Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of a Cognitive Behavioral Intervention for the Prevention of Depression in Nonprofessional Caregivers Administered through a Smartphone App: A Randomized Controlled Trial

Due to the limited availability of in-person interventions for caregivers, the development of effective programs that use new technologies to prevent depression is needed. The goal of this research was to assess the efficacy of a cognitive behavioral intervention for the prevention of depression, administered to nonprofessional caregivers through a smartphone application (app). One hundred and seventy-five caregivers were randomly assigned to either an app-based cognitive behavioral intervention (CBIA), the CBIA intervention plus a telephone conference call (CBIA + CC), or an attention control group (ACG). At post-intervention, the incidence of depression was lower in the CBIA and CBIA + CC compared to the ACG (1.7% and 0.0% vs. 7.9%, respectively). The absolute risk, relative risk, and number needed to treat compared to the ACG were 6.2%, 21.6%, and 16 for the CBIA, whilst they were 8%, 0.0%, and 13 for the CBIA + CC. Depressive symptomatology was significantly lower in the CBIA and CBIA + CC compared to the ACG (d = 0.84, Cliff’s δ = 0.49; d = 1.56, Cliff’s δ = 0.72), as well as in the CBIA + CC compared to the CBIA (d = 0.72, Cliff’s δ = 0.44). The prevention of depression was more likely in participants who received the CBIA, and adding the conference call in the CBIA + CC group improved the likelihood of this.
Environmental Factors that are at Risk of Heat Stress Exposure to Fishermen in Indonesia

Introduction: Workers face pressure that comes from the work environment, one of which is heat pressure. Exposure to heat, workload, rehydration, and rest period are several factors that can cause heat stress to workers. People who are uncovered to heat are much more likely to experience heat stress. Related to this, current research was carried out aiming to analyze environmental factors that are at risk of heat stress exposure to fishermen in Indonesia. Methods: This study was conducted through a cross sectional design in the coastal regions in Surabaya. Accidental sampling technique was applied, obtaining 42 respondents. In this case, the variables included are humidity, temperature, access to clean water, risk of heat stress, and dehydration, while the data analysis techniques used are the logistic regression and pearson correlation. Results: The results showed that the significant environmental factor is access to clean water, with a value of 0.009 so that the p-value is less than 0.05. Furthermore, the relationship between heat stress and dehydration is 27.1%. Conclusion: Therefore, this study concludes that only access to clean water is significantly related to the risk of heat stress. In addition, the relationship between heat stress and the incidence of dehydration is weak.
Community diversity and the other-race effect in infancy

The other-race effect (ORE) is characterized by processing advantages for faces of one's own race over faces of another race and is observed at ~9 months of age. Environmental exposure to other races has an impact on the development of the ORE. In the current study, we examined the effects of community racial diversity on the ORE in 9- to 12-month-olds from across the United States. We hypothesized that community racial diversity would influence the amount of experience that infants have with individuals of other races and be an important factor in predicting the ORE across broad regions of the United States. We predicted that infants from more diverse communities would demonstrate successful processing of own- and other-race faces, while infants from less diverse communities would demonstrate successful processing of own-race but not other-race faces. This would indicate that the ORE is exhibited more strongly in infants from less diverse communities than in infants from more diverse communities. Participants completed familiarization and visual paired comparison (VPC) trials with own- and other-race faces in an online study. Our results showed that although the ORE was present, the effect was driven by community members who were the racial majority. Recognition biases were not observed in community racial or ethnic minority participants, potentially due to increased exposure to racial out-group members, which mitigated the development of the ORE in this subset of participants. This study has far-reaching implications in the study of infant face perception, child development, and social justice, as the ORE develops at a young age, and may lead to a complex pattern of racial biases contributing to systemic barriers in society.
ERBB2-Mutant Gastrointestinal Tumors Represent Heterogeneous Molecular Biology, Particularly in Microsatellite Instability, Tumor Mutation Burden, and Co-Mutated Genes: An In Silico Study

During recent years, activating mutations in ERBB2 have been reported in solid tumors of various organs, and clinical trials targeting ERBB2-mutant tumors have been conducted. However, no effective treatment has been established for gastrointestinal tumors targeting ERBB2 mutations. ERBB2-mutant tumors have a higher tumor mutation burden (TMB) and microsatellite instability (MSI) than ERBB2 non-mutant tumors, but not all ERBB2-mutant tumors are TMB- and MSI-high. Thus, a more detailed classification of ERBB2-mutant tumors based on the underlying molecular mechanisms is required. Herein, we classified ERBB2 mutations into three groups—group 1: both ERBB2 mutations and amplifications; group 2: ERBB2 mutations annotated as putative driver mutations but without amplifications; group 3: ERBB2 mutations annotated as non-driver mutations (passenger mutations or unknown significance) and those that were not amplified in gastrointestinal tumors. Esophageal adenocarcinoma, gastric cancer, and colorectal cancer presented significantly higher MSI and TMB in the ERBB2-mutant group than in the ERBB2-wild-type group. The proportions of TMB- and MSI-high tumors and frequency of co-mutated downstream genes differed among the groups. We identified TMB- and MSI-high groups; this classification is considered important for guiding the selection of drugs for ERBB2-mutant tumors with downstream genetic mutations.
INFLUENCE OF TILLAGE PRACTICES ON YIELD COMPONENTS AND ECONOMIC ANALYSIS OF MAIZE

An investigation under field condition was carried out to explore the effect of different tillage practices on yield components and economic analysis of maize crop at experimental site of Sindh Agriculture University Tandojam during two growing seasons (2009 and 2010). The tillage treatments include: T1 (conventional tillage), T2 (reduced tillage) and T3 (no tillage). Maximum plant height, cob weight, 1000-grain weight and yield were found under T1 treatment, followed by T2 and T3 treatments during both growing seasons (2009 and 2010). Similarly, the maximum net benefit was also achieved under conventional tillage system, followed by reduced and no tillage treatments during 2009 and 2010; while the maximum marginal rate of return was observed under reduced tillage, followed by conventional tillage system during 2009 and 2010. Therefore, conventional tillage system is recommended to achieve higher maize yield and net benefits.
Quantification of groundwater storage heterogeneity in weathered / fractured basement 1 rock aquifers using electrical resistivity tomography : sensitivity and uncertainty 2 associated with petrophysical modelling 3

Quantifying groundwater storage in weathered/fractured basement rock aquifers can be 12 challenging owing to both their high degree of heterogeneity and their overall low storage capacity. 13 Therefore, in these aquifers, the use of direct borehole hydraulic data is usually insufficient. Here we 14 assessed the popular method of electrical resistivity tomography (ERT), combined with borehole data 15 and including associated uncertainties, to resolve the spatial variability of groundwater storage 16 properties at high resolution within a fractured mica schist aquifer in Ireland. Porosity distributions 17 across both the saturated and unsaturated zones were calculated from two-dimensional (2D) ERT 18 resistivities using two standard petrophysical models, Archie and Waxman & Smits (WS), the latter 19 accounting for the influence of clay minerals on resistivity data. Our results demonstrated the 20 importance of the hydrogeological conceptual constraints provided by ERT when parametrizing the 21 2D petrophysical models from borehole point data. They also confirmed the importance of accounting 22 for clay minerals (the products of bedrock weathering processes) in the WS model, whereas 23 predictions from Archie’s model produced unrealistically high porosity values of over an order of 24 magnitude higher than the WS model. The WS model predicted porosities decreasing exponentially 25
Late Wisconsin glaciation of Tasmania

During the Late Wisconsin, icecap and outlet glacier systems developed on the West Coast Range and on the Central Plateau of Tasmania. Local cirque and valley glaciers occurred in many other mountain areas of southwestern Tasmania. Criteria are outlined that enable Late Wisconsin and older glacial landforms and deposits to be distinguished. Radiocarbon dates show Late Wisconsin ice developed after 26-25 ka BP, attained its maximum extent c. 19 ka BP, and disappeared from the highest cirques before 10 ka BP. Important Late Wisconsin age glacial landforms and deposits of the West Coast Range, north-central and south-central Tasmania are described. Late Wisconsin ice was less extensive than ice formed during middle and earlier Pleistocene glaciations. Late Wisconsin snowline altitudes, glaciological conditions and palaeoclimatic conditions are outlined.
Association of IL-10-1082G>A, -819C>T and -592C>A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis

Summary Studies evaluating the association of Interleukin 10 (IL-10) polymorphisms with risk of pediatric asthma found inconsistent data. Here, we performed a meta-analysis to get a precise estimation of the associations. Relevant studies identified in the PubMed, Scopus, CNKI databases were used to perform a meta-analysis. A total of 23 case-control studies including nine studies with 1298 cases and 1079 controls on IL-10-1082G>A, four studies with 622 cases and 603 controls on -819C>T and ten studies with 1480 case and 1462 controls on -592C>A were selected. Overall, there was no significant association between IL-10 polymorphisms with pediatric asthma risk in global population. When stratified by ethnicity, there was a significant association of IL-10-1082G>A with pediatric asthma in Asians and Chinese. This meta-analysis result revealed that IL-10-1082G>A, -819C>T and -592C>A polymorphisms were not associated with pediatric asthma risk in the global population.
Identification of Antioxidative Hydrolyzable Tannins in Water Chestnut

Despite the various biological activities exhibited by water chestnut (the fruit of the Trapa genus), the phenolic compounds present in its extract require comprehensive characterization. Accordingly, we analyzed a 80% methanol extract of commercially available water chestnut and identified a new hydrolyzable tannin dimer termed trapadin A. Additionally, 22 known compounds, including 10 hydrolyzable tannin monomers and 2 dimers, were also detected in the extract. Spectroscopic and chemical methods were used to elucidate the structure of trapadin A, revealing it to be a hydrolyzable tannin dimer formed from units of tellimagrandin II and 1,2,3,6-tetra-O-galloyl-β-d-glucose. Moreover, the 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity assay used to determine the half-maximal effective concentration values for the 23 compounds isolated from water chestnut indicated significant radical scavenging activity associated with hydrolyzable tannins. Notably, trapadin A, the new hydrolyzable tannin dimer, exhibited the highest activity value among the tested compounds.
IMPLEMENTASI PENDEKATAN REALISTICS MATHEMATICS EDUCATION (RME) UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KREATIF MATEMATIS SISWA

Penelitian ini didasarkan pada permasalahan masih rendahnya kemampuan berpikir kreatif matematis siswa. Kemampuan berpikir kreatif matematis siswa sangat penting untuk dikuasai, terutama untuk mengembangkan konsep-konsep matematika secara fluency, flexibility, originality dan elaboration yang dapat digunakan dalam kehidupan sehari-hari. Berpikir kreatif matematis akhir-akhir ini menjadi isu penting untuk dikembangkan dalam kajian pembelajaran matematika. Namun berpikir kreatif matematis belum menjadi tujuan utama dalam pelaksanaan pembelajaran yang dilakukan. Tujuan penelitian ini adalah untuk mengetahui apakah terdapat perbedaan peningkatan kemampuan berpikir kreatif matematis siswa yang memperoleh pembelajaran dengan pendekatan RME dengan siswa yang memperoleh pembelajaran dengan metode pembelajaran konvensional. Metode penelitian yang digunakan dalam penelitian ini adalah eksperimen semu dengan desain non-equivalent pretest-posttest control group design. Populasi dalam penelitian ini adalah siswa kelas VIII SMP Negeri 2 Majenang yang terdiri dari sepuluh kelas. Adapun sampelnya dipilih dengan teknik purposive sampling dan yang terpilih yaitu kelas VIII D sebanyak 32 siswa sebagai kelas eksperimen dan kelas VIII E sebanyak 31 siswa sebagai kelas kontrol. Kelas eksperimen menggunakan pendekatan Realistics Mathematics Education (RME) dan kelas kontrol menggunakan metode pembelajaran konvensional. Instrumen dalam penelitian ini adalah tes kemampuan berpikir kreatif matematis. Materi yang digunakan dalam penelitian ini adalah statistika. Hasil dari hipotesis penelitian diterima. Tidak menutup kemungkinan peningkatan kemampuan berpikir kreatif matematis siswa dipicu oleh pembelajaran dengan pendekatan RME yang dalam pelaksanaan pembelajarannya selalu menitikberatkan pada matematika dalam dunia nyata yang dekat dengan kehidupan siswa. Kata Kunci : Kemampuan Berpikir Kreatif Matematis; Pendekatan Realistics Mathematics Education (RME)
Risk Characterization of Treatment Histories and Comorbidities Regarding Tuberculosis Treatment Status in West Sumatra Province 2020-2021

Background: Tuberculosis (TB) is the leading cause of death among bacterial infectious diseases worldwide, and Indonesia is the second country with the highest TB burden.Objective: The treatment history and comorbidities of TB disease play a significant role in determining the appropriateness of therapy and the duration of treatment for patients. The objective is to identify the factors that influence the incidence of first molar caries.Methods: This study employs an analytic case-control design with a retrospective cohort methodology. 161 RO TB patients and 161 SO TB patients comprised the total sample size. Statistical analysis of this investigation utilizing R and R Studio.Result: In this study, there was a correlation between gender (p-value 0.006 and odds ratio 1.89), contact investigation (p-value 0.001 and odds ratio 0.23), new TB (p-value 0.001 and odds ratio 0.05), TB recurrence (p-value 0.001 and odds ratio 19.0), TB failed treatment (p-value 0.007 and odds ratio 16.4), and pH-saliva (p-value 0.0001 and odds ratio 21.250). In contrast, risk factors such as absenteeism, diabetes, and HIV were not associated with TB treatment status (p-value 0.05). Age, investigation of contact, and TB recurrence were the predominant factors associated with TB treatment status, as determined by multivariate analysis.Conclusions: Several factors, including gender and treatment history (new TB, Relapsed TB, Failed TB), influence the status of TB treatment in West Sumatra Province. These are important factors that must be considered and asked by TB officers at health facilities before the patient undergoes an examination of suspected samples and information to provide appropriate medical therapy to TB patients in health facilities.
Supplementation with Vitamin D3 Protects against Mitochondrial Dysfunction and Loss of BDNF-Mediated Akt Activity in the Hippocampus during Long-Term Dexamethasone Treatment in Rats

Dexamethasone (DEXA) is a commonly used steroid drug with immunosuppressive and analgesic properties. Unfortunately, long-term exposure to DEXA severely impairs brain function. This study aimed to investigate the effects of vitamin D3 supplementation during chronic DEXA treatment on neurogenesis, mitochondrial energy metabolism, protein levels involved in the BDNF-mediated Akt activity, and specific receptors in the hippocampus. We found reduced serum concentrations of 25-hydroxyvitamin D3 (25(OH)D3), downregulated proBDNF and pAkt, dysregulated glucocorticosteroid and mineralocorticoid receptors, impaired mitochondrial biogenesis, and dysfunctional mitochondria energy metabolism in the DEXA-treated group. In contrast, supplementation with vitamin D3 restored the 25(OH)D3 concentration to a value close to that of the control group. There was an elevation in neurotrophic factor protein level, along with augmented activity of pAkt and increased citrate synthase activity in the hippocampus after vitamin D3 administration in long-term DEXA-treated rats. Our findings demonstrate that vitamin D3 supplementation plays a protective role in the hippocampus and partially mitigates the deleterious effects of long-term DEXA administration. The association between serum 25(OH)D3 concentration and BDNF level in the hippocampus indicates the importance of applying vitamin D3 supplementation to prevent and treat pathological conditions.
Fifty Years of Animal Toxin Research at the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS

This review covers briefly the work carried out at our institute (IBCh), in many cases in collaboration with other Russian and foreign laboratories, for the last 50 years. It discusses the discoveries and studies of various animal toxins, including protein and peptide neurotoxins acting on the nicotinic acetylcholine receptors (nAChRs) and on other ion channels. Among the achievements are the determination of the primary structures of the α-bungarotoxin-like three-finger toxins (TFTs), covalently bound dimeric TFTs, glycosylated cytotoxin, inhibitory cystine knot toxins (ICK), modular ICKs, and such giant molecules as latrotoxins and peptide neurotoxins from the snake, as well as from other animal venoms. For a number of toxins, spatial structures were determined, mostly by 1H-NMR spectroscopy. Using this method in combination with molecular modeling, the molecular mechanisms of the interactions of several toxins with lipid membranes were established. In more detail are presented the results of recent years, among which are the discovery of α-bungarotoxin analogs distinguishing the two binding sites in the muscle-type nAChR, long-chain α-neurotoxins interacting with α9α10 nAChRs and with GABA-A receptors, and the strong antiviral effects of dimeric phospholipases A2. A summary of the toxins obtained from arthropod venoms includes only highly cited works describing the molecules’ success story, which is associated with IBCh. In marine animals, versatile toxins in terms of structure and molecular targets were discovered, and careful work on α-conotoxins differing in specificity for individual nAChR subtypes gave information about their binding sites.
Loop Current Frontal Eddies Based on Satellite Remote-Sensing and Drifter Data

This study examines ocean surface features and near surface circulation in the Gulf of Mexico. It targets remote sensing methods to improve the surveillance of said features. The Loop Current and the eddies associated with it are the most vigorous ocean circulation features in the Gulf of Mexico. The more specific goal of this research was to apply remote sensing techniques to better understand the basic characteristics of Loop Current Frontal Eddy cyclones - especially where they begin, how they progress as they travel around the Loop Current, frequency of occurrence, and how they impact circulation throughout the region where gas and oil operations are located.
Ten-Year Results of Tree Shelters on Survival and Growth of Planted Hardwoods

The perjformance of planted northern red oak (Quercus rubra L.), black walnut (Juglans nigra L.), and green ash (Fraxinus pennsylvanica Marsh.), with and without tree shelters, was evaluated 10 yr after planting. Northern red oak was planted in three harvestedforest openings, and black walnut and green ash were planted in a cultivatedfield. Survival of northern red oak with tree shelters was significantly (P < 0.05) higher than northern red oak without shelters only for year 3. Survival diflerences between tree shelter treatments for black walnut and green ash were not significant. However, overall survival of green ash declined rapidly after year 5. Trees began to exit the 120-cm-tall shelters after 2 yr, but not in large numbers until the fourth year. Sheltered oaks were significantly taller than unsheltered oaks at year 10, and sheltered oaks had more height growth than unsheltered oaks at year 5, but not at year 10. Except for year 1, neither height nor height growth for black walnut was significantly diflerent between tree shelter treatments. Green ash was taller and had more height growth with shelters than without shelters in year 1, but had more height growth without shelters than with shelters in year 5. Diameter growth at breast height did not difler between treatments for any of the three species. The greater height of sheltered northern red oaks compared to unsheltered northern red oaks could increase the opportunity of sheltered oaks to achieve dominant and codominant positions in the developing stands. North. J. Appl. For. 20(3): 104-1 08.
Social competence and academic achievement in immigrant adolescents in Portugal

The aim of the present study was to examine the relation between social skills, academic achievement and a range of family characteristics in a sample of 98 school adolescent immigrants in the region of Algarve (Portugal). The Self-report Form of the Social Skills Rating System was used and data was gathered about the students’ academic achievement and family related variables such as: parental employment and qualifications, number of years in the coun try and family structure. The results show some interesting group differences between first- and second-generation adolescent immigrants in their perceived social skills in terms of Self-control and Cooperation, with the second generation group reporting significantly lower levels on these two subscales. Also, there was for all the adolescents a signifi cant positive correlation between academic results and their reported levels of Assertion and Self-control. The results are discussed in relation to school-based social skills intervention.