Miracle-dz/UniFAR-FTUs huggingface dataset:
Keterampilan Motorik Kasar Anak Usia Prasekolah di TK Muslimat NU Dewi Masithoh 01 Kalipare Kabupaten Malang

Abstract: Gross motor skills are a very important aspect in the growth process of preschool age children because gross motor skills will have an impact on children's development in the future. This study aims to determine the gross motor skills of preschool-aged children in TK Muslimat NU Dewi Masithoh 01 Kalipare, Malang Regency. This research is a non-experimental research that uses a survey approach method with a quantitative descriptive research design. The research instrument used to identify the level of gross motor skills of children is the Test of Gross Motor Development-2 (TGMD-2). The final result of this study showed that the gross motor skills of preschool children in TK Muslimat NU Dewi Masithoh 01 Kalipare Malang Regency showed an average gross motor score of 110.84 with an average category. The conclusion of this study is that in general the gross motor skills of preschool-aged children in TK Muslimat NU Dewi Masithoh 01 Kalipare Malang are included in the average category in terms of two measuring indicators, namely locomotor motion and manipulative motion, so that it can be said that gross motor skills are still in progress. developmental stage. Abstrak: Keterampilan motorik kasar merupakan sebuah aspek yang sangat penting dalam proses tumbuh kembang anak usia prasekolah karena keterampilan motorik kasar akan berdampak pada perkembangan anak di masa depan. Penelitian ini bertujuan untuk mengetahui keterampilan motorik kasar anak usia prasekolah di TK Muslimat NU Dewi Masithoh 01 Kalipare Kabupaten Malang. Penelitian ini merupakan penelitian non-eksperimen yang menggunakan metode pendekatan survei dengan rancangan penelitian deskriptif kuantitatif. Instrumen penelitian ini yang digunakan untuk mengidentifikasi tingkat keterampilan motorik kasar anak adalah Test of Gross Motor Development-2 (TGMD-2). Hasil akhir dari penelitian ini menunjukkan bahwa keterampilan motorik kasar anak prasekolah di TK Muslimat NU Dewi Masithoh 01 Kalipare Kabupaten Malang menunjukkan nilai rerata skor motorik kasar 110.84 dengan kategori rata-rata. Kesimpulan dari penelitian ini adalah secara umum keterampilan motorik kasar anak usia prasekolah di TK Muslimat NU Dewi Masithoh 01 Kalipare Malang termasuk ke dalam kategori rata-rata yang ditinjau dari dua indikator ukur yaitu gerak lokomotor dan gerak manipulatif, sehingga dapat dikatakan keterampilan motorik kasar masih dalam tahap perkembangan.
The Implication of Topoisomerase II Inhibitors in Synthetic Lethality for Cancer Therapy

DNA topoisomerase II (Top2) is essential for all eukaryotic cells in the regulation of DNA topology through the generation of temporary double-strand breaks. Cancer cells acquire enhanced Top2 functions to cope with the stress generated by transcription and DNA replication during rapid cell division since cancer driver genes such as Myc and EZH2 hijack Top2 in order to realize their oncogenic transcriptomes for cell growth and tumor progression. Inhibitors of Top2 are therefore designed to target Top2 to trap it on DNA, subsequently causing protein-linked DNA breaks, a halt to the cell cycle, and ultimately cell death. Despite the effectiveness of these inhibitors, cancer cells can develop resistance to them, thereby limiting their therapeutic utility. To maximize the therapeutic potential of Top2 inhibitors, combination therapies to co-target Top2 with DNA damage repair (DDR) machinery and oncogenic pathways have been proposed to induce synthetic lethality for more thorough tumor suppression. In this review, we will discuss the mode of action of Top2 inhibitors and their potential applications in cancer treatments.
Maximum likelihood theory for large interacting systems

The problem of estimation of parameters from a system of N interacting particles described by Ito stochastic differential equations is studied. It is shown that the maximum likelihood estimator is consistent and asymptotically normal in the limit $N \to \infty $. The particular case of a mean-field-type model of exchangeable and interacting diffusions is treated in greater detail. Finally, an application to the testing of hypothesis of noninteraction is briefly discussed.
Psychological well-being among Gen Z social media users: Exploring the role of self-esteem and social media dependency as mediators and social media usage motives as moderator

Social media has become an inseparable part of Gen Z’s life. However, a number of previous research documented contradictive findings regarding social media use and its effect on psychological wellbeing among adolescents. This study aimed to investigate the role of self-esteem, social media dependency, and motives of social media use in the psychological well-being of Gen Z adolescents. A total of 647 students (aged 12 to 21 years, comprising 282 males and 365 females) participated and completed several self-reported instruments, including the Rosenberg Self-Esteem Scale (RSES), the Online Social Network Dependency Scale (OSNDS), the Social Media Usage Motives Scale (SMUMS), and the Mental Health Inventory (MHI-18). Results from Structural Equation Modelling (SEM) showed that self-esteem was a positive predictor, while social media dependency was a negative predictor of psychological well-being in Gen Z adolescents. Social media dependency was also found significantly mediate the link between self-esteem and psychological well-being. In addition, motives for social media use were a significant moderator of the relationship between social media dependency and psychological well-being, in which a maintaining existing relationship motive intensified this association, while a meet new people and socializing motive weakened it. These findings implied the importance of an intervention targeting selfesteem in understanding the motive behind adolescents’ use of social media so that their consumption of social media could be appropriate and offer benefits for their psychological well-being.
Sequential Release of Panax Notoginseng Saponins and Osteopractic Total Flavone from Poly (L-Lactic Acid) Scaffold for Treating Glucocorticoid-Associated Osteonecrosis of Femoral Head

Glucocorticoids inhibit angiogenesis in the femoral head, which fails to nourish the bone tissue and leads to osteonecrosis. Restoring angiogenesis is not only essential for vessel formation, but also crucial for osteogenesis. Poly (L-lactic acid) (PLLA) is commonly used in the bone tissue engineering field. Panax notoginseng saponins (PNS) and osteopractic total flavone (OTF) promote angiogenesis and osteogenesis, respectively. We designed a sequentially releasing PLLA scaffold including PLLA loaded with OTF (inner layer) and PLLA loaded with PNS (outer layer). We assessed the osteogenic effect of angiogenesis in this scaffold by comparing it with the one-layered scaffold (PLLA embedded with OTF and PNS) in vivo. Results from the micro-CT showed that the data of bone mineral density (BMD), bone volume (BV), and percent bone volume (BV/TV) in the PO-PP group were significantly higher than those in the POP group (p < 0.01). Histological analyses show that the PO-PP scaffold exhibits better angiogenic and osteogenic effects compared with the one-layered scaffold. These might result from the different structures between them, where the sequential release of a bi-layer scaffold achieves the osteogenic effect of vascularization by initially releasing PNS in the outer layer. We further explored the possible mechanism by an immunohistochemistry analysis and an immunofluorescence assay. The results showed that the protein expressions of vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1(CD31) in the PO-PP scaffold were significantly higher than those in the POP scaffold (p < 0.01); the protein expressions of osteocalcin (OCN), osteopontin (OPN), and alkaline phosphatase (ALP) in the PO-PP scaffold were significantly higher than those in the POP scaffold (p < 0.05). Upregulating the expressions of angiogenic and osteogenic proteins might be the possible mechanism.
A Comparison of Social Exclusion Towards People with Depression or Chronic Back Pain

Objectives Research comparing mental and physical health stigma is scarce. The aim of this study was to compare social exclusion towards hypothetical males and females with depression or chronic back pain. Furthermore, the study investigated whether social exclusion is associated with participant’s empathy and personality traits, while controlling for their sex, age and personal exposure to mental/physical chronic health conditions. Design This study employed a cross-sectional questionnaire design. Methods Participants (N = 253) completed an online vignette-based questionnaire and were randomly allocated to either a depression or chronic back pain study condition. Measures of social exclusion through respondents’ willingness to interact with hypothetical individuals, empathy and the Big Five personality traits were completed. Results Willingness to interact scores did not significantly differ depending on the diagnosis or sex of the hypothetical person in the vignette. For depression, higher levels of conscientiousness significantly predicted less willingness to interact. Whilst being a female participant and having higher empathy significantly predicted greater willingness to interact. For chronic back pain, higher empathy significantly predicted greater willingness to interact, with no significant predictors found from the Big Five personality traits. Conclusion Findings indicate that females and males with depression or chronic back pain face similar levels of social exclusion, with empathy being a core variable driving social exclusion behaviours. These findings enhance our understanding of potential variables driving social exclusion, in-turn informing campaign development to reduce public stigma towards depression and chronic back pain.
Acoustic and aerodynamic correlates of Hindi stops

In order to find out how the four Hindi stop types, p, ph, b, bh, are produced, we obtained the following data from native speakers: averaged fundamental frequency (FO) contours (on either side of the stops), oral air flow, and lung volume (via a plethysmograph) during the production of the stops in a sentence frame. The results include the following: (1) although the breathy‐voiced stops lower FO a great deal on the vowels following them, there is no consistent effect on FO by the other stop types, assuming the comparison of the various FO contours is done with respect to consonant onset, (2) the plethysmographic data reveal that short‐term variations in lung volume are purely a passive reaction to the rate of air flow out of the lungs—in other words, in contrast to previous claims, there is no active participation of the pulmonic system in the production of aspirated stops. [Supported by NSF. ]
De/centralization in Mexico, 1824–2020

ABSTRACT This article presents an analysis of de/centralization in Mexico during the period 1824–2020, building on an original dataset that coded three subdimension of the politico–institutional arrangement, 22 policy areas and 5 subdimension of the fiscal sphere for each year during that time. The country evolved from a decentralized federation at the outset to a relatively centralized one nowadays. The Mexican case also sheds light on the importance of regime type and the ruling elite's ideological orientation to explain de/centralization patterns. Centralization was prevalent during two long authoritarian periods since the last quarter of the XIX century. On the contrary, dynamic decentralization occurred once the authoritarian regime began to erode in the 1980s. The ideological orientation of the ruling elite helped to strengthen those trajectories. When that elite embraced developmental ideas, the move towards centralization was deeper, whereas the opposite took place once national authorities embraced a neoliberal agenda.
Acoustic axes for elastic waves in crystals: theory and applications

The purpose of this paper is to present a simple and direct way of finding the number of acoustic axes and their locations for all crystals of orthorhombic, tetragonal, hexagonal or cubic symmetry (‘RTHC crystals’). The procedure is based upon a decomposition of the acoustical tensor due to Fedorov and Fedorov. Excepting cases for which there may be an infinity of acoustic axes (for instance, the case of hexagonal crystals), it is shown that RTHC crystals may have at most sixteen acoustic axes, four in each coordinate plane, and four out of coordinate planes. Very simple equations are presented for the explicit determination of these acoustic axes. Then, these results are applied in turn to each of the RTHC crystal systems. In each case the possible numbers of acoustic axes are easily obtained. Explicit numerical examples are presented for several specific crystals.
Benders' cuts guided large neighborhood search for the traveling umpire problem

This article introduces the use of Benders' cuts to guide a large neighborhood search to solve the traveling umpire problem, a sports scheduling problem inspired by the real‐life needs of the officials of a sports league. At each time slot, a greedy matching heuristic is used to construct a schedule. When an infeasibility is recognized first a single step backtracking is tried to resolve the infeasibility. If unsuccessful, Benders' cuts are generated to guide a large neighborhood search to ensure feasibility and to improve the solution. Realizing the inherent symmetry present in the problem, a large family of cuts are generated and their effectiveness is tested. The resulting approach is able to find better solutions to many instances of this problem. © 2011 Wiley Periodicals, Inc. Naval Research Logistics, 2011
The meta-analysis study of SAVI learning model on student’s cognitive aspects in biology learning

The meta-analysis study for currently do not have the latest research on the SAVI learning model on student’s cognitive aspect in learning biology, especially about education level, region, and the dependent variable. This research aims to analyze the effectiveness of apllication of the SAVI learning model on student’s cognitive aspects in Biology learning. The method used is meta-analysis, that is the analysis that present the results of publication scientific research in electronic journal nationally concern the influence of the SAVI learning model on student’s cognitive aspect. The sample used was 14 articles from 35 scientific articles published in accredited national journals, after filtering the articles. The instrument used is in the form of a category coding sheet for articles. The results showed that the overall results of SAVI learning model were able to improve the cognitive abilities of student in the experimental group with an effect size of 0.2246. Based on the education level at the elementary, junior, and senior high school levels with the effect size category, respectively obtained 0.2282, 0.1196, and 0.6162. Based on the region, the effect size in each region was obtained that is in Central Java 0.1389; East Java 0.2460; West Java 0.0394; Bali 0.3069; South Sumatra 0.0242, and 0.3057 in Southeast Sulawesi. Based on the research dependent variable with the results were obtained problem solving skill 0.0742; achievement 0.2916; critical thinking 0.1086; communication skill 0.0242; and reasoning ability 0.3057.
Generalized q-bosons and their squeezed states

Generalized q-boson operators associated with the simultaneous creation of several q-bosons are introduced. These operators give rise to a realization of the quantum Weyl-Heisenberg algebra and are applied to the construction of corresponding Holstein-Primakoff realizations of the quantum algebras SUq(2) and SUq(1,1). Coherent states of these algebras are defined in the various ways suggested by the equivalent definitions of the harmonic oscillator coherent states, and some of their properties are studied. Particular attention is devoted to the squeezing properties of the quadrature of the electromagnetic field in these states.
Experimental study on properties and structure of magnesium alloy/PC/ABS hybrid materials prepared by hot-press molding technology

Abstract Magnesium alloy/PC/ABS composites were prepared by hot-press molding technology. The bonding strength is the crucial factor to influence the comprehensive performance of this composite, and it was closely related to the different processing parameters such as temperature, pressure and time. After exploring their relationship, the optimal hot-press processing condition was obtained. The micro- and nano-structure of composites also received attention. Before hot-pressed, the magnesium alloy surface was treated by micro-arc oxidation in order to construct the nano-sized pores. With the aid of scanning electron microscope (SEM) and atomic force microscope (AFM), a refined mechanical interlocking structure was observed with the formation of coordinate bonds at the interface of an alloy-polymer hybrid. The binding energy of the chemical elements at the bonding interface of the composite was also tested by X-ray photoelectron spectroscopy (XPS) and the analysis concluded that coordination bonds were formed at the bonding interface. The maximum tensile shear strength of the composite reached 9.48 MPa.
Distributed extremum‐seeking based resource allocation algorithm with input dead‐zone

This paper studies distributed resource allocation problem for agents with input dead‐zone, which is not considered in the existing work. At first, the primal problem is transformed to an auxiliary problem by using the exact penalty method to deal with local inequality constraints. It is assumed that the explicit expressions of cost functions and local inequality constraints are unknown to agents but the values of the cost and constraint functions can be obtained. Under such a setup, the extremum seeking control is used to estimate the gradient information. Thus, to obtain the optimal allocation, a novel distributed algorithm is designed by the virtue of the extremum seeking control and a dynamic compensating mechanism which is used to handle the effects of the input dead‐zone. Due to a two time‐scale structure of the designed distributed algorithm, the semi‐globally practically asymptotical convergence of all agents' decisions to the optimal allocation is obtained by the singular perturbation technique. Finally, numerical examples of economic dispatch in smart grids are given to verify the effectiveness of our proposed method.
Polymer conformations and hysteretic stresses in nonstationary flows of polymer solutions

The low Reynolds number flow of a polymer solution around a cylinder engenders a nonlinear drag force vs. the flow velocity. A velocity quench of such a flow gives rise to a long time relaxation and hysteresis of the stress due to history-dependent elastic effects. Our results suggest that such hysteretic behavior has its origin in the long time relaxation dynamics and hysteresis of the polymer conformations.
Wolbachia infected and uninfected mosquito growth model using the Leslie multispecies matrix model

: Currently, there is a new strategy for stopping the spread of dengue, namely infecting wild mosquitoes with Wolbachia bacteria. Wolbachia is a bacteria that can lower the rate of infection in a mosquito's body, which lowers the risk of the virus being transmitted when it bites susceptible people. Our aim in this paper is to find the equilibrium points and perform local stability analysis for each equilibrium point of a growth model of uninfected and Wolbachia-infected Aedes aegypti mosquitoes. The growth model of the two types of mosquitoes was modeled using the Leslie multispecies matrix model. We assume that the first species is Wolbachia-uninfected mosquitoes and the second species is Wolbachia-infected mosquitoes. In this study, we obtained four equilibrium points. Then, we obtain asymptotically local stability conditions at the four equilibrium points. Based on these results, this study provides conditions that guarantee that efforts to use Wolbachia can suppress dengue disease
Abundances in galactic H2 regions, 3: G25.4-0.2, G45.5+0.06, M8, S159 and DR22

Measurements of the ARII (6.99 microns), ArIII (8.99 microns), NeII (12.81 microns), SIII (18.71 microns), and SIV (10.51 microns) lines are presented for five compact HII regions along with continuum spectroscopy. From these data and radio data, lower limits to the elemental abundances of Ar, S, and Ne were deduced. The complex G25.4-0.2 is only 5.5 kpc from the galactic center, and is considerably overabundant in all these elements. Complex G45.5+0.06 is at seven kpc from the galactic center, and appears to be approximately consistent with solar abundance. The complex S159 in the Perseus Arm, at 12 kpc from the galactic center, has solar abundance, while M8 in the solar neighborhood may be somewhat overabundant in Ar and Ne. Complex DR 22, at 10 kpc from the galactic center in the Cygnus Arm, is overabundant in Ar. A summary of results from a series of papers on abundances is given.
On the evolution and breakup of slender drops in an extensional flow

The evolution of the shape of an elongated drop embedded in an extensional flow is studied in the framework of slender body theory. The external flow has a weak but not neglected inertia. The problem is governed by three dimensionless parameters: the capillary number, the external Reynolds number, and the viscosity ratio between the drop and the external fluid, and exhibits a multiplicity of stationary shapes with only one being stable. Evolution of the drop surface from initial shapes was studied when the flow intensity was either kept constant or subjected to a sudden change. It was shown that the dynamics of the shape evolution can lead to a breakup of the drop or to a stable stationary shape. Two modes of breakup are revealed: an indefinite elongation and a center pinching mode. The former appears when the viscous forces dominate the inertia effects, with the typical case being that of a creeping flow. The latter breakup mode takes over in the presence of inertia when the drop viscosity diminishes wit.
Body Composition in Karate: A Dual-Energy X-ray Absorptiometry Study

Karate is a widely practiced combat sport. Karatekas’ body composition has typically been obtained in small groups using skinfolds or bioelectric impedance. In this work, we assessed three-compartment body composition using the accurate dual-energy X-ray absorptiometry technique (QDR Horizon, Hologic) in a large sample (n = 58; 74% males) of black belt karatekas. Stature-adjusted body composition indices (fat mass index; fat-free mass index; bone mineral apparent density) were calculated. The Student’s t-test was used for group–group analysis. Correlation was assessed using the Pearson’s r. The ability of fat-free soft tissue mass to predict bone mineral content and areal bone mineral density was assessed with linear regression. Reference mean and quartile values for whole-body and regional body composition were obtained for the male athletes. The body composition indices were generally more favorable in the male than female karatekas. The bone mineral apparent density was similar in the males and females at all sites except the right leg. The fat-free soft tissue mass predicted the bone mineral content and areal bone mineral density with good accuracy (R2 = 0.542–0.827; p < 0.001 for all models). The data presented in this paper are expected to be of use for karate coaches, physical trainers, and participants interested in assessing and monitoring athletes’ body composition.