Miracle-dz/UniFAR-FTUs huggingface dataset:
IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway

The Insulin-like Growth Factor I (IGF-1) signalling pathway is essential for cell growth and facilitates tumourogenic processes. We recently reported that IGF-1 induces a transcriptional programme for mitochondrial biogenesis, while also inducing expression of the mitophagy receptor BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), suggesting that IGF-1 has a key mitochondria-protective role in cancer cells. Here, we investigated this further and delineated the signaling pathway for BNIP3 induction. We established that IGF-1 induced BNIP3 expression through a known AKT serine/threonine kinase 1 (AKT)-mediated inhibitory phosphorylation on Glycogen Synthase Kinase-3β (GSK-3β), leading to activation of Nuclear Factor Erythroid 2-related Factor 2 (NFE2L2/Nrf2) and acting through the downstream transcriptional regulators Nuclear Respiratory Factor-1 (NRF1) and Hypoxia-inducible Factor 1 subunit α (HIF-1α). Suppression of IGF-1 signaling, Nrf2 or BNIP3 caused the accumulation of elongated mitochondria and altered the mitochondrial dynamics. IGF-1R null Mouse Embryonic Fibroblasts (MEFs) were impaired in the BNIP3 expression and in the capacity to mount a cell survival response in response to serum deprivation or mitochondrial stress. IGF-1 signalling enhanced the cellular capacity to induce autophagosomal turnover in response to activation of either general autophagy or mitophagy. Overall, we conclude that IGF-1 mediated a mitochondria-protective signal that was coordinated through the cytoprotective transcription factor Nrf2. This pathway coupled mitochondrial biogenesis with BNIP3 induction, and increased the cellular capacity for autophagosome turnover, whilst enhancing survival under conditions of metabolic or mitochondrial stress.
Characterization in Dual Activation by Oxaliplatin, a Platinum-Based Chemotherapeutic Agent of Hyperpolarization-Activated Cation and Electroporation-Induced Currents

Oxaliplatin (OXAL) is regarded as a platinum-based anti-neoplastic agent. However, its perturbations on membrane ionic currents in neurons and neuroendocrine or endocrine cells are largely unclear, though peripheral neuropathy has been noted during its long-term administration. In this study, we investigated how the presence of OXAL and other related compounds can interact with two types of inward currents; namely, hyperpolarization-activated cation current (Ih) and membrane electroporation-induced current (IMEP). OXAL increased the amplitude or activation rate constant of Ih in a concentration-dependent manner with effective EC50 or KD values of 3.2 or 6.4 μM, respectively, in pituitary GH3 cells. The stimulation by this agent of Ih could be attenuated by subsequent addition of ivabradine, protopine, or dexmedetomidine. Cell exposure to OXAL (3 μM) resulted in an approximately 11 mV rightward shift in Ih activation along the voltage axis with minimal changes in the gating charge of the curve. The exposure to OXAL also effected an elevation in area of the voltage-dependent hysteresis elicited by long-lasting triangular ramp. Additionally, its application resulted in an increase in the amplitude of IMEP elicited by large hyperpolarization in GH3 cells with an EC50 value of 1.3 μM. However, in the continued presence of OXAL, further addition of ivabradine, protopine, or dexmedetomidine always resulted in failure to attenuate the OXAL-induced increase of IMEP amplitude effectively. Averaged current-voltage relation of membrane electroporation-induced current (IMEP) was altered in the presence of OXAL. In pituitary R1220 cells, OXAL-stimulated Ih remained effective. In Rolf B1.T olfactory sensory neurons, this agent was also observed to increase IMEP in a concentration-dependent manner. In light of the findings from this study, OXAL-mediated increases of Ih and IMEP may coincide and then synergistically act to increase the amplitude of inward currents, raising the membrane excitability of electrically excitable cells, if similar in vivo findings occur.
Contribution of mTOR and PTEN to Radioresistance in Sporadic and NF2-Associated Vestibular Schwannomas: A Microarray and Pathway Analysis

The use of radiation treatment has increased for both sporadic and neurofibromatosis type 2 (NF2)-associated vestibular schwannoma (VS). However, there are a subset of radioresistant tumors and systemic treatments that are seldom used in these patients. We investigated molecular alterations after radiation in three NF2-associated and five sporadically operated recurrent VS after primary irradiation. We compared these findings with 49 non-irradiated (36 sporadic and 13 NF2-associated) VS through gene-expression profiling and pathway analysis. Furthermore, we stained the key molecules of the distinct pathway by immunohistochemistry. A total of 195 differentially expressed genes in sporadic and NF2-related comparisons showed significant differences based on the criteria of p value < 0.05 and a two-fold change. These genes were involved in pathways that are known to be altered upon irradiation (e.g., mammalian target of rapamycin (mTOR), phosphatase and tensin homolog (PTEN) and vascular endothelial growth factor (VEGF) signaling). We observed a combined downregulation of PTEN signaling and an upregulation of mTOR signaling in progressive NF2-associated VS after irradiation. Immunostainings with mTOR and PTEN antibodies confirmed the respective molecular alterations. Taken together, mTOR inhibition might be a promising therapeutic strategy in NF2-associated VS progress after irradiation.
Beta Neurofeedback Training Improves Attentional Control in the Elderly

One of the well-documented behavioral changes that occur with advancing age is a decline in executive functioning, for example, attentional control. Age-related executive deficits are said to be associated with a deterioration of the frontal lobes. Neurofeedback is a training method which aims at acquiring self-control over certain brain activity patterns. It is considered as an effective approach to help improve attentional and self-management capabilities. However, studies evaluating the efficacy of neurofeedback training to boost executive functioning in an elderly population are still relatively rare and controversial. The aim of our study was to contribute to the assessment of the efficacy of neurofeedback as a method for enhancing executive functioning in the elderly. We provided a group of seniors with beta up-training (12–22 Hz), consisting of 20 sessions (30 minutes each), on the Cz site and tested its possible beneficiary influence on attentional control assessed by means of the Stroop and Simon tasks. The analysis of the subjects’ mean reaction times during consecutive tasks in the test and the retest, after implementation of neurofeedback training, showed a significant improvement. In contrast, the difference in reaction times between the test and the retest in the control group who had not been submitted to neurofeedback training was not significant.
Treatment of functional dyspepsia with acupuncture on Zusanli and Neiguan with lansoprazole

Objective To study the effect of acupuncture on Zusanli and Neiguan with lansoprazole on functional dyspepsia.Methods 112 cases with functional dyspepsia were randomly divided into treatment and control groups.The control group was treated with lansoprazole and mosapride.The treatment group was treated with acupuncture on Zusanli and Neiguan with lansoprazole and mosapride.Results The total efficiency rate of the control group and treatment group were 72.40% and 88.9%. The difference was statistically significant.Conclusion It is effective to treat functional dyspepsia with acupuncture on Zusanli and Neiguan with lansoprazole and mosapride.
Evaluation of Health Literacy Level among 18-65 Year-Old Adults in Shahriar, Iran

espanolEn la etapa de la vejez es importante el estudio de las emociones y de como estas afectan en la adaptacion y calidad de vida de las personas mayores. Algunos autores ponen de manifiesto la importancia de la inteligencia emocional y la calidad de vida. La alexitimia supone una dificultad en la identificacion y descripcion de las emociones y un estilo cognitivo orientado hacia lo externo. El objetivo es estudiar la relacion entre inteligencia emocional, calidad de vida y alexitimia en un grupo de ancianos. Los participantes fueron 25 ancianos de un centro institucionalizado de la Region de Murcia, siendo 12 hombres. Se emplearon los siguientes cuestionarios: Inventario Breve de Inteligencia Emocional para Mayores (EQ-I-M20), Cuestionario de Evaluacion de Calidad de Vida en contexto Residencial (CECAVIR) y la Escala abreviada de Alexitimia de Toronto (TAS-20). Se encontraron correlaciones significativas positivas entre: la dificultad para identificar sentimientos y las relaciones sociales y familiares; la dificultad para identificar sentimientos y satisfaccion con la vida; la dificultad para describir sentimientos y las relaciones sociales y familiares, asi como una correlacion significativa negativa entre dificultad para describir sentimientos y adaptabilidad. Los resultados permitiran avanzar en la implantacion de actividades que promuevan el desarrollo emocional de las personas mayores institucionalizadas en pro de su calidad de vida. EnglishAt the stage of old age it is important the study of emotions and how these affect to adaptation and quality of life of older people. Some authors show up the importance of emotional intelligence and quality of life. Alexithymia refers to the difficulty to understand and identify feelings and those of others and externally oriented thinking. The aim is study the relationship between emotional intelligence, quality of life and alexithymia in a group of elderly. The participants were 25 elderly in an institutionalized center of Murcia; there were 12 men. The questionnaires were used: The brief inventory of emotional intelligence for major (EQ-I-M20), the questionnaire of qualit evaluation of life in residential context (CECAVIR) and The brief scale of alexitimia of Toronto (TAS-20). It found significant positive correlations between: the difficulty to identify feelings and the social and familiar relations; the difficulty to identify feelings and satisfaction with the life; the difficulty to describe feelings and the social and familiar relations as well as a significant negative correlation between difficulty to describe feelings and adaptability. The results will allow to advance in the implantation of activities that promote the emotional development of the elderly institutionalized persons in favor of his quality of life.
Psychosocial and occupational functioning of women in menopause

Cel pracy: Celem pracy była ocena funkcjonowania psychospołecznego i zawodowego kobiet w okresie okołomenopauzalnym poprzez analizę wpływu wybranych czynników społeczno-demograficznych na przebieg menopauzy oraz ich wpływ na jakość życia badanych. Materiał i metoda: Badaniem prospektywnym objęto grupę 256 kobiet w okresie okołomenopauzalnym w przedziale wiekowym 48–58 lat, zamieszkałych w województwie podkarpackim. Narzędzie badawcze stanowiły: indeks Kuppermana, skala depresji Becka oraz skrócona wersja Kwestionariusza jakości życia Światowej Organizacji Zdrowia (World Health Organization Quality of Life – WHOQoL-BREF). Analizę wyników przeprowadzono za pomocą programu Statistica 8.0. Wyniki: Grupa badanych kobiet była jednorodna pod względem wieku. Średni wiek wystąpienia menopauzy wynosił 51,2 roku. Większość respondentek zamieszkiwała wieś, najczęściej z innymi członkami rodziny (średnio 4 osoby). Najliczniejszą grupę stanowiły mężatki. Wśród badanych 56,6% to kobiety aktywne zawodowo, bezrobotne stanowiły 26,3%, emerytki – 11,2%, zaś rencistki – 5,9%. Na wystąpienie objawów menopauzalnych mierzonych wg indeksu Kuppermana mają wpływ trzy zmienne: sytuacja materialna (p = 0,019166), czas od ostatniej miesiączki (p = 0,030078) oraz sytuacja zawodowa badanych (p = 0,00324). W populacji nie zidentyfikowano ciężkiej depresji (mierzonej skalą Becka), natomiast najczęściej stwierdzono brak objawów depresji lub łagodną jej postać. Stopień nasilenia depresji zależał od statusu materialnego (p = 0,00964) badanych oraz ich aktywności seksualnej (p = 0,00324). Jakość życia badanych zależała od statusu zawodowego (p = 0,0000) oraz stosowania hormonoterapii (p = 0,008360). Wnioski: Występujące dolegliwości menopauzalne, niedostateczna sytuacja materialna, niestosowanie terapii hormonalnej, brak satysfakcji z pożycia seksualnego determinują złe funkcjonowanie psychospołeczne i zawodowe, pogarszając jakość życia kobiet w okresie menopauzy. Słowa kluczowe: menopauza, dolegliwości menopauzalne, jakość życia.
Comparing the Effects of Eight Weeks of Combined Training (Endurance and Resistance) in Different Orders on Inflammatory Factors and Adipokines Among Elderly Females

Background: Aging is a process in which the body’s physiological capacity continuously decreases after the age of 30. However, interventions such as physical activity can play an important role in the prevention of aging. Objectives: The purpose of this study was to compare the effects of eight weeks of combined training (endurance and resistance) in different orders on inflammatory factors and adipokines among elderly females. Patients andMethods: The design of this study was quasi-experimental. Forty healthy females were selected purposely and randomly assigned to one of four groups including strength after endurance training (E + S, n = 9), strength prior to endurance training (S + E, n = 10), circulation combined (CI, n = 12), and control (n = 9) groups. The training program was performed for eight weeks, three times per week. Within-group differences were analyzed using a paired samples t-test and between-group differences were analyzed using one-way analysis of variance (ANOVA). Results: The data analysis showed that the between group comparison did not influence the adaptive response of tumor necrosis factor (TNF)-α (P = 0.80), high sensitivity-C reactive protein (hs-CRP) (P = 0.55), adiponectin (P = 0.33), chemerin (P = 0.56), omentin (P = 0.51), leptin (P = 0.10) and vaspin (P = 0.70) levels, yet the within group comparison showed a significant difference in the chemerin concentration in the E+S group (P = 0.03). Conclusions: The results indicated that three different combined trainings (strength and endurance) had no positive effect on inflammatory factors and adipokines among aged females. However, the different combined trainings, independent of order, were effective training methods in reducing body fat and body mass index (BMI) in aged females.
Factors in writing formation in english language clases at Corporación Unificada Nacional de Educación Superior

This project aimed at finding the different influencing situations in the formation of writers in English language classes at Corporación Unificada de Educación Superior (CUN) in Bogotá. The problem came from the contrast of the level of students at writing and the standards appearing in the Common European Framework of Reference for Languages. The methodology is based in the qualitative approach, and the data was collected by means of journals, interviews and surveys. The study evidenced that the different institution factors, the practice from teachers, the routines from students, the relation between reading and writing, among others, influence writing formation.
Relating voices : does voice identify influence degree of relating to the voice and recovery style in people who experience auditory hallucinations

Introduction: Recent government reports indicate that effective caseload management within mental health teams is a priority as greater demands are placed on these services. The present study aimed to assess the convergent validity of a newly devised caseload management tool (MHCET) by comparing it with a reliable and valid clinical measure (CORE). Method: Initially written consent was obtained from all the participants. The MHCET was then completed by psychologists and community psychiatric nurses for fifteen clients and the CORE was completed by the corresponding clients (written consent was obtained). Data was collected from clients accessing primary care and community mental health team services to obtain a broad range of feedback. Results: Correlations were carried out between the MHCET and the CORE and the results indicated a significant relationship between the overall scores of the two measures. Certain domains of the MHCET correlated very highly with the CORE. Comparison of scores between the two levels of service did not indicate a significant difference with respect to case complexity. Discussion: Due to the low response rate results were interpreted with caution, although a positive trend was observed between the two measures. Reasons for the low response rate were discussed. Feedback from clinicians indicated that the research would be too time consuming. Further issues, including relevance to the service and perceived threat of the research, were also discussed.
The Role of Differential Experience in Facial Age Processing

The present study investigated the role of differential experience in one’s processing of facial age information. Study 1 examined how differential experience with ownand other-race individuals, as well as differential experience with ownand other-age individuals, influences children’s and adults’ abilities to process facial age information. Study 2 examined how differential sociocultural experiences influence adults’ abilities to process facial age information. The results suggest that the influence of differential experience with ownand other-race faces is most evident when individuals have extremely limited to no experience with other-race faces. There was also a clear other-age effect in young adults’ facial age judgments, presumably due to their extensive experience with own-age peers. However 9to 10-year-olds and 13to 14-year-olds also showed an advantage in processing facial age information for young adult faces relative to child and middle-age adult faces. Thus, the 9to 10-year-olds and 13to 14-year-olds may have also had the most extensive experience with young adult individuals relative to individuals from other age groups. In addition, results suggest that the efficiency with which individuals process facial age information is influenced by differential sociocultural emphases on the need to differentiate between the facial ages of social partners.
Teacher job satisfaction: the importance of school working conditions and teacher characteristics

ABSTRACT Given that teacher shortage is an international problem, teacher job satisfaction merits closer attention. Not only is job satisfaction closely related to teacher retention, but it also contributes to the well-being of teachers and their students, overall school cohesion and enhanced status of the teaching profession. This study investigates the relations between teacher job satisfaction, school working conditions and teacher characteristics for eighth grade mathematics teachers. The study employs TIMSS 2015 (Trends in International Mathematics and Science Study) data from Sweden. Confirmatory factor analysis and structural equation modelling are used as main methods. Results demonstrate a substantial association between school working conditions and teacher job satisfaction. More specifically, teacher workload, teacher cooperation and teacher perceptions of student discipline in school were the factors most closely related to teacher job satisfaction. As to teacher characteristics, female teachers, teachers with more exposure to professional development and more efficacious teachers tended to have higher levels of job satisfaction. In addition, it was found that the relationship between the extent of teacher cooperation and job satisfaction was more pronounced for male teachers, while student discipline was more important for job satisfaction of teachers with lower self-efficacy beliefs. Implications for policy are further discussed.
Analysis of the primary and post-treatment antibiotic resistance of Helico-bacter pylori in Nanjing area.

BACKGROUND Resistance of Helicobacter pylori（H. pylori） to antibiotics is increasing worldwide. In order to understand the current situation of antibiotic resistance in Nanjing and provide a reasonable basis for clinical selection of antibiotics to cure H. Pylori. OBJECTIVE To investigate the current status of H. Pylori antibiotics resistance in Nanjing area, and analyze the primary and post-treatment antibiotic resistance of H. pylori in this area. METHODS During the period from July 2017 to December 2019, 1533 gastric mucosal specimens from patients with positive H. pylori confirmed by breath test or rapid urease test were collected for isolation and identify H. pylori. The agar dilution method was used for antibiotic resistance test. RESULTS The result showed that the resistance rates of H. pylori to amoxicillin, clarithromycin, levofloxacin, furazolidone, tetracycline and metronidazole were 2.74%, 47.03%, 33.59%, 0.91%, 0.52% and 80.76%, respectively in the period of July 2017 to December 2019. The resistance rates of H. pylori (primary Vs post-treatment) to amoxicillin, clarithromycin, levofloxacin, furazolidone, tetracycline and metronidazole were 1.83% Vs 6.08%, 38.62% Vs 77.81%, 27.41% Vs 56.23%, 0.58% Vs 2.13%, 0.33% Vs 1.22%, 78.57% Vs 88.75%, respectively. CONCLUSIONS Antibiotic resistance of H. pylori remained a problem for the effective eradication of this pathogen and its associated diseases in Nanjing area. For post-treatment eradication patients, clinicians should took into account regional antibiotic resistance rate, personal antibiotic exposure history, economic benefit ratio, adverse antibiotic reactions, antibiotic availability and other aspects．.
Addition of Compound Kushen Injection to Vinorelbine Plus Cisplatin for Patients with Non-small Cell Lung Cancer: Clinical Observation

OBJECTIVE:To evaluate the efficacy and safety of complound Kushen injection combined with chemotherapy in patients with advanced nonsmall-cell lung cancer(NSCLC). METHODS: A total of 106 NSCLC patients were randomly assigned to either control group(receiving chemotherapy alone) or trial group(with add-on compound Kushen injection). The chemotherapy(NP chemotherapy) consisted of vinorelbine(NVB) 25 mg·m-2 on day 1 and day 8 plus cisplatin(DDP) 25 mg·m-2 from day 1 to day 3 by intravenous drip infusion for 2 cycles(1 cycle was defined as treatment of 21 days). RESULTS: The treatment group was superior to the control group in short-term response rate,KPS score,pain management and adverse reaction(P0.05). CONCLUSION: Addition of Kushen injection to NP chemotherapy resulted in stable curative efficacy,improved short-term response rate,attenuated side effects and improved quality of life in patients with NSCLC.