Miracle-dz/UniFAR-FTUs huggingface dataset:
Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent

RRx-001 has shown promise as a novel cancer therapeutic agent. The disposition of RRx-001 was evaluated in vitro and after intravenous administration to rats. At both 24 and 168 h after a single intravenous administration of 14C-RRx-001 (10 mg/kg), the majority of radiolabel was in the blood. The recovery of label in excreta was quite low, but the major route of radiolabel excretion was via the kidney, with approximately 26% in the urine by the first 8 h and decreasing amounts in all subsequent collections to a total of 36.3% by 168 h. The partitioning of total radioactivity in red blood cells (RBCs) and plasma was determined after in vitro addition to human, rat, dog, and monkey whole blood at 1 and 20 μM. In rat, at 30 min, approximately 75% of the radioactivity is associated with RBCs and 25% with plasma. In human, at 30 min, approximately 25% of the radioactivity is associated with RBCs and 75% with plasma. Analysis by liquid chromatography/radiodetection/mass spectrometry showed that 14C-RRx-001 reacted rapidly with whole blood to give four major soluble metabolites: the GSH and Cys adducts of RRx-001 (M1 and M2) and the corresponding mononitro GSH and Cys adducts (M3 and M4). Human Hb was incubated with cold RRx-001 in buffer, and a standard proteomics protocol was used to separate and identify the tryptic peptides. Standard peptide collision-induced fragment ions supported the structure of the peptide GTFATLSELHCDK with the alkylation on the Cys-93 locus of the Hb β chain.
A converse theorem for double Dirichlet series and Shintani zeta functions

The main aim of this paper is to obtain a converse theorem for double Dirichlet series and use it to show that the Shintani zeta functions which arise in the theory of prehomogeneous vector spaces are actually linear combinations of Mellin transforms of metaplectic Eisenstein series on GL (2). The converse theorem we prove will apply to a very general family of double Dirichlet series which we now define.
Gheorghe Asachi ” Technical University of Iasi , Romania BIOGAS PRODUCTION FROM WHEAT STRAW PRETREATED WITH LIGNINOLYTIC FUNGI AND CO-DIGESTION WITH PIG SLURRY

This study carried out for the first time a comparison among ligninolytic (white-rot) and cellulosolytic or xylanolytic (Trichoderma) pre-treated wheat straw, for biogas production, potential, without or with pig slurry in co-digestion. Methane (CH4) production from wheat straw pre-treated for 4 and 10 weeks with seven different fungal isolates was preliminarily measured. Then, the effects on biogas yield of the co-digestion with pig slurry were checked on straw pre-treated with 3 selected fungal strains. The maximum production of CH4 from pre-treated straw with Ceriporiopsis subvermispora (SUB) for 4 and 10 weeks was higher than the control (16% and 37%, respectively). The accumulation daily rate was higher than control (42% and 81%, respectively). A positive correlation between CH4 accumulation daily rate and straw enzymatic digestibility was found. In co-digestion with pig slurry, SUB pre-treated straw for 10 weeks showed an accumulation daily rate of 17.4 mL d g VS, significantly higher (17%) than that of the control. The time to reach the maximum CH4 production was shortened on average from 34 to 21 days in co-digestion with pig slurry, in comparison with pre-treated mono-digested wheat straw. The biological pre-treatment with selected white-rot fungi appears a promising technology to increase methane production from wheat straw.
Teleoperation in Presence of Uncertainties: A Constraint-Based Approach

Abstract The application of teleoperation systems in the medical field demands for techniques that allow to add task constraints on top of (bilateral) teleoperation. How to blend these additional constraints into the control description of a teleoperation system remains a challenge. This paper shows how to realize a position-position and a position-force teleoperation scheme with additional task constraints using iTaSC. In particular, it shows how motion compensation, employing the estimate of such motion, can be achieved. As a case study, a periodical motion compensation for a simulated beating heart is implemented. The estimation of this periodical motion is based only on the position measurement of the end-effector of the slave robot, without using a camera or force sensor. Moreover, this paper presents an approach to gradually increase/decrease the motion compensation depending on the confidence in the estimated motion.
Integrating Algae with Bioenergy Carbon Capture and Storage (ABECCS) Increases Sustainability

Bioenergy carbon capture and storage (BECCS) has been proposed to reduce atmospheric CO2 concentrations, but concerns remain about competition for arable land and freshwater. The synergistic integration of algae production, which does not require arable land or freshwater, with BECCS (called “ABECCS”) can reduce CO2 emissions without competing with agriculture. This study presents a technoeconomic and life‐cycle assessment for colocating a 121‐ha algae facility with a 2,680‐ha eucalyptus forest for BECCS. The eucalyptus biomass fuels combined heat and power (CHP) generation with subsequent amine‐based carbon capture and storage (CCS). A portion of the captured CO2 is used for growing algae and the remainder is sequestered. Biomass combustion supplies CO2, heat, and electricity, thus increasing the range of sites suitable for algae cultivation. Economic, energetic, and environmental impacts are considered. The system yields as much protein as soybeans while generating 61.5 TJ of electricity and sequestering 29,600 t of CO2 per year. More energy is generated than consumed and the freshwater footprint is roughly equal to that for soybeans. Financial break‐even is achieved for product value combinations that include 1) algal biomass sold for $1,400/t (fishmeal replacement) with a $68/t carbon credit and 2) algal biomass sold for $600/t (soymeal replacement) with a $278/t carbon credit. Sensitivity analysis shows significant reductions to the cost of carbon sequestration are possible. The ABECCS system represents a unique technology for negative emissions without reducing protein production or increasing water demand, and should therefore be included in the suite of technologies being considered to address global sustainability.
Alpha/sim simulation software tutorial

ALPHA/Sim is a general-purpose, discrete-event simulation tool. ALPHA/Sim allows a user to graphically build a simulation model, enter input data via integrated forms, execute the simulation model, and view the simulation results, within a single graphical environment. In this paper, we introduce ALPHA/Sim and describe how to use ALPHA/Sim to build, simulate, and analyze a simple manufacturing system. In addition, we briefly describe some advanced features and list some sample applications.
SOA-Based Integration of the Internet of Things in Enterprise Services

Advances in the areas of embedded systems, computing, and networking are leading to an infrastructure composed of millions of heterogeneous devices. These devices will not simply convey information but process it in transit, connect peer to peer, and form advanced collaborations. This ``Internet of Things'' infrastructure will be strongly integrated with the environment, and its integration with the enterprise systems will not only further blur the line between business IT systems and the real world, but will change the way we design, deploy, and use services. New opportunities can emerge for businesses, which can now closely collaborate with the real world. The work presented here proposes an architecture for an effective integration of the Internet of Things in enterprise services.
KLEIN: A Minimally Disruptive Design for an Elastic Cellular Core

Today's cellular core, which connects the radio access network to the Internet, relies on fixed hardware appliances placed at a few dedicated locations and uses relatively static routing policies. As such, today's core design has key limitations---it induces inefficient provisioning tradeoffs and is poorly equipped to handle overload, failure scenarios, and diverse application requirements. To address these limitations, ongoing efforts envision "clean slate" solutions that depart from cellular standards and routing protocols; e.g., via programmable switches at base stations and per-flow SDN-like orchestration. The driving question of this work is to ask if a clean-slate redesign is necessary and if not, how can we design a flexible cellular core that is minimally disruptive. We propose KLEIN, a design that stays within the confines of current cellular standards and addresses the above limitations by combining network functions virtualization with smart resource management. We address key challenges w.r. t. scalability and responsiveness in realizing KLEIN via backwards-compatible orchestration mechanisms. Our evaluations through data-driven simulations and real prototype experiments using OpenAirInterface show that KLEIN can scale to billions of devices and is close to optimal for wide variety of traffic and deployment parameters.
Atypical antipsychotics in bipolar disorder: the treatment of mania

Mania is a clearly defined condition that can present in different levels of severity, varying from the mild (hypomanic) to the florid, raging and psychotic. Only the mildest forms can be left untreated without risking harm to either the patient’s welfare, relationships and job, or to the well-being of those who are close to them (relatives, carers and mental health professionals). The milder forms may be accompanied by high levels of energy, productivity and creativity. But even these carry a risk of subsequently switching into a phase of depression and incapacity that might have been avoided by treatment of the preceding hypomania. Severe forms constitute a psychiatric emergency, demanding immediate control, including rapid tranquillisation with medication. Mania is one of the most insightless forms of mental disorder and for treatment to be very useful it must be not only effective but also acceptable to the patient, easy to use and not produce unpleasant side-effects (Cookson, 2007). Surveys of clinical practice have shown that antipsychotics are the most commonly used drugs for patients hospitalised with mania, whether in Britain, Scandinavia, other parts of Europe or North America. Classical (typical) antipsychotics produce unpleasant extrapyramidal side-effects such as akathisia, dystonia and parkinsonism, which (although partially preventable by anticholinergic medication) are resented by patients and limit their adherence to treatment. It is therefore very important to know whether the use of antipsychotics in mania is justified by evidence of efficacy and whether newer antipsychotics with fewer unpleasant acute side-effects are also effective in mania.
Adjunctive Medical Therapies for Acute Stroke Thrombolysis: Is There a CLEAR-ER Choice?

See related article, p 2381 Beyond intravenous tissue-type plasminogen activator (IV-tPA), the field of acute ischemic stroke suffers from a lack of safe and effective treatments aimed at both proximal thrombus dissolution and return of flow to the microcirculation. Larger thrombi have notoriously proven to be resistant to IV-tPA lysis with recanalization rates in the range of only 13% to 20%. 1,2 Even if endovascular treatment of ischemic stroke is proven to improve clinical outcomes, there will still be many patients with residual partial or complete occlusion after IV-tPA alone suffering ischemia, whereas waiting for catheter rescue. The lag between endovascular team activation and groin puncture requires precious minutes-to-hours for team assembly. For example, in the Interventional Management of Stroke-3 clinical trial, the average time from tPA bolus to intraarterial therapy was 2.2 hours.3 Therefore, development of combination therapies for acute ischemic stroke that can be delivered quickly in the emergency setting is crucial. Adjunctive therapies to IV-tPA can take many forms to include medical or mechanical, but any of these must be started early to augment the effect of IV-tPA.4 Ongoing strategies that are in either phase II or III clinical trials include thrombin-inhibition, sonothrombolysis, and platelet-inhibition. In this issue of Stroke , the results of the Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke–Enhanced Regimen (CLEAR-ER) study are published.5 This is a multicenter, double-blind, randomized phase II safety trial of 0.9 mg/kg 0 to 3 hours IV-tPA versus 0.6 mg/kg 0 to 3 hours IV-tPA+IV eptifibatide (bolus 135 mcg/kg and 2-hour infusion at 0.75 mcg/kg per minute). CLEAR-ER sought to estimate the safety and efficacy of combination GP Ib/IIIa+reduced dose IV-tPA when delivered to hyperacute ischemic stroke. The trial was sponsored by the National Institutes of Health/National Institute of …
Draft Genome Sequence of Chloracidobacterium sp. CP2_5A, a Phototrophic Member of the Phylum Acidobacteria Recovered from a Japanese Hot Spring

ABSTRACT The phylum Acidobacteria contains a single known phototrophic member, Chloracidobacterium thermophilum, which was recovered from a hot spring metagenome from Yellowstone National Park. Here, we expand the diversity of the genus Chloracidobacterium with a genome recovered from a hot spring in Japan, extending the known range of this lineage to a new continent.
On the significance of cluster-temporal browsing for generic video retrieval: a statistical analysis

In this paper, we test statistically the effect of content-based browsing in generic video retrieval. Using TRECVID 2004 and 2005 experiments, we demonstrate that content-based browsing improves retrieval over sequential queries and relevance feedback. Two user groups, novices and system developers have been used in the experiments on large and multilingual video collections. Novice users were found to achieve improvement in search effectiveness with cluster-temporal browsing by statistically significant amount. System developers did not have statistically significant difference between the different system configurations.
Unique Stability Point in Social Storage Networks

We model social storage systems as a strategic network formation game. We define the utility of each player in the network under two different frameworks, one where the cost to add and maintain links is considered in the utility function and the other where budget constraints are considered. In the context of social storage and social cloud computing, these utility functions are the first of its kind, and we use them to define and analyze the social storage network game. We, then, present the pairwise stability concept adapted for social storage where both addition and deletion of links require mutual consent, as compared to mutual consent just for link addition in the pairwise stability concept defined by Jackson and Wolinsky [35]. Mutual consent for link deletion is especially important in the social storage setting. For symmetric storage networks, we prove that there exists a unique neighborhood size, independent of the number of players, where no pair of users has any incentive to increase or decrease their neighborhood size. We call this neighborhood size as the stability point. We provide some necessary and sufficient conditions for pairwise stability of social storage networks. Further, given the number of players and other parameters, we discuss which pairwise stable networks would evolve. We also show that in a connected pairwise stable network there can be at most one player with neighborhood size one less than (or one more than) the stability point.
Comparative Phosphoproteomics Reveals Components of Host Cell Invasion and Post-transcriptional Regulation During Francisella Infection*

Francisella tularensis is a facultative intracellular bacterium that causes the deadly disease tularemia. Most evidence suggests that Francisella is not well recognized by the innate immune system that normally leads to cytokine expression and cell death. In previous work, we identified new bacterial factors that were hyper-cytotoxic to macrophages. Four of the identified hyper-cytotoxic strains (lpcC, manB, manC, and kdtA) had an impaired lipopolysaccharide (LPS) synthesis and produced an exposed lipid A lacking the O-antigen. These mutants were not only hyper-cytotoxic but also were phagocytosed at much higher rates compared with the wild type parent strain. To elucidate the cellular signaling underlying this enhanced phagocytosis and cell death, we performed a large-scale comparative phosphoproteomic analysis of cells infected with wild-type and delta-lpcC F. novicida. Our data suggest that not only actin but also intermediate filaments and microtubules are important for F. novicida entry into the host cells. In addition, we observed differential phosphorylation of tristetraprolin, a key component of the mRNA-degrading machinery that controls the expression of a variety of genes including many cytokines. Infection with the delta-lpcC mutant induced the hyper-phosphorylation and inhibition of tristetraprolin, leading to the production of cytokines such as IL-1beta and TNF-alpha that may kill the host cells by triggering apoptosis. Together, our data provide new insights for Francisella invasion and a post-transcriptional mechanism that prevents the expression of host immune response factors that control infection by this pathogen.
PUFKEY: A High-Security and High-Throughput Hardware True Random Number Generator for Sensor Networks

Random number generators (RNG) play an important role in many sensor network systems and applications, such as those requiring secure and robust communications. In this paper, we develop a high-security and high-throughput hardware true random number generator, called PUFKEY, which consists of two kinds of physical unclonable function (PUF) elements. Combined with a conditioning algorithm, true random seeds are extracted from the noise on the start-up pattern of SRAM memories. These true random seeds contain full entropy. Then, the true random seeds are used as the input for a non-deterministic hardware RNG to generate a stream of true random bits with a throughput as high as 803 Mbps. The experimental results show that the bitstream generated by the proposed PUFKEY can pass all standard national institute of standards and technology (NIST) randomness tests and is resilient to a wide range of security attacks.
The expression problem, trivially!

This paper presents a novel and simple solution to Wadler’s Expression Problem that works in conventional object-oriented languages. Unlike all existing solutions in Java-like languages, this new solution does not use any kind of generics: it relies only on subtyping. The key to the solution is the use of covariant type refinement of return types (or fields): a simple feature available in many object-oriented languages, but not as widely known or used as it should be. We believe that our results present valuable insights for researchers and programming language designers interested in extensibility. Furthermore our results have immediate applicability as practical design patterns for programmers interested in improving extensibility of their programs.
A Hardware Accelerator for the Fast Retrieval of DIALIGN Biological Sequence Alignments in Linear Space

The recent and astonishing accomplishments in the field of Genomics would not have been possible without the techniques, algorithms, and tools developed in Bioinformatics. Biological sequence comparison is an important operation in Bioinformatics because it is used to determine how similar two sequences are. As a result of this operation, one or more alignments are produced. DIALIGN is an exact algorithm that uses dynamic programming to obtain optimal biological sequence alignments in quadratic space and time. One effective way to accelerate DIALIGN is to design FPGA-based architectures to execute it. Nevertheless, the complete retrieval of an alignment in hardware requires modifications on the original algorithm because it executes in quadratic space. In this paper, we propose and evaluate two FPGA-based accelerators executing DIALIGN in linear space: one to obtain the optimal DIALIGN score (DIALIGN-Score) and one to retrieve the DIALIGN alignment (DIALIGN-Alignment). Because it appears to be no documented variant of the DIALIGN algorithm that produces alignments in linear space, we here propose a linear space variant of the DIALIGN algorithm and have designed the DIALIGN-Alignment accelerator to implement it. The experimental results show that impressive speedups can be obtained with both accelerators when comparing long biological sequences: the DIALIGN-Score accelerator achieved a speedup of 383.4 and the DIALIGN-Alignment accelerator reached a speedup of 141.38.
The FLERSA tool: adding semantics to a web content management system

Purpose – Nowadays, the use of WCMS (web content management systems) is widespread. The conversion of this infrastructure into its semantic equivalent (semantic WCMS) is a critical issue, as this enables the benefits of the semantic web to be extended. The purpose of this paper is to present a FLERSA (Flexible Range Semantic Annotation) for flexible range semantic annotation.Design/methodology/approach – A FLERSA is presented as a user‐centred annotation tool for Web content expressed in natural language. The tool has been built in order to illustrate how a WCMS called Joomla! can be converted into its semantic equivalent.Findings – The development of the tool shows that it is possible to build a semantic WCMS through a combination of semantic components and other resources such as ontologies and emergence technologies, including XML, RDF, RDFa and OWL.Practical implications – The paper provides a starting‐point for further research in which the principles and techniques of the FLERSA tool can be applied .
Early supplies of available nitrogen to the seed-row as affected by fertilizer placement

A field experiment was conducted at Star City, (legal location SW6-45-16-W2); Saskatchewan, Canada from May to June 2000, to measure N and P supply rates from fertilizer band to canola seed row. Ion exchange resin membrane probes (PRS) were used to measure nutrient supply rates in four treatments (80 kg/ha of urea side-band, 80 kg/ha of urea mid-row band, check/no N (side-row)/P side-banded, check/no N (mid-row)/P seed placed. The treatments were arranged in a randomized complete block design with four replications. Two anion and cation exchange resin probes (PRS) were placed in each plot in the seed-row immediately after seeding and fertilizing. The probes were allowed to remain in the field for 2 days and replaced with another set of probes every 4 days for a total of 14 days until canola emerged. Ammonium-N, nitrate-N and P supply rates were calculated based on the ion accumulated on the probes. Grain and straw yield were measured in each plot. Urea side-row band treatments had significantly higher cumulative available N supply rates than mid-row banded placement. No significant differences were observed in P supply rates. The higher N rates (120 kg N/ha) showed lower grain yield in side banding than mid-row banding treatment possibly due to seedling damage, however the earlier fluxes of N into the seed-row observed with side-banding may be an advantage at lower N rates in N deficient soils.