Miracle-dz/UniFAR-FTUs huggingface dataset:
H2O AutoML: Scalable Automatic Machine Learning

H2O is an open source, distributed machine learning platform designed to scale to very large datasets, with APIs in R, Python, Java and Scala. We present H2O AutoML, a highly scalable, fully-automated, supervised learning algorithm which automates the process of training a large selection of candidate models and stacked ensembles within a single function. The result of the AutoML run is a “leaderboard”: a ranked list of models, all of which can be easily exported for use in a production environment. Models in the leader-board can be ranked by numerous model performance metrics or other model attributes such as training time or average per-row prediction speed. The H2O AutoML algorithm relies on the eﬃcient training of H2O machine learning algorithms to produce a large number of models in a short amount of time. H2O AutoML uses a combination of fast random search and stacked ensembles to achieve results competitive with, and often better than, other frameworks which rely on more complex model tuning techniques such as Bayesian optimization or genetic algorithms. H2O AutoML trains a variety of algorithms (e.g. GBMs, Random Forests, Deep Neural Networks, GLMs), yielding a healthy amount of diversity across candidate models, which can be exploited by stacked ensembles to produce a powerful ﬁnal model. The eﬀectiveness of this technique is reﬂected in the OpenML AutoML Benchmark, which compares the performance of several of the most well known, open source AutoML systems across a number of datasets.
The 5 th Wave Challenges and Opportunities for Mobile-learning in Thailand

Society is changing dramatically in Thailand through technology and social developments driven by a technological and cultural revolution creating a greater digital divide that is based on technological capability; behavioural constraints in terms of learning needs; and engagement through access. This paper challenges the present notions of m-learning developments in Thai higher education and illustrates how The 5 th Wave may impact on how management of HE institutions will need to respond in order to move towards providing more appropriate learner-centred patterns of educational provision. Questions and issues are raised that directly relate to The 5 th Wave consciousness. These include operational, software and behavioural concerns. The paper concludes with a short discussion of the perceived overall outcome from addressing The 5 th Wave as it may require an overarching, progressivist m-Learning pedagogy designed to engage learners from disparate locations through the appropriate use of technology, software and media.
Cohort study : occurrence rate of occult gallbladder carcinoma and its curative strategies

Correspondence: Dr Irum Masood, Resident of Department of Surgery, Ziauddin University and Hospital, Karachi Cell: mail:drirum3@gmail.com Introduction: Carcinoma of the gallbladder is a disease with high mortality and is usually diagnosed as an incidental fi nding in the histopathology report aft er cholecystectomy for symptomatic gallstone disease1,11. Th e incidence of gallbladder malignancy is 1.2/100,000 people in the United States; the frequency of gallbladder malignancy is higher in Mexican and Native Americans, the higher incidence is found in the peoples of the Andes Mountains, in northeastern Europeans peoples, and in the Israelis. Th e gallbladder malignancy ratio is about 3:1 as in female-male respectively; incidence of the malignancy peaks in the seventh decade of their life1. Th e gallstone is the most common risk factor for gallbladder malignancy, present in 75-90% of gallbladder malignancies. Th e gallstones size plays an important role in the risk of developing malignancy. Diameter of the Abstract Background: Gallbladder specimen aft er cholecystectomy is one of the rarely come up against in routine histopathology. Accompanied by the great supposition, nearly all gallbladder specimens harbor the benign disease, but once in a while unexpected to fi nd malignancy. Occult gallbladder carcinoma is uncommon, highly lethal, although it is fi ft h prevailing malignancy in the gastrointestinal tract. Gallbladder malignancy is possible to cure if diagnosed at early stage and promptly treated surgically. Aim of study to fi gure out the occurrence of incidental carcinoma of the gallbladder and its curative options aft er elective cholecystectomy detected in routine histopathology. Methods: Cohort study was done in total 1522 specimens of gallbladder, that were submitt ed in the pathology department in Ziauddin University and Hospital, fi ve years of duration from Jan 2011 to Dec 2015, that were searched retrospectively for incidence of occult gallbladder carcinoma. Result: We found 16(1.05%) cases of occult gallbladder carcinoma out of 1,522 patients, 4(25%) well diff erentiated, 9(56.25%) moderately diff erentiated, 2(12.5%) poorly diff erentiated and 1(6.25 %) was undiff erentiated adenocarcinoma. Th e incidence rate of primary malignancy was 1.05% and commonly found in female with the complete number of laparoscopic cholecystectomies carried out in that time. During follow up two patients lost, rest of the patients no recurrence or metastasis seen at 6, 12 and 24 months but one patient still not completed two years follow up. Conclusion: Gallbladder malignancy may be curable if diagnosed in early stages. Laparoscopic cholecystectomy may not worsen the prognosis in such cases. Th erefore every gallbladder specimen should be examined histopathologically aft er cholecystectomy to detect possible occult gallbladder carcinoma.
More on the Taxation of Capital∗

Should capital income taxes be zero in the long run, as argued by Chamley (1986) and Judd (1985)? Or should instead capital be heavily taxed as suggested by Straub and Werning (2015)? We revisit the Ramsey literature on the optimal taxation of capital and make again the case for a low, possibly zero, tax on capital income.
Persian Gulf Snail Crude Venom (Conus textile): A Potential Source of Anti-Cancer Therapeutic Agents for Glioblastoma through Mitochondrial-Mediated Apoptosis.

BACKGROUND Research on animal toxins have shown toxicity potential on cancerous cell and tissues in the cultures. Conotoxins obtained from marine cone snails show the highest toxicity potential, so that several human deaths have been attributed to this species of snail. These toxins have proven to be valuable agents to inhibit enzymes, channels and proteins, in the nervous systems of humans. METHODS We have studied the effects of Conus textile crude venom on U87MG human glioma cells and their mitochondria as main inducers of apoptosis and human embryonic kidney 293 cells (HEK293) as non-cancerous normal control cells. Cellular toxicity assessments including MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and measurement of caspase-3 activation as well as mitochondrial toxicity assays including measurement of the activity of succinate dehydrogenase (SDH) enzyme, mitochondrial swelling, reactive oxygen species (ROS) production, collapse of mitochondrial membrane potential (MMP) and cytochrome c release were performed in U87MG human glioma cells and HEK293 cells (as non-cancerous normal cells). RESULTS The results illustrated the significant cytotoxic effect of Conus textile crude venom on U87MG human glioma cells, that inhibits 50% (IC50=10µg/mL) of the cell growth after 12 h of exposure. Viability measurement showed which the Conus textile crude venom is selectively cytotoxic to U87MG human glioma cells, and induced activation of caspase-3 and induction of cell apoptosis via through mitochondrial signaling. Conus textile crude venom also selectively increased mitochondria swelling, ROS formation, cytochrome c release and MMP decrease in cancerous mitochondria but not normal mitochondria. Conclusion; Based on the obtained results from this investigation, it is concluded that the Conus textile crude venom contains promising natural compounds to fight U87MG human glioma cells through activation of apoptosis intrinsic pathways.
Immune Functions in Males and Females: Does the Hormones Play The Role?

Review Article The open circuit system of immunity is composed of different cellular and non-cellular components. But the components are seemingly limited in view of their multi-faceted actions. Hence, the particularity and functional diversity of immune system lies in the mode of regulation of all of its components. There are different factors which regulate the proper function and modus operandi of several components of immune system. Among them one most important factor is regulation via hormones. There are different classes of hormones, but in context of immune system, hormones are immune-enhancing, immune-inhibitory or immune-neutral. In depth studies have shown that response of immune system varies with hormones of different kinds. It depends upon the context (in vivo and in vitro), nature of hormone (steroid, proteinaceous, peptide, amino acid and/ amino acid derivative), body condition (healthy vs. under pathological/clinical) and their behavior when in combination with other hormones and in contact with cellular and non-cellular components of immune system. It is notable that males and females of any animal differ physiologically and one of the reasons behind different physiology is involvement of hormones. Thus, it is a matter of investigation how gender wise differentiation exists at immunological level. Till date very little is known in this aspect and in depth molecular studies are on the way to explore out the reason. This review, however in brief encompasses the dimorphism of immunity and immune response in terms of gender under hormonal regulation.
THE MODERATING EFFECTS OF SUBSIDIARY SIZE AND AGE ON THE RELATIONSHIP BETWEEN INSTITUTIONAL DISTANCE AND ACCESS TO COMPLEMENTARY LOCAL ASSETS OF SUBSIDIARIES

The aim of this paper is to study the moderating role of subsidiary size and age on the relationship between institutional distance and the likelihood of subsidiary’s access to complementary local assets. Building upon institutional theory, we argue that the greater the institutional distance between home and host countries, the lesser the likelihood of subsidiary’s access to local complementary assets is. At the same time, we predict that the larger size of the subsidiary, and the older subsidiary, the more the likelihood of the subsidiary’s access to complementary local assets is. To test our proposed hypotheses, we use the survey data from the data set of the General Statistics Office of Vietnam at 264 subsidiaries located in Vietnam. We also complement our survey data with country-level data from different sources to test the proposed hypotheses. Our quantitative analysis confirms that the likelihood of larger and older subsidiaries’ access to complementary local assets in a more institutionally distant country are higher than smaller and young subsidiaries. The study provides implications for the international business literature and subsidiary management.
Post-Stack Multi-Azimuth Stratigraphic Inversion Applied to Unconventional Reservoir Characterization: A Case Study in the Fort Worth Basin; #41120 (2013)

*Adapted from article published in AAPG European Region Newsletter, September, 2012 (http://europe.aapg.org/wp-content/uploads/2011/12/AAPG_Newsletter__3er_trimestre_2012.pdf). Appreciation is expressed to AAPG European Region Council, Vlastimila Dvořáková,, President, their Editorial Board, Karen Wagner, Chief Editor, James Bailey and David Contreras, Coordinators, William Sassi, Coordinator of R&D Projects, and Jeremy Richardson, Office Director, AAPG European Region.
Predicting Intentions to take Medication in Patients with Pulmonary Tuberculosis: Impact of Attitudes, Subjective Norms and Perceived Behavioral Control

DOI: 10.21276/sjm.2018. 3.8. 1 Abstract: The present study aimed to investigate role of Attitudes towards medication, subjective norms and Perceived Behavioral Control in predicting Intentions of patients to take Anti-TB medication. The sample comprised of 147 patients with pulmonary TB, recruited from Gulab Devi Chest Hospital, Lahore. Correlation Research design was used. Urdu translated version of Theory of planned behavior questionnaire was used for assessment. Results showed that, Distance to hospital and Attitude of doctors and staff negatively predicted Intentions. However, Monthly family Income, Attitudes towards medication and Subjective Norms positively predicted Intentions. Results also revealed that high and low intenders were significantly different in terms of Behavioral, Normative and Control Beliefs. Findings of the present study highlighted the importance of environmental and patient related factors influencing the decisions to take medication. These factors should be considered while developing interventions to promote future medication adherence behavior as intentions drives behavior and patients has to be motivated in order to perform the behavior.
Carcass and meat parameters in Cornigliese sheep breed as affected by sex and age-class

Abstract A total of 72 animals from Cornigliese sheep breed were reared under homogeneous conditions, with the aim to assess the effect of sex (males, females) and age-class (heavy lambs, adults) on carcass and meat parameters. A model with fixed effects of herd, sex, slaughtering session, age-class and interaction (sex*age-class) was used; for slaughter data, the carcass weight was used as a covariate. The age-class effect was significant for most of the carcass measurements, indicating a late development in animals. Also, slaughter performance was significantly affected by age-class, with higher values (p<0.05) of hot carcass yield shown by heavy lambs than by adults. Carcass compactness index was lower in heavy lambs than in adults (p<0.001), and the lowest value (0.283; p<0.05) appeared in female heavy lambs. The percentage of fat trimmings in carcass and the tissue composition of sample cut were influenced by a significant interaction between age-class and sex (p<0.05): in males the age-class never affected the tissue composition of sample cut, as in females the muscle and fat percentages increased with age while the bone percentage decreased. The fat content of loin meat increased with age in females (p < 0.05) and decreased in males (p < 0.05). The poly-unsaturated fatty acids (FA) content of loin meat was higher in males than in females (p < 0.001), with saturated FA and mono-unsaturated FA revealing significant interactions between age-class and sex (p < 0.05). In conclusion, future implementation of genetic selection, oriented towards the improvement of meat production characteristics that are potentially present in the breed, is important.
The Dry Storage of Citrus Seeds

The survival of seeds of lemon (Citrus limon L.), lime [C. arantifolia (Christm.) Swing. ] and sour orange (C. aurantium L.) was examined under a wide range of constant moisture contents and temperatures. Seed longevity was increased by decreasing the moisture content and temperature of the storage environment. Maximum viability was maintained in the combination of storage conditions including the lowest moisture content (5 per cent) and lowest temperature ( 20 °C) investigated. The practicality of dry storage of citrus seed for genetic conservation is discussed.
SPATIAL AND TEMPORAL PATTERNS OF ANNUAL PRECIPITATION VARIABILITY OVER THE IBERIAN PENINSULA

In this study we have examined the spatial and temporal variability of the annual precipitation observations over the Iberian Peninsula (IP) for 47 years and 51 stations. Empirical orthogonal functions (EOFs) were obtained in order to characterise the variability. Four regional precipitation regimes have been identified and the corresponding principal components (PCs) were subjected to spectral analysis in order to obtain the structure of the temporal variations. The relationship between the precipitation and circulation patterns is also investigated. The four leading PCs of annual precipitation are associated with the following patterns: East Atlantic (EA); North Atlantic Oscillation (NAO); Southern Oscillation Index (SOI); Scandinavia (SCAND). The spectra of the precipitation PCs show statistically significant oscillations coherent with those found in the time series of the teleconnection indices. A reconstruction of the time series as a function of the PCs is provided in order to obtain a characterisation of precipitation climatology over the IP. © 1998 Royal Meteorological Society.
Understanding Patients’ Beliefs about Hypertension in Primary Health Care in Bahrain: A Cross-Sectional Study

Hypertension is a major cause of morbidity and mortality worldwide. Patients’ beliefs and knowledge about hypertension have a strong influence on compliance to treatment and control of the disease. Up to date, there is no previous data on hypertension health beliefs in Bahrain. Therefore, this research was conducted to study patients’ beliefs and explore the association between patients’ characteristics and their beliefs. Aim: To understand Bahraini patients’ beliefs about hypertension in primary health care in Bahrain. Objectives: To explore patients’ beliefs about hypertension in primary health care in Bahrain; to study the association between personal characteristics (demographic, socioeconomic and medical) and patients’ beliefs. Study design: Cross-sectional study. Settings: Data was collected from two primary care health centers in each health region in Kingdom of Bahrain using validated questionnaire. Participants 454 hypertensive adult Bahraini patients ≥18 years, who were attending primary care within 10 days period in February 2018 (1 st – 14 th February), were recruited. Pregnant women, patients with psychotic disorder or cognitive impairment, and patients who are unable to communicate were excluded. Data was analyzed qualitatively for themes using SPSS version 23.0. Results: Patients’ mean age was 58.2 ± 11.697 years with females constituting 58.4%. Based on the Health Beliefs Model, participants have strong beliefs regarding their susceptibility to the effects of hypertension, seriousness of its complications and the benefits of a proper and healthy management plan. On the other hand, they have weak beliefs in the efficacy of the barriers (i.e. alternative medicine and medication side effects) toward hypertension management. The most variables having the largest influence on patients’ beliefs were duration of having hypertension and existence of other chronic medical problems. Conclusion: The findings suggest that participants were fairly knowledgeable about hypertension. We concluded that patients’ perceptions are an important factor in hypertension care and should be deeply explored.
Gene expression profile in mouse bacterial chronic rhinosinusitis

Persistent infection in the paranasal sinuses impairs sinus drainage and leads to bacterial chronic rhinosinusitis. Greater knowledge of the key molecules in the pathology will help to clarify the pathogenesis. Study of the gene expression profile and analysis of the associated pathway is important to identify key molecules. This study investigates the expression of different genes and analyzes the key pathway in the pathological process of bacterial chronic rhinosinusitis. Bacterial chronic rhinosinusitis was induced in mice using a Merocel nasal pack inoculated with Staphylococcus aureus. Three months of mucosa samples were collected for histological and ELISA analysis, and gene expression was tested using DNA microarray. Differentially expressed genes were selected and verified for pathway analysis. The nasal mucosa of mice with chronic rhinosinusitis showed epithelial damage and lamina propria edema in extra cellular matrix with obvious mucosal inflammation. A total of 6,018 genes in bacterial chronic rhinosinusitis group were differentially expressed compared with the control. Among them, plasma, coagulation factors, urokinase plasminogen activator and urokinase receptor plasminogen activator expression were increased. Following gene ontology analysis and reverse transcription-quantitative polymerase chain reaction, coagulation cascades associated cytokines were found to be upregulated in bacterial chronic rhinosinusitis. The present results suggest that, bacterial chronic rhinosinusitis showed severe mucosal inflammation and genes differential expression in the pathogenesis. In this process, the coagulation cascades pathways were upregulated.
A Study of Minimally Invasive Plate Osteosynthesis with Locking Compression Plates for the Treatment of Proximal Humerus Fractures

DOI: 10.21276/sjm.2018. 3.6. 5 Abstract: The principle of the minimally invasive technique is to implant specific bony plate which is fixed across fractures via small incisions of the skin, muscle, and periosteum. The aim of the study was to find the functional outcomes in patients treated with proximal humerus fractures with a minimally invasive technique using locking compression plates. Methods: The cross-sectional study was conducted in the Department of Orthopedics, Prathima Institute of Medical Sciences, Nagunur, Karimnagar. A total of 39 patients were included in the study. The patients were selected using the inclusion criteria and they underwent operations under general anesthesia followed by early mobilization and follow up at the intervals of 3 months, 6 months and 12 months to evaluate functional outcomes according to Constant-Murley criteria. Results: The fractures were classified according to the NEER/AO/ASIF classification of fractures of the humerus. The type A fractures were found in 20 out of 39 patients 51.28% A1 fractures were in 8 patients A2 in 5 patients and A3 in 7 patients and 19 fractures were type B 48.72% and B1 and B3 had in 7 patients each and B2 had 5 patients. The mean Constant-Murley score was 89.25 points at the end of one year follow up in 2 part fractures. According to Constant-Murley score, 85% had an excellent outcome, 10% had a good functional outcome and 5% had moderate outcomes. All the fractures were united on an average time of 19 weeks (14-24). In the Three-part fractures, the average Constant-Murley score at the end of one year was 81 points. The Constant-Murley score showed 78.94% had excellent outcomes, 15% had a good functional outcome and 5.26% had a moderate outcome. Conclusion: Within the limitation of the present study it can be concluded that minimal invasive plate osteosynthesis with locking compression plate is a good technique for the treatment of proximal humerus fractures. It provides good stability, functional outcomes and minimal post-operative complications.
Immigrant Inventors and Diversity in the Age of Mass Migration

A possible unintended but damaging consequence of anti-immigrant rhetoric, and the policies it inspires, is that they may put high-skilled immigrants off more than low-skilled ones at times when countries and businesses intensify their competition for global talent. We investigate this argument following the location choices of thousands of immigrant inventors across US counties during the Age of Mass Migration. To do so we combine a unique USPTO historical patent dataset with Census data and exploit exogenous variation in both immigration flows and diversity induced by former settlements, WWI and the 1920s Immigration Acts. We find that co-ethnic networks play an important role in attracting immigrant inventors. However, we also find that immigrant diversity acts as an additional significant pull factor. This is mainly due to externalities that foster immigrant inventorsâ€™ innovativeness. These findings are relevant for todayâ€™s advanced economies that have become major receivers of migrant flows and, in a long-term perspective, have started thinking about immigration in terms of not only level but also composition.