Miracle-dz/UniFAR-FTUs huggingface dataset:
Latitude, Elevation, and Mean Annual Temperature Predict Peat Organic Matter Chemistry at a Global Scale

Peatlands contain a significant fraction of global soil carbon, but how these reservoirs will respond to the changing climate is still relatively unknown. A global picture of the variations in peat organic matter chemistry will aid our ability to gauge peatland soil response to climate. The goal of this research is to test the hypotheses that (a) peat carbohydrate content, an indicator of soil organic matter reactivity, will increase with latitude and decrease with mean annual temperatures, (b) while peat aromatic content, an indicator of recalcitrance, will vary inversely, and (c) elevation will have a similar effect to latitude. We used Fourier Transform Infrared Spectroscopy to examine variations in the organic matter functional groups of 1034 peat samples collected from 10 to 20, 30–40, and 60–70 cm depths at 165 individual sites across a latitudinal gradient of 79°N–65°S and from elevations of 0–4,773 m. Carbohydrate contents of high latitude peat were significantly greater than peat originating near the equator, while aromatic content showed the opposite trend. For peat from similar latitudes but different elevations, the carbohydrate content was greater and aromatic content was lower at higher elevations. Higher carbohydrate content at higher latitudes indicates a greater potential for mineralization, whereas the chemical composition of low latitude peat is consistent with their apparent relative stability in the face of warmer temperatures. The combination of low carbohydrates and high aromatics at warmer locations near the equator suggests the mineralization of high latitude peat until reaching recalcitrance under a new temperature regime.
Selective Memory Equilibrium ∗

We study agents who are more likely to remember some experiences than others, but who update their beliefs as if the experiences they remember are the only ones that occurred. Long-run behavior is characterized by selective memory equilibrium where people choose actions that maximize their payoﬀ given their distorted recollection of the outcomes. We show how this captures the eﬀects of many biases from the literature. We also study the long-run outcomes when the expected number of recalled experiences is bounded and if an experience is recalled it is more likely to be recalled again, and agents who are only partially na¨ıve about their selective memory. Jehiel, Koster, Oprea,
Improving the Orbits of the BDS-2 IGSO and MEO Satellites with Compensating Thermal Radiation Pressure Parameters

The orbit accuracy of the navigation satellites relies on the accurate knowledge of the forces on the spacecraft, in particular the non-conservative perturbations. This study focuses on the Inclined Geosynchronous Orbit (IGSO) and Medium Earth Orbit (MEO) satellites of the regional Chinese BeiDou Navigation Satellite System (BDS-2), for which apparent deficiencies of non-conservative models are identified and evidenced in the Satellite Laser Ranging (SLR) residuals. The orbit errors derived from the empirical 5-parameter Extended CODE Orbit Model (ECOM) as well as a semi-analytical adjustable box-wing model show prominent dependency on the Sun elongation angle, even in the yaw-steering attitude mode. Hence, a periodic acceleration in the normal direction of the +X surface, presumably generated by the mismodeled thermal radiation pressure, is introduced. The SLR validations reveal that the Sun elongation angle-dependent systematic errors were significantly reduced, and the orbit accuracy was improved by 10–30% to approximately 4.5 cm and 3.0 cm for the BDS-2 IGSO and MEO satellites, respectively.
Teachers' Acceptance of Technologies for 4IR Adoption: Implementation of the UTAUT Model

Education departments all around the globe are working to increase the extent to which teachers adopt innovative technology, in order to scale up pedagogical innovation that uses new technologies. However, only a few studies have been done on the adoption and use of these tools for teaching by instructors in non-Western contexts. Therefore, the objective of this study was to examine teachers’ behavior intention to adopt and use Industry 4.0 (IR4.0) technologies in Malaysia, in accordance with the unified theory of acceptance and the use of technology (UTAUT) model. A questionnaire was employed to acquire data from a randomly selected sample of 62 primary school teachers in Malaysia. The findings reveal that only two variables (namely, the facilitating conditions, and social influence variables) have a direct impact on the behavior intention of Malaysian primary school teachers to use IR4.0 technologies. Neither effort expectancy nor performance expectancy have an impact on the intention to use these technologies. The study concludes with a set of recommendations for improving policy and research on teachers’ use of IR4 for education. This work demonstrates how the findings may assist primary school teachers to improve their understanding of 4IR adoption, and provides valuable suggestions for 4IR scholars, producers, and users.
ZIF-8 Nanoparticles Based Electrochemical Sensor for Non-Enzymatic Creatinine Detection

There is a consistent demand for developing highly sensitive, stable, cost-effective, and easy-to-fabricate creatinine sensors as creatinine is a reliable indicator of kidney and muscle-related disorders. Herein, we reported a highly sensitive and selective non-enzymatic electrochemical creatinine sensor via modifying poly(3,4 ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) coated indium tin oxide (ITO) substrate by zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs). The topography, crystallinity, and composition of the sensing electrode were characterized by field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The peroxidase-like activity of ZIF-8 nanoparticles enabled it to detect creatinine forming a zinc-creatinine composite. The electrochemical behavior and sensing performance were evaluated by amperometric and impedimetric analysis. The sensor obtained a sufficiently low limit of detection (LOD) of 30 µM in a clinically acceptable linear range (0.05 mM–2.5 mM). The interference study demonstrated high selectivity of the sensor for creatinine concerning other similar biomolecules. The sensing performance of the creatinine sensor was verified in the actual human serum, which showed excellent recovery rates. Hence, the magnificent performance of ZIF-8 based non-enzymatic creatinine sensor validated it as a responsible entity for other complicated renal markers detection.
Collection of Controlled Nanosafety Data—The CoCoN-Database, a Tool to Assess Nanomaterial Hazard

Hazard assessment is the first step in nanomaterial risk assessment. The overall number of studies on the biological effects of nanomaterials or innovative materials is steadily increasing and is above 40,000. Several databases have been established to make the amount of data manageable, but these are often highly specialized or can be used only by experts. This paper describes a new database which uses an already existing data collection of about 35,000 publications. The collection from the first phase between the years 2000 and 2013 contains about 11,000 articles and this number has been reduced by specific selection criteria. The resulting publications have been evaluated for their quality regarding the toxicological content and the experimental data have been extracted. In addition to material properties, the most important value to be extracted is the no-observed-adverse-effect-level (NOAEL) for in vivo and the no-observed-effect-concentration (NOEC) for in vitro studies. The correlation of the NOAEL/NOEC values with the nanomaterial properties and the investigated endpoints has been tested in projects such as the OECD-AOP project, where the available data for inflammatory responses have been analysed. In addition, special attention was paid to titanium dioxide particles and this example is used to show with searches for in vitro and in vivo experiments on possible lung toxicity what a typical result of a database query can look like. In this review, an emerging database is described that contains valuable information for nanomaterial hazard estimation and should aid in the progress of nanosafety research.
Still Mother after All These Years: Infants Still Prefer Mothers over Fathers (If They Have the Choice)

Fathering and mothering have changed in many ways within the last decades. Earlier studies showed a clear hierarchy in infant attachment figures with a preference for mothers. This study examined whether infants in the 21st century still prefer mothers over fathers in their expression of attachment behaviors, whether differences in parental involvement still exist, and whether this will result in differences in attachment security to mother and father. A total of 50 German families with infants between 10 and 19 months were observed in an experimental setting and during home visits. Parents reported on their involvement. The results revealed a clear hierarchy with regard to the duration of attachment behaviors directed towards mothers, followed by fathers and strangers. Mothers reported to be more involved in child care on weekdays compared to fathers. Involvement was not associated with attachment variables. Attachment security to mother and father was positively related and did not differ significantly. Infants in the 21st century in a Western country still prefer mothers over fathers in their expression of attachment behaviors. Mothers were more involved in child care than fathers. However, these differences did not result in differences in attachment security to mother and father.
Serum-Based lncRNA ANRIL, TUG1, UCA1, and HIT Expressions in Breast Cancer Patients

Breast cancer is a heterogeneous disease and is the most common and prevalent form of malignancy diagnosed in women. lncRNAs are found to be frequently dysregulated in cancer, and its expression plays a critical role in tumorigenesis. The study included 100 histopathologically confirmed, newly diagnosed untreated patients of invasive ductal carcinoma (IDC) of breast cancer patients and 100 healthy subjects. After blood collection, the serum was separated and total RNA was extracted, cDNA was synthesized using 100 ng of total RNA, and lncRNA (ANRIL, TUG1, UCA1, and HIT) expression was analyzed. Increased ANRIL (3.83-fold), TUG1 (7.64-fold), UCA1 (7.82-fold), and HIT (3.31-fold) expressions were observed in breast cancer patients compared to healthy controls. Relative expression of lncRNAs UCA-1 (p = 0.010) and HIT-1 (p < 0.0001) was significantly elevated in patients with advanced breast cancer stage compared to those with early-stage disease. While lncRNA TUG-1 expression was found to be higher in patients with early-stage tumors than those with advanced-stage tumors (p = 0.06), lncRNA ANRIL showed increased expression in patients with PR positive status (p = 0.04). However, we found a significant difference in lncRNA HIT expression in HER-2 positive breast cancer patients compared to HER-2 negative breast cancer patients (p = 0.005). An increase in the expression of serum lncRNAs ANRIL (p < 0.0001), UCA-1 (p = 0.004), and HIT (p < 0.0001) was observed in the distant organ metastatic breast cancer patients. In the ROC curve concerning lymph node involvement, the sensitivity and specificity of lncRNA HIT were 68% and 58%, respectively (p value = 0.007). In the ROC curve w.r. t. stages of disease, the sensitivity and specificity of lncRNA HIT were 80% and 50%, respectively (p value < 0.0001). Better sensitivity and specificity were observed for lncRNA HIT (sensitivity 91% and specificity 78%; p value < 0.0001) and ANRIL (sensitivity 70% and specificity 60%; p value < 0.0001) w.r. t distant organ metastases.
The Cyclic Nitroxide TEMPOL Ameliorates Oxidative Stress but Not Inflammation in a Cell Model of Parkinson’s Disease

The cyclic nitroxide TEMPOL exerts anti-oxidative and anti-inflammatory effects, and thus may provide therapeutic benefit in Parkinson’s disease (PD), in which mitochondrial dysfunction, oxidative damage and inflammation have been implicated as pathophysiological mechanisms underlying the selective loss of dopaminergic neurons. Markers of oxidative stress and inflammation were investigated in a cell model of differentiated human neuroblastoma (SH-SY5Y) cells treated with the neurotoxin, 6-hydroxydopamine (6-OHDA). Treatment with TEMPOL ameliorated 6-OHDA-mediated cytotoxicity and attenuated biomarkers of oxidative stress including: mitochondrial superoxide anion free radical production, lipid peroxidation, induction of heme oxygenase 1 (HO-1) protein expression and NFκB activation. Treatment with TEMPOL abated decreased gene expression of DRD2S and DRD2L induced by 6-OHDA indicating that TEMPOL may prevent mitochondrial dysfunction and activation of pathways that result in receptor desensitization. 6-OHDA insult decreased gene expression of the antioxidant, SOD-1, and this diminution was also mitigated by TEMPOL. Activation of NFκB increased pro-inflammatory IFNy and decreased IL-6, however, TEMPOL had no effect on these inflammation mediators. Overall, this data suggests that cyclic nitroxides may preserve dopaminergic neuronal cell viability by attenuating oxidative stress and mitochondrial dysfunction, but are unable to affect inflammatory mediators that propagate cellular damage and neurodegeneration in PD.
Teriflunomide Preserves Neuronal Activity and Protects Mitochondria in Brain Slices Exposed to Oxidative Stress

Teriflunomide (TFN) limits relapses in relapsing–remitting multiple sclerosis (RRMS) by reducing lymphocytic proliferation through the inhibition of the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) and the subsequent modulation of de novo pyrimidine synthesis. Alterations of mitochondrial function as a consequence of oxidative stress have been reported during neuroinflammation. Previously, we showed that TFN prevents alterations of mitochondrial motility caused by oxidative stress in peripheral axons. Here, we aimed to validate TFN effects on mitochondria and neuronal activity in hippocampal brain slices, in which cellular distribution and synaptic circuits are largely preserved. TFN effects on metabolism and neuronal activity were investigated by assessing oxygen partial pressure and local field potential in acute slices. Additionally, we imaged mitochondria in brain slices from the transgenic Thy1-CFP/COX8A)S2Lich/J (mitoCFP) mice using two-photon microscopy. Although TFN could not prevent oxidative stress-related depletion of ATP, it preserved oxygen consumption and neuronal activity in CNS tissue during oxidative stress. Furthermore, TFN prevented mitochondrial shortening and fragmentation of puncta-shaped and network mitochondria during oxidative stress. Regarding motility, TFN accentuated the decrease in mitochondrial displacement and increase in speed observed during oxidative stress. Importantly, these effects were not associated with neuronal viability and did not lead to axonal damage. In conclusion, during conditions of oxidative stress, TFN preserves the functionality of neurons and prevents morphological and motility alterations of mitochondria.
Conspiracy Theories and the Manufacture of Dissent: QAnon, the ‘Big Lie’, Covid-19, and the Rise of Rightwing Propaganda

This paper examines the impact of partisanship, rightwing media, and social media on attitudes about contemporary conspiracy theories. Mainstream scholarly views that ‘both sides’ of the political aisle indulge routinely in such theories are challenged. I adopt a Gramscian hegemonic framework that examines rising rightwing conspiracy theories as a manifestation of mass false consciousness in service of a political-economic system that serves upper-class interests. Issues examined include the QAnon movement, ‘big lie’ voter fraud conspiracism, and Covid-19 conspiracy theories, and the way they related to partisanship, rightwing media, and social media. I provide evidence that Republican partisanship, rightwing media consumption, and social media consumption are all significant statistical predictors of acceptance of modern conspiracy theories.
도로, 철도 부문사업의 예비타당성조사 표준지침 수정 보완 연구(A study on standard guidelines for pre-feasibility study on road and railway projects)

한국개발연구원. September, 2004. 도로, 철도 부문사업의 예비타당성조사 표준지침 수정 보완 연구(A study on standard guidelines for pre-feasibility study on road and railway projects),Reports,4,[서울]한국개발연구원,예비타당성조사 연구보고서/2004,348
NLRP3 Inflammasome in Vascular Disease: A Recurrent Villain to Combat Pharmacologically

Despite the great advances in medicine, mortality from cardiovascular diseases keeps on growing. This tendency is not likely to change considering the pandemic proportions of obesity and diabetes. Besides, the global population is more aged as life expectancy increases, and vascular aging plays a key role in the increased risk of vascular disease. In light of recent trials, namely the CANTOS study, showing the enormous potential of anti-inflammatory therapies and in particular those targeted to IL-1β, a change in therapeutical management of cardiovascular diseases is coming about. The NLRP3 inflammasome is a multiprotein complex that assembles to engage the innate immune defense by processing the maturation of pro-inflammatory cytokines IL-1β and IL-18. Substantial evidence has positioned the NLRP3 inflammasome at the center of vascular disease progression, with a particular significance in the context of aging and the low-grade chronic inflammation associated (inflammaging). Therefore, pharmacological blockade of the NLRP3 inflammasome and its end products has arisen as an extremely promising tool to battle vascular disease. In this review, we discuss the mechanisms by which the NLRP3 inflammasome contributes to vascular disease, with particular attention to the consequences of aging, and we enumerate the therapeutic options available to combat this recurrent villain.
The Bioaccumulation and Health Risk Assessment of Metals among Two Most Consumed Species of Angling Fish (Cyprinus carpio and Pseudohemiculter dispar) in Liuzhou (China): Winter Should Be Treated as a Suitable Season for Fish Angling

Wild fish caught by anglers were validated to be commonly polluted by metals, but their contamination status could be varied with changing seasons. To determine the seasonal variation in metal pollution and health risks in these fish, this study took Liuzhou City as an example to investigate the concentrations of eight metals in two dominant angling fishes (Cyprinus carpio and Pseudohemiculter dispar) collected, respectively, in winter and summer. The obtained results suggested the mean concentrations of metals in fish are overall lower in winter. Only Cr, Zn, and Cd in some fish were beyond the thresholds in summer. The significant correlations between fish length and weight and most metals suggested the biological dilution effect could exert its influence in winter. The similar distribution of metals in winter suggested that metal bioaccumulation should be manipulated by living habitats, while the inconsistent distribution of metals in summer may be related to the variation in feeding behavior. The metal pollution index (Pi) values were all below 0.2 in winter, which suggested no metal contamination in fish, but most fish were found to be mostly contaminated by Cr and Cd in summer, which was confirmed by their Pi > 0.2. The fish could be consumed freely in winter due to the total target hazard quotient (TTHQ) below 1, while the consumption of fish was not entirely safe in summer, particularly for children, due to TTHQ values that were generally beyond 1. Given the higher weekly recommended consumption of fish in winter, winter should be treated as a suitable season for fish angling.
Serological Changes in Anti-Aspergillus IgG Antibody and Development of Chronic Pulmonary Aspergillosis in Patients Treated for Pulmonary Tuberculosis

Chronic pulmonary aspergillosis (CPA) is an important infection to understand in survivors of pulmonary tuberculosis (PTB). However, limited data are available regarding CPA development and its predisposing factors following PTB. We investigated the development of, and the predisposing factors for, CPA following the completion of PTB treatment. A total of 345 patients, with newly diagnosed culture-positive PTB (between January 2015 and December 2018), were included. Enrolled cases were categorized into four groups (persistently seronegative, seroconversion, seroreversion, and persistently seropositive) according to serological changes in their anti-Aspergillus IgG antibodies before and after PTB treatment. The patients were followed up for a median of 25.8 months. Ten (10/345, 2.9%) patients developed CPA at a median of 13.5 months after treatment completion, including seven (7/24, 29.2%) and three (3/73, 4.1%) in the seroconversion and persistently seropositive groups, respectively. Upon multivariate analysis, seroconversion of anti-Aspergillus IgG antibody (adjusted hazard ratio [HR], 25.21; 95% confidence interval [CI], 6.11–103.99; p < 0.001) and diabetic status (adjusted HR, 7.54; 95% CI, 1.93–29.50; p = 0.004) were independently associated with CPA development. The development of CPA in patients with PTB was observed in 2.9% of patients during post-treatment follow-up, and this was significantly associated with both the seroconversion of anti-Aspergillus IgG antibody and diabetes characteristics.
Non-adherence to medications among patients with mental disorders attending tertiary care in Oman

Background: The primary aim of this study was to quantify the degree of non-adherence to medications among patients with mental health disorders attending a psychiatry clinic at a tertiary care hospital in Muscat, Oman.Methods: All patients attending the psychiatry clinic during the study period were invited to participate in this cross-sectional study. Demographic data and factors related to medication adherence were gathered from the participants. The level of adherence to medication was measured using the Medication Adherence Rating Scale (MARS). Results: A total of 251 patients were included in this study. The average MARS score was 5.7, indicating an overall poor level of compliance. Having an educational level of secondary school, a diagnosis of schizophrenia, having had a mental health condition for a longer time, previous history of admission to a psychiatry unit, lack of insight and poor therapeutic alliance were found to be significantly association with low level of adherence to psychiatric medications.Conclusions: Non-adherence to medications is common among patients with mental health disorders. In order to mitigate the impact of medication non-adherence in a psychiatric setting, appropriate interventions are recommended to address and manage the factors related to poor medication adherence.