Miracle-dz/UniFAR-FTUs huggingface dataset:
A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study

Background Self-reported adherence to the Mediterranean diet has been modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured biomarker of the Mediterranean diet. Methods and findings We derived a biomarker score based on 5 circulating carotenoids and 24 fatty acids that discriminated between the Mediterranean or habitual diet arms of a parallel design, 6-month partial-feeding randomised controlled trial (RCT) conducted between 2013 and 2014, the MedLey trial (128 participants out of 166 randomised). We applied this biomarker score in an observational study, the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, to assess the association of the score with T2D incidence over an average of 9.7 years of follow-up since the baseline (1991 to 1998). We included 22,202 participants, of whom 9,453 were T2D cases, with relevant biomarkers from an original case-cohort of 27,779 participants sampled from a cohort of 340,234 people. As a secondary measure of the Mediterranean diet, we used a score estimated from dietary-self report. Within the trial, the biomarker score discriminated well between the 2 arms; the cross-validated C-statistic was 0.88 (95% confidence interval (CI) 0.82 to 0.94). The score was inversely associated with incident T2D in EPIC-InterAct: the hazard ratio (HR) per standard deviation of the score was 0.71 (95% CI: 0.65 to 0.77) following adjustment for sociodemographic, lifestyle and medical factors, and adiposity. In comparison, the HR per standard deviation of the self-reported Mediterranean diet was 0.90 (95% CI: 0.86 to 0.95). Assuming the score was causally associated with T2D, higher adherence to the Mediterranean diet in Western European adults by 10 percentiles of the score was estimated to reduce the incidence of T2D by 11% (95% CI: 7% to 14%). The study limitations included potential measurement error in nutritional biomarkers, unclear specificity of the biomarker score to the Mediterranean diet, and possible residual confounding. Conclusions These findings suggest that objectively assessed adherence to the Mediterranean diet is associated with lower risk of T2D and that even modestly higher adherence may have the potential to reduce the population burden of T2D meaningfully. Trial registration Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12613000602729 https://www.anzctr. org.au/Trial/Registration/TrialReview.aspx? id=363860.
Large-Scale Atmospheric Conditions During the Intensification of Hurricane Carmen (1974) I. Temperature, Moisture and Kinematics

Abstract A diagnostic analysis is presented of the large-scale atmospheric conditions in the Caribbean area during the 4-day period of Hurricane Carmen's (1974) development and intensification. Data taken during the Global Atmospheric Research Program's (GARP) Atlantic Tropical Experiment (GATE) form the basis for the study and consist primarily of rawinsonde reports at standard pressure levels. Analyses of the following observed and computed quantities are performed at 12 h intervals: wind direction and speed, u and v wind components, geopotential height, air temperature, equivalent potential temperature, sea surface temperature, relative humidity, vertical motion, horizontal divergence, relative and absolute vorticity, and vorticity budget terms. It is seen that several features of the large-scale circulation persist in Camen's vicinity throughout the 4-day period. These include warm sea surface temperatures, low-level conditional instability, a deep moisture-rich layer, low-level confluence and upper l.
Late recurrence of atrial fibrillation 5 years after catheter ablation: predictors and outcome

Abstract Aims Atrial fibrillation (AF) is a chronic progressive disease that continuously recurs even after successful AF catheter ablation (AFCA). We explored the mechanism of long-term recurrence by comparing patient characteristics and redo-ablation findings. Methods and results Among the 4248 patients who underwent a de novo AFCA and protocol-based rhythm follow-up at a single centre, we enrolled 1417 patients [71.7% male, aged 60.0 (52.0–67.0) years, 57.9% paroxysmal AF] who experienced clinical recurrences (CRs), and divided them according to the period of recurrence: within one year (n = 645), 1–2 years (n = 339), 2–5 years (n = 308), and after 5 years (CR>5 yr, n = 125). We also compared the redo-mapping and ablation outcomes of 198 patients. In patients with CR>5 yr, the proportion of paroxysmal AF was higher (P = 0.031); however, the left atrial (LA) volume (quantified by computed tomography, P = 0.003), LA voltage (P = 0.003), frequency of early recurrence (P < 0.001), and use of post-procedure anti-arrhythmic drugs (P < 0.001) were lower. A CR>5 yr was independently associated with a low LA volume [odds ratio (OR) 0.99 (0.98–1.00), P = 0.035], low LA voltage [OR 0.61 (0.38–0.94), P = 0.032], and lower early recurrence [OR 0.40 (0.23–0.67), P < 0.001]. Extra-pulmonary vein triggers during repeat procedures were significantly greater in patients with a CR>5 yr, despite no difference in the de novo protocol (P for trend 0.003). The rhythm outcomes of repeat ablation procedures did not differ according to the timing of the CR (log-rank P = 0.330). Conclusions Patients with a later CR exhibited a smaller LA volume, lower LA voltage, and higher extra-pulmonary vein triggers during the repeat procedure, suggesting AF progression.
High-protein dried distillers grains in dog diets: diet digestibility and palatability, intestinal fermentation products, and fecal microbiota.

This study aimed to evaluate the effects of high-protein dried distillers grains (HPDDG) on palatability and metabolizable energy (ME) of the diet, apparent total tract digestibility (ATTD) of nutrients and energy, intestinal fermentation products, and fecal microbiota in dogs. Four diets containing 0, 70, 140, and 210 g/kg of HPDDG were manufactured. To evaluate the ME and the ATTD of macronutrients of HPDDG itself, an additional test diet was manufactured containing 70% of the control diet formula (0 g/kg) and 300 g/kg of HPDDG. Fifteen adult Beagle dogs were distributed in a randomized block design, with two periods of 15 days each (n=6). The HPDDG digestibility was obtained using the Matterson substitution method. For the palatability test, 16 adult dogs were used, comparing the diets: 0 vs. 70 g/kg of HPDDG and 0 vs. 210 g/kg of HPDDG. The ATTD of HPDDG were: dry matter = 85.5%, crude protein = 91.2%, and acid hydrolyzed ether extract = 84.6% and the ME content was 5041.8 kcal/kg. The ATTD of macronutrients and ME of the diets and the fecal dry matter, score, pH, and ammonia of the dogs did not differ among treatments (P>0.05). There was a linear increase in the fecal concentrations of valeric acid with the inclusion of HPDDG in the diet (P<0.05). Streptococcus and Megamonas genera reduced linearly (P<0.05), and Blautia, Lachnospira, Clostridiales, and Prevotella genera showed a quadratic response to the inclusion of HPDDG in the diet (P<0.05). Alpha-diversity results showed an increase (P<0.05) in the number of OTUs and Shannon index and a trend (P=0.065) for a linear increase in the Chao-1 index with the dietary inclusion of HPDDG. Dogs preferred the 210 g/kg diet over the 0 g/kg HPDDG diet (P<0.05). These results demonstrate that the HPDDG evaluated does not affect the utilization of nutrients in the diet, but it may modulate the fecal microbiome of dogs. In addition, HPDDG may contribute to diet palatability for dogs.
Association of the etiology and peak level of markedly elevated aminotransferases with mortality: a multicenter study

Background: Markedly elevated aminotransferase levels are commonly encountered among hospitalized patients. However, data regarding the trajectory of enzyme elevation and disease-specific prognosis are limited. Methods: This study included 3237 patients with at least one episode of aspartate aminotransferase or alanine aminotransferase level being higher than 400 U/L between January 2010 and December 2019 at 2 centers. Patients were classified into 5 groups comprising 13 diseases according to etiology. Factors associated with 30-day mortality were evaluated using a logistic regression analysis. Results: The most common disease leading to markedly elevated aminotransferase level was ischemic hepatitis (33.7%), followed by pancreatobiliary disease (19.9%), DILI (12.0%), malignancy (10.8%), and viral hepatitis (7.0%). The 30-day all-cause mortality rate was 21.6%. The mortality rate for patients from the pancreatobiliary, hepatocellular, extrahepatic, malignancy, and ischemic hepatitis groups was 1.7%, 3.2%, 13.8%, 39.9%, and 44.2%, respectively. Age, etiology, and peak aminotransferase levels were independently associated with 30-day mortality. Conclusions: In patients with markedly elevated liver enzymes, the etiology and peak AST level are significantly associated with mortality.
The Rapid Growth and Decay of an Extratropical Cyclone over the Central Pacific Ocean

Abstract The life cycle of a central Pacific cyclone, characterized by a 48-h interval of rapid fluctuation in its intensity, is examined. The cyclone of interest underwent a period of explosive cyclogenesis from 1200 UTC 4 November to 1200 UTC 5 November 1986, followed 12 h later by a period of unusually rapid decay. Output from a numerical simulation of this event, run using the fifth-generation Pennsylvania State University–National Center for Atmospheric Research (PSU–NCAR) Mesoscale Model (MM5), is used to perform a piecewise potential vorticity (PV) inversion in order to diagnose the life cycle of this unusual cyclone. The analysis reveals that the presence of lower-tropospheric frontogenetic forcing in an environment characterized by reduced static stability (as measured by high values of the K index) produced a burst of heavy precipitation during the development stage of the cyclone's life cycle. The associated latent heat release produced a substantial diabatic PV anomaly in the middle tropospher.
Composition dependence of magnetic properties in perpendicularly magnetized epitaxial thin films of Mn-Ga alloys

Mn-Ga binary alloys show strong magnetism and large uniaxial magnetic anisotropy even though these alloys do not contain any noble, rare-earth metals or magnetic elements. We investigate the composition dependence of saturation magnetization ${M}_{\mathrm{S}}$ and uniaxial magnetic anisotropy ${K}_{\mathrm{u}}$ in epitaxial films of Mn${}_{x}$Ga${}_{1\ensuremath{-}x}$ alloys ($x\ensuremath{\sim}0.5$--0.75) grown by magnetron sputtering. The ${M}_{\mathrm{S}}$ values decrease linearly from approximately 600 to 200 emu/cm${}^{3}$ with increasing $x$, whereas the ${K}_{\mathrm{u}}$ values decrease slightly from approximately 15 to 10 Merg/cm${}^{3}$ with increasing $x$. These trends are distinct from those for known tetragonal hard magnets obtained in a limited composition range in Mn-Al and Fe-Pt binary alloys. These data are analyzed using a localized magnetic moment model.
The end of the dark ages in modified Newtonian dynamics

We study the evolution of a spherically symmetric density perturbation in the Modified Newtonian Dynamics model applied to the net acceleration over Hubble flow. The background cosmological model is a A-dominated, low-Ω b Friedmann model with no cold dark matter. We include thermal processes and non-equilibrium chemical evolution of the collapsing gas. We find that under these assumptions the first low-mass objects (M ≤ 3 × 10 4 M○.) may collapse already for z ∼ 30, which is in quite good agreement with the recent Wilkinson Microwave Anisotropy Probe results. A lower value of a 0 would lead to much slower collapse of such objects.
Systemic risk prevention policies targeting systemically important banks: Does clustering pattern matter?

It is well known that strengthening the soundness of individual banks that are too large or too interconnected is essential for maintaining financial stability. The clustering among homogeneous banks may also cause financial fragility but has received less attention. This paper discusses the policy improvement for preventing systemic risk from the perspective of the clustering pattern of systemically important banks (SIBs) based on a network optimization model. The results show that the clustering pattern of SIBs is closely related to systemic risk contagion. Remarkably, networks with fewer connections among SIBs exhibit lower systemic risk than those featuring apparent clustering of SIBs. The potential mechanism is that the systemic vulnerability of small and medium-sized banks is greatly reduced in the disassortative networks. The proposed tools based on this—inter-SIBs exposure limits and pairwise capital requirements—can guide network optimization and significantly reduce systemic risk. Furthermore, combining existing capital surcharges for SIBs (focusing on the stability of individual SIBs) and proposed network-based tools (focusing on the cluster structure of the network) will be an effective way to enhance financial stability over existing policies.
Dating Violence, Sexual Violence, and Bullying Victimization Among High School Students —Youth Risk Behavior Survey, United States, 2021

Experiences of teen dating violence (TDV), sexual violence, and bullying during adolescence are all forms of interpersonal violence victimization (IVV) and are associated with health and behavioral issues during adulthood. Data from the nationally representative 2011–2021 Youth Risk Behavior Surveys were used to estimate the 2021 prevalence of IVV reported by U.S. high school students. IVV included past-year sexual TDV, physical TDV, sexual violence by anyone, electronic bullying, being bullied on school property, and lifetime forced sex and was analyzed by demographic characteristics and sex of sexual contacts. This report also explored trends in IVV over this 10-year period among U.S. high school students. In 2021, a total of 8.5% of students reported physical TDV, 9.7% reported sexual TDV, 11.0% reported sexual violence by anyone (with 59.5% of those also reporting sexual TDV), 15.0% reported bullying on school property, and 15.9% reported electronic bullying victimization during the past 12 months; 8.5% also reported experiencing forced sex in their lifetime. Disparities were observed for each form of IVV assessed for females and for most forms of IVV among racial and ethnic minority students; students who identified as lesbian, gay, bisexual, questioning, or other (LGBQ+); and students who reported their sexual contacts as same sex only or both sexes. Trend analyses indicated that physical TDV, sexual TDV, any physical or sexual TDV, and both physical and sexual TDV victimization decreased from 2013 to 2021 (although sexual TDV increased from 2019 to 2021). Any bullying victimization decreased from 2011 to 2021. Lifetime forced sexual intercourse decreased from 2011 to 2015, then increased from 2015 to 2021. Being bullied on school property was unchanged from 2011 to 2017, then decreased from 2017 to 2021. Sexual violence by anyone increased from 2017 to 2021. This report highlights disparities in IVV and provides the first national estimates among Native Hawaiian or other Pacific Islander youths. Findings, including trend analyses indicating recent increases in certain forms of IVV, point to the continued urgency of violence prevention efforts for all U.S. youths and especially those who are disproportionately affected by IVV.
Dental stem cells for tooth regeneration: how far have we come and where next?

ABSTRACT Introduction Human dental stem cells are promising for tooth repair because of their differentiation potential. In 2018, this journal published a report on dental stem cell treatment options that had been attempted since the early 2000s. Although it is very difficult to follow every trend since then, new achievements have been made in the last 5 years. This review summarizes selected developments in dental stem cell research. Areas covered This article provides an overview of new developments with human dental stem cells and parts of these cells like extracellular vesicles for regenerative medicine. Preclinical research, clinical trials, and other works in the field of dental stem cells research for whole tooth engineering, dental pulp regeneration, periodontitis, and tooth root regeneration are summarized. In addition, works with dental stem cells for the regeneration of diseases that cannot be cured with the regeneration of dental tissues, such as diabetes, will be presented. Expert opinion Over the past five years, a number of studies using dental stem cells have improved new strategies for tooth repair. In addition, there are new dental stem cell products such as extracellular vesicles which, in combination with findings from basic research, will lead to new treatment options in the future.
Peak height velocity in young athletes: A longitudinal meta-analysis

ABSTRACT The present longitudinal meta-analysis aimed to estimate the growth curves and age at peak height velocity (PHV) in young male athletes, considering anthropometric data from available longitudinal studies. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, studies with repeated measurements in young male athletes were identified from searches across four databases (MEDLINE, SPORTDiscus, Web of Science, and SCOPUS). Estimations were based on multilevel polynomial models using a fully Bayesian framework. After a full-text screening of 317 studies meeting the eligibility criteria, 31 studies were considered. Studies were excluded mainly due to study design, repeated reporting, and incomplete reporting of the outcomes. Of the 31 studies analysed, 26 (84%) focused on young European athletes. The average age at PHV for the total sample of studies with young athletes was 13.1 years (90% credible interval: 12.9; 13.4). When considering data by sport, there was substantial variation in the age at PHV estimates (range: 12.4 to 13.5 years). As most studies in the meta-analysis focused on young European football players (52%), predictions for young athletes from other sports may be limited. The age at PHV in the available data occurred earlier than in general paediatric populations.
Update on adherence to guidelines for time to initiation of postoperative radiation for head and neck squamous cell carcinoma

A prior study reported that over half of patients with HNSCC initiated PORT after 6 weeks from surgery during 2006–2014. In 2022, the CoC released a quality metric for patients to initiate PORT within 6 weeks. This study provides an update on time to PORT in recent years.
Motivators and barriers to research participation among medical students in Saudi Arabia

Little is known about the obstacles medical students face when conducting research in Saudi Arabia. Moreover, the proportion of medical students in research has been unknown in our region compared to other regions. We sought to identify the barriers and motivators that influence undergraduate medical students in pursuing research. This was a cross-sectional study design, utilizing an online survey distributed through social media platforms from the 17th of December 2021 to the 8th of April 2022. The survey was distributed to four universities in Saudi Arabia. Participants’ characteristics, details regarding involvement in research, and attitude towards research were collected. Frequency measures were used to characterize the demographics and chi-squared tests to determine associations. A total of 435 students were included in the final analysis. The highest proportion of students that responded were second year, followed by first year medical students. Less than half (47.6%) of medical students were involved in research. A significant correlation was revealed between the involvement in research and higher participants’ Grade Point Average (GPA). The top three incentives for pursuing undergraduate research were “admission into residency programs” (44.8%), “interest in research” (28.7%), and “financial return” (10.8%). However, the top three limitations were “lack of time” (29.2%), “lack of mentoring” (16.8%), and “lack of interest in research” (14.7%). System-related barriers and motivators were the main reasons behind the involvement of medical students in research. Our study is a call for action to raise awareness among medical students about the importance of research and to provide solutions to overcome these barriers.
Influenza vaccine hesitancy and influencing factors among university students in China: a multicenter cross-sectional survey

Abstract Aim Highly mutable and contagious influenza poses a serious health threat to university students and their close contacts. Although annual influenza vaccination is an effective way to prevent influenza, influenza vaccination rates among Chinese university students are still low due to vaccine hesitancy. This study investigated Chinese university students’ hesitancy to receive influenza vaccine and its influencing factors during the COVID-19 pandemics based on WHO’s vaccine hesitancy matrix. Methods A multicenter cross-sectional study of university students in four cities across China was conducted via a web-based questionnaire in June 2022. Binary logistic regression was adopted to determine the factors around contextual influences, individual and group influences, and vaccines/vaccination specific issues. The reliability and validity of the questionnaire were good, with a Kronbach alpha coefficient of 0.892 and a KMO coefficient of 0.957. Results Of the 2261 Chinese university students surveyed, 44.7% had influenza vaccine hesitancy. Binary logistic regression showed that students considering high severity (OR = 0.946) or probability (OR = 0.942) of getting influenza, trusting vaccine-related advice from medical personnel (OR = 0.495) had lower odds of hesitancy. The odds of influenza vaccine hesitancy were higher if the students believed that vaccination was not necessary (OR = 4.040), had not been recommended by people around (OR = 1.476) and had no previous vaccinations or appointments (OR = 2.685). Conclusions Medical staff are suggested to provide health education, improve doctor-patient communication and recommend vaccinations to university students to increase their risk perception and willingness to get an influenza vaccination. Collective vaccination strategies can be implemented to reduce the vaccine hesitancy for students.