Miracle-dz/UniFAR-FTUs huggingface dataset:
Hall instability of solar flux tubes

The magnetic network which consists of vertical flux tubes located in intergranular lanes is dominated by Hall drift in the photosphere-lower chromosphere region ($\lesssim 1 Mm$). In the internetwork regions, Hall drift dominates above $0.25 Mm$ in the photosphere and below $2.5 Mm$ in the chromosphere. Although Hall drift does not cause any dissipation in the ambient plasma, it can destabilise the flux tubes and magnetic elements in the presence of azimuthal shear flow. The physical mechanism of this instability is quite simple: the shear flow twists the radial magnetic field and generates azimuthal field; torsional oscillations of the azimuthal field in turn generates the radial field completing feedback loop. The maximum growth rate of Hall instability is proportional to the absolute value of the shear gradient and is dependent on the ambient diffusivity. The diffusivity also determines the most unstable wavelength which is smaller for weaker fields. We apply the result of local stability analysis to the network and internetwork magnetic elements and show that the maximum growth rate for kilogauss field occurs around $0.5 Mm$ and decreases with increasing altitude. However, for a $120 G$ field, the maximum growth rate remains almost constant in the entire photosphere-lower chromosphere except in a small region of lower photosphere. For shear flow gradient $\sim 0.01 s^{-1}$, the Hall growth time is 10 minute near the footpoint. Therefore, network fields are likely to be unstable in the photosphere, whereas internetwork fields could be unstable in the entire photosphere-chromosphere. Thus the Hall instability can play an important role in generating low frequency turbulence which can heat the chromosphere.
Re-Challenge with Sonidegib after Vismodegib Discontinuation in a Near- Centenarian Patient with Locally Advanced Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the most common form of skin cancer, mostly affecting eldery patients and carrying an excellent prognosis [1]. The first line treatment is usually represented by surgical excision, but, for those patients not eligible for surgery or radiotherapy, Hedgehog (HH) inhibitors represent a safe and efficient therapeutic option [1]. The aberrant activation of HH signaling underlies the pathogenesis of BCC [2]. This aberrant activation is due to a loss of function of PTCH1, which normally acts to inhibit the signaling activity of SMO, a seven-transmembrane protein. Following the pivotal ERIVANCE BCC study, the small molecule inhibitor of SMO Vismodegib was the first drug to be approved in the USA and Europe for the treatment of locally advanced (laBCC) or metastatic BCC [3]. The second SMO inhibitor, approved in 2015, was the small molecule sonidegib. Results from the BOLT study demonstrated efficacy and tolerability in the treatment of laBCC [4].
Gravity model estimation: fixed effects vs. random intercept Poisson pseudo-maximum likelihood

ABSTRACT The standard Anderson and van Wincoop gravity model has typically been estimated using a fixed-effects approach. However, a fixed-effects approach has a major drawback: it does not allow for the estimation of exporter- and importer-invariant variables. Thus, at least in a cross-sectional context, economically relevant variables such as exporter and importer gross domestic product are disregarded. We propose a random intercept model to address this gap. For large datasets, this approach not only provides identical estimates like a fixed-effects approach, but also allows for the estimation of exporter- and importer-invariant variables.
Underpricing Anomaly in Initial Public Offerings: An Application on Borsa İstanbul Health Sector

The phenomenon of underpricing in initial public offerings has been one of the topics debated in the literature for a long time. Examining underpricing, which is an example of price anomalies, and analyzing its determinant factors are vitally important for the establishment of efficient capital markets. The aim of this study is to contribute to the existing literature on the underpricing anomaly observed in initial public offerings. For this purpose, the initial public offerings of companies in the health sub-sector whose stocks are traded in Borsa Istanbul for the period 2006 – 2021 are examined. The short-term price performance of the stocks included in the sample after the initial public offering is analyzed. The main problem for which the answer is sought in the study is whether an investor who buys stocks from the issuance in the initial public offering of the sample companies can get more returns than the market when they hold and sell these stocks for a short period of time. The change in the initial returns of the initial public offerings of health companies, especially as a result of increasing health awareness after Covid-19, is also examined. In the analysis, raw retıurn (RR), abnormal return (AR), cumulative abnormal return (CAR) and compound abnormal returns (BHAR) are calculated during the 1, 3 and 7 days, which are considered as analysis period. If the AR, CAR and BHAR calculated in the analysis are greater than 0 and the their values are statistically significant according to the t-test result, the existence of underpricing can be accepted. According to the results of the analysis, a underpricing anomaly has not been found out in the initial public offerings of the health companies that formed the sample. Based on this finding, it can be expected that investors who bought a stock in an initial public offering would not have an abnormal return if they held it in portfolio basket for 1, 3, and 7 days of the analysis period. It can be recommended that investors not to choose health sector companies while investing in the public offering in terms of obtaining positive higher returns.
Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review

Dengue is a vector-borne disease caused by the dengue virus (DENV) and is a major health concern worldwide, particularly in regions of endemic disease. Dengue usually presents as a self-limited febrile illness. In some cases, more severe forms with hemorrhage and shock can occur, and children are especially prone to develop it. These forms can be lethal without appropriate management, and no antiviral treatment exists today. In the absence of a curative treatment for dengue, its clinical prevention remains essential. One vaccine - the chimeric yellow fever-dengue-tetravalent dengue vaccine (CYD-TDV) - has been approved for use in some populations, and several others are currently in development, including Takeda's tetravalent dengue vaccine candidate (TAK-003). This study is a systematic review of the current literature realized to evaluate the efficacy of the dengue vaccines in preventing severe dengue in children. This review focuses on the vaccines CYD-TDV and TAK-003. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, PubMed Central (PMC), Medical Literature Analysis and Retrieval System Online (MEDLINE), Cochrane Library, and Google Scholar were the databases used to find the relevant data. The articles were selected using specific inclusion and exclusion criteria, and quality appraisal was realized with standardized quality assessment tools. Overall, our study shows that the dengue vaccines CYD-TDV and TAK-003 confer protection against severe dengue in children. Some distinctions exist depending on the vaccine type, the age, and the dengue serostatus of patients. While demonstrating encouraging results, this review also emphasizes the need for more in-depth studies about the safety and efficacy of dengue vaccines.
Fundamental study into the governing conditions of rotor thermal bows in hydrodynamic bearings

This thesis presents an experimental investigation into the conditions generated within a high speed bearing system where thermally generated shaft bows can arise from differential journal heating, and under certain condtions this effect has been observed to result in unstable shaft vibration the ‘Morton Effect’. This thesis documents the development of a simplified analytical procedure for evaluating the thermal activity within an orbiting journal when running in hydrodynamic bearings. The aim of this work was to generate controlled experimental data regarding journal differential heating effects to support the understanding and development of appropriate modelling and predictive techniques. A high speed rotor test rig, running in 50mm diameter bearings of fixed and variable geometry configuration, was used to obtain directly measured temperature distributions within the rotor when running under varying speed and unbalance response conditions. Two separate rotor designs were used. The first is designed as a rigid rotor where no structurally influenced rotor dynamic phenomena are present within the running ranges. The second is a flexible rotor designed to operate in a super critical condition where conditions are replicated to provide a rotor that is sensitive to the variables required for thermal bow development and the rotordyanmic conditions promotional of associated instabilities. Existing theoretical models, in combination with operationally observed characteristics, were used to develop a design predicted to become unstable within the test running range. Journal temperature measurements were obtained for rigid and flexible rotors over a range of speed conditions in intentionally introduced mechanical unbalance conditions. Journal temperature differentials were obtained with a clear correlation between journal orbit size and journal temperature differential. The flexible rotor was operated for prolonged periods of time in the predicted unstable region but instability was never initiated for any test condition. Peak journal temperature differentials were measured as 1.7 C. A new analytical model for the bearing oil film and journal thermal developments is presented which has reasonable correlation to other published literature.
Fibronectin as a diagnostic marker in several determined neurological diseases

OBJECTIVE: To determinate if fibronectin in CSF can be a useful parameter in the diagnosis of some neurologic illnesses. MATERIAL AND METHODS: We have studied 30 patients, subdivided in four groups, depending on the type of neurologic illness. We have chosen as control a 10-patient group, which came to the Emergency Service and were diagnosed as a suspicious of neurologic illness, but after this it was discarded. In the whole group we practiced a lumbar puncture, with cytology, systematic, biochemistry, cultures, immunoglobulins determination and fibronectin quantification by ELISA. RESULTS: We want to emphasize the increase in fibronectin levels in CSF in both the patients with bacterial meningitis and the multiple sclerosis groups, when it's compared with the control group. CONCLUSION: For this, the determination of fibronectin levels in CSF might be a useful parameter in the diagnosis of some neurologic illnesses.
Unicystic Mucoepidermoid Carcinoma: A Pitfall for Clinical and Pathologic Diagnosis

Unicystic mucoepidermoid carcinoma (UC-MEC) is a rare MEC variant, and its diagnosis is frequently problematic. This study is aimed at summarizing its clinicopathologic characteristics, treatment, and prognosis and proposing key points to avoid missed diagnosis and misdiagnosis in clinical and pathological conditions. This retrospective study included 30 UC-MEC cases, and the clinical findings were collected from the clinical medical records. Radiographic features, histologic behaviors, MAML2 rearrangement by fluorescence in situ hybridization (FISH), and follow-up data were analyzed. Moreover, glandular odontogenic cyst (GOC) and cytadenoma (CA) were used as controls. In the UC-MEC group, 19 patients were female (63%), and 11 were male (37%). The mean patient age was 39.5 (range, 7–72 years). The affected locations included the jaw (8 maxillary, 3 mandibular) and salivary glands (7 parotid, 11 palates, and 1 floor of the mouth). The chief complaint was swelling; the lesions were all cystic, among which 66.7% were well circumscribed and 33.3% poorly defined. Microscopic examination showed two UC-MEC histologic subtypes. Type A presented as a single cyst with mural thickening (8/30, 27%) lined predominantly by epidermoid cells with interspersed intermediate and mucinous cells, and type B (22/30, 73%) showed infiltrative tumor islands in the cystic wall or the surrounding tissue. FISH analysis suggested that approximately 66.7% of UC-MEC harbored a MAML2 rearrangement. During the median follow-up period of 42 months (range, 6–120 months), all type A patients and 68% of type B patients who underwent complete surgical resection lived without relapse. Seven cases with type B cancer that underwent curettage initially had local recurrence. Clinicians and pathologists hardly recognize UC-MEC owing to its cystic architecture. Specific epidermoid, mucous, and intermediate tumor cells, and MAML2 fusion testing, are essential to avoid potential diagnostic pitfalls. Prompting and completing resection surgery with negative margins would have a favorable prognosis.
Many flavor QCD with N_f=12 and 16

Information of the phase structure of many flavor SU(3) gauge theory is of great interest for finding a theory which dynamically breaks the electro-weak symmetry. We study the SU(3) gauge theory with fermions for $N_f=12$ and 16 in fundamental representation. Both of them, through perturbation theory, reside in the conformal phase. We try to determine the phase of each theory non-perturbatively with lattice simulation and to find the characteristic behavior of the physical quantities in the phase. HISQ type staggered fermions are used to reduce the discretization error which could compromise the behavior of the physical quantity to determine the phase structure at non-zero lattice spacings. Spectral quantities such as bound state masses of meson channel and meson decay constants are investigated with careful finite volume analysis. Our data favor the conformal over chiral symmetry breaking scenario for both $N_f=12$ and 16.
Alterations in Baroreflex Sensitivity and Blood Pressure Variability Following Sport-Related Concussion

Current methods to diagnose concussions are subjective and difficult to confirm. A variety of physiological biomarkers have been reported, but with conflicting results. This study assessed heart rate variability (HRV), spontaneous baroreflex sensitivity (BRS), and systolic blood pressure variability (BPV) in concussed athletes. The assessment consisted of a 5-min seated rest followed by a 5-min (0.1 Hz) controlled breathing protocol. Thirty participants completed baseline assessments. The protocol was repeated during the post-injury acute phase (days one to five). Total (p = 0.02) and low-frequency (p = 0.009) BPV spectral power were significantly decreased during the acute phase of concussion. BRS down-sequence (p = 0.036) and up-sequence (p = 0.05) were significantly increased in the acute phase of concussion, with a trend towards an increased BRS pooled (p = 0.06). Significant decreases in HRV were also found. Acute concussion resulted in altered BRS and BPV dynamics compared to baseline. These findings highlight objective physiological parameters that could aid concussion diagnosis and return-to-play protocols.
The effect of IFRS on the financial ratios: Evidence from banking sector in the emerging economy

Abstract Financial ratios are ratios that are used to measure a company’s performance by analyzing its financial records. In light of this claim, this study investigates the effect of IFRS on the financial ratios among seventeen (17) Ethiopian commercial banks. The research hypotheses are addressed by comparing financial ratios computed under Ethiopian GAAP with those computed under the IFRS regime from 2016 to 2020 using Wilcoxon Signed Rank and the Normality Test. The finding revealed that IFRS has a significant effect on the liquidity ratio of commercial banks in Ethiopia, and banks reported higher liquidity under IFRS than under Ethiopian GAAP. The finding also revealed that IFRS has a significant effect on commercial banks’ return on equity and that banks recorded a higher return on equity under IFRS than under Ethiopian GAAP. Moreover, the study found IFRS has a significant effect on the leverage ratio of commercial banks in Ethiopia, and banks reported lower leverage under Ethiopian GAAP than under IFRS. However, the finding revealed that IFRS has an insignificant effect on the return on assets of commercial banks in Ethiopia, and banks recorded a lower return on assets under IFRS than under Ethiopian GAAP. The study concluded that the difference in return on equity, liquidity, and leverage of commercial banks following the adoption of IFRS is significant. Therefore, investors and financial analysts should pay close attention to the return on equity (ROE), liquidity ratio (LR), and leverage (LEV) because they are significantly affected by the adoption of IFRS.
Digestate Potential to Substitute Mineral Fertilizers: Engineering Approaches

The study aims to define the potential and technological aspects of the digestate treatment for its application as a biofertilizer. Life cycle assessment methodology was used in terms of digestate quality management. The potential of nutrients, organic carbon, and useful microelements in the digestate allows for its consideration as a mineral fertilizer substitute and soil improver. The valorization of digestate as fertilizer requires quality management and quality control. Based on the research focus, the successful soil application of digestate post-treatment technologies was analyzed. Among the different commercial options for digestate treatment and nutrient recovery, the most relevant are drying, struvite precipitation, stripping, evaporation, and membranes technology. Comparing the physical and chemical properties of the whole digestate, separated liquid, and solid liquor fractions showed that in the case of soil application of granular fertilizer, nutrients from the digestate are released more slowly than digestate application without granulation. However, realizing this potential in an economically feasible way requires improving the quality of digestate products through appropriate technologies and quality control of digestate products. To support the manufacture of quality digestate across Europe, the European Compost Network developed a concept for a pan-European quality assurance scheme.
COMPUTER SIMULATION OF MAGNETIC PROPERTIES OF SPRING MAGNETS

Magnetic properties of model exchange-spring magnets, which are composed of magnetically soft and hard grains, were calculated by means of computer simulation. The dependence of the magnetic properties on the strength of intergrain exchange interaction and the amount of soft grains was studied. The existence of soft grains enhanced the remanence remarkably, and the remanence over 0.8Ms was obtained in the model magnets containing 25% or more soft grains by volume. The calculated coercivity vs. the strength of the exchange interaction curves showed a peak at a critical strength of the exchange interaction, although the remanence increased monotonously with increase in the strength of the exchange interaction. Thus the maximum energy product also reached a peak around the same critical strength. The calculated maximum energy product exceeded 300kJ/㎥ when the magnet is assumed to be composed of Fe₃B and Nd₂Fe₁₄B.
Trends in Medical Training and Leadership at Academic Orthopedic Programs

Introduction: When deciding on which programs to rank or fellowships to enter, medical students and residents may assess the program's prestige and specialty training opportunities. This report aimed to analyze the demographics of orthopedic department chairs and program directors (PDs), focusing on the prestige of their orthopedic training and medical school. Secondary data included fellowship, higher-level education, sex, professorship, years of practice, and total published research. Methods: We used U.S. News and Doximity to rank 192 medical schools and 200 orthopedic residency programs based on prestige rankings, respectively. We searched for the department chair, vice-chair, and PD via program websites, Council of Orthopaedic Residency Directors (CORD), Orthopedic Residency Information Network (ORIN), personal websites, LinkedIn, and Doximity. Subsequently, we searched for each individual’s demographic information, education and research history, employment history, and medical school attended. Results: We gathered data on 268 orthopedic surgeons with leadership positions at academic hospitals. Of the 268, 115 were department chairs, 15 were vice-chairs, 126 were PDs, 11 were both the chair and PD, and one was vice-chair and PD. Of the 268 physicians, 244 physicians were male (91.0%), while 22 were female (9.0%). The average residency reputation ranking overall was 59.7 ± 5.7. More specifically, for chairs, the average was 57.0 ± 8.3 (p < 0.005), and for PDs, the average was 63.6 ± 8.0 (p <0.005). There was no significant difference between chairs and PDs (p = 0.26). Conclusion: Orthopedic leaders were found to have trained at more prestigious programs. This trend could be explained by increased research opportunities at more prestigious programs or programs attempting to increase their own reputation. 9.0% of the leaders identify as female, which is comparable to the 6.5% of practicing female orthopedic surgeons. However, this further demonstrates a need for gender equity in orthopedic surgery. Assessing trends in the training of orthopedic surgeons with leadership positions will allow a better understanding of what programs look for in the hiring process.
Experimental studies of impulse noise produced by spheres moving through water

Abstract : It is known from previous experiments that freely falling spheres produce sudden noise bursts. The source of this noise is unknown and little is known about the conditions under which it occurs. In an attempt to study this phenomenon under controlled conditions, spheres were towed in an anechoic tank, Velocities up to 5 m/sec and Reynolds numbers up to 500,000 were obtained with spheres of 2, 4 and 10 inches diameter. After eliminating all mechanical and acoustical disturbances, no noise bursts could be detected. However, the impulsive noise was still observed in free-fall experiments, and a ranging system allowed the location of these noise bursts with respect to a fixed point. A frequency analysis was done with a digital signal processor.
How Determinants of the Human Development Index Impact Indonesia

The purpose of this research is to achieve success in the development process carried out by local and central governments, of course, as the right regulators in economic activities. Success in building HDI is largely determined by the full commitment of the government as a provider of facilities and infrastructure and fully understands that to achieve a modern economy, the quality of life of human resources must be improved. This research was carried out on the problems that occurred in several regions in Indonesia, the existence of inequality in both economic growth and human quality development in the western and eastern regions of Indonesia, a more visible phenomenon is that in several regions of Indonesia there has been looped economic growth and looped human development. This type of research is quantitative research, the subjects in this study are all provinces in Indonesia. The type of data used is secondary data using panel data from 34 provinces during 2015–2019. Data collection techniques were used observation and documentation. The data analysis technique is simultaneous analysis. The results of this research show that variables of education, government spending on education, economic growth, and poverty together have a significant influence on human development.