Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of nitrogen fertilizer on the grain yield and quality of winter oats

Amounts of spring nitrogen (N) fertilizer (0–240 kg/ha), combined with three timing treatments (single, divided early or divided late), were tested at 14 sites in England and Wales between 1984 and 1988 to determine the optimum fertilizer N requirement for winter oats. The trials were superimposed on commercial crops of the cultivars Pennal (9 sites) or Peniarth (5 sites). Optimum amounts of N ranged from nil to 202 kg/ha (mean 119) and optimum yields varied between 5·8 and 9·9 t/ha (mean 7·3). Much (c. 60%) of the inter-site variation in N optimum was explained by differences in soil N supply, as indicated by N offtake in the grain at nil applied N. Mean yield differences between single and early (+0·08 t/ha) or late (−0·04 t/ha) divided dressings were slight, although significant (P<0·05) but inconsistent yield effects were obtained from early N at two sites and late N at three sites. Lodging occurred at 11 of the 12 sites where lodging scores were recorded and always increased significantly (P<0·05) with applied N. The amount of crop lodging at N optimum was, on an area basis, <50% at nine of the sites. The overall extent of site lodging was also influenced by soil N fertility and hence inversely related to N optimum. However, multiple regression, using site lodging as well as soil N supply, only accounted for slightly more (65%) of the variation in N optimum, which suggests that lodging was not a major limiting factor. Lodging was unexpectedly less from early N (mean 43%), but more from late N (53%) divided dressings, compared with a single N dressing (49%). Early N reduced lodging significantly (P<0·05) at four sites, although the actual reduction was only large at one site where early N also increased yield significantly (+0·57 t/ha). Grain N concentrations increased significantly (P<0·05) with applied N, on average by 0·12% per 40 kg/ha N increment. Timing effects on grain N concentration were very small, with mean values of 1·94, 1·91 and 1·96%N respectively from single, early and late divided dressings. Apparent recovery in grain of fertilizer N at the optimum amount ranged from 13 to 57% (mean 37), with better N recovery at the more yield-responsive sites. Changes in mean grain weight due to the amount and timing of fertilizer N were small, with an average reduction of 0·6 mg/grain per 40 kg/ha N applied. The adverse effects of N fertilizer on grain quality were slight and unlikely to have commercial significance. The agronomic implications of these results on the N fertilization of winter oats are discussed.
Preclinical Assessment of Immunocal® as a Preventative Treatment for Traumatic Brain Injury (TBI) in a Mouse Model of Closed Head Injury

Over the past three decades, traumatic brain injury (TBI) has been considered a "silent epidemic" and recognized as an emergent public health problem by the Centers for Disease Control and Prevention (CDC). TBI is defined as a bump, blow, or jolt to the head that disrupts the normal function of the brain. Due to the debilitating effects and prevalence of TBI, novel preventative treatment regimens are highly desirable in at risk populations. According to the CDC groups disproportionately affected by TBI include athletes, people aged 75+, and service men and women, among others. Here, we investigated a unique whey protein supplement, Immunocal®, to determine its ability to boost resilience of neurons prior to injury. It has been previously described that Immunocal ® functions specifically by increasing levels of the essential antioxidant glutathione (GSH). We hypothesize that boosting brain levels of GSH will help ameliorate cognitive, physical, and histopathological indices of brain injury post TBI in a mouse model of closed head impact injury. We found that twice daily oral supplementation with 3.30% Immunocal® for 28-35 days prior to impact significantly improved animal motor coordination and to a lesser extent, cognitive performance. Histopathological results also demonstrated a significant effect on corpus callosum width (axonal myelination) and a decreased presence of degenerating neurons in Immunocal®treated animals compared to untreated TBI animals. However, no effect was seen in iii measured clinical effects, or primary injury using MRI analysis. Finally, Immunocal® treatment prevented an ~30% reduction in the brain GSH/GSSG ratio observed in untreated TBI mice. These cumulative data suggest that Immunocal®, while unable to attenuate damage done by the primary injury, was helpful in alleviating secondary injury mechanisms in this TBI mouse model. In the future, this compound could hold promise as a preventative agent for in TBI in certain high risk populations.
Molybdenum-99 for Medical Imaging

The decay product of the medical isotope molybdenum-99 (Mo-99), technetium-99m (Tc-99m), and associated medical isotopes iodine-131 (I-131) and xenon-133 (Xe-133) are used worldwide for medical diagnostic imaging or therapy. The United States consumes about half of the world's supply of Mo-99, but there has been no domestic (i.e., U.S.-based) production of this isotope since the late 1980s. The United States imports Mo-99 for domestic use from Australia, Canada, Europe, and South Africa.Mo-99 and Tc-99m cannot be stockpiled for use because of their short half-lives. Consequently, they must be routinely produced and delivered to medical imaging centers. Almost all Mo-99 for medical use is produced by irradiating highly enriched uranium (HEU) targets in research reactors, several of which are over 50 years old and are approaching the end of their operating lives. Unanticipated and extended shutdowns of some of these old reactors have resulted in severe Mo-99 supply shortages in the United States and other countries. Some of these shortages have disrupted the delivery of medical care. Molybdenum-99 for Medical Imaging examines the production and utilization of Mo-99 and associated medical isotopes, and provides recommendations for medical use.
A Comparative Study of Short-Term Wind Speed Forecasting Models

The increasing trend to integrate intermittent wind generation in restructured power systems introduces several operational issues including reserve management and market performance. Therefore, Very Short-Term Forecasting (VSTF) of wind speeds is highly emphasized to address these issues by accurate prediction of Wind Farms’ (WFs) power outputs. State-of-the-art of VSTF typically provides a trade-off between machine learning and time series techniques. This paper provides an exhaustive study of statistical and machine learning VSTF models i.e. Linear Regression (LR), Autoregressive Integrated Moving Average (ARIMA) k -Nearest Neighbors ( k -NN) and Artificial Neural Network (ANN). The performance of these models is evaluated by Root Mean Square Error (RMSE) and Mean Absolute Error (MAE). The study is carried out on the dataset of WF located at Jaisalmer, Rajasthan, India. The results obtained concludes that ANN outperforms for VSTF of wind speed because of its ability to form complex non-linear systems for forecasting based on simple wind speed data. The ANN forecast accuracy is followed by LR, ARIMA and k -NN models.
The Transient Collaborative Network Approach: Theoretical and Practical Considerations

This conceptual article analyzes and connects theory to the practice of a novel inter-organizational form we call the transient collaboration network or TCN approach. Field observations in China suggest that emerging entrepreneurs enter into collaborations with supply chain partners under very different mindsets regarding interorganizational relationships, trust, collaboration and long-term expectations from traditional supply network practices. Briefly, these organizations cannot themselves build all resources needed for competitive advantages in volatile business environments. These entrepreneurs develop the TCN approach to allow their organizations to achieve full potential to locate and access the right resources at the right time through trusted collaborations in these dynamic or turbulent business environments. This paper analyzes principles that govern TCN interactions through the lens of Structural Contingency Theory, as extended to the inter-organizational level. Propositions explain how relations between structures and contingencies affect inter-organizational collaborative performances, and suggest how the TCN approach may be applicable to supply chain networks in general.
Maternal irisin level in last trimester isolated intrauterine growth-restriction

Abstract Purpose Intrauterine Growth Restriction (IUGR) is the inability of the fetus to achieve the biologically accessible growth potential. Irisin is a recently discovered adipomyokine with a crucial role in energy metabolism. Our current study aimed to investigate the relationship between the isolated IUGR in the third trimester and maternal serum irisin level. Materials and methods This prospective case-control study included total 137 pregnant women who were between the 24th and 39th gestational weeks and who applied to the University of Health Sciences, Ankara Zekai Tahir Burak Women's Health Training and Research Center, between 2016 October-2017 May. The Study Group consisted of 68 pregnant women who were diagnosed with Isolated IUGR with Estimated Fetal Weight (EFW) <10th percentile. The Control Group consisted of 69 low-risk uncomplicated pregnant women, matched with the Study Group in terms of gestational week, and with EFW between 10th and 90th percentiles. Demographic data, clinical findings, fetal Doppler parameters, and obstetric-neonatal outcomes were evaluated. Maternal serum irisin levels were measured by ELISA (Enzyme-Linked Immunosorbent Assay) Method and compared between the groups. Results Maternal serum irisin level was found to be significantly lower in IUGR Group as compared to the Control (3.83 ng/ml vs. 4.78 ng/ml, p < .001, respectively). There was a positive correlation between maternal serum irisin level and duration of pregnancy, the weight gain during pregnancy, birth weight, fetal abdominal circumference measurement and cerebroplacental ratio (r = 0.18, p = .03; r = 0.17, p = .04; r = 0.37, p < .001; r = 0.35, p < .001; r = 0.27, p = .001, respectively). Binary Logistic Regression Analysis showed that maternal serum irisin level is an independent estimator of IUGR [OR %95 CI: 8.33 (3.22 − 25.01)]. AUC (Area Under the Curve) analysis of maternal irisin for IUGR estimation was 0.75 (p < .001, 95% CI = 0.67 − 0.82). The optimal cutoff value was below 3.86 ng/ml for maternal irisin level with a sensitivity of 54.41% and a specificity of 88.41%, positive predictive value of 82.22% and negative predictive value of 66.30%. Conclusion Low level of maternal serum irisin in pregnancies with isolated IUGR was consistent with the role of irisin in metabolic pathways and with the increased risk of metabolic diseases in the future life of IUGR fetuses and their mothers.
Aortic stenosis in patients with kidney failure: Is there an advantage for a PD-first policy?

Aortic stenosis (AS) is the most common valvular disease. It is twice as prevalent in patients with kidney failure as compared to the general population. In addition, AS progresses at a faster rate and is associated with a higher risk of death and poorer quality of life in patients on dialysis. Chronic kidney disease–mineral and bone disorder (CKD-MBD), inflammation, and hemodynamic disturbances contribute to the pathophysiology and progression of AS. Whether the type of dialysis modality, that is, hemodialysis (HD) versus peritoneal dialysis (PD), has a differential impact on the development and progression of AS in patients with kidney failure remains debated. Recent data indicate that the prevalence of valvular calcifications might be lower and the development of AS delayed in PD patients, as compared to those treated with HD. This could be accounted for by several mechanisms including reduced valvular shear stress, better preservation of residual kidney function (with better removal of protein-bound uremic toxins and CKD-MBD profile), and lower levels of systemic inflammation. Given the high morbidity and mortality rates related to interventional procedures in the population with kidney failure, surgical and transcatheter aortic valve replacement should be considered in selected patients with severe AS. Strategies slowing down the progression of aortic valve remodeling should remain the cornerstone in the management of individuals with kidney failure and mild to moderate AS. This review explores the potential benefits of PD in patients with kidney failure and AS and provides some clues to help clinicians in the decision-making process when options for kidney replacement therapy are considered in patients with AS.
Community care staff attitudes towards delivering a falls prevention exercise intervention to community care clients.

Millions of older people world-wide receive community care services in their home to assist them to live independently. These services often include personal care, domestic assistance and social support which are delivered by non-university trained staff, and are frequently long term. Older people receiving community care services fall 50% more often than individuals of similar age not receiving services. Yet, few ongoing community care services include exercise programs to reduce falls in this population. We conducted an earlier study to examine the feasibility of community care staff delivering a falls prevention program. A critical finding was that while some of the assessment and support staff responsible for service delivery delivered the falls prevention exercise program to one or two clients, others delivered to none. Therefore, the aim of this qualitative sub-study was to understand reasons for this variation. Semi-structured interviews were conducted with 25 participating support staff and assessors from 10 community care organisations. Staff who had successfully delivered the intervention to their clients perceived themselves as capable and that it would benefit their clients. Older clients who were positive, motivated and wanted to improve were perceived to be more likely to participate. Staff who had worked at their organisation for at least 5 years were also more likely to deliver the program compared to those that had only worked up to 2 years. Staff that did not deliver the intervention to anyone were more risk averse, did not feel confident enough to deliver the program and perceived their clients as not suitable due to age and frailty. Experienced staff who are confident and have positive ageing attitudes are most likely to deliver falls prevention programs in a home care organisation.
The seed-specific heat shock factor A9 regulates the depth of dormancy in Medicago truncatula seeds via ABA signaling.

During the later stages of seed maturation, two key adaptive traits are acquired that contribute to seed lifespan and dispersal, longevity and dormancy. The seed-specific heat shock transcription factor A9 is an important hub gene in the transcriptional network of late seed maturation. Here we demonstrate that HSFA9 plays a role in thermotolerance rather than in ex situ seed conservation. Storage of hsfa9 seeds of Medicago truncatula and Arabidopsis had comparable lifespan at moderate storage relative humidity (RH), whereas at high RH, hsfa9 seeds lost their viability much faster than wild type seeds. Furthermore, we show that in M. truncatula, Mthsfa9 seeds acquired more dormancy during late maturation than wild type. Transient expression of MtHSFA9 in hairy roots and transcriptome analysis of Mthsfa9 Tnt1 insertion mutants identified a deregulation of genes involved in ABA biosynthesis, catabolism and signalling. Consistent with these results, Mthsfa9 seeds exhibited increased ABA levels and higher sensitivity to ABA. These data suggest that in legumes, HSFA9 acts as a negative regulator of the depth of seed dormancy during seed development via the modulation of hormonal balance. This article is protected by copyright. All rights reserved.
A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults

Abstract Background A previous RTS,S/AS01B vaccine challenge trial demonstrated that a 3-dose (0-1-7–month) regimen with a fractional third dose can produce high vaccine efficacy (VE) in adults challenged 3 weeks after vaccination. This study explored the VE of different delayed fractional dose regimens of adult and pediatric RTS,S/AS01 formulations. Methods A total of 130 participants were randomized into 5 groups. Four groups received 3 doses of RTS,S/AS01B or RTS,S/AS01E on a 0-1-7–month schedule, with the final 1 or 2 doses being fractional (one-fifth dose volume). One group received 1 full (month 0) and 1 fractional (month 7) dose of RTS,S/AS01E. Immunized and unvaccinated control participants underwent Plasmodium falciparum–infected mosquito challenge (controlled human malaria infection) 3 months after immunization, a timing chosen to potentially discriminate VEs between groups. Results The VE of 3-dose formulations ranged from 55% (95% confidence interval, 27%–72%) to 76% (48%–89%). Groups administered equivalent formulations of RTS,S/AS01E and RTS,S/AS01B demonstrated comparable VE. The 2-dose group demonstrated lower VE (29% [95% confidence interval, 6%–46%]). All regimens were well tolerated and immunogenic, with trends toward higher anti-circumsporozoite antibody titers in participants protected against infection. Conclusions RTS,S/AS01E can provide VE comparable to an equivalent RTS,S/AS01B regimen in adults, suggesting a universal formulation may be considered. Results also suggest that the 2-dose regimen is inferior to the 3-dose regimens evaluated. Clinical Trial Registration NCT03162614
The development of suppletive and affixal tense and agreement morphemes in the L3 English of Basque-Spanish bilinguals

This article examines the third language (L3) developing morphology of 78 Basque—Spanish bilinguals following a Content and Language Integrated Learning (CLIL) program and a mainstream English as a foreign language (non-CLIL) program. The analysis of cross-sectional and longitudinal oral data shows that (1) the omission of inflection in the L3 English interlanguage of these groups of learners is due to problems with the realization of surface morphology, (2) there is a dissociation in frequency of suppliance between suppletive inflection (copula and auxiliary be) and affixal inflection (the third person morpheme -s and the past tense morpheme -ed) already attested in L2 data, and (3) no significant differences were found between the two groups tested as far as the development of suppletive and affixal tense and agreement morphemes. The overall findings seem to support full-UG explanations for the variable use of morphology in the acquisition of non-native systems.
Distinct Developmental Patterns of Expression of Rat α1, α5, γ2S, andα12Lγ‐Aminobutyric AcidA Receptor Subunit mRNAs In Vivo and In Vitro

We have quantitated the α1, α5, γ2S, and γ2Lγ‐aminobutyric acidA (GABAA) receptor subunit mRNAs in the maturing cerebellum in vivo and in cerebellar granule neurons differentiating in vitro. Absolute amounts of mRNA were measured by reverse transcription and competitive polymerase chain reaction (PCR) analysis with appropriate internal standards. The α1 and γ2L mRNA content increased continuously during postnatal cerebellar maturation and their changes with time matched very closely those of the cerebellar granule cells differentiating in vitro. The γ2S subunit mRNA showed a relatively constant pattern of expression both in vivo and in vitro, with comparable absolute concentrations in both developmental paradigms. The α5 mRNA was initially high in vivo and decreased (eightfold) to adult levels as postnatal cerebellar development progressed. In vitro the amount of α5 GABAA receptor subunit mRNA was higher than in vivo at 3 days, increased by more than twofold by 8 days, and declined to approximately the initial values at 23 and 28 days in vitro. Collectively, the results indicate that the α1, α5, γ2S, and γ2L GABAA receptor subunit mRNAs are regulated differentially in a temporal manner during in vivo and in vitro maturation. Moreover, a comparison of the ontogenetic profiles of the γ2S and γ2L mRNAs indicates that alternative splicing of the γ2 primary RNA transcript is regulated developmentally during postnatal maturation of the rat cerebellum.
How Do Older Adults Recruited Using MTurk Differ From Those in a National Probability Sample?

A growing number of studies within the field of gerontology have included samples recruited from Amazon’s Mechanical Turk (MTurk), an online crowdsourcing portal. While some research has examined how younger adult participants recruited through other means may differ from those recruited using MTurk, little work has addressed this question with older adults specifically. In the present study, we examined how older adults recruited via MTurk might differ from those recruited via a national probability sample, the Health and Retirement Study (HRS), on a battery of outcomes related to health and cognition. Using a Latin-square design, we examined the relationship between recruitment time, remuneration amount, and measures of cognitive functioning. We found substantial differences between our MTurk sample and the participants within the HRS, most notably within measures of verbal fluency and analogical reasoning. Additionally, remuneration amount was related to differences in time to complete recruitment, particularly at the lowest remuneration level, where recruitment completion required between 138 and 485 additional hours. While the general consensus has been that MTurk samples are a reasonable proxy for the larger population, this work suggests that researchers should be wary of overgeneralizing research conducted with older adults recruited through this portal.
Healthy lifestyle and cancer risk among Chinese population in the Dongfeng-Tongji cohort

Abstract Background Studies on the association between healthy lifestyle and cancer risk are limited among the old Chinese population. Methods The healthy lifestyle score was derived from smoking, drinking, diet, body mass index and physical activity among 23734 retired employees from the Dongfeng-Tongji Cohort. Cox proportional hazards regression was used to calculate the hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs). The rate advancement periods (RAPs) and the population attributable risk percentage (PAR%) were estimated to indicate the benefits of removing risk lifestyle factors. Results During a median follow-up of 8.16 years, 2023 cancer cases were identified. Compared with 0–2 points of the healthy lifestyle score, the HRs were 0.87 (95% CI: 0.76, 0.99), 0.83 (95% CI: 0.73, 0.94), and 0.74 (95% CI: 0.64, 0.86) for 3, 4, and 5 points, respectively, with the corresponding RAPs of −4.40 (95% CI: −8.39, −0.41), −5.84 (95% CI: −9.77, −1.90), and −9.14 (95% CI: −14.03, −4.25), respectively. Approximately 15% of incident cancer cases among total population and 22% among men would be prevented by following all 5 healthy lifestyle factors. Conclusions The current study suggests that healthy lifestyle could reduce cancer risk in the retired Chinese population, especially in males. Key messages Healthy lifestyle derived by smoking, drinking, diet, body mass index and physical activity presented a strong protective effect on cancer risk among the retired Chinese population, especially in males. We employed the rate advancement periods and the population attributable risk percentage to indicate the benefits of adopting healthy lifestyle and we found that following all 5 healthy lifestyle factors could delay the risk of developing cancer by 9.14 years and prevent 15% of incident cancer cases.