Miracle-dz/UniFAR-FTUs huggingface dataset:
Factores fetales asociados a prematuridad

Objetivo: identificar los factores fetales asociados a la prematuridad en el Hospital Vicente Corral de Cuenca-Ecuador en el periodo 2016-2017. Materiales y métodos: se diseñó un estudio de casos y controles, con contrastación doble, utilizando dos controles de igual edad posnatal y sexo por cada caso. De una población homogénea de neonatos menores de una semana de vida nacidos en el Hospital Vicente Corral de Cuenca-Ecuador en el periodo 2016-2017, se obtuvo una muestra de 160 casos y 320 controles. Se realizó un análisis estadístico descriptivo e inferencial, para establecer la asociación estadística se utilizó OR, IC 95% y significancia estadística con p-valor <0,05. Resultados: en el grupo de casos se encontró 75,0% prematuros tardíos y en el grupo control 62,5% nacidos a término completos. La prematuridad se asoció con: gemelaridad OR=7,36; IC 95%=2,61-20,74; p=0,000. Antecedente de hermano nacido pretérmino OR=2,96; IC 95%=1,61-5,44; p=0,000. Peso de nacimiento menor al percentil 10 OR=1,66; IC 95%=1,01-2,75; p=0,048. Los factores que no se asociaron con prematuridad fueron: sexo χ2=0,100; p-valor=0,752. Malformaciones congénitas mayores OR=2,02; IC 95%=0,40-10,12; p=0,405. Conclusiones: en el presente estudio predominaron en el grupo de casos los pretérmino tardíos y en el grupo control los nacidos a término completos. Los factores fetales verdaderamente asociados a prematuridad fueron: gemelaridad, el antecedente de hermano nacido pretérmino y peso de nacimiento menor al percentil 10; el sexo del neonato y las malformaciones congénitas mayores no se asociaron a la prematuridad.
Study on the effect of aluminum sulfate treatment on postharvest life of the cut rose 'Boeing' (Rosa hybrida cv. Boeing).

This experiment was carried out to investigate the effect of aluminum sulfate on postharvest life of a cut rose cultivar (Rosa hybrida ’ Boeing’). Flower stems were placed in aluminum sulfate solutions(0, 150 mgl -1 , 300 mgl -1 , 150 mgl -1 +sucrose 3%, 300 mgl -1 +sucrose 3%) until the end of vase life as a standard treatment and distilled water was used as control treatment. Aluminum sulfate treatment (150 and 300 mgl -1 ) extended the vase life of flowers from 9 days (control) to 12 and 12.3 days respectively. Aluminum sulfate (150 and 300 mgl -1 ) application resulted in a significant solution uptake until the end of the vase life. At last measurement the relative fresh weight of flowers treated with 150 and 300 mgl -1 aluminum sulfate showed significant higher values than the other levels of treatment due to more water uptake. Aluminum sulfate (150 and 300 mgl -1 ) had positive effect on flower bud opening and increased flower diameter compared to control.
THE EFFECT OF OBESITY ON INCIDENCE OF PREECLAMPSIA ON PREGNANCY: A Systematic Literature Review

Preeclampsia is a complication that is very dangerous and can influence 2-8% of pregnancy. Globally, more than 287,000 women die every year due to complications in pregnancy. 10-15% of them are caused by preeclampsia. Preeclampsia remains a significant problem in threatening health in developed and developing countries. However, the impact of preeclampsia is more severe in developing countries, where treatment may be ineffective because of the delay of treatment. Obesity is the most common problem in midwifery that affects maternal and child health since it may cause short-term and long-term problems for mothers, such as increasing the risk of gestational diabetes and preeclampsia. The purpose of this systematic literature review is to conclude and explore the literature related to obesity and the incidence of preeclampsia in pregnant women. Systematic literature review utilized Pubmed, Proquest and Ebsco databases from 2008 to 2018. From the 1646 initial articles identified, this study analyzed 7 articles that fulfilled the criteria. The study found that the factors affecting the occurrence of eclampsia were maternal age, primiparas, maternal obesity, history of preeclampsia, and maternal education. It was found that the high BMI of a mother before pregnancy (Pre-pregnancy) is a risk factor for the occurrence of preeclampsia. Besides, overweight and obese during pregnancy can cause preeclampsia, and these factors can also cause severe preeclampsia. Keywords: obesity, preeclampsia, pregnancy
Evaluation of osmotic stress tolerance in transgenic Arabidopsis plants expressing Solanum tuberosum D200 gene

ABSTRACT Developing efficient stress-tolerant crops through genetic engineering remains one of the major challenges for plant biologists. Approximately 20–40% genes of the known eukaryotic genomes, encode proteins of unknown function which lack currently defined motifs or domains. In a previous study, large-scale yeast functional screening approach in potato was used and 69 genes were reported to have enhanced hyperosmotic stress tolerance of yeast. Twelve out of 69 genes were found to have stress tolerance against multiple stresses. One of those 12 identified genes (StD200) encodes a protein of unknown function. In this study, we evaluated the tolerance against PEG-induced osmotic stress in transgenic Arabidopsis plants expressing putative abiotic stress-associated D200 gene. The D200 plants exhibited higher accumulation of chlorophyll and proline and reduced levels of oxidants compared to the wild-type (WT) control plants when subjected to PEG-induced osmotic stress conditions. Our quantitative Real-Time PCR results also suggested an increased accumulation of mRNA transcripts of genes encoding three major antioxidant enzymes in PEG-treated D200 plants compared to WT. Furthermore, improved photosynthetic parameters, F v/F m and performance index in PEG-treated D200 plants indicated that potato D200 gene is a potential candidate gene for developing stress-tolerant crops in future.
Ineffectiveness of Insecticide Bendiocarb Against a Cimex lectularius (Hemiptera: Cimicidae) Population in Paris, France

Abstract Bed bugs, nocturnal ectoparasites adapted to feed on humans, have demonstrated a global resurgence since 1990s, presumably due to increased international travel and insecticide resistance. Resistance to insecticides has restricted the ability to manage bed bug populations. We evaluated the susceptibility of Cimex lectularius L. (Hemiptera: Cimicidae) collected from five districts in Paris against bendiocarb, a carbamate insecticide. The susceptible strain of C. lectularius from London included in our experiments as a control. Mortality of adult bed bugs was assessed after exposure to a fixed concentration of bendiocarb (80%) at intervals ranging from 15 min to 72 h. Mortality in samples ranged from 14% in Bobigny to 0% in Paris 15th arrondissement and Drancy. Bioassays with bendiocarb insecticide on C. lectularius revealed high levels of resistance in Paris.
GAPIN: Grouped and Aligned Protein Interface Networks

Summary GAPIN is a web-based application for structural interaction network analysis among any type of PDB molecules, regardless of whether their interfaces are between chain-chain or chain-ligand. A special emphasis is given to graph clustering, allowing users to scrutinize target contexts for ligand candidates. We show how GAPIN can be used to unveil underlying hydrophobic patterns on a set of peptidase-inhibitor complexes. In another experiment, we show there is a positive correlation between cluster sizes and the presence of druggable spots, indicating that the clustering may discriminate the higher complexity of these hot subnetworks. Availability and implementation GAPIN is freely available as an easy-to-use web interface available at https://pinga.unifei.edu.br. Contact biharck@ufmg.br, carlos.silveira@unifei.edu.br.
ROOT-TO-SHOOT COMMUNICATION AND ITS SIGNAL CROSS TALK IN PLANTS: A PHYSIOLOGICAL AND AGRONOMIC PERSPECTIVE

The plant roots perceive and can respond to drying soil by transferring nHRS (non-hydraulic root-sourced signal) to aboveground plant parts deprived of any noticeable changes in water status of leaves. The nHRS has therefore been confirmed as a distinctive positive "quick-alert" reaction to soil drying in plants, triggering sequential physiological and molecular signalling pathways. Cross-talk infers to as occurrences where single or more constituents of a signal transduction pathway affect the others and might be accomplished via many pathways. We summarize the current progress regarding ABA-led root-to-shoot signals in relation to signalling cross-talk. Across signalling cross-talk, nitric oxide, reactive oxygen species, soil moisture threshold and others are broadly documented as conciliator of cross-talk throughout stress signalling. Here, we introduce a description of nHRS on stimulating the onset and process of signal cross-talk such as nitric oxide, reactive oxygen species, organic osmolytes, anti-oxidants, minerals and phytohormones. In particular, we have attempted to sketch out a flow chart of drought stress signal crosstalk with abscisic acid (ABA) and cytokinins (CTK/CK) as the center to describe eco-physiological link with multiple long-distance signalling pathways in plants. Eco-physiological framework and mutual interplay of complex signal elements in agronomic perspective during the operation of nHRS are also reviewed.
Blood parameters and parasitic load in Sardinops sagax (Jenyns, 1842) from Todos Santos Bay, Baja California, Mexico

Some studies have characterized and evaluated the parasitic load of the Pacific sardine. However, there are few studies related to its physiology and parasites load. This study aimed to evaluate the blood parameters and the abundance of helminth parasites of sardines obtained from two samples from Todos Santos Bay during autumn 2013. The digenea Myosaccium ecaude parasite was the only species registered. Sardines had a prevalence of 28%, an average abundance of 25 and an intensity of 7 parasites. There were no statistically significant differences ( P > 0.05) in most of the analyzed blood parameters (red blood cell count, hematocrit, leukocyte cellular differentiation, mean corpuscular volume, total protein, glucose, alanine aminotransferase, osmotic pressure, Na, K, and pH) of fish with and without parasites, except in white blood cell count and in Ca concentration that showed a marked decrease. The relationship between parasite abundance and blood parameters, based on the results of this study, it is not clear due to the low parasitic load.
Parasite burden and reproductive success

Reproduction is fundamental for passing on genes and secure species survival. One crucial point of this is mate choice, mating with an unbeneficial partner, they risk less advantageous offspring than if a better mate had been chosen. To be able to make these choices, sexual signals, or ornaments, are very useful tools. Many studies have concluded the positive relationship between sexual signals and reproductive success, meaning that with better, brighter and more symmetric ornaments comes a higher reproductive success. Females are usually the ones that decide who is allowed to mate with them, therefore it is the males that carry ornaments. Additionally, studies have been made on how parasites can affect these ornaments but not many studies have covered the whole path, from parasite to reproductive success. For this work my main question is if there is any general correlation between parasite burden and reproductive success. Firstly, it is important to know some basic background about parasitism and how parasites can infect their host. Parasites are categorized in two ways, ecto- and endoparasites, i.e. parasites living on the surface respectively on the inside of the hosts’ body. One phylum of endoparasites has been mentioned more trequently than others among different studies - apicomplexans. The apicomplexan parasites presented in this work are Leucocytozoon spp. and Plasmodium spp. Additionally, one specific ectoparasite occurs, Carnus hemapterus, phylum arthropoda. Secondly, the effect of parasite infection on the host. Higher parasite burden takes energy and resources from the host who thereby cannot afford to invest as much in sexual signals or brightly colored ornaments. This will lead to lower chance for mating, it has been shown that ornaments play an important role in sexual selection and mate choice, they act as honest signals for quality. To summarize, a majority of the studies presented in this work point in the same direction and I can from them conclude that parasites most likely affect sexual signals negatively, leading to lower chance for mating and thereby lower reproductive success. Though, there are differences in opinion and some authors state that there is a positive correlation between parasite burden and sexual signals, in which case reproductive success would benefit.
PENERAPAN PEMBELAJARAN BERBASIS DISCOVERY LEARNING MELALUI METODE TALKING STICK UNTUK MENINGKATKAN PEMAHAMAN KONSEP GERAK LURUS

Tujuan penelitian ini untuk mengetahui peningkatan pemahaman konsep gerak lurus melalui pembelajaran berbasis discovery learning melalui metode talking stick. Penelitian ini merupakan jenis penelitian deskriptif eksploratif. Subjek penelitian adalah siswa kelas X MIA 1 SMA Islam Al-Falah Jambi sebanyak 29 siswa. Teknik pengumpulan data melalui tes pemahan konsep, lembar observasi keterampilan peserta didik dan dokumentasi. Teknik analisis data dilakukan secara deskriptif. Peserta didik mengikuti pembelajaran discovery learning melalui metode talking stick pada materi gerak lurus. Peserta didik antusias untuk menjawab pertanyaan, mengemukakan pendapat, dan memberikan tanggapan terhadap jawaban teman. Hasil tes pemahaman konsep diperoleh rata-rata 77,80. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa pembelajaran berbasis discovery learning melalui metode talking stick dapat meningkatkan pemahaman konsep Gerak Lurus.
Korelasi Kontrol Glikemik dengan HDL dan Small-Dense LDL pada Penderita Diabetes Melitus dengan Komplikasi Jantung Koroner di RSUP Dr. Kariadi Semarang, Jawa Tengah

Blood glucose level could be measured before 2-3 months using glycated haemoglobin (HbA1c). In diabetes mellitus (DM) the size of low-density lipoprotein (LDL-K) often changes to a small size, called small dense LDL-K sdLDL) which is atherogenic and low high-density lipoprotein (HDL) level. High HbA1c indicates uncontrolled glucose levels and often cause complications of coronary heart disease (CHD). This is a further investigation from the previous one about ”The Relationship between HbA1c with LDL and Apo B in DM patients with cardiac complications. " This study used analytical, cross-sectional design. Thirty patients DM with CHD complications were examined for HbA1C levels via the Exchange-HPLC ion methods, HDL-K and LDL-K by enzymatic colourimetric methods and apo B by the immunoturbidimetry methods. The relationship between variables was analyzed by the Pearson correlation test.The mean level of HbA1c was 8.72%, male HDL was 35.67 mg / dl, female was 39.57 mg / dl, LDL-K was 110.64 mg / dl, apo B was 111.88 mg / dl and sdLDL was 1, 02. A strong negative relationship between HbA1c and HDL levels for both men and women with r = 0.647; r = 0.675 with significance level p = 0.017; p = 0.008. Whereas HbA1c with sd-LDL has a weak negative relationship, but not significant (r = -0.352; p = 0.057). Hence, lipid profile measurement can be considered to monitor risk of cardiovacular diseases, particularly in those with abnormal blood glucose metabolism. Keeywords: DM with CAD, HbA1c, HDL, sd-LDL, Dr. Kariadi Hospital Semarang
Using SSR markers from Prunus genus for wild cherry genotyping

Prunus genus include fruit and wooden species. Because its economic importance, both phenotypic and genetic markers have been developed and used in genetic studies. Among them, for their versatility, degree of transferability and repeatability, some microsatellite sets have been developed for several species from this genus.Although they have been successfully used inside the Rosaceae family, their transferability to other species and/or provenances different for what they were designed, must be first assessed. Thus, the higher the number of markers assessed, the higher their applicability for performing genetic studies. Hence, the functionality of 20 microsatellite markers designed for P. persica (L.) Batsch and P. avium L. were tested for genotyping a wild cherry progeny for wood production. Scorable amplifications and reasonably high polymorphism were registered for 13 out of 20 SSR assessed, averaging 7.7 alleles/ locus. The observed heterozygosity ranges from 0.513 to 0.946; with allelic frequencies below 0.50, except for two loci. The individual discriminative power goes from 0.045 to 0.250; while the combined random probability of identity was as low as 1.8114x10-13, allowing to identify and to differentiate unambiguously individuals in the sample formed by 36 trees. According these results, this set has showed its potential for genotyping plus trees from wild cherry for wood production.
Present and potential impacts of waste from poultry production on the environment

Poultry production is associated with greenhouse gas (GHG) emissions but at a much lower extent than other livestock. Global production of nitrogen from poultry excreta has been estimated at about 3.29 million metric tons for meat type chickens (the average of two estimates with different assumption of 2.65 and 3.94 million metric tons) and 2.36 million metric tons for laying hens. These estimates are markedly below earlier estimates, suggesting that the issues related to loading are of a markedly smaller magnitude than previously envisioned. However, if it is assumed that 2% of the nitrogen is lost as nitrous oxide with a global warming potential (GWP) of 298 CO2 equivalents (eq.) per unit as GHG, poultry waste is contributing 33.7 million metric tons of CO2 eq./year or 0.0337 gigatons (Gt) CO2 eq./yr. This represents only 0.64% of agricultural GHG emissions. The preferred method for the disposal of poultry excreta is land application as a fertiliser with the aggregate of livestock and poultry excreta being applied to 0.3 million hectares in the USA. The environmental consequences of excreta in litter include the release of ammonia and nitrous oxide (a GHG) together with contamination of ground and surface water with nitrate, phosphate and pathogens. Alternative approaches to utilise used litter are the following: combustion, gasification, digestion and feeding to ruminants. There is scope to reduce the environmental impact of poultry production on the environment.
Magnetic Isotope Effect in Chemistry and Biochemistry

Introduction Energy & angular momentum as the reaction controlling factors Spin control of chemical reactions Magnetic isotope effect (MIE) Kinetics of isotope fractionation Physics of the MIE MIE for hydrogen-deuterium dyad 13C MIE: controlling factors Oxygen MIE Silicon MIE MIE for sulphur, germanium & tin nuclei Uranium MIE Mercury MIE Magnesium isotope effects Microwave effects Index.
Effects of the (Pro)renin Receptor on Cardiac Remodeling and Function in a Rat Alcoholic Cardiomyopathy Model via the PRR-ERK1/2-NOX4 Pathway

Alcoholic cardiomyopathy (ACM) caused by alcohol consumption manifests mainly as by maladaptive myocardial function, which eventually leads to heart failure and causes serious public health problems. The (pro)renin receptor (PRR) is an important member of the local tissue renin-angiotensin system and plays a vital role in many cardiovascular diseases. However, the mechanism responsible for the effects of PRR on ACM remains unclear. The purpose of this study was to determine the role of PRR in myocardial fibrosis and the deterioration of cardiac function in alcoholic cardiomyopathy. Wistar rats were fed a liquid diet containing 9% v/v alcohol to establish an alcoholic cardiomyopathy model. Eight weeks later, rats were injected with 1 × 109v.g. /100 μl of recombinant adenovirus containing EGFP (scramble-shRNA), PRR, and PRR-shRNA via the tail vein. Cardiac function was assessed by echocardiography. Cardiac histopathology was measured by Masson's trichrome staining, immunohistochemical staining, and dihydroethidium staining. In addition, cardiac fibroblasts (CFs) were cultured to evaluate the effects of alcohol stimulation on the production of the extracellular matrix and their underlying mechanisms. Our results indicated that overexpression of PRR in rats with alcoholic cardiomyopathy exacerbates myocardial oxidative stress and myocardial fibrosis. Silencing of PRR expression with short hairpin RNA (shRNA) technology reversed the myocardial damage mediated by PRR. Additionally, PRR activated phosphorylation of ERK1/2 and increased NOX4-derived reactive oxygen species and collagen expression in CFs with alcohol stimulation. Administration of the ERK kinase inhibitor (PD98059) significantly reduced NOX4 protein expression and collagen production, which indicated that PRR increases collagen production primarily through the PRR-ERK1/2-NOX4 pathway in CFs. In conclusion, our study demonstrated that PRR induces myocardial fibrosis and deteriorates cardiac function through ROS from the PRR-ERK1/2-NOX4 pathway during ACM development.
Long-term reduction of short wavelength light affects sustained attention and visuospatial working memory

The short wavelength, i.e. blue light, is crucial for non-image forming effects such as entrainment of circadian system. Moreover, many studies showed that blue light enhances alertness and performance in cognitive tasks. However, most of scientific reports in this topic is based on studies using short exposure to blue or blue-enriched light and only few focused on the effects of its reduced transmittance, especially in longer period. The latter could potentially give insight into understanding if age-related sleep problems and cognitive decline are related to less amount of blue light reaching the retina, as our lenses become more yellow with age. In this study, we investigated the effects of prolonged blocking of blue light on cognitive functioning, in particular - sustained attention and visuospatial working memory, and sleep. We used amber contact lenses reducing transmittance of blue light by approximately 90% for the period of four weeks on a group of young, healthy participants. No changes were observed for measurements related to sleep and sleep-wake rhythm. The significant effect was shown both for sustained attention and visuospatial memory, i.e. the longer blocking the blue light lasted, the greater decrease in performance was observed. Additionally, the follow-up session was conducted (approximately one week after taking off the blue-blocking lenses) and revealed that in case of sustained attention this detrimental effect of blocking BL is fully reversible. Our findings provide evidence that prolonged reduction of BL exposure directly affects human cognitive functioning regardless of sleep-related conditions.