Miracle-dz/UniFAR-FTUs huggingface dataset:
Household risk strategies during a pandemic – experiences from the 1918 influenza pandemic

ABSTRACT In 2020, The COVID-19 crisis has put great pressure on the economy worldwide. Only time can tell whether the COVID-19 crisis will have permanent effects on corporate and household behaviour and how it will affect society at large. This article examines historical experiences of how households managed the financial consequences of rising mortality during the 1918 influenza pandemic. We find that the previous pandemic led to an immediate and major increase in primarily small-sum industrial life insurance policies designed for blue-collar workers. The increase in new policies did not, however, have a lasting effect. By the time the pandemic had faded, the number of policies had dropped to below pre-pandemic conditions. This historical experience underlines the fact that there are limits to the extent to which even a major shock, such as a pandemic, can lead to behavioural change among households as currently being predicted in relation to COVID-19.
Evaluation of Negative Skin Friction on Bridge Abutment Piles

Piles are used to transfer loads of structures to deeper and stronger soil layers through skin friction and/or end bearing. Surcharge loads, site grading, or dewatering may induce downward movement of soil adjacent to piles installed in a compressible medium. This movement creates negative skin friction stresses acting downward at the pile-soil interface, which applies additional loads “drag forces” to the pile causing a maximum axial load in the pile shaft at the “neutral plane”. To evaluate the development of drag forces, a comprehensive field monitoring program was conducted over four years for three instrumented abutment H-piles as part of a three-span bridge project. The soil settlement and changes in pore water pressure in the soil adjacent to the piles due to the construction of an approach embankment were monitored using multiple-point extensometers and vibrating wire piezometers. The piles’ elastic settlement and strains were measured using single-point extensometers and vibrating wire strain gauges. The field measurements are presented and discussed in terms of responses time histories and load distribution along one pile shaft. In addition, the calculated forces from vibrating wire strain gauges are compared with the unified design method prediction considering the total stress method (α-method) for cohesive soils. The results show that the maximum drag force was developed after the complete dissipation of excess pore water pressure and that the location of neutral plane varied during the embankment construction stages. Employing the total stress method in the unified design method provided a reasonable prediction of the drag force and the neutral plane’s location.
Root architecture characterization in relation to biomass allocation and biological nitrogen fixation in a collection of European soybean genotypes

Soybean [Glycine max (L.) Merr] is the legume with the largest cultivated area worldwide and its yield depends largely on symbiotic nitrogen fixation and root architecture. This study aimed to explore the genetic variability of root architectural traits and di-nitrogen fixing activity in a small collection of nine European cultivars belonging to the same maturity group during their early stages. New image analysis approaches were implemented to characterise root architecture at high throughput. Significant genetic variability was identified for the width of the root system, root density, and for nitrogen fixation. This study allowed us to highlight trade-offs among root and nodule traits, and structural and functional traits. Finally, both the image analysis approach and the results could be used for breeding programs of soybean, that could take into account the root system architecture, when the plant interacts in symbiosis with N2-fixing bacteria.
Correlates of Sexual Function in a Sample of Spanish Women with Endometriosis

Background: In the present study, we aim to report on the sexual function of women experiencing symptoms of endometriosis, analysing the clinical and psychosocial factors that may be associated. Methods: A multicentre cross-sectional study was performed to analyse the sexual function in a sample of 196 Spanish women with endometriosis, using the Female Sexual Function Inventory. Results: The Female Sexual Function Inventory (FSFI) was validated in our endometriosis study group. The mean FSFI score for the sample was 22.5 (SD 6.6), with 20.9 and 26.9 being in the 25th and 75th percentiles, respectively. Although physical sexual pain and dyspareunia were factors that influenced the sexual function of women with endometriosis, our results show that the impairment was multifactorial. Conclusions: We found impaired sexual function in women diagnosed with endometriosis. The final model included deep endometriosis, depression, age, and unemployment as strongest predictive factors for poor (deteriorated) sexual function.
Printed and Digital Dictionary for Multilingual Literacy Development: A Needs Analysis

This study aimed to describe the needs analysis of the printed and digital dictionary as one of the necessary resources for developing multilingual literacy in primary education. The study applied mixed-method research with a sequential embedded design. In this study, 27 teachers and 656 students from 9 public primary schools of 9 sub-districts of Buleleng regency were involved. The questionnaires and interviews proved that both teachers and students found it necessary to master vocabulary to develop literacy. They also agreed on the importance of multilingual dictionaries, printed and digital, provided with colorful pictures to help students to learn easier. Digital dictionaries were considered more flexible, not torn, and lost. However, the observation of the libraries and teacher rooms proved that the facilities and resources are lacking in most schools. Even there were no multilingual dictionaries in English, Indonesian, and Balinese. Hence, it is recommended for further research to develop the required dictionaries. Next, teachers and students need to regularly use the dictionaries in their teaching and learning process to develop students’ multilingual literacy.
RUIZ & PAV. (ASTERACEAE)

Galinsoga quadriradiata Ruiz & Pav. is an annual weedy plant that can be found all over the world. It belongs to the Asteraceae family and is recognised as one of the invasive foreign plants in Poland, which are native to Central and South America. The aim of this study was to describe the reproductive features of Galinsoga quadriradiata focusing on the changes that occur during microsporogenesis and microgametogenesis along with the morphology of its pollen. As it is typical of the eudicot clade of Angiosperms, cytokinesis of G. quadriradiata is simultaneous. The pollen grains are tricolporate with spiny outer walls and the course of the microsporogenetic process is fairly typical of the Echinatae group of weed plants. The high viability of the pollen grains, which mature unequally in the inflorescences, and the proper course of meiosis determine whether a plant has the invasive character of Galinsoga quadriradiata.
Bisphenol A Analogues Suppress Spheroid Attachment on Human Endometrial Epithelial Cells through Modulation of Steroid Hormone Receptors Signaling Pathway

Bisphenol A (BPA) is a well-known endocrine disruptor, widely used in various consumer products and ubiquitously found in air, water, food, dust, and sewage leachates. Recently, several countries have restricted the use of BPA and replaced them with bisphenol S (BPS) and bisphenol F (BPF), which have a similar chemical structure to BPA. Compared to BPA, both BPS and BPF have weaker estrogenic effects, but their effects on human reproductive function including endometrial receptivity and embryo implantation still remain largely unknown. We used an in vitro spheroid (blastocyst surrogate) co-culture assay to investigate the effects of BPA, BPS, and BPF on spheroid attachment on human endometrial epithelial cells, and further delineated their role on steroid hormone receptor expression. We also used transcriptomics to investigate the effects of BPA, BPS, and BPF on the transcriptome of human endometrial cells. We found that bisphenol treatment in human endometrial Ishikawa cells altered estrogen receptor alpha (ERα) signaling and upregulated progesterone receptors (PR). Bisphenols suppressed spheroid attachment onto Ishikawa cells, which was reversed by the downregulation of PR through PR siRNA. Overall, we found that bisphenol compounds can affect human endometrial epithelial cell receptivity through the modulation of steroid hormone receptor function leading to impaired embryo implantation.
Race and Genetic Alterations in Prostate Cancer

Previous analyses have yielded conflicting results as to whether African American men have a higher frequency of actionable mutations and alterations in DNA repair genes. A recent study using the Genomics Evidence Neoplasia Information Exchange (GENIE) cohort did not include analysis of copy number alterations (CNAs), a dominant mechanism of cancer gene function regulation in prostate cancer. Here, we present an analysis of differences in genetic alterations, including CNAs, among men of different selfreported races with primary and metastatic prostate adenocarcinoma using the updated GENIE 8 cohort.
Audit opinion and earnings management: Empirical evidence from Vietnam

This paper aims to explore the interaction between earnings management and audit opinions in the context of Vietnam – an emerging country. For this purpose, two regressions were developed with sample consists of 1,294 firm-years in the period from 2018 to 2020. The first regression model uses Audit Opinion as dependent variable, Discretionary Accruals (DA) as independent variable, and other 8 controlling variables. The results demonstrate that the Discretionary Accruals influence audit opinion, significantly at 0.1 level in the study year. This means the auditor’s probability of issuing modified opinion is positively associated with earnings management and with the attendance of a Big 4 audit companies. Another regression model tests influence of auditor size (measured by Opinion of Auditor) on the interaction between management of earnings and audit opinion (measured by Discretionary Accruals) as independent variable, and other 10 controlling variables. Surprisingly, this model is not statistically significant and this confirms that the appearance of a Big 4 audit companies does not significantly affect the nexus between profit management and audit opinion in the case of Vietnamese listed companies. The results suggest that Big 4 audit firms tend to have higher requirements for the true-and-fair information on the client’s financial statements and often have a tendency to issue modified opinions when the financial statements have material errors, or it is impossible to collect sufficient audit evidence. This finding may enhance the decision-making process of users in various circumstances. AcknowledgmentsThis paper is funded by the National Economics University (NEU), Vietnam. The authors thank anonymous reviewers for their contributions and the NEU for supporting this study.
Efficient Data-Mining Algorithm for Predicting Heart Disease Based on an Angiographic Test

Background The computerised classification and prediction of heart disease can be useful for medical personnel for the purpose of fast diagnosis with accurate results. This study presents an efficient classification method for predicting heart disease using a data-mining algorithm. Methods The algorithm utilises the weighted support vector machine method for efficient classification of heart disease based on a binary response that indicates the presence or absence of heart disease as the result of an angiographic test. The optimal values of the support vector machine and the Radial Basis Function kernel parameters for the heart disease classification were determined via a 10-fold cross-validation method. The heart disease data was partitioned into training and testing sets using different percentages of the splitting ratio. Each of the training sets was used in training the classification method while the predictive power of the method was evaluated on each of the test sets using the Monte-Carlo cross-validation resampling technique. The effect of different percentages of the splitting ratio on the method was also observed. Results The misclassification error rate was used to compare the performance of the method with three selected machine learning methods and was observed that the proposed method performs best over others in all cases considered. Conclusion Finally, the results illustrate that the classification algorithm presented can effectively predict the heart disease status of an individual based on the results of an angiographic test.
Role and Function of O-GlcNAcylation in Cancer

Simple Summary Despite the rapid advancement in immunotherapy and targeted agents, many patients diagnosed with cancer have poor prognosis with dismal overall survival. One of the key hallmarks of cancer is the ability of cancer cells to reprogram their energy metabolism. O-GlcNAcylation is an emerging potential mechanism for cancer cells to induce proliferation and progression of tumor cells and resistance to chemotherapy. This review summarizes the mechanism behind O-GlcNAcylation and discusses the role of O-GlcNAcylation, including its function with receptor tyrosine kinase and chemo-resistance in cancer, and immune response to cancer and as a prognostic factor. Further pre-clinical studies on O-GlcNAcylation are warranted to assess the clinical efficacy of agents targeting O-GlcNAcylation. Abstract Cancer cells are able to reprogram their glucose metabolism and retain energy via glycolysis even under aerobic conditions. They activate the hexosamine biosynthetic pathway (HBP), and the complex interplay of O-linked N-acetylglucosaminylation (O-GlcNAcylation) via deprivation of nutrients or increase in cellular stress results in the proliferation, progression, and metastasis of cancer cells. Notably, cancer is one of the emerging diseases associated with O-GlcNAcylation. In this review, we summarize studies that delineate the role of O-GlcNAcylation in cancer, including its modulation in metastasis, function with receptor tyrosine kinases, and resistance to chemotherapeutic agents, such as cisplatin. In addition, we discuss the function of O-GlcNAcylation in eliciting immune responses associated with immune surveillance in the tumor microenvironment. O-GlcNAcylation is increasingly accepted as one of the key players involved in the activation and differentiation of T cells and macrophages. Finally, we discuss the prognostic role of O-GlcNAcylation and potential therapeutic agents such as O-linked β-N-acetylglucosamine-transferase inhibitors, which may help overcome the resistance mechanism associated with the reprogramming of glucose metabolism.
Predicting the Photosynthetic Rate of Chinese Brassica Using Deep Learning Methods

Water stress is a significant element impacting photosynthesis, which is one of the major physiological activities governing crop growth and development. In this study, the photosynthetic rate of Brassica chinensis L. var. parachinensis (Bailey) (referred to as Chinese Brassica hereafter) was predicted using the deep learning method. Five sets of Chinese Brassica were created, each with a different water stress gradient. Air temperature (Ta), relative humidity (RH), canopy temperature (Tc), transpiration rate (Tr), photosynthetic rate (Pn), and photosynthetically available radiation (PAR) were measured in different growth stages. The upper limit and lower limit equations were built using the non-water-stress baseline (NWSB) and hierarchical density-based spatial clustering of applications with noise (HDBSCAN) methods. The crop water stress index (CWSI) was then calculated using these built equations. The multivariate long short-term memory (MLSTM) model was proposed to predict Pn based on CWSI and other parameters. At the same time, the support vector regression (SVR) method was applied to provide a comparison to the MSLTM model. The results show that water stress had an important effect on the growth of Chinese Brassica. The more serious the water stress, the lower the growth range (GR). The HDBSCAN method had a lower root mean square error (RMSE) in calculating CWSI. Furthermore, the CWSI had a significant effect on predicting Pn. The regression fitting between measured Pn and predicted Pn showed that the determination coefficient (R2) and RMSE were 0.899 and 0.108 μmol·m−2·s−1, respectively. In this study, we successfully developed a method for the reliable prediction of Pn in Chinese Brassica, which can serve as a useful reference for application in water saving.
Hemodynamic features underlying pulmonary vein stump thrombus formation after left upper lobectomy: four-dimensional flow magnetic resonance imaging study.

Background We previously reported that to-and-fro blood movement near the pulmonary vein stump was particularly prominent after left upper lobectomy compared with other lobectomy, which may be the cause of the high susceptibility of pulmonary vein thrombus after left upper lobectomy. The aim of the present study was to compare the hemodynamics in patients who developed pulmonary vein thrombus after left upper lobectomy with those in patients who did not develop pulmonary vein thrombus using four-dimensional flow magnetic resonance imaging (4D MRI). Methods This was a retrospective evaluation of a prospectively collected clinical and radiological database of 37 patients who underwent 4D MRI 7 days after left upper lobectomy for lung cancer (n=37). We obtained two parameters by 4D MRI: the grade of to-and-fro blood movement and the flow energy loss around the pulmonary vein stump. The length of the pulmonary vein stump, a known risk factor for pulmonary vein thrombus, was also measured. Results According to a scatterplot of the grade of to-and-fro blood movement versus the flow energy loss, patients with pulmonary vein thrombus (n=15) were concentrated in an area which appears to be a 'dangerous' hemodynamic condition. There were few patients without pulmonary vein thrombus in this 'dangerous' area, except for one who unfortunately developed delayed pulmonary vein thrombus and cerebral infarction. We proposed a formula using the 4D MRI-derived parameters based on a stepwise multiple regression analysis that was more closely associated with the development of pulmonary vein thrombus than the length of the pulmonary vein stump (area under the receiver operating characteristics curve: 0.918 vs. 0.705, P=0.0500). Conclusions We proposed the existence of a 'dangerous' hemodynamic condition responsible for pulmonary vein thrombus formation. 4D MRI before the development of pulmonary vein thrombus may help identify patients requiring preventive therapy against pulmonary vein thrombus and subsequent thromboembolic complications.
Experimental design and biometric research. Toward innovations

: This chapter deals with the approach of “within subjects” and focuses on single hypothesis testing. Both parametrical and non-parametrical versions are described. Every test is introduced, and the full step-by-step SPSS guidance is presented. The sections about effect size and about writing the report are included as well.
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock

The biomechanical environment plays a key role in regulating cartilage formation, but current understanding of mechanotransduction pathways in chondrogenic cells is incomplete. Amongst the combination of external factors that control chondrogenesis are temporal cues that are governed by the cell-autonomous circadian clock. However, mechanical stimulation has not yet directly been proven to modulate chondrogenesis via entraining the circadian clock in chondroprogenitor cells. The purpose of this study was to establish whether mechanical stimuli entrain the core clock in chondrogenic cells, and whether augmented chondrogenesis caused by mechanical loading was at least partially mediated by the synchronised, rhythmic expression of the core circadian clock genes, chondrogenic transcription factors, and cartilage matrix constituents at both transcript and protein levels. We report here, for the first time, that cyclic uniaxial mechanical load applied for 1 hour for a period of 6 days entrains the molecular clockwork in chondroprogenitor cells during chondrogenesis in limb bud-derived micromass cultures. In addition to the several core clock genes and proteins, the chondrogenic markers SOX9 and ACAN also followed a robust sinusoidal rhythmic expression pattern. These rhythmic conditions significantly enhanced cartilage matrix production and upregulated marker gene expression. The observed chondrogenesis-promoting effect of the mechanical environment was at least partially attributable to its entraining effect on the molecular clockwork, as co-application of the small molecule clock modulator longdaysin attenuated the stimulatory effects of mechanical load. This study suggest that an optimal biomechanical environment enhances tissue homeostasis and histogenesis during chondrogenesis at least partially through entraining the molecular clockwork.
The Role of 20-HETE, COX, Thromboxane Receptors, and Blood Plasma Antioxidant Status in Vascular Relaxation of Copper-Nanoparticle-Fed WKY Rats

Recently, the addition of copper nanoparticles (NPs) in a daily diet (6.5 mg/kg) was studied in different animal models as a possible alternative to ionic forms. Male Wistar–Kyoto rats (24-week-old, n = 11) were fed with copper, either in the form of carbonate salt (Cu6.5) or metal-based copper NPs (NP6.5), for 8 weeks. The third group was fed with a half dose of each (NP3.25 + Cu3.25). The thoracic aorta and blood plasma was studied. Supplementation with NP6.5 decreased the Cu (×0.7), Cu/Zn-ratio (×0.6) and catalase (CAT, ×0.7), and increased Zn (×1.2) and superoxide dismutase (SOD, ×1.4). Meanwhile, NP3.25 + Cu3.25 decreased the Cu/Zn-ratio (×0.7), and CAT (×0.7), and increased the daily feed intake (×1.06). Preincubation with either the selective cyclooxygenase (COX)-2 inhibitor, or the non-selective COX-1/2 inhibitor attenuated vasodilation of rat thoracic aorta in the NP6.5 group exclusively. However, an increased vasodilator response was observed in the NP6.5 and NP3.25 + Cu3.25 group of rats after preincubation with an inhibitor of 20-hydroxyeicosatetraenoic acid (20-HETE) formation, and the thromboxane receptor (TP) antagonist. Significant differences were observed between the NP6.5 and NP3.25 + Cu3.25 groups of rats in: dietary intake, acetylcholine-induced vasodilation, and response to COX-inhibitors. Copper NPs in a standard daily dose had more significant effects on the mechanism(s) responsible for the utilization of reactive oxygen species in the blood plasma with the participation of prostanoids derived from COX-2 in the vascular relaxation. Dietary copper NPs in both doses modified vasodilation through the vasoconstrictor 20-HETE and the TP receptors.