Miracle-dz/UniFAR-FTUs huggingface dataset:
What Zebrafish and Nanotechnology Can Offer for Cancer Treatments in the Age of Personalized Medicine

Simple Summary Discovering new strategies for cancer treatment is critical, considering that each year millions of deaths are caused by this disease. In this sense, therapies based on nanomedicine are an innovative approach for cancer treatment, not only because they make it possible to perform targeted therapy, but also because they can improve patients’ quality of life. A key step to transfer new treatments from bench to beside is in vivo evaluation of a therapy, where zebrafish as a model organism has a fundamental role. Zebrafish has several benefits that make it ideal for studying the therapeutic capacity of novel nanotechnology-based anticancer therapies. In this review, we evaluate the potential of the nanomedicine and zebrafish synergy to achieve personalized treatments for cancer. Abstract Cancer causes millions of deaths each year and thus urgently requires the development of new therapeutic strategies. Nanotechnology-based anticancer therapies are a promising approach, with several formulations already approved and in clinical use. The evaluation of these therapies requires efficient in vivo models to study their behavior and interaction with cancer cells, and to optimize their properties to ensure maximum efficacy and safety. In this way, zebrafish is an important candidate due to its high homology with the human genoma, its large offspring, and the ease in developing specific cancer models. The role of zebrafish as a model for anticancer therapy studies has been highly evidenced, allowing researchers not only to perform drug screenings but also to evaluate novel therapies such as immunotherapies and nanotherapies. Beyond that, zebrafish can be used as an “avatar” model for performing patient-derived xenografts for personalized medicine. These characteristics place zebrafish in an attractive position as a role model for evaluating novel therapies for cancer treatment, such as nanomedicine.
Ultrasonography guided supraclavicular brachial plexus block: comparison of sensori-motor blockade and duration of postoperative analgesia between ropivacaine and levo-bupivaine

The study was conducted to compare the onset time, duration and quality of analgesia between 0.5% levo-bupivacaine and 0.5% ropivacaine given in brachial plexus. This prospective, triple blind randomized controlled trial was conducted between January 2020 to December 2021. Seventy patients were randomly allocated into two groups of 35 patients each to receive USG guided brachial plexus block with 30 ml of 0.5% levo-bupivacaine or 30 ml of 0.5%ropivacaine. Blinded observer recorded the onset time and duration of brachial plexus block. Patient characteristics regarding age, weight, and surgical time were comparable in the two groups. The mean onset time of sensory blockade with 0.5% ropivacaine and 0.5%levo-bupivacaine was clinically comparable in our present study. The mean duration of sensory block with 0.5% ropivacaine and 0.5% levo-bupivacaine was also comparable in study. The mean onset time for motor block with 0.5%levo-bupivacaine was lesser than 0.5% ropivacaine. The mean duration of motor block observed in present study with 0.5% ropivacaine was lesser than 0.5% levo-bupivacaine. Mean duration of post operative analgesia of 485.0 ± 76.90 mins (8.08 hrs) was noted with 0.5%ropivacaine and 491.91 ± 92.99 mins (8.2 hrs) with 0.5%levo-bupivacaine which was clinically comparable and the difference was statistically insignificant.
The Relationship between Learning Style toward Mastery of Concepts and Problem Solving Skill Introduction to Nuclear Physics for Pre-Service Teacher

Many factors that influence the students’ learning achievement include the learning styles. If the teacher presents learning according to the student's learning style, it will have an impact on maximum student learning outcomes. Student learning outcomes could be in the form of problem solving skills and mastery of students' preliminary concepts of nuclear physics. Problem solving ability is an important ability that must be possessed by students in facing the era of the industrial revolution 4.0. Therefore, the purpose of this study was to obtain an overview of learning styles, problem solving abilities and mastery of student teacher concepts for this physics introduction. The method used in this research was a case study with a sample of 35 physics teacher candidates at a private university in the city of Palembang. The learning applied is traditional learning with interactive multimedia-assisted presentation method. The results showed that the predominant primary learning style of nuclear physics students was auditory, while the average problem-solving ability and mastery of preliminary nuclear physics concepts were 89 and 93, respectively, with very high categories. The results of this study become input in the development of the nuclear physics preliminary lecture.
Assessing Microbial Corrosion Risk on Offshore Crude Oil Production Topsides under Conditions of Nitrate and Nitrite Treatment for Souring

Oilfield souring is a detrimental effect caused by sulfate-reducing microorganisms that reduce sulfate to sulfide during their respiration process. Nitrate or nitrite can be used to mitigate souring, but may also impart a corrosion risk. Produced fluids sampled from the topside infrastructure of two floating, production, storage, and offloading (FPSO) vessels (Platform A and Platform B) were assessed for microbial corrosion under nitrate and nitrite breakthrough conditions using microcosm tests incubated at 54 °C. Microbial community compositions on each individual FPSO were similar, while those between the two FPSO vessels differed. Platform B microbial communities responded as expected to nitrate breakthrough conditions, where nitrate-reducing activity was enhanced and sulfate reduction was inhibited. In contrast, nitrate treatments of Platform A microbial communities were not as effective in preventing sulfide production. Nitrite breakthrough conditions had the strongest sulfate reduction inhibition in samples from both platforms, but exhibited the highest pitting density. Live experimental replicates with no nitrate or nitrite additive yielded the highest general corrosion rates in the study (up to 0.48 mm/year), while nitrate- or nitrite-treated fluids revealed general corrosion rates that are considered low or moderate (<0.12 mm/year). Overall, the results of this study provide a description of nitrogen- and sulfur-based microbial activities under thermophilic conditions, and their risk for MIC that can occur along fluid processing lines on FPSO topsides that process fluids during offshore oil production operations.
Predictors of nursing home placement at 2 years in Alzheimer's disease: A follow‐up survey from the THERAD study

Nursing Home Placement (NHP) can prove to be the only solution to some dead‐end situations in Alzheimer's disease (AD). The predictors of NHP are known and can be related to either the person with dementia or his/her caregiver. We aimed to identify predictors of NHP among people with AD over a 2‐year follow‐up period, with a particular interest in the modifiable predictors, notably those involving caregivers.
Prevalence and Associated Risk Factors of Endoparasites among Under-Five Children in Debre Tabor Comprehensive Specialized Hospital, Debre Tabor, Northwest Ethiopia: A Cross-Sectional Study

Many endoparasites are still considered neglected tropical illnesses. The term “endoparasites” refers to infections caused by both helminths and protozoa. In many places in Ethiopia, particularly Debre Tabor, epidemiological data on the prevalence and associated variables of endoparasites among under-five children is unavailable. Thus, the aim of this study was to gather baseline data on the prevalence of endoparasites and their associated variables among under-five children who visited the Debre Tabor comprehensive specialized hospital in Northwest Ethiopia. A hospital-based quantitative cross-sectional study was used. The study was carried out from May 1 to November 30, 2021. Study participants were selected by a systematic sampling technique. The stool specimen was examined for the presence of different stages of intestinal parasites (adult, trophozoite, larvae, cysts, and ova) using direct wet mount, modified formal-ether sedimentation, and modified Ziehl–Neelsen methods. The IBM SPSS statistical package (version 23) was used to enter and analyze the collected data. The data was summarized using frequency tables and a bar chart. The adjusted odds ratio and p value <0.05 were used to declare the final association. In the present study, a total of 258 under-five children and their mothers/guardians were involved in the study, with a response rate of 100%. More than half of the respondents, 137 (53.10%), were females, and 159 (61.63%) were in the age group of 24 to 59 months. The overall prevalence of one or more endoparasites among under-five children was 45 (17.44%). Multivariate logistic regression analysis showed that health supervision, child food freshness, regular trimming of fingernails, and children's playground cleanliness were significantly associated with childhood endoparasites. The present study demonstrated a higher prevalence of endoparasites among under-five children. Health supervision, child food freshness, regular trimming of fingernails, and children's playground cleanliness were significantly associated with endoparasites. Thus, strengthening health education about food, personal, and environmental hygiene for both children and their mothers/guardians is crucial.
Knowledge and Practices of Oral Health Status among Pregnant Women Attending Liaquat University Hospital Jamshoro

Background: Pregnant women's oral health behaviors and attitudes are infrequently studied in low-income countries, but they should be taken into account when developing preventive or therapeutic research to lessen the load of oral illnesses. Objective: To assess the knowledge and practices of oral health in pregnant women attending Oral diagnosis outpatient department OPD of Liaquat university hospital Jamshoro. Subject and Methods: A total of 150 patients were included in the study. Data was collected by providing questionnaire to pregnant women who attended OPD for their antenatal check up. Socidemographic findings, questions related to participant’s knowledge regarding oral health and practices adopted were recorded. Results: Most of the patients, 49.3% were in age range of 26 to 35 years with the majority of them being housewives. A total of 48% were illiterate followed by 24.6% who had only just primary education. Around 51.3% have the good habit of brushing twice a day. Only 37.3% had knowledge about nutritional implications in pregnancy, and 34% visit dentist once in six months. Conclusion: The majority of patients has little or average knowledge regarding oral health in pregnancy.
CONVERGENCE ANALYSIS OF FINE PARTICULATE (PM2.5) CONCENTRATIONS FOR 212 TO 108 COUNTRIES

Two measures of fine particulate matter, PM2.5 exposure and exceedance are used to analyze convergence patterns of 212 and 108 countries during the period of 2000 to 2014. For exposure, sigma index diverges at the annual rate of +1.07%, while gamma index converges at -0.5% rate. For exceedance, sigma index also diverges at +1.24%, while gamma index converges at -1.22%. The results from income and regional subgroups also indicate that lagging countries are catching-up to leading countries throughout the period in each subgroup. Policy implications from these finding will be discussed.
Melawan Korupsi

Refleksi teologis ini hendak memberi pesan bagi orang Kristen dengan menelaah korupsi berdasarkan Injil Matius 6: 11 di tengah menjamurnya korupsi di Indonesia. Melalui metode kepustakaan, artikel ini menemukan bahwa Matius 6: 11 menentang korupsi sebab korupsi merupakan bentuk ketidakpedulian merawat iman sosial yang diwariskan Yesus, yaitu sikap sadar dan peduli pada kebutuhan sesama sebagaimana tercermin dalam seruan “makanan kami” dan “secukupnya”. Berdasarkan temuan tersebut, artikel ini sampai pada alternatif solusi, yaitu menggalang pendidikan antikorupsi secara informal dan formal. Secara informal, orang tua diajak untuk membangun teladan hidup jujur sebagai habitus keluarga dan menjadikan rumah sebagai sekolah iman. Secara formal, perlu dilakukan integrasi nilai-nilai antikorupsi ke dalam sejumlah mata pelajaran atau mata kuliah (pendekatan inklusif) dan menjadikan pendidikan antikorupsi sebagai mata pelajaran muatan lokal atau mata kuliah tersendiri (pendekatan eksklusif).
Socializing Targets of Older Adults’ SNS Use: Social Strain Mediates the Relations Between Older Adults’ SNS Use With Friends and Well-Being Outcomes

Studies have yielded mixed findings regarding the relation between older adults’ social networking site (SNS) use and well-being. Drawing on socioemotional selectivity theory, we sought to examine whether older adults’ SNS use with different socializing targets (i.e., family vs friends) would differentially predict global, social, and mental well-being outcomes indexed by life satisfaction, loneliness, and depressive symptoms, respectively. Furthermore, we examined whether social support and social strain would mediate, in parallel, the relations between SNS use and well-being outcomes. We recruited healthy, community-dwelling older adults (ages 60–93 years, N = 69). Using the PROCESS macro, we found that SNS use with friends, but not family, predicted poorer life satisfaction and greater loneliness via increased social strain. However, SNS use with neither friends nor family was linked to depressive symptoms. Furthermore, social support failed to account for the relations between SNS use and well-being indices. These results held when we controlled for a host of covariates—age, gender, education level, income, marital status, and overall physical health. Our findings reconcile disparate findings in the literature by elucidating that older adults’ SNS use with different socializing targets asymmetrically predicts life satisfaction and loneliness via varying degrees of perceived social strain.
Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders

It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders. Meanwhile, epoxy fatty acids such as epoxyeicosatrienoic acids (EETs), epoxyeicosatetraenoic acids (EEQs), and epoxyeicosapentaenoic acids (EDPs) have been found to exert neuroprotective effects in animal models of neuropsychiatric disorders through potent anti-inflammatory actions. Soluble expoxide hydrolase, an enzyme present in all living organisms, metabolizes epoxy fatty acids into the corresponding dihydroxy fatty acids, which are less active than the precursors. In this regard, preclinical findings using sEH inhibitors or Ephx2 knock-out (KO) mice have indicated that the inhibition or deficiency of sEH can have beneficial effects in several models of neuropsychiatric disorders. Thus, this review discusses the current findings of the role of sEH in neuropsychiatric disorders, including depression, autism spectrum disorder (ASD), schizophrenia, Parkinson’s disease (PD), and stroke, as well as the potential mechanisms underlying the therapeutic effects of sEH inhibitors.
Higher BNP/NT‐pro BNP levels stratify prognosis equally well in patients with and without heart failure: a meta‐analysis

The initial and dynamic levels of B‐type natriuretic peptide (BNP) and N‐terminal‐prohormone BNP (NT‐proBNP) are routinely used in clinical practice to identify patients with acute and chronic heart failure. In addition, BNP/NT‐proBNP levels might be useful for risk stratification in patients with and without heart failure. We performed a meta‐analysis to investigate, whether the value of BNP/NT‐proBNP as predictors of long‐term prognosis differentiates in cohorts with and without heart failure.
Security assessment of open source third-parties applications

Free and Open Source Software (FOSS) components are ubiquitous in both proprietary and open source applications. In this dissertation we discuss challenges that large software vendors face when they must integrate and maintain FOSS components into their software supply chain. Each time a vulnerability is disclosed in a FOSS component, a software vendor must decide whether to update the component, patch the application itself, or just do nothing as the vulnerability is not applicable to the deployed version that may be old enough to be not vulnerable. This is particularly challenging for enterprise software vendors that consume thousands of FOSS components, and offer more than a decade of support and security fixes for applications that include these components. First, we design a framework for performing security vulnerability experimentations. In particular, for testing known exploits for publicly disclosed vulnerabilities against different versions and software configurations. Second, we provide an automatic screening test for quickly identifying the versions of FOSS components likely affected by newly disclosed vulnerabilities: a novel method that scans across the entire repository of a FOSS component in a matter of minutes. We show that our screening test scales to large open source projects. Finally, for facilitating the global security maintenance of a large portfolio of FOSS components, we discuss various characteristics of FOSS components and their potential impact on the security maintenance effort, and empirically identify the key drivers.
Numerical Modelling of Mixing in a Microfluidic Droplet Using a Two-Phase Moving Frame of Reference Approach

Droplets generated in microfluidic channels are effective self-contained micromixers and micro-reactors for use in a multiplicity of chemical synthesis and bioanalytical applications. Droplet microfluidic systems have the ability to generate multitudes of droplets with well-defined reagent volumes and narrow size distributions, providing a means for the replication of mixing within each droplet and thus the scaling of processes. Numerical modelling using computational fluid dynamics (CFD) is a useful technique for analysing and understanding the internal mixing in microfluidic droplets. We present and demonstrate a CFD method for modelling and simulating mixing between two species within a droplet travelling in straight microchannel, using a two-phase moving frame of reference approach. Finite element and level set methods were utilised to solve the equations governing the coupled physics between two-phase flow and mass transport of the chemical species. This approach had not been previously demonstrated for the problem of mixing in droplet microfluidics and requires less computational resources compared to the conventional fixed frame of reference approach. The key conclusions of this work are: (1) a limitation of this method exists for flow conditions where the droplet mobility approaches unity, due to the moving wall boundary condition, which results in an untenable solution under those conditions; (2) the efficiency of the mixing declines as the length of the droplet or plug increases; (3) the initial orientation of the droplet influences the mixing and the transverse orientation provides better mixing performance than the axial orientation and; (4) the recirculation inside the droplet depends on the superficial velocity and the viscosity ratio.
An empirical study on the effect of individual factors on tacit knowledge-sharing in the ICT sector

The main focus of this study is to examine the direct relationship between individual factors and tacit knowledge-sharing.A total of 400 questionnaires were distributed to the technical staff of the ICT sector in Jordan.Out of 400, only 365 were usable for further analysis, representing a response rate of 92.75%. Hypotheses for direct effect were tested using multiple regression analyses.Factors such as individual attitude, organizational commitment, knowledge self-efficacy, were found positively related to tacit knowledge-sharing.
Oral health aspects in sporadic and familial primary hyperparathyroidism

Background Primary hyperparathyroidism (pHPT) is the third most common endocrinopathy, affecting 1-3% of postmenopausal women, with a total incidence of 21.6 cases per 100,000 people in the adult population. This study aimed to analyze the oral health and related aspects of individuals with pHPT. Material and Methods A cross-sectional observational study was carried out on 51 patients diagnosed with pHPT associated with multiple endocrine neoplasia type 1 (MEN-1) (G1) or sporadic pHPT (G2). The oral aspects investigated were periodontal parameters, salivary flow, presence of dental caries, number of restored or missing teeth, and presence of tori. The biochemical parameters were collected in periods close to the dental evaluation. Results In G1, 29 individuals (19 females) aged 40.24±13.06 years were included; in G2, 22 individuals (21 females) aged 64.09±10.01 years were included. Grade 2 mobility (p=0.031), mean probing depth (p<0.001), loss of clinical insertion level (p<0.001), gingival bleeding (p=0.009), and presence of palatine tori (p=0.007) were higher in G1. A higher mean of tooth loss (17.90±13.42; p=0.031), teeth with active and/or inactive caries (p<0.001), and visual change in enamel/enamel breakdown (p<0.001) were also observed in G1. Most patients were 50 years old or younger, with a higher prevalence of older individuals in G2 (p<0.001). G1 showed low socioeconomic status and G2 medium-high status (p<0.001). Conclusions Despite the greater number of younger individuals, higher tooth loss and periodontal changes were observed in G1 patients. Differences in the degree of severity of pHPTor socioeconomic status alone could not explain these findings. Key words:Oral health, Primary hyperparathyroidism, Multiple endocrine neoplasia type 1, osteopenia, osteoporosis.
Effects of capacitive and resistive electric transfer therapy on pain and lumbar muscle stiffness and activity in patients with chronic low back pain

[Purpose] In this study, we investigated the therapeutic effects of capacitive and resistive electric transfer therapy in patients with chronic low back pain. [Participants and Methods] The study included 24 patients with chronic low back pain (12 patients each in the intervention and sham groups). Pain intensity, superficial and deep lumbar multifidus stiffness and maximum forward trunk flexion and associated activation level of the iliocostalis (thoracic and lumbar component) and lumbar multifidus muscles were measured. [Results] Post-intervention pain intensity and muscle stiffness were significantly lower than pre-intervention measurements in the intervention group. However, no between-group difference was observed in the muscle activation level at the end-point of standing trunk flexion. [Conclusion] Our findings highlight a significant therapeutic benefit of capacitive and resistive electric transfer therapy in patients with chronic low back pain and muscle stiffness.