Benign course of SARS‐CoV‐2 infection in a series of pediatric oncology patients

To the Editor: Limited studies have shown that patients with cancer infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have more severe disease than the general population, with higher rates of serious illness and death in this population1-3 and other immunocompromised populations.4,5 Children are susceptible to SARS-CoV-2 infection, but clinical severity of the infection is significantly less than in adults.6,7 However, there is a paucity of data describing SARS-CoV-2 infection in pediatric patients with cancer. Here we report our experience with six pediatric oncology patients at our institution who tested positive for SARS-CoV-2 infection. Patients were tested for SARS-CoV-2 infection either for clinical suspicion of infection or as part of a hospital surveillance program testing all admitted patients and patients undergoing procedures.Nasopharyngeal swab sampleswereanalyzed in aCLIA-certified laboratory using an FDA emergency authorization use (EUA) PCR assay (Abbott Realtime SARS-CoV-2, m2000 instrument). Amplification cycle threshold (Ct) values were recorded from the assay results, with lower values indicating higher amounts of viral nucleic acid. Table 1 summarizes patient characteristics, SARS-CoV-2 testing results, and clinical courses of the six pediatric oncology patients identifiedwith SARS-CoV-2 infection at our institution. All of these patients had relatively mild SARS-CoV-2-related symptoms. None were hospitalized specifically due to SARS-CoV-2-related symptoms, and none required any respiratory support at diagnosis. Further details on the clinical courses of two high-risk leukemia patients are summarized below. Patient 1 is a 5-year-old male 5 months post-allogeneic stem cell transplant for high-risk acute myeloid leukemia on maintenance midostaurin. His posttransplant course was complicated by graftversus-host disease, sinusoidal obstructive syndrome, and idiopathic pneumonia syndrome.He presented to a routine clinic visit with cough. A respiratory viral panel and SARS-CoV-2 testing were both negative. The next day, he had a fever and required aggressive fluid resuscitation after becoming hypotensive with antibiotic administration, and subsequently developed respiratory distress necessitating high-flow nasal cannula oxygen. Repeat SARS-CoV-2 testing the next day was again negative, and blood cultures grew both Acinetobacter junii and Pseudomonas aeruginosa. He clinically improved over the next few days and was off supplemental oxygen within 4 days without any further respiratory symptoms. SARS-CoV-2 testing was repeated in advance of a scheduled procedure and was positive. He continued to do well and was discharged 3 days later after completing antibiotics. Repeat testing 2weeks later was negative. Patient 2 is a 6-year-old male with recently relapsed T-cell acute lymphoblastic leukemia undergoing reinduction chemotherapy. He presented to the oncology clinic for chemotherapy with cough and rhinorrhea, but was afebrile and otherwise well. Over the next 2 weeks, he had gradual improvement in his respiratory symptoms. It was then discovered that he had been exposed to SARS-CoV-2, 5 days prior to symptom onset. He presented 2 weeks later for another cycle of chemotherapy, at which time he tested positive. He tested positive again on day 8, and then 2 days later was admitted with fever and neutropenia without worsening cough or rhinorrhea. He had an uncomplicated hospital course, but still tested positive for SARS-CoV-2 on the day of discharge and again 5 days later. Repeat testing after another 10 days, 6 weeks after symptom onset, was negative. Although children have milder SARS-CoV-2 infections, there is a natural concern that children with cancer are at higher risk of severe illness from SARS-CoV-2 infection and that further immunosuppressive cancer-related treatment may increase this risk, as has been reported in adults with cancer.1-3 We found that our cancer patients with SARS-CoV-2 infections had generally mild, self-limited courses without need for any respiratory support, similar to the presentation of SARS-CoV-2 infection in the general pediatric population.6,7 Two of the three patients requiring hospital admission were for reasons unrelated to SARS-CoV-2 infection and the respiratory symptoms of the third patient that required ICU-level care was in the setting of preexisting lung pathology from posttransplant complications, and seemed to be related to polymicrobial sepsis, given his rapid improvement with antibiotics and diuresis. Additionally, two of our patients (numbers 2 and 4 in Table 1) received further chemotherapy without clearance of SARS-CoV-2 infection. Although both experienced an increase in the level of SARS-CoV-2 RNAdetected (based on decreasing Ct value), this was likely related to chemotherapy-induced lymphopenia and did not correlate with anyworsening of symptoms. Our series of pediatric oncology patients with relatively benign courses of SARS-CoV-2 infection is consistent with reports from both Italy and New York city, where five and 20 pediatric cancer patients, respectively, were identified as having mild or asymptomatic SARS-CoV-2 infection,8,9 and mirror the experience in some patients on biologics for immune-mediated inflammatory disease.10 Given the inherently aggressive nature of many childhood cancers, significant treatment delays can increase the risk of disease progression. While