Miracle-dz/UniFAR-FTUs huggingface dataset:
Pervasive in ﬂ uence of maternal and paternal criminal offending on early childhood development: a population data linkage study

Background. Parental criminal offending is an established risk factor for offending among offspring, but little evidence is available indicating the impact of offending on early childhood functioning. We used data from a large Australian population cohort to determine associations between exposure to parental offending and a range of developmental outcomes at age 5 years. Method. Multi-generation data in 66 477 children and their parents from the New South Wales Child Development Study were combined using data linkage. Logistic and multinomial regressions tested associations between any and violent offending histories of parents (fathers, mothers, or both parents) obtained from of ﬁ cial records, and multiple measures of early childhood developmental functioning (social, emotional – behavioural, cognitive, communication and physical domains) obtained from the teacher-reported 2009 Australian Early Development Census. Results. Parental offending conferred signi ﬁ cantly increased risk of vulnerability on all domains, particularly the cognitive domain. Greater risk magnitudes were observed for offending by both parents and by mothers than by fathers, and for violent than for any offending. For all parental offending exposures, vulnerability on multiple domains (where medium to large effects were observed) was more likely than on a single domain (small to medium effects). Relationships remained signi ﬁ cant and of comparable magnitude following adjustment for sociodemographic covariates. Conclusions. The effect of parental offending on early childhood developmental outcomes is pervasive, with the stron-gest effects on functioning apparent when both parents engage in violent offending. Supporting affected families in early childhood might mitigate both early developmental vulnerability and the propensity for later delinquency among these offspring.
Imaging Findings of Pediatric Oligodendroglioma 1

Purpose : The purpose of this study is to describe the imaging characteristics of oligodendroglioma in childhood. Materials and Methods : Eight CT scans and 12 MR images were retrospectively reviewed in 12 children (mean age , 9.5years) with pathologically-proven oligoden droglioma. The most frequent symptoms were seizure and headache , with a mean dur ation before diagnosis of 21 months. Location , MR signal intensity , calcification , intratumoral hemorrhage , cystic change , peritumoral edema and contrast enhance ment were retrospectively analyzed. Results : The supratentorial location was most frequent (9 /1 2 , 75 %) and the ma jority of tumors were located peripherally or subcortically (7/9 , 78 %). On MR , most tumors demonstrated low signal intensity on T 1 W1 and high signal intensity on T2W1 ; cystic change was frequent (10 /1 2 , 83 %). Tumor enhancement was seen in 60 % of cases (6/10) , with various enhancement patterns. 1ntratumoral hemorrhage was seen in two cases. On CT , the tumors were usually hypodense and calcification was noted in two cases(2/8 , 25 %). Peritumoral edema and mass effect ofthe tumor were seen in five (5 /1 2 , 42 %). Hydrocephalus was associated in two cases. Conclusion : 1n childhood , most oligodendrogliomas demonstrate a peripherally located supratentorial mass , with frequent cystic change. Calcification or intratumoral hemorrhage were less frequent than in previously reported adult series.
LETTER TO THE EDITOR Ictal SPECT in patients with rapid eye movement sleep behaviour disorder

‘Ictal SPECT in patients with rapid eye movement sleep behaviour disorder’ by in Brain . In this article, the authors evidence brain regions activated during an episode of rapid eye movement (REM) sleep behaviour disorder (RBD) using ictal single photon emission tomography (SPECT). Four patients were included in this study: one with idiopathic RBD, one with RBD and Parkinson’s disease, and two with RBD and narcolepsy. Ictal SPECT in an RBD episode as compared to wakefulness revealed RBD-related activations in the bilat-eral premotor areas, the interhemispheric cleft, the peria-queductal area, the dorsal and ventral pons and the anterior lobe of the cerebellum in all patients, thus bypassing the basal ganglia. The also claim this to be the ﬁrst study to report results with ictal SPECT in patients with idiopathic RBD, or associated with Parkinson’s disease or narcolepsy. We here dispute this claim.
Metal concentrations in some commercially important shell in port-harcourt, Rivers State, Nigeria

Heavy metals concentration in some shell fishes ( Crassostreagasar, Senilia senilis, Tympanotonos fuscatus and Thais coronata ) sold in Port Harcourt, Rivers State, Nigeria, was investigated. Samples were procured from Creek road marketat three consecutive times and categorized into three class sizes: small (<25mm), medium (25-50mm), and large (>50mm). Samples were analysed for chromium (Cr), nickel (Ni),cadmium (Cd), lead (Pd) and zinc (Zn). The results showed that the metals (Cr, Ni, Cd, Pd and Zn) concentration (mean ± SD, µg/g, n= 10 ) in the soft tissues of all shell fishes sampled apart from Cr and Ni concentrations in T. fuscatus were within the permissible limit by the World health organisation (WHO). Chromium concentration inthe soft tissue of T. fuscatus ranged from 3.36 to 5.55 µg/g. There were no overall statistical significant difference ( p >0.05) in metals concentration in the soft tissues in all three sizes (small, medium and big) sampled for T. coronate , S. senilis , and C. gasar apart from T. fuscatus . There was significant ( p <0.05) increase with size in Cd concentration in the soft tissue of T. fuscatus .
Impairment of Gag-Speciﬁc CD8 (cid:1) T-Cell Function in Mucosal and Systemic Compartments of Simian Immunodeﬁciency Virus mac251- and Simian-Human Immunodeﬁciency Virus KU2-Infected Macaques

The identiﬁcation of several simian immunodeﬁciency virus mac251 (SIV mac251 ) cytotoxic T-lymphocyte epitopes recognized by CD8 (cid:1) T cells of infected rhesus macaques carrying the Mamu-A*01 molecule and the use of peptide-major histocompatibility complex tetrameric complexes enable the study of the frequency, breadth, functionality, and distribution of virus-speciﬁc CD8 (cid:1) T cells in the body. To begin to address these issues, we have performed a pilot study to measure the virus-speciﬁc CD8 (cid:1) and CD4 (cid:1) T-cell response in the blood, lymph nodes, spleen, and gastrointestinal lymphoid tissues of eight Mamu-A*01-positive macaques, six of those infected with SIV mac251 and two infected with the pathogenic simian-human immunodeﬁciency virus KU2. We focused on the analysis of the response to peptide p11C, C-M (Gag 181), since it was predominant in most tissues of all macaques. Five macaques restricted viral replication effectively, whereas the remaining three failed to control viremia and experienced a progressive loss of CD4 (cid:1) T cells. The frequency of the Gag 181 (p11C, C 3 M) immunodominant response varied among different tissues of the same animal and in the same tissues from different animals. We found that the functionality of this virus-speciﬁc CD8 (cid:1) T-cell population could not be assumed based on the ability to speciﬁcally bind to the Gag 181 tetramer, particularly in the mucosal tissues of some of the macaques infected by SIV mac251 that were progressing to disease. Overall, the functionality of CD8 (cid:1) tetramer-binding T cells in tissues assessed by either measurement of cytolytic activity or the ability of these cells to produce gamma interferon or tumor necrosis factor alpha was low and was even lower in the mucosal tissue than in blood or spleen of some SIV mac251 -infected animals that failed to control viremia. The data obtained in this pilot study lead to the hypothesis that disease progression may be associated with loss of virus-speciﬁc CD8 (cid:1) T-cell function.
Image Retrieval Based on Similarity Search Using the Combination of Fisher Criterion Based Genetic Algorithm

: In multimedia community, the retrieval of relevant images became the major research issue due to the wide availability of data. From the enormous review on hashing based techniques, the retrieval rate and the time complexity was high related to similarity search. So, a novel fisher criterion based genetic algorithm is incorporated. For time consumption in searching process, four feature extraction methods are expected to reduce the redundant features. As a consequence, fisher criterion based genetic algorithm is applied to optimize the feature subset by considering the fisher fitness value. The extensive experiments are conducted with four publically available datasets and compared with state-of-the-art hashing techniques.
Self-similar ﬁnite-time singularity formation in degenerate parabolic equations arising in thin-ﬁlm ﬂows

A thin liquid ﬁlm coating a planar horizontal substrate may be unstable to perturbations in the ﬁlm thickness due to unfavourable intermolecular interactions between the liquid and the substrate, which may lead to ﬁnite-time rupture. The self-similar nature of the rupture has been studied before by utilizing the standard lubrication approximation along with the Derjaguin (or disjoining) pressure formalism used to account for the intermolecular interactions, and a particular form of the disjoining pressure with exponent n = 3 has been used, namely, Π( h ) ∝ − 1 /h 3 , where h is the ﬁlm thickness. In the present study, we use a numerical continuation method to compute discrete solutions to self-similar rupture for a general disjoining pressure exponent n . We focus on axisymmetric point-rupture solutions and show that pairs of solution branches merge as n decreases, leading to a critical value n c ≈ 1 . 485 below which stable similarity solutions do not appear to exist. We verify that this observation also holds true for plane-symmetric line-rupture solutions for which the critical value turns out to be slightly larger than for the axisymmetric case, n plane c ≈ 1 . 5. Computation of the full time-dependent problem also demonstrates the loss of stable similarity solutions and the subsequent onset of cascading oscillatory structures.
Localization and quantification of leptin and leptin receptor in the canine corpus luteum , placenta and uterus during pregnancy

Leptin (Ob) was originally thought to be secreted exclusively by fat tissue regulating energy metabolism and satiety. Nowadays, it is known to be produced by many organs and to influence reproductive processes as well as other bodily functions. In the dog, little is known about Ob’s role in reproduction. To investigate the potential involvement of Ob in canine pregnancy, we determined the localization of Ob and its receptor (ObR) by in situ hybridization (ISH) and immunohistochemistry (IHC) in the corpus luteum (CL), uterus and placenta of pregnant bitches and followed the changes in their gene expression levels by RTPCR. Tissues were obtained from bitches ovariohysterectomized during preand postimplantation, mid-gestation and prepartum luteolysis. Also, uteri were collected from early pregnant dogs and their matched non-pregnant controls in diestrus. Ob and ObR mRNA and protein were detected during all stages of pregnancy in various cell types of the CL, uterus and placenta. ObR mRNA expression was increased in the pre-implantation uterus and in inter-placental sections at post-implantation. At placentation sites Ob mRNA was highest during post-implantation and prepartum luteolysis, and ObR expression was up-regulated prepartum. In the non-pregnant diestrus uterus Ob mRNA was below the detection limit, and ObR was not different between the groups. In conclusion, Ob may be involved in the establishment and maintenance of canine pregnancy in a paracrine/autocrine manner Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-165184 Dissertation Published Version Originally published at: Staub, Livia Patricia. Localization and quantification of leptin and leptin receptor in the canine corpus luteum, placenta and uterus during pregnancy. 2014, University of Zurich, Vetsuisse Faculty. Klinik für Reproduktionsmedizin, Abteilung für Kleintierreproduktion, Departement für Nutztiere der Vetsuisse-Fakultät Universität Zürich Direktor: Prof. Dr. H. Bollwein Abteilungsleiterin: Prof. Dr. I. M. Reichler Arbeit unter wissenschaftlicher Betreuung von med. vet. Orsolya Balogh PhD, Dipl. ACT Localization and quantification of leptin and leptin receptor in the canine corpus luteum, placenta and uterus during pregnancy Inaugural Dissertation zur Erlangung der Doktorwürde der Vetsuisse-Fakultät Universität Zürich
A Cartesian non‐uniform grid interpolation method for fast field evaluation on elongated domains

An algorithm for performing a fast evaluation on time harmonic fields radiated by two‐dimensional source constellations with elongated geometry is introduced. The suggested scheme attains a linear computational complexity. At the core of the algorithm is the idea of phase and amplitude compensation facilitating the conversion of fields radiated by spatially confined sources into bandlimited functions of the suitable coordinates. Thus, the fields or potentials are represented by their samples on sparse left‐side and right‐side non‐uniform Cartesian grids. These grids are employed both for the representation of outgoing fields and as targets for accumulating the incoming fields. Integrating this approach with the divide‐and‐conquer strategy, the algorithm relies on a binary hierarchical decomposition of the computational domain. The total field is computed via a two‐way multilevel process, which passes through all of the left‐side and right‐side grids, while systematically aggregating all subdomains' contributions, ending with the field interpolation back to the desired observation points. Copyright © 2012 John Wiley & Sons, Ltd.
CORRELATION STUDY OF BODY MASS INDEX AND SEVERITY OF COPD

[3 contributing factors cachexia a mechanism COPD patients. ABSTRACT The body mass index (BMI) is a prognostic factor for chronic obstructive pulmonary disease (COPD). Chronic obstructive pulmonary disease (COPD) has been redefined to indicate that, apart from the deleterious effects on the lungs, the disease is associated with clinically relevant extrapulmonary manifestations. Among the most extensively studied systemic features is unexplained weight loss, alterations in the body mass index (BMI) and in body composition. BMI has also been identified as an independent prognostic factor for COPD, with a clear association between decreased BMI and increased mortality, both in clinical patient series and in subjects from a population sample. Spirometry measurements can be used to define COPD, specifically the forced expiratory volume in the first second (FEV1), and the FEV1 to forced vital capacity (FVC) ratio. Hence a prospective and randomised study was conducted measuring B.M. I and FEV1 values from COPD patients. 94 patients were accessed for their BMI measurement. Among 94 patients 42 were found undernourished (44.68%) and 8 male and 1 female was found obese. The assessment of COPD based on FEV1 was done using a spirometer and following data were obtained. A total of 41.17% patients were found as mild, 30.88% of patients as moderate and 27.94% as severe. A correlation study was done on both FEV1 and B.M. I among the patients and an association was found i.e. with the decrease in the B.M. I there was an increase in severity of COPD condition.
MATHEMATICAL MODEL TO DESCRIBE OF SOME AMMONIUM NITRATE PHYSICAL PROPERTIES IN RELATION TO THE UNIFORMITY OF GRANULATED FERTILIZER APPLICATIONS

: This study analyzed the physical properties of a sample of ammonium nitrate: granules diameter (D), granules number (GN) by size classes according to their diameter, the total weight of the granules (TWG) on each size class, and respectively, the average weight of a granule (AWG) on each size class. The correlation analysis revealed very high positive correlation between AWG and D (r = 0.961) and high positive correlation between TGW and GN (r = 0.830). Negative correlations were recorded between GN and D (r = -0.744), AWG and GN (r = -0.796), AWG and TWG (r = -0.574), and respectively between TGW and D (r = -0.418). The distributions of the granules by size classes, and respectively the average weight of a granule according to diameter, were most accurately described by a smoothing spline model, under statistical safety conditions (confirmed by ɛ i ).
EVALUATING THE COGNITIVE AND MOOD MEASUREMENTS WHICH ARE BEING USED IN RECENT REPORTED STROKE WHILE GENERAL MEDICINE TRIALS

: Purpose: For stroke survivors, international standards prescribe cognitive and mood examinations; such measures are frequently used in treatment studies. Furthermore, there is really no agreement on the best evaluation tool (s). The purpose of this study was to evaluate use of such intellectual and affective markers in published recently stroke studies. Methods: From October 2020 to September 2021, 2 autonomous, blinded evaluators assessed increased publications encompassing general medicine (n6), gerontology/rehabilitation (n4), neurology (n5), psychiatry (n5), psychology (n5), and stroke (n4). Handsearching journals for appropriate, original research publications describing cognitive/mood evaluations in human stroke survivors was conducted. An impartial physician and psychiatric nurse reviewed the data for significance. Results: A cognition or mood assessment would be included in 498 (7 percent) of the 8840 stroke investigations. There were 416 (84 percent) cognitive assessments and 249 mood evaluation methods among the 498 papers (52 percent). There were 369 distinct evaluations utilized in all (cognitive, 303; mood, 68). Holstein's Mini-Mental State Assessment has been the most regularly utilized mental test (n190 articles, 38 percent of all publications reporting cognitive/mood results); the Hamilton Rating Scale of Anxiety has been the most regularly employed attitude measure (n44 [8 percent]). Discussion: In stroke investigations, cognitively and mood measures are rarely employed. When employed, there is significant variation, and many commonly used evaluation instruments might not even be appropriate for stroke populations. It is necessary to do research and provide advice on the best psychological assessment techniques for medical practice and research.
1 Updated approaches against SARS-CoV-2

16 The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 17 lies behind the ongoing outbreak of coronavirus disease 2019 (COVID-19). There is a 18 growing understanding of SARS-CoV-2 in the virology, epidemiology and clinical 19 management strategies. However, no anti-SARS-CoV-2 drug or vaccine has been 20 officially approved due to the absence of adequate evidence. Scientists are racing 21 towards the development of treatment for COVID-19. Recent studies have revealed 22 many attractive threptic options, even if some of them remain to be further confirmed 23 in rigorous preclinical models and clinical trials. In this minireview, we aim to 24 summarize the updated potential approaches against SARS-CoV-2. We emphasize 25 that further efforts are warranted to develop the safest and most effective approach. therapeutic targets. Further, strong pre-clinical and clinical studies are needed to determine the safe and effective treatment for COVID-19.
Role of CO 2 , climate and land use in regulating the seasonal amplitude increase of carbon ﬂuxes in terrestrial ecosystems: a multimodel analysis

We examined the net terrestrial carbon ﬂux to the atmosphere ( F TA ) simulated by nine models from the TRENDY dynamic global vegetation model project for its seasonal cycle and amplitude trend during 1961–2012. While some models exhibit similar phase and amplitude compared to atmospheric inversions, with spring drawdown and au-tumn rebound, others tend to rebound early in summer. The model ensemble mean underestimates the magnitude of the seasonal cycle by 40 % compared to atmospheric inversions. TA models disagree on of long-term experiments 83 ± 56 %, − 3 ± 74 and 20 ± 30 % to rising CO 2 , climate and land use/cover change, respectively. Seven out of the nine models suggest that CO 2 fertilization is the strongest control – with the notable exception of VEGAS, which attributes approximately equally to the three factors. Generally, all models display an enhanced seasonality over the boreal region in response to high-latitude warming, but a negative climate contribution from part of the Northern Hemisphere temperate region, and the net result is a divergence over climate change effect. Six of the nine models show that land use/cover change ampliﬁes the seasonal cycle of global F TA : some are due to forest regrowth, while others are caused by crop expansion or agricultural intensiﬁcation, as revealed by their divergent spatial patterns. We also discovered a moderate cross-model correlation between F TA amplitude increase and increase in land carbon sink ( R 2 = 0.61). Our results suggest that models can show similar results in some bench-marks with different underlying mechanisms; therefore, the spatial traits of CO 2 fertilization, climate change and land use/cover changes are crucial in determining the right mechanisms in seasonal carbon cycle change as well as mean sink change.
Combined Visual and Semi-quantitative Evaluation Improves Outcome Prediction by Early Mid-treatment 18 F-fluoro-deoxi-glucose Positron Emission Tomography in Diffuse Large B-cell Lymphoma.

The purpose of this study was to assess the predictive and prognostic value of interim FDG PET (iPET) in evaluating early response to immuno-chemotherapy after two cycles (PET-2) in diffuse large B-cell lymphoma (DLBCL) by applying two different methods of interpretation: the Deauville visual five-point scale (5-PS) and a change in standardised uptake value by semiquantitative evaluation. Methods: 145 patients with newly diagnosed DLBCL underwent pre-treatment PET (PET-0) and PET-2 assessment. PET-2 was classified according to both the visual 5-PS and percentage SUV changes ( Δ SUV). Receiver operating characteristic (ROC) analysis was performed to compare the accuracy of the two methods for predicting progression-free survival (PFS). Survival estimates, based on each method separately and combined, were calculated for iPET-positive (iPET + ) and iPET-negative (iPET–) groups and compared. Results: Both with visual and Δ SUV-based evaluations significant differences were found between the PFS of iPET– and iPET+ patient groups (p<0.001). Visually the best negative (NPV) and positive predictive value (PPV) occurred when iPET was defined as positive if Deauville score 4-5 (89% and 59%, respectively). Using the 66% Δ SUV cut-off value, reported previously, NPV and PPV were 80 and 76%, respectively. Δ SUV at 48.9% cut-off point, reported for the first time here, produced 100% specificity along with the highest sensitivity (24%). Visual and semiquantitative Δ SUV<48.9% assessment of each PET-2 gave the same PET-2 classification (positive or negative) in 70% (102/145) of all patients. This combined classification delivered NPV and PPV of 89% and 100% respectively, and all iPET + patients failed to achieve or remain in remission. Conclusion: In this large consistently treated and assessed series of DLBCL, iPET had good prognostic value interpreted either visually or semi-quantitatively. We determined that the most effective Δ SUV cut-off was at 48.9%, and that when combined with visual 5-PS assessment, a positive PET-2 was highly predictive of treatment failure. ∆