Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgery of Patent Ductus Arteriosus in Soavinandriana Hospital: Our Experience

Introduction: The missionaries of Doctors of the World began performing the surgical closures of patent ductus arteriosus in Madagascar in 2004. The Malagasy team has been completely autonomous in surgical closures of an isolated patent ductus arteriosus since 2018. The aim of this study was to report on the Malagasy team's experience in the first 5 years of surgical closure of an isolated patent ductus arteriosus at Soavinandriana Hospital. Methods: This was a retrospective and descriptive study, during the five-year period, from January 2018 to December 2022, performed at the Cardiac surgery unit of Soavinandriana Teaching Hospital, including all children underwent surgical closures of an isolated PDA. Demographic data, birth weight, clinical signs, diagnostic imaging, diameter of the ductus, the surgical waiting time after diagnosis, and hospital left stays were analyzed. Results: A total of 104 children underwent surgery of closures of PDA, including 36 boys (34.62%) and 68 girls (65.38%), giving a sex ratio of 52%. The average age was 29.75 months. Fifteen children were born with low birth weight (14.42%). PDA was symptomatic in 84.65% of patients. The commonest symptoms were recurrent pulmonary infections (51.92%) and failure to thrive (25.96%). The mean age at diagnosis was 18 months. Echocardiography showed pulmonary hypertension in 73.25% of cases. The ductus was large in 97.67% of cases, with a mean diameter of 5.17 mm. Chest X-rays showed cardiomegaly (75%) and increased pulmonary vascularization (39.42%). The mean time to surgery after diagnosis was 7.28 months. All patients underwent left posterolateral thoracotomy with sectioning and suturing of the ductus arteriosus. The average hospital stay was 7.33 days. Conclusion: PDA was the most common symptomatic (83.65%) and large (90.38%). Surgical closures of PDA were satisfied in our practice.
Case Report: Prolonged remission of metastatic cisplatin-refractory nasopharyngeal carcinoma with Pembrolizumab

Background Epstein-Barr virus (EBV)-related nasopharyngeal cancer (NPC) is a common type of cancer in certain areas of the world such as southeast Asia, but is uncommon in Canada. There is currently no reliably effective standard treatment for incurable metastatic EBV-related NPC that progresses after first-line therapy with gemcitabine/cisplatin. Methods With his consent, the health records of a patient with relapsed metastatic EBV-related NPC treated with pembrolizumab immunotherapy were retrospectively reviewed and reported. Case report A male patient presented at age 15 with stage IVA EBV-related NPC. Despite response to initial chemoradiation and adjuvant chemotherapy, the patient experienced metastatic cancer relapse in lymph nodes and bone. There was initial response to gemcitabine/cisplatin chemotherapy, but the cancer progressed after 7 cycles. The patient was then switched to pembrolizumab and had a near complete clinical response after 14 cycles. Serum EBV titers have normalized and CT imaging shows only some healed bone metastasis. Retrospective assessment of tumor CPS PD-L1 was >20. Hypothyroidism developed, possibly due to radiation treatment, but otherwise he did not experience any other immune-mediated toxicities on or following treatment, which lasted in total 2 years with 41 cycles. To date, the patient has been observed off pembrolizumab for over one year and is highly functional without evidence of disease progression. Conclusion This case illustrates the potential benefit of immunotherapy for improving survival and quality of life in selected patients with metastatic EBV-positive cisplatin-refractory NPC.
Atriplex (Atriplex halimus): Distribution, Morphology, Physiological Tolerance to Salinity and Drought: A Review

Atriplex halimus is a halophyte plant that is grown in semi-arid and arid regions due to its high capacity to grow in high salinity and drought conditions. The objective of this paper is to review the physiological and morphological changes of A. halimus under different conditions of salinity and drought conditions, as well as compare the different results that are concerned with this plant in the different areas where this plant exists. The result of this review has shown that A. halimus adapt to different saline conditions by creating the balance of the vegetative growth as well as changing the leaves physiology to adapt to the drought conditions by decreasing the water content which Na creates the osmotic adjustment. The A. halimus can reduce/or increase the photosynthesis process depending on the level of drought and salinity conditions. The accumulation of Na increased in the plant as the soil salinity increased. The review has shown that A. halimus increase the uptake of heavy metals if it has high concentrations in soil. The review results show that the different morphological and physiological changes of A. halimus differ from one area to another depending on the drought conditions and soil salinity concentrations. The results showed that A. halimus can be used to rehabilitate deserts that suffer high salinity and drought. Moreover, it can be used to treat the soil contaminated with heavy metals.
Early Ordovician Dounans Limestone fauna, Highland Border Complex, Scotland

ABSTRACT A diverse, but sparsely distributed silicified fauna of over 30 taxa has been recovered from 7·5 tonnes of acid-etched Lower Ordovician Dounans Limestone from the Highland Border Complex, near Aberfoyle. The 13 trilobite taxa obtained include 3 new formally named species: Distazeris adoceta, Punka aetholiciocorus and Ischyrotoma stubblefieldi. Other elements, representing Carolinites, Illaenus, Goniotelina, Sycophantia, Kawina, Heliomeroides, Strotactinus, Ectenonotus, Ceratocephala and an indeterminate bathyurelline are described under open nomenclature although at least 4 are also probably new and 2 more may be conspecific with previously described species. The brachiopods include representatives of Archaeorthis, Nothorthis, Orthidium, ? Camerella, Idiostrophia, Orthambonites and 4 other indeterminate stocks. Gastropods tentatively assigned to Murchisonia, Subulites, Straparollina, Maclurites and Cyrtodiscus are described, as are bryozoans, an orthocone, crinoids, and Incertae sedis. This profoundly North American fauna is Late Canadian ( = mid Arenig) in age and equates with the Cassinian Stage: it is key evidence in showing that the Highland Border rocks are not part of the Dalradian Supergroup whose earliest deformations and metamorphism predate the Ordovician. The field relationships of the limestone, together with evidence from derived clasts in Middle Ordovician and Devonian sequences near Girvan in SW Scotland and at Stonehaven in eastern Scotland suggest that it forms part of a widespread sub-Old Red Sandstone carbonate sequence of Early Ordovician age beneath the northern Midland Valley.
Online Counseling through the Eyes of University Students

This study examined university students' knowledge levels, experiences, opinions, preferences, and suggestions for improving online psychological counseling services with a phenomenological qualitative research design. The data were collected in two stages using the Online Counseling Interview Form (OCIF) developed by the researchers. In the pre-COVID-19 period, researchers interviewed ten university students, and during COVID-19, they reached out to 11 more students. Descriptive analysis showed that students' knowledge levels and experiences increased, and most students were eager to use online counseling services. Moreover, students provided worth-stressing information about their preferences and suggestions regarding the announcement, design, and implementation of online counseling to improve online counseling services in universities.
Evaluation of Corporate Sustainability Strategies and Practices in this Area in the Opinion of Employees – A Comparative Analysis in Poland and India

: Purpose: The purpose of the study was to identify and analyze the opiniions of employees regarding the existence of a sustainability strategy in their companies, included in the long-term strategy of the company, with specific indicators describing the results, in relation to the practices used, based on the experience in Poland and India. In particular, the research conducted was aimed at finding answers to the research problems posed, which took the form of the following questions: Q1. In the opinion of employees, is there a sustainability strategy in the companies, included in the long-term strategy of the company, with specified indicators describing the results? Q2. In this regard, are there differences in the opinions of employees from the point of view of various criteria such as country of origin, gender, age, education, place of residence, job position, size of the company and type of business? Q3. Is there a statistically significant relationship between the employees' evaluation of the existence of a sustainability strategy and their assessment of the degree of sustainability of the company's operations, their sense of trust in their employer and their perception of the benefits after the implementation of sustainable changes in the company. Design/Methodology/Approach: The method of analysis and criticism of the literature, the method of diagnostic survey and statistical methods were used to verify the theses and answer the research questions. A quantitative-qualitative study was conducted, based on a survey questionnaire among 449 employees of companies in Poland and India. Non-parametric tests were used to analyze the data. The results of the responses given on the rank scales according to the grouping variables were analyzed using the Mann-Whitney U test, and the Kruskal-Wallis ANOVA test. The existence of a trend for consecutive populations was measured by the Jonckheere-Terpstra test. Associations between variables were
Jointly Active and Passive Beamforming Designs for IRS-Empowered WPCN

This article studies an intelligent reflecting surface (IRS)-empowered wireless-powered communication network (WPCN) in Internet of Things (IoT) networks. In particular, a power station (PS) with multiple antennas uses energy beamforming to enable wireless charging to multiple IoT devices, in the downlink wireless energy transfer (WET) phase; then, during the uplink wireless information transfer (WIT) phase, these IoT devices utilize the harvested energy to concurrently transmit their individual information signal to a multiantenna access point (AP), which equips with multiuser decomposition (MUD) techniques to reconstruct the IoT devices’ signal. An IRS is deployed to improve the energy collection and information transmission capabilities in the WET and WIT phases, respectively. To examine the performance of the system under study, we maximize the sum throughput with the aim of jointly designing the optimal solutions for the active PS energy beamforming, AP receive beamforming, passive IRS beamforming, and time scheduling. Due to the multiple coupled variables, the resulting formulation is nonconvex, and a two-level scheme to solve the problem is proposed. At the outer level, a 1-D search method is applied to find the optimal time scheduling, while at the inner level, an iterative block coordinate descent (BCD) algorithm is proposed to design the optimal receive beamforming, energy beamforming, and IRS phase shifts. In particular, the receive beamforming part is designed by considering the equivalence between sum rate maximization and sum mean square error (MSE) minimization, thereby deriving a closed-form solution. Furthermore, we alternately optimize the energy beamforming and IRS phase shifts using Lagrange dual transformation (LDT), quadratic transformation (QT), and alternating direction method of multipliers (ADMMs) methods. Finally, numerical results are presented to showcase the performance of the proposed solution and highlight its advantages compared to some typical benchmark schemes.
Marine biodiversity through the Late Cenomanian–Early Turonian: palaeoceanographic controls and sequence stratigraphic biases

Changes in the marine macro- and microfauna, sedimentary geochemistry and surface-water palaeoproductivity through the last 500 000 years of the Cenomanian and first 300 000 years of the Turonian are documented. These are based on the succession at Eastbourne, the thickest and most complete section through the Late Cenomanian and Early Turonian in the Anglo–Paris Basin. Two levels of rapid faunal and geochemical change are identified, one coincident with a significant increase in siliciclastic input at the base of the Plenus Marls Member, and the other with a marked drop in surface water productivity near the top of the same unit. Faunal change is demonstrated to be largely a pattern of immigration–emigration rather than true extinction, and our sequence stratigraphical analysis shows that it was coincident with major sea-level changes. No evidence is found to support the hypothesis that reduced bottom water oxygenation developed and was responsible for extinctions amongst the benthos in mid-shelf environments. The onset of pure chalk facies is interpreted to mark the breakdown of shelf-break fronts and the spread of oligotrophic oceanic waters over much of the continental shelf, initiated by rising sea-level. The Cenomanian–Turonian event, far from recording a mass extinction of shelf fauna, is most probably an artifact caused by a significant switch in the nature of the surviving sedimentary record as a result of a major, but perfectly ordinary, oceanographic change.
The Relationship between Convection and Sea Surface Temperature on Intraseasonal Timescales

Abstract The relationship between tropical convection, surface fluxes, and sea surface temperature (SST) on intraseasonal timescales has been examined as part of an investigation of the possibility that the intraseasonal oscillation is a coupled atmosphere–ocean phenomenon. The unique feature of this study is that 15 yr of data and the whole region from the Indian Ocean to the Pacific Ocean have been analyzed using lag-correlation analysis and compositing techniques. A coherent relationship between convection, surface fluxes, and SST has been found on intraseasonal timescales in the Indian Ocean, Maritime Continent, and west Pacific regions of the Tropics. Prior to the maximum in convection, there are positive shortwave and latent heat flux anomalies into the surface, followed by warm SST anomalies about 10 days before the convective maximum. Coincident with the convective maximum, there is a minimum in the shortwave flux, followed by a cooling due to increased evaporation associated with enhanced westerl.
Issues of Global and Local Quality in Arts Education Aspectos de la Calidad Global y Local en la Educación Artística Questions de qualité globale et locale dans les arts

Quality is not a random occurrence in arts and creativity partnerships. The achievement of quality must be planned. Any arts partnership requires both quality assurance and quality control components. Quality assurance manages quality of processes, while quality control measures deliverables — ‘products’ — against standards. This paper looks at quality from a global and local perspective and argues that arts experiences from children and young people need to be:
A REVIEW OF STUDIES OF FISHING GEAR SELECTIVITY IN THE MEDITERRANEAN

The selectivity parameters of four cod-ends, varying in mesh size and meshes round the circumference were measured using the covered cod-end technique on a typical Italian commercial trawl in the Adriatic Sea. The mesh sizes tested were 24 and 28 mm bar length and the nominal circumferences were 6.7 and 7.8 m. The cover mesh bar length was 10 mm. Measurements were made in 1998 at a depth of 16 m and in 1999 at depths of 130 to 250 m. In 1998, selectivity data were obtained on red mullet (Mullus barbatus), common pandora (pagellus erythrinus), squid (Loligo vulgaris) and cuttlefish (Sepia officinalis). In 1999, selectivity data were obtained on hake (Merluccius merluccius), blue whiting (Micromesistius poutassou), poor cod (Trisopterus minutus capelanus), Norway lobster (Nephrops norvegicus), red mullet (Mullus barbatus) and broadtail squid (Illex coindetti). In some hauls red mullet and hake dominated the catch. The 50% retention lengths were significantly different between test cod-ends and confidence limits were obtained for the parameters.
Furongian (upper Cambrian) Guole Konservat‐Lagerstätte from South China

The Guole biota contains common shelly fossils and some exceptionally well‐preserved soft‐bodied fossils. Stratigraphically, it is located in the mudstones and siltstones of the Sandu Formation near Guole Town, Jingxi County, Guangxi, South China. It is the first Furongian (late Cambrian) Burgess Shale‐type biota found in the world, thereby filling the gap between middle Cambrian and Lower Ordovician Burgess Shale‐type Lagerstätten. Preliminary studies suggest that the Guole biota includes approximately seven metazoan groups as well as algae. These will provide important new evolutionary and ecological information.
The efficacy of a computer science curriculum for early childhood: evidence from a randomized controlled trial in K-2 classrooms

Background and context: Despite the growing importance of computer science (CS) education, high-quality CS curricula for students in kindergarten to lower elementary grades are lacking. It is also unclear how students from underrepresented groups such as female students, students from low socioeconomic status, and students with disability respond to CS curriculum at this age range. Objective: This study is aimed to examine the effectiveness of a novel CS curriculum (Coding as Another Language – ScratchJr) on the development of programming and computational thinking skills for students in kindergarten to second grade classrooms. Method: We conducted a randomized controlled trial with 1057 students and used multilevel regression analysis to examine the impact of the CAL curriculum on students’ coding and computational thinking skills, as well as moderation analysis to investigate how students’ demographic characteristics including gender, socio-economic status, English learners and disability interacted with the intervention effectiveness. Findings: The CAL curriculum was effective in improving students’ programming skills, but no significant differences were detected for students’ computational thinking skills. Students with limited English proficiency and students from low socioeconomic backgrounds achieved similar gain in coding skills but students with disabilities and female students did not demonstrate the same improvements as their peers. Implications: These findings shed light on the educational efficacy of CAL as a promising CS curriculum for young children and under-score the importance of understanding how underrepresented minority students respond to the curriculum in order to better guide the development and design of the CS programs.
Soft-Error-Aware SRAM With Multinode Upset Tolerance for Aerospace Applications

As technology scales down, the critical charge (QC) of vulnerable nodes decreases, making SRAM cells more susceptible to soft errors in the aerospace industry. This article proposes a Soft-Error-Aware 16T (S8P8N) SRAM cell for aerospace applications to address this issue. The properties of S8P8N are evaluated and compared with 6T, DICE, QUCCE12T, WEQUATRO, RHBD10T, RHBD12T, S4P8N, SEA14T, and SRRD12T. Simulation results indicate that all vulnerable nodes and key node pairs of the proposed cell can recover to their original states when affected by a soft error. Additionally, it can recover from key multinode upsets. The write speed of the proposed cell is found to be reduced by 20.3%, 50.1%, 74.1%, 63.7%, and 50.41% compared to 6T, DICE, QUCCE12T, WEQUATRO, and RHBD10T, respectively. The read speed of the proposed cell is found to be reduced by 56.6%, 52.2%, 62.5%, and 35.2% compared to 6T, SRRD12T, RHBD12T, and S4P8N, respectively. It also shows that the hold power of the proposed cell is found to be reduced by 14.1%, 13.8%, 17.7%, and 23.4% compared to DICE, WEQUATRO, RHBD10T, and RHBD12T. Furthermore, the read static noise margin (RSNM) of the proposed cell is found to be enhanced by 157%, 67%, and 32% compared to RHBD12T, SEA14T, and SRRD12T. All these improvements are achieved with a slight area penalty.
The East Greenland Caledonides—teleseismic signature, gravity and isostasy

S U M M A R Y The large-scale geological evolution of the North Atlantic Realm during the past 450 Myr is largely understood, but crucial elements remain uncertain. These involve the Caledonian orogeny, the formation of the North Atlantic and accompanying igneous activity, and the present-day high topography surrounding the North Atlantic. Teleseismic receiver function interpretation in the Central Fjord Region of East Greenland recently suggested the presence of a fossil Caledonian subduction complex, including a slab of eclogitised mafic crust and an overlying wedge of serpentinised mantle peridotite. Here we further investigate this topic using inverse receiver functions modelling. The obtained velocity models are tested with regard to their consistency with the regional gravity field and topography. We find that the obtained receiver function model is generally consistent with gravity and isostasy. The western part of the section, with topography of >1000 m, is clearly supported by the 40-km-thick crust. The eastern part requires additional buoyancy as provided by the hydrated mantle wedge. The geometry, velocities and densities are consistent with interpretation of the lithospheric structure as a fossil subduction zone complex. The spatial relations with Caledonian structures suggest a Caledonian origin. The results indicate that topography is isostatically compensated by density variations within the lithosphere, and that significant dynamic topography is not required at the present-day.
Kinesin Family Member C1 (KIFC1/HSET) Underlies Aggressive Disease in Androgen Receptor-Low and Basal-Like Triple-Negative Breast Cancers

Quadruple-negative breast cancer (QNBC) lacks traditional actionable targets, including androgen receptor (AR). QNBC disproportionately afflicts and impacts patients of African genetic ancestry. Kinesin family member C1 (KIFC1/HSET), a centrosome clustering protein that prevents cancer cells from undergoing centrosome-amplification-induced apoptosis, has been reported to be upregulated in TNBCs and African-American (AA) TNBCs. Herein, we analyzed KIFC1 RNA levels and their associations with clinical features and outcomes among AR-low and AR-high TNBC tumors in three distinct publicly available gene expression datasets and in the breast cancer gene expression database (bc-GenExMiner). KIFC1 levels were significantly higher in AR-low and basal-like TNBCs than in AR-high and non-basal-like TNBCs, irrespective of the stage, grade, tumor size, and lymph node status. KIFC1 levels were also upregulated in AR-low tumors relative to AR-high tumors among Black and premenopausal women with TNBC. High KIFC1 levels conferred significantly shorter overall survival, disease-free survival, and distant metastasis-free survival among AR-low and basal-like TNBC patients in Kaplan–Meier analyses. In conclusion, KIFC1 levels may be upregulated in AR-low tumors and, specifically, in those of African descent, wherein it may promote poor outcomes. KIFC1 may be an actionable cancer-cell-specific target for the AR-low TNBC subpopulation and could aid in alleviating racial disparities in TNBC outcomes.