Miracle-dz/UniFAR-FTUs huggingface dataset:
Positioning performance of single-frequency GNSS receiver using Australian regional ionospheric corrections

The thesis focuses on developing and validating a method that allows low-cost single-frequency GPS devices to improve the navigation accuracy of 5 to 10 metres to the submetre level. The method is based on the estimation of regional ionospheric corrections using widely distributed GPS stations in Australia. Mass-market users, such as smartphones and vehicle users can benefit from the developed approach.
Evaluation of Surgical Site Infection After Elective Surgeries at a Tertiary Care Hospital

Surgical site infections (SSI) are commonly seen in surgical practice and are the main cause for concern in post-operative patients. There are many risk factors that predispose to the development of SSI. However, the occurrence of SSI in patients undergoing elective class I and class II surgeries, which are considered clean surgeries with minimal contamination, is an important issue bothering the surgeons. SSI are also responsible for increased morbidity due to wound dehiscence, thus prolonging hospital stays and often leading to inconvenience to patients. We hereby present a study to highlight and address this important issue of SSI in our institute. All patients above 12 years of age who underwent elective class I and class II surgeries in the department of general surgery were included in this observational study. After surgery, local examination of the incision or wound site and grading of the SSI were done using the Southampton Wound Grading System (SWGS). Our results showed that 90% of the patients had normal healing, according to SWGS. We found that the incidence of SSI was lower in patients who underwent alternate-day dressing of their wound as compared to daily dressing. Another interesting finding was that the incidence of SSI was lower in patients in whom wound dressing was done with transparent film dressing as compared to povidone-iodine-guaze dressing. We concluded our study by finding that the incidence of SSI after elective class I and class II surgeries in our hospital was quite low, at 10%.
Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties

Moringa oleifera (M. oleifera) is a tropical tree native to Pakistan, India, Bangladesh, and Afghanistan; it is cultivated for its nutritious leaves, pods, and seeds. This scientific study was conducted to outline the anti-inflammatory properties and mechanisms of action of bioactive compounds from M. oleifera. The existing research has found that the plant is used in traditional medicine due to its bioactive compounds, including phytochemicals: flavonoids and polyphenols. The compounds are thought to exert their anti-inflammatory effects due to: (1) inhibition of pro-inflammatory enzymes: quercetin and kaempferol inhibit the pro-inflammatory enzymes (cyclooxygenase and lipoxygenase); (2) regulation of cytokine production: isothiocyanates modulate signaling pathways involved in inflammation, such as the nuclear factor-kappa B (NF-kappa B) pathway; isothiocyanates inhibit the production of pro-inflammatory cytokines such as TNF-α (tumor necrosis factor α) and IL-1β (interleukin-1β); and (3) antioxidant activity: M. oleifera contains flavonoids, polyphenols, known to reduce oxidative stress and inflammation. The review includes M. oleifera’s effects on cardiovascular protection, anti-hypertensive activities, type 2 diabetes, inflammatory bowel disease, and non-alcoholic fatty liver disease (NAFLD). This research could prove valuable for exploring the pharmacological potential of M. oleifera and contributing to the prospects of developing effective medicines for the benefit of human health.
The effect of sublethal doses of Bacillus thuringiensis Berliner on Tuta absoluta (Meyrick) on resistant and susceptible tomato cultivars

The effect of Bacillus thuringiensis ( Bt ) Berliner on the Tuta absoluta (Meyrick) on two resistant (‘King Stone’) and susceptible (‘Rio Grande’) tomato ( Solanum lycopersicum L.) cultivars was studied under laboratory conditions. In the bioassay tests, the lethal concentration (LC 50 ) values of Bt were determined for the 2nd-and 3rd-instar larvae of T. absoluta on two cultivars. In another experiment, the effect of sublethal doses of Bt on 2nd-and 3rd-instar larvae on two susceptible and resistant cultivars was determined. Also, the nutritional indices and the enzyme content of larvae on two susceptible and resistant cultivars under the sublethal doses of Bt were investigated. All nutritional indices and the enzyme content of the treated larvae were significantly different compared to those of the control group. The lowest efficiency of the conversion of ingested food (7.82%), the efficiency of the conversion of digested food (4.34%), the relative consumption rate (22.29 mg mg −1 day −1 ), and the relative growth rate (1.16 mg mg −1 day −1 ) was determined for the resistant cultivar ‘King Stone’ at the LC 25 concentration of Bt . The lowest amount of α-amylase (0.98 nM min −1 mg −1 protein), protease (12.61 µM min −1 mg −1 protein), and lipase (0.182 nM min −1 mg −1 protein) and the highest amount of phenoloxidase (0.337 µM min −1 mg −1 protein) were determined for the resistant cultivar ‘King Stone’ at the LC 25 concentration of Bt . The results showed that the integration of Bt application and host plant resistance significantly increased the efficiency of Bt .
Effect of wildfire and fireline construction on the annual depth of thaw in a black spruce permafrost forest in interior Alaska: a 36-year record of recovery

Maximum thaw depths were measured annually in an unburned stand, a heavily burned stand, and a fireline in and adjacent to the 1971 Wickersham fire. Maximum thaw in the unburned black spruce stand ranged from 36 to 52 cm. In the burned stand, thaw increased each year to a maximum depth of 302 cm in 1995. In 1996, the entire layer of seasonal frost remained, creating a new active layer depth at 78 cm. An unfrozen soil zone (talik) remained between the two frozen layers until 2006 when the entire profile remained frozen. Permafrost returned to the burned site by the formation of a layer of seasonal frost that remained frozen through subsequent years. The fireline displayed a similar pattern with a maximum thaw of 266 cm in 1995 and the establishment of a continuous frozen layer at 69 cm, but the upper frozen layer became discontinuous after several years.
A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies

ABSTRACT Ieramilimab, a humanized anti-LAG-3 monoclonal antibody, was well tolerated in combination with the anti-PD-1 antibody spartalizumab in a phase 1 study. This phase 2 study aimed to further investigate the efficacy and safety of combination treatment in patients with selected advanced (locally advanced or metastatic) solid malignancies. Eligible patients with non-small cell lung cancer (NSCLC), melanoma, renal cell carcinoma (RCC), mesothelioma, and triple-negative breast cancer (TNBC) were grouped depending on prior anti-PD-1/L1 therapy (anti-PD-1/L1 naive or anti-PD-1/L1 pretreated). Patients received ieramilimab (400 mg) followed by spartalizumab (300 mg) every 3 weeks. The primary endpoint was objective response rate (ORR), along with safety, pharmacokinetics, and biomarker assessments. Of 235 patients, 142 were naive to anti-PD-1/L1 and 93 were pretreated with anti-PD-1/L1 antibodies. Durable responses (>24 months) were seen across all indications for patients naive to anti-PD-1/L1 and in melanoma and RCC patients pretreated with anti-PD1/L1. The most frequent study drug-related AEs were pruritus (15.5%), fatigue (10.6%), and rash (10.6%) in patients naive to anti-PD-1/L1 and fatigue (18.3%), rash (14.0%), and nausea (10.8%) in anti-PD-1/L1 pretreated patients. Biomarker assessment indicated higher expression of T-cell-inflamed gene signature at baseline among responding patients. Response to treatment was durable (>24 months) in some patients across all enrolled indications, and safety findings were in accordance with previous and current studies exploring LAG-3/PD-1 blockade.
Data Report: Microprobe analyses of primary phases (olivine, pyroxene, and spinel) and alteration products (serpentine, iowaite, talc, magnetite, and sulfides) in Holes 1268A, 1272A, and 1274A

Primary and secondary mineral phases from Holes 1268A (11 samples), 1272A (9 samples), and 1274A (12 samples) were analyzed by electron microprobe in Bonn and Cologne (Germany) (Table T1). Bulk rock powders of these samples were also analyzed geochemically, including major and trace elements (Paulick et al., 2006). Ocean Drilling Program (ODP) Leg 209 Holes 1268A, 1272A, and 1274A differ remarkably in alteration intensity and mineralogy, and details regarding their lithologic characteristics are presented in Bach et al. (2004) and Shipboard Scientific Party (2004). Hole 1274A contains the least altered peridotite drilled during Leg 209; however, the abundance of serpentine-brucite-magnetite assemblages increases from 60 to >95 vol% downhole. In Hole 1272A, completely serpentinized harzburgite consists of serpentine-magnetite ± brucite ± iowaite assemblages. Iowaite (Mg4[OH]8FeOCl·1–4[H2O]) has been described previously from submarine mud volcanoes (Heling and Schwarz, 1992) and serpentinites at the Iberian margin (Gibson et al., 1996). Hole 1272A represents the first documented occurrence of this mineral as a replacive phase in a mid-ocean-ridge setting (Shipboard T1. Mineral analyses, p. 10.
The Effect of Implementing Environmental Management Accounting on Environmental Performance (Empirical Study of Public Companies Based on the Company Performance Assessment Progamme in Environmental Management / PROPER Listed on the Indonesian Stock Exchange for the 2016-2017 Period)

This research examines the effect of implementing environmental management accounting on environmental performance. Environmental management accounting is measured by the effectiveness and efficiency of environmental cost control in looking at the effect on improving environmental performance as measured by the PROPER score. The population in this research are public companies that use renewable resources and carry out operational activities from 2016 to 2022. The data analysis technique used in this research is comparative and quantitative analysis using multiple linear regression analysis using SPSS version 25. This research uses a sample of 42 companies. Samples were selected from 2016 to 2022 using the purposive sampling method. The results of this research show that the effectiveness and efficiency of environmental cost control as a measuring tool for the implementation of environmental management accounting have a positive and significant effect on environmental performance as measured by the PROPER score.
Analysis of the application of information technology systems and employee performance

The development of information technology requires an apparatus that is always fast and responsive in anticipating changes. Moreover, technology is also one of the keys to boosting the competitiveness of human resources in the instrument, which is currently getting tighter. The purpose of this study is to determine the influence of talent management and the quality of human resources on employee performance through the application of information technology systems. The research approach used in this study is quantitatively based on the study of empirical rational principles. The data collection techniques used are questionnaires. The sample consisted of 93 respondents. Data analysis used is descriptive analysis, data quality test, and hypothesis testing. The results of research on the influence of talent management and the quality of human resources on employee performance through the application of information technology systems at the BP PAUD and Dikmas offices of South Sulawesi Province show that talent management, human resource quality, and the application of information technology systems have a direct effect on performance. Of course, suppose the BP PAUD and Dikmas offices consistently apply talent management that has been done so far and pay attention to the quality of each employee they have and increasingly utilize information technology systems as work aids.
FOXP3+ regulatory T cells are associated with the severity and prognosis of sarcoidosis

Rationale Sarcoidosis is an inflammatory granulomatous disease of unknown etiology with predominant lung involvement. Organ involvement and disease severity, as well as the nature of immune alterations, vary among patients leading to a range of clinical phenotypes and outcomes. Our objective was to evaluate the association of disease course and immune responses in pulmonary sarcoidosis. Methods In this prospective cohort study of 30 subjects, most of whom were followed for one year, we evaluated 14 inflammatory markers in plasma, 13 Treg/T cell flow cytometry markers and 8 parameters of FOXP3+ Treg biology, including suppressive function, epigenetic features and stability. Results We identified a set of 13 immunological parameters that differ in sarcoidosis subjects in comparison with healthy donors. Five of those were inversely correlated with suppressive function of Tregs in sarcoidosis, and six (TNFα, TNFR I and II, sCD25, Ki-67 and number of Tregs) were particularly upregulated or increased in subjects with thoracic lymphadenopathy. Treg suppressive function was significantly lower in patients with thoracic lymphadenopathy, and in patients with higher burdens of pulmonary and systemic symptoms. A combination of five inflammatory markers, Ki-67 expression, Treg function, and lung diffusion capacity evaluated at study entry predicted need for therapy at one year follow-up in 90% of cases. Conclusion Tregs may suppress ongoing inflammation at local and systemic levels, and TNFα, TNFR I and II, sCD25 and Ki-67 emerge as attractive biomarkers for in vivo sarcoid inflammatory activity.
Methane Emission, Carbon Footprint and Productivity of Specialized Dairy Cows Supplemented with Bitter Cassava (Manihot esculenta Crantz)

Simple Summary The objective of this research was to determine the effect of cassava (Manihot esculenta Crantz) supplementation on enteric methane emissions, carbon footprint, and production parameters in dairy cows. Cassava roots and leaves replaced up to 30% of the daily supply of commercial concentrate for two Jersey and Jersey * Holstein breeds. Cassava leaves were characterized by a high crude protein content, with five times more neutral detergent fiber content than cassava root. Average enteric methane emissions per animal ranged from 194 to 234 g/d. The carbon footprint was reduced by replacing 30% of the concentrate with cassava leaves and/or roots. Energy-corrected milk production was 1.15 times higher in Jersey * Holstein animals than in Jersey cows. Therefore, supplementation with cassava leaves and/or roots is a nutritionally and environmentally sustainable strategy to replace external grain concentrates used in these systems. Abstract The objective of this research was to determine the effect of cassava (Manihot esculenta Crantz) supplementation on enteric methane (CH4) emissions, carbon footprint, and production parameters in dairy cows. Daily concentrate supply for Jersey and Jersey * Holstein breeds was evaluated in four treatments (T): T1: 100% commercial concentrate; T2: 70% concentrate + 30% cassava leaves; T3: 70% concentrate + 30% cassava roots; and T4: 70% concentrate + 15% cassava leaves + 15% cassava root chips. Measurements of CH4 emissions were performed using the polytunnel technique. Average daily dry matter intake ranged from 7.8 to 8.5 kg dry matter (DM). Cassava leaves were characterized by a high crude protein (CP) content (171 g CP/kg DM), with 5 times more neutral detergent fiber (NDF) content than cassava root (587 vs. 108 g NDF/kg DM). Average enteric CH4 emissions per animal ranged from 194 to 234 g/d (p > 0.05). The carbon footprint was reduced by replacing 30% of the concentrate with cassava leaves and/or roots. Energy-corrected milk production was 1.15 times higher in Jersey * Holstein animals than Jersey cows (47 vs. 55 kg). Therefore, supplementation with cassava leaves and/or roots is a nutritionally and environmentally sustainable strategy.
Recognizing Stakeholders and Factors Mediating Washback in Language Testing

Any test or assessment’s effect on teaching and learning is termed as “washback”. Empirical studies conducted in this area are relatively recent, starting with the remarkable work of Alderson and Wall in 1993. Studies conducted thereafter inquired into different aspects of washback. In light of these studies, this critical review would explore the stakeholders of washback and the factors outside of the test itself which could affect how it has an impact. It indicates that although a test’s washback remains at the core of the complex connection among classroom teaching, learning, and assessment, a test cannot solely lead the classroom teaching and learning; rather, it is intervened by the different overriding agents, e.g., teachers, students, and contexts shaped by them. Notwithstanding that, teachers are the ones who can maintain a leading role in generating positive washback of target tests. In the end, this article draws suggestions from the literature showing what teachers should do to warrant a positive washback.
Training on Installation and Use of Woocomerce in Developing MSME Product Marketing in Palembang City

Improving the economy and competitiveness of Micro, Small, and Medium Enterprises (MSMEs) is the main focus in regional development, including in the City of Palembang. In the context of globalization and digitalization, e-commerce platforms such as WooCommerce have become a potential tool for expanding the market reach of MSMEs. This activity aims to provide understanding and skills to MSME actors in installing, configuring and managing online stores using WooCommerce as a marketing development tool for MSME products in Palembang City. In this context, the main problem formulation is the extent to which MSME players understand and master WooCommerce, the obstacles they face in using it, and the impact of training on increasing competitiveness, product sales and local economic growth. The methods used in this activity are by using training methods, surveys and data analysis. This activity is expected to help MSMEs utilize the potential of WooCommerce to the maximum. Apart from that, this research also measures the positive effects of training in terms of creating new jobs and regional economic growth. It is hoped that the results of this activity can provide guidance for MSME players and stakeholders in developing the marketing of MSME products in Palembang City through e-commerce platforms. Then the socialization results were published on Poltekbang Palembang social media and community service journals. So, it can be concluded from the results of this activity that all participants are able to create online stores in accordance with the guidelines and can increase sales.
Congenital Tumors—Magnetic Resonance Imaging Findings with Focus on Rare Tumors

Simple Summary Congenital tumors are an uncommon finding on prenatal ultrasound and in the first 3 months of life, and they are (almost) always subjected to magnetic resonance imaging. Although they are usually easy to recognize as pathological masses, differential diagnosis is not easy and includes both benign and malignant conditions. Teratomas are the most frequent group of inborn neoplasms, followed by cardiac rhabdomyomas. In this paper, the authors show a series of cases in order to provide tips to identify the more common masses and to keep in mind that the most unusual tumor may occur as congenital and that no diagnosis should be rejected a priori. The article is intended to raise awareness and draw attention to this little-known group of cancers and facilitate the diagnostic process. Abstract Congenital tumors are rare and, owing to this rarity, there is limited information on many of them. A total of 839 fetal and postnatal MRI studies performed in the first 3 months of life were retrospectively reviewed. They were performed with the use of 1.5 T scanners. Seventy-six tumors were diagnosed based on fetal MRI between 20 and 37 gestational weeks, and 27 were found after birth, from 1 day of age to 3 months of life. Teratomas were the most common tumors in our dataset, mainly in the sacrococcygeal region (SCT), followed by cardiac rhabdomyomas and subependymal giant cell astrocytomas (SEGA) associated with TSC, and neuroblastomas. The group of less common tumors consisted of infantile fibrosarcomas, malignant rhabdoid tumors, mesoblastic nephromas and Wilms tumor, craniopharyngiomas, brain stem gliomas, desmoplastic infantile astrocytoma, choroid plexus carcinoma, glioblastoma, hemangiopericytoma, rhabdomyosarcoma, melanoma, mesenchymal hamartomas of the chest wall and the liver, and juvenile xanthogranuloma, with special consideration of blue rubber bleb nevus syndrome. MRI plays a significant role in further and better characterization of congenital tumors, leading to a correct diagnosis in many cases, which is crucial for pregnancy and neonatal management and psychological preparation of the parents. No diagnosis is impossible and can be absolutely excluded.
Actionable Driver Events in Small Cell Lung Cancer

Small cell lung cancer (SCLC) stands out as the most aggressive form of lung cancer, characterized by an extremely high proliferation rate and a very poor prognosis, with a 5-year survival rate that falls below 7%. Approximately two-thirds of patients receive their diagnosis when the disease has already reached a metastatic or extensive stage, leaving chemotherapy as the remaining first-line treatment option. Other than the recent advances in immunotherapy, which have shown moderate results, SCLC patients cannot yet benefit from any approved targeted therapy, meaning that this cancer remains treated as a uniform entity, disregarding intra- or inter-tumoral heterogeneity. Continuous efforts and technological improvements have enabled the identification of new potential targets that could be used to implement novel therapeutic strategies. In this review, we provide an overview of the most recent approaches for SCLC treatment, providing an extensive compilation of the targeted therapies that are currently under clinical evaluation and inhibitor molecules with promising results in vitro and in vivo.
Effectiveness of Partial Body Weight-Supported Treadmill Training on Various Outcomes in Different Contexts among Children and Adolescents with Cerebral Palsy: A Systematic Review and Meta-Analysis

The efficiency of partial body weight-supported treadmill training (PBWSTT) for treating various conditions in children and adolescents with cerebral palsy (CP) in diverse contexts of rehabilitation, households, or schools is unknown. The major objective of this systematic review and meta-analysis was to analyze the effectiveness of PBWSTT on various outcomes in different contexts among children and adolescents with CP. We incorporated full-text, randomized controlled trial studies that specifically assessed the effects of PBWSTT walking, motor function, stride, balance, and endurance in children and adolescents aged 3 to 18 years with CP. The literature search was carried out using Google Scholar, PubMed, Web of Science, CINAHL Plus, Scopus, PEDro, and ResearchGate databases. The methodological quality was evaluated using a Cochrane risk of bias instrument. A meta-analysis of pooled data from 10 studies with 255 participants demonstrated that PBWSTT for 4–12 weeks in rehabilitation (mean difference [MD] = 1.94, 95% confidence interval [CI] = 1.40—2.48, p < 0.0001), at home or in a school context (MD = 13.5, 95% CI = 13.9—16.0, p < 0.0001), was significantly effective for treating various conditions in children and adolescents suffering with CP. The period of 4–12 weeks of PBWSTT in rehabilitation and at-home/school settings is effective on various outcomes in children or adolescents with CP.