Miracle-dz/UniFAR-FTUs huggingface dataset:
Vacuum Dependent Bell Local Hidden Variable Models and Generalized C.H.S.H. Inequalities

We extend a previous model of the author which generalizes Bell local hidden variable models to the case of entangled photon pairs assuming that the standard Bell correlation functions depend on a hidden vacuum index. We deduce a generalization of Bell theorem assuming that classical observables are not dichotomic and that photon pair emission and detection is not a stationary stochastic process. We derive a photon imperfect polarization correlation functions due to rotational invariance breaking induced by hidden vacuum spin currents. We implement formally this approach deducing a generalization of C.H. S.H. inequalities which asymptotically converges to the standard one and which might be competitive with standard quantum mechanics predictions. We suggest to test this inequalities conceiving new E.P.R. -Bell like tests with time dependent detector efficiency and photon flux. Finally, we suggest to apply these generalized inequalities to the correlation functions of entangled classical spinning waves realized recently with metamaterials.
PPA_A_262571 1361..1369

1Community-Based Psychiatric Care Research Center, Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran; 2Chronic Diseases (Home Care) Research Center, Autism Spectrum Disorders Research Center, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran; 3Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran; 4Noncommunicable Diseases Research Center (NCDRC), Fasa University of Medical Sciences, Fasa, Iran; 5Student Research Committee, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran; 6Noncommunicable Diseases Research center (NCDRC), Department of Medical Surgical Nursing, Fasa University of Medical Sciences, Fasa, Iran Introduction: Among the most common causes of death and disabilities worldwide, burn injuries can affect all aspects of the life quality of the burned patients. Despite the apparent impacts of resilience and self-efficacy on the quality of life, few studies have addressed the relationship among these variables in burned patients. Accordingly, the present study aimed to investigate the relationship among burned patients’ resilience and self-efficacy and their quality of life. Methods: The present study was a descriptive, cross-sectional research conducted on 305 burned patients hospitalized in the largest burns hospital in the south-east of Iran. In this regard, the subjects were selected based on total population sampling. Data were collected using a questionnaire consisting of four sections as follows: a demographic survey, ConnorDavidson Resilience Scale (CD-RISC), Lev Self-efficacy Scale, and Burn Specific Health Scale-Brief. The collected data were then analyzed using descriptive tests, Pearson correlation, and linear regression at a significance level of P<0.05 in SPSS 22. Results: The results show that there were significant positive correlations between the patients’ resilience and self-efficacy (P<0.001, r=0.31), resilience and quality of life (P<0.001, r=0.58), and self-efficacy and quality of life (P<0.001, r=0.63). Conclusion: It appears that burned patients’ self-confidence and ability in adjusting with their conditions after injury are correlated with their quality of life. Thus, it is recommended that healthcare policymakers adopt some strategies to improve resilience and self-efficacy in burned patients for enabling them to effectively cope with the stressful conditions that they face as a result of their injuries.
Diversity of Yeast Microbiota in Spoiled Iranian Doogh and Effects of Kluyveromyces marxianus on its Protein Profiles

Background and Objective: Microbial contamination can cause undesirable changes in food products. In addition to consumer’s health, these changes can challenge the product market. Doogh as one of the traditional dairy may be contaminated by a wide range of microbiota. Awareness of the contaminant types can be an accurate strategy to eliminate contaminations. Regarding importance of food safety as well as industry demand, the present study was an attempt to better understanding of the yeast microbiota diversity in spoiled Doogh. Also the effect of predominant yeast metabolites on proteins and peptides profiling of Doogh were investigated. Results demonstrated purposeful industrial strategies to secure quality parameters and boost the shelf life of Doogh. Material and Methods: Swollen packages of pasteurized Doogh samples were collected from a local dairy plant within one year. Identification was carried out using morphological, biochemical and molecular techniques. Then, protein and peptide profiles of the inoculated Doogh samples with high proteolytic activities of the isolated yeasts were compared with control using SDS-PAGE and MALDI-TOF-MS techniques. Results and Conclusion: Totally, 13 isolates belonged to two genera of Kluyveromyces and Candida were isolated and identified. Based on 18S rRNA gene sequencing, eight isolates were identified as Kluyveromyces marxianus ; four isolates were matched with Kluyveromyces lactis and one isolate was identified as Candida kefyr . Furthermore, o-phthaldialdehyde assay showed that Kluyveromyces marxianus contain the highest proteolytic activity, compared to other identified isolates. Results showed that the activity of Kluyveromyces marxianus linked the protein profiles to β-lactoglubolin and α-lactalbumin isoforms and several peptides with molecular weight less than 10 kDa. Small changes in organoleptic properties can directly affect the product marketing and jeopardizes survival of the industries. By increasing necessary measures on the critical points in the production lines, adoption of right strategies to decrease or eliminate contaminants and hence improve the quality of the products is possible. Conflict of interest: The authors declare no conflict of interest.
Proactive telephone counseling as an adjunct to minimal intervention for smoking cessation: a meta-analysis

Proactive telephone counseling is an effective adjunct to minimal intervention for smoking cessation, but its effect has not been quantitatively synthesized thoroughly. The present meta-analysis reviewed 22 studies published between January 1990 and December 2003 and found that there was a heterogeneous, signiﬁcant adjunct effect of proactive telephone counseling for smoking cessation. This meta-analytic review also found that the following study characteristics explained most of the variation in the adjunct effect: year of publication, follow-up time, mean age of participants, proportion of female participants, participants’ readiness to quit smoking and number of cigarettes smoked per day before intervention. In other words, based on the 22 studies, proactive telephone counseling is effective as an adjunct to other minimal interventions for younger, male, light-smoking participants. The results of this meta-analytic review imply that researchers and health care providers may need to focus on participants as much as on intervention process to obtain more effective interventions.
Differential parental BRCA1 expression in human embryos Differential expression of parental alleles of BRCA1 in human preimplantation embryos

15 Gene expression from both parental genomes is required for completion of embryogenesis. 16 Differential methylation of each parental genome has been observed in mouse and human 17 preimplantation embryos. It is possible that these differences in methylation affect the level 18 of gene transcripts from each parental genome in early developing embryos. The aim of this 19 study was to investigate if there is a parent specific pattern of BRCA1 expression in human 20 embryos and to examine if this affects embryo development when the embryo carries a 21 BRCA1 or BRCA2 pathogenic variant. 22 Differential parental expression of ACTB , SNRPN , H19 and BRCA1 was semi-quantitatively 23 analysed by mini-sequencing in 95 human preimplantation embryos obtained from 15 24 couples undergoing preimplantation genetic diagnosis (PGD). 25 BRCA1 was shown to be differentially expressed favouring the paternal transcript in early 26 developing embryos. Methylation specific PCR showed a variable methylation profile of 27 BRCA1 promoter region at different stages of embryonic development. Embryos carrying 28 paternally inherited BRCA1 or 2 pathogenic variants were shown to develop more slowly 29 compared to the embryos with maternally inherited BRCA1 or 2 pathogenic variants. 30 This study suggests that differential demethylation of the parental genomes can influence 31 the early development of preimplantation embryos.
An Empirical Evaluation of the Accuracy of NESMA Function Points Estimates

—Functional size measures of software—especially Function Points—are widely used, because they provide an objective quantiﬁcation of software size in the early stages of development, i.e., as soon as functional requirements have been analyzed and documented. Unfortunately, in some conditions, performing the standard Function Point Analysis process may be too long and expensive. Moreover, functional measures could be needed before functional requirements have been elicited completely and at the required detail level. To solve this problem, many methods have been invented and are being used to estimate functional size based on incomplete or not fully detailed requirements. Using these methods involves a trade-off between ease and timeliness on one side and accuracy on the other side. In fact, estimates are always affected by some error; knowing the magnitude of estimation errors that characterize the estimates provided by a given method is of great importance to people who use size estimates. This paper reports the results of an empirical study devoted to evaluate the accuracy of estimates provides by ‘NESMA estimated’ and ‘NESMA indicative’ methods, which are among the best known and most widely used Function point estimation methods. The results of the study show that the NESMA estimated method provides estimates that are accurate enough for practical usage.
University of Birmingham Triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention

Patients undergoing percutaneous coronary intervention (PCI) are treated with dual antiplatelet therapy to reduce the risk of subsequent myocardial infarction and stent thrombosis. Approximately 5-10% of patients undergoing PCI also have atrial fibrillation (AF). Patients with AF have an additional requirement for anticoagulation, as dual antiplatelet therapy alone is insufficient to adequately reduce the risk of stroke in patients with AF. However, it is now well-established that combining anticoagulants with dual antiplatelet therapy also causes a significant increase in the risk of bleeding. Hence, there is great interest in discovering the optimal blend of antiplatelet therapy and oral anticoagulation in this situation, aiming to reduce the risk of stent thrombosis, recurrent MI, and stroke, whilst also minimizing the risk of bleeding. Recent studies have experimented with combining oral anticoagulation with a single antiplatelet agent, rather than combining oral anticoagulation with dual antiplatelet therapy. These studies show that this reduces the risk of bleeding, but are underpowered to determine whether this still provides as much cardiovascular benefit. This review summarizes the currently available evidence on this topic and highlights the key questions that remain to be answered including ongoing clinical trials in the field.
A REVIEW A reconsideration of the evidence for Escherichia coli STa (heat stable) enterotoxin-driven ﬂuid secretion: a new view of STa action and a new paradigm for ﬂuid absorption

A review of the evidence for Escherichia coli STa causing ̄uid secretion in vivo leads to the conclusion that the concept of STa acting through enhanced chloride secretion in order to derange intestinal function is unproven. However, a consistent effect of STa in the small intestine is on Na/H exchange, leading to interruption of luminal acidi®cation. A model for the action of STa, involving inhibition of Na/H exchange, is proposed which explains the ability of STa to reduce absorption in vivo but its inability to cause secretion in vivo in contrast to its apparent secretory effect in vitro. The apparent ability to demonstrate secretion in vitro is shown to derive from methodologies which do not involve measurement of mass transport of water but instead, infer it from in vitro and in vivo proxy measurements. The in vitro demonstration of notional secretion after STa exposure can be reconciled with the proposed new model for ̄uid absorption in that cell swelling is argued to arise as a transient consequence of STa challenge followed by regulatory volume decrease. Evidence for this derangement model is presented in the form of observations derived from acute in vivo physiological studies and clinical studies on patients without the exchanger. This process of appraisal of the evidence for the mechanism of action of STa has led to a new model for ̄uid absorption. This is based on the formation of hypotonicity at the brush border luminal surface rather than hypertonicity within the lateral spaces as required by the present standing gradient model of ̄uid absorption. Evidence from the literature is presented for this new paradigm of water absorption, which may only be relevant for small intestine and other tissues that have Na/H exchangers in contact with HCO3 containing solutions but which may also be generalizable to all mammalian absorbing epithelial membranes. 1. Summary, 7 2. Introduction, 8 3. Existing model of net ̄uid transport, 8 4. A new model for net ̄uid absorption, 10 5. Evidence for the new model for net ̄uid absorption, 12 5.1 Evidence from altering ambient carbon dioxide levels, 13 5.2 The role of carbonic anhydrase in net ̄uid absorption, 14 5.3 Evidence from perfusion with antibiotics, 14 5.4 Evidence from chronic animal models of diarrhoeal disease and resection studies, 14 5.5 Evidence from oral rehydration solution studies, 15 5.6 Evidence from numerical calculations, 16 5.7 Evidence from gene product deletion studies, 17 6. Lack of evidence for the present model of Sta-driven intestinal secretion, 17 6.1 Changes in short circuit current in Ussing chamber studies, 17 6.2 Evidence from T 84 cell studies, 17 6.3 Proxy in vivo systems, 18 6.4 Short duration perfused in vivo loops, 18 6.5 Notional bicarbonate secretion in vivo and in vitro, 19 7. Reconciliation of the new model for ̄uid absorption with STa action, 21 7.1 Experimentally based evidence, 21 7.2 Clinical evidence from enzyme deletion, 22 8. Acknowledgements, 23 9. References, 23
A Correlational Study between the Big Five Personality Traits and Plagiarism

: An advent of electronic media has increased plagiarism. People around the world are relying on the vast number of data available on internet. This paves an easy road towards plagiarism. It has now entered in to the different areas of life and affects an intellectual growth of the people. The current study is a comprehensive study of plagiarism in relation to the five factor model of personality. Data was collected from the University of Karachi. Students from different departments of social sciences were added into the final sample. 231 students participated in this study. The results of this study were analyzed through correlation analysis technique. Results showed that plagiarism was positively related with agreeableness, conscientiousness, extraversion and openness to experience. No statistically significant relationship was found between plagiarism and neuroticism. The findings were further discussed in relation with the Pakistani context.
Application of Real-Time Hybrid Simulation Method in Experimental Identification of Gyromass Dampers

Structural control techniques have been extensively explored in the past decades, contributing to substantial safety improvements. Still, recent experience shows that the property damage resulting from even a moderate earthquake is significant. This dissertation studies the design and development of a new mechanical vibration absorber (i.e., gyromass damper or GMD) that uses gear assemblies to generate acceleration-proportional resisting forces. Similar to dynamic vibration absorbers such as tuned mass dampers, GMDs allow the introduction of control forces that are caused by inertial forces. However, unlike tuned mass dampers, they do not require a large additional physical mass. With the aim of incorporating GMDs in real structures, sample configurations are presented that are simple to build, and the effectiveness, robustness, and limitations of these devices for linear systems are investigated. This dissertation has two main foci regarding the application of GMDs for passive control of structures. The first is to improve the current state of the literature by characterizing and modelling the dynamic behaviour of GMDs. While the second is the application of real-time hybrid simulation method as a dynamic testing tool to experimentally examine the effects of GMDs on the performance of SDOF systems. The
WAS COMET C/1945 X1 (DU TOIT) A DWARF, SOHO-LIKE KREUTZ SUNGRAZER?

The goal of this investigation is to reinterpret and upgrade the astrometric and other data on comet C/1945 X1, the least prominent among the Kreutz system sungrazers discovered from the ground in the twentieth century. The central issue is to appraise the pros and cons of a possibility that this object is—despite its brightness reported at discovery—a dwarf Kreutz sungrazer. We confirm Marsden’s conclusion that C/1945 X1 has a common parent with C/1882 R1 and C/1965 S1, in line with the Sekanina & Chodas scenario of their origin in the framework of the Kreutz system’s evolution. We integrate the orbit of C/1882 R1 back to the early twelfth century and then forward to around 1945 to determine the nominal direction of the line of apsides and perform a Fourier analysis to get insight into effects of the indirect planetary perturbations. To better understand the nature of C/1945 X1, its orbital motion, fate, and role in the hierarchy of the Kreutz system, as well as to attempt detecting the comet’s possible terminal outburst shortly after perihelion and answer the question in the title of this investigation, we closely examined the relevant Boyden Observatory logbooks and identified both the photographs with the comet’s known images and nearly 20 additional patrol plates, taken both before and after perihelion, on which the comet or traces of its debris will be searched for, once the process of their digitization, currently conducted as part of the Harvard College Observatory’s DASCH Project, has been completed and the scanned copies made available to the scientific community.
Impact of Phenotype Deﬁnition on Genome-Wide Association Signals: Empirical Evaluation in Human Immunodeﬁciency Virus Type 1 Infection

Discussion on improving the power of genome-wide association studies to identify candidate variants and genes is generally centered on issues of maximizing sample size; less attention is given to the role of phenotype deﬁnition and ascertainment. The authors used genome-wide data from patients infected with human immunodeﬁciency virus type 1 (HIV-1) to assess whether differences in type of population (622 seroconverters vs. 636 seroprevalent subjects) or the number of measurements available for deﬁning the phenotype resulted in differences in the effect sizes of associations between single nucleotide polymorphisms and the phenotype, HIV-1 viral load at set point. The effect estimate for the top 100 single nucleotide polymorphisms was 0.092 (95% conﬁdence interval: 0.074, 0.110) log 10 viral load (log 10 copies of HIV-1 per mL of blood) greater in seroconverters than in seroprevalent subjects. The difference was even larger when the authors focused on chromosome 6 variants (0.153 log 10 viral load) or on variants that achieved genome-wide signiﬁcance (0.232 log 10 viral load). The estimates of the genetic effects tended to be slightly larger when more viral load measurements were available, particularly among seroconverters and for variants that achieved genome-wide signiﬁcance. Differences in phenotype deﬁnition and ascertainment may affect the estimated magnitude of genetic effects and should be considered in optimizing power for discovering new associations.
MeMAD Deliverable D 4 . 1 Report on Multimodal Machine Translation

Multimodal machine translation involves drawing information from more than one modality (text, audio, and visuals), and is an emerging subject within the machine translation community. In MeMAD, multimodal translation is of particular interest in facilitating cross-lingual multimodal content retrieval, and is one of the main focuses of WP4. Though multimodal machine translation efforts have been emerging since the early 1990s, there has not been research on a large scale until the last decade. Especially prominent are the multimodal tasks of spoken language translation and image caption translation, exploiting audio and visual modalities respectively. Both of these tasks are championed by evaluation campaigns, acting as competitions to stimulate research and to serve as a regulated platform investigating evaluation methodologies. So far, one multimodal machine translation system has been developed within WP4 of the MeMAD project for either task, and especially the image caption translation system had great success. In this deliverable, we present a survey of the state of the art in machine translation with an emphasis on multimodal tasks and systems. Later, we describe our own multimodal machine translation efforts carried out in WP4 within the first year of MeMAD. Finally, to conclude our report, we discuss our plans of tackling video subtitle and audio description translations as the next steps in WP4. 2 MeMAD – Methods for Managing Audiovisual Data Deliverable 4.1
ER a , ER b , and gpER: novel aspects of oestrogen receptor signalling in atherosclerosis

Cardiovascular disease represents the leading cause of mor-bidity and mortality in women. Epidemiological and experimental evidence indicates several atheroprotective effects of endogenous oestrogens, which interfere with atherosclerosis progression and inﬂammation. Nevertheless, oestrogen receptor function across different stages of atherosclerosis development remains poorly characterized. This viewpoint editorial discusses the current knowledge of oestrogen receptor function in physiology and within different stages of atherogenesis. Increasing our understanding of the molecular mechanisms determining oestrogen action in humans, with and without established atherosclerosis, may help to develop new strategies for the treatment of cardiovascular disease in women, and possibly also in men. receptor-associated co-regulatory proteins, such as NM23-H2, is altered, and ER b expression changes in advanced atherosclerosis. Local formation of biologically active oestrogens through aromatase and other pathways appears to be reduced (E 2 # ) under these conditions. Based on these changes of oestrogen receptor signalling in advanced atherosclerosis, it is currently not clear how endogenous oestrogens affect oestrogen-dependent proteins involved in inﬂammation and structure of the athero- sclerotic plaque, such as inﬂammatory nitric oxide synthase (iNOS) and matrix metalloproteinases (MMP). This illustrates the complexity of action of oestrogens and how equine oestrogen mixtures containing hormonal substances of unidentiﬁed activity affect oestrogen receptor function and regulation of oestrogen- sensitive genes in the presence of atherosclerosis. gpER, G protein-coupled estrogen receptor.