Miracle-dz/UniFAR-FTUs huggingface dataset:
Mental Health Consequences of the COVID-19 Pandemic Long-Term Exposure in Italian Dermatologists

The present study aimed at assessing the consequences of prolonged exposure to COVID-19 distress on mental health in non-frontline health care workers. For this purpose, we have conducted a survey on 425 Italian dermatologists, in the period February–March 2021. The psychopathological symptoms, depression, anxiety, post-traumatic stress symptoms (PTSD), as well as resilience, have been evaluated. The main factors that influence the physician’s psychological health have been also investigated. Our study showed that the physicians older than 40 years, as well as those who lived this period in company, reported more personal resources, better managing the distress. Resilience, COVID-19 beliefs, COVID-19 working difficulties, and age were the common predictors of the severe psychopathological symptoms. An interesting result is that the lower level of resilience was the most powerful predictor of a more severe depression, as well as of a higher severity of generalized anxiety disorder, but not of COVID-19 PTSD. The fear of COVID-19 was the most powerful predictor of COVID-19 PTSD. Home conditions and previous SARS-CoV2 infection constituted significant predictors of severe depressive symptoms, but not of anxiety and COVID-19 PTSD. These results are useful in a better understanding of protective and risk factors involved in COVID-19 long-term distress exposure.
Grade reporting and student performance

ABSTRACT Academic feedback has a direct impact on students' effort decisions and academic performance. However, the grades that are reported to students are often based on institutional or instructor preferences, with entities adopting a discrete or fine grading scale. In this study, we utilize a field experiment to assess how a Letter (LGS) or Numerical Grading System (NGS) impacts students' academic performance. The results indicate that the grading system utilized has no overall impact on students' performance. However, we do observe that there is a heterogeneous impact of the grading system across gender and students' pre-treatment performance.
Individual‐, household‐, and community‐level factors associated with pregnant married women's discriminatory attitude towards people living with HIV in sub‐Saharan Africa: A multicountry cross‐sectional study

Discriminatory attitude towards people living with human immunodeficiency virus (HIV) remains a major problem in the prevention and treatment of HIV in sub‐Sahara Africa (SSA). Understanding the multiple factors linked to discriminatory attitude towards people living with HIV/AIDS (PLWHA) in SSA is necessary for developing appropriate interventions. This study aimed at investigating the individual, household, and community‐level factors associated with pregnant married women's discriminatory attitude towards people living with HIV/AIDS.
Adenovirus-α-defensin complexes induce NLRP3-associated maturation of human phagocytes via TLR4 engagement

Intramuscular delivery of human adenovirus (HAdV)-based vaccines leads to rapid recruitment of neutrophils, which then release antimicrobial peptides/proteins (AMPs). How these AMPs influence vaccine efficacy over the subsequent 24 hr is poorly understood. In this study, we asked if human neutrophil protein 1 (HNP-1), an α-defensin that influences the direct and indirect innate immune responses to a range of pathogens, impacts the innate response of human phagocytes to three HAdV species/types (HAdV-C5, -D26, -B35). We show that HNP-1 binds to the capsids, redirects HAdV-C5, -D26, -B35 to Toll-like receptor 4 (TLR4), which leads to internalization, an NLRP3-mediated inflammasome response, and IL-1β release. Surprisingly, IL-1β release was not associated with notable disruption of plasma membrane integrity. These data further our understanding of HAdV innate immunogenicity and may provide pathways to extend HAdV-based vaccines efficacy.
Fluorite Mineralization Related to Carbonatitic Magmatism in the Western Transbaikalia: Insights from Fluid Inclusions and Trace Element Composition

Fluorite mineralization associated with different types of magmatism is common in the Western Transbaikalia. This study deals with Arshan, Yuzhnoe, and Ulan-Ude fluorite occurrences, which are the most significant examples of carbonatite-related fluorite mineralization in the region. The present paper focused on new fluorite geochemistry and fluid inclusion data, is aimed at revealing conditions of the fluorite mineralization formation, highlighting its genetic relationship with magmatism, compared to other deposits of this type. All the three locations belong to the Late Mesozoic Central Asian carbonatite province. Fluorites here are characterized by high rare earth elements (REE), Sr, and elevated La/Yb values. Fluid inclusions data imply that the formation of fluorite mineralization is a long process extending from late magmatic to the hydrothermal stage. Early fluorite crystallized from sulfate-carbonate orthomagmatic fluids at temperatures up to 500 °C. True hydrothermal fluorite was formed from the same fluids that were probably mixed with meteoric waters, which caused the temperature to drop to below 420 °C and led to an increase in the chloride component. The REE compositions of fluorite from the studied locations are similar to compositions of REE-rich fluorites from carbonatite-related deposits around the world.
Dilemmas of public goods provisioning: institutional mechanisms for agricultural drainage management in Ohio, USA

Institutions are critical for collective action around several environmental policy issues. A seldom-studied issue, agricultural drainage, provides a rich setting to examine how institutional mechanisms interact with two variables linked to collective action: group size and heterogeneity. In this study, we examine institutions for establishing and maintaining agricultural drainage systems in the Western Lake Erie Basin region of Ohio. Specifically, we examine whether and how drainage management institutions interact with two variables, group size and heterogeneity in benefits and costs, for solving the public-good dilemmas of agricultural drainage. Data for this study come from a comparative case study design, using semi-structured in-depth interviews, and a landowner survey. Results suggest that the Olson effect for group size is mediated by institution type, and heterogeneity in benefits and costs is mediated by fairness perceptions, in affecting incentives for collective action. We discuss our findings in light of theories of collective action.
Knowledge and Utilization of Iodized Salt and Associated Factors among Households of Fitche Town, Central Ethiopia, 2020: A Community based Cross-Sectional Study

Adequate knowledge and proper utilization of iodized salt in the household is a significant factor in the prevention of iodine deficiency disorders. This study was aimed at assessing knowledge and utilization of iodized salt and associated factors among the Fitche town community. A total of 470 individuals in the household were participated. About 58.6% of the respondents had good knowledge of iodized salt use and 52.6% use adequately iodized salt. Having higher monthly income [adjusted odds ratio (AOR)=2.97, 95%confidence interval (CI):1.05-8.42], having family health insurance [AOR=2.57, 95%CI:1.15-5.74] and being aware of iodine deficiency consequences [AOR=1.88, 95%CI:1.03-3.40)] were significantly associated with proper utilization of iodized salt. Besides, acquiring health advice on iodized salt [AOR=2.20, 95%CI:1.10-4.40] and educational status [AOR=0.14, 95%CI:0.03-0.56] were shown significant association with the knowledge of respondents on iodized salt use. Even though knowledge of iodized salt use in the study area is higher as compared to other findings, the coverage of proper iodized salt utilization is less than the world health organization recommendation of iodized salt use in households. Therefore, promoting the knowledge and utilization of iodized salt should be strengthened. Additionally, routine testing and monitoring for iodine levels in salt sold in the markets and used by households have enormous benefits.
DNA Methylation and Schizophrenia: Current Literature and Future Perspective

Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea, identity, and emotions. It has no central pathophysiological mechanism and precise diagnostic markers. Despite its high heritability, there are also environmental factors implicated in the development of schizophrenia. Epigenetic factors are thought to mediate the effects of environmental factors in the development of the disorder. Epigenetic modifications like DNA methylation are a risk factor for schizophrenia. Targeted gene approach studies attempted to find candidate gene methylation, but the results are contradictory. Genome-wide methylation studies are insufficient in literature and the available data do not cover different populations like the African populations. The current genome-wide studies have limitations related to the sample and methods used. Studies are required to control for these limitations. Integration of DNA methylation, gene expression, and their effects are important in the understanding of the development of schizophrenia and search for biomarkers. There are currently no precise and functional biomarkers for the disorder. Several epigenetic markers have been reported to be common in functional and peripheral tissue. This makes the peripheral tissue epigenetic changes a surrogate of functional tissue, suggesting common epigenetic alteration can be used as biomarkers of schizophrenia in peripheral tissue.
Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study

Background: Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are scarce. Objective: To assess the safety and efficacy of CA for atrial arrhythmias in patients with ARVC. Methods: In this international collaborative effort, all patients with a definite diagnosis of ARVC undergoing CA for atrial fibrillation (AF), focal atrial tachycardia (AT), or cavotricuspid isthmus (CTI)-dependent atrial flutter (AFl) were extracted from twelve ARVC registries. Demographic, periprocedural, and long-term arrhythmic outcome data were collected. Results: Thirty-seven patients were enrolled in the study (age 50.2 ± 16.6 years, male 84%, CHA2DS2VASc 1 (1,2), HAS-BLED 0 (0–2)). The arrhythmia leading to CA was AF in 23 (62%), focal left AT in 5 (14%), and CTI-dependent AFl in 9 (24%). Acute procedural success was achieved in all procedures but one (n = 1 focal left AT; 97% acute success). The median follow-up period was 27 (13–67) months, and 96%, 74%, and 61% of patients undergoing AF ablation were free from any atrial arrhythmia recurrence after a single procedure at 6 months, 12 months, and last follow-up, respectively. After focal AT ablation, freedom from atrial arrhythmia recurrence was 80%, 80%, and 60% at 6 months, 12 months, and last follow-up, respectively. All patients undergoing CTI ablation were free from atrial arrhythmia recurrences at 6 months, with 89% single-procedural arrhythmic freedom at last follow-up. One major complication (2.7%; PV stenosis requiring PV stenting) occurred. Conclusions: CA is safe and effective in managing atrial arrhythmias in patients with ARVC, with success rates comparable to the general population.
Functionally Heterogenous Macrophage Subsets in the Pathogenesis of Giant Cell Arteritis: Novel Targets for Disease Monitoring and Treatment

Giant cell arteritis (GCA) is a granulomatous large-vessel vasculitis that affects adults above 50 years of age. In GCA, circulating monocytes are recruited to the inflamed arteries. With cues from the vascular microenvironment, they differentiate into macrophages and play important roles in the pathogenesis of GCA via pro-inflammatory cytokine production and vascular remodeling. However, a deeper understanding of macrophage heterogeneity in GCA pathogenesis is needed to assist the development of novel diagnostic tools and targeted therapies. Here, we review the current knowledge on macrophage heterogeneity and diverse functions of macrophage subsets in the pathogenesis of GCA. We next discuss the possibility to exploit their heterogeneity as a source of novel biomarkers and as targets for nuclear imaging. Finally, we discuss novel macrophage-targeted therapies and future directions for targeting these cells in GCA.
Development and Progression of Coronary Artery Calci fi cation in Long-Term Smokers

tery calcium (CAC) among participants with CAC 1⁄4 0 at b Frequency of CAC progression in ex-smokers (white), con of incident CAC (C) and CAC progression (D). Based on ogression was adjusted for baseline CAC scores in CAC r interval. the effects of continued smoking on the development and progression of subclinical coronary artery calcification (CAC) over time. A total of 1,265 current or previous smokers 50 to 70 years old with at least 20 pack-years and without coronary artery disease
An Investigation into the Effect of Emissions from Industrial Complexes on Air Quality in the Ulsan Metropolitan City Utilizing Trace Components in PM2.5

This study investigates the impact of industrial complexes on the air quality in the Ulsan Metropolitan City, Korea, by analyzing the concentration of trace substances. Importantly, this study performs segmentation and analysis of the components of particulate matter for tracking emission sources. Concentrations of particulate matter with aerodynamic diameters ≤10 and ≤2.5 µm (PM10 and PM2.5, respectively) and 19 substances comprising PM2.5 (such as ions, carbon, and nine elements) were measured hourly during the year 2017 in the southeastern intensive air quality monitoring station of the National Institute of Environmental Research, Korea. This study identified and investigated the time periods during which the vanadium content in PM2.5 was higher than the annual mean (1.026 ng/µg) through selection cases (SCs). The annual mean concentrations of PM2.5 and PM10 were 18.50 and 32.35 µg/m3, respectively, and were higher (i.e., 26.54 and 45.84 µg/m3, respectively) in SCs. Notably, the concentrations were high even when the main wind direction of SCs was southeasterly, which was mainly the case in summer. Furthermore, the emission sources contributing to PM2.5 were estimated using the correlations of organic carbon, elemental carbon, zinc, iron, manganese, and titanium concentrations in the SCs. This study demonstrated that a detailed tracking of the emission sources at a local scale is possible by analyzing the composition of the components of PM2.5.
A theory‐driven design framework for smartphone applications to support healthy and sustainable grocery shopping

Modelling behaviour has been a core topic of Psychology and the Social Sciences since their respective inception as academic disciplines. This has resulted in a fractured landscape of different theories, all addressing different aspects of behaviour. At the same time the need to formalise the design of computer and smartphone applications has spawned the field of User Experience (UX). With the convergence of everyday behaviour and the use of mobile devices the overlap between these two fields becomes ever more important. In this paper we present a comprehensive model of behaviour, integrating five well-established theories, with the aim of creating a design framework for smartphone applications that foster motivation and promote the execution of a target behaviour. The operationalisation of the approach is demonstrated by showing how to design and implement a prototypical application to support healthy and sustainable grocery shopping behaviour. While the framework proposed is not limited to this application, it is used to exemplify the relation with previous design approaches, and the concrete implications of the model-derived framework on its implementation. Our view is that both areas of research can benefit from each other: findings from behavioural theory can inform application design, while at the same time the ubiquitous integration of mobile applications allows to dynamically apply, operationalise, and implement behavioural models into everyday life.
Economic Policy Uncertainty and the Co-Movement between REITs and Exchange Rate

The REITs market has attracted a lot of interest among the academic, policymakers, and market participants. The linkages between REITs and macroeconomic and financial variables have been adequately explored in the literature, with more emphasis on linear models. This study expands the frontier of knowledge by examining the role of uncertainty in the comovement/spillover between REITs and the currency markets. Some interesting results were observed. First, using the Diebold and Yilmaz (2012) spillover test, we find that there is strong connectedness between the REITs and currency markets. Second, the BDS test shows that nonlinearity is a very crucial factor to be put into consideration when examining the role of EPU in affecting the interactions between REITs and exchange rate markets. Third, the non-parametric causality-in-quantile test confirms that the connectedness between the markets and EPU is stronger around the lower and middle quantiles. These results have important policy implications for policymakers and market participants. The study also offers suggestions for future research.
IMPLEMENTASI MODUL PENJASORKES BERMUATAN MODEL PEMBELAJARAN BANDURA UNTUK MENINGKATKAN HASIL BELAJAR PENJASORKES DAN KECERDASAN KINESTETIK SISWA SEKOLAH DASAR

Penelitian bertujuan untuk mengimplementasikan modul penjasorkes bermuatan model pembelajaran Bandura dalam meningkatkan hasil belajar penjasorkes dan kecerdasan kinestetik siswa sekolah dasar. Populasi dalam penelitian ini adalah siswa SD Laboratorium kelas IV. Penelitian ini menggunakan metode eksperimen semu dengan teknik pengambilan sampel random sampling. Jumlah sampel yang digunakan satu kelas yang berjumlah 29 orang. Analisis data dilakukan secara deskriptif dengan cara menyusun data secara sistematis, mengorganisasi data ke dalam kategori, melakukan sintesa, menyusun dalam pola tertentu, dan membuat kesimpulan. Hasil analisis data di peroleh bahwa modul penjasorkes bermuatan model pembelajaran Bandura yang diterapkan di kelas IV Sekolah Dasar Laboratorium Undiksha Singaraja menunjukkan hasil belajar yang baik dengan peningkatan kecerdasan kinestetik juga baik. Respon siswa menunjukkan bahwa 100% siswa menyatakan modul penjasorkes bermuatan model pembelajaran Bandura dapat dengan mudah dipahami dalam melatih keterampilan gerak dan kecerdasan kenestetis siswa.
Ethnographic Approach for Research on Vernacular Architecture: Four Case Studies of Indigenous Communities in Indonesia

Many ethnic groups with unique cultures exist in Indonesia, but their vernacular architecture and living cultures need to be supported to ensure sustainability. One example of how a more anthropological approach to the design and planning of the built environment requires a better understanding is the study of the living culture of indigenous communities. Unsurprisingly, an ethnographic approach is critical to studying these communities' architecture and living culture in Indonesia. This study aims to outline the main principles of the ethnographic approach and review the implementation of these principles in previous studies on the vernacular architecture of indigenous communities in Indonesia. A comparative analysis of four case studies shows that each study has implemented the approach's main principles contextually. The results showed that the four case studies utilized observation and interviews to collect field data in slightly different terms. Although each case study's objectives, focus, and issues were different, the researchers managed to provide a cultural portrait that included the participants' views (emic) and the researcher's opinions (etic). The similarities between the four communities are religious or belief systems affecting the architecture and living culture, which are cultural aspects that significantly affect each case as part of the findings embodied in themes resulting from interpretation. These results can help to develop guidelines for designers and planners working in indigenous communities. Through ethnographic studies, architects and planners can understand indigenous communities' point of view (etic) to integrate their perspectives (emic) when working hand in hand with the community.
Hypertension and beyond in Indian clinical practice study: a nationwide survey assessing knowledge, attitude and practices of physicians

Background: Hypertension is the leading cause for the ever-increasing burden of mortality due to stroke and cardiovascular diseases (CVD). Treatments are complicated due to comorbidities and can lead to patient noncompliance. Patients with low existing cardiovascular risk are prone to have higher lifetime cardiovascular risk, which timely assessment necessary.Methods: A digital cross-sectional survey questionnaire about knowledge, attitude and practice habits regarding cardiovascular risk assessment was administered to 400 physicians and cardiologists across India. The questionnaire assessed various topics such as practice of hypertension diagnosis and treatment based on guidelines, cardiovascular risk calculators, occurrence of comorbidities and patient awareness on cardiovascular risk prevention.Results: Out of the 400 physicians, 398 completed the survey. About 52% physicians considered presence of multiple risk factors as vital for having cardiovascular risk. American college of cardiology/American heart association (ACC/AHA) calculator was preferred by 51.6% study participants. Cardiovascular risk estimation was vital for treatment-related decision-making according to 71% participants, while only 7.7% participants calculated cardiovascular risk in >90% of their patients. Approximately 44% survey participants calculated cardiovascular risk in hypertensive patients with 2 additional risk factors, while 5.6% calculated it in >70% hypertensive patients without comorbidities. About 46.6% participants reported that 30%-50% of their patients were on fixed-dose combinations of two antihypertensive medications.Conclusions: Findings from the study indicate predisposition of medical professionals towards having a risk assessment tool designed for the Indian population to timely assess and forestall long-term effects of cardiovascular risk in hypertensive patients.
A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a Streptomyces Strain Collection Isolated from Leaf-Cutting Ants

The rapid emergence of bacterial resistance to antibiotics has urged the need to find novel bioactive compounds against resistant microorganisms. For that purpose, different strategies are being followed, one of them being exploring secondary metabolite production in microorganisms from uncommon sources. In this work, we have analyzed the genome of 12 Streptomyces sp. strains of the CS collection isolated from the surface of leaf-cutting ants of the Attini tribe and compared them to four Streptomyces model species and Pseudonocardia sp. Ae150A_Ps1, which shares the ecological niche with those of the CS collection. We used a combination of phylogenetics, bioinformatics and dereplication analysis to study the biosynthetic potential of our strains. 51.5% of the biosynthetic gene clusters (BGCs) predicted by antiSMASH were unknown and over half of them were strain-specific, making this strain collection an interesting source of putative novel compounds.