Miracle-dz/UniFAR-FTUs huggingface dataset:
Using GIMMS NDVI time series to estimate the impacts of grassland vegetation cover on surface air temperatures in the temperate grassland region of China

Abstract Exploring the impacts of vegetation cover on regional climate is very important to assess the relationship between vegetation and climate, and to predict regional climate change in vegetated areas. Using the time series of Global Inventory Modelling and Mapping Studies (GIMMS) normalized difference vegetation index (NDVI), we estimated the impacts of grassland vegetation cover on surface air temperatures based on the observation minus reanalysis (OMR) approach. The theory of the OMR approach is that reanalysis data are not sensitive to local land surface properties, thus the changes in OMR can be attributed to land effects. The method used in this letter is that rates of change in OMR are regressed (using stepwise regression) on average NDVI and the rate of NDVI change. We applied this multiple stepwise regression analysis in the temperate grassland region of China during the growing season from 1982 to 2005. To evaluate the accuracy of regress equations, we estimated the monthly OMR temperatures during 1983–2005 and then compared the monthly estimated and actual OMR temperatures. The results showed that the estimated OMR temperatures were well consistent with actual OMR temperatures in all the months, with the correlation coefficients between them ranging from 0.83 to 0.98. It indicates that combined with the OMR approach, GIMMS NDVI can be used to accurately estimate the impacts of grassland vegetation on surface air temperatures in temperate grassland areas of China.
Effects of Trainer Continuity and Experience on Neurofeedback Treatment of ADHD in Children

Objective: To examine whether trainer continuity and experience impacted the significantly improved inattention scores (pre-post d = 1.44–1.53) seen in both the control and active treatment groups of “Double-Blind Placebo-Controlled Randomized Clinical Trial of Neurofeedback for Attention-Deficit/Hyperactivity Disorder” (2021). Methods: The primary trainer was the one who coached the most treatment sessions with a participant. A trainer was considered experienced after coaching 100 sessions. The percentage of sessions each participant had with their primary trainer and percentage with an experienced trainer were entered as independent variables into linear mixed models in SASv.9. 4 with improvement in inattention ratings by parents and teachers (primary outcome) as dependent variable. Results: Effect of trainer continuity on primary outcome was not significant (B = −0.016, SE = 0.153, t(123) = −0.11, p = . 916). However, percent of sessions with an experienced trainer correlated with increased improvement (B = 0.238, SE = 0.095, t(123) = 2.51, p = . 013). Conclusion: Neurofeedback trainer continuity does not appear important, while trainer experience with at least 100 sessions correlates with better outcomes.
Child Maltreatment as a Risk Factor for Rejection Sensitivity: A Three-Level Meta-Analytic Review

Theoretical and empirical evidence has suggested that child maltreatment victimization is associated with rejection sensitivity. However, empirical evidence on this association is inconsistent. Therefore, this meta-analysis aimed to examine the overall association between child maltreatment and rejection sensitivity, and to investigate variables that may affect the strength of this association. Studies eligible for inclusion were searched in the databases: Web of Science, Science Direct, PubMed, MEDLINE, and China National Knowledge Infrastructure after which relevant studies were coded. Studies were synthesized in advanced three-level meta-analytic models in R. A total of 16 studies (N = 5,335 participants) yielding 41 effect sizes were included. Results showed that child maltreatment is significantly and positively related to rejection sensitivity (mean r = 0.230; p < .001), and to a small extent. Furthermore, this association is stronger for emotional abuse (r = 0.275) than for physical abuse (r = 0.157). It is not affected by the mean age and gender distribution of primary study samples nor by sample type (community sample versus clinical sample). It is concluded that child maltreatment is a risk factor for developing rejection sensitivity later in life. Therefore, interventions for rejection sensitivity should consider potential trauma resulting from prior child maltreatment experiences.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants

Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake inhibitors (SSRIs; i.e., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), serotonin and norepinephrine reuptake inhibitors (i.e., desvenlafaxine, duloxetine, levomilnacipran, milnacipran, and venlafaxine), and serotonin modulators with SSRI‐like properties (i.e., vilazodone and vortioxetine) are primary pharmacologic treatments for major depressive and anxiety disorders. Genetic variation in CYP2D6, CYP2C19, and CYP2B6 influences the metabolism of many of these antidepressants, which may potentially affect dosing, efficacy, and tolerability. In addition, the pharmacodynamic genes SLC6A4 (serotonin transporter) and HTR2A (serotonin‐2A receptor) have been examined in relation to efficacy and side effect profiles of these drugs. This guideline updates and expands the 2015 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and SSRI dosing and summarizes the impact of CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes on antidepressant dosing, efficacy, and tolerability. We provide recommendations for using CYP2D6, CYP2C19, and CYP2B6 genotype results to help inform prescribing these antidepressants and describe the existing data for SLC6A4 and HTR2A, which do not support their clinical use in antidepressant prescribing.
Comparison of Established and Novel Insecticides on Survival and Reproduction of Folsomia candida

Neonicotinoids have been among the most widely and abundantly used insecticides for most of the current century. The effects of these substances on nontarget terrestrial and aquatic organisms have resulted in a significant decrease in their use in many parts of the world. In response, the application of several novel classes of insecticides including diamides, ketoenols, pyridines, and butenolides has significantly increased. The hexapod subclass Collembola is an ecologically significant and widely distributed group of soil invertebrates often found in leaf litter and in surficial soils. We exposed the parthenogenic collembolan species Folsomia candida to six insecticides in a sandy loam soil for 28 days, including two neonicotinoids (thiamethoxam and clothianidin), a diamide (cyantraniliprole), a ketoenol (spirotetramat), a pyridine (flonicamid), and a butanolide (flupyradifurone) to assess the effect of each insecticide on survival and reproduction. Clothianidin, thiamethoxam, and cyantraniliprole (median effective concentration [EC50] values for reproduction: 0.19, 0.38, and 0.49 mg/kg soil, respectively) had a greater effect on survival and reproduction of F. candida than flupyradifurone, spirotetramat, and flonicamid (EC50 values for reproduction: 0.73, >3.08, and 5.20 mg/kg soil, respectively). All significant impacts found in our study were observed at concentrations below concentrations of the active ingredients that would be expected in agricultural soils. Environ Toxicol Chem 2023;42:1516–1528. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Physical Dating Violence Victimization among LGBTQ Youth: Disclosure and Association with Mental Health

Youth dating violence and youth suicide are both major public health concerns. However, little research examines the intersection of these issues among lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ) youth. The current study examined the association between physical dating violence victimization and mental health using online survey data collected from 39,126 LGBTQ youth of ages 13 to 24 in the United States. Overall, 11% of LGBTQ youth who were in a relationship in the past year experienced physical dating violence victimization, with 4% having experienced it once and 7% having experienced it multiple times. Rates of experiencing physical dating violence victimization varied based on a number of youth characteristics and environmental factors. Past-year physical dating violence victimization was associated with nearly four times the odds of attempting suicide in the past year. Given the intersection of suicide risk and dating violence among LGBTQ youth, dating violence prevention organizations must be LGBTQ-inclusive, and suicide prevention must be equipped to address dating violence victimization. The higher rates of physical dating violence victimization among multiple marginalized and socioeconomically disadvantaged LGBTQ youth suggest the need for an intersectional approach that addresses the structural factors that place LGBTQ youth at risk for physical dating violence.
Ventilatory response to peripheral chemoreflex and muscle metaboreflex during static handgrip in healthy humans: evidence of hyperadditive integration

What is the central question of this study? What is the effect of peripheral chemoreflex and muscle metaboreflex integration on ventilation regulation, and what is the effect of integration on breathing‐related sensations and emotions? What is the main finding and its importance? Peripheral chemoreflex and muscle metaboreflex coactivation during isocapnic static handgrip exercise appeared to elicit a hyperadditive effect with regard to ventilation and an additive effect with regard to breathing‐related sensations and emotions. These findings reveal the nature of the integration between two neural mechanisms that operate during small‐muscle static exercise performed under hypoxia.
suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury

Acute kidney injury (AKI) secondary to sepsis results in poor outcomes and conventional kidney function indicators lack diagnostic value. Soluble urokinase plasminogen activator receptor (suPAR) is an innate immune–derived molecule implicated in inflammatory organ damage. We characterized the diagnostic ability of longitudinal serum suPAR levels to discriminate severity and course of sepsis-induced AKI (SI-AKI) in 200 critically ill patients meeting Sepsis-3 criteria. The pathophysiologic relevance of varying suPAR levels in SI-AKI was explored in a polymicrobial sepsis model in WT, (s)uPAR-knockout, and transgenic suPAR-overexpressing mice. At all time points studied, suPAR provided a robust classification of SI-AKI disease severity, with improved prediction of renal replacement therapy (RRT) and mortality compared with established kidney biomarkers. Patients with suPAR levels of greater than 12.7 ng/mL were at highest risk for RRT or death, with an adjusted odds ratio of 7.48 (95% CI, 3.00–18.63). suPAR deficiency protected mice against SI-AKI. suPAR-overexpressing mice exhibited greater kidney damage and poorer survival through inflamed kidneys, accompanied by local upregulation of potent chemoattractants and pronounced kidney T cell infiltration. Hence, suPAR allows for an innate immune–derived and kidney function–independent staging of SI-AKI and offers improved longitudinal risk stratification. suPAR promotes T cell–based kidney inflammation, while suPAR deficiency improves SI-AKI.
Math anxiety and the shifting function: An event‐related potential study of arithmetic task switching

Why is math anxiety usually related to less efficient math processing? According to attentional control theory, anxiety leads to reduced attentional control, which often entails a greater investment of resources (e.g., more time or effort) to carry out a cognitive task. The executive functions mainly affected by anxiety are inhibition and shifting. Previous studies suggest that math anxiety may impair the inhibitory function. In the present study, the relationship between math anxiety and shifting efficiency when switching between two‐digit additions and subtractions was examined. Twenty highly math‐anxious and 20 low math‐anxious individuals participated in an event‐related potential (ERP) transition‐cueing experiment. Math anxiety was expected to delay the shifting process, leading to a larger switch cost in response time and no centroparietal cue‐locked switch‐specific positivity registered in the electroencephalogram during the cue‐target interval. Highly math‐anxious individuals showed a larger switch cost than their low math‐anxious peers. Asymmetrical switch effects between operations in response time were found in both groups, which might be due to larger sequential difficulty effects after subtractions than after additions. The cue‐locked switch‐specific positivity was present only in the low math‐anxious group. The present results suggest that highly math‐anxious individuals take longer to shift task sets. Additionally, the highly math‐anxious group showed a more positive frontal P2 after the cue that announced a switch to subtraction, probably indicating stronger attentional capture by this cue, because the most threatening condition is anticipated. Taken together, these data suggest that math anxiety also impairs attentional control when switching between arithmetic tasks.
The Double Dixie Cup Problem

The familiar childhood occupation of obtaining a complete set of pictures of baseball players, movie stars, etc., which appear on the covers of dixie cups raises some interesting questions. One, which has already been answered, is the "single dixie cup problem," that of determining the expected number, E(n), of dixie cups which must be purchased before a complete set of n pictures is obtained: E(n) = n(I + 1/2 + * * * + 1 /n) ( [1 ] p. 213). Some time ago W. Weissblum asked how long, on the average, it would take to obtain two complete sets of n pictures. This corresponds to the situation observed when two tots collect cooperatively, i.e., "trading" takes place. This "double dixie cup" problem cannot be handled by the same device used for the problem of the single set and in this paper we find a new method which allows us to write down the solution, Em(ln), (as an easily evaluated definite integral) for the problem of collecting m sets. For m fixed and n large the expected number of dixie cups turns out to be n(log n+(m1) loglog n+o(l)). Thus, although the first set "costs" n log n, all further sets cost n loglog n. Suppose m sets are desired. Let pi be the probability of failure of obtaining m sets up to and including the purchase of the ith dixie cup. Then the expected number of dixie cups Em(ln) = Z%=0 pi, by a well-known argument ([1] p. 211). Now pi= Ni/ni where Ni is the number of ways that the purchase of i dixie cups can fail to yield m copies of each of the n pictures in the set. If we represent the pictures by xi, * , xn, then Ni is simply (xi + * * * +xn)i expanded and evaluated at (1, . . ., 1) after all the terms have been removed which have each exponent for each variable larger than m -1. Now consider m fixed and introduce the following notation. If P(x1, . . . , x,,) is a polynomial or power series we define { P(xi, . . . , x,C) } to be the polynomial, or series, resulting when all terms having all exponents _ m have been removed. In terms of this notation pi is { (xi + * +x.) } /ni evaluated at x = *= -1. If we now make the definition
Analysis of particle therapy registries based on a unified treatment policy for esophageal cancer

Abstract This study aimed to evaluate the efficacy and safety of particle therapy (proton beam therapy and carbon-ion radiotherapy) for esophageal cancer by analyzing prospective nationwide registry data from particle therapy facilities throughout Japan. Patients diagnosed with esophageal cancer who received particle therapy between May 2016 and June 2018 were recruited from the registries of 12 particle therapy centers in Japan. Eventually, we enrolled 174 patients who met the inclusion criteria. Of the 174 patients, 137 (78.7%) were male, with a median age of 69 years (range: 41–88 years). Clinical stages included I (n = 55; 31.6%), II (n = 31; 17.8%), III (n = 82; 47.1%), IV (n = 3; 1.7%) and unknown (n = 3; 1.7%) (Union for International Cancer Control, seventh edition), and the median follow-up period was 908 days (range: 76–1669 days) for all patients. The 3-year overall survival (OS) rate, the 3-year progression-free survival (PFS) rate and the 3-year local control (LC) rates were 60.5, 53.2 and 72.7%, respectively. For each clinical stage, the 3-year OS rates were I, 84.8%; II, 60.3% and III, 42.9%; the 3-year PFS rates were I, 71.9%; II, 58.3% and III, 37.0% and the 3-year LC were I, 78.4%; II, 79.8% and III, 65.2%, respectively. Notably, four patients (2.3%) with ≥Grade 3 cardiopulmonary toxicities were observed (Common Terminology Criteria for Adverse Events, version 5.0). Our study showed that particle therapy for esophageal cancer has lower rates of adverse cardiopulmonary events than X-ray radiotherapy.
Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis

Phenotypic variation is of paramount importance in development, evolution, and human health; however, the molecular mechanisms that influence organ shape and shape variability are not well understood. During craniofacial development, the behavior of skeletal precursors is regulated by both biochemical and environmental inputs, and the primary cilia play critical roles in transducing both types of signals. Here, we examine a gene that encodes a key constituent of the ciliary rootlets, crocc2, and its role in cartilage morphogenesis in larval zebrafish.
Low Complexity Regions in Proteins and DNA are Poorly Correlated

Abstract Low complexity sequences (LCRs) are well known within coding as well as non-coding sequences. A low complexity region within a protein must be encoded by the underlying DNA sequence. Here, we examine the relationship between the entropy of the protein sequence and that of the DNA sequence which encodes it. We show that they are poorly correlated whether starting with a low complexity region within the protein and comparing it to the corresponding sequence in the DNA or by finding a low complexity region within coding DNA and comparing it to the corresponding sequence in the protein. We show this is the case within the proteomes of five model organisms: Homo sapiens, Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, and Arabidopsis thaliana. We also report a significant bias against mononucleic codons in LCR encoding sequences. By comparison with simulated proteomes, we show that highly repetitive LCRs may be explained by neutral, slippage-based evolution, but compositionally biased LCRs with cryptic repeats are not. We demonstrate that other biological biases and forces must be acting to create and maintain these LCRs. Uncovering these forces will improve our understanding of protein LCR evolution.
Role of histone H3K4 methyltransferase in regulating Monascus pigments production by red light‐coupled magnetic field

Light, magnetic field, and methylation affected the growth and secondary metabolism of fungi. The regulation effect of the three factors on the growth and Monascus pigments (MPs) synthesis of Monascus purpureus was investigated in this study. 5‐azacytidine (5‐AzaC), DNA methylation inhibitor, was used to treat M. purpureus (wild‐type, WT). Twenty micromolar 5‐AzaC significantly promoted the growth, development, and MPs yield. Moreover, 250 lux red light and red light coupled magnetic field (RLCMF) significantly promoted the biomass. For WT, red light, and RLCMF significantly promoted MPs yield. But compared with red light treatment, only 0.2 mT RLCMF promoted the alcohol‐soluble MPs yield. For histone H3K4 methyltransferase complex subunit Ash2 gene knockout strain (ΔAsh2), only 0.2 mT RLCMF significantly promoted water‐soluble MPs yield. Yet red light, 1.0 and 0.2 mT RLCMF significantly promoted alcohol‐soluble MPs yield. This indicated that methylation affected the MPs biosynthesis. Red light and weaker MF had a synergistic effect on the growth and MPs synthesis of ΔAsh2. This result was further confirmed by the expression of related genes. Therefore, histone H3K4 methyltransferase was involved in the regulation of the growth, development, and MPs synthesis of M. purpureus by the RLCMF.
Health-related quality of life in children, adolescents and young adults with self-harm or suicidality: A systematic review

Objective: Self-harm and suicidality are associated with substantial social and economic burden, especially among children, adolescents and young adults. The aim of this review was to systematically synthesize the literature on the association between health-related quality of life and self-harm/suicidality in children, adolescents and young adults. Methods: Searches were conducted via MEDLINE, PsycINFO, CINAHL, EconLit and EMBASE. Search terms were the combination of the following blocks: (1) self-harm/suicidality, (2) health-related quality of life/well-being/life satisfaction and (3) children/adolescents/young adults. The quality of studies was assessed using the Effective Public Health Practice Project tool. Results: We identified 23 relevant studies. Findings showed that participants who reported self-harm had lower well-being, life satisfaction or overall health-related quality of life compared to those without self-harm. There was also evidence supporting the association between health-related quality of life and suicidal attempt. However, the results for the association with suicidal ideation remained inconsistent. Additionally, mental health, emotional well-being, physical health, oral health, existential well-being and family quality of life were found to be significant domains associated with self-harm or suicidality. Regarding the quality of included studies, 35% (n = 8), 39% (n = 9) and 26% (n = 6) of studies were scored as ‘Strong’, ‘Moderate’ and ‘Weak’, respectively. Conclusion: Findings from the review showed that health-related quality of life varied according to the severity of suicidality (from ideation to attempt). There was also no evidence to infer the direction of causality between health-related quality of life and self-harm/suicidality. The findings suggest a need for further research, in particular longitudinal studies to fill identified gaps in the literature.