Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient Estimation of Autoregression Parameters and Innovation Distributions forSemiparametric Integer-Valued AR(p) Models (Revision of DP 2007-23)

Integer-valued autoregressive (INAR) processes have been introduced to model nonnegative integer-valued phenomena that evolve over time. The distribution of an INAR(p) process is essentially described by two parameters: a vector of autoregression coefficients and a probability distribution on the nonnegative integers, called an immigration or innovation distribution. Traditionally, parametric models are considered where the innovation distribution is assumed to belong to a parametric family. This paper instead considers a more realistic semiparametric INAR(p) model where there are essentially no restrictions on the innovation distribution. We provide an (semiparametrically) efficient estimator of both the autoregression parameters and the innovation distribution.
Outcomes in Patients With COVID-19 With Acute Encephalopathy and Coma

Background and Objectives To report the prevalence of acute encephalopathy and outcomes in patients with severe coronavirus disease 2019 (COVID-19) and to identify determinants of 90-day outcomes. Methods Data from adults with severe COVID-19 and acute encephalopathy were prospectively collected for patients requiring intensive care unit management in 31 university or university-affiliated intensive care units in 6 countries (France, United States, Colombia, Spain, Mexico, and Brazil) between March and September of 2020. Acute encephalopathy was defined, as recently recommended, as subsyndromal delirium or delirium or as a comatose state in case of severely decreased level of consciousness. Logistic multivariable regression was performed to identify factors associated with 90-day outcomes. A Glasgow Outcome Scale–Extended (GOS-E) score of 1–4 was considered a poor outcome (indicating death, vegetative state, or severe disability). Results Of 4,060 patients admitted with COVID-19, 374 (9.2%) experienced acute encephalopathy at or before the intensive care unit (ICU) admission. A total of 199/345 (57.7%) patients had a poor outcome at 90-day follow-up as evaluated by the GOS-E (29 patients were lost to follow-up). On multivariable analysis, age older than 70 years (odds ratio [OR] 4.01, 95% CI 2.25–7.15), presumed fatal comorbidity (OR 3.98, 95% CI 1.68–9.44), Glasgow coma scale score <9 before/at ICU admission (OR 2.20, 95% CI 1.22–3.98), vasopressor/inotrope support during ICU stay (OR 3.91, 95% CI 1.97–7.76), renal replacement therapy during ICU stay (OR 2.31, 95% CI 1.21–4.50), and CNS ischemic or hemorrhagic complications as acute encephalopathy etiology (OR 3.22, 95% CI 1.41–7.82) were independently associated with higher odds of poor 90-day outcome. Status epilepticus, posterior reversible encephalopathy syndrome, and reversible cerebral vasoconstriction syndrome were associated with lower odds of poor 90-day outcome (OR 0.15, 95% CI 0.03–0.83). Discussion In this observational study, we found a low prevalence of acute encephalopathy at ICU admission in patients with COVID-19. More than half of patients with COVID-19 presenting with acute encephalopathy had poor outcomes as evaluated by GOS-E. Determinants of poor 90-day outcome were dominated by older age, comorbidities, degree of impairment of consciousness before/at ICU admission, association with other organ failures, and acute encephalopathy etiology. Trial Registration Information The study is registered with ClinicalTrials.gov, number NCT04320472.
Challenges and chances coexist: A visualized analysis and bibliometric study of research on bioresorbable vascular scaffolds from 2000 to 2022

Background: Bioresorbable scaffolds (BVS) provide a transient supporting force for blocked vessels and allow them to return to previous physiological characteristics. After verification with twists and turns, it has been acknowledged as an emerging revolution in percutaneous coronary intervention that expresses the current concept of intervention without placement. Through this bibliometric study, we organized the knowledge structure of bioresorbable scaffolds and attempted to predict future research hotspots in this field. Methods: seven thousand sixty-three articles were retrieved from the web of science core collection database from 2000 to 2022. Then, we utilize CiteSpace 6.1. R2, Biblioshiny and VOS viewer 1.6.18 to analyze the data visually. Results: First, according to the spatial analysis, the number of annual publications has shown an approximately increasing trend over the past 2 decades. The USA, the People’s Republic of China, and GERMANY published the most articles on bioresorbable scaffolds. Second, SERRUYS P ranked first for his most prolific work and highest cited frequency in this domain. Third, the hotspots in this field can be inferred from the keyword distribution; they were the fabrication technique based on tissue engineering; the factors to be optimized for bioresorbable scaffolds, such as mechanical property, degradation, and implantation; and the common adverse effects of bioresorbable scaffolds, such as thrombosis. Most importantly, in terms of burst detection, we could speculate that cutting-edge technology for manufacturing scaffolds represented by 3D printing constitutes the future hotspots in bioresorbable scaffold development. Conclusion: In the first visualized bibliometric analysis of BVS, we attempt to provide a panoramic view. By enrolling extensive literature, we review the growing trend of BVSs. Since its first introduction, it has been through periods of early prosperity, questioned safety subsequently and the resultantly advanced techniques in recent years. In future, the research should focus on utilizing novel techniques to consummate the manufacturing quality and assure the safety of BVSs.
Large area silicon drift detectors for x-rays -- New results

Large area silicon drift detectors, consisting of 8 mm and 12 mm diameter hexagons, were fabricated on 0.35 mm thick high resistivity n-type silicon. An external FET and a low-noise charge sensitive preamplifier were used for testing the prototype detectors. The detector performance was measured in the range 75 to 25 C using Peltier cooling, and from 0.125 to 6 {micro}s amplifier shaping time. Measured energy resolutions were 159 eV FWHM and 263 eV FWHM for the 0.5 cm{sup 2} and 1 cm{sup 2} detectors, respectively (at 5.9 keV, {minus}75 C, 6 {micro}s shaping time). The uniformity of the detector response over the entire active area (measured using 560 nm light) was < 0.5%.
The Prevalence, Profitability, and Risks of Milking Among Low-End Small Rental Properties

Abstract Low-cost but unsubsidized one- to four-unit rental properties provide a critical source of housing for millions of low- and moderate-income renters. These properties are disproportionately in high-poverty neighborhoods and, until recently, studies of these low-end small rental properties (SRPs) primarily focused on their financial viability. Scholars found that, in general, these properties were marginally profitable at best and carried serious financial risks. Recently, however, studies have found that low-end SRPs may be as profitable as or even more profitable than properties in lower-poverty neighborhoods, and have suggested that these profits are driven by exploitative management. I surveyed the owners and managers of SRPs to understand whether low-end properties were more likely to be profitable and whether the owners who did achieve profits at the low end used “milking” strategies. I found that SRPs in high-poverty neighborhoods are about as likely to be profitable as the rest of the market, but are also financially riskier. I found no compelling evidence of a link between profit and more exploitative management practices at the low end of the market. These findings call for a change in policymakers’ understanding of profit and exploitative management among low-end SRPs.
Resting State EEG Correlates of Suicide Ideation and Suicide Attempt

Suicide is a global phenomenon that impacts individuals, families, and communities from all income groups and all regions worldwide. While it can be prevented if personalized interventions are implemented, more objective and reliable diagnostic methods are needed to complement interview-based risk assessments. In this context, electroencephalography (EEG) might play a key role. We systematically reviewed EEG resting state studies of adults with suicide ideation (SI) or with a history of suicide attempts (SAs). After searching for relevant studies using the PubMed and Web of Science databases, we applied the PRISMA method to exclude duplicates and studies that did not match our inclusion criteria. The selection process yielded seven studies, which suggest that imbalances in frontal and left temporal brain regions might reflect abnormal activation and correlate with psychological distress. Furthermore, asymmetrical activation in frontal and posterior cortical regions was detected in high-risk depressed persons, although the pattern in the frontal region was inverted in non-depressed persons. The literature reviewed suggests that SI and SA may be driven by separate neural circuits and that high-risk persons can be found within non-depressed populations. More research is needed to develop intelligent algorithms for the automated detection of high-risk EEG anomalies in the general population.
Replication of Rocio virus in primary cultures of mouse neural cells

ABSTRACT Objective This study verified the replication efficiency of the Rocio virus in a primary culture of mouse neural cells. Methods Mixed primary cultures (neurons/glia) obtained from the brains of newborn isogenic BALB/c mice were inoculated with Rocio virus on the 7 th day of culture, and the development of cytopathogenic effects was monitored. The infection was confirmed via immunocytochemistry (anti-ROCV), while viral replication was quantified in infected primary cultures. The titration method used depended on the infection period. Results Rocio virus efficiently infected primary cultured neural cells, with the highest viral titer causing cytopathic changes was observed at 2 days post infection. The virus-infected primary culture survived for up to 7 days post infection, and viral load quantitation showed viral replication kinetics compatible with the cell death kinetics of cultures. Conclusion The findings of this study suggest that mouse neural cell primary cultures support Rocio virus replication and could be used as an alternative system for studying Flavivirus infection in the central nervous system.
Maximum Penalized Likelihood Estimation: Volume II Regression

Unique blend of asymptotic theory and small sample practice through simulation experiments and data analysis. Novel reproducing kernel Hilbert space methods for the analysis of smoothing splines and local polynomials. Leading to uniform error bounds and honest confidence bands for the mean function using smoothing splines Exhaustive exposition of algorithms, including the Kalman filter, for the computation of smoothing splines of arbitrary order.
Postprocessing of MRIs Using FreeSurfer in Epilepsy Surgery Patients Provides an Excellent Imaging Marker of Hippocampal Sclerosis but Fails to Separate Subtypes

Objective. Histopathological examinations will diminish as minimally invasive epilepsy surgery increasingly replaces open surgery. The objective of this study was to test if visual and computer-aided quantitative analyses of presurgical high-quality 3 Tesla MRIs complying with the International League Against Epilepsy (ILAE) Neuroimaging Task Force recommendations can inform on histopathological diagnosis. Methods. Ninety-two patients from Copenhagen and Oslo University Hospitals fulfilled patient-, imaging-, and histopathological inclusion criteria: 69 patients were diagnosed with hippocampal sclerosis (HS) ILAE type 1 or 2, and 23 patients had normal appearing hippocampi or other histopathology than HS (no-HS). MRIs from 52 healthy controls (HC) were included. Image processing was performed in FreeSurfer v.6. 0 with the built-in cross-sectional hippocampal subfield segmentation tool and multimodal MRI input. Volume outputs were used to calculate volume asymmetry ratios (VARs) for whole hippocampus (WH) and subfields. Results. HS patients had significantly larger WH VARs compared to no-HS patients and HC, with a sensitivity = 0.93 and specificity = 1.0 for histopathological HS diagnosis. Visual MRI assessment yielded a sensitivity = 0.90 and specificity = 0.96 for histopathological HS diagnosis. CA1 and CA4 VARs and the number of seizure-free patients were not significantly different in HS ILAE type 1 compared to type 2 patients. Significance. FreeSurfer analyses of presurgical MRIs are excellent at separating patients histopathologically diagnosed with HS from patients with other pathology or normal appearing hippocampi. Using the FreeSurfer hippocampal subfield segmentation tool did not allow for separating HS ILAE subtypes.
Free vibration of horizontally curved thin-walled beams with rectangular hollow sections considering two compatible displacement fields

ABSTRACT A finite element is presented for vibration analyses of horizontally curved thin-walled rectangular hollow beams. Eight cross-section deformation modes are employed to describe the mid-surface contour displacement field with the modal superposition method. Focused on the in-plane moment equilibrium condition and the displacement continuity condition, two compatible displacement fields are constructed to calculate the strain energy and the kinetic energy of the beam, respectively. With the application of Hamilton’s principle the dynamic governing equations are formulated, and then approximated for the finite element implementation. Finally, numerical examples are illustrated to verify the validity of the present theory.
Associations of Baseline Sleep Microarchitecture with Cognitive Function After 8 Years in Middle-Aged and Older Men from a Community-Based Cohort Study

Purpose Prospective studies examining associations between baseline sleep microarchitecture and future cognitive function recruited from small samples with predominantly short follow-up. This study examined sleep microarchitecture predictors of cognitive function (visual attention, processing speed, and executive function) after 8 years in community-dwelling men. Patients and Methods Florey Adelaide Male Ageing Study participants (n=477) underwent home-based polysomnography (2010–2011), with 157 completing baseline (2007–2010) and follow-up (2018–2019) cognitive assessments (trail-making tests A [TMT-A] and B [TMT-B] and the standardized mini-mental state examination [SMMSE]). Whole-night F4-M1 sleep EEG recordings were processed following artifact exclusion, and quantitative EEG characteristics were obtained using validated algorithms. Associations between baseline sleep microarchitecture and future cognitive function (visual attention, processing speed, and executive function) were examined using linear regression models adjusted for baseline obstructive sleep apnoea, other risk factors, and cognition. Results The final sample included men aged (mean [SD]) 58.9 (8.9) years at baseline, overweight (BMI 28.5 [4.2] kg/m2), and well educated (75.2% ≥Bachelor, Certificate, or Trade), with majorly normal baseline cognition. Median (IQR) follow-up was 8.3 (7.9, 8.6) years. In adjusted analyses, NREM and REM sleep EEG spectral power was not associated with TMT-A, TMT-B, or SMMSE performance (all p>0.05). A significant association of higher N3 sleep fast spindle density with worse TMT-B performance (B=1.06, 95% CI [0.13, 2.00], p=0.026) did not persist following adjustment for baseline TMT-B performance. Conclusion In this sample of community-dwelling men, sleep microarchitecture was not independently associated with visual attention, processing speed, or executive function after 8 years.
ANALYSIS OF RISK FACTORS RELATED TO THE EVENT OF STUNTING IN TODDLERS IN CENTRAL BENGKULU REGENCY

Background : Stunting is a growth and development disorder in children due to chronic malnutrition and repeated infections, which is characterized by a length or height that is below the standard. The prevalence of stunting under five in Bengkulu Province based on the results of the 2021 SSGI is 22.1% and the prevalence of stunting toddlers in Central Bengkulu Regency is 25.5%. This study aims to analyze the risk factors associated with the incidence of stunting in Pagar Jati District, Central Bengkulu Regency. Methods : Analytical observational method with a cross-sectional design approach. The sample is children aged 12-59 months in the sub-district of the priority locus of stunting prevention in Central Bengkulu Regency, totaling 50 samples. Data analysis used Chi-Square test with 95% confidence level (? =0,05%). Results : The results of the statistical test of the Exclusive Breastfeeding variable obtained a p value of 0.010 <0.05, meaning that there is a relationship between Exclusive Breastfeeding and Stunting Incidence in Pagar Jati District, Central Bengkulu Regency, the mother's knowledge of nutrition variable obtained a p value of 0.003 < 0, 05, meaning that there is a relationship between Mother's Knowledge of Nutrition and Stunting Incidence in Pagar Jati District, Central Bengkulu Regency and the sanitation hygiene variable obtained p value of 0.001 < 0.05, meaning that there is a relationship between sanitation hygiene and Stunting Incidence in Pagar Jati District, Central Bengkulu Regency. Conclusion : Exclusive breastfeeding, mother's knowledge about nutrition and sanitation hygiene has a relationship with the incidence of stunting in Pagar Jati District, Central Bengkulu Regency. It is recommended to mothers of Toddlers to actively participate in Posyandu activities and check the growth and development of Toddlers on a regular basis.
Analysis of Frames with Partial Connection Rigidity

A computer oriented method is described for the analysis of frames with partially rigid beam-to-column connections. The moment-rotation relationship for the partially rigid connections is approximated by a bilinear model. Slopes of these models are graphically determined and used to define connection rigidities. Element stiffness matrices are derived which include the effect of these partial rigidities. The modified element stiffness matrices are then used in a direct stiffness method of solution. Analysis for stability of frames with partial connection rigidity is carried out using the classical method of determining bifurcation states. The modified element stiffness matrices incorporating the effects of partial connection rigidities are directly used in the analysis. Problems ranging from rigid frames to pin connected frames can be solved by the same appproach and examples are presented to show the results.
Quotients of primes

This note is motivated by our answer, appearing herein as Theorem 4, to the following question posed in a communication from our colleague William Vince Grounds: Given positive real numbers a V. When X is a topological space then the least cardinality of a dense subset of X is one among several interlocking measures of the 'poverty' of the topology on X. For instance, a topological space with a countable dense subset is called separable. These traits are 'topological invariants', and are fundamental to the classification of topological spaces. It is well-known that lR under the usual topology is separable, and indeed that the denumerable set F(N) is dense in the subspace lR'. Theorem 4 states that F(P') is dense in Rll. If S is a finite subset of RN1 then F(S) is finite, and therefore F(S) fails to be dense in X for every infinite subspace X of 1R.
Factors Associated with the Occurrence of Pneumonia in Children Under Five in Tarus, Central Kupang, East Nusa Tenggara

Background: Pneumonia is an acute infection that attacks the lung tissue (alveoli) caused by various microorganisms such as viruses, fungi and bacteria. The risk factors for pneumonia are environmental factors, individual child factors, and behavioral factors. Environmental factors include indoor air pollution, physical condition of the house, and residential density. Individual child factors include age, gender, nutritional status, low birth weight, immunization and breast-feeding. Behavioral factors include smoking habits, habit of opening and closing windows, and habit of cleaning the house. The study aimed to analyze the factors associated with the incidence of pneumonia in children under five in Tarus Village, Central Kupang, East Nusa Tenggara. Subjects and Method: An analytic survey study with a cross-sectional design was conducted in the Tarus Village, Kupang Tengah, Kupang, East Nusa Tenggara from August to September 2022. A total of 88 mothers of children under five aged 12-59 months in the Tarus Village, Kupang Tengah District, Kupang Regency, East Nusa Tenggara were selected for this study. The dependent variable is the incidence of pneumonia in children under five. The independent variables are the type of floor, lighting, ventilation, occupancy density, smoking habit, habit of opening windows, and habit of cleaning the house. Data were collected using a questionnaire and analyzed using the chi-square test. Results: There is a relationship between house ventilation (OR= 5.83; 95% CI= 1.05 to 1.34; p= 0.003), house floor (OR= 4.65; 95% CI= 1.57 to 1.77; p= 0.001), house lighting (OR= 6.22; 95% CI= 1.09 to 1.25; p= 0.005), occupancy density (OR= 6.90; 95% CI=1.18 to 1.37; p= 0.001), window opening behavior (OR= 5.34; 95% CI= 1.26 to 1.46; p = 0.004), and house cleanliness (OR= 8.55; 95% CI= 1.07 to 1.22; p= 0.002) on the incidence of pneumonia. Conclusion: House ventilation, house floors, lighting, occupancy density, window opening behavior, and house cleanliness are significantly related to the incidence of pneumonia.
Therapeutic Effects of microRNAs on Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH): A Systematic Review and Meta-Analysis

Nonalcoholic fatty liver disease (NAFLD) has emerged as a global health problem that affects people even at young ages due to unhealthy lifestyles. Without intervention, NAFLD will develop into nonalcoholic steatohepatitis (NASH) and eventually liver cirrhosis and hepatocellular carcinoma. Although lifestyle interventions are therapeutic, effective implementation remains challenging. In the efforts to establish effective treatment for NAFLD/NASH, microRNA (miRNA)-based therapies began to evolve in the last decade. Therefore, this systematic review aims to summarize current knowledge on the promising miRNA-based approaches in NAFLD/NASH therapies. A current systematic evaluation and a meta-analysis were conducted according to the PRISMA statement. In addition, a comprehensive exploration of PubMed, Cochrane, and Scopus databases was conducted to perform article searches. A total of 56 different miRNAs were reported as potential therapeutic agents in these studies. miRNA-34a antagonist/inhibitor was found to be the most studied variant (n = 7), and it significantly improved the hepatic total cholesterol, total triglyceride, Aspartate Aminotransferase (AST), and Alanine Transaminase (ALT) levels based on a meta-analysis. The biological processes mediated by these miRNAs involved hepatic fat accumulation, inflammation, and fibrosis. miRNAs have shown enormous therapeutic potential in the management of NAFLD/NASH, wherein miRNA-34a antagonist has been found to be an exceptional potential agent for the treatment of NAFLD/NASH.