Miracle-dz/UniFAR-FTUs huggingface dataset:
Visual impairment and falls as risk factors of orthopaedic fractures

The musculoskeletal system represents one of the most affected systems in general traumatology. Fractures of the locomotor system and their effects are among the most severe and demanding injuries for the community in general and for the health system in particular. There are different factors that have been established as risk factors for fractures, with falls representing the main cause. Given the fact that vision has a key role in preserving gait and balance, various conditions of visual impairments have been related to an increase in fall-related injuries, and fractures of the locomotor system, especially in older population. Indeed, with an increased life expectancy, there is a rise in the number of visually impaired individuals and subsequently a rise in the number of falls and fractures. In this study, a review of the incidence and risk factors of musculoskeletal system fractures and falls was conducted, with the incidence of visual impairments in the general population. Another review of different types of visual impairments was done that included potential risk factors for fractures, falls and soft tissue injuries of the hand and if there has been any association between these specific visual impairments and the risk of falling, getting a fracture or a soft tissue injury of the hand.
Causal effects of the gut microbiome on COVID-19 susceptibility and severity: a two-sample Mendelian randomization study

Background The coronavirus disease 2019 (COVID-19) caused a global pandemic, with potential severity. We aimed to investigate whether genetically predicted gut microbiome is associated with susceptibility and severity of COVID-19 risk. Methods Mendelian randomization (MR) analysis of two sets with different significance thresholds was carried out to infer the causal relationship between the gut microbiome and COVID-19. SNPs associated with the composition of the gut microbiome (n = 5,717,754) and with COVID-19 susceptibility (n = 14,328,058), COVID-19 severity (n = 11,707,239), and COVID-19 hospitalization (n = 12,018,444) from publicly available genome-wide association studies (GWAS). The random-effect inverse variance weighted (IVW) method was used to determine causality. Three more MR techniques—MR Egger, weighted median, and weighted mode—and a thorough sensitivity analysis were also used to confirm the findings. Results IVW showed that 18 known microbial taxa were causally associated with COVID-19. Among them, six microbial taxa were causally associated with COVID-19 susceptibility; seven microbial taxa were causally associated with COVID-19 severity ; five microbial taxa were causally associated with COVID-19 hospitalization. Sensitivity analyses showed no evidence of pleiotropy or heterogeneity. Then, the predicted 37 species of the gut microbiome deserve further study. Conclusion This study found that some microbial taxa were protective factors or risky factors for COVID-19, which may provide helpful biomarkers for asymptomatic diagnosis and potential therapeutic targets for COVID-19.
Lineage Plasticity and Stemness Phenotypes in Prostate Cancer: Harnessing the Power of Integrated “Omics” Approaches to Explore Measurable Metrics

Simple Summary Prostate cancer remains the most frequent cause of cancer morbidity, the second most frequent cause of cancer mortality in men in the developed world and is an exemplar of a heterogeneous disease. Stemness phenotypes and lineage plasticity have been highlighted as key drivers of heterogeneity observed both across patients and within the same patient. However, markers that indicate the presence or absence of these events remain to be identified. Next-generation sequencing has proven to be a beneficial approach to distinguish predictive and prognostic biomarkers in various diseases, including prostate cancer. This review explores measurable metrics that can reliably reflect lineage plasticity at the genomic, transcriptomic, and epigenomic levels, as well as bioinformatic tools that can be used to identify measures of lineage-plasticity in prostate cancer, in order to inform preclinical and clinical research. Abstract Prostate cancer (PCa), the most frequent and second most lethal cancer type in men in developed countries, is a highly heterogeneous disease. PCa heterogeneity, therapy resistance, stemness, and lethal progression have been attributed to lineage plasticity, which refers to the ability of neoplastic cells to undergo phenotypic changes under microenvironmental pressures by switching between developmental cell states. What remains to be elucidated is how to identify measurements of lineage plasticity, how to implement them to inform preclinical and clinical research, and, further, how to classify patients and inform therapeutic strategies in the clinic. Recent research has highlighted the crucial role of next-generation sequencing technologies in identifying potential biomarkers associated with lineage plasticity. Here, we review the genomic, transcriptomic, and epigenetic events that have been described in PCa and highlight those with significance for lineage plasticity. We further focus on their relevance in PCa research and their benefits in PCa patient classification. Finally, we explore ways in which bioinformatic analyses can be used to determine lineage plasticity based on large omics analyses and algorithms that can shed light on upstream and downstream events. Most importantly, an integrated multiomics approach may soon allow for the identification of a lineage plasticity signature, which would revolutionize the molecular classification of PCa patients.
The Relationship between Perceived Overqualification and Organizational Citizenship Behavior and Affective Organizational Commitment

THE RELATIONSHIP BETWEEN PERCEIVED OVERQUALIFICATION AND ORGANIZATIONAL CITIZENSHIP BEHAVIOR AND AFFECTIVE ORGANIZATIONAL COMMITMENT: A MODERATING ROLE OF PERCEIVED ORGANIZATIONAL SUPPORT by Mariem Laaraj The present research aimed to investigate the moderating effect of perceived organizational support (POS) on the relationship between perceived overqualification, organizational citizenship behavior (OCB), and affective organizational commitment. A sample of 110 employees from a variety of occupational backgrounds in the United States participated in the study by completing an online survey. Results of hierarchical multiple regression analyses showed that POS did not act as a moderator of the relationship between perceived overqualification and OCB and affective organizational commitment. However, perceived overqualification was found to be significantly and negatively related to affective organizational commitment. Results also showed that POS was negatively related to perceived overqualification and positively related to OCB and affective organizational commitment. Organizational strategies to maximize POS were suggested.
“Spotting” Mycobacterium bovis infection in leopards (Panthera pardus) – novel application of diagnostic tools

Background Mycobacterium bovis (M. bovis) is the causative agent of animal tuberculosis (TB) which poses a threat to many of South Africa’s most iconic wildlife species, including leopards (Panthera pardus). Due to limited tests for wildlife, the development of accurate ante-mortem tests for TB diagnosis in African big cat populations is urgently required. The aim of this study was to evaluate currently available immunological assays for their ability to detect M. bovis infection in leopards. Methods Leopard whole blood (n=19) was stimulated using the QuantiFERON Gold Plus In-Tube System (QFT) to evaluate cytokine gene expression and protein production, along with serological assays. The GeneXpert® MTB/RIF Ultra (GXU®) qPCR assay, mycobacterial culture, and speciation by genomic regions of difference PCR, was used to confirm M. bovis infection in leopards. Results Mycobacterium bovis infection was confirmed in six leopards and individuals that were tuberculin skin test (TST) negative were used for comparison. The GXU® assay was positive using all available tissue homogenates (n=5) from M. bovis culture positive animals. Mycobacterium bovis culture-confirmed leopards had greater antigen-specific responses, in the QFT interferon gamma release assay, CXCL9 and CXCL10 gene expression assays, compared to TST-negative individuals. One M. bovis culture-confirmed leopard had detectable antibodies using the DPP® Vet TB assay. Conclusion Preliminary results demonstrated that immunoassays and TST may be potential tools to identify M. bovis-infected leopards. The GXU® assay provided rapid direct detection of infected leopards. Further studies should aim to improve TB diagnosis in wild felids, which will facilitate disease surveillance and screening.
The Effect of Authentic Leadership, Organizational Learning and Technological Innovation on Company Performance With Strategic Management Accounting As An Intervening Variable (Empirical Study on Banking in Banten Province)

This study aims to examine the effect of Authentic Leadership, Organizational Learning, Technological Innovation on Company Performance with Strategic Management Accounting as an intervening variable. The type of this study was quantitative, data collected by using primary data and questionnaires to obtained the information from the respondents, they were Middle Manager who worked in Main-Branch Office of Banking in Banten Province. The analytical method used Structural Equation Modelling (SEM) with Partial Least Square (PLS) Path Modelling with SmartPLS 3.0 anlysis tools. The result of this study were 1) Authentic Leadership had no effect on Strategic Management Accounting. 2) Organizational Learning had positive and significant effect on Strategic Management Accounting. 3) Technological innovation had positive and significant effect on Strategic Management Accounting. 4) Authentic Leadership had positive and significant effect on Company Performance. 5) Organizational Learning has positive and significant effect on Company Performance. 6) Technological Innovation had positive and significant effect on Company Performance. 7) Strategic Management Accounting had no effect on Company Performance. 8) Authentic Leadership had no effect on Company Performance through Strategic Management Accounting as an intervening variable. 9) Organizational Learning had no effect on Company Performance through Strategic Management Accounting as an intervening variable. 10) Technological Innovation had no effect on Company Performance through Strategic Management Accounting as an intervening variable
Biomarkers of Collagen Metabolism Are Associated with Left Ventricular Function and Prognosis in Dilated Cardiomyopathy: A Multi-Modal Study

Background: Collagen cross-linking is a fundamental process in dilated cardiomyopathy (DCM) and occurs when collagen deposition exceeds degradation, leading to impaired prognosis. This study investigated the associations of collagen-metabolism biomarkers with left ventricular function and prognosis in DCM. Methods: DCM patients who underwent endomyocardial biopsy, blood sampling, and cardiac MRI were included. The primary endpoint included death, heart failure hospitalization, or life-threatening arrhythmias, with a follow-up of 6 years (5–8). Results: In total, 209 DCM patients were included (aged 54 ± 13 years, 65% male). No associations were observed between collagen volume fraction, circulating carboxy-terminal propeptide of procollagen type-I (PICP), or collagen type I carboxy-terminal telopeptide [CITP] and matrix metalloproteinase [MMP]-1 ratio and cardiac function parameters. However, CITP:MMP-1 was significantly correlated with global longitudinal strain (GLS) in the total study sample (R = −0.40, p < 0.0001; lower CITP:MMP-1 ratio was associated with impaired GLS), with even stronger correlations in patients with LVEF > 40% (R = −0.70, p < 0.0001). Forty-seven (22%) patients reached the primary endpoint. Higher MMP-1 levels were associated with a worse outcome, even after adjustment for clinical and imaging predictors (1.026, 95% CI 1.002–1.051, p = 0.037), but CITP and CITP:MMP-1 were not. Combining MMP-1 and PICP improved the goodness-of-fit (LHR36.67, p = 0.004). Conclusion: The degree of myocardial cross-linking (CITP:MMP-1) is associated with myocardial longitudinal contraction, and MMP-1 is an independent predictor of outcome in DCM patients.
THE EFFECT OF TABURIA FORTIFICATION AND NUTRITION EDUCATION OF MOTHERS TO ON NUTRITIONAL STATUS OF 12-24 MONTHS OLD CHILDREN IN INDONESIA : RANDOMIZED CONTROLLED TRIAL STUDY

ABSTRACTBackground: Mother's nutritional knowledge and parents' feeding practices will influence children's eating behavior which have an impact on the child's growth.Objective: The purpose of this study was to determine the effects of Taburia fortification and nutrition education of mothers on the nutritional status of children in Waipare Public health center in East Nusa Tenggara.Materials and Methods: This study was a randomized controlled trial. A total of 180 mothers and their children aged 12-24 months who had malnourished (z-score -3 to -2). The group divided into teams were the intervention group (IG) (n=90) and the control group (CG) (n=90). The IG give intervention for three months. The mothers were given nutrition education, while their children were given taburia. The CG, mothers were given nutrition education. Data feeding rules obtained using a self-administered feeding practice-Questionnaire (FPQ). Dietary intake assessment of macronutrient and micronutrient three-day food records, nutritional status, and percentage of child's sick day was conducted before and after the intervention.Results: The result of the study showed that there was no significant difference in the mean increase (P> 0.01) between knowledge scores in IG and CG, post-intervention. Lower percentage of sickness among children in IG than CG. The average nutrient intake, WAZ (0.97±0.52), WLZ (1.02±0.42) of IG increased and was higher than CG after the intervention. The LAZ of IG increased (0.34±0.66 SD) while on the CG declined (0.27±0,31 SD). Conclusion: Thus, The Taburia fortification intervention was useful in improving WAZ, LAZ, WLZ in children who experienced malnutrition, but the intervention nutrition education of mothers can increase WAZ and WLZ.
Real-World Data about Commonly Used Antibiotics in Long-Term Care Homes in Australia from 2016 to 2019

In this study, we use real-world data to explore trends in antibiotic use in a dynamic cohort of long-term care (LTC) residents. A cross-sectional retrospective analysis of pharmacy medication supply records of 3459 LTC residents was conducted from 31 May 2016 to 31 May 2019. The primary outcome was the monthly prevalence of residents with an antibiotic episode. Secondary outcomes were the type of antibiotic used and duration of use. Over the three-year study period, residents were supplied 10460 antibiotics. On average, 18.9% of residents received an antibiotic monthly. Antibiotic use decreased slightly over time with a mean of 168/1000 (95% CI 146–177) residents using at least one antibiotic per month in June 2016 to 148/1000 (95% CI 127–156) in May 2019. The total number of antibiotic days per 100 resident days remained relatively constant over the study period: 8.8 days in 2016–2017, 8.4 in 2017–2018 and 6.4 in 2018–2019. Prolonged durations exceeding 100 days were seen for a small percentage of residents. We found extensive antibiotic use, which is a recognized contributor to antimicrobial resistance development, underscoring the necessity for quality treatment guidelines in this vulnerable population.
The Role of Quality of Work Life on Job Stress and Turnover Intention Mediated by Job Satisfaction of Private Teachers in Tangerang District

The purpose of the study was to explore the role of Quality of Work-life on Job Stress, Turnover intention mediated by job satisfaction. Referring to previous researchers' theory and empirical evidence, the authors collected the data by distributing questionnaires online to teachers teaching at private schools in the Tangerang district. Respondents were private teachers teaching at the elementary–high school level using purposive sampling methods. This research was a quantitative study with the Structural Equation Model (SEM) method. Some of the findings in this study were the first positive influence of Quality of Work Life, Job Satisfaction on Turnover intention. Second, the negative influence of Quality of Work Life, Job Satisfaction on turnover intention was insignificant, while there was no direct influence between Job Satisfaction, Job Stress, and Turnover intention. The managerial implication of research for Organizations is the increased quality of work life to improve the warm work environment. This will encourage positive change for teachers in particular and benefit the organization. Keywords— Job Satisfaction; Job Stress; Quality of Work Life; Turnover Intention
Penggunaan modul fisika terintegrasi nilai-nilai Alquran pada materi usaha dan energi untuk meningkatkan kemampuan pemecahan masalah peserta didik

Pendidikan harus menciptakan peserta didik yang berkualitas. Hakikatnya pada perkembangan teknologi ini kualitas tidak hanya dalam intelektual saja, tetapi dari segi sikap spiritual dan kemampuan yang dihasilkan. Kemampuan pemecahan masalah pada materi usaha dan energi masih perlu ditingkatkan dan penggunaan bahan ajar berupa modul di sekolah pun masih kurang. Penelitian ini bertujuan untuk mengetahui keterlaksanaan pembelajaran dan perbedaan kemampuan pemecahan masalah antara kelas eksperimen dan kontrol. Metode yang digunakan Quasi-Eksperimental Design dengan desain Nonequivalent Control Group. Sampel penelitian kelas X MIA 1 dan X MIA 2 dipilih dengan teknik purposive sampling. Hasil penelitian menunjukkan rata-rata peningkatan keterlaksanaan pembelajaran di kelas eksperimen setiap pertemuannya terkategori sangat baik dan di kelas kontrol terkategori baik. Berdasarkan nilai N-Gain pada kelas eksperimen dan kontrol sebesar 0,40 dan 0,30 menunjukkan terdapat peningkatan kemampuan pemecahan masalah terkategori sedang. Berdasarkan Uji Mann-Whitney di kelas eksperimen dan kontrol diperoleh Zhitung (-4,72) > Ztabel (0,5199) ketika pretest dan Zhitung (-5,319) > Ztabel (0,5199) ketika posttest. Hal ini menunjukkan terdapat perbedaan kemampuan pemecahan masalah peserta didik. Oleh karena itu, modul fisika terintegrasi nilai-nilai Alquran dapat dijadikan alternatif untuk meningkatkan kemampuan pemecahan masalah peserta didik pada materi usaha dan energi.
Technical analysis as a sentiment barometer and the cross-section of stock returns

This paper explores an unexamined sentiment channel through which technical analysis can add value. We use a spectrum of technical trading strategies to build a daily market sentiment indicator that is highly correlated with other commonly used sentiment measures. This technical-analysis-based sentiment indicator positively predicts near-term returns and is inversely related to long-term returns in the cross-section. Simple trading strategies based on this sentiment indicator yield substantial abnormal returns. These results are consistent with the explanation that lack of synchronization induces rational arbitrageurs to exploit the mispricing before it is corrected.
Global Transcriptome and Co-Expression Network Analyses Revealed Hub Genes Controlling Seed Size/Weight and/or Oil Content in Peanut

Cultivated peanut (Arachis hypogaea L.) is an important economic and oilseed crop worldwide, providing high-quality edible oil and high protein content. Seed size/weight and oil content are two important determinants of yield and quality in peanut breeding. To identify key regulators controlling these two traits, two peanut cultivars with contrasting phenotypes were compared to each other, one having a larger seed size and higher oil content (Zhonghua16, ZH16 for short), while the second cultivar had smaller-sized seeds and lower oil content (Zhonghua6, ZH6). Whole transcriptome analyses were performed on these two cultivars at four stages of seed development. The results showed that ~40% of the expressed genes were stage-specific in each cultivar during seed development, especially at the early stage of development. In addition, we identified a total of 5356 differentially expressed genes (DEGs) between ZH16 and ZH6 across four development stages. Weighted gene co-expression network analysis (WGCNA) based on DEGs revealed multiple hub genes with potential roles in seed size/weight and/or oil content. These hub genes were mainly involved in transcription factors (TFs), phytohormones, the ubiquitin–proteasome pathway, and fatty acid synthesis. Overall, the candidate genes and co-expression networks detected in this study could be a valuable resource for genetic breeding to improve seed yield and quality traits in peanut.
A History of Violence: The Impact of Early Violence Exposure on Financial Risk Preferences

This paper examines whether growing up in areas with high homicide rates affects financial risk preferences. Our key conjecture is that individuals who have grown up in violent areas possess more risk averse financial preferences. We find support for this hypothesis using a unique dataset of mutual fund investors from one of Colombia’s largest stock brokers alongside Colombian official data on homicide rates.
Running Out of Water

In March 1934, Benjamin Baker Moeur, then governor of the state of Arizona in the United States, became extremely agitated upon hearing that the neighboring state of California was preparing to build a dam on the Colorado River to deliver more water to growing cities in Southern California. The river, which in its lower reaches forms the border between California and Arizona, had recently shriveled to a fifth of its normal water flow after 5 years of parching drought across the western part of the country.
Human Rotavirus Replicates in Salivary Glands and Primes Immune Responses in Facial and Intestinal Lymphoid Tissues of Gnotobiotic Pigs

Human rotavirus (HRV) is a leading cause of viral gastroenteritis in children across the globe. The virus has long been established as a pathogen of the gastrointestinal tract, targeting small intestine epithelial cells and leading to diarrhea, nausea, and vomiting. Recently, this classical infection pathway was challenged by the findings that murine strains of rotavirus can infect the salivary glands of pups and dams and transmit via saliva from pups to dams during suckling. Here, we aimed to determine if HRV was also capable of infecting salivary glands and spreading in saliva using a gnotobiotic (Gn) pig model of HRV infection and disease. Gn pigs were orally inoculated with various strains of HRV, and virus shedding was monitored for several days post-inoculation. HRV was shed nasally and in feces in all inoculated pigs. Infectious HRV was detected in the saliva of four piglets. Structural and non-structural HRV proteins, as well as the HRV genome, were detected in the intestinal and facial tissues of inoculated pigs. The pigs developed high IgM antibody responses in serum and small intestinal contents at 10 days post-inoculation. Additionally, inoculated pigs had HRV-specific IgM antibody-secreting cells present in the ileum, tonsils, and facial lymphoid tissues. Taken together, these findings indicate that HRV can replicate in salivary tissues and prime immune responses in both intestinal and facial lymphoid tissues of Gn pigs.