Miracle-dz/UniFAR-FTUs huggingface dataset:
Citation for Published Item: Use Policy Modelling and Experimental Analysis of Hormonal Crosstalk in Arabidopsis

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specic permission. The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full DRO policy for further details. An important question in plant biology is how genes influence the crosstalk between hormones to regulate growth. In this study, we model POLARIS (PLS) gene function and crosstalk between auxin, ethylene and cytokinin in Arabidopsis. Experimental evidence suggests that PLS acts on or close to the ethylene receptor ETR1, and a mathematical model describing possible PLS–ethylene pathway interactions is developed, and used to make quantitative predictions about PLS–hormone interactions. Modelling correctly predicts experimental results for the effect of the pls gene mutation on endogenous cytokinin concentration. Modelling also reveals a role for PLS in auxin biosynthesis in addition to a role in auxin transport. The model reproduces available mutants, and with new experimental data provides new insights into how PLS regulates auxin concentration, by controlling the relative contribution of auxin transport and biosynthesis and by integrating auxin, ethylene and cytokinin signalling. Modelling further reveals that a bell-shaped dose–response relationship between endogenous auxin and root length is established via PLS. This combined modelling and experimental analysis provides new insights into the integration of hormonal signals in plants. This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.
Citation for Published Item: Use Policy near and Far Space: Understanding the Neural Mechanisms of Spatial Attention. Introduction

(2013) 'Near and far space : understanding the neural mechanisms of spatial attention. ', Human brain mapping. , 34 (2). pp. 356-366. The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full DRO policy for further details. Short title: 'Neural mechanisms of near and far space' ABSTRACT Visuospatial neglect is a multicomponent syndrome and one dissociation reported is between neglect for near (peripersonal) and far (extrapersonal) space. Owing to patient heterogeneity and extensive lesions it is difficult to determine the precise neural mechanisms underlying this dissociation using clinical methodology. In this study transcranial magnetic stimulation was used to examine the involvement of three areas in the undamaged brain while participants completed a conjunction search task in near and far space. The brain areas investigated were right posterior parietal cortex (rPPC), right frontal eye field (rFEF), and right ventral occipital cortex (rVO), each of which has been implicated in visuospatial processing. The results revealed a double dissociation whereby rPPC was involved for search in near space only, whilst rVO only became necessary when the task was completed in far space. These data provide clear evidence for a dorsal and ventral dissociation between the processing of near and far space, which is compatible with the functional roles previously attributed to the two streams. For example, the involvement of the dorsal stream in near space reflects its role in vision for action, since it is within this spatial location that actions can be performed. The results also revealed that rFEF is involved in the processing of visual search in both near and far space, and may contribute to visuospatial attention and/or the control of eye-movements irrespective of spatial frame. We discuss our results with respect to their clear ramifications for clinical diagnosis and neurorehabilitation.
Citation for Published Item: Use Policy Insights into the Neural Control of Locomotion from Walking through Doorways in Parkinson's Disease

(2010) 'Insights into the neural control of locomotion from walking through doorways in Parkinson's disease. resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reected in this document. Changes may have been made to this work since it was submitted for publication. The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full DRO policy for further details. Abstract Recent evidence suggests that a network of brain areas may be involved in visually guided walking. Here we study patients with Parkinson's disease (PD) who experience 'freezing' behaviour to investigate the visual control of locomotion and the role of the basal ganglia in this system. We use a variable-width doorway to measure the scaling of motor output to visual input specifying door width. By measuring walking behaviour as participants passed through the doorway, we show that both PD and healthy control participants scaled their locomotor outputs to door width. Both groups reacted to narrower doors by walking more slowly with shorter strides. However, the changes were greater in the PD group, where walking speed dramatically decreased while approaching the doorway. Such a pattern could help explain why doorways cause freezing episodes in PD. Neither explicit perceptual judgements of door width, nor performance on motor tasks, predicted the door behaviour. On the basis of these findings, we propose that PD is associated with a visuomotor disturbance, such that responses to action-relevant visual information are exaggerated. In the PD group, dopaminergic medications improved many baseline gait variables but did not affect their sensitivity to door width, suggesting that this visuomotor effect is not mediated by the basal ganglia. This hypothesis provides a novel framework for interpreting a variety of results with PD patients.
Citation for Published Item: Use Policy Gaze-dependent Topography in Human Posterior Parietal Cortex

unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full DRO policy for further details. The brain must convert retinal coordinates into those required for directing an effector. One prominent theory holds that, through a combination of visual and motor/proprioceptive information, head-/ body-centered representations are computed within the posterior parietal cortex (PPC). An alternative theory, supported by recent visual and saccade functional magnetic resonance imaging (fMRI) topographic mapping studies, suggests that PPC neurons provide a retinal/eye-centered coordinate system, in which the coding of a visual stimulus location and/or intended saccade endpoints should remain unaffected by changes in gaze position. To distinguish between a retinal/eye-centered and a head-/body-centered coordinate system, we measured how gaze direction affected the representation of visual space in the parietal cortex using fMRI. Subjects performed memory-guided saccades from a central starting point to locations " around the clock. " Starting points varied between left, central, and right gaze relative to the head-/body midline. We found that memory-guided saccadotopic maps throughout the PPC showed spatial reorganization with very subtle changes in starting gaze position , despite constant retinal input and eye movement metrics. Such a systematic shift is inconsistent with models arguing for a retinal/ eye-centered coordinate system in the PPC, but it is consistent with head-/body-centered coordinate representations.
New Approaches with Different Types of Circulating Cathodic Antigen for the Diagnosis of Patients with Low Schistosoma mansoni Load

Background Schistosomiasis mansoni is a debilitating and sometimes fatal disease. Accurate diagnosis plays a key role in patient management and infection control. However, currently available parasitological methods are laborious and lack sensitivity. The selection of target antigen candidates has turned out to be a promising tool for the development of more sensitive diagnostic methods. In our previous investigations, the use of crude antigens led to false-positive results. Recently, focus has been given to highly purified Schistosoma mansoni antigens, especially to circulating antigens. Method Thus, our main goal was to test different types of circulating cathodic antigen glycoprotein (CCA), as “crude antigen,” the protein chain of recombinant CCA and two individual peptides. These schistosome proteins/peptides were tested in a new diagnostic method employing immunomagnetic separation based on the improvement of antigen–antibody binding. Principal Findings Use of recombinant CCA as a diagnostic antigen allowed us to develop a diagnostic assay with high sensitivity and specificity with no false-negative results. Interestingly, the “crude antigen” worked as a good marker for control of cure after praziquantel treatment. Conclusions/Significance Our new diagnostic method was superior to enzyme-linked immunosorbent assay in diagnosing low endemicity patients.
Antibodies to Combat Fungal Infections: Development Strategies and Progress

The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise to the possibility of developing vaccinations that trigger protective antibody immunity. These vaccines might work by inducing antibody opsonins that improve the function of non-specific (such as neutrophils, macrophages, and NK cells) and specific (such as lymphocyte) cell-mediated immunity and stop or aid in eradicating fungus infections. The ability of antibodies to defend against fungi has been demonstrated by using monoclonal antibody technology to reconsider the function of antibody immunity. The next step is to develop vaccines that induce protective antibody immunity and to comprehend the mechanisms through which antibodies mediate protective effects against fungus.
Studi produksi dan kualitas hijauan di lahan padang rumput UPT peternakan Universitas Andalas Padang

The present research was aimed to study the quality of forages and productivity of pasture managed by the teaching farm unit (UPT) of Andalas University by taking samples of forages from 8 paddocks. Samples of forages in fresh form were collected in 5 different sampling points of each paddock by using quadrant plate meter of 0.5x0. 5 m in size. The fresh samples were weighed and then sorted by plant species for identification of botanical composition. The samples were then remixed, dried and ground for chemical analysis. Parameter measured included forage mass production, botanical composition, carrying capacity, DM and nutrient content of CP, CF and ash.Results shown that there were 12 kinds of species grown at the pasture, i.e. 5 gramineae, 4 leguminosae and 3 kinds of browse.Nutrient content of CP, CF and crde ash ranged from 7.2 to 18.7 %, 37.1 to 47.7 % and 6.6 to 10.0 % DM, respectively.Mean production of forages mass in fresh form of about 26.19 t/year with carrying capacities of 2.07 AU/paddock. The total carrying capacity of the pasture was about16.1 AU/ha. Keywords: forage mass production, forages quality, pasture
Adverse drug reactions in the view of clinical pharmacology: a focus on the female population

Purpose: Our study aimed to investigate the association between prenatal exposure to reactive intermediate (RI)-inducing drugs and the initiation of psychotropic medications among children. Methods: We designed a cohort study using a pharmacy prescription database. Pregnant women were considered exposed when they received a prescription of RI-inducing drugs. These drugs could be either used alone (RI+/FAA–) or combined with drugs exhibiting folic acid antagonism (FAA, RI+/FAA+). The reference group included pregnant women who did not receive any RI-inducing drugs or FAA drugs. Results: We analyzed 4,116 exposed and 30,422 reference pregnancies. The hazard ratio (HR) with 95% confidence interval (CI) was 1.27 (1.15-1.41) for pregnancies exposed to RI-inducing drugs as a whole. Considering subcategories of RI-inducing drugs, prenatal exposure to both RI+/FAA+ and RI+/FAA– was associated with the children’s initiation of psychotropic medications, HRs (95%CI) being 1.35 (1.10-1.66) and 1.26 (1.13-1.41), respectively. The HRs were increased with prolonged exposure to RI-inducing drugs, especially in the first and second trimesters. In a detailed examination of the psychotropics, the incidences of receiving antimigraine preparations and psychostimulants were significantly increased for the exposed children, compared with the reference children. The incidences of receiving antipsychotics and hypnotics were also higher for the exposed children; however, the HRs did not reach significance after adjustment. Conclusions: We found a significantly increased incident use of psychotropic medications among children prenatally exposed to RI-inducing drugs, especially during the first and second trimesters. This suggests a detrimental effect during critical periods of brain development.
SENIOR PROJECT

Leadership, despite being a broad concept, is exhibited in different forms by different people who are in charge. Displaying diverse levels of leadership is a form of professionalism and education. The difference in the level of employee satisfaction can be linked to the impact of these opposed styles. This papers’ focus is on the influence of different leadership style in hotel industry in Albania. Lacking professional education and training, this concept is extensively confused with being a boss. This paper focuses on whether or not there is a strong correlation between leadership level and employee satisfaction in hotels in Albania. There are two methods used; a poll distributed to 30 young adults who are seniors in high school and the MLQ questionnaire distributed to current employees in 6 big hotels in Tirana, Albania. The results highly support the hypothesis which states that the connection between the two is very strong.
Psychodynamic mechanism and weight reduction in obesity group therapy - first observations with different attachment styles in patients therapists Psychodynamische Mechanismen und Gewichtsreduktion in der GruppentherapieAdipöser-ersteBeobachtungenzudenAuswirkungen der verschiedenen Bindungsstile

Objectives: Successful long-term results are extremely rare in non-sur- gical obesity treatment. Interactional difficulties with the attending 1 described dilemma in repeated psychotherapeutic group treatment at- Bettina Kallenbach-Dermutz 1 tempts. The type of relationship initiation and the attachment behavior probably play a central role in this connection but have not yet been systematically investigated. Andreas F.H. Pfeiffer 2 Methods: This paper focuses on the attachment styles of obese subjects and their effects on psychodynamic group therapy within the context of a weight-reduction program.
Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis

Background: The application of neoadjuvant immune checkpoint inhibitors combined with chemotherapy (NICT) in treating locally advanced oesophageal squamous cell carcinoma (ESCC) is a subject of considerable research interest. In light of this, we undertook a comprehensive meta-analysis aiming to compare the efficacy and safety of this novel approach with conventional neoadjuvant chemotherapy (NCT) in the management of ESCC. Methods: A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science to gather relevant literature on the efficacy and safety of NICT compared to conventional NCT in locally advanced ESCC published before June 2023. Effect indicators, including odds ratios (ORs) with associated 95% CIs, were employed to evaluate the safety and efficacy outcomes. The risk of bias was assessed using the Cochrane bias risk assessment tool, and subgroup analysis and sensitivity analysis were conducted to investigate the findings further. Results: A total of nine studies qualified for the meta-analysis, all of which investigated the efficacy and safety of NICT compared to conventional NCT. The pooled rates of pathologic complete response and major pathologic response in the NICT group were significantly higher compared to the NCT group, with values of 26.9% versus 8.3% (P<0.00001) and 48.1% versus 24.6% (P<0.00001), respectively. The ORs for achieving pathologic complete response and major pathologic response were 4.24 (95% CI, 2.84–6.32, I2=14%) and 3.30 (95% CI, 2.31–4.71, I2=0%), respectively, indicating a significant advantage for the NICT group. Regarding safety outcomes, the pooled incidences of treatment-related adverse events and serious adverse events in the NICT group were 64.4% and 11.5%, respectively, compared to 73.8% and 9.3% in the NCT group. However, there were no significant differences observed between the two groups in terms of treatment-related adverse events (OR=0.67, 95% CI, 0.29–1.54, P=0.35, I2=58%) or serious adverse events (OR=1.28, 95% CI, 0.69–2.36, P=0.43, I2=0%). Furthermore, no significant differences were found between the NICT and NCT groups regarding R0 resection rates, anastomotic leakage, pulmonary infection, and postoperative hoarseness. Conclusions: Neoadjuvant immune checkpoint inhibitors combined with chemotherapy demonstrate efficacy and safety in treating resectable oesophageal squamous cell carcinoma. Nevertheless, additional randomized trials are required to confirm the optimal treatment regimen.
Middle Cambrian (Wulingian) linguliformean brachiopods form the Paibi section, Huaqian Formation, Hunan Province, South China,

Twelve linguliformean brachiopod species, one new, are documented from the Middle Cambrian (undefined Series 3, Wulingian, Ptychagnostus atavus - Linguagnostus reconditus Zones) limestone deposits within the Paibi section (GSSP for the Paibian Stage and Furongian Series) of the Huaqiao Formation, northwest Hunan Province, South China. The species comprise Anabolotreta tegula Rowell and Henderson, 1978, Anabolotreta? glabra Streng and Holmer, 2006, Araktina? sp. , Dactylotreta n. sp. , Dysoristus? sp. , Linnarssonia ophirensis (Walcott, 1902), Micromitra sp. cf. M. modesta (Lochman, 1940), Neotreta sp. cf. N. tumida Sobolev, 1976, Obolidae gen. et sp. indet. , Pegmatreta clavigera Engelbretsen, 1996, Quadrisonia sp. and Treptotreta jucunda Henderson and MacKinnon, 1981.
Animal Research: Reporting In Vivo Experiments: The ARRIVE guidelines

2 Provide an accurate summary of the background, research objectives, including details of the species or strain of animal used, key methods, principal findings and conclusions of the study. INTRODUCTION Background 3 a. Include sufficient scientific background (including relevant references to previous work) to understand the motivation and context for the study, and explain the experimental approach and rationale. b. Explain how and why the animal species and model being used can address the scientific objectives and, where appropriate, the study’s relevance to human biology. Objectives 4 Clearly describe the primary and any secondary objectives of the study, or specific hypotheses being tested. METHODS Ethical statement 5 Indicate the nature of the ethical review permissions, relevant licences (e.g. Animal [Scientific Procedures] Act 1986), and national or institutional guidelines for the care and use of animals, that cover the research. Study design 6 For each experiment, give brief details of the study design including: a. The number of experimental and control groups. b. Any steps taken to minimise the effects of subjective bias when allocating animals to treatment (e.g. randomisation procedure) and when assessing results (e.g. if done, describe who was blinded and when). c. The experimental unit (e.g. a single animal, group or cage of animals). A time-line diagram or flow chart can be useful to illustrate how complex study designs were carried out. Experimental procedures 7 For each experiment and each experimental group, including controls, provide precise details of all procedures carried out. For example: a. How (e.g. drug formulation and dose, site and route of administration, anaesthesia and analgesia used [including monitoring], surgical procedure, method of euthanasia). Provide details of any specialist equipment used, including supplier(s). b. When (e.g. time of day). c. Where (e.g. home cage, laboratory, water maze). d. Why (e.g. rationale for choice of specific anaesthetic, route of administration, drug dose used). Experimental animals 8 a. Provide details of the animals used, including species, strain, sex, developmental stage (e.g. mean or median age plus age range) and weight (e.g. mean or median weight plus weight range). b. Provide further relevant information such as the source of animals, international strain nomenclature, genetic modification status (e.g. knock-out or transgenic), genotype, health/immune status, drug or test naı̈ve, previous procedures, etc. DOI: 10.1113/expphysiol.2010. 053793 C © 2010 The Authors. Journal compilation C © 2010 The Physiological Society Exp Physiol 95.8 pp 842–844 Editorial 843