Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of Volatile Markers of Colorectal Cancer from Tumor Tissues Using Volatilomic Approach

The human body releases numerous volatile organic compounds (VOCs) through tissues and various body fluids, including breath. These compounds form a specific chemical profile that may be used to detect the colorectal cancer CRC-related changes in human metabolism and thereby diagnose this type of cancer. The main goal of this study was to investigate the volatile signatures formed by VOCs released from the CRC tissue. For this purpose, headspace solid-phase microextraction gas chromatography-mass spectrometry was applied. In total, 163 compounds were detected. Both cancerous and non-cancerous tissues emitted 138 common VOCs. Ten volatiles (2-butanone; dodecane; benzaldehyde; pyridine; octane; 2-pentanone; toluene; p-xylene; n-pentane; 2-methyl-2-propanol) occurred in at least 90% of both types of samples; 1-propanol in cancer tissue (86% in normal one), acetone in normal tissue (82% in cancer one). Four compounds (1-propanol, pyridine, isoprene, methyl thiolacetate) were found to have increased emissions from cancer tissue, whereas eleven showed reduced release from this type of tissue (2-butanone; 2-pentanone; 2-methyl-2-propanol; ethyl acetate; 3-methyl-1-butanol; d-limonene; tetradecane; dodecanal; tridecane; 2-ethyl-1-hexanol; cyclohexanone). The outcomes of this study provide evidence that the VOCs signature of the CRC tissue is altered by the CRC. The volatile constituents of this distinct signature can be emitted through exhalation and serve as potential biomarkers for identifying the presence of CRC. Reliable identification of the VOCs associated with CRC is essential to guide and tune the development of advanced sensor technologies that can effectively and sensitively detect and quantify these markers.
Prognostic Factors for Resolution Delay of Lower Urinary Tract Symptoms in Patients with Prostate Cancer after Low-Dose-Rate Brachytherapy

Simple Summary Chronological changes in the overactive bladder symptom score (OABSS) and the time-to-resolution of the OABSS were evaluated in 237 patients with prostate cancer who underwent low-dose-rate brachytherapy (LDR-BT) with iodine-125. The patients were divided into two groups: the OABSS resolution group and the resolution delay group. The OABSS in both groups worsened at 3 months following operation and gradually recovered at 9 months; however, the OABSS in the resolution delay group tended to worsen again after that. In the multivariate analysis, preoperative OABSS and the change from baseline to maximal OABSS were associated with OABSS resolution. To the best of our knowledge, this is the first study to evaluate the delayed resolution of storage symptoms. Abstract Urinary storage symptoms after low-dose-rate brachytherapy (LDR-BT) with iodine-125 have been noted to be less likely to improve to baseline compared to voiding symptoms. This study aimed to evaluate the chronological changes in the overactive bladder symptom score (OABSS) and the time-to-resolution of OABSS in patients undergoing LDR-BT. Patients with prostate cancer who underwent LDR-BT at Gifu University Hospital were enrolled. The OABSS was evaluated before and after LDR-BT. Patients were divided into the OABSS resolution and resolution delay groups, and the association between OABSS resolution delay and clinicopathological covariates was evaluated. In total, 237 patients were enrolled in this study, with a median follow-up of 88.3 months. The OABSS in both groups worsened at 3 months following operation and gradually recovered at 9 months; however, the OABSS in the resolution delay group tended to worsen again after that. In the multivariate analysis, preoperative OABSS and the change from baseline to maximal OABSS were associated with OABSS resolution. To our knowledge, this is the first study to evaluate the delayed resolution of OABSS after LDR-BT in patients with prostate cancer. A low baseline OABSS and significant changes in the OABSS from baseline were independent predictors of delayed OABSS resolution.
Injury Rates at an NCAA Division I Institution After the COVID-19 Lockdown: A Descriptive Epidemiological Study

Background: The coronavirus 2019 (COVID-19) pandemic led to frequent schedule changes, abbreviated seasons, and disrupted training at all levels of organized sports. Purpose/Hypothesis: The purpose of this study was to investigate the epidemiology of sports-related injuries at a single National Collegiate Athletic Association (NCAA) Division I institution during the 2020 COVID lockdown season when compared with pre-COVID seasons. It was hypothesized that there would be an increase in the overall injury rate and an increase in the number of days missed because of injury during the 2020 season when compared with the previous seasons. Study Design: Descriptive epidemiology study. Methods: The injury surveillance database at a single NCAA Division I institution was queried for injuries that resulted in time loss (missed game or practice) for a student-athlete or for injuries that persisted >3 days. Injuries were categorized by anatomic area. Days unavailable because of injury were recorded as total days that a student-athlete was listed as “out of activity. ” Injury incidence and days unavailable, per 1000 athlete-exposures (AEs), were calculated for 3 pre-COVID seasons (2017-2019) and the 2020 season. The authors calculated the injury rate ratio (IRR) and its associated 95% CI of the 2020 season in comparison with those for the pre-COVID seasons. Results: Compared with the pre-COVID seasons, the total injury incidence increased by 10.5% in the 2020 season (68.45 vs 75.65 injuries/1000 AEs; IRR, 1.11 [95% CI, 1.08-1.13]). Total days unavailable decreased by 20.7% in the 2020 season (1374 vs 1089 days/1000 AEs; IRR, 0.79 [95% CI, 0.77-2.26]). Compared with women’s teams, men’s teams had a larger increase in total injury incidence (16.4% vs 6.5%) and larger decrease in days unavailable (23.7% vs 10.75%). There were no clear trends to changes in anatomic distribution of injuries, either by sport or between the sexes. Conclusion: Compared with the pre-COVID seasons, the injury incidence was higher and the number of days missed because of injury lower among collegiate student-athletes at a single NCAA Division I school in the season immediately after the COVID-19 lockdown.
Factors Related to Stunting Incidence in Toddlers in the Working Area of the Waborobo Health Center, Betoambari District, Baubau City in 2023

Stunting in children is the impact of nutritional deficiencies during the first thousand days of life. This causes irreversible disturbance of the child's physical development, thus causing a decrease in cognitive and motor skills and a decrease in work performance. The purpose of this study was to determine the factors associated with stunting in toddlers in the work area of the Waborobo Health Center, Betoambari District, BauBau City in 2023. The type of research used in this study was an analytic survey study by taking non-random cluster sampling using a cross-sectional study design. by using the chi-square test in the SPSS program. The population in this study was 136 people, while the sample was 99 people. The results of this study found that there was a significant relationship between energy intake (P Value = 0.011 <0.05), protein intake (P Value = 0.007 <0.05), calcium intake (P Value = 0.001 <0.05), and administration Exclusive breastfeeding (P Value = 0.001 <0.05) with stunting. The conclusions of this study show that there is a significant relationship between energy intake, protein intake, calcium intake, and exclusive breastfeeding with the incidence of stunting in toddlers in the work area of the Waborobo Health Center, Betoambari District, BauBau City in 2023. The research suggestion is that the puskesmas needs to provide personal education to pregnant women and mothers with toddlers regarding the importance of nutritional intake during pregnancy and the toddler's growth period, as well as providing education regarding the nutritional status of toddlers, especially stunting, to the community or cadres.
Surgical Morbidity of Laparoscopic Hysterectomy versus Abdominal Hysterectomy: A Retrospective Overview

Objectives: Laparoscopic skills are not an innate behavior, nor can they be easily mimicked, and can only be acquired through hands-on training. The need for reliable training and its assessment is becoming increasingly important with the course of time. Materials and Methods: A retrospective comparative study was done in a tertiary care center where all patients undergoing hysterectomy by laparoscopic and abdominal route were included in the study. Objectives: Our study aims to compare the operative and postoperative complications of laparoscopic hysterectomy with abdominal hysterectomy. The study was conducted from June 2016 to October 2022. Results: The mean operative time for uteri size lesser than 12 weeks was found significant in the total laparoscopic hysterectomy (TLH) group (75 ± 25 min) to total abdominal hysterectomy (TAH) (117 ± 28 min, P < 0.001). The mean blood loss in the TLH group was significant (110 ± 30 ml vs. 160 ± 116 ml, P < 0.002). The mean hospital stay was significantly shorter in TLH (4 ± 2.4 days vs. 7 ± 2.41 days, P < 0.002). The operative and postoperative complications observed were 3.1% in the TLH group and 11.7% in the TAH group. Conclusion: TLH when performed efficiently has proved to be a preferable route over other conventional hysterectomies.
Ieee Transactions on Communications, Accepted Forpublication 1 Gallager's Exponent Analysis of Stbc Mimo Systems over Η-μ and Κ-μ Fading Channels

—In this paper, we analytically investigate Gallager's exponent for space-time block codes over multiple-input multiple-output block-fading channels with Gaussian input distribution. As a suitable metric of the fundamental tradeoff between communication reliability and information rate, Gallager's exponent can be used to determine the required codeword length to achieve a prescribed error probability at a given rate below the channel capacity. We assume that the receiver has full channel state information (CSI), while the transmitter has no CSI and performs equal power allocation across all transmit antennas. In the following , novel exact expressions for Gallager's exponent are derived for two well-known channel fading models, namely η-μ and κ-μ fading models. More importantly, the implications of fading parameters and channel coherence time on Gallager's exponent are investigated. In addition, we present new expressions for the Shannon capacity, cutoff rate and expurgated exponent for the above mentioned fading models, while in the high signal-to-noise ratio regime, simplified closed-form expressions are also derived. Finally, we highlight the fact that the presented analysis encompasses all previously known results on Nakagami-m, Rician, Rayleigh and Hoyt fading channels, as special cases.
Wear Analysis of 3D-Printed Spur and Herringbone Gears Used in Automated Retail Kiosks Based on Computer Vision and Statistical Methods

This paper focuses on a wear evaluation conducted for prototype spur and herringbone gears made from PET-G filament using additive manufacturing. The main objective of this study is to verify if 3D-printed gears can be considered a reliable choice for long-term exploitation in selected mechanical systems, specifically automated retail kiosks. For this reason, two methods were applied, utilizing: (1) vision-based inspection of the gears’ cross-sectional geometry and (2) the statistical characterization of the selected kinematic parameters and torques generated by drives. The former method involves destructive testing and allows for identification of the gears’ operation-induced geometric shape evolution, whereas the latter method focuses on searching for nondestructive kinematic and torque-based indicators, which allow tracking of the wear. The novel contribution presented in this paper is the conceptual and experimental application of the identification of the changes of 3D-printed parts’ geometric properties resulting from wear. The inspected exploited and non-exploited 3D-printed parts underwent encasing in resin and a curing process, followed by cutting in a specific plane to reveal the desired shapes, before finally being subjected to a vision-based geometric characterization. The authors have experimentally demonstrated, in real industrial conditions, on batch production parts, the usefulness of the presented destructive testing technique providing valid indices for wear identification.
Efficacy and safety of Dexmedetomidine for prevention of withdrawal syndrome in Pediatric Intensive Care Unit: protocol for an adaptive, multicenter, randomized, double blind, placebo-controlled, non-profit clinical trial

Background: Prolonged treatment with analgesic and sedative drugs in Pediatric Intensive Care Unit (PICU) may lead to undesirable effects as dependence and tolerance. Moreover, during the analgosedation weaning patients may develop clinical signs of withdrawal, known as withdrawal syndrome (WS). Some studies indicated that dexmedetomidine, a selective α2-adrenoceptors agonist, may be useful to prevent WS, but no clear evidences support this data. Aims of the present study are to evaluate the efficacy of dexmedetomidine in reducing the occurrence of WS during the analgosedation weaning, and to clearly assess its safety. Methods: We will perform an adaptive, multicenter, randomized, double-blind, placebo-controlled trial. Patients <18 years receiving a continuous intravenous analgosedation treatment for at least 5 days and presenting with clinical conditions that allows the analgosedation weaning will be randomly assigned to treatment A (dexmedetomidine) or treatment B (placebo). The treatment will be started 24 hours before the analgosedation-weaning at 0.4 mcg/kg/h, increased of 0.2 mcg/kg/h per hour up to 0.8 mcg/Kg/h (neonate: 0.2 mcg/Kg/h, increased of 0.1 mcg/Kg/h per hour up to 0.4 mcg/Kg/h)and continued throughout the whole weaning-time. The primary endpoint is the efficacy of the treatment, defined by the reduction in WS rate among patients treated with dexmedetomidine comparing with patients treated with placebo. Safety will be assessed collecting any potentially-related adverse event. The sample size assuring a power of 90% is 77 patients for each group (N total=154 patients). The study was approved by the Ethics Committee of the University-Hospital S.Orsola-Malpighi of Bologna on 22 March 2017. Discussion: The present trial will allow to clearly assess the efficacy of dexmedetomidine in reducing the occurrence of WS during the weaning of analgosedation drugs. In addition, the study will provide a unique insight into the safety profile of dexmedetomidine.
Evaluation and comparison of the efficacy of autologous fibrin glue with 4-0 silk sutures in periodontal flap closure and wound healing - A split mouth randomized controlled trial

Background Fibrin glue has shown to be a pioneering remedy to overcome the inconvenience of suturing. Autologous products reduce the risk of contamination and immunological responses compared to commercial fibrin glue. Hence using autologous fibrin glue (AFG) as a tissue sealant in periodontal flap closure would be of added value for a predictable outcome. Objective To evaluate and compare the efficacy of AFG with 4-0 silk sutures in periodontal flap closure and healing. Material and methods Total of 17 patients diagnosed with generalized periodontitis in the age group of 18 to 60 years with probing pocket depth of ≥ 6 mm and clinical attachment level of ≥5 mm in at least two quadrants were categorized into test group (AFG) and control group (4-0 silk sutures). Primary outcome measures [modified gingival index (MGI), early wound index (EHI) and interleukin 1 beta (IL-1ß) and secondary outcome measures (oral hygiene index, plaque index and visual analog scale (VAS) were recorded at baseline, 1, 2, 3 and 4 weeks. Results A statistically significant reduction of IL-1ß value (p =.005); MGI (p = .02); EHI (p = .004), VAS scores (p < .001) and a positive Spearman's correlation (rho = 0.15) was seen between EHI scores & IL-1ß levels in test group at 1week period in comparison to control group. Conclusion AFG showed promising results as an alternative to sutures. The use of AFG significantly improved clinical parameters and reduced the levels of pro-inflammatory cytokines making it an effective adhesive with healing properties in the era of suture-less periodontal flap surgery.
Stratosphere‐Troposphere Coupling of Extreme Stratospheric Wave Activity in CMIP6 Models

Extreme stratospheric wave activity has been suggested to be connected to surface temperature anomalies, but some key processes are not well understood. Using observations, we show that the stratospheric events featuring weaker‐than‐normal wave activity are associated with increased North American (NA) cold extreme risks before and near the event onset, accompanied by less frequent atmospheric river (AR) events on the west coast of the United States. Strong stratospheric wave events, on the other hand, exhibit a tropospheric weather regime transition. They are preceded by NA warm anomalies and increased AR frequency over the west coast, followed by increased risks of NA cold extremes and north‐shifted ARs over the Atlantic. Moreover, these links between the stratosphere and troposphere are attributed to the vertical structure of wave coupling. Weak wave events show a wave structure of westward tilt with increasing altitudes, while strong wave events feature a shift from westward tilt to eastward tilt during their life cycle. This wave phase shift indicates vertical wave coupling and likely regional planetary wave reflection. Further examinations of CMIP6 models show that models with a degraded representation of stratospheric wave structure exhibit biases in the troposphere during strong wave events. Specifically, models with a stratospheric ridge weaker than the reanalysis exhibit a weaker tropospheric signal. Our findings suggest that the vertical coupling of extreme stratospheric wave activity should be evaluated in the model representation of stratosphere‐troposphere coupling.
Initial morphologic evolution of Perdido Key berm nourishment, Florida

Abstract : This Coastal and Hydraulics Engineering Technical Note (CHETN) documents the initial morphologic evolution of the Perdido Key, FL, swash-zone berm based on beach-nearshore profile, sediment samples, and nearshore wave data collected during the first six months after berm construction. The US Army Corps of Engineers (USACE), Mobile District, dredged the navigation channel at Pensacola Pass, FL, from November 2011 to January 2012 and placed the 520,000 cubic yards (yd3) of dredged sand as a swash-zone berm nearshore of Perdido Key, FL. Beach quality sands are a valuable resource within the coastal zone in maintaining regional sediment balance. Compared to a typical beach fill (or direct beach placement), nearshore berm placement (in this case a swash-zone berm) has advantages of being less costly with more lenient regulatory restrictions on sediment type and monitoring requirements (Hands and Allison 1991; McLellan and Kraus 1991). The Perdido Key berm was designed to be an active berm that would quickly mobilize sediments in the energetic swash zone. The goal was to beneficially use maintenance dredged material to nourish the littoral environment adjacent to Pensacola Pass, and to have an immediate impact on the narrow subaerial beach. This CHETN documents the initial morphological evolution of the Perdido Key swash-zone berm placement based on analysis of beach-nearshore profiles, sediment samples, and nearshore wave data. The eastern portion of Perdido Key, including the present study area, was nourished in 1985 and 1989 (Dean et al. 1995). The 1985 beach nourishment was constructed to a berm height of +10.3 ft NAVD88, whereas the 1989 beach nourishment had a constructed berm height of +4.3 ft NAVD88 (Dean et al. 1995; Browder and Dean 2000). The 1989 nourishment also included a nearshore berm placed at roughly -22 ft NAVD88 with a crest height of roughly 5.7 ft. The 2012 Perdido Key artificial berm was placed west of Pensacola Pass (Figure 1).
Intracellular Amyloid Formation in Muscle Cells of A β-Transgenic Caenorhabditis Elegans : Determinants and Physiological Role in Copper Detoxification

Background: The amyloid β-peptide is a ubiquitous peptide, which is prone to aggregate forming soluble toxic oligomers and insoluble less-toxic aggregates. The intrinsic and external/ environmental factors that determine Aβ aggregation in vivo are poorly understood, as well as the cellular meaning of this process itself. Genetic data as well as cell biological and biochemical evidence strongly support the hypothesis that Aβ is a major player in the onset and development of Alzheimer's disease. In addition, it is also known that Aβ is involved in Inclusion Body Myositis, a common myopathy of the elderly in which the peptide accumulates intracellularly. Results: In the present work, we found that intracellular Aβ aggregation in muscle cells of Caenorhabditis elegans overexpressing Aβ peptide is affected by two single amino acid substitutions, E22G (Arctic) and V18A (NIC). Both variations show decrease intracellular amyloidogenesis compared to wild type Aβ. We show that intracellular amyloid aggregation of wild type Aβ is accelerated by Cu2+ and diminished by copper chelators. Moreover, we demonstrate through toxicity and behavioral assays that Aβ-transgenic worms display a higher tolerance to Cu2+ toxic effects and that this resistance may be linked to the formation of amyloid aggregates. Conclusion: Our data show that intracellular Aβ amyloid aggregates may trap excess of free Cu2+ buffering its cytotoxic effects and that accelerated intracellular Aβ aggregation may be part of a cell protective mechanism. Published: 6 January 2009 Molecular Neurodegeneration 2009, 4:2 doi:10.1186/1750-1326-4-2 Received: 4 September 2008 Accepted: 6 January 2009 This article is available from: http://www.molecularneurodegeneration. com/content/4/1/2 © 2009 Minniti et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.