Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Perioperative Fluid Balance on Postoperative Complications after Esophagectomy for Esophageal Cancer

Background: Perioperative fluid balance is an important indicator in the management of esophageal cancer patients who undergo esophagectomy. However, the association between perioperative fluid balance and postoperative complications after minimally invasive esophagectomy (MIE) remains unclear. Methods: This study included 115 patients with thoracic esophageal squamous cell cancer who underwent MIE between January 2018 and January 2020. We retrospectively evaluated the association between perioperative fluid balance from during surgery to postoperative day (POD) 2, and postoperative complications. Results: The patients were divided into lower group and higher group based on the median fluid balance during surgery and at POD 1 and POD 2. We found that the higher group at POD 1 (≥3000 mL) was the most important indicator of postoperative complications, such as acute pneumonia within 7 days after surgery, and anastomotic leakage (p = 0.029, p = 0.024, respectively). Moreover, the higher group at POD 1 was a significant independent factor for acute postoperative pneumonia by multivariate analysis (OR: 3.270, 95% CI: 1.077–9.929, p = 0.037). Conclusion: This study showed that fluid overload at POD 1 had a negative influence on postoperative complications in patients with esophageal cancer. The fluid balance must be strictly controlled during the early postoperative management of patients undergoing esophageal cancer surgery.
Design, Spectroscopy, and Assessment of Cholinesterase Inhibition and Antimicrobial Activities of Novel Coumarin–Thiadiazole Hybrids

A novel series of coumarin–thiadiazole hybrids, derived from substituted coumarin-3-carboxylic acids was isolated and fully characterized with the use of a number of spectroscopic techniques and XRD crystallography. Several of the novel compounds showed intensive fluorescence in the visible region, comparable to that of known coumarin-based fluorescence standards. Moreover, the new compounds were tested as potential antineurodegenerative agents via their ability to act as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. Compared to the commercial standards, only a few compounds demonstrated moderate AChE and BuChE activities. Moreover, the novel derivatives were tested for their antimicrobial activity against a panel of pathogenic bacterial and fungal species. Their lack of activity and toxicity across a broad range of biochemical assays, together with the exceptional emission of some hybrid molecules, highlights the possible use of a number of the novel hybrids as potential fluorescence standards or fluorescence imaging agents.
Outcomes in adults with cerebral palsy: systematic review using the International Classification of Functioning, Disability and Health

In the context of the development of an International Classification of Functioning, Disability and Health (ICF) Core Set for adults with cerebral palsy (CP), this systematic review sought to identify the outcome measures used in studies on adults with CP, to examine their content using the ICF as a reference, and to demonstrate the most studied areas in this population.
Nexilin is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation.

BACKGROUND Membrane contact sites (MCS) are fundamental for transmission and translation of signals in multicellular organisms. A prime example is junctional membrane complexes (JMC) in the cardiac dyads, where T-tubules are juxtaposed to the sarcoplasmic reticulum (SR). T-tubule uncoupling and remodeling are well-known features of cardiac disease and heart failure. Even subtle alterations in the association between T-tubules and the Junctional SR can cause serious cardiac disorders. Nexilin (NEXN) has been identified as an actin-binding protein and multiple mutations in the NEXN gene are associated with cardiac diseases, but the precise role of NEXN in heart function and disease is still unknown. METHODS Nexn global and cardiomyocyte specific KO mice were generated. Comprehensive phenotypic and RNA-seq and mass spectrometry analyses were performed. Heart tissue samples and isolated single cardiomyocytes were analyzed by electron and confocal microscopy. RESULTS Global and cardiomyocyte specific loss of Nexn in mice resulted in a rapidly progressive dilated cardiomyopathy. In vivo and in vitro analyses revealed that NEXN interacted with junctional SR proteins, was essential for optimal calcium transients, and was required for initiation of T-tubule invagination and formation. CONCLUSIONS These results demonstrated that NEXN is a pivotal component of the JMC, and is required for initiation and formation of T-tubules, thus providing insight into mechanisms underlying cardiomyopathy in patients with mutations in NEXN.
Three Decades of Research on Induced Hypocrisy: A Meta-Analysis

Induced hypocrisy is a sequential, two-step, cognitive dissonance procedure that prompts individuals to adopt a proattitudinal behavior. The present meta-analysis of 29 published and nine unpublished induced-hypocrisy studies enabled us to test three key dissonance-related issues. First, is hypocrisy effective in promoting change in behavioral intention and behavior? Our analyses supported the idea that hypocrisy (vs. control) increased both behavioral intention and behavior. Second, does hypocrisy generate psychological discomfort? Results pertaining to this issue were inconclusive due to the small number of studies measuring psychological discomfort. Third, are both steps necessary to generate change? Effect sizes conform to the idea that the transgressions-only condition can increase both behavior and intention. Our meta-analysis raises a number of theoretical issues concerning the psychological processes underlying induced hypocrisy and highlights implications for practitioners.
Tspan8 is expressed in breast cancer and regulates E‐cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles

Tspan8 exhibits a functional role in many cancer types including pancreatic, colorectal, oesophagus carcinoma, and melanoma. We present a first study on the expression and function of Tspan8 in breast cancer. Tspan8 protein was present in the majority of human primary breast cancer lesions and metastases in the brain, bone, lung, and liver. In a syngeneic rat breast cancer model, Tspan8+ tumours formed multiple liver and spleen metastases, while Tspan8− tumours exhibited a significantly diminished ability to metastasise, indicating a role of Tspan8 in metastases. Addressing the underlying molecular mechanisms, we discovered that Tspan8 can mediate up‐regulation of E‐cadherin and down‐regulation of Twist, p120‐catenin, and β‐catenin target genes accompanied by the change of cell phenotype, resembling the mesenchymal–epithelial transition. Furthermore, Tspan8+ cells exhibited enhanced cell–cell adhesion, diminished motility, and decreased sensitivity to irradiation. As a regulator of the content and function of extracellular vesicles (EVs), Tspan8 mediated a several‐fold increase in EV number in cell culture and the circulation of tumour‐bearing animals. We observed increased protein levels of E‐cadherin and p120‐catenin in these EVs; furthermore, Tspan8 and p120‐catenin were co‐immunoprecipitated, indicating that they may interact with each other. Altogether, our findings show the presence of Tspan8 in breast cancer primary lesion and metastases and indicate its role as a regulator of cell behaviour and EV release in breast cancer. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
A Novel SLAM Method Using Wi-Fi Signal Strength and RGB-D Images

With the widespread deployment of Wi-Fi access points (APs), the Wi-Fi has become a promising means for Simultaneous Localization and Mapping (SLAM). Benefited from the wide coverage of Wi-Fi, the Wi-Fi signal can be used for large-scale SLAM. Therefore, a SLAM method using the Wi-Fi signal strength to estimate the location of the robot and the Wi-Fi APs based on Extended Karman Filter (EKF)is proposed. However, influenced by the noise of the measurement of Wi-Fi signal strength, it is hard to achieve an accurate result in SLAM which only relies on the Wi-Fi signal strength measurement. To improve the accuracy of the SLAM, a fusion of the Wi-Fi signal strength and the RGB-D images is needed. Therefore, we propose a novel SLAM method using both the Wi-Fi signal strength and the RGB-D images, which consists of the EKF and the graph-optimization. The EKF part employs the Wi-Fi signal strength information to estimate the pose of the robot and the locations of the APs, and the graph-optimization part employs the RGB-D images to estimate poses of the robot. The experiments prove that our method achieves a better localization and mapping result than traditional RGB-D SLAM methods, especially improves the robustness of the SLAM system.
Capuchin monkeys (Sapajus [Cebus] apella) play Nash equilibria in dynamic games, but their decisions are likely not influenced by oxytocin

Comparative approaches to experimental economics have shed light on the evolution of social decision‐making across a range of primate species, including humans. Here we replicate our previous work looking at six pairs of capuchin monkeys' (Sapajus [Cebus] apella) responses to scenarios requiring both coordination (Assurance Game) and anti‐coordination (Hawk‐Dove Game). This then provides a foundation for assessing their responses to two additional games, one with a scenario of beneficial cooperation with a temptation to defect (Prisoner's Dilemma) and one with an environment requiring changing strategies within short temporal proximity (Alternating Economic Game). We additionally explored the effects of exogenous oxytocin on decision‐making. Oxytocin did not affect decisions in any of our games. Results from the first two games largely replicated our previous findings. Responses to the Prisoner's Dilemma were more varied than was seen in previous games, with pairs respectively cooperating, defecting, and failing to establish stable strategies. Such variability indicates that this game may be a good assay for individual differences in social decision‐making. Finally, capuchins were able to flexibly switch between their previously established strategies within each of the different games, even when the games were presented within the same session, requiring strategy adjustments within short temporal proximity. These results build on earlier findings showing that capuchins can alter decision‐making strategies as the context demands, which is likely essential for decision‐making in naturally occurring contexts.
On the spectrum bo ∧ tmf

M. Mahowald, in his work on bo-resolutions, constructed a bomodule splitting of the spectrum bo ∧ bo into a wedge of summands related to integral Brown-Gitler spectra. In this paper, a similar splitting of bo ∧ tmf is constructed. This splitting is then used to understand the bo∗-algebra structure of bo∗tmf and allows for a description of bo∗tmf.
Concept cartoon in problem-based learning : A systematic literature review analysis

Concept cartoon teaching strategy have the potential to increase creativity and innovation as well as the students' interest in understanding concepts. It is considered as a method that encourages students to continue exploring the issues raised and seeking solutions. This concept cartoon lesson is very suitable to be applied in the field of Science, Technology, Engineering and Mathematics which is often regarded as an abstract and difficult field. Therefore, it is becoming a necessity to see how far the cartoon concept in learning has been implemented in schools. This systematic literature review analysis aims to focus on the similarities and differences such as the objective used, the methodology used and the findings of the study. The study article was selected through a database of various types of journals according to keywords. Keywords used in the search are Concept Cartoon AND comic AND Problem-based learning. The search has been limited between 2009 and 2017. A total of 9 studies have been selected to be analyzed based on the four steps in systematic literature review. The four steps included frame a question, run a search, read the abstract and tittle of individual papers and abstract information from selected set of final articles. The results of the systematic literature review analysis can be concluded on recent research and previous research that cartoon concept teaching strategy is very effective in enhancing creative thinking as well as cultivating students' interest in Science, Technology, Engineering and Mathematics.
A New Rabbit Model of Chronic Dry Eye Disease Induced by Complete Surgical Dacryoadenectomy

ABSTRACT Purpose/Aim: Dry eye disease (DED), common and suboptimally treated, is in need of novel animal models to understand its pathophysiology and assess the efficacy and other parameters of new pharmacological agents for its treatment. The more than 10 rabbit models of DED described to date have significant limitations including induction of mild disease, lack of consistency, and off-target effects when chemical agents are used for disease induction. Our aim was to develop a new model of chronic DED in rabbits that overcomes the limitations of existing models. Materials and Methods: We performed a complete surgical resection of all orbital lacrimal glands (LGs; dacryoadenectomy) in normal adult New Zealand White rabbits. One week after removal of the nictitating membrane, we surgically removed the orbital superior LG, followed by removal of the palpebral superior LG, and finally removal of the inferior LG. Surgery was performed under anesthesia, required about 1 h/eye, and was well-tolerated. Results: Dacryoadenectomy induced severe DED, evidenced by >90% reduction in the tear break up time test, 50% reduction in the Schirmer tear test, 10% increase in tear osmolarity, and a marked increase in the rose bengal staining score. DED was sustained and essentially unchanged for the eight weeks of observation. Sham-operated rabbits showed no such changes, with the exception of a non-significant and transient reduction in the tear break up time test, a response to ocular surgery. Conclusions: This model of stable, chronic, predominantly aqueous-deficient DED recapitulates key clinical and histological features of human DED and is suitable for the study of ocular surface homeostasis, of the pathophysiology of DED, and of the efficacy of candidate drugs for DED treatment.
The Bioconcentration and the Translocation of Heavy Metals in Recently Consumed Salicornia ramosissima J. Woods in Highly Contaminated Estuary Marshes and Its Food Risk

Salicornia species are halophyte plants that are an important source for food, pharmacy, and bioenergy. They can be consumed as a leafy vegetable, but they can accumulate heavy metals that carry a health risk when knowledge of how each species behaves in different types of soil is lacking. This present work aimed to determine to what extent S. ramosissima can be cultivated as food in estuaries contaminated by heavy metals and to what extent it can be used in phytoremediation works, by studying its behavior in populations that grow naturally in contaminated soils. We analyzed accumulation and translocation in different parts of the plant for 14 heavy metals and calculated the Health Risk Index value associated with their consumption as a leafy vegetable. The results obtained mean that the S. ramosissima plants that grow in most of the soils of this estuary are unfit for human consumption in some of the populations studied. In conclusion, Salicornia ramosissima J. Woods can accumulate Cd, As, and Pb—among other metals—in its leaves so its consumption should be limited to plants that grow in soils free of these metals.
Mechanisms Driving the Emergence of Neuronal Hyperexcitability in Fragile X Syndrome

Hyperexcitability is a shared neurophysiological phenotype across various genetic neurodevelopmental disorders, including Fragile X syndrome (FXS). Several patient symptoms are associated with hyperexcitability, but a puzzling feature is that their onset is often delayed until their second and third year of life. It remains unclear how and why hyperexcitability emerges in neurodevelopmental disorders. FXS is caused by the loss of FMRP, an RNA-binding protein which has many critical roles including protein synthesis-dependent and independent regulation of ion channels and receptors, as well as global regulation of protein synthesis. Here, we discussed recent literature uncovering novel mechanisms that may drive the progressive onset of hyperexcitability in the FXS brain. We discussed in detail how recent publications have highlighted defects in homeostatic plasticity, providing new insight on the FXS brain and suggest pharmacotherapeutic strategies in FXS and other neurodevelopmental disorders.
A Low-Dose 4F-PCC Protocol for DOAC-Associated Intracranial Hemorrhage

Purpose: Current guidelines favor 4F-PCC over plasma for reversal of warfarin. Uncertainty remains on the hemostatic effectiveness and thrombotic risk of 4F-PCC for direct-acting oral anticoagulants (DOACs), particularly in patients with intracranial hemorrhage (ICH). This study sought to evaluate the effectiveness and safety of a lower dose protocol of 25 units/kg 4F-PCC for the management of DOAC-associated ICH in a real-world setting. Materials and Methods: This was a retrospective study of adult patients who received at least one dose of 4F-PCC from March 2014 to December 2015 for DOAC-associated ICH. The primary outcome was hemostatic effectiveness within 24 hours. The secondary outcome was thromboembolic events within 14 days. Results: Twenty-two patients received 4F-PCC for DOAC-associated ICH and were included in the analysis. Hemostasis was evaluable in 19 patients with post-4F-PCC imaging available and occurred in 18/19 (94.7%) patients. Thromboembolism occurred in 2 out of 22 patients (9.1%). Conclusions: The use of a lower dose protocol of 25 units/kg of 4F-PCC resulted in high rates of hemostasis in patients with DOAC-associated ICH. Two patients developed thrombotic events within 14 days of 4F-PCC administration.
Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway

Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by impairments of cognitive function as a result of synaptic deficits and neuronal loss, is associated with inflammation. Apelin-13, a predominant neuropeptide with inhibiting effect on inflammation, has beneficial effects on cognition memory and neuronal damage. However, whether apelin-13 can protect neurons to ameliorate cognitive deficits in AD by inhibiting the inflammatory response remains largely unknown. To test this hypothesis, rats were intracerebroventricularly (ICV) injected with streptozotocin (3 mg/kg) alone or in combination with apelin-13 (2 μg). And tyrosine receptor kinase B (TrkB) blocker K252a (200 nM) was administrated 10 min before apelin injection. Furthermore, cognitive performance was assessed by new object recognition (NOR) and Y-maze tests. Protein expression of apelin, APJ, microglial marker (IBA1), astroglia marker (GFAP), interleukin 1 beta (IL-1β), tumor necrosis factor-α (TNF-α), synaptophysin (SYP), brain-derived neurotrophic factor (BDNF), TrkB, phospho-TrkB (p-TrkB) in the hippocampus were examined by western blotting or immunohistochemistry. And the gene expression of IBA1, GFAP, IL-1β, TNF-α, and SYP were detected by real-time quantitative polymerase chain reaction (PCR). Inflammatory disorder in the hippocampus was tested by hematoxylin and eosin (H&E) staining. The enzyme-linked immunosorbent assay (ELISA) was used to study the expression level of acetylcholine. And the activity of acetylcholinesterase was detected by Acetylcholinesterase Assay Kit. We observed that apelin/APJ signaling was downregulated in the hippocampus of rats administrated with STZ. Apelin-13 was found to significantly ameliorate STZ-induced AD-like phenotypes including congnitive deficit, cholinergic disfunction and the damage of neuron and synaptic plasticity. Moreover, apelin-13 inhibited microglia and astrocyte activation, reduced IL-1β and TNF-α expression and hippocampal BDNF/TrkB expression deficit in AD rats. Finally, apelin-13-mediated effects were blocked by TrkB receptor antagonist K252a. These results suggest that apelin-13 upregulates BDNF/TrkB pathway against cognitive deficit in a STZ-induced rat model of sporadic AD by attenuating inflammation.
YIELD, YIELD COMPONENTS AND OIL RATIOS OF IRRIGATED AND RAINFED SAFFLOWER CULTIVARS (CARTHAMUS TINCTORIUS L.) UNDER SEMI-ARID CLIMATE CONDITIONS

The field experiment was conducted in the experimental area of the Faculty of Agriculture in Harran University during of 2019-20, 2020-21 growing seasons to determine the yield and yield components of some safflower cultivars under irrigated and rainfed conditions. The experimental layout was divided into plots in randomized block desing with three replicates. Five safflower varieties (Göktürk, Koç, Dinçer, Safir and Balcı) were used as the plant material. Plant height (cm), number of lateral branches (number plant -1 ), number of capitula (capitula plant -1 ), number of seeds per capitulum (number capitulum -1 ), 1000-seed weight (g), seed yield (kg ha -1 ), crown yield (g), crude oil content (%) and crude oil yield (kg ha -1 ) were investigated. Yields of irrigated cultivars (2425.8 and 2308.9 kg ha -1 ) in both years were higher than those grown under rainfed conditions (857.3 and 578.1 kg ha -1 ). The best performance under rainfed conditions was obtained from Dinçer cultivar, and the performance of Dinçer and Balci cultivars under irrigated conditions were better than of other three cultivars. In addition, oil content of varieties grown under irrigation were higher than varieties grown under rainfed conditions. Balcı variety had the highest oil content and best performance under rainfed and irrigated conditions for oil content.
Cartilage Homeostasis and Osteoarthritis

Healthy limb joints are important for maintaining health and attaining longevity. Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal development) is essential for bone formation, especially in long-axis bones. In contrast to endochondral ossification, chondrocyte populations in articular cartilage persist and maintain joint tissue into adulthood. Articular cartilage, a connective tissue consisting of chondrocytes and their surrounding extracellular matrices, plays an essential role in the mechanical cushioning of joints in postnatal locomotion. Osteoarthritis (OA) pathology relates to disruptions in the balance between anabolic and catabolic signals, that is, the loss of chondrocyte homeostasis due to aging or overuse of cartilages. The onset of OA increases with age, shortening a person’s healthy life expectancy. Although many people with OA experience pain, the mainstay of treatment is symptomatic therapy, and no fundamental treatment has yet been established. To establish regenerative or preventative therapies for cartilage diseases, further understanding of the mechanisms of cartilage development, morphosis, and homeostasis is required. In this review, we describe the general development of cartilage and OA pathology, followed by a discussion on anabolic and catabolic signals in cartilage homeostasis, mainly microRNAs.