Miracle-dz/UniFAR-FTUs huggingface dataset:
Full scale rapid uplift tests on transmission tower footings

This paper describes results from a series of full scale tests on transmission tower footing at a London clay site in Kent. The testing series investigated the effects of rapid loading at field scale with footings founded directly onto clay or coarse granular material, with a clay or coarse granular material backfill. It was shown that footings founded on London clay mobilised significantly greater uplift capacities at smaller displacements than those with a breakaway condition. In a suite of centrifuge tests this enhanced capacity was shown to originate from suctions that formed on the base of model footings (Lehane et al. 2008). Back analysis of the field tests revealed that inferred normalised suctions were similar to those generated in the centrifuge tests. However the enhanced uplift capacity was not sufficient to cause the uplift resistance to reach design capacity by the displacement serviceability limit state of 10mm. RÉSUMÉ : Cet article présente les résultats issus d’une série de tests grandeur nature sur les fondations d’une tour relais basées sur un terrain en argile de Londres (London clay), dans le Kent, Angleterre. Ces séries de tests ont été menées pour étudier les effets d’un chargement rapide en conditions réelles avec une tour remblayée et fondée dans un sol argileux ou un matériau granuleux. Il a déjà été prouvé que, pour de petits déplacements, des fondations basées sur de l’argile de Londres présentaient une résistance à l’arrachement plus importante que des fondations placées sur une base en gravier. Des essais en centrifugeuse ont montré que cette résistance à l’arrachement accrue provenait de succions sur la base de la maquette (Lehane et al. 2008). De nouvelles analyses sur le terrain ont révélé que les forces de succion calculées étaient similaires à celles générées durant les tests de centrifugeuses. Cependant cette meilleure résistance à l’arrachement n’a pas été suffisante pour satisfaire la limite de résistance imposée par le cahier des charges pour un déplacement fonctionnel de 10mm.
Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide GnRH Antagonist Elagolix

ABSTRACT Context: Parenteral administration of peptide GnRH analogs is widely employed for treatment of endometriosis, fibroids and in assisted-reproductive therapy protocols. Elagolix is a novel, orally available nonpeptide GnRH antagonist. Objective: To evaluate the safety, pharmacokinetics and inhibitory effects on gonadotropins and estradiol of single dose and 7-day elagolix administration to healthy premenopausal women. Design: This was a first-in-human, double-blind, placebo-controlled, single- and multiple dose study with sequential dose-escalation. Participants: Fifty-five healthy, regularly cycling pre-menopausal women. Interventions: Subjects were administered a single oral dose of 25 to 400 mg or placebo. In a second arm of the study, subjects received placebo or 50, 100, or 200 mg q.d. or 100 mg b.i. d. for seven days. Treatment was initiated on Day 7 (±1) following onset of menses. Main Outcome Measures: Safety, tolerability, pharmacokinetics and serum LH, FSH and estradiol concentrations.
Purchasing digitalisation as a leading means for achieving effectiveness

Being a prerequisite for the further development of the procurement system, digitalization completely changes the purchasing function and affects its effectiveness through various factors, the main of which are quality and savings, risk minimization, and speed increase. In short, all of the above allows to achieve leading position and prominent standing. Moreover, through using digital technologies it is possible to identify those places in the supply chain where failures are associated with the factors highlighted in this study, eliminate them, and in the future predict in advance and minimize the occurrence of a repeated situation. In addition, the use of technology leads to the necessity of a new efficiency system with new key performance indicators. In the future, collecting information on key indicators allows to build an econometric model for evaluating the effectiveness of the procurement system as a whole, taking into account the use of digital technologies, which will be relevant for state and municipal procurement bodies.
Employee Satisfaction and Firm Performance

Using a unique data set drawn from self administered employee surveys for 1495 US public corporations; I construct an Employee Satisfaction Index (ESI) and use it as a proxy for employee satisfaction. I find that ESI is higher for larger firms, high market to book ratio firms and firms that have low leverage. I also look at the effect of the changes in ESI on quarterly earnings announcements. I find that the changes in ESI are positively and significantly related to the future quarterly earnings surprises. Moreover, the effect is stronger for companies that have higher information asymmetries and are more human capital dependent. My results are robust to past returns, analyst information, alternative specifications of CAR windows and the information environment surrounding the earnings announcements. The results are consistent with the theories that state that employees are insiders in a company and have information relevant to the future corporate performance. Moreover, consistent with human-capital centric theories I find evidence that the change in employee satisfaction has a greater effect on the performance of human-capital dependent companies. ___________________________ *I would like to express my immense gratitude to Tony Bernardo and Avanidhar Subrahmanyam, for their valuable critiques, suggestions and support. I would also like to thank, Jennie Brand, Mark Garmaise and Geoff Tate for helpful comments. I am grateful to the private survey company for providing me with the employee survey data. All errors are my responsibility. 1 Assistant Professor of Finance at University of New Mexico, Anderson School of Management, 1 University Blvd NE, Albuquerque, NM 87131, ph: 310-733-0271, Email: sahluwalia@unm.edu.
From playing games to committing crimes: A multi-technique approach to predicting key actors on an online gaming forum

We propose a systematic framework for analysing forum datasets, which contain minimal structure, and are nontrivial to analyse at scale, aiming to support future analysis of underground forum communities. We use a multi-technique approach which draws on a combination of features, including post classifications extracted using natural language processing tools, and apply clustering and predictive techniques to this dataset, to predict potential key actors—individuals who have a central role in overtly criminal activities, or activities which could lead to later offending, and hence might benefit most from interventions. We predict 49 key actors on an underground gaming-specific cheating and hacking forum, validated by observing only overlaps of techniques, combined with topic analysis, to build a classifier for key actor status. In addition, we also use these techniques to provide further insight of key actor activity. We found one cluster and two posting trajectories to contain a high proportion of key actors, logistic regression found an actor's h-index to have higher odds for prediction than other features, and partial dependence plots found reputation to have a significant change in prediction between values of 100 to 1000.
BULLETIN OF THE MİNERAL RESEARCH AND EXPLORATION

s of the papers published only in the Turkish edition of this bulletin Notes to the authors GENERAL DIRECTOR Ali Kemal IŞIKER EDITORIAL BOARD Ergün AKAY Berk BESBELLİ Erhan ÖNDER U. Kağan TEKİN Tandoğan ENGİN İsmail İNEL Ahmet TÜRKECAN
THREE-DIMENSIONAL GAIT ANALYSIS AFTER UNILATERAL CEMENTED TOTAL HIP ARTHROPLASTY

The gait of 20 patients with unilateral hip disease, who underwent total hip arthroplasty (THA), was analyzed preoperatively and 12 months after a unilateral THA, using a zebris ultrasound-based three-dimensional motion analysis system. The constant gait speed was 2.5 km/h. The spatial-temporal and angular parameters were compared to the gait parameters of 20 healthy, elderly subjects. The aim of this study is to determine how selected gait parameters may change as a result of total hip arthoplasty at a constant gait speed. Before the THA, asymmetry was observed in spatial-temporal parameters, in the range of hip motion, maximum hip flexion, maximum hip extension, as well as in knee motion. Therefore, it was suggested that the increased motion of the opposite hip and knee was a compensatory function. The study showed that increased pelvic obliquity and flexion-extension occurred as compensation. It seems that the range of pelvic rotation was not involved, even in our patients with unilateral osteoarthritis of the hip joint. At 12 months after the THA, no asymmetry of spatial-temporal parameters and of the knee and hip joint motion could be observed, and the increased pelvic motion also became less significant. Therefore, this study suggested that the THA could reverse the adverse influence on other joints prior to the symmetrical normalization of hip motion.
Anticancer Effect of the Ethyl Acetate Fraction from Orostachys japonicus on MDA-MB-231 Human Breast Cancer Cells through Extensive Induction of Apoptosis, Cell Cycle Arrest, and Antimetastasis

The antibreast cancer activities of the ethyl acetate fraction from Orostachys japonicus (OJEF) were investigated in MDA-MB-231 human breast cancer cells through WST assay, DAPI staining, flow cytometry analysis, and western blotting. OJEF effectively inhibited MDA-MB-231 cells by inducing apoptosis via intrinsic, extrinsic, and endoplasmic reticulum (ER) stress response pathways, cell cycle arrest at the G1/S phase, and antimetastasis including inhibition of tight junction, adherens junction, invasion, and migration. The MAPK family-mediated upstream signal transduction through p-p38 and p-ERK was considered to affect the downstream signal transduction including induction of apoptosis, cell cycle arrest, and antimetastasis. In conclusion, we executed an integrated study on the anticancer activities of OJEF, which extensively induced apoptosis, cell cycle arrest, and antimetastasis in estrogen-independent MDA-MB-231 human breast cancer cells known to be liable to metastasize.
Investor anticipation of dividend initiations and omissions-Do investors really underreact?

In this paper, we assess investors’ anticipation of dividend initiations and omissions, and the extent to which investor anticipation about the likelihood of these events can influence their valuation effects. We find a negative and statistically significant relationship between the degree of investor anticipation and the magnitude of the announcementperiod abnormal returns for dividend initiating and omitting firms. Using Propensityscore matching to obtain counterfactual firms that are equally likely from the investors’ perspective to initiate or omit dividend payouts, we estimate the valuation effects of dividend initiations and omissions. We find no reliable evidence of long-run abnormal returns in the three years following dividend initiations and omissions, but robust evidence of pre-announcement abnormal returns. These abnormal returns are, in the case of omissions, negatively related to announcement-period and post-announcement abnormal returns, suggesting that event-related information is incorporated into prices prior to the announcement. Keywords— Dividend initiations, dividend omissions, information content, underreaction, investor anticipation, self-selection john.cotter@ucd.ie; j.h. von.eije@rug.nl; mohamad.faour@ucdconnect.ie; cal.muckley@ucd.ie The authors would like to thank Shivam Agrawal, Claudia Custodio, Emmanuel Eyiah-Donkor, Halit Gonenc, Bruce Grundy, Jens Hagendorff, Niels Hermes, Ranko Jelic, Chenglu Jin, Henning Schroeder, Grzegorz Trojanowski, Patrick Verwijmeren, seminar participants at the University of Groningen, the Centre for Financial Markets at University College Dublin, the 2015 Australasian Finance and Banking Conference, the 2018 Corporate Finance Workshop at Queen’s University Belfast, the 2018 Young Finance Scholars Conference at
Associations between Leisure Activities and HIV Risk Behaviors among Rural Migrants in Urban China

Although much has been documented on factors affecting HIV risk behavior among rural-to-urban migrants in China, data are lacking on the impact of leisure activities. In this study, we examined the association between leisure activities and HIV risk behavior among a sample of rural-to-urban migrants from two large cities (Beijing and Nanjing) in China. Cross-sectional data were analyzed for a sample of 4,085 participants aged 18 to 30 years (40.5% females). Findings from the analysis indicated that although the migrants worked long hours, they engaged in a number of activities when they did not work, including watching television (60.2%), reading (59.1%), sleeping (55.6%), and chatting with friends and co-workers (45.0%). Multiple regression analysis indicated that reading, doing chores (females only), listening to radio programs/audio CDs (male only) were associated with reduced likelihood of HIV risk behavior while playing cards in groups, visiting entertaining installments, watching videos (including Xrated, males only), and wondering around (females only) were associated with increased likelihood of HIV risk behavior. Findings of this study suggest that constructive and individualized activities (e.g., reading, listening to radios, and doing chores) may prevent migrants from engage in HIV risk behaviors while group and entertaining activities related to drugs and sex may increase the odds for migrants to engage in HIV risk behaviors. Prevention research should consider leisure activities as both an influential factor (including time trends and gender differences) for program development and an important venue for program delivery.
Response of Barki ewes to treatment with gonadotrophin hormones and energy supplementation (flushing).

Thirty six of Barki ewes (2.5 4 years of age) with a live body weight of 40-50 kg were used to determine the influence of PG-600 (a combination of pregnant mare’s serum gonadotrophins and human chorionic gonadotropin) and (or) energy supplementation (flushing) on estrous activity, ovarian activity, reproductive performance and progesterone concentration. Ewes were randomly assigned to four groups (9 in each): T1 untreated control: Ration supplying 100% of ewes energy requirements (60 %) from concentrate feed mixture (CFM) + (40%) from berssem hay, T2: Flushing (for 9 days before ram introduction for mating), cover 110% of ewe's energy requirements (60 %) from yellow corn meal + (40%) from berssem hay, T3: single 5-ml intramuscular injection of PG-600 (It contains 400 IU of pregnant mare serum gonadotropin and 200 IU of human chorionic gonadotropin) were applied on the evening of the ninth day before introduction of ram to ewes and T4: as T2 + single 5-ml intramuscular injection of PG-600 immediately after the last feeding of T2. The ninth day all ewes were exposed till 35 days to fertile ram. Ewes were observed three times daily for signs of behavioural estrus. The nutritional requirements for the ewes were calculated according to the NRC (1989).
Immunosuppression and histopathological changes in the bursa of Fabricius in chickens with different vaccine schedules against infectious bursal disease (IBD)

The level of antibody by ELISA,immunsosuppressive effect baes on the response of birds to Newcastle disease vaccination and damage to bursa of Fabricius by IBD vaccination were studied. The efficacy of six different IBD vaccination schedules were studied using intermediate and intermediate plus strains of vaccines either alone or in combination. In vaccinated groups, the sero-conversion of the vaccine virus was noticed during fourth week, reaching to the peak between eight to twelve weeks of age in different groups. Afterwards, there was a gradual decrease in the titres, by the end of 20th week (maximum period tested). There was no significant difference in the titres of different treatment groups. However, all the groups showed titres above protective level during the entire period of study. There was significant difference in bursa body weight (B-BW) ratios of vaccinated groups in comparison with control group. Histopathological studies of bursal sections revealed depletion of lymphoid follicles, presence of cystic spaces, edema and hemorrhages. The birds vaccinated with hot strain of IBD vaccine showed metaplastic changes, presence of foam cells with pronounced interfollicular fibrosis. The bursal scores were maximum in the groups vaccinated with hot strains of IBD vaccines.
Vitamin D and Ischemic Stroke

Introduction: stroke is the most important brain disease. Stroke leads to a reduction in bone density, altered calcium homeostasis, and an increase in hip fractures. Some recent studies show effects of vitamin D on stroke and vice versa. The purpose of this study was to determine of serum vitamin D levels in patients with acute stroke. Methods: In this cross-sectional study, we compared the serum 25-dihydroxyvitamin D levels of 44 patients with first-ever ischemic stroke with results obtained by measuring 44 healthy ambulant elderly subjects. Data were analyzed using T-test and ANOVA. Results: patients in two groups were male and the rest were female. The average age of all patients in both groups were ±13.4. The mean of serum vitamin D in acute stroke was . 1±6.33 and in control group was 4±5.28. There was no significant difference between the two groups on serum level of vitamin D. There was no significant difference between serum vitamin D with age and sex. Conclusion: There was no difference in serum vitamin D in patients with acute stroke and controls.
SUNCA standardized extract from Helianthus annus L exerts enhanced digestive enzyme activity and subsides obesity through inhibition of C/EBP-α and PPAR-γ expression both in in vitro and in vivo model

Background: Helianthus annuus L. (sunflower) is well known for its edible oil, sunflower seed has been used as folk remedy for several diseases including cancer. Materials and Methods: In this study, SUNCA, a standardized extract enriched with chlorogenic acid (CGA) from sunflower seed was investigated for in vitro antidiabetic activity using α-amylase and α-glucosidase enzyme inhibition assay. Further, for preventing obesity, we demonstrated anti-adipogenesis in 3T3-L1 cell culture system and on body weight gain and adiposity in rat fed high-fat diet (HFD). Results:SUNCA showed significant inhibitory activity toward digestive enzymes such as α-amylase and α-glucosidase. On the other hand, SUNCA significantly inhibits lipid accumulation during adipogenesis in a dose-dependent manner. The treatment with 100 μg/kg b.w of SUNCA apparently prevented the body weight gain and the increase of triglyceride and total cholesterol level in rat fed an HFD for 6 weeks. Further immunoblotting studies reveal that SUNCA significantly down-regulates the expression of transcription factors peroxisome proliferator-activated receptor gamma and CCAT/enhancer-binding protein alpha, both in adipocytes and adipose tissues. Conclusion: The findings reported here provide the therapeutic potential of SUNCA, a standardized extract from Helanthus annus L.
Comparative in vitro and in silico characterization of anticancer compounds piceatannol, biochanin-A and resveratrol on breast cancer cells

Background: Biochanin-A and Piceatannol are phytochemical constituents extracted from Sophora interrupta. Although both the compounds were isolated from a single plant, these compounds were not compared against anticancer activity. Objective: A systematic comparative analysis of biochanin-A, piceatannol, and resveratrol was performed to investigate cancer cell viability, motility, metabolic changes in Michigan Cancer Foundation-7 breast cancer cells, and structure compound interaction with the vascular endothelial growth factor (VEGF) receptors were studied. Materials and Methods: Cancer cell viability was studied using 3 (4, 5 dimethyl thiazol 2yl) 2, 5 diphenyltetrazo- lium bromide and acridine orange (AO)/ethidium bromide (EtBr) assay. The wound-healing assay was performed by measuring cell migration from the scratch area. Metabolic changes of the compounds in culture conditions were recorded using Fourier-transform infrared (FT-IR) spectroscopy. Molecular docking and dynamic simulations were performed using Schrödinger software. Results: Our results showed that the half-maximal growth inhibitory concentration for biochanin-A is 150 μM/ml and piceatannol and resveratrol showed 150 μM/ml, which is evident from the uptake of AO and EtBr dyes by live/dead cells. Moreover, drug-treated cells were unable to fill the cleared area from the scratch area, which suggests that all compounds effectively inhibit cell motility. FT-IR fingerprint showed a marked difference in the percentage of transition and dynamic structural changes between untreated and treated samples. Strong hydrogen-bond interaction with VEGF receptor-1 (VEGFR1) and VEGFR2 proteins and their interactions were stable throughout the simulation period. Moreover, these compounds inhibited sprouting of a new blood vessel from the chicken aorta and microvessels formation in the in ovo chorioallantoic membrane assay. Conclusion: Taken together, we conclude that anticancer and anti-angiogenic activity, structure-function relationship of biochanin-A is like well-known anticancer compound resveratrol and its metabolic product piceatannol in breast cancer cells.
Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction

Aim: The aim was to study the correlation of hepatic artery resistive index (HARI) with the portal pressure (PP) and its surrogate marker serum nitric oxide (NO) levels and to determine the validity of HARI as noninvasive indirect marker of PP in extrahepatic portal venous obstruction (EHPVO) pre- and postoperatively. Methods: A prospective study was conducted on 19 patients with EHPVO undergoing proximal lienorenal (LR) shunt or devascularization from February 2016 to January 2018. HARI, calculated from Doppler sonography, and NO were measured preoperatively and 14, 30 and 90 days postoperatively. Intraoperatively, PP was measured before splenectomy, and both PP and NO were measured postshunt. Results: Mean age was 10.58 ± 2.85 years, and male:female ratio was 15:4. LR shunt was done in 16 while three patients required devascularization. There was a significant fall in the HARI (0.06 ± 0.02, P = 0.02), NO (14.31 ± 2.66 μmol/l, P < 0.001), and PP (11.81 ± 1.03 mmHg, P < 0.001) following shunt surgery. However, fall in HARI did not correlate with fall in PP. Preoperative HARI also did not correlate with preshunt/devascularization PP nor with preoperative NO. Postoperatively, HARI did not correlate with NO at 14-, 30-, and 90-day follow-up. Conclusion: HARI bears no correlation with PP or NO. Hence, it cannot be used as an indirect marker of PP.