Miracle-dz/UniFAR-FTUs huggingface dataset:
In-hospital clinical outcomes in kidney transplant recipients with COVID-19 infection

Introduction: The coronavirus 19 disease (COVID-19) increased mortality in organ solid transplant patients due to chronic immunosuppression and significant comorbidity burden. We aim to evaluate patient and graft survival in kidney transplant (KT) recipients who were hospitalized or treated in Intensive Care Units (ICU) after contracting COVID-19. Methods: A retrospective analysis was conducted on adult KT recipients diagnosed with COVID-19 between June 1 and July 31, 2021. The study reported demographics, symptoms, laboratory parameters, and clinical outcomes 30 days after a positive test. Risk factors for mortality were identified through comparisons between hospitalization-in-wards and ICU groups. The Kaplan-Meier method was used to calculate graft and patient survival. Results: 55 KT patients were analysed, recipient age and history of diabetes showed significant differences between groups (p = 0.0124 and p = 0.0506, respectively). Multivariate analysis revealed that diabetes (p = 0.002) and dialysis requirement (p = 0.0006) were significantly associated with mortality risk. The overall mortality rate was 25.5%, with graft loss at 12.7%. Patient survival after 30 days was 74.5%, with significantly higher survival in the hospitalization-in-wards group (p = 0.0001) compared to the ICU group. Conclusions: KT patients diagnosed with COVID-19 are at higher mortality risk than the general population. Our study found that patients in the ICU group experienced worse clinical outcomes and higher mortality rates compared to those in the hospitalization-in-wards group. These findings underscore the importance of closely monitoring COVID-19-implicated KT patients and tailoring treatment plans to minimize risk and improve outcomes.
A graded stream response relation for bed load–dominated streams

[1] The relation between equilibrium stream channel morphology and three independent governing variables, discharge, sediment supply, and valley slope, is investigated using a stream table. The experiments are based on a generic physical model of a laterally active gravel bed stream and directed by a recently published rational regime model. While a variety of channel adjustments are possible, the primary adjustment observed was in the channel slope. Other adjustments, such as surface armor composition and cross-sectional shape, were minor in comparison. The equilibrium slope is well predicted by a linear function of sediment concentration which is bounded by two thresholds: one associated with the minimum stream power necessary to deform the bed and the other associated with the maximum sediment feed that can be transported by the available flow. The results suggest that the system tends to move toward the minimum slope capable of transporting the sediment supply, in the process increasing the flow resistance for the system. Whether or not a minimum slope or a maximum system-scale flow resistance is reached cannot be determined given the available data, but there appears to be a unique slope (or, at least, a limited range of slopes) for which a stable alluvial channel morphology can be established for a given sediment concentration. The implications of this behavior are evaluated for the theoretical basis of the extremal hypothesis used to close the formulation of a rational regime model.
Unraveling the Thread of Aphasia Rehabilitation: A Translational Cognitive Perspective

Translational neuroscience is a multidisciplinary field that aims to bridge the gap between basic science and clinical practice. Regarding aphasia rehabilitation, there are still several unresolved issues related to the neural mechanisms that optimize language treatment. Although there are studies providing indications toward a translational approach to the remediation of acquired language disorders, the incorporation of fundamental neuroplasticity principles into this field is still in progress. From that aspect, in this narrative review, we discuss some key neuroplasticity principles, which have been elucidated through animal studies and which could eventually be applied in the context of aphasia treatment. This translational approach could be further strengthened by the implementation of intervention strategies that incorporate the idea that language is supported by domain-general mechanisms, which highlights the impact of non-linguistic factors in post-stroke language recovery. Here, we highlight that translational research in aphasia has the potential to advance our knowledge of brain–language relationships. We further argue that advances in this field could lead to improvement in the remediation of acquired language disturbances by remodeling the rationale of aphasia–therapy approaches. Arguably, the complex anatomy and phenomenology of aphasia dictate the need for a multidisciplinary approach with one of its main pillars being translational research.
PBL-Based Electronic Teaching Materials Using Flip PDF Corporate in Elementary Schools

Sejalan dengan perkembangan zaman, maka di perlukan pembelajaran menggunakan bahan ajar elektronik. Guru dituntut untuk dapat memenuhi kriteria pembelajaran yang sesuai dengan perkembangan teknologi. Penelitian ini bertujuan untuk mengembangkan bahan ajar elektronik berbasis Problem Based Learning (PBL) menggunakan flip pdf corporate yang valid. Metode pengembangan menggunakan model ADDIE dengan tahap analisis, desain, pengembangan, implementasi, dan evaluasi. Penelitian ini meliputi metode pengumpulan data lembar validasi dari validator media, validator bahasa, dan validator materi. Pengumpulan data praktikalitas angket respon peserta didik dan guru. Hasil uji validasi media 93.75% masuk kategori sangat valid, hasil validasi materi 93.75% masuk kategori sangat valid, hasil validasi bahasa 95% masuk kategori sangat valid. hasil uji praktikalitas guru 97,14% dengan kategori sangat praktis dan peserta didik 93,7% dengan kategori sangat praktis. Dengan bukti hasil validasi produk dan hasil praktiklitas tersebut disimpulkan bahwa bahan ajar elektronik berbasis PBL menggunakan flip pdf corporate di sekolah dasar adalah valid dan praktis. Penelitian ini berimplikasi pada variasi bahan ajar yang valid untuk menunjang proses pelaksanaan pembelajaran.
Does Fintech-Driven Inclusive Finance Induce Bank Profitability? Empirical Evidence from Developing Countries

This study explores the effect of fintech-driven inclusive finance on the profitability of banks using an unbalanced panel dataset from 660 banks across 40 developing countries between 2011 and 2021. We start with a fixed-effect estimate and subsequently validate our main findings using two-stage least squares (2SLS-IV), two-step system generalized method of moments (GMM), and generalized least squares (GLS) methodologies. Our analysis centers on three key profitability metrics: ROA, ROE, and NIM. Our findings suggest that fintech-backed inclusive finance boosts ROA by 9.10%, ROE by 18.87%, and NIM by 7.98%, highlighting the growing importance of mobile, internet, and agent banking in these nations. We also note that large banks benefit more from inclusive finance than small ones. Additionally, conventional banks see a more marked improvement in profitability than Islamic and savings banks. The relationship between inclusive finance and bank profitability is stronger in countries with higher GDP growth and those actively advancing financial inclusion through fintech, compared to countries with slower GDP growth and less emphasis on financial inclusion. When examining the interaction effects, the COVID-19 pandemic has further emphasized the positive connection between fintech and bank profitability. This suggests that fintech-driven inclusive finance can play a role in enhancing bank profitability, even in challenging times like the COVID-19 period. The transition towards fintech, however, mandates substantial investments, enhanced financial literacy, and heightened customer security, presenting persistent challenges for governments, policymakers, regulators, and financial institutions.
Screening and preliminary analysis of differentially expressed genes in quail embryos for feather colour based on RNA-Sequencing

The purpose of this study was to use RNA-Sequencing (RNA-Seq) to screen differentially expressed genes (DEGs) and analyse transcriptomic data from embryonic skin tissues of maroon-feather and white-feather quails. The transcriptome of embryonic skin tissues from quails was sequenced using the Illumina HiSeqTM 2000 sequencing platform. A total of 2 512 DEGs were found. Of these, 550 DEGs were up-regulated and 1 562 DEGs were down-regulated in the skin tissues of white-feather quail embryos. Five hundred and ninety-seven DEGs were enriched and annotated into 50 entries in Gene Ontology (GO) database. The total number of DEGs annotated in each entry in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database was 341, enriched in 230 pathways, of which the tight junction pathway and neuroactive ligand-receptor interaction were the most significantly enriched. Candidate genes were analysed using real-time quantitative reverse transcription polymerase chain reaction (to verify the accuracy and reliability of the RNA-Seq results. The relative expression of agouti signalling protein (ASIP) and DOPA decarboxylase (DDC) in white-feather quails were increased. Relative expression of homeobox D1 (HOXD1), cathepsin D (CTSD), keratin 2 (KRT2), methyl-CpG binding domain protein 2 (MBD2), and melatonin receptor 1 (MT1) were decreased. The results of this study provide useful data on the analysis of the feather colour regulatory mechanism in white- and maroon-feather quails.
The Emotional Experience of Mexican Women with SARS-CoV-2 during Pregnancy―A Qualitative Study

Pregnant women have been considered a high-risk group for SARS-CoV-2 infection; the impact of the disease on the health of a mother and her child is still being studied. The emotional impact of the pandemic on pregnant women has been extensively studied. Emotional distress is proposed as a perspective to explain the emotional manifestations in women during this stage as something common rather than pathological. The objective of this study was to explore the emotional experience of women who tested positive for SARS-CoV-2 towards the end of their pregnancy, during the first and second waves of COVID-19 in Mexico. A qualitative study was carried out: 18 pregnant women with COVID-19 were interviewed. A thematic analysis of the data was performed, resulting in 3 main themes and 14 subthemes. The COVID-19-infected mothers-to-be experienced mild to moderate emotional distress. It was more intense for those with comorbidities. This distress was aggravated during obstetrical complications and comorbidities, as well as during COVID-19 and postpartum. The emotional distress was appeased by both the perception of medical care and social support. The emotional distress of pregnant women with COVID-19 requires emotional support to reduce its impact.
Evaluation of the Relation between Noise and Vibration Exposure with Job Burnout in City Bus Drivers

Introduction: Today, burnout has emerged as a significant concern affecting the well-being of employees within various groups and organizations. Numerous factors, including vibrations and noise, have been identified as impacting job burnout. City bus drivers are individuals who are frequently exposed to a wide range of stressors and pressures. Consequently, this study aims to evaluate the influence of noise and vibration exposure on job burnout specifically city bus drivers in Neyshabur. Material and method: In the conducted study, a total of 62 bus drivers from Neishabur city participated. To accurately measure sound levels, a TES dosimeter was employed, while vibration levels were assessed using an SV 106 vibration meter. As for job burnout, the researchers utilized the well-established Maslach questionnaire. Result: The present study reveals notable findings regarding the frequency levels of various dimensions among bus drivers. Particularly, the dimension of emotional exhaustion and depersonalization exhibited the highest percentage at a medium level. Moreover, all bus drivers scored high on the dimensions of lack of success and lack of efficiency. the dimension of emotional exhaustion and depersonalization was found to have the highest frequency percentage, particularly at a medium level. Results from the correlation test indicated a significant relationship between emotional fatigue and various factors, such as the number of working hours per week, amount of overtime per week, number of services, and exposure to vibrations. Additionally, a significant relationship was observed between the depersonalization dimension and the number of services, noise exposure, as well as lack of success and the number of services. Furthermore, a significant relationship between the lack of success dimension and the number of services and exposure to vibrations was identified. Conclusion: Factors such as the quantity of working hours, overtime, the number of services within the driving profession, as well as exposure to high levels of noise and vibration, have been identified as influential factors on job burnout. It is plausible to mitigate work burnout in driving occupations by implementing strategies such as reducing working hours, utilizing contemporary and low-vibration vehicles, and rotating work shifts between drivers in bustling and clamorous locales with more serene urban environments.
Baroreceptor Reflex Sensitivity in Patients with Atrial Fibrillation

Purpose: Persistent atrial fibrillation decreases baroreflex sensitivity (BRS), which is considered an indicator of cardiac autonomy. Furthermore, atrial fibrillation ablation has also been found to reduce the BRS. The baseline BRS of patients with paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation (PeAF) was compared and the BRS-modifying effect of ablation was investigated. Methods: The BRS was measured before and after the procedure and the presence or absence of atrial fibrillation recurrence was assessed. Results: Pre-operative BRS was significantly lower in patients with PeAF compared with those with PAF. The BRS was significantly reduced postoperatively in all patients, with a particularly large reduction in PAF patients. The BRS decreased to a lesser extent with ablation in patients with recurrent PAF. Conclusions: Baseline BRS was lower in patients with PeAF. Atrial fibrillation ablation reduced BRS in both PAF and PeAF patients but had a stronger reduction effect in PAF patients.
Anti-Glycation, Anti-β-Amyloid Aggregation, and Antioxidant Effect of Cassia Seed-Derived Secondary Metabolites

Aggregation and non-enzymatic glycation of amyloidogenic peptides, amyloid-beta (Aβ), and insulin are key features of neuropathology. In this study, we evaluate the anti-glycation effect of Cassia seed-derived secondary metabolites on human insulin and bovine serum albumin, as well as their anti-Aβ aggregation and antioxidant effects using in vitro spectrofluorometric method, thioflavin T fluorescence, and peroxynitrite (ONOO‒) scavenging assay. Furthermore, molecular docking simulation was performed to investigate the binding characteristics of test compounds and Aβ42 peptide. Among 38 compounds, anthraquinones 9–12 and 14–18; naphthopyrones 24, 25, 27, and 33–36; and 38 from the naphthalenes and naphthalenic lactone groups showed moderate-to-good inhibition of AGE formation with IC50 values ranging from 7.52 ± 1.19 to 155.86 ± 0.79 µM. Likewise, compounds 5, 24, 15, 16, 27, and 20 showed good inhibition of D-ribose-mediated glycation of human insulin, with an IC50 value range of 46.37 ± 4.06 to 97.69 ± 7.88 µM. In the thioflavin-T assay, compounds 8 and 12 showed promising inhibition of Aβ aggregation, comparable to that of the reference compound morin. Molecular docking simulations confirmed that these active compounds have strong potential to interact with Aβ42 peptides and interrupt their self-assembly and conformational transformation, thereby inhibiting Aβ42 aggregation. In addition, compounds 5, 8, 10, 14, and 35 scavenged ONOO− at low concentrations. Overall, Cassia compounds’ anti-glycation, anti-Aβ aggregation, and antioxidant effects warrant further in vivo studies to evaluate their potential neuroprotective effects against comorbid AD and diabetes.
Mesenchymal Stem Cells-Derived Extracellular Vesicles as Nanotherapeutics: An Application for Skin Wound Healing

The skin covers the entire outer part of the body as the largest organ. Because this organ is directly exposed to microbial, thermal, mechanical, and chemical damage, several factors may injure it, including acute trauma, chronic wounds, or even surgical procedures. Mesenchymal stem cells- (MSCs-) derived extracellular vesicles (EVs) can inhibit the inflammatory response in the early stage of skin wound healing, promote angiogenesis and the proliferation and migration of epithelial cells, and regulate collagen synthesis and inhibit scar proliferation in the later stage. While MSCs-EVs have broad prospects for clinical applications, it will still be a long way to seamless healing. In this brief review, we focus on the role of MSCs-EV in skin wound repair, therapeutic effects, and potential mechanisms of MSCs-EV in reducing scar formation. It is concluded that MSCs-EV can reduce scar formation in skin wound repair by interfering with multiple inflammatory factors, regulating fibroblast proliferation, and expressing type I and type III collagens at different phases.
author-version of: Measurement and analysis of vibration and shock levels for truck transport in Belgium with respect to packaged beer during transit

(150 words) Temperature, vibrations and shocks during transport and storage are believed responsible for beer flavour instability. The aim of current study is twofold: (1) to quantify the vibrations and shocks on packaged bottled beer when travelling on the Belgian road network, (2) quantify the impact of the vibrations and shocks in a preliminary experiment. The spectral density plots illustrate the importance of low-frequency vibrations and the similarities/discrepancies with international standards (ASTM-D4728 and ISO-13355). With increasing stack height, the amplitude of vibrations (5-25Hz) intensifies in both corrugated boxes and plastic crates. Vibrations >25Hz are amplified up to 9 times the original signal depending on the stack height of plastic crates. Corrugated boxes attenuate vibrations >25Hz. Corrugated boxes absorb shocks and are preferred over plastic crates with respect to shocks and vibrations. In an exploratory experiment, vibrations and shocks induce the uptake of oxygen and the change of aldehydes (dependency initial oxygen content).
In ﬂ ation Bets or De ﬂ ation Hedges? The Changing Risks of Nominal Bonds

The covariance between US Treasury bond returns and stock returns has moved considerably over time. While it was slightly positive on average in the period 1953— 2005, it was particularly high in the early 1980’s and negative in the early 2000’s. This paper speci ﬁ es and estimates a model in which the nominal term structure of interest rates is driven by four state variables: the real interest rate, risk aversion, expected in ﬂ ation, and the covariance between nominal variables and the real economy. Log nominal bond yields and term premia are quadratic in these state variables, with term premia determined mainly by the product of risk aversion and the nominal-real covariance. The concavity of the yield curve–the level of intermediate-term bond yields, relative to the average of short-and long-term bond yields–is a good proxy for the level of term premia.
require-The effect of concentrate feeding amount and feeding strategy on milk production, dry matter intake, and energy partitioning of autumn-calving Holstein-Friesian cows

The objective of this study was to compare the milk production, dry matter intake, and energy partitioning of autumn-calving Holstein-Friesian cows offered a high or low amount of concentrate using 1 of 2 feeding strategies. One hundred and eight autumn-calving Holstein-Friesian cows were blocked based on milk production data from wk 3 and 4 of lactation, and were divided into low-, medium, and high-milk yield subgroups. Cows were randomly assigned to 1 of 4 treatments (n = 27) in a 2 × 2 factorial design. Treatment factors were concentrate feeding amount, high concentrate = 7.0 (Hi) or low concentrate = 4.0 kg of DM/cow per day (Lo), and concentrate feeding strategy, flat rate (FR) or group-fed to yield (GFY). In the GFY treatments, cows were allocated concentrate based on their milk yield in the third and fourth weeks of lactation. The lowest-yielding cows (n = 9) received 5.3 and 2.3 kg of DM of concentrate on the Hi and Lo treatments respectively, the highest-yielding cows (n = 9) received 8.7 and 5.7 kg of DM of concentrate on the Hi and Lo treatments respectively, and the average yield cows received the same amount of concentrate as the corresponding FR group (i.e., 7.0 and 4.0 kg of DM of concentrate on the Hi and Lo treatments, respectively). The proportion of forage in the diet was 63% of total dry matter intake (TDMI) for the Hi treatment and 75% of TDMI for the Lo treatment. No significant interaction was noted between concentrate feeding amount and concentrate feeding strategy for dry matter intake or milk yield. Cows on the Hi treatment had a higher TDMI (18.7 ± 0.36 kg/cow per day) compared with cows on the Lo treatment (15.8 ± 0.36 kg/cow per day). The milk yield of cows offered the Hi treatment was 1.3 kg/cow per day higher than the milk yield of cows on the Lo treatment (23.8 ± 0.31 kg/cow per day). Milk solids yield was 0.10 kg/cow per day higher on the Hi treatment than on the Lo treatment (1.83 ± 0.03 kg of DM/cow per day). Cows on the Hi treatment had an estimated net energy demand of 18.0 ± 0.38 UFL (unité fourragère lait)/cow per day and a net energy intake of 17.6 ± 0.33 UFL/ cow per day during the experimental period. Cows on the Lo treatment had an energy demand of 16.8 ± 0.38 UFL/cow per day and an energy intake of 14.9 ± 0.33 UFL/cow per day. No significant difference in TDMI, milk yield, milk solids yield, or energy balance was observed between the FR and GFY treatments. By increasing the total amount of concentrate offered, cows had higher TDMI and energy intake, which resulted in increased milk production and reduced negative energy balance and body condition score loss.