Miracle-dz/UniFAR-FTUs huggingface dataset:
Convergence Theorems for Two Asymptotically Nonexpansive Non-self Mappings in Uniformly Convex Banach Spaces

Let K be a nonempty closed convex non expansive retract of a uniformly convex Banach space E with P as a non expansive retraction. Let T 1 , T 2 : K → E be two asymptotically non expansive non-self mappings with sequences {k n }, {h n } ⊂[1,(∞) such that Σ ∞ n=1 (k n h n -1) < ∞ and F = F(T 1 ) ∩ F(T 2 ) = {x E K : T 1 x = T 2 x = x}≠ Φ . Let {x n } ∞ n=1 be the sequence generated iteratively by x l ∈ K and x n+1 = P(a n x n + b n T 1 (PT 1 ) n-1 y n + c n l n ) ∀ n ≥1 y n = P(ā n x n + b n T n (PT 2 ) n-1 x n + c n m n ),∀ n ≥1 where {l n }, {m n } are bounded sequences, a n +b n +c n = 1 = ā n +b n +c n ,0 ≤ a n +b n +c n , ā n +b n +c n ≤ 1, ∀ n ∈ N, Σ ∞ n=1 c n < ∞ and Σ ∞ n=1 b n c n <∞ . If T 1 is completely continuous or T 1 and T 2 satisfy condition (A'), then {x n } converges strongly to a point in F = F(T 1 ) ∩ F(T 2 ). Also if E satisfies Opial's condition or the dual E* of E has the Kedec-Klee property, then {x n } converges weakly to a point in F.
Comparison at the sub-100 fW optical power level of calibrating a single-photon detector using a high-sensitive, low-noise silicon photodiode and the double attenuator technique

A comparison down to sub-100-fW optical power level was carried out between a low-noise Silicon photodiode and a low optical flux measurement facility based on a double attenuator technique. The comparison was carried out via a silicon single-photon avalanche diode (Si-SPAD), which acted as transfer standard. The measurements were performed at a wavelength of 770 nm using an attenuated laser as a radiation source at optical power levels between approximately 86 fW and approximately 1325 fW, corresponding to approximately 330 000 photons s−1 and approximately 5.2 × 106 photons s−1, respectively. The mean relative deviation of the detection efficiencies of the Si-SPAD, determined by the Si-photodiode and the low optical flux measurement facility, i.e. between two completely independent traceability routes, was < 0.2%, thus well within the combined standard uncertainty of the two measurements. To our knowledge, this is the first comparison for the detection efficiency of a single photon detector using a direct optical flux measurement by a conventional Si-photodiode at such low power levels.
First orbital elements for the lambda Bootis spectroscopic binary systems HD 84948 and HD 171948. Implications for the origin of the lambda Bootis stars

We present high-resolution spectroscopic observations of the two Bootis type spectroscopic binary systems HD 84948 and HD 171948. Both systems consist of two true Bootis stars, as has already been proven by a detailed abundance analysis taking into account the binary nature. Nevertheless, we have obtained non- LTE abundances for carbon and oxygen in order to investigate those important elements. The abundances t excellently into the typical pattern for this group, leaving no doubt that all four components are true Bootis stars. With the help of the derived orbital elements it is possible to establish the ages of the two systems. For the rst time we can estimate the evolutionary status of Galactic eld Bootis stars. The origin of those nonmagnetic, metal-weak, Population I, late B- to early F-type stars is still controversial. The two widely discussed theories explaining the Bootis phenomenon (diusion together with either accretion of circumstellar matter or mass- loss) predict signicantly dierent evolutionary stages for this group of objects (close to either the Zero-Age Main Sequence or Terminal-Age Main Sequence). It is already known that very young members of the group exist in the Orion OBI association and probably in NGC 2264. Hipparcos data established six further Galactic eld Bootis stars which are close to the Zero-Age Main Sequence, whereas the evolutionary status for the other objects remained undetermined. The Hipparcos data reveal that the Galactic space motions of both the systems that we discuss here are typical of those of Population I objects. The photometric data from the Hipparcos mission conrm the pulsation previously discovered for HD 84948 with a period of about 110 min and a V -amplitude of about 14 mmag. For HD 84948, we estimate from the mass ratio an age of about 1 Gyr, ruling out a possible Pre-Main-Sequence status. HD 171948 has an age of about 0.01 to 0.1 Gyr which is close to the Zero-Age Main Sequence. We therefore conclude that the Bootis phenomenon can be found continuously from very early stages to the Terminal-Age Main Sequence, suggesting that dierent mechanisms might work at dierent stages of stellar evolution producing the same abundance pattern.
Koopman-inspired approach for identification of exogenous anomalies in nonstationary time-series data

In many scenarios, it is necessary to monitor a complex system via a time-series of observations and determine when anomalous exogenous events have occurred so that relevant actions can be taken. Determining whether current observations are abnormal is challenging. It requires learning an extrapolative probabilistic model of the dynamics from historical data, and using a limited number of current observations to make a classification. We leverage recent advances in long-term probabilistic forecasting, namely Deep Probabilistic Koopman, to build a general method for classifying anomalies in multi-dimensional time-series data. We also show how to utilize models with domain knowledge of the dynamics to reduce type I and type II error. We demonstrate our proposed method on the important real-world task of global atmospheric pollution monitoring, integrating it with NASA’s Global Earth Observing System Model. The system successfully detects localized anomalies in air quality due to events such as COVID-19 lockdowns and wildfires.
Laser-induced fluorescence measurements of spatially resolved OH densities in a helium plasma jet interacting with three different targets in the open air

The presented research work is devoted to the measurements of the absolute densities of ground state OH radicals in an atmospheric pressure helium plasma jet launched in free air onto three different targets. The OH density is measured by using laser induced fluorescence (LIF). The plasma is generated inside a glass tube by a dielectric barrier discharge powered by a mono-polar pulsed high voltage. Estimation of the absolute density is based on a quantitative analysis of the spectral and temporal component of the LIF signal and does not require any assumption on the densities of colliding species. Based on this analysis, the spatially-resolved density distributions of OH radicals are determined in front of three different targets (metallic, dielectric, and ultra-pure water) placed in the open air at 2 cm from the exit of the glass tube. In order to also investigate the temporal behaviour of the OH densities, and the influence of the gas flow rate and of the amplitude of the voltage-pulse, planar LIF has been performed investigating the fluorescence signal (i) during the intervals of the discharge pulses, (ii) for various gas flow rates, and (iii) as a function of the amplitude of the voltage pulse. In the free jet configuration without a target, the OH densities were determined to be in the order of 1019m−3 , whereas they increased up to a factor of 10 in contact with a target. The spatial distributions were also influenced by the dielectric properties of the target: in the case of the metallic target, the maximum of the OH density was found to be in the center between the exit of the glass tube and the target, whereas in the case of the dielectric target, the maximum was found to be close to the surface of the target. In the case of ultra-pure water, the densities were equally distributed between the exit of the glass tube and the target. With this work, the influence of a target on the production of OH radicals was demonstrated, which enables the optimisation of the plasma parameters for an efficient production of OH radicals in front of a target with various dielectric properties.
A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass

There remains much that we do not understand about the earliest stages of human development. On a gross level, there is evidence for apoptosis, but the nature of the affected cell types is unknown. Perhaps most importantly, the inner cell mass (ICM), from which the foetus is derived and hence of interest in reproductive health and regenerative medicine, has proven hard to define. Here, we provide a multi-method analysis of the early human embryo to resolve these issues. Single-cell analysis (on multiple independent datasets), supported by embryo visualisation, uncovers a common previously uncharacterised class of cells lacking commitment markers that segregates after embryonic gene activation (EGA) and shortly after undergo apoptosis. The discovery of this cell type allows us to clearly define their viable ontogenetic sisters, these being the cells of the ICM. While ICM is characterised by the activity of an Old non-transposing endogenous retrovirus (HERVH) that acts to suppress Young transposable elements, the new cell type, by contrast, expresses transpositionally competent Young elements and DNA-damage response genes. As the Young elements are RetroElements and the cells are excluded from the developmental process, we dub these REject cells. With these and ICM being characterised by differential mobile element activities, the human embryo may be a “selection arena” in which one group of cells selectively die, while other less damaged cells persist.
Hepatic benefits of sodium-glucose cotransporter 2 inhibitors in liver disorders

Diabetic patients are at higher risk of liver dysfunction compared with the normal population. Thus, using hypoglycemic agents to improve liver efficiency is important in these patients. Sodium-glucose cotransporters-2 inhibitors (SGLT2i) are newly developed antidiabetic drugs with potent glucose-lowering effects. However, recent limited evidence suggests that they have extra-glycemic benefits and may be able to exert protective effects on the liver. Hence, these drugs could serve as promising pharmacological agents with multiple benefits against different hepatic disorders. In this review, the current knowledge about the possible effects of SGLT2 inhibitors on different forms of liver complications and possible underlying mechanisms are discussed.
Datumetine Preferentially Upregulates N-methyl-D-aspartate Receptor Signalling Pathways in Different Brain Regions of Mice

Introduction: We previously reported that datumetine possesses binding affinity with N-methyl-D-aspartate receptor (NMDAR) and that 14-day exposure to datumetine altered NMDAR signaling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice. Methods: 30 male adult BALB/c mice were used for the study. The mice were randomly divided into three groups of ten mice each with an intraperitoneal injection of 0.1 mL of 10% DMSO for the Vehicle group, Datumetine group were administered 0.1 mg/kg body weight (bw) of datumetine and MK-801+Datumetine group were administered 0.5 mg/kg bw of MK-801 (to block NMDAR) followed by 0.1 mg/kg bw of datumetine after 30 minutes. 24 hours after administration, mice were euthanized in an isoflurane chamber followed by perfusion with 1X PBS. Brains were excised and stored at −20°C till further processing. Mice designated for IHC were further perfused with 4% PFA and brain excised and stored in 4% PFA till further processing. NMDAR signalling molecules expression was evaluated in frozen brain samples and the fixed brain samples were stained for neuron, vGlut and NMDAR subtypes. Results: Relative to vehicle (Veh), datumetine downregulate calcium calmodulin kinase II alpha (CamKIIα) expression in the hippocampus and prefrontal cortex (PFC) but not in the cerebellum, cyclic AMP response element binding protein (CREB) was also upregulated only in the PFC but phosphorylated CREB (pCREB) was also upregulated in three brain regions observed, while brain-derived neurotrophic factor (BDNF) was only upregulated in hippocampus and PFC of Datumetine relative to vehicle (Veh). On the other hand, dizocilpine (MK-801) reversed some of the effects of datumetine in the observed brain regions. No major histological alterations were observed in the different brain regions immunohistochemically. Conclusion: We conclude that a low dose of datumetine moderately enhances NMDAR activity. This showed the neuroprotective potentials of low datumetine exposure.
TbsNet: the importance of thin-branch structures in CNNs

The performance of a convolutional neural network (CNN) model is influenced by several factors, such as depth, width, network structure, size of the receptive field, and feature map scaling. The optimization of the best combination of these factors poses as the main difficulty in designing a viable architecture. This article presents an analysis of key factors influencing network performance, offers several strategies for constructing an efficient convolutional network, and introduces a novel architecture named TbsNet (thin-branch structure network). In order to minimize computation costs and feature redundancy, lightweight operators such as asymmetric convolution, pointwise convolution, depthwise convolution, and group convolution are implemented to further reduce the network’s weight. Unlike previous studies, the TbsNet architecture design rejects the reparameterization method and adopts a plain, simplified structure which eliminates extraneous branches. We conduct extensive experiments, including network depth, width, etc. TbsNet performs well on benchmark platforms, Top 1 Accuracy on CIFAR-10 is 97.02%, on CIFAR-100 is 83.56%, and on ImageNet-1K is 86.17%. Tbs-UNet’s DSC on the Synapse dataset is 78.39%, higher than TransUNet’s 0.91%. TbsNet can be competent for some downstream tasks in computer vision, such as medical image segmentation, and thus is competitive with prior state-of-the-art deep networks such as ResNet, ResNeXt, RepVgg, ParNet, ConvNeXt, and MobileNet.
New records of the squat lobster genus Munidopsis Whiteaves, 1874 (Crustacea, Decapoda, Munidopsidae) from the deep sea off Taiwan

﻿Abstract Two species of the squat lobster family Munidopsidae, Munidopsisalbatrossae Pequegnat & Pequegnat, 1973 and M.pycnopoda Baba, 2005, are reported from Taiwan for the first time based on specimens collected from lower bathyal depths. The Taiwanese material of M.pycnopoda also represents the first record of the species from the Pacific Ocean and greatly extends this species’ geographical range from the western Indian Ocean to western Pacific. The giant Munidopsis specimen from Taiwan is identified as M.albatrossae mainly by DNA barcoding even though M.albatrossae and M.aries (A. Milne-Edwards, 1880) are both morphologically and genetically extremely similar.
Robust optimization in spline regression models for multi-model regulatory networks under polyhedral uncertainty

Abstract In our study, we integrate the data uncertainty of real-world models into our regulatory systems and robustify them. We newly introduce and analyse robust time-discrete target–environment regulatory systems under polyhedral uncertainty through robust optimization. Robust optimization has reached a great importance as a modelling framework for immunizing against parametric uncertainties and the integration of uncertain data is of considerable importance for the model’s reliability of a highly interconnected system. Then, we present a numerical example to demonstrate the efficiency of our new robust regression method for regulatory networks. The results indicate that our approach can successfully approximate the target–environment interaction, based on the expression values of all targets and environmental factors.
Efficacy of Vestibular Rehabilitation in Vestibular Neuritis

Objective This study aimed to evaluate the efficacy of vestibular rehabilitation in vestibular neuritis. Design A randomized controlled trial was collected from MEDLINE, Embase, Cochrane Library, PEDro, LILACS, and Google Scholar before May 2023. Results This study included 12 randomized controlled trials involving 536 patients with vestibular neuritis. Vestibular rehabilitation was comparable with steroids in dizziness handicap inventory score at the first, sixth, and 12th months (pooled mean differences: −4.00, −0.21, and −0.31, respectively); caloric lateralization at the third, sixth, and 12th months (pooled mean difference: 1.10, 4.76, and −0.31, respectively); and abnormal numbers of vestibular-evoked myogenic potentials at the first, sixth, and 12th months. Patients receiving a combination of rehabilitation and steroid exhibited significant improvement in dizziness handicap inventory score at the first, third, and 12th months (mean difference: −14.86, pooled mean difference: −4.63, mean difference: −9.50, respectively); caloric lateralization at the first and third months (pooled mean difference: −10.28, pooled mean difference: −8.12, respectively); and numbers of vestibular-evoked myogenic potentials at the first and third months (risk ratios: 0.66 and 0.60, respectively) than did those receiving steroids alone. Conclusions Vestibular rehabilitation is recommended for patients with vestibular neuritis. A combination of vestibular rehabilitation and steroids is more effective than steroids alone in the treatment of patients with vestibular neuritis.
Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution

Abstract [Purpose] Transarterial radioembolization (TARE) is an established treatment modality for patients with unresectable liver cancer. However, a better understanding of treatment parameters that influence microsphere distribution could further improve the therapy. This systematic review examines and summarizes the available evidence on intraprocedural parameters that influence the microsphere distribution during TARE as investigated by in vivo, ex vivo, in vitro and in silico studies. [Methods] A standardized search was performed in Medline, Embase and Web of Science to identify all published articles investigating microsphere distribution or dynamics during TARE. Studies presenting original research on parameters influencing the microsphere distribution during TARE were included. [Results] A total of 42 studies reporting a total of 11 different parameters were included for narrative analysis. The investigated studies suggest that flow distribution is not a perfect predictor of microsphere distribution. Increasing the injection velocity may help increase the similarity between flow and microsphere distributions. Furthermore, the microsphere distributions are very sensitive to the radial and axial catheter position. [Conclusion] The most promising parameters for future research which can be controlled in the clinic appear to be microsphere injection velocity as well as the axial catheter position. Up to now, many of the included studies do not take clinical feasibility into account, limiting the translation of results to clinical settings. Future research should therefore focus on the applicability of in vivo, in vitro, or in silico research to patient specific scenarios to improve the efficacy of radioembolization as treatment for liver cancer.
The importance of cryptic diversity in the conservation of wide‐ranging species: The red‐footed tortoise Chelonoidis carbonarius in Colombia

Wide‐ranging species are seldom considered conservation priorities, yet they have the potential to harbour genetically deeply differentiated units across environments or ecological barriers, including some that warrant taxonomic recognition. Documenting such cryptic genetic diversity is especially important for wide‐ranging species that are in decline, as they may comprise a set of even more endangered lineages or species with small distributions. However, studies of wide‐ranging species, particularly when they cross political borders, are extremely challenging. One approach to overcoming these challenges is to conduct detailed local analyses in combination with less detailed, range‐wide studies. We used this approach with the red‐footed tortoise (Chelonoidis carbonarius), a threatened species likely to contain cryptic diversity given its vast range and the distinctive ecoregions that it inhabits. Previous single‐gene molecular studies indicated the presence of at least five lineages, two of which occur in different ecoregions separated by the Andes within Colombia. We used a comprehensive genomic analysis to test the hypothesis of cryptic diversity within the single jurisdiction of Colombia. We used a combination of restriction‐site‐associated DNA sequencing and environmental niche modelling to provide three independent lines of evidence that support the presence of important cryptic diversity that may deserve taxonomic recognition: allopatric reproductive isolation, local adaptation and ecological divergence. We also provide a fine‐scale genetic map with the distribution of conservation units in Colombia. As we complete ongoing range‐wide analyses and make taxonomic adjustments, we recommend that the two lineages in Colombia be treated as separate units for conservation purposes.
Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models

The liver can fully regenerate after partial resection, and its underlying mechanisms have been extensively studied. The liver can also rapidly regenerate after injury, with most studies focusing on hepatocyte proliferation; however, how hepatic necrotic lesions during acute or chronic liver diseases are eliminated and repaired remains obscure. Here, we demonstrate that monocyte-derived macrophages (MoMFs) were rapidly recruited to and encapsulated necrotic areas during immune-mediated liver injury and that this feature was essential in repairing necrotic lesions. At the early stage of injury, infiltrating MoMFs activated the Jagged1/notch homolog protein 2 (JAG1/NOTCH2) axis to induce cell death–resistant SRY-box transcription factor 9+ (SOX9+) hepatocytes near the necrotic lesions, which acted as a barrier from further injury. Subsequently, necrotic environment (hypoxia and dead cells) induced a cluster of complement 1q–positive (C1q+) MoMFs that promoted necrotic removal and liver repair, while Pdgfb+ MoMFs activated hepatic stellate cells (HSCs) to express α–smooth muscle actin and induce a strong contraction signal (YAP, pMLC) to squeeze and finally eliminate the necrotic lesions. In conclusion, MoMFs play a key role in repairing the necrotic lesions, not only by removing necrotic tissues, but also by inducing cell death–resistant hepatocytes to form a perinecrotic capsule and by activating α-smooth muscle actin–expressing HSCs to facilitate necrotic lesion resolution.