Miracle-dz/UniFAR-FTUs huggingface dataset:
ACELL February 47/2

Territo, Paul R. , Vamsi K. Mootha, Stephanie A. French, and Robert S. Balaban. Ca21 activation of heart mitochondrial oxidative phosphorylation: role of the F0/F1ATPase. Am. J. Physiol. Cell Physiol. 278: C423–C435, 2000. —Ca21 has been postulated as a cytosolic second messenger in the regulation of cardiac oxidative phosphorylation. This hypothesis draws support from the well-known effects of Ca21 on muscle activity, which is stimulated in parallel with the Ca21-sensitive dehydrogenases (CaDH). The effects of Ca21 on oxidative phosphorylation were further investigated in isolated porcine heart mitochondria at the level of metabolic driving force (NADH or Dc) and ATP production rates (flow). The resulting force-flow (F-F) relationships permitted the analysis of Ca21 effects on several putative control points within oxidative phosphorylation, simultaneously. The F-F relationships resulting from additions of carbon substrates alone provided a model of pure CaDH activation. Comparing this curve with variable Ca21 concentration ([Ca21]) effects revealed an approximate twofold higher ATP production rate than could be explained by a simple increase in NADH or Dc via CaDH activation. The half-maximal effect of Ca21 at state 3 was 157 nM and was completely inhibited by ruthenium red (1 μM), indicating matrix dependence of the Ca21 effect. Arsenate was used as a probe to differentiate between F0/F1-ATPase and adenylate translocase activity by a futile recycling of ADP-arsenate within the matrix, catalyzed by the F0/F1-ATPase. Ca21 increased the ADP arsenylation rate more than twofold, suggesting a direct effect on the F0/F1ATPase. These results suggest that Ca21 activates cardiac aerobic respiration at the level of both the CaDH and F0/F1-ATPase. This type of parallel control of both intermediary metabolism and ATP synthesis may provide a mechanism of altering ATP production rates with minimal changes in the high-energy intermediates as observed in vivo.
CATEGORY : Plants Interacting with Other Organisms Defense activated by 9-lipoxygenase-derived oxylipins requires specific mitochondrial proteins

Centro Nacional de Biotecnología-CSIC, Campus Universidad Autónoma, Cantoblanco, E-28049 Madrid, Spain; and 1 Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden. 2 Present address: Energy Biosciences Institute, University of California, Berkeley, CA 94720, USA. 3 Present address: Syngenta CP, CH-4332 Stein, Switzerland. * To whom correspondence should be addressed. Carmen Castresana; Centro Nacional de Biotecnología, CSIC, Campus Universidad Autónoma, Cantoblanco, E-28049 Madrid, Spain; phone 34-91-5854564; fax 34-915854506; e-mail: ccastresana@cnb.csic. es.
CONTRIBUTIONS Los Angeles Study of Residential Magnetic Fields and Childhood Brain Tumors

A measurement study of residential magnetic fields and brain tumors in children that was added onto an ongoing case-control interview study in Los Angeles County, California, included 298 children under age 20 years with a primary brain tumor diagnosed from 1984 to 1991 and 298 control children identified by random digit dialing. Magnetic fields were determined for all Los Angeles homes where these 596 children lived from conception to diagnosis (1,131 homes) by mapping and coding the wiring configurations outside the home and by taking a series of exterior spot and profile measurements. In addition, for a subset of subjects (35%; 211 homes) 24-hour measurements were taken in the child's room and one other room. Although measured fields are consistently highest in the highest of the five wire code categories, fields in homes in this category are much lower in Los Angeles than in Denver, where the code originated. Brain tumor risk appears not to relate to measured fields inside (p for trend for child's room = 0.98) or outside (p for trend for front wall = 0.82) the home. An apparent increase in risk among children living at diagnosis in homes with underground wiring appears to be an artifact introduced by using current controls for historical cases because this apparent excess risk disappeared in an analysis restricted to the later years of the study when cases and controls were accrued concurrently. Our study does not show an overall association of pediatric brain tumors with measured fields, with "very high" wiring configurations, or with any of several other potential sources of exposure, such as use of various electrical appliances, but the prevalence of high fields (>2 mG) and very high fields (>3 mG) in Los Angeles homes was too low to detect a moderate effect of the magnitude reported in other studies. Am J Epidemiol 1996; 143:105-19.
ORR_A_339064 209..214

1Department of Rehabilitation Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Abstract: Distal upper extremity weakness is a rare complication after herpes zoster, which can be easily misdiagnosed by other nerve entrapment syndromes. We present a 31year-old immunocompromised woman who developed a claw-like deformity of her right hand after full medical treatment and resolution of herpes zoster. The electrodiagnostic finding was compatible with right multiple mononeuropathies of the median and ulnar nerves, ongoing axonal loss, unlike the nerve entrapment patterns. The early recognition and early electrodiagnosis of herpes zoster-induced distal motor weakness, especially in the upper extremity, is necessary to exclude the nerve entrapment syndrome and to be the baseline for functional motor recovery prediction. The prognosis of functional motor recovery is considered good but may take months to years to accomplish. Rehabilitation management plays an important role after full medical treatment.
FIRST REPORT OF BOTRYTIS RESISTANCE IN RED BERRIES FRUIT TOWARDS FENHAXAMID AND FLUDIOXONIL + CYPRODINIL MIXTURE, AND ITS SENSITIVITY FEATURE TOWARDS OTHER SINGLE SITE FUNGICIDES IN MOROCCO

In this study single spores of seven B. cinerea isolates were collected from red-berries farms in the Loukkos and Gharb regions, North of Morocco, to evaluate their sensitivity to four commercial anti-botrytis fungicides registered in the country. All four fungicides contain different active ingredients namely: Iprodione, Fenhexamid, Thiophanatemethyl and mixture of Fludioxonil and Cyprodinil. Two main experiments were established in vitro for anti-Botrytis inhibitory assay; radial mycelia growth and spore germination inhibition tests at different concentrations. Fungicidal tests showed that all strains of B. cinerea were sensitivities to Iprodione with EC50 values (the effective concentrations to cause inhibition by 50%) ranging from 0.008 to 0.34 ppm inhibiting mycelia growth, and between 0.007 and 0.27 ppm inhibiting conidia germination. However, Fenhexamid did not show the same efficacy since all strains were resistant with EC50 values all higher than 5 ppm. For Thiophanate methyl, Botrytis strains responded differently to this product. Indeed, only 12.5% of strains were sensitive. EC50 values ranging from 83.28 to 2185.66 ppm for mycelia growth and from 73.17 to 3573.01 ppm for conidia germination. However, only 37.5% of the strains have shown sensitivity to Fludioxonil + Cyprodinil mixture with EC50 values ranging from 0.01 to 67.70 ppm for mycelial growth and between 0.001 and 5.81 ppm for conidia germination. These data may explain the non-efficacy of anti-Botrytis fungicides application in gray mold control in red berries fields in Morocco and highlights the need for new strategies for Botrytis management in different red-berries culture.
Analysis of Phenolic , Flavonoid and Antioxidant Activity of Moringa oleifera ( Lam . ) Root

Moringa oleifera (Lam.) (Moringaceae) is commonly known as drumstick and it’s the best source of nutrition and used as a traditional medicine for various ailments. Antioxidant activity Moringa oleifera (Lam.) roots was identified as an active principle against DPPH, superoxide, ABTS. +, nitric oxide, hydrogen peroxide radicals and also showed highest inhibition scavenging effect on reducing power, hydroxyl radical and also have potent Fe2+ metal chelating activity. The total phenolic and flavonoids content were also evaluated and found to be 55.26 ± 1.04 mg/g expressed in Gallic acid equivalents (GAE) and 200.62 ± 3.30 mg/g quercetin equivalent respectively. The present work revealed the active principle against free radicals in the methanol extract of Moringa oleifera root.
Market impact in a latent order book

In this article we revisit the classical problem of market impact, reviewing the recent literature both empirical and theoretical. We propose a new agent-based model where market participants follow a mean-reversion process. Our model, inspired from [DBMB], draws from the so-called mean (cid:28)eld approach in Statistical Mechanics and Physics ([Lasry and Lions]). It assumes that a large number of (cid:16)agents(cid:17) interact in the order book and by taking the (cid:16)continuum limit(cid:17) (when the number of agents goes to in(cid:28)nity), we obtain a set of nonlinear partial di(cid:27)erential equations. And we explicitly solve them using Fourier analysis. One could talk as well of a (cid:16)micro-macro(cid:17) approach of equilibrium, where the market price is the consequence of each ((cid:16)microscopic(cid:17)) agent behaving with respect to his preferences and to global ((cid:16)macroscopic(cid:17)) information. This model accomodates very well the concept of market impact, leading to an integral equation satis(cid:28)ed by the impacted price. We prove the existence of a solution to this integral equation. And we establish that the impact of a metaorder decreases when either the volatility of the underlying asset or the agents’ reassesment intensity increases. In addition, we give various limiting cases, examples and possible extensions.
The Systematics of Intracluster Starlight

Surveys for intracluster planetary nebulae and red giants have been performed in a variety of cluster environments, from the well-mixed regions of the Virgo and Fornax Clusters, to the low-density areas of the M81 Group. When coupled with the results of Abell Cluster surface photometry and intracluster supernova detections, these surveys provide clues to the systematics of the intracluster light phenomenon. We analyze the results of the intracluster surveys performed to date and show how the fraction of intracluster stars depends on parameters such as cluster richness and rate of galaxy interaction. We also compare our results to numerical predictions and discuss avenues for future research.
Poised chromatin at the ZEB1 promoter enables cell plasticity and enhances tumorigenicity

Christine L Chaffer1,*, Nemanja D Marjanovic1,*, Tony Lee1, George Bell1, Celina G Kleer2, Ferenc Reinhardt1, Ana C D'Alessio1, Richard A Young1,3, and Robert A Weinberg1,4 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA 2University of Michigan Medical School, Department of Pathology, Ann Arbor MI, 48109, USA 3Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 4Ludwig MIT Center for Molecular Oncology, Cambridge, MA 02139, USA
Short title: Sonoelastography in healthy knee tendon Title: Reliability of strain sonoelastography in the assessment of the quadriceps and patellar tendon in healthy adults

Short title: Sonoelastography in healthy knee tendon Title: Reliability of strain sonoelastography in the assessment of the quadriceps and patellar tendon in healthy adults. Diane M Dickson1*, Henrietta Fawole1, Lisa Newcombe1, Stephanie L Smith1, Gordon J Hendry1 1Glasgow Caledonian University, School of Health and Life Sciences, Glasgow, UK. DM Dickson, Senior Lecturer, Musculoskeletal Health PhD Student, MSc SL Smith, Musculoskeletal Health Research Fellow, PhD L Newcombe, Lecturer in Podiatry, PhD H Fawole, Musculoskeletal Health PhD student, MSc GJ Hendry, Musculoskeletal Health Senior Research Fellow, PhD *Reprints and Correspondence DM Dickson, A366, Glasgow Caledonian University School of Health and Life Science Cowcaddens Road Glasgow Scotland, UK G4 0BA T: +44 (0)141 273 1396| F: +44 (0)141 273 1396 | E: Diane.Dickson@gcu.ac. uk No financial support or other benefits have been obtained from commercial sources for the work reported on in the manuscript. There are no other financial interests that any of the authors may have, which could create a potential conflict of interest or the appearance of a conflict of interest with regards to this work.
COPD_A_305380 2165..2179

1National Health and Medical Research Council Centre for Research Excellence in Severe Asthma, Newcastle, NSW, Australia; 2The Priority Research Centre for Health Lungs, The University of Newcastle, Newcastle, NSW, Australia; 3School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia; 4Hunter Medical Research Institute, Newcastle, NSW, Australia; 5Department of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, Newcastle, NSW, Australia; 6School of Nursing and Midwifery, The University of Newcastle, Newcastle, NSW, Australia Purpose: The clinical and inflammatory associations of mast cells (MCs) and basophils in chronic obstructive pulmonary disease (COPD) are poorly understood. We previously developed and validated a qPCR-based MC/basophil gene signature in asthma to measure these cells in sputum samples. Here, we measured this gene signature in a COPD and control population to explore the relationship of sputum MCs/basophils to inflammatory and COPD clinical characteristics. Patients and Methods: MC/basophil signature genes (TPSAB1/TPSB2, CPA3, ENO2, GATA2, KIT, GPR56, HDC, SOCS2) were measured by qPCR in sputum from a COPD (n=96) and a non-respiratory control (n=17) population. Comparative analyses of gene expression between the COPD and the control population, and between eosinophilic COPD and non-eosinophilic COPD were tested. Logistic regression analysis and Spearman correlation were used to determine relationships of sputum MC/basophil genes to inflammatory (sputum eosinophil proportions, blood eosinophils) and clinical (age, body mass index, quality of life, lung function, past year exacerbations) characteristics of COPD. Results: MC/basophil genes were increased in COPD versus control participants (CPA3, KIT, GATA2, HDC) and between eosinophilic-COPD and non-eosinophilic COPD (TPSB2, CPA3, HDC, SOCS2). We found all MC/basophil genes were positively intercorrelated. In COPD, MC/basophil genes were associated with eosinophilic airway inflammation (GATA2, TPSB2, CPA3, GPR56, HDC, SOCS2), blood eosinophilia (all genes) and decreased lung function (KIT, GATA2, GPR56, HDC). Conclusion: We demonstrate associations of MCs and basophils with eosinophilic inflammation and lower lung function in COPD. These findings are consistent with prior results in asthma and may represent a new tool for endotyping eosinophilic-COPD.
OP followed by involved field radiation: Is it optimal for localized nasal natural killer/T-cell lymphoma?,

\ The present study aimed to analyse the treatment outcome of four cycles of CHOP (cyclophosphamide-vincristine-doxorubicin-prednisolone) followed by involved field radiation therapy (IF RT) for the treatment of stage I—II nasal natural killer (NK)/T-cell lymphoma. From March 1995 to December 1999, 17 patients (median age 41 years; range 30-66) with localized nasal NK/T-cell lymphoma were enrolled. B symptoms were noted in five patients (31%). Sixteen of seventeen patients (94%) were of low risk when classified according to the International Progresponses (PRs) were achieved (53% of response rate). IF RT was given to six patients (four in CR, one in PR and one in PD), and all six patients achieved CR. Overall, CR was achieved in 10 of 17 patients (58%). The planned sequential chemoradiotherapy was completed in only 6 of 17 patients (35%) because of the progression during chemotherapy. None of the patients who achieved CR experienced relapse of lymphoma during follow-up. The estimated overall three-year survival rate was 59%. In univariate analysis, B symptoms and stage were significant prognostic factors for response and overall survival (P < 0.05). The present study suggests that four cycles of CHOP nostic Index (IPI). /^followed by IF RT is not satisfactory for treating patients with The treatment plan consisted of four cycles of CHOP/ localized nasal NK/T-cell lymphoma, and that further explochemotherapy followed by IF RT of 45 Gy. Two patients ration for improved therapy is needed. received radiation during the first or second cycle of CHOP because of bleeding from the primary tumour site. Both patients achieved complete responses (CRs). In the remaining 15 patients, after 4 cycles of CHOP, 6 CRs and 3 partial
Human Cervix Contains Functional Luteinizing Hormone/Human Chorionic Gonadotropin Receptors

The upper genital tract of women contains functional LH/ human chorionic gonadotropin (hCG) receptors. Whether the cervix, an anatomical continuum of the uterus and fallopian tubes, also contains these receptors has never been investigated. Multiple receptor detection techniques revealed their presence with higher levels in endocervix than in ectocervix. The receptor positive cells include stratified squamous luminal epithelium of the ectocervix, columnar epithelium, glands, blood vessels, and smooth muscle in the endocervix. Treatment of cervical tissue minces with hCG resulted in a significant increase in cAMP levels and a decrease in cyclooxygenase-2 protein levels in endocervix, but not in ectocervix. In summary, human cervix contains functional LH/hCG receptors, which suggests that LH during the menstrual cycle and hCG during pregnancy may regulate cervical functions. (J Clin Endocrinol Metab 88: 3409–3414, 2003)
Measurement of the Decays $B^0_s\to J/\psi\,\phi(1020)$, $B^0_{s}\to J/\psi\,f'_2(1525)$ and $B^0_s\to J/\psi\,K^+K^-$ at Belle

We report a measurement of the branching fraction of the decay $B^0_s\to J/\psi\,\phi(1020)$, evidence and a branching fraction measurement for $B^0_s\to J/\psi\,f'_2(1525)$, and the determination of the total $B^0_s\to J/\psi\,K^+K^-$ branching fraction, including the resonant and non-resonant contributions to the $K^+K^-$ channel. We also determine the $S$-wave contribution within the $\phi(1020)$ mass region. The absolute branching fractions are $\mathcal{B}[B^0_s\to J/\psi\,\phi(1020)]=(1.25 \pm 0.07\left(\mathrm{stat}\right)\pm 0.08\left(\mathrm{syst}\right)\pm 0.22\left(f_s\right))\times 10^{-3}$, $\mathcal{B}[B^0_s\to J/\psi\,f'_2(1525)]=(0.26\pm 0.06\left(\mathrm{stat}\right)\pm 0.02\left(\mathrm{syst}\right) \pm 0.05\left(f_s\right))\times 10^{-3}$ and $\mathcal{B}[B^0_s\to J/\psi\,K^+K^-] = (1.01\pm 0.09\left(\mathrm{stat}\right) \pm 0.10\left(\mathrm{syst}\right)\pm 0.18\left(f_s\right))\times 10^{-3}$, where the last systematic error is due to the branching fraction of $b\bar{b}\to B^{(*)}_s B^{(*)}_s$. The branching fraction ratio is found to be $\mathcal{B}[B^0_s\to J/\psi\,f'_2(1525)]/\mathcal{B}[B^0_s\to J/\psi\,\phi(1020)]=(21.5\pm 4.9\left(\mathrm{stat}\right) \pm2.6\left(\mathrm{syst}\right))%$. All results are based on a 121.4 fb$^{-1}$ data sample collected at the $\Upsilon(5S)$ resonance by the Belle experiment at the KEKB asymmetric-energy $e^+e^-$ collider.
De Novo Transcriptome of the Hemimetabolous GermanCockroach (Blattella germanica)

Background: The German cockroach, Blattella germanica, is an important insect pest that transmits various pathogens mechanically and causes severe allergic diseases. This insect has long served as a model system for studies of insect biology, physiology and ecology. However, the lack of genome or transcriptome information heavily hinder our further understanding about the German cockroach in every aspect at a molecular level and on a genome-wide scale. To explore the transcriptome and identify unique sequences of interest, we subjected the B. germanica transcriptome to massively parallel pyrosequencing and generated the first reference transcriptome for B. germanica. Methodology/Principal Findings: A total of 1,365,609 raw reads with an average length of 529 bp were generated via pyrosequencing the mixed cDNA library from different life stages of German cockroach including maturing oothecae, nymphs, adult females and males. The raw reads were de novo assembled to 48,800 contigs and 3,961 singletons with highquality unique sequences. These sequences were annotated and classified functionally in terms of BLAST, GO and KEGG, and the genes putatively coding detoxification enzyme systems, insecticide targets, key components in systematic RNA interference, immunity and chemoreception pathways were identified. A total of 3,601 SSRs (Simple Sequence Repeats) loci were also predicted. Conclusions/Significance: The whole transcriptome pyrosequencing data from this study provides a usable genetic resource for future identification of potential functional genes involved in various biological processes. Citation: Zhou X, Qian K, Tong Y, Zhu JJ, Qiu X, et al. (2014) De Novo Transcriptome of the Hemimetabolous German Cockroach (Blattella germanica). PLoS ONE 9(9): e106932. doi:10.1371/journal.pone. 0106932 Editor: Yara M. Traub-Csekö, Instituto Oswaldo Cruz, Fiocruz, Brazil Received February 6, 2014; Accepted August 10, 2014; Published September 29, 2014 This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Funding: This study was supported by the grants from China Postdoctoral Science Foundation (2013M530727), Beijing Municipal Postdoctoral Scientific Research Foundation (2013ZZ-94) and Public Welfare Industry Scientific Research Foundation of National General Administration of Quality Supervision, Inspection and Quarantine (201310255-02). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * Email: qiuxh@ioz.ac. cn (XQ); xpzeng@126.com (XPZ)
Identification and Characterization of a Unique Tumor-associated Surface Antigen on LI 210 Leukemia Cells Recognized by Semisyngeneic Antisera1

The tumor-associated surface antigen on 1.1210 leukemia cells was studied by immunofluorescence staining and immunoprecipitation. AntiLi 210 serum was prepared in BALB/c x DBA/2 I, mice by priming with a hybrid of L1210 and human Lesch-Nyhan fibroblast cells and hyperimmunizing with 1.1210 leukemia cells. This hyperimmune serum was able to demonstrate specific surface fluorescence on L1210 cells, while the antiserum did not react with various mouse tumor cell lines, normal lymphoid tissues, or mitogen-activated lymphoid cells. The anti1.12111serum immunoprecipitated a single polypeptide with a molecular weight of 90,000 from '"1-labeled L1210 cells. The expression of this antigen was enhanced by tumor-promoting agent and heat shock treat ment. The biological significance of the LI2Hi-specific cell surface antigen is discussed.