Miracle-dz/UniFAR-FTUs huggingface dataset:
Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study

The present work is a replication article based on the paper “Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies” by McGrath and Stoodley (2019). In the original research, the authors used activation likelihood estimation (ALE), a technique to perform coordinate-based meta-analysis (CBMA), to investigate the existence of brain regions undergoing gray matter alteration in association with both attention-deficit/hyper-activity disorder (ADHD) and dyslexia. Here, the same voxel-based morphometry dataset was analyzed, while using the permutation-subject images version of signed differential mapping (PSI-SDM) in place of ALE. Overall, the replication converged with the original paper in showing a limited overlap between the two conditions. In particular, no significant effect was found for dyslexia, therefore precluding any form of comparison between the two disorders. The possible influences of biological sex, age, and medication status were also ruled out. Our findings are in line with literature about gray matter alteration associated with ADHD and dyslexia, often showing conflicting results. Therefore, although neuropsychological and clinical evidence suggest some convergence between ADHD and dyslexia, more future research is sorely needed to reach a consensus on the neuroimaging domain in terms of patterns of gray matter alteration.
Endoscopic sphincterotomy vs papillary large balloon dilation vs combination modalities for large common bile duct stones: a network meta-analysis

Abstract Background and study aims The optimal technique for removal of large common bile duct (CBD) stones (≥ 10 mm) during endoscopic retrograde cholangiopancreatography (ERCP) remains unclear. We aimed to perform a comparative analysis between different endoscopic techniques. Methods Adhering to PRISMA guidelines, a stringent search of the following databases through January 12, 2021, were undertaken: PubMed/Medline, Embase, Web of Science, and Cochrane. Randomized controlled trials comparing the following endoscopic techniques were included: (1) Endoscopic sphincterotomy (EST); (2) Endoscopic papillary large balloon dilation (EPLBD); and (3) EST plus large balloon dilation (ESLBD). Stone clearance rate (SCR) on index ERCP was the primary outcome/endpoint. Need for mechanical lithotripsy (ML) and adverse events were also evaluated as secondary endpoint. Random effects model and frequentist approach were used for statistical analysis. Results A total of 16 studies with 2545 patients (1009 in EST group, 588 in EPLBD group, and 948 patients in ESLBD group) were included. The SCR was significantly higher in ESLBD compared to EST risk ratio [RR]: 1.11, [confidence interval] CI: 1.00–1.24). Lower need for ML was noted for ESLBD (RR: 0.48, CI: 0.31–0.74) and EPLBD (RR: 0.58, CI: 0.34–0.98) compared to EST. All other outcomes including bleeding, perforation, post-ERCP pancreatitis, stone recurrence, cholecystitis, cholangitis, and mortality did not show significant difference between the three groups. Based on network ranking, ESLBD was superior in terms of SCR as well as lower need for ML and adverse events (AEs). Conclusions Based on network meta-analysis, ESLBD seems to be superior with higher SCR and lower need for ML and AEs for large CBD stones.
Analysis on the Shape Classification of the Head of Korean Female Children for the Headwear Sizing System

This study was aimed to provide the measurement data and shape classification of the head of the Korean female children for the headwear sizing systems. Four hundred nineteen female children, aged nine to twelve years, participated for this study. The 19 regions on the head and height, weight of the subjects were directly measured by the expert experimenters. Factor analysis, cluster analysis, GLM analysis and Tukey HSD test were performed using these data. Through factor analysis, five factors were extracted upon factor scores and those factors comprised for the total variances. Three clusters as their head shape were categorized using fiver factor scores by cluster analysis. Type 1 was characterized by the widest head width, Bitragion arc, and shortest head length, and medium height and weight. Type 2 had the longest head length and the widest side head width and the highest head circumference, and highest height and largest weight. Type 3 was characterized by the medium head length, smallest head circumstance, narrowest head width and side head width, and smallest height and weight.
Effectiveness of a community-based peer support service among persons suffering severe mental illness in China

Background Community-based peer support service is widely and effectively deployed for persons suffering severe mental illness (SMI) in countries with well-developed outpatient mental health systems. The objective of this study is to evaluate the effectiveness of a 1-year peer service project among persons with SMI implemented in China. Methods A total of 101 consumers (service recipients) and 66 family caregivers were recruited at baseline from communities located in Beijing and Chengdu. Severity of psychiatric symptoms, personal and social functioning, self-esteem, life satisfaction, and medication adherence were evaluated among consumers. Self-esteem, life satisfaction, anxiety, and depressive symptoms were assessed among family caregivers. Participants were reevaluated at 1 year with the same measures. Changes in outcomes from baseline to 1-year follow-up were examined using paired sample t tests or Stuart-Maxwell tests. Results Consumers’ psychiatric symptoms were decreased at 1 year (p < 0.001). Their personal and social functioning (p = 0.003) and life satisfaction (p < 0.001) were increased. There were no improvements in self-esteem (p = 0.108) and medication adherence (ps ≥ 0.827) among consumers. For caregivers, no increases were presented in outcomes at the 1-year assessment (ps ≥ 0.164). Conclusions The findings suggest that peer support services could be sustainably implemented across China, with positive impacts on the psychiatric symptoms, social functioning, and life satisfaction of participants suffering SMI.
Association between Physical Fitness, Physical Activity Level and Sense of Coherence in Swedish Adolescents; An Analysis of Age and Sex Differences

Introduction: The aim of this study was to investigate the association between physical fitness, physical activity, and sense of coherence (SOC) in Swedish adolescents (n = 2028 males, n = 1287 females) aged 14 to 18 using a cross-sectional design. Methods: Using the Swedish Physical power Mental harmony and Social capacity (FMS) student profile, participants performed physical tests measuring their cardiovascular ability (CV) and muscular strength. Questionnaires were used to measure physical activity levels (PA), the participation in organized physical training, sedentary behavior (SB), screen time, and SOC value. Multiple linear regression analyses were used to analyze the association between SOC and independent variables. Results: The regression analyses explained a small, shared variance between SOC and the independent variables in boys (4.3%) and girls (3.3%). SB showed a positive association with SOC both in girls (β = 0.114, p = 0.002) and boys (β = 0.109, p = 0.013). Abdominal strength was positively associated, while VO2max was inversely associated, with SOC (β = 0.113, p = 0.022; β = −0.109, p = 0.026, respectively) in boys. Girls had poorer fitness than boys did across all age groups except at age 18. PA levels decreased from age 14 to 18 in girls and boys, but without differences between sexes. Abdominal strength decreased from age 14 to 18 in girls and boys. In general, girls had lower SOC than boys across all age groups. Conclusions: Poor sedentary behavior was significantly associated with weaker SOC for both genders, indicating overall physical activity as the most important factor for stronger SOC. However, emotional support in vulnerable environments may have a bigger impact than physical activity or sedentary behavior on the SOC value for adolescents.
In search of massive single{population Globular Clusters

ABSTRACT The vast majority of globular clusters so far examined shows the chemical signaturesof hosting (at least) two stellar populations. According to recent ideas, this featurerequires a two{step process, in which the nuclearly processed matter from a \ rstgeneration" (FG) of stars gives birth to a \second generation" (SG) bearing the n-gerprint of a fully CNO{cycled matter. Since, as observed, the present population ofmost globular clusters is made up largely of SG stars, a substantial fraction of theFG ( ˘ > 90%) must be lost. Nevertheless, two types of clusters dominated by a sim-ple stellar population (FG clusters) should exist: either clusters initally too small tobe able to retain a cooling ow and form a second generation (FG{only clusters), ormassive clusters that could retain the CNO processed ejecta and form a SG, but wereunable to lose a signi cant fraction of their FG (mainly{FG clusters). Identi cationof mainly{FG clusters may provide an estimate of the fraction of the initial massinvolved in the formation of the SG.We attempt a rst classi cation of FG clusters, based on the morphology of theirhorizontal branches (HBs), as displayed in the published catalogues of photometricdata for 106 clusters. We select, as FG candidates, the clusters in which the HB canbe reproduced by the evolution of an almost unique mass. We nd that less than 20%of clusters with [Fe/H] 30% of SGstars, and its present dynamical status bears less information on its formation processthan the analysis of the chemical abundances of its stars and of its HB morphology.Key words: globular clusters:general; globular clusters:individual: NGC 2419; M 53;Pal 3; stars:abundances
Usability of Social Media for Promoting Higher Learning Institutions’ Activities in Tanzania: A Diffusion of Innovation Perspective

ABSTRACT This study investigates usability of social media in promotion activities among Higher Learning Institutions (HLIs) in Tanzania. Guided by Diffusion of Innovation Perspective, a multi-case study was conducted with four HLIs ranging from public to private offering institutions. Analysis was done using content analysis in line with each research question and the theory of diffusion applied. Findings revealed that social media are perceived the second to traditional media in relative advantage despite being considered easy to use and try. With respect to compatibility, analysis shows the dominance of traditional media whereby social media platforms are not still considered formal and not matching HLIs image. It was also showed that HLIs social media effects are observable through posting college life, upcoming and past events, and publishing new programs. The social media effectiveness included wider reach, receiving questions, feedback, increasing visibility, turnout of people during events and responses to different posts made. The study urges HLIs to actively incorporate social media platforms in the traditional marketing platforms so as to improve their promotions’ effectiveness. Provision of financial and managerial resources is important to make sure their units are active.
Exact gravitational lensing in conformal gravity and Schwarzschild-de Sitter spacetime

An exact solution is obtained for the gravitational bending of light in static, spherically symmetric metrics which includes the Schwarzschild-de Sitter (SdS) spacetime and also the Mannheim-Kazanas (MK) metric of conformal Weyl gravity. From the exact solution, we obtain a small bending-angle approximation for a lens system where the source, lens and observer are co-aligned. This expansion improves previous calculations where we systematically avoid parameter ranges which correspond to non-existent null trajectories. The linear coefficient γ characteristic to conformal gravity is shown to contribute enhanced deflection compared to the angle predicted by General Relativity for small γ.
Stochastic Stability in Games with Alternative Best Replies

Abstract We investigate an evolutionary process that is continually perturbed by "mutations. " If the support of the (unique) stochastically stable distribution is a singleton, then it must be a Nash equilibrium. If one element of a "mutation-connected component" of Nash equilibria appears in the stochastically stable distribution, then all members of that component appear. This implies that the stochastically stable distribution will include weakly dominated strategies in many cases, and in some cases the outcome may include only weakly dominated strategies. Choice trembles can eliminate weakly dominated strategies if but only if they occur with arbitrarily higher probability than that of mutations. Journal of Economic Literature Classification Numbers: C70, C72.
AVA-NP-695 Selectively Inhibits ENPP1 to Activate STING Pathway and Abrogate Tumor Metastasis in 4T1 Breast Cancer Syngeneic Mouse Model

Cyclic GMP-AMP synthase (cGAS) is an endogenous DNA sensor that synthesizes cyclic guanosine monophosphate–adenosine monophosphate (2′3′-cGAMP) from ATP and GTP. 2′3′-cGAMP activates the stimulator of interferon genes (STING) pathway, resulting in the production of interferons and pro-inflammatory cytokines. Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the phosphodiesterase that negatively regulates the STING pathway by hydrolyzing 2′3′-cGAMP. It has been established that the cGAS–STING pathway plays a major role in inhibiting tumor growth by upregulating T cell response. Herein, we demonstrate that AVA-NP-695, a selective and highly potent ENPP1 inhibitor, apart from the immunomodulatory effect also modulates cancer metastasis by negatively regulating epithelial–mesenchymal transition (EMT). We established that the combined addition of 2′3′-cGAMP and AVA-NP-695 significantly abrogated the transforming growth factor beta (TGF-ꞵ)-induced EMT in MDA-MB-231 cells. Finally, results from the in vivo study showed superior tumor growth inhibition and impact on tumor metastasis of AVA-NP-695 compared to Olaparib and PD-1 in a syngeneic 4T1 breast cancer mouse model. The translation of efficacy from in vitro to in vivo 4T1 tumor model provides a strong rationale for the therapeutic potential of AVA-NP-695 against triple-negative breast cancer (TNBC) as an immunomodulatory and anti-metastatic agent.
Revisiting a Macroeconomic Controversy: The Case of the Multiplier–Accelerator Effect

This paper presents the bibliometrics of a Keynesian and neoclassical discussion about the multiplier–accelerator effect. Having its oldest roots in the 1930s, there was a special emphasis in the 1960s and 1970s on discussions regarding the dependence of current investment on economic growth (the accelerator effect). Through a bibliometric analysis, we also consider the Hicks–Samuelson contribution, also known as the multiplier–accelerator model. We identified, among other things, the most relevant authors on the topics, the economic areas that have been contributed to the most through keyword analysis, and the most notable contributions through citation analysis. We concluded that several areas in economics have taken advantage of the discussion around the multiplier–accelerator effect, especially the discussion on the business cycle, structural dynamics, and public finance.
Investigation and Analysis of Pesticide Residues in Four Common Vegetables and Risk Assessment of Dietary Exposure in Ceramic Capital, China

In order to understand the basic situation of pesticide residues in vegetables in China’s porcelain capital, four kinds of common vegetables on the market were selected in this study for detection and analysis of pesticide residues. The pesticide residues in vegetables were analyzed through sample selection, optimization of instrument and equipment conditions, and comparison of detection pass rates. The sampling locations were common vegetables purchasing places such as large and medium-sized supermarkets. QuEChERS method was used as the sample pretreatment, and gas chromatography (GC-MS/MS) was used for quantitative analysis. Finally, the exposure risk of pesticides was assessed according to the test results. The results showed that all the pesticides were detected in four kinds of vegetables, but the detected pesticides did not exceed the national standard (GB 2763-2014, China). Moreover, the target risk coefficient (THQ) and risk index (HI) values of four vegetables were less than one, indicating that the combined and toxic effect of pesticide residual mixed contamination was smaller in four vegetables. Therefore, there was no significant harm from people using these vegetables.
BLACK HOLE POWERED NEBULAE AND A CASE STUDY OF THE ULTRALUMINOUS X-RAY SOURCE IC 342 X-1

We present new radio, optical, and X-ray observations of three ultraluminous X-ray sources (ULXs) that are associated with large-scale nebulae. We report the discovery of a radio nebula associated with the ULX IC 342 X-1 using the Very Large Array (VLA). Complementary VLA observations of the nebula around Holmberg II X-1, and high-frequency Australia Telescope Compact Array and Very Large Telescope spectroscopic observations of NGC 5408 X-1 are also presented. We study the morphology, ionization processes, and the energetics of the optical/radio nebulae of IC 342 X-1, Holmberg II X-1, and NGC 5408 X-1. The energetics of the optical nebula of IC 342 X-1 is discussed in the framework of standard bubble theory. The total energy content of the optical nebula is 6 × 1052 erg. The minimum energy needed to supply the associated radio nebula is 9.2 × 1050 erg. In addition, we detected an unresolved radio source at the location of IC 342 X-1 at the VLA scales. However, our Very Long Baseline Interferometry (VLBI) observations using the European VLBI Network likely rule out the presence of any compact radio source at milliarcsecond (mas) scales. Using a simultaneous Swift X-ray Telescope measurement, we estimate an upper limit on the mass of the black hole in IC 342 X-1 using the “fundamental plane” of accreting black holes and obtain MBH ⩽ (1.0 ± 0.3) × 103 M☉. Arguing that the nebula of IC 342 X-1 is possibly inflated by a jet, we estimate accretion rates and efficiencies for the jet of IC 342 X-1 and compare with sources like S26, SS433, and IC 10 X-1.
FIRST MEASUREMENTS OF 15N FRACTIONATION IN N2H+ TOWARD HIGH-MASS STAR-FORMING CORES

We report on the first measurements of the isotopic ratio 14N/15N in N2H+ toward a statistically significant sample of high-mass star-forming cores. The sources belong to the three main evolutionary categories of the high-mass star formation process: high-mass starless cores, high-mass protostellar objects, and ultracompact H ii regions. Simultaneous measurements of the 14N/15N ratio in CN have been made. The 14N/15N ratios derived from N2H+ show a large spread (from ∼180 up to ∼1300), while those derived from CN are in between the value measured in the terrestrial atmosphere (∼270) and that of the proto-solar nebula (∼440) for the large majority of the sources within the errors. However, this different spread might be due to the fact that the sources detected in the N2H+ isotopologues are more than those detected in the CN ones. The 14N/15N ratio does not change significantly with the source evolutionary stage, which indicates that time seems to be irrelevant for the fractionation of nitrogen. We also find a possible anticorrelation between the 14N/15N (as derived from N2H+) and the H/D isotopic ratios. This suggests that 15N enrichment could not be linked to the parameters that cause D enrichment, in agreement with the prediction by recent chemical models. These models, however, are not able to reproduce the observed large spread in 14N/15N, pointing out that some important routes of nitrogen fractionation could be still missing in the models.
Binaural masking of amplitude modulation

A new concept concerned with the transformation of acoustic stimuli in the auditory system postulates the existence of a form of spectral analysis applied to the amplitude changes of the stimuli. It is assumed that this analysis takes place in the so-called modulation filters, i.e. bandpass linear filters tuned to different rates of the amplitude changes. The most striking argument supporting this idea is an effect of masking in the amplitude modulation domain whose nature can be easily explained basing on this concept. As the modulation filters are situated on the higher levels of the auditory system, it is also assumed that this form of masking is entirely a central process. However, most of the studies concerned with masking in the modulation domain used monaural listening only. Therefore, the main purpose of the presented here experiments was to investigate whether this type of masking is entirely a central process. Using a Three-Alternative Forced-Choice (3AFC) procedure the binaural and monaural masked thresholds of amplitude modulation were determined. A sinusoidal carrier at a frequency of 4 kHz was amplitude modulated by a specially designed band of noise characterized by a very low value of the crest factor, which was used as a masking signals. Different bandwidths of the modulating masking signals were used as well as different center frequencies to investigate whether the masking patterns in the modulation domain depend on the masker bandwidth and its center frequency. The modulating target (masked) signal was a pure tone at a frequency range from 2 to 256 Hz. Both modulating signals were applied to the same sinusoidal carrier signal. The most effective masking was noticed when the rate of the sinusoidal modulation was close to the center frequency of the masking signal or when it was in its spectral range and decreased outside of this range. The character of this dependence confirms the existence of some form of a frequency selectivity in the modulation rate domain similarly to the audible frequency domain. The thresholds for monaural and binaural listening were very close to each other. This implies that masking in the modulation domain is a central process.
Targeting Epigenetic Regulation of Cardiomyocytes through Development for Therapeutic Cardiac Regeneration after Heart Failure

Cardiovascular diseases are the leading cause of death globally, with no cure currently. Therefore, there is a dire need to further understand the mechanisms that arise during heart failure. Notoriously, the adult mammalian heart has a very limited ability to regenerate its functional cardiac cells, cardiomyocytes, after injury. However, the neonatal mammalian heart has a window of regeneration that allows for the repair and renewal of cardiomyocytes after injury. This specific timeline has been of interest in the field of cardiovascular and regenerative biology as a potential target for adult cardiomyocyte repair. Recently, many of the neonatal cardiomyocyte regeneration mechanisms have been associated with epigenetic regulation within the heart. This review summarizes the current and most promising epigenetic mechanisms in neonatal cardiomyocyte regeneration, with a specific emphasis on the potential for targeting these mechanisms in adult cardiac models for repair after injury.