Miracle-dz/UniFAR-FTUs huggingface dataset:
GIGANTEA supresses wilt disease resistance by down-regulating the jasmonate signaling in Arabidopsis thaliana

GIGANTEA (GI) is a plant-specific nuclear protein that plays a pleiotropic role in the growth and development of plants. GI’s involvement in circadian clock function, flowering time regulation, and various types of abiotic stress tolerance has been well documented in recent years. Here, the role of GI in response to Fusarium oxysporum (F. oxysporum) infection is investigated at the molecular level comparing Col-0 WT with the gi-100 mutant in Arabidopsis thaliana. Disease progression, photosynthetic parameters, and comparative anatomy confirmed that the spread and damage caused by pathogen infection were less severe in gi-100 than in Col-0 WT plants. F. oxysporum infection induces a remarkable accumulation of GI protein. Our report showed that it is not involved in flowering time regulation during F. oxysporum infection. Estimation of defense hormone after infection showed that jasmonic acid (JA) level is higher and salicylic acid (SA) level is lower in gi-100 compared to Col-0 WT. Here, we show that the relative transcript expression of CORONATINE INSENSITIVE1 (COI1) and PLANT DEFENSIN1.2 (PDF1.2) as a marker of the JA pathway is significantly higher while ISOCHORISMATE SYNTHASE1 (ICS1) and NON-EXPRESSOR OF PATHOGENESIS-RELATED GENES1 (NPR1), the markers of the SA pathway, are downregulated in the gi-100 mutants compared to Col-0 plants. The present study convincingly suggests that the GI module promotes susceptibility to F. oxysporum infection by inducing the SA pathway and inhibiting JA signaling in A. thaliana.
Health Care Costs Attributable to Prostate Cancer in British Columbia, Canada: A Population-Based Cohort Study

We aimed to estimate the total health care costs attributable to prostate cancer (PCa) during care phases by age, cancer stage, tumor grade, and primary treatment in the first year in British Columbia (BC), Canada. Using linked administrative health data, we followed a cohort of men aged ≥ 50 years at diagnosis with PCa between 2010 and 2017 (Cohort 1) from the diagnosis date until the date of death, the last date of observation, or 31 December 2019. Patients who died from PCa after 1 January 2010, were selected for Cohort 2. PCa attributable costs were estimated by comparing costs in patients to matched controls. Cohort 1 (n = 22,672) had a mean age of 69.9 years (SD = 8.9) and a median follow-up time of 5.2 years. Cohort 2 included 6942 patients. Mean PCa attributable costs were the highest during the first year after diagnosis ($14,307.9 [95% CI: $13,970.0, $14,645.8]) and the year before death ($9959.7 [$8738.8, $11,181.0]). Primary treatment with radiation therapy had significantly higher costs each year after diagnosis than a radical prostatectomy or other surgeries in advanced-stage PCa. Androgen deprivation therapy (and/or chemotherapy) had the highest cost for high-grade and early-stage cancer during the three years after diagnosis. No treatment group had the lowest cost. Updated cost estimates could inform economic evaluations and decision-making.
Hyperasymptotic solutions of inhomogeneous linear differential equations with a singularity of rank one

In this paper we discuss the special properties of hyperasymptotic solutions of inhomogeneous linear differential equations with a singularity of rank one. We show that the re–expansions are independent of the inhomogeneity. We illustrate how this leads to a symmetry breaking in the Stokes constants within a pair of formal solutions of a differential equation. A consequence is that Stokes constants may exactly vanish in higher–order equations, leading to dramatic simplifications in the hyperasymptotic structures. Two examples are included.
Study of the shared gene signatures of polyarticular juvenile idiopathic arthritis and autoimmune uveitis

Objective To explore the shared gene signatures and potential molecular mechanisms of polyarticular juvenile idiopathic arthritis (pJIA) and autoimmune uveitis (AU). Method The microarray data of pJIA and AU from the Gene Expression Omnibus (GEO) database were downloaded and analyzed. The GEO2R tool was used to identify the shared differentially expressed genes (DEGs) and genes of extracellular proteins were identified among them. Then, weighted gene co-expression network analysis (WGCNA) was used to identify the shared immune-related genes (IRGs) related to pJIA and AU. Moreover, the shared transcription factors (TFs) and microRNAs (miRNAs) in pJIA and AU were acquired by comparing data from HumanTFDB, hTFtarget, GTRD, HMDD, and miRTarBase. Finally, Metascape and g: Profiler were used to carry out function enrichment analyses of previously identified gene sets. Results We found 40 up-regulated and 15 down-regulated shared DEGs via GEO2R. Then 24 shared IRGs in positivity-related modules, and 18 shared IRGs in negatively-related modules were found after WGCNA. After that, 3 shared TFs (ARID1A, SMARCC2, SON) were screened. And the constructed TFs-shared DEGs network indicates a central role of ARID1A. Furthermore, hsa-miR-146 was found important in both diseases. The gene sets enrichment analyses suggested up-regulated shared DEGs, TFs targeted shared DEGs, and IRGs positivity-correlated with both diseases mainly enriched in neutrophil degranulation process, IL-4, IL-13, and cytokine signaling pathways. The IRGs negatively correlated with pJIA and AU mainly influence functions of the natural killer cell, cytotoxicity, and glomerular mesangial cell proliferation. The down-regulated shared DEGs and TFs targeted shared DEGs did not show particular functional enrichment. Conclusion Our study fully demonstrated the flexibility and complexity of the immune system disorders involved in pJIA and AU. Neutrophil degranulation may be considered the shared pathogenic mechanism, and the roles of ARID1A and MiR-146a are worthy of further in-depth study. Other than that, the importance of periodic inspection of kidney function is also noteworthy.
The power of calmness in times of the COVID-19 pandemic: The different roles of peace of mind and career calling in enhancing work engagement—A mediation analysis based on social support

Introduction The prevention and control of the COVID-19 pandemic has taken on a “New Normal” form, which necessitates a calm and peaceful social mentality. This study delves into the Chinese socioculturally oriented emotion construct of peace of mind (PoM) with regard to how it may affect employees’ work engagement in times of the pandemic. Based on the conversation of resource (COR) theory, we develop a model in which the relationship between PoM (i.e., a low-arousal positive affective state) and work engagement and the relationship between career calling (i.e., a high-arousal positive state) and work engagement are both mediated by social support. Methods A total of 292 employees from 18 companies in Wuxi and Dalian, China, were surveyed at two different time points during the COVID-19 pandemic. Results The results show that both relationships were mediated by social support; furthermore, after the mediating effect of social support on the relationship between PoM and work engagement was controlled for, the relationship between career calling and social support failed to reach significance. Discussion The findings attest to the unique advantages of PoM in boosting employees’ resource conservation and interpersonal communication in public crises. Possible implications on applying the incentive mechanism of PoM in the workplace are discussed.
The Young Massive Stellar Objects of M17

We present a multiwavelength spectroscopic survey that reveals the ionizing cluster of M17 and uncovers a population of young stellar objects (YSOs) of high mass (M ~ 5-20 M☉). The masses of the stars have been determined fairly accurately through optical or near-infrared spectral classification. We find strong circumstantial evidence for disks around the massive YSOs in the following forms: near-infrared excess, optical veiling, CO band-head emission, and/or Paδ emission. We find a direct correlation between those YSOs that show CO band-head emission at 2.3 μm and those stars in our survey that show Paδ emission; in three of the four Paδ emission stars this line is double peaked (suggestive of a bipolar wind or a rotating disk or envelope). Our data suggest that circumstellar material, possibly in the form of a disk, is prevalent among very young objects of fairly high mass. Based on considerations of disk lifetimes in other young clusters, the M17 cluster appears to be very young, perhaps less than 1 Myr. We have also identified at least nine O stars and a couple of late-O/early-B stars, most behind more than 8 mag of visible extinction using either optical or near-infrared spectral types. Several stars have inferred masses in excess of 60 M☉, and they look to be very close to the predicted zero-age main sequence with an estimated age of about 1 Myr, consistent with the age of the massive YSOs in the cluster. We have used the O stars to determine the distance to M17, which assumes the stars to lie on the zero-age main sequence (1300+ 400−200 pc). While we attempt to determine an initial mass function for the cluster, it is incomplete even at high masses because of regions of extremely high extinction (AV > 20) in the cluster. We have also used the M17 O stars to study the dust properties in the local cloud and the behavior of the diffuse interstellar bands (DIBs) along this sight line, over the extinction range of AV = 3-10. The DIBs over this extinction range show little change in spectral shape nor a significant increase in strength. We suggest the features are already saturated at small AV, or the material local to M17, where the increased extinction is being traced, does not contain the carriers of the DIB feature.
Improving the Resolution of GRACE/InSAR Groundwater Storage Estimations Using a New Subsidence Feature Weighted Combination Scheme

GRACE observations and land subsidence data derived from InSAR both assess groundwater storage changes. However, GRACE data at local scales are restricted by the coarser spatial resolution of satellite systems, and inversion of Groundwater Storage Anomalies (GWSA) by InSAR requires extensive and unavailable lithological data. Here, we propose a New Subsidence Feature Weighted Combination (NSFWC) scheme to enhance the spatial resolution of GRACE-derived GWSA from 0.5° to 0.05°. This method can not only retain the spatial distribution of groundwater changes but also reflect local details related to surface subsidence. A case study was executed to evaluate the performance of the NSFWC scheme in the Beijing Plain, which has seriously overexploited groundwater. Results showed that the simulated GWSA were consistent with in situ measurements in most regions, with a correlation coefficient of 0.85 and an RMSE of 4.41 mm/year. Additionally, there were 22 overexploited wells in the Beijing Plain, although groundwater levels generally recovered after the South to North Water Diversion Project. Simultaneously, four cones of depression were detected by the InSAR technology, where the maximum cumulative subsidence and subsidence rate achieved −198.52 mm and −53.09 mm/year, respectively. This paper provides data support and technical guarantees for small-scale groundwater resources management.
A new prediction method for tropospheric scintillation on Earth-space paths

A method of predicting scintillation fading occurring on Earth-space paths is proposed that is based on the data obtained from a low-elevation 14/11 GHz wave propagation experiment at Yamaguchi, Japan. This model includes parameters representing meteorological conditions that have not been covered in existing models and can be applied to broad regions with varying climates. The prediction accuracy of the method is evaluated using experimental data collected at four sites in the western part of Japan, as well as data reported thus far on a worldwide basis. Although data used for evaluation are limited, the model shows good prediction accuracy for frequencies from 7 to 14 GHz and elevation angles from 4 degrees to 30 degrees . >
THE INFLUENCE OF SOCIAL MEDIA MARKETING AND STORE ATMOSPHERE ON PURCHASE DECISION MEDIATED BY CONSUMER TRUST IN MILLENNIAL COFFEE SHOPS IN BANDA ACEH

This study aims to examine the Social Media Marketing and Store Atmosphere influence on Purchase Decision mediated by Consumer Trust in millennial coffee shops in Banda Aceh city, Indonesia. The population was consumers at millennial coffee shops in Banda Aceh, namely Kanarasa Coffee, Svarasukma Coffee Space, Halona Koffie, and Kuta Alam Roastery. The number of samples used was 216 people. Data were analyzed using Structural Test. The result provides the conclusions that in the millennial coffee shops in Banda Aceh, Social media marketing influences purchase decision, Store atmosphere influences purchase decision, Social media marketing influences trust, Store atmosphere influences trust, Trust influences purchase decision, Social media marketing influences purchase decision through trust as a mediator, and Store atmosphere influences purchase decision through trust as a mediator. The test also reveals that trust also functions as a partial mediator variable. These findings also prove that the model for increasing purchase decisions at millennial coffee shops in Banda Aceh is a function of strengthening social media marketing and store atmosphere, and increasing customer trust. Academically, the findings of this tested model can be used as a theoretical reference and further research to be developed.
Density-matrix theory of semiconductor lasers with relaxation broadening model-gain and gain-suppression in semiconductor lasers

The density-matrix theory of semiconductor lasers with relaxation broadening model is finally established by introducing theoretical dipole moment into previously developed treatments. The dipole moment is given theoretically by the k . p method and is calculated for various semiconductor materials. As a result, gain and gain-suppression for a variety of crystals covering wide wavelength region are calculated. It is found that the linear gain is larger for longer wavelength lasers and that the gain-suppression is much larger for longer wavelength lasers, which results in that single-mode operation is more stable in long-wavelength lasers than in shorter-wavelength lasers, in good agreement with the experiments.
Developing Green Innovations in the Wine Industry: An Applied Analysis

Winemaking is an ancestral activity characterized by its strong roots in the culture, heritage, and people of the producing regions. In addition to providing important health benefits, wine is a product that is widely accepted by society. However, the socioeconomic context is evolving at a rapid pace, and new requirements and needs are forcing companies to innovate in order to remain competitive in the markets, especially in terms of sustainability. The main aim of this paper is to analyze the relationship between green transformational leadership and green innovation, as well as the mediating effect of green motivation and green creativity in this relationship. Data were obtained from a sample of 196 Spanish companies belonging to the wine industry and, as a method of analysis, was used partial least squares structural equation modeling PLS-SEM. The results show a positive and significant relationship between green transformational leadership and green innovation in wine companies. Furthermore, green motivation and green creativity exert a mediating effect in this relationship. It is concluded that the managers of wine companies should encourage employee motivation and creativity, especially in ecological terms, by creating an environment conducive to the development of environmentally friendly innovations.
An Ultrahigh-Sensitivity Dual-Mode Microwave Sensor for Microfluidic Applications

In this letter, an ultrahigh sensitivity microwave microfluidic sensor is proposed to retrieve the dielectric properties of a liquid sample. Two metal strips in the ground plane defect are connected to the microstrip line through metallic vias. An interdigital capacitor (IDC) structure is introduced between the strips to produce a strong electric field confinement, so that the loaded liquid sample can fully interact with the field. The complex permittivity of the liquid sample affects the magnitude of the frequency offset and peak attenuation, thereby establishing a mathematical model for feature extraction of unknown liquid. The prototype of the proposed sensor is fabricated and measured. The experimental results show that compared with single-mode measurement, which only analyzes odd-mode frequency offset, dual-mode measurement can use frequency offset of odd- and even-mode to improve the sensitivity of the sensor by 43%.
N-body simulations of galaxy clustering. I. Initial conditions and galaxy collapse times

N-body simulations are used to model galaxy clustering in an expanding universe. The starting point of an N-body simulation corresponds to the epoch of protogalaxy formation when the protogalaxies become density enhancements of order unity and begin to behave like point masses. This typically occurs at a redshift of 10--30. As the models expand, the galaxies cluster; the result is remarkably similar to the observed clustering. In addition to having reasonable covariance functions the models show large empty regions containing no bright galaxies similar to those observed by Gregory and Thompson. By comparing the amplitudes of the covariance functions in the models with the observed value, we estimate the redshift of protogalaxy formation and therefore the typical galaxy collapse time T/sub c/. For H/sub 0/=50 km s/sup -1/ Mpc/sup -1/, T/sub c/approx. =2 x 10/sup 9/ yr for . cap omega. =1, and T/sub c/approx. =3 x 10/sup 9/ yr for . cap omega. =0.1, each estimate being uncertain by a factor of about 2.
Measurement Precision and Thermal and Absorption Properties of Nanostructures in Aqueous Solutions by Transient and Steady-State Thermal-Lens Spectrometry

A simultaneous steady-state and transient photothermal-lens modality was used for both the thermal and optical parameters of aqueous dispersed systems (carbon and silica nanoparticles, metal iodides, surfactants, heme proteins, albumin, and their complexes). Heat-transfer parameters (thermal diffusivity and thermal effusivity), the temperature gradient of the refractive index, light absorption, and concentration parameters were assessed. To simultaneously measure thermal and optical parameters, the time scale of thermal lensing (characteristic time, tc) should correspond to an excitation beam size of 60–300 µm, and the relative time intervals 0.5÷5tc and (5÷20)tc should be selected for transient and steady-state measurements, respectively. Dual-beam thermal-lens spectrometers in a mode-mismatched optical schematic at various excitation wavelengths were built. The spectrometers implement back-synchronized detection, providing different measurement conditions for the heating and cooling parts of the thermal-lens cycle. By varying the measurement parameters depending on the dispersed system, the conditions providing the suitable precision (replicability, repeatability, and reproducibility) of thermal-lens measurements were found; setups with a broad excitation beam (waist size, 150 and 300 μm) provide longer times to attain a thermal equilibrium and, thus, the better precision of measurements of thermal diffusivity.
Frequency scaling of depolarisation at centimetre and millimetre waves

A frequency scaling relation for the prediction of depolarisation statistics at centimetre and millimetre waves is derived by calculating the forward-scattering amplitudes of the Pruppacher-Pitter type raindrops at 33 frequencies from 3 to 40 GHz. The dependence of the frequency scaling relation on raindrop-size distributions is also discussed.
Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer’s disease and the potential role of local estrogens

Introduction Epidemiological studies show that women have a higher prevalence of Alzheimer’s disease (AD) than men. Peripheral estrogen reduction during aging in women is proposed to play a key role in this sex-associated prevalence, however, the underlying mechanism remains elusive. We previously found that transcription factor early growth response-1 (EGR1) significantly regulates cholinergic function. EGR1 stimulates acetylcholinesterase (AChE) gene expression and is involved in AD pathogenesis. We aimed to investigate whether the triple-transgenic AD (3xTg-AD) mice harboring PS1M146V, APPSwe, and TauP301L show sex differences in β-amyloid (Aβ) and hyperphosphorylated tau (p-Tau), the two primary AD hallmarks, and how local 17β-estradiol (E2) may regulate the expression of EGR1 and AChE. Methods We first sacrificed male and female 3xTg-AD mice at 3–4, 7–8, and 11–12 months and measured the levels of Aβ, p-Tau, EGR1, and AChE in the hippocampal complex. Second, we infected SH-SY5Y cells with lentivirus containing the amyloid precursor protein construct C99, cultured with or without E2 administration we measured the levels of extracellular Aβ and intracellular EGR1 and AChE. Results Female 3xTg-AD mice had higher levels of Aβ compared to males, while no p-Tau was found in either group. In SH-SY5Y cells infected with lentivirus containing the amyloid precursor protein construct C99, we observed significantly increased extracellular Aβ and decreased expression of intracellular EGR1 and AChE. By adding E2 to the culture medium, extracellular Aβ(l–42) was significantly decreased while intracellular EGR1 and AChE expression were elevated. Discussion This data shows that the 3xTg-AD mouse model can be useful for studying the human sex differences of AD, but only in regards to Ap. Furthermore, in vitro data shows local E2 may be protective for EGR1 and cholinergic functions in AD while suppressing soluble Aβ(1–42) levels. Altogether, this study provides further in vivo and in vitro data supporting the human epidemiological data indicating a higher prevalence of AD in women is related to changes in brain estrogen levels.
Investigation of H-bonded media by means of Raman scattering in terms of the fractal formalism

The structure of associated liquids is proposed to be described in terms of the fractal conception developed for amorphous media. The low-frequency region of Raman scattering spectrum for such liquids is shown to reflect fractal features of these media. Binary H-bonded solutions are taken to gain controlled modifications of the fractal parameters and at the same time to avoid dealing with a number of unknown variables. In particular the glycerol-water fractal parameter at certain concentration reflects the competition between different H-bond networks. This concentration corresponds to the density anomaly 40% concentration.