Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation of Salmonella enterica Serovar Typhimurium mntH Transcription by H 2 O 2 , Fe 2 (cid:1) , and Mn 2 (cid:1)

MntH, a bacterial homolog of mammalian natural resistance associated macrophage protein 1 (Nramp1), is a primary transporter for Mn 2 (cid:1) inﬂux in Salmonella e nterica serovar Typhimurium and Escherichia coli. S. enterica serovar Typhimurium MntH contributes to H 2 O 2 resistance and is important for full virulence. Consistent with its phenotype and function, mntH is regulated at the transcriptional level by both H 2 O 2 and substrate cation. We have now identiﬁed three trans -acting regulatory factors and the three corresponding cis -acting mntH promoter motifs that mediate this regulation. In the presence of hydrogen peroxide, mntH is activated by OxyR, acting through an OxyR-binding motif centered just upstream of the likely (cid:2) 35 RNA polymerase-binding site. In the presence of Fe 2 (cid:1) , mntH is repressed primarily by Fur, acting through a Fur-binding motif overlapping the (cid:2) 35 region. In the presence of Mn 2 (cid:1) , mntH is repressed primarily by the Salmonella equivalent of E. coli b0817, a distant homolog of the Bacillus subtilis manganese transport repressor, MntR, acting through an inverted-repeat motif located between the likely
Investigating the Usefulness of TikTok as an Educational Tool

— Living in a modern world requires educators to acquire skills in integrating technology into classroom activities to make the lessons more viable and fun for our generation Y and Z. There are a variety of new applications which can be used by educators as educational tools. This research aims to investigate the usefulness of Tik Tok as an educational tool and to gather students’ feedback after using the TikTok application in their listening comprehension. The overall response to the survey was promising as most of the respondents gave positive feedback on the use of this application in their language learning process. Thus, the insights provided by this study on the usefulness of TikTok can be a guide for educators as well as policymakers aiming at exploring new educational tools to ease the teaching and learning process.
Systematic reviews and evidence synthesis: Resources beyond the health sciences

Asystematic review is a type of review that “seeks to systematically search for, appraise and synthesis research evidence,” 1 including results published in grey literature. For decades, systematic reviews have been widely used to synthesize evidence in the health sciences. More recently, other disciplines, such as agriculture and the social sciences, have seen a rise in systematic reviews and related research methodologies. In response to this development, both Cornell University 2 and the University of Minnesota Libraries 3 have launched systematic review services that explicitly cater to non-health-sciences researchers at their institutions. Because it is recommended that librarians play a part on systematic review teams, 4 there is a need for resources and skill development in this area.
RMHP_A_254625 1069..1077

1Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Armauer Hansen Research Institute, Addis Ababa, Ethiopia; 3College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 4School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia Introduction: Leprosy or Hansen’s disease is a potentially disabling disease that results in discrimination and self-stigma. A delay in case detection among leprosy patients is one of the factors resulting in disability. Although poor insights of the community toward leprosy lead to delays in case detection, studies on such matters are neglected in Ethiopia. Objective: To assess the level of community knowledge and attitudes toward leprosy in Fedis District, Eastern Ethiopia. Methods: A community-based cross-sectional study was carried out among 728 randomly selected households from July to August 2019. Each participant was interviewed using a pretested structured questionnaire consisting of participants’ socio-demographic background, questions related to knowledge of and attitudes toward leprosy. The collected data were entered using EpiData 3.1 and analyzed using STATA version 13. Chi-squared test, binary, and multivariable logistic regressions were applied as appropriate to assess the association between outcome and independent variables. Results: Among 728 study participants, 608 (83.52%) of them had heard about leprosy. Among the study participants who had heard of leprosy, 346 (56.91%) of them had high knowledge of leprosy. Multivariable logistic regression revealed that study participants who completed grade 1–8 (AOR=1.68, 95% CI=1.09–2.58, P=0.017) and government employees (AOR=7.56, 95% CI=2.23–25.63, P=0.001) were significantly associated with high level of knowledge of leprosy. Out of 608 study participants who had heard of leprosy, only 248 (40.79%) had a favorable attitude toward leprosy. Study participants who completed grade 1–8 (AOR= 2.72, 95% CI=1.76–4.19, P= 0.000) and urban inhabitants (AOR=0.49, 95% CI=0.31–0.75, P= 0.032) were significantly associated with favorable attitude toward leprosy. Having high knowledge of leprosy was significantly associated with favorable attitudes toward leprosy. Conclusion: This study revealed unfavorable attitudes toward leprosy among the community. Having a high overall knowledge level on leprosy has been shown to support a favorable attitude toward leprosy.
BIROn - Birkbeck Institutional Research Online developmental

Traditionally, developmental prosopagnosia (DP) has been thought of as an apperceptive condition that hinders individuals’ ability to encode face structure. However, several authors have recently raised the possibility that many DPs may be able to form accurate percepts, but be unable to maintain those percepts over time. The present study sought to distinguish these possibilities. In our first experiment 16 DPs and 22 typical controls completed a delayed match-to-sample task with face and car stimuli, with a retention interval of 1-second (low demand) or 6-seconds (high demand). As expected, the participants with DP were worse than the controls at face matching, and were disproportionately impaired at matching faces relative to cars. However, the relative degree of impairment seen in the DPs did not interact with retention interval; they exhibited similar levels of impairment when matching faces with 1- and 6-second delays. Next, we compared the performance of 72 DPs and 54 typical controls on the Cambridge Face Perception Test (CFPT), a task that measures face perception ability in a way that minimises the memory demands. As expected, we found that the DPs were impaired at the group level. This difference was not attributable to a few individuals with an apperceptive profile; rather we found evidence that the distribution of CFPT scores seen in the DP sample was shifted relative to that of typical controls. Some heterogeneity is likely in any neurodevelopmental population, and DP is no different. Generally, however, these findings suggest that selective STFM impairment may be relatively uncommon in this population. Instead, deficits of perceptual encoding may play a larger role in DP than currently acknowledged.
Maternal mental health and caregiver competence of HIV-positive and negative women caring for their singleton newborns in KwaZulu-Natal Province, South Africa.

BACKGROUND Maternal mental health during the perinatal period has been of interest to many researchers, with antenatal depression and postnatal depression (PND) being a leading cause of morbidity. The adverse effects of maternal depression on the offspring throughout infancy, childhood and adolescence are well documented. Studies on the mental health of persons living with HIV have also reported a high prevalence of depression. OBJECTIVES To describe the prevalence of PND in a sample of HIV-positive and HIV-negative mothers delivering healthy singleton infants at one obstetric unit in KwaZulu-Natal (KZN) Province, South Africa, and the subsequent factors influencing neonatal behaviour and perceptions of caregiver competence. Correlations between the presence of PND and perceptions of caregiver competence (with the mother as caregiver), and between infant behaviour, the mother's confidence in her competence as caregiver, and demographic and medical variables, were also examined. METHODS Demographic and clinical data were collected from 132 mothers at initial contact and from 32 mothers at the 6-week follow-up appointment. Mothers independently completed the Edinburgh Postnatal Depression Scale at each time point, and the Mother and Baby Scales (MABS) at the 6-week follow-up appointment. RESULTS The prevalence of depression among all mothers at initial contact was 72.0%, remaining high (68.8%) among the mothers who returned for follow-up. There was a statistically significant correlation between depression and employment at follow-up (p=0.013), and between depression and delivery method (p=0.030). The majority of mothers reported being 'able to laugh and see the funny side of things' and 'looking forward with enjoyment to things' at initial contact and follow-up. Thoughts of self-harm were reported by 44.7% of mothers at baseline, and by 53.1% at follow-up. Although most infants scored in the average clinical band for neonatal behavioural factors in the MABS, mothers reported lack of confidence, globally and in caring for their infant. CONCLUSION This study of maternal mental health of a sample of HIV-positive and HIV-negative mothers of infants in KZN revealed a higher prevalence of PND than reported in other studies. This population of mothers and infants is at risk of adverse outcomes of maternal depression, in addition to other possible risk factors.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PENERIMAAN PENGGUNAAN PERSONAL COMPUTER DENGAN TECHNOLOGY ACCEPTANCE MODEL

The objectives of the research are to examine some factors that influence personal computer acceptance from user in manufacture company. The study is based on the model proposed by Venkatesh et al . ,(2003) and Lin and Wu (2004) . This study used data that obtained from individual perception of information sistem user in manufacture company at Surakarta. Data gathered from mail survey. Three hundred questionnaires have sent to companies, 105 questionnaires were returned, and only 83 questionnaires can be used. The data were analyzed by using Partial Least Square (PLS) by Smart PLS software. Study results show that social influence give insignificant negative to attitude toward using PC. Perceived ease of use give significant positive to perceived usefullnes and attitude toward using PC. Perceived usefullnes give significant positive to attitude toward using PC. Attitude toward using PC give significant positive to personal computer acceptance. Management support give significant positive to perceived usefullnes and perceived ease of use
Joint Search over the Life Cycle ∗

This paper studies how the added worker eﬀect - intra-household insurance through increased spousal labor market participation - varies over the life cycle. We show in U.S. data that the added worker eﬀect is much stronger for young than for old households. A stochastic life cycle model of two-member households with job search in a frictional labor market is capable of replicating this ﬁnding. The model suggests that a lower added worker eﬀect for the old is driven primarily by better insurance through asset holdings. Human capital diﬀerences between employed young and old contribute to the diﬀerence but are quantitatively less important, while diﬀerences in job arrival rates play a limited role.
Nitridergic Modulation of COX-2 Efficacy

Pain is a common unpleasant sensory and emotional experience, in which are frequently used in their treatment the nonsteroidal anti-inflammatory drugs (NSAIDs). A group of agents with antipyretic, analgesic, and anti-inflammatory properties due to the inhibition of cyclooxygenase enzymes (COXs). Among these drugs there are a group of selective inhibitors of COX-2 named coxib that include to parecoxib, celecoxib, rofecoxib and etoricoxib. Pharmacological information on the mechanism of action of coxibs is insufficient to determine the analgesic and anti-inflammatory efficacy of these agents. There are contradictory reports regarding the antinociceptive effects of the various coxibs at the preclinical level as well as the nitridergic modulation of such actions. The objective of the present study was to evaluate the antinociceptive efficacy of parecoxib, rofecoxib, celecoxib, and etoricoxib using the formalin hind paw assay in mice and the possible contribution of the nitridergic system in the efficacy of COX-2 agents. Antinociception was assessed in a murine formalin assay using dose-response curves to coxibs before and after i.p. administration of 5 mg/kg of L-NAME. Coxibs produced dose-dependent analgesia and anti-inflammation. L-NAME administration reduced the analgesic and anti-inflammatory effectiveness of parecoxib, rofecoxib, celecoxib, and etoricoxib. These findings suggest that the effect of these agents, in addition to COX-2 inhibition, would be mediated by other mechanisms, among which nitridergic modulation would be compromised.
Understanding recent tropospheric ozone trends in the context of large internal variability: a new perspective from chemistry-climate model ensembles

Observational records of meteorological and chemical variables are imprinted by an unknown combination of anthropogenic activity, natural forcings, and internal variability. With a 15-member initial-condition ensemble generated from the CESM2-WACCM6 chemistry-climate model for 1950–2014, we extract signals of anthropogenic (‘forced’) change from the noise of internally arising climate variability on observed tropospheric ozone trends. Positive trends in free tropospheric ozone measured at long-term surface observatories, by commercial aircraft, and retrieved from satellite instruments generally fall within the ensemble range. CESM2-WACCM6 tropospheric ozone trends are also bracketed by those in a larger ensemble constructed from five additional chemistry-climate models. Comparison of the multi-model ensemble with observed tropospheric column ozone trends in the northern tropics implies an underestimate in regional precursor emission growth over recent decades. Positive tropospheric ozone trends clearly emerge from 1950 to 2014, exceeding 0.2 DU yr−1 at 20–40 N in all CESM2-WACCM6 ensemble members. Tropospheric ozone observations are often only available for recent decades, and we show that even a two-decade record length is insufficient to eliminate the role of internal variability, which can produce regional tropospheric ozone trends oppositely signed from ensemble mean (forced) changes. By identifying regions and seasons with strong anthropogenic change signals relative to internal variability, initial-condition ensembles can guide future observing systems seeking to detect anthropogenic change. For example, analysis of the CESM2-WACCM6 ensemble reveals year-round upper tropospheric ozone increases from 1995 to 2014, largest at 30 S–40 N during boreal summer. Lower tropospheric ozone increases most strongly in the winter hemisphere, and internal variability leads to trends of opposite sign (ensemble overlaps zero) north of 40 N during boreal summer. This decoupling of ozone trends in the upper and lower troposphere suggests a growing prominence for tropospheric ozone as a greenhouse gas despite regional efforts to abate warm season ground-level ozone.
Credit Expansion and Markups

This article documents new empirical facts about the effects of credit expansion on the aggregate markup and markup dispersion in the United States. We use U.S. macroeconomic data and Jordà’s local projection and single-equation estimation methods. The results for both methods show that the aggregate markup and markup dispersion increase in response to both a firm debt shock and a household debt shock. The previous literature mostly focused on the effect of firm debt financing on firm markups. Extending previous research, our study shows that household credit expansion also plays a role in firm markups. This finding calls for further theoretical and analytical studies to understand the underlying mechanism regarding the effect of household credit expansion on firm markups. (JEL E31, E51, L11) St. Louis Fourth 297-316.
OPTH_A_372440 2429..2440

Purpose: To describe the early real-world experience of physicians with an intracanalicular dexamethasone insert (DEX) in patients undergoing cataract surgery and to capture the clinical impact of adopting this therapy. Patients and Methods: 23 United States sites including Ambulatory Surgical Center Setting (ASC) and Outpatient Clinical settings. Respondents were physicians who had early experience with DEX in cataract surgery patients. This was a Phase 4 experiential crosssectional survey study comprised of 3 sequential online physician surveys. Descriptive statistics summarized the surveys’ responses to determine the early impressions of the respondents. Results: Forty-two physicians completed surveys. On average, physicians reported feeling comfortable administering DEX after placing 3 inserts (mean 2.7; standard deviation 1.9). Most physicians (92%) were satisfied with DEX, and all physicians (100%) reported that DEX improved patient compliance. Most physicians (62.5%) indicated they would highly prefer DEX over traditional steroid eyedrops for the management of post-surgical inflammation and pain. Conclusion: The surveys exploring the early use of DEX suggest that DEX is a clinically effective treatment with a rapid initial learning curve and integrates well into clinical use. Physicians had a very positive early experience with DEX, including comfort with insertion and satisfaction. DEX shows promise as a primary treatment choice of physicians for ocular inflammation and pain following cataract surgery by offering patients a hands-free innovative therapy that delivers a preservative-free steroid to the ocular surface over approximately 30 days.
Why Do Anterior Cruciate Ligament Reconstruction Fail : Failure Rate and Causes

Objectives: The purpose of this study was to determine the failure rate and to analyse failure aetiology among patients who undergone primary ACL (anterior cruciate ligament) reconstruction with a description of our experience; as we have obtained good results in most of our patients. Methods: In our Sport Surgical Department between April 2012 and November 2018, we operated on 934 patients with single bundle ACL reconstruction. Surgeries were performed by one team composed of two experienced sport surgeons and two trained- fellows in sport surgery. A total of 54 patients (23 left knees and 31 right knees) were planned for ACL revision after evaluating them clinically and radiologically. Although there is debate about the definition of ACL, we defined failure as requiring revision if there was objective clinical failure that met one or more of the following: Lachman grade II or III, pivot shift grade II or III, KT-1000/2000 > 5 mm, and/or overall IKDC score C or D. Exclusion criteria included history of prior ACL reconstruction failure, presence of concomitant ligament injuries, and complex regional pain syndrome. Instability examination, CT and MRI were done for all patients that met our criteria for failure, and the data collected for all cases before revision surgery included graft type, tunnel drilling technique, graft fixation systems used, Lysholm score, subjective and objective IKDC scores and questionnaire (including whether a traumatic event was absent or present causing instability). Result: The failure rate of primary ACL reconstruction was 5.8%. Non-traumatic cause was responsible for the failure in 59.3% of cases, 25.9% due to technical error with aberrant femur tunnel was found as the most common (72.7%). There was significant correlation between non-anatomical femur tunnel and non-traumatic failed cases (P<0.05) . 40.9% of traumatic failed cases were also found to have technical error. Non-traumatic cause is responsible for early ACL revision with significant P-value ( p<0.05 ) and there was no significant graft failure difference between adjustable loop and interference screw graft fixation system ( P>0.05) . An elongated graft was the most common mode of graft failure pattern identified arthroscopically in 59.6% of cases. Conclusion: The best chance to achieve successful ACL reconstruction surgery is in primary index surgery with success rate more than 85%. However, awareness about aetiologies of failure that could considerably overlap is crucial. Non-traumatic causes might be the primary cause for the revision. Despite improvements in surgical techniques, fixation devices, and ACL anatomy, more effort may be needed to lessen the incidence of failure among studies.
Workshop on Computational Methods in the Humanities 2018 (COMHUM 2018)

The paper introduces TAG, a hypergraph data model for the modeling and processing of text. The features of a hypergraph allow for an inclusive and id-iomatic approach to humanities text, and support a wide range of research perspectives. Furthermore, editing texts as hyper-graphs gives touches upon pivotal issues regarding our understanding of text
Evaluation of One-Dimensional Multi-Directional Site Response Analyses Using Geotechnical Downhole Array Data in California and Japan

This study presents a comprehensive investigation of one-dimensional (1-D) site response analysis (SRA) to predict the dynamic response of soil deposits under earthquake loading utilizing the recordings at selected borehole arrays. Seven instrumented downhole arrays in California and Japan were studied using 41 recorded ground motions that cover a broad range of intensities. The arrays were initially assessed in terms of effectiveness of 1-D SRA using taxonomy screening. Furthermore, LS-DYNA, an advanced Finite Element (FE) program, was employed to develop the 1-D soil column models for the SRA of these arrays. The soil stress-strain behavior was characterized with three different models including one linear elastic and two nonlinear backbone curve formulations. All predictions were compared to the measured ground motions to quantify the model biases and uncertainties. Lastly, the practical limitations of 1-D SRA models considered herein are identified, and recommendations are provided to assess the usefulness of the predictions in engineering practice.
To Engage or Not : Identifying The Content Characteristics of Brand Instagram Stories That Impact Engagement Behaviour in Irish Consumers

5 Chapter 1: Introduction. 6 1.1: Literature Review. 7 2.2: Hypothesis Development. 11 Chapter 2: Methodology. 17 2.1: Participants. 17 2.2: Design. 20 2.3: Materials. 22 2.4: Procedure. 23 2.5: Ethics. 24 Chapter 3: Results. 27 3.1: Descriptive Statistics. 27 3.2: Inferential Statistics. 41 3.3: Reliability. 42 3.4: Conclusion. 43 Chapter 4: Discussion and Conclusion. 44 4.1: Discussion. 44 4.2: Strengths and Limitations. 48 4.3: Future Research. 50 4.4: Recommendations for Business. 51 4.5: Conclusion. 52 Bibliography. 53 Appendices. 59 Appendix A: Survey Questions . 59