Miracle-dz/UniFAR-FTUs huggingface dataset:
An Advanced Automated Image Analysis Model for Scoring of ER, PR, HER-2 and Ki-67 in Breast Carcinoma

Immunohistochemistry (IHC) plays an important role in evaluating the status of ER, PR, Ki-67 and human epidermal growth factor receptor 2 (HER-2) during diagnosis of breast cancer. Although some existing automated approaches can solve the high time-consumption and inter-/intra-observer variability drawbacks to a certain extent, most of them are can’t analyze both nuclear staining and cell membrane staining using the same method. This is attributed to the difference in localization of the positive signal of immunohistochemical staining in different biological markers. The present study proposes a novel automated image analysis model for scoring and grading of ER, PR, Ki-67 and HER-2 immunohistochemical images based on whole tissue sections in breast cancer. The scoring results of the trained model and manual interpretation of ER, PR, Ki-67 and HER-2 were then finally analyzed and compared. Experimental results show that the F1-measure was 0.8450, 0.8533 and 0.7962 for nuclear recognition of Ki-67, ER/PR and HER-2 respectively. For stain grading of Ki-67, ER/PR and HER-2, the F1-measure was 0.9776, 0.8306 and 0.9573 respectively. The scoring consistency of ER/PR, Ki-67 and HER-2 between our model and expert interpretation was 0.9279, 0.9712 and 0.8046 respectively. Our results demonstrate that artificial intelligence technology is a feasible and accurate method for accurate quantitative immunohistochemical analysis that can solve the drawbacks of low repeatability and time consumption brought by manual counting. The main contribution of our proposed model is that it can recognize both nuclear staining and cell membrane staining and grade the staining intensity as a sequential learning task.
Weed control and productivity of maize (Zea mays L.)

Field trials were conducted at the Teaching and Research Farm of Kwara State University, Malete, to determine the weed control method that will be more effective in controlling weeds and give higher grain yield and cash returns in the production of maize. The experiment consisted of 9 treatments: Primextra + Aminicome at 1.5 + 1.5 kg ha-1 (metolachlor 375 g a.i. ha-1 + atrazine 375 g a.i. ha- 1 + 2,4 - D 900 g a.i. ha-1), Primextra + Aminicome at 2.0 + 2.0 kg ha-1 (metolachlor 500 g a.i. ha-1 + atrazine 500 g a.i. ha-1 + 2,4 - D 1200 g a.i. ha-1), Primextra + Aminicome at 2.5 + 2.5 kg ha-1 (metolachlor 750 g a.i. ha-1 + atrazine 750 g a.i. ha-1 + 2,4 - D 1500 g a.i. ha-1), Primextra + Guard force at 1.5 + 0.03 kg ha-1 (metolachlor 375 g a.i. ha-1 + atrazine 375 g a.i. ha-1 + nicosulfuron 1.2 g a.i. ha-1 ), Primextra + Guard force at 2.0 + 0.05 kg ha-1 (metolachlor 500 g a.i. ha-1 + atrazine 500 g a.i. ha-1 + nicosulfuron 2.0 g a.i. ha-1), Primextra + Guard force at 2.5 + 0.07 kg ha-1 (metolachlor 750 g a.i. ha-1 + atrazine 750 g a.i. ha-1 + nicosulfuron 2.8 g a.i. ha-1), Primextra at 1.5 kg ha-1 (metolachlor 375 g a.i. ha-1 + atrazine 375 g a.i. ha-1) + one supplementary hoe weeding (SHW) at 6 weeks after sowing (WAS), two hand weedings at 3 and 6 weeks after sowing (WAS) and a weedy check. These treatments were laid out in a randomized complete block design (RCBD) with three replicates. Data collected were subjected to analysis of variance using the Statistical Analysis Software (SAS) package, after which means were separated using Duncan? s Multiple Range Test (DMRT). Results showed that treatment combinations of Primextra at 1.5 Kg ha-1 + one SHW at 6 WAS, two hoe weedings at 3 and 6 WAS, Primextra + Aminicome at 2.0 + 2.0 kg ha-1 and Primextra + Guard force at 2.0 + 0.05 kg ha-1 gave effective weed control, higher grain yield and cash returns. They are therefore recommended for application in rotation by farmers in Malete.
Structured and Consistent Multi-Layer Multi-Kernel Subtask Correction Filter Tracker

Some multi-task correlation filter trackers achieve the top-ranked performance in terms of accuracy and robustness. However, they directly fuse multiple types of features into a single kernel space. This operation fails to fully explore the discriminative strength and diversity of different features, and also ignores the structured correspondence of different tasks. To solve these issues, we propose a structured multi-kernel subtask correlation filter tracker with temporal-spatial consistency, which enjoys the merits of both layered multi-kernel subtask learning and structured correlation filter. Specifically, we firstly assign one kernel space to each channel feature. Multi-channel features correspond to multi-kernel spaces to boost their powerful discriminability. And then, we divide the target into multi-layer patches with different sizes, and regard the correlation filter trace of each patch with one channel feature as a subtask. In the following, we incorporate globally and locally structured correlation filters into a unified multi-kernel subtask particle tracking framework. The global and local subtasks complement and enhance each other with similar motion model. The proposed tracker not only exploits the cooperation and complementarity of layered multi-kernel subtask correlation filters, but also mines the underlying geometric structure of global subtasks, and the inner spatial locality correspondences of local subtasks inside the target. This operation is achieved by dual group sparsity regularized terms with mixed-norm $l_{p,q}$ , which decomposes the multi-kernel subtask filter matrix into two collaborative components. They correspond to the adaptive filter feature selection and outlier subtask detection, respectively. Besides, the developed tracking model maintains the temporal coherence and spatial consistency of multi-layer subtask filters via the smooth regularizer. Finally, the tracking formulation is optimized by the accelerated proximal gradient approach (APG). Encouraging analyses on six benchmark datasets, verify the favorable effectiveness and robustness of our method against state-of-the-art trackers.
Al-Quran Translation Parallel Corpus for the Development of Al-Quran Translation Studies in Indonesia

In the field of language studies and research, Al-Quran is often used as an object and source of primary data. In line with the dynamics in technology, data and format of conventional Al-Quran writing is converted and developed to become a digital data. Further development brings Al-Quran digital data becoming a corpus with all its variants, including parallel corpus which pairs Al-Quran texts in Arabic with its translations in non-Arab languages. This makes use and utilization of this type of data easier for the development of broader studies on Al-Quran. This study aims to describe the urgency of Al-Quran parallel corpus and its Translation in Indonesian language and local languages in the Indonesian archipelago. This study applies the descriptive method to discuss the availability of materials and data of Al-Quran translation in several local languages in the Archipelago. Furthermore, we will also describe the experimental process in preparing an initial model for the Al-Quran parallel corps and its translation in Indonesian language. The result of this study reveals that the availability of products containing materials and data of Al-Quran and its Translation in Indonesian language and local languages can be an important capital and main basis for preparation of an Al-Quran parallel corpus and its Translation for the development of Al-Quran translation studies in Indonesia. Furthermore, the result of study can be utilized to evaluate or review the methodology used for translation of Al-Quran into local languages in Indonesia. It is also important to introduce this step and continued with strategic efforts to encourage Al-Quran translation studies into local languages. This prototype of model Al-Quran parallel corpus and its Translation into Indonesian language can at least be tested through corpus processing applications available in the website of Sketch Engine.
Cristallogenese des macromolecules biologiques : influence de la nature des sels et de la temperature sur la solubilite du lysozyme et sur leds interactions proteine-proteine

Le travail de these presente dans ce memoire a consiste a: 1) etudier l'influence d'agents precipitants sur la solubilite et la cristallisation du lysozyme en utilisant une methode quantitative: la determination des courbes de solubilite. En premier lieu cette methode a ete appliquee a la recherche de composes organiques comme nouveaux agents de cristallisation. Puis l'influence de la temperature sur la solubilite a ete etudiee en mesurant les courbes de solubilite de la proteine en presence de divers sels a 0c, 18c et 40c. 2) aborder les interactions entre les ions et la proteine en mettant en evidence la fixation des ions par dialyse a l'equilibre puis en etudiant l'effet des ions sur l'activite enzymatique du lysozyme. 3) approfondir ces resultats par l'etude de l'effet des sels sur les interactions entre molecules de proteine en solutions soussaturees en utilisant la diffusion des rayons x aux petites angles. Ces resultats ont ete compares avec les effets des sels sur la solubilite
Wild Resource Diversity of Mytilus unguiculatus Reduced by Aquaculture in the Southeast China Sea

1National Engineering Research Center for Marine Aquaculture, Marine Science and Technology College, Zhejiang Ocean University, No.1 Haida South Road, Changzhi Island, Zhoushan, Zhejiang, 316022, PR. China 2Scientific Observing and Experimental Station of Fishery Resources for Key Fishing Grounds, MOA, Key Laboratory of Sustainable Utilization of Technology Research, Marine Fisheries Research Institute of Zhejiang, Zhoushan 316021, PR China 3Key Laboratory of Informatization of Habitat Monitoring and Fishery Resource Conservation Research in the East China Sea of Zhejiang Province, Zhejiang Ocean University, Zhoushan 316021, PR China Article Information Received 15 October 2019 Revised 02 January 2020 Accepted 28 January 2020 Available online 02 October 2020
Bioavailabilitas Kalsium dalam Serbuk, Ekstrak Air dan Ekstrak Pekat Daun Kelor (Moringa oleifera Lam.) pada Tikus Wistar (Rattus norvegicus)

Kalsium merupakan mineral terbanyak dalam tubuh yaitu 1,5 – 2 % dari berat badan orang dewasa. Salah satu fungsi kalsium yaitu membentuk tulang dan gigi. Kebutuhan kalsium bagi remaja dan dewasa berkisar 1.000 – 1.200 mg/hari. Namun asupan kalsium harian orang Indonesia masih seperempat dari jumlah tersebut. Kekurangan kalsium ini menyebabkan peningkatan penderita osteoporosis dan stunting yang setiap tahun. Susu terkenal sebagai sumber kalsium yang baik. Namun, harga mahal dan penyakit lactose intolerance membatasi konsumsi susu. Daun kelor (Moringa oleifera) mengandung kalsium sebesar 185 mg/100 g berat basah, berpotensi menjadi alternatif pengganti susu. Akan tetapi, kandungan oksalat daun kelor dapat mengurangi bioavailabilitas kalsium. Bentuk sediaan suplemen daun kelor seperti serbuk, ekstrak air dan ekstrak pekat dapat memiliki bioavailabilitas kalsium yang berbeda. Tujuan penelitian ini yaitu membandingkan pengaruh perbedaan bentuk sediaan suplemen daun kelor sebagai sumber kalsium terhadap bioavailabilitas kalsium pada tikus wistar. Penelitian ini menggunakan metode RAL (Rancangan Acak Lengkap) yang terdiri dari 5 kelompok perlakuan. Tikus dipilih random untuk dikelompokkan sebagai berikut: kontrol (diet normal tanpa suplemen), perlakuan 1 (diet normal + serbuk daun kelor), perlakuan 2 (diet normal + ekstrak air daun kelor), perlakuan 3 (diet normal + ekstrak pekat daun kelor dosis 1) dan perlakuan 4 (diet normal + ekstrak pekat daun kelor dosis 2). Intervensi selama 64 hari untuk mendepositkan kalsium dalam tulang. Hari ke- 65, tikus dianasthesi dan dibedah, tulang femur diambil untuk dianalisis kadar kalsium menggunakan AAS. Hasil penelitian menunjukkan bahwa bentuk sediaan suplemen daun kelor berpengaruh nyata terhadap asupan kalsium, deposit kalsium di tulang femur, dan bioavailabilitas kalsium. Tetapi tidak berpengaruh nyata terhadap konsumsi pakan, berat badan tikus, panjang dan berat tulang femur serta kadar abu tulang femur tikus wistar. Kadar kalsium sediaan daun kelor: serbuk 155,5 ppm, ekstrak air 96,68 ppm, dan ekstrak pekat 131,3 ppm. Kadar oksalat: serbuk sebanyak 1.987 mg/100 g, ekstrak air sebanyak 7,93 mg/100 g, dan ekstrak pekat sebanyak 1 mg/100 g. Nilai bioavailabilitas kalsium serbuk 4,7%, ekstrak air 5,2%, ekstrak pekat dosis 1 6,9% dan ekstrak pekat dosis 2 7,3%.
Facilitators of informal learning in the workplace: the case of two cooperatives in the machine tool sector

In recent years, interest in informal learning in the workplace has intensified, with organizations being concerned about ways through which workers learn in the workplace beyond the knowledge acquired through formal learning. Every day at the workplace, a series of lessons can be learnt through colleague interaction, in addition to another series of elements that act as a catalyst to enhance workers’ learning and knowledge. A qualitative approximation method was selected for this study. Furthermore, 16 in-depth interviews were conducted with employees with different responsibilities and from different organizational areas. The study results describe the manner in which learning occurs in the workplace and employees’ perception of different elements that act as catalysts to enhance their learning. While numerous elements specific to the job position held by employees are indicated, learning in the workplace responds to a model based on three pillars: a flexible worker with skills to perform tasks requiring constant adaptation to respond to unexpected events and problem solving; an organization that provides spaces for interaction, such as team meetings, to address difficulties; and a competitive environment marked by technological innovation and customer demand that fosters learning.
Dynamics of Promoted Gas-Solid Fluidized Bed using SecondaryFluidizing Medium

Many thermal power generating units are, of late, increasingly following the concept of circulating fluidized bed, and using secondary air in the fluidizer for the improvement of quality of fluidization and combustion, of course without understanding the real hydro-dynamics involved. Owing to the scarcity of good quality of coal and an ever-increasing demand for electricity for the complete combustion of low grade coal, the introduction of secondary air is one of the best solutions. Several sponge iron production units have been entangled with the problem of converting carbon into carbon dioxide.Extensive experimental work and industrial applications provide unambiguous evidence that it is precisely these fluctuations that are responsible for extremely high values of effective coefficients of heat and mass transport to determine the dynamic properties of disperse mixtures. In general, large scale fluctuations strongly depend on various external conditions such as geometric properties of the disperse flow and quality of the gas distribution in fluidized beds. Whereas the small scale fluctuations depend merely on the local hydrodynamic situations and more inherent to macroscopically uniform states with no inner circulation and bubbles.
Revision of failed hip resurfacing arthroplasty to total hip arthroplasty-a case series and review of literature

Background: Revision rate of hip resurfacing in most national registries nearly 3.5%. Conversion to total hip replacement may be the correct option for those whose activity levels changed and the need for hip resurfacing no longer required. Purpose: Assessing outcomes of failed hip resurfacing to total hip arthroplasty. Primary outcomes included improvement of Oxford, WOMAC, Harris, and UCLA hip scores. Secondary outcomes included surgical site infection, residual groin pain, and heterotopic ossification. Study design: Prospective case series. Level of evidence: Level IV. Patients and Methods: 25 patients underwent revision hip resurfacing to total hip arthroplasty. Mean age 56.8 years. Indications for revision: femoral neck fractures (10 cases), femoral neck thinning (3 cases), component loosening (4 cases) component dislocation (2 cases) persistent groin pain, and clicking (3 cases) and component wear (3 cases). Nineteen patients revised both components and six revised femoral components only. Results: Average duration of follow up 26.8 months (28-48 months) and the procedure was successful in 23 (92%) patients. Preoperative Oxford, WOMAC, Harris, and UCLA hip scores were 21.3, 78.3, 35,7, and 2 respectively improved to 39.8, 11.1, 92.3, and 7 respectively at last follow-up representing statistically significant improvements (p<0.0001) for each score 3 cases (12%) with complications; surgical site infection (1 case), residual groin pain (1 case), and mild heterotopic ossification (1 case). Conclusion: Conversion of hip resurfacing to THA has high satisfaction rates. These results compare favorably with those for revision total hip arthroplasty. Keywords hip resurfacing arthroplasty, total hip arthroplasty, femoral neck fractures, component loosening
Perfil de prescrição de psicotrópicos em uma unidade básica de saúde do Paraná

The prescription of psychotropics for the treatment of psychiatric disorders or emotional distress seems to be a common practice in Primary Care, and its prolonged and abusive use can compromise the individual's health. This study aimed to analyze the prescription of psychotropic drugs for users of Primary Care, through the analysis of medical records. This is a documentary study with a sample of 130 records analyzed in a Basic Health Unit in Paraná. The medical records of users over 18 years of age, with prescriptions of psychotropic drugs, were selected from January 2018 to July 2019. As for the sociodemographic profile, the sample was predominantly female, most of whom live with a partner and have a low level of education. , the expressive consumption occurred in the elderly population, with non-formal professional predominance, housewives. Among the antidepressants the most used was Fluoxetine. As for the diagnosis of pathologies, most were not related to the diagnosis of mental disorders and few patients were referred to the specialized service. Drug therapy is the main strategy for treating symptoms and diseases.
Genetic Characterization of Paracentrotus lividus (Lamarck, 1816) Populations from Nw Spain and the Canary Islands

ABSTRACT The sea urchin Paracentrotus lividus is the most commercially important sea urchin species harvested in the NE Atlantic and Mediterranean coasts. To improve the management of P. lividus natural stock and its commercial exploitation, the population genetic structure of P. lividus in the Northeast Atlantic coast has been characterized. Populations from three regions of Spain: Asturias, Galicia, and the Canary Islands were sampled, and a 700-bp fragment of the mitochondrial gene cytochrome c oxidase subunit I (COI) was sequenced. The obtained sequences were combined with previously available haplotypes coming from 127 sea urchins from the Canary Islands and the Mediterranean and Atlantic coasts of Spain—they collapsed in 54 haplotypes with 43 polymorphic sites—and 13 of these haplotypes were provided for the obtained sequences. The haplotype network shows high haplotype diversity and low nucleotide diversity values in all the studied populations. The distribution of analyzed haplotypes shows a high genetic homogeneity among populations. With the obtained data, no significant genetic differentiation could be found among populations analyzed in Galicia, Asturias, and the Canary Islands, and the existence of a population structure in this geographical area could not be determined. Based on this study, there would be no loss of genetic variability if the shores of the Canary Islands were repopulated with urchins from the Iberian Peninsula, although it is recommended to repopulate overexploited areas with urchins from the same zone until the study is extended with other molecular markers.
Psychiatry and HIV: A retrospective study for four years

There is a complex relationship between HIV infection and psychiatric disorders. Being HIV infected could result in psychiatric disorders as a result of psychological consequence or because of the effect of the virus on the brain. Patients with severe mental illness are thought to be at increased risk of acquiring HIV infection. This could be attributed to several characteristics of certain subgroups of psychiatric patients, including having a substance- related disorder (particularly intravenous drug use), being single or divorced, practicing risky sexual behavior, and having reduced awareness about the modes of transmission of infectious diseases and of relevant protective measures. Aim of the study is to see the prevalence of HIV infection among psychiatric patients and to evaluate the risk factors of acquiring infection. This study retrospectively assessed the seroprevalence of HIV infection among psychiatric patients who were referred for laboratory testing over a period extending from September 2011 to August 2015. A total of 2477 patients were referred for laboratory testing, out of which 06 (0.24%) were found to be seropositive. Out of the 06 cases 04 (66.67%) were found to be having substance- related disorder. 04 patients were diagnosed to be having Schizophrenia and one patient with Unspecified nonorganic psychosis. Risk reduction methods used elsewhere may not be effective among these patients. Severe psychiatric and cognitive impairments affect their ability to adopt new behaviors; extreme social deprivations constrain their options for sex and influence patterns of drug use; and sensitive outreach is required to ensure their participation in any formal program. Though the prevalence of HIV is low among psychiatric patients, still new intervention strategies in this section of the population is needed.
Hyperbaric oxygenation therapy for treating complicated COVID-19: first experience

Highly virulent SARS-CoV-2 emerged in Wuhan, China, and rapidly spread across the globe afflicting 14.5 million and killing over 600,000 people. The key factors affecting the severity of COVID-19 include advanced age and respiratory failure requiring mechanical ventilation (MV). Mortality rates estimated for mechanically ventilated patients with SARS-CoV-2-induced respiratory failure are 76.4% in the 18-65 age group and 97.2% in individuals over 65 years. At present, extracorporeal membrane oxygenation (ECMO) remains a life-saving method of choice. It is essentially a lung bypass system for direct oxygenation of the blood. It is an invasive and costly procedure performed only at specialized medical care facilities. China, USA, Germany, France and Israel have already launched large-scale research and clinical studies of non-invasive approaches to improving the efficacy of oxygen therapy in patients with complicated viral pneumonia, such as hyperbaric oxygen therapy (HBOT). HBOT is a well-established treatment for anaerobic and aerobic infections accompanied by soft tissue necrosis, carbon monoxide poisoning, stubborn wounds, including non-healing diabetic ulcers, complications of radiation therapy, stroke sequelae, brain injuries, decompression sickness, and other conditions. The use of HBTO in patients with viral infection, pulmonary edema and pneumonia is supported by the laws of physics and clinical/physiological effects in response to the exposure of elevated air pressure and hyperoxic environment. This review provides rationale for using hyperbaric oxygenation therapy in patients with SARS-CoV-2-induced viral pneumonia and presents the first data on the beneficial effects of HBTO in Chinese patients with COVID-19 complications.