Miracle-dz/UniFAR-FTUs huggingface dataset:
Coalition Governance in Central Eastern Europe

Coalitions among political parties govern most of Europe’s parliamentary democracies. Traditionally, the study of coalition politics has been focused on Western Europe. Coalition governance in Central Eastern Europe brings the study of the full coalition life-cycle to a region that has undergone tremendous political transformation, but which has not been studied from this perspective. The volume covers Bulgaria, Estonia, the Czech Republic, Latvia, Lithuania, Hungary, Poland, Romania, Slovakia, and Slovenia. It provides information and analyses of the cycle, from pre-electoral alliances to coalition formation and portfolio distribution, governing in coalitions, the stages that eventually lead to a government termination, and the electoral performance of coalition parties. In Central Eastern Europe, few single-party cabinets form and there have been only a few early elections. The evidence provided shows that coalition partners in the region write formal agreements (coalition agreements) to an extent that is similar to the patterns that we find in Western Europe, but also that they adhere less closely to these contracts. While the research on Western Europe tends to stress that coalition partners emphasize coalition compromise and mutual supervision, there is more evidence of ‘ministerial government’ by individual ministers and ministries. There are also a few coalition governance systems that are heavily dominated by the prime minister. No previous study has covered the full coalition life-cycle in all of the ten countries with as much detail. Systematic information is presented in 10 figures and in more than one hundred tables.
Acute interstitial nephritis associated with immune checkpoint inhibitors: a single-centre experience

Abstract Background Checkpoint inhibitors (CPIs) are used to treat solid organ metastatic malignancies. They act by triggering a vigorous immune response against tumoural cells, preventing their proliferation and metastasis. However, this is not a selective response and can cause immune-related adverse events (irAEs). The kidney can potentially be damaged, with an incidence of irAEs of 1–4%. The most frequent type of toxicity described is acute interstitial nephritis (AIN). Methods We conducted a study of patients with solid organ metastatic malignancies treated with immunotherapy who developed acute renal injury and underwent kidney biopsy in the last 14 months at the Vall d’Hebron University Hospital. Results In all, 826 solid organ malignancies were treated with immunotherapy in our centre, 125 of them (15.1%) developed acute kidney injury (AKI), 23 (18.4% of AKI) visited the nephrology department and 8 underwent kidney biopsy. The most frequent malignancy was lung cancer, in five patients (62%), followed by two patients (25%) with melanoma and one patient (12%) with pancreatic cancer. Four patients (50%) had already received previous oncological therapy, and for the remaining four patients (50%), CPI was the first-line therapy. Five patients (62%) were treated with anti-programmed cell death protein 1, three patients (37%) received anti-programmed death ligand 1 and two (25%) patients were treated in combination with anti-cytotoxic T-lymphocyte antigen 4. The time between the start of CPI and the onset of the AKI ranged from 2 to 11 months. The most frequent urine findings were subnephrotic-range proteinuria, with a mean protein:creatinine ratio of 544 mg/g (standard deviation 147) and eosinophiluria. All patients were biopsied after being diagnosed with AIN. Three patients (37%) received treatment with pulses of methylprednisolone 250–500 mg/day and five patients (62%) received prednisone 1 mg/kg/day. Seven patients (87%) experienced recovery of kidney function and one patient (12%) progressed to chronic kidney disease. Conclusions We report on eight patients with CPI-related AIN diagnosed in the last 14 months at our centre. The novel immunotherapy treatment of metastatic solid organ malignancies carries a higher risk of irAEs. The kidney is one of the most commonly affected organs, frequently presenting as an AIN and exhibiting a favourable response to steroid treatment.
Increasing Destructive Potential of Landfalling Tropical Cyclones over China

This study investigates the trend in destructive potential of landfalling tropical cyclones (TCs) in terms of power dissipation index (PDI) over mainland China in the period of 1980–2018. Results show that both the accumulated PDI and averaged PDI after landfall show significant increasing trends. The increasing trends are found to be contributed primarily by the increasing mean duration of TCs over land and the increasing TC intensity at landfall. Further analyses indicate that the increase in landfalling TC intensity prior to and at landfall, the decrease in intensity weakening rate after landfall, and the northward shift of landfalling TC track density all contribute to the longer duration of TCs after landfall. Moreover, the conducive large-scale conditions, such as the increases in coastal sea surface temperature and land surface temperature and soil moisture, the decrease in low-level vertical wind shear, and the increase in upper-level divergence, are all favorable for intense landfalling TCs and their survival after landfall, thus contributing to the increasing destructive potential of landfalling TCs over China.
Developing a Critical Discourse About Teaching and Learning: The Case of a Secondary Science Video Club

ABSTRACT Video is used widely to support teachers’ learning and enactment of responsive instruction. Informed by principles of video club design, we designed a video club to support secondary science teachers developing a vision of responsive teaching, attention to student thinking, and a critical discourse to analyze their own and others’ efforts to enact responsive practices. In this study, we investigate if and how teachers developed a critical discourse in this context. Analysis reveals that the group developed a more collaborative, interpretive, and evidence-based discourse about teaching and learning. These findings contribute to research on video clubs as a professional development model to support teacher learning, as well as make visible how teachers shifted to develop a more critical lens for discussing teaching and learning. This study has implications for designing professional learning that will result in sustained, generative development in the context of instructional reform.
Regional Wheat Yield Estimation by Integration of Remotely Sensed Soil Moisture into a Crop Model

Abstract A field study was conducted to estimate the regional wheat yield by integration of remotely sensed soil moisture index into CERES-Wheat model. The calibration and evaluation of model was performed using experimental data and then applied on the area of Faisalabad district for yield estimation. Area of Faisalabad district was divided into 7929 cells for independent simulations. The weather data of the wheat season were used uniformly to all cells, while site-specific soil data were used for each cell. Recommended crop management practices were used in the model for all cells. Median normalized difference water index (NDWI) were used to estimate the irrigation amount for each cell. The estimated yield was validated with observed yield of 25 random farms. Model calibration results showed a good agreement between observed and simulated values of grain yield (RMSE = 284.8 kg ha−1). The validation of model at regional scale showed a close association with simulated and observed yield of 25 farms (R2 = 0.71). The regional yield estimation results indicated that grain yield varies from 1500 to 3593 kg ha−1 in Faisalabad district. The estimated mean yield was 2979 kg ha−1, which was 5.2% higher than the yield reported by Crop Reporting Service (CRS), Punjab.
Cuminum cyminum methanolic extract – Fe3O4 nanocomposite: A novel and efficient insecticide against the potato tuber moth (Lepidoptera: Gelechiidae) to protect potatoes

Phthorimaea operculella is a significant insect pest of cultivated potatoes in tropical and subtropi- cal regions such as Iran. Since the potato is one of the most valuable sources of human food, non-chemical control of potato pests is essential. Application of medicinal plant extracts is a low-risk alternative method to synthetic chemical insecticides. Hence, the present study was conducted to investigate a potential strategy to improve the insecticidal activity of plant extracts for efficient management of P. operculella . The insecti- cidal efficacy of pure methanolic extract (PME) and Fe 3 O 4 @methanolic extract (FME) of Cuminum cyminum were evaluated against the potato tuber moth under laboratory conditions. The morphological characteristics of Fe 3 O 4 @Cumin were investigated by scanning electron microscope. Magnetic properties of the samples were determined using a vibration sample magnetometer. XRD was used to prove the crystalline structure of Fe 3 O 4 @Cumin. SEM, FTIR, XRD, and VSM analyses confirmed that the methanolic extract was loaded on Fe 3 O 4 . The toxicity of PME and Fe 3 O 4 @Cumin were evaluated on one-day-old eggs and penetration the first instar larvae of P. operculella into potato tubers and leaves. The LC 50 values of Cumin extract and Fe 3 O 4 @ Cumin were 961.07 and 601.48 and 496.84 and 268.82 ppm for penetrating neonate larvae to tubers and leaves, and 874.90 and 595.16 ppm for eggs, respectively. Bioassays revealed that Fe 3 O 4 @Cumin was more toxic than non-formulated Cumin methanolic extract against eggs and neonate larvae of P. operculella . The formulated methanolic extract was significantly more repellent against the pest. Our results suggested that the prepared nanocomposite could be used as a new effective tool for P. operculella management strategies to protect potatoes.
Diabetes and Collagen: Interrelations

This review summarizes information on interrelations between diabetes development and collagen metabolism and structure. The growing global problem of diabetes requires the search for new strategies of its complications correction. Among them collagen structure violations and/or its impaired metabolism most often lead to profound disability. Even after several decades of intense studies, pathophysiological mechanisms underlying collagen changes in diabetes mellitus are still not well clear. The main complication is that not only diabetes cause changes in collagen metabolism and structure. Collagens via some mechanisms also may regulate glucose homeostasis, both directly and indirectly. The author also presented the results of own studies on bone and skin type I collagen amino acid composition changes with diabetes. Deepening our understanding of collagen metabolism and diabetes interrelations allows us to optimize approaches to overcome the collagen-mediated consequences of this disease. Recently, it has been clearly demonstrated that use of only antidiabetic agents cannot fully correct such violations. Preparations on the base of flavonoids, collagens and amino acids could be considered as perspective directions in this area of drug development.
A Retrospective Analysis: Injured Youth Athletes' Imagery Use During Rehabilitation

The purpose of this study was to expand our breadth of knowledge and fill a gap in the literature regarding injured youth athletes’ imagery use during injury rehabilitation, using a retrospective qualitative approach. The participants were 12 young adults who had sustained an injury as an adolescent (during the previous five years) forcing them to miss time in their sport due to the injury. During the interviews, the participants described their use of imagery during sport injury rehabilitation including when, where, why and for what purpose they used imagery. They reported using imagery during sport rehabilitation for cognitive, motivational, pain management and healing purposes. Motivational imagery was used to set rehabilitative goals and develop confidence in returning to sport, while cognitive imagery was used to learn and rehearse sport and rehabilitation skills and strategies. Pain management imagery was used to distract from pain sensations, block the pain, and practice dealing with the pain, while healing imagery was used for internal physiological processes. With respect to what they imaged, participants commented on the timing, effectiveness, nature, modalities, and “other” details regarding their imagery use. Overall, implementing imagery in conjunction with physical rehabilitation may enhance the rehabilitative process for young injured athletes, thereby increasing the rates of physiological recovery.
Variation in Sensory Attributes and Volatile Compounds in Beers Brewed from Genetically Distinct Malts: An Integrated Sensory and Non-Targeted Metabolomics Approach

Abstract Previous research demonstrates that barley genetics can influence beer flavor. However, the chemical basis for differences in beer flavor attributed to barley is not well defined. Here, the associations between beer volatile compounds and sensory descriptors were investigated in a controlled experiment, whereby barley genotype was the main driver of variation in the system. Beer was brewed from three advanced barley breeding lines and compared to a CDC Copeland control. Sensory studies were performed via three independent panels (a consumer, brewery, and laboratory panel). The results suggest that the four beer samples have distinct flavor profiles that could be discriminated by the three sensory panels. Volatile compounds for the four beers were characterized using HS/SPME-GC-MS; quantitation and annotation were performed using a non-targeted metabolomics approach on 397 detected compounds. The O2PLS data analysis supports that alkane/alkenes, benzenoids, amides/amines, and fatty acid esters were associated with the most desirable lager traits, compared to Maillard Reaction Products that were more abundant in the beers with “non-ideal” lager traits. Taken together, these data further support the role of barley genetics in beer flavor and provide new information on the types of volatile metabolites that can vary in controlled systems.
Smartphone Addictions: A Review of Themes, Theories and Future Research Directions

This research work presents a literature review on "Smartphone Addiction" (SA). The papers used for this review were retrieved from AIS (All Repositories), Elsevier, Wiley Online, Tailor and Francis and JSTOR databases using the phrase "Smartphone Addiction". In all, 13 AIS top conferences and 31 peer-reviewed journals searched from 2007 to July 2018 returned 1572 papers. This paper details the findings based on the literature assessment of 128 publications. In terms of context and geographical gaps, Asia leads the chart with 39 articles representing 30.5percent and Africa recorded only 1 paper used for this work. Online data collection with global focus had 37 articles representing 28.9percent and quantitative methodology was adopted by 91 articles representing 71.1percent. SA research was more at the micro and meso levels. This review has demonstrated that literature offers several perspectives on SA but failed to establish a causal theory or a model that fully accounted for urge and craving phenomena from an IS design principle perspective to mitigate SA. Also, smartphones are devices (artifacts) that enable users to access and become addicted to applications such as video games, SNSs, emails, etc. Future research should, therefore, focus more on addictive activities and applications on these devices.
Rapid identification and susceptibility pattern of various Candida isolates from different clinical specimens in a tertiary care hospital in Western Uttar Pradesh

Background: Candida species are component of normal flora of human beings. Candidiasis is the commonest fungal disease affecting mucosa, skin, nails and internal organs. A variety of predisposing factors are known to cause candidiasis either by altering balance of normal microbial flora of the body or by lowering the host defence. Methods: A total of 90 specimens submitted in the department of microbiology were included in this study. Identification of Candida species as well as antifungal sensitivity testing was performed with Vitek®2 compact (Biomerieux France) using Vitek2 cards for identification of yeast and yeast like organisms (ID-YST cards). Antifungal susceptibility testing was performed using Vitek2 fungal susceptibility card (AST YS01) kits respectively. Results: The distribution of the clinical samples were urine 53 (58.9%), sputum 14 (15.5%), blood 10 (11.1%), nail 6 (6.7%) and high vaginal swab 7 (7.8%). Among 90 clinical isolates, species obtained were C. tropicalis 53 (59%), C. albicans 23 (25.5%), C. glabrata 6 (6.7%), C. parapsilosis 4 (4.4%), C. krusei 2 (2.2%), C. pelliculosa 1 (1.1%), C. famata 1 (1.1%). Conclusions: Infections caused by non-candida albicans species have increased. Identification of Candida species and their antifungal susceptibility are important for the treatment of hospitalized patients with serious underlying disease.
A study on the role of receptor (ER,PR,HER-2/neu) in patients of carcinoma breast

Objective: To evaluate the expression of HER-2/neu, estrogen receptor (ER) and progesterone receptor (PR) in breast carcinomas. Methods: This was a prospective hospital based study conducted on patients of carcinoma breast. The study population comprised of patients who were diagnosed to have carcinoma breast on the basis of preliminary Trucut biopsy/ open biopsies, and subsequently underwent surgery for the disease. All patients who had undergone previous chemo or radiotherapy were excluded from the study. A total of 72 patients were included in the study. Results: About one third of patients were between 41-50 years of age (30.6%). TNM stage IIIB was among in 30.6% patients and IIIA was in 25%. Tumor grade III was among more than half of patients (61.1%). Infiltrating ductal carcinoma was among 88.9% patients. ER and PR was positive in 41.7% and 25% patients respectively. ER-/PR- was among 54.2% patients. HER2neu was positive in 22.2% of the patients. Luminal A and B was in 36.1% and 13.9% patients respectively. Conclusion: Breast cancer in Indian patients has been found to be histologically aggressive, presents at a younger age, and is less likely to be susceptible to conventional hormonal and targeted antibody treatment. Detecting and treating this increasingly important cause of mortality is an enormous challenge.
Performance Parameters, Plasma Lipid Status, and Lymphoid Tissue Fatty Acid Profile of Broiler Chicks Fed Camelina Cake

27/May/2019 Approved: 24/September/2019 ABSTRACT The effects of dietary camelina cake (CAMC) on broiler chicks’growth performance, plasma lipid status and fatty acid profile (FA) of lymphoid organs were evaluated. Six hundred broilers (3-week-old, Cobb 500) were randomly allotted for 20 days in a feeding trials into 2 groups: control (C; corn-soybean meal-canola meal basal diet) and experimental (CAMC; 80 g CAMC/kg diet replaces canola meal from C diet). Blood samples (n=12/group) were collected on day 42 for plasma profile analysis (glucose, Glu; total cholesterol, TC; high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; triglycerides) and immune organs (spleen, thymus, bursa of Fabricius) for FA analysis. The FA profile of lymphoid tissue was determined by gas chromatography. Feeding the CAMC diet did not influence broilers performance parameters or relative weights of lymphoid tissue, except the weight of bursa that decreased ( p <0.05). Plasma lipids profile was affected by decreasing ( p <0.05) the concentrations of Glu, TC, HDL-C and LDL-C in broilers fed the CAMC diet. In all lymphoid tissue, the total content of n-3 polyunsaturated fatty acids (PUFA) increased (p<0.001) and the total level of n-6 PUFA decreased ( p <0.001) as the effect of the CAMC diet. The n-6:n-3 ratio decreased ( p <0.001) up to 5:1 in all lymphoid tissue. The higher ( p <0.05) concentration of arachidonic acid was found in the spleen, followed by the thymus and the bursa of the chicks fed the CAMC diet. Our results indicate that feeding 80 g/ kg camelina cakes in broiler chicks finisher diet had no negative impact on productivity, beneficially alter the plasma lipid status and fatty acids profile
Multi-Level Sources of Work-Life Balance: Evidence from the Public Health Sector in Tanzania

Purpose - This study aims at examining different sources of work-life balance support using survey data obtained from the public health sector employees in Tanzania. We further explore gender differences in employees’ work-life balance satisfaction, investigating how male and female workers perceive different levels of work-life balance support depending on whether work-life balance support comes from government, organization, direct supervisor, or family. <br><br>Design/methodology/approach - A quantitative study was carried out among 253 full-time male(N= 108) and female(N=145) employees in the Tanzanian public hospital employees. The hierarchical multiple regression analyses were conducted to analyze the data. <br><br>Findings - We find strong support for our hypotheses. Employee satisfaction with work-life balance is significantly related to each and every support he or she obtains from different, multi-level entities, that is, government, organization, direct supervisor, or family. Moreover, our findings suggest that female and male slightly differ in their perceived level of work-life balance support and this difference appears varied contingent on sources of work-life balance support. <br><br>Research implications or Originality - This study responds to explicit calls for understanding divergent sources of work-life balance satisfaction and gender differences in such phenomenon. The current study using the context of public health sectors in Tanzania is expected to contribute to shedding better light on the contextual factors shaping gender differences in employees’ work-life balance satisfaction, with theoretical as well as practical implications for organizations and policy makers in their endeavors toward designing more effective work-life balance measures.
Modelling the Replay of Dynamic Memories from Cortical Alpha Oscillations with the Sync-Fire / deSync Model

We here propose a neural network model to explore how neural oscillations might regulate the replay of memory traces. We simulate the encoding and retrieval of a series of events, where temporal sequences are uniquely identifiable by analysing population activity, as several recent EEG/MEG studies have shown. Our model comprises three parts, each considering distinct hypotheses. A cortical region actively represents sequences through the disruption of an intrinsically generated alpha rhythm, where a desynchronisation marks information-rich operations as the literature predicts. A binding region converts each event into a discrete index, enabling repetitions through a sparse encoding of events. We also instantiate a temporal region, where an oscillatory “ticking-clock” made up of hierarchical synfire chains discretely indexes a moment in time. By encoding the absolute timing between events, we show how one can use cortical desynchronisations to dynamically detect unique temporal signatures as they are replayed in the brain.