Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduction of Pesticide Toxicity Under Field‐Relevant Conditions? The Interaction of Titanium Dioxide Nanoparticles, Ultraviolet, and Natural Organic Matter

In surface waters, the illumination of photoactive engineered nanomaterials (ENMs) with ultraviolet (UV) light triggers the formation of reactive intermediates, consequently altering the ecotoxicological potential of co‐occurring organic micropollutants including pesticides due to catalytic degradation. Simultaneously, omnipresent natural organic matter (NOM) adsorbs onto ENM surfaces, altering the ENM surface properties. Also, NOM absorbs light, reducing the photo(cata)lytic transformation of pesticides. Interactions between these environmental factors impact 1) directly the ecotoxicity of photoactive ENMs, and 2) indirectly the degradation of pesticides. We assessed the impact of field‐relevant UV radiation (up to 2.6 W UVA/m²), NOM (4 mg TOC/L), and photoactive ENM (nTiO2, 50 µg/L) on the acute toxicity of 6 pesticides in Daphnia magna. We selected azoxystrobin, dimethoate, malathion, parathion, permethrin, and pirimicarb because of their varying photo‐ and hydrolytic stabilities. Increasing UVA alone partially reduced pesticide toxicity, seemingly due to enhanced degradation. Even at 50 µg/L, nano‐sized titanium dioxide (nTiO2) reduced but also increased pesticide toxicity (depending on the applied pesticide), which is attributable to 1) more efficient degradation and potentially 2) photocatalytically induced formation of toxic by‐products. Natural organic matter 1) partially reduced pesticide toxicity, not evidently accompanied by enhanced pesticide degradation, but also 2) inhibited pesticide degradation, effectively increasing the pesticide toxicity. Predicting the ecotoxicological potential of pesticides based on their interaction with UV light or interaction with NOM was hardly possible, which was even more difficult in the presence of nTiO2. Environ Toxicol Chem 2020;39:2237–2246. © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Does Using Social Media Jeopardize Well-Being? The Importance of Separating Within- From Between-Person Effects

Social networking sites (SNS) are frequently criticized as a driving force behind rising depression rates. Yet empirical studies exploring the associations between SNS use and well-being have been predominantly cross-sectional, while the few existing longitudinal studies provided mixed results. We examined prospective associations between SNS use and multiple indicators of well-being in a nationally representative sample of Dutch adults (N ∼ 10,000), comprising six waves of annual measures of SNS use and well-being. We used an analytic method that estimated prospective effects of SNS use and well-being while also estimating time-invariant between-person associations between these variables. Between individuals, SNS use was associated with lower well-being. However, within individuals, year-to-year changes in SNS use were not prospectively associated with changes in well-being (or vice versa). Overall, our analyses suggest that the conclusions about the causal impact of social media on rising mental health problems in the population might be premature.
Factors Affecting Suicide Attempters Visiting Emergency Departments: Through a Focus on Acquired Capability with Rehearsal for Suicide, Negative Urgency, and Social Support

three variables–perceived burdensomeness, This study examines how acquired capability for suicide, negative urgency, and social support effectuate a suicide attempt. Sixty-three adults having visited an emergency room due to a suicide attempt were studied. The results can be summarized as follows. First, there were no significant sex differences in acquired capability for suicide, negative urgency, and social support. Second, the correlation among suicidal ideation, acquired capability for suicide, negative urgency, social support, and suicide attempts was examined. Results showed that suicide attempts were significantly and positively correlated with suicide ideation, acquired capability for suicide, and negative urgency. However, social support and suicide attempts did not significantly correlate. Third, results of hierarchical regression analysis indicated that acquired capability for suicide and negative urgency significantly predicted suicide attempts even when suicide ideation was controlled, but social support did not significantly explain attempts. In other words, study results imply that suicide attempts increase when acquired capability for suicide and negative urgency are high. Study results offer empirical data for understanding the intrinsic characteristics of individuals attempting suicide.
Methods for training collaborative biostatisticians

Abstract The emphasis on team science in clinical and translational research increases the importance of collaborative biostatisticians (CBs) in healthcare. Adequate training and development of CBs ensure appropriate conduct of robust and meaningful research and, therefore, should be considered as a high-priority focus for biostatistics groups. Comprehensive training enhances clinical and translational research by facilitating more productive and efficient collaborations. While many graduate programs in Biostatistics and Epidemiology include training in research collaboration, it is often limited in scope and duration. Therefore, additional training is often required once a CB is hired into a full-time position. This article presents a comprehensive CB training strategy that can be adapted to any collaborative biostatistics group. This strategy follows a roadmap of the biostatistics collaboration process, which is also presented. A TIE approach (Teach the necessary skills, monitor the Implementation of these skills, and Evaluate the proficiency of these skills) was developed to support the adoption of key principles. The training strategy also incorporates a “train the trainer” approach to enable CBs who have successfully completed training to train new staff or faculty.
Cryptococcosis in Hematopoietic Stem Cell Transplant Recipients: A Rare Presentation Warranting Recognition

Cryptococcosis, a life-threatening mycosis caused mainly by Cryptococcus neoformans, appears to be distinctly rare in hematopoietic stem cell transplant (HSCT) recipients. When it occurs, this fungal infection is a major limitation for a successful transplant. This review comprehensively analyses 24 cases, reported in the literature, of patients with haematological malignancies including leukemias, multiple myeloma, and lymphomas, as indication for HSCT, who presented with cryptococcosis after transplantation. Of the 24 cases, 11 each occurred in patients receiving allogeneic and autologous stem cell transplants, from bone marrow, peripheral blood, and umbilical cord blood. HSCT recipients were slightly more often male, and the age of the patients ranged from 12 to 74 years. Antifungal prophylaxis was reported in most cases. Clinical manifestations of cryptococcal disease included more frequently central nervous system involvement followed by fungaemia, disseminated infection, pulmonary cryptococcosis, cerebellitis, and diarrhea. Diagnosis differed depending on the clinical presentation but habitually included cryptococcal antigen assay, India ink, and culture. Notably, not only C. neoformans but also C. albidus, C. terreus, C. laurentii, and C. adeliensis were identified as the causal species, the last two including strains resistant to fluconazole. Amphotericin B, alone or in combination, was the most common antifungal drug used for the treatment of cryptococcosis in HSCT recipients. Due to the small number of cases, it was not possible to establish if mortality rate, which was the same as survival rate, depends on the effect of the immunosuppressive regimen, the site of cryptococcal infection, and/or the antifungal therapy used to control the mycosis. Although uncommon, the recognition of cryptococcal disease in stem cell transplant is essential for a timely and adequate treatment, improved prognosis, reduced morbidity and mortality, and successful transplantation.
In-vitro Labelling of Ovine Adipose-Derived Mesenchymal Stem Cells (oADMSCs) and Tracking Using MRI Technique

Abstract To understand the mechanisms standing behind a successful stem cell-based therapy, the monitoring of transplanted cell’s migration, homing as well as the engraftment efficiency and functional capability in-vivo has become a critical issue. The present study was designed to track the labelled oADMSCs in-vitro and its visualization through MRI technique. oADMSCs from passage 4 (P-4) to passage 6 (P-6) were labelled with superparamagnetic iron oxide (SPIO) conjugated with rhodamine (Molday Ion Rhodamine-B - MIRB) at the concentration of 25μg Fe/ml in DMEM. Internalized MIRB was observed under fluorescent microscope after 72 hrs of incubation. Labelled oADMSCs showed Prussian Blue positive reaction demonstrating the iron uptake of the cells. The viability of the MIRB-labelled oADMSCs ranged between 98-99 per cent and Trypan blue exclusion test showed no significant difference in viability between labelled and unlabelled oADMSCs. MR signal in control group of cells was similar to that of water. MR signals or fluorescence in MIRB-labelled cells decreased with increasing concentrations of iron. The T2 weighted images of MIRB-labelled oADMSCs increased with increasing concentrations of SPIOs. The MIRB was found to be nontoxic, and did not affect proliferation capacity in-vitro.
LIPID AND LIPOPROTEIN LEVELS IN HIV-INFECTED ADULTS WITH SEPSIS COMPARED TO HEALTHY HIV- INFECTED CONTROLS

Background: In acute sepsis, reduced lipid and lipoprotein levels occur in HIV negative patients, in particular, low high-density lipoprotein cholesterol (HDL–c) levels are inversely correlated with sepsis severity and increased mortality. However, due to the limited data describing lipid and lipoprotein levels in septic HIV–infected individuals we aimed to investigate the changes in this subgroup. Materials and Methods: A prospective cross–sectional observational study of HIV–infected patients comparing admitted HIV – infected patients with sepsis to healthy controls from the antiretroviral therapy (ART) clinic. Non fasting - lipograms, ART use, diagnosis of tuberculosis (TB), markers of infection, renal function and mortality outcome to 3 months post discharge were reviewed. Results: Total cholesterol (TC), low–density lipoprotein (LDL–c) and HDL-c were all significantly lower in the sepsis group (p < 0.001). HDL–c was significantly associated with a higher white cell count (p = 0.018), higher C– reactive protein (p = 0.036) and low serum albumin (p < 0.001). In those with active TB (55%) HDL–c was reduced even further (0.55 vs. 0.72mmol/L, p = 0.013). Acute kidney injury (p = 0.560) and mortality at discharge (p = 0.097) or 3 months follow up (p = 0.953) was not associated with reduced HDL–c. Conclusion: Septic HIV–infected patients had significantly reduced lipid and lipoprotein levels at admission. Of note however, a low HDL–c was associated with markers of infection and reductions in HDL–c was more marked in those with active TB.
Flame Boundary Measurement Using an Electrostatic Sensor Array

The flame boundary is an important geometrical characteristic for the evaluation of flame properties such as heat release rate and radiation. Reliable and accurate measurement of the flame boundary is desirable for the prediction of flame structure and the optimization of combustion systems. Such measurement will inform the designers and operators of the combustion systems. This article presents for the first time a study of using an electrostatic sensor array for flame boundary measurement. The electrostatic sensor is placed in the vicinity of the flame to sense its movement through charge transfer. The principle, design, implementation, and assessment of a measurement system based on this methodology are introduced. Comparative experimental investigations with a digital camera conducted on a laboratory-scale combustion test rig show that the electrostatic sensor can respond to the variation of the distance between the electrode and the flame boundary. Reconstruction of the flame boundary is achieved using a set of distance measurements obtained from a sensor array. For diffusion flames over the range of fuel flow rate 0.60–0.80 L/min and premixed flames over the range of equivalence ratio 1.27–3.81, experimental results show that the measurement system is capable of providing a reliable measurement of the flame boundary. The correlation coefficients under all test conditions are mostly larger than 0.96, the mean relative errors within 7.4%, and the relative root-mean-square errors within 0.09. More accurate flame boundary measurements are achieved for diffusion flames. In addition, the overall polarity of charges in a flame can be determined from the polarity of the sensor signal.
Methodology for experimental and observational animal studies in cow-calf contact systems

Abstract In this Research Reflection we describe a common standpoint on suitable methodology for controlled and observational studies in cow-calf contact systems in dairy production. Different methods to assess behaviour, health and production in cow-calf contact systems are outlined. Knowledge and experience from researchers working in this field supplement scientific literature whenever relevant. Specific methods including study design, early behaviour of cow and calf, social behaviour relevant to cow-calf contact systems, human-animal relationships and aspects related to management (milking, weaning and separation, health) are reviewed, and recommendations formed. We expect that this paper can contribute to a better understanding of the complexity of cow-calf contact systems and help to advance research in this area of dairy production.
Growth, Productivity and Profitability of Fodder Sorghum and Cluster Bean as Influenced by Mixed Cropping and Nutrient Management

Background: The year round green forage supply for better health and productivity of the animals can be ensured by mixed cropping of cereal and legume forages along with proper nutrient management. Keeping these facts in mind an experiment was carried out to analyse growth, productivity and profitability of fodder sorghum and clusterbean as influenced by mixed cropping and nutrient management. Methods: Experiment was laid out in factorial randomized complete block design with four seed rate combinations of sorghum and clusterbean (S1 - sole sorghum, S2 - sole clusterbean, S3 - 75% sorghum + 25% clusterbean and S4 - 60% sorghum + 40% clusterbean) along with six nutrient management treatments (N1 - 100% RDF, N2 - 100% RDF + PGPR, N3 - 100% RDF + seaweed extract, N4 - 75% RDF + PGPR, N5 - 75% RDF + seaweed extract and N6 – 50% RDF + PGPR + seaweed extract) in three replications. The growth of crops was evaluated in terms of plant height, leaf length, leaf width, number of leaves, leaf stem ratio and stem girth which all together contributed towards the fodder yield. Results: In sorghum crop the growth was not statistically different between the treatments S1 and S3 but in clusterbean sole crop recorded higher growth yet the influence was not significant on all parameters. Among nutrient management N1, N2 and N3 treatments recorded higher growth and thus yield in both crops which was not statistically different from N5 treatment. The correlation study indicated that cumulative influence of these growth parameters resulted in higher green and dry fodder yield under sole crop. Whereas in mixed cropping S3 treatment recorded significantly at par fodder yield to S1. The evidence presented above shows that 75% sorghum + 25% clusterbean mixed cropping treatment with 75% RDF + seaweed extract served its purpose of fodder yield enhancement.
Developing a Cloud Scheme With Prognostic Cloud Fraction and Two Moment Microphysics for ECHAM‐HAM

We present a new cloud scheme for the ECHAM‐HAM global climate model (GCM) that includes prognostic cloud fraction and allows for subsaturation and supersaturation with respect to ice separately in the cloud‐free and cloudy air. Stratiform clouds form by convective detrainment, turbulent vertical diffusion, and large‐scale ascent. For each process, the corresponding cloud fraction is calculated, and the individual updraft velocities are used to determine cloud droplet/ice crystal number concentrations. Further, convective condensate is always detrained as supercooled cloud droplets at mixed‐phase temperatures (between 235 and 273 K), and convectively detrained ice crystal number concentrations are calculated based on the updraft velocity. Finally, the new scheme explicitly calculates condensation/evaporation and deposition/sublimation rates for phase‐change calculations. The new cloud scheme simulates a reasonable present‐day climate, reduces the previously overestimated cirrus cloud fraction, and in general improves the simulation of ice clouds. The model simulates the observed in‐cloud supersaturation for cirrus clouds, and it allows for a better representation of the tropical to extra‐tropical ratio of the longwave cloud radiative effect. Further, the ice water path, the ice crystal number concentrations, and the supercooled liquid fractions in mixed‐phase clouds agree better with observations in the new model than in the reference model. Ice crystal formation is dominated by the liquid‐origin processes of convective detrainment and homogeneous freezing of cloud droplets. The simulated ice clouds strongly depend on model tuning choices, in particular, the enhancement of the aggregation rate of ice crystals.
The Indirect Impact of Profitability on Firm Value: Evidence Dividend Policy as Moderators and Capital Structure as Mediator

Firm value is a basis for investors in deciding whether or not to invest in a firm. Therefore, a study on issuer’s strategies to maximize firm value requires special attention, especially in dealing with the Islamic capital market which is growing rapidly from time to time. A particular study is important to be conducted to look at the factors that have a direct or indirect effect on a firm's value, which includes; profitability, capital structure, and dividend policy. The path analysis approach is employed in the current study to reveal the effect of profitability on firm value, both directly and indirectly, with the intermediaries of capital structure and dividend policy. The results of the analysis indicate that profitability has a direct positive and significant effect on firm value and a negative and significant effect on capital structure, while the capital structure has a negative and insignificant effect on firm value. Indirectly, dividend policy moderates and strengthens the effect of profitability on firm value, but on the other hand, the capital structure does not mediate the effect of profitability on firm value. The absence of capital structure role in mediating the relationship between profitability and the firm value indicates that investors can determine the value of the firm directly by simply looking at the level of profitability, regardless of management’s strategy in arranging the capital structure.
Anxiety and Depression in Patients With Retinitis Pigmentosa

Purpose: Retinitis pigmentosa (RP) is a chronic progressive disease with no curative treatments. Understanding the variables involved with improving patients’ quality of life is important in managing this population. The literature investigating the relationship of anxiety and depression with RP relies on the analysis of smaller subset populations of patients with RP, and no study has quantified the effect size of the potential association. This study aims to elucidate and quantify the association between RP, anxiety, and depression. Methods: A retrospective case-control study was conducted of 6 093 833 medical records within the University of North Carolina Hospital and outpatient clinic system from July 1, 2004, to August 30, 2019. Patients with a diagnosis of RP, anxiety, and depression were identified within the Carolina Data Warehouse for Health by International Classification of Diseases, Ninth and Tenth Revision codes. Results: From the base population of 6 093 833 patients' medical records, 690 patients were diagnosed with RP, 253 065 with anxiety, and 232 541 with depression. Patients with RP have an odds ratio, adjusted for sex and age, of 4.915 (95% CI, 4.035-5.987) for having comorbid anxiety, 5.609 (95% CI, 4.622-6.807) for comorbid depression, and 4.130 (95% CI, 3.187-5.353) for comorbid anxiety and depression. Conclusions: Patients with RP have a higher prevalence of anxiety and depression, with increased odds of approximately 5 to 6 times for also carrying a diagnosis of anxiety or depression and about 4 times for carrying diagnoses of anxiety and depression compared with the general population.
High Capacity Transmission in a Coupled-Core Three-Core Multi-Core Fiber

High-capacity, long-haul transmission over a coupled-core three-core multi-core fiber is investigated in a recirculating loop experiment. We report key system characteristics, such as the optimum launch power as well as the wavelength dependence and distance-evolution of mode-dependent loss and the impulse response time spread. We further performed two high data-rate, long-haul transmission demonstrations with more than 75 nm optical bandwidth in C- and L-bands over distances up to 4800 km. The reported data-rate of 172 Tb/s over 2040 km is the highest demonstrated in any multi-span transmission system employing optical fibers with standard cladding diameter of 125 micro-meter to date. Additionally, transmission of 81 Tb/s over 4800 km distance demonstrates the potential of using coupled-core multi-core fibers in combination with wideband optical signals over long-haul distances.
Treatment Components and Participant Characteristics Associated With Outcomes in Self-Monitoring Interventions

Self-monitoring is one of the most widely used and widely researched strategies for improving student behavior. However, specific research-based guidance about how to design effective self-monitoring interventions and to whom they should be delivered does not yet exist. To this end, we examined how various treatment components and participant characteristics moderated response to self-monitoring interventions. We included 66 single-case studies on academic engagement and 21 single-case studies on disruptive behavior. These studies included 290 participants with challenging behavior, 183 of whom had a disability. After extracting raw data from original studies, we analyzed data using multilevel modeling for each dependent variable (i.e., academic engagement, disruptive behavior). Across both dependent variables, student age and educational setting impacted treatment effects, as did the inclusion of goal-setting, feedback, and reinforcement. Based on our findings, we describe implications related to designing self-monitoring interventions. We also discuss limitations and future directions.