Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

Significance The oncoprotein transcription factor MYC is a validated but challenging anticancer target. In this work, we show that WDR5—a well-structured protein with druggable pockets—could be a focal point for effective anti-MYC therapies. We demonstrate that WDR5 recruits MYC to chromatin to control the expression of genes connected to protein synthesis, a process that is arguably deregulated in all cancers. We also show that disrupting the interaction between MYC and WDR5 causes existing tumors to regress. These findings raise the possibility that the MYC–WDR5 nexus could be targeted to treat cancer. The oncoprotein transcription factor MYC is overexpressed in the majority of cancers. Key to its oncogenic activity is the ability of MYC to regulate gene expression patterns that drive and maintain the malignant state. MYC is also considered a validated anticancer target, but efforts to pharmacologically inhibit MYC have failed. The dependence of MYC on cofactors creates opportunities for therapeutic intervention, but for any cofactor this requires structural understanding of how the cofactor interacts with MYC, knowledge of the role it plays in MYC function, and demonstration that disrupting the cofactor interaction will cause existing cancers to regress. One cofactor for which structural information is available is WDR5, which interacts with MYC to facilitate its recruitment to chromatin. To explore whether disruption of the MYC–WDR5 interaction could potentially become a viable anticancer strategy, we developed a Burkitt's lymphoma system that allows replacement of wild-type MYC for mutants that are defective for WDR5 binding or all known nuclear MYC functions. Using this system, we show that WDR5 recruits MYC to chromatin to control the expression of genes linked to biomass accumulation. We further show that disrupting the MYC–WDR5 interaction within the context of an existing cancer promotes rapid and comprehensive tumor regression in vivo. These observations connect WDR5 to a core tumorigenic function of MYC and establish that, if a therapeutic window can be established, MYC–WDR5 inhibitors could be developed as anticancer agents.
Images of Women in High School EFL Textbooks

Gender inequalities still exist and in more complex ways than before in Japanese society (“Fighting Unfairness,” 2002). As for gender issues in EFL education, Sunderland (2000) argues for the importance of increasing gender awareness among language professionals by investigating EFL textbooks. Moreover, Ferguson (1986) indicates that the images in stories reflect the reality which readers face in everyday life and influence their thoughts and conduct on a daily basis. It is important therefore to be aware of the images of women shown in stories when we consider developing Japanese EFL textbooks.
Intracranial pressure modulates aqueous humour dynamics of the eye

An elevation in intracranial pressure (ICP) lowers conventional outflow facility (increases aqueous outflow resistance) of rat eyes. The reduction in outflow facility correlates with an increase in intraocular pressure (IOP). The effect of ICP elevation on outflow facility and IOP is blocked by TTX. The results indicate that aqueous humour dynamics is modulated by ICP‐driven neural feedback from the brain. This feedback mechanism may act to stabilize translaminar pressure across the optic nerve head and may provide a new avenue for glaucoma therapy.
Who Becomes More Productive?: A Model of Endogenous Sectoral Choice with Costly External Finance∗

Abstract Cross-country data shows a positive correlation between a nation’s contract enforcement level and its ability to adopt modern technologies. I study the role entrepreneurial incentives play in shaping this empirical observation. I develop and solve a life-cycle model with limited financial contract enforcement, entrepreneurial heterogeneity (ability and financial pledgeability) and technology choice. In the model production processes can be undertaken using either the Traditional or the Modern technology. Depending on the entrepreneurial ability, the modern technology can be more productive relative to the traditional technology, but the former requires a long-term investment making entrepreneur’s pledgeability important in his choice. In equilibrium the level of contract enforcement and entrepreneurial characteristics endogenously determine (1) the investment size and (2) the technology choice. Key results of the paper indicate that when financial contract enforcement is weak, the investment size and the intensity of modern technology use of entrepreneurial firms are positively correlated with financial pledgeability. Collateral-building associated with short term investment is important for the results. I calibrate the model to study its quantitative properties. Quantitative experiments illustrate sizeable positive effects of financial contract enforcement on aggregate output and aggregate modern technology adoption for the U.S. economy. Furthermore, counterfactual analysis shows that if financial contract enforcement in Turkey (a low enforcement economy) improves to the U.S. level (a high enforcement economy), output rises by 13-15%; and one third of this change is due to the increase in the rate of modern technology adoption.
C O ] 2 4 N ov 2 01 9 Linear mappings preserving the copositive cone

Let Sn be the set of all n-by-n symmetric real matrices, and let Cn be the copositive cone, that is, the set of all matrices a ∈ Sn that fulfill the condition uau > 0 for all n-vectors u with nonnegative entries. We prove that a linear mapping φ : Sn → Sn satisfies φ(Cn) = Cn if and only if φ(x) = mxm for a fixed monomial matrix m with nonnegative entries.
Rhizobia Inoculants for Alfalfa in Acid Soils: A Proposal for Uruguay

Tabares-da Rosa S1 , Signorelli S1 , Del Papa M2 , Sabatini O1 , Reyno R3 , Lattanzi F3 , Rebuffo M3 , Sanjuán J4 , Monza J1 1 Laboratorio de Bioquímica, Depto. Biología Vegetal, Facultad de Agronomía, Universidad de la República, Uruguay. 2 Instituto de Biotecnología y Biología Molecular, Facultad de Ciencias Exactas, Universidad Nacional de la Plata, Argentina. 3 Instituto Nacional de Investigación Agropecuaria, INIA La Estanzuela e INIA Tacuarembó, Uruguay. 4 Depto. de Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas (CSIC), Granada, España.
National innovation policies , innovation actors and firm innovation performance in India

Innovation output by a firm is essential for gaining competitive advantage over its competitors in any sector or industry, particularly in the present era of open innovation. Based on the data of 707 Indian enterprises during the period 2010-2012, the present study explores the effect of government innovation support policies and external collaborative efforts on the innovation outcome in the form of patent applications of firms based on the National Innovation System (NIS) and Resource-based-View (RBV) approaches using the technique of count data model. The findings show that there is significant positive relationship between inter-firm collaborations, cooperation with universities and research organisations and innovation performance of enterprises, of which the international partnerships are more stronger than the domestic collaborations in the Indian context. Firm’s internal capabilities in the form of training and up-gradation of the skill of human resources have a positive influence on external innovative collaborations and innovation outputs. The results also indicate the significance of government innovation support in fostering the firm’s collaboration with international research universities and organisations as well as international firms in demonstrating significant impact on the patenting activities of the enterprises.
UNIVERSITY OF FLORIDA THESIS OR DISSERTATION FORMATTING TEMPLATE

of Thesis Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Master of Science CHARACTERIZATION OF ARSENIC RESISTANT BACTERIAL COMMUNITIES IN THE RHIZOSPHERE OF AN ARSENIC HYPERACCUMULATOR Pteris vittata L. By Anhui Huang May 2009 Chair: Lena Q. Ma Cochair: Max Teplitski Major: Soil and Water Science The arsenic (As) hyperaccumulator fern Pteris vittata L. produces large amounts of root exudates, which are hypothesized to solubilize arsenic and maintain a unique rhizosphere microbial community. A group of rhizosphere arsenic resistant bacteria were isolated and identified from two arsenic-contaminated sites where P. vittata growed. Twelve aerobic or facultative anaerobic bacterial isolates (Naxibacter sp. AH4, Mesorhizobium sp. AH5, Methylobacterium sp. AH6, Enterobacter sp. AH10, Pseudomonas sp. AH21, AH34, AH43, AH45, Bacillus sp. AH22, Acinetobacter sp. AH23 and Caryophanon sp. AH28) were resistant to 400 mM arsenic, the highest level of arsenic resistance reported to date. Two levels of arsenic detoxifications were proposed and studied. General resistance mechanisms were investigated by studying microbial growth characteristics under osmotic /oxidative stresses induced by sodium arsenate, sodium chloride, polyethylene glycol 6000 (PEG6000), or hydrogen peroxide. Arsenic specific resistant mechanisms were determined by identifying the two functional arsC or arrA genes based on PCR and Southern Hybridization method. Similar hydrogen peroxide inhibitions with broad-host pathogen Salmonella typhimurium were observed, and bacteria grew better
Stability of Microstructure in Al3003 Builds made by Very High Power Ultrasonic Additive Manufacturing

Very High Power Ultrasonic Additive Manufacturing (VHP-UAM) system was used to produce aluminum parts from 150 μm thick Al3003-H18 foils. The build was processed at 36 μm vibration amplitude, 8 kN normal load, and 35.6 mm/s weld speed at 20 kHz frequency. Almost 100% linear weld density was achieved. A deformation-interaction volume of ~20 μm was observed below the bonded interface. The microstructural stability including grain boundary structures, and crystallographic orientations was evaluated after annealing these samples at 343 o C for 2 hours and 450 o C for 2 hours. After heat treatment, small grains persisted at the interfaces with sluggish grain growth kinetics. In contrast, normal grain growth kinetics was observed in the middle of the foils. Possible mechanisms for such phenomena are discussed.
Service quality, customer satisfaction and customer loyalty: A study with special reference to indian banking industries

The purpose of the research article is to examine effect of service quality and customer satisfaction on customer loyalty among the group of customers in Indian banking industries. Data has been collected from 298 customers of the Indian banking industries; this study is cross sectional and descriptive in nature. With the help of the result of the study we can say that customer satisfaction is significantly and positively related with customer loyalty customer satisfaction is also to be found important mediator between service quality and customer loyalty. In the last of the study we also have discussed that banking service provider follow right course of action to win customer satisfaction by providing better service quality in order to create loyal customer base.
DECADAL EVOLUTION OF TIDAL CHANNEL HYPSOMETRY IN THE OUTER WESER ESTUARY, GERMANY

This study focuses on the morphodynamics of the Fed derwarder Priel tidal channel, located in the Outer W ser estuary (German Bight). Tidal channels and adjacent flats ar e highly dynamic systems whose morphologic evolutio n is mainly driven by tidal and wind forcings. These coastal sy stems react to changing hydrodynamic conditions in various time and length scales. Annual digital elevation models are available covering the time period from 1998 to 2016. We used hypsometries and vertical dynamic trends to analyze and visualize the morphologic evolution of the Fed d rwarder Priel and adjacent tidal channels. Besides evaluating the applied methods sediment accumulation on intertidal flats was assessed. The findings indicate that tidal flats ac crete with a rate exceeding sea level rise. Results are discussed with respect to further studies in the German Bight.
Relationship between Exercise Intensity Prescription Indexes in Diplegia Spastic Patients during Cycling

the American College of Sport Medicine (ACSM) assumes that a percentage of heart rate reserve (%HRR) provides the same intensity as the equivalent percentage of maximal oxygen uptake (VO2Max). Recently studies demonstrated that some factors particularly kind of disease are influenced the relationship between exercise intensity indexes. Objective: The purpose of this study was to determine relationship between exercise intensity indexes (%HRR, %VO2Max, %VO2Reserve) in children with diplegic spastic cerebral palsy during ergometer submaximal test. Method: The subjects consisted of 25 individuals with spastic cerebral palsy (ages , 9-14 years) that participated by voluntarily in study. For each subject, HR and VO2 at rest and at the end of each stage of exercise and at the end of exercise determined using Macmaster ergometery protocol that is submaximal and specific for children and used of those for calculation exercise intensity indexes. The correlation between this indexs determaind via statical SPSS. Results: The results of study showed that %VO2Max is correspond to %VO2Reserve in each stage of ergometery protecol (r =0.99) and the correlation between the other indexes is lower. Conclusion: The data showed that for prescription exercise-rehabilitation program in spastic cerebral palsy patients, %VO2reserve and %VO2max are similar and relation between exercise intensity indexes in children with spastic cerebral palsy is different to findings in the other patients and normal elderly.
gpusat2 – An Improved GPU Model Counter

In this paper, we present and evaluate a new parallel propositional model counter, called gpusat2, which is based on dynamic programming (DP) on tree decompositions using log-counters. gpusat2 implements the principle of single instructions on multiple threads (SIMT) for parallel programming on a GPU using the vendor-independent programming framework OpenCL. We introduce a novel architecture that includes variable data storages and compressing solution parts. We outline results to experiments where we compare the runtime of our system with stateof-the-art model counters on standard benchmark sets for model counting. In particular, we test also other parallel solvers and the predecessor of gpusat2. One major outcome is that the novel architecture significantly improves our solver over its predecessor. As a side result, we observe that state-of-the-art preprocessors allow to produce tree decompositions of significantly smaller width.
AN AUDIENCE PARTICIPATION ANGRY BIRDS PLATFORM FOR SOCIAL WELL-BEING

In this paper, we design an audience participation Angry Birds platform and evaluate its effectiveness in promoting social well-being. Existing work reported that playing online games together with other players has positive effects on the promotion of communication and improvement of social relations. With the advent of audience participation games, research on methods for cooperative operations is gaining attention. However, in games targeted in existing research, game rules are complicated, so audiences need time to learn how to play them. Therefore, we focus on the Angry Birds game with simple rules and propose a mechanism to let audiences control bird shots via chat. In addition, the maps, levels, or stages of those games in the existing audienceparticipation-game studies are fixed, so such games may become boring and make the audience give up playing. Therefore, we also propose another mechanism to let audiences generate original game levels via chat, which is expected to increase fun. Our results confirm the effectiveness of both proposed mechanisms.
Depinning transition in failure of inhomogeneous brittle materials by Laurent Ponson

As is by now well known, disorder and interactions give birth to qualitatively new phenomena and a rich phenomenology. For example, random interactions in disordered magnets can lead to a true thermodynamic spin-glass phase where long-ranged amorphous order sets in – i.e., there is long range order, but without any obvious broken symmetry. The dynamics also shows characteristic features: slow relaxation, aging, and intermittency, i.e. long stases in deep metastable states separated by sudden jumps. Similar effects also take place for elastic systems embedded in a material containing random impurities, such as vortex lines, domain walls or charge density waves. Here again, the low temperature phase can be qualitatively different from its “pure” (no disorder) counterpart; these objects can be macroscopically pinned by disorder, in the sense that a small external force F is not sufficient to set them into motion; the linear mobility is zero. The external drive must be large enough to depin these systems and allow them to “flow”; at zero temperature there is a well defined depinning threshold Fc, characterized by a diverging correlation length, critical exponents, etc. that have been described with exquisite details within the Functional Renormalisation Group [1,2]. Around the transition, the dynamics is again intermittent: nothing happens for a while before patches of the system unlock, triggering “avalanches” of all sizes. At finite temperature, the transition is smoothed by activated events; the system acquires a finite velocity even below the critical force, but in this so called “creep” regime, the velocity is exponentially small.
WST 50.8 EEAT-22 corr

This research has been conducted based on the fact that acetic and butyric acids are favorable substrates for methanogens, and that a low level of propionic acid production during acidogenesis minimizes the inhibition effect on methanogenic growth. Raw swine wastewater was pretreated with ammonia stripping to enhance acidogenesis. The ammonia nitrogen concentration of less than 1.2 g/L did not significantly affect the biochemical acidogenic potential of swine wastewater. For acidogenesis of swine wastewater, a set of experiments were carried out to produce short chain volatile fatty acids (VFA) in laboratory-scale continuously stirred tank reactors. The production of acetic, propionic, and butyric acids associated with simultaneous changes in hydraulic retention time (HRT) and temperature was investigated. Response surface methodology was successfully applied to approximate the responses of the VFA productions. The optimum physiological conditions where the maximum acetic and butyric acids production occurred were 2.4 days HRT at 34°C and 2.1 days HRT at 35°C, respectively. The propionic acid production linearly increased as both HRT and temperature increased.
Expectations-Based Loss Aversion May Help Explain Seemingly Dominated Choices in Strategy-Proof Mechanisms

Deferred acceptance (DA), a widely implemented algorithm, is meant to improve allocations: under classical preferences, it induces preference-concordant rankings. However, recent evidence shows that—in both real, large-stakes applications and experiments—participants frequently play seemingly dominated, significantly costly strategies that avoid small chances of good outcomes. We show theoretically why, with expectations-based loss aversion, this behavior may be partly intentional. Reanalyzing existing experimental data on random serial dictatorship (a restriction of DA), we show that such reference-dependent preferences, with a degree and distribution of loss aversion that explain common levels of risk aversion elsewhere, fit the data better than no-loss-aversion preferences. (JEL D11, D82, D91)
Think globally and act locally-Textbooks

Coursebooks still lie at the heart of English language teaching and the number of them is increasing dramatically every year. In spite of an array of published material available, it can be an extremely challenging task to choose the right material. And this particularly applies to a novice teacher. Given the fact that the vast majority of current teaching and learning materials are primarily intended and produced for the global market, the commercial materials cannot cater for such variables as different types of learners of various backgrounds, origins, interests, levels of proficiency. As a result, we, teachers, are forced to make informed judgments about the choice of materials. Additionally, we are almost invariably made to question the extent to which we should adapt the materials. In the light of the environmental slogan think globally and act locally, the paper sets out to make a contribution to this topical and everyday issue, and attempts to look at some considerations in order to make our teaching more student-centred, effective as well as more enjoyable.
Assessment of Genetic Variability in Introduced and Indonesian Soybean Genotypes Using Morphological and SNAP Markers

Genetic variability of 66 soybean (Glycine max (L.) Merril) genotypes comprising 25 improved varieties from Indonesia and 41 introduced genotypes was estimated using ten Single Nucleotide Amplified Polymorphism (SNAP) markers to complement the morphological characters searched from public domain. A number of quantitative morphological characters (plant height, seed weight and yield) showed high variations (CV>20%), while the diversity of qualitative morphological characters was relatively moderate (0.25-0.50). Yield was strongly correlated with seed weight, but moderately correlated with oil content. Eigen values indicated the highest variation on stem determination, flower color, seed coat color, plant height, seed weight, protein content, oil content and yield, suggesting their contribution as selection descriptors. Indonesian improved varieties less varied than introduced genotypes according to the morphology. The relationship among genotypes according to morphological characters was not relevant with the origin. The dendrogram constructed based on genetic similarity among 66 genotypes using SNAP identified four main clusters with a cut off of 0.59. Indonesian improved varieties were more narrow their genetic than introduced genotypes. Indonesian improved varieties were closer to genotypes from East Asia than those from United States, indicating their origin relation. Notably, phylogenetic analysis based on SNAP markers confirmed clearer separation than morphological characters. This information could be useful for efficient identification of genotypes and selection in the future soybean breeding in Indonesia.
Corpus Linguistics and Linguistic Theory

Lakoff (2002 [1996], Moral politics. How liberals and conservative think. Chicago: The University of Chicago Press) presents the Theory of Moral Politics (TMR), as based in the roles of metaphor in moral thinking in American Politics. Two distinct methods of data analysis, one social-psychological and one cognitive-linguistic, have been employed to empirically test Lakoff’s assertions on moral reasoning, but have yielded different results. We applied both methods to the same corpus of speeches to determine whether they would yield similar results and could thus be considered to be equally appropriate ways of testing the presence of moral language. We show that the method affects what sort of conclusion can be drawn from research. Consequently, when testing TMR, we recommend that the corpus-linguistic method used is critically evaluated.