Miracle-dz/UniFAR-FTUs huggingface dataset:
Closing the accessibility gap to mental health treatment with a conversational AI-enabled self-referral tool

Accessing mental health care can be challenging, and minority groups often face additional barriers. This study investigates whether digital tools can enhance equality of access to mental health treatment. We evaluated a novel AI-enabled self-referral tool (a chatbot) designed to make entry to mental health treatment more accessible in a real-world setting. In a multi-site observational study, data were collected from 129,400 patients who referred to 28 separate NHS Talking Therapies services across England. Our results indicate that the tool led to a 15% increase in total referrals, which was significantly larger than the 6% baseline increase observed in matched services using traditional self-referral methods during the same time period. Importantly, the tool was particularly effective for minority groups, which included non-binary (235% increase), bisexual (30% increase), and ethnic minority individuals (31% increase). This paints a promising picture for the use of AI chatbots in mental healthcare and suggests they may be especially beneficial for demographic groups that experience barriers to accessing treatment in the traditional care systems. To better understand the reasons for this disproportional benefit for minority groups, we used thematic analysis and Natural Language Processing (NLP) models to evaluate qualitative feedback from 42,332 individuals who referred through the AI-enabled tool. We found that the tool's human-free nature and its ability to improve the perceived need for treatment were the main drivers for improved diversity. These findings suggest that AI-enabled chatbots have the potential to increase accessibility to mental health services for all, and to alleviate barriers faced by disadvantaged populations. The results have important implications for healthcare policy, clinical practice, and technology development.
Socioeconomic Inequality in Hearing Impairment Among Working-Age Australians: Evidence From a Cross-Sectional and Longitudinal Analyses

Objectives: The objective of this study was to analyze the spatial and temporal association between socioeconomic gradient in hearing impairment among working-age Australians. Design: We modeled the cross-sectional and longitudinal associations between individual- and area-level socioeconomic status (SES) and hearing impairment among working-age Australians using longitudinal data from the Household, Income and Labour Dynamics in Australia (HILDA) Survey for 10,719 working-age adults aged between 15 and 64 years surveyed between 2008 and 2018. Associations between self-reported hearing impairment and education, income, employment status, and area-level SES were estimated using a multivariate logistic regression model and Cox proportional hazards regression, controlling for age, sex, and a range of other sociodemographic factors. Results: Among 10,719 participants, the prevalence of hearing impairment was higher among individuals with lower income, occupational status and socioeconomic disadvantage. The odds ratio (OR) of those with the lowest income quintile versus highest income quintile (OR = 2.10, 95% confidence interval [CI] = 1.40 to 3.14); for blue-collar occupation versus white-collar (OR = 1.92, 95% CI = 1.39 to 2.66) and most disadvantaged area quintile versus most advantaged area quintile (OR = 1.76, 95% CI = 1.10 to 2.83) were associated with higher odds of prevalence of hearing impairment. For the 10,046 participants without hearing loss at baseline, income quintile 1 versus quintile 5 (hazard ratio [HR] = 1.44, 95% CI = 1.33 to 1.56), ≤ year 11 versus ≥ bachelor’s degree (HR = 2.15, 95% CI = 1.98-2.34) blue-collar occupation versus white collar (HR = 1.15, 95% CI = 1.07 to 1.25) and most disadvantaged area quintile versus most advantaged quintile (HR = 1.49, 95% CI = 1.37 to 1.63) was positively associated with incident hearing impairment. Conclusions: Lower individual-level and area-level SES was associated with an increased risk of prevalence and incidence of hearing impairment among working-age Australians. These findings are particularly concerning since working-age Australians are mostly not eligible for socially subsidized hearing-related health care in Australia. This lack of access to affordable hearing services could exacerbate the negative consequences of hearing impairment and increase social inequality.
Ultra-high-definition (22 MHz) ultrasound of the ulnar nerve: additional value and normative data

We studied 30 healthy volunteers (60 arms), categorized into three age groups with equal numbers to verify if a 22 MHz compared with a 15 MHz ultrasound transducer has additional value for studying the intraneural architecture of the ulnar nerve throughout its course. At six sites, there were no differences in cross-sectional area measurements between the two transducers. With both, the cross-sectional area was significantly larger at the medial epicondyle compared with the other sites and smaller at the mid-forearm and Guyon’s canal compared with the mid-upper arm. With higher age the cross-sectional area significantly increased. Significantly more fascicles were visible distal to the medial epicondyle compared with more proximal sites, as well as in men compared with women. Finally, higher body weight was related to a significantly smaller number of fascicles being seen. A 22 MHz transducer depicts more details of the intraneural architecture than a 15 MHz transducer. Our data can be used as normative data or reference values in analysing ulnar nerve pathology. Level of evidence: II
Affective arousal temporally precedes dissociation in patients with borderline personality disorder: A preliminary experience sampling study.

OBJECTIVE Affective dysregulation is a core feature of borderline personality disorder (BPD), and some patients report dissociative symptoms. The present study investigated temporal dynamic relations between affective states and current experiences of depersonalization and derealization in daily life to test key theoretical premises of trauma models of dissociation. METHOD Patients with BPD (n = 42) or depressive disorders (n = 40), and nonclinical controls (n = 39) were assessed every 15 min for 13 hr within a single day using smartphone-based diaries. RESULTS As expected, dynamic structural equation modeling results show the highest levels of average daily affective arousal, negative affective valence, and dissociation in the BPD group. As hypothesized, arousal and subsequent dissociation were significantly linked only in the BPD group, implying that momentary arousal above a person's daily average is followed by higher dissociation in the next measurement (∼15 min later). In addition, some patients with BPD reported less negative affective valence following dissociation. CONCLUSIONS Our findings suggest that changes in affective states play an important role at the onset of dissociation in patients with BPD. Subsequent relief from distress may explain maintenance. We recommend that clinicians provide means to regulate affect when dealing with dissociation. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Physical Activity and Nonalcoholic Fatty Liver Disease: A Roundtable Statement from the American College of Sports Medicine.

ABSTRACT Although physical activity (PA) is crucial in the prevention and clinical management of nonalcoholic fatty liver disease (NAFLD), most individuals with this chronic disease are inactive and do not achieve recommended amounts of PA. There is a robust and consistent body of evidence highlighting the benefit of participating in regular PA, including a reduction in liver fat and improvement in body composition, cardiorespiratory fitness, vascular biology and health-related quality of life. Importantly, the benefits of regular PA can be seen without clinically significant weight loss. At least 150 minutes of moderate or 75 minutes of vigorous intensity PA are recommended weekly for all patients with NAFLD, including those with compensated cirrhosis. If a formal exercise training program is prescribed, aerobic exercise with the addition of resistance training is preferred. In this roundtable document, the benefits of PA are discussed, along with recommendations for 1) PA assessment and screening; 2) how best to advise, counsel and prescribe regular PA and 3) when to refer to an exercise specialist.
Prevalence of Dental Anomalies in Various Categories of Malocclusion among Orthodontic Patients in the Kosovo Region: A Retrospective Study

Abstract Objectives The objective of this retrospective research was to investigate the prevalence and the association between dental anomalies and malocclusion in a subset of Kosovo's population. Materials and Methods This retrospective descriptive study was conducted by recruiting 557 patients; 215 (38.6%) were males and 342 (61.4%) were females. The age range was from 7 to 44 years. The exclusion criteria were employed for the sample size, and 307 of 864 patients were excluded from the study. Malocclusion groups were divided through Angle's classification, and dental anomalies were defined according to the literature. Pretreatment panoramic radiographs, medical and dental history, study casts, and photographs were included to categorize malocclusion and identify dental anomalies (i.e., hypodontia, ectopic eruption, impaction, and diastema). The data were analyzed with IBM SPSS software version 16.0. The chi-squared test was utilized to calculate the frequency and percentages of malocclusion and dental anomalies. A p -value of 0.05 was considered statistically significant. Results Five hundred and fifty-seven patient records from 2015 to 2020 were included. An increased prevalence of ectopic eruption (24.8%) was found in this study, whereas the least common was hypodontia (7.0%). The most common malocclusion was class I (46.9%). Vertical plane malocclusion demonstrated that 31.4% had a deep bite and 9.5% had an open bite. Most dental anomalies were significantly associated with class I malocclusion and least associated with class III malocclusion. Transverse malocclusion exhibited that 14% had anterior crossbite and 10.8% had posterior crossbite. Posterior crossbite was significantly less in the class III malocclusion group ( p = 0.019). Conclusion The prevalence of the selected dental anomalies was overall high in our study; 557 of 864 patients faced dental anomalies. An association was seen between malocclusion and dental anomalies in the Kosovan population, especially with class I malocclusion. Deep bite was prominent in the vertical plane malocclusion, whereas anterior crossbite was the most common finding in the transverse plane. Anterior crowding was prevalent in the maxilla and posterior crowding in the mandible.
Probabilistic Prediction of Oceanographic Velocities with Multivariate Gaussian Natural Gradient Boosting

Abstract Many single-output regression problems require estimates of uncertainty along with the point predictions. For this purpose, there exists a class of regression algorithms that predict a conditional distribution rather than a point estimate. The off-the-shelf options are much more limited, however, when the prediction output is multivariate and a joint measure of uncertainty is required. In this paper, we predict a distribution around a multivariate random vector of dimension P, such that the joint uncertainty would quantify the probability of any vector in P-dimensional space. This is more expressive than providing separate uncertainties in each dimension. To enable joint probabilistic regression, we propose a natural gradient boosting approach based on nonparametrically modeling the conditional parameters of the multivariate predictive distribution, where we focus on the multivariate Gaussian distribution. Our method is robust, can be easily trained without extensive tuning, and performs competitively in comparison to existing approaches. The motivating application of our methodology is to predict two-dimensional oceanographic currents measured by freely floating Global Drifter Program drifters using remotely sensed data. We also demonstrate the method’s performance on simulated data. We find this method excels when strong correlation between output dimensions is present. As part of this work, we have added the model to the open source package at github.com/stanfordmlgroup/ngboost.
Associations between Social Support Dimensions and Resilience Factors and Pathways of Influence in Depression and Anxiety Rates in Young Adults

Abstract Emerging adulthood is an important developmental period, associated to mental health risk. Resilience research points to both social and personal protective factors against development of psychopathology, but there is paucity with their comprehensive study in young adults. This study provides and initial integrative approach to model multiple dimensions of perceived social support (i.e., from family, friends, significant others) and personal factor of trait resilience (i.e., coping and persistence during stress, tolerance to negative affect, positive appraisals, trust) and their hypothesized contributions to reducing depression and anxiety rates. The study was conducted with a sample of 500 Spanish emerging adults (18 to 29 years old). Regression analyses and multiple mediation models were performed to test our hypotheses. Results showed that social support from family was the dimension with the highest strength relating individual differences in resilience. Furthermore, analyses supported a differential mediating role of specific resilience factors (coping and persistence during stress, tolerance to negative affect, positive appraisals, trust) in partially accounting for the association between higher social support from family and lower depression and anxiety levels in young adults. These results may inform new programs of mental health during emerging adulthood via the promotion of different sources of social support and their related resilience pathways contributing to low emotional symptomatology at this stage of development.
Heavy Rainfall: Contrasting Two Concurrent Great Plains Thunderstorms

Abstract Measurement and forecasting of heavy rainfall requires interpretation of the small differences in the storm environment that distinguish a major flood-producing rainfall event from a relatively harmless storm system. This case study will examine some of the small differences in the storm environment that lead to a heavy rainfall event. On 8 July 1994 two storm systems developed in close proximity to each other in central Oklahoma. One of the storms developed into a squall line and produced low storm total precipitation accumulations. The other was a slow-moving multicellular storm that produced storm total precipitation of more than 130 mm and small stream flooding. The storms exhibited contrasting measurement errors in the operational WSR-88D rainfall products, with underestimation for the heavy rain event and overestimation for the squall line. The interactions of synoptic, mesoscale, and storm-scale processes for the 8 July storms are examined through analyses of WSR- 88D reflectivity and Dopp.
Abacavir causes leukocyte/platelet crosstalk by activating neutrophil P2X7 receptors thus releasing soluble lectin‐like oxidized low‐density lipoprotein receptor‐1

Abacavir, an antiretroviral drug used in HIV therapy associated with myocardial infarction, promotes thrombosis through P2X7 receptors. The role of platelets as pro‐thrombotic cells is acknowledged whereas that of neutrophils—due to their secretory capacity—is gaining recognition. This study analyses the role of neutrophils—specifically the secretome of abacavir‐treated neutrophils (SNABC)—in platelet activation that precedes thrombosis.
IT Professionals' Turnaway Intention and the Role of Technostress

The supply of global information technology (IT) workers does not meet the demand of the industry. Therefore, researchers try to distill ways to increase and retain the IT talent pipeline. Ensuring that IT professionals remain in their IT careers is an essential element of such research. The influence of technostress on job turnover is evident. Yet, we know little about the impact of technostress on career turnaway and its interaction effects on the antecedents of turnaway intention. While job turnover may negatively impact a specific organization, career turnaway has negative implications for the industry. Losing IT professionals from the field means that additional efforts toward motivating, recruiting, educating, and preparing replacement talent are needed. By examining the dynamics of technostress on IT professionals' career turnaway intention (N=512), we reveal two critical findings. First, technostress reduces the IT professional's commitment to their IT career and increases exhaustion from their IT career experience. Second, technostress moderates IT professionals' commitment to their profession and career turnaway intentions. To remedy these concerns, we provide managerial advice and provide suggestions for future research.
Receptor-like cytoplasmic kinases belonging to different subfamilies mediate immune responses downstream of the Cf-4 resistance protein in Nicotiana benthamiana

Cell-surface receptors, which are either receptor-like proteins (RLPs) or receptor-like kinases (RLKs), form the first layer of the plant innate immune system. The LRR-RLKs SUPPRESSOR OF BIR1-1 (SOBIR1) and BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) are the common regulatory co-receptors of LRR-RLPs. The tomato LRR-RLP Cf-4, which specifically detects the apoplastic effector Avr4 that is secreted by the pathogenic intercellular fungus Cladosporium fulvum, requires SOBIR1 and BAK1 to mediate resistance against this fungus. It is proposed that phosphorylation events take place between the cytoplasmic kinase domains of SOBIR1 and BAK1, which lead to the initiation of various downstream signaling outputs such as the rapid phosphorylation of receptor-like cytoplasmic kinases (RLCKs), the accumulation of reactive oxygen species (ROS), the activation of mitogen-activated protein kinase (MAPK) cascades, and in some cases, the hypersensitive response (HR). Here, by performing in vitro phosphorylation assays, we show that SOBIR1 directly phosphorylates BAK1, whereas BAK1, in its turn, directly phosphorylates SOBIR1, which results in the full activation of the Cf-4-containing immune complex. We found that threonine 522, present in the activation segment of the SOBIR1 kinase domain of Nicotiana benthamiana (Nb), is required for its intrinsic kinase activity, and is essential for the Avr4/Cf-4/SOBIR1/BAK1-triggered ROS burst, MAPK activation and the HR. Tyrosine residue Y469 was found to be crucial for the Avr4/Cf-4- triggered activation of MAPKs and the HR, but not for ROS production and NbSOBIR1 intrinsic kinase activity. RLCKs are well-recognized to act as the initial cytoplasmic transducers, bridging cell-surface receptor complexes with their downstream signaling partners. By knocking out multiple genes belonging to different RLCK-VII subfamilies in N. benthamiana plants stably expressing Cf-4, we show that members of the RLCK-VII subfamilies 6, 7 and 8 are required for the Avr4/Cf-4-triggered ROS production. Typically, the Avr4 protein triggers a biphasic ROS burst in leaf discs obtained from N. benthamiana:Cf-4 plants, in which the first transitory response is followed by a second, sustained ROS burst. Interestingly, the intensities of the first and second phase of the ROS burst are affected in different ways in the various rlck-vii knock-out plants, indicating that there are different downstream ROS regulatory mechanisms, involving different RLCKs in N. benthamiana. Further studies show that members from RLCK-VII-6, 7 and 8 also play an essential role in regulating the ROS production triggered by flg22, chitin, and the nlp20/RLP23 and the pg13/RLP42 combinations.
Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining

The CK1 family are conserved serine/threonine kinases with numerous substrates and cellular functions. The fission yeast CK1 orthologues Hhp1 and Hhp2 were first characterized as regulators of DNA repair, but the mechanism(s) by which CK1 activity promotes DNA repair had not been investigated. Here, we found that deleting Hhp1 and Hhp2 or inhibiting CK1 catalytic activities in yeast or in human cells activated the DNA damage checkpoint due to persistent double-strand breaks (DSBs). The primary pathways to repair DSBs, homologous recombination and non-homologous end joining, were both less efficient in cells lacking Hhp1 and Hhp2 activity. In order to understand how Hhp1 and Hhp2 promote DSB repair, we identified new substrates using quantitative phosphoproteomics. We confirmed that Arp8, a component of the INO80 chromatin remodeling complex, is a bona fide substrate of Hhp1 and Hhp2 that is important for DSB repair. Our data suggest that Hhp1 and Hhp2 facilitate DSB repair by phosphorylating multiple substrates, including Arp8.
Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer

Copy number variations, and particularly duplications of genomic regions, have been strongly associated with various neurodegenerative conditions including autism spectrum disorder (ASD). These genetic variations have been found to have a significant impact on brain development and function, which can lead to the emergence of neurological and behavioral symptoms. Developing strategies to target these genomic duplications has been challenging, as the presence of endogenous copies of the duplicate genes often complicates the editing strategies. Using the ASD and anxiety mouse model Flailer, that contains a duplication working as a dominant negative for MyoVa, we demonstrate the use of DN-CRISPRs to remove a 700bp genomic duplication in vitro and in vivo. Importantly, DN-CRISPRs have not been used to remove more gene regions <100bp successfully and with high efficiency. We found that editing the flailer gene in primary cortical neurons reverts synaptic transport and transmission defects. Moreover, long-term depression (LTD), disrupted in Flailer animals, is recovered after gene edition. Delivery of DN-CRISPRs in vivo shows that local delivery to the ventral hippocampus can rescues some of the mutant behaviors, while intracerebroventricular delivery, completely recovers Flailer animal phenotype associated to anxiety and ASD. Our results demonstrate the potential of DN-CRISPR to efficiently (>60% editing in vivo) remove large genomic duplications, working as a new gene therapy approach for treating neurodegenerative diseases.
Interdependence of primary and secondary somatosensory cortices for plasticity and texture discrimination learning

Feedforward and feedback pathways are important for transfer and integration of information between sensory cortical areas. Here we find that two closely connected cortical areas, the primary (S1) and secondary somatosensory cortices (S2) are both required for mice to learn a whisker-dependent texture discrimination. Increased inhibition in either area (using excitatory DREADDs expressed in inhibitory interneurones) prevents learning. We find that learning the discrimination produces structural plasticity of dendritic spines on layer 2/3 pyramidal neurones in vibrissae S1 that is restricted to the basal dendrites and leaves dendritic spines on apical dendrites unchanged. As S2 projects to the apical dendrites of S1 neurones, we tested whether S2 affects LTP-induction in S1. We found that feedback projections from S2 to S1 gates LTP on feedforward pathways within S1. These studies therefore demonstrate the interdependence of S1 and S2 for learning and plasticity in S1. HIGHLIGHTS Both primary (S1) and secondary (S2) somatosensory cortices are necessary for whisker based texture discrimination learning S2 feedback connections to S1 gate LTP at feedforward pathways in S1 S1 undergoes structural plasticity of pre-existing spines during learning S1 learning induced plasticity and LTP occurs on basal but not apical dendrites