Miracle-dz/UniFAR-FTUs huggingface dataset:
The Advantage of Supine and Standing Heart Rate Variability Analysis to Assess Training Status and Performance in a Walking Ultramarathon

Cardiac autonomic modulation of heart rate, assessed by heart rate variability (HRV), is commonly used to monitor training status. HRV is usually measured in athletes after awakening in the morning in the supine position. Whether recording during standing reveals additional information compared to supine remains unclear. We aimed to evaluate the association between short-duration HRV, assessed both in the supine and standing position, and a low-intensity long-duration performance (walking ultramarathon), as well as training experience. Twenty-five competitors in a 100 km walking ultramarathon underwent pre-race supine (12 min) and standing (6 min) HR recordings, whereas performance and subjective training experience were assessed post-race. There were no significant differences in both supine and standing HRV between finishers (n = 14) and non-finishers (n = 11, mean distance 67 km). In finishers, a slower race velocity was significantly correlated with a higher decrease in parasympathetic drive during position change [larger decrease in High Frequency power normalized units (HFnu: r = −0.7, p = 0.01) and higher increase in the detrended fluctuation analysis alpha 1 index (DFA1: r = 0.6, p = 0.04)]. Highly trained athletes accounted for higher HFnu during standing compared to poorly trained competitors (+11.5, p = 0.01). Similarly, greater training volume (total km/week) would predict higher HFnu during standing (r = 0.5, p = 0.01). HRV assessment in both supine and standing position may provide additional information on the dynamic adaptability of cardiac autonomic modulation to physiologic challenges and therefore be more valuable for performance prediction than a simple assessment of supine HRV. Self-reported training experience may reliably associate with parasympathetic drive, therefore indirectly predicting long-term aerobic performance in ultramarathon walking races.
Management of Juvenile Myasthenia Gravis

Juvenile Myasthenia Gravis (JMG) is a rare disorder, defined as myasthenia gravis in children younger than 18 years of age. While clinical phenotypes are similar to adults, there are a number of caveats that influence management: broader differential diagnoses; higher rates of spontaneous remission; and the need to initiate appropriate treatment early, to avoid the long-term physical and psychosocial morbidity. Current practice is taken from treatment guidelines for adult MG or individual experience, with considerable variability seen across centers. We discuss our approach to treating JMG, in a large specialist JMG service, and review currently available evidence and highlight potential areas for future research. First-line treatment of generalized JMG is symptomatic management with pyridostigmine, but early use of immunosuppression, where good control is not achieved is important. Oral prednisolone is used as first-line immunosuppression with appropriate prevention and monitoring of side effects. Second-line therapies including azathioprine and mycophenolate may be considered where there is: no response to steroids, inability to wean to a reasonable minimum effective dose or if side-effects are intolerable. Management of ocular JMG is similar, but requires close involvement of ophthalmology in young children to prevent amblyopia. Muscle-specific tyrosine kinase (MuSK)-JMG show a poorer response to pyridostigmine and anecdotal evidence suggests that rituximab should be considered as second-line immunosuppression. Thymectomy is indicated in any patient with a thymoma, and consideration should be given in acetylcholine receptor (AChR) positive JMG allowing time for spontaneous remission. The benefit is less clear in ocular JMG and is not advised in MuSK-JMG. Children experiencing a myasthenic crisis require urgent hospital admission with access to the intensive care unit. PLEX is preferred over IVIG due to rapid onset of action, but this needs to be balanced with feasibility in very young children. Key questions remain in the management of JMG: when to initiate both first- and second-line treatments, choosing between steroid-sparing agents, and determining the optimal dose and treatment duration. We feel that given the rarity of this disease, the establishment of national registries and collaboration across groups will be needed to address these issues and facilitate future drug trials in JMG.
On a New Species of the Nematode Genus Oswaldocruzia from the Newt

The following description of a new species of the genus Oswaldocruzia is based on the examination of a considerable number of specimens collected from the intestines of 80 newts caught at Aberystwyth. They were found to be equally common in the Smooth Newt (Molge vulgaris Linn.) and the Palmate Newt (Molge palmata Dum. and Bibr.).
Late-Season Common Waterhemp (Amaranthus rudis) Interference in Narrow- and Wide-Row Soybean1

Field studies were conducted in 2000, 2001, and 2002 at Urbana, IL, to examine the interference potential of common waterhemp that emerged at soybean growth stages VE, V2-V3, V4-V5, R1-R2, and R3-R4 in 19- and 76-cm row soybean. Soybean row width and common waterhemp emergence timing significantly influenced common waterhemp density, biomass, seed production, mortality, and soybean yield loss. Common waterhemp density declined as emergence timings were at later soybean growth stages. This decline happened at earlier growth stages in narrow-row soybean. Significant reductions in common waterhemp biomass and seed production occurred at the V2-V3 and V4-V5 emergence timings for the narrow- and wide-row soybean, respectively. Common waterhemp seed production was more than 23,000 seeds per plant at the VE emergence timing for both soybean row widths. Survival of common waterhemp that emerged after the V4-V5 soybean growth stage was less than 20% in both row widths. Common waterhemp interference reduced soybean seed yield at the VE, V2-V3, and the V4-V5 emergence timings. Row width affected the magnitude of yield reductions at these interference timings, with reductions being less in narrow-row soybean. This research suggests that control measures need to be implemented to common waterhemp plants that emerge before V4-V5 soybean to protect soybean yield and reduce common waterhemp seed production. Nomenclature: Common waterhemp, Amaranthus rudis Sauer #3 AMATA; soybean, Glycine max (L.) Merr. ‘Asgrow 3701RR’. Additional index words: Interference, integrated weed management, late-season competition.
Calcification in Hermatypic and Ahermatypic Corals

The evolutionary development of tropical coral reefs is presently ascribed to the association of corals with symbiotic algae (zooxanthellae) and to the enhancement of calcification by light. Contrary to this idea, the calcification rate in a non-reef-building tropical coral (Tubastrea faulkneri) without symbiotic algae was the same as the light-enhanced rate in a zooxanthellate reef-building coral (Galaxea fascicularis). The mechanisms of calcification, however, differed between the two species. Instead of being “light-enhanced,” calcification in corals with algae was “dark-repressed. ” The evolutionary development of coral reefs may therefore not be related to light-enhanced calcification resulting from the association of corals with symbiotic algae.
The Impact of Malaria Parasites on Dendritic Cell–T Cell Interaction

Malaria is caused by apicomplexan parasites of the genus Plasmodium. While infection continues to pose a risk for the majority of the global population, the burden of disease mainly resides in Sub-Saharan Africa. Although immunity develops against disease, this requires years of persistent exposure and is not associated with protection against infection. Repeat infections occur due to the parasite's ability to disrupt or evade the host immune responses. However, despite many years of study, the mechanisms of this disruption remain unclear. Previous studies have demonstrated a parasite-induced failure in dendritic cell (DCs) function affecting the generation of helper T cell responses. These T cells fail to help B cell responses, reducing the production of antibodies that are necessary to control malaria infection. This review focuses on our current understanding of the effect of Plasmodium parasite on DC function, DC-T cell interaction, and T cell activation. A better understanding of how parasites disrupt DC-T cell interactions will lead to new targets and approaches to reinstate adaptive immune responses and enhance parasite immunity.
Accidental Use of Milk With an Increased Concentration of Aflatoxins Causes Significant DNA Damage in Hospital Workers Exposed to Ionizing Radiation

The occupational exposure to ionizing radiation (Irad) or associated with mycotoxin-contaminated food may lead to genome damage and contribute to health risk. DNA damage in 80 blood samples of hospital workers occupationally exposed to low—doses of Irad was compared with 80 healthy controls. Among them, 40 participants accidentally consumed milk with increased concentration of Aflatoxin. All participants underwent the testing for micronuclei from blood, and 40 of them 8-OHdG from urine. The frequency of micronuclei (MN) was analyzed by cytokinesis-block peripheral blood lymphocytes and the level of urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) by ELISA. The Irad led to increased frequency of MN (p < 0.05) and 8-OHdG level at exposed hospital workers. The consumption of milk with increased concentration of aflatoxin probably raised MN frequency and 8-OHdG value. Higher consumption of aflatoxin-contaminated milk (≥2 L/monthly) caused significantly increased MN frequency and 8-OHdG value in comparison to lower milk intake (≤0.5 L/monthly). Also, confounding factors, such as age, gender, and smoking status of all participants were included in the study. The obtained results revealed an increased incidence of MN and 8-OHdG level among hospital workers exposed to low-doses of IRad and milk with increased aflatoxin concentration.
Expertise-Related Differences in Wrist Muscle Co-contraction in Drummers

Background and Aim: Drumming requires excellent motor control and temporal coordination. Deploying specific muscle activation patterns may help achieve these requirements. Muscle activation patterns that involve reciprocal contraction of antagonist muscles are particularly favorable as they enable a high level of muscular economy while maintaining performance. In contrast, simultaneous contraction of antagonist muscles is an inefficient muscle activation pattern. In drumming, co-contraction can lead to increased movement variability and greater fatigue over time. In this study we examine how muscle activation patterns develop with increased drumming expertise. Methods: Eleven expert drummers (ED) and eleven amateur drummers (AD) were recorded using 3D motion capture while performing five different uni-manual and bi-manual repetitive drumming tasks across different tempi. Electromyography was used to record muscle activation of wrist flexor and extensor muscles. Results: Findings indicate that reduced co-contraction resulted in more even drumming performance. Co-contraction also increased in extremely slow and very high tempi. Furthermore, regardless of task or tempo, muscle co-contraction was decreased in participants with higher levels of expertise. In addition to anti-phasic activity of wrist flexor and extensor muscles, expert drummers exhibited a flexor dominance, suggesting more efficient usage of rebound. Conclusion: Taken together, we found that higher levels of drumming expertise go hand in hand with specific muscle activation patterns that can be linked to more precise and efficient drumming performance.
Current Understanding of the Genetics of Intervertebral Disc Degeneration

Premature degeneration of the intervertebral disc and its association with specific chondrodystrophic dog breeds has been recognized for over a century. Several lines of evidence including disease breed predisposition, studies suggesting heritability of premature intervertebral disc degeneration (IVDD) and association of a dog chromosome 12 (CFA 12) locus with intervertebral disc calcification have strongly supported a genetic component in IVDD in dogs. Recent studies documenting association of IVDD with an overexpressing FGF4 retrogene on CFA 12 have opened up new areas of investigation to further define the pathophysiology of premature IVDD. While preliminary data from studies investigating FGF4 retrogenes in IVDD implicate FGF4 overexpression as a major disease factor, they have also highlighted knowledge gaps in our understanding of intervertebral disc herniation which is a complex and multifactorial disease process.
Social Desirability in Environmental Psychology Research: Three Meta-Analyses

That social desirability might be a confounder of people's survey responses regarding environmental actions has been discussed for a long time. To produce evidence for or against this assumption, we conducted meta-analyses of correlations between social desirability scales and self-reports of environmentally relevant behaviors, intentions, and (broadly defined) attitudes, based on data from 29 previously published papers. The pooled correlations with social desirability are generally small, ranging from 0.06 to 0.11 (0.08–0.13 when correcting for measurement error attenuation). However, our results do not lead to the conclusion that social desirability can be completely disregarded by environmental psychologists as a potential confounder. For example, we found evidence of substantial heterogeneity across studies, so the effect of social desirability may be more pronounced in specific cases. Continued attention to social desirability bias is needed to fully understand its possible subtle effects.
The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects

Objective To evaluate whether the nailfold microcirculation is associated with retinal microcirculation in healthy subjects. Methods Fifty subjects without systematic and ocular diseases were enrolled. Thickness of peripapillary retinal nerve fiber layer (RNFL), vessel density (VD) of radial peripapillary capillaries (RPCs), and superficial capillary VD in macular zone were measured with optical coherence tomography angiography (OCTA) in left eyes. Nailfold microcirculation, including capillary density, avascular zones, dilated capillaries, and hemorrhages was examined on the fourth digit of each subject’s non-dominant (left) hand with nailfold capillaroscopy (NFC). Results After adjustment for relatively systemic factors, multivariate regression analyses showed a significant direct relationship between RNFL thickness and nailfold capillary density (OR = 1.09; p = 0.046). RNFL thickness and RPCs VD were negatively correlated with nailfold avascular zones (OR = 0.855; p = 0.007; OR = 0.596; p = 0.010). Superficial VD of parafovea was negatively associated with dilated nailfold capillaries (OR = 0.794; p = 0.012). Conclusion In healthy subjects, nailfold capillary lower density and abnormalities are associated with reduced RNFL thickness and retinal VD. The results provide a theoretical foundation for relevant studies on ocular diseases with microvascular abnormalities and could contribute to pathogenesis understanding in the future. NFC and OCTA have the potential to identify risk factors and improve accuracy of the early diagnosis and treatment of ocular diseases, even systemic diseases with any microvascular component in clinical practice. Clinical Trail Registration http://www.chictr. org.cn/index.aspx, identifier ChiCTR 1800017875.
The Functional Ability of MCI and Alzheimer’s Patients Predicts Caregiver Burden

Research shows that caregivers of dementia patients experience burden and psychological distress, but it is unclear whether or not caregivers of individuals with cognitive impairments that do not meet a diagnosis for dementia also experience similar burdens and psychological problems. Sixty patients and their caregivers participated in this study designed to examine caregiver burden. The patients completed activities-of-daily-living tasks and several neuropsychological tests assessing memory, abstract reasoning, and language. Caregivers completed self-report measures assessing caregiver burden and psychological distress. Results revealed that the caregivers of patients with mild Alzheimer’s disease (mAD) reported greater physical burden and feelings of missing out on life compared to individuals with mild cognitive impairment (MCI) caregivers. The mAD caregivers indicated greater depression and anxiety relative to MCI caregivers. Stepwise regression found that patient neuropsychological scores were worse predictors of caregiver burden than patients’ daily functioning. The conclusions of this study suggest that (1) caregivers of mAD are likely to experience more severe types of burden and psychological distress relative to caregivers of MCI patients, and that (2) patients’ daily functional abilities better predict caregivers’ burden and psychological distress than patients’ neuropsychological functioning. Study findings suggest that caregivers of those in the early stages of dementia, even in persons not yet meeting a diagnosis, experience psychological symptoms and burden, and that these caregivers’ experiences can be best predicted by the patients daily functional ability than by patients’ neuropsychological test scores.
Recovery of High Interference Memory in Spite of Lingering Cognitive Deficits in a Longitudinal Pilot Study of Hospitalized Depressed Patients

Background Major depressive disorder has deleterious impacts on mood, cognition, and many functions of daily life. Even after remission of mood symptoms, patients frequently report persistent cognitive deficits. By contrast, the neurogenic theory of depression posits that recovery from depression is dependent upon a restoration of neurogenesis. The present study was designed to test this prediction by assessing performance in MDD in-patients on a broad battery of cognitive tasks including the Mnemonic Similarity Task, a high interference memory test that is a putative correlate of neurogenesis. We predicted that remitted patients should exhibit recovery of function on this task, even though they may show residual deficits on other cognitive tasks. Methods 18 hospitalized patients diagnosed with MDD and 22 healthy control participants matched for age, sex, and education completed a battery of mood and cognitive tests at two time points. Patients completed their baseline assessments when first admitted to hospital and repeated the same assessments upon remission, typically 4–5 weeks later and just prior to their release from hospital. Control participants were tested at baseline and 4–5 weeks later on the same assessment battery, which included the BDI-II, BAI, Cohen’s PSS, Mnemonic Similarity Task, and several sub-tests adapted from the CANTAB. Results At baseline, MDD patients were impaired relative to controls on the MST and many other cognitive tasks. Upon remission, patients’ MST scores did not differ from those of healthy controls, although patients were still impaired on Pattern Recognition Memory, Spatial Recognition Memory, Delayed Matching to Sample and Paired Associates Learning relative to healthy control participants. Conclusion The lingering memory deficits observed in remitted patients with MDD observed here are broadly consistent with findings in the literature. Importantly, however, remitted patients showed recovery of cognitive function on the Mnemonic Similarity Task. This is the first study that we are aware of to report recovery of function on a high interference, putatively neurogenesis-dependent memory test in a longitudinal sample of hospitalized MDD patients from admission to remission. Our findings are consistent with the neurogenic theory of depression, which posits that a restoration of neurogenesis is linked to recovery from depression.
Identification of Candidate Olfactory Genes in the Antennal Transcriptome of the Stink Bug Halyomorpha halys

The brown marmorated stink bug, Halyomorpha halys (Hemiptera: Pentatomidae), is a serious agricultural and urban pest that has become an invasive species in many parts of the world. Olfaction plays an indispensable role in regulating insect behaviors, such as host plant location, partners searching, and avoidance of predators. In this study, we sequenced and analyzed the antennal transcriptomes of both male and female adults of H. halys to better understand the olfactory mechanisms in this species. A total of 241 candidate chemosensory genes were identified, including 138 odorant receptors (ORs), 24 ionotropic receptors (IRs), 15 gustatory receptors (GRs), 44 odorant-binding proteins (OBPs), 17 chemosensory proteins (CSPs), and three sensory neuron membrane proteins (SNMPs). The results of semi-quantitative reverse transcription PCR (RT-PCR) assays showed that some HhalOBP and HhalCSP genes have tissue-specific and sex-biased expression patterns. Our results provide an insight into the molecular mechanisms of the olfactory system in H. halys and identify potential novel targets for pest control strategies.
No Bilingual Benefits Despite Relations Between Language Switching and Task Switching

Previous research has shown that bilingual children outperform monolinguals on tasks testing cognitive control. Bilinguals’ enhanced cognitive control is thought to be caused by the necessity to exert more language control in bilingual compared to monolingual settings. Surprisingly, between-group research of cognitive effects of bilingualism is hardly ever combined with within-group research that investigates relationships between language control and cognitive control. The present study compared 27 monolingual Dutch and 27 bilingual Turkish-Dutch children matched on age and fluid intelligence on their performance in a nonverbal switching task. Within the group of bilinguals, the relationship between nonverbal switching and language switching was examined. The results revealed no between-group differences on nonverbal switching. Within the bilingual sample, response times in the language switching and nonverbal switching tasks were related, although no relationships were found between accuracy, switching cost and mixing cost on both tasks. The results support the hypothesis that children utilize domain-general cognitive control in language switching, but this relationship does not entail that bilinguals have better cognitive control than monolinguals.