Miracle-dz/UniFAR-FTUs huggingface dataset:
Protein kinase C epsilon activation regulates proliferation, migration, and epithelial to mesenchymal-like transition in rat Schwann cells

Introduction Protein kinase type C-ε (PKCε) plays an important role in the sensitization of primary afferent nociceptors, promoting mechanical hyperalgesia. In accordance, we showed that PKCε is present in sensory neurons of the peripheral nervous system (PNS), participating in the control of pain onset and chronification. Recently, it was found that PKCε is also implicated in the control of cell proliferation, promoting mitogenesis and metastatic invasion in some types of cancer. However, its role in the main glial cell of the PNS, the Schwann cells (SCs), was still not investigated. Methods Rat primary SCs culture were treated with different pharmacologic approaches, including the PKCε agonist dicyclopropyl-linoleic acid (DCP-LA) 500 nM, the human recombinant brain derived neurotrophic factor (BDNF) 1 nM and the TrkB receptor antagonist cyclotraxin B 10 nM. The proliferation (by cell count), the migration (by scratch test and Boyden assay) as well as some markers of SCs differentiation and epithelial-mesenchymal transition (EMT) process (by qRT-PCR and western blot) were analyzed. Results Overall, we found that PKCε is constitutively expressed in SCs, where it is likely involved in the switch from the proliferative toward the differentiated state. Indeed, we demonstrated that PKCε activation regulates SCs proliferation, increases their migration, and the expression of some markers (e.g., glycoprotein P0 and the transcription factor Krox20) of SCs differentiation. Through an autocrine mechanism, BDNF activates TrkB receptor, and controls SCs proliferation via PKCε. Importantly, PKCε activation likely promoted a partial EMT process in SCs. Discussion PKCε mediates relevant actions in the neuronal and glial compartment of the PNS. In particular, we posit a novel function for PKCε in the transformation of SCs, assuming a role in the mechanisms controlling SCs' fate and plasticity.
Concircular helices and concircular surfaces in Euclidean 3-space R^3

Given a submanifold $M\subset R^{n}$ and a concircular vector field $Y\in Con(R^{n})$, $M$ is said to be a concircular submanifold (with axis $Y$) if $\langle N,Y\rangle$ is a constant function along $M$, $N$ being any unit vector field in the first normal space. In this paper we characterize concircular helices in $R^3$ by means of a differential equation involving their curvature and torsion. We find a full description of concircular surfaces in $R^3$ as a special family of ruled surfaces, and we show that $M\subset R^{3}$ is a proper concircular surface if and only if either $M$ is parallel to a conical surface or $M$ is the normal surface to a spherical curve. Finally, we characterize the concircular helices as geodesics of concircular surfaces.
Relational Edge-Node Graph Attention Network for Classification of Micro-Expressions

Facial micro-expressions (MEs) refer to subtle, transient, and involuntary muscle movements expressing a person’s true feelings. This paper presents a novel two-stream relational edge-node graph attention network-based approach to classify MEs in a video by selecting the high-intensity frames and edge-node features that can provide valuable information about the relationship between nodes and structural information in a graph structure. The paper examines the impact of different edge-node features and their relationships on the graphs. The first step involves extracting high-intensity-emotion frames from the video using optical flow. Second, node feature embeddings are calculated using the node location coordinate features and the patch size information of the optical flow across each node location. Additionally, we obtain the global and local structural similarity score using the jaccard’s similarity score and radial basis function as the edge features. Third, a self-attention graph pooling layer helps to remove the nodes with lower attention scores based on the top-k selection. As the final step, the network employs a two-stream edge-node graph attention network that focuses on finding correlations among the edge and node features, such as landmark coordinates, optical flow, and global and local edge features. A three-frame graph structure is designed to obtain spatiotemporal information. For 3 and 5 expression classes, the results are compared for SMIC and CASME II databases.
Importance-performance analysis in fitness apps. A study from the viewpoint of gender and age

Background We are currently undergoing a profound process of digital transformation that has favoured the development and use of apps in multiple facets of people’s daily lives. In the fitness industry, this situation has facilitated the control of exercise and the maintenance of healthier lifestyles. However, it is not known how the perceived quality and importance of fitness apps vary for users based on gender and age, which is the objective of this study conducted among users of fitness centres. Methods By means of a convenience sample, 321 users from different centres of the boutique fitness chain Sano Centre (238 females and 83 males) took part in the study. They answered the 16 items of the MARS scale, distributed in four dimensions, in terms of importance and perceived quality. The existence of significant differences was analysed using non-parametrical statistics such as the U-Mann-Whitney (gender) and the H-Kruskal-Wallis (age). In addition, a cluster analysis, combining hierarchical and non-hierarchical methods, was analysed considering as a dependent variable the level of recommendation of fitness apps. Results Considering gender, in importance-performance analysis (IPA), credibility was the most important attribute for females and quality of information for males. In the case of age, credibility was the most important attribute in all the ranges. The cluster analysis established two groups (high and low recommendations of the fitness app). In importance, the first group scored better on all factors except entertainment and interest. In valuation, the scores were lower than on importance, especially in the low recommendation group. Conclusion Regarding usage behaviour, credibility is the factor to which users attach the highest importance and rating, regardless of gender and age. The main demand focuses on improving the gestural design and visual appeal, which will facilitate a better user experience.
Effects of the Coculture Initiation Method on the Production of Secondary Metabolites in Bioreactor Cocultures of Penicillium rubens and Streptomyces rimosus

Bioreactor cocultures involving Penicillium rubens and Streptomyces rimosus were investigated with regard to secondary metabolite production, morphological development, dissolved oxygen levels, and carbon substrate utilization. The production profiles of 22 secondary metabolites were analyzed, including penicillin G and oxytetracycline. Three inoculation approaches were tested, i.e., the simultaneous inoculation of P. rubens with S. rimosus and the inoculation of S. rimosus delayed by 24 or 48 h relative to P. rubens. The delayed inoculation of S. rimosus into the P. rubens culture did not prevent the actinomycete from proliferating and displaying its biosynthetic repertoire. Although a period of prolonged adaptation was needed, S. rimosus exhibited growth and the production of secondary metabolites regardless of the chosen delay period (24 or 48 h). This promising method of coculture initiation resulted in increased levels of metabolites tentatively identified as rimocidin B, 2-methylthio-cis-zeatin, chrysogine, benzylpenicilloic acid, and preaustinoid D relative to the values recorded for the monocultures. This study demonstrates the usefulness of the delayed inoculation approach in uncovering the metabolic landscape of filamentous microorganisms and altering the levels of secondary metabolites.
Modelling rainfall erosivity using the Weather Research and Forecasting model

Soil erosion is a serious threat to agricultural productivity and the sustainable provision of food to a growing world population. Current erosion models employ simplistic treatments of rainfall. This thesis presents a new approach to erosion modelling, using the Weather Research and Forecasting model to simulate rainfall erosivity, an indicator of the erosive capacity of rain. Rainfall erosivity is modelled in the Caucasus region, an area vulnerable to erosion and climate change pressures. Low intensity rainfall (below 2mmhr−1) is found to contribute significantly to erosivity (23%), contrary to common assumptions. An exponential dependence of the fraction of erosivity from light rain on the proportion of light rain is found. Erosion models focus on storms, but results suggest that storm-based calculations may exclude up to 30% of erosivity. In the Universal Soil Loss Equation, this does not lead to errors in long term soil loss but could cause an underestimation of event erosion. Rainfall kinetic energy flux is an important variable in erosion prediction and is routinely parameterised from intensity. Here this is dynamically simulated from basic physics in a cloud resolving model, using four microphysics schemes. Results are within the range of observations and capture the observed variability in kinetic energy for a given intensity, where current methods fail. Large raindrops are shown to contribute disproportionately to total kinetic energy, and also to surface precipitation, compared with their number. No connection has hitherto been drawn between aerosols and soil erosion. The effect of aerosols on rainfall erosivity is investigated in a cloud resolving model. Aerosols can either enhance or suppress precipitation. In both these cases the response of erosivity to a rise in aerosols is in the same direction as, but amplified beyond, the change in total rain. It is also shown that aerosols can influence erosivity by changing raindrop sizes. These results suggest that anthropogenic aerosol emissions affect erosivity and thus may have important consequences for agricultural productivity.
The Society for Cardiovascular Angiography and Interventions

PCT No. PCT/NO95/00105 Sec. 371 Date Dec. 12, 1996 Sec. 102(e) Date Dec. 12, 1996 PCT Filed Jun. 16, 1995 PCT Pub. No. WO95/34467 PCT Pub. Date Dec. 21, 1995A water jet propulsion unit for a waterborne craft comprising a propeller pump having a pump housing outside the outlet opening of which there is provided a steering portion which makes possible the turning of the vessel as well as the retarding and reversing thereof. The steering portion includes a support bearing structure mounted at the outlet opening to be swung about a vertical axis designed to have two parallel side plates between which a steering nozzle is pivotally mounted about a horizontal axis. Below the steering nozzle, designed to have a rectangular cross section and between the two side plates, a reversing bucket is pivotally mounted. This reversing bucket is link connected to the steering nozzle so that when the fore end of the steering nozzle is swung upwards, it will swing from a position up under the steering nozzle to a downwardly swung position.
Cognitive and Practice-based Theories of Organizational Knowledge and Learning: Incompatible or Complementary?

Cognitive and practice-based approaches to organizational knowledge and learning are typically portrayed as incommensurable, with the result that there has been little positive dialogue between the two traditions. This article argues that the incompatibility of the two sets of approaches has been overstated and that there is actually much that each can learn from the other. Cognitive approaches, which have often been accused of offering an effectively individualized, static and representationalist understanding of organizational knowledge, can benefit from taking on board the practice-based view of knowledge as historically, culturally and socially situated. However, the article also suggests that practice-based theories would do well to draw insights from cognitive approaches, particularly regarding the role of cognitive frameworks or schemas in guiding knowledge processes. To provide an example of how cognitive and practice-based approaches can be integrated, the latter part of the article offers an empirical illustration of how a team of consulting engineers represent and perform alternative schemas of project work through their day-to-day practices.
A Map of Invasive Annual Grasses in Nevada Derived from Multitemporal Landsat 5 TM Imagery

Summary Invasive annual grasses are an ecological catastrophe that we must contend with. The Nevada Natural Heritage Program has developed geographically explicit statistical models and mapped annual grass distribution over the state of Nevada. The models and final map were developed from 806 training sites sampled on the ground, remotely sensed data for two seasons from Landsat 5 TM and MODIS satellite sensors, and accessory geographic data. Accuracy of the final map was analyzed from three independent data sets: Southwest Regional Gap Analysis Project (REGAP) training data (15,318 plots); California Department of Fish and Game vegetation plots from the Mono Lake area (178 plots); and from the Mojave region (939 plots). Data from the Mono area had sparse annual grass cover, therefore summary statistics from that data set may not be appropriate. However, the landscape-level distribution of annual grasses in the plots corresponded reasonably well to the distribution of annual grass in our final map. Root-Mean-Square-Error (RMSE) from the REGAP data was 10.33 %; 75 percent of predictions for gap plots were off by 5 % or less; and 95 percent of predictions were off by 21 % or less. For the Mojave data set, RMSE was 7.48 %; 75 % of predictions were off by 9 % or less; and 95 % of predictions are off by 15 % or less. Accuracy assessment on REGAP data, as well as review of predictions for training data plots, suggest that annual grasses are generally underestimated for sites with high density of annual grasses. Although data were collected that suggest inter-annual variation in the north does not necessarily result in greater cover after wet winters, assessment with Mojave data does reveal strong inter-annual variation in annual grass cover for that region. Due to both the underestimated values for high-density annual grass stands, and the recognition of inter-annual variation, it is recommended that the map presented here be interpreted as an annual grass index (ANGRIN) map, rather than an estimate of actual annual grass cover. Nevertheless, the ANGRIN map clearly reveals the pattern of annual grass invasion across Nevada.
INTRODUÇÃO DA ALIMENTAÇÃO COMPLEMENTAR EM CRIANÇAS MENORES DE UM ANO: VIVÊNCIA E PRÁTICA DE MÃES

Este estudo objetivou identificar o periodo de amamentacao e de introducao da alimentacao complementar e descrever a forma de introducao dessa alimentacao em criancas de seis a 11 meses e 29 dias de vida. Estudo descritivo, quantitativo, transversal com participacao de 43 maes. Os dados foram coletados utilizando-se um instrumento estruturado contendo informacoes sociodemograficas e sobre a alimentacao infantil. Em relacao ao aleitamento materno, 95,3% relataram realiza-lo, sendo que 51,2% realizaram o aleitamento exclusivo ate os seis meses. Quanto a alimentacao complementar, 67,4% iniciaram aos seis meses; 27,9%, antes dos seis meses; e 4,7%, apos os seis meses. Em 58,1% das criancas, o leite materno foi mantido apos o inicio da alimentacao complementar. Constatou-se que o aleitamento materno vem sendo praticado, mas sua oferta de forma exclusiva ate os seis meses de idade ainda nao e frequente. A introducao da alimentacao complementar nao vem sendo realizada como se recomenda.
Cultivation Strategies of Kenaf (Hibiscus cannabinus L.) as a Future Approach in Malaysian Agriculture Industry

In recent years, kenaf has gained significant global attention as a more cost-effective, adaptable, and manageable alternative to other fibre crops. India and China, with nearly 70% of the global kenaf production, have emerged as the leading producers of kenaf plants. While kenaf was traditionally valued for its paper production, it has evolved into a multipurpose crop with diverse industrial applications over the past two decades. Conventional soil-based cultivation methods for kenaf require up to six months for plant maturity. However, in vitro propagation techniques offer a promising alternative that enables faster growth and reduced labour costs. In vitro propagation can be achieved using solid and liquid media, with limited research available on the pure liquid culture method for kenaf. This review aims to introduce and compare the production of kenaf using solid and liquid media, with a specific focus on the emerging country of Malaysia, which seeks to harness the potential of kenaf cultivation for the 15th Sustainable Development Goal, “life on land”, and its contribution to the economy.
Regional Variation in the Material Culture of Hunter Gatherers: Social and Ecological Approaches to Ethnographic Objects from Queensland, Australia

The region of Queensland is divided into six areas through drainage divisions, something which Anne Best shows to correlate with stylistic differences in objects used by modern hunter-gatherers. This largely unrevised thesis studies six categories of object (bags, boomerangs, message sticks, shields, spears and spearthrowers), 813 artefacts in total, plus secondary sources, for their spatial organisation and stylistic properties. In the hope of finding a model for which archaeologists can study past hunter-gatherers, she illustrates how, in this instance, stylistic changes aline with drainage divisions and goes on to assess the social role of style and the environmental factors that may have played a significant role.
Association of coffee consumption in metabolic syndrome: a cross-sectional and Mendelian randomization study in UK Biobank

Objective: To investigate the associations between coffee consumption and metabolic syndrome and its component conditions, as well as the effect of using milk, sugar, and artificial sweetener on these associations. Research Design and Methods: The cross-sectional analysis included 351,805 participants from the UK Biobank. Coffee consumption data was obtained using food frequency questionnaire and 24-hour recall and metabolic syndrome was ascertained based on blood biochemistry results and self-reported medication use. Odds ratios were calculated using multivariable logistic regression adjusted for lifestyle and socioeconomic factors, with verification using two-sample Mendelian randomization. Results: Coffee consumption up to 2 cups per day was inversely associated with metabolic syndrome (1 cup/day, OR: 0.88, 95% CI: 0.85, 0.92; 2 cups/day, OR: 0.90, 95% CI: 0.86, 0.93) while associations at higher intakes were near null. Mendelian randomization did not support a causal association between coffee intake and metabolic syndrome. Both self-reported and genetically predicted high coffee consumption (4 cups per day or more) were associated with central obesity. The inverse association between coffee consumption and metabolic syndrome was more profound among drinkers of ground coffee than those of instant coffee. Results were similar when stratified by the use of milk and sugar, yet the use of artificial sweetener with coffee was positively associated with metabolic syndrome and all component conditions. Conclusions: Coffee consumption likely increase the risk of central obesity but unlikely impact risk of metabolic syndrome. The possible health effect of using artificial sweetener with coffee warrant investigations in future studies.
The P Factor Outweighs the Specific Internalizing Factor in Predicting Recurrences of Adolescent Depression

Background: The early prediction of adolescent depression recurrence poses a significant challenge in the field. This study aims to investigate and compare the abilities of two psychopathology factors, namely the general psychopathology factor (p) and the specific internalizing factor, in predicting depression recurrence over a 2-year course, as well as identifying remitted depression patients from healthy adolescents. Longitudinal changes of these two factors in different trajectory groups were also tracked to examine their sensitivity to sustained remission and relapse. Methods: We included 255 baseline-remitted depression patients and a healthy control group (n=255) matched in age, sex, and race, sourced from the Adolescent Brain Cognitive Development Study. The Linear Mixed Model was employed to differentiate between healthy controls and remitted depression patients, predict depression recurrence, and track longitudinal changes over a subsequent 2-year course using the p factor and the specific internalizing factor respectively. Results: The p factor not only effectively discriminated between remitted depression patients and healthy controls, but also robustly predicted the depression recurrence over a subsequent 2-year course. The specific internalizing factor could only differentiate remitted depression patients from healthy controls. Additionally, a noteworthy longitudinal decline of the p factor in the sustained-remission group was observed. Conclusions: Psychopathology factors serve as the inherent and enduring measurement of long-term mental health aberrations. Longitudinal results indicate that the p factor is more sensitive to respond to sustained remission than the internalizing factor. The ability of the overall p factor to anticipate depression relapse, unlike the specific internalizing factor, suggests clinical interventions should monitor and mitigate the coincident symptoms across all dimensions to preempt relapse of adolescent depression, rather than an exclusive focus on internalizing symptoms.
Walking the Cultural Distance: In search of direction beyond Friction

What we know is that the concept of cultural distance is frequently used, hotly debated and for many intuitively appealing. Suffering from a series of illusionary properties, it is argued to have outlived its usefulness. What we need to know is how to conceptualize the complexity of culture as a multi-dimensional, multi-level concept, taking context into account to measure quality rather than quantity (or distance). It is our ambition to do justice to the idea that cultural diversity not only leads to friction or problem creation, but also to enrichment and to generation of solutions. We discuss cultural conceptualizations and suggest cultural profiling and cultural positioning as alternative ways of comparing and contrasting critical cultural differences.