Miracle-dz/UniFAR-FTUs huggingface dataset:
Synthetic hemoglobin‐based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion

Normothermic machine perfusion presents a novel platform for pretransplant assessment and reconditioning of kidney grafts. Maintaining the metabolic activity of a preserved graft at physiologic levels requires an adequate oxygen supply, typically delivered by crystalloid solutions supplemented with red blood cells. In this study, we explored the feasibility of using a synthetic hemoglobin‐based oxygen carrier (HBOC) in human kidney normothermic perfusion. Fourteen discarded human kidneys were perfused for 6 hours at a mean temperature of 37°C using a pressure‐controlled system. Kidneys were perfused with a perfusion solution supplemented with either HBOC (n = 7) or packed red blood cells (PRBC) (n = 7) to increase oxygen‐carrying capacity. Renal artery resistance, oxygen extraction, metabolic activity, energy stores, and histological features were evaluated. Throughout perfusion, kidneys from both groups exhibited comparable behavior regarding vascular flow (P = .66), oxygen consumption (P = .88), and reconstitution of tissue adenosine triphosphate (P = .057). Lactic acid levels were significantly higher in kidneys perfused with PRBC (P = .007). Histological findings were comparable between groups, and there was no evidence of histological damage caused by the HBOC. This feasibility experiment demonstrates that a HBOC solution can offer a logistically more convenient off‐the‐shelf alternative to PRBC in normothermic machine perfusion of human kidneys.
Program TV Bocah Petualang Tema Pegunungan Sebagai Pemantik Kreativitas Berkarya Anak

Tujuan penelitian ini adalah untuk mengetahui tingkat kreativitas yang dimiliki oleh siswa melalui Program TV Tema Gunung Bocah Petualang sebagai Perancang Kreativitas Anak SD N Peterongan Semarang. Penelitian ini menggunakan pendekatan kualitatif dengan metode fenomenologis. Pengumpulan data dalam penelitian ini dilakukan melalui observasi, kuesioner, wawancara dan dokumentasi. Validitas data dilakukan dengan triangulasi sumber. Hasil penelitian data yaitu tingginya tingkat program TV Bocah Petualang yang memengaruhi kreativitas siswa, selain mampu mengembangkan ide dan menyelesaikan masalah yang dihadapi ketika mengalami kesulitan, siswa juga dapat mengkomunikasikan apa yang mereka ketahui kepada teman atau orang tua.
Clinical outcomes of polyvalent immunoglobulin use in solid organ transplant recipients: A systematic review and meta‐analysis

Polyvalent immunoglobulin is commonly used for desensitization and treatment of antibody‐mediated rejection in kidney transplantation but its impact on other outcomes is not known. This systematic review investigated the impact of immunoglobulin prophylaxis on infection, rejection, graft loss, and death following kidney transplantation. A comprehensive literature search located 18 studies (n = 8 randomized controlled trials). None examined the effect of immunoglobulin prophylaxis in transplant recipients with hypogammaglobulinemia. Quality of included studies was variable with high to very high risk of bias. In the randomized trials, immunoglobulin use did not reduce cytomegalovirus infection (OR 0.68 [0.39, 1.21]; 6 studies, n = 295), rejection (OR 0.96 [0.50, 1.82]; 4 studies, n = 187), or graft loss (OR 1.03 [0.46, 2.30]; 6 studies, n = 265). In non‐randomized studies, immunoglobulin did not reduce cytomegalovirus infection (OR 0.63 [0.20, 1.94]; 6 studies, n = 361) or death (OR 1.32 [0.05, 38.79]; 3 studies, n = 222) but reduce rejection (OR 0.47 [0.24, 0.94]; 4 studies, n = 268) and graft loss (OR 0.15 [0.05, 0.43]; 2 studies, n = 118). Data were scarce and sample size of current evidence was small. Adequately powered randomized trials are needed to determine if immunoglobulin is an effective intervention to reduce infection, rejection, graft loss, or death following kidney transplantation with and without hypogammaglobulinemia.
Strange-face illusions during eye-to-eye gazing in dyads: specific effects on derealization, depersonalization and dissociative identity

ABSTRACT Experimentally induced strange-face illusions can be perceived when two individuals look at each other in the eyes under low illumination for about 10 minutes. This task of subject-other eye-to-eye gazing produces the following perceptions by the subject: (i) mild to huge deformations and color/shape changes of face and facial features; (ii) lifeless, unmoving faces and immaterial presences akin to out-of-body experiences; (iii) pseudo-hallucinations, enlightened ‘idealized’ faces and personalities – rather than the other’s actual face. Dissociative phenomena seem to be involved, whereas the effects of non-pathological dissociation on strange-face illusions have not yet been directly investigated. In the present study, dissociative perceptions and strange-face illusions were measured through self-report questionnaires on a large sample (N = 90) of healthy young individuals. Results of correlation and factor analyses suggest that strange-face illusions can involve, respectively: (i) strange-face illusions correlated to derealization; (ii) strange-face illusions correlated to depersonalization; and (iii) strange-face illusions of identity, which are supposedly correlated to identity dissociation. The findings support the separation between detachment and compartmentalization in dissociative processes. Effects of gender show that strange-face illusions are more frequent in men with respect to women if dyads are composed of individuals of different-gender. Furthermore, drawings of strange-faces, which were perceived by portrait artists in place the others’ faces, allowed a direct illustration of examples of dissociative identities. Findings are discussed in relation to the three-level model of self-referential processing.
Inclusive leadership and career adaptability: the mediating role of organization-based self-esteem and the moderating role of organizational justice

ABSTRACT The objective of this research is to test the impact of supervisor inclusive leadership on subordinate career adaptability skill, as well as conceptualized the organization-based self-esteem (OBSE) as a mediator and organizational justice as a moderator in this relation. Data were gathered applying two-way research design for survey. Respondents were drawn from 297 subordinates and 98 supervisors from higher education institutions of Pakistan. Monte Carlo simulation method, moderated path analysis and hierarchical regression were applied to examine the proposed associations. OBSE mediated the relationship of inclusive leadership and career adaptability. Both the association among OBSE and career adaptability and the indirect association among inclusive leadership and career adaptability were stronger when organizational justice was high. This research implications and limitations are also added.
Multidimensional emotion regulation strategies among hospice nurses

Abstract The purpose of this study was to investigate relationships between four emotion regulation strategies (intrinsic affect-improving, intrinsic affect-worsening, extrinsic affect-improving, and extrinsic affect-worsening) and compassion fatigue, job satisfaction, and life satisfaction among 90 hospice nurses who completed an online survey. Intrinsic affect-improving was associated with higher life satisfaction. Intrinsic affect-worsening was associated with higher compassion fatigue and lower life satisfaction. Extrinsic affect-worsening was associated with lower job satisfaction. Overall, these findings support a multidimensional approach to understanding emotion regulation among hospice nurses.
Micromechanically-motivated phase field approach to ductile fracture

Utilization of the phase-field diffusive crack approach in prediction of crack evolution in materials containing voids is investigated herein. It has been established that the ductile failure occurs predominantly due to nucleation, growth and coalescence of micro-voids and micro-cavities, which lead to initiation and propagation of cracks till final material collapse. This study is an attempt to model the material internal degradation with the Rousselier pressure-dependent plasticity law, assisted with the phase field diffusive crack approach for the first time, in order to account for the post-critical softening regime. Such treatment requires the utilization of a damage evolution law and a crack initiation criterion which triggers the succeeding crack propagation, whereby a modified crack driving force based on the sequence of internal damage is employed. In numerical terms, the proposed model is integrated within a fully-staggered framework for the mechanical and diffusive fields and is implemented via the finite element method. The verification tests on the model is processed by several examples with the focus on both qualitative monitoring of pathological crack patterns and the quantitative analysis on the material response, particularly in the post-critical range, complemented by relevant comparisons with the existing data from literature.
Knowledge, attitudes, beliefs and practices of obstetrics-gynecologists on seasonal influenza and pertussis immunizations in pregnant women: preliminary results from North-Western Italy.

BACKGROUND Italian National Immunization Plan (NIP) 2017-2019 has introduced new recommendations regarding immunization practices during pregnancy. In this cross sectional study, we documented specific knowledge, attitudes, and practices (KAP) in a sample of obstetrician-gynecologists (OBGYN). METHODS A total of 68 OBGYN (39.7% of males, mean age of 47.7 ± 9.3 years old) compiled a structured online-questionnaire. Participants were asked about: knowledge of vaccine issues (both in general and regarding NIP recommendations for pregnant women); actual performance/recommendation of seasonal influenza (SID) and tetanus-diphtheria- acellular pertussis vaccinations (Tdap); risk perception about SID and pertussis. Eventually, a regression analysis was performed in order to identify predictive factors for vaccine propensity. RESULTS Although most OBGYN were aware of official recommendations, only 57.4% and 55.9% correctly recalled the appropriate timing for vaccinations shots for SID and Tdap. Overall, 79.4% and 67.6% of participants usually delivered or recommended SID and Tdap to pregnant women, respectively. Main perceived barriers were identified by OBGYN in patients' fear of side effects (89.7%), their low risk perception (82.3%), insufficient awareness of official recommendations among pregnant women (75.0%). Significant predictors of Tdap practice were identified in higher risk perception (OR 6.466, 95%CI 1.077; 38.803) and better knowledge of official recommendations (OR 7.310, 95%CI 1.195; 44.704), whereas SID was apparently unrelated with individual characteristics of participants. CONCLUSIONS Sampled OBGYN were largely favorable towards vaccination of pregnant women. As knowledge of official recommendations was identified as a main predictor of appropriate behavior at least for Tdap practice, future educational interventions could eventually improve immunization rates.
VERDICT MRI for Prostate Cancer: Intracellular Volume Fraction versus Apparent Diffusion Coefficient

Background Biologic specificity of diffusion MRI in relation to prostate cancer aggressiveness may improve by examining separate components of the diffusion MRI signal. The Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumors (VERDICT) model estimates three distinct signal components and associates them to (a) intracellular water, (b) water in the extracellular extravascular space, and (c) water in the microvasculature. Purpose To evaluate the repeatability, image quality, and diagnostic utility of intracellular volume fraction (FIC) maps obtained with VERDICT prostate MRI and to compare those maps with apparent diffusion coefficient (ADC) maps for Gleason grade differentiation. Materials and Methods Seventy men (median age, 62.2 years; range, 49.5–82.0 years) suspected of having prostate cancer or undergoing active surveillance were recruited to a prospective study between April 2016 and October 2017. All men underwent multiparametric prostate and VERDICT MRI. Forty-two of the 70 men (median age, 67.7 years; range, 50.0–82.0 years) underwent two VERDICT MRI acquisitions to assess repeatability of FIC measurements obtained with VERDICT MRI. Repeatability was measured with use of intraclass correlation coefficients (ICCs). The image quality of FIC and ADC maps was independently evaluated by two board-certified radiologists. Forty-two men (median age, 64.8 years; range, 49.5–79.6 years) underwent targeted biopsy, which enabled comparison of FIC and ADC metrics in the differentiation between Gleason grades. Results VERDICT MRI FIC demonstrated ICCs of 0.87–0.95. There was no significant difference between image quality of ADC and FIC maps (score, 3.1 vs 3.3, respectively; P = .90). FIC was higher in lesions with a Gleason grade of at least 3+4 compared with benign and/or Gleason grade 3+3 lesions (mean, 0.49 ± 0.17 vs 0.31 ± 0.12, respectively; P = .002). The difference in ADC between these groups did not reach statistical significance (mean, 1.42 vs 1.16 × 10-3 mm2/sec; P = .26). Conclusion Fractional intracellular volume demonstrates high repeatability and image quality and enables better differentiation of a Gleason 4 component cancer from benign and/or Gleason 3+3 histology than apparent diffusion coefficient. Published under a CC BY 4.0 license. Online supplemental material is available for this article. See also the editorial by Sigmund and Rosenkrantz in this issue.
Transition to higher education; prospective and retrospective student experiences

Pre-university (foundation or Level 3) study attracts significant student numbers annually, but approximately 10% of successful Level 3 students do not progress into their university degrees. This project aimed to identify the experiences of current and previous Level 3 students, using questionnaires and focus groups to explore differences by gender, ethnicity and intention to study. One hundred and two current and 56 previous level 3 students participated. Those who felt part of the university were significantly more likely to agree that the foundation course met their expectations. Personal support from academic staff, was highly ranked by students in all year groups, peaking in the final year. Despite considerable student diversity, the foundation year met expectations. However this was significantly lower for Black students compared with other ethnicities, which needs further exploration. Fostering ‘belonging’ to university is important for foundation year students to improve retention rates into their degree courses.
Thermodynamics of Active Field Theories: Energetic Cost of Coupling to Reservoirs

The hallmark of active matter is the autonomous directed motion of its microscopic constituents driven by consumption of energy resources. This leads to the emergence of large scale dynamics and structures without any equilibrium equivalent. Though active field theories offer a useful hydrodynamic description, it is unclear how to properly quantify the energetic cost of the dynamics from such a coarse-grained description. We provide a thermodynamically consistent framework to identify the energy exchanges between active systems and their surrounding thermostat at the hydrodynamic level. Based on linear irreversible thermodynamics, we determine how active fields couple with the underlying reservoirs at the basis of nonequilibrium driving. This leads to evaluating the rate of heat dissipated in the thermostat, as a measure of the cost to sustain the system far from equilibrium, which is related to the irreversibility of the active field dynamics. We demonstrate the applicability of our approach in two popular active field theories: (i) the dynamics of a conserved density field reproducing active phase separation, and (ii) the coupled dynamics of density and polarization describing motile deformable droplets. Combining numerical and analytical approaches, we provide spatial maps of dissipated heat, compare them with the irreversibility measure of the active field dynamics, and explore how the overall dissipated heat varies with the emerging order.
Radiation‐induced genomic instability in breast carcinomas of the Swedish hemangioma cohort

Radiation‐induced genomic instability (GI) is hypothesized to persist after exposure and ultimately promote carcinogenesis. Based on the absorbed dose to the breast, an increased risk of developing breast cancer was shown in the Swedish hemangioma cohort that was treated with radium‐226 for skin hemangioma as infants. Here, we screened 31 primary breast carcinomas for genetic alterations using the OncoScan CNV Plus Assay to assess GI and chromothripsis‐like patterns associated with the absorbed dose to the breast. Higher absorbed doses were associated with increased numbers of copy number alterations in the tumor genome and thus a more unstable genome. Hence, the observed dose‐dependent GI in the tumor genome is a measurable manifestation of the long‐term effects of irradiation. We developed a highly predictive Cox regression model for overall survival based on the interaction between absorbed dose and GI. The Swedish hemangioma cohort is a valuable cohort to investigate the biological relationship between absorbed dose and GI in irradiated humans. This work gives a biological basis for improved risk assessment to minimize carcinogenesis as a secondary disease after radiation therapy.
Acute stress enhances the sensitivity for facial emotions: a signal detection approach

Abstract Facial emotion recognition is an important prerequisite for social cognition. There is, however, limited evidence on how the ability to detect facial emotions is influenced by acute stress and the associated physiological reactions. In this study, two groups of healthy male participants were either exposed to a psychosocial stressor – an adaptation of the Trier Social Stress Test in virtual reality (n = 23) – or a non-stressful control task in the virtual environment (n = 20). Afterwards, both groups completed a computerized facial recognition task based on the signal detection theory presenting happy vs. angry faces with three different expression intensities. Saliva samples were taken at seven time points over the course of the experiment and used to analyze concentrations of free salivary cortisol and alpha amylase. Analyses using repeated-measures analyses of variance revealed a significant increase in emotion detection performance and significantly shorter response latencies in the stress group independent of emotional valence or emotion intensity. However, increased task performance in the stress group could not be predicted by stress-induced cortisol or alpha amylase secretion. The results suggest that enhanced detection of emotional cues after stress might be an adaptive response as an increased sensitivity to social cues might help individuals to detect potential threats or sources of social support in their social environment. Lay Summary Socially evaluative stress facilitates the subsequent recognition of emotions. After having performed a task in a virtual environment, two groups of participants were asked to detect emotion expressions on pictures of faces that were presented to them on a computer screen. Statistical comparison of groups indicates that the group that had previously been subjected to a stressful job interview showed better results and became faster in detecting displayed emotions than the control group that had previously performed a non-stressful task.
Prevalence of Parasitic Intestinal Infections Among Food Handlers in Qazvin, İran

Objective Food handlers play an important role in the production and distribution of parasitic contaminations in these societies. The aim of this study was to assess the prevalence of intestinal parasitic infections among the food handlers in Qazvin, Iran. Methods Totally, 1530 stool samples were collected from food handlers in Qazvin, Iran. Direct feces examination and formalinethyl acetate concentration method followed by Trichrome staining were performed to detect the parasites. Results The prevalence of intestinal parasites was 82 (5.4%) among food handlers. The species of protozoan parasites found were Blastocystis hominis, Giardia lamblia, Entamoeba coli, and Endolimax nana. The outbreaks of Blastocystis hominis (2.9%), and Endolimax nana (0.3%) were the most and the least protozoan infections observed among the specimens, respectively. Also, there was no helminthic infection detected among the samples. The prevalence of intestinal parasites among the food handlers, based on variables including sex, age, job, and education, did not differ, whereas the prevalence of intestinal symptoms was shown to be higher in infected food handlers (p<0.05). Conclusions Despite a decrease in the incidence of intestinal parasites, the protozoan infections are still among the health concerns in these areas. Therefore, continuous monitoring and training of food handlers by local health authorities should be performed on a regular basis.
Are There Differences in Anti-Gay Beliefs Among U.S. Veterans and Non-Veterans? Results from the General Social Survey

ABSTRACT Only since 2011 have sexual minorities been able to serve openly in the U.S. military. The previous anti-gay policies and culture of the military may have increased anti-gay beliefs among veterans. Using data from the 2010–2016 General Social Survey, we tested whether veterans more frequently endorsed anti-gay beliefs than their non-veteran peers. Adjusting for sociodemographic characteristics with multiple logistic regression, we tested the associations of veteran status with five anti-gay beliefs (i.e., disallowing a gay person (1) from publicly speaking or (2) teaching at a university, (3) removing a gay-supportive book from a library, (4) whether same-sex sexual relations are wrong, and (5) support of same-sex marriage. Veteran status was associated with greater disagreement with same-sex marriage (B = 0.16, p = 0.033) but not with other anti-gay beliefs. Most anti-gay beliefs among veterans were explained by other sociodemographic factors and may not be inherent to veteran status.