Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcomes Based on Blood Pressure in Patients on Continuous Flow LVAD Support: An INTERMACS analysis

Background: An optimal blood pressure (BP) range to mitigate morbidity and mortality on left ventricular assist device (LVAD) support has not been clearly defined. Methods: Average Doppler opening pressure, mean arterial pressure (MAP), and/or systolic blood pressure (SBP) were calculated in operative survivors (n=16155) of LVAD support in INTERMACS. BP distributions were used to group patients: low (BP <25th percentile), normal (25-75th percentile), high (75th-95th) and very high (>95th percentile). Associations between BP and adverse events were evaluated using Cox Regression (Hazard ratio (HR), 95% confidence interval). Results: The median MAP, Doppler, and SBPs (mmHg) during CFLVAD support were 84 [77, 90], 85 [80, 92], and 99 [90,107] mmHg. BP had a bimodal risk association with survival. At 3 years, survival was 58±1.8% in those with low MAPs (≤75 mmHg) vs. 70±0.9%, 71±1.5%, and 63±3.0% in the those with normal, high, or very high average MAPs. Patients with chronically low MAPs (≤75 mmHg), Dopplers (≤80 mmHg) and SBPs (<90 mmHg) had 35-42% higher adjusted hazards of death than patients with normal or high BPs (p≤0.0001). Patients with MAPs >100 mmHg, Dopplers ≥105 mmHg, and SBPs ≥120 mmHg had 17-20% higher adjusted hazards of death than those with normal pressures (p<0.05). In patients on axial flow LVADs, elevated SBP Corresponding Author: Jennifer Cowger, MD, MS, Medical Director of the Mechanical Circulatory Support Program. Henry Ford Hospitals, 2799 W Grand Blvd, K 14, Detroit, MI 48202, Cell (do not publish) 734.546. 4911, Fax: 313.916. 8799, jennifercowger@gmail.com. Disclosures: All investigators work at institutions that receive clinical grant support from Abbott and Medtronic. J Cowger receives compensation from Abbott and Medtronic for speaking engagements and is on the Medtronic Scientific Advisory Committee and the INTERMACS Scientific Committee. P Shah reports grant support from American Heart Association / Enduring Hearts Scientist Development Grant, Merck for unrelated research and consulting for NuPulse CV, Procyrion and Ortho Clinical Diagnostics. S. Pinney receives consulting and speaking fees from Abbott and Medtronic. No other authors have additional disclosures to present. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author manuscript J Heart Lung Transplant. Author manuscript; available in PMC 2021 May 01. Published in final edited form as: J Heart Lung Transplant. 2020 May ; 39(5): 441–453. doi:10.1016/j.healun. 2019.11. 016. A uhor M anscript
Use of 5- (cid:1) -Reductase Inhibitors for Prostate Cancer Chemoprevention: American Society of Clinical Oncology/ American Urological Association 2008 Clinical Practice Guideline

Purpose To develop an evidence-based guideline on the use of 5- (cid:1) -reductase inhibitors (5-ARIs) for prostate cancer chemoprevention. No speciﬁc cut point or change in PSA has been prospectively validated in men taking a 5-ARI. J Clin Oncol 27:1502-1516. This guideline was developed through a collaboration between the American Society of Clinical Oncology and the American Urological Association and has been published jointly by invitation and consent in both the Journal of Clinical Oncology and Journal of Urology. Copyright © 2009 American Society of Clinical Oncology and American Urological Association. All rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without written permission by the American Society of Clinical Oncology or the American Urological Association
Demand Shock along the Supply Chain: The Bullwhip Effect of Covid-19 in Chinese Exports

This study investigates the bullwhip effect of Covid-19 on global supply chains from the Chinese perspective. The bullwhip effect refers to the amplification of demand shock along the supply chain, and my baseline estimates show that a 1% increase in foreign new cases (a proxy for foreign demand shock) reduces exports of downstream products and that of upstream industries by 2.1% and 4.5% respectively. The estimates also suggest that whether industries are concentrated or not generates ambiguous effects on exports that vary from different empirical specifications. In addition, a heterogeneity analysis suggests that the bullwhip effect is stronger in regional supply chains among geographically proximate countries and countries that are closely connected in terms of the trade volume. Furthermore, a dynamic analysis shows that the outbreak of Covid-19 in foreign countries causes a lagged import substitution towards Chinese products that reverses the initially negative demand shock. Unlike the initial adverse effect, I find that the lagged import substitution does not amplify along the supply chain, but mostly affects downstream industries.
Heparin induced thrombocytopenia-type 2

1. Gertz MA. Management of cold haemolytic syndrome. Br J Haematol 2007;138:422-9. 2. Berentsen S, Ulvestad E, Gjertsen BT, Hjorth-Hansen H, Langholm R, Knutsen H, et al. Rituximab for primary chronic cold agglutinin disease: A prospective study of 37 courses of therapy in 27 patients. Blood 2004;15;103:2925-8. 3. Palombi M, Niscola P, Trawinska MM, Scaramucci L, Giovannini M, Perrotti A, et al. Long-lasting remission induced by rituximab in two cases of refractory autoimmune haemolytic anaemia due to cold agglutinins. Blood Transfus 2009;7:235-6. 4. Delluc A, Pasquier E, de Saint Martin L, Mottier D. Rituximab’s cost for the treatment of primary cold agglutinin disease should not limit its use. Haematologica 2006;91:ECR05.
Appendix Comparison With MTL Methods

As mentioned in the Empricial Evaluation Section, DiSparse surpasses several dedicated multitask learning approaches despite the high sparsity enforced in our model. In Table 1, we show comparison of DiSparse in both static and dynamic sparse training setting with several MTL approaches including DEN [1], Sluice [10], and CrossStitch [8] applied on exactly the same model with the same optimization settings. The superiroty of DiSparse is clearly observed in the table, demonstrating that DiSparse is not only an effective compression approach but also a powerful tool for multitask learning.
Multi-Agent Dynamic Ergodic Search with Low-Information Sensors

The long-term goal of this work is to enable agents with low-information sensors to perform tasks usually restricted to ones with more sophisticated, high-information sensing capabilities. Our approach is to regulate the motion of these low-information agents to obtain “high-information” results. As a first step, we consider a multi-agent system tasked with locating and tracking a moving target using only noisy binary sensors that measure the presence (or lack thereof) of a target in the sensor's field of view. To generate effective paths for these agents, we use ergodic trajectory optimization with a novel mutual information map that is fast to compute and can handle the discontinuous measurement models often associated with low-information sensing. We compare our approach with existing motion planning methods in multiple simulated experiments. Our experiments show that agents using our method outperform purely coverage-based approaches as well as naive ergodic approaches.
THE ROLE OF THE SPLEEN

were employed to test the hypothesis that the early phase (< 72 h) of pyrogenic tolerance to endotoxin is independent of anti-endotoxin antibody but that such antibody contributes significantly to the later phase (. 72 h) of tolerance. In the splenectomized rabbit, the initial pyrogenic responses to ET and the subsequent tolerant responses at 24 and 48 h were comparable to sham-operated controls. Thereafter, splenectomized rabbits exhibited impaired ability to acquire further pyrogenic tolerance. Such impairment was evidenced by significantly retarded rates of tolerance commencing 72 h after daily i.v. injections of ET and by significantly reduced tolerance 5 days after a single i.v. injection of ET. Similarly, healthy splenectomized human volunteers exhibited pyrogenic and subjective toxic responses to an initial i.v. injection of ET comparable to volunteers with intact spleens. Upon retesting 5 days later, however, the splenectomized volunteers exhibited significantly reduced levels of tolerance. When additional ET was subsequently administered, tolerance increased progressively in all volunteers, but its rate of maturation was significantly retarded in the splenectomized subjects. To reproduce equivalent impairment of the late phase of tolerance in volunteers with intact spleens, the immunizing doses of ET had to be decreased to levels extrapoReceived for ptublicationt 18 Afarch 1975 anid iJ revised formii 31 Jutly 1975. lated to fall between 1/10 and 1/100 of those used in the splenectomized subjects. The impairment of latephase pyrogenic tolerance after splenectomy appeared to be the result of the concomitant suppression of antiendotoxin antibody production rather than the loss of splenic reticuloendothelium required to clear and inactivate the ET. This was evidenced by: (a) the significant retardation in appearance of humoral factors in the splenectomized rabbits capable of transferring high levels of specific tolerance; (b) the inability to impair the late phase of tolerance in human volunteers with intact spleens until the immunizing doses of endotoxin were reduced to levels that virtually eliminated circulating anti-endotoxin antibody production; (c) the unimpaired development of tolerance in partially hepatectomized rabbits lacking more functional reticuloendothelium than splenectomized animals, but capable of normal anti-endotoxin antibody synthesis. It is concluded that in rabbit and man the spleen plays no important role in the initial pyrogenic response to i.v. ET, or in the early phase of pyrogenic tolerance. The spleen, however, by virtue of its anti-endotoxin antibody-producing capabilities, contributes significantly to the late phase of tolerance after a single i.v. injection of ET and accelerates significantly its rate of acquisition after repetitive i.v. injections of the toxin.
Revisiting Volkova ’ s Integrated Translation Model in Relation to Untranslatability : Acknowledgement of Literary Translator

Since Volkova’s (2012) discourse and communication translation model reformulates a translation strategy as a flexible, variable, and individual algorithm resulting from a translator’s analysis and interpretation of the various features of a given text, it underlines such innovative workarounds as an inevitable parameter during the translation process. This, in turn, backs the notion that untranslatability, despite being resistance to translation, i.e. reflective of the inability to translate specific texts or textual features due to certain cultural, ideological, and linguistic eccentricities, as much ascertained in recent translation studies, is, in fact, productive of creative strategies on the part of translators whether purposefully (on ideological grounds) or spontaneously (on absolute needs of translation problems) to negotiate and overcome such resistance. This creativity nourishes the popular idea in contemporary translation literature that literary translators should be identified as writers of their own translations. That is, they are not only producers of cultures but also writers of literary works proper or at the very least of derivatives of the original works since they are likely to manipulate the content and imaginative world of the original work as well as its moral and political claims, if any. Accordingly, the present study aims at backing the acknowledgement of the literary translator as writer (TW) via both investigating the concept of untranslatability in literary works and the creative strategies it necessitates and revisiting Volkova’s integrated model of translation, which is supportive and representative of the translator’s innovation and individuality. By feeding the featuresuntranslatabilitiescreative workarounds concept/tactic into the revisited model, which has been revealed as an inescapability in literary translation, the study attempts to enhance such model to encompass both untranslatability and TW, hence contributing to the acknowledgement of TW.
Impact of sidewall spacer on gate leakage behavior of nano-scale MOSFETs

Semiconductor devices with a low gate leakage current are preferred for low power application. As the devices are scaled down, sidewall spacer for CMOS transistor in nano-domain becomes increasingly critical and plays an important role in device performance evaluation. In this work, gate tunneling currents have been modeled for a nano-scale MOSFET having different high-k dielectric spacer such as SiO2, Si3N4, Al2O3, HfO2. The proposed model is compared and contrasted with Santaurus simulation results and reported experimental result to verify the accuracy of the model. The agreement found was good, thus validating the developed analytical model. It is observed in the results that gate leakage current decreases with the increase of dielectric constant of the device spacer. Further, it is also reported that the spacer materials impact the threshold voltage, on current, off current, drain induced barrier lowering and subthreshold slope of the device.
Doxorubicin generates a pro-apoptotic phenotype by phosphorylation of EF-2

We have previously shown that doxorubicin sensitizes prostate cancer cells to TNF-Related Apoptosis Inducing Ligand (TRAIL). Sensitization correlated with decreased expression of the antiapoptotic protein cFLIPS. The decrease in cFLIPS could not be explained by transcriptional regulation or increased degradation, leading us to focus on translational mechanisms. In this study, we found that doxorubicin caused strong and sustained phosphorylation of elongation factor 2 (EF-2), which interferes with protein elongation. Phosphorylation of EF-2 appeared to occur in a kinaseindependent manner. Treatment with hydrogen peroxide recapitulated the events observed after doxorubicin treatment. In addition, cells treated with hydrogen peroxide expressed less XIAP and survivin which, like cFLIPS, are short half-life proteins with an anti-apoptotic function while expression levels of DR5, caspases-8, -9, -3, and Bax are maintained. The doxorubicin-mediated decrease in cFLIPS and XIAP as well as TRAIL-induced apoptosis was prevented by pretreatment with an iron chelator, indicating that expression of these proteins was affected by free radical generation upon interaction of iron with doxorubicin. In conclusion, our data suggest that free radicals can affect the phosphorylation of EF-2 resulting in a net loss of short half-life proteins such as cFLIPS and XIAP, leaving a cell more vulnerable to apoptotic stimuli.
Social Welfare Analysis of Policy-based Finance with Support for Corporate Loan Interest†

We analyze the social welfare effect when a policy-based financial system (PFS) enters a decentralized financial market. Particularly, the PFS in this case supports the interest spread for corporate loans held by firms with heterogeneous bankruptcy decisions under an imperfect information structure. Although support for capital costs through the PFS expands the economy consistently, the optimal level of PFS out of the corporate loan market is estimated to be 8.6% by a simulation model considering social welfare adjusted by the disutility of labor. This result is much lower than the recent level of PFS in the Korean financial sector.
THE EFFECTS OF VIRUS-INDUCED MATERNAL INFLAMMATION ON OFFSPRING METHYLATION PATTERNS IN SKELETAL MUSCLE BY

Maternal infection with porcine reproductive and respiratory virus during gestation increased inflammatory cytokine expression in offspring and reduced muscle fiber development. Because maternal environment alters DNA methylation patterns during development, the influence of virus induced maternal inflammation on the methylome in developing muscles was investigated. The hypothesis was that the genome would be hypermethylated in the offspring of infected pigs (Sus scrofa). Pregnant pigs were inoculated with either porcine reproductive and respiratory virus (PRRSV) or sterile culture medium (CON) and longissimus dorsi muscle samples were collected from offspring at birth. Reduced representation bisulfite sequencing was used to determine methylation status of individual CpG sites throughout the genome. Differentially methylated CpG sites were used in pathway and gene ontology analysis. Overall frequency of methylated CpG sites was virtually unchanged between PRRSV (46.36% of CpG sites methylated) and CON offspring (46.30%). Methylation patterns differed between treatments with 5593 cytosines from 717 genes hypermethylated and 566 cytosines from 262 gene hypomethylated in PRRSV piglets as compared to CON piglets. Most differential methylation occurred in intergenic regions. Of these, 102 genes were outliers in terms of the amount of differential methylation between treatments, the most extreme of which includes FcγRII, MEF2C, citrate synthase, and PRKAB2. Additionally, genes from several disease response pathways were hypermethylated, along with genes from the thyroid hormone signaling pathway and oxidative phosphorylation pathway, possibly affecting myosin heavy chain expression in PRRSV piglets. Differential methylation, mostly hypermethylation, was also present in the fast
AJA2000024 1..15

Purpose: This clinical focus article is a companion to the work of Erdman et al. (2019), in which we described the rationale, development, and implementation of the standardof-care protocol used in the Tinnitus Retraining Therapy Trial (TRTT), a multicenter, placebo-controlled, randomized, definitive efficacy trial of tinnitus retraining therapy (TRT). We now describe the historical background, development, and standardized implementation and delivery of the TRT counseling protocol (tinnitus counseling [TC]) used in the TRTT. TC is conjectured to be the key component in the TRT protocol for initiating the habituation process that reduces the response to the tinnitus signal and, ultimately, reduces its impact. In the TRTT, participants assigned to receive TC achieved > 30% reduction in the impact of tinnitus. Method and Results: The design and implementation of standardized treatments in multisite randomized controlled trials presents many challenges for investigators. Here,
Serological and parasitological prevalence of bovine trypanosomosis in small holder farms of the Vina division, Adamawa region of Cameroon

1 School of Veterinary Medicine and SciencesUniversity of Ngaoundere, Cameroon. 2 Institute of Agricultural Research for Development (IRAD) Wakwa Regional Centre, Veterinary Research Laboratory. B.P. 65 Ngaoundere, Cameroon. 3 Ecole inter-Etats des sciences et Médecine Vétérinaire (EISMV), Dakar, Sénégal. 4 Centre International de Recherche et Développement en zone Subhumides (CIRDES), Bobo-Dioulasso. Burkina Faso. 5 Université Polytechnique de Bobo-Dioulasso (UPB), Burkina Faso. 6 Laboratoire de Recherche en Santé et Biotechnologie Animale (LARESBA).
Activation of Nuclear Factor- (cid:1) B via Endogenous Tumor Necrosis Factor (cid:2) Regulates Survival of Axotomized Adult Sensory Neurons

Embryonicdorsalrootganglion(DRG)neuronsdieafteraxonaldamage invivo ,andculturedembryonicDRGneuronsrequireexogenous neurotrophicfactorsthatactivatetheneuroprotectivetranscriptionfactornuclearfactor- (cid:1) B(NF- (cid:1) B)forsurvival.Incontrast,adultDRG neurons survive permanent axotomy in vivo and in defined culture media devoid of exogenous neurotrophic factors in vitro . Peripheral axotomyinadultratsinduceslocalaccumulationofthecytokinetumornecrosisfactor (cid:2) (TNF (cid:2) ),apotentactivatorofNF- (cid:1) Bactivity.We tested the hypothesis that activation of NF- (cid:1) B stimulated by endogenous TNF (cid:2) was required for survival of axotomized adult sensory neurons. Peripheral axotomy of lumbar DRG neurons by sciatic nerve crush induced a very rapid (within 2 h) and significant elevation in NF- (cid:1) B-binding activity. This phenomenon was mimicked in cultured neurons in which there was substantial NF- (cid:1) B nuclear translocation and a significant rise in NF- (cid:1) B DNA-binding activity after plating. Inhibitors of NF- (cid:1) B (SN50 or NF- (cid:1) B decoy DNA) resulted in necrotic cell death of medium to large neurons ( (cid:3) 40 (cid:4) m) within 24 h (60 and 75%, respectively), whereas inhibition of p38 and mitogen-activated protein/extracellular signal-regulated kinase did not effect survival. ELISA revealed that these cultures contained TNF (cid:2) , and exposure to an anti-TNF (cid:2) antibody inhibited NF- (cid:1) B DNA-binding activity by (cid:1) 35% and killed (cid:1) 40% of medium to large neurons within 24 h. The results show for the first time that cytokine-mediated activation of NF- (cid:1) B is a component of the signaling pathway responsible for maintenance of adult sensory neuron survival after axon damage.
CHANGES IN FREE AMINO ACIDS IN THE PLASMA DURING , ATIC COMA-,

Previous reports frmm various laboratories have ances of protein metabolism, which emphasized the failure to demonstrate consistent and significant biochenjicalchanages during hepatic coma (1-3). However, a cross increase of amino acids in the plasma, urine and spinal fluid (4, 5) and an elevation of ammonia in the blood (6-9) have been observed to accompany hepatic coma. Since diseases of the liver often result in disturb-
Individuals Family History Positive for Alcoholism Show fMRI Differences in Reward Sensitivity that are Related to Impulsivity Factors

Background— Substance abusing individuals tend to display abnormal reward processing and a vulnerability to being impulsive. Detoxified alcoholics show differences in regional brain to activation during a monetary incentive delay (MID) task. However there is limited information on whether this uncharacteristic behavior represents a biological predisposition towards alcohol abuse, a consequence of chronic alcohol use, or both. Methods— We investigated proposed neural correlates of substance disorder risk by examining reward system activity during a MID task with separate reward prospect, reward anticipation, and reward outcome phases in 30 individuals with and 19 without family histories of alcoholism. All subjects were healthy, lacked DSM-IV past or current alcohol or substance abuse histories, and were free of illegal substances as verified by a urine toxicology screening at the time of scanning. Additionally, we explored specific correlations between task-related nucleus accumbens (NAcc) activation and distinct factor analysis-derived domains of behavioral impulsivity. Results— During reward anticipation, fMRI data confirmed blunted NAcc activation in family history positive subjects. In addition, we found atypical activation in additional reward-associated brain regions during additional task phases. We further found a significant negative correlation between NAcc activation during reward anticipation and an impulsivity construct. Conclusions— Overall, results demonstrate that sensitivity of the reward circuit, including NAcc, is functionally different in alcoholism FHP individuals in multiple regards.