Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Birmingham Young people and the management of chronic illness by primary care pharmacists

: Recent evidence has shown that the incidence of long-term illnesses in young people aged 10–24 years is increasing. It is essential to highlight the importance of long-term health conditions in this age group and understand young people’s health needs to be able to improve current support for young people. Pharmacists, as medicine experts, are in a unique position to promote young people’s health. The role of primary care pharmacists in the management of chronic illnesses in young people has not been widely researched. The aim of this review was to explore the current role of primary care pharmacists in the management of chronic illnesses in young people aged 10–24 years. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement using Medical Subject Headings (MeSH) and Embase subject headings (Emtree) terms, covering three main themes: Pharmacists, young people and chronic illnesses. Articles were critically appraised using Critical Appraisal Skills Programme (CASP) tools. Eight articles were included in this review. Seven articles included original research studies (one observational study, two surveys, two qualitative interview studies and two interventions). The remaining article was a literature review. All of the articles made reference to community pharmacists, while there was no information about GP pharmacists. Roles that community pharmacists identiﬁed as high-priority in their practice when dealing with young people included supporting young people to develop generic healthcare skills, counselling and building trusted relationships directly with young people, helping young people to ﬁnd credible health information and the provision of specialist services. Community pharmacists feel that they have a role to play in supporting young people with chronic illness and have identiﬁed many areas where they can provide services and support.
Gameful Self-Regulation: A Study on How Gamified Self-Tracking Features Evoke Gameful Experiences

Gamification has become one of the top engagement technology trends of recent times. It refers to designing and transforming systems, services, and activities to afford gameful experiences as good games do, commonly implemented through the utilization of familiar features from games. However, one of the persistent problems in academia and practice has been the lack of understanding of which systems features are more or less prone to facilitate which dimensions of the gameful experience. We investigate the relationships between user interaction with features related to goalsetting, self-tracking as well as prompts, and gameful experiences (accomplishment, challenge, competition, guidance, immersion, playfulness, and sociability) through a survey (N=201) in a gamified exercise service. Goal-setting and prompt features were positively associated with most dimensions of the gameful experience whereas self-tracking features were negatively associated with immersion and sociability while positively associated with feelings of
Cultural interventions and multi-disciplinary teams to enhance ‘ feeling at home ’ in ‘

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Spatial patterns of precipitation in Bosnia and Herzegovina

The paper investigates the spatial distribution of the seasonal and annual precipitation in Bosnia and Herzegovina. The mean monthly precipitation data from 40 meteorological stations covering the standard climatological thirty-year period (1961−1990) were used for the analysis. Seven precipitation-based parameters were used to regionalize climate in Bosnia and Herzegovina by using the Principal Component Analysis and clustering techniques. The spatial patterns of precipitation were determined by using the R-mode principal component analysis with varimax rotation. The first two principal components, which describe 97.60% of the total variance, were taken into consideration. The varimax rotated scores were subjected to the Cluster Analysis in order to identify homogeneous precipitation regions over the territory of Bosnia and Herzegovina. The agglomerative hierarchical clustering identified three sub-regions with different precipitation regimes. The complex orography, i.e., the influence of the Pannonian Basin, the Dinaric Alps, and the Adriatic Sea, is one of the most decisive factors that affect spatial patterns of precipitation in Bosnia and Herzegovina.
Primary Cardiac Lymphoma Manifesting as Complete Heart Block

Primary cardiac tumors are exceedingly rare with variable clinical manifestations. This case involves a patient presentation of symptomatic complete heart block and cardiac imaging revealing a right atrial mass invading the myocardium consistent with Burkitt lymphoma on histopathology. The patient received definitive bradytherapy with a pacemaker and chemotherapy for the primary cardiac lymphoma. After three cycles of chemotherapy, the right atrial mass regressed significantly with restoration of atrioventricular conduction and no pacing burden. Primary cardiac lymphomas infrequently manifest as atrioventricular block and this case highlights cardiac masses as a potential etiology when evaluating new conduction disturbances and bradyarrhythmias.
Does Islamic Banking Financing Help the Poor

This study aims to examine the effect of Islamic banking financing in helping poor people. Panel data starts from 2014q1-2018q2 collected from six countries were used in this study. The analysis method used is the panel data analysis. Private consumption expenditure is used to measure the level of poverty. Total Shariah- Compliant Financing is used to measure Islamic banking financing value. Several control variables are involved, such as conventional bank credit, consumer price index and economic growth. The result showed that Islamic banking financing has an effect in reducing the level of poverty better than conventional banking in these countries. Keyword: Islamic Banking, Poverty, Financing
A Bayesian Hierarchical Model for the Spatial Analysis of Carbon Monoxide Pollution Extremes in Mexico City

Air pollution by carbon monoxide is a serious problem that affects many cities around the world, and the theory of extreme values has played a crucial role in the study of this issue. In this paper, we proposed a Bayesian hierarchical spatial model of extreme values to evaluate the risk of extreme events of air pollution due to carbon monoxide in the metropolitan area of Mexico City. Spatial trends are modeled through of a Gaussian process for the generalized extreme value (GEV) distribution parameters, and prediction maps are produced for each of these. The results show a marginal spatial behavior for the location, scale, and shape parameters of GEV distribution, which indicate the existence of local variations that would not be possible to model using only stationary models. A return map of the maximum concentrations with a return period of one year is obtained. We found that the return levels for a one-year return period of CO concentration above 8 ppm in the Metropolitan Area of the Valley of Mexico are concentrated in the central part of this region, and the areas with the lowest estimates are distributed in the periphery. In addition, a quantile-quantile (QQ) plot between the theoretical and empirical quantiles was provided, which showed a very good fit of data to the proposed model.
Effect of Forage Feeding Level on Body Weight, Body Condition Score, Milk Production, and Milk Urea Nitrogen of Holstein Cows on an Organic Diet

In the past decade, a global demand for products from organic agriculture has increased rapidly. Milk quality is of major interest to all parties. Therefore, the objective of this study was to compare cow performance and product quality on conventional and organic diets. 72 Holstein dairy cows were allotted to one of four diets: a conventional diet (CON40), an organic diet with a low amount of forage (ORG40), an organic diet with a moderate amount of forage (ORG60) and an organic diet with a high amount of forage (ORG80). Multiparous cows (2nd, 3rd, and 4th parity) were randomly assigned to the treatments. Range forages were used as part of the diets, and cows were individually offered feed three times a day with refusals collected once a day. Daily dry matter intake (DMI) and milk yield (MY) were measured for 308 days. Somatic cell count (SCC), body weight (BW) and feed efficiency (FE) were determined at 28-day intervals. The DMI was different for cows that consumed the ORG80 (18.2 kg/d), ORG60 (19.1 kg/d), ORG40 (20.1 kg/d) and CON40 (20.5 kg/d) diets. BW was not affected by treatments, but differences in body condition score (BCS) (P<0.05) were observed. Although milk yield was higher in cows fed CON40, milk fat was higher (P<0.05) in cows fed organic diets. Lower FE, milk urea nitrogen (MUN) and blood urea nitrogen (BUN) were observed in cows fed organic diets (P<0.05).
Aerosol retrievals from different polarimeters during the ACEPOL campaign using a common retrieval algorithm

Abstract. In this paper, we present aerosol retrieval results from the ACEPOL (Aerosol Characterization from Polarimeter and Lidar) campaign, which was a joint initiative between NASA and SRON – the Netherlands Institute for Space Research. The campaign took place in October–November 2017 over the western part of the United States. During ACEPOL six different instruments were deployed on the NASA ER-2 high-altitude aircraft, including four multi-angle polarimeters (MAPs): SPEX airborne, the Airborne Hyper Angular Rainbow Polarimeter (AirHARP), the Airborne Multi-angle SpectroPolarimetric Imager (AirMSPI), and the Research Scanning Polarimeter (RSP). Also, two lidars participated: the High Spectral Resolution Lidar-2 (HSRL-2) and the Cloud Physics Lidar (CPL). Flights were conducted mainly for scenes with low aerosol load over land, but some cases with higher AOD were also observed. We perform aerosol retrievals from SPEX airborne, RSP (410–865 nm range only), and AirMSPI using the SRON aerosol retrieval algorithm and compare the results against AERONET (AErosol RObotic NETwork) and HSRL-2 measurements (for SPEX airborne and RSP). All three MAPs compare well against AERONET for the aerosol optical depth (AOD), with a mean absolute error (MAE) between 0.014 and 0.024 at 440 nm. For the fine-mode effective radius the MAE ranges between 0.021 and 0.028 µm . For the comparison with HSRL-2 we focus on a day with low AOD (0.02–0.14 at 532 nm) over the California Central Valley, Arizona, and Nevada (26 October) as well as a flight with high AOD (including measurements with AOD>1.0 at 532 nm) over a prescribed forest fire in Arizona (9 November). For the day with low AOD the MAEs in AOD (at 532 nm) with HSRL-2 are 0.014 and 0.022 for SPEX and RSP, respectively, showing the capability of MAPs to provide accurate AOD retrievals for the challenging case of low AOD over land. For the retrievals over the smoke plume a reasonable agreement in AOD between the MAPs and HSRL-2 was also found (MAE 0.088 and 0.079 for SPEX and RSP, respectively), despite the fact that the comparison is hampered by large spatial variability in AOD throughout the smoke plume. A good comparison is also found between the MAPs and HSRL-2 for the aerosol depolarization ratio (a measure of particle sphericity), with an MAE of 0.023 and 0.016 for SPEX and RSP, respectively. Finally, SPEX and RSP agree very well for the retrieved microphysical and optical properties of the smoke plume.
In Vivo Metabolic and Vascular Response to Hypoxia in Twist Knockdown Murine Breast Cancer

Twist transcription factor is often overexpressed in aggressive tumors. Although needed in early embryonic development for organogenesis, Twist is known to induce an epithelial to mesenchymal transition in cells. In cancer, epithelial to mesenchymal transitions can lead to increased motility and invasiveness. It has also been linked to metabolic reprogramming and increased metastatic risk. Furthermore, metabolic preferences can increase proliferation, enhance metastatic potential, and influence the site of metastasis. We hypothesize that Twist directly affects the metabolism of cancer cells. We expect to see in vivo what we have seen in vitro; Twist overexpression should promote a shift away from glycolysis in response to reperfusion. To study the effects of Twist on metabolism in vivo tumors were grown in the dorsal skinfold window chamber and stressed by exposure to hypoxia. Knowledge of metabolism without information on the oxygen availability is incomplete because cell metabolism naturally shifts between oxidative phosphorylation and glycolysis in response to variations in oxygen availability. Knowing if oxygen is readily available is particularly important when studying cancer metabolism because tumors may have poor vasculature organization due to angiogenesis not keeping up with tumor growth. To know if metabolic changes are due to intrinsic or extrinsic factors hyperspectral imaging was used to determine vascular oxygenation within the tumor. Multiphoton microscopy was used to quantify metabolism on the cellular level by measuring the optical redox ratio as well as the relative contribution ratio of free and bound NADH. We found the optical redox ratio, vascular oxygenation, and hemoglobin concentration were affected more by hypoxia in the cell line not expressing Twist. This would suggest that Twist does have a direct impact on metabolism within the cell. Because multiphoton imaging was not performed during hypoxia, whether Twist causes quicker metabolic changes or causes resistance to metabolic change remains to be determined. Table of
Floristic diversity and demographic structure of the Sidi R'Ghies forest, north-eastern of Algeria

Abstract. Rached-Kanouni M, Kara K, Khammar H, Ababsa L. 2020. Floristic diversity and demographic structure of the Sidi R'Ghies forest, north-eastern of Algeria. Biodiversitas 21: 875-881. In Algeria, the degradation of the ecosystems induces a loss of biodiversity and an increase in the adverse effects of climate change and anthropogenic actions, especially at the level of the ecosystems of semi-arid zones. This study aims to determine the floristic composition and demographic structures of different stands within the Sidi R'Ghies forest, north-east of Algeria. Data were collected using floristic surveys, diameter measurements at 1.30 m and total height for trees in four plots with size for each plot of 1000 m2. The diversity indices have been calculated on the basis of specific frequencies. The analysis revealed a low floristic richness with 6 woody species belonging to 5 families with the most dominant are the Cupressaceae and Fagaceae (29%). The low density of woody trees (97.78 individuals/ha) was found in Plot 1 and the high density of 205.56 individuals/ha was found in Plot 4. The diametric structure adjusts to the Weibull distribution and shows a predominance of young individuals. The distribution of trees in height classes shows a single distribution with an asymmetric curve. This positive distribution reveals a predominance of individuals with a height between 2 and 8 m (sapling to mature stage). This work, which provides an overview of the state of the floristic diversity of the Sidi R’Ghies forest, allows taking appropriate measures to safeguard our plant resources.
Experience of Laparoscopic Urology Surgery at a Territory Hospital, Addis Ababa, Ethiopia

ABSTRACTIntroduction: For several decades minimal access surgery has become the path of preference in the treatment of most surgical diseases of the urinary tract; replacing open surgery. It is a common treatment modality in the developed countries unlike the developing countries. In Ethiopia, retroperitoneoscopic renal cysts decortications was introduced for the first time, by our team.Objective: To determine the outcome of minimal access urologic surgeries at SPHMMCMethods: A prospective study was conducted on patients for whom laparoscopic urology surgeries were performed from January 1, 2017 to June 31, 2017 in St Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.Results: 33 laparascopic urology surgeries were performed in the study period. 20 were renal cysts excision, 11 Nephrectomies and the remaining 2 were Ureterolithotomies. For all procedures there was no significant blood loss (<70ml). After laparoscopic cystectomy the post-operative hospital stay was 24 hours and all patients started routine work on average of 15 days. After laparoscopic ureterolithotomy the total hospital stay was 48 hours. At the 15th post OP day both patients started their routine work. After laparoscopic nephrectomy all patients were discharged after 48-hours, and on average at the 21st day they started their routine work.Conclusion: Minimally invasive surgery is a safe and effective option, for the treatment of renal cyst, ureterolithiasis and pathologies requiring nephrectomy. It provides a shorter hospital stay, earlier return to work than open surgery. Keywords: Retroperitoneoscopy; Renal cyst decortications; Ureterolithotomy; Retroperitoneoscopic Nephrectomy, Hand-assisted transperitoneal laparoscopic nephrectomy
Resilience trinity: safeguarding ecosystem functioning and services across three different time horizons and decision contexts

Ensuring ecosystem resilience is an intuitive approach to safeguard the functioning of ecosystems and hence the future provisioning of ecosystem services (ES). However, resilience is a multi‐faceted concept that is difficult to operationalize. Focusing on resilience mechanisms, such as diversity, network architectures or adaptive capacity, has recently been suggested as means to operationalize resilience. Still, the focus on mechanisms is not specific enough. We suggest a conceptual framework, resilience trinity, to facilitate management based on resilience mechanisms in three distinctive decision contexts and time‐horizons: 1) reactive, when there is an imminent threat to ES resilience and a high pressure to act, 2) adjustive, when the threat is known in general but there is still time to adapt management and 3) provident, when time horizons are very long and the nature of the threats is uncertain, leading to a low willingness to act. Resilience has different interpretations and implications at these different time horizons, which also prevail in different disciplines. Social ecology, ecology and engineering are often implicitly focussing on provident, adjustive or reactive resilience, respectively, but these different notions of resilience and their corresponding social, ecological and economic tradeoffs need to be reconciled. Otherwise, we keep risking unintended consequences of reactive actions, or shying away from provident action because of uncertainties that cannot be reduced. The suggested trinity of time horizons and their decision contexts could help ensuring that longer‐term management actions are not missed while urgent threats to ES are given priority.
ORGAN POLSKIEGO TOWARZYSTWA GINEKOLOGÓW I POŁOŻNIKÓW THE OFFICIAL JOURNAL OF THE POLISH SOCIETY OF GYNECOLOGISTS AND OBSTETRICIANS

objectives: To establish the appropriate technique for salpingo-oophorectomy via transvaginal natural orifice transluminal endoscopic surgery (NOTES), under gasless laparoscopy. Material and methods: Ten patients with clinical indication underwent gasless laparoscopic transvaginal salpingo-oophorectomy with concurrent vaginal hysterectomy. An abdominal-wall lifting device was used after removal of the uterus, and the adnexa was removed trans-vaginally by gasless laparoscopy. The perioperative clinical data, such as operative duration, volume of blood loss, morbidity, intraoperative and postoperative complications, and length of hospital stay, were retrospectively analyzed. results: All procedures were successfully done, without any intraoperative or major postoperative complications, and no additional transabdominal ports were required. The salpingo-oophorectomy part of the procedure was completed in approximately 11–40 minutes, with minimal blood loss. All of the patients were discharged, scar-free, 2–4 days after surgery. Conclusions: Transvaginal NOTES with gasless laparoscopy is a feasible and safe surgical technique in cases involving difficult vaginal salpingo-oophorectomy, which avoids conversion to an abdominal route.
Association of biofilm formation with multi drug resistance in clinical isolates of Pseudomonas aeruginosa

Pseudomonas aeruginosa is considered as foremost cause of hospital acquired infections due to its innate and plasmid mediated resistance to multiple antibiotics making it a multi drug resistant (MDR) pathogen. Biofilm formation is a pathogenic mechanism harbored by this pathogen which further elevates its resistance to antibiotics and host defense system. The aim of the present study was to evaluate the biofilm forming potential and distribution of pslA gene in multi drug resistant Pseudomonas aeruginosa isolates obtained from different clinical samples. A total of 200 different clinical samples were collected after obtaining written consent from the patients. The samples were subjected to isolation and identification of P. aeruginosa by standard microbiological procedures. Confirmation of isolates was done by polymerase chain reaction targeting oprL gene. Kirby Bauer method was performed for detection of MDR isolates. Congo red agar (CRA) test and Microtiter plate assay (MPA) for observing the biofilm forming ability and amplification of pslA gene was also performed on MDR isolates. The results showed that from 200 samples 52 (26 %) were P. aeruginosa and among them 20 (38.46 %) were MDR isolates. The CRA showed 23 (44.23 %) while MPA detected 49 (94.23 %) isolates as biofilm producers while all the MDR isolates showed biofilm formation by MPA method. The pslA gene was detected in all biofilm forming isolates while 90 % in MDR P. aeruginosa. It was concluded that biofilm forming P. aeruginosa are more resistant to tested antibiotics and biofilm formation is strongly associated with presence of pslA gene.