Miracle-dz/UniFAR-FTUs huggingface dataset:
The Efficacy and Safety of the Zhuyun Formula and Auricular Acupressure for the Infertile Women with Recurrent Implantation Failure: A Randomized Controlled Trial

Background Recurrent implantation failure (RIF), a clinical disorder characterized by failure to achieve pregnancy after repeated (≥3) embryo transfer, is a challenge for reproductive demands worldwide. In our preliminary work, the Zhuyun formula (ZYF) with auricular acupressure, a complementary and alternative medicine (CAM) with a small sample size for RIF, can improve the clinical pregnancy rate (41.2% vs. 26.7%, treatment group vs. control group, p < 0.05). Based on the toxicological and pregnancy-related pharmacological analysis of ZYF for RIF, the T-cell receptor signaling pathway might be involved in the pharmacological activity. This study aimed at evaluating the efficacy and safety of the CAM therapy according to pregnancy outcomes and maternal and child health and investigating the changes of T-helper (Th) cells in the peripheral blood of unexplained RIF women. Materials and Methods We conducted a prospective, two-arms, randomized, nonblinded study. All eligible women were randomly assigned to the treatment group (TG) and the control group (CG) according to a computer-generated randomization list in sealed opaque envelopes. Blood samples were collected from the two groups, and serum Th1, Th2, and Treg were detected by flow cytometry. The cytokines were detected by an enzyme-linked immunosorbent assay (ELISA). The TG was administrated with ZYF and auricular acupressure for three months before ovarian stimulation, while the control group was on a waiting list for the same period. The primary outcome was CPR. The second outcomes were the serum levels of immune parameters. For the safety evaluation, the perinatal outcomes of maternal and child were obtained by follow-up. Post-hoc sensitivity analyses were performed to assess the effect of missing data. Results One hundred and twenty-three women were randomized into the TG (n = 62) and CG (n = 61). The CPR was increased significantly in the TG (45.2%) than CG (26.2%) (p = 0.029). Twenty blood samples were collected, and the Th2/Th1 and Treg expression level was significantly higher in the TG than in the CG. IL-2, IL-10, and Foxp3 were higher significantly in the TG than in the CG. The maternal and child perinatal outcomes were not significantly different between the two groups. Conclusions The ZYF with auricular acupressure was effective and safe in improving the pregnancy outcomes of RIF. It might be related to balancing the level of cytokines related to the immune tolerance of the maternal-fetal interface to protect the embryo from the maternal immune system. Clinical Trial Registration: Clinical Trial Registry; date: 14/Dec/2013; no. NCT03078205.
Digital inclusion in Spanish mainstream and special schools: Teachers' perceptions of Internet use by students with intellectual disabilities

Background Methods Findings Conclusion Although there is research‐based evidence on the educational potential of information and communication technologies as teaching and learning resources for schools, studies focused on the real benefits and risks associated with online activities of students with intellectual disabilities are still scarce. The purpose of this study was to describe and compare teachers' perspectives on this topic in relation to a school setting (mainstream and special schools), teaching specialty (general and special educators) and teaching level (primary and secondary education). A cross‐sectional survey design was conducted in which a sample of 208 general and special education teachers from mainstream and special schools participated. Participants had to respond to a questionnaire that included questions related to the opportunities and risks of the Internet and online safety.Teachers perceive that the Internet is unsafe for students with intellectual disabilities and it entails more risks than benefits for these students. Such perceptions may determine the educational intervention, especially when the Internet has shown to be crucial during the coronavirus disease 2019 pandemic. Differences were found regarding school setting, teaching specialty and teaching level. The data reflect a lack of consensus regarding the potential benefit of digital inclusion for students with intellectual disabilities, based on the perception that the online environment is not safe for this population.There is a need to train teachers on how to achieve the maximum educational potential of the Internet for these students, as well as to learn to implement strategies to prevent and manage online risks. [ FROM AUTHOR] Copyright of British Journal of Learning Disabilities is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
The metallicity properties of simulated long-GRB galaxy hosts and the Fundamental Metallicity Relation

We study the implication of the collapsar model for Long Gamma-Ray Bursts (LGRBs) on the metallicity properties of the host galaxies, by combining high-resolution N-body simulations with semi-analytic models of galaxy formation. The cosmological model that we use reproduces the Fundamental Metallicity Relation recently discovered for the SDSS galaxies, whereby the metallicity decreases with increasing Star Formation Rate for galaxies of a given stellar mass. We select host galaxies housing pockets of gas-particles, young and with different thresholds in metallicities, that can be sites of LRGB events, according to the collapsar model. The simulated samples are compared with 18 observed LGRB hosts in the aim at discriminating whether the metallicity is a primary parameter. We find that a threshold in metallicity for the LGRB progenitors, within the model galaxies, is not necessary in order to reproduce the observed distribution of host metallicities. The low metallicities of observed LGRB hosts is a consequence of the high star formation environment. The star formation rate appears to be the primary parameter to generate a burst event. Finally, we show that only a few LGRBs are observed in massive, highly extincted galaxies, while these galaxies are expected to produce many such events. We identify these missing events with the fraction of dark LGRBs.
The pre-inflationary dynamics of loop quantum cosmology: confronting quantum gravity with observations

Using techniques from loop quantum gravity, the standard theory of cosmological perturbations was recently generalized to encompass the Planck era. We now apply this framework to explore pre-inflationary dynamics. The framework enables us to isolate and resolve the true trans-Planckian difficulties, with interesting lessons both for theory and observations. Specifically, for a large class of initial conditions at the bounce, we are led to a self consistent extension of the inflationary paradigm over the 11 orders of magnitude in density and curvature, from the big bounce to the onset of slow roll. In addition, for a narrow window of initial conditions, there are departures from the standard paradigm, with novel effects—such as a modification of the consistency relation between the ratio of the tensor to scalar power spectrum and the tensor spectral index, as well as a new source for non-Gaussianities—which could extend the reach of cosmological observations to the deep Planck regime of the early universe. Communicated by P Singh
Neutron tomography of magnetic Majorana fermions in a proximate quantum spin liquid

Quantum matter provides an effective vacuum out of which arise emergent particles not corresponding to any experimentally detected elementary particle. Topological quantum materials in particular have become a focus of intense research in part because of the remarkable possibility to realize Majorana fermions, with their potential for new, decoherence-free quantum computing architectures. In this paper we undertake a study on high-quality single crystal of -RuCl3 which has been identified as a material realizing a proximate Kitaev state, a topological quantum state with magnetic Majorana fermions. Four-dimensional tomographic reconstruction of dynamical correlations measured using neutrons is uniquely powerful for probing such magnetic states. We discover unusual signals, including an unprecedented column of scattering over a large energy interval around the Brillouin zone center which is remarkably stable with temperature. This is straightforwardly accounted for in terms of the Majorana excitations present in Kitaev's topological quantum spin liquid. Other, more delicate, features in the scattering can be transparently associated with perturbations to an ideal model. This opens a window on emergent magnetic Majorana fermions in correlated materials.
Preferable and limiting conditions of trans-Palearctic Orthocephalus species (Heteroptera: Miridae)

The environmental conditions limiting the distribution of trans-Palearctic species from various groups remain poorly studied. This work addresses the topic from three perspectives: (1) analysis of climatic variables, biomes and climate zones corresponding to the actual records; (2) assessment of environmental niches and contribution of biomes to those niches; (3) comparison of the distributional limits of trans-Palearctic and more local species. The genus Orthocephalus (Insecta: Heteroptera: Miridae) is used as a model taxon. The results have demonstrated that all trans-Palearctic species of this genus are known from numerous biomes and climate zones, but each of them has unique preferences. Biomes significantly contribute to the environmental niches of some of those species. None of the trans-Palearctic species were recorded from the hot steppe and desert climate zones, which occupy large areas in the Palearctic, although certain rare and local species inhabit those regions. This means that the trans-Palearctic species cannot easily adapt to those conditions.
Mathematical problems for miscible, incompressible fluids with Korteweg stresses

The equations governing the motion and diffusion of miscible liquids can be reduced to a form like the Navier-Stokes equations when the equation of state is for the density of a simple mixture. In particular, in this case, W=Cu+D⊇φ, where C and D are constant, is solenoidal. This allows one to introduce a generalized stream and diffusion function which may be useful in the study of two-dimensional problems. Problems of unidirectional shearing flows in the presence of gradients of composition are briefly considered
Revised physical elements of the astrophysically important O9.5+O9.5V eclipsing binary system Y Cygni ,,

Context. Rapid advancements in light-curve and radial-velocity curve modelling, as well as improvements in the accuracy of observations, allow more stringent tests of the theory of stellar evolution. Binaries with rapid apsidal advance are particularly useful in this respect since the internal structure of the stars can also be tested. Aims. Thanks to its long and rich observational history and rapid apsidal motion, the massive eclipsing binary Y Cyg represents one of the cornerstones of critical tests of stellar evolutionary theory for massive stars. Nevertheless, the determination of the basic physical properties is less accurate than it could be given the existing number of spectral and photometric observations. Our goal is to analyse all these data simultaneously with the new dedicated series of our own spectral and photometric observations from observatories widely separated in longitude. Methods. We obtained new series of UBV observations at three observatories separated in local time to obtain complete light curves of Y Cyg for its orbital period close to 3 days. This new photometry was reduced and carefully transformed to the standard UBV system using the HEC22 program. We also obtained new series of red spectra secured at two observatories and re-analysed earlier obtained blue electronic spectra. Reduction of the new spectra was carried out in the IRAF and SPEFO programs. Orbital elements were derived independently with the FOTEL and PHOEBE programs and via disentangling with the program KOREL. The final combined solution was obtained with the program PHOEBE. Results. Our analyses provide the most accurate value of the apsidal period of (47.805 ± 0.030) yr published so far and the following physical elements: M1 = 17.72 ± 0.35 M� , M2 = 17.73 ± 0.30 M� , R1 = 5.785 ± 0.091 R� ,a ndR2 = 5.816 ± 0.063 R� . The disentangling thus resulted in the masses, which are somewhat higher than all previous determinations and virtually the same for both stars, while the light curve implies a slighly higher radius and luminosity for star 2. The above empirical values imply the logarithm of the internal structure constant log k2 = −1.937. A comparison with Claret’s stellar interior models implies an age close to 2 × 10 6 yr for both stars. Conclusions. The claimed accuracy of modern element determination of 1–2 per cent still seems a bit too optimistic and obtaining new high-dispersion and high-resolution spectra is desirable.
Mathematical Model for Adaptive Technology in E-learning Systems

: The emergence of a large number of e-learning platforms and courses does not solve the problem of improving the quality of education. This is primarily due to insufficient implementation or lack of mechanisms for adaptation to the individual parameters of the student. The level of adaptation in modern e-learning systems to the individual characteristics of the student makes the organization of human-computer interaction relevant. As the solution of the problem, a mathematical model of the organization of human-computer interaction was proposed in this work. It is based on the principle of two-level adaptation that determines the choice of the most comfortable module for studying at the first level. The formation of an individual learning path is performed at the second level. The problem of choosing an e-module is solved using a fuzzy logic. The problem of forming a learning path is reduced to the problem of linear programming. The input data are the characteristics of the quality of student activity in the education system. Based on the proposed model the computer technology to support student activities in modular e-learning systems is developed. This technology allows increasing the level of student’s cognitive comfort and optimizing the learning time. The most important benefit of the proposed approach is to increase the average score and increase student satisfaction with learning.
Searching for IMBHs in Galactic globular clusters through radial velocities of individual stars

Abstract I present an overview of our ongoing project aimed at building a new generation of velocity dispersion profiles ad rotation curves for a representative sample of Galactic globular clusters, from the the radial velocity of hundreds of individual stars distributed at different distances from the cluster center. The innermost portion of the profiles will be used to constrain the possible presence of intermediate-mass black holes. The adopted methodology consists of combining spectroscopic observations acquired with three different instruments at the ESO-VLT: the adaptive-optics assisted, integral field unit (IFU) spectrograph SINFONI for the innermost and highly crowded cluster cores, the multi-IFU spectrograph KMOS for the intermediate regions, and the multi-fiber instrument FLAMES/GIRAFFE-MEDUSA for the outskirts. The case of NGC 6388, representing the pilot project that motivated the entire program, is described in some details.
Government Spending on Infrastructure and Private Investment: A Disaggregated Analysis

Limited empirical studies have disaggregated the government spending into infrastructure and consumption expenditures in this thematic area. More so, Kenya has witnessed a tremendous increase in spending on infrastructural projects such as highways, road, ports, fiber optic, standard gauge railway, and massive investment in road management and maintenance. All these efforts are meant to accelerate the realization of the Kenya Vision 2030 as well as the ‘Big Four’ agenda of the Kenyan government. The aim of this research was to investigate the role of infrastructure sector spending on private investment in the country. The study used secondary data for 1963 to 2018 from annual statistical abstracts and economic surveys report. To achieve the outlined objective, the study adopted Autoregressive Distributed Lag (ARDL) technique and the Error Correction Model (ECM) estimation approach. Infrastructure outlay in health, agriculture and roads was found to positively impact private investment in the long run. On the contrary, defense and education development spending influence private investment negatively in the long run. This paper concludes that public sector infrastructure outlays are key in determining private investment and that different public spending component affect investment differently in both long- run and short- run. This study recommends that the government should consider increasing and sustaining spending on infrastructure development projects like roads, ports, fiber optic, railways, highways maintenance, agriculture mechanization, improving public health infrastructure to stimulate further the economic activities.
EXTREMELY METAL-POOR GALAXIES: THE ENVIRONMENT

We have analyzed bibliographical observational data and theoretical predictions, in order to probe the environment in which extremely metal-poor dwarf galaxies (XMPs) reside. We have assessed the H i component and its relation to the optical galaxy, the cosmic web type (voids, sheets, filaments and knots), the overdensity parameter and analyzed the nearest galaxy neighbors. The aim is to understand the role of interactions and cosmological accretion flows in the XMP observational properties, particularly the triggering and feeding of the star formation. We find that XMPs behave similarly to Blue Compact Dwarfs; they preferably populate low-density environments in the local universe: ∼60% occupy underdense regions, and ∼75% reside in voids and sheets. This is more extreme than the distribution of irregular galaxies, and in contrast to those regions preferred by elliptical galaxies (knots and filaments). We further find results consistent with previous observations; while the environment does determine the fraction of a certain galaxy type, it does not determine the overall observational properties. With the exception of five documented cases (four sources with companions and one recent merger), XMPs do not generally show signatures of major mergers and interactions; we find only one XMP with a companion galaxy within a distance of 100 kpc, and the H i gas in XMPs is typically well-behaved, demonstrating asymmetries mostly in the outskirts. We conclude that metal-poor accretion flows may be driving the XMP evolution. Such cosmological accretion could explain all the major XMP observational properties: isolation, lack of interaction/merger signatures, asymmetric optical morphology, large amounts of unsettled, metal-poor H i gas, metallicity inhomogeneities, and large specific star formation.
Primary Palliative Care in Huntington's Disease

Palliative care practices, including communication about patient‐centered goals of care and advance care planning (ACP), have the potential to enhance care throughout the course of Huntington's disease (HD) and related disorders. The goal of our project was to develop a pilot program that integrates primary palliative care practices with interdisciplinary care for HD.
Towards an understanding of the evolution of the scaling relations for supermassive black holes

The growth of the supermassive black holes (BHs) that reside at the centres of most galaxies is intertwined with the physical processes that drive the formation of the galaxies themselves. The evolution of the relations between the mass of the BH, m_BH, and the properties of its host therefore represent crucial aspects of the galaxy formation process. We use a cosmological simulation, as well as an analytical model, to investigate how and why the scaling relations for BHs evolve with cosmic time. We find that a simulation that reproduces the observed redshift zero relations between m_BH and the properties of its host galaxy, as well as the thermodynamic profiles of the intragroup medium, also reproduces the observed evolution in the ratio m_BH/m_s for massive galaxies, although the evolution of the m_BH/sigma relation is in apparent conflict with observations. The simulation predicts that the relations between m_BH and the binding energies of both the galaxy and its dark matter halo do not evolve, while the ratio m_BH/m_halo increases with redshift. The simple, analytic model of Booth & Schaye (2010), in which the mass of the BH is controlled by the gravitational binding energy of its host halo, quantitatively reproduces the latter two results. Finally, we can explain the evolution in the relations between m_BH and the mass and binding energy of the stellar component of its host galaxy for massive galaxies (m_s~10^11 M_sun) at low redshift (z<1) if these galaxies grow primarily through dry mergers.
Pengaruh Fraud Hexagon Terhadap Kecurangan Laporan Keuangan Pada Perusahaan LQ 45 Yang Terdaftar di Bursa Efek Indonesia Periode 2016-2020

Financial statement fraud is a misrepresentation and intentional concealment of facts on account values in the financial statements which results in irrelevant financial information. Fraudulent financial statements can lead to internal and external conflicts within a company that can harm decision makers. This study aims to determine the effect of the fraud hexagon which consists of pressure (external pressure), capability (change of director's), opportunity (nature of industry), rationalization (auditor's opinion), arrogance (frequent number of CEO's picture), and collusion (government projects) simultaneously or partially against fraudulent financial statements on LQ 45 index companies listed on the Indonesia Stock Exchange for the 2016-2020 period. This study uses purposive sampling technique in determining the sample in order to obtain 24 companies in the LQ 45 index listed on the Indonesia Stock Exchange. This study uses a descriptive type of research with logistic regression analysis techniques using SPSS 25 software. The results of this study indicate that pressure, capability, opportunity, rationalization, arrogance, and collusion have a simultaneous effect on financial statement fraud. The partial test results show that rationalization, arrogance have a positive effect and pressure, capability, opportunity, collusion have no effect on financial statement fraud on LQ 45 index companies listed on the Indonesia Stock Exchange for the 2016-2020 period.