Miracle-dz/UniFAR-FTUs huggingface dataset:
Racial, Ethnic, and Nativity Disparities in Physical Activity and Sedentary Time among Cancer Prevention Study-3 Participants

ABSTRACT Purpose Understanding racial/ethnic and nativity disparities in physical activity (PA) is important, as certain subgroups bear a disproportionate burden of physical inactivity–related diseases. This descriptive study compared mean leisure-time moderate-to-vigorous intensity physical activity (LTMVPA) by race/ethnicity and nativity. Methods The Cancer Prevention Study-3 (78.1% women; age, 47.9 ± 9.7 yr) includes 4722 (1.9%) Asian/Pacific Islander; 1232 (0.5%) Black/Indigenous (non-White) Latino; 16,041 (6.5%) White Latino; 9295 (3.8%) non-Latino Black; 2623 (1.1%) Indigenous American; and 210,504 (85.7%) non-Latino White participants across the United States and Puerto Rico. Participants completed validated LTMVPA and 24-h time use surveys at enrollment (2006–2013). Differences in LTMVPA across race/ethnicity and nativity were examined by ANCOVA with paired Tukey tests adjusting for age and sex. The proportion of time spent sitting, sleeping, and on PA by race/ethnicity was also compared. Results There were significant differences in LTMVPA by race/ethnicity (race main effect, P < 0.001; nativity, P = 0.072; interaction, P < 0.001). Pairwise comparisons showed that White participants born abroad were the most active (23.8 MET-h·wk−1) and non-White Latino participants born abroad were the least active (17.9 MET-h·wk−1). Among Latinos, participants born in Puerto Rico were 6.6–7.3 MET-h·wk−1 less active than participants born in Mexico, the United States/Canada, or other countries. There were variations in time use by race/ethnicity, with the largest difference in time spent sitting while watching TV. Black participants spent 14.8% of the day (~3.5 h) sitting watching TV, which was 78 min longer than Asian/Pacific Islander participants. Conclusions This study suggests that there are differences in LTMVPA accumulation by race, ethnicity, and nativity. Results can be used to identify demographic groups that may benefit from culturally tailored PA interventions.
Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

The B.1. 1.529 Omicron variant jeopardizes vaccines designed with early pandemic spike antigens. Here, we evaluated in mice the protective activity of the Moderna mRNA-1273 vaccine against B.1. 1.529 before or after boosting with preclinical mRNA-1273 or mRNA-1273.529, an Omicron-matched vaccine. Whereas two doses of mRNA-1273 vaccine induced high levels of serum neutralizing antibodies against historical WA1/2020 strains, levels were lower against B.1. 1.529 and associated with infection and inflammation in the lung. A primary vaccination series with mRNA-1273.529 potently neutralized B.1. 1.529 but showed limited inhibition of historical or other SARS-CoV-2 variants. However, boosting with mRNA-1273 or mRNA-1273.529 vaccines increased serum neutralizing titers and protection against B.1. 1.529 infection. Nonetheless, the levels of inhibitory antibodies were higher, and viral burden and cytokines in the lung were slightly lower in mice given the Omicron-matched mRNA booster. Thus, in mice, boosting with mRNA-1273 or mRNA-1273.529 enhances protection against B.1. 1.529 infection with limited differences in efficacy measured.
Review of the Methods to Optimize Power Flow in Electric Vehicle Powertrains for Efficiency and Driving Performance

Electric vehicles (EV) are quickly gaining a foothold in global markets due to their zero tailpipe emissions and increasing practicality in terms of battery technologies. However, even though EV powertrains emit zero emissions during driving, their efficiency has not been fully optimized, particularly due the commonly used single-speed transmission. Hence, this paper provides an extensive review on the latest works carried out to optimize the power flow in EV powertrains using multispeed discrete transmission, continuously variable transmission and multi-motor configurations. The relevant literatures were shortlisted using a keyword search related to EV powertrain in the ScienceDirect and Scopus databases. The review focused on the related literatures published from 2018 onwards. The publications were reviewed in terms of the methodologies applied to optimize the powertrain for efficiency and driving performance. Next, the significant findings from these literatures were discussed and compared. Finally, based on the review, several future key research areas in EV powertrain efficiency and performance are highlighted.
Logistics Management and Marketing Performance of Small and Medium-Sized Manufacturing Firms

This study explored logistics management and marketing performance of small and medium-sized manufacturing firms. It aimed to assess the influence of order processing, transportation, inventory and warehouse management on the marketing performance of small and medium-sized manufacturing firms. As a cross-sectional study, primary data were obtained from 216 operators and personnel of small and medium-sized manufacturing firms using a structured questionnaire. The research instrument was validated through face and content validity method, while reliability was confirmed through Cronbach’s alpha method. The hypotheses developed for the study were tested using multiple linear regression. Consequently, the study revealed that order processing management, transportation management, inventory management and warehouse management had significant positive influences on the marketing performance of small and medium-sized manufacturing firms. Therefore, the study concluded that logistics management has a significant positive influence on marketing performance in the context of small and medium-sized manufacturing firms. Practical implications and a future research agenda were presented in light of the limitations of this study.
Level of knowledge toward essential newborn care practices among postnatal mothers in governmental hospitals of Harar Town, Eastern Ethiopia

Objectives: Essential newborn care is a set of comprehensive recommendations designed by the World Health Organization to improve the newborn’s health through intervention before conception, during pregnancy, soon after birth, and the postnatal period. Globally 4 million newborns die every year before they reach the age of 1 month. Therefore, this study assessed the level of knowledge and associated factors toward essential newborn care practices among postnatal mothers attending postnatal service in governmental hospital of Harar town, Eastern Ethiopia, 2020 Methods: Facility-based cross-sectional study was conducted in Harar Town, Jugul, and HiwotFana Specialized University Hospital. Voluntary postnatal mothers who are randomly selected were participated in the study. A total number of 266 women were included in the study. Data were collected through face-to-face interviews. The training was given for data collectors, and data evaluation was done on daily basis. Cleaned data were entered to SPSS version 20, and multiple logistic regression analysis was used for better prediction of determinants and to reduce bias due to confounders. Those variables with a p value less than 0.25 were entered into multiple logistic regression analyses. Associations with p value less than 0.05 were declared as statistically significant. Text, figures, and tables presented the result. Result: The overall prevalence of good knowledge was 57.2%. Educational status, average monthly income, antenatal care visit, and parity had significantly associated with outcome variables. Conclusion: More than half of mothers had inadequate newborn care knowledge. In addition, educational status, average family monthly income, frequency of antenatal care visit, and parity were independently associated with knowledge on essential newborn care. Therefore, more significant improvement in essential newborn care practices could be attained through policy implications and recommendations. Therefore, we recommend that stakeholders of the health sector have a close follow-up on maternal and newborn care services and maintain a strategy that will incorporate maternal education service on essential newborn care practice.
Latest Triassic–Early Jurassic Stikine–Yukon-Tanana terrane collision and the onset of accretion in the Canadian Cordillera: Insights from Hazelton Group detrital zircon provenance and arc–back-arc configuration

The Hazelton Group is a Rhaetian–Bajocian (uppermost Triassic–Middle Jurassic) volcano-sedimentary sequence that represents both the last pre-accretionary arc volcanic cycle of Stikinia and its early synaccretionary aftermath. Hazelton magmatism of central Stikinia succeeded the Late Triassic (mainly Carnian–Norian) Stuhini arc, which ceased activity as a result of end-on collision with the pericratonic Yukon-Tanana terrane. The Hazelton volcanic belt lies to the south along strike with the coeval Whitehorse trough, the synorogenic clastic basin that developed on top of the Stikinia–Yukon-Tanana collision zone. Whereas the sources of voluminous clastic sediments in the Whitehorse trough were its rapidly exhuming shoulders, the thin clastic intervals in the Hazelton Group in northwestern British Columbia were derived from local to subregional block uplifts that supplied mainly ca. 230–215 Ma zircons eroded from the plutonic roots of the Stuhini arc. Lesser components include late Paleozoic (ca. 350–330 Ma) zircons from Stikinia’s basement and penecontemporaneous (ca. 205–172 Ma) zircons from Hazelton volcanic/subvolcanic sources. Reexamination of the four main volcanic fields that make up the lower Hazelton Group suggests that the main Hazelton volcanic belt formed a southward-convex magmatic arc from eastern Stikinia across the Skeena arch, including the Toodoggone and Telkwa belts, with the Spatsizi and Stewart-Iskut regions of northwestern British Columbia in its back-arc. The Whitehorse trough and Hazelton belt represent a collision zone to active arc pair. Southward advance of the arc and counterclockwise rotation of the Stikinia microplate contributed to closure against the Quesnellia arc and assembly of the inner Canadian Cordilleran terrane collage.
The prognostic value of reduced global longitudinal strain (GLS) on cardiac outcomes in patients on peritoneal dialysis: a prospective study

Type of funding sources: None. This study aims to evaluate the capacity of left ventricular global longitudinal strain (GLS) in end stage renal failure patients on peritoneal dialysis (PD) to predict cardiovascular mortality and major adverse cardiac events (MACE). GLS has been an established parameter in detecting subclinical left ventricular systolic dysfunction in the setting of preserved ejection fraction (EF > = 50%). We hypothesized that reductions of GLS (i.e. less negative value) are associated with adverse cardiovascular outcome. We prospectively recruited a total of 60 PD patients from a single dialysis center in a tertiary hospital. GLS was determined by two-dimensional speckle-tracking echocardiography, under Philips QLab system. A less negative value reflects underlying subclinical LV dysfunction. The primary outcome was 4-point MACE, which was a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke and hospitalization for heart failure. Surrogate markers of inflammation (C-reactive protein [CRP], tumor necrosis factor [TNF]-alpha), nutrition (serum albumin), arterial stiffness (pulse wave velocity [PWV]), and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) were also measured. 16 (26.7%) and 34 (56.7%) PD patients had reduced GLS (≥ -18.3%) and left ventricular hypertrophy (LVH) respectively. In 12-month follow up, 4-point MACE occurred in 13.6% and 59.8% of normal and compromised GLS patients respectively (log-rank, P = 0.004), as illustrated by Kaplan-Meier curves (Fig 1). Patients with reduced GLS had higher proportion of uncontrolled blood pressure and higher prevalence of coronary artery disease. Their EF were significantly lower (53.6 ± 7.4% vs. 61.3 ± 4.1%, P= 0.001) compared with patients with normal GLS. In addition, GLS correlated with EF (r = -0.57, P <0.0001) and PWV (r= 0.33, P = 0.01). There was a trend towards an association between GLS and ln(CRP) (r= 0.25, P = 0.057), and ln(NT-proBNP) (r = 0.22, P= 0.09), respectively. Subclinical LV systolic dysfunction was present in one-fourth of peritoneal dialysis patients despite having preserved EF. Reduced GLS (less negative than 18.3%, illustrated in Fig 2) is a strong predictor of poor cardiovascular prognosis among PD population. Abstract Figure 1 Abstract Figure 2
Comparative characteristics of the physical and technical preparedness of the women's national team of Ukraine and Lithuania basketball (hearing impaired) before and after training to Deaflympic Games

Purpose: to compare the physical and technical readiness women basketball teams of Ukraine and Lithuania. Material : participated in the study of female athletes team of Ukraine and Lithuania (n = 24). Athletes age - 25-30 years. Teacher testing was conducted physical and technical readiness. Ukrainian team trained by the author's method with the use of innovative technologies. Included the use of technology in the training process of copyright video tutorials with animated illustrations and LED linear luminaire. Results : the results indicated significant improvement of athletes Ukrainian team in the tests: a standing jump, cross 2000 meters, throwing a medicine ball with a running start, lifting the trunk in 30 seconds from a prone position, speed equipment, three points shots, special endurance. The proposed new management training process helped increase mobility, intensity and complexity of team training in Ukraine. Conclusions : It is recommended to use a program of technical and tactical training with the use of innovative technologies in the training process basketball players are hearing impaired.
Could combination chemotherapy be more effective than monotherapy in the treatment of visceral leishmaniasis? A systematic review of preclinical evidence

Abstract Abstract From a systematic review framework, we assessed the preclinical evidence on the effectiveness of drug combinations for visceral leishmaniasis (VL) treatment. Research protocol was based on the PRISMA guideline. Research records were identified from Medline, Scopus and Web of Science. Animal models, infection and treatment protocols, parasitological and immunological outcomes were analysed. The SYRCLE's (SYstematic Review Center for Laboratory Animal Experimentation) toll was used to evaluate the risk of bias in all studies reviewed. Fourteen papers using mice, hamster and dogs were identified. Leishmania donovani was frequently used to induce VL, which was treated with 23 drugs in 40 different combinations. Most combinations allowed to reduce the effective dose, cost and time of treatment, in addition to improving the parasitological control of Leishmania spp. The benefits achieved from drug combinations were associated with an increased drug's half-life, direct parasitic toxicity and improved immune defences in infected hosts. Selection, performance and detection bias were the main limitations identified. Current evidence indicates that combination chemotherapy, especially those based on classical drugs (miltefosine, amphotericin B antimony-based compounds) and new drugs (CAL-101, PAM3Cys, tufisin and DB766), develops additive or synergistic interactions, which trigger trypanocidal and immunomodulatory effects associated with reduced parasite load, organ damage and better cure rates in VL.
Left atrial reservoir strain may be a load independent index of diastolic dysfunction in liver cirrhosis patients

Type of funding sources: None. Cirrhotic cardiomyopathy is characterized by high cardiac output, reduced peripheral resistance and diastolic dysfunction. Specifically, diastolic dysfunction has been correlated with the prognosis in liver cirrhotis patients independently of the disease severity. Left atrial reservoir strain (LASr) is a novel index which is inversely correlated with left ventricular end-diastolic pressure, but has not been adequately studied in cirrhotic patients. To investigate the correlations between LASr and diastolic function or disease severity in cirrhotic patients. Echocardiographic analysis of 51 consecutive cirrhotic patients was performed and images were analyzed off-line. LASr was calculated semi-automatically using dedicated software and was feasible in 49 patients. Clinical and biochemical examination was used to assess severity of liver disease by calculating MELD-Na score. Mean age was 58.0± 8.6 years, 37 (75.5%) were males, mean MELD-Na score was 15.6 ±7.5 and mean LASr was 39.7 ±12.5. LASr correlated with age (r=-0.415, p = 0.003), LAVI (r=-0.329, p = 0.022), e’ (r = 0.476, p = 0.001), E/e (r=-0.401, p = 0.004) and GLS (r=-0.388, p = 0.006), but not with ejection fraction, stroke volume or MELD-Na score. MELD-Na score correlated with ejection fraction (r = 0.316, p = 0.029), stroke volume (r = 0.549, p < 0.001), left atrial volume index (r = 0.575, p < 0.001), GLS (r = 0.521, p < 0.001), right atrial end systolic area (r = 0.368, p = 0.011) and right ventricular diameter (r = 0.541, p < 0.001) reflecting high cardiac output state in patients with advanced cirrhosis. LASr was significantly lower in patients with E/e’ >14 (22.5 ± 13.6) when compared to patients with E/e’ 8-14 (37.3± 10.6, p = 0.039) and E/e’<8 (44.7± 12.0, p = 0.003). The two latter groups also differed significantly (p = 0.034). LASr correlation with E/e’ was the only statistically significant correlation in a multiple regression model including left ventricular end diastolic volume, ejection fraction and left atrial volume (B=-1.371, P = 0.023). Correlation of LASr with MELD-Na score remained non-significant. LASr correlates inversely with E/e’ ratio in liver cirrhotic patients, but does not correlate with load dependent echocardiographic parameters and disease severity. Hence in this special population, LASr may be an earlier and more specific index of diastolic dysfunction than traditional echocardiographic indices. Further studies are needed to examine the prognostic significance of LASr in cirrhotic patients.
Eyelid carcinomas: Tumor aggressiveness tendencies for smokers compared to non-smokers

During the past few years, several studies have demonstrated that head and neck carcinomas present more aggressive forms for smokers, relative to non-smokers. Our aim was to investigate the tumor aggressiveness for patients with eyelid carcinomas, in relation to tobacco consumption, as well as other demographic and clinical data. For 98 patients with eyelid carcinomas, we studied the relationship between the duration of their symptoms and their tumor stage at first diagnosis, trying to determine potential correlations with smoking status and several other clinical parameters. Our data revealed that, for the same duration of symptoms, tobacco consumers tended to have higher tumor stages, which did not correlate with other variables. For early diagnosed tumors, within the first year of symptoms, smokers presented 6.044 times higher odds to exhibit more advanced tumor stages, compared to non-smokers, and this value decreased to 4.501, up to 5 years of the presence of symptoms (P<0.05). We also noted that, for smokers, an increased age was associated with increased tumor stages, which was opposed to non-smokers, regardless of their symptom duration [average odds ratio (OR) 1.122, P<0.05]. Tumor aggressiveness was therefore associated with tobacco consumption, leading to an increased risk of developing more aggressive forms of eyelid carcinomas for smokers, compared to non-smokers.
Prevalence of the elevated urea and creatinine level among hypertensives: Perspective to raise the awareness about disease complications

An increasing prevalence of hypertension and mortality rate from hypertension complications especially the end stage kidney disease; urge the establishment of routine test for early detection of kidney disease. The aim of this study is to assess the blood urea and creatinine levels in routine visit of hypertensive individuals. Two hundred hypertension patients were enrolled in this study, the demographic and lifestyle data were collected by pre-designed questionnaire. Urea and creatinine were measured for 151 and 159 patient, respectively, using spectrophotometry kits method. Of the studied hypertensive patients, about two third are females (64.5%), 92% aged more than 40 years. 32.5% had diabetes, and 5.5% had kidney disease. No significant gender difference with regard to the development of complications such as diabetes, stroke, kidney disease and hyperlipidemia (P = 0.7-1.0). In less than ten years duration of hypertension; 32%, 11%, 5% and 49% of the patients develop diabetes, stroke, kidney disease and hyperlipidemia, respectively, which suggest an inadequate disease control. Of the behavioral risk factors salt; intake is significantly higher in males than in females (P = 0.022). 38.4% and 35.2% of the analyzed samples had an elevated urea and creatinine level, respectively. Twenty four of samples (=15%) had both abnormal urea and creatinine. Within less than five years duration of hypertension; 25% and 23% of the patients had abnormal urea and creatinine level, respectively. Insignificant association of neither the abnormal level of urea nor the creatinine with hypertension complications was reported (P >- 0.09), however 36% and 35% of the hypertensive who were not previously diagnosed with kidney disease had an abnormal/elevated urea/creatinine level, respectively. More than thirty five percent of the hypertensives had urea or creatinine measurements above normal levels. Such abnormal level was reported in less than five years duration of hypertension and were also observed in 36% and 35% of the hypertensive who were not previously diagnosed with kidney disease, which indicates an uncontrolled hypertension, lack of awareness of disease complications, thereby reflects the importance of the routine measurement of urea and creatinine.
Monitoring Space Weather: Using Automated, Accurate Neural Network Based Whistler Segmentation for Whistler Inversion

It is challenging, yet important, to measure the—ever‐changing—cold electron density in the plasmasphere. The cold electron density inside and outside of the plasmapause is a key parameter for radiation belt dynamics. One indirect measurement is through finding the velocity dispersion relation exhibited by lightning induced whistlers. The main difficulty of the method comes from low signal‐to‐noise ratios for most of the ground‐based whistler components. To provide accurate electron density and L $L$ ‐shell measurements, whistler components need to be detectable in the noisy background, and their characteristics need to be reliably determined. For this reason, precise segmentation is needed on a spectrogram image. Here, we present a fully automated way to perform such an image segmentation by leveraging the power of convolutional neural networks, a state‐of‐the‐art method for computer vision tasks. Testing the proposed method against a manually, and semi‐manually segmented whistler data set achieved < $< $ 10% relative electron density prediction error for 80% of the segmented whistler traces, while for the L $L$ shell, the relative error is < $< $ 5% for 90% of the cases. By segmenting more than 1 million additional real whistler traces from Rothera station Antarctica, logged over 9 years, seasonal changes in the average electron density were found. The variations match previously published findings, and confirm the capabilities of the image segmentation technique.