Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychometric properties and domains of postural control tests for individuals with knee osteoarthritis: a systematic review

Individuals with knee osteoarthritis (OA) commonly demonstrate impaired postural control. We aimed to systematically review psychometric properties of tests that assess postural control in people with knee OA and secondly, to determine domains of postural control measured by these tests. PubMed, CINAHL, Embase and Web of Science databases were searched to January 2019. Two independent review authors screened references according to eligibility criteria. The Consensus-based Standards for the selection of health Measurement Instruments were used to evaluate study methodological quality. Postural control tests identified from included studies were assessed to determine postural control constructs using the Systems Framework for Postural Control identifying nine domains. Following the screening of 2643 references, five cross-sectional studies and one longitudinal study (n = 408) were included. Four studies evaluated reliability, validity or responsiveness of three clinical measures: Community Balance and Mobility Scale, Star Excursion Balance Test and Tinetti Performance Oriented Mobility Assessment. Two assessed reliability or validity of a force platform. Results showed that evidence for reliability, validity and responsiveness of all these postural measures is limited. The most common domain of postural control assessed was ‘static stability’. No study used measures that evaluated all nine postural control domains. Our results highlight limited investigation of psychometric properties specific to postural control in knee OA. The few existing ones have limitations regarding psychometric robustness and completeness regarding different domains of postural control. Future research should focus on verifying the quality of existing tools to evaluate postural control in knee OA for research and clinical purposes.
VALIDATION OF A NOVEL PARTIAL REBOA DEVICE IN A SWINE HEMORRHAGIC SHOCK MODEL: FINE TUNING FLOW TO OPTIMIZE BLEEDING CONTROL AND REPERFUSION INJURY.

OBJECTIVES Partial restoration of aortic flow during REBOA is advocated by some to mitigate distal ischemia. Our lab has validated the mechanics and optimal partial REBOA flow rates using a prototype device (pREBOA). We hypothesize that pREBOA will increase survival when compared to full REBOA (fREBOA) in prolonged non-operative management of hemorrhagic shock. METHODS 20 swine underwent placement of aortic flow probes, zone 1 REBOA placement, and 20% blood volume hemorrhage. They were randomized to either solid organ (SOI) or abdominal vascular (AVI) injury. The pREBOA arm (10 swine) underwent full inflation for 10min, then deflation to a flow rate of 0.5L/min for 2hr. The fREBOA arm (10 swine) underwent full inflation for 60min, followed by deflation/resuscitation. The primary outcome is survival, secondary outcomes are serologic/pathologic signs of ischemia-reperfusion injury and quantity of hemorrhage. RESULTS 2/10 swine survived in the fREBOA group (2/5 SOI, 0/5 AVI) v. 7/10 surviving in the pREBOA group (3/5 SOI, 4/5 AVI). Survival was increased (p=.03) and hemorrhage was higher in the pREBOA group (SOI 1.36±.25kg v. 0.70±.33kg, p = 0.007; 0.86±.22kg v. 0.71±.28kg, not significant). Serum evidence of ischemia was greater with fREBOA, but this was not significant (e.g. Lactate 16.91±3.87 mg/dL v. 12.96±2.48 mg/dL at 120min, not significant). Swine treated with pREBOA that survived demonstrated trends towards lower ALT, lower potassium, and higher calcium. The potassium was significantly lower in survivors at 60min and 90min time points (5.97±0.60 v. 7.53±0.90, p=.011; 6.67±0.66 v. 8.15±0.78, p=.029). Calcium was significantly higher at 30min, 60min, 90min (8.56±0.66 v. 7.50±0.40, p=.034; 8.63±0.62 v. 7.15±0.49, p=.019; 8.96±0.64 v. 7.00, p=.028). CONCLUSION Prolonged pREBOA at a moderate distal flow rate provided adequate hemorrhage control, improved survival, and had evidence of decreased ischemic injury versus fREBOA. Prophylactic aggressive calcium supplementation may have utility prior to and during the reperfusion phase. STUDY TYPE Basic Science (Original Article) LEVEL OF EVIDENCE: III.
Use of primary health care and participation in colorectal cancer screening – a Danish national register-based study

Colorectal cancer is the third most common cancer type and the second most common cancer-related death worldwide [1]. High incidence and mortality of colorectal cancer and effective screening tools have motivated nationwide immunochemical fecal occult blood test (iFOBT)-based colorectal cancer screening in many countries, including Denmark [1,2]. The benefit from the program depends largely on the participation rates and despite Danish free-of-charge screening, almost 40% choose not to participate [3]. Known facilitators of colorectal cancer screening include older age, high socioeconomic position, being married, Western ethnicity, and metropolitan residence [4–8]. Individuals who have frequent contact with the general practitioners and dentists have been found more likely to participate in colorectal cancer screening [4,5,9,10]. Whether this applies to other medical specialties and in a Danish context, is unknown. Studies have shown that the use of psychiatrists is associated with nonparticipation for women in cervical cancer and breast cancer screening [11–14], but whether this association is present in colorectal cancer screening, which includes both men and women, also remains unknown. To bring new insight into how non-participants in colorectal cancer screening could be identified and targeted, we assess associations between the use of primary health care and participation in colorectal cancer screening by 18 different medical specialties in Denmark; with special emphasis on visits to general practitioners, dentists, and psychiatrists.
Exploring Sex Differences in the Association between Bullying Involvement and Alcohol and Marijuana Use among U.S. Adolescents in 6th to 10th Grade

Abstract Objectives: The aim of the current study was to examine whether different types of involvement in bullying, together with a set of social-ecological correlates, were associated with alcohol and marijuana use for female and male adolescents. Methods: This study utilized data derived from the U.S. division of the 2005–2006 Health Behavior in School-Aged Children (HBSC) study, which include 7,084 U.S. 6th–10th graders (3,353 males and 3,731 females) in public and private schools. Results: The results showed that although some forms of involvement in bullying were associated with alcohol and marijuana use, some of these associations became non-significant when the social-ecological covariates were included in the models. The final logistic regression models revealed that being a traditional bully-victim increased the risk of alcohol use for males while being a traditional bully and cyber victim increased the risk of alcohol use for females. In addition, being a cyberbully increased the risk of marijuana use for males. While parental monitoring decreased the risk, delinquent peers increased the risk of both alcohol and marijuana use for both sexes. Parent/guardian support decreased the risk of alcohol use for females. The likelihood of alcohol use and marijuana use increased with age for both sexes, while being an African American was linked with a lower risk of alcohol and marijuana use among males. Conclusions/Importance: Our findings demonstrate the importance of examining the link between bullying involvement and substance use, together with social-ecological correlates for female and male adolescents.
Seroprevalence and Risk Factors of Cystic Echinococcosis among Children in Lorestan Province, Western Iran

Hydatidosis is as a zoonotic disease can be transmitted to human by consumption of the parasite’s eggs through vegetables, water, food and also via having contact with dog. Children because of contact with the animals and lack of hygiene standards in the consumption of food, water, fruits and vegetables are far more at risk of hydatidosis. This study was aimed to evaluate seroprevalence and risk factors Cystic echinococcosis (CE, hydatid cyst) in children (2-15 year old) referred to health centers of Lorestan province, Iran. This cross-sectional study was performed from August 2016 to March 2017 on 316 children (aged 2-15 years), referring to health centers of Lorestan province, Iran. All the serum samples were tested using the commercially ELISA kit of NovaLisa® Echinococcus IgG (Novatec, Germany) according to the manufacturer's instructions. Statistical analysis was carried out using SPSS 17.0 software. Multifactorial logistic regression models were applied to determine association between CE seropositivity and the potential risk factors. Of the 316 children, 9 (2.84%) tested seropositive for anti-hydatid IgG antibody. In multifactorial logistic regression models, some risk factors such as living in rural regions (4.3; 90% CI: 1.9-9.6) and contact with dogs (3.8; 90% CI: 1.7-8.9) were significantly related to seropositivity to anti-hydatid IgG antibodies. To conclude, we found that CE is prevalent among in children referred to health centers of Lorestan province, Iran. The obtained findings may be a warning for health centers to pay special attention to CE among children and also design screening programmers for prevention of CE.
Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER)

Background: Five percent of adult patients undergoing noncardiac inpatient surgery experience a major pulmonary complication. The authors hypothesized that the choice of neuromuscular blockade reversal (neostigmine vs. sugammadex) may be associated with a lower incidence of major pulmonary complications. Methods: Twelve U.S. Multicenter Perioperative Outcomes Group hospitals were included in a multicenter observational matched-cohort study of surgical cases between January 2014 and August 2018. Adult patients undergoing elective inpatient noncardiac surgical procedures with general anesthesia and endotracheal intubation receiving a nondepolarizing neuromuscular blockade agent and reversal were included. Exact matching criteria included institution, sex, age, comorbidities, obesity, surgical procedure type, and neuromuscular blockade agent (rocuronium vs. vecuronium). Other preoperative and intraoperative factors were compared and adjusted in the case of residual imbalance. The composite primary outcome was major postoperative pulmonary complications, defined as pneumonia, respiratory failure, or other pulmonary complications (including pneumonitis; pulmonary congestion; iatrogenic pulmonary embolism, infarction, or pneumothorax). Secondary outcomes focused on the components of pneumonia and respiratory failure. Results: Of 30,026 patients receiving sugammadex, 22,856 were matched to 22,856 patients receiving neostigmine. Out of 45,712 patients studied, 1,892 (4.1%) were diagnosed with the composite primary outcome (3.5% sugammadex vs. 4.8% neostigmine). A total of 796 (1.7%) patients had pneumonia (1.3% vs. 2.2%), and 582 (1.3%) respiratory failure (0.8% vs. 1.7%). In multivariable analysis, sugammadex administration was associated with a 30% reduced risk of pulmonary complications (adjusted odds ratio, 0.70; 95% CI, 0.63 to 0.77), 47% reduced risk of pneumonia (adjusted odds ratio, 0.53; 95% CI, 0.44 to 0.62), and 55% reduced risk of respiratory failure (adjusted odds ratio, 0.45; 95% CI, 0.37 to 0.56), compared to neostigmine. Conclusions: Among a generalizable cohort of adult patients undergoing inpatient surgery at U.S. hospitals, the use of sugammadex was associated with a clinically and statistically significant lower incidence of major pulmonary complications. In a multicenter observational matched cohort study of noncardiac surgery, sugammadex administration was associated with a 30% reduced risk of pulmonary complications, a 47% reduced risk of pneumonia, and a 55% reduced risk of respiratory failure compared to neostigmine. Supplemental Digital Content is available in the text.
A congruence perspective on how human and social capital affect learning capability and innovation

Human capital and social capital are vital for sustainable development of organization, but existing studies are inadequate to explore the synergistic effect of them on organizational behaviors or organizational outcomes. The research employed multiple-source questionnaire to collect data of more than 400 R&D firms from leaders and corresponding employees in Chinese context. Bootstrapping method and response surface were used to analyze the associations between all the parameters. The results showed that: (1) in the case of the in-congruence between human capital and social capital, learning capability of R&D firms is at highest level when human capital is at low level and social capital is at high level; (2) learning capability partially mediates the impact of human capital and social capital on innovation performance; (3) environmental dynamism and environmental competitiveness have a joint moderating effect on the relationship between learning capability and innovation performance.
Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis: a pilot study

Abstract Objectives: Research evidence suggests that chronic pouchitis is associated with intestinal dysbiosis. Faecal microbiota transplantation (FMT) has been proposed as a possible treatment. We performed a 6-month prospective, open-label, single-centre cohort pilot-study (NCT03538366) to investigate if FMT could improve clinical outcome and alter gut microbiota in patients with chronic pouchitis. Materials and methods: Nine adult patients with chronic pouchitis were included and allocated to 14 days FMT by enemas from five faecal donors, with a 6-month follow-up. Pouchitis severity was assessed using pouchitis disease activity index (PDAI) before and after FMT. Changes in gut microbiota, and engraftment of donor’s microbiota were assessed in faecal samples. Results: All patients were treated with FMT for 14 continuous days. Overall, four of nine patients receiving FMT were in clinical remission at 30-day follow-up, and three patients remained in remission until 6-month follow-up. Clinical symptoms of pouchitis improved significantly between inclusion and 14-day follow-up (p = .02), but there was no improvement in PDAI between inclusion (mean 8.6) and 30-day follow-up (mean 5.2). Treatment with FMT caused a substantial shift in microbiota and increased microbial diversity in six patients, resembling that of the donors, with a high engraftment of specific donor microbiota. Conclusions: Symptomatic benefit in FMT treatment was found for four of nine patients with chronic pouchitis with increased microbial diversity and high engraftment of donor’s microbiota. A larger, randomised controlled study is required to fully evaluate the potential role of FMT in treating chronic pouchitis.
Comparison of the ruminal and fecal microbiotas in beef calves supplemented or not with concentrate

Most of the research efforts involving the bovine gastrointestinal microbiota have focused on cattle’s forestomach, particularly the rumen, so information concerning the bovine fecal microbiota is more scarce, especially in young beef cattle. The present study was performed to evaluate the ruminal and fecal microbiotas of beef calves as they reached the end of their nursing phase. A total of 18 Angus cow/calf pairs were selected and assigned to one of two treatment groups for the last 92 days of the calves’ nursing period, as follows: 1) calves were supplemented with concentrate in a creep feeding system; or 2) control group with no supplementation of calves. After 92 days, ruminal and fecal samples were individually obtained from calves in both groups, and their microbiotas were evaluated using 16S rRNA gene sequencing. Ruminal samples were predominated by Prevotella (18 to 23% of the total bacterial abundance), regardless if calves received supplementation or not; however, in the feces, Prevotella was only the seventh most abundant genus (0.6 to 2.1% of total bacterial abundance). Both the rumen (P = 0.01) and the feces (P = 0.05) of calves that received supplementation had greater abundance of Firmicutes. In addition, calves that were supplemented had lower abundance of Fibrobacteres (P = 0.03) in their rumens. Regardless if the calves were supplemented or not, Faith’s Phylogenetic Diversity index (P ≤ 0.007) and total concentration of short chain fatty acids (P < 0.001) were both greater in the rumen than in the feces of calves. In summary, the ruminal and fecal microbiotas of weanling beef calves were considerably distinct. Additionally, supplementation with creep feed caused some significant changes in the composition of the gastrointestinal microbiota of the calves, especially in the rumen, where supplementation caused an increase in Firmicutes and a decrease in abundance of Fibrobacteres.
Prevalence and Risk Factors of Extended Spectrum Beta-Lactamase-Producing Uropathogens among UTI Patients in the Governmental Hospitals of North West Bank: A Cross-Sectional Study

Background: Urinary tract infections caused by Extended Spectrum Beta-Lactamase producing organisms (UTI-ESBL) are increasing in incidence and pose a great threat to modern medicine. The objective of this study was to assess the prevalence and risk factors of Extended Spectrum Beta-Lactamase (ESBL)-producing uropathogens among patients with urinary tract infections in the north of West Bank and to determine the antimicrobial susceptibility profile of the isolated bacteria. Methods: A total of 427 patients who were attending the governmental hospitals in the northern cities of the West Bank were included in the study. They were older than 12 years and diagnosed with UTI in the period from June 2017 to September 2017. Isolated bacteria was collected from the microbiology labs of the respective hospitals and tested for the ESBL production and their antibiotic susceptibilities were determined. Information regarding the risk factors was collected from the patient's medical records. Univariate analyses were performed for potential risk factors for the development of UTI-ESBL, and then multivariate analyses were performed for all significant variables. Results: Out of the 427 urine cultures screened for ESBL, 163 (38.4%) were confirmed to be ESBL producers. E. coli was the most frequent uropathogen. K. pneumoniae produced the highest rate of ESBL (54.9%), followed by E. coli (42.5%), and Proteus mirabilis (7.14%). Patients with recurrent UTI had 5 times relative risk of having ESBL producing uropathogens (odd ratio (OR), 4.7) followed by previous antibiotic use (OR, 3.07), hemodialysis (OR, 2.92), chronic kidney disease (OR, 2.69) and finally diabetes mellitus (OR, 1.87). ESBL isolates were susceptible to fosfomycin (100%), nitrofurantoin (93.9%), pipracillin/tazobactam (94.5%), ertapenem (98.2%), meropenem (98.8%), and amikacin (93.9%). Conclusion: The prevalence of ESBL-producing uropathogens was 38.4%. Recurrent UTI appeared to be the strongest risk factor for ESBL-UTI. ESBL–producing uropathogens were highly susceptible to amikacin, nitrofurantoin, and much more to fosfomycin and piperacillin/tazobactam in addition to carbapenems.
Insights into Lithium and Sodium Storage in Porous Carbon.

The lithium and sodium storage behavior of the porous carbons remains controversial though they show excellent cycling stability and rate performances. This letter discloses the insertion, adsorption and filling properties of a porous carbon. The 7Li nuclear magnetic resonance (NMR) spectroscopy recognized inserted and adsorbed lithium in this porous carbon but did not observe any other forms of lithium above 0.0 V vs. Li+/Li. In addition, although lithium insertion mainly takes place at low potentials, adsorption was found to be the main form of lithium storage throughout the investigated potential range. Such storage feature is responsible for the excellent rate performance and high specific capacity of the porous carbon. The Raman spectroscopy further demonstrated the structural reversibility of the carbon in different potential ranges, verifying the necessity to optimize the potential range for a better cycling performance. These findings provide insights for the design and application of porous carbons.
Vestibular migraine - an underdiagnosed cause of vertigo. Diagnosis and treatment.

INTRODUCTION Migraine and vertigo are two common conditions. The main disorder connecting both these entities is vestibular migraine (VM). STATE OF THE ART VM may affect 1-3% of the general population. It is a disabling disease of recurrent attacks of vestibular symptoms accompanied by migraine features which occur in patients with a current or previous history of migraine. The episodes can last minutes, hours or even days, and may occur without any concurrent headache, which can prompt misdiagnosis. VM often begins several years after a typical migraine, and the delay between onset of headache and vertigo may be long. The diagnosis is based on the patient's clinical history and can be challenging due to the lack of an established confirmatory diagnostic test or biomarkers. The mechanism of vestibular migraine remains unclear and is still under investigation, but it seems to be an interaction between trigeminal and vestibular systems. Due to the lack of specific trials, treatment recommendations are based on migraine guidelines. Several drugs seem to be effective, although there have been few randomised controlled trials in this area. Regardless of the published strict and detailed diagnostic criteria, this condition remains little known, and as a consequence is underdiagnosed and undertreated. CLINICAL IMPLICATIONS Efforts should be made to educate medical communities and patients about this disease and to encourage neurologists and ENT specialists to cooperate. Every patient with vertigo of unknown origin should be directly asked about a past or present history of migraine, or migraine symptoms experienced during their vertigo episodes. FUTURE DIRECTIONS There is a growing need for studies regarding the pathophysiology of VM as well as randomised trials to establish clear treatment recommendations and to improve management of this surprisingly common disorder.