Miracle-dz/UniFAR-FTUs huggingface dataset:
Additive effects of atezolizumab and bevacizumab plus chemotherapy for patients with non-small cell lung cancer regardless of presence of EGFR mutations, ALK rearrangements, or PD-L1 expression

The first-line treatment protocol for advanced non-small cell lung cancer (NSCLC) has improved with immune checkpoint inhibitor (ICI) development. The Food and Drug Administration (FDA) has approved three ICIs for second-line treatment of NSCLC (nivolumab, pembrolizumab, and atezolizumab), and randomized studies have shown superior overall survival (OS) with ICIs compared with second-line docetaxel (1-4).
Effect of hot callusing cable on graft success in walnut (Juglans regia) propagation: nursery results*

Walnut (Juglans regin L.) seedlings were whip and tongue grafted with scion of walnut cultivars and selections during 2001-2004. The graft unions were heated with hot callusing cable at 25°C. The differences in graft success between February (83.9%) and March (79.5%) were not significant. Genotype and quality of stock and scion highly affected the graft success. In the nursery conditions, the average graft take was 77.1%, and the range was between 62.5% and 88.7% for 21 genotypes.
Novel dissection approach of equine back muscles: new advances in anatomy and topography - and comparison to present literature

Novel dissection approach of equine back muscles: new advances in anatomy and topography - and comparison to present literature. Abstract Knowledge of the anatomy and topography of the equine back are essential for a correct diagnosis and treatment as well as communication among therapists, especially since different authors have not always agreed upon the anatomical topography of the epaxial back muscles. In this study, we performed a novel 3-D dissection procedure that focused on maintaining the integrity of the myofascial role in muscle topography. A total of 17 horses were carefully dissected, recorded and videotaped. The results revealed some interesting points. 1) The iliocostalis muscle (IL) was found to be clearly distinct from the longissimus dorsi muscle (LD) and positioned ventral to the lateral edge of LD. 2) Two distinct variations in the origin of the IL, i) from the Bogorozky tendon and the ventral epimysium of m. longissimus dorsi (LD) at the caudo-lateral region at L1 to L5, and ii) from the lumbar myofascia lateral to the lumbar transverse processes at the level of L2 to L4 have been found. 3)
Environmental control of seed germination in Arabidopsis thaliana: the role of GA and ABA signaling pathways

Seed germination is a drastic developmental transition taking the plant from a highly protected, desiccated and quiescent form of life (dry seed) into a more fragile, vegetative seedling. Seed germination is tightly controlled by the environment, which determines the relative levels of two phytohormones: GA (gibberellins) and ABA (abscisic acid). Consequently, GA and ABA are key regulators of Arabidopsis seed germination. GA stimulates germination and its synthesis upon seed imbibition is necessary for germination to take place. On the other hand, environmental conditions unfavorable for seed germination trigger ABA synthesis, which in turn arrests germination. Until now, metabolic and signaling pathways of these two hormones were studied separately. The purpose of my thesis was to re-examine the role of GA and ABA on the control of seed germination in order to understand how relative levels of these two hormones are coordinated within the seed.
A simple method for extracting the natural beauty of hair

A simple differential equation method is proposed for modeling the aesthetic features of human hair. In the method, a simplified cantilever beam simulation is employed for hairstyle modeling, which allows hairdressing variations with volumetric and realistic appearance. In order to describe the dynamical behavior of hair in an animation, one-dimensional projective differential equations of angular momenta for linked rigid sticks are also derived. For the problem of collision detection between hair and a human head, the “rough” approximate solution is provided, which gives visually satisfactory results by solving the projective equations under a ps~udo-force field. The hair’s pliability can be controlled by using a set of stiffness parameters in the method. In addition, a fast rendering technique for anisotropic reflection is introduced, which is derived from Blirm’s specular model. The efficiency of the proposed method is illustrated by the still images and short animations obtained.
Risk Factors for Gastrointestinal Injuries in Acute Coronary Syndrome Patients with Double Antiplatelet Therapy in One-Year Follow-Up

Background: The goal is to determine the incidence of symptomatic gastrointestinal (GI) injuries in acute coronary syndrome (ACS) patients receiving double antiplatelet therapy (DAPT). The risk factors for serious GI complications are also evaluated. Methods: 603 eligible patients from the Department of Cardiology at Zhongda Hospital between January 2014 and August 2015 were enrolled and the occurrence of GI injuries within one year assessed. The risk factors for serious GI complications were identified using cox regression analysis. Results: After one-year follow-up, 108 (17.9%) out of 603 patients developed symptomatic GI injuries: 22 (3.65%) with serious GI complications and 86 (14.2%) with GI symptoms. Drinking habit (95% CI: 1.512 - 8.796; P = 0.004) and previous peptic injury (95% CI: 2.307 - 18.080; P = 0.001) are independent predictors of serious GI complications, while proton pump inhibitor (PPI) was protective (95% CI: 0.120 - 0.699; P = 0.006) per cox regression analysis. Additionally, GI injuries of both serious GI complications and GI symptoms peaked in the first three months. Conclusions: Symptomatic GI injuries were relatively common in ACS patients with DAPT, especially in the first three months. Previous peptic injury and drinking habit were significant independent risk factors for serious GI complications, while PPI played a protective role in ACS with DAPT.
Heart Transplantation in the Era of the Left Ventricular Assist Devices

Orthotopic heart transplant is recognized as the gold standard for the treatment of end- stage heart disease. However, there is a perennial shortage of donor organs. Left ventricular assist devices (LVAD) represent a revolutionary tool for temporizing heart failure that is refractory to medical management until a suitable organ becomes available. This review highlights the LVAD as a tool for bridging to transplant. The history of the LVAD and its use in heart transplantation is described, as well as the current indications for use in the general heart transplant candidate as well as for selected subpopulations. It also highlights the major complications of LVAD use, advancements in the field, and selected current controversies related to the LVAD as bridge-to-transplant therapy.
Family emotional involvement in the adherence process to the treatment of the patient with heart failure in a peruvian public hospital

When people lose their health, they feel vulnerable and fragile, so the family's attitude during the disease process is crucial. The objective was to determine the relationship between family support and adherence to treatment in older adults diagnosed with congestive heart failure who go to the cardiology service at a National Hospital. The study was quantitative, correlational and cross-sectional. The population consisted of 65% female and 35% male both older adults diagnosed with CHF; two instruments were used: Family support and adherence to treatment were validated through expert judgment and a pilot test. The Spearman rho correlation coefficient (R=0.460) shows a significant correlation (p=0.000), which was positive and of medium level, which means that low levels of family support correspond to low levels of adherence, and vice versa. The family support variable obtained 70 % of medium level and 15 % correspond to high and low levels. Adherence to treatment reached 53% medium level while 22% high. In conclusion, family support and adherence to treatment are related to the emotional bonds that induce the patient to motivate his own self-care. Therefore, the family is key to encourage adherence and promote healthy behaviors in the patient. Likewise, nurses must educate the family on issues related to health care in a family context and the satisfaction of basic needs for the maintenance and quality of life of the patient.
Does Serum Adiponectin Levels Influence the Muscular Fitness in University Level Football Players

Adiponectin is known to be a recently debated hormone secreted from Adipose tissue. Many studies have revealed the varied effects of Adiponectin on obesity, type II diabetes mellitus, inflammation, cardiovascular disease and skeletal muscle etc., Not many studies have explored the connection between muscular fitness and Serum Adiponectin levels in the athletic population. The purpose of this study is to depict the connection between Serum Adiponectin levels and muscular fitness. We evaluated 29 male University level football players aged between 18 to 25 years. Anthropometric parameters like skin folds and girth measurements were taken. Overnight fasting 5ml venous blood sample was collected and analyzed to evaluate levels of Serum Adiponectin. Subjects then underwent muscular fitness tests such as Hand Grip Strength test, Broad Jump test and 1RM Leg Press test. Pearson correlation coefficient test was used to estimate the association of Serum Adiponectin levels with waist to hip ratio, muscle mass, hand grip strength, broad jump test score and 1RM leg press. Our results revealed a significant positive connection between levels of Serum Adiponectin and the muscular fitness parameters. A mild positive correlation between levels of Serum Adiponectin and Muscle mass was also observed. Thus Serum Adiponectin can be considered as one of the key determinants of Muscular Fitness in athletic population.
Experimental Procedure for Fifth Generation (5G) Electromagnetic Field (EMF) Measurement and Maximum Power Extrapolation for Human Exposure Assessment

The fifth generation (5G) technology has been conceived to cover multiple usage scenarios from enhanced mobile broadband to ultra-reliable low-latency communications (URLLC) to massive machine type communications. However, the implementation of this new technology is causing increasing concern over the possible impact on health and safety arising from exposure to electromagnetic field radiated by 5G systems, making imperative the development of accurate electromagnetic field (EMF) measurement techniques and protocols. Measurement techniques used to assess the compliance with EMF exposure limits are object to international regulation. The basic principle of the assessment is to measure the power received from a constant radio frequency source, typically a pilot signal, and to apply a proper extrapolation factor. This kind of approach is standardized for 2G, 3G, and 4G technologies, but is still under investigation for 5G technology. Indeed, the use of flexible numerologies and advanced Time Division Duplexing (TDD) and spatial multiplexing techniques, such as beam sweeping and Massive Multiple Input Multiple Output (MIMO), requires the definition of new procedures and protocols for EMF measurement of 5G signals. In this paper a procedure for an accurate estimation of the instant maximum power received from a 5G source is proposed. The extrapolation technique is based on the introduction of proper factors that take into account the effect of the TDD and of the sweep beam in the measured value of the 5G signal level. Preliminary experimental investigation, based on code domain measurement of appropriate broadcast channels, and carried out in a controlled environment are reported, confirming the effectiveness of the proposed approach.
Vitamin C supplementation as an adjunct to nonsurgical therapy in the treatment of chronic periodontitis: A clinical and biochemical study

Aim: The aim of the present study is to assess the effectiveness of Vitamin C supplementation, a known antioxidant, on periodontal health in patients with chronic periodontitis (CP) and salivary total antioxidant capacity (TAOC) levels. Materials and Methods: A sample of 50 patients diagnosed with CP and 50 healthy controls were selected for the present study. Fifty CP patients were further randomly divided into two groups. CP1 (25 patients received nonsurgical therapy alone) and CP2 (25 patients received Vitamin C supplementation (1500 mg/day) as an adjunct to nonsurgical therapy). Clinical parameters such as plaque index (PI) gingival index (GI), gingival bleeding index (GBI), pocket depth (PD), and clinical attachment level (CAL) were recorded at 1-month and 2-month post therapy. Salivary TAOC levels were measured by Koracevic's method at baseline and 2 months' post therapy. Results: Patients with CP showed lower salivary TAOC compared to control group (P < 0.001). There was a highly significant reduction in all the clinical parameters and salivary TAOC levels in CP1 and CP2 at 1-month and 2-month post therapy. CP2 group showed significant reduction in GBI score (P < 0.001) but failed to report any statistically significant improvement in PI, GI, PD, CAL, and in salivary TAOC levels compare CP1 group. Conclusion: Vitamin C supplementation showed significant reduction in GBI score at 1-month and 2-month post therapy but failed to show any additional benefit in reduction of PI, GI, PD, CAL, and in salivary TAOC levels compare to nonsurgical therapy. Further long-term investigation needs to be conducted to validate the results of the present study.
Current Status of Knowledge about and Attitudes Toward the Hepatitis B Virus at A Private University in Southern Vietnam: A Cross-sectional Self-reported Study

Context: Hepatitis B is a common infectious disease and can be life-threatening. The rate of hepatitis B virus (HBV) infection is increasing, especially in developing countries, including Vietnam. Aims: The aim of this study is to explore knowledge about and attitudes toward HBV among undergraduate students at a private university in southern Vietnam. Subjects and Methods: A cross-sectional self-reported study was carried out among 535 undergraduate pharmacy students between December 2017 and February 2018 at the Faculty of Pharmacy, Lac Hong University. All data analysis was performed using SPSS 20.0. Results: Out of 620 distributed questionnaires, 535 were returned - a response rate of 86.3%. Out of a total of 535 students surveyed, 174 (32.5%) were male and 361 (67.5%) were female pharmacy students. Overall, there was not a significant variance in knowledge between males and females regarding the knowledge about hepatitis B. However, the attitude score of females was higher than that of males, with a mean score of 3.37 ± 0.09 for males and 3.42 ± 0.14 for females. There was no difference in knowledge between males and females, but there was a difference in attitudes toward hepatitis B vaccination. Conclusions: The overall knowledge of pharmacy students showed satisfactory outcomes. However, it is necessary to improve attitudes about HBV vaccine by disseminating information to students and the public, especially by showing friends and family the relevant HBV information and conducting a health education campaign for people to help them adopt proper attitudes toward a self-care educational program.
Preliminary field survey on Mycobacterium bovis infection in cattle herds using caudal fold intradermal tuberculin test in two Northeastern States of Nigeria

Aim: A survey was conducted to determine the prevalence of bovine tuberculosis (bTB) in two states of Northeastern Nigeria, namely Bauchi and Gombe States, between February 2010 and November 2014 using caudal fold tuberculin (CFT) skin test. Materials and Methods: A total of 5489 cattle were screened using single CFT in Bauchi and Gombe States. Of the 5489 cattle, 2116 cattle were from 189 herds in five testing areas in Bauchi State and 3373 cattle in 217 herds from five testing areas from Gombe State. Results: On the basis of the CFT, herd prevalence obtained was 56.08% in Bauchi and 55.29% in Gombe State, while the individual animal prevalence was 10.96% in Bauchi and 13.73% obtained in Gombe State. The prevalence based on the testing areas in Bauchi State, Alamari had the highest prevalence with 19.4 % and Disina the lowest with 9.0 %, while in Gombe State, Wakaltu had the highest prevalence with 20.9 % and Poshereng the lowest with 8.0 %. Cows were more likely to have tuberculosis lesions than bulls (p=0.0035) in Bauchi State, but there was no significant difference in Gombe State (p=0.166). However, a statistically significant association (p<0.05) was observed among the cattle age groups with cattle ≥4 years having higher odds for tuberculin reactivity compared to those below the age of 4 years in Bauchi State only. Conclusion: There is the need to strengthen routine meat inspection and public health awareness programs on the zoonotic nature of bTB among the abattoir workers and the herdsmen.
Prognostic and clinicopathological roles of long non-coding RNA XIST in human cancers: a meta-analysis

Background: Mounting evidence has indicated that long non-coding RNA X-inactive specific transcript (XIST) could lead to cancer development and progression. This paper explored the association between XIST levels and clinical outcomes of cancer patients through a meta-analysis. Methods: We performed a systematic search through several databases, such as PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, and WanFang, in order to collect cohort studies that reported XIST expression in various cancers. Two investigators independently screened documents, extracted data and evaluated the risk of bias of the included studies. Results: Eventually, data from 841 patients were selected from 12 studies. Our results suggested that there was a significant correlation between high level of XIST and poor overall survival (HR =1.791, 95% CI: 1.030–3.114, P<0.001) or short recurrence-free survival (HR =2.188, 95% CI: 1.453–3.297, P<0.469) in cancers. Furthermore, the results indicated that high XIST expression tends to be closely related with larger tumor size (OR =1.456, 95% CI: 1.186–1.786; P<0.258), positive lymph node metastasis (OR =1.381, 95% CI: 1.148–1.662; P<0.252), and advanced TNM stage (OR =1.496, 95% CI: 1.285–1.741; P<0.088). Conclusions: High expression of XIST in cancer tissue is valuable as a predictor in the prognosis of cancers.
Translation resources and translator disempowerment

Language resources used for machine translation are created by human translators. These translators have legal rights with regard to copyright ownership of translated texts and databases of parallel bilingual texts, but may not be in a position to assert these rights due to employment practices widespread in the translation industry. This paper examines these employment practices in detail, and looks at the legal situation for ownership of translation resources. It also considers the situation from the standpoint of current owners of resources.
The presence of periopathogenic bacteria in subgingival and atherosclerotic plaques - An age related comparative analysis.

INTRODUCTION There is a known connection between periodontitis and atherosclerosis and the presence of periopathogens in blood vessels. However, changes of the oral microflora related to the aging process and its possible effects on atherosclerosis, have yet to be analyzed. The aim of this study was to assess temporal changes in the frequency of periodontal bacteria in the subgingival plaque and in atherosclerotic blood vessels of patients with atherosclerosis. METHODOLOGY The study included 100 patients with atherosclerosis and periodontitis, divided into two groups, below and over 60 years of age. Clinical examinations were performedand subgingival plaque specimens were collected as well as biopsy specimens from the following arteries: coronary (34), carotid (29), abdominal (10), femoral (10), mammary (13) and iliac (4). Subgingival and artery specimens were subjected to PCR detection of 5 major periodontal pathogens: Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythensis (Tf) and Treponema denticola (Td). RESULTS Tf was the most and Td the least frequent bacteria in both age groups and in both types of samples. The frequencies of bacteria in subgingival versus atherosclerotic samples were: Tf (76%:53%), Pi (71%:31%), Pg (60%:38%), Aa (39%:14%) and Td (21%:6%). Only Aa and Pi showed a significant difference of prevalence between younger and older patients. The most colonized artery was a. coronaria, followed by a. carotis, a. abdominalis, a. mammaria, and a. femoralis. CONCLUSIONS Patient's age and the distance of a given blood vessel from the oral cavity influenced microbiological findings in the atherotic plaque.
Effect of 29 weeks of periodized soccer training on the neuromuscular performance of soccer players under 20 years of age

Corrêa DA, Soares DS, Gonelli PRG, Cesar MC, Sindorf MAG, Crisp AH, Verlengia R, Balbino HF, Lopes CR. Effect of 29 Weeks of Periodized Soccer Training on the Neuromuscular Performance of Soccer Players Under 20 Years of Age. JEPonline 2016;19(4):3241. The purpose of this study was to investigate the effects of 29 weeks of periodized soccer training (linear during pre-season and ondulatory during the competitive period) on the neuromuscular performance of soccer players under 20 yrs of age. Ten regionally ranked male athletes (19.2 ± 1.3 yrs, body mass 71.1 ± 6.8 kg, height 179.0 ± 0.2 cm) participated in this study. The pre-season physical training program lasted 9 wks. The competitive period lasted 19 wks. The assessments were conducted at specific times during training periodization: baseline, 4, 8, and 19 wks. The results showed improvements in squat jump performance and maximal strength during the pre-season and the competitive period, respectively. On the other hand, repeated sprint ability and the 15-m sprint performance were reduced at the end of competitive period. Thus, the findings indicate that 29 wks of periodized soccer training increased the soccer players’ maximum strength and maintained their vertical jump performance. However, the models adopted did not improve repeated sprint ability and the 15-m sprint time.
The role of augmented reality in robotics

The purpose of this paper is to provide an insight into how augmented reality (AR) technologies are being applied to robotics. ,Following an introduction and a brief historical background to AR, this first provides examples of AR applications in robot programming. It then gives examples of recent research into AR-based robot teleoperation. Research activities involving the virtual fixtures (VF) technique are then discussed and finally, brief conclusions are drawn. ,Because AR concepts were first investigated in the 1990s, applications involving robotics have been widely studied. Programming with the aid of AR devices, such as the HoloLens headset, can be simplified and AR methods, including the VF technique, can improve the accuracy and speed of teleoperation, manipulation and positional control tasks. They can also provide visual or haptic feedback which leads to more intuitive operation and significantly reduces the cognitive load on the operator. ,This provides an insight into the growing role of AR in robotics by providing examples of recent research in a range of applications.