Miracle-dz/UniFAR-FTUs huggingface dataset:
Urine excretion of C3dg and sC5b-9 coincide with proteinuria and development of preeclampsia in pregnant women with type-1 diabetes

Objective: Pregnant women with type-1 diabetes have an increased risk of preeclampsia with kidney injury and cardiovascular complications. Urine excretion of plasmin and soluble membrane attack complex (sC5b-9) is elevated in severe preeclampsia. We hypothesized a coupling between these events and that active plasmin promotes intratubular complement activation and membrane deposition. Methods: Stored urine and plasma samples from pregnant women with type-1 diabetes (n = 88) collected at gestational weeks 12, 20, 28, 32, 36 and 38 were used. In the cohort, 14 women developed preeclampsia and were compared with 16 nonpreeclampsia controls. Results: Urine C3dg and sC5b-9-associated C9 neoantigen/creatinine ratios increased and were significantly higher in women who developed preeclampsia. Plasma concentrations did not change with gestation. Urine plasmin(ogen) correlated to urine C3dg (r = 0.51, P < 0.001) and C9 neoantigen (r = 0.68, P < 0.001); urine albumin correlated to C3dg (r = 0.44, P < 0.001) and C9 (r = 0.59, P < 0.001). Membrane-associated C3dg and C9 neoantigen was detected in urinary extracellular vesicles from patients but not controls at 36 weeks. Receiver operating characteristic curves showed that C3dg and C9 neoantigen were inferior to albumin as predictive biomarkers for preeclampsia. Conclusion: In preeclampsia, urinary excretion of activated complement relates significantly to albuminuria and to plasmin(ogen) but not to activation in plasma. Intratubular complement activation in preeclampsia is a postfiltration event tightly related to proteinuria/plasminogenuria and a possible mechanistic link to cellular damage and kidney injury.
Post-traumatic brain injury glioma: Characteristics, report of 2 cases report and literature review

Background: Traumatic brain injury (TBI) as a pathogenetic factor in glioma remains controversial, and currently there is still no clear mechanism behind post-TBI glioma. Thus, we provide two case reports of post-TBI glioma contributing power to this research, and we provide a summary of the mechanisms of post-TBI glioma through literature review. Methods: We report two cases of brain gliomas that developed in the scar of a previous brain trauma. Both patients were male and both had suffered prior traumatic brain injuries (time interval 10–20 years), and postoperative pathological findings reported glioblastoma and WHO grade III glioma, respectively. Results: These two cases further support the association of between traumatic brain injury and gliomas development. Conclusion: Although the epidemiological investigation between TBI and glioma is still controversial, there are still some important aspects here that can determine the possibility between TBI and gliomagenesis. Besides, we found that the reparative response of neural stem cells and the dysregulation of inflammatory cells are timportant theories of the mechanism of post-TBI glioma.
Clinical features and outcomes of male patients with lymphangioleiomyomatosis: A review

Background: Lymphangioleiomyomatosis (LAM) is a rare disease involving multiple systems, which is divided into sporadic LAM (S-LAM) and tuberous sclerosis complex-LAM, mostly affecting women who are in childbearing age stage. Data on male patients are limited and scattered. Therefore, it is necessary to conduct a systematic review to investigate the clinical features, diagnosis, treatment, and outcomes of LAM in male. Methods: We performed a literature review by searching for all the published reported cases of LAM in male during the past 35 years (April 1986–October 2021). Results: 36 male patients described in 26 references were included in this article. The median age of onset was 34 years (interquartile range: 1–79). The most common initial manifestations were cough, dyspnea, respite, and hemoptysis, with pulmonary complications such as pneumothorax and chylothorax. Five patients (13.9%) were asymptomatic at admission. Nearly half of the 36 male patients had thin-walled air-filled cysts that were visible throughout both lungs. Considering the abovementioned atypical clinical features, misdiagnosis was committed in 8 patients (22.2%). In addition, patients with tuberous sclerosis complex lymphangioleiomyomatosis often have no pulmonary manifestations at onset but present multiple extrapulmonary manifestations and have higher rates of renal angiomyolipomas than patients with S-LAM (P < 0.01). Eventually, 4 patients with S-LAM eventually died. Conclusion: Physicians should increase the awareness of LAM in male. Early monitoring of various systems should be recommended to ensure early management and active follow-up. Tuberous sclerosis complex patients should immediately be tracked for the onset of LAM disease to improve prognosis.
Some necessary and sufficient conditions for eigenstructure assignment

Abstract Some necessary and sufficient conditions for closed-loop eigenstructure assignment by output feedback in time-invariant linear multivariable control systems are presented. A simple condition on a square matrix necessary and sufficient for it to be the closed-loop plant matrix of a given system with some output feedback is the basis of the paper. Some known results on entire eigenstructure assignment are deduced from this. The concept of an inner inverse of a matrix is employed to obtain a condition concerning the assignment of an eigenstructure consisting of the eigenvalues and a mixture of left and right eigenvectors.
Sleep fragmentation during rapid eye movement sleep and hypertension in obstructive sleep apnea

Objective: Sleep fragmentation determined by repetitive arousals from sleep in obstructive sleep apnea (OSA) is associated with hypertension. We aimed to quantify the independent association of arousals during rapid eye movement (REM)/non-rapid eye movement (NREM) sleep with prevalent hypertension. Methods: We included adults with 4 h of total sleep time and at least 30 min of REM sleep obtained from overnight in-laboratory polysomnography. Logistic regression models were fitted to explore the association between arousals during REM/NREM sleep and prevalent hypertension. All models controlled for OSA metrics and arousals during NREM/REM sleep, either by statistical adjustment or by stratification. Results: The sample comprised of 11 643 patients, of which 10 055 were OSA patients. Fully adjusted models demonstrated significant dose-relationships between arousal index during REM sleep (AI-REM) and prevalent hypertension (P trend = 0.002). The higher relative odds of prevalent hypertension were most evident with AI-REM > 40 events/h. In OSA patients with arousal index during NREM sleep (AI-NREM) <15 events/h, every10-unit increase in the AI-REM was associated with 18% higher odds of hypertension (odds ratio, 1.18; 95% confidence interval, 1.11–1.27) in OSA. On the contrary, AI-NREM was not a significant predictor of hypertension in any of the models. Conclusions: Our findings indicate that arousals during REM sleep are associated with prevalent hypertension. This is clinically relevant because treatment of OSA is often limited to the first half of the sleep period leaving most of sleep fragmentation during REM sleep untreated.
Poynting Jets from Accretion Disks: Magnetohydrodynamic Simulations

The powerful narrow jets observed to emanate from many compact accreting objects may arise from the twisting of a magnetic field threading a differentially rotating accretion disk that acts to extract magnetically the angular momentum and energy from the disk. Two main regimes have been discussed, hydromagnetic outflows, which have a significant mass flux and which have the energy and angular momentum carried by both the matter and the electromagnetic field, and Poynting outflows, in which the mass flux is negligible and the energy and angular momentum are carried predominantly by the electromagnetic field. Recent simulation studies have focused almost exclusively on hydromagnetic outflows. Here we consider a Keplerian disk initially threaded by a dipole-like poloidal magnetic field. We present the first MHD simulation results establishing that a quasi-stationary collimated Poynting jet arises from the inner part of the disk while a steady uncollimated hydromagnetic outflow arises in the outer part of the disk.
The Role of IL-18 and Human Cytomegalovirus in Type 1 Diabetes Mellitus in Thi-Qar Province

P revious studies indicated that elevated serum levels of Interleukin - 18 (IL-18) and human cytomegalovirus (HCMV) antibodies have a fundamental role in the pathogenesis of Type I diabetic mellitus T1DM. Therefore, the aim of the current study was to investigate the possible overlap between human cytomegalovirus (HCMV) and Interleukin-18 (IL-18) with the pathogenesis of T1DM. The serum of (45) T1DM patients and (45) healthy controls were used to detect IL-18 levels with an ELISA Kit and detect HCMV with cobas c411 apparatus for detect IgM and IgG HCMV. The results showed that the levels of IL-18 and human CMV IgM, IgG were significantly higher in patients with type 1 diabetes compared to the control group (45.8773 ±12.196 and 0.52 ± 0.25, 63.52 ±13.0 pg/ml for patients respectively) versus (12.611 ±3.9 and 0.11 ±0.01, 0.261 ±0.68 pg/ml for healthy subjects, respectively); The values were at P value ≤ 0.05. The results of the data concluded that there was a significant increase of IL-18 and human CMV IgM, IgG in the serum of the patient group compared to the lower levels in the control group, indicating that these markers may be involved in the pathogenesis and development of T. These data concluded that there was a significant increase in serum IL-18 and HCMV Abs, compared to the lower levels in the control group, indicating that these markers may be involved in the pathogenesis and development of T1DM.
The construction of emotional competency test kits for preschoolers

Emotional competence is one of the essential abilities to be possessed by children. Children with good emotional competence will be able to understand their emotions toward themselves or others well. This competence will help children adjust to and interact well in their social environment. This study aims to develop an emotional competency test kit for preschoolers. The items on this test kit are based on the theory of emotional competence presented by Denham. This test kit consists of eight-story scenarios that trigger the appearance of emotions in the child. The validity test on this test tool used expert judgment on 17 people consisting of early childhood care and education practitioners, child psychologists, parents, and Master of Professional Psychology students in Education, with the results of the analysis using Aiken’s V. Aiken’s V analysis results, obtained a validity coefficient of 0.71-0.95. Meanwhile, the results of the analysis of the test kit trial of 96 subjects obtained a reliability coefficient of emotional competency test kits of 0.801. This study showed that this test kit has good validity and reliability and can be used to measure emotional competence in preschoolers.
Use of Wharton's jelly-derived mesenchymal stromal cells for the treatment of equine recurrent uveitis: a pilot study

: Equine recurrent uveitis (ERU) is a disease that affects 2 to 25 % of equines worldwide, 56% of which go blind; therefore, it is considered the most common cause of blindness in horses. ERU is a spontaneous immune-mediated condition characterized by recurrent intraocular inflammatory events. Currently, there is no treatment for horses with this disease. Mesenchymal stromal cells (MSCs) derived from various tissues, such as Wharton's jelly (WJ)
Gender, work orientations and job satisfaction

This article studies the gender gap in job satisfaction and argues that the observed gender difference is a consequence of the heterogeneity in work orientations between men and women. Using data from the 2006 Skills Survey, the analysis yields three major findings. The first shows that women, either in full-time or part-time employment, report significantly higher levels of job satisfaction than men. Secondly, work orientations are closely associated with one’s job satisfaction and their relationships vary significantly across men, women full-time and part-time workers. Finally, and most importantly, the observed gender satisfaction differential is eliminated once work orientations are taken into consideration.
Coupled High-Order Shear Layerwise Analysis of Adaptive Sandwich Piezoelectric Composite Beams

A high-order discrete layer theoretical framework and a finite element are presented for predicting the electrostatic response of multifunctional beams with piezoelectric layers. A new layerwise coupled piezoelectric laminate theory is developed, in which quadratic and cubic fields are added to the in-plane displacement and electric potential approximation in each discrete layer. Interlaminar shear stress continuity is imposed through the thickness. Stiffness, piezoelectric, and permittivity matrices are formulated from ply to structural level. A finite element method and a beam element are further developed and used to predict the electrostatic response of piezocomposite beams. Numerical results and comparisons with linear layerwise beam finite element predictions illustrate the accuracy and capability of the developed mechanics to capture the local electric and shear stress response of smart piezoelectric composite beams efficiently and accurately, including beams of high thickness, beams with sandwiched foam cores, and/or beams with compliant shear layers.
Spectral Similarity of Fast-expanding Scattering-dominated Envelopes

We discuss recent numerical and analytical results that show that different sets of input parameters for supernova/nova model atmospheres yield synthetic spectra that are indistinguishable from one another. The underlying physical reason for this phenomenon is that the atmospheres are Thomson scattering-dominated, and have a gray scattering coefficient. Implications for distance measurements by means of the expanding photosphere method are briefly discussed.
The accuracy of parameter estimation from noisy data, with application to resonance peak estimation in distributed Brillouin sensing

Distributed Brillouin sensing of strain and temperature works by making spatially resolved measurements of the position of the measurand-dependent extremum of the resonance curve associated with the scattering process in the weakly nonlinear regime. Typically, measurements of backscattered Stokes intensity (the dependent variable) are made at a number of predetermined fixed frequencies covering the design measurand range of the apparatus and combined to yield an estimate of the position of the extremum. The measurand can then be found because its relationship to the position of the extremum is assumed known. We present analytical expressions relating the relative error in the extremum position to experimental errors in the dependent variable. This is done for two cases: (i) a simple non-parametric estimate of the mean based on moments and (ii) the case in which a least squares technique is used to fit a Lorentzian to the data. The question of statistical bias in the estimates is discussed and in the second case we go further and present for the first time a general method by which the probability density function (PDF) of errors in the fitted parameters can be obtained in closed form in terms of the PDFs of the errors in the noisy data.
Gamma-ray observations of the Galactic center - Removing the Galactic ridge contribution

Spectral measurements of the emission from the disk of the Galaxy from keV to GeV energies are combined. It is found that this emission has a similar spatial distribution at all energies: a longitude extent of about +/-40 deg and a latitude extent of about less than 5 deg. The emission over most of the energy range is dominated by cosmic-ray electrons and protons interacting with interstellar matter. The ridge spectrum is estimated to be near 100 keV using observations by HEAO A-4 from 1977 to 1979. To determine the emission from point sources in the region the diffuse component is substracted from Galactic center observations made by wide-field gamma-ray instruments over the past 20 years. The Galactic ridge accounts for between one-third and one-half of the observed flux for most of the measurements. Substracting the diffuse emission and GRS 1758-258 emission from the HEXAGONE observations on May 22 gives a spectrum that is dominated by lines from positron annihilation.
The environmental stability of field emission from single-walled carbon nanotubes

We demonstrate long-term field emission stability from single-walled carbon nanotubes. Unballasted nanotubes operate without degradation for over 350 h at 10−9 Torr. Nanotubes are shown to be significantly less sensitive to operating environments than metallic emitters. In 10−7 Torr of H2O, we demonstrate 100 h of continuous bias field emission with no current degradation. Protrusion growth and current runaway, typical problems for unballasted metal emitters, are not observed with nanotubes. Single-walled nanotubes do show susceptibility to damage by oxidation. We suggest that the exceptional environmental stability of carbon nanotubes is due to a combination of geometry, strong carbon bonding, and the lack of protrusion growth.
Treatment effect of job‐training programmes on unemployment duration in Slovakia

There is a large literature evaluating job‐training programmes. In this paper, we evaluate three such job‐training programmes that are used in Slovakia. Individuals participating in a job‐training programme during their unemployment spell are usually not a random subsample of the population. To determine the treatment effect of a job‐training programme on unemployment duration, one has to correct for this selection effect. Therefore, we use a multivariate mixed proportional hazard‐type model to describe the hazard of getting a job simultaneously with the hazard of entering a programme. We allow for a heterogeneous treatment effect and for the treatment effect to vary over time. Furthermore, we add the monthly unemployment rate as a time‐varying explanatory variable. The estimation results show that two of the three programmes shorten the unemployment duration quite substantially.
Spectral analysis of echoes for backscattering coefficient measurement

This paper describes spectral analyses of echoes scattered by a random medium and a plane reflector by using mathematical expressions of echoes which have been proposed by us before [M. Ueda and H. Ichikawa, J. Acoust. Soc. Am. 70, 1768–1775 (1981): 75, 1012 (1984)]. It becomes possible to express the spectrum of echoes scattered by the random medium in terms of a backscattering coefficient of the random medium and a velocity potential of an ultrasonic transducer. The expressions hold for any sound field if a correlation length of the random medium is much smaller than a beamwidth and a radius of the transducer. Then the spectrum of the echo scattered by the plane reflector is expressed in terms of a directivity of the transducer. By using a ratio of the two spectrums an expression which gives the backscattering coefficient of the random medium is formulated. It works in a farfield of a flat circular transducer and at a focal plane of a concave one. It is shown that our formula contains those cases which have been proposed so far as the extreme cases of the conditions. Finally, the backscattering coefficients of sponges are measured with several transducers. The results show that our formula gives the coefficients regardless of the transducer geometry.
Relationship between surface dipole, work function and charge transfer: Some exceptions to an established rule

Local-density-functional calculations are used to study the change of work functions induced by a layer of adsorbates. We investigated and compared the work function of a monolayer of Mo, Ag, Au, Fe, Co, Ni, Nb, Li, N, and O on W(100), W(110), W(211), and W(111) surfaces. While many systems obey the commonly accepted rule that electronegative adsorbates increase the work function of the surface, we find some exceptions. For example, overlayers of Fe, Co, and Ni increase the work function of W(100), W(211), and W(111), but decrease the work function of the W(110) surface, although the charge transfer is the same in all orientations. We found that even a layer of oxygen can decrease the work function of W(100), although there are always electrons transferred from the W substrate to the oxygen adsorbates. In order to understand these results, we established the relationship between surface dipole density and work function within the framework of local-density formalism. It turns out that subtle details of the charge transfer can determine the sign and magnitude of surface dipole change, leading to a strong dependence on the orientation of the substrate, with the consequence that the work-function changes are not always governed by the sign and quantity of adsorbate induced charge transfer.
First-principles calculation of the physical properties of GaAs1-xBix alloys

The structural, electronic and optical properties of GaAs1-xBix alloy are investigated using the density functional theory based on the full potential linearized augmented plane wave method as implemented in the Wien2k package. The exchange correlation potential is treated by generalized gradient approximation. We have studied the effect of Bi composition on equilibrium volume, energy band gap, electron and hole effective masses and dielectric function. For the electron and hole effective masses and the dielectric function variations versus bismuth composition, our results represent an attempt to investigate their qualitative trends.
Chaoticity on path space for a queueing network with selection of the shortest queue among several

We consider a network with N infinite-buffer queues with service rates λ, and global task arrival rate Nν. Each task is allocated L queues among N with uniform probability and joins the least loaded one, ties being resolved uniformly. We prove Q-chaoticity on path space for chaotic initial conditions and in equilibrium: any fixed finite subnetwork behaves in the limit N goes to infinity as an i.i. d. system of queues of law Q. The law Q is characterized as the unique solution for a non-linear martingale problem; if the initial conditions are q-chaotic, then Q 0 = q, and in equilibrium Q 0 = q ρ is the globally attractive stable point of the Kolmogorov equation corresponding to the martingale problem. This result is equivalent to a law of large numbers on path space with limit Q, and implies a functional law of large numbers with limit (Q t ) t≥0. The significant improvement in buffer utilization, due to the resource pooling coming from the choices, is precisely quantified at the limit.
Cross-correlation and system performance of modified prime codes for all-optical CDMA applications

Prime codes are a family of optical address codes that are suitable for optical fibre code-division multiple access (CDMA) systems using all-optical processing. However, the code weight w of a prime code is always fixed to the maximum number of users N. This means that, once N becomes large (e.g. in a system with many users), the resulting cost and optical power losses of all-optical CDMA encoder/decoder can be high. In turn, this may prevent the use of integrated optics from implementing such encoders and decoders. To effectively solve these problems, we present the modified prime (MPR) codes for all-optical CDMA systems. It is shown that MPR codes can maintain the fixed w for a given bit error rate (e.g. 10-9) but for any N. We also prove that MPR codes preserve the same cross-correlation constraint as original prime codes. Moreover, the proposed code-design procedure can be extended to construct special MPR codes, such as variable-length MPR codes and nonconstant-weight MPR codes.