Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimisation of GnRH antagonist use in ART

This thesis focuses on the optimisation of controlled ovarian stimulation for IVF using exogenous FSH and GnRH antagonist co-treatment, by studying the timing of the initiation of GnRH antagonist co-medication and the role of ovarian reserve markers in optimising ovarian response and reproductive outcome. In this thesis we describe the results of a multicentre randomised controlled trial (RCT) which studied the effect of early (cycle day (CD) 2) versus late (CD 6) GnRH antagonist initiation on the stimulation phase endocrine profile as well as the impact on live birth rate per started cycle (LBR) and the cumulative live birth rate (CLBR). Early initiation of GnRH antagonist treatment resulted in a more stable endocrine profile, with more physiological levels of estradiol and LH during the follicular phase. However, live birth rates did not differ significantly between the two groups, although a non-significant trend towards a higher LBR and CLBR was observed in the late start group compared with the early start group. Thus, despite a more stable endocrine profile early initiation of GnRH antagonist does not appear to improve clinical outcomes of IVF compared with standard midfollicular initiation. Therefore the current late start GnRH antagonist protocol remains the best protocol at present and further adjustments in the timing of GnRH antagonist co-treatment are deemed useless. We further assessed the impact of elevated early follicular progesterone levels in GnRH antagonist co-treated cycles on ongoing pregnancy rate by using prospective data from the RCT in combination with a systematic review and meta-analysis. It was demonstrated that elevated early follicular progesterone levels have a negative impact on the chance of achieving a pregnancy. In view of the low incidence of elevated early follicular progesterone levels and the absence of an effective strategy, routine screening is, however, not recommended. It may be more useful to focus on the individualisation of GnRH antagonist co-treated cycles by using ovarian reserve tests such as AMH. This thesis further describes the clinical value of AMH and other patient characteristics for the prediction of high or low ovarian response in controlled ovarian stimulation using GnRH antagonist co-treatment. It was demonstrated that AMH had a better accuracy for the prediction of both high and low response as compared to age and BMI. Furthermore, AMH had a better accuracy for the prediction of high response than for low response and showed similar accuracy as reported in previous studies on GnRH agonists. Finally, it was demonstrated that although AMH was associated with pregnancy, its predictive accuracy was very modest even when assessing the cumulative pregnancy rate.Thus, AMH alone or in combination with age, is unlikely to alter clinical decisions based on the chance of an ongoing pregnancy or live birth after IVF treatment and should therefore preferably only be used for ovarian response prediction.
Foot Massage Modification to Reduce Blood Pressure in Pregnant Woman with Preeclampsia

The Maternal Mortality Ratio (MMR) in Indonesia remains high, including in West Java province. One of the MMR causes is preeclampsia (24%). Currently, the management of preeclampsia is focused on pharmacological therapy. Preeclampsia is characterized by high blood pressure. S ome studies revealed that non-pharmacological therapy was effective in dealing high blood pressure including foot massage. Foot message has benefits both physiologically and psychologically. However limited study applied this massage among pregnant women with preeclamsia. The aim of this study was to determine the effectiveness of as a complementary therapy: foot massage to reduce of blood pressure among pregnant women with preeclampsia. The study applied quasi experimental design with time series approach. The samples were chosen using consecutive sampling technique. This study involved 30 pregnant women with preeclampsia. There were two steps of data collection. First, respondents’ blood pressure was measured by researchers without any interventions for 6 days. Second, the 7 th -12 th respondents had 20 minutes message, and observed blood pressure at the first minute before massage (pr-etest), and the 30 th minutes after massage (post-test). Data were analyzed using Friedman Test. The result showed that there were no significant differences of mean systolic and diastolic blood pressure between pre-test and post-test (p> 0.05) in control period. Whereas, in the treatment period showed that there were a significant differences of mean systolic blood pressure between pre-test and post-test on the seventh day until twelfth day (p < 0.05). While, the significantly differences in mean of diastolic blood pressure between pre-test and post-test were present during the eighth until twelfth in treatment period (p < 0.05). This study revealed that there were significant differences in decreasing of blood pressure among pregnant women with preeclampsia after treatment by foot massage. The foot massage techniques can be used as one of the interventions to lower blood pressure in pregnant women with preeclampsia, however further research is needed to support the evidence based for nursing intervention especially in complementary therapies.
Dietary inflammatory index in relation to obesity and body mass index: a meta-analysis

Purpose Studies investigating the association between dietary inflammatory index (DII) and body mass index (BMI) have led to inconsistent findings. Therefore, to decisively conclude, this paper aims to clarify the relationship between DII and obesity by performing meta-analysis. Design/methodology/approach PubMed, Scopus and Google Scholar were searched up to July 2017 using key words selected from Medical Subject Headings and other related keywords to identify all relevant articles. In total, 22 articles were entered into the meta-analysis; 22 studies compared the mean of BMI among subjects with highest versus the lowest DII and 4 studies had data on the hazard risk (HR) or odds ratio (OR) for obesity. Findings A meta-analysis on included studies indicated a significant association on either mean differences (MD) in BMI (MD = 0.811; 95 per cent CI: 0.365-1.256; p: 0.0001) or obesity OR (OR: 1.310; 95 per cent CI: 1.144-1.500; p = 0.000) by comparing the highest and lowest DII categories. Between-study heterogeneity was high (Cochrane Q test, p < 0.001, I2 = 98.1 per cent, df = 21, τ2 = 0.9273), and only dietary assessment methods could explain the source of heterogeneity in which 24-h dietary recalls were homogeny (I2 = 8.4 per cent, df = 2, p = 0.335). Originality/value The results of the present meta-analysis suggest that adherence to high DII score increased BMI and obesity. More prospective studies in different populations are needed to better clarify this relation.
Antioxidant Capacity of Momordica charantia Extract and its Protective Effect on Testicular Damage in Valproic Acid-Induced Rats

Although Momordica charantia (MC) has preventive effects on tissue injuries, antioxidant capacity and protective effect of MC pulp and peel (MCP) on valproic acid (VPA)-testicular damage have never been reported. Fresh MCPs were aqueous extracted and determined for antioxidant capacity and momordicine I level by HPLC. Male rats were divided into 5 groups (contro l, VPA (500 mg/kgBW), MCP20/40/ or 80 mg/kgBW+VPA). In 30 experimental days, animals were pretreated with different doses of MCPs for 20 days before VPA injection for 10 consecutive days. Sperm concentration, testosterone hormone, and testicular histology of al l gr ups were investigated. Expressions of testicular tyrosine phosphorylated and steroidogenic acute regulatory (StAR) proteins were ex amined by Western blot. Results showed that MCP contains TPC (39.24 ±0.65 ug/mg garlic acid), antioxidant capacities (FRAP=33.08 ±0.21 ug/ mg ascorbic acid equivalent, IC50 of DPPH=389.8 ±3 20 ug/ml), and momordicine I (404.9 mg/g MCP). Sperm concentration in MCP80+VPA group was increased as compared to VPA group. Testosterone level in MCP treated groups was significantly increased. MCP protected testicular damage and could prevent the decrease of StAR and a 50-kDa phosphorylated protein expression in VPAtreated testis. In conclusion, MCP has antioxidant activities and can prevent male reproductive toxicity in VPA-induced rats.
Perancangan Game Puzzle sebagai Media Pembelajaran Aksara Sunda untuk Remaja

Sunda ethnic group have their own writing system, but because of various events in Indonesia, Sunda script is no longer used. After three centuries, West Java government and Sundanese scholars try to re-introduce the script. But teenagers, as one of potential target for Sundanese script socialization, have limited time learning this script in school, while there is also limited learning media for this script outside the school. To give teenagers a better interaction with Sundanese script, such as seeing, memorizing and writing, there is a need of instructional media for Sundanese script, outside the school. One of the media that can be used for learning purposes is game. Apart from the long history, game also known for the entertainment aspect and have a good impact for learning environment such as learning strategy findings, problem solving capability and intelectual, visual and motoric capability. With the possibilities to combine Sundanese script learning and game, this research designed to create entertaining learning media for students and broader audience, in attractive and fun alphabet learning process, outside the school environment. The Sundanese script game is designed using action research, compiling data from literature review about learning system, educational game, and Sundanese script. Data also contain expert interview about Sundanese script topic. After the required data is processed, learning system that is going to be used is rote learning, while the design frameworks used is intrinsic motivation for instructional environment. Research output is composed with rote learning sytem and puzzle genre, with the consideration of many implementation of language learning using this genre. There is wide range possibilty to using different learning method and different gameplay for the same purpose. This research able to be adapted for other Indonesia traditional writing system such as Batak, Java and other syllabic writing system.
WinXSPRO, a channel cross section analyzer, User's Manual, Version 3.0

WinXSPRO is an interactive WindowsTM software package designed to analyze stream channel cross section data for geometric, hydraulic, and sediment transport parameters. WinXSPRO was specifically developed for use in high-gradient streams (gradient > 0.01) and supports four alternative resistance equations for computing boundary roughness and resistance to flow. Cross section input data may be from standard cross section surveys using a rod and level or sag-tape procedures. WinXSPRO allows the user to subdivide the channel cross section into multiple sub-sections and has the ability to vary watersurface slopes with discharge to reflect natural conditions. Analysis options include developing stagedischarge relationships, evaluating changes in channel cross-sectional area, and computing sediment transport rates. Resource specialists can use the estimated stream-channel geometry cross section hydraulic characteristics and sediment transport output to assist with channel design and monitoring, instream flow analysis, the restoration of riparian areas, and the placement of instream structures.
Identification of Small Molecule Compounds that Regulate Pdgfra Transcription in Oligodendrocyte Progenitor Cells

Oligodendrocyte progenitor cells (OPCs) are precursor cells that give rise to oligodendrocytes. Oligodendrocytes are the cells that form myelin, an arrangement of membrane sheaths enwrapping axons necessary for the fast transmission of electrical impulses in the central nervous system (CNS). OPCs generate oligodendrocytes both during development and adulthood and also after the myelin damage caused by injury or demyelinating disease. Generation of oligodendrocytes from OPCs is in part regulated by growth factors. The major survival factor and mitogen for OPCs is platelet derived growth factor (PDGF). PDGF and its receptor, PDGF receptor A (PDGFRA), are critical regulators of OPC proliferation and their differentiation into myelinating oligodendrocytes. PDGFRA gain-offunction can lead to excessive proliferation and is associated with a number of cancers, including glioma in the CNS. In terms of the role of PDGFRA in OPC differentiation, there is evidence that suggests that signaling through PDGFRA needs to be inhibited in order for OPC differentiation to occur.
ST elevated myocardial infarction: clinical manifestation and outcomes of thrombolysis in a tertiary care hospital

Background: Acute myocardial infarction has reached enormous proportion in the developing countries and it is speculated that atherosclerotic heart disease will replace infectious disease as the leading cause of death in India. It has been shown that the thrombolytic therapy is underutilized. So, the study was taken to study the clinical manifestations and outcome of thrombolytic therapy in STEMI. Methods: The study was conducted for a period of 18 months in a tertiary care centre during which 100 cases of STEMI admitted to ICCU were included in the study, after fulfilling the inclusion criteria for thrombolysis, data related to clinical profile and outcome of thrombolysis was collected. SPSS 16 was used to analyse the data. Descriptive statistics like proportions mean and SD were computed. Results: Incidence of STEMI was high among subjects in the age group 51-60 years. Males were more affected (72%). Smoking, hypertension, hyperlipidemia and diabetes mellitus were the most common risk factors. Chest pain (92%) was the most common symptom. Majority (56%) were admitted within 6 hours of onset of symptoms. Anterior wall infarction was most common type of myocardial infarction. Majority (82%) were admitted in either Killips I/II class. Left Ventricular failure and Arrhythmias were most common complication. 64% patients had objective evidence in a form of ECG with ST-T resolution (>50%) between 1-6 hours, 18% between 6-24 hours and 18% patients had no significant resolution even after 24 hours. Echocardiography showed good left ventricle function (LVEF >45%) in 70% and 30% of the patients showed reduced ejection fraction (LVEF<45%). Mortality was seen in 8% of cases. Conclusions: Smoking, hyperlipidemia, diabetes mellitus and hypertension were most important risk factors for MI in the study. Coronary pain relief was most frequent and early marker of reperfusion. The ST segment elevation resolution has been widely accepted as most reliable objective criteria of coronary reperfusion. Hence ST segment resolution is regarded as a marker of salvaged myocardium by post-thrombolytic reperfusion. Early reperfusion of the ischaemic myocardial tissue with thrombolytic therapy decreases the morbidity and mortality.
Association of Human Papillomavirus Genotype 16 Viral Variant and Viral Load with Cervical High-grade Intraepithelial Lesions

Human papillomavirus genotype 16 (HPV16) is by far the genotype most strongly associated with cervical cancer; viral variant and/or viral load of HPV16 could modulate this association. The objective was to determine the association between the viral variant and viral load of HPV16 and the presence of cervical high-grade lesions. This cross-sectional study included all women in whom HPV infection was found by cervical smear during routine gynecologic health checks. Women with single or multiple HPV16 infections (n = 176) were selected for viral variant and viral load analysis. Smear results were classified using the Bethesda system. HPV types were classified according to the International Agency for Research on Cancer. Odds ratios (OR) with their 95% confidence intervals (CI) were estimated by logistic regression, adjusted for age, immigrant status, and coinfection with other high-risk genotypes. No statistically significant associations were found regarding the detected viral variants. A viral load above the median (>1,367.79 copies/cell) was associated with a significant risk of high-grade epithelial lesion or carcinoma, after adjusting for age, immigrant status, coinfections, and viral variant: (adjusted OR 7.89; 95% CI: 2.75–22.68). This relationship showed a statistically significant dose–response pattern after categorizing by viral load tertiles: adjusted OR for a viral load greater than the third tertile was 17.23 (95% CI: 4.20–70.65), with adjusted linear Ptrend = 0.001. In patients infected with HPV16, viral load is associated with high-grade intraepithelial lesions or cervical carcinoma. This could be useful as prognostic biomarker of neoplastic progression and as screening for cervical cancer.
Lactic acid fermentation of vegetables and fruits

Lactic acid (LA) fermentation is considered a simple and useful form of biotechnology to keep and/or enhance the safety, nutritional, sensory and shelf life properties of vegetables and fruits (Demir et al. 2006). As shown in the data from literature of the last decade, the combination of this ancient method of bio-preservation with the current biotechnology tools should allow controlled fermentation processes and the selection of starter cultures to increase the consumption of fresh-like vegetables and fruits (McFeeters 2004, Di Cagno et al. 2013). Lactic acid bacteria (LAB) convert the carbohydrate contents of the vegetables and fruits into LA, which decreases the pH of the fermented products to around 4.0 ensuring stability. Lower pH value restricts the growth of spoilage fl ora and pathogenic bacteria. These bacteria improve the human intestinal microbial balance and enhance health by inhibiting the growth of pathogens such as Escherichia coli, Salmonella and Staphylococcus (Ohmomo et al. 2000, Ross et al. 2002). They are often considered as probiotic, benefi cial for human health and active in lowering the serum cholesterol level (Kaur et al. 2002). They also stimulate immune responses and prevent tumour formation by inhibiting
Genetic parameters for feather weights of breeding ostriches

After the initial decline in value, ostrich feathers have become an integral part of the remuneration of ostrich producers. Categorised (according to the location where it was harvested) mature square-root transformed feather weights depended on gender (males having a 20% higher total feather weight than females) and genotype (South African Black ostriches having a 34% higher total feather weight than Zimbabwean Blues). Animal age interacted with gender, the difference between males and females diminishing from 10 years of age, with no significant gender difference in birds of 11+ years. Heritability estimates of categorised feather weights were low to moderate, and high at 0.30 ± 0.06 for total feather weight. The corresponding value for animal permanent environment amounted to 0.08 ± 0.04. Genetic correlations between categorised feather traits were moderate (0.54 ± 0.16) to very high (0.90 ± 0.10). The present results indicate that feather quantity can be improved by selection in ostriches.
The Effect of Object Selection and Operator Movement on Situation Awareness in Virtual Reality

Virtual reality provides an immersive visual environment that has been used in airborne surveillance tasks. The way in which operators interact with a virtual environment has been seen to influence their situation awareness and physical stress. The present work examines three aspects of interface design within a virtual space: object selection, operator movement, and search method. In two experiments, participants were immersed in a virtual environment and completed a search task and a recall task that mimicked operations seen in airborne surveillance to get measures of situation awareness and physical stress. Additionally, in the second experiment, measures of mental workload were incorporated through a peripheral detection task to examine available cognitive resources. Although all interface designs showed associated advantages and disadvantages, results from the experiments indicated that operator situation awareness and/or physical stress are benefited by a head-gaze selection method, a teleportation movement, and an origin-based search method.
Distributed control for the smart grid with communication constraints and cyber-security

In the last few years networked control systems (NCS) have attracted the attention of the research community due to wide number applications that include communication networks into the feedback control loop to connect spatially distributed elements. Sensor measures and control actions are sent through private or shared communication links, offering many advantages such as reduced system wiring, low installation and maintenance costs, and increase on flexibility and adaption capability. One of the main examples of an NCS is the smart grid, which uses the flow of information of the different states of the power network to take smart decisions and improve reliability and minimize power losses. In this work, we focus our attention on controlling physically isolated elements in the power grid, e.g., microgrids. We propose a control strategy based on the consensus algorithm that uses the frequency information transmitted through the communication network in order to assure frequency synchronization of several isolated microgrids. We use linear and nonlinear models in order to verify the capabilities of our controller, and we show that, under certain conditions, synchronization is achieved independently of the sampling period at which information is transmitted. Sending information through communication channels makes the system vulnerable to cyber-attacks, where an adversary may tamper sensors or actuators in order to access to private information and impact the power system, causing economical losses or even blackouts. A direct consequence of the sampled information property of our proposed controller is data minimization, which allows to improve privacy in the smart grid, and decrease or hide information from adversaries. Moreover, we study false data injection attacks, and we show how some detection mechanisms can minimize the impact of undetected attacks. We study the effects of injecting false information in a higher level control system, i.e., demand response and real time pricing, and we analyze the impact of injecting attacks at a certain frequency using sensitivity analysis. All our results are verified via simulation.
COOPERATIVE SPECTRUM SENSING SCHEME USING FUZZY LOGIC TECHNIQUE

In communication system spectrum has a crucial role and wireless technologies are increasing rapidly it is required to make efficient use of spectrum to satisfy the spectrum scarcity problem. Using spectrum efficiently can be done by cognitive radio because of its ability to sense surrounding environment. Cognitive radio sense unoccupied spectrum by detecting the primary users’ presence or absence in the spectrum. Using more than one cognitive radio in the detection process will increase the efficiency of spectrum usage and prevent interference between signals. Using machine learning techniques for the implementation of intelligent cognitive radio increase efficiency and detection performance and detect signal at low SNR condition. Fuzzy logic machine learning technique is implemented which is based on fuzzy membership functions and fusion centre. Energy detection is used to classify signal and noise at each cognitive radio after that each cognitive radio output information convert into membership function and apply fuzzy rules such as algebraic sum, the algebraic product give a final decision about the signal presence or absence. Simulation results show that the proposed system gives much better results compared to the conventional energy detection system and improves the performance of the system.