Miracle-dz/UniFAR-FTUs huggingface dataset:
INFLUENCE OF BRANCHED-CHAIN AMINO ACID SUPPLEMENTATION ON GROWING MOUNTAIN RABBIT'S PRODUCTIVE PERFORMANCE

SUMMARY he objective of this study was to measure the productive performance of growing rabbits as influenced by the two different level of dietary protein under three levels of branched-chain amino acids (BCAAs) supplementations. A 90-day feeding trial was conducted. A total rabbits were 72 at the age of 8 weeks were weighed when rabbits arrival at the farm and randomly distributed to six experimental groups. (G1): rabbits fed control diet contain recommended protein level (18% CP) without any supplementation. (G2 and G3): rabbits fed control diet contain recommended protein (18% CP) supplemented with 2 g BCAAs/kg diet 2:1:1 and with 2 g BCAA/kg diet 3:1:2 (luecine: Iso luecine: Valine). (G4): rabbits fed control diet contain low protein level (17% CP) without any supplementation. (G5 and G6): rabbits fed control diet contain low protein (17% CP) supplemented with 2 g BCAAs/kg diet 2:1:1 and 2 g BCAAs/kg diet 3:1:2 (luecine: Iso luecine: Valine). Group rabbits fed (G3) achieved the highest significantly (P<0.05) DM, OM, CP, EE and NFE digestion coefficients. Also, nutritive values in term of DCP and TDN, followed them group fed (G2) and followed by (G6), (G1) then group fed (G5). Rabbits group fed (G3) achieved significantly the highest final LBW, total gain, and daily gain, followed them in the values the group fed recommended dietary protein (G2) and (G6), which did not show any significant differences between them in the final body weight of rabbits, Group fed (G3) recorded the best feed conversion ratio compared to the other groups. rabbits fed recommended protein (G3) achieved The highest significantly (P<0.05) carcass weight values, followed them in the values of the group fed recommended protein (G2) and (G6), rabbits fed (G6) achieved the highest significantly (P<0.05) Arginine, Isoleucine, Histidine, Leucine, threonine, , phenylalanine, Valine and tryptophan values, followed them in the values of the group fed (G2) and (G6), Rabbits fed (G1) and (G4) achieved the highest significantly (P<0.05) TVN and TBA values, rabbits fed (G3) achieved The highest significantly (P<0.05) antioxidant activity presented in GPx, SOD and CAT (U/mg protein) values, followed them in the values the group fed (G2) and low protein (G6), While the lowest values were significantly recorded for the 18% and 17% groups at 0g BCAA level for oxidative activity. Rabbits fed (G3) achieved the highest significantly (P<0.05) T.P globulin, albumin, creatinine, urea, AST and ALT, Also, immunity values in term of IgG and IgM. And the highest relative economic efficiency recorded by (G6 and G3). Overall, Group 3 recorded the best results obtained, while Group 3 and 6 recorded the best results in economic efficiency calculations.
Financial Mismanagement of Small Businesses: A Study Based on the Hotel Industry in Nuwara Eliya District

The purpose of the study was to identify the financial mismanagement of small businesses and their effect on the business’s success. This research used the qualitative approach and continued the study through the general qualitative method. Sample were selected based on the purposive sampling method. Accordingly, data collection was done through in-depth interviews with owners of six small businesses in the Talawakele - Lidula Municipal Council area in the Nuwara Eliya District. The data were analysed, and themes were derived using thematic analysis. The main mismanagement identified from the study was mismanaging start-up capital, cash flows, budgetary system, personal spending, retained earnings, and working capital. Due to these mismanagements, businesses cannot run with a proper plan. The findings of this study will enable small businesses to identify their financial mismanagement. These findings will also help policymakers to identify the areas that are required to improve the financial management literacy of small business owners.
Unified Communications Technology: The Considerations for Adoption for Administration and Pedagogy

We are in a different place, where today’s learners require educators to broaden their methods of pedagogy in order to interact more effectively with digital-native learners (Dietz, 2010). Educators need a less structured and more informal learning setting that leverages already established teaching tools supporting a constructivist learning environment (Dietz, 2010). In addition, institutions need to leverage these technologies with their business processes in order to provide for greater efficiencies and collaboration (Herrell, 2011). In support of these findings, The College of Staten Island (CSI) has researched unified communications (UC) technology that uses a unified learning environment. This comprehensive solution will be used to replace a life-cycled phone system, as well as enhance administrative processes and pedagogical applications. This paper will discuss the technology status at CSI, options in support of a UC environment, and alternative technologies that provide similar functionality. Challenges and opportunities associated with a UC environment will be addressed, as well as how this environment can respond to individual learning styles when teaching to a diverse student population. As part of this decision of implementing a UC system, one must consider whether it is worth the resources to implement this technology or whether disparate systems with the same functionality will suffice. This paper will address that question by describing the strategy CSI is following in order to move towards the successful adoption of a UC environment in both administrative and pedagogical applications.
Metabolic Response of Peach Fruit to Invasive Brown Marmorated Stink Bug (Halyomorpha halys Stål.)’s Infestation

The brown marmorated stink bug (BMSB; Halyomorpha halys Stål.) is a highly destructive and polyphagous invasive pest that poses a serious threat to more than a hundred reported host plants. In the current study, the metabolic response of peach fruit of two cultivars—‘Maria Marta’ and ‘Redhaven’—to BMSB infestation was studied using high-performance liquid chromatography (HPLC) and mass spectrometry (MS). In general, a strong phenolic response to BMSB infestation in peach flesh in the injury zone was observed, with flavanol content increasing by 2.4-fold, hydroxycinnamic acid content by 5.0-fold, flavonol content by 3.2-fold, flavanone content by 11.3-fold, and dihydrochalcones content by 3.2-fold compared with the undamaged tissue in the cultivar ‘Maria Marta’. The phenolic response in the ‘Redhaven’ cultivar was even stronger. Consequently, the total phenolic content in the injured flesh also increased, 3.3-fold in ‘Maria Marta’ and 6.9-fold in ‘Redhaven’, compared with the uninjured flesh. Infestation with BMSB induced the synthesis of cyanidin-3-glucoside, which is not normally present in peach flesh. In comparison, the phenolic response was lower in peach peel, especially in the cultivar ‘Maria Marta’. The study showed that both peach cultivars reacted to BMSB infestation with an increase in phenolic content in the peach flesh, but in a limited area of injury.
Measuring Preferences on Environmental Damages in LCIA

Goal, Scope and Background The weighting of environmental impacts and damages on the safeguard subjects Human Health, Ecosystems, and Resources is a significant step of full aggregated LCIA. Panel surveys have become a common approach in LCIA research to investigate the preferences of stakeholders on environmental impacts and damages. Despite the numerous studies, the knowledge on how to elicit reliable weights is still poor and inconsistent. We present a questionnaire study with 58 environmental science students to investigate so-called framing effects in panel surveys. Main Features. The study investigates the significance of different framings, which were provided by three references. In addition, the significance of quantitative information provided in the questionnaire is tested. The references are (a1) safeguard subjects without specified additional information, (a2) damages in Europe as they are perceived by the panelist, and (a3) quantified scenarios derived from Eco-indicator99. All participants ranked and rated the importance of the safeguard subjects three times, once within each reference system. According to a testof-scope study, quantitative information given to the panelist was varied. One level (b1) included data from the Ecoindicator99 methodology, whereas the other group (b2) received data with significantly higher Human Health damages and lower Ecosystem damages, ceteris paribus. This design allows testing the influence of quantitative data on the rating. Results. The weighting of the safeguard subjects (a1) reveals that Human Health is considered a slightly more important safeguard subject than Ecosystems. However, both are judged to be significantly more important than Resources. This picture changes for the references (a2) and (a3) where damages were weighted. For both references, the respondents rated damages to Ecosystems as most important followed by Resources and Human Health, showing by far the lowest weights. Therefore, the framing of the reference that was weighted played a significant role. The ratings of the subgroups (b1) and (b2) did not differ with respect to the importance of damages, though substantially different quantitative information was given.
Dual soluble epoxide hydrolase inhibitor – farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis

Introduction Renal fibrosis associated with inflammation is a critical pathophysiological event in chronic kidney disease (CKD). We have developed DM509 which acts concurrently as a farnesoid X receptor agonist and a soluble epoxide hydrolase inhibitor and investigated DM509 efficacy as an interventional treatment using the unilateral ureteral obstruction (UUO) mouse model. Methods Male mice went through either UUO or sham surgery. Interventional DM509 treatment (10mg/kg/d) was started three days after UUO induction and continued for 7 days. Plasma and kidney tissue were collected at the end of the experimental protocol. Results UUO mice demonstrated marked renal fibrosis with higher kidney hydroxyproline content and collagen positive area. Interventional DM509 treatment reduced hydroxyproline content by 41% and collagen positive area by 65%. Renal inflammation was evident in UUO mice with elevated MCP-1, CD45-positive immune cell positive infiltration, and profibrotic inflammatory gene expression. DM509 treatment reduced renal inflammation in UUO mice. Renal fibrosis in UUO was associated with epithelial-to-mesenchymal transition (EMT) and DM509 treatment reduced EMT. UUO mice also had tubular epithelial barrier injury with increased renal KIM-1, NGAL expression. DM509 reduced tubular injury markers by 25-50% and maintained tubular epithelial integrity in UUO mice. Vascular inflammation was evident in UUO mice with 9 to 20-fold higher ICAM and VCAM gene expression which was reduced by 40-50% with DM509 treatment. Peritubular vascular density was reduced by 35% in UUO mice and DM509 prevented vascular loss. Discussion Interventional treatment with DM509 reduced renal fibrosis and inflammation in UUO mice demonstrating that DM509 is a promising drug that combats renal epithelial and vascular pathological events associated with progression of CKD.
Inter-discharge optimization for fast, reliable access to ASDEX Upgrade advanced tokamak scenario

Rapid inter-discharge simulation and optimization using the RAPTOR code have allowed the development of a reliable and reproducible early heating strategy for an advanced tokamak (AT) scenario on ASDEX Upgrade. Solving for electron heat and current diffusion in RAPTOR with ad-hoc formulas for heat transport and electron cyclotron current drive (ECCD) efficiency is found to robustly recover the coupled dynamics of Te and q, while maintaining model parameters fixed for all discharges. The pedestal top boundary condition in pre-shot simulations is set by a newly derived scaling law for the electron pressure at ρ = 0.8, using a data set of previous AT discharges. RAPTOR simulations have allowed to develop an understanding of the onset of 3/2 tearing modes, which were observed to have a detrimental impact on confinement when low magnetic shear conditions are present at the rational surface during the high-β phase. Delaying the NBI heating, by a specific time interval found via simulations, has led to avoiding these modes. A non-linear optimization scheme has been applied to optimize the ECCD deposition radii to reach a stationary state with qmin>1 at the beginning of the flat-top phase, while ensuring a non-zero magnetic shear at q = 1.5 throughout the high-β phase, and has been successfully tested in experiment. However, further experiments, aiming for qmin>1.5 , have highlighted limitations of the present feedforward control approach in the presence of shot-to-shot variations that are not included in the applied model. Application of real-time model-based control is proposed to overcome model-reality mismatches in future work.
Design Scheme of Signal-to-Noise Ratio for Broadband Generalized Grid Impedance Identification

Under weak grid conditions, the number of oscillation accidents caused by the impedance mismatch between the power grid and the grid-tied inverters is on the rise, which makes the accurate identification of the broadband impedance characteristics of the power grid that can sense the current operating state of the system an urgent problem to be solved. This article theoretically analyzes the discrepancy between the impedance characteristics of the conventional purely inductive grid impedance and the generalized grid impedance by comparing the amplitude-phase characteristic curves of both, which in turn affects the analytical results of stability. Subsequently, in order to accurately recognize the GGI, a signal-to-noise ratio (SNR) design scheme based on the active impedance identification technique is proposed, which investigates the impact of SNR on the identification accuracy from the perspective of a grid-tied inverter, with the GGI including transmission lines and grid-tied devices external to the inverter as the identification target. Moreover, current disturbances at different characteristic harmonic frequency points are injected into the grid in the MATLAB/Simulink platform to verify the accuracy of the SNR design scheme with the help of the sweep results of GGI. Finally, the significance of generalized grid impedance as the main form of the grid is further revealed through comparative experiments on the RT-BOX platform.
The Influence of Leverage, Debt Default, Company Size, and the Previous Year's Audit Opinion on the Acceptance of Going Concern Audit Opinions

This study investigates the factors influencing the acceptance of going concern audit opinions, focusing on leverage, debt default, company size, and the preceding year's audit opinion. The research is based on the financial reports of 38 manufacturing companies listed on the Indonesia Stock Exchange (BEI), spanning a period of 5 years. Employing a purposive sampling method, logistic regression analysis is applied to assess the impact of these variables. The findings for the period 2017-2021 indicate that debt default, company size, and the previous year's audit opinion play a significant role in influencing the acceptance of going concern audit opinions. However, leverage does not exhibit a statistically significant effect on the acceptance of such opinions during this period. Contrastingly, the results for the years 2020-2021 reveal that the previous year's audit opinion is the sole influential factor affecting the acceptance of going-concern audit opinions. Leverage, debt default, and company size do not demonstrate a significant impact on the acceptance of going concern audit opinions during this specific timeframe. This research contributes valuable insights into the dynamics shaping the acceptance of going concern audit opinions, shedding light on the nuanced interplay of financial variables within the context of manufacturing companies listed on the Indonesia Stock Exchange.
Fast 3‐D large‐scale gravity and magnetic modeling using unstructured grids and an adaptive multilevel fast multipole method

A novel fast and accurate algorithm is developed for large‐scale 3‐D gravity and magnetic modeling problems. An unstructured grid discretization is used to approximate sources with arbitrary mass and magnetization distributions. A novel adaptive multilevel fast multipole (AMFM) method is developed to reduce the modeling time. An observation octree is constructed on a set of arbitrarily distributed observation sites, while a source octree is constructed on a source tetrahedral grid. A novel characteristic is the independence between the observation octree and the source octree, which simplifies the implementation of different survey configurations such as airborne and ground surveys. Two synthetic models, a cubic model and a half‐space model with mountain‐valley topography, are tested. As compared to analytical solutions of gravity and magnetic signals, excellent agreements of the solutions verify the accuracy of our AMFM algorithm. Finally, our AMFM method is used to calculate the terrain effect on an airborne gravity data set for a realistic topography model represented by a triangular surface retrieved from a digital elevation model. Using 16 threads, more than 5800 billion interactions between 1,002,001 observation points and 5,839,830 tetrahedral elements are computed in 453.6 s. A traditional first‐order Gaussian quadrature approach requires 3.77 days. Hence, our new AMFM algorithm not only can quickly compute the gravity and magnetic signals for complicated problems but also can substantially accelerate the solution of 3‐D inversion problems.
Propolis Protects GC-1spg Spermatogonial Cells against Tert-Butyl Hydroperoxide-Induced Oxidative Damage

Propolis is a natural resin produced by honeybees with plenty of pharmacologic properties, including antioxidant activity. Oxidative stress disrupts germ cell development and sperm function, with demonstrated harmful effects on male reproduction. Several natural antioxidants have been shown to reduce oxidative damage and increase sperm fertility potential; however, little is known about the effects of propolis. This work evaluated the role of propolis in protecting spermatogonial cells from oxidative damage. Propolis’ phytochemical composition and antioxidant potential were determined, and mouse GC-1spg spermatogonial cells were treated with 0.1–500 µg/mL propolis (12–48 h) in the presence or absence of an oxidant stimulus (tert-butyl hydroperoxide, TBHP, 0.005–3.6 µg/mL, 12 h). Cytotoxicity was assessed by MTT assays and proliferation by Ki-67 immunocytochemistry. Apoptosis, reactive oxygen species (ROS), and antioxidant defenses were evaluated colorimetrically. Propolis presented high phenolic and flavonoid content and moderate antioxidant activity, increasing the viability of GC-1spg cells and counteracting TBHP’s effects on viability and proliferation. Additionally, propolis reduced ROS levels in GC-1spg, regardless of the presence of TBHP. Propolis decreased caspase-3 and increased glutathione peroxidase activity in TBHP-treated GC-1spg cells. The present study shows the protective action of propolis against oxidative damage in spermatogonia, opening the possibility of exploiting its benefits to male fertility.
Low follistatin level is a causal risk factor for spontaneous abortion: a two-sample mendelian randomization study

Background Recurrent pregnancy loss is a distressing event during pregnancy, and understanding its causal factors is crucial. Follistatin, a glycoprotein involved in folliculogenesis and embryogenesis, has been implicated as a potential contributor to the risk of spontaneous abortion. However, establishing a causal relationship requires rigorous investigation using robust methods. Methods In this study, we utilized mendelian randomization (MR), a powerful genetic epidemiological approach, to examine the causal relationship between follistatin levels and spontaneous abortion. We obtained instrumental variables strongly associated with follistatin levels from large-scale genome-wide association from the IEU database. The inverse variance weighting (IVW) method was taken as gold standard. We also performed sensitivity test to evaluate the robustness of our result. Results MR analysis revealed a significant causal relationship between low follistatin levels and spontaneous abortion (p = 0.03). Sensitivity analyses, including pleiotropy test, heterogeneity test, and leave-one-out analysis, all supported the robustness of our findings. Conclusion Our study provides compelling evidence supporting the causal relationship between low follistatin levels and increased risk of spontaneous abortion. These findings underscore the importance of follistatin in the etiology of spontaneous abortion and suggest potential preventive interventions. Modulating follistatin levels or relevant pathways could hold promise for reducing the incidence of spontaneous abortion and improving reproductive outcomes. The utilization of MRs strengthens the validity of our results by mitigating confounding and reverse causality biases. Further research is needed to elucidate the underlying molecular mechanisms and explore therapeutic strategies targeting follistatin levels.
Pengembangan Media Pembelajaran Matematika

This research aims to determine the feasibility of learning media based on multimedia on trigonometry material using Adobe Flash CS 3 Professional application. This research uses with a ADDIE model. Data analysis was done by using quantitive descriptive data analysis. The result of data analysis of validation expert assessment of materials (Lecturer in Mathematics Education Mather Fitri Umardliyah, M.Pd.) there are 4,25 to the category of very valid, validation expert of assessment of materials (Teacher of mathematic Mr. Sumarno, S.Pd.) contained 4,0 with a valid category. While there are 4,3 with media (Lecturer of Technology of Information Mrs. Siti Sufaidah, S.Kom., M.Si.) expert with a very valid category. Meanwhile, the result of students responses contained 84% in very good category. This result indicate that learning media based on multimedia on trigonometry material using Adobe Flash CS 3 Professional application feasible and gets a positive responses from students it means students are enthusiastic in using learning media and learning media based on multimedia on trigonometry material using Adobe Flash CS 3 Professional application can helps the students in receiving the learning materials.
Reconsidering Extinction: Rediscovery of Incilius holdridgei (Anura: Bufonidae) in Costa Rica After 25 Years

JUAN ABARCADepartment of Biology, Universidad Nacional de Costa RicaHeredia, 40101, Heredia, Costa RicaGERARDO CHAVES*Zoology Museum, Department of BiologyUniversidad de Costa Rica, Mercedes de Montes de Oca11503, San Jose, Costa RicaADRIAN GARCIA-RODRIGUEZZoology Museum, Department of BiologyUniversidad de Costa Rica, Mercedes de Montes de Oca11503, San Jose, Costa Ricaand RODOLFO VARGASDepartment of Biology, Universidad Latina de Costa RicaSan Pedro de Montes de Oca, 11501, San Jose, Costa Rica* Corresponding author; e-mail: cachi13@gmail.com
Maternal Influenza and Offspring Neurodevelopment

This review examines the complex interactions between maternal influenza infection, the immune system, and the neurodevelopment of the offspring. It highlights the importance of high-quality studies to clarify the association between maternal exposure to the virus and neuropsychiatric disorders in the offspring. Additionally, it emphasizes that the development of accurate animal models is vital for studying the impact of infectious diseases during pregnancy and identifying potential therapeutic targets. By drawing attention to the complex nature of these interactions, this review underscores the need for ongoing research to improve the understanding and outcomes for pregnant women and their offspring.