Miracle-dz/UniFAR-FTUs huggingface dataset:
A New Filter Cassette for the Direct Microscopic Examination of Airborne Fungal Spores

The study describes a 25-mm filter cassette constructed with a plastic masking disk covering the bottom of the cassette cowl, reducing the area of exposed filter by 95%. Two rectangular sample traces, each with a size of 1.7 mm × 5.5 mm (9.35 mm2) were produced. The traces were sufficiently small to be analyzed by direct microscopic examination without requiring a sample transfer step. Direct microscopy of fungal spores using the new Bi-Air (BA) filter cassette was compared to the Air-O-Cell (AOC) slit impaction cassette using Penicillium chrysogenum and Stachybotrys chartarum spores. The comparisons involved the collection of side-by-side samples in a quiescent settling chamber. The distribution of P. chrysogenum and S. chartarum spores between the duplicate BA sample traces was uniform. The deposition of spores across the sample traces was also similar for the BA and AOC, with a coefficient of variation (CV) between traverses of 27% for the BA and 29% for the AOC. The average retention of Penicillium spores was equivalent for mixed cellulose ester (MCE) filters with pore sizes of 1.2 um and 3 um. However, a 5 um pore size resulted in about a 20% reduction in the average retention for 3 um Penicillium spores. The average ratios of BA to AOC concentrations for P. chrysogenum spores were 2.0, 1.8, and 1.7 at airflow rates of 1 lpm, 2 lpm, and 3 lpm, respectively. The average ratio of BA to AOC concentrations for S. chartarum at the three airflow rates was 1.1. The edges of the BA sample trace were well defined and bounded, and the sample area did not vary between samples. The constant size of the BA sample trace allowed less than 100% of the sample to be analyzed without affecting the precision of the analysis.
Examining the impact of mindfulness and self-compassion on the relationship between mental health and resiliency

participants and procedure One questionnaire comprised four pre-developed questions, examining mental health (i.e., depression, anxiety and stress), resilience, mindfulness and self-compassion. Participants (N = 551) were recruited from the general public across the West and East Midlands of England. results The results showed that poor mental health was related negatively to resilience. Furthermore, the negative relationship of resiliency with mental health was mediated when controlling for mindfulness and self-compassion.
STUDY OF CONSUMER ACCEPTANCE ABOUT THE POTENTIAL INTRODUCTION IN 3 THE MARKET OF A CHEESE WITH BERRIES 4 5 Running Title : CONSUMER SURVEY ABOUT A NEW CHEESE PRODUCT 6 7

22 BACKGROUND: Nowadays, consumers are more concerned about the issues related to the 23 maintenance and promotion of health, trying to combine the pleasure in the consumption of certain 24 foods with health benefits. Therefore, there has been an increasing in the market of functional foods. 25 OBJECTIVE: The present study was carried out in order to explore the consumers’ acceptance 26 regarding the possibility of introducing in the market a new dairy product with functional properties, 27 namely a cheese with berries. 28 METHODS: A descriptive cross-sectional study was undertaken on a non-probabilistic sample of 29 335 adult participants. The questionnaires were applied online after informed consent only to adults 30 (aged 18 or over) and the data were collected from August 2016 to March 2017 among the 31 Portuguese population. 32 RESULTS: The results obtained showed that approximately 92% of the participants consumed 33 cheese of any type regularly and 50% consumed cheese two or three times per week. Most of the 34 participants (~62%) revealed that they did not consume any type of cheese with additional benefits. 35 CITATION: Ferrão AC, Guiné RPF, Correia PMR (2019) Study of Consumer Acceptance About the Possible Commercialization of a Cheese with Berries. Current Nutrition and Food Science, 15 (2), 185-195.
c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation

Rationale: NRF2, a redox sensitive transcription factor, is up-regulated in head and neck squamous cell carcinoma (HNSCC), however, the associated impact and regulatory mechanisms remain unclear. Methods: The protein expression of NRF2 in HNSCC specimens was examined by IHC. The regulatory effect of c-MYC on NRF2 was validated by ChIP-qPCR, RT-qPCR and western blot. The impacts of NRF2 on malignant progression of HNSCC were determined through genetic manipulation and pharmacological inhibition in vitro and in vivo. The gene-set enrichment analysis (GSEA) on expression data of cDNA microarray combined with ChIP-qPCR, RT-qPCR, western blot, transwell migration/ invasion, cell proliferation and soft agar colony formation assays were used to investigate the regulatory mechanisms of NRF2. Results: NRF2 expression is positively correlated with malignant features of HNSCC. In addition, carcinogens, such as nicotine and arecoline, trigger c-MYC-directed NRF2 activation in HNSCC cells. NRF2 reprograms a wide range of cancer metabolic pathways and the most notable is the pentose phosphate pathway (PPP). Furthermore, glucose-6-phosphate dehydrogenase (G6PD) and transketolase (TKT) are critical downstream effectors of NRF2 that drive malignant progression of HNSCC; the coherently expressed signature NRF2/G6PD/TKT gene set is a potential prognostic biomarker for prediction of patient overall survival. Notably, G6PD- and TKT-regulated nucleotide biosynthesis is more important than redox regulation in determining malignant progression of HNSCC. Conclusions: Carcinogens trigger c-MYC-directed NRF2 activation. Over-activation of NRF2 promotes malignant progression of HNSCC through reprogramming G6PD- and TKT-mediated nucleotide biosynthesis. Targeting NRF2-directed cellular metabolism is an effective strategy for development of novel treatments for head and neck cancer.
Missing Stratospheric Ozone Decrease at Southern Hemisphere Middle Latitudes after Mt. Pinatubo: A Dynamical Perspective

Although large total ozone decreases occurred in the Northern Hemisphere extratropics in the years after the volcanic eruption of Mt. Pinatubo that are generally attributed to the eruption, comparable decreases did not emerge in the Southern Hemisphere. To study this missing decrease, a multiple linear regression was applied to the Chemical and Dynamical Influences on Decadal Ozone Change (CANDIDOZ) Assimilated Three-Dimensional Ozone (CATO) dataset including the solar cycle, the quasi-biennial oscillation (QBO), the effect of volcanic eruptions, the lower stratospheric (LS) Eliassen–Palm (EP) flux to describe the Brewer– Dobson circulation, and stratospheric chlorine increase as explanatory variables. Volcanically induced chemical ozone depletion was overcompensated by the QBO and by a pronounced EP flux anomaly. Using NCEP–NCAR reanalysis data, it is found that the anomalous EP flux was caused by several significant stratospheric wave events (SWEs) from September–November 1991 through 1992 that, together with aerosol heating, led to a significantly enhanced Brewer–Dobson circulation and more ozone transport from the tropics to the extratropics. The onset of the volcanic ozone loss was shifted into 1992 and the strength of the signal was reduced.Most SWEs can be traced back to the troposphere and a significant fractionwas associated with atmospheric blocking patterns preceding the SWEs. In 1991/92, the southern annular mode was in a negative phase and El Niño–Southern Oscillation in a warm phase. It is suggested that this constellation favored a flow preconditioning toward quasi-stationary features including blocking, which was significantly enhanced in 1991/92. During June–August 1992, blocking occurred preferably over the southeastern Pacific, pointing to a major ENSO influence on LS wave activity.
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The aim of this study is to elucidate the association of focal adhesion kinase (FAK) in HGF-mediated cell proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1. The knowledge from this study may lead to alternative treatments for cholangiocarcinoma such as signaling inhibition. HuCCA-1 cells was found to express HGF and c-met whereas rhHGF was able to induce cell proliferation and invasion of HuCCA-1 cells. This indicated both paracrine and autocrine functions of HGF to regulate HuCCA-1 cell proliferation and invasion. FAK and Src were phosphorylated by HGF induction and the HGF-induced FAK and Src phosphorylations were time-dependent. The time point for maximal level of Src phosphorylation was earlier than FAK phosphorylation. Moreover, HGF could also induce FAK-Src interaction in time-dependent manner and the time point for FAK-Src interaction was well correlated with Src phosphorylation. These results suggested that Src may be an upstream molecule of FAK in HGF-induced signaling pathway. In addition, M555130, the inhibitor for Src kinase activity, was proved for its potential on FAK phosphorylation inhibition but not Src phosphorylation. The M555130 concentration that could inhibit HGF-induced FAK phosphorylation was lower than the non-induced one. This confirmed that Src was an upstream signaling molecule of FAK and Src had closely interaction to FAK in HGF-induced pathway. M555130 could also inhibit HGF-induced cell proliferation in HuCCA-1 cells and it was noted that the concentration which inhibit cell proliferation was positive correlated to that which inhibit FAK phosphorylation indicated that FAK plays important role in HGF-induced cell proliferation in HuCCA-1 cells. In contrast, cell invasion inhibition by M555130 was dependent on the inhibitor concentration indicated that, not only FAK but other downstream substrates for Src also play role in HGF-induced cell invasion in HuCCA-1 cells. FAK inhibition was also performed by FRNK transfection and the result showed equal level of FAK phosphorylation between FRNK transfected and nontransfected cells under HGF induction. This suggested that HGF-induced FAK phosphorylation and anchorage-dependent FAK phosphorylation were concomitantly but independently occurred in HuCCA-1 cells.
Parlez-vous Java? Bonjour La Monde != Hello World: Barriers to Programming Language Acquisition for Non-Native English Speakers

Learning computer programming could and should be made easier. It is widely accepted that learning to program is fraught with challenges and the literature is not short of work that supports this view. There are many studies related to programming difﬁculties, barriers, and misconceptions as well as topics such as what language is best for learning and what techniques for teaching programming are most effective. It is often overlooked that globally, the majority of programming students are non-native English speakers. In addition to the barriers faced by all programming students, these non-native English speakers face a substantial class of additional barriers. This is because English is often the language upon which programming languages and their documentation are based, as well as the language of instruction and other environmental conditions. There have been relatively few studies on the impact of human language on learning programming and the potential barriers this may cause. These barriers also span a wider range than may be obvious upon initial inspection. To complicate matters, natural language issues can add an additional layer of complexity to more universal barriers to learning. For instance it is well known that programming error messages present most novice programmers with difﬁculty. When these messages are in English as they most often are, any difﬁculties interpreting them and using them to produce error-free code are most likely compounded for non-native English speakers. Particularly in a time when broadening participation in computing is a primary objective, the community can no longer afford to overlook the unique barriers faced by non-native English speakers who want to learn to program. This paper discusses these barriers, presents some questions to guide future research, and outlines the author’s work-in-progress in the area.
REPRESENTATIONAL AUTOBIOGRAPHICAL NOSTALGIC MEMORIES: AN INTERGENERATIONAL COMPARATIVE STUDY INVOLVING NATIVE AND IMMIGRANT GREEKS

Nostalgia is defined as a reconstruction of important representational memories in the present. The present study aimed to investigate the process of objectification of nostalgic memories, and, also, the effects of gender, age/ generation, country of residence, and rate of occurrence of nostalgic memories. It draws on data from a sample of 226 female and male Greek natives and immigrants residing in Germany. The participants belonged to three different generations (young adults/children, adults/parents, elders/grandparents). They completed an open-ended questionnaire on nostalgic experiences, the associated reasons and elicited emotions. They also responded to the Southampton Nostalgia Scale measuring proneness to nostalgia. The results showed that nostalgic memories involved interactions with significant others, first-time experiences, places, periods of one’s life, and important events that contributed to the person’s identity formation (reasons). The elicited emotions were both positive and negative. Correspondence analysis showed that nostalgic memories were associated with participants’ immigration status (native/ immigrant) and generation. Immigrants and elderly participants were more sensitive to the nostalgic process. The implications of the study are discussed in terms of social representations of nostalgic memories and their interaction with identity dimensions.
IET Submission Template

In the past, the diffusion of electric vehicles (EVs) has been hindered by energy storage limits. In fact, these are the reason for the limited EV range and the consequent range anxiety of their drivers. Thanks to constant improvements in storage system technologies over the years, in terms of both energy and power density, lithium ion batteries (LiBs) now guarantee vehicle ranges higher than 150 km for small vehicles. Another important improvement has been achieved by the hybridization of LiBs with other storage technologies such as electric double layer capacitors or lithium ion capacitors. By adding an additional storage unit (ASU) to the EV battery system, the overall efficiency increases, with a consequent gain in the vehicle’s expected range. In a previous paper, an optimal sizing procedure was proposed, through which it is possible to calculate the optimal ASU mass that maximizes the EV range for a given vehicle, ambient conditions, and driving cycle, which was considered to be known a priori. In the present work, a real time implementation of the control strategy on which the optimal sizing procedure was based is proposed and analyzed using the results of simulation tests.
Kremer Active and Adaptive Learning from Biased Data with Applications in Astronomy

Astrophysics and cosmology are rich with data. The advent of wide-area digital cameras on large aperture telescopes has led to ever more ambitious surveys of the sky. The data volume of an entire survey from a decade ago can now be acquired in a single night and real-time analysis is often desired. Thus, modern astronomy requires big data know-how, in particular it demands highly efficient machine learning and image analysis algorithms. But scalability is not the only challenge: Astronomy applications touch several current machine learning research questions, such as learning from biased data and dealing with label and measurement noise. We argue that this makes astronomy a great domain for computer science research, as it pushes the boundaries of data analysis. We present this exciting application area for data scientists. The article focuses on exemplary results, discusses main challenges, and highlights some recent methodological advancements in machine learning and image analysis triggered by astronomical applications.
СROSS-BORDER APPROACH TO REGIONS’ SMART SPECIALIZATION: EXPERIENCE OF THE EU MEMBER STATES

In the recent decade, the EU Member States have been actively implementing the regional development policy based on innovative strategies of smart specialization. However, lately, European researchers have been paying increasing attention to the issues of regions’ capacity to overcome the boundaries of administrative units inside the country and abroad and to the need to consider regions in the context of their functioning among others, especially from the viewpoint of the growing role of their innovative networks in global value chains. That is why currently the EU is addressing the development of cross-border smart specialization strategies. The paper aims to study the European experience on the functioning of cross-border innovation systems and joint strategic planning of cross-border regions’ development based on smart specialization and to outline the opportunities to implement the EU experience of cross-border approach to smart specialization in cross-border regions of Ukraine with EU Member States. The paper analyzes the views of foreign researchers on the links between innovation systems in cross-border space that constitute the theoretical basis of the study of cross-border smart specialization strategies, namely regarding the dimensions and level of their development. The research of European scientists on cross-border innovation systems in specific cross-border regions is examined, in particular on Spanish-French and German-French borders. Directions of implementation of smart specialization projects in cross-border context under the EU programs and other EU instruments that support regions in cooperation for the elaboration of joint view of development with neighbouring economically, socially, culturally, and historically close regions are outlined. The experience and methodology of the first cross-border smart specialization strategy for Spanish and Portuguese regions are studied in detail. The opportunities to use the EU experience by several Western Ukrainian regions based on the joint smart specialization priorities with the neighboring EU states are outlined. For this purpose, 1) the RIS3 strategies of the regions of Poland and Romania adjoining Ukraine and Regional Development Strategies of respective Ukrainian regions were analyzed to detect similar smart specialization priorities; 2) the clusters in the mentioned regions were analyzed as main drivers of achievement of smart specialization goals to detect similar or complementary functioning areas.
Prolonged positive modulation of AMPA receptors induces calpain-mediated PDZ protein degradation and AMPA receptor down-regulation in cultured hippocampal slices.

Prolonged exposure of cultured hippocampal slices to CX614, a positive AMPA receptor (AMPAr) modulator, decreases receptor response to synaptic stimulation, an effect that could reflect reduced receptor expression. The present study investigates this down-regulation and its underlying mechanisms using cultured rat hippocampal slices. Chronic treatment with CX614 gradually reduced levels of GluR1 and GluR2/3 AMPAr subunits and of their anchoring proteins, SAP97 and GRIP1 through 48 h. Decline in SAP97 and GRIP1 levels was associated with increased abundance of lower molecular weight bands, suggesting degradation of these proteins. CX614 effects were partially reversible following drug removal. GluR1 and GluR2/3 down-regulation and their slow recovery were associated with similar changes in SAP97 and GRIP1 levels. Treatment with CX614 for 48 h significantly reduced AMPAr mRNA levels in hippocampus whereas 8 h exposure did not. Blockade of ionotropic glutamate receptors prevented CX614-induced decrease in AMPAr subunits and mRNA, with regional selectivity, although an AMPAr blocker was more efficacious than an NMDAr blocker. Blockade of calpain activity reduced CX614-induced degradation of SAP97 and GRIP1 and prevented decreases in AMPAr subunit but not mRNA levels. Treatment with CX614 alone or in combination with glutamate receptor blockers or calpain inhibitor III did not modify lactate dehydrogenase release into culture medium, implying the absence of cell toxicity. We conclude that CX614-induced AMPAr protein loss is primarily mediated by AMPAr activation, and involves calpain-dependent proteolysis of SAP97 and GRIP1. CX614-induced suppression of AMPAr gene expression is, however, calpain-independent and all these effects are not associated with cell damage.
Study of the thermal conductivity of PbS , CuFeS 2 , ZnS © 2020

It is necessary to know the values of the thermal conductivity coeffi cient of a semiconductor material to assess the possibility of its application as a thermoelectric. The thermal conductivity of natural minerals of galena (PbS), chalcopyrite (CuFeS2), and ZnS ceramics was studied using the absolute stationary method of longitudinal heat fl ux in the range of 50–300 K. The samples were homogeneous, had low impurity content (the chemical composition of the samples was controlled by the X-ray fl uorescence method) and were characterized by high electrical resistivity (r > 9·10–2 Ohm·m at room temperature). It corresponds to the electronic component of the thermal conductivity ke < 1·10 –4 W/(m·K). The results of the thermal conductivity measurements are presented graphically and in tabular form. All the dependences are shown to be decreasing. The thermal conductivity values (W/(m·K)) at 50 K amount to 10.9 for PbS, 62 for CuFeS2, and 73-98 for ZnS. At 300 K the values are 2.48, 10.5 and 18.6 – 18.8 W/(m·K), respectively. All the studied materials have much worse thermal conductivity than pyrite (FeS2). The obtained data was compared to the data available in literary sources. The temperature dependence of the thermal conductivity of galena is low, its low thermal conductivity is favourable for thermoelectric applications. The thermal conductivity of chalcopyrite, which was detected in this study, appeared to be the highest among the corresponding literature data. The high thermal conductivity of zinc sulphide correlates to its wide variability depending on the structural features of the material. The temperature dependences of the mean free path of phonons were calculated. The values of this characteristic, estimated for the melting temperature, for PbS and for ZnS, in particular, signifi cantly exceed the size of an elementary crystal cell, which is unusual.