Miracle-dz/UniFAR-FTUs huggingface dataset:
A 12-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Topiramate for the Treatment of Compulsive Buying Disorder.

BACKGROUND Topiramate is an anticonvulsant that has shown promise as a pharmacological agent for the treatment of addictive disorders, including compulsive buying disorder (CBD). The aim of the present study was to examine the efficacy of topiramate in the treatment of CBD and its associated characteristics using a 12-week randomized, double-blind, placebo-controlled design. METHODS Fifty patients seeking treatment of CBD who met the inclusion criteria were randomly assigned to either the experimental group (n = 25) or the control group (n = 25). Both groups received 4 sessions of psychoeducation. RESULTS Forty-four participants completed the follow-up with no differences in the rate of dropout between groups. There were no differences between participants who received topiramate or placebo in reducing CBD symptoms assessed by the primary outcome scale (Yale-Brown Obsessive-Compulsive Scale - Shopping Version). However, participants who received topiramate were significantly more likely to show clinical improvement when assessed by a secondary outcome measure, the Compulsive Buying Follow-Up Scale. In addition, there was a trend among participants who received topiramate to report improvements in aspects of hoarding and impulsivity compared with the control group. There were significant improvements in comorbid depression and social adjustments over time, but no group × time interaction was found. CONCLUSIONS The results do not provide support for the use of topiramate in the treatment of CBD. Future investigation with larger and representative samples and longer follow-up period are needed.
Biomedical Image Fusion : A Survey of The State of The Art

This article reviews the recent researches in the field of medical image fusion. Multi-modal medical image fusion algorithms have shown notable achievements in improving clinical accuracy of decisions based on medical images. Medical Image fusion is a useful tool for medical brain image classification and also for detecting the tumors in the earliest. This method is used to enhance the quality of images by combining two images of same scene obtained from different techniques, the objective is to reduce uncertainty and minimize maximizing relevant information particular to an application. In this review article, it is intended to summarize and compare the methods of image fusion techniques applied in medical image classification. In this review paper, an extensive comparative analysis is performed to provide the merits and demerits of various available techniques. This work also explores the applicability of the techniques in brain tumor diagnosis in Magnetic Resonance Images.
Comparison of Leukocyte-Rich Platelet-Rich Plasma and Leukocyte-Poor Platelet-Rich Plasma on Achilles Tendinopathy at an Early Stage in a Rabbit Model

Background: Tendinopathy is still a great challenge in clinical practice, and the role of platelet-rich plasma (PRP) is controversial. The influence of leukocytes on tendinopathy at an early stage has not been defined so far. Purpose: To compare the effects of leukocyte-rich PRP (Lr-PRP) and leukocyte-poor PRP (Lp-PRP) on Achilles tendinopathy when applied at an early stage. Study Design: Controlled laboratory study. Methods: A rabbit Achilles tendinopathy model was induced by a collagenase injection. A week later, treatments were applied randomly on local Achilles tendon lesions: (1) 200 μL of Lr-PRP (16 legs), (2) 200 μL of Lp-PRP (16 legs), and (3) 200 μL of saline (16 legs). At 3 and 6 weeks after the collagenase injection, outcomes were evaluated by histology, magnetic resonance imaging (MRI), real-time polymerase chain reaction analysis, immunohistochemistry, and transmission electron microscopy (TEM). Results: The Lr-PRP group had a lower T2 signal intensity (P = .0377) and smaller diameter (P = .0193) and cross-sectional area (P = .0194) than the Lp-PRP group on MRI. Histologically, the Lr-PRP group had better scores than the Lp-PRP group (P = .0284 and P = .0188, respectively). Compared with the Lp-PRP group, higher gene expression and more protein synthesis of collagen I (P = .0160 and P = .0309, respectively) and CD163 (P < .0001 and P = .0411, respectively) were found in the Lr-PRP group. Considering TEM and biomechanical testing, the Lr-PRP group demonstrated more mature collagen fibers (P < .0001), a larger fiber diameter (P = .0005), a higher failure load (P = .00417), and higher tensile stress (P < .0001) than the Lp-PRP group. Conclusion: Lr-PRP had more beneficial effects than Lp-PRP when delivered at an early stage during tendon repair. Clinical Relevance: Here, we showed that tendinopathy influenced the curative effects of PRP in vivo. An early-stage application of Lr-PRP had more benefits for the repair of tendinopathy than Lp-PRP in a rabbit model, which will supplement guidelines of PRP treatment on tendinopathy clinically.
ASSESSMENT OF RANGE PLANTS COMPOSITION ON SEMI-ARID ZONE OF NORTH DARFUR STATE, SUDAN

The research work was conducted at Alfashir locality for two consecutive seasons of 2012 and 2013 at three sites (Ummarahik 25km north of Alfashir, Fashar in eastern part of Alfashir about 5km and Berka 30km west of Alfashir) in semi-arid zone of North Darfur State. The aims of this study were to assess range components and species composition. Measurements of %plant, %litter, %bare soil, %feces or rocks and %species composition were assessed. The results showed the percentage of range components in different sites for two seasons; average plant composition was 52.33 and 68.04 for seasons 2012 and 2013, the average of %litter was (10.82%, 6.52%), bare soil (27.74%, 16.18%) and feces was (9.11, 9.26) for both seasons respectively. The species of highest composition was Aristida sp (26.75%, 26.56%) while species of Sesamum alatum had lowest percent (3.40%, 3.21%) for the seasons 2012 and 2013 respectively.The study concluded that unwise utilization and exploitation of the rangelands particularly by man causes range deterioration and serious reduction in range production in both quantity and quality, so, the study suggested that improvement and rehabilitation such lands rangelands should be done. Further research work is needed to assess rangeland attributes across different ecological zones in North Darfur State.
Effects of MEG-based neurofeedback for hand rehabilitation after tetraplegia: preliminary findings in cortical modulations and grip strength

Objective. Neurofeedback (NF) trains people to volitionally modulate their cortical activity to affect a behavioral outcome. We evaluated the feasibility of using NF to improve hand function after chronic cervical-level spinal cord injury (SCI) using biologically-relevant visual feedback of motor-related brain activity and an intuitive control scheme. Approach. The NF system acquired magnetoencephalography (MEG) data in real-time to provide feedback of event-related desynchronization (ERD) measured over the sensorimotor cortex during attempted hand grasping. During brain control, stronger ERD resulting from attempted grasping drove the virtual hand towards a more closed grasp, while less ERD drove the hand more open. Main results. Eight individuals with partial or complete hand impairment due to chronic SCI controlled the NF to perform a grasping task that increased in difficulty as the participants achieved success. During their first NF session, participants achieved an average success rate of 63.7 ± 6.4% (chance level of 13.9%). After as few as one intervention session, four of the seven individuals evaluated for ERD changes had significantly strengthened ERD and three of the four participants with measurable grip strength prior to NF had increased grip strength. Interestingly, both individuals who participated in a longer-term study (i.e. >8 NF sessions) had improved grip strength and significantly strengthened ERD. Significance. This study demonstrates that MEG-based NF training can change brain activity in individuals with hand impairment due to SCI and has the potential to induce acute changes in grip strength. Future studies will evaluate whether neuroplasticity induced with long term NF can improve hand function for those with moderate impairment.
The Socio-demographic correlates of utilization of antenatal care services by tribal women in North Eastern Region of India

Maternal health care services utilization by tribal women continues to be a major public health problem in India. Prior to the very existing of the national programmes for improving maternal and child health in NER, the maternal health care services still continue to be low among tribal women. Utilization of Ante natal care (ANC) services is poor in the rural areas, causing significant impact on the health of the tribal women. The fourth round of the DLHS 4 District Level Household and Facility Survey a nationwide survey which was conducted during 2012-13 is used for the analysis. A total of 12517 women were included in the study. Thus, of the total women covered more than half of the women had availed ante-natal care, i.e. (66.11%). Place of residence has been considered as important in determining any services utilization. This present study has revealed that association between predicator’s variables and health outcomes variables such as antenatal care were statistically significant. The study indicates that women of urban place of residence, higher level of education etc. have preferred to use the service more. The utilization of ANC were almost universal but were still low in rural areas and among tribal women.
COMPARISON BETWEEN TUMOR MARKER CEA, CA19-9 AND SOME MARKER ENZYMES (ALKALINE SPHINGOMYELINASE, CYCLOOXYGENASE-2, THYMIDYLATE SYNTHASE AND ARGINASE) IN SERUM OF COLON CANCER PATIENTS

Carcinoma of the colon was ranked as the sixth cancer among the top ten cancers in Iraq. Different markers are used for different purposes – namely, some of them are more appropriate for the follow-up of the disease and the others for the early detection of the disease recurrence. In many studies, an increase in CA 19-9 has been found to indicate a poor prognosis and high serum levels of either CEA or CA 19-9 in patients with colorectal cancer are significant, independent prognostic factors. Method: 104 patients diagnosed with colon cancer, period March 2013 to April 2014 from the patients treated in Mosul Oncology and Nuclear Medicine Hospital, Ten milliliters of venous blood was taken from each patient, then serum were separated for quantitative measurement of CEA and CA19-9 levels on mini VIDAS (Biomerieux, UK), Alk-SMase, COX2 and THYMS was determined by using ELISA. Arginase enzyme activity was determined according to (kocna et al., 1996) procedure. Results: The statistical analysis of data listed in table (18)show that there was significant difference (P˂0.05) of enzymatic activity for serum (Cyclooxygenase-2, and Arginase) which significantly increase (26.77 ±1.91 U/L, 23.3±2.50 ng/ml) respectively for patients with early stage A colon cancer compared with controls (12.57+1.65 U/L, 4.18±0.34 ng/ml) where as statistical analysis shows non significant increase (P˃0.05) with the levels of CEA and C19–9 tumor marker (4.04±1.6 ng/mL, 10.9±2.1 U/ml) respectively compared with controls (2.8±1.06 ng/mL, 7.2±1.7 U/ml) measured in stage A revealed that WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 6.041 Volume 5, Issue 4, 438-460 Research Article ISSN 2278 – 4357
Raising girls and boys in early China: Stable isotope data reveal sex differences in weaning and childhood diets during the eastern Zhou era

Abstract Objectives Using stable isotope analysis of incremental dentin segments, we reconstruct breastfeeding, weaning, and childhood dietary patterns of Eastern Zhou period (771–221 BC) individuals from the Central Plains of China. Previous isotopic research on the Eastern Zhou demonstrated dietary difference between male and female diets in adulthood via bone collagen analysis. To understand the development of gendered dietary patterns we must examine the early life period. We aim to identify the timing of the weaning process, whether childhood diets were the same as adulthood diets, and if there were differences between the diets of boys and girls during childhood. Materials and Methods We present incremental dentin and bone collagen δ13C and δ15N isotope data from 23 individuals from two Eastern Zhou archaeological sites (Xiyasi 西亚斯and Changxinyuan 畅馨苑). Results Weaning was completed between ages 2.5 and 4 years. Females were weaned slightly earlier than males. Early childhood diets show significant incorporation of C3 foods, such as wheat and soybean, for almost all children, while later adulthood diets indicate greater incorporation of C4 foods (millets), particularly for males. Discussion Childhood diets included greater amounts of C3 foods than expected, suggesting that grains such as wheat may have been adopted in these communities as foods for children. Nevertheless, dietary differentiation between females and males began in childhood, with boys eating more millets (C4 foods) than girls. The findings suggest that feeding children was a significant aspect of socialization and cultural gendering of individuals in ancient China.
Effect of Epoxidized Cottonseed Oil on Epoxy Resin and Its Thermal Behavior

In the present work the effect of loading of epoxidized cottonseed oil (ECO) on multifunctional epoxy and diglycidyl ether of bisphenol-A (DGEBA) were studied. First the epoxidized cottonseed oil was synthesized using peracetic acid. The modified network was obtained by blending ECO into epoxy resins having ECO content from 0 to 20 wt. %. The differential scanning calorimetry (DSC) determines the cross linking density of the neat and modified epoxy. The thermal degradation of both the epoxy materials was investigated using thermogravimetric analysis. The thermal stability decreased due to decrease in crosslinking density and increased due to high crosslinking. In multifunctional epoxy addition of epoxidized cottonseed oil enhances the chain mobility which decreases the thermal degradation temperature and cross-link density.
Satisfaction of Supplementary Insurance and Medical Services during Trips in War Survivors and their Families

Introduction: During trips the imposed costs are aggravated due to time and financial limits, not being familiar with treatment centers that are covered by the insurances and charges for accommodation. Insurance, especially supplementary treatment services insurance can be an appropriate solution to decrease these costs. These kinds of insurances cover a range of services including outpatient services to hospitalization and even sometimes unlimited services. The purpose of this study was to evaluate the satisfaction of war survivors and their families under the cover of supplementary insurance from medical care during trips. Methods: This study was cross-sectional descriptive. The size of studied population was 77 people from war survivors and their families who were assessed by a provided questionnaire in 2015. The including criteria was war survivors and their families under the cover of Veterans and Martyrs Affair Foundation (VMAF) and supplementary insurance war survivors. The prepared questionnaire included two sections; the first section was included the personal indications and the second section included satisfaction evaluations. Results: The prevalence of using medical care during trips in war survivors and their families was 2.72% and using medical care with supplemental insurance in trips was 1.5%. The obtained results from the questionnaires revealed that the highest satisfaction on medical care services and its distance belongs to the veterans' families with the mean of 4.57and 4.27, respectively. In the subject of taking back the costs, martyrs’ families were the least satisfied with the mean of 2.17. A significant relationship was found between sex and distance of the medical care services in trips (p=0.046). Men had more satisfaction compared to women. Finally it can be mentioned that there was not a significant relationship between client group and distance of medical care services during trips (p=0.067). Conclusion: According to the results, affording the costs and paying them back by the insurance company needs modifications.
A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population

Abstract MicroRNAs (miRNAs) play an essential role in gene expression and affect the development of tumours, including breast cancer (BC). Polymorphisms in miRNA genes can affect the interaction of miRNAs with their target messenger RNA by interfering, creating or disrupting target sites. The single nucleotide polymorphism (SNP) rs2910164, located in the seed region of miR146a, was shown to be associated with BC among different populations. In the present study, we investigated whether rs2910164 is associated with BC in 326 patients and 411 controls from a Brazilian population of predominantly European ancestry. The presence of the allele rs2910164*C was associated with an increased risk of BC (OR=1.4, 95% CI=1.03-1.85, p = 0.03). We also analysed publicly available RNA-seq data to evaluate if miR146a is differentially expressed in different subtypes of BC. Genotyping was performed by polymerase chain reaction with sequence-specific primers (PCR-SSP). By leveraging public data from TCGA database, we analysed 461 patients and found that miR146a is significantly more expressed in BC than in non-tumor tissue (1.47 fold, p = 0.02) and is expressed to a greater degree in aggressive BC subtypes.
Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth

Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin (PI) in the endoplasmic reticulum (ER) drive the molecular pathogenesis of mutant INS gene–induced diabetes of youth (MIDY). How these abnormal interactions are initiated remains unknown. Normally, PI-WT dimerizes in the ER. Here, we suggest that the normal PI-PI contact surface, involving the B-chain, contributes to dominant-negative effects of misfolded MIDY mutants. Specifically, we find that PI B-chain tyrosine-16 (Tyr-B16), which is a key residue in normal PI dimerization, helps confer dominant-negative behavior of MIDY mutant PI-C(A7)Y. Substitutions of Tyr-B16 with either Ala, Asp, or Pro in PI-C(A7)Y decrease the abnormal interactions between the MIDY mutant and PI-WT, rescuing PI-WT export, limiting ER stress, and increasing insulin production in β-cells and human islets. This study reveals the first evidence indicating that noncovalent PI-PI contact initiates dominant-negative behavior of misfolded PI, pointing to a novel therapeutic target to enhance PI-WT export and increase insulin production.
A Review Paper on Digital Mammography for Detection of Breast Cancer

Breast cancer is the second-most common and important cause of cancer death among women. It has become a major health problem in the world over the past 40-50 years, and its incidence has increased in recent years. Mammography is the best diagnosis technique for tumor detection. In this paper we define different techniques for early detection of breast cancer and also define analysis of classification of different method for detection of normal and abnormal tissue. This type of analysis is help to radiologists for better and early detection of cancer. So, we can reduce the mortality and also used for health care system. Key Word : Digital Mammography, Breast Cancer
Ultrasonic, Structural and Thermal Properties of LeadBorate Glasses

Glasses of the formula 68B2O3-(32-x)PbO-xBaO (0≤ x ≤ 12) were synthesized by standard melt quench technique and investigated their properties using XRD, ultrasonic, FT-IR and DTA studies. No sharp peaks are existing in the XRD spectra and the broad halo appeared around 2θ≈30, which reflects the characteristics of amorphous nature. Density decreases due to the replacement of higher molar mass by lower molar mass. The ultrasonic velocity varies with the gradual substitutions of barium ions in leadborate host glass matrix. The variations in elastic moduli such as L, G, K and E), Poisson’ sratio(), acoustic impedance(Z), microhardness (H) and Debye temperature (θD)were observed which resulted in compact glasses. The functional groups of prepared glasses were studied by FTIR analysis and BO4 structural units enhanced with decreasing BO3 structural units. Characteristic temperatures of DTA increase because of the higher bond strength of barium ions and also strength of the glasses. Kwywords :BPBa glasses, DTA, FTIR, Ultrasonic velocity
Synthesis of Silver Nanoparticles using Costusspeciosus and study of its anti-microbial properties against urinary tract pathogens

Infectious disease is the main cause of mortality in the world and the rapid increase of antibiotic resistance amongst pathogenic bacteria is becoming a serious public health problem. Antimicrobial resistance is becoming a factor in virtually all hospital acquired infections and it is expected that some bacterial infections may soon become untreatable in the near future. These concerns have led to major research efforts to discover alternative strategies that could be used to combat bacterial infections in patientsone of which is the use of nanotechnology.
Effect of different plant growth regulators on vegetative propagation of Bougainvillea peruviana cv

B.R. PARMAR Department of Horticulture, N.M. College of Agriculture, Navsari Agricultural University, NAVSARI (GUJARAT) INDIA ABSTRACT An experiment was conducted on “Effect of different plant growth regulators on vegetative propagation of Bougainvillea peruviana cv. TOUCH GLORY through hard wood cutting” and revealed that the various concentrations of IBA, NAA and their combinations, 4000 mg/l IBA proved the best for number of days taken for sprouting, in obtaining higher percentage of rooted cuttings, number of roots/cutting, length of root, number of shoots/cutting, length of shoot and survival per cent of rooted cuttings. IBA 3000 mg/l and IBA-2000 mg/l + NAA-2000 mg/l were also found superior in respect of root and shoot characters as well as survival percentage of rooted cuttings but they came next to IBA 4000 mg/l. The Asian Journal of Horticulture, (June, 2010) Vol. 5 No. 1 : 222-224 Research Paper