Miracle-dz/UniFAR-FTUs huggingface dataset:
DeepCoMP: Coordinated Multipoint Using Multi-Agent Deep Reinforcement Learning

—Macrodiversity is a key technique to increase the capacity of mobile networks. It can be realized using coordinated multipoint (CoMP), simultaneously connecting users to multiple overlapping cells. Selecting which users to serve by how many and which cells is NP-hard but needs to happen continuously in real time as users move and channel state changes. Existing approaches often require strict assumptions about or perfect knowledge of the underlying radio system, its resource allocation scheme, or user movements, none of which is readily available in practice. Instead,we propose three novel self-learning and self-adapting approaches using model-free deep reinforcement learning (DRL): DeepCoMP, DD-CoMP, and D3-CoMP. DeepCoMP leverages central observations and control of all users to select cells almost optimally. DD-CoMP and D3-CoMP use multi-agent DRL, which allows distributed, robust, and highly scalable coordination. All three approaches learn from experience and self-adapt to varying scenarios, reaching 2x higher Quality of Experience than other approaches. They have very few built-in assumptions and do not need prior system knowledge, making them more robust to change and better applicable in practice than existing approaches.
Microbiological Quality of Selected Non-Sterile Pharmaceutical Products Retailed in Anyigba, Kogi State, Nigeria

This study was designed to check for the microbiological quality of non-sterile products retailed in Anyigba. The use of contaminated non-sterile pharmaceutical products can cause hazards in a majority of ways like economic loss to the industrialists, alter the therapeutic effect of the drug and affect the health of a patient. A total of 10 samples were collected; the isolated organisms were characterized and identified by using morphological, cultural and biochemical tests. The organisms isolated were Staphylococcus aureus, E.coli and Pseudomonas spp, Aspergillus spp, Mucorspp, Saccharomyces spp and Rhizopus spp. The percentage of the isolate includes S. aureus 37 (45.7%), E.coli 16 (19.7%) Pseudomonas spp 28 (34.5%) to safeguard the product from contamination, it is important to ensure that good manufacturing practices such as raw material testing, equipment sanitization and automation, microbial testing of water, training of personnel, post marking surveillance, monitoring of environment among others were employed. The focus should also be on surveillance and effective monitoring of the distribution and marketing of pharmaceutical products. Local regulatory agencies such as the Standard Organization of Nigeria (SON), and the National Agency for Food,drug administration and Control (NAFDAC) should always ensure that all pharmaceuticals released into the market for sales and consumption should conform to specifications and are fit for their intended use.
Analysis of functional outcome following expert tibial nail fixation for distal tibial fractures

Background : Various treatment options exist for distal tibia fractures, such as external fixators, intramedullary nails, and internal plate fixation. Recently, there has been a growing inclination towards minimally invasive approaches with the expectation of better results. The objective of this study was to evaluate the efficacy of intramedullary nails, specifically elastic titanium nails (ETN), in the treatment of distal tibial metaphyseal fractures. Methods : A total of 30 patients with extra-articular distal tibial fractures, who sought treatment between March 2021 and March 2023, underwent intervention with ETN and were subsequently monitored for a minimum duration of 2 years. The functional outcomes were evaluated using the AOFAS score. Results : The patients had an average age of 46.6 years, with 18 males and 12 females. The right side was more commonly affected. Road traffic accidents (RTA) were the most frequent cause of injury. The average time for bone union was 19 weeks, ranging from 15 to 28 weeks. Two patients experienced complications related to malunion, while three cases had infections. However, despite these complications, all patients eventually achieved bone union. Conclusion: In conclusion, for distal tibial metaphyseal fractures without involvement of the articular surface, the utilization of intramedullary nailing with expert tibia nails provides satisfactory stability at the fracture site and contributes to expedited healing and earlier return to work.
Correlation between Inflammatory Systemic Biomarkers and Surgical Trauma in Elderly Patients with Hip Fractures

The treatment for hip fractures consists of a wide variety of orthopedic implants ranging from prosthesis to intramedullary nails. The purpose of this study is to determine the correlation between blood-count-derived biomarkers such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the monocyte-to-lymphocyte ratio (MLR) and the systemic immune-inflammation index (SII) and the level of aggression sustained by elderly patients during these surgical procedures. A total of 129 patients aged over 70 and diagnosed with acute hip fractures who underwent surgical treatment between November 2021 and February 2023 were included in our observational retrospective cohort study. Two groups were formed depending on the anatomic location of the fracture for statistical comparison: group 1 with extracapsular fractures, who received a closed reduction internal fixation (CRIF) with a gamma nail (GN) as treatment, and group 2 with intracapsular fractures, who received a bipolar hemiarthroplasty (BHA) as treatment. The length of hospital stay (LHS), duration of surgery, preoperative days, pre- and postoperative red blood count (RBC) and hemoglobin (HGB) levels and postoperative NLR, PLR and SII were significantly different between the two groups (p < 0.05). Furthermore, the multivariate analysis indicated that the postoperative NLR (p = 0.029), PLR (p = 0.009), SII (p = 0.001) and duration of surgery (p < 0.0001) were independently related to the invasiveness of the procedures. The ROC curve analysis demonstrated that a postoperative SII > 1564.74 is a more reliable predictor of surgical trauma in terms of specificity (58.1%) and sensitivity (56.7%). Postoperative SII as a biomarker appears to be closely correlated with surgical trauma sustained by an older population with hip fractures.
A Temperate Sinorhizobium Phage, AP-16-3, Closely Related to Phage 16-3: Mosaic Genome and Prophage Analysis

Soil Sinorhizobium phage AP-16-3, a strain phylogenetically close to Rhizobium phage 16-3, was isolated in a mountainous region of Dagestan, belonging to the origin of cultivated plants in the Caucasus, according to Vavilov N.I. The genome of phage AP-16-3 is 61 kbp in size and contains 62 ORFs, of which 42 ORFs have homologues in the genome of Rhizobium phage 16-3, which was studied in the 1960s–1980s. A search for Rhizobium phage 16-3-related sequences was performed in the genomes of modern strains of root nodule bacteria belonging to different species, genera, and families. A total of 43 prophages of interest were identified out of 437 prophages found in the genomes of 42 strains, of which 31 belonged to Sinorhizobium meliloti species. However, almost all of the mentioned prophages contained single ORFs, and only two prophages contained 51 and 39 ORFs homologous to phages related to 16-3. These prophages were detected in S. meliloti NV1.1. 1 and Rh. leguminosarum OyaliB strains belonging to different genera; however, the similarity level of these two prophages did not exceed 14.7%. Analysis of the orphan genes in these prophages showed that they encoded predominantly virion structural elements, but also enzymes and an extensive group of hypothetical proteins belonging to the L, S, and E regions of viral genes of phage 16-3. The data obtained indicate that temperate phages related to 16-3 had high infectivity against nodule bacteria and participated in intragenomic recombination events involving other phages, and in horizontal gene transfer between rhizobia of different genera. According to the data obtained, it is assumed that the repetitive lysogenic cycle of temperate bacteriophages promotes the dissolution of the phage genetic material in the host bacterial genome, and radical updating of phage and host bacterial genomes takes place.
ABO/Rh Blood Groups and the Temperament (Mizaj) Based on Traditional Persian Medicine Perspective: A Cross-sectional Study

Background: Mizaj is a fundamental concept in traditional Persian medicine (TPM) that explains the physiological and psychological traits of human beings. This study aimed to investigate the association between the ABO/Rh blood groups and the Mizaj.Materials and Methods: This cross-sectional study was conducted on 18-60 years old individuals who visited the Iranian Blood Transfusion Organization, Shiraz Branch. We used Mojahedi’s Mizaj questionnaire to determine the Mizaj of the participants. The participants’ blood group and Rh were determined based on the antibodies against types A, B, and Rh antigens of their blood. Results: We assessed 308 individuals consisting of 174 (56.49%) male and 134 (43.51%) female. The results of our study showed a significant relationship between the AB blood group and the cold Mizaj in both simple and compound Mizaj categories (P=0.012, P=0.014, respectively). Logistic regression analysis revealed that people with the AB blood group were 2.88 times more likely to have cold Mizaj than people with the O blood group (OR=2.88, 95% CI: 1.16 to 7.15). In addition, those with the A blood group were found to be 54% less likely to have a dry Mizaj than those with the O blood group (OR=0.46, 95% CI: 0.23 to 0.92). There was no significant association between the participants’ Mizaj and their Rh blood group (P>0.05). Conclusion: It seems that there was a significant relation between the AB blood group and cold Mizaj, as well as the A blood group and dry Mizaj. However, further studies are recommended with controlling the probable confounding factors.
Evaluation of Phenotypic Methods in the Clinical Isolates for Biofilm Detection of Staphylococcus aureus and Escherichia coli in Mukalla city, Hadhramout, Yemen

Introduction: Biofilms represent a complex structure comprising prokaryotic cells, proteins, sugars, and DNA as majorconstituents. Bacteria can grow in biofilms and associated with human infections and considered to be highly resistant toantibiotics. There are various methods to detect biofilm production like tissue culture plate (TCP), tube method (TM), andCongo red agar method (CRA). Objectives: This study aimed to compare three methods for the detection of biofilm formation in the clinical isolatesStaphylococcus aureus and Escherichia coli.Methods: A total of 60 clinical isolates of S. aureus and E. coli were subjected to biofilm detection methods by TM, CRAand TCP.Results: Out of the total 60 clinical isolates of S. aureus and E. coli, TCP method detected 33 (55%) as strong, 15 (25%)as moderate and 12 (20%) as weak/non-biofilm producers. The sensitivity of TM and CRA was 56.3% and 60.4%, and thespecificity was 58.3% and 66.7% respectively. In our validation of the diagnostic biofilm production tests, the TCP methodwas superior to TM and CRA methods for biofilm detection.Conclusion: The study concluded that the TCP method is accurate and reliable method for the detection of biofilmformation in the clinical isolates S. aureus and E. coli compared to TM and CRA methods, and can be recommended as ageneral screening method for the detection of biofilm producing bacteria in clinical laboratories.
PENGARUH KUALITAS PRODUK, HARGA, DAN CITRA MEREK TERHADAP KEPUTUSAN PEMBELIAN HONDA VARIO

This research is meant to find out the influence of product, price, and brand image both simultaneous and partial to the purchasing decision of Honda Vario at MPM Motor Sidoarjo. The sample collection technique has been done by using accidental sampling in which the sample collection is carried out by selecting the respondent who accidentally meets the researcher can be selected as sample, if the respondent is considered to be suitable as the data resources. The population of this research is using all the customers of Honda Vario which are located at MPM Motor Sidoarjo and the samples are 100 respondents. Meanwhile, the data analysis technique has been done by using multiple linear regressions method. The result of test shows that simultaneously product quality, price and brand image variables have positive and significant influence to the purchasing decision of Honda Vario at MPM Motor Sidoarjo. Meanwhile, based on the partial coefficient determination value of product quality variable has dominant influence to the customer decision. It occurs because Honda Vario has attractive product appearance, fuel efficiency and long durability product so these indicators are the criteria which affect the customers to make a purchasing decision on Honda Vario. Keywords: Product Quality, Price, Brand Image and Purchasing Decision.
Comparison of the Impacts of Benson Relaxation Technique and Foot Reflexology Massage on Sleep Quality of Patients with Systolic Heart Failure: A Randomized Clinical Trial

Background: Cardiovascular diseases can affect sleep quality. The use of non-pharmacological methods to improve the sleep quality of heart failure patients is essential. Therefore, this study compared the effects of the Benson relaxation technique and foot reflexology massage on sleep quality of those patients. Materials and Methods: In this clinical trial study, 93 patients with systolic heart failure referred to Javad Al-Aeme heart clinic in Torbat Heydarieh were selected with purposive sampling method and divided into the foot reflexology massage, Benson relaxation technique, and control groups using the balanced blocking randomization method. The Benson relaxation technique and the foot reflexology massage were performed for 20 and 30 minutes three days per week for four weeks, respectively. The control group only received routine care. Sleep quality was measured by the Pittsburgh sleep quality index and then compared among the groups before and after the intervention. The data were analyzed using ANOVA, Tukey's post hoc tests, paired t test, and Chi-square at the significant level of P < 0.05. Results: After interventions, the mean (SD) quality of sleep significantly increased in both intervention groups (Reflexology: pre-intervention 10.80 (3.40), post-intervention 6.60 (3.10), Benson relaxation: pre-intervention 15.50 (2.40) post-intervention 12 (2.60), compared to the control group (pre-intervention 10.50 (1.90) post-intervention 9.40(1.70) (p < 0.001). There was no significant difference between the two intervention groups (p = 0.53). Conclusions: The interventions improved the quality of sleep in patients with systolic heart failure. Therefore, these methods can be used as a suitable complementary treatment to improve the quality of sleep by nurses and midwives.
Application of natural killer immunotherapy in blood cancers and solid tumors

Purpose of review Natural killer (NK) cells are innate lymphoid cells characterized by their ability to attack aberrant and cancerous cells. In contrast to the activation of T-cells, NK cell activation is controlled by the interaction of NK cell receptors and their target cells in a manner independent of antigen organization. Due to NK cells’ broad array of activation cues, they have gained great attention as a potential therapeutic agent in cancer immunotherapy. Recent findings Ex vivo activation, expansion, and genetic modifications, such as the addition of a chimeric antigen receptor (CAR), will allow the next generation of NK cells to enhance cytotoxicity, promote survival, and create “off-the-shelf” products. In addition to these that are poised to greatly enhance their clinical activity, the inherent lack of potential for causing graft-versus-host disease (GVHD) and cytokine release syndrome (CRS) suggest that CAR NK cells have the potential to be complementary to CAR-T cells as a component of therapeutic strategies for cancer. Summary In this review, we will provide a general understanding of NK cell biology, CAR-NK cell advantages over CAR-T cell therapy, barriers to making NK cell immunotherapy viable, and current NK cell clinical trials for hematological malignancies and solid tumors. The next generation of NK cells has potential to change the circumstances guiding present cancer immunotherapies.
The Relationship of Egg Weight with DOC Weight and DOC Weight with Body Weight of First Generation of Sentul Chicken (G1)

This study aims to determine the relationship between egg weight and DOC weight and DOC weight with body weight of Sentul GI chickens at 1, 2, 3, and 4 months of age. The materials used were 78 males and 96 females of Sentul G1 chickens from the hatching of 315 G0 eggs. The research method is the experimental method. The variables of this study included: egg weight, body weight and body weight gain at DOC-4 months of age. Data analysis used t-test and correlation regression analysis. Egg weight had no significant effect (P≥0.05) on the sex of Sentul chicken DOC. The average body weight of male Sentul chickens was significantly (P <0.05) higher than that of female Sentul chickens. Egg weight had a significant effect (P<0.05) on DOC weight with a correlation value of 0.915 and 0.892. DOC weight had a significant effect (P<0.05) on body weight at the age of 1, 2, 3, and 4 months with the correlation values of Sentul roosters sequentially 0.892, 0.794, 0.757, 0.539 and Sentul hens correlation values sequentially 0.993, 0.859, 0.735 , 0.527. Conclusion: 1) Average egg weight, body weight, and body weight gain of male Sentul chickens were better than female Sentul chickens G1. 2) The relationship between egg weight and DOC weight and DOC weight at 1, 2, 3 and 4 months of age was positive.
Agency Costs, Executive Compensation, Bonding and Monitoring: A Stochastic Frontier Approach

This paper investigates the impact of various forms of bonding, firm monitoring, and executive compensation on agency costs. After relating market value for 1,043 firm-year observations to a number of standard covariates in a stochastic frontier framework, the resulting one-sided inefficiency term is interpreted as a proportional proxy for firm-specific agency costs. Following Battese and Coelli (1995) firm-specific agency costs are related to a variety of additional covariates including firm governance structures, firm liquidity, information asymmetry, and various forms of executive compensation. Consistent with agency theory, it is found that cash compensation tends to increase agency conflict while restricted stock incentives and executive stock options tend to lower it. Moreover, firms with high liquidity and low information asymmetry exhibit a lower degree of agency cost.
GSK-J4 Inhibition of KDM6B Histone Demethylase Blocks Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells by Modulating NF-κB Signaling

Multiple signaling pathways facilitate the survival and drug resistance of malignant B-cells by regulating their migration and adhesion to microenvironmental niches. NF-κB pathways are commonly dysregulated in mantle cell lymphoma (MCL), but the exact underlying mechanisms are not well understood. Here, using a co-culture model system, we show that the adhesion of MCL cells to stromal cells is associated with elevated levels of KDM6B histone demethylase mRNA in adherent cells. The inhibition of KDM6B activity, using either a selective inhibitor (GSK-J4) or siRNA-mediated knockdown, reduces MCL adhesion to stromal cells. We showed that KDM6B is required both for the removal of repressive chromatin marks (H3K27me3) at the promoter region of NF-κB encoding genes and for inducing the expression of NF-κB genes in adherent MCL cells. GSK-J4 reduced protein levels of the RELA NF-κB subunit and impaired its nuclear localization. We further demonstrated that some adhesion-induced target genes require both induced NF-κB and KDM6B activity for their induction (e.g., IL-10 cytokine gene), while others require induction of NF-κB but not KDM6B (e.g., CCR7 chemokine gene). In conclusion, KDM6B induces the NF-κB pathway at different levels in MCL, thereby facilitating MCL cell adhesion, survival, and drug resistance. KDM6B represents a novel potential therapeutic target for MCL.
Classroom management practices: Indonesian secondary schools teachers’ perceptions

The present study aims to investigate the Indonesian secondary school teachers' perspectives of practicing their classroom management to create a conducive classroom environment for learning. This research method is qualitative study, which is able to explore the perspectives of participants regarding their understanding and experience in managing classrooms to create conducive learning. The participants in this study were two teachers who taught in the urban and in rural area. After negotiating with the headmaster, the participants were recruited under a purposive sampling approach and gave their consent to participate in this study. In this study, data were collected through one-to-one interviews and analyzed using thematic analysis. Employing Garwood and Harris (2020) five parameters, two themes were resulted in each parameter. The participants were the teachers recognizing students' names and paying attention to their attitudes and intelligence. They also tried to have a good appearance, performance, and attitude as well as to make games. Regarding a consequence of breaking rules, the teacher in urban area applied academic punishments such as memorizing vocabularies; while, the one in rural area preferred to provide social punishments such as taking out the trash from classrooms. Furthermore, the teachers did not involve students in managing class rules, but made them individually or privately. Finally, both teachers informed class procedures in their teachings. The findings of this study implied that classroom management should be understood as well as practiced properly and appropriately as one of attempts the teacher could make to maintain and create a conducive learning atmosphere.
Standard Precautions: Knowledge and Practice among Nursing Students in UiTM

Standard Precautions are infection control practices to reduce the risk of acquiring the occupational infection when handling equipment and devices contaminated with any infectious. Nursing students were exposed early in hospitals environment and activities during their clinical attachment with an unknown infection status due to their lack of experience in performing a procedure. The purpose is to determine the knowledge and practice of Standard Precautions among nursing students in UiTM Puncak Alam. A cross-sectional design was used using Standard Precautions knowledge and practice questionnaire, then analyzed using SPSS version 21. The findings revealed that nursing students were having a good and moderate level of knowledge and practice towards the standard precautions. Further studies should be conducted to identify the factors contributing to the risk of transmission of microorganisms that may lead to occupational exposure infections during their clinical attachment.
Statistica Sinica Preprint No: SS-2020-0118

Estimation Conditional Random Abstract: We propose a novel methodology based on a Bayesian Gaussian conditional random ﬁeld model for elegantly learning conditional dependence structures among multiple outcomes, and between the outcomes and a set of covariates simultaneously. Our approach is based on a Bayesian hierarchical model using a spike and slab Lasso prior. We investigate the corresponding maximum a posterior (MAP) estimator that requires dealing with a non-convex optimization problem. In spite of the non-convexity, we establish statistical accuracy for all points in the high posterior region including the MAP estimator and propose an eﬃcient EM algorithm for computation. Through simulation studies and a real application, we demonstrate the competitive performance of our method for the purpose of learning the dependence structure.