Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of tomato processing by-product extract as dietary supplementation on growth performance, carcass characteristics and antioxidant status of growing rabbits under high ambient temperature

Abstract This study evaluated the effects of dietary supplementation of tomato processing by-product extract (TPBE) on growth performance, carcass characteristics and antioxidant status of growing rabbits under high ambient temperature. A total of eighty weaned New Zealand White (NZW) male rabbits (6-weeks-old; initial body weight, 730.28 ± 36.05 g) were randomly assigned to 4 groups. The first group was the control without supplementation; while the other groups were fed diets supplemented with 100, 200 and 250 mg TPBE/kg. The results showed that TPBE contained 211.85 mg/100g as total phenols and total flavones of 303.36 mg/100g. Rabbits fed a 250 mg TPBE-supplemented diet showed the heaviest body weight, the lowest feed intake and the best feed conversion ratio. TPBE diets reduced mortality percentage. Dietary supplementation of 250 mg TPBE had the highest dressing percentage. Plasma total protein, globulin, catalase and glutathione peroxidase of rabbits fed diets supplemented with 200 and 250 mg TPBE were high. Plasma total cholesterol, triglycerides, plasma hydrogen peroxide and malondialdehyde concentrations were decreased with dietary levels of TPBE. Rabbits fed 250 mg TPBE had higher T-AOC than the other groups. TPBE supplemented diets improved net revenue and economic efficiency. Conclusively, TPBE is containing appreciable content of polyphenols and flavonoids and the dietary supplementation of TPBE (250 mg/kg diet) had a positive impact on growth performance, reducing mortality and enhancing the antioxidant status of rabbits reared under high ambient temperature.
Frequent Violations and Infringements against Users in Mental Health Care Confirmed by Both Users and Professionals – A Quantitative Study

Abstract The main task of mental health care services is to provide good quality of care. Despite this, users are sometimes treated badly by staff. The purpose of this study was to investigate violations and infringements towards users in mental health care services, from the perspectives of both staff and users. Data were gathered through an anonymous online questionnaire sent to staff and users in Norway. Staff were recruited in collaboration with professional organisations and users in collaboration with user-organisations.
Feasibility of wireless cardiorespiratory monitoring with dry electrodes incorporated in a belt in preterm infants

Objective. Monitoring heart rate (HR) and respiratory rate (RR) is essential in preterm infants and is currently measured with ECG and chest impedance (CI), respectively. However, in current clinical practice these techniques use wired adhesive electrodes which can cause skin damage and hinder parent-infant interaction. Moreover, CI is not always reliable. We assessed the feasibility of a wireless dry electrode belt to measure HR and RR via transcutaneous diaphragmatic electromyography (dEMG). Approach. In this prospective, observational study, infants were monitored up to 72 h with the belt and standard CI. Feasibility of the belt was expressed by its ability to retrieve a respiratory waveform from dEMG, determining the percentage of time with stable respiration data without signal errors (‘lead-off’ and Bluetooth Loss Error, ‘BLE’), skin-friendliness of the belt (skin score) and by exploring the ability to monitor trends in HR and RR with the belt. Main results. In all 19 included infants (median gestational age 27.3 weeks) a respiratory waveform could be obtained. The amount of signal errors was low (lead-off 0.5% (IQR 0.1–1.6) and BLE 0.3% (IQR 0.1–0.9)) and 76.5% (IQR 69.3–80.0) of the respiration measurement was stable. No adverse skin effects were observed (median skin score of 3(3–4)). A similar HR and RR trend between the belt and CI was observed. Significance. Dry electrodes incorporated in a non-adhesive belt can measure dEMG in preterm infants. The belt provided a HR and RR trend similar to CI. Future studies are required to investigate the non-inferiority of the belt as a cardiorespiratory monitor compared to CI.
CEUS‐assessed supraspinatus muscle perfusion improves after tendon repair and predicts anatomical and functional outcome: A 1‐year prospective pilot study

Rotator cuff tear including SSP (Supraspinatus) tendon tears are a very common and often painful condition with several therapeutic options such as tendon repair. Reflected by the high retear rates, the preoperative selection of patients suitable for surgery or conservative treatment, which often yields comparable results, remains difficult. Using contrast‐enhanced ultrasound (CEUS), it is possible to quantify the SSP muscle perfusion as a surrogate parameter for its vitality and healing capabilities. In this study, we enrolled 20 patients who underwent an SSP repair for a preoperative and two postoperative (6 months and 1 year) clinical and sonographic exams including CEUS. Along with functional improvement (p < 0.001, Constant score), we found a significant increase in CEUS‐assessed muscle perfusion after tendon repair (p < 0.001). Furthermore, weak preoperative muscle perfusion was associated with a higher risk of a retear (χ2 = 0.045) and a moderate trend toward lower postoperative shoulder function that did not reach significance (r = 0.435; p = 0.055, DASH score). If confirmed in larger studies, CEUS might be a valuable additional diagnostic method for a precise selection of patients who most likely profit from a tendon repair and those who can be treated conservatively with an equally good outcome.
Fish Species Sensitivity Ranking Depends on Pesticide Exposure Profiles

In the regulatory environmental risk assessment of plant protection products, the exposure tested in standard toxicity tests assumes simple exposure dynamics, such as constant exposure at the first stage of testing. However, environmental exposure can be highly dynamic. A species response to exposure is governed by toxicokinetics (TK) and toxicodynamics (TD). Therefore, it can be expected that the sensitivity of a species to a substance is dependent on the interplay of TKTD processes with the dynamics of the exposure. We investigated whether exposure dynamics affects species sensitivity of five fish species and if their sensitivity rankings differ among exposure profiles. We analyzed individual survival under projected surface water exposure to benzovindiflupyr. For this purpose, we calibrated compound‐ and species‐specific reduced general unified threshold models of survival (GUTS‐RED) models from standard laboratory toxicity data with the assumptions of stochastic death and individual tolerance. Using the calibrated models, we generated species sensitivity distributions based on median lethal profile multiplication factors for three characteristic exposure profiles. The analysis was performed using different GUTS‐RED implementations: openGUTS (MATLAB® and Windows® versions) and the R package morse. The sensitivity rankings of the fish species changed as a function of exposure profile. For a multiple‐peak scenario, rainbow trout was the most sensitive species. For a single peak followed by a slow concentration decline the most sensitive species was the fathead minnow (GUTS‐RED‐stochastic death) or the common carp (GUTS‐RED‐individual tolerance). Our results suggest that a single most sensitive species cannot be defined for all situations, all exposure profiles, and both GUTS‐RED variants. Environ Toxicol Chem 2022;41:1732–1741. © 2022 Syngenta. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Progress in the development of tissue-based biomarkers for urothelial cancer

ABSTRACT Introduction As the understanding of molecular mechanisms of bladder cancer advances, molecularly-guided precision medicine becomes increasingly relevant. Biomarkers play a critical role in this setting, predicting treatment response and identifying candidates for targeted therapies. Areas covered Current literature on biomarkers in their role in disease prognosis and response to neoadjuvant and adjuvant therapies. In non-muscle invasive bladder cancer, particular focus is on markers of disease progression, and response to intravesical therapy. In muscle invasive and advanced bladder cancer, particular emphasis is on markers associated with neoadjuvant chemotherapy, as well as systemic immunotherapy. We discuss current shortcomings and pitfalls in contemporary markers, and future avenues of prospective research. Expert opinion The focus on biomarkers has moved from immunohistochemical analysis and tumor-related phenotypic changes to examining genetic alterations. Single marker analysis has been shown to be insufficient in predicting both disease course and response to therapy, and studies have shifted toward examining marker combinations and genetic classifiers. Ultimately, significant progress in implementing biomarkers into clinical guidelines remains elusive, largely due to lack of prospective studies in well-defined patient cohorts and with clinically meaningful endpoints. Until then, despite their promising value, tissue markers should be limited to experimental settings and clinical trials.
Acceptance of an Internet-Based Team Development Tool Aimed at Improving Work-Related Well-being in Nurses: Cross-sectional Study

Background Workplace health interventions can produce beneficial health- and business-related outcomes. However, such interventions have traditionally focused on lifestyle behaviors of individuals, mostly not considering the role of working conditions. The wecoach intervention is an internet-based tool that combines both a digital and a participatory team development approach aimed at addressing critical job demands and resources as key aspects of health-promoting working conditions. Nursing staff are particularly affected by challenging working conditions and could potentially benefit greatly. Understanding the acceptance of novel workplace health promotion approaches is a critical precursor to their successful implementation and use. Objective This study aims to examine the factors influencing the acceptance of a digitally supported team development tool among nurse managers. Methods A sample of 32 nurse managers from 3 German-speaking countries tested wecoach and completed our online questionnaire. Hypotheses were based on the unified theory of acceptance and use of technology (UTAUT) and the organizational health development (OHD) model and were tested using multiple regression analyses. Results Our analyses found that merely capacities on the team level (CapTeam) significantly contributed to the acceptance of wecoach, although only after the other variables were excluded in the stepwise multiple regression analysis. The UTAUT predictors were unable to add significant variance explanation beyond that, and their inclusion masked the contribution of CapTeam. Conclusions For the acceptance of a digitally supported participatory tool, the fit with the team, its culture, and its motivation are of critical importance, while aspects proposed by traditional acceptance models, such as the UTAUT, may not be applicable.
Astrocyte regulation of neural circuit activity and network states

Astrocytes are known to influence neuronal activity through different mechanisms, including the homeostatic control of extracellular levels of ions and neurotransmitters and the exchange of signaling molecules that regulate synaptic formation, structure, and function. While a great effort done in the past has defined many molecular mechanisms and cellular processes involved in astrocyte‐neuron interactions at the cellular level, the consequences of these interactions at the network level in vivo have only relatively recently been identified. This review describes and discusses recent findings on the regulatory effects of astrocytes on the activity of neuronal networks in vivo. Accumulating but still limited, evidence indicates that astrocytes regulate neuronal network rhythmic activity and synchronization as well as brain states. These studies demonstrate a critical contribution of astrocytes to brain activity and are paving the way for a more thorough understanding of the cellular bases of brain function.
Service Encounter-Based

This chapter argues that substantial potential exists for service encounter-based innovation in tourism. However, there are also a number of obstacles. Based on theoretical discussions on potentials and obstacles, a Knowledge Chain Model of service encounter-based innovation in tourism is developed. It suggests how weak or broken knowledge chains limit companies’ potential for benefiting from service encounter-based innovation. The relevance of the model is illustrated by a comparative case study of four tourism companies. In light of the theoretical frameworks and empirical findings, the chapter suggests how experimental methods can join research and practice to enhance the innovative potential of tourism companies while providing the research community with valuable knowledge.
Characterization of stage‐specific tumor progression in TMPRSS2‐ERG (fusion)‐driven and non‐fusion‐driven prostate cancer in GEM models

In the present study, we performed a comparative stage‐specific pathological and molecular marker evaluation of TMPRSS2‐ERG fusion and PTEN loss‐driven (TMPRSS2‐ERG. Ptenflox/flox) versus non‐fusion‐driven prostate tumorigenesis (Hi‐Myc) in mice. Anterior, ventral, and dorsolateral prostates were collected from mice at different ages (or time points post‐Cre induction). Results indicated that growth and progression of prostatic intraepithelial lesions to adenocarcinoma stages occurred in both mice models albeit at different rates. In the TMPRSS2‐ERG. Ptenflox/flox mice, the initiation of tumorigenesis was slow, but subsequent progression through different stages became increasingly faster. Adenocarcinoma stage was reached early on; however, no high‐grade undifferentiated tumors were observed. Conversely, in the Hi‐Myc+/− mice, tumorigenesis initiation was rapid; however, progression through different stages was relatively slower and it took a while to reach the more aggressive phenotype stage. Nevertheless, at the advanced stages in the Hi‐Myc+/− mice, high‐grade undifferentiated tumors were observed compared to the later stage tumors observed in the fusion‐driven TMPRSS2‐ERG. Ptenflox/flox mice. These results were corroborated by the stage specific‐pattern in the molecular expression of proliferation markers (PCNA and c‐Myc); androgen receptor (AR); fusion‐resultant overexpression of ERG; Prostein (SLC45‐A3); and angiogenesis marker (CD‐31). Importantly, there was a significant increase in immune cell infiltrations, which increased with the stage of tumorigenesis, in the TMPRSS2‐ERG fusion‐positive tumors relative to fusion negative tumors. Together, these findings are both novel and highly significant in establishing a working preclinical model for evaluating the efficacy of interventions during different stages of tumorigenesis in TMPRSS2‐ERG fusion‐driven PCa.
Tricuspid Regurgitation in Congestive “End-Organ” Failure: Outline of an Opportunity

Tricuspid regurgitation (TR) is a progressive disease that can be addressed only partially by medical therapy. Progression of TR is associated with worsening end-organ function and worse survival, yet tricuspid valve interventions are usually only performed in advanced stages. Recent evidence suggests a pivotal role for TR and pulsatile venous congestion in the pathophysiology of renal and hepatic dysfunction. This critical knowledge has provided the opportunity to optimally define the appropriate timing of transcatheter tricuspid valve interventions, integrating concurrent or impending functional consequences with severity of TR.
A value of information framework for assessing the trade-offs associated with uncertainty, duration, and cost of chemical toxicity testing

A number of investigators have explored the use of value of information (VOI) analysis to evaluate alternative information collection procedures in diverse decision‐making contexts. This paper presents an analytic framework for determining the value of toxicity information used in risk‐based decision making. The framework is specifically designed to explore the trade‐offs between cost, timeliness, and uncertainty reduction associated with different toxicity‐testing methodologies. The use of the proposed framework is demonstrated by two illustrative applications which, although based on simplified assumptions, show the insights that can be obtained through the use of VOI analysis. Specifically, these results suggest that timeliness of information collection has a significant impact on estimates of the VOI of chemical toxicity tests, even in the presence of smaller reductions in uncertainty. The framework introduces the concept of the expected value of delayed sample information, as an extension to the usual expected value of sample information, to accommodate the reductions in value resulting from delayed decision making. Our analysis also suggests that lower cost and higher throughput testing also may be beneficial in terms of public health benefits by increasing the number of substances that can be evaluated within a given budget. When the relative value is expressed in terms of return‐on‐investment per testing strategy, the differences can be substantial.
Retrospective, matched case–control analysis of tickborne encephalitis vaccine effectiveness by booster interval, Switzerland 2006–2020

Objective To estimate effectiveness of tickborne encephalitis (TBE) vaccination by time interval (<5, 5–10 and 10+years) postvaccination. Design A retrospective, matched case–control study Participants Cases—all adult (age 18–79) TBE cases in Switzerland reported via the national mandatory disease reporting surveillance system from 2006 to 2020 (final n=1868). Controls—community controls from a database of randomly selected adults (age 18–79) participating in a 2018 cross-sectional study of TBE vaccination in Switzerland (final n=4625). Primary outcome measures For cases and controls, the number of TBE vaccine doses received and the time since last vaccination were determined. Individuals were classified as being ‘unvaccinated’ (0 doses), ‘incomplete’ (1–2 doses) or ‘complete’ (3+ doses). Individuals with ‘complete’ vaccination were further classified by time since the last dose was received (<5 years, 5–10 years or 10+ years). A conditional logistic regression model was used to calculate vaccine effectiveness (VE: 100 × [1−OR]) for each vaccination status category. Results VE for incomplete vaccination was 76.8% (95% CI 69.0% to 82.6%). For complete vaccination, overall VE was 95.0% (95% CI 93.5% to 96.1%). When the most recent dose was received <5 years prior VE was 91.6% (95% CI 88.4% to 94.0%), 95.2% (95% CI 92.4% to 97.0%) when the most recent dose was received 5–10 years prior, and 98.5% (95% CI 96.8% to 99.2%) when the most recent dose was received 10+ years prior. Conclusions That VE does not decrease among completely vaccinated individuals over 10+ years since last vaccination supports the longevity of the protective response following complete TBE vaccination. Our findings support the effectiveness of 10-year TBE booster intervals currently used in Switzerland.
Substitution of garlic leaves to alfalfa hay and its effect on in vitro ruminal fermentation

This research aimed to evaluate the substitution of alfalfa hay to garlic leaves during the in vitro gas and methane production, as well as in ruminal fermentation patterns. There were four treatments: (T1) alfalfa hay (50%); (T2) alfalfa hay (33%) + raw garlic leaves (17%); (T3) alfalfa hay (17%) + raw garlic leaves (33%) and (T4) raw garlic leaves (50%). The highest values of "a" (gas production from the soluble fraction); "b" (gas production from the insoluble fraction) and "c" (gas production rate) were found in T4 (mL). While lower in T1 (P<0.05); but no differences were observed between T2 and T3 (P>0.05). The highest ammonia-nitrogen (NH3-N) concentration was recorded in T4 and the lowest in T1 (P<0.05). The propionate concentrations increased with T4 and decreased with T1, whereas the acetate decreased with T4 and increased with T1 (P<0.05). The highest methane production was recorded in T1 and the lowest in T4 (P<0.05). It is concluded that substitution of alfalfa hay to garlic leaves in beef cattle diets, improved the ruminal fermentation and decreased methane production under in vitro conditions.
The Bright and Dark Sides of Emotional Intelligence: Implications for Educational Practice and Better Understanding of Empathy

In recent years, educational practitioners have become more aware of the importance of cultivating students’ social and emotional skills, in order to facilitate adaptation beyond academic contexts. Emotional intelligence (EI), the ability to regulate one’s own and others’ emotions appropriately, has often been targeted in educational interventions. Previous studies suggest that EI promotes various positive social outcomes such as social support, prosocial behaviour, and subjective well-being. However, a growing body of research has also shown that EI may sometimes lead to antisocial behaviours such as indirect aggression and support for others’ retaliation, but this “darker side” of EI tends to be overlooked. We argue that emotional intelligence without empathy can bring about manipulative or aggressive behaviour, and highlight the need to explore further how EI interacts with other personality traits in determining different social outcomes. This review addresses both the “bright” and the “dark” side of EI, aiming to offer a comprehensive, balanced perspective on its adaptive functions. Based on Reinforcement Sensitivity Theory (RST), our paper proposes that there might be a common mechanism by which EI links to both prosociality and aggression. Our analysis leads to the conclusion that researchers need to elaborate on the motivational mechanism underlying the behaviours of emotionally intelligent individuals, while teachers would be well-advised to pay attention to the motivations that support students’ socially adaptive behaviours. conducted surveys on which EI predicts GPA. that predicts academic performance via two sets of mediators: (1) perceived social adjustment, in turn academic performance; (2) engagement coping, academic adjustment, in turn academic performance. results that EI predicts social support personal adjustment, there was a non-significant relationship between psychological and academic performance controlling for the effect of academic achievement.