Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognosis and Remodeling after Endovascular Repair for Acute, Subacute, and Chronic Type B Aortic Dissection

Purpose: Thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD) is already well introduced, but the best time point to perform TEVAR has not been defined. This study was to report mid- to long-term outcomes and aortic remodeling of TEVAR in patients with TBAD. Materials and Methods: In total, 318 TBAD patients from June 2001 to May 2016 were retrospectively reviewed. Patients were divided into 3 groups depending on interval between dissection onset to TEVAR: acute (0–7 days), subacute (8–30 days), and chronic (>30 days). Clinical and morphological data were collected and analyzed. Results: The follow-up aorta-related mortality rates in the 3 groups were 17.6%, 2.6%, 4.2%, and the proximal stent-induced new entry rates were 11.8%, 1.6%, 2.8%, respectively. Aortic remodeling was satisfied in both the acute and subacute group, but the false lumen diameter did not decrease (p>0.05) in the chronic group. Compared with the VIRTUE classification (acute, 0–14 days; subacute, 15–92 days; chronic, >92 days), mid- to long-term outcomes of patients within the first overlapped interval between the 2 classifications (8–14 days) were similar to that of subacute patients (15–30 days), while aortic remodeling of patients in the second overlapped interval (31–92 days) was similar to that of chronic patients (>92 days). Conclusions: This study suggests that TEVAR for subacute TBAD is associated with a low long-term rate of aorta-related death. Aortic remodeling of chronic dissections is not satisfactory. Additional results suggest that the subacute phase (8–30 days) may be the optimal time to perform TEVAR for uncomplicated TBAD.
How negative emotions affect young and older adults’ numerosity estimation performance

In this study, we investigated the influence of negative emotions on numerosity estimation and whether this influence changes with aging during adulthood. Young and older adults were asked to estimate and compare the numerosity of collections of elements (cars or dots) with a two-digit number. Collections of elements were preceded by emotionally neutral (e.g., mushrooms) or emotionally negative (e.g., a corpse) pictures. Stimuli were easier (i.e., small-ratio) or harder (i.e., large-ratio) items. Young and older participants obtained similar numerosity estimation performance. Interestingly, participants were less accurate under negative emotions than under neutral emotions when they estimated numerosity of collections of abstract elements (i.e., dots). In contrast, participants improved their performance under negative emotions while estimating collections of non-abstract, daily-life elements (i.e., cars). These findings have important implications for furthering our understanding of the role of negative emotions in numerosity estimation and age-related differences therein.
Different Binding Modes of SARS-CoV-1 and SARS-CoV-2 Fusion Peptides to Cell Membranes: The Influence of Peptide Helix Length

Although the amino acid sequences of SARS-CoV-1 and SARS-CoV-2 fusion peptides (FPs) are highly conserved, the cryo-electron microscopy structures of the SARS-CoV-1 and SARS-CoV-2 spike proteins show that the helix length of SARS-CoV-1 FP is longer than that of SARS-CoV-2 FP. In this work, we simulated the membrane-binding models of SARS-CoV-1 and SARS-CoV-2 FPs and compared the binding modes of the FPs with the POPC/POPE/cholesterol bilayer membrane. Our simulation results show that the SARS-CoV-2 FP binds to the bilayer membrane more effectively than the SARS-CoV-1 FP. It is seen that the short N-terminal helix of SARS-CoV-2 FP is more favorable to insert into the target membrane than the long N-terminal helix of SARS-CoV-1 FP. Meanwhile, the potential of mean force calculations showed that the SARS-CoV-2 FP would prefer only one binding mode (N-terminal binding), whereas the SARS-CoV-1 FP has two favorable membrane-binding modes (C-terminal and N-terminal binding modes). Moreover, in the case of SARS-CoV-1 FP binding to the target membrane, the transition between the two binding modes is relatively fast. Finally, we discovered that the membrane-binding mode would influence the helix length of SARS-CoV-1 FP, while the helix length of SARS-CoV-2 FP could be stably maintained in the membrane-bound configurations. This work suggests that the short helix might endow the FP with high membrane-anchoring strength. In particular, the membrane-penetrating residues (Phe, Ile, and Leu) of short α-helix interact with the cell membrane more strongly than those of long α-helix.
Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy

ABSTRACT Podocyte injury leading to albuminuria is a characteristic feature of diabetic nephropathy (DN). Hyperglycemia and advanced glycation end products (AGEs) are major determinants of DN. However, the underlying mechanisms of podocyte injury remain poorly understood. The cytosolic protein TNFAIP2/M-Sec is required for tunneling nanotubes (TNTs) formation, which are membrane channels that transiently connect cells, allowing organelle transfer. Podocytes express TNFAIP2 and form TNTs, but the potential relevance of the TNFAIP2-TNT system in DN is unknown. We studied TNFAIP2 expression in both human and experimental DN and the renal effect of tnfaip2 deletion in streptozotocin-induced DN. Moreover, we explored the role of the TNFAIP2-TNT system in podocytes exposed to diabetes-related insults. TNFAIP2 was overexpressed by podocytes in both human and experimental DN and exposre of podocytes to high glucose and AGEs induced the TNFAIP2-TNT system. In diabetic mice, tnfaip2 deletion exacerbated albuminuria, renal function loss, podocyte injury, and mesangial expansion. Moreover, blockade of the autophagic flux due to lysosomal dysfunction was observed in diabetes-injured podocytes both in vitro and in vivo and exacerbated by tnfaip2 deletion. TNTs allowed autophagosome and lysosome exchange between podocytes, thereby ameliorating AGE-induced lysosomal dysfunction and apoptosis. This protective effect was abolished by tnfaip2 deletion, TNT inhibition, and donor cell lysosome damage. By contrast, Tnfaip2 overexpression enhanced TNT-mediated transfer and prevented AGE-induced autophagy and lysosome dysfunction and apoptosis. In conclusion, TNFAIP2 plays an important protective role in podocytes in the context of DN by allowing TNT-mediated autophagosome and lysosome exchange and may represent a novel druggable target. Abbreviations: AGEs: advanced glycation end products; AKT1: AKT serine/threonine kinase 1; AO: acridine orange; ALs: autolysosomes; APs: autophagosomes; BM: bone marrow; BSA: bovine serum albumin; CTSD: cathepsin D; DIC: differential interference contrast; DN: diabetic nephropathy; FSGS: focal segmental glomerulosclerosis; HG: high glucose; KO: knockout; LAMP1: lysosomal-associated membrane protein 1; LMP: lysosomal membrane permeabilization; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PI3K: phosphoinositide 3-kinase; STZ: streptozotocin; TNF: tumor necrosis factor; TNFAIP2: tumor necrosis factor, alpha-induced protein 2; TNTs: tunneling nanotubes; WT: wild type.
Accelerated epigenetic aging in newborns with Down syndrome

Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early‐onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems. Accelerated epigenetic aging has been found in the blood and brain tissue of adults with DS but when premature aging in DS begins remains unknown. We investigated whether accelerated aging in DS is already detectable in blood at birth. We assessed the association between age acceleration and DS using five epigenetic clocks in 346 newborns with DS and 567 newborns without DS using Illumina MethylationEPIC DNA methylation array data. We compared two epigenetic aging clocks (DNAmSkinBloodClock and pan‐tissue DNAmAge) and three epigenetic gestational age clocks (Haftorn, Knight, and Bohlin) between DS and non‐DS newborns using linear regression adjusting for observed age, sex, batch, deconvoluted blood cell proportions, and genetic ancestry. Targeted sequencing of GATA1 was performed in a subset of 184 newborns with DS to identify somatic mutations associated with transient abnormal myelopoiesis. DS was significantly associated with increased DNAmSkinBloodClock (effect estimate = 0.2442, p < 0.0001), with an epigenetic age acceleration of 244 days in newborns with DS after adjusting for potential confounding factors (95% confidence interval: 196–292 days). We also found evidence of epigenetic age acceleration associated with somatic GATA1 mutations among newborns with DS (p = 0.015). DS was not associated with epigenetic gestational age acceleration. We demonstrate that accelerated epigenetic aging in the blood of DS patients begins prenatally, with implications for the pathophysiology of immunosenescence and other aging‐related traits in DS.
Validity and reliability of the Turkish version of the orthognathic quality of life questionnaire in patients with dentofacial deformity

Background Due to the lack of a specific quality of life (QoL) survey on dentofacial deformities (DFD) for Turkish speakers, the present research aimed to perform a translation of the English version of the Orthognathic Quality of Life Questionnaire (OQLQ) into Turkish (the OQLQ-TR) and provide cultural adaptation to the Turkish population. Material and Methods The process of this cross-cultural adaptation followed the six stages given in the guidelines that were proposed by Beaton et al. (2000), which comprised the following: 1) performing the initial translation, 2) synthesizing the translation, 3) performing the back translation, 4) presenting it to the expert committee, and 5) testing the prefinal version. Throughout the process of validating the Turkish version, the results of the OQLQ were compared with the Oral Health Impact Scale-14 (OHIP-14) and Short Form-36 (SF-36) questionnaires and the Visual Analogue Scale (VAS), which were previously validated in Turkish. All of these Turkish questionnaires (OHIP-14, SF-36, OQLQ) were applied to 69 patients at the Çukurova University Faculty of Dentistry. Results Analysis of the internal consistency of the OQLQ-TR exhibited good correlations for the domains. Moreover, the test-retest reliability also exhibited intra-class correlation coefficients that were excellent. The correlation between the OQLQ-TR and SF-36 was weak and negative. The OQLQ-TR exhibited good correlations with the OHIP-14 and VAS. Conclusions The OQLQ-TR was found to be valid, reliable, and reproducible. Thus, it has become a useful instrument for assessing the quality of life of Turkish-speaking patients with dentofacial deformity. Key words:Dentofacial deformity, orthognathic quality of life, quality of life (QoL), orthognathic surgery.
Depression among COVID-19 survivors in Colombia

ABSTRACT The COVID-19 survivors are at high risk of meeting the criteria for depression. However, few studies have explored its prevalence and associated factors. The study aimed to know the frequency and variables associated with depression among COVID-19 survivors in Santa Marta, Colombia. A sample of COVID-19 survivors was included. Depression was quantified with the Patient Health Questionnaire (PHQ-9, α = 0.85). Three hundred and thirty survivors participated in the research. They were aged between 18 and 89 years, 61.5% were women, and 49.7% of participants scored above the cut-off point for depression. Depression was associated with female gender, younger age, COVID moderate or severe, and having presented symptoms for more than three weeks. In conclusion, depression occurs in half of the COVID-19 survivors and is higher in younger, women and who report more severe symptoms. Longitudinal studies can provide further information on the long-term impact on the mental health of COVID-19 survivors.
Hamiltonian Boundary Value Methods (Energy Conserving Discrete Line Integral Methods)

Recently, a new family of integrators (Hamiltonian Boundary Value Methods) has been introduced, which is able to precisely conserve the energy function of polynomial Hamiltonian systems and to provide a practical conservation of the energy in the non-polynomial case. We settle the definition and the theory of such methods in a mor e general framework. Our aim is on the one hand to give account of their good behavior when applied to general Hamiltonian systems and, on the other hand, to find out what are the optimal formulae, in relation to the choice of the polynomial basis and of the distribution of the nodes. Such analysis is based upon the notion of extended collocation conditionsand the definition of discrete line integral, and is carried out by looking at the limit of such family of methods as the number of the so called silent stages tends to infinity.
THE ROLE OF GUIDANCE AND COUSELING ON THE SELF-ADJUSTMENT OF VOCATIONAL STUDENTS.

The purpose of this is research is to reveal the role of Guidance and Counselling to the self adjustment of the students of vocational students. This study used quantitative approach with survey method. The population of this study was students of Vocational High School. The instrument of data collection was by means of questionnaire. The finding of this study revealed that the Guidance and Counselling gives a significance influence to the self adjustment of the students of vocational students with correlation 0,331 (p value <0,05). The result of this study implied that Vocational High School should empower more seriously attention to the role of Guidance and Counselling to help the students’ adjustment and to increase the students’academic achievement.
Towards optical quantum information processing using Rydberg dark-state polaritons

This thesis proposes a novel method to implement universal quantum gates for photonic qubits using the strong dipole-dipole interactions present in a cold gas of Rydberg atoms and the control offered by microwave fields. By means of electromagnetically induced transparency (EIT) we store the information encoded in photonic qubits as Rydberg excitations, and then couple these to neighbouring states using microwaves. Microwaves alter the range of the dipole-dipole interactions between the excitations, and a suitable geometrical arrangement of the excitations in the cloud leads to a controlled $\pi$ phase shift in the system's wavefunction, the basis of the universal gates proposed. After processing, the excitations in the medium are later retrieved as photons. A theoretical description of the implementation of a 2-qubit universal gate is presented and a numerical analysis shows the feasibility of its implementation in a cold cloud of Rubidium atoms. A scheme is also proposed to construct more general gates with applications in quantum information processing. These schemes have been made possible by the analysis of recent experiments performed in the group. This analysis is repeated here, along with the characterization of parts of the detection system required to obtain them.
(cid:1) -3 and (cid:1) -6 polyunsaturated fatty acids block HERG channels

(cid:1) -3 and (cid:1) -6 polyunsaturated fatty acids block HERG channels. Am J Physiol Cell Physiol C1251–C1260, 2005. polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, which have been attributed to their availability to modulate Na (cid:2) , Ca 2 (cid:2) , and several K (cid:2) channels. However, their effects on human ether-a-go-go -related gene ( HERG ) channels are unknown. In this study we have analyzed the effects of arachidonic acid (AA, (cid:1) -6) and docosahexaenoic acid (DHA, (cid:1) -3) on HERG channels stably expressed in Chinese hamster ovary cells by using the whole cell patch-clamp technique. At 10 (cid:3) M, AA and DHA blocked HERG channels, at the end of 5-s pulses to (cid:4) 10 mV, to a similar extent (37.7 (cid:5) 2.4% vs. 50.2 (cid:5) 8.1%, n (cid:6) 7–10, P (cid:7) 0.05). 5,6,11,14-Eicosatetrayenoic acid, a nonmetabolizable AA analog, induced effects similar to those of AA on HERG current. shifted midpoint of activation curves of channels by 5.1 (cid:5) 1.8 P 0.01). midpoint inactivation curves by (cid:2) 12.0 (cid:5) 3.9 mV ( n (cid:6) 4; P (cid:8) and (cid:2) 15.8 (cid:5) 4.3 (cid:6) 4; higher Finally, both AA and DHA induced a use-dependent inhibition of HERG channels. In summary, block induced by AA and DHA was time, voltage, and use dependent. The results obtained suggest that both PUFAs bind preferentially to the open state of the channel, although an interaction with inactivated HERG channels cannot be ruled out for AA.
The minimum value function for the Tikhonov regularization and its applications

The minimum value function appearing in Tikhonov regularization technique is very useful in determining the regularization parameter, both theoretically and numerically. In this paper, we discuss the properties of the minimum value function. We also propose an efficient method to determine the regularization parameter. A new criterion for the determination of the regularization parameter is also discussed.
Induction of Surfactant Protein in Fetal Lung

Synthesis of surfactant-associated glycoprotein of M, = 30,000-35,000 (SAP-35) was induced in explant culture of human fetal lung otained from 8 to 24 weeks of gestation. SAP-35 synthesis and content increased markedly during 1-5 days in organ culture in association with the morphologic maturation of Type 11 epithelial cells and the appearance of lamellar bodies. [T3] Methionine labeling of the explants and subsequent immunoprecipitation of SAP-35 demonstrated distinct high-mannose precursors and sialylated SAP-35 forms as early in culture as SAP-35 synthesis was detectable. The increase in SAP-35 synthesis was as ociated with increased SAP-35 RNA of 2.1 kilobases as assessed by hybridization assay with [32P]cDNA specific for human SAP-35. Specific SAP-35 RNA increased during organ culture and both SAP-35 content and SAP-35 RNA increased in the absence of exogenous hormones in 2% carbon-stripped fetal calf serum. SAP-35 content and synthesis was stimulated by 8-Br-CAMP. Addition of 100 p~ 8-Br-cAMP, enhanced both the concentration of SAP-35 protein and the SAP-35 RNA as assessed by hybridization assay. In contrast, treatment of the explants with dexamethasone was associated with decreased SAP-35 protein synthesis, SAP-35 content, and decreased SAP-35 RNA levels compared to untreated explants. Inhibition by dexamethasone occurred at all gestational ages tested, was dose-dependent, and detectable within 24-48 h during organ culture. Dexamethasone significantly inhibited both basal and CAMP-induced SAP-35 synthesis. Induction of pulmonary surfactant protein (SAP-35) synthesis during organ culture of human fetal lung was associated with increased SAP-35 RNA. SAP-35 synthesis and SAP-35 RNA were inhibited by dexamethasone and enhanced CAMP.
Are imported cases the reason for the increase in the incidence of clinically diagnosed dengue in Anuradhapura district during the year 2017?

http://doi.org/10.4038/amj.v15i1. 7670 Abstract Dengue has now become endemic in almost all districts of Sri Lanka. An increase in the percentage contribution from North Central Province (NCP) to dengue incidence in the country has been noted since the 2015 dengue outbreak . During the year 2017, 338 patients per 100,000 population were reported to have clinically suspected dengue according to the epidemiology unit records. The daily records available at the dengue control unit of regional of health services office, Anuradhapura, and the freely available data at the epidemiology unit, which comprised of weekly cases of dengue, were extracted and analysed against the meteorological parameters and the vector density data. According to our observations, a statistically significant association between daily rainfall and daily temperature and clinically diagnosed dengue cases does not exist in Anuradhapura. The monthly vector indices did not show any correlation with the monthly incidence of dengue in the medical officer of health area with the highest overall incidence of dengue. The proportion of paediatric patients were also very low in the Anuradhapura district (9%) compared to other districts. Based on these observations, the authors suggest that imported cases of dengue to this district is a major cause of increased incidence of dengue, rather than indigenous transmission in the
GLUTAMINE IN DIET OF LAYING HENS SUBMITTED TO HEAT STRESS AND THERMONEUTRALITY

The aim of this study was to evaluate the effect of glutamine supplementation of the diet on intestinal mucosa morphology, performance, and egg quality of commercial laying hens, submitted to heat stress and thermoneutral conditions. In this study, 96 (Isa Babcock) laying hens at 35 weeks of age were used and distributed in a completely randomized design according to a 2x2 factorial arrangement, with two levels of ambient temperature (thermoneutral and hot) and two levels of glutamine in the diet (0.0 and 1.0% of inclusion), in 6 replicates of 4 hens per box. Feed intake, daily egg production, feed conversion per kilogram of eggs, and egg quality were obtained in two periods of 28 days each. Heat stress decreased egg production and quality, and glutamine supplementation improved egg quality and feed conversion. The heat and glutamine supplementation provided an increase in calliciform cells quantity in duodenum and ileum, respectively. Significant morphological modifications in the intestinal mucosa of laying hens were not found.
Median Unbiased Estimation in FIxed E?ects Dynamic Pan-els

This paper extends Andrews' [1993] median-unbiased estimation for autoregressive/unit root time series to panel data dynamic fixed effects models. It is shown that median-unbiased estimation applies straightforwardly to models that include linear time trends as well as to those including more general time specific effects. Using Monte Carlo simulations, median-unbiased LSDV estimators are computed and found to be robust to groupwise heteroskedastic and cross-sectionally correlated disturbances. The behavior of these estimators in the presence of exogenous regressors as well as AR parameter heterogeneity is also evaluated in this paper. As an application, these estimators are used to evaluate conditional convergence in the cases of 48 USA states, 13 OECD countries, and two wider samples from Summers and Heston's Penn World Tables, with 57 and 100 countries. It is found that median-unbiased estimates support conditional convergence only among USA states and OECD countries.
Some New Maps and Ideals in Classical Iwasawa Theory with Applications

We introduce a new ideal {\mathfrak D} of the p-adic Galois group-ring associated to a real abelian field and a related ideal {\mathfrak J} for imaginary abelian fields. Both result from an equivariant, Kummer-type pairing applied to Stark units in a Z_p-tower of abelian fields and {\mathfrak J} is linked by explicit reciprocity to a third ideal {\mathfrak S} studied more generally in a previous work. This leads to a new and unifying framework for the Iwasawa Theory of such fields including a real analogue of Stickelberger's Theorem, links with certain Fitting ideals and \Lambda-torsion submodules, and a new exact sequence related to the Main Conjecture.