Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Outcomes for Non-ST Elevation Acute Myocardial Infarction in Weekday vs Weekend Admissions: The Weekend Effect

Background Recent literature shows that reduced staffing over the weekends in hospitals may compromise patient care with acute conditions like acute coronary syndrome (ACS). Objective Our study evaluated differences in the outcomes between patients presenting with non-ST segment elevation acute coronary syndrome (NSTE-ACS) on weekends versus those coming on weekdays. Methods A single-center retrospective study was performed on NSTE-ACS patients. Data were analyzed using SPSS version 22 to calculate an independent sample t-test value for significance between the two groups. Results The mean DTB time for patients admitted over the weekend was significantly higher than those admitted over weekdays (p = 0.000). The mean peak troponin level and length of stay (LOS) for patients admitted over the weekends vs. weekdays was significantly higher by 5 ng/dL (9.71 ± 5.23 vs. 4.194 ± 2.60, p = 0.0001) and 24 h (72 ± 10 vs. 48 ± 6 h, p = 0.003), respectively. While the mean left ventricular ejection fraction (EF) of patients on discharge was lower by 5% for patients admitted over the weekend compared to patients admitted on weekdays (p = 0.001). Conclusion NSTE-ACS patients admitted over the weekends have a significantly higher myocardial injury evidenced by an increased LOS, higher peak troponin levels, and reduced EF due to delayed PCI compared to weekday admissions.
Hypertension: Prevalence in a Nigerian Adult Population

: Background: Hypertension, one of the non communicable diseases of public interest is affecting adults globally with increasing prevalence ravaging adults in developing countries especially in Africa. Hypertension, according to reports has high prevalence, low control rate and cardiovascular complications. Prevalence of hypertension is high in Nigeria and the overall awareness of raised blood pressure among hypertension cases is low in the country. The aim of this study was to evaluate the prevalence of hypertension in undiagnosed adults in Warri metropolis in a developing country of Nigeria. Methods: Total of 420 adults comprising 210 males and 210 females randomly selected across Warri metropolis aged 21-85years were recruited to participate in the study. Blood Pressure was measured using automated digital Sphygmomanometer according to standard method. The results were categorized according to World Health Organization Blood Pressure chart. Results: Total of 42.2% of the population was observed with systolic high blood pressure while 47.1% and 29.1%of the male and female populations were observed with systolic high blood respectively. About 15.0% of the total population was observed with diastolic high blood pressure. Conclusion: Need for both government and non-governmental organizations to increase public health education to increase awareness campaigns for regular community based monitoring of high blood pressure because of the associated risk factors is necessary.
On the influence of Variscan inheritance on rifting of the Western Iberian margin

The passive margin of Western Iberia (WIM) developed during the Mesozoic over the pre‐existing Variscan Orogen. In the present study we use integrated interpretation and modelling to understand the distribution of Variscan basement provinces in the offshore of Iberia. The NW–SE trending fabric of the Variscan Orogen can be recognized in the WIM, and different Variscan basement provinces behaved differently during extension. Furthermore, major Variscan structures reactivated in extension, compartmentalizing rifting and having a major impact on the final architecture of the WIM.
Patterns of Prescription Medicine, Illicit Drugs, and Alcohol Misuse among High-Risk Population: A Factor Analysis to Delineate Profiles of Polydrug Users

Polydrug use is a serious health and social problem worldwide. Treatment remains a challenge because it requires planning based on estimates of the nature and extent of drug consumption and the characteristics of the population in need. To this end, 103 subjects, who voluntarily asked to begin rehabilitation treatment, were monitored through hair analysis to investigate the nature and extent of their polydrug use. A factor analysis was carried out to delineate polydrug user profiles based on the following variables: age, sex, type of illicit drug use, type of prescription drug misuse, and amount of alcohol consumption. Twenty-three percent of subjects tested positive to more than one illicit drug (mainly cocaine), 44% to unprescribed drugs (mainly benzodiazepines), and 66% were hard drinkers. The profiles of drug users outlined included “single drug cocaine user”, and “single drug opiate user”. Moreover, a particularly problematic profile of cocaine users, common between genders and age groups, who combine high levels of alcohol and unprescribed benzodiazepines and opiates, emerged (“hard polydrug abusers”). From a treatment policy perspective, these findings support the importance of preventive analysis before rehabilitation treatment begins in order to identify different patterns of drug abusers to implement personalized multidisciplinary measures.
18S rDNA amplicon sequence data (V1–V3) of the Palmyra Atoll National Wildlife Refuge, Central Pacific

To address the global biodiversity crisis, standardized data that are rapidly obtainable through minimally invasive means are needed for documenting change and informing conservation within threatened and diverse systems, such as coral reefs. In this data paper, we describe 18S rRNA gene amplicon data (V1–V3 region) generated from samples collected to begin characterizing coral reef eukaryotic community composition at the Palmyra Atoll National Wildlife Refuge in the Central Pacific Ocean. Sixteen samples were obtained across four sample types: sediments from two sieved fractions (100–500 μm, n = 3; 500 μm-2 mm, n = 3) and sessile material scrapings (n = 3) from Autonomous Reef Monitoring Structures (ARMS) sampled in 2015, as well as seawater from 2012 (n = 7). After filtering and contaminant removal, 3,861 Amplicon Sequence Variants (ASVs) were produced from 1,062,238 reads. The rarefaction curves demonstrated adequate sampling depth, and communities grouped by sample type. The dominant orders across samples were polychaete worms (Eunicida), demosponges (Poecilosclerida), and bryozoans (Cheilostomatida). The ten most common orders in terms of relative abundance comprised ~60% of all sequences and 23% of ASVs, and included reef-building crustose coralline algae (CCA; Corallinophycidae) and stony corals (Scleractinia), two taxa associated with healthy reefs. Highlighting the need for further study, ~21% of the ASVs were identified as uncultured, incertae sedis , or not assigned to phylum or order. This data paper presents the first 18S rDNA survey at Palmyra Atoll and serves as a baseline for biodiversity assessment, monitoring, and conservation of this remote and pristine ecosystem.
Functional Dissection of P1 Bacteriophage Holin-like Proteins Reveals the Biological Sense of P1 Lytic System Complexity

P1 is a model temperate myovirus. It infects different Enterobacteriaceae and can develop lytically or form lysogens. Only some P1 adaptation strategies to propagate in different hosts are known. An atypical feature of P1 is the number and organization of cell lysis-associated genes. In addition to SAR-endolysin Lyz, holin LydA, and antiholin LydB, P1 encodes other predicted holins, LydC and LydD. LydD is encoded by the same operon as Lyz, LydA and LydB are encoded by an unlinked operon, and LydC is encoded by an operon preceding the lydA gene. By analyzing the phenotypes of P1 mutants in known or predicted holin genes, we show that all the products of these genes cooperate with the P1 SAR-endolysin in cell lysis and that LydD is a pinholin. The contributions of holins/pinholins to cell lysis by P1 appear to vary depending on the host of P1 and the bacterial growth conditions. The pattern of morphological transitions characteristic of SAR-endolysin–pinholin action dominates during lysis by wild-type P1, but in the case of lydC lydD mutant it changes to that characteristic of classical endolysin-pinholin action. We postulate that the complex lytic system facilitates P1 adaptation to various hosts and their growth conditions.
Challenges in Menstrual Hygiene Practices among Urban and Rural Women (Aged 15-45 Years) of District Pali in Western Rajasthan

Introduction: In India, even today regressive socio-cultural norms pertaining to menstruation continue to thrive in many parts. The government in Rajasthan has been distributing sanitary napkins to girls in the age group 10-19 years through the Education & ICDS department since 2018. This study assesses utilization and acceptance of the sanitary pads distributed frees of cost among adolescents and at a nominal rate to women and identifies the challenges in observing menstrual hygiene practices in semi arid areas. Method: A cross-sectional study was conducted among women aged 15-45 years in six urban wards and six sub- centre villages under the Rural Health and training Centre(RHTC) Gundoj. Keeping power of study at 80% adding the 10% non-response, 50% prevalence for hygienic menstrual practices, a sample size of 384 participants was taken, 192 each from rural and urban areas with 50% of the participants being school going girls. Results: Among school going participants 184 ( 95.8%) in urban areas and 169(88%) were utilizing the free sanitary pads distributed in schools, rest used locally purchased “red cloth”. Average level of hygiene practices was comparatively more among urban participants 173(90%) than rural women 77(40.1%) (p value<0.05). During menstruation performing religious activities, doing idol worship, eating and drinking water with family was taboo among 92% of both urban and rural respondents. Conclusion: Distribution of sanitary pads in schools is a successful intervention in Pali District. However, knowledge of healthy menstrual hygiene practices was low (23%) among rural women. Disposal of used pads and attitude towards social taboos need to be addressed in the rural areas of the district with better convergence between Education, ICDS and Health department for advocacy of healthy menstrual hygiene practices.
Occupational safety in a globalized construction industry: a study on Polish workers in Norway*

Abstract Polish workers are the largest group of migrant workers in Norway and are particularly well represented in the construction industry. According to several studies, migrant workers are more prone to occupational accidents than the native workers are. This difference is often attributed to poor communication and lack of linguistic skills. We explored factors affecting occupational safety related to migrant workers with an emphasis on communication, culture and language through interviews with Polish and Norwegian workers. The study shows that the construction industry in Norway mainly focuses on language as an issue. Culture is seen as a contributing factor, but is somewhat neglected. Fewer measures to cope with challenges related to migrant workers were found for cultural issues as compared to linguistic. However, the study shows that cultural aspects are at least as important. This gives implications for safety management in the construction industry. This paper suggests considering cultural aspects more in safety management related to migrant workers to achieve the desired safety focus at construction sites.
Microstructural and Physicochemical Analysis of Collagens from the Skin of Lizardfish (Saurida tumbil Bloch, 1795) Extracted with Different Organic Acids

Marine fish collagen has attracted considerable attention due to its characteristics, including its biodegradability, biocompatibility, and weak antigenicity, and is considered a safer material compared to collagen from terrestrial animals. The aim of this study was to extract and characterize collagen from the skin of lizardfish (Saurida tumbil Bloch, 1795) with three different acids. The yields of acetic acid-extracted collagen (AESkC), lactic acid-extracted collagen (LESkC), and citric acid-extracted collagen (CESkC) were 11.73 ± 1.14%, 11.63 ± 1.10%, and 11.39 ± 1.05% (based on wet weight), respectively. All extracted collagens were categorized as type I collagen with mainly alpha chains (α1 and α2) detected and γ and β chains to some extent. Fourier transform infrared (FTIR) spectra showed an intact triple-helical structure in the AESkC, LESkC, and CESkC. UV-vis spectra and X-ray diffraction further demonstrated the similarity of the extracted collagens to previously reported fish skin collagens. AESkC (Tmax = 40.24 °C) had higher thermostability compared to LESkC (Tmax = 38.72 °C) and CESkC (Tmax = 36.74 °C). All samples were highly soluble in acidic pH and low concentrations of NaCl (0–20 g/L). Under field emission scanning electron microscopy (FESEM) observation, we noted the loose, fibrous, and porous structures of the collagens. The results suggest that the lizardfish skin collagens could be a potential alternative source of collagen, especially the AESkC due to its greater thermostability characteristic.
Modelling the Roles of Community-Based Organisations in Post-Disaster Transformative Adaptation

Disasters result where hazards and vulnerabilities intersect. The concept of vulnerability itself is mainly a social construct and the extent to which this can be overcome while transforming disaster-prone systems has often been emphasised in the critical hazard literature. However, the extent to which community-based organisations contribute to post-disaster transformation at the community level remains unexamined. This paper is aimed at examining the extent of the role of community-based organisations (CBOs) in the transformative adaptation of post-earthquake Lyttelton. Quantitative data was obtained from community members using a questionnaire survey of 107 respondents, supporting interviews, and secondary data to explain the phenomenon in this study. System dynamics and agent-based modelling tools were applied to analyse the data. The results show that while CBOs played a major role in Lyttelton’s transformation by fostering collaboration, innovation, and awareness, the extent of their impact was determined by differences in their adaptive capacities. The transformation was influenced by the impacts of community initiatives that were immediate, during, and a long time after the disaster recovery activities in the community. Our research extends the discourse on the role of community-based organisations in disaster recovery by highlighting the extent of CBOs’ impacts in community post-disaster transformation.
Risk of Burning Mouth Syndrome in Patients with Migraine: A Nationwide Cohort Study

Migraine is a common neurological disease that causes a variety of symptoms, most notably throbbing, which is described as a pulsing headache on one side of the head. Burning mouth syndrome (BMS) is defined as an intra-oral burning sensation. Currently, no medical or dental cause has been identified for BMS. Interestingly, neuropathic pain is a characteristic feature of BMS; however, it remains unclear whether migraine can cause BMS. We aimed to identify the association of migraine with the risk of developing BMS. We used a representative nationwide cohort sample of approximately 1 million patients from 2002 to 2013 to investigate the prospective association between migraine and BMS. A total of 4157 migraine patients (migraine group) and 16,628 patients without migraine (comparison group) were enrolled after 1:4 propensity score matching. The overall incidence of BMS was significantly higher in the migraine group (0.15 per 1000 person-years) than in the comparison group (0.05 per 1000 person-years). The adjusted HR for patients with migraine who reported BMS events during the 10-year follow-up period was 2.96 (95% confidence interval, 1.02–8.56), after adjusting for other covariates. However, in the subgroup analysis, the adjusted HR for BMS events did not show a significant difference between the migraine and comparison group according to sex, age, and comorbidities. This study suggests that migraine is associated with an increased incidence of BMS. Therefore, clinicians should be attentive to detect BMS at an early stage when treating patients with migraine.
Effects of surface modification techniques on zirconia substrates and their effect on bonding to dual cure resin cement - An in- vitro study

Aim: This study aims to evaluate the effect of different surface treatments of monolithic zirconia on the bond strength of resin to zirconia and, to explore alternative methods to improve this bonding. Settings and Design: In-Vitro study. Materials and Methods: Fifty rectangular sintered blocks of Yttria-stabilized Tetragonal Zirconia Polycrystal ceramics of dimensions were milled and sintered. These specimens were further divided into five groups (control, air abrasion, etching with primer application, air abrasion with primer application and novel glass infiltrated zirconia surface group), containing 10 samples each. The specimens were analyzed for surface roughness, tensile bond strength to resin cements, and adhesive and cohesive mode of failures. Statistical Analysis Used: ANOVA and Post-Hoc Tukey test was perform to evaluate the significant differences in the mean values of the groups. Results: Air-abraded samples showed the highest surface roughness (4.95 ± 0.65) (P < 0.05). The group with air abrasion followed by primer application showed the highest tensile bond strength (7.12 ± 0.69) (P < 0.05). The lowest surface roughness (0.638 ± 0.8093) and tensile bond strength (2.03 ± 0.58) was seen in samples that were subjected to etchant treatment followed by application of methacryloyloxydecyl di-hydrogen phosphate (MDP) primer. The changes in comparison to the control group were statistically insignificant (P > 0.05). Except Groups A (control) and C (etchant followed by primer), all other groups showed a cohesive failure. Conclusion: Air abrasion of the zirconia surface with 50 μm alumina particles increases the surface roughness without damaging the surface. Air abrasion followed by MDP primer application is the recommended method of surface treatment to achieve superior bonding. Glass infiltration also showed promising results in terms of tensile bond strength.
Capsanthin-Loaded Micelles: Preparation, Characterization and in vitro Evaluation of Cytotoxicity Using MDA-MB-231 Breast Cancer Cell Line

SUMMARY Research background Breast cancer is one of the most common cancers and remains a major cause of morbidity and mortality among women worldwide. In developed countries, breast cancer as a multifactorial disease is a major health concern, and its incidence is constantly rising in low and middle-income countries. Numerous studies have demonstrated that phytochemicals such as carotenoids inhibit breast cancer growth and induce apoptosis. We recently enhanced the solubility of capsanthin in water by encapsulating it in diosgenin polyethylene glycol succinate, a novel non-ionic surfactant. Thus, this study aims to evaluate the cytotoxicity of water-soluble capsanthin-loaded micelles in MDA-MB-231 cells in vitro through tetrazolium dye MTT assay. Experimental approach In the current study, capsanthin, a hydrophobic carotenoid, is extracted from sweet red pepper (Capsicum annuum). Capsanthin-loaded diosgenin polyethylene glycol succinate 1000 (cap-DPGS-1000) micelles were prepared from capsanthin extract (cap) and diosgenin polyethylene glycol succinate 1000 (DPGS-1000) using the solid dispersion method. The capsanthin extract and cap-DPGS-1000 micelles were characterized by UV-visible spectroscopy, high-performance liquid chromatography (HPLC), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), particle size distribution, polydispersity, and scanning electron microscopy (SEM). The effects of capsanthin extract and cap-DPGS-1000 micelles on a human triple-negative breast cancer cell line (MDA-MB-231) were tested to check the cell viability, proliferation and cytotoxicity of the micelles. Results and conclusions The solubility of encapsulated cap-DPGS-1000 micelles in water is greatly enhanced and leads to an increased scope for localized drug delivery, a better delivery option for treating residual cancerous tumours. The encapsulated capsanthin showed a sustained release in simulated intestinal fluid (pH=6.8). Our research proposes a sustained drug delivery system that ensures effective and controlled release to the affected site. The characterization data revealed no change in the structure and functional groups in the encapsulated capsanthin. The IC50 value of the cap-DPGS-1000 micelles against MDA-MB-231 breast cancer cells was (3.10±1.09) μg/mL, which is much lower than of capsanthin extract ((81.1±1.5) μg/mL). Capsanthin extract and capsanthin-loaded micelles are promising drug candidates to induce apoptosis and increase reactive oxygen species (ROS) in cancer cells. Novelty and scientific contribution The result shows the cytotoxic effect of capsanthin and capsanthin-loaded micelles on MDA-MB-231 cell line for the first time. Capsanthin from sweet red pepper (Capsicum annuum) showed remarkable cytotoxic effect on the triple-negative MDA-MB-231 cell line.
New and little-known species of the genus Dicerapanorpa from northwestern Yunnan, China (Mecoptera: Panorpidae)

The genus Dicerapanorpa Zhong & Hua, 2013 previously comprised 20 known species that are endemic to central and southwestern China. Herein, I present new knowledge of this genus from northwestern Yunnan, including descriptions of four new species, Dicerapanorpa harmonia sp. nov., Dicerapanorpa huangguocongi sp. nov., Dicerapanorpa nakhi sp. nov., and Dicerapanorpa yangqichengi sp. nov. In addition, three little-known species, Dicerapanorpa tenuis Hu, Wang & Hua, 2019, Dicerapanorpa tjederi Carpenter, 1938, and Dicerapanorpa triclada (Qian & Zhou, 2001) are redescribed and illustrated based on new materials. An updated key to all known 24 species of Dicerapanorpa is provided, and a distributional map of Dicerapanorpa species from Yunnan is presented. The evolution and biology of Dicerapanorpa are briefly discussed.
Capital Structure and Financial Performance of Listed Pharmaceutical Companies in Nigeria

This study investigated the relationship between capital structure and financial performance of listed pharmaceutical companies in Nigeria from 2013–2017. The ex post facto research design was adopted for the study with a population of ten (10) listed pharmaceutical companies in Nigeria as listed by the Nigerian Exchange Group in 2021. Data were retrieved from the annual reports of the selected listed pharmaceutical companies for the period 2013–2017. Multiple regression analysis was used to analyze the data gathered with the aid of Stata12 statistical software. The study revealed a positive and significant relationship between equity capital and profit before tax of listed pharmaceutical companies in Nigeria. It also revealed the existence of a positive and significant relationship between equity capital and return on assets of listed pharmaceutical companies in Nigeria. Therefore, it was recommended that the management of listed pharmaceutical companies in Nigeria should pay more attention to equity capital because it is a major determinant in enhancing profit before tax, and that equity capital should be encouraged so as to boast return of assets of listed pharmaceutical companies in Nigeria.
Wave Reflection and Transmission for Submerged Monolithic Breakwaters

A linear wave model based on the hyperbolic type mild slope equations is adapted to incorporate the effects of a monolithic submerged breakwater. The presence of the structure is simply introduced into the existing model as a stepwise variation of the water depth. For the energy dissipation due to the flow separation a simple hydraulic loss formula is derived. The effectiveness of the breakwater in damping the incident wave energy is measured in terms of the resulting transmission coefficients. The calculated coefficients are compared with experimental data.