Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive Exploration of M2 Macrophages and Its Related Genes for Predicting Clinical Outcomes and Drug Sensitivity in Lung Squamous Cell Carcinoma

Background M2 macrophages play an important role in cancers. However, the role of M2 macrophages has not been clarified in lung squamous cell carcinoma. Methods All the open-accessed data were downloaded from The Cancer Genome Atlas database. All the analysis was performed in the R software. The CIBERSORT algorithm was utilized to quantify the immune cell infiltration in the tumor microenvironment. LASSO regression and multivariate Cox regression analysis were carried out for the creation of the prognostic model. Pathway enrichment analysis was performed using the single sample Gene Set Enrichment Analysis (ssGSEA) and clueGO algorithm. Results In our study, we comprehensively explored the role of M2 macrophages and its related genes in LUSC patients. We found that the patients with high M2 macrophage infiltration tend to have a worse prognosis. Also, some oncogenetic pathways were activated in the patients with high M2 macrophage infiltration. Further, a prognosis model based on six M2 macrophage-related genes was established, including TRIM58, VIPR2, CTNNA3, KIAA0408, CLEC4G, and MATN4, which showed a good prognosis prediction efficiency in both training and validation cohort. Pathway enrichment analysis showed that the pathway of allograft rejection, bile acid metabolism, coagulation, inflammatory response, IL6/JAK/STAT3 signaling, hedgehog signaling, peroxisome, and myogenesis were significantly activated in the high-risk patients. Based on the results of an investigation of immune infiltration, risk score was found to have a positive correlation with M2 macrophages and resting CD4+ memory T cells, but a negative correlation with follicular helper T cells, M1 macrophages, and Tregs. In addition, we discovered that patients in high-risk groups may respond better to immunotherapy than individuals in lower-risk groups. However, low-risk patients might be more sensitive to cisplatin. Conclusions Our model is a powerful tool to predict LUSC patient prognosis and could indicate the sensitivity of immunotherapy and chemotherapy.
I Think I Can, I Think I Can: Effects of Entrepreneurship Orientation on Entrepreneurship Intention of Saudi Agriculture and Food Sciences Graduates

Entrepreneurship plays a significant role in achieving the national agenda and the development of nations. The leadership of the Kingdom of Saudi Arabia (KSA) pays significant attention to the role of entrepreneurship by supporting the Saudi Vision 2030 and its programs, e.g., the National Transformation Program and the Human Capability Development Program. The current research examines the effects of entrepreneurship orientation on entrepreneurship intentions among agriculture and food sciences graduates in KSA. More exactly, the research examines the interrelationship and effects of risk-taking, innovativeness, and pro-activeness on the entrepreneurship intentions of higher education graduates, especially among agriculture and food sciences graduates. It also examines the mediating effect of innovativeness and pro-activeness between entrepreneurship orientation and entrepreneurship intention. For this purpose, a pre-examined questionnaire was collected randomly from 440 graduates at several KSA universities. The results of structural equation modeling (SEM) supported all research hypotheses and confirmed a direct significant effect of risk-taking on the entrepreneurship intention of students and an indirect effect through innovativeness and pro-activeness. The results confirmed complimentary mediation of innovativeness and pro-activeness in the link between entrepreneurship orientation and entrepreneurship intention. The findings of the research offer some implications for scholars and policymakers in the Saudi context, which are discussed.
Does raising bank capital limit bank liquidity creation? Evidence from commercial banks in Vietnam

Little is known about the trade-off mechanism underlying raising bank capital and enhancing bank liquidity creation, as empirical evidence is sparse. Pursuing Basel II target capital seems challenging and costly because it could generate unintended consequences, such as reducing liquidity creation. Thus, the aim of this study is to point out that the pursuit of raising capital to meet Basel II standards in recent years has limited the liquidity creation function of banks. This finding is reliable and consistent across different research methods, i.e. least absolute shrinkage and selection operator (LASSO regression) and the simultaneous equations model (SEM). We chose Vietnam's banking system for this study because applying Basel II in Vietnam has been topical in recent years and also more challenging than in the rest of the world. Our finding strengthens academically the financial fragility-crowding out hypothesis developed by Diamond & Rajan (2000).
Antioxidant Activity of Hemp ( Cannabis sativa L.) Seed Oil in Drosophila melanogaster Larvae under Non-Stress and H 2 O 2 Induced Oxidative Stress Conditions potential including antioxidant, antitumor, anti-Citation:

: The oil extracted from hemp seeds has significant nutritional and biological properties due to the unique composition of polyunsaturated fatty acids and various antioxidant compounds. The potential of this oil for the prevention of oxidative stress and for the treatment of oxidative-stress-induced ailments is of increasing interest. Most studies of hemp seed oil were conducted in-vitro, meaning we lack information about effects and activity in vivo. In the present study, we evaluated the hypothesis that hemp seed oil at different concentrations improves the oxidative state of D. melanogaster , under non-stress as well as hydrogen-peroxide-induced stress. We analyzed the effects of hemp seed oil on oxidative stress markers and on the life cycle of D. melanogaster under non-stress and hydrogen-peroxide-induced stress conditions. D. melanogaster larvae were exposed to hemp seed oil concentrations ranging from 12.5 to 125 μL/mL. The results revealed that under non-stress conditions, oil concentrations up to 62.5 µL/mL did not induce negative effects on the life cycle of D. melanogaster and maintained the redox status of the larval cells at similar levels to the control level. Under oxidative stress conditions, biochemical parameters were significantly affected and only two oil concentrations, 18.7 and 31.2 µL/mL, provided protection against hydrogen peroxide stress effects. A higher oil concentration (125 μL/mL) exerted negative effects on the oxidative status and increased larval mortality. The tested oil was characterized chemically by NMR, transesterification, and silylation, followed by GC-MS analyses, and was shown to contain polyunsaturated fatty acid triglycerides and low levels of tocopherols. The high levels of linoleic and linolenic acids in the oil are suggested to be responsible for the observed in vivo antioxidant effects. Taken together, the results show that hemp seed oil is effective for reducing oxidative stress at the cellular level, thus supporting the hypothesis. The obtained results point to the potential of hemp seed oil for the prevention and treatment of conditions caused by the action of reactive oxygen species.
Li-Ion Conductive Li1.3Al0.3Ti1.7(PO4)3 (LATP) Solid Electrolyte Prepared by Cold Sintering Process with Various Sintering Additives

The density, microstructure, and ionic conductivity of solid electrolyte Li1.3Al0. 3Ti1.7(PO4)3 (LATP) ceramics prepared by cold sintering using liquid and solid sintering additives are studied. The effects of both liquid (water and water solutions of acetic acid and lithium hydroxide) and solid (lithium acetate) additives on densification are investigated. The properties of cold-sintered LATP are compared to those of conventionally sintered LATP. The materials cold-sintered at temperatures 140–280 °C and pressures 510–600 MPa show relative density in the range of 90–98% of LATP’s theoretical value, comparable or higher than the density of conventionally sintered ceramics. With the relative density of 94%, a total ionic conductivity of 1.26 × 10−5 S/cm (room temperature) is achieved by cold sintering at the temperature of 200 °C and uniaxial pressure of 510 MPa using water as additive. The lower ionic conductivities of the cold-sintered ceramics compared to those prepared by conventional sintering are attributed to the formation of amorphous secondary phases in the intergranular regions depending on the type of additives used and on the processing conditions selected.
INFLUENCE OF USING FOLIC ACID ON LACTATING ZARAIBI GOATS PERFORMANCE

Forty female Zaraibi goats (during the last month of pregnancy) in the 3 rd and 4 th sea7sons of lactation were used to study the effect of folic acid on milk production, some rumen and blood parameters and changes of live body weight of Zaraibi does. Forty does were divided randomly into four equal groups (10 females each). Animals in groups G1,G2 and G3 received 0, 2 and 6 mg folic acid/kg body weight(BW) daily, respectively in their diets. But, G4 received one intravenous injection of 4 ml saline solution containing 40 mg folic acid, weekly. Feeding allowances of Zaraibi does were calculate according to NRC (1981). The obtained results showed that using folic in Zaraibi does rations improved milk yield by 8.8, 11.6 and 22.1% forG2,G3 and G4, respectively compared with the co7ntrol(G1),and the improvement was significant with G4. However, milk composition was not significantly affected by folic acid. The results of rumen parameters of Zaraibi goats showed that pH value, ammonia-N and volatile fatty acids (VFA’s) were not significantly differed among the groups. Moreover, no remarkable effects of folic acid were observed on hemato-biochemical parameters. Feed utilization efficiency, based on DM, was better with G4 then followed by G3 and G2 compared with the control ration (G1). Accordingly, it could be concluded that using folic acid had positive role on improving milk yield for lactating Zaraibi goats without any adverse effect on milk composition as well as rumen and blood parameters. It improved also fee7d
Host Responses to Live-Attenuated ASFV (HLJ/18–7GD)

African swine fever (ASF) is a highly contagious and fatal disease caused by the African swine fever virus. Recently, the multigene family and CD2v gene-deleted ASF vaccine candidate HLJ/18-7GD was found to be safe and effective in laboratory and clinical trials. However, the immune-protective mechanisms underlying the effects of HLJ/18-7GD remain unclear. We assessed samples from pigs immunized with a single dose of 106 TCID50 HLJ/18-7GD. We found that pigs immunized with HLJ/18-7GD showed high levels of specific antibodies. T lymphocyte subsets (helper T cells (Th); cytotoxic T lymphocytes (CTL); double-positive T cells (DP-T cells)) were temporarily increased in peripheral blood mononuclear cells (PBMCs) after HLJ/18-7GD immunization. Once the HLJ/18-7GD-immunized pigs had been challenged with virulent HLJ/18, the percentage of Th, CTL, and DP-T cells increased significantly. PBMCs extracted from the pigs induced higher levels of CD8+ T cells after infection with the HLJ/18 strain in vitro. The levels of GM-CSF, IFN-γ, and TNF-α were upregulated at 7 days post-inoculation; this finding was contrary to the results obtained after HLJ/18 or HLJ/18ΔCD2v infection. The immune protection from HLJ/18-7GD resulted from many synergies, which could provide a theoretical basis for HLJ/18-7GD as a safe and effective ASF vaccine.
SCREENING FOR COLD TOLERANCE IN TOMATOES USING SOME PROMISING PHYSIOLOGICAL AND METABOLICAL BASIS.

Experiments were conducted during early summer seasons of 1996/97 and 1997/98 to screening for sold tolerance among different tomato genotypes, i.e. (MHX 668, MHX 4953, MHX 975, US, LX II, GR and Super Marmand) depending on some physiological and metabolical basis. The results could be summarized as follow:-All the studied genotypes were significantly varied in their morphological, physiological and metabolical behaviour under low temperature condition in open field. Genotypes arranged from the best to the worst in their dry matter, chlorophyll, total protein, soluble sugars and minerals as well as pollen grain weight and germination %, fruit setting and yield) and in reverse order dealing with I 1 and I 2 index of cold responses (tolerance or sensitive) as follows: MHX 668 - Lx 4 MHX 4953 - US - Super marmand.  GR and at least MHX 975, respectively. Fruit setting % and yield were significantly and positively correlated with all the studied parameters and negatively with I 1 and I 2 index. It was found that MHX 668 and LX II were significantly the best genotypes in growth, fruit setting and yield under stress condition due to their superior physiological and metabolical behaviour and function during their different stages of development. Herein it could be concluded that, those must be utilized in breeding programs for producing new cold tolerant tomato cvs or to be directly cultivated in early summer seasons. and I 1 (Ch 0 /Ch 1 ) index, I 2 (EC 1 /EC 2 ) lower an cold tolerance case, cold injury case). sugars, P, K and Ca) as well as pollen grain weight and germination percentage, all in higher values associated with cold tolerance.
Paramagnetic effects in vortex lattice field distribution in strongly type-II superconductors

We present an analysis of the magnetic field distribution in the Abrikosov lattice of high-$\kappa$ superconductors with singlet pairing in the case where the critical field is mainly determined by the Pauli limit and the superfluid currents partly come from the paramagnetic interaction of electron spins with the local magnetic field. The derivation is performed in the frame of the generalized Clem variational method which is valid not too close to the critical field and furthermore with the Abrikosov type theory in the vicinity of it. The found vortex lattice form factor increases with increasing field and then falls down at approach of the upper critical field where the superconducting state is suppressed.
School Satisfaction and Its Associations with Health and Behavioural Outcomes among 15-Years Old Adolescents

Background: Health and behavioural outcomes of adolescents have been shown to be related to school pressure, demands or unfavourable relationships with classmates or teachers. These associations may relate to school satisfaction, but evidence on this is lacking. Therefore, our aim is to explore the associations of school satisfaction with hopelessness, health complaints, fighting and truancy. Methods: Data come from the cross-sectional Health Behaviour in School-aged Children study collected in 2018 from Slovak 15-year-old adolescents (N = 816; 50.9% boys). School satisfaction was measured by school engagement and attitudes towards education, grouped as: satisfied (both positive), inconsistent (one positive, one negative) and indifferent (both negative). Hopelessness, health complaints, fighting and truancy were measured using self-report questionnaires. Logistic regression models were used to explore the associations of school satisfaction with hopelessness, health complaints, fighting and truancy separately. Results: Indifferent adolescents were more likely to feel hopeless, to frequently experience two or more health complaints, to be involved in a fight and to skip school (odds ratios/95%-confidence interval: 2.57/1.49–4.45; 2.51/1.48–4.25; 1.92/1.02–3.60; and 2.34/1.25–4.40, respectively) than satisfied adolescents. Inconsistent adolescents were more likely to frequently experience two or more health complaints than satisfied adolescents (1.72/1.05–5.79). Conclusions: School satisfaction affects adolescents’ health and social behaviour and may threaten their healthy development.
Spatial and temporal variation in δ13C values of methane emitted from a hemiboreal mire: methanogenesis, methanotrophy, and hysteresis

Abstract. The reasons for spatial and temporal variation in methane emission from mire ecosystems are not fully understood. Stable isotope signatures of the emitted methane can offer clues to the causes of these variations. We measured the methane emission (FCH4) and 13C signature (δ13C) of emitted methane by automated chambers at a hemiboreal mire for two growing seasons. In addition, we used ambient methane mixing ratios and δ13C to calculate a mire-scale 13C signature using a nocturnal boundary-layer accumulation approach. Microbial methanogenic and methanotrophic communities were determined by a captured metagenomics analysis. The chamber measurements showed large and systematic spatial variations in δ13C-CH4 of up to 15 ‰ but smaller and less systematic temporal variation. According to the spatial δ13C–FCH4 relations, methanotrophy was unlikely to be the dominating cause for the spatial variation. Instead, these were an indication of the substrate availability of methanogenesis being a major factor in explaining the spatial variation. Genetic analysis indicated that methanogenic communities at all sample locations were able to utilize both hydrogenotrophic and acetoclastic pathways and could thus adapt to changes in the available substrate. The temporal variation in FCH4 and δ13C over the growing seasons showed hysteresis-like behavior at high-emission locations, indicative of time-lagged responses to temperature and substrate availability. The upscaled chamber measurements and nocturnal boundary-layer accumulation measurements showed similar average δ13C values of −81.3 ‰ and −79.3 ‰, respectively, indicative of hydrogenotrophic methanogenesis at the mire. The close correspondence of the δ13C values obtained by the two methods lends confidence to the obtained mire-scale isotopic signature. This and other recently published data on δ13C values of CH4 emitted from northern mires are considerably lower than the values used in atmospheric inversion studies on methane sources, suggesting a need for revision of the model input.
Students’ Perceptions of Synchronous Online Learning using Google Meet in a Reading Class

The purpose of this research is to investigate the students’ perceptions of synchronous online learning using Google Meet. Synchronous online learning is applied to facilitate the students to acquire knowledge during this pandemic. However, the students’ perception of the synchronous online using Google Meet in a specific skill in ELT is still understudied. A qualitative case study was used to investigate this phenomenon. The participants of this study were 18 students in the first semester who were Electrical Engineering major. The participants were chosen purposively due to class participation and willingness. The data was gathered from the questionnaire and interviews. It was analyzed using the Interactive Model of Data Analysis. This study exposed that the students positively perceived implementing synchronous online learning using Google Meet in reading class. They pointed out that it could help the students read more and feel motivated to be active. It also aided to increase their reading by online discussion. However, they found some challenges which they perceived during synchronous online learning. The challenges came from environmental, technical, and personal problems. The implication of this study relates to continuing the teaching-learning process of synchronous online learning using Google Meet. It provides some benefits that support the teaching learning process. Then, the institution and the government should support and promote the effectiveness of synchronous online learning by improving their learning and providing the necessary learning infrastructure for all students.
Subjective Norms and Behavioral Control; Its Effectiveness On Interest in Sharia Insurance

This study aims to analyze (1) the effect of subjective norms on interest in sharia insurance at AXA Mandiri Sharia Bank, (2) the effect of behavioral control on interest in sharia insurance at AXA Mandiri Sharia Bank, and (3) the influence of subjective norms and behavioral control on interest in sharia insurance. at AXA Mandiri Sharia Bank. The object of this research is AXA Mandiri Syariah Insurance. Respondents who became the population of this study were AXA Mandiri Syariah Insurance customers, Serang City, Banten Province. The sample taken in this study amounted to 80 respondents. The research method used is quantitative. Methods of data collection using a questionnaire. Data were analyzed using the multiple linear regression method. The results of this study indicate that (1) subjective norms have a significant positive effect on interest in sharia insurance at AXA Mandiri Sharia Bank, (2) Behavioral control has a significant positive effect on interest in sharia insurance at AXA Mandiri Sharia Bank, and (3) subjective norms and behavioral control have a significant positive effect on interest in sharia insurance at AXA Mandiri Sharia Bank.
Correlation of Fibroblast Growth Factor 21 (FGF-21) with Fetal and Maternal Complications in Patients with Gestational Diabetes Mellitus

Background: In the second or third trimester of pregnancy, gestational diabetes mellitus (GDM) can be characterized as glucose intolerance that was not overt prior to gestation. It can have long-term health effects, even if most GDMs go away on their own after delivery. It involves a higher risk for mothers to develop cardiovascular problems or type 2 diabetes mellitus (T2DM), and the child's propensity for obesity, cardiovascular disease, or T2DM. In addition to the liver, other metabolically active tissues such as fat, skeletal muscle, and the pancreas express the hepatokine FGF-21. T2DM can be predicted by a high level of FGF-21. T2DM and GDM are thought to share comparable pathogenesis, but the link between FGF-21 and GDM remains vague. The aim of the study to assess the correlation of FGF-21 with fetal and maternal complications among cases who had GDM. Patients and methods: There were 50 women diagnosed with GDM at 24-28 weeks of gestation and 50 healthy women recruited from the Diabetes and Obstetrics outpatient clinic to participate in this case-control research. Results: GDM patients had greater concentrations of FGF-21 compared to control group (p-value <0.01). Fasting blood glucose, 2-hour postprandial glucose, and haemoglobin A1C all had a significant correlation with serum FGF-21 in our research. Moreover, serum FGF-21 was correlated with the incidence of maternal hypertension in the studied groups (p-value 0.011), while the correlation of FGF-21 with the incidence of fetal complications whether fetal macrosomia, respiratory distress, or neonatal hypoglycemia was not significant. Conclusion: : FGF-21 levels are elevated in patients with GDM. Pregnant women who had greater levels of FGF-21 in their blood were shown to have higher blood pressure readings in this study. Maternal and fetal outcomes should be better linked to FGF-21 levels during pregnancy through additional research.