Miracle-dz/UniFAR-FTUs huggingface dataset:
Machine Learning Methods to Analyze and Predict Crash Injury Severity Based on Contributing Factors for Southeast Michigan

Traffic safety is a critical aspect of transportation. Transportation agencies and researchers have been continuously making an effort to ensure minimal error margins in the road system. There is a growing interest in the Southeast Michigan region because of the active role of original equipment manufacturers in spurring research in the new mobility field and autonomous vehicle technology. As new jobs are created and commuting trips increase, traffic safety becomes even more important. Thus, this study presents one of the first efforts to study crash patterns for Southeast Michigan using machine learning models to analyze and predict crash severity in the region based on various contributing factors. We combine a three-step method of correlation analysis, machine learning predictive models, and spatial analysis to develop a rigid schema for crash prediction. Results show that decision tree classifiers provide accurate predictions and rapid computations. Also, spatial plots of predicted injury severities reveal disproportionate errors in model predictions at intersections prompting the need to stratify the crash data for further analyses. This significantly improves severe injury predictions at non-intersection locations and highlights pedestrians as a main important feature. The converse holds for intersections that identify motorcycles as the main feature for severity prediction. Further results are elucidated in this paper.
A Comprehensive Study on the Effect of Regular and Staggered Openings on the Seismic Performance of Shear Walls

Shear walls have high strength and stiffness, which could be used at the same time to resist large horizontal loads and weight loads, making them pretty beneficial in several structural engineering applications. The shear walls could be included with openings, such as doors and windows, for relevant functional requirements. In the current study, a building of G + 13 stories with RC shear walls with and without openings has been investigated using ETABS Software. The seismic analysis is carried out for the determination of parameters like shear forces, drift, base shear, and story displacement for numerous models. The regular and staggered openings of the shear wall have been considered variables in the models. The dynamic analysis is carried out with the help of ETABS software. It has been observed that shear walls without openings models perform better than other models, and this is in agreement with the previous studies published in this area. This investigation also shows that the seismic behaviour of the shear wall with regular openings provides a close result to the shear wall with staggered openings. At the roof, the displacement of the model with regular openings was 38.99 mm and approximately 39.163 mm for the model with staggered openings. However, the model without a shear wall experienced a displacement of about 56 mm at the roof. Generally, it can be concluded that the openings have a substantial effect on the seismic behaviour of the shear wall, and that should be taken into consideration during the construction design. However, the type of opening (regular or staggered) has a slight effect on the behaviour of shear walls.
Exploring the Underlying Mechanism of Ren-Shen-Bai-Du Powder for Treating Inflammatory Bowel Disease Based on Network Pharmacology and Molecular Docking

Ren-Shen-Bai-Du Powder (RSBDP) is currently used for inflammatory bowel disease (IBD) therapy in China. However, its potential mechanism against IBD remains unknown. In this study, we initially identified potential targets of RSBDP against IBD through network pharmacology analysis and molecular docking. Afterwards, the DSS-induced colitis mice model was employed to assess the effects of RSBDP. The results of network pharmacology indicated that a total of 39 main active ingredients in RSBDP generated 309 pairs of drug-ingredient and ingredient-target correspondences through 115 highly relevant targets of IBD. The primary ingredients (quercetin, kaempferol, luteolin, naringenin, and sitosterol) exerted functions through multiple targets that include CYP1B1, CA4/7, and ESR1/2, etc. GO functional enrichment analysis revealed that the targets related to IBD were significantly enriched in the oxidation-reduction process, protein binding, and cytosol. Per the KEGG pathway analysis, pathways in cancer, adherens junction, and nitrogen metabolism were pivotal in the RSBDP’s treatment of IBD. Additionally, molecular docking demonstrated that a set of active ingredients and their targets displayed good bonding capabilities (e.g., kaempferol and AhR with combined energy < 5 kcal/mol). For the animal experiment, oral RSBDP promoted weight recovery, reduced intestinal inflammation, and decreased serum IL-1, IL-6, and IL-8 concentrations in the DSS + RSBDP group. Meanwhile, oral RSBDP significantly up-regulated the mRNA levels of CA7, CPY1B1, and PTPN11; in particular, the expression level of CYP1B1 in the DSS + RSBDP group was up-regulated by as high as 9-fold compared to the DSS group. Western blot results indicated that the protein levels of AKR1C1, PI3K, AKT, p-AKT, and Bcl-2 were significantly down-regulated, and Bax was significantly up-regulated in the DSS + RSBDP group. Compared to the DSS and control groups, the Bax/Bcl-2 value in the DSS + RSBDP group increased 4-fold and 8-fold, respectively, which suggested that oral RSBDP promotes apoptosis of intestinal epithelial cells. In short, this study established quercetin, kaempferol, luteolin, naringenin, and sitosterol as the primary key active ingredients of RSBDP that exert synergistic therapeutic effects against IBD through modulating the AhR/CYP1B1 and AKR1C1/PI3K/AKT pathways.
Accumulated Vitrified Embryos Could Be a Method for Increasing Pregnancy Rates in Patients with Poor Ovarian Response

We aimed to assess the efficacy of accumulated embryo transfer (ACC-ET) through several controlled ovarian hyperstimulation (COS) cycles to increase the rates of pregnancy in patients with poor ovarian response (POR). We retrospectively reviewed the medical records of 588 patients with POR under 43-years old who underwent embryo transfer from January 2010 to December 2015. We compared the pregnancy rate (PR), clinical pregnancy rate (CPR), and live birth rate (LBR) between ACC-ET (frozen-thawed: 47; fresh + frozen-thawed: 24) group (n = 71) and fresh ET groups (n = 517). Characteristics of ACC-ET patients were similar to those of fresh ET groups (Age: 38.1 ± 3.5 vs. 38.2 ± 3.7, p = 0.88; Anti Müllerian Hormone (AMH; ng/mL): 0.5 ± 0.4 vs. 0.6 ± 0.6, p = 0.38; follicle stimulating hormone (FSH: mIU/mL): 11.9 ± 8.0 vs. 10.8 ± 9.0, p = 0.35). The total number of transferred embryos (3.1 ± 0.9 vs. 1.5 ± 0.7, p = 0.00), PR (29.6% (21/71) vs. 18.8% (97/517), p = 0.040), and CPR (23.5% (16/68) vs. 14.0% (71/508) p = 0.047) were significantly higher in the ACC-ET group than in the fresh ET group. In addition, PR, CPR, and LBR increased with the number of ET in the fresh ET group. However, there were no significant differences observed in LBR between ACC-ET and fresh ET groups (14.9% (10/67) vs. 9.8% (50/508), p = 0.203). From our knowledge, there is no clinical evidence reported to prove that transfer of multiple embryos of adequate quality obtained through multiple cycles can compensate for the limited number of retrieved oocytes from POR patients. We concluded that ACC-ET from several COS cycles could be an alternative method to increase PR and CPR in <43-year-old patients with POR.
Parametric Pushover Analysis on Elevated RC Pile-Cap Foundations for Bridges in Cohesionless Soils

For bridges under seismic excitations, current design practices recommend to comply with the capacity protection principle for pile foundations. However, in cases, such as elevated (or scoured) RC pile-cap foundation typologies that are partially embedded, the piles may suffer large deflections under lateral loads, which make it difficult for them to remain in the elastic state. In this regard, the present study makes an in-depth analysis on the ductile behavior of elevated RC pile-cap foundations to explore potentials for seismic ductile design. A beam-on-nonlinear-Winkler-foundation model with or without the consideration of bond-slip effect at pile head/cap connections is built in accordance with quasi-static testing of a 2 3 elevated RC pile-cap foundation, and validated in various aspects, including the global forcedisplacement relationship, the failure mechanism, and the location of plastic hinges. The validation results indicate that the bond-slip effect is generally unremarkable and can be neglected for the modeling of studied elevated pile-cap foundations (EPFs). Two limit states and the corresponding ductility factors, named easy-to-repair and ultimate displacement ductility factors, are proposed for EPFs. Parametric pushover analyses are then performed to investigate the impact of structural and geotechnical parameters on the ductile behavior of real-scale 2 3 elevated RC pile-cap foundations embedded in homogeneous and multilayered cohesionless soils. The numerical results show considerable ductile capacities (with an average quantified as 2.77 and 4.05 for the easy-to-repair and ultimate displacement ductility factors, respectively) for elevated RC pile-cap foundations. Additionally, a mathematical relationship between displacement and curvature ductility factors is established for future ductility-based design practices.DOI: 10.1061/(ASCE)BE.1943-5592.0001328. © 2018 American Society of Civil Engineers. Author keywords: Elevated RC pile-cap foundation; Parametric analysis; Pushover; Ductility; Scour; FEM.
Co-Microencapsulation of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits and Lactic Acid Bacteria into Antioxidant and Anti-Proliferative Derivative Powders

Driven by the modern lifestyle, the consumers are interested in healthier and balanced diets, including both probiotics and natural antioxidants. The beneficial health effects of probiotics are mainly due to their capacity of modulating the human intestinal microbiota, although achieving at least a 6 log of viable cells at the targeted site is still challenging. Therefore, in this study, an attempt to improve the bioaccessibility of Lacticaseibacillus casei (L. casei) 431® through a co-microencapsulation by complex coacervation and freeze-drying, using an extract from Cornelian cherry and two biopolymeric matrices, whey protein isolates and casein (WPI-CN) and inulin (WPI-I), was studied. The powders showed a comparable anthocyanin content of around 32.00 mg cyanidin-3-rutinoside (C3R)/g dry matter (DM) and a microbial load of about 10 Log CFU/g DM. A high stability of the lactic acid bacteria was assessed throughout 90 days of storage, whereas the anthocyanins’ degradation during storage followed a first order kinetic model, allowing the estimation of a half-time of 66.88 ± 1.67 days for WPI-CN and 83.60 ± 2.46 days for WPI-I. The in vitro digestion showed a high stability of anthocyanins in the simulated gastric juice, whereas the release in the simulated intestinal juice was favored in the variant with inulin (up to 38%). The use of casein permitted to obtain finer spherosomes, with smaller diameters, whereas a double encapsulation was obvious in both variants, thus explaining the high resistance in the gastric environment. The anti-proliferative effect against the human colon cancer cell line (HT-29) was also demonstrated. No cytotoxicity has been found for the concentrations between 1 and 25 μg/mL for the WPI-I variant, whereas a cell proliferation effect was observed at low concentrations of 1–5 μg/mL.
Reassessing contemporary labour curves

OBJECTIVES: Our purpose was to analyse the pattern of labor progression in Low risk parturients in contemporary obstetric practice. STUDY DESIGN: We extracted detailed labor data from 1531 low risk parturients with a term, singleton, vertex fetus of normal birth weight after spontaneous onset of labor. Cesarean deliveries,instrumental deliveries and those needed oxytocin augmentation were excluded.Those women whose new born needed resuscitation were also excluded. We used statistical measures to discover the average labor curve under contemporary practice. We also computed the expected time interval of the cervix to reach the next centimeter, the expected rate of cervical dilation at each phase of labor. RESULTS: Our average labor curve differs markedly from the Friedman curve . The cervix dilated substantially slower till 6 cm cervical dilatation. It took approximately 3.66 hours from 4 cm to 10 cm, compared with 2.5 hours under the Friedman curve. We observed no deceleration phase . Mean rate of cervical dilatation in active phase of labour was 1.42 cm/hr which is less than friedman’s rate of cervical dilatation which was 3 cm/hr. As per Zhang et al labour progress differentially at different degree of dilatation.
Evaluation of Skin Cancers in a 7-year Plastic Surgery Archive (2014-2020)

most common type of in the United States of (USA). In the etiology of MM; UVB, genetic and environmental factors play a role. and neck region (most frequently in the nose region). All our patients were treated with appropriate surgical treatments (wide excision primary surgical repair, surgical repairs with flaps and grafts) and the patients were followed up for at least 1 year. Recurrence was observed in 71 of 852 patients after surgical excision and they were re-excised. Conclusion: In our study; we have found that our region in general had a similar incidence of malignant skin tumors compared with the other studies. The localization, surgical treatment and follow-up results were also similar. This study will shed light on the characteristics, behaviors, preventive measures, diagnosis and treatment of skin cancers. ABSTRACT
Nomogram Prediction Model of Serum Chloride and Sodium Ions on the Risk of Acute Kidney Injury in Critically Ill Patients

Purpose This study aims to investigate the effect of serum chloride and sodium ions on AKI occurrence in ICU patients, and further constructs a prediction model containing these factors to explore the predictive value of these ions in AKI. Methods The clinical information of patients admitted to ICU of Beijing Friendship Hospital Affiliated to Capital Medical University was collected for retrospective analysis. Logistic regression analysis was used to analyzing the influencing factors. A nomogram for predicting AKI risk was constructed with R software and validated by repeated sampling. Afterwards, the effectiveness and accuracy of the model were tested and evaluated. Results A total of 446 cases met the requirements of this study, of which 178 developed AKI during their stay in ICU, with an incidence rate of 39.9%. Hypernatremia, heart failure, sepsis, APACHE II score, and initial creatinine value and BE value at ICU admission before the diagnosis of AKI were identified as independent risk factors for developing AKI during ICU stay. These predictors were incorporated into the nomogram of AKI risk in critically ill patients, which was constructed by using R software. Receiver operating characteristic curve analysis was further used and showed that the area under the curve of the model was 0.7934 (95% CI 0.742–0.8447), indicating that the model had an ideal value. Finally, further evaluated its clinical effectiveness. The clinical effect curve and decision curve showed that most areas of the decision curve of this model were greater than 0, indicating that this model owned a certain clinical effectiveness. Conclusion The nomogram based on hypernatremia, heart failure, sepsis, APACHE II score, and initial creatinine and BE value in ICU can predict the individualized risk of AKI with satisfactory distinguishability and accuracy.
Relationships of the very low birth weight infant microbiome with neurodevelopment at 2 and 4 years of age.

Very low birth weight (VLBW) infants (<1500 g) are at risk for poor neurodevelopmental outcomes depending on gestational age (GA), birth weight (BW), and morbidity in early life. The contribution of the gut microbiome is not well understood. Stool samples were collected weekly in the neonatal intensive care unit (NICU) from 24 VLBW infants for 6 weeks after admission and then again at 2 and 4 years of age. The Battelle Development Inventory-2 Screening Test (BDI-2 ST) was administered at 2- and 4-year time points. VLBW infants had dysbiotic microbiota in the NICU that progressed for most to an adult-type microbiota by 4 years of age. The BDI-2 ST results at age of 2 years triggered referral for further testing in 14 toddlers (70%), and by 4 years of age only seven of these 14 continued to require referral. Both NICU infant stool diversity and particular microbial amplicon sequence variants were associated with BDI-2 ST subscales, particularly for cognition, adaptive, and communication subscales, when controlled for GA, BW, and antibiotic exposure. Network analysis of the NICU infant stool microbial ecology showed differences in children needing neurodevelopmental referral. The results of this preliminary study indicate that the neonatal gut microbiome plays a role in early cognitive and behavioral neurodevelopment.
Video Analysis of Pectoralis Major Injuries in Professional Australian Football Players

Background: There is little evidence regarding the mechanisms of pectoralis major (PM) injury and player outcomes in Australian Football League (AFL) players. Purposes/Hypothesis: The study aims were to investigate (1) the mechanisms of PM muscle injury in elite AFL players via video analysis and (2) the player profile, method of management, and clinical outcomes of the PM injuries sustained. We hypothesized that the majority of PM tears would occur in outer-range PM positions (hyperextension of the glenohumeral joint). Study Design: Case series; Level of evidence, 4. Methods: We analyzed video of the precipitating event for traumatic PM injuries during AFL competition or training over a 20-year period (2002-2021). The footage was analyzed by 4 experienced assessors, and the following were evaluated: mechanism of injury, injury variables (arm position, initial contact point, visual awareness, and use of taping), player characteristics (age at the time of injury, hand dominance, and history of injury), injury profile (location and size of tear), method of management (operative vs nonoperative), patient outcomes (time to return to full senior training/match play), and complication rates. Results: The mean ± standard deviation age of the players was 26.5 ± 3.1 years (range, 21-32 years). Overall, 22 PM injuries were identified in the AFL injury database for a rate of 1.1 per year; 16 of these injuries had accompanying video footage. We identified 3 mechanisms for PM injury: horizontal hyperextension (62.5%), hyperflexion-abduction (25.0%), and horizontal adduction (sustained tackling; 12.5%). The most common site of the tear was the insertion point of the sternocostal head (91.0%). Twenty players (91.0%) required surgical repair, with 75% undergoing surgery within 1 week (range, 0-26 weeks). The mean return to competition for the surgical repair group was 11.1 weeks (range, 8-15 weeks). The rerupture rate was 5.0% (1 repair; <4 weeks postoperatively in 2004). Conclusion: PM tears in elite male AFL players were due to 1 of 3 distinct mechanisms: horizontal hyperextension, hyperflexion-abduction, and horizontal adduction (sustained tackling). Players returned to play on average 11 weeks after injury. Knowledge regarding mechanisms of injury, player profile, and return-to-sport timelines is important for appropriate medical management and provides potential areas to target for prevention of PM injuries.
Informal Caregivers’ Perceptions of Self-Efficacy and Subjective Well-Being When Using Telecare in the Home Environment: A Qualitative Study

Background: Self-efficacy (SE) can be used to explain informal caregivers’ ability to cope with the challenges of caregiving. Although SE impacts informal caregivers’ subjective well-being, its effects have not yet been studied from the perspective of telecare use. This study aimed to explore informal caregivers’ perceptions of and associations between SE and subjective well-being when using different telecare functionalities. Methods: A four-month intervention study using a qualitative research design was conducted. In-depth interviews were conducted with 22 informal caregivers of older people who tested one of two telecare devices in their homes. Results: Five task-specific dimensions of caregiver SE were identified that were shaped by telecare use: controlling upsetting thoughts about the care recipient, managing protective vigilance, obtaining support in emergency situations, managing caregiving, work, family life, and responding in a timely manner to changes in the care recipient’s daily routine. These SE dimensions were associated with caregivers’ subjective well-being. Conclusions: Telecare use may contribute to greater caregiver SE and higher subjective well-being. Therefore, future studies should pay more attention to these potential benefits of telecare. Additional dimensions of caregiver SE should be included in existing caregiver SE scales when examining caregiver SE related to telecare use.
Occidiofungin: Actin Binding as a Novel Mechanism of Action in an Antifungal Agent

The identification and development of natural products into novel antimicrobial agents is crucial to combat the rise of multidrug-resistant microorganisms. Clinical fungal isolates have been identified, which have shown resistance to all current clinical antifungals, highlighting a significant need to develop a novel antifungal agent. One of the natural products produced by the bacterium Burkholderia contaminans MS14 is the glycolipopeptide occidiofungin. Occidiofungin has demonstrated in vitro activity against a multitude of fungal species, including multidrug-resistant Candida auris strains, and in vivo effectiveness in treating vulvovaginal candidiasis. Characterization of occidiofungin revealed the mechanism of action as binding to actin to disrupt higher-order actin-mediated functions leading to the induction of apoptosis in fungal cells. Occidiofungin is the first small molecule capable of disrupting higher-order actin functions and is a first-in-class compound that is able to circumvent current antifungal resistant mechanisms by fungal species. Anticancer properties and antiparasitic activities, against Cryptosporidium parvum, have also been demonstrated in vitro. The novel mechanism of action and wide spectrum of activity highlights the potential of occidiofungin to be developed for clinical use.