Miracle-dz/UniFAR-FTUs huggingface dataset:
Cancer Therapy: Preclinical LY2875358, a Neutralizing and Internalizing Anti-MET Bivalent Antibody, Inhibits HGF-Dependent and HGF-Independent MET Activation and Tumor Growth

Purpose: MET, the receptor for hepatocyte growth factor (HGF), has been implicated in driving tumor proliferation and metastasis. High MET expression is correlated with poor prognosis in multiple cancers. Activation of MET can be induced either by HGF-independent mechanisms such as gene amplification, specific genetic mutations, and transcriptional upregulation or by HGF-dependent autocrine or paracrine mechanisms. Experimental Design/Results: Here, we report on LY2875358, a novel humanized bivalent anti-MET antibody that has high neutralization and internalization activities, resulting in inhibition of both HGFdependent and HGF-independent MET pathway activation and tumor growth. In contrast to other bivalent MET antibodies, LY2875358 exhibits no functional agonist activity anddoes not stimulate biologic activities such as cell proliferation, scattering, invasion, tubulogenesis, or apoptosis protection in various HGFresponsive cells and no evidence of inducing proliferation in vivo in a monkey toxicity study. LY2875358 blocks HGF binding to MET and HGF-induced MET phosphorylation and cell proliferation. In contrast to the humanized one-armed 5D5 anti-MET antibody, LY2875358 induces internalization and degradation of MET that inhibits cell proliferation and tumor growth in models where MET is constitutively activated. Moreover, LY2875358 has potent antitumor activity in both HGF-dependent andHGF-independent (METamplified) xenograft tumor models. Together, these findings indicate that the mechanism of action of LY2875358 is different from that of the one-armed MET antibody. Conclusions: LY2875358 may provide a promising therapeutic strategy for patients whose tumors are driven by both HGF-dependent and HGF-independent MET activation. LY2875358 is currently being investigated in multiple clinical studies. Clin Cancer Res; 20(23); 1–12. 2014 AACR.
Immediate Versus Delayed Invasive Intervention for Non-STEMI Patients

RESULTS Median time from randomization to angiography was 1.4 h and 61.0 h in the immediateintervention group and the delayed-intervention group, respectively (p < 0.001). At 30 days, the primary endpoint was achieved less frequently in patients undergoing immediate intervention (4.3% vs. 13%, hazard ratio: 0.32, 95% confidence interval: 0.13 to 0.74; p 1⁄4 0.008). At 1 year, this difference persisted (6.8% in the immediate-intervention group vs. 18.8% in delayed-intervention group; hazard ratio: 0.34, 95% confidence interval: 0.17 to 0.67; p 1⁄4 0.002). The observed results were mainly attributable to the occurrence of new MI in the pre-catheterization period (0 deaths þ 0 MIs in the immediate-intervention group vs. 1 death þ 10 MIs in the delayed-intervention group). The rate of deaths, new MI, or recurrent ischemia was lower in the immediate-intervention group at both 30 days (6.8% vs. 26.7%; p < 0.001) and 1 year (15.4% vs. 33.1%; p < 0.001).
DDDT_A_267400 1021..1029

1Primary Endpoint Solutions, Waltham, MA, 02451, USA; 2Brigham and Women’s Hospital and the Dana-Farber Cancer Institute, Boston, MA, 02215, USA Abstract: Toxicities associated with radiation therapy are common, symptomatically devastating, and costly. The best chance to effectively mitigate radiation-associated normal tissue side effects are interventions aimed at disrupting the biological cascade, which is the basis for toxicity development, while simultaneously not reducing the beneficial impact of radiation on tumor. Oxidative stress is a key initiator of radiation-associated normal tissue injury as physiologic antioxidant mechanisms are overwhelmed by the accumulation of effects produced by fractionated treatment regimens. And fundamental to this is the generation of superoxide, which is normally removed by superoxide dismutases (SODs). Attempts to supplement the activity of endogenous SOD to prevent radiation-induced normal tissue injury have included the administration of bovine-derived SOD and increasing SOD production using gene transfer, neither of which has resulted in a clinically acceptable therapy. A third approach has been to develop synthetic small molecule dismutase mimetics. This approach has led to the creation and development of avasopasem manganese, a unique and specific dismutase mimetic that, in clinical trials, has shown promising potential to reduce the incidence, severity and duration of severe oral mucositis amongst patients being treated with concomitant chemoradiation for cancers of the head and neck. Further, avasopasem and related analogues have demonstrated mechanism-related antitumor synergy in combination with high dose per fraction radiotherapy, an observation that is also being tested in clinical trials. An ongoing Phase 3 trial seeks to confirm avasopasem manganese as an effective intervention for severe oral mucositis associated with chemoradiation in head and neck cancer patients.
NaYS 2 : Er 3 +-a highly e � cient NIR II response multiphoton up-conversion phosphor

Xiumei Yin School of Physics and Materials Engineering, Dalian Minzu University Wen Xu Jilin University Ge Zhu School of Physics and Materials Engineering, Dalian Minzu University Yanan Ji School of Physics and Materials Engineering, Dalian Minzu University Qi Xiao School of Physics and Materials Engineering, Dalian Minzu University Xinyao Dong School of Physics and Materials Engineering, Dalian Minzu University Ming He School of Physics and Materials Engineering, Dalian Minzu University Baosheng Cao School of Physics and Materials Engineering, Dalian Minzu University Na Zhou School of Physics and Materials Engineering, Dalian Minzu University Xixian Luo School of Physics and Materials Engineering, Dalian Minzu University Lin Guo Beihang University Bin Dong (  dong@dlnu.edu.cn ) School of Physics and Materials Engineering, Dalian Minzu University
University of Birmingham Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population

Background: Recent studies have implicated variants of the transcription factor 7-like 2 (TCF7L2) gene in genetic susceptibility to type 2 diabetes mellitus in several different populations. The aim of this study was to determine whether variants of this gene are also risk factors for type 2 diabetes development in a UK-resident South Asian cohort of Punjabi ancestry. Methods: We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, rs7903146, rs11196205 and rs12255372) in 831 subjects with diabetes and 437 control subjects. Results: The minor allele of each variant was significantly associated with type 2 diabetes; the greatest risk of developing the disease was conferred by rs7903146, with an allelic odds ratio (OR) of 1.31 (95% CI: 1.11 – 1.56, p = 1.96 × 10-3). For each variant, disease risk associated with homozygosity for the minor allele was greater than that for heterozygotes, with the exception of rs12255372. To determine the effect on the observed associations of including young control subjects in our data set, we reanalysed the data using subsets of the control group defined by different minimum age thresholds. Increasing the minimum age of our control subjects resulted in a corresponding increase in OR for all variants of the gene (p ≤ 1.04 × 10-7). Conclusion: Our results support recent findings that TCF7L2 is an important genetic risk factor for the development of type 2 diabetes in multiple ethnic groups. Background The search for genes associated with type 2 diabetes mellitus has frequently been complicated by small effect sizes and poor reproducibility between studies. The recent identification of common polymorphisms within the transcription factor 7-like 2 (TCF7L2) gene as risk factors for type 2 diabetes, however, provides fresh hope of unravelling the genetic basis of this complex disease. The association with a microsatellite marker (DG10S478) in intron 3 of TCF7L2 was first reported by Grant et al. [1] in Icelandic subjects and associations with surrogate markers were subsequently confirmed in several other populations Published: 21 February 2008 BMC Medical Genetics 2008, 9:8 doi:10.1186/1471-2350-9-8 Received: 18 July 2007 Accepted: 21 February 2008 This article is available from: http://www.biomedcentral. com/1471-2350/9/8 © 2008 Rees et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Edinburgh Explorer Opportunities and Challenges Surrounding the Use of Data From Wearable Sensor Devices in Health Care

Background: Wearable sensors connected via networked devices have the potential to generate data that may help to automate processes of care, engage patients, and increase health care efficiency. The evidence of effectiveness of such technologies is, however, nascent and little is known about unintended consequences. Objective: Our objective was to explore the opportunities and challenges surrounding the use of data from wearable sensor devices in health care. Methods: We conducted a qualitative, theoretically informed, interview-based study to purposefully sample international experts in health care, technology, business, innovation, and social sciences, drawing on sociotechnical systems theory. We used in-depth interviews to capture perspectives on development, design, and use of data from wearable sensor devices in health care, and employed thematic analysis of interview transcripts with NVivo to facilitate coding. Results: We interviewed 16 experts. Although the use of data from wearable sensor devices in health and care has significant potential in improving patient engagement, there are a number of issues that stakeholders need to negotiate to realize these benefits. These issues include the current gap between data created and meaningful interpretation in health and care contexts, integration of data into health care professional decision making, negotiation of blurring lines between consumer and medical care, and pervasive monitoring of health across previously disconnected contexts. Conclusions: Stakeholders need to actively negotiate existing challenges to realize the integration of data from wearable sensor devices into electronic health records. Viewing wearables as active parts of a connected digital health and care infrastructure, in which various business, personal, professional, and health system interests align, may help to achieve this. (J Med Res
Relation Extraction on Swedish Text by the Use of Semantic Fields and Deep Multi-Channel Convolutional Neural Networks

This thesis makes two contributions to the research domain of relation extraction (RE), i.e., the automated discovery of semantic links in unstructured text. The first contribution is a method for creating a dataset for RE, and using it to create the first Swedish RE dataset involving nine relationships between persons, locations and vehicles. The second contribution is a variety of experiments on this new dataset providing baselines. The relation extraction systems created in this thesis include deep multi-channel convolutional neural networks, and Word2Vec embeddings. A manual labeling of a subset of our data shows an accuracy of 73%. We find that using a discrete representation of part-of-speech and dependency tags in the multi-channel convolutional network yields the best performance with a micro-average F1-score of 77%. The thesis discusses a variety of problems and future avenues of research, including the underlying motivation of this work: the automatic summarization of police reports in Sweden.
PREVALENCE AND ASSESMENT OF MALNUTRITION AND ASSOCIATED FACTORS AMONG CHILDREN (6-59) MONTHS IN FTEEHALAGALEEN, KHARTOUM STATE, SUDAN, 2017

The term malnutrition includes three broad groups of conditions: Under nutrition which includes wasting (low weight for height), stunting (low height for age) and underweight (low weight for age), Micronutrient–related malnutrition which includes micronutrient deficiencies (a lack of important vitamins and minerals) or micronutrient excess and overweight –obesity and diet related on communicable diseases.
Displaced proximal humerus fractures treated with ORIF via the deltoid interfascicular approach vs the deltopectoral approach

Abstract Background: The purpose of this study was to evaluate the clinical outcomes and complications of displaced proximal humeral fractures treated with proximal humeral internal locking system (PHILOS) plate fixation via a deltoid interfascicular (DI) vs a deltopectoral (DP) approach. Methods: This prospective case-control study was conducted with patients admitted to our hospital from May 2015 to June 2018 who suffered from unilateral displaced proximal humerus fractures. Patients were treated with PHILOS plate fixation via a DI (DI group) or DP approach (DP group). The clinical outcomes and complication data were collected for comparison between the 2 groups. The patients were followed up at 3, 6, and 12 months; and every 6 months thereafter. The patients’ functional recoveries were evaluated according to the normalized Constant-Murley score, range of motion of the shoulder (flexion, abduction, external/internal rotation) and disabilities of the arm, shoulder and hand score. Results: A total of 77 patients, followed for an average of 15 ± 2.2months (range, 12–21), were enrolled (36 in DI group and 41 in DP group) for final analysis. No significant differences in age, sex, affected side, fracture type, injury mechanism or time from injury to operation were found between the 2 groups (all P > .05). The incision length, intra-operative blood loss, and duration of operation in the DI group were significantly less than those in the DP group, respectively (all P < .05). The functional outcomes assessed by the normalized Constant-Murley score and range of motion of flexion and internal rotation in the DI group were superior to those in the DP group at 3 and 6months after the operation (P < .05); however, no significant differences were observed at the 12-month and subsequent follow-ups (all P > .05). There was no significant difference in the range of shoulder external rotation and abduction during the postoperative follow-ups (P > .05). At the last follow-up, the mean disabilities of the arm, shoulder, and hand score was 14.0 (6.6) points in the DI group and 14.4 (6.9) points in the DP group (P = .793). Complications occurred in 1 patient in the DI group and 8 patients in the DP group (P = .049). Conclusion: The current study demonstrates that DI approach is a safe and effective alternative for the treatment displaced proximal humerus fractures. The DI approach rather than DP approach was recommended when lateral and posterior exposure of the proximal humerus is required, especially when fixed with PHILOS plate.
Connecting Higher Education to Industry: A Critical reflection on Swedish and Iranian HE Policies and Practices

In recent years the importance of collaboration between higher education and industry has been increasingly acknowledged by HE’s policymakers and scholars and different national policies and practices all around the world have been carried out to bridge these two parties effectively. Although developing countries have realized the importance and necessity of university-industry collaboration, yet they are confronting a deep-rooted mismatch between universities and industry. This paper however, aims to critically analyze and compare relevant current mechanisms, policies and practices in Iran and Sweden. As multiple qualitative approach was used to enable deep exploration of participants. Participants included 29 Iranian and Swedish experts representing universities and industries who were purposefully selected and were interviewed using semi-structure interview. Data was analyzed via the coding method (open coding, axial coding and selective coding). Findings revealed that Iran and Sweden use two relatively different models to fill the gap between their universities and industries emphasizing on different aspects and players. Despite some similarities between these two countries in their approaches to link universities to the industry, the findings showed that in contrast to Iranian triple model in Sweden a five-way model is applied for university-business collaboration (UBC). Findings also show that despite the reported needs for close cooperation between universities and industries in Iran, current policies and methods, including the types of relationships and interactions and strategies used, need to be critically reviewed. In addition, given the findings on Swedish policies and methods for connecting universities and industries, some practical strategies have been proposed to improve the relationship between universities and industries in Iran.
Prevalence and Risk Factors of Birth Asphyxia among Elderly Gravidarum

Objectives: To investigate the prevalence and risk factors of birth asphyxia in pregnancies with advanced maternal age. Materials and Methods: This study involved a retrospective cohort with a nested case-controlled study. Data were collected at Rajavithi Hospital. The prevalence of birth asphyxia was investigated using a retrospective cohort study of cases from January 2012 to June 2016. Antepartum factors, intrapartum factors and postpartum and newborn factors were studied using a nested casecontrolled approach that involved the random matching and analysis of the results according to these factors. Results: The prevalence of birth asphyxia of advanced maternal age group in this study was 11.7%. The statistically significant risk factors included number of antenatal care (ANC) < 4 visits (adjusted OR 1.64, 95% CI 1.18-2.26), hypertensive disorders (adjusted OR 1.94, 95% CI 1.42 -2.65), placenta previa (adjusted OR 4.58, 95% CI 2.74-7.68), PROM > 18 hours (adjusted OR 3.71, 95% CI 1.98 – 6.98), non-cephalic presentation (adjusted OR 1.95, 95% CI 1.34-2.84), and non-reassuring intrauterine fetal status (adjusted OR 3.35, 95% CI 2.22-5.06). There were no significant risk factor at diabetes disorders (95%CI 0.84-1.42, p = 0.50), meconium stained amniotic fluid (95%CI 0.64-1.73, p = 0.830), administration of analgesic drug (95%CI 0.59-1.91, p = 0.839), and nuchal cord (95%CI 0.59-1.27, p = 0.453). Conclusion: Birth asphyxia at Rajavithi Hospital was 11.7%. The statistically significant risk factors associated with birth asphyxia were number of ANC < 4 visits, hypertensive disorders, placenta previa, a PROM > 18 hours, non-cephalic presentation, and nonreassuring fetal status or fetal distress.
Prioritizing the solutions of lean implementation in SMEs to overcome its barriers

Purpose The implementation of lean production in small manufacturing enterprises (SMEs) harbors a great deal of barriers on practical, theoretical, financial and organizational sides. In view of this, the purpose of this paper is to explore and prioritize the solutions to overcome these barriers and pitfalls in order to identify a list of the most feasible and efficient solutions on which SMEs must focus to success their lean journey. Design/methodology/approach First, a review of the published articles along with the interview of some lean experts have allowed to identify 20 barriers grouped into five categories along with 17 solutions proposed to overcome these barriers. Afterwards, an integrated fuzzy Analytic Hierarchy Process-Technique for Order Preference by Similarity to Ideal Solution (AHP-TOPSIS) was proposed to evaluate and rank the solutions of lean implementation in SMEs and overcome its barriers. The AHP is used to determine weights of the barriers as criteria, and the fuzzy TOPSIS method is used to determine the final ranking of the solutions of lean adoption in SMEs. Findings The top five barriers of lean implementation in SMEs were found to be: lack of management involvement, lack of adapted methodology of lean implementation, short-term vision, fear and resistance to change and lack of understanding of lean. Moreover, the top five solutions to overcome the barriers of lean adoption in SMEs are as follows: commitment and participation of management, adoption of simple measurement and KPIs, development of organizational learning culture, early deployment of lean culture through training and allocation of sufficient time and resources for change. Originality/value The findings of this study can provide a basis for researchers and practitioners in order to understand the real reasons of lean failure in SMEs and develop improvement plans to increase its success rate. Moreover, it proposes a more reliable, robust and systematic decision support tool for stepwise implementation of the solutions of lean adoption in SMEs since they lack sufficient resources to address all the solutions simultaneously.
Issues with using Landsat based Surface Temperature for Investigating Linkage between Local Climate Zones and Surface Urban Heat Island in Different Seasons: A Case Study of Manhattan, N.Y

This study was conceptualized to investigate differences in surface temperature profile of Local Climate Zones (LCZ) classes in different seasonal conditions. Manhattan was selected as case study due to its dense, but heterogeneous built-up profile and presence of green area which formed the baseline for temperature comparison. However, this study failed to find significant results, in terms of the distinct Urban Heat Island (UHI) feature often reported in literature. Instead, this study suggests that in the case of Manhattan UHI is predominantly within ± 0.5 C° except during summer season. In summer season, where more difference in built and green LCZ is observed, the noise in data, defined by standard deviation of surface temperature in the class, is also higher. Thus, our study concludes that Landsat based surface temperature should be used with extreme caution to investigate UHI since most imagery is taken during day time.
Changes in Amino Acid and Nucleotide Pools of Rhodospirillum rubrum during Switch-Off of Nitrogenase Activity Initiated by NH 4 + or Darkness

Amino acid and nucleotide pools were measured in nitrogenase-containing Rhodospirillum rubrum cultures during NH4+or dark-induced inactivation (switch-off) of the Fe protein. A big increase in the glutamine pool size preceded NH4+ switch-off of nitrogenase activity, but the glutamine pool rqmained unchanged during dark switch-off. Furthermore, methionine sulfoximine had no effect on the rate of dark switch-off, suggesting that glutamine plays no role in this process. In the absence of NH4' azaserine, an inhibitor of glutamate synthate, raised glutamine pool levels sufficiently to initiate switch-off in vivo. While added NH4L substantially increased the size of the nucleotide pools in N-limited cells, the kinetics of nucleotide synthesis were all similar and followed (rather than preceded) Fe protein inactivatioi. Darkness had little effect on nucleotide pool sizes. Glutamate pool sizes were also found to be important in NH4' switch-off because of the role of this molecule as a glutamine precursor. Much of the diversity reported in the observations on NH4' switch-off appears to be due to variations in glutamate pool sizes prior to the NH4+ shock. The nitrogen nutritional background is an important factor in determnining whether darkness initiates nitrogenase switch-off; however, no link has yet been established between this and NH4' (glutamine) switch-off.