Miracle-dz/UniFAR-FTUs huggingface dataset:
ERCC1 19007 Polymorphism in Greek Patients with Advanced Urothelial Cancer Treated with Platinum-Based Chemotherapy: Effect of the Changing Treatment Paradigm: A Cohort Study by the Hellenic GU Cancer Group

We previously showed that ERCC1 19007 C>T polymorphism was associated with cancer-specific survival (CSS) after platinum-based chemotherapy in patients with advanced urothelial cancer (aUC). We aimed to confirm this association in a different cohort of patients. Genotyping of the 19007C>T polymorphism was carried out by polymerase chain reaction (PCR) amplification and restriction fragment length polymorphism (RFLP) in 98 aUC patients, treated with platinum-based chemotherapy. Median age of the patients was 68.8, 13.3% of them were female, 90.8% had ECOG PS of 0 or 1, and 48% received cisplatin-based chemotherapy. In addition to chemotherapy, 32.7% of the patients received immunotherapy, and 19.4% vinflunine. Eighty-one patients (82.7%) were carriers of the 19007T polymorphic allele: 46 (46.9%) were heterozygotes, and 35 (35.7%) were homozygotes. The ERCC1 polymorphism was not associated with CSS, progression-free (PFS), or overall (OS) survival in the total population. Nevertheless, there was a significant interaction between the prognostic significance of ERCC1 polymorphism and the use of modern immunotherapy: the T allele was associated with worse outcome in patients who received chemotherapy only, while this association was lost in patients who received both chemotherapy and immune checkpoint inhibitors. Our study suggests that novel therapies may influence the significance of ERCC1 polymorphism in patients with aUC. Its determination may be useful in the changing treatment landscape of the disease.
Does the Inclusion of Atrazine in S-Metolachlor/Mesotrione/Bicyclopyrone Improve Glyphosate-Resistant Canada Fleabane Control in Corn?

A total of seven field studies were conducted in southwestern Ontario from 2018 to 2020 to evaluate S-metolachlor/mesotrione/bicyclopyrone (Acuron Flexi®) and S-metolachlor/atrazine/mesotrione/bicyclopyrone (Acuron®) for the control of glyphosate-resistant (GR) Canada fleabane in corn. Acuron Flexi® and Acuron® applied preplant (PP) controlled GR Canada fleabane 90-97% and 99-100%, respectively. Commonly used PP herbicides in Ontario, dicamba/atrazine + glyphosate and tolpyralate + atrazine + glyphosate controlled GR Canada fleabane 97-99%. Acuron Flexi® and Acuron® applied postemergence (POST) provided 75-92% and 92-99% control of GR Canada fleabane, respectively. Dicamba/atrazine + glyphosate and tolpyralate + atrazine + glyphosate applied POST provided 84-97% and 94-98% control of GR Canada fleabane, respectively. Glyphosate applied POST at 900 ae ha-1 provided only 35-38% control of Canada fleabane in corn. Orthogonal contrasts indicated that herbicides applied PP provided up to 10% greater control of GR Canada fleabane than POST. There was no significant difference between the low and high rates of Acuron® or Acuron Flexi® in controlling GR Canada fleabane. Acuron® controlled GR Canada fleabane 14, 9 and 7% greater than Acuron Flexi® at 4, 8, and 12 WAA, respectively. GR Canada fleabane interference with corn reduced yield up to 42%. However, there was no difference in corn yield between herbicides treatments evaluated. Orthogonal contrasts indicated that reduced GR Canada fleabane interference with PP herbicides evaluated provided 0.9 t ha-1 greater corn yield than the POST herbicides evaluated. There was no significant difference in corn yield with Acuron® or Acuron Flexi® at the lower rate or higher rates. Additionally, Acuron Flexi® applied PP provided a similar corn yield as when applied POST. Based on these results, the use of Acuron® results in improved GR Canada fleabane control than Acuron Flexi® but this did not result in an increase in corn yield. The study concludes that there is potential for Acuron Flexi® for GR Canada fleabane control in corn especially in areas where atrazine use is restricted, however additional weed control tactics may be required for acceptable control.
Jump height of overhead-line conductors after the sudden release of ice loads

A series of tests was performed on a five-span section of 132kV line to determine the jump height of the conductors after the release of simulated ice loads from the centre span. The use of semitension assemblies at the suspension towers reduced the maximum jump height compared with that obtained with standard suspension-insulator strings, but did not prevent the phase conductors from passing dangerously close to each other. The importance of the sag in determining the jump height is stressed, and experimental and theoretical values for sag and jump height are compared. It was shown experimentally that the large sag differences resulting from some arrangements of ice loading brought phase conductors close together, and that the clearance to ground of the bottom conductor of the loaded span was reduced below the safety level for ice loads in excess of 1 lb/ft. It is concluded that, with heavy ice loads, phase-to-phase flashover can only be prevented by ensuring sufficient horizontal separation between phases.
Effects of Sargassum wightii Methanolic Extract on L-Methionine Induced Experimental Vascular Dementia like Syndrome in Albino Wistar Rats

Sargassum wightii is brown seaweeds with high nutritive value with natural bioactive compounds having diverse therapeutic activity. In recent years, research on Sargassum wightii has gain much interest in neuropharmacological field. Basing on neuroprotective effect of Sargassum wightii against Parkinson’s disease animal models, the possible protective effect on dementia is hypothesised. Addressing this question the present study was designed to investigate the effect of S. wightii on L-methionine induced vascular dementia like syndrome in male wistar albino rats. Vascular dementia was induced by oral administration of L-methionine (1.7 g/kg) per body weight for 4weeks S. wightii was given from day1 to day32. The neurobehavioral assessment was performed by Morris water maze test for learning and memory ability and blood sample was collected for serum nitrite and homocysteine analysis. The whole brain content was subjected to a series of biochemical analysis that included brain cholinesterase, malondialdehyde, reduced glutathione and histopathological examination. L-methionine impaired learning and memory, increased serum homocysteine and decreased serum nitrite level significantly (p<0.001). It also increased brain thiobarbituric acid reactive substances, reduced glutathione and increased acetylcholinesterase activity significantly (p<0.001). Sargassum wightii at 200mg/kg and 400mg/kg body weight reversed the L-methionine induced learning and memory deficits (p<0.01) and (p<0.001) respectively. The L-methionine induced biochemical alterations in serum and brain as well as histopathological aberration in cortex and hippocampus were restored by Sargassum wightii (p<0.01). This study concluded that Sargassum wightii ameliorated L-methionine induced vascular dementia like syndrome and provided a new concept in anti-dementia therapy as a neuroprotectants.
TECNOLOGIAS DE INFORMAÇÃO E COMUNICAÇÃO NA OFERTA DE SERVIÇOS FINANCEIROS PARA A POPULAÇÃO DE BAIXA RENDA: OS CORRESPONDENTES BANCÁRIOS DO BANCO LEMON INFORMATION AND COMMUNICATION TECHNOLOGIES TO DELIVER FINANCIAL SERVICES FOR THE LOW-INCOME POPULATION: CORRESPONDENT BANKING AT BANCO LEMON

Brazilian banks have developed innovative initiativ es to deliver financial services for the lowincome population through correspondent banking (CB). Banco Lemon is such an interesting case to be studied because it has implemented a bus iness model based exclusively on CB outlets and its focus was on low-income clients. This paper describes Banco Lemon’s adoption process of the CB technology to deliver financial services for the low-income population, promoting a historical description of the bank’s activities, si nce its creation and up to the year 2009. Eventually, this paper concludes that bill payment initiatives were successful while credit initiatives led to unexpressive outcomes.
Daily variation feeding of Astyanax lacustris (Lütken 1875) in a subtropical river

This study aimed to know the daily variation of Astyanax lacustris (Lütken 1875) feeding in a lotic environment. Fish were caught with a net for three days every three hours in the summer to capture ten individuals per hour in a stretch of the Ijuí River, Middle Uruguay River, Brazil. The captured specimens had their stomachs removed and the content analyzed and separated into seven food categories with the aid of stereomicroscope. For the analysis of food items were used the frequency of occurrence methods, volumetric method and applied the Alimentary Index (IAi). Two hundred stomachs were analyzed, of which 95% had food content. The most abundant items were algae and autochthonous insects. Astyanax lacustris feeds throughout the day especially early in the morning (9 hours) and reduces its feeding at night (24 hours and 3 hours). It was also verified variation of AI of different food items throughout the day. It is concluded that A. lacustris feeds throughout the day, especially in the daytime and that throughout the 24 hours it varies its diet due to photoperiod and food availability.
Investigation the Effects of Phenylephrine on Oxytocin-Induced Hemodynamic Changes in Women Undergoing Cesarean Section

Pregnancy is considered as one of the most important events in every woman's life, which is not a pleasant event for all women, and in cases where the stages are not managed properly, it can cause a lot of stress on the mother and her family. For this reason, the present study was conducted to investigate the effect of phenylephrine on oxytocin-induced hemodynamic changes. This study was conducted on a group of pregnant women referred to Ayatollah Taleghani Hospital in Ilam and those undergoing cesarean section were included in the study. The objectives of the study explained to the women participating in the study, whether the participation was voluntary or not to participate in the intervention, compliance with the Helsinki and Belmont Declaration, and confidentiality of information. The women included in the study were randomly assigned to experimental and control groups. The checklists of the researchers were completed by observing and asking the patients from the time the patient entered the hospital until the end of the surgery. The variables expected by the researchers were evaluated before the intervention and 2, 4, 6, 8, 10 and 12 minutes after the intervention. In the experimental group, 12 (30%) patients had no nausea, 18 (45%) patients had low nausea, 8 (20%) patients had moderate nausea and 2 (5%) patients had severe nausea. While in the control group, 5 (12.5%) patients had no nausea, 13 (32.5%) patients had low nausea, 14 (35%) patients had moderate nausea and 8 (20%) patients had severe nausea. Also, a significant difference was between in the experimental and control groups in terms of nausea (P = 0.02). The study results showed that using phenylephrine can be effective on improving blood pressure, heart rate, nausea and vomiting in patients, which for this reason it is recommended to use this drug to improve the health of women undergoing cesarean section.
From Atmospheric Waves to Heatwaves A Waveguide Perspective for Understanding and Predicting Concurrent, Persistent, and Extreme Extratropical Weather

: A notable number of high-impact weather extremes have occurred in recent years, often associated with persistent, strongly meandering atmospheric circulation patterns known as Rossby waves. Because of the high societal and ecosystem impacts, it is of great interest to be able to accurately project how such extreme events will change with climate change, and to predict these events on seasonal-to-subseasonal (S2S) time scales. There are multiple physical links connecting upper-atmosphere circulation patterns to surface weather extremes, and it is asking a lot of our dynamical models to accurately simulate all of these. Subsequently, our confidence in future projections and S2S forecasts of extreme events connected to Rossby waves remains relatively low. We also lack full fundamental theories for the growth and propagation of Rossby waves on the spatial and temporal scales relevant to extreme events, particularly under strongly nonlinear conditions. By focusing on one of the first links in the chain from upper-atmospheric conditions to surface extremes—the Rossby waveguide—it may be possible to circumvent some model biases in later links. To further our understanding of the nature of waveguides, links to persistent surface weather events and their representation in models, we recommend exploring these links in model hierarchies of increasing complexity, developing fundamental theory, exploiting novel large ensemble datasets, harnessing deep learning, and increased community collaboration. This would help increase understanding and confidence in both S2S predictions of extremes and of projections of the impact of climate change on extreme weather events. show a single relatively high-value contour (0.001 km −1 ) of the zonally smoothed horizontal gradient of ln(PV) on two different isentropic surfaces (320 and 340 K), highlighting regions of high horizontal gradients in ln(PV). Both of the black contours are qualitative proxies for the presence of Rossby waveguides.
Dynamic tax competition between symmetric countries with multiple strategic investors

Two symmetric countries compete over two-period under a non-preferential taxation regime to attract multiple investors where investors are strategic and investments are sunk once invested. Contrary to the existing results, we find that tax holidays do not arise during the initial period. Equilibria in mixed strategies arise in both periods where competing countries set strictly positive tax rates during the initial period. Strategic interaction between large investors reduces competition and increases tax rates during the initial period. We provide full characterization and uniqueness of equilibria in mixed strategies.JEL classification: F21, H21, H25, H87
A Review of Motion Sickness with Special Reference to Simulator Sickness

Simulator sickness has implications for training and safety because as many incidents of simulator sickness have been reported since 1980 as in all the previous time. The signs and symptoms, stimulus and response characteristics, anatomical structures, and susceptibility factors of simulator sickness are reviewed. The prevalent theories of the genesis of this malady are put forth and an integrating theory, which suggests that simulator sickness is a form of motion sickness and may be best understood as a special case of sensory conflict, is proposed. Sensory conflict is a useful principle in the study of simulator sickness because the malady is clearly polygenic and polysymptomatic. Therefore it may be argued that greater conflict leads to more severe and greater incidence of sickness. Evaluations that will lead to recommendations for preventing the problem, guidelines for predicting the outcome, and suggestions for future research may be planned.
A Comprehensive Review of Small-Signal Stability and Power Oscillation Damping through Photovoltaic Inverters

This paper focuses on the methods that ensure the rotor angle stability of electric power systems, which is most frequently analyzed with small-signal models. Over the past several decades, power system stabilizers (PSSs) for conventional excitation systems were the main tools for improving the small-signal stability of electromechanical oscillatory modes. In the last decade, power oscillation damping (POD) control implemented in photovoltaic (PV) inverters has been considered an alternative to PSSs. As PV generation undergoes massive rollout due to policy directions and renewable energy source integration activities, it could potentially be used as a source of damping, which is crucial for sustaining the rotor angle stability of the remaining in-service synchronous generators. Several studies have already been dedicated to the development of different damping strategies. This paper contributes to the existing research in power system stability by providing a comprehensive review of the effects of PV generation on small-signal stability, as well as the recent evolution of POD control through PV inverters. The features and impacts of the various ways to realize POD controllers are assessed and summarized in this paper. Currently, detailed information and discussions on the practical application of PV inverter PODs are not available. This paper is, thus, intended to initiate a relevant discussion and propose possible implementation approaches concerning the topic under study.
Loose Fluid-Structure Coupled Approach for a Rotor in Descent Incorporating Fuselage Effects

A loose coupling approach is used to combine a comprehensive structural dynamics code CAMRAD II and a computational fluid dynamics solver KFLOW to validate the data and to identify the effect of fuselage on the aeroelastic behavior of the second higher harmonic rotor acoustic test rotor. The computations are made using isolated rotor and rotor–fuselage models. To demonstrate the effect of a fuselage, the shaft tilt angles remain identical for both configurations. A good correlation has been obtained with the present computational fluid dynamics/comprehensive structural dynamics method. It is observed that a rotor–fuselage model improves the correlation significantly in terms of magnitudes and phases of the airloads solution. All the blade–vortex interaction peaks are captured accurately, and the phase shift in the section normal forces improves significantly, with the inclusion of a fuselage. The sources of improvements are investigated, considering the vorticity distributions and induced velocity fields .
Lumbar Loads and Muscle Activity During Flywheel and Barbell Leg Exercises

Abstract Sjöberg, M, Eiken, O, Norrbrand, L, Berg, HE, and Gutierrez-Farewik, EM. Lumbar loads and muscle activity during flywheel and barbell leg exercises. J Strength Cond Res 37(1): 27–34, 2023—It is anticipated that flywheel-based leg resistance exercise will be implemented in future long-duration space missions, to counter deconditioning of weight-bearing bones and postural muscles. The aim was to examine low back loads and muscle engagements during flywheel leg press (FWLP) and flywheel squat (FWS) and, for comparisons, free-weight barbell back squat (BBS). Eight resistance-trained subjects performed 8 repetition maximums of FWLP, FWS, and BBS. Motion analysis and inverse dynamics-based musculoskeletal modeling were used to compute joint loads and muscle forces. Muscle activities were measured with electromyography (EMG). At the L4–L5 level, peak vertebral compression force was similarly high in all exercise modes, whereas peak vertebral posteroanterior shear force was greater (p < 0.05) in FWLP and BBS than in FWS. Among the back-extensor muscles, the erector spinae longissimus exerted the greatest peak force, with no difference between exercises. Peak force in the lumbar multifidus was lower (p < 0.05) during FWLP than during FWS and BBS. Peak EMG activity in the lumbar extensor muscles ranged between 31 and 122% of maximal voluntary isometric contraction across muscles and exercise modes, with the greatest levels in the lumbar multifidus. The vertebral compression forces and muscle activations during the flywheel exercises were sufficiently high to presume that when implementing such exercise in space countermeasure regimens, they may be capable of preventing muscle atrophy and vertebral demineralization in the lumbar region.
A study of sustainability of continuous improvement in the manufacturing industries in Malaysia : Organizational self‐assessment as a mediator

Purpose – The purpose of this paper is to investigate the influence of six variables: strategic focus; monitoring continuous improvement development; integration of continuous improvement; management of continuous improvement; involvement/engagement and learning; and knowledge sharing, on sustainability of continuous improvement capabilities in the context of the manufacturing industries in Penang, Malaysia. The paper determines the impact of organizational self‐assessment towards the relationship of these six factors and sustainability of continuous improvement capabilities.Design/methodology/approach – The study opted for an exploratory study using the survey instrument to collect data. The questionnaire was published through the web and manual distribution. For the web survey, e‐mails were broadcasted to invite the random employees to participate in the e‐mail survey, where respondents were directed to answer the attachment that contained the questionnaire. Online survey method is chosen because it is .
Evaluation of one of leading Indonesia’s digital wallet using the unified theory of acceptance and use of technology

The goal of this research is to assess the utilization of one of Indonesia's most popular digital wallets. Respondents in this study range in age from 15 to 44 years old and live on Java Island. The author employs the unified theory of acceptance and utilization of technology (UTAUT) paradigm to assess the use of this digital wallet. This UTAUT model comprises four latent variables that affect behavioral intention (BI) and use behavior (UB): performance expectancy (PE), effort expectancy (EE), social influence (SI), and facilitating conditions (FC). In this study, the UTAUT model is combined with two additional variables: perceived risk (PR) and promotional benefits (PB). According to the findings, performance expectancy, social influence, and perceived risk all have an impact on behavioral intention, whereas effort expectancy has a less impact. Furthermore, the factors facilitating conditions and promotional benefits have a minor impact on use behavior, whereas behavioral intention factors have a considerable impact on use behavior.
Palm Creases Analysis in Students and Staff of a Teaching Hospital in Kathmandu

Introduction: Palm creases have been studied for a long time and have been recently found to be helpful in tracking underlying medical and genetic conditions. Scientific study and typing of palm prints have been found to be lacking in the Nepalese population Methods: A cross sectional study was done on 252 subjects, 153 male and 99 females, from Kathmandu, Nepal. Subjects were selected by purposive sampling from different age groups. Demographic profile including age, sex, and handedness was collected. Palm print pattern was recorded by digital photography. Each photograph was analysed visually by single observer and pattern of palm crease was noted. Variation of each crease was also noted. Results: On the basis of relation between radial longitudinal crease and proximal transverse crease, 17.3% subjects had open type of palm crease which was significantly more in females while 76.6% subjects had closed type crease which was significantly more in males. Meeting type of palm crease was found in 5.7% of subjects. On the basis of relation between proximal and distal transverse crease, normal crease type was found in 90.1% of subjects, Simian type was found in 7.7% subjects and Sydney type was found in 1.4% of subjects. The concordance of this pattern in left and right palms was found statistically significant. Conclusions: This study presented data from 252 seemingly normal healthy subjects and found that most of them had the normal with no branching, that is normal 1 and closed crease types. Most of the individual major creases were seen to be branched type.