Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancing Fairness Perception – Towards Human-Centred AI and Personalized Explanations Understanding the Factors Influencing Laypeople’s Fairness Perceptions of Algorithmic Decisions

Abstract Whether we like it or not, algorithmic decision-making systems (ADMSs) are all around us. These systems assist both public institutions and private organizations in making decisions that exert a significant impact on our lives. The widespread use of artificial intelligence (AI) and machine learning (ML) systems and the potential risks of using them are the subjects of intensive, ongoing research. It is imperative to ensure their fairness and transparency. The understanding that ADMSs should be subject to human supervision and examined for laypeople’s perceived fairness is clear. Laypeople’s perceptions regarding ADMSs’ fairness, their understanding of the reasons underlying the systems’ outcome (decision), and their comprehension of the linkage between the explanations and the results, influence their willingness to trust the systems, use them and accept their decisions. To determine and better understand which factors affect laypeople’s perceptions of the fairness of algorithmic decisions, we conducted an online between-subject experiment, employing a case study of a simulated AI-based recruitment decision-support system. We focused on three aspects: system characteristics (SC), personality characteristics (PC), and demographic characteristics (DC). We conducted an in-depth analysis to determine which explanation increases the perceived fairness the most. Based on the results, we suggest a framework for predicting a layperson’s perception of the fairness of the explanations. Our findings may help in understanding how to involve humans in the development and evaluation process of ADMSs, how to create personalized explanations based on the SC as well as on users’ PC and DC, and, consequently, how to enhance laypeople’s fairness perceptions regarding ADMSs.
ERK5 Is a Major Determinant of Chemical Sarcomagenesis: Implications in Human Pathology

Simple Summary Sarcoma is a heterogeneous group of tumors poorly studied with few therapeutic opportunities. Interestingly, the role of MAPKs still remains unclear in sarcomatous pathology. Here, we describe for the first time the critical role of ERK5 in the biology of soft tissue sarcoma by using in vitro and in vivo approaches in a murine experimental model of chemical sarcomagenesis. Indeed, our observations were extrapolated to a short series of human leiomyosarcoma and rhabdomyosarcomas. Furthermore, transcriptome analysis allows us to demonstrate the critical role of KLF2 in the biological effects of ERK5. Therefore, the data presented here open new windows in the diagnosis and therapy of soft tissue sarcomas. Abstract Sarcomas are a heterogeneous group of tumors in which the role of ERK5 is poorly studied. To clarify the role of this MAPK in sarcomatous pathology, we used a murine 3-methyl-cholanthrene (3MC)-induced sarcoma model. Our data show that 3MC induces pleomorphic sarcomas with muscle differentiation, showing an increased expression of ERK5. Indeed, this upregulation was also observed in human sarcomas of muscular origin, such as leiomyosarcoma or rhabdomyosarcoma. Moreover, in cell lines derived from these 3MC-induced tumors, abrogation of Mapk7 expression by using specific shRNAs decreased in vitro growth and colony-forming capacity and led to a marked loss of tumor growth in vivo. In fact, transcriptomic profiling in ERK5 abrogated cell lines by RNAseq showed a deregulated gene expression pattern for key biological processes such as angiogenesis, migration, motility, etc., correlating with a better prognostic in human pathology. Finally, among the various differentially expressed genes, Klf2 is a key mediator of the biological effects of ERK5 as indicated by its specific interference, demonstrating that the ERK5–KLF2 axis is an important determinant of sarcoma biology that should be further studied in human pathology.
Recognition of Glycometabolism-Associated lncRNAs as Prognosis Markers for Bladder Cancer by an Innovative Prediction Model

The alteration of glycometabolism is a characteristic of cancer cells. Long non-coding RNAs (lncRNAs) have been documented to occupy a considerable position in glycometabolism regulation. This research aims to construct an effective prediction model for the prognosis of bladder cancer (BC) based on glycometabolism-associated lncRNAs (glyco-lncRNAs). Pearson correlation analysis was applied to get glyco-lncRNAs, and then, univariate cox regression analysis was employed to further filtrate survival time-associated glyco-lncRNAs. Multivariate cox regression analysis was utilized to construct the prediction model to divide bladder cancer (BC) patients into high- and low-risk groups. The overall survival (OS) rates of these two groups were analyzed using the Kaplan–Meier method. Next, gene set enrichment analysis and Cibersortx were used to explore the enrichment and the difference in immune cell infiltration, respectively. pRRophetic algorithm was applied to explore the relation between chemotherapy sensitivity and the prediction model. Furthermore, reverse transcriptase quantitative polymerase chain reaction was adopted to detect the lncRNAs constituting the prediction signature in tissues and urine exosomal samples of BC patients. A powerful model including 6 glyco-lncRNAs was proposed, capable of suggesting a risk score for each BC patient to predict prognosis. Patients with high-risk scores demonstrated a shorter survival time both in the training cohort and testing cohort, and the risk score could predict the prognosis without depending on the traditional clinical traits. The area under the receiver operating characteristic curve of the risk score was higher than that of other clinical traits (0.755 > 0.640, 0.485, 0.644, or 0.568). The high- and low-risk groups demonstrated very distinct immune cells infiltration conditions and gene set enriched terms. Besides, the high-risk group was more sensitive to cisplatin, docetaxel, and sunitinib. The expression of lncRNA AL354919.2 featured with an increase in low-grade patients and a decrease in T3-4 and Stage III–IV patients. Based on the experiment results, lncRNA AL355353.1, AC011468.1, and AL354919.2 were significantly upregulated in tumor tissues. This research furnishes a novel reference for predicting the prognosis of BC patients, assisting clinicians with help in the choice of treatment.
Effects of PCSK9 inhibitors on HDL cholesterol efflux and serum cholesterol loading capacity in familial hypercholesterolemia subjects: a multi-lipid-center real-world evaluation

Proprotein convertase subtilisin/kexin type 9 (PCSK9), beyond regulating LDL cholesterol (LDL-c) plasma levels, exerts several pleiotropic effects by modulating lipid metabolism in extrahepatic cells such as macrophages. Macrophage cholesterol homeostasis depends on serum lipoprotein functions, including the HDL capacity to promote cell cholesterol efflux (CEC) and the serum capacity to promote cell cholesterol loading (CLC). The aim of this observational study was to investigate the effect of PCSK9 inhibitors (PCSK9-i) treatment on HDL-CEC and serum CLC in patients with familial hypercholesterolemia (FH). 31 genetically confirmed FH patients were recruited. Blood was collected and serum isolated at baseline and after 6 months of PCSK9-i treatment. HDL-CEC was evaluated through the main pathways with a radioisotopic cell-based assay. Serum CLC was assessed fluorimetrically in human THP-1 monocyte-derived macrophages. After treatment with PCSK9-i, total cholesterol and LDL-c significantly decreased (−41.6%, p < 0.0001 and −56.7%, p < 0.0001, respectively). Total HDL-CEC was not different between patients before and after treatment. Conversely, despite no changes in HDL-c levels between the groups, ABCG1 HDL-CEC significantly increased after treatment (+22.2%, p < 0.0001) as well as HDL-CEC by aqueous diffusion (+7.8%, p = 0.0008). Only a trend towards reduction of ABCA1 HDL-CEC was observed after treatment. PCSK9-i significantly decreased serum CLC (−6.6%, p = 0.0272). This effect was only partly related to the reduction of LDL-c levels. In conclusion, PCSK9-i treatment significantly increased HDL-CEC through ABCG1 and aqueous diffusion pathways and reduced the serum CLC in FH patients. The favorable effect of PCSK9-i on functional lipid profile could contribute to the cardiovascular benefit of these drugs in FH patients.
Pregnancies and contraceptive use in four African countries during the COVID-19 pandemic

The COVID-19 pandemic and the public health measures adopted in response to it have triggered plenty of speculation about the potential impact on fertility in different regions of the globe. This study provides evidence on the fertility response in four sub-Saharan African countries during the first year of the pandemic. Using harmonized data on women of childbearing age from the Performance Monitoring for Action (PMA) data series, this study compares pregnancy rates at the turn of the year 2020/21 to a pre-pandemic baseline. There is no indication of a general increase in pregnancy rates after the beginning of the pandemic. In some of the sample countries, pregnancy rates during this phase of the COVID-19 pandemic instead fell significantly among the youngest and the least educated women of childbearing age, respectively. The findings also indicate that over this period, rates of modern contraceptive usage rose significantly among the surveyed female populations in several sample countries.
Late Carboniferous intrusions along the Kalamaili suture zone, southwestern Central Asian Orogenic Belt (CAOB): implications for a tectonic switch from subduction to collision

ABSTRACT A tectonic switch from subduction to collision and/or arc–arc collision is a key issue for understanding accretionary orogenic processes. We present new U-Pb ages, geochemistry, whole-rock Nd and zircon Hf isotope data for a suite of late Carboniferous intrusive rocks along the Kalamaili suture zone of the southwestern Central Asian Orogenic Belt (CAOB) and demonstrate their petrogenesis and the transition of their tectonic settings. Zircon U-Pb dating for the gabbros, diorites, granodiorites, and monzogranites yields ages of 317–301 Ma. The gabbros (311 Ma) were likely derived from partial melting of a mixed source of depleted MORB-like asthenospheric mantle with minor old crustal material; the diorites (301 Ma) from the mixed depleted lithospheric mantle and crustal components; the granodiorites (303 Ma) from the mixed mantle- and crust-derived magmas; and the monzogranites (317 Ma) from melting of the newly underplated basaltic lower crust. Combined with previous data, we have grouped all the intrusive rocks along the Kalamaili suture zone into three phases: 350–340 Ma, 330–320 Ma, and 320–300 Ma. The first phase consists of tholeiitic and high-K calc-alkaline granites, the second phase is composed of high-K calc-alkaline I-type granites with strong deformation, and the third phase comprises voluminous and various rock types (mainly mafic and felsic, including many A-type granites), revealing a magmatic flare-up. The magmatic associations and evolution from the first to the third phase, together with regional geology, suggest a tectonic transition from subduction/accretion (350–340 Ma) through syn-collision (330–320 Ma) to post-collision (or post-accretionary, 320–300 Ma), respectively. This study provides new magmatic evidence for the switch from subduction to collision (arc-arc collision) along the Kalamaili suture zone in the southwestern CAOB.
RIGHTS-BASED PEDAGOGY AND EARLY CHILDHOOD EDUCATION PRACTICES

A rights-based pedagogy is based on the principles of human rights. In education, specifically in childhood education, a pedagogy that guarantees the rights of the child must be based on the Convention on the Rights of the Child and the other legal issues. A rights-based approach is based on seven fundamental principles: dignity; interdependence and indivisibility; best interests; participation; non-discrimination; transparency and accountability; life, survival, and development. This research focuses on the participation of children in an educational context, from an interpersonal perspective and as a transformative process. It aims to analyse the state of the art on the educator's role in promoting children's participation. This is a systematic literature review supported by a hermeneutic analysis to proceed with its categorization and interpretation. The investigative process followed the following steps: (i) search databases by keywords; (ii) selection of relevant articles; (iii) read the texts, organizing them in a diachronic way; (iv) elaborate on categories of analysis; (v) textual elaboration, performing the intersection between pedagogy based on rights and participation. The study shows that the right of participation of children is still far from being achieved, although children's rights are present in national and international official documents for education. Their voice is not always heard and their influence on learning processes is barely visible. The study concludes that children's participation in an educational context is only guaranteed when there are practices based on rights-based pedagogies.
Feasibility of Virtual Reality Exercises at Home for Post–COVID-19 Condition: Cohort Study

Background Between 30% to 76% of COVID-19 patients have persistent physical and mental symptoms, sometimes up to 9 months after acute COVID-19. Current rehabilitation is mostly focused on the physical symptoms, whereas experts have agreed on the need for a biopsychosocial approach. A novel approach such as virtual reality (VR) rehabilitation at home might benefit patients and therapists, especially considering the expected rush of patients with post–COVID-19 condition needing rehabilitation. Objective The aim of this study was to investigate the feasibility of self-administered VR exercises at home for post–COVID-19 condition. Methods This was a single-arm feasibility study in an outpatient care setting. Patients who needed physiotherapy because of post–COVID-19 condition were included as determined by the treating physiotherapist. Participants performed VR physical exercises at home for a period of 6 weeks and were allowed to perform VR mental exercise through applications available on the VR platform to reduce stress and anxiety and promote cognitive functioning. The main outcomes were related to feasibility (ie, duration and frequency of VR use), safety (ie, adverse events), patient satisfaction, and reasons to withdraw. Physical performance, daily activities, cognitive functioning, anxiety and depression, and the quality of life were measured before and after. Results In total, 48 patients were included; 1 (2%) patient did not start VR, and 7 (15%) patients withdrew, mostly due to dizziness. Almost 70% (33/47) of participants reported experiencing any adverse event during VR exercising. However, only 25% (9/36) recalled these events at the end of the intervention period. The majority (27/36, 75%) of the patients described VR as having a positive influence on their recovery, and the global satisfaction score was 67%. The average VR use was 30 minutes per session, 3-4 times a week for 3-6 weeks. The overall use of VR applications was almost equally distributed over the 3 sets of VR exercises (physical, relaxing, and cognitive). However, the use frequency of physical exercises seemed to decrease over time, whereas the use of cognitive and relaxation exercises remained stable. Physical performance and quality of life outcomes were significantly improved after 6 weeks. Conclusions VR physical exercises at home is feasible and safe with good acceptance in a significant percentage of patient with post–COVID-19 condition. Trial Registration ClinicalTrials.gov NCT04505761; https://clinicaltrials.gov/ct2/show/NCT04505761
Different Neutralization Profiles After Primary SARS-CoV-2 Omicron BA.1 and BA.2 Infections

Background and Methods The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) Omicron (B.1.1.529) variant is the antigenically most distinct variant to date. As the heavily mutated spike protein enables neutralization escape, we studied serum-neutralizing activities of naïve and vaccinated individuals after Omicron BA.1 or BA.2 sub-lineage infections in live virus neutralization tests with Omicron BA.1, Omicron BA.2, wildtype (WT, B1.1), and Delta (B.1.617.2) strains. Serum samples obtained after WT infections and three-dose mRNA vaccinations with and without prior infection were included as controls. Results Primary BA.1 infections yielded reduced neutralizing antibody levels against WT, Delta, and Omicron BA.2, while samples from BA.2-infected individuals showed almost no cross-neutralization against the other variants. Serum neutralization of Omicron BA.1 and BA.2 variants was detectable after three-dose mRNA vaccinations, but with reduced titers. Vaccination-breakthrough infections with either Omicron BA.1 or BA.2, however, generated equal cross-neutralizing antibody levels against all SARS-CoV-2 variants tested. Conclusions Our study demonstrates that although Omicron variants are able to enhance cross-neutralizing antibody levels in pre-immune individuals, primary infections with BA.1 or BA.2 induced mostly variant-specific neutralizing antibodies, emphasizing the differently shaped humoral immunity induced by the two Omicron variants. These data thus contribute substantially to the understanding of antibody responses induced by primary Omicron infections or multiple exposures to different SARS-CoV-2 variants and are of particular importance for developing vaccination strategies in the light of future emerging variants.
Covalent core-radiolabeling of polymeric micelles with 125I/211At for theranostic radiotherapy

Astatine-211 (211At) is one of the most promising α-emitters for targeted alpha therapy, especially of cancer metastases. However, the lack of a stable isotope, frequent in vivo deastatination, and limited radiochemical knowledge makes it challenging to apply. Here, we report a new strategy for radiolabeling the lipophilic core of polymeric micelles (PMs) with covalently bound 211At. The PMs were radiolabeled via either an indirect synthon-based method or directly on the amphipathic block copolymer. The radiochemistry was optimized with iodine-125 (125I) and then adapted for 211At, enabling the use of both elements as a potential theranostic pair. PMs that were core-radiolabeled with both 125I or 211At were prepared and characterized, based on a PEG(5k)-PLGA(10k) co-polymer. The stability of the radiolabeled PMs was evaluated in mouse serum for 21 h, showing radiochemical stability above 85%. After in vivo evaluation of the 211At- labeled PMs, 4-5 % ID/g of the 211At could still be detected in the blood, showing a promising in vivo stability of the PMs. Further, 211At-labeled PMs accumulated in the spleen (20-30 %ID/g) and the liver (2.5- 5.5 %ID/g), along with some detection of 211At in the thyroid (3.5-9 %ID/g). This led to the hypothesis that deastatination takes place in the liver, whereas good stability of the 211At core-radiolabel was observed in the blood.
The use of sintered silver-hydroxyapatite powder added electrodes in electrical discharge machining of Ti-6Al-4 V

Al and V ion release from the Ti-6Al-4 V implants due to the long-term interactions with body fluids can cause diseases such as Alzheimer’s, neuropathy, and osteomalacia. Therefore, it is aimed to increase the bonding and biocompatibility between bone and implant by changing the surface roughness, topography, and chemical composition of Ti-6Al-4 V alloy with different physical, chemical, and mechanical methods. The study proposes to obtain a porous surface coated with Ag-Ca-P on a Ti-6Al-4 V workpiece by the use of sintered silver-hydroxyapatite powder added to electrodes in Electrical Discharge Machining. Micronized silver and hydroxyapatite powders were mixed in different proportions by volume using the powder metallurgy method to achieve the proposed aims. A parametric experimental study was conducted and the surface properties of the treated samples were analyzed by optical microscopy, scanning electron microscopy, energy dispersion spectroscopy, and X-ray diffractometry. The results have confirmed the formation of a porous silver-hydroxyapatite-rich layer on the electrical discharged machined Ti-6Al-4 V surfaces. Therefore, it has been concluded that electrical discharge machining is a promising alternative method for obtaining biocompatible functional surfaces.
The Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing

Abstract Poor wound healing in individuals with diabetes has long plagued clinicians, and immune cells play key roles in the inflammation, proliferation and remodeling that occur in wound healing. When skin integrity is damaged, immune cells migrate to the wound bed through the actions of chemokines and jointly restore tissue homeostasis and barrier function by exerting their respective biological functions. An imbalance of immune cells often leads to ineffective and disordered inflammatory responses. Due to the maladjusted microenvironment, the wound is unable to smoothly transition to the proliferation and remodeling stage, causing it to develop into a chronic refractory wound. However, chronic refractory wounds consistently lead to negative outcomes, such as long treatment cycles, high hospitalization rates, high medical costs, high disability rates, high mortality rates, and many adverse consequences. Therefore, strategies that promote the rational distribution and coordinated development of immune cells during wound healing are very important for the treatment of diabetic wounds (DW). Here, we explored the following aspects by performing a literature review: 1) the current situation of DW and an introduction to the biological functions of immune cells; 2) the role of immune cells in DW; and 3) existing (or undeveloped) therapies targeting immune cells to promote wound healing to provide new ideas for basic research, clinical treatment and nursing of DW.
Aberrant Dynamic Functional Connectivity of Posterior Cingulate Cortex Subregions in Major Depressive Disorder With Suicidal Ideation

Accumulating evidence indicates the presence of structural and functional abnormalities of the posterior cingulate cortex (PCC) in patients with major depressive disorder (MDD) with suicidal ideation (SI). Nevertheless, the subregional-level dynamic functional connectivity (dFC) of the PCC has not been investigated in MDD with SI. We therefore sought to investigate the presence of aberrant dFC variability in PCC subregions in MDD patients with SI. We analyzed resting-state functional magnetic resonance imaging (fMRI) data from 31 unmedicated MDD patients with SI (SI group), 56 unmedicated MDD patients without SI (NSI group), and 48 matched healthy control (HC) subjects. The sliding-window method was applied to characterize the whole-brain dFC of each PCC subregion [the ventral PCC (vPCC) and dorsal PCC (dPCC)]. In addition, we evaluated associations between clinical variables and the aberrant dFC variability of those brain regions showing significant between-group differences. Compared with HCS, the SI and the NSI groups exhibited higher dFC variability between the left dPCC and left fusiform gyrus and between the right vPCC and left inferior frontal gyrus (IFG). The SI group showed higher dFC variability between the left vPCC and left IFG than the NSI group. Furthermore, the dFC variability between the left vPCC and left IFG was positively correlated with Scale for Suicidal Ideation (SSI) score in patients with MDD (i.e., the SI and NSI groups). Our results indicate that aberrant dFC variability between the vPCC and IFG might provide a neural-network explanation for SI and may provide a potential target for future therapeutic interventions in MDD patients with SI.