Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-Ferroics With Polarization in Laminate Composites

Abstract : It has been discovered that laminate composites of longitudinally magnetized magnetostrictive and transversely poled piezoelectric layers (a L-T laminate composite) have a giant magneto-electric (ME) effect under a low magnetic bias. The ME voltage coefficient is over 110 mV/Oe at a magnetic bias H=500 Oe. This value is 5-10 times higher than that previously reported for transverse magnetized/ transverse polarized (T-T) laminates of the same layer compositions at the same bias. In this paper, we also report the magneto-elasto-electric bi-effect equivalent circuit of the L-T laminate composite and the corresponding theoretical formula of the magneto-electric voltage coefficient.
YouTube as a source of information for pressure injury: Quality assessment and content analysis

Abstract We aimed to assess the quality and reliability of pressure injury‐related videos uploaded on YouTube, analyse the sources and contents, and examine the correlation between video parameters. We searched YouTube using two keywords, “pressure ulcer” and “pressure sore”, on August 20, 2022. We sorted the videos according to their number of views and included the top 100 videos for each keyword. The quality of videos was assessed using the Global Quality Scale (GQS), while their reliability was evaluated by the modified DISCERN (mDISCERN) tool. In addition, we evaluated the videos in which content was included, analysed the correlations and differences between GQS, mDISCERN, and video parameters. We initially found a total of 100 videos for each keyword and finally included and analysed 77 videos. The mean scores for the mDISCERN and GQS were 2.35 ± 0.98 and 3.09 ± 0.99, respectively. Both GQS and mDISCERN showed statistically significant correlations with each other (rho = 0.54, p < 0.0001*) and with the length of the videos, respectively (rho = 0.36, p = 0.001*), (rho = 0.29, p = 0.01*). Of the videos created by physicians, 8 (57.1%) included content related to treatment, while of the videos created by nonphysician health personnel, 22 (57.9%) included content related to prevention. Analysing whether there were differences in video parameters based on the sources, we observed significant differences between sources in GQS (p < 0.0001*), mDISCERN (p < 0.0001*), and video length (p = 0.001*). In the post‐hoc analysis, videos uploaded by physicians or nonphysician health personnel showed higher quality and reliability than videos uploaded by other sources. Therefore, the results of this study could be useful for healthcare providers, as well as patients and caregivers, to search for high‐quality and reliable YouTube videos related to pressure injury.
The association between natural braces and the development of bark-included junctions in trees

Abstract Bark-included junctions are a malformation that occur in a wide range of tree species. Although the formation of an acute internal angle at a branch junction has been suggested as the primary cause of bark-included junctions in trees, it is logical to assume that a weak structure of this kind may develop under a much lower loading regime than that of a normally formed junction. One factor that would affect the mechanical loading of a junction is the presence of crossing or touching limbs that are situated above such a junction and that act as a ‘natural brace’ that straddles the join, thus restricting the natural movement of the junction and its associated limbs. Survey and analysis of data from a cohort of broadleaved trees identified a very strong association (93.9%) between bark-included junctions that exhibited no discernible bulging (n = 99) and the presence of one or more natural brace above those junctions. Additionally, the bark-included junctions that exhibited a major bulge (n = 30) were significantly associated with the absence of natural braces (93.3%). This finding has several important ramifications for professional tree surgery operations and tree surveying techniques, which will be the subject of a companion paper.
High resolution water body mapping for SWAT evaporative modelling in the Upper Oconee watershed of Georgia, USA

Technological improvements in remote sensing and geographic information systems have demonstrated the abundance of artificially constructed water bodies across the landscape. Although research has shown the ubiquity of small ponds globally, and in the southeastern United States in particular, their cumulative impact in terms of evaporative alteration is less well quantified. The objectives of this study are to examine the hydrologic and evaporative importance of small artificial water bodies in the Upper Oconee watershed in the northern Georgia Piedmont, USA, by mapping their locations and modelling these small reservoirs using the Soil Water Assessment Tool. Comparative Soil Water Assessment Tool models were run with and without the inclusion of small reservoir surface area and volume. The models used meteorological inputs from 1990–2013 to represent years with drought, high precipitation, and moderate precipitation for both the calibration and evaluation periods. Statistical comparison of streamflow indicated that the calibration methodology produced results where the default model simulation without reservoirs fit observed flows more closely than the modified model with small reservoirs included (e.g., Nash–Sutcliffe efficiency of 0.72 vs. 0.64, r2 of 0.73 vs. 0.66, and percent bias of 11.4 vs. 21.6). In addition, Penman–Monteith, Hargreaves, and Priestley–Taylor evapotranspiration equations were used to estimate actual evaporation from 2,219 small water bodies identified throughout the 1,936.8 km2 watershed. Depending on the evaporation equation used, water bodies evaporated an average of 0.03–0.036 km3/year for the period 2003–2013. Using Penman–Monteith further, if the reservoirs were not considered and average actual evapotranspiration rates from the rest of the basin were applied, only 0.016 km3 of water would have left the basin as a result of evapotranspiration. This finding suggests construction of small reservoirs increased evaporation by an average of 0.017 km3 per year (approximately 46,500 m3/day). As the construction of small reservoirs continues and high resolution image data used to map these water bodies becomes increasingly available, watershed models that evolve to address the cumulative impacts of small water bodies on evaporation and other hydrologic processes will have greater potential to benefit the water resource management community.
Advances in understanding bat infection dynamics across biological scales

Over the past two decades, research on bat-associated microbes such as viruses, bacteria and fungi has dramatically increased. Here, we synthesize themes from a conference symposium focused on advances in the research of bats and their microbes, including physiological, immunological, ecological and epidemiological research that has improved our understanding of bat infection dynamics at multiple biological scales. We first present metrics for measuring individual bat responses to infection and challenges associated with using these metrics. We next discuss infection dynamics within bat populations of the same species, before introducing complexities that arise in multi-species communities of bats, humans and/or livestock. Finally, we outline critical gaps and opportunities for future interdisciplinary work on topics involving bats and their microbes.
Professional Learning Communities’ role in high school teachers’ professional learning at a private school in the Western Cape

Education is seen by most governments as an area that must be highly regulated and prescribed to serve national interests. Consequently, top-down professional development programmes have become the norm. This highly prescriptive environment threatens to diminish teacher professionalism, and at the same time, struggles to deliver effective career-long teacher professional learning or improved learner achievement because uniformity of knowledge is assumed when the aim is the transmission or transfer of knowledge and internalization. Such a situation does not serve the multifarious contexts and needs that exist in our schools today. Career-long professional learning is commonly advocated for in-service teachers and this case study intended to show that Professional Learning Communities (PLCs), as seen through the lens of activity theory, could serve those learning needs well. Teachers’ classroom practice and professionalism have regularly been mentioned in publications since 1990 and the literature suggests that professional learning through participation plays a crucial role in both of these. The objective of this research study was thus to explore how the participants learn and to discover the gap between current learning practices and the potential for professional learning in a Professional Learning Community. Positioned within qualitative research, this single case study design viewed Professional Development in Education through the lens of Y. Engeström’s (1987) activity theory, which propounds a cultural historical approach to learning in which teachers see themselves as one, constantly transforming point of an integrated system of learning. A constructivist paradigm thus guided data collection and analysis. Seven teachers who had exhibited an active interest in independent professional learning and development were selected through purposive sampling. Data were collected through semi-structured interviews, a focus group discussion and four questionnaires. Data were analysed by coding themes, which formed the basis of this case study’s findings and recommendations. Prior to theme development, the definitions of key terms were clarified to reflect the constructivist paradigm of this case study The following key findings were revealed by the data.  There was paradigmatic dissonance between the three educational activity systems, namely the national government DBE, the provincial WCED and the school. Stellenbosch University https://scholar.sun.ac.za
Prebiotics counteract the morphological and functional changes secondary to chronic cisplatin exposition in the proximal colon of mice

Abstract Cisplatin is an antimitotic drug able to cause acute and chronic gastrointestinal side effects. Acute side effects are attributable to mucositis while chronic ones are due to neuropathy. Cisplatin has also antibiotic properties inducing dysbiosis which enhances the inflammatory response, worsening local damage. Thus, a treatment aimed at protecting the microbiota could prevent or reduce the toxicity of chemotherapy. Furthermore, since a healthy microbiota enhances the effects of some chemotherapeutic drugs, prebiotics could also improve this drug effectiveness. We investigated whether chronic cisplatin administration determined morphological and functional alterations in mouse proximal colon and whether a diet enriched in prebiotics had protective effects. The results showed that cisplatin caused lack of weight gain, increase in kaolin intake, decrease in stool production and mucus secretion. Prebiotics prevented increases in kaolin intake, changes in stool production and mucus secretion, but had no effect on the lack of weight gain. Moreover, cisplatin determined a reduction in amplitude of spontaneous muscular contractions and of Connexin (Cx)43 expression in the interstitial cells of Cajal, changes that were partially prevented by prebiotics. In conclusion, the present study shows that daily administration of prebiotics, likely protecting the microbiota, prevents most of the colonic cisplatin‐induced alterations.
Multiple case study of processes used by hospitals to select performance indicators: do they align with best practices?

Abstract Several health policy institutes recommend reducing the number of indicators monitored by hospitals to better focus on indicators most relevant to local contexts. To determine which indicators are the most appropriate to eliminate, one must understand how indicator selection processes are undertaken. This study classifies hospital indicator selection processes and analyzes how they align with practices outlined in the 5-P Indicator Selection Process Framework. This qualitative, multiple case study examined indicator selection processes used by four large acute care hospitals in Ontario, Canada. Data were collected through 13 semistructured interviews and document analysis. A thematic analysis compared processes to the 5-P Indicator Selection Process Framework. Two types of hospital indicator selection processes were identified. Hospitals deployed most elements found within the 5-P Indicator Selection Process Framework including setting clear aims, having governance structures, considering indicators required by health agencies, and categorizing indicators into strategic themes. Framework elements largely absent included: adopting evidence-based selection criteria; incorporating finance and human resources indicators; considering if indicators measure structures, processes, or outcomes; and engaging a broader set of end users in the selection process. Hospitals have difficulty in balancing how to monitor government-mandated indicators with indicators more relevant to local operations. Hospitals often do not involve frontline managers in indicator selection processes. Not engaging frontline managers in selecting indicators may risk hospitals only choosing government-mandated indicators that are not reflective of frontline operations or valued by those managers accountable for improving unit-level performance.
Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma

Abstract Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communication in cancer, from development to metastasis. EV‐based liquid biopsy is a promising strategy for cancer diagnosis as EVs can be found in cancer patients’ body fluids. In this study, the lipid composition of breast cancer‐derived EVs was studied as well as the potential of blood plasma EVs for the identification of lipid biomarkers for breast cancer detection. Initially, an untargeted lipidomic analysis was carried out for a panel of cancerous and non‐cancerous mammary epithelial cells and their secreted EVs. We found that breast cancer‐derived EVs are enriched in sphingolipids and glycerophospholipids compared to their parental cells. The initial in vitro study showed that EVs and their parental cells can be correctly classified (100% accuracy) between cancerous and non‐cancerous, as well as into their respective breast cancer subtypes, based on their lipid composition. Subsequently, an untargeted lipidomic analysis was carried out for blood plasma EVs from women diagnosed with breast cancer (primary or progressive metastatic breast cancer) as well as healthy women. Correspondingly, when blood plasma EVs were analysed, breast cancer patients and healthy women were correctly classified with an overall accuracy of 93.1%, based on the EVs’ lipid composition. Similarly, the analysis of patients with primary breast cancer and healthy women showed an overall accuracy of 95% for their correct classification. Furthermore, primary and metastatic breast cancers were correctly classified with an overall accuracy of 89.5%. This reveals that the blood plasma EVs’ lipids may be a promising source of biomarkers for detection of breast cancer. Additionally, this study demonstrates the usefulness of untargeted lipidomics in the study of EV lipid composition and EV‐associated biomarker discovery studies. This is a proof‐of‐concept study and a starting point for further analysis on the identification of EV‐based biomarkers for breast cancer.
A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS

Polycystic ovary syndrome is a common reproductive endocrine condition that affects women of fertile age and is characterized by three main features, including hyperandrogenism, chronic anovulation, and polycystic ovaries. In addition, half of women with polycystic ovary syndrome have insulin resistance, and obesity or overweight, type 2 diabetes, hypertension, and hyperlipidemia are the most common metabolic abnormalities affecting (30%) women with polycystic ovary syndrome. Weight loss is regarded as the first-line treatment as it can potentially improve polycystic ovary syndrome parameters (androgen levels, menstrual cyclicity, lipid and glucose metabolism). However, achieving and maintaining weight loss can be challenging, and pharmacological agents could be essential to achieve optimal glycemic control and improve the endocrine disturbance associated with polycystic ovary syndrome. Glucagon-like peptide-1 receptor agonist has been demonstrated as monotherapy or in combination with metformin for managing obesity and insulin resistance associated with polycystic ovary syndrome. Yet, its effect on endocrine and metabolic parameters remains elusive, and further research is needed to close the gap. The aim is to evaluate the efficacy of glucagon-like peptide-1 receptor agonist monotherapy and/or a combined treatment between glucagon-like peptide-1 receptor agonist and metformin for improving anthropometric measurements, endocrine and metabolic parameters in lean and obese women with polycystic ovary syndrome. A systematic review of longitudinal cohort studies was conducted across databases including Ovid Medline, PubMed Central, and Cochrane Library between 2015 and 2022. Eligible studies included participants with polycystic ovary syndrome diagnosed according to the 2003 Rotterdam or the 1990 National Institutes of Health criteria. A total of eight studies including 486 patients with polycystic ovary syndrome were analyzed. The mean age was between 18 and 45 years with mean follow-up period between 12 and 32 weeks. In all these studies, results were comparable for the reduction in body mass index, waist circumference, fat mass, and visceral fat mass; however, it was more in combination therapy versus comparator. In conclusion, glucagon-like peptide-1 receptor agonists effectively reduce body weight and improve some of the endocrine and metabolic parameters of polycystic ovary syndrome. A combined treatment with glucagon-like peptide-1 receptor agonist and metformin had significant effects on weight loss and favorable results on endocrine and metabolic parameters, yet further research is needed to discover the long-term safety of combined therapy in women diagnosed with polycystic ovary syndrome and obesity or overweight.
Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection

ABSTRACT The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolomic analysis to characterize influenza-associated changes in the composition and metabolism of the mouse gut microbiota. We observed several taxonomic-level changes on day (D)7 post-infection, including a marked reduction in the abundance of members of the Lactobacillaceae and Bifidobacteriaceae families, and an increase in the abundance of Akkermansia muciniphila. On D14, perturbation persisted in some species. Functional scale analysis of metagenomic data revealed transient changes in several metabolic pathways, particularly those leading to the production of short-chain fatty acids (SCFAs), polyamines, and tryptophan metabolites. Quantitative targeted metabolomics analysis of the serum revealed changes in specific classes of gut microbiota metabolites, including SCFAs, trimethylamine, polyamines, and indole-containing tryptophan metabolites. A marked decrease in indole-3-propionic acid (IPA) blood level was observed on D7. Changes in microbiota-associated metabolites correlated with changes in taxon abundance and disease marker levels. In particular, IPA was positively correlated with some Lactobacillaceae and Bifidobacteriaceae species (Limosilactobacillus reuteri, Lactobacillus animalis) and negatively correlated with Bacteroidales bacterium M7, viral load, and inflammation markers. IPA supplementation in diseased animals reduced viral load and lowered local (lung) and systemic inflammation. Treatment of mice with antibiotics targeting IPA-producing bacteria before infection enhanced viral load and lung inflammation, an effect inhibited by IPA supplementation. The results of this integrated metagenomic-metabolomic analysis highlighted IPA as an important contributor to influenza outcomes and a potential biomarker of disease severity.
The origin and role of biological rock crusts in rocky desert weathering

Abstract. In drylands, microbes that colonize rock surfaces have been linked to erosion because water scarcity excludes traditional weathering mechanisms. We studied the origin and role of rock biofilms in geomorphic processes of hard lime and dolomitic rocks that feature comparable weathering morphologies, although these two rock types originate from arid and hyperarid environments, respectively. We hypothesized that weathering patterns are fashioned by salt erosion and mediated by the rock biofilms that originate from the adjacent soil and dust. We used a combination of microbial and geological techniques to characterize rock morphologies and the origin and diversity of their biofilms. Amplicon sequencing of the SSU rRNA gene suggested that bacterial diversity is low and dominated by Proteobacteria and Actinobacteria. These phyla only formed laminar biofilms on rock surfaces that were exposed to the atmosphere and burrowed up to 6 mm beneath the surface, protected by sedimentary deposits. Unexpectedly, the microbial composition of the biofilms differed between the two rock types and was also distinct from the communities identified in the adjacent soil and settled dust, showing a habitat-specific filtering effect. Moreover, the rock bacterial communities were shown to secrete extracellular polymeric substances (EPSs) that form an evaporation barrier, reducing water loss rates by 65 %–75 %. The reduced water transport rates through the rock also limit salt transport and its crystallization in surface pores, which is thought to be the main force for weathering. Concomitantly, the biofilm layer stabilizes the rock surface via coating and protects the weathered front. Our hypothesis contradicts common models, which typically consider biofilms to be agents that promote weathering. In contrast, we propose that the microbial colonization of mineral surfaces acts to mitigate geomorphic processes in hot, arid environments.
Assessing the operational cost of streamside management zones

A geographic information system (GIS) is a set of powerful, computer-based, analytical algorithms applied to solving spatial data problems. Recently, due to increases in memory, computing speed, and programming advances, personal computers have increased in use in solving spatial analysis problems. This study reports the benefits of applying a PC-based GIS to solve a common, but complicated, problem in forest management: assignment of harvesting areas with harvesting exclusion zones. Two stands each from the USDA Crossett Experimental Forest, and the University of Arkansas Forest, and four stands each from the Ouachita National Forest, and the Ozark National Forest (total 12) were analyzed to determine the changes in operational costs due to following best management practices by excluding sensitive areas from harvesting activity with streamside management zones (SMZs). In a one-time loss, land averaging 6.3 percent of the forest land was taken out of production due to the implementation of SMZs. Benefit/cost ratios of harvestable timber value to harvesting cost decreased with the imposition of SMZs, but the judicious use of portable bridging to span SMZs at critical locations mitigated losses considerably.