Miracle-dz/UniFAR-FTUs huggingface dataset:
LIVER-RELATED AND OTHER-CAUSE MORTALITY RISK IN EXCESSIVE DRINKERS: ANALYSIS OF DATA FROM THE UK BIOBANK

Background and Aims High alcohol intake is associated with increased mortality. We aimed to identify factors affecting mortality in people drinking extreme amounts. Approach and Results. Information was obtained from the UK Biobank on approximately 500,000 participants aged 40-70 years at baseline assessment in 2006-2010. Habitual alcohol intake, lifestyle and physiological data, laboratory test results, and hospital diagnoses and death certificate data (to June 2020) for 5136 men (2.20% of male participants) and 1504 women (0.60%) who reported taking [≥]80 g/day or [≥]50g/day, respectively, were used in survival analysis. Compared to all other participants, their mortality HRs were 9.40 (95% CI 7.00-12.64) for any liver disease (ICD-10 K70-K76), 2.02 (1.89-2.17) for all causes, 1.89 (1.69-2.12) for any cancer (C00-C99), and 1.87 (1.61-2.17) for any circulatory disease (I00-I99). Liver disease diagnosis or abnormal liver function tests predicted not only deaths attributed to liver disease but also those from cancers or circulatory diseases. Mortality among excessive drinkers was also associated with quantitative alcohol intake, diagnosed alcohol dependence (ICD-10 F10.2), and current smoking at assessment. Conclusions. People with chronic excessive alcohol intake experience decreased average survival but there is substantial variation in their mortality, with liver abnormality and alcohol dependence each associated with worse prognosis. Clinically, patients with these risk factors as well as high alcohol intake should be considered for early or intensive management. Research can usefully focus on the factors predisposing to dependence or liver abnormality.
The Inheritance of Carcass and Meat Quality

In Japanese quail (coturnix coturnix japonica), heritabilities of quality-related carcass and meat traits are moderate to high. It was shown by various researchers that selection for increased and/or decreased quail body weight had some correlated effects on quality-related carcass and meat traits. Now, Japanese quail farming for meat production expanded in several countries. Future strategy for meat quail selection and breeding in research studies or in practice should take into account knowledge on the heredity of those traits.
Examining the determinants of union dissolution among married and common-law unions in Canada

This paper examines the determinants of union dissolution among first marriage, second marriage, and common-law unions via an event history analysis of the fourth panel of the Survey of Labour and Income Dynamics (SLID). Results suggest that unemployment and other potentially challenging employment situations are associated with higher odds of dissolution, among first marriage unions in particular. The factors that predict union dissolution are found to differ, both across union types and within common-law unions by region (Quebec versus elsewhere in Canada).
A thymus-specific member of the HMG protein family regulates the human T cell receptor enhancer

The human T cell-specific transcription factor TCF-la plays a key role in the tissue-specific activation of the T cell receptor (TCR) Ca enhancer and binds to pyrimidine-rich elements (5'-PyCTTTG-3') present in a variety of other T cell-specific control regions. Using amino acid sequence information derived from the DNA affinity-purified protein, we have now isolated cDNA clones encoding TCF-la. The TCF-Ia cDNA contains a single 68-amino-acid domain that is homologous to a region conserved among high-mobility group (HMG) and nonhistone chromosomal proteins. Expression of full-length and mutant cDNA clones in bacteria reveal that the single HMG motif, which is predicted to contain two extended a-helical segments, is sufficient to direct the sequence-specific binding of TCF-lc~ to DNA. Northern blot experiments demonstrate further that TCF-I,~ mRNA is highly tissue specific, found primarily in the thymus or T cell lines. The immature CEM T cell line expresses relatively low levels of TCF-la mRNA, which are increased upon activation of these cells by phorbol esters. Interestingly, the cloned TCF-I¢~ protein is a potent transcriptional activator of the human TCRa enhancer in nonlymphoid cell lines, whereas the activity of the endogenous protein in T cell lines is strongly dependent on an additional T cell-specific protein that interacts with the core enhancer. TCF-let is currently unique among the newly emerging family of DNA-binding regulatory proteins that share the HMG motif in that it is a highly tissue-specific RNA polymerase II transcription factor.
Three-dimensional discrete element modeling of direct shear test for granular 1 rubber sand 2

Can Wang, An Deng, Abbas Taheri Three-dimensional discrete element modeling of direct shear test for granular rubber-sand Computers and Geotechnics, 2018; 97:204-216 © 2018 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ Final publication at http://dx.doi. org/10.1016/j.compgeo. 2018.01. 014
INFLUENCE OF NON-PLASTIC FINES ON THE RESPONSE OF A SILTY SAND TO CYCLIC LOADING

Data from cyclic loading tests on sand-ˆne mixtures made of Ahmedabad sand and quarry dust are presented. Tests were performed at constant void ratio, constant relative density and constant sand skeleton void ratio, for a variety of ˆnes contents. Instead of looking at the direct eŠect of ˆnes content on the cyclic response of the sand-ˆne mixtures, a novel approach of analysing the cyclic test data is proposed, by normalising these data with respect to state. The important diŠerence with other similar work on plain sand is that the reference line for normalising must take account of the ˆnes content. Simple deˆnitions of equivalent void ratio, which take account of ˆnes content, have been used. The results presented indicate that state plays an important role in deˆning the cyclic resistance ratio and pore water pressure generation during cyclic loading.
Provocation of electric hypersensitivity under everyday conditions

Provocation of electric hypersensitivity under everyday conditions. Scand J Objectives In most previous provocation studies subjects suffering from "electric hypersensitivity" have not been able to determine correctly whether or not they have been subjected to a sham or true provocation to magnetic or electric fields. However, an often-discussed weakness is that most of the earlier provocation studies have been performed in a laboratory situation, often with simulated fields, which may not be representative of conditions prevailing in the homes or workplaces of the patients. Criticism has also been put forth about neglect of the long latency period of symptoms. Therefore, a provocation study was performed in the homes or workplaces of the patients, where we also studied the symptoms and on-off answer 24 hours after the exposure. Methods Fifteen subjects selected as having fast and distinct reactions from electric equipment were provoked on 4 occasions: mainly 2 true and 2 sham provocations. The intervals between exposure were a few or more days in order to provide the subjects with an opportunity to recover before the next provocation. A control group of healthy subjects with normal hearing and vision verified that the provocations were performed in a blind manner. Results The patients suffering from "electric hypersensitivity" were no better than the control group in deciding whether or not they were exposed to electric and magnetic fields. C O ~ ~ C ~ U S ~ O ~ S Exposure to electlic and magnetic fields per se does not seem to be a sufficient cause of the symptoms experienced by this patient group.
Health and Disability The role of dark-side of motivation and intention to continue in exercise: A self-determination theory approach

Department of Sport Sciences, University of Beira Interior, Portugal Research Centre in Sports, Health and Human Development, CIDESD, Portugal Faculty of Physical Education and Sport, ULHT, Lisbon, Portugal Sport Science School of Rio Maior, Polytechnique Institute of Santarem, Rio Maior, Portugal Laboratory of Physical Activity Neuroscience (LABNAF), Physical Activity Sciences Post-Graduate Program, Salgado de Oliveira University, Brazil Laboratory of Panic and Respiration (LABPR), Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil Intercontinental Neuroscience Research Group, Brazil
IN VIVO EVALUATION OF ELECTROSPUN POLY (VINYL ALCOHOL)/SODIUM ALGINATE NANOFIBROUS MAT AS WOUND DRESSING

In this study, potential of the alginate based electrospun nanofibrous mats as wound dressings was investigated macroscopically in vivo experiments. 2/1 (v/v) %9 PVA / %1 NaAlg nanofibrous mats were produced by electrospinning method. In order to improve water resistance of the electrospun mats, the cross-linking was performed. SEM analyses, thickness and air permeability tests were applied for the nanofibrous mats produced as wound dressing and Suprasorb-A commercial alginate wound dressing. In vivo experiments, the healing performances of the wounds dressed by using cotton gauze, Bactigras, Suprasorb-A and the electrospun PVA/NaAlg nanofibrous mat were macroscopically evaluated and compared. The wound healing potential of the electrospun mat was better than that of cotton gauze including a drug and looked like antibacterial Bactigras. The results indicated that the electrospun PVA/NaAlg nanofibrous mat as wound dressing provided a good means for wound healing.
Children’s understanding of time: A study in a primary history classroom1

This paper reports findings from a study of Portuguese primary children’s understanding of time and historical time. The research involved two classes (first grade, with 24 students aged 6 to 7, and third grade, with 25 students aged 8 to 9) of primary school students during two school academic years in an urban primary school in northern Portugal. The main aim of the study was to analyse how students from the first to fourth grade of education develop chronological (time) concepts and historical understanding. Different data collection techniques and methodologies were used that allowed for three types of triangulation. Data were collected through semi-structured interviews, open interviews, participant researcher observation, audio data, field notes and class diaries. The research was undertaken by the researcher and the class teacher. The research was carried out though a longitudinal study over two years. At three times during the study, the students were asked to arrange historical pictures in chronological order and to explain their sequences. The research data were analysed using a deductive approach. This allowed the construction of a conceptualization system with parameters, categories and subcategories. The findings suggest that temporal understanding and historical thinking are developed gradually but, significantly, they can be facilitated and accelerated by means of specific social studies/history teaching strategies and pedagogy – that is, an intervention strategy.
Analysis of the blast wave decay coefficient using the Kingery–Bulmash data

A growing interest for the design of structures to sustain blast-induced loads has been observed in recent years as a result of the worldwide rise of terrorist bombing attacks. The blast loading is usually characterized by a sudden increase in the pressure followed by an exponential decay. The parameters of this pressure pulse are essential for design and can be found in various blast design manuals available in the open literature. One of the most widely used sources is a technical report by Kingery–Bulmash, which provides values for many blast parameters in diagrams and polynomial form. However, it does not include an equation for calculating the blast wave decay coefficient, necessary for constructing the pressure–time history of an explosion at a certain point. In this study, a review of the technical literature that contains expressions for the blast pressure decay coefficient is performed, and relevant comparisons have been made. New equations describing the decay coefficient of the Friedlander equation for both incident and reflected cases for free-air and surface bursts are proposed. These equations express the decay coefficient in terms of the scaled distance and are not valid for close-in detonations. They are entirely based on the Kingery–Bulmash data, and their accuracy is satisfactorily checked against new experimental results and their trends assessed through a sensitivity analysis. Accordingly, the positive phase of the pressure–time curve at a point can be reliably and efficiently generated.
Entrepreneurship emerges under the conditions of uncertainty , to which trust is a response

1 1. Entrepreneurship emerges under the conditions of uncertainty, to which trust is a response3 2. The notion of trust and the link with values . 5 3. Particular trust . 12 3.1 Family as a carrier of trust. 16 3.2 Effectuation and trust-building as part of the entrepreneurial process. 21 4. Extended trust . 26 5. Macro-micro and micro-macro linkages . 34 6. The role of new technology in enhancing (or replacing) trust . 40 7. Conclusions . 49 8. References . 54
VITAMIN CONTENT OF MARINE RED ALGA CHAMPIA PARVULA

Objective: The current investigation focuses on determining the vitamin content of marine red alga Champia parvula . Methods: Vitamins were divided and analyzed using Milichrom A-02 LC and multiwavelength ultraviolet visible as a detector. A 2 mm (ID)×250 mm (l) column was used to filter comprising C18 in the inverse stage used for separation. Results: The results suggest that the seaweed, C. parvula, contains 0.583±0.01, 3.43±0.01, 4.95±0.01, 1.95±0.01, 6.33±0.00, 174.74±0.01, and 15.75±0.01 µg of Vitamin A, B1, B5, folic acid, B12, C, and E, respectively, per gram of dry weight of the seaweed. Conclusion: The findings indicate that the seaweed, C. parvula , has a higher nutritional value and could be used as great dietary supplements for vitamins.
FACTORS AFFECTING TIMELY COMPLETION OF CONSTRUCTION PROJECTS

ABSTRACT It is common to experience delays during construction projects. Delays do not always result from a single catastrophic event. Delays can cause substantial damages to an owner. This has motivated the owners to devise contract provisions and project processes to anticipate, manage and compensate for such delays. Many studies have been carried out to assess the causes of delays in construction projects. They are found to be almost similar, except some prevailed local condition. Most of the common construction delay factors are attributed to design faults, incompetent contractor, lack of team accountability etc. The root causes of delays found out in this paper are not so much different than previous studies. To minimize or eliminate the delay we have to follow the recognized fundamental principles of management such as: cost-time relationship, time priority, accountability, rewards, knowledge, efficiency, innovative thinking etc. If the implementing agencies properly followed the above stated management principles and some other related corrections as recommended in the paper, much construction delays can be avoided.
Is Cognitive Linguistics deadly sinful? On the pros and cons of Cognitive Linguistics and its development

Cognitive Linguistics started from the 1980s, and it has become a mainstream since the end of the last century and the beginning of this century, which has got widespread attention, with a nickname as the third revolution in linguistic circles after the Saussurean Revolution and the Chomskyean Revolution. According to the dialectical principle of “negation of negation”, theoretical research is always advancing, thus the linguists are beginning to think of the shortcomings of Cognitive Linguistics and new developments in the future. For instance, Dabrowska (2016) pointed out the seven deadly sins of Cognitive Linguistics, which, we think, are overstated and too radical. Cognitive Linguistics has its own historical significance and makes great contributions to the criticism of Saussurean “Linguistic Apriorism” and Chomskyean “Linguistic Nativism”, but Cognitive Linguistics also has its own weaknesses, which are to be exposed in brief in this paper. We have also tried to propose “Embodied-Cognitive Linguistics as a revision in order to emphasize the philosophical views of “materialism” and “humanism” as a basic start in linguistic research.
Ordinal regression models for predicting deoxynivalenol in winter wheat

Deoxynivalenol (DON) is one of the most prevalent toxins in Fusarium -infected wheat samples. Accurate forecasting systems that predict the presence of DON are useful to underpin decision making on the application of fungicides, to identify ﬁelds under risk, and to help minimize the risk of food and feed contamination with DON. To this end, exist-ing forecasting systems often adopt statistical regression models, in which attempts are made to predict DON values as a continuous variable. In contrast, this paper advocates the use of ordinal regression models for the prediction of DON values, by deﬁning thresholds for converting continuous DON values into a ﬁxed number of well-chosen risk classes. Objective criteria for selecting these thresholds in a meaningful way are proposed. The resulting approach was evaluated on a sizeable ﬁeld experiment in Belgium, for which measurements of DON values and various types of predictor variables were collected at 18 locations during 2002 – 2011. The results demonstrate that modelling and evaluating DON values on an ordinal scale leads to a more accurate and more easily interpreted predictive performance. Compared to traditional regression models, an improvement could be observed for support vector ordinal regression models and proportional odds models.
Applications of Fourier Transform Infrared Spectrometry to Studies of Copper Corrosion under Bacterial Biofilms

Copper pipework has been reported to undergo pitting corrosion. The corrosion reactions appear to involve the activities of microorganisms embedded in the overlying biofilm. Attenuated total reflection Fourier transform infrared spectroscopy provided a useful approach to evaluate the types of microbial metabolites that accumulate at the metal surface. Specific strains of bacteria cause deterioration of copper metal surfaces during growth and biofilm development under static and flowing bulk phase conditions. Acidic polysaccharide components of the exopolymers excreted by the surface-associated bacteria promote oxidation of the copper surface
Quality of life after early enteral feeding versus standard care for proven or suspected advanced 1 epithelial ovarian cancer: results from a randomised trial 2

27 Background: Malnutrition is common in patients with advanced Epithelial Ovarian Cancer (EOC), and 28 is associated with impaired quality of life (QoL), longer hospital stay and higher risk of treatment ‐ 29 related adverse events. This phase III multi ‐ centre randomised clinical trial tested early enteral 30 feeding versus standard care on postoperative QoL. 31 Methods: From 2009 ‐ 2013, 109 patients requiring surgery for suspected advanced EOC, moderately 32 to severely malnourished were enrolled at five sites across Queensland and randomised to 33 intervention (n=53) or control (n=56) groups. Intervention involved intraoperative nasojejunal tube 34 placement and enteral feeding until adequate oral intake could be maintained. Despite being 35 randomised to intervention, 20 patients did not receive feeds (13 did not receive the feeding tube; 7 36 had it removed early). Control involved postoperative diet as tolerated. QoL was measured at 37 baseline, 6 weeks postoperatively and 30 days after the third cycle of chemotherapy. The primary 38 outcome measure was difference in QoL between intervention and control group. Secondary 39 endpoints included treatment ‐ related adverse event occurrence, length of stay, postoperative 40 services use, and nutritional status. 41 Results: Baseline characteristics were comparable between treatment groups. No significant 42 difference in QoL was found between the groups at any timepoint. There was a trend towards better 43 nutritional status in patients who received the intervention but the differences did not reach statistical 44 significance except for the intention-to-treat analysis at 7 days postoperatively (11.8 intervention vs. 45 13.8 control, p 0.04). 46 Conclusion: Early enteral feeding did not significantly improve patients’ QoL compared to standard 47 of care but may improve nutritional status.
Regulation of D-0-Hydroxybutyrate Dehydrogenase in Rat Hepatoma Cell Lines

Quantitation of i>-/3~liy<lro\>butvratc dehydrogenase (BDH) in normal rat hepatocytes was compared with that in two rat hepatoma cell lines, H4-II-EC3 and RLT-3C. BDH activity in normal rat hepatocyte mito chondria was 321 nmol/min/mg, which was greatly reduced to 10.7 nmol/ min/mg and 1.7 nmol/min/mg in H4-II-EC3 and RLT-3C cell mitochon dria, respectively. The cell growth rate and L-[35Slmethionineincorpora tion rate showed that RLT-3C cells had the highest growth rate (32.4-h doubling time) and the fastest protein biosynthesis rate (2.65 x 10scpm/ min/106 cells). The H4-II-EC3 cell line grew more slowly (48.5-h dou bling time) and had lower protein biosynthesis rate (1.46 x IO5cpm/min/ Id'1cells). The protein synthesis rate in hepatocytes was 1.25 x 10scpm/ min/106 cells. These results suggest that there is a reciprocal correlation between BDH activity and cell growth and protein synthesis rates. Immunochemical quantitation of BDH showed the amount of BDH in H4-II-EC3 and RLT-3C cells was about 4.8 and 0.5% of that in normal rat hepatocytes, respectively. Quantitation of BDH by biosynthesis in dicated that BDH content in H4-II-EC3 cells and RLT-3C cells was 9.3 and 4.0% of that of normal hepatocytes, respectively. Precursor BDH synthesized by in vitro translation primed with RNA of H4-II-EC3 cells or RLT-3C cells was 3.0 and 1.1% of that translated from normal rat hepatocyte RNA. These results suggest that the decrease in BDH content in hepatoma cells results from a decrease in functional BDH-mRNA. The coupling of a decrease in BDH activity with an increase in activity of succinyl-CoA: acetoacetyl-CoA transferase in hepatoma cells may play a role in generating additional energy required for the rapid growth of tumor cells.
E Evolution of the Brain , The

The field of evolutionary neuroscience has provided us with an enormous amount of comparative data and relevant theoretical principles to support our current understanding of the evolution of the nervous system. Evolutionary neuroscientists are interested in understanding how the brain evolves and in reconstructing the natural history of the nervous system from a structural and functional perspective. Evidence of brain evolution can be documented through the lens of various biological fields, including biological anthropology, ethology, paleontology, comparative psychology, comparative neuroanatomy, cognitive science, and molecular biology and genetics. The brain, like other organs of the body, is a result of evolutionary processes which have shaped its structure and function. Some of these evolutionary forces have uniquely adapted each nervous system to the environment in which that species lives, while others (either due to shared environmental pressures or common developmental/phylogenetic/architectural plans) have generated remarkable similarities across species.