Miracle-dz/UniFAR-FTUs huggingface dataset:
Catamenial fluctuations in Lithium and Valproate serum levels: a systematic review.

: Several women affected by mood disorders experience higher affective instability during the premenstrual phase. On the assumption that fluctuations in drug levels might contribute to the worsening of mood symptoms, we provided a systematic review of available studies that had investigated changes in Lithium and Valproate concentrations in relation to menstrual phases. We selected five studies, 4 of which assessing catamenial fluctuations of Lithium levels and 1 those of Valproate. Study samples included women affected by bipolar disorder, healthy and epileptic women of fertile age. Preliminary results proved a close relationship between cyclic premenstrual exacerbation in affective symptoms and a significant decrease of Lithium levels during the luteal phase, despite a constant oral dose, in bipolar women. Lithium concentration instead was influenced neither by menstrual cycle phases or oral contraceptives use in healthy women. Valproate concentrations in epileptic women showed just a little, not significant decline of Valproate level during the mid-luteal phase. Pharmacokinetic gender differences in adsorption, volume distribution, hepatic metabolism and renal excretion of mood stabilizers have been supposed
Effect of teneligliptin 20 mg twice daily on glucagon like-peptide-1 (GLP-1) levels and its in�uence on non-glycemic components in non-diabetic obese individuals

Background and aims: Teneligliptin is an oral anti-diabetic agent, it can persevere GLP-1 by inhibiting DPP-4 enzyme. Also had rare incidence of hypoglycemia. Hence, the present study was aimed to test the effect of teneligliptin 20 mg twice daily along with low carbohydrate diet and physical exercise on change of body weight, insulin resistance in non-diabetic obese subjects. Methods: It is a prospective, randomized, placebo controlled, parallel group study carried out at outpatient department of an endocrinology hospital over the period of 48 weeks. Teneligliptin 20 mg twice daily 30 min before food (Low carbohydrate diet) with regular physical exercise and control group was kept with only LCD diet and regular physical exercise. The present Study was registered in clinical trial registry of India [CTRI/2020/02/023329]. Results: A total of 150 non diabetic obese subjects were randomized into test (n=75) and control group (n=75). At the end of the 48th weeks signi�cant improvement of GLP-1, SNAQ score, HOMA-IR, Triglycerides, and body weight. The mean difference and 95% CI of GLP-1 (pg/mL) was 76.42 (44.42, 148.41) (p 0.37); SNAQ score, -1.64 (-2.48, -0.81) (p 0.000); HOMA-IR, -0.9 (-0.59, -0.38) (p 0.000); Triglycerides (mg/dL) - 29.37 (-44.46, -14.07) (p 0.000); reduction of body weight (kg) -3.09 (-6.11, -0.07) (p 0.043). Conclusion: Findings of this study reveals that teneligliptin treated group showed signi�cant improvement of GLP-1 levels, reduced insulin resistance, body weight, triglycerides, appetite, and metabolic syndrome. Teneligliptin is well tolerated, except upper respiratory tract infections.
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Summary Background Bacterial vaginosis might increase HIV risk by eliciting genital inflammation and epithelial barrier disruption, whereas vaginal Lactobacillus crispatus is associated with immune quiescence and HIV protection. We investigated the effect of a live biotherapeutic containing L crispatus CTV-05 (LACTIN-V) on genital immunology and key vaginal bacteria. Methods This substudy included women aged 18–45 years who participated in the randomised, placebo-controlled, phase 2b trial of LACTIN-V to reduce bacterial vaginosis recurrence, conducted at four universities and hospitals in the USA. Women with negative results for sexually transmitted infection, pregnancy, and urinary tract infection were provided a 5-day course of vaginal metronidazole 0·75% gel. Those who met at least three of four clinical Amsel criteria for bacterial vaginosis and had a Nugent score of 4–10 from Gram staining were eligible. Participants in the LACTIN-V trial were randomly assigned (2:1) to receive either LACTIN-V or placebo, applied vaginally once per day for 5 days during the first week and then twice per week for 10 more weeks. Follow-up visits occurred 4, 8, 12, and 24 weeks after enrolment. Soluble immune factors and the absolute abundance of bacterial taxa were assayed by mutliplex ELISA and quantitative PCR. The primary outcomes were vaginal levels of IL-1α and soluble E-cadherin at 24 weeks (ie, 13 weeks after treatment cessation). Findings Between Feb 21, 2020 and March 18, 2021, we characterised genital immune parameters and the vaginal microbiota in a subset of
Incorporation and preservation of Mg in Globigerinoides sacculifer: implications for reconstructing the temperature and 18O/16O of seawater

Using bathymetric transects of surface sediments underlying similar sea surface temperatures but exposed to increasing dissolution, we examined the processes which affect the relationship between foraminiferal Mg/Ca and δ18O. We found that Globigerinoides saccculifer calcifies over a relatively large range of water depth and that this is apparent in their Mg content. On the seafloor, foraminiferal Mg/Ca is substantially altered by dissolution with the degree of alteration increasing with water depth. Selective dissolution of the chamber calcite, formed in surface waters, shifts the shell's bulk Mg/Ca and δ18O toward the chemistries of the secondary crust acquired in colder thermocline waters. The magnitude of this shift depends on both the range of temperatures over which the shell calcified and the degree to which it is subsequently dissolved. In spite of this shift the initial relationship between Mg/Ca and δ18O, determined by their temperature dependence, is maintained. We conclude that paired measurements of δ18O and Mg/Ca can be used for reconstructing δ18Owater, though care must be taken to determine where in the water column the reconstruction applies.
MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/β-catenin pathway

We investigated the miRNA profiles of breast cancer stem cells (CSCs) and non-CSC tumor cells by miRNA microarray and determined the effect of altered miR-1 expression on proliferation and migration of breast CSCs. The potential targets of miR-1 in the Wnt/β-catenin signaling were characterized by bioinformatics analysis and luciferase assay. We found that 14 miRNAs were up-regulated and 13 were down-regulated in the ESA+CD44+CD24−lineage− CSCs, related to ESA+CD44−CD24+lineage− non-CSC tumor cells. The miR-1 expression was associated inversely with aggressiveness of breast cancers. Furthermore, enhanced miR-1 expression decreased the percentages of SKBR3/CSCs and miR-1 inhibition increased the percentages of MCF-7/CSCs. Enhanced miR-1 expression significantly reduced the Frizzled 7 and Tankyrase-2 (TNKS2)-regulated luciferase activity in 293T cells and decreased Frizzled 7, TNKS2, c-Myc, octamer-binding transcription factor 4 (Oct4) and Nanog expression and the ratios of nuclear to cytoplasmic β-catenin as well as β-catenin-dependent luciferase activity in breast CSCs in vitro. miR-1 inhibited proliferation, migration and wound healing of breast CSCs in vitro. Enhanced miR-1 expression inhibited the growth of implanted MCF-7/CSCs while miR-1 inhibition promoted the growth of implanted MCF-7/CSCs in vivo. Our data indicate that miR-1 down-regulates breast CSC stemness, proliferation and migration by targeting the Frizzled 7 and TNKS2 to inhibit the Wnt/β-catenin signaling.
Early exhumation of high‐pressure rocks in extrusion wedges: Cycladic blueschist unit in the eastern Aegean, Greece, and Turkey

Structural, metamorphic, and geochronologic work shows that the Ampelos/Dilek nappe of the Cycladic blueschist unit in the eastern Aegean constitutes a wedge of high‐pressure rocks extruded during early stages of orogeny. The extrusion wedge formed during the incipient collision of the Anatolian microcontinent with Eurasia when subduction and deep underthrusting ceased and the Ampelos/Dilek nappe was thrust southward over the greenschist‐facies Menderes nappes along its lower tectonic contact, the Cycladic‐Menderes thrust, effectively cutting out a ∼30‐ to 40‐km‐thick section of crust. The upper contact of the Ampelos/Dilek extrusion wedge is the top‐to‐the‐NE Selçuk normal shear zone, along which the Ampelos/Dilek nappe was exhumed by ∼30–40 km. Detailed Rb‐Sr and 40Ar/39Ar dating of mylonites demonstrates that both shear zones operated between 42 and 32 Ma. There is no evidence for episodic motion during the ∼10 Myr life span of the shear zones, suggesting that both shear zones operated in a steady, nonepisodic fashion. Our data provide supporting evidence that simultaneous thrust‐type and normal sense shearing can accomplish the early exhumation of deep‐seated rocks.
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— Context: The technical debt (TD) metaphor helps to conceptualize the pending issues and trade-offs made during software development. Knowing TD causes can support in defining preventive actions and having information about effects aids in the prioritization of TD payment. Goal: To investigate the impact of the experience level on how practitioners perceive the most likely causes that lead to TD and the effects of TD that have the highest impacts on software projects. Method: We approach this topic by surveying 227 practitioners. Results: While experienced software developers focus on human factors as TD causes and external quality attributes as TD effects, low experienced developers seem to concentrate on technical issues as causes and internal quality issues and increased project effort as effects. Missing any of these types of causes could lead a team to miss the identification of important TD, or miss opportunities to preempt TD. On the other hand, missing important effects could hamper effective planning or erode the effectiveness of decisions about prioritizing TD items. Conclusion: Having software development teams composed of practitioners with a homogeneous experience level can erode the team’s ability to effectively manage TD.
Numerical dating in stratigraphy

In recent years many geochronologists have been attempting to establish a time scale for the Mesozoic and Cenozoic eras, based on the dating of glauconies. This book presents an up-to-date synthesis of available dara in order to calibrate, correct and specify the Phanerozoic time scale. Leading geochronologists and stratigraphers were invited to contribute their results and these new and often unpublished data have been used to complement and up-date existing data. Bentonites, glauconies, lavas and plutons were measured and potassium-argon, rubidium-strontrium, uranium-lead and fission tracks were used. As far as possible, all relevant problems and aspects have been covered. The book is devided into two parts. The first deals with methodology and time scale calibration, evaluating the analytical uncertainties and geochemical problems involved in the study of geochronometers and dating techniques, and also discusses the time scale itself. The second part gathers together 251 abstracts summarizing the available data on which the time scale is based, as well as a complete bibliography. The aim of this work is to propose a thoroughly revised time scale which will serve as a useful instrument to geologists for determining the actual duration of geological phenomena such as biological, sedimentological or geochemical evolution and the sequence or duration of tectoni and magmatic events.
Evaluation of the intrusion generated by a submerged contact chamber of hypolimnetic oxygenator in a reservoir

Abstract Physical characteristics of a hypolimnetic oxygenator known as a Water Environmental Preservation System (WEP), were investigated through field tests carried out in Sanbe Reservoir, Japan. Field data showed that the oxygen‐rich intrusion traveled at nearly the same height as the outflow opening of the device. The thickness of the intrusion, travel time and other important values were derived from the field data. The results showed the flow to be similar to that of an intrusion emanating from a bubble plume after the plunging point and was controlled by an inertia‐buoyancy force balance. The intrusion from the oxygenator was successfully simulated with a three‐dimensional hydrodynamic and water quality simulation model (ELCOM‐CAEYDM) including a simple integral model for the oxygenator.
Characteristic Transport Route of Air Parcels Arriving over Northern Japan in January

In ten years of 1994 to 2003, January air transports in the Hokkaido, Kanto, and Kyushu regions were analyzed calculating 7day backward air parcel trajectories with the meteorological wind analysis data set (NCEP-DOE AMIP-II Reanalysis). As a new result, an anomalous air parcel route was found out over the Hokkaido region: In January climatology as has been well-known so far, air parcels transported from the Eurasian continent sweep out the entire Japan Islands. In several years interval, however, only the Hokkaido region happens to be invaded by air parcels moving westwards from the Kamchatka Peninsula, although this route is not seen in the other Januarys.
Study of Significance of Echocardiography and Estimation of Serum Ferritin Levels in Beta-thalassemia Major Patients

: Objectives: Mean prevalence of thalassemia is nearly 3.5%. Approximately 4% of world’s population is carrier of alpha and beta thalassemia. Cardiac complications are the most common cause of death in β -Thalassemia major. In India, studies regarding screening of cardiac complications in first decade by echocardiography are minimal. This study was done to assess the significance of Echocardiography in early detection of cardiac complications in Beta-thalassemia major patients. Methods: This study was conducted from March-2021 to October-2022 on 60 Beta-Thalassemia major patients aged between 2 to 18 years coming to Al-Ameen Medical College Hospital, Vijayapura. Patients with congenital heart disease or terminal illness were excluded. After detailed history and clinical examination, investigations were done; which included complete blood count, serum ferritin estimation, Chest X-ray, Electrocardiography and Echocardiography. Patients were categorized into two age groups, 2-9 years and 10-18 years respectively and the results were compared. Results: 71.67% (n=43) patients had increased Left Ventricular Mass of which 40% (n=24) belonged to 10-18 years and 31.67% (n=19) belonged to 2-9 years age group. Among 16.67% (n=10) patients who had pulmonary hypertension, 10% (n=6) belonged to 10-18 years and 6.67% (n=4) belonged to 2-9 years age group. Correlation of Serum ferritin levels with Cardiac abnormalities was statistically insignificant. Conclusion: Cardiac complications
LOWER BOUNDS

We observe that proving lower bounds for the sum of set-multilinear Algebraic Branching Programs (smABPs) in the low-degree regime implies Valiant’s conjecture (i.e. it implies general ABP lower bounds). Using this connection, we obtain lower bounds for the sum of small-sized general ABPs. In particular, we show that the sum of poly( n ) ABPs, each of size ( : = number of vertices) n o (1) , cannot compute the family of Iterated Matrix Multiplication polynomials IMM n,d for any arbitrary function d = d ( n ) . We also give a dual version of our result for the sum of low-variate ROABPs (read-once oblivious ABPs). Both smABP and ROABP are very well-studied ‘simple’ models; our work puts them at the forefront of understanding Valiant’s conjecture.
Evaluating the potential of matrix metalloproteinase as a diagnostic biomarker in rheumatoid arthritis and periodontitis: A systematic review and meta-analysis

Background: Matrix metalloproteinases (MMPs) play a crucial role in the pathogenesis of several chronic diseases including rheumatoid arthritis (RA) and periodontitis (PD). RA patients with periodontitis (RA-PD) are associated with elevated inflammatory burden due to increased production of proinflammatory cytokines. Controlling upregulated MMPs activity in these patients may have potential therapeutic effects. Therefore, aim of this study is to address the focused question: “Do RA subjects with concurrent PD have different levels of MMPs in comparison to RA alone, PD alone and HC subjects? ” Methods: The systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search from 4 electronic databases (EMBASE, Medline, Web of Science, and Cochrane library) and manual search was performed from inception to July 2023. Quality assessment of each article was done using Newcastle-Ottawa Scale. Meta-analyses derived results were summarized as standardized mean difference (SMD) with 95% confidence intervals. Results: A total of 879 articles were extracted. Following screening and full text assessment, 9 studies were included. MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13 were consistently elevated in RA-PD subjects. MMP-8 levels were found to be higher in RA-PD subjects compared with RA alone, PD alone, and HC in 3 studies reporting GCF levels (SMD = 1.2; Z = 2.07; P = .04) and 2 studies reporting serum levels (SMD = 0.87; Z = 4.53; P < .00001). Conclusion: RA-PD group showed significantly higher MMP levels in their serum and GCF compared with HC, RA, and PD alone individuals. MMP-8 may serve as a reliable biomarker in the diagnosis and management of RA-PD subjects.
Altitude dependencies in the solar activity variations of the ionospheric electron density

In this study, 7 years (1986-1992) of measurements from the Japanese middle and upper atmosphere (MU) radar have been analyzed to investigate the solar activity variations of the ionosphere. The observations show strong altitude dependencies in the solar activity variations of the electron density. Below 300 km altitude, the electron density increases nonlinearly with F10.7, with the rate of increase being much lower when F10.7 is greater than 150. This nonlinear variation becomes weaker with increasing altitude. Above 450 km altitude, the electron density increases almost linearly with F10.7 when F10.7 lies in the range 100 to 250. For values of F10.7 less than 100, the electron density at low altitudes increases with increasing F10.7, while at higher altitudes (above about 400 km) the electron density remains almost constant. Mechanisms to explain the observed behavior have been investigated using the Sheffield University Plasmasphere Ionosphere Model. The model calculations show that while the variations with F10.7 of the solar EUV flux and neutral gas densities play important roles in the nonlinear variations of the electron density with F10.7, the correlation of the plasma loss rate with temperature being negative at low temperatures and positive at high temperatures is an important mechanism for the nonlinear variations at low altitudes. Model results also suggest that vibrationally excited N 2 strengthens the nonlinear variations of electron density with F10.7. The disappearance of the nonlinear variations at high altitudes, for values of F10.7 above 100, results from the altitude dependencies of the neutral gas variation on F10.7 and of the relative importance of plasma loss, production, and diffusion processes. At high altitudes, the plasma loss processes, which play an important role in the nonlinear variations at low altitudes, are unimportant when compared with the effects arising from plasma production and diffusion. The altitude dependencies of the electron density variations with F10.7, for values of F10.7 less than 100, are due mainly to the altitude dependencies of the neutral gas densities with F10.7.
Preliminary Estimates of Sediment Volume in the North Polar Sand Seas of Mars

Data from studies of the cross-sectional area of terrestrial transverse dunes have been combined with maps of dune morphometry derived from Viking orbiter images to generate new estimates of sediment thickness and dune sediment volume in the north polar sand seas of Mars. A relationship between dune spacing and equivalent sediment thickness (EST) was developed from field data on Namibian and North American dunes and was applied to data on dune spacing and dune cover measured on Viking orbiter images to generate maps of dune sediment thickness for Martian north polar sand seas. There are four major sand seas in the north polar region of Mars, covering an area of 6.8×105 km2. Equivalent sediment thickness ranges between 0.5 and 6.1 m with a mean of 1.8 m. The sand seas contain a total of 1158 km3 of dune sediment, which may have been derived by erosion of polar layered deposits and concentrated in its present location by winds that change direction seasonally.
Tongxinluo capsule in combination with conventional therapies for stable angina pectoris: A meta-analysis and systematic review

Background: This study aimed to assess the efficacy and safety of Tongxinluo capsule (TXLC) in combination with conventional therapies for treating stable angina pectoris (SAP) through a comprehensive meta-analysis and systematic review. Methods: We conducted a systematic search of the China National Knowledge Infrastructure, Wanfang, VIP, PubMed, Embase, and CENTRAL databases for randomized controlled trials investigating the use of TXLC as adjuvant therapy for SAP published up to June 2023. The Cochrane Handbook was used to evaluate the risk of bias. Meta-analysis was performed using Review Manager 5.4. 1, and publication bias was assessed using Begg test and Egger test in the Stata SE 12.0 software. GRADEpro was used to assess the quality of the evidence. Results: This meta-analysis included 26 randomized controlled trials with a total of 2352 patients. TXLC co-administration demonstrated significant reduction in angina attack frequency (mean difference (MD) −0.91, 95% confidence interval (CI) −0.97 to −0.84, P < . 00001) and duration (MD −1.71, 95% CI −2.24 to −1.19, P < .00001), decreased use of nitroglycerin tablets (MD −6.28, 95% CI −7.16 to −5.41, P < .00001), lowered C-reactive protein (MD −1.19, 95% CI −1.35 to −1.03, P < .00001) and low-density lipoprotein cholesterol levels (MD −0.68, 95% CI −0.86 to −0.51, P < .00001). TXLC co-administration did not increase gastrointestinal reactions (RR 1.17, 95% CI 0.38 to 3.57, P = .78). The Begg test and Egger test results indicated no publication bias. The evidence quality was rated as very low for frequency of angina attack, duration of angina attack, and nitroglycerin usage, and low for C-reactive protein, low-density lipoprotein cholesterol levels, and gastrointestinal reaction events. Conclusion: This meta-analysis supports TXLC as a beneficial adjunct treatment for SAP.