Miracle-dz/UniFAR-FTUs huggingface dataset:
Salivary androgens in adolescence and their value as a marker of puberty: results from the SCAMP cohort

Context Salivary androgens represent non-invasive biomarkers of puberty that may have utility in clinical and population studies. Objective To understand normal age-related variation in salivary sex steroids and demonstrate their correlation to pubertal development in young adolescents. Design, setting and participants School-based cohort study of 1495 adolescents at two time points for collecting saliva samples approximately 2 years apart. Outcome measures The saliva samples were analyzed for five androgens (testosterone, androstenedione (A4), 17-hydroxyprogesterone, 11-ketotestosterone and 11β-hydroxyandrostenedione) using liquid chromatography-mass spectrometry; in addition, salivary dehydroepiandrosterone (DHEA) and oestradiol (OE2) were analysed by ELISA. The pubertal staging was self-reported using the Pubertal Development Scale (PDS). Results In 1236 saliva samples from 903 boys aged between 11 and 16 years, salivary androgens except DHEA exhibited an increasing trend with an advancing age (ANOVA, P < 0.001), with salivary testosterone and A4 concentration showing the strongest correlation (r = 0.55, P < 0.001 and r = 0.48, P < 0.001, respectively). In a subgroup analysis of 155 and 63 saliva samples in boys and girls, respectively, morning salivary testosterone concentrations showed the highest correlation with composite PDS scores and voice-breaking category from PDS self-report in boys (r = 0.75, r = 0.67, respectively). In girls, salivary DHEA and OE2 had negligible correlations with age or composite PDS scores. Conclusion In boys aged 11–16 years, an increase in salivary testosterone and A4 is associated with self-reported pubertal progress and represents valid non-invasive biomarkers of puberty in boys.
Instantaneous paleomagnetic record from the Miocene Kozagawa Dike of the Kumano Acidic Rocks, Kii Peninsula, Southwest Japan: cautionary note on tectonic interpretation

We have conducted a paleomagnetic investigation of the Kozagawa Dike, which is part of the Kumano Acidic Rocks that are the product of a Middle Miocene volcano–plutonic complex cropping out on the Kii Peninsula of Southwest Japan. The granite porphyry facies of the dike yields stable remanent magnetization components. Precisely determined site‐mean directions of characteristic components, as revealed by principal component analysis of stepwise alternating‐field and thermal demagnetization results, form a tight cluster. The overall mean direction exhibits an approximately 40° clockwise declination shift from the south and a steep negative inclination (D = 217.3°, I = −59.8°, α95 = 2.8°; 10 sites). Rock magnetic analyses suggest that magnetite is the main stable component carrier. The overall mean direction is interpreted to be a geologically instantaneous record of the paleomagnetic field that was acquired in a relatively short time interval relative to paleomagnetic secular variations. The mean direction in geographic (in situ) coordinates obtained for the Kozagawa Dike is distinct from previously published data for laccolithic granite porphyry intrusions of the Kumano Acidic Rocks. This difference may result from a time lag during acquisition of remanent magnetization by the different units of the Kumano Acidic Rocks. The southwest and up paleomagnetic direction has previously been interpreted as representing clockwise rotation of Southwest Japan associated with back‐arc opening of the Japan Sea. However, we contend that these directions actually reflect the transient capture of an extraordinary paleomagnetic field at ca 14.3 Ma, such as a transitional or excursional state, and are not of tectonic origin.
Insights into the history and tendency of liver transplantation for liver cancer: a bibliometric-based visual analysis

Research on liver transplantation (LT) for liver cancer has gained increasing attention. This paper has comprehensively described the current status, hotspots and trends in this field. A total of 2991 relevant articles from 1 January 1963 to 28 February 2023 were obtained from the Web of Science Core Collection. VOSviewer and CiteSpace software were utilized as bibliometric tools to analyze and visualize knowledge mapping. Between 1963 and 2023, the number of papers in the area of LT for liver cancer increased continuously. A total of 70 countries/regions, 2303 institutions and 14 840 researchers have published research articles, with the United States and China being the two most productive countries. Our bibliometric-based visual analysis revealed the expansion of LT indications for liver cancer and the prevention/treatment of cancer recurrence as ongoing research hotspots over the past decades. Meanwhile, emerging studies also focus on downstaging/bridging treatments before LT and the long-term survival of LT recipient, in particular the precise application of immunosuppressants.
High-Dose Methotrexate as CNS Prophylaxis in High-Risk Aggressive B-Cell Lymphoma

PURPOSE CNS progression or relapse is an uncommon but devastating complication of aggressive B-cell lymphoma. There is no consensus regarding the optimal approach to CNS prophylaxis. This study was designed to determine whether high-dose methotrexate (HD-MTX) is effective at preventing CNS progression in patients at high risk of this complication. PATIENTS AND METHODS Patients age 18-80 years with aggressive B-cell lymphoma and high risk of CNS progression, treated with curative-intent anti–CD20-based chemoimmunotherapy, were included in this international, retrospective, observational study. Cause-specific hazard ratios (HRs) and cumulative risks of CNS progression were calculated according to use of HD-MTX, with time to CNS progression calculated from diagnosis for all patients (all-pts) and from completion of frontline systemic lymphoma induction therapy, for patients in complete response at completion of chemoimmunotherapy (CR-pts). RESULTS Two thousand four hundred eighteen all-pts (HD-MTX; n = 425) and 1,616 CR-pts (HD-MTX; n = 356) were included. CNS International Prognostic Index was 4-6 in 83.4% all-pts. Patients treated with HD-MTX had a lower risk of CNS progression (adjusted HR, 0.59 [95% CI, 0.38 to 0.90]; P = .014), but significance was not retained when confined to CR-pts (adjusted HR, 0.74 [95% CI, 0.42 to 1.30]; P = .29), with 5-year adjusted risk difference of 1.6% (95% CI, –1.5 to 4.4; all-pts) and 1.4% (95% CI, –1.5 to 4.1; CR-pts). Subgroups were underpowered to draw definitive conclusions regarding the efficacy of HD-MTX in individual high-risk clinical scenarios; however, there was no clear reduction in CNS progression risk with HD-MTX in any high-risk subgroup. CONCLUSION In this large study, high-risk patients receiving HD-MTX had a 7.2% 2-year risk of CNS progression, consistent with the progression risk in previously reported high-risk cohorts. Use of HD-MTX was not associated with a clinically meaningful reduction in risk of CNS progression. Systemic methotrexate did not reduce CNS progression in high-risk aggressive B-cell lymphoma (n = 2,418).
North Sea Quaternary morphology from seismic and magnetic data: indications for gas hydrates during glaciation?

Buried circular depressions and channels in Quaternary strata have been investigated by 3D seismic data and, less commonly, by high-resolution aeromagnetic data. Sub-glacial melt-water drainage channels of various dimensions are the most distinct morphological features. In the same strata, numerous crater-shaped depressions were found, some coinciding with the initiation of channels. The diameter ranges from 500 m to 3000 m and the depth from 20 to 300 m – appreciably larger than common pockmarks. It is argued here that the craters were generated by gas expulsion from melted gas hydrates, combined with melt-water expulsion and erosion. This is supported by: (1) a similarity with published seafloor craters that originate from melted gas hydrates; (2) appropriate physical conditions for the formation and melting of gas hydrates during glacial and interglacial periods; (3) correlation with shallow gas occurrences and seismic gas indications. An increased number of craters occurs above a major fault and some Tertiary hydrocarbon discoveries, which may indicate thermogenic gas. At such locations, an increase in high-frequency magnetic anomalies can be explained by deposition of sediments with contrasting magnetic susceptibilities. This is an alternative explanation for the occasionally increased shallow magnetic anomalies above hydrocarbon fields, otherwise attributed to secondary changes in the magnetic mineralogy.
Can we define an asymptotic value for the ice active surface site density for heterogeneous ice nucleation?

The immersion freezing behavior of droplets containing size‐segregated, monodisperse feldspar particles was investigated. For all particle sizes investigated, a leveling off of the frozen droplet fraction was observed reaching a plateau within the heterogeneous freezing temperature regime (T >− 38°C). The frozen fraction in the plateau region was proportional to the particle surface area. Based on these findings, an asymptotic value for ice active surface site density ns, which we named ns⋆ , could be determined for the investigated feldspar sample. The comparison of these results with those of other studies not only elucidates the general feasibility of determining such an asymptotic value but also shows that the value of ns⋆ strongly depends on the method of the particle surface area determination. However, such an asymptotic value might be an important input parameter for atmospheric modeling applications. At least it shows that care should be taken when ns is extrapolated to lower or higher temperature.
Kinetics of chemical weathering in b horizon spodosol fraction

Studies on a B horizon soil from Maine have been conducted to determine the weathering rate dependence on hydrogen ion concentration in soil solution. Effects of soil concentration and solution chemistry on chemical weathering rate were also investigated. Studies were conducted using a laboratory pH-stat semicontinuous reactor at pH 2.7 and 3.5 for two concentrations of B horizon soil. Homogenized B horizon soil in the size range 63–125 μm was washed in deionized water and acetone and used without further treatment. Results obtained from titrations of 10, 30, and 100 g/L of soil at a constant pH of 2.7 suggest that the weathering rate, expressed in μeq H+/hr/g soil, does not depend on the soil concentration in the pH-stat reactor. In order to test the effect of solute concentration on weathering rate, experiments were performed at two different concentrations of accumulated solutes. Weathering rates were the same at the two solute concentrations, indicating that significant back reactions were not likely occurring. The weathering rate at pH 2.7 was estimated in the range 0.53–0.93 μeq H+/hr/g soil, at pH 3.0 as 0.52 μeq H+/hr/g soil, at pH 3.5 as 0.36 μeq H+/hr/g soil, and at pH 4.0 as 0.04 μeq H+/hr/g soil. Assuming a weathering rate proportional to {H+}m, the fractional order m was determined to be approximately 0.8. Results were consistent with a surface-reaction-controlled dissolution mechanism.
Association of Parity and Previous Birth Outcome With Brachial Plexus Birth Injury Risk

Parity, previous shoulder dystocia, and previously delivering a neonate with a brachial plexus injury are associated with future brachial plexus birth injury risk. Cesarean delivery partially mitigates this risk. OBJECTIVE: To evaluate the association of maternal delivery history with a brachial plexus birth injury risk in subsequent deliveries and to estimate the effect of subsequent delivery method on brachial plexus birth injury risk. METHODS: We conducted a retrospective cohort study of all live-birth deliveries occurring in California-licensed hospitals from 1996 to 2012. The primary outcome was recurrent brachial plexus birth injury in a subsequent pregnancy. The exposure was delivery history (parity, shoulder dystocia in a previous delivery, or previously delivering a neonate with brachial plexus birth injury). Multiple logistic regression was used to model adjusted associations of delivery history with brachial plexus birth injury in a subsequent pregnancy. The adjusted risk and adjusted risk difference for brachial plexus birth injury between vaginal and cesarean deliveries in subsequent pregnancies were determined, stratified by delivery history, and the number of cesarean deliveries needed to prevent one brachial plexus birth injury was determined. RESULTS: Of 6,286,324 neonates delivered by 4,104,825 individuals, 7,762 (0.12%) were diagnosed with a brachial plexus birth injury. Higher parity was associated with a 5.7% decrease in brachial plexus birth injury risk with each subsequent delivery (adjusted odds ratio [aOR] 0.94, 95% CI 0.92–0.97). Shoulder dystocia or brachial plexus birth injury in a previous delivery was associated with fivefold (0.58% vs 0.11%, aOR 5.39, 95% CI 4.10–7.08) and 17-fold (1.58% vs 0.11%, aOR 17.22, 95% CI 13.31–22.27) increases in brachial plexus birth injury risk, respectively. Among individuals with a history of delivering a neonate with a brachial plexus birth injury, cesarean delivery was associated with a 73.0% decrease in brachial plexus birth injury risk (0.60% vs 2.21%, aOR 0.27, 95% CI 0.13–0.55) compared with an 87.9% decrease in brachial plexus birth injury risk (0.02% vs 0.15%, aOR 0.12, 95% CI 0.10–0.15) in individuals without this history. Among individuals with a history of brachial plexus birth injury, 48.1 cesarean deliveries are needed to prevent one brachial plexus birth injury. CONCLUSIONS: Parity, previous shoulder dystocia, and previously delivering a neonate with brachial plexus birth injury are associated with future brachial plexus birth injury risk. These factors are identifiable prenatally and can inform discussions with pregnant individuals regarding brachial plexus birth injury risk and planned mode of delivery.
Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice

Background and Aims Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the impact by which liver-specific CPT1a deletion impacts hepatic lipid metabolism. Approach and Results Six-to-eight-week old male and female liver-specific knockout (LKO) and littermate controls were placed on a low-fat or high-fat diet (HFD; 60% kcal fat) for 15 weeks. Mice were necropsied after a 16 hour fast, and tissues were collected for lipidomics, matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI), kinome analysis, RNA-sequencing, and protein expression by immunoblotting. Female LKO mice had increased serum alanine aminotransferase (ALT) levels which were associated with greater deposition of hepatic lipids, while male mice were not affected by CPT1a deletion relative to male control mice. Mice with CPT1a deletion had reductions in DHA-containing phospholipids at the expense of monounsaturated fatty acids (MUFA)-containing phospholipids in both whole liver and at the level of the lipid droplet (LD). Male and female LKO mice increased RNA levels of genes involved in LD lipolysis (Plin2, Cidec, G0S2) and in polyunsaturated fatty acid (PUFA) metabolism (Elovl5, Fads1, Elovl2), while only female LKO mice increased genes involved in inflammation (Ly6d, Mmp12, Cxcl2). Kinase profiling showed decreased protein kinase A (PKA) activity, which coincided with increased PLIN2, PLIN5, and G0S2 protein levels and decreased triglyceride hydrolysis in LKO mice. Conclusions Liver-specific deletion of CPT1a promotes sexually dimorphic steatotic liver disease (SLD) in mice, and here we have identified new mechanisms by which females are protected from HFD-induced liver injury. Graphical Summary
Comparison of supraclavicular brachiocephalic and femoral vein approaches for tunneled dialysis catheter placement in patients with thrombosed internal jugular veins

There is still debate on the best access route in case of bilateral internal jugular vein thrombosis. We aimed to compare the safety, effectiveness, and outcomes of tunneled dialysis catheter placement via supraclavicular brachiocephalic and femoral vein approaches in patients with bilateral internal jugular vein thrombosis.
Shared Loanword Recognition in German–English Bilinguals: The Role of Metrical Phonology

Abstract The role of phonology in bilingual word recognition has focused on a phonemic level especially in the recognition of cognates. In this study, we examined differences in metrical structure to test whether first language (L1) metrical structure influences the processing of second language (L2) words. For that, we used words of Romance origin (e.g., reptile, signal), which both German and English have borrowed extensively. However, the existing metrical patterns are not identical nor are the borrowed vocabularies the same. Rather, those identical words differ systematically in their foot structure. We conducted a cross-modal form fragment priming EEG experiment (auditory–visual) with German native speakers who were highly proficient in English. Both behavioral and ERP results showed an effect of the native phonology and the loan status, that is, whether the loan exists only in the speaker's L2 or is shared across languages. Priming effects (RTs) were largest for nonshared loanwords indicating some interference from German (L1). This was also evident in a reduced N400 but only if the metrical structure aligned with German patterns for Germanic words, that is, two light syllables as in pigeon. If the words exist in both languages, metrical structure also mattered shown by the modulation of different ERP components across conditions. Overall, our study indicates that metrical phonology plays a role in loanword processing. Our data show that the more similar a word is in terms of its metrical phonology across L1 and L2, the more effortful the processing of a word within a priming paradigm indicating interference from the L1 phonology.
InterlACE Sound Coding for Unilateral and Bilateral Cochlear Implants

Objective: Cochlear implant signal processing strategies define the rules of how acoustic signals are converted into electrical stimulation patterns. Technological and anatomical limitations, however, impose constraints on the signal transmission and the accurate excitation of the auditory nerve. Acoustic signals are degraded throughout cochlear implant processing, and electrical signal interactions at the electrode-neuron interface constrain spectral and temporal precision. In this work, we propose a novel InterlACE signal processing strategy to counteract the occurring limitations. Methods: By replacing the maxima selection of the Advanced Combination Encoder strategy with a method that defines spatially and temporally alternating channels, InterlACE can compensate for discarded signal content of the conventional processing. The strategy can be extended bilaterally by introducing synchronized timing and channel selection. InterlACE was explored unilaterally and bilaterally by assessing speech intelligibility and spectral resolution. Five experienced bilaterally implanted cochlear implant recipients participated in the Oldenburg Sentence Recognition Test in background noise and the spectral ripple discrimination task. Results: The introduced alternating channel selection methodology shows promising outcomes for speech intelligibility but could not indicate better spectral ripple discrimination. Conclusion: InterlACE processing positively affects speech intelligibility, increases available unilateral and bilateral signal content, and may potentially counteract signal interactions at the electrode-neuron interface. Significance: This work shows how cochlear implant channel selection can be modified and extended bilaterally. The clinical impact of the modifications needs to be explored with a larger sample size.
Prior Hospitalization, Severe Maternal Morbidity, and Pregnancy-Associated Deaths in Massachusetts From 2002 to 2019

Prior hospitalizations, severe maternal morbidity, and opioid use were strongly associated with death during pregnancy or within the first year postpartum, even after the exclusion of pregnancy-related deaths. OBJECTIVE: To examine demographic and clinical precursors to pregnancy-associated deaths overall and when pregnancy-related deaths are excluded. METHODS: We conducted a retrospective cohort study based on a Massachusetts population–based data system linking data from live birth and fetal death certificates to corresponding delivery hospital discharge records and a birthing individual's nonbirth hospital contacts and associated death records. Exposures included maternal demographics, severe maternal morbidity (without transfusion), hospitalizations in the 3 years before pregnancy, comorbidities during pregnancy, and opioid use. In cases of postpartum deaths, hospitalization between delivery and death was examined. The primary outcome measure was pregnancy-associated death, defined as death during pregnancy or up to 1 year postpartum. RESULTS: There were 1,291,626 deliveries between 2002 and 2019, of which 384 were linked to pregnancy-associated deaths. Pregnancy-associated but not pregnancy-related deaths (per 100,000 deliveries) were highest for birthing people with opioid use before pregnancy (498.3), severe maternal morbidity (387.3), a comorbidity (106.3), or a prior hospitalization (88.9). In multivariable analysis, the adjusted risk ratios associated with severe maternal morbidity (9.37, 95% CI, 6.14–14.31) and opioid use (6.49, 95%, CI, 3.71–11.35) were highest. Individuals with pregnancy-associated deaths were also more likely to have been hospitalized before or during pregnancy (2.30, 95% CI, 1.62–3.26). Among postpartum deaths, more than two-thirds (69.9%) of birthing people had a hospital contact after delivery and before their death. CONCLUSION: Severe maternal morbidity and opioid use disorder were precursors to pregnancy-associated deaths. Individuals with pregnancy-associated but not pregnancy-related deaths experienced a history of hospital contacts during and after pregnancy before death.
Tomographic inversions for mantle P wave velocity structure based on the minimization of l 2 and l 1 norms of International Seismological Centre Travel Time Residuals

We use International Seismological Centre (ISC) P arrival data (1964–1987) and iterative algorithms which minimize the l1 and l2 residual norms to solve simultaneously for three-dimensional P velocity variations in Earth's mantle, source mislocations, and station corrections. We find that the maximum velocity perturbations produced by the l1 minimization (approximately ±4% in our final model) are relatively insensitive to smoothing and damping constraints. Therefore, using an l1 norm criterion allows us to keep the bias introduced to the inversion to a minimum. Among the well-resolved features contained in both the l1 and the l2 velocity models are a fast anomaly in the lower mantle beneath the Tonga-New Hebrides subduction zone to a depth of 1670 km and another fast anomaly beneath the Japanese island arc and eastern Asia. Continuity between these anomalies and shallower fast anomalies is not clear. A fast anomaly extending from 670 km to 2070 km depth appears beneath eastern North America, the Caribbean, and north central South America. A broad, fast anomaly appears beneath eastern Asia just above the core-mantle boundary as well as several slow anomalies under the Pacific basin of comparable size. Both models contain a circum-Pacific ring of 2% lower velocities in the depth range 0–200 km, associated with back arc basins. High velocities (over 2%) associated with the continental shields tend to disappear below 400 km, though a significant region of high velocity remains beneath the Siberian platform in the 400 to 670 km depth interval.