Miracle-dz/UniFAR-FTUs huggingface dataset:
Inversion of near-field waveform data for earthquake source rupture process (I): Method and numerical test

A new inversion algorithm for simultaneously reconstructing the slip vectors and rupture times of a propagating finite fault is developed based on the recent progress in the nonlinear programming study. To check the validity of this new inversion algorithm, several numerical tests are conducted. The results show that this new source rupture process inversion algorithm is computationally efficient and numerically stable, and depends less on the initial model compared with the two popular inversion methods, i.e. the linear matrix method and the global stochastic search method. Therefore, this new inversion algorithm is expected to be useful in inverting earthquake rupture processes.
Patient and Provider Decision Making About HIV Postexposure Prophylaxis Following Sexual Violence: A Qualitative Analysis

Abstract To explore patient and health care provider HIV postexposure prophylaxis (PEP) decision making following sexual assault, semistructured interviews regarding HIV PEP provision with 15 patients and 10 health care providers were conducted. A qualitative, descriptive, thematic analysis approach was used. Four themes were derived: (a) medical concerns; (b) emotional, trauma, and support factors; (c) daily medication management; and (d) ensuring access to HIV PEP. How participants described these themes and the importance placed on factors within each theme varied between the two groups. Altering provider communication so that HIV PEP discussions better align with patient decision-making factors (e.g., trauma and ability to take in information, how to manage side effects) could facilitate improvement in HIV PEP decision making following sexual assault for patients. High-level policy changes would improve HIV PEP access for sexual assault patients without necessitating the extraordinary efforts individual providers currently undertake.
Fetal sex and the development of gestational diabetes mellitus in gravidae with multiple gestation pregnancies

There is an increasing incidence of pregnancies with twin gestations. One outcome more likely to occur with multiple gestations is gestational diabetes mellitus. Studies have suggested that in singleton pregnancies, fetal sex may affect insulin resistance. However, the effects of fetal sex in twins and the development of gestational diabetes mellitus are unknown. We hypothesized that rates of gestational diabetes mellitus and degree of insulin resistance might vary in twin gestations based on the fetal sex pairing: male–male, male–female or female–female. We aimed to employ a large population‐based database to ascertain any correlations between fetal sex and gestational diabetes mellitus in multifetal gestations.
Advances in the reconstruction of the spider tree of life: A roadmap for spider systematics and comparative studies

In the last decade and a half, advances in genetic sequencing technologies have revolutionized systematics, transforming the field from studying morphological characters or a few genetic markers, to genomic datasets in the phylogenomic era. A plethora of molecular phylogenetic studies on many taxonomic groups have come about, converging on, or refuting prevailing morphology or legacy‐marker‐based hypotheses about evolutionary affinities. Spider systematics has been no exception to this transformation and the inter‐relationships of several groups have now been studied using genomic data. About 51 500 extant spider species have been described, all with a conservative body plan, but innumerable morphological and behavioural peculiarities. Inferring the spider tree of life using morphological data has been a challenging task. Molecular data have corroborated many hypotheses of higher‐level relationships, but also resulted in new groups that refute previous hypotheses. In this review, we discuss recent advances in the reconstruction of the spider tree of life and highlight areas where additional effort is needed with potential solutions. We base this review on the most comprehensive spider phylogeny to date, representing 131 of the 132 spider families. To achieve this sampling, we combined six Sanger‐based markers with newly generated and publicly available genome‐scale datasets. We find that some inferred relationships between major lineages of spiders (such as Austrochiloidea, Palpimanoidea and Synspermiata) are robust across different classes of data. However, several new hypotheses have emerged with different classes of molecular data. We identify and discuss the robust and controversial hypotheses and compile this blueprint to design future studies targeting systematic revisions of these problematic groups. We offer an evolutionary framework to explore comparative questions such as evolution of venoms, silk, webs, morphological traits and reproductive strategies.
Is that My Heartbeat? Measuring and Understanding Modality-Dependent Cardiac Interoception in Virtual Reality

Measuring interoception (‘perceiving internal bodily states’) has diagnostic and wellbeing implications. Since heartbeats are distinct and frequent, various methods aim at measuring cardiac interoceptive accuracy (CIAcc). However, the role of exteroceptive modalities for representing heart rate (HR) across screen-based and Virtual Reality (VR) environments remains unclear. Using a PolarH10 HR monitor, we develop a modality-dependent cardiac recognition task that modifies displayed HR. In a mixed-factorial design (N=50), we investigate how task environment (Screen, VR), modality (Audio, Visual, Audio-Visual), and real-time HR modifications (±15%, ±30%, None) influence CIAcc, interoceptive awareness, mind-body measures, VR presence, and post-experience responses. Findings showed that participants confused their HR with underestimates up to 30%; environment did not affect CIAcc but influenced mind-related measures; modality did not influence CIAcc, however including audio increased interoceptive awareness; and VR presence inversely correlated with CIAcc. We contribute a lightweight and extensible cardiac interoception measurement method, and implications for biofeedback displays.
PKMYT1 induced by YAP/TEAD1 gives rise to the progression and worse prognosis of bladder cancer

Protein kinase, membrane‐associated tyrosine/threonine 1 (PKMYT1), which is associated with progression of tumor, is upregulated in a variety of cancers. However, its expression and the underlying molecular mechanisms in the context of bladder cancer (BLCA) remain elusive. Here we found that PKMYT1 expression was markedly higher expression in BLCA, which was correlated with poorer prognosis compared with low expression. Knockdown of PKMYT1 significantly inhibited the BLCA cells proliferation in vivo and in vitro, and migration and invasion, reduced G2/M phase in cell cycle and induced apoptosis. Mechanically, YAP and TEAD1 knockdown suppressed PKMYT1 expression in BLCA cells, whereas overexpression of YAP upregulated PKMYT1 expression and YAP prompted PKMYT1 transcriptional expression via TEAD1‐mediated direct binding to PKMYT1 promotor. Collectively, these findings suggest that PKMYT1, functioning as a direct gene target regulated by YAP/TEAD1, could serve as a potential indicator of progression and prognosis in BLCA. Further, PKMYT1 could serve as a novel therapeutic target for BLCA.
Smart city perspectives of Bloemfontein, South Africa

To handle rapid urbanization, there is need to find new ways to manage complexity, increase efficiency, reduce expenses, and improve quality of life. The new ways are rooted in the concept of 'smart city'. The concept theorize that emerging technologies would shape urban environments in varying ways that would include but not limited to the economy, mobility, governance, and living conditions of a city. While this concept is now a reality in major cities in developed economies, this is not the case in South Africa and the region. Against this background, an evaluation of socio-economic and environmental capital of Bloemfontein has been used as a case example to demonstrate the transformational requirements for a 'smart city' in South Africa. The evaluation utilised 74 indicators, and 30 factors of six smart characteristics, which include economy, environment, governance, living and mobility. Reviewed literature and semi-structure surveys were used for the evaluation, which suggests that Bloemfontein is lagging behind concerning key development indicators. In particular, the evaluation indicates that the city lag performance relative to mobility, economy, people and living sector, although environment and governance features appear to be promising. An overall evaluation of the indicators and factors points to a major scope for the city to transform to a smart city, if plausible actions are taken.
Progress of actinolite‐forming reactions in mafic schists during retrograde metamorphism: an example from the Sanbagawa metamorphic belt in central Shikoku, Japan

Hydration reactions are direct evidence of fluid–rock interaction during regional metamorphism. In this study, hydration reactions to produce retrograde actinolite in mafic schists are investigated to evaluate the controlling factors on the reaction progress. Mafic schists in the Sanbagawa belt contain amphibole coexisting with epidote, chlorite, plagioclase and quartz. Amphibole typically shows two types of compositional zoning from core to rim: barroisite → hornblende → actinolite in the high‐grade zone, and winchite → actinolite in the low‐grade zone. Both types indicate that amphibole grew during the exhumation stage of the metamorphic belt. Microstructures of amphibole zoning and mass‐balance relations suggest that: (1) the actinolite‐forming reactions proceeded at the expense of the preexisting amphibole; and (2) the breakdown reaction of hornblende consumed more H2O fluid than that of winchite, when one mole of preexisting amphibole was reacted. Reaction progress is indicated by the volume fraction of actinolite to total amphibole, Yact, with the following details: (1) reaction proceeded homogeneously in each mafic layer; (2) the extent of the hornblende breakdown reaction is commonly low (Yact < 0.5), but it increases drastically in the high‐grade part of the garnet zone (Yact > 0.7); and (3) the extent of the winchite breakdown reaction is commonly high (Yact > 0.7). Many microcracks are observed within hornblende, and the extent of hornblende breakdown reaction is correlated with the size reduction of the hornblende core. Brittle fracturing of hornblende may have enhanced retrograde reaction progress by increasing of influx of H2O and the surface area of hornblende. In contrast to high‐grade rocks, the winchite breakdown reaction is well advanced in the low‐grade rocks, where reaction progress is not associated with brittle fracturing of winchite. The high extent of the reaction in the low‐grade rocks may be due to small size of winchite before the reaction.
Two-Dimensional Solution for Straight and Meandering Overbank Flows

This paper presents a practical method to predict depth-averaged velocity and shear stress for straight and meandering overbank flows. An analytical solution to the depth-integrated turbulent form of the Navier-Stokes equation is presented that includes lateral shear and secondary flows in addition to bed friction. The novelty of the present approach is not only its inclusion of the secondary flows in the formulation but also its applicability to straight and meandering channels. The analytical solution is applied to a number of channels, at model and field scales, and is also compared with other available methods such as that of Shiono and Knight and the lateral distribution method. The present formulation gives much better predictions of velocity and shear stress, particularly in those cases where the secondary flows are dominant.
Seasonal and bleaching‐induced changes in coral reef metabolism and CO2 flux

Monitoring seawater CO2 for a full year with seasonal observations of community metabolism in Ishigaki Island, Japan, revealed seasonal variation and anomalous values owing to the bleaching event in 1998. The daily average pCO2 showed a seasonal pattern on an annual scale, 280 to 320 μatm in winter and 360 to 400 μatm in summer, which was determined primarily by the seasonal change in seawater temperature. By contrast, the range in the diel variation in pCO2, 400 to 500 μatm in summer 200 to 300 μatm in winter, was attributed to the seasonal variation in community metabolism: Gross primary production (Pg) and respiration (R) were high in summer and low in winter. During the 1998 bleaching event, although Pg and R increased, community excess organic production (E) decreased by three quarters compared with the same month in 1999, when the coral community showed high recovery. This change in metabolism led to large diel range and increased average value of pCO2 levels in the seawater on the reef flat. The decrease in the range and increase in the average value of pCO2 were observed by monitoring the Palau barrier reef flat, where overall mortality of corals occurred after the bleaching. All the metabolic parameters, Pg, R, E and calcification (G) were reduced by half after the bleaching, which increased the average pCO2 value by 10 μatm and decreased its diel range from 200–400 μatm to 100–200 μatm. Bleaching and resultant mortality of coral reefs led to degradation of their metabolic performance, and thus resulted in the loss of their active interaction with the carbon cycle.
Individualized chemotherapy drug dose escalation in dogs with multicentric lymphoma

Abstract Background This study was performed to determine the ability to escalate drug doses in a 15‐week CHOP protocol in dogs with multicentric lymphoma. Hypothesis We hypothesized that at least 50% of dogs could successfully be escalated in at least 1 drug. Secondary aims were to establish objective response rate (ORR), progression‐free interval (PFI), and overall survival time (OST). Animals Thirty dogs with newly diagnosed multicentric lymphoma were prospectively treated with a 15‐week CHOP protocol. Methods This was a prospective cohort study. Drug doses that did not cause dose‐limiting adverse effects (AEs) were increased using a standardized escalation protocol. AEs and response were assessed using VCOG criteria. Serial blood samples were collected after the first dose of each drug for pharmacokinetic analysis. Results Of the 23 dogs with the opportunity to dose escalate, at least 1 drug was successfully escalated in 18 (78%). Vincristine was successfully escalated to 0.8 mg/m2 or higher in 11 dogs, cyclophosphamide to 300 mg/m2 or higher in 16 dogs, and doxorubicin to 35 mg/m2 or 1.4 mg/kg or higher in 9 dogs. Three of the 23 dogs (13%) were hospitalized at least once because of drug‐induced AEs. Neutropenia was the most common dose‐limiting toxicosis for all drugs. Peak doxorubicin concentrations were significantly lower in dogs where doxorubicin was successfully escalated. The objective response rate was 100%. The median progression free interval was 171 days. The median overall survival time was 254 days. Conclusions Drugs in the CHOP protocol can often be escalated safely with manageable AEs.
Eriocitrin inhibits epithelial-mesenchymal transformation (EMT) in lung adenocarcinoma cells via triggering ferroptosis

Introduction: Lung adenocarcinoma (LUAD) is the most prevalent pathological subtype of non-small cell lung cancer (NSCLC), characterized by a high propensity for relapse and metastasis due to epithelial-mesenchymal transition (EMT) of cancer cells. Ferroptosis, a newly discovered regulated cell death modality, is interconnected with the EMT process in certain cancers. Eriocitrin, a natural flavonoid compound, exerts anti-inflammatory and anticancer effects. Objectives: The aim of this study is to investigate the potential inhibitory effect of eriocitrin on lung adenocarcinoma metastasis and explore whether its underlying mechanism involves ferroptosis induction in cancer cells. Methods: The CCK8 assay and wound healing assay and transwell were conducted to determine the cell viability and migration ability of A549 and H1299 cells, respectively. EMT process was assessed by western blot and RT-PCR to detect protein and mRNA levels of EMT markers. ROS and cell iron were measured to determine ferroptosis level. Results: Eriocitrin treatment significantly inhibited cell viability and migration ability in a concentration-dependent manner. Furthermore, eriocitrin administration for 24 hours resulted in enhanced expression of E-cadherin, while downregulating vimentin, N-cadherin and snail expression, indicating marked repression of the EMT process. Additionally, eriocitrin significantly induced ferroptosis in A549 and H1299 cells, as evidenced by increased ROS levels, downregulation of Nrf-2, SLC7A11 and GPX4 expression, and enhanced cellular iron accumulation. Moreover, pretreatment with the ferroptosis inhibitor ferrostatin-1 effectively abrogated the inhibitory effects of eriocitrin on EMT. Conclusions: Our findings further support the anti-cancer properties of eriocitrin, as evidenced by its ability to inhibit the EMT process in LUAD cells, which is partially mediated through induction of ferroptosis in cancer cells.
Complex Electrical Resistivity for Monitoring DNAPL Contamination

Nearly all Department of Energy (DOE) facilities have landfills and buried waste areas. Of the various contaminants present at these sites, dense non-aqueous phase liquids (DNAPL) are particularly hard to locate and remove. There is an increasing need for external or non-invasive sensing techniques to locate DNAPLs in the subsurface and to track their spread and monitor their breakdown or removal by natural or engineered means. G. Olhoeft and colleagues have published several reports based on laboratory studies indicating that strong electrical signatures are produced when organic solvents, notably toluene, PCE, and TCE, reside in clay-bearing soils. According to Olhoeft, these electrical signatures are apparently characteristic of and unique to the particular organic solvent involved. The experiments are performed by packing the contaminated soil in a sample holder and a 4-electrode complex electrical resistivity measurement is made, where two of the electrodes are used to impose a sinusoidal electric current and the remaining two electrodes are used to sense the response voltage of the specimen. The relative phase (or time delay) between the source and the response signals at low excitation frequencies is a particularly sensitive measure of electrochemical processes occurring within the specimen. This suggests the basis of anmore » ideal new measurement technique for geophysical characterization of NAPL pollution. Despite the promising laboratory results, attempts to measure these effects in the field for characterizing polluted sites, including studies supported by DOE funding, seldom have been successful. Encouraged by the aforementioned laboratory results we had proposed to bring the field measurement of complex resistivity as a means of pollution characterization from the conceptual stage to practice. For this purpose we intend to document the detectability of clay-organic interactions with geophysical measurements in the laboratory, develop further understanding of the underlying physical and chemical mechanisms, and then apply these observations to develop field techniques to monitor the remediation of organic pollutants. Research Progress« less
Thermal diffusivity of Mg2SiO4, Fe2SiO4, and NaCl at high pressures and temperatures

The pressure and temperature variations of thermal diffusivity of poly crystalline Mg2SiO4 have been measured for the range 24 to 50 kb and 400° to 1300°K. Effect of the olivine-spinel phase transition on thermal diffusivity of Fe2SiO4 was studied at 48.5 kb for the temperature range 350° to 650°K. Synthetic samples with grain size 1 to 5 microns were used. For the pressure range studied, the reciprocal of thermal diffusivity 1/κ of Mg2SiO4 increases almost linearly with temperature up to about 1200°K, as expected from the theory of phonon conduction, but is nearly constant above that temperature. The 1/κ versus temperature curve of Fe2SiO4 (olivine) is nearly straight up to 700°K, where it becomes slightly convex. The thermal diffusivity of NaCl is measured under similar conditions for comparison with Bridgman's data. The agreement is reasonably good. The pressure derivative ∂κ/∂P, at P = 40 kb is 1.8 × 10−4 cm2/sec kb (at 700°K) and 0.8 × 10−4 cm2/sec kb (at 1100°K) for Mg2SiO4, and 4.7 × 10−4 cm2/sec kb (at 700°K) for NaCl. This pressure dependence can be explained by the theory of phonon conduction. The thermal diffusivity of Fe2SiO4 (spinel) is about 1.5 times that of Fe2SiO4 (olivine) over the range 350° to 650°K. The effect of radiative heat transfer in Mg2SiO4 is discussed. The photon mean free path is estimated to be 0.3 mm at 1400°K.
A vertical girdle fabric in the NorthGRIP deep ice core, North Greenland

Abstract A high-resolution study of c-axis fabrics has been performed on the NorthGRIP deep ice core from North Greenland. A newly developed automatic ice-fabric analyzer has been used to measure c-axis orientations on vertical thin sections at 142 different depths between 100 and 2920 m in the core. Detailed comparison studies show that this new method produces results that are in full accordance with those obtained from conventional manual measurements. Fabric development in ice of the NorthGRIP core can be explained by rotation of c axes, controlled by the prevailing stress systems. In the upper 800 mthe c axes appear to distribute uniformly, but in the depth interval 900–2500m they tend to cluster around a vertical plane. This vertical girdle pattern is strengthened with depth, forming the first clear evidence of this fabric type in a Greenland deep ice core. Such fabric development has previously been observed in the Vostok ice core from East Antarctica, where converging flow is believed to occur. the most likely interpretation of the NorthGRIP girdle fabric is that the c axes are rotating away from a horizontal-tension axis across the main ice divide, which runs north-northwest–south-southeast through the NorthGRIP drilling site. This is supported by information available from surface velocity measurements. Within the girdle fabric, increased concentration of c axes parallel to the core axis is observed with increasing depth, indicating combined effects of vertical compression and horizontal tension on the fabric development. from about 2500 m depth, the girdle-type fabric starts to give way to a strong vertical single-maximum fabric, which persists to 2920m depth, where drilling was terminated 150 mabovebedrock in the year 2000. the single maximum seems to suggest that bed-parallel simple shear is exerting a strong influence on the fabric in the lowest part of the ice sheet down to 2920 m.