Miracle-dz/UniFAR-FTUs huggingface dataset:
Nicotinamide N‐methyltransferase expression in SH‐SY5Y human neuroblastoma cells decreases oxidative stress

Nicotinamide N‐methyltransferase (NNMT) plays a central role in cellular metabolism, regulating pathways including epigenetic regulation, cell signalling, and energy production. Our previous studies have shown that the expression of NNMT in the human neuroblastoma cell line SH‐SY5Y increased complex I activity and subsequent ATP synthesis. This increase in ATP synthesis was lower than the increase in complex I activity, suggesting uncoupling of the mitochondrial respiratory chain. We, therefore, hypothesised that pathways that reduce oxidative stress are also increased in NNMT‐expressing SH‐Y5Y cells. The expression of uncoupling protein‐2 messenger RNA and protein were significantly increased in NNMT‐expressing cells (57% ± 5.2% and 20.1% ± 1.5%, respectively; P = .001 for both). Total GSH (22 ± 0.3 vs 35.6 ± 1.1 nmol/mg protein), free GSH (21.9 ± 0.2 vs 33.5 ± 1 nmol/mg protein), and GSSG (0.6 ± 0.02 vs 1 ± 0.05 nmol/mg protein; P = .001 for all) concentrations were significantly increased in NNMT‐expressing cells, whereas the GSH:GSSG ratio was decreased (39.4 ± 1.8 vs 32.3 ± 2.5; P = .02). Finally, reactive oxygen species (ROS) content was decreased in NNMT‐expressing cells (0.3 ± 0.08 vs 0.12 ± 0.03; P = .039), as was the concentration of 8‐isoprostane F2α (200 ± 11.5 vs 45 ± 2.6 pg/mg protein; P = .0012). Taken together, these results suggest that NNMT expression reduced ROS generation and subsequent lipid peroxidation by uncoupling the mitochondrial membrane potential and increasing GSH buffering capacity, most likely to compensate for increased complex I activity and ATP production.
Ultrasound of Maxillary Sinus

Acute rhinosinusitis may sometimes present non-specific signs and symptoms. The imaging techniques usually used for its diagnosis are invasive and/or expensive (computed tomography, magnetic resonance imaging, standard radiography) and should be performed only in selected cases. Ultrasonography of the maxillary sinuses is seldom mentioned in literature as a diagnosis method of sinusitis. The objective of this material is to introduce maxillary sinuses ultrasonography as a possible and useful method in the diagnosis of acute maxillary sinusitis as well as to present the normal aspects of the maxillary sinuses and the ultrasonographic findings of acute maxillary sinusitis (fluid collections, mucosal thickening). Ultraosnography of the maxillary sinuses is not widely accepted and it is not used on a large scale, but, as the material will demonstrate, almost any alteration of the normal ultrasonographic image is highly suggestive of a pathological process within the sinusal cavity. The role of computed tomography and magnetic resonance imaging in the acute and chronic pathology of the maxillary sinuses remains undoubted, but we believe ultrasonography can play an important role in the diagnosis of uncomplicated acute maxillary sinusitis and its use may reduce costs and avoid unnecessary radiation exposure and antibiotic treatment. Fufezan Otilia* and Asavoaie Carmen Emergency Children Hospital, Romania *Corresponding author: Fufezan Otilia, Emergency Children Hospital, Str. Campeni 2, 400217 Cluj-Napoca, Romania, Tel: +40264534848; Email: otilia.fufezan@gmail.com Published Date: December 29, 2015
Generating Synthetic Healthcare Records Using Convolutional Generative Adversarial Networks

Deep learning models have demonstrated high-quality performance in several areas such as image classification and speech processing. However, creating a deep learning model using electronic health record (EHR) data requires addressing particular privacy challenges that make this issue unique to researchers in this domain. This matter focuses attention on generating realistic synthetic data to amplify privacy. Existing methods for artificial data generation suffer from different limitations such as being bound to particular use cases. Furthermore, their generalizability to real-world problems is controversial regarding the uncertainties in defining and measuring key realistic characteristics. Henceforth, there is a need to establish insightful metrics (and to measure the validity of synthetic data), as well as quantitative criterion regarding privacy restrictions. We propose the use of Generative Adversarial Networks to help satisfy requirements for realistic characteristics and acceptable values of privacy metrics simultaneously. The present study makes several unique contributions to synthetic data generation in the healthcare domain. First, utilizing 1-D Convolutional Neural Networks (CNNs), we devise a new approach to capturing the correlation between adjacent diagnosis records. Second, we employ convolutional autoencoders to map the discrete-continuous values. Finally, we devise a new approach to measure the similarity between real and synthetic data, and a means to measure the fidelity of the synthetic data and its associated privacy risks.
Exercising Real Options Sooner or Later? New Insights from Quantile-Preserving Spreads on how to Hasten or Delay Exercise

Using Quantile-Preserving Spreads and Stochastic Dominance, this paper studies how modifying a real option's characteristic affects the real option holding value and optimal exercise decision. We find that the direction of change in exercise probability and timing depends on the preserved quantile, strike price, time of underlying modification, and whether a modification is symmetric or not. We significantly generalize previously obtained results to an unspecified underlying process and a general call-like payoff function. Our propositions and corollaries apply to various real option and economic policy problems. Specifically, the results are useful to determine a modification of a real option to increase or decrease its exercise probability and timing.
EMOTIONAL INTELLIGENCE AND EMOTION REGULATION STRATEGIES1

Do emotional abilities relate to specifi c strategies of emotion regulation? Do people with higher emotional intelligence (EI) use more effi cient affect regulation strategies? In the current study we tried to answer these questions. Using a sample of 349 undergraduate students, the present study explored the relationships between emotional intelligence (assessed with performance measure) and the habitual use of suppression and reappraisal. Results showed that higher emotional intelligence was related to more frequent use of reappraisal, and less frequent employment of suppression. As in the previous studies, males and females signifi cantly differed in suppression: men suppressed more than women. However, our results revealed that this difference could be attributed only to men with low EI. Emotionally unintelligent men used suppression more frequently not only in comparison to women, but also to men with higher EI. With respect to the habitual use of reappraisal, only men disclosed a signifi cant relation to EI level: those male participants who revealed the highest EI level declared employment of reappraisal more frequently than other groups.
Diversification in Lottery-Like Features and Portfolio Pricing Discounts*

I study the asset pricing implications of cumulative prospect theory on portfolio discounts. I extend Barberis and Huang (2008) and show that a portfolio consisting of lottery-like stocks should trade at a discount due to diversification. This discount can be partially mitigated if lottery-like stocks tend to produce extreme payoffs at the same time. I utilize three empirical settings to support this theoretical prediction: the closed-end fund puzzle, the announcement returns of mergers and acquisitions, and conglomerate discounts. My findings support cumulative prospect theory from an alternative perspective and provide a novel and unifying explanation for three seemingly unrelated phenomena.
Weakly Nonlinear Analysis of Rapidly Decelerated Channel Flow∗

An amplitude evolution equation for the most unstable mode of a flow between two parallel planes is derived under the quasi-steady assumption. The base flow is rapidly decelerated so that the total fluid flux through the cross-section of the channel is equal to zero. The derivation is based on the method of multiple scales which is widely used in weakly nonlinear theory. It is shown that the equation has complex coefficients and is of Ginzburg–Landau type. Explicit formulas for the calculation of the coefficients of this equation are presented. Results of numerical calculations show that the instability is subcritical To appear in IASME
Clinical Characteristics of Frailty in Japanese Rheumatoid Arthritis Patients

Objective The relationship between clinical characteristics and frailty was investigated in rheumatoid arthritis (RA) patients >40 years old. Methods RA patients followed for >1 year were interviewed and diagnosed as frail according to a 5-item frailty score index: (1) weight loss >2 kg within 6 months (WL); (2) slower gait speed (GS); (3) exercise less than once per week (EX); (4) decline in short-term memory (SM); and (5) general fatigue in the past 2 weeks (GF). The relationship between frailty status and background parameters was evaluated. Results Among 739 subjects, frail patients comprised 221, pre-frail patients comprised 203, and robust comprised 315. The most common symptom in the Frailty group was GS, followed by SM, GF, EX, and WL, whereas the most common symptom in the Pre-frailty group was GS followed by SM, GF, WL, and EX. Frailty was significantly correlated with aging. Elderly onset rheumatoid arthritis, disease activity, serum C-reactive protein concentration, degree of joint deformity, activities in daily living (ADL), dementia treated, and glucocorticoid steroid administration demonstrated significant correlations with frailty status, although all factors also demonstrated significant correlation with aging. In addition, the EuroQol score (EQ5D) was significantly correlated with both aging and frailty. Conclusion The results suggest that a remission state for disease activity, ADL, and dementia is correlated with frailty. The most common and primary symptom is GS. Elderly RA patients require careful attention for symptoms of frailty, which may damage the EQ5D score, specifically, the quality of life for RA patients.
The Tame Kernel of Multi-Cyclic Number Fields

There are many results about the structures of the tame kernels of the number fields. In this paper, we study the structure of those fields F , which are the composition of some cyclic number fields, whose degrees over Q are the same prime number q. Then, for any odd prime p 6= q, we prove that the p-primary part of K2OF is the direct sum of the p-primary part of the tame kernels of all the cyclic intermediate fields of F/Q. Moreover, by the approach we developed, we can extend the results to any abelian totally real base field K with trivial p-primary tame kernel. 2010 Mathematics Subject Classification: 11R70
Reverse Takeover, Corporate Governance, and Survivability

A reverse takeover is an alternative method of going public which is less costly than an initial public offering (IPO). Using a sample of reverse takeovers that took place during the 1992–2002 period in the US, this paper investigates the survivability of reverse takeovers by taking their combined governance characteristics into account. We find that surviving firms tend to have greater after-merger cash liquidity, relatively larger acquirers, and longer tenure of boards with board stability. They also tend to have greater ownership by venture capitalists and smaller boards than the failed firms. We conclude that the survivability of reverse takeovers depends not only on the financial conditions of the merging firms, but also on their value-enhancing governance characteristics.
Environment Sound Classification Using Multiple Feature Channels and Attention Based Deep Convolutional Neural Network

In this paper, we propose a model for the Environment Sound Classification Task (ESC) that consists of multiple feature channels given as input to a Deep Convolutional Neural Network (CNN) with Attention mechanism. The novelty of the paper lies in using multiple feature channels consisting of Mel-Frequency Cepstral Coefficients (MFCC), Gammatone Frequency Cepstral Coefficients (GFCC), the Constant Q-transform (CQT) and Chromagram. Such multiple features have never been used before for signal or audio processing. And, we employ a deeper CNN (DCNN) compared to previous models, consisting of spatially separable convolutions working on time and feature domain separately. Alongside, we use attention modules that perform channel and spatial attention together. We use some data augmentation techniques to further boost performance. Our model is able to achieve state-of-the-art performance on all three benchmark environment sound classification datasets, i.e. the UrbanSound8K (97.52%), ESC-10 (95.75%) and ESC-50 (88.50%). To the best of our knowledge, this is the first time that a single environment sound classification model is able to achieve state-of-the-art results on all three datasets. For ESC-10 and ESC-50 datasets, the accuracy achieved by the proposed model is beyond human accuracy of 95.7% and 81.3% respectively.
Left Cerebellary Toxoplasmosis with No Immunodefiency: Case Report

Toxoplasmosis is caused by an infection with an obligate intracellular parasite, Toxoplasma gondii. The patients are usually immunocompromised. It causes a silent infection in healthy individuals. Trimethoprim sulfamethoxazole is the most common drug used for toxoplasmosis. A fifty year old male applied to our out-patient department with the complaint of right hemiparesis, walking difficulty, ear humming and facial asymmetry on May 2010. Magnetic resonance imaging revealed a left cerebellary mass lesion. He was operated and the pathological findings were consistent with ‘toxoplasmosis’; although we could not demonstrate an immunodeficiency in this patient.
Bubble-Creating Stock Market Attacks and Exploitation of Retail Investors’ Behavioral Biases: Widespread Evidence in the Chinese Stock Market

In existing literature, arbitrageurs attack stock prices to burst bubbles. In this paper, we study a novel form of bubble-creating attacks in the stock market, in which speculators implicitly coordinate to pump up the stock price without any significant fundamental news and exploit behavioral-biased investors. We propose a simple model of bubble-creating attacks and provide empirical evidence in the Chinese stock market that is consistent with the model predictions. First of all, stocks with low mutual fund ownership and stocks with high average purchase costs of existing shareholders are more likely to be attacked. Second, stocks with these characteristics experience subsequent price reversals. Third, individual accounts that are like to be held by speculators purchase shares to pump up prices on event days and dump them at the inflated price. These accounts also realize abnormally high return during the event days.
Technology Readiness for Internet of Things (IoT) Adoption in Smart Farming in Thailand

Smart farming, an Internet of Things (IoT) application that uses a combination of sensor networks and artificial intelligence (AI) techniques to optimize growing conditions, is a developing technology that shows promise for farming in Thailand to improve yield and optimize resource use. However, smart farming technology cannot be effective if technological readiness conditions are not in place for its deployment or if farmers do not adopt the technology. This research investigates technology readiness for IoT adoption in smart farming using a survey of Thai firms (n = 395). An extended technology acceptance model (TAM) was deployed for investigation. The study showed that IoT readiness, perceived usefulness (PU), e-learning and institutional support influenced adoption intentions. The implication of this research is that while Thai farmers are not yet ready to adopt smart farming, e-learning and institutional support could be used to prepare farmers for IoT-based smart farming adoption. This study is the first readiness study for smart farming adoption, contributing to the literature on smart farming which is to date mainly technical implementation research.
Access to Pediatric Audiological Evaluation Facilities for Infants and Young Children in the United States: Results from the EHDI-PALS System

Early Hearing Detection and Intervention–Pediatric Audiology Links to Services (EHDI-PALS) is a web-based national directory of pediatric audiology facilities in the United States, launched in October 2012. It was created by a committee of national experts to improve diagnostic audiology follow-up for infants and young children who failed the newborn hearing screening or were suspected of having hearing loss. In this study, data from 1,232 audiology facilities registered in EHDI-PALS were analyzed to identify the location of facilities, types of diagnostic hearing tests offered, and the number of children under five years of age who were diagnosed with hearing loss. Some states had almost 15 times as many registered facilities as other states, suggesting that access to quality diagnostic hearing testing for infants and young children is still a major public health problem in many states. Approximately 90% of registered facilities have equipment necessary for diagnosing hearing loss in children over seven months of age. However, less than 70% of facilities had appropriate auditory brainstem response (ABR) equipment required for effectively evaluating hearing status for infants six months of age or younger. The data suggest that steps need to be taken to increase the number of pediatric audiology facilities registered in EHDI-PALS in each state to efficiently deal with the large number of infants and young children being referred from newborn hearing screening programs. Disclosures: The authors have no financial or non-financial disclosures. Acknowledgements: Work on this article was supported in part by cooperative agreement #U52MC04391 with the Maternal and Child Health Bureau of the Health Resources Services Administration (HRS) United States Department of Health and Human Services (HHS). Content and conclusions are those of the authors and should not be construed as the official position or policy of, nor should any endorsements be inferred by, HRSA or the U.S. Government. Acronyms: AAA = American Academy of Audiology; ABR = auditory brainstem response; ASHA = American Speech, Language and Hearing Association; CPA = conditioned play audiometry; ASSR = auditory steady state responses; DHH = deaf or hard of hearing; DPOAE = distortion-product otoacoustic emissions; EHDI = Early Hearing Detection and Intervention; EHDI-PALS = Early Hearing Detection and Intervention–Pediatric Audiology Links to Services; HL = hearing loss; OAE = otoacoustic emissions; TEOAE = transient evoked otoacoustic emissions; VRA = Visual Reinforcement Audiometry
pREDicTiVE FacToRS FoR UnSaTiSFacToRY EVoLUTion oF UnSTaBLE HipS in BRain paLSY SUBMiTTED To JoinT REconSTRUcTion

1 Associate PhD Professor, Medical Sciences College, Santa Casa de São Paulo, Head of the Neuromuscular Diseases Group. 2 Associate PhD Professor, Medical Sciences College, Santa Casa de São Paulo, Head of the Pediatric Orthopaedics Group. 3 Assistant PhD Professor, Medical Sciences College, Santa Casa de São Paulo, Consultant. 4 Assistant Doctor, student of the Post-Graduation Course, Medical Sciences College, Santa Casa de São Paulo. 5 Resident Doctor of the Department. 6 Assistant Doctor of the Department. inTRoDUcTion Hip deformities in children affected by spastic Brain Palsy is frequent, ranging from 25 to 75%, being directly related to the severity of neurological damage, thus being more prevalent in quadriparetic and non-ambulating patients (1-8). The etiology of deformities is multifactorial, that is, an association of factors predisposing changes, initially postural, up to the so-called deformities, namely: muscle unbalance, acting in a peculiar anatomy with fetal patterns, represented by valgusing and femoral anteversion, and neurological deficit degree, affecting patients’ function, once the delay or absence of ambulation does not favor physiological correction of the regional anatomy (3,6-8). Changes range from sub dislocation to full dislocation of the joint. Combined factors are young age, the high growth potential, and bone remodeling (8,9). The results of deformities in sub dislocations and dislocations are the reduced joint motion, positioning difficulties, sitting ability reduced or lost, perineal hygiene problems, and the emergence of pressure sores (3,5,8,10-13). It is believed that, despite of the difficulties on evaluating those severely compromised patients, approximately one third to half of these evolve with pain at hip motion if left untreated (1,4,8). It is a consensus in literature that the optimal treatment for those spastic patients with changes on hip joint is the preventive one, when those present clinically with motion restraints at abduction and flexion, the so-called “hips at risk”, upon release of spastic musculature causing muscle unbalance. After that phase, the way is surgical reconstruction, aiming to fix the so-called deformities by combining soft parts release to pelvic and femoral osteotomies (1,2,5,7,8,11,13). The outcomes of such treatment are, according to most of the authors, satisfactory, but it presents the challenge of finding uniform groups of patients for better evaluating and possibly comparing outcomes, with the major reason for this difficulty being the fact that those patients show spasticity. The objective of the present study is to identify which factors presented by patients would be indicative of an unsatisfactory development in the treatment of spastic hip sub dislocation and/ or dislocation when submitted to surgical reconstruction. pREDicTiVE FacToRS FoR UnSaTiSFacToRY EVoLUTion oF UnSTaBLE HipS in BRain paLSY SUBMiTTED To JoinT REconSTRUcTion
Forum Matteuci

This paper responds to the Forum contribution by Piovesan & Adams (2000) who criticized the results obtained by the EUROFLUX network on carbon fluxes of several European forests. The major point of criticism was that the data provided by EUROFLUX are inconsistent with current scientific understanding. It is argued that understanding the terrestrial global carbon cycle requires more than simply restating what was known previously, and that Piovesan & Adams have not been able to show any major conflicts between our findings and ecosystem or atmospheric-transport theories.
Une pauvreté très présente dans les villes-centres des grands pôles urbains

En France metropolitaine, en 2012, le taux de pauvrete est le plus eleve dans le Nord et le Sud-Est, ainsi qu'en Seine-Saint-Denis. Le taux de pauvrete est le plus important dans les villes-centres des grandes aires urbaines, ou la pauvrete touche particulierement les familles monoparentales, les familles nombreuses et les menages jeunes, ainsi qu'en dehors de l'influence des villes. Les inegalites de niveaux de vie a l'interieur des regions et des departements sont souvent fortes ; elles sont les plus prononcees a Paris, dans les Hauts-de-Seine, et en Haute-Savoie, du fait d'un niveau de vie particulierement eleve de la partie aisee de la population qui y habite. Le niveau de vie median est generalement plus eleve dans l'espace urbain, en particulier dans les couronnes des grands poles urbains. Pour les personnes les plus pauvres, la part des prestations sociales dans le revenu disponible est importante et varie fortement selon les regions ; elle est la plus elevee dans les villes-centres ou elle represente en moyenne 46 % du revenu disponible pour les 10 % de personnes les plus modestes. A l'inverse, pour les personnes les plus aisees, la part des revenus du patrimoine est alors predominante : dans les villes-centres, qui concentrent souvent les plus fortes inegalites, elle represente en moyenne 30 % du revenu disponible pour les 10 % de personnes les plus aisees.