Miracle-dz/UniFAR-FTUs huggingface dataset:
Dual carbon isotope characterization of total organic carbon in wintertime carbonaceous aerosols from northern India

Large‐scale emissions of carbonaceous aerosols (CA) from South Asia impact both regional climate and air quality, yet their sources are not well constrained. Here we use source‐diagnostic stable and radiocarbon isotopes (δ13C and Δ14C) to characterize CA sources at a semiurban site (Hisar: 29.2°N, 75.2°E) in the NW Indo‐Gangetic Plain (IGP) and a remote high‐altitude location in the Himalayan foothills (Manora Peak: 29.4°N, 79.5°E, 1950 m above sea level) in northern India during winter. The Δ14C of total aerosol organic carbon (TOC) varied from −178‰ to −63‰ at Hisar and from −198‰ to −1‰ at Manora Peak. The absence of significant differences in the 14C‐based fraction biomass of TOC between Hisar (0.81 ± 0.03) and Manora Peak (0.82 ± 0.07) reveals that biomass burning/biogenic emissions (BBEs) are the dominant sources of CA at both sites. Combining this information with δ13C, other chemical tracers (K+/OC and SO42−/EC) and air mass back trajectory analyses indicate similar source regions in the IGP (e.g., Punjab and Haryana). These results highlight that CA from BBEs in the IGP are not only confined to the atmospheric boundary layer but also extend to higher elevations of the troposphere, where the synoptic‐scale circulations could substantially influence their abundances both to the Himalayas and over the downwind oceanic regions such as the Indian Ocean. Given the vast emissions of CA from postharvest crop residue combustion practices in the IGP during early Northeast Monsoon, this information is important for both improved process and model understanding of climate and health effects, as well as in guiding policy decision aiming at reducing emissions.
Impact of Mars GDS 2018 on the Chemistry of Water, Nitrogenated and Deuterated Cluster Ions: NOMAD Observations

The ExoMars Trace Gas Orbiter instruments, Nadir and Occultation for Mars Discovery and Atmospheric Chemistry Suite have provided vertical profiles of H2O and HDO mixing ratios in the presence and absence of Global Dust Storm 2018. These observations are carried out in the lower atmosphere at SZA ∼ 71° of northern mid latitude (∼55°N, 130°E). Using NOMAD observations, we developed chemical models 1 and 2 for dust and non‐dust storm conditions, respectively. The production/loss rates of H2O, HDO and D2O and the densities of water, nitrogenated and deuterated cluster ions (H2O+, D2O+, HDO+, H+(H2O)n, D+(D2O)n, H+(HDO)n, CO4−, CO3−, CO3−(H2O)n, CO3−(D2O)n, CO3−(HDO)n, NO2−(H2O), NO2−(HDO), and NO2−(D2O) (for n = 1 to 5)) are estimated from these models between 10 and 70 km. We have used two ionization sources: (a) Galactic Cosmic Rays (GCR) and (b) hard X‐ray in both models. The D peak density produced by GCR is lower by a factor of ∼5 than that produced by the hard X‐rays. In model 1, the electron densities were increased by a factor of ∼2–3 than that produced by model 2. The estimated production/loss rates of H2O, HDO, and D2O are also larger by an order of magnitude in model 1 than that estimated by model 2.
Caledonian nappe geometry in north-central Sweden and basin evolution on the Baltoscandian margin

Abstract Structural analysis of the Lower Allochthon in the north-central Scandinavian Caledonides has allowed the construction of restorable cross-sections consistent with the development of a foreland-propagating linked thrust system. The internal geometry of an antiformal stack, the Njakafjäll duplex, within the Lower Allochthon demonstrates tectonic shortening of c. 50% and suggests an overall predeformational width for the Lower Allochthon in this area of at least c. 130 km, and possibly considerably greater if the buried trailing edge of the Lower Allochthon lies in a comparable position to that farther south in Tröndelag. These results, combined with a stratigraphic analysis of the imbricates within the Lower Allochthon and of the adjoining Autochthon and Middle Allochthon, indicate the development, from Proterozoic through Cambrian times, of two sedimentary basins on the c. 200 km wide continental margin of Baltica bordering the Iapetus Ocean. The basins were separated by a region of basement relief, the Børgefjell domain, above which a reduced sequence of Vendian to Cambrian rocks accumulated. This Børgefjell basement high, and the similar Njakafjäll basement high to the east, subsequently became the sites of antiformal stack development. It is argued that the frequent incorporation of basement into the thrust sheets, together with the thin sedimentary fill of these basins, compared with the much greater fill in basins to the south in Jämtland and to the north of Finnmark, implies major palaeogeographic changes along the Baltoscandian margin, possibly related to early rift geometries. The apparent lack of subsequent foreland basin development in north-central Scandinavia compared with areas to the south may indicate a deeper level of thrust detachment beneath the Middle Allochthon to the north, such that any foreland basin sediments have been removed in the hangingwall and subsequently eroded. An alternative possibility is a primary absence of foreland basin development that may relate to a differing response to thrust loading by continental lithosphere which had been variably thinned during the earlier rift regime.
Acute kidney injury and COVID-19 in young adults in intensive care

Objective To describe acute kidney injury prevalence in young adults diagnosed with COVID-19 admitted to the Intensive Care Unit. Methods This is a retrospective, quantitative and analytical study. The sample consisted of young adults (20 to 40 years old) admitted to Intensive Care Units, diagnosed with SARS-CoV-2 infection between March and December 2020. Data were obtained through electronic medical records, and kidney injury acute was defined by the creatinine value, according to the Kidney Disease Improving Global Outcomes guidelines criteria. Statistical significance was p≤0.05. Results A total of 58 young adults were hospitalized, 63.8% of whom were male. Hypertension was present in 39.6%, obesity in 18.9%, and diabetes mellitus in 8.6%. Acute kidney injury was identified in 55.1%, with stage 3 predominating in 43.1% of them. In these patients, the use of mechanical ventilation and vasoactive drugs was significant in 92% as well as respiratory organ dysfunction (80%), followed by renal organ dysfunction (76%). Risk factors such as kidney transplantation or chronic kidney disease and obesity increased by 12.3 and 9.0 times, respectively, the chances of developing acute kidney injury. Conclusion This study demonstrated a high kidney injury prevalence in young adults and its association with previous comorbidities. Obesity, kidney transplantation and chronic kidney disease increased the chance of young adults to develop acute kidney injury, resulting in outcomes in favor of morbidity and mortality.
Feasibility Study Of M-Health Transition Care Program For Traumatic Brain Injury Caregivers

Background: Caring in discharge transition for patients with moderate to severe traumatic brain injury (TBI) has impacted caregivers. MHealth has become popular for communication between a patient/caregiver and a health profession integrated into numerous public well-being programs in low-middle income countries but is limited for TBI caregivers. Purpose: This study aims to assess the feasibility of the mHealth supportive care transition program based on transitional care theory for improving discharge readiness and reducing caregivers' transition stress and burden of caregiving and the patient's readmission rate. Methods: Seven family caregivers who met inclusion criteria were recruited. The mHealth supportive care transition program includes education and face-to-face information assisted by an android-based application, skill demonstration, assessment of the readiness of hospital discharge, and weekly monitoring and follow-up after the patient's discharge is given. The outcomes were evaluated using a validated and standardized scale designed to measure transition stress and the burden of caregiving at the baseline, two weeks, and one-month post-discharge, including the patient's readmission one month (within 28 days) after discharge. Feedback through the mHealth satisfaction questionnaire on the trial feasibility was also collected. Results: The initial findings showed that all subjects experienced a decrease of stress transition and caregiver burden at two weeks and one-month post-discharge follow-up. High satisfaction scores on mHealth were also reported and no patient was readmitted within 28 days. Conclusion: This feasibility study showed the mHealth supportive care transition program is feasible for implementation, but it is required to test the effectiveness in the next phase on RCT with a larger sample size.
Gravity-based network traffic abstraction and laser ON/OFF control in optical satellite networks

As the cost of launching low Earth orbit satellites continuously decreases, satellite-based communications networks are emerging as a new area for both academia and industry. Lasers are already employed for building inter-satellite links, forming optical satellite networks. The orbiting nature of satellites determines that the optical satellite networks are usually uniformly distributed around the Earth, to provide seamless coverage to any place at all times. However, the end users on the Earth are non-uniformly distributed. As a result, many satellites with laser links might not be utilized efficiently. From the energy perspective, this work studies the energy-efficiency issues of the inter-satellite laser links. We first model the optical satellite networks by presenting the satellite constellation with inter-satellite laser design principles and introduce the laser ON/OFF control problem accordingly. To explore the possibility of saving energy in the massive satellite deployment, we further introduce the gravity-based network traffic model and propose a gravity-based network traffic abstraction (GNTA) model to evaluate the importance of each laser link. Accordingly, we further propose a GNTA-based ON/OFF control (GOOC) algorithm to improve the energy efficiency of inter-satellite laser links by switching OFF parts of the laser links that are less utilized. We evaluate the GOOC’s performance using simulation, and results show that switching OFF 20% of the laser terminals in the full-gridmesh topology can improve the energy efficiency by about 10%, with an acceptable cost of network performance degradation.
Further characterization of Shigella-specific (memory) B cells induced in healthy volunteer recipients of SF2a-TT15, a Shigella flexneri 2a synthetic glycan-based vaccine candidate

Shigellosis is common worldwide, and it causes significant morbidity and mortality mainly in young children in low- and middle- income countries. To date, there are not broadly available licensed Shigella vaccines. A novel type of conjugate vaccine candidate, SF2a-TT15, was developed against S. flexneri serotype 2a (SF2a). SF2a-TT15 is composed of a synthetic 15mer oligosaccharide, designed to act as a functional mimic of the SF2a O-antigen and covalently linked to tetanus toxoid (TT). SF2a-TT15 was recently shown to be safe and immunogenic in a Phase 1 clinical trial, inducing specific memory B cells and sustained antibody response up to three years after the last injection. In this manuscript, we advance the study of B cell responses to parenteral administration of SF2a-TT15 to identify SF2a LPS-specific B cells (SF2a+ B cells) using fluorescently labeled bacteria. SF2a+ B cells were identified mainly within class-switched B cells (SwB cells) in volunteers vaccinated with SF2a-TT15 adjuvanted or not with aluminium hydroxide (alum), but not in placebo recipients. These cells expressed high levels of CXCR3 and low levels of CD21 suggesting an activated phenotype likely to represent the recently described effector memory B cells. IgG SF2a+ SwB cells were more abundant than IgA SF2a + SwB cells. SF2a+ B cells were also identified in polyclonally stimulated B cells (antibody secreting cells (ASC)-transformed). SF2a+ ASC-SwB cells largely maintained the activated phenotype (CXCR3 high, CD21 low). They expressed high levels of CD71 and integrin α4β7, suggesting a high proliferation rate and ability to migrate to gut associated lymphoid tissues. Finally, ELISpot analysis showed that ASC produced anti-SF2a LPS IgG and IgA antibodies. In summary, this methodology confirms the ability of SF2a-TT15 to induce long-lived memory B cells, initially identified by ELISpots, which remain identifiable in blood up to 140 days following vaccination. Our findings expand and complement the memory B cell data previously reported in the Phase 1 trial and provide detailed information on the immunophenotypic characteristics of these cells. Moreover, this methodology opens the door to future studies at the single-cell level to better characterize the development of B cell immunity to Shigella.
Fano Resonances in Metal Gratings with Sub-Wavelength Slits on High Refractive Index Silicon

The enhancement of optical waves through perforated plates has received particular attention over the past two decades. This phenomenon can occur due to two distinct and independent mechanisms, namely, nanoscale enhanced optical transmission and micron-scale Fabry–Perot resonance. The aim of the present paper is to shed light on the coupling potential between two neighboring slots filled with two different materials with contrasting physical properties (air and silicon, for example). Using theoretical predictions and numerical simulations, we highlight the role of each constituent material; the low-index material (air) acts as a continuum, while the higher-index material (silicon) exhibits discrete states. This combination gives rise to the so-called Fano resonance, well known since the early 1960s. In particular, it has been demonstrated that optimized geometrical parameters can create sustainable and robust band gaps at will, which provides the scientific community with a further genuine alternative to control optical waves.
The effectiveness of mindful hypnotherapy on difficulties in emotion regulation, mindfulness, and mental health in patients with major depressive disorder

BACKGROUND: More than 300 million people are affected by major depressive disorder, and despite advances in treatments over the past 50 years, this number is increasing worldwide. Due to the high prevalence and increasing numbers, along with problems in various aspects of the patient's life, new effective treatments are essential in this field. MATERIALS AND METHODS: This study was a single-blinded randomized clinical trial. Thirty-four patients with major depressive disorder who were referred by clinical psychologists in the clinical psychology clinic of the Taleghani Hospital, Tehran, Iran, were selected by purposive sampling method and randomly assigned to the intervention and wait-list control groups. The Difficulties in Emotion Regulation Scale, the Five Facet Mindfulness Questionnaire, and the Mental Health Continuum Short Form were administered during the baseline and post treatment. Analyses of covariance and the repeated measures analysis of variance (ANOVA) procedure were performed to determine the difference between study groups. RESULTS: The results of the analysis of covariance and repeated measures ANOVA showed a clinically significant decrease in difficulties in emotion regulation and a significant increase in mindfulness and mental health in the intervention group (P < 0.001). The mean score (standard deviation) of the difficulties in emotion regulation scores was 123.75 (21.10) in the experimental group at baseline and significantly decreased to 76.19 (26.45) and 68.00 (22.83) after the intervention and two-month follow-up, respectively (P < 0.001). Additionally, the mean scores (standard deviation) for mindfulness and mental health were 93.06 (8.23) and 19.63 (7.92), respectively, at baseline and significantly increased to 149.43 (16.99) and 51.62 (9.78), respectively, after the intervention and to 144.18 (20.55) and 48.50 (13.52) after a two-month follow-up (P < 0.001). CONCLUSION: The results show that mindful hypnotherapy is an effective treatment for improving difficulties in emotion regulation, mindfulness, and mental health in patients with major depressive disorder.
Palynology of Cretaceous amber deposits of the Oriente Basin-Ecuador and the Eastern Cordillera-Colombia

Several Cretaceous amber-bearing localities were recently discovered, including the Oriente Basin of Ecuador (Hollín Formation), and the Eastern Cordillera of Colombia (Une Formation at La Popa mine). A palynological study of 48 samples was carried out to date them and assess their broad floristic content. We date the Hollín Formation as spanning the late Aptian to the early Albian based on the co-occurrence of Callialasporites trilobatus, Retitricolpites operculatus and Callialasporites dampieri, among others. The sandstone lens containing amber from Une Formation at La Popa mine were dated as latest Aptian to early Cenomanian based upon the co-occurrence of Callialasporites dampieri, Afropollis jardinus, Ischyosporites variegatus and Gnetaceaepollenites retangularis. The palynoflora is dominated by high spore diversity suggesting humid climate conditions in the northwestern margin of Gondwana.
Testing of rapid vigor method for sorghum (Sorghum bicolor L. Moench) by using radicle emergence

Sorghum has a higher protein nutrient content (11%) than rice (6.8%) per 100 grams of ingredients. However the development and yield of sorghum is still low. One of the causes of low sorghum production yields is because seed deteriorate rapidly. The deterioration of sorghum seeds during storage signals a low seed vigor. So it is necessary to improve seed vigor tests efficiency in order to shorten test time. The objective of this research are determining observation time of Radicle emergence test and determining correlation between Radicle emergence test results with vigor test and seed viability. The results showed that radicula observations using Radicle emergence method can be carried out after the seeds are germinated for 96 hours at 25 + 2 0C temperature. The second result show there is positive correlation between Radicle emergence value to the vigor test and viability seed such as Vigor Index, Speed of Germination, Germination Seed, Maximum Growth Potential. It means the higher value of Vigor Index, Speed of Germination, Germination Seed, Maximum Growth Potential, the higher Radicle emergence value. The correlation between Radicle emergence and Mean Germination Time and Sprout Growth Rate changes shows a negative correlation.
A Relative Age Effect (RAE) analysis of top European football clubs segmented by ownership models

Abstract The aim of this paper is to analyse the Relative Age Effect (RAE) on European elite football teams segmented by type of ownership. The study presents the RAE incidence in the Academy of the UEFA top 10 ranking clubs near the conclusion of the 2020–21 season. The sample (n = 746) comprises players aged 17 to 23 years of age. The frequency of the players’ date of birth adjusting to a Poisson regression was used in order to confirm the presence of RAE. The existence of RAE in the whole sample was verified (p < 0.001). By segmenting the sample, the existence of RAE in the analysed age range between U17–19 and U20–23 (p < 0.001) was confirmed. Whereas listed clubs, clubs owned by private shareholders and clubs owned by members had a very significant RAE incidence (p < 0.001), clubs owned by public organisations did not present RAE. Results suggest that the management of youth academies differs depending on the ownership model.
Alizarin, an Agonist of AHR Receptor, Enhances CYP1A1 Enzyme Activity and Induces Transcriptional Changes in Hepatoma Cells

The phytopigment alizarin was previously characterized as an anti-tumor drug owing to its antioxidant or antigenotoxic activities. However, the safety of alizarin is currently still under dispute. In this study, we explored the activity of alizarin in the AHR-CYP1A1 pathway and analyzed the transcriptional changes affected by alizarin using human hepatoma cell line HepG2-based assays. The results showed that alizarin decreased HepG2 cell viability in a dose-dependent manner, with IC50 values between 160.4 and 216.8 μM. Furthermore, alizarin significantly upregulated the expression of CYP1A1 and increased the ethoxyresorufin-O-deethylase activity. Alizarin also exhibited agonistic activity toward the AHR receptor in the XRE-mediated luciferase reporter gene assay, which was further confirmed via the molecular docking assay. In addition, the transcriptional analysis indicated that alizarin may act as a potential carcinogen through significantly enriching several items related to cancer in both DO and KEGG analysis. In brief, our findings indicated that alizarin shows agonistic activities to the AHR receptor through activating the AHR-CYP1A1 signaling pathway in HepG2 cells, which may lead to the risks for cancer developing.
UvA-DARE ( Digital Academic Repository ) Norms of online expressions of emotion : Comparing Facebook

The main aim of this study was to examine the norms of expressing emotions on social media. Specifically, the perceived appropriateness (i.e. injunctive norms) of expressing six discrete emotions (i.e. sadness, anger, disappointment, worry, joy, and pride) was investigated across four different social media platforms. Drawing on data collected in March 2016 among 1201 young Dutch users (15–25 years), we found that positive expressions were generally perceived as more appropriate than negative expressions across all platforms. In line with the objective of the study, some platform differences were found. The expression of negative emotions was rated as most appropriate for WhatsApp, followed by Facebook, Twitter, and Instagram. For positive emotion expression, perceived appropriateness was highest for WhatsApp, followed by Instagram, Facebook, and Twitter. Additionally, some gender differences were found, while age showed little variations. Overall, the results contribute to a more informed understanding of emotion expression online.