Miracle-dz/UniFAR-FTUs huggingface dataset:
To treat or not to treat; the clinical dilemma of atypical squamous cells of undetermined significance (ASC‐US)

Objective. Management of patients diagnosed on cervical smears with twice consecutively atypical squamous cells of undetermined significance (ASC‐US) remains a clinical dilemma. We describe a follow‐up of aggressive vs. less aggressive colposcopic treatment in order to determine which treatment is preferable. Design. Retrospective cohort study with a follow‐up of 10 years. Setting. Two hospitals in The Netherlands. Population. Women referred for primary colposcopy with two consecutive ASC‐US smears (n=230) to either one of the two hospitals. Methods. In one hospital, patients underwent direct loop excision of all colposcopically detected abnormalities, even if not suspected for cervical intraepithelial neoplasia (CIN; aggressive strategy; n=118). In the other hospital, a less aggressive policy was followed when low‐grade CIN lesions were suspected at colposcopy (less aggressive strategy; n=112). Main Outcome Measures. The number of loop excisions, detection of CIN lesions and cytological follow‐up of both groups. Results. Less aggressive management resulted in less loop excisions (p<0.001). At initial colposcopy, the aggressive group showed a 10‐fold incidence of histologically detected CIN lesions compared with the less aggressive group (1.8 vs. 19.5%). During 10 years of follow‐up, both groups showed the same percentages of CIN lesions (8.1 vs. 8.4%). Aggressive management resulted in faster normalization of cervical smears (p<0.001). However, at final follow‐up, there was no statistical difference in the percentage of normalization of cervical smears between both groups. Conclusions. Aggressive and less aggressive colposcopic strategies are equally safe and show good clinical outcomes. Treatment decisions, however, must be adjusted to women's individual demands.
Volatility, Money Market Rates, and the Transmission of Monetary Policy

Central banks typically control an overnight interest rate as their policy tool, and the transmission of monetary policy happens through the relationship of this overnight rate to the rest of the yield curve. The expectations hypothesis, that longer-term rates should equal expected future short-term rates plus a term premium, provides the typical framework for understanding this relationship. We explore the effect of volatility in the federal funds market on the expectations hypothesis in money markets. We present two major results. First, the expectations hypothesis is likely to be rejected in money markets if the realized federal funds rate is studied instead of an appropriate measure of the expected federal funds rate. Second, we find that lower volatility in the bank funding markets market, all else equal, leads to a lower term premium and thus longer-term rates for a given setting of the overnight rate. The results appear to hold for the US as well as the Euro Area and the UK. The results have implications for the design of operational frameworks for the implementation of monetary policy and for the interpretation of the changes in the Libor-OIS spread during the financial crisis. We also demonstrate that the expectations hypothesis is more likely to hold the more closely linked the short- and long-term interest rates are.
Feline Foamy Virus-Based Vectors: Advantages of an Authentic Animal Model

New-generation retroviral vectors have potential applications in vaccination and gene therapy. Foamy viruses are particularly interesting as vectors, because they are not associated to any disease. Vector research is mainly based on primate foamy viruses (PFV), but cats are an alternative animal model, due to their smaller size and the existence of a cognate feline foamy virus (FFV). The potential of replication-competent (RC) FFV vectors for vaccination and replication-deficient (RD) FFV-based vectors for gene delivery purposes has been studied over the past years. In this review, the key achievements and functional evaluation of the existing vectors from in vitro cell culture systems to out-bred cats will be described. The data presented here demonstrate the broad application spectrum of FFV-based vectors, especially in pathogen-specific prophylactic and therapeutic vaccination using RD vectors in cats and in classical gene delivery. In the cat-based system, FFV-based vectors provide an advantageous platform to evaluate and optimize the applicability, efficacy and safety of foamy virus (FV) vectors, especially the understudied aspect of FV cell and organ tropism.
Sequence Level Analysis of Recently Duplicated Regions in Soybean [Glycine max (L.) Merr.] Genome

A single recessive gene, rxp, on linkage group (LG) D2 controls bacterial leaf-pustule resistance in soybean. We identified two homoeologous contigs (GmA and GmA′) composed of five bacterial artificial chromosomes (BACs) during the selection of BAC clones around Rxp region. With the recombinant inbred line population from the cross of Pureunkong and Jinpumkong 2, single-nucleotide polymorphism and simple sequence repeat marker genotyping were able to locate GmA′ on LG A1. On the basis of information in the Soybean Breeders Toolbox and our results, parts of LG A1 and LG D2 share duplicated regions. Alignment and annotation revealed that many homoeologous regions contained kinases and proteins related to signal transduction pathway. Interestingly, inserted sequences from GmA and GmA′ had homology with transposase and integrase. Estimation of evolutionary events revealed that speciation of soybean from Medicago and the recent divergence of two soybean homoeologous regions occurred at 60 and 12 million years ago, respectively. Distribution of synonymous substitution patterns, Ks, yielded a first secondary peak (mode Ks = 0.10–0.15) followed by two smaller bulges were displayed between soybean homologous regions. Thus, diploidized paleopolyploidy of soybean genome was again supported by our study.
Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis

Four novel amicoumacins, namely lipoamicoumacins A–D (1–4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.
Ammonits de l'Aptià inferior de la península Ibèrica. Bioestatigrafia i aportacions a l'estudi del Oceanic Anoxic Event 1a

It is now generally accepted that the Oceanic Anoxic Event 1a [OAE 1a] correlates with the lower part of the Leupoldina cabri planktonic foraminiferal Zone. Its calibration against the standard ammonite scale, however, seems to be more problematic. This is due, in part, to the fact that ammonites are scarce and/or of little diagnostic value from a biochronological viewpoint in the lower Aptian pelagic successions where the black shale horizons are better developed. We have been able to characterize OAE 1a geochemically in the relatively shallow water deposits of the eastern Iberian Chain (Maestrat Basin, eastern Spain), where ammonite faunas are rich. The interval corresponding to this event is dominated by the genera Roloboceras and Megatyloceras, accompanied by Deshayesites forbesi and Deshayesites gr. euglyphus/spathi. This assemblage is characteristic of the middle/ upper part of the Deshayesites weissi Zone. The first occurrence of the species Deshayesites deshayesi (d’Orbigny), which marks the base of the overlying zone, takes place in our sections some metres above the OAE 1a interval. In the historical stratotype region of Cassis-La Bédoule (southern Provence Basin, southeastern France), the OAE 1a interval is also characterized by the presence of Roloboceras and Megatyloceras. Nevertheless, it has usually been correlated with the D. deshayesi Zone. In our opinion, this discrepancy is due to divergences in the taxonomic assignments of the deshayesitids present in these beds. In fact, the specimens attributed by French authors [Ropolo, P., Conte, G. , Gonnet, R. , Masse, J.P., Moullade, M. , 2000. Les faunes d’Ammonites du Barrémien supérieur/Aptien inférieur (Bédoulien) dans la région stratotypique de Cassis-La Bédoule (SE France): état des connaissances et propositions pour une zonation par Ammonites du Bédoulien-type. Géologie Méditerranéenne 25, 167–175; Ropolo, P., Moullade, M. , Gonnet, R. , Conte, G. , Tronchetti, G. , 2006. The Deshayesitidae Stoyanov, 1949 (Ammonoidea) of the Aptian historical stratotype region at Cassis-La Bédoule (SE France), Carnets de Géologie / Notebooks on Geology Memoir 2006/01, 1–46. ] to D. deshayesi and D. dechyi can be reinterpreted as belonging to D. forbesi. Following this reinterpretation, the Roloboceras beds (equivalent of OAE 1a) of Cassis-La Bédoule would also correspond to the D. weissi Zone. This age is additionally corroborated by data from southern England [Casey, R. , 1961a. The stratigraphical palaeontology of the Lower Greensand. Palaeontology 3, 487–621; Casey, R. , 1961b. A Monograph of the Ammonoidea of the Lower Greensand, part III. Palaeontographical Society, London, pp. 119–216], and by our recent observations in Le Teil (Ardèche Platform, southeastern France), where the Roloboceras faunas are also associated with Deshayesites consobrinus and Deshayesites gr. euglyphus, taxa that are characteristic of the D. weissi Zone. 2009 Elsevier Ltd. All rights reserved.
Is There a Bank Lending Channel of Monetary Policy in Spain?

This paper uses panel data on banks, for the period 1991-98, to test the existence of a bank-lending channel in the Spanish economy. In order to distinguish between loan demand and supply movements, several exercises are performed. First, we analyse the differential responses, to monetary policy changes, of bank lending by banks with different size, liquidity and capitalisation. Second, we analyse the response to an exogenous deposit-reducing shock a tax-induced shift from deposits to mutual fund shares). As this involves a pure loan supply shock, it best solves the above-mentioned identification problem. Our results are mostly against the existence of a bank-lending channel in the period under analysis. This result appears to be related to the important role of many small banks as collectors of savings, meaning they have a large volume of resources available for lending JEL Classification: C23, E44, E52, G21
An fMRI Investigation of Emotional Engagement in Moral Judgment

The long-standing rationalist tradition in moral psychology emphasizes the role of reason in moral judgment. A more recent trend places increased emphasis on emotion. Although both reason and emotion are likely to play important roles in moral judgment, relatively little is known about their neural correlates, the nature of their interaction, and the factors that modulate their respective behavioral influences in the context of moral judgment. In two functional magnetic resonance imaging (fMRI) studies using moral dilemmas as probes, we apply the methods of cognitive neuroscience to the study of moral judgment. We argue that moral dilemmas vary systematically in the extent to which they engage emotional processing and that these variations in emotional engagement influence moral judgment. These results may shed light on some puzzling patterns in moral judgment observed by contemporary philosophers.
The Muslim presence and representations of Islam among the Meru of Kenya

The thesis analyzes the Muslim presence and representations of Islam among the Meru people of Kenya in the 20th century. The circumstances leading to the establishment of pioneer Muslim communities by the 'Swahili', the Nubians and the Mahaji, in Meru are examined. The rejection or acceptance of Islam by the people of Meru is linked to theories of conversion. The main emphasis is on the local manifestations of Islam. Case material from Meru town and the neighbouring areas is cited. Local representations of Islam and Muslim identity are analyzed in relation to the oppositional dyad of Dini / Ushenzi. The thesis argues that the opposition of Dini to Ushenzi has continuously impinged upon the local manifestation of Islam in Meru. Examples of how this stereotyped notion is transposed from its coastal cultural milieu and applied in a 'fossilized' form by Muslims in Meru are given. The shift in the early 1960s from the previous emphasis on distinctions between the three Muslim groups, to the need for a common Muslim community identity, is linked to the post-independence social-economic crisis that threatened the presence of Islam in Meru. The mechanics of the construction and consolidation of an urban Muslim community identity are examined. The analysis of the internal dynamics of the emergent urban Muslim community focuses on the notion of the propriety of religious practice and behaviour. An examination of the influence of Tabligh during the last decade, (1980- 1990) reveals an increase in the Muslim activities in Meru. Throughout the 1980s Islam spread slowly, almost unobtrusively, in the rural areas in the northern part of Meru. The analysis of the forces underpinning this process; and the resultant dilemma of conflicting identities of individual converts living in the rural areas, is placed within the local social context.
Is There a Patent Troll Problem in the UK?

This paper reports the findings of an empirical study of patent suits involving non-practicing entities (NPEs) in the U.K. between 2000 and 2010. Overall, we find that NPEs are responsible for 11% of all patent suits filed in the U.K. during this period. Though this is a small percentage by U.S. standards, our study suggests that patent trolling might not be as uniquely American as conventional wisdom suggests. We also find little support for many common explanations for Europe’s relative scarcity of NPE activity. For example, we find that NPEs litigating in the U.K. overwhelmingly assert high-tech patents – even more so, in fact, than their U.S. counterparts – despite higher barriers to software patentability in Europe. Our study does, however, tend to support fee-shifting as a key reason for the U.K.’s immunity to NPEs. We see evidence that the U.K.’s loser-pays legal regime deters NPEs from filing suit, while at the same time encouraging accused infringers to defend claims filed against them. U.K. NPE suits are initiated by potential infringers more often than by NPEs; rarely end in settlement; very rarely end in victory for NPEs; and, thus, result in an attorney’s fee award to the potential infringer more often than a damages award or settlement payment to the patentee. Together, these findings tend to support patent reform bills pending in the U.S. that would implement a fee-shifting regime for patent suits, and may also serve to lessen concerns that Europe’s forthcoming Unified Patent Court will draw NPEs to Europe.
Antiprotozoal drugs in the treatment of respiratory allergy: a side that should be explored

Respiratory allergy is one of the most chronic airway diseases and a major health problem worldwide because of its prevalence, considerable impact on quality of life, disproportionate share of healthcare resources and economic burden. Besides factors such as genetic predisposition, environmental contaminants and biological aeroallergens (pollen, fungi, dust mites), the role of certain microorganisms (respiratory viruses such as respiratory syncytial virus and rhinovirus, and atypical bacteria like Mycoplasma pneumoniae and Chlamydophila pneumoniae) on both the development and the severity of respiratory allergy is a subject of continuous debate.
Radio Echo-Sounding of Svalbard Glaciers

Abstract Peculiarities of radio echo-sounding of mountain glaciers and ice fields between nunataks from terrestrial vehicles and from helicopters are considered in this paper. The possibility of using comparatively high frequencies (of up to 865 MHz) for sounding such glaciers is demonstrated on the basis of experimental data. Results of airborne radio echo-sounding of Svalbard glaciers of various types, dimensions, and regime obtained with the help of the 620 MHz airborne equipment of high resolution are shown. Returns from the glacier bed have been obtained on the majority of glaciers under investigation. The firn regions of ice fields with temperate regimes flowing between nunataks are, mostly, an exception. Depression in the glacier bed with the ice thickness up to 540 m, as well as internal reflecting boundaries have been detected in some glaciers. Ice volumes of glaciers have been determined from the airborne radio echo-sounding data with the use of a parabolic approximation to the cross-section glacier profiles. Good correlational dependence between ice volume and surface area of glaciers has been established and is used to estimate the ice and water resources in Svalbard glaciers.
Technologies for foreign language learning: a review of technology types and their effectiveness

This review summarizes evidence for the effectiveness of technology use in foreign language (FL) learning and teaching, with a focus on empirical studies that compare the use of newer technologies with more traditional methods or materials. The review of over 350 studies (including classroom-based technologies, individual study tools, network-based social computing, and mobile and portable devices) revealed that, in spite of an abundance of publications available on the topic of technology use in FL learning and teaching, evidence of efficacy is limited. However, strong support for the claim that technology made a measurable impact in FL learning came from studies on computer-assisted pronunciation training, in particular, automatic speech recognition (ASR). These studies demonstrated that ASR can facilitate the improvement of pronunciation and can provide feedback effectively. Additional studies provided strong support for the use of chat in FL learning. These studies showed that, with chat, both the amount of learners’ language production and its complexity significantly increased. The literature revealed moderate support for claims that technology enhanced learners’ output and interaction, affect and motivation, feedback, and metalinguistic knowledge.
Effects of home-based training with telemonitoring guidance in low to moderate risk patients entering cardiac rehabilitation: short-term results of the FIT@Home study

Background Home-based exercise training in cardiac rehabilitation (CR) has the potential to improve CR uptake, decrease costs and increase self-management skills. The FIT@Home study evaluates home-based CR with telemonitoring guidance using coaching interventions including strategies for behavioural changes with the aim to maintain adherence to a healthy lifestyle and to improve long-term effects. In this interim analysis we provide short-term results on exercise capacity, quality of life and training adherence of the first 50 patients included in the FIT@Home study. Design The study design was a randomised controlled trial. Methods Low to moderate risk CR patients were randomised to a 12-week home-based training (HT) programme or a 12-week centre-based training (CT) programme. In both groups, training was performed at 70–85% of maximal heart rate (HRmax) for 45–60 min, 2–3 times per week. The HT group received three supervised training sessions, before commencing training with a heart rate monitor in their home environment. These patients received individual coaching by telephone weekly, based on training data uploaded on the Internet. The CT programme was performed under the direct supervision of a physical therapist. Exercise capacity and health-related quality of life were assessed at baseline and at 12 weeks. Results CT (n = 25) and HT (n = 25) both showed a significant improvement in peak oxygen uptake (peak VO2) (10% and 14% respectively) and quality of life after 12 weeks of training, without significant between-group differences. The average training intensity of the HT group was 73.3 ± 3.5% of HRmax. Training adherence was similar between groups. Conclusion This analysis shows that HT with telemonitoring guidance has similar short-term effects on exercise capacity and quality of life as CT in CR patients.
Gut Pathogens

While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem. Findings The Gram-positive foodborne pathogen Listeria monocytogenes is a causative agent of gastroenteritis [1] and in severe cases, listeriosis, which ranges from a mild flu-like illness to meningitis in non-pregnant individuals, or as infection of the foetus in pregnant women [2]. Ampicillin, either alone or in combination with gentamicin, remains the gold standard treatment for L. monocytogenes infection [3]. Conversely, cephalosporins are usually poorly active and thus not recommended in the treatment of listeriosis [4,5]. This dissociation in susceptibilities between βlactams has been rationalized by the observation that cephalosporins have poor affinity for PBP3 compared to penicillin, suggesting that PBP3 is the primary lethal target for β-lactams in L. monocytogenes [6]. However, at least five different PBPs have been identified in L. monocytogenes based on their ability to bind radioactive penicillin [6,7]. Moreover, genome analysis revealed seven distinct genes with homologies to PBPs in L. monocytogenes [8]. With the exception of pbpB, each of the remaining genes has been disrupted by insertional mutagenesis [9] without loss of cell viability, suggesting that they are not critically required for normal synthesis of cell wall peptidoglycan. Based on a previous study by Guinane et al., [9] in which an increase in the activity of cephalosporins was observed for L. monocytogenes disrupted in lmo2229 and lmo0441, we investigated the role of their corresponding proteins (PBP4 and Lmo0441 respectively) in protecting the pathogen against a penicillin (ampicillin, AMP), a carbapenem (meropenem, MEM) and a cephalosporin (cefuroxime, CFX). The growth rates for wild-type and mutant strains, together with time profiles for the activity of AMP, MEM and CFX at 100 times their MIC were tested over a 24 h period in TSB broth (Fig. 1, left panel). No significant differences in the growth rates were observed between wild type and both mutant strains. However, this effect is only Published: 15 December 2009 Gut Pathogens 2009, 1:23 doi:10.1186/1757-4749-1-23 Received: 3 December 2009 Accepted: 15 December 2009 This article is available from: http://www.gutpathogens. com/content/1/1/23 © 2009 Van de Velde et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Gut Pathogens 2009, 1:23 http://www.gutpathogens. com/content/1/1/23