Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-Management in Patients with Rheumatoid Arthritis

Despite the effective pharmacological management of the disease over the last two decades, many individuals with RA continue to have psychological distress, and this is associated with poor outcomes. Addressing psychological issues hand in hand with pharmacological treatment will help to maximize outcomes for people with RA. Self-management (SM) is of utmost importance for people with rheumatoid arthritis to minimize their complaints, reduce clinic visits, and reduce disability. Considering the continuous update on the guidelines for disease management, non-pharmacological management remains a poorly addressed need of importance. In this chapter, we will introduce the current and progress of self-management in patients with rheumatoid arthritis.
Molecular phylogeny of the pond treaders (Insecta: Hemiptera: Heteroptera: Mesoveliidae), discussion of the fossil record and a checklist of species assigned to the family

The phylogenetic relationships among selected species and genera of Mesoveliidae (Insecta: Hemiptera: Heteroptera: Gerromorpha) were investigated in a parsimony analysis of 2858 bp of DNA sequence data from the genes encoding COI + II, 16S rRNA and 28S rRNA. The resulting phylogeny showed that Mesoveloidea williamsi Hungerford, 1929, from the subfamily Madeoveliinae, was sister group to Mniovelia Andersen & J.T. Polhemus, 1980, from the Mesoveliinae, thus making the latter subfamily paraphyletic. The genus Mesovelia Mulsant & Rey, 1852 also showed to be paraphyletic, since an undescribed Laotian relative of M. indica Horvath, 1915 and M. ujhelyii Lundblad, 1933 resulted as sister group to Phrynovelia Horvath, 1915; and M. amoena Uhler, 1894 was sister species to Speovelia maritima Esaki, 1929. Whereas these relationships were poorly or moderately supported, the remaining species of Mesovelia formed two distinct and well-supported clades, one comprising M. horvathi Lundblad, 1933, M. hackeri Harris & Drake, 1941, and two undescribed species from Nigeria and New Caledonia, and another comprising M. vittigera Horvath, 1895, M. stysi J.T. Polhemus & D.A. Polhemus, 2000, M. ebbenielseni Andersen & Weir, 2004, M. furcata Mulsant & Rey, 1952, and M. mulsanti White, 1879. A large genetic difference was found between populations of M. vittigera from Europe and Africa on one side and populations from Australia and New Caledonia on the other. DNA sequence data from a Japanese “M. vittigera” obtained from GenBank placed the specimen as strongly supported sister group to a Danish specimen of M. furcata. Comparisons of the 28S rRNA sequence data between the two specimens revealed a single C/T transition, while comparison with a Chinese female of M. furcata revealed one A/G and one C/T transition, thus suggesting mislabelling of the Japanese specimen, or an unrecognized presence of M. furcata in Japan. Considerable genetic differentiation was found between specimens of M. horvathi from Australia, New Caledonia, New Guinea, and Laos, and between sympatric specimens of M. mulsanti from Honduras, thus supporting earlier ideas of species-complexes in these two clades. Samples of Austrovelia caledonica Malipatil & Monteith, 1983 from New Caledonia and Mniovelia kuscheli Andersen & J.T. Polhemus, 1980 from New Zealand’s North Island also revealed considerable intraspecific divergences indicating genetic isolation among geographically separated populations on these ancient islands.
Efficacy and Safety of Evocalcet Evaluated by Dialysate Calcium Concentration in Patients with Secondary Hyperparathyroidism Undergoing Hemodialysis

Purpose Evocalcet is a novel oral calcimimetic drug that has demonstrated similar efficacy to cinacalcet in regulating serum parathyroid hormone (PTH), calcium, and phosphate levels, with fewer upper gastrointestinal tract-related adverse drug reactions (ADRs) in patients with secondary hyperparathyroidism undergoing hemodialysis in Japan. We investigated the efficacy and safety of once-daily oral evocalcet under different dialysate calcium concentrations. Patients and Methods A post hoc analysis by dialysate calcium concentration (2.5, 2.75, and 3.0 mEq/L) was performed using data from a previous Phase 3 study that included cinacalcet as an active control. Efficacy endpoints were the proportion of patients who achieved the target intact PTH levels of ≥60 and ≤240 pg/mL between Week 28 and Week 30; time-course changes in serum intact PTH; calcium and phosphorus levels, bone turnover markers, and fibroblast growth factor 23 (FGF23) over the 30-week study period. Safety endpoints were overall ADRs and hypocalcemia- and upper gastrointestinal tract-related ADRs. Results A total of 634 patients were included in the analysis. Levels of intact PTH, calcium, phosphate, bone turnover markers, and FGF23 showed improvement in all sub-groups, irrespective of dialysate calcium concentration. The incidence of upper gastrointestinal tract-related ADRs was significantly lower in the evocalcet group than the cinacalcet group with dialysate calcium concentrations of 2.75 and 3.0 mEq/L (p<0.05 for both concentrations). Conclusion Evocalcet was effective and safe in regulating the levels of serum intact PTH, calcium, and phosphate in patients with secondary hyperparathyroidism undergoing hemodialysis, irrespective of dialysate calcium concentration.
UTAUT Model Implementation On User Behavior In Use Of Information Technology

Purpose analyze and retest the technology use and acceptance model proposed by Venkatesh et al. (2003) where there are four main variables that affect user intention and user behavior in using information technology. Methodology this study uses a quantitative method, and data obtained using questionnaires. Sampling uses survey techniques with a total sample of 50 employees of the Tourism and Culture Office of Malang Regency. The analysis technique in processing data uses the SPSS program. Research findings this study shows that in the technology acceptance model, user intention and user behavior can be influenced by four variables such as performance, effort, social influence, and supporting conditions. DOI: https://doi.org/10.26905/jtmi.v6i1. 4156
A cytotaxonomic study in twelve Brazilian taxa of stylosanthes Sw., Leguminosae

The karyotypes of twelve diploid taxa (2n=20) of the Stylosanthes, Leguminosae, were analysed. The genus has a very conservative karyological pattern. The comparison among taxa belonging to the controversial S. guiananesis species complex, showed clear differences in size of their chromosome complements and morphology, which suggest that this group is under a process of chromosome evolution by the occurrence of rearrangements and changes in DNA content. The analysis of four species unrelated to this complex showed clear differences among their karyotypes.
Clozapine Protective Effect on Suicide Behavior in Schizophrenics

Introduction: The World Health Organization estimates that, by 2020, about 1.5 million people will die of suicide, representing approximately 2.4% of all deaths worldwide. Suicide is highly associated with psychiatric disorders, including schizophrenia. Objective: To investigate the protective effect of clozapine in a schizophrenic patient with suicidal behavior. Method: Non-exhaustive narrative review highlighting the main works published since 2011, in the electronic database MEDLINE, by the use of the keywords, in English, “clozapine”, “schizophrenia”, “risk”, “suicide”. Results: Studies have shown that clozapine is a psychopharmacological alternative of a protective effect on the risk of suicide in schizophrenics. Clozapine is the only atypical antipsychotic approved by the FDA with a prophylactic indication in these psychiatric settings.
The ecological function of extrafloral nectaries : herbivore deterrence by visiting ants and reproductive output in Caryocar brasiliense (Caryocaraceae)

1. Shrubs of Caryocar brasiliense are intensively visited by many ant species in the cerrado vegetation of south-east Brazil. Ants collect nectar from the extrafloral nectaries (EFNs) located on the buds at the apex of the plant. 2. The proportion of C. brasiliense shrubs occupied by ants greatly surpassed that of neighbouring plants without EFNs and this resulted in many more termites being attacked and removed on this plant than on plants lacking EFNs. Ant attacks on Caryocar were more frequent near the EFNs. 3. Ant-exclusion experiments with Caryocar shrubs revealed that ants significantly reduce the infestation levels by the butterfly Eunica bechina, the sucking bud Edessa rufomarginata, the bud-destroying fly Prodiplosis floricola and by a stem-galling wasp. Ants had no effect on the infestation by a leaf-galling wasp. 4. Control (ants present) and treatment (ants excluded) plants produced equal numbers of buds but flower and initial fruit production was significantly greater for ant-visited plants. Higher abortion rates of initial fruits by control plants resulted in similar final fruit and seed sets for plants in either experimental category. 5. The extremely low fertility of cerrado soils is suggested as a possible factor constraining the ability of Caryocar shrubs to provide the resources necessary for growth and development of their heavy fleshy fruits. Higher production of initial fruits by ant-visited shrubs would be neutralized by competition among developing fruits and subsequent abortion. 6. Possible ant-derived benefits to C. brasiliense include: protection of vegetative tissues during plant growth, larger floral display and increased attractiveness to bat pollinators, increased male contribution to fitness through pollen donation and selective abortion of genetically inferior progeny as the maternal investment is adjusted to match available resources.
Effect of prolonged dark incubation on pigments and photosynthesis of the cave-dwelling cyanobacterium Phormidium autumnale (Oscillatoriales, Cyanobacteria)

F. Montechiaro and M. Giordano. 2006. Effect of prolonged dark incubation on pigments and photosynthesis of the cave-dwelling cyanobacterium Phormidium autumnale (Oscillatoriales, Cyanobacteria). Phycologia 45: 704–710. DOI: 10.2216/06-15.1 The effect of prolonged darkness on the photosynthetic apparatus of the cyanobacterium Phormidium autumnale was investigated under nonheterotrophic conditions. The purpose of this study was to better understand the processes that allow this organism to rapidly resume growth after prolonged exposure to darkness, as it is often the case in show caves, where periods of darkness are applied to reduce algal proliferation. Phormidium autumnale was subjected to 4 weeks in the dark; this treatment elicited a large decrease in the cells' photosynthetic capacity (Pmax), while the photosynthetic affinity for photons (α) was affected to a smaller degree. Chlorophyll a and carotenoid contents were approximately constant over the 4 weeks of dark incubation, whereas the amount of phycobilins (phycocyanin, allophycocyanin and phycoerythrin) per cell decreased by 50% between the first and the last week of incubation. The relative abundance of the three phycobilins did not vary throughout the treatment, suggesting that the decrease in the number of phycobilisomes was not paralleled by changes in their relative composition. Upon re-exposure to light, cells promptly resumed photosynthesis and were able to cope with high irradiance up to 1600 μmol photons m−2 s−1. The resilience of the photosynthetic apparatus of P. autumnale in the dark may be one of the features that determine the prevalence of this organism in the cave flora at the expenses of more dark-sensitive photolithotrophs (i.e. organisms whose photosynthetic apparatus is substantially reduced or disassembled in the dark).
Circular RNA ﻿CircPRMT5 Accelerates Proliferation and Invasion of Papillary Thyroid Cancer Through Regulation of miR-30c/E2F3 Axis

Background The role of circular RNA (circRNA) in papillary thyroid cancer (PTC) is largely unknown. This study aims to determine the function and mechanism of circPRMT5 in the regulation of PTC development. Methods PTC tissues and cell lines were used to determine circPRMT5 expression via quantitative real-time polymerase chain reaction. Small interfering RNA (siRNA) was utilized to knock down circPRMT5. Proliferation was analyzed through CCK8 and colony formation assays. Transwell assay was performed to determine cell migration and invasion. Luciferase assay and RIP assay were carried out to analyze the interaction between circPRMT5 and miR-30c. Results ﻿CircPRMT5 expression was upregulated in PTC tissues and cell lines. And circPRMT5 level was positively linked with advanced stage and lymph node metastasis. ﻿CircPRMT5 knockdown inhibited proliferation, migration and invasion while inducing apoptosis. ﻿CircPRMT5 worked as a competing endogenous RNA for miR-30c. By inhibiting miR-30c, circPRMT5 promoted the expression of E2F3. Conclusion Our findings demonstrate that circPRMT5 acts as an oncogenic circRNA to promote PTC progression via regulating miR-30c/E2F3 axis.
Hemorrhoidectomy in Patients with Grade III and IV Disease: Harmonic Scalpel compared with Conventional technique.

Objectives: To compare conventional hemorrhoidectomy with harmonic scalped hemorhoidectomy in terms of pain outcome as a patient perceives, time taken for operation and length of stay in hospital. Study Design: Randomized controlled trial. Setting: Services hospital Lahore. Period: From August 2015 to February, 2016. Material & Methods: Patients were divided into two equal groups: Group A: conventional hemorrhoidectomy and Group B: Harmonic Scalpel. The study was performed by a single surgical operating team. Patient’s selection criteria were male and female between 20 to 80 ages with III and IV degree hemorrhoids. The outcomes were operative time, post-operative pain and duration of stay in the hospital. Results: One hundred patients with mean age 40.86+10.26 were included and randomly assigned. This came out significant difference in operative time 28.4+11.004, postoperative pain 3.73+1.96, and length of hospital stay 2.43+1.795. There were equal distribution in age and gender in both groups. Conclusions: It is concluded that harmonic scalpel technique in hemorrhoidectomy is better than conventional closed hemorrhoidectomy in 3rd and 4th degree hemorrhoids.
Factors Contributing to the Difficulties in Teaching and Learning of Computer Programming: A Literature Review

This paper reviews the literature relating to the factors that contribute to the difficulties in learning of computer programming. Programming has been a difficult subject to learn and master even at the early stage of education. It has been a global problem and continues to worsen at the local level. Although, there are many education tools available to complement the teaching and learning of computer programming. The problem persists until present day. Even at the initial stage of computer introduction courses, there were high failure rates and high drop out. One of the rationalism behind this scenario is from the students’ lack of problem solving abilities. However, the problem does not only lie within the students’ level of efficacy. It involves the effective use of teaching and learning material as well. Therefore, the focus of this review is on the factors concerning the students learning method and the effectiveness of the teaching material. Based on plethora of literature review, it is vital that these two aspects need to be consider simultaneously to overcome the difficulties of learning computer programming. A much more comprehensive, effective and universal teaching and learning tools need to be design to address the severity of this problem.
Characterization of a species‐specific satellite DNA of Drosophila buzzatii

The pBuM189 satellite DNA family was found to be species specific for Drosophila buzzatii. It consists of slightly AT-rich tandemly arranged repeats with a high copy number in the genome and shows a very high level of intraspecific sequence similarity. pBuM189 repeats cannot be detected in the genomes of closely related species such as Drosophila serido, Drosophila borborema and Drosophila koepferae. The data support the marginal systematic position of D. buzzatii within the buzzatii cluster of the Drosophila repleta group.
Inhibitory effect of Anabaena sp. on in situ filtering rate of Daphnia

We found that in situ filtering rates of Daphnia spp. measured in a lake containing Anabaena were significantly lower than those measured in a filament-free lake. Even after accounting for the depressing effects of high nannoplankton biomass concentration, filtering rates in the lake with Anabaena were 64% lower than those from the filament-free lake. We also found that filtering rates for Daphnia pulex in laboratory experiments were lower when Anabaena was present in experimental beakers than when Chlorella was present. When Anabaena was removed from Three Mile Lake water, filtering rates compared closely with predicted rates based on nannoplankton concentration and carapace length alone. Our analysis indicates that the presence of Anabaena filaments depresses Daphnia grazing rates in general, and that the filaments themselves are ingested at a lower rate than algae such as Chlorella.
The effect of the organizational change on company performance mediated by changes in management accounting practices

Article history: Received March 2 2020 Received in revised format March 29 2020 Accepted April 7 2020 Available online April 7 2020 This study examines the effect of the organizational change on company performance which is mediated by changes in management accounting practices. High environmental uncertainty requires company management to make organizational changes and changes in management accounting practices to achieve performance. The study uses a survey method with a total of 1945 respondents as managers of middle to upper manufacturing companies in 389 manufacturing companies in Indonesia. Data analysis techniques use partial least square, with more accommodating considerations for analyzing complex models with various indicators that are reflective and formative. The results of the study indicate that organizational change had a positive effect on changes in management accounting practices. Changes in accounting practices have positive effects on corporate performance, and changes in management accounting practices are able to mediate environmental changes in performance. Meanwhile, organizational change does not affect the company's performance.
A survey of knowledge and variables influencing perceptions about clinical research: A cross-sectional study from Mumbai

Purpose: Clinical research in India has been besieged by controversies. While studies have addressed other stakeholders, few have addressed the patient. The present study was conducted to assess the extent of awareness and understanding about the nature and conduct of CR among people of Mumbai. Methods: Institutional Ethics Committee approval was taken (EC/OA-12/15) and written informed consent was obtained. Adults who were residents of Mumbai were enrolled. A prevalidated and published 48-item questionnaire based on six themes, namely awareness and participation, voluntariness and autonomy, compensation, confidentiality, safety, and involvement in CR were administered. Perception based on themes and association of variables such as age, gender, socioeconomic class, and education on this perception was assessed. Descriptive statistics along with Chi-square test/Chi-square test for trend and crude odds ratio (cOR) were assessed. Results: Of the 453 participants approached, 400 (age 32 [18–96]) consented. Only 210/400 (52.5%) were aware of CR and 194/400 (48.5%) said they needed permission for participation. Only 226/400 (56.5%) were aware of their rights and 111/400 (27.75%) felt that clinical trial participants received compensation. The socioeconomic class influenced awareness of CR (P < 0.00001; r2 = 0.495) as did the age (P < 0.0001; r2 = 0.82). Men were less likely to need permission to participate relative to women (cOR [95% confidence interval (CI)] 2.47 [1.6, 3.6] [P < 0.00001]). Those who had heard of CR were twice more willing to participate (cOR [95% CI] 1.72 (1.2, 2.6); P = 0.008). Conclusions: There is a greater need to improve awareness, especially about safety, compensation, and confidentiality in CR.
Exploring Discipline-Specific Vocabulary Retention in L2 through App Design: Implications for Higher Education Students

In higher education, understanding discipline-specific vocabulary can be challenging. Insufficient vocabulary can be a major challenge for students as they begin their university studies. This study examined university undergraduate English language learners’ discipline-specific vocabulary retention when they used an in-house developed mobile app, Books vs Brains@PolyU, in Hong Kong. A total of 159 second language (L2) students from four disciplines participated in the study, and they completed a pre- and posttest consisting of 120 words in four difficulty levels in their chosen disciplines. The results suggested that participants acquired more vocabulary words at the intermediate and advanced levels than at the beginner and elementary ones. The findings improve the understanding of MALL and vocabulary acquisition using apps to facilitate and support learners’ academic studies.
Penggunaan Zoom Sebagai Pembelajaran Berbasis Online Dalam Mata Kuliah Sosiologi dan Antropologi Pada Mahasiswa PPKN di STKIP Kusumanegara Jakarta

Pembelajaran online jarak jauh merupakan salah satu solusi yang dibutuhkan oleh tenaga pendidik dan mahasiswa di masa pandemi covid 19 yang terjadi pada februari 2020. Tujuan dari penelitian ini adalah untuk menggambarkan kondisi yang terjadi pada proses pembelajaran jarak jauh dengan menggunakan zoomsebagai alaternatif pemecahan masalah kegiatan pembelajaran pada mata kuliah sosiologi dan antropologi. Metode penelitian ini adalah deskriptif kualitatif dengan teknik pengumpulan data observasi, wawancara dan dokumentasi. Mandy Archibald, dkk hasil penelitiannya dengan menggunakan zoom mempermudah dalam mengumpulkan data kualitatif karena lebih efektif biaya dan kemanan terjaga.
Non‐Uniform Subdivision Surfaces with Sharp Features

Sharp features are important characteristics in surface modelling. However, it is still a significantly difficult task to create complex sharp features for Non‐Uniform Rational B‐Splines compatible subdivision surfaces. Current non‐uniform subdivision methods produce sharp features generally by setting zero knot intervals, and these sharp features may have unpleasant visual effects. In this paper, we construct a non‐uniform subdivision scheme to create complex sharp features by extending the eigen‐polyhedron technique. The new scheme allows arbitrarily specifying sharp edges in the initial mesh and generates non‐uniform cubic B‐spline curves to represent the sharp features. Experimental results demonstrate that the present method can generate visually more pleasant sharp features than other existing approaches.