Miracle-dz/UniFAR-FTUs huggingface dataset:
Universal Design for Learning across Formal School Structures in Europe—A Systematic Review

Over the past two decades, there has been a global movement towards creating more inclusive education systems and learning environments, which involves adopting transformative pedagogies, such as Universal Design for Learning (UDL). However, empirical research on UDL conducted across Europe has primarily focused on the higher education context, resulting in limited knowledge or publications on formal school settings. Therefore, the purpose of this article is to highlight empirical studies conducted across Europe that specifically focus on UDL in the formal school years. The study employed a systematic literature review, conducting an extensive search across three databases (Libsearch, Ebsco and Scopus). Empirical studies were selected based on predefined inclusion and exclusion criteria, and the results were analyzed using descriptive narrative synthesis. The results revealed that the included articles mainly explored students’ and/or teachers’ perceptions of various phenomena related to the learning process, predominantly employing a qualitative approach. The findings suggest a need for further research in this area, with a particular emphasis on explicit learning outcomes. Moreover, there appears to be a lack of research on UDL implementation in preschool and early years education.
A Study of Flooded and Rain Infiltration Relations With Surface Ponding

A Study of Flooded and Rain Infiltration Relations with Surface Ponding by Yehia Z. El-Shafei, Doctor of Philosophy Utah State University, 1970 Major Professor: Joel E. Fletcher Department: Agricultural and Irrigation Engineering The non-linear partial differential equation (combination of Darcy's law and continuity equation) has been used in this investigation to predict the flooded infiltration through soils possessing appreciable amount 'of clay and initially drier than its field capacity. One of the most important assumptions made in solving the differential equation is that the capillary conductivity-moisture content relationship is unique for each initial moisture content computation due to the different reaction of clay minerals with different initial moisture contents. Mathematical equations were also derived to predict: 1. The rate of the wetting front advance, prior to the occurrence of surface ponding, taking into account the effect of initial soil moisture content and rate of water application. 2. The time at which surface ponding takes place under different rain (sprinkler) intensities by utilizing the intake rate curve obtained under flooded infiltration.
Micronutrient deficiency with skin and systemic symptoms: a case report of acrodermatitis enteropathica

Zinc is an essential micronutrient involved in the metabolism of enzymes, proteins, carbohydrates and vitamins [1]. It also plays an important role in the defence mechanisms against pathogens [2, 3]. A decreased level of zinc causes a rare disease – acrodermatitis entero-pathica (AE). There are two forms of this disorder: primary
Success Factors for Female Entrepreneurs in Small and Medium Micro Enterprises (SMEs) - Fish Crackers Business

This study aims to determine the success factors of female entrepreneurs in Small and Medium Enterprises (SMEs) of fish crackers in Moro District, Karimun Regency—data collection techniques using a questionnaire. The data analysis method used in this research is descriptive analysis and confirmatory factor analysis (CFA). The results of this study indicate that of the 28 indicators analyzed, eight factors can be formed, namely personality factors, family support, Technology, Education, Quality of Nature, Confidence, Government Support, and Gender Discrimination. At the same time, the most dominant factor in the success of women entrepreneurs in Moro District, Karimun Regency, is the Personality factor, with a variance value of 28.029%. This research has implications that emphasize encouraging and supporting women's participation in the SME sector. Identifying success factors for women entrepreneurs can help design targeted training and capacity-building programs. Raising awareness among local communities about the economic and social contributions of SMEs led by women can lead to greater support and appreciation for business.
Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review

Persistent Organic Pollutants (POPs) such as dichlorodimethyltrichloroethane (DDT) are present and ubiquitous in the environment due to their resilient nature. DDT is a prevalent endocrine disruptor still found in detectable amounts in organisms and the environment even after its use was banned in the 1970s. Medline and Google Scholar were systematically searched to detect all relevant animal and human studies published in the last 20 years (January 2003 to February 2023) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In total, 38 studies were included for qualitative synthesis. This systematic search and review indicated that exposure to DDT is associated with female reproductive health issues, such as reduced fecundability; increased risk of preterm/premature deliveries; increased periods of gestation; alterations in the synthesis of crucial reproductive hormones (Progesterone and Oxytocin) through ion imbalances and changes in prostaglandin synthesis, myometrial and stromal hypertrophy, and edema; and variations in uterine contractions through increased uterine wet weight. There was also limited evidence indicating DDT as a carcinogen sufficient to instigate reproductive cancers. However, this review only takes into account the in vitro studies that have established a possible pathway to understand how DDT impacts female infertility and leads to reproductive cancers. Links between the pathways described in various studies have been developed in this review to produce a summarized picture of how one event might lead to another. Additionally, epidemiological studies that specifically targeted the exposure to DDT of females belonging to various ethnicities have been reviewed to develop an overall picture of prevailing female reproductive health concerns in different nations.
Natural killer cells and BNT162b2 mRNA vaccine reactogenicity and durability

Introduction Natural killer (NK) cells can both amplify and regulate immune responses to vaccination. Studies in humans and animals have observed NK cell activation within days after mRNA vaccination. In this study, we sought to determine if baseline NK cell frequencies, phenotype, or function correlate with antibody responses or inflammatory side effects induced by the Pfizer-BioNTech COVID-19 vaccine (BNT162b2). Methods We analyzed serum and peripheral blood mononuclear cells (PBMCs) from 188 participants in the Prospective Assessment of SARS-CoV-2 Seroconversion study, an observational study evaluating immune responses in healthcare workers. Baseline serum samples and PBMCs were collected from all participants prior to any SARS-CoV-2 infection or vaccination. Spike-specific IgG antibodies were quantified at one and six months post-vaccination by microsphere-based multiplex immunoassay. NK cell frequencies and phenotypes were assessed on pre-vaccination PBMCs from all participants by multi-color flow cytometry, and on a subset of participants at time points after the 1st and 2nd doses of BNT162b2. Inflammatory side effects were assessed by structured symptom questionnaires, and baseline NK cell functionality was quantified by an in vitro killing assay on participants that reported high or low post-vaccination symptom scores. Results Key observations include: 1) circulating NK cells exhibit evidence of activation in the week following vaccination, 2) individuals with high symptom scores after 1st vaccination had higher pre-vaccination NK cytotoxicity indices, 3) high pre-vaccination NK cell numbers were associated with lower spike-specific IgG levels six months after two BNT162b2 doses, and 4) expression of the inhibitory marker NKG2A on immature NK cells was associated with higher antibody responses 1 and 6 months post-vaccination. Discussion These results suggest that NK cell activation by BNT162b2 vaccination may contribute to vaccine-induced inflammatory symptoms and reduce durability of vaccine-induced antibody responses.
State-resolved studies of CO2 sticking to CO2 ice

Internal vibrations may affect the adsorption, scattering, and reactions of molecules impinging onto a surface. The energy of the ν 3 antisymmetric stretch vibration of CO2 slightly exceeds the desorption energy of CO2 bound to CO2 ice. We use supersonic molecular beam techniques and rovibrationally state-resolved excitation to determine whether this vibration affects condensation of gas phase CO2 to its ice. We detect sticking and CO2 ice formation using RAIRS and quantify the sticking probability using the King and Wells method with modulation of the vibrational excitation and Fourier transform based detection. We find that the influence of this vibration on the structure of the formed ice and on the sticking probability is negligible under our conditions. Based on our detection limit, we quantify the weighted average sticking probability at approximately 0.9 and the difference between the state-resolved and weighted average sticking probability as below 0.5%.
Inducing Mechanical Stimuli to Tissues Grown on a Magnetic Gel Allows Deconvoluting the Forces Leading to Traumatic Brain Injury

Traumatic brain injury (TBI), which is characterized by damage to the brain resulting from a sudden traumatic event, is a major cause of death and disability worldwide. It has short- and long-term effects, including neuroinflammation, cognitive deficits, and depression. TBI consists of multiple steps that may sometimes have opposing effects or mechanisms, making it challenging to investigate and translate new knowledge into effective therapies. In order to better understand and address the underlying mechanisms of TBI, we have developed an in vitro platform that allows dynamic simulation of TBI conditions by applying external magnetic forces to induce acceleration and deceleration injury, which is often observed in human TBI. Endothelial and neuron-like cells were successfully grown on magnetic gels and applied to the platform. Both cell types showed an instant response to the TBI model, but the endothelial cells were able to recover quickly—in contrast to the neuron-like cells. In conclusion, the presented in vitro model mimics the mechanical processes of acceleration/deceleration injury involved in TBI and will be a valuable resource for further research on brain injury.
Parental Engagement Using ‘4M’ Concept in the Education Development Process in Malaysia

The parental engagement across waves in the Malaysian Education Development Plan 2013-2025 is more focused in the context of 'academic achievement'. Therefore, parental engagement needs to be expanded and given a new concept. This action is important to enable them to interact more effectively and engage continuously in line with the current needs. This concept paper aims to propose a concept to empower of parental engagement in the educational development process in Malaysia. Epstein's model as a basis of reference via the practice of the four management processes (4M) namely; planning, organizing, leading, and controlling to empower parents' engagement more effectively. The methods used are through the analysis of the Malaysian Education Development Plan 2013-2025; in addition the literature review that related to parental engagement, Epstein’s Model and the Management Model. The result, a conceptual framework was developed as a proposed for parental engagement to practice the concept of 4M. The implications of the study contribute to the parents to engage continuously and support in order for the Ministry of Education Malaysia to implement the national education development process more effectively.
Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses

Background Pain management is critical to equine welfare with non-steroidal anti-inflammatory drugs (NSAID) commonly used in horses. However, systemic NSAID use is limited by harmful gastrointestinal and renal side effects. Intravenous regional limb perfusion (IVRLP) is a technique used in horses that produces high, local antibiotic concentrations while limiting systemic circulation. NSAID-IVRLP would be a novel method of local pain management while limiting systemic NSAID side effects. To date, NSAID-IVRLP administration has not been reported in horses. This study aimed to identify the pharmacokinetics and local complications associated with using the NSAID phenylbutazone (PBZ) for IVRLP in six standing adult horses. Methods PBZ-IVRLP, at a dose of 2.2 mg/kg PBZ, was performed in a randomly assigned forelimb cephalic vein in 6 standing, healthy adult horses. A placebo-IVRLP was performed in the contralateral forelimb for comparison. Systemic serum and radiocarpal joint synovial fluid PBZ concentrations were identified at various timepoints (before IVRLP T-0 h, just after tourniquet removal T-0.5, 1.5, 3, 5, 12, 16, and 24 h post IVRLP) for non-compartmental pharmacokinetic analysis and concentration over time curves. Local complications associated with PBZ-IVRP were evaluated for up to 7 days following PBZ-IVRLP using physical and ultrasonographic assessment. On day 7 horses were humanely euthanized with histology performed on both forelimbs at PBZ-IVRLP and placebo-IVRLP administration sites. Results Non-compartmental pharmacokinetics for PBZ, and its major metabolite oxyphenbutazone (OBZ), were determined for serum and synovial fluid. Synovial PBZ concentrations (mean ± SD; 1.9 ± 2.1 μg/mL) were significantly lower (p = 0.03; CI,0.46–7.36) than serum PBZ concentrations (5.8 ± 5.1 μg/mL) at any time point. Physical and ultrasonographic measurements were not significantly different between PBZ- and placebo-IVRLP forelimbs. The most common histologic findings included focal deep dermal/subcutaneous hemorrhage and edema. Two horses showed perivasculitis and one horse showed a resolving thrombus in the cephalic vein of the PBZ-IVRLP limb. This horse also had severe perivasculitis and fibrinosuppurative dermatitis/panniculitis in the placebo-IVRLP limb. Conclusion PBZ-IVRLP pharmacokinetics at a 2.2 mg/kg dose showed no benefit compared to systemic PBZ administration in standing adult horses. Local complications associated with PBZ-IVRLP were similar to placebo-IVRLP on physical and ultrasonographic evaluation.
Glucocorticoid Alleviates Mechanical Stress-Induced Airway Inflammation and Remodeling in COPD via Transient Receptor Potential Canonical 1 Channel

Background Increased airway resistance and hyperinflation in chronic obstructive pulmonary disease (COPD) are associated with increased mechanical stress that modulate many essential pathophysiological functions including airway remodeling and inflammation. Our present study aimed to investigate the role of transient receptor potential canonical 1 (TRPC1), a mechanosensitive cation channel in airway remodeling and inflammation in COPD and the effect of glucocorticoid on this process. Methods In patients, we investigated the effect of pathological high mechanical stress on the expression of airway remodeling-related cytokines transforming growth factor β1 (TGF-β1), matrix metalloproteinase-9 (MMP9) and the count of inflammatory cells in endotracheal aspirates (ETAs) by means of different levels of peak inspiratory pressure (PIP) under mechanical ventilation, and analyzed their correlation with TRPC1. Based on whether patients regularly used inhaled corticosteroid (ICS), COPD patients were further divided into ICS group (n = 12) and non-ICS group (n=15). The ICS effect on the expression of TRPC1 was detected by Western blot. In vitro, we imitated the mechanical stress using cyclic stretch and examined the levels of TGF-β1 and MMP-9. The role of TRPC1 was further explored by siRNA transfection and dexamethasone administration. Results Our results revealed that the TRPC1 level and the inflammatory cells counts were significantly higher in COPD group. After mechanical ventilation, the expression of TGF-β1 and MMP-9 in all COPD subgroups was significantly increased, while in the control group, only high PIP subgroup increased. Meanwhile, TRPC1 expression was positively correlated with the counts of inflammatory cells and the levels of TGF-β1 and MMP-9. In vitro, mechanical stretch significantly increased TGF-β1 and MMP-9 levels and such increase was greatly attenuated by TRPC1 siRNA transfection and dexamethasone administration. Conclusion Our results suggest that the increased TRPC1 may play a role in the airway inflammation and airway remodeling in COPD under high airway pressure. Glucocorticoid could in some degree alleviate airway remodeling via inhibition of TRPC1.
Long Noncoding RNA TALAM1 Is a Transcriptional Target of the RUNX2 Transcription Factor in Lung Adenocarcinoma

Abstract Background: Lung cancer is the leading cause of cancer death worldwide. It has been reported that genetic and epigenetic factors play a crucial role in the onset and evolution of lung cancer. Previous reports have shown that essential transcription factors in embryonic development contribute to this pathology. Runt-related transcription factor (RUNX) proteins belong to a family of master regulators of embryonic developmental programs. Specifically, RUNX2 is the master transcription factor (TF) of osteoblastic differentiation, and it can be involved in pathological conditions such as prostate, thyroid, and lung cancer by regulating apoptosis and mesenchymal–epithelial transition processes. In this paper, we identified TALAM1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) as a genetic target of the RUNX2 TF in lung cancer and then performed functional validation of the main findings. Methods: We performed ChIP-seq analysis of tumor samples from a patient diagnosed with lung adenocarcinoma to evaluate the target genes of the RUNX2 TF. In addition, we performed shRNA-mediated knockdown of RUNX2 in this lung adenocarcinoma cell line to confirm the regulatory role of RUNX2 in TALAM1 expression. Results: We observed RUNX2 overexpression in cell lines and primary cultured lung cancer cells. Interestingly, we found that lncRNA TALAM1 was a target of RUNX2 and that RUNX2 exerted a negative regulatory effect on TALAM1 transcription.
Sulfate and strontium isotopic variations of groundwater in the Lower Central Plain, Thailand

Sulfate and strontium isotope ratios were determined for river water and groundwater in order to examine the origins of dissolved ions/elements in confined aquifers under the Lower Central Plain of Thailand. Groundwater samples with sulfur isotope ratios of more than 20‰ increase in major ions concentrations with increasing sulfur isotope ratios. Considering the uppermost Bangkok clay to be formed at the time of transgression in the Holocene Warm Period, such groundwater is assumed to be formed by infiltration of paleo-seawater. This type of groundwater shows 87 Sr/ 86 Sr value around 0.7091, which is similar to the 87 Sr/ 86 Sr value of seawater after the Quaternary period. Although paleo-seawater has been suggested to be affected by sulfate reduction, in the present days redox condition has not been well understood. Details of groundwater environmental status and biogeochemical behaviour of the ions/elements including heavy metals must be investigated in future research with sufficient numbers of samples.
Contactless Patient Care Using Hospital IoT: CCTV-Camera-Based Physiological Monitoring in ICU

The continuous vital signs monitoring allows clinicians to timely assess the physiological conditions of the patient in intensive care unit (ICU). Internet of Things (IoT) in the hospital that integrated various sensors (e.g., cameras) may enable intelligent healthcare. In this article, we proposed a remote patient monitoring system that exploits closed-circuit television (CCTV) cameras in an IoT infrastructure as optical sensors for noncontact physiological measurement, extending its scope from surveillance to warding. The proposed monitoring system implemented the latest camera photoplethysmography algorithms for cardio-respiratory measurement, particularly focused on heart rate (HR) and breathing rate (BR) as fundamental biomarkers for earlier warning of deterioration. A clinical trial involving 25 critically ill patients was carried out in ICU, where the camera focal length (i.e., key impact factor) is thoroughly investigated. The clinical results show that our system achieves a mean absolute error (MAE) of 1.3 bpm for HR and 0.7 brpm for BR in the far-focus mode; an MAE of 1.0 bpm for HR and 1.8 brpm for BR in the near-focus mode, which are in the range of clinical acceptance. The comparison between the two modes suggests that the far-focus is more suitable for monitoring patient’s vital signs in this scenario. The success rate of HR and BR in the far-focus mode is 94.5% (MAE = 2 bpm) and 96.7% (MAE = 3 brpm), respectively. The prototypes show that the increased measurement coverage and convenience of CCTV cameras in an IoT system are useful for ubiquitous patient monitoring in hospital care units.
A Preliminary Study of New Experimental Low-Cost Fe–P-Based and Mn–Fe–P-Based Brazing Filler Metals for Brazing of Non-Alloy and Low-Alloy Steels

Seventeen new experimental filler metals from eight different alloy systems based on Fe–P–X and Mn–Fe–P–X (X = B, C, Si in various combinations) were created and experimented with. DSC analyses were performed to determine the solidus and liquidus temperatures and the melting ranges. Hardness measurements of the alloys were performed in the as-cast state. The alloys contain primary and eutectic intermetallic compounds that make them very hard with average hardness values ranging from 590 HV10 to 876 HV10. The wettability was determined at 1000 °C, 1040 °C and 1080 °C on C22 non-alloy steel and 15CrNiS6 low-alloy steel in Ar 4.6 and 78 vol% H2-22 vol% N2 atmospheres. The results show good wettability at T = 1080 °C in both atmospheres, as the contact angles were mostly ≤30°. Thirteen alloys exhibit very good wettability with average contact angles of ≤15.5°. Nine alloys exhibit excellent wettability with their average contact angles being ≤10°. Wettability improves at higher temperatures. The liquid alloys are reactive to solid steels and form a diffusion joint. Diffusion of P, B, C, and Si from the filler metal into the base material dealloys the composition of the melt near the joint interface. For the same reason, a continuous layer of solid solution forms on the joint interface. When brazing with filler metals rich in carbon, strong carburisation of steels can be observed near the joint.