Miracle-dz/UniFAR-FTUs huggingface dataset:
Hydrobiological Characterization of Guanabara Bay

Guanabara Bay forms an ecological unity with serious environmental problems derived from an accelerated and unorganized process of urbanization without the necessary support. The UFRJ/Institute of Biology soon became aware of these problems and since 1985 it has been developing systematic studies about the bay. Based on data obtained from previous isolated studies, a new project was elaborated so as to establish the systematization and planning of a series of field studies which would finally furnish the hydrobiological characterization of the bay. This paper discusses general aspects of the bay, study methodology, and study results. Among the conclusions drawn thus far are that the low water quality, accompanied by high Cyanophyceae concentrations and frequent phytoplanktonic blooms, indicates that the bay undergoes severe environmental stress. The great social-economic importance of Guanabara Bay justifies the high investments necessary for its recuperation.
Cardiothoracic Care Nurses' Practice and Beliefs toward Endotracheal Suction Post Coronary Artery Bypass Graft at Teaching Hospital

Background: Although endotracheal suction (ETS) is a crucial practice, it is not free of complications and hazards particularly when operated improperly or/and critical condition. Therefore, it is particularly important to perform this procedure with professional competence, especially among high risky groups with threatening conditions. Aim: This study aimed to assess cardiothoracic care nurses' practice and beliefs toward endotracheal suction post coronary artery bypass graft at teaching hospital. Materials and Method: A cross-sectional descriptive study conducted at cardiothoracic care unit (CTCU) at the teaching hospital. A convenience sample of thirty-two nurses utilized self-administrated scale to assess nurses’ beliefs and observational checklist to assess their level of practice toward Endotracheal Suction Post Coronary Artery Bypass Graft at Teaching Hospital. Results: Mostly of the studied nurses were female and had technical institutions. Most of them (56%) had a moderate level of practice and adequate beliefs toward suction post coronary artery bypass graft. However, there was a statistically significant correlation between their level of practice and beliefs. Conclusions: Approximately all the studied nurses had a moderate level of practice in terms of ET suctioning with adequate level of beliefs, and mostly of them did not attend training courses toward endotracheal suction post coronary artery bypass graft at teaching hospital. Recommendations: An in-service trainer must conduct continuous training courses to improve nurses’ practice and enhance their beliefs toward Et suction. Cardiothoracic care nurses should be updated with nursing guidelines and oriented toward the use of advanced suction equipment and technique to promote the provided practice and their beliefs
Granulometry on classified images of sand grains

A novel automated approach to determine the size of previo usly classified images of sand grains is presented in this text. It is based on image analysis and pattern recognition techniques and consists of two main phases: first, the individual recognition of the grains and their classification into distinct mineralogical classes and second, the computation of a global granulometry of the sample, constructed from the individual mineralogical curves obtained by the application of morphological openings of increasing size. These imaging dimensional features are compared to the ones obtained by a sieving procedure of several sand samples collected along the Portuguese coast (river, dune and beach) whose high degree of similarity permits to validate the proposed approach.
Impact of Using Freeze-Shocked Adjunct Cultures on Edam Cheese Quality During Ripening

: Aiming to enhance the proteolysis of Edam cheese through using 1% freeze-shocked Lactobacillus (freezed for 96 hr/-18°C) on cheese curd based on the quantity of cheese-milk and followed its impact on the quality characteristics. Edam cheese was made with traditional starter to serve as control cheese. While other treatments were manufactured by using traditional starter, plus 1% freeze shocked of Lactobacillus casei (T 1 ), Lb. helveticus (T 2 ) or Lb. plantarum (T 3 ). The changes in the composition, ripening indices, rheological properties, and sensory attributes of Edam cheese from different treatments were followed during ripening period (60 days). Freeze-shocked treated cheeses had no significant effect on the gross composition with lower pH values as compared to control cheese. Also using freeze-shocked lactobacilli in Edam cheese enhanced all the ripening indices expressed as soluble nitrogen coefficient, non-protein nitrogen coefficient, free amino acids, and total volatile fatty acids. The rheological characteristics of Edam cheese with freeze-shocked cultures had lower hardness, cohesiveness, gumminess, and chewiness than control. Edam cheese made with Lb. helveticus (T 2 ), showed the highest proteolysis rate, while showing significantly lower hardness, gumminess, and improved sensory attributes than control cheese. Using freeze-shocked Lb. helveticus , Lb. casei and Lb. plantarum as adjunct culture for Edam cheese making had a pronounced effect on both flavor and body and texture of the resultant cheeses and reduced the ripening period to 45 days instead of 60 days for control cheese. Using 1% Lb. helveticus as adjunct culture on cheese curd improved the cheese quality more effectively
Emergence of Advanced Antifungal-Delivery Approaches for the Treatment of Tinea Pedis

A common fungal infection of the feet known as tinea pedis, which is also known as athlete's foot, significantly lowers quality of life. Its occurrence is caused by dermatophytes, a form of fungus that grows on the dead skin of the feet. Itching, scaling, redness, and skin breaking are among the symptoms that can be brought on by tinea pedis. In extreme circumstances, it may also result in nail infections and painful blisters. Antifungal medications, either systemic or topical, are widely used to treat tinea pedis. In recent years, there has been a surge in interest in developing novel medication delivery systems/strategies for the treatment of tinea pedis. By improving the drug's penetration into the skin and lowering the chance of systemic side effects, these systems seek to increase the safety and efficacy of antifungal therapy. This review has covered the many effective ways to treat tinea pedis, including traditional and state-of-the-art sophisticated delivery techniques. Furthermore, prospective avenues for treatment optimization and recurrence prevention of these severe fungal infections have been emphasized.
Emerging Horizons in the Diagnosis of Pancreatic Cancer: The Role of Circulating microRNAs as Early Detection Biomarkers for Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a poor prognosis, primarily due to a late diagnosis. Recent studies have focused on identifying non-invasive biomarkers for early detection, with microRNAs (miRNAs) emerging as promising candidates. This systematic review aims to evaluate the potential of circulating miRNAs as biomarkers for the early detection of PDAC, analyzing their diagnostic accuracy, specificity, and sensitivity. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search across PubMed, Embase, and the Cochrane Library was conducted. Studies published from January 2013 to October 2023 focusing on miRNA biomarkers for early PDAC detection were included. Data synthesis was performed through a narrative approach due to the heterogeneity of the studies. Nine studies met the inclusion criteria. Key findings include the elevated levels of specific miRNAs, such as miR-18a, miR-106a, and miR-25, in early-stage PDAC patients compared to controls. The integration of miRNA profiles with traditional biomarkers like CA19-9 showed improved diagnostic performance. However, challenges in the standardization of miRNA evaluation methodologies were noted. Circulating miRNAs demonstrate significant potential as non-invasive biomarkers for early PDAC detection. Despite promising results, further research and standardization are necessary for clinical application.
Treatment Cost Along With Pattern of Disease and Therapy in the Intensive Care Unit of a Tertiary Care Teaching Hospital in India

Background The intensive care unit (ICU) represents an important platform for conducting drug utilization analysis using defined daily dose (DDD)/100 bed-days and the financial burden of treatment as patients are seriously ill and are often suffering from chronic critical illnesses. Therefore, in this study, we evaluated the drug utilization patterns and cost of treatment in the ICU. Methods A retrospective observational analysis of the medical records obtained for the medical ICU of an apex tertiary care teaching hospital in central India was conducted for a period of three years from 2017 to 2019. All the patients admitted to the medical ICU during the study tenure were included in the study. Patients hospitalized in neonatal intensive care unit (NICU), pediatric intensive care unit (PICU), and surgical ICU were excluded from the study. The socio-demographic and clinical data, utilization of different classes of drugs, WHO-Anatomic Therapeutic Chemical (WHO-ATC) classification, DDD/100 bed days, hospital stay, etc. were analyzed. A partial pharmaco-economic analysis of the average cost of admission to patients was done. Results Data from 280 patients was assessed. The mean age was 47 ± 19.18 years and 58% were males. Antibiotics and injections were prescribed to 96% and 97.5% of the patients, respectively, during their ICU stay (median: seven days). Antimicrobial drugs were most frequently prescribed (n=1096, 68%); the most common were beta-lactams and carbapenems, followed by drugs acting on the central nervous system (5%) and cardiovascular system (4.3%). Cefoperazone/sulbactum, ceftriaxone, and piperacillin/tazobactam were the most utilized antibiotics with 8, 16, and 6 DDD/100 bed-days, respectively, while proton pump inhibitors, analgesics, and anti-epileptics were the most frequently prescribed non-antimicrobial drug class. The median cost of treatment per ICU admission was Indian Rupees (INR) 23,347 (IQR 12,552- 65,524). Conclusion Drug utilization assessment provides crucial information for understanding the usage of drugs in the settings of the ICU, and should be conducted regularly to help in the proper planning and implementation of rational drug use. Treatment costs reflect the high economic burden seen in ICU admissions.
Spontaneous Bleeding in Vestibular Schwannoma in Patients on Oral Anticoagulant Therapy: Report of Two Cases and Review of Literature.

OBJECTIVE Anticoagulant therapy is a risk factor for repeated intratumoral hemorrhage and acute enlargement of a vestibular schwannoma (VS) with neurological deficits. Therefore, we describe two cases of patients on oral anticoagulant therapy with intratumoral hemorrhage in which anticoagulant therapy prior to surgical resection was discontinued. We also discuss other similar cases from the literature since this is a rare event. CASE REPORTS We described the two cases of intratumoral hemorrhage in acoustic neurinoma and conducted a literature review of similar cases of patients with intratumoral hemorrhage in acoustic neurinoma who were also on oral anticoagulants. Both patients presented with CN-VII palsy prior to surgery; both also fully re-covered after surgery except for hearing loss on the tumor side. Our literature review found 50 cases of VS (reported as vestibular schwannomas in the literature) with intratumoral hemorrhage. From this total, 11 patients used oral anticoagulant therapy with reported poor outcomes and high mortality; 9 of these 11 cases were reported in the past 20 years. The incidence is expected to rise due to increased use of anticoagulant therapy due to onset of atrial fibrillation, atherosclerosis, and thromboembolism from longer human lifespan. CONCLUSION Anticoagulant therapy represents a risk factor for intratumoral hemorrhage and acute enlargement of VS tumor mass with neurological deficits.
Clonazepam as a Treatment of Excessive Infantile and Childhood Masturbation

Background: Masturbation is a self-stimulating pleasurable behavior of the child, which occurs between the ages of 3 months and 5 years. Clonazepam was recorded to reduce the frequency of sexual behavior during sleep. Objective: This study aimed to investigate the benefits of adding clonazepam to the general behavioral treatment of infantile and childhood masturbation. Patients and methods: This was randomized controlled trails (RCTs) conducted on a total number of 52 infants and pre-adolescent children with masturbation attending the Neurology Outpatient Clinic in Mansoura University Children Hospital (MUCH). Patients were classified into 2 groups: Group on behavioral therapy and clonazepam and group on behavioral therapy only. The response was observed in both groups as regards the frequency after treatment and duration till complete response Results: Masturbation was common among females, and cases with moderate socioeconomic level. Combined therapy was associated with a significant improvement in response compared to behavioral therapy only. Conclusion: Combined behavioral therapy and clonazepam is more effective and superior to behavioral therapy alone in ameliorating masturbation phenomena in infants and children.
The Scientology of Hypothesis Testing in Empirical Research: Emphasizing Economic Significance

Over the decades, scientists across various disciplines have cautioned against the practice of over-emphasizing statistical significance at the expense of economic or practical significance. It seems that empirical researchers in the 21st century have not heeded the caution because meeting statistical significance targets continue to take precedence over the wider discovery and publication of scientifically objective findings. Statistically insignificant results are rarely reported, in part due to publication bias towards statistically significant findings. The survey finds that although large sample sizes are widely used in empirical economics and finance research, none of the surveyed papers adopted alternative methods of hypothesis testing, such as Bayesian methods. All of them explicitly or implicitly used the classical Fisher’s hypothesis testing methods. This study finds that discussions on economic significance in nearly all papers (almost 97% of papers) only wrote one sentence or two regarding the magnitude of the effect of the regressors and a declaration that the findings were economically significant. We recommend that to enhance research credibility, other methods of hypothesis testing such as Bayesian methods, should be adopted. Journal article publishers should encourage the publication of statistically insignificant empirical findings. Economic or practical significance should be emphasized and comprehensively discussed.
Influence of Parent's Behavior and Practice on their Family Health

Numerous studies have demonstrated that parental conduct and practices have a direct impact on several elements of family life, including health. The goal of the study is to pinpoint the bad parenting practices that may have an impact on the social and physical development of their families. A pre-tested questionnaire was used to collect data for this descriptive-cross-sectional study, including 192 respondents and examined how parents' behaviors and practices affect the health of their families. Data were interpreted using the statistical package for social sciences, version 26. The results clarified the parents multifaceted impact on the health of their family. Regarding cognitive functioning, 85% of participants indicated that having supportive parents is essential for the growth of social and cognitive well-being in families. About 90% of participants agreed, in terms of conduct, that a parent's behavior can influence their family's behavior. On the social side, 50% of the participants agreed that there is a strong relationship between the absence of a parent and some effects on the social health of their families. The study made clear there is a strong correlation between parents' lack of literacy and their capacity to support their families, demonstrating that most participants believed that the presence of supportive parents is essential for the development of a family's mental and social health. Study suggests that in order to promote families' social and psychological well-being, supportive hospitals and specialized programs should be made available.
Comparative evaluation of nebulised dexmedetomidine vs fentanyl for the treatment of post-dural puncture headache (PDPH) in parturients after caesarean section under spinal anaesthesia: A randomised controlled study

Background and Aims: The incidence of post-dural puncture headache (PDPH) following spinal anaesthesia in the obstetric population is around 0.5%–2%. Hydration, bed rest, caffeine, paracetamol, non-steroid anti-inflammatory drugs, epidural blood patches, etc., are the various modalities used for its management. This study aims to compare nebulised dexmedetomidine versus fentanyl for the treatment of PDPH in parturients after caesarean section under spinal anaesthesia. Methods: Ninety obstetric patients aged 18–35 years with American Society of Anesthesiologists (ASA) physical status II/III and suffering from PDPH as per the criteria of the International Headache Society after caesarean section under spinal anaesthesia were recruited in this double-blinded randomised study. Patients were randomised to Group D (dexmedetomidine 1 µg/kg nebulisation), Group F (fentanyl 1 µg/kg nebulisation), and Group S (saline nebulisation 4mL). The nebulisation was done 12 hourly for 72 hours. Assessment parameters included pain score and the requirement of additional treatment such as paracetamol, caffeine, and epidural blood patch. Analysis of variance test was used for continuous quantitative variables, and the Kruskal–Wallis test was used for quantitative discrete data. Results: The pain scores at 1, 6, 12, 24, 48, and 72 hours following nebulisation were significantly lower in Group D in comparison to groups F and S (P < 0.001). The number of patients requiring additional analgesic therapy was lower in Group D in comparison to patients in other groups (P < 0.001). Conclusion: Dexmedetomidine nebulisation resulted in effective reduction in PDPH symptoms and pain scores. Nebulisation with fentanyl did not alleviate PDPH symptoms when compared to the control group.
Irrigation and Thermal Buffering Using Mathematical Modeling

Two methods of irrigation, drip, and sprinkler were studied to determine the response of the Javits green roof to irrigation. The control study was dry unirrigated plots. Drip irrigation consisted of irrigation tubes running through the green roof that would water the soil throughout and sprinkler irrigation used a sprinkler system to irrigate the green roof from above. In all cases, the irrigated roofs had increased the soil moisture, reduced temperatures of both the upper and lower surfaces, reduced growing medium temperatures and reduced air temperatures above the green roof relative to the unirrigated roof. The buffered temperature fluctuations were also studied via air conditioner energy consumption. There was a 28% reduction in air conditioner energy consumption and a 33% reduction in overall energy consumption between dry and irrigated plots. Values of thermal resistance or S were determined for accuracy and for this study, there was little change which is ideal. A series of infra-red and thermal probe measurements were used to determine temperatures in the air and sedum. It was determined that the sprinkler irrigation did a better job than the drip irrigation in keeping cooler temperatures within the green roof. A Mann-Whitney U test was performed to verify the variation in moisture temperatures buffering energy consumption. By getting a p-value < 0.05, it indicates that the model is accurate for prediction and medium temperatures were statistically different.
Antecedents and Consequences of Well-Being in the Business Sector in Saudi Arabia

The purpose of the study is to investigate antecedents and consequences of well-being. The study was conducted in the Saudi labour market in both the public and private sectors. A web-based questionnaire with 250 respondents was used to collect data for the study samples. SPSS and AMOS were used for statistical and path analysis, respectively. The study results clearly show that (1) there is a positive relationship between person-organization fit and well-being, (2) there is a strong correlation between person-organization fit and loyalty, (3) work-life balance has a significant positive relationship with well-being, (4) work-life balance is positively connected to employee loyalty, (5) work-life balance has a great effect on retention, (6) well-being has a positive relationship with loyalty, and, finally, (7) there is a relationship between loyalty and retention. These findings indicate that employee well-being may increase if workers feel they fit with their organizations and are provided with work-life balance programmes, which will ultimately lead to employee loyalty and increase employee retention in organizations. This research is distinct from prior investigations as it utilizes a model that has not been previously examined within the Saudi workplace. By assuring organizational support and implementing certain human resource management practices, the study provides managers with valuable suggestions on how to increase employee loyalty and well-being, which will ultimately lead to a higher retention rate. Thus, it has practical implications in human resource management and adds to the administrative literature on social exchange theory.
Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma

Renal cell carcinoma (RCC) accounts for the majority of cancer-related deaths worldwide. Overexpression of CD70 has been linked to advanced stages of RCC. Therefore, this study aims to develop a multiepitope vaccine targeting the overexpressed CD70 using immunoinformatics techniques. In this investigation, in silico multiepitope vaccines were constructed by linking specific CD70 protein epitopes for helper T lymphocytes and CD8+ T lymphocytes. To enhance immunogenicity, sequences of cell-penetrating peptide (CPP), penetratin (pAntp), along with the entire sequence of tumor necrosis factor-α (TNF-α), were attached to the N-terminal and C-terminal of the CD70 epitopes. Computational assessments were performed on these chimeric vaccines for antigenicity, allergenicity, peptide toxicity, population coverage, and physicochemical properties. Furthermore, refined 3D constructs were subjected to a range of analyses, encompassing structural B-cell epitope prediction and molecular docking. The chosen vaccine construct underwent diverse assessments such as molecular dynamics simulation, immune response simulation, and in silico cloning. All vaccines comprised antigenic, nontoxic, and nonallergenic epitopes, ensuring extensive global population coverage. The vaccine constructs demonstrated favorable physicochemical characteristics. The binding affinity of chimeric vaccines to the TNF receptor remained relatively stable, influenced by the alignment of vaccine components. Molecular docking and dynamics analyses predicted stable interactions between CD70-CPP-TNF and the TNF receptor, indicating potential efficacy. In silico codon optimization and cloning of the vaccine nucleic acid sequence were accomplished using the pET28a plasmid. Furthermore, this vaccine displayed the capacity to modulate humoral and cellular immune responses. Overall, the results suggest therapeutic potential for the chimeric CD70-CPP-TNF vaccine against RCC. However, validation through in vitro and in vivo experiments is necessary. This trial is registered with NCT04696731 and NCT04046445.