Miracle-dz/UniFAR-FTUs huggingface dataset:
Personalized Prophylaxis with myPKFiTCE: A Real-World Cost-Effectiveness Analysis in Haemophilia A Patients

Background and Objectives: This study aimed to assess the effectiveness and costs associated with pharmacokinetics-driven (PK) prophylaxis based on the myPKFiT® device in patients affected by hemophilia A (HA) in Italy. Materials and Methods: An observational retrospective study was conducted in three Italian hemophilia centers. All patients with moderate or severe HA, aged ≥ 18 years, capable of having PK estimated using the myPKFiT device, and who had had a clinical visit between 1 November 2019 and 31 March 2022 were included. Differences in clinical, treatment, health resources, and cost data were assessed comparing post-PK prophylaxis with pre-PK. The incremental cost-effectiveness ratio (ICER) was estimated as cost (EUR) per bleed avoided. Results: The study enrolled 13 patients with HA. The mean annual bleeding rate decreased by −1.45 (−63.80%, p = 0.0055) after the use of myPKFiT®. Overall, the consumption of FVIII IU increased by 1.73% during follow-up compared to the period prior the use of the myPKFiT. Prophylaxis based on the myPKFiT resulted in an ICER of EUR 5099.89 per bleed avoided. Conclusions: The results of our study support the idea that the use of PK data in clinical practice can be associated with an improvement in the management of patients, as well as clinical outcomes, with a reasonable increase in costs.
Predicting baccalaureate student result to prevent failure: a hybrid model approach

<div class="OutlineElement Ltr SCXW634036 BCX2" style="direction: ltr;"><p>The Moroccan Ministry of National Education has seen substantial modifications over the previous ten years, which have contributed to improving the quality of education. However, there is a discrepancy in the percentage of academic achievement between the regional directorates and educational institutions. Machine learning techniques have become a powerful tool for proactively predicting student admission. The goal of our paper is to build machine learning models using various algorithms to predict the final baccalaureate school year outcomes. We compare regression and classification to find the reasons behind students' failure and to choose an appropriate model for predicting the results. This helps decision-makers make appropriate interventions. </p></div>
Nuclear Cross-Section of Proton-Induced Reactions on Enriched 48Ti Targets for the Production of Theranostic 47Sc Radionuclide, 46cSc, 44mSc, 44gSc, 43Sc, and 48V

The cross-sections of the 48Ti(p,x)47Sc, 46cSc, 44mSc, 44gSc, 43Sc, and 48V nuclear reactions were measured from 18 to 70 MeV, with particular attention to 47Sc production. Enriched 48Ti powder was deposited on an aluminum backing and the obtained targets were characterized via elastic backscattering spectroscopy at the INFN-LNL. Targets were exposed to low-intensity proton irradiation using the stacked-foils technique at the ARRONAX facility. Activated samples were measured using γ-spectrometry; the results were compared with the data int he literature and the theoretical TALYS-based values. A regular trend in the new values obtained from the different irradiation runs was noted, as well as a good agreement with the literature data, for all the radionuclides of interest: 47Sc, 46cSc, 44mSc, 44gSc, 43Sc, and 48V. 47Sc production was also discussed, considering yield and radionuclidic purity, for different 47Sc production scenarios.
Polyamine contents in the spring wheat leaves and their relations to drought-resistance

The drought-resistant strain 504 had higher RWC than drought-sensitive strain 8139, and its Sod and Spm contents and activities of SOD and POD had stronger responses to drought than those of 8139; moreover, it had lower level of MDA. Thus, it can be concluded that Spd and Spm are more important than that of Put in plant response to drought stress, and that Spd and Spm probably play key roles in promoting the plant drought resistance.
Occupational and Environmental Asbestos Exposure and Survival of Patients with Asbestos-Related Cancer: A Follow-Up Study on Patients with Malignant Mesothelioma and Asbestos-Related Lung Cancer in Korea

Malignant mesothelioma and asbestos-related lung cancer are typically associated with a poor prognosis. However, it has been observed that some patients with these cancers survive significantly longer than the average survival period. While many preliminary studies have investigated factors influencing patient survival, the specific impact of asbestos exposure has not been thoroughly explored. We followed up with 546 patients with malignant mesothelioma and 902 patients with asbestos-related lung cancer, all identified as asbestos victims between 2009 and 2021. In both malignant mesothelioma and asbestos-related lung cancer, patients with occupational asbestos exposure exhibited not only shorter median survival times but also lower 3- and 5-year survival rates compared to those with environmental exposure. Additionally, a longer duration of occupational exposure and closer proximity to the source of asbestos were linked to shorter survival times and lower survival rates. Among the patients with occupational asbestos exposure, the highest hazard ratios (HRs) were observed in those who worked in the production of asbestos-containing products across both cancer types. In contrast, significant HRs were only noted in mesothelioma patients who lived near asbestos industries, slate houses, and redevelopment areas, within the environmentally exposed group.
Environmental regulation tools and corporate environmental information disclosure: Evidence from a-share-listed companies in Shenzhen and Shanghai, China

Environmental accounting is not only a more comprehensive and effective accounting model but also a more beneficial monitoring model for ecological protection and social development. Environmental accounting enables companies to develop economic benefits while protecting and managing the environment and to assume corresponding social responsibilities and obligations. Based on the importance of environmental regulation, this study attempts to evaluate the role of environmental regulatory tools in corporate environmental information disclosure using the Environmental Information Disclosure Index (EIDI) as a proxy variable. The regression analysis conducted on a panel dataset encompassing all A-share listed companies in the Shanghai and Shenzhen stock markets from 2007 to 2018 reveals a significant relationship between environmental regulatory tools and EIDI. Specifically, the Control command type, Public Participation Type, and Voluntary action-oriented Type have a positive and significant influence on corporate environmental information disclosure, whereas the Market Incentive Type has a negative and significant influence. This evidence suggests that the reasonable use of environmental regulatory tools is an important means of improving the quality of corporate environmental information disclosure.
Perspectives of employers on graduate employability skills: A case of Malaysia

One of the main reasons for the low employment rate of Malaysian graduates is a lack of skills. A substantial number of employers have expressed dissatisfaction with the quality of graduates, claiming that they lack the necessary skills required for successful employment. This research aims to investigate the perceptions of employers on the importance and level of satisfaction with the employability skills of graduates and subsequently examine the gap between them (level of importance and satisfaction). The survey included 63 employers from the manufacturing industry, and the data were analyzed. The results suggest that employers viewed all eight skills, such as English communication skills, thinking skills, positive attitude and teamwork, work planning skills, work discipline, self-motivation, and technology skills, as essential employability skills. However, the gap analysis reveals that they were dissatisfied with the skills possessed by the graduates, indicating that the skills of the graduates fell short of their expectations, which is consistent with their dissatisfaction. The highest differences between satisfaction and expectation arise from English communication skills and thinking skills, followed by self-motivation, a positive attitude, teamwork, work planning skills, technology skills, and work discipline skills. This study provides important insights for graduates, higher education institutions, and policymakers in Malaysia, as well as in countries facing the issue of the low employability of graduates.
Object Play as a Positive Emotional State Indicator for Farmed Spotted Paca (Cuniculus paca)

Simple Summary The spotted paca (Cuniculus paca) has been legally bred by small-scale producers in Brazil as an alternative source of protein. Although captive breeding of this species is considered relatively easy and promising for farmers, little is known about its welfare in captivity. Therefore, using boomer balls to induce object play, we investigated whether object play behavior can be used as a positive emotional state indicator for spotted pacas by examining whether it correlated with other pre-validated positive welfare markers, such as affiliative behavior and low amplitude bark vocalizations. As expected, we found that boomer balls stimulated play. At the same time, the spotted pacas showed more affiliative and exploratory behaviors, with decreased occurrence of agonistic interactions. We also found an increase in barking with low mean amplitude when the paca were provided with boomer balls. Object play behavior thus seems to be a promising non-invasive indicator of positive emotional state in this species because it was associated with an increase in low amplitude barks and more affiliative behavior. As object play can also improve welfare, stimulating its expression, through the provision of boomer balls, should be encouraged on spotted paca farms. Abstract We aimed to assess whether object play can be used as a positive emotional state indicator for farmed spotted pacas (Cuniculus paca) by examining its association with other positive welfare markers including affiliative behavior and low-amplitude vocalizations. We submitted six groups of spotted pacas (one male/two females per group) (N = 18) to an ABA experimental design (A1/A2: without ball; B: with three boomer balls). Object play behavior occurred only during phase B (mean = 35.5 s, SE = 6.4). The spotted pacas spent more time in affiliative and exploratory behaviors and less time engaging in agonistic interactions during phase B than in both control phases (A1 and A2) (p < 0.05). Moreover, the spotted pacas emitted more low-amplitude bark vocalizations during phase B than during either control phase (p < 0.05), and such vocalizations have previously been shown to indicate a positive affective state and low arousal level. Because the expression of object play was associated with a decrease in aggression, an increase in affiliative behavior, and an increase in low-amplitude barking, we suggest that object play can be used as a non-invasive indicator of positive emotional state in this species.
Parameter estimation of a model describing the human fingers

Abstract The goal of this paper is twofold: firstly, to provide a novel mathematical model that describes the kinematic chain of motion of the human fingers based on Lagrangian mechanics with four degrees of freedom and secondly, to estimate the model parameters using data from able‐bodied individuals. In the literature there are a variety of mathematical models that have been developed to describe the motion of the human finger. These models offer little to no information on the underlying mechanisms or corresponding equations of motion. Furthermore, these models do not provide information as to how they scale with different anthropometries. The data used here is generated using an experimental procedure that considers the free response motion of each finger segment with data captured via a motion capture system. The angular data collected are then filtered and fitted to a linear second‐order differential approximation of the equations of motion. The results of the study show that the free response motion of the segments is underdamped across flexion/extension and ad/abduction.
Comparison of Teachers’ and Social Pedagogues’ Ways of Handling School Bullying Incidents

The aim of the study was to compare the differences between teachers’ and social pedagogues’ ways of handling school bullying incidents. Quantitative descriptive research design was used and Estonian teachers (purposive sample, N=424) and social pedagogues (representative sample, N=177) completed the Handling Bullying Questionnaire (HBQ). The HBQ was used to measure how likely teachers and social pedagogues use five strategies (working with the bully, working with the victim, ignoring bullying, enlisting other adults, disciplining the bully) to handle school bullying incidents. Factor analysis and independent samples comparison revealed that teachers’ and social pedagogues’ strategies on responding to school bullying incidents differed on three of the five HBQ scale factor scores: (1) social pedagogues more often worked with the bully; (2) teachers more often ignored the bullying and (3) disciplined the bully. Teachers and social pedagogues used different strategies, whereas teachers tend to more ignore the bullying. This knowledge helps us to develop better bullying prevention and intervention to put emphasize on supporting teachers for using more effective strategies to collaboratively with non-teaching staff members deal with bullying in schools.
Outcomes Vary by Pre-Operative Physical Activity Levels in Total Knee Arthroplasty Patients

Physical activity (PA) is suggested to reduce osteoarthritis pain; however, it may be avoided by patients requiring arthroplasty. Our goal was to investigate objective and patient-reported outcomes as a function of pre-operative PA levels in patients undergoing total knee arthroplasty (TKA). A total of 1941 patients enrolled in a multicenter prospective cohort study investigating a smartphone-based care management platform for self-directed rehabilitation underwent TKA and were included in the analysis. Activity was categorized based on the cohort’s step count quartiles into low, moderate, and high pre-operative PA. Pre-operative and post-operative pain, EQ5D5L, KOOS JR, and step counts were compared by ANOVA according to activity group. Pre-operative pain scores increased with the decreasing activity level (all, p < 0.05) and were most improved post-operatively in the low PA group. High PA patients demonstrated the smallest improvements in EQ-5D-5L and KOOS JR. Low and moderate PA patients increased physical activity by three months, reaching 176% and 104% of pre-operative steps; high PA patients did not return to full step counts by one year post-operatively. Patients undergoing TKA who present with higher levels of physical activity report lower levels of pain and higher function pre-operatively but appreciate less improvement up to one year post-operatively. These results may be helpful in appropriate counseling of patient expectations before TKA.
PRODUCTIVITY IMPROVEMENT OF ONION (ALLIUM CEPA L.) UNDER AGRO- CLIMATIC CONDITIONS OF MANSEHRA, PAKISTAN

The present study was conducted to investigate the effect of various levels of NPK fertilizers on the yield and yield contributing factors of onion.Treatments includes namely T1(00-00-00),T2(25-25-12.5),T3(50-50-25),T4(75-75-37.5)and T5(100-100-50) NPK kg/ha. All P and K fertilizer was applied as basal dose while Nitrogen was applied in split doses. The variety used in the study was Swat-1. Data revealed that at harvest maximum plant height of 53.8cm, No. of leaves/plant (7), No. of roots/plant (95), No. of bulb/plot ( 221), fresh weight/bulb (127.7g), bulb size (6.4 cm), and yield of 24.92 tons/ha were recorded in treatment T5 provided 100-100-50 NPK kg/ha followed by plant height of 52.2cm, No. of leaves/plant (6), No. of roots/plant (83), No. of bulb/plot(156) , fresh weight/bulb 118g , bulb size 5.7cm, and 23.87 tons/ha yield in treatment receiving 75-57-37.5NPK kg/ha. The minimum plant height of 46.3 cm, No. of leaves/plant (5), No. of roots/plant (55), No. of bulb/plot (114), fresh weight/ bulb (103.5 g) bulb size (5.05cm) and yield of 17.80 tons/ha was recorded in control plot (without NPK). Results indicates that NPK @100-100-50 kg/ha proved to be the optimal dose of fertilizer to get maximum yield of onion.
Effects of Sowing Rates on Seedling Root Entwining and Seedling Quality of Machine-Transplanted Rice

To investigate the entwining effect of seedling roots and seedling quality of different sowing rates,using Zhongzheyou 1 and Yongyou 12 as the test materials,the effects of sowing rate on entwining effect of seedling roots,seedling quality,and seedling uniformity were studied with 6 levels of sowing rates. The results showed that increasing sowing rate could significantly improve the root entwining force,but the seedling quality decreased,the seedling was weak and the dry matter accumulation reduced. In addition,the seedling uniformity was poor,the proportion of weak seedlingse increased. The difference between the two varieties was significant. The quality of the seedlings of Zhongzheyou 1 decreased rapidly,and the percentage of weak seedlings increased quickly,while the sowing rate elasticity of Yongyou 12 was relatively larger. The seedling roots of Yongyou 12 entwined when the sowing rate reached 50 g each tray,and the seedlings in trays were tidy,the percentage of strong seedlings( Above 15 cm) was high. Although the seedling quality was good,the LAI was low,it means the seedlings in trays were few and scattered,so it was difficult for mechanized transplanting. The seedling roots entwined and the seedling quality was better when the sowing rate of Zhongzheyou 1 reached 50 g each tray,and the seedlings in trays were even and intense. In conclusion,taking everything into consideration,the optimum sowing rate of Yongyou 12 was 65 g each tray,while Zhongzheyou1 was 50 g each tray.
Impact of Treatment Related Side Effects in Quality of Life of Patients with Head and Neck Cancer

Cancer is the leading cause of death in all parts of the world. Head and neck cancer (HNC) comprises a unique group of aero-digestive tract malignancies that include the seventh most common cancer in the world. As patients receiving chemotherapy would usually experience many side effects and these can affect their quality of life captiously. So that this study can be used in amelioration of the Quality of life of patients with head and neck cancer. By understanding the quality of life status, therapy could be optimized accordingly or take precautionary measures to avoid that specific effect. A Cross-sectional study was carried out among 25 samples in the Department of Oncology, ESI PGIMSR, Rajajinagar of Bengaluru. The data was collected by using EORTC QLQ C 30 and HNC 35 questionnaires and responses were recorded. All information was processed and analyzed by using Microsoft Excel. The majority of the subjects included in the study were males (23, 92%) followed by females (8, 8%) The highest number of subjects included in the study belonged to the 50-59 years age group (9, 36%) followed by 60-69 age group (8, 32%). Out of 25 study subjects, 15 patients had social habits of smoking (37%) Alcohol consumption (15,39%), tobacco chewing (5,13%) and No habits (4,11%). The Quality-of-Life score obtained from the 25 study subjects who were undergoing any treatment was found to have a neutral to good quality of life (not excellent). The average raw score and the respective linear score were found to be 4.16,52.66 for global health status, the Functional scale was found to have 1.76,74.8 and the Symptom scale was found to be 1.88,29.29. The correlation was done in SPSS software and found a negative value which interpreted as the increasing Side Effects is leading to the decline in quality of life.
Effect of biofertilizers on the nitrogen economy of sugarcane in calciorthent

Field experiments were conducted on a calcareous alluvial sandy loam soil (calciorthent) to economise nitrogen in sugarcane with biofertilizers having Azotobacter and Azosoirillum alone or with chemical fertilizers. It significantly increased sugarcane and sugar yields as compared to nitrogenous fertilizers at 35 kg and 70 kg N/ha. Cane yields with 35 kg N/ha alongwith biofertilizers was at par in comparison with 70 kg N/ha alone indicate saving of nitrogenous fertilizer to the tune of 35 kg N/ha in sugarcane. Cane juice quality was not significantly affected with biofertilizers in experimental soil. Nitrogen is deficient in Indian soils and fertilizer nitrogen inputs give favourable sugarcane yield response. However 30 to 40 per cent and not very often more than 50 per cent of the fertilizer nitrogen input is utilised by any of the crop. Use of biofertilizers fortified by Azotobacter and Azospirillum have important role in utilisation of nitrogen input by sugarcane crop through higher biological nitrogen fixation and its increased availability and uptake of nitrogen(Wani, 1990). Here economy in nitrogen input in sugarcane through biofertilizers in calciorthent soils have been discussed.
Challenges of the Implementation of a Delirium Rate Scale in a Pediatric Intensive Care Unit: A Qualitative Approach

Introduction: Delirium in the pediatric population admitted to intensive care is a worrying reality due to its potential complications and the increase in associated costs. This study aims to explore the experiences of nursing staff of a Pediatric Intensive Care Unit after 15 months of starting a program to fight against childhood delirium in their unit. Methodology: A qualitative study was conducted through semi-structured interviews with Pediatric Intensive Care Unit (PICU) Key Informants. The Standards for Reporting Qualitative Research (SRQR) and the consolidated criteria for Reporting Qualitative Research (COREQ) were followed as quality measures for the study. Seven nurses (33% of the eligible population) from the PICU of a referral hospital were interviewed. Text transcripts were analyzed using the Interpretative Description and Qualitative Content Analysis method. Results: The interviewees indicated not identifying delirium as an important reality; with great deficiencies observed in what is related to the identification of delirium; identifying CAPD as an unreliable tool in their unit; and not sharing therapeutic objectives in this respect with the medical staff. Conclusions: The nursing staff presented a series of negative attitudes towards the phenomena of delirium in their unit, with gaps in training and in clinical management, and the diagnostic tool used, and did not see it as a priority objective of the unit, partly due to a resistance to change and a latent interprofessional communication conflict. A change at the formative, attitudinal, and relational levels is urgently needed for the success of the program and the well-being of the children in the unit.