Miracle-dz/UniFAR-FTUs huggingface dataset:
Probing Surface Information of Alloy by Time of Flight-Secondary Ion Mass Spectrometer

In recent years, time of flight-secondary ion mass spectrometer (ToF-SIMS) has been widely employed to acquire surface information of materials. Here, we investigated the alloy surface by combining the mass spectra and 2D mapping images of ToF-SIMS. We found by surprise that these two results seem to be inconsistent with each other. Therefore, other surface characteristic tools such as SEM-EDS were further used to provide additional supports. The results indicated that such differences may originate from the variance of secondary ion yields, which might be affected by crystal orientation.
DUCTILITY DEMANDS CONTROL UNDER REPEATED EARTHQUAKES USING APPROPRIATE FORCE REDUCTION FACTORS

This paper develops a new procedure for the ductility demands control of single-degree-of freedom (SDOF) systems under multiple earthquakes. According to the proposed method, this objective can be achieved using appropriate force reduction (R) factors. In this way, the total ductility demands, and therefore the cumulative damage levels, are absolutely controlled. The influence of structural period, local site conditions, post-yield stiffness, and viscous damping is taken into account. In order to achieve a unique, simple, and effective empirical expression for the R factors, a comprehensive nonlinear regression analysis is applied. Thus, a complete statistical investigation of 3,360,000 inelastic time-history analyses are carried out to study 8400 SDOF models excited by 100 earthquake accelerogram records, under 4 cases of seismic sequence. It is found that multiple earthquakes require increased ductility demands and repeated frequent or smaller ground motions necessitate equal or smaller force reduction factors in comparison with the idealized or isolated "design earthquake. " Therefore, the multiplicity of earthquakes leads to more conservative force reduction factors in comparison with the "design earthquake. "
Trends of Esophageal Cancer Incidence and Mortality and Its Influencing Factors in China

Purpose To explore the esophageal cancer (EC) incidence and mortality trends and risk factors in China during 2005–2015. Materials and Methods The data were stratified by area (urban, rural), gender (male, female), and age groups (0 ~, 5 ~, …, 85 ~). The age-standardized incidence rate (ASIR) and mortality rate (ASMR), age-specific incidence and mortality were calculated to describe the trends, which were analyzed by Joinpoint software, negative binomial regression model, and age-period-cohort model. Results Trends in EC ASIR decreased markedly during 2010–2015 (APC=−6.14%, P<0.05), and the average annual percent change (AAPC) value was −8.07% (95% confidence interval (CI): −9.98~−6.12) for rural areas during 2005–2015. The ASMR was on a fast-downward trend after 2011 (APC=−6.67%, P<0.05), with AAPC values of −1.34% (95% CI: −2.56~−0.19) for males, −3.39% (95% CI: −5.65, −1.07) for females, and −9.67% (95% CI: −10.56~−8.77) for rural areas during 2005–2015. The age-specific incidence and mortality increased with age. The risk of EC for males was 3.1675 times higher than females (P<0.001), and for urban areas, it was 0.58 times larger than rural (P<0.001). The age and period effects presented an increasing trend, with a decreasing trend for the cohort effects in incidence and mortality risk. Later birth cohorts presented lower risks than previous birth cohorts. Conclusion ASIR and ASMR in China are higher in males than females, and higher in rural than urban areas, which have decreased during 2005–2015, especially in rural areas. The incidence increased with age up to the peak age group of 75. Area, gender, and age were independent risk factors for EC incidence.
Chemical characterization of an Ipecac active germplasm bank – a Brazilian endangered medicinal species

The active germplasm bank (AGB) of Carapichea ipecacuanha (Brot.) L. Andersson at Embrapa Eastern Amazon, in the city of Belém, PA, was the first of its kind to be opened in Brazil for this endangered medicinal species and holds important accessions for agricultural and reproductive research, including the production of active principles. This study aimed to chemically characterize 42 accessions from that AGB by simultaneously quantifying cephaeline and emetine contents in roots using high-performance liquid chromatography with a diode-array detector (HPLC-DAD). Cephaeline concentrations ranged from ‘undetected’ to 1.76%, whereas emetine concentrations were found between 0.64% and 2.49%. The overall emetine/cephaeline ratio varied from 0.43 to 3.52. The differences among mean concentrations of alkaloids observed by comparing the Scott-Knott test at 5% probability suggest the chemical variation among the samples assessed. Therefore, it is concluded such chemical differences may favor the selection of genetic material for commercial purposes based on the production of emetine and/or cephaeline, likewise may contribute to breeding programs.
Sensitivity of horizontal surface deformation to mantle dynamics from 3D instantaneous dynamics modeling of the eastern Mediterranean region

Geodetically estimated surface motions contain contributions to crustal deformation from coupled geodynamic processes active at all spatial scales and constitute key data for lithosphere dynamics research. Data interpretation methods should therefore account for the full range of possible processes, otherwise risking misinterpretation of data signal and incorrect estimation of lithosphere rheology, stress, or deformation fields. Here we explore the sensitivity of surface deformation to sub-lithospheric processes such as viscous plate-mantle and slab-mantle coupling, variations in slab pull, and buoyancy-driven mantle flow. To this end, we perform 3D instantaneous-dynamics numerical modelling of an elaborately structured compressible crust-mantle system designed for the Eastern Mediterranean Aegean-Anatolian region. We first determine a reference model driven by the absolute motions of the major plates, regional slab pull, a 3D mantle buoyancy field, and modulated by plate boundary coupling and mantle viscosity. The RMS motion data fit of ~5.9 mm/yr of predicted and observed Aegean-Anatolian horizontal surface motions demonstrates that the bulk amplitude of surface motion can be explained by these combined mantle processes. Next, by systematically perturbing reference model features, we assess the crustal sensitivity to each geodynamic driver and to mantle rheology. We find significant changes in crustal velocity gradient amplitudes, often between 10% and 40% of the reference model, with slab morphology effects of up to 93%. This demonstrates the key importance of carefully accounting for each process in modelling lithosphere dynamics. For the Aegean-Anatolia region, we present geodynamic evidence that the Aegean slab pull is the primary driver of the crustal motion field, as was previously suggested from kinematic analysis.
Social Capital, Resilience and Social Integration of Chinese Migrant Children

Abstract This study attempts to explore the impact of multi-dimensional social capital and resilience on migrant children’s social integration, in China so as to provide theoretical and practical implications for social policies and social work intervention toward Chinese migrant children. A total of 461 valid samples from primary schools of Guangzhou were surveyed for analysis. By running three regression models, the direct and indirect effects of family, school, and community social capital were observed. Besides, the mediation effect of the resilience was estimated. In order to confirm the mediation effect of the resilience, the Bootstrap method was used to examine the mediating effect of the resilience. The results showed resilience is the most influential factor, followed by three forms of social capital, family social capital, school social capital, community social capital. In addition, length of time living in Guangzhou, self-efficacy, the frequency of engaging in activities provided by social workers, and average monthly household income were significant factors. It is worth noting that three forms of social capitals have a direct impact on social integration, and they also affect social integration through the mediating role of the resilience. Further research can examined the causal relationship amongst the integration, social capital and resilience of migrant children by collecting longitudinal data or panel data. Moreover, future research could investigate how welfare policies and social work practice improve social integration of migrant children through effecting both their social capital and individual resilience.
Influence of Continuous Assessment in the Teaching of Mathematics in Secondary Schools in Edo State

This study examined the influence of continuous assessment in the teaching of mathematics in secondary schools in Edo State. Four research questions and hypotheses guided the study. The research employed a survey design. Seventy (70) mathematics teachers were randomly selected from a population of over (240) mathematics teachers in secondary schools in Edo State, Nigeria. A well structured likert type of questionnaire containing (20) items was employed while chi square goodness of fit was the major statistical tool used for data analysis. A co-efficient of 0.75 was obtained for the instrument using Cronbach high co-efficient reliability test. The results showed that the practice of continuous assessment has a significant relationship with students' academic performance in mathematics and also help to motivate students' in the teaching and learning of mathematics. Based on these results, conclusions and recommendations were made. Some of these are: The government should frequently organize workshops, seminars and conferences for serving mathematics teachers on the practice of continuous assessment in secondary schools. Institutions of higher learning should make continuous assessment a major course in their pre-service teachers training programme. The undergraduate education mathematics course should be widened to cover all aspects of continuous assessment.
A simple and versatile phase comparison method can accurately measure long term instability

Accurate long-term phase noise measurements are performed by a mixer, a personal computer, and a general-purpose interface. When absolute noise has to be characterized, it is possible to have measuring sessions virtually infinite in time, utilizing a simple discrete phase shifter realized by switching three coaxial cables of different lengths. Accurate phase retrievement is accomplished by antitransforming the ideal sinusoidal transfer function of the mixer, while its higher spurious responses are minimized by a careful optimization of its operating parameters. This configuration has been successfully used to estimate the Allan variances from 1 s up to 100000 s of the phase comparison of two H-maser atomic standards, for almost nine days, without the need of any frequency offset between the two sources, which were used at the same time as timekeepers. A computer simulation is also presented to predict a priori the level of inaccuracy determined by the higher-order mixer nonlinearities and the final effect of each experimental parameter. >
Phenolic Composition and Biological Properties of Cynara cardunculus L. var. altilis Petioles: Influence of the Maturity Stage

Hydroethanolic extracts of cardoon petioles collected at sixteen growth stages (P1–P16) were characterized in terms of their phenolic composition and bioactive potential (antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities). Fifteen phenolic compounds were tentatively identified (i.e., ten phenolic acids and five flavonoid glycosides); the main compounds were 5-O-caffeoylquinic and 1,5-di-O-caffeoylquinic acids. Samples collected at early maturity (P1–P4) presented a weak positive correlation between the higher content in polyphenols (P3: 101-mg/g extract) and better inhibition capacity against thiobarbituric acid reactive substance formation (TBARS; P3: IC50 = 5.0 µg/mL). Samples at intermediate maturation stages (P9) presented higher cytotoxic and anti-inflammatory potential. Moreover, immature petioles showed greater antihemolytic (OxHLIA; P4: IC50 = 65 and 180 µg/mL for Δt of 60 and 120 min, respectively) and antibacterial activity. The antifungal activity varied depending on the maturation stage and the fungi strain. In conclusion, the maturation stage may greatly affect the polyphenols composition and content and the bioactive potential of cardoon petioles.
Platelet-lymphocyte ratio and sepsis outcome in children

Background Sepsis is the most common cause of death in infants and children worldwide. Identification of patients with a high risk of death and accurately anticipating outcomes in the early phase is very important in order to provide adequate intervention to the patient. Predictors and scoring systems have been used to determine the prognosis of sepsis n children. The platelet-lymphocyte ratio (PLR), a newly-used marker for inflammation, has received recent attention, as it can act as an indicator in a variety of diseases, including sepsis. Objective o investigate the relationship between PLR and clinical outcomes in pediatric patients with sepsis. Methods This study was conducted using an analytic, observational method with a prospective cohort approach in children with sepsis in the Pediatric Intensive Care Unit (PICU) of Prof. Dr. R. D. Kandou Central General Hospital, Manado, North Sulawesi, from February to August 2020. We analyzed patients’ platelet-lymphocyteratio (PLR), mortality rate, and length of stay using SPSS software. The PLR were recorded once within the first 24 hours of PICU admission. Results Of 96 PICU patients, 87 patients were eligible for this study. In total, 50 patients (57.47%) died. Mean PLR was 77.53 among sepsis survivors and 157.2 among non-survivors (rpb=0.566, P<0.0001) indicating a strong relationship between PLR and mortality. We also found a strong positive linear relationship between PLR and PICU length of stay. Conclusion Platelet-lymphocyte ratio is a predictor of sepsis outcomes that can be easily and inexpensively checked. Thus, it can be used in regions with limited health facilities.
Two new species of Diaporthe (Diaporthaceae, Diaporthales) associated with tree cankers in ﻿the Netherlands

Abstract Diaporthe (Diaporthaceae, Diaporthales) is a common fungal genus inhabiting plant tissues as endophytes, pathogens and saprobes. Some species are reported from tree branches associated with canker diseases. In the present study, Diaporthe samples were collected from Alnusglutinosa, Fraxinusexcelsior and Quercusrobur in Utrecht, the Netherlands. They were identified to species based on a polyphasic approach including morphology, pure culture characters, and phylogenetic analyses of a combined matrix of partial ITS, cal, his3, tef1 and tub2 gene regions. As a result, four species (viz. ﻿﻿Diaporthepseudoalnea sp. nov. from Alnusglutinosa, Diaporthesilvicola sp. nov. from Fraxinusexcelsior, D.foeniculacea and D.rudis from Quercusrobur) were revealed from tree branches in the Netherlands. Diaporthepseudoalnea differs from D.eres (syn. D.alnea) by its longer conidiophores. Diaporthesilvicola is distinguished from D.fraxinicola and D.fraxini-angustifoliae by larger alpha conidia.
A RATIONAL APPROACH TO SEPTIC TANK DESIGN

A new approach to the design of septic tanks was developed based on a number of critical parameters, namely: residual detention time, minimum residual detention time, residual depth and minimum residual depth. This method involved rst specifying a desired desludging interval. This interval was then substituted in a septage accumulation model to obtain the volume of sludge accumulated in this time interval. Using a minimum detention time of 24 hours and a desired minimum residual depth, the plan area of the tank was then determined and hence, the depth of sludge volume. The total depth of the tank was obtained as the sum of the sludge depth, residual depth and depth of reserve space. The length and width of the tank were also obtained from the plan area by using a length to width ratio (L/W) ranging between 2 to 4 or any other range depending on land conguration. Design charts and a Microsoft Excel based design programme were produced to aid the design of septic tanks. A predetermined desludging interval ensures septic tanks are effcient and durable.
miRNA-425-5p enhances diffuse large B cell lymphoma growth by targeting PTEN

Background At present, cancer is one of the greatest threats to mankind, and is associated with the highest rates of morbidity and comorbidity. Recently, the advancements in molecular biology have led to an in-depth understanding of the underlying pathophysiology, which may further impact the lead time in the context of early discovery and effective therapy of cancer. Therefore, the present study proposes a better understanding of the role of micro(miR)-425-5p in diffuse large B-cell lymphoma (DLBC). Methods qRT-PCR was carried out to detect the relevant proteins, miRNA and mRNA RNA gene expression in DLBC cells. The effect of miR-425-5p on DLBC growth was examined by CCK-8 and colony formation assays. The binding relationship between genes was verified by dual-luciferase reporter gene assay. Results We demonstrated how the over-expression of miR-425-5p can lead to increased progression of DLBC by increasing the cellular proliferation rate and colony-forming ability. Additionally, we also found that the expression of miR-425-5p could be significantly inhibited on the basis of phosphatase and tensin homolog (PTEN) signaling pathways. Conclusions The present study concludes that miR-425-5p is responsible for the oncogenic progression and relapse of DLBC tumorigenesis via PTEN/PI3K signaling, which can thus be effectively used to achieve better therapeutic outcomes.
Highly Miniaturized Self-Diplexed U-Shaped Slot Antenna Based on Shielded QMSIW

This article presents an efficient yet simple design approach to highly miniaturized cavity-backed self-diplexing antenna (SDA) with high-isolation. The structure employs a shielded quarter-mode substrate integrated waveguide (QMSIW). Two U-shaped slots are engraved on the top conducting plane, which realize two frequency bands and significant size reduction. The slots are excited by two independent 50Ω orthogonal feed-lines to achieve high isolation while enabling radiation at 3.5 GHz and 5.4 GHz. The proposed design approach allows us to design the two frequency bands independently from each other. The SDA structure is verified using an equivalent circuit model, full-wave electromagnetic (EM) analysis, and experimental validation of the antenna prototype. Excellent consistency between simulated and measured responses has been demonstrated. According to the measurement, the SDA has peak gains of 5.26/5.60 dBi at 3.5/5.4 GHz, and the return loss better than 21.6 dB. The isolation between ports is greater than 40 dB, whereas excellent front-to-back-ratio and co-to-cross polarization are obtained for the proposed SDA. Furthermore, the total size of the SDA is only 0.129 λ2, with λ being the guided wavelength at 3.5 GHz.
Design theory of dielectric-coated circular metallic waveguides for infrared transmission

A circular metallic hollow waveguide with inner dielectric multilayers is designed with the emphasis on low-loss transmission of the HE 11 mode for the infrared. The effects of absorptions and variations of thickness of coated dielectric materials are discussed and are shown to be small on the minimum attainable transmission losses. Mode structure and transmission properties are also clarified for the general class of hollow waveguides by using a normalized surface impedance and admittance.
Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents

ABSTRACT The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Children and Adolescents was developed by dietitians, physicians, and pediatric hematologists from 10 Brazilian reference centers in hematopoietic stem cell transplantation. The aim was to emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to patient´s nutritional assessment. This consensus is intended to improve and standardize nutrition therapy during hematopoietic stem cell transplantation. The consensus was approved by the Brazilian Society of Bone Marrow Transplantation.
Digital Twin for Industrial Robotics

: This thesis aims to develop a Digital Twin model for robot programming that incorporates Virtual Reality (VR). The digital twin is a concept of creating a digital replica of a physical object (such as a robot), which is similar to establishing a model simulation along with some additional functionalities. Simulation software, such as robot operating system (ROS) or other industrial-owned simulation platforms, simulates a robot operation and sends the details to the robot controller. In contrast to this, the Digital Twin model establishes a two-way communication channel between the digital and the physical models. In this thesis, the proposed Digital Twin model can help in online/remote programming of a robotic cell with high accuracy by creating a 3D digital environment of a real-world physical setup, which is similar to watching a movie with 3D glasses. To create a Digital Twin model, the gaming platform is used that comes with specialized plugins for virtual and augmented reality devices. One of the main challenges in any robotic system is writing a code for a deﬁned path and modifying it for future requirements. Programming robot via this traditional approach requires a lot of time and often disturbs the running process. Whereas, in the case of a Digital Twin model, the program can be adjusted or regenerated without disturbing the execution cycle of a physical robot. In this work, I have considered the FANUC robot model M-10iA/12 and created a 3D virtual environment using a gaming engine (Unity), that describes a complete Digital Twin model. After establishing a Digital Twin, we can see the motion replica in a physical robot with beneﬁts of VR environment, where we can see more precise details of the trajectory w.r. t to the working components. The simulation analysis gives the latency of approximately 40ms (milliseconds) with a mean error of joint movements is around 0.28°. Based on the results, it can be concluded that the model developed under this thesis is suitable for industrial applications.
PALM GAMMA-TOCOTRIENOL SUPPLEMENTATION SUPPRESS TUMOUR GROWTH AND METASTASIS IN A SYNGENEIC MOUSE MODEL OF BREAST CANCER

Gamma-tocotrienol (γT3) is an isoform of vitamin E found abundantly in palm oil, which is reported to possess antioxidant and anticancer activities. However, the immune-modulating properties of γT3 have yet to be elucidated. Breast cancer (BC) was induced in female BALB/c mice by injecting 4T1 murine mammary cancer cells into their mammary fat pads. When the tumour was palpable, the animals were randomly assigned into two groups: (i) control [fed twice daily with 50 μL vehicle (soy oil)] or (ii) experimental (fed twice daily with 50 μL of 0.5 mg of γT3). Results show that mice fed with γT3 had reduced tumour growth and metastasis. However, there are no marked changes in the percentages of peripheral blood leukocytes and cytokines production in these animals. Immunohistochemistry using antibodies to murine CD4, IL12Rβ2, IL24 and FoxP3 on tumour sections from γT3 treated mice suggested that γT3 induced suppression of tumour growth and metastasis as well as reduced immunosuppression in the tumour microenvironment. It can be concluded that, γT3 has the potential to suppress tumour growth and metastasis in this model. Further investigation on the host immune response is possible by prolonging treatment duration against BC.