Miracle-dz/UniFAR-FTUs huggingface dataset:
Strengthening urban primary healthcare service delivery using electronic health technologies: A qualitative study in urban Nepal

Background Nepal is a South Asian country with a high burden of non-communicable diseases. Electronic health technologies are a promising strategy to mitigate the rising burden of non-communicable diseases by strengthening primary healthcare center service delivery. However, electronic health implementation in Nepal is limited. Furthermore, electronic health use at the primary healthcare center level is chronically understudied. This qualitative study seeks to understand the perceived awareness, benefits, and determinants of electronic health uptake in Nepal, focusing on primary healthcare center-level non-communicable disease management. Methods We conducted in-depth interviews with 27 participants including policymakers, health experts, facility administrators, providers, and non-communicable diseases patients in 2019. We selected six urban primary healthcare center facilities via cluster convenience sampling for recruiting facility administrators, providers, and patients, and used convenience sampling to recruit policymakers and experts. We conducted thematic data analysis inductively and deductively using the electronic health readiness assessment framework to understand perceived barriers and facilitators of electronic health implementation. Results While there was general awareness and acceptance of electronic health, multiple barriers impede readiness for implementation. These include policy making gaps, language barriers, low user technical literacy, concerns of overreliance on technology, and inadequate training for administrators and providers. Stakeholder suggestions include creating electronic health interfaces that meet the needs of end users (providers and patients), providing training to enable end users to effectively use electronic health technologies, and strong policy support at the national level. Conclusion We identify several determinants for effectively promoting the use of electronic health for non-communicable diseases service delivery at the primary healthcare center level in Nepal.
Study on the Formation Mechanism of Cutting Dead Metal Zone for Turning AISI4340 with Different Chamfering Tools

Tools with chamfered edges are often used in high speed machining of hard materials because they provide compelling cutting toughness and reduced tool wear. Chamfered tools are also responsible for the dead metal zone (DMZ). Through numerical simulation of orthogonal cutting with AISI 4340 steel, this paper examines the mechanism of the DMZ, the cutting speed, the impacts of the chamfer angle, and the coefficient of friction on the generation of the DMZ. The analysis is based upon the Arbitrary Lagrangian-Eulerian (ALE) finite element method (FEM) for the continuous process of chip formation. The different chamfered angles, cutting speeds, and friction coefficient conditions are utilized in the simulation. The research demonstrates that a zone of trapped material called DMZ has been formed beneath the chamfer and serves as an effective cutting edge of the tool. Additionally, the dead metal zone DMZ becomes smaller while the cutting speed increases or the friction coefficient decreases. The machining forces rise with increasing chamfer angles, rise with increasing friction coefficients, and fall with increasing cutting speed in both the cutting and thrust directions. In this paper, the effect of different chamfering tools on AISI 4340 steel using carbide tools in the simulation environment is studied. It has certain reference significance for studying the formation mechanism of the dead zone of difficult-to-machine materials such as AISI4340 and improving the processing efficiency and workpiece surface quality.
ANALISIS HUBUNGAN INFLASI, PMA, PENYERAPAN TENAGA KERJA DAN PERTUMBUHAN EKONOMI INDONESIA

This study examined the relationship between inflation, foreign investment (FDI), and employment with economic growth. This study used secondary data from 1990 to 2020. The data were analyzed using the vector autoregression (VAR) analysis method. The results showed that inflation had no significant effect on economic growth. Vice versa, economic growth had no significant effect on inflation. FDI had a negative and significant effect on economic growth. Furthermore, economic growth had no significant effect on FDI. The absorption of labor did not have a significant effect on economic growth. Vice versa, economic growth had no significant effect on employment. The government should strengthen the applicable regulations, especially regulations regarding FDI to make a more positive contribution to economic growth.
Prospective Associations of Lifetime Post-traumatic Stress Disorder and Birth-Related Traumatization With Maternal and Infant Outcomes

Objective Many women experience traumatic events already prior to or during pregnancy, and delivery of a child may also be perceived as a traumatic event, especially in women with prior post-traumatic stress disorder (PTSD). Birth-related PTSD might be unique in several ways, and it seems important to distinguish between lifetime PTSD and birth-related traumatization in order to examine specific consequences for mother and child. This post-hoc analysis aims to prospectively examine the relation of both, lifetime PTSD (with/without interpersonal trauma) and birth-related traumatization (with/without postpartum depression) with specific maternal and infant outcomes. Methods In the prospective-longitudinal Maternal in Relation to Infants' Development (MARI) study, N = 306 women were repeatedly assessed across the peripartum period. Maternal lifetime PTSD and birth-related traumatization were assessed with the Composite International Diagnostic Interview for women. Maternal health during the peripartum period (incl. birth experience, breastfeeding, anxiety, and depression) and infant outcomes (e.g., gestational age, birth weight, neuropsychological development, and regulatory disorders) were assessed via standardized diagnostic interviews, questionnaires, medical records, and standardized observations. Results A history of lifetime PTSD prior to or during pregnancy was reported by 25 women who indicated a less favorable psycho-social situation (lower educational level, less social support, a higher rate of nicotine consumption during pregnancy). Lifetime PTSD was associated with pregnancy-related anxieties, traumatic birth experience, and anxiety and depressive disorders after delivery (and in case of interpersonal trauma additionally associated with infant feeding disorder). Compared to the reference group, women with birth-related traumatization (N = 35) indicated numerous adverse maternal and infant outcomes (e.g., child-related fears, sexual problems, impaired bonding). Birth-related traumatization and postpartum depression was additionally associated with infant feeding and sleeping problems. Conclusion Findings suggest that both lifetime PTSD and birth-related traumatization are important for maternal and infant health outcomes across the peripartum period. Larger prospective studies are warranted. Implications Women with lifetime PTSD and/or birth related traumatization should be closely monitored and supported. They may benefit from early targeted interventions to prevent traumatic birth experience, an escalation of psychopathology during the peripartum period, and adverse infant outcomes, which in turn may prevent transgenerational transmission of trauma in the long term.
Finite Element Simulation of Punch Shear during Hole Piercing in Auto Chain Components

The capabilities of presses are sometimes limited due to larger cutting force requirement for some sheet metal operations. Reducing the tonnage requirements for such operations will sometimes make the presses capable of doing such operations. FEM simulation can be a reliable tool in predicting the amount of tonnage required for the metal stamping operation. An attempt is taken in this study to analyse the behaviour of the hole piercing operation in an automobile chain part using DEFORM 3D software. The main focus is on the prediction of tonnage requirement with different shear methods on the piercing. Simulations were conducted with flat, single sheared, double sheared, reverse double sheared, convex sheared and concave sheared punches and analyzed for variations in the press load. The phenomena of piercing are also observed through the simulation based on AISI 1060 steel component used for automobile chain as inner plate. Simulation results showed that the shear angles provided on piercing punches will reduce the punch load significantly.
Deterministic and Probabilistic Dietary Exposure Assessment to Deoxynivalenol in Spain and the Catalonia Region

Deoxynivalenol (DON) remains one of the most concerning mycotoxins produced by the Fusarium genus due to the wide occurrence in highly consumed cereal-based food and its associated toxicological effects. Previous studies conducted in Spain and other European countries suggested that some vulnerable groups such as children could be exceeding the tolerable daily intakes. Thus, the aim of this study was to conduct a comprehensive and updated dietary exposure assessment study in Spain, with a specific analysis in the region of Catalonia. Cereal-based food samples collected during 2019 were analysed using liquid chromatography coupled to tandem mass spectrometry for multi-mycotoxin detection including DON and its main metabolites and derivatives. Consumption data were gathered from the nation-wide food surveys ENALIA and ENALIA2 conducted in Spain, and a specific survey conducted in Catalonia. The data were combined using deterministic and semi-parametric probabilistic methods. The results showed that DON was widely present in cereal-based food highly consumed in Spain and the Catalonia region. Exposure to DON among the adult population was globally low; however, among infants aged 3–9 years, it resulted in the median of 192 ng/kg body weight/day and the 95th percentiles of 604 ng/kg body weight/day, that would exceed the most conservative safety threshold for infants. Bread and pasta were the main contributing foodstuffs to the global exposure to DON, even among infants; thus, those foods should be considered a priority for food control or to develop strategies to reduce the exposure. In any case, further toxicological and epidemiological studies are required in order to refine the safety thresholds accounting for the sensitivity of the infant population.
Araucariaceous fossil woods from the Upper Triassic Ischigualasto Formation (San Juan Province, Argentina): paleofloristic and paleoclimatic implications

Abstract. In this contribution, fossil woods from the Valle de La Luna Member of the Upper Triassic Ischigualasto Formation at Ischigualasto Provincial Park, San Juan Province, Argentina, are described. The specimens are preserved as silica permineralization in tuffs intercalated with carbonaceous mudstone beds interpreted as distal floodplain facies. The fossil woods were assigned to the new species Agathoxylon argentinum since their anatomy differs from the known Mesozoic Gondwanan species of the genus Agathoxylon. The combination of characters present in the new taxon indicates an affiliation with the conifer family Araucariaceae. Signals of fungal-mediated wood decay were observed, comparable to the activity of basidiomycetes. Spherical structures attached to the walls of the tracheids were recognized and are interpreted as holocarpic chytrid fungi. The growth rings were quantitatively analyzed. Low values of percentage diminution, percentage latewood, and Ring Markedness Index, and a mean percentage skew of +11.5, were obtained, suggesting that the new species was an evergreen gymnosperm. The stratigraphic distribution and taxonomic composition of the Ischigualasto Formation fossil-plant-bearing levels were studied. A vegetation change is recorded in the fossil level bearing Agathoxylon argentinum n. sp. , marked by the replacement of the corystosperm genera and a diminution of arboreal corystosperms. This floristic change, in addition to other evidence, indicates humid paleoclimatic conditions for the uppermost part of the Valle de La Luna Member of the Ischigualasto Formation.
Effectiveness and Safety of PD-1 Inhibitor Monotherapy for Elderly Patients with Advanced Non-Small Cell Lung Cancer: A Real-World Exploratory Study

Background Immunotherapy represented by PD-1 blockades had become the standard of care for advanced non-small cell lung cancer (NSCLC) gradually. Unfortunately, several PD-1 inhibitor-related studies excluded elderly patients with NSCLC over 75 years of age, resulting in relatively limited evidence regarding the efficacy and safety of PD-1 in elderly patients with NSCLC clinically. Objective This study aimed to identify the effectiveness and safety of PD-1 blockade monotherapy among elderly patients with advanced NSCLC. Methods Elderly patients with advanced NSCLC (≥65 years) who received PD-1 blockade monotherapy from September 2018 to December 2021 were screened retrospectively, and a total of 68 elderly patients with NSCLC were eligible for inclusion ultimately. The PD-1 blockades in the study were the available PD-1 monoclonal antibodies that had been approved for marketing in China, including camrelizumab, sintilimab, pembrolizumab, and nivolumab. The effectiveness and safety of the patients was collected retrospectively. Additionally, the correlation between prognosis and baseline characteristic subgroups was analyzed to identify the potential risk factors for progression-free survival (PFS). Results The median age of the 68 elderly patients with advanced NSCLC was 73 years (range: 65–82 years). Best overall response during PD-1 blockade administration suggested that no patients were found with complete response, partial response was found in 14 patients, stable disease was noted in 29 patients, and 25 patients had progressive disease, yielding an objective response rate (ORR) of 20.6% (95%CI: 11.7%–32.1%) and a disease control rate (DCR) of 63.2% (95%CI: 50.7%–74.6%). Furthermore, prognostic analysis exhibited that the median progression-free survival (PFS) of the 68 patients with advanced NSCLC was 3.5 months (95%CI: 2.4–4.6) and the median overall survival (OS) was 10.5 months (95%CI: 6.3–14.7). Additionally, a total of 48 patients were observed with the treatment-related adverse reaction (70.6%) of the 68 elderly patients with NSCLC, and the incidence of grade 3 or above adverse reactions was 16.2%. Specifically, the most common adverse reactions were fatigue, diarrhea, rash, and abnormal liver function with the incidence of 25.0%, 22.1%, 16.2%, and 14.7%, respectively. Exploratory analysis between PFS and baseline characteristic subgroups suggested that ECOG performance status and number of metastatic lesions might be independent factors for PFS. Conclusion PD-1 blockade monotherapy exhibited potential effectiveness and acceptable toxicity for elderly patients with NSCLC. ECOG performance status and number of metastatic lesions might be potential risk factors to predict the PFS of elderly patients with advanced NSCLC.
Robustness of Distributed Multi-User Beamforming: An Experimental Evaluation

In this paper, we study the robustness of distributed beamforming in the presence of hardware imperfections. In particular, we characterize the impact of carrier frequency offset (CFO) between distributed antennas on multi-user receive beamforming. We characterize the performance of distributed beamforming in the presence of CFO using a massive MIMO platform. Using datasets collected from the platform, we measure and compare the beamforming performance in the presence and absence of CFO. Further, we study the effect of variation in CFO among beamforming antennas on the performance through simulations. Interestingly, we observe that this drop in performance is higher as more distributed antennas are included in beamforming. Our results can be used to determine the optimal number of antennas in distributed beamforming systems.
Hepatoprotective Effect of Oyster Peptide on Alcohol-Induced Liver Disease in Mice

Alcohol-induced liver disease (ALD) has become one of the major global health problems, and the aim of this study was to investigate the characterization of the structure as well as the hepatoprotective effect and mechanism of oyster peptide (OP, MW < 3500 Da) on ALD in a mouse model. The results demonstrate that ethanol administration could increase the activities of aspartate aminotransferase (AST), alanine transaminase (ALT), γ-Glutamyl transferase (GGT), reactive oxygen species (ROS), malondialdehyde (MDA), and triglycerides (TG), as well as increase the interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) levels (p < 0.01), and reduce the activity of superoxide dismutase (SOD) and the concentration of glutathione (GSH). Those changes were significantly reversed by the application of different doses of OP. Furthermore, the mRNA expressions of nuclear factor elythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and quinone oxidoreductase1 (NQO1) were significantly up-regulated in OP groups, and the mRNA expressions of nuclear factor kappa-light chain enhancer of B cells (NF-κB), TNF-α, and IL-6 were markedly reduced in OP groups compared to that of the model group. Thus, OP had a significant protective effect on ALD through the enhancement of the in vivo antioxidant ability and the inhibition of the inflammatory response as possible mechanisms of action, which therefore suggests that OP might be useful as a natural source to protect the liver from alcohol damage.
‘No one can compete since no one dares to lend more cheaply!’: Turkey’s Ilbank and public water finance

ABSTRACT As a midsized public development bank in Turkey, Ilbank is crucial in financing water provision. It provides cheaper loans to municipalities and serves as an intermediary for accessing international funds. Being owned by municipalities and designed to serve them, Ilbank is unique in Turkey’s banking sector in terms of financing water provision. However, the potential of Ilbank to expand its role is limited due to recent revisions of its mandate, the attempts to divert its resources and its undemocratic structure. A reformed and democratized Ilbank could be a crucial player in building an integrated water and sanitation system management for Turkey.
“Family before Anyone Else”: A Qualitative Study on Family, Marginalization, and HIV among Hispanic or Latino/a/x Mexican Sexual Minority Males

This study explored the influence family relationships have on HIV-related factors among Hispanic or Latino/a/x Mexican sexual minority cisgender males in San Antonio, TX, US. A total of 15 young adults (7 people living with HIV; PLWH) ages 21–30 completed a semi-structured interview. Data were transcribed verbatim and analyzed using thematic analysis. The following themes emerged: (1) family support; (2) mother-son relationships; (3) father-son relationships; (4) sibling support; (5) family marginalization of sexual minorities; and (6) internalized homophobia. People who reported being HIV negative were more likely to have a prominent mother-son relationship, strong sense of family, supportive siblings, and family acceptance as a sexual minority. PLWH were more likely to report a weak sense of family, being raised in a maternal-led household, and less likely to have a relationship with their father and siblings. Marginalization among participants regardless of HIV status included exposure to religious rhetoric stigmatizing sexual minorities and fathers’ reinforcing Mexican traditional gender norms. In addition to encountering homophobia, PLWH were further marginalized by family members due to their HIV status. The findings suggest a need for greater attention to examining the impact of familial support of Hispanic or Latino/a/x Mexican sexual minority cisgender males as young adults with or at risk of HIV.
Comparing the Performance of Charlson and Elixhauser Comorbidity Indices to Predict In-Hospital Mortality Among a Chinese Population

Objective: Earlier comorbidity measures have been developed or validated using the North American population. This study aims to compare ﬁ ve Charlson or Elixhauser comorbidity indices to predict in-hospital mortality using a large electronic medical record database from Shanxi, China. Methods: Using the primary diagnosis code and surgery procedure codes, we identi ﬁ ed four hospitalized patient cohorts, hospitalized between 2013 and 2017, in Shanxi, China, as follows: congestive heart failure (CHF, n=41,577), chronic renal failure (CRF, n=40,419), diabetes (n=171,355), and percutaneous coronary intervention (PCI, n=39,097). We used logistic regression models and c -statistics to evaluate the in-hospital mortality predictive performance of two multiple comorbidity indicator variables developed by Charlson in 1987 and Elixhauser in 1998 and three single numeric scores by Quan in 2011, van Walraven in 2009, and Moore 2017. Results: Elixhauser comorbidity indicator variables had consistently higher c -statistics (0.824, 0.843, 0.904, 0.853) than all other four comorbidity measures, across all four disease cohorts. Moore ’ s comorbidity score outperformed the other two score systems in CHF, CRF, and diabetes cohorts ( c -statistics: 0.776, 0.832, 0.869), while van Walraven ’ s score outperformed all others among PCI patients ( c -statistics: 0.827). Conclusion: Elixhauser comorbidity indicator variables are recommended, when applied to large Chinese electronic medical record databases, while Moore ’ s score system is appropriate for relatively small databases.
Use mix of Chitosan-Graphene oxide nanoparticle to reduce copper from aqueous solution

The current study aims to evaluate the adsorption of lead element in aqueous solution by using a nano-material consisting of a mixture of reduced graphene oxide and nano-chitosan, which was prepared in a 1:1 ratio. And an X-ray diffraction device for studying the crystal structure of nanomaterials. The results showed that the percentage of element removal increases with increasing concentration of the nanomaterial and under constant conditions of temperature and pH, and the percentage of removal was studied in three time replicates (24,48,96 hours).
Study on Intelligent Online Piano Teaching System Based on Deep Learning Recurrent Neural Network Model

This study has been conducted to solve the problem of repetitive piano lessons and to bring a personalized experience for each piano learner. The application of deep learning (DL) technology for children’s piano teaching has a positive effect on their interest in the subject and improves the teaching quality. Music instruments were identified in the system using an instrument recognition model that was developed using deep learning techniques. It was also utilized to help children learn to play the piano by giving them direction and boosting their excitement for it. The proposed model’s ability to recognize and acquire features has been improved. The recurrent neural network (RNN) demonstrated instrument recognition accuracy of 96.4%, and the model’s recognition error rate decreased and stabilized as the number of iterations increased. The proposed RNN for musical instruments recognizes instruments by using DL to accurately identify musical properties.