Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamics of upwelling in the Alaskan Beaufort Sea and associated shelfamp#x02013;basin fluxes

Data from a high-resolution mooring array deployed across the Alaskan Beaufort shelfbreak and slope, together with an idealized numerical model, are used to investigate the dynamics of wind-driven upwelling and the magnitude of the resulting shelf–basin exchange. The analysis focuses on a single storm event in November 2002 when the sea-ice concentration was 50–70%. The normally eastwardflowing shelfbreak jet was reversed to the west, and the secondary circulation near the shelfbreak was characterized by offshore flow in the upper layer and a nearly equal amount of onshore flow at depth. Ekman theory accurately predicts the strength of the secondary circulation when one takes into account the ice–ocean stress. The depth-integrated alongstream momentum balance reveals that, near the shelf edge, the reversed jet is driven by a combination of the surface stress and divergence of crossstream momentum flux. The reversed jet is primarily spun-down – before the winds subside – by the alongstream pressure gradient that likely results from the variation in sea surface height. The shelf– basin fluxes of heat, freshwater, and nitrate resulting from the storm are substantial. Much of the yearly supply of heat to the Beaufort shelf from the inflowing Pacific water through Bering Strait was fluxed offshore, and the amount of freshwater transported into the basin represents a substantial fraction of the year-to-year variation in the freshwater inventory of the Beaufort Gyre. The on-shelf flux of nitrate from 4 to 5 such storms could account for most of the net annual primary production that occurs on the Beaufort shelf. & 2013 Elsevier Ltd. All rights reserved.
Upregulation of STC2 in colorectal cancer and its clinicopathological significance

Background Stanniocalcin 2 (STC2) is a glycoprotein hormone involved in many biological processes and a secretory protein that regulates malignant tumor progression. The aim of the present study was to further explore the clinicopathological significance and prognostic role of STC2 in colorectal cancer (CRC). Methods In this study, STC2 expression was first investigated in Gene Expression Omnibus and The Cancer Genome Atlas, and then validated with the data from our medical center. Univariate and multivariate analyses were performed to assess the association between prognostic factors and survival outcome. Results In Gene Expression Omnibus and The Cancer Genome Atlas databases, bioinformatics analysis confirmed that STC2 was significantly increased in CRC compared with that in normal tissues (P<0.01), and CRC patients with high STC2 expression had a shorter overall survival. By analyzing data from our medical center, the results also showed that STC2 expression of CRC tissues was higher than that in normal tissues, whether the transcriptional or protein levels. In the CRC tissues, high STC2 expression was significantly correlated with lymph node metastasis (P=0.047), distant metastasis (P=0.040), and advanced clinical stage (P=0.047). Moreover, Kaplan–Meier analyses indicated that high STC2 expression predicted a worse prognosis, and multivariate Cox regression analysis revealed that STC2 was an independent prognostic factor for overall survival (HR =1.976, 95% CI: 1.092–3.576, P=0.024) in patients with CRC. Conclusion Our results suggested that STC2 played an important role in CRC progression and prognosis, and could be a useful biomarker for survival prediction.
Optimizing sequential treatment with anti-EGFR and VEGF mAb in metastatic colorectal cancer: current results and controversies

Anti-EGFR mAb (cetuximab or panitumumab) and anti-VEGF mAb (bevacizumab) are the two main targeted agents available for RAS wild-type (WT) metastatic colorectal cancer (mCRC) treatment. Nonetheless, three head-to-head clinical trials evaluating anti-EGFR mAb vs -VEGF mAb in first-line treatment failed to conclude a uniform result. Recently, a few small clinical studies revealed that prior use of bevacizumab may impair the effect of cetuximab or panitumumab. Preclinical studies have also suggested that pretreatment with bevacizumab may lead to simultaneous resistance to anti-EGFR mAb. Therefore, we performed this review to summarize the available data regarding the optimal sequential treatment of anti-EGFR and -VEGF mAb for RAS or KRAS WT mCRC and discuss the potential mechanisms that may explain this phenomenon. Primary tumor location and early tumor shrinkage have emerged as new potential prognostic and predictive factors in mCRC. We also collected information to explore whether these factors affect the optimal sequencing of targeted therapy in mCRC. However, definite conclusions cannot be made, and we can only speculate on optimal treatment recommendations based on the contradictory results.
Combined Treatment with Doxorubicin and Rapamycin Is Effective against In Vitro and In Vivo Models of Human Glioblastoma

Despite numerous clinical trials, glioblastoma (GBM) remains a tumor that is difficult to treat. The aim of this study was to investigate the potential of a new pharmacological approach, combining doxorubicin (Dox) and rapamycin (Rapa), in in vitro and in vivo GBM models. Cytotoxic and anti-proliferative effects of Rapa plus Dox treatments were analyzed in GBM cell lines. The in vivo effectiveness of these treatments was investigated in an orthotopic xenograft mice model of GBM. In vitro results demonstrated that prolonged exposure to Rapa sensitize GBM cells to Dox treatments. In vivo results demonstrated that Rapa (5 mg/kg) plus Dox (5 mg/kg) determined the major tumor growth inhibition (−97.29% vs. control) but results in greater toxicity. The combination Rapa plus Dox (2.5 mg/kg) showed a tumor inhibition like Rapa plus Dox (5 mg/kg) with a toxicity comparable to Rapa alone. Thus, this study demonstrated the efficacy of this pharmacological approach, providing the rationale for a clinical application of this combinational therapy in “poor-responder” GBM patients.
Nigella sativa (Black Seed) Active Constituents and Therapeutic Applications

Nigella sativa (N. sativa) is a plant native to, and cultivated in, North Africa, Turkey, and the Middle East has been used throughout the world medicinally and as a food seasoning for centuries. It is widely used in various traditional systems of medicine such as Ayurveda, Unani, and Siddha. The seeds of N. sativa are employed as a therapeutic tool for many different ailments and conditions. N. sativa has been shown to have antihypertensive, antimicrobial, immunomodulatory, diuretic, digestive, analgesic, antimicrobial, hypoglycemic, antioxidant, anti-inflammatory, anticancer, and antihistaminic properties, among others. Extensive preclinical, animal, and clinical research has been conducted on N. sativa’s properties. Due to its multitude of potential applications, N. sativa is among the top-ranked, evidence-based herbal medicines. Research has also revealed that most of the therapeutic properties of this plant are attributed to its essential oil constituent, thymoquinone. This paper endeavors to provide a detailed report on the characteristics, historical and modern uses, chemical composition, benefits of standardization, pharmacological activities, safety, toxicology, and recommended dosages of Nigella sativa.
Search for lepton-ﬂavour-violating decays of Higgs-like bosons

A search is presented for a Higgs-like boson with mass in the range 45 to 195 GeV / c 2 decaying into a muon and a tau lepton. The dataset consists of proton-proton inter-actions at a centre-of-mass energy of 8 TeV, collected by the LHCb experiment, corresponding to an integrated luminosity of 2 fb − 1 . The tau leptons are reconstructed in both leptonic and hadronic decay channels. An upper limit on the productioncross-sectionmultipliedbythebranchingfraction at 95% conﬁdence level is set and ranges from 22 pb for a boson mass of 45 GeV / c 2 to 4 pb for a mass of 195 GeV / c 2 .
Effects of Cervical Rotatory Manipulation (CRM) on Carotid Atherosclerosis Plaque in Vulnerability: A Histological and Immunohistochemical Study Using Animal Model

Background The safety of cervical rotatory manipulation (CRM) is still controversial, especially in patients with carotid artery atherosclerosis (CAS). The study aimed to investigate the effects of CRM on carotid plaques in vulnerability. Methods 50 rabbits were randomly divided into four groups: model rabbits with CRM [CAS-CRM (n=15)]; model rabbits without CRM [CAS (n=15)]; normal rabbits with CRM [Normal-CRM (n=10)]; and Blank-control group (n=10). CAS disease models were induced by carotid artery balloon injury combined with a high-fat diet for 12 weeks. Then, CRM technique was performed in CAS-CRM and Normal-CRM groups for 3 weeks. In the end, determination of serum level of hs-CRP and Lp-PLA2, histological analysis under HE and Masson trichromic staining, and immunohistochemical analysis with CD34 and CD68 antibody were completed in order. Results Carotid stenosis rates on successful model rabbits ranged from 70% to 98%. The CAS-CRM group had an increased level of hs-CRP (P<0.05), in comparison with the CAS group, whereas effects were not significant between the Normal-CRM group and Blank-control group. In comparison with the CAS group, the positive expression of CD34 and CD68 in the CAS-CRM group increased significantly (P<0.05). Conclusion CRM therapy may increase the vulnerability of carotid plaque in rabbits with severe CAS.
24-hour accelerometry in COPD: Exploring physical activity, sedentary behavior, sleep and clinical characteristics

Background The constructs and interdependency of physical behaviors are not well described and the complexity of physical activity (PA) data analysis remains unexplored in COPD. This study examined the interrelationships of 24-hour physical behaviors and investigated their associations with participant characteristics for individuals with mild–moderate airflow obstruction and healthy control subjects. Patients and methods Vigorous PA (VPA), moderate-to-vigorous PA (MVPA), light PA (LPA), stationary time (ST), average movement intensity (vector magnitude counts per minute), and sleep duration for 109 individuals with COPD and 135 healthy controls were obtained by wrist-worn accelerometry. Principal components analysis (PCA) examined interrelationships of physical behaviors to identify distinct behavioral constructs. Using the PCA component loadings, linear regressions examined associations with participant (+, positive correlation; -, negative correlation), and were compared between COPD and healthy control groups. Results For both groups PCA revealed ST, LPA, and average movement intensity as distinct behavioral constructs to MVPA and VPA, labeled “low-intensity movement” and “high-intensity movement,” respectively. Sleep was also found to be its own distinct behavioral construct. Results from linear regressions supported the identification of distinct behavioral constructs from PCA. In COPD, low-intensity movement was associated with limitations with mobility (−), daily activities (−), health status (+), and body mass index (BMI) (−) independent of high-intensity movement and sleep. High-intensity movement was associated with age (−) and self-care limitations (−) independent of low-intensity movement and sleep. Sleep was associated with gender (0= female, 1= male; [−]), lung function (−), and percentage body fat (+) independent of low-intensity and high-intensity movement. Conclusion Distinct behavioral constructs comprising the 24-hour day were identified as “low-intensity movement,” “high-intensity movement,” and “sleep” with each construct independently associated with different participant characteristics. Future research should determine whether modifying these behaviors improves health outcomes in COPD.
Individual-Level SNP Diversity and Similarity Profiles

Classic concepts of genetic (gene) diversity (heterozygosity) such as Nei (1973: PNAS) and Nei and Li (1979: PNAS) nucleotide diversity were defined within the context of populations. Although variations are often measured in population context, the basic carriers of variation are individuals. Hence, measuring variations such as SNP of individual against a reference genome, which has been ignored currently, is certainly of its own right. Indeed, similar practice has been a tradition in ecology, where the basic framework of diversity measure is individual community sample. We propose to use Renyi-entropy-derived Hill numbers to define SNP (single nucleotide polymorphism) diversity (including alpha-, beta-, and gamma-diversities) and similarity profiles. Hill numbers are derived from Renyi entropy, of which Shannon entropy is a special case and which have found widely applications including measuring the quantum information entanglement, wealth distribution in economics and ecological diversity. The newly proposed SNP diversity not only complements the existing genetic diversity concepts by offering individual-level metrics, but also offers building blocks for comparative genetic analysis at higher levels. The profile concept also helps to resolve a dilemma in measuring diversity: the choice from various diversity indexes, because diversity profile unifies some of the most commonly used indexes (as special cases) with different diversity orders (along the rareness-commonness spectrum of gene mutations). Finally, the profiles can be estimated with rarefaction approach, which may help to relieve some effect of insufficient sequencing coverage.
Open-Set Recognition Using Intra-Class Splitting

This paper proposes a method to use deep neural networks as end-to-end open-set classifiers. It is based on intraclass data splitting. In open-set recognition, only samples from a limited number of known classes are available for training. During inference, an open-set classifier must reject samples from unknown classes while correctly classifying samples from known classes. The proposed method splits given data into typical and atypical normal subsets by using a closed-set classifier. This enables to model the abnormal classes by atypical normal samples. Accordingly, the open-set recognition problem is reformulated into a traditional classification problem. In addition, a closed-set regularization is proposed to guarantee a high closed-set classification performance. Intensive experiments on five well-known image datasets showed the effectiveness of the proposed method which outperformed the baselines and achieved a distinct improvement over the state-of-the-art methods.
Sosial Criticism of Minangkabau Cultural in The Persiden Novel by Wisran Hadi

Wisran Hadi in the novel Persiden revealed the social problems that occur in the Minangkabau community. The purpose of writing this article is to describe the type of problems or social criticism in the novel Persiden Wisran Hadi. These results indicate that the novel form of social criticism Persiden Hadi Wisra work covering issues of culture, customs, religion, law, and politics. These social problems are conveyed in a direct and indirect form. Clearly, this criticism is a critique of (1) the problem of government bureaucracy that is not functioning as it should; (2) a Mamak who does not understand the condition of a nephew and Sumando who likes to interfere in matters that exist within the wife; (3) the rapidly growing number of political parties; (4) community morals that deviate from religious norms, the function of surau, and changes in beliefs; and (5) traffic rules, demonstrations, and building placement guidelines do not comply with the law.
Long-term cost-effectiveness of the fixed-dose combination of tiotropium plus olodaterol based on the DYNAGITO trial results

Purpose Combinations of long-acting bronchodilators are recommended to reduce the rate of COPD exacerbations. Evidence from the DYNAGITO trial showed that the fixed-dose combination of tiotropium + olodaterol reduced the annual rate of total exacerbations (P<0.05) compared with tiotropium monotherapy. This study aimed to estimate the cost-effectiveness of the fixed-dose combination of tiotropium + olodaterol vs tiotropium monotherapy in COPD patients in the French setting. Patients and methods A recently developed COPD patient-level simulation model was used to simulate the lifetime effects and costs for 15,000 patients receiving either tiotropium + olodaterol or tiotropium monotherapy by applying the reduction in annual exacerbation rate as observed in the DYNAGITO trial. The model was adapted to the French setting by including French unit costs for treatment medication, COPD maintenance treatment, COPD exacerbations (moderate or severe), and pneumonia. The main outcomes were the annual (severe) exacerbation rate, the number of quality-adjusted life-years (QALYs), and total lifetime costs. Results The number of QALYs for treatment with tiotropium + olodaterol was 0.042 higher compared with tiotropium monotherapy. Using a societal perspective, tiotropium + olodaterol resulted in a cost increase of +€123 and an incremental cost-effectiveness ratio (ICER) of €2,900 per QALY compared with tiotropium monotherapy. From a French National Sickness Fund perspective, total lifetime costs were reduced by €272 with tiotropium + olodaterol, resulting in tiotropium + olodaterol being the dominant treatment option, that is, more effects with less costs. Sensitivity analyses showed that reducing the cost of exacerbations by 34% increased the ICER to €15,400, which could still be considered cost-effective in the French setting. Conclusion Treatment with tiotropium + olodaterol resulted in a gain in QALYs and savings in costs compared with tiotropium monotherapy using a National Sickness Fund perspective in France. From the societal perspective, tiotropium + olodaterol was found to be cost-effective with a low cost per QALY.
Diet Quality of Farm and Nonfarm Households in the First Half of the Twentieth Century: The Roles of Technological Change and Women’s Work

ABSTRACT In recent decades, dramatic increases in Americans’ obesity rates have led some nutrition activists to call for a return to the dietary norms of earlier times when homemakers spent more time in meal preparation. Using archival data from unique survey records gathered in Upstate New York in 1936 and 1952, we provide descriptive information on the quality of the diets using measures of the variety of foods served and a modified version of U.S. Department of Agriculture’s Healthy Eating Index. Our multivariate analyses focus in on the relationships between diet quality and sociodemographics, homemakers’ time use, and household technology. We conclude that the typical Upstate New York diet of the 1930s was not of high quality, but improvements had occurred by the early 1950s. Our multivariate analyses reveal that access to modern kitchen technology had a strong, positive association with diet quality while homemakers’ time devoted to food-related activities was only weakly linked.
Patient reported outcomes in elective laparoscopic cholecystectomy

Backgrounds/Aims Traditional outcome measures (e.g., length of hospital stay, morbidity, and mortality) are used to determine the quality of care, but these may not be most important to patients. It is unclear which outcomes matter to patients undergoing elective laparoscopic cholecystectomy (ELC). We aim to identify patient-reported outcome measures (PROM) which patients undergoing ELC valued most. Methods A 45-item questionnaire with Four-point Likert-type questions developed from prior literature review, prospectively administered to patients treated with ELC at a tertiary institution in Singapore. Results Seventy-five patients participated. Most essential factors were technical skill and experience level of a surgeon, long-term quality of life (QoL), patient involvement in decision-making, communication skill of a surgeon, cleanliness of the ward environment, and standards of nursing care. Least important factors were hospitalization leave duration, length of hospital stay, a family's opinion of the hospital, and scar cosmesis. Employed patients were more likely to find hospitalization leave duration (p<0.001) and procedure duration (p=0.042) important. Younger patients (p=0.048) and female gender (p=0.003) were more likely to perceive scar cosmesis as important. Conclusions Patients undergoing ELC value long-term QoL, surgeon technical skill and experience level, patient involvement in decision-making, surgeon communication skill, cleanliness of the ward environment, and nursing care standards. Day-case surgery, medical leave, family opinion of hospital, and scar cosmesis were least important. Understanding what patients value will help guide patient-centric healthcare delivery.
Grey matter myelination

There is now increasing evidence that myelin is not only generated early in development, but also during adulthood possibly contributing to lifelong plasticity of the brain. In particular, human cortical areas responsible for the highest cognitive functions seem to require decades until they have reached their maximal amount of myelination. Currently, we know very little about the mechanisms and the functions of grey matter myelination. In this emerging field key questions await to be addressed: How long does myelination last in humans? How is grey matter myelination regulated? What is the function of myelin in the grey matter? Does grey matter myelination limit and/or promote neuronal plasticity? Finding answers to these questions will be important for our understanding of normal, but also abnormal cortex function in a number of neurological and psychiatric diseases.
Effect of the flavonoid baicalin on the proliferative capacity of bovine mammary cells and their ability to regulate oxidative stress

Background High-yielding dairy cows are prone to oxidative stress due to the high metabolic needs of homeostasis and milk production. Oxidative stress and inflammation are tightly linked; therefore, anti-inflammatory and/or natural antioxidant compounds may help improve mammary cell health. Baicalin, one of the major flavonoids in Scutellaria baicalensis, has natural antioxidant and anti-inflammatory properties in various cell types, but its effects on bovine mammary epithelial cells (BMECs) have not been investigated. Methods Explants from bovine mammary glands were collected by biopsy at the peak of lactation (approximately 60 days after the start of lactation) (n = three animals) to isolate BMECs corresponding to mature secretory cells. Cell viability, apoptosis, proliferative capacity and reactive oxygen species (ROS) production by BMECs were measured after increasing doses of baicalin were added to the culture media in the absence or presence of H2O2, which was used as an in vitro model of oxidative stress. Results Low doses of baicalin (1–10 µg/mL) had no or only slightly positive effects on the proliferation and viability of BMECs, whereas higher doses (100 or 200 µg/mL) markedly decreased BMEC proliferation. Baicalin decreased apoptosis rate at low concentrations (10 µg/mL) but increased apoptosis at higher doses. ROS production was decreased in BMECs treated with increasing doses of baicalin compared with untreated cells, and this decreased production was associated with increased intracellular concentrations of catalase and NRF-2. Irrespective of the dose, baicalin pretreatment attenuated H2O2-induced ROS production. Discussion These results indicate that baicalin exerts protective antioxidant effects on bovine mammary cells. This finding suggests that baicalin could be used to prevent oxidative metabolic disorders in dairy cows.