Miracle-dz/UniFAR-FTUs huggingface dataset:
Romantic Partner Perspectives of the Relational Context of Weight Loss Support

ABSTRACT Much of the research on romantic partner support of weight loss takes the perspective of targets pursuing weight loss. This study, however, assesses the perspectives of the partners providing support, and specifically their perceptions of the relational context and their support strategy use. An MTurk sample of 283 partners of individuals trying to lose weight reported on relational context characteristics (i.e., having a team effort, opposing approaches, and imposition regarding the weight loss pursuits) and their use of encouragement, direct influence, and coercion. Analyses largely supported the hypotheses regarding the associations between the relational characteristics and strategy use. For example, higher team effort and lower opposing approaches about weight management were linked with more encouragement, and greater opposing approaches and imposition were associated with more coercion. Four relational weight loss climates based on the collective of these characteristics were also linked with strategy use. All associations were found after accounting for general relationship satisfaction as well as other control variables. Overall, the findings suggest that perceptions of the weight loss in the context of the relationship were connected to the strategies partners employed in helping targets achieve weight loss. Because strategies vary in effectiveness, understanding which relational characteristics, as well as which broader relational climates, facilitate partner strategy choice can ultimately help augment individuals’ weight loss success.
Generating mnemonics boosts recall of chemistry information.

Students frequently generate mnemonic cues to help them remember difficult or abstract information (Tullis & Maddox, Metacognition and Learning, 2020, 15, 129). Self-generated mnemonics have the potential to be particularly effective means of remembering target information because they can transform abstract information into meaningful units, connect information to existing schema, and create distinct retrieval routes to the targets. Across five experiments, we compared the effectiveness of self-generated mnemonics to mnemonics generated by others for remembering chemistry information. Generating one's own mnemonics consistently boosted recall for both the chemistry content and the mnemonic itself. However, experimentally boosting recall of mnemonics through retrieval practice did not affect recall of associated chemistry content. These results indicate that improved recall of chemistry content is not caused by better recall of the mnemonic itself; rather, generating a mnemonic involves deep and effortful processing of chemistry content that boosts recall more than reading someone else's mnemonic. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences

ABSTRACT There is a growing consensus that cognitive assessments should form part of routine clinical care in Multiple Sclerosis (MS). However, what remains unclear is which assessments are preferred by “stakeholders” (including people with MS, family members, charity volunteers, clinicians, and healthcare commissioners), in which contexts, and in which formats. Therefore, the aim of this study was to collect and synthesize stakeholders’ perceptions of the assessments that are acceptable and feasible for routine administration in the UK healthcare system. We interviewed 44 stakeholders and held one focus group (n = 5). We asked stakeholders about their experience with cognitive impairment and assessment and their views on how cognitive assessment could be implemented within routine clinical care. Using framework analysis, we summarized three themes: the current cognitive screening situation; the suitability of commonly used assessments; and feasibility aspects, including modality and location of testing. All participants acknowledged that cognitive impairment could have a significant impact on the quality of life, but that assessment and monitoring are not routinely performed in clinics. Barriers and enablers were described, and most participants reported that brief, routine screening with tests such as symbol substitution was acceptable. Electronic, self-administration of cognitive screening would be beneficial in minimizing clinic attendance and staff time.
Ethanol-assisted kneading of apigenin with arginine for enhanced dissolution rate of apigenin: development of rapidly disintegrating tablets

Abstract Apigenin is a natural flavonoid which is claimed to have many pharmacological activities ranging from simple anti-inflammatory to anticancer action. However, poor dissolution slowed the advancement of this drug through the development pipelines. The objective of this work was to probe ethanol-aided kneading of apigenin with arginine as a new strategy for enhanced dissolution rate. The work was extended to develop rapidly disintegrating tablets of apigenin. Apigenin was mixed with increasing molar ratios of arginine before ethanol-aided kneading. The resulting products were examined using Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction in addition to probing the dissolution characteristics of apigenin. The analytical techniques highlighted the existence of new crystalline species with a possibility of salt formation. The recorded alterations in the crystalline properties were associated with a significant enhancement in the dissolution rate of apigenin. The presence of arginine did not have any negative effect of the cytotoxic power of apigenin. Optimum formulation was successfully prepared as rapidly disintegrating tablets which showed fast liberation of apigenin. The study introduced arginine as a potential excipient for enhanced dissolution of apigenin after ethanol-assisted kneading. Graphical Abstract
Urine metabolomic biomarkers for prediction of isolated fetal congenital heart defect

Abstract Objective To identify maternal second and third trimester urine metabolomic biomarkers for the detection of fetal congenital heart defects (CHDs). Study design This was a prospective study. Metabolomic analysis of randomly collected maternal urine was performed, comparing pregnancies with isolated, non-syndromic CHDs versus unaffected controls. Mass spectrometry (liquid chromatography and direct injection and tandem mass spectrometry, LC–MS–MS) as well as nuclear magnetic resonance spectrometry, 1H NMR, were used to perform the analyses between 14 0/7 and 37 0/7 weeks gestation. A total of 36 CHD cases and 41 controls were compared. Predictive algorithms using urine markers alone or combined with, clinical and ultrasound (US) (four-chamber view) predictors were developed and compared. Results A total of 222 metabolites were identified, of which 16 were overlapping between the two platforms. Twenty-three metabolite concentrations were found in significantly altered in CHD gestations on univariate analysis. The concentration of methionine was most significantly altered. A predictive algorithm combining metabolites (histamine, choline, glucose, formate, methionine, and carnitine) plus US four-chamber view achieved an AUC = 0.894; 95% CI, 0814–0.973 with a sensitivity of 83.8% and specificity of 87.8%. Enrichment pathway analysis identified several lipid related pathways that are dysregulated in CHD, including phospholipid biosynthesis, phosphatidylcholine biosynthesis, phosphatidylethanolamine biosynthesis, and fatty acid metabolism. This could be consistent with the increased risk of CHD in diabetic pregnancies. Conclusions We report a novel, noninvasive approach, based on the analysis of maternal urine for isolated CHD detection. Further, the dysregulation of lipid- and folate metabolism appears to support prior data on the mechanism of CHD.
Psychosocial Factors Associated with E-Cigarette Use among Young Adults in a 4-Year University in Appalachia

Abstract Young adults (ages 18-25) have the highest rate of e-cigarette use, or vaping, among any other age group. College students make up a large portion of young adults and are on the forefront of cultural substance use patterns. Objectives In order to determine methods to reduce vaping prevalence, motivations for use and co-occurring health behaviors and disorders need to be determined. This study investigated vaping characteristics and associated health behaviors in a young adult Appalachian college population. Methods Students attending an Appalachian university were invited to participate in an online survey measuring their use of e-cigarettes, motivations for use, mental health, and Adverse Childhood Experiences (ACEs). Analysis included prevalence of e-cigarette use and associations between e-cigarette use and Appalachian identity, mental health, and ACEs. Results Participants (N = 3398) stated that the most common motivator for using e-cigarettes was to decrease stress, followed by the good taste, friends’ usage, and wanting to quit cigarettes. E-cigarette use was associated with alcohol use, anxiety, depression, stress, and Adverse Childhood Experiences (ACEs) and these variables were placed into a full logistic regression model, in which anxiety and stress were no longer significant, and alcohol use was the strongest association (OR 1.36 95% CI 1.35-1.42, p<.0001). Conclusions/importance: Findings demonstrate a need for efforts to reduce e-cigarette use to focus on the co-use of alcohol, co-occurring mental health disorders, and the social and enjoyment motivations for use.
Potential promotion of activated carbon supported nano zero-valent iron on anaerobic digestion of waste activated sludge

ABSTRACT A large amount of waste activated sludge (WAS) harms the ecological environment, and anaerobic digestion (AD) is an effective method for WAS treatment. In this study, activated carbon (AC)/ nano zero-valent iron (NZVI) was synthesized by a liquid-phase reduction method, and was used to boost methane production. The associated mechanisms and effects of additives on AD during the addition and removal stage were investigated systematically. Compared to the blank group, the cumulative methane production was increased by 14.3%, 26.3% and 34.1% in the groups of AC, NZVI and AC/NZVI, respectively. The addition of AC/NZVI significantly increased the concentration of VFAs and promoted the hydrolysis and acidification of WAS. After the AD of the additives addition stage was finished, the additives were removed and the sludge was replenished in all groups, the methanogenesis performance of the experimental groups was significantly inhibited. The cumulative methane production in the AC and AC/NZVI groups was 21.7% and 13.5% lower than the blank group, respectively. The experimental results have a good correlation with curve fitting by the modified Gompertz model. The modified Gompertz model found that AC, NZVI and AC/NZVI increased the methanogenic potential and maximum methane production rate of WAS, but also prolonged the lag-phase time. AC/NZVI might play a role in coupling effects. It could not only maintain the original characteristics of NZVI and increase its stability, but also develop the advantages of AC promoting direct interspecies electron transfer. Microbial community analysis indicated that the abundance of hydrogenotrophic methanogens was enriched by AC/NZVI. GRAPHICAL ABSTRACT
Donor‐defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium

Chronic nontuberculous mycobacterial infections with Mycobacterium avium and Mycobacterium intracellulare complicate bronchiectasis, chronic obstructive airway disease, and the health of aging individuals. These insidious intracellular pathogens cause considerable morbidity and eventual mortality in individuals colonized with these bacteria. Current treatment regimens with antibiotic macrolides are both toxic and often inefficient at providing infection resolution. In this article, we demonstrate that human marrow‐derived mesenchymal stem cells are antimicrobial and anti‐inflammatory in vitro and in the context of an in vivo sustained infection of either M. avium and/or M. intracellulare.
Primary healthcare workers at risk during COVID-19: An analysis of infections in HIV service providers in five districts of South Africa.

BACKGROUND Protecting healthcare workers (HCWs) from COVID-19 is a global priority. Anova Health Institute (Anova) is the PEPFAR (US President's Emergency Plan for AIDS Relief) District Support Partner for the Johannesburg, Cape Town, Sedibeng, Capricorn and Mopani districts in South Africa, operating in public sector primary healthcare facilities. At the time of the emergence of COVID-19, Anova employed close to 4 000 people: 41% community health workers (CHWs), 23% data staff, 20% nurses and doctors, 12% management/support and 5% allied HCWs. OBJECTIVES To describe rates of COVID-19 diagnosis in Anova-employed HCWs in five districts. METHODS Employees exposed to, tested for or diagnosed with COVID-19 were required to report the event. These reports were compiled into a database to monitor the impact of COVID-19 on the workforce. We kept a timeline of key events occurring at national and district level, including Anova's policies and their implementation, that was used to describe organisational response. We described the number of confirmed cases, cumulative incidence rates and testing rates, broken down by district and job category. We estimated expected deaths and the effect on time off work. RESULTS Of Anova employees, 14% (n=562) were diagnosed with COVID-19 by the end of September 2020. Cumulative incidence was highest in Sedibeng (29%) and lowest in Mopani (5%). All HCWs experienced high incidences: data staff 17%, allied HCWs 16%, CHWs 14%, nurses and doctors 13%, and management/support 11%. At the peak of the epidemic, for 5 weeks, >5% of employees were unable to work owing to exposure or infection, significantly disrupting service delivery. The additional administrative burden on managers was substantial. CONCLUSIONS It is critical that all cadres of HCWs are protected in the workplace, including in primary care settings, where better structuresare needed to perform risk assessments and conduct outbreak investigations. CHWs and data staff may be at higher risk owing to poor infrastructure, limited power to negotiate working conditions, and limited experience of infection prevention and control. Their working conditions must be improved to reduce their risk.
Computational flow cytometry as a diagnostic tool in suspected‐myelodysplastic syndromes

The diagnostic work‐up of patients suspected for myelodysplastic syndromes is challenging and mainly relies on bone marrow morphology and cytogenetics. In this study, we developed and prospectively validated a fully computational tool for flow cytometry diagnostics in suspected‐MDS. The computational diagnostic workflow consists of methods for pre‐processing flow cytometry data, followed by a cell population detection method (FlowSOM) and a machine learning classifier (Random Forest). Based on a six tubes FC panel, the workflow obtained a 90% sensitivity and 93% specificity in an independent validation cohort. For practical advantages (e.g., reduced processing time and costs), a second computational diagnostic workflow was trained, solely based on the best performing single tube of the training cohort. This workflow obtained 97% sensitivity and 95% specificity in the prospective validation cohort. Both workflows outperformed the conventional, expert analyzed flow cytometry scores for diagnosis with respect to accuracy, objectivity and time investment (less than 2 min per patient).
Vibrotactile Feedback System From the Fingertip to the Temples for Perceptual Enhancement of Contracture Palpation

Contractures are generally assessed by a physician or physical therapist through palpation. However, contracture palpation requires skill and experience. The frictional vibration, which has a pulse-like vibration due to sliding disturbances around the affected area during palpation, is important in assessing the degree of contracture progression. This paper aims to enhance the perceptual sensitivity of frictional vibration for contracture palpation using a vibrotactile feedback system. We previously proposed an evaluation system for palpation with a wearable skin vibration sensor that detects skin-propagated vibration, allowing touch with a bare fingertip. In this paper, we propose the vibrotactile feedback system that presents the tactile information of the fingertip detected by the wearable tactile sensor to the temples with a vibrotactile display. A stimulator that gives vibrations similar to those during the palpation, which include pulse-like vibration and small vibration, was assembled. Then, psychophysical experiments on the vibrotactile feedback system were conducted using this stimulator. The results showed that the detection sensitivity of the pulse-like vibration was significantly enhanced with the feedback.
Intra‐tracheal surfactant/budesonide versus surfactant alone: Comparison of two consecutive cohorts of extremely preterm infants

To compare the efficacy of intra‐tracheal (IT) surfactant/budesonide (SB) with that of surfactant alone (S) in reducing the rate of bronchopulmonary dysplasia (BPD) at 36 weeks post‐menstrual age (PMA), we included extremely preterm very low birth weight (VLBW) infants with severe respiratory distress syndrome (RDS) in our tertiary neonatal level of care unit (Padua, Italy).
Relationship Between Optical Coherence Tomography Parameter and Visual Function in Eyes With Epiretinal Membrane

Purpose To investigate the associations between visual function and the optical coherence tomography (OCT) parameters in eyes with idiopathic epiretinal membrane (ERM). Methods Thirty-nine consecutive eyes with ERM were enrolled. In addition to OCT parameters, such as central retinal thickness (CRT), the area of gap between the ERM and the retinal surface (SUKIMA) was newly defined and calculated from the vertical and horizontal OCT images (SUKIMAv and SUKIMAh). The average of SUKIMAv and SUKIMAh (SUKIMAave) was used for the statistical analysis. The vertical and horizontal metamorphopsia scores (MV, MH) and the average of MV and MH (Mave) were also used for the analysis. Results The Mave was not significantly associated with logMAR visual acuity (VA) (P = 0.57, linear regression analysis). Analysis using second-order bias-corrected Akaike information criterion model selection identified the age, CRT, and SUKIMAave as being associated with logMAR VA. On the other hand, among the OCT parameters, SUKIMAave and CRT were associated with the Mave. In addition, there was a significant relationship between SUKIMAh and MV (P = 0.011) and between SUKIMAv and MH (P = 0.0014). Conclusions We identified SUKIMA as a novel OCT parameter that is useful to predict both VA and metamorphopsia in patients with ERM.
Linguistic processing of task-irrelevant speech at a cocktail party

Paying attention to one speaker in a noisy place can be extremely difficult, because to-be-attended and task-irrelevant speech compete for processing resources. We tested whether this competition is restricted to acoustic-phonetic interference or if it extends to competition for linguistic processing as well. Neural activity was recorded using Magnetoencephalography as human participants were instructed to attend to natural speech presented to one ear, and task-irrelevant stimuli were presented to the other. Task-irrelevant stimuli consisted either of random sequences of syllables, or syllables structured to form coherent sentences, using hierarchical frequency-tagging. We find that the phrasal structure of structured task-irrelevant stimuli was represented in the neural response in left inferior frontal and posterior parietal regions, indicating that selective attention does not fully eliminate linguistic processing of task-irrelevant speech. Additionally, neural tracking of to-be-attended speech in left inferior frontal regions was enhanced when competing with structured task-irrelevant stimuli, suggesting inherent competition between them for linguistic processing.
Exploring a Hidden Epidemic: Drowning Among Adults Aged 65 Years and Older

Objectives: To explore trends in unintentional fatal drowning among older adults (65 years and older). Methods: Total population retrospective analysis of unintentional fatal drowning among people aged 65 years and older in Australia, Canada and New Zealand (2005–2014) was conducted. Results: 1459 older adults died. Rates ranged from 1.69 (Canada) to 2.20 (New Zealand) per 100,000. Trends in crude drowning rates were variable from year to year. A downward trend was observed in New Zealand (y = −.507ln(x) + 2.9918), with upward trends in Australia (y = .1056ln(x) + 1.5948) and Canada (y = .1489ln(x) + 1.4571). Population projections suggest high annual drowning deaths by 2050 in Australia (range: 120–190; 1.69–2.76/100,000) and Canada (range: 209–430; 1.78–3.66/100,000). Significant locations and activities associated with older adult drowning differed by country and age band. Conclusions: Drowning among older adults is a hidden epidemic claiming increasing lives as the population ages. Targeted drowning prevention strategies are urgently needed in Australia, Canada, New Zealand and other similar countries.
Biallelic splicing variants in the nucleolar 60S assembly factor RBM28 cause the ribosomopathy ANE syndrome

Significance RBM28 is a human protein essential for proper assembly of the large ribosomal subunit, crucially enabling synthesis of all cellular proteins. Defects in RBM28 cause rare ribosomopathies: alopecia, neurological defects, and endocrinopathy (ANE) syndrome. We investigated an ANE syndrome patient with a clinical presentation consistent with the definition of ANE syndrome but possessing differing genetic variants and molecular pathology. We find one inherited allele is null, clarifying that ANE syndrome is not caused by RBM28 haploinsufficiency, while the other inherited allele retains enough function to enable survival but preclude proper development. Our results define an underlying pathology of ANE syndrome, further delineating an emerging class of assembly factor ribosomopathies and underscoring the importance of nucleolar processes in human health. Alopecia, neurologic defects, and endocrinopathy (ANE) syndrome is a rare ribosomopathy known to be caused by a p.(Leu351Pro) variant in the essential, conserved, nucleolar large ribosomal subunit (60S) assembly factor RBM28. We report the second family of ANE syndrome to date and a female pediatric ANE syndrome patient. The patient presented with alopecia, craniofacial malformations, hypoplastic pituitary, and hair and skin abnormalities. Unlike the previously reported patients with the p.(Leu351Pro) RBM28 variant, this ANE syndrome patient possesses biallelic precursor messenger RNA (pre-mRNA) splicing variants at the 5′ splice sites of exon 5 (ΔE5) and exon 8 (ΔE8) of RBM28 (NM_018077.2:c.[541+1_541+2delinsA]; [946G > T]). In silico analyses and minigene splicing experiments in cells indicate that each splice variant specifically causes skipping of its respective mutant exon. Because the ΔE5 variant results in an in-frame 31 amino acid deletion (p.(Asp150_Lys180del)) in RBM28 while the ΔE8 variant leads to a premature stop codon in exon 9, we predicted that the ΔE5 variant would produce partially functional RBM28 but the ΔE8 variant would not produce functional protein. Using a yeast model, we demonstrate that the ΔE5 variant does indeed lead to reduced overall growth and large subunit ribosomal RNA (rRNA) production and pre-rRNA processing. In contrast, the ΔE8 variant is comparably null, implying that the partially functional ΔE5 RBM28 protein enables survival but precludes correct development. This discovery further defines the underlying molecular pathology of ANE syndrome to include genetic variants that cause aberrant splicing in RBM28 pre-mRNA and highlights the centrality of nucleolar processes in human genetic disease.