Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimal Portfolio Selection Based On Jordanian Infrastructure Sub-Index Returns

Industry professional and institutional investors want to understand return behaviour and portfolio attributes of infrastructure investment. However, there are limited empirical analyses that support these investments. The scarcity of infrastructure research motivates this study to apply finance theory to this investment. In this paper by collecting monthly Jordanian infrastructure sub-index returns over the period from January 2010 to February 2017, the current study addresses two objectives. The first objective is to examine the importance of listed infrastructure sub-index returns by evaluating the investment characteristics as well as performance of various infrastructure sub-indexes in Jordan. Second, this paper investigates the strategy of infrastructure investors. That is, if the investor obtains diversification benefits by investing in a portfolio including various infrastructure subindexes or invests in only a single infrastructure sub-indexes. The results of this study find that Jordanian infrastructure sub-indexes perform differently and provide dissimilarity in monthly returns and volatilities. The current study finds that listed infrastructure sub-indexes are strongly related to general stock market while weakly related to bonds. This study also shows that some infrastructure sub-indexes such as Health Care and Educational Subindexes dominate optimal portfolio selection while others such as Hotels and Transportation Sub-indexes are undesirable. This paper presents a first light of Jordanian infrastructure returns and provides the foundation for the evaluation of infrastructure in other countries.
Lasers and energy‐based devices marketed for vaginal rejuvenation: A cross‐sectional analysis of the MAUDE database

The FDA issued a statement on July 30, 2018, expressing concern over the marketing of lasers and energy‐based devices to promote “vaginal rejuvenation. ” The FDA stated that there is insufficient data to recommend this modality for optimization of sexual function and alleviation of genitourinary syndrome of menopause (GSM)‐related symptoms in postmenopausal or postpartum women. This analysis aims to characterize the mandatory and voluntary reports concerning laser and energy‐based procedures marketed for vaginal rejuvenation.
EU-Russia relations: a theoretical interpretation of Russia’s perception of the European Union

For several decades the European Union was recognised as a major Russian partner, as cooperation with the EU had important political and economic effects on Russia. While these relations were based on common interests in such areas as energy, trade and cross-border cooperation, they also faced serious difficulties because of their different interpretation of values. A traditional explanation of Russia’s attitude to the European Union was based on the theoretical assumptions of the rationalist approach. Neorealists tend to concentrate on the conflicts between the EU and Russia and describe it as a result of their struggle for spheres of influence over their common neighbourhood. In contrast, Neoliberals focused on EU-Russia cooperation and explained it as a problemsolving mechanism based on common interests and the necessity to solve common problems. While the rationalist approach fails to explain transformation of Russia’s perception of the EU, constructivists demonstrate their capacity to explain the evolution of relations between the EU and Russia and the changes of Russia’s policy towards the EU. This article studies the evolution of Russia’s perception of the European Union within the context of EU-Russia relations and their possible theoretical interpretations. In order to examine Russia’s perception of the EU, a constructivist theoretical framework is used with a special focus on imitation and social learning. The imitation process is illustrated by * ORCID ID: https://orcid.org/0000-0002-8287-7687, Associate Professor at the Department of European Studies, School of International Relations, St Petersburg State University, Russian Federation. 195 S T U D IA I A N A L IZ Y NATALIA G. ZASLAVSKAYA Russia’s implementation of democratic norms and practices; the social learning concepts are used to evaluate political ideas used by Russia to show its vision of the EU and relations with the EU.
Morphologic Features on MR Imaging Classify Multifocal Glioblastomas in Different Prognostic Groups

BACKGROUND AND PURPOSE: Multifocal glioblastomas (ie, glioblastomas with multiple foci, unconnected in postcontrast pretreatment T1-weighted images) represent a challenge in clinical practice due to their poor prognosis. We wished to obtain imaging biomarkers with prognostic value that have not been found previously. MATERIALS AND METHODS: A retrospective review of 1155 patients with glioblastomas from 10 local institutions during 2006–2017 provided 97 patients satisfying the inclusion criteria of the study and classified as having multifocal glioblastomas. Tumors were segmented and morphologic features were computed using different methodologies: 1) measured on the largest focus, 2) aggregating the different foci as a whole, and 3) recording the extreme value obtained for each focus. Kaplan-Meier, Cox proportional hazards, correlations, and Harrell concordance indices (c-indices) were used for the statistical analysis. RESULTS: Age (P < .001, hazard ratio = 2.11, c-index = 0.705), surgery (P < .001, hazard ratio = 2.04, c-index = 0.712), contrast-enhancing rim width (P < .001, hazard ratio = 2.15, c-index = 0.704), and surface regularity (P = .021, hazard ratio = 1.66, c-index = 0.639) measured on the largest focus were significant independent predictors of survival. Maximum contrast-enhancing rim width (P = .002, hazard ratio = 2.05, c-index = 0.668) and minimal surface regularity (P = .036, hazard ratio = 1.64, c-index = 0.600) were also significant. A multivariate model using age, surgery, and contrast-enhancing rim width measured on the largest foci classified multifocal glioblastomas into groups with different outcomes (P < .001, hazard ratio = 3.00, c-index = 0.853, median survival difference = 10.55 months). Moreover, quartiles with the highest and lowest individual prognostic scores based on the focus with the largest volume and surgery were identified as extreme groups in terms of survival (P < .001, hazard ratio = 18.67, c-index = 0.967). CONCLUSIONS: A prognostic model incorporating imaging findings on pretreatment postcontrast T1-weighted MRI classified patients with glioblastoma into different prognostic groups.
Quality of life of menopausal women: Kashmir experience

Introduction: Menopause is a physiological event in a woman’s life. It is caused by aging of ovaries which leads to decline in the production of ovarian gonadotropins estrogen and progesterone. The deficiency of these hormones elicits various somatic, vasomotor, sexual and psychological symptoms that impair the overall quality of life of women. Objectives: (i) To determine the mean age of menopause in Kashmiri women. (ii) To evaluate the severity of menopausal symptoms among Kashmiri women. (iii) To analyze the impact of menopausal symptoms on quality of life among Kashmiri women visiting hospital. Methods: The study was conducted in the Postgraduate Department of Obstetrics and Gynaecology, Lalla Ded Hospital, Government Medical College, Srinagar. Postmenopausal Kashmiri women between the age of 45-55 years with at least one year of amenorrhea and those who had attained natural menopause in last 5 years. Information regarding socio-demographic profile and reproductive parameters (such as parity, age of menarche, regularity of menses, age of menopause, and years since last menstruation) were recorded. For assessment of the menopausal symptoms Menopause Rating Scale (MRS) was used. MRS is an 11-item questionnaire. For the assessment of health-related quality of life (HRQOL), The Menopause Specific Quality of Life Questionnaire (MENQOL) was used. Results: This study included 200 Kashmiri women aged 45-55 years with a mean age of 50.7+5.29 years. Age at natural menopause was found to be 48.6+3.75 years. The three symptoms reported to be most prevalent included joint and muscular discomfort (84.5%), physical and mental exhaustion (65.5%) and hot flushes and sweating (46.5%). Of those who reported muscle and joint discomfort, 42.6% considered the symptoms to be moderate to very severe. The highest mean score was obtained for physical domain (3.62+0.358) followed by psychosocial (2.97+0.605), vasomotor (2.73+0.945) and sexual (2.41+0.909) domains respectively. Conclusion: The current study revealed that an increase in frequency, intensity of menopausal symptoms is related to poor physical, psychological, vasomotor, and sexual health-related QOL among women in the post reproductive period.
Chirally coupled nanomagnets

Magnetic building blocks in two dimensions Artificial magnetic structures can offer a variety of functionalities in spintronics devices. Luo et al. engineered magnetic domains in Pt/Co/AlOx trilayers that had alternating in-plane and out-of-plane magnetizations. The regions interacted laterally through the so-called Dzyaloshinskii-Moriya interaction, which determined the relative sign and orientation of the magnetization in adjacent domains. Using the coupling between the domains, the researchers were able to engineer more-complex magnetic structures such as skyrmions and frustrated magnets. Science, this issue p. 1435 Magnetic regions engineered in Pt/Co/AlOx trilayers interact laterally creating 2D magnetic patterns. Magnetically coupled nanomagnets have multiple applications in nonvolatile memories, logic gates, and sensors. The most effective couplings have been found to occur between the magnetic layers in a vertical stack. We achieved strong coupling of laterally adjacent nanomagnets using the interfacial Dzyaloshinskii-Moriya interaction. This coupling is mediated by chiral domain walls between out-of-plane and in-plane magnetic regions and dominates the behavior of nanomagnets below a critical size. We used this concept to realize lateral exchange bias, field-free current-induced switching between multistate magnetic configurations as well as synthetic antiferromagnets, skyrmions, and artificial spin ices covering a broad range of length scales and topologies. Our work provides a platform to design arrays of correlated nanomagnets and to achieve all-electric control of planar logic gates and memory devices.
Reproductive period and risk of dementia in a diverse cohort of health care members

Objective Women have >50% greater lifetime risk of dementia than men but the role of female-specific endocrine milieu is not well-understood. This study evaluates associations between indicators of estrogen exposure from women's reproductive period and dementia risk in a large diverse population. Methods We evaluated 15,754 female members (29.9% nonwhite) of Kaiser Permanente with clinical examinations and health survey data from 1964 to 1973 and were members as of January 1, 1996. In midlife (mean age 51.1 years), women reported age at menarche and menopause and hysterectomy status. Reproductive span was calculated as menopause age minus menarche age. Dementia diagnoses were abstracted from January 1, 1996 to September 30, 2017 medical records (mean age at start of dementia follow-up 76.5 years). Cox proportional hazard models evaluated associations between aspects of reproductive span and dementia risk adjusting for demographics and life course health indicators. Results Forty-two percent of women developed dementia. Compared to menarche at age 13.0 (mean menarche age), menarche at ≥16 was associated with 23% greater dementia risk (adjusted hazard ratio [HR] 1.23; 95% confidence interval [CI] 1.01–1.50) adjusting for demographics and life course health indicators. Natural menopause at age <47.4 (mean menopause age) was associated with 19% elevated dementia risk (HR 1.19; 95% CI 1.07–1.31). Reproductive spans <34.4 years (mean duration) were associated with 20% elevated dementia risk (HR 1.20; 95% CI 1.08–1.32). Hysterectomies were associated with 8% elevated dementia risk (HR 1.08; 95% CI 1.01–1.16). Conclusion In this large prospective cohort study, endocrine events signaling less estradiol exposure (i.e., later age at menarche, younger age at menopause, shorter reproductive span, and hysterectomies) were associated with elevated risk of dementia.
Phylogenetic position and morphology of Andrewia gen. nov. (Hemiptera: Miridae), a new plant bug genus from New Guinea

A new plant bug genus and species, Andrewia bochkovi gen. et sp. nov., of the Phylinae is described from the Biak Island, Papua Province of Indonesia. The described species has been characterised molecularly based on COI, 16S and 28S markers, and its phylogenetic position has been tested using model‐based (RAxML and Bayesian) phylogenetic analyses. Photographs of habitus, male and female genitalia, illustrations of male genitalia, scanning electron micrographs of morphological structures and host information are also provided. The systematic position of the new genus within Phylinae is discussed. Andrewia gen. nov. forms a separate clade sister to all other phylines except for the tribe Hallodapini.
Utility of positron emission tomography-computed tomography in patients with chronic lymphocytic leukemia following B-cell receptor pathway inhibitor therapy

The utility of positron emission tomography-computed tomography (PET-CT) in distinguishing Richter’s transformation versus chronic lymphocytic leukemia (CLL) progression after ibrutinib and/or idelalisib was assessed in a post hoc analysis of a phase II study of venetoclax. Patients underwent PET-CT at screening and were not enrolled/treated if Richter’s transformation was confirmed pathologically. Of 167 patients screened, 57 met criteria for biopsy after PET-CT. Of 35 patients who underwent biopsy, eight had Richter’s transformation, two had another malignancy, and 25 had CLL. A PET-CT maximum standardized uptake value (SUVmax) ≥10 had 71% sensitivity and 50% specificity for detecting Richter’s transformation [Odds Ratio (OR): 2.5, 95%CI: 0.4-15; P=0.318]. Response rate to venetoclax was similar for screening SUVmax <10 versus ≥10 (65% vs. 62%) (n=127 enrolled), though median progression-free survival was longer at <10 months (24.7 vs. 15.4 months; P=0.0335). Six patients developed Richter’s transformation on venetoclax, of whom two had screening biopsy demonstrating CLL (others did not have a biopsy) and five had screening SUVmax <10. We have defined the test characteristics for PET-CT to distinguish progression of CLL as compared to Richter’s transformation when biopsied in patients treated with B-cell receptor signaling pathway inhibitors. Overall diminished sensitivity and specificity as compared to prior reports of patients treated with chemotherapy/chemoimmunotherapy suggest it has diminished ability to discriminate these two diagnoses using a SUVmax ≥10 cutoff. This cutoff did not identify venetoclax-treated patients with an inferior response but may be predictive of inferior progression-free survival. (Registered at clinicaltrials.gov identifier: 02141282)
Cost and cost-effectiveness of health behavior change interventions implemented with self-help groups in Bihar, India

Introduction Health interventions implemented with self-help groups (SHGs) enhance the relevance and acceptability of the health services. The Parivartan program was implemented in eight districts of Bihar with women’s self-help groups to increase adoption of maternal and newborn health behaviors through layering health behavior change communication. This study estimates the cost and cost-effectiveness of a health behavior change program with SHGs in Bihar. Methods Cost analysis was conducted from a provider’s perspective. All costs have been presented in US dollars for the purpose of international comparisons and converted to constant values. The effectiveness estimate was based on the reported changes in select newborn care practices. A decision model approach was used to estimate the potential number of neonatal deaths averted based on adoption of key newborn care practices. Using India’s life expectancy of 65 years, cost per life year saved was calculated. A one-way sensitivity analysis was conducted using the upper and lower estimates for various variables in the model, and functionality of SHGs. Results The cost of forming an SHG group was US$254 and that of reaching a woman within the group was US$19. The unit cost for delivering health interventions through the Parivartan program was US$148 per group and US$11 per woman reached. During an 18 months period, Parivartan program reached around 17,120 SHGs and an estimated 20,544 pregnant women resulting in an estimated prevention of 23 neonatal deaths at a cost of US$3,825 per life year saved. Conclusion SHGs can be an effective platform to increase uptake of women’s health interventions and follow-up care, and also to broaden their utility beyond microfinance, particularly when they operate at a larger scale.
CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene

Objectives Circular RNAs (circRNA) expression aberration has been identified in various human diseases. In this study, we investigated whether circRNAs could act as competing endogenous RNAs to regulate the pathological process of osteoarthritis (OA). Methods CircRNA deep sequencing was performed to the expression of circRNAs between OA and control cartilage tissues. The regulatory and functional role of CircSERPINE2 upregulation was examined in OA and was validated in vitro and in vivo, downstream target of CircSERPINE2 was explored. RNA pull down, a luciferase reporter assay, biotin-coupled microRNA capture and fluorescence in situ hybridisation were used to evaluate the interaction between CircSERPINE2 and miR-1271-5 p, as well as the target mRNA, E26 transformation-specific-related gene (ERG). The role and mechanism of CircSERPINE2 in OA was also explored in rabbit models. Results The decreased expression of CircSERPINE2 in the OA cartilage tissues was directly associated with excessive apoptosis and imbalance between anabolic and catabolic factors of extracellular matrix (ECM). Mechanistically, CircSERPINE2 acted as a sponge of miR-1271-5 p and functioned in human chondrocytes (HCs) through targeting miR-1271-5 p and ERG. Intra-articular injection of adeno-associated virus-CircSERPINE2-wt alleviated OA in the rabbit model. Conclusions Our results reveal an important role for a novel circRNA-CircSERPINE2 in OA progression. CircSERPINE2 overexpression could alleviate HCs apoptosis and promote anabolism of ECM through miR-1271-ERG pathway. It provides a potentially effective therapeutic strategy for OA progression.
Characteristics of mental health recovery narratives: Systematic review and narrative synthesis

Background Narratives of recovery from mental health distress have played a central role in the establishment of the recovery paradigm within mental health policy and practice. As use of recovery narratives increases within services, it is critical to understand how they have been characterised, and what may be missing from their characterisation thus far. The aim of this review was to synthesise published typologies in order to develop a conceptual framework characterising mental health recovery narratives. Method A systematic review was conducted of published literature on the characteristics of mental health recovery narratives. Narrative synthesis involved identifying characteristics and organising them into dimensions and types; and subgroup analysis based on study quality, narrator involvement in analysis, diagnosis of psychosis and experience of trauma. The synthesis was informed by consultation with a Lived Experience Advisory Panel and an academic panel. The review protocol was pre-registered (Prospero CRD42018090188). Results 8951 titles, 366 abstracts and 121 full-text articles published January 2000-July 2018 were screened, of which 45 studies analysing 629 recovery narratives were included. A conceptual framework of mental health recovery narratives was developed, comprising nine dimensions (Genre; Positioning; Emotional Tone; Relationship with Recovery; Trajectory; Use of Turning Points; Narrative Sequence; Protagonists; and Use of Metaphors), each containing between two and six types. Subgroup analysis indicated all dimensions were present across most subgroups, with Turning Points particularly evident in trauma-related studies. Conclusions Recovery narratives are diverse and multidimensional. They may be non-linear and reject coherence. To a greater extent than illness narratives, they incorporate social, political and rights aspects. Approaches to supporting development of recovery narratives should expand rather than reduce available choices. Research into the narratives of more diverse populations is needed. The review supports trauma-informed approaches, and highlights the need to understand and support post-traumatic growth for people experiencing mental health issues.
Absence of Distinct Immunohistochemical Distribution of Annexin A5, C3b, C4d, and C5b-9 in Placentas From Patients With Antiphospholipid Antibodies, Preeclampsia, and Systemic Lupus Erythematosus

Introduction In pregnancy, the presence of preeclampsia (PEC), systemic lupus erythematosus (SLE), and/or antiphospholipid antibody syndrome (APLS) is characterized by poor obstetric outcomes, with potential adverse effects for both mother and fetus. Although the histopathologic changes observed in these entities have been well established, the pathogenic mediators associated with tissue injury are poorly understood. Methods Forty placentas were evaluated, including 10 patients with preeclampsia, 9 with SLE, 11 with APLS, and 10 disease-free controls. Each case was subjected to a panel of immunohistochemical markers including C3b, C4d, Annexin A5, and C5b-9. Staining was graded on intensity and distribution. Results C4d staining was distinctly different among disease groups and controls. Moreover, 6/10 PEC cases, 3/9 SLE cases, and 4/11 APLS cases showed at least focal staining for C4d. All controls were negative. Annexin A5 (AnxA5) staining showed intrinsic variability in all disease groups, while 10/10 controls showed diffuse, strong staining (2+ or 3+). C3b staining was heterogeneous among groups. Discussion Previously, antiphospholipid antibody (aPLA)-associated pregnancy complications have been thought to be a consequence of a unique aPLA-mediated pathogenic mechanism. However, the immunohistochemical similarity (increased complement and decreased AnxA5 staining) observed in placentas from patients with APLS, PEC, and SLE suggests that aPLA-associated pregnancy complications may reflect a more general autoimmune mechanism.
Predicting individual-level income from Facebook profiles

Information about a person’s income can be useful in several business-related contexts, such as personalized advertising or salary negotiations. However, many people consider this information private and are reluctant to share it. In this paper, we show that income is predictable from the digital footprints people leave on Facebook. Applying an established machine learning method to an income-representative sample of 2,623 U.S. Americans, we found that (i) Facebook Likes and Status Updates alone predicted a person’s income with an accuracy of up to r = 0.43, and (ii) Facebook Likes and Status Updates added incremental predictive power above and beyond a range of socio-demographic variables (ΔR2 = 6–16%, with a correlation of up to r = 0.49). Our findings highlight both opportunities for businesses and legitimate privacy concerns that such prediction models pose to individuals and society when applied without individual consent.