Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct and inverse results for popular differences in trees of positive dimension

Abstract We establish analogues for trees of results relating the density of a set ${E \subset \mathbb {N}}$ , the density of its set of popular differences and the structure of E. To obtain our results, we formalize a correspondence principle of Furstenberg and Weiss which relates combinatorial data on a tree to the dynamics of a Markov process. Our main tools are Kneser-type inverse theorems for sets of return times in measure-preserving systems. In the ergodic setting, we use a recent result of the first author with Björklund and Shkredov and a stability-type extension (proved jointly with Shkredov); we also prove a new result for non-ergodic systems.
Stochastic Thermodynamics of Non-Linear Electronic Circuits:A Realistic Framework for Thermodynamics of Computation

We present a general formalism for the construction of thermodynamically consistent stochastic models of non-linear electronic circuits. The devices constituting the circuit can have arbitrary I-V curves and may include tunnel junctions, diodes, and MOS transistors in subthreshold operation, among others. We provide a full analysis of the stochastic non-equilibrium thermodynamics of these models, identifying the relevant thermodynamic potentials, characterizing the different contributions to the irreversible entropy production, and obtaining different fluctuation theorems. Our work provides a realistic framework to study thermodynamics of computing with electronic circuits. We demonstrate this point by constructing a stochastic model of a CMOS inverter. We find that a deterministic analysis is only compatible with the assumption of equilibrium fluctuations, and analyze how the non-equilibrium fluctuations induce deviations from its deterministic transfer function. Finally, building on the CMOS inverter, we propose a full-CMOS design for a probabilistic bit (or binary stochastic neuron) exploiting intrinsic noise.
Noncommutative Tensor Triangular Geometry and the Tensor Product Property for Support Maps

The problem of whether the cohomological support map of a finite dimensional Hopf algebra has the tensor product property has attracted a lot of attention following the earlier developments on representations of finite group schemes. Many authors have focused on concrete situations where positive and negative results have been obtained by direct arguments. In this paper we demonstrate that it is natural to study questions involving the tensor product property in the broader setting of a monoidal triangulated category. We give an intrinsic characterization by proving that the tensor product property for the universal support datum is equivalent to complete primeness of the categorical spectrum. From these results one obtains information for other support data, including the cohomological one. Two theorems are proved giving compete primeness and non-complete primeness in certain general settings. As an illustration of the methods, we give a proof of a recent conjecture of Negron and Pevtsova on the tensor product property for the cohomological support maps for the small quantum Borel algebras for all complex simple Lie algebras.
Linear and superlinear spread for continuous-time frog model

Consider a stochastic growth model on $\mathbb{Z} ^\rm{d}$. Start with some active particle at the origin and sleeping particles elsewhere. The initial number of particles at $x \in \mathbb{Z} ^\rm{d}$ is $\eta(x)$, where $\eta (x)$ are independent random variables distributed according to $\mu$. Active particles perform a simple continuous-time random walk while sleeping particles stay put until the first arrival of an active particle to their location. Upon the arrival all sleeping particles at the site activate at once and start moving according to their own simple random walks. The aim of this paper is to give conditions on $\mu$ under which the spread of the process is linear or faster than linear. The main technique is comparison with other stochastic growth models.
ANTIMICROBIAL RESISTANCE IN ENTEROBACTERIACEAE FROM INTENSIVELY-REARED APPARENTLY HEALTHY AND DISEASED POULTRY IN ABEOKUTA, NIGERIA

The emergence and wide-spread dissemination of antimicrobial resistant bacteria strains is a global phenomenon of great public health and economic implications. Antimicrobial resistance was investigated in enterobacteriaceae isolated from apparently healthy and diseased poultry birds using the broth micro-dilution method to determine antimicrobial minimum inhibitory concentration (MIC). In all, 504 bacterial isolates including Escherichia coli (471), Klebsiella spp (28) and Salmonella enterica isolates (5) were studied. The isolates were resistant to ampicillin (88.5%), chloramphenicol (62.3%), ciprofloxacin (74.8%), enrofloxacin (81.0%), neomycin (83.9%), norfloxacin (78.8%), streptomycin (91.3%) and tetracycline (83.3%). The geometric mean MIC (µg/µL) of tested antimicrobials for enterobacteriaceae is as follows: ampicillin (102.5), chloramphenicol (48.4), ciprofloxacin (19.1), enrofloxacin (34.5), neomycin (47.7), norfloxacin (24.5), streptomycin (142.2) and tetracycline (62.5). Although rates of resistance to ampillin, streptomycin and tetracycline were similar among isolates from apparently healthy and diseases birds, resistance to chloramphenicol, ciprofloxacin, enrofloxacin, neomycin and norfloxacin were significantly higher (p<0.05) in isolates from diseased chickens than in those from apparently healthy chickens. The high rates of antimicrobial resistance in bacteria may contribute to the persistence of pathogens in poultry flock and ineffectiveness of antimicrobial chemotherapy during disease outbreaks.
Mechanisms by which the IKK-related Kinases Affect Energy Expenditure.

The IKK family of proteins has been linked to insulin resistance. In this chapter, we explore the effect on IKKε and TBK1 on metabolism, especially in adipose tissue. High fat diet increased IKKε and TBK1 protein levels in adipose tissue. Genetic ablation of IKKε or pharmacologic inhibition of IKKε and TBK1, using the selective inhibitor amlexanox, in mice resulted in many metabolic improvements, including reduced weight gain on a high-fat diet. These improvements were correlated with increased energy expenditure, core body temperature, adipocyte hyperplasia, and UCP1 protein levels in adipose tissue. Inhibitors of IKKε and TBK1 promote lipid accumulation and adipocyte proliferation in 3T3-L1 adipocyte differentiation. Treating 3T3-L1 adipocytes with amlexanox produced a dose-dependent increase in lipolysis and oxygen consumption. These studies suggested that IKKε and TBK1 diminish β-adrenergic/cAMP-dependent processes in adipocytes to regulate energy expenditure. Introduction The innate immune system has evolved to combat viral, bacterial, and other infectious challenges. It is also stimulated by noninfectious sources to promote chronic
Beta-catenin complexes in colorectal cancer

Genetic mutations that initiate and drive the progression of colorectal cancer cause defects in key signalling pathways that affect cell function. The Wnt signalling pathway is a key pathway that is disrupted in colorect catenin is a multifunctional protein with roles in Wnt signalling and cell adhesion. I aimed to -catenin. Specifica -catenin, decreases in APC, E-cadherin -catenin and cell behaviour. I established that mutant, non-catenin can be sequestered by APC and is less available for binding to and stabilising E-cadherin than wild-catenin, which only -catenin/E-cadherin protein complex, -catenin/APC complex also localises to the plasma membrane and cultured cells and tissue organoids. I also established a direct role for APC in directed cell migration that was independent of other genetic changes commonly found in colorectal cancer, including loss of PTEN, which on its own increased migration. To compare results from a cell culture to the situation in human tumours, -catenin was measured in adenomatous and serrated human colorectal polyps. -catenin was the plasma membrane, even in polyps with a serrated histology and reduced PTEN signals. However, the changes in E-cadherin observed in cultured cells lacking PTEN were not reproduced in these tumours. I also discovered that changes in transcription did not always mirror changes in protein expression, suggesting a -catenin than expected. Together, my data reveal that the distribution of -catenin between its main functions as an adhesion or transcriptional regulator, cannot be predicted by t XIV catenin alone, but is affected by many other signalling pathways that are frequently disregulated in cancer.
Factors associated with nonadherence to antihypertensive medication among middle-aged adults with hypertension: findings from the Taiwan National Health Interview Survey

Objective We aimed to investigate factors associated with nonadherence to antihypertensive medication among middle-aged Taiwanese adults with hypertension. Methods We used data from the 2009 Taiwan National Health Interview Survey (NHIS) to identify adults age 40 to 65 years with hypertension. We used logistic regression analyses to investigate factors associated with nonadherence to antihypertensive medication. Results A total 1,256 respondents with hypertension taking antihypertensive medication were included in this study. Multiple logistic regression analyses revealed that six factors were significantly and independently associated with nonadherence to medication: younger age (odds ratio, [OR] = 1.85), mean monthly personal income < TWD 20,000 (USD 660) (OR = 1.87), outpatient medical services use in the past month (OR = 0.57), hospitalization in the past year (OR = 1.70), diabetes or dyslipidemia (OR = 0.63), and alcohol use in the past month (OR = 2.38). Conclusions This secondary data analysis of the population-based NHIS identified six factors associated with nonadherence to antihypertensive medication. These factors should be considered when planning and implementing blood pressure control interventions among middle-aged adults with hypertension.
The Effectiveness of Leaflets and Posters as a Health Education Method

Introduction: Health education is a process of acquiring knowledge and skills in order to improve the health of the individual and the community. It is considered the most effective, most economical and most rational aspect of health care and health culture. Aim To provide data on the effectiveness of printed health-educational materials. Methods This is a quantitative, applied, descriptive-analytical study. According to the type of research, it presents a public health evaluation manipulative study with triple testing. The research was conducted in elementary schools in the Zenica-Doboj Canton. The total number of students participating in the research is divided into groups: examined, control group. The research consisted of four phases. The research tool is a modified questionnaire The Health Behavior in School-aged Children (HBSC) with 38 questions, 8 modules. Results The total number of respondents was 120. The method of distribution of health-educational posters shows a lower but still present statistical significance (p<0.05) in relation to the acquired knowledge and a change in attitudes between the conducted surveys at different time points. There is no statistically significant change (p>0.05) in the level of knowledge and attitudes using leaflets between conducted surveys at three different times. In the control group without education, there was a low statistical significance (p<0.05) in terms of changing the level of knowledge and attitudes. Conclusion The distribution of health-educational posters is recommended in situations where it is necessary to reach a wide audience for a long period of time, if the site of the poster is protected. According to this study, there is no evidence that the leaflet distribution method should be used when it comes to the promotion of healthy lifestyles among healthy children. Alternative methods and ways of health education need to be identified.
Intrathoracic Major Vessels, Trachea and Main Bronchi: The Effect of Respiration on Size

Purpose : To evaluate the effect of respiration on the sizes of intrathoracic vasculature, and the trachea, and the main bronchus. Materials and Methods : Seventeen volunteers (10 males aged 20 39 years and 7 females aged 20 39 years) underwent spiral CT, between the apex and lowest base ofthe lung, collimation was 10 mm, pitch was 1, and images were obtained at breath hold forced end-inspiration and breath hold forced end-expiration. Cross secional areas or diameters were measured in each respiration state at the aorta (ascending, descending , lower thoracic) and great branches, the IVC (thoracic, abdominal), the SVC, pulmonary artery (right main, left descending) and the tracheobronchus (trachea, left upper bronchus). Changes in the size ofvessels and airways between the respiration states were evaluated and compared between inspiration and expiration. Results : During breath-hold forced end-inspiration CT, the ascending, descending, and lower thoracic aorta and its branches (brachiocephalic, left common carotid , left subclavian) as well as the thoracic IVC and SVC and the right main and left descending pulmonary arteries decreased in size : during breath-hold forced end-expiration CT, the size of all these vessels increased. For the trachea, left up per lobe bronchus and abdominal IVC , the situation was reversed. Statistically sig nificant changes(p < 0.05) were noted in the ascending aorta and descending aorta, the lower thoracic aorta, the thoracic and abdominal IVC , the SVC, the right main and left pulmonary arteries, and the trachea. Conclusion : During respiration, changes in the size of the thoracic vasculature and airways is probably due to changes in intrathoracic pressure. In the measurement and diagnosis of stenosis or dilatation in the intrathoracic vesculature and airways, respiration states should therefore be considered.
Does Water, Waste, and Energy Consumption Influence Firm Performance? Panel Data Evidence from S&P 500 Information Technology Sector

This paper aimed to investigate the impact of water, waste, and energy consumption on firm performance for a sample of enterprises that belong to the S&P 500 Information Technology sector over the period of 2009–2020. The quantitative framework covered both accounting (e.g., return on assets—ROA; return on common equity—ROE; return on capital—ROC; return on invested capital—ROIC) and market-based measures of performance (e.g., price-to-book value—PB), alongside firm and corporate governance specific variables. By estimating multivariate panel data regression models, the empirical results provided support for a negative impact of total water use on PB but a positive effect on ROA. With reference to the total waste, the econometric outcomes revealed a negative influence on the entire selected performance measures, whereas total energy consumption did not reveal any statistically significant influence.
Investigating the Vascular Toxicity Outcomes of the Irreversible Proteasome Inhibitor Carfilzomib

Background: Carfilzomib’s (Cfz) adverse events in myeloma patients include cardiovascular toxicity. Since carfilzomib’s vascular effects are elusive, we investigated the vascular outcomes of carfilzomib and metformin (Met) coadministration. Methods: Mice received: (i) saline; (ii) Cfz; (iii) Met; (iv) Cfz+Met for two consecutive (acute) or six alternate days (subacute protocol). Leucocyte-derived reactive oxygen species (ROS) and serum NOx levels were determined and aortas underwent vascular and molecular analyses. Mechanistic experiments were recapitulated in aged mice who received similar treatment to young animals. Primary murine (prmVSMCs) and aged human aortic smooth muscle cells (HAoSMCs) underwent Cfz, Met and Cfz+Met treatment and viability, metabolic flux and p53-LC3-B expression were measured. Experiments were recapitulated in AngII, CoCl2 and high-glucose stimulated HAoSMCs. Results: Acutely, carfilzomib alone led to vascular hypo-contraction and increased ROS release. Subacutely, carfilzomib increased ROS release without vascular manifestations. Cfz+Met increased PGF2α-vasoconstriction and LC3-B-dependent autophagy in both young and aged mice. In vitro, Cfz+Met led to cytotoxicity and autophagy, while Met and Cfz+Met shifted cellular metabolism. Conclusion: Carfilzomib induces a transient vascular impairment and oxidative burst. Cfz+Met increased vascular contractility and synergistically induced autophagy in all settings. Therefore, carfilzomib cannot be accredited for a permanent vascular dysfunction, while Cfz+Met exert vasoprotective potency.
Comprehensive review of hemolysis in ventricular assist devices

Ventricular assist devices (VADs) have played an important role in altering the natural history of end-stage heart failure. Low-grade hemolysis has been traditionally described in patients with VADs, indicating effective device functionality. However, clinically significant hemolysis could be crucial in terms of prognosis, calling for prompt therapeutic actions. The absence of solid and widely approved diagnostic criteria for clinically significant hemolysis, render the utilization of hemolysis laboratory markers challenging. Hemolysis incidence varies (5%-18%) depending on definition and among different VAD generations, being slightly higher in continuous-flow devices than in pulsatile devices. Increased shear stress of red blood cells and underlying device thrombosis appear to be the main pathogenetic pathways. No certain algorithm is available for the management of hemolysis in patients with VADs, while close clinical and laboratory monitoring remains the cornerstone of management. Imaging examinations such as echocardiography ramp test or computed tomography scan could play a role in revealing the underlying cause. Treatment should be strictly personalized, including either pharmacological (antithrombotic treatment) or surgical interventions.
The Study Demands-Resources Framework: An Empirical Introduction

Based on the well-established job demands-resources (JD-R) framework, in our study we introduce the novel study demands-resources (SD-R) framework. The SD-R framework allows the study of salutogenic and pathogenic effects of university settings on students’ health and well-being. Using a large sample of university students (n = 5660), our aim was to translate and validate the JD-R’s essential assumptions within the university context, and thus establish the SD-R framework. We performed structural equation modelling to examine these essential assumptions. As assumed, we found that study demands—the “bad things” at university—predict student burnout (β = 0.50), whereas study resources—the “good things” at university—predict student engagement (β = 0.70) as well as burnout (β = −0.35). Also, in line with the SD-R’s assumptions, student burnout predicts life satisfaction negatively (β = −0.34), whereas student engagement predicts life satisfaction positively (β = 0.29). Hence, we were able to introduce the novel SD-R framework and validate its core assumptions. The SD-R framework serves as an excellent theoretical basis to examine both the salutogenic and pathogenic effects of the study context on students’ health and well-being. However, the framework needs further longitudinal and meta-analytical verification in accordance with the research on the JD-R framework.
Health Risk Assessment of Dietary Heavy Metals Intake from Fruits and Vegetables Grown in Selected Old Mining Areas—A Case Study: The Banat Area of Southern Carpathians

In this study, we conducted a noncarcinogenic risk assessment of consuming vegetables and fruits grown in two old mining areas from the Banat area of Southern Carpathians (Romania), Moldova Veche (M) and Rusca Montana (R) and in a nonpolluted reference area located near the village of Borlova (Ref). Concentrations of Fe, Mn, Zn, Cu, Ni, Cd and Pb in soils and commonly eaten vegetables and fruits were measured and used for calculating the weighted estimated daily intake of metals (WEDIM), the target hazard quotients (THQ) and the total target hazard quotients (TTHQ) for normal daily consumption in adults. Levels of certain metals in soils and plants from the R area (Pb) and the M area (Cu) were higher than those measured in the Ref area—and often exceeded normal or even alert-threshold levels. TTHQs for the R area (1.60; 6.03) and the M area (1.11; 2.54) were above one for leafy vegetables and root vegetables, respectively, suggesting a major risk of adverse health effects for diets, including these vegetal foodstuffs. Moreover, THQ and TTHQ indicated a higher population health risk for the R area than for the M area, with the Ref area being a safe zone.
Effect of the Coronavirus Disease 2019 (COVID-19) Pandemic on Pediatric Resident Well-Being

Objectives: This study aims to identify factors specific to the COVID-19 pandemic that affect resident physicians’ well-being, identify potential sources of anxiety, and assess for depression and stress among residents. Methods: A cross-sectional survey was performed in April 2020 that evaluated resident perceptions about COVID-19 pandemic, its impact on their personal lifestyle, and coping mechanisms adopted. The respondents also completed the Beck Depression Inventory-II (BDI-II) and Cohen Perceived Stress Scale (PSS-10). Results: Of 37 residents, 29 completed the survey for a response rate of 78%. We found that 50% of residents harbored increased anxiety due to the pandemic and reported fears of spreading disease. Factors that negatively impacted their well-being included social isolation from colleagues (78%), inability to engage in outdoor activities (82%), and social gatherings (86%). Residents expressed concern about the effect of the COVID-19 pandemic on their didactic education and clinical rotations. The mean PSS-10 total score was 17 (SD = 4.96, range = 0-33) and the mean BDI-II total score was 6.79 (SD = 6.00). Our residents adopted a number of coping mechanisms in response to COVID-19. Conclusions: We identified factors specific to the COVID-19 pandemic that adversely affected resident physician well-being. Trainees were concerned about the risk of developing COVID-19 and spreading this to their family. Residents also harbored anxiety regarding the effect of COVID-19 on their education. Lifestyle changes including social isolation also resulted in a negative effect on resident well-being. Developing strategies and resources directed to addressing these concerns may help support well-being and alleviate stress and anxiety.
Dissociable Effects of Executive Load on Perceived Exertion and Emotional Valence during Submaximal Cycling

Endurance physical exercise is accompanied by subjective perceptions of exertion (reported perceived exertion, RPE), emotional valence, and arousal. These constructs have been hypothesized to serve as the basis for the exerciser to make decisions regarding when to stop, how to regulate pace, and whether or not to exercise again. In dual physical-cognitive tasks, the mental (executive) workload generated by the cognitive task has been shown to influence these perceptions, in ways that could also influence exercise-related decisions. In the present work, we intend to replicate and extend previous findings that manipulating the amount of executive load imposed by a mental task, performed concomitantly with a submaximal cycling session, influenced emotional states but not perceived exertion. Participants (experienced triathletes) were asked to perform a submaximal cycling task in two conditions with different executive demands (a two-back version of the n-back task vs. oddball) but equated in external physical load. Results showed that the higher executive load condition elicited more arousal and less positive valence than the lower load condition. However, both conditions did not differ in RPE. This experimental dissociation suggests that perceived exertion and its emotional correlates are not interchangeable, which opens the possibility that they could play different roles in exercise-related decision-making.