Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunoinformatics design of multi-epitope peptide for the diagnosis of Schistosoma haematobium infection

Abstract Schistosoma haematobium has been identified as a significant cause of urogenital disease, as well as a risk factor for bladder cancer and HIV/AIDS. The parasites are obtained trans-dermally by swimming or wading in contaminated freshwater, and they are also transmitted to humans by freshwater snails. The organisms infect the vasculature of the gastrointestinal or genitourinary tracts. Worms live in blood vessels and lay eggs that become embedded in the bladder wall, causing chronic immune-mediated disease and squamous cell carcinoma growth. The primary goal of this research is to predict and design a novel synthetic protein containing multiple immunodominant B cell epitopes using three schistosome proteins: XP-012801068.2, XP-012801892.2, and XP-012793835.2 softwares were used to analyze the proteins’ primary, secondary, and tertiary structures (BepiPred, BcPred). The B cell construct was then evaluated using I-TASSER server, and physicochemical properties, as well as homology modeling of the 3 D structure of the protein, was obtained. In silico analyses revealed regions with high immunogenicity. For XP-012801068.2, three epitopes are found between residues 292–334, 3–22, and 314–333; for XP-012801892.2, three epitopes are found in the residues 184–236, 81–100, and 329–348 for XP-012793835.2, four epitopes are found in the residues 185–222, 469–512, 649–713, and 338–357. The construct’s has an average length of 308 bp, instability index of 49.96, theoretical PI of 4.2 and a C score −1.59. Furthermore, these parameters analyzed reveals that the constructed multi-epitope peptide has the potential to provide a theoretical basis for the development of a Schistosoma haematobium diagnostic kit. Communicated by Ramaswamy H. Sarma
Direct Exposure to Green and Blue Spaces is Associated with Greater Mental Wellbeing in Older Adults

Abstract Exposure to the natural environment may benefit individuals’ mental health, but quantitative evidence for older adults is limited. We used Experience Sampling Method to collect 2,774 reports on daily experiences from 200 adults aged 65 and above living in Poland. Multilevel mixed effects logistic regression models examined the association between individuals’ location and their self-reported stress and enjoyment. Being in green and blue spaces was associated with significantly lower odds of experiencing stress and significantly higher odds of experiencing enjoyment net of other individual-level and situational factors. Accessible green and blue spaces may help improve older adults’ psychological wellbeing.
Developmental Trajectories of Preschool Children’s Bullying Behavior: Prediction of Peer Relationships

A longitudinal study was conducted with 425 preschool children during a one-and-a-half-year period to investigate the developmental trajectory of preschool children’s bullying behavior and the prediction of peer relationships in this trajectory. The latent growth curve model (LGCM) and mixed growth model (GMM) were conducted on Mplus to investigate the normative development trajectory and heterogeneity of preschool children’s bullying behavior. Results showed that: (1) In general, preschool children’s bullying increased with age, and two significantly different sub-trajectories were identified through the model-fitting parameters. One was the “low-slow increasing” group, accounting for 88.47% of participants; the other group was the “high-fast decreasing” group, accounting for 11.53% of participants. (2) Peer rejection positively predicted preschool children’s bullying behavior, while peer acceptance and gender were not significant predictors. This study uncovered preschool children’s bullying behavior from a developmental perspective and provided further theoretical evidence for future intervention programs to reduce bullying behaviors.
Influence of attack angle on vortex-induced vibration and energy harvesting of two cylinders in side-by-side arrangement

The vortex-induced vibration and energy harvesting of two cylinders in side-by-side arrangement with different attack angles are numerically investigated using two-dimensional unsteady Reynolds-Averaged Navier–Stokes simulations. The Reynolds number ranges from 1000 to 10,000, and the attack angle of free flow is varied from 0° to 90°. Results indicate that the vortex-induced vibration responses with attack angle range of 0°≤ α ≤ 30° are stronger than other attack angle cases. The parallel vortex streets are clearly observed with synchronized vortex shedding. Relatively large attack angle leads to a phase difference between the wake patterns of the two cylinders. Hydrokinetic energy can be obviously harvested when Re > 4000. Compared with the larger attack angle case, the two side-by-side cylinders with smaller attack angle have better performance on energy conversion. The maximum energy conversion efficiency of 21.7% is achieved. The optimum region for energy conversion is 5000 ≤ Re ≤ 7000 and 0°≤ α ≤ 30°.
Opium use and risk of lung cancer: A multicenter case‐control study in Iran

Opium use was recently classified as a human carcinogen for lung cancer by the International Agency for Research on Cancer. We conducted a large, multicenter case‐control study evaluating the association between opium use and the risk of lung cancer. We recruited 627 cases and 3477 controls from May 2017 to July 2020. We used unconditional logistic regression analyses to estimate the odds ratios (OR) and 95% confidence intervals (CI) and measured the association between opium use and the risk of lung cancer. The ORs were adjusted for the residential place, age, gender, socioeconomic status, cigarettes, and water pipe smoking. We found a 3.6‐fold risk of lung cancer for regular opium users compared to never users (95% CI: 2.9, 4.6). There was a strong dose‐response association between a cumulative count of opium use and lung cancer risk. The OR for regular opium use was higher for small cell carcinoma than in other histology (8.3, 95% CI: 4.8, 14.4). The OR of developing lung cancer among opium users was higher in females (7.4, 95% CI: 3.8, 14.5) than in males (3.3, 95% CI: 2.6, 4.2). The OR for users of both opium and tobacco was 13.4 (95% CI: 10.2, 17.7) compared to nonusers of anything. The risk of developing lung cancer is higher in regular opium users, and these results strengthen the conclusions on the carcinogenicity of opium. The association is stronger for small cell carcinoma cases than in other histology.
Role of Educational Planning in Ensuring Quality Education of Morogoro Municipality in Tanzania

This study aimed at probing the role of educational planning in ensuring quality education of Morogoro Municipality in Tanzania. Its specific objectives were to: highlight educational planning approaches; find out the contribution(s) of educational planning to quality education and to determine the challenges facing educational planning in ensuring quality education. Adams’ interactive and rational models of educational planning served as a frame of reference for this study. The study adopted the survey research design. Data collection instruments consisted of questionnaires, interview and document review. Quantitative data was analyzed through SPSS (Statistical Package for Social Sciences) while qualitative data was subjected to content analysis for discussion. The study consisted of 40 participants for quantitative data and 6 participants for qualitative data. Whereas academic masters/mistresses and head teachers were purposively selected, teachers were randomly sampled. The findings of this study, unveiled that Tanzania employs the Social Demand Approach (SDA) of educational planning. Quality education indicators were presented as evidence of the role played by educational planning in ensuring quality. It was found that form IV students’ academic performance significantly improved as evidenced by NECTA (National Examinations Council of Tanzania) results from 2016 to 2020. Other quality indicators reported were, teachers’ qualifications, student-teacher ratios, infrastructure, teaching and learning materials and conducive learning environment. Despite academic improvement indicating better quality of education there were still some challenges to quality-oriented educational planning. The challenges highlighted were inadequate funding, insufficient laboratory equipment, low salaries, political interventions, parental indifference and shortage of science teachers. Planners are therefore urged to deconstruct and reconstruct educational planning so as to facilitate constructive resolutions to these challenges at grassroots level. In addition to allocation of educational funds to schools accordingly, increased involvement of teachers in educational planning is recommended. Prospective research on participatory educational planning for holistic quality education is encouraged.
Clinicopathological Features of Inflammatory Myofibroblastic Tumor in the Breast

Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. Because of the lack of typical imaging and clinical characteristics of IMT, it is easy to misdiagnose before operation. We now report a case of a 37-year-old woman presenting with a mass in her left breast. Ultrasound showed a well-circumscribed lesion in the lower outer quadrant. The patient underwent lumpectomy, and histopathology revealed a tumor which was composed of fusiform cells and inflammatory cells. Immunohistochemistry (IHC) showed tumor cells are positive for vimentin, ALK, BCL2, and SMA. The FISH test demonstrated ALK (2p23) chromosomal translocation (ALK positive). The final diagnosis of breast IMT was rendered with nonclassical morphology. Postoperative 30-month follow-up no evidence showed residual tumor or recurrence. As a very rare tumor, breast IMT could be easily misdiagnosed clinically and pathologically. Complete surgical resection of the tumor is preferred, and it has the risk of recurrence and metastasis.
Machine learning, pharmacogenomics, and clinical psychiatry: predicting antidepressant response in patients with major depressive disorder

ABSTRACT Introduction The efficacy of antidepressants for patients with major depressive disorder (MDD) varies from individual to individual, making the prediction of therapeutic outcomes difficult. Better methods for predicting antidepressant outcomes are needed. However, complex interactions between biological, psychological, and environmental factors affect outcomes, presenting immense computational challenges for prediction. Using machine learning (ML) techniques with pharmacogenomics data provides one pathway toward individualized prediction of therapeutic outcomes of antidepressants. Areas covered This report systematically reviews the methods, results, and limitations of individual studies of ML and pharmacogenomics for predicting response and/or remission with antidepressants in patients with MDD. Future directions for research and pragmatic considerations for the clinical implementation of ML-based pharmacogenomic algorithms are also discussed. Expert opinion ML methods utilizing pharmacogenomic and clinical data demonstrate promising results for predicting short-term antidepressant response. However, predictions of antidepressant treatment outcomes depend on contextual factors that ML algorithms may not be able to capture. As such, ML-driven prediction is best viewed as a companion to clinical judgment, not its replacement. Successful implementation and adoption of methods predicting antidepressant response warrants provider education about ML and close collaborations between computing scientists, pharmacogenomic experts, health system engineers, laboratory medicine experts, and clinicians.
Voices from the Frontlines: The Challenges and Rewards of Immigration Activism

This consensual qualitative research study explored immigration activists’ perspectives on the rewards and challenges of their work, how they cope with challenges, and their recommendations for how psychologists could best support them. Fifteen self-identified immigration activists completed one-hour, semi-structured, individual interviews. Analysis yielded 25 categories associated with six domains (Catalysts for Activism; Vision for Activism; Rewards; Challenges; Coping Strategies; and Recommendations for Psychological Practice, Research, and Advocacy). Participants reported emotional distress and burnout, but this challenge co-occurred with rewards such as connecting with colleagues or increased skills and tools. Activists used a variety of coping strategies, including maintaining boundaries, and encouraged psychologists to provide them with psychoeducational training, to provide services that are relevant and accessible to immigrant communities, and to advocate for immigration issues. The findings are placed in context with prior research pertaining to social identity, social justice activism, and multicultural competence.
Estudo dos limiares de audibilidade nas altas freqüências em indivíduos normo-ouvintes de 12 a 19 anos

This work had as a proposal to determine the high frequency auditory threshold (9000 to 16000 Hz) in normal listener individuals, from 12 to 19 years old, being 28 female and 34 male. Of the 62 pacients, 17 were eliminated (8 men and 9 women), because they demonstred some kind of problem on their audiometry and/or on their imitanciometry. All the 45 individuals went through audiologic anamnesys, meatoscopy, basic audiologic assessment and high frequency audiometry.The results demonstred: a) there weren‘t significant statistic differences between the sex ears variables; b) the auditory acuity decreases progressively as the tested frequency gets higher; c) the auditory threshold remains stable until 10000 Hz frequency, occuring a gradual rasing of this thresholds beginning at the 11200 Hz frequency.
In Vitro and In Vivo Analysis of the Effects of 3D-Printed Porous Titanium Alloy Scaffold Structure on Osteogenic Activity

The effect of titanium scaffold geometry on the bone regeneration ability of the scaffold remains unclear. Here, selective laser melting as a 3D printing technology was used to create porous titanium alloy scaffolds with two unit structures: a hollow hexagonal prism (group A) and a hollow triangular prism (group B). The structures and morphologies of the scaffolds were characterized before mechanical properties were simulated. Cell adhesion behaviors, osteoblast activity and proliferation, and alkaline phosphatase (ALP) activity were evaluated, in addition to in vivo testing in an animal model. The results showed that the two scaffolds made of Ti6Al4V had compression moduli similar to that of human cortical bone (116.91 ± 0.01 and 174.29 ± 2.21 MPa vs. 89–164 MPa). The two scaffolds were nontoxic to cells and had good biocompatibility, while group A scaffolds facilitated cell adhesion. The number of cells increased gradually in culture. The ALP activity of cells on group A scaffolds demonstrated higher osteogenic ability than that of group B scaffolds. The in vivo tests showed that all scaffolds retained their shape well after implantation, and no obvious inflammatory reaction or infection in surrounding tissues was found. Based on fluorescence staining, mature new bone formation was found at week 12. Group A scaffolds showed better bone integration ability compared with group B scaffolds. The percentage of new bone area in group A (7.5%) was higher than that in group B (6.5%). This research suggests that the hollow hexagonal prism structure of porous scaffolds can promote osteogenic differentiation and osseointegration better than the triangular prism structure.
A review of pathophysiology, mortality, risk factors and protective measures of acute kidney injury in COVID-19 patients with underlying kidney disease and kidney transplants recipients

Acute kidney injury (AKI) is the second prevalent organ damage among COVID-19 infected individuals, which mainly affects those with critical diseases or underlying kidney disorders. Emerging data have suggested that AKI is associated with adverse outcomes, severe COVID-19 disease, and high mortality. However, the true nature and pathophysiology of COVID-19-associated kidney injury, and its effect on patients with underlying kidney diseases and transplant recipients, still remains controversial. Accordingly, this review study aimed primarily to describe the history of AKI in COVID-19 infected patients and to achieve a robust understanding of the latest findings on the mechanism of the injury. Secondly, this systematic and precise review of the literature concerning the aspects of AKI in infected patients with chronic kidney disease and transplant recipients provided a comprehensive report of mortality in these individuals. Finally, the present research suggested the possible protective measures that physicians can take to prevent, control, and treat this condition. Our study paves the way for future works with a more robust methodology to better understand COVID-19-related kidney injury.
Participatory Newspapers: A Thematic Analysis of Online News Articles and Readers’ Comments

E-newspapers have become inescapable sources of information thanks to their accessibility and interactivity. In their commentary sections, these digital platforms have given voice to their audience to have their say in what is reported. Yet, despite the popularity of such digital platforms, little is known about their interactive communication process, production and consumption. Accordingly, this study tires to investigate the interactive aspect of the most popular Moroccan e-newspaper, Hespress, in the way its journalists and readers represent the issue of irregular migration in Morocco. A thematic analysis was conducted to identify the dominant thematic patterns representing the issue of irregular migration in Hespress news articles and readers’ comments.
sCD40L Is Increased and Associated with the Risk of Gestational Diabetes Mellitus in Pregnant Women with Isolated TPOAb Positivity

Background Autoimmune disorders are associated with gestational diabetes mellitus (GDM) in pregnant women who were positive for thyroid peroxidase antibody (TPOAb). Soluble CD40 ligand (sCD40L) and soluble interleukin-2 receptor (sCD25) are abnormally expressed in autoimmune diseases and are reliable markers of inflammation. The purpose of this study was to evaluate sCD40L and sCD25 in early pregnancy and investigate their correlation with GDM and TPOAb. Methods A total of 126 pregnant women in the first trimester were enrolled for analysis: 93 were positive for TPOAb and 33 were negative for TPOAb. Demographical and clinical data in early pregnancy were collected. A total of 123 participants underwent a 75 g oral glucose tolerance test in the second trimester. Serum sCD40L and sCD25 levels were measured by ELISA. Results The incidence of GDM was 24.4% in pregnant women with isolated TPOAb positivity in our study. Both sCD40L and sCD25 were positively correlated with TPOAb (r = 0.476, P < 0.001; r = 0.188, P < 0.05). sCD40L was highest in (P < 0.001) Ab-positive women with GDM group (P < 0.05). After adjusting for TPOAb, age, TSH, FT4, triglycerides, and low-density lipoprotein cholesterol, multivariate logistic regression analysis showed that sCD40L was an independent risk factor for GDM in pregnant women with TPOAb positivity (odds ratio = 3.235, 95% confidence interval 1.024–10.218, P < 0.05). Conclusions About a quarter of pregnant women with isolated positive TPOAb might have GDM. sCD40L was an independent risk factor for GDM in women with isolated TPOAb positivity.
Total Quality Management in Services

Although quality improvement is being sought, and total quality management is being applied in the service sector, the majority of applications which have been described are in environments similar to manufacturing in some important respects. Some of the cases are, nevertheless, concerned with issues such as: seeking to achieve better service by programmes to shape employee behaviour, encouraging attention to the customer’s requirements, and coping with the inherent variability engendered by interaction between employees and customers; and as such are particularly relevant to the distinctly “service” aspects of businesses. As a precursor to improving service quality it is necessary to be able to define and measure quality in that context. Research which seeks to show that consumers’ perceptions of service quality are based on the difference between their actual experience of the service and what they expected form a platform for both definition and measurement. Reviews the models of service quality which .
An Experimental Study on Flexural Behaviors of Reinforced Concrete Member Replaced Heavyweight Waste Glass as Fine Aggregate under Cyclic Loading

The development of electronic technology has accelerated in recent decades. Consequently, electronic wastes such as cathoderay tube (CRT) glass are accumulated, and hazardous wastes including heavy metals are generated. Simultaneously, natural resources are required to create concrete; however, they are already exhausted. Furthermore, heavyweight waste glass is considered to be the most suitable substitute for aggregate owing to its physical characteristics and chemical composition. However, structural results regarding the recycling of heavyweight waste glass as fine aggregate in Reinforced Concrete (RC) members are insufficient. Thus, herein, experimental study is conducted to evaluate whether RC members with heavyweight waste glass as fine aggregate can be applied for concrete structures. Flexural behavior tests of reinforced concrete members were performed. Fifteen specimens with different substitution ratios of heavyweight waste glass were prepared. The results showed that when all the fine aggregate is replaced by heavyweight waste glass in RC members, the heavyweight waste glass substitution ratio affected the crack occurrence patterns, and the possibility of a sudden failure of a member increased owing to concrete crushing in the compression zone. Additionally, the load capacity and flexural rigidity were affected by the substitution ratio of heavyweight waste glass; however, the flexural performance is improved when mineral admixture as a binder or a low water-binder ratio were used. Therefore, heavyweight waste glass is considered applicable for use as fine aggregate of concrete.
THE EFFECT OF FEE-BASED INCOME, THIRD PARTY FUNDS, AND PROFIT SHARING RATES ON THE NET PROFIT OF ISLAMIC BANKS FOR THE 2016-2020 PERIOD

The purpose of this study is to determine the effect of Fee Based Income, Third Party Funds, and Profit Sharing Rates on Net Profit in Islamic Commercial Banks with the research period from 2016-2020. This study used quantitative methods, while the type of data used is secondary data. The populations in Islamic Commercial Banks with the research period from 2016-2020. The number of samples used in this study were 6 Bank determined by using purposive sampling method based on predetermined criteria. The result revealed that Fee Based Income insignificant effect on Net Profit, Third Party Funds significant effect on Net Profit, and Profit Sharing Rates insignificant effect on Net Profit. Simultaneously Fee Based Income, Third Party Funds, and Profit Sharing Rates significant effect on Net Profit in Islamic Commercial Banks with the research period from 2016-2020. The R-Squared result is 0.315090 or 0.31% the dependent variable is influenced by the independent variable in the model. Meanwhile, the remaining 69% is influenced by other variables outside the model such as Non Performing Financing, Financing to Deposit Ratio, Inflation, BI 7-Day Reserve Repo Rate, Inflation Rate, Own Capital, and Lease Financing.