Miracle-dz/UniFAR-FTUs huggingface dataset:
Face-specific negative bias of aesthetic perception in depression: Behavioral and EEG evidence

Introduction Symptoms of depression are associated with the dysfunction of neural systems such as the emotion, reward system, and the default mode network. These systems were suggested by the model of neuroaesthetics as key contributions to aesthetic experience, leading to the prediction of atypical aesthetic orientation in depression. Here we investigated the aesthetic characteristics of depression and the corresponding neural underpinnings. Methods Fifty-two (25 depression patients, 27 healthy controls) participants were asked to make aesthetic judgments on faces and landscapes in an electroencephalographic (EEG) experiment. Results Our results indicate that relative to the controls, the depression tended to give ugly judgments and refrained from giving beautiful judgments, which was observed only for faces but not for landscapes. We also found that the face-induced component N170 was more negative in the depression group than the control group for ugly and neutral faces. Moreover, the aesthetic evaluation of ugly faces was associated with decreased N200 negativity in the depression group than in the control group, while the evaluation of beautiful faces was associated with decreased brain synchronization at the theta band. Discussion These results suggested a face-specific negative aesthetic bias in depression which can help to design and develop aesthetics-oriented schemes in assisting the clinical diagnosis and therapy of depression.
The cytokine milieu of bullous pemphigoid: Current and novel therapeutic targets

Bullous pemphigoid (BP) is the most common autoimmune bullous disease, characterized by severe pruritus and skin blistering. The loss of tolerance against Collagen XVII, also referred to as BP180, is the main pathogenic event of BP, leading to production of IgG autoantibodies which mainly target the juxtamembranous extracellular non-collagenous 16th A (NC16A) domain of BP180. A complex inflammatory network is activated upon autoantibody binding to the basement membrane zone; this inflammatory loop involves the complement cascade and the release of several inflammatory cytokines, chemokines and proteases from keratinocytes, lymphocytes, mast cells and granulocytes. Collectively, these events disrupt the integrity of the dermal-epidermal junction, leading to subepidermal blistering. Recent advances have led to identify novel therapeutic targets for BP, whose management is mainly based on the long-term use of topical and systemic corticosteroids. As an example, targeting type-2 T-helper cell-associated cytokines, such as Interleukin-4 and interleukin-13 has shown meaningful clinical efficacy in case series and studies; targeting IL-17 and IL-23 has also been tried, owing to an important role of these cytokines in the chronic maintenance phase of BP. In this review article, we discuss the complex cytokine milieu that characterized BP inflammation, highlighting molecules, which are currently investigated as present and future therapeutic targets for this life-threatening disease.
Effect of the one-day fasting on cortisol and DHEA daily rhythm regarding sex, chronotype, and age among obese adults

Introduction Physiological and biochemical processes in the human body occur in a specific order and show rhythmic variability. Time dependence characterizes the secretion of cortisol and dehydroepiandrosterone (DHEA). One-day fasting implies alternating fasting days and eating days. The study aimed to determine how 24-h fasting affects the daily rhythm of cortisol and DHEA levels in obese people while taking into account gender and chronotype. Methods Forty-nine obese patients (BMI 32.2–67.1 kg/m2; 25 women and 24 men) underwent a 3-week hospital-controlled calorie restriction diet to reduce body weight. During hospitalization, patients fasted for 1 day, during which only water could be consumed. Samples of whole mixed unstimulated saliva were collected at 2–3-h intervals over a 64-h period and analyzed for cortisol and DHEA by immunoassays. The individual chronotypes were assessed by the morning and evening questionnaire, according to Horne and Östberg. Three components of daily rhythm were evaluated: amplitude, acrophase, and the so-called MESOR. Results Cortisol rhythm showed differences in amplitude (p = 0.0127) and acrophase (p = 0.0005). The amplitude on the fasting day was 11% higher (p = 0.224) than the day after. The acrophase advanced on the day of fasting, 48 min earlier than the day before (p = 0.0064), and by 39 min to the day after fasting (p = 0.0005). In the rhythm of DHEA, differences were found in the MESOR (p = 0.0381). The MESOR on the fasting day increased. Discussion Our results obtained during 64 consecutive hours of saliva sampling suggest that one-day fasting may affect three components of cortisol and DHEA daily rhythm. Additionally, no differences were found in the daily rhythm between the morning and evening chronotypes and between females and males. Although aging did not influence daily cortisol rhythm, DHEA amplitude, MESOR, and acrophase changed with age. To the best of our knowledge, this is the first presentation of changes in DHEA rhythm during one-day fasting.
The effect of knowledge transfer theory on the selection of crossover winter sports athletes: A systematic literature review

This article reviews studies on the knowledge transfer theory (KTT) in sport psychology using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) method to identify any existing research gaps. This review utilizes a systematic process that involves searching for studies aimed at clarifying the relationship between KTT and crossover selection, promoting crossover development of winter sports, and cultivating outstanding athletes across six different databases. This work provides the foundation for future research on KTT in the field of selection of athletes for professional sports and those intending to showcase KTT’s success in the selection of winter sports athletes. This review found that crossover selection of qualified athletes helps solve the issue of the shortage of professional athletes in specific sports.
Acoustic tracking of a threatened juvenile shark species, the smooth hammerhead (Sphyrna zygaena), reveals vulnerability to exploitation at the boundary of a marine reserve

The coastal waters of South Africa are habitat to a diverse composition of sharks that are vulnerable to exploitation, many of which are endemic and/or classified by the International Union for Conservation of Nature (IUCN) Red List as Threatened or Data Deficient. Accordingly, this region has been identified as a global research and conservation priority for elasmobranchs. The De Hoop Marine Protected Area (MPA), in the Western Cape Province of South Africa, provides 288 km2 of no-take protection within its boundaries. However, the region experiences heavy commercial fishing, with two vessels actively operating as dedicated shark longliners (as of 2022). When crossing MPA boundaries, sharks are susceptible to capture by these vessels. Utilizing passive acoustic telemetry, the present study evaluated the movements of a threatened juvenile shark species, the smooth hammerhead (Sphyrna zygaena), both inside and adjacent to the De Hoop MPA, and along the greater coastline. Movement data from 20 tagged sharks were used to explore the effects of spatial, environmental, and management variables on their residency and movement patterns. Results indicate a high reliance of sharks on unprotected waters immediately adjacent to the MPA’s eastern boundary, an area of high biological productivity due to its proximity to the mouth of an estuary. Although some tagged sharks did move regionally along the South African coastline, individuals spent 95% of their days detected just outside the eastern boundary of the MPA, rendering them vulnerable to commercial shark longlining occurring there. These findings have conservation implications for smooth hammerhead sharks in South Africa and present an opportunity to revisit management practices that may optimize spatial protection for an important life stage of this threatened species.
Numerical study of sediment suspension affected by rigid cylinders under unidirectional and combined wave–current flows

Sediment transport modeling for flows with cylinders is very challenging owing to the complicated flow–cylinder–sediment interactions, especially under the combined wave-current flows. In this paper, an improved formulation for incipient sediment suspension considering the effect of cylinder density (i.e., solid volume fraction) is employed to simulate the bottom sediment flux in the flow with cylinders. The proposed model is calibrated and validated using laboratory measurements under unidirectional and combined wave-current flows in previous studies. It is proved that the effects of cylinders on sediment suspension can be accounted for through a modified critical Shields number, and the proposed model is capable of simulating sediment suspension under both unidirectional and combined wave–current flows reasonably well with the average the coefficients of determination and model skills greater than 0.8 and 0.64.
Evolution of total column ozone prior to the era of ozone depletion

Total column ozone has been monitored for almost a century. The focus of most research studies over the last 40 years was on the era of ozone depletion and the detection of signs of recovery. However, the question also arises to what extent total column ozone has changed prior to this era. Possible causes could be changes in ozone production (both in the troposphere and stratosphere) due to changing atmospheric composition, changes in solar activity, or climatic changes. In this contribution, I discuss the evolution of total column ozone in the 40 years from 1924, when ozone monitoring started, to 1963, which is approximately the time when ozone depletion started to affect the ozone layer. Using long historical measurements, as well as an assimilated zonal mean total column ozone dataset, I show that variability was characterized by strong interannual-to-multiannual anomalies, with a small positive trend at the northern mid-to high-latitudes of ca. 6 DU over the 40-year period. The latitudinal pattern of the trend matches that found in CMIP6 models, but the trend at mid-latitudes is weaker than that in the models.
Electrically-evoked responses for retinal prostheses are differentially altered depending on ganglion cell types in outer retinal neurodegeneration caused by Crb1 gene mutation

Background Microelectronic prostheses for artificial vision stimulate neurons surviving outer retinal neurodegeneration such as retinitis pigmentosa (RP). Yet, the quality of prosthetic vision substantially varies across subjects, maybe due to different levels of retinal degeneration and/or distinct genotypes. Although the RP genotypes are remarkably diverse, prosthetic studies have primarily used retinal degeneration (rd) 1 and 10 mice, which both have Pde6b gene mutation. Here, we report the electric responses arising in retinal ganglion cells (RGCs) of the rd8 mouse model which has Crb1 mutation. Methods We first investigated age-dependent histological changes of wild-type (wt), rd8, and rd10 mice retinas by H&E staining. Then, we used cell-attached patch clamping to record spiking responses of ON, OFF and direction selective (DS) types of RGCs to a 4-ms-long electric pulse. The electric responses of rd8 RGCs were analyzed in comparison with those of wt RGCs in terms of individual RGC spiking patterns, populational characteristics, and spiking consistency across trials. Results In the histological examination, the rd8 mice showed partial retinal foldings, but the outer nuclear layer thicknesses remained comparable to those of the wt mice, indicating the early-stage of RP. Although spiking patterns of each RGC type seemed similar to those of the wt retinas, correlation levels between electric vs. light response features were different across the two mouse models. For example, in comparisons between light vs. electric response magnitudes, ON/OFF RGCs of the rd8 mice showed the same/opposite correlation polarity with those of wt mice, respectively. Also, the electric response spike counts of DS RGCs in the rd8 retinas showed a positive correlation with their direction selectivity indices (r = 0.40), while those of the wt retinas were negatively correlated (r = −0.90). Lastly, the spiking timing consistencies of late responses were largely decreased in both ON and OFF RGCs in the rd8 than the wt retinas, whereas no significant difference was found across DS RGCs of the two models. Conclusion Our results indicate the electric response features are altered depending on RGC types even from the early-stage RP caused by Crb1 mutation. Given the various degeneration patterns depending on mutation genes, our study suggests the importance of both genotype- and RGC type-dependent analyses for retinal prosthetic research.
IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes

Antecedent group A streptococcal pharyngitis is a well-established cause of acute rheumatic fever (ARF) where rheumatic valvular heart disease (RHD) and Sydenham chorea (SC) are major manifestations. In ARF, crossreactive antibodies and T cells respond to streptococcal antigens, group A carbohydrate, N-acetyl-β-D-glucosamine (GlcNAc), and M protein, respectively, and through molecular mimicry target heart and brain tissues. In this translational human study, we further address our hypothesis regarding specific pathogenic humoral and cellular immune mechanisms leading to streptococcal sequelae in a small pilot study. The aims of the study were to (1) better understand specific mechanisms of pathogenesis in ARF, (2) identify a potential early biomarker of ARF, (3) determine immunoglobulin G (IgG) subclasses directed against GlcNAc, the immunodominant epitope of the group A carbohydrate, by reaction of ARF serum IgG with GlcNAc, M protein, and human neuronal cells (SK-N-SH), and (4) determine IgG subclasses deposited on heart tissues from RHD. In 10 pediatric patients with RHD and 6 pediatric patients with SC, the serum IgG2 subclass reacted significantly with GlcNAc, and distinguished ARF from 7 pediatric patients with uncomplicated pharyngitis. Three pediatric patients who demonstrated only polymigrating arthritis, a major manifestation of ARF and part of the Jones criteria for diagnosis, lacked the elevated IgG2 subclass GlcNAc-specific reactivity. In SC, the GlcNAc-specific IgG2 subclass in cerebrospinal fluid (CSF) selectively targeted human neuronal cells as well as GlcNAc in the ELISA. In rheumatic carditis, the IgG2 subclass preferentially and strongly deposited in valve tissues (n = 4) despite elevated concentrations of IgG1 and IgG3 in RHD sera as detected by ELISA to group A streptococcal M protein. Although our human study of ARF includes a very small limited sample set, our novel research findings suggest a strong IgG2 autoantibody response against GlcNAc in RHD and SC, which targeted heart valves and neuronal cells. Cardiac IgG2 deposition was identified with an associated IL-17A/IFN-γ cooperative signature in RHD tissue which displayed both IgG2 deposition and cellular infiltrates demonstrating these cytokines simultaneously. GlcNAc-specific IgG2 may be an important autoantibody in initial stages of the pathogenesis of group A streptococcal sequelae, and future studies will determine if it can serve as a biomarker for risk of RHD and SC or early diagnosis of ARF.
Optical properties of polymer films with embedded single‐wall carbon nanotubes

In this work the thin polymer films (based on polyvinyl alcohol or carboxymetylcellulose) containing single‐wall carbon nanotubes synthesized by different methods have been fabricated by a novel technology and studied in detail by UV–VIS–NIR optical absorption and Raman scattering techniques. The films are prospective as an optical material with a high non‐linearity. This property allows using them as ultra‐fast saturable absorbers in different laser schemes, especially, in fiber lasers. The optical spectroscopy has been used for optimization of several film parameters: an optical density, a thickness, a level of scattered light and proximity of the film absorption bands to the operation wavelengths of different solid state lasers. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Dreaming during the COVID-19 pandemic: Support for the threat simulation function of dreams

Evolutionary theories suggest that dreams function as a world simulator of events that maximizes our ability to surmount social and threat-related challenges critical to survivorship and reproduction. Here, in contrast to the incorporation continuity hypothesis, we test the (1) social bias hypothesis, which states that dreams will overrepresent positive social interactions relative to waking life, (2) the mutually exclusive threat bias hypothesis, the idea that dream content will be negative relative to waking life, (3) the strengthening hypothesis, which states that dreams will rehearse more positive interactions with individuals the self is familiar with relative to waking life, and (4) the compensation hypothesis, which states that social contents in dreams increases during periods of social seclusion. Dream (n = 168) and wake (n = 184) reports were collected through a standardized online survey from 24 undergraduate students. Recalls were analyzed using the Social Content Scale. Generalized linear mixed effects models were used, and the following fixed-effects were considered for the study; the number of reports contributed, report state, biological sex, stress, social support, and media exposures. Results showed support for the threat bias hypothesis, we found that dreams were more negative and featured more unfamiliar individuals in contrast to waking life. Additionally, we found partial support for the social bias and the strengthening hypotheses, however no support was shown for the compensation hypothesis. Overall, these results demonstrate support for the threat simulation function of dreams.
Advances in application of swept-source optical coherence tomography angiography in diagnosis and treatment of diabetic retinopathy

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the leading causes of global blinding. More attention should be paid to the diagnosis, treatment and prognosis of DR. Swept-source optical coherence tomography angiography (SS-OCTA) is a novel imaging technique presented in recent years. It can accurately present the various levels of the retina, choriocapillaris, macula, and the optic papillary microcirculation, which is new to the diagnosis and prognosis of DR. However, SS-OCTA is limited by poor fixation or severe media clouding and is susceptible to motion artefacts and segmentation errors. Future limitations need to be addressed and large prospective trials conducted to refine the relevance of SS-OCTA to DR. The present study reviews the advances in clinical application of SS-OCTA in diagnosis, treatment and prognosis of DR.
Age differences in psychological distress during the COVID-19 pandemic: March 2020 – June 2021

In March 2020, COVID-19 brought illness, lockdowns, and economic turmoil worldwide. Studies from March–April 2020 reported increased psychological distress, especially among younger (vs. older) adults. Here, we examine whether age differences persisted in a 29-wave longitudinal survey conducted with an American national life-span sample over the first 16 months of the pandemic. Socio-emotional selectivity theory (SST) predicts that older age will be consistently associated with lower psychological distress due to life-span changes in motivation, while the strength and vulnerability integration model (SAVI) posits that age differences in psychological distress will diminish under prolonged stress. We find that younger adults consistently reported more psychological distress than older adults, though age differences did decrease over time. Prior diagnosis with anxiety or depression additionally predicted greater psychological distress throughout the study, but did not moderate age differences. We discuss implications for psychological theories of aging and interventions to reduce psychological distress.
Adaptation and initial psychometric study of the anxiety and fear of COVID-19 scale in the United Kingdom population

Objective The aim of the study was the initial psychometric study to validate the anxiety and fear of COVID-19 (AMICO) assessment scale in the general population of the United Kingdom population. Materials and methods A descriptive, cross-sectional, psychometric validation and descriptive study was conducted, performing univariate and bivariate analyses, as well as exploratory and confirmatory factor analysis. Results The sample was 658 people living in the United Kingdom over 16 years. Of the total, 80.5% were female, with a mean age of 48.25 years (SD = 14.861). A mean score for the AMICO scale of 4.85 (SD = 2.398) was obtained, with a range of scores from 1 to 10. The study of percentiles and quartiles allowed for the identification of three proposed levels of anxiety. Conclusion The AMICO_UK scale is reliable to measure the presence of anxiety and fear related to the COVID-19 disease in the United Kingdom population. The majority of the United Kingdom population presented low levels of anxiety and fear at the time the scale was administered.
Genetic and morphological variants of Acidovorax avenae subsp. avenae cause red stripe of sugarcane in China

Sugarcane (Saccharum spp.) is an important cash crop for production of sugar and bioethanol. Red stripe caused by Acidovorax avenae subsp. avenae (Aaa) is a disease that occurs in numerous sugarcane-growing regions worldwide. In this study, 17 strains of Aaa were isolated from 13 symptomatic leaf samples in China. Nine of these strains produced white-cream colonies on nutrient agar medium while the other eight produced yellow colonies. In pairwise sequence comparisons of the 16S-23S rRNA internally transcribed spacer (ITS), the 17 strains had 98.4-100% nucleotide identity among each other and 98.2-99.5% identity with the reference strain of Aaa (ATCC 19860). Three RFLP patterns based on this ITS sequence were also found among the strains of Aaa obtained in this study. Multilocus sequence typing (MLST) based on five housekeeping genes (ugpB, pilT, lepA, trpB, and gltA) revealed that the strains of Aaa from sugarcane in China and a strain of Aaa (30179) isolated from sorghum in Brazil formed a unique evolutionary subclade. Twenty-four additional strains of Aaa from sugarcane in Argentina and from other crops worldwide were distributed in two other and separate subclades, suggesting that strains of A. avenae from sugarcane are clonal populations with local specificities. Two strains of Aaa from China (CNGX08 forming white-cream colored colonies and CNGD05 forming yellow colonies) induced severe symptoms of red stripe in sugarcane varieties LC07-150 and ZZ8 but differed based on disease incidence in two separate inoculation experiments. Infected plants also exhibited increased salicylic acid (SA) content and transcript expression of gene PR-1, indicating that the SA-mediated signal pathway is involved in the response to infection by Aaa. Consequently, red stripe of sugarcane in China is caused by genetically different strains of Aaa and at least two morphological variants. The impact of these independent variations on epidemics of red stripe remains to be investigated.