Miracle-dz/UniFAR-FTUs huggingface dataset:
Características fisicoquímicas de nueve híbridos de sorgo (Sorghum bicolor L. Moench) y su relación con el contenido de almidón y digestión ruminal

Nine grain sorghum hybrids (bicolor Sorghum L. Moench) were analyzed to evaluate the relationship between thephysical [dry matter (DM), thousand grains weigh (TGW), particle size (PS), relative density (RD), area surface (AS)and particles for gram (PG), hard endosperm (HE) and soft endosperm (SE)]; and chemical characteristics [totalnitrogen (N), acid detergent fiber (ADF), neutral detergent fiber (NDF), total starch (S), soluble starch (S-S), insolublestarch (I-S)]. The predicted ruminal starch digestion (PRSD) was determined enzymatically from the S-S and I-Sfractions. The average of TGW, PS, RD, AS, PG and HE were 24.61 g, 3.17 mm, 1.30 g/cm3, 17.44 cm2/g, 30.33 and46.68 % respectively. The average (%) of DM, CP, FDN, FDA, S, S-S and I-S were 92.47, 8.19, 19.17, 8.30 69.58, 6.00and 47.74 respectively. The concentration of tannins was very low ( 0.05) among the physical or chemical variables withthe total content of starch in the grain; however, the variables relative density and area surface, significantly increasesprediction (PRSD,% = 74.058 - 0.108HE + 0.027AS – 5.887RD, R2= 0.77, P<0.05). According to the study, the sorghumhybrids are of intermediate hardness, free of tannins and with a potential of ruminal starch digestion of 66 %
Prevalence and Treatment of Ketosis in Dairy Cows in and Around Addis Ababa, Ethiopia

Prevalence of ketosis in dairy cows at Genesis farm, Slam farm, Akaki kality farm and Bollie private farm located in and around Addis Ababa, Ethiopia was studied from November 2008 to March 2009. The ketone bodies in urine and milk samples were semi quantified by Rothera's test and Strip test was used specifically for urine sample. The body temperature, pulse rate, respiratory rate, rumen motility, abnormalities in urine, faeces and milk was recorded. The affected cows were treated with dextrose 50%, or dextrose 25% plus dexamethasone or propylene glycol and dexamethasone. The ketosis prevalence rate was maximum in the month of January (30.77%), in higher age (8-9 years) groups (13.4%), during 1 st month of lactation (18.87%) and 4 th lactation number (18.8%). The decrease in milk yield from ketosis affected cow ranged from 18.18 to 40%. The cows were administered with dextrose 50% or dextrose 25% plus dexamethasone or propylene glycol and dexamethasone and effective restoration of milk-yield within 3-4 days were recorded. To prevent this metabolic disease, immediate diagnosis and proper treatment of affected cow is essential to restore the milk yield. In addition, veterinary professionals need to give great attention for diagnosis, management and control of this disease during risk stage.
Prevalence of prehypertension in young adults in a semi-urban district in Telangana

Background: Referred to as silent killer, is one of the leading causes of cardiovascular diseases. The risk of cardiovascular disease in people with prehypertension increases with the increase in burden of the other risk factors such as obesity, diabetes mellitus and dyslipidaemia. This study was undertaken to estimate the prevalence of prehypertension among the young adults in our area. Methods: 2658 patients, between 18-35 years of age, were included in the study. Complete physical and clinical examination, blood pressure, blood tests for cholesterol levels, blood glucose levels, and triglyceride levels were done. BMI, waist to hip ratio was also calculated. Results: 1433 (53.9%) of the patients were females and 1225 (46.1%) were males. Pre hypertension was found in 846 (31.8%) hypertension in 261(9.8%) young adults. There was a higher rate of BMI, blood glucose levels and cholesterol in these patients. Conclusions: There is a high prevalence of prehypertension among the young adults in our geographical. Therefore, awareness among the community, lifestyle modifications such as proper nutrition and less of fatty foods, regular check-ups especially for those with risk factors and timely treatment are very essential for curbing outcomes such as cardiovascular diseases.
Acción gen asociado con la expresión de heterosis en Jiló (Solanum gilo Raddi.)

The objectives of this work were to assess heterosis and its components in F 1 hybrids of a diallel cross among lines of scarlet eggplants (Solanum gilo Raddi, syn. S. aeth opicum L.), and to study the modes of gene action associated with its expression. Six lines (Morro Redondo, Branco Comprido, BGH-1544, Tingua, Iraja, Comprido Verde Claro) and 15 hybrids resulting from a diallel cross among them (reciprocals excluded) were tested in a randomized complete block design with four replications. Traits under study were total yield, mean fruit mass and fruit length/diameter ratio. There was no evidence of epistatic gene action in the expression of any of the traits under study. Heterosis for yield could be explained by overdominance, but higher yields were only weakly associated with larger frequencies of dominant alleles an indication that yields may be markedly influenced by the action of relatively few loci with overdominant gene action. Heterosis for mean fruit mass was associated with incompletely dominant gene action, and larger fruit mass was associated with larger proportions of dominant alleles. For fruit length/diameter ration (L.D -1 ), heterosis was due to incompletely dominant gene action, and dominant alleles were predominantly associated with lower L.D -1 values.
Efficacy and tolerability of aceclofenac versus diclofenac in the treatment of knee osteoarthritis : A multicentre study.

A six month prospective, controlled, randomised, parallel and double-blind clinical trial was designed to assess the efficacy and tolerability of aceclofenac (AC) in comparison to diclofenac (DC) in the treatment of knee osteoarthritis (OA). Three hundred and thirty-five patients (aged from 32 to 80 years) who fulfilled the EULAR clinical and radiological criteria for OA of the knee were included in the study. Patients were randomly allocated to 2 groups receiving 100 mg AC bid (170 patients) or 50 mg DC tid (165 patients), for 6 months. The main outcome variables were the Lequesne OA severity index (OSI) and pain on a visual analogue scale (VAS). Secondary measures were knee flexion and extension and evaluation of knee function. All parameters were evaluated at baseline, after 15 days and monthly throughout the study. Laboratory tests were performed at baseline and at one, 3 and 6 months visits. Adverse events were reported by the patient on interview at each visit. Evaluation of the outcome variables indicated that both groups showed statistically significant improvements (p<0.001) after 15 days treatment in both OSI and VAS as well as in knee function which were sustained for the 6 month study period. Knee flexion also improved. There were no statistically significant differences in efficacy between the 2 groups. The number of treatment withdrawals due to adverse events (mainly gastrointestinal) were 14 and 27 for the AC and DC groups, respectively, which differed significantly between groups (p=0.027). Among these, 5 patients in the DC group, and only one in the AC group, were withdrawn because of elevated levels of liver enzymes. These data indicate that while AC and DC have similar efficacy in OA, AC is significantly better tolerated.
Effects of honey and sucrose on longevity and fecundity of apanteles metesae (Nixon), a major parasitoid of the oil Palm Bagworm, Metisa Plana (Walker)

The effects of various concentrations of honey and sucrose on the longevity and fecundity of Apanteles metesae (Nixon), an endoparasitoid of oil palm bagworm, Metisa plana (Walker) (Lepidoptera: Psychidae) were studied in the laboratory. Our results showed that there were a significant difference (p<0.05) in the longevity of metesae fed on various concentrations of honey solutions. Longevity of A. metesae was significantly longer when fed on 50% honey than on pure honey. Nonetheless, longevity of metesae females fed on 50% honey was relatively longer than other honey concentrations. The parasitoid lived significantly longer when fed on 20% sucrose than when fed on 50% sucrose and distilled water. However, the parasitoid fed on 50% honey had a longevity that was statistically similar to 20% sucrose and 50% sucrose. Fecundity of metesae differed significantly (p<0.05) when fed on 50% honey, 20% sucrose and 50% sucrose. The highest and lowest fecundity was when the parasitoids fed on 20% sucrose and distilled water, respectively. Overall, the result showed that 20% sucrose was a more suitable diet for metesae females as compared with other diets.
Anabolic Androgenic Steroid use in the Nordic Countries: A Reply to Bilgrei and Sand⊘y

Introduction In commenting on our systematic review and meta-analysis of the prevalence of use of non-medical anabolic androgenic steroid(s) (AAS) in the Nordic countries (Sagoe, Torsheim, Molde, Andreassen, & Pallesen, 2015a), Bilgrei and Sandøy (2015) argue that AAS use in these countries should not be considered a major public health problem. Instead, they argue that AAS use in the Nordic countries should be regarded as a problem among smaller subgroups of users. Although Bilgrei and Sandøy provide a useful contribution to the discussion on the use of AAS in the Nordic countries, it is our view that their comments have little impact on our conclusion: “. though subject to some limitations.non-medical AAS use should be regarded as a serious public health problem in the Nordic countries” (p. 7). In this piece, we respond to the comments of Bilgrei and Sandøy based on the premises they provide for their conclusion: prevalence, evolvement and severity.
HUMAN PLASMA CETP DEFICIENCY : IDENTIFICATION OF A NOVEL MUTATION IN EXON 9 OF THE CETP GENE IN A CAUCASIAN SUBJECT FROM NORTH AMERICA

Human plasma cholesteryl ester transfer protein (CETP) is a 476-residue hydrophobic glycoprotein that catalyzes the heterotransfer of cholesteryl esters and triacylglycerols among lipoproteins: Mutations in the CETP gene have been identified, mostly in the Japanese population. These mutations result in hypercholesterolemia due to the presence of large cholesteryl ester-rich HDL particles, elevated plasma apoA-I and apoE, and reduced apoB levels. Here we report the plasma lipoprotein phenotype and molecular defect in a 57-year-old female Nova Scotian subject lacking Japanese ancestry who is homozygous for a novel mutation in the CETP gene. Her total plasma cholesterol was 7.3 mmol/l with an LDL cholesterol of 2.9 mmol/l and HDL cholesterol of 4.4 mmol/l. She was mildly hypertriglyceridemic (1.6 mmol/l) and had markedly elevated apoA-I (256 mg/dl) and apoE (14.4 mg/dl) with only slightly reduced apo/B levels (94 mg/dl). Her VLDL and LDL were cholesteryl ester-poor (1.8 and 37.2% of lipids, respectively) and triacylglycerol-rich (67.3 and 18.9% of lipids, respectively) while her HDL was cholesteryl ester-rich (40.2-45.7% of lipids) and triacylglycerol-poor (3.3-2.5% of lipids). No plasma CETP activity or mass was detected. Bi-directional DNA sequence analysis of PCR products from all 16 exons showed a single base substitution (C-->T at nucleotide 836 in exon 9 resulting in 268 Arg-->STOP) in both alleles. No other mutation was detected. A single base mismatched, 26 bp reverse PCR primer that produced a single Mae III RFLP site upon amplification of the mutated DNA sequence was designed for rapid population screening. This subject is, we believe, the first Caucasian North American patient reported to have CETP deficiency.
Questions and controversies in the study of time-varying functional connectivity in resting fMRI

Abstract The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge of the spatiotemporal organization of these interactions is critical for establishing a solid understanding of the brain’s functional architecture and the relationship between neural dynamics and cognition in health and disease. The possibility of studying these dynamics through careful analysis of neuroimaging data has catalyzed substantial interest in methods that estimate time-resolved fluctuations in functional connectivity (often referred to as “dynamic” or time-varying functional connectivity; TVFC). At the same time, debates have emerged regarding the application of TVFC analyses to resting fMRI data, and about the statistical validity, physiological origins, and cognitive and behavioral relevance of resting TVFC. These and other unresolved issues complicate interpretation of resting TVFC findings and limit the insights that can be gained from this promising new research area. This article brings together scientists with a variety of perspectives on resting TVFC to review the current literature in light of these issues. We introduce core concepts, define key terms, summarize controversies and open questions, and present a forward-looking perspective on how resting TVFC analyses can be rigorously and productively applied to investigate a wide range of questions in cognitive and systems neuroscience.
Non Infantile Desmoplastic Astrocytoma: a case Report

Desmoplastic infantile astrocytomas (DIA) are huge cerebral masses with cystic and solid components in infants with a benign course. Less than 50 cases of have been reported in the literature and most of the cases are children below 24 months. We are presenting a rare case of DIA which presented at the age of 4 years with vomiting and headache in neurosurgical OPD. He was diagnosed with a huge left temporal parietal tumor with midline shift which on histopathological examination was confirmed as DIA. Patient was operated and had good recovery and was followed up for two years.
The impact of high-intensity laser therapy on oxidative stress, lysosomal enzymes, and protease inhibitor in athletes

The aim of the study was to assess the effect of one session of high-intensity laser therapy (HILT) on the levels of selected oxidative stress parameters, lysosomal hydrolases, and anti-inflammatory serine protease inhibitor in the peripheral blood of amateur athletes with torn or pulled tendons of the ankle or the knee joint. The group of injured athletes comprised 16 males and females aged 16.3 ± 1.3 years, while the control group of 14 healthy, noninjured amateur athletes of both sexes (controls; age 17.4 ± 4.6 years). Material for the study was peripheral blood taken at three study time points: Immediately before, 30 min after, and 24 h after HILT intervention. In plasma and erythrocytes, thiobarbituric acid reactive substances (TBARSpl and TBARSer, respectively) were determined. In erythrocytes, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were measured. In serum, the activity of acid phosphatase (AcP), arylsulfatase (ASA), cathepsin D (CTS D), and α1-antitrypsin (AAT) were determined. Among oxidative stress parameters, only the CAT activity significantly decreased 24 h after HILT compared to measurement 30 min after the treatment in the injured individuals (P < 0.01), while the GPx activity in that group was meaningfully higher 30 min after HILT compared to controls (P < 0.05). Thirty min after the intervention, the activities of AcP and ASA were lower in the injured participants compared to the uninjured ones (P < 0.01 and P < 0.05, respectively). The CTS D activity was lower 30 min and 24 h after HILT in both groups (P < 0.001) and did not differ significantly between them (P > 0.05). Moreover, the study showed statistically significant linear relationships between the TBARSer concentration and the SOD activity before HILT in the healthy participants (r = -0.6, P = 0.021) and 24 h after HILT in the injured ones (r = 0.6, P = 0.025). In the noninjured athletes before HILT, the CTS D activity linearly correlated with the AAT activity (r = -0.70, P = 0.005), and 30 min after the treatment, with the AcP activity (r = 0.5, P = 0.041). 24 h after the HILT intervention, the CTS D and AcP activities were also correlated in the injured athletes (r = 0.8, P = 0.002). The study suggests that one HILT intervention does not significantly influence the redox equilibrium but stabilizes lysosomal membranes.
GATA-binding protein 3 and androgen receptor expressions in invasive breast cancer: the relationship with molecular phenotypes, disease progression, and survival outcomes

Breast cancer (BC) is considered as one of the most frequent cancers worldwide. GATA3 plays a crucial role in promoting proliferation and differentiation in many tissues including breast. Loss of GATA3 expression in BC has been associated with aggressive tumors and poor prognosis. Androgen receptor (AR) has been reported to be involved in differentiation, development, and regulation of breast cell growth. The aim of this study was to investigate the immunohistochemical expressions of GATA3 and AR and their relationships with different clinicopathological features and molecular phenotypes and to further evaluate their prognostic significance. Immunohistochemical expressions of GATA3 and AR were evaluated in 61 formalin-fixed and paraffin-embedded tissue specimens of invasive duct carcinoma. Positive GATA3 immunostaining was detected in 54.1% of cases and showed significant associations with lower tumor grade (P=0.007), estrogen receptor (ER)-positive expression (P=0.000), progesterone receptor-positive expression (P=0.001), and good and moderate Nottingham prognostic index (P=0.012). No significant relationship was found between GATA3 expression and other clinicopathological parameters. Positive AR expression was detected in 60.7% of cases and showed positive significant associations with lower tumor grade (P=0.005), ER-positive expression (P=0.0001), progesterone receptor-positive expression (P=0.001), and good and moderate Nottingham prognostic index (P=0.011). No significant relationship could be found between AR expression and other clinicopathological features. Higher rates of positive GATA3 and AR expressions were observed in luminal A and luminal B phenotypes, but negative expressions of GATA3 and AR were observed frequently in HER2 and triple-negative breast cancer subgroups (P=0.001 and 0.001, respectively). To determine the immunoprofile of the examined tumors, cases were stratified according to the joint expression status of GATA3 and AR. This study has found a highly significant positive correlation between the expressions of GATA3 and AR (r=0.99, P<0.0001). Univariate survival analyses demonstrated that cases expressing positive GATA3 and AR had a significantly longer relapse-free survival and better clinical outcomes than those with negative expressions (log-rank P=0.0000 and ˂0.0001, respectively). Cox multivariate regression analysis has selected ER (P=0.015), stage (P=0.014), AR (P=0.003), and combined GATA3/AR immuonoexpressions (P=0.048) as independent prognostic indicators. Altogether, our findings suggest that AR and combined GATA3/AR immunoexpressions can serve as independent good prognostic biomarkers in BC.
Intraoperative identification of parathyroid tissue: a comparative validity study of frozen section, cytology, and reflected-light diagnostic methods

Background Surgery is the main line of treatment for hyperparathyroidism, but preliminary localization of the lesion is essential. This could be accomplished preoperatively by radiographic methods (isotope scans and ultrasonography) or intraoperatively by pathologic methods, namely, frozen section, cytology, and reflected-light microscopy. Aim To compare the diagnostic accuracy of the intraoperative pathologic methods when used singly or combined. The study was done on 30 (10 parathyroid tissue and 20 nonparathyroid tissue) tissue samples, obtained from nine patients. Modifications were made on a monocular microscope to allow transmitted-light, reflected-light, and digital photography. Results When used alone, the diagnostic accuracy was 96.6% for frozen section, 86.6% for cytology, and 80% for reflected-light microscopy. The combined use of cytology with reflected-light microscopy increased the diagnostic accuracy to 93.3%, with good concordance with the accuracy of frozen section combined with cytology (κ ratio 0.651). Diagnostic errors were mainly owing to the difficulty to differentiate thyroid from parathyroid tissue. Conclusion In specialized centers, frozen section combined with cytology is the method of choice for the intraoperative diagnosis of parathyroid tissue. Conversely, in developing countries, where frozen section equipment is usually not available, combination of reflected-light microscopy and cytology is a good, inexpensive, rapid and effective alternative. However, proper training is needed for these methods to ensure an accurate diagnosis.
Prevalence of skin diseases in children admitted to mersin university school of medicine, dermatology clinic

Objective: Skin disorders constitute an important problem in children living in developing countries. The aim of the study was to evaluate the prevalence of skin diseases in children aged 0–16 years. Materials and Methods: In the present study, data on a total of 12,206 children aged 0–16 years, admitted to the outpatient clinic of Dermatology Department, Mersin University School of Medicine, between 2001 and 2010 were analyzed. Results: Male/female ratio was 1.1/1. 44.2% of the patients were adolescents. The most common diseases were acne (12.4%), warts (10.5%), and atopic dermatitis (9.3%). Conclusion: Studies of the pediatric population, which constitutes the cornerstone of the community, can play an important role in determining the policies of protective medicine and public health.
Immunohistochemical study on Fascin-1 and Ki-67 as potentially poor prognostic marker in prostatic carcinoma

Background Prostatic carcinoma remains one of the most prevalent cancers among men and a major source for morbidity and mortality. Fascin-1 is significantly elevated in advanced stage and lymph node metastasis and has great prognostic values in head and neck squamous cell and colorectal cancers. Ki-67 expression is the tissue biomarker with the most consistent association with the clinical outcomes of prostatic carcinoma. Aim To evaluate the immunohistochemical expression pattern of Fascin-1 and Ki-67 and correlate the results with clinicopathological parameters. Materials and methods A retrospective study was carried on 80 cases of prostatic carcinoma. Immunohistochemical staining with monoclonal Fascin-1 and Ki-67 antibody was performed. Results Fascin-1 expression was positive in 90% of cases of prostatic carcinoma. There was a statistical relationship between Fascin-1 expression and prostatic-specific antigen level, Gleason score, lymphovascular and perineural invasion. Ki-67 expression was positive in 98.75% and showed positive statistical relationship with Gleason score and lymphovascular and perineural invasion. A positive relationship was found between Fascin-1 expression and Ki-67 expression in tumor cells. Conclusion Fascin-1 and Ki-67 expression tend to increase with more aggressive prostatic carcinoma. They may be used as a prognostic marker to predict poor outcome in patients with prostatic carcinoma.