Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of osimertinib in a metastatic lung adenocarcinoma patient harboring somatic EGFR delL747_S752 and germline BIM deletion polymorphism: a case report and literature review

Background Epidermal growth factor receptor (EGFR) exon 19 deletion (19del) and the exon 21 L858R point mutation are the most established predictive factors for the efficacy of EGFR-tyrosine kinase inhibitor (TKI) in patients with non-small cell lung cancer (NSCLC). To date, more than 50 subtypes of EGFR 19dels have been documented in NSCLC. Evidence suggests that different subtypes of 19dels exhibit different survival outcomes to EGFR-TKI treatment. Whether patients harboring EGFR Leu747_Ser752 deletion (delL747_S752) as an uncommon subtype of 19dels benefit from EGFR-TKIs has not been investigated. BIM (B-cell chronic lymphocytic leukemia/lymphoma-like 1) deletion polymorphism is common in East Asian with EGFR-mutant NSCLC. Currently, the predictive role of BIM deletion polymorphism in patients with EGFR-mutant NSCLC treated with osimertinib remains debatable. Case Description A 34-year-old female patient was diagnosed with stage IV lung adenocarcinoma (LUAD) harboring somatic EGFR del L747_S752 and germline BIM deletion polymorphism in August 2018. She obtained benefit from the front-line treatment of osimertinib lasting for 8 months. After progression from osimertinib, the patient received bevacizumab combined with platinum-doublet chemotherapy, stereotactic radiosurgery plus osimertinib and crizotinib, anlotinib, and a programmed cell death-1 inhibitor sintilimab plus bevacizumab and docetaxel. She succumbed to her disease in June 2020 with an overall survival of 23 months. Conclusions Our work suggests that osimertinib might be a compromised treatment option for NSCLC patients with somatic EGFR delL747_S752 and germline BIM deletion polymorphism. Development of more effective regimens are needed for this small subset of NSCLCs.
Torquigener flavimaculosus Hardy & Randall, 1983 (Actinopteri: Tetraodontidae), a junior synonym of Torquigener hypselogeneion (Bleeker, 1852) based on molecular and morphological data

Torquigener flavimaculosus Hardy & Randall (1983) was described based on specimens collected from the Gulf of Aqaba, Gulf of Suez, and Gulf of Aden, which has then penetrated the Mediterranean Sea, becoming one of the most abundant invasive tetraodontids. A comparison of samples collected from the northern Levant coasts of Türkiye between 2007 and 2020 showed that morphometric and meristic characteristics do not fully match either with T. flavimaculosus, or the closely related congeneric species T. hypselogeneion and T. altipinnis. Multivariate analysis carried out by 16 morphometric and six meristic characters did not show any discrimination between the above-mentioned species and exhibited almost identical sequences in genetic analysis. The results strongly suggest that T. flavimaculosus and T. hypselogeneion are conspecific, making the former species a junior synonym of the latter.
Don’t Forget the Bones: Incidence and Risk Factors of Metabolic Bone Disease in a Cohort of Preterm Infants

Metabolic bone disease of prematurity (MBD) is a condition of reduced bone mineral content (BMC) compared to that expected for gestational age (GA). Preterm birth interrupts the physiological process of calcium (Ca) and phosphorus (P) deposition that occurs mostly in the third trimester of pregnancy, leading to an inadequate bone mineralization during intrauterine life (IUL). After birth, an insufficient intake of Ca and P carries on this alteration, resulting in overt disease. If MBD is often a self-limited condition, in some cases it could hesitate the permanent alteration of bone structures with growth faltering and failure to wean off mechanical ventilation due to excessive chest wall compliance. Despite advances in neonatal intensive care, MBD is still frequent in preterm infants, with an incidence of 16–23% in very-low-birth-weight (VLBW, birth weight <1500 g) and 40–60% in extremely low-birth-weight (ELBW, birth weight <1000 g) infants. Several risk factors are associated with MBD (e.g., malabsorption syndrome, parenteral nutrition (PN), pulmonary bronchodysplasia (BPD), necrotizing enterocolitis (NEC), and some chronic medications). The aim of this study was to evaluate the rate of MBD in a cohort of VLBWI and the role of some risk factors. We enrolled 238 VLBWIs (107 male). 52 subjects were classified as increased risk (G1) and 186 as standard risk (G2) according to serum alkaline phosphatase (ALP) and phosphorus (P) levels. G1 subjects have lower GA (p < 0.01) and BW (p < 0.001). Moreover, they need longer PN support (p < 0.05) and invasive ventilation (p < 0.01). G1 presented a higher rate of BPD (p = 0.026). At linear regression analysis, BW and PN resulted as independent predictor of increased risk (p = 0.001, p = 0.040, respectively). Preventive strategies are fundamental to prevent chronic alteration in bone structures and to reduce the risk of short stature. Screening for MBD based on serum ALP could be helpful in clinical practice to identify subjects at increased risk.
INDONESIAN BANKING PERFORMANCE OF PRE AND POST OF MERGERS AND ACQUISITIONS

The objective of this study to analyse the performance of banks before and after conducting Mergers and Acquisitions (M&A) using a risk approach and how it affects the value of banking companies. Banking performance was analysed from three years before and three years after conducting mergers and acquisitions. To analyse the impact of banking mergers and acquisitions on company value, paired sample t-test and the fixed effect model (FEM) and Random Effect Model (REM) are utilised to test the research hypothesis. The results show that the banking performance after conducting M&A is decreased. This is demonstrated by the improvement in banking value and performance by using variables PBV, Tobin’s q, LDR and COMIN, which increase relatively after mergers and acquisitions, but the ability to generate profits, as measured by ROA is decreased.This is an implication of the combination of large assets that have not been used optimally to generate profits.
A Combined Differential Proteome and Transcriptome Profiling of Fast- and Slow-Twitch Skeletal Muscle in Pigs

Skeletal muscle fiber types can contribute in part to affecting pork quality parameters. Biceps femoris (Bf) (fast muscle or white muscle) and Soleus (Sol) (slow muscle or red muscle) are two typical skeletal muscles characterized by obvious muscle fiber type differences in pigs. However, the critical proteins and potential regulatory mechanisms regulating porcine skeletal muscle fibers have yet to be clearly defined. In this study, the isobaric Tag for Relative and Absolute Quantification (iTRAQ)-based proteome was used to identify the key proteins affecting the skeletal muscle fiber types with Bf and Sol, by integrating the previous transcriptome data, while function enrichment analysis and a protein–protein interaction (PPI) network were utilized to explore the potential regulatory mechanisms of skeletal muscle fibers. A total of 126 differentially abundant proteins (DAPs) between the Bf and Sol were identified, and 12 genes were found to be overlapping between differentially expressed genes (DEGs) and DAPs, which are the critical proteins regulating the formation of skeletal muscle fibers. Functional enrichment and PPI analysis showed that the DAPs were mainly involved in the skeletal-muscle-associated structural proteins, mitochondria and energy metabolism, tricarboxylic acid cycle, fatty acid metabolism, and kinase activity, suggesting that PPI networks including DAPs are the main regulatory network affecting muscle fiber formation. Overall, these data provide valuable information for understanding the molecular mechanism underlying the formation and conversion of muscle fiber types, and provide potential markers for the evaluation of meat quality.
Cytotoxic Assessment of 3,3-Dichloro-β-Lactams Prepared through Microwave-Assisted Benzylic C-H Activation from Benzyl-Tethered Trichloroacetamides Catalyzed by RuCl2(PPh3)3

Natural and synthetic β-lactam derivatives constitute an interesting class of compounds due to their diverse biological activity. Mostly used as antibiotics, they were also found to have antitubercular, anticancer and antidiabetic activities, among others. In this investigation, six new 3,3-dichloro-β-lactams prepared in a previous work were evaluated for their hemolytic and cytotoxic properties. The results showed that the proposed compounds have non-hemolytic properties and exhibited an interesting cytotoxic activity toward squamous cell carcinoma (A431 cell line), which was highly dependent on the structure and concentration of these β-lactams. Among the molecules tested, 2b was the most cytotoxic, with the lowest IC50 values (30–47 µg/mL) and a promising selectivity against the tumor cells compared with non-tumoral cells.
Impact of Manufacturing Stresses On Multiple-Rib Synchronous Reluctance Motor Performance

The effects of manufacturing stresses on the overall magnetic properties of electrical steel core applied in the stator and transversally-laminated rotor of Synchronous Reluctance motors are studied. In addition, it is investigated how the -manufacturing-degraded electrical steel core affects the electromagnetic performance of two different Synchronous Reluctance motors. The traditional transversally-laminated rotor of this kind of a machine requires the adoption of mechanical elements (inner and tangential ribs) to maintain its mechanical integrity. Especially, for high-speed applications, the number of rotor ribs must be increased to make the rotor withstand higher centrifugal forces. Lamination manufacturing typically affects the magnetic properties of electrical steel by reducing its permeability at the machined edge. This machining effect is greater when the overall core layer area surrounded by the machined edges is small i.e., the machined surface area ratio to the total core area is high. Considering this, the degradation of the core magnetic properties in the ribs could improve the performance of the machine, and this effect would be more visible when the machine is designed with a higher number of narrow ribs with the adoption of Topology Optimization. The paper aims to propose some guidelines for the simulation of these effects starting from the measurements on defined core samples and then based on the measured results the simulation model should be updated accordingly. The samples are manufactured from several assembled sheets in order to modify the width of the cut area while maintaining the same external geometry.
Exceptionally Lethal: American Police Killings in a Comparative Perspective

Police in the United States stand out in the developed world for their reliance on deadly force. Other nations in the Americas, however, feature higher or similar levels of fatal police violence (FPV). Cross-national comparative analyses can help identify stable and malleable factors that distinguish high-FPV from low-FPV countries. Two factors that clearly stand out among high-FPV nations are elevated rates of gun violence—which fosters a preoccupation with danger and wide latitude to use preemptive force—and ethnoracial inequality and discord. The latter seems to be tied to another fundamental difference between the United States and most other developed nations—the “radically decentralized structure of U.S. policing” (Bayley & Stenning 2016). Hyperlocalism limits the influence of external oversight, along with expertise and resources for effective training, policy implementation, and accountability. However, elevated rates of FPV among some Latin American countries with relatively centralized policing demonstrate that decentralization is not a necessary condition for high FPV. Likewise, relatively low FPV in Spain and Chile suggest that achieving low FPV is also possible without the extensive resources and training that appear to suppress FPV in wealthy Northern European nations. Expected final online publication date for the Annual Review of Criminology, Volume 6 is January 2023. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
SECOND ORDER SYMMETRIC DUALITY FOR NONDIFFERENTIABLE MULTIOBJECTIVE PROGRAMMING INVOLVING CONES

We construct Mond-Weir and Wolfe types of nondifferentiable multiobjective second order symmetric dual problems with cone constraints over arbitrary closed convex cones. Weak, strong, and converse duality theorems for weakly efficient solutions are established under the assumptions of second order invex and pseudo-invex functions. Several known results are obtained as special cases of our symmetric duality.
An exploration of multilevel effects of student- and school-factors on elementary students’ attitudes towards science

ABSTRACT By measuring students’ attitudes towards science using Rasch modelling, the present study investigated the factors related to elementary students’ attitudes toward science at both the individual- and school- levels using HLM in China, where students are often reported to have high achievement in science with below-average attitudes towards the subject. While little has been explored of the related field, it is a phenomenon worth noticing. By analysing a sample of over 6000 fifth graders from 66 schools, we found that most variance in student attitudes towards science occurred at the student level, but variations among schools were also significant. At the student level, gender, socioeconomic status, and teacher-student relationship were significantly associated to attitudes toward science. Male students, who have better socioeconomic status and perceive better teacher-student relationships, adopt more positive attitudes towards science. At the school level, the factors explored did not show significant correlation with students’ attitudes towards science. The findings are discussed, and implications for future research and science teaching have been provided.
Fabrication and performance analysis of high-performance cylindrical ionic polymer-metal composite actuators with various diameters

Ionic polymer-metal composites (IPMCs) are electroactive polymer actuators that have been used as artificial muscles and have broad application prospects. In order to further improve the actuation performance of cylindrical IPMCs, Nafion rods with different diameters were prepared by extrusion process, and cylindrical IPMCs with high-quality Pt electrode layers were prepared by electroless plating in this study. The electrochemical properties and actuation performance of cylindrical IPMCs with various diameters were investigated. The tests show that the prepared cylindrical IPMCs have excellent electromechanical properties. As diameter increases, the blocking force and counter back-relaxation ability both increase significantly. Furthermore, the IPMCs with diameter of 3.0 mm under a DC voltage exhibits a superior blocking force (323.9 mN) and excellent power density (up to 139.41 W m−3). Moreover, the thick cylindrical IPMC can lift objects 400 times its weight, demonstrating exceptional load capacity, which shows great prospect of realizing artificial muscles.
Three-dimensional vortex interactions in turbulent boundary layers

Abstract : A combined analytical experimental program, which has as its continuing objective the detailed investigation of the three dimensional vortex interactions which take place in turbulent boundary layers, is described and the accomplishments detailed. The analytical and numerical studies have examined both the development and characteristics of loop and hairpin vortices in both uniform and shear flows; particular attention has been paid to the strong three dimensional, inviscid viscous interaction of these types of vortical flow structures with wall region fluid. The experimental studies have focussed on the creation & detailed examination of three dimensional hairpin vortices, developing flow visualization patterns for cross-comparison with both the analytical studies and fully turbulent boundary layer flows. A technique for developing quantitative data by image processing of the visualization patterns is also described. Keywords: Turbulent boundary layer; Coherent structure; Flow visualization; Numerical modelling; Vortex wall interactions; Computer aided analysis; Loop vortices; Hairpin vortices.
New Population Synthesis Models of the Cosmic UV Background

We present improved synthesis models of the evolving spectrum of the UV/X-ray diffuse background, updating and extending our previous results. A "minimal cosmic reionization model" is presented in which the galaxy UV emissivity traces recent determinations of the cosmic history of star formation, the luminosity-weighted escape fraction of hydrogen-ionizing radiation increases rapidly with redshift, from 1% at z=3 to 50% at z=8.5, the clumping factor of the intergalactic medium is C=3, and Population III stars make a negligible contribution to the metagalactic flux. The model provides a good fit to the hydrogen-ionization rates inferred from flux decrement measurements, and yields an optical depth to Thomson scattering, tau_e=0.085, that is in agreement with WMAP results.
Improving Students' Learning Outcomes in Public Vocational High School by Implementing Problem-Based Learning with Scientific Approach

This study explored the effect of combining a scientific approach with problem-based learning on enhancing students' critical thinking skills. The scientific approach sought to direct learners to understand various materials scientifically from multiple sources. The quantitative study in the experimental design used the nonrandomized control group treated with pre-test post-test design. This study had 48 students who separated into two groups. The experimental group used a problem-based learning and scientific approach (PBL-SA), whereas the control group used a traditional learning approach. According to the findings, the average post-test score for the traditional learning group was 33.33, whereas the average post-test score for the PBL-SA group was 65.42. The traditional learning group had low scores, whereas the average achievement of students in the PBL-SA group increased from 42.08 to 65.42, indicating an improvement. The PBL-SA group outperformed the traditional learning group on the Basic Mechanical Engineering Design with a statistically significant difference.
EMPLOYEE PERFORMANCE REVIEW OF COMPETENCE, MOTIVATION, AND WORK DISCIPLINE AT PT INDAH LOGISTIC SOLO BRANCH

Developments in the fast-paced economy and superior human resources are a separate value for a company. Companies must be able to improve and make plans and evaluate each other's performance so that the company develops and has the value of public trust through its resources. This study aims to determine the effect of competence, motivation, and work discipline on employee performance at PT. Indah Logistics Solo Branch. The research approach used is descriptive quantitative. Non-probability sampling was used in this study with a saturated sample method of 58 irespondents. iThe ianalysis iis imultiple linear regression. The iresult is that competence has a positive and significant effect on employee iperformance iwith ia it-value = 1.676 > it-table value = 1.674. Motivation has a ipositive iand isignificant ieffect ion iemployee performance with ia value of t icount = 1.789 > it itable = 1.674 iand discipline has ia positive and significant effect on employee performance with a value of t count = 4.455 > it itable = 1.674. Keywords: Employee performance, competence, motivation, work discipline
Management of Patients at Risk for and With Left Ventricular Thrombus: A Scientific Statement From the American Heart Association

Despite the many advances in cardiovascular medicine, decisions concerning the diagnosis, prevention, and treatment of left ventricular (LV) thrombus often remain challenging. There are only limited organizational guideline recommendations with regard to LV thrombus. Furthermore, management issues in current practice are increasingly complex, including concerns about adding oral anticoagulant therapy to dual antiplatelet therapy, the availability of direct oral anticoagulants as a potential alternative option to traditional vitamin K antagonists, and the use of diagnostic modalities such as cardiac magnetic resonance imaging, which has greater sensitivity for LV thrombus detection than echocardiography. Therefore, this American Heart Association scientific statement was commissioned with the goals of addressing 8 key clinical management questions related to LV thrombus, including the prevention and treatment after myocardial infarction, prevention and treatment in dilated cardiomyopathy, management of mural (laminated) thrombus, imaging of LV thrombus, direct oral anticoagulants as an alternative to warfarin, treatments other than oral anticoagulants for LV thrombus (eg, dual antiplatelet therapy, fibrinolysis, surgical excision), and the approach to persistent LV thrombus despite anticoagulation therapy. Practical management suggestions in the form of text, tables, and flow diagrams based on careful and critical review of actual study data as formulated by this multidisciplinary writing committee are given.
Assessment of COVID-19 Symptoms Distribution According to Tobacco Products Consumption and Khat Chewing: A Potential Antinociceptive Role of Nicotine Among COVID-19 Patients

Purpose To assess the distribution of COVID-19 symptoms according to the consumption of tobacco products and khat chewing among samples of Saudi Arabian individuals. Methods This retrospective cohort study was conducted in the Jazan region of Saudi Arabia. Data was collected online via a self-administered questionnaire. The questionnaire measured demographic variables, COVID-19 symptoms and vaccination, comorbidities history, tobacco product consumption, and khat chewing. In addition, logistic regression was performed to assess the association between the clinical presentation of COVID-19 with tobacco product consumption and khat chewing. Results A total of 1026 subjects were recruited. The mean age of the participants was 31 years, and more than half were male (53%). Among the reported tobacco product consumption, hookah smoking was more frequently reported as a currently consumed tobacco product (14.3%), followed by cigarette smoking (11.5%) and chewing tobacco (3.8%). Thirteen percent (134) were khat chewers at the time of recruitment. The odds of reporting five symptoms or more were higher among patients who have never been tobacco product consumers (OR: 1.6, 95% CI: 1.15–2.35) while accounting for khat chewing, age, vaccination status, and history of comorbidities. Nonetheless, the difference in symptom distribution with khat chewing status was not statistically significant. Conclusion The findings of the current investigation suggest the presence of a potential impact of nicotine toxicity in masking pain among the subjects infected with COVID-19. Therefore, it is possible to hypothesize that, with the potential masking effect of nicotine, infected smokers may be less likely to suffer from the symptoms and seek official healthcare services, including diagnostic services.
Availability of Urea, Ammonium, and Nitrate Applied to Pine Bark

Initial availability of NO3, NH4, and urea applied to limed or unlimed pine bark as well as the form of N available over a period of 21 days was determined. Nitrate was not present in significant amounts when N was supplied as either urea or NH4, and the extractable amounts of both urea and NH4 declined significantly over the course of the experiment. Urea was the least effective of the N forms in supplying N in an extractable form. With NO3 as the N source, addition of lime to pine bark resulted in significant reductions in extractable NO3. Applications of NH4 gave relatively equal amounts of extractable N as NH4 from limed and unlimed pine bark after 21 days. It was concluded that N interaction and N transformations with these N forms in pine bark would influence total available N as well as the form of N available for plant growth.