Miracle-dz/UniFAR-FTUs huggingface dataset:
The Value of the Capital Market Development-Bursa Research Scheme's (CBRS) Recommendation Changes in

This study analyses the changes in analyst recommendations in the Malaysian stock market from 2010 to 2018. Using samples of 668 upgrade recommendations and 495 downgrade recommendations, this study employs event study methodology to examine price performance by predicting abnormal returns using the market model. The findings indicate that significant positive stock price reactions occur following upgrade recommendations and significant negative stock price reactions occur following downgrade recommendations over a short-term and up to six-month period. Further analysis reveals no statistically significant difference in performance between analysts who are participants of the Capital Market Development Fund – Bursa Research Scheme (CBRS) and those who are not. This finding implies that, despite the significant market reaction to both upgrade and downgrade recommendations, CBRS’s financial analysts do not provide better analysis than those of non-CBRS analysts.
Effect of Electromagnetic Radiation Emitted from Mobile Phone on Electrocardiographic Variables and Rate Pressure Product

Recently peoples are concerned with safety of electromagnetic waves (EMW) emitted from mobile phone (MP) because neurological, degenerative, and heart diseases have been reported to be related with the use of MP. So, it is planned to study the effect of EMW emitted from MP on QT interval variables of electrocardiogram (ECG). Study was carried out in 15 healthy male subjects in the age group of 18–40 years. They were divided into two groups, i.e., MP nonuser group and MP user group. ECG was recorded in lead II for 5 min before and after listening to MP (1800 MHz frequency, band GSM type, model Panasonic GD75) which was held near to ear for a period of 30 min in on position on polyrite D system. On observing the acute effect of EMW emitted from MP, in MP non user group, R-R interval (P <0.001), QTc (p<0.05), P wave duration (p<0.001) and RPP were reduced (p<0.001), whereas R-R interval was reduced (p
Relational Coordination of Workforce Diversity and Firm Performance: The Moderating Effects of Workgroup Autonomy and Multisource Feedback

Organizations have become increasingly diverse in the composition of their workforce, but we still have a limited understanding of the effects of workforce diversity such as differences in age and education on performance at the firm level. As an important step in revealing the underlying processes and moderators for the effects of diversity, most importantly, relational coordination is proposed as an intervening process at the firm level through which diversity in age and education indirectly affects firm performance. Furthermore, I highlight the autonomy and multisource feedback, as critical contingencies that moderate the effects of diversity on relational coordination. Lastly, relational coordination is suggested to enhance both objective financial performance and subjective performance ratings. I tested my theoretical arguments using data from 189 Korean firms in the manufacturing sector, and my hypotheses were generally supported. The present findings offer novel practical and theoretical insights into the effect of workforce diversity on firm performance.
•Italian Journal v. 5-1-2010

The National Research Council Institute of Biometeorology of Bologna (IBIMET-CNR) carried out a study aimed to the safeguard of autochthonous cultivars, through the census of secular olive tree plants, belonging to varieties at extinction risk or located in sites with historical or landscape add value in the Province of Bologna (North Italy) with particular attention to phytometric characters, sanitary status of the plants and the relation with their location characteristics. The presence of ancient plants in a specific site may indicate the absence of limiting factors for olive trees development. Considering the environmental factor values of these locations, a classification of the territory in classes of suitability for the cultivation was defined, with the support of a Geographic Information System (GIS). Ancient olive trees data were also collected and catalogued in an internet site (http://olivisecolari.ibimet.cnr.it) where it is possible to reach a virtual journey through studied olive trees. All plants are supplied with a phytometric card and a visualization on a map providing the exact location. The GIS elaboration of the environmental factors considered for the definition of the suitable lands for olive trees cultivation, identified 3556 ha as suitable, of which 972 ha highly suitable belonging to class I, where olive trees cultivation could be profitable because of suitable land morphology and the possibility of a good mechanization due to low field slopes.
Bavarian animal welfare pilot farms - Labor input by comparison

Kurzfassung The aim of this working time study was to obtain basic data from all 34 monitored farms with different farm activities. Moreover, an overview of the labor management and working conditions in Bavarian livestock husbandries was to be given to assess their national and international level. To collect labor input data, the farmers kept working diaries for 16 weeks over one or more periods (e.g. at least during one whole fattening period, or distributed equally over the whole year), depending on their specialization. They were to enter all working procedures performed during this period. For seven farms the recording quality was evaluated as “unsatisfactory” or “insufficient”. Reliable data on labor input were obtained from the others. For the 12 dairy farms (18–99 cows) a labor input of 42 – 114 working hours (WH) per cow and year was ascertained. Milking, feeding, young cattle care and management required the greatest shares of working time in descending order. Only five farms do not exceed the available labor capacity. Three organic farms keeping 20–52 suckler cows had a labor input of 16–27 WH per cow and year. These are typical results for the herd sizes observed. In the piggeries the organic production method had a bearing on the labor input. Three organic farms keeping breeding sows needed 22–35 WH per sow and year, while four conventional farms had results between 10 and 14 WH per sow und year. Also in the pig fattening activity the one organic farm tested differs substantially (3.7 WH per pig place and year) from the three conventional farms with 0.6–1.1 WH per pig place and year. In pig fattening production, the labor input is between 4 and 98 % of the available work capacity. This was mostly influenced by the volume of production and the better utilization of the housing capacity after moving into a new building. Three farms with laying hens (500– 3,000 hen places) had a decreasing labor input per place und year with increasing herd size. Only 15–30 % of their available work capacity was used.
Longitudinal EEG model detects antisense oligonucleotide treatment effect and increased UBE3A in Angelman syndrome

Abstract Angelman syndrome is a neurodevelopmental disorder caused by deficiency of the maternally inherited UBE3A gene in neurons. Antisense oligonucleotide therapies are under development to reinstate UBE3A protein production. Non-invasive biomarkers to detect target engagement and treatment response are needed to support clinical trials. Delta power measured in the scalp EEG is a reliable biomarker for Angelman syndrome but varies widely across individuals and throughout development, making detection of a treatment effect using single measurements challenging. We utilized a longitudinal dataset of 204 EEG recordings from 56 subjects with Angelman syndrome to develop a natural history model of delta (2–4 Hz) power, with predictors of age, elapsed time, and relative delta power at an initial recording. Using this model, we computed the sample and effect sizes needed to detect a treatment effect in a human clinical trial with 80% power. We applied the same model structure to a mouse model of Angelman syndrome (n = 41) to detect antisense oligonucleotide-mediated treatment effects on absolute delta activity and Ube3a expression. In humans, delta power at a second time point can be reliably predicted using the natural history model. In mice, a treatment effect can be detected after antisense oligonucleotide treatment targeting the Ube3a-antisense transcript through at least 8 weeks post-treatment (P < 1e-15). Deviations in delta power from the expected natural history correlated with Ube3a expression in the mouse model (P < 0.001). Deviations in delta power from a human natural history model in Angelman syndrome can detect antisense oligonucleotide-mediated improvement in Ube3a expression in Angelman syndrome mice and may be relevant for human clinical trials.
Factors associated with eHealth literacy focusing on digital literacy components: A cross-sectional study of middle-aged adults in South Korea

Background Digital technology has dramatically changed the world in which we live, and the ability to access and understand information through these new technologies is becoming increasingly important. eHealth literacy is closely related to digital literacy, and some concepts may overlap to a certain extent. Identifying personal and digital-related factors related to eHealth literacy levels in middle-aged adults would be useful for planning tailored interventions and health promotion strategies. Objective We aimed to identify the differences in digital literacy and eHealth literacy levels according to demographic features, and to elucidate the factors associated with eHealth literacy in the middle-aged population. Methods We conducted a cross-sectional, observational study from 4th to 8th February 2021. A total of 320 South Korean participants aged 40–64 years were recruited and completed an online questionnaire, where demographic features, chronic disease status, frequency of Internet use, digital skills, digital competence, and eHealth literacy were measured. eHealth literacy was measured with the eHEALS. We used multiple regression analysis to elucidate the factors associated with eHealth literacy. Results Multiple regression analysis revealed that digital competence was the highest contributor to an individual's eHealth literacy (β = 0.330, P < 0.001), while digital skills was not significantly associated with eHealth literacy (β = 0.086, P = 0.267). In addition, eHealth literacy was positively associated with increasing age (β = 0.258, P < 0.001), female gender (β = −0.118, P = 0.022), and higher education levels (β = 0.114, P = 0.041), while marital state, chronic disease, and frequency of internet use were not significantly associated with eHealth literacy. Conclusions Our study provides valuable information on digital literacy and eHealth literacy in middle-aged adults and may be used to guide tailored interventions for improving eHealth literacy. Future studies should consider the differences in digital literacy levels across generations when assessing eHealth literacy or planning digital health interventions.
The superior response speed of table tennis players is associated with proactive inhibitory control

Objective To explore the mechanism behind the faster volitional reaction time (RT) of open skill sports athletes from the perspective of proactive inhibitory control, with the hypothesis that the superior response speed of athletes from open skill sports is related to their enhanced capacity for releasing inhibition. Methods Participants were divided into two groups, an experimental group of 27 table tennis players and a control group of 27 non-athletes. By manipulating cue–target onset asynchrony (CTOA) in a simple cue-target detection task, the timing of target presentation occurred in different phases of the disinhibition process. The time needed for disinhibition were compared between groups. Results For the experimental group, RT varied with CTOA at delays less than 200 ms; for CTOAs greater than 200 ms, RTs were not significantly different. For the control group, RT varied with CTOA for delays as long as 300 ms. Conclusions Table tennis players took less time (200 ms) than non-athletes (300 ms) to complete the disinhibition process, which might partly explain their rapid response speed measured in unpredictable contexts. Significance The study provided evidence for disinhibition speed as a new index to assess the capacity of proactive inhibitory control, and provided a new perspective to explore the superior RT of athletes from open skill sports. We also offered support for the fundamental cognitive benefits of table tennis training.
Natural adjuvants (PC and G2) induce activated natural killer cells with NKG2D expression and cytotoxic properties in colorectal cancer

Aim: This study aimed to investigate the effects of natural adjuvants (G2 and PC) to activate natural killer cells in colorectal cancer. Background: Natural killer (NK) cells are an element of the innate immune system that can recognize and kill cancer cells and provide hope for cancer therapy. One of the current methods in cancer immunotherapy is NK cell therapy. Immunotherapy with NK cells has been limited because of the low number and cytotoxicity level of NK cells. Natural adjuvants such as PC and G2 may stimulate the immune system. It seems that these adjuvants could increase cytotoxic NK cells. Methods: Twelve patients with colorectal cancer and six healthy individuals qualified for inclusion in this study. Peripheral blood mononuclear cells (PBMCs) from each patient with two distinctive concentrations (105and 5×104 cells/well) were treated with Interleukin2 (IL2), PC, and G2 adjuvant separately. The NK cell's surface markers, including CD16, CD56, and NKG2D, were evaluated by flow cytometry. The cytotoxicity effect of treated PBMCs as effector cells against NK sensitive cell line (K562) was assessed using the LDH assay method. Results The results revealed a significant increase in the level of CD16+NKG2D+ NK cells in PBMCs treated with the G2 group compared with the control group in CRC PBMC (p<0.001) as well as the normal PBMC group (p < 0.01). In addition, the results indicated a significant increase in the level of CD56+NKG2D+ cells in the PBMC treated with PC (p < 0.05) and G2 (p < 0.001) groups compared with the PBMC group. The cytotoxicity result of PBMC from CRC patients in 10:1 ratio of the effector: target showed that the cells' cytotoxicity in the PBMCs treated with PC (p<0.01) and G2 (p<0.05) was significantly higher than the untreated PBMC. Conclusion: According to the result of this study, it can be stated that the PC and G2 adjuvants could be candidates for inducing cytotoxic natural killer cells.
Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythroblasts

Abstract The aryl hydrocarbon receptor (AHR) plays an important role during mammalian embryo development. Inhibition of AHR signaling promotes the development of hematopoietic stem/progenitor cells. AHR also regulates the functional maturation of blood cells, such as T cells and megakaryocytes. However, little is known about the role of AHR modulation during the development of erythroid cells. In this study, we used the AHR antagonist StemRegenin 1 (SR1) and the AHR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin during different stages of human erythropoiesis to elucidate the function of AHR. We found that antagonizing AHR signaling improved the production of human embryonic stem cell derived erythrocytes and enhanced erythroid terminal differentiation. RNA sequencing showed that SR1 treatment of proerythroblasts upregulated the expression of erythrocyte differentiation-related genes and downregulated actin organization-associated genes. We found that SR1 accelerated F-actin remodeling in terminally differentiated erythrocytes, favoring their maturation of the cytoskeleton and enucleation. We demonstrated that the effects of AHR inhibition on erythroid maturation were associated with F-actin remodeling. Our findings help uncover the mechanism for AHR-mediated human erythroid cell differentiation. We also provide a new approach toward the large-scale production of functionally mature human pluripotent stem cell-derived erythrocytes for use in translational applications.
PREVENTING CHRONIC DISEASE

Introduction Pre-existing comorbid conditions in COVID-19 patients are risk factors for developing severe disease and death. We aimed to determine the association of chronic liver disease (CLD), a comorbid condition, with severity of disease and death among COVID19 patients. Methods We searched for studies reporting COVID-19 outcomes among CLD and non-CLD patients in databases including Medline, EMBASE, ScienceDirect, Google Scholar, and Cochrane Library from inception of the pandemic until February 2022. Risk of bias assessment was conducted by using the Newcastle-Ottawa Scale for assessing the quality of nonrandomized studies in metaanalyses. We conducted a meta-analysis with a random-effects model and reported pooled odds ratios (ORs) with 95% CIs. Results We included 40 studies with 908,032 participants. Most studies were conducted in China and the US. COVID-19 patients with CLD had significantly higher odds of having a severe form of COVID-19 (pooled OR = 2.44; 95% CI, 1.89–3.16) and death (pooled OR = 2.35; 95% CI, 1.85–3.00) when compared with COVID-19 patients without CLD. Conclusion The presence of CLD is significantly related to adverse clinical outcomes among COVID-19 patients in terms of severity and mortality. Clinicians should develop a comprehensive intervention plan to manage these high-risk patients and reduce COVID19–related deaths.
‘He called me out of the blue’: An ethnographic exploration of contrasting temporalities in a social prescribing intervention

Abstract Social prescribing, a way of connecting patients to local services, is central to the NHS Personalised Care agenda. This paper employs ethnographic data, generated with 19 participants between November 2018 and July 2020, to explore the socio‐temporal relations shaping their experiences of a local social prescribing intervention. Our focus is on the ways in which the intervention synchronised with the multitude of shifting, complex and often contradictory ‘timespaces’ of our participants. Our focus on the temporal rhythms of everyday practice allows us to trace a tension between the linearity and long horizon of the intervention and the oft contrasting timeframes of participants, sometimes leading to a mismatch that limited the intervention's impact. Further, we observed an interventional ‘drift’ from continuity towards unsupported signposting and ‘out‐of‐the‐blue’ contacts which favour the temporality of the intervention. We demonstrate a need for intervention planning to be flexible to multiple, often conflicting, temporalities. We argue that health interventions must account for the temporal relations lived by the people they seek to support.
Field assessment of trace element phytoextraction by different Populus clones established on brownfields in southern Quebec (Canada)

Abstract Fast-growing hybrid poplars have been tested for their potential to remove trace elements (TE) from polluted soil in several temperate regions. Despite their potential, they have rarely been tested in countries with a cold temperate climate. The current study screened four different Populus hybrids for phytoextraction of four TEs (i.e., As, Cu, Pb, and Zn) on an abandoned brownfield site in southern Quebec (Canada). The main results showed that under the current experimental conditions, the most important traits determining the actual phytoextraction rate are Biological Concentration Factor (BCF) and TE accumulation in the aboveground biomass, rather than biomass productivity. Although the overall performance of the chosen hybrids was rather poor, the presence of poplar stands enhanced the movement of mobile contaminants in soil, which led to an increase in their concentration in the root zone. This aspect suggests possible strategies for using these plants with high transpiration rates in future phytoremediation projects, including either possible rotation with more effective TE phytoextractor plants (e.g., hyperaccumulators) that can remove high TE amounts that have migrated from the deeper soil layers following poplar plantation, or phytostabilization. NOVELTY STATEMENT Although the use of fast-growing woody species is commonly reported as a feasible option for the phytoextraction of TEs in temperate climates, most available information pertains to only a few species, mostly willows. This is one of the few studies reporting the results of a field test carried out in a cold temperate region, in which different poplar hybrid clones were tested for their potential in TEs phytoextraction. This research determined that although the studied poplar genotypes have no potential under these experimental conditions, the increase in TE concentration observed in the rhizosphere after two years suggests possible alternative phytoremediation strategies (phytostabilization) for managing polluted sites in cold temperate climates.
Exploring key developmental phases and phase‐specific genes across the entirety of anther development in maize

ABSTRACT Anther development from stamen primordium to pollen dispersal is complex and essential to sexual reproduction. How this highly dynamic and complex developmental process is controlled genetically is not well understood, especially for genes involved in specific key developmental phases. Here we generated RNA sequencing libraries spanning 10 key stages across the entirety of anther development in maize (Zea mays). Global transcriptome analyses revealed distinct phases of cell division and expansion, meiosis, pollen maturation, and mature pollen, for which we detected 50, 245, 42, and 414 phase‐specific marker genes, respectively. Phase‐specific transcription factor genes were significantly enriched in the phase of meiosis. The phase‐specific expression of these marker genes was highly conserved among the maize lines Chang7‐2 and W23, indicating they might have important roles in anther development. We explored a desiccation‐related protein gene, ZmDRP1, which was exclusively expressed in the tapetum from the tetrad to the uninucleate microspore stage, by generating knockout mutants. Notably, mutants in ZmDRP1 were completely male‐sterile, with abnormal Ubisch bodies and defective pollen exine. Our work provides a glimpse into the gene expression dynamics and a valuable resource for exploring the roles of key phase‐specific genes that regulate anther development.
A review of caregiver costs included in cost-of-illness studies

ABSTRACT Introduction Economic evaluations typically focus solely on patient-specific costs with economic spillovers to informal caregivers less frequently evaluated. This may systematically underestimate the burden resulting from disease. Areas covered Cost-of-illness (COI) analyses that identified costs borne to caregiver(s) were identified using PubMed and Embase. We extracted study characteristics, clinical condition, costs, and cost methods. To compare caregiver costs reported across studies, estimated a single ‘annual caregiver cost’ amount in 2021 USD. Expert opinion A total of 51 studies met our search criteria for inclusion with estimates ranging from $30 – $86,543. The majority (63%, 32/51) of studies estimated caregiver time costs with fewer studies reporting productivity or other types of costs. Caregiver costs were frequently reported descriptively (69%, 35/51), with fewer studies reporting more rigorous methods of estimating costs. Only 27% (14/51) of studies included used an incremental analysis approach for caregiver costs. In a subgroup analysis of dementia-focused studies (n = 16), we found the average annual cost of caregiving time for patients with dementia was $30,562, ranging from $4,914 to $86,543. We identified a wide range in annual caregiver cost estimates, even when limiting by condition and cost type.