Miracle-dz/UniFAR-FTUs huggingface dataset:
An integrated architectural and structural design concept by using local, salvaged timber

Our research-based design approach suggests an integrated architectural and structural design concept by using local, salvaged timber in a “material and connection – structure – architecture” sequence, which is in line with Neri Oxman´s discussion of the “Form First, Structure First, Material First: the Designer’s Causality Dilemma”. Following the philosophy of design-build, locally available, salvaged wooden materials connected with wooden nails only is the main design driver. The material, its property, size, and availability, as well as the wooden nail connection are explored separately. The merger of material and the specific connection results in structurally tested prototype-assemblies and previously unnoticed insights respectively. Together with a long-term observation from exposure to the natural environment as well as architectural requirements according to its prototypical use, the findings from the prototype-assemblies are feeding back the design process, as finally showcased by a natural trail project for the city of Kouvola, Finland. The proposed trail meets the requirements of a cheap, fast, replaceable, and sustainable solution, by simultaneously including multiple modular elements for a pedestrian path and a central, partly curved plaza-like area. Future work will focus on smoothening the workflow and on structural and architectural optimization with special focus on the wooden nail connections, and associated assembly geometries.
CNNs efﬁciently learn long-range dependencies

The role of feedback (or recurrent) connections is a fundamental question in neuroscience and machine learning. Recently, two benchmarks [1, 2], which require following paths in images, have been proposed as examples where recurrence was considered helpful for efﬁciently solving them. In this work, we demonstrate that these tasks can be solved equally well or even better using a single efﬁcient convolutional feed-forward neural network architecture. We analyze ResNet training regarding model complexity and sample efﬁciency and show that a narrow, parameter-efﬁcient ResNet performs on par with the recurrent and computationally more complex hCNN and td+hCNN models from previous work on both benchmarks.
Neural Fisher Discriminant Analysis: Optimal Neural Network Embeddings in Polynomial Time

Fisher’s Linear Discriminant Analysis (FLDA) is a statistical analysis method that linearly embeds data points to a lower dimensional space to maximize a discrimination criterion such that the variance between classes is maximized while the variance within classes is minimized. We introduce a natural extension of FLDA that employs neural networks, called Neural Fisher Discriminant Analysis (NFDA). This method finds the optimal two-layer neural network that embeds data points to optimize the same discrimination criterion. We use tools from convex optimization to transform the optimal neural network embedding problem into a convex problem. The resulting problem is easy to interpret and solve to global optimal-ity. We evaluate the method’s performance on synthetic and real datasets.
Appendix for “Comprehensive Knowledge Distillation with Causal Intervention”

Datasets. CIFAR-10 is an image classification dataset. It contains 50,000 training images and 10,000 test images of 10 classes. We adopt the standard data augmentation strategy on CIFAR datasets, i.e., padding 4 pixels on each side of an image and randomly flipping it horizontally, and then cropping it to 32 × 32 size. CIFAR-100 comprises similar images to those in CIFAR-10, but has 100 classes. Tiny ImageNet is a subset of ImageNet. It has 200 classes with 100,000 training images and 10,000 test images. We adopt the standard data argumentation, i.e., padding 8 pixels on each side of an image and randomly flipping it horizontally, and then randomly cropping it to 64 × 64 size. ImageNet is a large-scale image classification dataset containing 1.28 million training images and 50,000 validation images of 1000 classes. The standard augmentation [6, 4] is adopted.
ResponsivenessImportance of MEK in Neutrophil Microbicidal

Exposure of neutrophils to inﬂammatory stimuli such as the chemoattractant FMLP leads to activation of responses including cell motility, the oxidative burst, and secretion of proteolytic enzymes. A signaling cascade involving sequential activation of Raf-1, mitogen-activated protein kinase (MEK), and extracellular signal regulated kinase (ERK) is also rapidly activated after agonist exposure. The temporal relationship between these events suggests that the kinases may be involved in triggering the effector functions, but direct evidence of a causal relationship is lacking. To assess the role of the MEK/ERK pathway in the activation of neutrophil responses, we studied the effects of PD098059, a potent and selective inhibitor of MEK. Preincubation of human neutrophils with 50 m M PD098059 almost completely ( > 90%) inhibited the FMLP-induced activation of MEK-1 and MEK-2, the isoforms expressed by neutrophils. This dose of PD098059 virtually abrogated chemoattractant-induced tyrosine phosphorylation and activation of ERK-1 and ERK-2, implying that MEKs are the predominant upstream activators of these mitogen-activated protein kinases. Pretreatment of neutrophils with the MEK antagonist inhibited the oxidative burst substantially and phagocytosis only moderately. In addition, PD098059 antagonized the delay of apoptosis induced by exposure to granulocyte-macrophage CSF. However, the effects of PD098059 were selective, as it failed to inhibit other responses, including chemoattractant-induced exocytosis of primary and secondary granules, polymerization of F-actin, chemotaxis, or activation of phospholipase A 2 . We conclude that MEK and ERK contribute to the
Radical chemistry at a UK coastal receptor site – Part 2: experimental radical budgets and ozone production

In our companion paper (Woodward-Massey et al., 2022), we presented measurements of radical species and OH reactivity ( k’ OH ) made in summer 2015 during the ICOZA (Integrated Chemistry of OZone in the Atmosphere) field campaign 20 at the Weybourne Atmospheric Observatory, a site on the east coast of the UK. In to form new RO 2 species that undergo further reaction with NO before eventually forming HO 2 . This type of chemistry serves to reduce the rate of RO 2 → HO 2 propagation and could help to explain the differences between experimental 540 production and destruction rates of HO 2 and RO 2 found for ICOZA.
Kirkman Triple Systems with Subsystems (cid:3)

A Steiner triple system of order v , STS( v ), together with a resolution of its blocks is called a Kirkman triple system of order v , KTS( v ). A KTS( v ) exists if and only if v (cid:17) 3 (mod 6). The smallest order for which the KTS( v ) have not been classi(cid:12)ed is v = 21, which is also the smallest order for which the existence of a doubly resolvable STS( v ) is open. Here, KTS(21) with STS(7) and STS(9) subsystems are classi(cid:12)ed, leading to more than 13 million KTS(21). In this pro-cess, systems missing from an earlier classi(cid:12)cation of KTS(21) with nontrivial automorphisms are encountered, so such a classi(cid:12)cation is redone.
Surface contaminants inhibit the osseointegration of orthopaedic implants

by LINDSAY ANN BONSIGNORE The most important factor contributing to short-term and long-term success of cementless total joint arthroplasties is osseointegration. Osseointegration is the process by which a direct structural and functional connection between living bone and the surface of an implant is made. Surface contaminants may remain on orthopaedic implants after sterilization procedures and impair osseointegration. For example, specific lots of hip replacement Sulzer Inter-OP acetabular shells that were associated with impaired osseointegration and early failure rates were found to be contaminated with both bacterial debris and machine oil residues. However, few osseointegration studies have focused on surface contaminants and their effect on implant integration is unknown. Therefore, we developed a novel murine model that provides quantitative and reproducible measurements of osseointegration to study the effect of surface contaminants. We found that a rigorous cleaning procedure significantly enhances osseointegration compared to implants that were autoclaved. The most likely interpretation of these results is that surface contaminants on the autoclaved implants inhibit osseointegration. Using our murine model, we also found that Gram-negative bacterial derived LPS or machine oil residues on implants inhibit osseointegration. Ultrapure LPS adherent to titanium alloy
Phospholipid composition and resistance to vitrification of in vivo blastocyst of a Brazilian naturalized porcine breed

ES ABSTRACT Piau porcine blastocysts were submitted to MALDI-TOF to identify the main phospholipids (PL). After that, in vivo blastocysts (D6) were vitrified (n=52), non-vitrified were used as control (n=42). After warming, blastocysts were in vitro cultured to assess re-expansion and hatching at 24 and 48 hours. Finally, at 48 hours, hatched blastocysts were submitted to RT-qPCR searching for BCL2A1, BAK, BAX and CASP3 genes. For MALDI-TOF, the ion intensity was expressed in arbitrary units. Blastocyst development was compared by Qui-square (P< 0.05). Among the most representative PL was the phosphatidylcholine [PC (32:0) + H]+; [PC (34:1) + H]+ and [PC (36:4) + H]+. Beyond the PL, MALDI revealed some triglycerides (TG), including PPL (50:2) + Na+, PPO (50:1) + Na+, PLO (52:3) + Na+ and POO (52:2) + Na. Re-expansion did not differ (P> 0.05) between fresh or vitrified blastocysts at 24 (33.3%; 32.7%) or 48 hours (2.4%; 13.5%). Hatching rates were higher (P< 0.05) for fresh compared to vitrified at 24 (66.7%; 15.4%) and 48 hours (97.6%; 36.0%). BAX was overexpressed (P< 0.05) after vitrification. In conclusion, Piau blastocysts can be cryopreserved by Cryotop. This study also demonstrated that the apoptotic pathway may be responsible for the low efficiency of porcine embryo
Leaf Tipburn in Cauliflower as Affected by Cultivar, Calcium Sprays, t

Two separate field experiments w of Ca sprays and N fertilizer rate on lea Blanche’, and ‘Imperial 10-6’ cauliflower ‘Snow Crown’ each year and varied with y Delaying planting of ‘Snow Crown’ by 3 w and decreased the number of tipburned leav CaCl2 or calcium chelate had no effect on cau incidence. Increasing N fertilizer rate from 6 yield without significantly affecting tipburn nontipburned leaves were two to five time leaves of comparable physiological age. Bas tions, regardless of tipburn status. Use of method of reducing tipburn incidence in ca Leaf tipburn in cauliflower is characterized as a tip necrosis of young expanding leaves surrounding the enlarging curd. Necrotic leaves can lower product quality and, in severe cases, may discolor the curd due to secondary pathogen infection and cause a loss in marketable heads (Maynard et al., 1981). Similar disorders have been reported in other vegetable crops, including cabbage (Maynard et al., 1965), brussels sprouts Received for publication 5 July 1989. Paper no. 17,432 of the Journal Series, Minnesota Agricultural Experiment Station. I thank Glenn Titrud for assisting with field plot maintenance. The cost of publishing this paper was defrayed in part by the payment of page charges. Under postal regulations, this paper therefore must be hereby marked advertisement solely to indicate this fact.
Protein carbonyls and antioxidant defenses in corkwing wrasse () from a heavy metal polluted and a PAH polluted site

polluted Abstract: 19 The use of fish in environmental monitoring has become increasingly important in recent 20 years as anthropogenic substances, many of which function as prooxidants, are accumulating 21 in aquatic environments. We have measured a battery of antioxidant defenses as a measure of 22 oxidative status, as well as protein carbonylation as a measure of oxidative damage, in 23 corkwing wrasse ( Symphodus melops ) captured near a disused copper mine, where water and 24 sediment are contaminated with heavy metals, and an aluminum smelter, a site contaminated 25 with PAHs. Results were compared to two different reference sites. Fish at the heavy metal 26 site had lower glucose-6-phosphate dehydrogenase activity and elevated protein carbonyls 27 (1.8 times) compared to fish from the reference site. At the PAH site, EROD was increased 2- 28 fold, while total glutathione and methemoglobin reductase concentration, were decreased. No 29 differences were seen in protein carbonyl levels at the PAH site. Measures of both antioxidant 30 defenses and oxidative damage should be used when assessing effects of xenobiotics on 31 oxidative stress in fish species. 32
Effect of Self Efficacy, Positive Belief and Social Support on Post-Trauma Stress Disorder (PTSD) in Postpartum Mother at Kediri District

Introduction: Childbirth is a stressfull event, frequently labor can result PTSD in post partum period. The impact of post partum PTSD is a bonding issue between mother and baby that can affect the mother's ability to adapt to her new role. To cope chilbearing period mother need an adequate coping source that includes self efficacy, positive belief and social support. The study describe the effect of self efficacy, positive belief and social support on occurrence post-trauma stress disorder (PTSD) in postpartum period. Method: The study used cross sectional design. The sampling technique was purposive sampling and the numbers of samples were 92 respondents. The instruments for evaluate PTSD and coping was Modified PPQ, PMP-SE, PPSS and PBRS. Result: Pearson correlation test showed that all variables have p value <0,05, which means that all variables have effect on occurrence post-trauma stress disorder (PTSD) in postpartum period. Linear Regression Test showed that positive belief with R square -0.850 is the variable that most contribute on occurrence post-trauma stress disorder (PTSD) than the others in negative impact. Conclusion: All variables have contribution, but positive belief has the most significant influence on occurrence post-trauma stress disorder (PTSD) in negative relationship. Therapeutic Activity Therapy in primary setting is needed to help pregnant women develop positive belief in preparing labor. Copyright
Growth through Inter-sectoral Knowledge Linkages

The majority of innovations are developed by multi-sector firms. The knowledge needed to invent new products is more easily adapted from some sectors than from others. We study this network of knowledge linkages between sectors and its impact on firm innovation and aggregate growth. We first document a set of sectoral-level and firm-level observations on knowledge applicability and firms’ multi-sector patenting behavior. We then develop a general equilibrium model of firm innovation in which inter-sectoral knowledge linkages determine the set of sectors a firm chooses to innovate in and how much R&D to invest in each sector. It captures how firms evolve in the technology space, accounts for cross-sector differences in R&D intensity, and describes an aggregate model of technological change. The model matches new observations as demonstrated by simulation. It also yields new insights regarding the mechanism through which sectoral fixed costs of R&D affect growth.
Optimal Binary Signaling for Correlated Sources over the Orthogonal Gaussian Multiple-Access Channel

Optimal binary communication, in the sense of minimizing symbol error rate, with nonequal probabilities has been derived in [1] under various signalling configurations for the single-user case with a given average energy E. This work extends a subset of the results in [1] to a two-user orthogonal multiple access Gaussian channel (OMAGC) transmitting a pair of correlated sources, where the modulators use a single phase or basis function and have given average energies E1 and E2, respectively. These binary modulation schemes fall in one of two categories: (1) transmission signals are both nonnegative, or (2) one transmission signal is positive and the other negative. To optimize the energy allocations for the transmitters in the two-user OMAGC, the maximum a posteriori detection rule, probability of error, and union error bound are derived. The optimal energy allocations are determined numerically and analytically. Both results show that the optimal energy allocations coincide with corresponding results from [1]. It is demonstrated in Chapter 3 that three parameters are needed to describe the source. The optimized OMAGC is compared to three other schemes with varying knowledge about the source statistics, which influence the optimal energy allocation. A gain of at least 0.73 dB is achieved when E1 = E2 or 2E1 = E2. When E1 E2 a gain of at least 7 dB is observed. i
Digital Media Activism A Situated, Historical, and Ecological Approach Beyond the Technological Sublime

: This chapter engages with the notion of digital media activism. The starting point is that current studies often fall short in situating digital media activism within a longer historical trajectory and in the context of a complex media ecology, comprising both old and new media interactions. As a result, they frequently assume activism has been (and is) predominantly “ digital ” . Countering this assumption, this chapter argues for the importance of establishing both a historical perspective and a contextualized ecological lens of this concept, allowing for a nuanced analysis of activist media practices beyond the technological sublime. In the first part, the chapter situates the notion of digital media activism within broader research on media activism and then disentangles its constitutive elements, i.e. “ digital, ” “ media, ” and “ activism. ” In the second part, the chapter brings together attempts to historicize and contextualize digital media activism. It shows that a historical perspective is able to capture the continuities and evolution in relation to a long history of technologically mediated activism. Then, it illustrates how media ecology perspectives can contextualise digital activism by (a) identifying the coexistence of multiple media practices and artefacts; (b) elucidating motivations and obstacles in the adoption and rejection of digital tools; (c) shedding light on how citizens purposely disconnect from media technologies as a form of resistance.
Heat Shock Proteins and Protection of Proliferation and Translation in Mammalian Cells1

The characteristics of heat shock protein(s) (HSP) and thermotolerance induction were examined in Chinese hamster ovary cells following two diverse nonlethal heat shocks: a continuous 41Â°exposure and a 45Â°,5-min exposure. While induction of both HSP and thermotolerance were observed to initially develop simultaneously, a significant period was observed during which HSP induction was not accompanied by any further increase in the cells' ability to survive a thermal stress. Conversely, the achievement of the full tolerant state, as measured by colony survival, correlates in these instances with the moment at which development of the induction of HSP either ceased or began to be repressed. When a 99% lethal 45Â°,22-min heat shock was examined, HSP and a thermal resistance were again observed to develop synchronously, despite the fact that the tolerance was measured in only 1% of the cell population. In this instance, a new protein of molecular weight 66,000 was observed which was not visibly induced by either of the two nonlethal treatments. Finally, the ability of heat-shocked thermotolerant cells to trans late proteins following a second heat challenge (protection of translation) was investigated as an alternative measure of ther motolerance. While a protection of translation which encom passed several normal cellular proteins was observed, the phe nomenon paralleled the induction and repression phases of HSP synthesis and was therefore not related to thermotolerance.
Metabolism of l-/j-D-Arabinofuranosylcvtosine in Leukemia L1210: Nucleoside and Nucleotide Kinases in Cell-free Extracts1

SUMMARY The phosphorylation of l-/3-D-arabinofuranosylcytosine (ara-C) and other nucleosides and nucleotides was studied in cell-free extracts of leukemia L1210 and a subline (L1210/ara-C) resistant to the drug. The specific activities of ara-C kinase, deoxycytidine kinase, and deoxyguanosine kinase were decreased by 95, 98, and 87%, re spectively, in the resistant subline. There was no change in the activities of other nucleoside and nucleotide kinases, with the exception of minor decreases in deoxyadenosine and deoxythymidine kinase activities. The re sults suggest that the phosphorylation of deoxycytidine and ara-C, and apparently also of deoxyguanosine, was mediated by the same enzyme. ara-C 5'-monophosphate, was identical in extracts LI210 and L1210/ara-C. These findings strongly suggest that the reduced phosphorylation is concentration of kinase in and exclude alternative ex planations tion inhibitor or an increased rate of dephosphorylation of the were = 0.6 ^M) of ara-C phos phorylation (Km = 25 ^M) in cell-free extracts of leukemia L1210. The phosphorylation of ara-C is, there fore, mediated exclusively by deoxycytidine kinase. De oxyguanosine kinase activity was inhibited 84% by ara-C and 98% by deoxycytidine, but deoxyguanosine did not inhibit phosphorylation of ara-C. These results suggest that the affinity of the substrates for deoxycytidine kinase decreases in the order deoxycytidine, ara-C, and deoxy guanosine, assuming that the phosphorylation of the latter nucleoside was mediated by this enzyme.
Geotechnical Tailings Characterization from Cuiabá Mine Site to Support a Dry Stacking Disposal Design for Cuiabá Dam

The main advantages of Filtered Tailings (FT) are related to water reduction in tailings disposal when compared with other methods, once it allows the geomaterial to be disposed close to optimum water content, thus allowing a better tailings compaction, and consequently increasing tailings shear strength for both drained and undrained conditions. Another advantage is the significant amount of water recovery during ore beneficiation process, especially in mining projects in dry areas. However, as the main FT disposal designs in operation worldwide are located in drier regions, this Tailings Storage Facility (TSF) method may be a challenge for tropical regions as they generally present a positive water balance. As a consequence, tailings can be saturated and present contractive behaviour if the disposal has not been made properly and compaction has not been well controlled. Thus, this paper presents the geotechnical characterization of tailings generated in Cuiabá Mine Site to support the applicability of FT technique in dry stacking design (compacted FT disposal for buttressing downstream of the dam embankment and across the tailings reservoir). It included seismic piezocone – SCPTU tests of tailings disposed in the reservoir and laboratory tests with disturbed tailings samples at different void ratios to evaluate the effect of compaction effort on the geotechnical parameters of FT to support this new TSF method. The main results obtained from the geotechnical tests to support the design have shown: (i) tailings inside the existing TSF have presented contractive behaviour under high strain conditions and undrained strength ratio of 0.21; (ii) the denser the tailings, the higher the undrained strength ratio and the total friction angle. Besides, the contractive or quasi-steady state behaviour obtained to higher void ratios changed to quasi-steady state or strain-hardening behaviour with density increase; and (iii) the tailings critical state friction angle was closed to 32º.