Miracle-dz/UniFAR-FTUs huggingface dataset:
Elevated fear states facilitate ventral hippocampal engagement of basolateral amygdala neuronal activity

Fear memory formation and retention rely on the activation of distributed neural circuits. The basolateral amygdala (BLA) and ventral hippocampus (VH) in particular are two regions that support contextual fear memory processes and share reciprocal connections. The VH → BLA pathway is critical for increases in fear after initial learning, in both fear renewal following extinction learning and during fear generalization. This raises the possibility that functional changes in VH projections to the BLA support increases in learned fear. In line with this, fear can also be increased with alterations to the original content of the memory via reconsolidation, as in fear elevation procedures. However, very little is known about the functional changes in the VH → BLA pathway supporting reconsolidation-related increases in fear. In this study, we used in vivo extracellular electrophysiology to examine the functional neuronal changes within the BLA and in the VH → BLA pathway as a result of fear elevation and standard fear retrieval procedures. Elevated fear expression was accompanied by higher BLA spontaneous firing compared to a standard fear retrieval condition. Across a range of stimulation frequencies, we also found that VH stimulation evoked higher BLA firing following fear elevation compared to standard retrieval. These results suggest that fear elevation is associated with an increased capacity of the VH to drive neuronal activity in the BLA, highlighting a potential circuit involved in strengthening existing fear memories.
COBRA 2006 PROCEEDINGS OF THE ANNUAL RESEARCH CONFERENCE OF THE ROYAL INSTITUTION OF CHARTERED SURVEYORS

The construction industry is traditionally considered a white, male-dominated industry. The UK construction industry is at its busiest for a decade and is suffering from skill shortages in both craft and manual trades, and at the professional level. The issue regarding the lack of women in construction has become more prominent recently, attracting government and industry-wide attention due to this potential skill shortage facing the industry. To meet these targets the industry cannot rely on recruiting the traditional male-dominated workforce. Therefore the UK government is examining ways to encourage women into traditionally male-dominated jobs. Since then a number of initiatives have been introduced promoting construction careers to women; however they have yet to achieve the desired effect. The main aim of this paper is to investigate how the construction industry can successfully recruit and retain professional women by looking at what lessons can be learnt from other sectors such as medicine. Hence this paper looks into other sectors, in particular the medical sector and how it has become an accessible career for women. It also focuses on the culture of other sectors to establish the influence this has over the employment of female professionals.
Post-Disaster Emergency Communications Enhanced by Drones and Non-Orthogonal Multiple Access : Three-Dimensional Deployment Optimization and Spectrum Allocation

Integrating the relaying drone and non-orthogonal multiple access (NOMA) technique into post-disaster emergency communications (PDEComs) is a promising way to accomplish efficient network recovery. Motivated by the above, by optimizing the drone three-dimensional (3D) deployment optimization and spectrum allocation, this paper investigates a quality of service (QoS)-driven sum rate maximization problem for drone-and-NOMA-enhanced PDEComs that aims to improve the data rate of cell edge users (CEUs). Due to the non-deterministic polynomial (NP)-hard characteristics, we first decouple the formulated problem. Next, we obtain the optimal 3D deployment with the aid of a long short-term memory (LSTM)-based recurrent neural network (RNN). Then, we transform the spectrum allocation problem into an optimal matching issue, based on which the Hungarian algorithm is employed to solve it. Finally, the simulation results show that the presented scheme has a significant performance improvement in the sum rate compared with the state-of-the-art works and benchmark scheme. For instance, by adopting the NOMA technique, the sum rate can be increased by 9.72% and the needs of CEUs can be satisfied by enabling the relaying drone. Additionally, the convergence, complexity, and performance gap caused by iterative optimization are discussed and analyzed.
Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP

Neurological disorders such as Parkinsonism cause serious socio-economic problems as there are, at present, only therapies that treat their symptoms. The well-established hallmark alpha-synuclein (SYN) is enriched in the inclusion bodies characteristic of Parkinsonism. We discovered a prominent partner of SYN, termed Tubulin Polymerization Promoting Protein (TPPP), which has important physiological and pathological activities such as the regulation of the microtubule network and the promotion of SYN aggregation. The role of TPPP in Parkinsonism is often neglected in research, which we here attempt to remedy. In the normal brain, SYN and TPPP are expressed endogenously in neurons and oligodendrocytes, respectively, whilst, at an early stage of Parkinsonism, soluble hetero-associations of these proteins are found in both cell types. The cell-to-cell transmission of these proteins, which is central to disease progression, provides a unique situation for specific drug targeting. Different strategies for intervention and for the discovery of biomarkers include (i) interface targeting of the SYN-TPPP hetero-complex; (ii) proteolytic degradation of SYN and/or TPPP using the PROTAC technology; and (iii) depletion of the proteins by miRNA technology. We also discuss the potential roles of SYN and TPPP in the phenotype stabilization of neurons and oligodendrocytes.
Mineralogy of mafic xenoliths and their reaction zones in the olivine lamproite from Prairie Creek Arkansas and the paragenesis of haggertyite, Ba [Fe6Ti5Mg]O19

Abstract The recently discovered mineral haggertyite, which belongs to the magnetoplumbite family, occurs in the Prairie Creek lamproite exclusively in a reaction zone at the contact between the olivine lamproite and serpentized xenoliths. Compositional characteristics of the lamproite are an extreme enrichment in elements such as K, Ba, and Ti, associated with very low Al2O3. Based on textural evidence, it appears that the xenoliths represent a quenched very mafic magma, possibly komatiitic. An absence of perovskite in the reaction zone is the consequence of Si diffusion from the xenolith. Iron available in the xenolith may be the controlling factor for the crystallization of haggertyite and other Fe- and Ti-oxides involved in the reaction. Other elements (K, Ti, and Ba) diffused from the lamproite toward the xenolith zone but only the outermost edge of the xenoliths reacted. The crystallization of haggertyite appears to have resulted from a local chemical environment created by element diffusion between the two significantly contrasting lithologies.
The Effect of Leisure Intervention on Occupational Performance and Occupational Balance in Individuals with Substance Use Disorder: A Pilot Study

Methods The sample for this quasiexperimental pretest–posttest with a two-month follow-up design comprised nine individuals aged between 18 and 55 years, selected using a convenience sampling method. The intervention consisted of a 2-month group leisure participation program, conducted twice a week, followed by a 2-month follow-up period. Primary outcome measures included occupational performance and occupational balance, and secondary outcome measures were leisure participation, quality of life, and drug craving. Outcome measures were assessed three times: preintervention, postintervention, and after the follow-up period. The outcome measures included the Canadian Occupational Performance Measure (COPM), Occupational Balance Questionnaire-11 (OBQ11), Nottingham Leisure Questionnaire (NLQ), 36-Item Short-Form Health Survey (SF-36), and Desire to Drug Questionnaire (DDQ). Data analysis was performed using the Friedman test and Wilcoxon signed-rank test as a post hoc procedure, with a significance level set at 5%. Results The findings showed significant improvements in participants' occupational performance in postintervention and follow-up assessments (p < 0.01, r = 0.59) and better occupational balance from pre- to postintervention (p < 0.01, r = 0.59) and after the follow-up period (p < 0.01, r = 0.60). Furthermore, significant enhancements were observed in leisure participation, quality of life, and a reduction in drug craving. Conclusion The findings indicate that leisure intervention positively impacted both occupational performance and occupational balance, suggesting its potential as a beneficial therapeutic approach for individuals with substance use disorder. Additional research is warranted to delve deeper into and validate the effectiveness of leisure intervention within this specific population.
The World's Longest-Lived Corporate Group: Lithic Analysis Reveals Prehistoric Social Organization near Lillooet, British Columbia

The ability to identify distinct types of cherts and chalcedonies at the large prehistoric housepit site of Keatley Creek on the British Columbia plateau has made it possible to infer important aspects of socioeconomic organization from ca. 2400 to 1100 B.P. Each large housepit tested at the site appears to have a distinctive and characteristic composition of chert and chalcedony debitage which remains coherent over time (for at least 1,000 years). Three inferences concerning socioeconomic organization are derived from these observations: (1) residents of each large housepit probably foraged in distinctly different ranges during nonwinter months where they procured their raw stone materials; (2) residents of each large pithouse formed “residential corporate groups” that differed in their access to stone resources; and (3) the “residential corporate groups” that occupied large pithouses retained economic rights, corporate identity, and ownership of specific pithouse premises for unusually long time periods spanning more than a millennium. Differences between lithic assemblages of housepits were confirmed by three separate and independent analyses employing successively more sophisticated techniques.
Different Forms of TFF3 in the Human Endocervix, including a Complex with IgG Fc Binding Protein (FCGBP), and Further Aspects of the Cervico-Vaginal Innate Immune Barrier

TFF3 is a typical secretory poplypeptide of mucous epithelia belonging to the trefoil factor family (TFF) of lectins. In the intestine, respiratory tract, and saliva, TFF3 mainly exists as a high-molecular-mass complex with IgG Fc binding protein (FCGBP), which is indicative of a role in mucosal innate immunity. For the first time, we identified different forms of TFF3 in the endocervix, i.e., monomeric and homodimeric TFF3, as well as a high-molecular-mass TFF3-FCGBP complex; the latter also exists in a hardly soluble form. Immunohistochemistry co-localized TFF3 and FCGBP. Expression analyses of endocervical and post-menopausal vaginal specimens revealed a lack of mucin and TFF3 transcripts in the vaginal specimens. In contrast, genes encoding other typical components of the innate immune defense were expressed in both the endocervix and vagina. Of note, FCGBP is possibly fucosylated. Endocervical specimens from transgender individuals after hormonal therapy showed diminished expression, particularly of FCGBP. Furthermore, mucus swabs from the endocervix and vagina were analyzed concerning TFF3, FCGBP, and lysozyme. It was the aim of this study to illuminate several aspects of the cervico-vaginal innate immune barrier, which is clinically relevant as bacterial and viral infections are also linked to infertility, pre-term birth and cervical cancer.
Genomic Insights into High-Altitude Adaptation: A Comparative Analysis of Roscoea alpina and R. purpurea in the Himalayas

Environmental stress at high altitudes drives the development of distinct adaptive mechanisms in plants. However, studies exploring the genetic adaptive mechanisms of high-altitude plant species are scarce. In the present study, we explored the high-altitude adaptive mechanisms of plants in the Himalayas through whole-genome resequencing. We studied two widespread members of the Himalayan endemic alpine genus Roscoea (Zingiberaceae): R. alpina (a selfing species) and R. purpurea (an outcrossing species). These species are distributed widely in the Himalayas with distinct non-overlapping altitude distributions; R. alpina is distributed at higher elevations, and R. purpurea occurs at lower elevations. Compared to R. purpurea, R. alpina exhibited higher levels of linkage disequilibrium, Tajima’s D, and inbreeding coefficient, as well as lower recombination rates and genetic diversity. Approximately 96.3% of the genes in the reference genome underwent significant genetic divergence (FST ≥ 0.25). We reported 58 completely divergent genes (FST = 1), of which only 17 genes were annotated with specific functions. The functions of these genes were primarily related to adapting to the specific characteristics of high-altitude environments. Our findings provide novel insights into how evolutionary innovations promote the adaptation of mountain alpine species to high altitudes and harsh habitats.
Exhaled Breath Analysis Detects the Clearance of Staphylococcus aureus from the Airways of Children with Cystic Fibrosis

Background: Electronic nose (eNose) technology can be used to characterize volatile organic compound (VOC) mixes in breath. While previous reports have shown that eNose can detect lung infections with pathogens such as Staphylococcus aureus (SA) in people with cystic fibrosis (CF), the clinical utility of eNose for longitudinally monitoring SA infection status is unknown. Methods: In this longitudinal study, a cloud-connected eNose, the SpiroNose, was used for the breath profile analysis of children with CF at two stable visits and compared based on changes in SA infection status between visits. Data analysis involved advanced sensor signal processing, ambient correction, and statistics based on the comparison of breath profiles between baseline and follow-up visits. Results: Seventy-two children with CF, with a mean (IQR) age of 13.8 (9.8–16.4) years, were studied. In those with SA-positive airway cultures at baseline but SA-negative cultures at follow-up (n = 19), significant signal differences were detected between Baseline and Follow-up at three distinct eNose sensors, i.e., S4 (p = 0.047), S6 (p = 0.014), and S7 (p = 0.014). Sensor signal changes with the clearance of SA from airways were unrelated to antibiotic treatment. No changes in sensor signals were seen in patients with unchanged infection status between visits. Conclusions: Our results demonstrate the potential applicability of the eNose as a non-invasive clinical tool to longitudinally monitor pulmonary SA infection status in children with CF.
Radial Arterial Cannulation by Ultrasound-Guided Dynamic Needle-Tip Positioning Using the Short-Axis Out-of-Plane Approach Versus the Long-Axis In-Plane Approach: A Randomized Controlled Study

Introduction Radial artery cannulation is a commonly performed invasive procedure for assessing a patient's hemodynamic status and collecting blood samples. Ultrasound guidance has shown benefits in improving the success rate of first-attempt cannulation. Two main approaches, short-axis out-of-plane (SAOOP) and long-axis in-plane (LAIP), are commonly used. A modified technique called dynamic needle-tip positioning (DNTP) using the short-axis out-of-plane approach has been reported to enhance arterial catheterization. This study aims to compare the first-attempt success rates of radial artery cannulation using the two techniques, DNTP versus LAIP, along with overall success rates, cannulation time, and number of attempts. Methods This prospective, randomized, controlled, clinical study was conducted after obtaining clearance from the Institute Ethics Committee of AIIMS, Raipur. Ninety-six patients between the ages of 18 and 50 years, undergoing elective surgery under general anesthesia, and required radial arterial cannulation were randomized and equally allocated into two groups as the LAIP and DNTP approaches. The first-pass success rate, time to achieve successful cannulation, number of attempts needed, overall success rate within five minutes, and potential complications, such as thrombosis, vasospasm, and hematoma, were recorded. Results A total of 96 patients were included, with 48 in the LAIP group and 48 in the DNTP group. The DNTP group showed statistically significant advantages over the LAIP group, with a higher first-pass success rate (97.9% vs. 83.3%; p = 0.014) and shorter time to achieve successful cannulation (9.29±3.79 vs. 26.16±20.22 seconds; p = 0.001). Conclusion The ultrasound-guided short-axis DNTP technique for radial artery cannulation demonstrated a significant advantage as compared to the LAIP technique. The DNTP technique resulted in higher first-attempt cannulation success and shorter cannulation time.
Drift and the development of sentential complements in British and American English from 1700 to the present day

Sentential complementation, i.e. the situation that arises when a subordinate clause functions as an argument with respect to a governing element or head, as in “I think that it is a good idea” or “To refuse her request would be unthinkable”, has been a prolific area of research for many years among English historical linguists; see, among others, Warner (1982), Fischer (1988, 1989, 1995), Fanego (1990, 1992, 1996a/b/c, 1997, 2004a/b, 2006), Rohdenburg (1995, 1996, 2006), Los (1998, 2005), Rudanko (1998, 1999, 2000), Miller (2002), Wagner (2002), Vosberg (2003a/b, 2004) or, more recently, De Smet (2004, 2005) and De Smet/Cuykens (2005). Many of these studies have focused on Old, Middle and Early Modern English, while comparatively little work has been done on Late Modern and Presentday English, the main exceptions being some of the publications by
Modelling Climate Variability and Climate Change and Their Associated Effects on Highland Cooking Banana Production in Uganda

5 TABLE OF CONTENTS . 8 LIST OF TABLES . 12 LIST OF FIGURES . 15 LIST OF ACRONYMS AND ABBREVIATIONS . 28 OPERATIONAL DEFINITION OF TERMS . 31
The earthquake performance of stone-masonry basilica churches in Kefalonia-Greece including wall detachment and soil-foundation deformability

The dynamic and earthquake performance Post-Byzantine Christian churches located in Greece is examined. These churches developed damage to their stone masonry walls due to gravitational forces acting together with seismic forces. The results from 3-D numerical linear dynamic analyses, utilizing recorded ground motions, together with assumed strength values are employed to predict the behaviour of the various masonry parts. Use is made of the deformability of the foundation and is shown that this deformability partly explains the appearance of structural damage. The performance of the various vertical masonry walls is examined by a process whereby the demands at critical locations are compared with the corresponding bearing capacities in either in-plane shear/flexure or in out-of-plane flexure. This process yields reasonably good agreement between predicted and observed performance of the stone masonry walls for churches damaged during various earthquake events in Greece. Nonlinear 3-D numerical analyses are next employed for examining the performance of these unreinforced stone masonry churches. This is done by pushover inelastic numerical simulations, whereby the nonlinearities are concentrated in specific critical locations in an effort to simulate typical damage patterns that appear at the foundation-soil interface, at connection of masonry at the corner and at the roof level. Again, these pushover nonlinear numerical simulations seem to reproduce in a realistic way the observed damage patterns in these critical regions.
The Occurrence of Microplastics in Donax trunculus (Mollusca: Bivalvia) Collected along the Tuscany Coast (Mediterranean Sea)

Simple Summary Microplastics (MPs) are anthropogenic microscopic pieces of plastic in marine sediments and the water column that can originate from two different sources. Primary MPs are industrially produced microbeads, while secondary MPs result from the fragmentation of larger plastic debris by physical, chemical, and biological processes. Although not yet considered a food contaminant, they are readily ingested by marine organisms at several trophic levels, thus entering the food chain and representing a risk to consumers of fishery products. In this study, Donax trunculus (Truncate donax) specimens collected from Class A production areas in the Tyrrhenian Sea (Mediterranean Sea), and therefore destined directly for the final consumer, were analyzed for the presence of MPs. First, all items were morphologically classified and measured, and some of these were chemically identified. Then, the MPs’ mean abundance (MA) was calculated, and a risk assessment of human exposure to MPs was carried out. Both the MA of MPs and human exposure to MPs were found to be low. However, given the magnitude of the problem, the collection of further data using standardized methods is essential for a better risk assessment. Abstract Microplastics (MPs) (0.1 µm–5 mm particles) have been documented in oceans and seas. Bivalve molluscs (BMs) can accumulate MPs and transfer to humans through the food chain. BMs (especially mussels) are used to assess MPs’ contamination, but the genus Donax has not been thoroughly investigated. The aim of this study was to detect and characterize MPs in D. trunculus specimens collected along the Tuscan coast (Italy), and to assess the potential risk for consumers. The samples (~10 g of tissue and intervalval liquid from 35 specimens) were digested using a solution of 10% KOH, subjected to NaCl density separation, and filtered through 5 μm pore-size filters. All items were morphologically classified and measured, and their mean abundance (MA) was calculated. Furthermore, 20% of them were analyzed by Raman spectroscopy and, based on the obtained results, the MA was recalculated (corrected MA) and the annual human exposure was estimated. In the 39 samples analyzed, 85 items fibers (n = 45; 52.94%) and fragments (n = 40; 47.06%) were found. The MA was 0.23 ± 0.17 items/grww. Additionally, 83.33% of the items were confirmed as MPs (polyethylene and polyethylene terephthalate). Based on the correct MA (0.18 MPs/grww), D. trunculus consumers could be exposed to 19.2 MPs/per capita/year. The health risk level of MPs was classified as level III (moderate).