Miracle-dz/UniFAR-FTUs huggingface dataset:
Finite-element analysis of a switched reluctance motor under static eccentricity fault

This paper describes a two-dimensional finite-element analysis of an 8/6 switched reluctance motor with static eccentricity. It describes the influence of the eccentricity on the static characteristics of the motor and shows how to obtain flux lines, flux density distribution, and the flux-linkage/rotor angular position characteristic of the motor in both healthy and faulty conditions, as well as the static torque profiles of phases for different degrees of eccentricity. It shows that, at low current, the effect of the eccentricity is considerable compared to that at the rated current. Fourier analysis of the torque profile is used to study the variations of static torque harmonic contents.
Long term results of total hip arthroplasty with cemented and cementless tapered femoral component

Background: Excellent midterm results for total hip arthroplasties (THA) with cementless, tapered porous Taperloc® femoral stems have been reported. Reports regarding such cemented stems, however, are lacking. Objectives: To evaluate the long-term outcomes of both cemented and cementless THAs with the Taperloc femoral component. Methods: The medical records of 71 patients (76 hips), operated on between January 1991 and December 2003, who had a minimum follow-up of 10 years were available for analysis. Functional analysis was performed with the Harris hip score (HHS) questionnaire and the numerical analogue scale (NAS). Radiographic analysis was performed for subsidence, radiolucent lines and osteolysis. Results: The cohort was comprised of 47 female and 24 male patients, with a mean age of 59.7 ± 12.4 years. The mean follow-up was 17.8 ± 4.4 years. 52.6% of THAs analyzed were cementless and 47.4% were cemented. Post-operative radiographs were available for 57 surgeries. Subsidence, hypertrophic ossification, radiolucent lines and osteolysis were noted in 4 (7%), 2 (2.6%), 14 (18.4%) and 11 (14.5%) hips respectively. The average HHS score at a mean follow-up of 20.1 ± 3.9 years was 62.1 (±27.7) and the NAS score was 4.6 (±3.6). During the study period, five revision surgeries were performed due to stem-related problems, one of which was for aseptic loosening. Conclusions: Our long-term experience with the Taperloc stem, both cemented and cementless, demonstrates good outcomes, with low rates of failure. This makes this prosthesis an attractive option for THAs. Level of Evidence: IV
The role of nanoliposomal irinotecan plus fluorouracil/leucovorin in the continuum of care of patients with metastatic pancreatic ductal adenocarcinoma

The NAPOLI‐I trial showed better outcome of nanoliposomal irinotecan (nal‐IRI) plus 5‐fluorouracil/leucovorin (5‐FU/LV) compared to 5‐FU/LV in patients with advanced pancreatic ductal adenocarcinoma cancer (advPDAC) progressed to gemcitabine‐based therapy. This study aims to explore the real‐world efficacy and safety of 5‐FU/LV‐nal‐IRI.
EXPRESS: Decision-making and ageing: everyday life situations under risk and under ambiguity.

Cognitive modifications over ageing can affect decision making competence (DMC). As it is a core ability in autonomy preservation, our study aims to investigate its changes in old adults and to determine if they are linked to the deterioration of executive functions and working memory. For this purpose, 50 young adults and 50 old adults were assessed with executive, working memory and DMC tasks. The latter comprised the Iowa Gambling task (IGT) and a scenarii task based on daily life-inspired situations, under risk and under ambiguity conditions. Results revealed lower performances in old adults compared to young adults for updating, inhibition and working memory tasks. The IGT failed to distinguish the two groups of age, but the scenarii task did it, as young adults were more risk and ambiguity seekers than old adults. Moreover, updating and inhibition capacities appeared to influence DMC.
ROS signaling–induced mitochondrial Sgk1 expression regulates epithelial cell renewal

Significance Cell renewal is critical for tissue homeostasis and regeneration. Using a zebrafish model, we show that an increase in mitochondrial membrane potential and TCA cycle/OXPHOS are required and sufficient for the cell cycle reentry. The elevated mitochondrial activity leads to increased ATP synthesis and ROS production. Elevated mitochondrial ROS induces the mitochondrial expression of Sgk1. Sgk1 alters cell fate by modulating F1Fo-ATP synthase phosphorylation state and ATP synthesis. This signaling loop also mediates mitochondrial metabolism–dependent S phase entry of human breast cancer cells, suggesting that it is an evolutionarily conserved mechanism.
Biogeographic–tectonic calibration of 14 nodes in a butterfly timetree

The butterfly subtribe Coenonymphina (Nymphalidae: Satyrinae) comprises four main clades found, respectively, in (1) the Solomon Islands, (2) Australasia, (3) NW South America and (4) Laurasia, with a phylogeny: 1 (2 (3 + 4)). In assessing biogeographic evolution in the group we rejected the conversion of fossil‐calibrated clade ages to likely maximum clade ages by the imposition of arbitrary priors. Instead, we used biogeographic–tectonic calibration, with fossil‐calibrated ages accepted as minima. Previous studies have used this approach to date single nodes (phylogenetic–biogeographic breaks) in a group, but we extended the methodology to date multiple nodes. Within the Coenonymphina as a whole, 14 nodes coincide spatially with ten major tectonic events. In addition, the phylogenetic sequence of these nodes conforms to the chronological sequence of the tectonic events, consistent with a vicariance origin of the clades. Dating of the spatially coincident tectonic features provides a timescale for the vicariance events. The tectonic events are: pre‐drift intracontinental rifting between India and Australia (150 Ma); seafloor spreading at the margins of the growing Pacific plate, and between North and South America (140 Ma); magmatism flare‐up along the SW Pacific Whitsunday Volcanic Province–Median Batholith (130 Ma); a change from extension in the Clarence basin, eastern Australia, to uplift of the Great Dividing Range (114 Ma); Pamir Mountains uplift, foreland basin dynamics and high eustatic sea‐levels leading to marine transgression of the proto‐Paratethys Ocean eastward to Central Asia and Xinjiang (100 Ma); predrift rifting and seafloor spreading west of New Caledonia (100–50 Ma); sinistral strike‐slip displacement along the proto‐Alpine fault, New Zealand (100–80 Ma); thrust faulting in the Longmen Shan and foreland basin dynamics around the Sichuan Basin (85 Ma); pre‐drift rifting in the Coral Sea basin (85 Ma); and dextral displacement on the Alpine fault (20 Ma).
A Novel Model to Generate Heterogeneous and Realistic Time-Series Data for Post-Stroke Rehabilitation Assessment

The application of machine learning-based tele-rehabilitation faces the challenge of limited availability of data. To overcome this challenge, data augmentation techniques are commonly employed to generate synthetic data that reflect the configurations of real data. One such promising data augmentation technique is the Generative Adversarial Network (GAN). However, GANs have been found to suffer from mode collapse, a common issue where the generated data fails to capture all the relevant information from the original dataset. In this paper, we aim to address the problem of mode collapse in GAN-based data augmentation techniques for post-stroke assessment. We applied the GAN to generate synthetic data for two post-stroke rehabilitation datasets and observed that the original GAN suffered from mode collapse, as expected. To address this issue, we propose a Time Series Siamese GAN (TS-SGAN) that incorporates a Siamese network and an additional discriminator. Our analysis, using the longest common sub-sequence (LCSS), demonstrates that TS-SGAN generates data uniformly for all elements of two testing datasets, in contrast to the original GAN. To further evaluate the effectiveness of TS-SGAN, we encode the generated dataset into images using Gramian Angular Field and classify them using ResNet-18. Our results show that TS-SGAN achieves a significant accuracy increase of classification accuracy (35.2%-42.07%) for both selected datasets. This represents a substantial improvement over the original GAN.
A Contemporary Study in Gauge Theory and Mathematical Physics: Holomorphic Anomaly in Gauge Theory on ALE Space & Freudenthal Gauge Theory

This thesis covers two distinct parts: Holomorphic Anomaly in Gauge Theory on ALE Space and Freudenthal Gauge Theory.In part I, I presented a concise review of the Seiberg-Witten curve, Nekrasov's background, geometric engineering and the holomorphic anomaly equation followed by my published work: Holomorphic Anomaly in Gauge Theory on ALE Space, where an deformed N = 2 SU(2) gauge theory on A1 space and its five dimension lift is studied.We find that the partition functions can be reproduced via special geometry and the holomorphic anomaly equation. Schwinger type integral expressions for the boundary conditions at the monopole/dyon point in moduli space are inferred. The interpretation of the five dimensional partition function as the partition function of a refined topological string on A1×(local P1 × P1) is suggested.In part II, I give a comprehensive review of the Freudenthal Triple System, including Freudenthal's orginal construction from Jordan Triple Systems and its relation to Lie algebra, Yang-Baxter equation, and 4d N = 2 BPS black holes, where the novel Freudenthal-dualwas discovered. I also present my published work on the Freudenthal Gauge Theory, where we construct the most generic gauge theory admitting F-dual, and prove a no-go theorem that forbids coupling of a F-dual invariant gauge theory to supersymmetry.
White matter abnormalities are associated with the declined ability of reasoning and problem‐solving in major depressive disorder

Executive function in people with depression is linked to the integrity of white matter fibers in the brain. We hypothesized that the maze tests in neuropsychological tests assessed reasoning and problem‐solving abilities dependent on the integrity of brain white matter fibers, and assessed this relationship using diffusion tensor imaging (DTI) in depressed patients and healthy controls.
The Effects of Virtual Reality Glasses on Vital Signs and Anxiety in Patients Undergoing Colonoscopy

Colonoscopy is a painful procedure that causes anxiety and changes in vital signs. Pain and anxiety may cause patients to avoid colonoscopy, which is a preventive and curative healthcare service. The aim of this study was to examine the effects of virtual reality glasses on the vital signs (blood pressure, pulse, respiration, oxygen saturation, and pain) and anxiety in patients undergoing colonoscopy. The population of the study consisted of 82 patients who underwent colonoscopy without sedation between January 2, 2020, and September 28, 2020. Post-power analysis was performed with 44 patients who agreed to participate in the study, met the inclusion criteria, and were followed up for pre- and post-tests. The experimental group participants (n = 22) watched a 360° virtual reality video through virtual reality glasses whereas the control group participants (n = 22) underwent a standard procedure. Data were collected using a demographic characteristics questionnaire, the Visual Analog Scale-Anxiety, Visual Analog Scale-Pain, Satisfaction Evaluation Form, and monitoring of vital signs. The experimental group participants had significantly lower levels of pain, anxiety, systolic blood pressure, and respiratory rate and significantly higher peripheral oxygen saturation during colonoscopy than the control group participants. The majority of the experimental group participants were satisfied with the application. Virtual reality glasses have a positive effect on vital signs and anxiety during colonoscopy.
Two‐pore channel 1 and Ca2+ release‐activated Ca2+ channels contribute to the acrosomal pH‐dependent intracellular Ca2+ increase in mouse sperm

The acrosome is a lysosome‐related vesicular organelle located in the sperm head. The acrosomal reaction (AR) is an exocytic process mediated by Ca2+ and essential for mammalian fertilization. Recent findings support the importance of acrosomal alkalinization for the AR. Mibefradil (Mib) and NNC 55‐0396 (NNC) are two amphipathic weak bases that block the sperm‐specific Ca2+ channel (CatSper) and induce acrosomal pH (pHa) increase by accumulating in the acrosomal lumen of mammalian sperm. This accumulation and pHa elevation increase the intracellular Ca2+ concentration ([Ca2+]i) and trigger the AR by unknown mechanisms of Ca2+ transport. Here, we investigated the pathways associated with the pHa increase‐induced Ca2+ signals using mouse sperm as a model. To address these questions, we used single‐cell Ca2+ imaging, the lysosomotropic agent Gly‐Phe‐β‐naphthylamide (GPN) and pharmacological tools. Our findings show that Mib and NNC increase pHa and release acrosomal Ca2+ without compromising acrosomal membrane integrity. Our GPN results indicate that the osmotic component does not significantly contribute to acrosomal Ca2+ release caused by pHa rise. Inhibition of two‐pore channel 1 (TPC1) channels reduced the [Ca2+]i increase stimulated by acrosomal alkalinization. In addition, blockage of Ca2+ release‐activated Ca2+ (CRAC) channels diminished Ca2+ uptake triggered by pHa alkalinization. Finally, our findings contribute to understanding how pHa controls acrosomal Ca2+ efflux and extracellular Ca2+ entry during AR in mouse sperm.
Application of G-CSF in high-leukocyte acute myeloid leukemia is a poor prognostic factor

ABSTRACT Objective To analyze the effect of granulocyte colony-stimulating factor (G-CSF) on outcomes in patients with acute myeloid leukemia (AML). Methods A total of 526 patients with AML in the Haematology Department were enrolled. They were divided into a G-CSF treatment group and a no G-CSF group according to whether G-CSF was administered in the induction chemotherapy period, with 355 cases in the G-CSF group and 171 cases in the no G-CSF group. Cox regression analysis and Kaplan-Meier curve analysis were used to analyze the effect of G-CSF on the first complete remission (CR1) phase and overall survival (OS). In addition, further analysis was performed based on an initial white blood cell count of 50 * 10^9/L. Results The application of G-CSF significantly shortened the CR1 phase and OS in patients with high leukocytes. Conclusions G/GM-CSF should be used with caution in patients with AML, especially those with high leukocytes.
Risk factors for deep neck infection in patients with sore throat and neck pain

ABSTRACT BACKGROUND: Deep neck infection (DNI) is a potentially life-threatening disease because infections spread quickly, causing serious complications. Therefore, more attention is needed than other neck infections, but there are many difficulties due to isolation guidelines in the period of coronavirus disease 2019 pandemic. We investigated the early predictability of DNI through patient symptoms at the first emergency department encounter. METHODS: This was a retrospective study of patients with suspected soft-tissue neck infections from January 2016 to February 2021. Symptoms were retrospectively analyzed in fever, foreign body sensation, chest discomfort/pain, submandibular pain, odynophagia, dysphagia, voice change, and severe pain. Furthermore, baseline characteristic data, laboratory findings, and pre-vertebral soft-tissue (PVST) thickness were evaluated. DNI and other neck infections were diagnosed through computed tomography. Logistic regression analysis was conducted to determine the independent factors for predicting DNI. RESULTS: In the 793 patients included in the study, 267 (33.7%) were diagnosed with DNI, and 526 (66.3%) were diagnosed with other soft-tissue neck infections. In the comparison between the two groups, C-reactive protein (CRP), sodium, PT (INR), foreign body sensation, chest discomfort/pain, submandibular pain, odynophagia, dysphagia, severe pain, and PVST thickness showed statistically significant differences. Independent factors for predicting DNI were severe pain (odds ratio: 6.336 [3.635–11.045], p<0.001), foreign body sensation (odds ratio: 7.384 [2.776–19.642], p<0.001), submandibular pain (odds ratio: 4.447 [2.852–6.932], p<0.001), and dysphagia (odds ratio: 52.118 [8.662–313.588], p<0.001) among symptoms and CRP (odds ratio: 1.034 [1.004–1.065], p=0.026) and PT (INR) (odds ratio: 29.660 [3.363–261.598], p=0.002) in laboratory tests. PVST thickness at C2 (odds ratio: 1.953 [1.609–2.370], p<0.001) and C6 level (odds ratio: 1.179 [1.054–1.319], p=0.004) was also shown as an independent variable for prediction. CONCLUSION: Among patients with sore throat or neck pain, patients with dysphagia, foreign body sensation, severe pain, and submandibular pain are more likely to have DN. DNI can cause serious complications; therefore, patients with the above symptoms should be closely observed due to the potential for significant complications.
Brief paper - r-consensus control for discrete-time high-order multi-agent systems

This study considers a consensus problem of discrete-time high-order multi-agent systems with digraph. A concept r-consensus for discrete-time multi-agent systems is introduced, and consensus protocols are proposed for solving such problems. A sufficient and necessary condition for r-consensus is obtained using matrix theory. As a special case, criteria of r-consensus for third-order systems are given, in which the exact relationship of feedback parameters is established. Finally, the effectiveness of the theoretical results is demonstrated through a numerical simulation.
Longitudinal study of gut microbiome in obsessive–compulsive disorder

Patients with obsessive–compulsive disorder (OCD) often have limited exposure to a diverse environment and perform repetitive compulsions such as excessive cleaning and washing, which could lead to altered gut microbiome. Therefore, longitudinal studies that investigate changes in gut microbiome before and after cognitive behavioral therapy based on exposure and response prevention (ERP) are warranted.
Barriers to chimpanzee gene flow at the south‐east edge of their distribution

Populations on the edge of a species' distribution may represent an important source of adaptive diversity, yet these populations tend to be more fragmented and are more likely to be geographically isolated. Lack of genetic exchanges between such populations, due to barriers to animal movement, can not only compromise adaptive potential but also lead to the fixation of deleterious alleles. The south‐eastern edge of chimpanzee distribution is particularly fragmented, and conflicting hypotheses have been proposed about population connectivity and viability. To address this uncertainty, we generated both mitochondrial and MiSeq‐based microsatellite genotypes for 290 individuals ranging across western Tanzania. While shared mitochondrial haplotypes confirmed historical gene flow, our microsatellite analyses revealed two distinct clusters, suggesting two populations currently isolated from one another. However, we found evidence of high levels of gene flow maintained within each of these clusters, one of which covers an 18,000 km2 ecosystem. Landscape genetic analyses confirmed the presence of barriers to gene flow with rivers and bare habitats highly restricting chimpanzee movement. Our study demonstrates how advances in sequencing technologies, combined with the development of landscape genetics approaches, can resolve ambiguities in the genetic history of critical populations and better inform conservation efforts of endangered species.
Positive Energy, Negative Energy, Energy-Momentum Tensor and Negative Charge of Gravitational Field

The issues, such as the negative energy density of the gravito-static field and the lack of an energy-momentum tensor in General Relativity (GR), have a long history. To provide possible resolutions for these issues, based on the U (1) gauge theory of gravity, the gravito-static and gravito-magnetic field lines are introduced for the positive/negative gravitational charge and current, respectively. It is shown that the direction of gravitational force acting on a negative gravitational charge is opposite to that of the gravitational field. Then we show that positive energy is stored in the gravitational field and that the exchanged energy between the gravitational field and gravitational charges/currents is always positive. The energy-momentum tensor,T! " ,of the vector gravitational field is introduced and has the following physical properties: (1) symmetric, T! " = T! ; (2) positive energy density, T! > 0; (3) zero trace, T! = 0; (4) conserved,
High-Volume-Rate 3-D Ultrasound Imaging Using Fast-Tilting and Redirecting Reflectors

Three-dimensional ultrasound imaging has many advantages over 2-D imaging such as more comprehensive tissue evaluation and less operator dependence. However, developing a low-cost and accessible 3-D ultrasound solution with high volume rate and imaging quality remains a challenging task. Recently, we proposed a 3-D ultrasound imaging technique: fast acoustic steering via tilting electromechanical reflectors (FASTER), which uses a fast-tilting acoustic reflector to steer ultrafast plane waves elevationally to achieve high-volume-rate 3-D imaging with conventional 1-D transducers. However, the initial FASTER implementation requires a water tank for acoustic wave conduction and cannot be conveniently used for regular handheld scanning. To address these limitations, here, we developed a novel ultrasound probe clip-on device that encloses a fast-tilting reflector, a redirecting reflector, and an acoustic wave conduction medium. The new FASTER 3-D imaging device can be easily attached to or removed from clinical ultrasound transducers, allowing rapid transformation from 2-D to 3-D imaging. In vitro B-mode studies demonstrated that the proposed method provided comparable imaging quality to conventional, mechanical-translation-based 3-D imaging while offering a much faster volume rate (e.g., 300 versus $\sim $ 10 Hz). We also demonstrated 3-D power Doppler (PD) and 3-D super-resolution ultrasound localization microscopy (ULM) with the FASTER device. An in vivo imaging study showed that the FASTER device could clearly visualize the 3-D anatomy of the basilic vein. These results suggest that the newly developed redirecting reflector and the clip-on device could overcome key hurdles for future clinical translation of the FASTER 3-D imaging technology.