Miracle-dz/UniFAR-FTUs huggingface dataset:
Metal contents in soils of Kaffióyra, Spitsbergen

: Metal contents in the tundra soils (Gelic Regosols, Gelic Gleysols, Gelic Cambisols) of the maritime lowland of Kaffioyra, in the western Spitsbergen seashore are presented in this publication. The average heave metal contents in samples collected from the depth layer 0—130 cm are follows: Fe 2.9%, Mn 392 ppm, Zn 75 ppm, Cu 23.4 ppm, Ni 24.1 ppm, Co 7.4 ppm, Pb 12.5 ppm, Cd 0.24 ppm. The surface soil layer 0 to 25 cm is poorer in Ca and Mg than the underlying layer 25 to 130 cm. The heave metal contents like Fe, Mn, Ni and Co, are also somewhat lower in the upper layer. The enrichment indices of Pb and Cd are equal in the surface soil layer 1.16 and 1.23 respectively. Correlation coefficients between each studied element and organic carbon, and, on the other hand, soil separates < 20 jim and <2 /<m are very low.
Tauopathy

Tauopathy is a category of neurodegenerative diseases that are caused or associated with pathological tau protein. Some of the diseases are relatively common, which include Alzheimer’s disease (AD) and various Parkinsonism (PD). Tau protein is a type of micro- tubule-associated protein (MAP), encoded by the gene MAPT (microtubule-associated protein tau). Normally, tau binds to microtubule, supporting the assembling and struc- ture of cytoskeletons. However, in tauopathy, normal tau protein undergoes abnormal posttranslational modifications and detaches from microtubule; furthermore, they may aggregate forming paired helical filaments (PHF) or straight filaments (SF). Abundant PHF could be observed under microscope as fibrillary tangles. In this chapter, we will introduce the pathogenesis process of tauopathy with regard to the posttranslational modifications of the protein, the animal models, and the developing treatments against tauopathy from a clinical prospective.
Understanding the impact of group characteristics on individual’s Understanding the impact of group characteristics on individual’s privacy behavior–a systematic literature review privacy behavior–a systematic literature review

As a result of on-going digital transformation, privacy concerns and resulting privacy behavior play an important role in everyone’s life and affect both individuals as well as groups of individuals. However, there is a lack of literature on the impact of group characteristics on individual privacy behavior. Thus, the goal of this work is to provide an overview of the group-level factors that influence an individuals’ privacy behavior. By conducting a systematic literature review, we identified a total of 14 articles which investigate several factors influencing privacy behavior on the group-level. We find the theory of multilevel information privacy (TMIP) as most promising avenue to understand the role of group factors for individual privacy behavior and extend TMIP by group characteristics, group behaviors, as well as privacy concerns. Finally, even though several papers investigated the impact of group factors, there is still a big need for more research in this area.
Produtividade, crescimento e partição de matéria seca em duas cultivares de feijão - DOI: 10.4025/actasciagron.v31i4.6397

Growth and yield of Ouro Negro and BRS MG Talisma cultivars bean grains were characterized by field experiments, in field conditions, at the Coimbra Experimental Station, state of Minas Gerais, Brazil, Federal University of Vicosa, Minas Gerais State, Brazil. Bean vegetative growth and grain yield of two cultivars were evaluated. Samples at 12, 22, 36, 51, 65 and 76 days after emergence were collected to determine foliar area, biomass of different aerial components, foliar area index, absolute growth and net assimilation rates. Grain yield and its components (number of plants per area, number of pods per plant, number of grains per pod and average mass of one hundred grains) were determined at 80 days after emergence (harvest). Vegetative growth of the two cultivars was similar, although the Ouro Negro cultivar had higher accumulation rates of total dry matter, absolute growth rate, foliar area index and net assimilation rate. Relative growth rate was higher in BRS MG Talisma cultivar.
Tillering dynamics of Tanzania guinea grass under nitrogen levels and plant densities - doi: 10.4025/actascianimsci.v34i4.13382

This study evaluated the influence of nitrogen levels (N) and plant density (D) on the tillering dynamics of Tanzania guinea grass (Panicum maximum Jacq.). Treatments were arranged in a completely randomized block design with 12 treatments and two replicates in a factorial scheme (4 × 3) with four levels of N (0, 80, 160 or 320 kg ha -1 N) and three plant densities (9, 25, and 49 plant m - ²). Higher number of tillers was observed in the treatment with 9 plants m - ² and under higher levels of N, especially in the second and third generations. Still, the N influenced quadratically the appearance rate of basal and total tillers, which were also affected by plant density and interaction N × D. However, the appearance rate of aerial tiller was not influenced by factors evaluated. The mortality rate of total tiller was influenced quadratically by the nitrogen levels and plant densities. The mortality rate of basal tiller responded quadratically to plant density, whereas the mortality rate of aerial tiller increased linearly with fertilization. Pastures with low or intermediate densities fertilized with nitrogen, presented a more intense pattern of tiller renewal.
of precursors in the early postnatal dorsal white matter.

New pool cortical interneuron Abstract The migration of cortical GABAergic interneurons has been extensively studied in rodent embryos, whereas few studies have documented their postnatal migration. Combining in vivo analysis together with time-lapse imaging on cortical slices, we explored the origin and migration of cortical interneurons during the first weeks of postnatal life. Strikingly, we observed that a large pool of GAD65-GFP positive cells accumulates in the dorsal white matter region during the first postnatal week. Part of these cells divides and expresses the transcription factor paired box 6 indicating the presence of local transient amplifying precursors. The vast majority of these cells are immature interneurons expressing the neuronal marker doublecortin and partly the calcium binding protein calretinin. Time-lapse imaging reveals that GAD65-GFP positive neurons migrate from the white matter pool into the overlying anterior cingulate cortex (aCC). Some interneurons in the postnatal aCC express the same immature neuronal markers suggesting ongoing migration of calretinin positive interneurons. Finally, BrdU incorporation experiments confirm that a small fraction of interneurons located in the aCC are generated during the early postnatal period. These results altogether reveal that at postnatal ages the dorsal white matter contains a pool of interneuron precursors that divide and migrate into the aCC. cortical interneurons We found that during the first postnatal week a large pool of GAD65-GFP+ cells accumulates in the dorsal white matter region at the level of prospective aCC. We observed that a fraction of GAD65-GFP+ interneurons continues to be generated postnatally in the dorsal white matter, migrate from this site into the prospective anterior cingulate cortex (aCC) and give rise to calretinin positive cortical interneurons. Fate mapping studies using Nkx2.1-Cre mice or 5-HT3-GFP mice as well as expression of transcription factors favor a LGE/CGE origin of this pool of GAD65-GFP+ cells. These results provide evidence that a pool of dividing interneuron precursors accumulate during the first postnatal week in the medial dorsal white matter of mice and can migrate into the lower cortical layers of the anterior cingulate cortex. observed in the upper cortical layers II/III. Taken together, these data indicate that a small fraction of GAD65-GFP+ positive interneurons continue to be generated postnatally, belong to the calretinin interneuron subtype and incorporate preferentially into lower cortical layers.
between subjective time perception well-being during stressful waiting periods.

The passage of time is a subjective experience and can be easily distorted by concurrent emotions. Specifically, time seems to move particularly slowly when people are in a negative emotional state. The aim of the current studies was to evaluate the bidirectional relationship between subjective time perception and distress during stressful waiting periods, during which the slow passage of time may be particularly distressing. Across studies of undergraduate students awaiting a midterm exam grade (Study 1) and law graduates awaiting bar exam results (Studies 2 and 3), results revealed consistent links between distress and time perception across the waiting periods, with tentative evidence for bidirectional relationships between these experiences. That is, people who perceived time as moving slowly while they waited tended to report greater distress across the waiting period (particularly worry, anxiety, negative emotion, and poor coping), and people who reported greater distress tended to perceive time as moving more slowly. The links between distress and time perception suggest the possibility of downward spirals during stressful waiting periods, such that distress makes time seem to slow down, which then exacerbates distress. We discuss avenues for future research and potential remedies to derail the spiral of distress and time perception.
Analysis of Investor Intention to Invest Capital in Small and Medium Enterprises Through Peer-to-Peer Lending in Indonesia

The focus of this study is to identify factors that affecting the desires of investors or lenders to invest in Indonesian Small Medium Enterprises (SMEs) through the service provider peer-to-peer lending (P2P lending). This is because there are P2P lending that could not raise funds amounts required by the borrower (SMEs) in full and within the given deadline. This research uses quantitative method using survey to 214 respondents and data is analyzed using Partial Least Square-Structural Equation Modeling (PLS-SEM) approach. Result of analysis from this research identified the factors that influence investors’ desire to invest in Indonesian SMEs namely perceived risk and investor trust to P2P lending platform (platform trust). Perceived risk factors inversely proportional to the level of investors’ desire to invest capital. While the platform factor is directly proportional to the desire of investors to invest capital. Thus, it can be concluded that the less risk potentially arise and the higher investors’ confidence in the P2P lending platform, the higher the investors’ desire to invest.
Mechanisms of Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia

Simple Summary Chronic myeloid leukaemia (CML) is a type of blood cancer that is currently well-managed with drugs that target cancer-causing proteins. However, a significant proportion of CML patients do not respond to those drug treatments or relapse when they stop those drugs because the cancer cells in those patients stop relying on that protein and instead develop a new way to survive. Therefore, new treatment strategies may be necessary for those patients. In this review, we discuss those additional survival pathways and outline combination treatment strategies to increase responses and clinical outcomes, improving the lives of CML patients. Abstract Tyrosine kinase inhibitors (TKIs) have revolutionised the management of chronic myeloid leukaemia (CML), with the disease now having a five-year survival rate over 80%. The primary focus in the treatment of CML has been on improving the specificity and potency of TKIs to inhibit the activation of the BCR::ABL1 kinase and/or overcoming resistance driven by mutations in the BCR::ABL1 oncogene. However, this approach may be limited in a significant proportion of patients who develop TKI resistance despite the effective inhibition of BCR::ABL1. These patients may require novel therapeutic strategies that target both BCR::ABL1-dependent and BCR::ABL1-independent mechanisms of resistance. The combination treatment strategies that target alternative survival signalling, which may contribute towards BCR::ABL1-independent resistance, could be a successful strategy for eradicating residual leukaemic cells and consequently increasing the response rate in CML patients.
Arthrospira Enhances Seroclearance in Patients with Chronic Hepatitis B Receiving Nucleos(t)ide Analogue through Modulation of TNF-α/IFN-γ Profile

Chronic hepatitis B (CHB) virus infection, causing immune dysfunction and chronic hepatitis, is one of the leading risk factors for hepatocellular cancer. We investigated how Arthrospira affected hepatitis B surface antigen (HBsAg) reduction in CHB patients under continued nucleos(t)ide analogues (NA). Sixty CHB patients who had been receiving NA for at least one year with undetectable HBV DNA were randomized into three groups: control and oral Arthrospira at 3 or 6 g daily add-on therapy groups. Patients were followed up for 6 months. Oral Arthrospira-diet mice were established to investigate the possible immunological mechanism of Arthrospira against HBV. Within 6 months, mean quantitative HBsAg (qHBsAg) decreased in the oral Arthrospira add-on therapy group. Interestingly, interferon gamma (IFN-γ) increased but TNF-α, interleukin 6 (IL-6), hepatic fibrosis, and steatosis decreased in the add-on groups. In mice, Arthrospira enhanced both innate and adaptive immune system, especially natural killer (NK) cell cytotoxicity, B cell activation, and the interleukin 2 (IL-2), IFN-γ immune response. Arthrospira may modulate IL-2- and TNF-α/IFN-γ-mediated B and T cell activation to reduce HBsAg. Also, Arthrospira has the potential to restore immune tolerance and enhance HBsAg seroclearance in CHB patients through promoting T, B, and NK cell activation.
Hypertension Diagnosis with Backpropagation Neural Networks for Sustainability in Public Health

This paper presents the development of a multilayer feed-forward neural network for the diagnosis of hypertension, based on a population-based study. For the development of this architecture, several physiological factors have been considered, which are vital to determining the risk of being hypertensive; a diagnostic system can offer a solution which is not easy to determine by conventional means. The results obtained demonstrate the sustainability of health conditions affecting humanity today as a consequence of the social environment in which we live, e.g., economics, stress, smoking, alcoholism, drug addiction, obesity, diabetes, physical inactivity, etc., which leads to hypertension. The results of the neural network-based diagnostic system show an effectiveness of 90%, thus generating a high expectation in diagnosing the risk of hypertension from the analyzed physiological data.
Medication Errors in Intensive Care Units: An Umbrella Review of Control Measures

Medication errors are defined as “any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the health care professional, patient, or consumer. ” Such errors account for 30 to 50 percent of all errors in health care. The literature is replete with systematic reviews of medication errors, with a considerable number of studies focusing on systems and strategies to prevent errors in intensive care units, where these errors occur more frequently; however, to date, there appears to be no study that encapsulates and analyzes the various strategies. The aim of this study is to identify the main strategies and interventions for preventing medication errors in intensive care units through an umbrella review. The search was conducted on the following databases: PubMed, CINAHL, PsycInfo, Embase, and Scopus; it was completed in November 2020. Seven systematic reviews were included in this review, with a total of 47 studies selected. All reviews aimed to evaluate the effectiveness of a single intervention or a combination of interventions and strategies to prevent and reduce medication errors. Analysis of the results that emerged identified two macro-areas for the prevention of medication errors: systems and processes. In addition, the findings highlight the importance of adopting an integrated system of interventions in order to protect the system from harm and contain the negative consequences of errors.
Fruit Phenolic and Triterpenic Composition of Progenies of Olea europaea subsp. cuspidata, an Interesting Phytochemical Source to Be Included in Olive Breeding Programs

Olea europaea subsp. cuspidata has a relatively low commercial value due to the low size and pulp to stone ratio of its drupes compared to commercial olive cultivars. Nevertheless, this subspecies could represent a valid source of useful traits for olive breeding. In the current work, the drupe metabolic composition (secoiridoids, flavonoids, simple phenols, triterpenic acids, etc.) of a progeny of 27 cuspidata genotypes coming from free pollination and their female parent was evaluated by applying a powerful LC-MS method. A total of 62 compounds were detected within the profiles; 60 of them were annotated and 27 quantified. From a quantitative point of view, the genotypes from the progeny of cuspidata showed quite different metabolic profiles to olive common cultivars (“Arbequina”, “Frantoio”, “Koroneiki” and “Picual”) used as controls. Cuspidata drupes were richer in terms of several bioactive compounds such as rutin, hydroxytyrosol glucoside, a few interesting secoiridoids and the compounds of m/z 421 and 363. The relationships among several secondary metabolites determined in the progeny inferred from the results of both PCA and cross-correlation analysis were explained according to metabolic biosynthesis pathways in olive drupes. These outcomes underlined the potential of cuspidata genetic resources as a source of potentially interesting variability in olive breeding programs.
Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins

SARS-CoV-2 causes COVID-19, a disease curiously resulting in varied symptoms and outcomes, ranging from asymptomatic to fatal. Autoimmunity due to cross-reacting antibodies resulting from molecular mimicry between viral antigens and host proteins may provide an explanation. We computationally investigated molecular mimicry between SARS-CoV-2 Spike and known epitopes. We discovered molecular mimicry hotspots in Spike and highlight two examples with tentative autoimmune potential and implications for understanding COVID-19 complications. We show that a TQLPP motif in Spike and thrombopoietin shares similar antibody binding properties. Antibodies cross-reacting with thrombopoietin may induce thrombocytopenia, a condition observed in COVID-19 patients. Another motif, ELDKY, is shared in multiple human proteins such as PRKG1 and tropomyosin. Antibodies cross-reacting with PRKG1 and tropomyosin may cause known COVID-19 complications such as blood-clotting disorders and cardiac disease, respectively. Our findings illuminate COVID-19 pathogenesis and highlight the importance of considering autoimmune potential when developing therapeutic interventions to reduce adverse reactions.
Determinação da maturidade fisiológica de frutos de maracujazeiro amarelo colhidos na região norte do estado do Rio de Janeiro, Brasil

O trabalho teve como objetivo determinar o ponto de maturidade fisiologica dos frutos de maracujazeiro amarelo produzidos na regiao Norte Fluminense, na tentativa de se antecipar o ponto de colheita dos frutos, visando a qualidade e o aumento da vida de prateleira dos mesmos. Os frutos foram colhidos em tres periodos diferentes. A colheita 1 foi realizada aos 45 dias apos a antese (daa); a colheita 2 aos 54 daa e a colheita 3 aos 63 daa. Apos cada colheita os frutos foram lavados, secos e divididos em dois lotes para avaliacao. O primeiro lote foi avaliado imediatamente apos a colheita, e o segundo foi armazenado em câmara (23 ± 3oC e 85 ± 8% UR). Os frutos foram analisados periodicamente a cada 3 dias, quanto aos seguintes atributos de qualidade: coloracao e espessura da casca, rendimento de suco e teores de solidos soluveis (SS) e acidez titulavel (AT). Os resultados indicaram que o tempo de desenvolvimento do fruto de maracujazeiro amarelo, dentro do periodo de 45 a 63 daa, influenciou na qualidade do fruto colhido na regiao. Para as condicoes deste trabalho, o ponto ideal de colheita foi aos 63 daa, podendo, tambem, ser colhido a partir do 54o daa, porem, com perda de cerca de 21,0 % no rendimento de suco. Verificou-se, tambem, que durante a fase de amadurecimento, a manutencao dos frutos na planta retarda a evolucao da coloracao, bem como, a reducao na espessura da casca do fruto, em comparacao ao colhido e armazenado.
Approach to Cancer Pain Management in Emergency Departments: Comparison of General and Oncology Based Settings

Cancer-related pain constitutes a dominant reason for admission to emergency services, and a significant patient and healthcare challenge. Evidence points to the rising prevalence of opioid misuse in this patient group. We sought to compare drug delivery in an oncology-dedicated emergency department (OED) and a general emergency department (GED) within the same hospital. As such, we obtained patient and drug-related data for OED and GED during a designated three-month period, and compared them using Fisher’s exact test, chi-square tests and the Mann-Whitney test. In total, 584 patients had 922 visits to emergency services (OED n = 479; GED n = 443), and were given 1478 drugs (OED n = 557; GED n = 921). Pain was a prominent chief complaint among visitors to the OED (17%) and GED (21%). Approximately a fifth of all drugs used were analgesics (OED—18.5%; GED—20.4%), however, in the GED, 51.6% (n = 97) were used for non-pain-related admissions, compared with 33.0% (n = 34) in OED. Opioid usage significantly differed between emergency settings. The GED administered three times as many intravenous opioids (p <0.001), a narrower spectrum of oral and intravenous drugs (p = 0.003) and no rapid-acting opioids, significantly fewer pain adjuvants (10.9% versus 18.7%, p < 0.001), and, finally, non-guideline-recommended drugs for pain, such as meperidine and benzodiazepines. Taken together, compared with the GED, the management of cancer-related pain in the OED was more personalized, and characterized by fewer intravenous opioids, enhanced diversity in drug type, route and method of delivery. Efforts should be directed toward reduction of disparities in the treatment of cancer pain in emergency settings.