Miracle-dz/UniFAR-FTUs huggingface dataset:
The Osteogenic Differentiation of Mesenchymal Stem Cells Derived From Dental Pulp in Modular Alginate-gelatin/nano-hydroxyapatite Microcapsules

Background Microcapsule is considered as a promising 3D microenvironment for Bone Tissue Engineering (BTE) applications. Microencapsulation of cells in an appropriate scaffold not only protects cells against excess stress but also promotes cell proliferation and differentiation. ResultsThe SEM results revealed that Alg/Gel microcapsules containing nHA showed a rough and more compact surface morphology in comparison with the Alg/Gel microcapsules. Moreover, microencapsulation by Alg/Gel/nHA could improve cell proliferation and induce osteogenic differentiation. The cells cultured in the Alg/Gel and Alg/Gel/nHA microcapsules after 21 days showed 1.4-fold and 1.7-fold more activity of BMP-2 gene expression in comparison with the cells cultured on the polystyrene surface as a control group. These amounts for the BMP-2 gene were 2.5-fold and 4-fold more expression for the Alg/Gel and Alg/Gel/nHA microcapsules after 28 days. The nHA addition to hDPSCs-laden Alg/Gel microcapsule could also up-regulate the bone-related gene expressions of osteocalcin, osteonectin, and RUNX-2 during 21 and 28 days culture period. Calcium deposition and ALP activities of the cells were observed in accordance with the proliferation results as well as the gene expression analysis. ConclusionThe study demonstrated that microencapsulation of hDPSCs inside Alg/Gel/nHA hydrogel can be a potential approach for regenerative dentistry in the near future.
Evaluation of the Antifungal Activity of Cinnamon, Clove, Thymes, Zataria Multiflora, Cumin and Caraway Essential Oils against Ochratoxigenic Aspergillus ochraceus

Introduction: Mycotoxin producing fungi are major contributors to food contamination and many epidemics in humans and animals. The adverse effects of the use of chemical preservatives have led to a special focus on the use of natural compounds, especially plant derivatives. The aim of this study was to investigate the antifungal properties of herbal essential oils of Cinnamon, Clove, Thymes, and Zataria multiflora, Cumin, and Caraway on the growth of Aspergillus ochraceus. Materials and Methods: Briefly, the presence of mycotoxin producing gene was investigated using PCR. Furthermore, production of mycotoxin in a medium with high performance liquid chromatography with fluorescence detection (FLD) was evaluated. Ingredients of essential oils were determined using GC/MS. The amount of antifungal activity of essential oils was assessed by disc diffusion and well diffusion method. Additionally, the minimum inhibitory concentration (MIC) was determined by macrodilution method. Results: Gene presence and mycotoxin production were confirmed by PCR and HPLC-FL. Among all studied essential oils, Cinnamon with MIC and MFC of 0.078 μl / ml exhibited the greatest effect on A. ochraceus growth as compared to other essential oils. Conclusion: This study indicated that essential oils have an effective role on controlling A. ochraceus growth and have shown promising to be a good bioactive natural preservative in food industry.
Stability and synchrony across ecological hierarchies in heterogeneous metacommunities: linking theory to data

Understanding stability across ecological hierarchies is critical for landscape management in a changing world. Recent studies showed that synchrony among lower‐level components is key to scaling temporal stability across two hierarchical levels, whether spatial or organizational. But an extended framework that integrates both spatial scale and organizational level simultaneously is required to clarify the sources of ecosystem stability at large scales. However, such an extension is far from trivial when taking into account the spatial heterogeneities in real‐world ecosystems. In this paper, we develop a partitioning framework that bridges variability and synchrony measures across spatial scales and organizational levels in heterogeneous metacommunities. In this framework, metacommunity variability is expressed as the product of local‐scale population variability and two synchrony indices that capture the temporal coherence across species and space, respectively. We develop an R function ‘var.partition’ and apply it to five types of desert plant communities to illustrate our framework and test how diversity shapes synchrony and variability at different hierarchical levels. As the observation scale increased from local populations to metacommunities, the temporal variability of plant productivity was reduced mainly by factors that decreased species synchrony. Species synchrony decreased from local to regional scales, and spatial synchrony decreased from species to community levels. Local and regional species diversity were key factors that reduced species synchrony at the two scales. Moreover, beta diversity contributed to decreasing spatial synchrony among communities. We conclude that our new framework offers a valuable toolbox for future empirical studies to disentangle the mechanisms and pathways by which ecological factors influence stability at large scales.
On the Interpretation of Floatability Using the Bubble Load

Flotation models describe the separability of mineral particles using a loosely defined term known as floatability or probability of collection, a response of particles in the pulp zone of a flotation vessel, unrelated to events in the froth phase. The Bubble Load measurement samples the particles that have attached to bubbles in the pulp zone and, thus, should give an indication of floatability. This thesis investigates the role of floatability in flotation models, and assesses the Bubble Load measurement as a direct estimate of floatability. Towards these ends, continuous pilot-scale flotation tests were carried out in which collector addition rate was varied. This allowed the floatability of mineral particles to be back-calculated on a size-by-liberation basis and be compared to the measured Bubble Load. Contrary to expectations it was found that, with increasing collector addition rate, the “floatability” of a majority of galena particle classes did not increase after 5 mg/kg of collector, while the measured Bubble Load actually decreased. This was found to be due to the stability of the froth increasing with collector addition rate, causing more galena to reach the concentrate, and less to drop-back to the pulp phase to be reattached. Conversely, there were other particle classes (such as sphalerite and coarse galena) where the expected trends were found, namely increasing floatability and Bubble Load with collector addition rate. These results indicate a high level of interdependence between the pulp and froth zones of the studied flotation cell through the flow of material between them (internal reflux). In the case of galena, the flow of material returning via drop-back from the froth had a greater impact on the Bubble Load than the galena in the feed made sufficiently hydrophobic to attach to bubbles. This means that, for the system studied here, the Bubble Load measurement does not provide a direct estimate of mineral particle floatability, defined as a sole consequence of pulp phase events. Moreover, for the current case, it appears that this definition of floatability is not sufficient to capture the interactions between the pulp and the froth. It is recommended that pulp and froth zone flotation models be developed in concert, recognising the interaction between the two zones, and that flotation models be formulated with due allowance for the material transport paths within a flotation vessel. It should be recognised that “floatability” is an aid for the imagination; a term for a process, rather than a particle “property” to be measured. An extension of the kinetic chemical reaction analogue, incorporating flotation sub-processes, is suggested/revived, to give some phenomenological basis to kinetic flotation models.
Complete mitochondrial genome of Formosania chenyiyui (Osteichthyes: Gastromyzontidae)

Abstract The Formosania is only distributed in a narrow area in Southeast China, and differentiation of the species of this genus may be helpful in understanding the formation process of the water system on both sides of the Taiwan Strait. The complete mitochondrial genome of Formosania chenyiyui is sequenced in this paper. The results show that the full length of the complete mitochondrial genome is 16,572 bp, comprising 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and 1 control region. Overall base composition is 30.35% A, 26.68% T, 15.86% G, and 27.11% C. The result of phylogenetic analysis suggests that F. chenyiyui is close to that of F. lacustre and Vanmanenia stenosoma, and accords with the evolutionary viewpoint of Formosaniini group based on morphological characteristics.
Life Cycle of Heterodera glycines in Resistant and Susceptible Soybean

The life cycle of the soybean cyst nematode lasts approximately 21-24 days at temperatures ranging from 23 °C to 25 °C. Mean temperatures above 25 °C are often found in Goiás State and in other Brazilian regions. Thus, the aim of the present study is to assess the penetration and cycle duration of Heterodera glycines Type 0- (race 3) in nematode-resistant and susceptible soybean cultivars grown in greenhouse under controlled conditions. The study was conducted at soil temperatures ranging from 23.9 °C to 31.1 °C using two soybean cultivars that were assessed in ten different periods; each assessment was conducted in six plants. The herein used soybean cultivars were BRS Valiosa RR and BRSGO 8860RR, which were, respectively, susceptible and resistant to the nematode. Root staining assessments were performed 2, 4, 6, 9, 12, 15, 18, 21, 24 and 30 days after inoculation (DAI). Besides the root staining assessments, the females and eggs were also assessed through extraction using the sieving and flotation method, at the 30th DAI. Heterodera glycines J2 penetration was similar in both the susceptible and the resistant cultivars throughout the assessment period. It indicates that the nematode penetration was not affected by resistance. The Heterodera glycines cycle at soil temperature ranging from 23.9 °C to 31.1 °C and at room temperature ranging from 27.0 °C to 36.3 °C was complete in 15 days, in both the susceptible and the resistant cultivars. A similar number of J2 has penetrated the roots of both cultivars and greater penetration intensity was found from the 6th to the 15th DAI. The peak J3, J4 and female formation period in the resistant cultivar was later than that observed in the susceptible cultivar.
Long term beef production in extensive cow-calf systems in the tropical savannas of eastern Colombia

Las novillas de reemplazo en los sistemas extensivos de cria de los Llanos Orientales de Colombia son animales de baja prioridad para el productor, y generalmente se les asigna sabanas nativas o pasturas de baja calidad. Las consecuencias de dicha estrategia de manejo han sido poco investigadas. El trabajo reunio datos de cuatro experimentos de pastoreo contemporaneos y de largo plazo para estimar los efectos de bajas tasas de crecimiento sobre las ganancias de peso por ano y por hectarea (ha) de novillas sometidas a diferentes estrategias de manejo. Se usaron tres cargas animales durante la fase de crecimiento para lograr tasas de crecimiento contrastantes entre los nueve y 36 meses de edad usando pasturas de baja calidad de Brachiaria humidicola caracterizadas por bajo contenido de proteina bruta y digestibilidad. Durante la fase de cria y reproduccion pasaron a pasturas de B. humidicola o de B. decumbens con cargas reducidas, para permitir ganancias de peso compensatorias. Los animales de menor ganancia durante el crecimiento no lograron ganancias compensatorias que les permitieran alcanzar a aquellos mejor alimentados. Independientemente de la estrategia de alimentacion, anos de relativamente alta produccion fueron seguidos por anos de baja produccion en forma ciclica. La comparacion con animales mejor alimentados mantenidos en pastura de B. decumbens bien manejada mostro diferencias considerables y significativas acumuladas durante su vida util. A lo largo de nueve anos de experimentacion, la produccion de ganancia de peso de vacas mas terneros destetos vario entre 86 y 206 kg/ha/ano, demostrando las consecuencias de largo plazo del amplio rango de estrategias de manejo experimentadas. La produccion de carne en estos sistemas puede ser aumentada si se le suma el peso de vacas de descarte, particularmente, si le les permite un periodo de ceba corto durante la estacion lluviosa usando aun pasturas de calidad baja.
Religijność a kompetencje kulturowe pielęgniarek w kontekście przeobrażeń społecznych

Czasopismo Open Access, wszystkie artykuły udostępniane są na mocy licencji Creative Commons Uznanie autorstwa-użycie niekomercyjne-na tych samych warunkach 4.0 Międzynarodowe (CC BY-NC-SA 4.0, http://creativecommons.org/licenses/by-nc-sa/4.0/). Wkład autorów/ Authors’ contribution: A. Zaplanowanie badań/ Study design B. Zebranie danych/ Data collection C. Dane – analiza i statystyki/ Data analysis D. Interpretacja danych/ Data interpretation E. Przygotowanie artykułu/ Preparation of manuscript F. Wyszukiwanie i analiza literatury/ Literature analysis G. Zebranie funduszy/ Funds collection Streszczenie Cel pracy. Głównym celem pracy było wskazanie związku pomiędzy religijnością, a kompetencjami kulturowymi pielęgniarek. Materiał i metody. Badania przeprowadzono w grupie 238 pielęgniarek za pomocą walidowanej skali Nurse Cultural CompetenceScale (NCCS) autorstwa Perng S. i Watson R. oraz skali Twoja Religijność autorstwa Socha P. Wyniki. Badania własne za pomocą zwalidowanej wersji skali P-NCCS wykazały przeciętny poziom kompetencji kulturowych pielęgniarek. Najniższe wyniki odnotowano w zakresie Skali Wrażliwości Kulturowej (M=29, 83). Wśród badanej grupy największe nasilenie orientacji religijnej było w zakresie podskali Poszukująca Orientacja Religijna (M=35, 90) . Wykazano, że im wyższa Zewnętrzna Orientacja Religijna oraz Poszukująca Orientacja Religijna, tym istotnie wyższy poziom wybranych wskaźników kompetencji kulturowych. Wnioski. Badania wykazały, że pielęgniarki z wysokim poziomem religijności cechuje wyższy wskaźnik kompetencji kulturowych oraz wcześniejsze doświadczenia w sprawowaniu opieki nad pacjentem odmiennym kulturowo pomagają w budowaniu kompetencji kulturowych
Mid-level bureaucrats perception on the implementation of public policies

Resumo Este artigo busca contribuir com os estudos sobre as percepções de Burocratas de Médio Escalão (BMEs) na implementação de uma política pública. Para tanto, analisam-se empiricamente as percepções dos BMEs na implementação do Programa de Apoio a Planos de Reestruturação e Expansão das Universidades Federais (Reuni) no âmbito da Universidade Federal de Goiás (UFG). Realizou-se um estudo de caso, mediante pesquisa documental e entrevistas com esses burocratas. Os resultados demonstram a importância de que o BME tenha apoio institucional e preparação técnica e emocional para realizar um bom trabalho. Em termos empíricos, demonstra-se que a UFG não conseguiu atender às metas globais do Reuni, porém, cumpriu a maioria das diretrizes estipuladas pelo Ministério da Educação (MEC) em decreto, com destaque para a ampliação de políticas de inclusão e assistência estudantil, transformando uma universidade “elitizada” em uma universidade “igualitária”. De modo unânime, os BMEs reconhecem a grande importância do Reuni na UFG, em termos estruturais e de ensino, e que sua atuação poderia ter sido mais bem desempenhada com suporte e preparação adequados.
Deep Sequence Modeling: Development and Applications in Asset Pricing

The authors predict asset returns and measure risk premiums using a prominent technique from artificial intelligence: deep sequence modeling. Because asset returns often exhibit sequential dependence that may not be effectively captured by conventional time-series models, sequence modeling offers a promising path with its data-driven approach and superior performance. In this article, the authors first overview the development of deep sequence models, introduce their applications in asset pricing, and discuss their advantages and limitations. They then perform a comparative analysis of these methods using data on US equities. They demonstrate how sequence modeling benefits investors in general through incorporating complex historical path dependence and that long short-term memory–based models tend to have the best out-of-sample performance. TOPICS: Big data/machine learning, security analysis and valuation, performance measurement Key Findings ▪ This article provides a concise synopsis of deep sequence modeling with an emphasis on its historical development in the field of computer science and artificial intelligence. It serves as a reference source for social scientists who aim to use the tool to supplement conventional time-series and panel methods. ▪ Deep sequence models can be adapted successfully for asset pricing, especially in predicting asset returns, which allow the model to be flexible to capture the high-dimensionality, nonlinear, interactive, low signal-to-noise, and dynamic nature of financial data. In particular, the model’s ability to detect path-dependence patterns makes it versatile and effective, potentially outperforming existing models. ▪ This article provides a horse-race comparison of various deep sequence models for the tasks of forecasting returns and measuring risk premiums. Long short-term memory has the best performance in terms of out-of-sample predictive R2, and long short-term memory with an attention mechanism has the best portfolio performance when excluding microcap stocks.
EFFECT OF HERBS ON PRODUCTIVE PERFORMANCE OF LAYING HENS, SOME BLOOD CONSTITUENTS AND ANTIOXIDANT ACTIVITYIN EGG YOLK

The present study aimed to evaluate the comparative effect of ginger, cinnamon, thyme, cumin black seed and pomegranate peels on productive performance, egg quality and some blood constituents of laying hens. Ninety white Hi-Sex layers at 30 week of age were randomly allocated into six treatment groups for ten weeks experimental period. The layers groupsfed six different diets as, basal diet (T1, control)or basal diets supplemented with 1% of five different dried herbal plants , cumin black seeds (T2), thyme (T3), cinnamon (T4), ginger (T5) and pomegranate peels (T6). Thyme wasthe most effective supplementation in improving egg production followed by cinnamon. Average egg weight reduced significantly by feeding dietary thyme, cinnamon, ginger or pomegranate peels. Herbal plants have no significant (P≤ 0.05) effects on feed consumption or feed conversion ratio. The percentages of egg yolk, albumin or egg shell did not differ due to treatments. There were reductions in plasma and yolk levels of total cholesterol and LDL. Total phenolic content in different herbs were significantly similar. Free radical scavenging capacity (DPPH reduction %) was approximately similar for different herbs plants, and in egg yolk. Egg yolk contents of carotenoids increased significantly due to inclusion different herbal plants into laying hens diets. It can be concluded that, herbal plants can be employed as natural antioxidants due to its high contents of phenols. As well, inclusion of herbal plants into hen diets can improve the nutritive values of produced eggs via increasing its content of carotenoids and antioxidants.
Probable immersions for novel Coronavirus and its preventions: A systematic review

The new public health crisis threatening the world with the emergence due to the spreading of 2019 novel coronavirus (2019-nCoV) or it can also say as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus instigated in bats and was transmitted to humans through yet unknown transitional animals in Wuhan, Hubei province, China in December 2019. There have been around 3.04 million reported cases by WHO of coronavirus disease 2019 (COVID-2019) and 895 thousand are recovered, 211 thousand reported deaths to date (28/04/2020) from all over the world. The disease is spread by inhalation/breathing or interaction with infected droplets. The quarantine period ranges from 2 to 14 days. The symptoms are typically breathlessness, cough, sore throat, fever, fatigue, malaise, among others. The disease is mild in most people; while in about some (generally the aged and those with comorbidities), it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi-organ dysfunction. Many people are asymptomatic. Treatment is very essentially supportive; the role of antiviral agents is up till now to be recognized. Prevention requires home quarantine of alleged cases and those with mild illnesses and severe infection control measures at hospitals that contain interaction, touch and droplet precautions.
Aging alters the role of basolateral amygdala in intertemporal choice

Aging is associated with an increased ability to delay gratification. Moreover, even when matched for performance, young and aged subjects recruit distinct brain circuitry to complete complex cognitive tasks. Experiments herein used an optogenetic approach to test whether altered recruitment of the basolateral amygdala (BLA), a brain region implicated in valuation of reward-cost contingencies, contributes to age-dependent changes in intertemporal decision making. BLA inactivation while rats deliberated prior to choices between options that yielded either small, immediate or large, delayed rewards rendered both young and aged rats less impulsive. In contrast, BLA inactivation after choices were made (during evaluation of choice outcomes) rendered young rats more impulsive but had no effect in aged rats. These data define multiple, temporally-discrete roles for BLA circuits in intertemporal decision making and implicate altered recruitment of BLA in the elevated preference for delayed rewards that is characteristic of advanced age. Impact Statement Basolateral amygdala (BLA) performs multiple, temporally-discrete functions during intertemporal decision making. Differential engagement of BLA contributes to the enhanced ability to delay gratification that is characteristic of advanced ages.
Regulatory role of sorting nexin 5 in protein stability and vesicular targeting of vesicular acetylcholine transporter to synaptic vesicle-like vesicles in PC12 cells

Accurate targeting of vesicular acetylcholine transporter (VAChT) to synaptic vesicles (SVs) is indispensable for efficient cholinergic transmission. Previous studies have suggested that the dileucine motif within the C-terminus of the transporter is sufficient for its targeting to SVs. However, the cytosolic machinery underlying specific regulation of VAChT trafficking and targeting to SVs is still unclear. Here we used the C-terminus of VAChT as a bait in a yeast two-hybrid screen to identify sorting nexin 5 (SNX5) as its novel interacting protein. SNX5 was detected in the SVs enriched LP2 subcellular fraction of rat brain homogenate and showed strong colocalization with VAChT in both brain sections and PC12 cells. Binding assays suggested that the C-terminal domain of VAChT can interact with both BAR and PX domain of SNX5. Depletion of SNX5 enhanced the degradation of VAChT and the process was mediated through the lysosomal pathway. More importantly, we found that, in PC12 cells, the depletion of SNX5 expression significantly decreased the synaptic vesicle-like vesicles (SVLVs) localization of VAChT. Therefore, the results suggest that SNX5 is a novel regulator for both stability and SV targeting of VAChT.