Miracle-dz/UniFAR-FTUs huggingface dataset:
Profitability and resource-use efficiency of sugarcane production in Nawalparasi west district, Nepal

Abstract The study was undertaken to assess the profitability and resource-use efficiency of sugarcane producers in Nawalparasi West district, Nepal. The primary data were collected from 135 sugarcane farmers’ personal interview. Cost and return analysis and Cobb-Douglas production function were used for analysis. The B:C ratio of main crop was found 1.02 and ratoon crop was 2.08, whereas overall B:C was 1.35. Labor, setts, irrigation and nutrient were found to have significant and positive effect on gross return of sugarcane. Furthermore, labor and tillage hour were found to be over-utilized whereas irrigation, nutrient and setts were found to be underutilized. Insufficiency and unavailability of chemical fertilizer, absence of irrigation and drainage facilities and unavailability of quality setts were reasons for underutilization. Assurance of availability and affordability of setts, fertilizers, irrigation and intervention of modern-integrated agro-machineries can play significant role for efficient use of resources. Moreover, subsidy on inputs and mechanization are recommended to reduce the cost of production and maximize the profit.
Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype

Social dysfunctions (SD) are frequently observed in subjects with schizophrenia. Some of these dysfunctions are also observed in other neuropsychiatric disorders such as autism spectrum disorders (ASD), major depression, bipolar disorder, or Alzheimer disease. Recently, a characterization of a specific type of SD in schizophrenia has been proposed, with the concept of dis-sociality, which form the core aspect of “Schizophrenic Autism” (SA). The present study aimed to explore the presence in people with schizophrenia of SA, independent of other autistic traits, which can be often found in schizophrenia and other neurodevelopmental disorders. We used a structured interview—the Autism Rating Scale (ARS), an instrument devised to detect and measure SA. Fifty-one outpatients affected by schizophrenia (26 remitted, SCZ-r) and 28 affected by bipolar disorder type 1, with psychotic features, in the euthymic phase (BD-e) were recruited. Before assessing the specificity for schizophrenia of SA, we tested the internal consistency, the convergent and divergent validity of the ARS in the schizophrenia sample. Specificity was assessed by examining potential differences in ARS scores between SCZ-r and BD-e subjects. ARS showed good internal consistency, as well as convergent and divergent validity. ARS items were more frequently of moderate severity in SCZ-r than in BD-e subjects. This scale can contribute to establish more precise phenomenal boundaries between schizophrenia and bipolar disorder, and opens up the possibility of identifying a different type of SD in schizophrenia, independent of autistic traits and negative symptoms, which might benefit from different treatments.
Digital Articulation: Examining Text-Based Linguistic Performances in Mobile Communication Through Keystroke-Logging Analysis

This study examines how text-based mobile communication practices are performatively constructed as individuals compose messages key-by-key on virtual keyboards, and how these synchronous performances (Mobile interface theory: embodied space and locative media. New York, NY: Routledge) reflect the iterative process of constructing and maintaining interpersonal relationships. In doing so, this study reports on keystroke-logging analysis (see Writ. Commun. 30, 358–392) in order to observe how participants (N = 10) composed text as part of everyday mobile communication for the period of one week, subsequently producing 179,996 individual keystroke log-file records. Participants used LogKey, a virtual keyboard application made exclusively for this study to run on the Android mobile operating system. Analysis of keystroke log-file data suggest that timing processes of composing text-messages may differ as participants messaged with different categories of interlocutors, composed on different communication applications, and composed paralinguistic features—such as variants of Lol and Haha Thurlow and Brown, (Discourse Anal. Online, 2003, 1, 1); Tagg, (Discourse of text messaging. 2012, Bloomsbury, UK)—at different turn-taking positions. This evidence suggests that keystroke-logging methods may contribute to understanding of how individuals manage interpersonal relationships in real-time (Please reply! the replying norm in adolescent SMS communication,” in The inside text: social, cultural and design perspectives on SMS. (Norwell, MA: Springer), 53–73); (Beyond genre: closings and relational work in texting,” in Digital discourse: language in the new media. (Oxford: Oxford University Press), 67–85), and suggests future direction for methodologically studying linguistic performances as part of text-based mobile communication.
Impaired Learning From Errors and Punishments and Maladaptive Avoidance—General Mechanisms Underlying Self-Regulation Disorders?

Self-regulation (SR) is an important human function that relates to quality of life in multiple domains including mental health. Previous studies have found important correlates of low SR including impulsivity and poor emotional regulation; however, underpinnings of low SR are incompletely understood. Individuals low in SR frequently engage in maladaptive behaviors (substance abuse, procrastination, etc.) despite negative consequences. This phenomenon suggests that impaired learning from errors and punishments may be important mechanisms underlying low SR. Consistently, previous studies observed impaired error processing in a wide spectrum of individuals with low SR and impaired learning from errors and punishments in SR-related disorders. We also note a possible role for poor emotional regulation and refer to concepts suggesting that engaging in maladaptive behaviors may serve as short term emotion regulation strategies aimed at avoiding or alleviating negative affect. We speculate on transdiagnostic factors underlying poor SR. We propose that impaired error processing (possibly related to striatal functioning) may prevent subjects with low SR from learning from errors and punishments and thus learning better SR skills or tendencies. Additionally, impaired coping in emotionally challenging situations, possibly related to prefrontal-cortical functioning, may lead to maladaptive avoidance. Moreover, maladaptive behaviors may be reinforced by the temporary decreases in negative affect and rewarding values of behaviors. Given existing knowledge gaps, we call for more extensive research and describe possible directions and challenges for future studies.
Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma

The airway epithelium is the primary site where inhaled and resident microbiota interacts between themselves and the host, potentially playing an important role on allergic asthma development and pathophysiology. With the advent of culture independent molecular techniques and high throughput technologies, the complex composition and diversity of bacterial communities of the airways has been well-documented and the notion of the lungs' sterility definitively rejected. Recent studies indicate that the microbial composition of the asthmatic airways across the spectrum of disease severity, differ significantly compared with healthy individuals. In parallel, a growing body of evidence suggests that bacterial viruses (bacteriophages or simply phages), regulating bacterial populations, are present in almost every niche of the human body and can also interact directly with the eukaryotic cells. The triptych of airway epithelial cells, bacterial symbionts and resident phages should be considered as a functional and interdependent unit with direct implications on the respiratory and overall homeostasis. While the role of epithelial cells in asthma pathophysiology is well-established, the tripartite interactions between epithelial cells, bacteria and phages should be scrutinized, both to better understand asthma as a system disorder and to explore potential interventions.
Gratitude and Adaptive Coping Among Chinese Singaporeans During the Beginning of the COVID-19 Pandemic

We report results of a cross-sectional survey conducted during March–April 2020 which marked the start and escalation of the COVID-19 crisis in Singapore. Our purpose was to examine whether reported feelings of gratitude among Chinese Singaporeans (N = 371; 124 males, 247 females; Mage = 22.54, SDage = 3.63, age range: 18–53 years) could be linked to adaptive responses to the pandemic. The results revealed that gratitude was associated with stronger endorsement of virus-prevention measures (β = 0.25, p = 0.001) that are necessary for protecting the physical health of oneself and others but disruptive to daily lives. Gratitude was also positively related to the tendency to perceive meaningful benefits in the crisis (β = 0.25, p = 0.002). Importantly, demonstrating the uniqueness and robustness of gratitude as a predictor of positive coping in response to the pandemic, these relationships remained significant when controlling for other protective psychological factors (resilience and optimism), emotions, and key demographic variables. Among the emotions measured, gratitude was also reported the most strongly. The findings support theoretical models that gratitude facilitates prosocial inclinations and openness to different ways to support the well-being of others and suggest that in a collectivistic culture, gratitude could be a key resource enabling adaptation to a crisis.
Eating Disorder Symptoms in Elite Spanish Athletes: Prevalence and Sport-Specific Weight Pressures

We determined the prevalence of eating disorder (ED) symptoms among elite Spanish athletes from a broad range of sports and levels of competition and examined the associations between the presence of symptoms and perceived sport-specific weight pressures. We surveyed 646 elite athletes (16.7 ± 4.4 years; 51.08% females) representing 33 sports from top-division teams and two elite athlete training centers in Catalonia. Based on the results of the Eating Attitudes Test-26 responses, 5.1% of athletes (7.6% of females and 2.5% of males) were at risk of EDs. The highest rates of ED symptoms were observed in male endurance athletes and female esthetic athletes. Competition level was not a risk factor. The only gender differences in the presence of ED symptoms by competing level were observed in athletes competing at the national level. Female athletes with ED symptoms scored higher on the two subscales of the Spanish version of the Weight Pressures in Sport (WPS) tool: coach and sport-specific pressures and pressures from teammates and due to uniform. Male athletes with ED symptoms scored higher on the pressures due to uniform subscale. Finally, symptomatic female but not male athletes competing at international and national levels also perceived greater sport-specific weight pressures.
Long-Term Risk Factors for Intracranial In-Stent Restenosis From a Multicenter Trial of Stenting for Symptomatic Intracranial Artery Stenosis Registry in China

Background: For patients with symptomatic intracranial artery stenosis (sICAS), endovascular treatment has been shown to be feasible and safe in recent studies. However, in-stent restenosis (ISR) risks the recurrence of ischemic stroke. We attempt to elucidate the risk factors for ISR. Methods: We retrospectively analyzed 97 patients with sICAS from a prospective registry trial that included 20 centers from September 2013 to January 2015. Cases were classified into the ISR≥ 50% group or the ISR < 50% group. The baseline characteristics and long-term follow-up were compared between the two groups. Binary logistic regression analyses were identified as an association between ISR and endovascular technique factors. Results: According to whether ISR was detected by CT angiography, 97 patients were divided into the ISR group (n = 24) and the non-ISR group (n = 73). The admission baseline features and lesion angiography characteristics were similar, while plasma hs-CRP (mg/L) was higher in the ISR≥ 50% group at admission (8.2 ± 11.4 vs. 2.8 ± 4.1, p = 0.032). Binary logistic regression analysis identified the longer stents (adjusted OR 0.816, 95% CI 0.699–0.953; p = 0.010), balloon-mounted stents (adjusted OR 5.748, 95% CI 1.533–21.546; p = 0.009), and local anesthesia (adjusted OR 6.000, 95% CI 1.693–21.262; p = 0.006) as predictors of ISR at the 1-year follow-up. Conclusions: The longer stents, balloon-mounted stents implanted in the intracranial vertebral or basilar artery, and local anesthesia were significantly associated with in-stent restenosis. Further studies are required to identify accurate biomarkers or image markers associated with ISR in ICAS patients. Clinical Trial Registration: www.ClinicalTrials. gov, identifier: NCT01968122.
Reverse Engineering and Robotics as Tools for Analyzing Neural Circuits

Understanding neuronal circuits that have evolved over millions of years to control adaptive behavior may provide us with alternative solutions to problems in robotics. Recently developed genetic tools allow us to study the connectivity and function of the insect nervous system at the single neuron level. However, neuronal circuits are complex, so the question remains, can we unravel the complex neuronal connectivity to understand the principles of the computations it embodies? Here, I illustrate the plausibility of incorporating reverse engineering to analyze part of the central complex, an insect brain structure essential for navigation behaviors such as maintaining a specific compass heading and path integration. I demonstrate that the combination of reverse engineering with simulations allows the study of both the structure and function of the underlying circuit, an approach that augments our understanding of both the computation performed by the neuronal circuit and the role of its components.
Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis

Introduction Basal cell carcinoma (BCC) located on the genitalia is rare; data on the clinicopathologic features and survival outcomes are only available through case reports and small case series studies. Purpose This study aimed to explore the epidemiology and identify the prognostic factors of genital BCCs. Methods We queried the 18 registries of the Surveillance, Epidemiology, and End Results database for patients with primary BCCs of the genital skin from 2000 through 2017. The primary endpoint was overall survival (OS) and disease specific survival (DSS). Kaplan-Meier survival analysis was conducted to assess the impact of clinicopathological variables on OS and DSS. Multivariate Cox proportional hazards model was performed to evaluate risk factors for OS. Results A total of 1,607 cases of genital BCCs were identified. The cohort was composed of 1,352 women (84.1%) and 255 men (15.9%). The median (P25, P75) age of the entire cohort was 73(63–82)years. White patients accounted for 87.2% of the cases. For women and men, the most common site of involvement was the labia majora (89.6%) and scrotum (74.5%), respectively. The majority of patients with genital BCC had localized disease (75.5%). Kaplan-Meier survival analysis showed that female genital BCCs experienced better DSS than men (209.1 months vs 194.8 months); for men, BCCs located on the scrotum had better DSS and OS than those on the penis (P < 0.05 for both endpoints). All patients with distant disease died of disease-specific death, and the average survival time was 8.2 months. Multivariate analysis revealed that age, primary site, and stage were independent determinants of OS for men, while tumor size, histologic subtype, and race were not. For women, factors associated with worse OS included increasing age, tumor size more than 2 cm, and distant disease; factors associated with a decreased risk included “other” and “unknown” races. Conclusion The prognosis of genital BCCs is excellent, while the survival of distant disease is very poor. Despite similar clinicopathologic features and overall survival outcomes, men and women should be treated as two different entities when making survival predictions.
Coronavirus Disease Stress Among Italian Healthcare Workers: The Role of Coping Humor

The study aimed to understand how coping strategies in general and humor-based coping strategies in particular modulate the perception of pandemic-related stress in a sample of Italian healthcare workers during the coronavirus disease (COVID-19) outbreak in Italy. A total of 625 healthcare workers anonymously and voluntarily completed a 10-min questionnaire, which included psychometrically valid measurements preceded by a set of questions aimed at determining workers’ exposure to COVID-19. The Perceived Stress Scale was used to measure healthcare workers’ stress levels, and the Brief COPE Scale and Coping Humor Scale were used to assess participants’ avoidant or approach coping style and verify the degree to which they relied on humor to cope with stress. The results show that (1) levels of perceived stress were higher in healthcare workers who were more exposed to COVID-19 (i.e., who came into contact with COVID-19 patients or worked in wards dedicated to COVID-19) in comparison to less-exposed workers; (2) participants who reported a higher use of avoidant coping strategies perceived the situation as more stressful than those who used them less; and (3) healthcare workers who reported higher use of humor-based coping strategies perceived the situation as less stressful in comparison with those who reported less use of coping humor. Such findings expanded other research studies by including coping humor as a potential factor to mitigate the perceived stress related to COVID-19. The paper concludes with a discussion of implications for future research and limitations of the study.
Less is More/More Diverse: On The Communicative Utility of Linguistic Conventionalization

We present empirical evidence of the communicative utility of conventionalization, i.e., convergence in linguistic usage over time, and diversification, i.e., linguistic items acquiring different, more specific usages/meanings. From a diachronic perspective, conventionalization plays a crucial role in language change as a condition for innovation and grammaticalization (Bybee, 2010; Schmid, 2015) and diversification is a cornerstone in the formation of sublanguages/registers, i.e., functional linguistic varieties (Halliday, 1988; Harris, 1991). While it is widely acknowledged that change in language use is primarily socio-culturally determined pushing towards greater linguistic expressivity, we here highlight the limiting function of communicative factors on diachronic linguistic variation showing that conventionalization and diversification are associated with a reduction of linguistic variability. To be able to observe effects of linguistic variability reduction, we first need a well-defined notion of choice in context. Linguistically, this implies the paradigmatic axis of linguistic organization, i.e., the sets of linguistic options available in a given or similar syntagmatic contexts. Here, we draw on word embeddings, weakly neural distributional language models that have recently been employed to model lexical-semantic change and allow us to approximate the notion of paradigm by neighbourhood in vector space. Second, we need to capture changes in paradigmatic variability, i.e. reduction/expansion of linguistic options in a given context. As a formal index of paradigmatic variability we use entropy, which measures the contribution of linguistic units (e.g., words) in predicting linguistic choice in bits of information. Using entropy provides us with a link to a communicative interpretation, as it is a well-established measure of communicative efficiency with implications for cognitive processing (Linzen and Jaeger, 2016; Venhuizen et al., 2019); also, entropy is negatively correlated with distance in (word embedding) spaces which in turn shows cognitive reflexes in certain language processing tasks (Mitchel et al., 2008; Auguste et al., 2017). In terms of domain we focus on science, looking at the diachronic development of scientific English from the 17th century to modern time. This provides us with a fairly constrained yet dynamic domain of discourse that has witnessed a powerful systematization throughout the centuries and developed specific linguistic conventions geared towards efficient communication. Overall, our study confirms the assumed trends of conventionalization and diversification shown by diachronically decreasing entropy, interspersed with local, temporary entropy highs pointing to phases of linguistic expansion pertaining primarily to introduction of new technical terminology.
Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease

Diabetic kidney disease (DKD) is the most common diabetic complication and is a leading cause of end-stage kidney disease. Increasing evidence shows that DKD is regulated not only by many classical signaling pathways but also by epigenetic mechanisms involving chromatin histone modifications, DNA methylation, and non-coding RNA (ncRNAs). In this review, we focus on our current understanding of the role and mechanisms of ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the pathogenesis of DKD. Of them, the regulatory role of TGF-β/Smad3-dependent miRNAs and lncRNAs in DKD is highlighted. Importantly, miRNAs and lncRNAs as biomarkers and therapeutic targets for DKD are also described, and the perspective of ncRNAs as a novel therapeutic approach for combating diabetic nephropathy is also discussed.
Understanding the Transient Nature of STEM Doctoral Students’ Research Self-Efficacy Across Time: Considering the Role of Gender, Race, and First-Generation College Status

Developing research self-efficacy is an important part of doctoral student preparation. Despite the documented importance of research self-efficacy, little is known about the progression of doctoral students’ research self-efficacy over time in general and for students from minoritized groups. This study examined both within- and between-person stability of research self-efficacy from semester to semester over 4 years, focusing on doctoral students in biological sciences (N = 336). Using random intercept autoregressive analyses, we evaluated differences in stability across gender, racially minoritized student status, and first-generation student status. Results showed similar mean levels of self-efficacy across demographic groups and across time. However, there were notable differences in between-person and within-person stability over time, specifically showing higher between-person and lower within-person stability for racially minoritized and first-generation students. These findings indicate that racially minoritized and first-generation students’ research self-efficacy reports were less consistent from semester to semester. Such results may indicate that non-minoritized and continuing-generation students’ experiences from semester to semester typically reinforce their beliefs about their own abilities related to conducting research, while such is not the case for racially minoritized nor first-generation students. Future research should examine what types of experiences impact self-efficacy development across doctoral study to offer more precise insights about factors that influence these differences in within-person stability.