Miracle-dz/UniFAR-FTUs huggingface dataset:
ULTRAFAST ELECTRON DYNAMICS IN FEMTOSECOND OPTICAL BREAKDOWN OF DIELECTRICS

We measured the optical breakdown threshold (OBT) in dielectrics with different band gaps for single and double 25-fs 800-nm transform-limited laser pulses. Our pump-probe double pulse measurements indicate that the plasma energy in dielectrics experiences ultrafast decay which lasts only ,100 fs and does not follow an exponential decay curve. Therefore, a decay term must be included in the electron density rate equation. Our double pulse measurements also demonstrate that the OBT is temperature dependent. The OBT in dielectrics was determined using a novel technique, which eliminates the ambiguity in its definition and also allows real-time data acquisition. [S0031-9007(99)08660-3]
Evolution of Indian Influenza A (H1N1) Hemagglutinin Strains: A Comparative Analysis of the Pandemic Californian HA Strain

The need for a vaccine/inhibitor design has become inevitable concerning the emerging epidemic and pandemic viral infections, and the recent outbreak of the influenza A (H1N1) virus is one such example. From 2009 to 2018, India faced severe fatalities due to the outbreak of the influenza A (H1N1) virus. In this study, the potential features of reported Indian H1N1 strains are analyzed in comparison with their evolutionarily closest pandemic strain, A/California/04/2009. The focus is laid on one of its surface proteins, hemagglutinin (HA), which imparts a significant role in attacking the host cell surface and its entry. The extensive analysis performed, in comparison with the A/California/04/2009 strain, revealed significant point mutations in all Indian strains reported from 2009 to 2018. Due to these mutations, all Indian strains disclosed altered features at the sequence and structural levels, which are further presumed to be associated with their functional diversity as well. The mutations observed with the 2018 HA sequence such as S91R, S181T, S200P, I312V, K319T, I419M, and E523D might improve the fitness of the virus in a new host and environment. The higher fitness and decreased sequence similarity of mutated strains may compromise therapeutic efficacy. In particular, the mutations observed commonly, such as serine-to-threonine, alanine-to-threonine, and lysine-to-glutamine at various regions, alter the physico-chemical features of receptor-binding domains, N-glycosylation, and epitope-binding sites when compared with the reference strain. Such mutations render diversity among all Indian strains, and the structural and functional characterization of these strains becomes inevitable. In this study, we observed that mutational drift results in the alteration of the receptor-binding domain, the generation of new variant N-glycosylation along with novel epitope-binding sites, and modifications at the structural level. Eventually, the pressing need to develop potentially distinct next-generation therapeutic inhibitors against the HA strains of the Indian influenza A (H1N1) virus is also highlighted here.
Prefrontal Cortex Hemodynamics and Functional Connectivity Changes during Performance Working Memory Tasks in Older Adults with Sleep Disorders

Objective: Older adults with sleep disorders (SDs) show impaired working memory abilities, and working memory processes are closely related to the prefrontal cortex (PFC). However, the neural mechanism of working memory impairment in older adults with SD remains unclear. This study aimed to investigate changes in PFC function among older adults with SD when carrying out the N-back task by functional near-infrared spectroscopy (fNIRS). Method: A total of 37 older adults with SDs were enrolled in this study and matched with 37 healthy older adults by gender, age, and years of education. Changes in PFC function were observed by fNIRS when carrying out the N-back task. Results: The accuracy on the 0-back and 2-back tasks in the SD group was significantly lower than that in the healthy controls (HC) group. The oxygenated hemoglobin (oxy-Hb) concentration of channel 8 which located in the dorsolateral prefrontal cortex (DLPFC) was significantly reduced in the SD group during the 2-back task, and the channel-to-channel connectivity between the PFC subregions was significantly decreased. Conclusions: These results suggest that patients with sleep disorders have a weak performance of working memory; indeed, the activation and functional connectivity in the prefrontal subregions were reduced in this study. This may provide new evidence for working memory impairment and brain function changes in elderly SDs.
Current collection by a cylindrical probe in a partly ionized, collisional plasma

A numerical calculation of ion and electron current collection by a cylindrical Langmuir probe in a partly ionized plasma has been done. The effect of electron and ion collisions with neutrals on the current collected by the probe has been investigated. The validity of the collisionless theory of Laframboise [J. G. Laframboise, University of Toronto, Institute for Aerospace Studies, UTIAS Report No. 100 (1966)] has been studied. The iterative scheme of Laframboise has been combined with Monte Carlo solution of the Boltzmann equation to provide self-consistent steady-state electron and ion density and electric potential distributions as functions of radius. Our model includes elastic ion-neutral and electron-neutral collisions, ionization of neutrals by electron impact, energy loss of electrons due to excitation and ionization of neutrals, and charge-exchange collisions. Our model has been demonstrated by calculating the current collection by a probe in a nitrogen plasma, but it can be applied in other cas.
Coordinated inauthentic behavior: An innovative manipulation tactic to amplify COVID-19 anti-vaccine communication outreach via social media

Coordinated inauthentic behavior (CIB) is a manipulative communication tactic that uses a mix of authentic, fake, and duplicated social media accounts to operate as an adversarial network (AN) across multiple social media platforms. The article aims to clarify how CIB's emerging communication tactic “secretly” exploits technology to massively harass, harm, or mislead the online debate around crucial issues for society, like the COVID-19 vaccination. CIB's manipulative operations could be one of the greatest threats to freedom of expression and democracy in our society. CIB campaigns mislead others by acting with pre-arranged exceptional similarity and “secret” operations. Previous theoretical frameworks failed to evaluate the role of CIB on vaccination attitudes and behavior. In light of recent international and interdisciplinary CIB research, this study critically analyzes the case of a COVID-19 anti-vaccine adversarial network removed from Meta at the end of 2021 for brigading. A violent and harmful attempt to tactically manipulate the COVID-19 vaccine debate in Italy, France, and Germany. The following focal issues are discussed: (1) CIB manipulative operations, (2) their extensions, and (3) challenges in CIB's identification. The article shows that CIB acts in three domains: (i) structuring inauthentic online communities, (ii) exploiting social media technology, and (iii) deceiving algorithms to extend communication outreach to unaware social media users, a matter of concern for the general audience of CIB-illiterates. Upcoming threats, open issues, and future research directions are discussed.
Probing long bones with ultrasonic body waves

This study uses seismological principles and techniques including waveform simulations and travel time calculations to reveal the nature of ultrasoundwave propagation in long bones at small offsets (source-to-receiver distances) and times. Our experiments confirm the existence of reflected and converted body waves originating from wave interaction at the internal interfaces of a bone structure. We demonstrate that the bone ultrasound responses can be successfully simulated and properly interpreted based on a simple, horizontally layered approximation.
NSCLC in the Era of Targeted and Immunotherapy: What Every Pulmonologist Must Know

The treatment of non-small cell lung cancer has dramatically changed over the last decade through the use of targeted therapies and immunotherapies. Implementation of these treatment regimens relies on detailed knowledge regarding each tumor’s specific genomic profile, underscoring the necessity of obtaining superior diagnostic tissue specimens. While these treatment approaches are commonly utilized in the metastatic setting, approval among earlier-stage disease will continue to rise, highlighting the importance of early and comprehensive biomarker testing at the time of diagnosis for all patients. Pulmonologists play an integral role in the diagnosis and staging of non-small cell lung cancer via sophisticated tissue sampling techniques. This multifaceted review will highlight current indications for the use of targeted therapies and immunotherapies in non-small cell lung cancer and will outline the quality of various diagnostic approaches and subsequent success of tissue biomarker testing. Pulmonologist-specific methods, including endobronchial ultrasound and guided bronchoscopy, will be examined as well as other modalities such as CT-guided transthoracic biopsy and more.
Water-Soluble Saccharina latissima Polysaccharides and Relation of Their Structural Characteristics with In Vitro Immunostimulatory and Hypocholesterolemic Activities

Brown macroalgae are an important source of polysaccharides, mainly fucose-containing sulphated polysaccharides (FCSPs), associated with several biological activities. However, the structural diversity and structure–function relationships for their bioactivities are still undisclosed. Thus, the aim of this work was to characterize the chemical structure of water-soluble Saccharina latissima polysaccharides and evaluate their immunostimulatory and hypocholesterolemic activities, helping to pinpoint a structure–activity relationship. Alginate, laminarans (F1, neutral glucose-rich polysaccharides), and two fractions (F2 and F3) of FCSPs (negatively charged) were studied. Whereas F2 is rich in uronic acids (45 mol%) and fucose (29 mol%), F3 is rich in fucose (59 mol%) and galactose (21 mol%). These two fractions of FCSPs showed immunostimulatory activity on B lymphocytes, which could be associated with the presence of sulphate groups. Only F2 exhibited a significant effect in reductions in in vitro cholesterol’s bioaccessibility attributed to the sequestration of bile salts. Therefore, S. latissima FCSPs were shown to have potential as immunostimulatory and hypocholesterolemic functional ingredients, where their content in uronic acids and sulphation seem to be relevant for the bioactive and healthy properties.
Cannabinoid WIN55,212-2 reprograms monocytes and macrophages to inhibit LPS-induced inflammation

Introduction Chronic or uncontrolled activation of myeloid cells including monocytes, macrophages and dendritic cells (DCs) is a hallmark of immune-mediated inflammatory disorders. There is an urgent need for the development of novel drugs with the capacity to impair innate immune cell overactivation under inflammatory conditions. Compelling evidence pointed out cannabinoids as potential therapeutic tools with anti-inflammatory and immunomodulatory capacity. WIN55,212-2, a non-selective synthetic cannabinoid agonist, displays protective effects in several inflammatory conditions by mechanisms partially depending on the generation of tolerogenic DCs able to induce functional regulatory T cells (Tregs). However, its immunomodulatory capacity on other myeloid cells such as monocytes and macrophages remains incompletely understood. Methods Human monocyte-derived DCs (hmoDCs) were differentiated in the absence (conventional hmoDCs) or presence of WIN55,212-2 (WIN-hmoDCs). Cells were stimulated with LPS, cocultured with naive T lymphocytes and their cytokine production and ability to induce T cell responses were analysed by ELISA or flow cytometry. To evaluate the effect of WIN55,212-2 in macrophage polarization, human and murine macrophages were activated with LPS or LPS/IFNγ, in the presence or absence of the cannabinoid. Cytokine, costimulatory molecules and inflammasome markers were assayed. Metabolic and chromatin immunoprecipitation assays were also performed. Finally, the protective capacity of WIN55,212-2 was studied in vivo in BALB/c mice after intraperitoneal injection with LPS. Results We show for the first time that the differentiation of hmoDCs in the presence of WIN55,212-2 generates tolerogenic WIN-hmoDCs that are less responsive to LPS stimulation and able to prime Tregs. WIN55,212-2 also impairs the pro-inflammatory polarization of human macrophages by inhibiting cytokine production, inflammasome activation and rescuing macrophages from pyroptotic cell death. Mechanistically, WIN55,212-2 induced a metabolic and epigenetic shift in macrophages by decreasing LPS-induced mTORC1 signaling, commitment to glycolysis and active histone marks in pro-inflammatory cytokine promoters. We confirmed these data in ex vivo LPS-stimulated peritoneal macrophages (PMΦs), which were also supported by the in vivo anti-inflammatory capacity of WIN55,212-2 in a LPS-induced sepsis mouse model. Conclusion Overall, we shed light into the molecular mechanisms by which cannabinoids exert anti-inflammatory properties in myeloid cells, which might well contribute to the future rational design of novel therapeutic strategies for inflammatory disorders.
The role of the angiography-derived index of microcirculatory resistance in the prognosis of patients with dilated cardiomyopathy

Background The coronary angiography-derived index of microcirculatory resistance (caIMR) is a novel noninvasive method to assess coronary microvascular dysfunction (CMD). However, the association between caIMR and the prognosis of patients with dilated cardiomyopathy (DCM) is unclear. We aimed to explore the role of the caIMR in evaluating the outcome of patients with DCM. Methods We consecutively and retrospectively enrolled patients with DCM in the Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, from January 2013 to January 2018. The caIMR was calculated for eligible patients. The primary end point in this study was composite events, including rehospitalization related to heart failure (HF), device implantation, heart transplantation, or cardiac death. Patients were categorized into groups based on whether they had composite events (the events and no-events groups), and differences in the baseline and end points between these two groups were analyzed. Results A total of 95 eligible patients with DCM were enrolled in the study, 36 of whom had end point events. The best cutoff values of the caIMR for the left anterior descending (LAD) artery, left circumflex (LCX) artery, and right coronary artery (RCA) were >29.8 with an area under the curve (AUC) of 0.828, >25.5 with an AUC of 0.720, and >29.7 with an AUC of 0.717, respectively (all P values <0.001). Patients were then classified into the higher caIMR group and the lower caIMR group based on the cutoff value. Kaplan-Meier analyses showed that patients with a higher caIMR had increased cumulative risks of end point events regardless of the cutoff values for the LAD, LCX, and RCA (all log-rank P values <0.001). After adjustment for confounders, Cox regression analyses indicated that LAD-caIMR was an independent risk factor for end point events in patients with DCM [hazard ratio (HR) =1.11; 95% CI: 1.06–1.16]. Conclusions A higher caIMR was significantly associated with the poor prognosis of patients with DCM.
The eNOS isoform exhibits increased expression and activation in the main olfactory bulb of nNOS knock-out mice

The main olfactory bulb (MOB) is a neural structure that processes olfactory information. Among the neurotransmitters present in the MOB, nitric oxide (NO) is particularly relevant as it performs a wide variety of functions. In this structure, NO is produced mainly by neuronal nitric oxide synthase (nNOS) but also by inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS). The MOB is considered a region with great plasticity and the different NOS also show great plasticity. Therefore, it could be considered that this plasticity could compensate for various dysfunctional and pathological alterations. We examined the possible plasticity of iNOS and eNOS in the MOB in the absence of nNOS. For this, wild-type and nNOS knock-out (nNOS-KO) mice were used. We assessed whether the absence of nNOS expression could affect the olfactory capacity of mice, followed by the analysis of the expression and distribution of the NOS isoforms using qPCR and immunofluorescence. NO production in MOB was examined using both the Griess and histochemical NADPH-diaphorase reactions. The results indicate nNOS-KO mice have reduced olfactory capacity. We observed that in the nNOS-KO animal, there is an increase both in the expression of eNOS and NADPH-diaphorase, but no apparent change in the level of NO generated in the MOB. It can be concluded that the level of eNOS in the MOB of nNOS-KO is related to the maintenance of normal levels of NO. Therefore, our findings suggest that nNOS could be essential for the proper functioning of the olfactory system.
Necessity and timing of angioplasty in acute large-vessel occlusion strokes due to intracranial atherosclerotic disease: A cohort analysis with data from the angel-ACT registry

Background The effects of angioplasty on intracranial atherosclerotic disease (ICAD)-related acute large-vessel occlusion stroke (LVOS) are unknown. We analyzed the efficacy and safety of angioplasty or stenting for ICAD-related LVOS and the optimal treatment duration. Methods Patients with ICAD-related LVOS from a prospective cohort of the Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemia Stroke registry were classified as follows: the early intraprocedural angioplasty and/or stenting (EAS) group was defined as the strategy using angioplasty or stenting without mechanical thrombectomy (MT) or one attempt of MT; the non-angioplasty and/or stenting (NAS) group, MT procedure without any angioplasty; and the late intraprocedural angioplasty and/or stenting (LAS) group, using same angioplasty techniques following two or more passes of MT. The primary endpoint was the modified Rankin Scale (mRS) score at 90 days. Other efficacy outcomes included mRS scores 0–1, mRS 0–2, and successful recanalization. Death within 90 days, and symptomatic ICH were safety endpoints. We use propensity score method to diminish the effect of treatment-selection bias. The odds ratio of recanalization rate and mRS score among EAS, NAS, and LAS groups were examined by unadjusted and adjusted logistic regression analysis among unweighted samples and inverse probability of treatment weighting (IPTW) samples. Results We divided 475 cases into three groups. Functional outcomes at 90 days were better in the EAS group than in the NAS and LAS groups. The proportion of mRS 0–1, mRS 0–2, and successful recanalization cases were the highest in the EAS group. However, after IPTW, mortality rate among the three groups were similar (EAS vs. NAS vs. LAS: 19.0 vs. 18.1 vs. 18.7%, p = 0.98) as well as symptomatic intracranial hemorrhage within 24 h however, mortality rate and symptomatic intracranial hemorrhage among the three groups were similar. Logistic regression analysis in unweighted samples and IPTW samples both showed that EAS group had better outcomes. IPTW-adjusted logistic regression analysis demonstrated that the EAS group had better outcomes (mRS 0–1) than the NAS group (adjusted odds ratio [aOR], 0.55; 95% confidence interval [CI]: 0.34–0.88, p = 0.01) and LAS (aOR, 0.39; 95% CI: 0.22–0.68, p = 0.001). Conclusions Angioplasty and/or stenting should be performed at an early stage for ICAD-related acute LVOS. Registration URL: https://www.clinicaltrials. gov; Unique identifier: NCT03370939.
A no‐hair theorem for self‐gravitating nonlinear sigma models

The coupled system of gravity and mappings φ:(M,g)→(N,G) with harmonic action and additional potential is considered. For spherically symmetric manifolds (M,g) and Riemannian manifolds (N,G) it is shown that the only static, asymptotically flat solutions of the coupled Einstein‐matter equations with regular event horizon and finite energy consist of the Schwarzschild metric and a constant map, being a zero of the non‐negative potential.
Subdomain iteration principle in transport equation problems

An iterative process similar to the Schwartz method for non-overlapping adjacent domains is constructed for solving the monoenergetic transport equation in a domain decomposed into a finite number of disjoint subdomains. Under the boundary conditions, most important for applications, the sufficient conditions are determined for the convergence of the process constructed. The paper is mainly aimed at proving the convergence of the iterative method. Let the solution to a monoenergetic transport equation (see below) be sought in a bounded three-dimensional domain V arbitrarily decomposed into a finite number of subdomains Kv, v = 1,2,. ,JV. The iterative algorithm suggested although somewhat similar to the Schwartz subdomain alternating method differs from the latter, mainly, by the fact that the subdomains Fv are non-overlapping but adjacent. It is possible in principle in our algorithm (in the Schwartz algorithm as well) to reduce the solution of a problem in the geometrically complex domain V to the successive solution of problems in geometrically simpler domains Kv. This paper is mainly aimed at proving the convergence of the iterative process. Let us consider the transport equation •f. ΩΥφ -l· σ(χ)φ σ,(χ) g(x, ΩΩ')φ(χ, Ω')φ(χ, Ω') d^ = q(x, Ω) (1) where xeK, QeU (V is a three-dimensional domain**, U is a set of unit vectors in R3); o,oseL^(V\ geL(V χ [ 1,1]), 0 (2) xeV xeV inf vrai g(x, μ) = go> 0. (3) In addition, note that the scattering indicatrix g(x, ΩΩ) (as probability density) satisfies the following normalizing identities: i 0(χ,ΩΩ'μΩ= Γ g(x9 Ju Ju (4) Originally published in Russian in Metody Resheniya Sistem Variatsionno-Raznostnykh Uravnenii (Ed. G. I. Marchuk), vol. 5, Comp. Cent. Sib. Branch, USSR Acad, Sei. , Novosibirsk, 1979, pp. 139-158. ^The term 'domain' means an open set in all cases. The boundary of the domain is everywhere assumed to be a piecewise-smooth one of the class C.
Irradiation-Induced Dysbiosis: The Compounding Effect of High-Fat Diet on Metabolic and Immune Functions in Mice

The negative impact of irradiation or diet on the metabolic and immune profiles of cancer survivors have been previously demonstrated. The gut microbiota plays a critical role in regulating these functions and is highly sensitive to cancer therapies. The aim of this study was to investigate the effect of irradiation and diet on the gut microbiota and metabolic or immune functions. We exposed C57Bl/6J mice to a single dose of 6 Gy radiation and after 5 weeks, fed them a chow or high-fat diet (HFD) for 12 weeks. We characterised their faecal microbiota, metabolic (whole body and adipose tissue) functions, and systemic (multiplex cytokine, chemokine assay, and immune cell profiling) and adipose tissue inflammatory profiles (immune cell profiling). At the end of the study, we observed a compounding effect of irradiation and diet on the metabolic and immune profiles of adipose tissue, with exposed mice fed a HFD displaying a greater inflammatory signature and impaired metabolism. Mice fed a HFD also showed altered microbiota, irrespective of irradiation status. An altered diet may exacerbate the detrimental effects of irradiation on both the metabolic and inflammatory profiles. This could have implications for the diagnosis and prevention of metabolic complications in cancer survivors exposed to radiation.