Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanisms of immune-related differentially expressed genes in thyroid-associated ophthalmopathy based on the GEO database

Background We performed a differential analysis, enrichment analysis, and immune-infiltration analysis of the thyroid-associated ophthalmopathy (TAO) gene using data from the Gene Expression Omnibus (GEO) database to provide a theoretical basis for understanding the immune-related mechanisms of TAO. Methods We searched the GEO database for “Graves disease” and selected the genes expressed in the lacrimal gland of thyroid-related eye disease patients as the test group and the genes expressed in the lacrimal gland of normal subjects as the control group. Immune-related differentially expressed genes (irDEGs), gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, protein-protein interaction, gene-gene interaction (GGI) network, pivotal gene identification, and immune-infiltration analyses were carried out, and finally, risk-prediction models were constructed. Results The GSE105149 and GSE58331 data sets contained 200 DEGs, of which 15 were immune-related. In relation to the GO biological processes (BPs), the main pathways included the interleukin (IL)-27-mediated signaling pathway, the IL-35-mediated signaling pathway, cytokine activity, T helper 17 cell differentiation, the phosphatidylinositol-3-kinase and protein kinase B signaling pathway, cytokine-cytokine receptor interaction, the Janus kinase and signal transducer and activator of transcription signaling pathway, and other KEGG pathways. Cluster of differentiation (CD)4+ T cells, monocytes, M0 macrophages, and Mast cells were significantly elevated in TAO, while M2 macrophages were significantly reduced. In the immune cell correlation analysis, CD4+ T cells and naïve B cells were significantly positively correlated with activated natural killer (NK) cells, and Mast cells were positively correlated with plasma cells and negatively correlated with M2 macrophages. Risk models for a total of 6 genes (i.e., Janus kinase 1, heat shock protein 90-α, phospholipase A 2 group IIA, fibroblast growth factor 3, glucose-6-phosphate isomerase, and protein disulfide isomerase family A, member 2), were constructed, and over 100 potential targeted therapeutic agents were obtained. Conclusions In TAO, various types of immune cells infiltrate to different degrees, and the immune response and inflammatory response are throughout the disease. Our constructed risk-prediction models provide a reference for predicting TAO.
COVID-19: Knowledge, Attitudes, and Practices among the Scholarly Cohorts of Nepal

COVID-19 is an infectious disease caused by a newly discovered microorganism called corona virus, a pandemic. Knowledge, attitudes and practices are prime components that play a crucial role in spreading the disease. These elements would support focusing on the people with underlying medical problems, and old-aged people, including children, are more likely to be susceptible. The main objective of this study was to assess the knowledge, attitude, and practices amongst the students, teachers, and health workers, including staff members of the NGOs/INGOs. This cross-sectional study was done, including 224 respondents. A self-administered-structured questionnaire comprised of nineteen structured questions exploring the pandemic’s knowledge, attitudes and practices was done. The data were analyzed using the Statistical Package for the Social Sciences (SPSS) software version 25.0. Of the total, 67.4% were males, and 32.6% were females. Nearly 50% of the respondents were with M-Phil/PhD degrees, while 4.9% had a secondary level. The study revealed that 28.0% of the participants knew about the pandemic, 41.0% had positive attitudes, and 54.0% experienced good practices. The knowledge level on the pandemic was statistically significant where attitudes and practices were poor. This study suggests that public health approaches such as awareness, masseducation campaigns, etc., are urgently required to control the outbreaks strongly associated with the community’s knowledge, attitudes, and behaviours.
High quality interventions that reduced the overall number of frequent emergency department visitors for pain-related complaints

Background: Pain is one of the most common complaints that patients present to the emergency department for; emergency medicine providers are tasked with providing appropriate pain relief while simultaneously limiting the risk of personal and societal harm that may result from opioid misuse. The Lakeland Regional Medical Center developed a medical management program that identified frequent emergency department visitors with a chief complaint of pain. Individualized care plans were developed for these patients. Summary: Generation and dissemination of care plans led to a decrease in emergency room visits and hospital admissions. The authors describe their experience with a quality improvement initiative that identifies frequent emergency department visitors with a chief complaint of pain and provides individualized care plans to these patients. The goals of the program are to improve patient's quality and consistency of care, through interventions that eliminate the prescribing of opioids while providing non-opioid alternatives.
An improved upper bound on the diameters of subset partition graphs

In 1992, Kalai and Kleitman proved the first subexponential upper bound for the diameters of convex polyhedra. Eisenbrand et al. proved this bound holds for connected layer families, a novel approach to analyzing polytope diameters. Very recently, Todd improved the Kalai-Kleitman bound for polyhedra to $(n-d)^{1+\log_2d}$. In this note, we prove an analogous upper bound on the diameters of subset partition graphs satisfying a property related to the connectivity property of connected layer families.
ORGANIZATIONAL SOCIALIZATION APPLICABILITY, MEASUREMENTS, AND THEORIES: A SYSTEMATIC REVIEW AND GUIDELINE FOR FUTURE RESEARCH

Motivated by the growing literature on organizational socialization (OS), this study aims to provide a review of the domain of organizational socialization in the workplace, highlighting the applicability of OS, the most used measures, the mechanisms of OS, commonly used theories, and future directions. Using a systematic literature review, the search was conducted using Web of Science and covering the years 1991 to 2021. After removing qualitative and unrelated studies, we reached 24 articles published in the Financial Times research rank.
Convergence and stability in balanced norms of finite element methods on Shishkin meshes for reaction‐diffusion problems

Error estimates of finite element methods for reaction‐diffusion problems are often realized in the related energy norm. In the singularly perturbed case, however, this norm is not adequate. A different scaling of the H1 seminorm leads to a balanced norm which reflects the layer behavior correctly. We prove error estimates in balanced norms and investigate also stability questions. Especially, we propose a new C0 interior penalty method with improved stability properties in comparison with the Galerkin FEM.
Identification of Cell-and Disease-Specific Micro RNAs in Glomerular Pathologies

Background: MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression in physiological processes as well as in diseases. Currently miRs are already used to find novel mechanisms involved in diseases and in the future, they might serve as diagnostic markers. To identify miRs that play a role in glomerular diseases urinary miR-screenings are a frequently used tool. However, miRs that are detected in the urine might simply be filtered from the blood stream and could have been produced anywhere in the body, so they might be completely unrelated to the diseases. Methods: We performed a combined miR-screening in pooled urine samples from patients with different glomerular diseases as well as in cultured human podocytes, human mesangial cells, human glomerular endothelial cells, and human tubular cells. The miR-screening in renal cells was done in untreated conditions and after stimulation with TGF-β. Results: A merge of the detected regulated miRs led us to identify disease-specific, cell type-specific and cell stress-induced miRs. Further, urinary miRs from patients with different glomerular diseases could be assigned to the different renal cell types. Conclusion: Thus, a combined urinary and cell miR-screening can improve the interpretation of screening results. These data are useful to identify novel miRs potentially involved in glomerular diseases.
Multiplicity and transverse evolution of charge-dependent correlations in pp, and collisions at the LHC.

We report on two-particle charge-dependent cor-relationsinpp,p–Pb,andPb–Pbcollisionsasafunctionofthe pseudorapidity and azimuthal angle difference, (cid:3)η and (cid:3)ϕ respectively. These correlations are studied using the balance function that probes the charge creation time and the development of collectivity in the produced system. The dependence of the balance function on the event multiplicity as well as on thetrigger andassociatedparticletransversemomentum ( p T ) in pp, p–Pb, and Pb–Pb collisions at √ s NN = 7, 5.02, and 2.76 TeV, respectively, are presented. In the low transverse momentum region, for 0 . 2 < p T < 2 . 0 GeV/ c , the balance function becomes narrower in both (cid:3)η and (cid:3)ϕ directions in all three systems for events with higher multiplicity. The experimental ﬁndings favor models that either incorporate some collective behavior (e.g. AMPT) or different mechanisms that lead to effects that resemble collective behavior (e.g. PYTHIA8 with color reconnection). For higher values of transverse momenta the balance function becomes even narrower but exhibits no multiplicity dependence, indicating that the observed narrowing with increasing multiplicity at low p T is a feature of bulk particle production.
Interlayer tunneling spectroscopy and doping-dependent energy-gap structure of the trilayer superconductor Bi2Sr2Ca2Cu3O10+delta

The superconducting gap, the pseudogap, and their doping and temperature dependences have been measured by the short-pulse interlayer tunneling spectroscopy for the CuO 2 triple-layer high-T c superconducting Bi 2 Sr 2 Ca 2 Cu 3 O 1 0 + δ system. It is found for a nearly optimally doped sample that the superconducting gap magnitude is 80 meV and the pseudogap is 120 meV, the values of which are slightly larger than those for CuO 2 double-layer system. Both gap magnitudes show a clear tendency to decrease with increasing doping. In an underdoped sample, a clear dip-and-hump structure is observed, which declines with increasing doping and tends to diminish in overdoped samples. The relationship between unchanged T c and decreasing superconducting gap in the overdoped region is discussed in terms of the proximity effect applied to the inequivalent doping model. We also discuss the dip-and-hump structure in comparison with other spectroscopic results. Finally, we argue an important implication of the increasing maximum Josephson current and the decreasing superconducting gap magnitude, both with increasing doping.
Determine TB –LAM Lateral Flow Assay, Does M. tuberculosis lineage influence its performance? CURRENT STATUS: POSTED

The World Health Organization conditionally recommended the Determine lateral flow TB-LAM (LF-LAM) assay for tuberculosis diagnosis. The test is recommended for diagnosis and screening of active tuberculosis among HIV-infected individual’s adults with signs and symptoms of TB (pulmonary and/or extra pulmonary) with CD4 cell count less than or equal to 100 cells/mm3 or HIV-positive patients who are seriously ill, regardless of CD4 cell counts. However, the effect of MTB genetic diversity to the performance of LF-LAM remains unknown. We determined the perfomance of the against M. tuberculosis (MTB) lineages among HIV-positive individuals with pulmonary and/or MTB-bacteremia. We compared Our study show that L3 may have more specificity for LF-LAM assay than L4. Regional diversity in performance of LF-LAM assay may occur depending on the dorminat MTB lineage. Future studies on a large sample size with more MTB-lineage diversity are recommended.
THE MARKET’S REACTION TO THE BASEL IV ANNOUNCEMENT

School of Business, Economics and Law Master of Science in Finance The Market’s Reaction to the Basel IV Announcement Stricter capital requirement for banks is one of the key measures to make the banking system more resilient and eventually counteract financial crises. Established by the Basel Committee on Banking Supervision (BCBS) since 1988, the Basel Accords are a series of regulatory acts of bank capital requirements. These accords, which require banks to keep a certain level and quality of capital, have become both recognized and criticized. However, BCBS continues to increase requirements on capital. In 2016 and 2017, the strictest version of the accords were announced through the establishment of Basel IV. While investigating the market movements triggered by Basel IV, this study examines the void of how stricter capital requirements impact banking performance with an event study methodology. The findings demonstrate a minor negative effect on banking performance during the announcement of Basel IV. However, the results do not yield any statistical significance, a result that could very well be an indication of the opaqueness of the capital requirement or simply because the market did already internalize the effects of Basel IV before the announcement.
Drivers for the Willingness of Small and Medium Enterprise in Implementing Halal Supply Chain Management

This study investigates the role of consumer concern, supplier readiness, and government initiative in determining the willingness of halal SME to deploy halal SCM. The hypotheses were assessed by using mail survey conducted in Malaysia in 2017. The empirical data use 172 data obtained from small and medium enterprise. Reliability and validity of the item is assessed through Cronbach alpha and factor analysis. To test the hypotheses, structural equation modelling by partial least square was adopted. The study finds that consumer concern plays a crucial role in determining the willingness to implement halal SCM. The supplier readiness can play important role in influencing halal SME to implement halal SCM. Finally, this study revealed that the important of government initiatives is significantly influenced halal SME to implement halal SCM in the operational activity.
Synthesis and Characterization of p-n Junction Ternary Mixed Oxides for Photocatalytic Coprocessing of CO 2 and H 2 O

: In the present paper, we report the synthesis and characterization of both binary (Cu 2 O, Fe 2 O 3 , and In 2 O 3 ) and ternary (Cu 2 O-Fe 2 O 3 and Cu 2 O-In 2 O 3 ) transition metal mixed-oxides that may ﬁnd application as photocatalysts for solar driven CO 2 conversion into energy rich species. Two di ﬀ erent preparation techniques (High Energy Milling (HEM) and Co-Precipitation (CP)) are compared and materials properties are studied by means of a variety of characterization and analytical techniques UV-Visible Di ﬀ use Reﬂectance Spectroscopy (UV-VIS DRS), X-ray Photoelectron Spectroscopy (XPS), X-Ray Di ﬀ raction (XRD), Transmission Electron Microscopy (TEM), and Energy Dispersive X-Ray spectrometry (EDX). Appropriate data elaboration methods are used to extract materials bandgap for Cu 2 O@Fe 2 O 3 and Cu 2 O@In 2 O 3 prepared by HEM and CP, and foresee whether the newly prepared semiconductor mixed oxides pairs are useful for application in CO 2 -H 2 O coprocessing. The experimental results show that the synthetic technique inﬂuences the photoactivity of the materials that can correctly be foreseen on the basis of bandgap experimentally derived. Of the mixed oxides prepared and described in this work, only Cu 2 O@In 2 O 3 shows positive results in CO 2 -H 2 O photo-co-processing. Preliminary results show that the composition and synthetic methodologies of mixed-oxides, the reactor geometry, the way of dispersing the photocatalyst sample, play a key role in the light driven reaction of CO 2 –H 2 O. This work is a rare case of full characterization of photo-materials, using UV-Visible DRS, XPS, XRD, TEM, EDX for the surface and bulk analytical characterization. Surface composition may not be the same of the bulk composition and plays a key role in photocatalysts behavior. We show that a full material knowledge is necessary for the correct forecast of their photocatalytic behavior, inferred from experimentally determined bandgaps.
Edinburgh Research Explorer Down-regulation of 14-3-3 zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation

The family of 14-3-3 proteins has emerged as critical regulators of diverse cellular responses under both physiological and pathological conditions. Here, we report an important role of 14-3-3 (cid:1) in tumori-genesisthroughamechanismthatinvolvesanoikisresistance.14-3-3 (cid:1) is up-regulated in a number of cancer types, including lung cancer. Through an RNAi approach using human lung adenocarcinoma-derivedA549cellsasamodelsystem,wehavefoundthatknockdown of a single (cid:1) isoform of 14-3-3 is sufﬁcient to restore the sensitivity of cancer cells to anoikis and impair their anchorage-independent growth. Enhanced anoikis appears to be mediated in part by up-regulated BH3-only proteins, Bad and Bim, coupled with decreased Mcl-1, resulting in the subsequent activation of Bax. This study suggests a model in which anchorage-independent growth of lung cancer cells requires the presence of 14-3-3 (cid:1) . This work not only reveals a critical role of 14-3-3 (cid:1) in anoikis suppression in lung cancer cells, but also identiﬁes and validates 14-3-3 (cid:1) as a potential molecular target for anticancer therapeutic development. threshold for the activation of Bax. Our work not only reveals an important role of 14-3-3 (cid:7) in the suppression of anoikis, but also validates 14-3-3 (cid:7) as a potential molecular target for the development of anticancer agents. This 14-3-3 (cid:7) -targeted strategy is sup-ported by recent clinical data that associate 14-3-3 (cid:7) expression with advanced disease grade and poor survival outcome of lung cancer patients (41).
Isolation and Characterization of Lytic Bacteriophages Specific for Campylobacter jejuni and Campylobacter coli

In this study, two lytic bacteriophages designated as vB_CjP and vB_CcM were isolated and evaluated for their ability to combat multidrug-resistant bacteria Campylobacter jejuni and Campylobacter coli, respectively. A morphological analysis of these phages by transmission electron microscopy revealed that the vB-CjP bacteriophage had a mean head dimension of 66.6 ± 2.1 nm and a short non-contractile tail and belongs to the Podoviridae family, whereas vB_CcM had a mean head dimension of 80 ± 3.2 nm, a contractile tail, and a length calculated to be 60 ± 2.5 nm and belongs to the Myoviridae family. The results of the host range assay showed that vB_CjP could infect 5 of 10 C. jejuni isolates, whereas vB_CcM could infect 4 of 10 C. coli isolates. Both phages were thermostable and did not lose their infectivity and ability to lyse their host following exposure to 60 °C for 10 min; furthermore, phage particles were relatively stable within a pH range of 6–8. A one-step growth curve indicated that the phages produced estimated burst sizes of 110 and 120 PFU per infected cell with latent periods of 10 and 15 min, for vB-CjP and vB-CcM, respectively. The lytic activity of these phages against planktonic Campylobacter showed that these phages were able to control the growth of Campylobacter in vitro. These results suggest that these phages have a high potential for phage applications and can reduce significantly the counts of Campylobacter spp. The lytic activity of vB-CjP and vB-CcM phages at different (MOIs) against multidrug resistance Campylobacter strains was evaluated. The bacterial growth was slightly delayed by both phages, and the highest efficiency of both phages was observed when MOI = 1 was applied.
Disruption of a heliospheric current sheet fold

We present results from a new magnetohydrodynamic model of the inner heliosphere. We focus in this study on Carrington rotation 1892 which occurred during solar minimum, and simulate the solar wind and heliospheric magnetic field from 0.1 to 2 AU. We demonstrate the development of small scale (∼1° × 1° × 1 solar radius) structure, such as folds and ripples, on the surface of the heliospheric current sheet. In particular, we analyze the evolution of a current sheet fold forming by ∼1 AU, significantly narrowing by ∼1.5 AU (∼1° in width), and quickly disrupting afterwards. The disruption constitutes a process whereby the lower part of the current sheet fold separates from the main surface and, on a heliocentric spherical surface, appears as an island of outward polarity in the sea of the field of inward polarity. We show that this process is associated with non‐radial motion of plasma and magnetic field induced inside a stream interaction region. In addition, we discuss evidence of magnetic reconnection in our simulation that involves flux tubes in the vicinity of the heliospheric current sheet. The simulations presented here provide a useful global 3‐dimensional context for interpreting multiple current sheet crossings commonly observed by spacecraft as well as observations of magnetic reconnection in the solar wind.
Volume Under the Surface: A New Accuracy Evaluation Measure for Time-Series Anomaly Detection

Anomaly detection (AD) is a fundamental task for time-series analytics with important implications for the downstream performance of many applications. In contrast to other domains where AD mainly focuses on point-based anomalies (i.e., outliers in standalone observations), AD for time series is also concerned with range-based anomalies (i.e., outliers spanning multiple observations). Nevertheless, it is common to use traditional point-based information retrieval measures, such as Precision, Recall, and F-score, to assess the quality of methods by thresholding the anomaly score to mark each point as an anomaly or not. However, mapping discrete labels into continuous data introduces unavoidable shortcomings, complicating the evaluation of range-based anomalies. Notably, the choice of evaluation measure may significantly bias the experimental outcome. Despite over six decades of attention, there has never been a large-scale systematic quantitative and qualitative analysis of time-series AD evaluation measures. This paper extensively evaluates quality measures for time-series AD to assess their robustness under noise, misalignments, and different anomaly cardinality ratios. Our results indicate that measures producing quality values independently of a threshold (i.e., AUC-ROC and AUC-PR) are more suitable for time-series AD. Motivated by this observation, we first extend the AUC-based measures to account for range-based anomalies. Then, we introduce a new family of parameter-free and threshold-independent measures, VUS (Volume Under the Surface), to evaluate methods while varying parameters. Our findings demonstrate that our four measures are significantly more robust in assessing the quality of time-series AD methods.