Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing the Influence of Propylthiouracil and Phenytoin on the Metabolomes of the Thyroid, Liver, and Plasma in Rats

The thyroid hormones (THs) regulate various physiological mechanisms in mammals, such as cellular metabolism, cell structure, and membrane transport. The therapeutic drugs propylthiouracil (PTU) and phenytoin are known to induce hypothyroidism and decrease blood thyroid hormone levels. To analyze the impact of these two drugs on systemic metabolism, we focused on metabolic changes after treatment. Therefore, in a rat model, the metabolome of thyroid and liver tissue as well as from the blood plasma, after 2-week and 4-week administration of the drugs and after a following 2-week recovery phase, was investigated using targeted LC-MS/MS and GC-MS. Both drugs were tested at a low dose and a high dose. We observed decreases in THs plasma levels, and higher doses of the drugs were associated with a high decrease in TH levels. PTU administration had a more pronounced effect on TH levels than phenytoin. Both drugs had little or no influence on the metabolomes at low doses. Only PTU exhibited apparent metabolome alterations at high doses, especially concerning lipids. In plasma, acylcarnitines and triglycerides were detected at decreased levels than in the controls after 2- and 4-week exposure to the drug, while sphingomyelins and phosphatidylcholines were observed at increased levels. Interestingly, in the thyroid tissue, triglycerides were observed at increased concentrations in the 2-week exposure group to PTU, which was not observed in the 4-week exposure group and in the 4-week exposure group followed by the 2-week recovery group, suggesting an adaptation by the thyroid tissue. In the liver, no metabolites were found to have significantly changed. After the recovery phase, the thyroid, liver, and plasma metabolomic profiles showed little or no differences from the controls. In conclusion, although there were significant changes observed in several plasma metabolites in PTU/Phenytoin exposure groups, this study found that only PTU exposure led to adaptation-dependent changes in thyroid metabolites but did not affect hepatic metabolites.
A Study of Correlation between Sociodemographic Data and Anaemia Proxies among Women and Children

- The aim of this prospective cohort study, which was carried out over a period of six months at the government district headquarters medical college hospital in Nagapattinam, is to examine the relationship between sociodemographic information and proxies for anaemia in women, children, and the elderly. The most prevalent disease, anaemia, affects up to one-third of the world's population. Children under the age of 5, infants, and young children under the age of two, as well as women who are of reproductive age, are the population groups most at risk for anaemia. In the study, 60 people with anaemia and only 53 people from 11 to over 50 years old had their Spearman correlation performed. Severe anaemia is the most prevalent type of anaemia, and in this study, women over 50 were the age group most frequently affected. The relationship between various sociodemographic parameters and laboratory characteristics is demonstrated by the spearman correlation. The frequency distribution of anaemia proxies, sociodemographic factors, and lifestyle traits are found to correlate directly with anaemia in patients.
Good Corporate Governance and Corporate Social Responsibility on Firm Value

This study aims to empirically examine the influence of independent commissioners and corporate social responsibility on firm value in state-owned and manufacturing companies listed on the Indonesia Stock Exchange. The population in this study are state-owned and manufacturing companies listed on the Indonesia Stock Exchange (IDX). The selection of this research sample was carried out by purposive sampling method. Based on the existing criteria, 30 companies became the research sample. Data were analyzed using descriptive statistical tests, classical assumption tests (normality test, heteroscedasticity test, multicollinearity test) and multiple linear regression analysis, coefficient of determination test, partial test and simultaneous test, which were processed using the SPSS program. The data analysis results show that Good Corporate Governance, proxied by independent commissioners, has a positive and significant influence on the value of BUMN and manufacturing companies listed on the Indonesia Stock Exchange. Meanwhile, Corporate Social Responsibility has a positive and insignificant effect on the value of BUMN and manufacturing companies listed on the Indonesia Stock Exchange.Keywords:Good Corporate Governance, Corporate Social Responsibility, Firm Value
Digital Commons@Georgia Southern

In recent years there has been a significant uptick in people expressing feelings of being burnt out. Many studies have looked at burnout in other students, such as college athletes, but none have looked at the true freshman first-year student. This study applied this intervention to a group of first-year college students to examine the impact of making gratitude lists on feelings of burnout. When comparing a control group that did not engage in gratitude list making, there was no statistically significant difference in feelings of burnout. However, correlation analyses revealed connections between gratitude and burnout variables that may lay a foundation for future research.
Data worth analysis within a model-free data assimilation framework for soil moisture flow

Abstract. Conventional data worth (DW) analysis for soil water problems depends on physical dynamic models. The widespread occurrence of model structural errors and the strong nonlinearity of soil water flow may lead to biased or wrong worth assessment. By introducing the nonparametric data worth analysis (NP-DWA) framework coupled with the ensemble Kalman filter (EnKF), this real-world case study attempts to assess the worth of potential soil moisture observations regarding the reconstruction of fully data-driven soil water flow models prior to data gathering. The DW of real-time soil moisture observations after Gaussian process training and Kalman update was quantified with three representative information metrics, including the trace, Shannon entropy difference and relative entropy. The sequential NP-DWA framework was examined by a number of cases in terms of the variable of interest, spatial location, observation error, and prior data content. Our results indicated that, similarly to the traditional DW analysis based on physical models, the overall increasing trend of the DW from the sequential augmentation of additional observations within the NP-DWA framework was also susceptible to interruptions by localized surges due to never-experienced atmospheric conditions (i.e., rainfall events). The difference is that this biased DW in the former is caused by model structural errors triggered by contrasting scenarios, which is difficult to be compensated for by assimilating more prior data, while this performance degradation in the NP-DWA can be effectively alleviated by enriching training scenarios or the appropriate amplification of observational noise under extreme meteorological conditions. Nevertheless, a substantial expansion of the prior data content may cause an unexpected increase in the DW of future potential observations due to the possible introduction of ensuing observation noises. Hence, high-quality and representative small data may be a better choice than unfiltered big data. Compared with the observations in the surface layer with the strongest time variability, the soil water content in the middle layer robustly exhibited remarkable superiority in the construction of model-free soil moisture models. We also demonstrated that the DW assessment performance was jointly determined by 3C, i.e., the capacity of potential observation realizations to capture actual observations, the correlation of potential observations with the variables of interest and the choice of DW indicators. Direct mapping from regular meteorological data to soil water content within the NP-DWA mitigated the adverse effects of nonlinearity-related interference, which thus facilitated the identification of the soil moisture covariance matrix, especially the cross-covariance.
Single versus Dual-Operator Approaches for Percutaneous Coronary Interventions within Chronic Total Occlusion—An Analysis of 27,788 Patients

(1) Background: Since the treatment of chronic total occlusion (CTO) with percutaneous coronary intervention (PCI) is associated with high procedural complexity, it has been suggested to use a multi-operator approach. This study was aimed at evaluating the procedural outcomes of single (SO) versus dual-operator (DO) CTO-PCI approaches. (2) Methods: This retrospective analysis included data from the Polish Registry of Invasive Cardiology Procedures (ORPKI), collected between January 2014 and December 2020. To compare the DO and SO approaches, propensity score matching was introduced with equalized baseline features. (3) Results: The DO approach was applied in 3604 (13%) out of 27,788 CTO-PCI cases. Patients undergoing DO CTO-PCI experienced puncture-site bleeding less often than the SO group (0.1% vs. 0.3%, p = 0.03). No differences were found in the technical success rate (successful revascularization with thrombolysis in myocardial infarction flow grade 2/3) of the SO (72.4%) versus the DO approach (71.2%). Moreover, the presence of either multi-vessel (MVD) or left main coronary artery disease (LMCA) (odds ratio (OR), 1.67 (95% confidence interval (CI), 1.20–2.32); p = 0.002), as well as lower annual and total operator volumes of PCI and CTO-PCI, could be noted as factors linked with the DO approach. (4) Conclusions: Due to the retrospective character, the findings of this study have to be considered only as hypothesis-generating. DO CTO-PCI was infrequent and was performed on patients who were more likely to have LMCA lesions or MVD. Operators collaboratively performing CTO-PCIs were more likely to have less experience. Puncture-site bleeding occurred less often in the dual-operator group; however, second-operator involvement had no impact on the technical success of the intervention.
Subjective Sleep Quality Versus Objective Accelerometric Measures of Sleep and Systemic Concentrations of Sleep-Related Hormones as Objective Biomarkers in Fibromyalgia Patients

Poor quality of sleep leads to an increase in severity of the symptoms associated with fibromyalgia (FM) syndrome and vice versa. The aim of this study was to determine if the poor perceived sleep quality in FM patients could be corroborated by objective physiological determinations. Perceived sleep quality was evaluated (through the Pittsburgh Sleep Quality Index) in 68 FM patients compared to an age-matched reference group of 68 women without FM. Objective sleep quality (measured using accelerometry), and systemic concentrations of sleep-related hormones (catecholamines, oxytocin, serotonin, and melatonin) were evaluated in two representative groups from the reference control group (n = 11) and FM patients (n = 11). FM patients reported poorer subjective sleep quality compared to the reference group. However, no significant differences were found in accelerometry parameters, except for a delay in getting in and out of bed. In addition, FM patients showed no significant differences in oxytocin concentration and adrenaline/noradrenaline ratio, as well as a lower serotonin/melatonin ratio. Poor perception of sleep quality in FM patients does not correspond to objective determinations. A dysregulation of the stress response could be associated with the delay in their resting circadian rhythm and difficulty falling asleep. This would be the cause that justifies the perceived lack of rest and the fatigue they feel when waking up.
Overview of the Role of Hemogram Parameters in Determining the Severity of Abdominal Pain

Objective: Acute abdomen is a dangerous condition that necessitates attentive care. The etiology of acute abdomen is quite complex and alternative diagnostic methods are very valuable as it may indicate life-threatening conditions. The purpose of this study was to examine the role of physical examination and laboratory indicators in relation to surgical and medical treatment options in the emergency department (ED). Methods: This single-center retrospective study was conducted on 735 patients aged be-tween 18 and 90 years admitted to the ED of our hospital between January 01, 2019, and January 01, 2020. Patients’ demographics (age and gender), hospitalization data, presence of rebound and involuntary guarding, differential diagnosis, treatment approach (medical or surgical treatment), and laboratory parameters were analyzed. Results: The mean age of all patients was 45.5±18.6 years and male patients were dominant (51.1%). The most common diagnoses were acute appendicitis, acute gastroenteritis, and acute cholecystitis, respectively. Patients who had surgical treatment were significantly younger than those who received medical treatment (p<0.001). Rebound tenderness and involuntary guarding were more pronounced in the patients who received medical treat-ment. Inflammatory laboratory parameters were higher in patients who received surgical treatment. The presence of rebound tenderness, decreased age, elevated leukocyte, and neutrophil levels, as well as decreased red cell distribution width showed significant associations in favor of surgical treatment. Conclusion: Results suggest that the presence of rebound tenderness, elevated neutrophil, and decreased age may be predictive for the treatment modality in patients with acute abdomen. ABSTRACT
EXPERIMENTAL INVESTIGATION ON THE SELF-PRESERVING BEHAVIOUR OF A TURBULENT PLANE JET WITH CO-FLOW

Air curtains are often used because of their ability to limit transfers between two atmospheres without the use of physical barrier. A typical air curtain is reproduced in a wind tunnel as a submerged plane jet in a uniform co-flow. This flow is explored by crossed Hot-Wire Anemometry for different Reynolds numbers and velocity ratios. The influence of these control parameters on the self-similar behaviours is discussed.
Habitat suitability analysis in a natural peat swamp forest on Sumatran elephants using remote sensing and GIS

Abstract Context It is essential to assess the suitable habitat for elephants in order to mitigate the effects of forest fragmentation on conservation. Aims This study aimed to estimate the potential suitable habitats for Sumatran elephants in the fragmented forest in the Padang Sugihan wildlife reserve area in southern Sumatra, Indonesia. Methods The habitat suitability was analyzed using some environmental factors such as slope, elevation, land cover, distance to rivers, and distance to agricultural areas. The remote sensing, geographic information system (GIS), and MaxEnt model were used to determine the potential habitat suitability for Sumatran elephants. Results This study revealed areas of suitable habitat were evenly distributed throughout the study area, with the composition being suitable (45%), highly suitable (5%), and less suitable (50%). This study revealed the most suitable habitats were found in dense forest areas (gelam or Melaleuca cajuputi forest), which were highly affected by river adjacency, whereas agricultural areas resulted in constrained suitability and fragmentation of forested areas. Conclusions As a whole, the estimation of elephant habitat using remote sensing and GIS may guide the development of conservation strategies for elephant conservation in this region. KEY MESSAGE The Sumatran elephant (Elephas maximus sumatranus) is on the Red List of the International Union for Conservation of Nature as a species that is “Critically Endangered. ” The population of elephants has steadily declined in the Sumatra region, which is characterized by peat swamp forests and a tropical rainforest climate and is vulnerable to habitat degradation.
Tumor Growth Ameliorates Cardiac Dysfunction

Heart failure and cancer are the deadliest diseases worldwide. Murine models for cardiac remodeling and heart failure demonstrate that cardiac dysfunction promotes cancer progression and metastasis spread. Yet, no information is available on whether and how tumor progression affects cardiac remodeling. Here, we examined cardiac remodeling following transverse aortic constriction (TAC) in the presence or absence of proliferating cancer cells. We show that tumor-bearing mice, of two different cancer cell lines, display reduced cardiac hypertrophy, lower fibrosis and improved cardiac contractile function following pressure overload induced by TAC surgery. Integrative analysis of qRT-PCR, flow cytometry and immunofluorescence identified tumor-dependent M1-to-M2 polarization in the cardiac macrophage population as a mediator of the beneficial tumor effect on the heart. Importantly, tumor-bearing mice lacking functional macrophages fail to improve cardiac function and display sustained fibrosis.
Examining the Influence of Exploration and Parental Education Attainment on Students’ Acceptance of Collectivist Values

Exploration can help students access a wider range of information and make connections among values within the natural and social world. This study investigated the relationship between students’ previous exploration of their surroundings and their acceptance of collectivist values in the context of China. A sample of 343 college students was analyzed based on the Bayesian Mindsponge Framework to explore this relationship. The results revealed a positive association between students’ prior exploration of surroundings and their degree of collectivist orientation. Furthermore, parental education attainment was found to negatively moderate this association, albeit with a small effect size. These findings contribute to the understanding of how information acquisition influences students’ acceptance of collectivist values and highlight the potential role of the family infosphere in shaping this relationship.
Environment and female entrepreneurship in Southeast Asia: investigation of the environmental Kuznets curve hypothesis

This paper examines the relationship between female entrepreneurship and environmental implications in ASEAN economies. While economic growth and affluence benefit society, they come at the cost of environmental degradation, particularly rising carbon dioxide levels and ecosystem concerns. Women entrepreneurs in Southeast Asia can potentially support their families and contribute to societal development by starting their own businesses. Their ventures provide fresh perspectives on societal challenges and enable active participation and contribution to creative endeavors, leading to economic and social empowerment with ripple effects on families and communities. To assess the environmental consequences of women’s entrepreneurial activities, the study applies the bias-corrected method of moments and tests the Environmental Kuznets Curve hypothesis across ten ASEAN nations from 1980 to 2021. Results show cross-sectional dependence in all variables and confirm a long-term relationship within the EKC model. The fixed-effects estimator with bias correction is deemed the most suitable model. Findings indicate that GDPpc leads to decreased emissions, while the square of GDPpc contributes to increased emissions; however, the cubic term of GDPpc leads to decreased CO2 emissions, supporting the “inverted N” curve distribution of emissions across ASEAN nations proposed by the EKC theory. Additionally, the study reveals that higher percentages of female entrepreneurs are associated with increased carbon dioxide emissions, potentially due to increased efforts to support and develop female entrepreneurs. Conversely, a reduction in the gender gap in marriage, divorce, remarriage, and domestic violence leads to a shift away from entrepreneurial activities among women, positively impacting the environment.
Effects of Statin Treatment on the Development of Tendinopathy: A Nationwide Population-Based Cohort Study

Background: Previous longitudinal cohort studies have reported the conflicting results of the relationship between statin use and the development of tendinopathy disorder. It is unclear if there is a relationship between statin use, particularly the type or cumulative doses, and the development of tendinopathy disorder. Purpose: To investigate an association between statin treatment and the development of tendinopathy. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 594,130 participants were enrolled in this study in 2002 and evaluated until 2015. There were 84,102 statin users and 168,204 nonusers (controls) selected at a ratio of 1:2 using propensity score matching analysis. The types of included tendinopathy were as follows: (1) trigger finger, (2) radial styloid tenosynovitis, (3) elbow epicondylitis, (4) rotator cuff tendinopathy, and (5) Achilles tendinitis. Cox proportional hazards models with time-varying covariates were constructed to identify the association between statin use and tendinopathy development. Results: Statin treatments regardless of statin types were associated with a significantly greater risk of all types of tendinopathy development (hazard ratio, 1.435; 95% CI, 1.411-1.460) compared with no statin treatment. A trend toward risk reduction was observed according to cumulative statin doses, which was indicated by hazard ratios of 2.337 (95% CI, 2.269-2.406), 2.210 (95% CI, 2.132-2.290), and 1.1 (95% CI, 1.098-1.146) in patients with cumulative defined daily doses of 90, 91-180, and >180, respectively. Conclusion: This nationwide population-based cohort study suggests that statin use regardless of the statin type was associated with a greater risk of tendinopathy compared with that of nonusers. The risk of tendinopathy development was diluted with the increasing cumulative defined daily dose.
A group art therapy intervention model to address mental health stigma in a rural community in South Africa

Mental health stigma is one of the main reasons why individuals do not seek mental health treatment, and it can lead to discrimination and alienation. Group art therapy is a successful and economical intervention option to address mental health stigma, specifically in rural areas like Phuthaditjhaba in South Africa. This article refers to a research study where a short-duration art therapy intervention was implemented with female students in Phuthaditjhaba, a densely populated and isolated rural area in South Africa. Using a reflective action research cycle the study found that a group art therapy intervention informs the group members of mental health stigma, its repercussions, how to prevent it, and how to heal from experienced stigma. Traditional healing objects and traditions were included in the intervention, making it an inclusive and less-threatening option for different cultures. A group art therapy intervention model is presented to serve as a possible process guide for art therapists who would like to address mental health stigma in group therapy. The participants have experienced mental health stigma in Phuthaditjhaba. Their visual stories of change capture the internal changes that took place for them as a result of the intervention. They are now more aware of what stigma is, it’s repercussions, how to prevent it and how to heal from experienced stigma. Group art therapy is a suitable therapeutic paradigm for addressing mental health stigma in rural areas of South Africa.