Miracle-dz/UniFAR-FTUs huggingface dataset:
Interval cancer audit and disclosure in cervical screening programmes: An international survey

Background Legal cases involving the National Cervical Screening Programme in Ireland following non-disclosure of an interval cervical cancer audit prompted this first international comparative survey of interval cervical cancer audit. Methods A survey of 22 international population-based cervical screening programmes was conducted, to determine if they undertook audit of invasive cervical cancers. Those countries/regions that perform reviews were asked (i) how the audit was undertaken, including how the reviews were performed and how they controlled for retrospective bias, (ii) how women are informed of the audit process and how their consent is obtained, and (iii) how audit results were disclosed to patients. Results Seventeen countries/regions invited completed the survey (77%); 65% (11/17) have an audit process for interval cervical cancers. Five perform individual patient reviews; three perform programme-wide review, with calculation of interval cancer detection rates; one routinely performs programme-wide review with calculation of interval cancer detection rates and offers individual reviews, and one routinely performs local hospital-level reviews. In the remaining country/region, hospital laboratories audit cancers, with a national audit process for all cervical cancers. Varying methodologies for retrospective cytology review were employed; four include control samples, with a ratio varying from 1:1 to 1:2. Three conduct a blinded review. Most countries/regions do not discuss interval cancer audit with participants and 3/11 (27.3%) inform women when a cervical cancer audit takes place. Disclosure is limited and variable. Conclusion The responses suggest that there is no consistent approach to audit of interval cervical cancers or to disclosure of audit results.
Co-culture of peripheral blood mononuclear cell (PBMC) and human coronary artery endothelial cell (HCAEC) reveals the important role of autophagy implicated in Kawasaki disease

Background Kawasaki disease (KD) is a systemic vasculitis syndrome that commonly occurs in children. Autophagy has been increasingly shown to be involved in various cardiovascular diseases, including endothelial dysfunction and vascular endothelial injury. However, whether autophagy is implicated in the pathogenesis of KD remains poorly understood, and particularly, how the dysfunction of human coronary artery endothelial cells (HCAECs) is associated with autophagy in peripheral blood mononuclear cells (PBMCs) from KD patients awaits further investigation. Methods Peripheral blood samples were collected from KD patients, common fever patients, and healthy controls. The PBMC samples were isolated from KD blood samples collected at three different phases: the acute phase before therapy (acute-KD), 1 week (subacute-KD), and 4 weeks (convalescent-KD) after drug administration. Results The autophagy flux was significantly increased in the PBMCs of KD patients at acute phase. The PBMCs of acute KD patients could induce autophagy in HCAECs and promote the secretion of chemokines and pro-inflammatory factors after cocultured with HCAECs whereas 3-methyladenine (3-MA) drug could partly reverse this process. Conclusions Autophagy is involved in the inflammatory injury of vascular endothelial cells associated with PBMCs in KD patients, and may play a crucial role in regulating inflammation. Hence, we identify a novel regulatory mechanism of vascular injury in this disease.
Flutter Margin Evaluation for Discrete-Time Systems

A flutter prediction method using a new parameter is proposed, and its effectiveness is examined by numerical and experimental analysis. In this method, the aeroelastic system is identified as the autoregressive moving average (ARMA) model from the random response of a wing excited by flow turbulence, so that no special excitation device is needed. The new parameter is based on a stability test for discrete-time systems and is calculated algebraically from the autoregressive coefficients of the estimated ARMA model. Numerical calculation using a two-dimensional wing model shows that the parameter decreases almost linearly toward zero with increasing dynamic pressure. This is a superior property as a flutter predictor in comparison with damping coefficients and the stability parameter used conventionally. The method is applied to supersonic wind-tunnel flutter test data to examine the validity in actual data analysis. The results obtained under different test conditions demonstrate the advantage of the present method for an accurate and reliable flutter prediction. Moreover, an analytical consideration reveals that the calculated values of the proposed parameter are nearly equal to that of the flutter margin introduced by Zimmerman and Weissenburger (Zimmerman, N. H., and Weissenburger, J. T., Prediction of Flutter Onset Speed Based on Flight Testing at Subcritical Speeds, Journal of Aircraft, Vol. 1, No. 4, 1964, pp. 190-202).
Clinical and Radiographic Evaluation of the Labial Bone Plate after Using Plasma Rich Fibrin in Immediate Implant in Esthetic zone

The benefits of immediate implant insertion after tooth extraction are elimination of post-extraction healing period, reduction of the number of surgical sessions, preservation of alveolar width and height and lower risk of dehiscence or fenestrations around dental implant. Moreover, better angulation leading to improved esthetics and axial occlusal loading and improved surgical orientation relative to pertinent anatomical structures were obtained[1].
Altered functional connectivity density and couplings in postpartum depression with and without anxiety

Abstract Postpartum depression (PPD) is the most common psychological health issue among women, which often comorbids with anxiety (PPD-A). PPD and PPD-A showed highly overlapping clinical symptoms. Identifying disorder-specific neurophysiological markers of PDD and PPD-A is important for better clinical diagnosis and treatments. Here, we performed functional connectivity density (FCD) and resting-state functional connectivity (rsFC) analyses in 138 participants (45 unmedicated patients with first-episode PPD, 31 PDD-A patients and 62 healthy postnatal women, respectively). FCD mapping revealed specifically weaker long-range FCD in right lingual gyrus (LG.R) for PPD patients and significantly stronger long-range FCD in left ventral striatum (VS.L) for PPD-A patients. The follow-up rsFC analyses further revealed reduced functional connectivity between dorsomedial prefrontal cortex (dmPFC) and VS.L in both PPD and PPD-A. PPD showed specific changes of rsFC between LG.R and dmPFC, right angular gyrus and left precentral gyrus, while PPD-A represented specifically abnormal rsFC between VS.L and left ventrolateral prefrontal cortex. Moreover, the altered FCD and rsFC were closely associated with depression and anxiety symptoms load. Taken together, our study is the first to identify common and disorder-specific neural circuit disruptions in PPD and PPD-A, which may facilitate more effective diagnosis and treatments.
Rail infrastructure : Challenges for cost-benefit analysis and other ex ante evaluations

Cost--benefit analysis (CBA) plays a major role in the ex ante evaluation of rail projects in many western countries. At first sight carrying out a CBA for rail projects seems straightforward, since cost estimates are almost always available, and the most dominant benefits are generally known, being the travel time saved and the increase in consumer surplus due to induced demand. However, the practice is much more complex: the quality of current estimates for costs and benefits is often poor and several benefits-related aspects are ignored. This article gives an overview of the challenges in improving the quality of CBAs for rail projects.
Contractual Governance: Effects of Risk Allocation on Contractors’ Cooperative Behavior in Construction Projects

AbstractWhen designing contracts in practice, project owners often allocate excessive risks to contractors. Although previous studies have suggested that such improper risk allocation may harm the relationship between the owner and the contractor and thus lower project performance, few have explicitly investigated the effects of risk allocation on the contractor’s cooperative behavior. This paper fills this gap by empirically exploring whether, how, and when risk allocation influences the contractor’s cooperative behavior. To do this, data were collected from 284 Chinese project professionals and hierarchical regression analysis was performed. The results show that pro-owner contractual terms with regard to risk allocation negatively affect the contractor’s cooperative behavior, and the contractor’s fairness perception partially mediates such an effect. Moreover, risk premium weakens the effect of environmental risks allocation on the contractor’s fairness perception, and term specificity strengthens the .
Modern Apprenticeship, Process and Learning: Some Emerging Issues.

ABSTRACT The Modern Apprenticeship programme in the United Kingdom has been broadly welcomed by employers, training providers, and commentators on the vocational education and training scene. A shift in policy focus has been detected from an emphasis on ‘outcomes’ (qualifications), which has come to dominate post‐16 provision, towards a rediscovery of ‘process’. One reason for this is that, at least at the level of policy, the Modern Apprenticeship can be linked to the challenges posed by a post‐Fordist analysis of the relationship between the economy, work and skills. The paper identifies some of the features of Modern Apprenticeship and discusses three learning‐related issues which emerged during development work for one sector's Modern Apprenticeship. It is argued that effective management and delivery of the learning process can be achieved through closer partnerships between employers and training providers. Relying on the measurement of outcomes alone, is likely to prove an inadequate approach to en.
Sensitivity of Modeled Nearshore Morphology to Wave and Sediment Transport Formulations

Two models are discussed that describe the initial forma- tion of nearshore large-scale rhythmic morphology due to feedbacks between the wave-driven large-scale ∞ow and the erodible bottom. The aim is to gain fundamental knowledge about the sensitivity of modeled bar characteristics to the description of waves and sediment transport, in case of obliquely incident waves and planar reference beach proflles. The two models difier mostly in the wave description (with difierent degrees of complexity) and both of them are supplied with two difierent sediment transport formulations. Systems of sand bars with longshore rhythmicity emerge as free instabilities of the sys- tem. Including randomness in wave heights largely afiects the mod- eled bar growth and dynamics. Results are also difierent for the two sediment transport formulations. In particular, the difierences in the cross-shore distribution of the wave stirring function lead to difierent characteristics of the fastest growing modes.
Using auditory and tactile displays for force feedback

Traditional force feedback or force reflection, which applies forces to a human operator's hand or arm muscles, has been shown in several studies to be beneficial to a person performing remote manipulation tasks with a teleoperation system. However, force reflection can have its disadvantages including operator induced instabilities in the presence of time delays. The use of tactile and auditory displays to present force feedback will be discussed. These displays can provide the human operator with force information without some of the disadvantages of force reflection. The design of the displays are explained, as well as an experimental study on the effectiveness of the displays for remote manipulation tasks. These displays compared favorably to traditional force reflection for basic force perception tests, and improve the human operator's sensitivity for detecting small forces. With a time delay, the displays improved operator performance for peg-in-hole tasks without instabilities. They also improved performance during degraded visual conditions. The benefits of using such displays for telemanipulation tasks is discussed, as well as potential applications and future research.
Partial H-plane filters with partially inserted H-plane metal vane

A partial H-plane filter, which can be compared with a conventional E-plane filter, is proposed as a new type of compact direct-coupled resonator filter. The partial H-plane filter has the same frequency response as that of the E-plane filter while its cross section is one quarter. Measured results are in good agreement with computed results.
Negative effects of the feral donkey Equus asinus (Linnaeus, 1758) in Al-Ula governorate, western Saudi Arabia

Alien animals cause drastic and negative impacts on biota and ecosystems. The feral donkey Equus asinus is an invasive alien species in Saudi Arabia. Damage of farms and plant consumed by feral donkeys were studied in the area between Al-Ula and Al-Wajh governorates in order to spot their harmful effects in this region and to propose possible solutions to the problems they caused. Surveys and direct interviews and conversations with farmers and villagers were the selected methods used to collect information. Prevention, and management actions were suggested to decrease numbers of feral donkeys. A useful investment potential was proposed to get some benefits from them.
Physiological and Genetic Variation of Hordeum vulgare L. and Triticum aestivum L. Lines Planted in Turkey

: Hordeum vulgare L. (barley) and Triticum aestivum L. (wheat) are among the most valuable crops cultivated and planted in many regions including Turkey. These plants have wide range of adaptation ability and capacity; they represent high level of variation in terms of physiological, genetics and epigenetics parameters and characteristics. Physiological and genetic variations were investigated by relative water content (RWC) assays, measuring electroconductivity (EC) levels and amplification of microsatellite markers in 21 barley and 43 wheat lines. At least three drought sensitive and three drought resistant lines were detected in barley and wheat lines via RWC assays. RWC values were recorded between 0.05±0.013 and 0.55±0.003%. Similarly great variation was detected for EC values of both barley and also wheat lines. Minimum and maximum EC values were ranged from 4.00±0.06 μS cm-1 to 59.88±3.209 μS cm-1. Three microsatellite markers, Bmag0120, Bmag0306 and Bmag375, were targeted in barley genome. Similarly, Han18, Wmc506 and Wmc623 microsatellite markers were targeted in wheat genome. Among these markers only Bmag0120 and Han18 were amplified from each line’s genome by PCR and qPCR assays. In PCR and qPCR analysis homozygous and heterozygous lines were detected for Bmag0120 while each line was homozygous for Han18. Idiomorphic band size as 300 bp was detected in Han18 while it was ranged from 224 to 279 bp for Bmac0120 marker. Results showed that homozygous lines were drought resistant ones in barley lines whereas no correlation was found for wheat lines investigated in this study.
On-site diagnosis of power transformers by means of relaxation current measurements

The purpose of this paper is to show how the relaxation currents of a power transformer can be calculated, when the geometrical configuration of the main insulation and the dielectric properties of its components, oil and pressboard, are known. To model this insulation a simple equivalent circuit is presented, which is derived from basic relations of linear dielectric theory. The dielectric characteristics of oil and pressboard necessary for modelling are determined from dielectric response measurements on samples. Therefore some results of relaxation current measurements of pressboard samples in dependence on moisture content and temperature are presented. Finally, some examples of on-site measurements of relaxation currents on hitherto unused power transformers are shown which are used here to demonstrate how the moisture content of pressboard of these transformers can be quantified from evaluation of their relaxation currents.
Peak Vehicle Miles Traveled and Postpeak Consequences?

The purpose of this paper is twofold: first, to summarize changes in travel that account for the decline in total roadway vehicle travel from the previous decade's peak levels and, second, to speculate on the implications of postpeak vehicle miles traveled trends. Both sections of the paper are speculative. The lack of available data makes it difficult to diagnose fully the changes in travel behavior that result in lower levels of roadway travel. Planners are only beginning to think about the impacts of no growth in roadway travel. The paper evaluates travel trends, by addressing freight versus passenger travel, urban versus rural, mode choice, age, income, communication substitution, and logistics as factors affecting vehicle miles traveled. Consequences include transportation capacity requirements, transportation infrastructure productivity, induced demand, transportation land use, transportation and economic development, challenges for traditional planning processes, equity implications, and risk and uncertainty.
RKIP Pleiotropic Activities in Cancer and Inflammatory Diseases: Role in Immunity

Simple Summary The human body consists of tissues and organs formed by cells. In each cell there is a switch that allows the cell to divide or not. In contrast, cancer cells have their switch on which allow them to divide and invade other sites leading to death. Over two decades ago, Doctor Kam Yeung, University of Toledo, Ohio, has identified a factor (RKIP) that is responsible for the on/off switch which functions normally in healthy tissues but is inactive or absent in cancers. Since this early discovery, many additional properties have been ascribed to RKIP including its role in inhibiting cancer metastasis and resistance to therapeutics and its role in modulating the normal immune response. This review describes all of the above functions of RKIP and suggesting therapeutics to induce RKIP in cancers to inhibit their growth and metastases as well as inhibit its activity to treat non-cancerous inflammatory diseases. Abstract Several gene products play pivotal roles in the induction of inflammation and the progression of cancer. The Raf kinase inhibitory protein (RKIP) is a cytosolic protein that exerts pleiotropic activities in such conditions, and thus regulates oncogenesis and immune-mediated diseases through its deregulation. Herein, we review the general properties of RKIP, including its: (i) molecular structure; (ii) involvement in various cell signaling pathways (i.e., inhibition of the Raf/MEK/ERK pathway; the NF-kB pathway; GRK-2 or the STAT-3 pathway; as well as regulation of the GSK3Beta signaling; and the spindle checkpoints); (iii) regulation of RKIP expression; (iv) expression’s effects on oncogenesis; (v) role in the regulation of the immune system to diseases (i.e., RKIP regulation of T cell functions; the secretion of cytokines and immune mediators, apoptosis, immune check point inhibitors and RKIP involvement in inflammatory diseases); and (vi) bioinformatic analysis between normal and malignant tissues, as well as across various immune-related cells. Overall, the regulation of RKIP in different cancers and inflammatory diseases suggest that it can be used as a potential therapeutic target in the treatment of these diseases.
Conceptions of sexuality of adolescents living in residence cares: are their interests and curiosities different?

The institutionalization of children and adolescents generally is due to unfavourable socio-economic conditions, children maltreatment, school absenteeism and adolescents’ behavioural problems, including sexual risk behaviours. Sexuality education (SE) is very difficult to approach in residence care, given the sensitive and problematic life stories of adolescents involved. It is important to know what adolescents already know and what they want to learn and clarify about sexuality. The research question was: What interests and curiosities of sexuality do adolescents living in residence care have? The objectives were to make a diagnosis of adolescents’ interests, needs and conceptions about sexuality and to relate these conceptions with individual factors. A transversal study was done following a quantitative methodology. A questionnaire was carried out for this research. Dependent variables were: sources of information about SE; perceptions about the role of SE on children and adolescents’ development; responsible intervener for SE; sexuality topics about which adolescents want to learn more. A convenience sample included 114 teens aged between 11 to 21 (mean=15.7±2.4; 68 females and 46 males), living 60,5% of them since more than 24 months ago in residence care. A statistical analysis was done. Results showed that in adolescents’ views, the main role of SE is: to help them to respect different sexual orientations; to understand that sexuality expresses differently along the lifespan; and to promote equal rights and opportunities between men and women. Their main sources of information are friends, internet and familiars with approximately equal age. Persons they consider to be most responsible for their SE are doctors, nurses and mothers, with significant differences for health professionals, girls having a higher preference for them than boys. Topics about which adolescents have more interest and curiosity are: love, friendship and romantic relationships; adolescence; diversity, tolerance, sexual orientation and respect; and sexually transmitted diseases and infections.
Slightly Acidic Electrolyzed Water to Remove Methylobacterium mesophilicum, Rhodotorula mucilaginosa and Cladosporium cladosporioides in Households

(1) Background: Slightly acidic electrolyzed water (SAEW) is an effective and safe sterilizing solution. Its active component is hypochlorous acid (HOCl) which has been proved to exhibit a strong disinfectant activity. In this research we evaluated the effectiveness of SAEW in the removal of Methylobacterium mesophilicum, Rhodotorula mucilaginosa and Cladosporium cladosporioides, responsible for pink-colored biofilm and black mold in households. (2) Methods: Two concentrations of SAEW, 20 mg/L and 40 mg/L, were tested against M. mesophilicum, R. mucilaginosa and C. cladosporioides. In vitro experiments and mesh experiments were conducted to test the effectiveness of SAEW. (3) Results: The test results showed that 40 mg/L SAEW was effective in removing R. mucilaginosa and C. cladosporioides, with the population decreasing by approximately two orders of magnitude. For M. mesophilicum, resistance towards SAEW was observed; to obtain a 1.3 order of magnitude decrease in bacterial population, washing 5 times with 40 mg/L SAEW was necessary. Mesh experiments showed that SAEW can remove black mold; (4) Conclusions: Overall results indicated that SAEW was particularly effective for R. mucilaginosa and C. cladosporioides species commonly found in Japanese households.