Miracle-dz/UniFAR-FTUs huggingface dataset:
Misère Games and Misère Quotients Version 1 . 0

These notes are based on a short course offered at the Weizmann Institute of Science in Rehovot, Israel, in November 2006. The notes include an introduction to impartial games, starting from the beginning; the basic misère quotient construction; a proof of the Guy–Smith–Plambeck Periodicity Theorem; and statements of some recent results and open problems in the subject. First and foremost, I wish to thank the scribes for the course: Gideon Amir, Shiri Chechik, Omer Kadmiel, Amir Kantor, Dan Kushnir, Shai Lubliner, Ohad Manor, Leah Nutman, Menachem Rosenfeld, and Rivka Taub. I also wish to thank Professor Aviezri Fraenkel for inviting me to the Weizmann Institute and suggesting this course, and thereby making these notes possible. Finally, I wish to thank Thane Plambeck, for recognizing the importance of misère quotients and inventing this beautiful and fascinating theory.
Q A ] 3 J an 2 00 0 SOLUTIONS OF THE KZB EQUATIONS IN GENUS GREATER THAN

Introduction. The Knizhnik-Zamolodchikov-Bernard connection ([23, 5, 28]) can be viewed as a flat connection over the complement det∗g,ν of the zero-section in the total space of the determinant line bundle over the moduli space Mg,ν·12 of genus g curves with ν marked points and tangent vectors ([4]). Projectivization of this connection is the pull-back of a flat projective connection on Mg,ν·12. The aim of this paper is two-fold. We first construct a flat version of the KZB connection over the moduli space Mg,ν·12, when ν ≥ 1 (we will set ν = n+1). We then give integral formulas for flat sections of this connection, using the functional parametrization of conformal blocks and the KZB connection introduced in [10].
Thermodynamics of adsorption onto single-walled carbon nanotube homogeneous bundles

The thermodynamics of adsorption onto multi-site adsorptive solids has been studied employing different probe molecules (CH 4 , C 2 H 6 , C 2 H 4 , C 3 H 8 , C 3 H 6 ), and conducting configurational- bias Grand Canonical Monte Carlo simulations. The phase space has been systematically accessed performing calculations at room temperature in the reduced pressure range 8.7 × 10 ‒ 9 < ( p / p 0 ) < 0.9. The solid consisted of homogeneous single-walled carbon nanotube bundles with an individual nanotube diameter distribution of 11.0 Å ≤ D ≤ 18.1 Å. The resulting picture is interpreted in terms of the molecular nature of the adsorbate and the corresponding solid-fluid interactions. Results obtained indicate that confinement onto the bundles interior volume (interstitial and intratubular) is energetically more favorable than physisorption onto the bundles exterior volume (grooves and rounded surface), as indicated by the isosteric heat curves, q st , as function of reduced pressure. Nonetheless, the zero-coverage properties suggest a crossover point to the former behavior, located at D ≈ 18 ‒ 19 Å. Moreover, when interstitial confinement is not inhibited by geometrical considerations, it was possible to establish a general relative order for the isosteric heat of adsorption : ( ) erstitial ratubular surface . I . I NTRODUCTION
State estimation with finite communication bandwidth constraints

Presents an overview of the results reported in Wong and Brockett in which a class of state estimation problems with finite communication capacity constraint is investigated. The concepts of a coder-estimator sequence and a finitely recursive coder-estimator sequence are introduced. Some concrete coder-estimator sequences are defined and their convergent properties analyzed.
Modeling toolchain for realistic simulation of photoacoustic data acquisition

Abstract Significance: Physics-based simulations of photoacoustic (PA) signals are used to validate new methods, to characterize PA setups and to generate training datasets for machine learning. However, a thoroughly validated PA simulation toolchain that can simulate realistic images is still lacking. Aim: A quantitative toolchain was developed to model PA image acquisition in complex tissues, by simulating both the optical fluence and the acoustic wave propagation. Approach: Sampling techniques were developed to decrease artifacts in acoustic simulations. The performance of the simulations was analyzed by measuring the point spread function (PSF) and using a rotatable three-channel phantom, filled with cholesterol, a human carotid plaque sample, and porcine blood. Ex vivo human plaque samples were simulated to validate the methods in more complex tissues. Results: The sampling techniques could enhance the quality of the simulated PA images effectively. The resolution and intensity of the PSF in the turbid medium matched the experimental data well. Overall, the appearance, signal-to-noise ratio and speckle of the images could be simulated accurately. Conclusions: A PA toolchain was developed and validated, and the results indicate a great potential of PA simulations in more complex and heterogeneous media.
A 3-D Random Breaking Model for Directional Spectral Waves

A 3-D Random Breaking Model for Directional Spectral Waves. A new directional wave deformation model due to random wave breaking is developed. The model combines the Kweon and Goda's breaking model (1996) for uni-directional wave and the Karlsson's energy balance equation (1969) with its numerical scheme for directional waves. The basic concept of the Kweon and Goda'a model is to let the wave decay factor vary gradually over a certain distance in order to take into account the random wave breaking process. This concept of gradually varying decay factor is employed as the key Parameter of the new model. However, the spreading of breaking and broken waves in a 3-D system of x, y, a is dealt with modification of the wave decay factor after breaking The modification process is calibrated by comparison with two existing models for uni-directional wave breaking. Verifications were made with two sets of experimental data involving 3-D wave breaking phenomena which were investigated by two laboratories, The model is found to be capable of predicting reasonably well the variations of significant wave heights over shoals measured at two laboratories. With an easiness in computation, the present model is promised to be a practitioner's tool in analyzing spectral wave deformation with breaking.
Correlation between higher-order aberration and photophobia after cataract surgery

Cataract surgery impinges on the spatial properties and wavelength distribution of retinal images, which changes the degree of light-induced visual discomfort/photophobia. However, no study has analyzed the alteration in photophobia before and after cataract surgery or the association between retinal spatial property and photophobia. Here, we measured the higher-order aberrations (HOAs) of the entire eye and the subjective photophobia score. This study investigated 71 eyes in 71 patients who received conventional cataract surgery. Scaling of photophobia was based on the following grading system: when the patient is outdoor on a sunny day, score of 0 and 10 points were assigned to the absence of photophobia and the presence of severe photophobia prevents eye-opening, respectively. We decomposed wavefront errors using Zernike polynomials for a 3-mm pupil diameter and analyzed the association between photophobia scores and HOAs with Spearman’s rank sum correlation (rs). We classified patients into two groups: photophobia (PP) unconcerned included patients who selected 0 both preoperatively or postoperatively and PP concerned included the remaining patients. After cataract surgery, photophobia scores increased, remained unchanged (stable), and decreased in 3, 41, and 27 cases, respectively. In the stable group, 35 of 41 cases belonged to PP unconcerned. In PP concerned, there were significant correlations between photophobia score and postoperative root-mean-square values of total HOAs (rs = 0.52, p = 0.002), total coma (rs = 0.52, p = 0.002), total trefoil (rs = 0.47, p = 0.006), and third-order group (rs = 0.53, p = 0.002). In contrast, there was no significant correlation between photophobia scores and preoperative HOAs. Our results suggest that the spatial properties of retinal image modified by HOAs may affect the degree of photophobia. Scattering light due to cataracts could contribute to photophobia more than HOAs, which may mask the effect of HOAs for photophobia preoperatively.
Comparison of time trends in the incidence of primary liver cancer between China and the United States: an age–period–cohort analysis of the Global Burden of Disease 2019

Abstract Background: China and the United States (US) ranked first and third in terms of new liver cancer cases and deaths globally in 2020. Therefore, a comprehensive assessment of trends in the incidence of primary liver cancer with four major etiological factors between China and the US during the past 30 years with age-period-cohort (APC) analyses is warranted. Methods: Data were obtained from the Global Burden of Disease 2019, and period/cohort relative risks were estimated by APC modeling from 1990 to 2019. Results: In 2019, there were 211,000 new liver cancer cases in China and 28,000 in the US, accounting for 39.4% and 5.2% of global liver cancer cases, respectively. For China, the age-standardized incidence rate (ASIR) consecutively decreased before 2005 but increased slightly since then, whereas the ASIR continuously increased in the US. Among the four etiological factors of liver cancer, the fastest reduction in incidence was observed in hepatitis B virus-related liver cancer among Chinese women, and the fastest increase was in nonalcoholic steatosis hepatitis (NASH)-related liver cancer among American men. The greatest reduction in the incidence of liver cancer was observed at the age of 53 years in Chinese men (−5.2%/year) and 33 years in Chinese women (−6.6%/year), while it peaked at 58 years old in both American men and women (4.5%/year vs. 2.8%/year). Furthermore, the period risks of alcohol- and NASH-related liver cancer among Chinese men have been elevated since 2013. Simultaneously, leveled- off period risks were observed in hepatitis C viral-related liver cancer in both American men and women. Conclusions: Currently, both viral and lifestyle factors have been and will continue to play an important role in the time trends of liver cancer in both countries. More tailored and efficient preventive strategies should be designed to target both viral and lifestyle factors to prevent and control liver cancer.
Association of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes

Background and Objectives Type 2 diabetes and lifestyle factors have been associated with dementia risk, but the effect of a healthy lifestyle on diabetes-related dementia remains largely unknown. We aimed to investigate whether the increased risk of dementia among individuals with diabetes can be offset by a broad combination of healthy lifestyle factors. Methods This prospective study used data from the UK Biobank cohort. An overall lifestyle score ranging from 0 to 7 was created, with 1 point for each of the 7 healthy lifestyle factors: no current smoking, moderate alcohol consumption, regular physical activity, healthy diet, adequate sleep duration, less sedentary behavior, and frequent social contact. Incident dementia was ascertained using linkage with electronic health records. Cox proportional hazards models were used to examine the associations between diabetes, healthy lifestyle score, and dementia incidence. Results We included 167,946 participants aged 60 years or older without dementia at baseline (mean age 64.1 [SD 2.8] years, 51.7% female). During a median follow-up of 12.3 years, 4,351 developed all-cause dementia. Participants with diabetes, but not those with prediabetes, showed a higher risk of dementia than those with normoglycemia. Compared with diabetes-free participants who had a lifestyle score of 7, the hazard ratios (HRs) for dementia were 4.01 (95% CI 3.06–5.25) and 1.74 (95% CI 1.11–2.72) for those with diabetes who had a lifestyle score of 0–2 and 7, respectively. Among participants with diabetes, the HR for dementia comparing a lifestyle score of 7 vs 0–2 was 0.46 (95% CI 0.28–0.75). This finding corresponded to a reduction in the 10-year absolute risk of dementia from 5.22% (95% CI 3.94%–6.73%) to 1.72% (95% CI 0.92%–2.97%). The association between higher lifestyle score and lower dementia risk was independent of glycemic control and diabetes medication. Discussion Adherence to a broad range of healthy lifestyle factors was associated with a significantly lower risk of dementia among participants with diabetes. Behavioral lifestyle modification through multifactorial approaches should be a priority for prevention and delayed onset of dementia in patients with diabetes.
Multi-dimensional sigma-functions

In 1997 the present authors published a review (Ref. BEL97 in the present manuscript) that recapitulated and developed classical theory of Abelian functions realized in terms of multi-dimensional sigma-functions. This approach originated by K.Weierstrass and F.Klein was aimed to extend to higher genera Weierstrass theory of elliptic functions based on the Weierstrass $\sigma$-functions. Our development was motivated by the recent achievements of mathematical physics and theory of integrable systems that were based of the results of classical theory of multi-dimensional theta functions. Both theta and sigma-functions are integer and quasi-periodic functions, but worth to remark the fundamental difference between them. While theta-function are defined in the terms of the Riemann period matrix, the sigma-function can be constructed by coefficients of polynomial defining the curve. Note that the relation between periods and coefficients of polynomials defining the curve is transcendental. Since the publication of our 1997-review a lot of new results in this area appeared (see below the list of Recent References), that promoted us to submit this draft to ArXiv without waiting publication a well-prepared book. We complemented the review by the list of articles that were published after 1997 year to develop the theory of $\sigma$-functions presented here. Although the main body of this review is devoted to hyperelliptic functions the method can be extended to an arbitrary algebraic curve and new material that we added in the cases when the opposite is not stated does not suppose hyperellipticity of the curve considered.
The Influence of Media on the Stigma of Suicide when a Postsecondary Student Dies by Suicide

Abstract This study investigated whether media articles from a postsecondary institution could influence students’ stigma toward suicide after a student dies by suicide. Undergraduate participants (N = 425) read a fictitious scenario about a student suicide and were randomly assigned to a control article (no mention of the suicide) or one of three intervention articles that acknowledged the suicide and included a discussion with a psychologist, a friend of the decedent, or a suicide survivor. The stigma toward suicide survivors, particularly stereotypes, was significantly less after the three intervention articles compared to the control. No differences were found between the intervention articles or regarding the stigma toward suicide decedents. Reduced stigma toward survivors indicates that acknowledging a suicide, when possible, should be considered.
Consensus and inconsistency between different consensus documents on renal denervation worldwide: the way forward

Abstract Given the unsatisfactory hypertension control rates and high rates of non-adherence to antihypertensive medications worldwide, device therapy which can safely provide durable blood pressure-lowering effects can fulfill the unmet need. A series of second-generation randomized sham-controlled renal denervation (RDN) trials have demonstrated the efficacy and safety of RDN in a wide range of hypertensive patients. The four representative consensus documents on RDN (from the Chinese Taiwan Hypertension Society and Taiwan Society of Cardiology [THS/TSOC 2019], Asia Renal Denervation Consortium 2019, European Society of Hypertension [ESH 2021], and Society for Cardiovascular Angiography & Intervention and National Kidney Foundation [SCAI/NKF 2021]) consistently recommend RDN as an alternative or complementary treatment strategy for patients with uncontrolled hypertension. In addition, both documents from Asia further recommend that RDN can be considered as an initial treatment strategy for drug-naïve hypertensive patients. There is still inconsistency regarding whether ambulatory blood pressure monitoring should be used routinely both before and after RDN, and whether patients with a secondary cause of hypertension could be treated with RDN if their blood pressure remains uncontrolled after definitive treatment (treatment-resistant secondary hypertension). The THS/TSOC consensus provides acronyms to summarize key aspects of patient selection (RDNi2) and pre-RDN assessments (RAS). The ESH and SCAI/NKF documents recommend establishing structured pathways for clinical practice and issues regarding reimbursement. All documents identify knowledge gaps in RDN, from identifying predictors of super-responders to demonstrating effects on cardiovascular events. These gaps should be urgently filled to facilitate the wider application of this device therapy for patients with hypertension.
A multiplex analysis of phonological and orthographic networks

The study of natural language using a network approach has made it possible to characterize novel properties ranging from the level of individual words to phrases or sentences. A natural way to quantitatively evaluate similarities and differences between spoken and written language is by means of a multiplex network defined in terms of a similarity distance between words. Here, we use a multiplex representation of words based on orthographic or phonological similarity to evaluate their structure. We report that from the analysis of topological properties of networks, there are different levels of local and global similarity when comparing written vs. spoken structure across 12 natural languages from 4 language families. In particular, it is found that differences between the phonetic and written layers is markedly higher for French and English, while for the other languages analyzed, this separation is relatively smaller. We conclude that the multiplex approach allows us to explore additional properties of the interaction between spoken and written language.
Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease

Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disorder. Although most cases of ALS are sporadic, 5–10% of cases are familial, with mutations associated with over 40 genes. There is variation of ALS symptoms within families carrying the same mutation; the disease may develop in one sibling and not in another despite the presence of the mutation in both. Although the cause of this phenotypic variation is unknown, it is likely related to genetic modifiers of disease expression. The identification of ALS causing genes has led to the development of transgenic mouse models of motor neuron disease. Similar to families with familial ALS, there are background-dependent differences in disease phenotype in transgenic mouse models of ALS suggesting that, as in human ALS, differences in phenotype may be ascribed to genetic modifiers. These genetic modifiers may not cause ALS rather their expression either exacerbates or ameliorates the effect of the mutant ALS causing genes. We have reported that in both the G93A-hSOD1 and G59S-hDCTN1 mouse models, SJL mice demonstrated a more severe phenotype than C57BL6 mice. From reciprocal intercrosses between G93A-hSOD1 transgenic mice on SJL and C57BL6 strains, we identified a major quantitative trait locus (QTL) on mouse chromosome 17 that results in a significant shift in lifespan. In this study we generated reciprocal intercrosses between transgenic G59S-hDCTN1 mice on SJL and C57BL6 strains and identified survival QTLs on mouse chromosomes 17 and 18. The chromosome 17 survival QTL on G93A-hSOD1 and G59S-hDCTN1 mice partly overlap, suggesting that the genetic modifiers located in this region may be shared by these two ALS models despite the fact that motor neuron degeneration is caused by mutations in different proteins. The overlapping region contains eighty-seven genes with non-synonymous variations predicted to be deleterious and/or damaging. Two genes in this segment, NOTCH3 and Safb/SAFB1, have been associated with motor neuron disease. The identification of genetic modifiers of motor neuron disease, especially those modifiers that are shared by SOD1 and dynactin-1 transgenic mice, may result in the identification of novel targets for therapies that can alter the course of this devastating illness.
Molecular genetic associations between a prominent serotonin transporter gene polymorphism (5‐HTTLPR/rs25531) and individual differences in tendencies toward autistic traits and generalized internet use disorder in China and Germany

The serotonin transporter polymorphism 5‐HTTLPR is an extensively investigated genetic marker of autistic traits or autism spectrum disorder, and recently has also been studied in the realm of internet use disorder (IUD), yet the findings remain controversial. Therefore, the present study aimed to explore associations between 5‐HTTLPR (also including SNP rs25531) and autistic traits/IUD tendencies and to assess whether the relationship between autistic traits and IUD tendencies varies by this genetic marker in participants from China and Germany.
A simple and reliable adult uncuffed endotracheal tube for combined forceps and cryoprobe biopsy during bronchoscopy

Combined forceps and cryoprobe biopsy during bronchoscopy are increasingly used. However, the adult standard cuffed endotracheal tube (SCETT) is can be limited by general anaesthesia and neuromuscular blockade. An adult uncuffed endotracheal tube (UCETT) might provide simple and safe airway support in stable patients during forceps and cryoprobe biopsy under spontaneous respiration.
Activation of the left medial temporal gyrus and adjacent brain areas during affective theory of mind processing correlates with trait schizotypy in a nonclinical population

Abstract Schizophrenia, a severe psychiatric disorder, is associated with abnormal brain activation during theory of mind (ToM) processing. Researchers recently suggested that there is a continuum running from subclinical schizotypal personality traits to fully expressed schizophrenia symptoms. Nevertheless, it remains unclear whether schizotypal personality traits in a nonclinical population are associated with atypical brain activation during ToM tasks. Our aim was to investigate correlations between fMRI brain activation during affective ToM (ToMA) and cognitive ToM (ToMC) tasks and scores on the Schizotypal Personality Questionnaire (SPQ) and the Basic Empathy Scale in 39 healthy individuals. The total SPQ score positively correlated with brain activation during ToMA processing in clusters extending from the left medial temporal gyrus (MTG), lingual gyrus and fusiform gyrus to the parahippocampal gyrus (Brodmann area: 19). During ToMA processing, the right inferior occipital gyrus, right MTG, precuneus and posterior cingulate cortex negatively correlated with the emotional disconnection subscore and the total score of self-reported empathy. These posterior brain regions are known to be involved in memory and language, as well as in creative reasoning, in nonclinical individuals. Our findings highlight changes in brain processing associated with trait schizotypy in nonclinical individuals during ToMA but not ToMC processing.