Miracle-dz/UniFAR-FTUs huggingface dataset:
Retrograde intrarenal surgery: laser showdown (Ho:YAG vs thulium fiber laser)

Purpose of review Retrograde intrarenal surgery (RIRS) has always been recommended for large stones > 20 mm, using the Ho:YAG laser. The introduction of a new technology in the urological market, the thulium fiber laser (TFL) has revolutionized the endourology world because of its characteristics and significantly shorter laser-on time (LOT) and operative time, without scarifying the champ vision. The aim of this review is to evaluate the most relevant findings of the last 2 years of each laser technology, confronting Ho:YAG vs TFL, analyzing who is more suitable for performing an efficient RIRS. Recent findings Five full clinical trials using TFL for RIRS were found. Median LOT was between 2.8 and 34 min. All stones were similar in terms of stone volume, >500 mm3, and stone density, > 800 HU. Low complication rate, mostly Clavien-Dindo grade I and II and not related to the laser itself. One clinical trial only analyzed the efficacy of TFL for > 20 mm renal stones. Summary Based on this review, TFL performs a more efficient RIRS than the Ho:YAG laser with similar safety.
A Comparative Study of Users versus Non-Users' Behavioral Intention towards M-Banking Apps' Adoption

The banking sector has been considered as one of the primary adopters of Information and Communications Technologies. Especially during the last years, they have invested a lot into the digital transformation of their business process. Concerning their retail customers, banks realized very early the great potential abilities to provide value added self-services functions via mobile devices, mainly smartphones to them; thus, they have invested a lot into m-banking apps’ functionality. Furthermore, the COVID-19 pandemic has brought out different ways for financial transactions and even more mobile users have taken advantage of m-banking app services. Thus, the purpose of this empirical paper is to investigate the determinants that impact individuals on adopting or not m-banking apps. Specifically, it examines two groups of individuals, users (adopters) and non-users (non-adopters) of m-banking apps, and aims to reveal if there are differences and similarities between the factors that impact them on adopting or not this type of m-banking services. To our knowledge, this is the second scientific attempt where these two groups of individuals have been compared on this topic. The paper proposes a comprehensive conceptual model by extending Venkatech’s et al. (2003) Unified Theory of Acceptance and Use of Technology (UTAUT) with ICT facilitators (i.e., reward and security) and ICT inhibitors (i.e., risk and anxiety), as well as the recommendation factor. However, this study intends to fill the research gap by investigating and proving for the first time the impact of social influence, reward and anxiety factors on behavioral intention, the relationship between risk and anxiety and the impact of behavioral intention on recommendation via the application of Confirmatory Factor Analysis and Structural Equation Modeling (SEM) statistical techniques. The results reveal a number of differences regarding the factors that impact or not these two groups towards m-banking app adoption; thus, it provides new insights regarding m-banking app adoption in a slightly examined scientific field. Thus, the study intends to assist the banking sector in better understanding their customers with the aim to formulate and apply customized m-business strategies and increase not only the adoption of m-banking apps but also the level of their further use.
Survival of the Fittest? Examining Lapsing Behaviour in the Context of Elderly People and the Use of Physical Activity Tracker Applications

Physical activity (PA) tracker applications have been proposed as one potential solution to the increasingly prevalent physical inactivity problem among elderly people, but their long-term potential is limited by the frequent lapses in their use. In this study, our ob-jective is to promote the understanding of the lapsing behaviour of PA tracker applications among elderly people. More specifically, we are interested in how gender, age, and household type as well as initial PA level and technology readiness (TR) affect the risk of lapsing. As the data for the study, we use actual PA tracker application usage data as well as survey data, which were both collected in our ongoing research program and are analysed by using survival analysis. We find lapsing behaviour to be affected mainly by initial PA level as well as to some degree by TR and gender but not by age and household type.
Algorithms for computerised monitoring the performance of DCP network

India Meteorological Department (IMD) has been operating a network of one hundred Automatic Weather Stations called Data Collection Paltform (DCP) since 1986. All these stations are unmanned and there is no way to know the working status of DCP equipment except to extract such Information from the data transmitted by them. Hence suitable algorithms were developed to evaluate the working status of various sub-systems of DCP stations by analysing the data received from them, which is essential for their effective and efficient maintenance. The concept used in developing these algorithms is described here.
The demand for gratitude as a restraint on the use of child labor: A hypothesis

Abstract We study a parent's demand for gratitude from his child. We view this demand as an intervening variable between the parent's earnings and the incidence of child labor. The demand for gratitude arises from the desire of a parent to receive care and support from his child late in life, while the inclination of the child to provide this support during his adulthood is determined by how the child was treated by his parent during childhood. Specifically, we model the child's gratitude as an inverse function of the intensity of his labor in childhood. We show that when we keep the child's (imputed) wage constant, the intensity of child labor decreases with the parent's earnings. However, when we make the child's (imputed) wage a function of the parent's earnings, then the outcome can be different. With the help of a numerical example, we show that the pattern of child labor related to the parent's earnings can be U-shaped.
Manualized group cognitive behavioral therapy for social anxiety in first-episode psychosis: a randomized controlled trial

Abstract Background Social anxiety (SA), a prevalent comorbid condition in psychotic disorders with a negative impact on functioning, requires adequate intervention relatively early. Using a randomized controlled trial, we tested the efficacy of a group cognitive-behavioral therapy intervention for SA (CBT-SA) that we developed for youth who experienced the first episode of psychosis (FEP). For our primary outcome, we hypothesized that compared to the active control of group cognitive remediation (CR), the CBT-SA group would show a reduction in SA that would be maintained at 3- and 6-month follow-ups. For secondary outcomes, it was hypothesized that the CBT-SA group would show a reduction of positive and negative symptoms and improvements in recovery and functioning. Method Ninety-six patients with an FEP and SA, recruited from five different FEP programs in the Montreal area, were randomized to 13 weekly group sessions of either CBT-SA or CR intervention. Results Linear mixed models revealed that multiple measures of SA significantly reduced over time, but with no significant group differences. Positive and negative symptoms, as well as functioning improved over time, with negative symptoms and functioning exhibiting a greater reduction in the CBT-SA group. Conclusions While SA decreased over time with both interventions, a positive effect of the CBT-SA intervention on measures of negative symptoms, functioning, and self-reported recovery at follow-up suggests that our intervention had a positive effect that extended beyond symptoms specific to SA. ClinicalTrials.gov identifier: NCT02294409.
A Tm4sf1-Marked Subpopulation of Endothelial Stem/Progenitor Cells Identified by Lung Single-Cell Omics of Pulmonary Arterial Hypertension

Rationale The identification and role of endothelial progenitor cells (EPCs) in pulmonary arterial hypertension (PAH) remains controversial. Single-cell omics analysis can shed light on EPCs and their potential contribution to PAH pathobiology. Objectives We aim to identify EPCs in rat lungs and assess their relevance to preclinical and human PAH. Methods Differential expression, gene set enrichment, cell-cell communication, and trajectory reconstruction analyses were performed on lung endothelial cells from single-cell RNA-seq of Sugen-hypoxia, monocrotaline, and control rats. Relevance to human PAH was assessed in multiple independent blood and lung transcriptomic datasets. Measurements and Main Results A subpopulation of endothelial cells (EA2) marked by Tm4sf1, a gene strongly implicated in cancer, harbored a distinct transcriptomic signature including Bmpr2 downregulation that was enriched for pathways such as inflammation and angiogenesis. Cell-to-cell communication networks specific to EA2 were activated in PAH such as CXCL12 signaling. Trajectory analysis demonstrated EA2 has a stem/progenitor cell phenotype. Analysis of independent datasets revealed Tm4sf1 is a marker for hematopoietic stem cells and is upregulated in PAH peripheral blood, particularly in patients with worse WHO functional class. EA2 signature genes including Procr and Sulf1 were found to be differentially regulated in the lungs of PAH patients and in PAH models in vitro, such as BMPR2 knockdown. Conclusions Our study uncovered a novel Tm4sf1-marked stem/progenitor subpopulation of rat lung endothelial cells and demonstrated its relevance to preclinical and human PAH. Future experimental studies are warranted to further elucidate the pathogenic role and therapeutic potential of targeting EA2 and Tm4sf1 in PAH.
Aquatic Therapy for Persons with Neuromuscular Diseases – A Scoping Review

Background: Aquatic exercise is among the most common physical activity modalities performed by people with disabilities. Objective: The present paper reviews currently-available research on aquatic therapy (AT) for persons with neuromuscular diseases (NMD). Methods: A scoping review of the existing literature was conducted on PubMed, Embase, Medline, Scopus, Web of Science, SPORTdiscus, CINAHL and Lilacs from the earliest date available until October 2020. It follows the methodological framework for conducting a scoping review proposed by the Joanna Briggs Institute. Results: A total of 28 articles were analyzed and the study parameters grouped by the topography of NMD; most of the studies (n = 16) addressed myopathies. A considerable increase in the number of studies was found over time, and heterogeneity was identified across and within AT interventions for persons with NMD; hence, to allow more effective interpretation of study results, there is a need to standardize the fundamental parameters and procedures for AT. Conclusions: This scoping review provides a comprehensive outline of available literature; the findings could serve as a starting point for clinical studies on the effects of AT on persons with NMD, and encourage a more coherent approach to their design.
A Hybrid Technique for Active SLAM Based on RPPO Model with Transfer Learning

The problem of exploration in unknown environments is still a great challenge for autonomous mobile robots due to the lack of a priori knowledge. Active Simultaneous Localization and Mapping (SLAM) is an effective method to realize obstacle avoidance and autonomous navigation. Traditional Active SLAM is usually complex to model and difficult to adapt automatically to new operating areas. This paper presents a novel Active SLAM algorithm based on Deep Reinforcement Learning (DRL). The Relational Proximal Policy Optimization (RPPO) model with deep separable convolution and data batch processing is used to predict the action strategy and generate the action plan through the acquired environment RGB images, so as to realize the autonomous collision free exploration of the environment. Meanwhile, Gmapping is applied to locate and map the environment. Then, based on Transfer Learning, Active SLAM algorithm is applied to complex unknown environments with various dynamic and static obstacles. Finally, we present several experiments to demonstrate the advantages and feasibility of the proposed Active SLAM algorithm.
Competitive Adsorption of Copper, Zinc, and Chromium from Wastewater Using Corn-Cob Ash: Optimization Approach

Corn Cob ash was used in competitive adsorption of copper, zinc, and chromium from wastewater. The central composite design; a sub-set of response surface methodology was used to optimize the adsorption of the heavy metals. The result of the statistical parameters showed the coefficient of determination (R2) of 1.000, 0.999, and 1.000 for copper, zinc, and chromium respectively. The optimal conditions obtained for adsorbent dosage, initial concentration, temperature, contact time, and particle size were 13.20 mg, 79.72 mg/l, 34.95 °C, 40.38 min, and 1400 µm, respectively with the desirability of 1.000. The predicted and the actual values of metal removal obtained were 69.41%, 76.37%, as well as 70.44%, 72.50%, 77.90 % and 71.00% for copper, zinc, and chromium respectively. The ressult indicated a good conformity between the model predicted values and the actual values, thus having small errors of 3.09%, 1.53 % and 0.56 % for copper, zinc, and chromium respectively.
ASF1B Serves as a Potential Therapeutic Target by Influencing Cell Cycle and Proliferation in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high morbidity and mortality. Therefore, it is very important to find potential biomarkers that can effectively predict the prognosis and progression of HCC. Recent studies have shown that anti-silencing function 1B (ASF1B) may be a new proliferative marker for tumor diagnosis and prognosis. However, the expression and function of ASF1B in hepatocellular carcinoma remain to be determined. In this study, integrated analysis of the Cancer Genome Atlas (TCGA), genotypic tissue expression (GTEx), and Gene Expression Omnibus (GEO) databases revealed that ASF1B was highly expressed in HCC. Kaplan-Meier survival curve showed that elevated ASF1B expression was associated with poor survival in patients with liver cancer. Correlation analysis of immune infiltration suggested that ASF1B expression was significantly correlated with immune cell infiltration in HCC patients. Gene set enrichment analysis (GSEA) indicated that ASF1B regulated the cell cycle, DNA Replication and oocyte meiosis signaling. Our experiments confirmed that ASF1B was highly expressed in HCC tissues and HCC cell lines. Silence of ASF1B inhibited hepatocellular carcinoma cell growth in vitro. Furthermore, ASF1B deficiency induced apoptosis and cell cycle arrest. Mechanistically, ASF1B knockdown reduced the expression of proliferating cell nuclear antigen (PCNA), cyclinB1, cyclinE2 and CDK9.Moreover, ASF1B interacted with CDK9 in HCC cells. Taken together, these results suggest that the oncogenic gene ASF1B could be a target for inhibiting hepatocellular carcinoma cell growth.
Defining a Supportive Organizational Context for IPC in Primary Care: A
 Mixed Methods Study

INTRODUCTION The purpose of this exploratory sequential mixed methods study was to explore organizational contextual factors important to successful interprofessional collaboration (IPC) among primary care teams. METHODS In Phase 1, a single embedded case study design was utilized to identify the organizational contextual factors most important to successful IPC. In Phase 2, a quantitative survey was administered to primary care team members in 10 organizations to objectively measure the relationship between contextual factors identified in Phase 1 and IPC. RESULTS In Phase 1, organizational contextual factors deemed most important included team structure and resources, including staff, time, and communication tools; supportive, patient-centered culture, including team member support and expectations for IPC as the way to provide the best care to patients; leadership, including organizational leadership support and provider leadership; and organizational structure and resources, including status as a federally qualified health center (FQHC) and academic facility. In Phase 2, statistically significant, positive relationships were found between IPC and team member support, provider leadership, team resources, clan culture, perceived organizational support, and patient-centered values. CONCLUSIONS The findings support the importance of organizational context for IPC and suggest that organizational culture and leadership hold particular importance for IPC success.
Does Seasonal Influenza Related Hospital Occupancy Surge Impact Hospital Staff Sickness Presenteeism and Productivity Costs?

Background—The workload of public hospital staff is heightened during seasonal influenza surges in hospitals serving densely populated cities. Such work environments may subject staff to increased risk of sickness presenteeism. Presenteeism is detrimental to nurses’ health and may lead to downstream productivity loss, resulting in financial costs for hospital organizations. Aims—This study aims to quantify how seasonal influenza hospital occupancy surge impacts nurses’ sickness presenteeism and related productivity costs in high-intensity inpatient metropolitan hospitals. Methods—Full-time nurses in three Hong Kong acute-care hospitals were surveyed. Generalized estimating equations (GEE) was applied to account for clustering in small number of hospitals. Results—A total of 71.3% of nurses reported two or more presenteeism events last year. A 6.8% increase in hospital inpatient occupancy rate was associated with an increase of 19% (1.19, 95% CI: 1.06–1.34) in nurse presenteeism. Presenteeism productivity loss costs between nurses working healthy (USD1983) and worked sick (USD 2008) were not significantly different, while sick leave costs were highest (USD 2703). Conclusion—Presenteeism prevalence is high amongst acute-care hospital nurses and workload increase during influenza flu surge significantly heightened nurse sickness presenteeism. Annual presenteeism productivity loss costs in this study of USD 24,096 were one of the highest reported worldwide. Productivity loss was also considerably high regardless of nurses’ health states, pointing towards other potential risk factors at play. When scheduling nurses to tackle flu surge, managers may want to consider impaired productivity due to staff presenteeism. Further longitudinal research is essential in identifying management modifiable risk factors that impact nurse presenteeism and impairing downstream productivity loss.
Channel integration affects usage intention in food delivery platform services: the mediating effect of perceived value

PurposeStructural equation modeling was conducted, and a sample with 577 consumers was investigated.Design/methodology/approachBased on the stimulus–organism–response (SOR) model, this study aims to explore how channel integration affects usage intention through perceived value in food delivery platform (FDP) services. Moreover, the author also examines the moderating effects of personal innovativeness and experience on the relationships in the model.FindingsThe study found that channel integration affects usage intention through perceived usefulness, perceived enjoyment and perceived price. Moreover, the moderating effects of personal innovativeness and experience are both significant in the model.Research limitations/implicationsThis study found that perceived usefulness, perceived enjoyment and perceived price are three major values influencing the relationship between channel integration and usage intention in FDP services. Moreover, for consumers with high personal innovativeness, perceived usefulness, perceived enjoyment, social image and perceived risk affecting usage intention will be weaker than for consumers with low personal innovativeness. However, for highly experienced consumers, perceived usefulness, perceived enjoyment and perceived price affecting usage intention will be stronger than for less experienced consumers.Practical implicationsThis study suggests that practitioners should develop value-driven innovative services and activities by integrating various channels for customers. Moreover, they should segment consumers on the basis of different levels of personal innovativeness and experience to provide different strategies for increasing the intention to use the service.Originality/valueThis study advances the extant knowledge of the SOR model in the context of online-to-offline commerce.
Phylogeny, evolution, and classification of the ant genus Lasius, the tribe Lasiini and the subfamily Formicinae (Hymenoptera: Formicidae)

Within the Formicidae, the higher classification of nearly all subfamilies has been recently revised given the findings of molecular phylogenetics. Here, we integrate morphology and molecular data to holistically address the evolution, classification, and identification of the ant genus Lasius, its tribe Lasiini, and their subfamily Formicinae. We find that the crown Lasiini originated around the end of the Cretaceous on the Eurasian continent and is divisible into four morphologically distinct clades: Cladomyrma, the Lasius genus group, the Prenolepis genus group, and a previously undetected lineage we name Metalasius gen.nov., with one extant species M. myrmidon comb. nov. and one fossil species, †M. pumilus comb. nov. The crown of the Lasius genus group is considerably younger than that of the Prenolepis genus group, indicating that extinction has played a major role in the evolution of the former clade. Lasius itself is divided into two well‐supported monophyletic groups, which are approximately equally speciose. We present evidence that temporary social parasitism and fungiculture arose twice independently in Lasius. In addition, we recover the paraphyly of three Lasius subgenera and propose replacing all subgenera with an informal species group classification: Lasius = Acanthomyops syn.rev., = Austrolasius syn.nov., = Cautolasius syn.nov., = Chthonolasius syn.nov., = Dendrolasius syn.nov. Total‐evidence analysis reveals that the Baltic‐region amber fossil species †Lasius pumilus and †Pseudolasius boreus are misplaced to genus; we, therefore, create Sussuido gen. nov. to accomodate †S. boreus comb. nov. and transfer †L. pumilus to Metalasius. Further, we transfer †Sussudio and †Glaphyromyrmex out of the Lasiini, considering the former to be incertae sedis in the subfamily, and the latter a member of the Formicini (tribal transfer). Two final taxonomic actions are deemed necessary: synonymy of Lasius escamole with Liometopum apiculatum syn.nov. (subfamilial transfer), and transfer of Paratrechina kohli to Anoplolepis (tribal transfer, forming A. kohli comb.nov.).
Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers

ALKS 7119 is a novel compound with in vitro affinity highest for the SERT, and for μ receptor, α1A‐adrenoceptor, α1B‐adrenoceptor, NMDA receptor and sigma non‐opioid intracellular receptor 1. This first‐in‐human study evaluated safety and PK/PD effects of single ascending doses (SAD) of ALKS 7119 in healthy males and compared effects with neurotransmitter modulators with partially overlapping targets.