Miracle-dz/UniFAR-FTUs huggingface dataset:
CONSEQUENCES OF ELASTIN GENE MUTATIONS IN AUTOSOMAL DOMINANT CUTIS LAXA AND SUPRAVALVULAR AORTIC STENOSIS

Extracellular matrix (ECM) and associated molecules have a myriad of roles comprising cell-cell communication, cell proliferation, migration, cell differentiation, development and survival. Elastic fibers are major insoluble components of ECM that are vital for connective tissues including large arteries, skin, lung, ligaments, and auricular cartilage. Their function is to provide elastic stretch and recoil to the conncevtive tissues. Elastin (ELN) is the key insoluble protein in the elastic fibers and it is the primary provider of elasticity and resilience. Structural abnormalities in elastin lead to a decrease in the integrity of elastic tissues including skin, lungs and large blood vessels. Therefore, elastin gene mutations lead to several skin, cardiovascular and pulmonary phenotypes including Williams Beuren syndrome, autosomal dominant cutis laxa (ADCL) and supravalvular aortic stenosis (SVAS). ADCL is characterized by loose and inelastic skin, pulmonary emphysema, aortic root dilation, and peripheral pulmonary aortic stenosis. SVAS is characterized by narrowing of the ascending aorta. While ADCL is caused by the frameshift mutations at the 3’ end of the ELN gene, missense and truncation mutations throughout the ELN gene lead to SVAS. In this review, we discussed and compared the latest information including clinical presentation, mutational spectrum and molecular mechanisms in ADCL and SVAS.
Nitrogen effect on the growth and yield contributing characters of Binadhan-19

The experiment was conducted at the BINA sub-station, Rahmatpur, Barishal, during the period from April 2020 to August 2020 to investigate the effect of nitrogen on the yield of transplant Aus rice cv. Binadhan-19. The experiment comprised four levels of nitrogen viz (a) N0 (zero nitrogen), (b) N1 (90 kg N/ha), (c) N2 (110 kg N/ha) and (d) N3 (130 kg N/ha). Nitrogen fertilizer was applied at two splits. The experiment was laid out in a randomized complete block design with three replications. Results revealed that plant height, effective tiller, non-effective tiller, flag leaf length, filled gran, unfilled grain and 1000 grain weight were increased with increasing nitrogen doses till 110 kg N ha-1. Furthermore, the highest grain weight was recorded in 110 kg N ha-1 due to superior performance of yield contributing characters of BInadhan-19. A positive correlation was found between grain yield and total dry matter production. The experimental results concluded that 110 kg N ha-1 would be the best dose for higher gain yield in Binadhan-19 in aus season.
Motivation and commitment of English student teachers of some Universities in Indonesia

Teachers play crucial roles; therefore, this study is intended to examine student teachers’ motivation (instrumental vs. integrative) and commitment (committed passionate, committed compromiser, undecided and uncommitted) to teaching. Quantitative approach using a questionnaire was conducted involving 328 English student teachers from some universities in Indonesia. Using the descriptive analysis, the findings show that those having integrative motivation are 56% and the highest figure for the level of commitment is, as expected, committed passionate (44%). Concerning gender differences, more males (M: 60%, F: 55%) were surprisingly found to have integrative motivation, although more females were found to have the highest level of commitment (M: 35%, F: 47%). These findings at the same time reveal a considerably high proportion of those who did not have a genuine motive to enroll in a teacher education programme and to commit to becoming teachers implying necessary measures from both the government and the teacher education institutions. Keywords: Commitment, motivation, student teacher, teacher, teacher education.
Limitations of Immunohistochemistry in Diagnosis of a Primary Mucinous Carcinoma of the Skin and Its Metastasis

We describe the case of a 67-year-old female patient who presented with an unclear swelling on the right supraclavicular neck, two years after resection of a mucinous carcinoma on the right mastoid. Two pathological reports from separate universities diagnosed the primary mastoid skin lesion as a metastatic adenocarcinoma. Strikingly, GATA binding protein 3 (GATA3) and mammaglobin, both immunomarkers found in breast cancer, were positive. An urgent search for the primary tumor most likely in the breast was commenced. However, as no other primary tumor could be detected at that time, a Primary Mucinous Carcinoma of the Skin (PMCS) was also debated. Two years later neck node enlargement was suspicious for lymph node metastasis during ultrasound examination and conservative neck dissection was performed. Immunohistochemistry revealed again GATA 3, Mammaglobin, estrogen, and progesterone receptor positive tissue. Using a variety of other markers, we were unable to detect neither significant morphological nor immunohistochemical characteristics that distinguished the lesion from a mucinous carcinoma of mammary origin. Following a detailed review of the clinical context, we concluded the lesion to be consistent with a late metastasis of a PMCS. This report demonstrates the limitations of currently used histopathological and immunohistochemical differentiation in metastatic mucinous carcinoma.
Determination of Some Air Pollutants andMeteorological Parameters in Abattoir, NTAK INYANG in UYO L.G.A of AKWA IBOM State in Nigeria

Department of Science Technology, AKWA IBOM State Polytechnic, IKOT Osurua, AKWA IBOM State, Nigeria. ABSTRACT The determination of air pollutants in Abattoir, Ntak Inyang in Uyo L.G. A was carried out using standard analytical techniques. The pollutants monitored were NO2, SO2, H2S, CO, NH3, Cl2, TVOC, CH2O, PM2.5, PM10, Temp, Relative humidity (RH), Pressure and Wind Speed (WS). The results for the concentration of air pollutant and their Air Quality Index (AQI) reveals as follows NO2 (1.36 ± 0.32(ppm), AQ1=1360). SO2 (2.44 ± 1.98(ppm), AQ1=488). H2S (3.38 ± 1940(ppm), AQ1=19450). CO (1.79±1.61(ppm), AQ1=334). NH3 (7.8±2.26(ppm), AQ1=156). Cl2 (1.47± 1.29(ppm), AQ1= 147). HCN (11.56±7.93(mg/m ), AQ1=115,600). TVOC (164±0.46(mg/m), AQ1=328). CH2O (0.23±0.12(mg/m ), AQ1=0.276). PM2.5 (43.2±0.95(μg/m ), AQ1=172.8). PM10 (74.8±1.15(μg/m ), AQ1=149.6). Temp (27.5±4.6C). Relative humidity (RH) (74.6 ± 4.6%), Press (1006.7±0.84(kpa). W.S (1.56±0(m/s)). The result showed that NO2, SO2, H2S, CO, NH3, Cl2, HCN, TVOC, PM2.5 and PM10 were higher than that of FEPA standard limit. The correlation analysis revealed that NO2 shows positive relationship with H2S, and W.S at 0.05 significant level and negatively with Cl2 and Press at 0.01 significant level, and negatively with PM2.5 and PM10 at 0.05 significant level. SO2 correlated positively with CO at 0.01 significant level, TVOC and CH2O at 0.05 significant level. SO2-NH3 at 0.05 significant level but negatively. H2S shows a relationship with Temp but positively at 0.01 significant level and 0.05 significant level with HCN, H2S also correlated negatively with NH3 and Press at 0.01 significant level. While CO shows a correlation with NH3 at 0.05 significant level but negatively. NH3-RH positively at 0.01 significant, NH3-Press at 0.05 significant level. Also, NH3 shows a negative relationship with TVOC, CH2O and Temp at 0.05 significant level. Cl2 correlated strongly but positively with Press at 0.01significant level, Cl2-PM2.5 and PM10 at 0.05 significant level and a negative relationship with W.S at 0.05 significant level. HCN-WS negatively at a 0.05 significant level. TVOC correlated positively with CH2O and negatively with RH at 0.01 significant level, and a positive relationship with PM2.5 and PM10 at 0.05 significant level. CH2O correlated negatively with RH at 0.01 significant level and positively with PM2.5 and PM10 at 0.05 significant level. PM2.5 shows a positively relationship with PM10 at 0.01 significant level. This result in an indication of the presence of possible air pollutants in the of the study area which may results in many health problems.
Behaviour of Share Prices Around Ex-Split Day of Stock Splits in India

Stock split is a corporate decision in which company divides face value of the equity share into more than one unit. Theoretically stock splits should not have any effect on share prices and stock returns. The present study has attempted to examine the behaviour of share prices around the ex-split day of the stock splits announcement. This effect of stock splits announcements on the share prices is studied by analysing the behaviour of abnormal returns around stock splits of 304 companies listed on BSE, during the period 1999 to 2018. The analysis stresses on finding whether stock splits have an impact on share prices. This impact of stock splits is studied using abnormal returns. The event study is a methodology used to study share price behaviour around specific events and share price reaction to such events as stated by Binder (1998). This effect has been analysed around the event ex-split day. To test the impact of stock splits AAR (Average Abnormal Returns) and ACAR (Average Cumulative Abnormal Returns) are computed. The presence of positive AARs with significant Z -values on t-1 day in pres ex-split day window implies that informed traders anticipating a price increase on ex-split day buy shares before the ex-split day to make fast profit. In post-ex-split day window positive AARs with significant Zsvalues are present on t+1 day probably because of lower share prices after ex-split day. The AARs are negative with significant Z -values in post event s window till t . It implies that in the Indian stock market there is presence of +17 significant negative wealth effect in post ex-split day window not in line with findings of Angel (1997) and Schultz (2000) . ACARs are negative and **
Evaluation of thermogravimetric analysis as a rapid tool for the detection of rhizobacteria biostimulants used in precision agriculture

Six-week-old root samples were evaluated using high resolution (maximum resolution [MaxRes]) thermogravimetric analyses (TGA) of the cell wall compositions of Gram-positive (Bacillus mucilaginosus, Bacillus amyloliquefaciens, and Bacillus subtilis) and Gram-negative (Burkholderia sp., Rahnella aquatilis strain H 2.6, and R. aquatilis strain RC 2.5) root colonizing plant growth promoting rhizobacteria (PGPR) commercial inoculant strains (biostimulants) applied to pot grown wheat plants. TGA discriminated the strains within the two types of rhizobacterial cohorts and thus provided a rapid non-molecular means for the detection of PGPR inoculant biostimulants within hours of root sampling. The latter was due to the greater degree of definition of TGA fingerprints of individual thermal weight loss events occurring over a degradation range, and heightened the corresponding peak temperature divergences within strains of either type of bacteria themselves for their unequivocal identification. Confirmation of biostimulant rhizobacteria identity in concomitant root samples was achieved through either cultural methods or direct tissue PCR molecular protocols within 5 days and 2 days of sampling, respectively. The results suggested that MaxRes TGA could serve as a rapid, inexpensive stand-alone tool or as combinatorial utility alongside pyrolysis gas chromatography mass spectra, and Fourier transform infrared analytics for the early detection of PGPR biostimulants in precision farming.
Effectiveness of active transportation on muscular endurance of school boys and girls of Chandigarh

The purpose of the study was to compare the muscular endurance among different mode of travelling groups (motorized, cyclist and walkers) of Chandigarh school boys and girls. The study was carried out of 3000 school boys (1500) and Girls (1500) of Chandigarh. The age of the subjects ranged between 1317 years. A survey type study had been designed to compare the muscular endurance among different mode of travelling groups of Chandigarh school boys and girls. Initially simple random sampling technique was used for the selection of schools from the government and private schools of Chandigarh. To find out the significance differences among different mode of travelling groups, analysis of variance (ANOVA) was applied with the help of SPSS software. For testing hypothesis, the level of significance was set at 0.05. Further Scheffe’s Post-hoc test was applied to see the direction and significances of differences where ‘F’ratio was found significant. The findings of the study revealed that Cyclists group of school boys and girls were significantly superior to their counterparts.
AIRPORT SERVICE QUALITY: A RECONCEPTUALIZATION AND A PRACTICAL APPLICATION ON THE NON-AERONAUTICAL SERVICES

In line with the advancing airway capability, the non-aeronautical business opportunities at airports are also in growth. To attract more passengers or to generate extra income over non-aeronautical services, the airport decision-makers need to evaluate the quality of their services. This study aims at introducing an expanded approach to improve airport service quality aspects of the non-aeronautical business opportunities. Given the increasing number of airports, passengers prefer airports, which provide better or extra services compared to others. To reveal the airport service quality (ASQ) aspects, together with the quality department experts, we conducted a qualitative study that put forward six significant dimensions for an effective evaluation of airport service quality at an airport. Based on the results of the qualitative study, we designed the sector-specific questionnaire, and its empirical data is conducted over 250 passengers through a face-toface survey. Survey results introduce a practical assessment tool for the use of airport managers to gather strategic inputs on their strategic plans and quality implications. Results also contribute to the literature by presenting a comprehensive understanding of the airport service quality.
Comparison of deep learning convolutional neural network (CNN) architectures for CT lung cancer classification

Lung cancer has become one of the most common deaths amongst the cancer patients. World Health Organisation states that lung cancer is the second most fatal cancer all over the world in 2014. Alarmingly, most of the lung cancer patients are diagnosed at the later stages where the cancer has spreads. Thus, early screening via Computed Tomography scan particularly among active smokers is encouraged. Manual diagnosis of the cancer is made feasible through the integration of Computer Aided Diagnosis system. For the past few years, deep learning method leads most of the artificial based intelligence applications including CAD systems. This paper aims to investigate the performance of five newly established Convolutional Neural Network architectures; GoogleNet, SqueezeNet, DenseNet, ShuffleNet and MobileNetV2 to classify lung tumours into malignant and benign categories using LIDC-IDRI datasets. Their performances are measured in terms of accuracy, sensitivity, specificity and area under the curve of the receiver operating characteristic curve. Experimental results show that GoogleNet is the best CNN architecture for CT lung tumour classification wih an accuracy of 94.53%, specificity 99.06%, sensitivity of 65.67% and AUC 86.84%.
Study on concrete proportioning methods: a qualitative and economical perspective

The various approaches, established for concrete mix design, are not universal because design mixes are explicit to local climate, available materials, and type of exposure. The new-generation mix design method should be developed based on the performance criteria. The concrete strength obtained from the designed concrete mix and optimum cement content should not be considered as the only parameter for the suitability of the concrete mix. This study was carried to compare the proportioning of concrete mixes obtained by following procedures of Indian Standard (IS), American Concrete Institute (ACI) and British Standard (BS) of concrete mix design without the use of admixtures to validate for use in a moderate climate like Kashmir, India. The concrete mixes have been prepared with the necessary 28 days resistance in compression as “15 MPa, 20 MPa, 25 MPa, 30 MPa and 35 MPa”. The assessment of water-cement (w/c) ratio; cement, water, fine aggregate (FA) and coarse aggregate (CA) proportion was carried. The w/c ratio among all formulated mixes is significantly high in the BS method and low for IS method. The BS method uses less quantity and IS method uses the maximum quantity of cement. In addition, the ratio of total aggregate content (TAC) and the aggregate-cement ratio is higher in BS design method as compared to IS and ACI design methods. The aggregate content in ACI mix design appears to be consistent and it added to the relative high compressive strength. The specimens cast following BS guidelines failed to attain the target mean strength (TMS) due to a higher volume of aggregate content, high w/c proportion, less quantity of cement in the mix. The specimens cast by ACI and IS mix design upon compression testing showed higher results than the calculated TMS. The cost analysis per cubic meter of concrete revealed that IS and ACI mix proportioning are expensive than BS method. The IS procedure results in dense concrete followed by ACI procedure. It is expected that with a comprehensive investigation on selected design parameters concentrating more on local challenges, the present study will floor the way for the development and adoption of performance-based design mix selection for moderate climate.
Choroidal Thickness and Correlations with Intraocular Pressure and Spherical Equivalent in Young Myopic Eyes without Maculopathy

Background: Refractive error is one of the causes of visual impairment worldwide, among which myopia is the most common. Myopia is prevalent worldwide, particularly in East and Southeast Asia, which have myopia prevalence rates of approximately 80-90% and high myopia prevalence rates of 10-20% in young adults. High myopia is closely related to a variety of pathological changes and a higher risk of blinding complication. Purpose: To identify the distribution of choroidal thickness (CT) and to determine whether there are associations between subfoveal choroidal thickness (SFCT) and intraocular pressure (IOP) and spherical equivalent (SE) in young healthy myopes without maculopathy. Methods: A total of 116 young subjects without maculopathy were recruited in this study and underwent comprehensive ophthalmic examinations. Enhanced depth imaging spectral domain optical coherence tomography was performed for CT measurement and assessment. SFCT, as well as CT at 3 mm nasal, temporal, superior and inferior to fovea were measured. Univariable linear regression analysis and Multiple regression analysis were used to study the correlation between SFCT and spherical equivalent (SE) as well as IOP. To assess the CT at each location and explore it’s associated factors. Results: The SFCT of high myopes was notably thinner (197.00±35.21 µm) compared with mild myopes (287.05±68.31 µm) and moderate myopes (251.13±64.40µm). For all three groups, CT at 3 mm nasal was the thinnest (195.21±52.43µm, 168.43±59.24µm, 129.56±30.97µm, respectively.) Univariable linear regression analysis indicated that SFCT decreased by 15.49 µm per diopter in myopic refractive change (P <0.001, R2 = 0.146) and decreased by 17.87 µm per 1mmHg increase inintraocular pressure (IOP) (P < 0.001, R2 = 0.440). Multiple regression analysis indicated that there were significantly correlations between SFCT and spherical equivalent (SE) as well as IOP in mild myopes and moderate myopes, but not in high myopes. Conclusions: A significant difference of the CT distribution was found in the centre region among myopes. However, nasal choroid thinning was the most obvious in all myopia groups. SFCT was significantly correlated with IOP and SE in the myopic population. However, the same correlation was not observed in young highly myopic eyes.
Effect of ACT on Work Procrastination and Work Performance

The purpose of this study was to investigate the effect of Acceptance and Commitment Therapy (ACT) on university employees' work procrastination and work performance. This was an experimental study with pretest-posttest control group design. In this study selected 56 employees by Krejcie & Morgan (1970) technique. They were completed Work procrastination(Metin, Taris, & Peeters, 2016) and work performance(McColl, Paterson, Davies, Doubt, & Law, 2000) questionnaires. Then 24 participants who got a high score in work procrastination and low score in work performance were chosen. They were then randomly assigned into experimental and control groups. After that, the experimental group participated in 7 sessions of acceptance and commitment therapy and the control group received no intervention. Both groups were given pre-test and post-test before and after the intervention, respectively. Data were analyzed using descriptive statistics (mean and standard deviation) and inferential statistics (multivariate analysis of variance). Results indicated that the treatment had a significant effect on reducing work procrastination (F =6.57; P < 0.05), but had no effect on work performance.
Target Blood Pressure Goals for Treating Hypertension in the Elderly: A Review

The 2015 Global Burden of disease study[1] reported that high systolic blood pressure (SBP) was one of the largest contributors to global morbidity and mortality, accounting for 10.2 million (9.16–11.3 million Uncertainty interval [UI]) deaths and 208 million (UI 188–227 million) disability-adjusted life years (DALYs). Most of the burden of high systolic BP (SBP) was due to stroke and ischemic heart disease, with 56.5% (UI 49.0–63.2) and 55.5% (UI 48.0–62.7) of DALYs being attributed to stroke and ischemic heart disease, respectively. The INTERHEART[2] and INTERSTROKE[3] studies also showed similar findings, with hypertension accounting for 34.6% and 17.9% of the population attributable risk for stroke and coronary artery disease, respectively. A systematic review of hypertension in India highlighted the increasing prevalence of hypertension in both rural and urban India. [4] With the decrease in BP levels in the 2018 American Heart Association/American College of Cardiology guidelines[5] and an increase in the number of elderly people, the prevalence of those with hypertension, especially the elderly, is likely to increase. There are a number of controversies in the management of hypertension in the elderly, such as the optimum BP at which there are maximum preventive benefits and at the same time minimal complications, the categorization of the BP stage, to rule out pseudo hypertension, white-coat hypertension, masked hypertension, orthostatic, postprandial hypertension and exclude secondary causes in cases of resistant hypertension, the choice of first-line therapy, and the role of combination therapy. In addition, many factors, such as high prevalence of several comorbidities, poly-pharmacy, frailty and minimal inclusion of the elderly in hypertension trials, and leave a variety of unresolved clinical issues to clinicians who offer treatment for this age group. The purpose of this review article is to address the difficulties of evaluating and treating hypertension in older adults and to analyze the evidence and recommendations of different professional societies.