Miracle-dz/UniFAR-FTUs huggingface dataset:
An Evaluation of Mastering English Series within the CBA Classroom in Cameroonian Secondary Schools

Textbooks provide an indispensable framework on which teachers and students build upon. Evaluation on its part, is a dynamic process which investigates the suitability and appropriateness of an existing practice. It is a useful device for both teachers and material writers as an underlying element in the development of innovations and modifications within the teaching/learning context. Therefore, it is obvious that textbook evaluation constitutes a crucial factor in addressing cumulative deficiencies associated with our teaching/learning institution in general and in our English Language Teaching endeavours. It has been observed that Mastering English series pose several problems to both teachers and learners of English language in Cameroon. This article sets out to investigate the Mastering English series with a focus on the students’ book 5 to find out the extent to which the book aligns with the stipulations of the CBA in Cameroon. The analysis in this study was predicated on the hypothesis that Mastering English book 5 needs great improvement to really meet both the needs of learners and the requirement of the CBA. Both the theoretical and empirical findings reveal general misgivings about Mastering English book 5 and the implementation of the CBA in the context of Cameroon.
Molecular Dynamics Simulation of Uniaxial Deformation of Glassy Amorphous Atactic Polystyrene

Molecular dynamics computer simulations have been carried out of a chemically realistic many-chain nonentangled model of glassy atactic polystyrene under the influence of uniaxial mechanical deformation. Both the initial elastic and the postyield (up to 100% of the deformation) behavior have been simulated. The Poisson ratio, the Young modulus, and the temperature dependence of the yield peak are well reproduced. The simulated strain-hardening modulus is in quantitative agreement with existing experiments. The deformationally induced anisotropy in the global and local segmental orientation is accompanied by an anisotropy of the local translational mobility: the mean-square translational displacement of the individual segments in the direction of the deformation is drastically increased just beyond the yield point as compared to the isotropic sample. The mechanical deformation of a quenched sample leads to an almost complete erasure of the aging history.
Electrostatic probe diagnostics of a planar-type radio-frequency inductively coupled oxygen plasma

An inductively coupled oxygen radio-frequency (13.56 MHz) discharge is investigated based on modeling and experiment. Experimental measurement is done at a range of gas pressure of 1–30 mTorr, and rf power of 100–1000 W. We measure most of the important plasma parameters such as the densities of charged species, electron temperature, plasma potential, and electron energy distribution function. The measured values are compared with the results of the spatially averaged global model. We observe a generally good agreement between the modeling and the experiment. The scaling features, the transition of the operating region, and the radial distributions of charged species are also discussed.
Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress

Osteoarthritis (OA), characterized as an end-stage syndrome caused by risk factors accumulated with age, significantly impacts quality of life in the elderly. Circular RNAs (circRNAs) are receiving increasing attention regarding their role in OA progression and development; however, their role in the regulation of age-induced and oxidative stress-related OA remains unclear. Methods: Herein, we explored oxidative stress in articular cartilage obtained from patients of different ages. The presence of circRSU1 was detected using RNA sequencing of H2O2-stimulated primary human articular chondrocytes (HCs), and validated in articular cartilage and HCs using fluorescence in situ hybridization (FISH) staining. miR-93-5p and mitogen-activated protein kinase kinase kinase 8 (MAP3K8) were identified as interactive circRSU1 partners based on annotation and target prediction databases, and their associations were identified through dual-luciferase reporter analysis. The effect of the circRSU1-miR-93-5p-MAP3K8 axis on HCs was confirmed using western blot, quantitative real-time PCR (qRT-PCR), enzyme-linked immunosorbent assay (ELISA), immunofluorescence, and reactive oxygen species (ROS) analyses. CircRSU1 and its mutant were ectopically expressed in mice to assess their effects in destabilization of the medial meniscus (DMM) in mice. Results: We found a marked upregulation of circRSU1 in H2O2-treated HCs and OA articular cartilage from elderly individuals. circRSU1 was induced by IL-1β and H2O2 stimulation, and it subsequently regulated oxidative stress-triggered inflammation and extracellular matrix (ECM) maintenance in HCs, by modulating the MEK/ERK1/2 and NF-κB cascades. Ectopic expression of circRSU1 in mouse joints promoted the production of ROS and loss of ECM, which was rescued by mutation of the mir-93-5p target sequence in circRSU1. Conclusion: We identified a circRSU1-miR-93-5p-MAP3K8 axis that modulates the progression of OA via oxidative stress regulation, which could serve as a potential target for OA therapy.
Impact of the COVID-19 Epidemic on Eating Habits and Lifestyle : An East Nusa Tenggara Survey

The Large Scale Social Restrictions, implementation has been regulated in Government Regulation (PP No 21 of 2020) signed by the President of the Republic of Indonesia and along with the Minister of Health of Republic of Indonesia's Regulation (Permenkes No 9 of 2020) concerning Large-Scale Social Limitation Guidelines in the Context of the Handling of COVID-19 This is undoubtedly to overcome the problem of dissemination COVID-19 This research aimed to find out the lifestyle of the people in East Nusa Tenggara, Indonesia, during the emergency response phase of COVID-19 Methods of data collection were executed by filling out the lifestyle questionnaires that were previously prepared and uploaded in the Google Form toward the population aged over 16 years in East Nusa Tenggara, Indonesia This research was conducted by a cross-sectional study method According to the results of data analysis, about 191 respondents were involved in this study Information about COVID-19 was mostly obtained from the internet or social media was 71 20% Daily consumption of vegetables and fruit was 39 27% Around 47 64% of respondents experienced a change of habit, such as sometimes do sunbathe, and 30 89% of respondents increased physical activity frequency more than three times a week The 98 43% of East Nusa Tenggara society tended to wear masks outside of their house, and 85 34% always wash their hands using soap The prevalence of daily fresh food consumption during this virus pandemic was 77 49%, and instant food products were 2 62% every day Factors that changed during the Covid-19 virus pandemic were smoking, physical activity, consumption, washing hands, wearing masks, sunbathing, and processed foods consumption
Projected Impact of Mid-21st Century Climate Change on Wildfire Hazard in a Major Urban Watershed outside Portland, Oregon USA

Characterizing wildfire regimes where wildfires are uncommon is challenged by a lack of empirical information. Moreover, climate change is projected to lead to increasingly frequent wildfires and additional annual area burned in forests historically characterized by long fire return intervals. Western Oregon and Washington, USA (westside) have experienced few large wildfires (fires greater than 100 hectares) the past century and are characterized to infrequent large fires with return intervals greater than 500 years. We evaluated impacts of climate change on wildfire hazard in a major urban watershed outside Portland, OR, USA. We simulated wildfire occurrence and fire regime characteristics under contemporary conditions (1992–2015) and four mid-century (2040–2069) scenarios using Representative Concentration Pathway (RCP) 8.5. Simulated mid-century fire seasons expanded in most scenarios, in some cases by nearly two months. In all scenarios, average fire size and frequency projections increased significantly. Fire regime characteristics under the hottest and driest mid-century scenarios illustrate novel disturbance regimes which could result in permanent changes to forest structure and composition and the provision of ecosystem services. Managers and planners can use the range of modeled outputs and simulation results to inform robust strategies for climate adaptation and risk mitigation.
A Qualitative Numerical Study on Catalytic Hydrogenation of Nitrobenzene in Gas-Liquid Taylor Flow with Detailed Reaction Mechanism

While the number of computational studies considering two-phase flows in microfluidic systems with or without mass transfer is increasing, numerical studies incorporating chemical reactions are still rare. This study aims to simulate the catalytic hydrogenation of nitrobenzene in gas-liquid Taylor flow by combining interface-resolving numerical simulations of two-phase flow and mass transfer by a volume-of-fluid method with detailed modeling of the heterogeneous chemical reaction by software package DETCHEMTM. Practically relevant physical properties are utilized for hydrodynamic and mass transfer simulations in combination with a preliminary reaction mechanism based on density functional theory. Simulations of mass transfer are conducted using a predetermined velocity field and Taylor bubble shape. At the beginning of the simulation when liquid nitrobenzene is not saturated by hydrogen, axial profiles of surface species concentrations and reaction rates show local variations. As hydrogen dissolves in nitrobenzene, the concentration profiles of surface species at the wall become uniform, eventually reaching an equilibrium state. Neglecting the local variation in a short initial period will allow further simplification of modeling surface reactions within a Taylor flow.
Enablers and Barriers to Interprofessional Work-Integrated Learning Placements: A Qualitative Study of Rural and Regional Allied Health Supervisors' Perceptions.

Work-integrated learning (WIL) is central to the delivery of high quality student learning that provides students with the knowledge, skills, attitudes and professional networks for successful careers. In rural and regional Australia WIL placements can be particularly challenging to source due to limited clinical supervision capacity. This article reports regional Allied Health clinical supervisors' perceptions of enablers and barriers to engaging with interprofessional student WIL. A phenomenology of practice framework was used to interpret the data, highlighting three key themes: introducing an interprofessional lens early; tapping into unique possibilities; and setting up for success, balancing challenges with opportunities. The study identified key elements that may contribute to successful Allied Health interprofessional WIL placements in rural and regional settings, including incorporating early student placement opportunities, using shared interprofessional supervision to foster the development of junior clinicians' supervisory skills, and ensuring clarity around the purpose and processes of each interprofessional placement.
Evaluation of white grain maize varieties for growth, yield and yield components

Maize (Zea mays L.) is one of the most commonly cultivated crop after rice in Nepal. The present study was done to evaluate and recommend the best performing white maize genotypes in mid hill region of Nepal. This study was conducted at research field of Kavre, Nepal during the rainy season of 2019. Five white maize genotypes were evaluated in randomized complete block design with four replications where Deuti used as standard check. Ear and plant height of plant, days to 50% silking and tasseling, count of leaf above and below main cob, total number of leaf, cob length, cob diameter, kernel rows per cob, kernels count per row, thousand kernels weight, shelling and sterility percentage, stay green and grain yield parameters were observed. Deuti and DMH-7314 had good stay green and husk cover rating. Plant height (282.6 cm) and ear height (162.4 cm) was more in HB-008. Number of kernels per row was more in HB-008 (36.5) and HB-007 (36.5) and thousand kernel weights was more in DMH-7314 (386.3 g) followed by Deuti (353.9 g). DMH-7314 was late in tasseling (86 days) and silking (89 days) but shelling percentage was lowest in DMH-7314 (70.8) than other varieties. Analysis of variance reveled that genotype HB-008 (9.70 t/ha) as compared to standard check Deuti (7.80 t/ha). Thus genotype HB-008 perform better in mid hill region of Kavre, Nepal.
Experimental Study of Erosion Wear in a Centrifugal Slurry Pump Using Coriolis Wear Test Rig

The erosion wear in slurry pumps has been identified as a major problem during transportation of slurry as it affects the equipment performance and reduces its reliability and operation life. To simulate the erosion mechanism in slurry equipments mainly in casing and impeller, the Coriolis erosion test rig on the lines proposed by Pagalthivarthi and Helmly (1992) has been suitably modified and fabricated to undertake a comprehensive study on different materials. In the present experimental study, systematic experiments have been conducted on brass and mild steel specimen to establish the effect of solid particle size, solid concentration and rotational speed on wear. Slurries of fly ash (FA) and mixtures of fly ash (FA) and bottom ash (BA) in the ratio 4:1 and 3:2 have been used at different concentrations in the range of 20 to 65% (by weight). The test results obtained in terms of weight loss have shown that wear has a strong dependence on size of the solid particles and rotational speed where as its variation with solid concentration is close to linear.
Factors Associated with Alcohol Consumption Among Youth Men, Ethiopian 2016 Demographic Health Survey.

Background: Alcohol consumption is a global issue, both developed and underdeveloped countries' health trouble. Specifically in Ethiopia, youth men 15-24 years of age are engaged in psychoactive substances mainly alcohols. Alcoholic person has other concomitant mental illness the discord of school, unemployment and being low socio-economic status.Methods: A cross-sectional study using the 2016 Ethiopia Demographic and Health Survey (EDHS) data set was applied. The samples were selected using a two-stage stratified cluster sampling technique. The data were analyzed with SPSS version 20. Multivariate logistic regression analysis was performed to identify factors associated with alcohol consumption by controlling confounders. An adjusted odds ratio with a 95 % confidence interval was considered to declare a statistically significant association.Results: The present study comprised of 4486 weight samples of youth men. The prevalence of alcohol consumption among youth men in this study was 39.3 %. Men aged 15-19 (AOR=1.27 (95% CI =1.01-1.60), being unemployed (AOR=1.62 (95% CI=1.27-2.07), don’t have awareness about HIV/AIDS (AOR=4.70 (95%=2.44-9.01),being married (AOD 0.58(0.39-0.85) and poorer youth men (AOD =1.75(95%CI=1.21-2.54) ,being orthodox (AOR=5.12(95%CI =2.47-10.64), protestant (AOR=0.42(95% CI =0.20- 0.87)Muslim (AOR=0.07(95% CI=0.03-0.16) religious followers were significantly associated with alcohol consumption.Conclusion: Alcohol consumption among youth men was relatively high when we compared with other countries study. Strengthening the awareness of HIV/AIDS, change alcohol drinking experience on religious ceremonies especially in orthodox, organizes the youth and job creation is suggested to avert alcohol consumption trajectory.
Overweight/obesity in young adulthood interacts with aspects of EBV infection in MS etiology

Objective Because obesity affects the cellular immune response to infections, we aimed to investigate whether high body mass index (BMI) in young adulthood and high Epstein-Barr nuclear antigen 1 (EBNA-1) antibody levels interact with regard to MS risk. We also aimed at exploring potential 3-way interactions between BMI at age 20 years, aspects of Epstein-Barr virus (EBV) infection (high EBNA-1 antibody levels and infectious mononucleosis [IM] history, respectively) and the human leukocyte antigen (HLA)-DRB1*15:01 allele. Methods Using Swedish population-based case-control studies (5,460 cases and 7,275 controls), we assessed MS risk in relation to interactions between overweight/obesity at age 20 years, IM history, EBNA-1 levels, and HLA-DRB1*15:01 status by calculating ORs with 95% CIs using logistic regression. Potential interactions were evaluated on the additive scale. Results Overweight/obesity, compared with normal weight, interacted significantly with high (>50th percentile) EBNA-1 antibody levels (attributable proportion due to interaction 0.2, 95% CI 0.1–0.4). The strength of the interaction increased with higher category of EBNA-1 antibody levels. Furthermore, 3-way interactions were present between HLA-DRB1*15:01, overweight/obesity at age 20 years, and each aspect of EBV infection. Conclusions With regard to MS risk, overweight/obesity in young adulthood acts synergistically with both aspects of EBV infection, predominantly among those with a genetic susceptibility to the disease. The obese state both induces a chronic immune-mediated inflammation and affects the cellular immune response to infections, which may contribute to explain our findings.
Surface‐Wave Attenuation From Seismic Ambient Noise: Numerical Validation and Application

We evaluate, by numerical tests, whether surface‐wave attenuation can be determined from ambient‐noise data. We generate synthetic recordings of numerically simulated ambient seismic noise in several experimental setups, characterized by different source distributions and different values of attenuation coefficient. We use them to verify that the source spectrum can be reconstructed from ambient recordings (provided that the density of sources and the attenuation coefficient are known) and that true attenuation can be retrieved from normalized cross correlations of synthetic signals. We then apply the so validated method to real continuous recordings from 33 broadband receivers distributed within the Colorado Plateau and Great Basin. A preliminary analysis of the signal‐to‐noise ratio as a function of azimuth reveals a SW‐NE preferential directionality of the noise sources within the secondary microseism band (6–8 s), consistent with previous studies. By nonlinear inversion of noise data we find the attenuation coefficient in the area of interest to range from ∼ 1 × 10−5 m−1 at 0.3 Hz to ∼ 4.5 × 10−7 m−1 at 0.065 Hz, and confirm the statistical robustness of this estimate by means of a bootstrap analysis. The result is compatible with previous observations based on both earthquake‐generated and ambient Rayleigh waves. In this regard, the method proves to be promising in accurately quantifying surface‐wave attenuation at relatively high frequencies.
Understanding the drivers and motivations of farm diversification: Evidence from Northern Ireland using a mixed methods approach

Farmers are increasingly required to become more productive and innovative to ensure effective management of farm resources and to improve their livelihoods. Farm diversification has been identified as a viable strategy that can be adopted by farm businesses to achieve these objectives in order to reduce their reliance on agricultural production as the main source of household income. In this study, we employ a mixed methods approach to analyse the factors influencing farm diversification and diversification strategies in Northern Ireland. The challenges of setting up a farm diversification enterprise were also explored. Data collection and analysis were undertaken by combining both quantitative and qualitative approaches in a two-stage process using primary data obtained from a survey of farm businesses and interviews with key stakeholders involved in the Northern Ireland agricultural sector. The study results show that the primary motivating factor in pursuing farm-level diversification is the need to generate additional income. The analysis has shown that farm level diversification has the capacity to contribute to both the sustainability of family farms and the wider rural economy. The study results support the need for governments to explore the development of policy measures to support diversification at farm level.
Three-dimensional electron diffraction for porous crystalline materials: structural determination and beyond

Porous crystalline materials such as zeolites, metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) have attracted great interest due to their well-defined pore structures in molecular dimensions. Knowing the atomic structures of porous materials is crucial for understanding their properties and exploring their applications. Many porous materials are synthesized as polycrystalline powders, which are too small for structure determination by X-ray diffraction. Three-dimensional electron diffraction (3DED) has been developed for studying such materials. In this Minireview, we summarize the recent developments of 3DED methods and demonstrate how 3DED revolutionized structural analysis of zeolites, MOFs, and COFs. Zeolites and MOFs whose structures remained unknown for decades could be solved. New approaches for design and targeted synthesis of novel zeolites could be developed. Moreover, we discuss the advances of structural analysis by 3DED in revealing the unique structural features and properties, such as heteroatom distributions, mixed-metal frameworks, structural flexibility, guest–host interactions, and structure transformation.
PTPN6 promotes chemosensitivity of colorectal cancer cells via inhibiting the SP1/MAPK signalling pathway

The abnormal expression of protein tyrosine phosphatase nonreceptor type 6 (PTPN6) has been proved to be associated with the progression of colorectal cancer. However, its role in chemosensitivity and related molecular mechanism have not been clarified. It has been reported that PTPN6 was down‐regulated in colorectal cancer cells compared with the normal colorectal cells. To evaluate the effects of PTPN6 on the proliferation and survival of colorectal cancer cells, PTPN6 was overexpressed in colorectal cancer cells in the present study. We found that cell proliferation and viability were both decreased after overexpression of PTPN6. The IC50 of 5‐Fu against colorectal cells was also declined in PTPN6 transfected cells. And further, we verified that PTPN6 could down‐regulate the expression of P‐gp and MRP‐1. Moreover, SP1 was the target protein of PTPN6 predicated by ChIPBase software and confirmed through Co‐immunoprecipitation assay and it was negatively regulated by PTPN6. To further verify the effect of SP1 on chemoresistance, SP1 was overexpressed. SP1 overexpression enhanced the drug‐resistance to 5‐Fu and abrogated the effects of PTPN6 upregulation on 5‐Fu resistance. All the above changes were associated with the down‐regulation of proteins related to MAPK signalling pathway, such as phosphorylation of extracellular regulated protein kinases (ERK) and p38. In summary, PTPN6 promoted chemosensitivity of colorectal cancer cells by targeting SP1 and inhibiting the activation of MAPK signalling pathway.