Miracle-dz/UniFAR-FTUs huggingface dataset:
Joint Power Spectrum and Voxel Intensity Distribution Forecast on the CO Luminosity Function with COMAP

We develop a framework for joint constraints on the CO luminosity function based on power spectra (PS) and voxel intensity distributions (VID) and apply this to simulations of CO Mapping Array Pathfinder (COMAP), a CO intensity mapping experiment. This Bayesian framework is based on a Markov chain Monte Carlo (MCMC) sampler coupled to a Gaussian likelihood with a joint PS + VID covariance matrix computed from a large number of fiducial simulations and re-calibrated with a small number of simulations per MCMC step. The simulations are based on dark matter halos from fast peak patch simulations combined with the LCO(Mhalo) model of Li et al. We find that the relative power to constrain the CO luminosity function depends on the luminosity range of interest. In particular, the VID is more sensitive at large luminosities, while the PS and the VID are both competitive at small and intermediate luminosities. The joint analysis is superior to using either observable separately. When averaging over CO luminosities ranging between , and over 10 cosmological realizations of COMAP Phase 2, the uncertainties (in dex) are larger by 58% and 30% for the PS and VID, respectively, when compared to the joint analysis (PS + VID). This method is generally applicable to any other random field, with a complicated likelihood, as long a fast simulation procedure is available.
Homelessness and incarceration associated with relapse into stimulant and opioid use among youth who are street‐involved in Vancouver, Canada

INTRODUCTION AND AIMS While much research has sought to identify the factors associated with initiation and cessation of various forms of drug use among vulnerable youth, little is known about relapse into drug use in this population. We sought to characterise relapse into stimulant and opioid use among street-involved youth in Vancouver, Canada. DESIGN AND METHODS Data were collected between 2005 and 2017 from the At-Risk Youth Study, a prospective cohort study of street-involved youth who use illicit drugs in Vancouver. Multivariable extended Cox regression was utilised to identify factors associated with relapse into illegal stimulants and/or opioids among youth who had previously ceased using stimulants and/or opioids for 6 months or longer. RESULTS Among 246 participants who reported a period of cessation lasting 6 months or longer, 165 (67.1%) relapsed at some point during study follow-up. Youth who were recently incarcerated (adjusted hazard ratio [AHR]: 1.46), homeless (AHR: 1.43), or had a history of daily stimulant use (AHR: 1.48) were significantly more likely to report relapse, while youth of who identified as white (AHR: 0.74) were significantly less likely to report relapse (all P < 0.05). DISCUSSION AND CONCLUSIONS Relapse into stimulants and/or opioids was common among youth in our setting, and incarceration, homelessness, and daily stimulant use were found to be positively associated with relapse among youth. Findings suggest that increased access to youth housing supports and alternatives to the criminalisation of drug use may help to reduce the rates of relapse into stimulants and/or opioids in this population.
The emerging role of leptin, Adiponectin and Visfatin in Ischemic/Hemorrhagic stroke

Abstract Introduction: Adipose tissue acts as an active endocrine organ and may be involved in the biological mechanism of stroke. Adipokines can serve as key messenger of central energy and metabolic homeostasis and can contribute to the crosstalk between adipose tissue and brain. Recent research has offered vague data on the relationships between adipose tissue, adipokines, and vascular disorders. We aimed to investigate the clinical significance of serum leptin, adiponectin and visfatin levels and functional outcomes in patients with ischemic and hemorrhagic cerebrovascular diseases. Methods: Thirty-five patients with acurte intracerebral haemorrhage (ICH), 35 patients with acute ischemic stroke and 18 age- and sex-matched healthy controls were recruited. A sandwich ELISA was developed to measure the presence of serum adiponectin, leptin and visfatin levels. Results: Serum total cholesterol, low density lipoprotein, leptin, visfatin levels and systolic and diastolic blood pressure were higher and serum adiponectin levels were lower in patients at admission compared with healthy volunteers. Conclusion: According to the novel study, it was suggested that elevated serum leptin as well as visfatin and decreased adiponectin levels may be a sign of cerebrovascular disease and as part of the response occurring in stroke patients.
CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 6: A Key Regulator of Na+ Homeostasis during Germination1[OPEN]

The transcription factor CAMTA6 substantially affects the transcriptome of salt-stressed germinating seeds, including genes encoding Na+ transporters, such as AtHKT1, to maintain Na+ homeostasis. Salinity impairs seed germination and seedling establishment. We investigated the role of Arabidopsis (Arabidopsis thaliana) CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 6 (CAMTA6) in salinity stress responses during early germination. Compared with the wild type, the camta6-4 and camta6-5 mutants were more tolerant to NaCl and abscisic acid (ABA) and accumulated less Na+. In contrast, 4- to 11-d-old camta6 seedlings were more sensitive to NaCl. In camta6, expression of HIGH-AFFINITY K+ TRANSPORTER1 (AtHKT1;1), encoding an Na+/K+ transporter, was restricted to the radicles and was not enhanced by NaCl or ABA. During germination, the camta6 hkt1 double mutant was as sensitive as the wild type and hkt1 to NaCl, suggesting that HKT1;1 is crucial for the salt tolerance of camta6. An ABA response element in the HKT1;1 promoter was found to be indispensable for the enhanced expression of the gene in response to NaCl and to ABA. Transcriptome analysis of the wild type and camta6-5 with and without salt treatment revealed 1,020 up-regulated and 1,467 down-regulated salt-responsive genes in the wild type. Among these, 638 up-regulated and 1,242 down-regulated genes were classified as CAMTA6-dependent. Expression of several known salt stress-associated genes, including SALT OVERLY SENSITIVE1 and Na+/H+ ANTIPORTER, was impaired in camta6 mutants. Bioinformatics analysis of the 5′ upstream sequences of the salt-responsive CAMTA6-dependent up-regulated genes revealed the CACGTGTC motif as the most prominent element, representing an ABA response element and a potential CAMTA-binding site. We suggest that CAMTA6 regulates, directly or indirectly, the expression of most of the salt-responsive genes in germinating seeds, including genes that are crucial for Na+ homeostasis and salt stress tolerance.
Prelamin A overexpression promotes detrusor calcification/aging in urinary incontinence via prelamin A accumulation

Urinary incontinence (UI) is known as a distressing condition particularly among older adults, and negatively associated with health‐related quality of life in both males and females. Prelamin A accumulation has been found in all progeroid laminopathies and is obviously linked to cell and organism aging. Therefore, this study was expected to investigate the effect of prelamin A on detrusor on UI. Prelamin A expression in clinical and animal samples was detected. To investigate the degree of prelamin A accumulation and detrusor calcification/aging, the detrusor cells were subcultured separately into low and high passage. The low‐passage subculture cells were treated with transfection of overexpressed prelamin A plasmid, and transfection of overexpressed prelamin A plasmid and application of farnesyl transferase inhibitor (FTIs) H‐9279, respectively. Zmpste24, Icmt and lamin A/C expression were detected to explore how prelamin A affected detrusor calcification/aging. Prelamin A was overexpressed in aged detrusor cells, indicating prelamin A expression was positively related to the age of subjects. The degree of prelamin A accumulation and detrusor calcification/aging was higher in aged rats and high passage subculture cells. Zmpste24, Icmt and lamin A/C were poorly expressed in cells transfected with overexpressed prelamin A, as well as cell proliferation activity decreased and calcium deposition and apoptotic rate increased. Furthermore, we also found that the effect of overexpressed prelamin A was lost when cells were treated with H‐9279. These findings provide evidence that prelamin A overexpression impairs degradation of its farnesylated form, thus causing prelamin A accumulation which induces detrusor calcification/aging in UI.
Jaw muscle activity patterns in women with chronic TMD myalgia during standardized clenching and chewing tasks

ABSTRACT Objective: To examine jaw muscle activity of women with chronic temporomandibular myalgia (mTMD). It was hypothesized that mTMD patients had a different masticatory muscle activity, increased work during isometric clenching, and a reduced chewing frequency as compared to TMD-free subjects. Methods: The electromyographic (EMG) activity of temporalis anterior (TA) and masseter (MM) of 27 women with mTMD and 18 TMD-free women was recorded during clenching tasks and while chewing. EMG indices comparing the activity of paired jaw muscles were computed. Results: Women with TMD myalgia had greater muscular work than controls (p = 0.025). The activity of TA and MM were similar between right and left sides in both groups. mTMD patients had a greater activity of MM than TA (p = 0.028). No between-groups differences were found in chewing rate. Conclusion: Women with mTMD showed an abnormal recruitment of the jaw-closing muscles during functional tasks, which may predispose to further tissue injury.
A novel upper-limb function measure derived from finger-worn sensor data collected in a free-living setting

The use of wrist-worn accelerometers has recently gained tremendous interest among researchers and clinicians as an objective tool to quantify real-world use of the upper limbs during the performance of activities of daily living (ADLs). However, wrist-worn accelerometers have shown a number of limitations that hinder their adoption in the clinic. Among others, the inability of wrist-worn accelerometers to capture hand and finger movements is particularly relevant to monitoring the performance of ADLs. This study investigates the use of finger-worn accelerometers to capture both gross arm and fine hand movements for the assessment of real-world upper-limb use. A system of finger-worn accelerometers was utilized to monitor eighteen neurologically intact young adults while performing nine motor tasks in a laboratory setting. The system was also used to monitor eighteen subjects during the day time of a day in a free-living setting. A novel measure of real-world upper-limb function—comparing the duration of activities of the two limbs—was derived to identify which upper limb subjects predominantly used to perform ADLs. Two validated handedness self-reports, namely the Waterloo Handedness Questionnaire and the Fazio Laterality Inventory, were collected to assess convergent validity. The analysis of the data recorded in the laboratory showed that the proposed measure of upper-limb function is suitable to accurately detect unilateral vs. bilateral use of the upper limbs, including both gross arm movements and fine hand movements. When applied to recordings collected in a free-living setting, the proposed measure showed high correlation with self-reported handedness indices (i.e., ρ = 0.78 with the Waterloo Handedness Questionnaire scores and ρ = 0.77 with the Fazio Laterality Inventory scores). The results herein presented establish face and convergent validity of the proposed measure of real-world upper-limb function derived using data collected by means of finger-worn accelerometers.
Environmental Justice in Industrially Contaminated Sites. A Review of Scientific Evidence in the WHO European Region

In the WHO European Region the topic of contaminated sites is considered a priority among environment and health themes. Communities living in or close to contaminated sites tend to be characterized by a high prevalence of ethnic minorities and by an unfavorable socioeconomic status so rising issues of environmental justice. A structured review was undertaken to describe the contents of original scientific studies analyzing distributive and procedural justice in industrially contaminated sites carried out in the WHO European Region in the period 2010–2017. A systematic search of the literature was performed. In total, 14 articles were identified. Wherever assessments on environmental inequalities were carried out, an overburden of socioeconomic deprivation or vulnerability, with very few exemptions, was observed. The combined effects of environmental and socioeconomic pressures on health were rarely addressed. Results show that the studies on environmental and health inequalities and mechanisms of their generation in areas affected by industrially contaminated sites in the WHO European Region are in their early stages, with exemption of UK. Future efforts should be directed to improve study strategies with national and local assessments in order to provide evidence for equity-oriented interventions to reduce environmental exposure and related health risks caused by industrial contamination.
Two decades of research on autoimmune liver disease in Turkey.

BACKGROUND/AIMS Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are the 3 main autoimmune liver diseases (AILDs). The epidemiology of AILD in Turkey is not known. To determine the scientific status, we performed a scientometric analysis of AILD-related original articles that originated from Turkey. MATERIALS AND METHODS We searched the Web of Science database, the Science Citation Index Expanded (SCI-E), and the Social Sciences Citation Index (SSCI) by using the keywords "autoimmune hepatitis," "primary biliary cholangitis/primary biliary cirrhosis," and "primary sclerosing cholangitis" in conjunction with "Turkey. " A scientometric analysis was done on the search results. RESULTS We identified 117 AILD-related papers that were published in Turkey from 1997 to 2019. Among these, 70 case reports, letters, and reviews and 2 original articles that were not cited in SCI-E/SSCI were excluded. The remaining 45 original articles were further analyzed. These studies were related to AIH (n=22), PBC (n=7), PSC (n=9), PBC-AIH overlap (n=5), and others (n=2). Four of the publications originated in pediatric settings; 9 of 45 papers were published from 1997 to 2008 and 36 papers were published from 2009 to 2019. Most papers (75%) were reported from 5 centers; 9 papers (20%) were published in journals with an impact factor of 3 or higher. CONCLUSION The overall number and quality of AILD-related papers in Turkey are unexpectedly low, although a number of papers have received considerable international recognition. More epidemiologic, prospective, and multicenter research projects are warranted to advance AILD knowledge and to produce high-quality research from Turkey.
Prescribing trends and safety of clozapine in an older persons mental health population

ABSTRACT Objectives: To provide additional data concerning the safety, effectiveness and local prescribing trends of clozapine in elderly patients. Design: Retrospective observational case-series analysis. Setting: Data were collected from the medical files of 167 patients prescribed clozapine. Participants: All patients prescribed clozapine in the last 15 years by the psychogeriatric service in Christchurch, New Zealand. The subjects were mostly aged over 65; however, patients under 65 are also accepted into the service on a case by case basis if they have an age-related health condition. Results: Twenty-five (15.0%) patients had their clozapine stopped due to a significant adverse reaction, including eleven who developed significant neutropenia. Seventy-four (44.3%) of the patients had no recorded side effects at all. Sixty-five (38.9%) of our elderly patients died while taking clozapine, though none of these deaths was felt to be related to clozapine use. Several patients safely initiated clozapine in either their own home or a nursing home without requiring hospital admission. Only two patients ceased clozapine due to ineffectiveness, and one hundred, forty-two (86.1%) of the patients had positive comments in their medical record regarding the benefits of clozapine for their particular case. Conclusions: We found clozapine could be used safely and effectively in our patient group, for a wider range of indications and at lower doses than younger patients. Data collection regarding cause of death in elderly patients who were ever prescribed clozapine was problematic, and more research into this area is required.
How Consumers Engage in & Utilize the Source of Electronic Word-of-Mouth (e-WOM)?

This research aims to determine how people are engaging in and utilizing the source of electronic word-of-mouth (e-WOM). The total sample of this research is 667 respondents. As a research method, this study aims to measure the participants’ use and opinions of online reviews (e-WOM) with relation to the following categories: information seeking; general credibility; information processing; susceptibility to online product reviews; and transmission of online product reviews. The result of this research shows that many people visit online review sites before purchasing a product and seek more e-WOM when purchasing expensive products. However, unlike the previous research where consumers utilize e-WOM due to credibility of information, the personal experiences and opinions of the people around them can be more important factors in influencing their purchasing decisions than e-WOM. This result affirms that consumers choose what they think are the right products and brands with the help of e-WOM when dealing with ultimate purchase intentions.
Composition Changes of Inclusions by Reaction with Slag and Refractory: A Review

Precise control on inclusions is of great importance for improving steel quality. In secondary refining, three types of inclusion are generally observed in Al-killed steel: Al 2 O 3 , MgO·Al 2 O 3 spinel, and CaO–Al 2 O 3 type. Many researchers have reported on inclusions transformed in the routine of Al 2 O 3 → MgO·Al 2 O 3 spinel → CaO–Al 2 O 3 during secondary refining in Al-killed steel. The deoxidizer of Al is intentionally added to the steel, and Al 2 O 3 inclusions are formed as a deoxidation product. However, MgO·Al 2 O 3 spinel and CaO–Al 2 O 3 -type inclusions have been observed even without any intentional Mg or Ca addition. Therefore, it is important to clarify the source of Mg and Ca causing MA spinel and CaO–Al 2 O 3 -type inclusions formation, in order to control the compositions of the inclusions. Regarding to this phenomenon, a good review was published by Park and Todoroki in 2010. Several studies have since been conducted. This paper summarized the research activities on the composition changes of inclusions during secondary refining from the aspect of thermodynamics and kinetics.
Safety, Tolerability, and Nocebo Phenomena During Transcranial Magnetic Stimulation: A Systematic Review and Meta‐Analysis of Placebo‐Controlled Clinical Trials

The methodology used for the application of repetitive transcranial magnetic stimulation (TMS) is such that it may induce a placebo effect. Respectively, adverse events (AEs) can occur when using a placebo, a phenomenon called nocebo. The primary aim of our meta‐analysis is to establish the nocebo phenomena during TMS. Safety and tolerability of TMS were also studied.
Modelling Diffusion through Statistical Network Analysis: A Simulation Study

The study of international relations by definition deals with interdependencies among countries. One form of interdependence between countries is the diffusion of country-level features, such as policies, political regimes, or conflict. In these studies, the outcome variable tends to be categorical, and the primary concern is the clustering of the outcome variable among connected countries. Statistically, such clustering is studied with spatial econometric models. This paper instead proposes the use of a statistical network approach to model diffusion with a binary outcome variable. Using statistical network instead of spatial econometric models allows for a more natural specification of the diffusion process, assuming autocorrelation in the outcomes rather than the corresponding latent variable, and it simplifies the inclusion of temporal dynamics, higher level interdependencies and interactions between network ties and country-level features. In our simulations, the performance of the Stochastic Actor-Oriented Model (SAOM) estimator is evaluated. Our simulation results show that spatial parameters and coefficients on additional covariates in a static binary spatial autoregressive model are accurately recovered when using SAOM, albeit on a different scale. To demonstrate the use of this model, the paper applies the model to the international diffusion of same-sex marriage.
Multi LC-MS/MS and LC-HRMS Methods for Determination of 24 Mycotoxins including Major Phase I and II Biomarker Metabolites in Biological Matrices from Pigs and Broiler Chickens

A reliable and practical multi-method was developed for the quantification of mycotoxins in plasma, urine, and feces of pigs, and plasma and excreta of broiler chickens using liquid chromatography–tandem mass spectrometry. The targeted mycotoxins belong to the regulated groups, i.e., aflatoxins, ochratoxin A and Fusarium mycotoxins, and to two groups of emerging mycotoxins, i.e., Alternaria mycotoxins and enniatins. In addition, the developed method was transferred to a LC-high resolution mass spectrometry instrument to qualitatively determine phase I and II metabolites, for which analytical standards are not always commercially available. Sample preparation of plasma was simple and generic and was accomplished by precipitation of proteins alone (pig) or in combination with removal of phospholipids (chicken). A more intensive sample clean-up of the other matrices was needed and consisted of a pH-dependent liquid–liquid extraction (LLE) using ethyl acetate (pig urine), methanol/ethyl acetate/formic acid (75/24/1, v/v/v) (pig feces) or acetonitrile (chicken excreta). For the extraction of pig feces, additionally a combination of LLE using acetone and filtration of the supernatant on a HybridSPE-phospholipid cartridge was applied. The LC-MS/MS method was in-house validated according to guidelines defined by the European and international community. Finally, the multi-methods were successfully applied in a specific toxicokinetic study and a screening study to monitor the exposure of individual animals.