Miracle-dz/UniFAR-FTUs huggingface dataset:
Socioeconomic, Clinical, and Laboratory Parameters Differentiating Pediatric Patients With MOG Antibody–Associated Disease and Multiple Sclerosis

Studies indicate differences in the clinical phenotypes and neuroimaging of children with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) compared to multiple sclerosis; however, there are limited data assessing the socioeconomic and paraclinical differences between these distinct disorders. This retrospective study identified patients aged <18 years at time of diagnosis with MOGAD or multiple sclerosis. Demographics, birth history, socioeconomic factors (insurance type, median income, parental education level), and paraclinical features (clinical manifestations, laboratory evaluation) were recorded for eligible participants. Seventy-eight patients (28 MOGAD, 50 multiple sclerosis) met inclusion criteria. Mothers of MOGAD children were more likely to have attended college compared to the mothers of children with multiple sclerosis (80% vs 49%; P = .02). Though MOGAD patients had greater rates of day care attendance (81% vs 57%), lower rates of birth complications (7% vs 21%), and higher rates of being breastfed (65% vs 46%), these findings did not meet predefined statistical significance. Clinically, children with MOGAD exhibited a lower body mass index percentile at presentation (58th ± 27th percentile vs 83rd ± 20th percentile; P = .0001) and were younger (7.6 ± 4.1 vs 14.8 ± 1.6 years; P < .0001) and more likely to exhibit an infectious prodrome (57% vs 10%; P < .0001). MOGAD patients were less likely to have evidence of remote Epstein-Barr virus infection (29% vs 100%; P < .0001) and less likely to have ≥3 unique oligoclonal bands in the cerebrospinal fluid (5% vs 87%; P < .001). Compared with multiple sclerosis, children with MOGAD exhibit lower body mass index percentiles at presentation, are more likely to have mothers with higher education levels, and are less likely to have had prior Epstein-Barr virus infection. Our data confirm that MOGAD patients are younger, more likely to exhibit infectious prodrome, and are less likely to exhibit intrathecal synthesis of oligoclonal bands. These features provide new insights into the differentiating pathobiology of MOGAD and may be helpful in differentiating these children from multiple sclerosis early in the diagnostic evaluation.
Attitude towards patients with psychiatric illness among undergraduate medical students at Government Medical College: A cross-sectional study

Background: People with mental illnesses commonly experience stigma, discrimination, and prejudice from the general public and medical professionals around the world. Numerous research has looked into the unfavourable perceptions that medical students have of those who suffer from mental illness. Objective: The objective was to study the attitude of undergraduate medical students towards patients with psychiatric illnesses. Materials and Methods: A cross-sectional study was carried out among undergraduate medical students who were exposed (n = 69) to 2-week psychiatry posting and attended lectures and those who were not exposed (n = 163) to psychiatry training using self-reported Attitude Scale for Mental Illness (ASMI) questionnaire via Google form distributed among medical students. Results: The findings indicate there is no change in attitude toward the patient with psychiatric illness after exposure to psychiatry training among medical students. However, urban residence and female gender were the factors found to be influencing students' attitudes towards patients with psychiatric illnesses. Conclusions: There was no change in attitude towards patients with psychiatric illness after psychiatry exposure. Students belonging to urban domicile and female students showed more sympathetic attitudes toward those with mental illnesses.
Structural and Scintillation Properties of Ce3+:Gd3Al3Ga2O12 Translucent Ceramics Prepared by One-Step Sintering

Cerium-doped gadolinium aluminum gallium garnet (Ce3+:Gd3Al3Ga2O12, Ce3+:GAGG) ceramic is a promising scintillation material. In this study, Ce3+:Gd3Al3Ga2O12 scintillation ceramics were prepared by the one-step sintering of commercially available Gd2O3, Al2O3, Ga2O3, and CeO2 powders in a flowing oxygen atmosphere at 1600 °C by solid-phase reaction sintering. For all the Ce3+:Gd3Al3Ga2O12 ceramic samples doped with different amounts of Ce3+ doping, dense ceramics were obtained. The structure, photoluminescence, and scintillation properties of the Ce3+:Gd3Al3Ga2O12 ceramics have been investigated. The average grain size of samples sintered at 1600 °C is about 2 μm. The X-ray excitation luminescence peak is around 560 nm, which is consistent with that of Ce3+:Gd3Al3Ga2O12 single crystals, matching well with the computed tomography X-ray detector’s response sensitivity. The light yield is higher compared to the standard reference sample—lutetium yttrium orthosilicate single crystal.
Analyzing International Business and Financial Cycles using Multi-Level Factor Models: A Comparison of Alternative Approaches

This paper compares alternative estimation procedures for multi-level factor models which imply blocks of zero restrictions on the associated matrix of factor loadings. We suggest a sequential least squares algorithm for minimizing the total sum of squared residuals and a two-step approach based on canonical correlations that are much simpler and faster than Bayesian approaches previously employed in the literature. An additional advantage is that our approaches can be used to estimate more complex multi-level factor structures where the number of levels is greater than two. Monte Carlo simulations suggest that the estimators perform well in typical sample sizes encountered in the factor analysis of macroeconomic data sets. We apply the methodologies to study international comovements of business and financial cycles.
Myd88 Signaling Is Involved in the Inflammatory Response in LPS-Induced Mouse Epididymitis and Bone-Marrow-Derived Dendritic Cells

Epididymitis is an epididymal inflammation that may lead to male infertility. Dendritic cells (DCs) and myeloid differentiation primary response gene 88 (Myd88) were associated with epididymitis in rodents. However, the functions of Myd88 on epididymal DCs remain unclear. This study investigated the role of Myd88 in DCs for epididymitis. The Myd88 signaling pathway, phenotypes of DC subsets, and cytokines were investigated in lipopolysaccharide (LPS)-induced epididymitis in mice. CRISPR-Cas9 was used to knockout Myd88 in bone-marrow-derived dendritic cells (BMDCs) and immortalized mouse epididymal (DC2) cell line. In the vivo experiments, levels of the proinflammatory cytokines IL-1α, IL-6, IL-17A, TNF-α, IL-1β, MCP-1, and GM-CSF, mRNA for MyD88 related genes, and the percentages of monocyte-derived DCs (Mo-DCs) were significantly elevated in mice with epididymitis. In the vitro experiments, LPS significantly promoted the apoptosis of BMDCs. In addition, the concentration of inflammatory cytokines in BMDCs and DC2s were increased in the LPS group, while decreasing after the knockout of Myd88. These findings indicate that Myd88 on DCs is involved in the inflammation of epididymitis in mice, which may be a potential target for better strategies regarding the treatment of immunological male infertility.
Acoustics in the Klebanoff-Saric Wind Tunnel: Background Identification, Forcing, and Active Control

Acoustics in the Klebanoff–Saric Wind Tunnel: Background Identification, Forcing, and Active Control. (May 2012) Matthew Scott Kuester, B.S., Texas A&M University Chair of Advisory Committee: Dr. Edward White Low disturbance wind tunnels, such as the Klebanoff–Saric Wind Tunnel (KSWT), offer an ideal environment to study boundary layer transition. In particular, the leading-edge receptivity of sound can be measured by creating acoustic disturbances that interact with the leading edge of a model to create Tollmien–Schlichting waves. The magnitude and composition (sound, turbulence) of the background disturbances can affect these experiments, so the background disturbances should be minimized and documented thoroughly. The purpose of this thesis is to document the background acoustic signature of the KSWT and describe infrastructure upgrades for acoustic receptivity experiments. The measurements presented in this thesis will support future receptivity measurements in the KSWT. Microphone measurements revealed several important acoustic features in the tunnel. Cross correlations showed that two sources of low-frequency unsteadiness (the extended diffuser and corner two) create large pressure fluctuations that dominate the pressure spectrum. Directional separation of waves in the test section revealed that motor
Identification and validation of a novel prognostic circadian rhythm-related gene signature for stomach adenocarcinoma

ABSTRACT Circadian rhythm genes were reported to be strongly associated with the development and prognosis of circadian rhythm disorders related to stomach adenocarcinoma (STAD), which is one of the most prevalent cancers. This study aimed to identify a circadian rhythm-related gene signature that could help predict STAD outcome. Using bioinformatics analysis approaches, 105 genes were examined in 350 patients with STAD. Overall, six hub-type circadian rhythm-associated genes (GNA11, PER1, SOX14, EZH2, MAGED1, and NR1D1) were identified using univariate and multivariate Cox regression analyses. These genes were then used to build a genetic predictive model, which was further validated using a publicly available dataset (GSE26899). Overall, genes associated with the circadian rhythm were found to be substantially correlated with the characteristics of the STAD patients (grade, sex, and M stage). In addition, the circadian rhythm-related gene signature was significantly associated with the MAPK and Notch signaling pathways, which are known risk factors for poorer STAD outcome. Taken together, these findings suggest that the herein proposed prognostic model based on six circadian rhythm-associated genes may have predictive value and potential application for clinical decision-making and for personalized treatment of STAD.
Mitochondria-Stimulating and Antioxidant Effects of Slovak Propolis Varieties on Bovine Spermatozoa

Propolis is a natural honeybee product, which is known for its beneficial pharmacological effects and use in traditional medicine. This study aspired to investigate the chemical and antioxidant properties of five propolis specimens, followed by the analysis of their in vitro impact on bovine spermatozoa vitality and oxidative profile. Semen samples from 10 breeding bulls were incubated in the absence or presence of 50 µg/mL propolis extracts, and selected sperm quality parameters including motility, mitochondrial activity, cAMP concentration, NAD+/NADH ratio, reactive oxygen species (ROS) and superoxide production were assessed at 2 h and 24 h. Sperm motion behavior and mitochondrial function were stabilized particularly in the presence of propolis collected from Hrabské and Litpovský Hrádok, Slovakia. At the same time, all propolis specimens acted as significant ROS quenchers and stabilized the oxidative milieu of the sperm cultures. Our data suggest that propolis may stabilize the mitochondrial function of spermatozoa while preventing excessive oxidative insults, thereby showing the potential to sustain the sperm motility of extended semen.
The decay of global solutions of a semilinear heat equation

We are interested in the time decay estimates of global solutions of the semilinear parabolic equation $u_t= \Delta u+|u|^{p-1}u$ in $\R^N\times\R^+$, where $p>1$. We find several new sufficient and/or necessary conditions guaranteeing that the solution for $t$ large behaves like the solution of the linear heat equation or has the self-similar decay. We are particularly interested in the behaviour of threshold solutions lying on the borderline between global existence and blow-up.
The Behaviour of Sheep around a Natural Waterway and Impact on Water Quality during Winter in New Zealand

Simple Summary The impacts of extensively managed sheep on the natural environment has received little attention in comparison to beef and dairy cattle in New Zealand. In particular, there is a paucity of information on the interaction of sheep with natural waterways and their impact on water quality. The current study was designed to determine the behaviour of sheep on a hill country paddock, which was transected by a natural waterway, and assessed measures of water quality during winter conditions. The study also investigated sheep behaviour and impact on the water quality of the waterway when they had access to a reticulated water trough. Observations of behaviour showed that sheep spent little time near the waterway compared to other areas of the paddock. In addition, access to a water trough had no effect on ewe time spent grazing, walking, resting, and drinking. Ewes had minimal interaction with the waterway. Hence, under the current conditions of the study, sheep had little impact on the waterway. This may have been due to the high moisture content of pasture during winter; thus, the sheep were not required to interact with the waterway. Abstract Access of livestock, such as cattle, to waterways has been shown to be a cause of poor water quality due to pugging damage and excretion entering the water. In New Zealand, regulations require that cattle, deer, and pigs are excluded from accessing waterways, but there are no such requirements for sheep. The current study utilised 24 h video cameras, global positioning system units, and triaxial accelerometers to observe the interaction of Romney ewes (n = 40) with a natural waterway. Ewes were either restricted (week 1) or given access to a reticulated water trough (week 2). Proximity data showed that ewes spent more time within 3 m of the waterway when the trough was unrestricted than when restricted (14.1 ± 5.7 and 10.8 ± 5.1 min/ewe/day, respectively; p < 0.05). Ewes travelled shorter distances on the steeper areas of paddock than flatter areas. Similarly, ewes showed a spatial preference for the flat and low sloped areas of the paddock. Concentrations of suspended sediment and total phosphorus were higher during access to a reticulated water trough which coincided with the week with more rainy days. Phosphorus and E. coli concentrations in the stream water samples were the above recommended Australian and New Zealand Environment and Conservation Council water quality guidelines, especially after rainy days, but did not appear to be directly related to sheep activity. Overall, the results suggest that during winter, ewes interacted very little with the waterway and were thus unlikely to influence the levels of nutrient and pathogens in the waterway.
A clinico-epidemiological profile, coinfections and outcome of patients with Influenza Like Illnesses (ILI) presenting to the emergency department during the COVID-19 pandemic

Background: During the COVID-19 pandemic, many patients presented to the emergency department (ED) with features of Influenza-like illnesses (ILI) and with other atypical presentations. This study was done to determine the etiology, co-infections, and clinical profile of patients with ILI. Methods: This prospective observational study included all patients presenting to the ED with fever and/or cough, breathing difficulty, sore throat, myalgia, gastrointestinal complaints (abdominal pain/vomiting/diarrhea), loss of taste and altered sensorium or asymptomatic patients who resided in or travelled from containment zones, or those who had contact with COVID-19 positive patients during the first wave of the pandemic between April and August 2020. Respiratory virus screening was done on a subset of COVID-19 patients to determine co-infection. Results: During the study period, we recruited 1462 patients with ILI and 857 patients with the non-ILI presentation of confirmed COVID-19 infection. The mean age group of our patient population was 51.4 (SD: 14.9) years with a male predominance (n-1593; 68.7%). The average duration of symptoms was 4.1 (SD: 2.9) days. A sub-analysis to determine an alternate viral etiology was done in 293 (16.4%) ILI patients, where 54 (19.4%) patients had COVID 19 and co-infection with other viruses, of which Adenovirus (n-39; 14.0%) was the most common. The most common symptoms in the ILI-COVID-19 positive group (other than fever and/or cough and/or breathing difficulty) were loss of taste (n-385; 26.3%) and diarrhea (n- 123; 8.4%). Respiratory rate (27.5 (SD: 8.1)/minute: p-value < 0.001) and oxygen saturation (92.1% (SD: 11.2) on room air; p-value < 0.001) in the ILI group were statistically significant. Age more than 60 years (adjusted odds ratio (OR): 4.826 (3.348-6.956); p-value: <0.001), sequential organ function assessment score more than or equal to four (adjusted OR: 5.619 (3.526-8.957); p-value: <0.001), and WHO critical severity score (Adjusted OR: 13.812 (9.656-19.756); p-value: <0.001) were independent predictors of mortality. Conclusion: COVID-19 patients were more likely to present with ILI than atypical features. Co-infection with Adenovirus was most common. Age more than 60 years, SOFA score more than or equal to four and WHO critical severity score were independent predictors of mortality.
Connections Between Optimal Stopping and Singular Stochastic Control II. Reflected Follower Problems

The stochastic control problem of following a Brownian path by a process of bounded variation, and subject to a reflecting barrier at the origin (reflected follower), is reduced to a question of optimal stopping with absorption. Direct probabilistic arguments are used to establish the equivalence of the two problems under suitable conditions on the cost functions.
Efficacy of aerobic training and resistance training combined with external diaphragm pacing in patients with chronic obstructive pulmonary disease: A randomized controlled study

Objective To evaluate the efficacy of aerobic training, resistance training combined with external diaphragm pacing in patients with chronic obstructive pulmonary disease. Design Randomized controlled trial. Setting The Fourth Rehabilitation Hospital of Shanghai, China. Participants 82 (67.0 ± 6.5 years, 59.8% male) patients with stable chronic obstructive pulmonary disease were randomized to intervention group 1 (n = 27), intervention group 2 (n = 28), and control group (n = 27). Intervention Intervention group 1 received aerobic and resistance training, while intervention group 2 received additional external diaphragm pacing. Control group received aerobic training only. Main measures 1-year follow-up of physical activity, body composition, respiratory function and diaphragm function. Results Intervention groups 1 and 2 showed statistically improvements in the difference value compared with control group in terms of 6-min walk distance (−95.28 ± 20.09 and −101.92 ± 34.91 vs −63.58 ± 23.38), forced expiratory volume in 1 s (−0.042 ± 0.027 and −0.130 ± 0.050 vs −0.005 ± 0.068), fat-free mass (−2.11 ± 3.74 and −3.82 ± 3.74vs 0.28 ± 1.49) and chronic obstructive pulmonary disease assessment test value (2.16 ± 0.85 and 2.38 ± 1.02 vs 1.50 ± 0.93). Intervention group 2 showed significant difference in arterial oxygen pressure (−4.46 ± 3.22 vs −1.92 ± 3.45), diaphragm excursion during deep breaths (−0.82 ± 0.74 vs −0.38 ± 0.29), and diaphragm thickness fraction (−8.77 ± 3.22 vs −4.88 ± 2.69) compared with control group. Conclusion The combination of aerobic training, resistance training, and external diaphragm pacing obtained significant improvements in physical activity, respiratory function, body composition, arterial oxygen pressure, and diaphragm function in patients with chronic obstructive pulmonary disease. Trial registration ChiCTR1800020257, www.chictr. org.cn/index.aspx
Global negative effects of drought on instream invertebrate communities

Abstract Global climate change has led to more frequent and severe droughts, which can negatively affect instream invertebrate communities, but we lack a perspective on the global patterns and drivers of such drought effects. Here, using meta-analysis, we synthesized 997 paired observations extracted from 94 peer-reviewed publications to assess how drought affects the biomass, density, taxonomic richness, and diversity (Shannon–Wiener, Simpson, and Pielou indices) of instream invertebrates at a global scale. We found that (i) drought significantly decreased instream invertebrate density and taxonomic richness by an average of 4.9 and 5.0%, respectively, had marginal negative effects on Shannon–Wiener index, but did not affect biomass, Simpson index or Pielou index; (ii) the effects of drought on instream invertebrate biomass, density, and diversity were not affected by taxonomic level, indicating the robustness of our results; and (iii) stream water physiochemical characteristics such as water flow velocity, pH, conductivity, discharge, total nitrogen concentration, and chlorophyll-a concentration were important moderator variables of drought effects on instream invertebrate communities. Overall, our results clearly showed the global patterns and driving factors of drought effects on instream invertebrate biomass, density, richness, and diversity, which helps scientists better understand the responses of instream invertebrate communities under ongoing global climate change.
Modelling of Advanced Dependencies Between the Start and the End of Activities in Business Processes

: The control-flow of a business process (BP) defines the allowed execution orders of its activities. Until now, only whole activities can be used to define such orders. This shall be extended: Additional execution orders are enabled by allowing to use the start and the end events of activities at control flow modelling. For example, defining that the end of Act. A must happen before the end of Act. B, increases the flexibility since Act. B can be started earlier as with a classic sequence edge. This paper presents corresponding examples from practice and derives the resulting requirements for BP modelling. Furthermore, possibilities for a BP modelling tool are discussed, to visualize such dependencies graphically.
Impact of Post-Operative Infection after CABG on Long-Term Survival

Coronary artery bypass grafting (CABG) is one of the most common cardiac surgical procedures. It is commonly known that post-operative infection has a negative impact on the patient’s short-term treatment outcomes and long-term prognosis. The aim of the present study was to assess the impact of perioperative infection on 5-year and 10-year survival in patients undergoing elective on-pump CABG surgery. The present prospective observational study was carried out between 1 July 2010 and 31 August 2012 among patients undergoing cardiac surgery at our centre. Infections were identified according to the ECDC definitions. We initially assessed the incidence of infection and its relationship with the parameters analysed. We then analysed the effect of particular parameters, including infection, on 5-year and 10-year survival after surgery. We also analysed the impact of particular types of infection on the risk of death within the period analysed. The significant risk factors for reduced survival were age (HR 1.05, CI 1.02–1.07), peripheral artery disease (HR 1.99, CI 1.28–3.10), reduced LVEF after surgery (HR 0.96, CI 0.94–0.99), post-operative myocardial infarction (HR 1.45, CI 1.05–2.02) and infection (HR 3.10, CI 2.20–4.28). We found a strong relationship between post-operative infections and 5-year and 10-year mortality in patients undergoing CABG. Pneumonia and BSI were the only types of infection that were found to have a significant impact on increased long-term mortality after CABG surgery.