Miracle-dz/UniFAR-FTUs huggingface dataset:
Vitamin B12 Ameliorates Pesticide-Induced Sociability Impairment in Zebrafish (Danio rerio): A Prospective Controlled Intervention Study

Simple Summary Dietary vitamin supplementation is frequently mentioned as an alternative therapy for people with autism but is still controversial due to a lack of studies. The current study described a hypothetical real-life situation and evaluated the effect of vitamin B12 on the behavior of zebrafish. Vitamin-treated fish showed behavioral improvements after 14 days of daily exposure. In addition, the presence of the vitamin improved the redox state, leading to increased activity of antioxidant enzymes. Abstract Constant exposure to a variety of environmental factors has become increasingly problematic. A variety of illnesses are initiated or aided by the presence of certain perturbing factors. In the case of autism spectrum disorder, the environmental component plays an important part in determining the overall picture. Moreover, the lack of therapies to relieve existing symptoms complicates the fight against this condition. As a result, animal models have been used to make biomedical research easier and more suited for disease investigations. The current study used zebrafish as an animal model to mimic a real-life scenario: acute exposure to an increased dose of pesticides, followed by prospective intervention-based therapy with vitamin B12 (vit. B12). It is known that vit. B12 is involved in brain function nerve tissue, and red blood cell formation. Aside from this, the role of vit. B12 in the redox processes is recognized for its help against free radicals. To investigate the effect of vit. B12, fish were divided into four different groups and exposed to a pesticide mixture (600 μg L−1 fipronil + 600 μg L−1 pyriproxyfen) and 0.24 μg L−1 vit. B12 for 14 days. The impact of the compounds was assessed daily with EthoVision XT 11.5 software for behavioral observations, especially for sociability, quantified by the social interaction test. In addition, at the end of the study, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA) were measured. The results showed significant improvements in locomotor activity parameters and a positive influence of the vitamin on sociability. Regarding the state of oxidative stress, high activity was found for SOD and GPx in the case of vit. B12, while fish exposed to the mixture of pesticides and vit. B12 had a lower level of MDA. In conclusion, the study provides new data about the effect of vit. B12 in zebrafish, highlighting the potential use of vitamin supplementation to maintain and support the function of the organism.
Enhancement of Strawberry Shelf Life via a Multisystem Coating Based on Lippia graveolens Essential Oil Loaded in Polymeric Nanocapsules

Strawberries (Fragaria xannanasa) are susceptible to mechanical, physical, and physiological damage, which increases their incidence of rot during storage. Therefore, a method of protection is necessary in order to minimize quality losses. One way to achieve this is by applying polymer coatings. In this study, multisystem coatings were created based on polymer nanocapsules loaded with Lippia graveolens essential oil, and it was found to have excellent optical, mechanical, and water vapor barrier properties compared to the control (coating formed with alginate and with nanoparticles without the essential oil). As for the strawberries coated with the multisystem formed from the polymer nanocapsules loaded with the essential oil of Lippia graveolens, these did not present microbial growth and only had a loss of firmness of 17.02% after 10 days of storage compared to their initial value. This study demonstrated that the multisystem coating formed from the polymer nanocapsules loaded with the essential oil of Lippia graveolens could be a viable alternative to preserve horticultural products for longer storage periods.
Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation

Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), can manifest as long-term symptoms in multiple organ systems, including respiratory, cardiovascular, neurological, and metabolic systems. In patients with severe COVID-19, immune dysregulation is significant, and the relationship between metabolic regulation and immune response is of great interest in determining the pathophysiological mechanisms. We aimed to characterize the metabolomic footprint of recovering severe COVID-19 patients at three consecutive timepoints and compare metabolite levels to controls. Our findings add proof of dysregulated amino acid metabolism in the acute phase and dyslipidemia, glycoprotein level alterations, and energy metabolism disturbances in severe COVID-19 patients 3–4 months post-hospitalization.
The Effects of Soft Skills and Training Methodology on the Students’ Learning Performance and Graduate Employability in Jordan

Graduates with “soft skills” like teamwork and the ability to motivate others to achieve a common goal are in high demand from employers. Quantitative studies have not been undertaken in several nations; Hashemite kingdom of Jordan included. Investing in soft skills training is essential for creating a high-performance work culture. One approach that helps businesses attain a high-quality work culture is training. To be successful in today’s business world, you need a blend of hard and soft skills. The term “soft talents” is often used to refer to a wide range of qualities, such as self-awareness, the ability to take criticism without personal attack, and the capacity to get along well with others. The goals of this research are probed using quantitative methods. The research is cross-sectional in nature, with data obtained from 85 participants via the use of both descriptive and inferential statistical methods. Based on the results of the correlation and regression analysis, it was shown that the training technique has a 52% effect on graduates’ employability, while soft skills have a 58% effect on graduates’ employability on their own. The influence of soft skills on learning performance has been quantified at 64%, with the impact of training methods at 59%.
Convolutional Neural Network for Predicting Student
Academic Performance in Intelligent Tutoring System

: One of the most significant research areas in education and Artificial Intelligence (AI) is the earlier prediction of students’ academic achievement. Limited studies have been conducted using Deep Learning (DL) in the student domain of Intelligent Tutoring System (ITS). Traditional Machine Learning (ML) techniques have been employed in many earlier publications to predict student performance. This paper investigates the e ff ectiveness of DL algorithms for predicting student academic performance. Three di ff erent DL architectures based on the structure of Convolutional Neural Networks (CNN) are presented. Two public datasets are used. Furthermore, two feature selection techniques are utilized in this experiment: Principal Component Analysis (PCA) and Decision Trees (DTs). Also, we applied a resampling technique for the first dataset to address the issue of an imbalanced dataset. According to the experimental findings, the proposed CNN model’s success in predicting student performance at early stages reached an accuracy of 94.36% using the first dataset and 84.83% using the second dataset. Comparing the proposed approach with the previous studies, the proposed approach outperformed all previous studies when dataset 2 and part of dataset 1 were used. For the complete dataset 1, the proposed model performed very well.
Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes

Omentin is an adipokine mainly produced by visceral fat tissue. It has two isoforms, omentin-1 and omentin-2. Omentin-1 is predominantly secreted by visceral adipose tissue, derived specifically from the stromal vascular fraction cells of white adipose tissue (WAT). Levels of omentin-1 are also expressed in other WAT depots, such as epicardial adipose tissue. Omentin-1 exerts several beneficial effects in glucose homeostasis in obesity and diabetes. In addition, research has suggested that omentin-1 may have atheroprotective (protective against the development of atherosclerosis) and anti-inflammatory effects, potentially contributing to cardiovascular health. This review highlights the potential therapeutic targets of omentin-1 in metabolic disorders.
Fractional optimal control analysis of Covid-19 and dengue fever co-infection model with Atangana-Baleanu derivative

A co-infection with Covid-19 and dengue fever has had worse outcomes due to high mortality rates and longer stays either in isolation or at hospitals. This poses a great threat to a country's economy. To effectively deal with these threats, comprehensive approaches to prevent and control Covid-19/dengue fever co-infections are desperately needed. Thus, our focus is to formulate a new co-infection fractional model with the Atangana-Baleanu derivative to suggest effective and feasible approaches to restrict the spread of co-infection. In the first part of this paper, we present Covid-19 and dengue fever sub-models, as well as the co-infection model that is locally asymptotically stable when the respective reproduction numbers are less than unity. We establish the existence and uniqueness results for the solutions of the co-infection model. We extend the model to include a vaccination compartment for the Covid-19 vaccine to susceptible individuals and a treatment compartment to treat dengue-infected individuals as optimal control strategies for disease control. We outline the fundamental requirements for the fractional optimal control problem and illustrate the optimality system for the co-infection model using Pontraygin's principle. We implement the Toufik-Atangana approximating scheme to simulate the optimality system. The simulations show the effectiveness of the implemented strategy in determining optimal vaccination and treatment rates that decrease the cost functional to a minimum, thus significantly decreasing the number of infected humans and vectors. Additionally, we visualize a meaningful decrease in infection cases with an increase in the memory index. The findings of this study will provide reasonable disease control suggestions to regions facing Covid-19 and dengue fever co-infection.
GENETIC ANALYSIS OF GROWTH AND SOME REPRODUCTIVE TRAITS OF SHEEP OF NORTHERN NIGERIA AND THEIR CROSSES

A THESIS SUBMITTED TO POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA. IN PARTIAL FULFILMENT FOR THE AWARD OF MASTERS OF SCIENCE IN THE DEPARTMENT OF ANIMAL SCIENCE AHMADU BELLO UNIVERSITY, ZARIA NIGERIA SEPTEMBER 2012
Application of Immune Checkpoint Inhibitors in Advanced Melanoma

The advent of ICIs has significantly improved outcomes for many types of cancer treatment, including advanced melanoma that cannot be respected. Among melanoma patients, there is clear evidence that Ipilimumab, the first monoclonal antibody approved for CTLA-4 targeting, as well as nivolumab and pembrolizumab, which concentrate on PD-1, have led to increased overall survival. Combination therapy with other therapies shows better efficacy with ICI compared to monotherapy (e.g., a combination of CTLA-4 and PD-1 inhibitors). This article will explore recent research on the therapies of advanced melanoma, investigate the pathways of CTLA-4 and PD-1/PD-L1 and their application as single therapy or combination with other therapies such as PD-1 drugs, in addition to other therapeutic methods, and the current application of TCM treatment. In addition, this review will discuss drug resistance to ICI treatment and explore potential biomarkers associated with ICI response in advanced melanoma patients and future prospects for ICI treatment.
Primate: A Framework to Automatically Generate Soft Processors for Network Applications

Overlay processors on FPGAs enable i) software programmability through sequential code calling library functions, ii) high performance by converting the library calls to invocations of corresponding accelerators, and iii) faster deployment than reprogramming the FPGA. Traditionally, overlays have been hand-written in RTL and programmed through handwritten assembly. We present the Primate framework, which automatically generates overlays from applications written in annotated C++. We evaluated Primate on Whippersnapper (Dang et al. 2017) P4 benchmarks. Primate Overlay latencies are 0.06x - 0.15x compared to PISCES (Shahbaz et al. 2016), a high-performance CPU solution, and 0.25x - 2.3x compared to solutions generated by P4FPGA (Wang et al. 2017), a P4 HLS compiler on FPGA.
Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy

Background Diabetic Nephropathy (DN) is one of the microvascular complications of diabetes. The potential targets of renin-angiotensin-aldosterone system (RAAS) inhibitors for the treatment of DN need to be explored. Methods The GSE96804 and GSE1009 datasets, 729 RAAS inhibitors-related targets and 6,039 DN-related genes were derived from the public database and overlapped with the differentially expressed genes (DN vs. normal) in GSE96804 to obtain the candidate targets. Next, key targets were screened via the Mendelian randomization analysis and expression analysis. The diagnostic nomogram was constructed and assessed in GSE96804. Additionally, enrichment analysis was conducted and a ‘core active ingredient-key target-disease pathway’ network was established. Finally, molecular docking was performed. Results In total, 60 candidate targets were derived, in which CTSC and PDE5A were screened as the key targets and had a causal association with DN as the protective factors (P < 0.05, OR < 1). Further, a nomogram exhibited pretty prediction efficiency. It is indicated that Benadryl hydrochloride might play a role in the DN by affecting the pathways of ‘cytokine cytokine receptor interaction’, etc. targeting the CTSC. Moreover, PDE5A might be involved in ‘ECM receptor interaction’, etc. for the effect of NSAID, captopril, chlordiazepoxide on DN. Molecular docking analysis showed a good binding ability of benadryl hydrochloride and CTSC, NSAID and PDE5A. PTGS2, ITGA4, and ANPEP are causally associated with acute kidney injury. Conclusion CTSC and PDE5A were identified as key targets for RAAS inhibitors in the treatment of DN, which might provide some clinical significance in helping to diagnose and treat DN. Among the targets of RAAS inhibitors, PTGS2, ITGA4 and ANPEP have a causal relationship with acute kidney injury, which is worthy of further clinical research.
Broadening the Scope of Bone Anvils: Direct AMS 14C Dating from the Island of Menorca (Western Mediterranean)

Abstract This article presents the results of direct accelerator mass spectrometry (AMS) radiocarbon dating of a new bone anvil retrieved in the Iron Age–Roman site of Montefí (Ciutadella), in the southwest of the island of Menorca (western Mediterranean). The radiometric date confirms the chronology obtained through the stratigraphy and typological analysis of ceramics (1st–3rd century AD), and indicates that this bone-made tool not only represents the first archaeological anvil from the island but also constitutes the earliest evidence in the western Mediterranean. This ancient date is more consistent with the known eastern regional chronology and reinforces the importance of obtaining direct AMS 14C dates to refine artifact chronologies.
Inactivation of antibiotic-resistant bacteria Escherichia coli by electroporation

Introduction In modern times, bacterial infections have become a growing problem in the medical community due to the emergence of antibiotic-resistant bacteria. In fact, the overuse and improper disposal of antibiotics have led to bacterial resistance and the presence of such bacteria in wastewater. Therefore, it is critical to develop effective strategies for dealing with antibiotic-resistant bacteria in wastewater. Electroporation has been found to be one of the most promising complementary techniques for bacterial inactivation because it is effective against a wide range of bacteria, is non-chemical and is highly optimizable. Many studies have demonstrated electroporation-assisted inactivation of bacteria, but rarely have clinical antibiotics or bacteria resistant to these antibiotics been used in the study. Therefore, the motivation for our study was to use a treatment regimen that combines antibiotics and electroporation to inactivate antibiotic-resistant bacteria. Methods We separately combined two antibiotics (tetracycline and chloramphenicol) to which the bacteria are resistant (with a different resistance mode) and electric pulses. We used three different concentrations of antibiotics (40, 80 and 150 µg/ml for tetracycline and 100, 500 and 2000 µg/ml for chloramphenicol, respectively) and four different electric field strengths (5, 10, 15 and 20 kV/cm) for electroporation. Results and discussion Our results show that electroporation effectively enhances the effect of antibiotics and inactivates antibiotic-resistant bacteria. The inactivation rate for tetracycline or chloramphenicol was found to be different and to increase with the strength of the pulsed electric field and/or the concentration of the antibiotic. In addition, we show that electroporation has a longer lasting effect (up to 24 hours), making bacteria vulnerable for a considerable time. The present work provides new insights into the use of electroporation to inactivate antibiotic-resistant bacteria in the aquatic environment.
Nailfold Capillaroscopy Analysis Can Add a New Perspective to Biomarker Research in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), all of which are characterised by inflammation of small–medium-sized vessels. Progressive understanding of these diseases has allowed researchers and clinicians to start discussing nailfold video capillaroscopy (NVC) as a future tool for many applications in daily practice. Today, NVC plays a well-established and validated role in differentiating primary from secondary Raynaud’s phenomenon correlated with scleroderma. Nevertheless, there has not been sufficient attention paid to its real potential in the ANCA-associated vasculitis. In fact, the role of NVC in vasculitis has never been defined and studied in a multicentre and multinational study. In this review, we carried out a literature analysis to identify and synthesise the possible role of capillaroscopy for patients with ANCA-associated vasculitis. Methods: Critical research was performed in the electronic archive (PUBMED, UpToDate, Google Scholar, ResearchGate), supplemented with manual research. We searched in these databases for articles published until November 2023. The following search words were searched in the databases in all possible combinations: capillaroscopy, video capillaroscopy, nailfold-video capillaroscopy, ANCA-associated vasculitis, vasculitis, granulomatosis with polyangiitis, EGPA, and microscopic polyangiitis. Results: The search identified 102 unique search results. After the evaluation, eight articles were selected for further study. The literature reported that capillaroscopy investigations documented non-specific abnormalities in 70–80% of AAV patients. Several patients showed neoangiogenesis, capillary loss, microhaemorrhages, and bushy and enlarged capillaries as the most frequent findings. Furthermore, the difference between active phase and non-active phase in AAV patients was clearly discernible. The non-active phase showed similar rates of capillaroscopy alterations compared to the healthy subjects, but the active phase had higher rates in almost all common abnormalities instead. Conclusions: Microvascular nailfold changes, observed in patients affected by vasculitis, may correlate with the outcome of these patients. However, these non-specific abnormalities may help in the diagnosis of vasculitis. As such, new analysis analyses are necessary to confirm our results.
Remote field-programmable gate array laboratory for signal acquisition and design verification

A remote laboratory utilizing field-programmable gate array (FPGA) technologies enhances students’ learning experience anywhere and anytime in embedded system design. Existing remote laboratories prioritize hardware access and visual feedback for observing board behavior after programming, neglecting comprehensive debugging tools to resolve errors that require internal signal acquisition. This paper proposes a novel remote embedded-system design approach targeting FPGA technologies that are fully interactive via a web-based platform. Our solution provides FPGA board access and debugging capabilities beyond the visual feedback provided by existing remote laboratories. We implemented a lab module that allows users to seamlessly incorporate into their FPGA design. The module minimizes hardware resource utilization while enabling the acquisition of a large number of data samples from the signal during the experiments by adaptively compressing the signal prior to data transmission. The results demonstrate an average compression ratio of 2.90 across three benchmark signals, indicating efficient signal acquisition and effective debugging and analysis. This method allows users to acquire more data samples than conventional methods. The proposed lab allows students to remotely test and debug their designs, bridging the gap between theory and practice in embedded system design.
COVID-19 Vaccination Coverage and Associated Factors in Patients with Multiple Sclerosis

Our objective was to know the COVID-19 vaccination coverage in multiple sclerosis (MS) patients and its factors associated. A retrospective cohort study was carried out. Patients seen at the MS unit of the University Clinical Hospital of Zaragoza between 2017 and 2021 were included. Variables were obtained by reviewing the specialized and primary care records. Associations between receiving COVID-19 full primo-vaccination, as well as one booster dose since autumn 2022, and the other variables were analyzed using bivariate analysis and multiple logistic regression models. Of the 359 included patients, 90.3% received the COVID-19 full primo-vaccination. Having been born in Spain (aOR = 3.40) and having received the 2020–2021 influenza vaccine (aOR = 6.77) were associated with receiving the COVID-19 full primo-vaccination. Vaccination with a COVID-19 booster dose was detected in 141 patients (39.3%). Sex (man) (aOR = 2.36), age (60 years or over) (aOR = 6.82), type of MS (Primary Progressive/Secondary Progressive) (aOR = 3.94), and having received the 2022–2023 influenza vaccine (aOR = 27.54) were associated with receiving such a booster dose. The COVID-19 booster dose was administered at the same time as the 2022–2023 influenza vaccine in 57.8% (67/116) of the patients vaccinated with both vaccines. The COVID-19 full primo-vaccination coverage is higher than in other countries. However, the decrease in vaccination coverage with the booster dose makes it necessary to develop strategies to improve it that are not limited to administering the flu vaccine together with the COVID-19 booster dose. Such strategies should be in focus, especially for women under 60 years of age.