Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-Reported Health-Related Quality of Life and Residual Symptoms among Virologically Suppressed People Living with HIV in the Era of Single-Tablet Regimens in Taiwan: A Cross-Sectional Study

This study assessed the health-related quality of life (HRQoL) and residual symptom burden among virologically suppressed people living with human immunodeficiency virus (HIV) (PLWH) using a single-tablet regimen in Taiwan. This cross-sectional study administered a self-reported online survey between July and October 2021 to anonymised virologically suppressed PLWH aged ≥20 years. Demographic, HIV-related variables, EuroQol-5-dimensions (EQ-5D), visual analogue scale (VAS), and HIV Symptom Index were analysed. Bivariate analyses were performed to compare HRQoL differences between PLWH and non-PLWH. Among 120 PLWH, 80.9% had HIV diagnosis for <15 years, median antiretroviral therapy (ART) duration of 7.0 years (Q1–Q3:4.0–11.0), and 62.5% had ≥1 comorbidity. The most common comorbidities were depression (26.7%) and hyperlipidaemia (15.8%). About one-fifth of PLWH received constant family support (25.8%) and peer support (21.7%). Married individuals or individuals with higher incomes had significantly better family support status. There was no significant difference across the five dimensions between PLWH and non-PLWH. PLWH perceived being bothered by fatigue/lack of energy (63.3%), sleep difficulties (63.3%), feeling sad/low/unhappy (51.7%), and appearance changes (51.7%). PLWH could achieve similar HRQoL as non-PLWH with stable treatment, highlighting an opportunity to focus on person-centred holistic care beyond HIV, especially on the psychological aspect, for the best possible HRQoL for PLWH.
ROS Scavenging Effect of Selected Isoflavones in Provoked Oxidative Stress Conditions in Human Skin Fibroblasts and Keratinocytes

Isoflavones, belonging to polyphenolic compounds, show structural similarity to natural estrogens, and in this context, they have been extensively studied. Some of them are also applied as cosmetic additives; however, little is known regarding their effects on skin cells. In this investigation, common isoflavones, including genistein, daidzein, glycitein, formononetin, and biochanin A, as well as coumestrol, were evaluated for antioxidant activity and their impact on human skin fibroblasts and keratinocytes. Antioxidant effects were assessed using DPPH, ABTS, and FRAP tests, and the ability to scavenge reactive oxygen species (ROS) was tested in cells with H2O2-provoked oxidative stress. The impact on the activity of antioxidant enzymes (SOD, CAT, GSH) and lipid peroxidation (MDA) was also explored. As shown by Alamar Blue and neutral red uptake assays, the compounds were not toxic within the tested concentration range, and formononetin and coumestrol even demonstrated a stimulatory effect on cells. Coumestrol and biochanin A demonstrated significant antioxidative potential, leading to a significant decrease in ROS in the cells stimulated by H2O2. Furthermore, they influenced enzyme activity, preventing depletion during induced oxidative stress, and also reduced MDA levels, demonstrating protection against lipid peroxidation. In turn, genistein, daidzein, and glycitein exhibited low antioxidant capacity.
Lithology and radiolarian age of the Ryokami‐yama Chert Formation in eastern Mt. Ryokami: Possible décollement zone in Permian pelagic sequence in mid‐Mesozoic accretionary complexes of Southwest Japan

Uppermost Permian–lowermost Triassic siliceous claystone is well‐known as being a possible décollement zone in accretionary processes of mid‐Mesozoic accretionary complexes in Southwest Japan; meanwhile, fewer studies have focused on other décollement zones in Permian pelagic sequences. The Ryokami‐yama Thrust in the Southern Chichibu terrane, eastern Mt. Ryokami, Kanto Mountains, has been considered an out‐of‐sequence thrust and might show a former décollement zone in the formation's Permian pelagic sequences. This study shows the Permian pelagic sequences (lithology and radiolarian age) of the Ryokami‐yama Chert Formation on the Ryokami‐yama Thrust. The basal part of the Ryokami‐yama Chert Formation consists of pale‐green basaltic tuff breccia and overlying red‐ocher thick‐bedded chert intercalating dolomites. The red‐ocher thick‐bedded chert yielded radiolarians of the Pseudoalbaillella lomentaria Range‐Zone of the Sakmarian (Cisuralian: lower Permian). Compilation of the Permian pelagic sequences of the mid‐Mesozoic accretionary complexes in previous studies indicates that the bases of the Permian chert of many geologic units are concentrated in the Pseudoalbaillella lomentaria Range‐Zone. The following hypothesis is suggested here: the basaltic rock underlying the Sakmarian chert acted as a décollement zone in the Permian pelagic sequences of some geologic units of the mid‐Mesozoic accretionary complexes.
Soil water content and temporal stability in an arid area with natural and planted grasslands

Soil water content (SWC) is a key factor for successful vegetation restoration in arid and semiarid regions, and vegetation has significant influences on the spatial patterns and temporal dynamics of SWC. The aim of this study was to investigate the temporal stability of SWC under different restored grasslands in an arid hilly area of Central China. SWC was measured in the 0‐ to 300‐cm soil profile in the natural grassland (Stipa capillata) and three typical planted grasslands (Medicago sativa, Agropyron cristatum, and Caragana korshinskii) over two growing seasons (from June to October 2015 and 2016) under natural rainfall conditions. The results showed that the mean SWC in the natural grassland was approximately 30% higher than those in the planted grasslands. The SWC consumption of the planted legume grasslands in the deepest soil layers (below 200 cm) was higher than that of the natural grassland, owing to the deep root system of the legumes. Both natural and planted grasslands had low SWC temporal stability in the top soil layers (0–50 cm), whereas more stable conditions were gradually observed with increasing the soil depth. The mean value of the mean relative differences of SWC in natural grassland (ca. 15%) was lower than that in the planted grasslands (A. cristatum grasslands) and much lower than that in the scrubland, highlighting the stronger temporal stability of SWC in the natural grassland. In conclusion, natural grassland could maintain higher and stable SWC and is recommended to be used for achieving sustainable vegetation restoration in arid and semiarid regions.
Impact of Recasts in Improving English Essay Writing Skills of Pakistani College-level EFL Learners

The role of feedback is considered positive in improving English writing skills. The article aims to examine the impact of recasts on the essay-writing skills of Pakistani L2 learners and ascertain the perception of the learners towards using recast-based feedback on their essay writing skills. The study employed an experimental research design, with 50 college-level students divided into two groups: experimental (n = 25) and control (n = 25). For eight weeks, the experimental group received both traditional and recast-based linguistic feedback on their essay writing tasks, while the control group received just traditional input. Pre and post-tests were conducted before and after eight weeks' (24-hour) treatment to determine differences between the mean scores. A subset of participants was selected for semi-structured interviews to discuss their perceptions and experiences with the recast feedback. The outcomes indicated that the treatment group outperformed the control group and that the subjects of the study perceived recast-based feedback as a positive activity that enhances motivation, confidence, and autonomy. The study has pedagogical and academic implications.
Vitiligo: concomitant autoimmune and allergic diseases

Introduction: The aim of the study was to determine its epidemiology and clinical aspects. Vitiligo is a chronic skin condition caused by progressive cutaneous hypomelanosis. Aim: As considerable progress has been made in understanding of the pathogenesis of vitiligo and its classification as an autoimmune disease, the paper pays particular attention to coexisting autoimmune or atopic diseases. Material and methods: The study included 55 patients attending the Diagnostic and Treatment Center of Skin Diseases in Lodz. Data were collected during outpatient dermatological consultation. Results: The most common type of vitiligo was nonsegmental (85.5%) followed by segmental (12.7%) and unclassified (2.1%). The first skin lesions were mostly located on the hands (45.5%) and face (38.2%). Older patients with higher body mass index tended to demonstrate a higher body surface area. Of the patients, 63.6% demonstrated an autoimmune or atopic comorbidity, the most common of which were type 1 diabetes mellitus (18.2%), psoriasis (16.4%) or Hashimoto’s thyroiditis (14.5%). Location on the face was associated with a significantly greater incidence of autoimmune or atopic co-morbidities. Conclusions: A facial location may serve as a predictive factor for other autoimmune or atopic diseases in vitiligo patients. Determining clinical factors in vitiligo patients which could be associated with a higher risk of autoimmune comorbidities may allow for their early diagnosis and suitable treatment.
Examining the Association between Psychosocial Support and Resilience in People Diagnosed with Infertility

Infertility and infertility treatment cause great suffering for individuals and couples, particularly when they lack psychosocial support and resilience. The purpose of the study was to examine the association between the role of psychosocial support and resilience in 152 infertility patients at 2 hospitals in North Vietnam. Participants completed the Connor–Davidson Resilience Scale (CD-RISC) and The Multidimensional Scale of Perceived Social Support (MSPSS). The findings demonstrated that resilience in infertility patients, both generally and specifically in women, was significantly predicted by support from friends and family. Meanwhile, psychosocial support sources have no effect on resilience in infertile men. The findings highlight the importance of psychosocial support for people diagnosed with infertility in the Vietnamese cultural context.
Toward Recognizing the Prehistoric Butchery of Frozen Meat: An Archaeological Experiment and Stone Tool Microwear Analysis

ABSTRACT Prehistoric humans occupied cold environments for more than one million years without the controlled use of fire. Processing frozen meat may have been a regular occurrence. In order to explore whether this behavior is present in the archaeological record, archaeologists must first understand whether the butchery of frozen meat leaves diagnostic traces of microwear on stone tools. We present an experiment that investigates what sorts of micro-traces are left on replica stone tools used for butchering frozen versus raw meat. Our results indicate that polish of similar brightness and texture forms on specimens used to slice both frozen and unfrozen meat, but that there are differences in the extent of polish formation away from the tool edge, damage frequency, and damage type. These experimental results can be used as a model to recognize frozen and unfrozen meat butchery on artifacts, which in turn has implications for interpreting archaeological sites.
A novel optimized pre-embedding antibody-labelling correlative light electron microscopy technique

In the intricate environment of a cell, many studies seek to discover the location of specific events or objects of interest. Advances in microscopy in recent years have allowed for high detail views of specific areas of cells of interest using correlative light electron microscopy (CLEM). While this powerful technique allows for the correlation of a specific area of fluorescence on a confocal microscope with that same area in an electron microscope, it is most often used to study tagged proteins of interest. This method adapts the correlative method for use with antibody labelling. We have shown that some cellular structures are more sensitive than others to this process and that this can be a useful technique for laboratories where tagged proteins or viruses, or dedicated CLEM instruments are not available.
Factors Associated with Liver Injury After Intravenous Gamma Globulin Treatment in Children with Kawasaki Disease

Background: The etiology of liver injury in children with Kawasaki disease(KD) is not yet clear.It is common for children who are responded to intravenous gamma globulin (IVIG) therapy to develop liver injury after IVIG treatment. This research is to explore related factors of liver injury after IVIG treatment in children with KD who responded retrospectively to IVIG. Methods: A total of 806 children with KD were included in this analysis. The clinical characteristics, laboratory �ndings, and drug use before IVIG were collected. Difference analysis, ROC curve analysis and logistic regression analysis were performed to obtain possible risk factors for liver injury after IVIG treatment. Results: Among the clinical symptoms of the two groups of children, children with lymphadenopathy had a lower risk of developing liver injury after IVIG treatment(p=0.040),while there were no signi�cant differences in other symptoms. Among laboratory indicators, the liver injury group had higher levels of platelet(PLT),eosinophil(EO) and brain natriuretic peptide(BNP) levels and lower hemoglobin(HB),erythrocyte sedimentation rate(ESR) and prothrombin time(PT) levels before IVIG treatment (p<0.05). There were no signi�cant difference in c-reactive protein(CRP) and Procalcitonin(PCT) (p>0.05). The use of antibiotics, dipyridamole and aspirin doses between two groups had statistically signi�cant differences(p>0.05). Further ROC curve analysis of aspirin dose found the optimal cut-off point of aspirin was 34.7 mg/(k*d)(the 95% CI: 0.504-0.601,p=0.026). The logistic regression analysis showed high-dose aspirin ( ≥ 34.7mg/(kg*d))was a risk factor for liver damage after IVIG treatment in KD children. Further multivariate regression analysis prompted that the use of antibiotics and higher doses of aspirin( ≥ 34.7mg/(kg*d))in the acute phase were independent risk factors for
A Taxonomy of Syntactic Privacy Notions for Continuous Data Publishing

Continuous data publishing aims to anonymise the next publication of changing microdata while preserving privacy. The microdata can change between publications via additions, deletions, insertions, and updates. There are numerous proposals for different database types, adversaries, attacks, and notions. However, many anonymization algorithms include notions of privacy and adversarial models that are specific to the context, with their own terminology and notation. Unfortunately, these proposals are difficult to generalize or translate them to other contexts complicating their understanding and comparison. To address these issues, we propose a taxonomy of anonymization technologies, compare existing solutions, and develop a unifying framework that not only harmonizes concepts and terminology but also notation and nomenclature. We analyze the current state of the art and recent advances in the literature. The analysis enables us to understand the significance and appropriateness of the various proposals in achieving privacy.
Array comparative genomic hybridisation on ﬁrst polar bodies suggests that non-disjunction is not the predominant mechanism leading to aneuploidy in humans

Introduction Aneuploidy (the presence of extra or missing chromosomes) arises primarily through chromosome segregation errors in the oocyte at meiosis I but the details of mechanism by which such errors occur in humans are the subject of some debate. It is generally believed that aneuploidy arises primarily as a result of segregation of a whole chromosome to the same pole as its homologue (non-disjunction). Nonetheless, classical cytogenetic studies suggest that this model does not fully account for the patterns observed in human oocytes. An alternative model (precocious separation of sister chromatids) has thus been proposed, but recurring criticism of this model purports that technical issues may have led to interpretation errors. Materials and methods Array comparative genomic hybridisation (aCGH) was used on 164 human ﬁrst polar bodies to distinguish between whole chromosome (non-disjunction) and chromatid (precocious separation) errors. Results Single chromatid errors were over 11 times more common than whole chromosome errors, consistent with prior classical cytogenetic and ﬂuorescence in situ hybridisation (FISH) studies. Discussion The received wisdom that non-disjunction is the primary mechanism leading to human aneuploidy should be reconsidered.
Current-Induced Magnetization Switching in Light-Metal-Oxide/Ferromagnetic-Metal Bilayers via Orbital Rashba Effect.

The orbital angular momentum (OAM) generation as well as its associated orbital torque is currently a matter of great interest in spin-orbitronics and is receiving increasing attention. In particular, recent theoretical work predicts that the oxidized light metal Cu can serve as an efficient OAM generator through its surface orbital Rashba effect. Here, for the first time, the crucial current-induced magnetic-field-free in-plane magnetization reversal is experimentally demonstrated in CoFeB/CuOx bilayers without any heavy elements. We show that the critical current density can be comparable to that of strong spin-orbit coupling systems with heavy metals (Pt and Ta) and that the magnetization reversal mechanism is governed by coherent rotation in the grains through the second-harmonic and magneto-optical Kerr effect measurements. Our results indicate that light metal oxides can play an equally important role as heavy metals in magnetization reversal, broadening the choice of materials for engineering spintronic devices.
The Association of Coping Strategies with Stress, Anxiety, and Depression, with Mediating Role of Job Satisfaction among Traffic Wardens

The current study aimed to explore the association of coping strategies with stress, anxiety, and depression with the mediating role of job satisfaction among traffic wardens. Participants were taken from the different cities of Punjab Pakistan, such as Faisalabad (N = 39, 21%), Rawalpindi (N = 38, 20.4%), Multan (N = 36, 19.4%), Lahore (N=38, 20.4%) and Gujranwala (N= 35, 18.8%). The current study sample was comprised of 186 traffic wardens. The sample consisted of married (n= 164, 88.2%) and unmarried (n= 22, 11.8%) of the total population. The participant was between 19 - 50 years (M = 34.78, SD = 4.65). A purposive sampling technique was used to collect the data. The variables were assessed through i.e. Demographic Form, Depression, Anxiety, Stress Scale (DASS-21; Lovibond & Lovibond, 1995), translated version by Aslam (2007), Job Satisfaction Survey (JSS; Spector, 1985) translated version by Abbas and Khanam (2016) and Coping Strategies Questionnaire (CSQ; Kausar & Munir, 2004). The results showed coping is the predictor of stress, anxiety, and depression among traffic wardens, with a strong mediating role of job satisfaction. Further, results showed coping has a strong mediating role in job satisfaction. It is concluded that there is a significant association of coping strategies with stress, anxiety, and depression among traffic wardens with mediating role of job satisfaction.
Insights on the Japanese Subduction Megathrust Properties From Depth and Lateral Variability of Observed Ground Motions

Two ground motion prediction equation models for subduction zones have been tested using a public ground motion database of the KiK‐net records obtained by automated processing protocols (Dawood et al., 2016, https://doi.org/10.1193/071214EQS106). The database contains records of more than 700 interface earthquakes that occurred on the Japan subduction between 1998 and 2012. The Zhao et al. (2006, https://doi.org/10.1785/0120050122) ground motion prediction equation was shown to be the best suited model for the region. It was then used as backbone to analyze the variability of ground motion records. The residuals between observed and predicted ground motions have been analyzed to study the spatial variation of the earthquakes' ground motion frequency content on the Japan megathrust. This analysis revealed a depth dependency of generated ground motions consistent with the downdip segmentation proposed for subduction interfaces (Lay et al., 2012, https://doi.org/10.1029/2011JB009133), a regional ground motion dependency that may be related with lateral variations of the mechanical properties of the subduction interface and a high‐frequency radiations drop in the earthquake sequence that preceded the Tohoku‐Oki earthquake Mw 9.0. The regional ground motion dependency suggests the existence of different domains along trench of the Japan subduction megathrust that control the ground motions and the wave radiation patterns of interface earthquakes. The location of their boundaries is consistent with the extension of the rupture of the 2011 Tohoku‐Oki earthquake, with pre‐Tohoku interseismic coupling, and with the free air gravity anomalies.
Student Perceptions of the Complete Online Transition of Two CS Courses in Response to the COVID-19 Pandemic

In this evidence-based practice paper, we present results from surveys of students in two CS courses offered in Spring 2020 at Virginia Tech, a large, public research university: a programming-intensive CS2-level course and an upper division theory course, Formal Languages and Automata. Spring 2020 was extraordinary as a result of the COVID-19 pandemic. Universities in the US and across the globe switched to a complete online delivery mode instead of the traditional face-to-face mode. This was challenging to both educators and students, as the transition took place on short notice in the middle of the Spring 2020 semester. We were interested to know those course components students perceived as most beneficial to their learning, before and then after the online transition, and their mode preferences for each regarding online vs. Face-to-Face. By comparing student reactions across courses, we gain insights on which components are easily adapted to online delivery, and which require further innovation. COVID was unfortunate, but gave a rare opportunity to compare students' reflections on F2F instruction with online instructional materials for half of a semester vs. entirely online delivery of the same course during the second half. Although the instruction provided during the second half of the semester may not be the same as what would have been provided had the course been designed as a fully online course from the beginning, it did provide the opportunity for us to acquire insights for future instruction. Results indicated that some course components were perceived to be more useful either before or after the transition, and preferences were not the same for the two courses. Furthermore, to determine what course components need further improvement before transitioning to fully online mode, we computed a logistic regression model. Results indicated that for each course, different course components both before and after the transition significantly affected students' preference of course modality. © American Society for Engineering Education, 2021