Miracle-dz/UniFAR-FTUs huggingface dataset:
Positive effect of Balint group on burnout and self-efficacy of head nurses in China: a randomized controlled trial

Background Burnout is common among nurses and can lead to negative outcomes of medical care. This study aimed to explore the effectiveness of Balint groups to reduce burnout in head nurses in a Chinese hospital. Methods This was a randomized controlled trial with a pre- and post-test. A total of 80 head nurses were randomly assigned to either a Balint group (n = 40) or a control group (n = 40). Participants participated in Balint group for a period of 3 months. Participants in both groups completed the Maslach Burnout Inventory-Human Services Survey and the General Self-Efficacy Scale at the beginning and end of the study. Balint group members also completed the Group Climate Questionnaire-Short Form. Results In the Balint group, 33 participants attended all Balint groups, while the 40 participants in the control group had no intervention. Analysis of variance with repeated measures demonstrated a statistically significant difference on the Maslach Burnout Inventory subscale of sense of personal achievement (F = 9.598, p = 0.003) between the Balint and control groups. However, there were no significant differences between the groups on the subscales of emotional exhaustion (F = 0.110, p = 0.740) and depersonalization (F = 0.75, p = 0.387), and the General Self-Efficacy Scale (F = 0.709, p = 0.403). Conclusions Balint groups helped reduce burnout among head nurses in terms of personal achievement.
The Correlation between Serum Uric Acid and Renal Function in Elderly Chinese Diabetes with Normoalbuminuria

Objective The elder diabetic patients increases rapidly in China and often accompany with hyperuricemia. Recently evidences show that renal function has been impaired in part of diabetic patients with normoalbuminuria. Therefore, we investigated the relationship between serum uric acid (SUA) and renal function in Chinese elder diabetes with normoalbuminuria. Methods The physical examination data from 1052 cases of diabetic residents with normoalbuminuria aged 70 years and over in the Jiangchuan community of Minhang District, Shanghai, from October 2011 to September 2014 was analyzed retrospectively. Each received height, body weight, waist circumference (WC), waist-to-hip ratio (WHR), blood pressure (BP), and collected samples of fasting blood and morning urine to detect blood routine, blood glucose, glycosylated hemoglobin (HbA1c), blood lipids, serum creatinine, urinary albumin, urine creatinine, and urine PH value. Correlation between SUA and renal function, an index of which is estimated using estimated glomerular filtration rate (eGFR), was analyzed. Results The prevalence of hyperuricemia was 21.10%. Levels of WC and triglyceride (TG) increased and the levels of HbA1c, high density lipoprotein-cholesterol (HDL-C), eGFR, and urine PH decreased while the levels of SUA increased. Moreover, negative correlation of eGFR with age, WC, leukocyte, and SUA (Pearson r=0.415) was observed via Pearson correlation analysis. It indicates the strong association between SUA and eGFR. Furthermore, eGFR independently associated with SUA, age, leukocyte, hemoglobin (Hb), and fasting blood glucose (FBG) was confirmed by multiple linear stepwise regression analysis. Conclusion SUA may play an important role in the decrease of eGFR in elderly Chinese diabetic patients with normoalbuminuria.
Ferric citrate’s efficacy for hyperphosphatemia and anemia in NDD-CKD: a meta-analysis

This meta-analysis aims to evaluate the impact of ferric citrate (FC) treatment on hyperphosphatemia and iron-deficiency anemia (IDA) in non-dialysis-dependent chronic kidney disease (NDD-CKD) patients. A comprehensive search was conducted across multiple databases, namely PubMed, Embase, Cochrane, EBSCO, Scopus, Web of Science, Wanfang Data, CNKI, and VIP databases. The purpose of this search was to identify randomized controlled trials (RCTs) pertaining to the management of hyperphosphatemia and anemia in NDD-CKD patients. The search encompassed the entire duration of the databases, up until June 2023. RevMan 5.4. 0 and Stata 16.0 were used for data analysis. A total of 8 studies involving 1281 NDD-CKD patients were included in this meta-analysis. In comparison to the control group, FC treatment led to a notable decrease in serum phosphorus levels. Additionally, FC treatment improved iron, hemoglobin, ferritin, and transferrin saturation (TSAT) levels. Findings of this meta-analysis suggest that FC has positive effects in managing hyperphosphatemia and IDA in NDD-CKD patients.
Evaluating the Effects of Culvert Designs on Ecosystem Processes in Northern Wisconsin Streams

Culvert replacements are commonly undertaken to restore aquatic organism passage and stream hydrologic and geomorphic conditions, but their effects on ecosystem processes are rarely quantified. The objective of this study was to investigate the effects of two culvert replacement designs on stream ecosystem processes. The stream simulation design, where culverts accommodate bankfull width and streambeds are reconstructed through the culvert, was compared with the bankfull and backwater design, where streambeds were left to fill naturally, as well as to non‐replaced culverts. We predicted that stream simulation culverts would best preserve water velocity and coarse particulate organic matter (CPOM) retention within the culvert relative to upstream reaches, and that both replaced culvert styles would exhibit rates closer to upstream reaches than non‐replaced culverts. In addition, we predicted that ecosystem processes (CPOM retention, transient storage and nutrient uptake) would be similar in reaches upstream and downstream of both replaced culvert styles, because both designs are constructed to maintain stream slopes and bankfull widths through the structure. We found that stream simulation design better maintained CPOM retention through culverts compared with non‐replaced and bankfull and backwater design culverts, but observed no differences in ecosystem processes between reaches located upstream or downstream of replaced culverts. Although the stream simulation design requires additional streambed construction relative to the bankfull and backwater design, this step may lead to additional improvement if maintaining ecological conditions through the culvert is an important restoration goal. Copyright © 2017 John Wiley & Sons, Ltd.
KINEMATIC CONSTRAINTS ON TECTONICS OF THE NORTHERN BASIN AND RANGE

We derive surface velocities relative to North America, using data from 1989 through 2014 in the interior northwest, to investigate kinematics from the Snake River Plain (SRP) to the Canadian border. The Centennial Tectonic Belt (CTB) exhibits similarities to the main Basin and Range Province (BRP) that suggest the CTB is an extension of the BRP, including range and fault orientation, increasing velocity magnitudes westward, and a distinct high rate of strain across the Madison Range. Calculations of fault spreading rates and orientations from geodetic data show that several faults are more active than previously assumed when compared to seismic and paleoseismic rates, while structural and geomorphic rates do not exhibit consistent correlation. The northern section of the Madison Fault was previously estimated to be spreading less than 0.2 mm y, however we derived a rate of 1.2 mm y from geodetic data constraining nearly half of the CTB spreading rate of 2.6 mm y to the Madison Fault. Comparing the mean velocity of the CTB to that of the SRP we find a dextral slip of 0.9 mm y.
WeChat News Contact among Chinese Youth and Impact on Political Participation: the Role of Social Capital, Political Trust, and Media Literacy

Several recent studies have found that social media positively influences the online political participation behavior of youth. However, only a few studies have explored the political participation behavior of Chinese youth on specific social media, such as WeChat, the most widely used mobile social media in China. To bridge this gap, this study examines Chinese youths’ contact with WeChat and its subsequent impact on political participation. The study uses a questionnaire to collect data and uses the SPSS 25.0 version to analyse data. The findings show that: (1) Chinese youths' WeChat news contact positively affects their WeChat political participation; (2) Chinese youths' social capital positively affects their political trust; (3) social capital and political trust play a partially mediating role between youths' WeChat news contact and youths' WeChat political participation; (4) media literacy plays a moderating role between youth WeChat news contact and youth WeChat political participation. Implications and limitations of the ﬁndings are discussed.
Disaggregating Orders of Water Scarcity - The Politics of Nexus in the Wami-Ruvu River Basin, Tanzania

This article considers the dilemma of managing competing uses of surface water in ways that respond to social, ecological and economic needs. Current approaches to managing competing water use, such as Integrated Water Resources Management (IWRM) and the concept of the water-energy-food nexus do not adequately disaggregate the political nature of water allocations. This is analysed using Mehta’s (2014) framework on orders of scarcity to disaggregate narratives of water scarcity in two ethnographic case studies in the Wami-Ruvu River Basin in Tanzania: one of a mountain river that provides water to urban Morogoro, and another of a large donor-supported irrigation scheme on the Wami River. These case studies allow us to explore different interfaces in the food-water-energy nexus. The article makes two points: that disaggregating water scarcity is essential for analysing the nexus; and that current institutional frameworks (such as IWRM) mask the political nature of the nexus, and therefore do not provide an adequate platform for adjudicating the interfaces of competing water use.
The Predictors of Incidental Durotomy in Patients Undergoing Pedicle Subtraction Osteotomy for the Correction of Adult Spinal Deformity

Background: Pedicle subtraction osteotomy (PSO) is a powerful tool for sagittal plane correction in patients with rigid adult spinal deformity (ASD); however, it is associated with high intraoperative blood loss and the increased risk of durotomy. The objective of the present study was to identify intraoperative techniques and baseline patient factors capable of predicting intraoperative durotomy. Methods: A tri-institutional database was retrospectively queried for all patients who underwent PSO for ASD. Data on baseline comorbidities, surgical history, surgeon characteristics and intraoperative maneuvers were gathered. PSO aggressiveness was defined as conventional (Schwab 3 PSO) or an extended PSO (Schwab type 4). The primary outcome of the study was the occurrence of durotomy intraoperatively. Univariable analyses were performed with Mann–Whitney U tests, Chi-squared analyses, and Fisher’s exact tests. Statistical significance was defined by p < 0.05. Results: One hundred and sixteen patients were identified (mean age 61.9 ± 12.6 yr; 44.8% male), of whom 51 (44.0%) experienced intraoperative durotomy. There were no significant differences in baseline comorbidities between those who did and did not experience durotomy, with the exception that baseline weight and body mass index were higher in patients who did not suffer durotomy. Prior surgery (OR 2.73; 95% CI [1.13, 6.58]; p = 0.03) and, more specifically, prior decompression at the PSO level (OR 4.23; 95% CI [1.92, 9.34]; p < 0.001) was predictive of durotomy. A comparison of surgeon training showed no statistically significant difference in durotomy rate between fellowship and non-fellowship trained surgeons, or between orthopedic surgeons and neurosurgeons. The PSO level, PSO aggressiveness, the presence of stenosis at the PSO level, nor the surgical instrument used predicted the odds of durotomy occurrence. Those experiencing durotomy had similar hospitalization durations, rates of reoperation and rates of nonroutine discharge. Conclusions: In this large multisite series, a history of prior decompression at the PSO level was associated with a four-fold increase in intraoperative durotomy risk. Notably the use of extended (versus) standard PSO, surgical technique, nor baseline patient characteristics predicted durotomy. Durotomies occurred in 44% of patients and may prolong operative times. Additional prospective investigations are merited.
Impact of gut microbiota on nonalcoholic fatty liver disease: insights from a leave-one-out cross-validation study

Introduction Enteric dysbacteriosis is strongly associated with nonalcoholic fatty liver disease (NAFLD). However, the underlying causal relationship remains unknown. Thus, the present study aimed to investigate the relationship between gut microbiota and NAFLD using Mendelian randomization (MR) and analyze the target genes potentially regulated by specific microbiota. Methods Bidirectional two-sample MR analysis was performed using inverse variance weighted (IVW) supplemented by MR-Egger, weighted median, simple mode, and weighted mode methods. Data were pooled from gut microbiota and NAFLD association studies. The least absolute shrinkage, selection operator regression, and the Support Vector Machine algorithm were used to identify genes regulated by these intestinal flora in NAFLD. The liver expression of these genes was verified in methionine choline-deficient (MCD) diet-fed mice. Results IVW results confirmed a causal relationship between eight specific gut microbes and NAFLD. Notably, the order Actinomycetales, NB1n, the family Actinomycetaceae, Oxalobacteraceae and the genus Ruminococcaceae UCG005 were positively correlated, whereas Lactobacillaceae, the Christensenellaceae R7 group, and Intestinibacter were negatively correlated with NAFLD onset. In NAFLD, these eight bacteria regulated four genes: colony-stimulating factor 2 receptor β, fucosyltransferase 2, 17-beta-hydroxysteroid dehydrogenase 14, and microtubule affinity regulatory kinase 3 (MAPK3). All genes, except MARK3, were differentially expressed in the liver tissues of MCD diet-fed mice. Discussion The abundance of eight gut microbiota species and NAFLD progression displayed a causal relationship based on the expression of the four target genes. Our findings contributed to the advancement of intestinal microecology-based diagnostic technologies and targeted therapies for NAFLD.
Breast cancer related lymphedema—novel regenerative therapies: a narrative review

Background and Objective: In the last decade, surgical treatment options for breast cancer-related lymphedema (BCRL), such as microvascular autologous lymph node transfer (ALNT) and/or lymphatic venous anastomosis (LVA) have become popular. The results have been promising, but the benefit has been seen mostly on patients suffering from early stages of lymphedema. BCRL can deteriorate patient well-being in a significant manner. Our objective is to review the current field of novel regenerative therapies in association with surgical reconstruction of the lymphatic vasculature and further provide ideas for possible future improvements in the treatment of lymphedema. Methods: We searched the PubMed Medline database for regenerative therapies for BRCL during the years 2000–2022. Articles written in English were included. Key Content and Findings: Results from ALNT and/or LVA seem to improve with growth factor therapy and nanofibrillar collagen scaffold insertion, also adipose-derived stem cells (ADSCs) have improved results in some studies. These methods do not target the fibrofatty tissue in lymphedema, and liposuction (LIPO) can be added to the treatment. Conclusions: Regenerative therapies have shown promising results in the treatment of lymphedema in experimental models. The research has proceeded to clinical studies in several treatment options but to date no curative treatment has been found. The translation of result of experimental studies to the clinical practice has not been straightforward. The pathogenesis of BCRL is multifactorial and patients are very heterogenous, which creates challenges to the researchers in this field.
Preliminary Study: Analysis of the Need for Physics E-Modules as Guided Inquiry-Based Teaching Materials at MAN 1 Mandailing Natal

This research was carried out to develop a learning resource type of learning media in the form of guided inquiry-based teaching materials. So, preliminary study research is needed which consists of literature study and field study. The type of research carried out was qualitative descriptive research. The data collection instruments for this research are interview sheets, teacher needs analysis questionnaires, and student needs analysis questionnaires. The teaching materials developed are in the form of (e-modules) electronic modules that can contain text, images and learning videos, as an independent learning effort that is arranged systematically. To create an e-module using the Canva application. A needs analysis is carried out to determine the learning resources used by teachers, obstacles when learning takes place, and the learning resources needed by students. The results of the analysis of teacher needs show that religious analysis is 83% in the good category, attitude analysis is 94% in the very good category, knowledge analysis is 65% in the sufficient category, performance analysis is 83% in the good category, analysis of learning difficulties is 58% in the poor category, material analysis teaching 50% in the poor category and model analysis 67% in the sufficient category. Furthermore, the results of the analysis of students' needs show that motivation analysis is 70% in the sufficient category, interest analysis is 50% in the poor category, attitude analysis is 81% in the good category, creative thinking analysis is 49% in the poor category and material analysis is 48% in the poor category. These results indicate the need to develop teaching materials in the form of e-modules based on guided inquiry on global warming.
New insights into a poorly known parasite, Dero lutzi (Oligochaeta: Naididae), associated with tree frogs of the genus Scinax: morphological evaluation and genotypic data

Abstract The oligochaete Dero lutzi follows a life strategy that alternates between free-living periods in aquatic environments and endoparasitic phases. Most occurrences of D. lutzi in anurans are reported in species with arboreal habits, with studies limited to the recording of the oligochaete’s presence in the host. Our study recovered specimens of D. lutzi from the tree frogs Scinax fuscovarius and Scinax. nasicus. We performed a morphological assessment of the parasite using light microscopy, for the first time, scanning electron microscopy. Molecular characterization of D. lutzi was carried out using the mitochondrial gene 16S rRNA and the nuclear gene 28S rRNA. Additionally, a phylogenetic tree was constructed to assess the species´position in relation to other group members. In our results, we confirmed the phenotypic morphological characteristics of the endoparasitic phase of D. lutzi. We also presented its phylogenetic position with other oligochaetes in the group, demonstrating the proximity between the endoparasite D. lutzi and the free-living oligochaete D. superterrenus.
Would You Mind Sharing Your Opinion About the Covid-19 Vaccination?

The present study investigates predictors of opinion expression about the Covid-19 vaccination. Health-related opinion expressions, which can be understood as a specific type of information sharing, are highly relevant since opinions are influential sources for individuals’ health-related attitude formation and decision-making and shape public opinion about health topics. Guided by extensive research on political opinion expression and the current state of research addressing health information sharing, we apply theoretical assumptions of the risk information seeking and processing model (RISP) to opinion expression about vaccination in different social contexts. We conducted an online survey in Germany (N = 833) and empirically analysed our model using regression analyses. A higher likelihood to express one’s opinion was contextual-independently facilitated by more positive attitudes towards sharing, injunctive norms, and sharing efficacy. Context-specific patterns were found for descriptive norms, cognitive risk perceptions, and information seeking. Our results revealed the RISP to be a step towards a theoretically sound framework explaining opinion expression, but demand more specific frameworks developed for opinion expression.
Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours

Tumours defective in the DNA homologous recombination repair pathway can be effectively treated with poly (ADP-ribose) polymerase (PARP) inhibitors; these have proven effective in clinical trials in patients with BRCA gene function-defective cancers. However, resistance observed in both pre-clinical and clinical studies is likely to impact on this treatment strategy. Over-expression of phosphoglycoprotein (P-gp) has been previously suggested as a mechanism of resistance to the PARP inhibitor olaparib in mouse models of Brca1/2-mutant breast cancer. Here, we report that in a Brca2 model treated with olaparib, P-gp upregulation is observed but is not sufficient to confer resistance. Furthermore, resistant/relapsed tumours do not show substantial changes in PK/PD of olaparib, do not downregulate PARP1 or re-establish double stranded DNA break repair by homologous recombination, all previously suggested as mechanisms of resistance. However, resistance is strongly associated with epithelial-mesenchymal transition (EMT) and treatment-naïve tumours given a single dose of olaparib upregulate EMT markers within one hour. Therefore, in this model, olaparib resistance is likely a product of an as-yet unidentified mechanism associated with rapid transition to the mesenchymal phenotype.
The effect of agricultural chemicals on the biological activity of Southern Chernozem

The effect of the combined application of different systems of fertilization (traditional, minimal, and organic) and crop protection (intensive, integral, and biological) on the biological activity of southern chernozem was studied in this field experiment. The most informative parameters of biological activity were determined and shown to be the indices describing yields and soil fertility.
Past trends, present stocks and possible future state of the fisheries of the Tanzania part of the Lake Victoria

The Tanzania part of Lake Victoria is the most important single fishery resource for the country. Past fishing practice caused disparity between the relative abundance in the catches and in the available stocks by overfishing some species while under-fishing others. Preliminary studies of distribution pattern, biomass estimates, etc, as derived from bollom trawl exploratory data, and the trend of the commercial catch statistics from 1958 to 1970, suggest that many of the commercially preferred species may not have the biotic potential 10 sustain higher yields under present ecological and fishing regimes. Haplochromis and a few other fish might be the only hope. Geographic extension of fishing to deeper waters may not be very promising as species diversificarion and fish density decline with depth. To develop and manage the fisheries, make full use of the resource and ensure economic and biological perpetuation of thc fishery, the appropriate fishing strategy cannot be properly developcd overnight.