Miracle-dz/UniFAR-FTUs huggingface dataset:
Low risk of acquiring melioidosis from the environment in the continental United States

Melioidosis is an underreported human disease of tropical and sub-tropical regions caused by the saprophyte Burkholderia pseudomallei. Although most global melioidosis cases are reported from tropical regions in Southeast Asia and northern Australia, there are multiple occurrences from sub-tropical regions, including the United States (U.S.). Most melioidosis cases reported from the continental U.S. are the result of acquiring the disease during travel to endemic regions or from contaminated imported materials. Only two human melioidosis cases from the continental U.S. have likely acquired B. pseudomallei directly from local environments and these cases lived only ~7 km from each other in rural Texas. In this study, we assessed the risk of acquiring melioidosis from the environment within the continental U.S. by surveying for B. pseudomallei in the environment in Texas where these two human melioidosis cases likely acquired their infections. We sampled the environment near the homes of the two cases and at additional sampling locations in surrounding counties in Texas that were selected based on ecological niche modeling. B. pseudomallei was not detected at the residences of these two cases or in the surrounding region. These negative data are important to demonstrate that B. pseudomallei is rare in the environment in the U.S. even at locations where locally acquired human cases likely have occurred, documenting the low risk of acquiring B. pseudomallei infection from the environment in the continental U.S.
The intersection of immigration policy impacts and COVID‐19 for Latinx young adults

Abstract For many Latinx young adults, COVID‐19 has exposed exclusionary policies that heighten risk for contracting the virus and that leave them and their parents unprotected. This study has a dual purpose; first, to quantitatively examine immigration policy impacts of discrimination, isolation, threats to family, and vulnerability, and their association to economic consequences experienced by Latinx young adults in Central Texas during the initial months of the COVID‐19 pandemic. Second, to qualitatively explore how policy impacts affected Latinx young adults during the pandemic, and the coping mechanisms they utilized to minimize these impacts. Quantitative results show that on average, Latinx young adults (N = 83) reported low discrimination and isolation but moderate threats to family and vulnerability, with rates of isolation and vulnerability higher for foreign‐born than U.S.‐born Latinx young adults. Perceived discrimination due to one's own or family immigration status was associated with economic hardship. Qualitative findings show that Latinx young adults (n = 21) experienced (a) precarious conditions that pose a threat of COVID‐19 infection for Latinxs, (b) parental job loss due to vulnerable employment leads to deprivation, and (c) policies that disproportionally discriminate against the Latinx community and exclude them from vital services. Despite these challenges, participants also drew on resilience and expressed hope for the future. The article concludes with implications for policymakers and practitioners to provide protections and services to Latinx young adults and their family members.
Exposure to Outdoor Tobacco Advertisements Near Home is Associated with Smoking among Youth in Indonesia

Background: The prevalence of cigarette smoking among adults is persistently high, and among youth is increasing in Indonesia. Objective: This study aims to examine the association between youth smoking behavior and outdoor tobacco adverts near home in Indonesia. Methods: We conducted a cross-sectional survey of 3,557 students in North Sumatera during September-November 2020. The main independent variables include seeing tobacco advertisements near home, near school, on social media. The outcome variables included ever smoked and smoked in the last ten days. Results: We found significant associations between exposure to outdoor tobacco adverts near home and youth smoking. High school students who reported seeing tobacco adverts near home were 1.42 times more likely to smoke and 2.29 times more likely to smoke in the last ten days. Moreover, students at private schools (a proxy for higher income) exposed to tobacco adverts near home were 1.56 times more likely to smoke and 2.93 times more likely to smoke in the last ten days. Conclusion: Exposure to outdoor tobacco advertisements near home is associated with smoking among youth in Indonesia. Comprehensive tobacco control efforts are needed, including through a ban of outdoor tobacco adverts.
The FIFA 11+ Kids Injury Prevention Program Reduces Injury Rates Among Male Children Soccer Players: A Clustered Randomized Controlled Trial

Background: The Fédération Internationale de Football Association (FIFA) 11+ Kids is an exercise-based injury prevention program developed by an international group of experts to prevent injuries among child soccer players. Hypothesis: It was hypothesized that the FIFA 11+ Kids program would be more effective than performing a typical warm-up regimen in reducing overall injuries among soccer players aged 7 to 13 years. Study Design: A clustered randomized controlled trial. Level of Evidence: Level 1. Methods: A total of 94 boys’ soccer teams, including 780 players, were randomly allocated into an experimental or control group. Complete datasets were collected from 45 teams (377 players) and 43 teams (363 players) in the experimental and control groups, respectively. The experimental group underwent the FIFA 11+ Kids program as a warm-up during training sessions and matches at least twice a week, and the control group continued performing their usual warm-ups. Participants were prospectively followed during 1 season (6 months). The primary outcomes included the incidence of overall and recurrent injuries and their mechanism and severity. The secondary outcome was the rate of compliance with the intervention program. Results: A total of 43 injuries were reported in the experimental group in 50,120 hours of exposure (0.85 injuries/1000 exposure hours). A total of 86 injuries were reported in the control group in 42,616 hours of exposure (2.01 injuries/1000 exposure hours). The injury risk ratio was 0.43 (0.29-0.61), suggesting that the experimental group experienced 57% fewer injuries than those in the control group. Conclusion: The FIFA 11+ Kids program reduced overall injury rates in children playing soccer more than the usual warm-ups. Clinical Relevance: The results of this study provide evidence for children’s coaches to consider including the FIFA 11+ Kids program in their warm-up regimen. Such a program may prevent injury risk and decrease absenteeism and injury-related financial burdens.
Modifiable (Sleeping Pattern and Stress) and Non-Modifiable Risk Factors Associated with Breast Cancer: A Matched Case-Control Study in Delhi, India

Background: An utmost increase of breast cancer burden during the last several decades was reported in Asian countries. Findings from literature confirm that risk factors of breast cancers can be modifiable and non-modifiable in nature. Objective: The present study is designed to identify specific modifiable and non-modifiable risk factors associated with breast cancer. Methods: A matched case-control study was conducted considering 187 cases as women diagnosed with breast cancer and 187 hospital-controls as women without having breast cancer visiting the hospital. Other than standard risk factors, stress is measured using Perceived Stress Scale (PSS) and stress is measured using Pittsburgh Sleep Quality Index (PSQI). Several modifiable and non-modifiable risk factors were assessed using conditional logistic regression to find out significant association with breast cancer. Results: Regular multi-vitamin uptake (OR = 3.38; 95%CI = 1.69 – 6.77; p-value = 0.001), poor sleep (OR = 11.29; 95%CI = 4.36 – 29.25; p-value < 0.001), irregular sleep (OR = 34.11; 95%CI = 10.03 – 115.92; p-value < 0.001) and severe stress (OR = 6.74; 95%CI = 3.06 – 14.81; p-value < 0.001) were found to be the highest odds ratio among all modifiable risk factor of breast cancer. Also, age at first childbirth less than 30 years (OR = 0.44; 95%CI = 0.25 – 0.78; p-value = 0.005) was found protective against breast cancer. Conclusion: In our study, stress, sleeping pattern, and regular multi-vitamin uptake were found to be significant modifiable risk factors of breast cancer. None of the non-modifiable risk factors were found to be significantly associated with the risk of breast cancer.
Identification of a novel deFADding activity in human, yeast and bacterial 5′ to 3′ exoribonucleases

Abstract Identification of metabolite caps including FAD on the 5′ end of RNA has uncovered a previously unforeseen intersection between cellular metabolism and gene expression. To understand the function of FAD caps in cellular physiology, we characterised the proteins interacting with FAD caps in budding yeast. Here we demonstrate that highly conserved 5′-3′ exoribonucleases, Xrn1 and Rat1, physically interact with the RNA 5′ FAD cap and both possess FAD cap decapping (deFADding) activity and subsequently degrade the resulting RNA. Xrn1 deFADding activity was also evident in human cells indicating its evolutionary conservation. Furthermore, we report that the recently identified bacterial 5′-3′ exoribonuclease RNase AM also possesses deFADding activity that can degrade FAD-capped RNAs in vitro and in Escherichia coli cells. To gain a molecular understanding of the deFADding reaction, an RNase AM crystal structure with three manganese ions coordinated by a sulfate molecule and the active site amino acids was generated that provided details underlying hydrolysis of the FAD cap. Our findings reveal a general propensity for 5′-3′ exoribonucleases to hydrolyse and degrade RNAs with 5′ end noncanonical caps in addition to their well characterized 5′ monophosphate RNA substrates indicating an intrinsic property of 5′-3′ exoribonucleases.
Differential contributions of cardiac, coronary and pulmonary artery vagal mechanoreceptors to reflex control of the circulation

Distinct populations of stretch‐sensitive mechanoreceptors attached to myelinated vagal afferents are found in the heart and adjoining coronary and pulmonary circulations. Receptors at atrio‐venous junctions appear to be involved in control of intravascular volume. These atrial receptors influence sympathetic control of the heart and kidney, but contribute little to reflex control of systemic vascular resistance. Baroreceptors at the origins of the coronary circulation elicit reflex vasodilatation, like feedback control from systemic arterial baroreceptors, as well as having characteristics that could contribute to regulation of mean pressure. In contrast, feedback from baroreceptors in the pulmonary artery and bifurcation is excitatory and elicits a pressor response. Elevation of pulmonary arterial pressure resets the vasomotor limb of the systemic arterial baroreflex, which could be relevant for control of sympathetic vasoconstrictor outflow during exercise and other states associated with elevated pulmonary arterial pressure. Ventricular receptors, situated mainly in the inferior posterior wall of the left ventricle, and attached to unmyelinated vagal afferents, are relatively inactive under basal conditions. However, a change to the biochemical environment of cardiac tissue surrounding these receptors elicits a depressor response. Some ventricular receptors respond, modestly, to mechanical distortion. Probably, ventricular receptors contribute little to tonic feedback control; however, reflex bradycardia and hypotension in response to chemical activation may decrease the work of the heart during myocardial ischaemia. Overall, greater awareness of heterogeneous reflex effects originating from cardiac, coronary and pulmonary artery mechanoreceptors is required for a better understanding of integrated neural control of circulatory function and arterial blood pressure.
Wayfinding in Children: A Descriptive Literature Review of Research Methods

Abstract Wayfinding refers to the process of locating unseen destinations in the spatial environment and is an important spatial skill for children. Despite a growing interest in wayfinding development in children, less attention has been focused on documenting the vast methodological heterogeneity of the existing research body, which impacts the ability to synthesize results across different studies. This review aims to systematically catalog and examine the research methods of the wayfinding development literature. We identified a total of 96 studies that examined 4- to 16- year-old children’s wayfinding of unfamiliar, large-scale environments and were published between 1965 and 2020. Based on the environments, we grouped these studies into virtual reality (VR) vs. real-life and indoor vs. outdoor. The review revealed a vast diversity in research methods regarding participants, environments, independent variables (IVs), environmental exposure, dependent variables (DVs), and cognitive/behavioral correlates. The field has seen growing research interests in VR environments and atypical development. The most common IVs focused on the environmental features of landmarks and turn information. Relatively less research considered how different cognitive processes such as attention, memory, and learning contribute to wayfinding. Various outcome measures have been used to investigate landmark, route, and survey knowledge regarding DVs. This review showed an imbalance of topic areas in the field, systematic differences between different types of studies, and the need for greater attention on a number of important topics. Finally, we provided targeted, detailed recommendations for future research.
Comparison of reproductive outcomes in subclinical hypothyroidism women with high‐normal versus low‐normal thyroid‐stimulating hormone levels after treatment with levothyroxine

Reproductive outcomes in euthyroid women with high‐normal thyroid‐stimulating hormone (TSH) levels are comparable to those in euthyroid women with low TSH levels; however, few studies have investigated whether strictly controlled TSH levels after levothyroxine (LT4) treatment impair reproductive outcomes in infertile women with subclinical hypothyroidism (SCH). This study aimed to investigate the impact of high‐normal versus low‐normal TSH levels on reproductive outcomes in women undergoing their first in vitro fertilisation and embryo transfer (IVF‐ET) cycle.
PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia

Chemotherapy induces a cachectic‐like phenotype, accompanied by skeletal muscle wasting, weakness and mitochondrial dysfunction. Peroxisome proliferator‐activated receptor‐gamma coactivator‐1 alpha (PGC1α), a regulator of mitochondrial biogenesis, is often reduced in cachectic skeletal muscle. Overexpression of PGC1α has yielded mixed beneficial results in cancer cachexia, yet investigations using such approach in a chemotherapy setting are limited. Utilizing transgenic mice, we assessed whether overexpression of PGC1α could combat the skeletal muscle consequences of cisplatin.
Exotic fishes that are phylogenetically close but functionally distant to native fishes are more likely to establish

Since Darwin's time, degree of ecological similarity between exotic and native species has been assumed to affect the establishment success or failure of exotic species. However, a direct test of the effect of exotic–native similarity on establishment of exotics is scarce because of the difficulty in recognizing failures of species to establish in the field. Here, using a database on the establishment success and failure of exotic fish species introduced into 673 freshwater lakes, we evaluate the effect of similarity on the establishment of exotic fishes by combining phylogenetic and functional information. We illustrate that, relative to other biotic and abiotic factors, exotic–native phylogenetic and functional similarities were the most important correlates of exotic fish establishment. While phylogenetic similarity between exotic and resident fish species promoted successful establishment, functional similarity led to failure of exotics to become established. Those exotic species phylogenetically close to, but functionally distant from, native fishes were most likely to establish successfully. Our findings provide a perspective to reconcile Darwin's naturalization conundrum and suggest that, while phylogenetic relatedness allows exotic fish species to pre‐adapt better to novel environments, they need to possess distinct functional traits to reduce competition with resident native fish species.
Untargeted plasma metabolomics for risk prediction of hepatocellular carcinoma: A prospective study in two Chinese cohorts

Characterization of metabolic perturbation prior to hepatocellular carcinoma (HCC) may deepen the understanding of causal pathways and identify novel biomarkers for early prevention. We conducted two 1:1 matched nested case‐control studies (108 and 55 pairs) to examine the association of plasma metabolome (profiled using LC‐MS) with the risk of HCC based on two prospective cohorts in China. Differential metabolites were identified by paired t tests and orthogonal partial least‐squares discriminant analysis (OPLS‐DA). Weighted gene coexpression network analysis (WGCNA) was performed to classify metabolites into modules for identifying biological pathways involved in hepatocarcinogenesis. We assessed the risk predictivity of metabolites using multivariable logistic regression models. Among 612 named metabolites, 44 differential metabolites were identified between cases and controls, including 12 androgenic/progestin steroid hormones, 8 bile acids, 10 amino acids, 6 phospholipids, and 8 others. These metabolites were associated with HCC in the multivariable logistic regression analyses, with odds ratios ranging from 0.19 (95% confidence interval [CI]: 0.11‐0.35) to 5.09 (95% CI: 2.73‐9.50). WGCNA including 612 metabolites showed 8 significant modules related to HCC risk, including those representing metabolic pathways of androgen and progestin, primary and secondary bile acids, and amino acids. A combination of 18 metabolites of independent effects showed the potential to predict HCC risk, with an AUC of 0.87 (95% CI: 0.82‐0.92) and 0.86 (95% CI: 0.80‐0.93) in the training and validation sets, respectively. In conclusion, we identified a panel of plasma metabolites that could be implicated in hepatocellular carcinogenesis and have the potential to predict HCC risk.
Multispectral polarized BRDF: design of a highly resolved reflectometer and development of a data inversion method

Multispectral and polarized light reflectance measurements are very useful to characterize materials such as paint coatings. This article presents an overview of an automated high-angular resolved, in-plane multispectral polarized reflectometer and its calibration process. A comprehensive study based on multispectral BRDF and DOLP measurements is conducted on different colour and glossy aspects of paint coatings. An original inverse method from in-plane measurements is used to model the out-of-plane BRDF and to investigate the role of the surface and subsurface scattering phenomena in its components.
Temperature measurement: Must it be the forehead? A prospective cross-sectional study.

BACKGROUND The aim of this study was to compare temperature readings measured at the forehead and wrist against the tympanic temperature which is generally accepted as the standard. METHOD This is a cross-sectional study carried out on 325 people from the general population entering a private hospital for consultation or work. Forehead and wrist temperature was taken using the CEFC RoHS K3 model (China) and tympanic temperature using the Braun Thermoscan 7 Thermometer Irt6520 by the same investigator on consenting individuals. RESULTS There was no significant difference between the forehead (mean =36.6, standard deviation, SD=0.30) and tympanic (mean=36.6, SD=0.41), Z= -1.609, p=0.108. However, there was significant difference between the wrist (mean=36.4, SD= 0.28) and tympanic (mean=36.6, SD=0.41) temperature values, Z= -8.749, p<0.001, the former being lower. Temperature measured at forehead (mean=36.6, SD=0.30) was also significantly higher than the wrist (mean=36.4, SD=0.28), Z= -9.381, p<0.001. The wrist temperature values were lower than forehead and tympanic. CONCLUSION Forehead temperature values are better representatives of the core temperature (tympanic) and be the preferred site of measurement compared to the wrist.
A cross-cultural study of visual attention in autism spectrum disorder

ABSTRACT Differences in visual attention have been documented in ASD, and appear linked to clinical symptoms. However, most research has been conducted in Western cultures. Because striking differences in visual attention patterns have been documented in other cultures, it is important to understand how culture may influence attentional patterns in ASD. This study compared differences in visual attention in ASD across Western and East Asian cultures, where differences in attention to contextual and global information have been repeatedly demonstrated, to investigate potential culturally-specific ASD phenotypes. One hundred thirty-two total participants included individuals with ASD (n = 24) and controls (n = 47) from Hong Kong (HK), along with a previously studied group of age- and IQ-comparable participants from the United States (n = 26 ASD; n = 35 control). Gaze was tracked while participants completed two narrative tasks that differed in social-emotional complexity. Proportions of fixations to face, bodies, and setting were examined across groups using linear mixed-effect models and a series of growth curve models. Cultural differences were found across tasks and groups. Both the ASD and control HK groups attended more to global contextual setting information, more to the body regions, and less toward faces of characters compared to US groups. Growth curve models indicated that these differences attenuated over time in certain stimuli. ASD-related effects were only observed in the more complex stimuli depicting characters with ambiguous facial expressions. Findings indicate a notable cultural influence on visual attention patterns in ASD, and underscore the importance of stimuli complexity in differentiating cultural versus diagnostic effects on attentional styles.
A Further Exploration of Some Computational Issues in Equilibrium Business Cycle Theory: Discussion Paper No. 136

This paper revisits some of the issues involved in the comparison of alternative computational procedures within the context of a dynamic stochastic general equilibrium model. The framework in question is a more general one, in which a “standard‿ or relatively simple model is nested as a special case. Results of numerical experiments suggest that different computational methods may be used interchangeably in the case of the standard model, but not in the case of the more general model. Varying a preference parameter allows us to compare what happens to solutions using alternative procedures as one moves away from the special case to the more general framework. On the basis of the numerical experiments conducted, we find that not only do differences in solutions become larger, but answers to several economic issues of interest can yield qualitatively different answers depending on the solution method used. Examples of such issues include how second moment features change as one varies the parameters of a model, and the relative contribution of different types of stochastic shocks to fluctuations in variables.