Miracle-dz/UniFAR-FTUs huggingface dataset:
Rates, perceptions and predictors of depression, anxiety and Post Traumatic Stress Disorder (PTSD)-like symptoms about Covid-19 in adolescents

Increasing evidence has shown that the Covid-19 outbreak, and subsequent school closures and exam cancellations that followed, has impacted adolescent mental health. The current cross-sectional study examined rates of depression, anxiety and Post Traumatic Stress Disorder (PTSD)-like symptoms about Covid-19 in adolescents and whether current or past mental health support, additional support in school, keyworker status, poorer household relationships since the outbreak of Covid-19 or reduced physical activity were associated with elevated levels of depression, anxiety or PTSD-like symptoms. Lastly, it examined perceived changes in mental health due to the Covid-19 pandemic, school closures and the cancellation of exams. A total of 899 adolescents (14–18 years) took part in the ’in isolation instead of in school’ (INISS) project. Findings indicated that older adolescents, females, those who currently or previously received mental health support or additional support in school and adolescents who reported poorer relationships at home since Covid-19 were more likely to meet clinical threshold levels for their mental health. Adolescents highlighted worsening of their mental health due to Covid-19 and school closures with mixed positive and negative impact of exam cancellations. Adolescents experiencing clinical threshold levels of depression and anxiety uniquely reported worsening of their mental health since the Covid-19 pandemic, school closures and exam cancellations. Understanding the rates, perceptions and factors associated with increases in depression, anxiety and PTSD-like symptoms in adolescents during the Covid-19 pandemic will inform national policy in supporting adolescent mental health and recovery from the Covid-19 pandemic.
PENGARUH PROFITABILITAS, LIKUIDITAS, DAN UKURAN PERUSAHAAN TERHADAP OPINI AUDIT GOING CONCERN Studi pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Tahun 2012-2015

Penelitian ini bertujuan untuk mengetahui: (1) Pengaruh Profitabilitas terhadap Opini Audit Going Concern, (2) Pengaruh Likuiditas terhadap terhadap Opini Audit Going Concern, (3) Pengaruh Ukuran Perusahaan terhadap terhadap Opini Audit Going Concern, (4) Pengaruh Profitabilitas, Likuiditas, dan Ukuran Perusahaan terhadap Opini Audit Going Concern pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia pada tahun 2012-2015 Jenis penelitian ini adalah penelitian kausal komparatif. Populasi dalam penelitian ini adalah perusahaan yang terdaftar di Bursa Efek Indonesia pada tahun 2012-2015. Teknik pengambilan sampel menggunakan teknik purposive sampling. Sampel berjumlah 30 perusahaan dari 144 perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia tahun 2012-2015, sehingga data penelitian yang dianalisis berjumlah 120. Teknik analisis data yang digunakan adalah statistik deskriptif dan regresi logistik. Berdasarkan hasil penelitian ini menunjukkan bahwa (1) Profitabilitas berpengaruh dan signifikan terhadap Opini Audit Going Concern, hal ini ditunjukkan dengan nilai koefisien regresi sebesar -8,188 dan nilai signifikansi lebih kecil dari 0,05 yaitu 0,014. (2) Likuiditas tidak berpengaruh dan signifikan terhadap Opini Audit Going Concern, hal ini ditunjukkan dengan nilai koefisien regresi sebesar -0,480 dan nilai signifikansi lebih besar dari 0,05 yaitu 0,157. (3) Ukuran Perusahaan berpengaruh dan signifikan terhadap Opini Audit Going Concern, hal ini ditunjukkan dengan nilai koefisien regresi sebesar -0,434 dan nilai koefisien lebih kecil dari 0,05 yaitu 0,019. (4) Profitabilitas, Likuiditas, dan Ukuran Perusahaan berpengaruh terhadap Opini Audit Going Concern.
To Lead, or to Follow? How Self-Uncertainty and the Dark Triad of Personality Influence Leadership Motivation

Under uncertainty, leaders who possess dark triad personality traits seem able to attain leadership positions. We draw on uncertainty-identity theory and dark triad research to explore the effect of self-uncertainty on leadership motivation. Uncertainty-identity theory predicts that people can reduce self-uncertainty by identifying with groups and following their leaders, which suggests that self-uncertainty reduces people’s own leadership motivation. However, individuals high in dark triad traits (Machiavellianism, narcissism, and psychopathy) have such a powerful drive for dominance over others that their leadership motivation may be unaffected by self-uncertainty. To test these predictions, we conducted four studies (Ns = 2,641, 421, 513, and 400). We found that self-uncertainty reduced leadership motivation for individuals low in the dark triad. In contrast, those high in the dark triad had an elevated leadership motivation that remained unaltered when they were self-uncertain. These effects were mediated by participants’ negative affect. We discuss the implications of these findings.
Family Caregivers’ Experiences of Caring for Advanced Cancer Patients

Background Advanced cancers qualify as severe stressors to family caregivers (FCGs), which can negatively impact caregivers’ psychological and physical well-being because of their association with high symptom burden, distress, and poor prognosis. Objective This review aims to synthesize FCGs’ experiences of caring for advanced cancer patients using a qualitative systematic review method. Methods A comprehensive search was conducted in 7 databases from inception until July 2020. Two reviewers independently screened and assessed each study using Joanna Briggs Institute instruments and subsequently undertook the meta-aggregation approach to synthesize findings. Results A total of 26 studies were included, refined to 37 findings, and integrated into 9 categories and 5 synthesized findings. When a loved one with advanced cancer faced deterioration near the end of their life, FCGs showed a tremendous sense of responsibility for care and concerted great efforts to alleviate their loved one’s suffering while lacking effective professional support. Cultural beliefs had a great impact on FCGs’ responsibility and role recognition. Ultimately, the caregiving helped FCGs achieve personal transcendence inherent in their unique experience. Conclusions Caring for advanced cancer patients is a unique, culture-specific experience marked by struggle. Effective professional support, including early palliative care, should be considered to improve the FCGs’ experience of caring for advanced cancer patients. Cultural beliefs should be considered to understand and develop appropriate strategies to support FCGs. Implications for Practice Healthcare providers need to ensure that individualized, multifaceted interventions considering FCGs’ needs are delivered at the optimal time with the appropriate approach.
Three decades of heart transplantation: experience and long-term outcome

Abstract Objectives. Heart transplantation (HTx) has become an established treatment option in patients with end-stage heart failure. The aim of this study was to report on long-term outcome over the past three decades. Design. Consecutive adult patients receiving first-time and isolated HTx from October 3, 1990, to November 2, 2020, at Rigshospitalet, Copenhagen, Denmark, were retrospectively evaluated. Data were obtained from the Scandinavian Transplant Registry and patient medical records. Recipients were grouped by time of transplantation (early era: 1990–1999; mid era: 2000–2009; recent era: 2010–2020). Results. A total of 384 recipients (77% men, median age 50 [IQR: 40–57]) were included. Median number of HTx procedures per year was 12 (10–14). Overall, 22% of patients were bridged to HTx with a mechanical circulatory support device. Median survival for the whole cohort was 13.8 years and improved numerically from the early era (12.6 years) to the mid era (14.9 years). Median survival conditional on survival to 1-year follow-up after HTx was 16.1 years. Survival probability by Kaplan–Meier method improved significantly from the mid to the recent era (log-rank p = .02). Conclusions. Heart transplantation remains an excellent treatment for selected patients with end-stage heart failure and long-term outcome has improved significantly over the past decades.
Association of Phosphate-Containing versus Phosphate-Free Solutions on Ventilator Days in Patients Requiring Continuous Kidney Replacement Therapy

Visual Abstract Background and objectives Hypophosphatemia is commonly observed in patients receiving continuous KRT. Patients who develop hypophosphatemia may be at risk of respiratory and neuromuscular dysfunction and therefore subject to prolongation of ventilator support. We evaluated the association of phosphate-containing versus phosphate-free continuous KRT solutions with ventilator dependence in critically ill patients receiving continuous KRT. Design, setting, participants, & measurements Our study was a single-center, retrospective, pre-post cohort study of adult patients receiving continuous KRT and mechanical ventilation during their intensive care unit stay. Zero-inflated negative binomial regression with and without propensity score matching was used to model our primary outcome: ventilator-free days at 28 days. Intensive care unit and hospital lengths of stay as well as hospital mortality were analyzed with a t test or a chi-squared test, as appropriate. Results We identified 992 eligible patients, of whom 649 (65%) received phosphate-containing solutions and 343 (35%) received phosphate-free solutions. In multivariable models, patients receiving phosphate-containing continuous KRT solutions had 12% (95% confidence interval, 0.17 to 0.47) more ventilator-free days at 28 days. Patients exposed to phosphate-containing versus phosphate-free solutions had 17% (95% confidence interval, −0.08 to −0.30) fewer days in the intensive care unit and 20% (95% confidence interval, − 0.12 to −0.32) fewer days in the hospital. Concordant results were observed for ventilator-free days at 28 days in the propensity score matched analysis. There was no difference in hospital mortality between the groups. Conclusions The use of phosphate-containing versus phosphate-free continuous KRT solutions was independently associated with fewer ventilator days and shorter stay in the intensive care unit.
Generation of Mature DENVs via Genetic Modification and Directed Evolution

Mature DENVs represent the dominant form in vivo and are the target for vaccine development. Here, we used multiple strategies, including protein engineering and natural and directed evolution to generate DENV1, -2, -3, and -4 variants that are highly mature without compromising replication efficiency compared to the parental strains. ABSTRACT Maturation of dengue viruses (DENVs) alters the structure, immunity, and infectivity of the virion and highly mature particles represent the dominant form in vivo. The production of highly mature virions principally relies on the structure and function of the viral premature membrane protein (prM) and its cleavage by the host protease furin. We redeveloped a reliable clonal cell line (VF1) which produces single-round mature DENVs without the need for DENV reverse genetics. More importantly, using protein engineering and directed evolution of the prM cleavage site, we engineered genetically stable mature DENVs in all serotypes independent of cell or host, usually with minimal impact on viral yield. Using these complementary strategies to regulate maturation, we demonstrate that the resulting mature DENVs are antigenically distinct from their isogenic partially mature forms. Given the clinical importance of mature DENVs in immunity, our study provides reliable strategies and reagents for the production of stable, high-titer mature DENVs for DENV antibody neutralization and vaccination immunity studies. Biologically, our data from directed evolution across host species reveals distinct maturation-dependent selective pressures between mammalian and insect cells, verifying the substrate preference between mammalian and insect furin, while hinting at an evolutionary equilibrium of DENV prM cleavage site between its host and vector in nature. IMPORTANCE Mature DENVs represent the dominant form in vivo and are the target for vaccine development. Here, we used multiple strategies, including protein engineering and natural and directed evolution to generate DENV1, -2, -3, and -4 variants that are highly mature without compromising replication efficiency compared to the parental strains. Given the clinical importance of mature DENVs in immunity, this work provides a roadmap for engineering highly mature DENV that could apply to future vaccine development. Our directed-evolution data also shed light on the divergent evolutionary relationship of DENVs between its host and vector.
How Many Nights Are Really Needed to Diagnose Obstructive Sleep Apnea?

would be this: In what percentage of cases could this variability lead physicians to change their therapeutic decision (e.g., the indication of CPAP or alternative treatments)? To make this calculation, the authors would need access to individual patients’ clinical data. We do not know howmany of the studied patients were treated with CPAP (or alternatives), but even without this information, the authors could make an estimate based on the indications for treatment specified in the different international guidelines (5). On the other hand, the authors could offer additional clinically relevant information by assessing theminimumnumber of consecutive sleep studies needed tominimize their variability and thus reduce costs. The authors observe that themore sleep tests that are performed, the more the AHI stabilizes, according to an analysis of the different areas under the receiver operating curve (ROC) curves at differentmoments in time. Thus, it can be seen that, although the variability was very high in the first days, it wasmuch lower after 1 week and evenmore so after 2 weeks, although the results obtained onDays 7 and 14 were very similar. The authors could calculate the relevant differences between the various areas under the ROC curves from clinical and statistical viewpoints. This information would be of enormous clinical relevance, as it would indicate theminimumnumber of days required for sleep tests to obtain an optimal balance between the least variability that would allow a minimumnumber of clinically acceptablemisclassifications (and, above all, a minimumnumber of relevant therapeutic changes) and lower costs, less time tomake an accurate diagnosis, and fewer resources. Therefore, we believe that it would be very interesting and enriching for the study, and for clinicians who care for patients with OSA, if the authors could contribute these suggested new analyses to their already excellent study.
Children’s and adults’ use of fictional discourse and semantic knowledge for prediction in language processing

Using real-time eye-movement measures, we asked how a fantastical discourse context competes with stored representations of real-world events to influence the moment-by-moment interpretation of a story by 7-year-old children and adults. Seven-year-olds were less effective at bypassing stored real-world knowledge during real-time interpretation than adults. Our results suggest that children privilege stored semantic knowledge over situation-specific information presented in a fictional story context. We suggest that 7-year-olds’ canonical semantic and conceptual relations are sufficiently strongly rooted in statistical patterns in language that have consolidated over time that they overwhelm new and unexpected information even when the latter is fantastical and highly salient.
Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer regulates the ROS–STAT3 pathway

Objective To investigate the effects of piperlongumine (PL) and vitamin C (VC) on signal transducer and activator of transcription 3 (STAT3) signalling in gastric cancer cell lines. Methods In vivo tumour xenograft anticancer assays were undertaken to confirm the anticancer activity of PL. Cell viability, flow cytometry and Western blot assays were undertaken to evaluate the anticancer effects of PL, VC and combinations of PL and VC in AGS and KATO III cells. Results Both PL and VC induced apoptosis and inhibited cell proliferation in AGS and KATO III cells. These effects were dependent on reactive oxygen species (ROS). PL effectively suppressed STAT3 activation while VC caused abnormal activation of STAT3. The combination of PL and VC exhibited a stronger apoptotic effect compared with either agent alone. PL reversed the abnormal activation of STAT3 by VC, which could be a key to their synergistic effect. Conclusions PL combined with VC exhibited a stronger anticancer effect by regulating the ROS–STAT3 pathway, suggesting that this combination might be a potential adjuvant therapy for gastric cancer.
Spatial distribution patterns of tick community structure in sympatric jaguars (Panthera onca) and pumas (Puma concolor) from three ecoregions in Mexico

We examined tick communities on wild felid hosts in three ecoregions of Mexico. We collected 186 ticks of 7 species from 10 pumas (Puma concolor) and 9 jaguars (Panthera onca). Tick community composition varied across the ecoregions, and across host species within each region. Overall, Ixodes affinis, Amblyomma ovale, and Amblyomma tenellum were the most abundant species; however, only the latter two ticks were distributed across all three ecoregions, while I. affinis, along with Ixodes spinipalpis, Amblyomma inornatum, and Amblyomma parvum were restricted to more limited geographical regions. Ixodes affinis occurred strictly in southern tropical rainforest ecoregions and was significantly more abundant in Selva Lacandona compared with the Yucatán Peninsula. Amblyomma ovale was significantly more common in the tropical dry forest in the Pacific coastal ecoregion. Amblyomma tenellum abundance tended to be higher on jaguars, while I. affinis abundance was higher on pumas. Regional distribution patterns of some tick species (e.g., I. affinis and I. spinipalpis) may be determined by off‐host environmental conditions rather than host factors. In contrast, at the local scale, occurrence and abundance of some tick species (e.g., A. tenellum, A. ovale and Rhipicephalus microplus) might be driven by ecological‐host factors, such as habitat use or predator–prey relationships.
Common Sense Model program on illness perceptions in patients with impaired awareness of hypoglycemia

Background: Illness perceptions are important for patients with insulin-treated type 2 diabetes mellitus (T2DM) and impaired awareness of hypoglycemia (IAH), as they determine health-related behaviors and motivations. Patients with IAH in many countries have poor illness perception, and there is a paucity of research exploring the effectiveness of Common Sense Model (CSM)-based interventions in this population. Objective: To investigate the effects of a CSM-based intervention program on perceptions of illness in patients with insulin-treated T2DM and IAH. Design: Quasi-randomized controlled trial. Methods: 78 patients with IAH receiving routine care were included. The intervention group (n = 39) participated in a CSM-based program, whereas the control group (n = 39) did not. Illness perceptions, coping styles, hypoglycemia fear, and awareness of hypoglycemia at baseline, 1, and 3 months were analyzed and compared between the two groups. Results: The intervention group exhibited significant improvements in consequences (β = -1.615, P = 0.032); personal control (β = −1.897, P = 0.006); treatment control (β = −1.274, P = 0.046); and positive coping style (β = 4.872, P = 0.002) at the 3-month follow-up, and timeline (β = 2.769, P = 0.004) at the 1-month follow-up. Hypoglycemia fear and awareness were not significantly improved in the intervention group compared with the control group. No intervention-related adverse events were observed. Conclusions: A CSM-based intervention program can modify illness perceptions to an extent and improve the positive coping style in patients with IAH. Impact statementNurses should conduct a CSM-based intervention program to help patients with IAH improve illness perceptions.
Coupled-line directional coupler with tunable power division ratio and operating frequency

This study presents a novel planar coupled-line directional coupler with tunable both power division ratio and operating frequency, which is achieved using microstrip technology for the first time. Its tunability of the operating frequency and the power division ratio, or coupling ratio, can be independently controlled by the bias voltages. Moreover, it can simultaneously maintain perfect port match and isolation. On the basis of the even–odd mode analysis method, both the closed-form analytical equations and parameter discussions are provided to facilitate the practical design. An experimental prototype of the tunable coupler is simulated, fabricated, and measured to demonstrate how it works. The measured results indicate that power division ratio can vary from 0.35 (9 dB) to 0.71 (3 dB) when operating frequency ranges from 0.55 to 1.48 GHz (91.63%) while power division ratio varies from 0.35 (9 dB) to 1 (0 dB) when operating frequency is fixed at 1 GHz, which validated the reliability of the proposed model.
PicassoNet: Searching Adaptive Architecture for Efficient Facial Landmark Localization

Since recent facial landmark localization methods achieve satisfying accuracy, few of them enable fast inference speed, which, however, is critical in many real-world facial applications. Existing methods typically employ complicated network structure and predict all the key points through uniform computation, which is inefficient since individual facial part might take different computation to obtain the best performance. Taking both accuracy and efficiency into consideration, we propose the PicassoNet, a lightweight cascaded facial landmark detector with adaptive computation for individual facial part. Different from the conventional cascaded methods, PicassoNet integrates refinement submodules into a single network with group convolution, where each convolution group predicts landmarks from an individual facial part. Note that the groups’ structures are flexible in the training process. Then, a novel grouping search algorithm is proposed to optimize the group division. With formulating the optimization as a network architecture search (NAS) problem, the grouping search adaptively allocates computation to each group and obtains an efficient structure. In addition, we propose a boundary-aware loss to optimize along tangent and normal of facial boundaries, instead of optimizing along horizontal and vertical as the conventional loss (L2, SmoothL1, WingLoss, and so on) do. The novel loss improves the joint locations of predicted keypoints. Experiments on three benchmark datasets AFLW, 300W, and WFLW show that the proposed method runs over $6\times $ times faster than the state of the arts and meanwhile achieves comparable accuracy.
Social work, Parkinson’s disease care, and COVID-19

ABSTRACT Parkinson’s Disease is a neurological disease affecting over 10 million people worldwide. Interdisciplinary teams provide integrated care to people with Parkinson’s Disease, including care for non-motor symptoms such as anxiety and depression, and many of these teams include social workers. This study sought to learn more about (a) clinical social work utilization across the continuum of care of PWP and their family care partners and (b) how patterns in utilization and service provision have shifted during the pandemic. This mixed method study identifies the breadth of roles performed by social workers in the comprehensive care of people with Parkinson’s Disease (PWP). Findings underscore the important roles social workers play in providing comprehensive care for PWP and their families and their contributions to interdisciplinary teams providing holistic, integrated care, particularly during COVID-19 and into the future.