Miracle-dz/UniFAR-FTUs huggingface dataset:
ANTIOXIDANT EFFECT OF POLYHERBAL FORMULATION IN ISOPRENALINE HYDROCHLORIDE INDUCED MYOCARDIAL INFARCTION IN RATS

Objective: Myocardial infarction (MI) continues to be a major public health problem in the world. The prepared polyherbal formulation (PHF) exhibit cardioprotective effects by several mechanisms. The objective of the research was to evaluate the antioxidant effect of a polyherbal formulation in isoprenaline hydrochloride (ISO) induced myocardial infarction in rats. Methods: Oxidative stress and myocardial infarction was induced by administration of isoprenaline hydrochloride (25 mg/kg) for 2 d. The degree of protection was determined by measuring the levels of lipid peroxidation (LPO), enzymatic antioxidants (superoxide dismutase-SOD, Catalase, Glutathione peroxidase) and non-enzymatic antioxidants (Vitamin C, E and reduced glutathione-GSH). Results: Two different doses (250 mg and 500 mg/kg body wt) of the formulation was used to prove the cardioprotective effect. Pretreatment with polyherbal formulation significantly (P<0.05) lowered LPO and elevated the enzymatic and non-enzymatic antioxidants in heart homogenate. Conclusion: The polyherbal formulation exhibited cardioprotective activity, which could be attributed to its antioxidant activity.
Relationship Between Learners’ Attitudes And Achievement In English In Secondary Schools In Emuhaya Sub County, Kenya

Poor performance in English in Secondary Schools in Kenya has been a long time problem. This acts as a hindrance for learners to join institutions of higher learning since most courses offered in these institutions require one to have passed in the subject. For the last five years, Emuhaya Sub County has been posting low mean scores in English. Between 2013 and 2017, the sub county posted an average mean score of 4.26 compared to its neighbor Hamisi with an average mean of 4.51. Studies have revealed that attitudes towards the English language can be caused by several factors but have not shown the relationship between these attitudes and students achievement in English. This study therefore intended to determine the relationship between learners’ attitude and achievement in English in secondary schools in Emuhaya Sub County, Kenya. The objectives of this study were: to determine the relationship between students’ attitudes towards curriculum objectives and achievement in English; to determine the relationship between students’ attitudes towards learning experiences and achievement in English; to determine the relationship between students’ attitudes towards teaching methods and achievement in English; to determine the relationship between students’ attitudes towards evaluation and achievement in English. This study adopted correlation and survey designs. Simple random sampling was used to select the students and teachers who participated in the study. The sample consisted of 341 form four students and 20 teachers. Data was collected through teachers’ and students’ questionnaires, students’ interview schedule and a students’ score sheet. Quantitative data was analyzed through frequencies, means and percentages. Pearson’s correlation was used to analyze relationships between variables. Qualitative data was analyzed for content in emergent themes. The study found out that the relationship between students’ attitudes towards the English language curriculum and their achievement in terms of learning activities and methods was generally significant with Pearson’s r of . 67 and . 64 respectively; meaning that when teachers employ more learner friendly methods and experiences in their teaching of English, learners will improve in their attitude hence better achievement. The study recommends that teachers use more of learner centered approaches in teaching. The findings of this study are significant in helping teachers change their approaches to teaching English and help curriculum developers in in-servicing teachers of English on the best methods and experiences to be employed in teaching English. In the long run, an improvement in learner achievement is to be noted.
Salinomycin inhibits epigenetic modulator EZH2 to enhance Death Receptors in Colon Cancer Stem Cells

Drug resistance is one of the trademark features of Cancer Stem Cells (CSCs). We and others have recently shown that paucity of functional death receptors (DR4/5) on the cell surface of tumor cells is one of the major reasons for drug resistance, but their involvement in the context of in CSCs is poorly understood. By harnessing CSC specific cytotoxic function of salinomycin, we discovered a critical role of epigenetic modulator EZH2 in regulating the expression of DRs in colon CSCs. Our unbiased proteome profiler array approach followed by ChIP analysis of salinomycin treated cells indicated that the expression of DRs, especially DR4 is epigenetically repressed in colon CSCs. Concurrently, EZH2 knockdown demonstrated increased expression of DR4/DR5, significant reduction of CSC phenotype such as spheroid formation in-vitro and tumorigenic potential in-vivo in colon cancer. TCGA data analysis of human colon cancer clinical samples shows strong inverse correlation between EZH2 and DR4. Taken together, this study provides an insight about epigenetic regulation of DR4 in colon CSCs and advocates that drug resistant colon cancer can be therapeutically targeted by combining TRAIL and small molecule EZH2 inhibitors.
Sex composition of children and fertility behaviour in rural Maharashtra.

This book chapter presents an analysis of son preference and fertility and contraceptive use in four different districts of Maharashtra state India. Data were obtained from a baseline survey conducted in January 1991 in rural areas among 592 currently married women in Bhandara 1100 in Chandrapur 576 in Dhule and 517 in Nagpur. The study area had well developed family planning programs. Findings indicate that sex of the first child did significantly affect fertility among women with only one child: women with sons had significantly lower fertility. Fertility was 2.91 among women with sons and 3.21 among women with daughters. Women whose first two children were sons had an average of 4.19 children compared with 4.46 children among women who had two daughters. Over 90% of contraceptors were sterilized. Contraceptive use was the lowest among women with no sons. The odds of contraceptive use among women with two sons was almost double the odds of use among women with two daughters. Maternal educational status was related to contraceptive use but not fertility. The odds of contraceptive use was lower among illiterates. Among the sample of women aged 15-44 years son preference was evident in the desire for more children. Most desired at least two sons. Analysis suggested by Arnold (1987) reveals that the percentage of women not desiring more children would have increased by 10 points if there was no preference for sons. The desire for more children was influenced by the sex of the first child or the first two children and was lowest among women whose first two children were sons. None of the socioeconomic variables had an influence on desire for more children.
Contributions of climate change, land use change and CO2 to changes in the gross primary productivity of the Tibetan Plateau

ABSTRACT The ecosystems on the Tibetan Plateau (TP) are highly vulnerable to climate change, rising CO2 concentration, and land-use and land-cover change (LULCC), but their contributions to changes in the gross primary productivity (GPP) of the TP are not clearly understood. In this study, the role of these three factors on the interannual variations (IAVs) and trends of the TP’s GPP were investigated using 12 terrestrial biosphere models. The ensemble simulations showed that climate change can explain most of the changes in the GPP, while the direct effect of LULCC and rising CO2 (mainly fertilization effect) contributed 10% and −14% to the mean GPP values, 37% and −20% to the IAV, and 52% and −24% to the GPP’s trend, respectively. The LULCC showed higher contributions to the significant positive trend in the annual GPP of the TP. However, the results from different model simulations showed that considerable uncertainties were associated with the effects of LULCC on the GPP of the TP. Key figure (only for online)
153Implementing Digital Life Story Work for People with Dementia: The Relevance of Context to User Experience

Background: Digital Life Story Work is fast becoming a major trend in reminiscence work for people with dementia. Now, the life storybook (LSB) can be created digitally, incorporating a range of multimedia stimuli to build a multisensory experience. Currently, it is used in many different settings, in a variety of ways. This research aims to explore user experiences of three different implementations of digital LSW. Methods: 16 participants including people with dementia, family caregivers and care home staff were interviewed regarding their experience of learning to use a digital LSB across three distinct contexts: a community group; one-to-one sessions with a volunteer; and a care home. Interviews were semi structured. Results were analysed separately for each group using a thematic analysis before identifying common themes. Results: Making connections was the overarching theme. People with dementia felt that using the LSB helped them reconnect with their past. In the group context, family caregivers felt the social setting was the most valuable part, both for themselves and the person with dementia. In the one-to-one context, family caregivers valued the facilitator’s presence and enjoyed bonding over memories. For care staff, the LSB facilitated meaningful interactions and communication with residents and families. They also used the app for some unanticipated but positive purposes. All participants enjoyed the intervention, found it useful, and valued the digital LSB’s capacity to host multimedia materials. Limited IT skills was the most frequently cited barrier. Conclusions: This study provides evidence for the feasibility and positive impact of a digital LSB across different contexts.
Effect of Hydroalcoholic Extract of Teucrium polium on the Process of Wound Healing in Diabetic Rats

Wound healing is physiological process, passing through three main overlapping phases, including inflammatory, proliferative, and remodeling phase to repair the damaged tissue. Some vital process in wound healing, including inflammatory cell infiltration, angiogenesis and collagen tissue formation, seems to be disrupted in diabetes, which is a metabolic disorder. The aims of this study were to investigate the effect of different concentrations of hydroalcoholic extract of Teucrium polium, which is a medicinal plant, on the process of wound healing in diabetic rats. Diabetes were induced in twenty adult Albino-rats using a single intraperitoneal injection of streptozocin. Five wounds were created on the back of each rat, and treated as control (untreated), vasaline-treated, and 5%, 10% or 15% Teucrium polium extract-treated. The results showed that Teucrium polium extract stimulated wound healing by enhancing the rate of wound retraction, angiogenesis, fibroblast proliferation, collagen deposition, and maturation. Although there was a reduction in the level of granulation tissue thickness deposition within the wound. The rate of the epithelial regeneration was improved, and the thickness of the regenerated epithelium was reduced. Overall, there was a promising impact of the extract on the process of wound healing through improving different phases of the process.
Distribution and prognostic validity of the new GOLD grading classification.

Abstract ABSTRACT BACKGROUND: The new GOLD update includes airflow limitation, history of COPD exacerbations and symptoms to classify and grade COPD severity. We aimed to determine their distribution in eleven, well defined COPD cohorts, and their prognostic validity up to 10 years to predict time to death. METHODS: Spirometry in all eleven cohors was post-bronchodilator. Survival analysis and C-statistics were used to compare the two GOLD systems by varying time points. RESULTS: Of 3,633 patients, 1,064 (33.6%) were in new GOLD patient group A (low risk, less symptoms); 515 (16.3%) were B (low risk, more symptoms); 561 (17.7%) were C (high risk, less symptoms); and 1,023 (32.3%) were D (high risk, more symptoms). There was great heterogeneity of this distribution within the cohorts (Chi2 p value alt; 0.01). No differences were seen in the C statistics of old versus new GOLD grading to predict mortality at one year (0.635 vs. 0.639, p=0.53, at three years (0.637 vs. 0.645, p=0.21) or at 10 years (0.639 vs. 0.642, p=0.76). CONCLUSIONS: The new GOLD grading produces an uneven split of the COPD population, one third each in A and D patient groups, and its prognostic validity to predict time to death is no different than the old GOLD staging based in spirometry only.1Fundacion Caubet-Cimera Illes Balears, Bunyola, Spain; 2Hospital Universitario Valme, Sevilla; 3Internal Medicine, Hospital Universitari Mutua de Terrassa, Universitat de Barcelona, Barcelona; 4Hospital Nuestra Senora de la Candelaria, Tenerife; 5Hospital Galdakao-Usansolo, Galdakao, Bizkaia 6Unidad de Neumologia, Servicio de Medicina Interna, Hospital General de Requena, Valencia; 7Clinica Universidad de Navarra, Pamplona; 8CAIBER, Oficina de Investigacion Biosanitaria de Asturias, Oviedo; 9Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain; 10Harvard University, Brigham and Women's Hospital, Pulmonary and Critical Care Medicine, Boston, MA, USA; 11Hospital Universitario Miguel Servet, Zaragoza, SpainAuthor for correspondence: Dr. Joan B Soriano Director, Program of Epidemiology a Clinical Research CIMERA. Recinte Hospital Joan March, Carretera Soller Km 12. 07110 - Bunyola, Illes Balears; Spain Email: jbsoriano@caubet-cimera.esFINANCIAL DISCLOSURE INFORMATION: No funding was required/available for COCOMICS.
Total extraperitoneal approach in inguinal hernia repair: an update

Inguinal hernia can be repaired through numerous approaches either by conventional open or endo-laparoscopic technique. Few factors are contributing to the increasing popularity of endo-laparoscopic approach: firstly the several studies that showed the benefits and advantages of the technique then, the widest application of laparoscopic techniques in all fields of surgery including advanced procedures, making the, once defined “difficult to learn”, endoscopic hernia repair easier and lastly, the improvement of imaging technology from high definition to the 3D. Total extraperitoneal (TEP) inguinal hernia repair requires a proper training and a good standard technique in order to be mastered with low recurrence and complications.
Variational Pathway Reasoning for EEG Emotion Recognition

Research on human emotion cognition revealed that connections and pathways exist between spatially-adjacent and functional-related areas during emotion expression (Adolphs 2002a; Bullmore and Sporns 2009). Deeply inspired by this mechanism, we propose a heuristic Variational Pathway Reasoning (VPR) method to deal with EEG-based emotion recognition. We introduce random walk to generate a large number of candidate pathways along electrodes. To encode each pathway, the dynamic sequence model is further used to learn between-electrode dependencies. The encoded pathways around each electrode are aggregated to produce a pseudo maximum-energy pathway, which consists of the most important pair-wise connections. To find those most salient connections, we propose a sparse variational scaling (SVS) module to learn scaling factors of pseudo pathways by using the Bayesian probabilistic process and sparsity constraint, where the former endows good generalization ability while the latter favors adaptive pathway selection. Finally, the salient pathways from those candidates are jointly decided by the pseudo pathways and scaling factors. Extensive experiments on EEG emotion recognition demonstrate that the proposed VPR is superior to those state-of-the-art methods, and could find some interesting pathways w.r. t. different emotions.
On the Possible Concepts of the Transition to a Low-carbon Economy

Aiming for a reduction of the dependence on polluting energy sources, countries set targets in terms of energy generation from renewables. This translates into a regime shift in the production of energy, with costs for the economy. Subsidizing clean production represents one possible policy measure to cover such costs. We develop a general equilibrium model to analyze the subsidy required to achieve a target of clean energy production, while accounting for knowledge spillovers, substitutability between clean and dirty energy and labor mobility. Our findings show that, in order to reduce the costs of the regime shift to a low-carbon economy, policies should improve the absorption capacity of the clean energy sector, ease the substitutability between clean and dirty energy and promote labor mobility. Financial support from Innosuisse (Suisse Innovation Agency) is greatly acknowledged.
Understanding the experience and multidimensional needs of Ugandan patients with advanced heart failure

5 LAY SUMMARY . 7 PROLOGUE AND OVERVIEW OF THE THESIS . 9 OPERATIONAL DEFINITIONS AND TERMINOLOGY USED: . 12 ACRONYMS . 16 TABLE OF CONTENTS . 17 LIST OF FIGURES . 24 LIST OF TABLES . 24 CHAPTER ONE . 25 1.0 Introduction . 25 1.1 The significance of non-communicable diseases globally and particularly in SubSaharan Africa . 25 1.2 The significance of cardiovascular diseases as a subgroup of non-communicable diseases . 26 1.3 Heart Failure in Africa and Uganda . 26 1.4 The study context . 29 1.5 Rationale for the study . 32 1.6 The experience of living and dying with a chronic disease . 34 1.6. 1 Understanding the chronic illness experience . 34 1.6. 2 The concept of the patient’s illness experience . 35 1.6. 3 The chronic illness experience existing theories . 38 1.6. 4 The experiences of dying of chronic illness . 43 1.6. 5 Management frameworks for chronic illness . 46 CHAPTER TWO . 48 2.0 Introduction . 48 2.1 Review of the literature exploring the experience of living and dying of advanced heart failure and the associated multidimensional needs . 50 2.1.1 Disease trajectory of heart failure . 50 2.1.2 Physical needs and issues in the heart failure experience . 52 2.1.3 Social needs and experiences . 56 2.1.4 Psychological needs and experiences . 59 2.1.5 Spiritual experience and needs . 62 2.1.6 Information needs . 64
Pneumothorax, pneumomediastinum, and subcutaneous emphysema: A rare case of complication after pacemaker implantation

Pneumothorax is a relatively common early complication after pacemaker implantation due to subclavian vein puncture, while pneumothorax associated pneumomediastinum and subcutaneous emphysema are rather unusual. Herein, we reported a case of bilateral pneumothorax associated with pneumomediastinum and widespread bilateral subcutaneous emphysema after pacemaker implantation due to percutaneous subclavian vein approach after multiple attempts and was successfully relieved by continuous low-volume oxygen inhalation, subcutaneous needles, and incision drainage.
The Excellence of Pharmacy Service: Past, Present and Future

Pharmacy education continues to evolve to better prepare pharmacists for their roles and responsibilities in an increasingly complex health care environment with advanced patient health needs. Another important factor is the pharmacists themselves. Over the past 50 years, the role of pharmacists has evolved along with the health care needs of our population. In addition to dispensing medications and ensuring patient safety, today’s pharmacists are taking a larger role as medical counselors, educators and advocates. They are integral part of the health care team, and are among the most trusted and accessible health care professionals. This accessibility allows them to perform more patient care activities, including counseling, medication management, and preventive care screenings. Beyond the care provided to individual patients, pharmacists have expanded their reach to influence the public health of communities. A pharmacist is uniquely positioned to provide disease state management through appropriate medication therapy management that has been demonstrated to improve patient outcomes and decrease overall health care costs. This role is more important than ever as the environment is demanding new practice and payment models that are required to further optimize care and outcomes while addressing the unsustainable increases in health care costs. All people who take medications are at risk of actual or potential drug therapy problems. These problems are a significant source of morbidity and mortality when left undetected and unresolved and drive huge costs across the health system. As drug therapy experts, pharmacists provide drug therapy management services built around a partnership between the pharmacist, the patient (or his or her caregiver), physicians and other members of a patient’s health care team.
Critical success factors on project and process management in competitive strategy implementation

Goal: Raise in the literature of project and process management the critical success factors needed to implement a competitive strategy aiming to rank them and to recommend guidelines for a successful competitive strategy implementation. Design / Methodology / Approach: In order to reach the desired objectives, a research was carried out in the literature, enabling the creation of the questionnaire that was applied as a data collection instrument and the use of relative frequency analysis and measurement of the central tendency, mode, as the statistical treatments. Results: All the 42 requirements raised in the literature were considered as critical success factors for competitive strategy implementation and the analysis of the professionals’ answers made it possible to include a further 12 critical success factors. Limitations of the investigation: The size of the sample, which was conditioned to the number of respondents of the questionnaire distributed by electronic means. And because the size of the population is unknown, it is not possible to realize generalizations. Practical implications: A recommendation for companies was prepared through four priority actions in the competitive strategy implementation. The research concluded that, beyond the pillar’s strategy, processes, and projects, the people, whether clients or employees, need to be included as one of the bases for competitive advantage. Originality / Value: The scheme ranking the requirements’ relevance for competitive strategy implementation is a way to support companies to promote actions to adapt the corporate environment, so that all of productive links are aligned with the strategic objectives. Suzy Almeida Ferreira suzyalfer@gmail.com Fluminense Federal University – UFF, Niterói, Rio de Janeiro, Brazil. Julio Vieira Neto julion@id.uff. br Fluminense Federal University – UFF, Niterói, Rio de Janeiro, Brazil. Haydee Maria Correia da Silveira Batista haydeemcsb@gmail.com Fluminense Federal University – UFF, Niterói, Rio de Janeiro, Brazil. Brazilian Journal of Operations & Production Management Volume 16, Número 4, 2019, pp. 605-616 DOI: 10.14488/BJOPM.2019. v16.n4. a6 606