Miracle-dz/UniFAR-FTUs huggingface dataset:
Embolic Protection with the TriGuard 3 System in Nonagenarian Patients Undergoing Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis

Background: Transcatheter aortic valve replacement (TAVR) improves the survival and life quality of nonagenarian patients with aortic stenosis. Stroke remains one of the most worrisome complications following TAVR. Cerebral embolic protection devices (CEPDs) may reduce neurological complications after TAVR. This study evaluated the safety and efficacy of CEPDs during TAVR in nonagenarian patients. Methods: Between January 2018 and October 2021, 869 patients underwent transfemoral TAVR (TF-TAVR) at our center. Of these, 51 (5.9%) patients were older than ninety years. In 33 consecutive nonagenarian patients, TF-TAVR was implanted without CEPDs using balloon-expandable valves (BEVs) and self-expandable valves (SEVs). Eighteen consecutive nonagenarians underwent TF-TAVR using a CEPD (CP group). Follow up period was in-hospital or 30 days after the procedure, respectively. Results: Minor access site complications occurred in two patients (3.9%) and were not CEPD-associated. Postinterventional delirium occurred in nine patients (17.6%). Periprocedural minor non-disabling stroke and delirium occurred in ten patients (19.6%). Periprocedural major fatal stroke occurred in two patients in the BEV group (3.9%). Two patients in the BEV group died due to postinterventional pneumonia with sepsis. The mortality rate was 7.8%. The results did not differ between the groups. Conclusions: Age alone is no longer a contraindication for TAVR. CEPD using the Triguard 3 system in nonagenarian TAVR patients was feasible and safe and did not increase access site complications.
Design, Fabrication and Analysis of Magnetorheological Soft Gripper

The magnetorheological elastomer is promising material for applications in soft robotics. Its properties like reactive to external magnetic field and softness allow to construct an attractive devices. This work presents a construction of soft gripper assembled with magnetorheological elastomers. The work describes the detailed molding process of magnetorheological elastomers. Further, the electromechanical properties of magnetorheological elastomers are shown using a simple beam. Finally, the soft gripper is constructed and analyzed with the series of experiments.
Reliability Analysis on Main Connection of Power Plants and Substations Taking Fault Clearance and Restoration Into Account

In traditional reliability analysis on main connections of power plants and substations,the fault clearance and restoration are not been taking into account up to now.Based on non-sequential Monte-Carlo simulation,a method to analyze the reliability of main connections of power plants and substations,in which the fault clearance and restoration are organically linked up,is proposed.Firstly,based on topological analysis the cut-set of circuit breakers most adjacent to failed equipment is attained to simulate the operation of fault clearance and during this process both protection failure and circuit breaker miss-operation are taken into account;then closing all non-failed circuit breakers and utilizing the cut-set most adjacent to failed equipment the operation of fault isolation,and the statistics of power demands that cannot met during above-mentioned two process are performed respectively to attain more reasonable fault consequence.Using the proposed method,the result of reliability analysis can be more accurate.Besides,not only the processing of model complexity can be avoided,but also the result of reliability analysis on main connection more conforms to practical situation.The correctness of the proposed method and the effectiveness of the algorithm as well as the necessity of this research are verified by case study and comparison.
Machine learning for zombie hunting: predicting distress from firms’ accounts and missing values

In this contribution, we propose machine learning techniques to predict zombie firms. First, we derive the risk of failure by training and testing our algorithms on disclosed financial information and nonrandom missing values of 304,906 firms active in Italy from 2008 to 2017. We then identify the highest financial distress conditional on predictions that lie above a threshold for which a combination of the false positive rate (false prediction of firm failure) and the false negative rate (false prediction of active firms) is minimized. Therefore, we identify zombies as firms that remain in financial distress, i.e., whose forecasts fall into the risk category above the threshold for at least three consecutive years. To this end, we implement a gradient boosting algorithm (XGBoost) that exploits information about missing values. The inclusion of missing values in our prediction model is crucial because patterns of undisclosed accounts are correlated with firm failure. Finally, we show that our preferred machine learning algorithm outperforms (i) proxy models such as Z-scores and the distance-to-default, (ii) traditional econometric methods, and (iii) other widely used machine learning techniques. We provide evidence that zombies are less productive and smaller on average and that they tend to increase in times of crisis. Finally, we argue that our application can help financial institutions and public authorities design evidence-based policies—e.g., optimal bankruptcy laws and information disclosure policies.
Equivalence of Multi-Formulated Optimal Slip Control for Vehicular Anti-Lock Braking System

Abstract This paper presents the equivalence of time-optimal and optimal distance slip-control approach for purposes of performing antilock braking. A dynamic braking model is developed encorporating a slip state to facilitate slip tracking. Optimal distance braking is performed with control constraints on the dynamic slip based braking model. A similar treatment is applied for time optimal braking on the braking model. The key contribution is the demonstration of the equivalence of optimal distance and time optimal braking of a vehicle. A generalised none zero-terminal condition is utilised in the optimal formulations. Simulation results demonstrate the validity of the approach along with the development of a key optimality condition for the equivalence approach.
Prolonged Labor Characteristics: A Study in Gorontalo

Prolonged labor is one of the common labor complications. The present work is devoted to exploring the characteristics of prolonged labor in Gorontalo. A total of 58 respondents were involved in this descriptive research. Further, this study relied on a retrospective approach. The result showed that the majority of primigravid women experienced prolonged labor (53.4%, n = 31), most of them were in the risky age group (25.9%, n = 15). The percentage of the weak contraction in the prolonged labor cases was 87.9% (n = 51). Regarding the conditions of the newborns, the percentage of abnormal position and malpresentation in the prolonged labor case was 12.1% (n = 7) and 5.2% (n = 3), respectively. The abnormal weight was 2500 - 4000 gram, 8.6% of them were born in the prolonged labor cases (n = 5). Such results confirm the need for the communication, information, education, and motivation approach for women as preventive measures of prolonged labor. This is specifically of important paramount to those who are in the middle of antenatal care visits.
The contribution of the regional child protection commission of Bangka Belitung in dealing with children victims of sexual violence

Over the last two decades, the government has paid much more attention through imposing laws to minimize sexual violence against children. This mostly has been perpetrated by people close to them or extended family members. Accordingly, detrimental effects of such an immoral act case lead to physical problem and psychological disorder in children. Many cases are just the tip of the iceberg whereby disclosure has not been made because perpetrators fully know victims who always face threat in their lives. The interview was conducted with three counselors and key person or supervisor in the Regional Child Protection Commission (KPAD) to raise a concern about victims and to investigate the contribution of the KPAD in dealing with children victims of sexual violence. This study is undertaken as a result of the phenomena of sexual violence occurring in the Bangka Belitung Islands Province. Field research with qualitative descriptive-analysis method was employed in this study, and technique for data analysis applied a model of Miles et al. (2014). The findings showed that the contribution of KPAD in handling with victims of sexual violence against children includes providing assistance and advocacy, recovering trauma, boosting motivation, offering counseling, and giving assistance for legal justice technically and substantively. With the treatment, the KPAD of the Bangka Belitung Islands Province also provide the opportunity to assist the provincial government in facilitating the needs of the community who are able to contribute considerably to deal with the issues of sexual violence against children.
Post-UHP tectonic evolution of the East Kunlun Orogenic Belt, northern Tibetan Plateau: insight from the regional-scale crustal anatexis

ABSTRACT Extensive crustal anatexis is common during the decompressional exhumation of deeply subducted continental crust and the delamination of a collision‐thickened orogenic lithosphere, indicating that determining the timing of partial melting can provide insights into the possible tectonic evolution during orogenic processes. An integrated study of petrology, zirconology and whole-rock geochemical compositions from migmatites and pegmatites in the Nageng, Langmuri and Wulonggou area of the East Kunlun Orogenic Belt, is presented in this study. The protoliths of these migmatites include Tonian sedimentary rocks and ca. 440 Ma arc-related dioritic rock. Together with previous studies, an extensive crustal anatexis event recorded by anatectic zircons occurred after ca. 410 Ma. In addition, hafnium isotope analyses indicate that the anatectic zircons may or may not inherit their Hf isotope compositions from protolith zircons during partial melting, depending on whether or not the garnet Hf contributes to the Hf budget of anatectic melt. Thus, the most reasonable method to trace the source of granite is to compare the Hf isotope composition of anatectic zircon in migmatite and magmatic zircon in contemporaneous granite. By such method, anatectic melt produced by migmatites in this study could account for both penecontemporaneous A- and I-type granites with high magmatic zircon εHf(t) values and S-type granites with low magmatic zircon εHf(t) values. As the extensive crustal anatexis is later than both metamorphic peak and amphibole-facies retrogression of high-pressure and ultrahigh-pressure (HP-UHP) metamorphic rocks, it is reasonable that post-collision orogenic collapse of the collision‐thickened orogenic lithosphere as a result of delamination and asthenospheric upwelling occurred after ca. 410 Ma, which is also supported by contemporaneous granulite-facies metamorphism, molasse deposition, and magmatic events including Xiarihamu mafic-ultramafic intrusions, A-type granites, and mafic dykes formed in the continental rifting setting.
HESI-MS/MS Analysis of Phenolic Compounds from Calendula aegyptiaca Fruits Extracts and Evaluation of Their Antioxidant Activities

Considering medicinal plants as an inexhaustible source of active ingredients that may be easily isolated using simple and inexpensive techniques, phytotherapy is becoming increasingly popular. Various experimental approaches and analytical methods have been used to demonstrate that the genus Calendula (Asteraceae) has a particular richness in active ingredients, especially phenolic compounds, which justifies the growing interest in scientific studies on this genus’ species. From a chemical and biological viewpoint, Calendula aegyptiaca is a little-studied plant. For the first time, high-performance liquid chromatography combined with negative electrospray ionization mass spectrometry (HPLC-HESI-MS) was used to analyze methanolic extracts of Calendula aegyptiaca (C. aegyptiaca) fruits. Thirty-five molecules were identified. Flavonoids (47.87%), phenolic acids (5.18%), and saponins (6.47%) formed the majority of these chemicals. Rutin, caffeic acid hexoside, and Soyasaponin βg’ were the most abundant molecules in the fruit methanolic extract, accounting for 17.49% of total flavonoids, 2.32 % of total phenolic acids, and 0.95% of total saponins, respectively. The antioxidant activity of the fruit extracts of C. aegyptiaca was investigated using FRAP, TAC, and DPPH as well as flavonoids and total phenols content. Because the phenolic components were more extractable using polar solvents, the antioxidant activity of the methanolic extract was found to be higher than that of the dichloromethane and hexane extracts. The IC50 value for DPPH of methanolic extract was found to be 0.041 mg·mL−1. Our findings showed that C. aegyptiaca is an important source of physiologically active compounds.
Swine Enteric Coronavirus: Diverse Pathogen–Host Interactions

Swine enteric coronavirus (SeCoV) causes acute gastroenteritis and high mortality in newborn piglets. Since the last century, porcine transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) have swept farms all over the world and caused substantial economic losses. In recent years, porcine delta coronavirus (PDCoV) and swine acute diarrhea syndrome coronavirus (SADS-CoV) have been emerging SeCoVs. Some of them even spread across species, which made the epidemic situation of SeCoV more complex and changeable. Recent studies have begun to reveal the complex SeCoV–host interaction mechanism in detail. This review summarizes the current advances in autophagy, apoptosis, and innate immunity induced by SeCoV infection. These complex interactions may be directly involved in viral replication or the alteration of some signal pathways.
Treating Gingival Recessions Using Coronally Advanced Flap or Tunnel Techniques with Autografts or Polymeric Substitutes: A Systematic Review and Meta-Analysis

Gingival recessions are a prevalent oral mucosa alteration. To solve this pathology, palatal mucosa or polymeric soft tissue substitutes are used when performing coronal advanced flap (CAF) or tunnel (TUN) surgical techniques. To evaluate which is the most successful approach, a literature review and meta-analysis were conducted. For the electronic search the National Library of Medicine, the Cochrane Oral Health Group Trials Register, EMBASE and WOS were used. Pooled data for the percentage of root coverage was collected and weighted means were calculated. Heterogeneity was determined using the Higgins (I2) statistic and a random-effects model was applied. Thirteen studies were included in the systematic review (12 randomized and 1 controlled clinical trials) in which both techniques (394 patients) were compared with a follow-up of 4 to 12 months. Galbraith and Baujat plots were used to control for the presence of potential outliers. After performing the meta-analysis (11 studies), the mean root coverage was similar when using the TUN or CAF techniques (p = 0.49). The only differences between the two were found for single recessions, where CAF offered a higher percentage of root coverage (mean difference = 4.98%; p = 0.006). There were no differences when applying an autograft or a polymeric substitute with either of the two tested surgical techniques (p = 0.445).
Mechanical Response and Failure Mechanisms of Natural Bamboo Fiber Reinforced Poly-Benzoxazine Composite Subjected to Split-Hopkinson Tensile Bar Loading

In this study, chopped natural bamboo fibers were successfully added in the benzoxazine matrix by the hot-pressing method to fabricate environmentally friendly bio-composite. The mechanical behaviors and failure mechanisms of neat benzoxazine matrix and its bamboo fiber composite under different tensile strain rates (quasi-static, 35/s and 110/s) were comparatively investigated using SHTB device (split-Hopkinson tensile bar), high-speed camera, DIC method (digital image correlation), and SEM observation (scanning electron microscopy). The results showed the composite exhibited 30.02% and 25.21% higher strength than that of neat benzoxazine under strain rates of 35/s and 110/s, respectively. However, under quasi-static tensile loading, the tensile strength of the composite was not higher than that of neat benzoxazine. The SEM and high-speed camera images showed the bamboo fibers displayed different reinforcing mechanisms under different strain rates. The chopped bamboo fibers could strengthen the composite effectively under dynamic tensile loadings. However, under quasi-static loading, the tensile strength of the composite was largely determined by the potential defects (such as small bubbles, pores, and fiber agglomerations) in the composite.
Tropheryma whipplei, Helicobacter pylori, and Intestinal Protozoal Co-Infections in Italian and Immigrant Populations: A Cross-Sectional Study

Tropheryma whipplei (TW), Helicobacter pylori (HP), and intestinal protozoa (IP) are widespread pathogens with similar routes of transmission and epidemiological risk factors. Epidemiological data on co-infection between TW, HP, and IP are scarce. We aim to more deeply investigate the co-infection rate for these pathogens, evaluating the risk factors and symptoms. Methods: This is a cross-sectional study conducted at the IRCCS Sacro Cuore Don Calabria Hospital in Northern Italy, a referral center for tropical and Whipple’s disease (WD). Stored stool samples from 143 subjects previously tested for TW DNA by real-time PCR were explored for HP and IP DNA detection. The virulence factor cagA was investigated in HP-positive patients. Results: A history of migration was reported significantly more in TW-positive than in negative subjects (34.1% vs. 9.1%, p = 0.001) and in HP-infected than in those non-infected (59.1% vs. 9.1%, p < 0.001). The HP infection rate differed significantly between TW-infected and uninfected groups (31.8% vs. 8.1%, p = 0.001), while no difference was observed for IP infection. Significantly higher TW intestinal colonization was found in HP-infected patients than in non-infected (63.6% vs. 24.8%, p < 0.001). In addition, the proportion of Blastocysts positive finding was also significantly higher in HP-infected than in non-infected (40.9% vs. 17.4%, p = 0.018). Conclusions: The present study is the first to report a high TW and HP co-infection rate. To reduce the risk of morbidity from a chronic infection of either pathogen, clinicians may consider TW-HP molecular screening on the same stool sample for patients with suspected HP disease or WD, particularly in case of travel history.
Radical social innovations and the spatialities of grassroots activism: navigating pathways for tackling inequality and reinventing the commons

In this article, by drawing on empirical evidence from twelve case studies from nine countries from across the Global South and North, we ask how radical grassroots social innovations that are part of social movements and struggles can offer pathways for tackling socio-spatial and socio-environmental inequality and for reinventing the commons. We define radical grassroots social innovations as a set of practices initiated by formal or informal community-led initiatives or/and social movements which aim to generate novel, democratic, socially, spatially and environmentally just solutions to address social needs that are otherwise ignored or marginalised. To address our research questions, we draw on the work of Cindi Katz to explore how grassroots innovations relate to practices of resilience, reworking and resistance. We identify possibilities and limitations as well as patterns of spatial practices and pathways of re-scaling and radical praxis, uncovering broadly-shared resemblances across different places. Through this analysis we aim to make a twofold contribution to political ecology and human geography scholarship on grassroots radical activism, social innovation and the spatialities of resistance. First, to reveal the connections between social-environmental struggles, emerging grassroots innovations and broader structural factors that cause, enable or limit them. Second, to explore how grassroots radical innovations stemming from place-based community struggles can relate to resistance practices that would not only successfully oppose inequality and the withering of the commons in the short-term, but would also open long-term pathways to alternative modes of social organization, and a new commons, based on social needs and social rights that are currently unaddressed.
Observations of Microstructure-Oriented Crack Growth in a Cast Mg-Al-Ba-Ca Alloy under Tension, Compression and Fatigue

DieMag633, a cast Mg-Al-Ba-Ca alloy, was the focus of this study. Brittle interdendritic phases strongly influenced the crack initiation and propagation under quasi-static and fatigue loading. Especially under tensile loading, the material showed a low resistance to failure. Selected fatigue loading sequences were applied to investigate their influence on crack propagation. DieMag633 in this study contained shrinkage cavities and pores of significant size and irregular distribution. Even though pores played a role in initiating the crack, it was mainly influenced by the Ba- and Ca-rich phases, being and staying much harder under deformation than the Mg-matrix. Apart from the fatigue crack propagation region under fatigue loading, there was no transgranular cracking found within the dendritic α-Mg grains. Only under compression did the dendritic α-Mg grains bridge the crack from one brittle phase to another. Transgranular cracking within the compact Ba-rich phase was very pronounced, starting with many microcracks within this phase and then connecting to the macrocrack. The lamellar Ca-rich phase showed also mainly transgranular cracking, but being small lamellae, intergranular cracking was additionally found. The hardness increase under deformation depended on the loading condition; a compression load strain-hardened the material the most. µCT analysis was applied to characterize the amount and location of the shrinkage cavities and pores in the individual gauge length.
Mycobacterium tuberculosis and Pulmonary Rehabilitation: From Novel Pharmacotherapeutic Approaches to Management of Post-Tuberculosis Sequelae

Tuberculosis (TB) is still a worldwide public health burden, as more than 1.3 million deaths are expected to be reported in 2021. Even though almost 20 million patients have completed specific anti-TB treatment and survived in 2020, little information is known regarding their pulmonary sequelae, quality of life, and their need to follow rehabilitation services as researchers shifted towards proper diagnosis and treatment rather than analyzing post-disease development. Understanding the underlying immunologic and pathogenic mechanisms during mycobacterial infection, which have been incompletely elucidated until now, and the development of novel anti-TB agents could lead to the proper application of rehabilitation care, as TB sequelae result from interaction between the host and Mycobacterium tuberculosis. This review addresses the importance of host immune responses in TB and novel potential anti-TB drugs’ mechanisms, as well as the assessment of risk factors for post-TB disease and usefulness of guidance and optimization of pulmonary rehabilitation. The use of rehabilitation programs for patients who successfully completed anti-tuberculotic treatment represents a potent multifaceted measure in preventing the increase of mortality rates, as researchers conclude that a patient with a TB diagnosis, even when properly completing pharmacotherapy, is threatened by a potential life loss of 4 years, in comparison to healthy individuals. Dissemination of pulmonary rehabilitation services and constant actualization of protocols could strengthen management of post-TB disease among under-resourced individuals.