Miracle-dz/UniFAR-FTUs huggingface dataset:
The risk of developing psoriasis in alcohol-dependent patients and possible therapeutic strategies

Excessive alcohol consumption significantly contributes to the damage of the nervous, cardiovascular and digestive systems. According to the latest scientific reports, excessive ethanol consumption might also contribute to an increased risk of developing skin diseases such as rosacea, porphyria cutanea tarda or psoriasis. The risk of developing psoriasis in alcohol-dependent patients is estimated at 3.1-3.4%. Among these people, in addition to the use of traditional therapeutic strategies, therapy with drugs acting on the neurotransmitter systems may constitute a potential treatment. Chronic alcohol consumption increases the activation of T lymphocytes as well as the level of tumor necrosis factor-α (TNF-α) and also stimulates the excessive proliferation of keratinocytes. These factors dysregulate the immune system, predisposing to the risk of developing psoriasis. Alcohol also interferes with signaling through neurotransmission affecting dopaminergic and serotonergic systems, which may affect the immune processes in the pathogenesis of psoriasis. The results of the research showed that the daily consumption of alcohol in an amount greater than 80 grams significantly reduces the effectiveness of treatment in psoriatic patients. Moreover, traditional drugs used in the course of psoriasis (retinoids, methotrexate, cyclosporine) may show reduced activity or even lead to toxic side effects (liver fibrosis) if alcohol is not discontinued during therapy. Treatment of psoriatic patients and coexisting alcohol dependence is a separate therapeutic problem. In addition to traditional methods, drugs that affect the neurotransmitter system may become a chance, mainly due to the influence of alcohol on these systems and modulation of the immune response, which is important in the development of psoriasis.
Single-Center Comparison of Laparoscopic Incisional Ventral Hernia Repair using Different Meshes

Results: The baseline characteristics of the three groups were similar. Recurrent ventral hernias were more frequent in the Dual MeshTM group (23.4 vs. 0 vs 0%; P=0.01). Perioperative complications and quality of life scores after surgery were also similar. Postoperative hematomas occurred in 3 (17.6%) patients in the ParietexTM group, in 1 (2.1%) patient in the Dual MeshTM group and in none of the patients in the Physio meshTM group (P=0.02). The incidence of recurrence was comparable, although the median follow-up was longer in the Physio meshTM group (57 months), P=0.001.
Synthesis of Conjugated Polymer Based in Zn(II) Porphyrin Bearing Terminal Alkynyl Groups as Photosensitizer

5,10,15,20-tetrakis-[4-(ethynyl)phenyl]porphyrin (TEP) was synthesized from the condensation of 4-(ethynyl)benzaldehyde and pyrrole catalyzed by boron trifluoride diethyl etherate in dichloromethane (DCM). After oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and purification, TEP was obtained in 34% yield. This porphyrin was metaled with Zn(II) acetate in DCM/methanol to produce the complex ZnTEP in 98% yield. A homocoupling reaction of terminal alkynes of ZnTEP to diynes was used to synthesize conjugated polymer organogel (ZnTEPP). The reaction was co-catalyzed by PdCl2(PPh3)2 and CuI in tetrahydrofuran. The solvent was evaporated to obtain xerogel and the SEM images showed microporous structure. In addition, spectroscopic and photodynamic studies of ZnTEPP indicated that the porphyrin unit retains its properties as a photosensitizer. Thus, this polymer is an interesting material with potential applications in forming photoactive aseptic surfaces.
Mediation Role of Social Support and Burnout Between Financial Satisfaction and Turnover Intention in Primary Care Providers: A Cross-Sectional Study

Background: Turnover intention is a major cause of reduced team morale and low work efficiency. It hinders work performance and reduces the quality of medical services. This study aimed to investigate the relationship between financial satisfaction and turnover intention and its mediators among primary care providers.Methods: Stratified sampling was used to select 1241 participants from three counties in Anhui province, China. Data were collected using self-administered questionnaire. Turnover intention was assessed with a turnover intention assessment scale. Social support and burnout were measured with the 12-item Perceived Social Support Scale and the Chinese version of the Maslach Burnout Inventory, respectively. Structural equation modeling was used for data analysis.Results: The findings showed high turnover intention among primary care providers (mean score 14.16±4.337), and most providers reported low financial satisfaction (mean score 2.49±0.990). The mean social support score was 64.93±13.229, and only 6.1% of primary care providers reported no burnout. Compared with participants with high financial satisfaction, those with low financial satisfaction were more likely to report higher turnover intention (β=−0.216, p<0.001), more social support (β=0.181, p<0.001), and more severe burnout (β=−0.123, p<0.05). Turnover intention may be related to social support (β=−0.147, p<0.001) and burnout (β=0.239, p<0.001). Furthermore, the effect of financial satisfaction on turnover intention was significantly mediated by social support (β=−0.027, p<0.001) and burnout (β=−0.029, p<0.05). Conclusions: Turnover intention is associated with financial satisfaction, with this association mediated by social support and burnout. A reasonable mechanism needs to be established to improve the financial satisfaction and social support and reduce burnout among primary care providers.
Social axioms and coping strategies: the case of a Greek sample

Explaining human behavior is critical in understanding cultural differences. Various psychological constructs have been employed in order to give better insight on culture and cultural differences of human behavior. Research studies based on this view and focused on unpackaging culture, at the individual level, offered mixed empirical results so far, based either on value priorities or on personality traits and general attitudes (Bond et al., 2004; Chen, Bond, & æYXO§O°IA, 2009, 16 (2) ◆ 164-174 PSYCHOLOGY, 2009, 16 (2) ◆ 164-174
Visualizations of Topologic Entropy on SARS-CoV-2 Genomes in Multiple Regions

The outbreak of novel coronavirus (SARS-CoV-2) developed into a global pandemic in a few months. The latest study found that the virus belongs to the beta coronavirus family. SARS-CoV-2 is highly similar to Pangolin CoV and BatCoV RaTG. Advanced scientific studies help traceability and vaccine development. In addition to the subgenus classification analysis of the virus, it is interesting for further exploration to focus attention on mutations and their transmissions in different regions. New mutations may be likely to affect the symptoms of the disease and the effectiveness of vaccination. This paper is focused on the study to make error bars and scatter graphs with the support of the metagenetic analysis system MAS. Using SARS-CoV-2 genomes in different countries and regions as input datasets, topological entropy values provide global characteristic quantities based on C4 module for visualization. Sample results show that the method is powerful and useful for consistently integrating all genomes on one unique genomic index map. Various countries have confirmed their specific positions and projections under topologic entropies. Further explorations are required.
Enhance Image Classification Performance Via Unsupervised Pre-trained Transformers Language Models

Image classification and categorization are essential to the capability of telling the difference between images for a machine. As Bidirectional Encoder Representations from Transformers became popular in many tasks of natural language processing recent years, it is intuitive to use these pre-trained language models for enhancing the computer vision tasks, \eg image classification. In this paper, by encoding image pixels using pre-trained transformers, then connect to a fully connected layer, the classification model outperforms the Wide ResNet model and the linear-probe iGPT-L model, and achieved accuracy of 99.60%～99.74% on the CIFAR-10 image set and accuracy of 99.10%～99.76% on the CIFAR-100 image set.
Health status of blood cockle's Tegillarca granosa (Arcidae: Bivalva) from three different farms along the Strait of Malacca

The annual production of Tegillarca granosa in Perak and Selangor is constantly decreasing since 1996, however a different production pattern was reported in Johor where it was fluctuated for the past years. Thus, this study was done to provide information on the health condition of T. granosa through morphological observation of the biological attributes and the anatomy of the gill’s tissue. Sampling work was done in dry seasons between May and July 2019 at Bagan Pasir Laut, Perak, Kuala Sungai Buloh, Selangor and Sungai Ayam, Johor. A group of 22-30 T. granosa were collected randomly from each site for biological attribute measurement and the mean were analyzed using Kruskal-Wallis. Six to seven cockles with shell length ranging 25.00 – 35.00 mm were selected for the gill’s histological observation. Fresh T. granosa samples were preserved in 10% formalin before dissection and then the gills were fixed in Bouin's solution, followed by histological standard procedures and haematoxylin and eosin staining. Results indicated a significant difference of biological attributes was detected between the sites with the lowest measurement found in samples from Bagan Pasir Laut. The highest body weight (14.08g) was found in samples from Kuala Sungai Buloh, followed by Sungai Ayam (10.81g) and then Bagan Pasir Laut (8.08g). The histology of the gill filaments of samples from Sungai Ayam are full of hemocytes, well-structured epithelium cells with cilia in comparison to samples from Bagan Pasir Laut, and Kuala Sungai Buloh. The most degenerated gill filaments were found in samples from Bagan Pasir Laut. Thus, suggesting the unhealthy condition of the gills, affects the shell sizes and body weight of T. granosa between the three established farms.
Ultrathin Polyamide Membranes Fabricated from Free-Standing Interfacial Polymerization: Synthesis, Modifications, and Post-treatment

The thin film composite (TFC) membrane synthesized via interfacial polymerization is the workhorse of the prevalent membrane technologies such as nanofiltration (NF), reverse osmosis (RO), forward osmosis (FO), and pressure retarded osmosis (PRO) membranes. The polyamide selective layer usually possesses a high selectivity and permeability, making it the heart of this membrane technology. To further improve and understand its formation, with entirely excluding the effect of substrate, an ultrathin membrane which consists of only the polyamide selective layer has been fabricated via free-standing interfacial polymerization between M-phenylenediamine (MPD) and trimesoyl chloride (TMC) in this study. The influences of monomer concentration on polyamide layer formation is first examined. Different from previous studies which indicated that the variation of MPD concentration might affect the polyamide layer formation even when in excess, the MPD concentration when in excess does not affect membrane properties .
Pacific Biosciences Single-molecule Real-time (SMRT) Sequencing Reveals High Diversity of Basal Fungal Lineages and Stochastic Processes Controlled Fungal Community Assembly in Mangrove Sediments

Background: Mangrove wetlands are unique ecosystems with specific environmental characteristics, and are a hotspot of biodiversity. Although they probably harbor a variety of mangrove-specific fungi, the compositions of mangrove fungal community has been rarely investigated in detail, except for few published culture-based studies. In addition, the fungal community assembly and interaction patterns that impact the community composition in mangroves have not been explored to date. Results: We used the Pacific Biosciences single-molecule real-time sequencing approach targeting the entire internal transcribed spacer region, to systematically investigate the composition, biogeographical patterns, assembly processes, co-occurrence patterns and shaping factors of the fungal communities in sediments of seven representative mangroves across the Southeast China. We recovered 15 phyla, including some early diverging fungal lineages not previously reported in mangroves. Phylogenetic analysis revealed an incredibly high proportion of Rozellomycota and Chytridiomycota, as accounting for up to one-third of all fungal abundance. Although the neutral community model described a moderate portion of community variation, the similarity of fungal communities exhibited strong distance-decay patterns. Furthermore, the mean values and most beta nearest-taxon index fell between -2 to 2, with Bray–Curtis-based Raup–Crick value generally greater than 0.95, suggesting that stochastic processes strongly shape the fungal community composition. Consistently, nonmetric multidimensional scaling and permutational multivariate analysis of variance confirmed the geographical location as a crucial factor driving the distribution of both, the dominant and rare taxa of mangrove fungi. The db-RDA analyses indicated a minor role of environmental selections in shaping the fungal community. Network analyses revealed that the deep sediments harbor more complex fungal networks with highly connected taxa than surface sediments, and that rare fungal taxa might play important roles in microbial interactions and ecological functions in mangrove sediments.Conclusions: The investigation revealed high fungal diversity in mangrove sediments, with incredibly high numbers of basal fungal lineages, stochastic processes driving the assembly of fungal community, and geographic location strongly shaping fungal community composition in mangroves. These discoveries therefore spur further studies of the utilization and protection of fungal resources and communities in mangrove sediments.
Expected Bond Liquidity

We introduce an approach to forecast individual bond liquidity and apply it to the U.S. corporate bond market. Our model combines three dynamic prediction models to get the most accurate estimate for future bond liquidity. We compare the new prediction methodology with the literature’s current approach to use a bond’s liquidity of today as the best estimate for its liquidity tomorrow. Our approach generates significantly lower forecasting errors and is much better able to capture the premium for expected liquidity in bond yields. We provide evidence that investors in corporate bond funds actively anticipate liquidity deterioration in underperforming funds and sell their shares in advance to secure a first-mover advantage.
Way of Life of Thais in Germany

This article examines the way of life of Thais in Germany. The qualitative approach was applied for data collection in June 2018 by in-depth interview and observation. Data were analyzed by the content analysis method. The results found that the way of life of the Thai family in Germany comprised of 3 dimensions 1) Economics dimension: they own the shops (massage shop, karaoke, and restaurant) and work as labour. 2) Social and Cultural dimension: they have networks (sharing information about rights and sources of working) and they practice the Thai cultures to maintain Thainess.
Quality Evaluation of Clinical Practice Guidelines for Comprehensive Patient Assessment in Emergency Care: A National Cross-sectional Survey

Background Clinical practice guidelines (CPGs) provide guidance for emergency care clinicians to perform patient assessments. Neglecting CPGs may lead to incomplete or fragmented assessments and cause ad-verse events. However, it is important for CPGs to be evidence based, and patient assessments must be conducted in such a manner that high levels of patient safety can be achieved. The aim of this study was to explore and evaluate the quality of emergency medical services (EMS) and emer-gency departments (EDs) CPGs for comprehensive patient assessments. Methods A national cross-sectional design was used, and the listed managers from 97 organizations (25 EMS and 72 EDs) were contacted, covering all 20 Swedish county councils. Fifteen guidelines were ap-praised using the validated Appraisal of Guidelines for Research & Evaluation II (AGREE II) tool. Results The results revealed that none of the CPGs outlined a comprehensive patient assessment. The main characteristic of the CPGs was their focus on the medical assessment of patients with life-threatening conditions, mostly based on initial assessment and the A-E principle (airway, breathing, circulation, disability, and exposure). According to the AGREE II analysis, the overall quality of the guidelines was poor. CPGs lacked scientific support, underlying evidence, descriptions of how that evidence was collected, and explanations of the criteria used for CPG development. Conclusions This research indicated that there were no Swedish CPGs with comprehensive patient assessments in emergency care and that the foundation for evidence-based CPGs for comprehensive patient assessments was weak.
MRI-guided Radiotherapy Identifies Early Pseudoprogression of Glioblastoma

Background The standard glioblastoma treatment paradigm consists of surgery, pre-radiotherapy MRI, six weeks of chemoradiotherapy, followed by post-radiotherapy MRI and continued adjuvant temozolomide. In a significant proportion of patients, post-radiotherapy MRI demonstrates tumor enlargement due to either treatment failure (true progression) or treatment response (pseudoprogression). Recently introduced MRI-guided radiotherapy systems obtain daily MRI of glioblastoma patients, and we hypothesized that progression can be identified early during radiotherapy.Methods Fourteen glioblastoma patients underwent tri-Cobalt-60 MRI-guided radiotherapy in 30 fractions over 6 weeks delivered with concurrent temozolomide. The tumor target volume was delineated on MRI before each of the 30 fractions. The images obtained by the 0.35 T MRI-guided system is shown to be similar to T2-weighted images obtained by a clinical diagnostic MRI-scanner. Hyperintense volumes were measured over time through radiotherapy.Results Four of fourteen patients demonstrated increases of at least 25% and 1.5 cc in T2 hyperintense volume through radiation therapy. This volume expansion correlated with both T2/FLAIR and contrast-enhanced volume expansion on post-radiotherapy diagnostic MRIs. In three of four cases, significant volume growth only started at week three of treatment, with the most prominent changes occurring during weeks four and five. While patient numbers are limited, patients with growth during therapy exhibited excellent survival, consistent with the known improved survival of patients with pseudoprogression.Conclusions Daily MRI acquisition during radiotherapy identifies early pseudoprogression typically starting during week 3 or 4 of treatment. This and other daily MRI techniques during radiotherapy could enable early adaptation of therapy in glioblastoma patients.
Biomechanical Effect of 3D-Printed Foot Orthoses in Patients with Knee Osteoarthritis

Lateral wedges are a common conservative treatment for medial knee osteoarthritis (OA). However, use of lateral wedges might increase the ankle eversion moment. To minimize the risk of ankle symptoms, lateral wedges with custom arch support are suggested. However, the manufacturing process of a custom foot orthosis (FO) is complicated, labor-intensive, and time-consuming. The technology of 3D printing is an ideal method for mass customization. Therefore, the purpose of this study was to develop custom FOs using 3D-printing techniques and to evaluate the effects of 3D-printed FOs in patients with knee OA. Fifteen patients with medial knee OA were enrolled into this study. Kinematic and kinetic data were collected during walking by using an optical motion capture system. A paired-sample t-test was conducted to compare biomechanical variables under two conditions: walking in standard shoes (Shoe) and walking in shoes embedded with 3D-printed FOs (Shoe + FO). The results show that the first and second peak knee adduction moments were significantly reduced by 4.08% and 9.09% under the Shoe + FO condition. The FOs alter the biomechanical environment in a way that reduces the variables used to infer abnormal loads at the knee and ankle that could result in painful symptoms.
Clinical features of 35 COVID-19 patients with hospitalization for more than 20 days

Background: As we know, some patients with Coronavirus disease 2019 (COVID-19) may stay longer in the hospital, but whether the different hospitalization days are associated with different clinical features is not clear yet. Methods: This study is a single-centered, observational and retrospective case series.97 patients with COVID-19 were divided into two groups:patients with hospitalization for more than 20 days (Group1,n=35)and those with hospitalization for less than 20 days (Group2,n=62). Data were collected Results Acute Respiratory Distress Syndrome(ARDS) and Hospital acquired pneumonia (HAP)were more common in Group1 than in Group2 . There were more patients administered quadruple antiviral therapy in Group1 than in Group2 . In group1, 14.3% patients’ specimens showed positive again after they were discharged from the hospital.Compared with Group2,Group1 had higher percentages of oxygenation index<300mmHg leucopenia and lymphopenia. In Group1, 19 patients were treated with chloroquine phosphate,whose nucleic acid tests were negative soon,but 5 patents who hadn’t used the medicine had positive testing again . Conclusions: COVID-19 patients with longer hospitalization are more severe and need more quadruple antiviral therapy ;For patients who don't use chloroquine phosphate, the nucleic acid tests are more likely to return to positive again even if they have no symptoms at that time .
Simultaneous determination of four isoflavone compounds in flowers of Pueraria lobata by HPLC

Objective To develop a HPLC method for simultaneous determination of kakkalide,irisolidone,tectorigenin-7-O-xylosylglucoside and biochanin A in flowers of Pueraria lobata.Methods The HPLC analysis was carried out on a Kromasil C18(200 mm×4.6 mm,5 μm) column,with a linearity gradient of 1% acetic acid in water(φ)-methanol-acetonitrile,at the flow rate of 0.8 mL·min-1.The detective wavelength was set at 254 nm,and the column temperature was set at 35 ℃. Results The calibration curve was linear within the range of 42.8-856 mg·L-1 for kakkalide,9.12-182.4 mg·L-1 for irisolidone,13.2-264 mg·L-1 for tectorigenin-7-O-xylosylglucoside and 4.2-84 mg·L-1 for biochanin A,respectively.The average recoveries for four marker compounds were from 98.3% to 100.7%. Conclusions This method is simple,accurate and practical for quality control of flowers of Pueraria lobata.There are some differences in the contents of four marker compounds during the different flowering periods and between different medicinal parts.
Perception of family functionality during social confinement by Coronavirus Disease 2019 / Percepção da funcionalidade familiar durante o confinamento social devido ao Coronavírus 2019

Objective: to assess the perception of family functionality in times of social confinement by Coronavirus 2019 pandemic. Method: it's a descriptive, correlational and cross-sectional study with Portuguese population regarding sociodemographic characteristics, vital cycle phase and application of the Family Assessment Scale Adaptation, Partnership, Growth, Affection and Resolve. Results: the sample consisted of 376 people. The Scale average score is 8.18. Despite the average value indicates a highly functional family, 18.9% of the participants’ present values below, compatible with a family with moderate dysfunction or with severe dysfunction. Conclusions: the pandemic can stimulate awareness about the important role of the family in people's lives and nurses to think of the family as the focus of care and their intervention. Descriptors: Pandemics; Family relations; Coronavirus; Family