Miracle-dz/UniFAR-FTUs huggingface dataset:
Spectrum of Histopathological, Immunohistochemical, Molecular and Radiological Features in 12 Cases of BCOR::CCNB3-positive Sarcomas With Literature Review

Introduction BCOR::CCNB3-positive undifferentiated sarcomas are rare. Herein, we present clinicopathological features including immunohistochemical and molecular data, along with the radiological profile of 12 such tumors. Methods Tumors were tested for BCOR::CCNB3 fusion by reverse transcription polymerase chain reaction (RT-PCR) technique. Eight tumors were tested for EWSR1 and three for SS18 gene rearrangements by fluorescence in situ hybridization, and two for SS18::SSX fusion by fragment analysis. Results Ten of 12 patients were male with ages ranging between 4 and 17 years (median = 13, average = 14.4). Nine tumors occurred in bones and three in soft tissues (median size = 8 cm). Four of five tumors within the appendicular bones were metadiaphyseal and appeared as permeative lesions, invariably associated with cortical thickening. Three tumors displayed mineralization. Histopathologically, the tumors comprised round to epithelioid cells with round to oval to spindle-shaped nuclei, mostly diffusely arranged in a myxoid stroma with intervening thin-walled vessels. Immunohistochemically, tumor cells were positive for BCOR (10/11), SATB2 (8/9), TLE1 (5/6), cyclinD1 (4/4), and EMA (3/8). All tumors revealed BCOR::CCNB3 fusion transcript. Nine patients underwent neoadjuvant chemotherapy, including five who underwent surgical resection, with two patients, who received adjuvant radiation therapy. A single patient, each, underwent palliative chemotherapy and palliative radiotherapy, respectively. Four patients developed pulmonary metastasis and three developed local recurrences. Four patients were alive-with-disease and two were free-of-disease. Conclusions It is crucial to identify BCOR::CCNB3 fusion-positive sarcomas, given significant treatment-associated implications. Certain clinicoradiological, histopathological features, absent EWSR1 rearrangement and BCOR, SATB2, and TLE1 immunoexpression are useful for triaging these tumors for molecular testing. A review of the literature on these ultra-rare tumors, including their diagnostic mimics is presented.
Characterization of Cu(In, Ga)Se 2 thin films and devices sputtered from a single target without additional selenization

Typically, Cu(In, Ga)Se 2 (CIGS) thin films for photovoltaic devices are deposited by co-evaporation or, alternately, by deposition of the metals with, or followed by, treatment in a selenium environment. In this proceeding, we describe CIGS films that are instead deposited by RF magnetron sputtering from a single quaternary target without any additional selenization. Devices built with these films exhibit efficiencies as high as 9.9%. These results represent the first report of working CIGS devices fabricated by sputtering without additional selenization. We demonstrate that deposition power can be varied in order to change the film morphology and improve device performance.
Convection Currents in a Porous Medium

The problem is considered of the convection of a fluid through a permeable medium as the result of a vertical temperature‐gradient, the medium being in the shape of a flat layer bounded above and below by perfectly conducting media. It appears that the minimum temperature‐gradient for which convection can occur is approximately 4π2h2μ/kgρ0α D2, where h2 is the thermal diffusivity, g is the acceleration of gravity, μ is the viscosity, k is the permeability, α is the coefficient of cubical expansion, ρ0 is the density at zero temperature, and D is the thickness of the layer; this exceeds the limiting gradient found by Rayleigh for a simple fluid by a factor of 16D2/27π2kρ0. A numerical computation of this gradient, based upon the data now available, indicates that convection currents should not occur in such a geological formation as the Woodbine sand of East Texas (west of the Mexia Fault zone); in view of the fact, however, that the distribution of NaCl in this formation seems to require the existence of .
Impact‐Noise Characteristics of Female Hard‐Heeled Foot Traffic

It has been said that the ISO tapping machine does not yield data on representative flooring materials that accurately relate to the impact‐noise isolation provided for real, foot‐fall impacts. To understand this problem, we have measured the impact force under both the ISO hammer and a woman's shoe heel. The hammer force is found to be much more intense and generally to contain more high‐frequency components than the heel force. The differences between hammer and heel forces are found to arise from the different mechanical internal admittances and from the different approach velocities. Radiated sound levels for the measured force spectra applied to a concrete slab are calculated and found to agree closely with measured impact sound levels. We conclude that the ISO machine grossly misrepresents the impact isolation provided by some typical floor surfaces.
Comparison of several generating partitions of the Hénon map

The existence and uniqueness of generating partitions in non-hyperbolic dynamical systems is usually studied in a simple, exemplary system, namely the Henon map at standard parameter values a = 1.4 and b = 0.3. We compare its standard partition with three other binary partitions, which are quite different from the standard partition but also appear to be generating. One of these partitions passes twice through the same orbit of homoclinic tangencies, providing a counterexample to a recent conjecture by Jaeger and Kantz ( J. Phys. A: Math. Gen. 30 L567). Introducing some simple rules to manipulate symbolic sequences, we show how to translate symbolic sequences produced by one partition into sequences produced by the other partitions. This proves that all these partitions are as good approximations to generating partitions as the standard partition. We also construct an infinite number of binary partitions, which are all quite similar to the standard partition, derive their translation rules, and prove the same equivalence. It is not known for sure whether any of these partitions is indeed generating. But if one of them is generating, then they all are.
Four-Year-Olds Share General Knowledge and Use Generic Language When Teaching

Abstract Young children’s receptiveness to teaching is unquestioned, but their understanding of pedagogy has only begun to be explored. Two experiments (N = 90; 45 female) with 4-year-olds from racially and ethnically diverse backgrounds were conducted to test if they exchange general information and use generic language when teaching. Children in both experiments taught more general than episodic information and used more generic than episodic language when teaching. Experiment 2 showed that children did not prefer to report general information or use generic language in a non-pedagogical context. The findings suggest that by 4 years old, children understand that the goal of teaching is to transmit general knowledge.
Augmentative and alternative communication for Aboriginal Australians: Developing core vocabulary for Yolŋu speakers

Abstract Yolŋu, Aboriginal people from Arnhem Land, Australia are at risk of Machado-Joseph disease, with progressive loss of speech. Yolŋu are interested in developing augmentative and alternative communication (AAC) systems in their own languages. This research aimed to develop a culturally responsive process to explore and create a core vocabulary word list for Yolŋu adults living with the disease for inclusion in AAC system prototypes. A list of 243 Yolŋu words and morphemes was created. In this highly collaborative, mixed methods, participatory action research, Balanda (the Yolŋu word for non-Aboriginal people) and Yolŋu researchers conducted cycles of transcription and analysis of a language sample, with oral group discussions to identify which words to include, omit, or add, based on Yolŋu perceptions of the structure and use of their languages. A Yolŋu metaphor, Gulaka-buma (“Harvesting yams”), was identified by Yolŋu researchers to represent and share the research process and findings. Three key themes were identified that summarize the main cultural and linguistic considerations related to changes made to the core vocabulary. Study findings emphasized the role of language as an expression of culture and identity for Indigenous peoples and the importance of considering cultural and linguistic factors in selecting vocabulary for AAC systems.
Validation of Two MHD Models of the Solar Corona with Rotational Tomography

We demonstrate a validation of two 3D MHD models of the corona by comparing density values from solar rotational tomography (SRT) to densities and morphological properties of the two MHD solutions for CR 2029 (2005 April 21-May 18). The two MHD models are given by the Stanford and Michigan models, and both use the same synoptic magnetogram from MDI as a lower boundary condition. The SRT reconstructions are based on polarized white-light images MLSO Mk IV data for the region between 1.1 and 1.5 R☉ (solar radii) and LASCO C2 for the region between 2.3 and 6.0 R☉. While the Stanford MHD model reasonably reproduces the tomographic density over the south pole, it fares less well over the north pole, and the Michigan MHD model underestimates the density over both poles. At lower latitudes, we find that while the MHD models have better agreement with the tomographic densities in the region below 3.5 R☉, at larger heights the agreement is more problematic. Our interpretation is that the base densities and temperatures of the models need to be improved, as well as their radial density gradients.
Does the CDC COVID-19 Exposure Assessment Criteria for Healthcare Personnel Work in a Healthcare Setting in Pakistan?

OBJECTIVE To evaluate the real-world performance of the CDC's "Interim US guidance for risk assessment and work restriction for healthcare personnel with exposure to COVID-19" at a private healthcare system in Pakistan. STUDY DESIGN Retrospective observational study. PLACE AND DURATION OF STUDY The Aga khan University Hospital, Karachi, and its associated healthcare facilities in all four provinces of Pakistan, from February to September 2020. METHODOLOGY Healthcare personnel (HCPs) assessed and tested for exposures to COVID-19 were included in the study. An exposure category was assigned to each HCP presenting with exposure to COVID-19 based on the CDC criteria. Percentage positivity was recorded and compared among the different exposure categories. Logistic regression analysis was used to identify variables significantly associated with COVID-19 infection. RESULTS Three thousand Six hundred and forty-seven HCPs were assessed for exposure to COVID-19 of whom 603 (16.5%) tested positive. Percent positivity was highest in high-risk symptomatic HCPs (18.2%), 15.6% in low-risk symptomatic HCPs, and 11% in high-risk asymptomatic HCPs. After controlling for age, gender, area of work, and source of exposure, compared to low-risk asymptomatic HCPs, the odds of a positive SARS-CoV-2 PCR were 2.13 (95%CI: 1.49-3.04) for high-risk symptomatic, 1.66 (95% CI: 1.12-2.46) for low-risk symptomatic, and 1.18 (95% CI: 0.83-1.68) for high-risk asymptomatic HCPs. CONCLUSION Regardless of exposure category, HCPs with symptoms consistent with COVID-19 have the highest likelihood of testing positive. The CDC exposure risk assessment criteria work best for symptomatic HCPs. Testing asymptomatic HCPs with high-risk exposures may not be necessary in low-resource settings with a limited healthcare workforce. KEY WORDS COVID-19, Employee health, Occupational health and safety programs, Medical surveillance/screening, Return to work.
Modulation of attentional bias by hypnotic suggestion: experimental evidence from an emotional Stroop task

ABSTRACT Hypnosis is considered a unique tool capable of modulating cognitive processes. The extent to which hypnotic suggestions intervenes is still under debate. This study was designed to provide a new insight into this issue, by focusing on an unintentional emotional process: attentional bias. In Experiment 1, highly suggestible participants performed three sessions of an emotional Stroop task where hypnotic suggestions aiming to increase and decrease emotional reactivity towards emotional stimuli were administered within an intra-individual design. Compared to a baseline condition (without hypnotic suggestion), a significant increase in attentional bias was found when a hypnotic suggestion to increase emotional reactivity was administered. In contrast, the bias was eliminated when a suggestion to decrease emotional reactivity was administered. Experiment 2 investigated the effect of session repetition on attentional bias across three successive experimental sessions without hypnosis, and showed that the emotional Stroop effect did not vary across sessions. Hence, session repetition could not account for part of the modulation of attentional bias in Experiment 1. Taken together, the results suggest that specific hypnotic suggestions can influence elicitation of unintentional emotional processing. The implications are discussed regarding the locus of intervention of hypnotic suggestion in cognitive and emotional processes.
Hydrogels based on gelatin, xanthan gum, and cellulose obtained by reactive extrusion and thermopressing processes

Abstract Polysaccharides and proteins are compatible macromolecules that can be used to obtain biopolymeric hydrogels through physical interactions. In this study, an environmentally friendly strategy is being proposed to produce gelatin-xanthan gum- cellulose hydrogels, without the addition of chemical synthetic crosslinkers. Xanthan gum was employed as an alternative crosslinking agent, and cellulose was used as a potential reinforcing agent in the polymeric matrix. Firstly, the biopolymers were mixed by the extrusion process, and glycerol was used as a plasticizer. Then, the polymeric mixture was molded by thermopressing to obtain hydrogels as laminated films. All hydrogels formulations resulted in films with smooth surfaces, without pores or cracks, resulting in amorphous polymeric matrices. The obtained hydrogels had a pH-dependent degree of swelling, the highest swelling values were obtained at pH 4 (5.3–7.9 g/g) after 24 h of immersion. Cellulose acted as a reinforcing agent for hydrogels, increasing thermal stability, tensile strength, and Young’s modulus of films when employed at the higher level (7%). The strategy employed in this study to obtain nontoxic hydrogels without synthetic crosslinkers was effective, resulting in materials with promising properties to be used as pharmaceutical forms to deliver active compounds in cosmetic or pharmaceutical products.
Posterior probability-based optimization of texture window size for image classification

Texture provides spatial features complementary to spectral information in land cover classification of high spatial resolution imagery. In texture classification, window size is an important factor influencing classification accuracy, but selecting the optimal window size is difficult. In this paper, we propose an optimized window size texture classification method which can solve the window size selection problem. In order to validate the new method, we designed four classification experiments with different input features based on SPOT-5 imagery: (1) spectral features, (2) spectral features and single window size texture features, (3) spectral features and multiple window size texture features and (4) spectral features and optimized window size texture features based on posterior probabilities. Overall, the highest accuracy was obtained using the optimized window size texture classification, which does not require window size selection before classification. Furthermore, the results imply that optimized window size varies with land cover type.
INERTIAL PARTICLES IN A RANDOM FIELD

The motion of an inertial particle in a Gaussian random field is studied. This is a model for the phenomenon of preferential concentration, whereby inertial particles in a turbulent flow can correlate significantly. Mathematically the motion is described by Newton's second law for a particle on a 2-D torus, with force proportional to the difference between a background fluid velocity and the particle velocity itself. The fluid velocity is defined through a linear stochastic PDE of Ornstein–Uhlenbeck type. The properties of the model are studied in terms of the covariance of the noise which drives the stochastic PDE. Sufficient conditions are found for almost sure existence and uniqueness of particle paths, and for a random dynamical system with a global random attractor. The random attractor is illustrated by means of a numerical experiment, and the relevance of the random attractor for the understanding of particle distributions is highlighted.
Temperature and size‐dependence of the vaporization threshold of phase‐shift emulsions

Acoustic cavitation has proven to be important for several therapeutic applications of ultrasound. However, acoustic cavitation is difficult to initiate and sustain in the absence of cavitation nuclei, particularly in tissue. Phase shift emulsions are ideal candidates for cavitation nuclei for in vivo applications. These emulsions, which consist of superheated liquid perfluorocarbon droplets enclosed by albumin shells, may be vaporized with acoustic pulses, a process known as acoustic droplet vaporization (ADV). In this study, we determined the ADV threshold at 2 MHz as a function of temperature and droplet size. Studies were conducted with micro‐ and nano‐sized emulsions in a closed‐flow system immersed in a temperature controlled water bath. The emulsions were injected into a flow system and exposed to high intensity focused ultrasound (HIFU; acoustic parameters: 2 MHz, 10 cycles, 100 Hz pulse repetition frequency). A portable diagnostic ultrasound scanner was used to monitor for vaporization. Upon vapo.
Neuropsychological Disorders in Moderate Hyperphenylalaninemia: Literature Review

ABSTRACT Moderate hyperphenylalaninemia (mHPA) is a hydroxylase deficiency corresponding to phenylalanine levels, at newborn screening, below 360 μmol/l. The neurological impact of mHPA is usually considered to be very low, but few studies have investigated the neuropsychological profile of mHPA patients.A systematic review of the neuropsychological aspects of mHPA was therefore conducted.The results showed a preservation of cognitive functions (intelligence, memory, visuoperception…). However, several indicators point to executive difficulties in this population. In regard to the important impact of executive functions in daily life, it is essential to conduct other studies in mHPA patients by proposing an integrative approach.
Recombinant human thrombopoietin (rhTPO) of different dosing regimens for refractory/relapsed primary immune thrombocytopenia: a multicenter, randomized controlled trial and pharmacokinetics study

Abstract Recombinant human TPO (rhTPO) is effective for refractory/relapsed primary immune thrombocytopenia (ITP), but optimal dosing regimen remains elusive. In this multicenter, randomized, controlled trial, a total of 282 adult ITP patients (mean age 47.3 years; 82 men) with a platelet count ≤30 × 109/L or >30 × 109/L with active bleeding randomly received a once daily (QD) subcutaneous injection of 7500 U (n = 64) or 15000 U rhTPO for 14 injections, or 15000 U or 30000 U rhTPO once every other day (QOD) for 7 injections. The primary outcomes included change from baseline in platelet count and total response rate (TRR) on day 14. On day 14, the median increase of platelet count from baseline was the highest in the 15000-U QD group (167.5 × 109/L, interquartile range [IQR] 23.0–295.0 × 109/L), followed by the 30000-U QOD group (57.5 × 109/L, IQR 9.0–190.0 × 109/L) (ANCOVA P < .001; P = .266 with baseline count as a covariate). The TRR on day 14 was also the highest in the 15000-U QD group (63.2%), followed by the 30000-U QOD group (59.7%). The rate of grade 3 and above adverse events did not differ among the four groups. There were no new safety concerns. All 4 regimens are safe and well-tolerated. The 30000-U QOD regimen is practically indistinguishable in efficacy to the 15000-U QD regimen. Plain Language Summary What is the context? Relative thrombopoietin deficiency is implicated in primary immune thrombocytopenia (ITP), which is characterized by increased platelet destruction and impaired megakaryopoiesis. Patients who are innately unresponsive to or have relapsed after glucocorticoid treatment have limited treatment options. Recombinant human thrombopoietin (rhTPO) improves treatment response of primary ITP patients when added to high-dose dexamethasone. What is new? This trial sought to identify an optimal dosing regimen of rhTPO for patients who had failed or relapsed after glucocorticoid therapy. Of the 4 regimens, once daily 15000 U rhTPO for 14 injections yielded the greatest median increase in platelet count (167.5 × 109/L) from baseline and attained the highest total response rate on day 14 (63.2%). 30000 U rhTPO once every other day for 7 injections was effective in rapidly increasing platelet counts in the first 7 days. All 4 regimens were safe and well-tolerated. What is the impact? The 30000 U rhTPO once every other day regimen may offer an effective and safe regimen with less frequent injections, but future trials with longer follow-up are needed.
The role of pain-related disability on treatment outcome and psychosocial symptoms in patients with temporomandibular disorders – a pilot study

Abstract Objective The aim of the pilot study was to investigate the association of pain-related disability with the outcome of conservative treatment of temporomandibular disorders (TMD) and with depressive and non-specific physical symptoms among TMD pain patients utilizing Graded Chronic Pain Scale 1.0 (GCPS1.0) as a screening instrument. Material and methods The study included 80 adult patients who were referred to the Oral and Maxillofacial Department, Oulu University Hospital, Finland, due to TMD pain. At baseline, pain-related disability was assessed by using the GCPS1.0 according to the Research Diagnostic Criteria for TMD (RDC/TMD), and the patients were categorized into three TMD subtypes, 1–3. Patients were given conservative TMD treatment. At follow-up visits (1, 3, 6, and 12 months), patients evaluated the pain intensity on an NRS and described the treatment outcome and the severity of the TMD symptoms on a numerical scale. Results and conclusions Patients with TMD subtype 3 (moderate/severe disability) had the highest NRS scores and described their symptoms as most severe at each time point, statistically significantly so at 1-month and 6-month follow-up (p < .05). The highest proportion of depressive symptoms was found in TMD subtype 3 (p < .05). The current pilot study showed that moderate/severe TMD-related disability, based on the GCPS 1.0 as a screening tool, may be linked with poor treatment outcome and depressive symptoms. Studies with larger samples are needed to confirm the results.