Miracle-dz/UniFAR-FTUs huggingface dataset:
Observing the Diversity of Alleviating Manoeuvres in Cervical Dystonia

The alleviating manoeuvres (AMs), classically referred to as “sensory tricks” are voluntary manoeuvres that temporarily improve dystonic postures. Although self-induced application of sensory stimuli is the most common AM, clinical experience suggests that the phenomenon is more diverse, possibly reflecting the complexity of the pathophysiological mechanisms provoking dystonia. We specifically explored five different categories of AMs in patients with cervical dystonia (CD): 1) pure sensory; sensorimotor manoeuvres in which sensory input is associated with a motor output component incorporating 2) active non-oppositional, 3) active oppositional or 4) passive motion; and 5) complex motor manoeuvres. Using an ad hoc structured clinical interview, we collected data on the frequency and efficacy of each subgroup and the possible correlation with some clinical features of CD. One-hundred patients were included in this study. Seventy-five percent of patients reported at least one AM. Half of those reporting AMs acknowledged the use of different phenomenological categories of AMs. Different categories of AMs showed noteworthy differences in prevalence of use amongst CD patients, and in the relationship of frequency of use and efficacy to patient demographic and clinical characteristics. Our observational study supports the existence of different AMs that are phenomenologically different and could be related to different degrees of sensorimotor integration dysfunction. Given that AMs are probably the most efficacious, non-invasive strategy to ameliorate CD and other dystonias, accurate phenotyping and physiological exploration of their diversity may produce relevant insight for new therapeutic strategies or appraisal of existing ones.
Silage Fermentation Quality, Anthocyanin Stability, and in vitro Rumen Fermentation Characteristic of Ferrous Sulfate Heptahydrate-Treated Black Cane (Saccharum sinensis R.)

Pretreatment of lignocellulose agricultural biomass with iron prior to ensiling is required to accelerate biomass breakdown during fermentation, which could result in functional microorganisms and chemicals that reduce nutrition loss, harmful substances, and improve animal performance. The objective of this study was to investigate the effects of increasing dilutions of ferrous sulfate heptahydrate (FS) pretreatment at fresh matter concentrations of 0, 0.015, and 0.030% on the fermentation quality of black cane (BC) silage, anthocyanin stability, ruminal biogas, rumen fermentation profile, and microbial community. Pre-ensiled and silage materials were evaluated. High moisture, fiber, anthocyanin, and lignification of biomass, as well as undesirable ensiling microorganisms, were found in BC' pre-ensiled form. Increasing dilutions of FS incorporated into silages were observed to linearly decrease dry matter, anthocyanin, and nutritive value losses. The lignin values decreased linearly as the percentage of FS increased up to 0.030%. Given that the ruminants were fed pre-ensiled materials, BC silage treated with 0.030% FS dilution had comparable results to pre-ensiled BC in terms of increasing in vitro volatile fatty acid concentrations, maintaining total gas production, and reducing methane production, when compared to other FS-treated silages. In addition, BC silage treated with a 0.030% FS dilution inhibited methanogenic bacteria and regulated cellulolytic bacteria in rumen fluid. Overall, the anthocyanin content of BC remained constant throughout the rumen fermentation process after increasing dilutions of FS, indicating that BC is a viable ruminant feedstock and that pretreatment of BC with dilute FS-assisted ensiling at 0.030% could be used to generate ruminant diets.
Visual Strategies for Eye and Head Movements During Table Tennis Rallies

The purpose of this study was to clarify the properties of visual strategies for gaze, eye, and head movements in skilled table tennis players during rallies. Collegiate expert and semi-expert table tennis players conducted forehand rallies at a constant tempo using a metronome. Two tempo conditions were used in the order of 130 and 150 bpm. Participants conducted a 20-stroke rally under each tempo condition. Horizontal and vertical angles between the gaze point and ball positions at the time the ball bounced (gaze-ball angle) were analyzed with the image that was recorded by an eye tracking device equipped with Gyro sensor. Eye and head movements during rallies were also recorded with the eye tracking device and Gyro sensor, respectively. The results showed that the gaze-ball angle of expert players was significantly larger than that of semi-expert players. This result indicates that expert players tended to keep their gaze position on the ball shorter than semi-expert players. We also found that eye movements of expert players were significantly smaller than that of semi-expert players. Furthermore, as the result of multiple regression analysis, the effect of eye movements on the gaze-ball angle was significantly higher than that of head movements. This result indicates that the gaze-ball angle during table tennis rallies could be associated with eye movements rather than head movements. Our findings suggest that the visual strategies used during table tennis rallies are different between expert and semi-expert players, even though they both have more than 10 years of experience.
Factors Influencing the Outcome of Symptomatic Intracranial Artery Stenosis With Hemodynamic Impairment After Short and Long-Term Stent Placement

Objective Stent placement is a feasible approach worldwidely for patients with symptomatic intracranial artery stenosis (sICAS) and hemodynamic impairment (HI) who are at high risk of recurrent stroke after medical treatment. Exploration of factors associated with poor outcomes after stent placement could help develop better individualized therapeutic strategies. Methods This study conducted a post-hoc analysis of a prospective, multicenter registry study of stent use for sICAS with HI in China. Patient and clinical demographics, and stenotic lesion images were analyzed using univariate and multivariate Cox regression to the time until any endpoints or the end of the follow-up period. The short-term endpoint included any transient ischemic attack (TIA), stroke, or death within 1 month after stent placement. The long-term endpoints included the short-term endpoints and any TIA or stroke in the region of the affected artery that occurred more than 1 month after stent placement. Results Two hundred and ninety two patients were included, with 13 short-term and 39 long-term endpoints. Multivariate Cox regression analysis revealed that lesions at the arterial origin or bifurcation (Hazard Ratio (HR) = 7.52; 95% CI, 1.89–29.82; p = 0.004) were significantly associated with higher short-term risk. Baseline renal insufficiency reduced the risk (HR = 0.08; 95% CI: 0.01–0.68; p = 0.021). Factors significantly associated with higher long-term risk included irregular or ulcerated plaques at the lesion (HR = 2.15; 95% CI: 1.07–4.33; p = 0.031). Subgroup analyses indicated that higher risk occurred in the older age group (age>59 years, HR = 3.73, 95% CI: 1.27–10.97, p = 0.017), and not in the younger group (age≤59 years, HR = 1.12, 95% CI: 0.42–3.03, p = 0.822). Conclusion Irregular or ulcerated plaques in older patients and lesions at the arterial opening or bifurcation were more likely to result in adverse endpoints for stent placement during long or short -term follow-up. Investigation of these factors might facilitate the development of individualized therapeutic strategies for this population. Clinical Trial Registration http://www.clinicaltrials. gov, identifier: NCT01968122.
Impact of Electrical Connection Distance on the Open Loop Modal Resonance of Grid Connected Photovoltaic Farms

The grid connection of photovoltaic (PV) farms may cause power system oscillations under the condition of open-loop modal resonance (OLMR). This study elucidated the origin of the induced low-frequency oscillations and examined the impact of the electrical distance between grid-connected PV farms on OLMR intensity by using a simplified real power network. A linearized state-space model of the real power system comprising grid-connected PV farms was derived. Based on this, an OLMR analysis was performed to examine the impact of the electrical distance between the grid-connected PV farms as well as between each grid-connected PV farm and the main grid. The OLMR analysis results indicate that the strength of the OLMR increases with the electrical distance between the PV farms, thereby leading to growing power oscillations. Moreover, the increase of electrical distance between each of the grid-connected PV farms and the main grid has a greater effect on OLMR intensity. Additionally, the non-linear simulations were performed to confirm the correctness of the OLMR analysis. Finally, by re-tuning the parameters of the control system of the grid-connected PV farms to reduce the phase-locked loop bandwidth, the OLMR can be effectively eliminated to avoid power oscillations.
Potential of Biochar to Reduce Greenhouse Gas Emissions and Increase Nitrogen Use Efficiency in Boreal Arable Soils in the Long-Term

Biochars have potential to provide agricultural and environmental benefits such as increasing soil carbon sequestration, crop yield, and soil fertility while reducing greenhouse gas (GHG) emissions and nitrogen leaching. However, whether these effects will sustain for the long-term is still unknown. Moreover, these effects were observed mostly in highly weathered (sub-) tropical soils with low pH and soil organic carbon (SOC). The soils in northern colder boreal regions have typically higher SOC and undergo continuous freeze-thaw cycles. Therefore, effects of biochars in these regions may be different from those observed in other climates. However, only a few biochar studies have been conducted in boreal regions. We aimed to assess the long-term effects of biochars on GHG emissions, yield-normalized non-CO2 GHG emissions (GHGI), and N dynamics in boreal soils. For this, we collected data from four existing Finnish biochar field experiments during 2018 growing season. The experiments were Jokioinen (Stagnosol), Qvidja (Cambisol), Viikki-1 (Stagnosol), and Viikki-2 (Umbrisol), where biochars were applied, 2, 2, 8, and 7 years before, respectively. The GHG emissions, crop yield, soil mineral N, and microbial biomass were measured from all fields, whereas, additional measurements of plant N contents and N leaching were conducted in Qvidja. Biochars increased CO2 efflux in Qvidja and Viikki-2, whereas, there were no statistically significant effects of biochars on the fluxes of N2O or CH4, but in Qvidja, biochars tended to reduce N2O fluxes at the peak emission points. The tendency of biochars to reduce N2O emissions seemed higher in soils with higher silt content and lower initial soil carbon. We demonstrated the long-term effects of biochar on increased crop yield by 65% and reduced GHGI by 43% in Viikki-2. In Qvidja, the significant increment of plant biomass, plant N uptake, nitrogen use efficiency, and crop yield, and reduction of NO3 −–N leaching by the spruce biochar is attributed to its ability to retain NO3 −–N, which could be linked to its significantly higher specific surface area. The ability of the spruce biochar to retain soil NO3 −–N and hence to reduce N losses, has implications for sustainable management of N fertilization.
Mechanisms Responsible for Sand Hazards Along Desert Highways and Their Control: A Case Study of the Wuhai–Maqin Highway in the Tengger Desert, Northwest China

Highways in deserts usually suffer from severe sand hazards under the effect of wind-blown sand. In this article, the author has revealed the disaster-causing mechanisms of the Wuhai–Maqin Highway in the Tengger Desert, Northwest China. A sand control system with six belts was proposed and established for the highway, and its sheltering effect was examined through on-site monitoring. The results showed that from 2018 to 2019, the sand drift potential was dominated by northwest, northeast, and south winds, which indicated a low-energy windy environment, with a resulting southeast direction of sand transport. The particle size of surface sediments was mainly distributed between 1. 26Φ and 2. 5Φ, indicating fine sand and medium sand. The sand flux was mainly concentrated below 30 cm, accounting for 89.46% of the total sand transport. Airflow around the control system was significantly attenuated, with a maximum wind speed decreasing rate of 95.88%. The windproof efficiency of the control system against the near-surface wind-blown sand was more than 90%. This study provides a significant reference for the control of highway sand hazards in other deserts.
A Mouse-Adapted Model of HCoV-OC43 and Its Usage to the Evaluation of Antiviral Drugs

The human coronavirus OC43 (HCoV-OC43) is one of the most common causes of common cold but can lead to fatal pneumonia in children and elderly. However, the available animal models of HCoV-OC43 did not show respiratory symptoms that are insufficient to assist in screening antiviral agents for respiratory diseases. In this study, we adapted the HCoV-OC43 VR-1558 strain by serial passage in suckling C57BL/6 mice and the resulting mouse-adapted virus at passage 9 (P9) contained 8 coding mutations in polyprotein 1ab, spike (S) protein, and nucleocapsid (N) protein. Pups infected with the P9 virus significantly lost body weight and died within 5 dpi. In cerebral and pulmonary tissues, the P9 virus replication induced the production of G-CSF, IFN-γ, IL-6, CXCL1, MCP-1, MIP-1α, RANTES, IP-10, MIP-1β, and TNF-α, as well as pathological alterations including reduction of neuronal cells and typical symptoms of viral pneumonia. We found that the treatment of arbidol hydrochloride (ARB) or Qingwenjiere Mixture (QJM) efficiently improved the symptoms and decreased n gene expression, inflammatory response, and pathological changes. Furthermore, treating with QJM or ARB raised the P9-infected mice’s survival rate within a 15 day observation period. These findings suggested that the new mouse-adapted HCoV-OC43 model is applicable and reproducible for antiviral studies of HCoV-OC43.
Change in Latent Gray-Matter Structural Integrity Is Associated With Change in Cardiovascular Fitness in Older Adults Who Engage in At-Home Aerobic Exercise

In aging humans, aerobic exercise interventions have been found to be associated with more positive or less negative changes in frontal and temporal brain areas, such as the anterior cingulate cortex (ACC) and hippocampus, relative to no-exercise control conditions. However, individual measures such as gray-matter (GM) probability may afford less reliable and valid conclusions about maintenance or losses in structural brain integrity than a latent construct based on multiple indicators. Here, we established a latent factor of GM structural integrity based on GM probability assessed by voxel-based morphometry, magnetization transfer saturation, and mean diffusivity. Based on this latent factor, we investigated changes in structural brain integrity during a six-month exercise intervention in brain regions previously reported in studies using volumetric approaches. Seventy-five healthy, previously sedentary older adults aged 63–76 years completed an at-home intervention study in either an exercise group (EG; n = 40) or in an active control group (ACG; n = 35). Measures of peak oxygen uptake (VO2peak) taken before and after the intervention revealed a time-by-group interaction, with positive average change in the EG and no reliable mean change in the ACG. Significant group differences in structural brain integrity changes were observed in the right and left ACC, right posterior cingulate cortex (PCC), and left juxtapositional lobule cortex (JLC). In all instances, average changes in the EG did not differ reliably from zero, whereas average changes in the ACG were negative, pointing to maintenance of structural brain integrity in the EG, and to losses in the ACG. Significant individual differences in change were observed for right ACC and left JLC. Following up on these differences, we found that exercising participants with greater fitness gains also showed more positive changes in structural integrity. We discuss the benefits and limitations of a latent-factor approach to changes in structural brain integrity, and conclude that aerobic fitness interventions are likely to contribute to brain maintenance in old age.
Improving University Students' Mental Health During the COVID-19 Pandemic: Evidence From an Online Counseling Intervention in Italy

Background The mental health of university students is significantly affected when faced with public health emergencies and requires specific interventions to help support and prevent any long-lasting effects that the pandemic may have on their mental health status. This study aims to evaluate the impact of an online individual counseling intervention provided by the University of Foggia and carried out during the COVID-19 pandemic on the mental health status of a sample of university students. Methods 32 Italian undergraduate students took part in a one-group pretest-posttest research design. The data was gathered in two times: before the start of the counseling intervention (T1), positive and negative affect, satisfaction with life, global mental distress, anxiety, stress, and future time perspective were collected, at the end of the counseling intervention (T2), the same dimensions were measured. A one-way repeated measures multivariate analysis of variance (MANOVA) was performed, and single Bonferroni-corrected dependent t-tests were conducted on variables showing a significant change over time. Results The results showed that positive affect, subjective well-being, and future time perspective increased significantly after the intervention. In contrast, the participants reported significantly lower levels of negative affect, global mental distress, state and trait anxiety, as well as perceived stress over time. Conclusions The study demonstrates the promising impact of online counseling intervention and its efficient contribution in promoting the well-being of university students. The results contribute to the ongoing debate concerning the psychological impact of the COVID-19 pandemic on young adults, helping professionals develop more efficient clinical and psychological interventions.
Regulatory Effect of Sea-Buckthorn Procyanidins on Oxidative Injury HUVECs

As society develops and aging populations increase, the incidence of arteriosclerosis, a seriously harmful cardiovascular disease (CVD) which mostly results from endothelial cellular oxidative damage, has continuously risen. Procyanidins from sea-buckthorn is a powerful antioxidant, although its protective effect on the cardiovascular system is not yet clearly understand. In this study, oxidative damaged HUVECs induced by palmitate acid (PA) were used as a model and the regulatory effect of procyanidins from sea-buckthorn (SBP) on HUVECs were investigated. The results showed SBP can be used for 12 h by HUVECs and had no detective cytotoxicity to them under 400 μg/L. Also, different concentrations of SBP can increase mitochondrial membrane potential and NO level and decrease LDH leakage in a dose-effect relationship, indicating SBP can improve oxidative damage. In addition, western blots and qPCR results showed SBP regulation on oxidative injured HUVECs is probably through p38MAPK/NF-κB signal pathway. This study revealed the molecular mechanism of procyanidins in decreasing endothelial oxidative damage, providing a theoretical foundation for further research on natural bioactive compounds to exert antioxidant activity in the body and prevent and improve cardiovascular diseases.
Integrated Features for Optimizing Machine Learning Classifiers of Pediatric and Young Adults With a Post-Traumatic Headache From Healthy Controls

Post-traumatic headache (PTH) is a challenging clinical condition to identify and treat as it integrates multiple subjectively defined symptoms with underlying physiological processes. The precise mechanisms underlying PTH are unclear, and it remains to be understood how to integrate the patient experience with underlying biology when attempting to classify persons with PTH, particularly in the pediatric setting where patient self-report may be highly variable. The objective of this investigation was to evaluate the use of different machine learning (ML) classifiers to differentiate pediatric and young adult subjects with PTH from healthy controls using behavioral data from self-report questionnaires that reflect concussion symptoms, mental health, pain experience of the participants, and structural brain imaging from cortical and sub-cortical locations. Behavioral data, alongside brain imaging, survived data reduction methods and both contributed toward final models. Behavioral data that contributed towards the final model included both the child and parent perspective of the pain-experience. Brain imaging features produced two unique clusters that reflect regions that were previously found in mild traumatic brain injury (mTBI) and PTH. Affinity-based propagation analysis demonstrated that behavioral data remained independent relative to neuroimaging data that suggest there is a role for both behavioral and brain imaging data when attempting to classify children with PTH.
Altered Vaginal Microbiota Composition Correlates With Human Papillomavirus and Mucosal Immune Responses in Women With Symptomatic Cervical Ectopy

Cervical ectopy is a benign condition of the lower genital tract that is frequently detected in women of reproductive age. Although cervical ectopy is regarded as a physiological condition, some women experience symptoms such as leucorrhoea, persistent bleeding and recurrent vaginal infections that require medical intervention. Cervical ectopy has not been linked to cervical cancer, but it is thought to facilitate the acquisition of sexually transmitted diseases (STDs), like Human Papillomavirus (HPV) infection, as it provides a favorable microenvironment for virus infection and dissemination. We and others have described the presence of oncogenic HPV types in women with symptomatic cervical ectopy. The relevance of this finding and the impact of symptomatic cervical ectopy on the cervicovaginal microenvironment (vaginal microbiota, immune and inflammatory responses) are currently unknown. To shed some light into the interplay between HPV, the vaginal microbiota and mucosal immune and inflammatory responses in the context of this condition, we enrolled 156 women with symptomatic cervical ectopy and determined the presence of HPV using a type-specific multiplex genotyping assay. Overall, HPV was detected in 54.48% women, oncogenic HPV types were found in more than 90% of HPV-positive cases. The most prevalent HPV types were HPV16 (29.4%), HPV31 (21.17%) and HPV18 (15.29%). Next, we evaluated the vaginal microbial composition and diversity by 16S rDNA sequencing, and quantified levels of cytokines and chemokines by flow cytometry using bead-based multiplex assays in a sub-cohort of 63 women. IL-21 and CXCL9 were significantly upregulated in HPV-positive women (p=0.0002 and p=0.013, respectively). Women with symptomatic cervical ectopy and HPV infection had increased diversity (p<0.001), and their vaginal microbiota was enriched in bacterial vaginosis-associated anaerobes (Sneathia, Shuttleworthia, Prevotella, and Atopobium) and depleted in Lactobacillus spp. Furthermore, the vaginal microbiota of women with symptomatic cervical ectopy and HPV infection correlated with vaginal inflammation (IL-1β, rho=0.56, p=0.0004) and increased mucosal homeostatic response (IL-22, rho=0.60, p=0.0001). Taken together, our results suggest that HPV infection and dysbiotic vaginal communities could favor a vaginal microenvironment that might delay the recovery of the cervical epithelium in women with symptomatic cervical ectopy and favor STDs acquisition.