Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural fingerprints of Alice in Wonderland Syndrome in patients with migraine with aura

Background: the Alice in Wonderland syndrome (AIWS) is a transient neurological disturbance characterized by visual and somatosensory misperceptions most frequently associated with migraine. The heterogeneity of the etiologies and techniques applied to investigate the reported cases have so far prevented to draw strong conclusions about the origin of AIWS symptoms. Some lines of evidence suggest that AIWS and migraine might share common pathophysiological mechanisms, therefore we set out to investigate the common and distinct neurophysiological alterations associated with these conditions in a population of migraineurs. Methods: we acquired resting-state fMRI data from 12 migraine patients with AIWS, 12 patients with migraine with typical aura (MA) and 24 age-matched healthy controls (HC). We then compared the interictal thalamic seed-to-voxel and ROI-to-ROI cortico-cortical resting-state functional connectivity between the 3 groups. Results: we found a common pattern of altered thalamic connectivity in MA and AIWS, compared to HC, with more profound and diffuse alterations observed in AIWS. The ROI-to-ROI functional connectivity analysis highlighted an increased connectivity between a lateral occipital region corresponding to area V3 and the posterior part of the superior temporal sulcus (STS) in AIWS, compared to both MA and HC. The posterior STS is a multisensory integration area, while area V3 is considered the starting point of the cortical spreading depression (CSD), the neural correlate of migraine aura. This interictal hyperconnectivity might increase the probability of the CSD to directly diffuse to the posterior STS or trigger a diaschisis phenomenon causing the AIWS symptoms during the ictal phase. Conclusions: taken together, these results suggest that AIWS in migraineurs might be a form of complex migraine aura, characterized by the involvement of associative and multisensory integration areas. The altered connectivity between early visual and multisensory associative areas provides a model for the pathophysiology of AIWS associated with other transient neurological conditions or with a structural etiology.
Displacement Ductility Limits for Pile Foundations in Cohesionless Soils

ABSTRACT The displacement ductility limit for seismic design of concrete piles is determined for the range of cohesionless soils expected in practice. The curvature ductility capacity associated with specified performance limit states, namely, the “serviceability” and “damage-control” limits, is determined based on the current provisions for confining steel. An analytical model is applied to assess the displacement ductility factor at the specified curvature ductility level. The investigated parameters include the soil stiffness, pile diameter, longitudinal reinforcement ratio, axial force level, and pile above-ground height. A set of design displacement ductility factors is recommended and verified to ensure the satisfactory seismic performance.
Description of Paralympic Athletes’ Talent Development Environment

Introduction: The contemporary studies seek to describe the appropriate environments for athletic talent development by changing procedure instead of talent identification, which is a tedious process that sometimes does not yield the desirable result. Accordingly, some studies have described the athletic talent development environment, but only a few studies have described Paralympic athletic talent development environment. Therefore, the aim of the present study was to describe Para-Asian and Paralympic athletic talent development environment. Materials and Methods: The current research was a descriptive-correlational study. The study participants consisted of 150 athletes (46 women and 104 men) who participated in the teenage and youth Para-Asian and Paralympic games between the years 2014-2018. The participants were selected using convenience sampling method. In this study, Talent Development Environment Questionnaire for Sport was used. This questionnaire comprises seven subscales: “long-term development focus”, “quality preparation”, “communication”, “understanding the athlete”, “support network”, “challenging and supportive environment”, and “long-term development fundamentals”. The obtained data were analyzed using one-sample t test. Results: The means of the four subscales of “long-term development focus” (P = 0.001), “communication” (P = 0.001), “challenging and supportive environment” (P = 0.001), and “long-term development fundamentals” (P = 0.001), were higher than average. The means of the two subscales of “support network” (P = 0.450) and “understanding the athlete” (P = 0.360) were at a moderate level. The mean of “quality preparation” (P = 0.035) was less than average. Conclusion: In talent development environment for athletes with disability, more attention should be paid to providing the athletes with continuous and always-available support of coaching staff as well as services and facilities. Additionally, the coaches should pay more attention to the athlete’s physical and mental health; so that the athlete feels his/her health is important to the coach.
Effects of 17a-Thioestradiol, 2 Estradiol Analogs, and 2 Androgens on 7,12-Dimethylbenz[a]anthracene-induced Rat Mammary Tumors1

A thiol analog of estradici, 17a-thioestradiol, was tested for antitumor activity in the 7,12-dimenthylbenz(a)anthracene-induced mammary tumor-rat experimental chemotherapy sys tem. Its effects were compared with those produced by 17aestradiol, 17/3-estradiol, testosterone propionate (TP), and 2amethyldihydrotestosterone propionate (2a-MDTP). Of the estradiols, the largest pro]X)rtion of complete remissions (CR) of all tumors in each rat was produced by 17/8-estradiol (67%) followed by 17a-thioestradiol (50%) and 17a estradici (37%). Among the androgens, 2a-MDTP yielded 70% and TP yielded 44% CR. The median duration of tumor-free status after treat ment was 12, 12, 18, 33, and 8.5 weeks, respectively, for 17/3estradiol, 17a-thioestradiol, 17<*-estradiol, 2a-MDTP, and TP.
The dark and bright side of M&As-Acquiring managers perception of M&A outcomes

The purpose of this thesis is to examine how the outcome of mergers and acquisitions are perceived from different managerial positions in the acquiring firm and how managerial expectations can affect the perception of the outcome. Empirical data were gathered through an explorative multiple case study of five acquisitions at three companies by interviewing eight managers at different positions as well as reviewing secondary data. The data was analyzed and cross-case compared in order to detect possible differences between managers at different positions. The findings shows that financial and non-financial aspects are deemed important for how the outcome is perceived by different managers. The findings further indicate that financial aspects are more prominent for managers occupying a position with financial responsibility. The non-financial aspects are on the other hand perceived as important regardless of managerial position. Lastly, the empirical findings indicate that expectations held by individual managers are more dependent on the organizational motive of the acquisition rather than the position held by the manager and that not all expectations have to be fulfilled in order for the acquisition to be perceived as successful. Keyword: Mergers and acquisitions, M&A outcome, value creation, expectations, managerial position
TEMPERATURE EFFECT ON DEVELOPMENTAL, RATE LONGEVITY AND PARASITISM OF Diaeretiella rapae (M'INTOSH) (HYMENOPTERA- APHELINIDAE)

Temperaturedependent, biological aspects longevity and parasitism of the parasitoid Diaeretiella rapae (M'Intosh) was measured at three constant temperatures (15, 25 and 30 o C) using Brevicoryne brassicae (L.) . The threshold (t0) and thermal units (DD's) of different stages of D. rapae at different temperatures, 15, 25 and 30 o C. , were studied. The rate of development of all stages increased as the temperature increase from 15 to 30 o C. The mean of thermal units recorded 117.9, 88.84 and 222.45 DDs for egg-mummy period, mummyadult period and adult longevity respectively. Also, the threshold development estimated as 2.4, 1.6 and 3.4 o C for eggmummy period, mummyadult period and adult longevity respectively.
Adsorption of Methylene Blue and Congo Red Dye from Water onto Cassava Leaf Powder

Article history: Received 11 November 2019 Received in revised form 16 April 2020 Accepted 17 April 2020 Available online 18 April 2020 The suitability of Cassava leaf (CL) as low-cost adsorbent for dyes adsorption was evaluated in this study. Methylene blue (MB) and Congo red (CR) dye was chosen as adsorbate in this work as these two types of dyes are widely used in the industries. The impact of various parameters such as adsorbent dosage, pH, temperature and contact time for dye adsorption on CL were investigated. 99.9% removal of MB dye was achieved at pH of 11.0, temperature of 45 ̊C, 0.5 g of CL under 60 minutes of contact time. Meanwhile, 99.7% removal of CR dye was obtained under similar contact time but at pH of 2.0, room temperature and smaller dosage of CL at 0.2 g. Based on the isotherms study, MB dye adsorption was best fitted in both Langmuir and Freundlich isotherms while Temkin isotherm was best fitted for CR dye adsorption on CL.
The Structural Behavior of Hybrid Structural Insulated Panels under Pure Bending Load

This paper presents the structural behavior of newly-developed hybrid structural insulated panels (SIPs) formed by incorporating lignocellulosic composites—jute fiber composite (JFC) and medium-density fiber (MDF)—as intermediate layers between aluminum skin and an expanded polystyrene (EPS) core. The investigation was conducted as an experimental work. A four-point bending load was performed to create pure bending conditions, and the samples were prepared in accordance with ASTM C 393-00 standards. Testing was performed using a 100 kN servo-hydraulic machine with a loading rate of 5 mm/min. The results show that the incorporation of intermediate JFC or MDF layers enhanced the flexural behavior of the SIPs. The ultimate loads of hybrid SIPs with JFCs or MDF were, respectively, approximately 62.59% and 168.58% higher than the ultimate load achieved by SIPs without intermediate layers. Hybrid SIPs exhibited a much larger area under the load-deflection curve than those of conventional SIPs; this points to the toughness of the material and its ability to sustain larger compression strain prior to reaching their ultimate loads, which prevents them from prematurely failing under buckling or indentation.
Indonesian Curriculum 2013: Instructional Management, Obstacles Faced by Teachers in Implementation and the Way Forward

This research aims to determine: (1) the processes of instructional management based on Curriculum 2013; (2) the constraints faced; and (3) the efforts of its solution in Elementary School in Malang City, Indonesia. This research used a qualitative approach. The research instrument is the researcher himself. Data collected by means interview, observation, and documentation. Informants in this research are supervisors, principals, and teachers. The findings of the research indicate: (1) the process of instructional management applied is from lesson activities plan, the implementation of learning activities, and learning evaluation; (2) the constraints faced by the teachers lesson plans are still not referring to the Curriculum 2013; application of learning the scientific approach by teachers less than optimal; teachers are less than optimal in applying the learning model; and teachers are not optimal assess student learning outcomes that cover three domains of learning that is the attitude, knowledge, and skills; and (3) an alternative solution of the problems faced is the need to organize assistance activities to teachers on the implementation of Curriculum 2013, which discusses the lesson plan, teaching models, scientific approach, and assessment of student learning outcomes.
ProfilesDrastic Changes in Their Gene Expression the Alveolar Space of Mice Is Associated with Trafficking of Mononuclear Phagocytes into The Inflammatory versus Constitutive

Mononuclear phagocytes enter the lungs both constitutively to maintain alveolar macrophage and dendritic cell homeostasis, as well as during lung inﬂammation, where the role of these cells is less well deﬁned. We used a transgenic mouse strain (CX 3 CR1 (cid:1) / GFP ) that harbors a GFP label in circulating monocytes to identify and sort these cells from the vascular and alveolar compartments under both constitutive and acute lung inﬂammatory conditions. Using nylon arrays combined with real-time RT-PCR for gene expression proﬁling, we found that ﬂow-sorted, highly puriﬁed mononuclear phagocytes recruited to acutely inﬂamed mouse lungs showed strongly up-regulated mRNA levels of the neutrophil chemoattractants KC, MIP-2, and IP-10, which contrasted with alveolar mononuclear phagocytes that immigrated in steady state. Similar observations were made for the lysosomal cathepsins B, L, and K being strongly up-regulated in mononuclear phagocytes upon recruitment to inﬂamed lungs but not during constitutive alveolar immigration. Inﬂammatory elicited mononuclear phagocytes also demonstrated signiﬁcantly increased mRNA levels of the cytokine TNF- (cid:2) and the PRR-associated molecules CD14, TLR4, and syndecan-4. Together, inﬂammatory elicited mononuclear phagocytes exhibit strongly increased neutrophil chemoattractants, lysosomal proteases, and LPS signaling mRNA transcripts,
The Phospholipase C in Living Cells: Activation, Inhibition, Ca 2 (cid:1) Requirement, and Regulation of M Current

We have further tested the hypothesis that receptor-mediated modulation of KCNQ channels involves depletion of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) by phosphoinositide-speciﬁc phospholipase C (PLC). We used four parallel assays to characterize the agonist-induced PLC response of cells (tsA or CHO cells) expressing M 1 muscarinic receptors: translocation of two ﬂuorescent probes for membrane lipids, release of calcium from intracellular stores, and chemical measurement of acidic lipids. Occupation of M 1 receptors activates PLC and consumes cellular PIP 2 in less than a minute and also partially depletes mono- and unphosphorylated phosphoinositides. KCNQ current is simultaneously suppressed. Two inhibitors of PLC, U73122 and edelfosine (ET-18-OCH 3 ), can block the muscarinic actions completely, including suppression of KCNQ current. However, U73122 also had many side effects that were attributable to alkylation of various proteins. These were mimicked or occluded by prior reaction with the alkylating agent N-ethylmaleimide and included block of pertussis toxin–sensitive G proteins and effects that resembled a weak activation of PLC or an inhibition of lipid kinases. By our functional criteria, the putative PLC activator m -3M3FBS did stimulate PLC, but with a delay and an irregular time course. It also suppressed KCNQ current. The M 1 receptor–mediated activation of PLC and suppression of KCNQ current were stopped by lowering intracellular calcium well below resting levels and were slowed by not allowing intracellular calcium to rise in response to PLC activation. Thus calcium release induced by PLC activation feeds back immediately on PLC, accelerating it during muscarinic stimulation in strong positive feedback. These experiments clarify important properties of receptor-coupled PLC responses and their inhibition in the context of the living cell. In each test, the suppression of KCNQ current closely paralleled the expected fall of PIP 2 . The results are described by a kinetic model.
The impact of supraglacial debris on proglacial runoff and water chemistry

Debris is known to influence the ablation, topography and hydrological systems of glaciers. This paper determines for the first time how these influences impact on bulk water routing and the proglacial runoff signal, using analyses of supraglacial and proglacial water chemistry and proglacial discharge at Miage Glacier, Italian Alps. Debris does influence the supraglacial water chemistry, but the inefficient subglacial system beneath the debris-covered zone also plays a role in increasing the ion contribution to the proglacial stream. Daily hydrographs had a lower amplitude and later discharge peak compared to clean glaciers and fewer diurnal hydrographs were found compared to similar analysis for Haut Glacier d’Arolla. We attribute these observations to the attenuating effect of the debris on ablation, smaller input streams on the debris-covered area, a less efficient subglacial system, and possible leakage into a raised sediment bed beneath the glacier. Strongly diurnal hydrographs are constrained to periods with warmer than average conditions. ‘Average’ weather conditions result in a hydrograph with reverse asymmetry. Conductivity and discharge commonly show anti-clockwise hysteresis, suggesting the more dilute, rapidly-routed melt component from the mid-glacier peaks before the discharge peak, with components from higher up-glacier and the debris-covered areas arriving later at the proglacial stream. The results of this study could lead to a greater understanding of the hydrological structure of other debris-covered glaciers, with findings highlighting the need to include the influence of the debris cover within future models of debris-covered glacier runoff.
Career Choice in Academic Medicine Systematic Review the auspices of the International Campaign to Revitalise Academic

systematically the what factors influence the decision to not choose a in academic medicine. the the bibliographies of retrieved articles. SELECTION We attempted to identify studies that residents, or staff No restrictions were placed on the study methodologies identified and all articles presenting empirical were retrieved. For cohort, case-control, and cross- sectional studies, minimum inclusion criteria were the presence of defined groups, and the ability to extract relevant data. For surveys that involved case series, minimum inclusion criteria were a description of the population, and the availability of extractable data. Minimum in- clusion criteria for qualitative studies were descriptions of the sampling strategy and methods. RESULTS: The identified abstracts; 25 articles were included in this review. Completion of an with a graduate degree or fellowship is associated with a in medicine. Of the articles identified in this review, this finding is supported by the highest quality of evidence. Similarly, the completion of research and publication of this in medical school and residency are associated with a career in academic medicine. The desire to teach, conduct research, and the intellectual stimulation and challenge provided in academia may also persuade people to choose this career path. The influence of a role model or a mentor was reported by physicians to impact their decision making. Trainees’ interest in academic medicine wanes as they progress through their residency. CONCLUSIONS: In order to revitalize academic medicine, we must engage and their throughout their training. Research opportunities for medical students, and fellowships or graduate training can meet this challenge and influence career choice. Initiatives to stimulate and maintain interest in academic medicine should be evaluated in prospective studies across multiple sites.
Calmodulin inhibition of human RyR 2 channels requires phosphorylation of RyR 2S 2808 or RyR 2S 2814

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Experimental Investigation of Membrane Materials used in Multilayer Surfacing Systems for Orthotropic Steel Deck Bridges

In the Netherlands asphaltic surfacings on orthotropic steel deck bridges (OSDB) mostly consist of two structural layers. The upper layer consists of what is known as very open porous asphalt (ZOAB) for noise reduction. For the lower layer Guss Asphalt (GA) is used. Earlier investigations have shown that the bonding characteristics of membrane layers to the surrounding materials have a very strong influence on the overall response of the steel bridge decks. Rijkswaterstaat, an agency of the Dutch Ministry of Infrastructure and the Environment, has commissioned Delft University of Technology to investigate and rank the performance of various commercially available membranes. In order to obtain insight into the response of membranes and their interaction with the surrounding materials on orthotropic steel decks, a project of evaluation of the performance of modern surfacing systems on OSDBs has been undertaken. Currently, there are various kinds of membranes provided by various companies. Thereby it was necessary to examine the bonding strength of these membrane products and to develop a ranking methodology. The research project focused on membrane performance and the effects hereof on the bridge deck as a whole. The methodology used was a multi-phase approach, which consisted of three main phases. In Phase 1, a Membrane Adhesion Test (MAT) device was developed at Delft University of Technology for the characterization of the adhesive bonding strength of membranes with the surrounding materials on OSDBs on the basis of a fundamentally sound, mechanistic methodology. Several membrane products were tested monotonically in this phase. In Phase 2, the MAT device was utilised for investigation of the fatigue response of the various membrane products on various substrates and under two different temperature conditions and three different cyclic load levels. A ranking methodology consisting of a combination of experimental (via MAT) and computational investigations was also developed and utilized for the ranking of the various membrane products. In Phase 3 of the project, four typical Dutch multilayer surfacing systems, constructed with five selected membrane products from Phase 1 and 2, were studied by means of five-point bending (5PB) beam tests and FE simulations. The findings of the 5PB beam tests were used for calibration and validation of the finite element predictions and for further ranking of the performance of the various membranes in Dutch OSDBs. On the basis of the project results, the top two ranking membranes were selected for subsequent testing by means of the LINTRACK facility available at Delft University of Technology.
Long-Term Comparison of Drug-Eluting Stents and Coronary Artery Bypass Grafting for Multivessel Coronary Revascularization

Methods We evaluated 3,042 patients with multivessel disease who received DES (n 1,547) or underwent CABG (n 1,495) between January 2003 and December 2005, and for whom complete follow-up data were available for a median 5.6 years (interquartile range: 4.6 to 6.3 years). We compared adverse outcomes (death; a composite outcome of death, myocardial infarction, or stroke; and repeat revascularization).