Miracle-dz/UniFAR-FTUs huggingface dataset:
Expansion, persistence and efficacy of donor memory-like NK cells for the treatment of post-transplant relapse

Background. Responses to conventional donor lymphocyte infusion (DLI) for post-allogeneic hematopoietic cell transplantation (HCT) relapse are typically poor. Natural killer (NK) cell-based therapy is a promising modality to treat post-HCT relapse. Methods. We initiated this ongoing phase 1 trial of adoptively transferred cytokine induced memory-like (CIML) NK cells in patients with myeloid malignancies relapsed after haploidentical HCT. All patients received a donor-derived NK cell dose of 5-10 million cells/kg after lymphodepleting chemotherapy, followed by systemic IL-2 for 7 doses. High resolution profiling with mass cytometry and single cell RNA sequencing characterized the expanding and persistent NK cells subpopulations in a longitudinal manner after infusion. In vitro functional studies of infused CIML NK cells were complemented with in vivo evaluation of NK trafficking to disease sites using multiparameter immunofluorescence. Results. In the first 5 patients on the trial, infusion of CIML NK cells led to a rapid 10 to 50-fold in vivo expansion that was sustained over months. The infusion was well-tolerated, with fever and pancytopenia as the most common adverse events. Responses were attained in 4 of 5 patients at day +28. Immunophenotypic and transcriptional profiling revealed a dynamic evolution of the activated CIML NK cell phenotype, superimposed on the natural variation in donor NK cell repertoires. AML relapse after initial response to CIML NK cell therapy was associated with low transcript expression of CD2 ligands, including CD48/SLAMF2 and CD58/LFA3. Conclusion. Given their rapid expansion and long-term persistence, CIML NK cells serve as a promising platform for the treatment of post-transplant relapse of myeloid disease. Further characterization of their unique in vivo biology and interaction with both T-cells and tumor targets will lead to the development of novel cell-based immunotherapies.
ORACLES, as well as CLAIPSO and CloudSat, to identify and quantify mid-level clouds off the coast of South Africa. Although low-level clouds (stratocumulus) in this region have received

10 Shortwave-absorbing aerosols seasonally overlay extensive low-level stratocumulus clouds over the southeast Atlantic. While much attention has focused on the interactions between the low-level clouds and the overlying aerosols, few studies have focused on the mid-level clouds that also occur over the region. The presence of mid-level clouds over the region complicates the space-based remote-sensing retrievals of cloud properties and the evaluation of cloud radiation budgets. Here we characterize the mid-level clouds over the southeast Atlantic using lidarand radar-based 15 satellite cloud retrievals and observations collected in September 2016 during the ORACLES (ObseRvations of Aerosols above CLouds and their intEractionS) field campaign. We find that mid-level clouds over the southeast Atlantic are relatively common, with the majority of the clouds occurring between altitudes of 5 and 7 km, at temperatures between 0 and -20 oC. The mid-level clouds occur at the top of a moist mid-tropospheric smoke aerosol layer, most frequently between August and October, and closer to the southern African coast than farther offshore, and 20 they occur more frequently during the night than during the day. Between July and October, approximately 64% of the mid-level clouds have a geometric cloud thickness less than 1 km, corresponding to a cloud optical depth of less than 4. A lidar-based depolarization-backscatter relationship for September 2016 indicates that the mid-level clouds are liquid-only clouds with no evidence of the existence of ice. In addition, a polarimeter-derived cloud droplet size distribution indicates that approximately 85 % of the September-2016 mid-level clouds have an effective radius less 25 than 7 μm, which could further discourage the ability of the clouds to glaciate. These clouds are mostly associated with synoptically-modulated mid-tropospheric moisture outflow that can be linked to the detrainment from the continentalbased clouds. Overall, the supercooled mid-level clouds reduce the radiative cooling rates of the underlying lowaltitude cloud tops by approximately 10 K/day, thus influencing the regional cloud radiative budget. 30
Experimental study on the ozone absorption accompanied by instantaneous chemical reaction

ABSTRACT This work deals with gas absorption accompanied by chemical reaction in a liquid phase. Ozone absorption in potassium indigotrisulfonate solution was investigated in a batch bubble column. Enhancement factor for absorption accompanied by instantaneous chemical reaction in the liquid phase was experimentally determined, as a ratio of the volumetric mass transfer coefficient for the absorption accompanied by reaction to that for pure physical absorption. The influence of (a) the initial concentration of the solute from liquid phase and (b) the ozone concentration in gas phase on the enhancement factor were experimentally examined. The absorption accompanied by instantaneous chemical reaction is a diffusion-controlled process, whose rate depends upon the diffusivities of the absorbing gas and the solute in liquid phase. The influence of these diffusivities was found to be more significant for lower values of the enhancement factor. The rate of ozone absorption was followed by the time change of the solution color, using new method based on the computer program SigmaScan Pro 5 (Systat Software, Inc., San Jose, CA, USA). This investigation is a contribution to the prediction of the ozone consumption in wastewater treatment, in cases when ozone instantaneously reacts with substances present in water.
Organochlorine pesticides removal from groundwater by citrus coal and UV/O3: a hybrid pilot-scale study

In this laboratory-scale study, organochlorine pesticides (OCPs) reduction using citrus coals and O3 assisted by solar UV as an integrated treatment of groundwater under visible UV to reach sustainable development were traced. The experimental parameters were set up throughout standard methods and analysis protocols. The best performance of citrus coal was observed at a reaction time of 90 min, pH: 6.5, adsorption bed height = 40 cm, initial OCPs concentration, respectively, as 100 μg/L for alachlor (ALC), α (±)-BHC, atrazine (ATZ), and α-chlordane, 150 μg/L for methoxychlor, 50 μg/L for heptachlor, and 90 μg/L for dieldrin. The best performance of citrus coal was observed at a reaction time of 90 min, pH: 6.5, adsorption bed height 40 cm, initial OCPs concentration of 100 μg/L for ALC, α (±)-BHC, ATZ, and α-chlordane, 150 μg/L for methoxychlor, 50 μg/L for heptachlor, and 90 μg/L for dieldrin. Under the above-mentioned operating conditions, the removal rates were estimated at more than 75% for all these compounds. The adsorption outputs were fitted to the Freundlich model with the average R2 > 0.97, while for the Langmuir model this value was >0.86. Thereby, it is concluded that OCPs adsorption occurs on a heterogeneous surface by multilayer sorption. With regard to Kf(1/n) parameter, for the Freundlich adsorption model, the order of OCPs adsorption was appeared to be methoxychlor > dieldrin > heptachlor > α-chlordane > ALC > α (±)-BHC > ATZ. The optimum variables for UV/O3 were obtained as 0.4 mg/L ozone, pH = 9, and 35 min reaction time, so that, more than 98% of these substances were degraded from the solution under this condition. The reaction kinetics were fitted with R2 value of more than 0.9 for most OCPs. The kinetic reaction constants (k) in pH values of 7 and 9.5 were higher than other ranges for all OCPs. The progress of pH at the alkaline area improved the pseudo-first-order constants. The kinetic model indicated that the reaction rates will be restricted by the initial pH value and the concentration of OH•. This evidence was well-established by monitoring dissolved O2 at the various pH ranges during the experiment runs. Eight intermediates were detected by gas chromatography-tandem mass spectrometry detection with chemical formula as C14H20ClNO3, C13H16ClNO3, C14H18ClNO4, –NHCH(CH3)2, –NHCOCH3, –NH2, C13H9ClO, and C7H5ClO from the samples taken in the non-optimized UV/O3 effluent. However, all of them disappeared in the final effluent at the optimized condition. Altogether, this integrated strategy helped to remove OCPs more than 86% on average, with residues less than 1 μg/L and even 0.05 μg/L in some cases. Due to the generation of a large amount of citrus wastes (46,000 ton/y) in the north of Iran and the abundance of solar energy especially solar UV in the middle east, this hybrid approach to treat groundwater contaminated with agricultural OCPs as a type of EDCs can be an effective alternative for conventional and current removal strategies to provide safety and treat groundwater by this agricultural compound.
Eudaimonia Involves Complexity: Ego Development And Eudaimonic Functioning

Eudaimonia is theorized to be a more complex type of positive functioning than hedonia, associated with personality development and maturity. In this study, we aimed to find out whether ego development (ED), proposed as a measure of psychosocial maturity, is related to eudaimonic well-being and whether trait indicators of eudaimonic functioning can explain this association. Adult participants from a community sample (N = 357, age 18-80, 63% female) completed Russian versions of WUSCT, MLQ, HEMA-R, and MHC-SF. The results of structural equation modeling indicate that trait indicators of eudaimonic functioning can explain the association between ED and eudaimonic well-being, providing some support for the view of eudaimonia as a complex type of flourishing more easily attained by mature personalities.
The Window of Entrepreneurial Opportunity: Investigation of the Antecedents of Opportunity Recognition

This paper investigates traits and capabilities affecting an individual’s opportunity recognition. We propose three categories of individual antecedents: entrepreneurial self-efficacy, problem-solving ability, and entrepreneurial imaginativeness. Using a dataset of more than 300 students, we examine correlations between these latent constructs as well as heterogeneity across observable student characteristics. Our findings indicate that students’ perceived entrepreneurial self-efficacy and entrepreneurial imaginativeness promote opportunity recognition. Moreover, the three antecedents show positive correlations among one another. Regarding socio-demographic characteristics, our results show that opportunity recognition is significantly lower among female students and those who did not attend entrepreneurship courses. The article ends with presenting the conclusions of the results, an overview of research limitations, and insights into future research.
The Investment Side of College Savings

This paper studies how households make portfolio allocation decisions to save for children's college, and how these decisions affect children's college enrollment and student debt. I first document that more than 85% of households allocate college savings to risky assets, in particular more than 60% to stocks. I also demonstrate that college savings motives explain approximately one-third of stock market participation probability outside of retirement accounts for households with children. My results show that the allocation of college savings to stocks is associated with higher children's college enrollment rates and lower student loan participation rates after controlling for family and student characteristics. Exploiting exogenous variation in the portfolio allocation of 529 accounts, I find that holding a 10% greater share of 529 accounts in stocks during the school years increases the accumulated amount of college savings up to 20% and leads to a higher probability of enrollment in a selective four-year college and a lower student loan participation for 529 account beneficiaries from middle- and high-income households.
Study of the Thermal Performance of Bio-Sourced Materials Used as Thermal Insulation in Buildings under Humid Tropical Climate

In the fight against climate change, the energy consuming building sector must also be taken into account to solve this problem. In this case thermal insulation of buildings using bio-based materials is an interesting solution. Therefore, the thermal performance of some materials of this type has been studied. The advantages of these natural materials of plant origin are multiple, biodegradable, low economic cost, renewable and readily available. The use of biobased materials is widespread in the building sector in order to replace conventional insulation materials with natural materials. Vegetable fibers are very important because they have good thermal behaviour and good insulating properties. The aim of using bio-sourced materials is in line with the logic of energy control and environmental protection, the approach is to make the inhabitants of the houses comfortable and reduce their energy consumption (energy efficiency). In this research we will present the results of studies carried out on the thermal conductivity of banana leaves, latan leaves, vetivers fibers, palm kernel fibers, sargassum, coconut leaves, sawdust and bulk sugarcane leaves. The study on thermal conductivity was carried out in two ways, on the one hand using the flash method, and on the other hand a so-called hot box experiment was carried out. We will discuss and highlight a number of influential factors such as moisture and air pockets present in the samples on the thermophysical properties of these materials, in particular thermal conductivity. Finally, the result of a thermal performance test of banana leaves on a roof in Haiti will also be presented in this work. Keywords—Buildings, insulating properties, natural materials of plant origin, thermal performance.
An observational study of clinical presentation of covid 19 among children in India

Objective: To assess the clinical presentation of COVID-19 among pediatric population in India. Methods: Study included children of age group (1 month to 14 years) with positive nasopharyngeal swab for SARS-CoV-2 done by RT-PCR presenting between 1st March 2020-31st May 2021. Their clinical and laboratory results data were analyzed. Results: 400 Children with median age of 7(1-14 years) were included. Of those 215 were asymptomatic, 127 had mild infection, 12 had moderate disease and 3 had severe disease. 43 children presented with signs of MIS-C. There was no mortality. Conclusion: Most of the COVID-19 affected children are asymptomatic. Among children with symptoms, very few have manifestations of severe disease.
A Compact Nonuniform Composite Right/Left-Handed Leaky-Wave Scanning Antenna with Elliptical Polarization for X-Band Application

A new compact nonuniform leaky-wave antenna (LWA) with left-handed elliptical polarization (LHEP), based on composite right/left-handed (CRLH) metamaterial operating in the range of 7–10.2 GHz is presented in the work. The nonuniform structure of a CRLH transmission line (TL) is realized by the placement of different configurations of inter-digital capacitor (IDC) in the form of sinusoid (SIN-IDC), on the top of metal wall of a half-mode substrate integrated waveguide (HMSIW). Balanced condition of the unit cells is provided by the change in slit width, amplitude, and the number of SIN-IDC periods, as well as by relocation of two additional transition apertures arranged by both sides of SIN-IDC. Based on the known Hensen-Woodyard criterion, the optimal number of the unit cells was determined, when the gain coefficient varied from 7.5 to 9.8 dB in all of the operational range of antenna. The developed prototype of nonuniform CRLH LWA has the size of 8.1 × 115.2 mm. It is characterized by a continuous scan angle range equal to 117◦. The maximum angle of rotation radiation pattern is −66◦ for backward radiation and +51◦ for direct radiation. The maximum efficiency of the antenna radiation is 85%, while the total one is 68%.
NDT_A_277490 19..32

1Department of Pediatrics, Skaraborgs Hospital, Skövde, Sweden; Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; 2Psychiatry Department, Clinic for Neurology and Psychiatry for Children and Youth, Belgrade, Serbia; 3Research & Development Centre, Skaraborgs Hospital, Skövde, Sweden; 4Department of Psychology, Faculty of Humanity and Social Sciences, University of Rijeka, Rijeka, Croatia; 5Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden Introduction: The Quantified behavior Test (QbTest), which combines a continuous performance task (CPT) and motion tracking, provides data for the core signs of attentiondeficit/hyperactivity disorder (ADHD): attention, hyperactivity, and impulsivity. This study aimed to evaluate the performance of children and adolescents with ADHD on the QbTest before and after a single methylphenidate (MPH) dose. Subjects and Methods: This retrospective chart review study included data from 149 children and 215 adolescents who completed the QbTest. A summary index of the CPT and motion capture data on the QbTest is provided by three cardinal parameters: QbActivity, QbImpulsivity, and QbInattention. The test was performed twice on the same day, before and up to three hours after MPH intake. A decrease by ≥ 0.5 in a cardinal parameter score was considered an improvement, whereas an increase by ≥ 0.5 a deterioration. Results: QbActivity improvement after MPH intake was present in 71.7% and 76.2% of the children and adolescents, respectively. QbImpulsivity improvement was observed in 50.4% of the children and 44.7% of the adolescents, and QbInattention improvement in 85.1% and 91.1% of the children and adolescents, respectively. All three parameters improved simultaneously in 27.7% of the children and 28.7% of the adolescents. The likelihood that one parameter deteriorated after MPH use was greater if that parameter was within the normal range before medication. This was most pronounced for QbImpulsivity. Among male adolescents, QbInattention improvement was often accompanied by QbImpulsivity deterioration. Conclusion: The QbTest inattention and motor activity parameters improved markedly after a single MPH dose in children and adolescents with ADHD, while less so for impulsivity. Improvement of one parameter is not necessarily associated with improvement of the other two, and deterioration, especially regarding impulsivity, may occur. If confirmed, these results highlight the need for optimization and individualization of MPH treatment, while monitoring all aspects of the ADHD symptomatology based on the QbTest performance.
Experimental study of heat transfer performance of horizontal-tube falling film evaporator

In this study, an experiment was conducted to analyze the heat transfer performance of a horizontal-tube falling film evaporator. The evaporator performance was tested with water and sodium chloride brine. The heat transfer performance of the crest and column sections for liquid film flow outside the tubes in a columnar flow pattern was investigated. The effects of the flow rate, tube spacing, outer tube diameter, feed temperature, and salinity on the local heat transfer coefficient outside the titanium-made heat exchange tube were studied. According to the findings of this study, (i) the local heat transfer coefficient of the crest section increases with flow rate and feed temperature, decreases with tube spacing and salinity, (ii) the local heat transfer coefficient of the column section increases with an increase in the flow rate, tube spacing, feed temperature, but decreases with salinity, and (iii) the influence of outer tube diameter on the local heat transfer coefficient of the crest and column sections varies with the circumferential angle. However, when D2 = 19 mm, the variation in the local heat transfer coefficient is not consistent with that of other horizontal tubes because of D2 < D1. In a columnar flow pattern, the crest and column formed by the flow outside the liquid film tube are two important fluctuation areas of the liquid film. In this paper, the local heat transfer coefficient of the crest and column is obtained through the experiment, which provides the foundation for improving the heat transfer performance of the horizontal-tube falling film evaporator.
Classifying strength exercises performed by wheelchair users using accelerometer data of wearables

Inadequate physical activity increases the risk of various health problems. For wheelchair users, physical activity can be more challenging and daily goals are often not met. Wearables and e-platforms do not offer wheelchair users the same benefits as non-wheelchair users. With the help of accelerometer data obtained by multiple accelerometer devices, we studied human activity recognition (HAR) for strength exercises performed by 40 wheelchair users with a spinal cord injury (SCI) or lower limb amputation (LLA). The classification of seven strength exercise categories was done with supervised machine learning techniques including a recurrent neural network (RNN). To determine the performance of the classifier, we compared the performance between classifying strength exercises with daily activities. In addition, we tested our models to injury-specific subgroups to detect diversity between different types of wheelchair users. With these experiments, we concluded that creating a classification model for strength exercises in a free moving fitness environment is challenging. Wheelchair users tend to perform exercises with different execution forms, due to variation in physical limitations. Our model is not accurate enough for a reasonable adjustment to energy expenditure estimation with an accuracy score of 0.55. Improvement of the model within the field of strength exercises among wheelchair users is necessary before it can actually be deployed to wearables and e-platforms.
The effects of using biochar to remove ammonium nitrogen generated during the processing of biodegradable waste

The article described the attempt to use biochar as a sorbent to reduce the ammonia formed while composting a mixture of kitchen waste with chicken droppings and straw, and ammonium nitrogen from the leachate generated in this process. Two types of biochar were used, differing in the substrate used and the preparation temperature. The first biochar was prepared from beech wood chips (BBCh) at 600°C and the second from sewage sludge (BSS) at 500°C. The composting process was carried out for 10 d due to the largest ammonia emission that occurs at the initial stage of the composting process. It was found that the reduction of ammonia on the biochar prepared from sewage sludge was on average 17% lower compared to BBCh. The degree of ammonia reduction ranged from 54% (day 2) to 74.9% (day 10). The effluent formed during composting was treated under static conditions using both types of biochar. Their doses were changed in the range from 0.5 to 4.0 g dm−3. It was found that the sorption process with 10% higher efficiency, on average, took place on the biochar prepared from chips (BBCh). The rate of ammoniacal nitrogen removal for BBCh ranged from 17% (0.5 g dm−3) to 34% (4 g dm−3) and for BSS from 14% (0.5 g dm−3) to 24% (4 g dm−3). BBCh biochar is characterized by a greater sorption potential concerning both the removal of ammonia from gaseous products and ammonium nitrogen from leachate. Achieving better sorption effects is probably conditioned by a change in the surface chemistry of biochar in the modification process, and even their activation (especially in the case of BSS biochar).