Miracle-dz/UniFAR-FTUs huggingface dataset:
DAMPAK PANDEMIC COVID 19 TERHADAP REAKSI PASAR PADA SEKTOR CONSUMER GOODS INDUSTRY DI BURSA EFEK INDONESIA

Penelitian ini bertujuan untuk meneliti Dampak Pandemic COVID-19 sebagai bencana darurat nasional terhadap return pada saham sub sektor Consumer Good Industry di Bursa Efek Indonesia yang dilihat dari perbedaan average abnormal return saham sebelum dan sesudah Pandemic COVID-19 ditetapkan sebagai bencana darurat nasional pada tanggal 2 Maret 2020. Populasi dalam penelitian ini adalah perusahaan sub sektor Consumer Good Industry di Bursa Efek Indonesia dengan jumlah 44 perusahaan sub sektor Consumer Good Industry. Dengan menggunakan metode census sampling meliputi keseluruhan populasi. Penelitian difokuskan pada periode jendela, yaitu 10 hari sebelum dan 10 hari sesudah tanggal peristiwa. Data dianalisis dengan menggunakan uji paired sample t-test. Dari penelitian yang dilakukan diketahui bahwa tidak terdapat perbedaan sebelum dan sesudah Pandemic COVID-19 ditetapkan sebagai bencana darurat nasional terhadap return saham perusahaan sub sektor Consumer Good Industry di Bursa Efek Indonesia. Hal ini dapat diketahui dari adanya penurunan average abnormal return pada periode jendela sesudah ditetapkannya Pandemic COVID-19 sebagai bencana darurat nasional. Adapun nilai average abnormal return periode jendela sebelum peristiwa adalah 0,00949 dan periode jendala sesudah adalah peristiwa -0,00252.
A scoping review of high-fidelity bench models for teaching closed reduction of distal radial fractures

This article was migrated. The article was marked as recommended. Introduction: Simulation training can be beneficial for developing clinical skills without risks to patients. This review considers the literature on simulation models used for teaching closed reduction (manipulation) procedures for distal radius (wrist) fractures, particularly high-fidelity models, and the evidence supporting the use of such models. Methods: A scoping review of Medline and Embase was performed. Results: Five articles described low-fidelity models, predominantly focussing on low costs and teaching basic principles. Three articles and two commentary pieces discussing high-fidelity models were identified. Discussion: Attitudes towards a high-fidelity simulator were assessed by Egan et al. (2013), who found the majority of participants to be in favour of the model’s use as a teaching tool, although participant selection may have been subject to bias. Mayne et al. (2016) subsequently used a high-fidelity model including radio-opaque markers and more objective measurements tools to assess orthopaedic trainees’ closed reduction technique and adequacy of the achieved fracture position and casting. Seniority correlated with higher scores on objective structured assessment of technical skills (OSATS) and global rating scores (GRS) but not radiological measures of fracture position or cast quality, and over 90% of all participants achieved an adequate reduction. Seeley et al. (2017) used radiological measurements and time to task completion with another high-fidelity reduction model. The two most experienced participant groups could not be differentiated on any radiological measures of fracture reduction or on the time taken for reduction, although these groups were significantly better than the most junior participants. Conclusion: The discussed models appear helpful to teach inexperienced participants the basic principles and steps in a procedures but a plateau effect appears to limit the potential benefit to more experienced learners. The constraints of educators’ time and financial costs may influence the usage of such models in this type of training.
The Roles of Wind and Sea Ice in Driving the Deglacial Change in the Southern Ocean Upwelling: A Modeling Study

The Southern Ocean (SO) played a fundamental role in the deglacial climate system by exchanging carbon-rich deep ocean water with the surface. The contribution of the SO’s physical mechanisms toward improving our understanding of SO upwelling’s dynamical changes is developing. Here, we investigated the simulated transient SO atmosphere, ocean, and sea ice evolution during the last deglaciation in a fully coupled Earth system model. Our results showed that decreases in SO upwelling followed the weakening of the Southern Hemisphere surface westerlies, wind stress forcing, and Antarctic sea ice coverage from the Last Glacial Maximum to the Heinrich Stadial 1 and the Younger Dryas. Our results support the idea that the SO upwelling is primarily driven by wind stress forcing. However, during the onset of the Holocene, SO upwelling increased while the strength of the wind stress decreased. The Antarctic sea ice change controlled the salt and freshwater fluxes, ocean density, and buoyancy flux, thereby influencing the SO’s dynamics. Our study highlighted the dynamic linkage of the Southern Hemisphere westerlies, ocean, and sea ice in the SO’s latitudes. Furthermore, it emphasized that zonal wind stress forcing and buoyancy forcing control by sea ice together regulate the change in the SO upwelling.
Evaluation of Brazilian Organoclay Synthesized in the Laboratory and Commercial

Bentonite clays organically modified with quaternary ammonium salt, of which features enable to interact with organic compounds, have great potential use for environmental remediation, such as adsorption of organic compounds from wastewater. In this study, the natural clay ‘bofe’ had its properties modified by the organophilization with cation exchange linked to quaternary ammonium salt (benzalkonium chloride). The commercial clay Spectrogel, provided by Spectrochem, was also studied for comparison with sample modified in laboratory. The clays had been characterized by use of x-ray diffraction, scanning electron microscopy, energy dispersive x-ray techniques, thermogravimetric analysis, and differential scanning calorimetry. The organophilic character was evaluated by swelling capacity test in water. There was an increase in the basal spacing, in the presence of carbon and chlorine, and in the new decomposition stage for modified clays, attributed to the organic matter released from quaternary ammonium salt. Such fact confirms how effective is the synthesis of the organoclay and similar behavior for the organoclays modified in laboratory and commercial. The potential for removal of petroleum derived from wastewaters was verified, showing potential use for environmental remediation.
The use of handgrip strength (HGS) in outpatient care for patients with Alzheimer's Disease

— To evaluate the contribution of handgrip strength (HGS) in outpatient care for elderly patients with Alzheimer’s disease (AD) . Cross-sectional study, with AD patients, >65 years of age, who underwent cognitive, nutritional and HGS assessment, International Physical Activity Questionnaire (IPAQ-SF) and Disability Assessment in Dementia (DAD). The data were compared to a similar control group (CG) composed of 51 elderly people, with p <0.05. The 43 elderly people with AD exhibited lower HGS scores when compared to the CG (13.4±8.2 vs 17.5±8.0; p=0.008, Mann-Whitney). There was no difference in HGS according to the severity of dementia, cognitive aspects, the IPAQ-SF and in the
Pathogenic Germline Variants in Cancer Susceptibility Genes in Children and Young Adults With Rhabdomyosarcoma

PURPOSE Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue sarcoma and accounts for 3% of all pediatric cancer. In this study, we investigated germline sequence and structural variation in a broad set of genes in two large, independent RMS cohorts. MATERIALS AND METHODS Genome sequencing of the discovery cohort (n = 273) and exome sequencing of the secondary cohort (n = 121) were conducted on germline DNA. Analyses were performed on 130 cancer susceptibility genes (CSG). Pathogenic or likely pathogenic (P/LP) variants were predicted using the American College of Medical Genetics and Genomics (ACMG) criteria. Structural variation and survival analyses were performed on the discovery cohort. RESULTS We found that 6.6%-7.7% of patients with RMS harbored P/LP variants in dominant-acting CSG. An additional approximately 1% have structural variants (ATM, CDKN1C) in CSGs. CSG variants did not influence survival, although there was a significant correlation with an earlier age of tumor onset. There was a nonsignificant excess of P/LP variants in dominant inheritance genes in the patients with FOXO1 fusion–negative RMS patients versus the patients with FOXO1 fusion–positive RMS. We identified pathogenic germline variants in CSGs previously (TP53, NF1, DICER1, mismatch repair genes), rarely (BRCA2, CBL, CHEK2, SMARCA4), or never (FGFR4) reported in RMS. Numerous genes (TP53, BRCA2, mismatch repair) were on the ACMG Secondary Findings 2.0 list. CONCLUSION In two cohorts of patients with RMS, we identified pathogenic germline variants for which gene-specific therapies and surveillance guidelines may be beneficial. In families with a proband with an RMS-risk P/LP variant, genetic counseling and cascade testing should be considered, especially for ACMG Secondary Findings genes and/or with gene-specific surveillance guidelines.
Formulation and Evaluation of Ezetimibe Nanoparticles

The aim of this study is to formulate and evaluate ezetimibe nanoparticles using solvent antisolvent technology. Ezetimibe is a practically water-insoluble drug which acts as a lipid lowering drug that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. Ezetimibe prepared as nano particles in order to improve its solubility and dissolution rate. Thirty formulas were prepared and different stabilizing agents were used with different concentrations such as poly vinyl pyrrolidone (PVPK-30), poly vinyl alcohol (PVA), hydroxy propyl methyl cellulose E5 (HPMC), and poloxamer. The ratios of drug to stabilizers used to prepare the nanoparticles were 1: 2, 1:3 and 1:4. The prepared nanoparticles were evaluated for particle size, entrapment efficiency, dissolution study, Fourier transform infrared spectroscopy, differential scanning calorimetry, and atomic force microscopy. The percentage of drug entrapment efficiency of F1-F30 was ranged from 85% Â± 1 to 98 % Â± 1. On the other hand dissolution rate increasing as the particle surface area is increase due to reduction of particle size to the nano range. The results showed that poly vinyl pyrrolidone (PVPK-30) was found to be the best stabilizer. Keywords: Ezetimibe, Nanoparticles, Particle Size, poly vinyl alcohol.
Reactions of nitroxide radicals in aqueous solutions exposed to non-thermal plasma: limitations of spin trapping of the plasma induced species

Low temperature (‘cold’) atmospheric pressure plasmas have gained much attention in recent years due to their biomedical effects achieved through the interactions of plasma-induced species with the biological substrate. Monitoring of the radical species in an aqueous biological milieu is usually performed via electron paramagnetic resonance (EPR) spectroscopy using various nitrone spin traps, which form persistent radical adducts with the short-lived radicals. However, the stability of these nitroxide radical adducts in the plasma-specific environment is not well known. In this work, chemical transformations of nitroxide radicals in aqueous solutions using a model nitroxide 4-oxo-TEMPO were studied using EPR and LC-MS. The kinetics of the nitroxide decay when the solution was exposed to plasma were assessed, and the reactive pathways proposed. The use of different scavengers enabled identification of the types of reactive species which cause the decay, indicating the predominant nitroxide group reduction in oxygen-free plasmas. The 2H adduct of the PBN spin trap (PBN-D) was shown to decay similarly to the model molecule 4-oxo-TEMPO. The decay of the spin adducts in plasma-treated solutions must be considered to avoid rendering the spin trapping results unreliable. In particular, the selectivity of the decay indicated the limitations of the PTIO/PTI nitroxide system in the detection of nitric oxide.
Effect of sowing time and density for vegetative and reproductive traits of genotypes of maize landrace in an agroecological system

ABSTRACT: Family farmers preserve the tradition of cultivating maize landrace varieties because these plants have characteristics that hybrids lack. The greatest challenge in conserving in situ on-farm genetic diversity is avoiding gene flow and genetic introgression of transgenes to landrace varieties. Thus, farmers are obliged to change sowing times to guarantee temporal isolation since most farms are small, making spatial isolation impossible. The objective of the present work was to evaluate the behavior of maize landrace varieties submitted to different sowing times and densities in an agroecological system. The test was conducted in sub-sub-divided plots, where the main plot was represented by the sowing time, the sub-plot by the genotype, and the sub-sub-plot by the density, with three replications, for two consecutive years. The results demonstrate the effect of sowing time and density on the characteristics evaluated. In western Santa Catarina, the best time to sow seeds of maize landrace varieties in an agroecological system is in September, which is when the varieties expressed the greatest potential at densities from 45,000 to 50,000 pl.ha-1 , but it will not avoid transgene contamination.
Behavior Analysis of Corona Virus Disease (Covid-19) Transmission Prevention With Health Belief Model Approach

Covid-19 is a global pandemic and the tally keep on going up all across the world. The high prevalence or incidence of Covid-19 cases is of course related to individual perceptions of the disease which will shape the practice of Covid-19 transmission preventingin accordance with recommendations. This study aims to determine the Covif-19 transmission prevention behavior among students of the Medical Study Program FK Unimal class of 2017 based on the Health Belief Model application. This research was a descriptive analytic study, using cross sectional method with a total sampling of 86. The results of the study were presented as univkeepariate descriptive analysis and bivariate analysis using the chi square test. The results showed that 77% of respondents were female, 31% lived in green zone areas, 65.1% of respondents had Covid-19 prevention behavior in the fairly good category. Perceptions of vulnerability were mostly in the fairly good category with good enough behavior as many as 41 respondents (70.7%), the most perceived severity was in the fairly good category with good enough behavior as many as 34 respondents (66.7%). Fair category with good enough behavior, namely 52 respondents (75.4%), the most perceived benefits in the fairly good category with good enough behavior were 30 respondents (76.9%), perception cues to act obtained good perceptions with good enough behavior, namely 28 respondents (59.6%) and the perception was quite good with good enough behavior were 28 respondents (71.8%). The results of the bivariate analysis showed that perceived barrier factor had significant relationship with Covid-19 prevention behavior (p = 0.000).
Performance, Serum Biochemical Profile, Slaughter Characteristics and Nutrient Retention of Vanaraja Chicks Fed Rice-based Distillers Dried Grains with Solubles in Diet

Background: In view of the increasing price of soybean meal, it has become necessary to use alternate protein sources in poultry diets. The feeding value of Rice-based DDGS (r-DDGS) was evaluated in the diet of Vanaraja chicks during the nursery phase of rearing.Methods: Two types of rice-based distillers dried grains with solubles (r-DDGS) having high (57%) and medium (47%) crude protein (CP) contents were evaluated separately at 5 and 10% levels in the diet of Vanaraja chicks on isocaloric and isonitrogenous basis and compared with the control diet without r-DDGS. A total of 300 Vanaraja chicks were divided at random into 5 experimental groups with 10 replicates of 6 chicks each and fed the diets during 0 to 6 weeks of life. Result: The body weight at 6 weeks was significantly (P less than 0.05) higher at the 5% level of r-DDGS and at the further higher level of 10% r-DDGS, the body weight, however, was similar to that of control. Feed intake was higher in the groups fed r-DDGS, whereas feed conversion efficiency was poor at the higher level of r-DDGS. Serum protein and cholesterol concentration, DM digestibility, protein retention, carcass yields and organ weights were not affected, except for the reduced weight of intestine in the groups fed r-DDGS. No significant differences were observed between the two types of r-DDGS for their effects on the variables studied. It is concluded that r-DDGS could be fed to Vanaraja chicks up to 10% in the diet without affecting growth performance, while beneficial effects on performance were noted at the lower level of 5% r-DDGS in the diet.
Removal of Anionic Dyes from Aqueous Solutions by Cellulose-Based Adsorbents: Equilibrium, Kinetics, and Thermodynamics

A novel cellulose (CE)-based adsorbent was synthesized by polyacrylamide grafted quaternized cellulose (PAM-g-QC) to remove anionic dyes. The elemental analysis results showed that there were abundant amino groups on adsorbents and scanning electron microscopy indicated the structure was porous—properties that were a benefit to increase the adsorption ability. The adsorption ability was specifically investigated in different temperatures. Adsorption isotherms including the Langmuir, Freundlich, and Temkin isotherm models were studied at different temperatures (303–323 K), and the maximum theoretical adsorption capacity of the adsorbents was 380.084 mg g–1 for Congo red (CR) and 349.284 mg g–1 for Eriochrome blue SE (EBSE) at 323 K by the Langmuir isotherm model. The adsorption data was fitted to the adsorption kinetics (pseudo-first-order kinetic, pseudo-second-order kinetic, and intraparticle diffusion models), and the pseudo-second-order kinetic model showed a better fit for the adsorption of CR and EBS.
The Impact of Agglomeration on Flavor and Flavor Stability of Whey Proteins

ZEVCHAK, SARAH E. Impact of Agglomeration on Flavor and Flavor Stability of Whey Proteins. (Under the direction of Dr. MaryAnne Drake.) Descriptive sensory analysis of freshly produced WPC80 and WPI has documented a variety of flavors in these products including sweet aromatic, cardboard/wet paper, pasta water, brothy, cucumber, and soapy flavors, astringent mouthfeel and bitter taste. Concurrent volatile analysis has revealed an array of heatinduced and lipid and protein oxidation compounds. The purported shelf life of WPC80 and WPI varies from 12 to 18 months depending on the supplier. However, to our knowledge, no studies have addressed stability of WPC80 or WPI or the impact of agglomeration on the flavor and flavor stability of WPC80 and WPI. In this study, agglomerated (re-wet and single pass) and non-agglomerated samples of WPC80 and WPI from different facilities were analyzed for flavor and selected physical properties over the course of fifteen months. Descriptive sensory analysis and volatile analysis were conducted every 2 months. Samples were tested every six months for solubility, bulk volume, dispersibility, moisture, and color (L,a,b). Proximate analysis was conducted at time zero. Consumer acceptance tests were conducted on representative samples after 0, 6, 9, 12 and 15 months storage using vanilla protein shakes and peach flavored beverages with WPC80 and fruit flavored clear acidified beverages with WPI. Agglomerated powders displayed higher bulk volume and dispersibility than their non-agglomerated counterparts. Solubility, bulk volume, dispersibility, moisture and color did not significantly change with storage time. Higher intensities of lipid oxidation flavors (cardboard, raisin/brothy, cucumber, and fatty) were noted in agglomerated powders compared to control powders (p<0.05). Sensory results were confirmed by volatile analysis results which showed increased formation of aldehydes and ketones in agglomerated products compared to control powders (p<0.05). Acceptance tests with protein beverages revealed few differences in consumer acceptance between agglomerated and non-agglomerated whey proteins or between fresh versus stored whey proteins although trained panelists documented consistent differences. Agglomeration or agglomeration with lecithin decreased the storage stability of whey proteins. These results indicate that the optimum shelf life at 21C for non-agglomerated powders is between 12-15 months and 8-10 months for agglomerated powders. The Impact of Agglomeration on Flavor and Flavor Stability of Whey Proteins
Sublingual immunotherapy in mite-sensitized patients with atopic dermatitis: a randomized controlled study

Introduction Sublingual immunotherapy (SLIT) has been shown to be efficacious in patients with airway allergic diseases. However, less data have been demonstrated to show the efficacy of SLIT in patients with atopic dermatitis (AD). Aim This study is to evaluate, in a randomized controlled study, the effect of SLIT with house dust mite (HDM) in patients with mild–moderate AD. Material and methods AD patients aged 4 to 60 years with a Scoring Atopic Dermatitis (SCORAD) score of 7–40 and sensitization to HDM were enrolled in the study. SLIT or control treatment was given for 24 months. SCORAD, visual analog scale (VAS) score were recorded at 6, 12, 24 month, and rescue medications were required to be recorded in the diary card. A serum level of specific IgE was tested at 24-month treatment. Results Ninety-six patients were enrolled, and forty-eight were allocated to SLIT. Thirty-nine patients in the SLIT group and thirty-eight patients in the control group completed the study. The patients in the SLIT group had significantly decreased ΔSCORAD, VAS and rescue medication score from 12 months’ treatment compared with the control group (p < 0.05). At 24 months of treatment, no significant change of specific IgE (p < 0.05) was observed in both groups. No severe adverse events were reported during the treatment. Conclusions Two years’ SLIT to HDM significantly improved the clinical symptoms and reduced drug use in patients with mild–moderate AD. SLIT may represent an additional therapeutic tool for the treatment of AD in properly selected patients.
Chernobyl Cancer Studies with Overseas Control: High Grade vs. Late Detection

This is an addition to the review published in the Turkish Journal of Pathology (1), commenting on the series of studies (2-7), in particular, the last one making a comparison of clear-cell renal carcinoma (RC) tissue specimens from Ukraine with those from Colombia and Spain (7). Thyroid cancer (TC) is discussed by analogy. RCs from Ukraine tended to be higher-grade than those from Spain and Colombia (2-7); among others, they displayed a sarcomatoid i.e. poorly differentiated pattern more frequently: 62 from 236 (26.3%) of Ukrainian vs. 11 from 112 (9.8%) of Spanish cases (p<0.001) (2). The statistically significant difference was confirmed in the later work (4). In the recent study, the microvessel density in RC tissue from patients residing both in “highly” and “low contaminated areas of Ukraine” (7) was higher than that in RC from Spain and Colombia (p<0.01). The difference between the two Ukrainian groups was statistically insignificant. The increased angiogenesis was associated with a higher expression of VEGF (7). It was assumed that the exposure to ionizing radiation leads to an increase in the microvessel density, which in turn is associated with a higher grade of RC (6,7). In this connection, the following citations should be commented: “The dramatic increase of aggressivity and proliferative activity” was found in RC from Ukraine, while “the majority of the high grade tumors occurred in the Ukrainian (rather than in the Spanish) groups” (2). These differences can be explained by the earlier cancer detection on average in Spain and discovery by the screening of advanced cases in Ukraine (8).