Miracle-dz/UniFAR-FTUs huggingface dataset:
Sodium-Glucose Cotransporter 2 Inhibitor Use Among Individuals Age <65 with Type 2 Diabetes and Heart Failure with Reduced Ejection Fraction: A Cost–Benefit Analysis

Background Type 2 diabetes (T2D) patients face increased risk of heart failure (HF) as they age. Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) have demonstrated effectiveness in reducing HF hospitalizations in patients with T2D and HF with reduced ejection fraction (HFrEF). Diabetes guidelines recommend SGLT-2i therapy for patients with HFrEF; however, SGLT-2i cost is high. Objective Study objectives were to assess SGLT-2i utilization and HF hospitalization rates in commercially insured adults (age <65) with T2D and heart failure with reduced ejection fraction (HFrEF) taking metformin with/without SGLT-2i use and conduct a cost–benefit analysis of SGLT-2i use from payer and societal perspectives. Methods Economic models included HF hospitalization rates from real-world data (RWD) and hospitalization rate reductions from RWD and SGLT-2i clinical trials. Real-world HF hospitalization rates were obtained from claims data (MarketScan Commercial Database, years 2013–2018). Societal perspective analyses included indirect costs. Sensitivity analyses were conducted on key parameters. Results Among adults with T2D and HFrEF age 30–64, SGLT-2i use increased (1.1% to 17.4%) between 2013 and 2018. The HF hospitalization rate without SGLT-2i use vs with was 15.5% vs 11.0% (absolute risk reduction of 4.5%). Base case scenario net-benefit was negative across all payer perspective models, while positive for societal-perspective. Payer perspective overall net-benefit in 30–64 population: −$1,725,758 (−$4106 per person). Societal perspective net-benefit in 30–64 population: $5,996,851 ($14,269 per person). In sensitivity analyses, estimated per person base case societal net-benefit of $14,269 was most sensitive to changes in baseline HF hospitalization rates, post-discharge mortality rates, and readmission rates. Lowering SGLT-2i prescription costs 50% and 80% resulted in per person net-benefit increases of $1737 and $4004, respectively. Conclusion SGLT-2i utilization has steadily increased, with lower HF hospitalization rates observed among SGLT-2i users. Societal benefits of SGLT-2i use in this population are substantive; payer benefits are negative unless SGLT-2i cost is drastically reduced.
From Alpha to Delta—Genetic Epidemiology of SARS-CoV-2 (hCoV-19) in Southern Poland

In Poland, the first case of SARS-CoV-2 infection was confirmed in March 2020. Since then, many circulating virus lineages fueled rapid pandemic waves which inflicted a severe burden on the Polish healthcare system. Some of these lineages were associated with increased transmissibility and immune escape. Mutations in the viral spike protein, which is responsible for host cell recognition and serves as the primary target for neutralizing antibodies, are of particular importance. We investigated the molecular epidemiology of the SARS-CoV-2 clades circulating in Southern Poland from February 2021 to August 2021. The 921 whole-genome sequences were used for variant identification, spike mutation, and phylogenetic analyses. The Pango B.1. 1.7 was the dominant variant (n = 730, 89.68%) from March 2021 to July 2021. In July 2021, the B.1. 1.7 was displaced by the B.1. 617.2 lineage with 66.66% in July 2021 and 92.3% in August 2021 frequencies, respectively. Moreover, our results were compared with the sequencing available on the GISAID platform for other regions of Poland, the Czech Republic, and Slovakia. The analysis showed that the dominant variant in the analyzed period was B.1. 1.7 in all countries and Southern Poland (Silesia). Interestingly, B.1. 1.7 was replaced by B.1. 617.2 earlier in Southern Poland than in the rest of the country. Moreover, in the Czech Republic and Slovakia, AY lineages were predominant at that time, contrary to the Silesia region.
Eddy-Induced Heat Transport in the Subtropical North Pacific from Argo, TMI, and Altimetry Measurements

Basin-scale heat transport induced by mesoscale oceanic eddies is estimated by combining satellite- derived sea surface height and temperature [temperature data are from the TRMM Microwave Imager (TMI)] data with Argo float temperature–salinity data. In the North Pacific Ocean subtropical gyre, warm (cold) temperature anomalies of mesoscale eddies are found to be consistently located to the west of high (low) SSH anomalies. The phase misalignment between the temperature and velocity anomalies, however, is largely confined to the seasonal thermocline, causing most of the eddy-induced heat transport to be carried in the surface 200-m layer. By establishing a statistical relationship between the surface and depth- integrated values of the eddy heat transport, the basin-scale eddy heat transport is derived from the concurrent satellite SSH/SST data of the past six years. In the Kuroshio Extension region, the meandering zonal jet is found to generate oppositely signed eddy heat fluxes. As a result, the zonally integrated poleward heat transport associated with the Kuroshio Extension is at a level O (0.1 PW), smaller than the previous estimates based on turbulent closure schemes. Large poleward eddy heat transport is also found in the subtropical North Pacific along a southwest–northeast-tilting band between Taiwan and the Midway Islands. This band corresponds to the region of the subtropical front, and it is argued that the relevant temperature field for identifying this band in the turbulent closure scheme models should be that averaged over the seasonal thermocline.
The impact of diet-protein content in telomarase regulation

: Higher telomere length (TL) is associated with longevity, while telomeres shortening are related with some non-communicable diseases (NCDs) such as cancer or cardiovascular disease, and with higher risk of mortality. Telomerase RNA component (TERC) and peroxiredoxin-1 (PRDX1) are involved in the regulation of Telomerase, an enzyme capable to extent TL. Diet could play a role in telomere shortening by regulation of cellular oxidative stress and by modulate the expression of certain genes involved in Telomerase Activity (TA) as presented before. This paper study how low-protein diet (LPD) and leucine deprivation (LEU(-)) in tandem with fibroblast growth factor 21 (FGF21) can affect the relative gene expression of Terc and Prdx1 in mice. Murines with and without FGF21 were fed with LPD and LEU(-), with corresponding Control Diet (CD) group for each one. Relative liver mRNA levels of Terc and Prdx1 were determined by RT-qPCR. Results suggested that diet-protein content and FGF21 could impact on Terc and Prdx1 expression by modulating oxidative stress of the cell. LPD synergized with FGF21 to increase Prdx1 mRNA levels (p=0.00096), but inconsistency and the contradictions of the findings did not allow to suggest accurate conclusions and for that reason further investigations with better designs are needed.
Sociobiology Linking bird resistant and susceptible sunflower traits with pollinator’s fauna and seed production

Sunflower ( Helianthus annus L.) is a highly cross-pollinated crop dependent on insect pollinators to provide a good quality edible oil worldwide. Different sunflower hybrids vary in terms of dependence on insect pollinators. Previously few studies have been conducted regarding the role of insect pollinators in hybrid sunflower seed production in Pakistan. Therefore, the current study was planned to explore the abundance and diversity along with foraging behavior (visitation rate and stay time) of native insect pollinators as well as to study the effect of different pollination treatments (free insect visits vs. no insect visits) on the reproductive success of different hybrids of sunflower. Two sunflower hybrids were grown at the research farm of MNS University of Agriculture, Multan, under the Randomized Complete Block Design (RCBD). In our study, the pollinator community consisted of honeybees ( Apis dorsata, A. mellifera, and A. florea ), solitary bees ( Pseudapis sp. , Megachilidae sp. and Xylocopa sp.), and syrphid flies ( Eristalinus aeneus and E. megacephalus ). Furthermore, the relative abundance of pollinators was high in the H4 (bird resitant) having a flat head with 45º head angle from the stem hybrid, while the least abundance was observed in H3 (bird susceptible 180º head angle from stem). H4 proved to be a better hybrid among the hybrids regarding the number of seeds and seed weight. Both bees, i.e., solitary bees and honeybees, are crucial for pollinating sunflower. Comparative results of free insect visits and no insect visit treatments showed that the maximum number of seed weight, number of seeds, and seed diameter was observed in free insect visits compared to no insect visit treatment. Therefore, conserving the diversity of the native insect pollinators will lead to a higher yield of sunflower hybrids and other cross-pollinated crops.
Remote Sensing of Environment

It has been widely reported that Arctic sea ice has decreased in both extent and thickness, coupled with steadily rising mean annual temperatures. These trends have been particularly severe along the rock coast of southern Svalbard. Concerns have been raised over the potential for higher energy storms and longer ice-free open water seasons to increase the exposure of Arctic coasts, and consequently the concentration of infrastructure critical to Arctic community survival, to enhanced rates of erosion. Here we present and apply innovative remote sensing, monitoring and process analyses to assess the impact of recent coastal climatic changes. High resolution analyses demonstrate that the small scale (< 0.001m) changes that are rarely considered quantitatively exhibit geomorphic responses distinct from those of larger, more readily detected cliff failures. We monitor temperature depth profiles in both the shore platform and the cliff face to show rock sensitivity over time to both global and local influences. The results demonstrate the efficacy of thermal processes on Arctic rock cliffs relative to platforms, and may hold implications for understanding strandflat development rates. New three-dimensional thermography (thermal mapping) and process zone characterisation has been used to spatially assess the sensitivity of Arctic rock coast responses to contemporary processes on deglaciating coasts. Through the spatial and temporal analyses of key geomorphic behaviour zones and comparison over a range of sites, the complex and changing interplay between subaerial weathering and cryogenic and intertidal processes has been highlighted. These data challenge long standing assumptions over the future of Arctic rock coasts and identify new, focused lines of enquiry on the decline in cryogenic processes and understanding the sensitivity of Arctic rock coasts to
On the distribution of Kummer sums.

In [9] Papers 16, 17 Kummer considered the problem of the evaluation of G(c) when c is a prime. He found a method for Computing G(c) and from the results of bis computations tried to identify a rule similar to that found by Gauss for the quadratic Gauss sums. He found no such rule, nor has anyone eise since then. One should note, however, that Cassels [3] has given a remarkable conjecture which expresses G(c) s a product but which, unfortunately, gives no real insight into the argument of G(c).
Evaluation of Growth Performance of Three Strains of Nile Tilapia Oreochromis niloticus (L., 1758) Reared in Brackishwater Ponds and Relationship of Growth with Water Physicochemical Parameters

This study was executed to resolve the argument on the growth superiority of three Nile tilapia strains viz . , the existing strain of Nile tilapia (ESNT), genetically improved farmed tilapia (GIFT), and sex-reversed Monosex cultured in brackishwater pond and to comprehend the relationship of water physicochemical parameters with growth. The analogous age group of fish each weighing 0.62±0.09 g with iso-stocking density (5ind./m 2 ) and 120 days culture tenure was considered. The physicochemical variables were at an optimal level over the entire culture period. However, dissolved oxygen had strong positive correlation (r=0.742, p=0.022) and ammonia showed strong negative correlation (r= -0.822, p=0.007) with mean fish weight. The study revealed that weight gain by GIFT strain was nearly 25.9% and 5.10% higher than Monosex and ESNT strain, respectively. The highest final mean body weight was achieved in the GIFT strain (223±8.60 g) and there was a significant difference among the strains. The GIFT strain scored the highest SGR of 16.85%/day with no significant variance across the strain. GIFT strain gave significantly ( p <0.05) higher gross fish yield (9789.70 Kg ha -1 ) along with best FCR (1.23) and survival (87.80%), and differed significantly among the three strains. The ESNT strain showed the closest isotropic growth while the other two had allotropic growth patterns. Thereby, the results established that strain difference significantly ( p <0.05) impacted the growth parameters, and GIFT was the best strain. Overall results greatly minimize the controversy on the growth pattern of different strains of Nile tilapia reared in brackishwater ponds, Bangladesh.
Balmer jump temperature determination in a large sample of low-metallicity H II regions (cid:1),(cid:1)(cid:1),(cid:1)(cid:1)(cid:1)

Aims. Continuing the systematic determination of the electron temperature of H ii regions using the Balmer and / or Paschen disconti-nuities by Guseva et al. (2006, ApJ, 644, 890) we focus here on 3.6 m ESO telescope observations of a large new sample of 69 H ii regions in 45 blue compact dwarf (BCD) galaxies. This data set spans a wide range in metallicity ( Z (cid:2) / 60 < ∼ Z < ∼ Z (cid:2) / 3) and, combined with the sample of 47 H ii regions from Guseva et al. (2006), yields the largest spectroscopic data set ever used to derive the electron temperature in the H + zone. Methods. In the same way as in Guseva et al. (2006) we have used a Monte Carlo technique to vary free parameters and to calculate a series of model spectral energy distributions (SEDs) for each H ii region. The electron temperature in the H + zones was derived from the best ﬁtting synthetic and observed SEDs in the wavelength range ∼ 3200–5100 Å, which includes the Balmer jump. Results. On the base of the present large spectroscopic sample we ﬁnd that in hot ( T e (H + ) > ∼ 11 000 K) H ii regions the temperature of the O 2 + zone, determined from doubly ionised oxygen forbidden lines, does not di ﬀ er statistically from the temperature of the H + zone. Thus, we conﬁrm and strengthen the ﬁnding by Guseva et al. (2006). We emphasize that due to a number of modelling assumptions and the observational uncertainties for individual objects, only a large, homogeneous sample, as the one used here, can enable a conclusive study of the relation between T e (H + ) and T e (O iii ).
Library-school collaboration. A case study of teacher thematic interests in loan requests i

Partnerships between public libraries and schools foster reading literacy. In view of this fact, many libraries implement actions for this purpose. This paper analyses the implementation of the initiative called “Library-School Programme” of the Civican library, an entity dependent on the Caja Navarra Foundation and part of the Network of Public Libraries of Navarre (Spain). This case study scrutinised the 804 book loan requests made by pre-school, primary, and secondary school teachers under the program between 2007 and 2021. It aims at discovering the educational stages with the highest demand, the most reoccurring reasons for the requests, and the evolution of the service. Research - of a descriptive statistical nature - shows greater participation in Pre-school and Primary Education, as well as a progressive reduction in the number of loans for these stages, with the opposite trend in Secondary Education. The findings of this study suggest directions for public libraries, schools, and administration to improve their collaboration strategies.
An Assessment of Customer-Centricity Success Factors: Context of the Lebanese Market

Abs tract- Acade mically, in the context of the Lebanese market, customer-centricity has not been addressed earlier; the factors that drive the success of a customer-centric strategy for an organization are to be recognized. An organization needs to identify and define the benefit and critical success factors (CSFs) of having the customer as the driver for its operations. A customer-centric organization capitalizes on an operating model based on a deep understanding of its customers, what they value, and what contribution they make to the company's profitability. This paper aims to assess and analyze the critical success factors of organizational customer-centricity within the context of the Lebanese market. It follows a quantitative approach with data collected from survey questionnaires administered to different employees of different organizations in various Lebanese regions. Abstract- Academically, in the context of the Lebanese market, customer-centricity has not been addressed earlier; the factors that drive the success of a customer-centric strategy for an organization are to be recognized. An organization needs to identify and define the benefit and critical success factors (CSFs) of having the customer as the driver for its operations. A customer-centric organization capitalizes on an operating model based on a deep understanding of its customers, what they value, and what contribution they make to the company's profitability. This paper aims to assess and analyze the critical success factors of organizational customer-centricity within the context of the Lebanese market. It follows a quantitative approach with data collected from survey questionnaires administered to different employees of different organizations in various Lebanese regions. A customer-centricity proposition in the Lebanese market was formulated based on data analysis. The Statistical Product and Process Solution (SPSS) used descriptive and inferential statistics for data processing. Results reported in different forms include pie charts, t-tests, chi-square tests, cross-tabulation, and regression analysis. The general proposition based on the findings reflects the research's objectives, revealing that Lebanese organizations should capitalize on the internal factors of importance such as leadership, culture, and structure within a customer-centric strategy. These factors will complement other external factors that will ensure the success of this strategy.
Beet-arugula intercropping under green manuring and planting density induce to agro-economic advantages

One of the biggest challenges in the intercropping system of two crops is to obtain the optimal dose of green manure and the adequate population density of the crops. So, the objective of this work was to evaluate the performance of beet and arugula intercropping, influenced by green manuring with Merremia aegyptia and Calotropis procera and arugula population densities in two cultivation years, in semi-arid environment. The experimental design used was in randomized complete blocks, with the treatments arranged in a 4 x 4 factorial scheme, with 4 repetitions. The first factor of this scheme consisted of equitable amounts of M. aegyptia and C. procera biomass (20, 35, 50 and 65 t ha -1 on a dry basis) and the second factor, by arugula population densities (40, 60, 80 and 100% of the recommended density for single cropping, corresponding to 400, 600, 800 and 1,000 thousand arugula plants ha -1 ). The production and its components were evaluated on beet and arugula. In addition to these characteristics, the following agro-economic indicators were also determined for each treatment: system productivity index (SPI), land equivalent coefficient (LEC) and monetary equivalent ratio (MER). The greatest agro-economic advantages of the beet with arugula intercropping were achieved with a system productivity index (SPI) of 53.47 t ha -1 , land equivalent coefficient (LEC) of 0.84 and a monetary equivalent ratio (MER) of 1.56, respectively, combining 65 t ha -1 of M. aegyptia and C. procera biomass with the arugula population density of 1,000 thousand plants ha -1 . The maximum optimized commercial productivity of beetroots in the system intercropped with arugula was 23.20 t ha -1 using 65 t ha -1 of M. aegyptia and C. procera and in the arugula population density of 1,000 thousand plants ha -1 , while the maximum arugula productivity intercropped with beet was 9.65 t ha -1 , in the same combination of green manures amount and arugula population density.
Organizational Strategic Intuition for High Performance: The Role of Knowledge-Based Dynamic Capabilities and Digital Transformation

This study investigated the role of organizational strategic intuition (OSI) and relationships with knowledge-based dynamic capabilities (KBDCs), digital transformation (DT), and high-performance organizations (HPOs). This quantitative study used a questionnaire to collect data from chief executive officers (CEOs) and engineers of various companies in the auto parts industry, a crucial income-generator for Thailand. Partial least squares structural equation modeling, which assesses reflective and structural models, was adopted to test the hypotheses. The findings revealed significant influences among the six pairs of constructed relationships. Indeed, investigations found in this study indicated that (1) KBDCs had a positive effect on DT; (2) KBDCs and DT had a positive effect on OSI; and (3) KBDCs, DT, and OSI had a positive effect on HPOs. The analytical results of this empirical study also provided information to expand the knowledge of strategic intuition (SI). The practical contribution of this study is a consolidated comprehensive framework of OSI that contained vital insights for CEOs, policymakers, and practitioners to support the creation of OSI, leading to better strategic decisions.
From Self-Doubt to Pride: Understanding the Empowering Effects of Delivering School-Based Wellness Programmes for Emerging Adult Facilitators—A Qualitative Study

Ample literature exists on the impact of prevention programmes on their target audience, while much less is known about how delivering such programmes influences their facilitators. Even less literature exists on the emotional and social processes that form this potential impact on facilitators. The current study analysed qualitative in-depth, non-structured interviews, as well as written essays provided by 33 student-facilitators who delivered the “Favoring Myself” programme in Israel during 2019–2021. This school-based wellness programme comprised 10 weekly, 90 min sessions on self-care behaviours, media literacy, self-esteem, and positive body image, which are well-known protective factors against risky behaviours. A thematic analysis was applied to explore the main themes in the collected data. An interesting affective transformation from self-doubt to pride in themselves emerged as a shared experience of these young facilitators. Facilitators related their ability to facilitate the programme, as well as to undergo an individual maturation and empowerment experience, to certain components of the programme itself, such as the preparatory course, individual supervision, and the peer-group experience. This shift from doubt to pride is discussed using two frameworks—a theoretical discourse of emerging adulthood as a developmental stage, and the self-determination theory.