Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical Profile and Esophagogastroduodenoscopy Finding in Patients with Acid Peptic Disease at a Tertiary Health Care Centre

Background and Aims: Acid Peptic Diseases (APD) is a common disorder. Population based survey revealed that 44% of the population reported monthly heartburn and 19.8% suffered from heartburn or acid regurgitation at least once a week. An approximate prevalence of 10–20 % was identified for GERD, in the Western world while in Asia this was lower, at less than 5% In this study, we are going to study the clinical features and esophagogastroduodenoscopy (EGD) findings in patients presenting in our centre in order to come to a precise diagnosis and indentify various risk factors contributing to it. Methods and Methodology: 80 patients (53 males, mean age 44 years) were evaluated in the present study after they satisfy the inclusion and exclusion criteria. Patients were posted for endoscopy and findings were tabulated. Results: This age distribution among the 80 patients subjected to EDG over a period of 2 years with maximum i.e., 28.75% was in the 41-50 age groups. The most common symptom at presentation was epigastric pain seen in 84% of patients (67 cases), followed by retrosternal burning sensation seen in 51% of patients (41 cases) and acid reflux seen in 49% of patients (39 cases). A few of the risk factors for APD were evaluated, 34% of study group consumed alcohol, 22.5% were smokers and 19% tobacco chewers. In patients who smoked (total 18) EGD findings was suggestive of severe disease in most of them (14 cases) cases had evidence of severe disease. The combination of smoking and alcohol consumption showed more severe form of disease. Most common finding in endoscopy in esophagus was erosions in seen in 19% of patients, gastritis in stomach 22% and duodenitis seen in 2.5% of cases. Prevalence of GERD was 21% and peptic ulcers were was found in 7.5% of study population. Conclusion: APD is more common in males. Smoking, alcohol and NSAIDS usage is associated with more severe form of APD.
Tick Size Pilot Program and the Information Structure of US Stock Markets

We document significant changes in the relative price discovery of U.S. markets after the implementation of the SEC’s Tick Size Pilot Program (TSPP). Controlling for the volume migration following the TSPP, we find systematic changes in the information share of markets, conditioned on their fee structure. Furthermore, these changes affect institutional trading. Analysis based on intermarket sweep (ISO) and non-sweep orders (NISOs) indicates that informed institutional trading using ISOs are the primary channel through which these changes transpire. These results are important for all studies that examine information propagation in financial markets and include the TSPP sample period.
Mother-offspring conflict for water and its mitigation in the oviparous form of the bimodal lizard Zootoca vivipara

Parent-offspring conflicts are widespread in nature given that resources are often limited. Recent evidence has shown that water can trigger such conflict during pregnancy in viviparous squamate species (lizards and snakes) and thus questions the role of water in the evolution of reproductive modes. Here, we examined the impact of water restriction during gravidity in the oviparous form of the bimodal common lizard (Zootoca vivipara), using the same protocol previously used in the viviparous form. Females were captured in early gravidity from six populations across a 600 m altitudinal gradient to investigate if environmental conditions (altitude, water access and temperature) may exacerbate responses to water restriction. Females were significantly dehydrated after water restriction, irrespective of their reproductive status (gravid vs. non-reproductive), relative reproductive effort (relative clutch mass), and treatment timing (embryonic development stage). Female dehydration together with reproductive performance varied along altitude, likely due to long term acclimation or local adaptation. This moderate waterbased intergenerational conflict in gravid females sharply contrasts to previous findings in the viviparous form, suggesting a potential implication in the reversion from viviparity to oviparity. Therefore, oviparity may constitute a water-saving reproductive mode which might help mitigate intensive temperature-driven population extinctions at low altitudes.
A study of the relationship between lifestyle and happiness of students at Kermanshah University of Medical Sciences over 2015–2016

Background: Lifestyle, as one's behavior patterns, greatly affects one's health and society. In addition, happiness is seen as one of the major mental needs of human beings. When happiness is addressed in relation to university students, as the vibrant strata of societies, its significance becomes twofold. Objective: The present study aimed to investigate the relationship between the lifestyle and happiness of students at Kermanshah University of Medical Sciences between 2015 and 2016. Materials and Methods: In this descriptive and correlational study, the statistical population comprised all students at Kermanshah University of Medical Sciences in the 2015–2016 academic year, of which 600 students (210 males and 224 females) were selected through the stratified random sampling. Further, for data collection, the lifestyle questionnaire and Argyle's revised Oxford happiness questionnaire were utilized. Then, data were analyzed through the descriptive and inferential statistics in the SPSS Statistics Software version 21.0 (P < 0.05). Results: In the present study, the mean scores of lifestyle and happiness measured 13.0 ± 50.2 and 0.25 ± 39.3, respectively. Furthermore, the results of the Pearson product-moment correlation coefficient revealed that there was a significant positive relationship between the university students' lifestyle and happiness (r = 0.631, 0.38). Conclusions: The bilateral relationship between lifestyle and happiness and their effects on the overall health is a topic that should be discussed in issues pertaining to health. Given the relationship between the variables of the present study, to boost the students' lifestyles toward improving their happiness, it is recommended that careful plans should be laid by the cultural departments in collaboration with the counseling centers in universities through providing various packages in the form of classes and workshops.
Depression and influencing factor in pregnancy: A community-based study -

Background: Pregnancy is a term in which significant biological and psychosocial changes in womenâ€™s lives are experienced, and there is a high risk of encountering many anxieties and stresses. Objectives: The objective of the study is to estimate the prevalence and risk factors for pregnancy in Eastern Turkey in ElazA½g. Materials and Methods: A community-based, cross-sectional, and descriptive study was conducted in the primary health-care center in ElazA½A° (pregnant women population: 4855). A total of 240 pregnant women were included in the study. The questionnaires were applied to pregnant women by visiting home. Each participant completed a questionnaire and the Beck Depression Inventory. The data were analyzed in SPSS version 18.0. One-way ANOVA and t-test analyses were used in the statistical evaluation. Results: The mean age of the women was 26.78 Â± 5.52. About 7.1% of pregnancies are in terms of adolescence. About 11.7% of the women are not knowing literacy. The rate of women who have got the level of low economic is 81.7%. The average of marry age of women is 20.97 Â± 4.34. About 20% of women who are involved in research are in the first trimester, and 23.3% of women are in the second trimester. About 25.4% of women have not planned pregnancy. The rate of pregnancy who take antenatal care is 92.5%. BDS average is found out 14.97 Â± 8.58. Although the score of the Beck Depression Scale of adolescence pregnancy old is 17.71 Â± 8.26, pregnant women of afterward and 35 years are 17.92 Â± 11.56 (P = 0.06). While the score of Beck Depression Scale of illiterate pregnancy is 20.93 Â± 9.03, literate pregnancy is found 16.33 Â± 6.54 (P = 0.0001). The average depression score of pregnant women who talk to their husband about their problem is found out 14.31 Â± 8.76 and 17.08 Â± 8.65 by mother (P = 0.000). While average of the Beck Depression Scale of women who first pregnancy is 13.51 Â± 8.51, an average of depression of women who two or upper pregnancy is found out 15.82 Â± 8.54 (P = 0.045). Beck depression scale score is significantly decrease in women who her husband low level of education, term of last pregnant be between 3 and 6 years, have a health problem in during her pregnancy, non-antenatal care. Conclusion: Pregnant women had middle levels of depression which were associated with some sociodemographic variables. When pregnant women are medically examined, a holistic approach should be made to pregnant women.
Diagnostic Value of Bronchoscopy for Peripheral Metastatic Lung Tumors

Simple Summary Metastatic lung tumors are relatively common, and their pathological diagnosis is crucial for determining the appropriate treatment strategy. Although bronchoscopy is one biopsy method, its role has not been established for peripheral metastatic lung tumors. The present study aimed to investigate the value of bronchoscopy, using radial endobronchial ultrasound for diagnosis. We analyzed 235 lesions consecutively, and the overall diagnostic yield was 76.6%, which was slightly higher than the reported cumulative sensitivity for general peripheral pulmonary lesions. There were no serious complications. The results demonstrated that bronchoscopy is a valuable technique for peripheral metastatic lung tumors that combines diagnostic accuracy and safety. Moreover, the higher diagnostic yield was associated with the large lesion size, inner location, and visibility on radiography. These findings should contribute to the selection of biopsy methods for metastatic lung tumors and improve the diagnostic yield. Abstract Although lungs are one of the most frequent sites of metastasis for malignant tumors, little has been reported about the value of bronchoscopy for lung metastases presenting with peripheral pulmonary lesions (PPLs). This retrospective cohort study investigated the diagnostic value of bronchoscopy for peripheral metastatic lung tumors. Consecutive patients who underwent diagnostic bronchoscopy with radial endobronchial ultrasound for PPLs and were finally diagnosed with metastatic lung tumors from April 2012 to March 2019 were included. We analyzed 235 PPLs, with a median size of 18.8 mm. The overall diagnostic yield was 76.6%. In a multivariable analysis, large lesion size (>20.0 mm vs. <20.0 mm: 87.6% vs. 67.7%, p = 0.043, OR = 2.26), inner location (inner 2/3 vs. outer 1/3: 84.8% vs. 69.1%, p = 0.004, OR = 2.79), and visibility on radiography (visible vs. invisible: 83.2% vs. 56.1%, p = 0.015, OR = 3.29) significantly affected the diagnostic yield. Although a positive bronchus sign tended to have a higher yield, no significant difference was observed (81.8% vs. 70.6%, p = 0.063). Only one case of lung abscess was observed, with no serious complications. In conclusion, bronchoscopy is a valuable technique for peripheral metastatic lung tumors, with good diagnostic accuracy and safety.
Optimized Single Carrier Transceiver for Future Sub-TeraHertz Applications

The performance of sub-THz communications, contemplated for the next generation of wireless networks, are significantly degraded by oscillator phase noise. In this paper, we address the design of a single carrier transceiver resilient to phase noise. This problem is treated in two steps: First, we derive for phase noise channels the optimum symbol detection criterion. Second, we propose a phase noise robust modulation scheme with a comprehensive and efficient structure. System level simulations modeling the sub-THz propagation channel of a rich outdoor environment through ray tracing are also presented. Results show that optimizing the modulation and demodulation schemes is necessary to achieve high spectral efficiency in the presence of phase noise.
Aviscumine (ME-503)-Skin Reaction as significant Factor for its Efficacy Expanded Evaluation of the Results from the Phase II Trial NCT00658437 in Patients with Unresectable stage IV Metastatic Melanoma

Aviscumine (ME-503), a recombinant lectin, enhances inflammatory cytokine (esp. IL-1β) release, activation of Langerhans cells, and T-cell responses. An extended evaluation of phase II data of the patient cohorts with/without skin reactions within the first treatment cycle after SC injection regarding the efficacy of aviscumine are presented. 31 patients (ITT total population) (ECOG: 0 or 1) with progressive stage IV malignant melanoma after failure of standard therapy were enrolled onto a single-arm, multi-centre, open-label, phase II trial (NCT00658437). Patients received 350 ng aviscumine twice weekly by SC injection until progression. Tumor response was assessed every eight weeks, survival of patients was followed up to one year after the end of therapy. 21 patients with skin reactions vs. 9 patients without skin reactions as adverse events were assessed for efficacy in an expanded evaluation. Comparing the median overall survival data (mOS) in patients (n=9) without injection site reactions (mOS: 5.1 months; 95% CI 2.1-6.9; 1-year survival rate: 0%) with survival data in patients (n=21) showing injection site reactions (mOS: 14.6 months; 95% CI 11.0-19.8; 1-year survival rate: 62%) a clear difference in favor of the patients with skin reactions is seen. The difference in overall survival between these two groups of patients was high significant (p<0.0001). In the total ITT population (n=31) the mOS was 11.0 months (95% CI 6.9-19.8) and the 1- year survival rate was 45%. Preliminary conclusions from our small cohorts suggest a strong clinical impact of aviscumine in patients with previously treated metastatic melanoma if those patients show injection site reactions as adverse events after SC injection within the first treatment cycle. Patients without any injection site reactions apparently failed to prove clinical benefit.
Personalized Outreach to University Students With a History of Reading Difficulties: Early Screening and Outreach to Support Academically At-Risk Students

Abstract: We examined whether identification of and personalized outreach to a group of students with a history of reading difficulties would impact their use of support services and academic outcomes. Using a brief self-report questionnaire, we identified students with a history of reading difficulties (n = 175) and a comparison group of university students without a history of reading difficulties (n = 100). One half of the students with a history of reading difficulties were individually invited to visit the Academic Advising Centre; the other students received standard university communications about and access to university support services. Students with a history of reading difficulties who received personalized outreach in the first semester of their studies were more likely to use the Academic Advising Centre both in the weeks directly following outreach and in their second year of study. Outreach also increased use of the Study Skills Centre, but not the Writing Centre. Further, there was evidence of a positive effect of personalized outreach on the number of credits earned. Finally, the effect of first-semester personalized outreach on use of Academic Advising Centre in the second year was especially prominent for students who experienced serious academic difficulties in their first year. Overall, our results show promising outcomes for a simple, proactive, cost-effective approach to identify and provide personalized outreach to academically at-risk students.
Cord blood bilirubin level as a predictor of development of pathological hyperbilirubinemia in new-borns

Neonatal hyperbilirubinemia is usually a benign condition observed during the first week of life in approximately 60% of term infants and 80% of preterm infants. Although most cases are physiological, it is imperative to identify those at risk of adverse outcomes of severe neonatal hyperbilirubinemia to initiate early therapy so as to prevent long term morbidity. Although bilirubin may have a role as an anti-oxidant, elevations of unconjugated bilirubin are potentially neurotoxic. The potential risk of developing bilirubin encephalopathy or even kernicterus is high in babies with elevated serum bilirubin level. The sequelae could be serious as patients may develop cerebral palsy, sensorineural deafness and mental retardation.
Effect of Zinc applications on Grain Yield, Straw Yield and Harvest Index in kharif Rice (Oryza sativa L.) Genotypes

Rice (Oryza sativa L.) remains the staple food for nearly half the world‟s population, most of them living in Asia, and many of them among the poorest people in the world (Fischer 1998). In Asia, rice is the premier food crop and foremost cereal and therefore, food security largely depends on productivity of the rice ecosystem. India is first in terms of area (43.79 mha) and second in production (168.50 mt) of paddy, next only to China. However, the average productivity of paddy in India is only (3.85 t ha -1 ) compared with a world average of 4.60 t ha -1 , still well below the world average, although increasingly marginally (FAO 2017). Micronutrient deficiencies are becoming serious because of International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 11 (2019) Journal homepage: http://www.ijcmas. com
Phase I Trial of the Oral Poly (ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888, V) Combined Wtih Topoecan (T) and Carboplatin (C) for Adults with Relapsed and Refractory Acute Leukemias,

Abstract 3276 PARP is activated in response to DNA single strand (SS) breaks and is pivotal to the base excisional repair pathway for chemotherapy-damaged DNA. The orally bioavailable PARP inhibitor V delays DNA repair and potentiates the cytotoxicity of multiple classes of chemotherapy drugs including topoisomerase I inhibitors and platinating agents in leukemia cell lines. A previous clinical trial of T+C yielded promising results in adults with refractory acute leukemia at the maximum tolerated dose (MTD) of T 1.6 mg/m 2 /d + C 150 mg/m 2 /d by intravenous continuous infusion (IVCI) × 120 hrs. We are conducting a Phase I dose-escalation trial of V given orally twice daily Days 1–8 with T+C given by 120 hr IVCI Days 3–7. Deaths due to myocardial infarct and splenic infarcts with ascites occurred in one pt each when C 150 mg/m 2 was added to V 10 mg BID and T 1.3 mg/m 2 , resulting in adjustment of the dose escalation schema for C and T. Of 27 pts treated at doses of V 10–20 mg orally BID Days1-8 and T 1.0–1.2 mg/m 2 /d + C 120–150 mg/m 2 /d for 120 hrs IVCI Days 3–7, 8 (30%) have experienced > grade 3 non-hematologic toxicity, 4 (15%) have had grade 4 toxicity and 1 (4%) died from sepsis with multi-organ failure. Overall response rate is 22% (2 CR, 1 CRi, 3 PR), with 4 in relapsed AML, 1 each in refractory AML and refractory ALL. Pharmacokinetic (PK) studies in pt plasma, marrow supernatant, and marrow blasts demonstrated that V does not accumulate with multiple dose administrations in plasma but does in marrow, is not altered by T or C administration, and is detectable in marrow supernatant and cells. Nuclear staining for phosphorylated histone H2AX (γH2AX) demonstrated that V 10 mg BID increased DNA damage by > 2-fold in 11/22 (50%) on Day 1 and 13/18 (72 %) on Day 4 after 24 hrs of T+C. A PAR ELISA demonstrated that V suppresses PAR levels to Disclosures: No relevant conflicts of interest to declare.
Examining Parent Information Needs in Pediatric Cancer

Parents of children with cancer receive information about how to care for their child's health during diagnosis, treatment, and post treatment inflation is critical to this care; however, parents are often left with information needs when their child is done with treatment. Many parents lack enough information about neurocognitive late effects (NCLE) and how to handle the psychological functioning of their child post treatment. The purpose of this study was to analyze parents' information needs post treatment using qualitative data collected from a survey. Qualitative content analysis was utilized to examine 45 parent responses. Four themes were constructed: (a} the long-term impact of the survivor's cancer treatment; (b) concerns about the mental and physical functioning of the survivor; (c) parent and family functioning; (d} and accessing information and help. Parents had greater need for information related to the theme of long-term impact of the survivor's cancer treatment, specifically relating to the long-term effects of treatment/NCLE/late effects, their concerns about the psychological and emotional functioning of the survivor, and their concerns about the survivor becoming an independent adult. Results showed that parents need more information provided to them by healthcare professionals (HCPs) about NCLE, the psychological and emotional functioning of the survivor, and where to access resources on issues post treatment. Degree Type Open Access Senior Honors Thesis Department Psychology First Advisor Catherine Peterson Second Advisor Natalie Dove
Precision Constraints during Pointing with a Stylus: Implications for Fitts’ Law

Previous research on performance on the Fitts pointing task has identified the relative influences of task and effector constraints. Effector constraints are those specific to the motor and physical aspects of the task, such as movement distance, which tend to affect the overall duration of the movement. Task constraints, such as target size, affect the underlying movement dynamic, with effects isolated to the end of the movement, causing asymmetry in the velocity profile. Here, evidence confirming these effects is reported, along with a new task constraint, target size as defined as a physical constraint on final positioning error. A new formulation of Fitts’ law is presented that accounts for all constraints.
What supports the deep chlorophyll maximum in acidic lakes? The role of the bacterial CO2 production in the hypolimnion

The interactions between phytoplankton, bacteria and resources, irradiance, and nutrients, leading to the formation of deep chlorophyll maxima (DCMs), are little understood in acid lakes. In “El Sancho” reservoir (Iberian Pyritic belt, Huelva, Spain), an acid mine drainage impacted waterbody (pH 3.5–4.0), a strong DCM forms in the metalimnion during the stratification period. The DCM was located always below the 1% irradiance level, where the decreasing irradiance profile overlapped with a dissolved inorganic carbon concentration (CO2) gradient decreasing upward from the hypolimnion. The DCM was dominated by the chlorophyte Carteria sp. and showed the highest volumetric photosynthetic and dark respiration rates. The DCM, however, only contributed around 20% of water column integrated gross primary production, while it accounted for 54–66% of water column chlorophyll. The total bacterial abundance correlated significantly with the CO2 concentration (r = 0.74). To test the hypothesis of a possible dependence of the formation of the DCM in acid lakes on the production of CO2 by heterotrophic bacteria, a one‐dimensional reactive transport model (DCM‐CO2) was developed and tested. The DCM‐CO2 model simulated the vertical distribution of chlorophyll (R2 > 0.63) and the vertical profile of CO2 rather accurately (R2 > 0.79), the position of DCM depending on both light penetration and an upward flux of CO2 produced by hypolimnetic heterotrophic bacteria. Overall, the results support the hypothesis of microbial degradation of organic matter being a source of CO2 for acid lake primary producers at the DCM.