Miracle-dz/UniFAR-FTUs huggingface dataset:
Exosome‐associated microRNA‐375 induces cell proliferation by regulating IGFBP4 upon hepatitis C virus infection

Hepatitis C virus (HCV) infection is one of the most common causes of liver cancer. HCV infection causes chronic disease followed by cirrhosis, which often leads to hepatocellular carcinoma (HCC). In this study, we investigated the roles of exosome‐associated miRNAs in HCV‐induced disease pathology. Small RNA sequencing was performed to identify miRNAs that are differentially regulated in exosomes isolated from patient sera at two different stages of HCV infection: cirrhosis and hepatocellular carcinoma. Among the differentially expressed miRNAs, miR‐375 was found to be significantly upregulated in exosomes isolated from patients with cirrhosis and HCC. A similar upregulation was observed in intracellular and extracellular/exosomal levels of miR‐375 in HCV‐JFH1 infected Huh7.5 cells. The depletion of miR‐375 in infected cells inhibited HCV‐induced cell migration and proliferation, suggesting a supportive role for miR‐375 in HCV pathogenesis. miR‐375, secreted through exosomes derived from HCV‐infected cells, could also be transferred to naïve Huh7.5 cells, resulting in an increase in cell proliferation and migration in the recipient cells. Furthermore, we identified Insulin growth factor binding protein 4 (IGFBP4), a gene involved in cell growth and malignancy, as a novel target of miR‐375. Our results demonstrate the critical involvement of exosome‐associated miR‐375 in HCV‐induced disease progression.
Cores and cusps in warm dark matter halos

The apparent presence of large core radii in Low Surface Brightness galaxies has been claimed as evidence in favor of warm dark matter. Here we show that WDM halos do not have cores that are large fractions of the halo size: typically, rcore/r20010−3. This suggests an astrophysical origin for the large cores observed in these galaxies, as has been argued by other authors.
Oligomers in polybutylene terephthalate for food contact—strategies on identification, quantification, and risk assessment

Abstract Oligomers are a significant group of migrating substances from food contact materials made of polyesters like polybutylene terephthalate (PBT). Twenty-three cyclic and linear oligomers with different end groups including olefin-terminated oligomers, which are associated with thermal stress of the material, were tentatively identified in PBT extracts by high-performance liquid chromatography with mass spectrometry and diode array detection. Quantification approaches based on chromophore concentration, relative response factors, and overall oligomer determination after hydrolysis to the monomer terephthalic acid were employed. An exhaustive extraction of thirteen PBT samples yielded an overall oligomer content of 1.87–6.10 mg/g material (sum of individual oligomers < 1,000 Da) with a predominant content of cyclic over linear oligomers. Migration experiments were performed according to Regulation (EU) No. 10/2011 using the official food simulants as well as cows’ milk. A total of 218 µg cyclic oligomers/L milk were detected in the third migrate relevant for risk assessment of repeated-use articles under hot-fill conditions (70 °C, 2 h). The official food simulant for milk, 50% ethanol, was found to overestimate the actual migration into milk by a factor of four. Frying conditions using sunflower oil as the food simulant (200 °C, 10 min) resulted in a migration of 7.5 mg cyclic oligomers/kg oil. The exposure to migrating oligomers is critical in some scenarios when evaluated by the threshold of toxicological concern concept; however, the toxicological evaluation poses a challenge due to the possible hydrolysis of cyclic oligomers in the human gastrointestinal tract. Our experiments display the need for a toxicological evaluation of PBT oligomers because the migration of cyclic oligomers is expected to exceed the current in silico–based thresholds under foreseeable conditions of use.
Effects of abscisic acid on growth and selenium uptake in medicinal plant Perilla frutescens

The aim of the present study was to explore the effects of abscisic acid (ABA) on growth and selenium (Se) absorption of the medicinal plant, Perilla frutescens. A pot experiment was conducted to evaluate the effects of different ABA concentrations (0, 1, 5, 10 and 20 μmol/L) on the physiological characteristics and Se absorption capacity of P. frutescens. Application of 5, 10 and 20 μmol/L ABA increased the shoot biomass of P. frutescens, and only 5 and 10 μmol/L ABA increased the root biomass. Application of 5, 10, and 20 μmol/L ABA increased the contents of photosynthetic pigments (chlorophyll a, chlorophyll b, total chlorophyll, and carotenoid), superoxide dismutase activity, peroxidase activity, and soluble protein content of P. frutescens, and decreased the malondialdehyde content in P. frutescens. Only 5 and 10 μmol/L ABA used in the present study increased the catalase activity of P. frutescens. For the Se uptake, only 5 μmol/L ABA increased the Se content, Se extraction and Se bioconcentration factor of both roots and shoots. The findings of the present study indicate that 5 and 10 μmol/L ABA promotes the growth of P. frutescens, whereas 5 μmol/L ABA enhances the Se accumulation capacity in P. frutescens.
The effect of employees’ sense of power on supervisors’ voice endorsement: A cross-level moderated mediation model

Based on expectation states theory, we examined the mechanism underlying the effect of employees’ sense of power on supervisors’ voice endorsement, and tested our hypothesized model on a sample of 307 employees from 60 work teams. We used a two-time lagged design and paired questionnaire survey. Our analysis indicated that employees’ sense of power enhanced supervisors’ voice endorsement, and supervisors’ perceived voice constructiveness mediated this relationship. Multilevel analyses showed that power distance negatively moderated the influence of sense of power on perceived voice constructiveness and negatively moderated its indirect effect on voice endorsement.
Combined high NEDD9 expression and E‐cadherin loss correlate with poor clinical outcome in gastric cancer

Neural precursor cell expressed developmentally downregulated 9 (NEDD9) is a member of the Cas family. Previous studies have revealed that NEDD9 coordinates the focal adhesion kinase and Src signaling cascades that are involved in integrin‐dependent adhesion and migration, invasion, cell apoptosis and life cycle, and survival, which may play a role in epithelial–mesenchymal transformation. The aim of this study was to analyze the expression of NEDD9 and E‐cadherin in gastric cancer (GC) and evaluate their clinical significance.
A Suzaku X-ray observation of one orbit of the supergiant fast X-ray transient IGR J16479−4514

We report on a 250 ks long X-ray observation of the supergiant fast X-ray transient (SFXT) IGR J16479-4514 performed with Suzaku in 2012 February. During this observation, about 80% of the short orbital period (P(sub orb) approximates 3.32 days) was covered as continuously as possible for the first time. The source light curve displays variability of more than two orders of magnitude, starting with a very low emission state (10(exp 13) erg / sq cm/s; 1-10 keV) lasting the first 46 ks, consistent with being due to the X-ray eclipse by the supergiant companion. The transition to the uneclipsed X-ray emission is energy dependent. Outside the eclipse, the source spends most of the time at a level of 6-7X10)(exp12) erg/sq. cm/s) punctuated by two structured faint flares with a duration of about 10 and 15 ks, respectively, reaching a peak flux of 3-4X10(exp 11) erg/sq. cm. /S, separated by about 0.2 in orbital phase. Remarkably, the first faint flare occurs at a similar orbital phase of the bright flares previously observed in the system. This indicates the presence of a phase-locked large scale structure in the supergiant wind, driving a higher accretion rate onto the compact object. The average X-ray spectrum is hard and highly absorbed, with a column density, NH, of 10*exp 23)/sq cm, clearly in excess of the interstellar absorption. There is no evidence for variability of the absorbing column density, except that during the eclipse, where a less absorbed X-ray spectrum is observed. A narrow Fe K-alpha emission line at 6.4 keV is viewed along the whole orbit, with an intensity which correlates with the continuum emission above 7 keV. The scattered component visible during the X-ray eclipse allowed us to directly probe the wind density at the orbital separation, resulting in rho(sub w)=7X10(exp 14) g/cubic cm. Assuming a spherical geometry for the supergiant wind, the derived wind density translates into a ratio M(sub w)/v(sub infinity) = 7X10(exp 17) Solar M/km which, assuming terminal velocities in a large range 500-3000 km/s, implies an accretion luminosity two orders of magnitude higher than that observed. As a consequence, a mechanism should be at work reducing the mass accretion rate. Different possibilities are discussed.
The Association Between Vitamin D Level and Chest Pain, Anxiety, and Fatigue in Patients With Coronary Artery Disease

This study sought to assess the association between vitamin D deficiency (VDD) and chest pain, anxiety, and fatigue in patients with coronary artery disease (CAD). A cross-sectional study was conducted to collect data from a sample of 90 participants with CAD. Serum 25OHD3 was measured using a radioimmunoassay procedure. Chest pain was assessed using the Numeric Pain Rating Scale, anxiety using the Anxiety Subscale, and fatigue by the General Fatigue subscale. The majority of participants (80%) had VDD. Results showed that the level of vitamin D was significantly negatively associated with chest pain (r = −.43, p = .00); anxiety (r = −.466, p = .00); and fatigue (r = −.25, p = .018). Findings suggest the role of VDD in heightened central sensitivity in cardiac-related symptoms such as chest pain, anxiety, and fatigue. Patients with CAD should be monitored for VDD so that the condition can be corrected.
Effect of sacubitril/valsartan on cognitive impairment in colchicine‐induced Alzheimer's model in rats

Alzheimer's disease (AD) is a complex neurodegenerative disease. There is epidemiological evidence that heart failure (HF) patients are at higher risk of developing AD, and the impact of sacubitril/valsartan, the first angiotensin receptor‐neprilysin inhibitor (ARNI) approved for HF, on cognitive functions is still controversial. To investigate the effect of sacubitril/valsartan on cognitive functions in colchicine‐induced AD rat model. Forty adult male Wistar rats were equally allocated into four groups (each of 10 rats): Group I: normal control, Group II: intracerebroventricular injection of colchicine (15 μg/5 μl/bilaterally), Group III: colchicine (15 μg/5 μl/bilaterally, icv) + oral sacubitril/valsartan (100 mg/kg/day) for 25 days, and Group IV: colchicine (15 μg/5 μl/bilaterally, icv) + oral valsartan (50 mg/kg/day) for 25 days. Behavioral assessment was done using Morris water maze and passive avoidance tasks. Biochemically, β‐amyloid (1–40 and 1–42) peptides, oxidative stress (malondialdehyde and superoxide dismutase) and inflammatory (tumor necrosis factor‐alpha) parameters were measured in hippocampus and prefrontal cortex. Sacubitril/valsartan exaggerated colchicine‐induced cognitive impairment in both Morris water maze and passive avoidance tasks and was associated with significant increase in β‐amyloid accumulation, oxidative stress, and inflammation versus valsartan. Sacubitril/valsartan caused deleterious effect on cognitive impairment and biochemical alterations in colchicine‐induced AD rat model. Hence, special caution should be taken following long‐term intake of ARNI on cognitive functions.
Blazar synchrotron emission of instantaneously power-law injected electrons under linear synchrotron, non-linear SSC, and combined synchrotron-SSC cooling

Context. The broadband spectral energy distributions (SED) of blazars show two distinct components which in leptonic models are associated with synchrotron and synchrotron self-Compton (SSC) emission of highly relativistic electrons. In some sources the SSC component dominates the synchrotron peak by one or more orders of magnitude implying that the electrons mainly cool by inverse Compton collisions with their self-made synchrotron photons. Therefore, the linear synchrotron loss of electrons, which is normally invoked in emission models, has to be replaced by a nonlinear loss rate depending on an energy integral of the electron distribution. This modified electron cooling changes significantly the emerging radiation spectra. Aims. It is the purpose of this work to apply this new cooling scenario to relativistic power-law distributed electrons, which are injected instantaneously into the jet. Methods. We assume a spherical, uniform, nonthermal source, where the distribution of the electrons is spatially and temporally isotropic throughout the source. We will first solve the differential equation of the volume-averaged differential number density of the electrons, and then discuss their temporal evolution. Since any non-linear cooling will turn into linear cooling after some time, we also calculated the electron number density for a combined cooling scenario consisting of both the linear and non-linear cooling. For all cases, we will also calculate analytically the emerging optically thin time-integrated synchrotron intensity spectrum, also named the fluence, and compare it to a numerical solution. Results. The first result is that the combined cooling scenario depends critically on the value of the injection parameter α0 . F or values α0 � 1 the electrons cool mainly linear, while in the opposite case the cooling begins non-linear and becomes linear for later times. Secondly, in all cased we find that for small normalized frequencies f < 1 the fluence spectra F(f ) exhibit power-laws with constant spectral indices F(f ) ∼ f −ϑ . We find for purely linear cooling ϑSYN = 1/2, and for purely non-linear cooling ϑSSC = 3/2. In the combined cooling scenario we obtain for the small injection parameter ϑ1 = 1/2, and for the large injection parameter ϑ2 = 3/2, which becomes ϑ1 = 1/2 for very small frequencies. These identical behaviors, as compared to the existing calculations for monoenergetically injected electrons, prove that the spectral behavior of the total synchrotron fluence is independent from the functional form of the energy injection spectrum.
Magnetic phase diagram of an extended J 1 -J 2 model on a modulated square lattice and its implications for the antiferromagnetic phase of K y Fe x Se 2

Motivated by the experimentally observed $\sqrt{5} \times \sqrt{5}$ iron vacancy order and a block spin antiferromagnetic phase with large magnetic moment in $\mathrm{K}_{0.8}\mathrm{Fe}_{1.6}\mathrm{Se}_2$, we study the magnetic phase diagram of an extended $J_1-J_2$ model on a 1/5-depleted square lattice with $\sqrt{5} \times \sqrt{5}$ vacancy order, using a classical Monte Carlo analysis. The magnetic phase diagram involves various antiferromagnetically ordered phases, and most of them have higher order commensuration. We find that the experimentally relevant block-spin state occupies a significant portion of the phase diagram, and we discuss the spin dynamics of this phase using a linear spin-wave analysis. Based on our spin wave calculations in different parameter regimes corresponding to the block spin antiferromagnetic phase, we show how spin-wave degeneracy along the high symmetry directions of the magnetic Brillouin zone can provide information regarding the underlying exchange couplings. We have also analyzed the magnetic phase diagram of a $J_1-J_2$ model on two different modulated square lattices relevant for $\mathrm{K}_y\mathrm{Fe}_{1.5}\mathrm{Se}_2$, which respectively exhibit 1/4-depleted $2\times2$ and $4\times2$ vacancy ordering.
How negative and positive constructs and comorbid conditions contribute to disability in chronic orofacial pain

Temporomandibular disorders (TMD) symptoms develop into chronic pain for some patients, but the reasons for this are unclear. Psychosocial factors and chronic overlapping pain conditions are believed to contribute to the development of pain‐related disability. We examined the role of jaw function, negative and positive psychological factors and chronic overlapping pain conditions (COPCs) on pain‐related disability whilst controlling for demographic variables.
Nonlinear theory of resonant slow waves in anisotropic and dispersive plasmas

The solar corona is a typical example of a plasma with strongly anisotropic transport processes. The main dissipative mechanisms in the solar corona acting on slow magnetoacoustic waves are the anisotropic thermal conductivity and viscosity [Ballai et al., Phys. Plasmas 5, 252 (1998)] developed the nonlinear theory of driven slow resonant waves in such a regime. In the present paper the nonlinear behavior of driven magnetohydrodynamic waves in the slow dissipative layer in plasmas with strongly anisotropic viscosity and thermal conductivity is expanded by considering dispersive effects due to Hall currents. The nonlinear governing equation describing the dynamics of nonlinear resonant slow waves is supplemented by a term which describes nonlinear dispersion and is of the same order of magnitude as nonlinearity and dissipation. The connection formulas are found to be similar to their nondispersive counterparts.
The distribution of CO in NGC 4945

A map of the 12 CO(1-0) emission from NGC 4945 obtained with the SEST at a resolution of 43″ (1.4 kpc; D = 6.7 Mpc) and an rms noise of ΔT A * ≃ 40 mK is presented. CO emission is found out to a radius of about 12 kpc. The molecular gas mass is M mol ≃ 7 10 9 M ○ . , i.e. 5% of the total dynamical mass. About half of the molecular gas resides in the central 1.1 kpc, the other half is located in the outer disk. The CO and radio continuum emission distributions are tightly correlated on scales down to 1.5 kpc. 12 CO(2-1) observations of the central part of NGC 4945 confirm the existence of a fast-rotating (υ rot ≃ 225 km s −1 ) CO gas ring with an inner radius of 200 pc and a radial thickness of 350 pc. Inside this ring CO gas falls radially into the nucleus at υ ≃ 80 km s −1
Oxygen and Neon Abundances of B-Type Stars in Comparison with the Sun

To revisit the long-standing problem of possible inconsistency concerning the oxygen composition in the current galactic gas and in the solar atmosphere (i.e., the former being appreciably lower by ~0.3 dex) apparently contradicting the galactic chemical evolution, we carried out oxygen abundance determinations for 64 mid- through late-B stars by using the O I 6156-8 lines while taking into account the non-LTE effect, and compared them with the solar O abundance established in the same manner. The resulting mean oxygen abundance was = 8.71 (+/- 0.06), which means that [O/H] (star-Sun differential abundance) is ~-0.1, the difference being less significant than previously thought. Moreover, since the 3D correction may further reduce the reference solar oxygen abundance (8.81) by ~0.1 dex, we conclude that the photospheric O abundances of these B stars are almost the same as that of the Sun. We also determined the non-LTE abundances of neon for the sample B stars from Ne I 6143/6163 lines to be = 8.02 (+/- 0.09), leading to the Ne-to-O ratio of ~0.2 consistent with the recent studies. This excludes a possibility of considerably high Ne/O ratio once proposed as a solution to the confronted solar model problem.
The Local Group Galaxy IC 1613 and its asymptotic giant branch variables

JHKs photometry is presented from a three-year survey of the central regions of the Local Group dwarf irregular galaxy IC1613. The morphologies of the colour-magnitude and colour-colour diagrams are discussed with particular reference to the supergiants and M- and C-type asymptotic giant branch (AGB) stars. Mean JHKs magnitudes, amplitudes and periods are given for five O-rich and nine C-rich Mira variables for which bolometric magnitudes are also estimated. A distance of 750 kpc ($(m-M)_0=24.37\pm 0.08$ mag) is derived for IC1613 by fitting a period-luminosity relation to the C-rich Miras. This is in agreement with values from the literature. The AGB stars exhibit a range of ages. A comparison with theoretical isochrones suggests that four luminous O-rich Miras are as young as $2\times 10^8$ yrs. One of these has a lithium absorption line in its spectrum, demonstrating that it is undergoing hot bottom burning (HBB). This supports the idea that HBB is the cause of the high luminosity of these AGB stars, which puts them above the fundamental period-luminosity (PL) relation. Further studies of similar stars, selected from their positions in the PL diagram, could provide insight into HBB. A much fainter, presumed O-rich, Mira is similar to those found in Galactic globular clusters. The C Miras are of intermediate age. The O-rich variables are not all recognized as O-rich, or even as AGB stars, on the basis of their J-Ks colour. It is important to appreciate this when using near-infrared surveys to classify AGB stars in more distant galaxies.
Limited evidence of patient-to-patient transmission of Staphylococcus aureus strains between children with cystic fibrosis, Queensland, Australia

Objectives Here we used whole genome sequencing (WGS) to understand strain diversity and potential for patient-to-patient transmission of Staphylococcus aureus among children with cystic fibrosis (CF) in Queensland, Australia. Methods S. aureus isolates (n = 401) collected between January 2018 and April 2019 from 184 patients with CF (n = 318 isolates) and 76 patients without CF (n = 83 isolates) were subjected to WGS and subsequent multilocus sequence typing (MLST), and a phylogeny was constructed from core genome single nucleotide polymorphism (SNP) analysis. The subsequent data was compared with available patient information. Results WGS revealed that patients with CF were essentially colonised by the same genotypes as those seen in patients without CF. Sequence types (ST) for our patients with CF were predominantly ST5 (20.1%), ST30 (7.3%), ST15 (6.3%) and ST8 (5.3%). Two Australian clones, ST93 and ST239, typically seen in skin infections and health-care settings, respectively, were notably absent from our patients with CF. Based on a SNP distance threshold of 14 SNPs, 20 cluster types involving 50/260 patients were evident; of these, 6 clusters contained only patients found to be siblings or otherwise living in the same household. Epidemiological relationships could not be determined for a remaining 14 cluster types involving 38 patients, comprising 2–7 (median 2) patients each. Multiple S. aureus genotypes were observed in 19/73 CF patients who provided more than one sample. Conclusion These results show that WGS is a useful tool for surveillance of S. aureus strains in children with CF and that the strains in our CF cohort were largely consistent with those circulating in patients without CF. Overall, this confirms previous findings and indicates that S. aureus acquisition in children with CF is similar to that of other patient groups, with limited evidence of potential patient-to-patient transmission within this patient group.