Miracle-dz/UniFAR-FTUs huggingface dataset:
Urinary Paraben Concentrations and Its Association with Serum Triglyceride Concentrations in 2013–2014 NHANES Participants (P08-120-19)

Alkyl esters of para-hydroxybenzoic acid, colloquially known as parabens, are types of preservatives found in multiple foodstuffs, pharmaceuticals and personal care products to which Americans are exposed daily. It is unclear if parabens exhibit carcinogenic or endocrine-disrupting properties. Methylparaben and propylparaben, two of the parabens most commonly found in foods, may interact with triglycerides in adipose tissue and impact lipid metabolism. Due to the potential for adverse impact, it is imperative to study how parabens interact with lipids in humans. Our objective was to evaluate the association between urinary parabens and serum triglyceride concentrations. This cross-sectional study used data from adults 20 years and older from the 2013–2014 NHANES. Triglyceride levels were associated with urinary paraben concentrations (methyl and propyl) using a Hierarchical Multiple Regression, adjusting for ethnicity/race, gender, waist circumference, BMI and age. A total of 794 participants were included in the analyses; their mean age was 49.7 years, 52.4% were female, 43.07% were white, and 20.2% were black. Triglycerides were inversely associated with methylparaben (CI 95% −.054, −.004, β = -0.82, P = 0.022) and propylparaben (CI 95% −.04, −.003, β = -0.81, P = 0.026). When adjusting for age, gender, race/ethnicity, BMI and waist circumference, the model remained significant for methylparaben (P < 0.05, adjusted R2 = .140), and propylparaben (P < 0.05, adjusted R2 = .140). Despite the potential detrimental effects of parabens on triglycerides, our results suggest that urinary excretion of methylparaben and propylparaben are associated with lower circulating triglycerides. Further research is needed to confirm the mechanisms and health impact of this relationship. Florida International University Internal Funding.
Role of autologous platelet-rich plasma (PRP) eye drops as monotherapy for the treatment of severe dry eye disease

Objective: To evaluate use of autologous platelet-rich plasma (PRP) eye drops for the treatment of severe dry eye disease. Materials & Method: This is a retrospective study conducted at a tertiary eye care centre. 30 patients with severe dry eye disease (DED) were included in this study. Data obtained from medical records of patients. Following information noted from medical records. Type of dry eye as evaporative DED (EDED) or aqueous deficient DED (ADDED). Following information were noted before treatment with PRP eye drops and on each follow up visits; OSDI score(Subjective symptoms), Corneal Fluorescein Staining (CFS), Tear Film Breakup Time (TBUT) , Tear Meniscus Height (TMH) and Schirmer’s score (SCH 1). Follow up done at 1 week, 1 month, 3 month and final follw up done at 6 months. Results: Out of 30 cases 19 (63.3 %) were women, and 11 (36.6 %) were men.16 (53.3 %) had EDED, while 14 (46.6%) had ADDED. 6 months of monotherapy with autologous PRP resulted reduction in dry eye symptoms in 28 (93.3 %) cases. CFS decreased in 23 (76.6 %) patients, TBUT improved in 26 (86.6%) patients, tear meniscus height improved in 24 (80.0%) patients and schirmers score improved in 16 (53.3 %) patients. Conclusion: Autologous PRP is a effective treatment to improve sigh and symptoms of dry eye disease. Introduction Asian studies on dry eye showed that the prevalence of dry eyes is higher in Asian population than the western population and it is between 14.5%-93.2%. 1-6 The prevalence of dry eye in India is ranging from 18.4% to 40.8%. 1-3 This variation is because of lack of uniformity in the diagnostic criteria of dry eye. There are many etiological factors for dry eye like age, sex, smoking, occupational factors, geographical factors(high altitude, hot dry air) systemic diseases like Sjögren syndrome, Meibomian glands dysfunction, air conditioning, vitamin A deficiency etc. 5,7-10 There are two main mechanisms that explain this ocular surface dysfunction: aqueous deficiency and excessive evaporation of the tear film. 11 Preservative-free artificial eye drops are the main conventional treatment for dry eye providing ocular surface lubrication. However, they lack the complex composition of natural tears such as water, salts, lipids, proteins, and growth factors. 12 http://jmscr.igmpublication. org/home/ ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi. org/10.18535/jmscr/v7i9.129
High psychological distress among school-going adolescents in Afghanistan: prevalence and correlates from a national survey

ABSTRACT The aim of this investigation was to assess the prevalence and correlates of psychological distress among adolescents Afghanistan. Cross-sectional 2014 ‘Global School-based Health Survey (GSHS)’ data included 2579 students that were representative of all students in Grades 7 to 11 in Afghanistan. The prevalence of single psychological distress was 28.4% and multiple psychological distress 27.7%. In adjusted multinomial logistic regression analysis, being female, ever cannabis and/or amphetamine use, bullying victimization and injury were associated with both single and multiple psychological distress. In addition, in unadjusted analysis, the experience of hunger, current tobacco use, secondary smoke, having been attacked, and truancy were positively and attending physical education classes was negatively associated with single and/or multiple psychological distress. High prevalence of psychological distress was observed and several risk factors identified that can facilitate intervention strategies.
Diagnostic role of IL-6 in Neonatal sepsis

Background: Neonatal sepsis is a serious life-threatening condition with high mortality. The early and accurate diagnosis of sepsis is one of main challenge for prevention of mortality due to sepsis in NICUs. A great effort to reduce the neonatal mortality rate is put into looking for new reliable biomarkers. Among various biomarkers, IL-6 could be promising and reliable biomarker for early diagnosis of neonatal sepsis. Objective: To evaluate the diagnostic value of IL-6 in Neonatal Sepsis. Design: Prospective, observational study. Methodology: By ELISA method the level of serum IL-6 were assessed in 41 neonates with suspected sepsis and 42 healthy neonates with no clinical and laboratory data of infection. Result: The AUC for IL-6 and CRP were 0.87, 0.80 respectively. The cut off value for IL-6 was 181pg/ml at which the sensitivity, specificity, PPV and NPV were 80.1%, 85.7%, 84.6%, 81.8% respectively. The cut off value for CRP is 3.78 mg/dl at which the sensitivity, specificity, PPV and NPV are 61%, 90.5%, 86.2%, 70.3% respectively. In culture positive patients sensitivity of IL-6 and CRP was 90% and 80%, respectively. In culture negative patients sensitivity of IL-6 and CRP was 71.4% and 42.8%, respectively. In EOS sensitivity of IL-6 and CRP was 86.3% and 50%, respectively. In LOS sensitivity of IL-6 and CRP was 73.6% and 72.6%, respectively. Conclusion: IL-6 is a novel biomarker with high sensitivity and good specificity for sepsis. This has better diagnostic value than CRP, especially in Blood culture negative and EOS.
Dietary Supplementation of Omega-3 Fatty Acids Influences the Equine Maternal Uterine Environment and Embryonic Development

Adverse maternal events around the time of conception influence embryonic development. Thus, aberrations in the uterine environment during early pregnancy, such as those resulting from maternal metabolic or nutritional disruption, can alter gene expression in the developing embryo, leading to variations in its developmental trajectory. Dietary supplementation of long-chain omega-3 polyunsaturated fatty acids (LCPUFA), especially Docosahexaenoic acid (DHA) improves metabolic and reproductive health across species. The objective of this study was to evaluate the effects of peri-conceptual LCPUFA supplementation on endometrial gene expression, uterine health and embryonic gene expression in overweight horses. Thirteen nonlactating light horse mares (mean ± SEM age=13.56±0.11 yr; mean ± SEM BCS=7.07±0.21) were supplemented with concentrate (n=6) or an isocaloric diet containing 0.06 g/kg BW algae-derived omega-3 LCPUFA (n=7) beginning 60 d prior to sample collection. Four consecutive ovulatory cycles were monitored, and uterine endometrial samples were obtained 12 d post-ovulation in cycles 1, 3 and 4. Mares were bred and embryos were flushed 12 d post ovulation 2,3 and 4. Endometrial biopsies obtained from supplemented mares contained increased DHA and omega-3 fatty acids as a percent of total fat (P< 0.05). Endometrial biopsy scores were assigned to endometrial tissues and mares receiving the LCPUFA supplementation had improved scores during the first ovulatory period as compared to control animals (P=0.009). Candidate genes essential to inflammation, prostaglandin synthesis and embryonic development were evaluated by quantitative reverse transcriptase polymerase chain reaction. Data were log transformed and analyzed using the GLM procedure in SAS
Quedas em idosos em ambiente domiciliar: uma revisão integrativa

Objetiva-se identificar como as quedas em idosos em ambiente domiciliar vem sendo abordadas na literatura científica nacional. Revisão integrativa realizada nas bases de dados: Base de Dados de Enfermagem (BDENF), Literatura Latino-Americana em Ciências da Saúde (LILACS) e Medical Literature Analysis and Retrieval System Online (MEDLINE). Os critérios de inclusão foram: artigos disponíveis na íntegra; publicados na língua portuguesa; no período de 2011 a 2016e que abordassem a respectiva temática. Os critérios de exclusão foram artigos repetidos nas bases de dados e quenão estivessem relacionados à enfermagem. Foram selecionados treze artigos que, a partir da essência dos conteúdos,foram agrupados em três categorias: Fatores de risco para quedas em idosos em ambiente domiciliar; Consequências das quedas em idosos no domicílio; e Prevenção de quedas em idosos: promovendo um ambiente domiciliar seguro. Conclui-se que as características intrínsecas do idoso, somadas aos vários fatores ambientais que ultrapassem sua capacidade físico-funcional, contribuem para a ocorrência da queda em idosos no domicílio, sendo necessário que o enfermeirorealize avaliações constantes dos idosos e suas vulnerabilidades para o risco de queda e oriente quanto à prática deexercícios e as adaptações da infraestrutura do ambiente domiciliar, de modo a garantir a segurança e a qualidade docuidado prestada a esses indivíduos. Palavras-chave: Acidentes por Quedas; Idoso; Habitação; Segurança do Paciente; Enfermagem Geriátrica.
The Relationship of Satisfaction, Academic Achievement, and Goal Commitment to Student Retention in a Baccalaureate Nursing Program

The problem in this investigation is retention of nursing students. The purpose is to identify, describe, and analyze existing relationships between satisfaction with college, academic achievement, and goal commitment for nursing majors in a baccalaureate nursing program that has high retention. Data were collected using two survey instruments and student grade-point averages.
Clinicopathological Pattern of Breast Cancer Presentation in Allied Hospital Faisalabad

Objective: To determine the pattern of presentation of breast cancer in Allied Hospital Faisalabad regarding age, stage, histological type, tumor grade and receptor status. Study design: An observational study. Settings: Department of Surgery Allied Hospital Faisalabad-Pakistan. Duration: January 2014 and January 2015. Methodology: 500 diagnosed breast cancer patients, who were either treated surgically or referred to Oncology department for neo adjuvant or adjuvant therapy, were included in the study after obtaining informed consent. Patients were interviewed using a questionnaire. Staging was done using triple assessment and relevant investigations and then followed for histopathology reports for histological type, grade, margin clearance and receptor status for ER, PR, and HER 2 Neu receptors. The collected data was analyzed using SPSS version 17. 0. Results: In this study, 500 patients were included with age ranging from 23 years to 80 years. 40 to 50 years is the most prevalent age group for carcinoma breast (57%). 64% females presented with advanced breast cancer (stage III and IV). Invasive ductal carcinoma is the commonest pathological type (93%). Majority (55%) of patients had grade II tumors on histopathology. Conclusion: According to this study majority of the patients presented between 40-50 years. Invasive ductal cell carcinoma is the most common type. Majority of the patients presents in advance stage.
Alcohol: The Ambiguous Molecule.

The title points to society’s contradictory views of alcohol, to the seductiveness of alcoholic beverages and to their potential for harm. Professor Edwards, who is the doyen (worldwide) of studies on alcohol policies offers here a distillation of his reflections on a variety of themes. His subjects range from a historical account of drinking, through the processes of alcohol dependence, to the mechanisms that promote recovery from dependence. …
Limiting factors in contraceptive acceptance in urban slum with or without ICDS.

Objective: To find out the difference in contraceptive acceptance in ICDS and non-ICDS areas with reference to age of wife religion and caste wife’s educational status family size and socio-economic status. Study design: Community-based cross-sectional study using pre-designed semi structured proforma. Setting: North Kolkata-Belgatchia and Dum Dum. Participants: All eligible couples living in slums in both areas who were fertile and were present at the time of interview. Sample Size: 398 using CPR of Kolkata (52.5%). Study variables: Contraceptive acceptance in ICDS and non-ICDS areas. Statistical analysis: Z test difference of proportions. Results: CPR and total contraceptive acceptances are higher in ICDS area than non-ICDS area. Terminal method was more acceptable in ICDS area while OC Pill more in non-ICDS areas. In couples where age of wives is between 30-34 years contraceptive acceptance is significantly more in ICDS area. Contraceptive acceptance among Hindus in ICDS area was more while it is more among the Muslims in non-ICDS area. In couples with illiterate wives contraceptive acceptance is significantly higher in ICDS area. In couple with 4 or more children contraceptive acceptance is significantly higher in ICDS area but in couples with less than 2 children it is more in non-ICDS area. The contraceptive acceptance in ICDS areas is significantly more in lower middle socio-economic group. Conclusion: Differences between ICDS and non-ICDS areas may not always reflect direct and consistent ‘child welfare scheme’-related benefits so far-acceptance of contraception is concerned except in case of promotion and acceptance of terminal methods. (authors)
Ligand-induced conformations of extracellular loop 2 of AT1R.

Angiotensin II type 1 receptor (AT1R) is a G-protein coupled receptor (GPCR) and an important regulator of blood pressure. It is a target for drug development, because abnormalities in its function are linked to hypertension, cardiac hypertrophy and heart failure. AT1R is composed of seven transmembrane helices connected by three extracellular loops and three intracellular loops. The extracellular loop 2 (ECL2) of AT1R directly interacts with the ligands. This loop is targeted by autoantibodies that activate AT1R in several pathologies such as preeclampsia, malignant hypertension and vascular allograft rejection. Therefore, we proposed that the conformation of ECL2 in AT1R is differentially regulated upon binding to agonists and antagonists. We determined the conformation of the ECL2 of AT1R by reporter-cysteine accessibility mapping in different receptor states (i.e., empty, agonist-bound and antagonist-bound). We introduced cysteines at each position of ECL2 of a receptor surrogate lacking all non-essential cysteines and measured reaction of these with a cysteine-reactive biotin probe. The ability of biotinylated mutant receptors to react with a
Biochemical characterisation of human KifC1 and Eg5, two potential targets for drug development in cancer chemotherapy

Kinesins are ATP-dependent molecular motors that mostly travel unidirectionally along microtubules (MTs) to fulfil their roles in intracellular transport or cell division. Those involved in cell division, known as mitotic kinesins have been implicated in a variety of cancers. As they are crucial for cell division, certain mitotic kinesins such as Eg5 and KifC1 have been considered for their potential as novel drug targets. This is with the hope that these drugs will have fewer toxic side effects than conventional cancer therapies using taxanes and vinca alkaloids. Today, several inhibitors targeting Eg5 have entered Phase I, II and III clinical trials either as monotherapies or in combination with other drugs. As new members are continually being validated, KifC1 is also becoming increasingly important as a potential new target. My PhD thesis focuses on the characterisation of human mitotic kinesins KifC1 and Eg5, two potential targets for drug development in cancer chemotherapy. The first part of this thesis (chapter 3) covers the investigation of KifC1. Firstly, the development and optimisation of the protocols for the expression and purification of several KifC1 constructs covering full-length KifC1 is presented. Then, secondary structure and biophysical characterisation of each KifC1 domain is examined. Furthermore, biochemical characterisation of KifC1 is described and the kinetic properties of each construct in relation to the biophysical data such as oligomeric state is discussed. After this, attempts to crystallise the KifC1 motor domain are described. Finally, inhibitor screening of 15,000 small molecules for KifC1-specific hits are reported. The results provide a basis for future characterisation of KifC1. The second part of this thesis (chapter 4) involves the investigation of K858, a novel inhibitor of Eg5 bearing the 1,3,4-thiadiazole scaffold, an important core moiety in many clinical drug candidates targeting a variety of diseases. Biochemical and biophysical characterisation of K858 binding to Eg5 is reported. 1.8 A resolution crystal structure of the Eg5-K858 complex (PDB ID: 6G6Y) is presented, providing the first structural evidence of how the thiadiazole containing scaffolds ARRY-520 is so successful in advancing into phase III clinical trials. Finally, structure-activity relationship (SAR) study of 22 K858 analogues is reported.
The Relationship between Psychosocial Development and Liking of Children in Nurses Working in Pediatric Clinics

Ad dress for Cor res pon den ce Müjde Çalıkuşu İncekar PhD, İstanbul Gedik University Faculty of Health Sciences, Department of Nursing, İstanbul, Turkey Phone: +90 444 54 38-1230 E-mail: mujdecalikusu@gmail.com ORCID: orcid.org/0000-0002-4472-2406 Re cei ved: 02.01. 2019 Ac cep ted: 08.02. 2019 1İstanbul Gedik University Faculty of Health Sciences, Department of Nursing, İstanbul, Turkey 2İstanbul University-Cerrahpaşa, Florence Nightingale Faculty of Nursing, İstanbul, Turkey 3Biruni University, Faculty of Health Sciences, Department of Nursing, İstanbul, Turkey 4İzmir Katip Çelebi University Faculty of Health Sciences, Department of Pediatric Nursing, İzmir, Turkey Müjde Çalıkuşu İncekar1, Ayşe İpek Yangil2, Gizem Kaya3, Gamze Genç2, Zehra Doğan4, Suzan Yıldız2
Reconstruction of Combined Full-Thickness Defect of the Lateral Canthus and Lateral Upper and Lower Third Eyelids With an Extended Modification of the Fricke Flap, Periosteal Flap, and Conjunctival Flap

Introduction: The Fricke flap was originally described in 1829 as a laterally based flap from the temporal region that could be used to reconstruct potentially total lower eyelid defects. There have been a few minor modifications of this flap to allow for adjustments of the donor site scar, but none that address the sequelae of brow elevation and allow for reconstruction of a composite defect of the lateral canthus, lateral upper, and lower eyelids. We report our modification of the Fricke flap that allows for total reconstruction of these structures. Clinical Report: A 61-year-old male presented with composite defect of the lateral eyelids and canthus following resection of a basal cell carcinoma by Mohs technique. A Fricke flap was designed and modified to included elements of the above brow and below brow skin as an additional pennant flap. A “Y” shaped periosteal flap and inferior fornix conjunctival flap were also used to reconstruct the posterior lamella. Our surgical technique and follow-up are demonstrated. Discussion: Lateral eyelid and canthal reconstruction can be difficult to reconstruct with a single rotational flap from local sources. We describe our technique of modifying the Fricke flap to include an additional pennant of below brow skin that can be used to reconstruct the lateral eyelids and canthus allowing for a crisp lateral eyelid crease and acceptable donor site and aesthetic appearance. Conclusions: This is the first description of a modification of the Fricke flap that allows for total lateral eyelid and canthus reconstruction.
Radiation-induced Myositis after Proton Beam Therapy to Huge Hepatocellular Carcinoma

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. J Liver Cancer 2019;19(2):136-142 pISSN 2288-8128 • eISSN 2383-5001 https://doi.org/10.17998/jlc.19. 2.136 Case Report
Health Care and Cleanliness in Tertiary Care Hospitals in Peshawar, Khyber Pakhtunkhwa

The present study was conducted to probe the cleanliness in the tertiary healthcare hospitals in Peshawar-Pakistan. The data was collected through a structured questionnaire from 600 sampled respondents admitted in three tertiary healthcare hospitals in Peshawar i.e. Khyber Teaching hospital, Hayatabad Medical Complex and Lady Reading Hospital through proportional allocation method. The patients were very critical about the healthcare and cleanliness in the above three major hospitals of Khyber Pakhtunkhwa. The Bi-variate analysis was made and the results reveal that hospital has clean and hygienic environment (P=0.006), Medical OPD,s were clean and tidy (P=0.000) , wards were clean and well maintained (P=0.000), Toilets were clean and well maintained (P=0.000). The study recommended that hospital administration should keep focus on cleanliness in washroom, clean water and clean food to the patients.