Miracle-dz/UniFAR-FTUs huggingface dataset:
Coarse-to-Fine Hand–Object Pose Estimation with Interaction-Aware Graph Convolutional Network

The analysis of hand–object poses from RGB images is important for understanding and imitating human behavior and acts as a key factor in various applications. In this paper, we propose a novel coarse-to-fine two-stage framework for hand–object pose estimation, which explicitly models hand–object relations in 3D pose refinement rather than in the process of converting 2D poses to 3D poses. Specifically, in the coarse stage, 2D heatmaps of hand and object keypoints are obtained from RGB image and subsequently fed into pose regressor to derive coarse 3D poses. As for the fine stage, an interaction-aware graph convolutional network called InterGCN is introduced to perform pose refinement by fully leveraging the hand–object relations in 3D context. One major challenge in 3D pose refinement lies in the fact that relations between hand and object change dynamically according to different HOI scenarios. In response to this issue, we leverage both general and interaction-specific relation graphs to significantly enhance the capacity of the network to cover variations of HOI scenarios for successful 3D pose refinement. Extensive experiments demonstrate state-of-the-art performance of our approach on benchmark hand–object datasets.
Victimization experience does matter: Testing the effect of different types of victimization on fear of crime among adolescents

The aim of the present study is to thoroughly examine the relationship between adolescent fear of crime and a wide variety of offences which commonly affect children. The analysed data comes from the Urban Youth Victimization Survey conducted among 9th grade students in the Czech Republic. The results unequivocally demonstrate that victimization experience, when measured properly, substantially affects adolescent fear of crime. All analysed types of victimization are associated with fear of crime, though the strongest effects were found for cyber-victimization and bullying rather than conventional violent and property crimes. Furthermore, a poly-victimization scale was revealed to be a highly effective tool for capturing overall victimization by using a single summary measure.
Positive Effects of Blue Light on Postural Control and Motor Coordination in Older Adults: A Pilot Study

Purpose: Falls are a risk factor for mortality in older adults. Light interventions can improve cognitive function and performance in motor tasks, but the potential impact on postural control with relevance to falling is unknown. This study aimed to examine the effect of light on postural control, motor coordination, and cognitive functioning. Methods: Sixteen older adults participated in an intervention study that involved four counter-balanced sessions with blue-enriched light delivered visually and/or transcranially for 12 minutes. Postural control in three conditions (60 s eyes open, dual-task, and eyes closed), lower extremity motor coordination, and cognitive function were assessed. Area of sway (AoS), coordination, and cognitive function were compared between the groups via repeated-measured ANOVA. Results: Relative to placebo, visual blue-enriched light exposure clearly decreased AoS (d = 0.68 ±0.73; p =0.166) and improved reaction time in the motor coordination task (d = 1.44 ±0.75; p =0.004); however, no significant effect was seen on cognitive function. Conclusion Blue-enriched light demonstrates a novel clinical approach to positively impact on postural control and lower-limb motor coordination in older adults. By impacting on metrics associated with fall risk, blue-enriched light may provide a clinically meaningful countermeasure to decrease the human costs of falls.
Psychological pathways between type D personality and COVID-19

BACKGROUND Patients with a type D personality have worse social functioning and mental health and more affective constraints than non-type D personalities. They have a negative outlook on life and health-related issues. The aim of this study was to examine the mediating role of stress and anxiety in the relationship between type D personality and COVID-19 by adjustment of the effect of demographic characteristics and perceived symptoms as confounder variables. PARTICIPANTS AND PROCEDURE A total of 196 patients out of those suspected of having COVID-19 and visiting the reference hospitals were selected. They had completed the type D personality and the anxiety and stress scales along with their hospital admission form before undergoing COVID-19 testing. After their COVID-19 test, the participants were divided into two groups based on their disease, an infected group (n = 90) and a non-infected group (n = 106). RESULTS Type D personality has no significant direct effect on infection with the disease, but taking into account the mediating variable of stress, the odds of an event in those with type D personality is 2.21 times higher than those without this personality (p = .027) and, taking into account the mediating variable of anxiety, having a type D personality increases the odds of an event by 2.62 times (p = .011), holding demographic characteristics and perceived symptoms constant. CONCLUSIONS Given the indirect relationship between COVID-19 and type D personality, the mediating variables of stress and anxiety can be considered full mediating variables.
Utility system demonstration of six phase power transmission

A viable option which can be considered by utility system planners in implementing the addition of over 13000 circuit miles of transmission lines currently being forecast over the next ten years is presented. The option is high phase order (HPO) transmission or the transmission of power utilizing six phases or more. What makes this subject unique is that the concept of HPO transmission, more specifically six-phase power transmission, is for the first time being commercially demonstrated. The background in previous HPO research is discussed. The need for a six-phase demonstration project is identified. Methodologies to address the uprating of double circuit lines, the impact of the six phase demonstration project on utility substations, and tests planned for the demonstration phase are detailed. The issues presented are within the context of the work completed and currently underway on the New York State Electric and Gas Corporation's (NYSEG's) Goudey-Oakdale transmission line. This work, when completed, will represent a significant contribution to the power industry in taking a new technology from concept to commercial viability. <<ETX>>
Flow Around and Forces on a Pipeline Near a Scoured Bed in Steady Current

Flow around a pipeline placed initially on a flat, erodible bed was investigated at five characteristic stages of the progressive scour process in currents. The velocities, both in the streamwise direction and in the direction normal to the bed, were measured. A two-color flow visualization technique was used to detect the time-dependent flow structures. The forces on the cylinder were recorded simultaneously with the flow visualization. In the theoretical part of the study, a discrete vortex model (namely, the cloud-in-cell model) is employed to predict the flow. The early results appear to reveal the gross features of the flow shown by the experiments.
Abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in melancholic depression

Abstract Background Previous studies have demonstrated structural and functional changes of the hippocampus in patients with major depressive disorder (MDD). However, no studies have analyzed the dynamic functional connectivity (dFC) of hippocampal subregions in melancholic MDD. We aimed to reveal the patterns for dFC variability in hippocampus subregions – including the bilateral rostral and caudal areas and its associations with cognitive impairment in melancholic MDD. Methods Forty-two treatment-naive MDD patients with melancholic features and 55 demographically matched healthy controls were included. The sliding-window analysis was used to evaluate whole-brain dFC for each hippocampal subregions seed. We assessed between-group differences in the dFC variability values of each hippocampal subregion in the whole brain and cognitive performance on the MATRICS Consensus Cognitive Battery (MCCB). Finally, association analysis was conducted to investigate their relationships. Results Patients with melancholic MDD showed decreased dFC variability between the left rostral hippocampus and left anterior lobe of cerebellum compared with healthy controls (voxel p < 0.005, cluster p < 0.0125, GRF corrected), and poorer cognitive scores in working memory, verbal learning, visual learning, and social cognition (all p < 0.05). Association analysis showed that working memory was positively correlated with the dFC variability values of the left rostral hippocampus-left anterior lobe of the cerebellum (r = 0.338, p = 0.029) in melancholic MDD. Conclusions These findings confirmed the distinct dynamic functional pathway of hippocampal subregions in patients with melancholic MDD, and suggested that the dysfunction of hippocampus-cerebellum connectivity may be underlying the neural substrate of working memory impairment in melancholic MDD.
Sequences of seismic and aseismic slip on bimaterial faults show dominant rupture asymmetry and potential for elevated seismic hazard

We perform numerical simulations of sequences of earthquake and aseismic slip on planar rate and state faults separating dissimilar material within the 2-D plane strain approximation. We resolve all stages of the earthquake cycle from aseismic slip to fast ruptures while incorporating full inertia effects during seismic event propagation. We show that bimaterial coupling results in favorable nucleation site and subsequent asymmetric rupture propagation. We demonstrate that increasing the material contrast enhances this asymmetry leading to higher slip rates and normal stress drops in the preferred rupture propagation direction. The normal stress drop, induced by the bimaterial effect, leads to strong dynamic weakening of the fault and may destabilize the creeping region on a heterogeneous rate and state fault, resulting in extended rupture propagation. Such rupture penetration into creeping patches may lead to more frequent opening of earthquake gates, causing increased seismic hazard. Furthermore, bimaterial coupling may lead to irregular seismicity pattern in terms of event length, peak slip rates,and hypocenter location, depending on the properties of the creeping patches bordering the seismogenically active part of the fault . Our results highlight robust characteristics of bimaterial interfaces that persist over long sequence of events and suggest the need for further exploration of the role of material contrast in earthquake physics and models of seismic hazard.
The Functional Role of IgA in the IgM/IgA-Enriched Immunoglobulin Preparation Trimodulin

In comparison to human immunoglobulin (Ig) G, antibodies of IgA class are not well investigated. In line with this, the functional role of the IgA component in IgM/IgA-enriched immunoglobulin preparations is also largely unknown. In recent years, powerful anti-pathogenic and immunomodulatory properties of human serum IgA especially on neutrophil function were unraveled. Therefore, the aim of our work is to investigate functional aspects of the trimodulin IgA component, a new plasma-derived polyvalent immunoglobulin preparation containing ~56% IgG, ~23% IgM and ~21% IgA. The functional role of IgA was investigated by analyzing the interaction of IgA with FcαRI, comparing trimodulin with standard intravenous IgG (IVIG) preparation and investigating Fc receptor (FcR)-dependent functions by excluding IgM-mediated effects. Trimodulin demonstrated potent immunomodulatory, as well as anti-pathogenic effects in our neutrophil model (neutrophil-like HL-60 cells). The IgA component of trimodulin was shown to induce a strong FcαRI-dependent inhibitory immunoreceptor tyrosine-based activation motif (ITAMi) signaling, counteract lipopolysaccharide-induced inflammation and mediate phagocytosis of Staphylococcus aureus. The fine-tuned balance between immunomodulatory and anti-pathogenic effects of trimodulin were shown to be dose-dependent. Summarized, our data demonstrate the functional role of IgA in trimodulin, highlighting the importance of this immunoglobulin class in immunoglobulin therapy.
The Curious Case of the HepG2 Cell Line: 40 Years of Expertise

Liver cancer is the third leading cause of cancer death worldwide. Representing such a dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable and reliable methods for preventing and treating liver cancer require fundamental research on its molecular mechanisms. Cell lines are treated as in vitro equivalents of tumor tissues, making them a must-have for basic research on the nature of cancer. According to recent discoveries, certified cell lines retain most genetic properties of the original tumor and mimic its microenvironment. On the other hand, modern technologies allowing the deepest level of detail in omics landscapes have shown significant differences even between samples of the same cell line due to cross- and mycoplasma infection. This and other observations suggest that, in some cases, cell cultures are not suitable as cancer models, with limited predictive value for the effectiveness of new treatments. HepG2 is a popular hepatic cell line. It is used in a wide range of studies, from the oncogenesis to the cytotoxicity of substances on the liver. In this regard, we set out to collect up-to-date information on the HepG2 cell line to assess whether the level of heterogeneity of the cell line allows in vitro biomedical studies as a model with guaranteed production and quality.
The Effects of Age, Dosage, and Poverty on Second Language Learning through SparkLingTM in Infant Education Centers in Madrid, Spain

The first 1000 days represent a unique window of opportunity for second language learning. In two recent studies we demonstrated that Spanish infants’ use of second-language (L2) English productive vocabulary and early utterances rapidly increased through the play-based, interactive and highly social SparkLingTM Intervention, which consists of an evidence-based method and curriculum stemming from decades of research on infant language development. Analyzing an expanded and more diverse sample of Spanish infants (n = 414; age 9–33 months) who received the SparkLingTM Intervention, this study examines the variability in L2 production, which was assessed via first-person LENA audio recordings. Infants’ age significantly and positively correlated with L2 production, demonstrating an advantage for older infants in the sample. While overall socioeconomic status (SES) was not related to L2 production, very young infants (under two years) who lived in high poverty homes showed faster increases in English production compared to peers who lived in moderate poverty homes. Infants’ attendance in the program (“dosage”) was also predictive of their L2 production outcomes. Infants across SES have the capacity to begin acquiring two languages in early education classrooms with SparkLingTM through one-hour/day sessions in social environments that engages them through frequent high-quality language input.
EFFECTS OF DENTAL IMPLANT LENGTH AND BONE QUALITY ON BIOMECHANICAL RESPONSES IN BONE AROUND IMPLANTS: A 3-D NON-LINEAR FINITE ELEMENT ANALYSIS

The aim of this study was to evaluate the influence of implant length and bone quality on the biomechanical aspects in alveolar bone and dental implant using non-linear finite element analysis. Two fixture lengths (8 and 13mm) of Frialit-2 root-form titanium implants were buried in 4 types of bone modeled by varying the elastic modulus for cancellous bone. Contact elements were used to simulate the realistic interface fixation within the implant system. Axial and lateral (buccolingual) loadings were applied at the top of the abutment to simulate the occlusal forces. The simulated results indicated that the maximum strain values of cortical and cancellous bone increased with lower bone density. In addition, the variations of cortical bony strains between 13mm and 8mm long implants were not significantly as a results of the same contact areas between implant fixture and cortical bone were found for different implant lengths. Lateral occlusal forces significantly increased the bone strain values when compared with axial occlusal forces regardless of the implant lengths and bone qualities. Loading conditions were found as the most important factor than bone qualities and implant lengths affecting the biomechanical aspects for alveolar bone and implant systems. The simulated results implied that further understanding of the role of occlusal adjustment influencing the loading directions are needed and might affect the long-term success of an implant system.
In-Flight Icing Risk Management Through Computational Fluid Dynamics-Icing Analysis

In thiswork, an in-depth analysis of the occurrence of in-flight icing accidents and incidents is conducted to identify high-risk flight conditions. These conditions are investigatedmore thoroughly using a computational fluid dynamics model of a representative airfoil. This model permits the recreation of experiments conducted in the controlled environment of the icing wind tunnel. The ice accumulations and resulting aerodynamic performance degradations of the airfoil are computed for a range of pitch angles and flight speeds. These simulations reveal substantial performance losses such as reduced maximum lift, and decreased stall angle. From these results, an icing hazard analysis tool is developed, using risk management principles, to evaluate the dangers of in-flight icing for a specific aircraft based on the atmospheric conditions it is expected to encounter, as well as the effectiveness of aircraft certification procedures.
Farm- and community-level factors underlying the profitability of fertiliser usage for Ethiopian smallholder farmers

ABSTRACT While adoption rates for inorganic fertiliser are relatively high in Ethiopia, application rates are generally considered agronomically suboptimal. Using recent data on Ethiopian smallholder maize producers, we showed that maize response to nitrogen, and the profitability of fertiliser use depended on maize agronomy. The agronomic optimum ranged from 0 to 344 kg/ha with a mean value of 209 kg/ha. The actual nitrogen application rates were only about half the agronomic optimum, on average, and were less than the farm-specific economic optimum on 80% of maize fields. The average economic optimum level was 145 kg N/ha, but when we account for risk aversion, the resulting average optimum level is very close to the average observed usage level of 88 kg N/ha. Addressing risk aversion may help to induce greater levels of fertiliser investments at current prices and yield response rates. Our analysis also suggests that key pathways for increasing the economic returns to smallholder fertiliser investments include: complementing nitrogen inputs with phosphorus inputs and improved varieties, using lower levels of nitrogen under intercropping and manure inputs, enabling farmers to delay output sales beyond the immediate post-harvest period, and lowering the costs of accessing input and output markets.
The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana

DNA entanglements and supercoiling arise frequently during normal DNA metabolism. DNA topoisomerases are highly conserved enzymes that resolve the topological problems that these structures create. Topoisomerase II (TOPII) releases topological stress in DNA by removing DNA supercoils through breaking the two DNA strands, passing a DNA duplex through the break and religating the broken strands. TOPII performs key DNA metabolic roles essential for DNA replication, chromosome condensation, heterochromatin metabolism, telomere disentanglement, centromere decatenation, transmission of crossover (CO) interference, interlock resolution and chromosome segregation in several model organisms. In this study, we reveal the endogenous role of Arabidopsis thaliana TOPII in normal root growth and cell cycle, and mitotic DNA repair via homologous recombination. Additionally, we show that the protein is required for meiotic DSB repair progression, but not for CO formation. We propose that TOPII might promote mitotic HR DNA repair by relieving stress needed for HR strand invasion and D-loop formation.
Pothole Detection Using Advanced Neural Networks

A pothole is one among the first reasons for road accidents and is becoming increasingly important to detect while driving on roads. Detection and warning can significantly reduce accidents and damages caused to vehicles. Advanced neural networks process the pictures from the camera on a realtime basis to spot if there is a pothole within the image. Detection of potholes using neural networks will be time-consuming. Recently, the advances in artificial neural network have led to varied high-performance single-shot detection algorithms. These algorithms are especially useful in real-time applications. Hence, in this paper, we present a study of various object detection algorithms towards pothole detection with its speed and accuracy. The dataset comprises around 9000 training images with and without potholes. The article analyzes Yolo V3, Yolo V4, Yolo V5, and SSD algorithms to judge the results with the identical dataset for training and evaluation.
HRMS Characterization, Antioxidant and Cytotoxic Activities of Polyphenols in Malus domestica Cultivars from Costa Rica

There is increasing interest in research into fruits as sources of secondary metabolites because of their potential bioactivities. In this study, the phenolic profiles of Malus domestica Anna and Jonagold cultivars from Costa Rica were determined by Ultra Performance Liquid Chromatography coupled with High Resolution Mass Spectrometry (HRMS) using a quadrupole-time-of-flight analyzer (UPLC-QTOF-ESI MS), on enriched-phenolic extracts from skins and flesh, obtained through Pressurized Liquid Extraction (PLE). In total, 48 different phenolic compounds were identified in the skin and flesh extracts, comprising 17 flavan-3-ols, 12 flavonoids, 4 chalcones, 1 glycosylated isoprenoid and 14 hydroxycinnamic acids and derivatives. Among extracts, the flesh of Jonagold exhibits a larger number of polyphenols and is especially rich in procyanidin trimers, tetramers and pentamers. Evaluating total phenolic content (TPC) and antioxidant activities using ORAC and DPPH procedures yields higher values for this extract (608.8 mg GAE/g extract; 14.80 mmol TE/g extract and IC50 = 3.96 µg/mL, respectively). In addition, cytotoxicity evaluated against SW620 colon cancer cell lines and AGS gastric cancer cell lines also delivered better effects for Jonagold flesh (IC50 = 62.4 and 60.0 µg/mL, respectively). In addition, a significant negative correlation (p < 0.05) was found between TPC and cytotoxicity values against SW620 and AGS adenocarcinoma (r = −0.908, and −0.902, respectively). Furthermore, a significant negative correlation (p < 0.05) was also found between the number of procyanidins and both antioxidant activities and cytotoxicity towards SW620 (r = −0.978) and AGS (r = −0.894) cell lines. These results align with Jonagold flesh exhibiting the highest abundance in procyanidin oligomers and yielding better cytotoxic and antioxidant results. In sum, our findings suggest the need for further studies on these Costa Rican apple extracts—and particularly on the extracts from Jonagold flesh—to increase the knowledge on their potential benefits for health.