Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating the three-network theory of creativity: Effects of music listening on resting state EEG

Research evidences the ability of music listening to transiently improve performance on creative cognition. However, the mechanism for cognitive improvements as a result of music listening is still contested. Research has asserted that three networks neatly map onto the well-known theory of blind variation and selective retention (BVRT); the default mode, cognitive control, and salience networks (SNs). This study investigates the activation in these networks after participants listen to music that has previously been shown to increase creative cognition. Using 128-channel high-density array, we measured resting state electroencephalography (EEG) in 26 participants before and after listening to the 2011 single “Can’t Hold Us. ” Findings demonstrate that activation is increased in the default mode, cognitive control, and SNs, as indicated by increases in spectral frequency power for whole-brain beta, parietal theta, and whole-brain gamma. Here, we find support for the idea that music might facilitate creative cognition by activating networks deemed important in the creative process, providing novel methodology for investigating network activation in a creative cognition framework using resting state EEG.
Choosing Who Chooses: Selection-Driven Targeting in Energy Rebate Programs

We develop an optimal policy assignment rule that systematically integrates two distinctive approaches commonly used in the literature—targeting by “observables” and targeting through “self-selection. " Our method identiﬁes who should be treated, untreated, and self-select into a treatment to maximize a policy’s social welfare gain. To generate data required to estimate optimal policy assignment, we designed a randomized controlled trial for a residential energy rebate program. We show that targeting that leverages information on both observables and self-selection outperforms conventional targeting for a standard utilitarian welfare function as well as welfare functions that balance the equity-efﬁciency trade-off. Fi-nally, we highlight that the LATE framework (Imbens and Angrist, 1994) can be used to uncover the mechanism behind our approach. We introduce new estimators, the LATEs for takers and non-takers , to show how our method identiﬁes whose self-selection is useful and harmful for the planner to maximize social welfare.
Heterogeneous nucleation and adatom detachment at one-dimensional growth of In on Si(100)-2×1

Growth of atomic indium chains - 1D islands - on the Si(100)-2x1 surface was observed by scanning tunneling microscopy (STM) at room temperature and simulated by means of a kinetic Monte Carlo method. Density of indium islands and island size distribution were obtained for various deposition rates and coverage. STM observation of growth during deposition of indium provided information on growth kinetics and relaxation of grown layers. Important role of C-type defects at adsorption of metal atoms was observed. Measured growth characteristics were simulated using a microscopic model with anisotropic surface diffusion and forbidden zones along the metal chains. An analysis of experimental and simulation data shows that detachment of indium adatoms from the chains substantially influences a growth scenario and results in monotonously decreasing chain length distribution function at low coverage. Diffusion barriers determined from the simulations correspond to almost isotropic diffusion of indium adatoms on the surface. The results are discussed with respect to data reported in earlier papers for other metals.
Effect of preventive periodontal health education on the oral hygiene of primary school children

Teachers are believed to be the key in any educational program so they could be targeted in order to enhance the effect of dental health education. A sample of eighty eight of first year primary school children aged 6 – 7 years old were randomly chosen and allocated into two group ,control and experimental (with 44 children in each group ). Teaching staff of experimental group were submitted to oral health education program that were conducted for the children in the experimental group only. The total sample were examined using plaque index PLI (silness & Loe) & gingival index GI (Loe & silness). The first examination carried out before the program conduction and the second examination done one month after. A highly significant improvement was recorded among the children in the experimental group after the program conduction. Results of this research support the positive role of the educational programs in the improvement of dental and periodontal health. Therefore, oral health education for school children is an essential activity for promoting, establishing and marinating optimal oral health and preventing oral diseases.
Prevalence of gastro-intestinal parasites in captive birds at Kamla Nehru Zoological Garden, Kankaria Zoo, Ahmedabad, Gujarat

987 Received 12 November 2001; Revised received 18 October 2002; Finally accepted 30 November 2002 Abstract A total of 138 group faecal samples collected cagewise of different wild birds from Kamla Nehru Zoological Garden, Kankaria Zoo, Ahmedabad were examined. Out of this 62 (44.93 %) were found positive for parasitic infection. Eggs of Ascaris and Capillaria species were observed in 25 (71.43%) and 13 (37.14%) samples respectively, while the oocyst of coccidia (Eimeria sp.) were observed in 53 (85.48%) samples. Ova of trematode 8 (12.90%) and cestode segment 3 (4.84%) were also observed.
HARMONIC FUNCTIONS ON THE BRANCHING GRAPH ASSOCIATED WITH THE INFINITE WREATH PRODUCT OF A COMPACT GROUP

A detailed study of the characters of S ∞ ( T ) , the wreath product of compact group T with the inﬁnite symmetric group S ∞ , is indispensable for harmonic analysis on this big group. In preceding works, we investigated limiting behavior of characters of theﬁnitewreathproduct S n ( T ) as n → ∞ anditsconnectionwithcharactersof S ∞ ( T ) . This paper takes a dual approach to these problems. We study harmonic functions on Y ( (cid:2) T ) , the branching graph of the inductive system of S n ( T ) ’s, and give a classiﬁcation of the minimal nonnegative harmonic functions on it. This immediately implies a classiﬁcation of the characters of S ∞ ( T ) , which is a logically independent proof of the one obtainedinearlierworks.Weobtainexplicitformulasforminimalnonnegativeharmonic functions on Y ( (cid:2) T ) and Martin integral expressions for harmonic functions.
The Linz Zoocode project. Fifth report of activities (2022).Nomenclatural availability. 4. Electronic publication

This fifth report of activities of the Linz Zoocode Committee is devoted to a detailed survey of the problems raised by the current Rules of the Code, published in 2012, regarding the nomenclatural availability of works published online and registered on the database Zoobank. It points to various deficiencies in these Rules and in the conception and functioning of Zoobank, which result in uncertainties regarding the availability of these works and of their various versions. It proposes new wordings for these Rules, as well as for the terminology used regarding electronic publications.
To What Degree Does Rapid Guessing Distort Aggregated Test Scores? A Meta-analytic Investigation

ABSTRACT The present meta-analysis sought to quantify the average degree of aggregated test score distortion due to rapid guessing (RG). Included studies group-administered a low-stakes cognitive assessment, identified RG via response times, and reported the rate of examinees engaging in RG, the percentage of RG responses observed, and/or the degree of score distortion in aggregated test scores due to RG. The final sample consisted of 25 studies and 39 independent samples comprised of 443,264 unique examinees. Results demonstrated that an average of 28.3% of examinees engaged in RG (21% were deemed to engage in RG on a nonnegligible number of items) and 6.89% of item responses were classified as rapid guesses. Across 100 effect sizes, RG was found to negatively distort aggregated test scores by an average of 0.13 standard deviations; however, this relationship was moderated by both test content area and filtering procedure.
Association of Diet, Body Mass Index, and Lifestyle on the Gastrointestinal Health Risk in a Sample of Adults

Gastrointestinal functional disorders are characterized by abnormalities in motility with visceral hypersensitivity, representing a global public health problem. We aimed to determine whether eating habits, lifestyle characteristics, and body mass index (BMI) are associated with gastrointestinal health risk. The Gastrointestinal Health (GIH) test of the World Gastroenterology Organization (WGO) and the Roma IV criteria were applied. We obtained information on food consumption habits and aerobic exercise, among other variables. Not exercising regularly, drinking water and eating vegetables less than recommended, having high body weight, and taking symptomatic medication were variables that explained 73% of the probabilities of not having good GIH (R2 = 0.734). According to Rome IV criteria, women had a 50% higher risk than men of having functional bowel disorder (RR 1.6, 95% CI: 1.04, 2.45). Among the men studied, eating few or no vegetables and drinking less than 1 L of water daily was more frequent; however, the women had significantly more intestinal symptoms. In addition, constipation was higher among women than men (p = 0.020). All of the above explains the prognostic value of eating habits and the importance of paying attention to body weight to reduce the risk of gastrointestinal disease.
Primary hyperoxaluria: The Baragwanath experience

Background. Primary hyperoxaluria (PH) is a rare autosomal recessive condition characterised by defects in the metabolism of glyoxylate which leads to excess oxalate production. It is an important disease to diagnose as it can progress to kidney failure (KF). Objective. To describe the characteristics, diagnosis and management of PH in South Africa and to identify any determinants of KF and death. Method. A retrospective study of all children younger than 16 years of age, diagnosed with PH at the Paediatric Renal Unit, Chris Hani Baragwanath Academic Hospital, from 1984 - 2017. Results. A total of 24 patients were identified, of which 20 records were available for complete analysis. The median age of presentation was 6.0 years. The common clinical presentations were urolithiasis (90%), KF (85%), nephrocalcinosis (75%), urinary tract infections (55%) and haematuria (30%). Nephrocalcinosis was better detected on abdominal radiograph compared with ultrasonography. Both nephrocalcinosis (p=0.009) and haematuria (p=0.018) were significantly associated with KF. Five patients had A112D genetic mutation in the AGXT. Fourteen received dialysis and four were transplanted. The mortality rate in this study was 58.3%. Conclusion. Clinicians should have a high index of suspicion for PH in patients presenting with haematuria, urolithiasis and KF. This study supports the measurement of urine oxalate levels and abdominal radiographs in screening for PH in children presenting in KF.
Relationship between Asymmetry Indices, Anthropometric Parameters, and Physical Fitness in Obese and Non-Obese High School Students

Impaired balance is associated with an increased risk of lower extremity injuries. The purpose of this study was to investigate the relationship between age, anthropometric measurement, and asymmetry index (AI) in an adolescent high school population. Twenty-six male students (15 ± 1.0 years) were randomly selected. Body composition, measurements of vertical jump height using a countermovement jump test (CMJ), and dynamic single stance balance using the Y-balance test (YBT), were collected over 4 weeks. Hierarchical multiple linear regression analyses were used as dimension reduction techniques in four different blocks to determine valid predictors for AIs. In the first regression analysis, controlling for age, body mass, height, and body mass index (BMI), the regression coefficient (B = 0.383, 95% confidence interval [CI] [0.088, 0.679], p < 0.05) associated with body fat indicated that with each additional unit of body fat, the YBT AI increased by 0.383 units. In the second regression analysis, controlling for age, body mass, and BMI, the regression coefficients associated with height (B = −1.692, 95% CI [−3.115, −0.269], p < 0.05] and body fat percentage (B = 0.529, 95% CI [0.075, 0.983], p < 0.05) indicated that with each additional unit of height or body fat percentage, the CMJ AI decreased by 1.692 units and increased by 0.529 units. Grouping participants based on body fat percentage had a significant effect on the AIs (p < 0.05) of the CMJ and YBT. The AI of the CMJ was 15% higher, and that of the YBT was 7% higher in non-obese students than obese students. These findings contribute to the knowledge of the local community and the emerging body of literature on motor skills and competence related to weight in this population.
Design of Montelukast Nanocrystalline Suspension for Parenteral Prolonged Delivery

Background Montelukast (MTK), a representative leukotriene receptor antagonist, is currently being investigated as a potential candidate for treating Alzheimer’s disease. For potent and effective dosing in elderly patients, a parenteral prolonged delivery system is favored, with improved medication adherence with reduced dosage frequency. Purpose This study aimed to design a nanocrystalline suspension (NS)-based MTK prolonged delivery system and evaluate its pharmacokinetics profile and local tolerability following subcutaneous administration. Methods To decelerate the dissolution rate, the amorphous MTK raw material was transformed into a crystalline state using a solvent-mediated transformation method and subsequently formulated into NS using a bead-milling technique. The MTK NSs were characterized by morphology, particle size, crystallinity, and in vitro dissolution profiles. The pharmacokinetic profile and local tolerability at the injection site following subcutaneous injection of MTK suspension were evaluated in rats. Results Microscopic and physical characterization revealed that the amorphous MTK powder was lucratively transformed into a crystalline form in acidic media (pH 4). MTK crystalline suspensions with different diameters (200 nm, 500 nm, and 3 μm) were uniformly prepared using bead-milling technology, employing polysorbate 80 as suspending agent. Prepared crystalline suspensions exhibited analogous crystallinity (melting point, 150°C) and size-dependent in vitro dissolution profiles. MTK NSs with particle sizes of 200 nm and 500 nm provided a protracted pharmacokinetic profile for up to 4 weeks in rats, with a higher maximum drug concentration in plasma than the 3 μm-sized injectable suspensions. Histopathological examination revealed that MTK NS caused chronic granulomatous inflammation at the injection site, which resolved after 4 weeks. Conclusion The MTK parenteral NS delivery system is expected to be a valuable tool for treating Alzheimer’s disease with extended dose intervals.
Genome-Wide Identification of P450 Genes in Chironomid Propsilocerus akamusi Reveals Candidate Genes Involved in Gut Microbiota-Mediated Detoxification of Chlorpyrifos

Simple Summary Propsilocerus akamusi is considered as a pollution-tolerant chironomid species in aquatic ecosystems. The capability of adapting to various contamination has been proved to rely on certain detoxifying enzymes, such as cytochrome P450 (P450), glutathione S-transferase (GST), etc. In the present study, 64 P450 genes were derived and characterized based on the available genome sequence. In addition, there is a potential role of gut microbial commensals in regulating local P450s when individuals have to deal with environmental stressors. Two screened P450s of gut tissue, PaCYP3998B1 and PaCYP3987D1, were remarkably decreased in chlorpyrifos-challenged subjects with deficient gut microbiota; this result suggested a possible function of gut microbial communities in enhancing host endogenous detoxification capability. Abstract Chironomids commonly dominate macroinvertebrate assemblages in aquatic habitats and these non-biting midges are known for their ability to tolerate contaminants. Studies regarding the interplay between gut microbiota and host detoxification ability is currently a point of interest. Cytochrome P450s (P450s) are critical metabolic enzymes in which a subset is involved in xenobiotic detoxification. In this study, we first conducted an integrated global investigation of P450s based on the whole genomic sequence of Propsilocerus akamusi and retrieved a series of 64 P450 genes which were further classified into 4 clans and 25 families on the basis of phylogenetic relationships. With assistance of RNA-Seq and RT-qPCR validation, the expression profile of screened PaP450s in guts was compared between chlorpyrifos-challenged larvae with deficient gut microbiota (GD) and those with a conventional gut community (CV). An increasing prevalence of chlorpyrifos from sublethal to lethal dosages induced a greater mortality rate of individuals coupled with remarkable downregulation of 14 P450s in GD larval guts when compared to CV ones. Moreover, it turned out that the decreased level of PaCYP3998B1 and PaCYP3987D1 might imply impaired host endogenous detoxification capability potentiated by gut dysbiosis, reflected by a remarkably severe mortality in GD larvae treated with lethal chlorpyrifos. Collectively, our study unveiled candidate P450 genes that might be mediated by gut symbionts in chlorpyrifos-challenged P. akamusi larvae, possibly facilitating further understanding of the detoxified mechanism that chironomids might employ to alleviate poisonousness.
Trastuzumab therapies in human epidermal growth factor receptor 2 cancer

Monoclonal antibodies therapy had shown critical importance in terms of personalized, disease-specific medicine. One example of monoclonal antibody is Trastuzumab, targeting on diseases such as breast cancer. Despite side effects like fever, chills, headache, infection, congestive heart failure, Trastuzumab is proved to be highly effective in experimental studies and clinical practice. Research has shown that through binding with human epidermal growth factor receptor 2, Trastuzumab is able to decrease its signaling pathways and therefore, inhibit cell proliferation and initiate apoptosis. The results of completed clinical trials and ongoing experimental studies, mainly focusing on the combination of trastuzumab and other treatments such as chemotherapy, have shown that compared with monotherapy or traditional conventional treatments such as surgery, radiotherapy, chemotherapy, etc., the combination of trastuzumab has a longer survival period and a lower recurrence rate. Some prime examples are discussed in this review to indicate recent trends of research on this topic. In addition, an in-depth analysis of possible directions of development of this technology is introduced.
Generic Rigidity of Complete Bipartite Graphs in Rd

Dans un article deja commente dans Topologie structurale, E.D. Bolkeret B. Roth ((Bolker 1980), (Whiteley 1979)) amorcaient une classification generique des graphes biparti-complets dans R2 et dans R3. Leur raisonnement etait base sur le calcul de la dimension de l’espace des autocontraintes (stress) pour une realisation d’un graphe biparti-complet dans un espace donne. La classification qu’ils etablissaient se limitait a R2 et A R3. Le texte qui suit se veut une generalisation de leurs resultats a des espaces de dimension superieure. Nous pourrons etablir la classification generique des structures construites sur des graphes biparti-complets en regard de leur comportement rigide dans un espace ambiant fixe de dimension superieure ou egale a 2.
Comparative transcriptome and metabolome analysis reveal key regulatory defense networks and genes involved in enhanced salt tolerance of Actinidia (kiwifruit)

Abstract The Actinidia (kiwifruit) is an emerging fruit plant that is severely affected by salt stress in northern China. Plants have evolved several signaling network mechanisms to cope with the detrimental effects of salt stress. To date, no reported work is available on metabolic and molecular mechanisms involved in kiwifruit salt tolerance. Therefore, the present study aims to decipher intricate adaptive responses of two contrasting salt tolerance kiwifruit species Actinidia valvata [ZMH (an important genotype), hereafter referred to as R] and Actinidia deliciosa [‘Hayward’ (an important green-fleshed cultivar), hereafter referred to as H] under 0.4% (w/w) salt stress for time courses of 0, 12, 24, and 72 hours (hereafter refered to as h) by combined transcriptome and metabolome analysis. Data revealed that kiwifruit displayed specific enrichment of differentially expressed genes (DEGs) under salt stress. Interestingly, roots of R plants showed a differential expression pattern for up-regulated genes. The KEGG pathway analysis revealed the enrichment of DEGs related to plant hormone signal transduction, glycine metabolism, serine and threonine metabolism, glutathione metabolism, and pyruvate metabolism in the roots of R under salt stress. The WGCNA resulted in the identification of five candidate genes related to glycine betaine (GB), pyruvate, total soluble sugars (TSS), and glutathione biosynthesis in kiwifruit. An integrated study of transcriptome and metabolome identified several genes encoding metabolites involved in pyruvate metabolism. Furthermore, several genes encoding transcription factors were mainly induced in R under salt stress. Functional validation results for overexpression of a candidate gene betaine aldehyde dehydrogenase (AvBADH, R_transcript_80484) from R showed significantly improved salt tolerance in Arabidopsis thaliana (hereafter referred to as At) and Actinidia chinensis [‘Hongyang’ (an important red-fleshed cultivar), hereafter referred to as Ac] transgenic plants than in WT plants. All in all, salt stress tolerance in kiwifruit roots is an intricate regulatory mechanism that consists of several genes encoding specific metabolites.
Cysteine Regulates Oxidative Stress and Glutathione-Related Antioxidative Capacity before and after Colorectal Tumor Resection

Cysteine might scavenge free radicals and is a limiting substrate for the cellular synthesis of glutathione (GSH). We investigated the association of cysteine with oxidative stress and GSH-related antioxidant capacity in colorectal cancer (CRC) patients. Plasma samples were drawn from 66 patients 1 day before (pre-resection) and 4 weeks after resection (post-resection). Tumor and adjacent normal tissues were collected. We measured levels of plasma and tissue cysteine, homocysteine, oxidative stress indicators (malondialdehyde, MDA; advanced oxidation protein products, AOPP), GSH, and antioxidant enzyme activities. After tumor resection, patients had significantly higher levels of plasma cysteine, homocysteine, MDA, AOPP, and GSH-related antioxidant enzyme activities when compared with pre-resection. Levels of cysteine, homocysteine, AOPP and all antioxidant capacity indicators in tumor tissue were significantly higher than those levels in the adjacent normal tissue. Plasma cysteine levels measured at pre-resection were positively associated with MDA levels in the tumor and in the adjacent normal tissues. Cysteine levels in tumor and adjacent normal tissues were significantly associated with tissue levels of homocysteine, almost as indicators of oxidative stress and antioxidant capacities. Cysteine in the circulation was likely utilized to mediate GSH-related antioxidant capacity and further cope with increased oxidative stress in tumor and adjacent normal tissues.