Miracle-dz/UniFAR-FTUs huggingface dataset:
Glia Maturation Factor Beta as a Novel Biomarker and Therapeutic Target for Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most common types of cancer. The novel sensitive biomarkers and therapeutic targets are urgently needed for the early diagnosis of HCC and improvement of clinical outcomes. Glia maturation factor-β (GMFB) is a growth and differentiation factor for both glia and neurons and has been found to be tightly involved in inflammation and neurodegeneration conditions. In our study, the expression level of GMFB was significantly up-regulated in patients with HCC and positively co-expression with tumor node metastases (TNM) stage and histopathological grade of HCC. The high expression level of GMFB was remarkably associated with poor overall survival, which mainly occurred in males rather than females. Multivariate analysis revealed GMFB to be an independent prognostic factor for overall survival in patients with HCC. Results of Gene Ontology (GO) and KEGG pathways analysis showed that down-regulation of pathways related to protein translation and mitochondria function were enriched. Protein-protein interaction analysis revealed the central role of mitochondria protein in HCC. The downregulation of genes involved in glycolysis and gluconeogenesis was observed among the co-expression genes of GMFB. Knockdown of GMFB in Hep3B significantly inhibited proliferation, migration, and invasion of Hep3B cells, and also downregulated the expression levels of some of metal matrix proteinase (MMP), increased mtDNA copy number and loss of mitochondrial transmembrane potential. GMFB influences the malignancy rate of HCC possibly through regulation of the expression of MMPs, mtDNA function and glycolysis. We proposed that GMFB was a promising HCC diagnostic and prognostic biomarker and therapeutic target in HCC.
Combing Instrumental Variable and Variance Matching for Aircraft Flutter Model Parameters Identification

When the observed input-output data are corrupted by the observed noises in the aircraft flutter stochastic model, we need to obtain the more exact aircraft flutter model parameters to predict the flutter boundary accuracy and assure flight safety. So, here we combine the instrumental variable method in system identification theory and variance matching in modern spectrum theory to propose a new identification strategy: instrumental variable variance method. In the aircraft flutter stochastic model, after introducing instrumental variable to develop a covariance function, a new criterion function, composed by a difference between the theory value and actual estimation value of the covariance function, is established. Now, the new criterion function based on the covariance function can be used to identify the unknown parameter vector in the transfer function form. Finally, we apply this new instrumental variable variance method to identify the transfer function in one electrical current loop of flight simulator and aircraft flutter model parameters. Several simulation experiments have been performed to demonstrate the effectiveness of the algorithm proposed in this paper.
Effect of Different Nitrogen Doses on Agricultural and Quality Characteristics of Mentha x piperita L. and Mentha spicata L. Species

The effect of various amounts of nitrogen (N) fertilizer (0, 50, 100, 150 and 200 kg ha) on the growth and quality characteristics of Mentha x piperita and Mentha spicata species was studied under Turkey’s Uşak ecological conditions in 2017-2019. In the study, harvests in the vegetation period of 2018 and 2019 were combined and the average plant height and essential oil content, total fresh and dry herbage, dry leaf and essential oil yields, and the composition of the essential oil was examined. The plant height, total yields and essential oil content of both mint species increased significantly with N fertilizer applications. The highest total yields and essential oil contents in both mint species were obtained from 200 kg N ha. The main components of the essential oil were identified as menthol and menthon in Mentha x piperita and carvone and limonene in Mentha spicata. The highest menthol content (44.66%) was obtained from 100 kg N ha, while the highest carvone content (59.90%) was obtained from 200 kg N ha. The total yields of Mentha x piperita increased significantly with increase in N fertilization up to 200 kg ha, while the total yields of Mentha spicata increased with increase in N fertilization up to 150 kg ha.
Design of an Array-based Plane Wave Generator for Compact Field Antenna Testing

─ A near-field planar array of wideband dual polarized antennas for plane-wave synthesis has been investigated. The paper presents a PWG with a concentric ring array of 84 Vivaldi antennas which can work at 0.6GHz-3GHz. The constraint least square (CLS) algorithm is used to optimize the weight coefficients of the array elements, which effectively reduce the influence of system uncertainty on quiet zone (QZ) ripple. To reduce the system cost and complexity, the array elements in each concentric ring form a sub-array and the elements of the same sub-array adopt a passive beam forming network. The simulation and initial test results of a circular QZ with a diameter of 600 mm are given. The results demonstrate the feasibility of our design. Index Terms ─ Constrained Least Square (CLS), plane wave synthesis, wideband dual polarized.
THE EFFECT OF EFFICACY OF SOME PLANT POWDERS, BIOLOGICAL TREATMENTS AND SOME NANOSCALE APPLICATIONS IN THE CONTROL OF ORYZAEPHILUS SERRINAMENSIS BEETLE

This laboratory study was conducted to demonstrate the effect of the biocide effect of Trichoderma harzianum, silver nanoparticles in the third larval age and the Oryzaephilus full-size beetle, and five concentrations of the biocide T. harzianum (250, 500, 1000, 2000, 4000) ppm and five Concentrations of silver nanoparticles are (1000, 2000, 3000, 5000, 10000, and 20000) ppm. The results showed that the fungicide T. harzianum had the most recent killing rates for all concentrations, as the highest killing rate for the third larval age was 96.7% at 4000 ppm during 72 hours of treatment, while the lowest killing rate for the third larval age was 16.7% at the concentration 250 ppm during 24 hours of treatment. As for the camels, the highest killing rate with the fungicide was 86.7% at the concentration of 4000 ppm during 168 hours of treatment, while the lowest killing percentage for the adult beetle was 0% at the concentration of 250 ppm within 24 hours of the treatment, as for the effect of particles Silver nanoparticles were the highest killing percentage for the third larval age 100.0% at the concentration of 5000 ppm within 72 hours of the treatment, while the lowest killing percentage for the third larval age was 13.3% at the concentration of 1000 ppm within 24 hours of the treatment. As for the adult beetle have reached the highest rate of killing 88.7% when concentrating 20000 ppm within 72 hours of treatment and concentrating 500 and 1000 ppm during 144 hours of treatment. The lowest killing rate of the adult beetle was 16.7% when concentrating 5000 ppm during 24 hours of treatment.
Study of the functional status of cardiovascular autonomic neuropathy in type 1 diabetic mellitus as compared to healthy individuals

Background: In the presence of type 1 diabetes mellitus, the incidence of autonomic dysfunction has increased and various evaluation methods have been identified. Each of these is the classical autonomic control tests. Aims and Objectives: The present study was conducted to evaluate and compare autonomic function tests in cases of type I diabetes mellitus and healthy individuals. Material and Methods: In the study, 60 cases of diagnosed type I diabetes mellitus and 60 age and sex-matched healthy individuals both between the age group of 18-25 years were included. Autonomic function tests were carried out and these parameters were compared between these two groups using an unpaired t-test. Results: Deep breathing difference in patients of type I diabetes mellitus was significantly decreased as compared to healthy individuals. Valsalva ratio in patients of type I diabetes was significantly decreased as compared to healthy individuals. Postural tachycardia index in patients of type I diabetes was significantly decreased as compared to healthy individuals. The decrease in systolic blood pressure in patients with type I diabetes was substantially higher than in healthy individuals. The increase in diastolic blood pressure with isometric handgrip monitoring in patients with type I diabetes was substantially lower relative to healthy individuals. Conclusion: Deep breathing difference, Valsalva ratio, postural tachycardia index are a measure of parasympathetic function. Deranged autonomic function tests in type I diabetic patients may be due to sympathetic and parasympathetic dysfunction.
ANALGESIC EFFECT OF QUERCETIN 3,7-O-DIMETHYL ETHER ISOLATED FROM SALVIA OFFICINALIS

To evaluate the analgesic effect of flavonoid quercetin 3,7-O-dimethyl ether isolated from ethyl acetate fraction of the methanol extract of Salvia officinalis. The dried leaves of Salvia officinalis were subjected to extraction with methanol, and then it was fractioned by water and ethyl acetate solvent. The antinociceptive activity of flavonoid quercetin 3,7-Odimethyl ether isolated from ethyl acetate fraction was assessed using heat-induced (hot-plate) and chemical-induced (acetic acid and formalin) nociception models in mice and rats. Involvement of opioid system and cyclic guanosine monophosphate (cGMP) pathway were also investigated using naloxone and 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), respectively. Pretreatment with quercetin 3,7-O-dimethyl ether significantly (p < 0.05) and dose-dependently increased the hot plate latency time. It also reduced the number of abdominal constrictions and paw lickings (in both early and late phases) induced by acetic acid and formalin, respectively. Naloxone and ODQ significantly attenuated the antinociceptive activity of quercetin 3,7-O-dimethyl ether in the hot plate and both phases of formalin test. Antinociceptive action of flavonoid quercetin 3,7-O-dimethyl ether support the traditional use of Salvia officinalis in folk medicine. This study provide evidence that the antinociceptive effect of quercetin 3,7O-dimethyl ether is partly mediated by opioid system and cGMP pathway. Finally, the quercetin 3,7-Odimethyl ether isolated from this plant appears to contribute for the antinociceptive property of different extracts from Salvia officinalis.
Occupational Stress among Indian Doctors during COVID-19

Background: There is growing evidence that psychiatric illnesses due to workplace stress (Wong, 2008) are more common in medical professionals worldwide (stress, depression, anxiety and insomnia) and feelings of emotional exhaustion, and it was found to be related to shortfalls in regime of health and wellness. Emerging content in support of the truth that Indian health care professionals (Dasgupta, 2009) are now operating under pressure due to the workplace condition, and the current COVID-19 pandemic has also amplified (Elbay, 2020), and we need to research the occupational stress among Indian doctors more than any other time, that can carry out observations from the data gathered during this review, which will be crucial in identifying the problem at hand and providing appropriate data-backed recommendations for changing the status quo. Aim: To analyse various aspects of Occupational Stress among Indian doctors during COVID19 which might lead to a lack in the efficacy of execution in patient treatment. Materials and Methods: In order to capture and evaluate psychological responses from Indian Medical Professionals and related characteristics during the COVID-19 pandemic, an online study with the help of survey has been conducted. It comprises of three sub divisions addressing topics pertaining to the following key areas. : (1) sociodemographic data (2) Stress at the workplace during COVID-19(3) information on individuals` working condition. Results: Factors found to be related to higher workplace stress in line staff healthcare professionals were as specified: Increased average operating hours, increased number of patients treated for Covid-19, reduced level of peer and supervisor assistance, lower logistic aid, and lower sentiments of performance during activities related to Covid-19. Moderate or mild level of stress was encountered by approximately two-thirds of the sample. Depression, anxiety or fatigue is linked to reduced extravagance in fun gatherings, verbal or physical violence in patient/caregiver hands, perceptions that colleagues do not display concern for patients and also towards their peers. Conclusions: The latest study indicates a marginally greater proportion of Indian doctors who encounter stress, fatigue and burnout experiences. Long working hours and negative patient related effects (attributed to lack of per patient time, overloaded with critical stressful cases), the predominance of tension, anxiety depression, and emotional exhaustion is associated with detrimental doctor patient experiences and uncomfortable group dynamics among colleagues. Our studies have found the possible reasons that create workplace stress that need to be taken into account when battling a catastrophe that has a significant effect on civilization globally, to protect the emotional health of physicians
Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) Expression and its Correlation with Progression of Oral Squamous Cell Carcinoma

1. *Dr. Mridul Kumar Saha, Assist Professor, Department of Pathology, Colonel Malek Medical College, Manikganj. mridulkumarsaha@yahoo.com 2. Dr. Md. Oyes Quruni, Assistant Professor, Department of Pathology, Sheikh Hasina Medical College, Tangail. 3. Dr. Syeda Sadia Afrin, Lecturer, Department of Pathology, Dhaka Medical College. 4. Dr. Md. Shahadat Hossain, Lecturer, Lecturer, Department of Pathology, Dhaka Medical College. 5. Dr. Farhad Mahmud, Associate Professor, Department of Pathology, Colonel Malek Medical College, Manikganj. 6. Dr. SM A Mahmud, Lecturer, Department of Pathology, Dhaka Medical College. 7. Dr. Mohammad Shahed Ali Jinnah, Associate Professor, Dhaka Medical College. 8. Professor Dr. Md. Rezaul Karim Dewan, Head of the Department, Department of Pathology, Dhaka Medical College.
Postharvest Quality of Two Mangosteen (Garcinia mangostana L.) Fruit Maturities Held in Ambient and CoolBot-equipped Cold Storage

Mangosteen fruit has a good demand in the global market, however, local production is beset with high postharvest losses. The effectiveness of low temperature in maintaining fruit postharvest quality is well known but costly. In this study, the effects of ambient storageand CoolBot-equipped room are determined on two maturity stages of mangosteen. The mangosteen fruit which is classified as reddish purple or dark purple was stored in either ambient conditions (26.7±0.6°C, 88.4±3.4% RH) or inside a modified cold room using CoolBot (9.9±1.8°C, 77.8±10.7% RH) and the quality was evaluated weekly. Mangosteen at both maturity stages had at least 8.5 days of shelf life under ambient conditions and 29.8 days under CoolBot storage. Peel color was maintained for less than four days after storage in ambientm while 35 days in room with CoolBot. There was a higher total soluble solids (TSS) content in dark purple fruit in both storage conditions. Pericarp hardening of the fruit was observed starting at 7 and 28 days in ambient and CoolBot storage, respectively. Fruit stored in the CoolBot-equipped room had better visual and calyx quality, lower weight loss, higher TSS, and delayed peel color change. Chilling injury which manifested as inner pericarp browning at 35 days did not vary between the two fruit maturities in cold storage. Storage of reddish purple mangosteen fruit using CoolBot maintained the fruit quality until 28 days.
Stres Dan Upaya Yang Dilakukan Mahasiswa Dalam Menjalani Pembelajaran Selama Pandemi Covid-19

Received 2 February 2021 Accepted 4 May 2021 Published 25 June 2021 Students who experience stress during online learning are quite high. Stress will have an impact on student life in the future. For this reason, it is necessary to explore the stress experienced by students. The purpose of this study was to explore the stress and efforts made by health students in undergoing online learning. This research is qualitative with a phenomenological approach. The number of samples was 6 health students. Sampling was by purposive sampling. Data were analyzed using the Collaizi technique. The results showed that there were four themes of stress experienced by students, namely: perceptions of stress, feelings during stress, signs of stress symptoms, and causes of stress. The efforts made have two themes, namely: internal and external efforts. Students experience stress during online learning and make efforts to deal with the stress they experience. The results of this study provide important information for better learning management to anticipate student stress during the pandemic period. Keyword:
INVESTIGATION OF ALKALINE PHOSPHATASE EXPRESSION IN THE SMALL INTESTINES OF THE BRONZE TURKEY (MELEAGRIS GALLOPAVO)

The aim of our investigation was to study the expression of the enzyme Alkaline phosphatase in the small intestines of the bronze turkey in the age aspect. Forty clinically healthy bronze turkeys (twenty males and twenty females) were studied. The groups of the birds were at age 1, 7, 14, 28, 35, 49, 56, 90, 120, and 240 days. Each group consisted of five males and five female birds. The enzyme’s expression was investigated by Gomori staining. The most significant expression of tissue alkaline phosphatase was observed in the epithelial cells of the duodenum. It was weaker in the jejunum and weakest in the ileum. In the three intestinal segments, high enzyme activity was observed during the first weeks of hatching (from the 1st to the 14th day in the duodenum and ileum, and from the 1st to the 28th day in the jejunum).
Synthesis of high-area chemically modified electrodes using microwave heating

Abstract The synthesis of dimensionally stable carbon-based chemically modified electrodes (CMEs) is a challenge. The synthesis method, the electrode composition, and the heating used influences various properties of the electrodes. Here, we show an innovative, low cost, and efficient heating method for the CMEs production. We deposited ternary ruthenium, antimony, and tantalum or bismuth oxides on carbon-felts by the Pechini method focusing on the influence of different heating methods (conventional and microwave) on their electrochemical and physical properties. The oxides synthesized using microwave heating coated completely the carbon-felts fibers, displaying homogeneous morphology, while maintaining their three-dimensional character. XRD and XRF analyses confirm the presence of the desired oxides on the coating surfaces and the experimental metal load values close to the nominal (87–91% for Ru, 3–6% for Sb, and 4–7% for Ta or Bi, respectively). The microwave-assisted method yields CMEs with electrochemical active areas 136-fold (for tantalum-based) and 153-fold (for bismuth-based) higher than the unmodified carbon felt. The service lifetime of the CMEs is almost twice as high when using microwave heating than when using conventional heating, which is attributed to the complete and homogeneous coating of the fibers obtained using this heating method. In contrast, the conventional heating led to the incomplete covering of the fibers and to CMEs with low stability. Therefore, the use of microwave heating for the CMEs synthesis reduces the production time at around 60%, thus decreasing the production costs and producing CMEs with improved quality and stability when compared to both conventional-made CMEs and unmodified electrodes.
CBMS Conference: Gaussian Random Fields, Fractals, SPDEs, and Extremes

Random fields are stochastic processes indexed by vectors in multidimensional Euclidean space RN or its subsets such as the N -dimensional integer lattice ZN , the unit sphere SN−1 or more general manifolds. The study of random fields was originated from the work of Kolmogorov (1941) in statistical theory of turbulence and Lévy’s work on multiparameter Brownian motion [cf. Lévy (1948, 1963)]. In Mathematics, random fields form an important class of stochastic processes. They play significant roles in studying stochastic partial differential equations (their solutions, when exist, are random fields). The studies of random fields and stochastic partial differential equations have recently entered a period of rapid growth. The enormous amount of current, as well as past, interest in random fields has been motivated in part by the vast number of their applications to sciences outside mathematics ranging from astronomy to fluid mechanics, and to finance. These connections have, in turn, motivated and generated a large number of exciting and novel mathematical questions. The list of references further information. The lectures will put the latest developments on random fields from the subjects of probability theory, stochastic partial differential equations, fractal geometry, and extreme value theory in a nutshell and present to young researchers and graduate students in Probability and related areas. We will identify open problems in the theory of random fields that are motivated by statistics, mathematical physics, among other disciplines. The following are the main topics that will be covered by the lectures.
Predicting Spanish Emigration and Immigration

What is the future of international migration flows? The growing availability of bilateral international migration data has resulted in an improved understanding of the determinants of migration flows through the estimation of theory-based gravity models. However, the use of these models as a prediction tool has remained a mostly unexplored research area. This paper estimates simple gravity models of bilateral migration flows for the whole world and projects these models into the future. We focus on a particularly hard-to-predict country, Spain, which evolved from an emigrant-sending to an immigrant-receiving country, and compare the estimates from internationally available data to those coming from local sources. Our results show that the projections of migration flows depend more heavily on the span of the baseline dataset used to estimate the model than on the particular functional form and variables chosen for the prediction although we confirm the relevance of origin-country demographic factors.
Transcriptional and anatomical diversity of medium spiny neurons in the primate striatum

Medium spiny neurons (MSNs) constitute the vast majority of striatal neurons and the principal interface between dopamine reward signals and functionally diverse cortico-basal ganglia circuits. Information processing in these circuits is dependent on distinct MSN types: cell types that are traditionally defined according to their projection targets or dopamine receptor expression. Single-cell transcriptional studies have revealed greater MSN heterogeneity than predicted by traditional circuit models, but the transcriptional landscape in the primate striatum remains unknown. Here, we set out to establish molecular definitions for MSN subtypes in Rhesus monkeys and to explore the relationships between transcriptionally defined subtypes and anatomical subdivisions of the striatum. Our results suggest at least nine MSN subtypes, including dorsal striatum subtypes associated with striosome and matrix compartments, ventral striatum subtypes associated with the nucleus accumbens shell and olfactory tubercle, and an MSN-like cell type restricted to μ-opioid receptor rich islands in the ventral striatum. Although each subtype was demarcated by discontinuities in gene expression, continuous variation within subtypes defined gradients corresponding to anatomical locations and, potentially, functional specializations. These results lay the foundation for achieving cell-type-specific transgenesis in the primate striatum and provide a blueprint for investigating circuit-specific information processing.