Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunophenotypic Landscape and Prognosis-Related mRNA Signature in Diffuse Large B Cell Lymphoma

Diffuse large B cell lymphoma (DLBCL) exhibits a tightly complexity immune landscape. In this study, we intended to identify different immune phenotype and to examine the immune related mRNA signature for clinical characteristic, therapeutic responsiveness as well as risk stratification and survival prediction in DLBCL. We identified two immune infiltration subtypes of DLBCL patients based on 28 immune cell types. GSEA analysis uncovered the concordant classification of two robust significant subtypes of DLBCL. Considering the convenient application of the immune infiltration subtypes for prognostic prediction, we developed a risk score based on the differentially expressed genes between the Immunity-H and Immunity-L groups. By a least absolute shrinkage and selection operator (LASSO)-Cox regression model, a sixteen-gene risk signature, comprising ANTXR1, CD3D, TIMP1, FPR3, NID2, CTLA4, LPAR6, GPR183, LYZ, PTGDS, ITK, FBN1, FRMD6, PLAU, MICAL2, C1S, was established. The comprehensive results showed that the high-risk group was correlated with lower immune infiltration, more aggressive phenotypes, lower overall survival and more sensitive to lenalidomide. In contrast, a low-risk group score was associated with higher immune infiltration, less aggressive phenotypes, better overall survival and more likely to benefit from PD-1/PD-L1 inhibitors. Finally, a nomogram comprised of the risk score and IPI score was verified to more accurately predict the overall survival of DLBCL than traditional clinical prediction models. Altogether, our data demonstrate the heterogeneity of immune patterns within DLBCL and deepen our molecular understanding of this tumor entity.
Is Mexico beyond mestizaje? Blackness, race mixture, and discrimination

ABSTRACT In the 1980s and 1990s, a wave of multiculturalism swept across Latin America, following long-standing ideologies of mestizaje which glorified the region’s biological and cultural mixture and asserted that such mixture precluded the existence of racism. A decade or so later, countries in the region enacted another set of reforms focused on combatting ethnoracial discrimination and inequality. Whereas many view these changes as indicating the downfall of mestizaje ideologies, others argue that they may not be as distinct from mestizaje as it may appear. I reflect on this question in the context of Mexico, drawing on data from recent government and private surveys to assess the current state of Mexican national ideology, both at the national level and in a local site of blackness. I provide novel findings about the kinds and prevalence of various forms of black identification, the extent of black-indigenous boundary crossing, and the strength of attitudes about mestizaje and racism. Ultimately, I show how ideologies and discourses associated with mestizaje, multiculturalism, and racial equality are absorbed at the popular level in ways that suggest that at least some parts of the ideology of mestizaje are enduring or evolving to accommodate these new ethnoracial projects.
Verbundverhalten umwickelter CFK‐Stäbe in Beton – Kurzzeituntersuchung der Verbundeigenschaften mittels Pull‐out‐Tests

Der Einsatz und die Verfügbarkeit von Bewehrung aus Carbonfaserverbundkunststoff (CFK) steigen stetig, weshalb ein umfangreiches Verständnis der Verbundeigenschaften essenziell ist. Die vorliegende Publikation gibt einen Überblick über unterschiedliche Ausführungsformen von CFK‐Stäben sowie über den Einfluss von ausgewählten Parametern auf das Verbundverhalten. Der Fokus wurde auf Stäbe mit straffer Umwickelung aus CFK‐Fasersträngen gelegt und die Konkurrenzfähigkeit im Vergleich zu anderen, beispielsweise subtraktiv bearbeiteten, eingefrästen Stäben wird aufgezeigt. In 84 Ausziehversuchen wurde das Verbundverhalten von umwickelten CFK‐Stäben in vier Betonarten getestet. Bei den untersuchten Stäben wurden dabei die Wendelbreite und ‐dicke, die Wendelsteigung, der Wendelabstand und der Stabdurchmesser variiert. Die Versuchsergebnisse werden in Verbundspannungs‐Schlupfdiagrammen präsentiert, verglichen und abschließend diskutiert.
Flow and Drop Transport Along Liquid-Infused Surfaces

Liquid-infused surfaces (LISs) are composite solid–liquid surfaces with remarkable features such as liquid repellency, self-healing, and the suppression of fouling. This review focuses on the fluid mechanics on LISs, that is, the interaction of surfaces with a flow field and the behavior of drops on such surfaces. LISs can be characterized by an effective slip length that is closely related to their drag reduction property, which makes them suitable for several applications, especially for turbulent flows. Drag reduction, however, is compromised by failure mechanisms such as the drainage of lubricant from surface textures. The flow field can also sculpt the lubricant layer in a coupled self-organization process. For drops, the lubricant reduces drop pinning and increases drop mobility, but also results in a wetting ridge and the associated concept of an apparent contact angle. Design of LIS wettability and topography can induce low-friction drop motion, and drops can dynamically shape the lubricant ridges and film thickness. Expected final online publication date for the Annual Review of Fluid Mechanics, Volume 54 is January 2022. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Effective use of microbes in waste soil stabilisation considering natural temperature variations

ABSTRACT Dredged soils are waste deposits left unutilised in huge quantities. In order to effectively utilise such weak deposits, proper improvement techniques need to be adopted. In this study, four different bacillus microbes namely Bacillus pasteurii, Bacillus megaterium, Bacillus sphaericus and Bacillus subtilis along with cementing solution at different molarities (0.5 and 1 CSM) have been incorporated into the soil at an optical density of 1.5 (108 cells/ml). Unconfined compressive strength (UCS) and permeability tests have been performed on the soil samples. The samples were provided treatment (48 h) and curing (7 and 14 days) in natural conditions. The UCS test results at 0.5 CSM and 7 days curing revealed a noticeable enhancement. Permeability reduced by one order at 14 days of curing and 1 CSM. Three different ranges of temperature depending upon natural climatic variations were designated for testing, and it was concluded that 18–23°C was the optimum temperature for all the treatment processes. This study puts forth the importance of green eco-friendly technology in improving dredged soils from wetland peripheries thus helping indirectly in restoring its balance. Scanning electron microscopy (SEM) along with energy dispersive spectroscopy (EDS) provided conclusive support to the experimental investigations.
Antibacterial Efficacy of Some Medicinal Plants on Multidrug Resistance Bacteria and Their Toxicity on Eukaryotic Cells

The aim of this study was to evaluate the in vitro antimicrobial activity of medicinal methanolic plant extracts against multidrug-resistant bacteria to determine the cytotoxicity of these extracts on eukaryotic cells, and to confirm their efficacy against Methicillin-Resistant Staphylococcus aureus (MRSA) in experimental animals. The effects of the methanol extract of sixty folk plants were investigated on; MRSA, Extended Spectrum Beta-Lactamase E. coli and MDR Pseudomonas aeruginosa by disc diffusion and MIC assay. Cytotoxicity was determined using MTT and hemolysis of human erythrocytes. Three plant extracts with the highest antimicrobial activities were tested using a challenge experiment on mice. Systemic infection was performed by intraperitoneal inoculation of (5 × 106 CFU/mL) of MRSA isolate. Then mice received 300 mg/kg body weight of the plant extracts daily for seven days. The efficacy of plant extracts was evaluated by general health, mortality rate, gross lesion, and histopathology study of inoculated mice. Only ten plants showed activities against different MDR bacteria with inhibitory zones ranging from (8 to 22 mm) in diameter. Of the ten medicinal plant extracts, Camellia sinensis and Aloysia citrodora showed the highest activities against MRSA and MSSA isolates, with MIC value ranging from 0.5 to 1.5 mg/ml, followed by Hibiscus sabdariffa, Thymus vulgaris, and Glycyrrhiza glabra. Furthermore, the extract of the effective plants showed low toxicity against Vero and fibroblasts cell lines, along with inhibitory activities to erythrocytes membrane disruption. The in vivo study demonstrated that Camellia sinensis showed significant activity against MRSA infections in mice. The results validate that these plants are effective and safe antibacterial agents against multidrug-resistance bacteria, and have the potential to be utilized as an alternative to antibiotics for the treatment of bacterial infections.
What is good is beautiful (and what isn’t, isn’t): How moral character affects perceived facial attractiveness

A well-documented “beauty-is-good” stereotype is expressed in the expectation that physically attractive people have more positive characteristics. Recent evidence also finds that unattractive faces are associated with negative character inferences. Is what is good (bad) also beautiful (ugly)? Whether this conflation of aesthetic and moral values is bidirectional is not known. This study tested the hypothesis that complementary “good-is-beautiful” and “bad-is-ugly” stereotypes bias aesthetic judgments. Using highly controlled face stimuli, this pre-registered study examined whether moral character influences perceptions of attractiveness for different ages and sexes of faces. Compared to faces paired with non-moral vignettes, those paired with prosocial vignettes were rated significantly more attractive, confident, and friendlier. The opposite pattern characterized faces paired with antisocial vignettes. A significant interaction between vignette type and the age of the face was detected for attractiveness. Moral transgressions affected attractiveness more negatively for younger than older faces. Sex-related differences were not detected. These results suggest information about moral character affects our judgments about facial attractiveness. Better people are considered more attractive. These findings suggest that beliefs about moral goodness and physical beauty influence each other bidirectionally.
Urinary concentrations and determinants of pyrethroid metabolites in pregnant women from non-rural areas of Yunnan, China.

INTRODUCTION AND OBJECTIVE The study assesses the levels of urinary pyrethroid pesticide (PYR) in women during early pregnancy. The factors associated with exposure are also determined. MATERIAL AND METHODS A total of 480 pregnant women from non-rural areas visiting hospital for prenatal examination during early pregnancy were enrolled. A self-designed, structured questionnaire was used to collect data on potential factors of PYR exposure. Urinary PYR metabolite levels were quantified using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). RESULTS The majority of urine samples (98.8%) contained one or more PYR metabolite, although only a few women self-reported pesticide exposure. Urinary 3-phenoxybenzoic acid (3PBA) levels were close to those reported in certain developed countries. However, the levels of 3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA) and 4-fluoro-3-phenoxybenzoic acid (4F3PBA) were higher than those reported in previous studies. Urinary PYR levels were positively associated with exposure to pesticides, consumption of bananas and oranges, the number of fruit types the women regularly ate, being multiparous, and cooked frequently. They were negatively associated with early pregnancy body mass index (BMI), unemployment, frequent intake of apples, and washing fruits and vegetables with soda or hot water. CONCLUSIONS Pregnant women in non-rural areas were extensively exposed to low levels of PYRs. Dietary intake may be the primary pathway of exposure. The presented findings highlight the importance of using appropriate methods to reduce pesticide residues in food.
Using DNDC and WHCNS_Veg to Optimize Management Strategies for Improving Potato Yield and Nitrogen Use Efficiency in Northwest China

Excessive nitrogen (N) application rate led to low N use efficiency and environmental risks in a potato (Solanum tuberosum L.) production system in northwest China. Process-based models are effective tools in agroecosystems that can be used to optimize integrated management practices for improving potato yield and N use efficiency. The objectives of this study were (1) to calibrate and evaluate the DeNitrification-DeComposition (DNDC) and soil Water Heat Carbon Nitrogen Simulator of Vegetable (WHCNS_Veg) models using the measurements of potato yield, above-ground biomass, N uptake, soil moisture and temperature, and soil inorganic N based on a field experiment in northwest China (2017–2020) and (2) to explore optimal management practices for improving yield and N use efficiency under long-term climate variability (1981–2020). Both models overall performed well in simulating potato tuber yield (normalized root mean square error (NRMSE) = 5.4–14.9%), above-ground biomass (NRMSE = 6.0–14.7%), N uptake (NRMSE = 18.1–25.6%), daily soil temperature (index of agreement (d) > 0.9 and Nash–Sutcliffe efficiency (EF) > 0.8), and acceptable in-soil moisture and inorganic N content (d > 0.6 and EF > ‒1) for N-applied treatments. However, the two models underestimated tuber yield and soil N content for no N fertilization treatment which was partially attributed to the underestimated soil N mineralization rate under N stress conditions. The sensitivity analysis showed that the greatest tuber yield and N use efficiency were achieved at the N rate of 150–180 kg ha−1 with 2–3 splits, fertilization depth of 15–25 cm, and planting date of 25 April to 10 May in both models. This study highlights the importance of integrated management strategies in obtaining high N use efficiency and crop yield in potato production systems.
Adherence to mobile‐app‐based dietary self‐monitoring—Impact on weight loss in adults

Greater dietary self‐monitoring adherence is associated with weight loss, however, the dietary self‐monitoring adherence criteria that predict weight loss are unknown. The criteria used to define adherence to dietary self‐monitoring in obesity treatment tend to vary, particularly in studies that include dietary self‐monitoring via mobile applications (apps). The objectives of this study were to (a) determine weight change outcomes related to app‐based dietary self‐monitoring and (b) determine the associations between the frequency, consistency, and completeness of dietary self‐monitoring and weight change.
Awareness level on the relevance of forensics in criminal investigation in Nigeria

The main aim of forensic science is to gather intelligence to enable the judge to credible and logical decisions in the court by means of scientific approach through evaluation of evidence for the administration of justice, and country around the world now considers forensic methodology as the gold standard for criminal investigation. Therefore, the present study examined the level of awareness on the relevance of forensics in criminal investigation in Nigeria. The design used in this study is the survey research design and the sample size of this study was a total of one hundred personnel of law enforcement and the judiciary. The study adopted descriptive statistics which involves the use of frequency and percentage. The result of the present study revealed that the participants were distributed socio-demographically as follows; there was an observable higher number of male participants (68%) relative to the female participants (32%), As per age distribution, a larger population of the participants were found to be > 40 years of age with 55%, and it was observed that age between 35-39 years ranked the least with 15%. On educational level, the result of the present study revealed that majority of the participants possesses a bachelor’s degree as the highest level of educational qualification with 75% from a pool of 100% of participants. The present study further examined responses on the relevance of forensics in criminal investigation, and the result revealed an inadequate level of awareness on the relevance of forensics in criminal investigation. Therefore, the study recommends that the Nigerian Police Force and the Judiciary should collaborate with Universities running programs on forensics for trainings.
“Education cannot cease”: the experiences of parents of primary age children (age 4-11) in Northern Ireland during school closures due to COVID-19

ABSTRACT This paper reports the research findings from an online survey of parents of primary-age pupils in Northern Ireland during the COVID-19 pandemic. The aims of the study were to explore how parents supported their child/ren’s home learning; to ascertain the communication, guidance and resources between home and school; and to learn from the experiences of parents to enable more effective practices to be established should similar circumstances arise in the future. The survey yielded 2,509 responses and highlighted the divergence of practices in relation to home-school communications across schools as well as the challenges experienced by parents, particularly those who had one or more children with special educational needs and/or those who had Free School Meal Entitlement. The study was guided by Epstein’s Framework of the Six Types of Involvement, most specifically the spheres of parenting, learning from home, communication, collaborating with the community and decision-making. Within Epstein’s framework, the challenges and tensions between family, school and work are explored. Recommendations are made that will be helpful to parents, schools, teacher-educators, policy-makers and researchers in informing the shape and delivery of education in Northern Ireland and internationally both during and following the challenge of the current COVID-19 pandemic and for similar situations that may arise in the future. The findings and conclusions are relevant not only to the Northern Ireland education context, but also make a valuable contribution to global dialogue on what this experience has revealed about inequities in education systems and how these should be addressed going forward.
The eco‐evolutionary dynamics of prior selfing rates promote coexistence without niche partitioning under conditions of reproductive interference

Pollinator‐mediated reproductive interference can occur when two or more plant species share the same pollinators. Recent studies have suggested that prior autonomous selfing mitigates reproductive interference, potentially facilitating coexistence even in the absence of pollination niche partitioning (i.e. the pre‐emptive selfing hypothesis). However, whether the evolution of prior selfing promotes coexistence, in the context of the eco‐evolutionary dynamics of population size, selfing rates and inbreeding depression, remains poorly understood. We constructed an individual‐based model to examine the conditions under which the evolution of prior selfing promotes coexistence in the context of mutual reproductive interference. In the model, two plant species compete by way of mutual reproductive interference, and both have the potential to evolve the capacity for prior autonomous selfing. We expected that purging of deleterious mutations might result in evolutionary rescue, assuming that the strength of inbreeding depression declines as the population selfing rate increases; this would enable inferior competitors to maintain population density through the evolution of prior selfing. Our simulation demonstrated that evolution of prior selfing may promote coexistence, whereas reproductive interference in the absence of such evolution results in competitive exclusion. We found that lower pollinator availability is likely to favour rapid evolutionary shifts to higher prior selfing rates, thereby neutralising the negative effects of reproductive interference in both species. When the strength of inbreeding depression decreased with an increase in the population‐level selfing rate, moderate pollinator availability resulted in long‐term coexistence in which relative abundance‐dependent selection on the prior selfing rate served to intermittently maintain the population density of the inferior competitor. Synthesis. We demonstrate that the evolution of prior selfing may increase population growth rates of inferior competitors and may consequently promote long‐term coexistence via an evolutionary rescue. This constitutes a novel mechanism explaining the co‐evolutionary coexistence of closely related plant species without niche partitioning, and is consistent with recent studies reporting that closely related species with mixed mating systems can co‐occur sympatrically, even under conditions of mutual reproductive interference.
The Problem of Overweight and Obesity - Does Geographical Location Matter?

The number of people with overweight and obesity issues has been increasing rapidly worldwide. This increase is related to many factors including physical activity, social background, economic development, cultural practices, etc. This study examined the body mass index (BMI) of 25,373 children, aged 6-12 years, from four Asian cities to assess children’s health status and the association of geographical location with BMI issues. BMI data were calculated and classified according to the WHO criteria. Differences in height, weight, and BMI were calculated for boys and girls from different cities. Cross-city analyses revealed significant differences: children from the cities in higher latitudes had the highest chances of problems with overweight and obesity, compared with those in latitudes close to equator. There were a greater number of obese boys than girls. The most rapid increase of overweight and obesity issues in children occurred from ages 8-10 years, suggesting that this was a critical period in their development. Our findings suggest a geographical trend of a gradual increase in overweight and obesity issues from south to north. Weight management and physical activity programs for children aged 8-10 years could be effective for easing the increase among overweight and obesity.
THE EFFECT OF SERVICE QUALITY AND COMMUNITY RELATIONSHIP ON THE SATISFACTION OF MOTOR VEHICLES TAXPAYERS AT THE OFFICE WITH SAMSAT JEMBER

This study aims to determine the effect of service quality and public relations on the satisfactionof motor vehicle taxpayers in Samsat Jember. The type of research used is Explanatory Researchusing survey methods. The population in this study is the people of Jember who have motorizedvehicle taxpayers. The sampling technique used was a non-probability sampling technique,namely the Accidental Sampling approach. The sample in this study were 100 respondents. Thedata analysis method used is multiple linear regression analysis. The results of this study indicatethat the significant value of the service quality variable on the satisfaction of motorized vehicletaxpayers in Samsat Jember is 0.008 smaller than (0.05), this means that the service qualityvariable has a significant effect on community satisfaction at the Jember Samsat Joint Office.Then the significant value of the public relations variable on the satisfaction of motorized vehicletaxpayers in the Jember Samsat is 0.000 smaller than (0.05), this means that the public relationsvariable also has a significant effect on public satisfaction at the Jember Samsat Joint Office.Keywords: Service Quality, Public Relations, Satisfaction