Miracle-dz/UniFAR-FTUs huggingface dataset:
Decapod crustaceans in benthic habitats of the Turkish Straits System with new records

Abstract The objective of this study was to investigate decapod species occurring in the Turkish Straits System. For this purpose, benthic samples were collected from six different biotopes (photophilic algae, Cystoseira barbata, meadows, Posidonia oceanica, mussel, Mytilus galloprovincialis, meadows, Zostera marina, serpulid reef, and rocks) at depths ranging from 10 to 1000 m. A total of 60 species of decapod crustaceans were identified, including new records for the Turkish Straits System: Processa elegantula, P. modica, Richardina fredericii, Callianassa subterranea, Gourretia denticulata, Inachus parvirostris and Macropodia linaresi. In addition, some information about the spatial and bathymetric distribution as well as biotope preferences of the decapod community is provided.
TREATMENT OUTCOMES OF MULTIDRUG RESISTANT TUBERCULOSIS PATIENTS IN EAST JAVA FROM 2014 TO 2017

Background: Multidrug resistant tuberculosis (MDR TB) is a major public health problem marked by the Mycobacterium tuberculosis strain that is resistant to first line anti TB drugs, including rifampicin and isoniazid simultaneously. A patient confirmed as having MDR TB can transmit this form of TB to other individuals. Therefore, treatment success is the main target when addressing MDR TB. Purpose: This study aimed to assess the treatment outcomes of MDR TB patients in East Java Province from 2014 to 2017. Method: This is a quantitative-descriptive study using the secondary data of drug resistant TB patients sourced from the e-TB Manager website in the East Java Province Health Office. Results: The results show that the average MDR TB patients was 47 years old, 57.44% were male, 37.52% had a negative HIV status, 44.87% were relapse patients, 71.95% had undergone two or less previous treatments, and 69.24% had sputum culture conversion. The treatment outcomes included 161 patients (31.14%) confirmed as cured, 27 patients (5.22%) completing treatment, 174 patients (33.65%) defaulting, two patients (0.38%) confirmed as having failed treatment, and 59 patients (11.41%) dying during the treatment period. Conclusion: The treatment success rate was low and the number of defaults was high. Therefore, it is hoped that there will be support from those closest to the patient and health workers who will maintain and increase the patient's motivation to complete the treatment.
Language Teaching Methodology as a Lived Experience: An Autoethnography from China

Research in language pedagogy often falls into the positivist trap of taking a desirable methodology as the ontological center and evaluating teachers’ teaching against it. Inspired by Snider et al.’s (1992) enactment approach to curriculum development, this article takes language teaching methodology as the lived experiences of students and teachers. From multiple roles and perspectives, the author recollects his personal history with different methodologies in English education in China from the 1980s to 2010s. Through this autoethnographic exploration, the author reflects on the shifting landscape of English education in China through the lens of his pedagogical lived experiences. The article also aims to rectify methodology as a theoretical construct in language education research, arguing that the gap between planned methodology and enacted methodology is the most fruitful space for pedagogical research in language education.
Metalinguistic contribution to reading comprehension: A comparison of Primary 3 students from China and Singapore

Abstract This study examined the within- and cross-language metalinguistic contribution of three components of metalinguistic awareness (i.e., phonological awareness, morphological awareness, and syntactic awareness) to reading comprehension in monolingual Chinese-speaking children from Mainland China (n = 190) and English–Chinese bilingual children from Singapore (n = 390). Moreover, the effect of home language use on the relationship between metalinguistic awareness and reading performance was investigated. For monolingual children, hierarchical regression analyses revealed that after partialing out the effects of age, nonverbal intelligence, and oral vocabulary, syntactic awareness uniquely predicted 7%–13% of the variance in reading comprehension measures, whereas this relationship was not observed between morphological awareness and reading comprehension. For the bilingual children, within-language regression analyses revealed that English/Chinese morphological awareness and syntactic awareness both contributed significantly to English/Chinese reading measures over and above vocabulary and phonological awareness. Cross-linguistically, structure equation modeling results demonstrated that the bilingual children’s English and Chinese metalinguistic awareness were closely related and jointly supported reading comprehension in both languages, thus lending support to Koda’s transfer facilitation model. Furthermore, home language use was found to contribute to the bilingual children’s reading proficiency via its impact on metalinguistic awareness. The paper concludes with a discussion of the policy and pedagogical implications that can be drawn from these findings.
The importance of spatial scale in habitat selection by European beaver

187 –––––––––––––––––––––––––––––––––––––––– © 2018 The Authors. This is an Online Open article This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Subject Editor: Douglas A. Kelt Editor-in-Chief: Jens-Christian Svenning Accepted 8 August 2018 42: 187–200, 2019 doi: 10.1111/ecog.03621 doi: 10.1111/ecog.03621 42 187–200
Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses

α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein accumulation occurs at presynapses where the protein is normally localized. While it is generally agreed that excess α-synuclein impairs synaptic vesicle trafficking, the underlying mechanisms are unknown. Abstract α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein accumulation occurs at presynapses where the protein is normally localized. While it is generally agreed that excess α-synuclein impairs synaptic vesicle trafficking, the underlying mechanisms are unknown. We show here that acute introduction of excess human α-synuclein at a classic vertebrate synapse, the lamprey reticulospinal (RS) synapse, selectively impaired the uncoating of clathrin-coated vesicles (CCVs) during synaptic vesicle recycling, leading to an increase in endocytic intermediates and a severe depletion of synaptic vesicles. Furthermore, human α-synuclein and lamprey γ-synuclein both interact in vitro with Hsc70, the chaperone protein that uncoats CCVs at synapses. After introducing excess α-synuclein, Hsc70 availability was reduced at stimulated synapses, suggesting Hsc70 sequestration as a possible mechanism underlying the synaptic vesicle trafficking defects. In support of this hypothesis, increasing the levels of exogenous Hsc70 along with α-synuclein ameliorated the CCV uncoating and vesicle recycling defects. These experiments identify a reduction in Hsc70 availability at synapses, and consequently its function, as the mechanism by which α-synuclein induces synaptic vesicle recycling defects. To our knowledge, this is the first report of a viable chaperone-based strategy for reversing the synaptic vesicle trafficking defects associated with excess α-synuclein, which may be of value for improving synaptic function in PD and other synuclein-linked diseases.
POFUT2-mediated O-glycosylation of MIC2 is dispensable for Toxoplasma gondii tachyzoites

Toxoplasma gondii is a ubiquitous obligate intracellular eukaryotic parasite that causes congenital birth defects, disease of the immunocompromised and blindness. Protein glycosylation plays an important role in the infectivity and evasion of immune response of many eukaryotic parasites and is also of great relevance to vaccine design. Here, we demonstrate that MIC2, the motility-associated adhesin of T. gondii, has highly glycosylated thrombospondin repeat domains (TSR). At least seven C-linked and three O-linked glycosylation sites exist within MIC2, with >95% occupancy at O-glycosylation sites. We demonstrate that the addition of O-glycans to MIC2 is mediated by a protein O-fucosyltransferase 2 homologue (TgPOFUT2) encoded by TGGT1_273550. While POFUT2 homologues are important for stabilizing motility associated adhesins and host infection in other apicomplexan parasites, in T. gondii loss of TgPOFUT2 has only a modest impact on MIC2 levels and the wider proteome. Consistent with this, both plaque formation and tachyzoite infectivity are broadly similar in the presence or absence of TgPOFUT2. These findings demonstrate that TgPOFUT2 O-glycosylates MIC2 and that this glycan is dispensable in T. gondii tachyzoites.
Candida Co-Infection with Mycobacterium tuberculosis in Tuberculosis Patients and Antifungal Susceptibility of the Isolates

It had been observed that tuberculosis (TB) subjects can be co-infected with Candida sp. which was previously assumed as normal flora of the oral cavity. Candida sp. might become an opportunistic pathogen in immune compromised individuals. Candida co-infection with Mycobacterium tuberculosis in TB patients might complicate underlying disease process in the lungs. Materials and Methods: A total of 400 sputum samples were collected from TB patients and examined using Ziehl-Neelsen staining technique and MDR/RIF Genexpert system for TB. Samples positive for Mycobacterium tuberculosis were cultured on Sabouraud Dextrose Agar with gentamicin and examined for the presence of budding yeast cells and pseudohyphae on Gram’s stain. Candida sp. isolated from TB positive sputa were cultured on CHROMager Candida for identification to species level and subjected to antifungal susceptibility testing. Results: Out of 400 sputum samples examined for TB 93 (23.3%) were positive and 32 (34.4%) out of 93 TB positive cases were co-infected with Candida sp. Candida albicans was the most predominant species with a prevalence of 23 (67.6%), C. tropicals 4 (11.8%), C. krusei 4 (11.8%) and C. parapsilosis 3 (8.8%). One sample had dual infection. Female subjects had high prevalence (19.4%) than the male (15.7%). Age group 31 - 40 years had both high prevalence of TB 32.3% and Candida 25.0%. Antifungal susceptibility testing showed that isolated Candida sp. were more susceptible to vericonazole and fluconazole compared to nystatin. Conclusions: Tuberculosis weakens the immune systems of infected persons especially when prophylactic administration proves abortive or there is non-adherence to treatment prescriptions. This may cause the development of multidrug resistance TB. Candida sp. may utilize these opportunities to establish alongside M. tuberculosis and worsen treatment and patient condition. For good treatment of TB, Candida co-infection should be screened concomitantly with TB in TB suspected individuals.
Challenges Faced by English Teachers: Implementation of Higher Order Thinking Skills (HOTS) in Designing Assignments in East Indonesia

Higher Order Thinking Skills (HOTS) have been implemented in Indonesia as part of the 21st Century learning to face Industry Revolution 4.0. The implementation of HOTS is also fully supported by the Minister of Education (MoE) considering, that those critical thinking skills are fundamental to facilitate the graduates with problem-solving and decision making. Nevertheless, very limited references discuss English teacher perceptions on the implementation of HOTS in terms of designing assignments for English learning. As HOTS implementation cannot be separated from the teachers’ role, the teachers are supposed to exhibit good skills in designing assignments by integrating HOTS aspects. The research question and objective of this study relate to the following issue: what are the challenges of designing HOTS assignments as perceived by English teachers in East Indonesia? The research participants were twenty Senior High School English teachers in Flores Island, East Nusa Tenggara, Indonesia. The researchers developed our research instruments, namely questionnaire, class observation, Focus Group Discussion (FGD), and interview. The data were subsequently cross-checked with the results from each instrument to triangulate the data consistency. This study indicated that the participants had a positive perception of designing HOTS assignments. However, the participants also faced challenges in its implementation. They were divided into three categories, namely: teachers’ knowledge, teachers’ preparation, and students’ limited ability. These findings also provided the reasons why English teachers need to construct positive awareness on the importance of HOTS in designing assignments to improve the quality of the English learning process.
O Impacto dos Investimentos em P&D no Retorno das Ações: Um Estudo das Companhias de Energia Elétrica Listadas na B3

Em virtude de um cenário global marcado pela competição, em que as empresas têm aprimorado seus produtos e processos com o propósito de permanecerem no mercado e almejando expansão para atender a padrões cada vez mais elevados de exigência dos consumidores, a Pesquisa e Desenvolvimento (P&D) é uma ferramenta eficaz a essas entidades por promover o aperfeiçoamento e a inovação. Posto isso, esta pesquisa objetiva verificar se o investimento em P&D resulta em Value Relevance para o mercado de capitais das empresas do setor de energia elétrica listadas na B3. A análise dos dados foi realizada para o período de 2010 a 2018, utilizando-se de regressão múltipla com os dados em painel por meio do Software Stata 13. Os resultados apontam que os investimentos em P&D realizados por essas entidades não geram conteúdo informacional relevante para influenciar o preço das ações. Uma possível causa para esse resultado pode ser atribuída à incerteza gerada pela atividade de P&D devido às suas limitações em prever a obtenção de benefícios futuros para as entidades.
The first record of amphisbaenian and anguimorph lizards (Reptilia, Squamata) from the upper Miocene Solnechnodolsk locality in Russia

ABSTRACT The amphisbaenian and anguimorph fossil lizards from the late Miocene (MN 13) Solnechnodolsk locality (southern European Russia) are described. Amphisbaenians are represented only by isolated vertebrae of which more precise allocation is difficult. The anguine material shows the presence of at least two taxa which are described from this area for the first time: Anguis cf. rarus and Ophisaurus cf. spinari. The A. rarus was previously known only from the early Miocene of Germany. Ophisaurus spinari has a broad stratigraphic range – from the early and middle Miocene of Central Europe, with the last occurrence documented from the late Pliocene of Italy. However, no record was known from the late Miocene, which would show an important part of the story. The parietal of A. cf. rarus forms the first evidence of its survival to the end of the Miocene by its shifting to south areas of Eastern Europe, together with O. spinari. The Solnechnodolsk material is evidence of a broad spatial and/or temporal distribution of both these anguine taxa and the parietal of Anguis unambiguously documents the presence of this taxon in Russia already in the late Miocene. The thermophilic forms in Solnechnodolsk are represented by monitor lizards (Varanus).
Acute Effects of Self-myofascial Release using a Foam Roller on Arterial Stiffness in Healthy Young Adults

This study aimed to investigate whether a single bout of Self-myofascial Release (SMR) has a beneficial effect on peripheral and central Blood Pressure (BP) and different parameters of arterial stiffness. Twenty nine healthy male recreational athletes (26.1 ± 2.9 years, BMI 23.4 ± 1.5 kg/m 2 ) completed an instructed SMR using a foam roller. Peripheral and central BP and different parameters of arterial stiffness were measured noninvasively before SMR and at different time points (t1, t15, t30) during a subsequent 30-min recovery phase. There was a significant decrease in both systolic (t15, −2.36 ± 4.45 mmHg, p = 0.05; t30, −4.01 ± 4.47 mmHg, p = 0.003) and diastolic (t30, −2.45 ± 5.45 mmHg, p = 0.025) peripheral pressure during the recovery phase after SMR. Regarding central BP, only systolic pressure showed a significant decrease (t30, −3.64 ± 5.83 mmHg, p = 0.003). Mean arterial pressure (t15, −1.91 ± 3.36, p = 0.03; t30, −3.05 ± 2.88 mmHg, p < 0.001), augmentation pressure (t30, −1.60 ± 2.40 mmHg, p = 0.009), peripheral resistance (t30, −0.09 ± 0.10 s * mmHg/ml, p < 0.001), and stiffness index b 0 (t30, −0.33 ± 0.55, p = 0.021) were significantly reduced after SMR. No significant changes were determined for reflection coefficient, augmentation index, cardiac output, and heart rate, respectively. SMR showed effects on peripheral and central BP and different parameters of arterial stiffness in healthy young adults.
Nasal Septum Perforation Associated to Histoplasmosis: A Retrospective Study

Objective: To determine the prevalence of nasal septum perforation associated to Histoplasma sp. Material and Methods: A retrospective descriptive study was conducted with patients who developed nasal septum perforation associated to histoplasmosis. The diagnosis was made based on clinical manifestations and confirmed with mycological direct examination with Giemsa stain, culture, serologic tests (immunodiffusion method), and histopathology with hematoxylin-eosin, Grocott methenamine (GMS) and Periodic Acid-Schiff stain (PAS). Results: Out of 1654 medical records reviewed with diagnosis of histoplasmosis in the study period, we found 22 cases with nasal septum perforation. Autoimmune disease was present in 6 patients; all six were on immunosuppressive treatment. Two patients had HIV/AIDS, one of them had also paracoccidiodomycoses and the remaining had no apparent underlying disease or conditions . Conclusion: Physicians of endemic areas such as Venezuela, must consider this entity in the differential diagnosis with other diseases.
Diversity and distribution of algal settlement in Mangrove of Londji, Kribi-Southern-Cameroon

Objective: Phytosociological characterization of microalgae in the mangrove area of Londji in Kribi, South Region of Cameroon while analysing the physicochemical parameters related to it. Methodology and results: Geo-textiles were laid in the river and water samples taken. One hundred and eight (108) samples were collected in 6 different areas. One hundred and twenty-four (124) species of microalgae were inventoried in this ecosystem, divided into 87 genera, 50 families, 26 orders, 11 classes and 5 groups (phyla). The Bacillariophyceae class was the highest with 59.68%, followed by Xygophyceae 3.23% and Haptophyceae 2.42%. Euglenophyceae and Xanthophyceae both had 1.61% while Chrysophyceae, Rhodophyceae and Cryptophyceae all had 0.81%. Finally, Cyanophyceae represented 5.65% of total number of species. The analyses of the physicochemical parameters did not show major organic pollution however little metallic pollution was observed. Conclusion and application: This work made it possible to set up three aspects of biodiversity: to know the algal diversity of the environment, to inventory different species, and to know the state of the ecological environment of this ecosystem. Thus, to know the state of the environment for the development of this ecosystem, within the framework of the emerging shrimp farming in Cameroon. Keys words: Cameroon, Kribi, mangrove, microalgae, plant sociology. Motto et al., J. Appl. Biosci. 2020 Diversity and distribution of algal settlement in Mangrove of Londji, Kribi-
I Do Biotech Dental Implants: Prospective Multicentric Study after 5 Years of Functional Loading

Introduction: I Do Biotech’s implants were developed starting in 2014. Since then, they obtained GMP and KFDA licenses for distribution in 2015. The main objective of this paper is to determine the survival rate of I Do Biotech implants five years after the first surgery. Material and Methods: 1000 implants were used on 480 prostheses across 10 clinics on 320 healthy, non-smoker and non-diabetic patients, chosen at random, of which 160 are male and 160 female, all in the age range of 30 to 50 years old. The failure rate was studied related to the patient’s gender, the length and diameter of the implant, anatomical location, the percentage of peri-implantitis, prosthodontic failures and the patient’s quality of life. Discussion: The results obtained are similar to those of Van Steenberghe D. Dieter-Busenlechner, E. Serrano Catauria and far superior to those of Saenz Guzman. Failure rates vary greatly from study to study due to the heterogeneity of the samples in the other research papers. Conclusion: The overall implant failure rate at 5 years is 1.7%. The factors affecting significantly the survival rate are: the implant diameter, its length and the anatomic area. Failure ratios increase significantly when the diameter or the length of the implant decreases, and when they are placed in the posterior maxilla (up to 4.3%). The rate of peri-implantitis is 5.1%. The prosthodontic failure rate is 2.91%. The improvement in quality of life and satisfaction increases with the years.
Analysis of a clariflocculation process with a photometric dispersion analyser (PDA2000)

In this experimental study the clarification process of the drinking water treatment plant (WTP) of Florence (Italy) has been evaluated. At present, the most common way to optimise the clariflocculation process (best type and dosage of coagulants and mixing conditions) is the jar-test procedure which can give information about the final turbidity, and consequently the process efficiency, after a settling period in a batch procedure at laboratory-scale. An alternative method with a Photometric Dispersion Analyser (PDA2000) was recently introduced at the WTP to provide quick and continuous information (flocculation index, correlated with the flocs size) about the aggregation state of particles during a modified jar-test procedure. The PDA2000 was applied to a real suspension (namely Arno river water) providing useful data for the determination of best type and optimum dosage of coagulants. Furthermore a strong correlation between the removal efficiency of the turbidity and PDA a parameter derived from the PDA 2000 data (defined as the rate of the square root of the flocs size index and the maximum slope of the growing curve) was observed.