Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of dairy and supplemental calcium on food intakes in a group of Jordanian females

Objective. The effect of calcium intervention equivalent to three cups of milk/ day from dairy foods and 800 mg supplemental calcium as tablets, compared to a control group on normal diets with one cup of milk/ day, was studied on food and nutrient intakes. Methods. A group of 122 healthy adult Jordanian females, age 20-45 years, were recruited in the study during a period of 12 weeks. Study sample was divided into: dairy calcium group, supplemental calcium group, and control group. Intakes of main food groups, energy, carbohydrates, protein, fat, cholesterol, dietary fiber, calcium and vitamin D were evaluated, and their intake adequacies were assessed using the dietary reference intakes (DRIs) and food exchange system at the end of the study. Results. highly significant differences (P 0.05) were obtained between the different treatment groups regarding their intakes of fruits and vegetables. As for energy intakes, the control group exhibited a significantly (p <0.05) higher contribution of energy intake compared to the other intervention supplemented groups. Conclusions. It can be concluded that the postulation that the favorable effects of dairy components on food intake, subjective satiety and intake regulatory mechanisms have been usually observed in short term experiments where the components were consumed in amounts that found in usual serving sizes of dairy products, and in the current study, the milk intake of the milk group seemed to affect satiety and eating pattern of diet and nutrient intakes by lowering food and energy intakes.
Incidence and Risk Factors of HIV-1 Infections among Pregnant Women in Burkina Faso from 2012 to 2016

Background: New cases of HIV/AIDS are still being reported and threaten the achievement of the HIV-1 elimination goal in Burkina Faso. An adequate assessment of the extent of this problem is key to redistributing available resources. HIV-1 incidence and associated risk factors among pregnant women estimated in Burkina Faso. Materials and Methods: We conducted a cross-sectional survey of pregnant women in all 13 administrative regions of Burkina Faso from 2012 to 2016. Collected sera analyzed by Vironostika HIV Uniform II Plus O, ImmunoComb II HIV-1 & 2 Bispot, HIV BLOT 2.2 assays to determine serological status. HIV-1 LAg-Avidity EIA performed on HIV-1 positive samples to differentiate between recent and old infections. Sociodemographic information collected for all participants. Data analysis performed using EPI Info and XLSTAT. Results: A total of 36,848 pregnant women included in the analyses. Serological testing showed 483 HIV-1 positive, 18 HIV-2 positive, 7 HIV-1 + 2 coinfection cases. Overall, 355 HIV-1 positive samples tested with HIV-1 LAg-Avidity EIA; the remaining samples had insufficient volume to be tested. The adjusted incidence rates were 0.17% and 0.09% (p=0.0919) in 2015 and 2016, respectively. Sociodemographic factors associated with recent infections included the 25-34 and ≥35 year age groups, high education level, household and secretary occupations, trader wife, civil servant wife, residence in urban sites, being married, a length of stay in the administrative region of <1 year. Conclusion: HIV-1 incidence is decreasing in Burkina Faso. However, women with certain risk factors should be targeted in prevention programs to reach the country’s HIV-1 elimination goal.
Comparison of carbetocin with other uterotonic agents in preventing postpartum hemorrhage

Postpartum hemorrhage (PPH) is defined as blood loss of at least 500 ml or more after vaginal delivery and 1000 ml or more after abdominal delivery. It contributes up to 28% of maternal mortality worldwide and 30.3% of maternal death in Indonesia. 70% cases of PPH are caused by uterine atony. PPH can be prevented by doing routine use of uterotonic agents in active management of third stage of labour. Uterotonic agents that currently available are oxytocin, carbetocin, methylergometrine, syntometrine, misoprostol and carboprost. Carbetocin (a long-acting synthetic analogue of oxytocin) is a new drug which has stronger ability to induce uterine contraction than oxytocin. It does not induce hypertension like methylergometrine and syntometrine. Therefore, carbetocin can be considered as an alternative drug to oxytocin in women with severe preeclampsia. However, more studies are needed to assess the efficacy and safety of carbetocin for prevention of PPH in preeclamptic women. Compared to methylergometrine and syntometrine, carbetocin is more effective in reducing postpartum blood loss. Adverse effects like nausea and vomiting were lower in women treated with carbetocin. Compared to misoprostol, carbetocin is also superior in reducing blood loss. Adverse effects like shivering, fever and metallic taste were higher in women treated with misoprostol. Further studies are needed to assess the superiority between carbetocin and carboprost since there is no published literature yet regarding this topic. In conclusion, carbetocin is superior to other uterotonic agents in preventing postpartum hemorrhage with fewer adverse effects.
Ruff guide to the politics of PE & School Sport

The belief in the capacity of sport to positively develop both the individual and society has not been lost on UK governments. Most recently the thoughts, words and actions which comprise sport policy in the UK have focused on young people (Collins, 2010). The statutory requirement to attend school between the ages of 5 and 16 years, has afforded policy-makers the opportunity to shape the initial experiences of this priority and 'captive' group with the intention of encouraging habitual, lifelong participation in sport and physical activity through and beyond the school and extra-curriculum (Cale, 2000; Houlihan, 2000; Roberts, 1996).
Genetic Architecture of Vitamin B12 and Folate Levels Uncovered Applying Deeply Sequenced Large Datasets

Genome-wide association studies have mainly relied on common HapMap sequence variations. Recently, sequencing approaches have allowed analysis of low frequency and rare variants in conjunction with common variants, thereby improving the search for functional variants and thus the understanding of the underlying biology of human traits and diseases. Here, we used a large Icelandic whole genome sequence dataset combined with Danish exome sequence data to gain insight into the genetic architecture of serum levels of vitamin B12 (B12) and folate. Up to 22.9 million sequence variants were analyzed in combined samples of 45,576 and 37,341 individuals with serum B12 and folate measurements, respectively. We found six novel loci associating with serum B12 (CD320, TCN2, ABCD4, MMAA, MMACHC) or folate levels (FOLR3) and confirmed seven loci for these traits (TCN1, FUT6, FUT2, CUBN, CLYBL, MUT, MTHFR). Conditional analyses established that four loci contain additional independent signals. Interestingly, 13 of the 18 identified variants were coding and 11 of the 13 target genes have known functions related to B12 and folate pathways. Contrary to epidemiological studies we did not find consistent association of the variants with cardiovascular diseases, cancers or Alzheimer's disease although some variants demonstrated pleiotropic effects. Although to some degree impeded by low statistical power for some of these conditions, these data suggest that sequence variants that contribute to the population diversity in serum B12 or folate levels do not modify the risk of developing these conditions. Yet, the study demonstrates the value of combining whole genome and exome sequencing approaches to ascertain the genetic and molecular architectures underlying quantitative trait associations.
A RESEARCH NOTE ON ORGANIZING REGULATION IN A MULTI-ACTOR SETTING

In recent years, the regulation literature has reported the rise of the regulatory state, which has two central features. First, regulatory bodies operate in complex fragmented constellations. Previous research focused on describing such constellations in specific sectors. A second feature is that sectoral regulators have been established with some autonomy from their minister. Previous studies have focused largely on the extent to which agencies are formally independent from politicians and regulatees. The main argument of my study is that the regulation literature has produced a partial picture of the autonomy of regulators. First, a focus on formal autonomy alone ignores that the actual autonomy may differ significantly from the formal autonomy. Second, whereas the regulation literature has mostly focused on the autonomy from political principals on the one hand and from the regulated industry on the other, the literature on interorganizational relations suggests that the constellation, of which a specific sectoral regulator is only one member, may affect the autonomy of specific regulators as well.
Food Restriction and Sperm Number in the Water Strider Aquarius remigis.

Male Aquarius remigis (Hemiptera: Gerridae), produce giant sperm with an unusual morphology: unlike most animal sperm, in which the length of the tail far exceeds that of the head, the heads and tails of A. remigis sperm are approximately equal in length. The acrosome of A. remigis sperm contains a matrix rich in flavin adenine dinucleotide (FAD), a riboflavin-containing molecule. Previous studies have shown that giant sperm are costly to produce, leading to a trade-off between sperm size and number. Furthermore, insects are unable to synthesize riboflavin and must obtain it through their diet; given their FAD-rich sperm, A. remigis males likely require large amounts of dietary riboflavin for sperm production. Thus, given their large, costly, nutrient-rich gametes, I hypothesized that male A. remigis would respond to food restriction with a decrease in sperm number. Here, I tested the hypothesis that sperm number, and hence male fertility, is limited by food availability in A. remigis with a series of four studies examining (1) sperm numbers and egg fertility in wild males and females in natural populations, (2) the effect of food restriction on sperm number and mating behavior in wild-caught males, (3) the effect of food restriction on sperm number and mating behavior in lab-reared males, and (4) long-term sperm storage in females.I found that males and females in natural populations often contain few or no sperm, and the fitness of both sexes may, at times, be limited by sperm supplies. Food restriction had a drastic effect on sperm numbers in wild males, with fed males containing much more sperm than unfed males. Mating behavior was also subject to the effects of food restriction, with fed males mating more frequently than unfed males. No such effect of food restriction was seen on sperm numbers or mating behavior in males reared in the laboratory with abundant food. Finally, I found that viable sperm can be stored in the female reproductive tract for at least seven weeks, which is even longer than previously known.
Commuter Students’ Educational Experiences and Sense of Belonging in the Undergraduate Engineering Community: A Phenomenological Study

The purpose of this study is to describe the “lived experience” of commuter students attending an urban institution. Participants were 28 ethnically diverse students who commuted more than 15 minutes each way to campus. We employed Astin’s Input-Environment-Outcome (I-E-O) model as the conceptual framework to investigate commuter students’ sense of belonging within the undergraduate engineering community. Interview transcripts were analyzed using Creswell’s phenomenological research methodology. Four common themes or “clusters of meaning” were found to play an important role in the development or hindrance of participants’ sense of belonging in engineering. These themes were integrated into the phenomenological “essence” of the participants’ experiences. In this paper, we also offer implications for practice for the Engineering Educator of 2016 by including suggestions based on these results which may help minimize potential delays in commuter students’ sense of belonging and promote integration into the undergraduate engineering community.
A Comparison of Fractal Dimension Algorithms by Hurst Exponent using Gold Price Time Series

Fractal approach is a suitable method for the analysis of the complex time series. The Fractal dimension is the measure of complexity and the chaotic behaviours of the fractal time series. A variety of algorithms are existing for the computation of Fractal dimension. In this study, the most common methods of estimating Fractal dimension of financial time series are analyzed and compared. The analysis is performed over the gold price data. Fractal dimension through the Hurst exponent is estimated to provide effective and efficient understanding of the characteristics of the financial time series. In this paper the Fractal dimension is calculated from Hurst exponent by the methods the Rescaled range analysis(R/S analysis) and the Detrended fluctuation analysis (DFA). The Time series is analyzed and the comparison between the Fractal dimension algorithms by the Rescaled range analysis and the Detrended fluctuation analysis is established. The obtained results show that the long memory phenomenon is present and the time series is persistent.
International Journal of Biopharmaceutics

Malaria, Enteric fever and Dengue still remain diseases of major public health importance in tropics. The individuals from endemic areas and also these three infections are classified under pyrexia of unknown origin (PUO). Laboratory diagnosis of Malaria, Enteric fever and Dengue infections by utilizing Peripheral Smear (PS), Slide agglutination test (WIDAL) and Rapid immunochromatography test (NS1R-ICT) respectively in PUO cases. Material and The laboratory records of clinically suspected PUO cases from January to August 2014 were analyzed retrospectively and tests were performed by following the manufacturer’s instructions. Result: In the present study the majority of PUO cases are diagnosed as Dengue (23.33%) followed by Enteric fever (12.63%) and Malaria (0.47%). These tests should be a useful aid in confirming the clinical diagnosis of PUO. The WIDAL test has significant role in pyrexia evaluation. Both Malaria and Dengue could be controlled by vector (Mosquitoes) with good personal and environmental hygiene.
Evolutionary algorithm for multi-objective multi-index transportation problem under fuzziness

An Improved Genetic Algorithm (I-GA) for solving multi-objective Fuzzy Multi–Index Multi-objective Transportation Problem (FM-MOTP) is presented. Firstly, we introduce a new structure for the individual to be able to represent all possible feasible solutions. In addition, in order to keep the feasibility of the chromosome, a criterion of the feasibility was designed. Based on this criterion, the crossover and mutation were modified and implemented to generate feasible chromosomes. Secondly, an external archive of Pareto optimal solutions is used, which best conform a Pareto front. For avoiding an overwhelming number of solutions, the algorithm has a finite-sized archive of non-dominated solutions, which is updated iteratively at the presence of new solutions. Finally, the computational studies using two numerical problems, taken from the literature, demonstrate the effectiveness of the proposed algorithm to solve FM-MOTP Problem under fuzziness.
Slow-Time MIMO-FMCW Automotive Radar Detection with Imperfect Waveform Separation

This paper considers object detection in the case of imperfect waveform separation, in the context of automotive radars with a slow-time MIMO-FMCW signaling scheme. We develop an explicit signal model that accounts for waveform separation residuals and propose a Kronecker subspace-based object detector in the framework of generalized likelihood ratio test (GLRT). Our exact theoretical analysis under both hypotheses shows that the proposed detector holds the desired property of constant false alarm rate (CFAR). Numerical simulations validate our proposed object detection scheme.
Pan-African Genetic Structure in the African Buffalo (Syncerus caffer): Investigating Intraspecific Divergence

The African buffalo (Syncerus caffer) exhibits extreme morphological variability, which has led to controversies about the validity and taxonomic status of the various recognized subspecies. The present study aims to clarify these by inferring the pan-African spatial distribution of genetic diversity, using a comprehensive set of mitochondrial D-loop sequences from across the entire range of the species. All analyses converged on the existence of two distinct lineages, corresponding to a group encompassing West and Central African populations and a group encompassing East and Southern African populations. The former is currently assigned to two to three subspecies (S. c. nanus, S. c. brachyceros, S. c. aequinoctialis) and the latter to a separate subspecies (S. c. caffer). Forty-two per cent of the total amount of genetic diversity is explained by the between-lineage component, with one to seventeen female migrants per generation inferred as consistent with the isolation-with-migration model. The two lineages diverged between 145 000 to 449 000 years ago, with strong indications for a population expansion in both lineages, as revealed by coalescent-based analyses, summary statistics and a star-like topology of the haplotype network for the S. c. caffer lineage. A Bayesian analysis identified the most probable historical migration routes, with the Cape buffalo undertaking successive colonization events from Eastern toward Southern Africa. Furthermore, our analyses indicate that, in the West-Central African lineage, the forest ecophenotype may be a derived form of the savanna ecophenotype and not vice versa, as has previously been proposed. The African buffalo most likely expanded and diverged in the late to middle Pleistocene from an ancestral population located around the current-day Central African Republic, adapting morphologically to colonize new habitats, hence developing the variety of ecophenotypes observed today.
Effect of Dividend Announcement on Stock Prices in Banking Industry of Pakistan

This paper proves the result of change in dividend on the stock price. The sample of the population depends on the three banking sector of Pakistan which is Bank Al-Falah, UBL and MCB. In this paper descriptive data was gathered of the five years (2008-2012) related the Banking sectors of the payment of dividend and stock price. The descriptive statistics and regression analysis represent that there is positive or negative relationship has been found between the dividend and stock price. It is proved that the dividend has positive regression with the earning per share and negative regression dividend with the stock price.
Preserving peer replicas by rate-limited sampled voting

The LOCKSS project has developed and deployed in a world-wide test a peer-to-peer system for preserving access to journals and other archival information published on the Web. It consists of a large number of independent, low-cost, persistent web caches that cooperate to detect and repair damage to their content by voting in "opinion polls. " Based on this experience, we present a design for and simulations of a novel protocol for voting in systems of this kind. It incorporates rate limitation and intrusion detection to ensure that even some very powerful adversaries attacking over many years have only a small probability of causing irrecoverable damage before being detected.
Empirical Bernstein stopping

Sampling is a popular way of scaling up machine learning algorithms to large datasets. The question often is how many samples are needed. Adaptive stopping algorithms monitor the performance in an online fashion and they can stop early, saving valuable resources. We consider problems where probabilistic guarantees are desired and demonstrate how recently-introduced empirical Bernstein bounds can be used to design stopping rules that are efficient. We provide upper bounds on the sample complexity of the new rules, as well as empirical results on model selection and boosting in the filtering setting.
University of Southern Denmark Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas Barros-Filho,

Citation for pulished version (APA): Barros-Filho, M. C. , Reis-Rosa, L. A. , Hatakeyama, M. , Marchi, F. A. , Chulam, T. , Scapulatempo-Neto, C. , Nicolau, U. R. , Carvalho, A. L. , Pinto, C. A. L. , Drigo, S. A. , Kowalski, L. P., & Rogatto, S. R. (2018). Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas. Oral Oncology, 83, 81-90. https://doi.org/10.1016/j.oraloncology. 2018.06. 010
NKTR-214 (CD122-biased agonist) plus nivolumab in patients with advanced solid tumors: Preliminary phase 1/2 results of PIVOT.

3006Background: PIVOT is an ongoing, open-label, phase 1/2 study of NKTR-214 (214; CD122-biased agonist) plus PD-1 inhibitor nivolumab (N) in patients (pts) with advanced cancers (MEL, RCC, NSCLC, TNBC, and UC). 214 monotherapy increases newly proliferative CD8+ T cells in tumors and increases cell surface PD-1 and PD-L1 expression, demonstrating a potentially synergistic mechanism with anti-PD-1 therapy. Methods: In P1 dose escalation, pts received 214 (0.003, 0.006 or 0.009 mg/kg) with N (240 mg or 360 mg) administered IV as outpatient Q2W or Q3W; in P2 expansion, the RP2D of 214 (0.006 mg/kg) with N (360 mg) Q3W was administered concurrently. Response was assessed Q8W by RECIST v1.1. Matched tumor samples were evaluated for changes from baseline in immune cell populations, gene expression, and T cell receptor repertoire. Tumor baseline and on treatment PD-L1 protein expression was assessed (28-8 IHC assay). Results: As of 7FEB2018, 162 pts (P1, n = 38; P2, n = 124) were evaluable for safety. The most c.