Miracle-dz/UniFAR-FTUs huggingface dataset:
Generalizing Andreev's Theorem via circle patterns

In this paper we derive an extended Circle Pattern Theorem that allows obtuse overlap angles. As a consequence, we characterize a subclass of compact convex hyperbolic polyhedra with possibly obtuse dihedral angles and thus generalize Andreev's Theorem. For proofs of these results, we establish a discrete analog of the"weak solution/regularity theory"scheme.
Enhancing Landmark Detection in Cluttered Real-World Scenarios with Vision Transformers

Visual place recognition tasks often encounter significant challenges in landmark detection due to the presence of irrelevant objects such as humans, cars, and trees, despite the remarkable progress achieved by previous models, especially in the context of transformers. To address this issue, we propose a novel method that effectively leverages the strengths of vision transformers. By employing a meticulous selection process, our approach identifies and isolates specific patches within the image that correspond to occluding objects. To evaluate the efficacy of our method, we created augmented datasets and conducted comprehensive testing. The results demonstrate the superior accuracy achieved by our proposed approach. This research contributes to the advancement of landmark detection in visual place recognition and shows the potential of leveraging vision transformers to overcome challenges posed by cluttered real-world scenarios.
Aggressive NK-Cell Leukemia

Aggressive NK cell leukemia (ANKL) is a rare malignant lymphoproliferative disorder of mature NK cells closely associated with Epstein-Barr virus (EBV) and more common in East Asia than in other areas. Significant variations exist in the morphology of ANKL tumor cells, from typical large granular lymphocyte morphology to highly atypical features with basophilic cytoplasm containing azurophilc granules. The main involved sites are hepatosplenic lesions, bone marrow and peripheral blood, and nasal or skin lesions are infrequent. A fever and liver dysfunction with an often rapidly progressive course are the main clinical symptoms, including hemophagocytic syndrome and disseminated intravascular coagulation. Although the outcome had been dismal for decades, with a median survival of less than three months, the introduction of combined chemotherapy including L-asparaginase and allogeneic hematopoietic cell transplantation has helped achieve a complete response and potential cure for some patients. With the advent of next-generation sequencing technologies, molecular alterations of ANKL have been elucidated, and dysfunctions in several signaling pathways, including the JAK/STAT pathway, have been identified. Novel target approaches to managing these abnormalities might help improve the prognosis of patients with ANKL.
Site-selective formation of an iron(IV)-oxo species at the more electron-rich iron atom of heteroleptic -nitrido diiron phthalocyanines

Please note that technical editing may introduce minor changes to the text and/or graphics, which may alter content. The journal’s standard Terms & Conditions and the Ethical guidelines still apply. In no event shall the Royal Society of Chemistry be held responsible for any errors or omissions in this Accepted Manuscript or any consequences arising from the use of any information it contains. Accepted Manuscript Chemical Science
Ecology of Fresh Waters: Man and Medium

The Pongolo floodplain on living in water from atmosphere to stream - the chemical birth of freshwater upland streams and rivers lowland rivers and their floodplains lakes, pools and other standing waters - some basic features of their productivity the plankton and fish communities of the open water the edges and bottoms of lakes and their communities fish production and fisheries in lakes the birth, development and passing of lakes.
A Comparison of Direct and Iterated Multistep Ar Methods for Forecasting Macroeconomic Time Series

‘Iterated’ multiperiod ahead time series forecasts are made using a one-period ahead model, iterated forward for the desired number of periods, whereas ‘direct’ forecasts are made using a horizon-specific estimated model, where the dependent variable is the multi-period ahead value being forecasted. Which approach is better is an empirical matter: in theory, iterated forecasts are more efficient if correctly specified, but direct forecasts are more robust to model misspecification. This paper compares empirical iterated and direct forecasts from linear univariate and bivariate models by applying simulated out-of-sample methods to 171 US monthly macroeconomic time series spanning 1959-2002. The iterated forecasts typically outperform the direct forecasts, particularly if the models can select long lag specifications. The relative performance of the iterated forecasts improves with the forecast horizon.
Explaining the lithium ISM decrease at super-solar metallicities in the Solar vicinity

We propose here that the lithium decrease at super-solar metallicities observed in high resolution spectroscopic surveys can be explained by the interplay of mixed populations, coming from the inner regions of the Milky Way disc. The lower lithium content of these stars is a consequence of inside-out disc formation, plus radial migration. In this framework, local stars with super-solar metallicities would have migrated to the solar vicinity and depleted their original lithium during their travel time. To arrive to such a result, we took advantage of the AMBRE catalog of lithium abundances combined with chemical evolution models which take into account the contribution to the lithium enrichment by different nucleosynthetic sources. A large proportion of migrated stars can explain the observed lower lithium abundance at super-solar metallicities. We stress that nowadays, there is no stellar model able to predict Li-depletion for such super-solar metallicity stars, and the Solar Li-depletion has to be assumed. In addition, it currently exists no solid quantitative estimate of the proportion of migrated stars in the Solar neighborhood and their travel time. Our results illustrate how important it is to properly include radial migration when comparing chemical evolution models to observations, and that in this case, the lithium decrease at larger metallicities does not necessarily imply that stellar yields have to be modified, contrary to previous claims in literature.
Nuclear Peroxisome Proliferator-Activated Receptors a and g Have Opposing Effects on Monocyte Chemotaxis in Endometriosis

The peroxisome proliferator-activated receptors (PPARs) a and g are nuclear receptors that play important roles in inflammatory diseases like ulcerative colitis and arthritis. In this study, we examined the possible role of PPARs in macrophage attraction into the peritoneal cavity of patients with endometriosis. We identified PPAR-a and -g messenger RNA by RT-PCR and protein by immunoblotting of lysates of peritoneal macrophages and monocytic U937 cells. Using immunocytochemistry, we localized PPAR-a and -g within the nuclei of both cell types. Monocyte chemotactic activity of peritoneal fluid from patients with endometriosis was quantified in Boyden chambers. Migration of U937 cells was increased by WY 14643 and reduced by rosiglitazone. Peritoneal fluid from patients with endometriosis activated U937 cells transiently transfected with a PPAR-a/GAL4 luciferase reporter. By contrast, peritoneal fluid did not cause significant activation of PPAR-g/GAL4 constructs. The U937 cells transiently transfected with a PPAR response element luciferase reporter showed disease stage-dependent up-regulation when treated with peritoneal fluid from patients with endometriosis. Treatment with peritoneal fluid from healthy controls down-regulated PPAR response element transactivation. We conclude that peritoneal fluid of endometriosis patients contains activators of PPAR-a that stimulate macrophage chemotaxis. Inhibitors of PPAR-a or activators of PPAR-g could be developed for the treatment of inflammation associated with endometriosis. (J Clin Endocrinol Metab 86: 3108–3114, 2001) O THE PAST two decades, considerable evidence for a cell-mediated immunological etiology of endometriosis has accumulated. Resident leukocytes within endometriotic implants have been identified histologically (1–3). Furthermore, increased numbers of peritoneal leukocytes are found in women with endometriosis (4–6). Of these, the most numerous are the macrophages, and these cells manifest an activated phenotype in women with laparoscopic evidence of endometriosis (7–9). It has been proposed that the cytokines elaborated from activated peritoneal macrophages mediate many of the symptoms associated with the endometriosis syndrome (10). The attraction of inflammatory cells into the peritoneal cavity has been a major focus of our laboratory over the past decade. Shortly following the cloning and characterization of RANTES, a monocyte and T-cell chemokine (11), we reported its detection in peritoneal fluid from women with advanced stages of endometriosis (6). Indeed, a variety of chemokines have been identified in human peritoneal fluid. Most of these predominantly recruit monocytes [e.g. RANTES (6)], monocyte chemotactic protein-1 (12), and vascular endothelial growth factor (13, 14); however chemoattractants for neutrophils [e.g. interleukin-8 (15)], epithelial neutrophil-activating protein-78 (16)), and eosinophils [eotaxin (17)] also
Use of Remotely Sensed Data to Quantify Plant Water Use from Irrigated Lands in Wolf Bay Watershed Area

ii Acknowledgments iv List of Tables viii List of Figures x Chapter 1: Introduction 1 1.1 Background 1 1.2 Problem Justification 8 1.3 Research Objectives 10 1.4 Thesis Outline 11 Chapter 2: Literature Review: Remote Sensing Method for Quantifying Plant Water Use . 12 2.1 Plant Water Use and Evapotranspiration 12 2.2 Evapotranspiration Estimation Methods 13 2.3 Remote Sensing Methods of Estimating Evapotranspiration 16 2.4 Surface Energy Balance Algorithm for Land (SEBAL) 18 2.5 Identification of Irrigated Lands 21 2.6 Water Demand Factor 22 2.7 Summary of Literature Review 25 Chapter 3: Validation of a Modified Surface Energy Balance Algorithm Model in Florida . 27 Abstract 27
Histopathological Significance and Prognostic Impact of Tumor Budding in Colorectal Cancer

Background. Colorectal cancer (CRC) is a heterogeneous disease with complex etiology. New prognostic factors for this group of disease need to be investigated. This study evaluated the histopathological significance and prognostic impact of tumor budding in CRC. Design. A total of 60 treatment naive consecutive patients undergoing surgical resection for CRC during the period of January 2011 to December 2013 were included in the study. Details of each patient related to their demographic and tumor profile were recorded. Pan Cytokeratin immunohistochemistry was applied on chosen sections and tumor budding was assessed. Results. The most frequent site of involvement was rectosigmoid and sigmoid colon (31.6%). The majority of the cases were moderately differentiated (75%) in morphology, and showed tumor invasion into the pericolic/subserosal fat (66.6%), and were stage III (38.3%). Nodal involvement was present in 50% cases. Correlations between tumor budding and nodal involvement (p‐value 0.039) and AJCC stage (p‐value 0.021) were found to be statistically significant. Conclusion. Tumor budding may be a promising and powerful predictor of lymphnodal metastasis and a higher stage of tumor and can be used as a marker for assessing the aggressiveness of CRC. Routine hemotoxylin‐eosin staining supported by cytokeratin immunostain can aid in the grading of tumor budding in CRC.
Peripapillary microvasculature in the retinal nerve fiber layer in glaucoma by optical coherence tomography angiography: focal structural and functional correlations and diagnostic performance

Purpose: To quantify peripapillary microvasculature within the retinal nerve fiber layer (RNFL) in primary open-angle glaucoma (POAG) and normal eyes, determine association of perfusion parameters with structural and functional measures, and report diagnostic accuracy of perfusion parameters. Patients and methods: POAG and normal patients underwent 6 × 6 mm 2 optic nerve head scans were most significant. OCTA parameters had stronger associations with structural rather than functional measures of glaucoma. subspecialties within ophthalmology. Key include: Optometry; Visual science; Pharmacology and drug therapy in eye diseases; Basic Sciences; Primary and Secondary eye care; Patient Safety and Quality of Care Improvements.
Control of Oocyte Reawakening by Kit

In mammals, females are born with finite numbers of oocytes stockpiled as primordial follicles. Oocytes are “reawakened” via an ovarian-intrinsic process that initiates their growth. The forkhead transcription factor Foxo3 controls reawakening downstream of PI3K-AKT signaling. However, the identity of the presumptive upstream cell surface receptor controlling the PI3K-AKT-Foxo3 axis has been questioned. Here we show that the receptor tyrosine kinase Kit controls reawakening. Oocyte-specific expression of a novel constitutively-active KitD818V allele resulted in female sterility and ovarian failure due to global oocyte reawakening. To confirm this result, we engineered a novel loss-of-function allele, KitL. Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 protein localization in the nucleus versus cytoplasm explained both mutant phenotypes. These genetic studies provide formal genetic proof that Kit controls oocyte reawakening, focusing future investigations into the causes of primary ovarian insufficiency and ovarian aging.
Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. (I2-2B)

Objective: We hypothesize that CCM3 cases have unique phenotypic features not recognized in the more common CCM1 and 2 families, or in sporadic cases. Background: Familial forms of cerebral cavernous malformations (CCM) account for about 1/3 of cases, involving autosomal dominant inheritance at 1 of 3 gene loci. Few studies have examined any special features of the rarest cases with CCM3 (PDCD10) mutation at q3. Design/Methods: Thirteen probands including 18 subjects with confirmed CCM3 mutations were prospectively enrolled through systematic facilitated referral by the patient advocacy group Angioma Alliance. Clinical features were catalogued, including high sensitivity susceptibility weighted imaging (SWI). Rates of overt hemorrhage were determined based on adjudicated criteria. Comparisons were made to systematic literature review of natural history data on non-CCM3 cases. Results: The first overt hemorrhage occurred most often in the 1st decade of life (mean age 5.9) significantly younger when compared to our non-CCM3 cases. The rate of symptomatic hemorrhage is 7.9 [percnt] /patient/year based on exposure risk since birth, and 20[percnt] /patient/year based on risk since first symptom onset. Lesion burden on SWI was exceptionally high, >100 lesions in 33[percnt]. Age adjusted SWI lesion burden is 2 SWI lesions/year of life in CCM3 versus 1.1 lesion/year of life in the non-CCM3. New SWI lesions formed at a rate of 2.4/patient/year in prospective follow-up. Scoliosis was found in 39[percnt] (an association not recognized previously), skin lesions in 28[percnt], and brain tumors in 28[percnt] of cases. Cognitive disability affected 61[percnt] of cases. Six of 15 cases with parental screening (40[percnt]) represented a spontaneous mutation. Conclusions: CCM3 is exceptionally aggressive compared to other familial and sporadic CCM. The exceptionally high rate of lesion formation and high risk of hemorrhage provide an opportunity to focus preclinical optimization and early therapeutic trials on this seriously affected cohort of CCM disease Disclosure: Dr. Rebeiz has nothing to disclose. Dr. Mikati has nothing to disclose. Dr. Akers has nothing to disclose. Dr. zhang has nothing to disclose. Dr. Awad has nothing to disclose.
Joint Modeling of Multivariate Longitudinal Depressive Symptoms and Survival with Application to an Aging Study

Objective The primary aim in this study was to use a joint analysis approach to examine the association between longitudinal depressive symptoms and survival in Mexican Americans. Methods: The separate Cox regression and joint modeling were applied to data from the Hispanic Established Population for Epidemiological Study of the Elderly (HEPESE). Depressive symptoms were measured by the Center of Epidemiological Studies Depression Scale (CES-D). The trajectories of CES-D, modeled by random effect, were used as independent variables to fit the mortality curve adjusted by other variables including demographics and physical functioning. Results: The separate Cox regression couldn’t identify association between depressive symptoms and survival. The joint analysis indicated that the slope of CES-D score was not associated with mortality in older Mexican-Americans, however the intercept had negative effects on mortality. Conclusion: There was significant association between baseline depression symptoms and mortality, while no association with slope in older Mexican Americans
Metabolic complications of antiretroviral therapy (ART) in a South African black population..

xx 1. CHAPTER ONE: INTRODUCTION AND BACKGROUND . 1 1.1 Lipodystrophy . 1 1.2 Antiretroviral Therapy in South Africa . 5 1.3 Cardiovascular Risk Factors . 8 1.4 Aims and Objectives . 11 2. CHAPTER TWO: RESEARCH DESIGN AND METHODS . 13 2.1. Section A . 13 2.1.1. Study Design . 14 2.1.2. Study Population . 17 V 2.2. Section B . 18 2.2.1. Study Procedures . 18 2.2.2. Demographic Information . 18 2.2.3. Medical History . 18 2.2. 4. Physical Examination . 19 2.3. Section C . 28 2.3.1. Statistical Analysis . 28 3. CHAPTER THREE: BASELINE RESULTS . 34 3.1 Enrolment . 34 3.3. Demographic and Baseline Characteristics . 36 3.3.1. Demographic . 36 3.3. Fat loss and gain . 41 3.3.1. Participant self-report . 41 3.3. 2. Physician evaluation report . 43 3.3.3. Concordance between participant report and physician examination . 57 3.3. 4. Association between lipoatrophy and lipohypertrophy . 57 4. CHAPTER FOUR: BASELINE RESULTS . 65 4.1. Glycaemic indices . 65 4.2. Lipid Measurements . 71 4.3. Inflammatory markers/haematological and other blood tests . 74 4.4. Risk factors associated with diabetes and dysglycaemia at baseline. 77 4.4.1. Diabetes . 77 4.4.2. Dysglycaemia (Diabetes or IGT or IFG) . 77 VI 5. CHAPTER FIVE: LONGITUDINAL STEP . 81 5.1. Follow up and response rate . 81 5.2. Treatment Allocation . 84 5.3. Characteristics at baseline and at follow-up . 86 5.3.1. Clinical . 86 5.4. Fat loss and gain at follow up . 89 5.4.1. Participant self-report . 89 5.4.2. Physician evaluation report . 91 5.5. Concordance between participant report and physician examination . 101 5.6. Associations with peripheral lipohypertrophy . 108 6. CHAPTER SIX: INCIDENCE OF DIABETES MELLITUS AND OTHER DISORDERS OF GLYCAEMIA (DYSGLYCAEMIA) IN SUBJECTS COMMENCED ON ART . 110 6.1. Follow-up OGTT . 110 6.2. Incidence of disorders of glycaemia (dysglycaemia) . 113 6.3. Risk Factors Analysis . 121 6.3.1. Risk factors for diabetes mellitus. 121 6.3. 2. Impaired Glucose Tolerance . 138 6.3.3. Risk factors for impaired fasting glucose (IFG) . 147 6.3. 4. Risk factors for impaired glucose regulation (IGR)/Pre-diabetes . 155 6.3. 5. Risk factors for any disorder of glycaemia (Diabetes Mellitus or impaired glucose tolerance or impaired fasting glucose) . 164 Table 6.44: Multivariate models for incident Diabetes Mellitus, Impaired Glucose tolerance and Impaired Fasting glucose . 173
Ground-Water Resources of Kings and Queens Counties, Long Island, New York

The aquifers beneath Kings and Queens Counties supplied an average of more than 120 Mgal/d (million gallons per day) for industrial and public water supply during 1904-47, but this pumping caused saltwater intrusion and a deterioration of water quality that led to the cessation of pumping for public supply in Kings County in 1947 and in western Queens County in 1974. Since the cessation of pumping in Kings and western Queens Counties, ground-water levels have recovered steadily, and the saltwater has partly dispersed and become diluted. In eastern Queens County, where pumpage for public supply averages 60 Mgal/d, all three major aquifers contain a large cone of depression. The saltwater-freshwater interface in the Jameco-Magothy aquifer already extends inland in southeastern Queens County and is moving toward this cone of depression. The pumping centers' proximity to the north shore also warrants monitoring for saltwater intrusion in the Flushing Bay area. Urbanization and development on western Long Island since before the turn of this century have caused significant changes in the ground-water budget (total inflow and outflow) and patterns of movement. Some of the major causes are: (1) intensive pumping for industrial and public supply; (2) paving of large land-surface areas; (3) installation of a vast network of combined (storm and sanitary) sewers; (4) leakage from a water-supply-line network that carries more than 750 Mgal/d; and (5) burial of stream channels and extensive wetland areas near the shore. Elevated nitrate and chloride concentrations throughout the upper glacial (water-table) aquifer indicate widespread contamination from the land surface. Localized contamination in the underlying Jameco-Magothy aquifer is attributed to downward migration in areas of hydraulic connection between aquifers where the Gardiners Clay is absent. A channel eroded through the Raritan confining unit provides a pathway for migration of surface contaminants to the Lloyd aquifer sooner than anticipated. Although ground water in the Lloyd aquifer is still pristine, present pumping rates and potentiometric levels in the Lloyd aquifer indicate that it is much more sensitive to withdrawals than the other aquifers are and contains an extremely limited water supply.
A QUASI-NORMAL SIMULATION OF AGGRADATION AND DOWNSTREAM FINING WITH SHOCK FITTING

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Gender as an influencer of online health information seeking and evaluation behaviour

This is the peer reviewed version of the following article: Rowley, J., Johnson, F. and Sbaffi, L. (2017), Gender as an influencer of online health information-seeking and evaluation behavior. J Assn Inf Sci Tec, 68: 36–47, which has been published in final form at: https://doi.org/10.1002/asi.23597. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Classification of irreducible symmetric spaces which admit standard compact Clifford–Klein forms

: We give a classiﬁcation of irreducible symmetric spaces which admit standard compact Cliﬀord–Klein forms. The method uses representation theory over the real number ﬁeld and the criterion for properness and cocompactness of the action on homogeneous spaces due to T. Kobayashi.