Miracle-dz/UniFAR-FTUs huggingface dataset:
PERAN PENYULUH PERTANIAN TERHADAP KETERAMPILAN PETANI PADI DI KELOMPOK TANI SIDOMAKMUR IDI DESA DENGKEK KECAMATAN PATI KABUPATEN PATI

Tujuan penelitian adalah untuk mendiskripsikan tingkat keterampilan bertani petani di Kelompok Tani Sidomakmur I, mendiskripsikan kemampuan penyuluh sebagai fasilitator, motivator, edukator dan komunikator, menganalisis pengaruh peran penyuluh sebagai fasilitator, motivator, edukator dan komunikator terhadap keterampilan bertani petani padi di Kelompok Tani Sidomakmur I. Penelitian diadakan pada bulan Desember 2017 di Kelompok Tani Sidomakmur I di Desa Dengkek, Kecamatan Pati, Kabupaten Pati. Metode penelitian yang digunakan adalah survei. Pengambilan sampel menggunakan metode purposive sampling dengan jumlah responden 50 petani. Analisis data menggunakan analisis regresi linier berganda. Hasil penelitian secara serempak maupun parsial peran penyuluh sebagai fasilitator, motivator, edukator dan komunikator berpengaruh nyata terhadap keterampilan petani padi. Kata Kunci : keterampilan, peran penyuluh, petani padi.
Incorporating landscape characteristics in a distance metric for interpolating between observations of stream water chemistry

Papers published in Hydrology and Earth System Sciences Discussions are under open-access review for the journal Hydrology and Earth System Sciences Abstract Spatial patterns of water chemistry along stream networks can be quantified using synoptic or " snapshot " sampling. The basic idea is to sample stream water at many points over a relatively short period of time. Even for intense sampling campaigns, the number of sample points is limited and interpolation methods, like kriging, are commonly 5 used to produce continuous maps of water chemistry based on the point observations from the synoptic sampling. Interpolated concentrations are influenced heavily by how distance between points along the stream network is defined. In this study, we investigate different ways to define distance and test these based on data from a snapshot sampling campaign in a 37-km 2 watershed in the Catskill Mountains region 10 (New York State). Three distance definitions (or metrics) were compared: Euclidean or straight-line distance, in-stream distance, and in-stream distance adjusted according characteristics of the local contributing area, i.e., an adjusted in-stream distance. Using the adjusted distance metric resulted in a lower cross-validation error of the interpolated concentrations, i.e., a better agreement of kriging results with measurements, 15 than the other distance definitions. The adjusted distance metric can also be used in an exploratory manner to test which landscape characteristics are most influential for the spatial patterns of stream water chemistry and, thus, to target future investigations to gain process-based understanding of in-stream chemistry dynamics.
Freshwater Fishes of Mexico

Though Mexico is only one-fifth the size of the continental United States, it is home to nearly two-thirds as many freshwater fishes as those that swim the waters of the United States and Canada combined. Mexico's diverse freshwater fauna can be attributed to the country's highly varied physical geography, a wide latitudinal range, the largest river system in middle America, and, ironically, its oceans many marine groups left the brine for the inland springs and never returned to the sea. No one knew these Mexican freshwaters or the fish that inhabit them better than the late world-renowned ichthyologist Robert Rush Miller. A pioneer of the field, Miller undertook his first field excursion more than fifty years ago and, in the decades following, amassed the information necessary to write the first encyclopedia of Mexican inland ichthyology. Providing keys to more than 500 native species accompanied by detailed distribution maps and illustrations "Freshwater Fishes of Mexico" offers a historical overview of the country's ichthyology, as well as syntheses of the unique biogeography of Mexican fishes and their current conservation status. Organized by family, the species accounts are supplemented with color galleries containing photographs of live fishes in their native environments and natural habitats. Exploring ecological, biological, and taxonomic issues, the book also considers the evolutionary history of the ichthyofauna itself and the human history of the scientists who researched it during the last several centuries. The life's work of Robert Rush Miller, the long-awaited "Freshwater Fishes of Mexico" will be welcomed not only by students of Mexican fishes, but by all ichthyologists working in Central and North America. This book will also find an audience among home aquarium hobbyists, fishery managers, conservation biologists, and environmental planners and managers. "
Development and Validation of a Novel Generic Health-related Quality of Life Instrument With 20 Items (HINT-20)

Objectives Few attempts have been made to develop a generic health-related quality of life (HRQoL) instrument and to examine its validity and reliability in Korea. We aimed to do this in our present study. Methods After a literature review of existing generic HRQoL instruments, a focus group discussion, in-depth interviews, and expert consultations, we selected 30 tentative items for a new HRQoL measure. These items were evaluated by assessing their ceiling effects, difficulty, and redundancy in the first survey. To validate the HRQoL instrument that was developed, known-groups validity and convergent/discriminant validity were evaluated and its test-retest reliability was examined in the second survey. Results Of the 30 items originally assessed for the HRQoL instrument, four were excluded due to high ceiling effects and six were removed due to redundancy. We ultimately developed a HRQoL instrument with a reduced number of 20 items, known as the Health-related Quality of Life Instrument with 20 items (HINT-20), incorporating physical, mental, social, and positive health dimensions. The results of the HINT-20 for known-groups validity were poorer in women, the elderly, and those with a low income. For convergent/discriminant validity, the correlation coefficients of items (except vitality) in the physical health dimension with the physical component summary of the Short Form 36 version 2 (SF-36v2) were generally higher than the correlations of those items with the mental component summary of the SF-36v2, and vice versa. Regarding test-retest reliability, the intraclass correlation coefficient of the total HINT-20 score was 0.813 (p<0.001). Conclusions A novel generic HRQoL instrument, the HINT-20, was developed for the Korean general population and showed acceptable validity and reliability.
continuum of care among hiV-1 positive patients in a single center in italy (2007–2017)

Aim: This study aimed to determine rates of retention in care, viral suppression, and use of antiretroviral therapy (ART) and identify risk factors for loss to follow-up (FU) in an adult cohort from a tertiary teaching hospital in Florence, Italy. Methods: We included all newly diagnosed HIV-infected patients aged . 18 years who were linked to our clinic from July 2007 to December 2015. On July 31, 2017, we evaluated the proportion of patients retained in care, on ART, and having HIV RNA , 50 copies/mL. We assessed predictors of loss to FU through univariate and multivariate analyses. Results: We included 423 patients. By July 2017, 23 (5.5%) patients died, 25 (5.9%) moved to a different center, and 64 (15.1%) were lost to follow-up. Among the remaining 311 patients (73.5%), 96.5% were on ART and 95% had HIV RNA , 50 copies/mL. After adjustment for sex, age at diagnosis, origin, and risk of transmission, our results showed a lower retention rate in those not on ART at the end of the follow-up (adjusted HR [aHR]: 10.33, 95% CI 5.80–18.40, P , 0.001), non-Italians (aHR: 1.69, 95% CI: 0.99–2.89, P = 0.054) and , 35 years old (aHR: 1.85; 95% CI 1.04–3.30, P = 0.037). Conclusion: In our hospital in Florence, we found a gap in retention in care among foreigners, people , 35 years old, and those who were not in treatment at the end of the follow-up. The results of this study may help to identify opportunities for appropriate future interventions.
characteristics of brain functional and structural connectivity in alexithymic students

Background: Alexithymia is a multifaceted personality trait and a risk factor for several mental and physical diseases. Methods: In this study, 21 alexithymic students and 21 nonalexithymic students were recruited from the local university and assigned to the alexithymic group and the control group, respec-tively. Then, the functional connectivity and the structural connectivity among the brain regions of the students were investigated using resting-state functional magnetic resonance imaging (rsfMRI), function connection (FC) analysis, and diffusion tensor imaging (DTI). Results: The rsfMRI results revealed 14 brain regions showing significant differences in the amplitude of low-frequency fluctuations between the two groups. Comparative analysis of the FC and DTI data in these brain regions between the two groups identified altered levels of functional and structural connectivity between the following four pairs of regions in the alexithymic subjects: the right inferior temporal gyrus and the central posterior gyrus, the left temporal gyrus and the insula, and the bilateral superior frontal gyrus and the anterior cingulate gyrus. Conclusion: Compared with single MRI analysis, the multiple MRI analysis identified more precisely the brain regions that could play a key role in the development of alexithymia.
Role of microRNAs in Renal Parenchymal Diseases – A New 2 Dimension 3

Since their discovery in 1993, numerous microRNAs (miRNAs) have been identified in humans 11 and other eukaryotic organisms, and their role as key regulators of gene expression is still being 12 elucidated. It is now known that miRNAs not only play a central role in the processes that ensure normal 13 development and physiology, but they are often dysregulated in various diseases. In this review, we 14 present an overview of the role of miRNAs in normal renal development and physiology, in maladaptive 15 renal repair after injury, and in the pathogenesis of renal parenchymal diseases. In addition, we describe 16 methods used for their detection and their potential as therapeutic targets. Continued research on renal 17 miRNAs will undoubtedly improve our understanding of diseases affecting the kidneys and may also 18 lead to new therapeutic agents. 19
Ultrathin Cu-TCPP MOF nanosheets: a new theragnostic nanoplatform with magnetic resonance/near-infrared thermal imaging for synergistic phototherapy of cancers

Nanostructures based on metal-organic frameworks (MOFs) have promising potential as theragnostic nanoplatforms for phototherapy of cancer cells. However, the MOFs alone are seldom reported to be used as photothermal agents mainly due to their poor near-infrared (NIR) light absorption. Methods: Ultrathin copper-tetrakis (4-carboxyphenyl) porphyrin (Cu-TCPP) MOF nanosheets were prepared by a facile solvothermal route. The photothermal therapy (PTT), photodynamic therapy (PDT), and T1-weighted magnetic resonance (MR) imaging capabilities and the high biocompatibility of these composite nanosheets were evaluated in vitro as well as in vivo in a mouse tumor model. Results: The ultrathin Cu-TCPP MOF nanosheets exhibited 1) strong NIR absorption because of the d-d energy band transition of Cu2+ and the ultrathin characteristic translating into excellent photothermal performance, 2) ability to produce singlet oxygen because of the inherent characteristic of TCPP, and 3) capability for MR imaging because of the unpaired 3d electrons of copper. Conclusion: Our study demonstrated that the Cu-TCPP MOF nanosheets are a promising phototherapy nanoplatform with the synergistic ability for PTT and PDT of cancer, guided by MR and infrared thermal imaging.
Airfields on Antarctic glacier ice

Abstract : The physical characteristics of blue ice ablation areas in Antarctica are described and some representative ablation rates are given. The possibilities for using blue-ice areas as airfields are outlined and exploratory surveys are mentioned. Site details are given for icefields at Mount Howe, Mill Glacier, Patriot Hills, Rosser Ridge, Mount Lechner, S1 near Casey station, and on the Ross Ice Shelf near McMurdo station. The surface roughness of blue ice is discussed, microrelief surveys are presented for Mount Howe and Patriot Hills, and spectral analyses are used to develop relations between bump height and wavelength. U.S. military specifications for the roughness limits of various types of runways are summarized and graphical comparisons are made with the roughness analyses for Mount Howe and Patriot Hills. Special machines for smoothing ice runways are discussed and design specifications are developed. Some notes on ground facilities and ground transport are included. Appendices give discussions of weather patterns in the Transantarctic Mountains and methodology for making spectral analyses of surface roughness. It is concluded that glacier-ice airfields for conventional transport aircraft can be developed at low cost in Antarctica. Recommendations for further work are offered. Keywords: Airfields, Antarctica, Blue ice, Cold regions, Ice, Ice runways, Land ice, Polar cap, Polar regions, Runways.
Measurement of the seasonal and annual variability of total column aerosol in a northeastern U.S. network

A network of multi-filter rotating shadowband radiometers has operated since late 1991 in the northeastern US. The data acquired are simultaneous measurements of total and diffuse horizontal irradiances in six narrowband filtered detectors and one broadband shortwave detector. The direct normal irradiances are calculated from these measurements. These direct data are corrected for cosine response and used to calculate extraterrestrial irradiance (I{sub o}) using the Langley method of regressing the natural logarithm of direct irradiance versus air mass. With frequent determinations of I{sub o}, changes in I{sub o} caused by soiling and filter degradation, for example, can be tracked. Using these I{sub o}`s, total optical depth is calculated for every clear 30-minute period in the record. Consequently, total optical depth may be obtained on a fair number of days throughout the year. Using daily average total optical depth the authors have calculated aerosol optical depths for five wavelengths by subtracting Rayleigh scattering optical depths and Chappuis ozone absorption optical depths at each wavelength. The aerosol pattern at nearly every site is an annual cycle superimposed on a decaying stratospheric loading associated with the Mount Pinatubo volcanic eruption. An attempt is made to remove the volcanic signal using data from another site.
Analysis of wake surfing benefits using a fast unsteady vortex lattice method

The computer simulation framework Flexit is used to analyse the fuel economy benefit of aircraft wake surfing. Wake surfing involves multiple aircraft flying in close formation during cruise conditions to reduce overall induced drag and improve overall fuel efficiency. The aircraft fly in echelon such that the kinetic energy lost in vortices generated by the lead aircraft can be partially recovered by the following aircraft flying in regions of the wake where induced velocities have an upwardly directed vertical component. We build on recent theoretical and flight test work by developing a medium fidelity methodology using Flexit for predicting potential performance benefits of wake surfing. We present results from a specific systematic parametric study that corresponds to a series of recent flight tests with two C-17 transport aircraft to demonstrate the methodology and predict the fuel savings that can be obtained by different arrangements of aircraft in a wake surfing formation. The predictions are compared with the flight test data and the trends observed in our simulations agree with the trends of the full scale tests.
Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life Free study

Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops. Aim: To assess the efficacy and local tolerance after 12 months and patient satisfaction regarding local treatment tolerance and handling at inclusion and after 6 months of PF latanoprost compared to preserved glaucoma eye drops. Methods: This was an international, prospective, and observational real-life study. Up to three visits, one at inclusion and two follow-up visits (one after 6 and one after 12 months) were planned. Efficacy, local tolerance, and patient satisfaction were the main evaluation criteria. Results: Data from 721 patients were available for the statistical analysis. Overall, 64.8% (467/721) of patients switched treatment before inclusion: 62.2% in the preserved and 68.9% in the PF latanoprost group. IOP values were similar between PF latanoprost and preserved eye drops and remained stable at all visits. Ocular signs and symptoms improved after switching to PF latanoprost; the prevalence of conjunctival hyperemia was significantly lower ( P = 0.0015) at both follow-up visits. At follow-up visit 1, 49.5% of the patients who switched to PF latanoprost decreased or stopped the use of artificial tears. Satisfaction regarding tolerance in patients using PF latanoprost improved significantly after the switch from preserved eye drops to PF latanoprost (88.9% and 42.5%, respectively, P , 0.0001). Conclusion: This first real-life study showed that PF latanoprost was as efficacious but better tolerated than preserved eye drops over a sustained period of 12 months, while providing a significantly higher patient satisfaction and potentially allowing improvement in the patient’s daily life.
Psychiatric morbidity in psoriasis: A review

SUMMARY Psoriasis is a common condition, affecting 1.5–2% of the population of industrialized countries. It is important for clinicians to be aware that psoriasis can have a substantial emotional impact on an individual, which is not necessarily related to the extent of skin disease. This review examines current literature addressing the psychological and emotional aspects of psoriasis. A literature search of the MEDLINE (1966–2002) and PsycINFO (1984–2002) computer databases and bibliographies was carried out. Papers selected for the review included English language reviews and all original research relevant to the topic, in the form of randomized controlled trials, cohort studies, case–control studies, cross‐over and uncontrolled clinical trials, patient surveys, quality‐of‐life studies, case series and case reports. Despite significant shortcomings, the available prevalence studies showed uniformly high rates of psychopathology among psoriasis sufferers. The few intervention studies available are summarized and critically discussed. Psoriasis is associated with a variety of psychological problems, including poor self esteem, sexual dysfunction, anxiety, depression and suicidal ideation. The clinical severity of the psoriasis may not reflect the degree of emotional impact of the disease. A number of psychological interventions have shown promise in recent trials. It is important that clinicians consider the psychosocial aspects of this illness.
The impact of hypoxia in pancreatic cancer invasion and metastasis

: Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but also plays an active role in promoting tumor progression, malignancy, and resistance to therapy. Hypoxia signaling is mediated by the hypoxia-inducible factors (HIFs), which are not only stabilized under hypoxia, but also by activated oncogenes or inactivated tumor suppressors under normoxia. Hypoxia is a prominent feature of the tumor microenvironment of pancreatic tumors, also characterized by the presence of a fibrotic reaction that promotes, and is also modulated by, hypoxia. As the mechanisms by which hypoxia signaling impacts invasion and metastasis in pancreatic cancer are being elucidated, hypoxia is emerging as a key determinant of pancreatic cancer malignancy as well as an important target for therapy. Herein we present an overview of recent advances in the understanding of the impact that hypoxia has in pancreatic cancer invasion and metastasis. digest the basement membrane, generating pores that cancer cells use to cross it and reach the stroma (2). Once in the stroma, PDAC cells display invasive directed migration, aided by eMT and the proteolytic activity of invadopodia (3) toward blood (5) or lymphatic vessels to intravasate and disseminate through the circulation. PDAC cells are likely to use invadopodia to cross endothelial basement membranes (4) and reach the circulation. Hypoxia affects the tumor stroma by promoting the profibrotic activity of cancer-associated fibroblasts (6) and pancreatic stellate cells (7), which further increases hypoxia in the tumor microenvironment, and also by promoting the crosstalk between cancer and stromal cells to increase cancer cells invasiveness details). Hypoxia may also affect the recruitment and activation of macrophages (8), which also interact with cancer cells to facilitate invasion, for instance, during intravasation. Hypoxia is a determinant of PDAC invasiveness through the activation of cell autonomous and non-cell-autonomous mechanisms that operate in both cancer and associated stroma.
caT 3 , a prodrug of 13a(s)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the hedgehog signaling pathway, independently of O 6 -methylguanine Dna methyltransferase expression

multiforme (GBM) is a malignant high-grade glioma with a poor clinical outcome. Temozolomide (TMZ) is the first-line GBM chemotherapy; however, patients commonly develop resistance to its effects. Materials and methods: We investigated the antitumor activity of CAT 3 in TMZ-resistant glioblastoma cell lines U251/TMZ and T98G. Orthotopic and subcutaneous mice tumor models were used to investigate the effects of various treatment regimes. Results: We found that PF403, the active metabolite of CAT 3 , inhibited proliferation of both cell lines. PF403 repressed the Hedgehog signaling pathway in the U251/TMZ cell line, reduced O 6 -methylguanine DNA methyltransferase (MGMT) expression, and abolished the effects of the Shh pathway. Moreover, PF403 blocked the Hedgehog signaling pathway in T98G MGMT-expressing cells and downregulated the expression of MGMT. CAT 3 suppressed growth in the U251/TMZ orthotopic and T98G subcutaneous xenograft tumor models in vivo. We also demonstrated that inhibition of the Hedgehog pathway by PF403 counteracted TMZ resistance and enhanced the antitumor activity of TMZ in vitro and in vivo. Conclusion: These results indicate that CAT 3 is a potential therapeutic agent for TMZ-resistant GBM. ,