Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinicopathological and immunohistochemical features of lung invasive mucinous adenocarcinoma based on computed tomography findings

Background We performed an analysis to clarify differences in clinicopathological and molecular features of lung invasive mucinous adenocarcinoma (IMA) based on computed tomography (CT) findings and their impact on prognosis. Patients and methods On the basis of CT findings, we divided lung IMA into three subtypes: solid, bubbling, and pneumonic. We then investigated differences in clinicopathological characteristics, prognosis, and the expressions of well-identified biomarkers, including cyclooxygenase-2 (Cox-2), excision repair cross-complementation group 1 (ERCC1), ribonucleotide reductase M1 (RRM1), class III beta-tubulin, thymidylate synthase (TS), secreted protein acidic and rich in cysteine (SPARC), programmed cell death-1 ligand-1 (PD-L1), and epidermal growth factor receptor mutation, among the three subtypes. Results A total of 29 patients with resected lung IMA were analyzed. Compared with the solid or bubbling type, the pneumonic type had a higher proportion of symptoms, a larger tumor size, a higher pathological stage, and a significantly worse prognosis. The immunohistochemical findings tended to show high expression of RRM1, class III beta-tubulin, and Cox-2 in the tumor and of SPARC in the stroma, but not of ERCC1, TS, and PD-L1 in the tumor. None of the biomarkers with high expression levels in the tumor were prognostic biomarkers, but the expression of SPARC in the stroma was correlated with a poor outcome. Conclusion Clinical and pathological features, in conjunction with molecular data, indicate that IMA should be divided into different subgroups. In our results, the pneumonic type was correlated with a significantly worse outcome. Further studies should be performed to confirm our conclusion and to explore its molecular implications.
Lasing dynamics of very long (13.5mm) tapered laser emitting at 975 nm

Mode-locked semiconductor laser technology is a promising technology candidate considered by European Space Agency (ESA) for optical metrology systems and other space applications in the context of high-precision optical metrology, in particular for High Accuracy Absolute Long Distance Measurement. For these applications, we have designed, realized and characterized a multi-section monolithic-cavity tapered laser diode with a record cavity length of 13.5mm. The laser operates at 975nm wavelength with average output power up to 600mW. It is based on a MOVPE grown laser structure with Aluminium free active region enabling high optical gain, low internal losses and low series resistance. It reaches passive mode-locking operation on fundamental cavity round trip frequency of 2.88GHz with chirped pulse width of 6.2ps and time bandwidth product of 8 for the average output power of 250mW. Alongside with passive mode-locking operation, we discuss other lasing regimes in these very long tapered lasers.
Absolute dimensions of eclipsing binaries. I.

Context. The study of detached eclipsing binaries which are members of stellar clusters is is a powerful way of determining the properties of the cluster and of constraining the physical ingredients of theoretical stellar evolutionary models. Aims. DW Carinae is a close but detached early B-type eclipsing binary in the young open cluster Collinder 228. We have measured accurate physical properties of the components of DW Car (masses and radii to 1%, effective temperatures to 0.02 dex) and used these to derive the age, metallicity and distance of Collinder 228. Methods. The rotational velocities of both components of DW Car are high, so we have investigated the performance of doubleGaussian fitting, one- and two-dimensional cross-correlation and spectral disentangling for deriving spectroscopic radial velocites in the presence of strong line blending. Gaussian and cross-correlation analyses require substantial corrections for the effects of line blending, which are only partially successful for cross-correlation. Spectral disentangling is to be preferred because it does not assume anything about the shapes of spectral lines, and is not significantly affected by blending. However, it suffers from a proliferation of local minima in the least-squares fit. We show that the most reliable radial velocities are obtained using spectral disentangling constrained by the results of Gaussian fitting. Complete Stromgren uvby light curves have been obtained and accurate radii have been measured from them by modelling the light curves using the Wilson-Devinney program. This procedure also suffers from the presence of many local minima in parameter space, so we have constrained the solution using an accurate spectroscopic light ratio. The effective temperatures and reddening of the system have been found from Stromgren photometric calibrations. ±±±±
Sensitivity Analysis of Partial Differential Equations With Applications to Fluid Flow

For over 100 years, researchers have attempted to predict transition to turbulence in fluid flows by analyzing the spectrum of the linearized Navier-Stokes equations. However, for many simple flows, this approach has failed to match experimental results. Recently, new scenarios for transition have been proposed that are based on the non-normality of the linearized operator. These new “mostly linear” theories have increased our understanding of the transition process, but the role of nonlinearity has not been explored. The main goal of this work is to begin to study the role of nonlinearity in transition. We use model problems to illustrate that small unmodeled disturbances can cause transition through movement or bifurcation of equilibria. We also demonstrate that small wall roughness can lead to transition by causing the linearized system to become unstable. Sensitivity methods are used to obtain important information about the disturbed problem and to illustrate that it is possible to have a precursor to predict transition. Finally, we apply linear feedback control to the model problems to illustrate the power of feedback to delay transition and even relaminarize fully developed chaotic flows. This research was supported in part by the Air Force Office of Scientific Research under grant F49620-03-1-0243 and by the DARPA Special Projects Office.
Change analysis of a dynamic copula for measuring dependence in multivariate financial data

This paper proposes a new approach to measure dependencies in multivariate financial data. Data in finance and insurance often cover a long time period. Therefore, the economic factors may induce some changes within the dependence structure. Recently, two methods have been proposed using copulas to analyse such changes. The first approach investigates changes within the parameters of the copula. The second determines the sequence of copulas using moving windows. In this paper we take into account the non-stationarity of the data and analyse the impact of (1) time-varying parameters for a copula family, and (2) the sequence of copulas, on the computations of the VaR and ES measures. We propose tests based on conditional copulas and the goodness-of-fit to decide the type of change, and further give the corresponding change analysis. We illustrate our approach using the Standard & Poor 500 and Nasdaq indices in order to compute risk measures using the two previous methods.
Efficient Turbulence Modeling for CFD Wake Simulations

Wind turbine wakes can cause 10-20% annual energy losses in wind farms, and wake turbulence can decrease the lifetime of wind turbine blades. One way of estimating these effects is the use of computational fluid dynamics (CFD) to simulate wind turbines wakes in the atmospheric boundary layer. Since this flow is in the high Reynolds number regime, it is mainly dictated by turbulence. As a result, the turbulence modeling in CFD dominates the wake characteristics, especially in Reynolds-averaged Navier-Stokes (RANS). The present work is dedicated to study and develop RANS-based turbulence models, that can accurately and efficiently simulate wind turbine wakes. The linear k-ε eddy viscosity model (EVM) is a popular turbulence model in RANS; however, it underpredicts the velocity wake deficit and cannot predict the anisotropic Reynolds-stresses in the wake. In the current work, nonlinear eddy viscosity models (NLEVM) are applied to wind turbine wakes. NLEVMs can model anisotropic turbulence through a nonlinear stress-strain relation, and they can improve the velocity deficit by the use of a variable eddy viscosity coefficient, that delays the wake recovery. Unfortunately, all tested NLEVMs show numerically unstable behavior for fine grids, which inhibits a grid dependency study for numerical verification. Therefore, a simpler EVM is proposed, labeled as the k-εfP EVM, that has a linear stress-strain relation, but still has a variable eddy viscosity coefficient. The k-εfP EVM is numerically verified with a grid dependency study. With respect to the standard k-ε EVM, the k-εfP EVM compares better with measurements of the velocity deficit, especially in the near wake, which translates to improved power deficits of the first wind turbines in a row. When the CFD metholody is applied to a large wind farm, the simulated results cannot be compared directly with wind farm measurements that have a high uncertainty in the measured reference wind direction. When this uncertainty is used to post-process the CFD results, a fairer comparison with measurements is achieved. The thesis is submitted to the Danish Technical University in partial fulfillment of the requirements for the PhD degree. DTU PhD-0047(EN) December 2014 ISBN 978-87-93278-31-8 Sponsorship: The Center for Computational Wind Turbine Aerodynamics and Atmospheric Turbulence, funded by the Danish Council for Strategic Research (grant number 09-067216) Pages: 136 References: 81 Figures: 57 Tables: 22 Department of Wind Energy Technical University of Denmark Risø Campus, 118 Frederiksborgvej 399 DK-4000 Roskilde Denmark Telephone: +45 24921678 plaa@dtu.dk www.vindenergi. dtu.dk
Ostracism: The making of the ignored and excluded mind

This chapter explores the powerful consequences of ostracism — being ignored and excluded — at the neurophysiological, emotional, cognitive and behavioral levels. Once ostracized, individuals first recoil in pain, then perceive and respond to their social environments differently, leading them to interpret and attend to particular information that may help them cope, or often, that may perpetuate their state of exclusion. We will discuss the nature and antecedents of adaptive and maladaptive reactions to ostracism. Finally, we will report several experiments aimed at explicating the links between ostracism and pro-social or anti-social behavior.
THE HUBBLE CONSTANT : A SUMMARY OF THE HST PROGRAM FOR THE LUMINOSITY CALIBRATION OF TYPE Ia SUPERNOVAE BY MEANS OF CEPHEIDS

This is the summary paper of our 15 year program using the Hubble Space Telescope (HST) to determine the Hubble constant using Type Ia supernovae, calibrated with Cepheid variables in nearby galaxies that hosted them. In four previous papers new metallicity-dependent P -L relations of the Cepheids in LMC
Development and Validation of the Brief Music in Mood Regulation Scale (B-MMR)

All material supplied via JYX is protected by copyright and other intellectual property rights, and duplication or sale of all or part of any of the repository collections is not permitted, except that material may be duplicated by you for your research use or educational purposes in electronic or print form. You must obtain permission for any other use. Electronic or print copies may not be offered, whether for sale or otherwise to anyone who is not an authorised user. Development and Validation of the Brief Music in Mood Regulation Scale (B-MMR) Saarikallio, Suvi
Cognition in Context - The effect of information and communication support on task performance of distributed professionals

Mobile collaboration is emerging. Developments in technological and business areas provide opportunities for innovative applications and new ways of working. Mobile applications have possibilities to provide context information and to enrich the communication between distributed professionals. Such applications benefit from construct-driven assessments in earlier phases of design. Cognition in Context designs and evaluates two mobile applications for home care and railway. User experiments are conducted to test their added value on task performance and the perceptions of the experts on its usefulness and applicability. The results reveal that both cognitive and affective aspects are relevant for designing the applications, especially proficient decision-making and empowerment. Moreover, this study shows early identification of performance expectancies and suggestions to improve its applicability in practice: the relevance of cost-effective methods in IT innovation research.
Experimental characterization of the core plasma flow at the ASDEX Upgrade tokamak

In order to understand transport process in fusion plasmas a precise knowledge of the plasma flow topology is required. To measure all flow components in detail, a new spectroscopic system was installed at the fusion experiment ASDEX Upgrade. As main result of this Ph.D. thesis it is shown that the core poloidal rotation significantly deviates from theoretical predictions.
DIFFERENTIATION OF HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS INTO INSULIN PRODUCING BETA CELLS FOR DIABETIC THERAPY.

1. Department of Genetics and Molecular Medicine. 2. Department of Obstetrics and Gynecology. 3. Department of Microbiology, Department of Pathology,Department of Biochemistry, Kamineni Hospitals, L.B. Nagar, Hyderabad. 4. Indian Immunologicals Limited, Gachibowli, Hyderabad. Manuscript Info Abstract . Manuscript History
Towards a consistent cosmology with supersymmetry and leptogenesis

We study the cosmological interplay between supersymmetry, thermal leptogenesis as the origin of matter and the Peccei-Quinn mechanism as solution to the strong CP problem. We investigate to what extent the decay of the lightest ordinary supersymmetric particle, which usually spoils primordial nucleosynthesis in scenarios with gravitino dark matter, can become harmless due to entropy production. We study this possibility for a general neutralino. We find that strong constraints on the entropy-producing particle exclude generic thermal relics as source of sufficient entropy. However, the Peccei-Quinn supermultiplet (axion, saxion, axino) may not only be part of the particle spectrum, but the saxion can also produce a suitable amount of entropy. Exploiting cosmological perturbation theory we show that the corresponding expansion history can be falsified by future observations of the gravitational wave background from inflation, if polarisation measurements of the cosmic microwave background are combined with very sensitive gravitational wave probes. Since the same problem can also be solved by a small breaking of R-parity, we investigate the impact of broken R-parity on the Peccei-Quinn supermultiplet. We find that naturally expected spectra become allowed. Bounds from late particle decays become weaker than those from non-thermal axion production. Thus the strong CP problem serves as an additional motivation for broken R-parity. We show that, if the gravitino problem is solved by a light axino, “dark radiation” emerges naturally after primordial nucleosynthesis but before photon decoupling. Current observations of the cosmic microwave background could confirm an increase in the radiation energy density. The other way around, this solution to the gravitino problem implies that thermal leptogenesis might predict such an increase. The Large Hadron Collider could endorse this opportunity. In the same parameter range, axion and axino can naturally form the observed dark matter.
Macroscopic Magnetic Coupling Effect: The Physical Origination of a High-Temperature Superconducting Flux Pump

© 2018 American Physical Society. We have uncovered at the macroscopic scale a magnetic coupling phenomenon in a superconducting YBa2Cu3O7-δ (YBCO) film, which physically explains the mechanism of the high-Temperature superconducting flux pump. The coupling occurs between the applied magnetic poles and clusters of vortices induced in the YBCO film, with each cluster containing millions of vortices. The coupling energy is verified to originate from the inhomogeneous field of the magnetic poles, which reshapes the vortex distribution, aggregates millions of vortices into a single cluster, and accordingly moves with the poles. A contrast study is designed to verify that, to provide the effective coupling energy, the applied wavelength must be short while the field amplitude must be strong, i.e., local-field inhomogeneity is the crucial factor. This finding broadens our understanding of the collective vortex behavior in an applied magnetic field with strong local inhomogeneity. Moreover, this phenomenon largely increases the controlled vortex flow rate by several orders of magnitude compared with existing methods, providing motivation for and physical support to a new branch of wireless superconducting dc power sources, i.e., the high-Temperature superconducting flux pump.
Global Imbalances : Time for Action

Nicholas R. Lardy has been a senior fellow at the Peterson Institute since 2003. He was a senior fellow in the Foreign Policy Studies Program at the Brookings Institution from 1995 to 2003. He was the director of the Henry M. Jackson School of International Studies at the University of Washington from 1991 to 1995. From 1997 through the spring of 2000, he was the Frederick Frank Adjunct Professor of International Trade and Finance at the Yale University School of Management. His most recent publications are China’s Rise: Challenges and Opportunities (2008) and Debating China’s Exchange Rate Policy (2008). Other publications include China: The Balance Sheet—What the World Needs to Know Now about the Emerging Superpower (2006), Prospects for a US-Taiwan Free Trade Agreement (2004), Integrating China into the Global Economy (2002), China’s Unfinished Economic Revolution (1998), China in the World Economy (1994), Foreign Trade and Economic Reform in China, 1978–1990 (1992), and Agriculture in China’s Modern Economic Development (1983). He is a member of the Council on Foreign Relations and of the editorial boards of the China Quarterly, Journal of Asian Business, China Review, and China Economic Review.
Équations différentielles caractéristiques de la sphère

© Gauthier-Villars (Éditions scientifiques et médicales Elsevier), 1979, tous droits réservés. L’accès aux archives de la revue « Annales scientifiques de l’É. N.S. » (http://www. elsevier.com/locate/ansens) implique l’accord avec les conditions générales d’utilisation (http://www.numdam.org/conditions). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.
Distributed Optimization Over Time-Varying Directed Graphs

We consider distributed optimization by a collection of nodes, each having access to its own convex function, whose collective goal is to minimize the sum of the functions. The communications between nodes are described by a time-varying sequence of directed graphs, which is uniformly strongly connected. For such communications, assuming that every node knows its out-degree, we develop a broadcast-based algorithm, termed the subgradient-push, which steers every node to an optimal value under a standard assumption of subgradient boundedness. The subgradient-push requires no knowledge of either the number of agents or the graph sequence to implement. Our analysis shows that the subgradient-push algorithm converges at a rate of O(\ln t √t). The proportionality constant in the convergence rate depends on the initial values at the nodes, the subgradient norms and, more interestingly, on both the speed of the network information diffusion and the imbalances of influence among the nodes.
The effect of antagonizing rgD-binding integrin activity in papillary thyroid cancer cell lines

: Patients with papillary thyroid cancer (PTC) generally have good prognosis, but inoperable and radioactive iodine–refractory PTC still poses significant clinical challenges due to lack of effective treatment and higher mortality rates. Given the important role of integrins in multiple steps of tumor development, integrin-targeting therapy could be an effective strategy for PTC therapy. In this study
Compact ultrafast frequency combs

Optical frequency combs provide a direct and phase-coherent link between the optical spectral region of the electromagnetic spectrum (i.e., hundreds of THz frequencies) and the radio-frequency domain (MHz-GHz frequencies). As a result, they constitute a unique and powerful tool for various applications such as broadband high-resolution molecular spectroscopy, optical metrology, astrophysics, optical clocks, fundamental science and many other fields of research. Frequency combs with a high repetition rate are of particular interest for applications that can benefit from a high power per comb mode and a lower spectral density of comb modes, which makes the selection and filtering of a single optical line easier, and increases the signal-to-noise ratio in sensitive measurements. Modelocked diode-pumped solid-state lasers (DPSSLs) are a perfect solution to generate high-power high repetition rate frequency combs. In this thesis, a 1-GHz comb based on a 1-μm DPSSL has been developed, with multiwatt output power and sub-100 fs pulse durations. This laser is an important step towards the development of compact cost-efficient frequency combs since it is pumped by a low-cost highly multimode pump laser diode. The optical spectrum of the laser has been fully stabilized by phase-locking both the repetition rate frequency to a radio-frequency (RF) reference signal by means of a piezoelectrical transducer controlling the cavity length of the laser, and the carrierenvelope offset (CEO) frequency using the traditional method of feedback to the pump current. This was achieved using a home-made high-bandwidth current vii
Trace scaling automorphisms of $\mathcal{W}\otimes\mathbb{K}$

We classify trace scaling automorphisms of $\mathcal{W}\otimes\mathbb{K}$ up to outer conjugacy, where $\mathcal{W}$ is a certain simple separable nuclear stably projectionless C$^*$-algebra having trivial $K$-groups. Also, we show that all automorphisms of $\mathcal{W}$ with the Rohlin property are outer conjugate to each other. Moreover, we show that the central sequence C$^*$-algebra $F(\mathcal{W})$ of $\mathcal{W}$ is infinite.