EFFECTS OF CURCUMIN ON CARDIOVASCULAR RISK FACTORS IN OBESE AND OVERWEIGHT ADOLESCENT GIRLS: A RANDOMIZED CLINICAL TRIAL

Introduction: The risk of developing cardiovascular risk and obesity for obese teens is higher in adult life. Dietary intake as an active ingredient of turmeric extract of antioxidants particularly curcumin may have noticeable implications for obesity and its essential complications, including cardiovascular risk factors. The goal of this research was therefore, to determine cardiovascular risk factors in overweight and obese adolescents with the effects of curcumin supplementation. Methods: Fifty girls [aged 18 years] got placebo or intervention randomly. The teenagers were required to eat a standardised 95% turmeric extract or a placebo-containing one 500 mg pill daily, and to retain weight or a moderate weight loss diet for 10 weeks. The baseline and the conclusion of the intervention is measured with anthropometric and biochemical indexes. Results: The body's mass index [P=0.019], waist circumference [P=0.007], hip circumference [P=0.028], high density ratios of lipoprotein [P=0.046], and triglyceride/high density ratio of lipoprotein [P = 0.022] have positive results on curcumin supplementation. In univariate covariance study, however after 10 weeks of supplementation there have been no major variations between the intervention and placebo groups [P>0.05]. Conclusion: Prescription of curcumin supplements together with the implementation of a light weight loss diet may beneficially influence many overweight and obese women's cardiovascular risk factors. Larger clinical trials are required to validate the findings of the current research, with higher curcumin doses and longer duration. Corresponding author: Dr. Syeda Faiqa Batool Bukhari, MBBS, Rawalpindi Medical University, Rawalpindi. Please cite this article in press Syeda Faiqa Batool Bukhari et al, Effects Of Curcumin On Cardiovascular Risk Factors In Obese And Overweight Adolescent Girls: A Randomized Clinical Trial. , Indo Am. J. P. Sci, 2020; 07[12]. QR code IAJPS 2020, 07 [12], 2158-2163 Syeda Faiqa Batool Bukhari et al ISSN 2349-7750 w w w . i a j p s . c o m Page 2159 INTRODUCTION: The epidemic of overweight teenage patients is becoming a grave one in the world today. Overweight teens in adult adults, for example, have raised the incidence of obesity-related comorbidities as ischemic heart disease [1]. It appears that children's obesity [under 18] may be a significant indicator for adult comorbidities, such as hypertension and dyslipidemia. Thus, seeking a realistic alternative is highly important [2]. This is around 5% -13.5% and 3.2% -11.7%, respectively, among Iranian teenagers. It has been reported to be identified as the probable cause of childhood obesity by different lifestyle factors, including length of night sleep, physical exercise and the time spent watching television [3]. One research has shown that certain types of foods, such as spices, may play an important role in reducing obesity and its related complications [4]. In this sense, interest in turmeric extract has been increasingly focused, provided that its active ingredient is curcumin. Several studies have documented the possible impact of curcumin on obesity, inflammation, diabetes and cardiovascular disease and related risk factors [5]. However, the findings of the available research assessing the impact of curcumin on lipid profiles have been contradictory. One meta-analysis found that there was no beneficial effect of curcumin supplementation on lipid fractions [6]. Drawing upon our literature analysis we found no research evaluating any possible cardiovascular risk factors of curcumin supplementation in adolescents. Therefore it is important to choose this target group to assess the potential effects of curcumin.