Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Birmingham 11{beta}-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle

OBJECTIVE —Glucocorticoid excess is characterized by in- creased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11 ! -hydroxysteroid dehydrogenase type 1 (11 ! -HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to ac- tive cortisol (corticosterone in rodents). We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11 ! -HSD1 inhibitors improve insulin sensitivity. RESEARCH DESIGN AND METHODS —Rodent and human cell cultures, whole-tissue explants, and animal models were used to determine the impact of glucocorticoids and selective 11 ! -HSD1 inhibition upon insulin signaling and action. RESULTS —Dexamethasone decreased insulin-stimulated glu- cose uptake, decreased IRS1 mRNA and protein expression, and increased inactivating pSer 307 insulin receptor substrate (IRS)-1. 11 ! -HSD1 activity and expression were observed in human and rodent myotubes and muscle explants. Activity was predomi-nantly oxo-reductase, generating active glucocorticoid. A1 (se- lective 11 ! -HSD1 inhibitor) abolished enzyme activity and blocked the increase in pSer 307 IRS1 and reduction in total IRS1 protein after treatment with 11DHC but not corticosterone. In C57Bl6/J mice, the selective 11 ! -HSD1 inhibitor, A2, decreased fasting blood glucose levels and improved insulin sensitivity. In KK
Valid for two-period relaxations of big-bucket lot-sizing problems : zero setup

In this paper, we investigate two-period subproblems for big-bucket lot-sizing problems, which have shown a great potential for obtaining strong bounds. In particular, we investigate the special case of zero setup times and identify two important mixed integer sets representing relaxations of these subproblems. We analyze the polyhedral structure of these sets, deriving several families of valid inequalities and pre-senting their facet-deﬁning conditions. We then extend these inequalities in a novel fashion to the origi- nal space of two-period subproblems, and also propose a new family of valid inequalities in the original space. In order to investigate the true strength of the proposed inequalities, we propose and implement exact separation algorithms, which are computationally tested over a broad range of test problems. In addition, we develop a heuristic framework for separation, in order to extend computational tests to larger instances. These computational experiments indicate the proposed inequalities can be indeed very effective im proving lower bounds substantially.
INTENSIVE BLOOD PRESSURE LOWERING WITH AZILSARTAN IN INDIAN HYPERTENSIVE PATIENTS IN REAL-WORLD CLINICAL SETTINGS: INTENSE STUDY

Background: Hypertension (HTN) is ranked as third most important risk factor for attributable burden of cardiovascular disease. Azilsartan, because of highest responder rate, appears to be the most suited antihypertensive agent to achieve the target blood pressure (BP). As there is limited Indian clinical trial data and real-world studies on safety and effectiveness of azilsartan, this study was designed to investigate the ‘real-world’ effectiveness and safety of azilsartan in Indian hypertensive patients associated with Methods: This was a prospective, non-interventional, real-world study of Indian adult patients of diagnosed with essential HTN and prescribed with tablet azilsartan. Demographic data, details of treatment with azilsartan, changes in BP and occurrence of adverse events (AE) were noted during the follow-up visits (6 and 12 weeks). Results: Among 240 enrolled patients, mean reduction systolic BP from baseline with azilsartan was 16.2+11.1 mm Hg and 27.16+10.6 mm Hg (p<0.001) at Week 6 and Week 12 respectively. The proportion of patients achieving target systolic BP of ≤140 mm Hg was 56.70% at Week 12. The proportion of patients achieving aggressive target BP of <130/80 mm Hg was 40.42% at Week 12. In patients uncontrolled on telmisartan and shifted to azilsartan, the proportion of patients with target systolic BP of ≤140 mm Hg at Week 12 was 75%. Conclusion: The results of present real-world study suggest that azilsartan is effective and safe in the treatment of newly diagnosed treatment-naïve hypertensive patients as well as those uncontrolled on other antihypertensive agents including telmisartan with associated co-morbidities.
Efficacy of spring onion ( Allium fistulosum ) leaf extract for controlling major field insect pests of cowpea ( Vigna unguiculata L.) in the guinea savannah Agroecological zone of Ghana

The study was set up at University for Development Studies, Tamale, during the 2017 cropping season to assess the efficacy of spring onion extract for controlling major field insect pests of cowpea. The study was a single factor experiment, laid out in an RCBD with three replications. Treatments used were: T1= water, T2, T3, T4 and T5 were respectively made up of 5%, 10%, 15% and 20% of spring onion extract concentrations, T6= synthetic insecticide. Parameters measured were yield components, total yield, insect pest infestations. The highest grain yield was recorded by synthetic insecticide (3367 kg/ha), followed by 20% and 15% concentrations of spring onion extract, 3037 and 2940 kg/ha respectively. Treatment with water recorded the highest grain yield loss (76.15 %) followed by 5%, 10%, 15% and 20% concentrations of spring onion extract, recording yield losses of 67.83%, 21.80%, 12.68% and 1.10% respectively. This indicates that insect pests are economically important and their control is imperative for yield
Study on motivation and learner autonomy in learning English as Second Language (ESL)among Engineering students in Bhutan

The paper attempts to study technical students’ perception towards language learning. The study has selected students from an Engineering college where medium of instruction is in English. These participants have more than 12 years of education in English medium and they are studying one English course in the college. The study employed a questionnaire as a quantitative data collection tool. The questions used Likert- type scales adopted from Chan, Spratt, and Humphreys with slight modification. The study chose the affective variable- motivation as it’s a significant attribute in attaining learner autonomy. Learner autonomy is the ability of a student to take charge of their own learning. Language learning is not just a subject in their curriculum, it’s a skill for a language learner to communicate in target community with intelligible native-like fluency. The findings indicated that learners depend on teachers to take decision regarding teaching-learning and classroom management. This proves that autonomous language learning behavior is least found among the participants. However, the learners do have a sense of deciding their weakness, working harder, and to take initiative in learning language outside the class. This study attempts to provide an insight on pedagogical implication in using learner-centered approaches and instill motivation among learners so that they can build autonomy for independent and self-learning.
Non-small cell lung cancer is characterized by dramatic changes in phospholipid proﬁles

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death globally. To develop better diagnostics and more effective treatments, research in the past decades has focused on identification of molecular changes in the genome, tran-scriptome, proteome, and more recently also the metabolome. Phospholipids, which nevertheless play a central role in cell functioning, remain poorly explored. Here, using a mass spectrometry (MS)-based phospholipidomics approach, we profiled 179 phospholipid species in malignant and matched non-malignant lung tissue of 162 NSCLC patients (73 in a discovery cohort and 89 in a validation cohort). We identified 91 phospholipid species that were differentially expressed in cancer versus non-malignant tissues. Most prominent changes included a decrease in sphingomyelins (SMs) and an increase in specific phosphatidylinositols (PIs). Also a decrease in multiple phosphatidylserines (PSs) was observed, along with an increase in several phosphatidylethanolamine (PE) and phosphatidylcholine (PC) species, particularly those with 40 or 42 carbon atoms in both fatty acyl chains together. 2D-imaging MS of the most differentially expressed phospholipids confirmed their differential abundance in cancer cells. We identified lipid markers that can discriminate tumor versus normal tissue and different NSCLC subtypes with an AUC (area under the ROC curve) of 0.999 and 0.885, respectively. In conclusion, using both shotgun and words:
Protein Kinase PKR Mediates the Apoptosis Induction and Growth Restriction Phenotypes of C Protein-Deﬁcient Measles Virus (cid:1)

The measles virus (MV) accessory proteins V and C play important roles in MV replication and pathogenesis. Infection with recombinant MV lacking either V or C causes more cell death than infection with the parental vaccine-equivalent virus (MVvac), and C-deﬁcient virus grows poorly relative to the parental virus. Here, we show that a major effector of the C phenotype is the RNA-dependent protein kinase PKR. Using human HeLa cells stably deﬁcient in PKR as a result of RNA interference-mediated knockdown (PKR kd cells), we demonstrated that a reduction in PKR partially rescued the growth defect of C knockout (C ko ) virus but had no effect on the growth of either wild-type (WT) or V knockout (V ko ) virus. Increased growth of the C ko virus in PKR kd cells correlated with increased viral protein expression, while defective growth and decreased protein expression in PKR-sufﬁcient cells correlated with increased phosphorylation of PKR and the (cid:1) subunit of eukaryotic initiation factor 2. Furthermore, infection with WT, V ko , or especially C ko virus caused signiﬁcantly less apoptosis in PKR kd cells than in PKR-sufﬁcient cells. Although apoptosis induced by C ko virus infection in PKR-sufﬁcient cells was blocked by a caspase antagonist, the growth of C ko virus was not restored to the WT level by treatment with this pharmacologic inhibitor. Taken together, these results indicate that PKR plays an important antiviral role during MV infection but that the virus growth restriction by PKR is not dependent upon the induction of apoptosis. Furthermore, the results establish that a principal function of the MV C protein is to antagonize the proapoptotic and antiviral activities of PKR.
A validated gas chromatography-mass spectrometry method for the investigation of quetiapine-related deaths in Greece

Objective: Quetiapine is an atypical antipsychotic drug that is used to treat the symptoms of schizophrenia and other psychiatric disorders. During the last years, quetiapine has also been associated with cases of misuse and abuse, and there are strong indications that it possesses an addictive potential. A suitable method is necessary for the toxicological investigation of such cases. Materials and Methods: A simple gas chromatography-mass spectrometric method was developed, validated, and applied for the determination of quetiapine in biological fluids during the investigation of quetiapine-related cases. The sample preparation procedure includes solid-phase extraction and silylation using N-methyl-N-tert-butyldimethylsilyl-trifluoroacetamide with 1% tert-butyldimethylsilylchloride. Results: The limits of detection and quantification were 1.50 and 5.00 ng/mL, respectively. The calibration curves were linear up to 2000 ng/mL ( R 2 ≥ 0.991) and absolute recovery higher than 81%. Accuracy (intra- and inter-day) was found to be between −11.1 and 12.4%, whereas the precision was found to be <13.3%. The validated method was successfully applied to post-mortem blood samples during the toxicological investigation of 50 quetiapine-related sudden and violent deaths. Quetiapine was determined at toxic levels (>1800 ng/mL) in eight cases and at lower concentrations (5.21-1430 ng/mL) in the other 42 cases. It is remarkable to be mentioned that in all 50 cases one or more drugs were detected along with quetiapine. Conclusions: Quetiapine has been detected with increasing frequency in post-mortem cases in Greece during the last 3 years. This is in accordance with the growing concerns worldwide about the misuse or abuse of the drug and its contribution to the cause of death of quetiapine-related lethal cases. Physicians should be alert about the toxicity of quetiapine, its possible misuse or abuse, and its synergy with other drugs, medicinal or not, especially in patients under multiple drug therapy or drug addicts.
SARS-CoV-2 turned positive in a discharged patient with COVID-19 arouses concern regarding the present standard for discharge

: An outbreak of COVID-19 in Wuhan, China caused by SARS-CoV-2 has led to a serious epidemic in China and other countries, resulting in worldwide concern. With the active efforts from prevention and control, the quantity of discharged patients is escalating. How to manage these patients normatively is still challenging. We hereby reported an asymptomatic discharged patient with COVID-19 who was retested positive for SARS-CoV-2, which arouses concern regarding the present discharge standard of COVID-19.
McCartan, Rebecca and Elliott, Mark A. and Pagani, Stefania and Finnegan, Eimear and Kelly, Steve W. (2018) Testing the effects of explicit and implicit bidimensional attitudes on objectively measured speeding behaviour. British Journal of Social Psychology. ISSN 0144-

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Replica Placement Algorithm based on Peer Availability for P2P Storage Systems

—Peer-to-peer (P2P) technology is an emerging approach to overcoming the limitations of the traditional client server architecture. However, building a highly available P2P system is quite challenging, in particular a P2P storage system. The reason is due to the fundamental nature of P2P systems: peers can join and leave at any time without any notice. Replication is one of the strategies in overcoming the unpredictable behavior of peers. A good replication algorithm should use the minimum number of replicas to provide the desired availability of data. The popular approach in the previous studies is a random placement of replicas, but it ignores the wide difference in the availability of each peer. In this paper, we propose PAT (Peer Availability Table) in order to analyze and predict the state of nodes and develop a replica placement algorithm, which exploits the availability pattern of each individual peer. By comparing our algorithm with a random placement scheme, we show that our algorithm dramatically improves the data availability with moderate overhead in terms of memory consumption and processing time in both ideal and practical conditions. Additionally, we demonstrate the application of PAT as an analysis tool for various P2P systems.
NRAMP1 3 (cid:2) Untranslated Region Polymorphisms Are Not Associated with Natural Resistance to Brucella abortus in Cattle (cid:1)

The NRAMP1 gene encodes a divalent cation transporter, located in the phagolysosomal membrane of macrophages, that has been associated with resistance to intracellular pathogens. In cattle, natural resistance against brucellosis has been associated with polymorphisms at the 3 (cid:1) untranslated region (3 (cid:1) UTR) of the NRAMP1 gene, which are detectable by single-strand conformational analysis (SSCA). This study aimed to evaluate the association between NRAMP1 3 (cid:1) UTR polymorphisms and resistance against bovine brucellosis in experimental and natural infections. In experimentally infected pregnant cows, abortion occurred in 42.1% of cows with a resistant genotype (SSCA r ; n (cid:1) 19) and in 43.1% of those with a susceptible genotype (SSCA s ; n (cid:1) 23). Furthermore, no association between intensity of pathological changes and genotype was detected. In a farm with a very high prevalence of bovine brucellosis, the percentages of strains of the SSCA r genotype were 86 and 84% in serologically positive ( n (cid:1) 64) and negative ( n (cid:1) 36) cows, respectively. Therefore, no association was found between the NRAMP1 -resistant allele and the resistant phenotype in either experimental or naturally occurring brucellosis. To further support these results, bacterial intracellular survival was assessed in bovine monocyte-derived macrophages from cattle with either the resistant or susceptible genotype. In agree-ment with our previous results, no difference was observed in the rates of intracellular survival of B. abortus within macrophages from cattle with susceptible or resistant genotypes. Taken together, these results indicate that these polymorphisms at the NRAMP1 3 (cid:1) UTR do not affect resistance against B. abortus in cattle and that they are therefore not suitable markers of natural resistance against bovine brucellosis. Bovine brucellosis is Brucella and serum. Vaginal swabs for isolation and typing of Brucella were collected from nine cows with a recent history of parturition or abortion. Serum samples were analyzed for detection of anti- B. abortus antibodies by rose bengal plate agglutination test, standard tube agglutination test (STAT), and 2-mercaptoethanol (2-ME) test. Results were expressed as positive or negative for the RBPAT, and complete agglutination at a dilution of 1:25 or higher was considered positive by 2-ME test. Samples of vaginal swabs were plated on tryptose agar supplemented with antibiotics (Farrell’s medium— Brucella selec- tive supplement SR83; Oxoid, United Kingdom), and the isolated biovars were identiﬁed by routine methods as previously described (4). genotypes. ﬁndings genotype
An intelligent fuzzy theory for ocean structure system analysis

This paper deals with the problem of the global stabilization for a class of ocean structure systems. It is well known that, in general, the global asymptotic stability of the ocean structure subsystems does not imply the global asymptotic stability of the composite closed-loop system. The classical fuzzy inference methods cannot work to their full potential in such circumstances because given knowledge does not cover the entire problem domain. However, requirements of fuzzy systems may change over time and therefore, the use of a static rule base may affect the effectiveness of fuzzy rule interpolation due to the absence of the most concurrent (dynamic) rules. Designing a dynamic rule base yet needs additional information. In this paper, we demonstrate this proposed methodology is a flexible and general approach, with no theoretical restriction over the employment of any particular interpolation in performing interpolation nor in the computational mechanisms to implement fitness evaluation and rule promotion.
One-Stage Surgery for Two Conditions at the Same Vertebral Level: A Report of Two Cases and Literature Review

Background: Cases of isthmic spondylolisthesis, degenerative lumbar kyphosis, and schwannomas have been widely reported, but cases involving more than one such condition occurring concurrently at a single vertebral level have rarely been reported. Case Description: We present a case involving a female patient with isthmic spondylolisthesis combined with schwannoma that occurred at the same vertebral level, and a case involving a male patient with degenerative lumbar kyphosis combined with schwannoma that occurred at the same vertebral level. Preoperative examination, detailed physical examination, and general surgery-related consultation were performed before surgical treatment. The two patients underwent successful surgery, and a short-term follow-up showed that the symptoms were relieved. Conclusion: Schwannoma coexisting at the same vertebral level with lumbar spondylolisthesis or kyphosis may be over looked; the necessary auxiliary examinations and detailed specialist examinations may help identify such lesions. After a comprehensive assessment of patient status, one-stage surgery for lumbar spondylolisthesis/kyphosis with schwannoma is feasible.
Fluctuations in an Ideal Modified Bosonic Gas Trapped in an Arbitrary 3-dim Power-Law Potential

We analyze the number of particle fluctuations within the semiclassical approximation of an ideal bosonic gas with an anomalous single–particle dispersion relation suggested in several quantum– gravity approaches trapped in a generic 3–dimensional power–law potential as a criterium of thermodynamic stability for these systems. We show that the analysis of the fluctuations in the number of particles caused by a deformation in the dispersion relation, leads to an observable consequence associated to the thermodynamic stability for a specific choice of the trap parameters. Additionally, we deduce the shift in the critical temperature in the thermodynamic limit associated with this “modified bosonic gas” and show that this shift expressed in function of the number of particles, can be used as an amplifier for some quantum gravity manifestations for stable systems.
The Role of Social Networks in Delay of University Students Academics in Pakistan

The purpose of the study is to investigate the role of social network in academic delay of University students of Pakistan. The study design was the quantitative and applied descriptive. The population of the study was students of under graduate program of universities. Multistage cluster sampling techniques was used to select the respondents of the study. The size of sample was 375 participants of study. Primary data collection through questionnaire which was adopted in this study, from previous studies of Solomon and Rothblum Academic Procrastination Questionnaire (1984) and Social Networks Questionnaire developed by the authors. Data analyses for required data was performed in SPSS through tests were Mann Whitney and chi-square. The result of the study indicates that there is no difference between male and female respondents for delay behavioral change and unpleasant feeling caused by academic delay. The Online Social network components of the study have greatest correlation and impact on academic procrastination of the students in Universities.