion concentration. From the atomic absorption spectroscopy results, the optimum removal efficiency (99.69%) occurred at a contact time of 90 min in the solution having pH 6 with 0.06 g of nanoadsorbent. The experimental data were analyzed using adsorption isotherm and fitted with kinetic models. In the present study, we report the the highest removal efficiency of 99.69% for Pb (II) ions with minimum experimental parameters which is greater than other similar reported studies. The novel CuFe2O4 nanosorbent synthesized in the present study is highly effective in eliminating toxic pollutants. They also possess outstanding recycling characteristics for the effective removal of Pb (II) ions from aqueous media.This cost-effective and ecofriendly strategy could be utilized for addressing the emerging water contamination.
Positioning of psychodynamic psychotherapy in the treatment of depression: A comparison of the RANZCP 2020 and NICE 2022 guidelines

Objective To compare the 2022 NICE guidelines (NG222) and 2020 RANZCP clinical practice guidelines (MDcpg2020) recommendations for the treatment of depression using psychodynamic psychotherapy. Conclusions Both guidelines recommend psychological interventions first-line. However, only short-term psychodynamic psychotherapy (STPP) is recommended, and in the NG222 it is ranked last for less severe depression and 7th for more severe depression. In contrast, cognitive behavioural therapy and behavioural activation are deemed the more clinically effective and cost-effective psychological therapies. And antidepressants play a significant role – largely in more severe depression.
Feline litter box issues associate with cat personality, breed, and age at sterilization.

OBJECTIVE To identify potential risk factors for feline litter box issues (eg, house soiling). ANIMALS 3,049 privately owned cats. PROCEDURES Data were collected using a validated, owner-completed survey with convenience sampling. The feline behavior and personality survey included 138 statements related to cat behavior and questions concerning cat background and health. Statements related to litter box issues were subjected to factor analysis. Associations between the identified factors and personality and background variables were studied using generalized linear models. Strength of these associations (ie, importance) was evaluated by calculating relative and absolute effect sizes. RESULTS Factor analysis yielded 2 factors: house soiling and litter box fussiness. This study suggests that fearful cats are more prone to both forms of litter box issues than nonfearful individuals. Other associations we found differed between factors. For example, low sociability toward cats, male sex, and being intact associated only with increased house soiling and older age only with litter box fussiness. The most important variables in the litter box models (ie, sociability toward cats, breed, and activity/playfulness) failed to reach the suggested cutoff for a small effect size. CLINICAL RELEVANCE Numerous variables are thought to influence litter box issues, but few studies have examined their relevance. Here, we studied the associations of over 30 background variables and personality traits with 2 litter box issue factors to estimate their importance at the population level. Our results bring new knowledge to this field and may contribute to finding new solutions for these complex issues in the future.
Recreational Drug Use and Distress From Hallucinations in the General Dutch Population.

BACKGROUND AND HYPOTHESIS Distress associated with auditory (AH) and visual (VH) hallucinations in the general population was found to be predictive of later need for mental healthcare. It is, therefore, important to understand factors relating to the distress individuals experience from their hallucinations. Hallucinations can easily occur under substance-induced states, but recreational drug use is also known as a self-medication strategy. The current study, therefore, investigated whether recreational drug use by individuals from the general population is associated with the degree of distress experienced from AH and/or VH. STUDY DESIGN Drug use and distress severity associated with AH (N = 3.041) and/or VH (N = 2.218) were assessed by means of an online survey in the general Dutch population (>14 years of age). STUDY RESULTS Multiple linear regression revealed that while past month consumption of alcohol was associated with less AH- and VH-related distress, past month cannabis use was associated with more AH- and VH-related distress. Furthermore, past month use of nitrous oxide was associated with more severe VH-related distress. CONCLUSION Recreational use of alcohol, cannabis, and nitrous oxide may play important differential roles in the degree of distress associated with AH and VH in individuals from the general population. The consumption of these substances could form a potential risk factor for the development of distressing hallucinations or function as a signal marker for their occurrence. Due to the cross-sectional design of the current study, the causal relation between recreational drug use and distressing hallucinations remains to be elucidated.
Hsp70, in Combination with IL-15 and PD-1 Blocker, Interferes with The Induction of Cytotoxic NK Cells in Relapsed Acute Myeloid Leukemia Patients

Objective: Natural killer (NK) cells are critical immune cells for acute myeloid leukemia (AML) targeting. However, little is known about the relationship between using checkpoint inhibitors and heat shock protein 70 (Hsp70) as NK cell activators to control AML. Therefore, the study aims to find the best formulation of Hsp70, human PD-1 (Programmed cell death protein 1) blocker, and interleukin 15 (IL-15) to activate NK cells against AML. Materials and Methods: In this experimental study, the NK cells were isolated from mononuclear cells (MNCs) by using magnetic activation cell sorting (MACS) and were activated using the different combinations of Hsp70, PD-1 blocker, and IL-15 and then followed by immunophenotyping, functional assays to estimate their killing potential, and evaluation of expression pattern of PRF1, PIK3CB, PD-1, AKT-1, FAS-L, TRAIL, and GER A and B. Results: The expression of PD-1 was significantly (P<0.05) reduced after NK cell activation by the different formulas of IL-15, Hsp70, and PD-1 blocker. The expression of NKG2A in the treated NK cells was reduced particularly in the IL-15 (P<0.01) and IL-15+PD-1 blocker (P<0.05) groups. The addition of Hsp70 increased its expression. The cytotoxic effect of NK cells increased in all groups, especially in IL-15+PD-1 blocker besides increasing interferon-gamma (IFN-γ), Granzymes, and perforin expression (P<0.05). All IL-15+PD-1 blocker group changes were associated with the upregulation of PIK3CB and AKT-1 as key factors of NK cell activation. The presence of Hsp70 reduced IFN-γ releasing, and down-regulation of PIK3CB, AKT-1, Granzymes, and Perforin (P<0.05). Conclusion: We suggested the combination of IL-15 and PD-1 blocker could enhance the killing potential of AMLNK cells. Moreover, Hsp70 in combination with IL-15 and PD-1 blocker interferes activation of AML-NK cells through unknown mechanisms.
Pulmonary Congestion on Lung Ultrasound Predicts Increased Risk of 30‐Day Readmission in Heart Failure Patients

Heart failure exacerbations are a common cause of hospitalizations with a high readmission rate. There are few validated predictors of readmission after treatment for acute decompensated heart failure (ADHF). Lung ultrasound (LUS) is sensitive and specific in the assessment of pulmonary congestion; however, it is not frequently utilized to assess for congestion before discharge. This study assessed the association between number of B‐lines, on LUS, at patient discharge and risk of 30‐day readmission in patients hospitalized for acute decompensated heart failure (ADHF).
Early intervention in myelofibrosis and impact on outcomes: A pooled analysis of the COMFORT‐I and COMFORT‐II studies

In a pooled analysis of the phase 3 Controlled Myelofibrosis Study With Oral JAK Inhibitor Treatment I (COMFORT‐I) and COMFORT‐II clinical trials, adult patients with intermediate‐2 or high‐risk myelofibrosis who received oral ruxolitinib at randomization or after crossover from placebo or best available therapy (BAT) had improved overall survival (OS).
Metabolic interaction between biflavonoids in Ginkgo biloba leaves and tacrolimus

The aim of this study was to investigate the effect of biflavonoids in Ginkgo biloba leaves on tacrolimus metabolism. First, the inhibitory effects of five main biflavonoids (amentoflavone, sciadopitysin, ginkgetin, isoginkgetin, bilobetin) in G. biloba leaves on tacrolimus metabolism were investigated in vitro in human liver microsomes (HLM), and the concentration‐dependent inhibition was further calculated. Then the time‐dependent inhibition activities of five biflavonoids were studied and the drug interaction was studied in Sprague–Dawley (SD) rats. Finally, the molecular mechanism of inhibition was explored by molecular docking. The results of in vitro incubation in HLM showed tacrolimus metabolism was strongly inhibited by amentoflavone, ginkgetin, and bilobetin, whose IC50 value was 5.57, 3.16, and 5.03 μM, respectively. The time‐dependent inhibition of the three above biflavonoids at 50 μM was 33.47%–50.89%. In the in vivo study in rats, the AUC0−t and Cmax of tacrolimus increased 3.8‐fold and 2.5‐fold after oral preadministration with amentoflavone. The molecular docking results showed that the inhibitory effect may be related to the formation of hydrogen bonds. The results showed that long‐term combination of G. biloba leaves and tacrolimus may cause drug–drug interactions. This study provided theoretical and experimental basis for rational drug use in clinical practice.
Ultrafast All-Optical Refractive Index Modulation in Intersubband Transition Switch Using InGaAs/AlAs/AlAsSb Quantum Well

Large, very fast phase modulation was observed in transverse electric (TE) probe light when an intersubband transition (ISBT) switch module using an InGaAs/AlAs/AlAsSb quantum well was pumped by transverse magnetic (TM) light. The phase shift amounted to 1.88 rad for a pump pulse energy of 4 pJ (fiber input), with very fast response. This phenomenon is explained by the change in plasma dispersion caused by the redistribution of electrons among subbands having different effective masses. This phase modulation will enable us to realize various novel ultrafast all-optical devices for signal processing.
Geometric and electronic diversity of metal doped boron clusters

Being intermediate between small compounds and bulk materials, nanoparticles possess unique properties different from those of atoms, molecules, and bulk matter. In the past two decades, a combination of cluster structure prediction algorithms and experimental spectroscopy techniques was successfully used for exploration of the ground-state structures of pure and metal-doped boron clusters. The fruitfulness of this dual approach is well illustrated by the discovery of intriguing microstructures and unique physicochemical properties such as aromaticity and bond fluxionality for both boron and metal-doped boron clusters. Our review starts with an overview of geometrical configurations of pure boron clusters B n , which are presented by planar, nanotube, bilayer, fullerene-like and core–shell structures, in a wide range of n values. We consider next recent advances in studies of boron clusters doped with metal atoms paying close and thoughtful attention to modifications of geometric and electronic structures of pure boron clusters by heteroatoms. Finally, we discuss the possibility of constructing boron-based nanomaterials with specific functions from metal-boron clusters. Despite a variety of fruitful results obtained in numerous studies of boron clusters, the exploration of boron-based chemistry has not yet reached its peak. The intensive research continues in this area, and it should be expected that it brings exciting discoveries of intriguing new structures.
Effect of chain conformation in the phonon transport across a Si-polyethylene single-molecule covalent junction

We use nonequilibrium molecular dynamics simulations to study heat transfer across molecular junctions formed by alkane chains covalently bonded to crystalline silicon leads. We focus our studies on the role of chain conformation on phonon transport across junctions and along the chain. We find that in the case of straight chains, all trans conformations, the silicon-polyethylene junction conductance is 180 pW/K, and heat flows ballistically, i.e. with no resistance, along the chain. The introduction of gauche conformations (kinks) leads to a nonzero thermal resistance of the chain and also reduces the junction conductance to 100 pW/K. The chain thermal resistance is proportional to the number of gauche conformations indicating that they act as strong and independent phonon scattering centers. We attribute the 80% enhancement in junction conductance during extension from coiled to straight chain conformation to ballistic (coherent) phonon transport along a straight chain.