Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification and virulence screening of fungal and bacterial entomophathogens of the edible long-horned grasshopper Ruspolia differens (Orthoptera: Tettigoniidae) from Uganda

Natural enemies are major challenges in laboratory rearing of grasshoppers, but the identity and virulence of these towards the edible long-horned grasshopper Ruspolia differens (Serville) is scarcely known. In this study, fungi and bacteria were isolated from R. differens collected from Mbarara, Masaka, Hoima, Kampala and Kabale districts in Uganda in 2018, cultured on standard microbial media, identified using molecular techniques and screened for virulence against the insect in laboratory bioassays. Fourteen and nine species of fungi and bacteria were isolated from R. differens, respectively, with the number of isolates varying based on collection site. The most prevalent entomopathogenic fungal species were Aspergillus flavus Link (27.3%), Fusarium equiseti (Corda) (24.2%), Mucor fragilis Fresen (12.1%), Clonostachys rosea (Link) (6.0%) and Aspergillus tamarii Kita (6.0%); whereas the most prevalent bacterial isolates were Serratia marcescens Bizio (38.1%), Bacillus thuringiensis (Berliner) (14.3%) and Enterobacter cloacae (Jordan) (14.3%). Nine of the fungal species namely Clavispora lusitaniae Rodrigues de Miranda, Lichtheimia corymbifera (Cohn), Trichoderma koningii Oudem, F. equiseti, M. fragilis, Aspergillus niger van Tieghem, Epicoccum sorghinum (Saccardo), C. rosea, Penicillium commune Charles Thom; and five bacterial species (Proteus penneri Hickman, S. marcescens, B. thuringiensis, Staphylococcus sciuri Kloos and Enterococcus faecalis (Andrewes and Horder)) were ~5–7-fold and ~4–5-fold, more lethal to third instars of R. differens than untreated controls, respectively. This study is the first to report C. lusitaniae, Exserohilum mcginnis Padhye and Ajello, E. sorghinum, P. penneri and E. cloacae as insect pathogens. The results suggest a need to quarantine field collected R. differens before introducing them into the insectary, as well as performing antimicrobial practices during rearing of the insect to prevent entomopathogen-based mortality.
Interpreting growth hormone and IGF-I results using modern assays and reference ranges for the monitoring of treatment effectiveness in acromegaly

Standard treatment for acromegaly focuses on the achievement of target absolute levels of growth hormone (GH) and insulin-like growth factor (IGF-I). The appropriateness of these targets when measured using modern assay methods is not well defined. This paper reviews biochemical status assessed using methods available at the time and associated clinical outcomes. GH measurements were shown to provide an indication of changes in tumor size, and failure of GH suppression after glucose stimulation is associated with tumor recurrence. IGF-I levels were more closely associated with changes in symptoms and signs. Reduced GH and IGF-I concentrations were shown to be associated with increased longevity, although the degree of increase has only been analyzed for GH. Lowering of GH and IGF-I has consistently been associated with improved outcomes; however, absolute levels reported in previous studies were based on results from methods and reference ranges that are now obsolete. Applying previously described absolute thresholds as targets (e.g. “normal” IGF-I level) when using current methods is best applied to those with active acromegaly symptoms who could benefit from further lowering of biochemical markers. In asymptomatic individuals with mild IGF-I or GH elevations, targeting biochemical “normalization” would result in the need for combination pharmacotherapy in many patients without proven benefit. Measurement of both GH and IGF-I remains an essential component of diagnosis and monitoring the effectiveness of treatment in acromegaly; however, treatment goals based only on previously identified absolute thresholds are not appropriate without taking into account the assay and reference ranges being employed. Treatment goals should be individualized considering biochemical improvement from an untreated baseline, symptoms of disease, risks, burdens and costs of complex treatment regimens, comorbidities, and quality of life.
Raised Shoreline Phenomena and Postglacial Emergence in South-Central Newfoundland

Two types of raised marine shoreline features occur in the Burin-Hermitage area of southern Newfoundland marine benches cut in bedrock, and terraces and beaches developed in unconsolidated materials. Most of the benches are older than Late Wisconsinan, and a horizontal rock shoreline at 4.5 ± 1.5 m, which occurs throughout the region, was probably formed in the last interglacial period. Raised deltas and coastal outwash deposits graded to former sea level positions, which define the Late Wisconsinan marine limit across the northern part of the study area, are correlated with terraces and raised beaches further south on the Burin Peninsula. The elevations of these features are used to define the regional pattern of postglacial emergence. More than 30 m of emergence has occurred in the northwest, but the extreme southern part of the region is undergoing submergence.
Southern Laurentide ice-sheet retreat synchronous with rising boreal summer insolation

Establishing the precise timing for the onset of ice-sheet retreat at the end of the Last Glacial Maximum (LGM) is critical for delineating mechanisms that drive deglaciations. Uncertainties in the timing of ice-margin retreat and global ice-volume change allow a variety of plausible deglaciation triggers. Using boulder 10 Be surface exposure ages, we date initial southern Laurentide ice-sheet (LIS) retreat from LGM moraines in Wisconsin (USA) to 23.0 ± 0.6 ka, coincident with retreat elsewhere along the southern LIS and synchronous with the initial rise in boreal summer insolation 24–23 ka. We show with climate-surface mass balance simulations that this small increase in boreal summer insolation alone is potentially sufficient to drive enhanced southern LIS surface ablation. We also date increased southern LIS retreat after ca. 20.5 ka likely driven by an acceleration in rising isolation. This near-instantaneous southern LIS response to boreal summer insolation before any rise in atmospheric CO 2 supports the Milankovic hypothesis of orbital forcing of deglaciations.
Biological Activities of Citrus aurantium Leaf Extract by Optimized Ultrasound-Assisted Extraction

Several studies have explored the biological activities of Citrus aurantium flowers, fruits, and seeds, but the bioactivity of C. aurantium leaves, which are treated as waste, remains unclear. Thus, this study developed a pilot-scale ultrasonic-assisted extraction process using the Box–Behnken design (BBD) for the optimized extraction of active compounds from C. aurantium leaves, and their antityrosinase, antioxidant, antiaging, and antimicrobial activities were evaluated. Under optimal conditions in a 150× scaleup configuration (a 30 L ultrasonic machine) of a pilot plant, the total phenolic content was 69.09 mg gallic acid equivalent/g dry weight, which was slightly lower (3.17%) than the theoretical value. The half maximal inhibitory concentration of C. aurantium leaf extract (CALE) for 2,2-diphenyl-1-picrylhydrazyl–scavenging, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)–scavenging, antityrosinase, anticollagenase, antielastase and anti-matrix metalloprotein-1 activities were 123.5, 58.5, 181.3, 196.4, 216.3, and 326.4 mg/L, respectively. Moreover, the minimal inhibitory concentrations for bacteria and fungi were 150–350 and 500 mg/L, respectively. In total, 17 active compounds were detected in CALE—with linalool, linalyl acetate, limonene, and α-terpineol having the highest concentrations. Finally, the overall transdermal absorption and permeation efficiency of CALE was 95.9%. In conclusion, our CALE demonstrated potential whitening, antioxidant, antiaging, and antimicrobial activities; it was also nontoxic and easily absorbed into the skin as well as inexpensive to produce. Therefore, it has potential applications in various industries.
A New Iguanodontian Dinosaur from the Lower Cretaceous Khok Kruat Formation, Nakhon Ratchasima in Northeastern Thailand

Here we report a new iguanodontian dentary found from the Lower Cretaceous Khok Kruat Formation, Nakhon Ratchasima, northeast Thailand. A unique character, which is an elongated and flat shape of the dentary ramus, makes it possible to assign the specimen to the new genus of non‐hadrosaurid iguanodontian, Ratchasimasaurus suranareae gen. et sp. nov. R. suranareae shows both primitive and derived characters, such as a caudally inclined coronoid process and alveolar trough with a primitive crown impression, and a derived buccal shelf between tooth row and coronoid process. The discovery of a new iguanodontian from the Indochina Terrene, considering that the previously reported “Probactrosaurus‐like” iguanodontian, points out a great diversity of this group in the late Early Cretaceous in Thailand, and corresponds to the Asian iguanodontian diversity at that time.
A Case Report of Plasmacytoma in a 28-Year-Old Patient: Bridging the Age Gap in a Rare Presentation

Plasmacytoma, an uncommon malignancy originating from plasma cells, predominantly manifests in the elderly demographic. However, its incidence among young adults remains infrequent. Herein, we present a case involving a 28-year-old young adult diagnosed with solitary bone plasmacytoma. The patient presented with acute exacerbation of chronic lower back pain of two years, which, upon hospitalization, was attributed to a lumbar spine compression fracture. Comprehensive blood analysis, imaging studies, and pathology assessments suggested the likelihood of solitary plasmacytoma, devoid of indicators characteristic of multiple myeloma (MM). The patient was given symptomatic treatment and underwent surgical spine decompression, followed by the commencement of radiation therapy to address the malignancy. Subsequent to radiotherapeutic intervention, a noteworthy amelioration in pain and overall condition was observed. This case report assumes importance due to the insight it provides into the natural progression of solitary plasmacytoma. Patients with pathological fractures warrant thorough assessment for solitary plasmacytoma, necessitating vigilant monitoring for its potential evolution into MM. This case serves as a pertinent illustration of the need to expand our existing knowledge of solitary bone plasmacytoma, moving beyond the conventional notion that it predominantly afflicts the elderly population.
The Effects of Individual Differences in Working Memory on Trust Recovery

While trust repair is an active area of inquiry (i.e., systems that proactively repair users’ trust in itself, De Visser, Pak, and Shaw 2018), most technology does not have the ability to initiate trust repair. Thus, it is crucial to examine how unaided trust recovery occurs and the factors that could influence it. Prior research has highlighted the potential importance of individual difference factors such as working memory capacity (e.g., Rovira, Pak, McLaughlin, 2017). Previous research also suggests operators’ trust on automation recovers naturally without trust repair strategies (e.g., Lee and Moray, 1992; Mishler and Chen, 2023). However, the specific dynamics of unaided trust recovery and how they are influenced by individual differences are unknown. There are theoretical and practical reasons why this topic is important. Theoretically, it is important to know why some people show trust recovery (i.e., trust recovery naturally, over time), but not others, as such information can inform theories of human-machine trust. Practically, a lot of technologies do not have a trust repairing system to rebuild users’ trust after errors occur; information gained in this study may have direct implications for redesigning systems to aid trust recovery (without using trust repair). The current study has two goals; the first is to understand how trust recovers naturally (unaided). The second goal is to specifically examine how working memory is related to the process of unaided trust recovery. This study will use a computer-based automation task to examine participants’ trust level at three different time points (i.e., before, during, and after automation failures). A final exploratory role of this study will be to examine the role of attention control on trust dynamics. The current study will shed light on individual differences in unaided trust recovery and potential causes.
Northwest Africa 4797: A strongly shocked ultramafic poikilitic shergottite related to compositionally intermediate Martian meteorites

Abstract– Northwest Africa (NWA) 4797 is an ultramafic Martian meteorite composed of olivine (40.3 vol%), pigeonite (22.2%), augite (11.9%), plagioclase (9.1%), vesicles (1.6%), and a shock vein (10.3%). Minor phases include chromite (3.4%), merrillite (0.8%), and magmatic inclusions (0.4%). Olivine and pyroxene compositions range from Fo66–72,En58–74Fs19–28Wo6–15, and En46–60Fs14–22Wo34–40, respectively. The rock is texturally similar to “lherzolitic” shergottites. The oxygen fugacity was QFM−2.9 near the liquidus, increasing to QFM−1.7 as crystallization proceeded. Shock effects in olivine and pyroxene include strong mosaicism, grain boundary melting, local recrystallization, and pervasive fracturing. Shock heating has completely melted and vesiculated igneous plagioclase, which upon cooling has quench‐crystallized plagioclase microlites in glass. A mm‐size shock melt vein transects the rock, containing phosphoran olivine (Fo69–79), pyroxene (En44–51Fs14–18Wo30–42), and chromite in a groundmass of alkali‐rich glass containing iron sulfide spheres. Trace element analysis reveals that (1) REE in plagioclase and the shock melt vein mimics the whole rock pattern; and (2) the reconstructed NWA 4797 whole rock is slightly enriched in LREE relative to other intermediate ultramafic shergottites, attributable to local mobilization of melt by shock. The shock melt vein represents bulk melting of NWA 4797 injected during pressure release. Calculated oxygen fugacity for NWA 4797 indicates that oxygen fugacity is decoupled from incompatible element concentrations. This is attributed to subsolidus re‐equilibration. We propose an alternative nomenclature for “lherzolitic” shergottites that removes genetic connotations. NWA 4797 is classified as an ultramafic poikilitic shergottite with intermediate trace element characteristics.
GENDER, RACE, AND COMMUTING AMONG SERVICE SECTOR WORKERS∗

The generality that women work closer to home and have shorter commuting times than men needs to be assessed for racial groups. Statistical analysis of commuting times for a large sample of service workers in the New York metropolitan area shows that black and hispanic women commute as far as their male counterparts and their commuting times far exceed those of white men and women. Workplace factors, such as income, occupation, and job accessibility, are important in explaining these findings.
Exosome Liberation by Human Neutrophils under L-Amino Acid Oxidase of Calloselasma rhodostoma Venom Action

L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation of platelet aggregation, hemorrhage, and neutrophil activation. Human neutrophils respond to LAAO by enhancing chemotaxis, and phagocytosis, and releasing reactive oxygen species (ROS) and pro-inflammatory mediators. Exosomes cellular nanovesicles play vital roles in intercellular communication, including immune responses. This study investigates the impact of Calloselasma rhodostoma snake venom-derived LAAO (Cr-LAAO) on human neutrophil exosome release, including activation patterns, exosome formation, and content. Neutrophils isolated from healthy donors were stimulated with Cr-LAAO (100 μg/mL) for 3 h, followed by exosome isolation and analysis. Results show that Cr-LAAO induces the release of exosomes with distinct protein content compared to the negative control. Proteomic analysis reveals proteins related to the regulation of immune responses and blood coagulation. This study uncovers Cr-LAAO’s ability to activate human neutrophils, leading to exosome release and facilitating intercellular communication, offering insights into potential therapeutic approaches for inflammatory and immunological disorders.
Risk Perceptions After a Coal Waste Impoundment Failure: A Survey Assessment

In mid October of 2000, a rupture occurred at the bottom of a coal waste reservoir owned by Martin County Coal Corporation (MCCC-Massey). Impounded slurry and sludge materials from the reservoir traveled through underground mine works and burst through two mine portals on opposite sides of the mountain releasing more than 300 million gallons of coal waste into creeks and waterways of Martin County, KY. This paper examines people’s reactions to the Martin County coal waste disaster by examining levels of reported concern and perceptions of risk across the impacted community of Martin County in comparison to similar coal mining communities in the same watershed as well as elsewhere in Kentucky and West Virginia. Door-to-door, drop-off/ pick-up methods were used to survey people’s perceptions. As predicted, findings show a significant difference in public opinion over the risks associated with coal waste impoundments between the impacted county in comparison to other counties. The other robust predictors of perceived risks were quality of life and trust measures. Other factors found to be significant in some previous studies of risk perceptions, such as home ownership and occupation could also account for some differences in risk perceptions within and across counties. Overall, we conclude that our survey findings on trust are consistent with others who have theorized
Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice

This study aimed to explore the effects and mechanisms of maternal gestational diabetes mellitus (GDM) and selenium (Se) deficiency on the growth and glucose metabolism of offspring. Female C57BL/6J mice were divided into four groups as follows: a control group, a GDM group, a Se deficiency group, and a GDM with Se deficiency group. GDM animal models were established via S961. Pregnant mice fed their offspring until weaning. Then, offspring continued to be fed with a basic diet until adulthood. Body weight and fasting blood glucose were measured weekly. Se content, oxidative stress indicators, and the protein expression of the PI3K/Akt signaling pathway were detected. GDM increased susceptibility to obesity in lactating offspring, with gender differences observed in adult offspring. The effect of Se deficiency on SOD activity only appeared in female offspring during adulthood but was shown in male offspring during weaning though it disappeared during adulthood. GDM and Se deficiency increased the risk of abnormal glucose metabolism in female offspring from weaning to adulthood but gradually decreased in male offspring. The influence on the expression of PI3K/Akt signaling pathway-related proteins showed the same trend. GDM and Se deficiency affected the growth and glucose metabolism of offspring through oxidative stress and PI3K/Akt signaling pathway-related proteins, and gender differences existed.
The marine East Indies: centre of origin?

Much of the argument about the existence or nonexistence of centres of origin has been focused on the marine East Indies. During the past 10 years, considerable new information has become available. Patterns suggesting historic dispersals from the East Indies have been described. It is now apparent that there is, in several animal groups, an increasing trend in average generic age from the East Indies outward. Paleontological studies have revealed significant onshore to offshore evolutionary trends during much of the Phanerozoic. Antitropical and other disjunct patterns in the Indo-West Pacific suggest that the ex- tinction process often begins in the East Indies and spreads outward. Widespread Indo-West Pacific species, that possibly originated in the East Indies, oc- casionally surmount biogeographic barriers to colo- nize adjacent regions. The biogeographic patterns described are compat- ible with, and provide support for, the centre of origin hypothesis. Successful evolution, which results in the formation of new phyletic lines, takes place in the nearshore waters of centres of origin. From such centres, new species, which may eventually give rise to new higher taxa, spread out both vertically and hor- izontally. As they spread vertically, they replace older forms from the mid- and outer shelf and eventually from the slope. As they spread horizontally, they replace their more generalized, peripheral relatives, leaving as evidence the historic dispersal and age pat- terns which have been noted.
Relationship between increased Taxation and Financial Performance of Kenyan Firms

Taxation plays a critical role in financing government activities, public services, and economic development. This study focuses on examining how taxation impacts the financial performance of firms in Kenya. The complex interplay between tax policies and financial outcomes is multifaceted, and understanding these dynamics is crucial for effective tax strategies and financial optimization. The theoretical frameworks of "Ability to Pay Theory," "Classical Taxation Theory," and "Political Power Theory" are explored to provide insight into the relationships between taxation and business performance. These theories help us understand how tax rates, incentives, and political influences can affect firms' profitability, investment, and overall financial performance. By reviewing existing literature and conducting empirical research, this study aims to shed light on the specific challenges and opportunities that taxation presents to businesses in Kenya. The study observed that the influence of taxation on the financial performance of Kenyan firms is significant and multifaceted. Understanding the effects of customs duty, PAYE, and VAT is crucial for informed decision-making and effective management of financial resources in the business environment. Further research should explore the specifics of these impacts and potential mitigating measures.
Axial length and anterior chamber indices in elderly population: Tehran Geriatric Eye Study.

AIM To determine the normative distribution of axial length (AL), anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), and some of their associated factors in subjects aged 60 and over. METHODS In this cross-sectional study, 160 clusters were sampled using multi-stage cluster sampling in Tehran, Iran. After a preliminary interview, the participants underwent optometric examinations including visual acuity and refraction measurement followed by slit lamp biomicroscopy. Finally, ocular imaging was done using the Pentacam AXL to measure AL, ACD, ACV, and ACA. RESULTS A total of 4519 eyes of 2436 participants were evaluated, of whom 58.0% (n=1412) were female. The mean age of the subjects was 67.32±6.05y (range: 60-95y). The mean AL, ACD, ACV, and ACA was 23.22 mm (23.18-23.27 mm), 2.61 mm (2.59-2.62 mm), 126.56 mm3 (125.08-128.04 mm3), and 30.61° (30.3°-30.92°), respectively. In the multivariable model, after adjusting for the effect of both eyes, the longest and shortest AL was seen in myopic and hyperopic subjects, respectively. AL, ACD, ACV and ACA were significantly larger in men compared to women (P<0.001). Except ACA, other evaluated parameters showed an inverse correlation with age (P<0.001), however, this correlation was insignificant for AL (P=0.623). CONCLUSION Normative value of AL, and other biometric parameters are specific for each ethnicity, age and sex group. Any alteration in these parameters and their effect on refraction should be considered in this age group, especially in case of cataract surgery.