Miracle-dz/UniFAR-FTUs huggingface dataset:
Tenofovir versus Entecavir on Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma After FOLFOX-Hepatic Arterial Infusion Chemotherapy

Purpose The efficacy of entecavir (ETV) versus tenofovir (TDF) on the prognosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients who underwent FOLFOX-hepatic arterial infusion chemotherapy (HAIC) remains unclear. In this study, we compared the outcomes between ETV and TDF in HBV-related advanced HCC patients who underwent FOLFOX-HAIC. Methods A total of 683 patients diagnosed with HBV-related HCC who underwent FOLFOX-HAIC and received TDF or ETV between January 2016 and December 2021 were included. Overall survival (OS), progression-free survival (PFS), HBV reactivation, and liver function of patients were compared between the ETV and TDF groups by propensity score matching (PSM). Results In the PSM cohort, for all patients and patients with ≥ 4 cycles of FOLFOX-HAIC, the median OS in the ETV group (15.2 months, 95% CI: 13.0–17.4 months; 16.6 months, 95% CI: 14.8–18.5 months; respectively) was shorter than that in the TDF group (23.0 months, 95% CI: 10.3–35.6 months; 27.3 months, 95% CI: 16.5-NA months; p=0.024, p=0.028; respectively). The median PFS in the ETV group (8.7 months, 95% CI: 7.9–9.5 months; 8.9 months, 95% CI: 8.0–9.8 months; respectively) was also shorter than that in the TDF group (11.8 months, 95% CI: 8.0–15.6 months; 12.7 months, 95% CI: 10.8–14.6 months; p=0.036, p=0.025; respectively). The rate of HBV reactivation in the ETV group was higher than that in the TDF group (12.3% vs 6.3%, p=0.040; 16.5% vs 6.2%, p=0.037, respectively). For liver function, the rate of ALBI grade that remained stable or improved in the ETV group was lower than that in the TDF group (44.6% vs 57.6%, p=0.006; 37.2% vs 53.8%, p=0.019, respectively). Conclusion Compared with ETV, TDF was associated with a better prognosis, lower proportion of HBV reactivation, and better preservation of liver function in advanced HBV-HCC patients who underwent FOLFOX-HAIC, especially those who received ≥ 4 cycles.
Ultrasonic compressional and shear velocities in dry clastic rocks as a function of porosity, clay content, and confining pressure

SUMMARY For clastic silicate rocks sampled from a Rotliegendes well core the velocities up and us were obtained at 10 pressures up to 300MPa using a pulse-transmission technique. The porosities of all rocks (57 sandstones, 26 siltstones, five claystones) ranged from 0.01 and 0.15 by volume fraction, and the clay content varied from less than 0.01 to 0.88 by volume fraction. Both velocities increase with pressure. In the low-pressure range the rate of increase is large, non-linear and is greater for up than for us. Above 120 MPa both velocities increase linearly. Velocities, porosity, and clay content were fitted by least-squares regression for pressures of 8, 24, 60, 120, 200, and 300 MPa. The fractional effect of porosity and clay on the velocities for dry clastic silicate rocks can be described (above 120 MPa) by u = A - B# - CCluy, where v is the velocity of the P-wave or S-wave, # is the volume fraction of pores, and Clay is the volume fraction of clay. From this it is possible to obtain pressure-dependent velocity functions u = a +pb - c exp (-dp), where u is the crack-free velocity, linear in porosity and clay, b is the velocity slope under high pressure, u - c is the zero-pressure velocity, and d is related to closure of cracks.
Determinant of online shopping intention: Satisfaction as an intermediary

Conducted with a sample size of 120, the research employed structural equation modeling for analysis. The findings revealed several influential factors, including perceived trust, perceived value, perceived risk, and satisfaction, impacting behavioral intentions among Indonesian online shoppers. Notably, satisfaction emerged as a mediating variable in the relationship between perceived trust, perceived value, perceived risk, and behavioral intentions. The implications suggest that businesses and online retailers seeking to enhance customer satisfaction and drive desired behaviors should consider strategies aligned with these influential factors. However, it is crucial for both researchers and practitioners to acknowledge the study's limitations. Further research endeavors are encouraged to broaden and refine our understanding of consumer behavior in the Indonesian online shopping landscape.
ON A NEW SUBSPECIES OF FRESH-WATER TROUT,BRACHYMYSTAX LENOK TSINLINGENSIS,FROM TAIPAISHAN, SHENSI, CHINA

This paper presents a new subspecies of fresh-water trout, collected from the regionof Tsinling Mountains (秦岭) in Shensi Province, China, during Autumn, 1962. Brachymystax lenok tsinlingensis, subsp. nov. Diagonosis: Closely resembling Brachymystax lenok lenok (Pallas), but distinguish-able by characters as given in the following table. A rather small carnivorous fish inhabiting mountain streams and generally feeding oninsects. Fish of 2-years-old attaining sexual maturity. So far as known, the fish is confined to the mountain streams, such as Su-shui(湑水) and Tai-pai-ho (太白河) (flowing into Han-kiang (汉江), a tributary of theYang-tze-kiang), Hei-ho (黑河) and Shih-tow-ho (石头河) (flowing into wei-ho(渭河), a tributary of the Yellow River). Types: Holotype No. H2067, ? , body length 246 mm, collected on August 23,1962, from How-chen-tze (厚珍子), Chow-tze-hsien (周至县), Shensi Province, China,at an altitude of about 1500 m. Paratypes (30 ? ), body length 165-275 mm, col-lected August 3-September 5, 1962, How-chen-tze, Chen-kia-ho (陈家河), Hei-shui-k'ow (黑水口), Du-tu-men (都督门), etc. All of the types are kept in the Institute ofZoology, Academia Sinica, Peking.
Study on the anti-vibrio activity of marine fungi Aspergillus sydowii and Rhizopus sp. using OSMAC Approach

Shrimp is one of the major aquaculture products in Indonesia. However, shrimp culture faces the peril of Vibriosis, a disease caused by the bacteria genus of Vibrio. Marine sponge-associate microbes are recognized for their potential as sources of antibacterial agent. The fungus Aspergillus sydowii isolate that used in this research originally isolated from marine sponge collected in Lampung Bay. The fungus was grown in various media e. g. Malt extract agar (MEA), MEA-Tempeh broth (MEA-T), and tofu dregs (TD) under various pH (5.5, 7.5, and 9.5). The fungus also be culture as mono-culture and co-culture with Rhizopus sp. The anti-vibrio assay was conducted using disk diffusion method. Based on anti-vibrio assay, the fungus A. sydowii and Rhizopus sp. didn’t show any correlation with the anti-vibrio compound produced. The fungus Rhizopus sp. cultivated in tofu dregs media (TD) at pH 5.5 exhibited the highest potential for inhibiting against V. alginolyticus (5.85±0.24 mm), V. harveyi (5.20±0.20 mm), and V. vulnificus (4.33±0.15 mm), while the co-culture (A. sydowii and Rhizopus sp.) in TD media and pH 7.5 against V. parahaemolyticus (5.55±0.86 mm). The fungus cultured in pH 7.5 can promotes the potential inhibition zone than a pH 9.5.
Innovative AETCOM session on health care as a right: Experience at the medical college in Puducherry

BACKGROUND: Attitude, Ethics, and Communication (AETCOM) module 2.3 is effective in improving the communication skills of medical students, which in turn will prevent malpractices and litigations against doctors. Module 2.3, ‘Health Care as a Right,’ was aimed at introducing healthcare systems, access, equity in access, the impact of socio-economic situation in determining healthcare access, the role of doctors as key players, and the missing links in the health care systems to students. MATERIALS AND METHODS: A teaching and learning activity was developed for MBBS professional year 2 on AETCOM 2.3. The activities planned were an introduction to the topic, a short documentary film using AV aids, role play by the team, group discussion followed by role play by the students, reflective writing, and finally summarizing the session with a take-home message. RESULTS: The number of responses received in reflective writing was 114. The thematic analysis of qualitative responses was grouped into categories The facilitating factors were the availability of trained doctors and round-the-clock services, and the hindering factors were disrespect to patients, professional misconduct, long waiting time, etc. The suggestions to improve communication between the doctor and the patient were to listen politely and develop good rapport. The qualities of a good doctor were good communication skills, empathy, professional conduct, etc. CONCLUSION: This AETCOM session helped the students understand the healthcare delivery system in the country. It changed their attitude toward patients and improved their communication skills as they were soon-to-become doctors.
Prevalence and prognosis of acute ischemic stroke coexisting with unruptured intracranial aneurysms

Objectives The prevalence of unruptured intracranial aneurysms (UIAs) in the acute ischemic stroke (AIS) cohort is probably higher than in the general population. This study investigated the prevalence of UIAs in AIS patients and the management risk and prognosis when treating AIS. Methods From January 2020 to January 2023, we conducted a single-center retrospective study at Tianjin Huanhu Hospital. Each patient underwent both brain MRI and MRA/CTA to diagnose AIS and UIAs. Clinical, radiologic, and therapeutic data during hospitalization and prognosis were analyzed. Propensity-score matching (PSM) was performed to evaluate the risk of in-hospital adverse events, unfavorable outcomes at discharge when receiving post-stroke treatment and stroke recurrence. Results In all, 2,181 AIS patients were included, of whom 270 had UIAs (12.4%; 95%CI 11.0–13.8%). From the unmatched and matched cohort, the incidence of in-hospital adverse events and unfavorable outcomes at discharge in patients with UIAs were not significantly different; the risk of stroke recurrence was significantly higher in patients with UIAs than in those without (unmatched: aHR, 1.71 [1.08–2.70]; matched: aHR, 2.55 [1.16–5.58]). Multivariable Cox regression models showed that aneurysm size and the presence of homoregional infarction associated with higher risk of recurrence (unmatched: aHR, 1.31 [1.21–1.41] and aHR, 3.50 [1.52–8.10]; matched: aHR, 1.28 [1.18–1.40]; p < 0.001 and aHR, 3.71 [1.12–12.34]). Conclusion The UIAs may not increase the risk of in-hospital adverse events and unfavorable outcomes at discharge in receiving post-stroke treatment, but it may associated with a high risk of stroke recurrence.
Fauna of Protected Areas - 23: Insect fauna of Peechi-Vazhani Wildlife Sanctuary, Kerala, India

© Zoo Outreach Organisation; www.zoosprint. org Manuscript 1280; Received 02 November 2004; Finally accepted 06 July 2005; Date of publication 21 July 2005 1955 August 2005 | ISSN 0971-6378 ABSTRACT In a study on the insect fauna of Peechi-Vazhani Wildlife Sanctuary, 374 species of insects mostly belonging to Lepidoptera, Coleoptera and Hemiptera were recorded. The fauna was rich and diverse and contained several rare and protected species. Among butterflies, of the 74 species recorded, six species (Chilasa clytia, Appias lyncida, Appias libythea, Mycalesis anaxias, Hypolimnas misippus and Castalius rosimon) are protected under the Indian Wildlife (Protection) Act. Similarly, four species of butterflies, Papilio buddha, Papilio polymnestor, Troides minos, and Cirrochroa thais, recorded in this study are rare and restricted in distribution. The moth fauna is rich in arboreal feeding forms indicating an undisturbed forest patch in the area. Certain species associated with herbaceous ground vegetation are of economic importance, being already reported as pests of various agricultural crops. Beetles are also abundant, being dominated by phytophagous and scavenger forms, the former feeding mostly on herbaceous ground flora and the latter associated with animal excreta. The bugs recorded in this study included mostly phytophagous forms. The hymenopterans contained several species of solitary bees and wasps. An inventory of 382 species of insects recorded from the Sanctuary is given.
Structure of the Martian Crust Below InSight From Surface Waves and Body Waves Generated by Nearby Meteoroid Impacts

We measure group velocity dispersion of surface waves generated by two meteoroid impacts on Mars close to the lander of the InSight mission. This allows us to probe the crustal structure in the first few kilometers beneath the InSight lander. In combination with body wave arrival times from five impact events, we obtain direct seismic constraints on the seismic velocity of the crust in the vicinity of the InSight landing site. We confirm the existence of a uppermost low‐velocity layer with a mean thickness of ∼1.2 km, interpreted as layered volcanic materials, possibly interstratified with sedimentary and altered materials. Our joint inversion of surface and body waves shows a four‐layer model for the Martian crust, compatible with high‐ and low‐frequency P‐to‐S receiver functions estimated in previous studies.
Diatom communities across a gradient of acid mine drainage on the West Coast, South Island, New Zealand

i Acknowledgements . iii Chapter 1: Introduction . 1 1.1. Coal mining in New Zealand . 1 1.2. Acid mine drainage and its biotic effects . 2 1.3. Diatoms in streams receiving AMD . 4 1.4. Diatoms in naturally acidic streams . 6 1.5. Diatoms as environmental indicators . 7 1.6. Thesis structure . 8 Chapter 2: Illustrated guide to diatoms in streams on the West Coast, South Island, New Zealand . 11 2.
Transport of Bottom Water in the Romanche Fracture Zone and the Chain Fracture Zone

Abstract Two moored arrays deployed in the Romanche Fracture Zone and Chain Fracture Zone in the equatorial Atlantic Ocean provide two-year-long time series of current and temperature in the Lower North Atlantic Deep Water and the Antarctic Bottom Water. Total time-averaged transport of Antarctic Bottom Water (potential temperature θ < 1.9°C) across the Mid-Atlantic Ridge amounts to 1.22 × 106 m3 s−1 eastward with a standard deviation of ±0.25 × 106 m3 s−1. A time-averaged transport of 0.36(± 0.23) × 106 m3 s−1 eastward is found for the Lower North Atlantic Deep Water in the 1.9° < θ < 2.1°C temperature range, but this may represent only a fraction of the total flow of this water mass across the ridge. Contributions of the Romanche Fracture Zone and Chain Fracture Zone to the Antarctic Bottom Water transport are similar, while the Chain Fracture Zone has the greater share of Lower North Atlantic Deep Water transport. Semiannual and annual periods are detected in the transport time series and together expl.
Immunogenicity, Efficacy, and Safety of a Novel Synthetic Microparticle Pre-Erythrocytic Malaria Vaccine in Multiple Host Species

We previously reported a protective antibody response in mice immunized with synthetic microparticle vaccines made using layer-by-layer fabrication (LbL-MP) and containing the conserved T1BT* epitopes from the P. falciparum circumsporozoite protein. To further optimize the vaccine candidate, a benchtop tangential flow filtration method (LbL-by-TFF) was developed and utilized to produce vaccine candidates that differed in the status of base layer crosslinking, inclusion of a TLR2 ligand in the antigenic peptide, and substitution of serine or alanine for an unpaired cysteine residue in the T* epitope. Studies in mice revealed consistent superiority of the Pam3Cys-modified candidates and a modest benefit of base layer crosslinking, as evidenced by higher and more persistent antibody titers (up to 18 months post-immunization), a qualitative improvement of T-cell responses toward a Th1 phenotype, and greater protection from live parasite challenges compared to the unmodified prototype candidate. Immunogenicity was also tested in a non-human primate model, the rhesus macaque. Base layer-crosslinked LbL-MP loaded with T1BT* peptide with or without covalently linked Pam3Cys elicited T1B-specific antibody responses and T1BT*-specific T-cell responses dominated by IFNγ secretion with lower levels of IL-5 secretion. The Pam3Cys-modified construct was more potent, generating antibody responses that neutralized wild-type P. falciparum in an in vitro hepatocyte invasion assay. IgG purified from individual macaques immunized with Pam3Cys.T1BT* LbL-MP protected naïve mice from challenges with transgenic P. berghei sporozoites that expressed the full-length PfCS protein, with 50–88% of passively immunized mice parasite-free for ≥15 days. Substitution of serine for an unpaired cysteine in the T* region of the T1BT* subunit did not adversely impact immune potency in the mouse while simplifying the manufacture of the antigenic peptide. In a Good Laboratory Practices compliant rabbit toxicology study, the base layer-crosslinked, Pam3Cys-modified, serine-substituted candidate was shown to be safe and immunogenic, eliciting parasite-neutralizing antibody responses and establishing the dose/route/regimen for a clinical evaluation of this novel synthetic microparticle pre-erythrocytic malaria vaccine candidate.
Sexual Identity–Behavior Discordant Heterosexuals in Britain: Findings from the National Survey of Sexual Attitudes and Lifestyle 2010–2012 (Natsal-3)

This study delves into heterosexual identity–behavior discordance, exploring the interaction between sexual identification and behavior in the UK. Analyzing representative 2010 data from the British population (N = 12,472), this research categorizes participants into different groups: nonheterosexual, concordant heterosexual, and three discordant heterosexual categories (closeted, experimenters, and desisters). These groups were compared in terms of sociodemographics, attitudes toward sexuality, risk behaviors, and health indicators. Discordance was associated with permissive social attitudes, including behaviors such as adultery and one-night stands, and with increased substance abuse and risky sexual behaviors, especially among the closeted. Surprisingly, the physical and mental health of discordant heterosexuals was similar to concordant heterosexuals, in contrast to the poorer health of nonheterosexuals. Due to the significant variations in lifestyles and health indicators among different groups, this study highlights the importance of providing targeted services and interventions.
Gas flow in anisotropic claystone: modelling triaxial experiments

Selected gas pulse tests on initially saturated claystone samples under isotropic confinement pressure are simulated using a 3D thermo‐hydro‐mechanical code. The constitutive model considers the hydro‐mechanical anisotropy of argillaceous rocks. A cross‐anisotropic linear elastic law is adopted for the mechanical behaviour. Elements for a proper modelling of gas flow along preferential paths include an embedded fracture permeability model. Rock permeability and its retention curve depend on strains through a fracture aperture. The hydraulic and mechanical behaviours have a common anisotropic structure. Small‐scale heterogeneity is considered to enhance the initiation of flow through preferential paths, following the direction of the bedding planes. The numerical simulations were performed considering two different bedding orientations, parallel and normal to the imposed flow in the test. Simulations are in agreement with recorded upstream and downstream pressures in the tests. The evolution of fluid pressures, degree of saturation, element permeability and stress paths are presented for each case analysed. This information provides a good insight into the mechanisms of gas transport. Different flow patterns are obtained depending on bedding orientation, and the results provide an explanation for the results obtained in the tests. Copyright © 2012 John Wiley & Sons, Ltd.
Exploring the Relationship Between Work–Family Conflict, Family–Work Conflict and Job Embeddedness: Examining the Mediating Role of Emotional Exhaustion

Purpose The purpose of this study is to examine the relationships between family–work conflicts, work–family conflicts, emotional exhaustion, and job embeddedness. Emotional exhaustion was hypothesized to mediate relations between family–work conflicts, work–family conflicts and job embeddedness. Methods An online questionnaire was distributed to collect the data. The sample consisted of 264 women aged 18 years and older who work in private sector in Saudi Arabia. Confirmatory Factor Analysis (CFA), common method bias (CMB), and structural equation modeling (SEM) were conducted using AMOS (Version 28). Results The results show that emotional exhaustion functions as a full meditator of the relationship between work–family conflicts, family–work conflicts and job embeddedness. Specifically, women who experience work and family conflicts are unable to balance heavy workloads are emotionally exhausted which in turn affects their job embeddedness. Conclusion The study emphasizes the negative effects of both work-to-family and family-to-work-life spillover that result in unfavorable psychological states for female employees. Therefore, it is essential for organizations to have interventions that support balancing the demands of family and work. Organizations need to consider how much control an employee has over the time and location of their job. Organizations must also provide clear procedures for handling flexible work schedules and part-time employment.
A THEORETICAL REVIEW OF VOCABULARY ACQUISITION LEVEL AND ITS INFLUENCE ON STUDENTS READING COMPREHENSION

Reading is a creative way to actively and positively acquire information and to develop students' ability to perceive and access information visually through writing. At the same time, vocabulary is a foundation for reading. The relationship between English vocabulary level and reading comprehension ability are studied by different scholars, especially the relationship between these two variables. Supported by different findings, most of these researchers have found that there is a high correlation between English vocabulary level and reading comprehension ability. An indication is that English language learners' reading comprehension is generally influenced by how much vocabulary they know. The implication is that, as vocabulary contributes to students' understanding of what they read, reading must be part of their learning to improve their vocabulary and one of the essential components of language learning that could lead to their overall language proficiency.
Conformal Mapping for Channel Junction Flow

An analysis of the flow behavior at rectangular channel junctions with combining flow using the conformal mapping technique has been presented. Equations for the location of the stagnation point and the free-streamline for different flow conditions at rectangular channel junctions have been developed. These equations have been solved numerically by using Simpsons rule. It is observed that for each channel junction there is a unique value of discharge ratio corresponding to which the stagnation point coincides with the upstream corner of the junction. The value of the discharge ratio depends on the junction angle as well as on the bed-widths of the channels. It is also indicated that the zone of stagnant fluid between the free-streamline and the channel boundary depends on the junction angle and the location of the stagnation point.