Miracle-dz/UniFAR-FTUs huggingface dataset:
The American and Canadian wartime godmothers of Belgian soldiers. Joseph de Dorlodot’s Correspondence and Documentation Office (1915-1919)

ABSTRACT Lieutenant Joseph de Dorlodot (1871–1941), a Belgian aristocrat and philanthropist, was the Director of the Belgian Correspondence and Documentation Office in Folkestone, England. This article uses the ‘Joseph de Dorlodot’ archive collection (Archives Générales du Royaume de Belgique, Bruxelles) to investigate the emotional support provided by the Correspondence Office during the First World War. Throughout the conflict, its mission was to facilitate the sending of mail between Belgians, to provide them with legal advice and to offer humanitarian assistance to those who were in material and emotional distress. This was particularly the case of soldiers at the front. In the spring of 1916, the Office set up a mail system between Belgian soldiers and wartime godmothers – ‘marraines’ – from Canada and the USA. Lieutenant de Dorlodot imposed a precise moral and political framework for correspondence, where an intimate space was created in order to strengthen patriotic sentiment on the one hand, and control masculinities and femininities on the other. Through their letter exchanges with soldiers, godmothers participated in the war effort by bringing emotional reinforcement to the front line, from their homes, through a type of caring work often ignored or at least disconnected from any notion of work in the history of the Great War.
Establishment of perennial species useful for soil conservation and as forages

Abstract Field establishment of 11 potentially useful soil conservation/revegetation species comprising three grasses (Dactylis glomerata, Festuca arundinacea, Thinopyrum ponticum), seven legumes (Astragalus cicer, Dorycnium hirsutum, Dorycnium pentaphyllum, Dorycnium rectum, Lotus corniculatus, Lupinus polyphyllus, Medicago sativa), and one herb (Sanguisorba minor) was examined at a low‐moderately fertile, seasonally dry site in the lower North Island from spring 1989 to winter 1991. Final seedling emergence ranged from c. 10% (for D. hirsutum, L. corniculatus, and L. polyphyllus) to c. 100% for S. minor, which was unique in achieving complete emergence. The duration of emergence was 3 (L. polyphyllus) to 13 (D. pentaphyllum, D. rectum) days and emergence of all species was completed within 25 days after sowing. Seedling survival 10 weeks after sowing was 40–90% for all species. An exception was A. cicer (4%) and the reason(s) for its low survival were unknown. Ground covers of M. sativa, S. minor, and T.
Traumatic Fractures of the Thoracic Spine Traumatische Frakturen der Brustwirbelsäule

Abstract The majority of traumatic vertebral fractures occur at the thoracolumbar junction and the lumbar spine and less commonly at the mid-thoracic and upper thoracic spine. In accordance, a high number of articles are dealing with thoracolumbar fractures focusing on the thoracolumbar junction. Nonetheless, the biomechanics of the thoracic spine differ from the thoracolumbar junction and the lumbar vertebral spine. The aim of this review is to screen the literature dealing with acute traumatic thoracic vertebral fractures in patients with normal bone quality. Thereby, the diagnostic of thoracic vertebral body fractures should include a CT examination. Ideally, the CT should include the whole thoracic cage particularly in patients suffering high energy accidents or in those with clinical suspicion of concomitant thoracic injuries. Generally, concomitant thoracic injuries are frequently seen in patients with thoracic spine fractures. Particularly sternal fractures cause an increase in fracture instability. In case of doubt, long segment stabilization is recommended in patients with unstable mid- und upper thoracic fractures, particularly in those patients with a high grade of instability. Zusammenfassung Die meisten Publikationen, die sich mit nicht zervikalen Wirbelkörperfrakturen befassen, schließen die gesamte thorakolumbale Wirbelsäule ein und erfassen dabei hauptsächlich Frakturen des thorakolumbalen Übergangs und der Lendenwirbelsäule, sodass Frakturen der mittleren und oberen Brustwirbelsäule unterpräsentiert sind. Dagegen unterscheidet sich die Biomechanik der Brustwirbelsäule erheblich von der des thorakolumbalen Übergangs und der Lendenwirbelsäule. Dieses Review befasst sich mit der Literatur, die sich isoliert mit traumatischen Frakturen der Brustwirbelsäule beschäftigt. Dabei zeigt sich, dass die Diagnostik eine CT einschließlich der umgebenden Strukturen beinhalten sollte, da Begleitverletzungen am Thorax sehr häufig sind. Insbesondere zusätzliche Sternumfrakturen erhöhen den Grad der Instabilität. Der Goldstandard der Versorgung sollte insbesondere bei Frakturen mit hohem Grad an Instabilität die langstreckige dorsale Stabilisierung sein.
Effects of High Pressure and Sodium Nitrite Levels on Cured Color Development and Residual Nitrite Concentration in Pork Homogenates

This study investigated the effects of high pressure with or without thermal treatment on the cured color development andresidual nitrite contents of model meat systems (pork, NaCl and sodium nitrite). At low nitrite levels (≤50 µg/g), 200 MPaof pressure alone (P) did not develop the cured meat color (p>0.05). Thermal treatment (T) showed curing pigmentation(higher CIE L* and CIE a*), and the impacts were more effective when pressure was combined with thermal treatment (PT). In contrast, nitrite levels did not contribute to the cured meat color when ≥200 µg/g of nitrite was added to the meat. At highnitrite levels, although the typical cured color that is induced by thermal treatment did not present by pressure alone, the PTtreatment still showed a pinker color with low residual nitrite content compared to the T treatment. The higher the pressurelevel (300 MPa), the greater the cured meat pigmentation with lower residual nitrite. Therefore, the present studydemonstrates the possible application of high pressure, both for cured pigmentation and reducing residual nitrite, respectiveto typical thermal treatments.Key words: pressure, reducing activity, cured pigment, residual nitrite, oxidation
Ethics and governance for digital disease surveillance

The question is not whether to use new data sources but how Digital epidemiology—the use of data generated outside the public health system for disease surveillance—has been in use for more than a quarter century [see supplementary materials (SM)]. But several countries have taken digital epidemiology to the next level in responding to COVID-19. Focusing on core public health functions of case detection, contact tracing, and isolation and quarantine, we explore ethical concerns raised by digital technologies and new data sources in public health surveillance during epidemics. For example, some have voiced concern that trust and participation in such approaches may be unevenly distributed across society; others have raised privacy concerns. Yet counterbalancing such concerns is the argument that “sometimes it is unethical not to use available data” (1); some trade-offs may be not only ethically justifiable but ethically obligatory. The question is not whether to use new data sources—such as cellphones, wearables, video surveillance, social media, internet searches and news, and crowd-sourced symptom self-reports—but how.
Myofunctional Trainer versus Twin Block in Developing Class II Division I Malocclusion: A Randomized Comparative Clinical Trial

This study aimed to evaluate and compare the dentoalveolar effects of the myofunctional trainer T4KTM versus twin block in children with class II division I malocclusion. Two parallel arm randomized comparative clinical trial was conducted, including twenty healthy children, 9–12 years old, showing Angle’s class II division I malocclusion due to mandibular retrusion. Children were randomly assigned into two groups according to the appliance used; Group 1: T4k, and Group II: twin block. Follow-up was done every 4 weeks for 9 months. Postoperative cephalometric X ray, study casts and photographs were taken for measurements and comparison. T4K showed a statistically significant reduction in the overjet (−2.50 ± 1.00 mm) (p < 0.0001), and a significant increase in the lower arch perimeter (LAP) (1.19 ± 0.96 mm) (p = 0.01). The twin block showed a statistically significant reduction in the overjet (−3.75 ± 1.10 mm) (p < 0.0001), a significant reduction in the overbite (−16.22 ± 17.02 %) (p = 0.03), and a significant increase in the LAP (1.69 ± 0.70 mm) (p < 0.0001). The overjet showed a higher significant decrease in the twin block group than in T4K (p = 0.03). The mean values of the overbite were significantly decreased in twin block than in T4k (p < 0.0001). Both groups showed significant dentoalveolar improvements toward class I occlusion; however, the twin block showed significantly better results than T4K appliance.
Coronavirus Disease 2019 and the Cerebrovascular‐Cardiovascular Systems: What Do We Know So Far?

Abstract The severe acute respiratory syndrome coronavirus 2 pandemic of 2019 to 2020 has resulted in multiple hospitalizations, deaths, and economic hardships worldwide. Although respiratory involvement in patients with coronavirus disease 2019 (COVID‐19) is well known, the potential cardiovascular and cerebrovascular manifestations are less understood. We performed a PubMed and Google Scholar search and reviewed relevant literature on COVID‐19 and cardiovascular system involvement. Severe acute respiratory syndrome coronavirus 2 possesses high affinity for angiotensin‐converting enzyme 2 receptor, which is highly concentrated in the lungs and cardiovascular tissue, thereby provoking concern for cardiovascular involvement in COVID‐19 cases. Preexisting cardiovascular and cerebrovascular disease has been shown in previous reports to be a risk factor for severe infection. On the basis of our review of published studies, COVID‐19 patients may be more likely to experience acute cardiac injury, arrhythmia, coagulation defects, and acute stroke and are likely to have poorer outcomes as a result. As the COVID‐19 pandemic continues, more data about potential cardiovascular and cerebrovascular manifestations of the disease are required.
Microbeam X-ray diffraction study of lipid structure in stratum corneum of human skin

Human skin, not previously frozen, was studied by small-angle X-ray diffraction. The samples were folded so that a 6μm X-ray beam passed through the top layer of skin, stratum corneum. Diffraction patterns recorded with this method consisted of peaks at about q = 0.5, 1.0 and 1.4 nm-1 in the direction perpendicular to the skin surface more clearly than in previous studies. These peaks are interpreted to arise from lipids between corneocytes. A simple unit of a linear electron density profile with three minima was used to account for the observed intensity profiles. Combinations of calculated diffraction from models with one, two and three units accounted for the major part of the observed diffraction pattern, showing the diversity in the structure of the intercellular lipids.
Sex‐Specific Differences in Life Span Brain Volumes in Multiple Sclerosis

Numerous sex‐specific differences in multiple sclerosis (MS) susceptibility, disease manifestation, disability progression, inflammation, and neurodegeneration have been previously reported. Previous magnetic resonance imaging (MRI) studies have shown structural differences between female and male MS brain volumes. To determine sex‐specific global and tissue‐specific brain volume throughout the MS life span in a real‐world large MRI database.
4f-Metal Clusters Exhibiting Slow Relaxation of Magnetization: A {Dy7} Complex with An Hourglass-like Metal Topology

The reaction between Dy(NO3)3∙6H2O and the bulky Schiff base ligand, N-naphthalidene-2-amino-5-chlorobenzoic acid (nacbH2), in the presence of the organic base NEt3 has led to crystallization and structural, spectroscopic and magnetic characterization of a new heptanuclear [Dy7(OH)6(OMe)2(NO3)1.5(nacb)2(nacbH)6(MeOH)(H2O)2](NO3)1.5 (1) compound in ~40% yield. Complex 1 has a unique hourglass-like metal topology, among all previously reported {Dy7} clusters, comprising two distorted {Dy4(μ3-OH)3(μ3-OMe)}8+ cubanes that share a common metal vertex (Dy2). Peripheral ligation about the metal core is provided by the carboxylate groups of four η1:η1:η1:μ single-deprotonated nacbH− and two η1:η1:η2:η1:μ3 fully-deprotonated nacb2− ligands. Complex 1 is the first structurally characterized 4f-metal complex bearing the chelating/bridging ligand nacbH2 at any protonation level. Magnetic susceptibility studies revealed that 1 exhibits slow relaxation of magnetization at a zero external dc field, albeit with a small energy barrier of ~5 K for the magnetization reversal, most likely due to the very fast quantum-tunneling process. The combined results are a promising start to further explore the reactivity of nacbH2 upon all lanthanide ions and the systematic use of this chelate ligand as a route to new 4f-metal cluster compounds with beautiful structures and interesting magnetic dynamics.
The role of gender disparities in kidney injury

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Center for Kidney Disease, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Veterans Affairs, Nashville, TN, USA Correspondence to: Dr. Raymond C. Harris. C-3321 Medical Center North, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Email: ray.harris@vanderbilt.edu. Provenance and Peer Review: This article is commissioned and reviewed by the Section Editor Dr. Cheng Yuan, MD, PhD (Zhongnan Hospital, Wuhan University, Wuhan, China). Comment on: Ricardo AC, Yang W, Sha D, et al. Sex-Related Disparities in CKD Progression. J Am Soc Nephrol 2019;30:137-46.
UVR8-mediated inhibition of shade avoidance involves HFR1 stabilization in Arabidopsis

Sun-loving plants perceive the proximity of potential light-competing neighboring plants as a reduction in the red:far-red ratio (R:FR), which elicits a suite of responses called the "shade avoidance syndrome" (SAS). Changes in R:FR are primarily perceived by phytochrome B (phyB), whereas UV-B perceived by UV RESISTANCE LOCUS 8 (UVR8) elicits opposing responses to provide a counterbalance to SAS, including reduced shade-induced hypocotyl and petiole elongation. Here we show at the genome-wide level that UVR8 broadly suppresses shade-induced gene expression. A subset of this gene regulation is dependent on the UVR8-stabilized atypical bHLH transcription regulator LONG HYPOCOTYL IN FAR-RED 1 (HFR1), which functions in part redundantly with PHYTOCHROME INTERACTING FACTOR 3-LIKE 1 (PIL1). In parallel, UVR8 signaling decreases protein levels of the key positive regulators of SAS, namely the bHLH transcription factors PHYTOCHROME INTERACTING FACTOR 4 (PIF4) and PIF5, in a COP1-dependent but HFR1-independent manner. We propose that UV-B antagonizes SAS via two mechanisms: degradation of PIF4 and PIF5, and HFR1- and PIL1-mediated inhibition of PIF4 and PIF5 function. This work highlights the importance of typical and atypical bHLH transcription regulators for the integration of light signals from different photoreceptors and provides further mechanistic insight into the crosstalk of UVR8 signaling and SAS.
COVID‐19: The immediate response of european academic dental institutions and future implications for dental education

Abstract The COVID‐19 pandemic has had an immediate and dramatic impact on dental education. The Association of Dental Education in Europe decided to carry out an investigation to assess the immediate response of European Academic Dental Institutions. An online survey was sent to both member and non‐member dental schools to investigate the impact on non‐clinical and clinical education, assessment and the well‐being/pastoral care measures implemented. The preliminary findings and discussion are presented in this paper, for the responses collected between the 25 March and 5 April 2020. The survey at this time of publication is ongoing, and detailed results can be accessed https://adee.org/covid‐19‐european‐dental‐education%E2%80%99s‐immediate‐response.
Cellular Environment Remodels the Genomic Fabrics of Functional Pathways in Astrocytes

We profiled the transcriptomes of primary mouse cortical astrocytes cultured alone or co-cultured with immortalized precursor oligodendrocytes (Oli-neu cells). Filters between the cell types prevented formation of hetero-cellular gap junction channels but allowed for free exchange of the two culture media. We previously reported that major functional pathways in the Oli-neu cells are remodeled by the proximity of non-touching astrocytes and that astrocytes and oligodendrocytes form a panglial transcriptomic syncytium in the brain. Here, we present evidence that the astrocyte transcriptome likewise changes significantly in the proximity of non-touching Oli-neu cells. Our results indicate that the cellular environment strongly modulates the transcriptome of each cell type and that integration in a heterocellular tissue changes not only the expression profile but also the expression control and networking of the genes in each cell phenotype. The significant decrease of the overall transcription control suggests that in the co-culture astrocytes are closer to their normal conditions from the brain. The Oli-neu secretome regulates astrocyte genes known to modulate neuronal synaptic transmission and remodels calcium, chemokine, NOD-like receptor, PI3K-Akt, and thyroid hormone signaling, as well as actin-cytoskeleton, autophagy, cell cycle, and circadian rhythm pathways. Moreover, the co-culture significantly changes the gene hierarchy in the astrocytes.
Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence

Heart failure (HF) is a growing health concern in aging societies worldwide. Sacubitril/valsartan is changing the real-world treatment in the whole spectrum of HF. The beginning was the PARADIGM-HF trial published in 2014, which demonstrated the beneficial effects of inhibiting natriuretic peptide breakdown in combination with hindering the renin-angiotensin system in HF patients with a reduced ejection fraction. Subsequent large-scale randomized trials have evaluated angiotensin receptor-neprilysin inhibitor in HF patients with acute decompensation or with preserved ejection fraction. The post hoc analyses are being conducted as well. This review summarizes the recent evidence of sacubitril/ valsartan regarding patient-centered outcomes, based on randomized controlled trials and their associated studies.
Comparative Analysis of Root Transcriptome Reveals Candidate Genes and Expression Divergence of Homoeologous Genes in Response to Water Stress in Wheat

Crop cultivars with larger root systems have an increased ability to absorb water and nutrients under conditions of water deficit. To unravel the molecular mechanism of water-stress tolerance in wheat, we performed RNA-seq analysis on the two genotypes, Colotana 296-52 (Colotana) and Tincurrin, contrasting the root growth under polyethylene-glycol-induced water-stress treatment. Out of a total of 35,047 differentially expressed genes, 3692 were specifically upregulated in drought-tolerant Colotana under water stress. Transcription factors, pyrroline-5-carboxylate reductase and late-embryogenesis-abundant proteins were among upregulated genes in Colotana. Variant calling between Colotana and Tincurrin detected 15,207 SNPs and Indels, which may affect protein function and mediate the contrasting root length phenotype. Finally, the expression patterns of five triads in response to water, high-salinity, heat, and cold stresses were analyzed using qRT-PCR to see if there were differences in homoeologous gene expression in response to those conditions. The five examined triads showed variation in the contribution of homoeologous genes to water, high-salinity, heat, and cold stresses in the two genotypes. The variation of homoeologous gene expression in response to environmental stresses may enable plants to better cope with stresses in their natural environments.
Dog-assisted interventions and outcomes for older adults in residential long-term care facilities: A systematic review and meta-analysis.

OBJECTIVE To comprehensively review studies on dog-assisted interventions (DAIs) among older people in residential long-term care facilities (RLTCFs) and to provide an overview of their interventions, outcomes and methodological quality. METHOD We searched 18 electronic databases to identify English articles (published January 2000-December 2019) reporting on well-defined DAIs targeting older adults (≥65 years) in RLTCF. Data were extracted by two independent reviewers. Descriptive statistics were produced for quantitative studies, with key themes identified among qualitative studies. Where possible, estimates were pooled from randomised controlled trials using random effects meta-analyses. RESULTS Forty-three relevant studies (39 quantitative; 4 qualitative) were identified. The majority of quantitative studies were assessed as low-quality according to the MMAT criteria (n = 26, 67%). Almost half of the quantitative studies (n = 18, 46%) found no significant changes over time or between groups across outcomes measured. The most salient intervention effects included improved social functioning (n = 10), reduced depressive symptoms (n = 6) and loneliness (n = 5). A random-effects meta-analysis revealed a medium effect in favour of DAT on reducing depressive or loneliness symptoms (pooled SMD: 0.66, 95%CI 0.21-1.11; I2 = 50.5; five trials), relative to treatment as usual. However, compared to treatment as usual, no overall effect of DAI on activities of daily living was detected (p = .737). Key themes from qualitative studies included (a) animals as effective transitional objects, (b) the therapeutic value of pets and (c) the significance of the care environment and stakeholders in facilitating DAI. IMPLICATIONS FOR PRACTICE The findings of this review indicate that while DAI has value for older people in RLTCF, challenges remain in accurately measuring its impact to provide a stronger evidence-base. Standardisation of DAI service design, delivery and evaluation is required for future research and practice in providing holistic care for older adults.
Discovery of DS-1971a, a Potent Selective NaV1.7 Inhibitor.

A highly potent, selective NaV1.7 inhibitor, DS-1971a has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the discovery of novel series of cycloalkane derivatives with high NaV1.7 inhibitory potency in vitro. As the right-hand heteroaromatic ring affected the mechanism-based inhibition liability of CYP3A4, replacement of this moiety resulted in the generation of 4-pyrimidyl derivatives. Additionally, GSH adducts formation, which can cause idiosyncratic drug toxicity, was successfully avoided by this modification. An additional optimization led to the discovery of DS-1971a. In preclinical studies, DS-1971a demonstrated highly potent selective in vitro profile with robust efficacy in vivo. DS-1971a exhibited a favorable toxicological profile, which enabled multiple-dose studies of up to 600 mg bid or 400 mg tid (1200 mg/day) administered for 14 days to healthy human males. DS-1971a is expected to exert potent efficacy in patients with peripheral neuropathic pain, with a favorable safety profile.
Long‐term retention of self‐recognition by chimpanzees

Two young chimpanzees showed retention of self‐recognition after 1 year without access to mirrors. A year earlier the animals were positive on the Gallup dye test. One year later they were once again anesthetized, marked on the brow and ears, and following recovery, exposed individually to a large mirror. Both demonstrated mirror‐orientated mark‐directed responses. Time‐sample observations of behavior toward the mirror further support self‐recognition. The chimpanzee's self‐awareness, as inferred from its self‐recognition, appears to be a stable characteristic of the animal.