Miracle-dz/UniFAR-FTUs huggingface dataset:
Negative impact of insomnia and daytime sleepiness on quality of life in individuals with the cyclin‐dependent kinase‐like 5 deficiency disorder

Cyclin‐dependent kinase‐like 5 (CDKL5) gene pathogenic variants result in CDKL5 deficiency disorder (CDD). Early onset intractable epilepsy and severe developmental delays are prominent symptoms of CDD. Comorbid sleep disturbances are a major concerning symptom for families. We aimed to explore the relationship between insomnia, daytime sleepiness, sleep medications and quality of life in children with CDD. Caregivers of 129 children with CDD in the International CDKL5 Disorder Database completed the Quality‐of‐Life Inventory‐Disability (QI‐Disability) questionnaire and “Disorders of Maintaining Sleep” (DIMS) and the “Disorders of Excessive Somnolence” (DOES) items of the Sleep Disturbance Scale for Children. Adjusting for covariates, a unit increase in DOES score was associated with reduced quality of life total (coefficient −3.06, 95% confidence interval [CI] 1.35–7.80), physical health (coefficient −7.20, 95% CI −10.64, −3.76) and negative emotions (coefficient −3.90, 95% CI −7.38, −0.42) scores. Adjusting for covariates, a unit increase in DIMS score was associated with reduced negative emotions (coefficient −6.02, 95% CI −10.18, −2.86). Use of sleep medications had small influences on the effect sizes. This study highlights the importance of sleep problems as a determinant of quality of life in children with CDD, consistent with effects observed for other groups of children with intellectual disability. Excessive daytime sleepiness was particularly associated with detrimental effects on quality of life. Further research in optimal behavioural and pharmaceutical management of sleep problems for this population is required.
Hypnotherapy for persons with Irritable Bowel Syndrome: A three-arm randomized controlled trial

ABSTRACT The current study sought to (1) compare the efficacies of Ericksonian hypnotherapy, traditional hypnotherapy, and educational talk in treating irritable bowel syndrome (IBS), and to (2) evaluate the impacts of hypnotic susceptibility on participants’ responses to hypnotherapy. The study adopted a three-arm randomized controlled trial design and achieved an effective sample size of 144. Self-reported psychological questionnaires were used to assess participants’ IBS symptom severity, health-related quality of life, and coping patterns at baseline, immediately post-intervention, and 3 months after intervention. The evaluation focused primarily on IBS symptom severity and health-related quality of life, as well as on the illness coping patterns of symptom catastrophizing and symptoms-related social hypervigilance. The findings showed that significant improvements in IBS symptom severity occurred in all three types of study groups immediately after completion of the intervention (p < .05, ηρ 2 = .20). However, only the traditional hypnotherapy groups and the Ericksonian hypnotherapy groups still had a notably significant decrease in symptoms 3 months after the intervention, whereas the educational talk groups had dropped back to pre-treatment symptom levels at the 3-month follow-up. The amplitude of change of symptom catastrophizing in the traditional hypnotherapy groups was stronger than that in the Ericksonian hypnotherapy groups after completion of the intervention, and the two types of hypnotherapy groups were significantly lower in symptom catastrophizing both immediately after the intervention and also 3 months post-intervention (p < .001, ηρ 2 = .17). The other coping mechanism studied, symptoms-related social hypervigilance, showed a significant decline only in the Ericksonian hypnotherapy groups (ps < .001, ηρ 2 = .45). Interestingly, in the traditional hypnotherapy groups, persons with higher hypnotic susceptibility showed significant improvement in symptom severity, health-related quality of life, and coping patterns following treatment. Notably, the effects from Ericksonian hypnotherapy for IBS diverged from the effects from traditional hypnotherapy. Finally, both Ericksonian hypnotherapy and traditional hypnotherapy appeared to have greater positive effects than educational talk did, but at different levels.
A Mucin-Deficient Ocular Surface Mimetic Platform for Interrogating Drug Effects on Biolubrication, Antiadhesion Properties, and Barrier Functionality

Dry eye disease (DED) affects more than 100 million people worldwide, causing significant patient discomfort and imposing a multi-billion-dollar burden on global health care systems. In DED patients, the natural biolubrication process that facilitates pain-free blinking goes awry due to an imbalance of lipids, aqueous medium, and mucins in the tear film, resulting in ocular surface damage. Identifying strategies to reduce adhesion and shear stresses between the ocular surface and the conjunctival cells lining the inside of the eyelid during blink cycles is a promising approach to improve the signs and symptoms of DED. However, current preclinical models for screening ocular lubricants rely on scarce, heterogeneous tissue samples or model substrates that do not capture the complex biochemical and biophysical cues present at the ocular surface. To recapitulate the hierarchical architecture and phenotype of the ocular interface for preclinical drug screening, we developed an in vitro mucin-deficient DED model platform that mimics the complexity of the ocular interface and investigated its utility in biolubrication, antiadhesion, and barrier protection studies using recombinant human lubricin, a promising investigational therapy for DED. The biomimetic platform recapitulated the pathological changes in biolubrication, adhesion, and barrier functionality often observed in mucin-deficient DED patients and demonstrated that recombinant human lubricin can reverse the damage induced by mucin loss in a dose- and conformation-dependent manner. Taken together, these results highlight the potential of the platform—and recombinant human lubricin—in advancing the standard of care for mucin-deficient DED patients.
Clinical findings from the landmark MEF2C ‐related disorders natural history study

MEF2C‐related disorders are characterized by developmental and cognitive delay, limited language and walking, hypotonia, and seizures. A recent systematic review identified 117 patients with MEF2C‐related disorders across 43 studies. Despite these reports, the disorder is not easily recognized and assessments are hampered by small sample sizes. Our objective was to gather developmental and clinical information on a large number of patients.
Pharmacokinetics of glucagon after intravenous, intraperitoneal and subcutaneous administration in a pig model

There is increasing scientific evidence to substantiate using low‐dose glucagon as a supplement to insulin therapy in artificial pancreata for diabetes mellitus type 1. The delivery of both these hormones intraperitoneally would mimic normal physiology. However, our knowledge of the pharmacological properties of glucagon after intraperitoneal administration is limited. This study compared the pharmacokinetics of glucagon after intraperitoneal, subcutaneous and intravenous administration and the pharmacodynamic effects of glucagon on glucose metabolism after intraperitoneal and subcutaneous administration in a pig model.
Association between requests for supportive care assistance and patients' characteristics, prior to treatment in a comprehensive cancer center

Patients with cancer experience a wide array of distress symptoms (emotional, practical, physical, and functional), which often hinders their quality of life and survival. Unfortunately, only a small proportion of these patients request assistance for these problems. This study explored the relationship between requests for supportive care assistance and distress of patients newly diagnosed with cancer.
Electrochemical Capacitors with Confined Redox Electrolytes and Porous Electrodes

Electrochemical capacitors (ECs), including electrical‐double‐layer capacitors and pseudocapacitors, feature high power densities but low energy densities. To improve the energy densities of ECs, redox electrolyte‐enhanced ECs (R‐ECs) or supercapbatteries are designed through employing confined soluble redox electrolytes and porous electrodes. In R‐ECs the energy storage is based on diffusion‐controlled faradaic processes of confined redox electrolytes at the surface of a porous electrode, which thus take the merits of high power densities of ECs and high energy densities of batteries. In the past few years, there has been great progress in the development of this energy storage technology, particularly in the design and synthesis of novel redox electrolytes and porous electrodes, as well as the configurations of new devices. Herein, a full‐screen picture of the fundamentals and the state‐of‐art progress of R‐ECs are given together with a discussion and outlines about the challenges and future perspectives of R‐ECs. The strategies to improve the performance of R‐ECs are highlighted from the aspects of their capacitances and capacitance retention, power densities, and energy densities. The insight into the philosophies behind these strategies will be favorable to promote the R‐EC technology toward practical applications of supercapacitors in different fields.
Attention-Deficit/Hyperactivity Disorder and Outcome from Concussion: Examining Duration of Active Rehabilitation and Clinical Recovery

Abstract Aims The objective of this study was to compare recovery time and duration of active rehabilitation following concussion between adolescents with and without attention-deficit/hyperactivity disorder (ADHD). Methods A retrospective cohort study was conducted among adolescents presenting to a specialty concussion clinic. One-quarter of the eligible episodes of care were selected. The final sample included 540 adolescents (ages 13–17 years, median age 15 years; 49.8% girls), of which 65 (12.0%) had a pre-injury diagnosis of ADHD. Days to recovery and days of active rehabilitation were examined. Results ADHD was not associated with recovery time (ADHD: median = 49 days, IQR = 25–77; No ADHD: median = 47 days, IQR = 29–85) in univariate (Z = −0.45; p = 0.65) or multivariable analyses (Hazard Ratio: 1.17 (0.85–1.61); χ2(1) = 0.95; p = 0.33). The duration of active rehabilitation services received did not differ between youth with ADHD (median = 38.5 days, IQR = 27.5–54.5) and without ADHD (median = 37.5 days, IQR = 18.5–66) in univariate (Z = −0.19; p = 0.85) or multivariable analyses (Hazard Ratio: 1.04 (0.67–1.63); χ2(1) = 0.03; p = 0.85). Conclusions Our findings support accumulating evidence that ADHD, in and of itself, is not a risk factor for longer recovery or worse outcomes following pediatric concussion.
Effects of Sleep Restriction on Self-Reported Putting Performance in Golf

In the present study, we aimed to explore the effects of sleep restriction (SR) on self-reported golf putting skills. Eleven collegiate golfers participated in a self-reported, counterbalanced experimental study under two conditions: (a) a SR condition in which sleep on the night prior to putting was restricted to 4–5 hours, and (b) a habitual normal sleep (NS) condition on the night before the putting test. Following each sleep condition, participants engaged in ten consecutive putting tests at 7 am, 11 am, and 3 pm. Participants reported their subjective sleepiness before each time frame, and their chronotype, defined as their individual circadian preference, was scored based on a morningness–eveningness questionnaire (MEQ). Participants restricted sleep to an average period of 267.6 minutes/night (SD = 51.2) in the SR condition and 426.2 (SD =38.0) minutes/night in the NS condition. A two-way analysis of variance revealed a significant main effect of the sleep condition on the lateral displacement of putts from the target (lateral misalignment) (p = 0.002). In addition, there was a significant main effect of time on distance from the target (distance misalignment) (p = 0.017), indicating less accuracy of putting in the SR condition. In the SR condition, the MEQ score was positively correlated with distance misalignment at 3 pm (ρ = 0.650, p = 0.030), suggesting that morningness types are susceptible to the effects of SR on putting performance. Our findings suggest that golfers should obtain sufficient sleep to optimize putting performance.
Social facilitation effects in online coaction: the moderating role of social comparison direction

Online and face-to-face coactions are widely used work organization modes. This study aims to investigate the effect of social comparison direction on task performance when people coact online. A total of 40 individuals were recruited to participate in a 2 (coaction type: online and face to face) × 3 (social comparison direction: upward, downward and no comparison) × 2 (phase: pre-comparison and post-comparison) within-subject experiment. The participants performed visual search tasks while their response time and search accuracy rates were measured. Results showed that the participants were reported to perform faster when they coacted online than face to face. The upward comparison led to a stronger social facilitation effect than the downward and no comparison directions, either in online or face-to-face coaction. These findings provide practical implications in the design of coaction modes for groups and teams working remotely.
Synthetic vascular graft with spatially distinct architecture for rapid biomimetic cell organisation in a perfusion bioreactor

Access to lab-grown fully functional blood vessels would provide an invaluable resource to vascular medicine. The complex architecture and cellular makeup of native vessels, however, makes this extremely challenging to reproduce in vitro. Bioreactor systems have helped advanced research in this area by replicating many of the physiological conditions necessary for full-scale tissue growth outside of the body. A key element underpinning these technologies are 3D vascular graft templates which serve as temporary scaffolds to direct cell growth into similar cellular architectures observed in native vessels. Grafts further engineered with appropriate physical cues to accommodate the multiple cell types that reside within native vessels may help improve the production efficiency and physiological accuracy of bioreactor-grown vessel substitutes. Here, we engineered two distinct scaffold architectures into an electrospun vascular graft aiming to encourage the spatial organisation of human vascular endothelial cells (hCAECs) in a continuous luminal monolayer, co-cultured with human fibroblasts (hFBs) populating the graft wall. Using an electrospun composite of polycaprolactone and gelatin, we evaluated physical parameters including fibre diameter, fibre alignment, and porosity, that best mimicked the spatial composition and growth of hCAECs and hFBs in native vessels. Upon identifying the optimal scaffold architectures for each cell type, we constructed a custom-designed mandrel that combined these distinct architectures into a single vascular graft during a single electrospinning processing run. When connected to a perfusion bioreactor system, the dual architecture graft spatially oriented hCAECs and hFBs into the graft wall and lumen, respectively, directly from circulation. This biomimetic cell organisation was consistent with positive graft remodelling with significant collagen deposition in the graft wall. These findings demonstrate the influence of architectural cues to direct cell growth within vascular graft templates and the future potential of these approaches to more accurately and efficiency produce blood vessel substitutes in bioreactor systems.
OCT Evaluation of Marginal and Internal Interface Integrity of Class V Composite Restorations after 36 to 48 Months.

PURPOSE To compare a self-etch and a two-step etch-and-rinse adhesive in terms of internal and marginal composite-tooth bond failure separately on enamel and dentin/cement at 36-48 months after restoration placement using optical coherence tomography (OCT). MATERIALS AND METHODS Twenty-seven patients with two or three class V composite restorations of noncarious cervical lesions 36-48 months after placement were included. The one-step self-etch adhesive Futurabond M ([Voco] group SE, n = 25) and the two-step etch-and-rinse adhesive Solobond M ([Voco] group ER, n = 20) combined with the nanohybrid composite Amaris (Voco) were evaluated. The four-step etch-and-rinse adhesive Syntac classic combined with Tetric EvoCeram (Ivoclar Vivadent) served as the control (n = 18). Spectral-domain OCT (SD-OCT, 1310-nm center wavelength) was applied. Marginal gaps and internal interfacial adhesive defects were quantified in cross-sectional OCT images. Groups were statistically compared using the Friedman/Wilcoxon test (α = 0.05). RESULTS In enamel, nonsignificantly different percentages of marginal gap formation and internal interfacial adhesive defects were found between the groups (pi ≥ 0.258). In dentin/cement, SE showed significantly less marginal gap formation compared to ER (p < 0.001) and control (p = 0.001), and at the internal dentin-composite interface less adhesive defects were found compared to ER (p < 0.001) and control (p = 0.003). CONCLUSION The self-etch adhesive used in the current study appears recommendable for restoration of noncarious cervical lesions with composite.
Exendin-(9-39) Effects on Glucose and Insulin in Children With Congenital Hyperinsulinism During Fasting and During a Meal and a Protein Challenge

OBJECTIVE The aim of this study was to assess whether exendin-(9-39) will increase fasting and postprandial plasma glucose and decrease the incidence of hypoglycemia in children with hyperinsulinism (HI). RESEARCH DESIGN AND METHODS This was an open-label, four-period crossover study. In periods 1 and 2, the effect of three different dosing regimens of exendin-(9-39) (group 1, 0.28 mg/kg; group 2, 0.44 mg/kg; group 3, 0.6 mg/kg) versus vehicle on fasting glucose was assessed in 16 children with HI. In periods 3 and 4, a subset of eight subjects received either vehicle or exendin-(9-39) (0.6 mg/kg) during a mixed-meal tolerance test (MMTT) and an oral protein tolerance test (OPTT). RESULTS Treatment group 2 showed 20% (P = 0.037) increase in the area under the curve (AUC) of fasting glucose. A significant increase in AUC of glucose was also observed during the MMTT and OPTT; treatment with exendin-(9-39) resulted in 28% (P ≤ 0.001) and 30% (P = 0.01) increase in AUC of glucose, respectively. Fasting AUC of insulin decreased by 57% (P = 0.009) in group 3. In contrast, AUC of insulin was unchanged during the MMTT and almost twofold higher (P = 0.004) during the OPTT with exendin-(9-39) treatment. In comparison with vehicle, infusion of exendin-(9-39) resulted in significant reduction in likelihood of hypoglycemia in group 2, by 76% (P = 0.009), and in group 3, by 84% (P = 0.014). Administration of exendin-(9-39) during the OPTT resulted in 82% (P = 0.007) reduction in the likelihood of hypoglycemia. CONCLUSIONS These results support a therapeutic potential of exendin-(9-39) to prevent fasting and protein-induced hypoglycemia in children with HI.
Effects of high-dose versus low-dose proton pump inhibitors for treatment of gastrointestinal ulcer bleeding: a meta-analysis of randomized controlled trials

Background We performed a meta-analysis to compare the effects of high-dose (80 mg/day) versus low-dose (40 mg/day) proton pump inhibitors (PPIs) on gastrointestinal ulcer bleeding. Methods We retrieved studies of randomized controlled trials of PPIs administered according to different schedules for the treatment of gastrointestinal ulcer bleeding from Medline, Embase, Web of Science, Clinical Trials, and the Cochrane Database in April 2020. Results Nine randomized controlled trials including 2329 patients were included in this meta-analysis. There were no significant differences in the incidences of re-bleeding, operation intervention, postoperative mortality, and length of hospital stay between the low-dose and high-dose groups. However, the blood transfusion volume was significantly higher in the high-dose group. Conclusion Compared with low-does PPIs, high-dose PPIs had no effect on the incidence of re-bleeding, operation intervention, or postoperative mortality, and did not reduce hospital stay in patients treated with endoscopic hemostasis for gastrointestinal bleeding.
Bad company: Loneliness longitudinally predicts the symptom cluster of pain, fatigue, and depression in older adults

Pain, fatigue, and depression frequently co‐occur as a symptom cluster. While commonly occurring in those with cancer and autoimmune disease, the cluster is also found in the absence of systemic illness or inflammation. Loneliness is a common psychosocial stressor associated with the cluster cross‐sectionally. We investigated whether loneliness predicted the development of pain, fatigue, depression, and the symptom cluster over time.
Developing automatic recognition system of drill wear in standard laminated chipboard drilling process

The paper presents an automatic approach to recognition of the drill condition in a standard laminated chipboard drilling process. The state of the drill is classified into two classes: “useful” (sharp enough) and “useless” (worn out). The case “useless” indicates symptoms of excessive drill wear, unsatisfactory from the point of view of furniture processing quality. On the other hand the “useful” state identifies tools which are still able to drill holes acceptable due to the required processing quality. The main problem in this task is to choose an appropriate set of diagnostic features (variables), based on which the recognition of drill state (“useful” versus “useless”) can be made. The features have been generated based on 5 registered signals: feed force, cutting torque, noise, vibration and acoustic emission. Different statistical parameters describing these signals and also their Fourier and wavelet representations have been used for defining the features. Sequential feature selection is applied to detect the most class discriminative set of features. The final step of recognition is done by using three types of classifiers, including support vector machine, ensemble of decision trees and random forest. Six standard drills of 12 mm diameter with tungsten carbide tips were used in experiments. The results have confirmed good quality of the proposed diagnostic system.
Investigating the Psychometric Properties of the Persian Version of the Massachusetts Youth Screening Instrument (MAYSI-2)

This study was done to prepare a Persian version of the MAYSI-2 and investigate its psychometric properties among the adolescents of the Juvenile Correction and Rehabilitation Center in Mashhad. By available study sample 329 male adolescents were selected. The findings showed that the Cronbach’s alpha values for subscales were from . 74 to . 91. Compound reliability was also obtained in different scales between . 72 and . 98 indicating the optimal reliability of the scale. The CVR and CVI indicating the appropriate content validity. The results of CFA showed that the factor loading of the items was more than . 5. The scale had good structural validity. The GFI of . 90, IFI of . 91, and RMSEA of . 072 were all within the acceptable limits. Convergent and divergent validity indicators showed that the subscales benefited from the convergent validity. Our results showed that the Persian version of the MAYSI-2 had desirable psychometric properties. Therefore, it can be used for assessing mental health problems of juvenile delinquent and upcoming research.