Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Lymphangio vascular (V) and perineural (N) invasion on survival of patients with resected esophageal squamous cell carcinoma (ESCC): a single-center retrospective study

Background Lymphangio vascular invasion (LVI) and perineural invasion (PNI) are associated with survival following resection for gastrointestinal cancer. But the relationship between LVI/PNI and survival of esophageal squamous cell carcinoma (ESCC) is still unclear. We aim to demonstrate the prognostic significance of LVI/PNI in ESCC. Methods A total of 195 ESCC patients underwent curative surgery from 2012 to 2018 was collected in the 2nd Affiliated Hospital of Fujian Medical University. All the patients were divided into four groups based on the status of the neurovascular invasion: (1) neither LVI nor PNI (V0N0); (2) LVI alone (V1N0); (3) PNI alone (V0N1); (4) combined LVI and PNI (V1N1). First, the analysis included the Kaplan-Meier survival estimates with the Log rank test were performed to determine median overall survival (OS) in different groups divided according to the clinical factor, respectively. And the association between OS with multi clinical factors was examined using Cox regression analysis. Next, the risk factors for recurrence in patients with V1N1 were analyzed with univariate and multivariate logistic regression analyses, respectively. Results The cases in V0N0, V1N0, V0N1, and V1N1 groups were 91 (46.7%), 62 (31.8%), 9 (4.6%) and 33 (16.9%), respectively. The OS in the four groups was different (P < 0.001). The 1-, 3- and 5-year OS in V0N0 group was higher than that in V1N1 group, respectively (1-year OS: 93.4% vs 75.8%, 3-year OS: 53.8 % vs 24.2%, 5-year OS: 48.1% vs 10.5%). The OS in stage I-II for patients with V1N1 was significantly lower than that in the other groups (V0N0, V1N0, V0N1) (P < 0.001). The postoperative adjuvant chemotherapy was a significant impact factor of OS for ESCC patients with V1N1 (P = 0.004). Lymphatic invasion and LVI were significantly prognosis factors associated (P = 0.036, P = 0.030, respectively). The ulcerative type is a risk factor for V1N1 occurance (P = 0.040). Conclusions The LVI and PNI are important prognosis factors for ESCC patients. ESCC patients with simultaneous lymphangio vascular and perineural invasion (V1N1) showed worse OS than patients with either lymphangio vascular or perineural invasion alone (V1N0 or V0N1) or none (V0N0). In addition, adjuvant chemotherapy may prolong the OS for ESCC patients with V1N1.
Asymmetric Temperature Load Method for Simulation Study of Wing Leading Edge in Flight Deicing with MFC

Leading edge icing jeopardizes the aerodynamic performance of wing and the fly safety of airplane. Macro fiber composite(MFC) piezoelectric actuator possess favorable flexibility and large force output ability, which makes MFC quite suitable for the excitation of large curvature thin-walled structures such as wing leading edge. In this study, MFC is adopted for leading edge in flight deicing application. Key challenges of leading edge in flight deicing with MFC were investigated by finite element methodology and simulation approach, which include fundamental analysis of vibration deicing method, leading edge deicing excitation mode and MFC placement scheme determination. Base on thermal-elastic analogy modeling theory, asymmetric temperature load modeling method is proposed for the special actuation effect simulation of twist type MFC for deicing. Simulation results demonstrate the third natural vibration mode can be utilized for leading edge deicing with lowest energy consumption and twist type MFC has great potential for leading edge in flight deicing application.
Self-persuading norms: Adding a self-persuasion technique strengthens the influence of descriptive social norms

ABSTRACT Social norms have been implemented to change a variety of behaviors. Yet, these studies show noticeable dispersion of effects. We suggest that such dispersion is partially due to people perceiving reasons for following a certain norm to be more or less appealing. In testing this proposition, we couple descriptive norms with a self-persuading technique (i.e. the self-persuading norm). We propose that the self-persuading norm operate in two steps: 1) self-persuasion leads to value-matched information, 2) value-matched information is more self-relevant, making the norm more influential. Across three experiments, we consistently found that self-persuading norms are more influential than simple descriptive norms and a control condition. The practical applications are straightforward: adding self-persuasive content seems to strengthen the descriptive norm.
Anti-prolactin Agent with Gonadotropin-releasing Hormone Synergistically Improve Egg Production in Indigenous Chicken via Regulating Broody Behavior

Despite the indigenous chicken's many natural advantages, broodiness continues to be a substantial barrier to minimizing egg production and economic losses. Prolactin is the primary regulator of broodiness. As a result, the goal of our research was to see if lower prolactin levels can limit broodiness, resulting in increased egg production and increased economic value. Sixty indigenous chickens aged 18-20 weeks were divided into three groups of 20 hens each. One was left untreated, two were given GnRH (0.50 ml/bird @ S/C) with Anti-prolactin (Bromocriptine 640 g/bird/day @ orally), and three were given GnRH, Anti-prolactin, and cold therapy (1 time/day) for three months. The chickens were first given GnRH injections once a week for three weeks. It was given on the 13th day of egg production and continued for 10 days. After utilizing GnRH plus anti-prolactin medications for 13 days, the cold application was given every day at the same time. Hormone analysis, egg production, broody time, pause time was noted. Prolactin levels fell in all treatment groups. The number of egg production per clutch was significantly (p<0.05) increased in both treated groups, and the highest was recorded in GnRH plus anti-prolactin group (33eggs / clutch). Surprisingly, pause day and broody time significantly (p<0.05) decreased in the same Group B (7d, 4d respectively). Postmortem ovary analysis substantially supports the treatment group's finding against the control group. Overall, combining an anti-prolactin drug with GnRH enhances egg production by synergistically modulating broody behavior.
Analysis of buying decision levels based on brand image, price, and digital marketing

In carrying out business, there is one process that can be maximized in business development, which is the marketing aspect. Marketing is a total system of business activities designed to plan, price, promote, and distribute goods and services that satisfy the needs of both current customers and potential customers. This study is carried out on a business that pays attention to the marketing aspect for business development purposes, namely Elina Keramik Bandung. Customers who buy their products cannot be separated from their marketing strategies. The purpose of this study is to analyze the level of influence of the three marketing variables that can be found in Elina Keramik, namely brand image, price, and digital marketing on the level of customer buying decisions of Elina Keramik. The research method used in this study is a quantitative approach with a descriptive method. The sample that was used in this study is 125 respondents who are customers of Elina Keramik. The results obtained in this study are overall price, and digital marketing has a significant influence on buying decisions with a value of 70.6 percent. The variable price has a significant influence on buying decisions with a significant value of 0.43 <0.05. And the variable digital marketing has a significant influence on buying decisions with a significant value of 0.00 <0.05. While the variable brand image that was declared has no influence on buying decisions with a significant value of 0.06> 0.05.
Healthcare Professional Students’ Perspectives on Substance Use Disorders and Stigma: A Qualitative Study

Background: Access to and quality of care for Substance Use Disorders (SUDs) remain a major public health issue. Stigma associated with SUDs contributes to the gap between the number of patients who need treatment and the much smaller fraction that receive it. Healthcare professional students are future care providers; an opportunity exists to characterize their collective perspectives on patients with SUDs and how that informs the care they provide. Methods: Healthcare professional students participated in online, semi-structured focus group (FGs) between March and April 2021. The FGs were conducted until thematic saturation was achieved. All verbatim transcripts were analyzed applying Thematic Analysis using Dedoose® qualitative software. Inductive codes were grouped into categories based on similarities that facilitated the emergence of themes. Results: Thematic Analysis revealed one theme (1) Decreasing stigma among healthcare professionals by viewing substance use disorder as a disease; and two sub-themes: Subtheme 1a: Relating with the patients, “It could be me…”; Subtheme 1b: Interactions with patients, “We just don’t know exactly how to counsel these patients…” These themes describe how future healthcare professionals might perceive and approach patients with SUDs and highlight the importance of SUD training in the curriculum. Conclusion: Medical and pharmacy students are uniquely positioned to apply critical thinking from their didactic training to their real-world clinical experiences, and their collective perspectives inform gaps in training and opportunities to develop best practices for SUD care. An opportunity exists to leverage these findings in order to train future healthcare professionals to ensure access to and quality of SUD care.
Novel Nomogram Based on Inflammatory Markers for the Preoperative Prediction of Microvascular Invasion in Solitary Primary Hepatocellular Carcinoma

Purpose We aimed to develop and to validate a novel nomogram based on inflammatory markers to preoperatively predict microvascular invasion (MVI) in patients with solitary primary hepatocellular carcinoma (HCC). Patients and Methods Data from 658 patients with solitary primary HCC who underwent hepatectomy at the First Affiliated Hospital of Zhengzhou University from June 2018 to October 2021 were retrospectively analyzed. Patients were divided into training (n=441) and validation (n=217) cohorts according to surgical data. Independent risk factors for MVI were identified via univariate and multivariate logistic regression analyses in the training cohort. A novel nomogram was developed based on the independent risk factors identified. Its accuracy was evaluated using a calibration curve and concordance index (C-index). The predictive value was evaluated using the receiver operating characteristic (ROC) curve and decision curve analysis (DCA). Results Preoperative alpha-fetoprotein >969 µg/L (P<0.001), tumor size (P=0.002), neutrophil >1.8×109/L (P=0.002), gamma-glutamyl transpeptidase-to-platelet ratio (GPR) >0.32 (P=0.001), aspartate aminotransferase-to-platelet ratio (APR) >0.18 (P<0.001), gamma-glutamyl transpeptidase-to-albumin ratio (GAR) >2.30 (P=0.001), and gamma-glutamyl transpeptidase-to-lymphocyte ratio >29.58 (P<0.001) were identified as preoperative independent risk factors for MVI and were used to establish the nomogram. The C-index of the training and validation cohorts were 0.788 (95% confidence interval [CI]: 0.744–0.831) and 0.735 (95% CI: 0.668–0.802), respectively. The calibration curve analysis revealed that the standard curve fit well with the predicted curve. ROC curve analysis demonstrated high efficiency of the nomogram. DCA verified that the nomogram had notable clinical value. Conclusion Preoperative GPR >0.32, APR >0.18, and GAR >2.30 were independent risk factors for MVI in patients with solitary primary HCC, suggesting their utility as preoperative predictors of MVI. The novel nomogram developed and validated in this study may aid in determining optimal therapeutic approaches for patients with solitary HCC at risk for MVI.
Experimental and numerical study on wave drift forces on a semi-submersible platform in waves

In this paper, the research of mean and slowly varying wave drift forces on a moored semi-submersible platform in irregular moderate waves are carried out. Both experimental and numerical studies are included. Experimental tests with a semi-submersible platform model scaled at 1:70 in an ocean basin were performed with focus on wave drift forces at low frequencies. Both head sea and beam sea conditions were tested. The measured results are compared with numerical simulation using the diffraction analysis program based on three-dimensional potential theory in time domain. Both head sea and beam sea tests are considered. It is found that the experimental and numerical results agree well with each other in the smaller waves for both head and beam sea tests, but not so well in the higher wave for head sea test.
Leadership of cultural education in the current age: an exploratory investigation of culturally responsive capacity through the lens of transculturalism

ABSTRACT A key features of the globalised environment of the twenty-first century is that populations across a range of societies have become more diverse in culture, heritage and identity. In turn, this has led to further emphasis on the teaching of cultural understanding in schools, as exemplified by the Australian Curriculum and their equivalents in countries such as Singapore, India and New Zealand. However, educational research has tended to focus on cultural education for the students, with relatively little consideration given to the attributes required by both teachers and school leaders to frame and deliver cultural education that meets the multiple needs of twenty-first century cultural environments. This paper comprises an initial exploration of the connections between the educational concept of transcultural dispositions and culturally responsive leadership behaviours of school leaders as they work to deliver a form of cultural education that is relevant to the context of the twenty-first century.
The dynamic interaction of twin tunnels embedded in a homogeneous half-space

Vibration generated by underground railways can be a major source of disturbance to occupants of nearby buildings. The numerical prediction of ground-borne vibration is a complicated problem that has received extensive research attention in the past decades. However, simplifying assumptions are always required in state-of-the-art numerical models in order to reduce computational effort and resources. A common simplifying assumption is to neglect the presence of a neighbouring tunnel, despite the fact that many underground railway lines around the world consist of two tunnels. This paper investigates the dynamic interaction of two parallel tunnels embedded in a homogeneous half-space. Two different methods are used to tackle the problem. The first is a fully coupled approach, where two cavities are generated in the halfspace to which the tunnels are coupled. The second adopts a superposition approach, where two sub-models each consisting of a single tunnel are superposed to calculate the vibration response of the twin tunnels. In both modelling approaches, the tunnel wall is modelled using the thick-shell theory, while the boundary element method is used to simulate the half-space of the ground. The vibration response of the twin-tunnel system on the ground surface due to a harmonic point load at one tunnel invert is studied and compared to that of a single tunnel. The efficacy of the superposition method in modelling the dynamic interaction of the twin tunnels is assessed against the fully coupled approach at different points on the surface. The results reveal the significance of the interaction between the twin tunnels and also demonstrate the accuracy of the superposition method. The feasibility of the superposition method in modelling the dynamic interaction between tunnels and piled-foundations is also highlighted.
LIME AND GYPSUM MANAGEMENT REGIMES: SHORT TERM SOIL CHEMICAL PROPERTIES ALTERATIONS AND INITIAL MAIZE GROWTH

The objective of this work was to evaluate the short-term chemical changes in the soil and the initial maize growth as a function of different lime and gypsum management regimes. An experiment was set up in PVC tubes and the effects were evaluated at depths of 0-15cm and 15-30cm after 2 months. A second experiment was carried out in pots where maize was planted, and aerial and root system development were evaluated. The use of limestone and gypsum was tested separately, applied both at the same time and spaced one month apart, plus a control treatment. The application of limestone and gypsum at the same time and only limestone were the treatments that caused the most changes in the soil in the 0-15cm layer after 2 months. The combination of limestone and gypsum also increased root growth and therefore may be an interesting strategy for short-term soil correction.
Bold or shy? Examining the risk–taking behavior and neophobia of invasive and non–invasive house sparrows

Behavior provides a useful framework for understanding specialization, with animal personality aiding our understanding of the invasiveness of birds. Invasions imply dispersion into unknown areas and could require changes in behavior or spatial clustering based on personality. Reduced neophobia and increased exploring behavior could allow individuals to colonize new areas as they test and use non–familiar resources. Here, we hypothesized that house sparrow (Passer domesticus) individuals from invasive populations would exhibit bolder behavior than in non–invasive populations. We assessed risk taking and neophobia in male house sparrows in Barcelona (where it is considered native) and in Mexico City (where it has become widely invasive), captured in two different habitats, urban and non–urban. We assessed latency to enter an experimental cage and to explore it, and latency to feed and feeding time in the presence of a novel object. We found that sparrows from Mexico City, both from urban and non–urban areas, were quicker to enter the experimental cage than the sparrows from Barcelona. The time it took the birds to start exploring the cage gave a similar result. We found no differences between cities or habitats in the latency to feed and feeding time while exposed to a novel object. Our results partially support the view that the invader populations from Mexico City are bolder than those from Barcelona. Behavior is an important component of plasticity and its variability may have an important effect on adaptation to local situations. Future studies should disentangle the underlying mechanisms that explain the different personalities found in populations of different regions, contrasting populations of different densities, and taking different food availability scenarios into account.
The Effect of Device Type on Achievement: Evidence from a Quasi-Experimental Design

ABSTRACT As more states move to universal computer-based assessments, an emergent issue concerns the effect that device type might have on student results. Although, several research studies have explored device effects, most of these studies focused on the differences between tablets and desktops/laptops. In the current study, we distinguish between different types of devices to better examine the differences. Specifically, we used Indiana state assessment results from grades 3 and 8 and a propensity score weighting method to see if a student took the assessment on another device, would they have received the same score? Our findings suggest that there are significant differences by device type in both grades. In particular, iPad and Chromebook devices produced higher achievement when compared to Mac and PC devices. At the extreme, these differences amounted to close to a third of a standard deviation on the achievement scale.
Power transfer using portable surfaces in capacitively coupled power transfer technology

Capacitively coupled power transfer (CCPT) uses electrostatic mechanism to deliver power from a stationary transmitter to a mobile receiver. The authors study various aspects of this technology including physical limitations that are encountered to increase power transfer. They characterise the impact of input voltage, dielectric area, and permittivity of the dielectric material in realisation of CCPT system. It is observed that the peak voltage and VA ratings of the capacitors are affected by the choice of the aforementioned parameters. Air as a dielectric medium leads to low power density. A high permittivity material instead of air dielectric can be used to improve power density. This strategy will make the CCPT technology non-contactless, because a physical contact exists between the transmitter and receiver. However, this contact is different from an ohmic contact. A high power density CCPT system is realised using ceramic dielectric surfaces. Issues encountered in system realization are discussed including automatic resonant frequency tracking. Detailed mathematical models under resonance and off-resonance operation are proposed. The models are validated using simulations and experimental results. A low cost multilayer ceramic capacitor (MLCC) based high power-density transfer surface is realised. Results show that 35 W can be easily transferred using a set of 12 mm2 capacitive surfaces and 32 V source.
Social Stigma Against Mental Health: Educate, Protest, and Contact

Background: An important focus of mental health nursing is taking into consideration the role that stigmatization plays when directing a plan of care for current and future patients. Current research states that exposure and education about mental illnesses can reduce the occurrence of stigma surrounding them. A negative stigma surrounding mental illness severely lowers the individual to seek treatment for their mental health exacerbations. By taking time to understand mental health and the multiple disorders that fit into this category the public can lower stigma and stop the unintentional harm to their wellbeing. Purpose: The purpose of this review was to define stigma, explore the detrimental effects the stigma surrounding mental health has, and find ways to decrease social stigma. Method: An analysis of peer-reviewed journals and scholarly studies from multiple sources was done to obtain relevant information for this study. Findings: Findings show that the public has a negative view of those who are mentally ill, including thinking these people are dangerous, unpredictable, unreliable, and untreatable. Many studies revealed that the general population perceives mental illness as a separate issue from physical illness, when in fact physical illness and mental illness have more similarities than differences. Studies also revealed that people are not properly educated on how stigma impacts individuals with mental illness, even in terms of access and quality of healthcare. Conclusion: Based on these findings, healthcare workers of all walks and specialties must educate both their patients and others on the concepts of mental health to lower the negative stigma and control the lives of those with mental illness. Stigma is altered by protest, education, and contact.