Miracle-dz/UniFAR-FTUs huggingface dataset:
Addition of leukotriene receptor antagonists versus long acting beta agonists to inhaled corticosteroid therapy for asthma treatment in older adults: A retrospective data analysis of effectiveness, safety and cost

Asthma treatment is challenging in older adults. To date, there is no evidence from research with older adults to support choosing the most appropriate add-on treatment for inadequately controlled asthma, despite using inhaled corticosteroids (ICS). We retrospectively investigated the comparative effectiveness, cardiovascular (CV) safety and costs associated with ICS + leukotriene receptor antagonists (ICS+LTRA) versus ICS + long acting beta agonists (ICS+LABA) treatments. We included asthmatic Medicare beneficiaries aged 66 and older, who continuously enrolled in Fee for Service Medicare with Part D coverage, and treated with ICS+LABA or ICS+LTRA in an exclusive manner. This dissertation work was organized into two major studies. Firstly, effectiveness and CV safety outcomes were compared between the two treatments. The augmented inverse propensity weighted estimator was used to determine the effect of LABA vs. LTRA add-on therapy on asthma exacerbations requiring inpatient, emergency, or outpatient care as well as CV events, adjusting for several co-variables. Our results showed that LTRA add-on treatment was associated with increased odds of asthma-related hospitalizations/emergency department visits (OR=1.4, p<0.001), and outpatient exacerbations requiring oral corticosteroids or antibiotics (OR=1.41, p<0.001) compared to LABA treatment. LTRA add-on therapy also showed lower effectiveness in controlling symptoms as indicated by greater utilization of short-acting beta agonists (RR=1.58, p<0.001). On the other hand, LTRA add-on treatment was associated with lower odds of experiencing a CV event compared to LABA (OR=0.86, p=0.006). Secondly, multivariable regression models with nonparametric bootstrapped standard errors were employed to compare all-cause and asthma-related costs between the two treatment groups. The results showed that ICS+LTRA treatment was associated with increased asthma-related costs compared to ICS+LABA. With a mean of 1.06 person-years follow up, adjusted asthma-related costs were $4,724 for ICS+LTRA group vs $2,939 for ICS+LABA group (p<0.001). Total all-cause costs were not significantly different between treatment groups ($74,369 for ICS+LABA compared with $68,944 for ICS+LTRA (p=0.219)). Together, these findings provide new evidence specific to older adults to help health care providers weigh the risks and benefits of these add-on treatments. The economic evaluation conducted in this dissertation can enhance clinical decision-making and efficient evidence-based health practice in older adults.
Reference values of haematological parameters of healthy adults in the north central zone of Nigeria

Background: Haematological parameters differ from one population to another due to several factors. To determine the clinical implication of the blood parameters of an individual in the state of health or disease, we need to have the knowledge of the normal reference range for that locality. Objectives: To determine the reference values of haematological parameters of apparently healthy adults in Ilorin. Design: A descriptive cross sectional study. Setting: Ilorin, North Central zone of Nigeria Subjects: Nine hundred and ten (443 males and 467 females) randomly selected normal, HIV negative individuals aged 18-65 years Results: The red blood cell count, Haemoglobin concentration, PCV and MCHC were significantly higher among males than females while the platelet count, total WBC count and absolute neutrophil count were significantly higher in females than in males. There was however no significant gender difference in the values of MCV, MCH and absolute lymphocyte count. The normal reference values obtained in this study were notably different from those that are used currently in the hospital. Conclusion: The normal reference value obtained in this study was notable different from those that are currently used in the hospital. These findings will have clinical implications regarding the adjustment of our current reference values and definitely add value to the management of patients in this part of the country.
A comparative time motion study of all types of patient discharges in a hospital

Introduction Discharge is a release of a hospitalized patient from the hospital by the admitting physician after providing necessary medical care for a period deemed necessary. Any hospital needs to work on finer aspects of the discharge process, to make it more patient friendly and less time consuming as it directly connects to patient satisfaction. Methodology This observational study was carried out in a tertiary care 350 bedded hospital in Pune city on 354 discharged patients of all types of discharges, comprising of Insurance patients (104), self-payment patients (227) & discharges against medical advice (DAMA)(23). Results and Discussion The results indicate that there is a delay in all types of discharges in this hospital in all the steps except for the time needed to return unused medicines to the pharmacy. Time and tedious discharge procedure, also contributes to patient dissatisfaction.
The Schedule for the Evaluation of Individual Quality of Life (SEIQoL): The Concept of Quality of Life in Clinical Research

Assessment of quality of life (QoL) is becoming increasingly important in medicine, nursing, and the behavioral and social sciences, particularly as an outcome variable in assessing the impact of disease, illness, and treatment [1-4]. The importance of QoL in medicine and health lies in its encompassing nature: many previously disparate indicators of disease and illness can be incorporated under the umbrella of QoL. In addition, the perspective of the patient is given increased emphasis. Therefore, "quality of life" may be viewed as the expression of a conceptual model intended to represent the perspective of the patient in quantifiable terms. However, despite the increasing popularity of the concept, considerable problems exist in formulation, measurement, and interpretation. There is as yet no agreed-upon definition of exactly what constitutes QoL, nor is there a universally accepted "gold standard" measure. The approach to measurement varies according to the values, aims, and professional training of the investigator.
A Cross-Sectional Exploration of Food Security, Depression, and CHAOS in Low-Income Households with Children

Recommended Citation Pinard, Courtney A. ; Calloway, Eric E. ; Fricke, Hollyanne E. ; and Yaroch, Amy L. (2015) "A Cross-Sectional Exploration of Food Security, Depression, and CHAOS in Low-Income Households with Children," Journal of Applied Research on Children: Informing Policy for Children at Risk: Vol. 6 : Iss. 2 , Article 6. Available at: https://digitalcommons.library. tmc.edu/childrenatrisk/vol6/iss2/6
Hepatotoxicity Associated with the Use of White Flood, a Nutritional Supplement

IntroductIon complementary and alternative medical (CAM) therapies include a variety of herbal and dietary supplements. The use of CAM therapy has been reported by a large percentage of the US population in a variety of survey studies.1-6 The use of herbal and dietary supplements has increased by 50% between 1997-2002.2 These agents are poorly regulated by drug administrations worldwide. The US Congress defined the term “dietary supplement” in the Dietary Supplement Health and Education Act of 1994.7 Under this act, such supplements are categorized as food, rather than drugs. As such, the FDA must show that a supplement is unsafe before action may be taken. This is in contrast to drugs and medications which must be proven safe and effective before they are eligible for marketing. The exact incidence of herbal-induced hepatotoxicity Hepatotoxicity Associated with the Use of White Flood, a Nutritional Supplement
Is transition to disability pension in young people associated with changes in risk of attempted suicide?

Background The aim of the present study was to investigate trajectories of suicide attempt risks before and after granting of disability pension in young people. Method The analytic sample consisted of all persons 16–30 years old and living in Sweden who were granted a disability pension in the years 1995–1997; 2000–2002 as well as 2005–2006 (n = 26 624). Crude risks and adjusted odds ratios for suicide attempt were computed for the 9-year window around the year of disability pension receipt by repeated-measures logistic regressions. Results The risk of suicide attempt was found to increase continuously up to the year preceding the granting of disability pension in young people, after which the risk declined. These trajectories were similar for women and men and for disability pension due to mental and somatic diagnoses. Still, the multivariate odds ratios for suicide attempts for women and for disability pension due to mental disorders were 2.5- and 3.8-fold increased compared with the odds ratios for men and disability pension due to somatic disorders, respectively. Trajectories of suicide attempts differed for young individuals granted a disability pension during 2005–2006 compared with those granted during 1995–1997 and 2000–2002. Conclusions We found an increasing risk of suicide attempt up until the granting of a disability pension in young individuals, after which the risk decreased. It is of clinical importance to monitor suicide attempt risk among young people waiting for the granting of a disability pension.
3-Ethyl-5-(4-methoxyphenoxy)-2-(pyridin-4-yl)-3H-imidazo[4,5-b]pyridine

In the title compound, C20H18N4O2, the imidazopyridine fused ring system is almost perpendicular to the benzene ring [dihedral angle = 87.6 (5)°]. The pyridine ring makes a dihedral angle of 35.5 (5)° with the mean plane of the imidazopyridine fragment. The crystal structure is stabilized by an aromatic π–π stacking interaction between the phenyl rings of neighbouring molecules [centroid–centroid distance = 3.772 (2) Å, interplanar distance = 3.546 (2) Å and slippage = 1.286 (2) Å].
Evaluation and improvement of Germplasm of Aloe Vera L from North India

Supervisor: Prof. M.I. S. Saggoo Submitted by: Ramandeep Kaur There is large scale international trade in the med icinal plants. One such medicinal plant is Aloe vera (L.) Burm. f. (varn. Kuwaargandal, Gheekanwaar ). Aloe vera L. , a member of family Liliaceae is a xerophytic perennial plant with a short, cylin dr cal and simple stem. Aloe vera has been used medicinally for several thousands of years in many cultures. It has a long history dating from Biblica times. Aloe vera is cultivated throughout the world for its thick flesh. Due to vegetative mo de of reproduction, spontaneous cytological and genetical aberration acquired by the plants can get fixed up in their genome. With more than hundred years of Aloe cultivation in India, the possibility of existence of genotypic variability in different clones cannot be ruled out . The present work was undertaken with aim of collection and screening of North Indian Aloe vera germplasm for morphological, cytological, biochemical and genetic variability. I n the light of the results obtained, it is the well-considered opinion of the author that a two wa y approach viz. selection of an improved natural variant for development as cultivar and iso lati n of a high yielding cultivar from the selected genotype though in vitro studies/mutagenesis would be most fruitful for achi eving the twin objectives of conservation of existing gen etic diversity and sustainable utilization of this wonderful gift of GOD.
The Sudden Infant Death Syndrome is a Probability Process

The Sudden Infant Death Syndrome (SIDS) is sudden-unexpected death of an infant that remains unexplained after thorough forensic autopsy, death scene investigation and review of the infant's medical history. As the results of a few spins of a roulette wheel cannot establish whether the wheel is honest (uniform value distribution), medical investigations of a few SIDS cases have not been able to uncover the mechanistic cause of death. We propose that this is because statistical analyses of large numbers of independent observations may be required to unmask the apparent probability processes that govern these quite different phenomena. The SIDS male fraction ~0.60 appears as a binomial probability sample characteristic of a condition caused by an Xlinked gene. The unique SIDS age distribution (minimum at birth, mode ~63 days, median ~94 days, falling exponentially to zero at ~41.2 months) appears as a probability sample from an underlying Johnson SB (4-parameter lognormal) distribution of ages. The presence of this lognormal distribution is prima facie evidence that a probability process is involved. Matching binomial and SB distribution equations to these physiological phenomena, we propose: The SIDS binomial gender distributions arises from an Xlinked recessive allele (q ≈ 2/3) non-protective against acute anoxic encephalopathy; and SIDS Johnson SB age distributions arise from such genetically susceptible infants having Research Article British Journal of Medicine & Medical Research, 3(1): 80-93, 2013 81 three independent risk factors: neurological prematurity (m + 0.31) decreasing with age in months m; risk of respiratory infection increasing with age (41.2 m); and risk of physiological anemia rising and falling with age (2ᴨσ)[exp(-0.5[(y-μ)/σ])] , where y = Log[(m + 0.31)/(41.2 m)] = μ + σ z, μ is median of y, σ is standard deviation of y, with z a standard normal deviate. We show infant Respiratory Distress Syndrome and Suffocation by Inhalation of Food or Foreign Object have approximately the same male fractions as SIDS, supporting the hypothesis that the same allele of an X-linked gene is responsible for death in all these cases.
Disease burden and costs of selected foodborne pathogens in the Netherlands, 2006

Het RIVM heeft voor het eerst de ziektelast en de kosten onderzocht die zes ziekteverwekkende micro-organismen in 2006 veroorzaakten. Het gaat om de toxinevormende bacterien Clostridium perfringens, Staphylococcus aureus en Bacillus cereus, Listeria monocytogenes en het hepatitis A- en E-virus. De bacterien veroorzaken bij mensen darminfecties met diarree en buikgriep als gevolg. Hepatitis leidt tot leverinfecties. Behalve deze infecties is de ziektelast van het prikkelbare darmsyndroom na een voedselinfectie in de berekening opgenomen. Deze ziekte kan onder andere worden opgelopen door een besmetting met de Salmonella bacterie en het norovirus en leidt tot aanhoudende buikklachten. Door deze toevoeging stijgt de totale ziektelast als gevolg van micro-organismen die het prikkelbare darmsyndroom kunnen veroorzaken met veertig procent (een toename met 1400 DALYs per jaar tot bijna 5000). De ziektelast van de toxinevormende bacterien Clostridium perfringens en Staphylococcus aureus zijn tussen de 500 en 700 DALY's per jaar (Disability-Adjusted Life-Years, oftewel het aantal gezonde levensjaren dat een bevolking verliest door ziekte of vroegtijdig overlijden). Deze ziektelast is daarmee vergelijkbaar met infecties als gevolg van de parasiet Giardia en het rotavirus. De ziektelast van Bacillus cereus en het hepatitis A- en E-virus zijn met minder dan 140 DALYs per jaar laag vergeleken met andere voedseloverdraagbare micro-organismen. In het onderzoek zijn zowel de ziekteverwekkers onderzocht als de wijze waarop ze de mens bereiken. Van deze blootstellingroutes is voedsel de belangrijkste bron. Binnen deze categorie blijken kip en rundvlees de belangrijkste bronnen die de micro-organismen overdragen. Het onderzoek is uitgevoerd in opdracht van het ministerie van VWS en helpt om prioriteiten te kunnen aanbrengen in maatregelen die voedselinfecties voorkomen. Het onderzoek is onderdeel van een reeks naar de gezondheidseffecten van ziekteverwekkende micro-organismen waarvan het merendeel via voedsel wordt overgedragen.
Digital Control Of Dynamic Systems 3rd Edition

Eventually, you will completely discover a other experience and attainment by spending more cash. still when? do you give a positive response that you require to acquire those every needs taking into consideration having significantly cash? Why don't you attempt to acquire something basic in the beginning? That's something that will guide you to comprehend even more on the order of the globe, experience, some places, afterward history, amusement, and a lot more?
2-(7-Hydroxy-2-naphthyloxy)-N-(6-methyl-2-pyridyl)acetamide

In the title compound, C18H16N2O3, the dihedral angle between the naphthalene ring system and the pyridyl ring is 18.1 (8)°. The molecules are interconnected via C—H⋯O and O—H⋯O hydrogen bonds. Inversion-related molecules are linked by O—H⋯O hydrogen bonds into cyclic centrosymmetric R 2 2(22) dimers. Intramolecular N—H⋯O hydrogen bonding produces an S(5) ring motif. The crystal structure is further stabilized by weak C—H—π interactions.
(E)-3-(4-Hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

In the title compound, C16H14O4, there is an intramolecular O—H⋯O hydrogen bond. The benzene rings are inclined to one another by 13.89 (9)°. The prop-2-en-1-one group is twisted slightly, the O=C—Car—Car (ar = aromatic) and C=C—C=O torsion angles being −10.4 (3) and −7.4 (3)°, respectively. In the crystal, molecules are linked by O—H⋯O hydrogen bonds, forming chains along [100]. These chains are further linked by O—H⋯O hydrogen bonds, forming corrugated sheets lying parallel to (010). There are C—H⋯π interactions present within the sheets.
Student reflection on physics assessment within an inaugural health foundation year

Teaching physics- and mathematics-based courses to large cohorts of first year health science students, many of whom are not mathematically orientated, presents a significant and unique teaching challenge. This paper summarises successful teaching strategies adopted for one such physics course, while in particular presenting student reflections on assessment methods used within the course. Survey results dispel the effectiveness of traditional heavy examination-weighted modes of first year tertiary physics assessment, and support the need for greater emphasis on educational objectives such as analysis, application and creativity. The approximate ideal weighting of each assessment mode under consideration based on survey results is: end-of-semester examination (40%), mid-semester examination (20%), laboratory reports (20%), assignment (10%), periodic quizzes (8%), and oral presentation (≥2%). This ideal requires appropriate resourcing but is achievable in times of awareness of the role first year success plays in long-term academic success (Pickford, 2007) and increased funding that is available for various student engagement and support strategies.
EFFECT OF APPLYING WARM PERINEAL PACKS DURING THE SECOND STAGE OF LABOR ON PERINEAL PAIN AMONG PRIMIPAROUS WOMEN

Background: Perineal pain experienced during the second stage of labor can have an impact on how a woman views her birth experience and its severity is linked to that of the perineal trauma. The application of perineal warm packs or compresses is widely advocated by midwives to reduce perineal pain and improve comfort during the birth without women having to resort to potentially harmful pharmacological pain relief. Design: This study utilized an experimental research design. Aim: to explore the effect of applying warm perineal packs during the second stage of labor on perineal pains among primiparous women. Setting: The study was conducted at labor & delivery units of Qatif Central Hospital in Al- Qatif (Eastern Province), Kingdom Of Saudi Arabian. Methodology: A total sample of 100 primiparae admitted to previously mentioned setting was comprised the study sample after gaining their acceptance. They were equally divided and randomly assigned to two homogenous groups: Experimental group received warm perineal packs during the second stage of labor and control group received routine hospital care without application of warm perineal packs. Two tools were used for data collection namely: A structured interview questionnaire and Visual Analogue Scale. Results: The pain scores among the experimental group continued to decline significantly (P1& P2, P1&P3 and P2&P3) (P= < 0.001). However, no significant difference was apparent between pain scale measurements (P1&P2= 1.00, P1&P3= 0.3 & P2&P3= 0.3) among the control group. Furthermore, women in the experimental group requested pain relief less frequently than the control group. Conclusion: The application of warm perineal packs had potential benefits on decreasing the level of perineal pain immediately after birth and on day one following birth as well as decreasing the frequency of requiring pain relief.
Ambulatory feedback at daily physical activity patterns: a treatment for the chronic fatigue syndrome in the home environment?

Patients with chronic fatigue syndrome (CFS) are characterized with persistent fatigue which disturbs activities of daily life. The most promising treatment results in CFS are found with cognitive behavioural therapy (CBT) and graded exercise therapy (GET). Both treatment strategies underline the importance of regular physical activity. However, still a significant number of CFS patients do not encounter a reduction of CFS complaints after CBT and GET. The goal of this thesis is to study whether ambulant monitoring of and providing direct feedback on daily physical activities can improve the balance in the daily physical activity pattern and result in improved treatment outcome in patients with CFS. To achieve this goal the daily physical activity pattern is studied in patients with CFS. Subsequently, a ‘state of the art’ feedback system is used to investigate the potential value of ambulant feedback at the daily physical activity pattern in the treatment of CFS. A systematic review (chapter 2) has shown that patients with CFS are less physically active compared to asymptomatic controls. In a subsequent study (chapter 3) it is found that CFS patients have equal physical activity levels in the morning, but decreased levels in afternoon and evening. Ambulant feedback at daily physical activity patterns has shown promising results (chapter 4). Patients with CFS were able to change their daily physical activity pattern into the direction of the goal. Compliance with the feedback system was low and maybe related to the instantaneous effect of the feedback. In a randomized controlled trial no additional value in treatment outcome was found for the ambulant feedback program as supplement to an inpatient rehabilitation program comprising CBT and GET (chapter 5). A second randomized controlled trial has indicated favourable outcome with a more personalized goal pattern in balancing daily physical activity patterns (chapter 6). Ambulant feedback in the home environment of the CFS patient showed promising results in changing the physical activity pattern. It is expected that adequate adaptations in, and implementation of, the ambulant feedback program can contribute to improvements in the treatment of CFS.