Miracle-dz/UniFAR-FTUs huggingface dataset:
Aqueous film formation on irregularly shaped inorganic nanoparticles before deliquescence, as revealed by a hygroscopic differential mobility analyzer–Aerosol particle mass system

ABSTRACT A hygroscopic tandem differential mobility analyzer (H-TDMA) and a hygroscopic coupled DMA and aerosol particle mass (H-DMA-APM) were coupled to examine aqueous film formation and the deliquescence behavior of inorganic nanoparticles. The two systems complement each other because H-DMA-APM measures mass change, while H-TDMA measures mobility diameter (volume) change of nanoparticles upon water uptake. The former mass change was, in particular, more capable to discern minute particle phase changes than the latter size change at moderate RHs. The mass and diameter changes were used to derive the particle effective density for evaluation of aqueous film formation on the nanoparticle surface before and after deliquescence transition. The measurements further showed that approximately 3–5 and 12–20 monolayer equivalents of water molecules formed on the respective surface of 50- and 100-nm inorganic aerosols (ammonium sulfate and sodium chloride) before deliquescence relative humidity (DRH). These findings support the physical basis of the coated-surface model given by Russell and Ming in 2002, and suggest that the phase transition of inorganic nanoparticles near deliquescence is a gradual process instead of an abrupt change. This phenomenon changed the surface energy values, thus confirming the explanation that the DRH of nanoparticles increases as the particle size decreases. This is the first direct observation of nanoparticle deliquescence phase transition using the H-DMA-APM system, and the detailed characterization of aqueous film formation on inorganic nanoparticles is feasible with the presented measurement systems. © 2016 American Association for Aerosol Research
Electrochemical Behavior of Vanadium Compounds at Carbon Paste Electrode(CPE)

The electrochemical behavior of V 2O 3, V 2O 5 and NH 4VO 3 at carbon paste electrode(CPE) in H 2SO 4 solution were investigated by cyclic voltammetry. The results showed that for vanadium(Ⅲ) compound there appeared two reduction peaks but three oxidation peaks in cyclic voltammograms in different H 2SO 4 concentration solutions, while for two vanadium(Ⅴ) compounds there were four reduction peaks and four oxidation peaks, quite close to each other. The corresponding redox peaks were reasonably analyzed and the reaction mechanism has been discussed briefly.
Study on isolated Staphylococcus aureus from bovine milk with mastitis containing methicillin and Panton–Valentine leukocidin gene

Nowadays, bovine mastitis has been recorded as an inflammation of the mammary gland and Staphylococcus aureus is the main pathogens responsible for contagious mastitis in ruminants. Since milk is an important dairy product, present study seeks to evaluate presence of methicillin-resistant and PVL positive Staphylococcus aureus from bovine milk and evaluate is there any relationship between the presence of genes and antibiotic resistance or not? For this purpose, 100 milk samples were collected from cows affected with mastitis from four dairy farms in Fars province. The samples were transferred to MSA medium and incubated at 37‌° C for 24 hours. The pure colonies were identified by biochemical as well as molecular techniques using mecA, mecC and PVL gene. Then, the antibiotic pattern of the isolates was analyzed based on CLSI 2019 and whonet. Finally, the results were analyzed using statistical analysis. Totally, 6 S.aureus strains were detected which is confirmed by biochemical as well as molecular techniques. The isolates showed different antibiotic susceptibility patterns, most of the isolates were multidrug resistant, while, the strain No. 5 was the most sensitive one. Our results indicated presence of mecA gene in strains 1, 2 and 3, mecC in isolates 4, 5 and 6, and the pvl gene only reported in strain 4. According to the gained results, it could be concluded that, depending on the geographical region there is no relationship between presence of mecA, mecC, and pvl genes with antibiotics pattern.
Enablers and Barriers to Respectful Maternity Care in Low and Middle-Income Countries: A Literature Review of Qualitative Research

Background: Low and Middle-Income Countries (LMIC) account for 94% of maternal deaths annually. Interventions to reduce these deaths include; access to Emergency Obstetric Care (EmOC) and Skilled Birth Attendant (SBA) at childbirth. However, evidence indicates increasing access to EmOC, and SBA only does not translate into positive maternal and newborn outcome due to disrespectful care faced by women during labour. World Health Organization (WHO) guidelines emphasize on positive birth experience through Respectful Maternity Care (RMC). Therefore, this review aims to explore enablers and barriers to respectful maternity care in low and middle-income countries. Methods: We conducted an exhaustive literature search for studies that reported on enablers and barriers to respectful maternity care. Qualitative studies done in low and middle-income countries, published in English Language from the year 2000 to June 2020 were included in this study. Articles were screened by two researchers for eligibility and critical appraisal skills programme checklist was used to appraise the quality. The themes and quotes from the studies were extracted and synthesized using thematic synthesis. Results: The search strategy generated 14,190 articles and 54 studies met the inclusion criteria. Two main themes: interpersonal relationship and support, and privacy and confidential care were reported as both enablers and barriers to respectful maternity care. Strategies to promote RMC were: health education to pregnant women on care expected during labour, good communication between maternity staff and women, capacity building of staff on RMC and staff motivation. Conclusion: Respectful maternity care plays a big role in promoting health-seeking behaviours among pregnant women. However, women experience barriers ranging from provider behaviour, work environment and health system challenges. Ensuring a dignified and respectful working environment could contribute to an increase in health seeking-behaviours and consequently reduction of maternal mortality.
High-resolution MRI of a peroneal intraneural ganglion cyst arising from the knee joint: illustrative case

BACKGROUND The advancement of high-resolution imaging and increased clinical experience have led to an increased understanding of the formation and treatment of intraneural ganglion cysts. Nearly all intraneural ganglion cysts in the common peroneal nerve have been reported to arise from a joint connection to the superior tibiofibular joint. The authors have identified four cases of intraneural ganglion cysts arising from the knee joint itself; however, none of these reported cases were well described, documented, or illustrated with high-resolution imaging. OBSERVATIONS Here the authors present the case of an intraneural ganglion cyst arising from the knee joint and causing intermittent weakness and pain. The articular branch to the knee joint was clearly demonstrated on high-resolution magnetic resonance imaging and confirmed at surgical exploration. The patient was treated with articular branch ligation and has had complete resolution of his symptoms without recurrence of the cyst on follow-up imaging. LESSONS This case adds to the mounting evidence that intraneural cyst pathology is dependent on a connection to a synovial joint as stated in the unifying theory of intraneural cyst development.
Defluoridation of Aqueous Solution Using Thermally Activated Biosorbents Prepared from Adansonia digitata Fruit Pericarp

The presence of fluoride ions in water poses a significant danger to human health. In Tanzania, where the Rift Valley passes, some people are impaired due to elevated levels of fluoride in water. The purpose of this study was to prepare thermally activated Adansonia digitata fruit pericarp biosorbents at 450, 500, 550, and 600°C for defluoridation. Using the Brunauer-Emmett-Teller analyzer, the surface area and pore diameter were measured. The scanning electron microscope and Fourier transform infrared spectrometry were used to determine morphological features and functional groups of biosorbents. To analyze the effect of pH, adsorbent dose, contact time, and initial concentration, the response surface methodology was applied. Adsorption isotherms, kinetics, and regeneration studies were also conducted. There were considerably wide surface areas of 385.44, 399.27, 445.71, and 447.70 m2/g and pore diameters of 0.3055, 3.0341, 3.0375, and 3.0471 nm for biosorbents activated at 450, 500, 550, and 600°C, respectively. FT-IR spectra indicated the oxidation of alcoholic –OH to carboxylic –OH during the activation process, which is proved by the shifting of the peak at 3500-3000 cm-1 from raw biosorbent to a very broad and strong band at 3500-2000 cm-1 from the activated biosorbent. The maximum removal efficiencies of biosorbents activated at 450, 500, 550, and 600°C were 95.55, 96.50, 97.65, and 98.36%, respectively, for all biosorbents at a pH of 2, an initial concentration of 27.50 ppm, a contact period of 75.00 minutes, and an adsorbent dose of 5.50 g, which indicates that the adsorbents were successful for fluoride removal. The isotherms and kinetics indicated that the adsorption fitted well with Freundlich ( ) and pseudo-second-order ( ) kinetic adsorption models, respectively. The results showed that the removal of fluoride by biosorbents prepared is effective and could be used for defluoridation of drinking water.
Effects of land‐use on fruit bat distribution in different habitats along the slopes of Mt. Kilimanjaro, Tanzania

Tropical ecosystems are currently degrading at unprecedented speed, mostly due to rapid human population growth. This affects the associated biodiversity, which frequently results in damage to or loss of ecosystem functions. Due to high species richness and ecological diversity, bats are essential ecosystem elements. Our objective was to determine effects of land‐use categories on species abundance, richness and diversity of the guild of fruit bats (Chiroptera: Pteropodidae) on Mt. Kilimanjaro, a biodiversity hotspot in Tanzania. We surveyed five habitat types, including two natural habitats lower montane forest and savanna, and three disturbed habitats, coffee plantations, Chagga homegardens, and maize fields. We captured 629 frugivorous bats and (1) compared diversity and species abundance among the habitat types and (2) assessed factors driving the differences in guild structure along an elevational gradient. Species accumulation curves were asymptotic for all habitats, suggesting an adequate sampling effort. Non‐metric multidimensional scaling analysis indicated strong differentiation of fruit bat guilds among habitats. Highest species richness was recorded in lower montane forest and Chagga homegardens, which therefore represent habitats of high value for these bats. Nevertheless, even in the intensively used coffee plantations and maize fields we found a high abundance of bats from most species despite a low abundance of food resources. Our results suggest that bats do not perceive moderately sized plantations as a hostile matrix, but rather use them as flyways between fragments and patches of secondary vegetation. Further, we suggest that within plantations, trees like Ficus spp. increase bat activity.
Bibliotherapy as a Tool of Education in Classroom

Books are the richest source of knowledge to get information and learn about looking from a third perspective at the bigger picture. They assist in our growth and help build our imaginative and creative bent of mind. Bibliotherapy as creative arts modality of therapy is not just something that can be used only in the clinical settings but also in what we loosely characterize as a general and daily place of work like a classroom and school. The current review paper aims to highlight vital aspects of how bibliotherapy can be used in classrooms, especially on children and young adults as a part of our general curriculum, to help build and transform the upcoming generations as mentally healthy beings. The magnitude of impact that bibliotherapy can have on young minds to educate them more on inclusivity of different communities, learning about cultures, enhancing the social-emotional learning, and in severe cases, the use of bibliotherapy can help them identify with difficulties they face and build empathy and a sense of normalizing. Throughout, we uncover shreds of evidence of how books help kids to connect better not just with the outer world but with themselves as well. Lastly, the current review brings out further suggestions to study that can be done and how concepts like bullying, sex education, and gender identification & roles can be taught better with the help of books and teach also inclusivity to kids at a young age and broaden their horizons.
Narcissism and Subjective Arousal in Response to Sexual Aggression: The Mediating Role of Perceived Power

The present research examined the associations that narcissistic personality features had with subjective arousal in response to sexually aggressive behaviors, as well as whether these associations were mediated by the power that was believed to accompany these behaviors. Participants were 221 community members (115 women, 106 men) who completed a self-report instrument that captured narcissistic admiration (an agentic form of narcissism) and narcissistic rivalry (an antagonistic form of narcissism). In addition, participants were asked to rate how powerful they would expect to feel if they actually engaged in an array of sexually aggressive behaviors (e.g., “Tying up a person during sexual intercourse against her/his will”) as well as how sexually aroused they would be by each behavior. A multilevel mediation analysis revealed that both narcissistic admiration and narcissistic rivalry were positively associated with subjective arousal in response to sexual aggression and that these associations were mediated by the perceived power that was believed to accompany these sexually aggressive behaviors. These results suggest that perceptions of power may play an important role in the connections that narcissistic personality features have with subjective arousal in response to sexually aggressive behavior for both men and women. This discussion will focus on the implications of these results for understanding the connections between narcissism and sexual aggression in both men and women.
Results from the phase Ib of the SENSITIZE trial combining domatinostat with pembrolizumab in advanced melanoma patients refractory to prior checkpoint inhibitor therapy.

9545 Background: Anti-PD-1 +/- anti-CTLA4 antibodies are the current standard of care immunotherapy for advanced melanoma. However, a significant proportion of patients do not achieve disease control. Epigenetic modulation, particularly histone deacetylase (HDAC) inhibition, can overcome tumor escape mechanisms and thus might increase the susceptibility to immunotherapy. Methods: Advanced unresectable/metastatic cutaneous melanoma patients primary refractory or non-responding to prior checkpoint inhibitor (CI) therapy were treated with domatinostat at 5 different dose levels (DL) (100 mg (QD), 200 (QD), and 200 mg (BID) using two different schedules (D1-14 and D1-21 q3w) in combination with pembrolizumab (2 mg/kg) q3w to evaluate safety and tolerability. Tumor assessments were performed every 12 weeks and assessed using irRECIST. Sequential tumor biopsies were taken for gene expression analysis and peripheral blood for pharmacokinetic (PK) analysis. Results: We report on preliminary results from the phase Ib part of the ongoing study, data cut-off Feb 1st, 2021 a total of 40 patients have been enrolled. Patient characteristics show that the median number of pretreatments at stage IV was 3, 65 % of patients stage M1c (AJCC 7 or 8) and 35 % with elevated LDH at trial inclusion. Treatment emergent adverse events (AEs) related to domatinostat reported in ≥ 10% of patients were: diarrhea (23%), nausea (20%), fatigue (20%), rash (15%), pyrexia (13%), blood alkaline phosphatase increased (13%), vomiting (10%), dyspnea (10%), all grade 1 and 2 - except one maculo-papular rash grade 3. In total, 8 patients (20 %) developed ≥ grade 3 AEs, with no treatment-related deaths. Patterns of AEs resembled the known safety profiles of domatinostat and pembrolizumab with no increase of immune related AEs for the combination. Maximum tolerated dose was not reached. Four patients discontinued treatment per protocol due to AEs grade 3. We observed clinical activity with 1 complete response, 2 confirmed partial responses and 9 stable diseases (6 confirmed), resulting in a disease control rate of 30% in highly pretreated patients throughout all DLs. Notably, 3 out of 7 patients achieved disease control in DL 3 (domatinostat 200 mg BID D1-14, q3w) and were on treatment ≥ 1.5 years, indicating a trend of dose-dependent clinical activity. Domatinostat treatment resulted in a trend to higher intra-tumoral expression of MHC/APM genes and a more inflamed tumor microenvironment reflecting enhanced T cell infiltration. Conclusions: The combination of domatinostat and pembrolizumab was safe and well tolerated. The observed clinical activity in advanced melanoma patients refractory to previous checkpoint inhibition and the favorable translational findings warrant further development of domatinostat in combination with CI in melanoma and beyond. Clinical trial information: NCT03278665.
Case series of mucormycosis occurring in patients of COVID-19

Mucormycosis is an umbrella term used for diseases caused by many non-septate filamentous fungal species which is caused by sub-phylum Mucormycotina. It is an acute opportunistic and aggressive fulminant invasive infection that can occur in immunocompromised patients, such as uncontrolled diabetes, renal failure, organ transplant, long-term corticosteroid and immunosuppressive therapy, AIDS, malignancy and corona virus disease 2019 (COVID 19) infections. Mucormycosis is now third most common invasive mycoses after candidiasis and aspergillosis. The COVID19 infection is characterised by wide range of disease patterns, ranging from mild to life-threatening pneumonia. Many bacterial and fungal co-infections may exist and may be associated with preexisting morbidity or may develop as a hospital-acquired infection such as ventilator-associated pneumonia. Extensive use of corticosteroids and broadspectrum antibiotics lead to exacerbation of preexisting disease. The aim of this study is to identify the risk factors along with high index of suspicion, early diagnosis and aggressive management of mucormycosis.
Cooperation between Preschool Teachers and Parents from the Perspective of the Developmental Status of the Child

ABSTRACT The aim of this study was to determine the perceptions of preschool teachers and parents about their cooperation and to examine whether there are differences in the perception of this cooperation regarding the status of the respondents’ children (children of typical development and children with developmental disabilities). The assessment of cooperation was conducted by using the Family Involvement Questionnaire – FIQ (Fantuzzo, Tighe, & Childs, 2000), adapted for the purposes of this study. The results show that there is a statistically significant difference between the perceptions of preschool teachers and parents regarding parental involvement in preschool activities (Z=-5.614; p<.01). Parents consider that they participate in preschool activities to a higher extent than perceived by preschool teachers. There is a statistically significant difference in the perception of preschool teachers regarding their cooperation with parents of children of typical development and with parents of children with developmental disorders (Z=-2.38; p<.05), whereby preschool teachers notice that they have a better cooperation with parents of children of typical development. It can be concluded that there is a need for planning guidelines and implementing practical procedures that would contribute to better cooperation between preschool institutions and parents of children with developmental disabilities.
Interlaboratory CEC and Exchangeable Cation Study of Bentonite Buffer Materials: I. Cu(II)-Triethylenetetramine Method

Bentonites are candidate materials for encapsulation of radioactive waste. The cation exchange capacity (CEC) has proved to be one of the most sensitive parameters for detecting changes of mineral properties such as swelling capacity and illitization in alteration experiments. Whether measured differences in CEC values of bentonite buffer samples before and after an experiment are (1) actual differences caused by clay structural changes such as illitization or (2) simply data scatter due to the different methods used by international research teams is an open question. The aim of this study was to measure the CEC of clay samples in five different laboratories using the same method and to evaluate the precision of the values measured. The Cu-trien method and four reference materials of the Alternative Buffer Material (ABM) test project in Äspö, Sweden, were chosen for this interlaboratory study. The precision of the Cu-trien method, which uses visible spectroscopy, was very good with a standard deviation of ±0.7–2.1 meq/100 g for CECs that ranged from 11 to 87 meq/100 g. For the same CEC range, analysis of Cu-trien index cations using inductively coupled plasma (mass spectrometry) and atomic absorption spectroscopy were less precise with a standard deviation of ±2.8–3.9 meq/100 g. Based on the measured precision, greater measured differences in Cu-trien CEC and exchangeable cation values of bentonite buffer samples, before and after an experiment, might be actual differences. Great care must be taken when interpreting measured CEC differences, and analytical characterization of any structural changes may be needed. Compared with results from the ‘International Soil-Analytical Exchange’ (iSE) program for soils, most absolute concentrations were much larger for the clays studied; however, for the two parameters exchangeable Ca2+ and CEC the range was similar to the iSE ring test and, most importantly, the precision was comparable. Future studies should discuss the accuracy of CEC and exchangeable cation values and compare them to alternative CEC methods in which care is taken to prevent dissolution of soluble minerals, such as calcite and gypsum.
Quality of Life Effects of an Oral Fixed Combination of Netupitant and Palonosetron in Chemotherapy-Induced Nausea and Vomiting Prevention: Real-World Evidence in Patients with Breast Cancer Receiving Anthracycline-Cyclophosphamide-Based Chemotherapy

Introduction: In a prospective non-interventional study involving 2,173 patients, we showed that use of the oral fixed combination of netupitant 300 mg and palonosetron 0.5 mg (NEPA) for prevention of chemotherapy (Ctx)-induced nausea and vomiting has beneficial effects on the quality of life (QoL) of patients with various types of cancers receiving highly or moderately emetogenic Ctx. Here, we report on the effects on QoL, effectiveness, and tolerability of NEPA in patients with breast cancer exposed to anthracycline-cyclophosphamide (AC)-based Ctx. Methods: This is a post hoc subanalysis of a prospective non-interventional study in 1,197 patients with breast cancer receiving up to 3 cycles of doxorubicin or epirubicin plus cyclophosphamide and NEPA. NEPA administration was per the summary of product characteristics. Results: In cycle 1 of Ctx, a large proportion of patients (84%) reported “no impact on daily life” (NIDL) due to vomiting; 53% of patients reported NIDL due to nausea. The complete response rate was 86/88/81% in the acute/delayed/overall phase in cycle 1, and NEPA was well tolerated throughout the study. Conclusion: The real-world beneficial effects of NEPA prophylaxis on QoL were confirmed for patients with breast cancer receiving AC. NEPA was effective with a good safety profile in this patient population in clinical practice.