Miracle-dz/UniFAR-FTUs huggingface dataset:
A 20–40 MHz low-power clock oscillator with open-loop frequency calibration and temperature compensation

In this paper, a 20–40 MHz low-power clock oscillator is presented to provide the frequency reference in data interface applications. The frequency source is referenced to a frequency-calibrated and temperature-compensated 2.5 GHz LC VCO that is implemented with a bondwire inductor. Class-C type VCO is adopted in order to improve the phase noise and reduce the current consumption. A full digital frequency calibration circuit is proposed to cover the wide output frequency range minimizing the frequency variation. External crystal oscillator (REF_CLK) is used only for the absolute frequency calibration at the initial programming stage and is not needed after the programming stage. On the other hand, temperature compensation is performed in an analogue way by controlling the varactor in the LC VCO. This chip is fabricated using 0.18-µm CMOS with the option of lateral PNP transistor. Lateral PNP transistors are used in the temperature compensation circuits. It can be implemented laterally in standard CMOS process. The power consumption is 4.8 mW from a 1.8 V supply. The accuracy of the frequency is ±58 ppm from −20°C to 80°C. The nominal phase noise at 1 MHz and period jitter is −122 dBc/Hz and 2 ps, respectively, when the output frequency is 25 MHz.
Desempenho de dois equipamentos na colheita semimecanizada da cultura da mandioca

The operational performance of two equipments for the cassava harvest was studied. A soil disaggregating implement and an up root implement were evaluated. The wheel slip, the losses, the mechanical damage caused in roots and the field capacity of the tractor-implement systems were analyzed. In each test, the whole roots and the roots with mechanical damages were separated and their mass were obtained. Tractor-up root system showed the best dynamic of cut and soil penetration, which was considered the smallest wheel slip. No root losses were observed for the two systems. Between implements there was not difference for mechanical damages caused in roots. The tractor-disaggregating implement system presented field capacity of 25% upper than tractor-up root system. However, as tractor-disaggregating implement system did not leave roots exposed and it did not have a frontal device of plant pruning, it was observed an increase of 32% on necessary time for cutting and roots separation. The tractor-up root system provided higher operational performance.
Sepsis in Children in Latin America

Abstract Pediatric sepsis is a worldwide public health issue because of its high mortality rate, which increases even more in low-income countries. In this article, we review the Latin American background, the burdens of pediatric sepsis in Latin America, and the Caribbean, as well as some strategies that could help improve the outcomes of sepsis in these regions from a public health view.
Soil organic matter and geochemical characteristics shape microbial community composition and structure across different land uses in an Australian wet tropical catchment

Soil characteristics vary across land uses, and soil microbial communities are likely to respond to such variations. However, such responses are not well understood. In this study, we examined how specific changes in soil organic matter (SOM) and geochemical characteristics influenced the bacterial and fungal community composition and structure across land uses. Soil samples were collected from grazing, sugarcane, forest and banana land uses in the Johnstone River catchment (wet tropics), northeastern Australia. High‐throughput sequencing of 16S rRNA gene and ITS amplicons were employed to characterise soil bacterial and fungal communities, respectively. Bacterial and fungal α‐diversity did not differ across land uses, whereas strong shifts in their community composition and structure were evident. Patterns in microbial community composition were strongly (p < 0.01) associated with changes in soil total organic carbon and nitrogen (TOC and TN), TOC:TN ratio, hot‐water extractable organic carbon (HWEOC) and soil geochemical characteristics (e.g., pH, Co, Mn, K, Mg and P contents). Distinct bacterial community composition was observed in forest soils, while fungal communities were similar in banana and forest soils compared with sugarcane and grazing. Overall, our results showed that SOM characteristics were the major driver on structuring soil microbial communities across land uses, while soil bacterial communities were more sensitive to variations in SOM and geochemical characteristics compared with fungi. Results from this study have implications for developing more targeted management practices across different land uses to improve soil health and ecosystem function in a wet tropical area.
Physiological Profiles of North Brazilian Mixed Martial Artists (MMA)

ABSTRACT Oliveira SN, Follmer B, Moraes MA, Santos JOL, Bezerra ES, Goncalves HJC, Rossato M. Physiological Profiles of North Brazilian Mixed Martial Artists (MMA). JEPonline 2015;18(1):56-61. The aim of this study was to characterize the anthropometric, physiological, and performance profile of a group of North Brazilian MMA athletes. Eighteen experienced male athletes (age 27.89 ± 5.92 yrs) were evaluated. The assessment consisted of: (a) body composition by the air displacement plethysmography method; (b) VO 2 max and VO 2 at ventilatory thresholds 1 (VT1) and 2 (VT2) by incremental treadmill test; (c) flexibility (FLEX) via the sit and reach test; and (d) handgrip strength (HGS), velocity (V max ), and maximum heart rate (HR max) during VT1 and VT2. The anthropometric results were body mass of 78.39 ± 6.95 kg and percent body fat of 14.97 ± 7.27%. The physiological assessments were represented by VO 2 max (44.22 ± 6.69 mlkg -1 min -1 ), VT1 (27.52 ± 5.78 mlkg -1 min -1
Why are Interest Rates on Bank Deposits So Low?

Using granular data of German banks for the 2003 to 2018 period, we analyze the determinants of bank rates on retail deposits. We find that a bank’s rate on sight deposits is especially low if the bank operates in rural districts, if it is not exposed to strong competition and if it provides much service. Regarding the rates on term deposits, we find that the bank’s cost situation plays a role: if the bank’s costs are high, its deposit rates are low. By transferring concepts from portfolio theory to the pass-through topic, we show that replicating portfolio approaches are often equivalent to regression approaches and that, under some assumptions, the classical regression approach corresponds to a replicating portfolio approach.
The Effect of Direct and Indirect EZH2 Inhibition in Rhabdomyosarcoma Cell Lines

Simple Summary Rhabdomyosarcoma is the most common soft tissue tumor in children. Its two major subtypes show epigenetic alterations that are associated with poor prognosis. Therefore, targeting these epigenetic alterations by pharmacological intervention could be a therapeutic approach. We investigated two different types of substances that interfere with the epigenetic process of histone methylation. We performed studies in two cell lines that carry characteristics of the major rhabdomyosarcoma subtypes. The aim of this study was to find out if the substances differ in their effect on tumor-related cellular functions and to find out if the tumor subtypes differ in their response to the substances. These findings may contribute to a better assessment of the feasibility of pharmacological intervention directed against histone methylation in subtypes of rhabdomyosarcoma. Abstract Enhancer of Zeste homolog 2 (EZH2) is involved in epigenetic regulation of gene transcription by catalyzing trimethylation of histone 3 at lysine 27. In rhabdomyosarcoma (RMS), increased EZH2 protein levels are associated with poor prognosis and increased metastatic potential, suggesting EZH2 as a therapeutic target. The inhibition of EZH2 can be achieved by direct inhibition which targets only the enzyme activity or by indirect inhibition which also affects activities of other methyltransferases and reduces EZH2 protein abundance. We assessed the direct inhibition of EZH2 by EPZ005687 and the indirect inhibition by 3-deazaneplanocin (DZNep) and adenosine dialdehyde (AdOx) in the embryonal RD and the alveolar RH30 RMS cell line. EPZ005687 was more effective in reducing the cell viability and colony formation, in promoting apoptosis induction, and in arresting cells in the G1 phase of the cell cycle than the indirect inhibitors. DZNep was more effective in decreasing spheroid viability and size in both cell lines than EPZ005687 and AdOx. Both types of inhibitors reduced cell migration of RH30 cells but not of RD cells. The results show that direct and indirect inhibition of EZH2 affect cellular functions differently. The alveolar cell line RH30 is more sensitive to epigenetic intervention than the embryonal cell line RD.
In search of healthcare system ideal types — Changeable classifications and dimensions

This article aims to classify the healthcare systems of 43 developed economies into different healthcare system types, and to examine whether the dimensions of health system characteristics produce coherent health system classification when the dimensions are observed separately. We group health systems into different types based on their institutional structures and performance using healthcare financing, healthcare provision and health outcomes as dimensions of the health system characteristics. Unlike previous classifications, we classify each dimension separately using hierarchical cluster analysis. In particular dimensions, our results resemble those found in previous classifications. However, no coherent clustering of healthcare systems was found across the three dimensions. The results show that healthcare system dimensions differ from each other and each of them form their unique system types. Separating the dimensions helps detecting connections between the healthcare system types and phenomena being studied. It is relevant to note the differences of health system dimensions while discussing healthcare system classifications.
Characterization of a Novel High Internal Phase Pickering Emulsions Stabilized by Soy Protein Self-Assembled Gel Particles

In this paper, a novel high-internal-phase Pickering emulsion (HIPPE) prepared by acid-induced self-assembly SPI gel (A/S-SPIG) was investigated. The steady-state shear test results showed that all HIPPEs were typical shear thinning emulsion, which could form stable emulsion (0.2–1.2% SPI concentration). The network structure of HIPPE stabilized by A/S-SPIG particles (0.2–1.2% SPI concentration) was continuously enhanced with increasing SPI concentration. The high concentration of SPI particles increased the crystallization temperature of the stabilized HIPPE. Meanwhile, at a concentration of 1.2%, HIPPE has the best cohesive property and stability against delamination due to weakened mobility. In conclusion, A/S-SPIG was proved excellent HIPPE stabilized particle.
Clearance of HR-HPV within one year after focused ultrasound or loop electrosurgical excision procedure in patients with HSIL under 30

Abstract Objective To compare the clearance rate of high-risk human papillomavirus (HR-HPV) in patients with a high-grade squamous intraepithelial lesion (HSIL) 12 months after focused ultrasound (FUS) or loop electrosurgical excision procedure (LEEP), and analyze the influencing factors. Methods A retrospective cohort was established in HSIL patients with HR-HPV infection treated with FUS or LEEP from 2015 to 2019. The cohort consisted of 321 patients under 30 years of age, of which 119 patients received FUS and 202 patients received LEEP. The Cox regression model was used to identify the influencing factors for HR-HPV clearance. Kaplan–Meier method was applied to estimate the efficacy of FUS and LEEP in HR-HPV clearance, and the log-rank test was used to compare the efficacy difference between FUS and LEEP. Results Multivariate Cox regression analysis showed that both FUS and LEEP were independent influencing factors for HR-HPV clearance. HR-HPV cleared faster in the FUS group than in the LEEP group [the median time to HR-HPV clearance: 6 months in the FUS group (95% CI: 5.492–6.508) and 6 months in the LEEP group (95% CI: 5.734–6.266), p = 0.021]. The HR-HPV clearance rates at 6 and 12 months were 54.6% and 94.1% respectively in the FUS group, and 50.5% and 79. 2%, respectively in the LEEP group (p = 0.001 at 6 months, p = 0.000 at 12 months). Conclusions For HPV-positive HSIL patients under 30, FUS had a better HR-HPV clearance effect than LEEP 1 year after treatment. FUS may be a viable modality for the treatment of young HSIL patients.
High-performance collector-up InGaP/GaAs heterojunction bipolar transistor with Schottky contact

The first fabrication and RF characterisation of an InGaP/GaAs single heterojunction bipolar transistor in collector-up topology with Schottky contact are reported. Boron implantation is employed to prevent current injection into the extrinsic base region. Realised devices exhibit F/sub MAX/=110 GHz and breakdown voltage BV/sub CE0/=16 V. The RF gain of these components appears to be less sensitive to HBT development than standard emitter-up HBTs.
Role of epigenetics in parturition and preterm birth

Preterm birth occurs worldwide and is associated with high morbidity, mortality, and economic cost. Although several risk factors associated with parturition and preterm birth have been identified, mechanisms underlying this syndrome remain unclear, thereby limiting the implementation of interventions for prevention and management. Known triggers of preterm birth include conditions related to inflammatory and immunological pathways, as well as genetics and maternal history. Importantly, epigenetics, which is the study of heritable phenotypic changes that occur without alterations in the DNA sequence, may play a role in linking social and environmental risk factors for preterm birth. Epigenetic approaches to the study of preterm birth, including analyses of the effects of microRNAs, long non‐coding RNAs, DNA methylation, and histone modification, have contributed to an improved understanding of the molecular bases of both term and preterm birth. Additionally, epigenetic modifications have been linked to factors already associated with preterm birth, including obesity and smoking. The prevention and management of preterm birth remains a challenge worldwide. Although epigenetic analysis provides valuable insights into the causes and risk factors associated with this syndrome, further studies are necessary to determine whether epigenetic approaches can be used routinely for the diagnosis, prevention, and management of preterm birth.
Does Environmental Regulation Promote Environmental Innovation? An Empirical Study of Cities in China

Promoting environmental innovation through environmental regulation is a key measure for cities to reduce environmental pressure; however, the role of environmental regulation in environmental innovation is controversial. This study used the number of environmental patent applications to measure urban environmental innovation and analyzed the role of urban environmental regulation on urban environmental innovation with the help of the spatial Durbin model (SDM). The results showed that: (1) From 2007 to 2017, the number of environmental patent applications in China has grown rapidly, and technologies related to buildings dominated the development of China’s environmental innovation. (2) Although the number of cities participating in environmental innovation was increasing, China’s environmental innovation activities were highly concentrated in a few cities (Beijing, Shenzhen, and Shanghai), showing significant spatial correlation and spatial agglomeration characteristics. (3) Urban environmental regulation had a positive U-shaped relationship with urban environmental innovation capability, which was consistent with what the Porter hypothesis advocates.
A system-wide health sciences faculty mentor training program is associated with improved effective mentoring and institutional climate

Abstract Introduction: Mentorship is critical for faculty success, satisfaction, and engagement. However, many faculty, particularly underrepresented racial/ethnic (UR) faculty, lack access to high-quality mentoring. In an effort to improve mentoring for all faculty, we developed and implemented a formally structured faculty mentor training program (FMTP) across UC San Diego Health Sciences, which included institutional support, mentorship training, and department/division mentorship programs. Methods: FMTP impact was evaluated using three primary outcome variables: mentoring quality, mentoring behaviors, and institutional climate. Participants’ self-assessed mentoring competencies were measured using validated instruments. Results: A total of 391 (23%) of Health Sciences faculty participated in FMTP. Participation rate was higher for women than men (30% versus 17%) and highest for UR faculty (39%). FMTP was implemented in 16 of 19 departments. Self-reported mentoring improved for FMTP participants with mentoring quality (p = 0.009) and meeting mentees’ expectations (p = 0.01) continuing to improve for up to 2 years after training. However, participants were unsure if they were meeting UR mentees’ expectations. FMTP participants were significantly more satisfied with mentoring quality (p < 0.001) compared to non-participants, with the greatest increase in satisfaction reported by UR faculty (38–61%). UR faculty reported improved overall morale (51–61%) and a perception that the environment was supportive for UR faculty (48–70%). Conclusion: The implementation of a system-wide formal structured FMTP was associated with improved faculty satisfaction, quality of mentoring, and institutional climate, especially for UR faculty.
Transferability of western MNCs human resource management practices: A case study

The purpose of this research is to understand the current prospect of Human Resources Management practices and its transferability in Bangladesh. This study was conducted in the US and UK MNCs operating in Bangladesh. In this study, in-depth interview and structure questionnaire methods have been used to collect data. The objectives of this study are to investigate insightful and classified information related to human resource management (HRM) practices and their transferability for both MNCs in Bangladesh. Study found that the transferability of MNC 's HRM in South Asia, Bangladesh has a very bright and promising potential. The study has shown that the adaptability rate is very high and the host country companies are practicing HRM with successful combination of both, their host country's policies and practices as well as the home countries '. The position of HRM is broad and now open to all so the possibility of the transferability of MNC 's HRM in Bangladesh is oblivious and is setting a vibrant remark in these days. The existing paper explores the employee cultural values of UK and US multinationals companies (MNCs) and their transformation of cultural adaptation on HRM practices in developing countries like Bangladesh.
Artificial Intelligence-Enabled DDoS Detection for Blockchain-Based Smart Transport Systems

A smart public transport system is expected to be an integral part of our human lives to improve our mobility and reduce the effect of our carbon footprint. The safety and ongoing maintenance of the smart public transport system from cyberattacks are vitally important. To provide more comprehensive protection against potential cyberattacks, we propose a novel approach that combines blockchain technology and a deep learning method that can better protect the smart public transport system. By the creation of signed and verified blockchain blocks and chaining of hashed blocks, the blockchain in our proposal can withstand unauthorized integrity attack that tries to forge sensitive transport maintenance data and transactions associated with it. A hybrid deep learning-based method, which combines autoencoder (AE) and multi-layer perceptron (MLP), in our proposal can effectively detect distributed denial of service (DDoS) attempts that can halt or block the urgent and critical exchange of transport maintenance data across the stakeholders. The experimental results of the hybrid deep learning evaluated on three different datasets (i.e., CICDDoS2019, CIC-IDS2017, and BoT-IoT) show that our deep learning model is effective to detect a wide range of DDoS attacks achieving more than 95% F1-score across all three datasets in average. The comparison of our approach with other similar methods confirms that our approach covers a more comprehensive range of security properties for the smart public transport system.
Associations between Fluctuating Shame, Self-Esteem, and Sexual Desire: Comparing Frequent Porn Users and a General Population Sample

In the present study, we explore the proposed cyclic models for problematic hypersexuality (PH) that involve shame, self-esteem, and sexual desire. These cyclic models are characterized by temporal associations but have not been investigated previously with intensive longitudinal designs. In this study, we collected up to 70 measurements per participant within a period of seven consecutive days, which allowed us to investigate associations between fluctuations of shame, self-esteem, and sexual desire. Participants were divided in four subgroups: (1) women (n = 87); (2) men (n = 46) from a general population convenience sample; (3) men watching porn >2 times per week, showing non-problematic hypersexuality (NH; n = 10); and (4) men watching porn >2 times per week, experiencing PH (n = 11). Multilevel analyses, including cross-level interactions, were used to investigate between-group differences in intraindividual processes. Results showed that prior increases in shame forecasted higher current sexual desire for men with PH, but not for the other groups, suggesting that men with PH use sexual desire to downregulate dysphoric feelings of shame. Differences between groups in associations between self-esteem and sexual desire were also found. Based on our results, we propose the Split Pleasure/Shame model, which represents emotion dysregulation in PH, and juxtapose this with the pleasurable experience of sex by non-PH groups. Further intensive longitudinal research is necessary to test this model and, more generally, to investigate the fluctuating nature of sexual desire.
Basic Need Satisfaction Intervention for Mainland Chinese International Students’ Adjustment to College

With an increasing number of students pursuing their tertiary studies overseas, ways to improve their adaptation into a new environment become of the utmost importance. By applying self-determination theory, the current research investigated the extent that a basic psychological need intervention can increase need-satisfying experiences and promote the adjustment of Mainland Chinese international students to college. In total, 55 participants were randomly assigned to an intervention or control condition. They completed questionnaires on basic need satisfaction and college adjustment before the start of the study, right after the completion of the intervention, and after a 5-week follow-up. Participants who received the intervention had significantly higher need satisfaction and adjustment to college than those in the control condition. The intervention effect was maintained after a 5-week delay. In addition, the results showed that the increases in psychological need satisfaction after the intervention predicted higher levels of students’ adjustment to college. Theoretical implications for the universality of basic need satisfaction to students’ well-being and practical implications for international education are discussed.