Miracle-dz/UniFAR-FTUs huggingface dataset:
Systems Biology and Cytokines Potential Role in Lung Cancer Immunotherapy Targeting Autophagic Axis

Lung cancer accounts for the highest number of deaths among men and women worldwide. Although extensive therapies, either alone or in conjunction with some specific drugs, continue to be the principal regimen for evolving lung cancer, significant improvements are still needed to understand the inherent biology behind progressive inflammation and its detection. Unfortunately, despite every advancement in its treatment, lung cancer patients display different growth mechanisms and continue to die at significant rates. Autophagy, which is a physiological defense mechanism, serves to meet the energy demands of nutrient-deprived cancer cells and sustain the tumor cells under stressed conditions. In contrast, autophagy is believed to play a dual role during different stages of tumorigenesis. During early stages, it acts as a tumor suppressor, degrading oncogenic proteins; however, during later stages, autophagy supports tumor cell survival by minimizing stress in the tumor microenvironment. The pivotal role of the IL6-IL17-IL23 signaling axis has been observed to trigger autophagic events in lung cancer patients. Since the obvious roles of autophagy are a result of different immune signaling cascades, systems biology can be an effective tool to understand these interconnections and enhance cancer treatment and immunotherapy. In this review, we focus on how systems biology can be exploited to target autophagic processes that resolve inflammatory responses and contribute to better treatment in carcinogenesis.
Variability in Stigma Severity During the COVID-19 Pandemic

Objective The aim of this study was to investigate change in the stigma that emerged during the COVID-19 pandemic over time and the factors responsible for the change. Methods Individuals with COVID-19 who presented to Ankara Medicalpark and VM Medicalpark Hospitals' Internal Diseases and Chest Diseases polyclinic between May 2021 and April 2022 were examined. The volunteers were divided into two groups: those who had COVID-19 within the first six months of the pandemic (group 1) and those who had it in the second six months (group 2). The questionnaire assessing stigma consisted of 29 propositions that participants could mark whether they agreed with them or not. Results The median age of the volunteers was 38 years. Eighty-eight (69.3%) had the disease in the first six months of the pandemic and 39 (30.7%) in the second six months. Moreover, 76.1% of the participants in the first group and 94.9% of those in the second group did not agree with the statement "I thought COVID-19 was a punishment for me" (p=0.011). Further, 56.8% of the participants in the first group and 97.4% of those in the second group stated that they did not agree with the statement "Employers may terminate the employment of employees who they find out have contracted COVID-19" (p<0.001). 80.7% of the participants in the first group and 38.5% of those in the second group agreed with the statement "There was social discrimination against people who caught COVID-19" (p<0.001). Conclusions At the beginning of the pandemic, the participants had concerns about losing their status and jobs, but this anxiety decreased over time. Stigma in the first six months of the pandemic was greater than that in the second six months, and discrimination related to stigma decreased with recognition of the disease and the increase in experience.
Metallogeny of tin in central Thailand: A genetic concept

Tin mineralization in central Thailand is associated with granitic rocks of the Thai-Burmese border range (western group). Granitic intrusions east of Bangkok and near the Kampuchea border (eastern group) have no tin. Fractional crystallization is the fundamental petrogenetic process that controls the evolution of both groups of granites. The tin-bearing alkali-feldspar aplogranites of the western group display an extreme degree of differentiation that has no petrological equivalent in the eastern group. These aplogranites are the product of a combination of magmatic fractionation (primary tin enrichment trend) modified by fluid interaction. The latter process is responsible for a secondary geochemical tin deficiency that is balanced by redistribution of tin in fracture systems—i.e., tin mineralization. The pattern of tin depletion in the aplogranites provides an indication of the tin potential in a given ore-forming system.
Role of complement in myasthenia gravis

Myasthenia gravis is a prototypic neuroimmune disorder with autoantibodies targeting the acetylcholine receptor complex at the neuromuscular junction. Patients present with mainly ocular muscle weakness and tend to have a generalized muscle weakness later in the clinical course. The weakness can be severe and fatal when bulbar muscles are heavily involved. Acetylcholine receptor antibodies are present in the majority of patients and are of IgG1 and IgG3 subtypes which can activate the complement system. The complement involvement plays a major role in the neuromuscular junction damage and the supporting evidence in the literature is described in this article. Complement therapies were initially studied and approved for paroxysmal nocturnal hemoglobinuria and in the past decade, those have also been studied in myasthenia gravis. The currently available randomized control trial and real-world data on the efficacy and safety of the approved and investigational complement therapies are summarized in this review.
Reliability Analysis of Rock Wedges

The stability analyses of tetrahedral wedges in rock slopes are commonly conducted using the versatile sequential vectorial operations or stereographic projection methods. This paper presents an alternative approach using closed-form equations, for cases where the upper ground surface dips in the same direction as the slope face. The equations allow determination of kinematic admissibility, the mode of sliding (whether along two planes or a single plane), and the corresponding factor of safety. Since the factor of safety does not reflect the uncertainty of parameters, the Hasofer-Lind second moment reliability index is explored. Useful insights are obtained based on the perspective of an ellipsoid expanding in the original space of the random variables. The proposed perspective also suggests a practical method of computing the reliability index using the \ISolver\N tool available in a spreadsheet software. First-order probability bounds based on reliability indices of a tetrahedral wedge are in good agreement with the results of Monte Carlo simulation. The need to account for multiple failure modes and to consider all surfaces bounding the failure domain is demonstrated.
Performance of Tomato Cultivars Under Greenhouse Conditions in Northern India

Abstract Greenhouse cultivation of vegetables has only recently begun to be used in India. There is no information yet available on the suitability of tomato (Lycopersicon esculentum Mill.) cultivars that can be used for this type of cultivation. The imported tomato cvs. R-144 (Daniela), FA-179, FA-180, and FA-574, and the local cvs. DT-2 and DT-7 were evaluated under greenhouse conditions in northern India from September to June for the 2000-2001 and 2001-2002 growing seasons for yield and quality traits. The cv. R-144 (Daniela) had the best yield (21.9 and 20.4 Mg/1000 m2) and number of fruit/truss (5.6 and 5.4) during both years. The cv. FA-574 had the heaviest fruit (145.0 and 140.0 g). During 2001-2002, ‘DT-7’ had the fewest fruit/truss (3.2), average fruit weight (70.0 g), and the lowest fruit yield (8.3 Mg/1000 m2). ‘R-144’ (‘Daniela’) had the highest percentage of first quality fruit, 89.0 and 91.3%, with the lowest incidence of blossom end rot, 1.0 and 0.5%, respectively, for the two years. The greatest percentage of second quality fruit was from ‘DT-2’ (79.6%) during 2000-2001 and ‘DT-7’ (84.6%) during 2001-2002. Blossom end rot incidence was highest in ‘DT-7’ (14.2%) during 2000-2001 followed by ‘DT-2’ (11.0%). Overall performance of ‘R-144’ (‘Daniela’) was judged best for greenhouse commercial production under local conditions.
Striking the Balance: The Priority Ranking of Flexible Work Arrangements in Freight Forwarding Companies

The Flexible Work Arrangements (FWA) is increasing its prominence in today’s business world. Companies are increasingly adopting flexibility to improve employee happiness and overall operational efficiency as the landscape of work patterns evolves. There is a growing research need to address the relative importance of different FWA according to specific business fields of the companies. This study aims to contribute to the field of organizational management by systematically prioritizing and ranking various FWA in the context of Turkish freight forwarding companies using the Analytic Hierarchy Process (AHP) methodology. The literature mainly suggests available FWA and their individual contributions to employee satisfactions. However, there is a research gap to identify the most relevant methods that match the specific needs of the sea freight forwarding sector. This study tries to construct a complete hierarchy of flexible work arrangements by meticulously using the AHP framework and including the viewpoints of both academics and Human Resources (HR) officials. This study seeks to establish a comprehensive hierarchy of flexible work arrangements, taking into account practices such as remote work, flextime, flexplace, and leave control, among others, through a meticulous application of the AHP framework. The findings of this study are expected to provide practical insights, assisting freight forwarding firms in making educated decisions on the implementation and priority of flexible work practices and promoting a harmonious and productive work environment.
An assessment of Geosat wave height and wind speed measurements

An assessment is made of the significant wave height and wind speed measurements obtained by the Geosat radar altimeter. In comparison with buoy data, it is found that Geosat underestimated the significant wave height by 13% throughout the range of measurements. An attempt to compare the wave measurements made by Seasat and Geosat reveals problems with both data sets. For the Geosat wind speed measurements, it is found that the smoothed-Brown algorithm, usually employed to convert backscattered power to wind speed, does not give good results in comparison with buoy measurements. A simple linear relationship between backscattered power and wind speed is derived, which is in close agreement with the algorithm recently proposed by Witter and Chelton for wind speeds above 3 m s−1. The implications of these results for deriving wind and wave climatologies from altimeter data are discussed.
Suppression of spring rain by surface greening over North China Plain

Surface greenness and rainfall in spring have changed from the 1980s to 1990s over the North China Plain (NCP). The greenness changes are characterized by large increase in north and little in south with an obvious greening zone from the centre of the NCP to the northeast. The rainfall change has a similar spatial pattern with reversed sign. The correlation between changes in greenness and rainfall is significant and the correlation (r = −0.71, p < 0.001) is highest for light rainfall. The number of light rainfall days decreased by only ∼10% at the stations where the Normalized Differences Vegetation Index (NDVI) did not change, whereas it decreased by up to ∼30% at the stations where NDVI increased by 20%. Further analyses found that surface greening increased evaporation wetting the atmosphere and, meanwhile, reduced sensible heat flux to cooling surface air. The cooling surface promotes the air stability and thus suppresses the occurrence of rainfall. This finding supports that surface cooling effects from greening play a more dominant role on occurrence of spring rainfall than the wetting effect in the NCP.
Efficacy of a Neuromuscular Warm-up Program in Reducing the Risk of School Sports Injury among Chinese Children: A Cluster Randomized Controlled Trial

Background: Children who participate in sports have reduced cardiovascular risk, obesity, and type 2 diabetes. However, sports participation also comes with an inherent risk of sports-related injuries. Purpose: To examine the efficacy of a school-based neuromuscular warm-up program (NWP) in reducing the risk of school sports injury (SSI) in children and the impact of different levels of compliance on the effectiveness of the program. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 421 students from grades 4 to 6 at a single school (age range, 9-14 years) were randomized by grade to an intervention group and a control group. The intervention group participated in a 13-week simplified (8-minute) NWP designed to reduce SSI risk. The control group participated in a standard warm-up of the same length and duration. Exposure, compliance, and injury data were collected via a weekly form. The primary injury outcome was all SSIs. Secondary outcomes included injuries from physical education (PE) and non-PE class, upper and lower extremity injuries, other location injuries, and time-loss injuries. A Poisson regression model using an intent-to-treat analysis was performed to estimate the incidence rate ratio (IRR) for all injuries in the intervention group compared with the control group. To examine the influence of level of compliance, we divided the intervention group into low compliance (participation 1-2 times/wk) and high compliance (participation >2 times/wk) then compared the difference on injury rates (IRs) between these groups and the control group. Results: There were significant differences between the intervention and control groups regarding all SSIs (IRR, 0.47; 95% CI, 0.23-0.96; P = .038), PE class injuries (IRR, 0.37; 95% CI, 0.14-0.99; P = .048), and other location injuries (IRR, 0.20; 95% CI, 0.05-0.82; P = .025). The compliance analysis revealed that although the low-compliance group was able to reduce the risk of SSIs (IR, 4.43; 95% CI, 2.49-6.37) compared with the control group (IR, 7.60; 95% CI, 5.61-9.59), the high-compliance group produced a better effect in reducing the SSI risk (IR, 1.80; 95% CI, 0.04-3.56). Conclusion: The simplified NWP used in this study was efficacious in the reduction of SSIs in children. Registration: ChiCTR2100043875 (Chinese Clinical Trial Registry; http://www.chictr.org.cn).
A retrospective study of SARS-CoV-2 seroprevalence in dogs and cats in the Community of Madrid, Spain

To date, susceptibility to SARS-CoV-2 infection in domestic animals including cats and dogs has been described. However, it is important to carry out passive surveillance of these animals to be aware of any changes in the outcomes of the disease in these species that may occur. In this study, we have performed a retrospective study in which we analyzed sera (n = 1,640) from random animals: dogs (n = 1,381) and cats (n = 259) belonging to both homes (n = 1,533) and animal protection centers (n = 107) in the Community of Madrid, Spain. Neutralizing antibodies were evaluated between November 2021 and May 2022 using a surrogate ELISA kit to determine the seroprevalence. Based on the results obtained, a few animals (both cats and dogs) presented neutralizing antibodies to SARS-CoV-2 (2.3%), all of them from private owners. However, the seroprevalence in cats (4.6%) resulted to be almost twice as much as in dogs (1.9%) which reinforces that cats’ susceptibility to the infection seems higher than in the case of dogs, maybe due to the lower ACE2 expression of the dogs in the respiratory tract. These findings also confirm that the probability of infection is considerably higher in domestic animals in close contact with infected owners, compared to animals living in animal shelters whose contact with humans is markedly lower.
TMAH Pretreatment to Minimize Ohmic Contact Resistance in InAlN/GaN-on-Si RF HEMTs

We report a novel tetramethylammonium hydroxide (TMAH) pretreatment to minimize the contact resistance <inline-formula> <tex-math notation="LaTeX">$\left(R_{C}\right)$ </tex-math></inline-formula> using Ti-based Ohmic contacts to InAIN/GaN-on-Si RF HEMTs. The TMAH treatment is shown to etch the dislocation sites on the surface, which act as a medium for Ti diffusion into GaN during annealing. This enhances the TiN contact inclusion formation inside the GaN channel layer and results in an <inline-formula> <tex-math notation="LaTeX">$R_{C}$ </tex-math></inline-formula> of <inline-formula> <tex-math notation="LaTeX">$0.23 \pm 0.01 \Omega-\mathrm{mm}$ </tex-math></inline-formula>, which is threefold lower compared to a sample without TMAH treatment. The impact of <inline-formula> <tex-math notation="LaTeX">$R_{C}$ </tex-math></inline-formula> on RF performance is studied using sub-quarter micron HEMTs. For the sample with TMAH pretreatment, a high <inline-formula> <tex-math notation="LaTeX">$f_{T}$ </tex-math></inline-formula> of 95 GHz and a <inline-formula> <tex-math notation="LaTeX">$f_{T}-L_{G}$ </tex-math></inline-formula> product of <inline-formula> <tex-math notation="LaTeX">$19 \mathrm{GHz}-\mu \mathrm{m}$ </tex-math></inline-formula> are achieved in a device with 200 nm gate and 900 nm source-to-drain separation.
Climate Sensitivity to Changes in Ocean Heat Transport

AbstractUsing an atmospheric general circulation model coupled to a slab ocean, the effects of ocean heat transport (OHT) on climate are studied by prescribing OHT from 0 to 2 times the present-day values. In agreement with previous studies, an increase in OHT from zero to present-day conditions warms the climate by decreasing the albedo due to reduced sea ice extent and marine stratus cloud cover and by increasing the greenhouse effect through a moistening of the atmosphere. However, when the OHT is further increased, the solution becomes highly dependent on a positive radiative feedback between tropical low clouds and sea surface temperature. The strength of the low cloud–SST feedback combined with the model design may produce solutions that are globally colder than in the control run, mainly due to an unrealistically strong equatorial cooling. Excluding those cases, results indicate that the climate warms only if the OHT increase does not exceed more than 10% of the present-day value in the case of a s.
Extensional tectonics in the Gorringe Bank rocks, Eastern Atlantic ocean: evidence of an oceanic ultra‐slow mantellic accreting centre

The Gorringe Bank corresponds to an upper mantle peridotite ridge enclosing a 500‐m thick/ 50‐km long laccolith‐like body of gabbro, locally cut and poorly covered by tholeiitic rocks. Strain and kinematic analysis of orientated gabbros and peridotites sampled during the GORRINGE diving cruise (1996) provides new kinematic constraints on extensional high‐temperature deformation recorded at deep levels during stretching, near an accreting centre axis of a mantle‐dominant oceanic lithosphere. It is argued that the Gorringe Bank lithosphere formed at an oceanic ultra‐slow, N010°–020°‐trending accreting centre, mostly by passive tectonic denudation of the mantle, without any synchronous large magmatism. This peculiar lithosphere may be representative of the Iberia oceanic domain located between the continent and the J anomaly ridge, which likely marks the beginning of true spreading at an oceanic spreading ridge.
Biogázüzemi fermentlé és Phylazonit MC baktériumtrágya hatása a silókukorica zöldtömegére és a talaj biológiai aktivitására

Munkankban biogazuzemi fermentle es Phylazonit MC bakteriumtragya hatasat vizsgaltuk masodvetesű silokukorica ( Zea mays L. ’Coralba’) tesztnoveny zoldtomeg hozamara es a talaj biologiai aktivitasanak valtozasara__
Cesbronite, a new copper tellurite from Moctezuma, Sonora

Summary Cesbronite occurs at the Bambollita mine, near Moctezuma, Sonora, with a variety of other tellurites. The colour is ‘green beetle’ (R.H.S. 135-B) with a pale streak. H 3; Dmeas 4·45±0·2. Crystals are orthorhombic 2 mmm with a 8·624 Å, b 11·878, c 5·872 (all ± 0·016 Å); space group Pbcn. For Z = 2 the calculated density is 4·455 g/cm3. The strongest powder lines are 5·934 (100), 3·490 (92), 4·889 (71), 2·358 (70), 2·379 (38), 1·592 (34), 2·156 (28), and 1·698 (27). Electron-probe analysis gave: CuO 50·3 %, 50·3, 49·8, 49·4; TeO2 39·3 %, 39·2, 38·6, 38·6. Water determined gravimetrically 11·0 %. This gives Cu5(TeO3)2(OH)6.2H2O. Cesbronite is pleochroic with absorption γ ≈ β ≫ α. Optically positive with 2V γ calc. 72°; α 1·880 ‖[100], β 1·928 ‖[001], γ 2·029 ‖[010].
STABLE-ISOTOPE INVESTIGATIONS OF SEDIMENTS FROM THE DSDP III CRUISE TO SOUTH ATLANTIC

Ten samples of sediments and sedimentary rocks collected during the DSDP (Deep Sea Drilling Project)'s Leg III cruise to South Atlantic were analyzed for oxygen and carbon isotope abundances. These samples include dolomitic chert, Braarudosphaera chalk, stiff pelagic chalk ooze, biosparitic coquina and a white marble near a basalt contact. Although the analyzed values of the oxygen and carbon isotope ratios do not in every instance give a unique answer, they do provide clues and place limitations on speculations regarding the genesis and diagenesis of the samples in question. The significant conclusions are: 1 The generation of the Oligocene Braarudosphaera chalk in the South Atlantic was probably related to the upwelling of very cold Antarctic waters. 2 The biosparitic Cretaceous coquina on the Rio Grande Rise has been cemented under submarine conditions. 3 The marble between the basalt and overlying ooze is not contact metamorphic, but has been crystallized at a normal deep-marine temperature of about 4.5 °C.
“Technology earns us respect from your able-world”: Disabled students’ perceived outcome of digital technology use in higher education

Disability has yet to be demystified in many aspects. It is ridden with social sigma and lack of understanding. Nevertheless, perspectives surrounding disability can change greatly, and this would help ensure equitable human rights for all. Other changes wrought by recent technological transformation have not only made our life easier but also broadened the inequality and opportunity gap to some context. Considering such matters affecting access and equity in education, and with the qualitative methodology at the core so as to capture and analyse detailed data in depth and with sufficient trustworthiness, this paper aims explored the consequences of digital technology utilization of students with disability in Higher Education (HE) in Bangladesh. The findings depicted how technology uses helped students with disability to empower themselves and to become mostly self-dependent. Teacher’s World: Journal of Education and Research, Vol. 48(2), Dec 2022, p.102-111