Miracle-dz/UniFAR-FTUs huggingface dataset:
The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer

Abstract Triple-negative breast cancer (TNBC) is a special subtype of breast cancer, accounting for 10–20% of breast cancers with high intrinsic heterogeneity. Its unique immune microenvironment, including high expression of vascular endothelial growth factors, tumor infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and other molecules that promote the growth and migration of tumor cells, has been shown to play a dual role in the occurrence, growth, and metastasis of TNBC. Understanding the TNBC microenvironment is of great significance for the prognosis and treatment of TNBC. In this article, we describe the composition and function of immune cells in the TNBC microenvironment and summarize the major cytokine growth factors and chemokines in the TNBC microenvironment. Finally, we discuss the progress of TNBC, cytokine-induced killer cell therapy, and immune checkpoint therapy.
Does Gender Difference Exist in Typologies of Intergenerational Relations? Adult Son-Parent and Daughter-Parent Relations in Hong Kong

This study examines the typologies of adult son–parent and daughter–parent relations in Hong Kong, a place where East meets West. The data were drawn from a survey of 834 adult children (381 sons and 453 daughters) aged between 18 and 59 with at least one living parent. Latent class analysis identified four types of relations for both son-parent and daughter-parent relations: tight-knit, distant ascending ties, obligatory, and detached. Sons were more likely to engage in obligatory and tight-knit relations with parents, whereas daughters were more likely to engage in distant ascending ties relations. Multinomial logistic regression found that adult children who were young, single, or co-residing with their child aged above 18 were more likely to have tight-knit relations with their elderly parents. Our findings suggest that although the male-dominated norm remains influential in Hong Kong, daughters are increasingly maintaining close interactions with their parents.
A Study of the Impact of Value-Added Efficiency on Profitability and Market Value in the Indian Pharma Industry

The aim of this paper is to highlight the growing influence of Intellectual Capital (IC) on the profitability and market valuation, especially in knowledge-based industries. The scope of this paper is restricted to the Indian Pharmaceutical Industry, which is highly dependent on IC. This study employs the measure of Value-Added Intellectual Coefficient (VAIC) to assess impact of IC on the profitability and market valuation and to assess the growth of VAIC and its components among the companies over the years selected for the study. The study uses 22 Pharmaceutical companies listed in the Bombay Stock Exchange for a period of 12 years from the financial year 2008-09 to 2019-20. By using Path Analysis, the study demonstrates that the components of VAIC have an impact on the ROCE and market value, which has only grown as compared to earlier studies & years. The study also demonstrates that high sales and profits need not necessarily result in high VAIC. Received: 7 October 2021 / Accepted: 24 November 2021 / Published: 3 January 2022
Revisited The Importance and Performance Analysis (IPA) and Kano Model for Customer Satisfaction Measurement

This study is to find out what the result of qualitative and quantitative approaches related to customer satisfaction if its measurement is carried out by integrating the measurement of customer satisfaction refers to the importance-performance (IPA) concept and Kano model into SERVQUAL attributes format. By considering the attributes aspects of SERVQUAL related to criteria of quality service with a case in education institution, the survey using questionnaires developed on the importance-satisfaction analysis (IPA) of 5 point of Likert scale were then performed in order to investigate the current of satisfaction condition. While the Kano criteria associated to the dichotomous statements contain of functional and dysfunctional of quality attributes level were then used to quantify the qualitative response. In this study, the domain of functional and dysfunctional of Kano is discussed and reviewed, including how their correlation against IPA and vice versa. By integrating of both approaches, the correlation between both will represent each of their characteristics as to be compared to each other, in which the result can be justified as the priorities of customer satisfaction. In addition, the consistencies of response data based on the approaches related to the criteria of KANO diagram against the functional and dysfunctional element can be defined in order to characterize the background and types of survey questionnaires
The Degree of Application of Educational Administrative Accountability by the Principals of Special Education Centers and its Relationship to Some Variables from Teachers’ Perspective

This study aimed to define the degree of application of educational administrative accountability by the principals of special education centers and its relationship to some variables from the teachers' perspective in Amman. The descriptive-analytical approach was adopted. The study sample consisted of (85) male and female teachers, who were chosen randomly. A measure of administrative accountability in educational systems was developed consisting of four areas namely, students, teachers, goals, innovation, and creativity. Findings revealed that the degree of application of educational administrative accountability by the principals of special education centers came to a medium degree and in all its fields, and there were no differences in the degree of application of educational administrative accountability by the principal of special education centers attributed to the variables of gender and educational level. Received: 23 September 2021 / Accepted: 15 November 2021 / Published: 3 January 2022
Disturbance and valley confinement: Controls on floodplain large wood and organic matter jam deposition in the Colorado Front Range, USA

Organic matter dynamics (entrainment, transport, deposition) can influence ecogeomorphic complexity in rivers. However, the depositional controls on downed large wood (LW) and coarse particulate organic matter (CPOM) on floodplains have rarely been assessed. We investigate the influence of different disturbance histories, as well as geomorphology and forest stand density, on the deposition of LW and CPOM accumulations, or jams, between two adjacent drainages (West Creek, North Fork Big Thompson) in the semi‐arid Colorado Front Range, USA. Both basins recently experienced an extreme flood, but West Creek experienced a larger flood peak as well as a recent upstream fire. We also analyse jam fabric (LW piece orientation) between floodplain and in‐channel jam types. We measured LW and CPOM jams on the North Fork to compute jam frequencies (jams ha−1) and loads (volume per area; m3 ha−1), and we compare these data to a previously published dataset from West Creek. Average floodplain LW jam frequencies (70.4 jams ha−1) and loads (678.6 m3 ha−1) on West Creek were significantly higher than on the North Fork (frequency: 14.8 jams ha−1; load: 94.3 m3 ha−1). Average floodplain CPOM jam frequencies (West Creek: 19.0 jams ha−1; North Fork: 15.1 jams ha−1) and loads (West Creek: 10.70 m3 ha−1; North Fork: 9.98 m3 ha−1) were not significantly different between basins. A larger flood peak, likely enhanced by a recent upstream fire and a more confined valley bottom, resulted in greater deposition of LW jams on West Creek compared to the North Fork. Geomorphic characteristics, such as valley confinement and slope, also influence jam frequencies and loads. Floodplain jam types oriented parallel to the stream were significantly different than other jam types. This work will inform river restoration efforts using wood and organic matter and provide insight on the transport and depositional processes influencing floodplain LW jam formation.
Design and Analysis of a Simple Miniaturized Fractal Antenna for 5G Ka-Band Applications

This paper presents the design and analysis of a simple geometry ultra-wideband antenna for 5G Ka-band applications. The antenna is inspired from a T-shaped microstrip antenna. Initially consecutive iterations were performed to design a wideband antenna using T-shaped fractals. Afterwards, various performance parameters including impedance bandwidth, radiation pattern and gain was improved by optimizing the shape and various lengths of the antenna. The proposed work offers an ultra-wideband range of 25 – 39.2 GHz covering > 97% of Ka-band, having broadside radiation pattern with high gain between 6–10 dBi. The antenna offers a compact size of 15×15×1.524 mm3 and high overall performance as compared to the recently reported work for similar applications. The design and analysis of the proposed work were performed using High Frequency Structural Simulator (HFSS).
The effectiveness of policy communication in promoting #KangPisMan program among university students

This study is aimed at measuring the effectiveness of policy communication in promoting #KangPisMan program among university students. #KangPisMan is a top priority program of Bandung Municipal Government to tackle waste management problem. In this sense, the problem of plastic waste has become a global concern about environment, therefore it is a hope that, by promoting #KangPisMan, a new lifestyle will make people more aware of environmental sustainability. The program was established in 2018, so it is necessary to measure the effectiveness of its communicating strategy. In terms of public communication, the realization of promoting the program should be measured based on its optimal value. The present study seeks to analyse the effectiveness of communication strategy by employing 7C concepts as introduced. The questionnaire was distributed to 300 respondents (based on purposive sampling) which were registered as students of Faculty of Social Sciences Education, Universitas Pendidikan Indonesia. Validity of the questionnaire is measured by corrected item-total correlation. The analysis shows that communication strategy in promoting #KangPisMan was relatively effective by considering the lowest scores of continuity and consistency. It shows that the aspect of consistency in promoting the program should be enhanced. Meanwhile, the aspect of credibility had the highest value. Therefore, it is a big capital to promote the program through the role model as reflected by the team. In general, all respondents were satisfied of the communication strategy in promoting the program. However, the effectiveness is still potential to be developed in the upcoming time.
The Effects of User Generated Content and Firm Generated Content on Millennials’ Purchase Intention of Shariah-Compliant Stocks

The goal of this study is to understand how digital content marketing influences online share purchase intentions. The specific objective of this study is to determine the effect of user generated content and firm generated content on millennials’ purchase intention of online shares. The data for this study were collected using a convenience sampling approach from 308 valid online questionnaires in Malaysia and analysed using the partial least squares structural equation modelling technique (PLS-SEM). According to the findings of this study, both user-generated and firm-generated contents have a positive impact on brand attitude. The results of applying the theory of reasoned action revealed a counterintuitive result to earlier research whereby user generated content has no direct effect on the purchase intention of online stocks. Theoretical and managerial implications of financial marketing are discussed.
Comparison of the hydrocolloids application efficiency for stabilizing the foam of beer

Subject of research: technology of high gravity brewing, developed to improve production efficiency and reduce energy consumption. This technology has a wide range of benefits, from improving process economics to reducing environmental impact. Investigated problem: despite the presence of significant advantages, there are a number of problems in the technology of high gravity brewing that need to be solved. The main problem is to reduce the foam stability of the resulting beer, which, together with the appearance, aroma and taste, is the most important attributes of the quality of the beverage for the consumer. The stability and texture of the foam depend, among other things, on the quality of grain and hop raw materials, and the course of technological processes. Elevated levels of key malt proteins (LTP1, Z4 and Z7) and hop α-acids have a positive effect on foam quality. Yeast protease A has a negative effect. Yeast secretes this enzyme to a greater extent during fermentation of high gravity wort, which may be one of the reasons for the decrease in foam stability in high gravity brewing. High molecular weight a- and b-glucans with hydrophilic properties can play an important role in foam stabilization. They increase the viscosity of the liquid, slow down its drainage from the foam segments and thereby increase the foam retention. Main scientific results: the effect of hydrocolloids (highly methoxylated pectin, carboxymethyl cellulose, xanthan gum, guar gum, a mixture of xanthan and guar gum) on foam performance and beer filtration rate was investigated. The advantages of pectin as an additive allowing to stabilize beer foam, in particular, in high gravity - brewing, have been established. The recommended dosage of the additive is 0.4-1 g/hl. Highly methoxylated pectin is a good alternative to the currently widespread use of propylene glycol alginate. The area of practical implementation of the research results: brewing companies. Innovative technological product: highly methoxylated pectin as a stabilizing additive for beer foam. Scope of application of the innovative technological product: the use of highly methoxylated pectin as additives that stabilize beer foam, in particular in high gravity brewing.
The predictive value of resting heart rate in identifying undiagnosed diabetes in Korean adults: Korea National Health and Nutrition Examination Survey

OBJECTIVES The purpose of this study was (1) to examine whether the addition of resting heart rate (RHR) to the existing undiagnosed diabetes mellitus (UnDM) prediction model would improve predictability, and (2) to develop and validate UnDM prediction models by using only easily assessable variables such as gender, RHR, age, and waist circumference (WC). METHODS Korea National Health and Nutrition Examination Survey (KNHANES) 2010, 2012, 2014, 2016 data were used to develop the model (model building set, n=19,675), while the data from 2011, 2013, 2015, 2017 were used to validate the model (validation set, n=19,917). UnDM was defined as a fasting glucose level ≥126 mg/dL or glycated hemoglobin ≥6.5%; however, doctors have not diagnosed it. Statistical package for the social sciences logistic regression analysis was used to determine the predictors of UnDM. RESULTS RHR, age, and WC were associated with UnDM. When RHR was added to the existing model, sensitivity was reduced (86 vs. 73%), specificity was increased (49 vs. 65%), and a higher Youden index (35 vs. 38) was expressed. When only gender, RHR, age, and WC were used in the model, a sensitivity, specificity, and Youden index of 70%, 67%, and 37, respectively, were observed. CONCLUSIONS Adding RHR to the existing UnDM prediction model improved specificity and the Youden index. Furthermore, when the prediction model only used gender, RHR, age, and WC, the outcomes were not inferior to those of the existing prediction model.
DC-only Apodisation of Fibre Bragg Gratings

We show how a simple apodisation technique can be used to suppress side modes in fibre Bragg gratings. The technique recognises that these side modes arise from Fresnel reflections off the ends of the grating and can be reduced by simply tapering the dc-only component just beyond the ends of the grating. To this end the profile of the writing beams are altered using lens aberration, correspondingly smoothing the index modulation envelope and reducing reflections off the grating ends. This differs from conventional apodisation where the modulation depth of the induced refractive index is tapered appropriately.
Manfaat Permainan Tradisional Engklek dalam Aspek Motorik Kasar Anak

Anak yang mengalami kesulitan dalam melakukan koordinasi antara gerakan visual (pandangan mata) dan motorik (gerakan tangan, gerakan jari tangan atau kaki) secara serempak pada tujuan. Hal tersebut disebabkan karena lemahnya kordinasi gerak visual motoric. Permainan tradisional engklek untuk anak adalah permainan yang menyenangkan. Permainan engklek biasanya dimainkan oleh 4 sampai 6 orang. Melalui permainan ini anak dapat belajar disiplin, tanggung jawab dan bekerjasama. Banyak sebagian orang yang tidak mengetahui manfaat permainan tradisional engklek bagi aspek motorik kasar anak padahal manfaat permainan tradisional engklek itu tidak hanya bagi kesehatan saja tetapi salah satunya motorik kasarnya juga ada. Tujuan dari penelitian ini untuk mengetahui lebih dalam manfaat permainan tradisional engklek dalam aspek motorik kasar pada anak. Desain dalam penelitian merupakan desain penelitian kualitatif dengan menggunakan metode Deskriptif. Teknik pengumpulan data ini menggunakan wawancara, observasi dan dokumentasi. Teknik observasi hanya mengamati dan melihat anak yang sedang melakukan permainan engklek, wawancara yaitu mewawancarai anak yang sedang melakukan permainan atau mewawancarai anak tentang permainan engklek sedangkan dokumentasi merupakan peneliti mendokumentasikan anak-anak yang sedang bermain permainan engklek dengan menggunakan instrumen ceklis. Teknis analisis data penelitian ini dengan menggunakan tiga kegiatan yaitu dengan reduksi, triangulasi data dan penarikan kesimpulan. Hasil dari penelitian ini merupakan untuk mengetahui manfaat yang terdapat pada permainan tradisional engklek dalam aspek perkembangan motorik kasar pada anak.
Electrical parameters of solar cells with electrodes made by selective metallization

Purpose – This paper aims to present the results of measurements of the photovoltaic structures made by electroless selective metallization technology. The developed technology provides low-cost contacts in any form, and parameters of photovoltaic cells made in this technology provide reliable results, comparable with those usually used. Design/methodology/approach – In this paper, photovoltaic cells with contacts based on Nip and NiCuP alloy were performed. As a substrate, mono- and multicristaline silicon was used. After photovoltaic cells have been prepared, sheet resistance of the contact layers and electrical parameters were measured. Composition and structure of contact layers were also measured. Findings – Obtained results of sheet resistance and contact layers are repeatable and comparable with previously published results. Electrical parameters of the photovoltaic cells made are comparable with used substrate and technologies. The authors have also noticed that the costs of the electroless metall.
Platelet-to-Lymphocyte Ratio Predicts the Presence of Diabetic Neurogenic Bladder

Purpose Diabetic neurogenic bladder (DNB) has been widely recognized in recent years. It is common in patients with long-term diabetes and may also lead to many severe complications. Although there has been widespread evidence that inflammation is involved in the development of some diabetic complications, there is little evidence that this can also occur in the bladder. In recent years, platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been viewed as potential novel markers of inflammatory responses. This study was designed to evaluate the relationship between the presence of DNB and the PLR and NLR. Patients and Methods A total of 371 cases of T2DM patients were included in this retrospective study. Patients were divided into two groups, with 115 diabetic subjects diagnosed with diabetic neurogenic bladder and 256 control subjects without DNB. The independent predictors of DNB were analyzed using logistic regression. Results Compared with patients without DNB, the mean PLR and NLR were significantly higher in those with DNB (p < 0.001). Based on the logistic regression, PLR was found to be an independent risk factor for DNB (odds ratio [OR]: 1.408, 95% confidence interval [CI]: 1.248–1.617). From the receiver operating characteristic (ROC) curve, using PLR as indicative of DNB was expected to be 101.1949, and it generated a sensitivity and specificity value of 89.6% and 23.4%, respectively. The area under the curve (AUC) was also found to be 0.899 (95% CI: 0.865–0.932). Conclusion In our study, PLR and NLR were significantly higher for patients with DNB. The PLR was found to be a risk factor in the presence of DNB after correcting for possible confounding factors. Considering the severe complications associated with DNB, patients with elevated PLR should be seriously cared for in clinics.
Evaluation of Microhardness of Two Bulk-fill Composite Resins Compared to a Conventional Composite Resin on surface and in Different Depths

Statement of the Problem: One of the problems with light-cured composite resins is the limitation and inadequate depth of curing and polymerization, resulting in low surface microhardness and restoration failure. Purpose: The present study aimed to compare the surface microhardness of two different bulk-fill composite resins and one conventional composite resin using the Vickers microhardness test. Materials and Method: In the present in vitro study, 108 samples from two different bulk-fill composite resins (Tetric N Ceram and Xtrafil) and one conventional composite resin (Filtek Z250) were prepared in metallic molds (2×4×10 mm) (n=36 for each composite resin). Six samples from each composite resin (n=6) underwent a hardness measurement test at specific depths (0.1, 1, 2, 3, 4 and 5mm). The samples were then stored at 37ºC for 24 hours, followed by a microhardness test at the depths mentioned above. Results: In all the composite resin samples, microhardness decreased with an increase in depth. The highest microhardness was recorded in Filtek Z250, followed by Xtrafil, with no significant difference. The lowest microhardness was recorded in Tetric N Ceram bulk-fill. Both bulk-fill composite resins at all the depths exhibited depth-to-surface standard microhardness (>80%). Conclusion: According to the results, both evaluated bulk-fill composite resins exhibited favorable surface microhardness up to a depth of 5 mm.
Gender Differences In Attitude To The Skin Disease- Atopic Dermatitis Among Adolescents: The Role Of Cognitive Behavioral Therapy

This paper examines gender differences in attitude to the skin disease-atopic dermatitis among adolescents: The role of CognitiveBehavioural Therapy. 83 adolescents aged between 13 and 15 and diagnosed with moderate (43) to grave (40) atopic dermatitis took part in the study. The groups were divided according to gender; group 1 was made up of 38 adolescent boys, and group 2 was made up of 45 adolescent girls. The control group included 80 adolescents (40 girls and 40 boys) matched for age. The psychodiagnostic complex used in the study were: Method for establishing the disease attitude type (DAT) and Male and Female Painting projective test. Data were analyzed using correlation and student’s t-test. The comparison of data yielded results that indicate gender-specific types of attitude to the disease among adolescents diagnosed with atopic dermatitis. A statistically significant difference between the groups was found in the anosognosic disease attitude type that is more typical of adolescent boys. This disease attitude type is characterized by active rejection of thoughts about the disease and its consequences which is explained by boy’s bravado, by their wish to demonstrate invulnerability and confidence, which is in effect an attempt to compensate for low selfappraisal.