Miracle-dz/UniFAR-FTUs huggingface dataset:
A flavonoid derivative of icariside II (YS-10) improves erectile dysfunction in radiation-injured rats via oxidative stress pathway

Background We explored the preventive effect and mechanism of YS-10, a novel synthesized flavonoid derivative based on the structure of icariside II (ICA II), on a rat model of radiation-induced erectile-dysfunction (Ri-ED). Methods Eighteen 10-week-old male Sprague-Dawley (SD) rats were randomly divided into 3 groups. Six rats were used as the control group (Control), and the remaining 12 were given a single X-ray irradiation of 20 Gy in the prostate and then randomly divided into the radiation injury group (Ri-ED group) and YS-10 treatment group (Ri-ED+YS-10, 2.5 mg/kg/day). After 4 weeks of drug administration and a 2-week drug washout period in the YS-10 treatment group, the erectile function of the animals was evaluated, and the tissues were collected for histopathological analysis and detection of oxidative stress indicators. Results After radiation injury, the ratio of maximum intracavernosal pressure (ICP) to mean arterial pressure (MAP), the number of neuronal nitric oxide synthase (n-NOS) positive nerve fibers in the penis cavernosa, endothelial cell content, and n-NOS and endothelial nitric oxide synthase (e-NOS) proteins in the Ri-ED group were significantly lower than those in control group. Compared with the control group, the Ri-ED group had lower superoxide dismutase (SOD) levels and higher malondialdehyde (MDA) levels. Compared with the Ri-ED group, the YS-10 group had a significant increase in the ratio of ICP/MAP in the corpus cavernosum (0.59±0.06 vs. 0.43±0.06, P<0.01), the number of n-NOS positive nerve fibers, and the content of endothelial cells. The protein content of n-NOS and e-NOS in the corpus cavernosum increased and could significantly reduce the level of MDA (2.67±0.27 vs. 3.25±0.21, P<0.05). Conclusions As a novel ICA II derivative, YS-10 could significantly improve the erectile dysfunction and pathological damage in rats caused by radiation injury, and its mechanism may be related to the improvement of radiation-induced oxidative stress.
Assessing the effect of persuasive robots interactive social cues on users’ psychological reactance, liking, trusting beliefs and compliance

ABSTRACT Research in the field of social robotics suggests that enhancing social cues in robots can elicit more social responses in users. It is however not clear how users respond socially to persuasive social robots and whether such reactions will be more pronounced when the robots feature more interactive social cues. In the current research, we examine social responses towards persuasive attempts provided by a robot featuring different numbers of interactive social cues. A laboratory experiment assessed participants’ psychological reactance, liking, trusting beliefs and compliance toward a persuasive robot that either presented users with: no interactive social cues (random head movements and random social praises), low number of interactive social cues (head mimicry), or high number of interactive social cues (head mimicry and proper timing for social praise). Results show that a persuasive robot with the highest number of interactive social cues invoked lower reactance and was liked more than the robots in the other two conditions. Furthermore, results suggest that trusting beliefs towards persuasive robots can be enhanced by utilizing praise as presented by social robots in no interactive social cues and high number of interactive social cues conditions. However, interactive social cues did not contribute to higher compliance. GRAPHICAL ABSTRACT
IMPROVING BROILER PERFORMANCE BY SUPPLEMENTING DIETS WITH DIFFERENT PROBIOTIC AND SYMBIOTIC PREPARATIONS

An experiment involving 225 unsexed Hubbard broiler chicks was conducted for 35 days to determine the effects of varying probiotic ad symbiotic preparations on their growth performance, carcass traits, intestinal bacteria count and blood parameters (5 treatments, 3 replicates with 15 chicks per replicate). The treatments were, the basal diet without additives (control, T1), the basal diet with addition of symbiotic preparation (250g/ton) lacto-Pro, (T2), Bacillus-fort, (T3), Balacto, (T4) and probiotic preparation 500g/ton Zado, (T5). The results revealed that:  Different probiotic and symbiotic preparations (T2-5) significantly increased BWG more than 18% (2284.90 g vs1937.40 g.) as well as FI (3276.25g vs. 2833. 75) and improved FCR from 1.43 vs 1.46 in comparison to the control. The best value was for T4.  No significant differences were observed among treatments on carcass traits or lymphoid organs.  Treatments 2-5 decreased pathogenic bacteria (E.coli and Salmonella) and increased beneficial bacteria (Bacillus subtilis, and Lactobacillus)in the small intestine as compared with the control, T1.  Plasma Total protein, and Albumin were significantly affected by dietary treatment. In conclusion, probiotic and symbiotic supplementation to broiler diets had beneficial positive effects on productive performance and microorganisms in the small intestine.
The Big Five Personality and Perception of the Career Barriers of Male Prisoners: Moderated Mediating Effect Models

Prisoners’ employment has received widespread attention from society. In this study, based on career construction theory and social cognitive career theory, 300 male prisoners were selected as the research sample, and questionnaires were used for data collection. The results show that in the relationships between extroversion, openness, neuroticism, and perception of career barriers, and prisoners’ career adaptability plays a mediating role. When extroversion, openness, and neuroticism are predictor variables, the socioeconomic status of prisoners plays a moderating role in the predictive effect of career adaptability on the perception of career barriers. Specifically, compared with individuals with low and medium socioeconomic statuses, the negative effect of career adaptability on the perception of career barriers was stronger at high socioeconomic status levels.
Anti-SARS-CoV-2 Vaccination Campaign: Risk Perception, Emotional States, and Vaccine Hesitancy in a Sample of Adolescents’ Vaccinated Parents in Southern Italy

Background: The international strategic plan for COVID-19 vaccines remains the practical option for the protection of health. However, vaccine hesitancy remains an obstacle to full population vaccination, with rapid developments in COVID-19 vaccines and concerns about efficacy acting as influencing factors. Aim: The present study investigated the perception of vaccine hesitancy among parents of adolescents in order to explore the reasons and related emotional states. Methods: In January–March 2022, an online questionnaire was administered to a sample of parents who brought their children to the vaccine center of a local health unit, ASL Salerno (Campania, Italy). Results: The participants were 1105 parents (F = 64.6%; mean age = 47.37 years, SD = 7.52) of adolescents (F = 47.6%; mean age = 14.83 years, SD = 1.72). All parents had received the COVID-19 vaccine. Regarding the vaccination schedule, 46.8% believed that children receive more vaccinations than they should; 25.1% believed that it is better to develop immunity rather than get vaccinated; 41.2% believed that their child could have side effects; 29.6% were very concerned that vaccines were unsafe, while 35.3% believed vaccines do not prevent disease; 21.5% were very reluctant about pediatric vaccines; and 23.8% did not trust the information received. Conclusions: In order to increase vaccination and reduce the prevalence of vaccine hesitancy, it is essential to support the value of vaccination among all parents and make information more accessible and usable through competent pediatricians.
Why Not Use the Sea? A Shared Value Approach to Sustainable Value Creation When Using Carbon Dioxide as a Valuable Resource in Manufacturing

Interest on the creation of sustainable value has recently increased as a response to global issues caused by traditional business-as-usual logic. Indeed, corporations pursuing profits and competitive advantage at the expense of social and environmental resources has become a source of pressing concern and institutionalized unsustainability needs to be reversed. To create sustainable value, a paradigm shift is required in who benefits from value creation: beyond customers, suppliers, and business partners, value should be created for an expanded range of stakeholders including governmental and non-governmental entities, local communities, and future generations. This study refers to unique value creation derived from business modeling for sustainability and the stakeholder theory perspective as a theoretical lens for understanding how sustainable shared value is created in the context of carbon capture and utilization. Using an exploratory, in-depth single case study of a microalgae cultivation project, the study gathers empirical evidence to show how engaging stakeholders around a common purpose can serve as a path to open new business opportunities for sustainable shared value. This study challenges the Friedman's assertion of shareholder profits and shows evidence of the power of creating shared value if a company adopts a purpose beyond profits. Through empirical findings on how embedding a sustainable purpose at the core can lead to business opportunities that provide shared value for multiple stakeholders, it outlines how a company can obtain value propositions that cater to economic, environmental, and societal balance in the drive to move toward a more sustainable society. This study thus contributes to the growing body of empirical literature on creating shared value and business models for sustainability. The findings are also relevant for various industry practitioners, presenting insights on sustainable value creation and business modeling for an industry plagued by high emissions and stakeholder pressure to do good.
The Influence of Principal's Democratic Leadership Style on Teacher Performance

Teacher competencies play an important role in determining the success of an institution. To improve teacher performance, the principal should utilize a leadership style that promotes teachers’ competence, growth, and development. This study analyzed the effect of a principal’s democratic leadership style on teacher performance. A systematic review was conducted by analyzing articles on related topics published between 2017 and 2022 and accessed from lens.org, Google Scholar, and Science Direct. The results pointed out that the democratic leadership style gives broad authority to subordinates. Leaders who use a democratic leadership style delegate duties and responsibilities well to their subordinates, and all members are invited to participate in discussions or propose their opinions on strategies directed toward the common goal. Therefore, the principal’s democratic leadership style can influence and improve teacher performance. Keywords: principal, democratic leadership, teacher performance
Development of a High Oleic Cardoon Cell Culture Platform by SAD Overexpression and RNAi-Mediated FAD2.2 Silencing

The development of effective tools for the sustainable supply of phyto-ingredients and natural substances with reduced environmental footprints can help mitigate the dramatic scenario of climate change. Plant cell cultures-based biorefineries can be a technological advancement to face this challenge and offer a potentially unlimited availability of natural substances, in a standardized composition and devoid of the seasonal variability of cultivated plants. Monounsaturated (MUFA) fatty acids are attracting considerable attention as supplements for biodegradable plastics, bio-additives for the cosmetic industry, and bio-lubricants. Cardoon (Cynara cardunculus L. var. altilis) callus cultures accumulate fatty acids and polyphenols and are therefore suitable for large-scale production of biochemicals and valuable compounds, as well as biofuel precursors. With the aim of boosting their potential uses, we designed a biotechnological approach to increase oleic acid content through Agrobacterium tumefaciens-mediated metabolic engineering. Bioinformatic data mining in the C. cardunculus transcriptome allowed the selection and molecular characterization of SAD (stearic acid desaturase) and FAD2.2 (fatty acid desaturase) genes, coding for key enzymes in oleic and linoleic acid formation, as targets for metabolic engineering. A total of 22 and 27 fast-growing independent CcSAD overexpressing (OE) and CcFAD2.2 RNAi knocked out (KO) transgenic lines were obtained. Further characterization of five independent transgenic lines for each construct demonstrated that, successfully, SAD overexpression increased linoleic acid content, e.g., to 42.5%, of the relative fatty acid content, in the CcSADOE6 line compared with 30.4% in the wild type (WT), whereas FAD2.2 silencing reduced linoleic acid in favor of the accumulation of its precursor, oleic acid, e.g., to almost 57% of the relative fatty acid content in the CcFAD2.2KO2 line with respect to 17.7% in the WT. Moreover, CcSADOE6 and CcFAD2.2KO2 were also characterized by a significant increase in total polyphenolic content up to about 4.7 and 4.1 mg/g DW as compared with 2.7 mg/g DW in the WT, mainly due to the accumulation of dicaffeoyl quinic and feruloyl quinic acids. These results pose the basis for the effective creation of an engineered cardoon cells-based biorefinery accumulating high levels of valuable compounds from primary and specialized metabolism to meet the industrial demand for renewable and sustainable sources of innovative bioproducts.
Characteristics and Prognosis of Antibody Non-responders With Coronavirus Disease 2019

Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been spreading globally. Information regarding the characteristics and prognosis of antibody non-responders to COVID-19 is limited. Methods In this retrospective, single-center study, we included all patients with confirmed COVID-19 using real-time reverse transcriptase-polymerase chain reaction (RT-PCR) admitted to the Fire God Mountain hospital from February 3, 2020, to April 14, 2020. A total of 1,921 patients were divided into the antibody-negative (n = 94) and antibody-positive (n = 1,827) groups, and 1:1 propensity score matching was used to match the two groups. Results In the antibody-negative group, 40 patients (42.6%) were men, and 49 (52.1%) were older than 65 years. Cough was the most common symptom in the antibody negative group. White blood cell counts, neutrophils, C-reactive protein, procalcitonin, interleukin-6, lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme, urea nitrogen, and creatinine were significantly higher in the antibody-negative patients than in the antibody-positive group (P < 0.005). The number of days of nucleic acid-negative conversion in the antibody-negative group was shorter than that in the antibody-positive group (P < 0.001). The hospitalization time of the antibody-negative patients was shorter than that of the antibody-positive patients (P < 0.001). Conclusion Some COVID-19 patients without specific antibodies had mild symptoms; however, the inflammatory reaction caused by innate clinical immunity was more intense than those associated with antibodies. Non-specific immune responses played an essential role in virus clearance. There was no direct correlation between excessive inflammatory response and adverse outcomes in patients. The risk of reinfection and vaccination strategies for antibody-negative patients need to be further explored.
Factors Affecting Audit Opinion Going Concern

This study discusses the effect of firm size, leverage, profitability, liquidity, and audit quality on going concern audit opinions. The sample of this study was obtained using a purposive sampling method with a focus on manufacturing companies listed on the Indonesia Stock Exchange for the 2018-2020 period. Furthermore, this study applied a purposive sampling technique which resulted in 50 companies with a total of 150 research samples. Then the hypothesis is tested by applying logistic regression. Based on the findings of the analysis, it is known that the audit quality variable has a positive effect on going-concern audit opinion. While the variables of firm size, leverage, profitability, and liquidity have no effect on going concern audit opinion
The Effect of Off-Angle Spraying on the Structure and Properties of HVOF WC/CoCr Coatings

The aerospace industry currently applies high velocity oxy-fuel (HVOF) coatings to turbine engine, structural, and landing gear components. An increasing demand for HVOF wear resistant coatings to replace electrolytic hard chrome (EHC) on landing gear components has renewed focus on the spray limitations of HVOF WC/CoCr. One such limitation resulting from the line-of-sight HVOF process is the spray angle. In this study, HVOF WC/CoCr coatings were sprayed at several angles while maintaining consistent combustion characterisitics and standoff distance. The measured responses included tensile bond strength, microhardness, residual stress, coating surface roughness, and dry fretting wear resistance. Fatigue response was also of interest, but no results were available at the time this paper was written. The microstructure of each coating was examined, both normal to the surface and in cross section. Coatings sprayed at 90° exhibited the highest microhardness and most compressive residual stress, both considered favorable for good wear response. But these coatings also exhibited the highest as-sprayed roughness, least homogeneous microstructure normal to the surface, and lower wear resistance compared to the off-angle coatings; however, the off-angle coatings apear to cause greater wear of the contacting surface. The microstructural differences among the coatings are related to the measured responses.
Modification of a Lateritic Soil with Lime and Cement: An Economical Alternative for Flexible Pavement Layers

Lateritic soils are widely spread in the Brazilian territory and they have been used as subgrade of pavement layers. Specifically, the Red-yellow latosols are usually clayey soils and are characterized as low bearing capacity materials for flexible pavement layers. As a conventional solution, soil stabilization with hydrated lime or Portland cement has been used as pavement layers reinforcement. However, the addition of low contents of stabilizers, referring to the soil modification, has not been applied on regular basis in highway designs. The purpose of this paper is to evaluate the use of low contents of lime and cement in the modification of a lateritic soil properties concerning the behavior of mixtures since of the beginning of construction to the resulting final product. At this point, the workability, chemical properties, mechanical behavior and mineralogical composition were evaluated. Mechanistic analyses were performed in order to verify fatigue failures on asphalt layers in roadways structural layers. Experimental results showed that addition of 2% and 3% of lime or cement was enough to change the soil workability and mechanical strength. Additionally, mechanistic analyses supported the soil modification technique as valuable practice with low elastic strains in the asphalt layer when applied in pavement base layers.
The economic geography of European Union’s discontent: Lessons from Greece

The regions of the European Union are currently experiencing a period of seismic change that has transformed their established voting patterns and increased anti–European Union voting. Applying objective economic measures, spatial econometrics and municipal voting data from recent elections and a referendum, this study examines the factors shaping anti–European Union votes in Greece. The results indicate a strong link between the country’s changing economic geography and the geography of the anti–European Union vote, providing evidence not only of the ‘geography of discontent’ and the ‘left-behind hypothesis’ but also of the ‘geography of austerity’ associated with the heterogeneous effects of fiscal consolidation and austerity policies.
Atributos essenciais da atenção Primária e a estratégia Saúde da família

The essential attributes of Primary Health Care are attention at first contact, longitudinality, completeness and coordination, and the derived attributes are family and community orientation and cultural competence. This paper discusses the presence of such attributes in Family Health Strategy, a political and governmental proposal to change the health care model in the context of the Unified Health System in Brazil. descriptors: Health Policy; Primary Health Care; Family Health.
Dual Effect of the Extract from the Fungus Coriolus versicolor on Lipopolysaccharide-Induced Cytokine Production in RAW 264.7 Macrophages Depending on the Lipopolysaccharide Concentration

Purpose Extract from the fungus Coriolus versicolor (CV) is classified as an immunological response modifier. Previously, we have shown that this extract induces interleukin 6 (IL-6)-related extension of lipopolysaccharide (LPS)-induced fever. This study investigated the effect of CV extract on the production of pro-inflammatory cytokines and the expression of components of signal transduction pathways leading to the secretion of cytokines from RAW 264.7 macrophages stimulated with different doses of LPS. Methods RAW 264.7 cells were stimulated with CV extract alone or co-treated with CV extract and LPS. The level of IL-6 and tumour necrosis factor α (TNF-α) in the culture media was measured using ELISA. Protein expression of Toll-like receptor (TLR) 4, phosphorylated IκB (p-IκB), CD14 glycoprotein and phospho-phosphatidylinositol 3-kinase (p-PI3K) was evaluated using Western blot. The effects of TLR4, nuclear factor κB (NF-κB) and p-PI3K on cytokine secretion were estimated using inhibitors: TAK-242, JSH-23 and LY294002. Results CV extract itself stimulates the secretion of IL-6 and TNF-α and increases the expression of TLR4, p-IκB and p-PI3K. The presence of CV extract during the treatment of cells with lower concentrations of LPS (10 and 100 ng/mL) increases the cytokine production. Co-stimulation of cells with CV extract and LPS at a higher dose (500 ng/mL) decreases the secretion of cytokines. This effect is related to the changes in the expression of TLR4, CD14 glycoprotein, p-IκB and p-PI3K. Conclusion This is the first report showing that the CV extract-induced production of cytokines is mediated by the PI3K signalling pathway. This extract acts antagonistically or additively with LPS on the production of IL-6 and TNF-α, depending on the LPS concentration. Our results are helpful for illustrating the mechanisms for the immunostimulatory effect of CV extract in inflammatory processes.
Ideals and simplicity of crossed products of graph C-algebras by quasi-free actions

Let E be a row-finite directed graph without sinks, let G be a locally compact abelian group with dual group Γ, and let ω be a labeling map, then, as defined by the second author in [16], one has the quasi-free action αω of G on the graph C-algebra C(E). In this paper, we introduce the notion of E-class of subsets of Γ, and using this, obtain a description of the gauge-invariant ideal structure and also a characterization of simplicity for the crossed product C-algebra C∗(E)×αω G in the case of a row-finite directed graph E without sinks. Moreover, if the labeling map ω is in-phase and each loop in E has an exit, we prove that every ideal of the crossed product is gauge invariant.