Miracle-dz/UniFAR-FTUs huggingface dataset:
The Safety and Feasibility of Lower Body Positive Pressure Treadmill Training in Individuals with Chronic Stroke: An Exploratory Study

Background: Lower body positive pressure (LBPP) may provide a novel intervention for gait training in neurological conditions. Nonetheless, studies investigating the safety and feasibility of LBPP in patients with stroke are insufficient. Objectives: The purpose of this study was to evaluate the safety and feasibility of LBPP as a rehabilitation intervention for individuals with chronic stroke. Methods: Individuals with chronic stroke were recruited from the community to participate in LBPP gait training three times a week for six weeks. The LBPP’s safety and feasibility were documented throughout the study and at the end of six weeks. Safety and feasibility referred to the incidence of adverse events, complications, the participant and therapist satisfaction questionnaire, and the device limitation including but not limited to technical issues and physical constraints. In addition, blood pressure, pulse rate, and oxygen saturation were taken pre- and post-session. Dependent t-tests were used to analyze the difference between assessments. A Wilcoxon test was used to assess the ordinal data (Trial registration number NCT04767334). Results: Nine individuals (one female, eight males) aged 57 ± 15.4 years were enrolled. All participants completed the intervention without adverse events. All participants reported positive scores from 4 (very satisfying) to 5 (extremely satisfying) in the safety and feasibility questionnaire. No significant differences were observed in blood pressure and oxygen saturation during the intervention sessions. However, significant increases were observed in heart rate from 82.6 ± 9.1 beats/min (pre-session) to 88.1 ± 6.8 beats/min (post-session) (p = 0.027). Conclusions: LBPP is a safe and feasible rehabilitation tool to use with individuals with chronic stroke.
High-temperature carrier transport and thermoelectric properties of heavily La- or Nb-doped SrTiO3 single crystals

Electron and thermal transport properties, i.e., electrical conductivity, carrier concentration, Hall mobility, Seebeck coefficient, thermal conductivity, of heavily La- or Nb-doped SrTiO3 (STO) bulk single crystals were measured at high temperatures, (300–1050K) to clarify the influence of doping upon the thermoelectric performance of STO. The temperature dependence of Hall mobility and Seebeck coefficient changed at ∼750K in all samples because the dominant mechanism for carrier scattering changed with increasing temperature from coupled scattering by polar optical phonons and acoustic phonons to mere acoustic phonon scattering. The density-of-states effective mass of Nb-doped STO, which was estimated from the carrier concentration and Seebeck coefficient, was larger than that of La-doped STO. Thermal conductivity of the samples, which was similar to that of undoped STO single crystal, decreased proportionally to T−1, indicating that the phonon conduction takes place predominantly and the electronic con.
Association between tooth loss and risk of occurrence of oral cancer – A systematic review and meta-analysis

ABSTRACT Background: Periodontitis, the second most common reason for tooth loss in adults, is a chronic inflammatory condition that increases the prevalence of cancer by inhibiting apoptosis and promoting tumor cell growth. However, it is still debatable if tooth loss is an important risk factor in oral cancer (OC). The aim of this systematic review is to analyze the relationship between tooth loss and the probability of developing head-and-neck cancer and also to see if there is an association between tooth loss, periodontitis, and the risk of OC. Materials and Methods: Studies that depicted a link between tooth loss and OC (till 2017) were searched from online databases accompanied by a thorough manual search of relevant journals. Data were collected from eligible studies, and meta-analysis was carried out using the Meta-Analysis software. The effect of various inclusions was assessed by sensitivity and subgroup analysis. Publication bias was also evaluated. Results: The meta-analysis consisted of 15 publications. When the number of teeth lost was counted, there was significant variability (I2 = 98.7%, P = 0.0001). When more than 15 teeth were missing in a subgroup analysis, there was a 2.4 times greater risk of OC (odds ratio: 2.496, 95% confidence interval [CI] = 2.067–3.015, P = 0.001) with no heterogeneity (I2 = 0.00%, 95% CI for I2 = 0.00–68.98). Subgroup analysis revealed that there was no evidence of publication bias. Conclusion: It was concluded that tooth loss can increase the OC risk by nearly 2 folds. However, large-scale population-based studies are needed to substantiate the findings.
Doppler imaging of stellar non-radial pulsations. I. Techniques and numerical experiments

We present a novel technique aimed at the investigation of the geometry of surface velocity fluctuations in non-radially pulsating stars. Our method is based on the Doppler imaging principle and enables an accurate reconstruction of a two-dimensional map of the pulsational disturbances using spectroscopic time-series observations. No specific assumptions on the shape of the pulsation geometry are made. This opens a unique possibility to go beyond the traditional mode identification analyses and study complex rotationally and magnetically distorted non-radial pulsation modes which cannot be described by a single spherical harmonic function. Performance and intrinsic limitations of the new Doppler imaging procedure are assessed with inversions of simulated data. Based on the results of these numerical tests we conclude that a reliable recovery of the surface pulsation velocity structures can be achieved for all types of pulsation geometries accompanied by significant line profile variations. It is also demonstrated that the Doppler mapping of the pulsation velocity field is remarkably robust with respect to errors in the adopted stellar parameters.
Numerical estimates of drift loss and Dst effect for outer radiation belt relativistic electrons with arbitrary pitch angle

[1] Satellite observations often show that relativistic electron fluxes that decrease during a geomagnetic storm main phase do not recover their prestorm level even when the storm has substantially recovered. A possible explanation for such sustained flux dropout is that the electrons that move to larger shells (L shells) aided by the disturbance storm time (Dst) effect associated with the main phase geomagnetic field depression may be suffering drift loss to the magnetopause, resulting in irreversible (nonadiabatic) flux decreases during a geomagnetic storm. In this study, we have numerically evaluated the drift loss effect by combining it with the Dst effect and including off-equatorially mirroring electrons for three different storm conditions obtained by averaging 95 geomagnetic storms that occurred from 1997 to 2002. Using the Tsyganenko T02 model and our own simplified method, we estimated the storm time flux changes based on the guiding center orbit dynamics. Assuming that there is no competing source mechanism taking place at the same time, our calculations of the electron fluxes at equatorial midnight suggest that the drift loss when combined with the Dst effect can be responsible for flux dropouts, which can be seen even inside the geosynchronous orbit during storm periods. Specifically, by evaluating omnidirectional flux values at three specific times that correspond to the storm onset time, the time of minimum Dst value, and the end of the Dst recovery, we have obtained the following numerical results. First, for the strong storm with −150 nT < Dstmin ≤ −100 nT, the combined drift loss and Dst effect can cause a complete dropout of the electron flux for r ≥ ∼5 RE at the end of the storm recovery. A nearly full recovery of the particle flux by the adiabatic Dst effect is seen only for r < ∼5 RE. For the moderate storm with −100 nT < Dstmin ≤ −50 nT, the overall flux decrease level at the end of the storm recovery is less significant compared to that of the strong storm. However, the combined loss effect can still penetrate into r ∼ 5 RE, leading to some partial dropout of the flux. For the severe storm with Dstmin ≤ −150 nT, the flux dropout is far more significant than for the other two storms, indicating that the combined drift loss and Dst effect can even reduce the flux level at an inner region of r ∼ 4 RE. But in this case, the solar wind dynamic pressure is so high that the dayside magnetopause can cross the geosynchronous orbit. Consequently, the flux dropouts seen in actual observations can be primarily attributed to a fast and direct loss to the magnetopause at times when the magnetopause crosses the geosynchronous orbit. It is possible that our numerical results may quantitatively change to some extent with different magnetospheric models and assumptions and may also change depending on the validity of the fully adiabatic invariants assumption.
A 46-Year-Old Woman with a 4-Year History of Graves Disease, with Severe Corticosteroid-Unresponsive Thyroid Eye Disease, Successfully Treated with Tocilizumab

Patient: Female, 46-year-old Final Diagnosis: Graves’ disease Symptoms: Progressive exophthalmos • decreased vision • red and painful eyes • restriction of eye movements bilaterally Medication: Intravenous tocilizumab Clinical Procedure: — Specialty: Ophthalmology Objective: Unusual or unexpected effect of treatment Background: Tocilizumab is a therapeutic biologic antagonist of the interleukin-6 (IL-6) receptor that has been approved to treat some autoimmune and chronic inflammatory diseases. This report is of a patient with a history of Graves disease and severe corticosteroid-unresponsive thyroid eye disease that included edema of the optic nerve and choroid, which was successfully treated with tocilizumab. Case Report: A 46-year-old woman with a 4-year history of Graves disease presented with acutely progressive bilateral severe optic nerve compression, severe bilateral optic nerve edema, bilateral restriction of eye movement, and bilateral choroidal folds. The patient was managed with an initial high dose of systemic steroid without any success. She then underwent bilateral orbital wall decompression without any noticeable amelioration. She subsequently received 4 doses of a tocilizumab (8 mg/kg) infusion. This resulted in a considerable decrease in inflammatory signs and improvement in optic nerve function, thereby improving her quality of life. The patient did not have any adverse reactions to the tocilizumab. Conclusions: The findings from this case support recent case reports and clinical trials indicating that tocilizumab may be effective in corticosteroid-resistant thyroid eye disease associated with autoimmune hyperthyroidism.
Depression and Related Factors among Health Science Students in Da Nang, Vietnam: A Cross-Sectional Study

Background : This paper aimed to investigate the prevalence of depression and related factors among health science students in Da Nang, Vietnam. Method : A cross-sectional study was undertaken among 401 undergraduate students. Depression was measured using the Centre for Epidemiological Studies Short Depression Scale. Bivariate and multivariate logistic regression was applied to identify any associations. Results : Findings indicated that the prevalence of depression among students was 41.6%. Factors associated with the depression were studying in second year (aOR ¼ 3.15, 95%CI: 1.24 e 7.99), studying in third year (aOR ¼ 2.60, 95%CI: 1.056 e 6.42), poor health status (aOR ¼ 2.57, 95%CI: 1.54 e 4.29), low and moderate parents ’ relationships (aOR ¼ 12.41, 95%CI: 2.83 e 54.56 and aOR ¼ 5.71, 95%CI: 2.99 e 10.87) and high and moderate academic expectations (aOR ¼ 9.45, 95% CI: 4.13 e 21.66 and aOR ¼ 3.16, 95%CI: 1.68 e 5.95). Conclusion : Depression puts Vietnamese university students at risk of health and social problems. Prevention efforts are important to determine factors related to depression and prevent the consequence of those problems.
Biomonitoring of Indoor Air Fungal or Chemical Toxins with Caenorhabditis elegans nematodes

Bad indoor air quality due to toxins and other impurities can have a negative impact on human well-being, working capacity and health. Therefore, reliable methods to monitor the health risks associated with exposure to hazardous indoor air agents are needed. Here, we have used transgenic Caenorhabditis elegans nematode strains carrying stress-responsive fluorescent reporters and evaluated their ability to sense fungal or chemical toxins, especially those that are present in moisture-damaged buildings. Liquid-based or airborne exposure of nematodes to mycotoxins, chemical agents or damaged building materials reproducibly resulted in time- and dose-dependent fluorescent responses, which could be quantitated by either microscopy or spectrometry. Thus, the C. elegans nematodes present an easy, ethically acceptable and comprehensive in vivo model system to monitor the response of multicellular organisms to indoor air toxicity.
Analysis of Engineered Nanoparticles in Seawater Using ICP-MS-Based Technology: From Negative to Positive Samples

A growing global emission of engineered nanoparticles (ENPs) into the aquatic environment has become an emerging safety concern that requires methods capable of identifying the occurrence and possibly determining the amounts of ENPs. In this study, we employed sector-field inductively coupled mass spectrometry to assess the presence of ENPs in coastal seawater samples collected from the Black Sea in regions suffering different anthropogenic impacts. Ultrafiltration through commercial 3 kDa membrane filters was shown to be feasible to separate the ENPs from the bulk seawater, and the subsequent ultrasound-mediated acidic dissolution makes the metals constituting the ENPs amenable to analysis. This procedure allowed the ENPs bearing Cu, Zn, V, Mo, and Sn to be for the first time quantitated in seashore surface water, their concentration ranging from 0.1 to 1.0 μg L−1 (as metal) and related to the presence of industry and/or urban stress. While these levels are decreased by natural dilution and possible sedimentation, the monitored ENPs remain measurable at a distance of 2 km from the coast. This can be attributed not only to local emission sources but also to some natural backgrounds.
Use of Nanoparticles in Completion Fluids as Dual Effect Treatments for Well Stimulation and Clay Swelling Damage Inhibition: An Assessment of the Effect of Nanoparticle Chemical Nature

The objective of this study is to evaluate the role of nanoparticles with different chemical structures in completion fluids (CF) in providing a positive dual effect for well stimulation and clay swelling damage inhibition. Six types of commercial (C) or synthesized (S) nanoparticles have been incorporated into a commercial completion fluid. Doses varied between 100 and 500 mg·L−1. CF-nanoparticles were evaluated by fluid–fluid, fluid–nanoparticle, and fluid–rock interactions. The adsorption isotherms show different degrees of affinity, which impacts on the reduction of the interfacial tension between the CF and the reservoir fluids. Fluid–fluid interactions based on interfacial tension (IFT) measurements suggest that positively charged nanoparticles exhibit high IFT reductions. Based on contact angle measurements, fluid–rock interactions suggest that ZnO-S, SiO2-C, SiO2-S, and ZrO2 can adequately promote water–wet rock surfaces compared with other nanomaterials. According to the capillary number, ZnO-S and MgO-S have a higher capacity to reduce both interfacial and surface restrictions for crude oil production, suggesting that completion fluid with nanoparticles (NanoCF) can function as a stimulation agent. The clay swelling inhibition test in the presence of ZnO-S-CTAB and MgO-S-CTAB nanoparticles showed a 28.6% decrease in plastic viscosity (PV), indicating a reduction in clay swelling. The results indicate that a high-clay environment can meet the completion fluid’s requirements. They also indicate that the degree of clay swelling inhibition of the nanoparticles depends on their chemical nature and dosage. Finally, displacement tests revealed that CF with nanoparticles increased the oil linear displacement efficiency.
Modeling the Drop-Out Mechanism in Repeated-Measures Studies

Abstract Subjects often drop out of longitudinal studies prematurely, yielding unbalanced data with unequal numbers of measures for each subject. Modern software programs for handling unbalanced longitudinal data improve on methods that discard the incomplete cases by including all the data, but also yield biased inferences under plausible models for the drop-out process. This article discusses methods that simultaneously model the data and the drop-out process within a unified model-based framework. Models are classified into two broad classes—random-coefficient selection models and random-coefficient pattern-mixture models—depending on how the joint distribution of the data and drop-out mechanism is factored. Inference is likelihood-based, via maximum likelihood or Bayesian methods. A number of examples in the literature are placed in this framework, and possible extensions outlined. Data collection on the nature of the drop-out process is advocated to guide the choice of model. In cases where the drop-.
Advances in targeting of miR‑10‑associated lncRNAs/circRNAs for the management of cancer (Review)

With advancements in sequencing technologies, an increasing number of aberrantly expressed long-non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have been identified in various types of cancer. lncRNAs and circRNAs are now well-established tumor-influencing factors in cancer, driving not only tumor proliferation and invasion, but also cancer progression, drug resistance and metastatic recurrence. The majority of lncRNAs and circRNAs influence cancer progression by targeting microRNAs (miRNAs/miRs). miR-10a and miR-10b, key members of the miR-10 family, have been shown to play important regulatory roles in cell proliferation, differentiation to cancer progression, and development. Manual evaluation and grouping according to different types of competing endogenous RNA and tumor was performed. The review outlined the current state of knowledge on the regulation of miR-10 family-related lncRNAs and circRNAs. The involvement of lncRNAs and circRNAs in the biogenesis, maturation and function of malignant tumors through the miR-10 family, and the key gene targets and signaling cascades that lncRNAs and circRNAs regulate through the miR-10 family were summarized. Based on the findings of this review, it can be hypothesized that lncRNAs and circRNAs targeting the miR-10 family may serve as diagnostic/prognostic markers and/or therapeutic targets for the management of cancer.
Cluster coarsening in zinc oxide thin films by postgrowth annealing

Postgrowth annealing was carried out on ZnO thin films grown by metal-organic chemical-vapor deposition. It was found from the scanning electron microscopy and atomic force microscopy measurements that the morphology of the thin films changed drastically after annealing. The as-grown thin films consist of fine nanoscale-sized sheets with random orientation. Upon annealing at 800°C, the ZnO nanosheets changed to three-dimensional nanoneedles. The different types of the mass transport mechanisms are discussed and correlated with the experimental results. A coarsening kinetics developed by Lifshitz and Slyozov [J. Phys. Chem. Solids 19, 35 (1961)] and Wagner [Z. Elektrochem. 65, 581 (1961)] was used to estimate the activation energy of the coarsening process. The activation energy of the Ostwald ripening in ZnO films was estimated in the first attempt, and the value is at around 1.33eV. Hall effect and photoluminescence measurements were carried out to investigate the effect of coarsening on electrical and o.
Identification of Phytochemicals in Bioactive Extracts of Acacia saligna Growing in Australia

Acacia saligna growing in Australia has not been fully investigated for its bioactive phytochemicals. Sequential polarity-based extraction was employed to provide four different extracts from individual parts of A. saligna. Bioactive extracts were determined using in vitro antioxidant and yeast α-glucosidase inhibitory assays. Methanolic extracts from barks, leaves, and flowers are the most active and have no toxicity against 3T3-L1 adipocytes. Compound isolation of bioactive extracts provided us with ten compounds. Among them are two novel natural products; naringenin-7-O-α-L-arabinopyranoside 2 and (3S*,5S*)-3-hydroxy-5-(2-aminoethyl) dihydrofuran-2(3H)-one 9. D-(+)-pinitol 5a (from barks and flowers), (−)-pinitol 5b (exclusively from leaf), and 2,4-di-t-butylphenol 7 are known natural products and new to A. saligna. (−)-Epicatechin 6, quercitrin 4, and myricitrin 8 showed potent antioxidant activities consistently in DPPH and ABTS assays. (−)-Epicatechin 6 (IC50 = 63.58 μM), D-(+)-pinitol 5a (IC50 = 74.69 μM), and naringenin 1 (IC50 = 89.71 μM) are the strong inhibitors against the α-glucosidase enzyme. The presence of these compounds supports the activities exerted in our methanolic extracts. The presence of 2,4-di-t-butylphenol 7 may support the reported allelopathic and antifungal activities. The outcome of this study indicates the potential of Australian A. saligna as a rich source of bioactive compounds for drug discovery targeting type 2 diabetes.
Exploratory Model Study of Tornado-Like Vortex Dynamics

Abstract A laboratory model of the tornado-like vortex near the ground is developed and studied. The circulation is produced by a rotating cylindrical screen and the updraft is produced by an exhaust fan at the opening of the top hood. By means of kerosene smoke, the vortex core and a reverse flow zone were observed in the experiment. The profiles of velocity and pressure were measured at three different circulation strengths. The maximum inward radial velocity in the boundary layer is approximately proportional to the circulation strength. Outside the vortex core, the top hood and ground boundary layers, the flow is a potential vortex flow with a very small inward radial velocity. The vertical velocity distribution generally has a Gaussian profile except that it is slightly downward in the annular reverse flow region. The diameter of the reverse flow region is controlled by the opening size of the outlet on the top hood. The reverse flow region extends to the top of the ground boundary layer only when th.
Micro-Type III Radio Bursts

We present a detailed description of the features of solar "micro-type III" radio bursts, which are elements of the so-called type III storms, using long-term observations made by the Geotail and Akebono satellites. Micro-type III bursts are characterized by short-lived, continuous, and weak emission. Their average power is estimated to be well below that of the largest type III bursts, by 6 orders of magnitude. When they occur, these bursts have a distribution of emitted power flux that is different from that of ordinary type III bursts, indicating that they are not just weaker versions of the ordinary bursts. Micro-type III burst activity is not accompanied by significant solar soft X-ray activity. We identify the active regions responsible for micro-type III bursts by examining the concurrence of their development and decay with the bursts. It is found that both micro and ordinary type III bursts can emanate from the same active region without interference, indicating the coexistence of independent electron acceleration processes. It is suggested that the active regions responsible for micro-type III bursts generally border on coronal holes.