Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient Nano-Scale Design of TIEO Based Reversible Logic Toffoli Gate Priority Encoder in Quantum-Dot Cellular Automata

The goal of this research is to create a QCA-based reversible priority encoder. It is one of the most crucial parts of the encoding and decoding process. This novel nanotechnology, known as quantum-dot cellular automata (QCA), shows promise as a foundation for the development of reversible circuits. This paper proposes a simple, reversible, 4-2 line priority encoder design for the QCA platform. Using the simple and cheap Toffoli gate architecture, a reversible encoder circuit may be built. To analyze the proposed designs’ structural soundness, the simulation program QCA Designer is used.
Is It Time to Reconsider Rituximab Dosing Regimens for Pemphigus Vulgaris?

Rituximab is currently approved for patients affected by moderate-to-severe pemphigus vulgaris, a severe autoimmune blistering skin disease that can be life-threatening. The standard rituximab dosing regimens, originally established for B-cell non-Hodgkin’s lymphomas, have been recognized to exceed the effective dose required for inducing B-cell depletion, considering that the B-cell burden in pemphigus vulgaris is considerably lower than in lymphoproliferative disorders. We herein report our experience with very ultra-low-dose rituximab in two patients affected by pemphigus vulgaris.
Derivation and Internal Validation of a Mortality Prognostication Machine Learning Model in Ebola Virus Disease Based on Iterative Point-of-Care Biomarkers

Abstract Background Although multiple prognostic models exist for Ebola virus disease mortality, few incorporate biomarkers, and none has used longitudinal point-of-care serum testing throughout Ebola treatment center care. Methods This retrospective study evaluated adult patients with Ebola virus disease during the 10th outbreak in the Democratic Republic of Congo. Ebola virus cycle threshold (Ct; based on reverse transcriptase polymerase chain reaction) and point-of-care serum biomarker values were collected throughout Ebola treatment center care. Four iterative machine learning models were created for prognosis of mortality. The base model used age and admission Ct as predictors. Ct and biomarkers from treatment days 1 and 2, days 3 and 4, and days 5 and 6 associated with mortality were iteratively added to the model to yield mortality risk estimates. Receiver operating characteristic curves for each iteration provided period-specific areas under curve with 95% CIs. Results Of 310 cases positive for Ebola virus disease, mortality occurred in 46.5%. Biomarkers predictive of mortality were elevated creatinine kinase, aspartate aminotransferase, blood urea nitrogen (BUN), alanine aminotransferase, and potassium; low albumin during days 1 and 2; elevated C-reactive protein, BUN, and potassium during days 3 and 4; and elevated C-reactive protein and BUN during days 5 and 6. The area under curve substantially improved with each iteration: base model, 0.74 (95% CI, .69–.80); days 1 and 2, 0.84 (95% CI, .73–.94); days 3 and 4, 0.94 (95% CI, .88–1.0); and days 5 and 6, 0.96 (95% CI, .90–1.0). Conclusions This is the first study to utilize iterative point-of-care biomarkers to derive dynamic prognostic mortality models. This novel approach demonstrates that utilizing biomarkers drastically improved prognostication up to 6 days into patient care.
A Random-Walk Model For Pore Pressure Accumulation In Marine Soils

A numerical random-walk model has been developed for the pore-water pressure. The model is based on the analogy between the variation of the pore pressure and the diffusion process of any passive quantity such as concentration. The pore pressure in the former process is analogous to the concentration in the latter. In the simulation, particles are released in the soil, and followed as they travel through the statistical field variables. The model has been validated (1) against the Terzaghi consolidation process, and (2) against the process where the pore pressure builds up under progressive waves. The model will apparently enable the researcher to handle complex geometries (such as a pipeline buried in a soil) relatively easily. Early results with regard to the latter example, namely the buildup of pore pressure around a buried pipeline subject to a progressive wave, are encouraging.
Effect of Intra-Thoracic Oscillations on Blood Gases after Coronary Artery Bypass Graft Surgery

Article information Background: Coronary artery disease] CAD [causes significant respiratory, medical, and physical problems affecting the quality of life [QoL [. Quake device, one of the oscillatory positive expiratory pressure [OPEP] family, may improve the health of patients with CAD, but more research is needed. The Aim of the work: The main aim of this study was to examine the effects of intra-thoracic oscillations on blood gases after coronary artery bypass graft surgery [CABG]. Patients and Methods: The research included a cohort of 60 male individuals who had the surgical procedure known as Coronary Artery Bypass Grafting [CABG] aged 55 – 65; they were recruited from the 6 October hospital. The patients were divided equally into groups A and B; group A included patients who underwent therapy with OPEP using the Quake device in conjunction with conventional and medically recommended therapies; group B included patients treated by traditional treatment and their prescribed medical treatment. Both treatments were performed once daily from the first day till the seventh day after operation. They were evaluated using Arterial Blood Gases [ABG], the sit-to-stand test, and the [SF-36] QoL questionnaire. Results: The previous and post-study comparison revealed a significant enhancement in both groups of ABG values [PH, PaO 2 , PaCO 2 , and HCO 3 ] and, the sit-to-stand test and SF-36 questionnaire. The study group had a statistically significant advantage over the control group when comparing all assessed post-treatment parameters to those of the control group. Conclusion: Early rehabilitation after CABG surgery via Quake device could improve ABG, patient's functional capacity,reflecting a better QoL.
Fusulinids from the Cyathophyllum Limestone, Central Vestspitsbergen

Thirteen species of fusulinids are illustrated and de­ scribed from eleven collections within the Cyathophyllum Limestone of central Vestspitsbergen. The lower collec­ tions at Tempelfjorden and the collection from Mount Lykta contain Schubertella transitoria, Triticites arcticus. and Schwageriiia anderssoni and other species typical of the Carboniferous zones C^C through CgE of the Ural region of the U.S.S.R. It is suggested that “Fusulinella'* usvae is a species of Waeringella. Higher collections at Tempelfjorden include Parafusulina furnishi n. sp. and Pseudofusulinella teinpeleiisis n. sp. and a loose block from higher in the succession includes Schwagerina globosa and Monodiexodina cf. M. paralinearis which are suggestive of a late Sakmarian or early Artinskian (Per­
A Retrospective and Comparative Analysis of Clinical Outcomes of Kidney Transplant Recipients During First and Second COVID-19 Waves in North-West India

Introduction Kidney transplant recipients (KTRs) are prone to coronavirus disease 2019 (COVID-19) disease secondary to chronic immunosuppressive therapy. There have been differences in mortality and morbidity amongst the general population with different COVID-19 waves. This study is done to understand the effects of different COVID-19 waves amongst KTRs. Methods This was a retrospective single-centre trial from a high-volume transplant centre in North India. The immunosuppression protocol was changed according to national guidelines, and predictors of survival were evaluated. Results A total of 62 patients got infected during the first COVID-19 wave (March 2020 to February 2021) and 50 patients during the second COVID-19 wave (March 2021 to December 2021). Analysis showed a higher incidence of severe COVID-19 disease (79% vs. 50%) in the first wave, while the rest of the baseline parameters were similar in both waves. Mortality was similar in both groups. In both groups, severe COVID-19 disease, the requirement of hospitalisation, invasive oxygen therapy, and CT score findings were significant predictors of survival. There was no change in survival with respect to immunosuppression modification. Allograft dysfunction was more common in the second wave (7 vs. 1). Baseline creatinine was significantly associated with allograft dysfunction in follow-up. Conclusion Patients had severe COVID-19 disease during the first wave; however, poor availability of healthcare services during the second wave led to more patients with allograft dysfunction. Though immunosuppression change is necessary to prevent flare-ups of COVID-19 infection, it is not associated with survival benefits.
The Influence of Halal Label, Halal Brand Image, Halal Lifestyle, Halal Product Quality, and Halal Awareness on the Purchase Decision of Ms Glow Products

This study aims to examine and analyze the effect of halal labels, halal brand image, halal lifestyle, halal product quality, and halal awareness on purchasing decisions for MS Glow products. The population in this study are all consumers who buy MS Glow products. This research is included in explanatory research. The sampling technique in this study used a purposive sampling technique. The sample in this study were 192 respondents. The analytical method used in this study is multiple linear regression analysis using SPSS version 25. The results show that halal labels affect purchasing decisions, halal brand image influences purchasing decisions, halal lifestyle influences purchasing decisions, halal product quality influences purchasing decisions purchases, halal awareness affects purchasing decisions. The halal product quality variable has the most dominant influence in determining purchasing decisions for MS Glow products, therefore, companies are required to maintain and improve overall product quality in order to maintain and add consumers amidst very tight competition.
Analysis of definitive chemo-radiation outcomes in anal cancer: insights from a tertiary cancer center in the MENA Region

Background Outcomes of chemo-radiation (CRT) for anal cancer in Middle East and North Africa (MENA) are scarce. We aim to report treatment outcomes for anal cancer treated at tertiary cancer center, with a particular focus on patients managed with non-oncological surgery prior definitive CRT. Methods We conducted a retrospective review of patients diagnosed with locally advanced anal carcinoma, who underwent definitive CRT King Hussein Cancer Center, from January 2007 till January 2020. Patient demographics and disease characteristics were extracted, and a univariate chi-squared test was employed to assess the impact of chemotherapy type, HPV status, and pre-treatment non-oncological surgery on outcomes, including complete remission (CR), disease-free survival (DFS), and overall survival (OS). Kaplan–Meier tests were employed to analyze the obtained survival data. Results Among the 34 initially identified patients, 30 were eligible, 24 (80%) achieved CR. Notably, 20 out of 21 HPV positive patients achieved CR, versus 1 out 4 HPV-negative achieved CR, p=0.006The 5-years OS for HPV-positive patients was 89% compared with 25% for HPV-negative, p=0001. There was no statistical significant difference in patients outcomes as regard type of chemotherapy, radiation technique and non-oncologic resection prior to CRT. Conclusion Herein, we reported the first series of anal cancer from our region. CRT had yielded an oncologic outcome comparable with series in the literature. HPV-positive patients demonstrated better results. Moreover, we found non-oncologic resection prior to CRT did not seem to impact the outcomes. Further studies are warranted to overcome the limitations of our study.
Development of Tollmien-Schlichting disturbances in the presence of laminar separation bubbles on an unswept infinite wavy wing

The effect of long wavelength sinusoidal surface waviness on the development of TollmienSchlichting (TS) wave instabilities is investigated. The analysis is based on the compressible flow that forms over an unswept infinite wavy wing with surface variations of variable amplitude, wavelength and phase. Boundary layer profiles are extracted directly from the solutions of a Navier-Stokes solver, which allows a thorough parametric analysis to be undertaken. Many wavy surface configurations are examined that can be sufficient to establish localised pockets of separated flow. Linear stability analysis is undertaken using parabolised stability equations (PSE) and linearised NavierStokes (LNS) methods, and surface waviness is generally found to enhance unstable behaviour. Results of the two schemes are compared and criteria for PSE to establish accurate solutions in separated flows are determined, which are based on the number of TS waves per wavelength of the surface deformation. Relationships are formulated, relating the stability variations and the surface parameters, which are consistent with previous observations regarding the growth of TS waves on a flat plate. Additionally, some long wavelength surface deformations are found to stabilise TS disturbances.
Soil Carbon, Nutrients, and Phosphorus Fractions: Responses to Weed Control and Harvest Residual Retention in two 10-Year-Old Douglas-fir (Pseudotsuga menziesii) Stands of the Pacific Northwest

Intensive forest management techniques such as whole-tree harvesting and use of herbicides to control weeds can have an effect on nutrient cycling and nutrient pool sizes in the mineral soil. This study was conducted to measure differences in soil carbon (C), nutrient pools, or phosphorus (P) fractions associated with harvest-intensity (bole-only vs. whole-tree harvest) and weed-control treatments (initial weed control vs. five years of annual weed control) after ten years. Soil C, nitrogen (N), and P, and exchangeable calcium (Ca), potassium (K), magnesium (Mg), and Hedley P fractions were measured prior to treatment establishment and after ten years in two Douglas-fir (Pseudotsuga menziesii) plantations in the Pacific Northwest. We observed increases in most nutrient concentrations with initial weed control compared with annual weed control at Matlock, with opposite trends at Molalla. Exchangeable Ca and Mg content showed responses to weed control treatments. Harvesting treatments had no significant effects on soil C and nutrient pools at either site. Total P and many of the Hedley P fractions decreased over time, but these effects were ameliorated with the less-intensive initial-weed-control-only treatment at Matlock and the more-intensive annual-weed-control at Molalla. Ten-year responses suggest that harvesting intensity has not impacted potential for maintaining soil C and nutrient pools, with the exception of P, for long-term productivity. Knowledge of the on-site vegetative communities and their role in nutrient cycling is required to anticipate what effect weed control might have on nutrient pools through ensuing stand development.
The Role of the Brain-Derived Neurotrophic Factor in Chronic Pain: Links to Central Sensitization and Neuroinflammation

Chronic pain is sustained, in part, through the intricate process of central sensitization (CS), marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain pathways. Accumulating evidence suggests that CS is also driven by neuroinflammation in the peripheral and central nervous system. In any chronic disease, the search for perpetuating factors is crucial in identifying therapeutic targets and developing primary preventive strategies. The brain-derived neurotrophic factor (BDNF) emerges as a critical regulator of synaptic plasticity, serving as both a neurotransmitter and neuromodulator. Mounting evidence supports BDNF’s pro-nociceptive role, spanning from its pain-sensitizing capacity across multiple levels of nociceptive pathways to its intricate involvement in CS and neuroinflammation. Moreover, consistently elevated BDNF levels are observed in various chronic pain disorders. To comprehensively understand the profound impact of BDNF in chronic pain, we delve into its key characteristics, focusing on its role in underlying molecular mechanisms contributing to chronic pain. Additionally, we also explore the potential utility of BDNF as an objective biomarker for chronic pain. This discussion encompasses emerging therapeutic approaches aimed at modulating BDNF expression, offering insights into addressing the intricate complexities of chronic pain.
Childhood Hodgkin Lymphoma in Sub-Saharan Africa: A Systematic Review on the Effectiveness of the Use of Chemotherapy Alone

Introduction. Childhood Hodgkin lymphoma (HL) is often curable, but in Sub-Saharan Africa (SSA), access to standard treatments like combined chemotherapy and radiotherapy is limited. This study aimed at evaluating the effectiveness of using chemotherapy alone for children with HL in SSA. Methods. We searched Medline, Embase, Cinahl Plus and Cochrane Central databases for records of studies that evaluated childhood HL survival outcomes from January 2000 to December 2022. Results. Six observational studies were identified for inclusion, and 3 were included in the meta-analysis. Most HL cases included in the analysis presented with lymphadenopathy and the nodular sclerosing subtype, with a high percentage (80%) in advanced stages. The GRADE certainty of the evidence for the assessed outcomes was rated as very low. Overall survival with chemotherapy was 67.8% (95% CI: 42.1%-88.8%). Conclusion. Chemotherapy is a potential treatment choice for childhood HL in SSA. However, it is crucial to approach this option cautiously due to the limited certainty of the supporting evidence. To improve outcomes for affected children in SSA, more robust studies are needed, along with a focus on early detection and supportive care.
LIFE LESSON IN SCHOOL: EXPLORING TOLERANCE AMONG STUDENTS OF SMP N 1 BONTANG

The problem of tolerance in schools arises due to a lack of understanding of diversity, social, communication difficulties, and injustice in treatment so that the role of education is needed in shaping students who have an attitude of tolerance. The purpose of this study is to explore the level of understanding and practice of tolerance among students. This research is a quantitative study, with data acquisition through the survey method. The data collected will be analyzed descriptively to identify the level of understanding of students' tolerance attitudes in everyday life in the school environment. The results of this study indicate that although students at SMP N 1 Bontang are divided into several classes, and have religious differences, the students have a good level of understanding and practice of tolerance as evidenced by the results of the analysis assessment. This illustrates that the educational efforts and school environment at SMP N 1 Bontang was successful in promoting tolerance among students who have diverse backgrounds.
Assessment of Groundwater Quality in Some Rural Areas of The Federal Capital Territory, Abuja, Nigeria.

This research work was conducted to assess the quality of groundwater samples obtained from Durumi, Pigbakasa, Apo village, Kagini and Damangaza rural areas in federal capital territory, Abuja. The physicochemical properties and the concentration of some heavy metals in the water were determined using standard methods. The results obtained showed that the pH, electrical conductivity, alkalinity, hardness, total dissolved solids ranged between; 5.30 – 6.85, 39.8-276.8 , 5-80mg/l, 48-624mg/l, and 4-9100mg/l respectively. Pb, Cr and Cd ranged between 0.01-0.31mg/l, 0.08-0.49mg/l and 0.07-0.25mg/l. Bacteriological analysis indicated contamination of water. The results were compared to WHO/EPA/NSDQW standards which revealed that some of the water was mildly acidic, has low electrical conductivity and high concentration of Pb, Cr, and Cd. The groundwater from these areas is therefore contaminated with respect to some of the parameters determined. Dids Link : http://dids.info/didslink/05.2015-46281656/
Reliability and Mental Health Correlates of a Single-Item Measure of Self-Rated Mental Health (SRMH) in the Chinese Context

The use of single-item measures of self-rated mental health (SRMH) has been increasingly valued in epidemiologic research. However, little is known about the reliability and mental health correlates of SRMH in Chinese populations. This study examined the reliability and mental health correlates of SRMH in three Chinese samples. We analyzed data collected from two convenience samples of Chinese adults from Hong Kong and/or Taiwan (Sample 1: N = 205; Sample 2: N = 377), and a random sample of Taiwan psychiatric inpatients (Sample 3: N = 100). Our results showed that the single-item measure of SRMH had moderate to good test–retest reliability (intraclass correlation [ICC] = 0.75) in Sample 1 and acceptable reliability between the self-report and interviewer-administered versions (ICC = 0.58) in Sample 3. It had a high positive correlation with self-esteem and a moderately high negative correlation with depression. It also had a consistently negative correlation with borderline personality disorder symptoms and post-traumatic stress disorder symptoms. The SRMH score was also associated with psychiatric service usage. These findings contribute to the body of knowledge regarding the use of a single-item measure of SRMH to assess overall self-perceived mental health in Chinese communities.
Photophysical, thermal, and DFT studies on a tetraaryl-azadipyrromethene ligand and its zinc(II) complex

An azadipyrromethene ligand (H1) and homoleptic zinc(II) (H1-Zn) complex were synthesized. The resulting structures were elucidated by NMR, FTIR, and HRMS techniques. The photophysical properties and effects of complexing the zinc(II) atom to azadipyrromethene ligands in solution were studied by means of UV-Vis absorption and fluorescence spectroscopy. Experimental findings were elucidated using density functional theory computations and interfragment charge transfer (IFCT) and electron-hole analyses. The fluorescence features were found to be negligible. The ligand molecule decayed at a rate of 3% while the complex decayed at 2% upon photoirradiation based on photostability experiments. The singlet oxygen quantum yields of the ligand and complex were calculated as 0.127 and 0.233, respectively, signifying low photodynamic activity. The charge transfer transitions were determined between reciprocal ligands responsible for the red shift of the main absorption band by IFCT and electron-hole analysis. Compounds in an inert N2 atmosphere demonstrated high thermal stability. Although the thermogravimetric analysis (TGA) and derivative thermogravimetry curves of the complexes were similar, zinc(II) coordination and homoleptic complex formation reduced the degradation temperatures. These findings suggest that azadipyrromethene and the Zn(II) class of chromophores have beneficial features for use in the development of novel photo- and thermostable materials that combine charge transfer with low energy in the visible and near infrared regions.