Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of sleep quality and sleep duration with serum uric acid levels in adults

Objective To date, the association between sleep duration or sleep quality and hyperuricemia has remained unclear. In addition, sleep duration and quality were not considered concomitantly in previous studies. Thus, this study was aimed toward an examination of the association of sleep duration and quality with uric acid level in a Taiwanese population. Methods A total of 4,555 patients aged ≥18 years were enrolled in this study. The sleep duration was classified into three groups: short (<7 h), normal (7–9 h), and long (≥9 h). The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and poor sleep quality was defined as a global PSQI score of >5. Results Poor sleepers were younger and had lower body mass index, blood pressure, uric acid, blood sugar, cholesterol, creatinine level, shorter sleep duration, and engaged in less exercise but had a higher white blood cell count and prevalence of smoking as compared to good sleepers. There were also differences in body mass index, blood pressure, uric acid, blood sugar, lipid profiles, and sleep quality among subjects with different sleep durations. After adjusting for other variables, poor sleep quality was associated with lower uric acid levels. In addition, short sleep duration was positively associated with higher uric acid levels. Conclusions Poor sleep quality was related to lower uric acid levels, whereas short sleep duration was associated with higher uric acid levels.
Effects of dietary choline on liver lipid composition, liver histology and plasma biochemistry of juvenile yellowtail kingfish (Seriola lalandi)

Abstract Choline plays a crucial role in lipid metabolism for fish, and its deficiency in aquafeed has been linked to compromised health and growth performance. A 56-d experiment was conducted to examine the effects of dietary choline on lipid composition, histology and plasma biochemistry of yellowtail kingfish (Seriola lalandi; YTK; 156 g initial body weight). The dietary choline content ranged from 0·59 to 6·22 g/kg diet. 2-Amino-2-methyl-1-propanol (AMP) (3 g/kg) was added to diets, except for a control diet, to limit de novo choline synthesis. The results showed that the liver lipid content of YTK was similar among diets containing AMP and dominated by NEFA. In contrast, fish fed the control diet had significantly elevated liver TAG. Generally, the SFA, MUFA and PUFA content of liver lipid in fish fed diets containing AMP was not influenced by choline content. The SFA and MUFA content of liver lipid in fish fed the control diet was similar to other diets except for a decrease in PUFA. The linear relationship between lipid digestibility and plasma cholesterol was significant, otherwise most parameters were unaffected. When AMP is present, higher dietary choline reduced the severity of some hepatic lesions. The present study demonstrated that choline deficiency affects some plasma and liver histology parameters in juvenile YTK which might be useful fish health indicators. Importantly, the present study elucidated potential reasons for lower growth in choline-deficient YTK and increased the knowledge on choline metabolism in the fish.
Urinary neprilysin for early detection of acute kidney injury after cardiac surgery

BACKGROUND Acute kidney injury (AKI) predicts adverse outcomes after cardiac surgery. The accuracy of using changes in serum creatinine for diagnosis and grading of AKI is limited in the peri-operative cardiac surgical setting and AKI may be underdiagnosed due to haemodilution from cardiopulmonary bypass priming and the need for intra-operative and postoperative volume resuscitation. OBJECTIVES To determine whether the urinary biomarker neprilysin can be used as a marker for the early detection of AKI after cardiac surgery. DESIGN Prospective, observational cohort study. SETTING Austrian tertiary referral centre. PATIENTS 96 Patients undergoing elective cardiac surgery with cardiopulmonary bypass. MAIN OUTCOME MEASURES Differences and discriminatory power of neprilysin levels early after cardiac surgery and on postoperative day 1 between patients with or without AKI, as defined by the Kidney Disease Improving Global Outcomes Group. RESULTS AKI was found in 27% (n=26). The median neprilysin levels on postoperative day 1 were significantly higher in the AKI than in the non-AKI group, 4.0 [interquartile range (IQR): 2 to 6.25] vs. 2.0 ng ml−1 [IQR: 1.0 to 4.5], P = 0.0246, respectively. In addition, the median neprilysin levels at the end of surgery were significantly different between both groups, 5.0 [IQR: 2.0 to 9.0] vs. 2.0 ng ml−1 [IQR: 1.0 to 4.0], P = 0.0055, respectively. The discriminatory power of neprilysin for detecting early AKI corresponded to an area under the curve of 0.77 (95% confidence interval, 0.65 to 0.90). CONCLUSION Urinary neprilysin has potential as a biomarker for the early detection of AKI after cardiac surgery and has comparable discriminatory power to recently studied AKI biomarkers. TRIAL REGISTRATION The trial was registered at ClinicalTrials.gov (NCT03854825, https://clinicaltrials.gov/ct2/show/NCT03854825).
PRECISE-DAPT score for bleeding risk prediction in patients on dual or single antiplatelet regimens: insights from the GLOBAL LEADERS and GLASSY.

AIMS The 5-item PRECISE-DAPT, integrating age, haemoglobin, white-blood-cell count, creatinine clearance, and prior bleeding, predicts bleeding risk in patients on dual antiplatelet therapy (DAPT) after stent implantation. We sought to assess whether the bleeding risk prediction offered by the PRECISE-DAPT remains valid among patients receiving ticagrelor monotherapy from 1 month onwards after coronary stenting instead of standard DAPT and having or not having centrally-adjudicated bleeding endpoints. METHODS AND RESULTS The PRECISE-DAPT was calculated in 14,928 and 7,134 patients from GLOBAL LEADERS and GLASSY trials, respectively. The ability of the score to predict BARC 3 or 5 bleeding was assessed and compared among patients on ticagrelor monotherapy (experimental strategy) or standard DAPT (reference strategy) from 1 month after drug-eluting stent implantation. Bleeding endpoints were investigator-reported or centrally-adjudicated in GLOBAL LEADERS and GLASSY, respectively.At 2 years, the c-indexes for the score among patients treated with the experimental or reference strategy were 0.67 (95% confidence interval [CI]:0.63-0.71) vs. 0.63 (95% CI:0.59-0.67) in GLOBAL LEADERS (p = 0.27), and 0.67 (95% CI:0.61-0.73) vs. 0.66 (95% CI:0.61-0.72) in GLASSY (p = 0.88). Decision curve analysis showed net benefit using the PRECISE-DAPT to guide bleeding risk assessment under both treatment strategies. Results were consistent between investigator-reported and adjudicated endpoints and using the simplified 4-item PRECISE-DAPT. CONCLUSIONS The PRECISE-DAPT offers a prediction model that proved similarly effective to predict clinically-relevant bleeding among patients on ticagrelor monotherapy from 1 month after coronary stenting compared with standard DAPT and appears to be unaffected by the presence or absence of adjudicated bleeding endpoints.
Obese COVID‐19 patients show more severe pneumonia lesions on CT chest imaging

Variables Normal weight Overweight Obese Underweight F/χ value P (n = 84, 36.4%) (n = 105, 45.4%) (n = 33, 14.3%) (n = 9, <0.1%) Age, years 43.1 ± 14.2 47.7 ± 12.0 44.8 ± 13.3 49.1 ± 13.7 2.2 . 1 Female/male patients (%) 39/45 (46.4) 43/62 (41.0) 9/24 (27.3) 3/6 (33.3) 3.8 . 3 Onset to hospitalization, days 6.8 ± 6.2 7.0 ± 6.4 6.0 ± 6.1 6.9 ± 5.7 0.2 . 9 Diabetes, yes/no (%) 5/79 (6.0) 6/99 (5.7) 1/32 (3.0) 1/8 (11.1) 0.9 . 6 Hypertension, yes/no (%) 8/76 (9.5) 15/90 (14.3) 4/29 (12.1) 0/9 (0) 2.3 . 7 Cardiovascular disease, yes/no (%) 1/83 (1.2) 3/102 (2.9) 0/33 (0) 0/9 (0) 1.7 . 5 Hyperlipidaemia, yes/no (%) 0/84 (0) 1/104 (1.0) 2/31 (6.1) 0/9 (0) 7.2 . 1 Liver disease, yes/no (%) 3/81 (3.6) 2/103 (1.9) 0/33 (0) 0/9 (0) 1.7 . 2 Cancer, yes/no (%) 1/83 (1.2) 1/104 (1.0) 0/33 (0) 0/9 (0) 0.5 . 5 Lung-related disease, yes/no (%) 2/82 (2.4) 1/104 (1.0) 1/32 (3.0) 0/9 (0) 1.1 . 5 C-reactive protein, mg/L 13.1 ± 22.4 20.5 ± 23.8 30.1 ± 29.0 18.7 ± 22.7 4.1 . 01* Whole lung, mm Total lesion 99.4 ± 142.9 193.9 ± 267.9 251.3 ± 348.6 191.7 ± 220.3 3.9 . 01* Whole GGO 76.7 ± 117.0 146.1 ± 205.1 192.1 ± 259.2 173.5 ± 210.3 3.9 . 01* Whole consolidation 22.6 ± 37.1 47.8 ± 76.8 59.2 ± 111.1 18.2 ± 20.4 3.2 . 02* Right superior lobe, mm Total lesion 8.6 ± 29.2 32.2 ± 81.2 48.0 ± 86.2 19.6 ± 34.8 3.4 . 02* GGO 7.5 ± 26.6 25.8 ± 65.5 36.6 ± 63.4 18.7 ± 33.1 3.0 . 03* Consolidation 1.1 ± 3.8 6.3 ± 20.5 11.4 ± 27.7 0.9 ± 1.8 3.2 . 02* Right middle lobe, mm . 03 Total lesion 3.0 ± 10.6 7.4 ± 19.7 11.9 ± 21.3 1.8 ± 2.4 2.7 . 05 GGO 2.6 ± 9.2 6.4 ± 17.3 10.0 ± 17.4 1.7 ± 2.3 2.5 . 06 Consolidation 0.3 ± 1.7 1.0 ± 3.1 1.9 ± 4.9 0.1 ± 0.1 2.4 . 07 Right inferior lobe (mm) Total lesion 42.1 ± 62.0 69.8 ± 94.2 90.8 ± 113.7 85.6 ± 96.6 3.2 . 03* GGO 31.6 ± 48.0 48.7 ± 65.8 68.5 ± 82.7 72.4 ± 80.3 3.4 . 02* Consolidation 10.5 ± 20.1 21.1 ± 34.2 22.4 ± 40.4 13.3 ± 19.6 2.3 . 08 Left superior lobe, mm Total lesion 9.5 ± 24.5 27.0 ± 55.0 39.6 ± 72.4 23.6 ± 38.0 3.6 . 01* GGO 7.9 ± 21.9 22.2 ± 45.8 32.9 ± 60.5 23.1 ± 37.5 3.5 . 02* Consolidation 1.6 ± 4.3 4.7 ± 12.9 6.7 ± 16.7 0.5 ± 0.5 2.4 . 07 Left inferior lobe, mm Total lesion 36.1 ± 58.0 57.5 ± 86.4 61.0 ± 88.9 61.1 ± 97.4 1.5 . 2 GGO 27.1 ± 45.4 42.8 ± 66.9 44.1 ± 61.8 57.5 ± 94.7 1.6 . 2 Consolidation 9.0 ± 16.8 14.7 ± 22.6 16.8 ± 33.9 3.5 ± 4.0 1.9 . 1
Work participation and risk factors for health-related job loss among older workers in the Health and Employment after Fifty (HEAF) study: Evidence from a 2-year follow-up period

Introduction Rapidly increasing population old age dependency ratios create a growing economic imperative for people to work to older ages. However, rates of older worker employment are only increasing slowly. Amongst a cohort of contemporary older workers, we investigated risk factors for health-related job loss (HRJL) over 2 years of follow-up. Methods HEAF is a population based cohort study of adults in England (aged 50–64 years at baseline) who provided information about socio-demographic characteristics, lifestyle, and work at baseline and annual follow-ups. Exits from paid work were mapped and risk factors for HRJL explored in a multiple-record survival dataset by Cox proportional hazards models. Results 2475 (75%) men and 2668 (66%) women were employed; 115 (4.6%) men and 182 (6.8%) women reported HRJL. Employment as road transport drivers/in vehicle trades (men), or as teaching/education/nursing/midwifery professionals or in caring personal services (women), was more frequent among people exiting work for health-related versus non-health-related reasons. Principal socio-demographic and lifestyle risk factors for HRJL were: struggling financially (men and women); low physical activity (men); being overweight or obese, and current smoking (women). Mutually adjusted work-related risk factors for HRJL were job dissatisfaction, and not coping with the physical (hazard ratio [95% confidence interval]: men 5.34[3.40,8.39]; women 3.73[2.48,5.60]) or mental demands (women only, 2.02[1.38,2.96]) of work. Conclusions Employment characteristics of contemporary older workers differ by sex. Job satisfaction and perceived ability to cope with the physical and mental demands of work are key determinants of HRJL which employers could potentially influence to enable work to older ages.
Impact of HLA compatibility in recipients of kidneys from expanded criteria donors: A Collaborative Transplant Study Report

Due to a widespread organ shortage, the use of expanded criteria donors (ECDs) in kidney transplantation has increased persistently, reaching approximately 40% in recent years. Whether human leucocyte antigen (HLA) matching between donor and recipient should be part of allocation algorithms in transplantation of ECD kidneys, and especially of ECD kidneys from ≥70‐year‐old donors, is still in question. To this end, 135,529 kidney transplantations performed between 2000 and 2017 and reported to the Collaborative Transplant Study were analysed and the impact of HLA‐A+B+DR mismatches on death‐censored graft and patient survival as well as on rejection episodes was investigated. Results were stratified according to donor status (standard criteria donor (SCD) versus ECD) and age of ECD. HLA incompatibility increased the five‐year death‐censored graft failure risk similarly strong in recipients of ECD and SCD transplants (hazard ratio (HR) per HLA mismatch 1.078 and 1.075, respectively; p < . 001 for both). Its impact on rejection treatments during the first post‐transplant year was also significant but slightly weaker for recipients of ECD transplants (risk ratio (RR) per HLA mismatch 1.10 for ECD transplants and 1.13 for SCD transplants; p < . 001 for both). Mortality increased gradually from zero to six HLA mismatches in recipients of SCD transplants, whereas for ECD transplants a significant increase was notable only from zero to more than zero mismatches. A significant but slightly less pronounced impact of HLA incompatibility on graft failure was observed in transplants from ≥70‐ compared with <70‐year‐old ECDs (HR per mismatch 1.047 and 1.093; p = .009 and < 0.001, respectively). The influence of HLA mismatches on rejection treatments was the same for both ECD age groups (RR = 1.10, p < .001 and p = .004, respectively). Our data indicate that HLA matching should be part of allocation algorithms not only in transplantation of kidneys from SCDs but also from ECDs.
Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone Receptors

Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating hormone receptors (FSHRs) is essential for the successful reproduction of human beings. Both receptors and the thyroid-stimulating hormone receptor are members of a subset of G-protein coupled receptors (GPCRs) described as the glycoprotein hormone receptors. Their ligands, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and a structurally related hormone produced in pregnancy, human chorionic gonadotropin (hCG), are large protein hormones that are extensively glycosylated. Although the primary physiologic functions of these receptors are in ovarian function and maintenance of pregnancy in human females and spermatogenesis in males, there are reports of LHRs or FSHRs involvement in disease processes both in the reproductive system and elsewhere. In this review, we evaluate the aggregation state of the structure of actively signaling LHRs or FSHRs, their functions in reproduction as well as summarizing disease processes related to receptor mutations affecting receptor function or expression in reproductive and non-reproductive tissues. We will also present novel strategies for either increasing or reducing the activity of LHRs signaling. Such approaches to modify signaling by glycoprotein receptors may prove advantageous in treating diseases relating to LHRs or FSHRs function in addition to furthering the identification of new strategies for modulating GPCR signaling.
Effects of Supplementary Silicon on Nitrogen, Phosphorus and Potassium Contents in the Shoots of Medicago sativa Plants and in the Soil Under Different Soil Moisture Conditions

A pot experiment was carried out to determine the effect of supplementary silicon on nitrogen,phosphorus and potassium contents in the shoots of alfalfa(Medicago sativa) plants and in the soil under different soil moisture conditions.The results indicated that supplementary silicon had no effect on the biomass of alfalfa plants when the soil moisture was 35% or 80% of field water capacity but significantly increased the biomass of alfalfa plants when the soil moisture was 50% or 65% of field water capacity(P0.05). Although supplementary silicon did not affect the total nitrogen content in the shoots of alfalfa plants,it significantly increased the total potassium and phosphorus contents in the shoots of the plants(P0.05). Supplementary silicon had no effect on the total nitrogen,available nitrogen,total phosphorus and total potassium of the soil,however,it significantly increased the available phosphorus content and decreased the available potassium content in the soil(P0.05). This study suggested that supplementary silicon increased the deposit of phosphorus and potassium in alfalfa shoots,benefited the release of available phosphorus and reduced the available potassium content in the soil.
A Robust Dynamic Classifier Selection Approach for Hyperspectral Images with Imprecise Label Information

Supervised hyperspectral image (HSI) classification relies on accurate label information. However, it is not always possible to collect perfectly accurate labels for training samples. This motivates the development of classifiers that are sufficiently robust to some reasonable amounts of errors in data labels. Despite the growing importance of this aspect, it has not been sufficiently studied in the literature yet. In this paper, we analyze the effect of erroneous sample labels on probability distributions of the principal components of HSIs, and provide in this way a statistical analysis of the resulting uncertainty in classifiers. Building on the theory of imprecise probabilities, we develop a novel robust dynamic classifier selection (R-DCS) model for data classification with erroneous labels. Particularly, spectral and spatial features are extracted from HSIs to construct two individual classifiers for the dynamic selection, respectively. The proposed R-DCS model is based on the robustness of the classifiers’ predictions: the extent to which a classifier can be altered without changing its prediction. We provide three possible selection strategies for the proposed model with different computational complexities and apply them on three benchmark data sets. Experimental results demonstrate that the proposed model outperforms the individual classifiers it selects from and is more robust to errors in labels compared to widely adopted approaches.
Changes of vaginal microbiota during cervical carcinogenesis in women with human papillomavirus infection

Objective To evaluate the changes of vaginal microbiota during cervical carcinogenesis in women with high-risk human papillomavirus infection. Materials and methods Vaginal microbiota was analyzed using next-generation sequencing in women with normal, cervical intraepithelial neoplasia (CIN), or cervical cancer. Results A marked decrease of Lactobacillus crispatus was found in the CIN/cancer groups compared with that in the normal group. The diversity of microorganisms increased in patients with CIN or cervical cancer with HPV infection. Atopobium vaginae (OR 4.33, 95% CI 1.15–16.32), Dialister invisus (OR 4.89, 95% CI 1.20–19.94), Finegoldia magna (OR 6.00, 95% CI 1.08–33.27), Gardnerella vaginalis (OR 7.43, 95% CI 1.78–31.04), Prevotella buccalis (OR 11.00, 95% CI 2.00–60.57), and Prevotella timonensis (OR 6.00, 95% CI 1.46–24.69) were significantly associated with the risk of CIN 2/3 or cervical cancer. Conclusion Women with the CIN and cervical cancer showed a high diversity in vaginal microbiota. Depletion of Lactobacillus crispatus and increased abundance of anaerobic bacteria were detected in women with cervical disease.
Muscle activation with swinging loads in bench press

The aim of the study was to compare the EMG amplitude in bench press (stable loads) to bench press using loads moving in anteroposterior and mediolateral directions. Seventeen resistance-trained men, with 9.4±4.7 years of resistance training experience were recruited. After a familiarization session assessing 1 repetition maximum (RM) in the bench press, participants performed: 1) bench press with traditional stable loading 2) bench press with loads (2x5kg) attached as pendulums swinging forward/backwards and 3) left/right in randomized order. The total load was 70% of the 1RM load. Electromyography was measured in the pectoralis major, anterior- and posterior deltoid, biceps brachii, triceps brachii and external obliques. Using stable loads, the pectoralis major demonstrated lower EMG amplitude compared to the two unstable conditions. In the external obliques, the stable conditions demonstrated lower EMG amplitude than the swing in the mediolateral direction, but not the anteroposterior direction. There were no differences between two swinging loads or the three conditions for the triceps brachii, biceps brachii, anterior deltoid or posterior deltoid. In conclusion, swinging in bench press resulted in similar EMG amplitude in the shoulder- and arm muscles, but greater pectoralis and external oblique (only mediolateral swing) activity compared to bench press.
Arrhythmia in Cardiac Sarcoidosis.

Cardiac sarcoidosis (CS) is a complex disease that can manifest as a diverse array of arrhythmias. CS patients may be at higher risk for sudden cardiac death (SCD), and in some cases, SCD may be the first presenting symptom of the underlying disease. As such, identification, risk stratification, and management of CS-related arrhythmia are crucial in the care of these patients. Left untreated, CS carries significant arrhythmogenic morbidity and mortality. Cardiac manifestations of CS are a consequence of an inflammatory process resulting in the myocardial deposition of non-caseating granulomas. Endomyocardial biopsy remains the gold standard for diagnosis, however, biopsy yield is limited by the patchy distribution of the granulomas. As such, recent guidelines have improved clinical diagnostic pathways relying on advanced cardiac imaging to help in the diagnosis of CS. To date, corticosteroids are the best studied agent to treat CS, but are associated with significant risks and limited benefit. Implantable cardioverter defibrillators have an important role in SCD risk reduction. Catheter ablation in conjunction with antiarrhythmics seems to reduce ventricular arrhythmia burden. However, the appropriate selection of these patients is crucial as ablation is likely more helpful in the setting of a myocardial scar substrate versus arrhythmia driven by active inflammation. Further studies investigating CS pathophysiology, the pathway to diagnosis, arrhythmogenic manifestations, and SCD risk stratification will be crucial to reduce the high morbidity and mortality of this disease.