Miracle-dz/UniFAR-FTUs huggingface dataset:
A MD Simulation Prediction for Regulation of N-Terminal Modification on Binding of CD47 to CD172a in a Force-Dependent Manner

Cancer cells can evade immune surveillance through binding of its transmembrane receptor CD47 to CD172a on myeloid cells. CD47 is recognized as a promising immune checkpoint for cancer immunotherapy inhibiting macrophage phagocytosis. N-terminal post-translated modification (PTM) via glutaminyl cyclase is a landmark event in CD47 function maturation, but the molecular mechanism underlying the mechano-chemical regulation of the modification on CD47/CD172a remains unclear. Here, we performed so-called “ramp-clamp” steered molecular dynamics (SMD) simulations, and found that the N-terminal PTM enhanced interaction of CD172a with CD47 by inducing a dynamics-driven contraction of the binding pocket of the bound CD172a, an additional constraint on CYS15 on CD47 significantly improved the tensile strength of the complex with or without PTM, and a catch bond phenomenon would occur in complex dissociation under tensile force of 25 pN in a PTM-independent manner too. The residues GLN52 and SER66 on CD172a reinforced the H-bonding with their partners on CD47 in responding to PTM, while ARG69 on CD172 with its partner on CD47 might be crucial in the structural stability of the complex. This work might serve as molecular basis for the PTM-induced function improvement of CD47, should be helpful for deeply understanding CD47-relevant immune response and cancer development, and provides a novel insight in developing of new strategies of immunotherapy targeting this molecule interaction.
A Novel Unresolved Peaks Analysis Algorithm for ME Signal Detection Based on Improved SMA

Microchip electrophoresis (ME) is an ion detection system with low cost and portability, which is suitable for online analysis of environmental samples. However, the unresolved peaks in the detection signal of complex samples seriously affect the measurement accuracy of sample concentration. In this article, an efficient unresolved peaks analysis algorithm is proposed, which is based on the sigmoidal membership function, Lévy flight, and slime mould algorithm (SLSMA). First, the hyperbolic tangent function in the original slime mould algorithm (SMA) is replaced by the sigmoidal membership function to enhance the global optimization capability. Second, we use the Lévy flight sequences to further enhance the convergence speed of the SMA algorithm. Then, the performance of SLSMA is tested using synthetic peaks with different resolutions and noise levels. Finally, ME peaks are used to further validate the application of the proposed algorithm. The results show that the proposed algorithm has higher computational efficiency and can be used for the analysis of ME peaks.
Eddy processes in momentum transport andd kinetic energy distribution

Meridional fluxes of angular momentum and kinetic energy values have been computed for the month of January 1964 between the 500 and 100-mb levels and between 30 0 N and 70 0 N for five longitudinal sectors of the Northern Hemisphere. Numerical values of these quantities are presented for combination$ of barotropic. baroclinic. standing. transient. mean meridional and eddy flux processes. Comparison of these data with radioactive fallout events supports the results from earlier case studies. The computational methods outlined here may be applied to other regions of the atmosphere in which vertical and horizontal gradients of atmospheric properties (such as ozone) reveal a marked time variation and are in a significant way transported by synopticscale three -dimensional eddies.
Non-standard insensitivity

The paper takes a closer look at some insensitivity results which are not contained in the class of insensitive generalised semi-Markov schemes. Based on a study of a special insensitive queue, a conjecture is proposed which covers all known results on insensitive equilibrium distributions. When insensitive events are also included, a study of the G/G/1 queue shows that the conjecture does not always hold.
Efficacy and Security of Tetrodotoxin in the Treatment of Cancer-Related Pain: Systematic Review and Meta-Analysis

The pharmacological treatment of cancer-related pain is unsatisfactory. Tetrodotoxin (TTX) has shown analgesia in preclinical models and clinical trials, but its clinical efficacy and safety have not been quantified. For this reason, our aim was to perform a systematic review and meta-analysis of the clinical evidence that was available. A systematic literature search was conducted in four electronic databases (Medline, Web of Science, Scopus, and ClinicalTrials.gov) up to 1 March 2023 in order to identify published clinical studies evaluating the efficacy and security of TTX in patients with cancer-related pain, including chemotherapy-induced neuropathic pain. Five articles were selected, three of which were randomized controlled trials (RCTs). The number of responders to the primary outcome (≥30% improvement in the mean pain intensity) and those suffering adverse events in the intervention and placebo groups were used to calculate effect sizes using the log odds ratio. The meta-analysis showed that TTX significantly increased the number of responders (mean = 0.68; 95% CI: 0.19–1.16, p = 0.0065) and the number of patients suffering non-severe adverse events (mean = 1.13; 95% CI: 0.31–1.95, p = 0.0068). However, TTX did not increase the risk of suffering serious adverse events (mean = 0.75; 95% CI: −0.43–1.93, p = 0.2154). In conclusion, TTX showed robust analgesic efficacy but also increased the risk of suffering non-severe adverse events. These results should be confirmed in further clinical trials with higher numbers of patients.
/sup 18/O states via the /sup 14/C(/sup 6/Li,d)/sup 18/O reaction at 34 MeV incident energy

The reaction $^{14}\mathrm{C}(^{6}\mathrm{Li},d)^{18}\mathrm{O}$ is studied at 34 MeV $^{6}\mathrm{Li}$ incident energy in the ${5}^{\ensuremath{\circ}}\ensuremath{\le}{\ensuremath{\theta}}_{\mathrm{lab}}\ensuremath{\le}{45}^{\ensuremath{\circ}}$ angular range in steps of 5\ifmmode^\circ\else\textdegree\fi{}. Angular distributions are analyzed in terms of Hauser-Feshbach and exact finite range distorted-wave Born-approximation theories. The direct $\ensuremath{\alpha}$-transfer cross sections are evaluated in both the hypotheses of transfer to pure and mixed configurations. In the mixed configurations case good agreement between experimental and theoretical cross sections is found by using the empirical wave functions of Lawson, Serduke, and Fortune. Alpha-spectroscopic strengths are extracted for $^{18}\mathrm{O}$ states lying below 17.0 MeV excitation energy. Spins and parities are suggested for the 7.84, 8.9, 12.04, 14.6, and 17.0 MeV $^{18}\mathrm{O}$ levels. The existence and the structure of a positive-parity $^{18}\mathrm{O}$ rotational band is investigated.
Estimation of the Equivalent Radar Reflectivity Factor from Measured Snow Size Spectra.

Abstract In this paper, a method for the estimation of radar reflectivity from measured snow particle size distributions is presented based on earlier works of Marshall and Gunn and of Smith. During two snowfalls, the method was applied to estimate the equivalent reflectivity factor from measured snow size distributions obtained by the Particle Size and Velocity (PARSIVEL) optical disdrometer. The results are compared with the data of conventional C-band Doppler radar. Here, two snowfalls are presented as case studies. In addition, a comparison during one rainfall is included, which shows good agreement between the two instruments. In the case of snow, the calculation of the equivalent reflectivity factor from the PARSIVEL data is based on a relation between the mass and the size of the snow particles. In this study, a mass–size relation for graupel-like snow was used for all snowfalls. Because this is a crude description of naturally occurring snow, which can be of any other type (e.g., dendrites), the d.
Contact fibrations over the 2-disk

Speaking of the candidate, I must say that he masters most of the techniques available in Contact Topology as the writing of Chapter 2 and 3 show. He has also a deep formation in Algebraic Geometry, Algebraic Topology and Differential Geometry. He is clearly a mature mathematician. He has an awesome enthusiasm and energy that makes enjoyable to teach him and to discuss with him for hours and hours.
PERFORMANCE OF WHEAT GENOTYPES UNDER RESTRICTED IRRIGATION CONDITIONS

A field experiment in split plot design was laid out to identify the genotypes that yield better under restricted irrigation conditions. The experiment was conducted during rabi -2006-07 with three irrigation levels viz . , I 1 - no irrigation, I 2 -one irrigation at CRI and I 3 - two irrigations at CRI and late tillering in main plot and four varieties viz. , V 1 - MP 3211, V 2 - NI 5439,V 3 - WH 147 and V 4 - HW-2004 as sub plot treatment replicated three times. The results revealed that, two irrigations at CRI and late tillering stages gave significantly higher grain yield (35.45 q/ha). The wheat variety WH-147gave maximum grain yield (25.27qt/ha.) than other varieties.
Growth, slaughter performance and selected meat quality traits of New Zealand White and Grey Flemish Giant rabbits and their crosses

The purpose of the study was to compare the growth, slaughter performance and selected meat quality traits (such as meat texture and basic chemical composition of meat) of New Zealand White (NZW) rabbits, Grey Flemish Giant (GFG) rabbits and their crossbreds. Pre-slaughter, slaughter and meat quality traits were analyzed for 52 (26 male and 26 female) New Zealand White rabbits, 42 (21 male and 21 female) Grey Flemish Giant rabbits and 78 (39 male and 39 female) crosses thereof. After weaning at 35 days of age, animals were fed pellets ad libitum. Rabbits were weighed weekly from birth to 12 weeks of age. Slaughter and dissection at 12 weeks of age were performed. Body weight measurements showed that GFG rabbits, up to and including week 4, were characterized by significantly higher body weights compared to NZW rabbits and their crossbreds. In the 5th and 6th weeks of rearing the differences between the kits were not significant. From the 7th to the 10th week of life, the highest body weight was characteristic of crossbred rabbits. In the last two weeks of life, the highest body weight was achieved by young rabbits of the GFG breed. Significantly the greatest slaughter weight was attained by GFG rabbits, while the lowest value of this parameter was obtained by purebred NZW rabbits. The highest warm carcass weight and cold carcass weight were achieved by animals from the crossbred group. The shear force value was identical in the NZW rabbits and the crossbred group, while it was lower in the GFG rabbits. Hardness and chewiness were lowest in the NZW rabbit. Springiness and cohesiveness were highest in NZW rabbits. The meat of the crossbreds had the highest protein content and the lowest fat content. It was also shown that crossbreds had the highest water content in their meat and consequently statistically the lowest dry matter content.
What Do Investors Value? A Multidisciplinary Review

This study offers a comprehensive and multidisciplinary review of the research on the antecedents of investor valuation in the management, accounting, and finance literature. Despite the growing recognition of the importance of investors and financial markets, our current understanding of the factors that drive investor valuation remains incomplete. To address this gap, we classify the existing literature on investor valuation into three perspectives: social, cognitive, and economic. The social perspective examines how social forces, such as institutional norms and pressure, shape investor valuation. The cognitive perspective focuses on the psychological underpinnings of investors’ valuation decisions, while the economic perspective emphasizes how investors determine the value of firms through rational cost-and-benefit calculations. This review compares the research on investor valuation in the management literature to that in the accounting and finance literature, identifying gaps in the management literature and discussing emerging trends that may influence investor valuation. The review also proposes an agenda for future research. In conclusion, this study illuminates the intricate and multifaceted nature of investor valuation, as well as the underlying factors that influence it.
Discussion and application of velocity profile in open channel with rectangular cross-section

Based on the theoretical analysis and experimental studies, the mean velocity distribution laws in open channel with rectangular cross section are established. It is found that the mean velocity distribution is parabolic in the vertical direction, and the distribution is of the power form in the transverse direction. The determination method of the coefficients in the distribution laws is also given in the paper. From the validation with the data in different channels, it indicates that the established velocity distribution laws have the same characteristics with the real ones; the relative errors at measuring points are small and meet the requirement of engineering. The suggested method according to the findings for continuing measurement of velocily and discharge is valuabe for simplifying the measuring work and incresing the measuring accuracy in open channels.
On the Scaling and Growth Limit of Fluvial Dunes

Bedforms emerge in a variety of shapes and sizes when a granular erodible surface is subject to a strong enough shear flow, as observed in topographic data from submarine canyons, rivers, deserts, and planetary bodies. The two salient features of bedforms are the ability to collectively transport particles, and to generate form drag thus increasing flow resistance. These two mechanisms are in competition and contribute to force bedforms of increasing size migrating more slowly. In a dedicated large‐scale open channel flow facility, hierarchies of fluvial bedforms were generated and measured in equilibrium conditions. The corresponding scale‐dependent migration velocity and mass flux contributions were quantified in the wave number and frequency domains. Experimental results are paired with a validated set of theoretical models to demonstrate that ripples or dunes reach an equilibrium state when drag partitioning ensures high enough frictional drag to sustain the bedload transport of sediment, and low enough form drag to enable the migration of the largest bedform size. This mechanism is inferred to constrain the growth of bedforms when sediment supply is not the limiting factor.
Receptor–Ligand Binding: Effect of Mechanical Factors

Gaining insight into the in situ receptor–ligand binding is pivotal for revealing the molecular mechanisms underlying the physiological and pathological processes and will contribute to drug discovery and biomedical application. An important issue involved is how the receptor–ligand binding responds to mechanical stimuli. This review aims to provide an overview of the current understanding of the effect of several representative mechanical factors, such as tension, shear stress, stretch, compression, and substrate stiffness on receptor–ligand binding, wherein the biomedical implications are focused. In addition, we highlight the importance of synergistic development of experimental and computational methods for fully understanding the in situ receptor–ligand binding, and further studies should focus on the coupling effects of these mechanical factors.
Factors Influencing Consumer Behavior

There are many prior studies that focused on the adoption of mobile shopping by apply models like TAM, DOI and UTAUT, but there is still a lack of effort to determine the influential factors from user or consumer perception. The purpose of this paper is to determine the influential factors on intention of purchasing via mobile shopping application in Malaysia. The study identified five independent variables including perceived benefit, performance expectancy, security and privacy, perceived ease of use and customer services with proposed an integrated framework to understand intention mobile users. A total of 195 mobile device users were participating in this questionnaire survey in Malaysia. Collected data was utilized to analyze the hypothesized relationships. The results indicated that only two influential factors, namely perceived benefits and perceived ease of use were significant in predicting the purchase intention via mobile shopping application. The small sizes of respondents from whole population in Malaysia is the limitation of this study. The findings of this study benefit mobile shopping app developers to develop a suitable services and strategies to encourage mobile shopping app as a medium of exchange. Worth noting this study represents the purchase intention in using mobile application by using UTAUT model as a guiding theory.
Description and life cycle of a new species of the genus Arachnanthus (Cnidaria: Anthozoa: Ceriantharia) from the Southwestern Atlantic Ocean

Background Ceriantharia is a subclass of the phylum Cnidaria, which comprises tube-dwelling marine invertebrates. This subclass is composed of three families, including Arachnactidae, with two known genera. Currently, the genus Arachnanthus has five valid species recorded from Australia, the Mediterranean Sea and both the Southern and Northern Pacific Ocean. However, at the moment, there is no record of organisms of this family from the South Atlantic Ocean. Besides that, the life cycle of any species of the genus Arachnanthus is known. The present study describes a new species of the genus Arachnanthus and its life cycle, based on specimens from Uruguay and South of Brazil. Methods Larvae were collected by plankton net in Rio Grande—Brazil and the development and external morphology of these specimens were observed in the laboratory during two years, and subsequently described. Additionally, nine adult ceriantharians correspondent to the larvae from Rio Grande were collected in Uruguay and their external and internal anatomies, and cnidome were described. Results Arachnanthus errans sp. nov. exhibited a free-swimming, short-lived cerinula larvae that spent short-time on the plankton. The larva developed into small and translucent polyps with a short actinopharynx, one pair of mesenteries attached to a siphonoglyph, and a medium first pair of metamesenteries. Further, the adult polyp displayed an unprecedented locomotion behavior in Ceriantharia that is first reported here, it can crawl under and in between the sediment.
EFFECT OF LASER POWER AND POWDER MORPHOLOGY ON SURFACE ROUGHNESS OF TI6Al4V PRODUCED BY LASER POWDER - DIRECTED ENERGY DEPOSITION

: Additive manufacturing of metals has emerged as a technology capable of producing complex metal parts in the “near net shape” format, performing repairs, and creating parts with gradient material, enabling manufacturing parts with high added value and low production. Directed Energy Deposition from Laser and Powder (LP-DED) is one of the categories of the additive manufacturing process by which concentrated thermal energy allows the metallic powder to melt. These applications have been attractive to different areas such as aerospace, automotive, and medical. In the medical field, its application has focused on creating implants, prostheses, instruments, and medical devices. In the creation of prostheses and implants, Ti6Al4V titanium alloys have stood out due to their properties of high mechanical strength, high corrosion resistance, low density, and, essentially, good biocompatibility. One of the literature challenges reflects the roughness given to printed parts by the LP-DED process, which can affect the osseointegration of prostheses and implants, linked to their recovery time and success. This article evaluates the roughness of Ti6Al4V parts obtained from the LP-DED process using two types of powder. The first is produced by gas atomization, and the second is produced by advanced plasma atomization. Subsequently, eight specimens were fabricated by LP-DED on pure Ti substrate. The laser power was another input variable ranging from 300 W to 345 with a 15W increment. Samples were cleaned with deionized water and acetone using ultrasonic vibration. Then, we evaluated the roughness of the samples using a confocal microscope. The Powder morphology of the powder used showed that powder produced by gas atomization presented a distribution non-gaussian, with flakes, pores, and satellites. The powder produced by advanced plasma atomization showed a gaussian distribution, with fewer pores quantity and less presence of satellites and flakes when compared with gas atomization powder.
Mesoscale factors contributing to the extreme rainstorm on 20 July 2021 in Zhengzhou, China as revealed by rapid update 4DVar analysis

The purpose of this study is to diagnose mesoscale factors responsible for the formation and development of an extreme rainstorm that occurred on 20 July 2021 in Zhengzhou, China. The rainstorm produced 201.9 mm rainfall in one hour, breaking the record of mainland China for 1-h rainfall accumulation in the past 73 years. Using 2-km continuously cycled analyses with 6-min updates that were produced by assimilating observations from radar and dense surface networks with a four-dimensional variational (4DVar) data assimilation system, we illustrate that the modification of environmental easterlies by three mesoscale disturbances played a critical role in the development of the rainstorm. Among the three systems, a meso-beta-scale low pressure system (mesolow) that developed from an inverted trough southwest of Zhengzhou was key to the formation and intensification of the rainstorm. We show that the rainstorm formed via sequential merging of three convective cells, which initiated along the convergence bands in the mesolow. Further, we present evidence to suggest that the mesolow and two terrain-influenced flows near the Taihang mountains north of Zhengzhou, including a barrier jet and a downslope flow, contributed to the local intensification of the rainstorm and the intense 1-h rainfall. The three mesoscale features co-existed near Zhengzhou in the several hours before the extreme one-hour rainfall and enhanced local wind convergence and moisture transport synergistically. Our analysis also indicated that the strong midlevel south/southwesterly winds from the mesolow along with the gravity-current-modified low-level northeasterly barrier jet enhanced the vertical wind shear, which provided favorable local environment supporting the severe rainstorm.
A Single-Stage AC–DC Converter Based on Semi Dual-Active-Bridge With Decoupled Inductor Current Modulation Strategy

In this article, a novel decoupled inductor current modulation strategy for a single-stage ac–dc converter based on a semi dual-active-bridge is proposed, which helps minimize the total harmonic distortion (THD) and improve the conversion efficiency. The transformer turns ratio is designed in an optimized manner for higher conversion efficiency. Only two control variables are used. And the converter could achieve a wider output voltage range and a high power factor without the mandatory current-tracking loop and look-up tables. In addition, comparisons of losses, THD, and backflow power between the decoupled inductor current and the optimal peak current modulation are presented. The power transfer capability, mode transition mechanism, soft-switching range, mode operation region, and parameter design are analyzed. The switches can achieve zero-voltage-switching within a wide operating range, and rectifier diodes can achieve zero-current-switching off in all operation situations. Besides, a 1-kW experimental prototype was built to verify the effectiveness of the proposed control strategy.