Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of different sources and rates of nitrogen fertilization in maize (Zea mays L.).

Nitrogen fertilization is a major contributor to the increase in productivity, but also is the nutrient with the highest rates of loss, especially when applied to the surface. The aim of this study was to evaluate different sources and levels of this nutrient and its effect on maize production and weight of 1000 grains. The experiment was conducted in Patos de Minas, MG, in the 2009/2010 growing season. A randomized blocks design was used, in a factorial scheme 3 x 4 + control, with 13 treatments and four replications. The sources used were urea, ammonium nitrate and slow release urea, and doses of nitrogen applied as topdressing were 0, 40, 80, 120 and 160 kg.ha-1. After harvest, maize was weighed and converted to 13% moisture; the mass of 1,000 grains was determined by sampling the total amount of each plot. No significant difference was observed between nitrogen sources at the studied conditions, however increase in doses of all sources increased production (11,083 kg for each kg.ha-1 of N added) and mass of 1000 grains (0.1025 g for each kg.ha-1 of N).
Researching the Efficiency of Configurations of a Collective Decision-making System on the Basis of Fuzzy Logic

: Collective decision-making systems (or ensembles) based on fuzzy logic have proven their effectiveness in a number of test and practical tasks. However, the problem of configuring the system and forming the main operators remains unsolved. In this paper is a study of the effectiveness of different sequences of applying optimization procedures for the formation of the main operators of a collective decision-making system based on fuzzy logic. The effectiveness of tuning schemes for a collective decision-making system is investigated using the problem of restoring the cryolite ratio and the content of calcium and magnesium fluorides. It is shown in the research that an effective choice of the sequence of applying optimization procedures for tuning and forming the main operators can significantly increase the overall efficiency of the system.
Completeness Issues in Mobile Crowd-sensing Environments

Mobile sensors are being widely used to monitor air quality to quantify human exposure to air pollution. These sensors are prone to malfunctions, resulting in many data quality issues, which in turn impacts the reliability of analytical studies. In this work, we address the problem of data quality evaluation in mobile crowd-sensing environments, and we focus on data completeness. We introduce a multi-dimensional model to represent the data coming from the sensors in this context and we discuss different facets of data completeness. We propose quality indicators capturing different facets of completeness along with the corresponding quality metrics. We provide some experiments showing the usefulness of our proposal.
Stock Trend Prediction using Financial Market News and BERT

Stock market trend prediction is an attractive research topic since successful predictions of the market’s future movement could result in significant profits. Recent advances in language representation such as Generative Pre-trained Transformer (GPT) and Bidirectional Encoder Representations from Transformers (BERT) models have shown success in incorporating a pre-trained transformer language model and fine-tuning operations to improve downstream natural language processing (NLP) systems. In this paper, we apply the popular BERT model to leverage financial market news to predict stock price movements. Experimental results show that our proposed methods are simple but very effective, which can significantly improve the stock prediction accuracy on a standard financial database over the baseline system and existing work.
Endoscopic placement of covered versus uncovered self-expandable metal stents for palliation of malignant gastric outlet obstruction

Objective Stenting is an established endoscopic therapy for malignant gastric outlet obstruction (mGOO). The choice of stent (covered vs uncovered) has been examined in prior randomised studies without clear results. Design In a multicentre randomised prospective study, we compared covered (CSEMS) with uncovered self-expandable metal stents (UCSEMS) in patients with mGOO; main outcomes were stent dysfunction and patient survival, with subgroup analyses of patients with extrinsic and intrinsic tumours. Results Overall survival was poor with no difference between groups (probability at 3 months 49.7% for covered vs 48.4% for uncovered stents; log-rank for overall survival p=0.26). Within that setting of short survival, the proportion of stent dysfunction was significantly higher for uncovered stents (35.2% vs 23.4%, p=0.01) with significantly shorter time to stent dysfunction. This was mainly relevant for patients with extrinsic tumours (stent dysfunction rates for uncovered stents 35.6% vs 17.5%, p<0.01). Subgrouping was also relevant with respect to tumour ingrowth (lower with covered stents for intrinsic tumours; 1.6% vs 27.7%, p<0.01) and stent migration (higher with covered stents for extrinsic tumours: 15.3% vs 2.5%, p<0.01). Conclusions Due to poor patient survival, minor differences between covered and uncovered stents may be less relevant even if statistically significant; however, subgroup analysis would suggest to use covered stents for intrinsic and uncovered stents for extrinsic malignancies.
Urinary diversion after pelvic exenteration for gynecologic malignancies

Pelvic exenteration combines multiple organ resections and functional reconstruction. Many techniques have been described for urinary reconstruction, although only a few are routinely used. The aim of this review is to focus beyond the technical aspects and the advantages and disadvantages of each technique, and to include a critical analysis of continent techniques in the gynecologic and urologic literature. Selecting a technique for urinary reconstruction must take into account the constraints entailed by the natural history of the disease, patient characteristics, healthcare institution, and surgeon experience. In gynecologic oncology, the Bricker ileal conduit is the most commonly employed diversion, followed by the self-catheterizable pouch and orthotopic bladder replacement. Continent and non-continent diversions present similar immediate and long-term complication rates, including lower tract urinary infections and pyelonephritis (5–50%), ureteral stricture (3–27%), urolithiasis (5–25%), urinary fistula (5%), and more rarely, vitamin B12 deficiency and metabolic acidosis. Urinary incontinence for the ileal orthotopic neobladder (50%), stoma-related complications for the Bricker ileal conduit (24%), difficulty with self-catheterization (18%) for the continent pouch, and induction of secondary malignancy for the ureterosigmoidostomy (3%) are the most relevant technique-related complications following urinary diversion. The self-catheterizable pouch and orthotopic bladder require a longer learning curve from the surgical team and demand adaptation from the patient compared with the ileal conduit. Quality of life between different techniques remains controversial, although it would seem that young patients may benefit from continent diversions. We consider that centralization of pelvic exenteration in referral centers is crucial to optimize the oncologic and functional outcomes of complex ablative reconstructive surgery.
Compliance of Published Randomized Controlled Trials on the Effect of Physical Activity on Primary Dysmenorrhea with the Consortium’s Integrated Report on Clinical Trials Statement: A Critical Appraisal of the Literature

Background: Randomized Controlled Trials (RCTs) are reliable methods for the evaluation of treatment effectiveness, which should be rigorous and must report with clarity. This study aimed to assess the compliance of published RCTs about the effect of physical activity on primary dysmenorrhea with the CONSORT 2017 statement. Materials and Methods: In this study, the review of literature was carried out based on Consolidated Standards Of Reporting Trials (CONSORT). All the clinical trials focused on the effect of the physical activity on primary dysmenorrhea indexed in Web of Science, Pubmed, Scopus, Google Scholar, Science Direct, Embase, Magiran and Scientific Information Database (SID) were searched using keywords of dysmenorrhea, randomized clinical trial, physical activity and exercise from 2000 to 2019. Out of 1423 articles, 30 RCTs were critically appraised using CONSORT 2017 checklist. The reporting quality score of articles was identified between zero and 43. Results: The compliance rate with the CONSORT checklist was 55.58%. The mean (SD) score of the reporting quality was 23.37 (-5.15) with a minimum of 16 and a maximum of 37. The maximum weakness was in reporting the sample size and full trial protocol 23.33% and 6.67% respectively. Regarding new items of the consort 2017, if the blinding was not possible, the description of any attempts to limit bias was not described in 70% of articles. Conclusions: Reporting sample size, trial protocol, method of blinding, and control of bias are issues that require more attention in reporting of RCT studies. We recommend that the authors use the CONSORT 2017 statement for conducting and reporting the clinical trials.
Depression and anxiety associated with functional bowel disorders and its impact on quality of life: A cross-sectional study

Background: Functional bowel disorder (FBD) is conceptualized as a “biopsychosocial disorder. ” Psychological factors are important moderators of symptom severity and persistence, treatment seeking and response to treatment. We investigated psychological factors and quality of life (QOL) in patients with FBD. Methods: Seventy patients visiting the department of medical gastroenterology diagnosed as FBD were included in the study. Severity of FBD was rated with FBD Severity Index. The Depression, Anxiety, and Stress Scale was applied and patients were divided into two groups, i.e., with moderate stress (Group A) and with severe stress (Group B). QOL in both the groups was assessed by WHOQOL-BREF Scale. Chi-square, t-test was done to compare the groups. Regression analysis was done to find predictors of poor QOL. P<0.05 was taken as significant. Results: Patients of Group B had a longer duration of illness and had higher prevalence of depressive disorder (P = 0.03) in comparison to patients in Group A, who had higher prevalence of anxiety disorders (P = 0.06). Severity of FBD was positively correlated with depression (r = 0.8; P = 0.02). Physical and psychological QOL was significantly impaired in Group B patients having depression (P = 0.02; P = 0.03). Regression analysis showed a positive trend for presence of depressive disorder (P = 0.05), anxiety disorder (P = 0.08) and severity of FBD (P = 0.09) as predictors of poor QOL. Conclusion: In our study, the high prevalence of stress, anxiety and depression in patients with FBD indicates the need for routine screening of such symptoms along with a collaborative and holistic treatment approach. Several etiological perspectives explaining the complex gut–brain interaction are also provided.
Mechanistic Modeling of Wet Stirred Media Milling for Production of Drug Nanosuspensions

Drug nanocrystals have been used for a wide range of drug delivery platforms in the pharmaceutical industry, especially for bioavailability enhancement of poorly water-soluble drugs. Wet stirred media milling (WSMM) is the most widely used process for producing dense, stable suspensions of drug nanoparticles, also referred to as nanosuspensions. Despite a plethora of review papers on the production and applications of drug nanosuspensions, modeling of WSMM has not been thoroughly covered in any review paper before. The aim of this review paper is to briefly expose the pharmaceutical scientists and engineers to various modeling approaches, mostly mechanistic, including computational fluid dynamics (CFD), discrete element method (DEM), population balance modeling (PBM), coupled methods, the stress intensity–number model (SI–SN model), and the microhydrodynamic (MHD) model with a main focus on the MHD model for studying the WSMM process. A total of 71 studies, 30 on drugs and 41 on other materials, were reviewed. Analysis of the pharmaceutics literature reveals that WSMM modeling is largely based on empirical, statistically based modeling approaches, and mechanistic modeling could help pharmaceutical engineers develop a fundamental process understanding. After a review of the salient features and various pros–cons of each modeling approach, recent advances in microhydrodynamic modeling and process insights gained therefrom were highlighted. The SI–SN and MHD models were analyzed and critiqued objectively. Finally, the review points out potential research directions such as more mechanistic and accurate CFD–DEM–PBM simulations and the coupling of the MHD–PBM models with the CFD.
Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells

Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific antigens (TSAs). Recent work has shown that gene-expression patterns within the mTEC compartment are heterogenous and include multiple differentiated cell states. To further define mTEC development and medullary epithelial lineage relationships, we combined lineage tracing and recovery from transient in vivo mTEC ablation with single-cell RNA-sequencing in Mus musculus. The combination of bioinformatic and experimental approaches revealed a non-stem transit-amplifying population of cycling mTECs that preceded Aire expression. We propose a branching model of mTEC development wherein a heterogeneous pool of transit-amplifying cells gives rise to Aire- and Ccl21a-expressing mTEC subsets. We further use experimental techniques to show that within the Aire-expressing developmental branch, TSA expression peaked as Aire expression decreased, implying Aire expression must be established before TSA expression can occur. Collectively, these data provide a roadmap of mTEC development and demonstrate the power of combinatorial approaches leveraging both in vivo models and high-dimensional datasets.
High-intensity focused ultrasound (HIFU) therapy for benign thyroid nodules: a 3-year retrospective multicenter follow-up study

Abstract Background Outcomes of high-intensity focused ultrasound (HIFU), as a non-surgical treatment option for benign symptomatic thyroid nodules, has mainly been based on single-center studies and short-term follow-up. Therefore, we assessed the safety, and long-term efficacy of HIFU in benign thyroid nodules among four centers with expertise in thyroid mini-invasive procedures. Patients and methods Retrospective three year follow-up study in four European centers, treating solid benign thyroid nodules causing pressure symptoms and/or cosmetic concerns. Nodule volume reduction was assessed at 1, 3, 6, 12, 24, and 36 months post-treatment. Technical efficacy, defined as a volume reduction rate (VVR) >50% was evaluated at 6, 12, 24 and 36 months. Predictive factors of efficacy were assessed using logistic models. Complications and side effects were classified according to the Interventional Radiology Guidelines and changes in local symptoms were scored on a visual-analog scale. Results Sixty-five patients (mean age 51.1 ± 14.0 years; 86.2% women) with a single thyroid nodule and a mean baseline nodule volume of 9.8 ± 10.3 mL were treated with a mean energy of 7.1 ± 3.1 kJ (range: 2.0 to 15.5 kJ). Median nodule volume reduction was 31.5% (IQR: −38.6% to −23.1%) at 12 months and 31.9% (IQR: −36.4% to −16.1%) at 36 months. Technical efficacy was obtained in 17.2% of cases at 6 months, 17.8% at 12 months, 3.4% at 24 months, and 7.4% at 36 months. The number of treated pixels and the mean energy delivered were positively correlated to VRR at 1, 6 and 12 months. The risk of treatment failure decreased by 4.3% for each additional unit of energy delivered. The procedure duration was inversely correlated with treatment failure (OR 1.043, 95% CI: 1.011–1.083; p = 0.014). Improvement of cervical pressure symptoms or cosmetic complaints were observed in less than 15% of the cases at 12, 24 and 36 months. Horner’s syndrome occurred in one case (1.5%) and minor complications, not requiring treatment, in three (4.6%) patients. No change in thyroid function was registered. Conclusions HIFU carried a low risk of complications. A single treatment resulted in a 30–35% thyroid nodule volume decrease within one year, reduction that remained stable for 2 years. Outcomes varied significantly between centers with different HIFU expertise. Focus on improved HIFU technology, adequate training, and appropriate selection of patients is needed to achieve efficacy comparable to other thermal ablation procedures.
Cooling efficiency of vests with different cooling concepts over 8-hour trials

Abstract As frequency and severity of heat waves are increasing, personal cooling systems are being considered as a tool to mitigate heat strain in workers in various occupational settings. This study assessed cooling capacities (C; W·h·m−2) of various commercially available vests using different cooling concepts. Measurements were conducted over 8 h in a climatic chamber (Ta: 35 °C, RH: 35 %) using a thermal manikin (Ts: 35 °C). Cooling power (P) and duration of efficient cooling (tc) determined the C value of each vest. Among the cooling concepts the active cooling vests were the most efficient, extracting 331 W·h·m−2, followed by the vests with phase change material (PCM) inserts, hybrid and evaporative vests, extracting a maximum of 164 W·h·m−2, 146 W·h·m−2 and 113 W·h·m−2, respectively. While some vests with PCM inserts provided intense but shorter cooling, evaporative vests provided mild but longer cooling throughout. Practitioner summary: The study assessed the cooling capacity of commercially available vests, using a thermal manikin. The vests present an affordable solution in various occupational settings where air-conditioning is not an option. A range of cooling capacities among different cooling concepts and vests of the same category were noted. Abbreviations: ACVs: air-cooled vests; LCVs: liquid-cooled vests; ECVs: evaporative cooling vests; HCVs: hybrid cooling vests; PCVs: phase-change cooling vests; PCM: phase change material; C: cooling capacity; Rt: thermal resistance; Re: evaporative resistance; Re (%): relative evaporative resistance; P: cooling power; Pmax: maximal cooling power; Pavg: average cooling power; tc: cooling duration; AUC: area under the curve; Ta: ambient temperature; RH: relative humidity; va: chamber air flow; Ts: manikin surface temperature
Characteristics of cancer patients with COVID-19 in a cancer hospital.

BACKGROUND Cancer patients are vulnerable to the coronavirus disease (COVID-19) given their compromised immune system. The purpose of this study was to describe the presenting symptoms, inpatient stay trajectory, and survival outcomes, for cancer patients infected with COVID-19; who presented to the emergency department (ED) of a single center during the early months of the pandemic. METHODS We reviewed the electronic medical records of all cancer patients diagnosed with COVID-19 at our institution for demographic information, clinical presentation, laboratory findings, treatment intervention and outcomes. All patients had at least 14 days of follow-up. We determined their survival outcomes as of August 5, 2020. RESULTS Twenty-eight cancer patients were diagnosed with COVID-19, and 16 (57%) presented to the ED during the study period. The median age of patients who presented to the ED was 61 years, 69% were women, and the median length of hospitalization was 11 days. There was no difference between the groups (ED vs. no ED visit) for demographics, treatment status or solid tumor versus hematologic malignancies or treatments. Dyspnea was a significant symptom with 67% of ED patients experiencing it versus only 17% of those that did not come to the ED (P=0.009). Do not resuscitate orders were initiated in eight patients, as early as two days from ED presentation and two of these patients died, while 88% of patients were discharged alive. CONCLUSIONS Most cancer patients with COVID-19 infection admitted though the ED experienced dyspnea and were discharged from the hospital. We did not notice a statistically significant difference between cancer types or type of therapy. A broad differential is of utmost importance when caring for cancer patients with COVID-19 due to the complexity of this population. Early goals of care discussion should be initiated in the ED.
Blood Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term Fasting

Background We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results Subjects underwent a multidisciplinary fasting program with a daily intake of ≈250 kcal. Weight and stress scores decreased during fasting, and the well‐being index increased, documenting a good tolerability. BP mean values decreased from 126.2±18.6/81.4±11.0 to 119.7±15.9/77.6±9.8 mm Hg (mean change, −6.5/3.8 mm Hg). BP changes were larger for hypertensive nonmedicated subjects (>140/90 mm Hg) and reduced by 16.7/8.8 mm Hg. This reduction reached 24.7/13.1 mm Hg for hypertensive nonmedicated subjects (n=76) with the highest BP (>160/100 mm Hg). In the normotensive group, BP decreased moderately by 3.0/1.9 mm Hg. Interestingly, we documented an increase of 6.3/2.2 mm Hg in a subgroup of 69 female subjects with BP <100/60 mm Hg. In the hypertensive medicated group, although BP decreased from 134.6/86.0 to 127.3/81.3 mm Hg, medication was stopped in 23.6% of the subjects, whereas dosage was reduced in 43.5% and remained unchanged in 19.4%. The decrease in BP was larger in subjects fasting longer. Baseline metabolic parameters, such as body mass index and glucose levels, as well as age, can be used to predict the amplitude of the BP decrease during fasting with a machine learning model. Conclusions Long‐term fasting tends to decrease BP in subjects with elevated BP values. This effect persisted during the 4 days of stepwise food reintroduction, even when subjects stopped their antihypertensive medication. Registration URL: https://www.drks. de/drks_web/; Unique identifier: DRKS00010111.
Reciprocity in Conversation

This work provides initial evidence of reciprocity in conversation. We tested whether conversations with contribution imbalances brought on by task demands contained attempts to redress the created imbalance. Pairs of participants identified public art via phone communication. One member of the pair, the director, gave instructions using a map while the other, the follower, walked around a small town finding public art pieces. Later, trained raters coded the participants’ transcribed conversational turns as either on-task or off-task. As observed in similar studies, directors spoke more in on-task portions of the dialogue. We newly found that in off-task communication, followers spoke more than their directors and used a greater number of words per turn than their directors. We interpret the pattern as reflecting behaviors leading toward balance in contributions across the conversation as a whole, a process we refer to as reciprocity in conversation.