Miracle-dz/UniFAR-FTUs huggingface dataset:
The influence of COVID-19 on agricultural economy and emergency mitigation measures in China: A text mining analysis

Understanding the influence of COVID-19 on China's agricultural economy and the Chinese government's emergency measures to ease the economic impacts of viral spread can offer urgently-needed lessons while this virus continues to spread across the globe. Thus, this study collected over 750,000 words upon the topic of COVID-19 and agriculture from the largest two media channels in China: WeChat and Sina Weibo, and employed web crawler technology and text mining method to explore the influence of COVID-19 on agricultural economy and mitigation measures in China. The results show that: (1) the impact of COVID-19 on China's agricultural economy at the very first phase is mainly reflected in eight aspects as crop production, agricultural products supply, livestock production, farmers' income and employment, economic crop development, agricultural products sales model, leisure agriculture development, and agricultural products trade. (2) The government's immediate countermeasures include resuming agricultural production and farmers' work, providing financial support, stabilizing agricultural production and products supply, promoting agricultural products sale, providing subsidies, providing agricultural technology guidance and field management, and providing assistance to poor farmers to reduce poverty. (3) The order of government's immediate countermeasures is not all in line with the order of impact aspects, which indicates that more-tailored policies should be implemented to mitigate the strikes of COVID-19 on China's agricultural economy in the future.
An African Savanna: Synthesis of the Nylsvley Study.

Preface Part I. Nylsvley: An African Savanna: 1. African savannas 2. The people of Nylsvley 3. The climate of Nylsvley 4. Geology, landform and soils 5. The Nylsvley biota Part II. The Key Determinants: Water, Nutrients, Fire, and Herbivory: 6. Water 7. Nutrients 8. Fire 9. Herbivory Part III. The Carbon Cycle: 10. Primary production 11. Decomposition Part IV. Community and Landscape Pattern and Change: 12. Rich savanna, poor savanna 13. Community structure, composition and dynamics 14. Tree-grass interactions 15. Plant-animal interactions Part V. Lessons From Nylsvley: 16. An overview of savanna ecology 17. Managing savannas 18. Reflections on ecosystem studies References Index.
Key performance indicators at FIFA Women's World Cup in different playing surfaces

The aim of this study was to examine the key performance indicators of female professional soccer players during the 2011 and 2015 FIFA Women's World Cup, played on different surfaces (natural and artificial turf respectively). A total of 438 women from 24 national teams who participated at Canada 2015 (artificial turf) and 283 players from 16 national teams who played in Germany 2011 (natural grass) were selected for this study. The collected data were provided by OPTA Sports. Twenty-nine key performance indicators were included for analysis. The variables were calculated for the total sample and independently by positions (defense, midfielders and forwards) for matches on natural grass (2011) and artificial turf (2015). A Mann–Whitney U test was used out to identify differences between the sport surfaces. Moreover, a discriminant analysis was performed with the forced entry method to find the variables that better differentiated between the FIFA Women's World Cup 2011 (natural grass) and FIFA Women's World Cup 2015 (artificial turf). Key performance aspects were very similar between the two tournaments, but on natural grass, we observed a significantly higher number of total passes, successful dribbles, total tackles, successful tackles and interceptions. However, on artificial turf there were significantly higher percentages of success in total passes, and a higher number of fouls. This is an important factor for the choice of an elite competition surface because technical actions are crucial to the quality of the game and can influence the future behavior of spectators and fans.
Perfluorooctane Sulfonate (PFOS) and Perfluorohexane Sulfonate (PFHxS) Alters Protein Phosphorylation, Increase ROS Levels and DNA Fragmentation during In Vitro Capacitation of Boar Spermatozoa

Simple Summary Perfluorinated compounds are synthetic chemicals, with a wide variety of applications like firefighting foams, food packaging, additives in paper and fabrics to avoid dyes. Perfluorooctane sulfonate and perfluorohexane sulfonate are globally distributed, and contaminates air, water, food, and dust, have toxic effects and bioaccumulate. Significant levels of these compounds have found in blood serum, breast milk, and semen of occupationally exposed and unexposed people, as well as in blood serum and organs of the domestic, farm, and wild animals. The present study seeks to analyze the toxic effects and possible alterations caused by the presence of these compounds in boar sperm during the in vitro capacitation, due to their toxicity, worldwide distribution, and lack of information in spermatozoa physiology during pre-fertilization processes. Abstract Perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) are toxic and bioaccumulative, included in the Stockholm Convention’s list as persistent organic pollutants. Due to their toxicity, worldwide distribution, and lack of information in spermatozoa physiology during pre-fertilization processes, the present study seeks to analyze the toxic effects and possible alterations caused by the presence of these compounds in boar sperm during the in vitro capacitation. The spermatozoa capacitation was performed in supplemented TALP-Hepes media and mean lethal concentration values of 460.55 μM for PFOS, and 1930.60 μM for PFHxS were obtained. Results by chlortetracycline staining showed that intracellular Ca2+ patterns bound to membrane proteins were scarcely affected by PFOS. The spontaneous acrosome reaction determined by FITC-PNA was significantly reduced by PFOS and slightly increased by PFHxS. Both toxic compounds significantly alter the normal capacitation process from 30 min of exposure. An increase in ROS production was observed by flow cytometry and considerable DNA fragmentation by the comet assay. The immunocytochemistry showed a decrease of tyrosine phosphorylation in proteins of the equatorial and acrosomal zone of the spermatozoa head. In conclusion, PFOS and PFHxS have toxic effects on the sperm, causing mortality and altering vital parameters for proper sperm capacitation.
Association of Insufficient or Excess Sleep with Type 2 Diabetes Mellitus in the Presence of Periodontitis

We aimed to investigate the effects of sleep duration on impaired fasting glucose and diabetes in Korean adults with periodontal disease. This cross-sectional study was performed using data for 10,465 subjects aged >19 years who completed the periodontal examination and questionnaires in the Sixth Korea National Health and Nutrition Examination Survey (2013–2015). The effect of sleep was confirmed by a complex-sample multinomial logistic regression analysis. Confounding variables were age, sex, household income, education level, smoking status, and sleep duration. Of all participants, 25.7% had periodontitis, of which 28.6% had fasting serum glucose disorder and 14.2% had diabetes. Among participants with periodontitis, the prevalence of diabetes was 1.49 times higher in participants with an average sleep duration of ≥8 h than those with an average sleep duration of 6–7 h. The prevalence of diabetes among participants without periodontitis was 1.49 times and 1.57 times higher in participants with an average sleep duration of ≤5 and ≥8 h, respectively, than those with an average sleep duration of 6–7 h. We found that altered sleep duration may be a risk factor for diabetes and that proper sleep duration is important to control diabetes incidence.
The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening thrombotic microangiopathy caused by severe ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs 13) deficiency, recurring in 30–50% of patients. The common human leukocyte antigen (HLA) variant rs6903608 was found to be associated with prevalent iTTP, but whether this variant is associated with disease relapse is unknown. To estimate the impact of rs6903608 on iTTP onset and relapse, we performed a case-control and cohort study in 161 Italian patients with a first iTTP episode between 2002 and 2018, and in 456 Italian controls. Variation in rs6903608 was strongly associated with iTTP onset (homozygotes odds ratio (OR) 4.68 (95% confidence interval (CI) 2.67 to 8.23); heterozygotes OR 1.64 (95%CI 0.95 to 2.83)), which occurred over three years earlier for each extra risk allele (β −3.34, 95%CI −6.69 to 0.02). Of 153 survivors (median follow-up 4.9 years (95%CI 3.7 to 6.1)), 44 (29%) relapsed. The risk allele homozygotes had a 46% (95%CI 36 to 57%) absolute risk of relapse by year 6, which was significantly higher than both heterozygotes (22% (95%CI 16 to 29%)) and reference allele homozygotes (30% (95%CI 23 to 39%)). In conclusion, HLA variant rs6903608 is a risk factor for both iTTP onset and relapse. This newly identified biomarker may help with recognizing patients at high risk of relapse, who would benefit from close monitoring or intensified immunosuppressive therapy.
Intraoperative Mother and Baby Skin-to-Skin Contact during Cesarean Birth: Systematic Review.

PURPOSE Experts recommend immediate skin-to-skin (SSC) contact for all alert and stable mothers and newborns after birth. Clinicians are working to incorporate immediate (intraoperative) SSC during cesarean birth. The purpose of this systematic review is to describe the state of the science of intraoperative SSC for mother and baby and increase clinician's awareness of its potential benefits and risks. STUDY DESIGN AND METHODS A systematic approach was followed throughout the review process. CINAHL, PubMed, and Embase databases were searched using strategies constructed by an academic health sciences librarian. Articles included in the review focused on SSC initiated during cesarean birth. RESULTS Thirteen studies were selected for the mixed-method systematic review. Six prospective studies, four retrospective chart reviews, and three qualitative studies met the inclusion criteria. Maternal stress levels were reduced, whereas comfort, oxytocin, and antioxidant levels increased with intraoperative SSC. Physiologic measures of successful newborn transition showed little difference between newborns held in intraoperative SSC and those who were not. Synthesis of qualitative experiences revealed mothers' intense desire to hold and know their baby immediately after birth. CLINICAL IMPLICATIONS Intraoperative SSC is a safe, beneficial, and highly desirable practice for mothers and newborns experiencing cesarean birth. Although barriers exist to its implementation, nurses can facilitate and support this practice. Evidence-based, family-centered intraoperative SSC should be offered to all stable mothers and babies according to recommendations and in a manner that promotes safe outcomes, including following current nurse staffing guidelines.
Characterization and Genetic Variability of Indian Mustard Genotypes for Branching Behavior, Yield and Its Attributes under Rainfed Condition

Mustard has been grown in the Indian subcontinent as an oilseed crop. Brassica species are one of the major oilseed crops of the world (Md. Mukhlesur et al., 2004). It is the second largest oilseed crop in India after groundnut. Indian mustard (Brassica juncea L.), locally called as Laha, Raya or Rai, belongs to family Cruciferae; genus Brassica (Iraddi, 2008) and introduced as an oily herb, which is appropriate for zones with short seasons and less rainfall (Burton et al., 1999). It is cultivated in winter season and is a thermo as International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 06 (2018) Journal homepage: http://www.ijcmas. com
Identification of new genetic alterations and potential biomarkers in papillary thyroid carcinoma

(ENGLISH) 4 ABSTRACT (ITALIANO) 6 (ITALIANO) 6 1 INTRODUCTION 9 1.1 CANCER GENETICS 10 1.1.1 PROTO-ONCOGENES AND ONCOGENES 10 1.1.2 TUMOR SUPPRESSOR GENES 11 1.1.3 DNA REPAIR 12 1.1.4 CELL CYCLE 13 1.1. 5 MUTATION TIMING AND DRIVER GENES 15 1.1. 6 SIGNALING PATHWAYS IN TUMORS 16 1.2 THYROID CARCINOMA 17 1.2. 1 PAPILLARY THYROID CARCINOMA 20 1.2. 2 MOLECULAR GENETICS ALTERATION IN PAPILLARY THYROID CARCINOMA 22 1.3 RNA-SEQUENCING 26 1.3.1 ILLUMINA SEQUENCING TECHNOLOGY 28 1.3.2 RNA-SEQUENCING DATA ANALYSIS 30 1.3.3 RNA-SEQ IN PAPILLARY THYROID CARCINOMA 32 1.4. LONG NON CODING RNAS 33 1.4. 1 FUNCTIONS AND MECHANISMS OF LNCRNAS 35 1.4. 2 METHODS TO DISCOVER LNCRNAS 40 1.4. 3 LNCRNA AND CANCER 42 1.4. 4 ONCOGENIC LONG NON CODING RNAS 43 1.4. 5 TUMOR-SUPPRESSOR NCRNAS 46 1.4. 6 LNCRNAS AND PAPILLARY THYROID CANCER 48 2 PRINCIPAL AIM OF THE PROJECT 50 3. IDENTIFICATION OF NEW SOMATIC MUTATIONS AND WNK1-­‐B4GALNT3 GENE FUSION IN PAPILLARY THYROID CARCINOMA 53 3.1 METHODS 54 3.1.1 PATIENTS AND RNA SAMPLES PREPARATION 54 3.1.2 LIBRARY PREPARATION AND RNA-SEQUENCING DATA ANALYSIS 54 3.1.3 ANALYSIS OF SINGLE NUCLEOTIDE VARIANTS 56 3.1.4 ANALYSIS OF FUSION TRANSCRIPTS 58 3.1. 5 REVERSE TRANSCRIPTION 58 3.1. 6 RT-PCR ASSAY, CLONING AND SANGER SEQUENCING 59 3.2 RESULTS 61 3.2. 1.ANALYSIS OF KNOWN DRIVER PTC ALTERATIONS 61 3.2. 2 SINGLE NUCLEOTIDE VARIANTS IN CANCER DRIVER GENES 64 3.2. 3 IDENTIFICATION OF NEW MUTATIONS IN PTC 66 3.2. 4 IN SILICO ANALYSIS OF NEWLY IDENTIFIED MUTATIONS 68 3.2. 5 WNK1-B4GALNT3: IDENTIFICATION OF A NOVEL GENE FUSION 70 3.2. 6 WNK1-B4GALNT3 IN COLON CANCER SAMPLE 74 3.3 DISCUSSION 75 4 GENOME-­‐WIDE ANALYSIS OF LNCRNAS INVOLVED IN PAPILLARY THYROID CARCINOMA 78
Heterozygous APOE Christchurch in familial Alzheimer’s disease without mutations in other Mendelian genes

A rare APOE variant, named APOE3 Christchurch (APOEch) [1], yielding a missense mutation from Arginine to Serine at amino acid 136 (corresponding to codon 154), has been recently found in some members of a large Colombian kindred with autosomal dominant Alzheimer's disease (ADAD) due to an E280A mutation in PSEN1 [2]. The authors described a woman homozygous for the APOEch, who did not develop mild cognitive impairment (MCI) until her seventies, almost 30 years after the typical age of onset related to the PSEN1 mutation [3].
Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response

We developed a mathematical model to predict the outcomes of different possible COVID-19 treatments. To affect the COVID-19 pandemic, lifesaving antiviral therapies must be identified. The number of clinical trials that can be performed is limited. We developed mathematical models to project multiple therapeutic approaches. Our models recapitulate off-treatment viral dynamics and predict a three-phase immune response. Simulated treatment with remdesivir, selinexor, neutralizing antibodies, or cellular immunotherapy demonstrates that rapid viral elimination is possible if in vivo potency is sufficiently high. Therapies dosed soon after peak viral load when symptoms develop may decrease shedding duration and immune response intensity but have little effect on viral area under the curve (AUC), which is driven by high early viral loads. Potent therapy dosed before viral peak during presymptomatic infection could lower AUC. Drug resistance may emerge with a moderately potent agent dosed before viral peak. Our results support early treatment for COVID-19 if shedding duration, not AUC, is most predictive of clinical severity.
N-[2-(4-Acetyl-1-Piperazinyl)Phenyl]-2-(3-Methylphenoxy)Acetamide (NAPMA) Inhibits Osteoclast Differentiation and Protects against Ovariectomy-Induced Osteoporosis

Osteoclasts are large, multinucleated cells responsible for bone resorption and are induced in response to the regulatory activity of receptor activator of nuclear factor-kappa B ligand (RANKL). Excessive osteoclast activity causes pathological bone loss and destruction. Many studies have investigated molecules that specifically inhibit osteoclast activity by blocking RANKL signaling or bone resorption. In recent years, we screened compounds from commercial libraries to identify molecules capable of inhibiting RANKL-induced osteoclast differentiation. Consequently, we reported some compounds that are effective at attenuating osteoclast activity. In this study, we found that N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(3-methylphenoxy)acetamide (NAPMA) significantly inhibited the formation of multinucleated tartrate-resistant acid phosphatase (TRAP)-positive cells from bone marrow-derived macrophages in a dose-dependent manner, without cytotoxic effects. NAPMA downregulated the expression of osteoclast-specific markers, such as c-Fos, NFATc1, DC-STAMP, cathepsin K, and MMP-9, at the transcript and protein levels. Accordingly, bone resorption and actin ring formation were decreased in response to NAPMA treatment. Furthermore, we demonstrated the protective effect of NAPMA against ovariectomy-induced bone loss using micro-CT and histological analysis. Collectively, the results showed that NAPMA inhibited osteoclast differentiation and attenuated bone resorption. It is thus a potential drug candidate for the treatment of osteoporosis and other bone diseases associated with excessive bone resorption.
Agro-Morphological Characterization of Sicilian Chili Pepper Accessions for Ornamental Purposes

The species belonging to the genus Capsicum have been widely used as decorative vegetables, however only a few genotypes are available for this purpose. The goal of the present work was the agro-morphological characterization of several chili pepper accessions cultivated into different pot sizes (10, 14, 18 or 20 cm diameters). The agro-morphological characterization of 19 accessions was performed following IPGR (International Plant Genetic Resources Institute) descriptors: plant height (PH), plant canopy width (PCW), PH/PCW ratio, plant growth habit, plant visual quality, first flower emission, fruiting start, end of harvest, fruit number, fruit length, fruit width, fruit color at mature stage and fruit shape. Analysis of Variance (ANOVA) for all observed traits showed statistical significant differences among the genotypes tested. Results of the heat map complementarily secured the frequency of multiplicity highlighted from the ANOVA analysis. Furthermore, the present study pointed out that A33, A27, G1 and A1 chili pepper accessions achieved optimal performances in terms of plant visual quality, which is a crucial trait for ornamental purposes.
Post-traumatic stress, social, and physical health: A mediation and moderation analysis of Syrian refugees and Jordanians in a border community

Objectives This study examined the mediating or moderating relationship of social health on physical health and post-traumatic stress symptoms among displaced Syrians and Jordanians at high risk for physical and mental health ailments. Frequency of mental health symptoms stratified by demographic factors was also explored. We hypothesized social health would mediate and/or moderate the relationship between physical and post-traumatic stress symptoms (PTSS). Methods This cross-sectional study includes 598 adults between 18 and 75 years old recruited from three health centers in the city of Irbid, Jordan, 20 km away from the Syrian border. Post-traumatic stress symptoms (PTSS) were measured through the primary care post-traumatic stress disorder checklist. Physical and social health were assessed through the Duke Health Profile. One-way ANOVA and independent samples T-tests examined mean scores of social health, PTSS, physical health stratified by age, gender, nationality, education level, and trauma exposure. Bivariate correlations explored the relationship between social health, PTSS, and physical health. PROCESS macro tested social health as a moderator and mediator on the association of the physical health and PTSS. Results Social health moderated and mediated the relationship between physical health and PTSS. Males reported (t = 2.53, p < .05) better physical health scores than females. Those who had less than a high school education reported lower social health (F = 13.83, p < .001); higher PTSS (F = 5.83, p < .001); and lower physical health (F = 5.76, p < .01) than more educated individuals. Syrians reported significantly higher PTSS (F = 4.13, p < .05) than Jordanians, however, there was no significant differences between nationality for physical or social health. Social health was positively associated with better physical health (r = 0.10, p < .01) and negatively with PTSS (r = -.293, p < .01). Conclusions Our results support our primary hypothesis suggesting social health mediates and moderates PTSS and physical health. Secondary findings illustrate gender, educational, and income differences in physical health and PTSS. Clinical trials registry NCT03721848
Investigations on different Semen Extenders for Cockatiel Semen

The aim of the present study was the modification and evaluation of three different semen extenders for cockatiel semen in order to achieve a long survival time for transport, examination purpose and for potential cryopreservation, respectively. Therefore, individual and pooled semen samples of 30 cockatiels (Nymphicus hollandicus) were investigated for pH and osmolality values and subsequently pH and osmolality values of the semen extenders were adjusted to those values in the semen. Pooled semen samples were then partitioned into four equal parts and diluted with the three different semen extenders in 1:4 and 1:8 dilution. 1 % glucose-Ringer’s solution was used as control, respectively. A total of 64 incremental diluted semen samples were obtained for investigation. Each dilution was investigated regarding sperm motility immediately after dilution and another four times every 30 minutes. Sperm viability was evaluated 0 and 120 minutes after dilution via eosin B-stain on the diluted semen samples and in pure semen samples. Additionally, the fluorescence stain SYBR® Green/propidium iodide was used to assess sperm viability. The results indicate that cockatiel spermatozoa are highly sensitive to variations in pH and osmolality, requiring adjustment of commercial diluents to pH = 7.42 and osmolality = 300 mOsm/kg. Modified Lake diluent maintained higher viability and motility than other diluents tested. Sperm morphology was indicated to be least adversely affected by modified Lake diluent in 1:4 concentration compared to other semen extenders and concentrations used.