Miracle-dz/UniFAR-FTUs huggingface dataset:
ABCA1 is associated with the development of acquired chemotherapy resistance and predicts poor ovarian cancer outcome

Aim: This study investigated the ATP binding cassette (ABC) transporter (ABCA1, ABCB1, ABCB3, ABCC2 and ABCG2) expression in high grade serous ovarian cancer (HGSOC) tissues, cell lines and primary cells to determine their potential relationship with acquired chemotherapy resistance and patient outcome. Methods: ABC transporter mRNA and protein expression (ABCA1, ABCB1, ABCB3, ABCC2 and ABCG2) was assessed in publicly available datasets and in a tissue microarray (TMA) cohort of HGSOC at diagnosis, respectively. ABC transporter mRNA expression was also assessed in chemosensitive ovarian cancer cell lines (OVCAR-5 and CaOV3) versus matching cell lines with acquired carboplatin resistance and in primary HGSOC cells from patients with chemosensitive disease at diagnosis (n = 10) as well as patients with acquired chemotherapy resistance at relapse (n = 6). The effects of the ABCA1 inhibitor apabetalone in carboplatin-sensitive and -resistant cell lines were also investigated. Results: High ABCA1 mRNA and protein expression was found to be significantly associated with poor patient outcome. ABCA1 mRNA and protein levels were significantly increased in ovarian cancer cell lines (OVCAR-5 CBPR and CaOV3 CBPR) with acquired carboplatin resistance. ABCA1 mRNA was significantly increased in primary HGSOC cells obtained from patients with acquired chemotherapy resistance. Apabetalone treatment reduced ABCA1 protein expression and increased the sensitivity of both parental and carboplatin-resistant ovarian cancer cells to carboplatin. Conclusion: These results suggest that inhibiting ABCA1 transporter may be useful in overcoming acquired chemotherapy resistance and improving outcome for patients with HGSOC.
Optimization of cultural conditions of gellan gum production from recombinant Sphingomonas paucimobilis ATCC 31461 and its characterization

Microorganisms that produce exopolysaccharides have currently gained broad attention and are a subject of great concern for modern-day biotechnologists and microbiologists. Sphingomonas paucimobilis is a Gram-negative rod-shaped bacterium isolated from the Elodea plant tissue. The effect of the culture conditions on gellan gum production by recombinant S. paucimobilis ATCC 31461 in a stirred-type bioreactor was investigated. The products of fermentation were characterized by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The FTIR spectrum revealed characteristic peaks of different functional groups in the gellan. SEM was carried out to observe the morphology of the gellan gum, while the thermal stability of the biopolymer was determined by TGA and DSC analysis. The compositional analysis of the purified gellan showed that it is a heteropolymer containing glucose, rhamnose, and glucuronic acid. The compression test of the gellan revealed its textural property. Maximum gellan gum was attained after 48 h of incubation at 30°C with a pH of 6.5, 500 rpm, and 100% dissolved oxygen. The rheology study indicated the non-newtonian nature of gellan gum. The solubility of gellan gum in different polar and non-polar solvents was also investigated. The findings in this study showed that gellan gum produced by recombinant S. paucimobilis ATCC 31461 has a high potential to be utilized in the pharmaceutical and food industry.
KIDNAPPING MENACE: CAUSES AND EFFECTS ON HOTEL BUSINESSES IN GHANA

The purpose of the study was to ascertain the influence of kidnapping on hotel business in Ghana. The study adopted survey design covering a cluster sample of 60 managerial staffs drawn from 5, 4 and 3star hotels across major cities in the country. Questionnaire was the main data collection instrument and data analysed through descriptive statistics. The study identified unemployment, poverty, greed, politics, illiteracy, rituals and spiritual proclivity as major causes of kidnapping in the country. The study further revealed influence of kidnappings on hotel businesses as: reduction in guest patronage, decreases in profitability, increases in expenditures on security and high level of mistrust among staff. Finally, the study showed that training anti-kidnapping agencies, heavy punishments for offenders, job creation, and education were possible solutions to the menace of kidnapping in Ghana. It is, therefore, recommended that efforts be made by government to create more job avenues to tackle the problem of unemployment and create public awareness of the citizen’s safety and security. It is envisaged that the study would be beneficial to the government, practitioners of hospitality and tourism industry, hospitality and tourism educators and security agencies.
Board of Directors, Audit Committee, Executive Compensation and Tax Avoidance of Banking Companies in Indonesia

Tax avoidance is the hottest issue in the last five years. It is reinforced with the Tax Amnesty Program by the Directorate General of Taxation (DJP), which began in June 2016. Therefore, this study aims to obtain empirical evidence of the influence of good corporate governance and executive compensation on corporate tax avoidance. This study used 215 banking companies listed on the Indonesia Stock Exchange (IDX) for 2014-2018. This study using a purposive sampling method that produced 119 suitable samples. The analytical method used is multiple linear regression analysis through IBM SPSS Statistics 25 software. Computation of tax avoidance is proxied by computing of Effective Tax Rates (ETR). Good corporate governance is proxied by the size of the board of directors and the audit committee, and executive compensation is proxied by all director compensations. The size of the audit committee is a total of the audit committee in one period. The size of the board of directors is the total of the board committee in one period. This study used ROA and Leverage as a control variable. In this study, it was found that executive compensation and good corporate governance, which was proxied by the Size of the board of directors and the Size of the audit committee shown a positive effect on tax avoidance. Investors who do not want tax avoidance must pay attention to executive compensation and good corporate governance in the company. In contrast, control variables have not significant effect on tax avoidance.
Biofertlizer Lumbrical improves the growth and ex vitro acclimatization of micropropagated pear plants

In vitro micropropagation of plants is highly useful for obtaining large quantities of planting material with valuable economic qualities. However, plantlets grow in vitro in a specific environment and the adaptation after the transfer to ex vitro conditions is difficult. Therefore, the acclimatization is a key step, which mostly determines the success of micropropagation. The aim of this investigation was to study the effect of the biofertlizer Lumbrical on ex vitro acclimatization of micropropagated pear rootstock OHF 333 (Pyrus communis L.). Micropropagated and rooted plantlets were potted in peat and perlite (2:1) mixture with or without Lumbrical. They were grown in a growth chamber at a temperature of 22±2 °C and photoperiod of 16/8 hours supplied by cool-white fluorescent lamps (150 μmol m-2 s-1 Photosynthetic Photon Flux Density, PPFD). The plants were covered with transparent foil to maintain the high humidity, and ten days later, the humidity was gradually decreased. Biometric parameters, anatomic-morphological analyses, net photosynthetic rate and chlorophyll a fluorescence (JIP test) were measured 21 days after transplanting the plants to ex vitro conditions. The obtained results showed that the plants, acclimatized ex vitro in the substrate with Lumbrical, presented better growth (stem length, number of leaves, leaf area and fresh mass) and photosynthetic characteristics as compared to the control plants. This biostimulator could also be used to improve acclimatization in other woody species.
Review of studies on motor-manual felling productivity in eucalypt stands

Globally, about 20 million ha of land area is occupied by plantations of Eucalyptus. Motor-manual tree harvesting techniques (using chainsaws) are still applied in eucalypt plantations, especially in difficult terrains or for largesized trees where mechanised felling may not be an effective and safe possible option to apply. There is little information available on motor-manual felling in eucalypt stands. This article reviewed available literature on the productivity of motor-manual felling. The results were classified into four regions, including Africa, Asia/ Oceania, America and Europe. Results of international studies indicate that the main factors impacting the productivity of motor-manual felling include diameter at the breast height (DBH), travelling distance to trees, understory density and terrain slope. Operator experience also plays a key role in felling operations. The range of reported productivity varied from 0.6 m/PMH0 to 48.9 m /PMH0 in different regions. This article provides key recommendations on improving motor-manual felling productivity, which can provide a guide for sustainable harvesting planning purposes.
Impact of pre-harvest treatments on guava fruits under ambient storage conditions

Current research investigation entitled “Impact of pre-harvest treatments on fruit traits stored under ambient conditions in winter guava cv. Allahabad Safeda” was conducted on 7-year-old trees in the Malwa region of Punjab in collaboration with Department of Horticulture, School of Agriculture, Lovely Professional University, Phagwara. The experiment was designed to retain marketability and minimization of quality deterioration by treating the fruits with certain chemicals. The fruits were treated with NAA and salicylic acid each at 100, 200, 300 ppm and ascorbic acid at 75,150 and 300 ppm. Treated fruits were kept at ambient conditions (during Dec.-Jan.) and tested for quality characters after 3, 6, and 9 days of storage. It can be concluded from present research studies that foliar application of NAA 100 ppm was proved to be the best treatment concerning fruit breadth (5.98 cm) and weight (185.28 g) while the highest palatability (18.94 out of 20) was retained by NAA 200 ppm. Improvement in color development along with maximum fruit firmness (15.11 lbs/cm2) was achieved with SA 200 ppm treatment. KeywordsGuava, Pre-harvest, Chemicals, Ambient storage, Quality
digestibility, carcass characteristics, and gastric health in growing-finishing

27 Objective: This study was conducted to evaluate the effects of feed processing and particle size on 28 growth performance, nutrient digestibility, carcass characteristics, and gastric health in growing29 finishing pigs. 30 Methods: A total of 360 growing pigs [(Yorkshire × Landrace) × Duroc; [22.64 ± 0.014 kg initial 31 body weight (BW)] were allocated to 1 of 6 treatments with 6 replicates by body weightBW and sex, 32 and 10 pigs were housed in one pen in a randomized complete block design (RCBD). Body 33 weightBW and feed intake were recorded to calculate the average daily gain (ADG), average daily 34 feed intake (ADFI) and gain-to-feed ratio (G/F ratio)growth performance. For the digestibility trial, a 35 total of 24 barrows with an initial BW of 33.65 ± 0.372 kg were split into 6 treatments with a 36 completely randomized design. Dietary treatments were designed by a 2 x 3 factorial arrangement of 37 treatments based on two main factors, particle size (600, 750, 900 μm) and feed form (mash and pellet) 38 of diet. Experimental diets were corn-soy bean meal-based diets and formulatedformulated to contain 39 the requirements of the NRC (2012). 40 Results: BW and ADG average daily gain were not changed by dietary treatments, and the feed 41 intake of finishing pigs (wks 6-12) was increased when the pigs were fed a mash diet (P<0.05). For 42 the overall period, the feed efficiency of pigs was improved with the pellet diet (P<0.01) and reduced 43 particle size (P<0.05). The pellet diet had effects on increasing crude crude fat digestibility (P<0.01) 44 relative to a mash diet, but there was no considerable change in dry matterDM and crude proteincrude 45 protein digestibilities by dietary treatments. In the evaluation of gastric health, a trend for an increased 46 incidence of keratinization in the esophageal region was observed as particle size decreased (P=0.07). 47 Conclusion: Feed efficiency could be improved by pellet diet and reduced particle size. Nutrient 48 digestibility, carcass characteristics, and gastric health were not affected by feed form, and particle 49 size ranged from 600 to 900 μm. 50 51
FINE NEEDLE ASPIRATION CYTOLOGY AS A DIAGNOSTIC TOOL; AN ASSESSMENT

The study is about breast lesions which is a common cause of mortality and morbidity among females. To avoid negative consequences, there is need for urgent diagnosis and treatment. Fine Needle Aspiration Cytology (FNAC) is a useful diagnostic tool and possess higher level of accuracy. In this study, the objective was to determine the accuracy of FNAC in diagnosis of palpable breast lumps. Additionally, the objective was to find the correlation between cytological findings and histopathological examination of surgical specimens. The methodology of the study was based on retrospective study method. FNAC of breast lump was conducted on 271 patients out of which 104 formed the base group. The results showed that there were 104 patients of base study who had average age of 32 years. There were 54 patients with lump in left breasts, and 46 patients with lump in right breasts and 4 patient had bilateral lump. There were 77 patients with benign, 34 patients with malignant, and 3 had atypica;/suspicious lesions on cytological examination. Based on histopathological examination, 77 cases were related to benign, 26 were related to malignant, and 1 with atypical/suspicious. Cyto-histological concurrence was 93.05% and 79.2% for Fibroadenoma and Infiltrating ductal carcinoma respectively. Overall sensitivity of FNAC procedure was 94.17%, specificity 100% and accuracy 93.26%. On the basis of result, OPEN ACCESS International Medical Science Research Journal Vol. 1(2), pp. 32-44, September, 2019 Fair East Publishers Journal Homepage: www.fepbl. com/index.php/imsrj
Effect of Rosemary Extract and Vitamin E on Lipid Peroxidation and the Quality During Chilling and Frozen Storage of Fried Nile Tilapia Fillets (Oreochromis niloticus)

Antioxidants are added to fresh and processed meat to prevent lipid oxidation, retard development of off-flavors, and improve color stability. Synthetic antioxidants have been confirmed for their toxicological and carcinogenic effects. Thus, the food industry now chooses natural products over synthetic ones. This study was carried out to investigate the effect of Rosemary extract (R.E.) and vitamin E on the quality of fried fillets of Nile tilapia (Oreochromis niloticus) during chilling and frozen storage. Fillets of Nile tilapia were treated with (R.E.) 0.1%, 0.2%, 0.3% and Vitamin E 0.1% then stored for 5,10 and 15 days at 4±1°C and for three months at -18±2°C. Then chemical tests including Peroxide value (PV), Thio-barbituric acid (TBA), Tri-methylamine-nitrogen (TMA-N) and Total volatile base-nitrogen (TVB-N) were done to evaluate the preservative effect of (R.E.) and vitamin E during storage. The TBA and PV increased in all treatments due to lipid peroxidation. Results showed that TMA-N,TVB-N, value of (R.E.) and vitamin E treated samples were significantly lower than those of the control samples (P<0.05). Results of our investigation revealed that R.E. retarded oxidative changes in chilling and frozen fried fillets of Nile tilapia whereas R.E. 0.1%, 0.2% and vitamin E 0.1% were not as effective as R.E. 0.3% on oxidative stability. Best oxidation inhabitation results on chilling and frozen fried fillets of Nile tilapia was obtained when employing of R.E. The obtained results also showed that there was a significant (p<0.05) enhancement in sensory quality attributes of fried fillets of Nile tilapia; samples treated with R.E. and vitamin E. Conclusion, The tested R.E. had a high effectiveness as antioxidative and antimicrobial should be utilized for extending the shelf-life through retarded the spoilage and enhancing quality attributes of fried fillets of Nile tilapia during chilling and frozen storage.
Ethanolic Extract of Capparis decidua Fruit Ameliorates Methotrexate-Induced Hepatotoxicity by Activating Nrf2/HO-1 and PPARγ Mediated Pathways

Introduction: Methotrexate, a folate antimetabolite, immunosuppressant and cytotoxic chemotherapeutic agents employed for malignant conditions. Continuous exposure of methotrexate produces adverse side effects especially liver toxicity. Recently, medicinal plants are gaining an importance owing to their phytoconstituents which are responsible for their medicinal value. Capparis decidua is one such medicinal plant widely used in the traditional system of medicine. No study has focused the mechanism of hepatoprotective property of Capparis decidua via Nrf2/HO-1 and PPARγ signaling pathway. Hence the study was mainly focused on its ability to modulate Nrf2 and PPARγ signaling in the methotrexate induced hepatotoxicity in Wistar rats. Materials and Methods: 30 female Wistar albino rats were divided into five groups. Following a single dose of methotrexate (20 mg/kg, intraperitoneally) injection, Wistar rats were orally administered with Capparis decidua at a doses of 250 mg/kg and 500mg/kg for 14 days. AST, ALT and ALP, antioxidants like GST, GPx, GR, were assessed in hepatic tissue. LPO, H2O2, OH radicals were assessed. mRNA expression of Nrf2, HO-1, PPARү was carried using real-time PCR in hepatic tissue. Nrf2, TNF-α, IL -1β proteins were assessed using western blot. Results: Methotrexate administration significantly increased liver function marker, caused lipid peroxidation and decreased antioxidants levels. Treatment with Capparis decidua caused significant decrease in AST, ALT, ALP, levels and significant increase in GST, GPx, GR. Methotrexate decreased mRNA expression of Nrf2, HO-1, PPARγ. Capparis decidua prevented methotrexate induced liver injury by upregulating Nrf2 and PPARү signaling pathway. Capparis decidua also suppressed inflammatory markers like TNF-α and IL -1β proteins. Conclusion: Capparis decidua has thus attenuated methotrexate induced hepatotoxicity and this could be via up-regulation of Nrf2/HO-1 and PPARγ pathways.
The Effect of Customer Uncivil Behavior on Counterproductive Work Behavior and Quit Intention of Airlines’ Frontline Employees: Emotional Intelligence as a Moderator

The main philosophy of most service-oriented organizations is „the customer is always right‟. Organizational regulations ask employees to delight customer even in cases including customer uncivil behaviors, which in turn pay employees to show negative work outcomes. This research aims to examine the relationships between customer incivility, counterproductive work behavior (CWB) (e.g., verbal and physical abuse, withdrawal behaviors and production deviance) and intention to quit of frontline employees in airline industry. Furthermore, the moderating effect of emotional intelligence (EI) in the previous relationships is also examined. Using a structured questionnaire, a randomly sample of frontline employees working in airlines were invited to participate in this research. A total of 406 questionnaires were analyzed using smart PLS 3.21 for regression-based Partial Least Squares Structural Equation Modeling (PLS-SEM). The results revealed that customer incivility positively affects (CWB) and quitting intention of Egyptian frontline employees in airline industry. Moreover, it was found that emotional intelligence moderates the relationship between customer incivility and CWB. In addition, EI was also emerged as a moderator among customer incivility and intention to quit. Implications of the findings and directions for future research are discussed.
Employees ’ Performance in MTN Nigeria , Plc

Emails: ishola.genty@lasu.edu. ng, abioroma@funaab.edu. ng DOI: 10.36108/ljerhrm/0202.02. 0131 Abstract This study examines the relationship between job crafting (task crafting and relational crafting) and employees' performance (employees’ task performance and organizational citizen behaviour) amongst staff of MTN Nigeria Plc. This research makes use of a survey design and analysis was based on primary data generated through a structured questionnaire. Two research hypotheses were formulated and tested at 0.05 level of significance. The findings revealed that there was a statistically significant influence of task crafting on employees’ task performance in MTN Nigeria, Plc (R 2 = .088, F = 17.844, p < 0.050). Similarly, there is a significant positive relationship between relational crafting and organizational citizen behaviour ( rp=0.331, n=187, p < 0.050). From the study, it was concluded that workers require a high degree of autonomy and independence on their jobs to perform more efficiently and effectively in order to improve their performance. It was recommended amongst others that organization should provide a flexible job design and structure as well as interpersonal relationship for its employees’ so as to enable them to better perform on the task and create organizational citizen behavior among the employees.
Intraperitoneal Lavage with Bupivacaine 0.2% and Post-operative Pain in Laparoscopic Colorectal Surgery: A Prospective, Double-Blind, Randomized Controlled Trial

Background: Local anesthetics have been proven as a method to reduce postoperative pain and opioid use. It reduces side effects associated with drug use and may improve patient health and reduce hospital length of stay. The aim of this study was to evaluate the effect of intraperitoneal bupivacaine on post-operative pain in laparoscopic colorectal surgery. Methods: In this prospective randomized control trial, 63 patients aged 20-70 years candidates for laparoscopic proctectomy or rectopexy surgery, were divided into two groups. In the case group, anastomosis site was washed with 50 mL of bupivacaine 0.2% intraperitoneally. In the control group, equal volume of normal saline was used as placebo. Intravenous autofuser pain control filled with 3 g paracetamol was considered for all patients. Visual analogue scale (VAS) was recorded at 2, 8, 24 hours and narcotic usage was recorded totally for the first 24 hours after the operation. Results: There was no significant difference between pain scores according to the VAS criteria at 2, 8, and 24 hours after the operation in the case and control groups (P>0.05). Total pethidine consumption during the first 24 hours after the operation was lower in the bupivacaine group (49.03 ± 45.77) compared to the control group (77.74 ± 63.50), but the difference was not significant (P>0.05). However, the total dose of pethidine used after 24 hours after proctectomy (not rectopexy) was significantly lower in the bupivacaine group than that in the control group (P<0.05). Conclusion: Intraperitoneal lavage with bupivacaine during the operation reduced post-operative total narcotics use in patients who underwent laparoscopic proctectomy, not in rectopexy.