Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunotherapy and Targeted Therapy for Hepatocellular Carcinoma: A Literature Review and Treatment Perspectives

Advanced hepatocellular carcinoma is a prevalent and potentially aggressive disease. For more than a decade, treatment with sorafenib has been the only approved therapeutic approach. Moreover, no agent has been proven to prolong survival following the progression of disease after sorafenib treatment. However, in recent years, this scenario has changed substantially with several trials being conducted to examine the effects of immunotherapy and novel targeting agents. Several immune checkpoint inhibitors have shown promising results in early-stage clinical trials. Moreover, phase III trials with large cohorts have demonstrated remarkable improvement in survival with the use of new targeted therapies in second-line treatment. Treatment regimens involving the combination of two immune checkpoint inhibitors as well as immune checkpoint inhibitors and anti-angiogenic targeted therapies have shown potential to act synergistically in clinical trials. Recently, the combination of atezolizumab and bevacizumab evaluated in a phase III clinical trial has demonstrated survival superiority in the first-line treatment; it is the new considered standard of care. In this manuscript, we aimed to review the latest advances in the systemic treatment of advanced hepatocellular carcinoma focusing on immunotherapy and targeted therapies.
Persistent Pulmonary Hypertension in Corrected Valvular Heart Disease: Hemodynamic Insights and Long‐Term Survival

Background The determinants and consequences of pulmonary hypertension after successfully corrected valvular heart disease remain poorly understood. We aim to clarify the hemodynamic bases and risk factors for mortality in patients with this condition. Methods and Results We analyzed long‐term follow‐up data of 222 patients with pulmonary hypertension and valvular heart disease successfully corrected at least 1 year before enrollment who had undergone comprehensive hemodynamic and imaging characterization as per the SIOVAC (Sildenafil for Improving Outcomes After Valvular Correction) clinical trial. Median (interquartile range) mean pulmonary pressure was 37 mm Hg (32–44 mm Hg) and pulmonary artery wedge pressure was 23 mm Hg (18–26 mm Hg). Most patients were classified either as having combined precapillary and postcapillary or isolated postcapillary pulmonary hypertension. After a median follow‐up of 4.5 years, 91 deaths accounted for 4.21 higher‐than‐expected mortality in the age‐matched population. Risk factors for mortality were male sex, older age, diabetes mellitus, World Health Organization functional class III and higher pulmonary vascular resistance—either measured by catheterization or approximated from ultrasound data. Higher pulmonary vascular resistance was related to diabetes mellitus and smaller residual aortic and mitral valve areas. In turn, the latter correlated with prosthetic nominal size. Six‐month changes in the composite clinical score and in the 6‐minute walk test distance were related to survival. Conclusions Persistent valvular heart disease–pulmonary hypertension is an ominous disease that is almost universally associated with elevated pulmonary artery wedge pressure. Pulmonary vascular resistance is a major determinant of mortality in this condition and is related to diabetes mellitus and the residual effective area of the corrected valve. These findings have important implications for individualizing valve correction procedures. Registration URL: https://www.clinicaltrials. gov; Unique identifier: NCT00862043.
Relationship between echogenicity of deep cervical muscles and pain laterality in subjects suffering from cervicogenic headache

ABSTRACT Objective This study investigated the deep upper cervical muscles echogenicity in cervicogenic headache (CGH) patients. Methods The echogenicity of longus capitis (LCAP), rectus capitis posterior major (RCPM), and obliquus capitis superior (OCS) muscles was measured by ultrasonography and analyzed by Image J software in 17 CGH patients matched with 17 healthy subjects. Results The echogenicity of all muscles in the CGH group was higher than that in healthy subjects. The echogenicity of the LCAP muscle on the right side was significantly different between the CGH and healthy subjects (p< 0.05), but there was no difference in the echogenicity of RCPM and OCS muscles between the groups (p> 0.05). Additionally, the echogenicity differences did not match with the pain side in CGH patients (p> 0.05). Conclusion Only the deep anterior muscle (LCAP) echogenicity affected by CGH and fatty infiltration occurred in this muscle. Hence, anterior muscle dysfunction is important in CGH diagnosis and treatment.
A Study on the Cultural Influence on Business Negotiations: Evidence from Bangladesh

Although many individuals speak of Bangladesh as a booming trading partner, in reality, negotiating for business in Bangladesh is systematic work. In the age of globalization and an increasingly globally integrated economy, businesspeople across the world negotiate with counterparts of different cultural backgrounds more often than ever before. However, little research has been conducted to identify the influence of culture on business negotiation in Bangladesh. This study examines the relationship between culture and negotiation style in Bangladesh. The data were collected from Bangladeshi business executives who have enormous experience in business dealings. The results suggest that it is important to consider the culture within a country when examining positive business outcomes.
Polyphase deformation in the Mbé - Sassa-Bersi area: Implications on the tectono-magmatic history of the area and the tectonic evolution of the Tcholliré-Banyo and Central Cameroon Shear Zones (Central North Cameroon)

Field petrographic and structural data of the Mbe-Sassa-Bersi area exposed two main group of rock (metamorphics and plutonics) which were affected by polyphase deformation. The structural evolution is marked by four deformation phases called D1, D2, D3 and D4. The geometrical arrangement of D1 structures (flat-lying foliation, horizontal lineation, recumbent folds and overlapping) allow to linked this deformation phase to tectonic nappe verging toward SSE. The second deformation stage (D2) corresponds to simple shear dominated transpression and characterized by the evolution of the Tchollire-Banyo shear zone (TBSZ) that showing sinistral movement. The third deformation phase (D3), is marked by strain partitioning induced by transpression and links to the evolution of the Central Cameroon shear zone (CCSZ) that displays dextral motion. D1, D2 and D3 are associated to migmatization, development and emplacement of granitic magmatism. During D2 and D3, the magmatic rocks are emplaced under the control of the two main crustal shear zones (TBSZ and CCSZ). D4 deformation is responsible for the development of faults, fracture and joints and corresponds to brittle tectonic. The main NW-SE direction of faults and fractures suggest that D4 stage shows traces of the Benue trough. On the whole, Nappe tectonic, followed by transpressive tectonic are the main tectonic type developed during the Pan-African Orogeny in Central North Cameroon.
THE UNIVERSITY OF KANSAS PALEONTOLOGICAL CONTRIBUTIONS August 1994 Number 5 PHYLOGENY AND SYSTEMATICS OF THE COLEOIDEA

—The Coleoidea are a monophyletic group of cephalopods characterized by the endocochleate condition of their shell. A phylogeny presented here demonstrates that the Coleoidea comprises three natural groups, ranked as superorders: Belemnoidea Hyatt, Decabrachia Boettger, and Octobrachia Fiorini. The Belemnoidea (belemnites and aulacocerids) contains rostrum-bearing coleoids possessing a closing membrane and multilayered conotheca. The Decabrachia (teuthids and sepiids) is characterized by the possession of ten arms in which the fourth pair is modified as tentacles. The Octobrachia (octopods and vampyromorphs) contains cephalopods in which the ten-armed condition has been modified so that the second arm-pair has been lost or modified. A fourth group, the Phragmoteuthidida, is imperfectly known and may represent a stem group to the Decabrachia and Octobrachia. The systematics of the Coleoidea is revised, and an outline classification of the Coleoidea presented. The systematic status of coleoids from the Devonian Hunriichschiefer (Germany) and Permian Phosphoria Formation (Utah, USA) and the stratigraphical range of the Belemnitida are discussed. Detailed reports of the taxonomic status of the following genera are presented: Acanthoteuthis, Belemnites, Belemnosepia, Belopeltis, Conoteut his, Geoteuthis, Kerunia, Loligosepia, Orcagnia, Ostracoteuthis, Paraplesioteuthis, Plagioteuthis, Platylithophycus, Produvalia, Spirulirostrina, and Trachyteuthis. Lectotypes are designated for the following species: Acanthoteu this speciosa, Archaeosepia naefi, Belopeltis sinuatus, Conoteuthis dupinianus, Ostracoteuthis superba, and Trachyteu this ensiforrnis. Finally, three new taxa are erected in the taxonomic appendix: Actinosepiidae, Bairstowius, and Hungarosepia.
A Comparative Study of Teacher Education in Iran and the UK

This paper briefly compares teacher education in the UK system with that of Iran’s. It identifies the main differences, basically of policy and practice, in that teacher education has always been centralized in Iran, whereas it had once been more or less de‑centralized in the UK. However, teacher education is now being centralized in the UK, despite all the disagreements and dissatisfaction amongst the educators and teacher trainers. It seems that this new shift is unjustified so may result in non-professionalisation and politically inappropriate intervention as is indicated by Gilroy et al (l991-1995). The article will deal mainly with Iranian teacher education. It will conclude with an intensive of comparison that will clarify the essential different issues regarding teacher education in the two systems which is followed by some experiential suggestions and conclusions.
Thermoelectric transport in disordered metals without quasiparticles: The Sachdev-Ye-Kitaev models and holography

We compute the thermodynamic properties of the Sachdev-Ye-Kitaev (SYK) models of fermions with a conserved fermion number Q. We extend a previously proposed Schwarzian effective action to include a phase field, and this describes the low-temperature energy and Q fluctuations. We obtain higher-dimensional generalizations of the SYK models which display disordered metallic states without quasiparticle excitations, and we deduce their thermoelectric transport coefficients. We also examine the corresponding properties of Einstein-Maxwell-axion theories on black brane geometries which interpolate from either AdS4 or AdS5 to an AdS2×R2 or AdS2×R3 near-horizon geometry. These provide holographic descriptions of nonquasiparticle metallic states without momentum conservation. We find a precise match between low-temperature transport and thermodynamics of the SYK and holographic models. In both models, the Seebeck transport coefficient is exactly equal to the Q derivative of the entropy. For the SYK models, quantum chaos, as characterized by the butterfly velocity and the Lyapunov rate, universally determines the thermal diffusivity, but not the charge diffusivity.
the role of dependence as a moderating variable in the model of financial predation - a general appraisal

This multidisciplinary paper discusses the role of dependence in the consolidated model of financial predation (CMFP), a model that in part resulted from research on the concept of marketing predation, which was originally identified early in the twentieth century with the creation of the Sherman Act in the United States. Applied to the financial sector, the notion of predation refers to so-called “white-collar bandits” (financial advisors) who have a talent for luring their clients-turned preys. It is argued that dependence in an interpersonal selling relation between a client and a financial advisor acts as a moderator between the constructs of perceived predation and trust. As such, the client’s dependence on his financial advisor can have various forms, which in all events lead to vulnerability and which this advisor is prompt to capitalize upon. Identifying dependencies on the part of consumers could help in devising better control systems to limit financially-driven predatory behaviors.
Creating and Performing Contemporary Music as a Way of Learning

The article analyses the results of a case study on a workshop for contemporary music which represents an excellent example of arts partnership in Slovenia. The aim of the workshop was to stimulate creative use of contemporary musical language in connection with the development of the lifelong cultural awareness and expression competence. The results of the interviews with 17 participants of the workshop pointed out the complex occurrence of various indicators, which, at the level of personal, social and intellectual competences, determined the nature of musical expression through contemporary music and indirectly influenced the development of the lifelong cultural awareness and expression competence. Through the creative process, participants expressed motivation and sensitivity for contemporary music and developed their musical abilities as well as their sense of community and self-identity. The identified challenges included students’ lack of musical experience with contemporary music, the low priority given to contemporary music in schools as well as teachers’ lack of professional knowledge in this field.
Feasibility of Introducing Four Crops Based Cropping Patterns in Kushtia Area of Bangladesh

The trial was conducted at Multi Location Testing (MLT) site under On-Farm Research Division, BARI, Kushtia during the last week of February, 2015 to second week of February, 2017 at farmers’ field condition to find out the productivity and profitability of three alternate cropping patterns, i.e. ACP1=Mustard (var: BARI Sarisha-15) Mungbean (var: BARI Mung-6) T. Aus rice (var: BRRI dhan48) T. Aman rice (var: Binadhan-7), ACP2=Lentil (var: BARI Masur-6) Mungbean (var: BARI Mung-6) T. Aus rice (var: BRRI dhan48) T. Aman rice (var:Binadhan-7), ACP3=Wheat (var: BARI Gom-28) Mungbean (var: BARI Mung-6) T. Aus rice (var: BRRI dhan48) T. Aman rice (var:Binadhan-7) against the existing cropping pattern, i.e. ECP= Lentil (var: BARI Mashur-6) – Sesame (BARI Teel-3) T. Aman (var: Binadhan-7). Findings revealed that the required mean crop durations ranged 340-356 days for one cycle in a year in four crops based cropping patterns against 293 days in existing cropping pattern. Total seed/grain yields in terms of REY of ACP1, ACP2, and ACP3 were 14.85, 16.06 and 14.92 t ha -1 year, respectively which were 44%, 56% and 45%, respectively higher than that of existing pattern (10.30 t ha year). Mean production efficiency (32.53-40.43 kg haday), land use efficiency (93.15-97.53%) and mean gross margin ( Tk. 109393 Tk. 127834 ha) of all alternate cropping patterns were higher than that of existing cropping pattern (PE: 23.63 kg haday, LUE: 80.28% and gross margin Tk. 94929 ha). As a result, all alternate cropping patterns were agronomically feasible and economically profitable. Among the alternate cropping patterns, ACP2=Lentil (var: BARI Masur-6) Mungbean (var: BARI Mung-6) T. Aus rice (var: BRRI dhan48) T. Aman rice (var: Binadhan-7) performed the best. Therefore, farmers in Kushtia area of Bangladesh might follow the alternate cropping patterns in high and medium high land for higher crop productivity and profitability over existing cropping pattern.
Comparisons of magnetic anomalies of lithospheric origin measured by satellite and airborne magnetometers over western Canada

Crustal magnetic anomaly data from the Orbiting Geophysical Observatories 2, 4, and 6 (Pogo) satellites are compared with upward-continued aeromagnetic data between 50–85°N latitude and 220–260°E longitude. Agreement is good, both in anomaly location and in amplitude, giving confidence that it is possible to proceed with the derivation and interpretation of satellite anomaly maps in all parts of the globe. The data contain a magnetic high over the Alpha ridge suggesting continental composition and a magnetic low over the southern Canada basin and northern Canadian Arctic Islands (Sverdrup basin). The low in the Sverdrup basin corresponds to a region of high heat flow, suggesting a shallow Curie isotherm. A ridge of high field, with two distinct peaks in amplitude, is found over the northern portion of the platform deposits and a relative high is located in the central portion of the Churchill Province. No features are present to indicate a magnetic boundary between Slave and Bear Provinces, but a trend ch.
Compositional variation of apatite from rift-related alkaline igneous rocks of the Gardar Province, South Greenland

Abstract Textural and compositional variations of apatite from rift-related gabbros, syenogabbros, syenites, quartz-syenites, and nepheline syenites of the Mid-Proterozoic Gardar Province (South Greenland) are presented and compared to apatite compositions from other rock suites. The observed zoning textures of apatite are interpreted to represent (1) primary growth zonation (concentric and oscillatory) that formed during magmatic differentiation and (2) secondary irregular overgrowths, patchy zonation, and resorption textures, assigned to metasomatic overprinting due to interaction with fluids/melts and intra-crystalline diffusion. Compositional variation in the apatites is mainly due to coupled substitutions of Ca and P by variable amounts of Si, Na, and REE, which show increasing concentrations during magmatic differentiation. Furthermore, F concentrations in apatites increase from gabbroic through syenogabbroic to syenitic rocks, whereas Cl concentrations show the opposite trend. Compared to apatite compositions from gabbroic, dioritic, and granitic rocks in general, apatites from alkaline rock suites are characterized by exceptionally high contents of REE and Si and in some alkaline rocks they attain Sr contents comparable to those reported from carbonatites. Typical low Mn and S contents are probably a result of low oxygen fugacity during crystallization at relatively high temperatures.
Effect of INM on Soil Carbon Pools, Soil Quality and Sustainability in Rice-Brown Sarson Cropping System of Kashmir Valley

India is second largest rice producer accounting for 20% of global rice production. The crop plays a significant role in livelihood of the people of Jammu and Kashmir State. Although area under rice is very small (0.27 m ha), it plays an important role in the state economy (DRR Hyderabad). The total annual rice production of the state is more than 0.59 million metric tonnes, but continuous rice planting has a negative impact on soil properties, such as reduced soil nitrogen supply and organic carbon content (Doberman and Witt, 2000). Furthermore, because of long-term submergence and mineral fertilizer application, these soils experience degradation of soil quality, such as breakdown of stable aggregation and deterioration of soil organic matter (SOM), International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 7 (2017) pp. 785-809 Journal homepage: http://www.ijcmas. com
Effects of Ionic Strength on Arsenate Adsorption at Aluminum Hydroxide–Water Interfaces

Adsorption processes at mineral–water interfaces control the fate and transport of arsenic in soils and aquatic systems. Mechanistic and thermodynamic models to describe this phenomenon only consider inner-sphere complexes but recent observation of the simultaneous adsorption of inner- and outer-sphere arsenate on single crystal surfaces complicates this picture. In this study, we investigate the ionic strength-dependence of the macroscopic adsorption behavior and molecular-scale surface speciation of arsenate bound to gibbsite and bayerite. Arsenate adsorption decreases with increasing ionic strength on both minerals, with a larger effect at pH 4 than pH 7. The observed pH-dependence corresponds with a substantial decrease in surface charge at pH 7, as indicated by ζ-potential measurements. Extended X-ray absorption fine structure (EXAFS) spectroscopy finds that the number of second shell Al neighbors around arsenate is lower than that required for arsenate to occur solely as an inner-sphere surface complex. Together, these observations demonstrate that arsenate displays macroscopic and molecular-scale behavior consistent with the co-occurrence of inner- and outer-sphere surface complexes. This demonstrated that outer-sphere species can be responsible for strong adsorption of ions and suggests that environments experiencing an increase in salt content may induce arsenic release to water, especially under weakly acidic conditions.
Serum Transferrin Receptor Assay in the Diagnosis of Iron Deficiency

Serum Transferrin Receptor Assay in the Diagnosis of Iron Deficiency Transferrin receptor (TfR) is present on the surface of all cells, with the highest concentration found on erythroid precursors. Soluble TfR (sTfR) is detectable in the plasma, and its concentration increases in iron deficiency. Other causes of increased sTfR include increased erythropoiesis, such as occurs in hemolytic anemia, megaloblastic anemia and myelodysplastic syndrome. Causes of decreased sTfR include iron overload and decreased erythropoiesis, such as occurs in aplastic anemia and bone marrow ablation.
Changing Religious Beliefs among College Students.

This study asks how college attendance affects changes in students' religious beliefs, exploring factors in the college environment that account for such changes. Data for the study was derived from the 1994 Freshman Survey and 1998 College Student Survey conducted annually by the Higher Education Research Institute for the Cooperative Institutional Research Program. The sample for the study included over 4,000 students attending 76 four-year institutions; the primary dependent variable was a self-rating on changes in religious beliefs and convictions. Sections of the study cover the introduction, objectives, methodology, results, limitations, and discussion and conclusion. Some study results were contrary to what had been anticipated, e.g. while students tended to experience changes in religious beliefs, the direction of change was toward a strengthening of convictions. The study also supported past findings that students who experienced a weakening of religiosity tended to be liberal males with negative emotional health experiences; females having positive emotional health were more likely to experience a strengthening of beliefs. One unexpected finding was that religious affiliation does not necessarily make a direct difference in students' religious convictions. The study suggests increased student-faculty interactions and support for religious student organizations and activities as ways to strengthen students' religious beliefs. (Contains 25 references.) (CH) Reproductions supplied by EDRS are the best that can be made from the original document. Changing Religious Beliefs Among College Students Jenny J. Lee Graduate School of Education and Information Studies UCLA U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization originating it. Minor changes have been made to improve reproduction quality. Irv% R. Points of view or opinions stated in this document do not necessarily represent official OERI position or policy. /1.1) PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC)