Miracle-dz/UniFAR-FTUs huggingface dataset:
A role for astroctye-related genes in suicide

Astrocytes are the most abundant cell-type in the nervous system, yet are perhaps the least acknowledged players in brain function. Long considered support cells or ‘glue’, astrocytes are gradually being recognized as integral not only to the cytoarchitecture and the inflammatory process, but also to cell signaling and synaptic plasticity. This thesis will describe how a network of astrocyte-related genes may play a role in suicide. Through global gene expression analysis, a network of astrocyte-related genes was identified in brain of suicide completers as down-regulated compared to people who did not die by suicide. In particular, we identified an astrocyte-expressed TrkB gene, whose reduction of expression in suicide brain seems partially accounted for by epigenetic mechanisms. Finally, we investigated an astrocyte-expressed transcription factor, Sox9, that may partially regulate this astrocyte-related gene network. This work identifies a novel contributor to suicide, namely astrocyte dysfunction, which may impact behavior and mood. %%%%Les cellules en plus grand nombre dans le systeme nerveux sont les astrocytes, mais leur role dans le fonctionnement du cerveau demeure nebuleux. Longtemps considerees comme des cellules de support permettant a plusieurs types cellulaires d'interagir entre eux, les astrocytes sont desormais mieux reconnues comme faisant partie integrale de la cytoarchitecture du cerveau et de la plasticite neuronale. Cette these decrira le role que jouent les genes astrocytaires sur le suicide. Par une analyse de l'expression genetique globale, des genes astrocytaires ont ete identifies dans le cerveau de personnes decedees par suicide qui presentaient un niveau d’expression beaucoup plus faible chez les suicidaires que chez les sujets controles decedes de causes naturelles. Plus particulierement, la variante astrocytaire du gene du recepteur trkB, dont l’expression est significativement reduite dans les cerveaux des suicidaires, semble etre partiellement sous controle de mecanismes de regulation epigenetiques. Finalement, nous avons examine l’implication du facteur de transcription astrocytaire sox9 dans la regulation partielle de l’expression de la variante astrocytaire du recepteur trkB et dans la formation des reseaux neuronaux. Pour conclure, cet ouvrage identifie un nouveau marqueur du suicide, notamment ladysfonction astrocytaire, comme ayant un role predominant dans la regulation de l'humeur et la susceptibilite au suicide.
Antibacterial activity and mechanism of recombinant human - defensin 5 against clinical antibiotic-resistant strains

The increasing clinical bacterial strains resistant to conventional antibiotics have being a great challenge to the public’s health. As a novel kind of antimicrobial agent, defensins are undoubtedly worthy of exploitation for the treatment of antibiotic-resistant bacteria. To evaluate the antibacterial potency of recombinant mature human �-defensin 5 (rmHD5) against clinical pathogenic strains, we examined its antibacterial kinetics and bactericidal efficacy on forty-nine bacterial strains (belonging to eleven species) with different antibiotic-resistant phenotypes, isolated from digestive and urogenital tracts of the inpatient. Meanwhile, the action mechanism of rmHD5 was analyzed by transmission electron microscopy observation and membrane permeability detection. The peptide of rmHD5 was found to possess high potency against all the tested isolates at concentrations of 6 - 12 �g/ml for gramnegative (G
Participation and Media| Citizens Beyond Troika: Media and Anti-Austerity Protests in Portugal

The evolution of Portuguese civil society after the postrevolution period (1974) is framed in a normalization of the concept of democracy, significantly reducing civic participation. In a period of severe austerity (2011‒14), civic and social movements emerged strongly in Portuguese society and organized protests throughout the country and abroad. Anchored to the values of the Carnation Revolution, civil society took to the streets to claim the end of austerity. In September 2012, the government withdrew one of the proposed austerity measures after a million demanded it in the largest demonstration since the time of the April Revolution. This article analyzes and discusses the representations of the protests and activists in mainstream digital media and how social movements used Facebook to engage with different publics and promote civic participation.
The polyphyletic nature of Apanteles Foerster (Hymenoptera: Braconidae): a phylogeny and reclassification of Microgastrinae

The subfamily Microgastrinae is redefined; Cardiochilinae and Miracinae are placed as separate subfamilies. The Microgastrinae are divided into five tribes and 51 genera, 23 of which are new. The first two tribes, Apantelini and Microgastrini, have characteristically long ovipositor and are almost all solitary parasites of Microlepidoptera. The other three tribes, Forniciini, Cotesiini and Microplitini, have short ovipositor and are almost all parasites of Macrolepidoptera, usually gregarious. The genera Pseudapanteles , Parapanteles , Glyptapanteles and Protapanteles of Ashmead, Cotesia Cameron, Dolichogenidea and Diolcogaster Viereck are revived from synonymy, and the following new genera are described: Alphomelon , Choeras , Clarkinella , Deuterixys , Distatrix , Exix , Exoryza , Exulonyx , Iconella , Illidops , Nyereria , Papanteles , Paroplitis , Pelicope , Pholetesor , Rasivalva , Rhygoplitis , Sathon , Teremys , Venanides , Venanus , Wilkinsonellus , Xenogaster . Twenty new species are described and about 350 new combinations are given.
The Effectiveness of Family-Supportive Supervisors: The Moderating Role of Employees’ Collectivistic Self-Construal

Built upon conservation of resource theory and self-determination theory, this study explores boundary conditions under which family-supportive supervisors (FSSs) influence employee-perceived leader–member exchange (LMX) and work–family enrichment (WFE). Findings from this research reveal that FSSs positively relate to employee perceptions of LMX and WFE. Employees’ collectivistic self-construals moderate the effect of FSSs on LMX but not on WFE. Implications and future research directions are discussed.
MATING MANAGEMENT OF SOWS

Four mating systems were compared in two experiments and herd records were examined to compare sows mated once or twice under a system of planned double mating. In the first experiment, 100 sows were allocated to each of three systems: (i) double mating at 24-hour intervals, (ii) double mating 6-hour intervals, (iii) triple mating in a 24-hour period. Differences in farrowing ratio and litter size showed a small but not significant advantage in favour of triple mating. The farrowing ratios were 90, 89 and 93%, respectively. In the second experiment two systems were compared: (i) double mating at 24-hour intervals and (ii) single mating at the optimum time as indicated by changes in the vaginal mucosa. One hundred and sixty sows were allocated to each treatment. Differences in farrowing ratio and litter size were small and not significant. Herd records for a 5-year period were used to compare performance of sows mated once or twice under a system of planned double mating. Sows mated once under this system farrowed fewer pigs (p < 0.05) and had a lower farrowing ratio (p < 0.10) (77% vs 86%). Measurements made on duration of mating showed very great variation among boars and even between matings by the same boar. Duration of mating was not influenced by parity of sow, breed of boar or the amount of sexual activity by the boar during the previous week. Neither did duration of mating have any clear relationship with litter size. Litter size was poorly related to boar usage, but there was an indication that boars rested for over 7 days before mating produced larger litters.
Antimicrobial Activity and Composition of Hyptis mutabilis Essential Oil

ABSTRACT An analysis of the hydrodistilled essential oil from fresh aerial parts of Hyptis mutabilis (Rich) Briq. by GC/MS resulted in the identification of 24 compounds that represented 95.5 percent of the oil. The main constituents of the oil were E-caryophyllene (14.7%), spathulenol (14.2%) and germacrene D (11.1%). The oil exhibited significant antimicrobial activity against Mucor sp.
Modelling the occurrence of rainbow lorikeets (Trichoglossus haematodus) in Melbourne

Over the previous three decades, the rainbow lorikeet (Trichoglossus haematodus Family Psittacidae) has increased in urbanized areas of Australia. To help understand the nature of this increase, we investigated the influence of road density, tree cover and season on the occurrence of the rainbow lorikeet in the Melbourne region. Bayesian logistic regression was used to construct models to predict the occurrence of rainbow lorikeets, using Birds Australia atlas data at 207 2-ha sites. The results demonstrate a strong relationship between tree cover and urbanization and the distribution of the species. The best model incorporated quadratic terms for road density and tree cover, and interaction terms, as well as season as a categorical variable. Probability of occurrence of rainbow lorikeets was highest at medium tree cover (40% to 70% of the site covered) and medium road density (9% to 12% of the surrounding area covered by roads). There was a close correspondence between the predictions of the model and new observations from bird surveys conducted at randomly selected field sites. The increased abundance of the species in urban areas has occurred despite a paucity of hollows that would act as suitable nesting sites, suggesting that only a small proportion of the population is breeding in these areas.
The ronquils: a review of the North Pacific fish family Bathymasteridae (Actinopterygii: Perciformes: Zoarcoidei)

ABSTRACT The fish family Bathymasteridae, commonly known as ronquils, is reviewed based on an examination of nearly 500 adult and larval specimens. An identification key based on adults is provided. Information on adult morphology, including a detailed description of the cephalic lateralis system for all members of the family, is included as well as information on the early life history stages of each genus. The family Bathymasteridae is distinguished within the suborder Zoarcoidei by the presence of ctenoid scales; well-developed pelvic bones and pelvic fins; numerous vomerine, palatine, and dentary teeth; and several internal osteological features. The Bathymasteridae includes seven species classified in the genera Ronquilus, Rathbunella, and Bathymaster, and is broadly distributed in the North Pacific, from Baja California to the Sea of Japan. The monotypic genus Ronquilus is found from southern California to the Gulf of Alaska. Rathbunella contains two species restricted to the coasts of California and Baja California. Bathymaster is the most diverse and broadly distributed genus, containing four species ranging from British Columbia around the Pacific Rim to the northern Sea of Japan.
New perspectives on the biosynthesis, transportation, astringency perception and detection methods of grape proanthocyanidins

Abstract Proanthocyanidins (PAs) are important secondary metabolites crucial for the quality of grape berry and wine. Despite important advances in our understanding of the structural and regulatory genes involved in the PAs biosynthesis pathway, our knowledge about the details of biosynthetic and regulatory networks, especially the mechanism of polymerization and transportation remains limited. We provided an overview of the latest discoveries related to the mechanisms of grape PAs structure, astringency properties, detection methods, biosynthesis and transportation. We also summarized the environmental influencing factors of PAs synthesis in grape. Future trends were discussed.
SPATIAL ECOLOGY OF COYOTES ALONG A SUBURBAN-TO-RURAL GRADIENT

Abstract Coyotes (Canis latrans) are now ubiquitous throughout most of the eastern United States; however, little information exists on how they are able to exploit and thrive in fragmented landscapes. We investigated home ranges, movements, and scale-dependent resource selection of coyotes along a gradient (suburban/exurban/rural) of anthropogenic disturbance. Home-range sizes varied along a suburban-to-rural gradient and were inversely correlated to urbanization (R2 = 0.79, P < 0.001). Habitat composition and coyote use of 95% (home range) and 50% (core area) contours were nonrandom. Coyotes used corridor habitat extensively and avoided urban and crop-field habitats. Forested habitat was used extensively for diurnal cover. Rural coyotes traveled greater distances at faster rates than did suburban/exurban coyotes. Diel activity patterns were similar along the gradient, suggesting that coyotes responded similarly to differing levels and types of human activity. Coyotes appeared to assess habitat quality at the landscape scale and exploited small, disjunct resource patches present in developed landscapes. We believe that the availability of foraging habitat and travel corridors is critical to movement of coyotes in areas of high human activity.
Phytoliths as Emerging Taxonomic Tools for Identification of Plants: An Overview

In the recent advancements in identification of plant species, phytoliths have found an immense role in the identification of plants at different levels of taxonomic hierarchy. Many plant groups are known to accumulate silica in solid form in and between the cells and tissues and hence create the structures commonly known as phytoliths. These phytoliths create replicas of the structures where they are deposited. The shapes of phytolith replicas, their size dimensions (morphometric parameters), surface features (ornamentation), distribution, and orientation pattern in epidermal layers of vegetative and reproductive structures as well as their frequency are highly important for characterization of species. Monocotyledonous families particularly the family Poaceae (Gramineae) are known to produce diverse phytolith types that can serve as diagnostic markers for characterization of different taxa at different levels of taxonomic hierarchy. The present paper highlights the importance of phytoliths in taxonomic analysis of plants particularly in the family Poaceae.
DISTINGUISHING COEFFICIENT DRIVEN SENSITIVITY ANALYSIS OF GRA MODEL FOR INTELLIGENT DECISIONS: APPLICATION IN PROJECT MANAGEMENT

The Distinguishing Coefficient (ξ) is an important parameter of Grey Relational Analysis (GRA), a flagship multi-criteria decision making (MCDM) model of Grey System Theory, an intelligent and multifaceted field developed by Chinese scientists in 1980s. However, the scholars widely assume ξ = 0.5. The current study questions this practice. Also, some scholars have argued that the variation in ξ doesn’t influence the ranking of the factors through GRA. On contrary, the study demonstrates, the variation in ξ can influence the ranking. This has been shown through a case involving primary data concerning the perceived relative importance of Project Management Knowledge Areas (PMKAs). This study is significant for the analysts of uncertain systems, represented by grey or fuzzy systems, who intend to use GRA for intelligent multi-criteria decision making. It encourages ξ – driven sensitivity analysis of GRA model before interpreting the results. The study reveals, by tailoring the value of ξ a point can be achieved where the ranking obtained through GRA can be made most comparable to the other MCDM methods. For comparative analysis of the GRA based results the study deployed three other MCDM techniques; Analytic Hierarchy Process, Best Worst Method and Simple Additive Weighting.
Impact of the COVID-19 pandemic on the core functions of primary care: will the cure be worse than the disease? A qualitative interview study in Flemish GPs

Objectives The current COVID-19 pandemic, as well as the measures taken to control it, have a profound impact on healthcare. This study was set up to gain insights into the consequences of the COVID-19 outbreak on the core competencies of general practice, as they are experienced by general practitioners (GPs) on the frontline. Design, setting, participants We performed a descriptive study using semistructured interviews with 132 GPs in Flanders, using a topic list based on the WONCA definition of core competencies in general practice. Data were analysed qualitatively using framework analysis. Results Changes in practice management and in consultation strategies were quickly adopted. There was a major switch towards telephone triage and consults, for covid-related as well as for non-covid related problems. Patient-centred care is still a major objective. Clinical decision-making is largely focused on respiratory assessment and triage, and GPs feel that acute care is compromised, both by their own changed focus and by the fact that patients consult less frequently for non-covid problems. Chronic care is mostly postponed, and this will have consequences that will extend and become visible after the corona crisis. Through the holistic eyes of primary care, the current outbreak—as well as the measures taken to control it—will have a profound impact on psychological and socioeconomic well-being. This impact is already visible in vulnerable people and will continue to become clear in the medium and long terms. GPs think that they are at high risk of getting infected. Dropping out and being unable to contribute their part or becoming virus transmitters are reported to be greater concerns than getting ill themselves. Conclusions The current times have a profound impact on the core competences of primary care. Although the vast increase in patients soliciting medical help and the necessary separate covid and non-covid flows have been dealt with, GPs are worried about the continuity of regular care and the consequences of the anticovid measures. These may become a threat for the general health of the population and for the provision of primary healthcare in the near and distant future.
Prey Preference and Diet of Neonate Eastern Massasaugas (Sistrurus c. catenatus)

Abstract Because prey acquisition in young organisms often has profound effects later in life, understanding the foraging ecology of early age classes is important. We examined diet and prey preference of neonate Eastern Massasaugas (Sistrurus c. catenatus) at Carlyle Lake, Clinton County, Illinois. Prey recovered from free-ranging neonates consisted primarily of southern short-tailed shrews (Blarina carolinensis). In feeding trials, neonates demonstrated a preference for snake prey, disinterest in anuran and insect prey and indifference toward mammal prey. Because of gape limitations, neonates may have difficulty ingesting small mammals, but snakes are comparably easier to ingest and are the most common prey item of young S. c. catenatus in other parts of their range. Blarina carolinensis has not been reported previously from the diet of S. c. catenatus as their ranges overlap only in southwestern Illinois. Blarina carolinensis is considerably smaller than most mammals preyed upon by older age classes and would be easier for neonates to ingest. Thus, at Carlyle Lake, snakes may not be as important a prey resource for neonate massasaugas as in other parts of their range due to the availability of B. carolinensis.
Myelodysplastic syndrome with clonal karyotype evolution associated with trisomy 8 and ASXL1 mutation in well‐controlled HIV patient: Case report and literature review

To the Editor Nonspecific myelodysplastic features (MDF) due to hematopoietic effects of the human immunodeficiency virus (HIV) were frequent before the antiretroviral therapy (ART) era. Pronounced hypocellularity, plasmacytosis, and eosinophilia were observed and are referred to as HIVmyelopathy [1,2]. TheseMDF alterations generally resolve with the institution of ART. They should be separated from myelodysplastic syndrome (MDS), a heterogeneous groupofmyeloid clonal diseases. Myelodysplastic syndromes can have a primary cause, also called de novo MDS, or secondary (sMDS), both with the risk of progression to acutemyeloid leukemia (AML). Some case reports and small case series of MDS in well-controlled HIV patients were described [3-6]. Herein, a new case of a long-stand well-controlled HIV infected patient with MDS is reported. The MDS status evolved with clonal karyotype associated with trisomy 8 and ASXL1mutation. A 61-year-old black woman was diagnosed with HIV in 2002, and ART—Zidovudine, Lamivudine (3TC), and Efavirenz—was initiated. She remained on this treatment for 16 years with long-term suppressed viral load, and CD4 cell counts >600 cells/mm3. In January 2018, she presented with progressive anemia and mental depression and the scheme was switched to Tenofovir, 3TC, and Dolutegravir. In September 2018, she developed severe anemia and thrombocytopenia (hemoglobin [Hb] 4.3 g/dL, leucocyte 8.7 × 109/L, neutrophils 2.2 × 109/L, and platelets 45 × 109/L, reticulocyte 0.13%, and serum ferritin 1225 μg/L) with red blood cell transfusion dependency. The polymerase chain reaction for Parvovirus B19 was negative on the blood sample. Bone marrow (BM) aspiration and biopsy were performed. The morphology disclosed a BM hypercellular with multilineage dysplasia (80%) and blast cells (5%). The histology was characterized by erythroid reduction and granulocytic hyperplasia with increased precursor cells and abnormal localization of immature precursors (ALIP). No acid-fast or fungal microorganisms were observed. The G-banding of BM cells identified the karyotype: 47,XX,+8[5]/46,XX[9] (Figure 1A), and the fluorescence in situ hybridization (FISH) analysis confirmed the trisomy 8 (Figure 1B). ASXL1 andDNMT3A somatic mutations were tested by Sanger sequencing [7,8]. DNMT3A was wild type, and ASXL1mutation in exon
The effect of formaldehyde treatment of soya-bean meal and rapeseed meal on the amino acid profiles and acid-pepsin solubility of rumen undegraded protein

SUMMARY Soya-bean meal and rapeseed meal treated with 0, 0·4 or 0·8 g formaldehyde/100 g crude protein (N × 6·25) was incubated in the rumen in nylon bags with 10 and 40 μm aperture. Disappearance of dry matter and nitrogenous compounds was reduced with increasing formaldehyde treatment. The proportion of acid-pepsin soluble nitrogen in the undegraded residues of untreated and treated soya-bean meal was similar to the original samples. For rapeseed meal the proportion of acid-pepsin soluble nitrogen in the undegraded residues decreased with increasing rumen incubation time. This reduction decreased with increasing formaldehyde treatment. Concentration of amino acids in the undegraded residues did not generally deviate from those in the original samples. However, a distinguishable decrease in the methionine concentration was observed in all the rapeseed meal samples and in glutamic acid concentration in rapeseed meal treated with 0 and 0·4 g formaldehyde/100g- crude protein. Most of the changes due to rumen incubation were smaller using the 10 μm bags than using the 40 μm bags. However, the bag pore size did not play a decisive role in the conclusions of the results given.
Using Molecular Sexing to Assess Field-based Sexing Techniques in the Madagascar Fish-Eagle

Uso De Metodos Moleculares Para Evaluar Las Tecnicas De Campo Para Determinar El Sexo En Haliaeetus vociferoides Las tecnicas de campo para determinar el sexo de individuos adultos de la especie Haliaeetus vociferoides han incluido datos del peso corporal, la frecuencia de las vocalizaciones y la posicion durante la copula. Pusimos a prueba la confiabilidad de dichas tecnicas empleando metodos moleculares de determinacion del sexo en 43 individuos marcados. Demostramos la confiabilidad del uso del peso corporal y las frecuencias de las vocalizaciones para determinar el sexo con exactitud en el campo, y la poca confiabilidad del uso de la postura durante la copula. [Traduccion del equipo editorial]