Miracle-dz/UniFAR-FTUs huggingface dataset:
Fewer Dimensions, More Structures for Improved Discrete Models of Dynamics of Free versus Antigen-Bound Antibody

Over the past decade, Markov State Models (MSM) have emerged as powerful methodologies to build discrete models of dynamics over structures obtained from Molecular Dynamics trajectories. The identification of macrostates for the MSM is a central decision that impacts the quality of the MSM but depends on both the selected representation of a structure and the clustering algorithm utilized over the featurized structures. Motivated by a large molecular system in its free and bound state, this paper investigates two directions of research, further reducing the representation dimensionality in a non-parametric, data-driven manner and including more structures in the computation. Rigorous evaluation of the quality of obtained MSMs via various statistical tests in a comparative setting firmly shows that fewer dimensions and more structures result in a better MSM. Many interesting findings emerge from the best MSM, advancing our understanding of the relationship between antibody dynamics and antibody–antigen recognition.
Simple method for quality factor estimation in resonating MEMS structures

The quality factor of a packaged MEMS resonating structure depends on both the packaging pressure and the structure’s proximity to the walls. This type of mechanical constraints, which causes energy dissipation from the structure to the surrounding air, are applicable for oscillating energy harvesters and should be considered in the design process. However, the modelling of energy losses or the measurements of their direct influence inside a packaged chip is not trivial. In this paper, a simple experimental method to quantify the energy loss in an oscillating MEMS structures due to the surrounding air is described together with preliminary results. The main advantage of the method is the ability to characterize the damping contributions under different vacuum and packaging conditions without requiring any packaging of the harvester chip or fabrication of multiple devices with different cavity depths.
Factors Associated With Depression and Anxiety in Korean Adolescents During the COVID-19 Pandemic

Objective This study was performed to identify factors associated with depression and anxiety among Korean adolescents during the coronavirus disease (COVID-19) pandemic. Methods We conducted a cross-sectional study of 1,898 Korean adolescents (55.2% male, 44.8% female) ranging in age from 12 to 17 years (mean±standard deviaion age, 15.4±2.6 years). Depression and anxiety were defined as a Patient Health Questionnaire-9 score ≥10 and Generalized Anxiety Disorder-7 score ≥10, respectively. Other questionnaires included sociodemographic data, psychosocial stresses, and experiences in association with COVID-19. Psychiatric scales included Gratitude Questionnaire-6, Perceived Stress Scale-10, and UCLA Loneliness Scale-3. Results The prevalence rates of depressive and anxiety symptoms among participants were 13.8% and 21.0%, respectively. Multivariable logistic regression analysis revealed that female sex, fear of COVID-19 infection, low gratitude were risk factors for depression. Fear of COVID-19 infection, increased TV watching time, and academic-related stress were risk factors for anxiety. Conclusion Depression and anxiety were prevalent during the pandemic in Korean adolescents, and were associated with fear of COVID-19 infection. Providing appropriate information on COVID-19, helping adolescents manage academic-related stress and maintain daily life patterns, and implementing interventions to foster gratitude are important for preventing depression and anxiety in Korean adolescents.
Highly Photoactive Polythiophenes Obtained by Electrochemical Synthesis from Bipyridine-Containing Terthiophenes

According to numerous previous reports, a Z-scheme with two photon absorbers is the most promising strategy to achieve artificial photosynthesis, but in addition to two efficient catalysts — one for oxygen evolution, the other for CO2 reduction — two different and complementary semiconducting sensitizers are required. Here we present the synthesis of two bipyridine-functionalized terthiophenes, which can be electropolymerized to give photoactive p-type semiconductors the capability to perform as photocathode in photoelectrochemical cells for water photosplitting or artificial photosynthesis. Indeed the bipyridine moiety in their structure allows the binding of transition metal carbonyl complexes employed in CO2 reduction, and their band-gap is suitable for the coupling with wide band-gap semiconductors, which have already found application as photoanodes. Finally, they are characterized by photogenerated charge carrier density between 1.1 and 1.4 × 1019 cm−3, with first-order recombination constant of 0.7–1.8 × 10−2 s−1. These figures are of the same order of magnitude of their inorganic counterparts and would therefore guarantee photoconductivity of the device and the activation of the organometallic catalysts with which they should be coupled to function as photocathodes for CO2 reduction.
Preimplantation Genetic Testing Guidelines of International Society of Reproductive Genetics

The International Society of Reproductive Genetics (ISRG) assembled a workgroup made up of clinicians, clinical laboratory directors, and scientists for the purpose of creating the guidelines for preimplantation genetic testing (PGT). The most up-to-date information and clinical insights for the optimal PGT practice were incorporated in these guidelines. Recommendations are provided for embryologists, medical geneticists, clinical laboratorians, and other healthcare providers to improve the wellbeing of patients seeking assisted reproductive treatment and their offspring.
Access to Care for US Children with Co-Occurrence of Autism Spectrum Disorder and Epilepsy

Epilepsy is a common comorbidity among children with autism spectrum disorder (ASD). There is a lack of understanding of the inequality in access to care for children with co-occurring ASD and epilepsy (ASD-EP). The purpose of this study is to examine key indicators for access to care and care coordination for children with ASD-EP in the US National Survey of Children’s Health (NSCH). Data were collected from the 2017–2019 NSCH. Our analytic sample included children with ASD without epilepsy (N = 2150), children with both ASD and epilepsy (N = 143), and children with epilepsy without ASD (N = 711). The dependent variables included important access to care indicators such as having usual sources of care, having adequate coverage, being frustrated in efforts to get service, and receiving care coordination. The independent variables included ASD-EP status, child demographics, and an intellectual disability (ID) diagnosis. Our results show that demographic characteristics such as sex, race, income level, and insurance type affect access to care. Inadequate access to healthcare was significantly higher among female children, children from low-income families, and children with ID. The access barriers among children with ASD-EP were more likely due to the interplay of multiple clinical and individual factors.
Episodic Memory in Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer’s Disease Dementia (ADD): Using the “Doors and People” Tool to Differentiate between Early aMCI—Late aMCI—Mild ADD Diagnostic Groups

Episodic memory is the type of memory that allows the recollection of personal experiences containing information on what has happened and, also, where and when it happened. Because of its sensitivity to neurodegenerative diseases and the aging of the brain, it is considered a hallmark of Alzheimer’s disease dementia (ADD). The objective of the present study was to examine episodic memory in amnestic mild cognitive impairment (aMCI) and ADD. Patients with the diagnosis of early aMCI, late aMCI, and mild ADD were evaluated using the Doors and People tool which consists of four subtests examining different aspects of episodic memory. The statistical analysis with receiver operating characteristic curves (ROC) showed the discriminant potential and the cutoffs of every subtest. Overall, the evaluation of episodic memory with the Doors and People tool can discriminate with great sensitivity between the different groups of people with AD and, especially, early aMCI, late aMCI, and mild ADD patients.
Awareness on Learning Delivery Modalities (LDM) and Readiness of Pre-Service Teachers in Remote Teaching Internship (RTI)

The widespread adoption of various education delivery modes during pandemic has created enormous change particularly, in terms of learning delivery modalities and teaching internship. This descriptive comparative and correlational study aimed to determine the level of awareness on learning delivery modalities (LDM) and readiness of pre-service teachers in remote teaching internship (RTI). The participants were 90 female and 28 male fourth year students from the Laguna State Polytechnic University-Los Baños Campus, Philippines’ College of Teacher Education (CTE). A validated research-based online questionnaire with Cronbach a ≥ 0.70 was utilized to gather the required data and information. Frequency counts and percentage were used to describe the pre-service teachers’ profile, while the level of awareness and readiness was determined by weighted mean. The significant differences were tested using t-test and F-test while Pearson Product-Moment Coefficient of Correlation with Kendal’s tau and Spearman rho were employed to test the significant relationship. The study found out that the pre-service teachers have moderate awareness of LDM with the calculated mean of 4.25 and found ready to conduct RTI with a mean of 4.16. The study failed to reject the hypotheses that there is no significant difference in the pre-service teachers’ level of awareness on LDM and readiness in RTI when grouped according to age, sex, and course. However, a P-value of 0.001 showed a significant relationship between their level of awareness on LDM and readiness in RTI, hence the hypothesis stating otherwise was rejected. Keywords: learning delivery modalities, remote teaching internship, awareness, readiness, pre-service teacher
Effects of Intrinsic and Extrinsic Motivational Factors on Employee Participation in Internal Crowdsourcing Initiatives in China

The concept of crowdsourcing, categorized into internal and external crowdsourcing, emerged relatively recently. Internal crowdsourcing gained increasing popularity in Chinese organizations. Based on the self-determination theory (SDT), this study advances the theoretical understanding of the effects of employee motivation antecedents (the three basic psychological needs: autonomy, competence, and relatedness) on participation effort in internal crowdsourcing activities. Through an online survey, 435 employees in information technology organizations in southern China completed the questionnaires which used for statistical analysis and hypotheses testing. It was found that the three basic psychological needs significantly positively impacted employees’ intrinsic motivation, with autonomy having the most significant effect. Furthermore, only the needs for autonomy and competence were significantly positively associated with extrinsic motivation. A positive relation was observed between intrinsic motivation and employee participation effort in internal crowdsourcing. Although no direct relationship was revealed between extrinsic motivation and employee participation effort, an indirect effect of extrinsic motivation on employee participation via intrinsic motivation was observed, which aligned with one of the main concepts of SDT, the internalization process of extrinsic to intrinsic motivation. Accordingly, the SDT model is applicable to information technology organizations in China based on the findings of this study.
True Multi-Objective Optimal Power Flow in a Deregulated Environment Using Intelligent Technique

in this paper, a Multi-Objective Particle Swarm optimization (MOPSO) technique is proposed for solving the Optimal Power Flow (OPF) problem in a deregulated environment. The OPF problem is formulated as a nonlinear constrained multiobjective optimization problem where the fuel cost and wheeling cost are to be optimized simultaneously. MVA-km method is used to calculate the wheeling cost in the system. The proposed approach handles the problem as a true multiobjective optimization problem. The results demonstrate the capabilities of the proposed approach to generate true and well-distributed Pareto-optimal solutions of the multiobjective OPF problem in one single run. In addition, the effectiveness of the proposed approach and its potential to solve the multiobjective OPF problem are confirmed. IEEE 30 bus system is considered to demonstrate the suitability of this algorithm.
Dynamics of pH, Ferrum and Mangan, and Phosphorus on Newly Opened Paddy Soil having High Soil Organic Matter on Rice Growth

Research had been carried out at the Research and Soil Testing Laboratory and Greenhouse of Soil Research Institute, Bogor using newly opened paddy soil from Pesisir Selatan districts, West Sumatra (one year old). Total treatments tested were 12 which were combination of farmer rate, NPK recommendation (½×; ¾×; 1½×), straw compost (½×; ¾×; 1½×), and dolomite. The trial was conducted using a completely randomized design with three replications. This research had been prepared in two units, one unit for observing plant response to nutrient management and another unit for incubation trial with the same treatment placed in the greenhouse. Rice cultivar used was IR-42 in accordance to the preferred varieties of local farmers. The sampling method for measuring the solubility of Fe2+ and Mn2+, as well as the availability of PO43- was by centrifuge 50 g mud samples from the incubation pots then separated clear extract using filter paper. The observation results on dynamics of pH, Fe2+, Mn2+ and PO4-3 mainly occured in 1 to 14 days after submerging (incubation). After 14 days soil reaction had reached thermodynamic sequence of oxidation-reduction processes, the PO43- more available and pH of the soil reached the peak. The optimum dose of NPK fertilizer obtained 0.875 NPK or equal to 175 kg of urea, 87.5 kg of SP-36 and 87.5 kg KCl ha-1. The highest number of hills achieved from straw compost treatment 1½ organic matter (OM) or 3 tons with an increase of 20%. Application of ameliorant dolomite increased the number of tillers about 2-3%, but insignificantly different with no dolomite treatment.
Optimal Design of a Novel Single-Phase 8-Slot 8-Pole Tubular Electromagnetic Shock Absorber to Harvest Energy

Based on the dimensions and thresholds of power and power density of a commercial shock absorber in the Korando car (an SUV branch), a single-phase 8-slot 8-pole tubular permanent magnet (PM) machine was designed and fabricated. The main focus of this paper is on the increase of output power in a given space and reduction of the volume. This is successfully solved using a novel structure for PM and considering a number of slot–pole combinations. Furthermore, a multiobjective optimization is performed to find the tradeoff between various objectives. The experimental results reveal that the proposed machine can possibly regenerate a maximum of 339.95 W and an average of 96.67 W in terms of its output power. Considering the active volume, which includes PM, iron core, pure copper, and an electromagnetic air gap, the estimated maximum and average power density are 0.311 and 0.087 W/cm3, respectively. Despite these satisfactory results, one of the major drawbacks to exploiting this machine is its high electromagnetic force, which causes negative effects on safety and driving comfort. With the aim to commercialize the proposed device, further work will be concentrated on the reduction of electromagnetic force and on performance of the road tests.
The Prevalence of Multimorbidity among Foreign-born Adults in the United States.

Objective We examined multimorbidity among foreign-born adults in the United States. This population may be particularly affected by chronic conditions and limited health care access. Design Longitudinal cohort. Setting United States. Participants Foreign-born adults at the point of legal permanent residency. Main Outcome Measures Multimorbidity defined as two or more of eight chronic conditions (hypertension, diabetes, obesity, arthritis, stroke, cancer, chronic lung disease, and heart problems). Methods We estimated the prevalence of multimorbidity and patterns over time. Data are from the New Immigrant Survey (NIS), a nationally representative study of adult immigrants at green card status in 2003 (N=8,174) and reinterview in 2008. Results The prevalence of multimorbidity was 6% in 2003, and 12% in 2008. The most common condition dyad at both time points was hypertension-obesity; the largest increase over time was in combinations that included hypertension, diabetes, and obesity. The odds of having multimorbidity compared to no chronic conditions were higher among older immigrants and those who had seen a doctor in the past year. The odds of gaining one chronic condition over a 5-year period increased with age; 45-65 years: OR 2.8[CI 2.3,3.5]; aged ≥65 years: OR 3.2 CI[2.2,4.7]. Conclusions The prevalence of multimorbidity among immigrants was lower than the prevalence in the overall US population of the same age, consistent with studies showing an immigrant health advantage.
Mathematical tools for making sense of a global pandemic

ABSTRACT The COVID-19 pandemic revealed that many countries have failed to provide the general population with the cognitive tools to thoroughly understand and cope with a global health crisis. While scientists and leaders worldwide have struggled to discover ways to contain the spread of the virus, this difficult task has become overwhelming due to the limited ability of many citizens to grasp the urgency of the situation. Although in today’s digitized world we have endless access to data and more ways to represent information and statistics than ever before, numerous incidents have demonstrated that the frequent misapprehension of data can cause confusion rather than clarity. This opinion paper examines how issues such as the misunderstanding of large quantities, fractions, probabilities, and mathematical modeling may be affecting the way people view the current pandemic. Finally, we also discuss how numeracy can act as a protective factor against motivated reasoning, which often affects how we consume information related to the pandemic.
Screening of Patient Impairments in an Outpatient Clinic for Suspected Rare Diseases—A Cross-Sectional Study

Background: Most rare diseases are chronic conditions with variable impairment of functionality, which can result in a need for rehabilitation. To our knowledge, there are no systematic studies on the rehabilitation needs of patients in centres for rare diseases in the literature. Our hypothesis is that participation of these patients is so limited that there is an increased need for rehabilitation. For this reason, a survey on the need for rehabilitation was carried out in all patients presenting to the centre for rare diseases, in order to assess the need for rehabilitative measures to counteract disturbances in activity and participation. Methods: A cross-sectional study was performed to collect data using a written questionnaire from December 2020 to June 2021, including patients presenting personally in the center for rare diseases. Results: Nearly 70% of the participants assessed their own ability to work as critical. Of those surveyed, n = 30 (44.9%) had PDI total ≥ 33 points and, thus, a clear pain-related impairment. Conclusion: The results show functional restrictions in the areas of mental well-being and activity. As expected, the health-related quality of life is reduced as compared to healthy people. Almost half of the participants reported significant pain-related impairments, however, only 9% of all respondents stated that they had received appropriate pain therapy. The results show the need for rehabilitation-specific skills in the care and counseling of patients with rare diseases.
Cumprimento da terapia com antidiabéticos orais em usuários da atenção primária

This transversal study aimed to evaluate compliance with pharmacological therapy among users of oral antidiabetic drugs. The research involved 437 diabetic patients of both sexes between 18-92 years of age from12 healthcare centers located in Fortaleza, Ceara, Brazil, between March and June of 2009. In order to evaluate their adhesion to oral antidiabetic medication, both Batalla's Test and the Treatment Adherence and Measurement Test were applied in households. Tablets were also counted. It was established that 74.6%, 86.3% and 71.2% were considered non-compliers according to the tests applied, respectively. Among the subjects not complying with their treatment via oral antidiabetics, 95% have missed diabetes therapeutic program appointments (p=0.000) and 76% maintain blood glucose levels above recommended values (p=0.013). It is possible that the core of the problem is in the professional-client relationship and in health education. Therefore, the revival of the foundations of health promotion need to permeate the actions of professionals involved in diabetic patient care. DESCRIPTORS: Patient compliance. Diabetes Mellitus type 2. Hypoglycemic agents.
KRAS G12C-Mutant Non-Small-Cell Lung Adenocarcinoma: First Documented Report in the Arabian Gulf

We report the first documented case series of two lung adenocarcinoma patients demonstrating Kirsten rat sarcoma viral oncogene homolog (KRAS) G12C mutations by reverse transcription-polymerase chain reaction techniques from Saudi Arabia. Both patients were males aged 64 and 76 years. The first had a heavy smoking history, while the second did not report any history of smoking. The tumor subtype was identified to be non-mucinous lung adenocarcinoma in both cases. The younger patient presented with generalized lymphadenopathy and a right-sided lung mass lesion, while the older patient exhibited stage III-A left lung adenocarcinoma that required rapid response. An initial examination of the first case showed a right-sided mediastinal shift, bilateral neck lymphadenopathy, and poorly differentiated neoplasm from a right supraclavicular core biopsy, leading to treatment with palliatives along with regular checkups. The second case was afebrile after being confirmed to be vitally stable and laboratory testing (Neutr 100). Further studies, specifically on large numbers of patients from the Arabian Gulf, are needed to confirm significant differences between the national and international populations. Additionally, future studies should investigate more differences in the differentiation of KRAS-mutant lung adenocarcinoma between patients from the Arabian Gulf and others.
Magnetically-coupled Current Sensor Using An Integrated Coil And A Cmos Split-drain Transistor

An integrated current sensing circuit intended for Smart-Power and embedded applications featuring galvanic isolation is implemented. It is based on magnetic detection using the CMOS compatible SplitDrain transistor (MAGFET) that provides a very linear output current versus magnetic field. The current to be sensed flows through an integrated coil placed atop the split-drain transistor and produces a relatively strong magnetic coupling enough to cause a detectable transistor unbalance current. An integrated sensor built in 0. 35μm CMOS technology presented an output conversion factor of 1500nA/A and a minimum detectable magnetic field around 1μT within 1Hz bandwidth in thermal range for 100μA transistor bias current. 1