Miracle-dz/UniFAR-FTUs huggingface dataset:
Sorafenib in the treatment of Chinese patients with advanced renal cell cancer

16127 Background: A prior phase III trial (TARGETs) demonstrated that sorafenib doubled median progression-free survival versus placebo in previously treated clear cell renal cell cancer (RCC) patients (pts). The trial was conducted to explore the efficacy and safety profile of sorafenib in Chinese patients with advanced RCC. Methods: A total of 62 patients were enrolled for the open-label, non- randomized trial from April 20 to Dec. 28, 2006 in 4 hospitals in China. Major inclusion criteria: Histologically confirmed unresectable and/or metastatic RCC, at least one measurable lesion, failed one prior systemic therapy in the last 4 months, ECOG PS 0, 1 or 2, life expectancy more than 12 weeks, good organ function, no brain metastasis. Objectives were to evaluate the safety and efficacy of Sorafenib 400 mg bid continuously, 4 weeks per cycle. Tumor response was evaluated every 2 cycles. Results: A total of 62 patients were included in safety assessment. These patients were 69% were male with median age was .
Post-userism

HCI is focused on improving the interactions we have with technology and innovating new types of interactions, as well as expanding the types of people for whom those interactions are designed. Central to these efforts is the simultaneously empowering and contested construct of the "user. " This paper examines what the construct of the user highlights, as well as what it conceals. We introduce post-userism, a perspective that simultaneously acknowledges the limits of, and proposes alternatives to, the central construct of the user as proxy for the "human" in HCI. Drawing on developments across the historical trajectory of HCI, we articulate how the user is enacted across four different levels of representation-systems, interface, design process, and the ideology and identify situations where the user breaks down. Synthesizing prior work, we offer a series of strategies for grappling with such situations. In doing so, we seek to overcome the limitations imposed by the user and develop a language that will aid in evolving the foundations of HCI by asking what, exactly, we place at the center of our scholarship and design.
Evaluate " Rifampicin Resistance " as Surrogate Marker for Rapid Detection of MDR - TB Using Real - Time PCR Directly on FNAC Samples of Tuberculous Lymphadenitis

Background : India has the dubious distinction of having second largest burden of MDR - TB cases in the world. According to WHO, MDR - TB is defined as resistance to isoniazid and rifampicin, the two most important drugs for treatment of TB. “Rifampicin resistance” is recommended as surrogate marker for MDR - TB by WHO, as at least, 90% of all rifampicin - resistant clinical isolates are also found resistant to isoniazid. Localization of genetic alterations in the 81 - b p “Rifampicin Resistance - Determining Region” of rpoB gene in 96% of rifampicin resistant strains make it particularly amenable for early detection of MDR - TB by molecular techniques like Real - Time PCR. Aim : Evaluation of “rifamipicin resistance” as surrogat e marker for rapid detection of MDR - TB using Real - Time PCR directly on FNAC samples of tuberculous lymphadenitis (TBLN). Materials and Methods : Eighty cases of TBLN undergoing anti - tubercular treatment (ATT) and 10 lymphadenitis cases of non - tuberculous origin (controls) were included in the study. To evaluate “rifamipicin resistance” as surrogate marker for rapid detection of MDR - TB, Real - Time PCR and conventional Drug Susceptible Testing (DST) were carried out.
Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. Revised ed.

Researchers affiliated with the International Nutrition Program at the University of Toronto reviewed 20 trials of vitamin A and morbidity and 10 trials of vitamin A and young child mortality to determine the effectiveness of vitamin A supplementation on reducing mortality and morbidity in children from developing countries. All the populations were characterized by general poverty high prevalence of stunting and clinical manifestations of vitamin A deficiency sufficiently prevalent to be considered a public health problem. The analysis using the random effect model confirmed that vitamin A supplementation does indeed reduce mortality rates in young children (by about 23%) (relative risk = 0.77 confidence interval = 0.68-0.88; p < 0.001). The 10 trials reported reductions in mortality associated with vitamin A supplementation ranging from 0 to 50%. Vitamin A supplementation reduced mortality rates regardless of gender and age between 6 months and 5 years. It had clear effects on mortality linked to diarrhea and measles. It apparently had no effect on mortality linked to respiratory infections and malaria. None of the mortality studies included children with biochemical evidence of vitamin A depletion with associated evidence of at least a low prevalence of xerophthalmia. The effect of vitamin A supplementation on morbidity is less clear than its effect on mortality. Vitamin A supplementation does not appear to improve general morbidity but does have a beneficial effect on severe morbidity. In the case of measles the evidence suggests that even after the onset of infection vitamin A supplementation can improve the course of the episode and the case fatality rate. In conclusion vitamin A probably has more of an effect on the processes linked to response to infection than to those linked to resistance to infection.
A Randomized Controlled Trial Comparing Intrathecal Morphine With Transversus Abdominis Plane Block for Postcesarean Delivery Analgesia

spread between insertion sites, with probably more reliable results achieved with triangle of Petit versus mid-axillary line placement.5 Second, intention to place local anesthetic in the TAP by no means guarantees correct placement even when guided by ultrasound. There is a learning curve which we have all experienced, and undoubtedly experienced operators can obtain high success rates with either a landmark only or ultrasound-guided approach. The only way to be sure an adequate regional block has been achieved is to confirm the dermatomal distribution of the block, and it is interesting that this has not been carried out in most of the randomized trials to date. Nevertheless the imprecision of needle placement during landmark-based TAP block is consistent with pediatric studies of ilioinguinal/iliohypogastric blocks, only 14% of which are correctly placed using a landmark-based technique.6 The abbreviation TAP does not stand for “trusty and perfect” as yet2 nor are outcome data currently available to support better results with ultrasound-guided approaches. However, few would argue with McDermott et al’s conclusion that their finding “y.makes a strong argument against any blind approach to TAP block and in favor of ultrasound guidance in all cases. ”
Aging and the Nervous System

Why should wait for some days to get or receive the aging and the nervous system book that you order? Why should you take it if you can get the faster one? You can find the same book that you order right here. This is it the book that you can receive directly after purchasing. This aging and the nervous system is well known book in the world, of course many people will try to own it. Why don't you become the first? Still confused with the way?
Pakistan Entomologist ACCELERATING INFESTATION OF PINK BOLLWORM PECTINOPHORA GOSSYPIELLA (SAUNDERS) (LEPIDOPTERA: GELECHIIDAE) ON BT–VARIETIES OF COTTON IN PAKISTAN

Pakistan is the fourth largest producer of cotton (Gossypium hirsutum L.) in the world after China, USA and India. It is the most important cash crop, cultivated on 2.879 million hectares in our country. It is not only source of large amount of foreign exchange contributing about 7.0% of value added in agriculture and about 1.5% of GDP but also contributes about 66.50% share in national oil production (Economic Survey of Pakistan, 2013). It is also a reasonable source of income for poor unskilled village labor and farming community, particularly women. The rural population constitutes more than two third of total national population (Zeeshan et al., 2010). Cotton is victim of a complex of insect pests including sucking pests and bollworms all over the world (Abdullah, 2010), but since the introduction and adoption of Bt cotton on larger scale in Pakistan, bollworm complex especially Helicoverpa armegera Hubner (Lepidoptera: Noctuidae) pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae) and spotted bollworms, Earias insulana Boisd as well as Earias vitella Fab. (Lepidoptera: Arctidae) are not a major problem in Bt cotton (Dhillon et al., 2011). The pink bollworm, P. gossypiella (Saunders) is considered to be one of the most injurious cotton pests because it is difficult to control with insecticides (Lykouressis et al., 2005). The pink bollworm larvae feed on flower buds, flowers, bolls, developing seeds within bolls, damage seeds ABSTRACT ARTICLE INFORMATION
Mapping smart mobility

The society is changing with increased urbanization and populations, and a lack of sustainability in the construction of today’s society, which leads to more efficient and connected mobility being essential for the survival of the society. This thesis evaluates the preferences that the society has on smart mobility, and the society in this thesis represent the university, industry, local government and the citizens. Moreover, it will evaluate which trends that will affect the development of smart mobility, and lastly the problems in the way to working with smart mobility. The study is qualitative, consisting of a literature review and 18 interviews within the triple helix. The triple helix consists of three actor categories; local government, industry and university, which is used to get a broad understanding of the situation by combining the views of the different actors, compare and explain current research systems in a social context. The concluding preferences that were found on smart mobility are; efficient mobility system, robustness, affordability, sustainability, and simplicity for the end user. The efficient mobility system is divided into three parts: area efficient transport, infrastructural investment, and optimization of logistics. However, infrastructural investment and optimization of logistics were found to be more of necessary solutions than preferences. The identified trends for smart mobility are; electrification, autonomous technologies, digitalization, and servitization. These trends will likely permeate the future development of smart mobility, especially servitization as the society is changing to be more service focused than product focused. We also found that the current way of working is not aligned across the triple helix with a need for coordination and collaboration as well as lack of a vision for the mobility system. The lack of coordination and collaboration increases the difficulty in creating relevant solutions for the mobility system. The coordination and collaboration can be solved by achieving adequate knowledge transfer, and the creation of a consensus and innovation space. Lastly, the requirement setting is an issue, as there is a conflict of interest between the industry and the local government in who should set the requirements on how the future mobility system should look.
The association between the presence of fat mass and obesity-associated gene (FTO) and the incidence of obesity in Iraqi persons in Holy Kerbala

Obesity is regarded nowadays as one of the worldwide medical and psychosocial problem so that many researches had been dealt with the underlying causes of resistant obesity and increased bodymass index “BMI”. Recent data demonstrate the strong association between the presence of obesity with speci ic gene called fat mass and obesity associated gene (FTO). Many single nucleotide polymorphisms (SNPs) was detected that are discovered that closely related to the increased incidence of obesity among populations, notably rs9939609 and rs17817449 SNPs. To evaluate the presence of these SNPs as a predisposing factor in obese persons with BMI exceeds 30. A 100 obese persons were selected randomly along with 50 bodyitted people as a control group. Molecular detection of these SNPs was done by RT-PCR followed by statistical analysis. there was signi icant increase in expression of AA genotype of FTO rs9939609 SNP in obese persons in comparison to nonobese group (0.60 ± 0.04 versus 0.28 ± 0.06 respectively at P > 0.002) and signi icant increase in expression of GG genotype of FTO rs1781744 SNP in obese persons in comparison to non-obese group 0.59 ± 0.04 versus 0.22 ± 0.05 respectively at P > 0.001).
Self-Injectable Adrenaline for Anaphylactic Emergencies: Effectiveness of Epipen and Anapen - Are they Fit for Purpose - Evidence to Date

Volume 3 • Issue 1 • 1000116 J Aller Ther ISSN:2155-6121 JAT an open access journal Life-threatening anaphylactic emergencies are largely unpredictable. Adrenaline is widely accepted as first-line therapy for anaphylaxis, due to its physiological effects in reversing symptoms of anaphylaxis and with studies showing both reductions in morbidity and mortality associated with its administration [1-4]. Anaphylaxis can prove fatal, therefore learning how to use an adrenaline auto-injector is crucial for people with allergies and parents of children who have previously suffered from anaphylaxis. Such people must carry an adrenaline autoinjector with them at all times for administration when required. It is surprising that there are currently no internationally accepted criteria, including International Organization of Standards or other governmental regulatory requirements to benchmark the performance of adrenaline auto-injectors under standard conditions as there are for insulin pen injectors [5,6].
Laparoscopic assisted colonotomy suture using evertion and inversion techniques in goats

Laparoscopic assisted colonotomy suture using evertion and inversion techniques in goats M. J. Eesa, F. H. Khalaf and A. F. Ali College of Veterinary Medicine\ University of Baghdad College of Veterinary Medicine\ University of Diyala Abstract The aim of the study was to investigate colonotomy via hand assisted laparoscopy device and to evaluate the closure by using Connell's and horizontal mattress suture technique. Twelve adult healthy local breed goats were used. They were divided randomly into two equal groups, Connell group and horizontal mattress group. The operations were done under the effect of general anesthesia using xylazine 2% (0.05 mg/kg B.W.) and ketamine 5% (3mg/ kg B.W.) injected intramuscularly together. The enterotomy incision was closed by Connell's pattern in Connell's group and by interrupted horizontal mattress technique in horizontal mattress group using polyglycolic acid suture material (No.0) after exteriorized of part of colon laparoscopically. Each group was divided into two equal subgroups depended on follow up of histopathological examination at a periods of 5 and 15 days postsurgery. The results of clinical examination revealed that the activity and appetite of animals were return early to the normal level, also the physical findings returned to the normal level value with a short time after operation in both groups. The histopathological findings of two groups appeared that there was on an inflammatory phase at a period of 5 days post operation, but the granulation tissue and collagen fiber formation was more prominent in horizontal group compared with Connell's group, while at the 15 days post operation in both groups revealed that a granulation tissue in the incision site which covered by epithelial layer with thick fibrous connective tissue and presence of myofibroblast at the incision site. This indicated that the wound was in a mature phase which was clear in horizontal group than in the Connell's group.
Hansenula anomala Fungemia: A Case Report and Review of the Literature

Infection secondary to Hansenula anomala is a rare occurrence, with few reports coming out of the United States. In this study, we report a case of Hansenula anomala fungemia in a patient with non-small cell lung cancer, who was successfully treated with an echinocandin, and review the literature regarding this pathogen.
Parental involvement in education : a preliminary study of the lived experiences of parents in BC

Parents’ involvement in their children’s schooling (PI) has become an established norm in Western society. However, because of the way parents are pressured and positioned within the school system with traditional (TPI) and formalized (FPI) models of involvement, some proponents argue for different and deeper relationships between parents and schools with collaborative (CPI) models. In British Columbia, the current government has proposed through the introduction in 2011 of the BC Education Plan (BCED Plan), that parents in the province could in the future be working in “partnership” with teachers through individualized learning for students. Through the lens of phenomenology, the lived-experiences and beliefs about education and PI of a diverse selection of participants is explored in order to better understand what parents themselves want for their children and what they are trying to achieve through connections to teachers and schools. Conclusions and recommendations about the nature of PI discourse and the future of BCED Plan are offered.
The Pathophysiology of Patellofemoral Pain

Patients with patellofemoral pain represent a significant challenge to the orthopaedic community. The origin of patellofemoral pain can be directly traced to supraphysiologic mechanical loading and chemical irritation of nerve endings, denoting loss of tissue homeostasis. The persistent biologic cascade of cytokine production can lower the load-acceptance capacity of soft tissues and activate painful osseous remodeling. Activities of daily living can become supraphysiologic loads to sensitized patellofemoral tissues, resulting in chronic reactivation of tissue inflammation. The principles of treatment in most patients with patellofemoral pain consist of protection of sensitive tissues from excessive loading, appropriate antiinflammatory therapy, and nonirritat-ing rehabilitation.
Bronchoscopic Valor in Exacerbations of Chronic Bronchitis: A Tale of Bugs and Drugs

T here is a distressingly high rate of treatment failure in acute exacerbations of chronic bronchitis or chronic obstructive pulmonary disease (COPD). Failure rates of 13% to 33% have been reported within 2 to 4 weeks of initial treatment, a deﬁnitely unsatisfactory therapeutic response. 1,2 Treatment failures could be related to several reasons, such as misdiagnosis (eg, pulmonary embolism) and untreatable causes of exacerbations (eg, viral infection). 3–5 With half of the exacerbations attributable to bacterial infection, and with increasing prevalence of antibiotic resistance among these bacteria, it is a reasonable hypothesis that one cause of treatment failure in exacerbations is persistence of bacteria. 6 Persistent bacteria could sustain increased airway inﬂammation and consequently the symptoms of exacerbation. 7,8 However, there is little data to support such a clinical scenario. The study by Baughman et al 9 is an attempt to determine if indeed bacterial persistence is a cause of nonresolution of exacerbations (Baughman). It is a valiant attempt,
Trend and Seasonality in Admission and Outcome of Low Birthweight Infants in Gwagwalada -Abuja,Nigeria

Background : Low birthweight is an important contributor to neonatal morbidity and mortality. Various interventions have been instituted toward the reduction in the incidence of low birthweight deliveries and a dmissions. Knowledge of the current trend and seasonality in low birthweight admission is required in the control of the condition. Objectives: To determine the trend and seasonality in admission and outcome of low birthweight deliveries. Methods : Retrospective review of records of babies admitted into the Special Care Baby Unit of University of Abuja Teaching Hospital, with birthweights below 2500 grams over a 5-year period, from January 2006 through December, 2010, was undertaken and the data obtained were analyzed using Epi Info version 3.5. 2 software. A pvalue of <0.05 was set as point of statistical significance. Results: A total of 4358 babies were admitted into the Special Care Baby Unit during the
Medicine in Philately Hematology and Oncology with Stamps

The importance given to blood and the understanding of cancer are the two oldest features of medical history. These two concepts are combined in our current description as hematologic oncology. Today the three main types of blood cancer are known as lymphoma, leukemia and multiple myeloma. Each varies slightly in terms of treatment, prognosis and symptoms. Beginning from the discovery of blood circulation and blood grouping, with many new techniques in diagnosis and treatment modalities; the approach to hematology and oncology evolved a lot. This paper provides an overview to the main historical aspects of hematology and leukemia through philately.
Sex of Target and Sex of Subject Effects on the Perception of 25, 45, 65, and 85 Year Olds

ABSTRACT In a completely between subjects design 80 male and 80 female undergraduates evaluated targets which were male or female and 25, 45, 65, or 85 years old, on the Aging Semantic Differential (ASD; Rosencranz & McNevin, 1969). Findings indicated that older targets were rated less positively than younger targets on two of the three ASD dimensions and that Target Age × Target Sex × Subject Age interactions were significant for two of the dimensions. These results replicate the target age (between subjects) effects reported by O'Connell and Rotter (1979) but not those which involved target sex (within subjects) and subject sex. It was concluded that a) subject sex and target sex affect perceptions of targets of different ages elicited from young subjects and b) between subjects versus within subjects designs produce different characterizations of such targets. RÉSUMÉ Au cours d'une recherche conçue sur un modèle strictement intersubjectif, 80 étudiants et 80 étudiantes du premier cycle ont porté une appréciation sur des hommes et des femmes (cibles) âgés de 25, 45, 65 et 85 ans, à l'aide de la différentielle sémantique sur le vieillissement (Rosencranz & McNevin, 1969: Aging Sematic Differential/ASD/). Les résultats indiquent que les cibles plus âgées ont été moins bien cotées que les plus jeunes selon deux des trois dimensions de l'ASD, et que les interactions “Âge de la cible × Sexe de la cible × Âge du sujet” sont significatives pour deux des dimensions. Ces résultats confirment les effets de l'âge des cibles (entre sujets) rapportés par O'Connell et Rotter (1979), mais non pas ceux qui proviennent du sexe des cibles (entre sujets) ni du sexe des sujets. On en conclut (a) que le sexe du sujet et celui de la cible affectent la perception des cibles d'âge différent, chez les sujets jeunes et (b) que le plan de recherche intersubjectif évoque des caractérisations différentes de celles que l'on obtient à partir d'un plan de recherche basé sur la réciprocité.