Miracle-dz/UniFAR-FTUs huggingface dataset:
Now or Later? Emotional Factors and Decision-Making in Cocaine Use Disorder

Cocaine use disorder (CUD) remains a major public health concern, contributing significantly to death and disability. One defining feature of CUD is the repeated use of cocaine at the expense of alternative rewards. While use of cocaine quickly leads to rewarding effects, working towards alternative, long-term goals tends to involve more delay until reward receipt. Rewards are generally perceived as worth less when people must wait longer to receive them, a phenomenon called delay discounting. Individuals with CUD show steep delay discounting, indicating that they perceive the value of the reward as quickly decreasing as the delay increases. This study focuses on the relationship of delay discounting with distress tolerance and depression symptoms, including anhedonia. These factors are functionally significant areas of deficit in CUD and show promise for future treatment. We hypothesized: (1) lower distress tolerance will relate to steeper delay discounting in treatment-seeking individuals with CUD and (2) higher levels of depression symptoms and anhedonia will relate to steeper delay discounting in treatment-seeking individuals with CUD, although we also tested for possible quadratic relationships with discounting. Participants included treatment-seeking individuals with CUD. Distress tolerance was measured using a self-report questionnaire (Distress Tolerance Scale) and a behavioral measure of pain tolerance (Cold Pressor Task). Depression symptoms were self-reported on the Beck Depression Inventory Second Edition, and anhedonia was self-reported on the Snaith-Hamilton Pleasure Scale. To assess the relationship between these factors and temporal decision-making, we used multiple regression analyses with AUClog and log k from the delay discounting task as dependent variables. Results showed that self-reported distress tolerance showed no relationship with delay discounting, but lower levels of physical distress tolerance were associated with steeper delay discounting. Depressive symptoms showed a quadratic relationship with delay discounting, such that low and high levels of depression were associated with steeper delay discounting than moderate levels. Anhedonia showed a quadratic relationship with delay discounting as well, but moderate levels of anhedonia were associated with steeper delay discounting in comparison to low and high levels. Findings provide insight into the distinct relationship which tolerating physical distress may have with delay discounting in CUD. The unique relationships reported here for depression and anhedonia with delay discounting likely indicate differential associations of mood and reward-processing with decision-making in CUD. These findings offer deeper insight into decision-making in this population and a variety of potential treatment targets for further analysis.
University Students’ Attitudes toward the Formal Integration of Facebook in their Education: Investigation Guided by Rogers' Attributes of Innovation

The aim of the study was to examine students’ attitudes toward the formal integration of Facebook in their education at Al- Hussein Bin Talal University and to examine the relationship between their attitudes and their perceptions of Facebook’s attributes. The investigation was guided by Rogers' (2003) attributes of innovation. A descriptive method was adopted in which a questionnaire was used to collect data from 99 undergraduate university students from the college of education. The results show that the students have positive and high attitudes toward the formal integration of Facebook in their teaching. In addition, the students have positive perceptions of Facebook in terms of its relative advantage, ease of use, compatibility, trialability, and observability. Furthermore, Regression analysis showed that 46% of the variance of the students’ attitudes toward the formal integration of Facebook in their education can be accounted for by its linear relationship with the five independent variables: relative advantage, ease of use, compatibility, trialability, and observability. Based on the results, set of recommendations were provided.
Window Shopping Assisted by Geoenzo to Increase Students’ Conceptual Understanding in Mathematics to Learning Interest

Tujuan penelitian ini adalah untuk mengetahui: 1) pengaruh model pembelajaran Windows Shopping berbantuan Geoenzo terhadap kemampuan konsep matematis; 2) pengaruh minat belajar terhadap kemampuan konsep matematis; dan 3) interaksi antara h model pembelajaran Windows Shopping berbantuan Geoenzo dengan minat belajar terhadap kemampuan konsep matematis. Jenis penelitian yang digunakan untuk mencapai tujuan penelitian adalah eksperimen semu. Teknik pengumpulan data yang digunakan adalah tes, dokumentasi dan angket (kuisioner), yang selanjutnya akan di uji menggunakan uji analysis of varians (anova). Hasil penelitian menunjukkan bahwa: 1) terdapat pengaruh antara model Windows Shopping terhadap kemampuan pemahaman konsep matematis; 2) Kategori minat belajar (tinggi, sedang, rendah) peserta didik tidak berpengaruh terhadap kemampuan pemahaman konsep matematisnya; 3) tidak ditemukan interaksi antara model pembelajara Windows Shopping berbantuan software geoenzo dengan minat belajar terhadap kemampuan pemahaman konsep matematis peserta didik.
The High-Volume Return Premium and Economic Fundamentals

Extending Kaniel, Ozoguz, and Starks (2012, J. Financ. Econ.) and many others, we present first empirical evidence that indicates the high volume return premium is linked to economic fundamentals. The volume premium has strong predictive power for future industrial production growth and other macroeconomic indicators with or without controls for common equity pricing factors and business cycle variables. However, only a small portion of the volume premium can be attributed to its co-movement with equity return factors and economic risk factors. Mis-pricing-based factor models also fail to adequately explain the return anomaly.
Interactive Effect of Fluorescent Pseudomonads Rhizobacteria and Zn on the Growth, Chemical Composition, and Water Relations of Pistachio (Pistacia vera L.) Seedlings under NaCl Stress

ABSTRACT The role of fluorescent pseudomonads isolates (pf0, pf1, pf2, and pf3) and zinc (Zn) (0 and 5 mg kg−1 soil) interactions in alleviating salinity in pistachio seedlings were investigated. The experiment was conducted following completely randomized design with three replicates. The results revealed that salinity decreased the growth parameters, while application of PGPR (plant growth-promoting rhizobacteria) and Zn increased these parameters. Application of PGPR significantly enhanced phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg), Zn, Ca/sodium (Na), and K/Na contents, while decreased the accumulation of Na and chloride (Cl). Application of PGPR and Zn increased the phenolic compounds, sucrose, membrane stability index (MSI), and relative water content (RWC) but reduced the malondialdehyde (MDA) amount. A positive correlation was observed between Zn concentrations with seedling dry weights, phenolic compounds, MSI, and RWC contents. These results indicated that the combined application of PGPR and Zn could be a simple treatment for growth and establishment of pistachio seedlings under Zn deficiency and soil salinity.
Aqueous Extracts of Pentaclethra macrophylla Bentham Roots as Eco-Friendly Corrosion Inhibition for Mild Steel in 0.5 M KOH Medium

This work is devoted to examine the effectiveness of the aqueous extracts of Pentaclethra macrophylla Bentham root on corrosion of mild steel in 0.5 M KOH solution using the weight loss measurement at room temperature and concentration effects. Potentiodynamic polarization method was employed to evaluate corrosion rate and inhibition efficiency. Corrosion inhibition efficiency of 84.02 % was achieved at 0.3 g/L in 0.5 M KOH of Pentaclethra macrophylla Bentham root extract. It was found that the root extracts acted as a good inhibitor for the tested environment. The inhibitive action of the extract is discussed with a view to adsorption of its components onto the mild steel surface which made a barrier to mass and charge transfer. The adsorption of extract components onto the steel surface was found to be a spontaneous process and increases the activation energy of the corrosion process. The inhibition efficiency is greatly reduced as the temperature increased. Experimental results show that corrosion inhibition efficiency increases with concentration of the sample extract. Furthermore, the extract and corroded metals were characterized by Energy dispersive X-ray spectroscopy and Scanning electron micrograph techniques. Adsorption behavior of the extract was also studied, which suggest Langmuir isotherm model as a most suitable adsorption mechanism. The data derived from the Potentiodynamic polarization confirmed the fact that corrosion inhibition mechanism was affected by the studied root extracts.
Growth hormone alleviates oxidative stress and improves IVF outcomes in Chinese women with poor ovarian response: A randomized controlled trial

Background Oxidative stress (OS), defined as an imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) excessive production and antioxidant insufficient, has been suggested to be involved in the pathogenesis of poor ovarian response (POR). Growth hormone (GH) can function reduce OS in some types of cells. This study investigated whether GH can significantly improve OS and in vitro fertilization and embryo transfer (IVF-ET) outcomes in patients with POR.Methods This study enrolled 105 and 58 patients with and without POR (controls), respectively, diagnosed according to the Bologna criteria, who underwent conventional IVF-ET. Patients with POR were randomly assigned to two groups: POR-GH group: pretreatment with GH 4IU/d on day 2 of the previous menstrual cycle before IVF till the trigger day; POR-C group: no pretreatment. The markers of OS in follicle fluid (FF),reactive oxygen species (ROS) levels in granulosa cells (GC), and IVF outcomes of the patients were compared between the three groups.Result(s) The endometrial thickness on trigger day, number of cleaved embryos, higher quality embryos, the rates of implantation and clinical pregnancy were significantly increased in POR-GH group compared with POR-C group (P<0.05). Moreover, the FF malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI) and ROS levels in GC were significantly higher,whereas superoxide dismutase (SOD) and total antioxidant capacity (TAC) were significantly lower in POR-C group compared with non-POR group (P<0.05). Furthermore, the FF TAC was significantly increased, whereas TOS, OSI and intracellular ROS levels were significantly reduced in POR-GH group compared with POR-C group (P<0.05). Conclusion(s) Pretreatment with GH alleviated OS and improved oocyte quality and IVF outcomes in patients with POR.Clinical Trial Registration: Chinese Clinical Trial Registry. ChiCTR1900021269. Registered 8 February 2019, http://www.chictr. org.cn/edit.aspx? pid=35837&htm=4.
Age Chronosequence Effects on Restoration Quality of Reclaimed Coal Mine Soils in Mississippi Agroecosystems

Abstract Surface mining drastically disturbs landscapes and soil properties. Reclamation can restore and improve soil quality and biomass productivity. Time required for soil reclamation to restore soil quality to premined conditions in southeastern United States is unclear. The objective of this study was to evaluate chronosequence effects on restoration quality indicators in reclaimed coal mine soil from different land use landscapes and agroecosystems in Mississippi. Study sites in 0‐ to 3‐, 5‐ to 7‐, and 10‐ to 12‐year‐old reclaimed soils were compared with adjacent undisturbed sites. Soil samples collected at the 0‐ to 15‐cm and the 15‐ to 30‐cm depths within a grid in a radius of 3 m were mixed to produce composite samples and kept frozen until analyzed. Soil bulk density (&rgr;b) was the highest (1.48 g cm−3) in the youngest (< 1 year) site and decreased with increasing age to the oldest (12‐year) site (1.07 g cm−3). Soil quality indicators (aggregate stability, total C, organic C, and microbial biomass C) increased with increasing reclamation age in forest and grass ecosystems. Concentrations of C were greater at the summit than at shoulder and foot‐slope positions. Soil pH, Ca, Mg, Cu, and Zn were higher in newly reclaimed soil than in soils reclaimed 12 years earlier possibly because of reclamation liming practices, which buffer pH to greater than 7.0 in newly reclaimed sites. Reclamation practices improved soil quality over time. Soil quality indicators reached levels similar to those of undisturbed soil within 7 to 12 years after reclamation, indicating successful reestablishment of healthy and sustainable soils in the postmining ecosystems.
Analysis on the MRI Results of Neonatal Brain with Different Levels of Bilirubin

Numerous studies have focused on abnormal changes in craniocerebral MRI in neonates at severe bilirubin levels, and no abnormal changes have been reported at moderate and low levels, and the abnormal changes are related to gestational age, birth weight and bilirubin levels And other factors. Here, by analyzing the neonatal craniocerebral MRI manifestations at different levels of bilirubin, it is found that at moderate and low levels of bilirubin, the neonatal cranial MRI has abnormal changes, and the craniocerebras at severe bilirubin levels MRI abnormal changes were not statistically significant, and were not significantly related to gestational age, birth weight, and bilirubin levels. This suggests that neurotoxicity may occur at low and medium levels of bilirubin.
Comparison Between 200 μg and 800 μg of Misoprostol for Cervical Ripening Prior to Operative Hysteroscopy: A Study Protocol for A Randomized Controlled Trial.

Background: Hysteroscopy, a minimally invasive procedure, has been increasingly used to treat disorders of the cervical canal and uterine cavity. However, difficulties related to the insertion of the hysteroscope through the cervical canal still remain. Although there are reported advantages in reducing cervical resistance with the use of misoprostol for cervical ripening, systematic reviews highlight the need to determine the optimal dose. This study was designed to compare two groups of patients submitted to cervical dilatation prior to operative hysteroscopy and pre-treated with either 200 µg or 800 µg of misoprostol for cervical ripening. Methods: A randomized, quadruple-blind clinical trial with patients submitted to cervical dilatation prior to operative hysteroscopy at university teaching hospitals in Recife, Pernambuco, Brazil. After the internal review boards of the participating institutes had approved the study protocol, data collection began on November 7, 2019, with expected completion on November 1, 2020. Patients included in the study following the informed consent process are randomly allocated to one of two groups, the first allocated to use 200 μg misoprostol and the second to use an 800-μg dose. In both groups, misoprostol will be administered vaginally 10-12 hours prior to operative hysteroscopy. The groups will be compared in relation to intraoperative and postoperative outcomes based on the following endpoints: baseline cervical dilatation, cervical length, degree of difficulty, duration of cervical dilatation, failure to dilate, adverse events and surgical complications. The chi-square test of association, Fisher's exact test and the Mann-Whitney test will be used to compare the groups, with an alpha error of <5% being considered significant. Discussion: The findings of this study will contribute towards establishing the optimal misoprostol dose for cervical ripening prior to operative hysteroscopy, ultimately facilitating hysteroscope insertion through the cervical canal. A gap will be filled in the currently available literature, providing future preoperative guidance. The 800-μg dose of misoprostol is expected to reduce resistance in the cervix and shorten the time until achieving cervical dilatation, delivering a less traumatic procedure for the patient. Therefore, the study is relevant for surgeons in this field, for the scientific community and, particularly, for patients. Trial registration: Clinical Trials Register: NCT04152317. Registered on November 5, 2019. URL https://clinicaltrials.gov/ct2/show/study/NCT04152317.
Expression of MicroRNA-155 and Suppressor of Cytokines Signaling 1 (SOCS1) mRNA in Plasma Breast Cancer Patients

: Breast cancer is the most common cancer in women worldwide. miR-155 has been discovered to have an important role in the development of breast cancer. miR-155 targets many mRNAs of tumor suppressor genes, one of them is SOCS1. The discovery of miRNA in body fluids provides a novel alternative for the development of minimally invasive biomarker in cancer. However, limited study has been reported on the expression of miR-155 and SOCS1 mRNA in plasma breast cancer patients especially in Indonesian population.This study analyzed expressions of miR-155 and SOCS1 mRNA in plasma breast cancer patients This study was conducted using cross-sectional design, 32 plasma samples were collected from Dr.Sardjito Hospital. RNA was extracted from plasma and then cDNA was synthesized from RNA samples. Real-time qPCR was used to detect expression of miR-155 and mRNA SOCS1. Both expression was analyzed using Livak's method. The significance of the results were tested statistically using independence T-test. Expression of miR-155 at advanced stage was 2.43 higher than the early stages (p=0.047), while the mRNA expression of SOCS1 at advanced stage was 1.29 lower than early stage (p=0.170). Expression of miR-155 in ER, PR, & HER2 status revealed differences among subgroups, while the mRNA expression of SOCS1 was not significantly different. Other result showed that miR-155 expression was higher in triple negative tumor, while SOCS1 higher in luminal A tumor. Nevertheless, the difference was also not statistically significant (p value > 0,05). This study showed that expressions of miR-155 and SOCS1 mRNA was deregulated in breast cancer plasma and it believed to have an important role in breast cancer.
Reducing the Secondary Structure Bias in the Generalized Born Model via R6 Effective Radii

The generalized Born model (GB) provides a reasonably accurate and computationally efficient way to compute the electrostatic component (ΔGel) of the solvation free energy. In this work, we have developed a method to compute effective Born radii, which is intended to address the known secondary structure bias of the GB model reported earlier (Roe et al. J. Phys. Chem. B, 2007, 111, 1846−1857). Our analytical approach, termed AR6, is based on the |r|−6 (R6) integration over an approximation to molecular volume. Within the approach, several computationally efficient corrections to the pairwise VDW−volume integration are combined to closely approximate the true molecular volume in the vicinity of each atom. The accuracy of the AR6 model in predicting relative ΔGel is tested on four conformational states of alanine decapeptide. Changes in ΔGel estimated by AR6 between various pairs of conformational states have the same RMS error relative to the explicit solvent, as do the corresponding numerical PB values; a.
AQR Plays a Key Role in Splicing Fidelity in Higher Organisms

BackgroundThe structures of the spliceosome have been resolved in different complexes, but the functions of spliceosome components in splicing fidelity are largely unclear. A few proteins, such as SLU7 and EJC, are known to have roles in splicing fidelity.ResultsIn this work, through a systematic analysis of the cryptic splice sites in humans, mice and fruit flies using shRNA-seq and siRNA-seq datasets, I ranked the importance of different proteins in splicing fidelity. The important proteins include IBC, EJC, SLU7, Prp22 and other splicing-related factors, especially AQR, whose knockdown induced the highest number of cryptic splice sites in K562, N2A, and CGR8, suggesting its central role in splicing fidelity in higher organisms. The metaprofiles of the cryptic splice sites for AQR and Prp17 further indicate that cryptic 3' splice sites can induce cryptic exons, which then contribute to cryptic 5' splice site generation.ConclusionsI analyzed siRNA-seq/shRNA-seq from a new angle. I found that AQR knockdown induced the highest number of cryptic 5' and 3' splice sites in three cell lines and that RBP knockdown mainly induced cryptic 3' splice sites, which then induced cryptic 5' splice sites.
Diversity and Endogenous Knowledge of Aphrodisiac Plants in South and Central Benin

Background: The use of aphrodisiac plants is a very common and ancient practice in Africa. This study, conducted in central and southern Benin, aimed to document endogenous knowledge related to flora, valorization, promotion and conservation of plants species used for aphrodisiac purposes.Methods: Data were collected using ethnobotanical and market surveys from 134 people followed by observations.Results: A total of 138 aphrodisiac plants species were recorded, including 72 from Center Benin and 20 from South Benin while 46 species were common to both areas. These species belong to 124 genera from 59 families mostly represented by Fabaceae (14.49%), Euphorbiaceae (8.76%), and Poaceae (4.38%). The predominant biological type was Phanerophytes (57.25%). The chorological analysis identified a dominance of Sudano-Guinean (26.09%), Pantropical (24.64%) and Guinea-Congolian species (19.57%). Aphrodisiac plants were used for 220 recipes to treat eight affections from which the common was sexual weakness (88.80%). Roots (33.12%) and leaves (20.13%) were the most used parts. The maceration (44.76%) and oral route (88.11%) were the main galenic form and the main mode of administration, respectively.Conclusion: This flora represents a raw material for subsequent phytochemical characterization to identify new aphrodisiac properties, leading to produce Improved Traditional Medicines against sexual disorders.
Immunological response to COVID-19 and its role as a predisposing factor in invasive aspergillosis

The world is involved with a pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2. The clinical manifestations of reported COVID-19-associated pulmonary impairments range from asymptomatic infections to a pneumonia-induced acute respiratory distress syndrome that requires mechanical ventilation. Fungal superinfections complicating the clinical course remain underexplored. Angiotensin-converting enzyme 2, the receptor for COVID-19 that is mainly expressed in airway epithelia and lung parenchyma, is considered an important regulator of innate immunity. With regard to the viral-cell interaction, imbalanced immune regulation between protective and altered responses caused by the exacerbation of inflammatory responses should be considered a major contributor to secondary pulmonary aspergillosis. In addition, the complex inherited factors, age-related changes, and lifestyle may also affect immune responses. The complication and persistence of invasive aspergillosis have been well described in patients with severe influenza or COVID-19. However, there is a scarcity of information about the immunological mechanisms predisposing patients with COVID-19 to fungal co-infections. Therefore, this study was conducted to investigate the aforementioned domain.