Miracle-dz/UniFAR-FTUs huggingface dataset:
One-chained form and sliding mode stabilization for a nonholonomic perturbed system

This paper deals with nonholonomic perturbed systems. A necessary and sufficient condition on the perturbation vector field is given in order to put the system into a perturbed one-chained form. Then a sliding mode control strategy (with time-varying manifolds) to stabilize the system despite the perturbation is presented. Finally, simulations on the cart-like mobile robot are given.
Effects of CeO2 Nanoparticles on Nutritional Quality of Two Crop Plants, Corn (Zea mays L.) and Soybean (Glycine max L.)

With the widespread applications of manufactured nanoparticles (NPs), there are increasing concerns about their potential adverse effects on the environment and living systems. Many studies demonstrated that NPs could significantly affect the growth and development of crop plants. However, knowledge regarding the impacts of NPs on crop quality is rather limited. In this study, the effects of CeO2 NPs (25, 75, and 225 mg Ce/kg) and CeCl3 (25 mg Ce/kg) on the nutritional components of soil-cultivated corn and soybean plants were evaluated. Both treatments tended to decrease the dry weight of grain per plant, while only 225 mg/kg CeO2 NPs on soybean and CeCl3 on corn showed statistical significance compared with the respective control. CeO2 NPs at 225 mg/kg significantly decreased the content of starch in the corn kernels by 18.2% but increased total phenols in soybean seeds by 18.4%. Neither CeO2 NPs nor CeCl3 significantly affected the contents of minerals in corn kernels except for Zn. However, in the case of soybean, the two treatments tended to decrease the contents of P, Zn, Mn, and Mo but increase the content of S. Overall, the results suggest that CeO2 NPs and Ce3+ ions showed similar but not identical effects on corn and soybean plants. CeO2 NPs affect the nutritional quality of crop plants in a species-dependent manner.
Teaching problem solving through cooperative grouping. Part 1: Group versus individual problem solving

An experiment was conducted to investigate the effects of cooperative group learning on the problem solving performance of college students in a large introductory physics course. An explicit problem solving strategy was taught in the course, and students practiced using the strategy to solve problems in mixed‐ability cooperative groups. A technique was developed to evaluate students’ problem solving performance and determine the difficulty of context‐rich problems. It was found that better problem solutions emerged through collaboration than were achieved by individuals working alone. The instructional approach improved the problem solving performance of students at all ability levels.
Childhood Traditions and Difficulties of Syrian Families under Temporary Protection in Turkey: War, Immigration, and Children

The fact that people move to another country to protect their families brings with it many difficulties. The purpose of this research is to analyze the child-rearing traditions and difficulties of a Syrian family under temporary protection with a preschool child and to reveal their experiences. The population of this research consists of the province of Kilis. Its participants are refugee families with preschool children who fled the civil war in Syria and came to Turkey. These interviews were held to gather information about the participants' social life before the war, the war period, the time of migration, settling in Turkey and child education. The codes were created by analyzing the content of the collected data, one of the qualitative analysis methods, and the codes were combined under the themes. As a result of the analysis of the data, the research findings; were gathered under four main themes: pre-war, war and migration, integration of refugee families to Turkey and child education and broken families. The research findings were discussed with the relevant studies in the literature, and suggestions were made in line with the findings.
Mathematical concepts of optical superresolution

Optical imaging beyond the diffraction limit, i.e., optical superresolution, has been studied extensively in various contexts. This paper presents an overview of some mathematical concepts relevant to superresolution in linear optical systems. Properties of bandlimited functions are surveyed and are related to both instrumental and computational aspects of superresolution. The phenomenon of superoscillation and its relation to superresolution are discussed.
Possibilities of Using De Novo Design for Generating Diverse Functional Food Enzymes

Food enzymes have an important role in the improvement of certain food characteristics, such as texture improvement, elimination of toxins and allergens, production of carbohydrates, enhancing flavor/appearance characteristics. Recently, along with the development of artificial meats, food enzymes have been employed to achieve more diverse functions, especially in converting non-edible biomass to delicious foods. Reported food enzyme modifications for specific applications have highlighted the significance of enzyme engineering. However, using direct evolution or rational design showed inherent limitations due to the mutation rates, which made it difficult to satisfy the stability or specific activity needs for certain applications. Generating functional enzymes using de novo design, which highly assembles naturally existing enzymes, provides potential solutions for screening desired enzymes. Here, we describe the functions and applications of food enzymes to introduce the need for food enzymes engineering. To illustrate the possibilities of using de novo design for generating diverse functional proteins, we reviewed protein modelling and de novo design methods and their implementations. The future directions for adding structural data for de novo design model training, acquiring diversified training data, and investigating the relationship between enzyme–substrate binding and activity were highlighted as challenges to overcome for the de novo design of food enzymes.
Supernova 1987A Revisited

Updates on research on SN 1987A are provided, with emphasis on the aftermath of the explosion: the interpretation of the light curve and spectrum, the physics of the envelope, and the interaction of the supernova with its circumstellar envelope. UVOIR light curves, gamma rays and hard X-rays, and dust formation are examined, and explosion dynamics is explored. Attention is given to optical and IR spectrum development, with emphasis on the photospheric spectrum, nebular spectrum, ionization, emission-line profiles, line strengths, and iron, cobalt, and nickel. The circumstellar environment is discussed, with special reference to progenitor mass loss, circumstellar ring and nebulosity, radio emission, and soft X-rays.
The Constitutive Activity of Spinal 5-HT6 Receptors Contributes to Diabetic Neuropathic Pain in Rats

Diabetic neuropathy is often associated with chronic pain. Serotonin type 6 (5-HT6) receptor ligands, particularly inverse agonists, have strong analgesic potential and may be new candidates for treating diabetic neuropathic pain and associated co-morbid cognitive deficits. The current study addressed the involvement of 5-HT6 receptor constitutive activity and mTOR signaling in an experimental model of diabetic neuropathic pain induced by streptozocin (STZ) injection in the rat. Here, we show that mechanical hyperalgesia and associated cognitive deficits are suppressed by the administration of 5-HT6 receptor inverse agonists or rapamycin. The 5-HT6 receptor ligands also reduced tactile allodynia in traumatic and toxic neuropathic pain induced by spinal nerve ligation and oxaliplatin injection. Furthermore, both painful and co-morbid cognitive symptoms in diabetic rats are reduced by intrathecal delivery of a cell-penetrating peptide that disrupts 5-HT6 receptor-mTOR physical interaction. These findings demonstrate the deleterious influence of the constitutive activity of spinal 5-HT6 receptors upon painful and cognitive symptoms in diabetic neuropathic pains of different etiologies. They suggest that targeting the constitutive activity of 5-HT6 receptors with inverse agonists or disrupting the 5-HT6 receptor-mTOR interaction might be valuable strategies for the alleviation of diabetic neuropathic pain and cognitive co-morbidities.
Novel Therapeutic Targets for Migraine

Migraine, a primary headache disorder involving a dysfunctional trigeminal vascular system, remains a major debilitating neurological condition impacting many patients’ quality of life. Despite the success of multiple new migraine therapies, not all patients achieve significant clinical benefits. The success of CGRP pathway-targeted therapy highlights the importance of translating the mechanistic understanding toward effective therapy. Ongoing research has identified multiple potential mechanisms in migraine signaling and nociception. In this narrative review, we discuss several potential emerging therapeutic targets, including pituitary adenylate cyclase-activating polypeptide (PACAP), adenosine, δ-opioid receptor (DOR), potassium channels, transient receptor potential ion channels (TRP), and acid-sensing ion channels (ASIC). A better understanding of these mechanisms facilitates the discovery of novel therapeutic targets and provides more treatment options for improved clinical care.
Transmission characteristics of a two-mode optical waveguide

Transient effects of signal transmission in a multimode fiber are investigated in a simple two-mode waveguide model. This paper discusses the condition on which the impulse response or base-band frequency response is defined. Several closed form expressions of the impulse, or frequency, response are derived and their physical implications discussed. The effect of mode scrambling at fiber splices are elucidated in view of the temporal (or phase) difference between modes.
Exact Solutions for Periodic Interfacial Wedge Disclination Dipoles in a Hexagonal Bicrystal

In this paper, exact closed-form solutions for the elastic stress and strain energy density of an infinite, periodic array of interfacial wedge disclination dipoles in a hexagonal bicrystal with arbitrary in-plane c-axis orientations are derived by the method of image dislocations. These solutions are shown to be of the form of the logarithm of hyperbolic and trigonometric functions of complex parameters. The strain energy of the dipole array is also calculated by numerical integration of the density field. The results show that the stress, strain energy density and strain energy all depend significantly on the orientational and material inhomogeneities, and the importance of using an anisotropic bicrystal model over a homogeneous model for calculations is emphasized. For bicrystals with symmetric c-axis orientations, it is also shown that the strain energy of the dipole array can be a strong function of the orientations, with the maximum and minimum at specific orientations that depend on the bicrystal materials.
Toward an object‐based assessment of high‐resolution forecasts of long‐lived convective precipitation in the central U.S.

Forecast models have seen vast improvements in recent years, via both increased resolutions and the ability to assimilate observational data, particularly that which has been affected by clouds and precipitation. The High‐Resolution Rapid Refresh (HRRR) model is an hourly updated, 3 km model designed for forecasting convective precipitation recently deployed for operational use over the U.S. that initializes latent heating profiles as a function of assimilated radar reflectivity. An object‐oriented verification process was developed to validate experimental HRRR convective precipitation forecasts during the 2013 warm season using the NCEP Stage IV multisensor precipitation product. A database of 467 convective precipitation features that were observed during the forecast assimilation period and their corresponding HRRR forecast precipitation features was created. This database was used to evaluate model performance over the entire forecast period, and to relate that performance to model processes, especially those related to precipitation production. Generally, HRRR precipitation is located within 30 km of the observed throughout the forecast period. Validation statistics are best at forecast hour 3, with median biases in mean, maximum, and total rainfall and raining area near 0%. Earlier in the forecast, median biases in the mean and maximum rain rate exceed 30%, with bias values often exceeding 150%. The median bias in areal extent at the beginning of the forecast is near −40%. This low areal bias and POD values <0.6 appear to be related to the model's ability to produce deep convection relative to atmospheric moisture content and concentration of rainfall in convective cores.
The effects of the return channel geometry on the aerodynamic performance of a centrifugal compressor: A numerical study

In this paper, steady RANS (Reynolds-Averaged Navier-Stokes) numerical modeling of the return system of a centrifugal compressor is carried out to investigate the effects of various geometrical parameters on the aerodynamic performance of the return system. The effects of using splitter vanes in the return-channel, the width ratio of the return channel and the diverging angle of the walls are examined. Numerical results revealed that using splitter vanes can enhance the stage averaged pressure ratio and polytropic efficiency by 0.74 and 3.21%, respectively. Results showed that increasing the width ratio can enhance the efficiency and pressure ratio near the choke region, however, it has marginal effects on the performance at low flow coefficients. Results also showed that, due to the negligible effects of the diverging angle on the stage performance, using diverging hub wall can reduce the total axial length of the multistage compressor. Finally, a new return system is designed based on the combination of the best geometrical parameters found in the current study. Simulation results demonstrated that the average pressure ratio and efficiency of the compressor have been improved by 0.99% and 4%, respectively, by the newly developed return system compared to the original design.
The UARS and EOS Microwave Limb Sounder (MLS) Experiments.

Abstract The Microwave Limb Sounder (MLS) experiments obtain measurements of atmospheric composition, temperature, and pressure by observations of millimeter- and submillimeter-wavelength thermal emission as the instrument field of view is scanned through the atmospheric limb. Features of the measurement technique include the ability to measure many atmospheric gases as well as temperature and pressure, to obtain measurements even in the presence of dense aerosol and cirrus, and to provide near-global coverage on a daily basis at all times of day and night from an orbiting platform. The composition measurements are relatively insensitive to uncertainties in atmospheric temperature. An accurate spectroscopic database is available, and the instrument calibration is also very accurate and stable. The first MLS experiment in space, launched on the (NASA) Upper Atmosphere Research Satellite (UARS) in September 1991, was designed primarily to measure stratospheric profiles of ClO, O3, H2O, and atmospheric press.
Superhumps, resonances and accretion discs

The structure of accretion discs within binary systems is shown to be influenced by the excitation of resonances within the disc. Of particular importance is that near the 3:1 commensurability with the stars' orbit. This can be used to explain the superhump phenomenon of SU UMa dwarf novae in superoutburst. This resonance can only appear for mass ratios which satisfy M 1 /M 2 ≤ 0.25-0.33, for larger mass ratios the available resonances are weaker and of the wrong form to produce the superhump phenomenon. The mass-transfer stream is shown to be an important contributor to growth rate of the resonance.
Recurrence-Free Survival in Early and Locally Advanced Large Cell Neuroendocrine Carcinoma of the Lung after Complete Tumor Resection

Background: Large Cell Neuroendocrine Carcinoma (LCNEC) is a rare subtype of lung cancer with poor clinical outcomes. Data on recurrence-free survival (RFS) in early and locally advanced pure LCNEC after complete resection (R0) are lacking. This study aims to evaluate clinical outcomes in this subgroup of patients and to identify potential prognostic markers. Methods: Retrospective multicenter study including patients with pure LCNEC stage I-III and R0 resection. Clinicopathological characteristics, RFS, and disease-specific survival (DSS) were evaluated. Univariate and multivariate analyses were performed. Results: 39 patients (M:F = 26:13), with a median age of 64 years (44–83), were included. Lobectomy (69.2%), bilobectomy (5.1%), pneumonectomy (18%), and wedge resection (7.7%) were performed mostly associated with lymphadenectomy. Adjuvant therapy included platinum-based chemotherapy and/or radiotherapy in 58.9% of cases. After a median follow-up of 44 (4–169) months, the median RFS was 39 months with 1-, 2- and 5-year RFS rates of 60.0%, 54.6%, and 44.9%, respectively. Median DSS was 72 months with a 1-, 2- and 5-year rate of 86.8, 75.9, and 57.4%, respectively. At multivariate analysis, age (cut-off 65 years old) and pN status were independent prognostic factors for both RFS (HR = 4.19, 95%CI = 1.46–12.07, p = 0.008 and HR = 13.56, 95%CI 2.45–74.89, p = 0.003, respectively) and DSS (HR = 9.30, 95%CI 2.23–38.83, p = 0.002 and HR = 11.88, 95%CI 2.28–61.84, p = 0.003, respectively). Conclusion: After R0 resection of LCNEC, half of the patients recurred mostly within the first two years of follow-up. Age and lymph node metastasis could help to stratify patients for adjuvant therapy.
Dynamics of CSBD Healing after Implementation of Dentin and Xenogeneic Bone Biomaterial

Autologous dentin is frequently used in guided bone regeneration due to its osteoinductive properties, which come from its similarity to native bone. On the other hand, the xenogeneic bone biomaterial Cerabone® serves as a biocompatible, but hardly resorbed biomaterial. During bone healing, an inflammatory, vascular, and osteogenic response occurs in which cytokines such as tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), and osteopontin (OPN) are released locally and systemically. The aim was to follow up the dynamics (on days 3, 7, 15, 21, and 30) of critical-sized bone defect (CSBD) healing after the implantation of bovine devitalized dentin, rat dentin, and xenogeneic bone biomaterial. For this purpose, histological and histomorphometric methods were employed. Additionally, serum concentrations of TNF-α, VEGF, and OPN were monitored in parallel to better understand the biomaterial-dependent systemic response in rats. At the last time interval, the results showed that the bone defect was bridged over in all three groups of biomaterials. The rat dentin group had the highest percentage of bone volume (BV/TV) and the least percentage of residual biomaterial (RB), which makes it the most optimal biomaterial for bone regeneration. Serum concentrations of the TNF-α, VEGF, and OPN refer to systemic response, which could be linked to intense bone remodeling between days 15 and 21 of the bone healing.
Expanding the Molecular Disturbances of Lipoproteins in Cardiometabolic Diseases: Lessons from Lipidomics

The increasing global burden of cardiometabolic diseases highlights the urgent clinical need for better personalized prediction and intervention strategies. Early diagnosis and prevention could greatly reduce the enormous socio-economic burden posed by these states. Plasma lipids including total cholesterol, triglycerides, HDL-C, and LDL-C have been at the center stage of the prediction and prevention strategies for cardiovascular disease; however, the bulk of cardiovascular disease events cannot be explained sufficiently by these lipid parameters. The shift from traditional serum lipid measurements that are poorly descriptive of the total serum lipidomic profile to comprehensive lipid profiling is an urgent need, since a wealth of metabolic information is currently underutilized in the clinical setting. The tremendous advances in the field of lipidomics in the last two decades has facilitated the research efforts to unravel the lipid dysregulation in cardiometabolic diseases, enabling the understanding of the underlying pathophysiological mechanisms and identification of predictive biomarkers beyond traditional lipids. This review presents an overview of the application of lipidomics in the study of serum lipoproteins in cardiometabolic diseases. Integrating the emerging multiomics with lipidomics holds great potential in moving toward this goal.
Lethal Caspase-1/4-Dependent Injury Occurs in the First Minutes of Coronary Reperfusion and Requires Calpain Activity

To study the relationship between caspase-1/4 and reperfusion injury, we measured infarct size (IS) in isolated mouse hearts undergoing 50 min global ischemia/2 h reperfusion. Starting VRT-043198 (VRT) at reperfusion halved IS. The pan-caspase inhibitor emricasan duplicated VRT’s protection. IS in caspase-1/4-knockout hearts was similarly reduced, supporting the hypothesis that caspase-1/4 was VRT’s only protective target. NLRC4 inflammasomes activate caspase-1. NLRC4 knockout hearts were not protected, eliminating NLRC4 as caspase-1/4’s activator. The amount of protection that could be achieved by only suppressing caspase-1/4 activity was limited. In wild-type (WT) hearts, ischemic preconditioning (IPC) was as protective as caspase-1/4 inhibitors. Combining IPC and emricasan in these hearts or preconditioning caspase-1/4-knockout hearts produced an additive IS reduction, indicating that more protection could be achieved by combining treatments. We determined when caspase-1/4 exerted its lethal injury. Starting VRT after 10 min of reperfusion in WT hearts was no longer protective, revealing that caspase-1/4 inflicted its injury within the first 10 min of reperfusion. Ca++ influx at reperfusion might activate caspase-1/4. We tested whether Ca++-dependent soluble adenylyl cyclase (AC10) could be responsible. However, IS in AC10−/− hearts was not different from that in WT control hearts. Ca++-activated calpain has been implicated in reperfusion injury. Calpain could be releasing actin-bound procaspase-1 in cardiomyocytes, which would explain why caspase-1/4-related injury is confined to early reperfusion. The calpain inhibitor calpeptin duplicated emricasan’s protection. Unlike IPC, adding calpain to emricasan offered no additional protection, suggesting that caspase-1/4 and calpain may share the same protective target.