Miracle-dz/UniFAR-FTUs huggingface dataset:
Confinement effectiveness of 2900psi concrete using the extract of Euphorbia tortilis cactus as a natural additive

Concrete with cactus is a new type of concrete with high fluidity, strength, and durability with more remarkable advantages. The present paper discusses the role of Euphorbia tortilis cactus (ETC) to achieve the strength, durability, and corrosion resistance properties of concrete specimens. In this work, M 20 (2900psi) concrete was designed as per Indian standards, and cactus were used as an additive. ETC extracts from Tamilnadu (India) were replaced with water (1%, 3%, 5%, 7%, 9%) by weight. The performance of cactus concrete was analyzed through destructive and non-destructive tests to investigate strength properties. In addition to that, specific tests such as sorptivity, permeability, half-cell potential test, etc. have been performed further for durability and corro - sion resistance. ETC concrete improves the fluidity, thereby enhancing the workability of the mixture. Concrete was analyzed through Scanning Electron Microscopy (SEM) to identify the particle distribution. Experimental investigation shows that the strength properties of concrete have been enhanced by 29% due to Polysaccharides at optimum level. However, durability is achieved at a high, which stimulates the effective filling of voids in concrete. It shows that better performance of concrete gives at optimum dosage. On Euphorbia tortilis cactus concrete, no literature has been discovered.
Picotesla field sensor design using spin-dependent tunneling devices

Pinned spin-dependent tunneling devices were fabricated and tested in a mode suited for low-field sensing. The basic structure of the devices was NiFeCo125/Al2O325/CoFe70/Ru9/CoFe70/ FeMn125 (in A). This structure had a tunneling resistivity of 110 MΩ μm2 and exhibited a 20% magnetoresistance when a field was swept along the easy direction of the soft electrode. High sensitivity, low hysteresis operation was achieved by applying a bias field orthogonal to the easy axis. A sensitivity of 3%/Oe with negligible hysteresis was observed using this mode of operation. A sensor using this type of material was designed to achieve a minimum resolvable field in the picotesla range. The sensor consists of a bridge with four elements, each having 16 tunnel junctions in series. A signal-to-noise ratio of 1:1 at 1 pT (10−8 Oe) is possible assuming achievable values for the tunneling resistivity, device size, bias level, and sensitivity.
Detection of Necrosis in Digitised Whole-Slide Images for Better Grading of Canine Soft-Tissue Sarcomas Using Machine-Learning

Simple Summary Canine soft-tissue sarcomas are a group of tumours that arise from the skin and subcutaneous connective tissue. The most common method used to predict the behaviour of these tumours is grading. The grading system used for soft-tissue sarcomas is derived from a combined score calculated by evaluating the mitotic count, percentage of tumour necrosis and degree of cellular differentiation. However, these parameters are highly subjective and a high inter-observer variability has been reported in grading these tumours, which can result in complications regarding treatment plans. Manual identification of areas of necrosis is a time-consuming task that is prone to observer error. Artificial-intelligence algorithms and, in particular, machine learning, can help improve grading by automatically detecting regions of necrosis. The aim of this study was to differentiate image regions in order to automatically identify tumour necrosis in digitised canine soft-tissue sarcoma slides. This method showed an accuracy of 92.7% which represents the number of correctly classified data instances over the total number of data instances. Therefore, the proposed method is a promising tool to minimise human error in the evaluation of necrosis in soft-tissue sarcomas, and hence increase the efficiency and accuracy of histopathological grading of canine soft-tissue sarcomas. Abstract The definitive diagnosis of canine soft-tissue sarcomas (STSs) is based on histological assessment of formalin-fixed tissues. Assessment of parameters, such as degree of differentiation, necrosis score and mitotic score, give rise to a final tumour grade, which is important in determining prognosis and subsequent treatment modalities. However, grading discrepancies are reported to occur in human and canine STSs, which can result in complications regarding treatment plans. The introduction of digital pathology has the potential to help improve STS grading via automated determination of the presence and extent of necrosis. The detected necrotic regions can be factored in the grading scheme or excluded before analysing the remaining tissue. Here we describe a method to detect tumour necrosis in histopathological whole-slide images (WSIs) of STSs using machine learning. Annotated areas of necrosis were extracted from WSIs and the patches containing necrotic tissue fed into a pre-trained DenseNet161 convolutional neural network (CNN) for training, testing and validation. The proposed CNN architecture reported favourable results, with an overall validation accuracy of 92.7% for necrosis detection which represents the number of correctly classified data instances over the total number of data instances. The proposed method, when vigorously validated represents a promising tool to assist pathologists in evaluating necrosis in canine STS tumours, by increasing efficiency, accuracy and reducing inter-rater variation.
Analysis of Optical Wireless Communication Links in Turbulent Underwater Channels With Wide Range of Water Parameters

In this study, the performance of underwater optical wireless communication links is investigated by taking into account turbulence, absorption and scattering effects. Weak turbulent channel is modeled using log-normal distribution while moderate and strong turbulence channels are modeled using gamma-gamma distribution. Rytov variance of Gaussian beam is derived analytically for oceanic turbulence optical power spectrum. Subsequently, scintillation index is calculated using the computed Rytov variance. Moreover, the closed-form expression of bit-error-rate (BER) for underwater wireless optical communication (UWOC) systems using intensity-modulated/direct detection (IM/DD) implementation and on-off-keying (OOK) modulation scheme is obtained. Results show that the performance of wireless optical communication link between two platforms in underwater medium is degraded significantly due to turbulence, absorption and scattering. In fact, as the turbulence level increases, its effect becomes quantitatively comparable to those of absorption and scattering effects. The variation of both scintillation index and BER performance are presented for various underwater medium and communication system parameters, such as chlorophyll concentration, average temperature, average salinity concentration, temperature and dissipation rates, wavelength, link length and receiver aperture size. Optical network and internet of underwater things (IoUT) applications, which are growing day by day and requiring high data rates, will benefit from the results of this study.
Is the 4C Score Still a Valid Item to Predict In-Hospital Mortality in People with SARS-CoV-2 Infections in the Omicron Variant Era?

Since the start of the SARS-CoV-2 pandemic, several scores have been proposed to identify infected individuals at a higher risk of progression and death. The most famous is the 4C score. However, it was developed in early 2020. Our study aimed to evaluate the accuracy of the 4C score during the wave in which the Omicron variant was prevalent. An observational study was conducted at an Italian University Hospital between 1 January and 31 July 2022. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the ability of the 4C score to predict mortality. Overall, 1186 people were recruited, of which 160 (13.5%) died. According to the 4C score, 177 (11.6%) were classified as having a low risk of mortality, 302 (25.5%) were intermediate, 596 (50.3%) were high, and 151 (12.7%) were very high. The ROC curve of the 4C score showed an AUC (95% CI) value of 0.78 (0.74–0.82). At the criterion value of > 10, the sensitivity was 76.2% and the specificity was 62.67%. Similar to previous studies, the 4C mortality score performed well in our sample, and it is still a useful tool for clinicians to identify patients with a high risk of progression. However, clinicians must be aware that the mortality rate reported in the original studies was higher than that observed in our study.
Comparison of deep and combined serratus anterior plane block after video-assisted thoracoscopic surgery; a prospective randomized trial

Aim: Ultrasound-guided plane blocks have been employed frequently in Video-assisted thoracoscopic surgery (VATS). The aim of this study was to evaluate the effect of deep and combined serratus anterior plane block (SAPB) after VATS. Material and Method: The patients, in the age range of 18 to 65 years, with the American Society of Anesthesiologists (ASA) physical status of I-III, and body mass index (BMI) of 18-30 kg/m2, and undergoing lung resection with VATS were included in the study. Patients were informed about the study, and their written consent was obtained. Patients were divided into Deep SAPB (DSAPB) (Group 1) and combined SAPB (CSAPB) (Group 2) groups according to the analgesia protocol. Results: There was no statistically significant difference between the groups in terms of demographic characteristics and surgical features (p > 0.05). When the groups were evaluated in terms of the block performance time, it was found to be statistically significantly longer in the CSAPB group than in the DSAPB group (p < 0.001). When the groups were evaluated in terms of VAS resting scores, the 1st, 2nd, 4th, 8th, and 16th, 24th, and 48th-hour VAS resting results were found to be statistically significantly higher in the DSAPB group than the CSAPB group (p < 0.05). VAS cough scores were statistically significantly higher in the DSAPB group at the 1st, 2nd, 4th, 8th, and 16th, 24th, and 48th-hour (p < 0.05). When the groups were evaluated in terms of the side effects, additional analgesic use, and morphine consumption, they were found to be statistically significantly higher in the DSAPB group than in the CSAPB group (p: 0.026, p: 0.020, p < 0.001, respectively). Conclusion: CSAPB provided effective analgesia after VATS for 48 hours. In addition, morphine consumption and the need for additional analgesics were low in CSAPB. However, the duration of the block procedure was longer in the CSAPB application.
Stability of non-autonomous population models with bounded and periodic enforcement

The paper presents theorems on the global asymptotic behaviour of non-autonomous population models which for the special case of periodically forced populations generalize known results. It is shown that a non-autonomous discrete dynamical system on an interval possesses the property of path stability, if the system is given by cave functions. From this it follows for a periodic system with strictly cave functions that there exists a globally asymptotically stable cycle. Old and new examples are discussed.
DYNAMIC PROPERTIES OF INTERSTITIAL CARBON AND CARBON-CARBON PAIR DEFECTS IN SILICON

Interstitial carbon, ${\mathrm{C}}_{\mathrm{i}}$, defects in Si exhibit a number of unexplained features. The ${\mathrm{C}}_{\mathrm{i}}$ defect in the neutral charge state gives rise to two almost degenerate vibrational modes at 920 and 931 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ whose 2:1 absorption intensity ratio naturally suggests a trigonal defect in conflict with uniaxial stress measurements. The dicarbon, ${\mathrm{C}}_{\mathrm{s}}$-${\mathrm{C}}_{\mathrm{i}}$, defect is bistable, and the energy difference between its A and B forms is surprisingly small even though the bonding is very different. In the B form appropriate to the neutral charge state, a silicon interstitial is believed to be located near a bond-centered site between two ${\mathrm{C}}_{\mathrm{s}}$ atoms. This must give rise to vibrational modes which involve the motion of both C atoms in apparent conflict with the results of photoluminescence experiments. We use an ab initio local density functional cluster method, AIMPRO, to calculate the structure and vibrational modes of these defects and find that the ratio of the absorption intensities of the local modes of ${\mathrm{C}}_{\mathrm{i}}$ is in reasonable agreement with experiment even though the structure of the defect is not trigonal. We also show that modes in the vicinity of those detected by photoluminescence for the B form of the dicarbon center involve independent movements of the two C atoms. Finally, the trends in the relative energies of the A and B forms in three charge states are investigated.
Estimation of the Moment Generating Function

A number of statistical problems use the moment generating function (mgf) for purposes other than determining the moments of a distribution. If the distribution is not completely specified, then the mgf must be estimated from available data. The empirical mgf makes no assumptions concerning the underlying distribution except for the existence of the mgf. In contrast to the nonparametric approach provided by the empirical mgf, alternative estimators can be formed based on an assumed parametric model. Comparison of these approaches is considered for two parametric models; the normal and a one parameter gamma. Comparison criteria are efficiency and empirical confidence interval coverage. In general the parametric estimators outperform the empirical mgf when the model is correct. The comparisons are extended to underlying models which are two component mixtures from the distributional family assumed by the parametric estimators. Under the mixture models the superiority of the parametric estimator depends upon.
On the nature of the bipolar molecular outflow in AFGL 437

With the IRAM 30 m telescope we have observed the CO(J=2→1), 13 CO(J=1→0), and C 18 O(J=1→0) rotational transition lines toward the AFGL 431 cluster. Our data show a molecular outflow with a north-south bipolarity. This bipolarity is observed in the three lines. An interesting result is that the blue and redshifted lobes are not elongated in the direction of the outflow axis, but in the east-west direction, perpendicularly to the outflow axis. Therefore, AFGL 431 appears to be an outflow with a clear bipolarity, but with a very low collimation
THE EFFECT OF SHOPPING LIFESTYLE AND FASHION INVOLVEMENT ON IMPULSE BUYING BEHAVIOR

Impulse buying is a buying decision by consumers spontaneously shortly after seeing a product offer, nowadays people are increasingly making impulse purchases because of their lifestyle, especially in fashion products. Retailers must understand the phenomenon and study the factors causing it so as to be able to maximize it, to be able to attract consumers to make impulse buying. This study aims to determine the effect of shopping lifestyle and fashion involvement on impulse buying behavior. The form of this research is quantitative research with an associative approach. The population in this study were consumers of Delipark Mall Medan with a sample of 100 people. The data collection technique was carried out with primary data with questionnaires through google form. The results of this study indicate that shopping lifestyle and fashion involvement have a significant effect on impulse buying behavior. In simultaneous testing, the shopping lifestyle and fashion involvement variables have a simultaneous effect on impulse buying behavior, with the magnitude of the relationship between the Shopping Lifestyle and Fashion Involvement variables on the Impulse Buying Behavior variable of 0.561, with a fairly close category. While the remaining 30% is influenced by other variables beyond this study.
Enhancement of Color Brightness on Clown Fish (Amphiprion percula) With Addition of Tomato Powder Extract

The prospect of clown fish cultivation business is still being expanded to make profitable business activities and increasingly attract ornamental fish lovers. However, it is difficult to get clown fish with a good level of color brightness. So it can reduce the level of sales production. This study aims to determine the effect of the addition of tomato powder to increase the brightness of the color clown fish at the Ambon Marine Aquaculture Fisheries Center. The research was conducted from March to June 2020 at the Ambon Marine Aquaculture Fisheries Center. This study used a Completely Randomized Design (RAL) with 4 treatments and 3 replications. The treatment is to mix tomato powder in the feed with a concentration of 0 mg/gr (Treatment A), concentration 20 mg/gr (Treatment B), concentration 40 mg/gr (Treatment C), and concentration 60 mg/gr (Treatment D). The fish used is a clown fish with a size of 1 cm with a spread of 4 fish with a circulatory maintenance system. The observed parameters include the brightness of the clown fish color, which is measured using the color grab camera app, the growth of which is the average length and weight of average seeds measured using a ruler with a precision rate of 1 cm and a digital scale with a precision rate of 0.01gr and survival rate. The results showed that feeding with the addition of powdered tomato did not give a significant effect to increase the brightness of the color of the clown fish. However, it affects the growth (length and weight) and survival rate of clownfish seeds.
Evaluation of Human Papilloma Virus (HPV) Genotyping and Viral Load Determination as Diagnostic Biomarkers of Cervical Cancer Risk

HPV testing in cervical cancer screening programs offers the possibility of introducing molecular standardized biomarkers for the triage of HPV-positive women. This study aimed to evaluate the role of HPV genotyping and viral load as possible diagnostic biomarkers of high-grade cervical lesions (CIN2+) by performing a preliminary evaluation of a new HPV test. Cervical specimens were obtained from 200 women referred for a colposcopy. Samples were tested using both Anyplex™ II HR-HPV as well as OncoPredict HPV® Screening (SCR) and quantitative typing (QT). Using a cycle threshold cutoff (Ct) of 36.8 for the SCR assay and 1.27 log10 (viral copies/104 cells) for the QT assay, relative clinical sensitivity for CIN2+ and relative clinical specificity for CIN2− as compared to Anyplex™ II HR-HPV were, respectively, 0.92 and 1.00 for SCR and 1.35 and 1.24 for QT. The distribution of high-risk HPV (HR-HPV) genotypes (p = 0.009) as well as the viral copy numbers (CIN2−: 3.7 log10 (viral copies/104 human cells); CIN2+: 4.3 log10 (viral copies/104 human cells); p = 0.047) were found to differ in women with high- and low-grade cervical lesions, suggesting a possible role of HPV genotyping and normalized viral load as potential biomarkers to identify women at increased risk of cervical lesions.
Safety and Evaluation of the Immune Response of Coronavirus Nosode (BiosimCovex) in Healthy Volunteers: A Preliminary Study Extending the Homeopathic Pathogenetic Trial

Objectives: Regulatory clinical Phase I studies are aimed at establishing the human safety of an active pharmaceutical agent to be later marketed as a drug. Since homeopathic medicines are prepared by a potentizing method using alcohol, past a certain dilution, their toxicity/infectivity is assumed to be unlikely. We aimed to develop a bridge study between homeopathic pathogenetic trials and clinical trials. The primary purpose was to evaluate the safety of a nosode, developed from clinical samples of a COVID-19 patient. The secondary objectives were to explore whether a nosode developed for a specific clinical purpose, such as use during an epidemic, may elicit laboratory signals worthy of further exploration. Methods: An open-label study was designed to evaluate the safety and immune response of the Coronavirus nosode BiosimCovex, given orally on three consecutive days to ten healthy volunteers. Clinical examinations, laboratory safety and immune parameters were established. Interferon–gamma, Interleukin-6, and CD 4 were measured. (CTRI registration number: CTRI/2020/05/025496). Results: No serious/fatal adverse events were reported. Laboratory tests to measure safety were unchanged. Three subjects showed elevated Interleukin-6 (IL-6) on day 17 in comparison to the baseline, and ten subjects showed elevated IL-6 on day 34. A significant difference between IL-6 observations, calculated by repeated measures ANOVA, was found to be highly significant. On day 60, the IL-6 values of nine subjects were found to return to normal. Corresponding CD4 cell elevation was observed on day 60, when compared to day 34. Conclusions: HPT may potentially extend into physiological changes with regards to immune response and should encourage future studies.
Real-Life Effectivity of Dose Intensity Reduction of First-Line mFOLFIRI-Based Treatment of Metastatic Colorectal Cancers: Sometimes Less Is More

Aim: The key purposes of the treatment of metastatic malignancies are to extend survival and maintain the quality of life. Recently it has been emphasized in the scientific literature that the maintenance of maximal dose intensity is not always beneficial. Method: We examined the effectiveness of first-line mFOLFIRI-based treatments used in mCRC indication in 515 patients, treated between 1 January 2013 and 31 December 2018 at the Department of Oncotherapy of the University of Pécs, on a basis of real-world retrospective data analysis. We studied the effect of decreased dose intensity treatment modifications on patient survival. Results: 45% of all patients achieved the optimal relative dose intensity (RDI) of 85%, and the median progression-free and overall survival (mPFS, mOS) were 199 and 578 days, compared to 322 and 743 days, (mPFS p < 0.0002, 1 y (year) PFS OR (odds ratio) 0.39 (95% CI: 0.26–0.56) and mOS p = 0.0781, 2 yrs OS OR 0.58 (95% CI: 0.39–0.85), respectively) in the group of patients not achieving the RDI of 85%. Conclusions: Decreased dose intensity did not reduce the effectiveness of treatment; in fact, there was a significant improvement in most of the analyzed parameters. The option of reduced dose intensity, which shows the same or even better results with less toxicity, should definitely be considered in the future palliative treatment of mCRC patients.
Possible presence of a charge-orbital density wave in layered manganites Nd1-xCa1+xMnO4

We have studied the structural modifications related to the charge-orbital ordering for single-layered manganites ${\mathrm{Nd}}_{1\ensuremath{-}x}{\mathrm{Ca}}_{1+x}{\mathrm{MnO}}_{4}$ with both commensurate and incommensurate doping levels $(0.55\ensuremath{\leqq}x\ensuremath{\leqq}0.75). $ High-resolution electron microscopy (HREM) revealed transverse and sinusoidal structural modulations with a doping-level-dependent period of ${d}_{s}=a/(1\ensuremath{-}x)$ in the charge-orbital ordered phases. We discuss the possibility of an orbital-density wave as well as a charge-density wave based on the HREM observation of the single-layered manganites.