Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of endoxifen levels between male and female breast cancer patients treated with tamoxifen.

578Background: Male breast cancer is rare and accounts for less than 1% of breast cancer diagnoses. The majority of male breast cancers are hormone-receptor positive and tamoxifen is the standard adjuvant hormone treatment. Tamoxifen is metabolized primarily by CYP2D6 and CYP3A4 in the liver to the active metabolite endoxifen, increasingly recognized as a clinically relevant biomarker of therapeutic benefit. Plasma levels of endoxifen above a threshold of 15 nM appear to confer maximal anti-hormonal benefit and potentially improved outcomes. Methods: We have carried out a prospective assessment of endoxifen levels in men with breast cancer followed in a personalized tamoxifen clinic. Eleven men with breast cancer were assessed and compared with age and genotype matched female patients, with both groups initially treated at the usual tamoxifen dose of 20 mg/day. Results: Mean baseline endoxifen levels in male CYP2D6 extensive metabolizers (EM) were significantly lower than female EMs (30.88 ± 5.9 nM versus.
Characteristic Features of Suicidal Drownings

A retrospective study of cases of drowning suicide was undertaken at the Forensic Science Centre in Adelaide, South Australia for the period April 1980 to March 2000. A total of 123 cases were found, with 76 males (age, 16–88 years; average, 50.5 years; standard deviation [SD], 20.1 years) and 47 females (age, 34–88 years; average, 60.6 years; SD, 13.9 years). There were 66 fresh water drownings and 57 saltwater drownings. Female victims were significantly older than male victims for both fresh water and saltwater drownings (P .05 and P .01, respectively). Deaths in young women were rare. No temporal trend in drowning suicides could be shown, with annual numbers varying from 0 to 12 cases (average, 6.15; median, 7). Women preferentially chose the ocean or bath to drown themselves in, whereas males chose rivers, ditches, and lakes. Swimming pools were rarely used for suicide in this population; alcohol use was not usual; and there was often a significant history of mental illness.
NILC at ASSIN 2: Exploring Multilingual Approaches

Recognizing Textual Entailment, also known as Natural Language Inference recognition, aims to identify if it is possible to infer the meaning of a text from another fragment of text. In this work, we investigate the use of multilingual models, through BERT, for recognizing inference and similarity in the ASSIN 2 dataset, an entailment recognition and sentence similarity corpus for Portuguese. We also investigate possible features that could enhance the results, such as similarity scores or WordNet relations. Our results show that a multilingual pre-trained BERT model may be su � cient to outperform the current state-of-the-art in this task for the Portuguese Language. We also show that using other features did not necessarily improve the performance of the model, however deeper studies are needed to investigate the causes for this.
Epidemiology of dental root caries: a review of risk factors

Root surface caries is a common disease among the older adults worldwide. This paper reports on two recent systematic reviews which were conducted to identify the risk factors of root caries, one on risk indicators and one on risk predictors, and to describe their relationship with the prevalence and incidence of root caries. Articles in four electronic databases (PubMed, MEDLINE, EMBASE, and Scopus) published in 1990 to 2018 were searched. Epidemiological studies conducted on general populations and investigated at least one risk factor of root caries were included. Relevant information was extracted by two reviewers independently. The factors were put into five main categories, namely demographic and social background, health behaviors, general health, oral health habits and oral health conditions. Forty crosssectional surveys (78,183 participants in total) and 16 longitudinal cohort studies (7,340 participants in total) from different countries worldwide were included in the reviews. There were positive correlations between dental root caries and age, past root caries experience, exposure of root surfaces and use of tobacco. Negative correlations with socio-economic status and oral hygiene were found. Higher risk of having or developing new root caries were found among the older adults, people with lower socio-economic status, tobacco users, and those with greater root caries experience, more gingival recession and more dental plaque.
Is Indomethacin a New Hope for Post-ERCP Pancreatitis?

TO THE EDITOR: We read with great interest a randomized controlled trial by Sotoudehmanesh et al. (1) titled “Indomethacin May Reduce the Incidence and Severity of Acute Pancreatitis After ERCP” that has been published in the recent issue of the Journal. The authors concluded that rectal indomethacin given right before endoscopic retrograde cholangiopancreatography (ERCP) can reduce the incidence and severity of post-ERCP pancreatitis (PEP). However, before incorporating this inexpensive, easily available nonsteroidal anti-inflammatory drug (NSAID) into our clinical practice for PEP prevention, several issues need further clarification: (a) It had been pointed out from a prospective large sample study that only individuals with serum amylase levels fivefold the normal upper limits and persistent pancreaticlike pain for 24 h after ERCP strongly suggest possibility of PEP (2); however, the authors stated that besides the 2-h measurement, serum amylase was repeated the next morning, and it is not clear what the exact time interval was. This may cast some doubt on the accuracy of the diagnosis of PEP in this study. (b) In the Methods section, the authors claimed subgroup analysis was used to evaluate the effect of indomethacin related to different variables. Notwithstanding, due to the lack of relevant information, it is not clear whether these subgroup analyses were ad hoc or post hoc. If these subgroup analyses were performed retrospectively, it should be considered as “fishing” for positive results, and the results from subgroup analyses should be treated with caution (3). (c) No explanation was provided as to why none of the sphincter of Oddi dysfunction (SOD) patients developed PEP, which is contrary to most other reported trials, with PEP incidence of up to 24% for patients with suspicious SOD (4). (d) They found that pancreatic duct injection, pancreatic duct cannulation more than once, and age less than 60 yr were significant risk factors for developing PEP. Certainly, it is convenient to perform a univariate analysis for exploration of each variable’s influence on the primary outcome; nonetheless, up to now, available evidence suggests that the incidence of PEP was not determined by any single factor. Thus, a multivariate statistical analysis with logistic regression allowing estimation of the influence of covariates on the incidence of PEP seems more appropriate. To summarize, this study suggests indomethacin may be an attractive pharmacotherapy for the prevention of PEP because it is inexpensive, universally available, and relatively safe. Clarification on some raised concerns will better our understanding of the mystery of PEP and its pharmacotherapy prevention. Yu Bai, M.D. Duowu Zou, M.D. Zhaoshen Li, M.D.
Certain Inflammatory Changes in Scabies Stressed Patients Treated with Permethrin 5%

The main manifestations of scabies disease are mediated through inflammatory and hypersensitivity like-reactions to mite products that lead to itching with different lesions. The initial inflammatory response is towards the mite and its products. The aim of this study is to Determinate certain inflammatory elements including eosinophil, CRP and ESR in Scabies patients (ordinary and Prisoners) treated with Permethrin 5%. The study included (28) Ordinary, (32) prisoners scabies patients as well as (30) healthy person as a control group. Determination of CRP was done by Ichroma, ESR by using (Mix RAT 20, VITAL) and Eosinophil count determined from complete blood count (CBC). The results showed that the level of CRP in sera of ordinary scabies patients was somewhat higher (non- significantly) as compared to prisoners (3.60±0.44 vs.2.75±0.35 mg/L), in pre-treatment stage, while in post-treatment, the levels were elevated in prisoners (non- significantly) as compared to ordinary scabies patients (3.57± 0.59 vs. 3.29±0.31mg/L) respectively. ESR levels were significantly increased in both patient groups (ordinary 25.68±2.97 and prisoners 25.34±0.77 mm/hr ) in comparison to control (8.0±1.06 mm/hr), but significantly decreased values (9.46±0.17 mm/hr) were recorded post-treatment in ordinary patients compared to that (19.78±0.17 mm/ hr) in prisoners. Eosinophil count in (ordinary and prisoners) groups of patients pre-treatment was significantly higher compared to control group (5.9±0.77, 5.2±0.5 and 2.2±0.17 cell/ µl ) respectively. , while a decreased mean values of ( 2.4 ±0.17 cell/ µl, 1.7 ±0.17cell/ µl ) were recorded in ordinary and prisoners patients post-treatment.
Fractional exhaled nitric oxide along with a reduced force expiratory volume are conclusive prognostic biomarkers to alert for asthma exacerbation

Background: Asthma is a multidimensional disease with noticeable heterogeneity in its presentation and reaction to treatment. Noninvasive biomarkers to determine disease progression are highly desirable. This study sought to identify fractional exhaled nitric oxide (FeNO), FeNO as a prognostic biomarker for asthma exacerbations, as well as a predictive biomarker for change in other known asthma indicators. Materials and Methods: A prospective, longitudinal study was conducted with a cohort of adult patients with severe asthma who required daily treatment with inhaled corticosteroids. Patients underwent lung function testing using spirometry, sputum samples were taken for inflammatory cell count, and sputum supernatant and exhaled respiration were taken for FeNO, FeNO measurement. Forced expiratory volume levels were measured, along with immunoglobulin E (IgE), eosinophil count, asthma-specific health-related quality of life, asthma-exact signs scores, and time to treatment failure. These indicators were measured over the 22-week study period. Results: A total of 1800 participants were recruited, 56.7% were female, and 70% of the participants were aged 18–27 years. FeNO was valuable prognostic biomarker for asthma exacerbations, along with forced expiratory volume in 1 s reduction. A greater quantity of eosinophils was correlated with a reduced risk of exacerbation in females, with no correlation in males. Elevated serum IgE levels were correlated with an increased risk of lung fibrosis. We found no significant relationships between the investigated indicators and hospitalization. Conclusion: FeNO, in conjunction with other biomarkers, is a useful prognostic indicator of exacerbations of symptoms in asthma patients.
A nomogram for predicting cancer-specific survival in different age groups for operable gastric cancer: a population-based study

Background The age thresholds for differentiating young and elderly patients are still under debate. This study aimed to evaluate the cut-off age for differentiating patients along with the prognostic value of age for operable gastric cancer (GC). Methods Patients diagnosed with resected gastric adenocarcinoma were identified from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database (training cohort and internal validation cohort) and Liaoning Cancer Hospital (external validation cohort). Kaplan-Meier plots were used to compare cancer-specific survival (CSS) across different age groups. Univariate and multivariate analysis was conducted using a Cox regression model. Predictive ability of the nomogram was determined by the Harrell’s concordance index (C-index), calibration curves, and Akaike’s Information Criterion (AIC). Results A total of 17,339 patients with GC were included. According to the univariate analysis results, CSS was similar among patients aged 20–69 years old, started to worsen for patients over the age of 70, and was the worst for patients older than 79 years in the training cohort. Thus, we further divided the age groups into 20–69, 70–79, and >79, and multivariate analysis showed that patients above 70 years of age had worse CSS. The nomogram was established based on the results of the multivariate analysis. The C-indexes for the training, internal, and external validation cohorts were 0.7531, 0.7344, and 0.7431, respectively. Conclusions This study showed that age had a relative predictive ability for CSS, 70 years should be the cut-off age, and age ≥70 years is an independent prognostic risk factor for GC patients who undergo surgery. These data highlight the importance of individualized treatment to improve the prognosis of patients with GC.
CYST, Comedones and Scarring Alopecia. what do they have to do with HIV disease?

XXXI Symposiumof the ISDP –Barcelona,October 21-23, 2010 ABSTRACTS (Posters and Oral Free Communications) CYST, Comedones and Scarring Alopecia. what do they have to do with HIV disease? Laila El Shabrawi-Caelen, Marisa André, Daisy Kopera. Dept. of Dermatology, Medical University Graz; Department of Dermatology, Hospital de Santa Maria. We describe a 52-year-old HIV-positive woman with a solitary patch of alopecia on her scalp. Clinically there was a pronounced loss of follicular orifices, multiple comedones and pustules. The patient also had acneiform lesions on her chest and axillae. Antiretroviral therapy with abacavir, darunavir and ritonavir was started two years before the development of the cutaneous symptoms. Histopathologic sections showed large infundibular cysts lined by a lichenoid lymphoplasmacellular infiltrate. Some of the infundibular cyst ruptured, eliciting a foreign body granulomatous reaction with calcification and ossification. With systemic retinoids and corticosteroids the cysts and comedones largely disappeared, leaving hyperpigmented macules and patches. There was no hair regrowth in scarred areas. We believe that these changes are best considered to be part of the so called HIV-associated follicular syndrome. The latter is an acneiform eruption in HIV patients, sometimes being associated with pityriasis rubra pilaris-like lesions and lichen spinulosus. The lesions typically involve the face and trunk. Involvement of the scalp with scarring alopecia is an unreported phenomenon. It is possible that the acneiform eruption in our patient occurred in the context of the highly active antiretroviraltherapy (HAART) and is part of the spectrum of the immune reconstitution inflammatory syndrome (IRIS). Epithelial Marker Expression in Metastatic Malignant Melanoma: A Pitfall in the Diagnosis of Cutaneous Myoepithelial Tumours
A discrete orthogonal polynomials approach for fractional optimal control problems with time delay

An efficient direct and numerical method has been proposed to approximate a solution of time-delay fractional optimal control problems. First, a class of discrete orthogonal polynomials, called Hahn polynomials, has been introduced and their properties are investigated. These properties are employed to derive a general formulation of their operational matrix of fractional integration, in the Riemann–Liouville sense. Then, the fractional derivative of the state function in the dynamic constraint of time-delay fractional optimal control problems is approximated by the Hahn polynomials with unknown coefficients. The operational matrix of fractional integration together with the dynamical constraints is used to approximate the control function directly as a function of the state function. Finally, these approximations were put in the performance index and necessary conditions for optimality transform the under consideration time-delay fractional optimal control problems into an algebraic system. Some illustrative examples are given and the obtained numerical results are compared with those previously published in the literature. AMS(2010): 34A08; 65M70; 33C45; 49J21.
ROLE OF CEO LEADERSHIP TOWARDS THE PERFORMANCE OF INDONESIAN SOES

The results of this study give us a big picture that the role of the leader in an organization is very important, including companies as large as the SOEs holding company. Companies that have good governance will have an impact on company performance directly and indirectly. Previous research has discussed a lot about leadership and corporate governance in certain companies, especially private companies, but very few studies of corporate governance and leadership have made the SOE holding company its object due to limited access and data. This research informs us that the transformation of CEO leadership and leadership style strategies has a direct and indirect influence on company performance following previous research conducted by several researchers such as Abdelrahman Zuraik, Louise Kelly (2018) and Ozer & Tinaztepe (2014 ). The results of the analysis of this study also found that innovative leadership did not have a significant effect on the performance of SOE holding companies. This was interesting because in several innovative leadership studies it had a significant influence on company performance, observing the condition of SOE holding companies that were governed by quite strict government regulations. thus making the leaders in the SOE holding company restricted to innovating too far from the rules set by the government in terms of policy, but when mediated by organizational identification and the involvement of innovative leadership work has a significant influence in accordance with previous information that the organization in the SOEs holding company has a stronger factor compared to leadership, this is also in accordance with previous research conducted by Wang et al. (2017) Buil et al. (2019) and Soarez & Masquera (2019) who got the same results both in the form of the influence of organizational identification and direct work involvement on company performance.
Risks and Benefits of Web-Based Patient Narratives: Systematic Review

Background Patient narratives are illustrative, individual accounts of patients’ experiences with certain health conditions. Web-based patient narratives have become widely available on the internet and in social media, as part of electronically available patient decision aids or Web-based databases. In recent years, the role of patient narratives as a source of information, insight, and support for both health care users and providers has increasingly been emphasized. Although the potential impact of patient stories has high immediate plausibility, it is of interest to know if this impact can be captured in quantitative studies. Objective This review aimed to evaluate whether research-generated Web-based patient narratives have quantifiable risks or benefits for (potential) patients, relatives, or health care professionals. Methods We searched the following databases from August 2017 to March 2019: Medical Literature Analysis and Retrieval System Online, PsycInfo, Sociological Abstracts, Web of Science, and EMBASE. Titles and abstracts of the retrieved studies were reviewed and assessed for the inclusion and exclusion criteria. Papers were included if they studied the following: (1) (potential) patients, relatives, or health care professionals; (2) the effects of Web-based patient narratives that were generated scientifically (eg, through qualitative research methods); and (3) were quantitative studies. Furthermore, 2 authors independently performed an assessment of the quality of the included studies using a validated checklist. Results Of 4226 documents, 17 studies met the inclusion criteria. The studies investigated 10 different sources of Web-based patient narratives. Sample sizes ranged from 23 to 2458. The mean score of the quality assessment was 82.6 (range 61-100). Effects regarding five different purposes were identified as follows: provide information, engage, model behavior, persuade, and comfort. We found positive effects in every category and negative effects in one category (persuade). Several of the reported effects are rather small or were identified under specific experimental conditions. Conclusions Patient narratives seem to be a promising means to support users in improving their understanding of certain health conditions and possibly to provide emotional support and have an impact on behavioral changes. There is limited evidence for beneficial effects on some outcomes. However, narratives are characterized by considerable heterogeneity and the investigated outcomes are hardly comparable with each other, which makes the overall judgment difficult. As there are numerous possible measures and purposes of narratives, quantifying the impact of Web-based patient narratives remains a challenge. Future research is needed to define the optimal standards for quantitative approaches to narrative-based interventions.
Knowledge, Attitude, Practices, and Factors Associated with Voluntary Blood Donation among Graduating Class Students of Assosa University, Benishangul Gumuz, Ethiopia, 2018

Background: Blood transfusion is a vital therapeutic approach in modern health care that saves millions of lives, but there is a great challenge to gate sufficient voluntary blood donation in developing country like Ethiopia at the same time pregnancy and child birth related problem, rod traffic accident, malaria-related death is high. Methods: Institutional based cross-sectional quantitative study was used from April 27 to May 11, 2018 and data was collected using a self-administered questionnaire. A stratified sampling method was used and an individual was selected by simple random sampling within each stratum. EPI data version 3.02 for data entry and SPSS version 16 for analysis was used both bi-variant and multivariant analysis was computed and significance was declared at AOR<0.05. Result: From the total study participants, 162 (48.5%) had adequate knowledge, 230 (68.9%) of the respondent had favorable attitudes towards blood donation whereas only 85 (25.4%) have ever donated blood in their lifetime. Having inadequate knowledge 3.118 times more likely non-donors (AOR=3.118: 1.775, 5.479) than compared to those having adequate knowledge, and unfavorable attitude 4.254 times non-donors (AOR=4.254% CI: 1.996, 9.069) than compared to those having a favorable attitude. Whereas being a user of television 2.015 times more likely non-donors of blood (AOR=2.015% CI: 1.100, 3.690) than compared to non-user. Conclusion: The result shows that there was poor habit of blood donation practice among students and even from donors above the mean range 57.6% of respondent donate blood to help relatives or friends and we recommend further study in this area, to give training for blood bank service workers and organize motivational blood donor club to utilize potential voluntary blood donors.
INTRA-AXONAL TRANSPORT OF CLATHRIN AND ACTIN

Polypeptides in the retinal ganglion cells of the adult rats were labelled with [358]methionine, and radioactive polypeptides migrating in the optic nerve and tract were analysed by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis and fiuorography. A group of polypeptides were found to migrate at an average velocity of 1.8 mm/day, among which a 175K polypeptide was identified as clathrin based on its molecular weight, copurification with brain coated vesicles, solubility properties in various media, and on the reconstitution experiment after dissociation of coated vesicles in urea. Acting was seen to migrate in the rat optic axons at an average velocity of 0.7 mm/day, suggesting that clathrin and actin are not primarily associated during their migration towards the nerve terminals. Separate axonal transport of clathrin, vesicular membrane components and actin, and their possible reorganisation in nerve terminals are discussed.