Miracle-dz/UniFAR-FTUs huggingface dataset:
Family sociodemographic resources moderate the path from toddlers’ hard-to-manage temperament to parental control to disruptive behavior in middle childhood

Abstract Research inspired by ecological perspectives has amply documented broad effects of the family's sociodemographic resources on children's outcomes, with parents’ young age, low education, and low income considered risk factors. Typically, sociodemographic characteristics have been studied as influencing child outcomes either directly or indirectly through parenting. We tested a more nuanced longitudinal model in a community sample of 102 infants, mothers, and fathers. We conceptualized family sociodemographic resources, measured as a composite of parents’ ages, education, and income, as moderating developmental cascades from children's hard-to-manage temperament to parental power-assertive control to children's disruptive behavior problems. Children's temperament measures encompassed proneness to anger and inability to delay, observed at 2 and 3 years in standard laboratory episodes. We observed parents’ control at 4.5 and 5.5 years in lengthy naturalistic prohibition paradigms, and obtained parental ratings of children's disruptive behavior at 6.5 and 8 years. As expected, moderated mediation analyses, covarying stability of children's difficulty and parental control, revealed that the cascade from hard-to-manage temperament to child behavior problems, mediated by parental power-assertive control, was present in families with relatively more disadvantaged sociodemographic characteristics, or fewer resources, but absent in families with more advantageous sociodemographic features, or more resources. The findings were parallel for mother– and father–child dyads.
Self-monitoring diabetes with multiple mobile health devices

OBJECTIVE The purpose of this study was to examine the use of multiple mobile health technologies to generate and transmit data from diverse patients with type 2 diabetes mellitus (T2DM) in between clinic visits. We examined the data to identify patterns that describe characteristics of patients for clinical insights. METHODS We enrolled 60 adults with T2DM from a US healthcare system to participate in a 6-month longitudinal feasibility trial. Patient weight, physical activity, and blood glucose were self-monitored via devices provided at baseline. Patients also responded to biweekly medication adherence text message surveys. Data were aggregated in near real-time. Measures of feasibility assessing total engagement in device submissions and survey completion over the 6 months of observation were calculated. RESULTS It was feasible for participants from different socioeconomic, educational, and racial backgrounds to use and track relevant diabetes-related data from multiple mobile health devices for at least 6 months. Both the transmission and engagement of the data revealed notable patterns and varied by patient characteristics. DISCUSSION Using multiple mobile health tools allowed us to derive clinical insights from diverse patients with diabetes. The ubiquitous adoption of smartphones across racial, educational, and socioeconomic populations and the integration of data from mobile health devices into electronic health records present an opportunity to develop new models of care delivery for patients with T2DM that may promote equity as well.
Religious Identity Dissonance: Understanding How Sexual Minority Adolescents Manage Antihomosexual Religious Messages

ABSTRACT Sexual minority adolescents from religious contexts may be at high risk of mental health issues due to religious identity dissonance. This study investigated the cognitive strategies used to manage antihomosexual religious messages and resolve religious identity dissonance among sexual minority adolescents. In 2014, 46 adolescents were interviewed in Los Angeles, CA. Youths were prompted to discuss experiences with religion, antihomosexual messages, and their strategies for managing these messages. Ninety-one percent of the sample reported hearing antihomosexual religious messages. Messages came from multiple sources (e.g., parents, pastors) and contained three types of content (i.e., creation, sin, and afterlife). A quarter of the sample reported religious identity dissonance. Three primary strategies to manage antihomosexual messages emerged. Findings indicate that all youths, including nonreligious youths, use cognitive strategies to manage negative messages and that these strategies relate to current religious identification.
Stakeholder Perceptions of Internet-Delivered Cognitive Behavior Therapy as a Treatment Option for Alcohol Misuse: Qualitative Analysis

Background Internet-delivered cognitive behavior therapy (ICBT) has been found to be effective for treating alcohol misuse in research trials, but it is not available as part of routine care in Canada. Recent recommendations in the literature highlight the importance of integrating perspectives from both patient and health care stakeholders when ICBT is being implemented in routine practice settings. Objective This study aimed to gain an understanding of how ICBT is perceived as a treatment option for alcohol misuse by interviewing diverse stakeholders. Specifically, the objectives were to (1) learn about the perceived advantages and disadvantages of ICBT for alcohol misuse and (2) elicit recommendations to inform implementation efforts in routine practice. Methods A total of 30 participants representing six stakeholder groups (ie, patients, family members, academic experts, frontline managers, service providers, and health care decision makers) participated in semistructured interviews. To be included in the study, stakeholders had to reside in Saskatchewan, Canada, and have personal or professional experience with alcohol misuse. Interviews were transcribed verbatim, anonymized, and analyzed using thematic analysis. Results Stakeholders identified numerous advantages of ICBT for alcohol misuse (eg, accessibility, convenience, privacy, relevance to technology-based culture, and fit with stepped care) and several disadvantages (eg, lack of internet access and technological literacy, isolation, less accountability, and unfamiliarity with ICBT). Stakeholders also provided valuable insight into factors to consider when implementing ICBT for alcohol misuse in routine practice. In terms of intervention design, stakeholders recommended a 6- to 8-week guided program that uses Web-based advertising, point-of-sale marketing, and large-scale captive audiences to recruit participants. With regard to treatment content, stakeholders recommended that the program focus on harm reduction rather than abstinence; be evidence based; appeal to the diverse residents of Saskatchewan; and use language that is simple, encouraging, and nonjudgmental. Finally, in terms of population characteristics, stakeholders felt that several features of the alcohol misuse population, such as psychiatric comorbidity, readiness for change, and stigma, should be considered when developing an ICBT program for alcohol misuse. Conclusions Stakeholders’ insights will help maximize the acceptability, appropriateness, and adoption of ICBT for alcohol misuse and in turn contribute to implementation success. The methodology and findings from this study could be of benefit to others who are seeking to implement ICBT in routine practice.
Tuberculosis series 2020

1. Faculdade de Medicina, Universidade Federal do Rio Grande do Sul – UFRGS – Porto Alegre (RS) Brasil. 2. Instituto de Doenças do Tórax – IDT – Faculdade de Medicina, Universidade Federal do Rio de Janeiro – UFRJ – Rio de Janeiro (RJ) Brasil. 3. Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri – IRCCS – Tradate, Italia. 4. Blizard Institute, Queen Mary University of London, London, United Kingdom. According to the World Health Organization (WHO), tuberculosis is the leading cause of death from a single infectious agent worldwide,(1) as well as being the leading cause of death among people living with HIV. In 2018, there were an estimated 10 million new tuberculosis cases worldwide, and 1.5 million people died from the disease. In the same year in Brazil, the incidence of tuberculosis was 45 cases/100,000 population, and the tuberculosis-related mortality rate was 2.3 deaths/100,000 population. (1) Therefore, in celebration of World TB Day, on March 24th, this issue of the JBP features several articles focusing on diverse aspects of tuberculosis control.
A Case of Right Temporal Lobectomy for Brain Tumor With Selective Semantic Pictorial Disorder

Disagreement exists regarding representational and connectionist interpretations of semantic knowledge subserved by the right versus left anterior temporal lobes (ATLs). These interpretations predict a different pattern of impairment in patients with a right unilateral ATL lesion. We conducted a neuropsychological study of a selective semantic pictorial defect exhibited by a 57-year-old man who had undergone a right temporal lobectomy due to the presence of a glioblastoma. The patient was given the Thematic and Taxonomic Semantic task, in which individuals must select, within triplets of words or pictures, the best associates of living or nonliving stimuli, related by thematic or taxonomic links, and presented in the verbal or pictorial modality. The selectivity of the defect was documented by a comparison between the results obtained by our patient and those obtained by healthy controls on living items and on pictures with a thematic relation. The selectivity of the defect was confirmed by a within-subject analysis of the results obtained on all of the task’s triplets and those obtained on the stimuli representing living entities with a taxonomic relation. The selectivity of this semantic pictorial defect mainly concerning living entities is consistent with the representational account of semantic defects observed in our patient. In the present case report, a right temporal lobectomy resulted in a selective semantic pictorial defect with the qualitative features predicted by the representational account of semantic defects observed after a unilateral ATL lesion.
Delineation of musculocontractural Ehlers–Danlos Syndrome caused by dermatan sulfate epimerase deficiency

Musculocontractural Ehlers–Danlos Syndrome (mcEDS) is a rare connective tissue disorder caused by biallelic loss‐of‐function variants in CHST14 (mcEDS‐CHST14) or DSE (mcEDS‐DSE), both of which result in defective dermatan sulfate biosynthesis. Forty‐one patients with mcEDS‐CHST14 and three patients with mcEDS‐DSE have been described in the literature.
Preconception Hb concentration with risk of spontaneous abortion: a population-based cohort study in over 3·9 million women across rural China

Abstract Objective: Evidence on the relationship between maternal Hb concentration and spontaneous abortion (SA) risk is limited and conflicting. The purpose of the study was to evaluate whether maternal preconception anaemia or high Hb concentration is associated with risk of SA. Design: A population-based cohort study established between 2013 and 2017. Settings: Local maternal and child care service centres in each county. Participants: In total, 3 971 428 women aged 20–49 years, who participated in National Free Pre-Pregnancy Checkups Project from 2013 to 2016 and successfully got pregnant before 2017 in rural China. Results: A total of 101 700 (2·56 %) women were recorded having SA, with highest SA rate in women with severe anaemia (4·58 %). Compared with women with Hb of 110–149 g/l, the multivariable-adjusted OR for SA was 1·52 (95 % CI: 1·25, 1·86) for women with Hb < 70 g/l, 0·92 (0·84, 1·01) for 70–99 g/l, 0·80 (0·77, 0·83) for 100–109 g/l, 1·11 (1·08, 1·15) for 150–159 g/l, 1·12 (1·04, 1·20) for 160–169 g/l and 1·02 (0·93, 1·12) for ≥ 170 g/l, respectively. An approximate U-shaped curve for the risk of SA with Hb concentrations was observed when Hb concentrations less than 145 g/l, above which the association plateaued (P non-linear < 0·001). Conclusions: Severe anaemia and high Hb concentration before pregnancy were associated with an increased risk of SA. Women with mild anaemia prior to pregnancy had lower risk of SA. Underlying mechanisms need to be further studied.
Urine as a biological modality for colorectal cancer detection

ABSTRACT Introduction: The increasing incidence of colorectal cancer (CRC) in young adults warrants early and preferably noninvasive diagnostic modalities. Although the current stool-based assays have had good performance indicators for CRC detection, the overall poor uptake remains a challenging issue. However, alternative blood and urine markers are emerging. Areas covered: This paper discusses the various urinary biomarkers available for the detection of CRC. The more commonly encountered drawbacks are the small number of studies and the size of the study population. We discuss the role of microRNA and ProstaglandinE2 in CRC detection. The emergence of new, low-cost technologies, specifically in the detection of volatile organic compounds (VOCs), presents a promising future. We postulate possible mechanisms for the origin of these VOCs in urine and their role in carcinogenesis. Expert opinion: Urinary biomarkers provide an alternative option to the stool-based screening tests. MicroRNA and ProstaglandinE2 have shown utility in CRC detection. Evidence so far suggests that VOCs could also be a potential biomarker for the detection of CRC. In addition to its interaction within the colon lumen, this altered ‘VOC signature’ might also play a role in carcinogenesis. Low-cost technology may enable such diagnostic methods to be utilized at the point of care.
Non-invasive prenatal testing for aneuploidy, copy number variants and single gene disorders.

The discovery of cell-free fetal DNA (cffDNA) in maternal plasma has enabled a paradigm shift in prenatal testing, allowing for safer, earlier detection of genetic conditions of the fetus. Non-invasive prenatal testing (NIPT) for fetal aneuploidies has provided an alternative, highly efficient approach to first-trimester aneuploidy screening, and since its inception has been rapidly adopted worldwide. Due to the genome-wide nature of some NIPT protocols, the commercial sector has widened the scope of cell-free DNA (cfDNA) screening to include sex chromosome aneuploidies, rare autosomal trisomies and sub-microscopic copy number variants. These developments may be marketed as "expanded NIPT" or "NIPT Plus", and bring with them a plethora of ethical and practical considerations. Concurrently, cfDNA tests for single gene disorders, termed non-invasive prenatal diagnosis (NIPD), have been developed for an increasing array of conditions but are less widely available. Despite the fact that all these tests utilise the same biomarker, cfDNA, there is considerable variation in key parameters such as sensitivity, specificity and positive predictive value depending on what the test is for. The distinction between diagnostics and screening has become blurred, and there is a clear need for the education of physicians and patients regarding the technical capabilities and limitations of these different forms of testing. Furthermore, there is a requirement for consistent guidelines that apply across health sectors, both public and commercial, to ensure that tests are validated and robust, and that careful and appropriate pre-test and post-test counselling is provided by professionals who understand the tests offered.
Can dietary self-reports usefully complement blood concentrations for estimation of micronutrient intake and chronic disease associations?

BACKGROUND We recently presented associations between serum-based biomarkers of carotenoid and tocopherol intake and chronic disease risk in a Women's Health Initiative (WHI) Measurement Precision subcohort (n = 5488). Questions remain as to whether self-reported dietary data can usefully augment such biomarkers or can be calibrated using biomarkers for reliable disease association estimation in larger WHI cohorts. OBJECTIVES The aims were to examine the potential of FFQ data to explain intake variation in a WHI Feeding Study and to compare association parameter estimates and their precision from studies based on biomarker-calibrated FFQ intake in larger WHI cohorts, with those previously presented. METHODS Serum-based intake measures were augmented by using FFQ data in a WHI Feeding Study (n = 153). Corresponding calibration equations were generated, both in a companion Nutritional Biomarker Study (n = 436) and in the previously mentioned subcohort (n = 5488), by regressing these intake measures on dietary data and participant characteristics, for α- and β-carotene, lutein plus zeaxanthin, and α-tocopherol. The supplemental value of FFQ data was considered by examining the fraction of feeding study intake variation explained by these regression models. Calibrated intake and disease association analyses were evaluated by comparisons with previously reported subcohort results. RESULTS The inclusion of FFQ data led to some increases in feeding study intake variation explained (total R2 of ∼50%). Calibrated intake estimates explained 25-75% of serum-based intake variation, whether developed using either of the 2 cohort subsamples. Related disease associations for micronutrients were precisely estimated in larger WHI cohorts (n = 76,691) but were often closer to the null compared with previously reported associations. CONCLUSIONS FFQ data may usefully augment blood concentrations in estimating the intake of carotenoids and tocopherols. Calibrated intake estimates using FFQ, dietary supplement, and participant characteristics only may require further justification to ensure reliable estimation of related disease associations.
Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination

Non-thermal plasma (NTP) has been studied as a novel therapeutic tool for cancer that does not damage healthy cells. In this study, we show that NTP-treated solutions (NTS) can induce death in various leukemia cells through mechanistic target of rapamycin (mTOR) ubiquitination. Previously, we manufactured and demonstrated the efficacy of NTS in solid cancers. NTS did not exhibit any deleterious side effects, such as acute death or weight loss in nude mice. In the present study, NTS induced cell death in myeloid leukemia cells, including acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). We found that mTOR was downregulated in NTS-treated cells via the ubiquitin-proteasome system (UPS). We also identified ‘really interesting new gene’ finger protein 126 (RNF126) as a novel binding protein for mTOR through protein arrays and determined the role of E3 ligase in NTS-induced mTOR ubiquitination. NTS-derived reactive oxygen species (ROS) affected RNF126 expression and lysosomal dysfunction. These findings suggest that NTS has potential antileukemic effects through RNF126-mediated mTOR ubiquitination with no deleterious side effects. Thus, NTS may represent a new therapeutic method for chemotherapy-resistant leukemia.
Development and field validation of an omni-domain power-duration model

ABSTRACT Purpose: To validate and compare a novel model based on the critical power (CP) concept that describes the entire domain of maximal mean power (MMP) data from cyclists. Methods: An omni-domain power-duration (OmPD) model was derived whereby the rate of Wʹ expenditure is bound by maximum sprint power and the power at prolonged durations declines from CP log-linearly. The three-parameter CP (3CP) and exponential (Exp) models were likewise extended with the log-linear decay function (Om3CP and OmExp). Each model bounds Wʹ using a different nonconstant function, Wʹeff (effective Wʹ). Models were fit to MMP data from nine cyclists who also completed four time-trials (TTs). Results: The OmPD and Om3CP residuals (4 ± 1%) were smaller than the OmExp residuals (6 ± 2%; P < 0.001). Wʹeff predicted by the OmPD model was stable between 120–1,800 s, whereas it varied for the Om3CP and OmExp models. TT prediction errors were not different between models (7 ± 5%, 8 ± 5%, 7 ± 6%; P = 0.914). Conclusion: The OmPD offers similar or superior goodness-of-fit and better theoretical properties compared to the other models, such that it best extends the CP concept to short-sprint and prolonged-endurance performance.
Antiemetics in Children With Acute Gastroenteritis: A Meta-analysis

In this systematic review and NMA, we summarize the evidence supporting the use of ondansetron for achieving cessation of vomiting and reducing hospitalizations. CONTEXT: Several antiemetics have been used in children with acute gastroenteritis. However, there is still controversy over their use. OBJECTIVE: To determine the effectiveness and safety of antiemetics for controlling vomiting in children with acute gastroenteritis. DATA SOURCES: Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, Latin America and the Caribbean Literature on Health Sciences, and gray literature, until December 2018. STUDY SELECTION: We selected randomized clinical trials comparing metoclopramide, ondansetron, domperidone, dexamethasone, dimenhydrinate, and granisetron. DATA EXTRACTION: Two reviewers independently screened abstracts and full texts, extracted the data, and assessed the risk of bias. We performed pairwise and network meta-analysis using the random-effects model. RESULTS: Twenty-four studies were included (3482 children). Ondansetron revealed the largest effect in comparison to placebo for cessation of vomiting (odds ratio = 0.28 [95% credible interval = 0.16 to 0.46]; quality of evidence: high) and for hospitalization (odds ratio = 2.93 [95% credible interval = 1.69 to 6.18]; quality of evidence: moderate). Ondansetron was the only intervention that reduced the need for intravenous rehydration and the number of vomiting episodes. When considering side effects, dimenhydrinate was the only intervention that was worse than placebo. LIMITATIONS: Most treatment comparisons had low- or very low–quality evidence, because of risk of biases and imprecise estimates. CONCLUSIONS: Ondansetron is the only intervention that revealed an effect on the cessation of vomiting, on preventing hospitalizations, and in reducing the need for intravenous rehydration. Ondansetron was also considered a safe intervention.