Miracle-dz/UniFAR-FTUs huggingface dataset:
FPGA Implementation of RF Based Wearable device of Body Channel Communication (BCC) with RZ Uni-polar Encoding and Decoding using D-QPSK

In the present world, the developments of new ideas and growth of inventions are at very high rate, especially in the case of biomedical applications. It is the need of the hour to find out the root cause of the diseases, to alert the patients and to solve those problems by the medical practitioners. By the usage of human body wearable devices and through the Body Channel Communication (BCC), many diseases for example heart diseases, cancer and blood sugar etc., shall be easily identified and solved. This type of BCC application is helpful for sending and receiving the data vide a long range for the purpose of monitoring patients and giving treatment to them by doctors at the instant point of time during communication. In the existing BCC and associated wearable devices based systems, the human body skin is used as a communication channel for transmitting and receiving the information. In this existing mode of operation, the data transfer speed is very slow, the human freedoms are gets affected, jitter noise is get developed and the data transfer accuracy is low. In order to overcome the above problems, the proposed method is designed with DQPSK modulation using RZ-UNI Polar method. By adopting this technique in wearable devices based BCC, it is possible to realize high data transfer speed even in less bandwidth, high power efficiency and to reduce errors significantly. This proposed work is designed in VHDL Language and it is synthesized using MAX10 Altera Quartus FPGA. The results through the BER Testing and the outputs such as power consumption, chip area and data transfer delay are compared with the previous studies and tabulated.
Knowledge and Perception Regarding Colorectal Cancer Among IIUM Kuantan Undergraduates

Colorectal cancer (CRC) is a cancer of the large intestine with high mortality and morbidity rate. According to the Malaysian National Cancer Registry Report, CRC was reported as the second most frequent cancer after breast cancer. This study was conducted to evaluate the knowledge and perception of IIUM Kuantan Campus students regarding CRC. Currently, there is no national screening program conducted by the Ministry of Health Malaysia for CRC as an early prevention in Malaysia. Despite the increase in incidence and mortality rates of CRC, emphasis on creating awareness regarding CRC among Malaysian is still lacking. Using convenience sampling method and adapted self-administered questionnaires, this cross-sectional study was conducted among the undergraduate students of International Islamic University Malaysia, Kuantan Campus. Overall, more than half of the respondents have a moderate level of knowledge and perceptions regarding CRC. Moreover, there was a significant difference between male and female respondents in terms of knowledge regarding CRC screening (p<0.001). There was also a significant difference in terms of knowledge regarding CRC between different kulliyyahs (p=0.001). However, no correlation was found between knowledge and perception regarding CRC and screening among IIUM Kuantan students. Approximately half of IIUM Kuantan undergraduate students had moderate level of knowledge and perception regarding CRC and screening. Respondents from Kulliyyah of Medicine showed higher knowledge scores compared to respondents from other kulliyyahs, probably due to the educational courses they undertook during their academic years, and to the fact that they were more familiar with the healthcare systems. Female respondents showed higher knowledge score and slightly higher perception score, which could be contributed to females being more concerned in early cancer detection than males. An overall moderate score among the science- and health-based undergraduate students suggested that it is essential to empower the young adults regarding information on colorectal cancer prevention and intention to go for screening. Effective and long-lasting promotional campaigns must be conducted to improve the level of knowledge and perceptions regarding CRC and screening, particularly to benefit the young adults in the community, and this may begin with the undergraduates. Keyword: Knowledge, Perception, Screening, Colorectal cancer, undergraduate student
The evaluation of a live Mycoplasma Gallisepticum vaccine candidate and DNA sequence analysis in the molecular epidemiology of Mycoplasma Gallisepticum

A Mycoplasma gallisepticum (MG) isolate from an atypically mild outbreak in turkey breeders was found to be similar to house finch isolates by DNA analyses. A preliminary study in turkeys showed that this isolate (K5054) caused very mild lesions and protected turkeys against subsequent challenge with a virulent MG strain. The safety and efficacy of K5054 was further evaluated in commercial layer-type chickens and turkeys; there was evidence of protection from lesions associated with MG and reduced isolation of R strain post challenge in vaccinated birds. K5054 was further characterized for stability following in vivo passages through chickens; the persistence and the duration of immunity elicited by a single vaccination; and the transmissibility to unvaccinated chickens. K5054 has shown promise as a safe, efficacious, stable vaccine with relatively low transmissibility and long persistence and duration of immunity. In another study, MG isolates from the USA, Israel and Australia were characterized by random amplified polymorphic DNA (RAPD) analysis as well as DNA sequence analysis of portions of the phase-variable putative adhesin protein (pvpA) gene, the cytadhesin gapA gene and an uncharacterized lipoprotein (LP) sequence. The results were compared to reference strains (vaccine and laboratory strains). The RAPD analysis and combined DNA sequence analysis data correlated well, although sequence analysis of any one of the genes did not result in definitive identification of isolates. The Australian isolates appeared to be more similar to the US isolates than were the Israeli isolates.
Infestation of Honeybee (Apis Mellifera) Colonies by the Parasitic Mites Varroa Jacobsoni and Tropilaelaps Clareae in South Vietnam and Results of Chemical Treatment

SummaryIn honeybee (Apis mellifera) colonies examined in South Vietnam an average of 4·9% of brood cells were infested by Varroa jacobsoni and 46·2% by Tropilaelaps clareae. Average rates of infestation of adult workers were 6·3 per 100 for V. jacobsoni and 3·4 per 100 for T. clareae. Thus, despite a tenfold higher infestation of brood by T. clareae, infestation of adults by V. jacobsoni was twice as high. Amitraz was more effective than phenotiazine against both mite species, killing 95·7% of V. jacobsoni and 79·2% of T. clareae mites whereas phenotiazine killed only 57·7% of V. jacobsoni mites and 56·4% of T. clareae. Because of the low incidence of V. jacobsoni, mite treatment in Vietnam should be concentrated on T. clareae which can be controlled without medication.
The Potential Therapeutic Role of Proton Pump Inhibitors in COVID-19: Hypotheses Based on Existing Evidences

Abstract Although the major therapeutic uses of the proton pump inhibitors are in gastric-acid related diseases, evidences are suggestive of a pleiotropic nature of the compounds. We comment on the probable pathways and cellular machineries via which proton pump inhibitors could show beneficial therapeutic effects against SARS-CoV-2 based on the existing evidences. Proton pump inhibitors have shown antiviral potencies in various in vivo and in vitro studies. Some of the major possible ways through which they can act against SARS-CoV-2 are by exerting anti-inflammatory and anti-fibrotic effects, via vacuolar ATPase pumps leading to raised endolysosomal pH and by targeting endosomal complexes. The current pandemic has put forward a challenge to find treatment options. Although the potential roles of proton pump inhibitors against SARS-CoV-2 have been discussed in recent publications, the clinical evidences for their real-world effectiveness do not point towards a beneficial effect clearly yet. We suggest that although proton pump inhibitors should strongly be considered as potential therapeutic options for COVID-19, larger studies in the form of randomized controlled trials would be required to arrive at a definite conclusion.
Phylogeny of butterflies of the subfamily Elymninae and Satyrinae (Lepidoptera:Satyridae) based on mitochondrial COI and Cytb gene sequences

In order to clarify the unresolved phylogentic relationships of some lineages of the family Satyridae,the fragments of the mitochondrial COⅠ and Cytb genes of 21 Chinese species of the subfamily Elymninae and Satyrinae(Satyridae)were newly amplified and sequenced;meanwhile,the homologous sequences of two foreign species were obtained from the GenBank.Based on these data,the sequence variation and the phylogenetic relationship of these groups were analyzed.The results of the sequence analysis showed that the two combined genes is 1 056 bp in length by alignment,including 648 conserved,408 variable and 316 parsimonious-informative sites;the average percentage of A+T is 70.8%,which is much higher than that of C+G(29.2%). Using two nymphalid species as the outgroups,their phylogenetic trees were reconstructed with neighbor-joining(NJ),maximum-parsimony(MP)and bayesian inference(BI)methods.The results indicated that the subfamilies Satyrinae,Elymninae and the tribe Lethini all are not monophyletic;the tribes Mycalesini and Lethini should be moved from the subfamily Elymninae to the subfamily Satyrinae;the tribes Satyrini,Melanargiini and Maniolini might have a closest common ancestor;and additionally,the tribes Palaeonymphini,Mycalesini and Ypthimini are also closely related to one another.
Compound warm–dry and cold–wet events over the Mediterranean

Abstract. The Mediterranean (MED) Basin is a climate change hotspot that has seen drying and a pronounced increase in heatwaves over the last century. At the same time, it is experiencing increased heavy precipitation during wintertime cold spells. Understanding and quantifying the risks from compound events over the MED is paramount for present and future disaster risk reduction measures. Here, we apply a novel method to study compound events based on dynamical systems theory and analyse compound temperature and precipitation events over the MED from 1979 to 2018. The dynamical systems analysis quantifies the strength of the coupling between different atmospheric variables over the MED. Further, we consider compound warm–dry anomalies in summer and cold–wet anomalies in winter. Our results show that these warm–dry and cold–wet compound days are associated with large values of the temperature–precipitation coupling parameter of the dynamical systems analysis. This indicates that there is a strong interaction between temperature and precipitation during compound events. In winter, we find no significant trend in the coupling between temperature and precipitation. However in summer, we find a significant upward trend which is likely driven by a stronger coupling during warm and dry days. Thermodynamic processes associated with long-term MED warming can best explain the trend, which intensifies compound warm–dry events.
Bionanocomposite Films Containing Halloysite Nanotubes and Natural Antioxidants with Enhanced Performance and Durability as Promising Materials for Cultural Heritage Protection

In the last decade, the interest toward the formulation of polymer films for cultural heritage protection continuously grew, and these films must be imperatively transparent, removable, and should not react/interact with surface of the artworks. In this research, bionanocomposite films, based on chitosan (Ch) and pectin (P) and containing naturally occurring fillers and antioxidants, were formulated by solvent casting methods and were accurately characterized. The natural halloysite nanotubes (HNT) have a two-fold role, specifically, physical compatibilizer and antioxidant carrier. Therefore, the theoretical solubility between Ch and P was estimated considering Hoy’s method for solubility of polymers, while the optimum ratio between biopolymer constituents was assessed by ζ-potential measurements. The transparency, wettability, and mechanical behavior of Ch:P films, also in presence of HNT without and with antioxidants, were investigated. The beneficial effects of natural antioxidants, such as vanillic acid (VA) and quercetin (Q), on Ch:P/HNT durability were found.
Use of Antibiotics in Endodontics-Clinical Practice Guidelines

Endodontic infection is complex owing to its polymicrobial nature, consisting of gram positive, gram negative, and facultative anaerobes. Therefore, the causative microorganism cannot be definitely identified, and most commonly broad spectrum antibiotics are prescribed on a presumptive basis. Irrational and overuse of antibiotics results in the emergence of antibiotic resistance and also increases the risks of hypersensitivity reactions, like anaphylaxis. The purpose of this guidelines is to concise and provide an evidence based knowledge on antibiotic prescription and their usage in endodontic.
Expression Profiling of Extracellular Matrix Genes Reveals Global and Entity-Specific Characteristics in Adenoid Cystic, Mucoepidermoid and Salivary Duct Carcinomas

Simple Summary The extracellular matrix (ECM), an important factor in tumour metastasis and therapy resistance, has not been studied in salivary gland carcinomas (SGC), so far. In this retrospective study, we profiled the RNA expression of 28 ECM-related genes in 11 adenoid cystic (AdCy), 14 mucoepidermoid (MuEp) and 9 salivary duct carcinomas (SaDu). Also, we validated our results in a multimodal approach. MuEp and SaDu shared a common gene signature involving an overexpression of COL11A1. In contrast, nonhierarchical clustering revealed a more specific gene expression pattern for AdCy, characterized by overexpression of COL27A1. In situ studies at RNA level indicated that in AdCy, ECM production results from tumour cells and not from cancer-associated fibroblasts as is the case in MuEp and SaDu. For the first time, we characterized the ECM composition in SGC and identified several differentially expressed genes, which are potential therapeutic targets. Abstract The composition of the extracellular matrix (ECM) plays a pivotal role in tumour initiation, metastasis and therapy resistance. Until now, the ECM composition of salivary gland carcinomas (SGC) has not been studied. We quantitatively analysed the mRNA of 28 ECM-related genes of 34 adenoid cystic (AdCy; n = 11), mucoepidermoid (MuEp; n = 14) and salivary duct carcinomas (SaDu; n = 9). An incremental overexpression of six collagens (including COL11A1) and four glycoproteins from MuEp and SaDu suggested a common ECM alteration. Conversely, AdCy and MuEp displayed a distinct overexpression of COL27A1 and LAMB3, respectively. Nonhierarchical clustering and principal component analysis revealed a more specific pattern for AdCy with low expression of the common gene signature. In situ studies at the RNA and protein level confirmed these results and indicated that, in contrast to MuEp and SaDu, ECM production in AdCy results from tumour cells and not from cancer-associated fibroblasts (CAFs). Our findings reveal different modes of ECM production leading to common and distinct RNA signatures in SGC. Of note, an overexpression of COL27A1, as in AdCy, has not been linked to any other neoplasm so far. Here, we contribute to the dissection of the ECM composition in SGC and identified a panel of deferentially expressed genes, which could be putative targets for SGC therapy and overcoming therapeutic resistance.
Seasonal Evolution of Size-Segregated Particulate Mercury in the Atmospheric Aerosol Over Terra Nova Bay, Antarctica

Size-fractionated particulate mercury (PHg) measurements were performed from November 2017 to January 2018 at Terra Nova Bay (Antarctica) for the first time. Samples were collected every 10 days by a six-stage high-volume cascade impactor with size classes between 10 μm and 0.49 μm. Total PHg concentrations were maxima (87 ± 8 pg m−3) in November, then decreased to values ~40% lower and remained almost constant until the end of the sampling period (~30 pg m−3). The trimodal aerosol mass distribution reveals that from 30% to 90% of the total PHg came in the size > 1.0 μm. Hg in the two coarse fractions was probably produced by the adsorption of oxidized Hg species transported by air masses from the Antarctic plateau or produced locally by sea ice edges. PHg in accumulation mode seemed to be related to gas–particle partitioning with sea salt aerosol. Finally, average dry deposition fluxes of PHg were calculated to be 0.36 ± 0.21 ng m−2 d−1 in the accumulation mode, 47 ± 44 ng m−2 d−1 in the first coarse mode, and 37 ± 31 ng m−2 d−1 in the second coarse mode. The present work contributed to the comprehension of the Hg biogeochemical cycle, but further research studies are needed.
New Strategy for Improving the Accuracy of Aircraft Positioning Based on GPS SPP Solution

The paper describes and presents a new calculation strategy for the determination of the aircraft’s resultant position using the GPS (Global Positioning System) SPP (Single Point Positioning) code method. The paper developed a concept of using the weighted average model with the use of measuring weights to improve the quality of determination of the coordinates and accuracy of GPS SPP positioning. In this research, measurement weights were used as a function of the number of GPS satellites being tracked, and geometric PDOP (Position Dilution of Precision) coefficient. The calculations were made using navigation data recorded by two independent GPS receivers: Thales Mobile Mapper and Topcon HiPerPro. On the basis of the obtained results, it was found that the RMS (Root Mean Square) accuracy of positioning for XYZ geocentric coordinates was better than 1.2% to 33.7% for the weighted average method compared to a single GPS SPP solution. The proposed approach is therefore of practical application in air navigation to improve the quality of aircraft positioning.
The Araceae of Borneo-The Genera

A summary of the aroids of Borneo of the rank of genus and above is offered. 36 genera are listed, of which 35 are indigenous, and one (Typhonium Schott) genuinely naturalized. Of the 35 indigenous genera, eight (Aridarnm Ridl., Bakoa P.C.Boyce & S.Y.Wong, Bucephalandra Schott, Ooia S.Y.Wong & P.C.Boyce, Pedicellarnm M.Hotta, Phymatarnm M.Hotta, Pichinia S.Y.Wong & P.C.Boyce, and Schottariella P.C.Boyce & S.Y.Wong) are Bornean endemics. Four additional genera (Caladium Vent., Dieffenbachia Schott, Syngonium Schott, and Xanthosoma Schott) are listed as adventives. The aroid flora of Borneo currently stands at 670 indigenous species, of which more than 40% are undescribed novelties, and with this figure based significantly on our understanding of the flora of Sarawak, Sabah and Brunei (Le. less than one third of the total landmass). Kalimantan, comprising more than 70% of the land area of Borneo remains very poorly known, and undoubtedly harbors a great many novel species. It is estimated that the total aroid flora for Borneo quite likely exceeds 1,000 species, with barely one third of these described. Borneo is an aroid habitat of global significance, and arguably one of the richest and diverse on the planet. World and Bornean taxonomy and ecology are briefly outlined, along with a summary of the history of aroid fieldwork in Borneo. The most recent key literature is cited, and keys to Bornean aroid taxa of genus and above are presented. Most genera are illustrated.
Adding Haptic Feedback to Virtual Environments With a Cable-Driven Robot Improves Upper Limb Spatio-Temporal Parameters During a Manual Handling Task

Physical interactions within virtual environments are often limited to visual information within a restricted workspace. A new system exploiting a cable-driven parallel robot to combine visual and haptic information related to environmental physical constraints (e.g. shelving, object weight) was developed. The aim of this study was to evaluate the impact on user movement patterns of adding haptic feedback in a virtual environment with this robot. Twelve healthy participants executed a manual handling task under three conditions: 1) in a virtual environment with haptic feedback; 2) in a virtual environment without haptic feedback; 3) in a real physical environment. Temporal parameters (movement time, peak velocity, movement smoothness, time to maximum flexion, time to peak wrist velocity) and spatial parameters of movement (maximum trunk flexion, range of motion of the trunk, length of the trajectory, index of curvature and maximum clearance from the shelf) were analysed during the reaching, lowering and lifting phases. Our results suggest that adding haptic feedback improves spatial parameters of movement to better respect the environmental constraints. However, the visual information presented in the virtual environment through the head mounted display appears to have an impact on temporal parameters of movement leading to greater movement time. Taken together, our results suggest that a cable-driven robot can be a promising device to provide a more ecological context during complex tasks in virtual reality.
The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution

Photoreceptor cells in the eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular components and physiology. First data on the recently discovered xenopsin point towards a more complex situation in protostomes. In this study, we provide clear evidence that xenopsin enters cilia in the eye of the larval bryozoan Tricellaria inopinata and triggers phototaxis. As reported from a mollusc, we find xenopsin coexpressed with rhabdomeric-opsin in eye photoreceptor cells bearing both microvilli and cilia in larva of the annelid Malacoceros fuliginosus. This is the first organism known to have both xenopsin and ciliary opsin, showing that these opsins are not necessarily mutually exclusive. Compiling existing data, we propose that xenopsin may play an important role in many protostome eyes and provides new insights into the function, evolution, and possible plasticity of animal eye photoreceptor cells.
Rescue of chemorefractory classical Hodgkin lymphoma with nivolumab and autologous stem‐cell transplantation: Real‐life experience

Nivolumab is approved for relapsed/refractory Classical Hodgkin Lymphoma (r/rCHL). Whether nivolumab may be used as a bridge to autologous stem cell transplantation (ASCT) is not accurately investigate. We report a series of five cases of CHL chemorefractory to several lines of salvage therapy treated with nivolumab monotherapy and ASCT. Following ASCT, four patients achieved complete response (CR) and one remained with indeterminate FDG-avid lesions by PET/CT. All patients are in CR at last follow-up with a median duration of response of 36.4 months. No patient has received post-ASCT treatment. ASCT in chemorefractory CHL responding to nivolumab therapy may yield sustainable remission in this high-risk population. This article is protected by copyright. All rights reserved.