Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuronally expressed a‐series gangliosides are sufficient to prevent the lethal age‐dependent phenotype in GM3‐only expressing mice

Gangliosides are expressed on plasma membranes throughout the body and enriched in the nervous system. A critical role for complex a‐ and b‐series gangliosides in central and peripheral nervous system ageing has been established through transgenic manipulation of enzymes in ganglioside biosynthesis. Disrupting GalNAc‐transferase (GalNAc‐T), thus eliminating all a‐ and b‐series complex gangliosides (with consequent over‐expression of GM3 and GD3) leads to an age‐dependent neurodegeneration. Mice that express only GM3 ganglioside (double knockout produced by crossing GalNAc‐T−/− and GD3 synthase−/− mice, Dbl KO) display markedly accelerated neurodegeneration with reduced survival. Degenerating axons and disrupted node of Ranvier architecture are key features of complex ganglioside‐deficient mice. Previously, we have shown that reintroduction of both a‐ and b‐series gangliosides into neurons on a global GalNAcT−/− background is sufficient to rescue this age‐dependent neurodegenerative phenotype. To determine the relative roles of a‐ and b‐series gangliosides in this rescue paradigm, we herein reintroduced GalNAc‐T into neurons of Dbl KO mice, thereby reconstituting a‐series but not b‐series complex gangliosides. We assessed survival, axon degeneration, axo–glial integrity, inflammatory markers and lipid‐raft formation in these Rescue mice compared to wild‐type and Dbl KO mice. We found that this neuronal reconstitution of a‐series complex gangliosides abrogated the adult lethal phenotype in Dbl KO mice, and partially attenuated the neurodegenerative features. This suggests that whilst neuronal expression of a‐series gangliosides is critical for survival during ageing, it is not entirely sufficient to restore complete nervous system integrity in the absence of either b‐series or glial a‐series gangliosides.
Health warning labels and alcohol selection: a randomised controlled experiment in a naturalistic shopping laboratory.

BACKGROUND AND AIMS Health warning labels (HWLs) on tobacco products reduce smoking. There is an absence of evidence concerning the impact of alcohol HWLs on selection or purchasing in naturalistic settings. Using a commercial-standard naturalistic shopping laboratory, this study aimed to estimate the impact on selection of alcoholic drinks of HWLs describing adverse health consequences of excessive alcohol consumption. DESIGN A between-subjects randomised experiment with three groups was conducted: Group 1: image-and-text HWL; Group 2: text-only HWL; Group 3: no HWL. SETTING A commercial-standard naturalistic shopping laboratory in the United Kingdom. PARTICIPANTS Adults (n=399, 55% female) over the age of 18, who purchased beer or wine weekly to drink at home. INTERVENTIONS Participants were randomised to one of three groups varying in the HWL displayed on the packaging of the alcoholic drinks: i. image-and-text HWL (n=135); ii. text-only HWL (n=129); iii. no HWL (n=135). Participants completed a shopping task, selecting items from a range of alcoholic and non-alcoholic drinks, and snacks. MEASUREMENT The primary outcome was the proportion of alcoholic drinks selected. Secondary outcomes included HWL ratings on negative emotional arousal and label acceptability. FINDINGS There was no clear evidence of a difference in the HWL groups for the percentage of drinks selected that were alcoholic compared to no HWL (44%): image-and-text HWL: 46% (OR=1.08, 95%CI=0.82,1.42); text-only HWL: 41% (OR=0.87, 95%CI=0.67,1.14). Concordant with there being no difference between groups, there was extreme evidence in favour of the null hypothesis (Bayes factor [BF] < 0.01). Negative emotional arousal was higher (p< 0.001) and acceptability lower (p< 0.001) in the image-and-text HWL group, compared to the text-only HWL group. CONCLUSIONS In a naturalistic shopping laboratory, there was no evidence that health warning labels describing the adverse health consequences of excessive alcohol consumption changed selection behaviour.
COVID-19 and vaccine hesitancy: A longitudinal study

How do attitudes toward vaccination change over the course of a public health crisis? We report results from a longitudinal survey of United States residents during six months (March 16 –August 16, 2020) of the COVID-19 pandemic. Contrary to past research suggesting that the increased salience of a disease threat should improve attitudes toward vaccines, we observed a decrease in intentions of getting a COVID-19 vaccine when one becomes available. We further found a decline in general vaccine attitudes and intentions of getting the influenza vaccine. Analyses of heterogeneity indicated that this decline is driven by participants who identify as Republicans, who showed a negative trend in vaccine attitudes and intentions, whereas Democrats remained largely stable. Consistent with research on risk perception and behavior, those with less favorable attitudes toward a COVID-19 vaccination also perceived the virus to be less threatening. We provide suggestive evidence that differential exposure to media channels and social networks could explain the observed asymmetric polarization between self-identified Democrats and Republicans.
Adverse Childhood Experiences, Suicidal/Self-Harming Thoughts, and Suicide Attempts Among LGB and Heterosexual Utahns

ABSTRACT Current research suggests that sexual minorities living in Utah may be at higher risk for experiencing suicidal/self-harming thoughts and suicide attempts than heterosexuals in Utah. However, to date no research has been conducted examining potential reasons sexual minorities living in Utah may be at higher risk. Using two representative samples of Utahns, we examine (a) disparities in adverse childhood experiences (ACEs) between sexual minorities and heterosexual Utahn, (b) how ACEs and sexual orientation may predict recent suicidal/self-harming thoughts and lifetime prevalence of suicide attempts, and (c) how sexual orientation and ACEs might interact to predict suicidal outcomes. Results with each sample showed that sexual minority Utahns reported higher levels of ACEs and suicidal/self-harming thoughts than heterosexual Utahns. Both sexual orientation and ACEs uniquely predicted suicidality when both were entered into regression models, but no interaction effects were found between these predictors.
Brazilian women’s use of evidence-based practices in childbirth after participating in the Senses of Birth intervention: A mixed-methods study

Brazil has a cesarean rate of 56% and low use of Intrapartum Evidence-based Practices (IEBP) of 3.4%, reflecting a medically centered and highly interventionist maternal health care model. The Senses of Birth (SoB) is a health education intervention created to promote normal birth, use of EBP, and reduce unnecessary c-sections. This study aimed to understand the use of intrapartum EBP by Brazilian women who participated in the SoB intervention. 555 women answered the questionnaire between 2015 and 2016. Bivariate analysis and ANOVA test were used to identify if social-demographic factors, childbirth information, and perceived knowledge were associated with the use of EBP. A qualitative analysis was performed to explore women’s experiences. Research participants used the following EBP: birth plan (55.2%), companionship during childbirth (81.6%), midwife care (54.2%), freedom of mobility during labor (57.7%), choice of position during delivery (57.2%), and non-pharmacological pain relief methods (74.2%). Doula support was low (26.9%). Being a black woman was associated with not using a birth plan or having doula support. Women who gave birth in private hospitals were more likely not to use the EBP. Barriers to the use of EBP identified by women were an absence of individualized care, non-respect for their choices or provision of EBP by health care providers, inadequate structure and ambiance in hospitals to use EBP, and rigid protocols not centered on women’s needs. The SoB intervention was identified as a potential facilitator. Women who used EBP described a sense of control over their bodies and perceived self-efficacy to advocate for their chosen practices. Women saw the strategies to overcome barriers as a path to become their childbirth protagonist. Health education is essential to increase the use of EBP; however, it should be implemented combined with changes in the maternal care system, promoting woman-centered and evidence-based models.
Strategic Mentoring: A Culturally Responsive Approach for Supporting Black Males

Young Black males living in single-parent homes, in spite of never having a mentor, understand the value of a responsible same-sex mentor. Thirteen Black males between the ages of eighteen and twenty-five offered well-expressed thoughts on mentoring and why they believe mentoring adds value to their lives. They characterized unstructured mentoring as a process without a specific agenda. The consideration of Black males struggling without a father in the home requires the serious consideration of strategic mentoring as a solution for change. Strategic mentoring has a clear purpose, is communication-centric, is designed to develop during the course of a long-term mutual commitment between mentor and mentee, and incorporates the child’s mother into the mentoring experience.
Towards rethinking the primacy of epistemology in psychology: Introduction to the special section

Within psychology, epistemology is treated by many scholars explicitly or implicitly as a default first principle. Within this special section, this positioning is brought into question. Contributors consider broadening the philosophical foundations of our discipline to also overtly include ethical, existential, and cosmological concerns alongside epistemology considerations. We present five articles that each showcase very different approaches in the reimagining of the philosophical principles of psychology. Although different in many ways, these contributions also share key similarities in advocating for the more meaningful inclusion of ethics within broader processes of knowledge production and implementation.
Pursuing Justice-Driven Inclusive Education Research: Disability Critical Race Theory (DisCrit) in Early Childhood

Multiple scholars have argued that early childhood inclusive education research and practice has often retained racialized, ableist notions of normal development, which can undermine efforts to advance justice and contribute to biased educational processes and practices. Racism and ableism intersect through the positioning of young children of Color as “at risk,” the use of normalizing practices to “fix” disability, and the exclusion of multiply marginalized young children from educational spaces and opportunities. Justice-driven inclusive education research is necessary to challenge such assumptions and reduce exclusionary practices. Disability Critical Race Theory extends inclusive education research by facilitating examinations of the ways racism and ableism interdependently uphold notions of normalcy and centering the perspectives of multiply marginalized children and families. We discuss constructions of normalcy in early childhood, define justice-driven inclusive education research and its potential contributions, and discuss DisCrit’s affordances for justice-driven inclusive education research with and for multiply marginalized young children and families.
Little pranksters: Inhibitory control mediates the association between false belief understanding and practical joking in young children

To successfully pull a practical joke on someone, children need to understand that their victims do not know what they themselves know, be able to intentionally manipulate others’ beliefs, and maintain a straight face to safeguard the integrity of the joke. This study examined the relationship between children’s developing theory of mind (ToM), inhibitory control, and their ability to pull a practical joke. Ninety-five children between ages 2 and 6 participated in, among other measures, a practical joke task that required them to knowingly give one of the experimenters a gift box containing a rubber insect. Results showed that children’s ability to pull a practical joke was significantly related to their age, false belief understanding (FBU), inhibitory control, and verbal ability. Children with more siblings were more likely to successfully pull a practical joke. Most importantly, inhibitory control was shown to mediate the relation between FBU and practical joking. The findings provide evidence that practical joking as an example of ToM use is effortful.
Rejection sensitivity and the development of social anxiety symptoms during adolescence: A five-year longitudinal study

Rejection sensitivity is a bias toward expecting rejection that can result from negative social experiences and degrade emotional adjustment. In this study, rejection sensitivity was expected to predict patterns of adolescent social anxiety over 5 years when considered alongside other known or expected risk and protective factors: peer rejection (peer-reported), emotion dysregulation, self-worth, temperament (parent-reported), female gender, and grade. Participants were 377 Australian students (45% boys; 79% White, 15% Asian) aged 10 to 13 years (M = 12.0, SD = .90) and their parents (84%) who completed seven repeated surveys across 5 years. In an unconditional latent growth model, social anxiety symptoms had a significant quadratic pattern of growth, with symptoms increasing about midway into the study when adolescents were age 14, on average. In a model with all predictors, rejection sensitivity was uniquely associated with a higher intercept and a more pronounced quadratic growth pattern of social anxiety symptoms. Other predictors of growth in symptoms were the temperamental trait of negativity affectivity and emotion dysregulation; negative affectivity was associated with a higher intercept and a more pronounced quadratic pattern, and emotion dysregulation was associated with a higher intercept and a less pronounced quadratic pattern. Gender was associated with the intercept, with girls higher in symptoms than boys.
The Effect of Lorentz Forces on Satellite Propagation Summary Report

All charged objects in space are effect by the Lorentz force. This project developed a Python module to simulate this effect, for use with UNSW Canberra Space’s existing propagator software. Past work in the area has been primarily analytical, considering simple models of the magnetic field and fixed satellite charges. The few works extending beyond this have only considered passive effects. The module implements a complex magnetic field model, using the IGRF’s spherical harmonic expansion. Satellite charging is simulated as either fixed, actively controlled or passively varying based on the plasma environment. The completed module was then used to investigate several potential applications of Lorentzaugmented satellites. Propellantless variation of longitude for polar orbiting satellites was successfully demonstrated, as were novel SSOs within a range of inclinations. Drag mitigation was also achieved in eccentric orbits.
Perceptions of undergraduate medical students regarding the Educational Environment: A Baseline study.

Background: Perception regarding the educational environment in an institute is related to various factors like motivation, satisfaction, and effective learning of medical students. Objective: To determine undergraduate medical students’ perceptions of 1st – final year class, regarding the educational environment in their institute. Methodology: Descriptive cross-sectional study conducted at a private Medical and Dental College in Lahore; during the time period of July 19-Oct 19. A sample of 375 was taken, equally divided among all five classes and across gender & Purposive sampling was applied. The data collection instrument was DREEM Questionnaire. Socio-demographic and variables of DREEM were included in the study. Data was analyzed on SPSS 20 planned as 1) Descriptive statistics, mean and standard deviation for all categories, frequency trends will be noted for total and subunit scores of DREEM 2) Independent sample t-test will be applied to identify gender and residential status-related difference in all subcategories and total score of DREEM 3) ANOVA will be applied to identify variation among all five classes. Results: 163 male and 203 female students participated. DREEM total mean score was 118.44±19.41, and 299(81.7%) had responded to it to be more positive than negative. Independent sample t-test found a significant P-value <0.05 with gender & residential status for total as well as subunit domains of DREEM. One-way ANOVA again showed significant P-values <0.05 for total as well as subunit domains of DREEM. Conclusion: Assessment of the educational environment should be conducted on regular basis as per policy in order to have a successful environment. This will in turn be beneficial for the students as well as the institution in a timely manner; and will definitely help in improving the teaching and learning environment in the institution by taking the necessary actions in weaker areas. Keywords: Educational environment, DREEM, undergraduate, medical student
Interactive comment on “Modelling socio-hydrological systems: a review of concepts, approaches and applications” by P. Blair and W. Buytaert

Pleased to see discussion on the differences between socio-ecology and sociohydrology, however suggests missing differences (e.g. flowing water, hydrological cycle). Suggestion of summary section focusing on these similarities and differences. I am glad that you agree that drawing on the similarities and differences between socioecology and socio-hydrology provides a useful insight, particularly at this stage in the development of socio-hydrology, where modelling studies are few. The omissions that you highlight in the differences between socio-ecology and socio-hydrology are important, and so the fact that socio-hydrology deals with flowing water and the hydrological cycle will be included in the revised version of this manuscript. As part of the restructuring which is detailed later, the suggested summary section discussing the similarities and differences between socio-ecology and socio-hydrology will be included.
Mitigation of Aspergillus flavus and its aflatoxins in wheat grains by gamma irradiation and calcium oxide

Aspergillus flavus is one of the important species of molds that can produce toxins during improper storage of wheat grains. In this study, different amounts of calcium oxide (0, 0.5, and 1%) were mixed with wheat samples containing mold spores. After 20 days, the samples were exposed to gamma radiation (0, 5, 10, 15, and 20 KGy). The presence of A. flavus, Aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1), and aflatoxin G2 (AFG2) was assessed in samples. The results indicated that the effects of calcium oxide, gamma irradiation, and their interactions were significant on A. flavus, AFB1, and AFB2 contamination. Furthermore, other toxins like AFG1 and AFG2 were not found in the samples. An additional reduction in AFB1 and AFB2 was observed when irradiation was accompanied by Cao, and the maximum inhibition of aflatoxin production was achieved at 0.5% CaO. Consequently, based on the standard maximum limit of 10 KGy for cereals, the findings of this research suggest that 0.5% of calcium oxide and 10 KGy of irradiation could be applied in the storage of wheat grains to mitigate A. flavus, AFB1, and AFB2.
A Study on the Impact of COVID- 19 on Investor Behaviour of Individuals in a Small Town in the State of Madhya Pradesh, India

Purpose: To understand how the COVID-19 pandemic has impacted investment and financial decisions of individuals in small towns in developing nations such as India. Methodology: A literature review was undertaken on COVID-19 and steps taken by the government to fight the pandemic. A sample survey was conducted to determine the impact of COVID-19 on individuals’ financial transactions in Madhya Pradesh (MP) . The respondents either belonged to the service sector or owned businesses. The relationship between the COVID-19 pandemic and change in investment decisions of individuals with respect to SIPs was studied. Findings: Significant association was found between measures taken to prevent the spread of COVID-19 (such as lockdown and travel restrictions) and individual income; such preventive measures directly impacted savings and investment behaviour. Indeed, respondents reported a 43% drop in SIP investments during the COVID-19 pandemic. While decline in investment was common to genders, the difference between percentage decline was statistically non-significant. Furthermore, investment behaviour did not vary with investor age. Research Implications: Results highlight the socioeconomic effects of the COVID-19 outbreak at the micro-level and may enable financial institutions and individuals to better handle such situations in future. The scope of the present research is limited. Future studies could consider larger samples and different contexts to gain deeper insights into the socioeconomic effects of the COVID-19 pandemic. Studies could also suggest policies and measures to help governments effectively deal with future crises. Originality/ Value: Hitherto, the impact of COVID-19 outbreak on investment decisions of individuals in Tier 3 cities had remained under-examined; this is one of the first studies to carry out such an investigation.
SENSITIVITY TO FAST AMPLITUDE RISE TIMES PREDICTS NOVEL VOCABULARY LEARNING

This study tested whether individual sensitivity to an auditory perceptual cue called amplitude rise time (ART) facilitates novel word learning. Forty adult native speakers of Polish performed a perceptual tasktestingtheir sensitivity toART,learned associations betweennonwordsandpictures This research has been funded from the National Science Centre Poland grant Individual Cognitive Abilities and Second Language Acquisition of Vocabulary [UMO-2016/20/S/HS6/00051] We thank Micha ł Remiszewski, Dominika Szczerbi n´ ska, and Emilia Ż ak for their help with EEG data collection. We also thank the anonymous reviewers for helping us improve the manuscript. TheexperimentinthisarticleearnedanOpenDatabadgefortransparentpractices.Thematerialsare available at https://osf.io/3fxgc/ of common objects, and were subsequently tested on their knowledge with a picture recognition (PR) task. In the PR task participants heard each nonword, followed either by a congruent or incongruent picture, and had to assess if the picture matched the nonword. Word learning ef ﬁ ciency was measured by accuracy and reaction time on the PR task and modulation of the N300 ERP. As predicted, participants with greater sensitivity to ART showed better performance in PR suggesting that auditory sensitivity indeed facilitates learning of novel words. Contrary to expectations, the N300 was not modulated by sensitivity to ART suggesting that the behavioral and ERP measures re ﬂ ect different underlying processes.