Miracle-dz/UniFAR-FTUs huggingface dataset:
IL-1α and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases

Inflammation driven by environmental allergens is an important source of morbidity in diseases such as asthma and eczema. How common allergens promote inflammation is still poorly understood, but previous studies have implicated the protease activity associated with many allergens as an important component of the pro-inflammatory properties of these agents. The IL-1 family cytokine, IL-33, has recently been shown to undergo processing and activation by proteases associated with multiple common allergens. However, it remains unclear whether the sensing of exogenous protease activity—as a proxy for the detection of invasive microbes, allergens and parasitic worms—is a general property of IL-1 family cytokines. In common with the majority of IL-1 family members, cytokines within the IL-36 sub-family (IL-36α, IL-36β and IL-36γ) are expressed as inactive precursors that require proteolysis within their N-termini for activation. Here we show that proteases associated with multiple common allergens of plant, insect, fungal and bacterial origin (including: Aspergillus fumigatus, ragweed, rye, house dust mite, cockroach and Bacillus licheniformis) are capable of processing and activating IL-36 family cytokines, with IL-36β being particularly susceptible to activation by multiple allergens. Furthermore, extracts from several allergens also processed and enhanced IL-1α activity. This suggests that multiple IL-1 family cytokines may serve as sentinels for exogenous proteases, coupling detection of such activity to unleashing the pro-inflammatory activity of these cytokines. Taken together with previous data on the diversity of proteases capable of activating IL-1 family cytokines, this suggests that members of this cytokine family may function as ‘activity recognition receptors’ for aberrant protease activity associated with infection, tissue injury or programmed necrosis.
The Origin of the Coronal Lines in Seyfert Galaxies

This paper examines the possibility that the coronal line region in Seyfert galaxies may be the result of an interstellar medium (ISM) exposed to, and subsequently photoionized by, a 'bare' Seyfert nucleus. It is shown that a 'generic' AGN continuum illuminating the warm-phase of the ISM of a spiral galaxy can produce the observed emission. In this picture the same UV-radiation cone that is responsible for the high-excitation extended narrow-line emission clouds observed out to 1-2 kpc or farther from the nuclei of some Seyfert galaxies also produces the coronal lines. Soft X-rays originating in the nucleus are Compton-scattered off the ISM, thus producing extended soft X-ray emission, as observed in NGC 4151. The results of the calculations show a basic insensitivity to the ISM density, which explains why similar coronal line spectra are found in many Seyfert galaxies of varying physical environments. 60 refs.
Dietary Ferulic Acid Ameliorates Metabolism Syndrome-Associated Hyperuricemia in Rats via Regulating Uric Acid Synthesis, Glycolipid Metabolism, and Hepatic Injury

Ferulic acid is a well-known phenolic acid compound and possesses multiple health-promoting and pharmacological effects. Metabolic syndrome (MetS) and hyperuricemia (HUA) have become health problems worldwide and are closely connected. The aim of this study was to explore the influence of ferulic acid on MetS-related HUA and its underlying mechanisms. Rats were administered high-fructose and high-fat diet (HFFD) with or without ferulic acid (0.05 and 0.1%) for 20 weeks. Intake of HFFD resulted in obesity, hyperglycemia, insulin resistance, and dyslipidemia, which were alleviated by ferulic acid consumption. Treatment of rats with ferulic acid diminished the levels of lipids and inflammatory cytokines and enhanced the activities of antioxidant enzymes in the liver caused by HFFD. Additionally, administration of ferulic acid blocked a HFFD-induced elevation in activities and mRNA expression of enzymes involving in uric acid (UA) synthesis. Molecular docking analysis denoted that ferulic acid bound to the active center of these enzymes, indicative of the potential interaction with each other. These two aspects might partially be responsible for the decrement in serum UA content after ferulic acid ingestion. In conclusion, ferulic acid supplementation ameliorated lipid and glucose metabolic abnormalities, hepatic damage, and UA formation in MetS rats. There was a dose correlation between lipid deposition and UA synthesis-related indicators. These findings implied that ferulic acid could be applied as a promising dietary remedy for the management of MetS-associated HUA.
Diagnóstico da tuberculose em pessoas idosas: barreiras de acesso relacionadas aos serviços de saúde

Este estudo tem como objetivo analisar as barreiras ao diagnostico da tuberculose em idosos relacionadas aos servicos de saude no municipio de Joao Pessoa-PB. Trata-se de pesquisa qualitativa que envolveu sete pessoas idosas doentes de tuberculose. Entrevistas foram utilizadas para coletar informacoes. O material empirico foi organizado com o software Atlas.tiversao 6.0 e analisado conforme a tecnica de analise de discurso. As barreiras relacionadas ao acesso para confirmacao diagnostica foram: horario de funcionamento das unidades de saude da familia; transferencia de responsabilidades; visitas domiciliares sem controle de comunicantes; demora do servico de saude em suspeitar da doenca e repetidas idas do doente ao servico de saude para a obtencao do diagnostico. Apesar de terem sido identificadas barreiras comuns as encontradas por doentes de tuberculose de um modo geral, em virtude da vulnerabilidade dos idosos, sugerem-se que acoes de controle sejam empreendidas pelos servicos de saude de modo a evitar que a doenca torne-se um agravo comum para essa populacao.
WHY THE VAULT BECAME SUPERIOR TO OTHER EVENTS IN WOMEN’S ARTISTIC GYMNASTICS AT THE OLYMPICS?

Critics argue that disciplines in women’s artistic gymnastics are not equal and the vault is generally scored much higher than the uneven bars, balance beam and floor exercise. The aim of this study is to understand why the vault became superior to other women’s events. The data are the official results for the 586 women gymnasts in Qualification at Olympics from 2000 to 2020. The One-Way ANOVA was used to analyze the variance of D-scores, E-scores and F-scores for women gymnasts obtained on each apparatus. Our research shows that disciplines in women’s artistic gymnastics have not been equal for gymnasts when trying to obtain high F-scores in the past 6 Olympics. Among the four women’s events, the vault came to be the one on which gymnasts are more likely to obtain high F-scores after the 2000 Olympics. We indicate that the strength of vault resulted from the introduction of the new vaulting table in 2001 and the new open-ended rules in 2006. Although the two big changes implemented by the International Federation of Gymnastics in the beginning of the new millennium were aimed at improving safety of the vault and fairness of judging, the interplay of the two big changes unintentionally promoted the vault to become the most powerful event in women’s artistic gymnastics. Such unanticipated consequence of purposeful action may constitute the most important element (i.e., imbalance of disciplines) in the sport. Accordingly, this research has the potential to shed new light on not only this important topic of equality between disciplines, but also broader trends in modern artistic gymnastics.
Suction thrombectomy using a microcatheter as a salvage method for acute distal occlusion during cerebral aneurysm embolization: A case report

The aneurysm coiling process presents a risk of thromboembolic complications, mostly in patients with ruptured aneurysms, given the fact that they cannot receive antiplatelet therapy. Management strategies include medical anticoagulation or antiplatelet therapy, intra-arterial thrombolysis, and mechanical thrombectomy using direct aspiration first-pass technique or stent retrievers. We report our own experience of using an Excelsior SL-10 Microcatheter (Stryker, Fremont, California, USA) with an internal diameter of 0.0165”, originally designed for coil delivery, for contact aspiration of a thrombotic occlusion of a distal anterior cerebral artery during coiling of a broad-based trilobar anterior communicating artery aneurysm. The clot was removed under continuous manual aspiration, and complete recanalization has been accomplished. Mechanical thrombectomy through microcatheter aspiration may be a safe and feasible treatment option for acute distal artery occlusions, especially in the case of tortuous distal vessels during embolization of cerebral aneurysms.
Construction of Tissue-Engineered Bladder Scaffolds with Composite Biomaterials

Various congenital and acquired urinary system abnormalities can cause structural damage to patients’ bladders. This study aimed to construct and evaluate a novel surgical patch encapsulated with adipose-derived stem cells (ADSCs) for bladder tissue regeneration. The surgical patch consists of multiple biomaterials, including bladder acellular matrix (BAM), collagen type I from rat tail, microparticle emulsion cross-linking polylactic-co-glycolic acid (PLGA)-chitosan (CS) with PLGA-sodium alginate (SA), and growth factors. ADSCs were seeded on the surgical patch. Approximately 50% of the bladder was excised and replaced with a surgical patch. Histological, immunohistochemical and urodynamic analyses were performed at the 2nd, 4th, and 8th weeks after surgery, respectively. The PLGA-CS, PLGA-SA or surgical patch showed no cytotoxicity to ADSCs. PLGA-CS cross-linked with PLGA-SA at a ratio of 5:5 exhibited a loose microporous structure and was chosen as the candidate for ADSC seeding. We conducted bladder repair surgery in rats using the patch, successfully presenting urothelium layers, muscle bundles, and vessel regeneration and replacing 50% of the rat’s natural bladder in vivo. Experiments through qualitative and quantitative evaluation demonstrate the application potential of the composite biomaterials in promoting the repair and reconstruction of bladder tissue.
COTTON INTROGRESSIVE LINES ASSESSMENT THROUGH SEED COTTON YIELD AND FIBER QUALITY CHARACTERISTICS

The conducted study, with focus on the earliness and opening rate of bolls, and other economic traits of introgressive cotton lines, was carried out from 2017 to 2019 at the Institute of Genetics and Plant Experimental Biology, and Genetics and Evolution Biology Department, in Chirchik State Pedagogical Institute, Tashkent, Uzbekistan. Overall, the introgressive cotton lines were found to ripen two to 13 days earlier than a standard cotton cultivar C-6524. Particularly, in line L-РСМ, the vegetation period took 109 days and matured 12.3 days earlier than a standard cultivar check. According to the boll weight, the selected cotton lines were identified to have the best performance, as well as, good germination ability of seeds. The cotton line, Т-138, was found highly resistant to strains of Fusarium oxysporum f. sp. vasinfectum pathogenic fungi, while the lines, L-РСМ and L-138, had 80% to 100% resistance to Verticillium dahliaе fungi. The cotton lines, L-РСМ and L-141, were not infected with Fusarium solani fungi. The cluster analysis revealed that according to the economic traits, the first cluster included lines L-24 and L-138 and were found to be closely related to each other. The line, L-РСМ, was included in the third cluster, and it was found that this cotton line was among the cultivars with the best performance for all the valuable economic traits. The comparative analysis of cotton lines resulted in a creation of a new medium-fiber cotton cultivar “Niso,” with the productivity of 3,830 to 5,650 kg ha-1, boll weight of 6.0 to 6.7 g, boll opening at 109.0 to 112.0 days, type IV fiber, 1000-seed weight of 118.0 to 120.0 g, fiber percentage ranging from 36.9% to 41.4%, fiber length at 34.0 to 35.9 mm, and relative tensile strength (34.6 cN/tex). Cotton lines obtained on the basis of intergenomic introgression methods were included in the leading “Cotton gene pool” (Reference of the Academy of Sciences of the Republic of Uzbekistan №4/1255-2473 dated November 12, 2020). These introgressive cotton lines made it possible to enrich the collection of cotton, to evaluate wild cotton species, and to form a system of information and analysis of the electronic database of adaptable stress factors and genetically enriched samples.
Seroprevalence and risk factors of bluetongue virus in sheep of Chattogram, Bangladesh

Background and Aim: Bluetongue (BT) is a non-contagious, infectious disease of wild and domestic ruminant animals caused by the BT virus (BTV). Bangladesh having a border with a BTV-endemic country, India and a substantial number of susceptible animals. Therefore, this study aimed to estimate BTV seroprevalence and potential risk factors. Materials and Methods: We collected 150 serum samples from indigenous sheep from Chattogram, Bangladesh. We screened the serum samples using a competitive enzyme-linked immunosorbent assay for detecting BTV-specific immunoglobulin. Results: We detected antibodies against BTV in 39.3% (59/150; 95% confidence interval: 31.5–47.6) of all sampled sheep. Factors like sampling site, sheep rearing location, rearing sheep with other farm species, and body condition score had a significant (p < 0.05) influence on the seroprevalence of BTV. Conclusion: The findings show that indigenous sheep have a higher BTV seroprevalence, necessitating sustained surveillance for early diagnosis and a better understanding of virus epidemiology in Bangladesh.
Estimating the Level of Interleukin-22 in Sera of Patients with Uropathogenic Escherichia coli Infection in Mosul City

Background: Urinary tract infections (UTIs) were infectious diseases of the urinary system, that were caused by the different causative agents, including fungi, parasites, viruses, and bacteria. The current study was designed to isolate different bacteria from UTI and choose E. coli isolates to study levels of interleukin-22 in patients infected with it. Furthermore, studying the prevalence of type 1 fimbriae ( fim H) virulence gene from isolated E. coli of above patients. Methods: In the present study, a total of (140) midstream urine and serum samples were collected from patients (110 females and 30 males) with the age ranged between 10 to 65 years, who had signs and symptoms and primarily diagnosed with UTI by physician in Al-Salam Teaching Hospital – Mosul/Iraq during the period between January and March 2021, while thirty-four healthy individuals were studied as controls for the ELISA test. Identification of bacterial isolates was done by microscopical examination, biochemical tests, and (API 20E). Furthermore, disc diffusion method was used in antibiotic sensitivity test, and DNA from E. coli isolates was extracted for gene detection. In addition, serum interleukin-22 level was determined via ELISA technique. Results: The mean ± SD age in UTI patients were (32.95 ± 12.80) years, while in the healthy controls group were (35.55 ± 13.51) years. Additionally, E. coli were the most common isolated bacteria from the patient group with a frequency and percentage of 50 (35.7%). Furthermore, when compared to the control group, serum IL- 22 level was significantly higher in the patient's group due to E. coli infection (P<0.001). Moreover, the prevalence of the fim H gene in E. coli isolates was 47 (94.0%) were positive for that gene. Conclusion : The present study revealed that E. coli was the most bacterial infection in patients with urinary tract infection, while the highest E. coli sensitivity was to Meropenem, Nitrofurantoin (F15) and Chloramphenicol also the higher serum IL- 22 level in patients with UTIs due to E. coli compared to controls group. Therefore, IL-22 could be used as a biomarker for UTI. Additionally, the prevalence of the fim H gene in E. coli isolates was present in most isolates. estimate the of IL-22 in gene in of E. by Chain
Impact of TQM and Technology Management on Organizational Performance

In the growing business competitiveness TQM (Total Quality Management) and TM (Technology Management) practices have become important for organizational success. TQM fosters business excellence while TM helps to deal with process and product related technological challenges. However, in literature TM has received little consideration with TQM. This paper is a research study that attempts to identify any combined relationship of both concepts with OP (Organizational Performance) while taking into account different organizational contextual factors including ISO-9001 certification. Responses from 86 different organizations in Pakistan are collected through questionnaire survey and random sampling. Statistical analysis shows that OP is positively associated to TQM and TM. Results of this study indicate the significance of ISO-9001 certification for TQM but do not support it for OP. It is also observed that organizations of private sector are significantly better in TQM and TM practices, so in OP, in comparison to government or public sector organizations. The study contributes to explore and augment both practices for implementation to improve OP.
The effect of hydrogen peroxide prepared with silver ions on the qualitative traits of table eggs and reducing the dynamics of mycobiota growth

The quality and safety of raw materials and food products are inextricably linked. Table eggs are subjected to special monitoring due to the microbial hazards. So far, bacterial hazards have been monitored on table eggs. However, latest reports have pointed a threat that has not been considered for table eggs, which is microfungi. Microfungi can grow on the surface of eggshells and penetrate inside the eggs. Therefore, it is necessary to improve the microbiological state of the eggshells surface, which will guarantee the safety of egg consumption and also reduce spoilage. Therefore, the aim of the present work was to examine on how egg sanitation with prepared hydrogen peroxide (H2O2) containing silver ions affected the growth dynamics of microfungi and the production of mycotoxins during egg storage. The results showed that H2O2 with silver ions was effective against microfungi, while simultaneously inhibited production of mycotoxins. The egg sanitation treatment with a solution of H2O2 with silver ions reduced the count of microfungi and stopped growing after one week of storage. The effectiveness of lower concentrations of the prepared solution against the microfungi may have been caused by silver ions. There was a small decrease in Haugh unit value of eggs sanitised with H2O2 and silver ions in the final period of storage. The results showed that the treatment of eggs with H2O2 with silver ions slowed down the spoilage process and effectively reduced the content of microfungi and mycotoxins.
Impact of histological clot composition on preprocedure imaging and mechanical thrombectomy

INTRODUCTION: We studied the relationship of acute ischemic stroke (AIS) large-vessel occlusion clot composition with vessel recanalization and preprocedure imaging. SUBJECTS AND METHODS: Individual clots from AIS patients who underwent mechanical thrombectomy (MT) between September 2016 and September 2018 were examined. Clot composition was analyzed histologically through a trichrome staining and image segmentation, and the area occupied by red blood cells (RBCs), fibrin, or mixed composition was quantified. RESULTS: Forty-three patients (65.4 ± 12.7 years, 39% of females) who underwent 92 retrieval passes (mean 2.14, range 1–6) were included in this study. Fibrin (44%) occupied the greatest area, followed by mixed composition (34%) and RBCs (22%). A stent retriever was deployed in 81% of cases, 20 patients (47%) achieved first-pass efficacy (FPE) (thrombolysis in cerebral infarction [TICI] 2b-3 after first pass), 41 (95%) achieved successful revascularization (TICI 2b-3), and 21 (49%) had good outcome (modified Rankin Scale [mRS] ≤2) at 90 days. Hyperdense artery sign (HAS) on initial computed tomography was correlated with mixed clot composition (P = 0.01) and lack of fibrin content (P = 0.03). In the univariate analysis, FPE was associated with RBC clot area, atrial fibrillation, and occlusion location but not with fibrin clot area, mixed clot area, stroke etiology, thrombectomy technique, distal emboli, or 90-day mRS. In the multivariate analysis, FPE was significantly correlated with low RBC clot area (odd ratio = 0.96, confidence interval [0.92.99], P = 0.034) but not with atrial fibrillation or location. CONCLUSION: Our results suggest that HAS is correlated with mixed clot composition and lower fibrin content and that lower RBC clot composition is associated with FPE in patients undergoing MT.
Turning to Nature to Process the Emotional Toll of Nature’s Destruction

As challenges emerge in the context of the Anthropocene, one often overlooked area is the emotional toll that the Earth’s destabilisation has on the human psyche. Deeper investigation into perceived “negative” emotions of the Anthropocene requires closer attention if those in highly industrialised societies, as the major contributors to the climate crisis, are to avoid collective denial and move towards transformative change. This paper aims to provide insights into these “negative” emotions that are emerging in Australia in response to changes to the biosphere and the destruction of nature, including sadness, grief, anger, frustration, and anxiety. As a way of processing these “negative” emotions, the authors find that connecting with, and being in, nature is critical. Such connection allows people to cope, renew, and heal. In this way, nature is both the trigger for, and answer to, our ecological grief, anger, and anxiety, and, as such, is at the epicentre of human emotions in the context of the Anthropocene.
Deformation Styles and Multi-Stage Evolution History of a Large Intraplate Strike-Slip Fault System in a Paleozoic Superimposed Basin: A Case Study From the Tarim Basin, NW China

The complex deformation styles of large intraplate strike-slip fault systems in the multi-stage superimposed basin are hot topics worldwide. This article proposes structural models and evolution processes for such strike-slip fault systems in the Tarim Basin based on high-resolution 3D seismic data and deep wells. Our analyses reveal that strike-slip fault in the Tarim Basin formed with different structural styles in five tectonic layers from the Sinian to the Permian that accompanies the Sinian rift systems and uplift, the Lower–Middle Cambrian reversed faults and salt tectonics, the Ordovician fault-karst systems, the Silurian to the Carboniferous en-echelon transtensional faults, and the Permian volcanic structures. Influenced by the multi-tectonic layers and complex evolution history, the strike-slip faults performed as multi-layer flower structures and various fault types. The evolution history of paleo-uplifts also influenced the distribution characteristics of strike-slip faults, such as X, diamond, and V shapes in the Tabei uplift and T shapes in the Tazhong uplift. The strike-slip faults formed in late Cambrian stage were associated with unconformities, inverted structures, and growth strata in deep layers. The different tectonic evolution models of the Tabei and the Tazhong uplift were built, which shows pre-existing structures, the lithological combinations from the rift basin to the marine basin, and the change of regional tectonic stress from the Cambrian to Permian are controlling factors of the strike-slip fault systems. These models provide a new interpretation method for intraplate strike-slip fault systems worldwide.