Miracle-dz/UniFAR-FTUs huggingface dataset:
European heat waves 2022: contribution to extreme glacier melt in Switzerland inferred from automated ablation readings

Abstract. Accelerating glacier melt rates were observed during the last decades. Substantial ice loss occurs particularly during heat waves that are expected to intensify in the future. Because measuring and modelling glacier mass balance on a daily scale remains challenging, short-term mass balance variations, including extreme melt events, are poorly captured. Here, we present a novel approach based on computer-vision techniques for automatically determining daily mass balance variations at the local scale. The approach is based on the automated recognition of colour-taped ablation stakes from camera images and is tested and validated at six stations installed on three Alpine glaciers during the summers of 2019–2022. Our approach produces daily mass balance with an uncertainty of ±0.81 cm w.e. d−1, which is about half of the accuracy obtained from visual readouts. The automatically retrieved daily mass balances at the six sites were compared to average daily mass balances over the last decade derived from seasonal in situ observations to detect and assess extreme melt events. This allows analysing the impact that the summer heat waves which occurred in 2022 had on glacier melt. Our results indicate 23 d with extreme melt, showing a strong correspondence between the heat wave periods and extreme melt events. The combination of below-average winter snowfall and a suite of summer heat waves led to unprecedented glacier mass loss. The Switzerland-wide glacier storage change during the 25 d of heat waves in 2022 is estimated as 1.27 ± 0.10 km3 of water, corresponding to 35 % of the overall glacier mass loss during that summer. The same 25 d of heat waves caused a glacier mass loss that corresponds to 56 % of the average mass loss experienced over the entire melt season during the summers 2010–2020, demonstrating the relevance of heat waves for seasonal melt.
A Study of Hawaiian Warm Rain Showers Based on Aircraft Observation

Abstract Warm rain off the island of Hawaii was followed by aircraft beneath the cloud base from the beginning of the shower to the end, and newly designed instruments were used to observe time and spatial distributions of rainwater content and raindrop size distribution as a function of cloud-top height. Based on 110 h of observation, rain showers were classified into two main groups: isolated showers and line showers. Isolated showers were subdivided into base showers (showers developing under the cloud base) and side showers (showers developing outside of the cloud area). Line showers were subdivided into showers moving at right angles to the cloud line, showers moving parallel to the cloud line, standing showers and showers which formed successively upwind of the present shower line. These cloud classes are intimately related to the profile of upper wind. Two shower peaks, with weak showers at the cloud center are observed along the flight line when the upper wind is weak, irrespective of cloud type, .
The Art of Temporal Approximation: An Investigation into Numerical Solutions to Discrete and Continuous-Time Problems in Economics

A recent literature within quantitative macroeconomics has advocated the use of continuous-time methods for dynamic programming problems. In this paper we explore the relative merits of continuous-time and discrete-time methods within the context of stationary and nonstationary income fluctuation problems. For stationary problems in two dimensions, the continuous-time approach is both more stable and typically faster than the discrete-time approach for any given level of accuracy. In contrast, for convex lifecycle problems (in which age or time enters explicitly), simply iterating backwards from the terminal date in discrete time is superior to any continuous-time algorithm. However, we also show that the continuous-time framework can easily incorporate nonconvexities and multiple controls—complications that often require either problem-specific ingenuity or nonlinear root-finding in the discrete-time context. In general, neither approach unequivocally dominates the other, making the choice of one over the other an art, rather than an exact science. Code can be found at https://github.com/tphelanECON/The Art of Temporal Approximation WP.
Outcomes of a Multidisciplinary Team in the Management of Patients with Early-Stage Breast Cancer Undergoing Neoadjuvant Chemotherapy at a Community Cancer Center

Background: The utilization of neoadjuvant chemotherapy (NAC) remains highly variable in clinical practice. The implementation of NAC requires coordination of handoffs between a multidisciplinary team (MDT). This study aims to assess the outcomes of an MDT in the management of early-stage breast cancer patients undergoing neoadjuvant chemotherapy at a community cancer center. Methods: We conducted a retrospective case series on patients receiving NAC for early-stage operable or locally advanced breast cancer coordinated by an MDT. Outcomes of interest included the rate of downstaging of cancer in the breast and axilla, time from biopsy to NAC, time from completion of NAC to surgery, and time from surgery to radiation therapy (RT). Results: Ninety-four patients underwent NAC; 84% were White and mean age was 56.5 yrs. Of them, 87 (92.5%) had clinical stage II or III cancer, and 43 (45.8%) had positive lymph nodes. Thirty-nine patients (42.9%) were triple negative, 28 (30.8%) were human epidermal growth factor receptor (HER-2)+, and 24 (26.2%) were estrogen receptor (ER) +HER-2−. Of 91 patients, 23 (25.3%) achieved pCR; 84 patients (91.4%) had downstaging of the breast tumor, and 30 (33%) had axillary downstaging. The median time from diagnosis to NAC was 37.5 days, the time from completion of NAC to surgery was 29 days, and the time from surgery to RT was 49.5 days. Conclusions: Our MDT provided timely, coordinated, and consistent care for patients with early-stage breast cancer undergoing NAC as evidenced by time to treatment outcomes consistent with recommended national trends.
The Energy-Saving Potential of a Green Roof on Existing Residential Buildings. A Case Study of Jubail Industrial City, Saudi Arabia.

-Residential buildings are the major sector in the construction industry that consume energy and affect the whole environment. Controlling these effects has always been the foremost concern, especially the existing ones. This paper addresses a case study of existing residential buildings at Jubail Industrial City in the Kingdom of Saudi Arabia, where the units are reproduced all over the districts. With proper design and maintenance, green roofs can provide cost-effective and sustainable solutions for existing residential buildings. The best set of strategies through the Climate Consultant software have been studied where the strategy of adding the green roof comes as a priority for the selected city. Green roofs, also known as vegetated roofs or rooftop gardens, offer a wide range of benefits for existing residential buildings. These benefits include improved insulation, reduction of stormwater runoff, increased biodiversity, and improved air quality. In addition, green roofs can also provide aesthetic and recreational benefits for residents. Green roofs can reduce a building’s energy consumption, lower urban heat island effects, and extend the roof's life. By using the green roofs suitable type for the existing buildings and simulating the two scenarios for the existing and the proposed cases using the Design Builder software, while using Climate Consultant software recommends strategies, results revealed that the green roof option could reduce the total energy consumption by at least 8.8 %. Besides benefiting the building's users, this approach will provide an economical solution to protect the environment in terms of reducing power consumption
Sciatic Nerve Block Combined with Flurbiprofen Inhibits Spinal Cord Inflammation and Improves Postoperative Pain in Rats with Plantar Incision

Background and Purpose Peripheral nerve block is often used to relieve postoperative pain. But the effect of nerve block on inflammatory response is not fully understood. Spinal cord is the primary center of pain processing. This study is to investigate the effect of single sciatic nerve block on the inflammatory response of the spinal cord in rats with plantar incision and the combined effect with flurbiprofen. Methods The plantar incision was used to establish a postoperative pain model. Single sciatic nerve block, intravenous flurbiprofen or the combination of both were used for intervention. The sensory and motor functions after nerve block and incision were evaluated. The changes of IL-1β, IL-6, TNF-α, microglia and astrocytes in the spinal cord were examined by qPCR and immunofluorescence respectively. Results Sciatic nerve block with 0.5% ropivacaine in rats induced sensory block for 2h and motor block for 1.5h. In the rats with plantar incision, the single sciatic nerve block did not alleviate postoperative pain or inhibit the activation of spinal microglia and astrocytes, but the levels of IL-1β and IL-6 in spinal cord were decreased when the nerve block wore off. The combined effect of a single sciatic nerve block and intravenous flurbiprofen not only decreased the levels of IL-1β, IL-6, and TNF-α, but also relieved the pain and alleviated the activation of microglia and astrocytes. Conclusion The single sciatic nerve block cannot improve postoperative pain or inhibit the activation of spinal cord glial cells, but can reduce the expression of spinal inflammatory factors. Nerve block combined with flurbiprofen can inhibit spinal cord inflammation and improve postoperative pain. This study provides a reference for rational clinical application of nerve block.
Impacts of Mir146a Genotypes on Bladder Cancer Risk in Taiwan

The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) in mir146a and mir196a and bladder cancer (BLCA) risk in Taiwan. The genotypes of mir146a rs2910164 and mir196a rs11614913 were determined in 375 BLCA patients and 375 healthy controls using PCR-RFLP methodology, and their associations with BLCA risk were evaluated. The study also measured the serum expression level of mir146a using quantitative RT-PCR. The results showed that the distributions of CC, CG and GG genotypes of mir146a rs2910164 were 31.7%, 45.6% and 22.7% in the control group, and 21.9%, 44.3% and 33.8% in the case group, respectively. In logistic regression analyses, the heterozygous variant genotype CG carriers showed a marginally significant association with increased BLCA risk (OR = 1.41, 95% CI = 0.99–2.01), while the homozygous variant genotype GG carriers had a 2.17-fold increased risk of BLCA (OR = 2.17, 95%CI = 1.46–3.21). Moreover, carriers of the GG/CG genotypes had significantly higher serum levels of mir146a than those with the CC genotype (p < 0.0001), indicating a genotype–phenotype correlation. In contrast, mir196a rs11614913 was not associated with BLCA risk. Therefore, the genotypes of mir146a rs2910164 may serve as a useful biomarker for predicting the risk of BLCA.
Uncorrected soil water isotopes through cryogenic vacuum distillation may lead to a false estimation on plant water sources

Successful use of stable isotopes (δ2H and δ18O) in ecohydrological studies relies on the accurate extraction of unfractionated water from different types of soil samples. Cryogenic vacuum distillation (CVD) is a common laboratory‐based technique used for soil water extraction; however, the reliability of this technique in reflecting soil water δ2H and δ18O is still of concern. This study examines the reliability of a newly developed automatic cryogenic vacuum distillation (ACVD) system. We further assessed the impacts of extraction parameters (i.e. extraction time, temperature and vacuum) and soil properties on the recovery of soil water δ2H and δ18O for the ACVD and traditional cryogenic vacuum distillation (TCVD) systems. Finally, we investigated the potential influence of CVD (ACVD and TCVD) technique on the prediction of plant water uptake through a sensitivity analysis. Both ACVD and TCVD similarly extracted water from the rewetted soils, but none of the CVD systems successfully recovered the isotopic signatures of doped water from soil materials. Mean δ2H offsets of extracted soil water were −2.6 ± 1.3‰ and −2.4 ± 1.7‰ for ACVD and TCVD, respectively, while mean δ18O offsets were −0.16 ± 0.14‰ and −0.39 ± 0.37‰. The isotopic offsets of CVD systems were positively correlated with soil clay content, and negatively correlated with soil water content. Using corrected soil data (with CVD offsets) could improve the prediction of plant water uptake based on its high correlation with the environmental factors. This study identifies the isotopic offsets of CVD systems (i.e. ACVD and TCVD) and provides possible solutions for better predicting plant water sources. Even though, the wide use of CVD techniques probably induce noticeable uncertainties in the prediction of plants water uptake depths. The dataset of soil water extraction in this study will have implications for the technological development of CVD techniques.
Extracapsular Tonsillectomy versus Intracapsular Tonsillotomy in Paediatric Patients with OSAS

Objective: The objective of our study was to compare our experience of intracapsular tonsillotomy performed with the help of a microdebrider usually used for adenoidectomy with results obtained from extracapsular surgery through dissection and from adenoidectomy in cases of people affected with OSAS, linked to adeno-tonsil hypertrophy, observed and treated in the last 5 years. Methods: 3127 children with adenotonsillar hyperplasia and OSAS-related clinical symptoms (aged between 3 and 12 years) underwent tonsillectomy and/or adenoidectomy. A total of 1069 patients (Group A) underwent intracapsular tonsillotomy, while 2058 patients (Group B) underwent extracapsular tonsillectomy, from January 2014 to June 2018. The parameters considered in order to evaluate the effectiveness of the two different surgery techniques taken into consideration were as follows: the presence of possible postoperative complications, represented mainly by pain and perioperative bleeding; the level of postoperative respiratory obstruction compared with the original obstruction through night pulse oximetry, performed 6 months before and after the surgery; tonsillar hypertrophy relapse in Group A and/or the presence of residues in Group B with clinical evaluation performed 1 month, 6 months, and 1 year after the surgery; and postoperative life quality, evaluated through submitting to parents the same survey proposed before the surgery 1 month, 6 months, and 1 year after the surgery. Results: Regardless of the technique used (extracapsular tonsillectomy or intracapsular tonsillotomy), there was a clear improvement in both the obstructive respiratory symptomatology and quality of life in both patient groups, as highlighted by the pulse oximetry and the OSA-18 survey submitted later. Conclusions: Intracapsular tonsillotomy surgery has improved in terms of a reduction in postoperative bleeding cases and pain reduction, with an earlier return to patients’ usual lifestyle. Lastly, using a microdebrider with the intracapsular technique seems to be particularly effective in removing most of the tonsillar lymphatic tissue, leaving only a thin border of pericapsular lymphoid tissue and preventing lymphoid tissue regrowth during one year of follow-up.
Creation of Three-Dimensional Anatomical Vascular and Biliary Models for the Study of the Feline Liver (Felis silvestris catus L.): A Comparative CT, Volume Rendering (Vr), Cast and 3D Printing Study

Simple Summary Vascular liver diseases have been studied in dogs. However, cats are now receiving special attention in veterinary clinics. Therefore, this study focuses on the feline liver with the aim of increasing knowledge on the subjects. Studies on the vascular and biliary system of the feline liver are rare; our literature search found five general studies in manuals, three articles in feline-specific journals, and many others in non-specific studies related to the liver. The feline hepatic parenchyma is traversed by vessels and the biliary system, which can be studied by modern anatomical methods such as vascular and biliary epoxy injections together with diagnostic imaging techniques such as computed tomographic angiography (CTA). The use of three-dimensional (3D) reconstructions (volume rendering) and three-dimensional prints to obtain 3D anatomical prototypes allows for the identification of branches of the arterial, venous and biliary systems and their distribution throughout the liver. We observed that the vascular and biliary structures of the feline liver differ from those of the dog. Finally, we believe that in the future, 3D prototypes could be printed by clinicians to help them in the detection of liver pathology in cats. Abstract In this study, six adult feline cadavers were examined using CTA, 3D printing, and casts injected with epoxy. The aorta, the portal vein, and the gallbladder of 3 feline cadavers were separately injected with a 50% mixture of colored vulcanized latex and hydrated barium sulfate as contrast medium to analyze by CT the arterial, venous and biliary systems. The other three cadavers were injected with a mixture of epoxy resin in the aorta, gallbladder and hepatic veins, separately. After the corrosion and washing process, hepatic vascular and biliary casts were obtained. The images obtained by CT showed the vascular and biliary system using a soft tissue window. For the identification of vascular and biliary structures, the 3D prints together with the 3D reconstructions were analyzed, and the results were compared with the casts obtained with epoxy resin. Each of the arterial, venous and biliary branches associated with each of the liver lobes were identified with the help of the printings. In conclusion, the creation of 3D prototypes of nonpathological feline hepatic parenchyma can be used in the veterinary clinic as a basis for the detection of pathological problems in addition to obtaining future pathological hepatic 3D models.
Occupational therapy students’ perception on mental health recovery: A descriptive qualitative exploration

Introduction: In occupational therapy, emphasis is placed on the complex interplay between the client, the occupation and the environment, providing an opportunity for its practitioners to adopt recovery-oriented outcomes in interventions for people with mental health conditions. In this study, we seek to understand occupational therapy undergraduates’ perceptions of recovery for people with mental health conditions. Method: A qualitative descriptive study was conducted at a university in Singapore, which provides a pre-registration occupational therapy programme. Seventeen undergraduates were recruited (year 1, n = 5; year 2, n = 7 and year 3, n = 5). A semi-structured interview guide was used during the interview. Data collection took place from June to August 2022. Results: Using thematic analysis, two macro themes were discerned: the understanding of mental health conditions and the meanings of recovery. Sub-themes were created under each grouping to describe the data. Conclusions: This study explored the perceptions of mental health recovery among occupational therapy undergraduates. Occupational therapy students appeared to be well-aligned with personal and functional recovery perspectives when providing support for people with mental health conditions. However, there seems to be a need to emphasise the more nuanced aspects of delivering care within the culturally diverse setting of Singapore.
Nomogram Based on Hemoglobin, Albumin, Lymphocyte and Platelet Score to Predict Overall Survival in Patients with T3-4N0-1 Nasopharyngeal Carcinoma

Purpose There is still uncertainty regarding the prognosis of nasopharyngeal carcinoma (NPC) based on hemoglobin, albumin, lymphocytes, and platelets (HALP) score. The aim of this study was to build and verify a nomogram using HALP score to investigate the prognostic value of NPC and identify low-risk patients in T3-4N0-1 NPC to guide treatment options. Patients and methods A total of 568 NPC patients with stage T3-4N0-1M0 were recruited in the study, who were given either concurrent chemoradiotherapy (CCRT) or induction chemotherapy (IC) plus CCRT. The prognostic factors of overall survival (OS) were picked by Cox proportional hazards regression analysis to generate a nomogram, which appraised by discrimination, calibration and clinical utility. Patients were stratified according to risk scores calculated by the nomogram, and compared to the 8th TNM staging system using the Kaplan–Meier methods. Results Multivariate analysis showed that TNM stage, Epstein–Barr virus DNA (EBV DNA), HALP score, lactate dehydrogenase-to-albumin ratio (LAR) and systemic inflammatory response index (SIRI) were independent prognostic indicators for OS, and these factors contained in the nomogram. The nomogram demonstrated a significant enhancement over the 8th TNM staging system in terms of assessing OS (C-index, 0.744 vs 0.615 in the training cohort, P < 0.001; 0.757 vs 0.646 in the validation cohort, P = 0.002). Calibration curves displayed good agreement and the stratification in high-risk and low-risk groups resulted in a significant divergence of Kaplan–Meier curves for OS (P < 0.001). In addition, the decision analysis (DCA) curves confirmed satisfactory discriminability and clinical utility. Conclusion The HALP score was an independent prognostic factor for NPC. The prognostic function of the nomogram for T3-4N0-1 NPC patients was more accurate compared to the 8th TNM system, facilitating personalized treatment planning.
A Grid Is Not a Tree: Toward a Reconciliation of Alexander’s and Martin’s Views of City Form

Christopher Alexander famously declared that “a city is not a tree,” while Leslie Martin declared that “the grid is [a] generator. ” This article investigates how Alexander’s call for overlap, adaptability, and order can indeed be manifested in grid networks, as Martin claimed. Order has been measured using the entropy of street orientation, while adaptability has been denoted by the streets’ betweenness values. Through the analysis of Abu Dhabi’s neighborhoods and global urban areas, the study reveals that overlap, order, and adaptability can coexist in gridded street network. A fine-grain scale of the grid plays a critical role in supporting the quality of urban space. To foster adaptation, planning policies should focus on adaptability providing room for informal and spontaneous growth. We conclude by noting that this approach represents a reconciliation between Christopher Alexander’s views and those of Leslie Martin.