Miracle-dz/UniFAR-FTUs huggingface dataset:
Unraveling Financial Fraud: The Role of the Board of Directors and External Advisors in Conducting Internal Investigations Rebecca Files The University of Texas at Dallas

When faced with allegations of wrongdoing, the Securities and Exchange Commission (SEC) and Department of Justice (DOJ) encourage firms to cooperate by engaging independent leaders and external advisors to conduct internal investigations, and this study examines the role of these parties on investigation outcomes. After controlling for investigation leader determinants, we find that firms whose internal investigations are led by independent teams are more likely to retain outside advisors, have a 38% higher likelihood of CEO turnover, face a 36% lower likelihood of an SEC sanction, and receive smaller SEC fines. The independent leader’s effect on CEO turnover and SEC enforcement is partially mediated by the involvement of external advisors. Our findings extend prior work by demonstrating that the SEC rewards cooperation, and they suggest that appointing independent groups to lead internal investigations protects the firm, at the expense of the CEO, following accounting fraud.
Keep Working and Spend Less? Collective Childcare and Parental Earnings in France

I leverage the staggered expansion of subsidized childcare facilities across municipalities in response to a succession of national plans to investigate the effect of collective childcare on parents’ labor outcomes and childcare choices in France between 2007 and 2015. These plans did not lead to any substantial change in parents’ labor outcomes or in paid parental leave take-up. Instead, these collective childcare expansions crowded out more costly formal childcare solutions, such as childminders or at-home childcare. These crowding-out effects highlight a downside of family policy strategies that foster the coexistence of multiple childcare arrangements.
Towards the Standardization of Multi-Agent Systems Architectures: An Overview

Agents are everywhere. One can find intelligent agents, information agents, mobile agents, personal assistant agents, and so on. At this point, one could start asking if it is possible to make some sense of this apparent anarchy: What is it that makes an agent? Is there something that agents have in common? How can one organize them to carry out tasks? Fortunately, we are not the first to ask these questions, since researchers have already defined some helpful notions. Firstly, authors have acknowledged that agents are entities within an environment, and that they can sense and act (not necessarily in that order). This means that agents are not isolated entities, and that they are able to communicate and collaborate with other entities. Simply put, agents that are not able to work together with other agents (humans included) are destined to become virtually useless. Once agents are ready for collaboration, they will need to find other agents they need to collaborate with. Such a task is easy if they know exactly which agents to contact at which location. However, our everyday human experience has shown us that such a static setting is very unlikely to exist: people are usually on the move and they are not always readily available to interact with others. The same holds true for dynamic multi-agent systems: agents need support to find other agents. Such are the motivations pursued by research groups working on the standardization of dynamic collaborative multi-agent systems. Some of these groups are the Foundation for Intelligent Physical Agents (FIPA), the Object Management Group (OMG), the Knowledge-able Agent-oriented System (KAoS), and the General Magic group. This article briefly describes these groups' efforts toward the standardization of multi-agent systems architectures, and sketches early works to define a multi-agent systems architecture at the University of Calgary. However, the main objective of this article is to give the reader a basic overview of the background and terminology in this exciting area of research.
Be(e)coming pollinators: Beekeeping and perceptions of environmentalism in Massachusetts

In an era of mass extinction and biodiversity crisis, it is increasingly crucial to cultivate more just and inclusive multispecies futures. As mitigation and adaption efforts are formed in response to these crises, just transitions forward require intentional consideration of the hybrid entanglement of humans, human societies, and wider landscapes. We thus apply a critical hybridity framework to examine the entanglement of the pollinator crisis with the cultural and agricultural practice of hobbyist beekeeping. We draw on ethnographic engagements with Massachusetts beekeepers and find apiculture to be widely understood as a form of environmentalism—including as both a mitigation to and adaptation for the pollinator crisis. Illustrating how power-laden socioecological negotiations shape and reshape regional environments, we then discuss how this narrative relies on the capitalistic and instrumental logics characteristic of Capitalocene environmentalisms. These rationalities, which obscure the hybridity of landscapes, consequently increase the likelihood of problematic unintended consequences. Also present, however, is a deeper engagement with hybrid perspectives, with some beekeepers even offering pathways toward inclusive solutions. We conclude that if more just and biodiverse futures are to be realized, beekeeping communities must foster increasingly hybrid visions of apiculture as situated within socioecological and contested landscapes.
Effect of physiotherapy rehabilitation on stage 4 avascular necrosis of femur following pyogenic arthritis: a case report

Avascular necrosis of the femur is a painful condition marked by a disruption in the blood supply to the femoral head, which causes the femur bone to distort; characterized by pain and restriction of movements at the affected joint with a limp. The study aimed to provide a case of nontraumatic stage-4 avascular necrosis of the left femoral head with gross 40-degree adductor deformity. In this report, a 27-year-old female complained of pain in her left hip joint and difficulty in walking. She was a known case of pyogenic arthritis with 5 cm of true shortening on her left side and a gross 40-degree adduction deformity of her left leg. According to Ficat and Arlet's grading system, an X-ray showed stage-4 avascular necrosis of the left femoral head. For this, she was managed with adductor tenotomy, medications, and physiotherapy management with a one-month rehabilitation protocol. A physiotherapy intervention consists of a non-weight-bearing phase and a weight-bearing phase. At the time of her physiotherapy discharge, the patient experienced alleviation from symptoms and achieved functional mobility that she had previously been unable to tolerate owing to pain. As a result, physical therapy rehabilitation has been proved to be highly beneficial. This case study concludes that multidisciplinary team including medical, surgical approach and physiotherapy rehabilitation played a vital role in reducing pain; enhance muscle strength, functional independence, and quality of life in patients with stage 4 avascular necrosis of the femur followed by pyogenic arthritis.
Biopsychosocial approach to understanding determinants of depression among men who have sex with men living with HIV: A systematic review

Introduction Men who have sex with men (MSM) living with HIV are more likely to be depressed than MSM without HIV. The AIDS epidemic will not end if the needs of people living with HIV and the determinants of health are not being addressed. Compared to HIV individuals without depression, depressed HIV individuals have worse clinical outcomes and higher mortality risk. Depression is caused by a complex combination of social, psychological, and biological variables. This systematic review, thereby motivated by the need to address this gap in the literature, aims to articulate determinants of depression among MSM living with HIV according to the biopsychosocial approach. Methodology We systematically searched four databases from 2011 to 2021. We searched for observational studies on determinants of depression among MSM living with HIV. The outcome is depression based on the categorical or numerical outcome. Two reviewers independently extracted data and assessed study risks of bias. Any disagreements are consulted with the third reviewer. Results We identified 533 articles, of which only eight studies are included. A total of 3,172 MSMs are included in the studies. We found the determinants of depression and categorized them according to biological, psychological, and social approaches. Conclusion The determinants of depression with the strongest evidence across studies were enacted HIV-related stigma, unemployment, sleep disturbance, current smoker, black ethnicity, born overseas, ART initiation, and access to mental health care. Despite weaker evidence, the other relevant determinants to be included were older age, internalized stigma, self-efficacy, and social support. Efforts to improve or prevent depression among MSM living with HIV could benefit from addressing the determinants of depression based on the biopsychosocial approach immediately after HIV diagnosis. Integrating mental health screening and care into HIV treatment settings would strengthen HIV prevention and care outcomes and improve access to mental healthcare.
SARS-CoV-2 infecting endothelial cells, biochemical alterations, autopsy findings and outcomes in COVID-19, suggest role of hypoxia-inducible factor-1

Researchers around the world have experienced the dual nature of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), 'tragically lethal in some people while surprisingly benign in others'. There have been congregating studies of the novel coronavirus disease (COVID-19), a disease that mainly attacks the lungs but also has mystifying effects on the heart, kidneys and brain. Researchers are also gathering information to ascertain why people are dying of COVID-19, whether it is solely a respiratory disorder, a coagulation disorder or multi-organ failure. Alterations in laboratory parameters like lactate, ferritin and albumin have been established as risk factors and are associated with outcomes, yet none have not been sub stantiated with a scientific biochemical rationale. SARSCoV-2 affects the alveolar type II epithelial cells which significantly disturbs its surfactant homeostasis, deprives Na,K-ATPase of ATP, thereby disturbing the alveolar lining fluid which then gradually decreases the alveolar gaseous exchange initiating the intracellular hypoxic conditions. This activates AMP-activated kinase, which further inhibits Na,K-ATPase, which can progressively cause respiratory distress syndrome. The virus may infect endothelial cell (EC) which, being less energetic, cannot withstand the huge energy requirement towards viral replication. There - fore glycolysis, the prime energy generating pathway, must be mandatorily upregulated. This can be achieved by Hypoxia-inducible factor-1 (HIF-1). However, HIF-1 also activates transcription of von Willebrand factor, plasminogen activator inhibitor-1, and suppresses the release of thrombomodulin. This in turn sets off the coagulation cascade that can lead to in-situ pulmonary thrombosis and micro clots. The proposed HIF-1 hypothesis justifies various features, biochemical alteration, laboratory as well as autopsy findings such as respiratory distress syndrome, increased blood ferritin and lactate levels, hypoalbuminemia, endothelial invasion, in-situ pulmonary thrombosis and micro clots, and multi-organ failure in COVID-19.
Challenges of senior 8-year-program medical students’ scientific research in China

Abstract Among the diverse medical education systems in China, the 8-year program is dedicated to cultivating physician scientists. Although the research ability of senior students in 8-year medical programs is a pivotal quality, it remains unclear. This study aimed to clarify the current status and challenges of students’ research experience, abilities, and outputs. A multicenter cross-sectional study was conducted in 5 medical schools in northern China. Electronic questionnaires were sent to 235 randomly chosen fifth-grade or sixth-grade 8-year-program medical students. A total of 211 responses were collected and analyzed using SPSS 22.0. Only 13.3% of participants chose research as their future career goal. Students generally felt that conducting research was stressful and difficult. The greatest obstacle was a lack of time due to heavy workloads. The 2 major motivations for research were graduation and/or future employment (75.8%) and research interest (24.2%). More than half of the students (142, 67.3%) had research experience by the time of the survey, among whom 84 students already had research outputs. A higher proportion of students with outputs was motivated by the requirements for graduation or employment compared to students without outputs (71.4% vs 55.2%, P = .046). Senior 8-year-program medical students in China generally had high pressure to conduct research and devoted their efforts to overcome these challenges. More guidance and novel encouragement to enhance students’ initiative and interest in research could be provided by medical schools and educators in the future.
Subconcussive changes in youth football players: objective evidence using brain vital signs and instrumented accelerometers

Abstract Brain vital signs, measured by EEG, were used for portable, objective, neurophysiological evaluation of cognitive function in youth tackle football players. Specifically, we investigated whether previously reported pre- and post-season subconcussive changes detected in youth ice hockey players were comparably detected in football. The two objectives were to: (i) replicate previously published results showing subconcussive cognitive deficits; and (ii) the relationship between brain vital sign changes and head-impact exposure. Using a longitudinal design, 15 male football players (age 12.89 ± 0.35 years) were tested pre- and post-season, with none having a concussion diagnosis during the season. Peak latencies and amplitudes were quantified for Auditory sensation (N100), Basic attention (P300) and Cognitive processing (N400). Regression analyses tested the relationships between these brain vital signs and exposure to head impacts through both number of impacts sustained, and total sessions (practices and games) participated. The results demonstrated significant pre/post differences in N400 latencies, with ∼70 ms delay (P < 0.01), replicating prior findings. Regression analysis also showed significant linear relationships between brain vital signs changes and head impact exposure based on accelerometer data and games/practices played (highest R = 0.863, P < 0.001 for overall sessions). Number of head impacts in youth football (age 12–14 years) findings corresponded most closely with prior Junior-A ice hockey (age 16–21 years) findings, suggesting comparable contact levels at younger ages in football. The predictive relationship of brain vital signs provided a notable complement to instrumented accelerometers, with a direct physiological measure of potential individual exposure to subconcussive impacts.
Associations between Low to Moderate Consumption of Alcoholic Beverage Types and Health Outcomes: A Systematic Review

Abstract Aims There is limited research comparing light to moderate wine, beer and spirits consumption and their impact on long-term health. This systematic review aims to investigate the studies published in the past 10 years and qualitatively assess the similarities and differences between the three main beverages, when consumed at a low to moderate level, for their associations with various health outcomes. Methods A systematic search was conducted for comparative studies published in English language (2010 to mid-2021) of beverage-specific low to moderate alcohol consumption associated with all-cause mortality, cancer, cardiovascular disease and diabetes mellitus type II. Results The search yielded a total of 24 studies (8 meta-analyses; 15 prospective studies and 1 pooled analysis). Overall, most studies showed similar associations of different alcoholic beverages with chronic conditions, including all-cause mortality, many types of cancer, cardiovascular disease and diabetes mellitus type II. Not all data are consistent. Some studies show more beneficial or detrimental effects of wine than other beverage types, whereas other studies show such effects for other beverages. Conclusion Moderate consumption of one specific alcoholic beverage (wine, beer or spirits) may not be consistently associated with higher or lower risks for common health outcomes as compared with moderate consumption of any of the other alcoholic beverages.
Preliminary application of native Nephila edulis spider silk and fibrin implant causes granulomatous foreign body reaction in vivo in rat’s spinal cord

After spinal cord injury, gliomesenchymal scaring inhibits axonal regeneration as a physical barrier. In peripheral nerve injuries, native spider silk was shown to be an effective scaffold to facilitate axonal re-growth and nerve regeneration. This study tested a two-composite scaffold made of longitudinally oriented native spider silk containing a Haemocomplettan fibrin sheath to bridge lesions in the spinal cord and enhance axonal sprouting. In vitro cultivation of neuronal cells on spider silk and fibrin revealed no cytotoxicity of the scaffold components. When spinal cord tissue was cultured on spider silk that was reeled around a metal frame, migration of different cell types, including neurons and neural stem cells, was observed. The scaffold was implanted into spinal cord lesions of four Wistar rats to evaluate the physical stress caused on the animals and examine the bridging potential for axonal sprouting and spinal cord regeneration. However, the implantation in-vivo resulted in a granulomatous foreign body reaction. Spider silk might be responsible for the strong immune response. Thus, the immune response to native spider silk seems to be stronger in the central nervous system than it is known to be in the peripheral body complicating the application of native spider silk in spinal cord injury treatment.
Identification of C-T novel polymorphism in 3rd exon of OsSPL14 gene governing seed sequence in rice

Recently food shortage has become the major flagging scenario around the globe. To resolve this challenge, there is dire need to significantly increase crop productivity per unit area. In the present study, 24 genotypes of rice were grown in pots to assess their tillering number, number of primary and secondary branches per panicle, number of grains per panicle, number of grains per plant, and grain yield, respectively. In addition, the potential function of miR156 was analyzed, regulating seed sequence in rice. Furthermore, OsSPL14 gene for miR156 was sequenced to identify additional mutations within studied region. The results demonstrated Bas-370 and L-77 showed highest and lowest tillers, respectively. Bas-370, Rachna basmati, Bas-2000, and Kashmir Basmati showed high panicle branches whereas, L-77, L-46, Dilrosh, L-48, and L-20 displayed lowest panicle branches. Bas-370 and four other studied accessions contained C allele whereas, L-77 and 18 other investigated accessions had heterozygous (C and T) alleles in their promoter region. C-T allelic mutation was found in 3rd exon of the OsSPL14 gene. The sequence analysis of 12 accessions revealed a novel mutation (C-T) present ~2bp upstream and substitution of C-A allele. However, no significant correlation for novel mutation was found for tillering and panicle branches in studied rice accessions. Taken together present results suggested novel insight into the binding of miR156 to detected mutation found in 3rd exon of the OsSPL14 gene. Nevertheless, L-77, L-46, Dilrosh, L-48, and L-20 could be used as potential breeding resource for improving panicle architecture contributing yield improvement of rice crop.
Knowledge, risk perception, and prevention preparedness towards COVID-19 among a cross-section of animal health professionals in Nigeria

Introduction the on-going COVID-19 pandemic caused by the SARS-CoV-2 virus has imposed serious public health and economic threats on the entire world population. The SARS-CoV-2 has been identified from both domestic and wild animals constituting a threat to humans since most apparently healthy animals may potentially infect and cause the disease in humans, especially Animal Health Professionals (AHPs) who come directly in contact with animals. These professionals such as veterinarians play important roles among the One Health team in controlling the pandemic. This survey was conducted to assess the knowledge, risk perception, and prevention behaviors of AHPs in Nigeria who are important personnel in the control of emerging and re-emerging zoonotic and infectious diseases. Methods an online-based epidemiological cross-sectional pre-tested questionnaire survey was carried out from April to May 2020. A total of 427 AHPs joined this survey. Descriptive statistics, chi-square test, and binary logistic regression model were used to analyze the data collected. Results the respondents have a mean knowledge score of 7.34 ± 2.05 (from a total possible score of 11) with the majority (66.7%, n = 285) having satisfactory knowledge scores on COVID-19. A high proportion (240/353) of respondents reported bats to be the major wildlife incriminated in the transmission of the COVID-19 virus though other animals reported were tiger, monkey, lion, and pangolin. At least, a quarter 131 (30.7%) of respondents perceived that visiting live animal markets is of high zoonotic risk to the spread of coronavirus. Most respondents reported hands washing and sanitizing after handling animals, and using personal protective equipment when handling suspected animals. At p<0.05; respondents' age, marital status, professional status, and geopolitical zone were significantly linked with satisfactory knowledge. Veterinarians (OR=0.40; 95%CI: 0.22–0.75) were thrice less likely to possess unsatisfactory knowledge of COVID-19 than laboratory technologists. Conclusion participants in this survey have a satisfactory level of COVID-19 knowledge and good mitigation measures instituted while working at their stations. However, AHPs need more enlightenment about the various zoonotic risk pathway contributing to the transmission of COVID-19.
Mirogabalin as a Novel Gabapentinoid for the Treatment of Chronic Pain Conditions: An Analysis of Current Evidence

Neuropathic pain is a challenge for physicians to treat and often requires a multimodal approach with both pharmacologic and lifestyle interventions. Mirogabalin, a potent, selective ligand of the α2δ-1 and α2δ-2 subunits of voltage-gated calcium channels (VGCCs), provides analgesia by inhibiting neurotransmitter release at the presynaptic end of the neuron. Mirogabalin offers more sustained analgesia than its gabapentinoid counterparts in addition to a wider safety margin for adverse events. Recent clinical trials of mirogabalin have demonstrated both efficacy and tolerability of the drug for the treatment of diabetic peripheral neuropathic pain and postherpetic neuralgia, leading to its approval in Japan. While still not yet FDA approved, mirogabalin is still in its infancy and offers potential into the treatment of neuropathic pain and its associated comorbidities.