Miracle-dz/UniFAR-FTUs huggingface dataset:
OTT_A_219063 10885..10895

*These authors contributed equally to this work Background: Cancer stem cells (CSCs) have been proposed as central drivers of cancer relapse in many cancers. In the present study, we investigated the inhibitory effect of 20(R)Ginsenoside Rg3 (Rg3R), a major active component of ginseng saponin, on CSC-like cells and the Epithelial-Mesenchymal Transition (EMT) in colorectal cancer (CRC). Methods: The effects of ginsenoside Rg3R on the colony-forming, migration, invasion, and wound-healing abilities of CRC cells were determined in HT29 and SW620 cell lines in vitro. Further, ginsenoside Rg3R was given intraperitoneally at 5mg/kg of mouse body weight to check its effect on the metastasis of CRC cells in vivo. Results: Ginsenoside Rg3R significantly inhibited CSC properties, but did not affect cell proliferation. Moreover, ginsenoside Rg3R treatment significantly inhibited the motility of CRC cells based on migration, invasion, and wound-healing assays. The inhibitory effects of ginsenoside Rg3R on CRC are potentially mediated by significant down-regulation of the expression of stemness genes and EMT markers in CRC cells in a SNAIL-dependent manner. Furthermore, ginsenoside Rg3R treatment decreased both the number and size of tumor nodules in the liver, lung, and kidney tissues in a metastasis mouse model. Conclusion: These findings highlighted the potential use of ginsenoside Rg3R in clinical applications for colorectal cancer treatment.
Study on the productive and reproductive performance of 3 native genotypes of chicken under intensive management

To improve the native chicken, a total of 75 males and 750 females was reared from the 3 types of chicken namely, Naked neck (NN), Hilly and Non descript deshi (ND) which have been collected from different parts of the country. The number of each Naked neck (NN), Hilly and Non descript deshi (ND) type of chicken in the foundation stock genotypes were 275 (250 females and 25 males). Multiplication of the established birds has already been started and the present stock will be increased as required for future selective breeding work. These foundation stocks were raised under confinement with standard management practices and vaccination. They were supplied the nutrient as per recommendation. All productive, reproductive and egg quality parameters at 38 weeks of age were studied. The results indicate that the percentage of hatchability on fertile eggs and set eggs and also dead in shell (embryonic mortality) were significantly different (P<0.01) among genotypes. No significant difference (P>0.05) was observed in age at sexual maturity, fertility, dead in germ, normal chicks and abnormal chicks among the 3 native genotypes. Significantly difference (P<0.01) was found in body weight among the 3 native genotypes at 38 weeks of age. Egg weight was similar in NN (42.94) and ND (42.08) and lowest in Hilly (40.25). No significant difference (P>0.05) was found in morning egg production rate, egg production, feed intake and survivability. But significantly (P<0.01) highest afternoon egg production was found in NN (32.68%) and lowest and similar in Hilly (27.23%) and ND (28.31%). The egg quality traits; egg weight, yolk index and shell thickness were significantly different (P<0.05), but the other egg quality traits were not significantly different (P>0.05) among 3 genotypes. The native germplasm is very much potential in context of disease resistant and genetic variability under the existing harsh environment. So we can use these for future breeding program to improvement and upgrading the native genotypes and exotic one.
Effect of Guantong Formula on the Restenosis after Intracoronary Bare Stenting

Objective To evaluate the effect of Guantong Formula(Formula for the stenosis of coronary artery)on the restenosis after intracoronary bare stenting.Methods Totally 120 patients after successful intracoronary bare stenting were randomized into control group and treatment group.The control group was treated with routine medicines,based on which the treatment group was administered Guantong Formula.The treatment course was 6 months.Quantitative coronary analysis was made for all patients with the angiograms of pre-intervention,post-intervention and follow-up for comparing the incidence of restenosis and diameter of involved blood vessel of both groups.Results The coronary angiographic examination showed that the restenosis rate of the control group was 23.73% while that of the treatment group was 9.84%,the difference was significant(P0.05). After treatment,in the late stage,the loss of diameter in the treatment group was smaller than that of the control group(P0.05),the minimum diameter,the net gain of luminal diameter,and the net gain of luminal area were all larger than those of the control group(P0.05 or P0.01). Conclusion Guantong Formula is effective in preventing restenosis after intracoronary bare stenting.
The Proper Time Geometry

Historically, quantum mechanics was developed on the same geometry of space-time that Einstein described in his 1904 paper on Special Relativity (SR), the LorentzMinkowski Geometry (LMG). Since then, the unification of gravitation and quantum mechanics has resisted all efforts. Perhaps the problem is with the use of the LMG. While this familiar geometry is conceptually the simplest that supports SR, it is not unique in that achievement. This paper describes an alternative geometry that does the same through the use of a hidden dimension. The theory of Quantum mechanics gives a few clues that the LMG is not the correct one for describing a local geometry of space-time. The most obvious clue is that of causality. “Quantum field theory solves the causality problem in a miraculous way, . We will find that, in the multiparticle field theory, the propagation of a particle across a spacelike interval is indistinguishable from the propagation of an antiparticle in the opposite direction. When we ask whether an observation made at point x0 can affect an observation made at point x, we will find that the amplitudes for particle and antiparticle propagation exactly cancel – so causality is preserved. ” [1, page 14] Thus causality is preserved for the results of the computations of the theory, but they are not present in the mechanism itself. The problem of causality arises due to the lack, in SR of a preferred reference frame. We will assume that there is a preferred reference frame, and therefore that the propagation of particles across spacelike intervals is not a causality problem. Of course we will also assume that the structure of space-time makes it impossible, or exceedingly difficult, to locate that preferred reference frame. From a calculational point of view, this small detail is no change from the current theory. It is a philosophical choice only, but a choice that will allow us to explore geometries other than the LMG. Nor is this choice of interpretation new, it dates to the dawn of relativity and is known as Lorentzian Relativity (LR). Lorentzian Relativity has been generalized to match General Rela-
The association between intellectual capital and financial performance in the Islamic banking industry

Purpose - The purpose of this study is to empirically investigate the impact of intellectual capital (IC) on the financial performance of Islamic banks operating in the Gulf Cooperation Council (GCC) countries. Design/methodology/approach - The study measures IC by the value added intellectual coefficient model. A regression analysis was used to assess the impact of IC on financial performance. The research sample consisted of Islamic banks operating in the GCC countries during the years 2011, 2012 and 2013. Data originated from the annual reports of Islamic banks. Findings - The results support the thesis that IC has a positive impact on the financial performance of Islamic banks. Even though the average IC is lower than that reported in other studies, the positive effect on financial performance is obvious. The findings also show that human capital (HC) is higher than capital employed (CE) and structural capital (SC). The study reveals that SC has an insignificant impact on the financial performance of the Islamic banks compared to CE and HC. Practical implications - The findings provide empirical evidence that IC affects the Islamic banks’ financial performance. It helps Islamic banks in the GCC countries to understand how to use their IC efficiently, especially SC as it is yet to be used efficiently. Also, the findings benefit the relevant authorities (e.g. legislators and central banks) who could use them to emphasise strategic policy reforms whenever required. Originality/value - The current research adds to the empirical studies in the GCC countries as it views the region as a collective as opposed to individual countries. It also extends the IC and performance measurement literature of Islamic banks in the GCC countries. Moreover, the current study enriches the limited literature on IC in the context of Islamic banking.
Self-Control and Exercise: A Review of the Bi-Directional Relationship

Self-control has been defined as the mental capacity of an individual to alter, modify, change or override their impulses, desires, and habitual responses. In this review, we will discuss the bi-directional nature of the relationship between self-control and exercise. In brief, higher levels of trait self-control have been associated with greater exercise performance and adherence; whilst the depletion of state self-control has been shown to decrease performance and persistence on subsequent exercise tasks requiring self-control. In the opposite direction, long-term participation in exercise (and improved physical fitness) has been demonstrated to enhance self-control. Furthermore, an acute bout of exercise has been shown to enhance subsequent self-control, particularly when the exercise is of a moderate intensity and requires some degree of cognitive engagement. Throughout, when discussing each of these relationships, evidence will be drawn from other aspects of the review, where appropriate, to enhance our understanding of the observed effects. Finally, recommendations for future research will be made; including the importance of considering the bi-directional nature of the relationship, given that this has implications for our understanding of both self-control and exercise performance and adherence.
INFLUENCE OF PERFORMANCE APPRAISALS ON EMPLOYEE PRODUCTIVITY AMONG COUNTY GOVERNMENTS IN KENYA

It has been argued that performance appraisal is an important component in measuring and improving organizational performance and consequently employee productivity. However, it has also been argued that when the appraisal is done devoid of proper appraisal criteria, feedback and a reward system; staff morale, motivation and productivity may be significantly negatively affected. However, the extent to which the performance appraisal as exercised by the County Governments influence the aspect of employee productivity had not been studied exhaustively and thus, this study elaborated the situation. This study thus sought to determine the influence of performance appraisal on employee productivity at the County Governments. Significance: This study is of significant to the County Governments management with information about the state and aspects of proper and effective performance appraisal and how performance appraisal will help improve employee productivity. Theories: Expectancy theory, theory of planned behaviour and the Hertzberg’s two-factor theory anchored the study and utilized a descriptive research design to target the 1199 staff from five County Governments, which included:Homabay, Bomet, Kericho, Nyamira and Kisii Counties. Findings: The results show that: performance appraisal criteria (β=.373, t=3.943, p<0.001); performance appraisal feedback (β=.153, t=1.086, p<0.004); performance appraisal rewarding (β=.304, t=1.747, p<0.001); performance appraisal training (β=.332, t=3.947, p<0.001) had significant positive influence on employee productivity in County Governments. The study therefore recommends that: The County Governments’ management through their human resource departments should devise new performance appraisals that factor in best practice and best fit criteria that are canvassed and agreed upon by majority of employees.
Gotta catch’em all: ready, set, (pokemon) GO!

Pokemon Go is a virtual reality game that mixes the smart mobile technology with real life exploration. The aim of this research is to investigate whether Pokemon Go app increases the levels of physical activity. Thirty-two healthy subjects were included in this 5-week study (12 males and 20 females, age 18-49) and they were allocated into three groups, experimental group: new trainers (N=10) and control groups: regular trainers (N=11) and nontrainers (N=11). Level of physical activity was assessed using Pedometer – Step Counter Free & Calorie Burner that counts daily walking distance in km and steps. Subjects were instructed to provide screenshots of their km recorded. At each level of measurement groups significantly differed in walking distance (p<0.01). The time did not have significant effect on the walking distance. The interaction effect was significant from fourth level to fifth level of measurement (p<005). LSD test revealed that regular trainers significantly differed from both, new and non-trainers, having the most walked distance. New trainers and non-trainers did not differ in the level physical activity in the first three weeks, but in the fourthand fifth-week new trainers group significantly increased the levels of physical activity regarding non-trainers group (mean difference +21.688 and +15.688, respectively). In the first two weeks, the new trainers group walked 27km, and after the installation of the games, the increase was more than 10 km. It could be concluded that Pokemon Go app has impact on the levels of physical activity, but some period of time is needed for participants to learn how to play the game and enjoy it.
DDDT_A_211907 4225..4238

Despoina Pantazi 1 Nikoleta Ntemou Alexios Brentas Dimitrios Alivertis Konstantinos Skobridis Alexandros D Tselepis 1Department of Chemistry, Atherothrombosis Research Centre, Laboratory of Biochemistry, University of Ioannina, Ioannina 45110, Greece; 2Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina 45110, Greece; 3Department of Biological Applications and Technology, University of Ioannina, Ioannina 45110, Greece Background: Platelets play important roles in cancer progression and metastasis, as well as in cancer-associated thrombosis (CAT). Tyrosine kinases are implicated in several intracellular signaling pathways involved in tumor biology, thus tyrosine kinase inhibitors (TKIs) represent an important class of anticancer drugs, based on the concept of targeted therapy. Purpose: The objective of this study is the design and synthesis of analogues of the TKIs imatinib and nilotinib in order to develop tyrosine kinase inhibitors, by investigating their molecular requirements, which would express antiplatelet properties. Methods: Based on a recently described by us improved approach in the preparation of imatinib and/or nilotinib analogues, we designed and synthesized in five-step reaction sequences, 8 analogues of imatinib (I–IV), nilotinib (V, VI) and imatinib/nilotinib (VII, VIII). Their inhibitory effects on platelet aggregation and P-selectin membrane expression induced by arachidonic acid (AA), adenosine diphosphate (ADP) and thrombin receptor activating peptide-6 (TRAP-6), in vitro, were studied. Molecular docking studies and calculations were also performed. Results: The novel analogues V–VIII were well established with the aid of spectroscopic methods. Imatinib and nilotinib inhibited AA-induced platelet aggregation, exhibiting IC50 values of 13.30 μΜ and 3.91 μΜ, respectively. Analogues I and II exhibited an improved inhibitory activity compared with imatinib. Among the nilotinib analogues, V exhibited a 9-fold higher activity than nilotinib. All compounds were less efficient in inhibiting platelet aggregation towards ADP and TRAP-6. Similar results were obtained for the membrane expression of P-selectin. Molecular docking studies showed that the improved antiplatelet activity of nilotinib analogue V is primarily attributed to the number and the strength of hydrogen bonds. Conclusion: Our results show that there is considerable potential to develop synthetic analogues of imatinib and nilotinib, as TKIs with antiplatelet properties and therefore being suitable to target cancer progression and metastasis, as well as CAT by inhibiting platelet activation.
INNOVATION ROLE OF ENTREPRENEURS IN POVERTY REDUCTION AMONG MICRO AND SMALL ENTERPRISES IN PLATEAU STATE, NIGERIA

Micro and small enterprises played key role in most economies of the world. They served as engine room of growth in developed countries of the world. Innovation role of entrepreneurs in poverty reduction among micro and small enterprises have led to increased income among owners of enterprises in both developed and developing nations. Most developed nations of the world achieved growth and development due to successful roles played by micro and small enterprise sector. Nigeria one of the most populous countries in Africa, has over half of its population living on less than one dollar per day. This study aimed at determining innovation role of entrepreneurs in poverty reduction among micro and small enterprises in Plateau State, Nigeria. Descriptive and inferential research designed anchored the study. The study target population comprised of all registered micro and small enterprises (MSEs) in Plateau State, Nigeria. The sample size comprised of 342 respondents. A standard questionnaire with both closed and open ended questions was administered to the MSEs owners. The findings of this study revealed that innovation role of entrepreneurs in MSEs played significant role in poverty reduction in Nigeria. The study concluded that adopting modern innovation in product development and business operation improves performance and reduces poverty among MSE owners. The study recommended among others that micro and small enterprises should be innovative and always seek for creative destruction and come out with new products or services.
Does Job Satisfaction Mediate the Effect of Organizational Change and Organizational Culture on Employee Performance of the Public Works and Spatial Planning Agency?

This study explores the mediated effect of job satisfaction on the influences of organizational change and organizational culture on staff performance of the Public Works and Spatial Planning Agency, Pidie District, Aceh province, Indonesia. All 209 staff of the agency were selected as the sample of study using census technique. To gather the data, the study distributed structured questionnaires to the respondents. Adopting the structural equation modeling (SEM) approach, the study found that job satisfaction significantly mediated the influences of organizational change and organizational culture on staff performance. These findings implied that any effort to enhance staff performance, it should be focused on the improvement of job satisfaction.
THE INFLUENCE OF MARKETING AND FINANCIAL MANAGEMENT TRAINING ON PERFORMANCE OF MICRO SMALL AND MEDIUM ENTERPRISES IN NAIROBI COUNTY, KENYA

The Micro and Small Enterprises Authority of Kenya was established under the Micro and Small Enterprise Act Number 55 of 2012, to manage and provide support to the Micro Small and Medium Enterprises in the country. Whereas it has run various capacity building workshops targeted at the players in this sector, it has not carried out any study to find out the extent to which the various training programs they have carried out have impacted the target groups’ businesses. This paper seeks to answer the question as to what effect the Training conducted by the MSEA has had on the performance of Micro, Small and Medium Enterprises in Nairobi County of Kenya. Target population of 8744 and a sample of 370 registered entrepreneurs who are members of the six targeted Jua Kali Associations spread out in Nairobi County. Findings showed financial management training and marketing training had moderate influence on performance of MSMEs with regression coefficients of 0.304 and 0.260 respectively. The study concludes that Micro and Small Enterprise Authority needs to make more effort to enhance the contribution of their training programs on performance since they were found to have low and moderate effect even though positively and with statistical significance. The study recommends the introduction of other support programmes aside from training since training only accounted for moderate percent of the influence in performance of MSMEs.
Debarya glyptosperma (De Bary) Wittrock 1872 (Zygnemataceae, Chlorophyta) as a possible airborne alga – a contribution to its palaeoeocological interpretation

This paper reports the fi nding of Debarya glyptosperma zygospores in xeric grasslands far from the natural habitat of algal species. This fact suggests that this species is an airborne alga and this has not been reported before. What is more the discoidal shape of the zygospores may dispose this taxon among the Zygnemataceae family towards air dispersion. This new information may assist in assessing it as an indicator of limnic conditions. However, the simple discovery of Debarya without any accompanying algal taxa and/or other water plants should not be conclusively interpreted as proof of the existence of water bodies because the zygospores might originate from distant transport.
CMAR_A_201943 5163..5169

1Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan; 2Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan; 3Public Health Bureau, Tainan City Government, Tainan, Taiwan; 4Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan; 5School of Medicine, Chung Shan Medical University, Taichung, Taiwan; 6Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; 7Department of Emergency Medicine, Changhua Christian Hospital, Changhua, Taiwan; 8Graduate Institute of BioMedical Sciences, China Medical University, Taichung, Taiwan; 9Environment-Omics-Diseases Research Center, China Medical University Hospital, Taichung, Taiwan; 10Toxicology and Biomedicine Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
OWNERSHIP MOTIVATION AS A DETERMINANT OF STRATEGIC PLANNING IN SMALL AND MEDIUM ENTERPRISES IN KENYA

Strategic planning is concerned with the setting of long-term organizational goals, the development and implementation of plans to achieve these goals and the allocation or diversion of resources necessary for realizing these goals. Comprehensive reviews of extant studies into SMEs suggest that, ceteris paribus, a key determinant of business success lies in the absence or presence of strategic planning. Hence, the purpose of this study was to establish motivational determinants of strategic planning in SMEs in Kenya. The findings are that majority of the enterprises had no business plans. Of those with plans, most were informal, long-term and were reviewed half yearly or yearly. Furthermore, majority of the enterprises had no vision and mission statements. However, most of the owner-managers had formulated strategic objectives and strategies for their enterprises. The study further established that motivation for business ownership had a partial influence on strategic planning in SMEs in Kenya. Specifically, personal development and push motivations had an influence on strategic planning in SMEs in Kenya while financial and flexible lifestyle motivations did not have an influence.