Miracle-dz/UniFAR-FTUs huggingface dataset:
Priming Sentence Production in Older Adults: Evidence for Preserved Implicit Learning

ABSTRACT Purpose Structural priming- speakers’ unconscious tendency to echo previously encountered message-structure mappings - is thought to reflect the processes of implicit language learning that occur throughout the lifespan. Recently, structural priming has also been used as a means to facilitate language re-learning in age-related language disorders such as aphasia. However, little evidence is available on whether structural priming remains effective in healthy aging, limiting clinical translation of the structural priming paradigm. This study examined the impact of aging on the strength and longevity of abstract structural priming and lexical boost effects. Method Twenty-four young and 24 older adults participated in a collaborative picture-matching task where the participant and experimenter took turns describing picture cards using transitive and dative sentences. In Experiment 1, a target was elicited immediately following a prime (0-lag), whereas two filler items were embedded between a prime and a target sentence in Experiment 2 (2-lag) to examine longer-term priming effects. In both experiments, the verb was repeated for half of the prime-target pairs to examine lexical boost on structural priming. Results At immediate priming, older adults showed both abstract structural priming and lexical boost in transitives and datives, similar to young adults. At longer-term priming, only abstract priming effects were significant in both groups of participants, with no evidence of age-related reduction in priming. Conclusions Both lexically-specific and independent mechanisms of structural priming remain resilient in older adults, supporting the view that structural priming reflects life-long language learning. Further, the findings provide empirical basis for applying structural priming to elderly clinical populations.
CBP and p300 Jointly Maintain Neural Progenitor Viability but Play Unique Roles in the Differentiation of Neural Lineages

The paralogous lysine acetyltransferases 3 (KAT3), CBP and P300, play critical roles during neurodevelopment, but their specific roles in neural precursors maintenance and differentiation remain obscure. In fact, it is still unclear whether these proteins are individually or jointly essential in processes such as proliferation of neural precursors, differentiation to specific neural cell types, or both. Here, we use subventricular zone-derived neurospheres as a potential ex vivo developmental model to analyze the proliferation and differentiation of neural stem cells (NSCs) lacking CBP, p300, or both proteins. The results showed that CBP and p300 are not individually essential for maintenance and proliferation of NSCs, although their combined ablation seriously compromised cell division. In turn, the absence of either of the two proteins compromised the differentiation of NSC into the neuronal and astrocytic lineages. Single-nucleus RNA sequencing analysis of neural cell cultures derived from CBP or p300 mutant neurospheres revealed divergent trajectories of neural differentiation upon CBP or p300 ablation, confirming unique functions and nonredundant roles in neural development. These findings contribute to a better understanding of the shared and individual roles of KAT3 proteins in neural differentiation and the etiology of neurodevelopmental disorders caused by their deficiency.
Volumetric, Compressibility and Viscometric Approach to Study the Interactional Behaviour of Sodium Cholate and Sodium Deoxycholate in Aqueous Glycyl Glycine

Viscosity, speed of sound (u), and density (ρ) have been measured in aqueous glycyl glycine solution over a temperature range from 293.15 to 313.15 K with a 5 K interlude to evaluate the volumetric and compressibility properties of bio-surfactants, namely sodium cholate (NaC; 1–20 mmol∙kg−1) and sodium deoxycholate (NaDC; 1–10 mmol∙kg−1). Density and viscosity findings provide information on both solute–solute and solute–solvent types of interactions. Many other metrics, such as apparent molar adiabatic compression (κS,φ), isentropic compressibility (κS), and apparent molar volume (Vφ), have been calculated from speed of sound and density measurements, utilising experimental data. The results show that the zwitterionic end group in the glycyl glycine strongly interacts with NaDC and NaC, promoting its micellization. Since the addition of glycyl glycine causes the bio-surfactant molecules to lose their hydrophobic hydration, the observed concentration-dependent changes in apparent molar volume and apparent molar adiabatic compression are likely attributable to changes in water–water interactions. Viscous relaxation time (τ) increases significantly with a rise in bio-surfactant concentration and decreases with increasing temperature, which may be because of structural relaxation processes resulting from molecular rearrangement. All of the estimated parameters have been analysed for their trends with regard to the different patterns of intermolecular interaction present in an aqueous glycyl glycine solution and bio-surfactant system.
Optimality and Duality for Nonsmooth Multiobjective Fractional Programming with Generalized Invexity

Abstract In this paper, we consider a class of nonsmooth multiobjective fractional programming problems in which functions are locally Lipschitz. We establish generalized Karush–Kuhn–Tucker necessary and sufficient optimality conditions and derive duality theorems for nonsmooth multiobjective fractional programming problems containing V -ρ-invex functions.
Polar mesosphere summer echo detection using a dynasonde

We describe a new polar mesosphere summer echo (PMSE) radar system implementation that uses a snow‐buried antenna operated with the dynasonde at Halley, Antarctica (76°S), the highest southern latitude at which any PMSE measurements have been made to date. Two 100 m2 coaxial‐collinear antenna arrays were built so that the antenna beams were colocated at 85 km altitude. Operations in PMSE mode began on 20 January 2004, close to the maximum operational frequency of the system at 28 MHz. PMSE signals were observed at the end of the Antarctic summer season in 2004 and subsequently during the austral summer of 2004/2005 at similar altitudes to PMSE observed in the Northern Hemisphere. We compare the sensitivity of the system to the well‐known mesosphere‐stratosphere‐troposphere radar at Poker Flat (65°N, 147°W, 50 MHz) and calculate a volume reflectivity at 28 MHz of η = 2.9 × 10−11 m−1, which is consistent with that determined from Northern Hemisphere radar systems operating at higher frequencies.
Theoretical analysis of observed second bulk compressional wave in a fluid-saturated porous solid at ultrasonic frequencies

We show that the second bulk compressional wave observed recently in an experiment by Plona is consistent with the ’’slow’’ compressional wave as predicted by Biot’s theory. We present dispersion and attenuation curves for all of the body waves for Plona’s samples computed as a function of frequency and Biot’s structure factor S. At high frequencies the velocity of the slow compressional wave is approximately equal to Vf/ S1/2, where Vf is the normal compressional‐wave velocity in the pore fluid. Thus, from the measured velocities of slow compressional waves one can obtain S. For Plona’s three samples, the predicted structure factors are 2.1, 2.2, and 3.3.
High resolution refractive index sensor with a crossed guided-mode resonant grating

A high resolution refractive-index sensor with a guided-mode resonant grating has been proposed. The gratin has a two-dimensionally periodic structured surface, which is covered with liquid to be measured. The resonant wavelength depends on the polarization states of light for oblique incidence. The change in refractive index of the liquid is determined from the difference of reflectance (or transmittance) between the P and S polarized light waves. The lattice structured silica substrate with a period of 380 nm was made. And a hafnium-dioxide thin film was deposited on the substrate. When the grating surface was covered with water, the measured reflectance had resonant peaks at a wavelength of 615 nm for S polarization and 617 nm for P polarization at an incident angle of 0.5°. For a wavelength of 616 nm, the difference of transmittance of P and S polarization was in linear relation to the change in refractive index. The refractive index was detected with a resolution of 4x10-4 in a measurement range of 0.064.
Observations of Kelvin‐Helmholtz waves along the dusk‐side boundary of Mercury's magnetosphere during MESSENGER's third flyby

During the third MESSENGER flyby of Mercury on 29 September 2009, 15 crossings of the dusk‐side magnetopause were observed in the magnetic field data over a 2‐min period, during which the spacecraft traveled a distance of 0.2 RM (where RM is Mercury's radius). The quasi‐periodic nature of the magnetic field variations during the crossings, the characteristic time separations of ∼16 s between pairs of crossings, and the variations of the magnetopause normal directions indicate that the signals are likely the signature of surface waves highly steepened at their leading edge that arose from the Kelvin‐Helmholtz instability. At Earth, the Kelvin‐Helmholtz instability is believed to lead to the turbulent transport of solar wind plasma into Earth's plasma sheet. This solar wind entry mechanism could also be important at Mercury.
Pengaruh Profitabilitas, Solvabilitas dan Likuiditas terhadap Harga Saham

Saham merupakan surat berharga sebagai bukti penyertaan atau kepemilikan individu maupun institusi dalam suatu perusahaan. Dengan adanya aktivitas transaksi jual dan beli saham di pasal modal oleh investor maka akan menimbul adanya harga saham. Harga saham merupakan cerminan dari keberhasilan pengelolaan perusahaan dalam mengelola usahanya saat ini ataupun dimasa yang akan datang, sehingga hal ini sangat penting bagi investor dalam menilai suatu perusahaan. Tujuan dari penelitian ini untuk menguji dan menganalis pengaruh profitabilitas, solvabilitas, dan likuiditas terhadap harga saham. Data yang digunakan pada penelitian ini adalah data sekunder. Pengambilan sampel menggunakan teknik purposive sampling dengan populasi perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia (BEI) periode 2016-2020. Sampel penelitian diperoleh sebanyak 15 perusahaan (75 sampel). Dalam penelitian ini alat analisis yang digunakan adalah regresi linear berganda. Hasil penelitian ini menunjukkan bahwa variabel profitabilitas berpengaruh positif terhadap harga saham. Sementara itu variabel solvabilitas dan likuiditas tidak memiliki pengaruh terhadap harga saham.
From the chromatin interaction network to the organization of the human genome into replication N/U-domains

The three-dimensional (3D) architecture of the mammalian nucleus is now being unraveled thanks to the recent development of chromatin conformation capture (3C) technologies. Here we report the results of a combined multiscale analysis of genome-wide mean replication timing and chromatin conformation data that reveal some intimate relationships between chromatin folding and human DNA replication. We previously described megabase replication N/U-domains as mammalian multiorigin replication units, and showed that their borders are ‘master’ replication initiation zones that likely initiate cascades of origin firing responsible for the stereotypic replication of these domains. Here, we demonstrate that replication N/U-domains correspond to the structural domains of self-interacting chromatin, and that their borders act as insulating regions both in high-throughput 3C (Hi-C) data and high-resolution 3C (4C) experiments. Further analyses of Hi-C data using a graph-theoretical approach reveal that N/U-domain borders are long-distance, interconnected hubs of the chromatin interaction network. Overall, these results and the observation that a well-defined ordering of chromatin states exists from N/U-domain borders to centers suggest that ‘master’ replication initiation zones are at the heart of a high-order, epigenetically controlled 3D organization of the human genome.
Illusion of flight? Absence, evidence and the age of winged insects

The earliest fossils of winged insects (Pterygota) are mid-Carboniferous (latest Mississippian, 328–324 Mya), but estimates of their age based on fossil-calibrated molecular phylogenetic studies place their origin at 440–370 Mya during the Silurian or Devonian. This discrepancy would require that winged insects evaded fossilization for at least the first ~50 Myr of their history. Here, we examine the plausibility of such a gap in the fossil record, and possible explanations for it, based on comparisons with the fossil records of other arthropod groups, the distribution of first occurrence dates of pterygote families, phylogenetically informed simulations of the fossilization of Palaeozoic insects, and re-analysis of data presented by Misof and colleagues using updated fossil calibrations under a variety of prior probability settings. We do not find support for the mechanisms previously suggested to account for such an extended gap in the pterygote fossil record, including sampling bias, preservation bias, and body size. We suggest that inference of an early origin of Pterygota long prior to their first appearance in the fossil record is probably an analytical artefact of taxon sampling and choice of fossil calibration points, possibly compounded by heterogeneity in rates of sequence evolution or speciation, including radiations or ‘bursts’ during their early history.
Attenuation Effects in Spiral Galaxies: Multiwavelength Photometry and Disk Radiative Transfer Models

We present a quantitative investigation of the optical depth through spiral disks using BVRIJHK colors of 15 highly inclined Sab–Sc spirals and new models for radiative transfer in stellar disks. The models include exponential stellar and dust disks, exponential stellar bulge components, multiple scattering, and both homogeneous and clumpy dust distributions. Preliminary comparisons of the observed optical and near-infrared (NIR) color gradients across galaxy dust lanes with predictions from radiative transfer models with slab and spherical shapes underscore the need for these realistic exponential disk geometries. When compared with the extent of reddening predicted by the disk models, the maximum optical and NIR color excesses in galaxy dust lanes imply central face-on optical depths of 0.5–2.0 in the V band. For these highly inclined systems, we find this inferred optical depth to be largely insensitive to the difference between clumpy and homogeneous dust distributions. Comparisons of galaxy color gradients to models with high central optical depths contradict the often-stated claim that spiral disks are opaque out to D25. Our derived optical depths show that the predicted radial color changes caused by attenuation in face-on galaxies are much smaller than the observed color gradients in such systems, which suggests that the observed changes are the result of variations in stellar content. The face-on optical depths also imply that, when viewed edge-on, galaxy dust lanes have optical depths greater than 1.0 even in the K band and, thus, the NIR mass-to-light ratio changes across dust features.
Different In Vitro Drug Susceptibility Profile of Plasmodium falciparum Isolates from Two Adjacent Areas of Northeast Myanmar and Molecular Markers for Drug Resistance

The Greater Mekong Subregion (GMS) is the epicenter of antimalarial drug resistance. We determined in vitro susceptibilities to 11 drugs of culture-adapted Plasmodium falciparum isolates from adjacent areas (Laiza and Muse) along the China–Myanmar border. Parasites from this region were highly resistant to chloroquine and pyrimethamine but relatively sensitive to other antimalarial drugs. Consistently, the Dd2-like pfcrt mutations were fixed or almost fixed in both parasite populations, and new mutations mediating piperaquine resistance were not identified. Similarly, several mutations related to pfdhfr and pfdhps were also highly prevalent. Despite their geographical proximity, malaria parasites from Laiza showed significantly higher in vitro resistance to artemisinin derivatives, naphthoquine, pyronaridine, lumefantrine, and pyrimethamine than parasites from Muse. Likewise, the pfdhfr N51I, pfdhps A581G, pfmrp1 H785N, and pfk13 F446I mutations were significantly more frequent in Laiza than in Muse (p < 0.05). For the pfmdr1 mutations, Y184F was found only in Laiza (70%), whereas F1226Y was identified only in Muse (31.8%). Parasite isolates from Laiza showed a median RSA value of 5.0%, significantly higher than the 2.4% in Muse. Altogether, P. falciparum parasite populations from neighboring regions in the GMS may diverge substantially in their resistance to several antimalarial drugs. This information about different parasite populations will guide antimalarial treatment policies to effectively manage drug resistance during malaria elimination.
Grating-coupled silicon microring resonators

We propose to integrate grating-assisted asymmetric couplers with microring resonators for selective resonance excitation and control of coupling efficiency. A grating-coupled microring add-drop filter is experimentally demonstrated using a silicon-on-insulator technology compatible with complementary metal-oxide-semiconductor processing. A dominant longitudinal mode with a side-mode suppression ratio of 8 dB has been obtained across a broad spectral range of over 130 nm. The selected mode shows an out-of-band-rejection ratio of 19 dB and a quality factor (Q) of 25 000. The concept of integrating grating-assisted couplers for mode selectivity can be applied to other microring-based devices for high-Q, single-mode operations.
Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo

Gammaherpesviruses, such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, are important human pathogens involved in lymphoproliferative disorders and tumorigenesis. Herpesvirus infections are characterized by a biphasic cycle comprised of an acute phase with lytic replication and a latent state. Murine gammaherpesvirus 68 (MHV-68) is a well-established model for the study of lytic and latent life cycles in the mouse. We investigated the interplay between the type I interferon (IFN)-mediated innate immune response and MHV-68 latency using sensitive bioluminescent reporter mice. Adoptive transfer of latently infected splenocytes into type I IFN receptor-deficient mice led to a loss of latency control. This was revealed by robust viral propagation and dissemination of MHV-68, which coincided with type I IFN reporter induction. Despite MHV-68 latency control by IFN, the continuous low-level cell-to-cell transmission of MHV-68 was detected in the presence of IFN signaling, indicating that IFN cannot fully prevent viral dissemination during latency. Moreover, impaired type I IFN signaling in latently infected splenocytes increased the risk of virus reactivation, demonstrating that IFN directly controls MHV-68 latency in infected cells. Overall, our data show that locally constrained type I IFN responses control the cellular reservoir of latency, as well as the distribution of latent infection to potential new target cells.
Line Spectral Estimation Inspired by Quasi-Neural Network

Different from a conventional artificial neural network (ANN) typically being used as a data-driven classifier, the “quasi-neural network” (Quasi-NN), with its inputs, outputs, and activation functions being artfully defined to have explicit physical meaning, is recently proposed in the literature as a modeling tool. In this paper, we show that the classic problem of line spectral estimation can be modeled by a Quasi-NN with its weights being the frequencies and the coefficients of the sinusoids to estimate. Owing to the layered structure the same as an ANN, the weights of the Quasi-NN can be optimized using the celebrated back-propagation (BP) algorithm initialized by the fast Fourier transform (FFT) based spectral estimation. The optimized weights are the maximum likelihood (ML) estimation of the line spectrum parameters. We also design a method of merging and pruning the hidden-layer nodes of the Quasi-NN for model-order selection, i.e., to estimate the number of sinusoids. Numerical simulations verify the effectiveness of the proposed method.
Racial Discrimination and Economic Factors in Redlining of Ohio Neighborhoods

Abstract We examined the influence of racial and ethnic identity of residents and housing market economic conditions on redlining. Data were extracted from archival area description forms from the Home Owners’ Loan Corporation for 568 Ohio neighborhoods from 1934–1940. Logistic regression analysis was used to analyze the relationships between neighborhood characteristics and redlining. Bivariate results indicated a strong association between the presence of African American residents and neighborhood redlining (OR = 40.9, 95% CI 22.9-72.8). Multivariable analysis demonstrated that some neighborhood characteristics were contributors to the decision to redline, including homes in poor condition (OR = 4.3, 95% CI 1.2-15.1), home vacancy (OR = 1.4, 95% CI 1.1-1.6), and housing prices (per thousand dollars) (OR = 0.7, 95% CI 0.4-1.2). Adjusting for these and other factors, the presence of African American residents remained a powerful predictor of redlining (OR = 13.8, 95% CI 4.4-42.8). Racial discrimination was the overriding factor in decisions to redline neighborhoods.
Fluctuations of the orbital angular momentum of a laser beam, carrying an optical vortex, in the turbulent atmosphere

The evolution of the orbital angular momentum (OAM) of a Laguerre—Gaussian beam interacting with turbulent inhomogeneities of the atmosphere is studied theoretically. The integral representations are obtained for the OAM in terms of the distributions of the random intensity and random field of the permittivity of the medium, and also for OAM statistical characteristics in terms of corresponding correlation functions. It is found that the average OAM value is preserved during the propagation of the laser beam in a random medium. The dependence of the dispersion of OAM fluctuations on the atmospheric turbulence and beam parameters is calculated. It is shown that the dependence of the OAM dispersion on the initial angular momentum of the laser beam disappears in the case of very strong turbulence.
Three-dimensional atom probe investigation of boron distribution in CoFeB∕MgO∕CoFeB magnetic tunnel junctions

Significant lateral compositional variations have been revealed in a three-dimensional atom probe (3DAP) study of the MgO barriers of magnetic tunnel junctions. High resolution electron microscopy of the CoFeB∕MgO∕CoFeB∕Ru∕CoFe∕PtMn multilayer indicates that the MgO barrier is smooth, uniform, and with good crystallinity. Nevertheless, the 3DAP data show lateral variations in the MgO composition over length scales on the order of tens of nanometers. Boron is not uniformly distributed within the CoFeB layers, but has tended to segregate to the interfaces. Annealing has no significant effect on the distribution of B, indicating that the segregation occurring during growth is relatively stable.