Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impacts of Tinea Capitis on Quality of Life: A Community Based Cross Sectional Study among Nigerian Children

Despite the untold prevalence of tinea capitis (TC) among children in the developing countries, no single study has examined its impacts on children’s quality of life (QoL). The focus of the present study is to examine the impacts of TC on QoL and to identify the patients and disease variables that affect QoL as determined by the Children’s Dermatology Life Quality Index (CDLQI). A multistage probability random sampling was conducted among predominantly Yoruban children. A total of 370 children, 185 children with TC and 185 without TC, were recruited as subjects and controls. The CDLQI test instrument was translated and validated in a pilot study before use. Diagnosis of TC was done through microscopy and CDLQI questionnaire was administered to both subjects and controls. A total of 131 (70.8%) boys and 54 (29.2%) girls with TC were included as subjects, with the mean age of 7.31 ± 2.52 years. There was no significant difference between the ages of the subjects and controls (P = 0.67). The children with TC had significantly higher mean CDLQI score than the control, 7.17 ± 3.034 versus 0.00 ± 0.000 respectively (t = 32.132, P , 0.001). The physician assessed severity was identified as a significant factor by the mean of total CDLQI, with an Eigenvalue of 3.57 (canonical correlation, r = 0.88; χ2 = 276.265; df = 2; P , 0.001). Symptom/feeling and treatment subscales were mostly impaired. Symptoms such as itching, alopecia, adenopathy, and difficulties due to treatment contributed most significantly to QoL impairment (P , 0.01). TC onset after age 5 years, teenage presence, level of education, atopy history and clinical type of TC were important factors which negatively affect QoL. In this we identified the patient and disease variables that negatively affect QoL among children with TC.
Estimating the Dynamics of Individual Opinions in Online Communities

How do opinions change as a result of public interactions and exchange of ideas? How does the proliferation of online media influence these dynamics? While theoretical research provides several hypotheses, empirical analysis of opinion dynamics in online communities is lagging. We develop a unique method for quantifying users’ opinions in a social news website and estimate the decision rules that regulate website visit, story posting, voting, and opinion change. We find evidence for significant and nonlinear opinion change as a result of exposure to near-opinions. We also find evidence of learning as people adjust their activity based on the feedback they receive online and strategic reciprocal voting. Incorporating these decision rules in a simulation model we show the propensity of this online community to converge to the majority opinion, and discuss the underlying mechanisms and implications.
EXTENDED USE OF TECHNOLOGY AND STUDENTS' THEORIES ABOUT WRITING

Writers build theories about writing which they test and reconstruct (Dyson, 1989). The theories about writing held by the individual writer influence writing outcomes. If a writer believes that print is fixed or that form is more important than content, as Graves (1983) implies many children do, then such a writer may not readily rework a piece or, if they do, may revise at a surface level, attending to neatness or spelling.
Does nitrogen deposition increase forest production

Effects of elevated N deposition on forest aboveground biomass were evaluated using longterm data from N addition experiments and from forest observation plots in Switzerland. N addition experiments with saplings were established both on calcareous and on acidic soils, in 3 plots with Fagus sylvatica and in 4 plots with Picea abies. The treatments were conducted during 15 years and consisted of additions of dry NH4NO3 at rates of 0, 10, 20, 40, 80, and 160 kg N ha yr. The same tree species were observed in permanent forest observation plots covering the timespan between 1984 and 2007, at modelled N deposition rates of 12-46 kg N ha yr. Experimental N addition resulted in either no change or in a decreased shoot growth and in a reduced phosphorus concentration in the foliage in all experimental plots. In the forest, a decrease of foliar P concentration was observed between 1984 and 2007, resulting in insufficient concentrations in 71% and 67% of the Fagus and Picea plots, respectively, and in an increasing N:P ratio in Fagus. Stem increment decreased during the observation period even if corrected for age. Forest observations suggest an increasing P limitation in Swiss forests especially in Fagus which is accompanied by a growth decrease whereas the N addition experiments support the hypothesis that elevated N deposition is an important cause for this development. Capsule: Low P levels limit growth in Swiss forests
CMAR_A_203156 4743..4756

1Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People’s Republic of China; 2Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People’s Republic of China; 3Heilongjiang Cancer Research and Prevention Institute, Harbin, Heilongjiang, People’s Republic of China; 4Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China; 5Medical Imaging Center, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People’s Republic of China
Columban Simulation Project 2.0: Numerical Competence and Orthographic Processing in Pigeons and Primates

Thirty years ago Burrhus Frederic Skinner and Robert Epstein began what is known as the Columban Simulation Project. With pigeons as their subjects, they simulated a series of studies that purportedly demonstrated insight, self-recognition, and symbolic communication in chimpanzees. In each case, with the appropriate training, they demonstrated that pigeons performed in a comparable manner to chimpanzees. When discussing these studies in the context of his Null Hypothesis, Macphail paid little attention to how the pigeons and chimpanzees solved the tasks and simply assumed that successful performance on the tasks reflected a similar underlying mechanism. Here, following a similar process to the original Columban Simulation Project, we go beyond this success testing and employ the signature testing approach to assess whether pigeons and primates employ a similar mechanism on tasks that tap numerical competence and orthographic processing. Consistent with the Null Hypothesis, pigeons and primates successfully passed novel transfer tests and, critically, displayed comparable cognitive signatures. While these findings demonstrate the absence of a qualitative difference, the time taken to train pigeons on these tasks revealed a clear quantitative difference.
Body Size Judgments at 17 ms: Evidence From Perceptual and Attitudinal Body Image Indexes

Evidence related to temporal control for stimuli presentation of whole-body image is generally associated with attentional bias to ideal thin bodies. Few studies present evidence concerning whole-body stimuli recognition during fast visual exposure intervals. The aim of this study was to evaluate the accuracy and reaction times for the judgment of different sized body silhouettes presented at 17 ms in a non-clinical sample. Thirty-one participants were divided in attitudinal and perceptual body image groups based on Figure Rating Scale output and performed two experiments. First experiment assessed perception and the clarity of visual experience for human and non-human body stimuli at 17 ms. A general accuracy of 69.17% was registered with no differences between perceptual and attitudinal body image groups. These results indicated that the way participants perceive their own bodies does not influence the recognition of general visual silhouette stimuli. It was also observed that the clarity of visual experience is positively correlated to stimuli recognition accuracy. In the second experiment participants had to respond in a seven-point Likert scale if the presented image of body silhouettes were bigger, equal or thinner than their own bodies. Trials were divided in two blocks based on spatial rotation, half at 0° and half at 180°. General accuracy for body silhouettes recognition was 41.1%. Greater accuracy recognition for regular positioned stimuli was observed. Attitudinal dimension of body image was not a predictor of differential performance whereas perceptual body image groups recorded contrasting recognition performance. Distorted body image participants presented higher accuracy than undistorted body image participants, with greater accuracy to thinner silhouette figures. Women had significantly higher overall accuracy than men considering both experimental blocks. When comparing the cumulative accuracy curves across experimental trials, an exposure effect was registered only for the first experiment. Results showed that body silhouette stimuli were judged in a fast exposure interval with differential accuracy rates only for perceptual body image groups. Such evidence signals that conscious body image can be associated to implicit detection of visual human body stimuli. Future studies should further test how traditional explicit body image outputs perform within experimental approaches.
Treatment of chronic noncancer pain in patients on opioid therapy in primary care: A retrospective cohort study

Background: This study sought to characterize the real-world treatment of chronic noncancer pain (CNCP) in patients on opioid therapy in primary care. Methods: A retrospective cohort study from 2014-18 was conducted at a multidisciplinary primary care clinic in Chilliwack, British Columbia. Included were adults on daily opioid therapy for CNCP. Patients receiving palliative care or ≤1 visit were excluded. Outcomes of interest included use of opioid/nonopioid pharmacotherapy, number/frequency of visits and proportion of patients able to reduce/discontinue opioid therapy. Results: Seventy patients (mean age 53 years, 53% male, 51% back pain) were included. Median follow-up was 6 visits over 12 months. Sixty-two patients (89%) reduced their opioid dose, 6 patients had no change and 2 patients required a dose increase. Mean opioid dose was reduced from 183 to 70 mg morphine equivalents daily. Twenty-four patients (34%) discontinued opioid therapy, 6 patients (9%) transitioned to opioid agonist therapy and 6 patients (9%) breached their opioid treatment agreement. Nonopioid pharmacotherapy included nonsteroidal anti-inflammatory drugs (64%), gabapentinoids (63%), tricyclic antidepressants (56%) and nabilone (51%). Discussion: Over half of patients were no longer on opioid therapy by the end of the study. Most patients had a disorder (e.g., back pain) for which opioids are generally not recommended. Overall mean opioid dose was reduced from baseline by approximately 60% over 1 year. Lack of access to specialized pain treatments may have accounted for high nonopioid pharmacotherapy usage. Conclusions: This study demonstrates that treatment of CNCP and opioid tapering can successfully be achieved in a primary care setting. Can Pharm J (Ott) 2020;153:xx-xx.
Composition is the Core Driver of the Language-selective Network

The frontotemporal language network responds robustly and selectively to sentences. But the features of linguistic input that drive this response and the computations that these language areas support remain debated. Two key features of sentences are typically confounded in natural linguistic input: words in sentences (a) are semantically and syntactically combinable into phrase- and clause-level meanings, and (b) occur in an order licensed by the language’s grammar. Inspired by recent psycholinguistic work establishing that language processing is robust to word order violations, we hypothesized that the core linguistic computation is composition, and, thus, can take place even when the word order violates the grammatical constraints of the language. This hypothesis predicts that a linguistic string should elicit a sentence-level response in the language network provided that the words in that string can enter into dependency relationships as in typical sentences. We tested this prediction across two fMRI experiments (total N = 47) by introducing a varying number of local word swaps into naturalistic sentences, leading to progressively less syntactically well-formed strings. Critically, local dependency relationships were preserved because combinable words remained close to each other. As predicted, word order degradation did not decrease the magnitude of the blood oxygen level–dependent response in the language network, except when combinable words were so far apart that composition among nearby words was highly unlikely. This finding demonstrates that composition is robust to word order violations, and that the language regions respond as strongly as they do to naturalistic linguistic input, providing that composition can take place.
Language Processing as a Precursor to Language Change: Evidence From Icelandic

One of the main characteristics of human languages is that they are subject to fundamental changes over time. However, because of the long transitional periods involved, the internal dynamics of such changes are typically inaccessible. Here, we present a new approach to examining language change via its connection to language comprehension. By means of an EEG experiment on Icelandic, a prominent current example of a language in transition, we show that the neurophysiological responses of native speakers already reflect projected changes that are not yet apparent in their overt behavior. Neurocognitive measures thus offer a means of predicting, rather than only retracing, language change.
Effectiveness of Lifelong ART (Option B+) in the Prevention of Mother-to-Child Transmission of HIV Programme in Zambia: Observations Based on Routinely Collected Health Data

Background: Mother to child transmission of HIV (MTCT) is a global challenge affecting many countries especially in sub-Saharan Africa. In 2009 about 370,000 infants were infected with HIV mainly through MTCT and most of them in sub-Saharan Africa. We aimed to determine the effectiveness of Option B+ compared to other options in reducing rates of early MTCT of HIV infections in Zambia. Methods: This was a retrospective cohort study based on routinely collected data using SmartCare in Zambia. Survival analysis with Cox Proportional Hazard regression was used to determine association between MTCT and regimen type of mothers. Kaplan-Meier (K-M) curves were used to compare MTCT for infants born to mothers option B+ to those on other options, and Wilcoxon (Breslow) test was used to establish statistical significance. Results: Overall (n = 1,444), mother-baby pairs with complete data were included in the analysis, with the median age of mothers being 33 (28–38) years; and 57% of these women were on Option B+. MTCT rate was estimated at 5% (73/1,444) [P = 0.025]. A Kaplan-Meier estimate showed that HIV Exposed Infants (HEI) of mothers on Option B+ had lower MTCT rate than those who were on other MTCT prevention interventions [Wilcoxon test; chi2 = 4.97; P = 0.025]. Furthermore, The Nelson Aalen cumulative hazard estimates indicated similar evidence of option B+ being more effective than other options with some statistical significance [HR = 0.63, P = 0.068]. HEI of option B+ mothers had 50% reduced risk of having HIV infection compared to option A/B [adjusted HR = 0.4; 95% CI = 0.28–0.84; P = 0.010]. HEI to women who were married had an increased risk 50% of getting infected compared to those not married [adjusted HR = 1.5; 95% CI = 3.43–6.30; P < 0.001]. Exposed infants whose mothers had assisted delivery had 3 times increased risk of getting infected compared to those born through normal vaginal delivery [Adjusted HR = 3.2; 95% CI = 0.98–10.21; P = 0.050]. Conclusions: The use of Option B+ as PMTCT intervention was found to be more effective in reducing MTCT of HIV compared to other options. Scaling up access to life-long ART and improving retention for women on treatment can potentially reduce further vertical transmission.
Heart Rhythm Analyzed via Shapelets Distinguishes Sleep From Awake

Automatically determining when a person falls asleep from easily available vital signals is important, not just for medical applications but also for practical ones, such as traffic safety or smart homes. Heart dynamics and respiration cycle couple differently during sleep and awake. Specifically, respiratory modulation of heart rhythm or respiratory sinus arrhythmia (RSA) is more prominent during sleep, as both sleep and RSA are connected to strong vagal activity. The onset of sleep can be recognized or even predicted as the increase of cardio-respiratory coupling. Here, we employ this empirical fact to design a method for detecting the change of consciousness status (sleep/awake) based only on heart rate variability (HRV) data. Our method relies on quantifying the (self)similarity among shapelets – short chunks of HRV time series – whose “shapes” are related to the respiration cycle. To test our method, we examine the HRV data of 75 healthy individuals recorded with microsecond precision. We find distinctive patterns stable across age and sex, that are not only indicative of sleep and awake, but allow to pinpoint the change from awake to sleep almost immediately. More systematic analysis along these lines could lead to a reliable prediction of sleep.
Expression Pattern and Functional Characterization of PISTILLATA Ortholog Associated With the Formation of Petaloid Sepals in Double-Flower Eriobotrya japonica (Rosaceae)

Double-flower Eriobotrya japonica, of which one phenotype is homeotic transformation of sepals into petals, is a new germplasm for revealing the molecular mechanisms underlying the floral organ transformation. Herein, we analyzed the sequence, expression pattern and functional characterization of EjPI, which encoded a B-class floral homeotic protein referred to as PISTILLATA ortholog, from genetically cognate single-flower and double-flower E. japonica. Phylogenetic analysis suggested that the EjPI gene was assigned to the rosids PI/GLO lineage. Analysis of protein sequence alignments showed that EjPI has typical domains of M, I, K, and C, and includes a distinctive PI motif at the C-terminal region. Compared with asterids PI/GLO lineage, the K1 and K3 subdomains of EjPI both contain a single amino acid difference. Subcellular localization of EjPI was determined to be in the nucleus. Expression pattern analysis revealed that EjPI expressed not only in petals, filament, and anther in single-flower E. japonica, but also in petaloid sepals in double-flower E. japonica. Meanwhile, there were high correlation between EjPI transcript level and petaloid area within a sepal. Furthermore, 35S::EjPI transgenic wild-type Arabidopsis caused the homeotic transformation of the first whorl sepals into petaloid sepals. Ectopic expression of EjPI in transgenic pi-1 mutant Arabidopsis rescued normal petals and stamens. These results suggest expression pattern of EjPI is associated with the formation of petaloid sepal. Our study provides the potential application of EjPI for biotechnical engineering to create petaloid sepals or regulate floral organ identity in angiosperms.
Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan

Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially and temporally regulated by intrinsic and extrinsic factors. One important extrinsic factor is the extracellular matrix, the non-cellular component of tissues. Heparan sulfate proteoglycans (HSPGs) are constituents of the extracellular matrix, and through their heparan sulfate chains and protein core, modulate multiple events that occur during the metastatic cascade. This review will provide an overview of the role of the extracellular matrix in the events that occur during cancer metastasis, primarily focusing on perlecan. Perlecan, a basement membrane HSPG is a key component of the vascular extracellular matrix and is commonly associated with events that occur during the metastatic cascade. Its contradictory role in these events will be discussed and we will highlight the recent advances in cancer therapies that target HSPGs and their modifying enzymes.
The Risks and Outcomes Resulting From Medication Errors Reported in the Finnish Tertiary Care Units:

Background: Hospital-acquired medication errors (MEs) are common in health care. Although voluntary reporting is criticized for not producing reliable estimates on ME frequency, it provides valuable knowledge on errors occurring in the medication process. Objective: The purpose of this study was to analyze and determine the risks and outcomes resulting from MEs related to the TOP15 medicines in the Finnish tertiary care units from July 2016 to July 2017. Methods: The data consisting of 1,447 ME reports was organized according to ATC classification, after which TOP15 medicines involved in the reports were selected. Inductive content analysis was performed to the reports. After this, the reports were categorized by ME outcome into five categories and further analyzed accordingly. Results: The most common ME outcome in the reports was “omitted medicine” (33.9%). More than a quarter (27.1%) of ME reports were estimated to cause moderate or severe risk to the patient. When compared with each other, none of the outcome groups were more susceptible to high-risk events (p = 0.71). Of the TOP15 medicines, only Norepinephrine had significantly higher risk of being involved in high-risk events (OR 2.43, 95%CI 1.35–4.61). Conclusion: Voluntary reporting has an important role in the development of medication safety and the overall medication process within organizations. Although majority of the TOP15 medicines were involved in MEs resulting in seemingly high-risk outcomes, they were estimated to be insignificant or minor within the reporting unit. In the future, more emphasis will be needed for the assessment and analysis of the reports for more efficient, real-time detection and response to signals from health care units.
Failure behavior of woven fiberglass composites under combined compressive and environmental loading

The purpose of this study is to quantitatively characterize the compressive and damage behavior of a woven fiberglass composite under combined environmental loading. Cuboidal samples of a commercially available woven fiberglass epoxy resin composite, garolite G10, are examined under uniaxial compressive loading perpendicular to the plies at quasi-static (10−3 s−1) and dynamic (103 s−1) strain rates using a standard load frame and Kolsky (split-Hopkinson) bar. In order to simulate environmental conditions, a subset of samples were soaked in either distilled or ASTM standard seawater prior to loading. Two time periods of environmental conditioning were investigated: short term at two weeks and long term at four months. Results demonstrate that, on average, the dynamic compressive strength of the fiberglass increased 35% from the quasi-static. Moreover, environmentally treated samples generally experienced a decrease strain to failure, and composites exposed to water for only short periods exhibited signs of the absorbed water sustaining additional load under quasi-static rates. Ultra-high-speed photography combined with digital image correlation, a full-field surface kinematic measurement technique, is used to map 2D strains on the sample during loading. In all cases, a clear shear failure mechanism from local instabilities appears, and a Mohr–Coulomb failure criterion is used to extract a mesoscale cohesive shear stress and coefficient of internal friction.