Miracle-dz/UniFAR-FTUs huggingface dataset:
The evolution of agency-client relationships within the communication network in Italy: the perspective of communication partners

Purpose of the paper. Due to the digital revolution, the agency-client relationship has become more complex. Fitting into the recent academic literature on this topic, this study aims to deepen and conceptualise the agency-client relationship evolution in Italy. We adopted a twofold perspective: (i) “transversal”, to acquire the holistic vision of emerging issues of the new communication scenario and their consequent effects on the relational dynamics of agency-client for all the players (i.e., advertising and PR agency, media centre, digital agency) and (ii) “vertical”, to better emphasise the specificities of each category of the agency. Methodology. Qualitative exploratory research was conducted based on indepth interviews (n=53) with senior consultants belonging to different categories of players within the communication network. The data were analysed using qualitative content analysis and the cognitive mapping technique. Findings. By adopting the communication partners perspective, two interpretative frameworks were developed with respect to (1) key emerging issues that define the new communication scenario and (2) consequent effects on the evolution of the agency-client relationship. Specific themes emerged in the relational dynamics of the agency’s various categories. Research limits. This study shows the limits of qualitative research on the nonrepresentativeness of results. Practical implications. The holistic interpretation by the various actors of key issues that qualify the new scenario, along with the understanding of their consequent effects on agency-client relationships, could contribute to improving the performance of each player and, in this way, of the entire communication network. Originality of the paper. The study explores the agency-relationship evolution in Italy, a context that has still not been studied in-depth, while presenting relevant aspects of marketing communication. Additionally, the article proposes a twofold vision of the client-agency relationship evolution, i.e.”transversal” and “vertical”, for the first time.
Antigen-Specific Cytolysis by Neutrophils and NK Cells Expressing Chimeric Immune Receptors Bearing ζ or γ Signaling Domains

TCR- and IgG-binding Fc receptors (FcγR) mediate a variety of critical biologic activities including cytolysis via the structurally related ζ- and γ-chains. In previous studies, we have described chimeric immune receptors (CIR) in which the ligand-binding domain of a heterologous receptor or Ab is fused directly to the cytoplasmic domain of the TCR ζ-chain. Such ζ-CIRs efficiently trigger cytotoxic function of both T and NK cells in a target-specific manner. In this report, we compared the ability of both ζ- and γ-CIRs to activate the cytolytic function of two distinct classes of FcγR-bearing effectors, NK cells and neutrophils. Mature neutrophils expressing ζ- and γ-CIR were generated in vivo from murine hemopoietic stem cells following transplantation of syngeneic mice with retrovirally transduced bone marrow or in vitro from transduced human CD34+ progenitors following differentiation. Both ζ- and γ-based CIRs were capable of activating target-specific cytolysis by both NK cells and neutrophils, although the ζ-CIR was consistently more efficient. The experimental approach described is a powerful one with which to study the role of nonlymphoid effector cells in the host immune system and permits the rational design of immunotherapeutic strategies that rely on harnessing multiple immune cell functions via CIR-modified hemopoietic stem cells or progenitors.
Cross‐resistance of Cry1Ab‐selected Asian corn borer to other Cry toxins

The Asian corn borer, Ostrinia furnacalis (Guenée) (Lepidoptera: Crambidae), is the most important insect pest of maize in China. Despite the proven track record of biotech Bacillus thuringiensis (Bt) maize to provide an effective means to control lepidopteran pests such as the European corn borer Ostrinia nubilalis (Hübner), these crops have not been commercialized in China. However, Cry1Ab‐ and Cry1F‐expressing maize derived from genetic transformation events MON810 (Monsanto), Bt11 (Syngenta) and TC1507 (Pioneer, DuPont) as well as Cry1Ah‐, Cry1A‐ (a Cry1Ab/Cry1Ac hybrid toxin), and Cry1Ac‐, Cry1Ie‐expressing maize developed by the Chinese institutions have been shown to effectively suppress O. furnacalis in field trials. The development of resistance in target pests is a major threat to the use of Bt maize. A strain of O. furnacalis selected with Cry1Ab protein incorporated into artificial diet developed more than 100‐fold resistance to Cry1Ab after 35 generations of selection, and readily consumed Cry1Ab‐expressing maize silks. Although LC50s of the selected insect strain were not progressively increased, and even decreased in the following generations, these insects (ACB‐AbR) could survive on Cry1Ab‐expressing maize tissue after 51 generations of selection. In addition, susceptibility of ACB‐AbR to a number of other Bt toxins to which the selected strains had not previously been exposed, was significantly decreased. The highest level of cross‐resistance was observed with Cry1Ah (131‐fold), followed by Cry1Ac (36‐fold). A low level of cross‐resistance (6‐fold) to Cry1F was also detected. In contrast, ACB‐AbR was equally susceptible to Cry1Ie as the unselected control strain. These results indicate that the availability of multiple toxins could improve resistance management strategies, provided that the potential for cross‐resistance among toxins is not an issue.
Digital Outing Confidence as a Mediator in the Digital Behavior Regulation and Internet Content Awareness Relationship

The public digital outing refers to people creating and sharing personal information over the social media platforms. This specific digital outing behaviour is none of the less uniquely vulnerable to the negative effects of the digital public, triggering the individual's digital self-confidence injuring, and negatively impacting individual’s digital outing confidence. Starting from the assumption that the digital outing confidence might mediate the association between the IV internet content awareness and the DV digital behavioural regulation, we have investigated this relationship under a micro research driven from the database collected under the Erasmus+ project Hate’s Journey. Our team has designed an 18 items online questionnaire composed by single items measures, testing different opinions and perceptions related to the digital behaviour construct. Project team has collected 206 valid responses from resident individuals of Spain, Romania, Turkey and Latvia. Results confirm the partial mediation of digital outing confidence in the digital behaviour regulation and internet content awareness relationship. Conclusions and implications are discussed.
Phytochemical and anti-drepanocytosis studies of Cajanus cajan, Callistemon viminalis, Melaleuca bracteata var. Revolution Gold and Syzygium guineense.

All over Africa, traditional healers use medicinal plants to prepare medicines to treat a wide range of illnesses. One of these illnesses is sickle cell anaemia or drepanocytosis or sicklemia. This disease is particularly common among sub-Saharan Africans with a clear predominance in equatorial Africa. However, it also exists in North Africa, Greece, Turkey, Saudi Arabia and India. An estimated 50 million people are affected worldwide. A literature review on sickle cell anaemia revealed that a number of plants have anti-drepanocytosic activity. The availability and frequency of ethnobotanic use of plants were taken into account when selecting the plants investigated in this study. Cajanus cajan, Callistemon viminalis, Melaleuca bracteata var. Revolution Gold and Syzygium guineense (from DRC and South Africa) were selected for study. The selected plants were subjected to modern phytochemical analysis. A total of 8 compounds were isolated from the plants’ extracts and their structures determined by modern spectroscopic techniques (1D and 2D NMR, FT-IR and MS). S. guineense from DRC (Democratic Republic of Congo) yielded flavanonoid glycoside (A) as its major chemical constituent. The South African S. guineense afforded 4 compounds namely betulinic acid (B), sitosterol (C), friedelan-3-one (D) and a betulinic acid derivative (E). Cajanus cajan showed the presence of fatty acids, one of them was characterized as an unsaturated fatty acid (I). Callistemon viminalis afforded one compound, betulic acid (F) and Melaleuca bracteata afforded two compounds which were characterized as betulinic acid acetate (G) and ursolic acid acetate (H).
Persistence in the Realized Betas: Some Evidence for the Spanish Stock Market

This paper examines the stochastic behaviour of the realized betas within the one-factor CAPM for the six companies with the highest market capitalization included in the Spanish IBEX stock market index. Fractional integration methods are applied to estimate their degree of persistence at the daily, weekly and monthly frequency over the period 1 January 2000 – 15 November 2018 using 1, 3 and 5-year samples. On the whole, the results indicate that the realized betas are highly persistent and do not exhibit mean-reverting behaviour. However, the findings are rather sensitive to the choice of frequency and time span (number of observations).
Successful Medical Management of a Retroperitoneal Abscess: A Difficult Diagnosis in Pyrexia of Unknown Origin

Retroperitoneal abscesses are uncommon conditions with occult and insidious presentations. There is often a lack of abdominal signs and ultrasound findings, causing a delay in diagnosis and definitive treatment, leading to poor patient outcomes. We report a case of right-sided retroperitoneal abscess of a 28-year-old female patient with diabetes mellitus. Prior to admission, the patient reported a vague 2 weeks history of right-sided back and abdominal pain and dysuria. She presented to our medical ward with suspected pyelonephritis with right-sided renal abscess. A retroperitoneal abscess involving the right renal fossa was revealed on an urgent CT scan. The patient underwent percutaneous ultrasound-guided pigtail catheter drainage. Patient clinically and biochemically improved with medical management gradually over 2 weeks. This case report highlights the importance of investigating for recurrent urinary tract infections of diabetics which are often overlooked in general practice.
Antileishmanial Effects of Propolis Against Leishmania major In Vitro and In Vivo

Background: Propolis is produced by honey bees from plants, buds, and exudates and as an antiseptic is used to treat several dis-eases, such as acne and wounds. Objectives: Due to some diﬃculty in the treatment of cutaneous leishmaniasis, the aim of this study was to evaluate the propolis extract function against Leishmania major . Methods: Diﬀerentconcentrations(9.375,18.75,37.5,75,150,and300 µ g/mL)of bothEthanolicExtractof Propolis(EEP)andthestan-darddrug( Glucantime )werepreparedfortheinvitromodel,andthenappliedtotheﬁxednumberof promastigotes. Thepromastig-otes were counted after 24, 48, and 72-h treatment. Then, the viability of promastigotes was tested by MTT after 72 h of treatment. Twenty mice with cutaneous leishmaniasis were divided into four groups for in vivo model, including a positive group (treatment with Glucantime ), a negative group (without treatment), and two experimental groups (treatment with EEP 1% and 4%). The sizes of the ulcers were measured at the beginning of the experiment and weekly for four weeks. Results: The in vitro model indicated that both EEP and Glucantime reduced the number of promastigotes and the diﬀerence between EEP and Glucantime was not signiﬁcant at concentrations 37.5, 75, 150, and 300 µ g/mL. The in vivo model demonstrated that EEP 4% and Glucantime were similar and decreased the size of ulcers more signiﬁcantly than the negative control and EEP 1% (P < 0.05). Conclusions: Propolisasanherbaldrughadantileishmanialactivityagainst Leishmaniamajor invitroandinvivo. Wesuggestusing it for complementary treatment. polyphenols; benzoicacidsandderivatives; cinnamicalco-hol and cinnamic acid and its derivatives; sesquiterpene and triterpene hydrocarbons; benzaldehyde derivatives; other acids and respective derivatives; alcohols, ketones, and heteroaromatic compounds; terpene and sesquiterpene alcohols and their derivatives; aliphatic hydrocar-bons; minerals; sterols and steroid hydrocarbons; sugars
Nonstationary torsion problems for the finite cylinder partly coupled with rigid base

The axisymmetric dynamic problems of determining the stress state in the vicinity of the delamination in a finite cylinder partly coupled with the rigid base were solved. In contrast to the traditional solution methods based on the use of the integral Laplace transform, the proposed method consists in the difference approximation only of the time derivative. As a result, the original problem is replaced by a sequence of homogeneous boundary value problems for the Helmholtz equation that reduce to the Fredholm integral equation of the second kind. The numerical solution found made it possible to obtain an approximate formula for calculating the stress intensity factor.
The Importance of Ion Homeostasis and Nutrient Status in Seed Development and Germination

Seed is the dissemination unit of plants initiating an important stage in the life cycle of plants. Seed development, comprising two phases: embryogenesis and seed maturation, may define the quality of sown seed, especially under abiotic stress. In this review we have focused on the recent advances in the molecular mechanisms underlying these complex processes and how they are controlled by distinct environmental factors regulating ion homeostasis into the seed tissues. The role of transporters affecting seed embryogenesis and first stages of germination as imbibition and subsequent radicle protrusion and extension were revised from a molecular point of view. Seed formation depends on the loading of nutrients from the maternal seed coat to the filial endosperm, a process of which the efflux is not clear and where different ions and transporters are involved. The clear interrelation between soil nutrients, presence of heavy metals and the ion capacity of penetration through the seed are discussed in terms of ion effect during different germination stages. Results concerning seed priming techniques used in the improvement of seed vigor and radicle emergence are shown, where the use of nutrients as a novel way of osmopriming to alleviate abiotic stress effects and improve seedlings yield is discussed. Novel approaches to know the re-translocation from source leaves to developing seeds are considered, as an essential mechanism to understand the biofortification process of certain grains in order to cope with nutrient deficiencies, especially in arid and semiarid areas. Finally, the role of new genes involved in hormone-dependent processes, oxidative response and water uptake into the seeds during their development or germination, have been described as plant mechanisms to deal with abiotic stresses.
Monitoring oriental fruit moth (Lepidoptera: Tortricidae) with sticky traps baited with terpinyl acetate and sex pheromone

Studies in Argentina and Chile during 2010–2011 evaluated a new trap (Ajar) for monitoring the oriental fruit moth, Grapholita molesta (Busck). The Ajar trap was delta‐shaped with a jar filled with a terpinyl acetate plus brown sugar bait attached to the bottom centre of the trap. The screened lid of the jar was inserted inside the trap, and moths were caught on a sticky insert surrounding the lid. The Ajar trap was evaluated with and without the addition of a sex pheromone lure and compared with delta traps left unbaited or baited with a sex pheromone lure and a bucket trap filled with the same liquid bait. Studies were conducted in a sex pheromone‐treated orchard in Argentina and an untreated orchard in Chile. In Chile, the Ajar trap without the sex pheromone lure caught significantly fewer males, females and total moths than the bucket trap, and fewer males and more females than the sex pheromone‐baited delta trap. Total moth catch did not differ between the Ajar trap without a sex pheromone lure and the sex pheromone‐baited trap. Adding a sex pheromone lure to the Ajar trap significantly increased total moth catches to levels not different from those in the bucket trap. However, the Ajar trap with the sex pheromone lure caught significantly more males and fewer females than the bucket trap. In Argentina, the Ajar trap with or without the addition of a sex pheromone lure caught similar numbers of both sexes and total moths as the bucket trap. The sex pheromone‐baited delta trap caught <4% of the number of moths as these three traps. The bucket trap in both studies caught significantly more non‐targets than the delta and Ajar traps. Moth catches in the Ajar trap declined significantly after 2–3 weeks when the bait was not replaced.
Bridging the Fields of Careers and Project Management

Projects have become one of the most common ways of organizing work in organizations (Bakker, 2010; Bakker et al., 2016). They are the major means by which organizations structure and deliver both operational and strategic objectives (Chipulu et al., 2019; Ojiako et al., 2015), and projects also represent the means by which visions are operationalized (Maylor et al., 2018). Hence, projects are of insurmountable value to any organization (Parvan et al., 2015). In fact, scholars highlight that projects have evolved from being an organizational concern to playing a much more important role within society. As Jensen et al. (2016) observed, “Projects have become omnipresent not only in the economy but also in our society and our lives” (p. 21). In parallel, considering the scholarly development of research and teaching in project management, project management has clearly developed into a rich and multidisciplinary field of scientific research.
CAN CHOLECYSTECTOMY BE PERFORMED AS SAFELY IN ELDERLY PATIENTS AS IT IS IN YOUNG PATIENTS

88 Introduction: In this study, we aimed to compare the surgical outcomes between elderly and young patients undergoing surgery for gallstone disease and determine variations in patient characteristics, if any. Materials and Method: Data of patients who underwent surgery for gallstone disease at a single center between 2010 and 2018 were analyzed retrospectively. Two patient groups were evaluated: patients <65 years and ≥65 years. Patient characteristics, preoperative outpatient clinic data, surgical data, and postoperative data were collected. Results: In total, 1,198 patients with a mean age of 54.77 ± 15.03 (15–91) years were assessed. Comorbid conditions, including cardiovascular disease, pulmonary disease, renal disease, and diabetes mellitus were significantly more common in elderly patients (p<0.001). Acute cholecystitis in the preoperative period was noted in 15.36% of young patients and in 30.4% of elderly patients (p<0.001). Need for emergency surgery was higher in elderly patients than in young patients [13.86% (47) and 9.31% (80), respectively] (p=0.021). Laparoscopic cholecystectomy and open cholecystectomy were performed in 98.37% and 1.04% of young patients, respectively, and in 92.62% and 3.53% of elderly patients, respectively (p<0.001). Among factors affecting the length of hospital stay in elderly patients, the duration of hospitalization was significantly longer in elderly patients who underwent emergency surgery, open surgery, needed additional surgery, and who had high American Society of Anesthesiologists scores (p<0.001, p<0.001, p=0.013, p<0.001, respectively). Conclusion: Complications rates associated with cholecystectomy are similar between young and elderly patients when appropriate surgical preparations are performed. Surgery for gallstone disease can be performed safely in elderly patients with low morbidity and mortality rates.
BIOAVAILABILITY STUDY OF ONDANSETRON GEL IN RABBITS AND HUMAN VOLUNTEERS APPLING UPLC AS ANALYTICAL TOOL AND EVALUATION OF THE ANTIEMETIC EFFECT OF ONDANSETRON GEL IN CISPLATIN-INDUCED EMESIS IN RATS

Objective: This study was undertaken to determine the bioavailability of ondansetron gel in experimental animals and humans applying UPLC as an analytical tool and evaluation of the antiemetic effect of ondansetron gel in cisplatin-induced emesis in rats. Methods: Ondansetron gel (F13: sodium alginate 7% w/w) was used, marketed I. V. ondansetron (Zofran) ® was chosen as reference. The bioavailability study in rabbits was selected as a parallel design using nine healthy rabbits divided into three groups whereas, bioavailability study in humans was an open-label, wherein 6 healthy subjects administered ondansetron gel. The potential effect of ondansetron gel was evaluated for the prevention of different phases of emesis motivated by exposure to antineoplastic drugs (cisplatin) by determination of body weight loss, water and food intake applying kaolin-pica model in rats using seventy-two rats divided into six groups. Results: Ondansetron gel (0.5%) showed detectable plasma concentration 22.833±2.17 ng/m1 after ¼ h and 419.55±2.17 ng/ml after 1-h post-treatment in rabbits and human respectively and concentration was maintained above-reported minimum effective concentration for more than 2.5 h for rabbits and 7 h for humans compared to 1.75 h after I. V. administration. The ondansetron gel significantly reduces all phases of cisplatin-induced emesis and a decrease in body weight, water, and food consumption was significantly attenuated. Conclusion: Based on the high efficacy of gel on emesis induced by cisplatin, and its high bioavailability, transdermal ondansetron gel could be a promising convenient system to prevent nausea and vomiting following administration of antineoplastic drugs.
Is There a Nascent Plate Boundary in the Northern Indian Ocean?

The northern Indian Ocean has been widely recognized as an area of broadly distributed deformation within the composite India‐Australia‐Capricorn plate, hosting several diffuse boundary zones and a diffuse triple junction. The occurrence, along reactivated fracture zones, of the exceptionally large (Mw = 8.6 and Mw = 8.2) 2012 Wharton Basin strike‐slip earthquakes, however, questions whether this composite plate is breaking apart along a discrete boundary. Using recent bathymetric and seismic data, we analyze the most prominent fracture zone (F6a), whose structural trace is particularly well expressed. We identify 60 kilometric‐scale pull‐apart basins with geometric properties (length/width ratios) similar to those observed along continental strike‐slip plate boundaries. Four of the pull‐aparts formed above narrow, subvertical faults extending into the oceanic crust. Within the broad Wharton deformation zone, the significant slip rates (0.8 to 2.5 mm/yr) and unusually large coseismic displacements recorded along F6a suggest that it may be a nascent plate boundary.
Interpretation of soil phosphorus availability by Mehlich-3 in soils with contrasting phosphorus buffering capacity

ABSTRACT Increasingly rational use of phosphate fertilizers by agriculture is important, especially in Brazil, due to its importance for global food security and its high dependence on phosphate fertilizers for crop production. Thus, correlation and calibration researches with soil available phosphorus (P) extractants to improve the recommendation and the use of P are extremely important. Our objectives were (i) to determine soil P recovery rates and critical levels by the extractants Mehlich-1 (M1), Mehlich-3 (M3), and Ion Exchange Resin (RTI); [. ]