Miracle-dz/UniFAR-FTUs huggingface dataset:
Properties of Polymer Composites Used in High-Voltage Applications

The present review article represents a comprehensive study on polymer micro/nanocomposites that are used in high-voltage applications. Particular focus is on the structure-property relationship of composite materials used in power engineering, by exploiting fundamental theory as well as numerical/analytical models and the influence of material design on electrical, mechanical and thermal properties. In addition to describing the scientific development of micro/nanocomposites electrical features desired in power engineering, the study is mainly focused on the electrical properties of insulating materials, particularly cross-linked polyethylene (XLPE) and epoxy resins, unfilled and filled with different types of filler. Polymer micro/nanocomposites based on XLPE and epoxy resins are usually used as insulating systems for high-voltage applications, such as: cables, generators, motors, cast resin dry-type transformers, etc. Furthermore, this paper includes ample discussions regarding the advantages and disadvantages resulting in the electrical, mechanical and thermal properties by the addition of micro- and nanofillers into the base polymer. The study goals are to determine the impact of filler size, type and distribution of the particles into the polymer matrix on the electrical, mechanical and thermal properties of the polymer micro/nanocomposites compared to the neat polymer and traditionally materials used as insulation systems in high-voltage engineering. Properties such as electrical conductivity, relative permittivity, dielectric losses, partial discharges, erosion resistance, space charge behavior, electric breakdown, tracking and electrical tree resistance, thermal conductivity, tensile strength and modulus, elongation at break of micro- and nanocomposites based on epoxy resin and XLPE are analyzed. Finally, it was concluded that the use of polymer micro/nanocomposites in electrical engineering is very promising and further research work must be accomplished in order to diversify the polymer composites matrices and to improve their properties.
Modeling Biobehavioral Rhythms with Passive Sensing in the Wild

Biobehavioral rhythms are associated with numerous health and life outcomes. We study the feasibility of detecting rhythms in data that is passively collected from Fitbit devices and using the obtained model parameters to predict readmission risk after pancreatic surgery. We analyze data from 49 patients who were tracked before surgery, in hospital, and after discharge. Our analysis produces a model of individual patients' rhythms for each stage of treatment that is predictive of readmission. All of the rhythm-based models outperform the traditional approaches to readmission risk stratification that uses administrative data.
Intestinal microbiota of broilers submitted to feeding restriction and its relationship to hepatic metabolism and fat mass: Fast-growing strain.

The present study was conducted to verify how feed restriction affects gut microbiota and gene hepatic expression in broiler chickens and how these variables are related to body weight gain. For the experiment, 21-d-old Cobb500TM birds were distributed in a completely randomized experimental design with three treatments: T1. Control (ad libitum-3.176 Mcal/kg ME-metabolizable energy-and 19% CP-crude protein); T2. Energetic restriction (2.224 Mcal/kg ME and 19% CP) from 22 to 42 days with consumption equivalent to control; T3. Quantitative restriction (70% restriction, i.e., restricted broilers ingested only 30% of the quantity consumed by the control group-3.176 Mcal/kg ME and 19% CP) for 7 days, followed by refeeding ad libitum from 28 to 42 days. Ileum and caecum microbiota collections were made at 21, 28 and 42 days of age. Hepatic tissue was collected at 28 and 42 days old for relative gene expression analyses. At 43-d-old, body composition was quantified by DXA (Dual-energy X-ray Absorptiometry). Both feed restriction programmes decreased Lactobacillus and increased Enterococcus and Enterobacteriaceae counts. No differences were found in the refeeding period. Energetic restriction induced the expression of CPT1-A (Carnitine palmitoyltransferase 1A) gene, and decreased body fat mass. Quantitative feed restriction increased lipogenic and decreased lipolytic gene expression. In the refeeding period, CPT1-A gene expression was induced, without changing the broilers body composition. Positive associations were found between BWG (Body Weight Gain) and Lactobacillus and Clostridium cluster IV groups, and negatively associations with Enterobacteriaceae and Enterococcus bacterial groups. In conclusion, differences found in microbiota were similar between the two feed restriction programmes, however, hepatic gene expression differences were only found in quantitative restriction. Higher counts of Lactobacillus and Clostridium cluster IV groups in ileum are likely to be related to better broiler performance and low expression of lipogenic genes.
Evolution of Fracture Aperture in Quartz Sandstone under Hydrothermal Conditions: Mechanical and Chemical Effects

Fractures efficiently affect fluid flow in geological formations, and thereby determine mass and energy transport in reservoirs, which are not least exploited for economic resources. In this context, their response to mechanical and thermal changes, as well as fluid–rock interactions, is of paramount importance. In this study, a two-stage flow-through experiment was conducted on a pure quartz sandstone core of low matrix permeability, containing one single macroscopic tensile fracture. In the first short-term stage, the effects of mechanical and hydraulic aperture on pressure and temperature cycles were investigated. The purpose of the subsequent intermittent-flow long-term (140 days) stage was to constrain the evolution of the geometrical and hydraulic fracture properties resulting from pressure solution. Deionized water was used as the pore fluid, and permeability, as well as the effluent Si concentrations, were systematically measured. Overall, hydraulic aperture was shown to be significantly less affected by pressure, temperature and time, in comparison to mechanical aperture. During the long-term part of the experiment at 140 °C, the effluent Si concentrations likely reached a chemical equilibrium state within less than 8 days of stagnant flow, and exceeded the corresponding hydrostatic quartz solubility at this temperature. This implies that the pressure solution was active at the contacting fracture asperities, both at 140 °C and after cooling to 33 °C. The higher temperature yielded a higher dissolution rate and, consequently, a faster attainment of chemical equilibrium within the contact fluid. X-ray µCT observations evidenced a noticeable increase in fracture contact area ratio, which, in combination with theoretical considerations, implies a significant decrease in mechanical aperture. In contrast, the sample permeability, and thus the hydraulic fracture aperture, virtually did not vary. In conclusion, pressure solution-induced fracture aperture changes are affected by the degree of time-dependent variations in pore fluid composition. In contrast to the present case of a quasi-closed system with mostly stagnant flow, in an open system with continuous once-through fluid flow, the activity of the pressure solution may be amplified due to the persistent fluid-chemical nonequilibrium state, thus possibly enhancing aperture and fracture permeability changes.
Risk factors for violence in transgender people: a retrospective study of experiences during adolescence

ABSTRACT Background: Transgender people are often victims of multiple types of violence across several areas of life due to society’s marked intolerance of gender nonconformity. Objective: This study seeks to describe experiences of violence in transgender individuals and explore the relationship between different types of violence and specific, high-risk gender incongruence and social rejection factors during adolescence. Method: The sample consisted of 245 transgender adults receiving transgender-related health services at a public specialised clinic in Mexico City. Results: Findings are in line with the evidence in the literature and confirm that transgender people are at a high risk of different types of violence, with psychological violence being the most common, followed by physical and sexual violence. This occurs at an early age and in different contexts, mainly through social experiences with family members and school peers. Experiences of rejection, seeking to be treated as the gender identity and asking to be called by the name selected for gender identity were the most important predictors for all types of violence. Conclusion: This study highlights the need for interventions to prevent violence against transgender youth from an early age to provide safe family and school environments for their healthy development.
Patch Matching and Dense CRF-Based Co-Refinement for Building Change Detection from Bi-Temporal Aerial Images

The identification and monitoring of buildings from remotely sensed imagery are of considerable value for urbanization monitoring. Two outstanding issues in the detection of changes in buildings with composite structures and relief displacements are heterogeneous appearances and positional inconsistencies. In this paper, a novel patch-based matching approach is developed using densely connected conditional random field (CRF) optimization to detect building changes from bi-temporal aerial images. First, the bi-temporal aerial images are combined to obtain change information using an object-oriented technique, and then semantic segmentation based on a deep convolutional neural network is used to extract building areas. With the change information and extracted buildings, a graph-cuts-based segmentation algorithm is applied to generate the bi-temporal changed building proposals. Next, in the bi-temporal changed building proposals, corner and edge information are integrated for feature detection through a phase congruency (PC) model, and the structural feature descriptor, called the histogram of orientated PC, is used to perform patch-based roof matching. We determined the final change in buildings by gathering matched roof and bi-temporal changed building proposals using co-refinement based on CRF, which were further classified as “newly built,” “demolished”, or “changed”. Experiments were conducted with two typical datasets covering complex urban scenes with diverse building types. The results confirm the effectiveness and generality of the proposed algorithm, with more than 85% and 90% in overall accuracy and completeness, respectively.
Information Circulation in The Advanced Neural Activities of Central Neural System

Long-Term Potentiation(LTP) and Long-Term Depression(LTD) are two major forms of synaptic plasticity, which are also two well-know functional and unit activities involved in high advanced central neural system(CNS) activities, like memory. But we still know little about how the advanced CNS activities are organized in the brain and in the level of organism. Based on the current understanding and experimental evidence of neurology, we propose the term “Information Circulation” to summarize the current understandings for advanced CNS activities, and we define it as separately input neural signals finally converge in different levels of CNS and interact with each other, then neural information are circulated and processed in different levels of CNS to give out orders for next body actions. This review provides a detailed description for the functional organizations of advanced CNS activities in the term of Information Circulation. This article outlines the receiving of outside stimulation and transmission of neural information, especially transmission and procession of visual bioelectrical signals, then we described neural circuits of Information Circulation in advanced CNS activities, the corresponding specificity and dynamic properties of neural circuits, different sensation linkages, and neural synchronization for information circulation to produce consciousness in CNS. In conclusion, Information Circulation is defined as an important signature involved in advanced CNS activities.
PM2.5 Pollution and Inhibitory Effects on Industry Development: A Bidirectional Correlation Effect Mechanism

In this paper, a vector autoregression (VAR) model has been constructed in order to analyze a two-way mechanism between PM2.5 pollution and industry development in Beijing via the combination of an impulse response function and variance decomposition. According to the results, long-term equilibrium interconnection was found between PM2.5 pollution and the development of primary, secondary, and tertiary industries. One-way Granger causalities were found in the three types of industries shown to contribute to PM2.5 pollution, though the three industries showed different scales of influences on the PM2.5 pollution that varied for about 1–2 years. The development of the primary and secondary industries increased the emission of PM2.5, but the tertiary industry had an inhibitory effect. In addition, PM2.5 pollution had a certain inhibitory effect on the development of the primary and secondary industries, but the inhibition of the tertiary industry was not significant. Therefore, the development of the tertiary industry can contribute the most to the reduction of PM2.5 pollution. Based on these findings, policy-making recommendations can be proposed regarding upcoming pollution prevention strategies.
Differential Effects of Yeast NADH Dehydrogenase (Ndi1) Expression on Mitochondrial Function and Inclusion Formation in a Cell Culture Model of Sporadic Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder that exhibits aberrant protein aggregation and mitochondrial dysfunction. Ndi1, the yeast mitochondrial NADH dehydrogenase (complex I) enzyme, is a single subunit, internal matrix-facing protein. Previous studies have shown that Ndi1 expression leads to improved mitochondrial function in models of complex I-mediated mitochondrial dysfunction. The trans-mitochondrial cybrid cell model of PD was created by fusing mitochondrial DNA-depleted SH-SY5Y cells with platelets from a sporadic PD patient. PD cybrid cells reproduce the mitochondrial dysfunction observed in a patient’s brain and periphery and form intracellular, cybrid Lewy bodies comparable to Lewy bodies in PD brain. To improve mitochondrial function and alter the formation of protein aggregates, Ndi1 was expressed in PD cybrid cells and parent SH-SY5Y cells. We observed a dramatic increase in mitochondrial respiration, increased mitochondrial gene expression, and increased PGC-1α gene expression in PD cybrid cells expressing Ndi1. Total cellular aggregated protein content was decreased but Ndi1 expression was insufficient to prevent cybrid Lewy body formation. Ndi1 expression leads to improved mitochondrial function and biogenesis signaling, both processes that could improve neuron survival during disease. However, other aspects of PD pathology such as cybrid Lewy body formation were not reduced. Consequently, resolution of mitochondrial dysfunction alone may not be sufficient to overcome other aspects of PD-related cellular pathology.
Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis

Chemotherapy and/or head and neck radiotherapy are frequently associated with oral mucositis. Oral pain, odynophagia and dysphagia, opioid use, weight loss, dehydration, systemic infection, hospitalization and introduction of a feeding tube should be mentioned as the main determinated effect of oral mucositis. Oral mucositis leads to a decreased quality of life and an increase in treatment costs. Moreover, oral mucositis is a life-threatening disease. In addition to its own direct life-threatening consequences, it can also lead to a reduced survival due to the discontinuation or dose reduction of anti-neoplasm therapy. There are numerous strategies for the prevention or treatment of oral mucositis; however, their effectiveness is limited and does not correspond to expectations. This review is focused on the ghrelin and obestatin as potentially useful candidates for the prevention and treatment of chemo- or/and radiotherapy-induced oral mucositis.
Increased Expression of Vascular Endothelial Growth Factor-D Following Brain Injury

Alterations in the expression of the vascular endothelial growth factors (VEGF) A and B occur during blood–brain barrier (BBB) breakdown and angiogenesis following brain injury. In this study, the temporal and spatial expression of VEGF-D and VEGF receptors-2 and -3 (VEGFR-2 and VEGFR-3, respectively) was determined at the mRNA and protein level in the rat cortical cold-injury model over a period of 0.5 to 6 days post-injury. In order to relate endothelial VEGF-D protein expression with BBB breakdown, dual labeling immunofluorescence was performed using antibodies to VEGF-D and to fibronectin, a marker of BBB breakdown. In control rats, VEGF-D signal was only observed in scattered perivascular macrophages in the cerebral cortex. The upregulation of VEGF-D mRNA expression was observed in the injury site between days 0.5 to 4, coinciding with the period of BBB breakdown and angiogenesis. At the protein level, intracerebral vessels with BBB breakdown to fibronectin in the lesion on days 0.5 to 4 failed to show endothelial VEGF-D. Between days 0.5 to 6, an increased VEGF-D immunoreactivity was noted in the endothelium of pial vessels overlying the lesion site, in neutrophils, macrophages, and free endothelial cells within the lesion. The upregulation of VEGFR-2 and -3 mRNA and protein expression was observed early post-injury on day 0.5. Although there was concurrent expression of VEGF-A, VEGF-B, and VEGF-D post-injury, differences in their spatial expression during BBB breakdown and angiogenesis suggest that they have specific and separate roles in these processes.
Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

Thymidylate synthase (TS) is an enzyme of paramount importance as it provides the only de novo source of deoxy-thymidine monophosphate (dTMP). dTMP, essential for DNA synthesis, is produced by the TS-catalyzed reductive methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) using N5,N10-methylenetetrahydrofolate (mTHF) as a cofactor. TS is ubiquitous and a validated drug target. TS enzymes from different organisms differ in sequence and structure, but are all obligate homodimers. The structural and mechanistic differences between the human and bacterial enzymes are exploitable to obtain selective inhibitors of bacterial TSs that can enrich the currently available therapeutic tools against bacterial infections. Enterococcus faecalis is a pathogen fully dependent on TS for dTMP synthesis. In this study, we present four new crystal structures of Enterococcus faecalis and human TSs in complex with either the substrate dUMP or the inhibitor FdUMP. The results provide new clues about the half-site reactivity of Enterococcus faecalis TS and the mechanisms underlying the conformational changes occurring in the two enzymes. We also identify relevant differences in cofactor and inhibitor binding between Enterococcus faecalis and human TS that can guide the design of selective inhibitors against bacterial TSs.
Fate of Ergot Alkaloids during Laboratory Scale Durum Processing and Pasta Production

The fate of ergot alkaloids during the milling of durum and subsequent production and cooking of pasta was examined. Durum samples containing varying amounts of ergot sclerotia (0.01–0.1% by mass) were milled, and all milling product was analyzed for 10 ergot alkaloids using liquid chromatography with tandem mass spectrometry. Spaghetti was prepared from the semolina obtained during milling. Ergocristine, ergocristinine, and ergotamine were the predominant ergot alkaloids observed in the milling fractions and spaghetti. Approximately 84% of the total ergot alkaloid mass of the whole grain durum resided in the milling product fractions associated with the outer kernel layers (bran, shorts, feeds). No consistent loss of ergot alkaloids was observed during the production or cooking of spaghetti. However, changes in the ratio of R- to S-enantiomers occurred during the milling and cooking of spaghetti. Products containing bran, shorts, and feeds, as well as cooked spaghetti, contained a higher proportion of the less biologically active S-enantiomers. The results of this study emphasize the need to monitor R- and S-enantiomers, and to consider food and feed products, as opposed to whole grain, when assessing any exposure of consumers to ergot alkaloids.
Cleaning Staff’s Attitudes about Hand Hygiene in a Metropolitan Hospital in Australia: A Qualitative Study

Background: In 2009, the National Hand Hygiene Initiative (NHHI) was implemented in hospitals across Australia with the aim of improving hand hygiene practices and reducing healthcare-associated infections. Audits conducted post-implementation showed the lowest rates of compliance with hand hygiene practices are among operational staff including hospital cleaners. There is limited information about hand hygiene issues in hospital cleaners to inform development of evidence-based interventions to improve hand hygiene compliance in this group. Aim: This qualitative study was undertaken to explore the attitudes of hospital cleaning staff regarding hand hygiene and the National Hand Hygiene Initiative. Methodology: Focus groups were conducted with 12 cleaning staff at a large Australian hospital implementing the National Hand Hygiene Initiative. Findings: Hospital cleaners recognise the importance of hand hygiene in preventing healthcare-associated infections. Cleaners cite peer support, leadership, and the recognition and reward of those excelling in hand hygiene as strong motivators. Barriers to optimal hand hygiene practice include the presence of multiple conflicting guidelines, hand hygiene “overload” and a lack of contextualised education programs. This exploratory qualitative study reveals three themes about attitudes of hospital cleaning staff towards hand hygiene. These themes are: (1) “The culture of hand hygiene: It’s drummed into us”; (2) “Reminders and promotion for hand hygiene: We just need a big ‘Please wash your hands’ sign”; and (3) “The personal value of hand hygiene: Like he said, it’s second nature to us”. Conclusion: Hand-hygiene messages and training need to be more consistent and contextualised to achieve improvements in hand hygiene practices in hospital cleaning staff in Australia.