Miracle-dz/UniFAR-FTUs huggingface dataset:
Lessons Learned From an Effectiveness Evaluation of Inlife, a Web-Based Social Support Intervention for Caregivers of People With Dementia: Randomized Controlled Trial

Background Informal care for people with dementia not only affects the well-being of the primary caregiver but also changes their roles and interactions with the social environment. New online interventions might facilitate access to social support. Recently, an online social support platform, Inlife, was developed in the Netherlands and aims to enhance social support and positive interactions in informal support networks. Objective This study aimed to evaluate the effectiveness of Inlife for caregivers of people with dementia. Methods A randomized controlled trial with 96 caregivers of people with dementia was performed. Participants were randomly assigned to the Inlife intervention or the waiting list control group. After 16 weeks of Inlife use, the waiting list control group could start using Inlife. Effects were evaluated at baseline (T0), 8 weeks (T1), and 16 weeks (T2). The 16-week follow-up assessment (T2) served as the primary endpoint to evaluate the results for the primary and secondary outcome variables evaluated with online self-report questionnaires. The primary outcomes included feelings of caregiver competence and perceived social support. The secondary outcomes included received support, feelings of loneliness, psychological complaints (eg, anxiety, stress), and quality of life. Results No significant improvements were demonstrated for the intervention group (n=48) relative to the control group (n=48) for the primary outcomes (feeling of carer competence: b=–0.057, 95% CI –0.715 to 0.602, P=.87; perceived social support: b=–15.877, 95% CI –78.284 to 46.530, P=.62) or any secondary outcome. This contrasts with our qualitative findings showing the potential of Inlife to facilitate the care process in daily life. Adherence was not optimal for all Inlife users. Additional per-protocol and sensitivity analyses also revealed no beneficial results for high active Inlife users or specific subgroups. Inlife users were more active when part of a larger network. Conclusions Researchers should be modest regarding the effectiveness of online caregiver interventions in terms of quantitative measures of well-being and quality of life. Nevertheless, online tools have the potential to facilitate the caregiver process in daily life. Lessons learned include the importance of harnessing the power of human interaction in eHealth, making use of the user’s social capital, and the need to develop research methods that can identify benefits in daily life that are ecologically valid for caregivers. Trial Registration Netherlands Trial Register NTR6131; https://trialsearch.who. int/Trial2.aspx? TrialID=NTR6131 International Registered Report Identifier (IRRID) RR2-10.1186/s13063-017-2097-y
Inspired by the Nature: A Post-printed Strategy to Efficiently Elaborate Parahydrophobic Surfaces

The lack of drinkable water is one of the most significant risks for the future of the humanity. Estimates show that in the near future, this risk will become the origin of massive migrations leading to humanitarian disaster. As consequence, the development of solutions to provide water is becoming ever more critical, and a significant effort is devoted to identifying new sources of water. Among the developed strategies, fog harvesting, which takes advantage of atmospheric water to provide potable water, is a solution of interest due to its potential in sustainable development. Unfortunately, this approach suffers from low yield. In the present work, we take inspiration from living species to design and elaborate surfaces with high potential for water harvesting applications. This work takes advantage of 3D-printing and post-printing functionalization to elaborate a strategy that allows modelling, printing, and functionalization of surfaces to yield parahydrophobic behavior. The roughness and surface morphology of the prepared surfaces were investigated. These characteristics were then related to the observed wettability and potential of the functionalized interfaces for water harvesting applications. This work highlights significant variations in surface wettability via surface modification; strong hydrophobic behavior was observed via modification with linear carboxylic acids particularly for surfaces bearing vertical blades (plate with vertical blades and grid with vertical blades).
The Effect of Home and In-Office Bleaching on Microhardness and Color of Different CAD/CAM Ceramic Materials

The aim of this study is to assess the effect of different bleaching agents on microhardness and color of CAD/CAM ceramics including IPS e.max CAD (lithium disilicate), VITA ENAMIC (polymer-infiltrated ceramic), and Celtra Duo CAD (zirconia-reinforced lithium silicate). Materials’ samples were divided into three groups (n = 10) and each received a different bleaching treatment; 20% carbamide peroxide, 35% carbamide peroxide, and 40% hydrogen peroxide. A fourth group was stored in water acting as a control. Vickers microhardness and spectrophotometric color measurements were taken at baseline and after bleaching. IPS e.max CAD showed a significant reduction (about 14%), while VITA ENAMIC showed a significant increase (about 78%) in microhardness after bleaching (p ˂ 0.001). Celtra Duo CAD did not demonstrate a significant change in microhardness (p ≥ 0.609). The color difference (ΔEab) after bleaching was 0.29 (±0.08), 2.84 (±0.64), and 1.99 (±0.37) for IPS e.max CAD, VITA ENAMIC, and Celtra Duo CAD, respectively. It could be concluded that the effect of bleaching on color and microhardness was mainly material-dependent. Bleaching significantly affected the microhardness of IPS e.max CAD and VITA ENAMIC. The color difference was within the clinically imperceptible range for IPS e.max CAD, while VITA ENAMIC and Celtra Duo CAD demonstrated perceptible color change.
Effect of Iron Limitation, Elevated Temperature, and Florfenicol on the Proteome and Vesiculation of the Fish Pathogen Aeromonas salmonicida

We analyzed the proteomic response of the Gram-negative fish pathogen A. salmonicida to iron limitation, an elevated incubation temperature, and the antibiotic florfenicol. Proteins from different subcellular fractions (cytosol, inner membrane, outer membrane, extracellular and outer membrane vesicles) were enriched and analyzed. We identified several iron-regulated proteins that were not reported in the literature for A. salmonicida before. We could also show that hemolysin, an oxidative-stress-resistance chaperone, a putative hemin receptor, an M36 peptidase, and an uncharacterized protein were significantly higher in abundance not only under iron limitation but also with an elevated incubation temperature. This may indicate that these proteins involved in the infection process of A. salmonicida are induced by both factors. The analysis of the outer membrane vesicles (OMVs) with and without applied stresses revealed significant differences in the proteomes. OMVs were smaller and contained more cytoplasmic proteins after antibiotic treatment. After cultivation with low iron availability, several iron-regulated proteins were found in the OMVs, indicating that A. salmonicida OMVs potentially have a function in iron acquisition, as reported for other bacteria. The presence of iron-regulated transporters further indicates that OMVs obtained from ‘stressed’ bacteria might be suitable vaccine candidates that induce a protective anti-virulence immune response.
Active Surveillance in Intermediate-Risk Prostate Cancer: A Review of the Current Data

Simple Summary AS is an option for the initial management of selected patients with intermediate-risk PC. The proper way to predict which men will have an aggressive clinical course or indolent PC who would benefit from AS has not been unveiled. Genetics and MRI can help in the decision-making, but it remains unclear which men would benefit from which tests. In addition, there are several differences between AS protocols in inclusion criteria, monitoring follow-up, and triggers for active treatment. Large series and a few RCTs are under investigation, and more research is needed to establish an optimal therapeutic strategy for patients with intermediate-risk PC. This study summarizes the current data on patients with intermediate-risk PC under AS, recent findings, and discusses future directions. Abstract Active surveillance (AS) is a monitoring strategy to avoid or defer curative treatment, minimizing the side effects of radiotherapy and prostatectomy without compromising survival. AS in intermediate-risk prostate cancer (PC) has increasingly become used. There is heterogeneity in intermediate-risk PC patients. Some of them have an aggressive clinical course and require active treatment, while others have indolent disease and may benefit from AS. However, intermediate-risk patients have an increased risk of metastasis, and the proper way to select the best candidates for AS is unknown. In addition, there are several differences between AS protocols in inclusion criteria, monitoring follow-up, and triggers for active treatment. A few large series and randomized trials are under investigation. Therefore, more research is needed to establish an optimal therapeutic strategy for patients with intermediate-risk disease. This study summarizes the current data on patients with intermediate-risk PC under AS, recent findings, and discusses future directions.
Prognostic factors of facial nerve function after vestibular schwannoma removal via translabyrinthine approach

Abstract Background: Prediction of facial function is a major concern when proposing surgery for patients with vestibular schwannoma (VS). Aims/objectives: To evaluate postoperative facial function of patients who underwent operation of VS via a translabyrinthine approach (TL), and to analyze factors that influence facial functions. Material and methods: A total of 91 VS patients, who were operated via a TL approach, between March 1997 and December 2016, were analyzed. Demographics, tumor-related factors, and operative findings were collected. Facial function was assessed according to the House-Brackmann (HB) grading system before surgery, immediately after surgery, and 1-, 3-, 6-months, and 1 year after surgery. Results: In cases of patients that had a tumor that extended to the CPA, an unsatisfactory facial outcome was noted in 12 (30.0%) patients. FN outcomes after tumor removal depend on tumor size (p = .040). Among FN-related factors, only the FN recovery timing was correlated with facial outcomes (p = .030). Univariable and multivariable analysis revealed that tumor size and the timing of FN recovery were significant as favorable prognostic factors for good facial outcomes. Conclusions and significance: Tumor size and the FN recovery timing are significant prognostic factors of facial outcome in VS patients who underwent operations via a TL approach.
Hypothermia-Mediated Apoptosis and Inflammation Contribute to Antioxidant and Immune Adaption in Freshwater Drum, Aplodinotus grunniens

Hypothermia-exposure-induced oxidative stress dysregulates cell fate and perturbs cellular homeostasis and function, thereby disturbing fish health. To evaluate the impact of hypothermia on the freshwater drum (Aplodinotus grunniens), an 8-day experiment was conducted at 25 °C (control group, Con), 18 °C (LT18), and 10 °C (LT10) for 0 h, 8 h, 1 d, 2 d, and 8 d. Antioxidant and non-specific immune parameters reveal hypothermia induced oxidative stress and immunosuppression. Liver ultrastructure alterations indicate hypothermia induced mitochondrial enlargement, nucleoli aggregation, and lipid droplet accumulation under hypothermia exposure. With the analysis of the transcriptome, differentially expressed genes (DEGs) induced by hypothermia were mainly involved in metabolism, immunity and inflammation, programmed cell death, and disease. Furthermore, the inflammatory response and apoptosis were evoked by hypothermia exposure in different immune organs. Interactively, apoptosis and inflammation in immune organs were correlated with antioxidation and immunity suppression induced by hypothermia exposure. In conclusion, these results suggest hypothermia-induced inflammation and apoptosis, which might be the adaptive mechanism of antioxidation and immunity in the freshwater drum. These findings contribute to helping us better understand how freshwater drum adjust to hypothermia stress.
MODIFICATION OF LINDUR STARCH (Bruguiera Gymnorrhiza L.) BY OXIDATION USING SODIUM HYPOCLORITE AND FERRO SULPHATE CATALYST

Lindur fruit (Bruguiera gymnorrhiza L.) is widely available in Indonesia and has a high carbohydrate content, so it has the potential to be developed as a new source of energy and starch. So far, the use of lindur fruit is still limited to substitute rice and snacks. Therefore, it is necessary to make efforts to increase the utilization of lindur fruit by processing it into lindur starch and its derivatives (modified starch). The properties of lindur starch need to be improved in order to have wider uses in the food and non-food industries. The purpose of this study was to modify lindur starch by oxidation using NaOCl with ferrous sulfate as a catalyst. In this study, the effect of sodium hypochlorite concentration (2%, 4%, 6%, and 8%) and ferrous sulfate concentration (0%, 0.1%, 0.2%, and 0.3%) on the physicochemical characteristics of starch was studied. the resulting oxidized leachate and determined the optimal conditions. The results showed that all the variables studied affected the oxidation reaction of lindur starch. Oxidation at 4% NaOCl concentration and 0.2% ferrous sulfate concentration was able to produce the best values for carboxyl content, solubility, and swelling.
The effect of Surface Traps on the Interfacial Charge Dynamics in Layered Dielectrics

Space charge is a matter of concern in HVDC applications, causing considerable stress enhancement and consequent degradation. Apart from space charge within the volume of the insulation, interfacial charge at a multidielectric interface further aggravates the stress. The difference in permittivity and conductivity of the different dielectrics used in a composite insulation system are primarily responsible for interfacial charge. However, surface conditions and trap characteristics at the dielectric-dielectric interface have a significant role to play, and neglecting these effects would lead to erroneous estimation of interfacial charge, and poor insulation design. Hence, an improved charge transport model is proposed in this paper to model the charge dynamics at dielectric-dielectric interfaces. The effect of surface traps on a $300 \mu \mathrm{m}2$-layer LDPE is studied through space charge data obtained from Pulsed Electro Acoustic (PEA) measurements.
Pension Fund Trading Behavior and the Index Inclusion: Evidence from the Korean Stock Market

ABSTRACT In this paper, we study the trading effect of Korean pension funds on price change around index inclusions. We find that pension funds strategically respond to index composition changes, and their demand for newly included stocks is high and persistent. The liquidity providers for the demand of pension funds are individual investors. We also find the significant and positive effect of pension funds’ trading on newly included stocks’ prices following the announcement date. On the other hand, we could not find evidence of a positively persistent relationship between the trades of different types of investors and newly added stock returns. Overall, our findings highlight that the trading of pension funds can be an important explanatory factor for the index inclusion effects.
Electrochemical Enzyme Biosensor Bearing Biochar Nanoparticle as Signal Enhancer for Bisphenol A Detection in Water

An electrochemical tyrosinase enzyme (Tyr) biosensor using a highly conductive sugarcane derived biochar nanoparticle (BCNP) as a transducer and signal enhancer (BCNPs/Tyr/Nafion/GCE) was developed for the sensitive detection of bisphenol A (BPA). The BCNPs/Tyr/Nafion/GCE biosensor exhibited improved amperometric current responses such as higher sensing signal, decreased impedance and lowered reduction potential compared with the Tyr/Nafion/GCE due to high conductivity property of the biochar nanoparticle. Under the optimized conditions, it could detect BPA in good sensitivity with linear range from 0.02 to 10 μM, and a lowest detection limit of 3.18 nM. Moreover, it showed a low Km value, high reproducibility and good selectivity over other reagents, and the BCNPs/Tyr complex solution also showed good stability with 86.9% of sensing signal maintained after one month storage. The biosensor was also successfully utilized for real water detection with high accuracy as validated by high performance liquid chromatography. Therefore, the biochar nanoparticle based enzyme biosensor proved to be a potential and reliable method for high performance detection of pollutants in the environment.
Online continuing medical education in Mongolia: needs assessment

Purpose Due to the shortage in the healthcare workforce, insufficient qualifications, a lack of infrastructure and limited resources in Mongolia, it is not always possible for healthcare workers in rural areas who wish to attend continuous training and retraining courses to do so. However, in order to provide high-quality care, the demand for distance learning and the upgrading of knowledge and practice of many medical topics (especially related to morbidity and mortality) are necessary for the rural population. This study aimed to assess the needs of e-learning medical education, of graduates in Mongolia. Methods A cross-sectional research design was implemented. We collected data from 1,221 healthcare professionals (nursing professionals, physicians, midwives, and feldshers) who were randomly selected from 69 government hospitals in Mongolia. Data were collected using self-assessment questionnaires which captured the needs assessment in a survey for online continuous medical education in Mongolia. Data were analyzed using descriptive statistics and Kruskal-Wallis statistical test. Results Ninety percent of the respondents reported that they plan on attending online continuous medical education with the most preferred specialty area being emergency medicine. Results using the Kruskal-Wallis statistical technique suggested the preferred specialty area, educational content, appropriate time schedule, available devices, and tools were statistically significant and were different between the nursing professionals, physicians, midwives, and feldshers (p<0.05). Conclusion Findings provide important evidence for the implementation of measures and strategies which can assist healthcare professionals in low and middle-income areas/countries to constructively address their need for enhanced knowledge and practice through distance learning.
Antimicrobial Resistance, Biocide Tolerance, and Bacterial Diversity of a Dressing Made from Coriander and Parsley after Application of Treatments Using High Hydrostatic Pressure Alone or in Combination with Moderate Heat

The effects of high-hydrostatic pressure (HP) treatments (450 and 600 megapascals, MPa, for 5 min at temperatures of 22 °C and 50 °C) on the microbiota of a coriander and parsley dressing was studied via culture-dependent and culture-independent approaches. Samples were refrigerated for 20 days, with periodic counts of the culture media supplemented with, or without, antimicrobials. HP-treated samples showed significantly lower viable cell counts compared to untreated controls. Only the control samples yielded bacterial growth on media with antimicrobials (imipenem, cefotaxime, benzalkonium chloride), including mostly Pseudomonas and Lactobacillus. Bacillus and Paenibacillus were identified from pressurized samples. Few isolates showed higher tolerance to some of the biocides tested. Pseudomonads showed outstanding resistance to meropenem and ceftazidime. According to high-throughput sequencing analysis, the microbiota of the dressing control samples changes during storage, with a reduction in the relative abundance of Proteobacteria and an increase in Firmicutes. The composition of the residual microbiota detected during storage was highly dependent on the pressure applied, and not on the treatment temperature.
Assessment of wind turbine transient overvoltages when struck by lightning: experimental and analytical study

This paper is aimed at presenting a numerical method for calculating the transient overvoltage across a wind turbine (WT) struck by lightning. The resulting overvoltage is determined at different points along the WT body using the proposed numerical method. The lightning strike has been simulated by injecting a current impulse to the tested WT. The equivalent circuits of WT components and the mathematical formulas to evaluate the circuit's parameters are presented. This makes it possible to develop π-equivalent RLC networks representing the WT components to write the nodal equations at each discrete time instant. MATLAB software package is used to solve the nodal equations and determine the transient behaviour of the WT. In the laboratory, a high impulse voltage is applied on a small-scale WT to corroborate the proposed method. The calculated overvoltage temporal variations are in good agreement with those measured at different positions along the WT for various grounding resistance values, demonstrating the validity of the proposed method. Further validation is also made by comparing the present simulation with that using PSCAD/EMTDC software package. The overvoltage values increase with the rise of the grounding resistance value. The obtained results are useful for designing WT lightning protection systems.
Relationship of the neurovascular structures of the infratemporal fossae in black Zimbabweans: A cadaveric study

The Maxillary Artery (MA) is known to vary in its relationship to lateral pterygoid muscle (LPM) and its relationship to inferior alveolar nerve (IAN) and lingual nerve (LN). The variation poses surgical challenges and complications in anesthetic injection. This cadaveric study sought to describe the anatomy of the inferior alveolar nerve, lingual nerve and maxillary artery in infratemporal fossa and its associated variations. Thirty hemi- sections from 15 male cadavers were used. Dissection of the infratemporal fossae was done to expose the MA, LPM, IAN and LN. The relationship of MA to LPM was noted, roots of IAN were noted and relationship of structures were scrutinized. Pictures were taken for further analysis. Out of 30 hemi-sections, dissected 43.3% had a medial relationship to LPM while 56.7% of MA had a lateral relationship. Three (20%) of the cadavers showed asymmetry whereby MA passed on the medial side of LPM on one side while the other side it passed on the lateral aspect. Most of the hemi- sections (86.7%) had IAN originating with one (1) root, 3 hemi-sections (10%) with two roots and one (3.3%) with three roots. Only one hemi-section showed presence of a communicating branch between IAN and LN. The variations in MA in this population displays patterns comparable to other populations. There was high prevalence of MA passing lateral to LPM, which is consistent with studies done elsewhere. There were variations of IAN originating with multiple roots and presence of communicating branch between IAN and LN, which was consistent with case reports in literature.