Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioinformatic Analysis Identifies Potential Key Genes in the Pathogenesis of Turner Syndrome

Background: Turner syndrome (TS) is a sex chromosome aneuploidy with a variable spectrum of symptoms including short stature, ovarian failure and skeletal abnormalities. The etiology of TS is complex, and the mechanisms driving its pathogenesis remain unclear. Methods: In our study, we used the online Gene Expression Omnibus (GEO) microarray expression profiling dataset GSE46687 to identify differentially expressed genes (DEGs) between monosomy X TS patients and normal female individuals. The relevant data on 26 subjects with TS (45,XO) and 10 subjects with the normal karyotype (46,XX) was investigated. Then, tissue-specific gene expression, functional enrichment, and protein-protein interaction (PPI) network analyses were performed, and the key modules were identified. Results: In total, 25 upregulated and 60 downregulated genes were identified in the differential expression analysis. The tissue-specific gene expression analysis of the DEGs revealed that the system with the most highly enriched tissue-specific gene expression was the hematologic/immune system, followed by the skin/skeletal muscle and neurologic systems. The PPI network analysis, construction of key modules and manual screening of tissue-specific gene expression resulted in the identification of the following five genes of interest: CD99, CSF2RA, MYL9, MYLPF, and IGFBP2. CD99 and CSF2RA are involved in the hematologic/immune system, MYL9 and MYLPF are related to the circulatory system, and IGFBP2 is related to skeletal abnormalities. In addition, several genes of interest with possible roles in the pathogenesis of TS were identified as being associated with the hematologic/immune system or metabolism. Conclusion: This discovery-driven analysis may be a useful method for elucidating novel mechanisms underlying TS. However, more experiments are needed to further explore the relationships between these genes and TS in the future.
Prevalence of Candida in Blood Cultures from in patients at a Teaching Hospital in Brazil

Candidemia is a serious public health problem and is associated with high morbidity and mortality rates. This study aimed to determine the prevalence of Candida species isolated from inpatients with candidemia at a teaching hospital in Brazil; characterize patients; correlate the risk factors and investigate the use of antibiotics. Medical records of 54 hospitalized patients from October 2013 to July 2015 were evaluated. The species identification was performed by automated system Vitek ® 2. In this period there were 19,962 hospitalizations, observing a frequency of 2.7 cases per 1,000 admissions. The prevalent species were Candida albicans (29.6%), C. tropicalis (29.6%), and C. parapsilosis (29.6%). Neonatal sepsis was the clinical condition more related to candidemia. The highest incidence of Candida species was observed in patients undergoing invasive procedures. All subjects studied were submitted to prolonged antibiotic therapy. The greatest diversity of Candida species was isolated from the Intensive Care Unit (ICU) and adult wards. The mortality rate found was 51.0%, of which 78.0% were ICU patients. These results reinforce the need to follow the clinical course of hospitalized patients for Candida infection through epidemiological surveillance in order to contribute to the action plan K e y w o r d s
The Influence of Different Types of Physical Activity on The Redox Status of Scuba Divers

Abstract The effect of scuba diving on ROS production and oxidative stress compared to that of other recreational activities is still poorly understood. The aim of this study was to assess the influence of different types of physical activity on the redox status of scuba divers by testing the pro- and anti-oxidative parameters immediately before and after different types of physical load. The prevalence study included 10 professional police divers. All examinees were male, 32 ± 5.1 years of age, well-trained, and with a minimum of five to a maximum of 20 years of diving experience. The study was divided into three experimental protocols: 1) an exercise test (at atmospheric pressure), 2) an at sea dive (30 meters for 30 minutes), and 3) a dive into river current (10 meters for 30 minutes). Immediately before and after the load test of the divers at atmospheric pressure and immediately before and after the dive, blood samples were taken to determine the values of the following pro-oxidant markers: O2−, H2O2, NO2− and TBARS, as well as antioxidant enzymes (SOD and CAT). A comparison of the results before and after physical activity for all three protocols revealed a significant increase in values for NO2−, O2−, H2O2 and CAT after physical activity. It can be concluded that the values of all oxidative stress markers depend on the season of the year in which the research is conducted or on the frequency of dives and degree of physical exertion during this period of the year.
The prospective study of clinico-etiological analysis on patients of papilloedema

Background: As the etiologies of papilloedema are important from prognostic point of view, early recognition of its cause & prompt treatment is required for better visual outcome. Objective: To study the etiology of the papilloedema in concerned patient and to study the optic disc changes by using ophthalmoscope and classify papilloedema. Materials and Methods: This prospective study was based on patients presenting to our tertiary care hospital. 45 cases were selected amongst the patients attending our hospital during the study duration from July 2012 to July 2014. 45 patients were registered and informed consent was taken prior to study, those patients not giving consent for study were excluded. These participants were interrogated their demographic, investigative and management data were recorded and documented on predesigned and pretested proforma, and analyzed by using SPSS version 17. Results: Papilloedema occur in a wide range of age group but are more common in the age group of 31-40 years. Overall, males were affected more than females. All the patients had bilateral papilloedema. The common etiological factor for papilloedema was intracranial space occupying lesion. According to stages of papilloedema, early papilloedema was most commonly seen. 57.2% of the patients had normal visual acuity (unaided) in papilloedema and all the patients had normal color vision pattern. Conclusion: A careful history, general and complete ophthalmological work-up with necessary investigations like CT, MRI/MRV are mandatory to diagnose patients with papilloedema.
Gambaran Faktor Resiko Kecacingan pada Anak Sekolah Dasar di Kota Banjarmasin

Helminthiasisis is an endemic and chronic diseases caused by parasitic worms that tendnot lethal but undermined the health of the human body. Helminthiasis is closely related topeople's behavior, especially personal hygiene and sanitation. The goal of this researchwere identify the risk factors of helminthiasis in primary school-student that can be usedas a basic information in determining the model of interventions and prevention forhelmint transmission and infestation effectively and efficiently in Banjarmasin. The studydesign was observational analytic studies conducted in period of April to December 2011in Banjarmasin. Data were obtained by interview questionnaire. The population was allelementary school students and their parents/guardians in Banjarmasin. Stools sampleswas taken from elementary school children and questionnaire sample was done by doinginterview to their parents /guardians. Based on stool examination there were 11(3%)positive samples identified (3%), which 7 (1,9%) was caused by T. trichiura, 1 (0,3%) wascaused by E. vermicularis, and 3 (0,8%) was caused by Hymenoepis sp. Questioneire dataof parents/guardians about helminthiasis showed that 56,3% parents classified as goodknowledge category, 66,6% in good attitude category and 56,3% in good behaviorcategory. Kecacingan merupakan penyakit endemik dan kronik yang diakibatkan oleh cacingparasit yang cenderung tidak mematikan namun menggerogoti kesehatan tubuhmanusia. Penyakit kecacingan erat kaitannya dengan perilaku masyarakat dalam halkebersihan perorangan dan sanitasi lingkungan. Penelitian ini bertujuan untukmengetahui faktor risiko kecacinganpada anak Sekolah Dasar (SD) yang dapatdigunakan sebagai dasar dalam menentukan model intervensi pencegahan penularandan penanggulangan kecacingan secara efektif dan efisien di Kota Banjarmasin.Penelitian menggunakan rancangan studi observasional analitik yang dilakukan padabulan April-Desember 2011 di Kota Banjarmasin. Data diperoleh dengan melakukanwawancara kuesioner. Populasi adalah semua anak SD dan orang tua/ wali anaksekolah dasar di kota Banjarmasin. Sampel untuk pengambilan feses adalah anak SDdan sampel untuk wawancara kuesioner adalah orang tua/ wali anak SD di kotaBanjarmasin. Pemeriksaan feses yang dilakukan pada anak SD didapat hasil positif 11(3%) sampel tinja, 7 orang (1,9%) disebabkan oleh Trichuris trichiura, 1 orang (0,3%)disebabkan oleh Enterobius vermicularis, dan 3 orang (0,8%) disebabkan olehHymenoepis sp. Pengetahuan orang tua/wali anak SD mengenai kecacingan dengankategori baik (56,3%), memiliki sikap pada kategori baik (66,6%) dan memilikiperilaku yang berada pada kategori baik (56,3%).
Documentation guidelines based on expectation of documentation helps accurate documentation among nurses in psychiatric settings

Careful documentation is an integral part of nursing care. It is written information about a client that describes the care or service provided by nurse to client according to their need. Through documentation, nurses communicate their observations, decisions, actions and outcomes of these actions for clients. In the present study an ‘ideal documentation guidelines of nurses caring mentally ill client ’was developed which can be used by the psychiatric nurses for thorough assessment as well as assessment of the documents. The ideal documentation guidelines consist of four important care areas namely are admission, discharge, selected procedure and specific incident. The study was conducted to compare the expectation of documentation by nurse administrators and actual performance by staff nurses in selected settings. Twenty five administrative nurses and 25 staff nurses were participated in the study. Result showed assessment of majority of actual performance documentation by the staff nurses showed almost proper behaviours and remaining was partially proper. No nurses documentations depict nurses behaviours improper (lowest level) or (highest level) i.e. proper. Same manner administrative nurse also expected a behaviour from the staff nurses that was almost proper behaviours in documentation. Study revealed actual performance with documentation and expectation of the administrators has a significant relationship. Training, CNE etc which might power to improve administrative nurses expectations of behaviours in psychiatric settings but an ideal documentation format or guideline can help nurses to follow proper documentation behaviour which will be based on the ideal documentation guidelines.
Earthquake Resistant Design-A comparative analysis of various bracing system with RC-frame

The current study specializes in the have a look at of the structural overall performance of metallic constructing with different bracing systems. The effectiveness of diverse varieties of bracing system has also been investigated. For this study at, a 10 storied frame structure has been analyzed and designed due to lateral loading. The structural performance of the RC frame building has been investigated the use of exclusive kinds of bracing system which includes X bracing, Inverted V-type bracing, K Bracing and single Diagonal bracing. A comparative analysis has been performed on lateral displacement, moments on beam between braced, story drift and un-braced structures at dissimilar floor stage. From the analysis it has been found that lateral displacement of bracing framed structure will be reduced as compare to RC-frame structure and also observed that X-Bracing system is more effective as compare to other bracing systems. X-Bracing frame structure is reduced by 35% displacement which is the largest one and as a consequence extensively contributes to extra structural stiffness. Finally, it can be stated that X-diagonally braced structure suggests higher structural overall performance amongst all the structures taken into consideration right here under comparable circumstances. Inclusion of bracing systems in the structure is more resilient in the event of the earthquake. At times it is also the cost effective solution for the earthquake resistant design of structures. Keywords— Lateral load, Bracing, X-Bracing, Stiffness, Displacement, Staad pro V8i. _____________________________________________________________________________________________________
A cross sectional study on association between overweight and obesity in adolescent population

Background: The rate of malnutrition in India remains high, increase in overweight and obesity have been observed in some areas undergoing rapid economic and epidemiologic transition. The aim was conducted to study association between obesity and overweight in adolescent population . Methods: A total of 1258 students (males-644; females-614) with an age group 10-19 years were selected from the higher secondary schools and junior colleges in the urban area of Tirupati. Results: The family history of obesity was reported by 54.7% of adolescents. The prevalence of overweight & obesity among males was found to be slightly higher in male adolescents 14.6% than in female adolescents 13.5%. Prevalence of overweight and obesity combined decreased with increase in the degree of physical activity from 12.7% in mild category to 10.0% in vigorous category and the differences are also found to be statistically significant in the present study. Conclusions: The present study recommended that the health education destined to inculcate healthy life style practices should be provided at an early age group to reduce the incidence of overweight and obesity in adolescent population.
The antinuclear antibodies fluorescent patterns in patients with connective tissue diseases

Material and Methods: The study included 50 patients with CTDs. They were recruited from Ibn-Sina Teaching Hospital in Mosul City for the period from January 2013 to April 2014. From each patient ten milliliters (ml) of blood were collected. Two milliliters were collected in tubes containing EDTA for performing complete blood count and ESR. In addition, relevant laboratory tests including liver function test, renal function tests, and urinalysis were also conducted. The remaining of the separated serum was kept in clean tubes and stored at -20 C until use for IIF tests. The tested autoantibodies by IIF technique included ANA and anti-dsDNA autoantibodies.
INTER-RELATIONSHIP OF POLYCYSTIC OVARIAN SYNDROME WITH BMI AND DIABETES

Article History: Received 2, April, 2015 Received in revised form 10, April, 2015 Accepted 4, May, 2015 Published online 28, May, 2015 In recent years Polycystic Ovarian Syndrome (PCOS) is globally emerging disorder among women. The present study undertaken in Mumbai city was to create awareness about PCOS. The target age group was 10 – 40 years and above. The study also focussed on interrelationship between BMI and diabetes as associated factors with PCOS. We observed that 23.87% of PCOS positive subjects were overweight. From our study a possible correlation could be derived that PCOS is a hereditary syndrome. Hirsutism, acne, alopecia, obesity and irregular periods were reported as associated symptoms. About 23.87% PCOS positive subjects were suffering with diabetes. Level of awareness about PCOS was very poor in PCOS negative subjects. Hence, initiative needs to be taken for women to be provided with information about PCOS and encourage timely diagnosis.
IMMUNOTOXICITY OF HEROIN AND CANNABIS IN A SAMPLE OF EGYPTIAN POPULATION

Addiction is one of the world’s major health problems with large direct health costs (psychiatric and physical) as well as massive indirect costs to the society. The present study aimed to investigate the toxic effect of heroin and cannabis addiction on immune system and the role of reactive oxygen species (ROS) in immunotoxicity. 84 individuals; whose ages ranged from 18 to 38 years were classified into 6 groups: Group I, male subjects addicted to heroin; group II, male subjects addicted to Cannabis; group III female subjects addicted to heroin; group IV, female subjects addicted to Cannabis; group V, control male subjects; group VI, control female subjects. The control groups comprised 24 persons; while the study group included 60 addicts. 10 mL urine samples were screened for detection of substance abuse. Four mL blood was collected from each subject after taking informed consent and was divided as follows: Two mL for detection of cytokines; interlukin 2 & 6 (IL2 & IL6) by using flow cytometry and the other two mL for studying ROS (reduced glutathione; thiobarbituric acid reactive substances {TBARS} and protein oxidation) by using colorimetric assay. The results revealed a significant decrease in serum IL-2 in both heroin and cannabis males & females addicts compared to control group (64.9 + 2.999 & 62.93 + 2.198 respectively) and (64.45 + 1.703 & 61.67 + 2.182 respectively). While there is no significant difference in the IL-6 level. Regarding ROS; there is significant decrease in protein thiols level in both heroin and cannabis males & females addicts compared to control group (418.8+13.10 & 406.8+14.99 respectively) and (412.9 + 14.35 & 408.8 + 14.67 respectively). While, there are significant increases in both TBARS and protein oxidation in both cannabis and heroin males and females addicts in comparison to the control group. It could be concluded that heroin and cannabis addiction might play a role in the immunotoxicity through effects on the ROS.
Determination of Quality of Marine Fishes Based on Total Volatile Base Nitrogen test ( TVB-N )

This study was carried out to evaluate the quality of five marine fishes yellowfin tuna (Thunnus albacores, Bonnaterre, 1788), sailfish (Istiophorus platypterus, Shaw, 1792), slaya/sardine (Sardinella gibbosa, Bleeker, 1849), squid (Loligo duvaucelii, D' Orbigny, 1835) and shrimp (Fenneropenaeus indicus, H. Milne Edwards, 1837) based on total volatile base nitrogen test (TVB-N). The studied fish was collected from 19 commercial retail outlets in Sri Lanka in 2012, kept under ice and immediately transferred to laboratory for further analysis. The total volatile basic nitrogen (TVB-N) test was performed to assess the quality status of fresh fish. The limits of TVB-N for fishery products in Commission Regulation (EC) NO 2074/2005, which was ranged between 25 to 35 milligrams of nitrogen/ 100grams of fish flesh. The results of the present study revealed that base the total volatile base nitrogen (TVB-N) content, 5% of yellowfin tuna, 8% of sailfish, 12% of sardine, 100% of squids and 42% shrimp were not fit for the human consumption. [B.K.K. K. Jinadasa. Determination of Quality of Marine Fishes Based on Total Volatile Base Nitrogen test (TVB-N). Nat Sci 2014;12(5):106-111]. (ISSN: 1545-0740). http://www.sciencepub. net/nature. 14
EDUCATION TO HEALTHY LIFE STYLE WITH THE ACCENT TO SLEEP HABITS – INTERVENTION PROGRAMS

Annotation Our research group has went on several intervention programs which were applied to infants, elementary school and junior high school students and university sports-club students and also People who suffered disaster of Hanshin-Awaji Great Earthquake in 1995. All intervention programs were performed and are now going on to promote mental and physical health. The current intervention program focuses on the intervention which is based on a newly constructed series-of-leaflets for promoting sleep health entitled “Three great benefits due to ‘Go to Bed Early, Get up Early and Do not Forget Breakfast! ”. These leaflets consists of four versions for parents of small children, athletes, women and people who suffered great disasters. In this keynote lecture, we would like to focus on the results of three intervention studies to promote the athletes who are the members of succor team of Kochi University held in November of 2008 (Takeuchi et al., 2012), 2010 (Wada et al., submitted) and 2011 (Wada et al., unpublished; Harada et al.,. unpublished). All the three kinds of intervention seem to be effective for athletes to change their chronotype into morning-typed one, promote the sleep and mental health and finally improve their performance in playing sports.
Motion of MHD Micropolar Fluid Toward a Stagnation Point Under the Influence of Induced Magnetic Field

A steady two-dimensional Magnetohydrodynamic (MHD) mixed convection stagnation point motion of an incompressible, viscous and electrically conducting micropolar fluid toward a stretching and or shrinking vertical surface with surface heat flux is investigated. The effects of induced magnetic field and the heat flux radiation are considered. The transformed differential equations are solved numerically by a finite-differencemethod. The results for skin friction, heat transfer and induced magnetic field coefficients are obtained. The velocity, micro-rotation and temperature distribution for various parameters are shown. The results are in good agreement with earlier studies. The present results are compared with existing results in the literature and shown to be in good conformity as shown in the resulting table and curves.
Reperfusion Therapy in Wake-Up Stroke: A Retrospective Observational Study

Abbreviations: ASPECTS: Alberta Stroke Program Early CT Score; CT: Computed Tomography; EIC: Early Ischemic Changes; FKA: First Known Abnormal; IQR: Interquartile Range; IV: Intravenous; LKN: Last Known Normal; mRS: modified Rankin Scale; MRI: Magnetic Resonance Imaging; rtPA: recombinant Tissue plasminogen Activator; SD: Standard Deviation; SICH: Symptomatic Intracerebral Haemorrhage; SITS-MOST: Safe Implementation of Thrombolysis in Stroke Monitoring Study; WUS: Wake-Up Stroke
No association between ITGAV rs3738919 and rs3768777 polymorphisms and rheumatoid arthritis susceptibility in Iranian population

Abstract Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by angiogenesis, cell proliferation and bone and cartilage damage in the affected joint. Many genetic and environmental factors contribute to RA susceptibility. ITGAV is a member of the integrin family, which plays a major role in bone destruction, angiogenesis and macrophage-dependent inflammation and has been suggested that it may be an RA susceptibility gene. In this study, we investigated association of two single nucleotide polymorphisms in ITGAV (rs3738919 and rs3768777) with susceptibility to RA. Methods: Iranian patients with confirmed RA, aged over 50 years, were compared with healthy controls for allelic and genotypic frequencies of these polymorphisms. The subjects and controls were matched through their race, age and sex. After whole genome extraction, we compared genotype frequencies of analyzed alleles in RA patients and controls using a polymerase chain reaction (PCR)-restriction fragment length polymorphism assay. Association of rs3738919 and rs3768777 with RA was tested in these two sample sets using the χ2-test. Results: Statistical analysis indicated no association between RA and rs3738919 allele frequencies (C and A alleles), single genotype frequencies (AA, AC, CC) and combined genotype frequencies of (AC+CC vs. AA). We also found no evidence of association between rs3768777 SNP allele frequencies, single genotype frequencies and combined genotype frequencies and RA susceptibility. Conclusions: This study did not find any association between RA and ITGAV rs3738919 and rs3768777 polymorphisms in Iranian patients. However, this finding is not conclusive due to the limited sample size. A subsequent study with a larger sample size is recommended.