Miracle-dz/UniFAR-FTUs huggingface dataset:
The niche variation hypothesis and the evolution of colour polymorphism in birds: a comparative study of owls, nightjars and raptors

We studied the evolution of colour polymorphism in diurnal raptors, owls and nightjars, the avian taxa in which this trait is most widespread, in relation to species ecological niche width and diet. Two main mechanisms have been put forward to explain the maintenance of polymorphism, namely apostatic selection and disruptive selection. The niche variation hypothesis states that species with broader ecological niches should be more variable compared with those with narrow niches because of the action of disruptive selection; the apostatic selection hypothesis conversely suggests that intraspecific colour variation should be promoted in predators by prey forming an avoidance image for the more common colour morph. Our aim was to determine if colour polymorphism occurrence was associated with broad ecological niches as predicted by the niche variation hypothesis, or with predation on intelligent and sharp-sighted prey as predicted by the avoidance image hypothesis. Pairwise comparisons were made between pairs of closely related species differing in variables expected to influence the occurrence of polymorphism. We found that polymorphic species of all three groups showed wider and more continuous distribution ranges, frequented many different habitats, both open and closed, and lived in seasonally alternating dry/wet climates. Polymorphic species were more migratory compared with monomorphic ones, and they showed an activity pattern covering both day and night. Conversely, colour polymorphism was not higher in species preying on birds and mammals. All these findings support the hypothesis that colour polymorphism evolved in bird species with wider niche breadth and not in species preying on intelligent prey. Therefore, we propose that disruptive selection may be the main mechanism maintaining colour polymorphism in these bird groups by favouring different morphs in different environmental conditions.
JMJD5 couples with CDK9 to release the paused RNA polymerase II

Significance RNA polymerase II (Pol II) is stalled at the transcription starting site for a large number of genes in higher eukaryotes. We previously found that JMJD5/7 proteins act as both endopeptidases and exopeptidases to cleave arginine methylated histone tails including those of H2A, H3, and H4, thus generating relatively “tailless nucleosomes”, which can be overcome by Pol II. This report shows that knockout of JMJD5 in mice leads to accumulation of nucleosomes at +1 and loss of expression of a large number of genes. We find that the N-terminal domain of JMJD5 binds to CTD of Pol II with a unique combination of phosphorylation generated by CDK9. We propose that JMJD5 couples with CDK9 to release the paused Pol II. More than 30% of genes in higher eukaryotes are regulated by RNA polymerase II (Pol II) promoter proximal pausing. Pausing is released by the positive transcription elongation factor complex (P-TEFb). However, the exact mechanism by which this occurs and whether phosphorylation of the carboxyl-terminal domain of Pol II is involved in the process remains unknown. We previously reported that JMJD5 could generate tailless nucleosomes at position +1 from transcription start sites (TSS), thus perhaps enable progression of Pol II. Here we find that knockout of JMJD5 leads to accumulation of nucleosomes at position +1. Absence of JMJD5 also results in loss of or lowered transcription of a large number of genes. Interestingly, we found that phosphorylation, by CDK9, of Ser2 within two neighboring heptad repeats in the carboxyl-terminal domain of Pol II, together with phosphorylation of Ser5 within the second repeat, HR-Ser2p (1, 2)-Ser5p (2) for short, allows Pol II to bind JMJD5 via engagement of the N-terminal domain of JMJD5. We suggest that these events bring JMJD5 near the nucleosome at position +1, thus allowing JMJD5 to clip histones on this nucleosome, a phenomenon that may contribute to release of Pol II pausing.
Renin-Angiotensin System Blockade and Mortality in Patients With Hypertension and COVID-19 Infection

To determine the effect renin-angiotensin system blockers on the outcome in patients with hypertension and concurrent COVID-19 infection, we searched PubMed, the Cochrane Library, and Google Scholar for relevant articles. Twelve studies with a total of 16,101 patients met the inclusion criteria. The mortality rate among the users of angiotensin converting enzyme inhibitors or angiotensin receptor blockers was 12.15% and in non-users it was 14.56% (risk ratio 0.70, 95% CI [0.53-0.91], P < 0.007). There was no difference in the risk of death between the use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers (risk ratio 1.09, 95% CI [0.90 -1.32]). We conclude that the use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers improves mortality in patients with hypertension and concurrent COVID-19 infection, without a significant difference between ACEIs and ARBs in this population.
Dispersing Content Over Networks in Information-Centric Networking

Information-centric networking (ICN), a new network architecture for efficiently delivering content, has been widely investigated recently. In ICN, cache memory is implemented at each router, and content items are routed in the network by using content name as the locator determining the destination. The caching strategy that determines the content to be cached at each router strongly affects the cache hit ratio and flow hop length, and it is important to efficiently utilize limited cache resources by avoiding duplicated caching of the same content among routers located closely. In this paper, we propose a spatially dispersed caching (SDC), which is a caching strategy dispersing content by assigning a binary ID to each router and limiting the cache targets at each router to content with names whose hash value coincides with the router ID. Through computer simulations using backbone networks of actual ISPs in the United States, we show that the SDC improves the cache hit ratio by about 30%–170% compared with the case when caching content at all routers on the default path, and the SDC reduces the average hop length at cache hit by about 50%–90% compared with the existing caching strategies. Moreover, we show that the SDC improves the sustainable ratio of content acquisition in large-scale failures of routers by about 25%–200% compared with the existing caching strategies.
The Mineral Nutrition of Higher Plants

Broadly, the approach which researchers have adopted in this review has been to ask the following questions about mineral nutrients: What properties make them essential. How are they obtained. How effectively are they used. We shall not be considering two most important, but frequently reviewed, aspects of the subject, namely biological fixation of N/sub 2/ and its assimilation and mechanisms of membrane transport.
The possible role of environmental calcum levels during the evolution of phenotypic diversity in Outer Hebridean populations of the Three-spined stickleback, Gasterosteus aculeatus

Rarely Gasterosteus aculeatus populations occur where many individuals have lost their protective dorsal spines, ventral spines, pelvic girdle and lateral bony plates. Reduction in predation pressure is currently viewed as the causative factor. On the lsle of North Uist (Outer Hebrides) 10 spine-deficient G. aculeatus populations, sympatric with various fish and bird predators are described. All of the spine-deficient morph sticklebacks are found in acidic oligotrophic peat moorland lakes and pools where Ca2+ is ≤ 2.5 mg/1. It is proposed that calcium deficiency may have been an important selective agency in the evolution of skeletal reduction in these unusual populations.
RAPD variation within and among populations of globe artichoke cultivar 'Spinoso sardo'.

Globe artichoke is a vegetable native to the Mediterranean basin. Its commercial production is mainly based on perennial cultivation of vegetatively propagated clones, which are highly heterozygous and segregate widely when progeny-tested. The aim of this study was to measure genetic variation using random amplified polymorphic DNA (RAPD) in five populations of ‘Spinoso sardo’, the most widely grown and economically important cultivar in Sardinia (Italy). Analysis of molecular variance (amova) gave highly significant differences between populations (28.1% of the total genetic diversity); substantial within-population variation was detected (71.8% of total genetic diversity). The RAPD results show the need to apply clonal selection to narrow the broad genetic variability within the cultivar and to address important questions on the most suitable strategies for germplasm preservation.
Big Data Analysis of Sports and Physical Activities among Korean Adolescents

The Korean government (Ministry of Culture, Sports and Tourism, Ministry of Health and Welfare, and Ministry of Education) has framed policies and conducted many projects to encourage adolescents to be more physically active. Despite these efforts, the participation rate of physical activity in Korean adolescents keeps decreasing. Thus, the purpose of this study was to analyze the perception of sports and physical activity in Korean adolescents through big data analysis of the last 10 years and to provide research data and statistical direction with regard to sports and physical activity participation in Korean adolescents. For data collection, data from 1 January 2010 to 31 December 2019 were collected from Naver (NAVER Corp., Seongnam, Korea), Daum (Kakao Corp., Jeju, Korea), and Google (Alphabet Inc., Mountain View, CA, USA), which are the most widely used search engines in Korea, using TEXTOM 4.0 (The Imc Inc., Daegu, Korea), a big data collection and analysis solution. Keywords such as “adolescent + sports + physical activity” were used. TEXTOM 4.0 can generate various collection lists at once using keywords. Collected data were processed through text mining (frequency analysis, term frequency–inverse document frequency analysis) and social network analysis (SNA) (degree centrality, convergence of iterated correlations analysis) by using TEXTOM 4.0 and UCINET 6 social network analysis software (Analytic Technologies Corp., Lexington, KY, USA). A total of 9278 big data (10.36 MB) were analyzed. Frequency analysis of the top 50 terms through text mining showed exercise (872), mind (851), health (824), program (782), and burden (744) in a descending order. Term frequency–inverse document frequency analysis revealed exercise (2108.070), health (1961.843), program (1928.765), mind (1861.837), and burden (1722.687) in a descending order. SNA showed that the terms with the greatest degree of centrality were exercise (0.02857), program (0.02406), mind (0.02079), health (0.02062), and activity (0.01872) in a descending order. Convergence of the iterated correlations analysis indicated five clusters: exercise and health, child to adult, sociocultural development, therapy, and program. However, female gender, sports for all, stress, and wholesome did not have a high enough correlation to form one cluster. Thus, this study provides basic data and statistical direction to increase the rate of physical activity participation in Korean adolescents by drawing significant implications based on terms and clusters through bid data analysis.
The stress response and the plasma disappearance of corticosteroid and glucose in a marine teleost, the sea raven

The objective of the study was to examine the physiological response to stress in a marine species with a sluggish life-style. The sea raven (Hemitripterus americanus), a marine benthic predator, did not produce elevated catecholamine levels when handled for blood removal, which facilitated repeated blood sampling from the same fish without cannulation. However, this species did release catecholamines in response to an acute stress (1 min of air exposure followed by 1 min of chasing), suggesting a high threshold (degree of external stimulation) for catecholamine release in this species. Plasma cortisol concentration increased significantly only after 1 h and remained elevated 4 h post-stress, showing a delayed response compared with salmonids. Plasma glucose concentration increased significantly at 0.5 h post-stress and remained elevated even at 24 h, while lactate levels dropped between 4 and 24 h post-stress. The delayed cortisol increase may not be due to altered plasma clearance, as no change in the p.
Advances in the Neurocognition of Music and Language

Neurocomparative music and language research has seen major advances over the past two decades. The goal of this Special Issue “Advances in the Neurocognition of Music and Language” was to showcase the multiple neural analogies between musical and linguistic information processing, their entwined organization in human perception and cognition and to infer the applicability of the combined knowledge in pedagogy and therapy. Here, we summarize the main insights provided by the contributions and integrate them into current frameworks of rhythm processing, neuronal entrainment, predictive coding and cognitive control.
The ameliorative effect of curcumin on cryptorchid and non-cryptorchid testes in induced unilateral cryptorchidism in albino rat: histological evaluation.

BACKGROUND Cryptorchidism, one or both hidden testes, is the most common abnormality of male sexual development. Subfertility or infertility is associated with both unilateral and bilateral cryptorchidism. In this study, we investigate the possible ameliorative effect of curcumin (Cur) on the induced-unilateral cryptorchidism testicular injury in both cryptorchid (Cryp) and non-cryptorchid (non-Cryp) scrotal testes through histological, immunohistochemical and morphometrics. MATERIALS AND METHODS 40 adult male albino rats were divided into: control group, Cur control, Cryp group, and Cryp+Cur group. The rat model was surgically established by fixing the left testis in the abdomen. The treated groups were subjected to surgically induced-unilateral cryptorchidism on the left side then were given Cur (80 mg/kg) orally, for 20 days. Histological analysis using hematoxylin & eosin and periodic acid Schiff's reaction was applied. Immunohistochemistry was performed for proliferating cell nuclear antigen (PCNA); to estimate the proliferation in the germinal epithelium, and vimentin; to evaluate Sertoli cells. The results were confirmed by statistical evaluation of the spermatogenic epithelium height, the seminiferous tubules diameter, the basement membrane thickness, the number of PCNA immunostained cells and the area % of vimentin immunostaining. RESULTS distorted seminefrous tubules, substantial degeneration of the germinal epithelium, thickening of the basement memebrane with a significant decrease in PCNA and vimentin immunostaining were observed in Cryp group; mainly in the cryptorchid testis. These structural changes were significantly reversed in Crypt+Cur group. CONCLUSIONS Curcumin proved to be an important and effective medical line for protecting against the unfavorable sequels of cryptorchidism in a rat model.
Deep Representation-Based Domain Adaptation for Nonstationary EEG Classification

In the context of motor imagery, electroencephalography (EEG) data vary from subject to subject such that the performance of a classifier trained on data of multiple subjects from a specific domain typically degrades when applied to a different subject. While collecting enough samples from each subject would address this issue, it is often too time-consuming and impractical. To tackle this problem, we propose a novel end-to-end deep domain adaptation method to improve the classification performance on a single subject (target domain) by taking the useful information from multiple subjects (source domain) into consideration. Especially, the proposed method jointly optimizes three modules, including a feature extractor, a classifier, and a domain discriminator. The feature extractor learns the discriminative latent features by mapping the raw EEG signals into a deep representation space. A center loss is further employed to constrain an invariant feature space and reduce the intrasubject nonstationarity. Furthermore, the domain discriminator matches the feature distribution shift between source and target domains by an adversarial learning strategy. Finally, based on the consistent deep features from both domains, the classifier is able to leverage the information from the source domain and accurately predict the label in the target domain at the test time. To evaluate our method, we have conducted extensive experiments on two real public EEG data sets, data set IIa, and data set IIb of brain–computer interface (BCI) Competition IV. The experimental results validate the efficacy of our method. Therefore, our method is promising to reduce the calibration time for the use of BCI and promote the development of BCI.
Increased lipopolysaccharide‐induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE2 production and increased heat loss

The mechanisms involved in hypothermia and fever during systemic inflammation (SI) remain largely unknown. Our data support the contention that brain‐mediated mechanisms are different in hypertension during SI. Considering that, clinically, it is not easy to assess all mechanisms involved in cardiovascular and thermoregulatory control during SI, the present study sheds light on these integrated mechanisms that may be triggered simultaneously in septic hypertensive patients. The result obtained demonstrate that, in lipopolysaccharide‐induced SI, an increased hypothermia is observed in neurogenic hypertension, which is caused by reduced hypothalamic prostaglandin E2 production and increased heat loss in conscious rats. Therefore, the results of the present study provide useful insight for clinical trials evaluating the thermoregulatory outcomes of septic patients with hypertension.
Lung macrophages are involved in lung injury secondary to repetitive diving

This study aimed to establish an animal model of decompression-induced lung injury (DILI) secondary to repetitive diving in mice and explore the role of macrophages in DILI and the protective effects of high-concentration hydrogen (HCH) on DILI. Mice were divided into three groups: control group, DILI group, and HCH group. Mice were exposed to hyperbaric air at 600 kPa for 60 min once daily for consecutive 3 d and then experienced decompression. In HCH group, mice were administered with HCH (66.7% hydrogen and 33.3% oxygen) for 60 min after each hyperbaric exposure. Pulmonary function tests were done 6 h after decompression; the blood was harvested for cell counting; the lung tissues were harvested for the detection of inflammatory cytokines, hematoxylin and eosin (HE) staining, and immunohistochemistry; western blotting and polymerase chain reaction (PCR) were done for the detection of markers for M1 and M2 macrophages. Our results showed that bubbles formed after decompression and repeated hyperbaric exposures significantly reduced the total lung volume and functional residual volume. Moreover, repetitive diving dramatically increased proinflammatory factors and increased the markers of both M1 and M2 macrophages. HCH inhalation improved lung function to a certain extent, and significantly reduced the pro-inflammatory factors. These effects were related to the reduction of M1 macrophages as well as the increase in M2 macrophages. This study indicates that repetitive diving damages lung function and activates lung macrophages, resulting in lung inflammation. HCH inhalation after each diving may be a promising strategy for the prevention of DILI.
Tolerance to Sodium Monofluoroacetate in Dasyurids from Western Australia

The tolerances to sodium fluoroacetate (1080) were estimated for Dasyurus geoffroii (LD*50, ca. 7.5 mg 1080 kg-1), D. hallucatus (ca. 7.5 mg kg-1), Antechinus flavipes (ca. 11.0 mg kg-1) and Phascogale calura (ca. 17.5 mg kg-1) from Western Australia and comparisons were made with D. viverrinus (ca. 1.5 mg kg-1) and A. flavipes (ca. 3.5 mg kg-1) from south-eastern Australia. The species from Western Australia have had evolutionary exposure to naturally occurring fluoroacetate and were more tolerant to the toxin than dasyurids from south-eastern Australia, Presumably, they have acquired this tolerance through feeding on prey which had fed on plants containing fluoroacetate.
Cognitive-Affective Inconsistency and Ambivalence: Impact on the Overall Attitude–Behavior Relationship

This research explored whether overall attitude is a stronger predictor of behavior when underlying cognitive-affective inconsistency or ambivalence is low versus high. Across three prospective studies in different behaviors and populations (Study 1: eating a low-fat diet, N = 136 adults, eating five fruit and vegetables per day, N = 135 adults; Study 2: smoking initiation, N = 4,933 adolescents; and Study 3: physical activity, N = 909 adults) we tested cognitive-affective inconsistency and ambivalence individually and simultaneously as moderators of the overall attitude–behavior relationship. Across studies, more similar effects were observed for inconsistency compared with ambivalence (in both individual and simultaneous analyses). Meta-analysis across studies supported this conclusion with both cognitive-affective inconsistency and ambivalence being significant moderators when considered on their own, but only inconsistency being significant when tested simultaneously. The reported studies highlight the importance of cognitive-affective inconsistency as a determinant of the strength of overall attitude.