Miracle-dz/UniFAR-FTUs huggingface dataset:
Macrozoobenthic response to fishery: trophic interactions in a highly dynamic coastal ecosystem

Macrobenthic infaunal sampling campaigns that aim at unpreserved “fresh” animals for late biochemical analysis follow one of two strategies: either samples are sieved and sorted o board and individual specimens are frozen, or grab/corer samples are frozen completely an animals are separated from sediments later in the laboratory. This study demonstrates th deep freezing of complete grab samples causes a significant bias in stable isotope ratios o nitrogen (N/N or δN vs. AIR) and carbon (C/C or δC vs. PDB) as well as in the C/ ratio of nine infaunal species from the Germ b destruction and subsequent lo We recommend to abstain from using bulk frozen grab samples for the analysis of C/N rat or stable isotope ratios.
Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses#_#x2014;The representatives of genus Hartmanivirus, family Arenaviridae

The family Arenaviridae comprises three genera, Mammarenavirus, Reptarenavirus and the most recently added Hartmanivirus. Arenaviruses have a bisegmented genome with ambisense coding strategy. For mammarenaviruses and reptarenaviruses the L segment encodes the Z protein (ZP) and the RNA-dependent RNA polymerase, and the S segment encodes the glycoprotein precursor and the nucleoprotein. Herein we report the full length genome and characterization of Haartman Institute snake virus-1 (HISV-1), the putative type species of hartmaniviruses. The L segment of HISV-1 lacks an open-reading frame for ZP, and our analysis of purified HISV-1 particles by SDS-PAGE and electron microscopy further support the lack of ZP. Since we originally identified HISV-1 in co-infection with a reptarenavirus, one could hypothesize that co-infecting reptarenavirus provides the ZP to complement HISV-1. However, we observed that co-infection does not markedly affect the amount of hartmanivirus or reptarenavirus RNA released from infected cells in vitro, indicating that HISV-1 does not benefit from reptarenavirus ZP. Furthermore, we succeeded in generating a pure HISV-1 isolate showing the virus to replicate without ZP. Immunofluorescence and ultrastructural studies demonstrate that, unlike reptarenaviruses, HISV-1 does not produce the intracellular inclusion bodies typical for the reptarenavirus-induced boid inclusion body disease (BIBD). While we observed HISV-1 to be slightly cytopathic for cultured boid cells, the histological and immunohistological investigation of HISV-positive snakes showed no evidence of a pathological effect. The histological analyses also revealed that hartmaniviruses, unlike reptarenaviruses, have a limited tissue tropism. By nucleic acid sequencing, de novo genome assembly, and phylogenetic analyses we identified additional four hartmanivirus species. Finally, we screened 71 individuals from a collection of snakes with BIBD by RT-PCR and found 44 to carry hartmaniviruses. These findings suggest that PLOS Pathogens | https://doi.org/10.1371/journal.ppat. 1007415 November 14, 2018 1 / 29 a1111111111 a1111111111 a1111111111 a1111111111 a1111111111
Diet, nutrition and haematology of dasyurid marsupials

Stannard's PhD thesis examined diet, nutrition and haematology of six dasyurid species, which are a family of insectivorous and/or carnivorous Australian marsupials. Diet and nutrition were studied to obtain information on diet choice by translocated animals and food digestibility in captive animals. Haematology was studied in captivity as it is associated with clinical health and influenced by nutrition. The broad aim of the study was to aid current wildlife management practices and future conservation efforts (such as reintroduction and translocation programs) for these six species and other marsupial species in Australia.
The cientific WorldJOURNAL Clinical Study Central Precocious Puberty : Treatment with Triptorelin 11 . 25 mg

1 Adolescent Medicine, I Pediatric Division, Department of Obstetrics, Gynecology and Pediatrics, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy 2 Department of Gynecology, Obstetrics and Pediatrics, University of Bologna, 40138 Bologna, Italy 3 Department of Pediatrics, University of Messina, 98124 Messina, Italy 4 Department of Paediatrics, University of Florence, 50100 Florence, Italy 5 Paediatric Endocrinology, Regina Margherita Children’s Hospital, 10126 Turin, Italy 6 Endocrinology Unit, Department University-Hospital, Bambino Gesù Children’s Hospital, Tor Vergata University, 00165 Rome, Italy 7 Pediatric and Adolescent Endocrinology, Department of Pediatrics, San Raffaele Scientific Institute, Vita-Salute S. Raffaele University, 20132 Milan, Italy
Annual Research Briefs

This report contains the 1997 annual progress reports of the research fellows and students supported by the Center for Turbulence Research (CTR). Titles include: Invariant modeling in large-eddy simulation of turbulence; Validation of large-eddy simulation in a plain asymmetric diffuser; Progress in large-eddy simulation of trailing-edge turbulence and aeronautics; Resolution requirements in large-eddy simulations of shear flows; A general theory of discrete filtering for LES in complex geometry; On the use of discrete filters for large eddy simulation; Wall models in large eddy simulation of separated flow; Perspectives for ensemble average LES; Anisotropic grid-based formulas for subgrid-scale models; Some modeling requirements for wall models in large eddy simulation; Numerical simulation of 3D turbulent boundary layers using the V2F model; Accurate modeling of impinging jet heat transfer; Application of turbulence models to high-lift airfoils; Advances in structure-based turbulence modeling; Incorporating realistic chemistry into direct numerical simulations of turbulent non-premixed combustion; Effects of small-scale structure on turbulent mixing; Turbulent premixed combustion in the laminar flamelet and the thin reaction zone regime; Large eddy simulation of combustion instabilities in turbulent premixed burners; On the generation of vorticity at a free-surface; Active control of turbulent channel flow; A generalized framework for robust control in fluid mechanics; Combined immersed-boundary/B-spline methods for simulations of flow in complex geometries; and DNS of shock boundary-layer interaction - preliminary results for compression ramp flow.
Intraoperative indocyanine green fluorescence imaging in breast surgery

Background Since postoperative complications after reconstructive breast surgery are often related to drastic increases of patient suffering and treatment costs, several devices were developed in order to avoid them. In this respect, the intraoperative fluorescence angiography with indocyanine green (ICG) provides promising results by detecting ischemic skin intraoperatively. Methods Women who underwent reconstructive breast surgery at the breast center at Charité between April and December 2017 were included in the analysis. General patient characteristics, medical history, type of surgery, as well as postoperative parameters, complications and patient reported outcomes were compared between patients operated using ICG fluorescence angiography and conventionally operated patients. Results Among 68 patients with breast reconstruction 36 (52.9%) were operated with the ICG angiography device and 32 (47.1%) without. No significant differences regarding patient demographics, medical history, and surgical procedure were found. Wound healing disorders occurred in 11.1% of the ICG group and in 9.4% of the control group. About 11% of both groups developed major complications which required revision surgery. Complication rates and patient reported outcome did not differ significantly. Across both groups, only the risk factor resection weight (≥ 500 g) was significantly associated with wound healing disorders (RR = 6.80; 95%CI 1.93–23.81; p = 0.022). Conclusion The purchase of a device for intraoperative ICG angiography might not be reasonable for every breast center. Further research in a larger cohort and prospective manner should be done to determine if the addition of ICG to breast reconstructive surgery in the German setting really leads to improved patient care.
Induction of Interferon-Stimulated Genes and Cellular Stress Pathways by Morpholinos

The phenotypes caused by morpholino-mediated interference of gene function in zebrafish are often not observed in the corresponding mutant(s). We took advantage of the availability of a relatively large collection of transcriptomic datasets to identify common signatures that characterize morpholino-injected animals (morphants). In addition to the previously reported activation of tp53 expression, we observed increased expression of the interferon-stimulated genes (ISGs), isg15 and isg20, an extrinsic cell death pathway gene, casp8, and other cellular stress response genes including phlda3, mdm2 and gadd45aa. Studies involving segmentation stage embryos were more likely to show upregulation of these genes. We also found that these genes could be upregulated by an increasing dose of egfl7 morpholino, or high doses of standard control morpholino. Thus, these data suggest that morpholinos can stimulate the innate immune response in zebrafish, as was recently reported in Xenopus.
A Pan-Amazonian species delimitation: high species diversity within the genus [i]Amazophrynella[i] (Anura: Bufonidae)

1 Laboratory of Evolution and Animal Genetics, Department of Genetics, ICB, Universidade Federal do Amazonas, Brazil 2 Laboratoire Ecologie, Evolution et Interactions des Systèmes Amazoniens, Centre de recherche de Montabo, Cayenne, French Guiana 3 Museo de Zoología, Escuela de Biología, Pontificia Universidad Católica del Ecuador, Quito, Ecuador 4 Laboratório de Zoologia, Faculdade de Ciências Biológicas, Campus Universitário de Altamira, Universidade Federal do Pará, Altamira, Para, Brazil 5 Departamento de Vertebrados, Museu Nacional, Rio de Janeiro, Rio de Janeiro, Brazil 6 Coleccion de anfibios y reptiles, Museo de la Biodiversidad, Cusco, Peru 7 Museo de Historia Natural, Universidad Nacional de San Antonio Abad, Cusco, Peru 8 CEQUA, Coordenação de Biodiversidade, Instituto Nacional de Pesquisas da Amazônia, Manaus, Amazonas, Brazil 9 Laboratory of Evolution and Animal Genetics, Department of Genetics, ICB, Universidade Federal do Amazonas, Manaus, Amazonas, Brazil 10 Departamento de Ciências Biológicas, Centro de Ciências Biológicas e da Saúde, Universidade Regional do Cariri, Crato, Ceara, Brazil 11 Museu Paraense Emilio Goeldi, Belem, Para, Brazil 12 Departamento de Biologia, ICB, Universidade Federal do Amazonas, Manaus, Amazonas, Brazil
identifying predictive clinical characteristics of the treatment efficacy of mirtazapine monotherapy for major depressive disorder

Background: Mirtazapine, which is classified as a noradrenergic and specific serotonergic antidepressant, is widely prescribed for the treatment of major depressive disorder. The potential predictive factors of the efficacy of mirtazapine and the tolerability based on the incidence of oversedation and jitteriness/anxiety syndrome were evaluated. Patients and methods: Patients with major depressive disorder were retrospectively investigated. Study subjects comprised 68 patients with depression who received mirtazapine as an initial antidepressant at the Department of Psychiatry of the Tokyo Women’s Medical University Hospital from September 2009 to March 2013. The efficacy of mirtazapine monotherapy was evaluated based on the Clinical Global Impression Improvement score. Clinical characteristics were compared between remission and nonremission groups to determine the factors predicting the efficacy. Moreover, discontinuation rates due to adverse effects, including oversedation and jitteriness/anxiety syndrome, were examined, and the effects of confounding factors were evaluated. Results: The remission rate of mirtazapine monotherapy was 36.8% among the 68 enrolled subjects. The mean final doses in the remission and nonremission groups were 27.6 ± 13.5 mg and 26.0 ± 14.1 mg, respectively, and there was no significant difference between them. Multiple logistic analyses revealed that the absence of guilt (odds ratio [OR] = 0.15; 95% CI [1.66–37.24], P = 0.006) and the presence of psychomotor retardation (OR = 4.30; 95% CI [1.30–16.60], P = 0.016) were significantly related to the efficacy of mirtazapine monotherapy. The discontinuation rates due to oversedation and jitteriness/anxiety syndrome were 13.2% and 11.8%, respectively. Age did not differ significantly between patients with or without oversedation or jitteriness/anxiety syndrome ( P = 0.078 and P = 0.579, respectively). Conclusion: The absence of guilt and the presence of psychomotor retardation may predict the efficacy of mirtazapine, and mirtazapine may be tolerable for all ages.
Ocular hypertension and hypotony as determinates of outcomes in uveitis

Purpose: To assess ocular hypertension (OHT) and hypotony as outcomes of uveitis in patients managed in a mid-Atlantic tertiary care center. Methods: Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. Results: A total of 442 patients (582 eyes) with uveitis were identified and included in the study. The patient population was 57.0% female. Overall, 61.9% were Caucasian and 26.6% were African American. Mean age was 46.8 years. Overall, 11.5% of the eyes had OHT at initial visit, and 7.9% had OHT at final visit ( P = 0.035). For each additional decade of life, the odds that an eye had OHT were elevated by a factor of 1.15 (95% confidence interval [CI]: [1.02, 1.30], P = 0.027) at initial visit and by a factor of 1.15 (95% CI: [1.00, 1.32], P = 0.055) at final visit. The odds that an anterior uveitis eye had OHT were greater by a factor of 2.50 (95% CI: [1.22, 5.14], P = 0.013) than the odds for a nonanterior uveitis eye at initial visit and greater by a factor of 2.61 (95% CI: [1.24, 5.50], P = 0.011) at final visit. For each additional 0.5 logarithm of the minimum angle of resolution increase in initial visual acuity, the odds that an affected eye had OHT were elevated by a factor of 1.18 (95% CI: [1.00, 1.39], P = 0.047) at initial visit and 1.23 (95% CI: [0.99, 1.54], P = 0.065) at final visit. Overall, 21 of 582 eyes (3.6%) were hypotonous initially, while 24 of 582 eyes (4.1%) were hypotonous at final follow-up ( P = 0.631). Conclusion: OHT was associated with increasing age, anterior uveitis, and poor presenting visual acuity. Ocular hypotony was more common in anterior uveitis than in nonanterior uveitis. Fluctuations in intraocular pressure are an important cause of visual impairment in patients with uveitis. Careful monitoring of all uveitis patients, and especially those most at risk for fluctuations in intraocular pressure, can preserve vision and improve patient outcomes. Optometry; Visual science; Pharmacology and drug therapy in eye diseases; Basic Sciences; Primary and Secondary eye care; Patient and Quality of
Aerial surveys for sea turtles in North Carolina inshore waters

Recent studies have demonstrated the importance ofinshore waters as developmental and foraging habi­ tats for threatened and endangered sea turtles along the Atlantic Coast of the United States (e.g. Medonca and Ehrhart, 1982; Ehrhart, 1983; Lutcavage and Musick, 1985; Kein­ ath et aI., 1987; Burke et aI., 1992, 1993). A study of sea turtles in North Carolina waters used sight­ ings reported by the public and documented the importance of Pamlico and Core Sounds for imma­ ture loggerhead, Caretta caretta; green, Cheloniamydas;and Kemp's ridley, Lepidochelys kempii, sea turtles (Epperly et aI., in press, a). As part of the same study, aerial surveys were employed over a 3-yr period to provide independent quan­ titative verification of the impor­ tance of Pamlico and Core Sounds as sea turtle habitats. We report the results ofthe aerial survey work in Pamlico and Core Sounds, part of the largest estua­ rine system in the southeast United States. Once aerial survey method­ ology was validated in inshore wa­ ters, our goals were 1) to obtain in­ dependent evidence for the season­ ality and distribution patterns of turtles obtained from other sources, 2) to quantify the abundance ofsea turtles in the sounds and compare those densities with other areas, and 3) to evaluate the consequences of the application of line vs. strip survey methodology to the data.
is there any superiority among diagnostic methods in organizing pneumonia in terms of clinical features of the patients?

Background: Organizing pneumonia (OP) can be idiopathic or secondary to some clinical situations. If an etiological cause is not present, this phenomenon is called cryptogenic OP. Secondary OP is associated with various diseases that are known to induce the OP. Objectives: The aim of this study was to evaluate the clinical features of the cases with OP and compare the patients diagnosed by bronchoscopic transbronchial biopsy with patients diagnosed by surgical lung biopsy. Patients and methods: Medical records of 41 patients diagnosed with OP between 2004 and 2014 were reviewed retrospectively. Results: Totally, 41 patients with OP were identified. In all, 39.02% of the cases were diagnosed by bronchoscopic methods, and 60.97% of the cases were diagnosed by surgical procedures. Although the frequency of ground glass opacities, consolidations, and micronodules was higher in the group diagnosed by bronchoscopy, mass-like lesions were more common in the cases diagnosed by surgery. Bronchoscopy, performed in 30 patients totally, had a diagnostic efficacy of 53.33%. Diagnostic value of bronchoscopy was significantly higher in cryptogenic OPs. Although diffuse radiological pattern was more common in “successful bronchoscopy” group, frequency of focal pattern was higher in “failed bronchoscopy” group. Ground glass opacity in successful bronchoscopy group and mass-like lesions in failed bronchoscopy group reached significant differences. Conclusion: There were significant differences between the diagnostic procedures in terms of radiological patterns. This is the first study about the relationship between the diagnostic methods and the characteristics of OP.
Filling and emptying cycles for stormwater storage tanks in separated systems

This paper investigates how the annual runoff depth intercepted by urban stormwater on-line storage tanks is influenced by their running rules, their specific capacity per impervious catchment area, the depression storage on the catchment surfaces and the minimum inter event time. But, surprisingly, the three different real rainfall series considered in the numerical tests seem to yield quite similar outcomes. In addition, the Gaussian probability distribution is found to be a good fitting of the annual intercepted runoff depths, allowing an easy forecast of their quantiles for a given probability of non-exceedence (or probability of exceedence). For practical aims, this is a very interesting piece of information for the runners of wastewater treatment plants who are supposed to be in charge of dealing, after rainfall events, with the first foul flush volumes intercepted and stored into the urban stormwater tanks.
Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn

Objectives: To assess the effectiveness of high dose intravenous immunoglobulin (HDIVIG) in reducing the need for exchange transfusion in neonates with proven haemolytic disease due to Rh and/or ABO incompatibility. To assess the effectiveness of HDIVIG in reducing the duration of phototherapy and hospital stay. Design: Systematic review of randomised and quasi-randomised controlled trials comparing HDIVIG and phototherapy with phototherapy alone in neonates with Rh and/or ABO incompatibility. Results: Significantly fewer infants required exchange transfusion in the HDIVIG group (relative risk (RR) 0.28 (95% confidence interval (CI) 0.17 to 0.47); number needed to treat 2.7 (95% CI 2.0 to 3.8)). Also hospital stay and duration of phototherapy were significantly reduced. Conclusion: HDIVIG is an effective treatment.
Multi-objective Feature Attribution Explanation For Explainable Machine Learning

The feature attribution-based explanation (FAE) methods, which indicate how much each input feature contributes to the model’s output for a given data point, are one of the most popular categories of explainable machine learning techniques. Although various metrics have been proposed to evaluate the explanation quality, no single metric could capture different aspects of the explanations. Different conclusions might be drawn using different metrics. Moreover, during the processes of generating explanations, existing FAE methods either do not consider any evaluation metric or only consider the faithfulness of the explanation, failing to consider multiple metrics simultaneously. To address this issue, we formulate the problem of creating FAE explainable models as a multi-objective learning problem that considers multiple explanation quality metrics simultaneously. We first reveal conflicts between various explanation quality metrics, including faithfulness, sensitivity, and complexity. Then, we define the considered multi-objective explanation problem and propose a multi-objective feature attribution explanation (MOFAE) framework to address this newly defined problem. Subsequently, we instantiate the framework by simultaneously considering the explanation’s faithfulness, sensitivity, and complexity. Experimental results comparing with six state-of-the-art FAE methods on eight datasets demonstrate that our method can optimize multiple conflicting metrics simultaneously and can provide explanations with higher faithfulness, lower sensitivity, and lower complexity than the compared methods. Moreover, the results have shown that our method has better diversity, i.e., it provides various explanations that achieve different trade-offs between multiple conflicting explanation quality metrics. Therefore, it can provide tailored explanations to different stakeholders based on their specific requirements.
Alleviating Video-length Effect for Micro-video Recommendation

Micro-video platforms such as TikTok are extremely popular nowadays. One important feature is that users no longer select interested videos from a set; instead, they either watch the recommended video or skip to the next one. As a result, the time length of users’ watching behavior becomes the most important signal for identifying preferences. However, our empirical data analysis has shown a video-length effect that long videos can more easily receive a higher value of average view time, and thus adopting such view-time labels for measuring user preferences can easily induce a biased model that favors the longer videos. In this article, we propose a Video Length Debiasing Recommendation (VLDRec) method to alleviate such an effect for micro-video recommendation. VLDRec designs the data labeling approach and the sample generation module that better capture user preferences in a view-time-oriented manner. It further leverages the multi-task learning technique to jointly optimize the above samples with the original biased ones. Extensive experiments show that VLDRec can improve users’ view time by 1.81% and 11.32% on two real-world datasets, given a recommendation list of a fixed overall video length, compared with the best baseline method. Moreover, VLDRec is also more effective in matching users’ interests in terms of the video content.