Miracle-dz/UniFAR-FTUs huggingface dataset:
Weighted Nonlinear Regression With Nonstationary Time Series

: This study investigates a weighted least squares (WLS) estimation in a nonlinear cointegrating regression. In a nonlinear regression model, where the regressors include nearly integrated arrays and stationary processes, we show that the WLS estimator has a mixed Gaussian limit, and the corresponding Studentized statistic converges to a standard normal distribution. The WLS estimator is free of the memory parameter, even when a fractional process is included in the regressors. We also consider an ordinary least squares estimation in a nonlinear cointegrating regression. Compared with the WLS estimator, the limit distribution of the ordinary least squares estimator is non-Gaussian, and depends on the nuisance parameters from the regressors when the regression function is non-integrable.
Ocriplasmin for symptomatic vitreomacular adhesion: an evidence-based review of its potential

: Vitreomacular traction is a multicategory entity that may cause substantial visual loss due to the formation of a macular hole or traction-induced tissue distortion. The advent of optical coherent tomography (OCT) has demonstrated the anatomic features of persistent vitreomacular attachment (VMA) more definitively, including in many asymptomatic or minimally symptomatic patients. The indications for intervention are unclear, since it is not possible to predict which eyes might be likely to develop progressive visual loss. This has been especially important since for many years, the only treatment option involved surgical intervention (vitrectomy) to release the persistent VMA. Recently, a pharmacolytic agent, ocriplasmin, has become available after many years of development and investigation, and may offer a feasible alternative to surgery, or even a risk/benefit ratio sufficiently favorable to offer intervention at an earlier stage of VMA. Several studies, including a large, prospective clinical trial, have established the foundation of its rationale and efficacy, providing the basis of its approval. The role for ocriplasmin in clinical practice is in the process of being determined. This paper summarizes current knowledge and status of investigations regarding ocriplasmin-induced pharmacologic vitreolysis, and offers some evidence-based considerations for its use. Core Evidence is an international, peer-reviewed open-access journal evaluating the evidence underlying the potential place in therapy of drugs throughout their development lifecycle from preclinical to post- launch. The focus of each review is to evaluate the case for a new drug or class in outcome terms in specific indications and patient groups.
Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort

Neuropsychological evidence supports the developmental taxonomy theory of antisocial behavior, suggesting that abnormal brain development distinguishes life-course-persistent from adolescence-limited antisocial behavior. Recent neuroimaging work confirmed that prospec-tively-measured life-course-persistent antisocial behavior is associated with differences in cortical brain structure. Whether this extends to subcortical brain structures remains uninvestigated. This study compared subcortical gray-matter volumes between 672 members of the Dunedin Study previously defined as exhibiting life-course-persistent, adolescence-limited or low-level antisocial behavior based on repeated assessments at ages 7 – 26 years. Gray-matter volumes of 10 subcortical structures were compared across groups. The life-course-persistent group had lower volumes of amygdala, brain stem, cerebellum, hippocampus, pallidum, thalamus, and ventral diencephalon compared to the low-antisocial group. Differences between life-course-persistent and adolescence-limited individuals were comparable in effect size to differences between life-course-persistent and low-antisocial individuals, but were not statistically significant due to less statistical power. Gray-matter volumes in adolescence-limited individuals were near the norm in this population-representative cohort and similar to volumes in low-antisocial individuals. Although this study could not establish causal links between brain volume and antisocial behavior, it constitutes new biological evidence that all people with antisocial behavior are not the same, supporting a need for greater developmental and diagnostic precision in clinical, forensic, and policy-based interventions.
Unsupervised Induction of Frame-Semantic Representations

The frame-semantic parsing task is challenging for supervised techniques, even for those few languages where relatively large amounts of labeled data are available. In this preliminary work, we consider unsupervised induction of frame-semantic representations. An existing state-of-the-art Bayesian model for PropBank-style unsupervised semantic role induction (Titov and Klementiev, 2012) is extended to jointly induce semantic frames and their roles. We evaluate the model performance both quantitatively and qualitatively by comparing the induced representation against FrameNet annotations.
THE MODERATING EFFECT OF INFORMATION TECHNOLOGY INFRASTRUCTURE ON THE RELATIONSHIP BETWEEN BUSINESS PROCESS RE-ENGINEERING STRATEGY AND PERFORMANCE OF FOOD MANUFACTURING COMPANIES IN KENYA

The main objective of the study was to evaluate the moderating effect of information technology infrastructure on the relationship between business process re-engineering strategy and performance of companies manufacturing food in Kenya. A descriptive cross-sectional survey design was adopted in data collection and analysis. Primary data was collected from respondents using a structured questionnaire, while secondary data was collected from published firm’s reports. Out of the 75 respondents targeted by the study, 44 responded forming 56.67% response rate, which was considered adequate for analysis with good representation from all the subsectors. On hypotheses testing, it was established that 64.6% of variations in the overall firm performance are explained by variations in the BPR strategy, information technology infrastructure and product variable between BPR strategy and information technology infrastructure (IT Budget*BPR Prototype). The alternate research hypothesis was therefore supported. In conclusion, the study established that information technology infrastructure positively and significantly moderates the relationship between BPR and performance of companies manufacturing food in Kenya.The results therefore support the anchoring resource advantage and resource based theories. This study has contributed in different areas including implications to theory, policy, management practice and methodological contributions. The managers should pay attention to information technology infrastructure in implementing BPR strategy for improved overall firm performance and service delivery. Lastly key methodological contribution is the use of a quantitative composite index in computing the firm performance index, the use an integrated empirical model to test the relation between BPR strategies, IT infrastructure and performance.
Therapy-related acute leukaemia with Mitoxantrone: what is the risk and can we minimise it?

Background Therapy-related acute leukaemia (TRAL) is a concern for neurologists and patients when considering treatment with Mitoxantrone for multiple sclerosis (MS). The timing of this complication, risk, mortality and relationship to exposure remain uncertain. Methods We searched literature for publications relating to Mitoxantrone in MS, reviewed publication references and handsearched abstract lists to identify case-series reporting follow-up and complications of treatment with Mitoxantrone. We combined this with our local database of 250 cases treated since 1997. We also identified all reported individual cases of TRAL and extracted data reporting exposure (dose or mg/m2), timing and outcome of TRAL. Results Case-series including 5472 patients were identified; mean dose of Mitoxantrone was 74.2 mg/m2 (range:12–120 mg/m2). TRAL was diagnosed in 0.30% (1 in 333). In 34 TRAL cases, sufficient data was available to inform analysis of exposure. Onset was a median of 18.5 months following Mitoxantrone treatment (range:4–60). Acute Myelocytic Leukaemia and Acute Promyelocytic Leukaemia represented 46.4% each of the leukaemia subtypes. Six of 25 TRAL patients, where outcome was reported, died (24%). Over 80% of cases occurred in patients exposed to >60 mg/m2, with a relative risk of 1.44 (CI95%:1.18–1.70) when comparing total dose >60 mg/m2 against <60 mg/m2 strongly suggesting a relationship between risk of TRAL and total dose.
Crater Shapes on the Saturnian Satellites: New Measurements Using Cassini Stereo Images

Introduction: Following the imaging of the surfaces of the outer planet icy satellites during the Voyager flybys, the depths of impact craters on the satellites were determined using photoclinometry and shadow length measurement [1]. Differences were identified in crater depth and simple/complex morphology transition diameter between craters on icy satellites and terrestrial planets. These differences were attributed to the differing mechanical properties between ice and “rock”, an especially important influence on the morphologies of simple, bowl-shaped craters, in addition to differences in impact velocity and surface gravity [2]. The ice component of the crusts of these satellites [3] has resulted in viscous relaxation of several of the large impact basins (>100 km diameter); gauging the extent of relaxation of such basins will bolster understanding of lithospheric rheology and the thermal states of their parent satellites [1]. The operations of the Cassini orbiter at Saturn have yielded new image datasets that exceed the Voyager datasets in quantity and resolution for each of the Saturnian satellites. For example, Voyager achieved a best resolution of 0.72 km/px at Rhea [1]; by comparison, the Cassini orbiter has imaged Rhea locally at spatial resolutions better than 10 m/px [4]. In addition, Cassini’s orbital tour has allowed it to image several areas on each satellite at different viewing angles as well as high resolutions, which was not possible for the Voyager spacecraft flybys. This study reports initial results of crater dimension measurements that use high resolution and global topography maps created using Cassini stereo images. Methods: The satellites studied to date are Rhea, Iapetus, Dione, Tethys, Mimas and Hyperion. Global topography maps with resolutions of 0.4 to 1 km/px were created for all six satellites except Hyperion, with high resolution, localized maps currently only being available for Rhea, Iapetus and Hyperion (reaching maximum resolutions of 0.142, 0.092 and 0.110 km/px respectively). Between 3 and 6 profiles were drawn to derive the mean depth and diameter across each crater. The depth was defined as the mean of the two depths measured from the base of the rim scarp to the crest of the rim. Where applicable, the diameters and heights of central peaks were also measured for each profile and mean values calculated. Results: Table 1 shows statistics relating to crater morphologies on each of the satellites. Fig. 1 displays logarithmic plots of crater depth against crater diameter for Rhea and Iapetus. Rhea is the only satellite for which a significant number of craters have been measured across the simple and complex diameter ranges to date, and for which simple/complex transition diameters have been determined. Measurements for the other satellites are currently in progress, although preliminary values for them are shown in Table 1.
Plio-Quaternary Volcanism in Italy: Petrology, Geochemistry, Geodynamics

Introduction. - The Tuscany Magmatic Province. - The Umbria-ultra-alkaline Province. - The Roman Province. - Roccamonafina Province. - The Campania Province and Mt. Vulture. - The Aeolian Arc. - Sicily Na-alkaline Province. - Tyrrhenian Sea and Sardinia. - Geodynamic Setting.
Accumulation of p62 is associated with poor prognosis in patients with triple-negative breast cancer

Background: Triple-negative breast cancer (TNBC) is associated with poor prognosis. There is an urgent need for elucidation of novel targets for TNBC therapy and to improve the prognosis of patients. The aim of this study was to evaluate the prognostic value of p62 expression in TNBC. Methods and results: Expression of p62 in tissue microarray was evaluated by immunohistochemistry in 163 patients with TNBC. The prognostic value of p62 expression was assessed by a Cox regression model adjusted for clinical characteristics. Overexpression of p62 was observed in 51 (31.3%) of 163 TNBC, and significantly correlated with advanced stage and a higher proportion of positive lymph nodes and lymphovascular invasion. A significant correlation was found between p62 expression and disease-free survival and overall survival. Accordingly, the 10-year distant metastasis-free survival for p62-overexpression and p62-underexpression patients were 58.9% and 92.5%, respectively ( P , 0.0001). Multivariate analysis indicated that p62-negative was a significant independent prognostic factor of disease-free survival ( P = 0.017), but not for overall survival ( P = 0.845) in all patients. Conclusion: Our results suggest that overexpression of p62 in TNBC is associated with a higher risk of distant metastases. This finding could open new avenues for the development of novel therapy strategies for TNBC.
Review of 2 Decades of Aneurysm-Recurrence Literature, Part 1: Reducing Recurrence after Endovascular Coiling

SUMMARY: Angiographic recurrence following endovascular therapy is an indirect measure of the potential for hemorrhage. Because patients and physicians consider recurrence to be a suboptimal outcome with some chance of future hemorrhage, much effort has been expended to reduce the incidence of recurrence. The literature regarding aneurysm recurrence following endovascular therapy, spanning 2 decades, is extensive. We will review and summarize the effort to reduce recurrence following endovascular treatment of cerebral aneurysms.
Designing Fabric with Innovative Fancy Yarns to Achieve Aesthetic Values in Men's Clothing Fabrics

The aim of the research is to designing fabric with innovative fancy yarns to achieve aesthetic values in men's clothing fabrics. In designing fancy doubled yarns, or indeed fancy yarns of any discussion are two different approaches. In the first, the ‘design’ element is likely to be concentrated upon achieving visual and tactile subjective attraction in high fashion attire. This usually entails combining a variety of plain and fancy yarns to create an exciting visual effect by blending color, texture
Faktor-faktor Yang Mempengaruhi Profitabilitas Bank Pada Bank Konvensional Yang Terdaftar Di Bursa Efek Indonesia

This study aimed to determined the factors that impact profitability of conventional banking companies listed in Indonesian Stock Exchange for the period of 2006-2015. The number of samples taken in this study was 20 banks with the sampling technique used was purposive sampling. Independent variables in this study are bank size, capital ratio, loan ratio, deposit and asset quality. The dependent variables are return on equity, return on asset, and net interest margin. From the results, bank size, capital ratio and loan ratio have a significant positive effect on ROE, ROA, and NIM. Deposit has a significant positive effect on ROE but has no significant relationship on ROA and NIM. Asset quality has a significant positive effect on NIM but has no significant relationship with ROE and ROA. In application, the bank is expected to continue to increase its size by continuing to increase its assets, and maintains the quality of capital and assets in order not to become the burden of the bank .
Exploiting the Properties of Word Embeddings to Improve the Representations of Word Sequences

In the current digital era, about 80% of the digital data which is being generated is unstructured and unlabeled natural language text. Research efforts are going on for improving text mining techniques to automatically organize, analyze, and extract useful information from the voluminous text data. In the development cycle of information retrieval and text mining applications, text representation is the most fundamental and critical step as its effectiveness directly impacts the performance of the application. Three important properties of the text representation models, which make them suitable for practical applications, are representational power, interpretability of features, and unsupervised learnability. Words and word sequences (such as sentences and documents) are the natural units of the text which are subjected to vector representation to handle the given text data. With the advent of deep learning, a family of neural language models emerged to represent words as low dimensional, distributed, and dense vectors. These word representations are popularized as word embeddings. Word embeddings are learned from huge corpora, so they encode a lot of information and have high expressive power. In the case of word sequences, traditional methods provide interpretability and support unsupervised learning, but they suffer from the issues of low representational power and scalability. The deep learning based word embedding methods are successful in producing vectors with high representational power. However, most of the deep learning based methods are notorious for human uninterpretabilty and work only in supervised learning environments. In this thesis, we propose improved word sequence representation models by exploiting the frequency distributional and spatial distributional properties of the word embeddings. Firstly, we propose an alternative word sequence representation framework in the context of longer texts such as documents. The existing vector averaging based models represent the document as a position vector in the same word embedding space. As a result, they are unable to capture the multiple aspects as well as the broad context in the document. Also, due to their low representational power, the existing approaches perform poorly at document classification. Furthermore, the document vectors obtained using such methods have uninterpretable features. In this work, we propose an improved document representation framework that captures multiple aspects of the document with interpretable features. In this framework, instead of representing a document in word embedding space, it is represented in a distinct feature space where each dimension is associated with a potential feature word that has relatively high discriminatory power. A given document is modeled as the distances between the feature words and the document. We have proposed two criteria for the selection of potential feature words and a distance function to measure the distance between the feature word and the document. Experimental results on multiple datasets
Effects of oxytocin and an oxytocin antagonist on testosterone secretion during the oestrous cycle of the goat (Capra hircus).

Oxytocin at a dose of 100 i.u. injected subcutaneously (s.c.) daily to goats between Days 3 and 6 of the oestrous cycle caused a significant increase in testosterone secretion compared with saline-treated animals. An oxytocin antagonist (0.2 micrograms/kg) injected intra-arterially between Days 12 and 18 of the oestrous cycle or simultaneously with oxytocin between Days 3 and 6 blocked the increased release of testosterone and occurrence of oestrus. It is suggested that oxytocin-induced oestrus may occur via testosterone secretion.
A Conceptual Metaphor-based Approach to Facilitate English Idiom Comprehension

The study explores the pedagogical feasibility of Conceptual Metaphor-based Approach to teaching idioms to Kurdish university-level EFL students to find out to what extent the approach enhances idiom comprehension, and whether it is better than traditionally practiced approaches accordingly. Additionally, the aim of this study is to check the L1 transfer and interference role in comprehension of idioms by the participants, and how idiom grouping under corresponding Conceptual Metaphors helps students in figuring out L1 equivalents. The quantitative data were based on and collected from testing 73 participants who were divided into an experimental and a control group. Results showed that the experimental group participants outscored the control group participants, and the difference was statistically significant. Though, the traditional group had better posttest scores in comparison to their pretest. Findings also reveal that clustering idioms around corresponding Conceptual Metaphors was more helpful than randomly listed idioms; L1 transfer was observed in the idioms that have exact equivalents or closest equivalents, and sharing the same Conceptual Metaphors was helpful in understanding and finding Kurdish idioms, particularly for the experimental group. Besides, L1 interference was noticeable in all types of idioms being exact or closest equivalent or having no equivalent linguistically. Meanwhile, literal translation was also relied on by the participants as a strategy due to probably a lack of conceptual metaphor knowledge
Notulae to the Italian alien vascular flora: 9

In this contribution, new data concerning the distribution of vascular flora alien to Italy are presented. It includes new records, confirmations, exclusions, and status changes for Italy or for Italian administrative regions. Furthermore, three new combinations are proposed. Nomenclatural and distribution updates published elsewhere are provided as Suppl. material 1.
Student Attitudes Towards Native and Non-Native English Speaker Teachers

The dichotomy between native English speaker teachers (NESTs) and non-native English speaker teachers (NNESTs), although having been challenged by current research, remains prevalent. To improve students’ learning conditions, increase equality among teachers and combat unsustainable hiring practices applied by facilitators in the educational sector, a well-rounded understanding of attitudes towards NESTs and NNESTs is a necessity. Keeping in mind the importance of regional differences and local contexts, this study aims to investigate Swedish upper secondary learners who study English as a foreign language (EFL). A questionnaire comprising 57 statements regarding NESTs and NNESTs was answered by 55 students and responses were analysed via descriptive statistics. Findings show, among others, that participants do not generally favour NESTs or NNESTs. However, some significant differences are detected, such as NESTs being perceived as teaching oral skills more effectively and NNESTs being seen as better suited to teach novice learners. Overall, Swedish EFL students perceive that pedagogical qualities are more important than nativeness.
Restarting:

We are delighted to share with you that we have not just restarted all our Seva Kutirs, but have also opened 6 new Seva Kutirs recently in Sheopur district. This takes the total number of Seva Kutirs to 163, thereby serving more than 16,000 children across 5 districts of Madhya Pradesh. The restarting process involved taking the local government authorities and the community in confidence. Our teams in all the 5 districts met with the local government officials and briefed them about our plans to restart the Seva Kutirs. As Mandla and Sheopur districts were declared Green and Orange Zones, respectively, in the month of May by the state government, we restarted the Seva Kutirs there in May. Seva Kutirs in the remaining three districts (Dewas, Sehore and Chhindwara) were restarted in the month of June.