Miracle-dz/UniFAR-FTUs huggingface dataset:
Perspective: Gestational Tryptophan Fluctuation Altering Neuroembryogenesis and Psychosocial Development

Tryptophan, as the sole precursor of serotonin, mainly derived from diets, is essential for neurodevelopment and immunomodulation. Gestational tryptophan fluctuation may account for the maternal-fetal transmission in determining neuroembryogenesis with long-lasting effects on psychological development. Personality disorders and social exclusion are related to psychosocial problems, leading to impaired social functioning. However, it is not clear how the fluctuation in mother-child transmission regulates the neuroendocrine development and gut microbiota composition in progeny due to that tryptophan metabolism in pregnant women is affected by multiple factors, such as diets (tryptophan-enriched or -depleted diet), emotional mental states (anxiety, depression), health status (hypertension, diabetes), and social support as well as stresses and management skills. Recently, we have developed a non-mammal model to rationalize those discrepancies without maternal effects. This perspective article outlines the possibility and verified the hypothesis in bully-victim research with this novel model: (1). Summarizes the effects of the maternal tryptophan administration on the neuroendocrine and microbial development in their offspring; (2). Highlights the inconsistency and limitations in studying the relationship between gestational tryptophan exposure and psychosocial development in humans and viviparous animals; and (3). Evidences that embryonic exposure to tryptophan and its metabolite modify bullying interactions in the chicken model. With the current pioneer researches on the biomechanisms underlying the bully-victim interaction, the perspective article provides novel insights for developing appropriate intervention strategies to prevent psychological disorders among individuals, especially those who experienced prenatal stress, by controlling dietary tryptophan and medication therapy during pregnancy.
Development and semantic validation of an instrument for the assessment of knowledge and attitudes towards cardiopulmonary resuscitation in adolescents

Abstract Objective. Develop and semantically validate an instrument to assess the knowledge and attitudes of adolescents towards cardiopulmonary resuscitation (CPR). Methods. Validation study of an instrument to evaluate the knowledge and attitudes of adolescents towards CPR, developed in three phases: (i) development of the evaluation instruments by the authors; (ii) content validation performed by 14 expert judges in the area using the content validity index for analysis; and (iii) semantic validation carried out with the participation of 30 adolescents between 11 and 13 years old. Results. In the content validation, the questions on CPR knowledge obtained a content validity index (CVI) between 0.92 and 1.00, with a general index of 0.98; and the questions about attitudes obtained an IVC between 0.85 and 1.00, with a general index also of 0.98. Regarding semantic validation, three questions were modified in the knowledge assessment instruments and five in the attitude assessment instrument. Conclusion. Semantic and content validation of the instruments studied showed that they are suitable for assessing the knowledge and attitudes of adolescents related to CPR, so their use is recommended in the evaluation of training actions in this population group.
Environmental aspects of the production and use of autoclaved aerated concrete with low density

The purpose of the article is to investigate the state of carbon dioxide emissions generated as a result of wall materials production and the construction industry as a whole. The paper provides a comparative analysis of housing construction in Ukraine and in some CIS countries. Against the background of the indicators of low housing availability and low relative volumes of housing construction, the issue of high energy consumption remains valid. The absolute and relative volumes of greenhouse gas emissions from economic activity of the population of Ukraine are given. The projected consequences for Ukraine from continued CO2 emissions on the same level and temperature rise are estimated. It is deemed that the most suitable wall material for countries with emerging economies is autoclaved aerated concrete (AAC); since it is a structural and thermal insulating material, it can solve the problem of housing construction. The paper shows the key priority of low energy consumption and makes emphasis on lowering the density of the produced aerated concrete, reducing mineral additives and cement production expenses.
Sex, Gender, and Alcohol Use: Implications for Women and Low-Risk Drinking Guidelines

Alcohol use is coming under increasing scrutiny with respect to its health impacts on the body. In this vein, several high-income countries have issued low-risk drinking guidelines in the past decade, aiming to educate the public on safer levels of alcohol use. Research on the sex-specific health effects of alcohol has indicated higher damage with lower amounts of alcohol for females as well as overall sex differences in the pharmacokinetics of alcohol in male and female bodies. Research on gender-related factors, while culturally dependent, indicates increased susceptibility to sexual assault and intimate partner violence as well as more negative gender norms and stereotypes about alcohol use for women. Sex- and gender-specific guidelines have been issued in some countries, suggesting lower amounts of alcohol consumption for women than men; however, in other countries, sex- and gender-blind advice has been issued. This article reports on a synthesis of the evidence on both sex- and gender-related factors affecting safer levels of drinking alcohol with an emphasis on women’s use. We conclude that supporting and expanding the development of sex- and gender-specific low-risk drinking guidelines offers more nuanced and educative information to clinicians and consumers and will particularly benefit women and girls.
Analysis of Fan Stage Design Attributes for Boundary Layer Ingestion

This paper describes a new conceptual framework for three-dimensional turbomachinery ﬂow analysis and its use to assess fan stage attributes for mitigating adverse effects of inlet distortion due to boundary layer ingestion (BLI). A non-axisymmetric throughﬂow method has been developed to describe the fan ﬂow ﬁeld with inlet distortion. In this the turbomachinery is modeled using momentum and energy source distributions that are determined as a function of local ﬂow conditions and a speciﬁed blade camber surface geometry. Comparison with higher-ﬁdelity computational and experimental results shows that the method captures the principal ﬂow redistribution and distortion transfer effects associated with BLI. Distortion response is assessed for a range of (i) rotor spanwise work proﬁles, (ii) rotor-stator spacings, and (iii) non-axisymmetric stator geometries. For the parameters examined, changes in axisymmetric design result in trades between rotor and stator distortions, or between different radial sections of a given blade row with marginal overall gain. Of the approaches examined, non-axisymmetric stator exit ﬂow angle distributions were found to provide the greatest reduction in rotor ﬂow distortion and thus may offer the most potential for mitigating decreases in performance due to BLI inlet distortion.
Application of Artificial Neural Network to Predict the Resilient Modulus of Stabilized Base Subjected to Wet-Dry Cycles

One of the most important input parameters for design of pavement structure based on mechanistic-empirical method is resilient modulus of different pavement materials. This research aims to provide a model for predicting resilient modulus of stabilized base subjected to wet-dry cycles based on Artificial Neural Network (ANN). Dataset for developing ANN consists of a total of 704 records and five attributes which is adopted from Maalouf et al. (2012). A Feed-Forward back propagation neural network was employed to predict resilient modulus of stabilized base with respect to five input parameters including the number of W-D cycles, the ratio of free lime to SAF (Silica, Alumina and Ferric Oxide compounds in the cementitious materials), the ratio of maximum dry density to the optimum moisture content, confining stress and the deviator stress. The results show that the artificial neural network can be used as a powerful and accurate tool to predict the resilient modulus of stabilized base in presence of wet-dry cycles. Also comparison of ANN with Support Vector Machine (SVM) confirms that the accuracy of ANN is superior to SVM method.
Volatile Compound Production and Quality Characteristics of Durian Fruit Cv. Monthong as Affected by 1-methylcyclopropene and Modified Atmosphere Storage

ABSTRACT This study aimed to evaluate the combined effects of 1-methylcyclopropene (1-MCP) and modified atmosphere (MA) storage on volatile compound production and quality parameters of durian fruit cv. Monthong during storage. Whole durian fruit harvested at the commercial maturity (75–80%) was fumigated with 0–1,000 nL L−1 of 1-MCP for 12 hours. The fruits were then kept in MA chamber fitted with a silicone membrane window at 15°C up to 4 weeks. Volatile aroma compounds including 3 sulfur compounds, 1 ester, 5 alcohols, and 1 ketone were monitored during durian fruit storage. The production of diethyl disulfide, 3,5-dimethyl-1,2,4-trithiolane (2 isomers) and ethyl-2-methyl butanoate was strongly suppressed by 1-MCP/MA treatment. Husk and pulp color changes, pulp softening, respiration rate, production of ethylene, and fermentative metabolites were effectively retarded with 1-MCP/MA technique. 1-MCP treatment at 500 nL L−1 for 12 h under MA condition could extend the storage life of Monthong durian fruit up to 3 weeks without any negative effect. Therefore, this combined technique could be applied to maintain quality and control the ripening process of Monthong durian fruit.
Cutaneous and Subcutaneous Tumours of Small Pet Mammals—Retrospective Study of 256 Cases (2014–2021)

Simple Summary Several species of small mammals are very popular as companion pet animals and therefore demand professional veterinary care, including proper diagnostic and treatment procedures. The incidence of neoplastic diseases in companion pet animals has increased over time, as it has in humans. The aim of this study was to evaluate the incidence of cutaneous tumours in small mammal pets, including guinea pigs, rats, pet rabbits, ferrets, hamsters, degus, African pygmy hedgehogs, Mongolian gerbils and chinchillas, submitted for histopathology in 2014–2021. Malignant tumours represented the predominant group of cutaneous tumours in rats, African pygmy hedgehogs, degus and chinchillas, and represented a significant percentage of lesions in guinea pigs, pet rabbits, ferrets, hamsters and Mongolian gerbils. We also described the first case of melanocytoma in a pet rabbit, epitheliotropic T-cell lymphoma in a degu, cutaneous histiocytic sarcoma in a Mongolian gerbil, fibrosarcoma in two chinchillas and epithelioid haemangioma in a chinchilla. The incidence of malignant neoplasms among spontaneous integumentary tumours submitted for histopathology is high in many species of small mammal pets. Therefore, each cutaneous tumour should be sampled for further diagnosis and treatment. Abstract Since small mammals are gaining popularity as pets in Poland, the number of tumour samples submitted for histopathological examination is quite high. This study was a retrospective analysis of cutaneous and subcutaneous tumours in small pet mammals submitted for histopathology in 2014–2021. The analysis included 256 tumours sampled from 103 guinea pigs, 53 rats, 43 pet rabbits, 21 ferrets, 17 hamsters, 8 degus, 5 African pygmy hedgehogs, 3 Mongolian gerbils and 3 chinchillas. Tumours were diagnosed based on routine histopathology, with additional immunohistochemistry when necessary. The results of this study revealed that the vast majority of cutaneous tumours in guinea pigs were benign, with a predominance of lipoma. Adnexal tumours constituted a significant percentage of cutaneous tumours in guinea pigs (24.3%, with the most common being trichofolliculoma), pet rabbits (46.5%, with the most common being trichoblastoma), ferrets (33.3%, mostly derived from sebaceous glands), hamsters (52.9%, with the most common being trichoepithelioma) and gerbils (66.7%, scent gland epithelioma). Soft tissue sarcomas were a predominant group of tumours in rats (52.8%, with the most common being fibrosarcoma), African pygmy hedgehogs (100%), degus (87.5%) and chinchillas (66.7%). Melanocytic tumours were only sporadically seen in small mammal pets. Mast cell tumours were diagnosed only in ferrets, while epitheliotropic T-cell lymphoma was diagnosed only in a hamster and a degu. In summary, malignant tumours constitute a significant percentage of cutaneous tumours in many species of small mammal pets. Therefore, each cutaneous tumour should be sampled for further cytologic or histopathologic diagnosis.
Trends in the Frequency of Water and Heat Stress in Mid-Latitude North America since 1980

: The water-energy balance of many mid-latitude watersheds has been changing in recent decades due to global warming. These changes manifest themselves over both long timescales (e.g., hydrologic drought) and short timescales (e.g., agricultural drought) and may be ameliorated or exacerbated by vegetative response. We apply a Budyko framework to assess short-term response to long-term trends in water and heat stress (HS) across mid-latitude North America. Using high-resolution meteorological data and streamﬂow records, we calculate the frequency of HS every year since 1980 for every gaged watershed with adequate data ( n = 1528). We ﬁnd that HS has become more frequent in most watersheds in the western US, New England, and southeastern Canada. However, we ﬁnd that HS has become less frequent in the Midwest and the relatively humid eastern US. By assessing the relationship between trends in HS frequency and proximate forcing variables (annual PPT, annual streamﬂow, minimum and maximum daily temperatures, actual evapotranspiration, and potential evapotranspiration), we ﬁnd that these trends in HS frequency are primarily driven by meteorological forcings rather than vegetative response. Finally, we contextualize our ﬁndings within the Budyko framework, which assumes a landscape in equilibrium with its climate, with the implication that these trends in HS are only likely to be realized after local vegetation has adapted to new meteorological norms.
Customer adoption of self-service technologies in Jordan: Factors influencing the use of Internet banking, mobile banking, and telebanking

Self-service technologies (SSTs) are systems that enable customers to independently access banking services at a time and place of their choosing. Such technologies have been widely incorporated into banking logistical systems to increase the geographical coverage, reduce labor costs and provide customers with a better service, thereby enhancing their satisfaction and loyalty. The fundamental aim of this research is to propose and examine a conceptual model that best explains the key factors influencing Jordanian customers' intentions and usage of SST banking channels: Internet banking, Mobile banking, and Telebanking. The conceptual model proposed was based on the Unified Theory of Acceptance and Use of Technology (UTAUT2). This was extended by adding perceived risk as an external factor. A quantitative approach was selected and data gathered from 348 bank customers was analyzed through Structural equation modelling (SEM) was conducted using AMOS 21. The results show that behavioral intention is significantly influenced by performance expectancy, hedonic motivation, price value and perceived risk; however, social influences do not have a significant influence on behavioral intention. This study makes an important contribution by applying UTAUT2 to examine new technology (SSTs) in a new context (Jordan).
A Multicenter, Prospective, Observational Study to Assess the Clinical Activity and Impact on Symptom Burden and Patients’ Quality of Life in Patients with Advanced Soft Tissue Sarcomas Treated with Trabectedin in a Real-World Setting in Greece

Simple Summary Soft tissue sarcomas (STS) constitute a group of heterogeneous tumors. For patients with advanced or metastatic disease, prognosis is poor and only a few treatments are available, including trabectedin. The aim of our prospective multicenter study was to evaluate the real-world activity of trabectedin, and its impact on symptom burden and quality of life in patients with advanced STS treated in routine clinical settings in Greece. Between 21 December 2015 and 6 June 2018, 64 eligible patients from 13 Greek centers were evaluated. Our study provides real-world evidence on the effectiveness, tolerability and safety of trabectedin in a population of patients with advanced STS of multiple histological subgroups who have either experienced a relapse or disease progression after standard-of-care front-line therapy, or were unsuited to receive front-line agents. Abstract This non-interventional, multicenter, prospective study aimed to evaluate the real-world activity of trabectedin, and its impact on symptom burden and quality of life in patients with advanced soft tissue sarcoma (aSTS) treated in routine clinical settings in Greece. Patients with histologically confirmed aSTS newly initiated on trabectedin were enrolled. The primary endpoint was progression-free survival (PFS) rate at 6 months. Secondary endpoints included PFS rate at 3 months, median PFS, objective response rate (ORR), disease control rate (DCR), overall survival (OS), and an assessment of the impact of treatment on health-related quality of life (HRQoL), cancer-related symptom burden and symptom interference with function, as well as all-cause treatment discontinuation rate. A total of 64 eligible patients from 13 Greek centers were evaluated. Patients received a median of three trabectedin cycles per patient (interquartile range [IQR]: 2.0–6.0). Median PFS was 6.6 months with 67.9% and 51.2% of patients free from progression at 3 and 6 months, respectively. ORR was 7.8% and DCR 21.9%. Median OS was 13.1 months. No significant changes from enrolment were noted in HRQoL scores. In total, 30 patients (46.9%) had at least one trabectedin-related adverse drug reaction (ADR) and 9 (14.1%) at least one serious ADR. The treatment discontinuation rate due to toxicity was 9.4%. These results suggest that trabectedin is an active treatment with clinically meaningful benefits in patients with aSTS with no new safety signals.
Steuerung der Erstarrungsmorphologie austenitisch-ferritischer Superduplex-Stähle

Les aciers superduplex austeno-ferritiques. Conduite des etudes: affinement de grain sur et reproductible des aciers superduplex; etude systematique de la precipitation de la phase σ en fonction de la grosseurde grain; etude de l'influence de la precipitation de la phase σ sur la naissance des tensions internes au cours du refroidissement. Resultats des essais: la structure des eprouvettes a affinage de grain; leurs proprietes mecaniques: resistance a la traction et tenacite a l'ambiante et aux temperatures elevees; caracteristiques de precipitation: prevision de la precipitation de la phase σ; cinetique de la precipitation de la phase a en fonction de la grosseur de grain sous conditions isothermes et continues; Tensions internes. Conclusions et perspectives.
PENGARUH PROFITABILITAS, LIKUIDITAS DAN UKURAN PERUSAHAAN TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN MANUFAKTUR

The objective of this research is to obtain empirical evidence on the influence of profitability, liquidity and firm size toward firm value. This research uses data from manufacturing companies listed on the Indonesia Stock Exchange during 2015-2017. The results of this research indicate that profitability, liquidity and firm size have a significant influence on firm value. To further research, make the sample count bigger, use companies that include not only manufacturing companies and use variabels that have not been used that may influence companies firm value.
A high reliability metal insulator metal capacitor for 0.18 /spl mu/m copper technology

A high reliability Metal-Insulator-Metal capacitor integrated into a 0.18 /spl mu/m CMOS foundry technology using Copper interconnects is discussed. Integration solutions specific to Copper processing are described and process yield and reliability results are presented on 0.72 fF//spl mu/m/sup 2/ capacitors. Performance and reliability metrics are shown to be comparable to those formed on Aluminum technologies.
Crecimiento y característica s de la canal de corderos finalizados con clorhidrato de zilpaterol en pastoreo de alfalfa Growth and carcass characteristics of lambs finished with zilpaterol hydrochloride in grazing alfalfa

The objective of the study was to evaluate the effect of zilpaterol hydrochloride (ZH) on the weight gain and carcass characteristics in lambs finished in alfalfa pasture and supplemented with concentrate in pen. A total of 24 Dorper x Pelibuey ram lambs initially weighting 25.0±0.24 kg were divided in two groups (n=12) and fed with 0 or 10 mg/ head/d of ZH for the last 30 d before slaughter. During the experimental period, all lambs were grazed in alfalfa during 8 h/d and supplemented with 450 g/d of concentrate. The ZH did not affect (P>0.05) the live weight. Daily and total weight gains were similar (P>0.05) between both groups. Carcass characteristics and wholesale cut yields were not affected (P>0.05) by ZH. In conclusion, growth and carcass characteristics were not improved by feeding zilpaterol (10 mg/head/d) in finished lambs on alfalfa grassland and supplemented with concentrate.
Successful Treatment of Immune Thrombocytopenic Purpura with Intracranial Hemorrhaging and Duodenal Bleeding Following SARS-CoV-2 Vaccination

Several vaccines have been developed for coronavirus disease 2019 - caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - in record time. A few cases of immune thrombocytopenic purpura (ITP) following SARS-CoV-2 vaccination have been reported. We herein report a 90-year-old man who received the Pfizer-BioNTech SARS-CoV-2 vaccine (BNT162b2) and developed severe thrombocytopenia with intracranial hemorrhaging and duodenal bleeding, consistent with vaccine-related ITP. He was successfully treated with intravenous immunoglobulin, prednisolone, and eltrombopag and discharged without cytopenia. Vaccine-related ITP should be suspected in patients presenting with abnormal bleeding or purpura after vaccination.