Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards a Soil Remediation Strategy Using Biochar: Effects on Soil Chemical Properties and Bioavailability of Potentially Toxic Elements

Soil contamination with potentially toxic elements (PTEs) is considered one of the most severe environmental threats, while among remediation strategies, research on the application of soil amendments has received important consideration. This review highlights the effects of biochar application on soil properties and the bioavailability of potentially toxic elements describing research areas of intense current and emerging activity. Using a visual scientometric analysis, our study shows that between 2019 and 2020, research sub-fields like earthworm activities and responses, greenhouse gass emissions, and low molecular weight organic acids have gained most of the attention when biochar was investigated for soil remediation purposes. Moreover, biomasses like rice straw, sewage sludge, and sawdust were found to be the most commonly used feedstocks for biochar production. The effect of biochar on soil chemistry and different mechanisms responsible for PTEs’ immobilization with biochar, are also briefly reported. Special attention is also given to specific PTEs most commonly found at contaminated soils, including Cu, Zn, Ni, Cr, Pb, Cd, and As, and therefore are more extensively revised in this paper. This review also addresses some of the issues in developing innovative methodologies for engineered biochars, introduced alongside some suggestions which intend to form a more focused soil remediation strategy.
Clinical Impact of FDG-PET/CT Compared with CE-CT in Response Monitoring of Metastatic Breast Cancer

Simple Summary The method of treatment evaluation in patients with chronic breast cancer may affect clinical decision making and treatment protocols. In this study, we compared the two imaging modalities for the evaluation of treatment responses in 65 patients with spread breast cancer. We included 34 patients who underwent contrast-enhanced computed tomography (CE-CT) and 31 patients who underwent positron emission tomography/computed tomography (FDG-PET/CT). Then, we compared the response categories and clinical effects within the two modalities during a follow-up period of an average of 17.3 months. Our results showed that CE-CT modality reported more scans as stable disease, while FDG-PET/CT modality reported regressive metastatic disease more often. This means that FDG-PET/CT responds more precisely with respect to the changes in patients’ clinical condition, while CE-CT tends to report stable disease in most of the scans. Therefore, FDG-PET/CT may be a more suitable imaging modality than CE-CT for the evaluation of treatment in patients with metastatic breast cancer. Abstract We compared response categories and impacts on treatment decisions for metastatic breast cancer (MBC) patients that are response-monitored with contrast-enhanced computed-tomography (CE-CT) or fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT). A comparative diagnostic study was performed on MBC patients undergoing response monitoring by CE-CT (n = 34) or FDG-PET/CT (n = 31) at the Odense University Hospital (Denmark). The responses were assessed visually and allocated into categories of complete response (CR/CMR), partial response (PR/PMR), stable disease (SD/SMD), and progressive disease (PD/PMD). Response categories, clinical impact, and positive predictive values (PPV) were compared for follow-up scans. A total of 286 CE-CT and 189 FDG-PET/CT response monitoring scans were performed. Response categories were distributed into CR (3.8%), PR (8.4%), SD (70.6%), PD (15%), and others (2.1%) by CE-CT and into CMR (22.2%), PMR (23.8%), SMD (31.2%), PMD (18.5%), and others (4.4%) by FDG-PET/CT, revealing a significant difference between the groups (P < 0.001). PD and PMD caused changes of treatment in 79.1% and 60%, respectively (P = 0.083). PPV for CE-CT and FDG-PET/CT was 0.85 (95% CI: 0.72–0.97) and 0.70 (95% CI: 0.53–0.87), respectively (P = 0.17). FDG-PET/CT indicated regression of disease more frequently than CE-CT, while CE-CT indicated stable disease more often. FDG-PET/CT seems to be more sensitive than CE-CT for monitoring response in metastatic breast cancer.
Effect of Rehabilitation Nutrition on a Post-Acute Severe COVID-19 Patient: A Case Report

Coronavirus disease 2019 (COVID-19) may lead to post-acute physical function deterioration due to intensive-care-unit-acquired weakness-related sarcopenia and dyspnea. Limited reports have examined the effects of rehabilitation and nutritional therapy on patients with post-acute COVID-19. We present the case of a 67-year-old man, who was admitted for the treatment of post-acute severe COVID-19, who benefited from rehabilitation nutrition. When the patient’s condition stabilized, sarcopenia and malnutrition were observed, and rehabilitation nutrition was implemented. The physical therapist implemented a program focused mainly on resistance training and aerobic exercise, and the dietitian provided oral nutritional supplements and hospital food that met the patient’s energy and protein intake requirements. Comparing the initial evaluations with those at discharge, factors affecting nutritional status, such as body mass index and skeletal muscle mass index, and physical functions, such as grip strength and walking speed, and dyspnea, had improved. The patient was discharged and returned to work. This case suggests improvements in the nutritional status and physical functions of post-acute severe COVID-19 patients by interventions following rehabilitation nutrition.
Meta-Analysis and Machine Learning Models to Optimize the Efficiency of Self-Healing Capacity of Cementitious Material

Concrete and cement-based materials inherently possess an autogenous self-healing capacity. Despite the huge amount of literature on the topic, self-healing concepts still fail to consistently enter design strategies able to effectively quantify their benefits on structural performance. This study aims to develop quantitative relationships through statistical models and artificial neural network (ANN) by establishing a correlation between the mix proportions, exposure type and time, and width of the initial crack against suitably defined self-healing indices (SHI), quantifying the recovery of material performance. Furthermore, it is intended to pave the way towards consistent incorporation of self-healing concepts into durability-based design approaches for reinforced concrete structures, aimed at quantifying, with reliable confidence, the benefits in terms of slower degradation of the structural performance and extension of the service lifespan. It has been observed that the exposure type, crack width and presence of healing stimulators such as crystalline admixtures has the most significant effect on enhancing SHI and hence self-healing efficiency. However, other parameters, such as the amount of fibers and Supplementary Cementitious Materials have less impact on the autogenous self-healing. The study proposes, through suitably built design charts and ANN analysis, a straightforward input–output model to quickly predict and evaluate, and hence “design”, the self-healing efficiency of cement-based materials.
Effects of Resistance Exercise with or without Whey Protein Supplementation on Ocular Changes after a 21-Day Head-Down Bed Rest

Neuro-ophthalmological changes have been reported after prolonged exposure to microgravity; however, the pathophysiology remains unclear. The objectives of the present study were twofold: (1) to assess the neuro-ophthalmological impact of 21 days of head-down bed rest (HDBR) and (2) to determine the effects of resistance vibration exercise (RVE) alone or combined with nutritional supplementation (NeX). In this case, 12 healthy male subjects completed three interventions of a 21-day HDBR: a control condition without countermeasure (CON), a condition with resistance vibration exercise (RVE) comprising of squats, single leg heel and bilateral heel raises and a condition using also RVE associated with nutritional supplementation (NeX). Intraocular pressure (IOP) was assessed by applanation tonometry. Retinal nerve fiber layer thickness (RNFLT) was assessed with spectral-domain optical coherence tomography, before HDBR and between Day 2 and Day 4 after each session of HDBR. In CON condition, IOP was preserved; while in RVE and NeX conditions, IOP was increased. In CON condition, RNFLT was preserved after HDBR. RVE and NeX conditions did not have significant effects on RNFLT. This study showed that a 3-week HDBR did not induce significant ophthalmological changes. However, RVE induced an elevation in IOP after HDBR. Nutritional supplementation did not reduce or exacerbate the side effects of RVE.
r-process enhanced metal-poor stars

In this review we summarize the current state of some aspects of observational studies of low metallicity stars that have been enriched with products of rapid-neutron-capture (r-process) nucleosynthesis events. Attention will be drawn to the element domains where there is little star-tostar variation in relative abundances (such as the rare earths), and those with substantial variations (the lightest neutron-capture elements and the very heavy radioactive elements Th and U). We highlight some new work bearing on our understanding of the limits of abundance distributions that can be produced in the r-process. Finally, comments will be made on the metallicity at which significant contributions from the s-process can be seen in Galactic halo stars.
Different Roles of Telehealth and Telemedicine on Medical Tourism: An Empirical Study from Azerbaijan

With the rapid progress in mobile healthcare and Internet medicine, the impact of telehealth and telemedicine on the satisfaction of patients and their willingness to travel has become a focus of the academic research community. This study analyses the differences between telehealth and telemedicine and their role in medical tourism. We examine how the information quality and communication quality of telehealth and telemedicine influence patient satisfaction, and their effects on patients’ willingness to undertake medical travel and on their medical travel behaviours. We conducted an empirical study on the use of telehealth and telemedicine and on medical travel behaviour in Azerbaijan using a survey for data collection. A total of 500 results were collected and analysed using SmartPLS 3.0. Results show that (1) the communication quality and information quality of telehealth and telemedicine and their effects on satisfaction have significantly positive influences on willingness to undertake medical travel; (2) the psychological expectations of value and cost (perceived value and perceived cost) have a positive influence on medical travel; and (3) willingness to participate in medical travel positively influences medical travel behaviour. Moreover, results of this study have implications for research on, and the practice of, using telehealth and telemedicine as they relate to medical tourism. This research may help improve knowledge about telehealth and telemedicine and understand the differences between them in detail. This empirical research model may also be useful for researchers from other countries who wish to measure medical travel behaviour.
Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer

Prostate cancer (PCa) is the leading cause of cancer-associated mortality in men, and new biomarkers are still needed. The expression pattern and protein tissue localization of proteoglycans of the syndecan family (SDC 1–4) and syntenin-1 (SDCBP) were determined in normal and prostatic tumor tissue from two genetically engineered mouse models and human prostate tumors. Studies were validated using SDC 1–4 and SDCBP mRNA levels and patient survival data from The Cancer Genome Atlas and CamCAP databases. RNAseq showed increased expression of Sdc1 in Pb-Cre4/Ptenf/f mouse Pca and upregulation of Sdc3 expression and downregulation of Sdc2 and Sdc4 when compared to the normal prostatic tissue in Pb-Cre4/Trp53f/f-;Rb1f/f mouse tumors. These changes were confirmed by immunohistochemistry. In human PCa, SDC 1–4 and SDCBP immunostaining showed variable localization. Furthermore, Kaplan–Meier analysis showed that patients expressing SDC3 had shorter prostate-specific survival than those without SDC3 expression (log-rank test, p = 0.0047). Analysis of the MSKCC-derived expression showed that SDC1 and SDC3 overexpression is predictive of decreased biochemical recurrence-free survival (p = 0.0099 and p = 0.045, respectively), and SDC4 overexpression is predictive of increased biochemical recurrence-free survival (p = 0.035). SDC4 overexpression was associated with a better prognosis, while SDC1 and SDC3 were associated with more aggressive tumors and a worse prognosis.
Treatment Resistance: A Time-Based Approach for Early Identification in First Episode Psychosis

Although approximately 1/3 of individuals with schizophrenia are Treatment Resistant (TR), identifying these subjects prospectively remains challenging. The Treatment Response and Resistance in Psychosis working group defines <20% improvement as an indicator of TR, though its utility in First Episode Schizophrenia (FES) remains unknown. In a prospective cohort of FES (n = 129) followed up for 5 years, we evaluated two improvement thresholds for ‘probable TR’; <20% and <50% based on positive, negative, and total symptoms. We ascertained (1) the ecological validity (i.e., the ability to identify an expected subgroup of 1/3rd of patients); (2) the predictive validity (i.e., ability to predict poor global functioning) and (3) the clinical utility (association with clozapine use at the 5th year). Using the criteria of a total symptom reduction of <50% or negative symptom reduction of <20% resulted in ‘probable TR’ rates of 37% and 33%, respectively. Using <20% positive or total symptoms criteria resulted in very low rates, indicating minimal utility in FES. <50% total symptom criterion best predicted the global functioning over 5 years. Clozapine use was only predicted by positive symptom criterion. Prospective characterization of TRS is possible at 6 months after FES through a time-based approach using a 50% threshold for symptom change in treatment-adherent patients.
Antagonists of Growth Hormone-Releasing Hormone Inhibit the Growth of Pituitary Adenoma Cells by Hampering Oncogenic Pathways and Promoting Apoptotic Signaling

Simple Summary Many studies have demonstrated that the antagonists of growth hormone-releasing hormone (GHRH) exert inhibitory activities in a variety of experimental cancers; however, their potential antitumor role in pituitary adenomas (PAs) remains largely unknown. Here, we show that GHRH antagonists of Miami (MIA) class, MIA-602 and MIA-690, are able to reduce the growth and promote cell death in hormone-secreting PA cell lines, through the inhibition of mechanisms implicated in tumorigenesis and cancer progression. MIA-602 and MIA-690 also decreased the viability of tumor cells derived from human pituitary tumors. Overall, these findings suggest that GHRH antagonists may represent new therapeutic tools for the treatment of PAs, both alone or in combination with standard pharmacological treatments. Abstract Pituitary adenomas (PAs) are intracranial tumors, often associated with excessive hormonal secretion and severe comorbidities. Some patients are resistant to medical therapies; therefore, novel treatment options are needed. Antagonists of growth hormone-releasing hormone (GHRH) exert potent anticancer effects, and early GHRH antagonists were found to inhibit GHRH-induced secretion of pituitary GH in vitro and in vivo. However, the antitumor role of GHRH antagonists in PAs is largely unknown. Here, we show that the GHRH antagonists of MIAMI class, MIA-602 and MIA-690, inhibited cell viability and growth and promoted apoptosis in GH/prolactin-secreting GH3 PA cells transfected with human GHRH receptor (GH3-GHRHR), and in adrenocorticotropic hormone ACTH-secreting AtT20 PA cells. GHRH antagonists also reduced the expression of proteins involved in tumorigenesis and cancer progression, upregulated proapoptotic molecules, and lowered GHRH receptor levels. The combination of MIA-690 with temozolomide synergistically blunted the viability of GH3-GHRHR and AtT20 cells. Moreover, MIA-690 reduced both basal and GHRH-induced secretion of GH and intracellular cAMP levels. Finally, GHRH antagonists inhibited cell viability in human primary GH- and ACTH-PA cell cultures. Overall, our results suggest that GHRH antagonists, either alone or in combination with pharmacological treatments, may be considered for further development as therapy for PAs.
Unravelling the Role of Synthesis Conditions on the Structure of Zinc Oxide-Reduced Graphene Oxide Nanofillers

The diversity of zinc oxide (ZnO) particles and derived composites applications is highly dependent on their structure, size, morphology, defect amounts, and/or presence of dopant molecules. In this work, ZnO nanostructures are grown in situ on graphene oxide (GO) sheets by an easily implementable solvothermal method with simultaneous reduction of GO. The effect of two zinc precursors (zinc acetate (ZA) and zinc acetate dihydrate (ZAD)), NaOH concentration (0.5, 1 or 2 M), and concentration (1 and 12.5 mg/mL) and pH (pH = 1, 4, 8, and 12) of GO suspension were evaluated. While the ZnO particle morphology shows to be precursor dependent, the average particle size length decreases with lower NaOH concentration, as well as with the addition of a higher basicity and concentration of GO suspension. A lowered band gap and a higher specific surface area are obtained from the ZnO composites with higher amounts of GO suspension. Otherwise, the low concentration and the higher pH of GO suspension induce more lattice defects on the ZnO crystal structure. The role of the different condition parameters on the ZnO nanostructures and their interaction with graphene sheets was observed to tune the ZnO–rGO nanofiller properties for photocatalytic and antimicrobial activities.
Super-Dispersed Fe–N Sites Embedded into Porous Graphitic Carbon for ORR: Size, Composition and Activity Control

Searching for high-efficient, good long-term stability, and low-cost electrocatalysts toward oxygen reduction reaction (ORR) is highly desirable for the development of sustainable energy conversion devices. Iron–nitrogen doped carbon (Fe–N/C) catalysts have been recognized as the most promising candidates for traditional Pt-based catalysts that benefit from their high activity, excellent anti-poisoning ability, and inexpensiveness. Here, a super-dispersed and high-performance Fe–N/C catalyst was derived from chemically Fe-doped zeolitic imidazolate frameworks (ZIFs) by directly bonding Fe ions to imidazolate ligands within 3D frameworks. It produced a series of catalysts, whose sizes could be tuned in the range from 62 to over 473 nm in diameter. After rationally regulating the component and heating treatment, the best ORR activity was measured for the catalyst with a size of 105 nm, which was obtained when the Fe3+/Zn2+ molar ratio was 0.05 and carbonization temperature was 900 °C. It exhibited a high onset potential (Eonset = 0.99 V) and half-wave potential (E1/2 = 0.885 V) compared with a commercial 20% Pt/C catalyst (Eonset = 0.10 V, E1/2 = 0.861 V) as well as much better durability and methanol resistance in an alkaline electrolyte.
Passivity and Finite-Time Passivity for Multi-Weighted Fractional-Order Complex Networks With Fixed and Adaptive Couplings

This article presents several new <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-passivity and <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-finite-time passivity (<inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-FTP) concepts for the fractional-order systems with different input and output dimensions, which are distinct from the concepts for integer-order systems and extend the existing passivity and FTP definitions to some extent. On one hand, we not only develop some sufficient conditions for ensuring the <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-passivity of the multi-weighted fractional-order complex dynamical networks (MWFOCDNs) with fixed and adaptive couplings, but also discuss the synchronization for the MWFOCDNs based on the <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-output-strict passivity (<inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-OSP). On the other hand, the <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-FTP for the MWFOCDNs with fixed and adaptive couplings are also studied on the basis of the designed state feedback controller, and the relationship between finite-time synchronization (FTS) and <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula>-FTP for the MWFOCDNs is also illustrated. Finally, two numerical examples with simulation results are used to demonstrate the validity of the obtained criteria.
Long-term efficacy of ultrasound-guided laser ablation for papillary thyroid microcarcinoma: Results of a 10-year retrospective study.

BACKGROUND The aim of this study was to evaluate the 10-year efficacy and safety of laser ablation (LA) for the treatment of solitary papillary thyroid microcarcinoma (PTMC). METHODS LA was performed on patients with low-risk PTMC (diagnosed using fine-needle aspiration cytology) who refused or were ineligible for surgery between 2008 and 2011. Ultrasonography was performed to evaluate the ablated volumes and potential recurrences on the day after the procedure, as well as at 1 week, 1, 3, and 6 months, and every 6 months thereafter for 10 years. Computed tomography (CT) with contrast enhancement and positron emission tomography/CT was performed to evaluate local recurrences and distant metastases. RESULTS A total of 90 PTMCs in 90 patients were treated in a single session of LA, and the procedure was well tolerated by the patients. The mean follow-up duration was 112 months. By 3-10 months after the LA, all the ablation areas had disappeared or presented as scars. The disappearance rate was 100% after 12 months. Thyroid hormone and autoantibody levels did not change significantly after the treatment. Three patients experienced transient voice changes, but each recovered within 1 month. Additional PTMC foci were subsequently detected in previously untreated areas in five patients (5.5%) 17-56 months after the treatment. A metastatic lymph node was detected in one patient (1.1%) within 2 months of the treatment; however, it was determined to be an undetected cancer metastasis, rather than a recurrence. All the patients with recurrence underwent surgery, and there were no instances of recurrence after > 5 years. CONCLUSIONS LA is effective and safe for the treatment of low-risk PTMCs. A thorough examination of multifocality and lymph node metastasis status is required before considering LA treatment.