Miracle-dz/UniFAR-FTUs huggingface dataset:
Mobile Phones; A Boon or Bane for Mankind? - Behavior of Medical Students

As the science develops new innovations as well as new products come for the comfort and help of mankind to lesser physical and mental labor and input efforts for a particular task. One of the good examples is calculator and other is mobile phone, they help us to this extent that somehow we become dependent on both of them and to a larger extent on mobile phones. Today this is difficult to think a life without a mobile phone because this is not only a phone but also a calculator, camera, computer, email, store house of information, play station and a lovely music system too. These reasons are enough compelling to have and use mobile phones in our day to day life for any gender or age. This usage of mobile phone is increasing day by day in numbers as well as in per hour per person usage too. This too much or unusual use or unsafe usage has become some sort of psychological and physical dependence to an extent of addiction lending in behavioral changes. This is dual sword. As a good citizen, we are in a position to analyze whether the science and technology like mobile is doing good to human beings or it harms if, so on what cost? mobile is lifeline in hands of health care professionals, aa need in emergency to anyone, plumber,electrician, laundry, food and catering services all are just a phone call away but misuses are also many like small time to big time thieves, terrorists, match fixing, MMS scandals, ransoms, crimes etc. Anything of too much becomes a nuisance, mobile phones are helpful or do much harm in terms of studies, concentration, focus, behavior and dependency? is the purpose of this survey and analysis in MBBS medical students.
Effects of Colored Plastic Film on Several Field Grown and Greenhouse Grown Cut Flower Species

The effects of colored plastic films were evaluated for growth and flowering of Ageratum houstonianum ‘Blue Horizon’, Antirrhinum majus ‘Maryland Appleblossom’, Celosia argentia var. cristata ‘Bombay Fire Apricot’, Viola ×wittrockiana ‘Majestic Giant Deep Blue with Blotch’, and Zinnia elegans ‘Oklahoma Pink’. Treatments consisted of light reflected from below into the plant canopy from black, blue, red, or white plastic film or a no film control. Treatment began when cotyledons unfolded on the seedlings. In the first experiment begun December, 2006, ageratum was tallest after 4 wks and 8 wks of growth on red and black film and shortest after being grown on blue film and the control. Fewest days to harvest were also found for ageratum on red and black film and the greatest on blue film. No differences in shoot height were found at 4 wks after treatment for celosia or snapdragon, but at 8 wks shoot height was tallest on red and black film and shortest in the control for celosia and blue film for snapdragon. Plant size was not affected in pansy, but shoot dry weight was largest on red film and smallest on black and blue film and the control. In the second experiment begun March, 2006, ageratum was again tallest after 7 wks of treatment on red and black film and shortest on blue film and the control. Unlike the first experiment, shoot heights of celosia were not
Changes in Total Energy, Nutrients and Food Group Intake among Children and Adolescents during the COVID-19 Pandemic—Results of the DONALD Study

The COVID-19 pandemic may have changed the habitual lifestyles of children and adolescents, in particular, due to the closure of kindergartens and schools. To investigate the impact of the pandemic on nutrients and food intake of children and adolescents in Germany, we analyzed repeated 3-day weighed dietary records from 108 participants (3–18 years; females: n = 45, males: n = 63) of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study. Polynomial mixed-effects regression models were used to identify prospective changes in dietary intake (total energy (TEI), carbohydrates, fat, protein, free sugar, ultra-processed foods, fruits and vegetables, sugar sweetened beverages and juices) before and during the first months of the COVID-19 pandemic. For the current analysis, we have chosen the first months of the pandemic (March 2020–August 2020), as this was the period with the most restrictions in Germany so far (kindergarten, school and restaurant closures; contact and outdoor activity restrictions). No significant changes in either the selected nutrients or food groups were observed. However, children and adolescents recorded a significantly lower TEI during the pandemic (β = −109.65, p = 0.0062). Results remained significant after the exclusion of participants with under-reported records (β = −95.77, p = 0.0063). While macronutrient intake did not change, descriptive data indicate a non-significant decrease in sugar sweetened beverages and ultra-processed foods intake. We suggest that children and adolescents from high socioeconomic families may have adapted lifestyle changes during the pandemic.
The Theory and Technology System of Green Manufacturing and Their New Frameworks

： The research related to Green Manufacturing (GM) has been over 20 years. To support the next stage of research and development, there is an urgent need to summarize the definition, theories, and technologies of GM. Based on the existing studies, the definition of GM has been updated firstly, followed by the theoretic framework to structure the GM’s Three-Degree Theory, Resource Mainline Theory, Product Life Cycle Theory, and Six Main Features. And then, the technological framework to structure GM’s 6R principle, three technological mainlines, five categories of specific techniques, and several management techniques across the product life cycle, has been established. Based on the theoretic and technological framework, the fundamental problem, goal, way, and routes have been structured and concluded in a theoretic-technological relation framework.
Based on Serum Raman and Fluorescence Spectra to Diagnose Liver Cancer

Background: Raman and fluorescence spectra techniques are potential tools for disease diagnosis. In recent years, the application of Raman and fluorescence spectra techniques in biological studies has increased a great deal, and clinical investigations relevant to cancer detection by spectroscopic means have attracted particularly attention from both clinical and non-clinical researchers. Methods: In this article, Raman and fluorescence spectra were employed for the detection of liver cancer and healthy individuals using their serum samples. These serum samples were compared with their spectral features acquired by Raman and fluorescence spectroscopy to initially establish spectral features that can be considered spectral markers of liver cancer diagnosis. Resuits: The intensity differences from characteristic peaks of carotene, protein and lipid associated Raman spectra were clearly observed in liver cancer patient serum samples versus normal human serum. The changes in the serum fluorescence profiles of liver cancer patients were also analyzed. To probe the capacity and contrast of Raman spectroscopy as an analytical implement for the early diagnosis of liver cancer, principal component analysis (PCA) was used to analyze the Raman spectra of controls , liver cancer patients and healthy individuals. Furthermore, the Partial Least Squares-Discriminant Analysis (PLS-DA) was performed to compare the diagnostic performance of Raman spectroscopy for the classification of disease samples and healthy samples.Conclusion: Compare with the existing diagnostic techniques, the Raman spectroscopy technique has an excellent advantage in extremely low sample requirements, ease of use and ideal screening procedures. Thus, Raman spectroscopy has great potential to be developed as a powerful tool for distinguishing between healthy and liver cancer serum samples.
Chloroplast phylogenomics in Camelina (Brassicaceae) reveals multiple origins of polyploid species and the maternal lineage of C. sativa

Abstract The genus Camelina (Brassicaceae) comprises 7–8 diploid, tetraploid, and hexaploid species. Of particular agricultural interest is the biofuel crop, C. sativa (gold-of-pleasure or false flax), an allohexaploid domesticated from the widespread weed, C. microcarpa. Recent cytogenetics and genomics work has uncovered the identity of the parental diploid species involved in ancient polyploidization events in Camelina. However, little is known about the maternal subgenome ancestry of contemporary polyploid species. To determine the diploid maternal contributors of polyploid Camelina lineages, we sequenced and assembled 84 Camelina chloroplast genomes for phylogenetic analysis. Divergence time estimation was used to infer the timing of polyploidization events. Chromosome counts were also determined for 82 individuals to assess ploidy and cytotypic variation. Chloroplast genomes showed minimal divergence across the genus, with no observed gene-loss or structural variation. Phylogenetic analyses revealed C. hispida as a maternal diploid parent to the allotetraploid Camelina rumelica, and C. neglecta as the closest extant diploid contributor to the allohexaploids C. microcarpa and C. sativa. The tetraploid C. rumelica appears to have evolved through multiple independent hybridization events. Divergence times for polyploid lineages closely related to C. sativa were all inferred to be very recent, at only ~65 thousand years ago. Chromosome counts confirm that there are two distinct cytotypes within C. microcarpa (2n = 38 and 2n = 40). Based on these findings and other recent research, we propose a model of Camelina subgenome relationships representing our current understanding of the hybridization and polyploidization history of this recently-diverged genus.
The Roles of S100A4 and the EGF/EGFR Signaling Axis in Pulmonary Hypertension with Right Ventricular Hypertrophy

Simple Summary Pulmonary hypertension (PH) is a condition characterized by increased pulmonary arterial pressure. PH can further lead to right ventricular hypertrophy (RVH) and, consequently, heart failure. Endothelial-to-mesenchymal transition (EndMT) was identified as a key process in PH pathology. Nonetheless, the exact systemic and local levels of EndMT factors have not been comprehensively studied so far. Here, we quantified S100A4, epidermal growth factor (EGF), and EGF receptor (EGFR) in serum and tissue samples of two classes of PH with RVH. Patients with left heart disease and healthy volunteers served as controls. Serum S100A4 was decreased in the PH groups investigated, while EGF levels were increased in one PH cohort. EGFR was diminished in all groups compared to healthy controls. Surgical treatment of PH showed no effect on systemic EndMT marker levels. Furthermore, we observed a positive correlation between advanced PH stages and S100A4. Together, these findings help to deepen our understanding of the complex molecular events contributing to PH pathology and disease progression. Abstract Pulmonary hypertension (PH) is characterized by increased pulmonary arterial pressure caused by the accumulation of mesenchymal-like cells in the pulmonary vasculature. PH can lead to right ventricular hypertrophy (RVH) and, ultimately, heart failure and death. In PH etiology, endothelial-to-mesenchymal transition (EndMT) has emerged as a critical process governing the conversion of endothelial cells into mesenchymal cells, and S100A4, EGF, and EGFR are implicated in EndMT. However, a potential role of S100A4, EGF, and EGFR in PH has to date not been elucidated. We therefore quantified S100A4, EGF, and EGFR in patients suffering from chronic thromboembolic pulmonary hypertension (CTEPH) and idiopathic pulmonary arterial hypertension (iPAH). To determine specificity for unilateral heart disease, the EndMT biomarker signature was further compared between PH patients presenting with RVH and patients suffering from aortic valve stenosis (AVS) with left ventricular hypertrophy. Reduced S100A4 concentrations were found in CTEPH and iPAH patients with RVH. Systemic EGF was increased in CTEPH but not in iPAH, while AVS patients displayed slightly diminished EGF levels. EGFR was downregulated in all patient groups when compared to healthy controls. Longitudinal data analysis revealed no effect of surgical therapies on EndMT markers. Pulmonary thrombo-endarterectomized samples were devoid of S100A4, while S100A4 tissue expression positively correlated with higher grades of Heath–Edwards histopathological lesions of iPAH-derived lung tissue. Histologically, EGFR was not detectable in CTEPH lungs or in iPAH lesions. Together, our data suggest an intricate role for S100A4 and EGF/EGFR in PH with right heart pathology.
The evolving landscape of sex-based differences in lung cancer: a distinct disease in women

In stark contrast to a few decades ago when lung cancer was predominantly a disease of men who smoke, incidence rates of lung cancer in women are now comparable to or higher than those in men and are rising alarmingly in many parts of the world. Women face a unique set of risk factors for lung cancer compared to men. These include exogenous exposures including radon, prior radiation, and fumes from indoor cooking materials such as coal, in addition to endogenous exposures such as oestrogen and distinct genetic polymorphisms. Current screening guidelines only address tobacco use and likely underrepresent lung cancer risk in women. Women were also not well represented in some of the landmark prospective studies that led to the development of current screening guidelines. Women diagnosed with lung cancer have a clear mortality benefit compared to men even when other clinical and demographic characteristics are accounted for. However, there may be sex-based differences in outcomes and side effects of systemic therapy, particularly with chemotherapy and immunotherapy. Ongoing research is needed to better investigate these differences to address the rapidly changing demographics of lung cancer worldwide. Sex-based differences in lung cancer span the care continuum. This suggests lung cancer may increasingly be viewed as a distinct disease in women, with implications for screening and treatment. Lung cancer research should capture these sex-based differences. https://bit.ly/2WfhaB4
Fiscal regimes and the exchange rate

In this paper, we argue that the effect of monetary and fiscal policies on the exchange rate depends on the fiscal regime. A contractionary monetary (expansionary fiscal) shock can lead to a depreciation, rather than an appreciation, of the domestic currency if debt is not backed by future fiscal surpluses. We look at daily movements of the Brazilian real around policy announcements and find strong support for the existence of two regimes with opposite signs. The unconventional response of the exchange rate occurs when fiscal fundamentals are deteriorating and markets’ concern about debt sustainability is rising. To rationalize these findings, we propose a model of sovereign default in which foreign investors are subject to higher haircuts and fiscal policy shifts between Ricardian and non-Ricardian regimes. In the latter, sovereign default risk drives the currency risk premium and affects how the exchange rate reacts to policy shocks. JEL classifications: E52, E62, E63, F31, F34, F41, G15
Resilience and associated factors in women survivors of Intimate Partner Violence: a systematic review

Most research on Intimate Partner Violence against women (IPV) has tended to present women as passive victims, but in recent years, there has been an increase in studies adopting a strengths-based approach. The aim of the present study is to review the empirical literature about resilience in women survivors of IPV to (a) analyze the consensus on the definition and assessment of resilience; (b) study the correlates of resilience; and (c) reflect on the applicability of such knowledge in policies and professional practice. Following PRISMA guidelines, a systematic search was carried out in the Scopus, WoS and PsycINFO databases. The search yielded 42 articles published in English or Spanish over an unlimited timeframe. Results showed that process-oriented, trait-oriented, and outcomes-oriented definitions of resilience were all adopted in the research and that assessment methods also differed across studies. Individual, relational, and contextual factors were found as resilience correlates.There is a need for a theoretical consensus and for research on the mechanisms through which vulnerability or protective factors exert their influence on groups with specific risk conditions. Finally, governments and institutions should take actions to support women and children and to prevent future IPV. Gran parte de los estudios sobre Violencia de Género en la Pareja (VGP) presentan a las mujeres como víctimas pasivas, pero en los últimos años el número de investigaciones centradas en fortalezas está aumentando. El objetivo del presente estudio es revisar la literatura empírica sobre resiliencia en mujeres supervivientes de VGP para: (a) analizar el consenso en la definición y evaluación de resiliencia; (b) estudiar los correlatos del constructo; y (c) reflexionar sobre la aplicabilidad de este conocimiento en las políticas y la práctica profesional. Siguiendo las guías PRISMA, se realizó una revisión sistemática en las bases de datos Scopus, WoS y PsycINFO, encontrando 42 artículos publicados en inglés o español sin restricción temporal. Los resultados muestran que los estudios adoptan definiciones de resiliencia tanto orientadas al proceso como al rasgo y a los resultados, y que el método de evaluación difiere entre investigaciones. Entre los correlatos de resiliencia se encontraron factores individuales, relacionales y contextuales. Se necesita un consenso teórico y profundizar en los mecanismos por los cuales los factores de vulnerabilidad o protección afectan a grupos con riesgos específicos. Por último, los gobiernos e instituciones deberían emprender acciones de prevención y de apoyo a las mujeres e hijos/as.
The Atacama Desert in Northern Chile as an Analog Model of Mars

The Atacama Desert is by far the driest and oldest desert on Earth, showing a unique combination of environmental extremes (extreme dryness, the highest UV radiation levels on Earth, and highly saline and oxidizing soils), explaining why the Atacama has been largely investigated as a Mars analog model for almost 20 years. Based on the source and the amount of water available for life and its analogy with Mars, two ecosystems are of interest in the Atacama: its Coastal Range and the much drier hyperarid core, which we here review in detail. Members of the three domains of life have been found across these ecosystems living at the limit of habitability, suggesting the potential dry limits for each domain and also unveiling the highly patchy distribution of microbial life in its most extreme regions. The thorough study of the Atacama has allowed us to understand how life has adapted to its extreme conditions, the specific habitats that life occupies in each case (thus suggesting the most likely places in which to search for evidence for life on Mars), and the number of biosignatures detected across this desert. Also, the characterization of west-to-east transects across this desert has shown to be of significant value to understand the potential adaptations that Martian microorganisms may have followed in an ever-drying planet. All of this explains why the Atacama is actively used as the testing ground of the technologies (detection instruments, rovers, etc.) that were sent and will be sent to Mars. We also highlight the need to better inform the exact locations of the sites studied to understand general trends, the need to identify the true native microbial species of the Atacama, and the impact of climate change on the most arid and most Martian desert of Earth.
Influenza A Virus Uses PSMA2 for Downregulation of the NRF2-Mediated Oxidative Stress Response

Influenza A virus (IAV) remains one of the most significant infectious agents, responsible for 3 million to 5 million illnesses each year and more than 50 million deaths during the 20th century. The cellular processes that promote and inhibit IAV infection and pathogenesis remain only partially understood. ABSTRACT Influenza A virus (IAV), an obligatory intracellular parasite, uses host cellular molecules to complete its replication cycle and suppress immune responses. Proteasome subunit alpha type 2 (PSMA2) is a cellular protein highly expressed in IAV-infected human lung epithelial A549 cells. PSMA2 is part of the 20S proteasome complex that degrades or recycles defective proteins and involves proteolytic modification of many cellular regulatory proteins. However, the role of PSMA2 in IAV replication is not well understood. In this study, PSMA2 knockdown (KD) in A549 cells caused a significant reduction in extracellular progeny IAV, but intracellular viral protein translation and viral RNA transcription were not affected. This indicates that PSMA2 is a critical host factor for IAV maturation. To better understand the interplay between PSMA2 KD and IAV infection at the proteomic level, we used the SomaScan 1.3K version, which measures 1,307 proteins to analyze alterations induced by these treatments. We found seven cellular signaling pathways, including phospholipase C signaling, Pak signaling, and nuclear factor erythroid 2p45-related factor 2 (NRF2)-mediated oxidative stress response signaling, that were inhibited by IAV infection but significantly activated by PSMA2 KD. Further analysis of NRF2-mediated oxidative stress response signaling indicated IAV inhibits accumulation of reactive oxygen species (ROS), but ROS levels significantly increased during IAV infection in PSMA2 KD cells. However, IAV infection caused significantly higher NFR2 nuclear translocation that was inhibited in PSMA2 KD cells. This indicates that PSMA2 is required for NRF2-mediated ROS neutralization and that IAV uses PSMA2 to escape viral clearance via the NRF2-mediated cellular oxidative response. IMPORTANCE Influenza A virus (IAV) remains one of the most significant infectious agents, responsible for 3 million to 5 million illnesses each year and more than 50 million deaths during the 20th century. The cellular processes that promote and inhibit IAV infection and pathogenesis remain only partially understood. PSMA2 is a critical component of the 20S proteasome and ubiquitin-proteasome system, which is important in the replication of numerous viruses. This study examined host protein responses to IAV infection alone, PSMA2 knockdown alone, and IAV infection in the presence of PSMA2 knockdown and determined that interfering with PSMA2 function affected IAV maturation. These results help us better understand the importance of PSMA2 in IAV replication and may pave the way for designing additional IAV antivirals targeting PSMA2 or the host proteasome for the treatment of seasonal flu.
Modeling Of Solid Waste Composting Under Uncertainty

Effectiveness in reflecting uncertainties in a modeling process is critical for ensuring forecasting accuracy and improving process efficiency. However, few previous studies made efforts toward incorporating uncertainties into comporting modeling systems. The purpose of this study is to develop a methodology based on Monte Carlo simulation and factorial design to reflect uncertainties in the modeling process. The uncertain parameters under consideration include temperature, moisture content, free air space, and oxygen concentration. Monte Carlo simulations are undertaken based on comporting kinetic simulator, and a set of 24 factorial experiments are conducted to examine the effects of the input uncertainties and their interactions. The results indicate that complexities of the system uncertainties have been effectively addressed through the developed modeling approach. The proposed method offers an effective tool for comporting process simulation and control under uncertainty.