Miracle-dz/UniFAR-FTUs huggingface dataset:
Perception On Accountant’s Roles In The Digital Era: Does It Matter For Z Generation?

Penelitian ini bertujuan untuk mengukur empat faktor yang dapat mempengaruhi niat calon mahasiswa generasi Z untuk memilih jurusan akuntansi sebagai jalur karir. Tiga fakor berasal dari Theory of Planned Behavior sedangkan faktor keempat adalah Digital Era. Data penelitian diperoleh melalui kuesioner yang dibagikan kepada 193 siswa SMA kelas XII di Bandung sebagai calon siswa. Hasil kuesioner diolah menggunakan skala Likert dan Regresi Linier Berganda. Hasil pengujian menunjukkan bahwa keempat variabel independen berpengaruh signifikan terhadap niat calon mahasiswa dalam memilih jurusan akuntansi sebagai jaur karir. Namun pengujian secara parsial menunjukkan bahwa hanya variabel sikap yang berpengaruh signifikan terhadap niat calon mahasiswa dalam memilih jurusan akuntansi. Kesimpulan dari hasil penelitian ini sejalan dengan karakter generasi Z yang menyukai kebebasan dan tidak menyukai otoritas, sehingga hanya sikap sebagai pertimbangan pribadi yang mempengaruhi keputusan mereka. Selain itu, hasil penelitian ini mengungkapkan bahwa faktor era digital tidak berpengaruh terhadap minat mereka dalam memilih jurusan akuntansi yang sejalan dengan karakteristik generasi Z yang dikenal dengan generasi mobile. Generasi ini yang tumbuh dengan kemajuan teknologi dan menjadikan teknologi sebagai bagian dari dirinya agar era digital tidak menjadi faktor penghambat yang dapat mempengaruhi minat Generasi Z dalam memilih jurusan akuntansi.Kata Kunci: Teori Perilaku yang Direncanakan, Generasi Z, Era Digital, dan Jurusan Akuntansi
Children under Fire: Challenging Assumptions about Children's Resilience

Abstract:This article examines perceptions of childhood and child development and theories of human responses to adversity that have arisen within the social and medical sciences and highlights their influence on policy and practice in the context of armed conflict. It highlights how the idea of childhood as a decontextualized and universal life phase characterized by dependence and vulnerability interacts with and is reinforced by a view of war-survivors as traumatized individuals, victims in need of remedial care. It argues for a paradigmatic shift towards understanding childhood as a highly diverse life phase shaped not simply by biological or psychological universals but also, and more importantly, by personal and environmental factors. This paradigmatic shift involves thinking about children as agents of their own development who, even during times of great adversity, consciously act upon and influence the environments in which they live.
Trial design of the MOTheR HDx study: a multicenter, open-label, prospective, randomized study to explore the morbidity and mortality in patients dialyzed with the Theranova HDx in comparison with online hemodiafiltration

ABSTRACT Background Dialysis patients have been maintaining a high rate of cardiovascular morbidity and mortality. For this reason, it is to introduce necessary new technical advances in clinical practice. There is a relation between toxins retention and inflammation, mortality and morbidity. Medium cut-off (MCO) membranes are a new generation of membranes that allow the removal of a greater number of medium-sized molecules compared with high-flux hemodialysis (HF-HD), but retaining albumin. MCO membranes have an increased permeability and the presence of internal filtration. Because of these special properties, MCO generated a new concept of therapy called expanded HD (HDx). Until now, online hemodiafiltration (OL-HDF) has demonstrated its superiority, in terms of survival, compared with HF-HD. However, the comparison between OL-HDF and HDx remains an unsolved question. Methods The MOTheR HDx study trial (NCT03714386) is an open-label, multicenter, prospective, 1:1 randomized, parallel-group trial designed to evaluate the efficacy and safety of HDx compared with OL-HDF in patients treated for dialysis in Spain for up to 36 months. The main endpoint is to determinate whether HDx is non inferior to OL-HDF at reducing the combined outcome of all-cause death and stroke (ischemic or hemorrhagic), acute coronary syndrome (angina and myocardial infarction), peripheral arterial disease (amputation or revascularization) and ischemic colitis (mesenteric thrombosis). Results The trial has already started.
A Novel Defined PANoptosis-Related miRNA Signature for Predicting the Prognosis and Immune Characteristics in Clear Cell Renal Cell Carcinoma: A miRNA Signature for the Prognosis of ccRCC

Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent cancers, and PANoptosis is a distinct, inflammatory-programmed cell death regulated by the PANoptosome. The essential regulators of cancer occurrence and progression are microRNAs (miRNAs). However, the potential function of PANoptosis-related microRNAs (PRMs) in ccRCC remains obscure. This study retrieved ccRCC samples from The Cancer Genome Atlas database and three Gene Expression Omnibus datasets. PRMs were recognized based on previous reports in the scientific literature. Regression analyses were used to identify the prognosis PRMs and construct a PANoptosis-related miRNA prognostic signature based on the risk score. We discovered that high-risk patients had poorer survival prognoses and were significantly linked to high-grade and advanced-stage tumors, using a variety of R software packages and web analysis tools. Furthermore, we demonstrated that the low-risk group had significant changes in their metabolic pathways. In contrast, the high-risk group was characterized by high immune cell infiltration, immune checkpoint expression, and low half-maximum inhibition concentration (IC50) values of chemotherapeutic agents. This suggests that high-risk patients may benefit more from immunotherapy and chemotherapy. In conclusion, we constructed a PANoptosis-related microRNA signature and revealed its potential significance in clinicopathological features and tumor immunity, thereby providing new precise treatment strategies.
Antioxidants in the extract of balinese salak rind (Salacca amboinensis (Becc) Mogea) as an alternative substance to decrease blood sugar levels among Mus musculus L. with hyperglycemia

This study aims to determine the antioxidant potential of Balinese salak rind extract (Salacca amboinensis (Becc) Mogea) (BSRE) as an antihyperglycemic agent in male white mice with hyperglycemia. The research was conducted in three stages extraction of Balinese salak rind using 96% ethanol, phytochemical screening, and antihyperglycemic activity testing. Mice were hyperglycemia induced by alloxan. Mice were divided into five groups consisting of negative control (Aquadest), positive control (Glibenclamide 13 mg/Kg BW), dose 1 (200 mg BSRE/kg BW), dose 2 (400 mg BSRE/kg BW), dose 3 (600 mg BSRE/kg BW). Phytochemical screening showed that the BSRE was positive for containing alkaloids, flavonoids, tannins, saponins, and steroids. The analysis results on the BSRE showed an IC50 value of 81,76 ppm, including strong antioxidant activity. The activity of blood glucose levels showed that BSRE could decrease blood glucose levels of Mus musculus L. with hyperglycemia.
Multigrid inH(div) andH(curl )

Summary. We consider the solution of systems of linear algebraic equations which arise from the finite element discretization of variational problems posed in the Hilbert spacesH(div) andH(curl) in three dimensions. We show that if appropriate finite element spaces and appropriate additive or multiplicative Schwarz smoothers are used, then the multigrid V-cycle is an efficient solver and preconditioner for the discrete operator. All results are uniform with respect to the mesh size, the number of mesh levels, and weights on the two terms in the inner products.
Purchase Channels and Motivation for Exercise in the Slovenian Population: Customer Behavior as a Guarantee of Fitness Center Sustainability

The sustainability of fitness centers depends on two factors: member recruitment and retention, which is why these factors have received attention in recent decades. Temporal trends in fitness center membership purchase channels from 2016 to 2022 and motivation for exercise in 2022 in the Slovenian general population were investigated. The sample included 3419 participants, including 3131 participants (age 31.03 ± 11.31 years, 1430 females) and 288 participants (age 29.39 ± 10.43 years, 110 females) for the first and second objectives, respectively. Data were assessed using a web-based recruitment questionnaire and the EMI-2 motivation questionnaire. Traditional advertising strategies such as radio and flyers are the least effective (only 0.9% of memberships in 2022), while more sophisticated advertising strategies such as the internet and social media are becoming increasingly important in the advertising world (26.6% of memberships in 2022). On the other hand, word of mouth is the most influential method, attracting 51.3% of new members. Females, older members, and Eastern Slovenians were more motivated to exercise by health and esthetic motives, and males and younger members by challenge and competition. Fitness center management should focus on providing the best possible quality of service, tailoring it to the age, gender, and motivation of customers.
Development of a Nurse Turnover Prediction Model in Korea Using Machine Learning

Nurse turnover is a critical issue in Korea, as it affects the quality of patient care and increases the financial burden on healthcare systems. To address this problem, this study aimed to develop and evaluate a machine learning-based prediction model for nurse turnover in Korea and analyze factors influencing nurse turnover. The study was conducted in two phases: building the prediction model and evaluating its performance. Three models, namely, decision tree, logistic regression, and random forest were evaluated and compared to build the nurse turnover prediction model. The importance of turnover decision factors was also analyzed. The random forest model showed the highest accuracy of 0.97. The accuracy of turnover prediction within one year was improved to 98.9% with the optimized random forest. Salary was the most important decision factor for nurse turnover. The nurse turnover prediction model developed in this study can efficiently predict nurse turnover in Korea with minimal personnel and cost through machine learning. The model can effectively manage nurse turnover in a cost-effective manner if utilized in hospitals or nursing units.
Prediction of an Exceptional Storm over France and Southern England (15–16 October 1987)

Abstract The most violent storm to hit France in recent history–with wind gusts of 50 m s−1 and waves of 15 m– is described. The structural and economic damage in France was considerable, but there were very few human casualties. Forecasts issued by the French weather service (Direction de la Meteorologie Nationale or DMN) were successful in predicting the intensity of the storm, and an analysis is presented of how and why such forecasts were possible. In particular, the observations and numerical guidance from the fine mesh PERIDOT and the large-scale EMERAUDE DMN numerical systems and from the European Centre for Medium Range Weather Forecasts (ECMWF) available to operational forecasters are reviewed and the crucial role of proper use of numerical forecasts and human experience is examined.
Coercive Inequalities for Generators of H¨ ormander Type

This thesis investigates coercive inequalities, such as the logarithmic Sobolev and spectral gap inequalities, for generators defined as the sum of squares of degenerate and noncommuting vector fields (such generators are said to be of Hormander type). Situations in which the sum is both finite and infinite are considered. Particular attention is paid to the setting of H-type groups, which are naturally equipped with such generators and an associated sub-Riemannian geometry. The bulk of the monograph consists of three selfcontained but strongly related projects. In the first of these projects the spectral properties of some Hormander-type generators on H-type groups are examined via coercive inequalities. In another direction, it is shown that certain non-trivial Gibbs measures with quadratic interaction potentials on an infinite product of H-type groups satisfy logarithmic Sobolev inequalities. The thesis concludes with a study of the ergodicity of an infinite particle system described by a highly degenerate generator, in which coercive inequalities again play a role.
Detailed implosion modeling of deuterium-tritium layered experiments on the National Ignition Facilitya)

More than two dozen inertial confinement fusion ignition experiments with cryogenic deuterium-tritium layers have now been performed on the National Ignition Facility (NIF) [G. H. Miller et al., Opt. Eng. 443, 2841 (2004)]. Each of these yields a wealth of data including neutron yield, neutron down-scatter fraction, burn-averaged ion temperature, x-ray image shape and size, primary and down-scattered neutron image shape and size, etc. Compared to 2-D radiation-hydrodynamics simulations modeling both the hohlraum and the capsule implosion, however, the measured capsule yield is usually lower by a factor of 5 to 10, and the ion temperature varies from simulations, while most other observables are well matched between experiment and simulation. In an effort to understand this discrepancy, we perform detailed post-shot simulations of a subset of NIF implosion experiments. Using two-dimensional HYDRA simulations [M. M. Marinak, et al., Phys. Plasmas 8, 2275 (2001). ] of the capsule only, these simulations repre.
An Ethnobotanical Survey of Medicinal Plants Used for Primary Health Care from Patan Sher Khan and Surrounding Areas of District Sudhnoti, Azad Jammu and Kashmir, Pakistan

Life on mountains is difficult and people depend on medicinal plants for primary health care. Many of mountain areas of Azad Kashmir are unexplored from taxonomic and ethnobotanical point of view. This study was conducted to document the indigenous knowledge of medicinal plants of village Patan Sher Khan and allied areas of District Sudhnuti Azad Kashmir Pakistan. Field surveys were conducted during March 2020 to March 2021 for collection of medicinal plants knowledge following standard ethnobotanical methods. A total of 120 key informants were interviewed by using semi-structured questioners. The data were analyzed through ethnobotanical indices i.e., Relative frequency of citation (RFC), Use value (UV), Informant consensus factor (ICF) and Fidelity level (FL). A total of 37 medicinal plant species belonging to 32 genera and 25 families were recorded during the study. Dominant ethnomedicinal families were Fabaceae with 4 species followed by Moraceae and Rosaceae with 3 species each. Leaves were the most frequently used parts (36 %) and decoction was preferred medicinal preparation (19 use reports). Highest relative frequency of citation was recorded for Ficus palmata (0.15) followed by Melia azedarchta (0.14) and highest use value was found for Dodonaea viscosa (0.58). The most valuable plant species of the study area are Ficus carica with 8 use reports and 48 use citations, Bauhinia variegata with 7 use reports and 45 use citations. The maximum value of FL was recorded for Berberis lyceum (100 %) and Plantago lanceolate, (100%). Based on documented data the reported ailments were grouped into 9 categories, The ICF values ranges between 0. 33 (sexual) to 0.90 (teeth and urinary). Medicinal plant knowledge is still alive and large papulation of area still depend on medicinal plants for primary healthcare. But medicinal plant knowledge is declining especially among younger people. Hence, there is an urgent need to document such precious knowledge by continuous ethnobotanical studies.
From Play in Nature, to Recreation then Vocation: A Developmental Model for Natural History-Oriented Environmental Professionals

Abstract:Much research on environmental socialization and significant life experiences indicates the primacy of childhood play in wild environments in shaping later adult interest in wild places. Less is known about what happens after childhood. This study investigated the remembered childhood, teen and early adult years of young adults (age 19 to 35) involved with natural history professions and/or highly committed hobbyists, identified as exceptional by environmental leaders. A comparison group of disinterested individuals nominated by the same environmental leaders or identified through a screening questionnaire provided an additional contrast. A four-stage descriptive model emerged from the qualitative data. Participants' natural history involvement evolved from unstructured nature play, to structured recreation and school activities, eventually to natural history dominant professional and serious leisure identities. Results suggest that accumulation of experiences, a complementary interplay of nature-based recreation and formal nature study, interaction with different types of mentors in each stage, evolving environmentally focused activities and exploration of perceptual, physical and intellectual aspects of the environment are key components.
Malacological Survey and Spatial Distribution of Intermediate Host Snails in Schistosomiasis Endemic Districts of Rwanda

Background: Schistosomiasis, due to S. mansoni, is prevalent in Rwanda. However, there is a paucity of information related to the abundance, species, distribution, and infectivity of Schistosoma intermediate host snails. Methods: Snails were collected from 71 sites, including lakeshores and wetlands. Snails obtained were morphologically identified, and cercariae were shed using standard procedures. Cercariae were molecularly characterized using PCR. GPS coordinates were used to generate geospatial maps of snail distribution that were overlaid with geospatial distribution of schistosomiasis among pre-school children in the same areas. Results: Overall, 3653 snails were morphologically classified as Bulinus spp. and 1449 as Biomphalaria spp. A total of 306 snails shed cercariae, 130 of which were confirmed as S. mansoni cercaria by PCR. There was no significant difference in the proportion of S. mansoni cercariae in wetlands compared to lakeshores. Conclusion: Rwandan water bodies harbor an important number of snails that shed S. mansoni cercariae. Furthermore, a strong spatial correlation was observed between the distribution of schistosomiasis in children and the spatial distribution of snail infectivity with S. mansoni. The presence of Bulinus spp. Suggests a potential risk of S. haematobium, although molecular analysis did not show any current transmission of this parasite.
Interaction Mechanism of Composite Propellant Components under Heating Conditions

To examine the interactions between two binder systems—hydroxyl-terminated polybutadiene (HTPB) and hydroxyl-terminated block copolyether prepolymer (HTPE)—as well as between these binders and ammonium perchlorate (AP) at various temperatures for their susceptibility to varying degrees of thermal damage treatment, the thermal characteristics and combustion interactions of the HTPB and HTPE binder systems, HTPB/AP and HTPE/AP mixtures, and HTPB/AP/Al and HTPE/AP/Al propellants were studied. The results showed that the first and second weight loss decomposition peak temperatures of the HTPB binder were, respectively, 85.34 and 55.74 °C higher than the HTPE binder. The HTPE binder decomposed more easily than the HTPB binder. The microstructure showed that the HTPB binder became brittle and cracked when heated, while the HTPE binder liquefied when heated. The combustion characteristic index, S, and the difference between calculated and experimental mass damage, ΔW, indicated that the components interacted. The original S index of the HTPB/AP mixture was 3.34 × 10−8; S first decreased and then increased to 4.24 × 10−8 with the sampling temperature. Its combustion was initially mild, then intensified. The original S index of the HTPE/AP mixture was 3.78 × 10−8; S increased and then decreased to 2.78 × 10−8 with the increasing sampling temperature. Its combustion was initially rapid, then slowed. Under high-temperature conditions, the HTPB/AP/Al propellants combusted more intensely than the HTPE/AP/Al propellants, and its components interacted more strongly. A heated HTPE/AP mixture acted as a barrier, reducing the responsiveness of solid propellants.
Targeting Pro-Survival Autophagy Enhanced GSK-3β Inhibition-Induced Apoptosis and Retarded Proliferation in Bladder Cancer Cells

Advanced bladder cancer (BC) (local invasive and/or metastatic) is not curable even with cytotoxic chemotherapy, immune checkpoint inhibitors, and targeted treatment. Targeting GSK-3β is a promising novel approach in advanced BC. The induction of autophagy is a mechanism of secondary resistance to various anticancer treatments. Our objectives are to investigate the synergistic effects of GSK-3β in combination with autophagy inhibitors to evade GSK-3β drug resistance. Small molecule GSK-3β inhibitors and GSK-3β knockdown using siRNA promote the expression of autophagy-related proteins. We further investigated that GSK-3β inhibition induced the nucleus translocation of transcription factor EB (TFEB). Compared to the GSK-3β inhibition alone, its combination with chloroquine (an autophagy inhibitor) significantly reduced BC cell growth. These results suggest that targeting autophagy potentiates GSK-3β inhibition-induced apoptosis and retarded proliferation in BC cells.
Genetic Characterization of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates in a Tertiary Hospital in Greece, 2018–2022

Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a serious public health issue. The study aimed to identify the antimicrobial resistance and accessory genes, the clonal relatedness, and the evolutionary dynamics of selected CRKP isolates recovered in an adult and pediatric intensive care unit of a tertiary hospital in Greece. Methods: Twenty-four CRKP isolates recovered during 2018–2022 were included in the study. Next-generation sequencing was performed using the Ion Torrent PGM Platform. The identification of the plasmid content, MLST, and antimicrobial resistance genes, as well as the comparison of multiple genome alignments and the identification of core genome single-nucleotide polymorphism sites, were performed using various bioinformatics software. Results: The isolates belonged to eight sequence types: 11, 15, 30, 35, 39, 307, 323, and 512. A variety of carbapenemases (KPC, VIM, NDM, and OXA-48) and resistance genes were detected. CRKP strains shared visually common genomic regions with the reference strain (NTUH-K2044). ST15, ST323, ST39, and ST11 CRKP isolates presented on average 17, 6, 16, and 866 recombined SNPs, respectively. All isolates belonging to ST15, ST323, and ST39 were classified into distinct phylogenetic branches, while ST11 isolates were assigned to a two-subclade branch. For large CRKP sets, the phylogeny seems to change approximately every seven SNPs. Conclusions: The current study provides insight into the genetic characterization of CRKP isolates in the ICUs of a tertiary hospital. Our results indicate clonal dispersion of ST15, ST323, and ST39 and highly diverged ST11 isolates.