Miracle-dz/UniFAR-FTUs huggingface dataset:
EXPLORING THE INNOVATIVE IDEAS IN SERVICE INDUSTRY

: This research is essential, considering there are very few differences in services between law offices in the legal services industry. In addition, the emergence of opportunities for new communities in digital form, both in the business and social worlds, requires new rules, which may become opportunities for legal practitioners. This study aims to get service innovation ideas for micro, small, and medium-scale companies (MSMEs) in the service industry, specifically for law office service companies. For this purpose, data was collected using a focus group discussion (FGD) approach attended by 30 legal practitioners as informants to find service innovation ideas in legal service-based companies. The sample was selected using a purposive sampling method with the criteria of having worked at a legal services company for at least three years, considering the need for innovation in running a business. This criterion was confirmed through initial interviews with informants. Data is analysed using content analysis. The results of this study indicate that the proposed innovation idea is closely related to the use of technology, such as the use of online platforms to promote and even conduct legal consultations, document processing automation technology, an application that functions as a reminder of the schedule, either the schedule for hearing in court or the schedule for uploading the required documents. In addition, collaboration is also needed to generate innovative ideas, both for the development of digital platforms or eco-systems as well as collaboration with other stakeholders such as prospective clients and employees to formulate service improvements and management of law office services.
Black-5, Congo Red and Methyl Orange : Chemical Degradation of Azo-Dyes by Agrobacterium

: The commercial processing of various biomaterials extensively uses azo dyes (including reactive, direct, acidic, and basic dyes). These industrial applications produce wastewater containing a large volume of solubilized azo dye and hydrolyzed by-products. The treatment of such wastewater is primarily carried out by chemical and, to an extent, physical methods, which lack selectivity and efﬁciency. Notably, the chemical methods employ free radicals and oxidizing agents that further increase the chemical waste and produce non-biodegradable side-products. Therefore, there is an increasing trend of using microbial-assisted methods. The current study identiﬁed a speciﬁc Agrobacterium strain (JAS1) that degraded the three structurally distinct azo dyes (Reactive Black 5, Methyl Orange, Congo Red). JAS1 can tolerate high concentrations and be used to perform the in-solution degradation of azo dyes, respectively: Methyl Orange (5.5 g/L and 5.0 g/L), Congo Red (0.50 g/L and 0.40 g/L), and Reactive Black 5 (0.45 g/L and 0.40 g/L). Our study elucidated the molecular mechanisms (primarily enzymatic degradation and adsorption) responsible for the JAS-1-assisted decoloration of azo dyes. The JAS-1-assisted degraded products from these azo dyes were found biodegradable as the germination and seedling growth of wheat seeds were observed. To enhance the scope of the study, JAS1-assisted decolorization was studied for cellulosic materials, indicating a potential application in de-inking and de-dyeing process in recycling industries.
Experimental sandstone weathering using different wetting and drying moisture amplitudes

Wetting and drying is an acknowledged yet still poorly understood rock weathering process. Previous experiments documented in the literature measure physical changes or mass loss in relation to moisture oscillations but only one study directly compares different moisture amplitudes by using different modes of moisture application. In this experimental study, four sets of sandstone tablets are subjected to 48 h wetting and drying cycles at set moisture content fluctuations of 29, 42, 56 and 63% respectively. A common moisture application, full immersion, is used for all four sets. Mass loss after 52 cycles averaged 0·27%, some three times more than that of the control samples. Average porosity of the samples increased, while water absorption capacities and the saturation coefficients of the samples decreased. No discernable difference in mass loss or change in physical properties was found between the different sample sets. When compared with previous studies, results suggest that the effect of moisture application type may be more of a controlling factor on the weathering effect than actual moisture content achieved. A need to move towards a more standardized approach in wetting and drying experimental studies is emphasized. Copyright © 2007 John Wiley & Sons, Ltd.
their own

Two compounds known to covalently bind to DNA after their activation with cytochromes P450 (CYPs), carcinogenic benzo(a)pyrene (BaP) and an antineoplastic agent ellipticine, were investigated for their potential to induce CYP and NADPH:CYP reductase (POR) enzymes in rodent livers, the main target organ for DNA adduct formation. Two animal models were used in the study: (i) rats as animals mimicking the fate of ellipticine in humans and (ii) mice, especially wild-type (WT) and hepatic POR-null (HRN™) mouse lines. Ellipticine and BaP induce expression of CYP1A enzymes in livers of experimental models, which leads to increase in their enzymatic activity. In addition, both compounds are capable of generating DNA adducts, predominantly in livers of studied organisms.
Effect of Active and Passive Stretching on Symptoms in Stable COPD: A Systematic Review and Meta-Analysis

Background: Chronic obstructive pulmonary disease (COPD) is a chronic lung disease with high mortality and disability rate. It caused the progressive air�ow obstruction along with the change of relevant soft tissue. Stretching could lengthen the shorten respiratory muscle and increase its �exibility. Objectives: To investigate the effectiveness of stretching on the COPD patients. Methods: The PRISMA guideline was used to perform the review. We searched on six online databases (Web of Science, PubMed, Embase, Cochrane Library, CNKI and Wanfang Database) from inception until March 2022. The quality of the studies was appraised by PEDro scale. The pooled effect sizes of exercise capability, lung function parameters, dyspnea, psychological status and quality of life were reported. Result: Of 422 studies, 11 studies (424 participants) met the inclusion criteria. The overall effect size of the 6MWT showed statistical difference between stretching group and the control group (P<0.00001). Among the lung function parameters, only respiratory rate (RR) and expiratory time (Te) showed superior statistical effect. The data about the psychological state, dyspnea and quality of life were too scant to conclude. Conclusion: Stretching seemed to have strong effectiveness on improving the exercise capacity, and the breathing temporal parameters could be changed through stretching.
LINC01436 Promotes the Progression of Gastric Cancer via Regulating miR-513a-5p/APE1 Axis

Background: Gastric cancer (GC) is one of the deadliest cancer worldwide. Multiple long non-coding RNAs (lncRNAs) are recently identified as crucial oncogenic factors or tumor suppressors in GC. In this study, we aimed to probe into the effect of LINC01436 on GC progression. Methods: LINC01436 and miR-513a-5p expressions in GC tissue samples were measured using quantitative real-time polymerase chain reaction (qRT-PCR). Western blot was used to detect the expression of apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) expression. Human GC cell lines AGS and BGC-823 were employed to investigate the function and mechanism of LINC01436 in GC. Cell counting kit-8 (CCK-8) assay was used to assess the effect of LINC01436 on proliferation. Flow cytometry was utilized to explore the effect of LINC01436 on apoptosis, and Transwell assay was conducted to detect the effect of LINC01436 on the migration and invasion. Colony formation assay was performed to evaluate the effect of LINC01436 on radioresistance of GC cells. Furthermore, luciferase reporter assay and RNA immunoprecipitation assay were conducted to confirm the binding relationship between miR-513a-5p and LINC01436. Additionally, Western blot was used to study the regulatory function of LINC01436 and miR-513a-5p on APE1. Results: LINC01436 expression of GC clinical samples was remarkably increased and LINC01436 was correlated with unfavorable pathological indexes. LINC01436 high expression was associated with shorter overall survival time. Its overexpression observably promoted the proliferation, metastasis and radioresistance of GC cells, and its knockdown suppressed the malignant phenotypes of GC cells. LINC01436 overexpression markedly reduced the miR-513a-5p expression via sponging it and enhanced the APE1 expression. MiR-513a-5p overexpression or APE1 knockdown reversed the effects of LINC01436 on GC cells. Conclusion: LINC01436 is a molecular sponge of tumor suppressor miR-513a-5p, which indirectly enhances the APE1 expression and functions as the oncogenic lncRNA in GC.
Social Capital and Homeownership among Immigrants: Insights for Brunei

- The increasing number of immigrants in the host country has often raised demands for several services. This may refer to basic needs such as education, employment and housing. The study's main problem is the inaccessibility of the middle-income immigrants’ generations in Brunei Darussalam to homeownership. Although the immigrants’ generations have been staying long in the country and born locally, they are inaccessible to housing and homeownership. This study aims to answer the research question that guides this paper “what are the social capital factors affecting the immigrants’ homeownership? Therefore the objective of this study is to investigate the relationship between social capital factors and the homeownership status of the immigrants. The study discussed social capital factors, including culture, social network, trust and loyalty on homeownership of the immigrants in Brunei Darussalam. The data of this study were collected from a questionnaire and analysed using SPSS and SEM. The analysis on the relationship between social capital factors and homeownership shows p = . 0136*, which implies that social capital directly impacts immigrants’ homeownership in Brunei. However, homeownership access in practice is determined by housing policy and that the immigrants are naturalised citizens. The result of the study has led to other associated factors like housing policy included for future research.
INDONESIAN BANKING STRATEGY IN IMPROVING CREDIT DISTRIBUTION

: This research is performed in order to test the influence of the variable Third-party Funds, Capital Adequacy Ratio (CAR), Non Performing Loan (NPL), Loan to Deposit Ratio (LDR), and Operational Efficiency Ratio toward Credit Distribution at Banking in Indonesia. The data used in this research was obtained from the annual financial report data period 2015-2019. The sample used in this research is 10 General Bank of 43 General Bank at Indonesian Stock Exchange. The results show that the Third-party Funds, CAR, NPL, LDR, and Operational Efficiency Ratio against credit distribution. The results show that the partial of five variables that influence are variable Third-party Funds significantly, Capital Adequacy Ratio significantly, and Operational Efficiency Ratio significantly, While variable Non Performing Loan did not influence significantly, and Loan to Deposit Ratio did not influence significantly to credit distribution.
Corporate Governance and the Home Bias

Abstract This paper shows that there is a close relation between corporate governance and the portfolios held by investors. Most firms in countries with poor investor protection are controlled by large shareholders, so that only a fraction of the shares issued by firms in these countries can be freely traded and held by portfolio investors. We show that the prevalence of closely-held firms in most countries helps explain why these countries exhibit a home bias in share holdings and why U.S. investors underweight foreign countries in their portfolios. We construct an estimate of the world portfolio of shares available to investors who are not controlling shareholders (the world float portfolio). The world float portfolio differs sharply from the world market portfolio. In regressions explaining the portfolio weights of U.S. investors, the world float portfolio has a positive significant coefficient but the world market portfolio has no additional explanatory power. This result holds when we control for country characteristics. An analysis of foreign investor holdings at the firm level for Sweden confirms the importance of the float portfolio as a determinant of these holdings.
Enhancing Mucosal-Associated Invariant T (MAIT) cell function and expansion with human selective serum

Mucosal-associated invariant T (MAIT) cells are promising innate-like lymphocytes with potential for use in anti-tumor immunotherapy. Existing MAIT cell expansion protocols are associated with potentially decremental phenotypic changes, including increased frequency of CD4+ MAIT cells and higher inhibitory receptor expression. In this study, we compared the effect on expansion of human MAIT cells of a serum replacement, Physiologix XF SR (Phx), with traditional serum fetal bovine serum (FBS) for supplementing RPMI-1640 media. Using flow cytometry, we found that Phx supported a significantly higher proliferative capacity for MAIT cells and resulted in a lower frequency of CD4+ MAIT cells, which have been associated with reduced Th1 effector and cytolytic functions. We saw that culturing MAIT cells in Phx led to better survival of MAIT cells and lower frequency of PD-1+ MAIT cells compared to FBS-supplemented media. Functionally, we saw that Phx supplementation was associated with a higher frequency of IFN-γ+ MAIT cells after stimulation with E. coli compared to FBS-supplemented RPMI. In conclusion, we show that MAIT cells cultured in Phx have higher proliferative capacity, lower expression of inhibitory receptors, and have higher capacity to produce IFN-γ after E. coli stimulation, compared to FBS-supplemented RPMI. This work shows that expanding MAIT cells with Phx compared to FBS-supplemented RPMI result in a more functionally desirable MAIT cell for future anti-tumor immunotherapy.
No One Dies Alone: Addressing a Gap in Medical Education

Medical school curriculum typically consists of didactical experiences with minimal patient interaction for junior students followed by clinical experiences with supplementary didactics for senior students. Due to the focus on understanding basic medical concepts and disease pathophysiology during the first few years of medical school, students have limited exposure to real-life clinical situations that involve complex, difficult concepts such as death and dying. This leaves students ill-prepared to contribute meaningfully to patients’ end-of-life (EOL) care that they will inevitably encounter during their clerkship years. We believe that students would benefit from increased exposure to these difficult situations through structured educational environments, such as the No One Dies Alone Program. In this way, students can become more familiar with the difficult concepts of death and dying, learn how to make meaningful contributions in their patients’ EOL care, and ultimately provide patients with the “good death” they deserve.
Trends in whitebark pine health in the Greater Yellowstone Ecosystem

Whitebark pine (Pinus albicaulis) contributes to a variety of ecological functions in high-elevation forest communities throughout its range. Recent declines in whitebark pine populations in the Greater Yellowstone Ecosystem have been attributed to a variety of influencing factors including white pine blister rust (Cronartium ribicola), mountain pine beetle (Dendroctonus ponderosae), wildfires, and changes in alpine climatic conditions. We employed data collected by the Interagency Whitebark Pine Monitoring Program from 2004 to 2014 to model blister rust infection probability and the probability of infection transition or expansion from canopy to bole as influenced by tree size 63 (diameter at breast height; DBH) in a tagged population of whitebark pine trees 1 to 20cm DBH. On average, about 35% of trees became infected over a 4-year period. Using generalized linear mixed modelling techniques, we found that initial blister rust infection was positively correlated with DBH. Fifty percent of canopy infected trees showed infection transition from the, to the bole. However, tree size was surprisingly not an important component of infection. Through this effort we provide contemporary data to managing agencies tasked with the preservation and restoration of whitebark pine throughout the ecosystem.
Predictor factors for recurrence in atypical meningiomas

Background and Objectives: Atypical meningiomas (AMs), World Health Organization (WHO) grade 2, are a group of tumors with uneven and unpredictable clinical behavior. Our aim was to analyze possible tumor recurrence predictors, and to identify factors that improve progression-free survival (PFS). Patients, Materials and Methods: Our retrospective study included 81 patients followed up in the Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania, between 1 January 2010 and 31 December 2020. The histopathological specimens were reviewed according to the WHO 2021 criteria. Analyses included clinical, imaging, pathological and surgical factors. Results: The tumor recurred in 53.1% of the 81 cases within 60 months of surgery. Tumor location (p<0.000), tumor volume (p<0.010), extent of surgical resection (p<0.000) and dural sinus invasion (p<0.001) were predictive factors of recurrence. Gross total resection (Simpson grade I and II) was achieved in 59.2% of patients. Patients with the tumors located in the brain convexity and volume <26.4 cm3 had better survival rates up to recurrence. PFS showed a significant relationship between Simpson grade I–III and biopsy (p<0.000) and was statistically influenced by tumor volume and location, and dural sinus invasion. Conclusions: AMs are a heterogeneous group of tumors, and we identified posterior fossa location, volume ≥26.4 cm3, Simpson grade III and IV resection and dural sinus invasion as predictive factors for relapse and a shorter PFS. Whereas certain characteristics provide some prognostic value, future molecular characterizations of AMs are necessary, which will support the clinical decision-making process.
Barriers to and facilitators of human papillomavirus vaccination in an ethnically diverse group of migrant parents: A qualitative mixed methods study

ABSTRACT A disparity in the uptake of the Human papillomavirus vaccine (HPVV) among immigrants and refugees leads to a social gradient in health. Recognizing that immigrants and refugees may encounter unique barriers to accessing prevention and care, this study seeks to determine barriers to and facilitators of HPVV among these subgroups to uncover high-resolution quality improvement targets of investment for under-immunized pockets of the population. The study undertook a qualitative inquiry into understanding immigrant and refugee parents’ perspectives on HPV infection and HPVV experience through school-based programs. We collected data first through short online surveys (N = 15) followed by one-on-one interviews (N = 15) and then through detailed online surveys (N = 16) followed by focus group discussions (N = 3) with 4–6 participants per group discussion from different groups: Black, South Asian and West Asian. Analysis of surveys and interviews identified that: information, awareness, and education about HPV infection and HPVV were among the most cited barriers that impede the uptake of HPVV. Moreover, vaccine-related logistics were equally important, including not having immunization information packages in different languages and relying solely on the child to bring home packages in paper copies from school-based vaccine programs. A multi-component intervention remains instrumental in enhancing HPV immunization rates, given the inconsistent uptake of HPVV by these subgroups who voice unique barriers and facilitators. An educational campaign that involves educating parents who consent for their child(ren) for HPVV, the children receiving the vaccination, and training staff providing HPVV through school-based immunization programs would be paramount.
Defining the short-term and long-term skin manifestations of COVID-19: insights after more than three years of the pandemic

Aim: This review aimed to assess the impact of coronavirus disease 2019 (COVID-19) on skin health to establish a classification of the skin lesions that occur most frequently during the disease and whether a particular category of skin damage is more likely to occur both in the short term and in the long term. Methods: We conducted a literature search of the PubMed database. Ultimately, 109 articles were included in this review. The exact phrases/syntax and connectors used for the database search/query were as follows: “Coronavirus and skin”, “COVID-19 and skin”, “SARS-CoV-2 and skin”, “Coronavirus cutaneous manifestations”, “COVID-19 cutaneous manifestations”, “SARS-CoV-2 cutaneous manifestations”, “Coronavirus dermatology”, “SARS-CoV-2 and dermatology”, “COVID-19 and dermatology”, “COVID-19 and skin eruption”, “Coronavirus and skin rash”, “COVID-19 and hair”, “Coronavirus and hair”, “Coronavirus and nails”, “SARS-CoV-2 and hair”, and “SARS-CoV-2 and nails”. Only articles with abstracts referring strictly to cutaneous manifestations of COVID-19 were chosen. Articles without abstracts were not considered. Results: We established six of the most frequently reported clinical patterns associated with COVID-19 and their probability of occurring during COVID-19 disease evolution based on the current literature reports. We did not identify the particular types of skin lesions that are most prone to long-term persistence; most such cases are rare, and no conclusion can be drawn based on them. Conclusions: Apart from classified COVID-19-related skin disorders, this pandemic has been a challenge for dermatologists and a wide range of cutaneous side effects related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) treatments have been reported. We are aware of other polymorphic clinical presentations, with novel data being reported periodically, but the pathophysiological mechanisms and evolution are largely unknown.
Bayesian Surprise Predicts Human Event Segmentation in Story Listening

Event segmentation theory posits that people segment continuous experience into discrete events and that event boundaries occur when there are large transient increases in prediction error. Here, we set out to test this theory in the context of story listening, by using a deep learning language model (GPT-2) to compute the predicted probability distribution of the next word, at each point in the story. For three stories, we used the probability distributions generated by GPT-2 to compute the time series of prediction error. We also asked participants to listen to these stories while marking event boundaries. We used regression models to relate the GPT-2 measures to the human segmentation data. We found that event boundaries are associated with transient increases in Bayesian surprise but not with a simpler measure of prediction error (surprisal) that tracks, for each word in the story, how strongly that word was predicted at the previous time point. These results support the hypothesis that prediction error serves as a control mechanism governing event segmentation and point to important differences between operational definitions of prediction error.