Miracle-dz/UniFAR-FTUs huggingface dataset:
Global-scale combustion sources of organic aerosols: sensitivity to formation and removal mechanisms

Abstract. Organic compounds from combustion sources such as biomass burning and fossil fuel use are major contributors to the global atmospheric load of aerosols. We analyzed the sensitivity of model-predicted global-scale organic aerosols (OA) to parameters that control primary emissions, photochemical aging, and the scavenging efficiency of organic vapors. We used a computationally efficient module for the description of OA composition and evolution in the atmosphere (ORACLE) of the global chemistry–climate model EMAC (ECHAM/MESSy Atmospheric Chemistry). A global dataset of aerosol mass spectrometer (AMS) measurements was used to evaluate simulated primary (POA) and secondary (SOA) OA concentrations. Model results are sensitive to the emission rates of intermediate-volatility organic compounds (IVOCs) and POA. Assuming enhanced reactivity of semi-volatile organic compounds (SVOCs) and IVOCs with OH substantially improved the model performance for SOA. The use of a hybrid approach for the parameterization of the aging of IVOCs had a small effect on predicted SOA levels. The model performance improved by assuming that freshly emitted organic compounds are relatively hydrophobic and become increasingly hygroscopic due to oxidation.
Patients’ Perceived Satisfaction Through Telephone-Assisted Tele-Consultation During the SARS-CoV-2 Pandemic Period: Observational Single-Centre Study at a Tertiary-Referral Colorectal Surgery Department

Introduction: The pandemic produced by SARS-CoV-2 has obliged us to set up the tele-assistance to offer a continuity of care. This implies an innovation, being the degree of satisfaction of patients unknown. Methods: A telephonic survey was conducted with the validated in the Spanish tool Telehealth Usability Questionnaire (Telehealth Usability Questionnaire; rating from 1-7) of all candidate patients assisted consecutively in the Coloproctology Unit. We included demographic variables, education level, job status, diagnosis and consultation type. A descriptive study was done. The relationship between the willingness of consultation model in the future (telemedicine vs traditional) and the categorical variables was analysed through the chi-squared test. Results: A total of 115 patients were included. The average age was 59.9 years, being 60% women. The average score in each of the survey items was higher than 6 in all the questions but 1. 26.1% of the surveyed patients confessed being advocated to tele-assistance in the future. The only factors related to greater willingness to tele-assistance were male gender (37% vs 18.8%; P = .03) and a higher academic preparation level in favour of higher technical studies (35.9%) and university studies (32.4%) opposite to the rest (P = .043). The rest of variables studied, job status, labour regimen, diagnostic group and consultation type did not show any relationship. Conclusions: A vast majority of patients answered favourably to almost all the items of the survey. However, only 26.1% of them would choose a model of tele-assistance without restrictions.
Occurrence and Predictors of Challenging Behavior in Youth with Intellectual Disability with or without Autism

ABSTRACT Introduction : Challenging behaviors are common in individuals with developmental disabilities and pose significant challenges to their well-being and that of their families and communities. Method : We explored the occurrence and predictors of self-injurious behavior and aggressive/destructive behavior in 372 Canadian youths (aged 4–20 years) with a moderate to severe intellectual disability (ID), with or without autism. Data were collected through the Great Outcomes for Kids Impacted by Severe Developmental Disabilities (GO4KIDDS) basic survey. Results : Parent-report survey data indicated that 56% of the sample had displayed aggressive/destructive behavior and 39% self-injurious behavior over the past 2 months. Both behaviors were significantly more common in youths with ID plus autism compared to ID alone. There was an interaction between diagnosis and adaptive behavior in relation to aggressive/destructive behavior. For those with ID alone, lower adaptive functioning was predictive of aggressive/destructive behavior, whereas for those with ID plus autism, higher adaptive functioning was predictive. Conclusion : Overall, a large proportion of children in the sample were reported to engage in at least one challenging behavior. These findings highlight the importance of differential diagnosis, and an assessment of adaptive function to ascertain the prognosis of challenging behavior. Study limitations and avenues for future research are discussed.
Ticks (Parasitiformes: Ixodida) on new world wild primates in Brazil

ABSTRACT Brazil concentrates the largest number of primate species in the world. In the present study, an extensive literature review of ticks on New World wild monkeys has been carried out, demonstrating that between the years 1912 to 2018, 182 larvae, 137 nymphs and 31 adult ticks (10 males and 21 females) were collected on 78 primates (from 12 different species) in 28 distinct localities in the Brazilian territory. Additionally, examination of allotments of 11 tick collections of Brazil revealed that from 1919 to 2019, 93 larvae, 91 nymphs and 175 adult ticks (62 males and 113 females) were collected from 100 monkeys (among 20 different species) from 43 localities in distinct Brazilian biomes. Overall, 19 tick species were identified on wild primates in the country: Amblyomma aureolatum (Pallas, 1772), Amblyomma cajennense (Fabricius, 1787) sensu stricto, Amblyomma coelebs Neumann, 1899, Amblyomma dubitatum Neumann, 1899, Amblyomma geayi Neumann, 1899, Amblyomma incisum Neumann, 1906, Amblyomma longirostre (Koch, 1844), Amblyomma naponense (Packard, 1869), Amblyomma nodosum Neumann, 1899, Amblyomma ovale Koch, 1844, Amblyomma parkeri Fonseca & Aragão, 1952, Amblyomma romarioi Martins, Luz & Labruna, 2019, Amblyomma rotundatum Koch, 1844, Amblyomma sculptum Berlese, 1888, Haemaphysalis juxtakochi Cooley, 1946, Ixodes fuscipes Koch, 1844, Rhipicephalus microplus (Canestrini, 1888), Rhipicephalus sanguineus (Latreille, 1806) sensu lato,and Ornithodoros rostratus Aragão, 1911. The presence of A. incisum, A. naponense, A. nodosum, A. rotundatum and I. fuscipes on monkeys is recorded for the first time. Thisresearch is therefore a significant contribution to the knowledge of tick speciesassociated with non-human primates in the Neotropical region.
An “ideological fantasy”: how market discourses confuse, obscure and deflect consumers’ attention away from the science of energy conservation

ABSTRACT Our research focuses on sustainable energy use and our aim is to establish if communication at critical social interfaces is providing information that motivates pro-environmental behaviour change. Here we focus on one key site of energy-related information exchange – the interface between energy retailer and domestic energy consumer. Our interpretive analysis involved a comparative discourse analysis of consumers’ accounts of their communication with their energy retailers and exposed a dialogic failure, perpetrated by an ‘ideological fantasy’ of consumer empowerment that appears to prevent scientific information from being translated into sustainable energy practices. We discuss what we have learnt and close by briefly considering how our learnings might help avoid perpetrating similar fantasies of empowerment when scientific texts are exchanged at the academy-societal interface. In doing so, we link our work to this ICA panel’s theme which focuses on open science.
Could the acarid mite Tyrophagus putrescentiae (Schrank) be used as an environmental thermometer?

ABSTRACT A proof-of-concept for the reconstruction of historical temperatures from museum collections of a commonly-occurring saprophagous mite is recounted. Technological readiness level 3 (TRL3) and TRL4 stage-gates were passed for a multiplex bioassay of ambient temperature using re-purposed laboratory data of setal and body sizes of female Tyrophagus putrescentiae (Acaridae: Astigmata) individuals. Higher temperatures yielded smaller mites with shorter setae. Partial predictive utility of environmental temperature using a composite scale measure was found for mites field-collected in the UK ( TRL5 validation of use). Tyrophagid size in the wild appears individually variable and confounded in the cooler seasons through possible local heating effects (perhaps by virtue of their presence in numbers). Mite shape may change seasonally. Geographically dispersed detailed data-logging of micro-temperatures in the field together with targeted collection and characterization of mites at the same locations and measures of their local density is needed in order to advance such biotechnology to any demonstration of effective use all year round ( TRL6) and final use in museum research.
Conformational adaptation and manipulation of manganese tetra(4-pyridyl)porphyrin molecules on Cu(111)

Porphyrins are highly flexible molecules and well known to adapt to their local environment via conformational changes. We studied the self-assembly of manganese meso-tetra(4-pyridyl)porphyrin (Mn-TPyP) molecules on a Cu(111) surface by low temperature scanning tunneling microscopy (STM) and atomic force microscopy (ATM). We observe molecular chains along the ⟨11¯0⟩ direction of the substrate. Within these chains, we identify two molecular conformations, which differ by the orientation of the upward bending of the macrocycle. Using density functional theory, we show that this saddle shape is a consequence of the rotation and inclination of the pyridyl groups towards Cu adatoms, which stabilize the metal-organic chains. The molecular conformations obey a strict alternation, reflecting the mutual enforcement of conformational adaptation in densely packed structures. Tunneling electrons from the STM tip can induce changes in the orientation of the pyridyl endgroups. The switching behaviour varies with the di.
The Contribution of AI for SPOCs in Language Learning. The Example of SPOC+

The lightning speed of the progress in communication and teaching technologies and the emergence of mobile artefacts offers us the opportunity to propose a teaching system of the French language through natural language processing tools in a modular way. Being able to integrate the technologies of artificial intelligence adapted to teaching in the continuity of the MIRTO project, to allow the creation of a platform for 100% distance learning through Small Private Online Course for different levels of learners for learning French as a foreign language.
A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

Bisphosphonates (BPs) are a mainstay of osteoporosis treatment; however, concerns about bone health based on oversuppression of remodeling remain. Long‐term bone remodeling suppression adversely affects bone material properties with microdamage accumulation and reduced fracture toughness in animals and increases in matrix mineralization and atypical femur fractures in patients. Although a “drug holiday” from BPs to restore remodeling and improve bone quality seems reasonable, clinical BPs have long functional half‐lives because of their high hydroxyapatite (HAP) binding affinities. This places a practical limit on the reversibility and effectiveness of a drug holiday. BPs with low HAP affinity and strong osteoclast inhibition potentially offer an alternative approach; their antiresorptive effect should reverse rapidly when dosing is discontinued. This study tested this concept using NE‐58025, a BP with low HAP affinity and moderate osteoclast inhibition potential. Young adult female C57Bl/6 mice were ovariectomized (OVX) and treated with NE‐58025, risedronate, or PBS vehicle for 3 months to test effectiveness in preventing long‐term bone loss. Bone microarchitecture, histomorphometry, and whole‐bone mechanical properties were assessed. To test reversibility, OVX mice were similarly treated for 3 months, treatment was stopped, and bone was assessed up to 3 months post‐treatment. NE‐58025 and RIS inhibited long‐term OVX‐induced bone loss, but NE‐58025 antiresorptive effects were more pronounced. Withdrawing NE‐58025 treatment led to the rapid onset of trabecular resorption with a 200% increase in osteoclast surface and bone loss within 1 month. Cessation of risedronate treatment did not lead to increases in resorption indices or bone loss. These results show that NE‐58025 prevents OVX‐induced bone loss, and its effects reverse quickly following cessation treatment in vivo. Low‐HAP affinity BPs may have use as reversible, antiresorptive agents with a rapid on/off profile, which may be useful for maintaining bone health with long‐term BP treatment. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Characterization of Primary Cilia in Osteoblasts Isolated From Patients With ADPKD and CKD

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of chronic kidney disease (CKD) and leads to a specific type of bone disease. The primary cilium is a major cellular organelle implicated in the pathophysiology of ADPKD caused by mutations in polycystin‐1 (PKD1) and polycystin‐2 (PKD2). In this study, for the first time, cilia were characterized in primary preosteoblasts isolated from patients with ADPKD. All patients with ADPKD had low bone turnover and primary osteoblasts were also obtained from patients with non‐ADPKD CKD with low bone turnover. Image‐based immunofluorescence assays analyzed cilia using standard markers, pericentrin, and acetylated‐α‐tubulin, where cilia induction and elongation were chosen as relevant endpoints for these initial investigations. Osteoblastic activity was examined by measuring alkaline phosphatase levels and mineralized matrix deposition rates. It was found that primary cilia can be visualized in patient‐derived osteoblasts and respond to elongation treatments. Compared with control cells, ADPKD osteoblasts displayed abnormal cilia elongation that was significantly more responsive in cells with PKD2 nontruncating mutations and PKD1 mutations. In contrast, non‐ADPKD CKD osteoblasts were unresponsive and had shorter cilia. Finally, ADPKD osteoblasts showed increased rates of mineralized matrix deposition compared with non‐ADPKD CKD. This work represents the first study of cilia in primary human‐derived osteoblasts from patients with CKD and patients with ADPKD who have normal kidney function, offering new insights as bone disease phenotypes are not well recapitulated in animal models. These data support a model whereby altered cilia occurs in PKD‐mutated osteoblasts, and that ADPKD‐related defects in bone cell activity and mineralization are distinct from adynamic bone disease from patients with non‐ADPKD CKD. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.
The relationship of vitamin D deficiency with severity and outcome of acute stroke

Abstract Background. There are currently conflicting results regarding the link between vitamin D deficiency and the increased risk for stroke and its poor prognosis. The present study aimed to assess the relationship between vitamin D deficiency and prognosis of acute stroke. Methods. This bi-center cross-sectional study was performed on 140 consecutive patients who referred to two general hospitals in Iran with the diagnosis of acute stroke. The levels of 25-hydroxy vitamin D were evaluated by Electrochemiluminescence (ECL) technique. Clinical severity of stroke on admission as well as on discharge time were evaluated using the National Institutes of Health Stroke Scale (NIHSS) or Modified Rankin (mRS) tools. Results. Mean serum level of vitamin D was 25.51 ± 18.87 ng/mL, ranging from 3.0 to 98.6 ng/ml. There was a significant difference between the two groups (with and without vitamin D deficiency) in terms of stroke severity and disability, as reflected by mRS (P=0.003) and NIHSS evaluation (14.24 ± 9.23 versus 9.73 ± 7.36, P=0.003). Also, regarding patients’ clinical condition, the mean NIHSS score in those with deficient and normal levels of vitamin D was 14.24 ± 9.23 and 9.73 ± 7.36, respectively with NIHSS score > 5 in 76.1% and 61.5%, respectively (P = 0.003). Conclusion. According to the results of study, vitamin D status can be related to the severity of stroke. However, considering the cross-sectional design of our study, it could not point out the causality between vitamin D deficiency and acute stroke and further studies are warranted. It is not possible to draw any conclusions in terms of causality. Further studies are required in order to assess the relationship between the serum vitamin D levels and stroke severity.
Foliar applications of plant-based titanium dioxide nanoparticles to improve agronomic and physiological attributes of wheat (Triticum aestivum L.) plants under salinity stress

Abstract The present study was carried out to investigate the beneficial and toxicological effect of plant-based titanium dioxide nanoparticles (TiO2 NPs) on the morphophysiological attributes of wheat plants under salinity stress. The biogenesis of titanium dioxide nanoparticles was accomplished by using the extract of Buddleja asiatica L. leaves followed by characterization through UV visible spectroscopy, SEM, FTIR, and EDX. NaCl salt was applied in two different concentrations after 21 days of germination followed by foliar applications of various concentrations of TiO2 NPs (20, 40, 60, 80 mg/L) to salinity-tolerant (Faisalabad-08) and salinity-susceptible (NARC-11) wheat varieties after 10–15 days of application of salt stress. Salinity stress showed remarkable decrease in morphophysiological attributes of selected wheat varieties. Magnificent improvement in plant height, dry and fresh weight of plants, shoot and root length, root and shoot fresh and dry weight, number of leaves per plant, RWC, MSI, chlorophyll a and b, and total chlorophyll contents has been observed when 40 mg/L of TiO2 NPs was used. However, the plant morphophysiological parameters decreased gradually at higher concentrations (60 and 80 mg/L) in both selected wheat varieties. Therefore, 40 mg/L concentration of TiO2 NPs was found most preferable to increase the growth agronomic and physiological attributes of selected wheat varieties under salinity.
Di ↵ erentially Private Analysis on Graph Streams

In this paper, we focus on answering queries, in a di ↵ erentially private manner, on graph streams. We adopt the sliding window model of privacy, where we wish to perform analysis on the last W updates and ensure that privacy is preserved for the entire stream. We show that in this model, the price of ensuring di ↵ erential privacy is minimal. Furthermore, since di ↵ erential privacy is preserved under post-processing, our results can be used as a subroutine in many tasks, most notably solving cut functions and spectral clustering.
Semi-Supervised Aggregation of Dependent Weak Supervision Sources With Performance Guarantees

We develop a novel method that provides theoretical guarantees for learning from weak labelers without the (mostly unrealistic) assumption that the errors of the weak label-ers are independent or come from a particular family of distributions. We show a rigorous technique for eﬃciently selecting small subsets of the labelers so that a majority vote from such subsets has a provably low error rate. We explore several extensions of this method and provide experimental results over a range of labeled data set sizes on 45 image classiﬁcation tasks. Our performance-guaranteed methods consistently match the best performing alternative, which varies based on problem diﬃculty. On tasks with accurate weak labelers, our methods are on average 3 percentage points more accurate than the state-of-the-art adversarial method. On tasks with inaccurate weak labelers, our methods are on average 15 percentage points more accurate than the semi-supervised Dawid-Skene model (which assumes independence).
Principal Subspace Estimation Under Information Diffusion

Let A = L 0 + S 0 , where L 0 ∈ R d × d is low rank and S 0 is a perturbation matrix. We study the principal subspace estimation of L 0 through observations y j = f ( A ) x j , j = 1 , . , n , where f : R → R is an unknown polynomial and x j ’s are i.i. d. random input signals. Such models are widely used in graph signal processing to model information diﬀusion dynamics over networks with applications in network topology inference and data analysis. We develop an estimation procedure based on nuclear norm penalization, and establish upper bounds on the principal subspace estimation error when A is the adjacency matrix of a random graph generated by L 0 . Our theory shows that when the signal strength is strong enough, the exact rank of L 0 can be recovered. By applying our re-sults to blind community detection, we show that consistency of spectral clustering can be achieved for some popular stochastic block models. Together with the experimental re-sults, our theory show that there is a fundamental limit of using the principal components obtained from diﬀused graph signals which is commonly adapted in current practice. Finally, under some structured perturbation S 0 , we build the connection between this model with spiked covariance model and develop a new estimation procedure. We show that such estimators can be optimal under the minimax paradigm.
Rostral Intralaminar Thalamus Engagement in Cognition and Behavior

The thalamic rostral intralaminar nuclei (rILN) are a contiguous band of neurons that include the central medial, paracentral, and central lateral nuclei. The rILN differ from both thalamic relay nuclei, such as the lateral geniculate nucleus, and caudal intralaminar nuclei, such as the parafascicular nucleus, in afferent and efferent connectivity as well as physiological and synaptic properties. rILN activity is associated with a range of neural functions and behaviors, including arousal, pain, executive function, and action control. Here, we review this evidence supporting a role for the rILN in integrating arousal, executive and motor feedback information. In light of rILN projections out to the striatum, amygdala, and sensory as well as executive cortices, we propose that such a function enables the rILN to modulate cognitive and motor resources to meet task-dependent behavioral engagement demands.