Miracle-dz/UniFAR-FTUs huggingface dataset:
Combination of ketogenic diet and probiotics inhibits breast cancer in mice by immune system modulation and reduction of Insulin growth factor-1

Breast cancer (BC) is the most prevalent malignancy in women and the first tumor type in the world. Ketogenic diets (KD), which are high in fat, low in carbohydrates, and sufficient in protein, can be used alone or as adjuvants with cancer drug medication as cancer therapy or prevention methods. Probiotics are nonpathogenic microorganisms or groups of bacteria that live in the gut and nourish the host body. In this work, we tested a new KD-probiotic combination against breast cancer implanted in mice. Several combination of probiotics (1×109 CFU/0.5ml) and KD (14.1 kcal/2g) reduced tumor size and enhanced cure rate. KD and combination therapy groups increased beta-hydroxybutyrate (β-OHB) while decrease blood glucose, and IGF-1.IFN-γ, IL-2, IL-4, and IL-10 serum levels were measured to assess immune reaction to various therapies. Combination and probiotics therapy raised IFN-γ, and IL-4 levels, however IL-10 level did decrease in all treated group with highest decrease in combination group. In the safety profile, probiotics, ketogenic diet, and their combination were safe. Overall, the combination of a ketogenic diet and probiotics has the potential to be utilized in the future development of anti-cancer nutrition to augment conventional therapies. Graphical abstract. Summary of the effect of Ketogenic diet, Probiotics and its combination on EMP-6 breast cancer cell and in vivo:
Factors Affect Tourism Stock Price in Indonesia

The study aims to examine which factors affect the tourism stock price more. The study uses weekly exchange rate and tourism stock prices; the inflation, interest rate, and the number of tourism use monthly data. Using descriptive statistics, correlation matrix, augmented Dickey Fuller's unit root test, VAR, the Granger causality test, and Impulse Response. The results show that all the variables in our observations have no causal relationship. Interest rates do not have a causal relationship with exchange rates, inflation, number of tourists, and tourism stock prices. The VAR models show interest rate has a negative impact on tourism stock price, exchange rate, and the number of tourists positively impacting tourism stock price. Inflation has no impact on tourism stock price. A decrease in interest rates will encourage investment to develop a business. A decrease in the IDR exchange rate against the USD will lower the product's price, so foreign tourists will feel that Indonesian goods are getting cheaper; thus, they will spend more and increase the tourism company's share price. Regulators can use the research results by lowering and maintaining the stability of interest rates, exchange rates, inflation, and increasing the number of tourists to Indonesia.
Which Is Better? Rate Versus Rhythm Control in Atrial Fibrillation: A Systematic Review

Atrial fibrillation (AF) is a common arrhythmia associated with significant morbidity and mortality. The optimal approach to managing AF, specifically rate control versus rhythm control, remains a topic of debate in clinical practice. This systematic review aims to compare the rate control and rhythm control strategies based on their clinical outcomes, quality of life, and adverse events associated with them. A comprehensive search was conducted using PubMed, Google Scholar, Science Direct, Research Gate, MEDLINE (Medical Literature Analysis and Retrieval System Online), Scopus, and Embase (Excerpta Medica dataBASE) databases. A total of 1657 research papers were identified through the search strategy, and after applying the eligibility criteria, 28 studies were selected for the analysis. The studies encompassed a range of methodologies, including randomized controlled trials, observational studies, and meta-analyses. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed for study selection, data extraction, and analysis. The outcomes of interest included all: cause mortality, stroke, bleeding events, cardiovascular hospitalizations, quality of life, and adverse effects of treatment. Data were synthesized and presented in tables, charts, and forest plots for meta-analysis where appropriate. The results indicate that both rate control and rhythm control strategies have their own merits and limitations, with the outcomes varying based on patient characteristics and comorbidities. While rhythm control strategies may lead to better symptom control and improved quality of life, rate control strategies may be associated with lower risks of adverse events and complications. This systematic review provides a comprehensive overview of the current evidence regarding rate and rhythm control strategies in AF management, offering insights for clinical decision-making and highlighting the need for individualized treatment approaches.
Is the permeability of crystalline rock in the shallow crust related to depth, lithology or tectonic setting?

The permeability of crystalline rocks is generally assumed to decrease with depth due to increasing overburden stress. While experiments have confirmed the dependence of permeability on stress, field measurements of crystalline permeability have not previously yielded an unambiguous and universal relation between permeability and depth in the shallow crust (<2.5 km). Large data sets from Sweden, Germany and Switzerland provide new opportunities to characterize the permeability of crystalline rocks in the shallow crust. Here we compile in situ permeability measurements (n = 973) and quantitatively test potential relationships between permeability, depth (0–2.5 km), lithology (intrusive and metamorphic) and tectonic setting (active and inactive). Higher permeabilities are more common at shallow depths (<1 km), but trend analysis does not support a consistently applicable and generalizable relationship between permeability and depth in crystalline rock in the shallow crust. Results suggest lithology has a weak control on permeability–depth relations in the near surface (<0.1 km), regardless of tectonic setting, but may be a more important control at depth. Tectonic setting appears to be a stronger control on permeability–depth relations in the near surface. Permeability values in the tectonically active Molasse basin are scattered with a very weak relationship between permeability and depth. While results indicate that there is no consistently applicable relationship between permeability and depth for crystalline rock in the shallow crust, some specific lithologies and tectonic settings display a statistically significant decrease of permeability with depth, with greater predictive power than a generalized relationship, that could be useful for hydrologic and earth system models.
ANF therapy® for pain management, feasibility, satisfaction, perceived symptom reduction and side effects: a real-world multisite observational study

[Purpose] Non-invasive and drug-free interventions for pain are being developed. One of them is ANF (which stands for “Amino Neuro Frequency”) Therapy®, which consists in the application of carbonized metal devices on a patient’s skin. We aimed to: 1) test perceived changes in pain intensity after ANF application, 2) record frequency and severity of side effects, 3) assess clinician and patient satisfaction, 4) explore effects on swelling and range of motion (ROM). [Participants and Methods] In this real-world multisite observational study, N=113 physical therapists in 45 countries, applied ANF to N=1,054 patients (Mage=45.2, 56.2% female) with pain complaints. Demographic data, pain intensity (NRS-11), effects of ANF on swelling and ROM, clinician and patient satisfaction and side effects were collected. [Results] Main pain locations were: low back (14.9%), knee (12.4%), neck (10%), and shoulder (9.6%). Pre-treatment pain intensity was high (Mean=7.6, SD=1.9). It significantly decreased post-treatment (Mean=3.1, SD=2.0), t(1053)=7.25, with a large effect size (Cohen’s d=2.2). Swelling decreased and ROM increased. Average satisfaction with ANF was 92/100. Patients often experienced mild side effects (42.3%): dry mouth, headache and fatigue. [Conclusion] Results show large effect sizes, high satisfaction, and mild and short-term side effects. This is very promising but should be interpreted with caution considering the study limitations.
EFFECT OF INTRA-ROW SPACING AND DATE OF HAULM CUTTING ON PRODUCTION OF SMALL SIZE TUBERS

cultivation which accounts for about 50 percent of the total cost of cultivation (3, 5). In southeast Asia, small seed is preferred as it reduces seed requirement by about 50 percent, and consequently declines total cost of cultivation by 25 percent, (1, 6). However, there is acute shortage of small size (10-20 g) healthy seed tubers. Keeping this in view, a field study was carried out to study the effect of intra-row spacing and days to haulm cutting on the production of small size tubers for seed purpose.
Simulating the climatic response of Hardangerjøkulen in southern Norway since the Little Ice Age

Glacier and ice cap volume changes currently amount to half of the total contribution from the cryosphere to sea-level rise. Ice caps and their outlet glaciers are dynamically different from the Greenland and Antarctic ice sheets, and respond considerably faster to climate change. We use a shallow-ice version of the Ice Sheet System Model (ISSM) to model the dynamics and evolution of the maritime-continental Hardangerjøkulen ice cap in southern Norway from the Little Ice Age (LIA) until today. We force the ice flow model with a dynamically calibrated mass balance history based on moraine evidence from the Little Ice Age maximum in 1750, as well as later outlet glacier front positions from moraines and direct measurements. Glaciological mass balance measurements force the model from the 1960s onwards, and we validate the model using a surface digital elevation model from 1995 and aerial photographs. The model successfully reproduces most of the LIA extent of the ice cap. Outlet glaciers retreat too far in the model for the early 1900s, while observed ice extent after 1960 is accurately represented. This coincides with the period where direct mass balance data is used as forcing, indicating its key role. A comparison with a digital elevation model from 1995 reveals a very good agreement of surface topography, except for a too thick eastern ice cap. We find a non-linear relationship between mass balance perturbations and ice volume response, where Hardangerjøkulen is more sensitive to negative than positive mass balance changes. We discuss these findings in light of reconstructed past changes and future predictions.
Studies on the Productivity and Nutrient Element Circulation in Kirigamine Grassland, Central Japan II

In the present study, seasonal change in standing crop was investigated in order to determine the annual net production of natural herbaceous communities in Mt. Kirigamine, Nagano Prefecture. Climate, soil conditions and vegetation patterns in this grassland were reported in a previous papers' . A number of authors2-8' have so far been concerned with the productivity of herbaceous communities, though many of these were of cultivated plants and pasture crops. Concerning the uncultivated herbaceous communities in Japan, many standing crop data9-20' (mainly in fresh weight) have been accumulated especially on Miscanthus sinensis-type community, the most important and familiar type in montane grassland of this country. To date, however, only a little has been written about the annual net production of M. sinensis-type community, in spite of its importance in the use and management of grassland. The method for determining the annual net production of herbaceous community is usually based on studying the annual change in standing crop, both above-ground and underground. In a plant community consisting of many species, however, seasonal peak standing crop of the vegetation as a whole is in most cases smaller than the sum total of peak standing crop of each constituent species4.7', since different species attain their peak standing crop at different times of a year. So,, standing crop determination of each species in a community should be made at frequent intervals, in order to obtain a reasonable estimate of the annual net production. In the present paper, seasonal changes in standing crop of the whole vegetation as well as of each species in Miscanthus sinensis-type and Arundinella hirta-type communities will be presented on the basis of the monthly investigations which were carried out in 1959 and 1960. Moreover, data on the productive structure of some herbaceous communities will be provided.
Long-term hydrological monitoring of soils in the terraced environment of Cinque Terre (north-western Italy)

Terraced landscapes represent one of the most widespread human-induced/man-made transformations of hilly-mountainous environments. Slope terracing produces peculiar morphologies along with unusual soil textures and stratigraphic features, which in turn strongly influence slope hydrology. The investigation of the hydrological features of terraced soils is of fundamental importance for understanding the hydrological dynamics occurring in these anthropogenic landscapes, especially during rainfall events. To this purpose, the availability of extensive field monitoring data series and of information on subsoil properties and structure is essential. In this study, multi-sensor hydrological data were acquired over a period longer than 2 years in the experimental site of Monterosso al Mare, in the Cinque Terre National Park (Liguria region, Italy), one of the most famous examples of terraced landscape worldwide. Monitoring data were coupled with accurate engineering-geological investigations to achieve the hydro-mechanical characterization of backfill soils and to investigate their hydrological response at both the seasonal and the single rainstorm scale. The results indicated that the coarse-grained, and anthropically remolded texture of the soils favors the rapid infiltration of rainwater, producing sharp changes in both soil volumetric water content and pore water pressure. Furthermore, the pattern of hydrological parameters showed seasonal trends outlined by alternating phases of slow drying and fast wetting. The study outcomes provide useful insights on the short and long-term evolution of hydrological factors operating in agricultural terraces. These findings represent a useful basis for a better understanding of the time-dependent processes that guide water circulation in terraced systems, which have a key role in controlling the occurrence of erosion and landslide processes.
PRESENT-DAY DEFORMATION ACROSS THE HAIYUAN FAULT (GANSU, CHINA) , MEASURED BY SAR INTERFEROMETRY

The Haiyuan fault is a major left-lateral fault located at the northeastern rim of Tibet. We use ERS InSAR data covering two adjacent tracks across its central segment (the ”Tianzhu seismic gap”) to characterize its mechanical behavior for the period 1993-1998. Interferograms are corrected for orbital and tropospheric errors, then selected for stacking depending on their signal to noise ratios, to derive average velocity maps for both independent tracks. A steep velocity gradient is observed across the fault, consistent with a left-lateral slip at a rate of 6.3 ±2 mm/yr below a locking depth of about 1.7 km. Such a small apparent locking depth may be indicative of transient superficial creep or related to a weak fault zone.
Deciphering the Trace Element Characteristics in Kilbourne Hole Peridotite Xenoliths: Melt–Rock Interaction and Metasomatism beneath the Rio Grande Rift, SW USA

Significant differences between bulk-rock lithophile trace element budgets and the sum of the contributions from the constituent minerals are common, if not ubiquitous, in peridotite xenoliths. Notwithstanding the possible contributions from fluid inclusions and grain-boundary glass and micro-phases, it is often difficult to reconcile the bulk-rock incompatible element budgets with those of the silicate phases. In the absence of modal metasomatism this discrepancy is often attributed to the ‘catch-all’yet often vague process of cryptic metasomatism.This study presents comprehensive petrological descriptions, major and trace element and Sr^Nd isotope data for variably metasomatized bulk-rock peridotites, host basalt, and constituent peridotite mineral phases from spinel lherzolite and harzburgite xenoliths from the Kilbourne Hole volcanic maar, New Mexico, USA. Similar measurements were also made on hand-picked interstitial glass from one of the most highly metasomatized samples in an attempt to unravel the sources, effects, and relative timings of multiple metasomatic events. Reaction textures around clinopyroxene grains are evident in the most metasomatized samples. These are accompanied by films of high-SiO2 interstitial glass, which is not in equilibrium with the primary silicate minerals. Trails of glassy melt inclusions terminate in these films against which the margins of the primary minerals appear partially resorbed. Furthermore, different styles of high field strength element fractionation [e.g. (Nb/Ta)N vs (Zr/Hf)N] are evident in the bulk-rocks and the clinopyroxenes that they host. In all of the Kilbourne Hole peridotites analysed, hand-picked, optically clean clinopyroxenes preserve a more unradiogenic Sr isotope signature than the corresponding bulk-rock. Hand-picked interstitial glass from KH03-16 reveals the most radiogenic Sr/Sr of any component recovered from these xenoliths (Sr/Sr1⁄4 0·708043 0·00009; [Sr]1⁄4 81ppm). Similarly, the Nd/Nd of the glass is amongst the most evolved of the peridotite components (Nd/Nd1⁄4 0·512893 0·000012; [Nd]1⁄4 10 ppm). However, the host basalt (Sr/Sr1⁄4 0·703953 0·00012; Nd/Nd1⁄4 0·512873 0·000013), similar in composition to that of the nearby, contemporaneous, Potrillo Volcanic Field basalts, contains nearly an order of magnitude more Sr and more than three times more Nd ([Sr]1⁄4 655 ppm; [Nd]1⁄4 34 ppm) than the interstitial glass. Despite the high Sr and Nd contents of the host basalt the evidence for basalt infiltration is scant, although the effects of melt^rock interaction, both in antiquity and more recently, are preserved in several xenoliths. Mixing between clinopyroxene and the host basalt cannot account for the full range of bulk-rock Sr^Nd isotope ratios; nearly half of the xenoliths require an additional component that could involve varying amounts of interstitial glass. In detail the behaviour of Sr and Nd isotopes has been decoupled,
Comparison of the Effectiveness of Radiotherapy with 3D-CRT, IMRT, VMAT and PT for Newly Diagnosed Glioblastoma: A Bayesian Network Meta-Analysis

Simple Summary This study investigated the effectiveness of different modern radiotherapy strategies in the treatment of patients with newly diagnosed glioblastoma using a comprehensive review of the literature from sources such as MEDLINE, Embase and the Cochrane Central Registry. It included randomized and nonrandomized trials on treatments such as three-dimensional conformal radiotherapy, intensity-modulated radiotherapy and proton therapy, assessing their impact on overall survival and progression-free survival. A Bayesian network meta-analysis was utilized to provide a nuanced comparison of the varied therapies. The analysis of 816 patients from six studies indicated the significant benefit of proton therapy in terms of the survival outcomes, suggesting that proton therapy might be most effective for primary glioblastoma. Abstract Background: This study aimed to assess the relative efficacy of modern radiotherapy strategies in patients with newly diagnosed glioblastoma. Method: A comprehensive literature review was conducted through MEDLINE, Embase and the Cochrane Central Registry of Controlled Trials of studies focused on newly diagnosed glioblastoma published up to and counting 15 September 2022. We included randomized controlled trials (RCTs) and comparative nonrandomized studies (NRSs) of radiotherapy for newly diagnosed glioblastoma. Eligible studies included patients treated with three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, volumetric modulated arc therapy or proton therapy reporting either overall survival, progression-free survival or both. The impact of different radiotherapy modalities on survival was evaluated by direct comparisons of indirect evidence and estimated hazard ratios in terms of a Bayesian network meta-analysis. Results: A total of six RCTs or NRSs comprising 816 glioblastoma patients with modern radiotherapy strategies were reviewed, yielding improved overall survival by proton therapy over all other regimens. The network meta-analysis also indicated a significant advantage of proton therapy compared with other radiotherapy strategies in regard to progression-free survival. Conclusion: Our findings suggested PT as a standard RT regime with possibly superior survival outcomes for selected patients with GBM.
Nurturing resilience in American Indian/Alaska Native preschool children: the role of cultural socialization, executive function, and neighborhood risk

Introduction American Indian and Alaska Native (AI/AN) children possess numerous cultural assets, yet higher exposures to neighborhood risks (e.g., lack of housing, crime) may present barriers to healthy cognitive development, including executive function (EF). Cultural socialization may promote resilience and support children’s early cognition, but this has not been adequately studied. The present study examined the effects of neighborhood risk and cultural socialization on EF for AI/AN preschool children. Method Parents/caregivers of 768 AI/AN preschoolers from the 2015 AI/AN Head Start Family and Community Experiences (FACES) Study rated neighborhood risk via two scales: “Neighborhood Problems” and “Environmental Conditions,” and cultural socialization practices via two scales: cultural activities and tribal language activities. Children’s EF was measured directly using the Pencil Tap Task and the Leiter-R attention subscale. Results Families perceived neighborhood risks as relatively low, and overall risk did not predict children’s EF. However, higher average language socialization was significantly related to higher EF, as were two specific language activities (encouraging children to learn their tribal language, making sure children heard their tribal language) and two cultural activities (playing AI/AN games, participating in tribal ceremonies), controlling for neighborhood risk. Discussion Findings suggest some aspects of cultural socialization may promote resilience among AI/AN preschoolers by supporting early EF. Mechanisms may include increased spiritual, social, and cultural connections, and practice with EF skills during cultural games. Future research should partner with AI/AN communities to investigate culturally grounded EF interventions and reevaluate measures of neighborhood risk to promote resilience and connectedness for AI/AN children.
Majoritic garnets monitor deep subduction fluid flow and mantle dynamics

The ultradeep mantle rocks of western Norway display three generations of majoritic garnet. The first two derive from incompatible element–depleted transition-zone mantle and exsolved pyroxene components during Archean upwelling, accretion to subcratonic lithosphere (M1 stage), and isobaric cooling until the Middle Proterozoic (M2). A subsequent Scandian (430–390 Ma) subduction cycle initiated diamond crystallization (M3). Here we report a third majoritic garnet crystallized at grain boundaries and in microfractures, and stable with pyroxene, phlogopite, and spinel in the M3 assemblage. The trace element signatures of M3 minerals indicate crustal metasomatism, phlogopite being the main large ion lithophile element repository. These features imply majorite crystallization from crust-derived subduction fluids at 200 km depth. Our finding fixes the deepest occurrence of free subduction fluid phases and indicates that garnet is a reliable monitor of deep mantle evolution and fluid-mediated chemical recycling.