Miracle-dz/UniFAR-FTUs huggingface dataset:
Wide Field Planetary Camera 2 Imaging of the Globular Cluster System of the S0 Galaxy NGC 3115

Using the Wide Field Planetary Camera 2 on board the Hubble Space Telescope we have identified 144 globular cluster candidates in the inner region of the S0 galaxy NGC 3115. The color distribution of the globular clusters is bimodal, with a blue peak at V-I = 0.96 mag and a red peak at V-I = 1.17 mag. There are roughly equal number of blue and red clusters. The mean [Fe/H] of the blue population is -1.36 dex, while the red population has a mean [Fe/H] of -0.37 dex. Following Ashman & Zepf, we interpret the bimodality as evidence of multiple epochs of cluster formation in the metal enrichment history of the galaxy. Assuming that the blue peak corresponds to a primordial, 15 Gyr old, metal-poor population of globular clusters, we derive an age of 11 ± 3 Gyr for the younger, red clusters. We also find that the age and metallicities of the globular clusters are consistent with the red giant stars in the field, suggesting that the two systems formed coevally. The spatial distribution of both the red and the blue clusters are flattened with major and minor axes roughly colinear with the galaxy light profile. While the red clusters follow the thick disk component of the galaxy, the blue cluster distribution is less flattened and mimics the bulge/halo light distribution. We find a local specific frequency of 1.3 ± 0.1 in the central region of the galaxy, which is lower than the global value of 2.3 ± 0.5 reported in the literature, implying that the specific frequency increases with galactocentric distance. We have also observed the globular cluster luminosity function 2 mag deeper than the turnover luminosity and derived a distance modulus of m-M = 29.8 ± 0.3 mag to NGC 3115. The average half-light radii of the clusters is ≈2 pc, and the red clusters are ≈20% smaller than the blue ones.
Isolation of Potential Probiotic Bacillus spp. from the Intestine of Nile Tilapia to Construct Recombinant Probiotic Expressing CC Chemokine and Its Effectiveness on Innate Immune Responses in Nile Tilapia

Simple Summary The application of recombinant technology provides the possibility for the establishment of ideal probiotics as an alternative novel therapeutic approach by integrating promising heterologous proteins into the chromosome of conventional probiotics. In our previous study, we found that Nile tilapia CC chemokine genes had multiple roles in homeostatic functions in both immune and non-immune tissues. Moreover, they are crucially involved in the early immune responses to pathogens. Therefore, in this study, we isolated and characterized the potential probiotic Bacillus subtilis from the intestine of Nile tilapia to use as a live vehicle for delivering CC chemokine proteins directly to the intestine. Our results suggest that dietary supplementation with either wild-type or recombinant probiotics could enhance the immune responses of Nile tilapia, with stronger stimulation observed in the recombinant probiotics-supplemented group. It could be concluded that applying genetically engineered probiotics for developing novel strategies would provide greater health benefits through a combination efficacy of potential probiotics and desirable heterologous proteins. Abstract This study aimed to investigate the potential probiotic Bacillus spp. from the intestine of Nile tilapia in order to construct a recombinant probiotic for the enhancement of the Nile tilapia immune response. One hundred bacterial isolates from the intestine of Nile tilapia were characterized for species identification using the 16s ribosomal RNA (rRNA). Only Bacillus isolates with exhibited antagonistic activity were investigated for their biological functions, which included protease-producing capacity, bile salts and pH tolerance, antibiotic susceptibility, and pathogenicity tests. According to the best results, Bacillus isolate B29, as closely related to B. subtilis, was selected to construct a recombinant probiotic for the delivery of CC chemokine protein (pBESOn-CC). The existence of recombinant probiotics was confirmed by Western blotting before the feeding trial. In addition, the CC chemokine mRNA level was quantified in the intestine of fish fed probiotics after 30 days of feeding. Total immunoglobulin, lysozyme activity, alternative complement 50 activity (ACH50), and phagocytic activity of fish fed either wild-type or recombinant probiotics were significantly increased, indicating that probiotics could stimulate the Nile tilapia immune system through different processes. Interestingly, the dietary supplementation of recombinant probiotics has a stronger immune response enhancement than the wild-type strain.
Observations of the Hubble Deep Field with the Infrared Space Observatory V. Spectral energy distributions starburst models and star formation history

We have modelled the spectral energy distributions of the 13 Hubble Deep Field (HDF) galaxies reliably detected by the Infrared Space Observatoiy (ISO). For two galaxies the emission detected by ISO is consistent with being starlight or the infrared 'cirrus' in the galaxies. For the remaining 11 galaxies there is a clear mid-infrared excess, which we interpret as emission from dust associated with a strong starburst. 10 of these galaxies are spirals or interacting pairs, while the remaining one is an elliptical with a prominent nucleus and broad emission lines. We give a new discussion of how the star formation rate can be deduced from the far-infrared luminosity, and derive star formation rates for these galaxies of 8-1000o M? yr-1, where o takes account of the uncertainty in the initial mass function. The HDF galaxies detected by ISO are clearly forming stars at a prodigious rate compared with nearby normal galaxies. We discuss the implications of our detections for the history of star and heavy element formation in the Universe. Although uncertainties in the calibration, reliability of source detection, associations and starburst models remain, it is clear that dust plays an important role in star formation out to redshift 1 at least.
Initial Condition Sensitivity and Error Growth in Forecasts of the 25 January 2000 East Coast Snowstorm

Abstract Short- and medium-range (24–96-h) forecasts of the January 2000 U.S. east coast cyclone and associated snowstorm are examined using the U.S. Navy global forecast model and adjoint system. Attention is given to errors on the synoptic scale, including forecast position and central pressure of the cyclone at the verification time of 1200 UTC 25 January 2000. There is a substantial loss of predictive skill in the 72- and 96-h forecasts, while the 24- and 48-h forecasts capture the synoptic-scale features of the cyclone development with moderate errors. Sensitivity information from the adjoint model suggests that the initial conditions for the 72-h forecast starting at 1200 UTC 22 January 2000 contained relatively small, but critical, errors in upper-air wind and temperature over a large upstream area, including part of the eastern Pacific and “well observed” areas of western and central North America. The rapid growth of these initial errors in a highly unstable flow regime (large singular-vector gro.
The effect of ageing on confrontation naming in healthy older adults: a three-level meta-analysis

ABSTRACT Older adults frequently report trouble retrieving words, which is often tested by confrontation naming tasks. However, with inconsistencies among the relevant literature, this ageing effect requires an updated meta-analysis (with the only meta-analysis conducted in 1997), especially when no meta-analysis has been conducted on how such an effect may be modulated by the important factor of education. By synthesizing 41 primary studies, the present meta-analysis revealed a significant ageing effect on confrontation naming (indexed by accuracy), which was modulated by participant age and education. First, a significant ageing effect only occurred in participants aged 70 and above (compared with participants below 60). Second, participants with low- and middle-level education exhibited significantly larger ageing effects than those with high-level education. Third, for the age-and-education interaction, an ageing effect occurred as early as 60 in participants in the low-and-middle education level, while this critical age for participants with high-level education is 70.
Stability of stationary interfaces with contact angle in a generalized mean curvature flow

The dynamics of a moving hypersurface in a domain D N is studied. It is assumed that the hypersurface moves depending on its curvature, normal vector and position with the boundary that intersects D with a constant contact angle. A stability criterion about a stationary hypersurface is established in the form of an eigenvalue problem, which includes geometrical information of D and the stationary hypersurface. 1. Introduction. In this paper, we study the dynamics of an oriented hy- persurface Γ(t )i n N that evolves in time t 0 continuously. Here, we call such an oriented hypersurface an interface. We assume that the motion of Γ(t) depends on its curvature, normal vector and position x Γ(t). Then we are led to the equation V(x )= F ( ( x), (x), x), x Γ(t), t 0, (1.1) where (x )a nd ( x ) are the mean curvature and the outward unit normal vector of Γ(t )a t x Γ ( t ), respectively, and V(x) is the normal velocity in the out- ward direction at x Γ(t). We assume that the function F depends smoothly on ( , , x) 1 N 1 N and satisfies
Iron sensing in plants

The ease of accepting or donating electrons is the raison d’être for the pivotal role iron (Fe) plays in a multitude of vital processes. In the presence of oxygen, however, this very property promotes the formation of immobile Fe(III) oxyhydroxides in the soil, which limits the concentration of Fe that is available for uptake by plant roots to levels well below the plant’s demand. To adequately respond to a shortage (or, in the absence of oxygen, a possible surplus) in Fe supply, plants have to perceive and decode information on both external Fe levels and the internal Fe status. As a further challenge, such cues have to be translated into appropriate responses to satisfy (but not overload) the demand of sink (i.e., non-root) tissues. While this seems to be a straightforward task for evolution, the multitude of possible inputs into the Fe signaling circuitry suggests diversified sensing mechanisms that concertedly contribute to govern whole plant and cellular Fe homeostasis. Here, we review recent progress in elucidating early events in Fe sensing and signaling that steer downstream adaptive responses. The emerging picture suggests that Fe sensing is not a central event but occurs in distinct locations linked to distinct biotic and abiotic signaling networks that together tune Fe levels, Fe uptake, root growth, and immunity in an interwoven manner to orchestrate and prioritize multiple physiological readouts.
Optical and acoustic investigations of the dynamics of laser-produced cavitation bubbles near a solid boundary

The dynamics of laser-produced cavitation bubbles near a solid boundary and its dependence on the distance between bubble and wall are investigated experimentally. It is shown by means of high-speed photography with up to 1 million frames/s that jet and counterjet formation and the development of a ring vortex resulting from the jet flow are general features of the bubble dynamics near solid boundaries. The fluid velocity field in the vicinity of the cavitation bubble is determined with time-resolved particle image velocimetry. A comparison of path lines deduced from successive measurements shows good agreement with the results of numerical calculations by Kucera & Blake (1988). The pressure amplitude, the profile and the energy of the acoustic transients emitted during spherical bubble collapse and the collapse near a rigid boundary are measured with a hydrophone and an optical detection technique. Sound emission is the main damping mechanism in spherical bubble collapse, whereas it plays a minor part in the damping of aspherical collapse. The duration of the acoustic transients is 20-30 ns. The highest pressure amplitudes at the solid boundary have been found for bubbles attached to the boundary. The pressure inside the bubble and at the boundary reaches about 2.5 kbar when the maximum bubble radius is 3.5 mm. The results are discussed with respect to the mechanism of cavitation erosion.
Association of Cardiovascular Mortality with Concurrent Coronary Artery Calcification and Physical Activity: A Cohort Study

Background: Increased coronary artery calcification (CAC) has been reported in individuals with high levels of physical activity (PA). However, the association between increased CAC in a physically active population and cardiovascular mortality has not yet been well-established. This study aimed to investigate the association between PA levels and the presence or absence of CAC and cardiovascular mortality. Methods: A cohort study was conducted from 1 January 2011 to 30 December 2019. Mortality data were updated until 30 December 2020. The study population comprised 56,469 individuals who had completed the International Physical Activity Short Form Questionnaire and had undergone CAC score evaluation using a CT scan. We divided the participants into four groups: physically inactive individuals without CAC, physically inactive individuals with CAC, moderately active and health-enhancing physically active (HEPA) individuals without CAC, and moderately active and HEPA individuals with CAC. The primary outcome was cardiovascular mortality. The Cox proportional hazard model with confounding factor adjustment was conducted. Inverse probability of treatment weighting-based marginal-structural modelling was conducted. Results: The median follow-up duration was 6.60 years. The mean (SD) age of the study participants was 41.67 (±10.91) years, with 76.78% (n = 43,359) men. Compared with individuals without CAC, individuals with CAC demonstrated higher cardiovascular disease mortality regardless of PA level (Inactive and CAC > 0, HR 2.81, 95% CI: 1.76–19.19; moderately active and HEPA HR 3.27, 95% CI: 1.14–9.38). Conclusions: The presence of CAC might be associated with cardiovascular mortality regardless of PA level.
Estimation of Monthly Rainfall over Oceans from Truncated Rain-Rate Samples: Application to SSM/I Data

Abstract A physical–statistical monthly rainfall retrieval algorithm has been developed using multichannel brightness temperatures from the Special Sensor Microwave/Imager (SSM/I). Since an emission-based retrieval algorithm gives the most physically direct estimation of rainfall over oceans, instantaneous rain rates are retrieved using brightness temperature–rain rate (T–R) relationships derived from a radiative transfer model. The retrieved rain rates, however, are only reliable and useful over a portion of a whole dynamic range of rain rate due to limitations of the emission-based algorithm. When monthly rainfall in a 5° × 5° box is estimated, the instantaneous rain-rate samples are actually truncated. The method used in this study assumes that monthly rainfall intensity in a 5° × 5° box has a mixed lognormal distribution. Thus, the contribution of the rain rates outside of the dynamic range can be estimated by extrapolation. Coefficients of the mixed lognormal distribution are determined by fitting th.
What Leads to the Changes of Volatility Spillover Effect Between Chinese and American Soybean Futures Markets?

ABSTRACT This paper examines the volatility spillover between the soybean futures contracts traded in the US Chicago Board of Trade (CBOT) and China Dalian Commodity Exchange (DCE) through a normalized Copula – GARCH(1,1) - t model with structural changes. The structural change points are identified through a combination of Bayesian diagnosis with Z-test. The study finds that the volatility spillover exists between the DCE and CBOT soybean futures and weakens through time. We further identify seven structural change points in the volatility spillover relationship, suggesting it is going through significant structural changes. The changes are related to major social-political events including the trade conflict between China and the US, the COVID-19 pandemic and the Russia-Ukraine war.
Prediction of gas tungsten arc welding properties in mixtures of argon and hydrogen

A theory of gas tungsten arc welding (GTAW) arcs that treats the tungsten electrode, the arc, and the workpiece as a unified system has been applied to make predictions in two dimensions of the temperature distributions in the arc, the tungsten cathode, and the workpiece, for any given arc current and gas mixture. Predictions of arc temperatures, radii, and voltages are compared for argon and mixtures of argon and hydrogen. It is found that arcs in gas mixtures containing hydrogen are more constricted and have a higher maximum temperature and arc voltage than arcs in pure argon. The addition of hydrogen also significantly increases the volume of molten material in the weld pool due to the higher thermal conductivity of argon-hydrogen mixtures at temperatures at which molecules of hydrogen dissociate. Predictions are also compared for workpieces of steel and aluminum. The volume of molten material is very much less for aluminum, despite its lower melting point, because of the higher thermal conductivity of aluminum. Predicted arc voltages as a function of current for a mixture of 10% hydrogen in argon are in good agreement with experimental results.
Framing smart working in the Covid-19 era: a data driven approach

In the last years, smart working has been introduced as an agile and dynamic way of working which provides high levels of performance, productivity, and job satisfaction in a “triple-win” configuration for customers, employees, and organizations. Although the advantages and disadvantages related to these new working practices have been recognized by the literature, how these new work practices, widely adopted during the Covid-19 pandemic, have been generally perceived on a massive scale is still unclear. Based on these considerations, this work aims to carry out a big data analysis in order to frame the collective perception about smart working. A large-scale text analytics study has been conducted on Twitter from January to June 2021. The data-driven approach identified the most frequently used macro-concepts about smart working by Twitter’s users: five perceived in a positive way (smartness, work-life balance, flexible approach, productivity, innovative working environment) and five perceived negatively (tech paralysis, technostress, technology hiccups, demotivation, social isolation). In this sense, the study offers several insights by generating useful implications for researchers and professionals both in the organizational design and psychological and Human Resources Management field.
Mycobacterium vaccae NCTC 11659, a Soil-Derived Bacterium with Stress Resilience Properties, Modulates the Proinflammatory Effects of LPS in Macrophages

Inflammatory conditions, including allergic asthma and conditions in which chronic low-grade inflammation is a risk factor, such as stress-related psychiatric disorders, are prevalent and are a significant cause of disability worldwide. Novel approaches for the prevention and treatment of these disorders are needed. One approach is the use of immunoregulatory microorganisms, such as Mycobacterium vaccae NCTC 11659, which have anti-inflammatory, immunoregulatory, and stress-resilience properties. However, little is known about how M. vaccae NCTC 11659 affects specific immune cell targets, including monocytes, which can traffic to peripheral organs and the central nervous system and differentiate into monocyte-derived macrophages that, in turn, can drive inflammation and neuroinflammation. In this study, we investigated the effects of M. vaccae NCTC 11659 and subsequent lipopolysaccharide (LPS) challenge on gene expression in human monocyte-derived macrophages. THP-1 monocytes were differentiated into macrophages, exposed to M. vaccae NCTC 11659 (0, 10, 30, 100, 300 µg/mL), then, 24 h later, challenged with LPS (0, 0.5, 2.5, 250 ng/mL), and assessed for gene expression 24 h following challenge with LPS. Exposure to M. vaccae NCTC 11659 prior to challenge with higher concentrations of LPS (250 ng/mL) polarized human monocyte-derived macrophages with decreased IL12A, IL12B, and IL23A expression relative to IL10 and TGFB1 mRNA expression. These data identify human monocyte-derived macrophages as a direct target of M. vaccae NCTC 11659 and support the development of M. vaccae NCTC 11659 as a potential intervention to prevent stress-induced inflammation and neuroinflammation implicated in the etiology and pathophysiology of inflammatory conditions and stress-related psychiatric disorders.
Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs

Consumers and manufacturers are exposed to nanosized zinc oxide (nZnO) and silver particles (nAg) via airways, but their biological effects are still not fully elucidated. To understand the immune effects, we exposed mice to 2, 10, or 50 μg of nZnO or nAg by oropharyngeal aspiration and analyzed the global gene expression profiles and immunopathological changes in the lungs after 1, 7, or 28 days. Our results show that the kinetics of responses varied in the lungs. Exposure to nZnO resulted in the highest accumulation of F4/80- and CD3-positive cells, and the largest number of differentially expressed genes (DEGs) were identified after day 1, while exposure to nAg caused peak responses at day 7. Additionally, nZnO mainly activated the innate immune responses leading to acute inflammation, whereas the nAg activated both innate and adaptive immune pathways, with long-lasting effects. This kinetic-profiling study provides an important data source to understand the cellular and molecular processes underlying nZnO- and nAg-induced transcriptomic changes, which lead to the characterization of the corresponding biological and toxicological effects of nZnO and nAg in the lungs. These findings could improve science-based hazard and risk assessment and the development of safe applications of engineered nanomaterials (ENMs), e.g., in biomedical applications.