Miracle-dz/UniFAR-FTUs huggingface dataset:
Excess Weight Gain With Integrase Inhibitors and Tenofovir Alafenamide: What Is the Mechanism and Does It Matter?

Abstract Numerous studies have detected a greater likelihood of excess weight gain with specific antiretrovirals (ARVs), particularly tenofovir alafenamide and integrase inhibitors, as compared with other agents and classes. The long-term implications and potential reversibility for individuals who have experienced substantial ARV-associated weight accumulation remain poorly understood. Furthermore, the underlying mechanism remains controversial: Is the explanation mitochondrial toxicity and weight suppression from the older agents or direct effects of the newer drugs on appetite, adipocytes, or other unintended targets? This review discusses proposed mechanisms and evidence to date and argues that the question about mechanism is highly clinically relevant because it carries significant implications for ARV management. The existing literature suggests that older ARVs, such as tenofovir disoproxil fumarate and efavirenz, suppress weight gain, but also that integrase inhibitors may stimulate excess weight gain through several plausible biologic pathways. Confirming the mechanisms of ARV-associated excess weight gain should be high priority for future research.
Construction of an Embankment with a Fly and Bottom Ash Mixture: Field Performance Study

Fly ash and bottom ash are coal combustion by-products (CCBPs) that are generated in large quantities throughout the world. It is often economical to dispose ash as mixtures rather than separately; that notwithstanding, only a few studies have been performed to investigate the behavior of fly and bottom ash mixtures, particularly those with high contents of fly ash. Also, there is very limited data available in the literature on the field performance of structures constructed using ash mixtures. This paper describes the construction and the instrumentation of a demonstration embankment built with an ash mixture (60:40 by weight of fly ash:bottom ash) on State Road 641, Terre Haute, Ind. Monitoring of the demonstration embankment was conducted for a period of 1 year from the start of construction of the embankment. The settlement of the embankment stabilized approximately 5 months after the end of its construction. According to horizontal inclinometer readings, the differential settlement at the top of the embankment is about 5 mm. Results from field quality control tests performed during construction of the demonstration embankment and monitoring data from vertical and horizontal inclinometers and settlement plates indicate that the ash mixture investigated can be considered an acceptable embankment construction material.
A soil-tool model based on limit equilibrium analysis

ABSTRACT A mathematical model for predicting the behavior of narrow tillage tools in soils is based on a limit equilibrium analysis. Pertinent soil, tool and interface parameters influencing the tool performance have been identified and incorporated in the model. A comparison of predicted and experimental results is also included. Mathematical models based on emperical as well as semi-emperical methods have been developed to describe the soil-tillage tool interaction (Payne, 1956; Hettiaratchi and Reece, 1967; Hettiaratchi et al., 1966; Osman, 1964; Godwin and Spoor, 1977; McKyes, 1978; Desai et al., 1981). Even though the soil-tool interaction problem is three dimensional in nature, a majority of the models available are based on two-dimensional consideration (Hettiaratchi et al., 1966; Osman, 1964; Payne, 1956). In recent years some progress has been made toward the development of three dimensional models (Hettiaratchi and Reece, 1967; Godwin and Spoor, 1977; McKyes, 1978). However, most of these models are complex, and a sound mathematical background is essential to utilize them. Thus the need exists for more general and less complex models capable of predicting tillage-tool behavior in soils. Unlike costly experimental procedures, availability of such models would permit designers as well as researchers to develop with minimum effort a clear understanding of soil-tool interaction through parametric studies. Therefore, the overall objective of this study was to develop a generalized mathematical model and to examine its validity for predicting the tillage tool performance in soils.
Effects of project-based learning in education-enterprise collaboration to learning experience and student engagement

Studies of management can be built around multiple pedagogical principles, from lecture- and reading-based methods to case studies, project- and problem-based studies or even holistic development programmes performed in collaboration with corporate partners. In wider entities mixing some of the above methods is typical. This paper looks at the impact on learning experience of engaging live projects – performing research and development assignments for existing technology companies – as part of the one-semester specialization programme of hightech management at JAMK University of Applied Sciences in Finland. In evaluation of the rationale of this pedagogical choice this paper utilizes the learnings of prior-art research as well as the guidance given by the legislation and the strategy of the institution. The results indicate that this pedagogical approach has the potential to deliver better learning outcomes compared to other traditional types of courses at JAMK offered by the same teachers.
A New Implementation of PMU Based on Streamed Values of IEC 61850 Process-Bus

This paper assessing the performance of a simulated PMU fed by streamed measured values as defined in IEC 61850. The PMU is designed and implemented based on the so-called Unscented Kalman Filter algorithm and proposed as a centralized computation tool. The communications among PMUs and central control room is accomplished based on Ethernet network communications. Although that Ethernet-based communications can be appropriate and reliable for many power applications, it is recommended to assess the impacts of its communication network errors such as network bandwidth and clock errors and how their influence on the estimated phasor. This proposed implementation can help power utilities to track any dynamic change and improve the state estimation of the system. MATLAB®/Simulink® is used in conjunction with true-time software that is developed by ABB to mimic the process-bus communication of IEC 61850 in this work. Representative results in assessing the impacts of the errors on PMU’s performance are presented in the paper.
Use of biochar for alleviating negative impact of salinity stress in corn grown in arid soil

Abstract: Tremendous benefits of biochar (BC) amendment to soil have been reported, including their role in alleviating the impact of salinity stress in plants. The aim of this study was to evaluate the effects of BC produced at 300 °C (BC300) and 700 °C (BC700) on the germination rate (GR) and selected growth characteristics of corn plants irrigated with salinized water over a growth period of 6 weeks. The experimental treatments included three biochar treatments: BC0 (control, without biochar addition), BC300, and BC700. The treatments also included three salinity levels of irrigation water: 0, 3, and 6 dS·m−1. The biochar was applied at a rate of 3%. The GR decreased with increasing salinity level, which was more evident in the first week. This stress impact was reduced when treated with the BC700 relative to the saline treatments without BC. Both BC treatments demonstrated contrasting effects on corn growth, nutrient uptake, and Na+ and K+ content in plant tissue. The effect of BC700 treatment on plant height and root length was limited, but the impact of salinity stress on chlorophyll meter readings, chlorophyll fluorescence parameter (Fv/Fm), dry matter yield, and N and P uptake were largely mitigated. It also increased K+ and decreased Na+ content in plant tissue. However, the BC300 treatment adversely affected plant growth parameters at each salinity level. Overall, the BC produced at a higher temperature significantly alleviated the impact of salinity stress on plant growth characteristics, which is probably attributed to their higher surface area and porosity, enhancing their salt ion sorption capacity.
CTIM-25. A RANDOMIZED PHASE 3 STUDY OF NIVOLUMAB OR PLACEBO COMBINED WITH RADIOTHERAPY PLUS TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA WITH METHYLATED MGMT PROMOTER: CHECKMATE 548

Novel therapies are needed in newly diagnosed glioblastoma as nearly all patients experience recurrence following standard-of-care radiotherapy (RT) + temozolomide (TMZ), including patients with tumors with methylated MGMT promoter, a positive prognostic factor and predictor of benefit with TMZ. Here, we report the final analysis of progression-free survival (PFS), overall survival (OS), and safety from an international randomized, single-blind phase-3 study of nivolumab (NIVO)+RT+TMZ in patients with newly diagnosed glioblastoma with methylated/indeterminate MGMT promoter (CheckMate 548; NCT02667587). Patients (N=716) aged ≥ 18y were randomized 1:1 regardless of tumor PD-L1 expression to NIVO (240 mg Q2W×8, then 480 mg Q4W) + RT (60 Gy over 6 weeks) + TMZ (75 mg/m2 QD during RT, then 4-week break, then 150–200 mg/m2 QD on days 1–5 of every 28-day cycle for 6 cycles) or placebo (PBO)+RT+TMZ. The dual-primary endpoints were PFS by blinded independent central review and OS, both overall and without baseline corticosteroids. As of December 22, 2020, median PFS was 10.6 months (95% CI, 8.9–11.8) with NIVO+RT+TMZ and 10.3 months (95% CI, 9.7–12.5) with PBO+RT+TMZ (HR, 1.06 [95% CI, 0.90–1.25]). Median OS was 28.9 months (95% CI, 24.4–31.6) with NIVO+RT+TMZ and 32.1 months (95% CI, 29.4–33.8) with PBO+RT+TMZ (HR, 1.10 [95% CI, 0.91–1.33]). Among patients without baseline corticosteroids, median OS was 31.3 months (95% CI, 28.6–34.8) with NIVO+RT+TMZ and 33.0 months (95% CI, 31.0–35.1) with PBO+RT+TMZ (HR, 1.12 [95% CI, 0.87–1.43]). Grade 3–4 treatment-related adverse events were 52.4% and 33.6% with NIVO+RT+TMZ and PBO+RT+TMZ, respectively. NIVO added to RT+TMZ did not improve survival in patients with newly diagnosed glioblastoma with methylated/indeterminate MGMT promoter. No new safety signals were observed with NIVO. The role of immunotherapy in this treatment landscape remains an area for further investigation.
Realizing the Need for Digital Transformation of Stakeholder Management: A Systematic Review in the Construction Industry

The construction industry is among the least digitized industries, and the lack of innovation in construction project management practices has led to decreases in productivity. The European Directives for Public Procurement are pushing the entire construction supply chain towards more radical digital transformations over the next years, and project managers are left with the difficult task to harness ICT for the involvement and management of project stakeholders. Digitalization of various processes and practices used to manage stakeholders in construction projects is still low, and part of this problem lies in weak systematization of ICT systems which support these practices. Thus, this paper provides a systematic review of how digitalization and digital transformation affect the way stakeholders behave, engage, and communicate in projects. Following the PRISMA methodology, 73 sources from the literature were chosen for the final analysis. Results are presented through descriptive and qualitative content analysis. Six research topics were identified and thoroughly analyzed. Results show that BIM, social network analysis, and web-based applications as means to digitalize stakeholder management are more mature than social media and VR/AR. An important finding is the need to reengineer and digitally transform processes in construction projects and construction firms to enable further digitalization and effectiveness of digital technologies. Suggestions for further studies follow this line of thought.
Possibilities for Coping Strategies Development of Management Students

Coping with demanding situations is a regular part of managerial work; therefore, training in it ought also to be part of the pre-graduation preparation of students of Management. From a managerial perspective, demanding situations are perceived as either unpleasant or as a potential opportunity for career advancement. This paper presents the results of an experimental research project investigating coping strategies development, specifically among students of Management. An experimental group underwent specific preparation, whereas a control group did not. The experiment was conducted on a research sample of 293 management students using the COPE (b) methodology. The experimental results confirmed statistically significant differences between the ante- and the post-measurement within the experimental group in terms of these five coping strategies: Positive reframing, Active coping, Planning, Humour, and Venting. Within the control group, no significant differences were recorded.
Association of insulin-like growth factor 1 (IGF1) gene polymorphism with the reproductive performance of three dual-purpose chicken breeds

Abstract The study was designed to investigate the association of Insulin-like growth factor 1 (IGF1) gene polymorphism with the reproductive performance of FUNAAB-Alpha, Sasso, and Kuroiler dual-purpose chicken breeds. To achieve this, a total of 250 healthy hens were selected at 12 wk of age and were intensively managed in cages for 52 wk. Blood sample was taken from each chicken at the 34th week and genomic DNA was extracted using Qiagentm DNA extraction kit, PCR was used to amplify the DNA fragments, and the PCR products were electrophoresed. Amplicons obtained were digested with restriction enzyme hinf1, and were further electrophoresed on 1.5% agarose gel. Data obtained were analyzed using the General linear model of SAS (2002) version 9.0 to determine the effect of IGF1 gene polymorphism and the distribution of alleles within the breeds. Results show polymorphism of the IGF1 gene and the restriction analysis indicated two alleles; A 58% and C 42% with the identification of genotypes AA, AC, and CC, and genotypic frequency of 22%, 43%, and 35%, respectively. Significant associations were observed between the polymorphism of the IGF1 gene, age of the bird at first lay, and weight of the hen at first lay. Chickens with haplotype CC came earlier into lay compared to those with the other two haplotypes (AA and AC). Therefore, the study suggests that haplotype CC could be used as a genetic marker to select for an improved laying performance in chickens.
The Effects of Different Exercise Modalities in the Treatment of Cardiometabolic Risk Factors in Obese Adolescents with Sedentary Behavior—A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Purpose: Obesity has become increasingly prevalent in adolescents due to unhealthy diet habits, sedentary behavior and a lack of physical activities. This study aims to assess the effects of different exercise modalities in the treatment of cardiometabolic risk factors (CRF) in obese adolescents with sedentary behavior. Methods: A systematic search was conducted using databases (PubMed, Embase, Cochrane library, Web of Science, CNKI and VIP database) from the earliest available date to August 2021. Nineteen randomized controlled trials (RCTs) with 704 participants were included. The included studies were evaluated for methodological quality by the Cochrane bias risk assessment tool, and a statistical analysis was performed by the Review Manage 5.3 and Stata 15.1 software. Results: The results of the meta-analysis showed that exercise could significantly improve obese adolescents’ body mass index (BMI) (MD = −1.99, 95% CI: −2.81 to −1.17, p < 0.00001), low density liptein cholesterol (LDL-C) (SMD = −0.98, 95% CI: −1.58 to −0.37, p = 0.002), triglyceride (TG) (SMD = −0.93, 95% CI: −1.72 to −0.14, p = 0.02), total cholesterol (TC) (SMD = −1.00, 95% CI: −1.73 to −0.26, p = 0.008), peak oxygen uptake (VO2peak) (MD = 3.27, 95% CI: 1.52 to 5.02, p = 0.0003) and homeostatic model assessment insulin resistance (HOMA-IR) (SMD = −2.07, 95% CI: −3.3 to −0.84, p = 0.001). However, there was no statistically significant difference in high-density liptein cholesterol (HDL-C) (SMD = 0.40, 95% CI: −0.28 to 1.08, p = 0.25). Conclusion: Exercise can effectively improve cardiometabolic risk factors in obese adolescents with sedentary behavior. For obese adolescents who want to lose weight and improve cardiorespiratory fitness, combined aerobic and resistance training and high-intensity interval training are optimal choices. For obese adolescents with high blood lipids, aerobic training can be regarded as a primary exercise modality to reduce the high risk of cardiovascular diseases; For obese adolescents with insulin resistance, combined aerobic and resistance training can be considered to reduce the high risk of diabetes. It is hoped that more high-quality studies will further expand the meta-analysis results and demonstrate the optimal exercise frequency and treatment intensity of cardiometabolic risk factors in obese adolescents with sedentary behavior in the future.
Identification of Preferred Chemotherapeutics for Combining with a CHK1 Inhibitor

Here we report that GNE-783, a novel checkpoint kinase-1 (CHK1) inhibitor, enhances the activity of gemcitabine by disabling the S- and G2 cell-cycle checkpoints following DNA damage. Using a focused library of 51 DNA-damaging agents, we undertook a systematic screen using three different cell lines to determine which chemotherapeutics have their activity enhanced when combined with GNE-783. We found that GNE-783 was most effective at enhancing activity of antimetabolite-based DNA-damaging agents; however, there was a surprisingly wide range of activity within each class of agents. We, next, selected six different therapeutic agents and screened these in combination with GNE-783 across a panel of cell lines. This revealed a preference for enhanced chemopotentiation of select agents within tumor types, as, for instance, GNE-783 preferentially enhanced the activity of temozolomide only in melanoma cell lines. Additionally, although p53 mutant status was important for the overall response to combinations with some agents; our data indicate that this alone was insufficient to predict synergy. We finally compared the ability of a structurally related CHK1 inhibitor, GNE-900, to enhance the in vivo activity of gemcitabine, CPT-11, and temozolomide in xenograft models. GNE-900 significantly enhanced activity of only gemcitabine in vivo, suggesting that strong chemopotentiation in vitro can translate into chemopotentiation in vivo. In conclusion, our results show that selection of an appropriate agent to combine with a CHK1 inhibitor needs to be carefully evaluated in the context of the genetic background and tumor type in which it will be used. Mol Cancer Ther; 12(11); 2285–95. ©2013 AACR.
Binocular therapy as primary intervention in adults with anisometropic amblyopia

PURPOSE: Refractive correction and patching is the timetested mainstay of treatment for anisometropic amblyopia within the critical period of visual development. Binocular therapies using dichoptic training which overcome suppression by balancing the contrast between two eyes has been increasingly gaining ground. We evaluated the efficacy of dichoptic training in the adult population with anisometropic amblyopia. This study aims to evaluate the effectiveness of dichopticbased active vision therapy, using “VisuoPrime” software as primary intervention, in adults with anisometropic amblyopes. MATERIALS AND METHODS: A prospective interventional study in adults (18–40 years) with anisometropic amblyopia was conducted from August 2019 to March 2020. METHODS: Twentynine subjects with anisometropic amblyopia played binocular games through “VisuoPrime” software 30 min daily for 6 weeks. Bestcorrected visual acuity (BCVA) and binocularity was assessed at 1 and 3 months. Student's paired ttest, Wilcoxon signedrank sum test and MannWhitney tests were used. Statistical package of SPSS version 20.0 was used for analysis, considering P < 0.05 as statistically significant. RESULTS: BCVA of the amblyopic eye improved from 0.60 ± 0.40 logMAR to 0.45 ± 0.29 logMAR and 0.38 ± 0.23 logMAR at 1 and 3 months, respectively (P = 0.0001). Near acuity improved from 0.21 ± 0.14 to 0.14 ± 0.08 logMAR and 0.1 ± 0.04 logMAR at 1 and 3 months respectively (P < 0.0001). Improvement in stereopsis was observed in 24% of subjects which maintained at 3 month followup. CONCLUSION: Dichopticbased active vision therapy using “VisuoPrime” software was effective as a primary modality in adults with anisometropic amblyopia.
Interdisciplinary Approach to Environmental Education

This paper examines the need for an interdisciplinary educational approach in environmental engineering and science, discusses the constituents of interdisciplinary environmental education, and addresses its advantages. A case of interdisciplinary environmental education within the Interfaculty Graduate Environmental Sciences Program at the American University of Beiurt is then presented. Specifically, this newly created program is introduced with a description of its structure, content, and performance in terms of mission accomplishment, student enrollment, and marketability of its graduates. Future curriculum development and constraints are also examined.
The transcription factor AtHB23 modulates starch turnover for root development and plant survival under salinity

AtHB23 is a homeodomain-leucine zipper I transcription factor, previously characterized as a modulator of lateral root initiation and higher-order roots development. The role of this gene in response to salinity stress was completely unknown. To elucidate the role of AtHB23 in response to salinity stress, we combined histochemical β-glucuronidase (GUS) analysis, root phenotyping, starch staining, optic and electronic transmission microscopy, expression studies by RT-qPCR, and transcriptome analysis of silenced, overexpressor, and crossed plants. We revealed that the expression pattern of AtHB23 is regulated by NaCl in the main and lateral roots, affecting the root phenotype. A severe reduction in primary root length, a significant increment in the initiation of lateral roots, and a low survival rate in salinity conditions were observed in AtHB23-silenced plants, whereas AtHB23 overexpressors showed the opposite phenotype. These developmental defects were explained by the degradation of starch granules and an alteration in starch metabolism. The AtHB23-target gene LAX3 is repressed in the tip of the main root and affected by NaCl. We conclude that AtHB23 is vital for plant survival and adaptation to salt stress conditions, and its function is related to the gravitropic response mediated by starch granule turnover, involving the auxin carrier LAX3. Highlight The transcription factor AtHB23 is crucial for plant survival and adaptation to salt stress conditions, and its function is related to the gravitropic response mediated by starch-granule turnover, involving LAX3.
Complete Genome Sequences of Klebsiella michiganensis and Citrobacter farmeri, KPC-2-Producers Serially Isolated from a Single Patient

Carbapenemase-producing Enterobacterales, including KPC-2 producers, have become a major clinical problem. During an outbreak in Quebec City, Canada, KPC-2-producing Klebsiella michiganensis and Citrobacter farmeri were isolated from a patient six weeks apart. We determined their complete genome sequences. Both isolates carried nearly identical IncN2 plasmids with blaKPC-2 on a Tn4401b element. Both strains also carried IncP1 plasmids, but that of C. farmeri did not carry a Beta-lactamase gene, whereas that of K. michiganensis carried a second copy of blaKPC-2 on Tn4401b. These results suggest recent plasmid transfer between the two species and a recent transposition event.