Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential drug-drug interactions in the neurology ward of a tertiary care hospital in Peshawar, Pakistan

Purpose : To identify and report the prevalence of potential drug-drug interactions (pDDIs) in a neurology ward, as well as their levels and association with risk factors. Methods : The study was conducted in the neurology ward of Northwest General Hospital Peshawar, Pakistan. Medical records of 205 randomly selected patients were retrospectively reviewed for potential drug-drug interactions using Micromedex Drug-Reax Software. Results : The total number of interactions identified were 633. About 96 % of the patients showed at least one type of potential interaction regardless of its severity. The identified pDDIs were categorized on the basis of severity, scientific evidence and onset. Based on severity, of the total of 633 pDDIs, 62.2 % were of major type while 31.8 % were of moderate type. On the basis of scientific evidence, 16.42 % were excellent type, 32.22 % in good category while fair category was the highest (55.60 %). The onset categories such as rapid (27.64 %), delayed (24.96 %) and non-specified onset (53.71 %) were also noted. Conclusion : Computerized DDIs programs are very helpful in minimizing harmful drug interactions. With this type of program, this better patient health outcomes can be achieved. Keywords : Drug-drug interaction, Patients, Drug reaction
The impact of a multi-component physical activity programme in low-income elementary schools

Objective: To identify the effects of a structured and multifaceted physical activity and recess intervention on student and adult behaviour in school. Design: Mixed-methods and community-based participatory approach. Setting: Large, urban, low-income school district in the USA. Methods: Data were collected at three time points over a 1-year period. Sources included recess observations at four elementary schools, in-class behavioural observations of fifth-grade students (n = 21) and focus groups with fourth- and fifth-grade students (n = 75). Results: Results suggested an increased amount of positive interactions between adults and students and a decreased amount of conflict in the playground post intervention. Results also suggested that a peer-leadership training programme had beneficial effects on students’ classroom behaviour. Conclusion: Results from this study provide evidence that school recess can be used to teach social–emotional competencies that can impact student behaviour during recess and in the classroom.
‘I have so little time […] I got shit I need to do’: Critical perspectives on making and sharing in Manchester’s FabLab

This paper argues for rethinking the economic geography of sharing and making in light of the recent proliferation of open innovation, makerspaces and maker movements. Using empirical research from an example of one such makerspace – Manchester’s FabLab – and engaging with a range of geographical literatures on making, sharing economies, and digital fabrication, we develop a critical account of sharing in principle and in practice. The portrayal of open innovation spaces, such as FabLabs, as novel makerspaces of alterity and sharing is a common and underpinning theme in both academic and marketing literature (Aldrich, 2014; Anderson, 2012; Doherty, 2012; Fab Foundation, 2012; Gershenfeld, 2005; Suire, 2019). However, our findings suggest that the values espoused by the FabLab, of involvement, connection and affinity, are quite literally being revised and rejected by makers who use the space. Time, labour and knowledge were for the most part described by participants as precious commodities to be savoured rather than shared. Thus, while sharing is an ordinarily economic practice, this does not mean it is always, inevitably or evenly employed by economic actors and communities, especially within counter-cultural networks. If these are to be the economies of the future, we implore economic geographers to critically engage further with the complexities of and within maker spaces.
Women dentists: Changing the face of dentistry

It was only toward the close of the last century that women emancipated themselves from their former small territory of usefulness in a strictly domestic life, and pushing forward, proved themselves often the business equal to men and sometimes their superior. If was long before this progression, when a women in business or professional ranks was almost a curiosity. When women first entered the profession, they faced many obstacles. Mentors or faculty in the dental organizations majority were male restraining women by all means. In the beginning, men were resentful because they feel women are inferior. It took a long time for women to become a consistent presence in dental schools. In the beginning, dental schools used to admit one or two women each year, later the number increased slowly. Olden day′s women used to relieve not even the tooth ache but also used to relieve others fret also. But histories of dentistry were not acknowledged the talent of women whatsoever. The efforts and achievements of women punch the clock in the future dentistry. The current scenario has totally changed now. Nearly, half of all dental students′ are women and 25% of them are practicing dentists. Only 3% women dentists were there before the 1970s. [1] Women struggled to obtain a degree, to establish practices, and are respected as professionals. Some women choose this rewarding occupation as career followed by their family members. The population tally of chosen work upbringing has changed over time. This paper reports in a delineative way of the amelioration, staggering presence, and intendment of dentistry practicing by worldwide women.
Semi‐auto horizon tracking guided by strata histograms generated with transdimensional Markov‐chain Monte Carlo

Although horizon interpretation is a routine task for building reservoir models and accurately estimating hydrocarbon production volumes, it is a labour‐intensive and protracted process. Hence, many scientists have worked to improve the horizon interpretation efficiency via auto‐picking algorithms. Nevertheless, the implementation of a classic auto‐tracking method becomes challenging when addressing reflections with weak and discontinuous signals, which are associated with complicated structures. As an alternative, we propose a workflow consisting of two steps: (1) the computation of strata histograms using transdimensional Markov‐chain Monte Carlo and (2) horizon auto‐tracking using waveform‐based auto‐tracking guided by those strata histograms. These strata histograms generate signals that are vertically sharper and more laterally continuous than original seismic signals; therefore, the proposed workflow supports the propagation of waveform‐based auto‐picking without terminating against complicated geological structures. We demonstrate the performance of the novel horizon auto‐tracking workflow through seismic data acquired from the Gulf of Mexico, and the Markov‐chain Monte Carlo inversion results are validated using log data. The auto‐tracked results show that the proposed method can successfully expand horizon seed points even though the seismic signal continuity is relatively low around salt diapirs and large‐scale faults.
Prevalence of Mental Disorders among adolescents of secondary schools in Diwaniya governorate

- A cross-sectional study was conducted , on 1048 adolescent pupils(554 male &494 female) , in Al-Diwaniya Governorate , Iraq. -Twelve intermediate and secondary schools were chosen consecutively as a study setting ( 6 from Diwaniya city as urban ; 3 from Shamiya &3from Gammas as rural). -All chosen pupils (aged 12â€“18years) were considered in the self reporting questionnaire & face to face interview during the period from the 1st of May to the 30th of November 2010. -Out of 1048 adolescents assessed, 183 have positive mental disorders, giving a point prevalence of 17.46% . -Among the examined pupils are (79) diagnosed with anxiety disorders which represent about 7.5% of the total adolescents under study, (41) with a depressive disorders which represent about 3.91% , (36)diagnosed with behavioral disorders which represent about 3.43% , and (27) with ADHD which represent about 2.57% of the total adolescentsunder study.
Rising advancements in the application of PEDOT:PSS as a prosperous transparent and flexible electrode material for solution-processed organic electronics

ABSTRACT An organic conductive polymer, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), is an attractive candidate for a low-cost, low-temperature, and solution-processed electrode material for achieving high-performance flexible and stretchable thin-film devices. Unlike most organic materials, this water-soluble conjugated polymer is highly stable against chemical and physical exposure. It exhibits the most superior mechanical flexibility and the highest optical transparency and electrical conductivity among all organic conductors. Therefore, this conductive polymer is among the most promising alternatives to the expensive, rigid, and brittle metal oxide- and even metal-based electrode materials, such as indium tin oxide (ITO) and gold, in the future solution-processed electronic devices. Nevertheless, the intrinsic conductivity of PEDOT:PSS is typically below 1 S cm−1, which is too low for such devices. Fortunately, the material properties of PEDOT:PSS, including its conductivity, are easily tuned by employing a large number of simple approaches. In this paper, the reports on the successful application of PEDOT:PSS to a wide range of solution-processed organic devices, such as organic light-emitting diodes (OLEDs), organic thin-film transistors (OTFTs), and organic photovoltaics (OPVs), are reviewed. The recent progress in the development of highly conductive PEDOT:PSS-based films for electrode applications in the field of organic electronics is the main focus of the discussion herein.
How populist crisis rhetoric affects voters in Switzerland

Right-wing populism has a long tradition in Switzerland. Nevertheless, only little is known about how populist messages in the media contribute to the success of the Swiss People’s Party (SVP) and to the acceptance of the party’s anti-immigration policies. In this study, we combine data from a large media content analysis (including newspapers and TV news shows) with data from a panel-survey in order to address this research gap. Thereby we differentiate between effects driven by the content and the form of right-wing populist communication. While right-wing populist content depicts immigrants and the political elite as a threat to the Swiss people, populist style evokes the sense of a crisis by emotionalizing and dramatizing the message. Populist style is therefore assumed to increase the persuasiveness of populist claims. The results of this study suggest that this is the case only for some voters, while it backfires for others.
Weed vegetation of arable land in Slovakia: diversity and species composition

Arable fields are among the most widespread habitats in Slovakia, but recently, there have been no studies regarding species composition and structure of weed vegetation in these fields. Therefore, we studied the structure of arable weed vegetation and detected α- and β-diversity. The dataset of 507 phytosociological releves in different crop types contains 407 plant taxa in 46 plant families. Native plants dominated over aliens, archaeophytes dominated over neophytes, and 14 plants belonged to invasive taxa. The most common species in the dataset were Tripleurospermum perforatum , Cirsium arvense , and Viola arvensis . Weeds were mostly therophytes, b- and a-euhemerobic, competitors, and ruderals, reproducing by seeds and pollinated by insects. The β-diversity of weed vegetation decreased with elevation and temperature and was higher in the Pannonicum than the Carpaticum region. The highest β-diversity was established in fodder+fallow fields, followed by that in cereals and root-crop fields, and the smallest diversity was found in stubble. Beta-diversity increased from spring to summer and slightly decreased again in fall. Detrended correspondence analysis indicated that the major compositional turnover of weed vegetation was related to light, temperature, moisture, and elevation. Weed vegetation constitutes an important habitat in the landscape that provides refuge to many threatened plants, and this vegetation has important functions in the agro-ecosystem food chain.
Friction modelling in sheet metal forming simulations for aluminium body parts at Daimler AG

Tribology plays a key role in the production of high-quality car body parts. In forming simulations, often a constant value for the friction coefficient is used, which limits the overall simulation accuracy. In reality, friction depends on the pressure distribution, forming velocity, interface temperature, plastic strain, type/amount of lubrication and the surface topography of both the sheet and the tooling. The simulation accuracy, and therefore the prediction of the formability of complex geometries, can be improved significantly by taking all these parameters into account. This paper presents a selection of results for 2 aluminium cases: 1 scientific part conducted at the IFU Stuttgart and 1 complex body part from Daimler AG. Simulation results have been validated by experimental results to show the influence of friction on e.g. part quality, draw-in and spring-back. Results show that friction modelling becomes increasingly important in the stamping process of aluminium parts, and that the overall simulation accuracy increases when accounting for the actual tribological conditions in stamping.
Pathogenetic role of Staphylococcus aureus in purulent keratoconjunctivitis in cats

The research was carried out in the Department of Surgery and Obstetrics of Agricultural Animals of Dnipro State Agrarian and Economic University on clinically healthy outbred cats of different ages with purulent keratoconjunctivitis. Hematological, biochemical and immunological parameters were determined in the animals, and microbiological and virological research was conducted on them. According to the data obtained, more than half of cases of ophthalmopathology in cats were conjunctivitis and keratoconjunctivitis, and they were more often registered in the cold season. The main causes of eye diseases in the cats were mechanical injuries, coccal and chlamydial infection, allergy and development of disease against the background of primary lesions of the ears and paranasal sinuses. Among the detected microorganisms, the vast majority (81.9%) were staphylococci, including S. albus, S. aureus and S. epidermidis. All types of microorganisms except O-forms of Bacillus sp. exhibited high and medium sensitivity to antibiotics. Immunoblotting revealed polypeptides that responded to specific S. aureus antigens in samples of conjunctiva, cornea, intraocular fluid, and blood of cats suffering from purulent (staphylococcal) keratoconjunctivitis. The highest antigen concentration was detected in the cornea and conjunctiva. In the absence of expressive shifts of the investigated hematological and biochemical parameters, the dynamics of immunological markers were shown by a significant increase in the content of immunoglobulins and circulating immune complexes, as well as by a distinct activation of the complement system by the classical route. The results showed a clear gradual activation of phagocytosis, namely: the number of phagocytic neutrophils increased, reaching its maximum value by the seventh day of development of purulent keratoconjunctivitis. The phagocytic index in the first three days of observation tended to decrease, and by the seventh day it had already significantly exceeded the initial value. Despite the ambiguous dynamics of the phagocytic index, in the course of the development of the inflammatory process in the blood of sick cats, we observed a clear increase in the index of complete phagocytosis. Thus, the development of purulent keratoconjunctivitis in cats occurs against the background of clear cellular and humoral responses to the infectious agent.
Non-Uniform Impact of Fiscal Decentralization on Economic Growth: A State Level Analysis in India

In this paper, I examine the impact of fiscal decentralization on state-level economic growth in India. There is little empirical evidence testing for a non-uniform impact of fiscal decentralization within a country. I build a social development index (SDI) to characterize 15 Indian states into developed and under-developed, based on their education and health outcomes. Using an analytical model, I identify the specific channels through which fiscal decentralization impacts economic growth. My results suggest that, while both expenditure and revenue decentralization strongly impact economic growth positively, developed states only show a small effect. Further, looking at specific aspects of expenditure and revenue decentralization lend support to a non-uniform impact of fiscal decentralization on growth across states in India. These findings call for a re-evaluation of the center-state fiscal arrangements and have important implications for policy.
The Influence of Management Control System, Encouragement of Environmental Management, and Proactive Environmental Management on Carbon Emission Efficiency

The efficiency of carbon emissions in the production process contributes significantly to restrain the rate of global warming, and it is strongly correlated with industrial behavior. Therefore, this research was done to explore the dominant factors that influence the behavior of carbon emissions efficiency. The population in this study was manufacturing companies in Central Java, which have been classified by the industrial office of Central Java in 2007. This research used a purposive sampling technique and Multiple Linear regression analysis techniques to examine the factors that influence the behavior of carbon emissions efficiency. The results showed that three dominant factors that influence the behavior of carbon emissions efficiency are the encouragement of environmental management, proactive environmental management, and management control system. Based on this research, management control practice and policies of carbon emission efficiency can be formulated by appropriate authorities.
Integration of metabolomics and transcriptomics provides insights into enhanced osteogenesis in Ano5Cys360Tyr knock-in mouse model

Introduction Gnathodiaphyseal dysplasia (GDD; OMIM#166260) is a rare autosomal dominant disorder characterized by diaphyseal sclerosis of tubular bones and cemento-osseous lesions in mandibles. GDD is caused by point mutations in the ANO5 gene. However, the mechanisms underlying GDD have not been disclosed. We previously generated the first knock-in mouse model for GDD expressing a human mutation (p.Cys360Tyr) in ANO5 and homozygous Ano5 knock-in (Ano5KI/KI ) mice exhibited representative traits of human GDD especially including enhanced osteogenesis. Methods Metabolomics and transcriptomics analyses were conducted for wildtype (Ano5+/+ ) and Ano5KI/KI mature mouse calvarial osteoblasts (mCOBs) grown in osteogenic cultures for 14 days to identify differential intracellular metabolites and genes involved in GDD. Subsequently, related differential genes were validated by qRT-PCR. Cell proliferation was confirmed by CCK8 assay and calcium content in mineral nodules was detected using SEM-EDS. Results Metabolomics identified 42 differential metabolites that are primarily involved in amino acid and pyrimidine metabolism, and endocrine and other factor-regulated calcium reabsorption. Concomitantly, transcriptomic analysis revealed 407 differentially expressed genes in Ano5KI/KI osteoblasts compared with wildtype. Gene ontology and pathway analysis indicated that Ano5Cys360Tyr mutation considerably promoted cell cycle progression and perturbed calcium signaling pathway, which were confirmed by validated experiments. qRT-PCR and CCK-8 assays manifested that proliferation of Ano5KI/KI mCOBs was enhanced and the expression of cell cycle regulating genes (Mki67, Ccnb1, and Ccna2) was increased. In addition, SEM-EDS demonstrated that Ano5KI/KI mCOBs developed higher calcium contents in mineral nodules than Ano5+/+ mCOBs, while some calcium-related genes (Cacna1, Slc8a1, and Cyp27b1) were significantly up-regulated. Furthermore, osteocalcin which has been proved to be an osteoblast-derived metabolic hormone was upregulated in Ano5KI/KI osteoblast cultures. Discussion Our data demonstrated that the Ano5Cys360Tyr mutation could affect the metabolism of osteoblasts, leading to unwonted calcium homeostasis and cellular proliferation that can contribute to the underlying pathogenesis of GDD disorders.
Avaliação do comportamento e da tendência pluviométrica na Amazônia Legal no período de 1986 a 2015

Amazonia desperta interesse no meio cientifico por ter a maior floresta tropical do mundo, com grande disponibilidade hidrica e de energia solar, fundamental para regulamentacao do clima regional e global. Neste contexto esta pesquisa analisa o comportamento pluviometrico anual e sazonal da Amazonia Legal no periodo de 30 anos (1986 a 2015), atraves de dados de 268 estacoes pluviometricas disponibilizados na rede hidrometeorologica (HidroWeb) da Agencia Nacional de Aguas (ANA), para contribuir como subsidio para gestao e planejamento dos recursos hidricos desta regiao. A dinâmica espacial e temporal da precipitacao foi analisada atraves da elaboracao dos mapas de isoietas atraves da interpolacao de krigagem ordinaria linear, a estimativa da precipitacao media pelo metodo de isoietas e a estimativa do volume precipitado pelo metodo dos contornos. A regionalizacao foi analisada por meio do metodo de agrupamento hierarquico de Ward e a tendencia e magnitude pelos testes nao parametricos de Mann Kendall e Sen’s, respectivamente. Os resultados indicam precipitacao anual media de 2.070 mm, corresponde a 5,67 mm/dia, contudo ha uma ampla variacao no comportamento pluviometrico espacial crescente no sentido do sul para o norte e tambem variacao temporal, tanto no interanual como no sazonal. Com a regionalizacao da precipitacao anual e das coordenadas geograficas latitude e longitude tres regioes evidenciam os diferentes padroes pluviometricos com variacoes na precipitacao media, tendo a regiao sul media de 1.733 mm/ano, a leste de 1.561 mm/ano e a norte de 2.390 mm/ano, e coincide com os principais sistemas atmosfericos atuantes. Assim como, na regionalizacao da precipitacao mensal verificou-se que o comportamento sazonal varia bastante entres as regioes, como mostra a normal climatologica, a parti dos periodos chuvosos, transicao e menos chuvosos. Os testes estatisticos indicam tendencias e magnitudes pontuais tanto positivas como negativas para a precipitacao anual e mensal, estatisticamente significativa para o nivel de significância de 5%. Porem, estima-se uma taxa media decrescente de 5 mm ao ano na precipitacao da area de estudo. Portanto, conclui-se que o comportamento pluviometrico nao e homogeneo, influenciado pelos sistemas e fenomenos atmosfericos, sobretudo pelos eventos La Nina e El Nino forte. Contudo, tres regioes homogeneas demonstram os principais padroes pluviometricos, mas para obter regioes mais similares indica-se um numero maior de regioes homogeneas, pois trata-se de uma regiao extensa e com ampla variabilidade pluviometrica. Aonde mudancas importantes estao acontecendo no comportamento pluviometrico, podendo acarretar risco hidrologico e climatico.