Miracle-dz/UniFAR-FTUs huggingface dataset:
Diffusion approximations in collective risk theory

Collective risk theory is concerned with the random fluctations of the total assets, the risk reserve, of an insurance company. Consider a company which only writes ordinary insurance policies such as accident, disability, fire, health, and whole life. The policyholders pay premiums regularly and at certain random times make claims to the company. A policyholder's premium, the gross risk premium, is a positive amount composed of two components. The net risk premium is the component calculated to cover the payments of claims on the average, while the security risk premium, or safety loading, is the component which protects the company from large deviations of claims from the average and also allows an accumulation of capital. When a claim occurs the company pays the policyholder a positive amount called the positive risk sum.
Pediatric perioperative fluid management

The purpose of perioperative fluid management in children is to maintain adequate volume status, electrolyte level, and endocrine system homeostasis during the perioperative period. Although hypotonic solutions containing glucose have traditionally been used as pediatric maintenance fluids, recent studies have shown that isotonic balanced crystalloid solutions lower the risk of hyponatremia and metabolic acidosis perioperatively. Isotonic balanced solutions have been found to exhibit safer and more physiologically appropriate characteristics for perioperative fluid maintenance and replacement. Additionally, adding 1%–2.5% glucose to the maintenance fluid can help prevent children from developing hypoglycemia as well as lipid mobilization, ketosis, and hyperglycemia. The fasting time should be as short as possible without compromising safety; recent guidelines have recommended that the duration of clear fluid fasting be reduced to 1 h. The ongoing loss of fluid and blood as well as the free water retention induced by antidiuretic hormone secretion are unique characteristics of postoperative fluid management that must be considered. Reducing the infusion rate of the isotonic balanced solution may be necessary to avoid dilutional hyponatremia during the postoperative period. In summary, perioperative fluid management in pediatric patients requires careful attention because of the limited reserve capacity in this population. Isotonic balanced solutions appear to be the safest and most beneficial choice for most pediatric patients, considering their physiology and safety concerns.
The associations of anger and hope with project retention decisions: A case study

The role of emotions and cognition in entrepreneurship and strategic decision-making research has thus far been relatively neglected. In this research, we investigate how anger and hope may influence managers’ project retention decisions. While case studies can never test theories, our research aims to expose the Appraisal Tendency Framework (ATF) to empirical reality in a new context. A Palestinian research context characterized by extreme uncertainty is chosen as one that arguably amplifies the effects of high levels of emotion. Three businesses within a holding company were identified and twelve semi-structured interviews were conducted with managers responsible for strategic decision-making, with data analysed using Content and Thematic Analyses. The emotions of hope and anger were each independently found to be associated with project retention decisions. However, when hope and anger were experienced together, hope complemented a positive association between anger and retention. The AFT proposes that emotions with different valence (i.e., negative anger and positive hope) may be associated with corresponding thought processes (heuristic or systematic) and still result in similar behavioural outcomes. The findings also highlight implications of decision-making under uncertainty, for practitioners who may benefit from differentiating between the positive and negative influences of anger on decisions.
Treatment of pathophysiologic propagation outside of the pulmonary veins in retreatment of atrial fibrillation patients: RECOVER AF study

Abstract Aims RECOVER AF evaluated the performance of whole-chamber non-contact charge-density mapping to guide the ablation of non-pulmonary vein (PV) targets in persistent atrial fibrillation (AF) patients following either a first or second failed procedure. Methods and results RECOVER AF was a prospective, non-randomized trial that enrolled patients scheduled for a first or second ablation retreatment for recurrent AF. The PVs were assessed and re-isolated if necessary. The AF maps were used to guide the ablation of non-PV targets through elimination of pathologic conduction patterns (PCPs). Primary endpoint was freedom from AF on or off antiarrhythmic drugs (AADs) at 12 months. Patients undergoing retreatment with the AcQMap System (n = 103) were 76% AF-free at 12 months [67% after single procedure (SP)] on or off AADs (80% free from AF on AADs). Patients who had only received a pulmonary vein isolation (PVI) prior to study treatment of non-PV targets with the AcQMap System were 91% AF-free at 12 months (83% SP). No major adverse events were reported. Conclusion Non-contact mapping can be used to target and guide the ablation of PCPs beyond the PVs in persistent AF patients returning for a first or second retreatment with 76% freedom from AF at 12 months. The AF freedom was particularly high, 91% (43/47), for patients enrolled having only a prior de novo PVI, and freedom from all atrial arrhythmias for this cohort was 74% (35/47). These early results are encouraging and suggest that guiding individualized targeted ablation of PCPs may therefore be advantageous to target at the earliest opportunity in patients with persistent AF.
Risk assessment of lead exposure in radiology personnel in Menoufia hospitals, Egypt

Lead shielding is used as a guard against scatter radiation. Lead aprons can emit particulate lead into the occupational environment, resulting in the accumulation of lead dust on the skin and garments of workers. This study aimed to assess the risk of lead exposure among radiologists working in the radiology departments by estimating hair and blood lead levels. A total of 40 radiology personnel (18 wearing aprons and 22 not wearing aprons) with a comparable control group (20 personnel not working in a radiology department) underwent a pre-designed questionnaire with estimation of blood and hair levels. The hair and blood lead levels in radiologists wearing aprons were significantly higher than those of the control group and that of the radiologist not wearing aprons. The lead levels in hair and blood were correlated significantly with the duration of wearing aprons in years and weekly working hours. Health care workers in radiology departments demonstrated high hair and blood levels that were higher among workers wearing aprons than those not wearing protective equipment. Hair lead levels can be detected quickly, cheaply, and non-invasively, and could be a helpful screening test for occupational exposure.
Completing the Remedial Sequence and College-Level Credit-Bearing Math

Mathematics is the most common subject area of remedial need and the majority of remedial math students never pass a college-level credit-bearing math class. The majorities of studies that investigate this phenomenon are conducted at community colleges and use some type of regression model; however, none have used a continuation ratio model. The purpose of this study was to assess student persistence through the remedial math sequence and successfully passing a college-level credit-bearing math course using binary, cumulative, and continuation ratio logistic regression models at 2- and 4-year public institutions. Findings showed the pre-algebra grade was the strongest predictor of completing each course in the remedial sequence and passing a college-level credit-bearing math class. Also, continuation ratio logistic regression provided methodological advantages over binary and cumulative logistic regression.
Differential central integration of left versus right baroreceptor afferent input in spontaneously hypertensive rats

Background: The blood pressure (BP) regulatory impact of the arterial baroreflex has been well established in health and disease. Under normotensive conditions, we have previously demonstrated functional differences in the central processing of the left versus right aortic baroreceptor afferent input. However, it is unknown if lateralization in aortic baroreflex function remains evident during hypertension. Method: We therefore, investigated the effects of laterality on the expression of baroreflex-driven cardiovascular reflexes in a genetic model of essential hypertension, the spontaneously hypertensive rat (SHR). Anesthetized male SHRs (total n = 9) were instrumented for left, right, and bilateral aortic depressor nerve (ADN) stimulation (1–40 Hz, 0.2 ms, and 0.4 mA for 20 s) and measurement of mean arterial pressure (MAP), heart rate (HR), mesenteric vascular resistance (MVR), and femoral vascular resistance (FVR). Results: Left right, and bilateral ADN stimulation evoked frequency-dependent decreases in MAP, HR, MVR, and FVR. Left and bilateral ADN stimulation evoked greater reflex reductions in MAP, HR, MVR, and FVR compared with right-sided stimulation. Reflex bradycardia to bilateral stimulation was larger relative to both left-sided and right-sided stimulation. Reflex depressor and vascular resistance responses to bilateral stimulation mimicked those of the left-sided stimulation. These data indicate a left-side dominance in the central integration of aortic baroreceptor afferent input. Furthermore, reflex summation due to bilateral stimulation is only evident on the reflex bradycardic response, and does not drive further reductions in BP, suggesting that reflex depressor responses in the SHRs are primarily driven by changes in vascular resistance. Conclusion: Together, these results indicate that lateralization in aortic baroreflex function is not only evident under normotensive conditions but also extends to hypertensive conditions.
AMG176, an MCL-1 inhibitor, is active in pre-clinical models of aggressive B-cell lymphomas

Abstract Upregulation of the anti-apoptotic protein MCL-1 has been implicated in chemotherapy resistance and poor clinical outcomes in B-cell lymphoma (BCL). We report the activity of AMG176, a direct, selective MCL-1 inhibitor, in preclinical models of BCL. A panel of cell lines representing diffuse large B-cell lymphoma (DLBCL), double-hit lymphoma (DHL) and Burkitt’s lymphoma (BL) was selected. AMG176 induced apoptotic cell death in a dose- and time-dependent manner in all BCL cell lines. Baseline MCL-1 expression was not predictive of response. AMG176 exhibited impressive synergy with venetoclax and chemotherapeutic agents, less so with proteasomal inhibitors, and antagonism with anti-CD20 monoclonal antibodies. The activity of AMG176 could not be confirmed in murine models of BCL. Combination therapy targeting MCL-1 and BCL-2 may provide an alternative therapeutic approach in BCL, however optimal patient selection will remain the key to obtaining high response rates and tolerability.
Conicity index as an indicator of abdominal obesity in individuals with chronic kidney disease on hemodialysis

Background The conicity index is indicated as a tool for assessing the nutritional status of renal individuals undergoing hemodialysis. Thus, this study aimed to estimate the prevalence of abdominal obesity using the conicity index in individuals with chronic kidney disease undergoing hemodialysis to verify its association with sociodemographic, clinical, and lifestyle factors. Materials and methods This is a cross-sectional study with 941 individuals undergoing hemodialysis in a metropolitan area in southeastern Brazil. The conicity index was estimated and cutoffs of 1.275 and 1.285 for men and women, respectively, were used. For the analysis of the results, binary logistic regression was performed and the odds ratio (OR) was estimated with their respective confidence intervals (95% CI). Results The conicity index was high in 56.54% of men (95% CI: 34.34–70.16) and 43.46% of women (95% CI: 38.45–55.20). We found that both adult men (OR = 3.71; 95% CI: 2.27–6.07) and adult women (OR = 4.06; 95% CI: 2.41–6.84) were more likely to have abdominal obesity, as well as self-declared mixed-raced (OR: 1.74; 95% CI: 1.01–3.00) and single men (OR: 1.64; 95% CI: 1.00–2.68). Conclusions The conicity index is an important anthropometric indicator to estimate abdominal obesity in individuals with chronic kidney disease on hemodialysis.
The Effects of Expressing Empathy/Autonomy Support Using a COVID-19 Vaccination Chatbot: Experimental Study in a Sample of Belgian Adults

Background Chatbots are increasingly used to support COVID-19 vaccination programs. Their persuasiveness may depend on the conversation-related context. Objective This study aims to investigate the moderating role of the conversation quality and chatbot expertise cues in the effects of expressing empathy/autonomy support using COVID-19 vaccination chatbots. Methods This experiment with 196 Dutch-speaking adults living in Belgium, who engaged in a conversation with a chatbot providing vaccination information, used a 2 (empathy/autonomy support expression: present vs absent) × 2 (chatbot expertise cues: expert endorser vs layperson endorser) between-subject design. Chatbot conversation quality was assessed through actual conversation logs. Perceived user autonomy (PUA), chatbot patronage intention (CPI), and vaccination intention shift (VIS) were measured after the conversation, coded from 1 to 5 (PUA, CPI) and from –5 to 5 (VIS). Results There was a negative interaction effect of chatbot empathy/autonomy support expression and conversation fallback (CF; the percentage of chatbot answers “I do not understand” in a conversation) on PUA (PROCESS macro, model 1, B=–3.358, SE 1.235, t186=2.718, P=.007). Specifically, empathy/autonomy support expression had a more negative effect on PUA when the CF was higher (conditional effect of empathy/autonomy support expression at the CF level of +1SD: B=–.405, SE 0.158, t186=2.564, P=.011; conditional effects nonsignificant for the mean level: B=–0.103, SE 0.113, t186=0.914, P=.36; conditional effects nonsignificant for the –1SD level: B=0.031, SE=0.123, t186=0.252, P=.80). Moreover, an indirect effect of empathy/autonomy support expression on CPI via PUA was more negative when CF was higher (PROCESS macro, model 7, 5000 bootstrap samples, moderated mediation index=–3.676, BootSE 1.614, 95% CI –6.697 to –0.102; conditional indirect effect at the CF level of +1SD: B=–0.443, BootSE 0.202, 95% CI –0.809 to –0.005; conditional indirect effects nonsignificant for the mean level: B=–0.113, BootSE 0.124, 95% CI –0.346 to 0.137; conditional indirect effects nonsignificant for the –1SD level: B=0.034, BootSE 0.132, 95% CI –0.224 to 0.305). Indirect effects of empathy/autonomy support expression on VIS via PUA were marginally more negative when CF was higher. No effects of chatbot expertise cues were found. Conclusions The findings suggest that expressing empathy/autonomy support using a chatbot may harm its evaluation and persuasiveness when the chatbot fails to answer its users’ questions. The paper adds to the literature on vaccination chatbots by exploring the conditional effects of chatbot empathy/autonomy support expression. The results will guide policy makers and chatbot developers dealing with vaccination promotion in designing the way chatbots express their empathy and support for user autonomy.
Syngap1 Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction

Abstract SYNGAP1 haploinsufficiency in humans causes intellectual disability (ID). SYNGAP1 is highly expressed in cortical excitatory neurons and, reducing its expression in mice accelerates the maturation of excitatory synapses during sensitive developmental periods, restricts the critical period window for plasticity, and impairs cognition. However, its specific role in interneurons remains largely undetermined. In this study, we investigated the effects of conditional Syngap1 disruption in medial ganglionic eminence (MGE)-derived interneurons on hippocampal interneuron firing properties and excitatory synaptic inputs, as well as on pyramidal cell synaptic inhibition and synaptic integration. We show that conditional Syngap1 disruption in MGE-derived interneurons results in cell-specific impairment of firing properties of hippocampal Nkx2.1 fast-spiking interneurons, with enhancement of their AMPA receptor (AMPAR)-mediated excitatory synaptic inputs but compromised short-term plasticity. In contrast, regular-spiking Nkx2.1 interneurons are largely unaffected. These changes are associated with impaired pyramidal cell synaptic inhibition and enhanced summation of excitatory responses. Unexpectedly, we found that the Syngap1flox allele used in this study contains inverted loxP sites and that its targeted recombination in MGE-derived interneurons induces some cell loss during embryonic development and the reversible inversion of the sequence flanked by the loxP sites in postmitotic cells. Together, these results suggest that Syngap1 plays a role in cell-specific regulation of hippocampal interneuron function and inhibition of pyramidal cells in mice. However, because of our finding that the Syngap1flox allele used in this study contains inverted loxP sites, it will be important to further investigate interneuron function using a different Syngap1 conditional allele.
Radon Measurements in Kindergartens and Schools of Six Italian Regions

Radon concentration in 2173 schools of six Italian Regions was measured with passive dosemeters in representative surveys. Regional arithmetic and geometric means and geometric standard deviations range from 49 to 222 Bq.m -3 , from 38 to 129 Bq.m -3 and from 1.9 to 2.7, respectively. For the sake of comparison, measured values were corrected for the seasonal variations obtained from the national survey in dwellings. In some Regions, schools exhibit a higher average concentration than dwellings. However, when the floor and the geographical location of measurements is accounted for, there is better agreement. Therefore, radon measurements in schools as well as in houses may be useful for radon mapping. In some Regions, a significant proportion of schools showed radon concentration exceeding the action levels established in other countries.
Partial EC outputs by degraded cues are amplified in hippocampal CA3 circuits for retrieving stored patterns

Hippocampus is known to be important for episodic memories. Measuring of hippocampal neural ensembles is therefore important for observing hippocampal cognitive processes such as pattern completion. Previous studies on pattern completion had a limitation because the activities of CA3 were not simultaneously observed with the activities of the entorhinal cortex that project to the CA3. In addition, in previous research and modelling, distinct concepts such as pattern completion and pattern convergence have not been considered separately. Here, I used a molecular analysis technique that enables comparison of neural ensembles that evoked two successive events and evaluated neural ensembles in the hippocampal CA3 region and entorhinal cortex. By comparing neural ensembles in hippocampus and entorhinal cortex, I could obtain evidence that suggests pattern completion occurring in the CA3 region was induced by the partial input from EC. Use of the molecular-based ensemble measurement allows measuring two or more brain regions simultaneously, which can lead to insights into the cognitive functions of neural circuits.
The Fusion Rate of Cortical Bone Trajectory Screw Fixation and Pedicle Screw Fixations in L4‐5 Interbody Fusion: A Retrospective Cohort Study

Although cortical bone trajectory (CBT) screw fixation has been used for several years, the number of studies on its fusion effects is limited. Furthermore, several studies report conflicting outcomes. We aimed to compare the fusion rates and clinical efficacy of CBT screw fixation and pedicle screw (PS) fixation for L4‐L5 interbody fusion.
Evaluating the Reproducibility of Amplicon Sequencing Data Derived from Deep-Sea Cold Seep Sediment-Associated Microbiota

The reproducibility of amplicon sequencing is vital for whether the diversities of microbial communities could be accurately estimated. Thus, reproducibility influences the drawing of sound ecological conclusions. ABSTRACT Benefiting from the rapid developments and wide applications of high-throughput sequencing, great advancements have been made in investigating microbiota, which are highly diverse and play key roles in both element cycling and the energy flow of ecosystems. There have been inherent limitations of amplicon sequencing that could introduce uncertainty and raise concerns about the accuracy and reproducibility of this technology. However, studies focusing on the reproducibility of amplicon sequencing are limited, especially in characterizing microbial communities in deep-sea sediments. To evaluate reproducibility, 118 deep-sea sediment samples were used for 16S rRNA gene sequencing in technical replicates (repeated measurements of the same sample) that demonstrate the variability of amplicon sequencing. The average occurrence-based overlaps were 35.98% and 27.02% between two and among three technical replicates, respectively, whereas their abundance-based overlaps reached 84.88% and 83.16%, respectively. Although variations of alpha and beta diversity indices were found between/among technical replicates, alpha diversity indices were similar across samples, and the average beta diversity indices were much smaller for technical replicates than among samples. Moreover, clustering methods (i.e., operational taxonomic units [OTUs] and amplicon sequence variants [ASVs]) were shown to have little impact on the alpha and beta diversity patterns of microbial communities. Taken together, although there are variations between/among technical replicates, amplicon sequencing is still a powerful tool with which to reveal diversity patterns of microbiota in deep-sea sediments. IMPORTANCE The reproducibility of amplicon sequencing is vital for whether the diversities of microbial communities could be accurately estimated. Thus, reproducibility influences the drawing of sound ecological conclusions. Nevertheless, few studies have focused on the reproducibility of microbial communities that are characterized by amplicon sequencing, and studies focusing on microbiota in deep-sea sediments have been especially lacking. In this study, we evaluated the reproducibility of amplicon sequencing targeting microbiota in deep-sea sediments of cold seep. Our results revealed that there were variations between/among technical replicates and that amplicon sequencing was still a powerful tool with which to characterize the diversities of microbial communities in deep-sea sediments. This study provides valuable guidelines for the reproducibility evaluation of future work in experimental design and interpretation.