Miracle-dz/UniFAR-FTUs huggingface dataset:
A prospective randomised study on efficacy of music for decreasing preoperative anxiety in children

Background The operating room can be a frightening environment for paediatric patients. This study investigated whether music medicine can mitigate preoperative anxiety in children. Materials and methods One hundred and fifty children undergoing general anaesthesia were randomised to listen to music of the child’s choice, lullaby music or no music before induction. Heart rates were measured in the waiting room, upon first entry into the operating room and just prior to induction. Results There was no significant difference in average heart rate change from the waiting room to induction in the patient choice, lullaby and control groups. Older age was associated with higher heart rate changes between baseline and entering the operating room. Pharmacologic sedation showed a significant beneficial effect on heart rate change at induction. Conclusion Use of music medicine in the operating room does not show efficacy to reduce anxiety in children based on heart rate changes.
Transient Hypoxia Model Revealed Cerebrovascular Impairment in Anemia Using BOLD MRI and Near‐Infrared Spectroscopy

Obstructive sleep apnea and nocturnal oxygen desaturations, which are prevalent in sickle cell disease (SCD) and chronic anemia disorders, have been linked to risks of stroke and silent cerebral infarcts (SCI). Cerebrovascular response to intermittent desaturations has not been well studied and may identify patients at greatest risk.
Protein unfolding at interfaces: Slow dynamics of α‐helix to β‐sheet transition

A two‐phase sequential dynamic change in the secondary structure of hen egg lysozyme (Lys) adsorbed on solid substrates was observed. The first phase involved fast conversion of α‐helix to random/turns (within the first minute or at very low coverage or high substrate wettability) with no perceptible change in β‐sheet content. The second phase (1–1200 min), however, involved a relatively slow conversion from α‐helix to β‐sheet without a noticeable change in random/turns. An important finding of this work is that the concentration of lysozyme in the adsorbed state has a substantial effect on the fractional content of secondary structures. Attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy, along with a newly‐developed optimization algorithm for predicting the content of secondary structure motifs, was used to correlate the secondary structure and the amount of adsorbed lysozyme with the surface wettability of six different flat nanoporous substrates. Although three independent variables, surface wettability, solution concentration and time for adsorption, were used to follow the fractional structural changes of lysozyme, the results were all normalized onto a single plot with the amount adsorbed as the universal independent variable. Consequently, lateral interactions among proteins likely drive the transition process. Direct intermolecular force adhesion measurements between lysozyme and different functionalized self‐assembled alkanethiol monolayers confirm that hydrophobic surfaces interact strongly with proteins. The lysozyme‐unfolding pathway during early adsorption appears to be similar to that predicted by published molecular modeling results. Proteins 2004. © 2004 Wiley‐Liss, Inc.
Nitrogen and phosphorus excretion on commercial rabbit farms: calculations based on the input-output balance.

Manure is no longer exclusively considered as a fertiliser in areas with high densities of farm animals. Efforts are being made to reduce mineral excretion or to stimulate a more environmentalfriendly use. In such a context, both from the governmental side and for the producer, a reliable calculation of the on-farm production is very useful. Based on the balance between input (feed) - output (produced rabbits, dead rabbits), the nitrogen and phosphorus on farm excretion have been calculated for different production systems, production levels and slaughter weights. For a closed farm (breeding + fattening) the most convenient expression of mineral excretion is per female on average present on the farm. The excretion amounts to 7.42 kg N and 4.76 kg P2O5 per doe/year on a commercial rabbit farm based on an average production/doe of 45 fatteners of 2.5 kg. The excretion decreases from 76 to 61 g N and from 48 to 40 g P2O5 /kg rabbit produced with increasing productivity of the farm (35 vs 50 delivered fatteners/doe/year, respectively). In an exclusively fattening unit (between 0.8 and 2.5 kg weight and a feed conversion ratio of 3.40), the excretion amounts to 38 g N and 26 g P2O5, per kg rabbit produced.
Impact of Virtual Synchronous Generators on Inter-Area Low Frequency Oscillation

With the rapid development of Virtual Synchronous Generators (VSG) technology, the influence mechanism of VSG on the low frequency oscillation characteristics of power system has become an issue that needs urgent research. In this paper, small-signal models of synchronous generators (SG) and VSG were established. Eigenvalue analysis were conducted to identify how frequency regulation ability and inertia of SG and VSG effect on low frequency oscillation. The comparison between both SG and VSG are implemented to clarify why their low frequency oscillation characteristics are different. Finally, the results revealed that the virtual impedance control of VSG is the key reason to make the oscillation characteristic of VSG different from SG. If the virtual impedance is small enough, the influence of VSG on low frequency oscillation will be similar to SG.
The effects of ten weeks resistance training on sticking region in chest-press exercises

The aim of the study was to compare the effects of a 10-week chest-press resistance training on lifting regions in a trained exercise and a none-trained exercise; the barbell bench press (BBP). Thirty-five resistance trained men with 4.2 (± 2.3) years of resistance training experience were recruited. The participants were randomized to attend a resistance program, performing the chest-press, twice per week using either, Smith machine, dumbbells or laying on Swiss ball using a barbell. A six-repetitions maximum (6RM) test was conducted pre- and post-training in the trained chest-press exercise and non-trained BBP to examine lifting velocity, load displacement and the time of the pre-sticking, sticking and post-sticking regions. Additionally, the muscle activity in pectoralis major, triceps brachii, biceps brachii and deltoid anterior was examined. In the post-test, all three chest-press groups decreased lifting velocity and increased the time to reach the sticking- and post-sticking region. Independent of the type of chest-press exercise trained, no differences were observed in vertical displacement or in the muscle activity for the three lifting regions. In general, similar changes in kinematics in trained exercise and those observed in the BBP were observed for all three groups. This indicates that none of the three chest-press exercises (Swiss ball, Smith machine or dumbbells) were specific regarding the lifting regions but displaced a transferability towards the non-trained BBP. However, improved strength altered the sticking region among resistance trained men.
Seasonal distribution of large phytoplankton in the Keban Dam Reservoir

The Keban Dam Reservoir (KDR), in eastern Anatolia, is one of the largest man-made reservoirs of the world with a storage capacity of >30 billion m 3 . In the KDR, long-term water quality surveys have been carried out in order to determine the trophic status of this rather unique reservoir. In this paper, the focus is on the large phytoplankton species that were identified during the field studies conducted between 1991 and 1993. According to the results of the surveys, the overall phyto- plankton density is low during the fall and winter months. However, species belonging to various groups started to become abundant in the spring when the water level began to rise. In terms of species diversity, the most dominant group was the Bacillariophyta. Other dominant species belonged to the Cyanophyta, Chloropyta, Pyrrophyta, Chrysophyta and Euglenophyta. The effects of various physic- ochemical quality parameters on the seasonal distribution and succession of the above taxa, as well as the interrelation with eutrophication, are also discussed.
Survey on the situation of telepharmacy as applied to the outpatient care in hospital pharmacy departments in Spain during the COVID-19 pandemic.

OBJECTIVE To analyze the status of the implementation and development of telepharmacy as applied to the pharmaceutical care of outpatients treated at hospital pharmacy services in Spain during the COVID-19 pandemic. METHOD Six weeks after the beginning of the confinement period, an online 10- question survey was sent to all members of the Spanish Society of Hospital Pharmacists. A single response per hospital was requested. The survey included questions on the provision of remote pharmaceutical care prior to the onset of the health crisis, patient selection criteria, procedures for home delivery of medications and the means used to deliver them, the number of patients who benefited from telepharmacy, and the number of referrals made. Finally, respondents were asked whether a teleconsultation was carried out before sending patients their medication and whether these deliveries were recorded. RESULTS A total of 39.3% (n = 185) of all the hospitals in the National Health System (covering all of Spain's autonomous regions) responded to the survey. Before the beginning of the crisis, 83.2% (n = 154) of hospital pharmacy services did not carry out remote pharmaceutical care activities that included telepharmacy with remote delivery of medication. During the study period, 119,972 patients were treated, with 134,142 deliveries of medication being completed. Most hospitals did not use patient selection criteria. A total of 30.2% of hospitals selected patients based on their personal circumstances. Home delivery and informed delivery (87%; 116,129 deliveries) was the option used in most cases. The means used to deliver the medication mainly included the use of external courier services (47.0%; 87 hospitals) or the hospital's own transport services (38.4%; 71 hospitals). As many as 87.6% of hospitals carried out teleconsultations prior to sending out medications and 59.6% recorded their telepharmacy activities in the hospital pharmacy appointments record. CONCLUSIONS The rate of implementation of telepharmacy in outpatient care in Spain during the study period in the pandemic was high. This made it possible to guarantee the continuity of care for a large number of patients.
Response of Dovekie to Changes in Food Availability

Abstract Dovekie (Alle alle) parents feed their chicks almost exclusively with high energy Arctic zooplankton associated with cold polar waters. In years with a stronger influx of warm Atlantic waters (positive NAO index) in their traditional feeding grounds, they may be forced to forage in suboptimal feeding areas. We compared the Dovekie chick diet in Hornsund (Spitsbergen) in the early, mid and late phases of the chick-rearing period in two seasons with different distributions of cold (Arctic) and warm (Atlantic) water masses. Parents delivered to their chicks food loads of lower wet weight (in the mid and late phase) and lower energetic value (in the late phase) under warm water conditions compared to colder water conditions. This suggests worse foraging conditions for Dovekies and foraging in suboptimal feeding areas during warm water events. However, data from the mid phase showed that Dovekies are able to compensate by increasing the number of daily feedings. In this phase, chicks received the same amount of food (by mass and energy) as in cold years. It is unknown how large the inflow of Atlantic water can be before it has negative implications for adult Dovekie daily time budget, body condition, survival rate, their breeding success and fitness.
Effect of Repetitive Transcranial Magnetic Stimulation on a Target Moving in Front of a Static or Random Dynamic Visual Noise

Observers report seeing as slower a target disk moving in front of a static visual noise (SVN) background than the same object moving in front of a random dynamic visual noise (rDVN) background when the speed is the same. To investigate in which brain region (lower vs. higher visual areas) the background and the target signals might be combined to elicit this misperception, the transcranial magnetic stimulation (TMS) was delivered over the early visual cortex (V1/V2), middle temporal area (MT) and Cz (control site) while participants performed a speed discrimination task with targets moving in front of an SVN or an rDVN. Results showed that the TMS over MT reduced the perceived speed of the target moving in front of an SVN, but not when the target was moving in front of an rDVN background. Moreover, the TMS do not seem to interfere with encoding processing but more likely affected decoding processing in conditions of high uncertainty (i.e., when targets have similar speed).
Nonculprit Lesion Plaque Morphology in Patients With ST-Segment–Elevation Myocardial Infarction

Supplemental Digital Content is available in the text. Background: Complete revascularization with routine percutaneous coronary intervention of nonculprit lesions after primary percutaneous coronary intervention improves outcomes in ST-segment–elevation myocardial infarction. Whether this benefit is associated with nonculprit lesion vulnerability is unknown. Methods: In a prospective substudy of the COMPLETEs trial (Complete vs Culprit-Only Revascularization to Treat Multi-Vessel Disease After Early PCI for STEMI), we performed optical coherence tomography of at least 2 coronary arteries before nonculprit lesion percutaneous coronary intervention in 93 patients with ST-segment–elevation myocardial infarction and multivessel disease; and the ST-segment–elevation myocardial infarction culprit vessel if there was unstented segment amenable to imaging. Nonculprit lesions were categorized as obstructive (≥70% stenosis by visual angiographic assessment) or nonobstructive, and as thin-cap fibroatheroma (TCFA) or non-TCFA by optical coherence tomography criteria. TCFA was defined as a lesion with mean fibrous cap thickness <65 μm overlying a lipid arc >90°. Results: On a patient level, at least one obstructive TCFA was observed in 44/93 (47%) of patients. On a lesion level, there were 58 TCFAs among 150 obstructive nonculprit lesions compared with 74 TCFAs among 275 nonculprit lesions (adjusted TCFA prevalence: 35.4% versus 23.2%, P=0.022). Compared with obstructive non-TCFAs, obstructive TCFAs had similar lesion length (23.1 versus 20.8 mm, P=0.16) but higher lipid quadrants (55.2 versus 19.2, P<0.001), greater mean lipid arc (203.8° versus 84.5°, P<0.001), and more macrophages (97.1% versus 54.4%, P<0.001) and cholesterol crystals (85.8% versus 44.3%, P<0.001). For nonobstructive lesions, TCFA lesions had similar lesion length (16.7 versus 14.6 mm, P=0.11), but more lipid quadrants (36.4 versus 13.5, P<0.001), and greater mean lipid arc (191.8° versus 84.2°, P<0.001) compared with non-TCFA. Conclusions: Among patients who underwent optical coherence tomography imaging in the COMPLETE trial, nearly 50% had at least one obstructive nonculprit lesion containing complex vulnerable plaque. Obstructive lesions more commonly harbored vulnerable plaque morphology than nonobstructive lesions. This may help explain the benefit of routine percutaneous coronary intervention of obstructive nonculprit lesions in patients with ST-segment–elevation myocardial infarction and multivessel disease. Registration: URL: https://www.clinicaltrials. gov. Unique identifier: NCT01740479s.
Effects of Liraglutide on Cardiovascular Outcomes in Type 2 Diabetes Patients With and Without Baseline Metformin Use: Post Hoc Analyses of the LEADER Trial

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) reduce cardiovascular (CV) events among patients with type 2 diabetes and high CV risk. Because consensus professional society recommendations endorse metformin as the first-line medication for type 2 diabetes, the CV efficacy of GLP-1RAs has primarily been studied with background metformin therapy (1). However, the European Society of Cardiology now recommends GLP-1RAs as a first-line type 2 diabetes treatment for patients at high CV risk (2). These discordant recommendations raise the question of how background metformin might influence the CV benefits of GLP-1RAs. Using data from the LEADER trial, we sought to answer this question by exploring possible heterogeneity in the CV efficacy of liraglutide related to baseline metformin treatment (3). The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial (NCT01179048, ClinicalTrials.gov) has been described elsewhere (3). Patients with type 2 diabetes and high CV risk underwent double-blind randomization to daily liraglutide versus placebo in addition to existing care. Each patient contributed data from randomization until censoring. The primary outcome was time from randomization to first occurrence of a composite of CV death, myocardial infarction, or stroke. Prespecified secondary outcomes included an expanded composite (primary plus coronary revascularization or hospitalization for unstable angina or heart failure), the composite components, and all-cause death. All outcomes were centrally adjudicated. Metformin treatment was identified at the baseline trial visit and each visit thereafter. Within each baseline metformin treatment subgroup, effect estimates for liraglutide versus placebo (hazard ratio [HR], 95% CI) were derived using Cox proportional hazards regression models; multivariable adjustment for baseline demographic and clinical factors was performed. Inverse probability for treatment weighting (IPTW) was used to account for imbalances in covariates between baseline metformin treatment subgroups (4). For multivariable analyses with IPTW, heterogeneity in the association between baseline metformin …
SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer

The solute carrier (SLC) family is the largest group of membrane transporters, but their functions in ovarian cancer (OV) remain unclear. We analyzed SLC family members with amino acids-transporting functions in OV. The mRNA expression levels and prognostic values of SLCs in OV were analyzed in the Gene Expression Profiling Interactive Analysis and Kaplan–Meier Plotter database. Solute carrier family 7 member 2 (SLC7A2), which showed differential expression and the most significant prognostic value, was selected for further analyses. The cBioPortal database, Gene Set Enrichment Analysis and Weighted Correlation Network Analysis were used to explore the potential functions and molecular mechanisms of SLC7A2 in OV. Validations in our own samples and in Gene Expression Omnibus datasets were conducted. Functional validation in OV cell lines was carried out. In total, 73 SLC family members were analyzed. Seven members were upregulated while 11 members were downregulated in OV and 15 members were protective factors for prognosis while 12 members were risk factors. SLC7A2 was downregulated in OV, and it was positively associated with prognosis. Knockdown of SLC7A2 promoted viability, invasion and migration of OV cells. These SLC family members and in particular SLC7A2 represented novel biomarkers for diagnosis and treatment for OV.
Conservation Genetics of an Imperiled Riverine Fish from Eastern North America, the Blotchside Logperch, Percina Burtoni (Teleostei: Percidae)

Abstract Percina burtoni (Percidae: subgenus Percina), Blotchside Logperch, historically occupied much of the Tennessee and Cumberland River drainages, but is now restricted to highly fragmented populations where they occur at low densities. Widespread impoundment and subsequent river alteration over the past 60 years has eliminated many populations and reduced the potential for dispersal and gene flow between extant populations. We examined genetic variation at two mitochondrial genes, cytochrome b and ND2, from 74 individuals in ten populations to assess genetic population structure within P. burtoni. These data, as well as the results of recent surveys, were used to assess conservation priorities for this imperiled fish. Phylogenetic analysis recovered two well supported and highly differentiated clades within P. burtoni, one containing individuals from the Duck River drainage and a small tributary to the lower Tennessee River, and the other composed of individuals from the middle and upper Tennessee River drainage. The Duck River clade exhibits lower haplotypic and nucleotide diversity than the Tennessee River clade and shows little geographic partitioning. In contrast, most populations of middle and upper Tennessee River P. burtoni possess unique haplotypes and show strong geographic differentiation. Historical isolation of small populations in tributary systems of the upper Tennessee Basin is hypothesized to be responsible for observed patterns of differentiation within this clade. These results have implications for reintroduction programs and population augmentation with captive-reared individuals. Propagation activities should take fine-scale geographic structure into account prior to any reintroduction activities.
Exploring the spatial working memory and visual perception in children with autism spectrum disorder and general population with high autism-like traits

The aim of the study is to compare the spatial working memory and visual perception between children with autism spectrum disorder (ASD) and typically developing control (TDC). Furthermore, this study validated whether this impairment was a feature of autism in general population with different autism-like traits (ALTs). This study contains two parts: case-control study and community population study. The ASD group and the control group were enlisted voluntarily (ASD group, n = 52; control group, n = 32). In the population study, we recruited 2994 children. Based on the scores of Autism Spectrum Quotient (AQ), children were divided into two groups (higher ALTs n = 122, lower ALTs n = 122). The participants completed the cognition tasks focusing on spatial working memory, visual-motor integration, and Intelligence. Analysis of covariance (ANCOVA) was conducted, with potential confounders IQ, age, and gender were controlled. Pearson correlations were computed by controlling the IQ and age as covariate to better understand the relations between visual perception, spatial working memory, and autism-like traits. In the case-control study, the results of cognition tasks focusing on the spatial working memory and visual perception indicated underperformance in children with ASD. In the community population study, we found that individuals with higher ALTs performed worse than children with lower ALTs in spatial working memory. Pearson correlation analysis suggested that a correlation between SWM total errors and visual perception was identified both in the children with ASD and in community population (ASD group, r = -0.592, p<0.001; general population, r = -0.201, p = 0.003). It suggested that spatial working memory deficit was a characteristic of autism, and may be distributed across the general population. Furthermore, we speculated a correlation between spatial working memory and visual perception in children with ASD and in general population.