Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients

Objective Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the expression of caspase-3 and caspase-9 in schizophrenia patients and healthy samples. Methods RNA was isolated from the peripheral blood of 39 schizophrenia patients’ and healthy samples. After cDNA synthesis, real time PCR (RT-PCR) was used to analyse caspase-3 and caspase-9 gene expression. The severity of psychopathological symptoms of schizophrenia was evaluated using the Positive and Negative Symptoms Scale for schizophrenia (PANSS) and Clinical Global Impressions (CGI). Results The expression of caspase-3 and caspase-9 genes was higher in schizophrenia patients than in healthy samples (p = 0.012, p = 0.002, respectively). The increase in caspase-3 gene expression was significant with being male, smoking and with a duration of less than 6 years (p = 0.047, p = 0.049, p = 0.034, respectively). On the other hand, the increase in caspase-9 gene expression was significant in patients who is smoke, have children, and are under 33 years old (p = 0.040, p = 0.043, p = 0.045, respectively). A significant positive correlation was detected between the caspase-3 and caspase-9 gene expression (r = 0.3218, p = 0.049). Conclusion Our findings indicate that caspase-3 and caspase-9 gene expression may activate cell death mechanisms by intrinsic apoptotic genes. Furthermore, caspase-3 and caspase-9 may play essential roles in different ways in schizophrenia. Hence there is a need to further study the apoptotic mechanism with expanded patient populations.
Multiple Indicator Stationary Time Series Models

This article is intended to complement previous research (Sivo, 1997; Sivo & Willson, 1998, in press) by discussing the propriety and practical advantages of specifying multivariate time series models in the context of structural equation modeling for time series and longitudinal panel data. Three practical considerations motivated this article. Unlike Marsh (1993), Sivo and Willson (2000) did not offer multiple indicator (latent order) equivalents to their autoregressive (AR), moving average (MA), and autoregressive-moving average (ARMA) models. Moreover, such models have yet to be discussed, despite Marsh's (1993) advocacy for multiple indicator models in general. Further motivating multiple indicator extensions of the AR, MA, and ARMA equivalent models is the fact that longitudinal studies often collect data on more than 1 related variable per occasion. Such multiple indicator models capitalize on 1 of the chief analytical advantages of structural equation modeling in that measurement error may be estimated directly.
Fear of making a mistake: a prominent cause of stress for COVID-19 ICU staff—a mixed-methods study

Introduction The COVID-19 pandemic has had a profound effect on many domains of healthcare. Even in high-income countries such as Sweden, the number of patients has vastly outnumbered the resources in affected areas, in particular during the first wave. Staff caring for patients with COVID-19 in intensive care units (ICUs) faced a very challenging situation that continued for months. This study aimed to describe burnout, safety climate and causes of stress among staff working in COVID-19 ICUs. Method A survey was distributed to all staff working in ICUs treating patients with COVID-19 in five Swedish hospitals during 2020 and 2021. The numbers of respondents were 104 and 603, respectively. Prepandemic data including 172 respondents from 2018 served as baseline. Results Staff exhaustion increased during the pandemic, but disengagement decreased compared with prepandemic levels (p<0.001). Background factors such as profession and work experience had no significant impact, but women scored higher in exhaustion. Total workload and working during both the first and second waves correlated positively to exhaustion, as did being regular ICU staff compared with temporary staff. Teamwork and safety climate remained unchanged compared with prepandemic levels. Respondents reported ‘making a mistake’ as the most stressful of the predefined stressors. Qualitative analysis of open-ended questions identified ‘lack of knowledge and large responsibility’, ‘workload and work environment’, ‘uncertainty’, ‘ethical stress’ and ‘organization and teamwork’ as major causes of stress. Conclusion Despite large workloads, disengagement at work was low in our sample, even compared with prepandemic levels. High levels of exhaustion were reported by the ICU staff who carried the largest workload. Multiple significant causes of stress were identified, with fear of making a mistake the most significant stressor.
Evaluation of implantable collamer lens sizing developed by reviewing the horizontal compression-vault coefficient

To evaluate the ICL-sizing method using the partial regression coefficient of the implanted ICL size to review the horizontal compression-vault coefficient and match the results of clinical observation. Purpose: To evaluate the implantable collamer lens (ICL)–sizing method using the partial regression coefficient of the implanted ICL size to review the conventional horizontal compression coefficient and match the results of clinical observation. Setting: Nagoya Eye Clinic, Nagoya, Japan. Design: Interventional case series. Methods: Patients who underwent ICL V4c implantation to correct myopia and myopic astigmatism were enrolled. The stepwise multiple regression analysis used achieved vault as a dependent variable and preoperative biometric parameters as explanatory variables. The partial regression coefficient of the implanted ICL size was obtained to develop the optimal ICL-sizing formula, the Nakamura-Kojima formula version 3 (NK-formula V3). 85 eyes of 45 patients were implanted with an ICL size recommended by the NK-formula V3. At 3 months postoperatively, the achieved vault was measured using anterior segment optical coherence tomography to validate the NK-formula V3. Results: The study enrolled 174 patients (174 eyes). The partial regression coefficient of the implanted ICL size adopted as the compression-vault coefficient in the multiple regression equation predicting the vault was 0.729. To validate the NK-formula V3, 77 (90.6%), 7 (8.2%), and 1 (1.2%) eyes were in the moderate-vault, low-vault, and high-vault categories, respectively. The mean difference between the achieved and predicted vaults was 0.064 ± 0.190 (range: −0.264 to 0.742) mm for the NK-formula V3 and 0.176 ± 0.217 (range: −0.254 to 0.907) mm for the NK-formula V2. Conclusions: As in vivo coefficient measurement experiments are not possible, the partial regression coefficient is the best option for developing a formula to predict the optimal ICL size.
Diversity and Quantitative Detection of Clade I Type nosZ Denitrifiers in the Arabian Sea Oxygen Minimum Zone

A significant amount of nitrous oxide (N2O) is effluxed into the atmosphere as a result of marine denitrification in the Arabian Sea (AS) oxygen minimum zone (OMZ). An assessment of temporal variations in the diversity and abundance of nosZ denitrifiers was performed to establish the relative importance of these bacteria in denitrification. Sampling was conducted at the Arabian Sea Time Series (ASTS) location and a quantitative PCR (qPCR) analysis was performed. We detected a high abundance of the nosZ gene at core OMZ depths (250 m and 500 m), indicating the occurrence of denitrification in the AS-OMZ. The maximum abundance of the nosZ gene was observed during the Spring Intermonsoon (SIM) at 250 m (1.32×106 copies L–1) and 500 m (1.50×106 copies L–1). Sequencing analysis showed that nosZ denitrifiers belonged to the classes Alpha-, Beta-, and Gammaproteobacteria. Taxonomic analysis revealed that most OTUs were affiliated with Pseudomonas, Rhodopseudomonas, and Bradyrhizobium. Diversity indices and richness estimators confirmed a higher diversity of nosZ denitrifiers at 250 m than at 500 m during all three seasons. The present results also indicated that dissolved oxygen (DO) and total organic carbon (TOC) are critical factors influencing the diversity and abundance of the nosZ-denitrifying bacterial community.
Stabilizing the retarded potential method for transient fluid–structure interaction problems

The Retarded Potential (RP) method, which is a boundary element technique and non-local in both space and time, is employed to discretize the fluid domain for the analysis of transient fluid–structure interaction problems. The retarded potential analysis program RPFS is coupled to the ABAQUS non-linear finite element code to form ABAQUS/RPFS. The standard RP is inherently unstable for time steps below a critical time step that is equal to the maximum distance in the fluid divided by the wave speed. A technique referred to as the Figueiredo method is used to convert the standard RP differential-delay equations for the fluid to simply delay equations, which are more stable. The Figueiredo approach extends the stability range of the standard RP by a factor of approximately 10–20, but this time step is still not small enough to be useful for analysis. Digital signal processing methods are used to further stablize the response of the fluid by removing the oscillating high-frequency noise in the time histories of the solution without introducing phase shifting or any significant damping. Stability of the coupled system is achieved by not extrapolating the structural accelerations. ABAQUS/RPFS is applied to both a rigid and elastic sphere subjected to a plane wave, and the results using the full time histories required are completely stable and quite accurate. With this procedure, the retarded potential method may yet prove to be a valuable analysis tool for transient fluid–structure interaction problems. © 1997 John Wiley & Sons, Ltd.
Reduced-Bias Tail Index Estimators Under a Third-Order Framework

In this article, we are interested in the comparison, under a third-order framework, of classes of second-order, reduced-bias tail index estimators, giving particular emphasis to minimum-variance reduced-bias estimators of the tail index γ. The full asymptotic distributional properties of the proposed classes are derived under a third-order framework and the estimators are compared with other alternatives, not only asymptotically, but also for finite samples through Monte Carlo techniques. An application to the log-exchange rates of the Euro against the USA Dollar is also provided.
Electrophoresis of a small sphere in a cylinder of finite length

The pressure due to electrophoretic motion of a charged colloidal sphere in a fluid‐filled circular cylinder is determined in the limit in which the sphere radius is small compared with that of the cylinder. If the ends of the cylinder are open, pressure‐driven Poiseuille flow occurs, but the magnitude of this flow is shown to be small when the cylinder is long compared to its radius. It is concluded that the flow has little effect upon electrophoretic velocities, unlike when the diameter of the sphere is comparable to that of the cylinder in which case the Poiseuille flow increases electrophoretic velocities and creates long‐range interactions between spheres.
North Atlantic surface ocean warming and salinization in response to middle Eocene greenhouse warming

Quantitative reconstructions of hydrological change during ancient greenhouse warming events provide valuable insight into warmer-than-modern hydrological cycles but are limited by paleoclimate proxy uncertainties. We present sea surface temperature (SST) records and seawater oxygen isotope (δ18Osw) estimates for the Middle Eocene Climatic Optimum (MECO), using coupled carbonate clumped isotope (Δ47) and oxygen isotope (δ18Oc) data of well-preserved planktonic foraminifera from the North Atlantic Newfoundland Drifts. These indicate a transient ~3°C warming across the MECO, with absolute temperatures generally in accordance with trace element (Mg/Ca)–based SSTs but lower than biomarker-based SSTs for the same interval. We find a transient ~0.5‰ shift toward higher δ18Osw, which implies increased salinity in the North Atlantic subtropical gyre and potentially a poleward expansion of its northern boundary in response to greenhouse warming. These observations provide constraints on dynamic ocean response to warming events, which are consistent with theory and model simulations predicting an enhanced hydrological cycle under global warming.
Prevalence, outcomes, and predictors of multidrug-resistant nosocomial lower respiratory tract infections among patients in an ICU

ABSTRACT Objective: To determine the prevalence, outcomes, and predictors of multidrug-resistant nosocomial lower respiratory tract infections (LRTI) in patients in an ICU. Methods: This was an observational cohort study involving patients with nosocomial LRTI (health care-associated pneumonia, hospital-acquired pneumonia, or ventilator-associated pneumonia). Data were prospectively collected between 2015 and 2019. The multidrug-resistant pathogens (MDRPs) identified in the isolates studied included resistant to extended-spectrum cephalosporin-resistant and carbapenem-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa, carbapenem-resistant Enterobacteriaceae, and methicillin-resistant Staphylococcus aureus at microbiological diagnosis. Results: During the study period, 267 patients in the ICU were diagnosed with LRTI, microbiological confirmation of LRTI having been obtained in 237. Of these, 146 (62%) had at least one MDRP isolate. Patients infected with MDRP were found to have poorer outcomes than patients infected with susceptible strains, such as prolonged mechanical ventilation (18.0 days vs. 12.0 days; p < 0.001), prolonged ICU length of stay (23.0 days vs.16.0 days; p < 0.001), and higher mortality (73% vs. 53%; p < 0.001) when compared with patients infected with susceptible strains. Hospital length of stay ≥ 5 days (OR = 3.20; 95% CI: 1.39-7.39; p = 0.005) and prolonged use vasoactive drugs (OR = 3.15; 95% CI: 1.42-7.01; p = 0.004) were independent predictors of LRTI caused by MDRPs (LRTI-MDRP). The presence of LRTI-MDRP was found to be an independent predictor of death (OR = 2.311; 95% CI: 1.091-4.894; p = 0.028). Conclusions: Prolonged use of vasoactive drugs and prolonged hospital length of stay were independent predictors of LRTI-MDRP in this population of critically ill patients with very poor outcomes.
THE EFFECTS OF CHRONIC PERIODONTITIS AND OBESITY ON TOTAL ANTIOXIDANT/OXIDANT STATUS AND OXIDATIVE STRESS INDEX.

Objective Both obesity and periodontal diseases are significant diseases that affect the quality of life. Recent studies have focused on the relationship between obesity and periodontal disease. The aim of this study is to determine the pathophysiological relationship between obesity and periodontal disease by evaluating the clinical periodontal parameters and oxidative status. Subjects and Methods The study included 80 individuals divided into four groups including 20 individuals in each group as following; periodontally healthy patients with normal weight, (NH), patients with chronic periodontitis and normal weight (NCP), periodontally healthy patients with obesity (OH) and patients with chronic periodontitis and obesity (OCP). Clinical periodontal parameters were recorded, and serum, saliva and gingival crevicular fluid (GCF) samples were obtained. Local and systemic levels of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) were assessed biochemically. Results No statistically significant difference was found among the groups regarding TAS, TOS and OSI values in serum and saliva samples (p>0.05). GCF-TAS values in NH group were statistically significantly higher compared with other groups (p<0,05) . GCF TOS values increased in obese groups (OH, OCP) compared with non-obese groups (NH, NCP) (p<0.05). Our results suggest that obesity and chronic periodontitis do not effect oxidant/antioxidant levels in serum and saliva. Conclusions Many factors such as daily living conditions of the individual, stress and nutritional habits TAS and TOS levels of the individual may affect oxidative stress parameters. However, these factors could not be standardized in the study.
Multiple sclerosis and circadian rhythms: Can diet act as a treatment?

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system (CNS) with increasing incidence and prevalence. MS is associated with inflammatory and metabolic disturbances that, as preliminary human and animal data suggest, might be mediated by disruption of circadian rhythmicity. Nutrition habits can influence the risk for MS, and dietary interventions may be effective in modulating MS disease course. Chronotherapeutic approaches such as time‐restricted eating (TRE) may benefit people with MS by stabilizing the circadian clock and restoring immunological and metabolic rhythms, thus potentially counteracting disease progression. This review provides a summary of selected studies on dietary intervention in MS, circadian rhythms, and their disruption in MS, including clock gene variations, circadian hormones, and retino‐hypothalamic tract changes. Furthermore, we present studies that reported diurnal variations in MS, which might result from circadian disruption. And lastly, we suggest how chrononutritive approaches like TRE might counteract MS disease activity.
CONTACT GEOMETRY AND RICCI SOLITONS

We show that a compact contact Ricci soliton with a potential vector field V collinear with the Reeb vector field, is Einstein. We also show that a homogeneous H-contact gradient Ricci soliton is locally isometric to En+1 × Sn(4). Finally we obtain conditions so that the horizontal and tangential lifts of a vector field on the base manifold may be potential vector fields of a Ricci soliton on the unit tangent bundle.
Convergence Rates of a Regularized Newton Method in Sound-Hard Inverse Scattering

The iteratively regularized Gauss--Newton method is used to solve an inverse acoustic scattering problem with Neumann boundary conditions in two space dimensions, which is known to be nonlinear and severely ill posed. Some recent results on the speed of convergence for such problems are considered, and numerical experiments yield logarithmic convergence rates, as expected. Moreover, we present an efficient method to numerically evaluate the Frechet derivative using its characterization as a boundary value problem and prove fast convergence of this method.
The Influence of Entrainment and Mixing Assumption on Aerosol–Cloud Interactions in Marine Stratocumulus

Abstract This study uses large-eddy simulation with bin microphysics to investigate the influence of entrainment and mixing on aerosol–cloud interactions in the context of idealized, nocturnal, nondrizzling marine stratocumulus (Sc). Of particular interest are (i) an evaporation–entrainment effect and a sedimentation–entrainment effect that result from increasing aerosol concentrations and (ii) the nature of mixing between clear and cloudy air, where homogeneous and extreme inhomogeneous mixing represent the bounding mixing types. Simulations are performed at low resolution (Δz = 20 m; Δx, y = 40 m) and high resolution (Δz = 10 m; Δx, y = 20 m). It is demonstrated that an increase in aerosol from clean conditions (100 cm−3) to polluted conditions (1000 cm−3) produces both an evaporation–entrainment and a sedimentation–entrainment effect, which couple to cause about a 10% decrease in liquid water path (LWP) when all warm microphysical processes are included. These dynamical effects are insensitive to both .
Scaling exponents for turbulent velocity and temperature increments

Measurements in a turbulent wake indicate that, in the inertial range, the power law exponents inferred from the transverse velocity and temperature increments are nearly equal and significantly smaller than the exponents of the longitudinal velocity increment. The relative magnitudes of the exponents for moments up to the eighth order have been determined using the extended self-similarity method.
Two-surgeon, two-center evaluation of a new combined EDOF intraocular lens approach

The combined approach with Mini WELL and Mini WELL PROXA IOLs results in patient's satisfaction, with reported differences between the 2 IOLs in visual acuity, contrast sensitivity, and defocus curve. Purpose: To evaluate visual performance and quality of life after bilateral implantation of 2 extended depth-of-focus intraocular lenses (EDOF IOLs). Setting: Ophthalmology Clinic, Department of Medicine and Science of Ageing, University “G. d'Annunzio” Chieti-Pescara, Italy, and Ophthalmic Unit, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy. Design: Prospective clinical study. Methods: 60 eyes of 30 patients with senile cataract were enrolled in this study. Patients underwent phacoemulsification and bilateral implantation of the Mini WELL IOL in the dominant eye and the Mini WELL PROXA IOL in the nondominant eye within a month. The main outcome measures over a 3-month follow-up period were uncorrected and corrected visual acuity at different distances (33 cm, 60 cm, and 4 m), defocus curve, contrast sensitivity, and patient satisfaction (evaluated by mean of the National Eye Institute Refractive Error Quality-of-Life instrument-42 questionnaire). Results: Binocular uncorrected visual acuity at 90 days was 0.03 ± 0.11 logMAR for long distance, 0.05 ± 0.10 logMAR for intermediate distance, 0.03 ± 0.08 logMAR at 40 cm, and 0.06 ± 0.08 logMAR at 33 cm. Statistically significant differences between the 2 EDOF IOLs in favor of Mini WELL PROXA IOL were observed for uncorrected near visual acuity at 40 and 33 cm (P < .001 and P < .001, respectively) and for distance-corrected near visual acuity at 40 cm (P < .001). Significant differences between the 2 IOLs in the defocus curves were reported. Conclusions: In this small pilot study, bilateral implantation of Mini WELL IOL and Mini WELL PROXA IOL achieved good quantity and quality of vision.