Miracle-dz/UniFAR-FTUs huggingface dataset:
Combined radiofrequency ablation or microwave ablation with transarterial chemoembolization can increase efficiency in intermediate-stage hepatocellular carcinoma without more complication: a systematic review and meta-analysis

Abstract Objectives Radiofrequency ablation (RFA) and microwave ablation (MWA) are widely used in combination with transarterial chemoembolization (TACE) for intermediate-stage hepatocellular carcinoma (HCC) in clinical practice. We aim to compare the efficacy and safety of TACE combined with RFA or MWA versus TACE monotherapy for intermediate-stage HCC. Methods We searched PubMed, Embase, Web of Science, and the Cochrane Library for relevant studies. The outcomes included overall survival (OS), progression-free survival (PFS), local tumor control (LTC) rate, and major complication. Subgroup analysis for different TACE combination therapies was performed. Results Ten studies with 1799 patients with intermediate-stage HCC were included. The pooled hazard ratio (HR) for OS was in favor of TACE combination therapy (HR, 0.50, 95% confidence interval [CI], 0.40–0.62). Specifically, the TACE combination therapy was associated with higher 1-, 3-, and 5-year OS rates. Regarding tumor progression, the TACE combination therapy showed significantly better PFS (HR, 0.47, 95% CI, 0.37–0.61) and higher 1-, 2- and 3-year PFS rates than TACE monotherapy. The pooled odds ratio (OR) for the LTC was also in favor of TACE combination therapy (OR, 0.36, 95% CI, 0.24–0.53). No significant difference was found between the two groups regarding the major complication rate (OR, 1.26, 95% CI, 0.74–2.16). These results were consistent across subgroups of TACE + RFA versus TACE and TACE + MWA versus TACE. Conclusion TACE combined with RFA or MWA can provide significantly better OS, PFS and LTC than TACE monotherapy for patients with intermediate-stage HCC, without increasing the risk of major complications.
An assessment of the effectiveness of oral health education on oral health-related knowledge and attitudes of caregivers of children with hearing impairment.

AIM To assess the effectiveness of oral health education on oral health-related knowledge and attitudes of caregivers of children with hearing impairment and its impact on the oral health status of their children. MATERIALS Study design: Non randomised pre- and post-comparison study. Fifty-six pairs of caregiver-child with sensory impairment were chosen and divided into study and control groups. Health education was provided to the caregivers of the study group for 1, 3, 6 and 12-month period and periodic assessment of their knowledge, attitudes and practices (KAP) was performed. The caregivers of the control group did not receive any oral health education during the study period. The oral health status of these children was evaluated using the WHO assessment form (2013) and modified OHI-S (oral hygiene index- simplified) at baseline, 6 month and 12-month period. The effectiveness of KAP of caregivers and the oral health status of their children was correlated at the end of the study. STATISTICAL ANALYSIS The mean KAP scores between caregivers' of study and control group at different time intervals was compared using repeated measures of ANOVA test. Chi square test was used to compare the presence of bleeding gums and Mann Whitney U Test was used to compare the mean DMFT, deft and OHIs scores at different time intervals between study and control groups. Pearson correlation test was used to assess the relationship between KAP scores and clinical parameters at different time intervals in study and control group of both the populations. CONCLUSION The oral health education given to the caregivers has shown a positive impact on the oral health status of their children. Periodic reinforcement of the oral health-related measures among caregivers of children with hearing impairment is recommended.
Breeding ecology of Rufous Potoo Nyctibius bracteatus in central Amazonian Brazil

Summary. The smallest potoo, Rufous Potoo Nyctibius bracteatus is a little-known and inconspicuous species of the understorey in Amazonian terra firme forests, where it roosts by day. Currently, there are few published observations describing its natural history and reproductive ecology. We present data on nest and egg characteristics, nestling appearance, behaviour and development, and parental care, based on three different nests in three consecutive years at Reserva Florestal Adolpho Ducke, Manaus, central Amazonian Brazil. All nests had similar characteristics and the single egg at one nest was cream-coloured with brown spots. The young at one nest fledged when c.40 days old, but the other two nests were both predated by ant swarms, constituting the first report of such predation in the Nyctibiidae.
Fregetta lineata (Peale, 1848) is a valid extant species endemic to New Caledonia

Summary. We present evidence that confirms the streaked Fregetta lineata is a valid extant species that breeds on New Caledonia and endorse the vernacular name New Caledonian Storm Petrel. We review taxonomic deliberations over the historic five ‘Pealea’ streaked storm petrel specimens. Three belong to the recently rediscovered New Zealand Storm Petrel F. maoriana. We study six biometrics of the other two identical-looking specimens, one from Samoa, the other from the Marquesas Islands, a third ‘new’ specimen collected off Brisbane, and other Fregetta taxa. Results of Principal Component Analyses, Discriminant Analyses, and a review of phylogenetic relationships between Fregetta storm petrels, F. lineata and F. maoriana, lead us to conclude that the three specimens represent a single taxon, F. lineata. Furthermore, F. lineata is clearly separated from F. maoriana, White-bellied Storm Petrel F. grallaria and Black-bellied Storm Petrel F. tropica. We further conclude that storm petrels photographed at sea, off New Caledonia and in the Coral Sea, are F. lineata. We then redescribe F. lineata from at-sea observations, photographs taken at sea, and study of the three museum specimens. Criteria for in-hand and at-sea identification are presented. We report the first breeding record, from New Caledonia, a grounded fledgling presumably disoriented by onshore artificial lights. We explore likely breeding locations and conservation issues.
Fatal infection with Versteria sp. in a muskrat, with implications for human health

The Taeniidae tapeworms are a family of helminths that have a similar life cycle, with intermediate hosts developing characteristic cysts in visceral organs. We describe here a case in Pennsylvania, USA, of fatal Versteria infection in a muskrat (Ondatra zibethicus), which, to our knowledge, has not been reported to develop disease associated with infection. Postmortem examination revealed widespread tissue loss and replacement by solid-bodied cestode larvae with minimal adjacent inflammation in many visceral organs, most severe in the lungs, liver, and brain. Key morphologic features via histology included cephalic structures and short rostellar hooklets, which are characteristic for the genus. Genetic characterization confirmed the cestode as being an undescribed lineage of Versteria that has been implicated as the cause of severe morbidity and mortality in humans and nonhuman primates in North America. Considering the zoonotic significance of this pathogen, our report expands on the limited literature regarding disease caused by Versteria and emphasizes the need to identify the causative tapeworm more accurately, especially in rodent intermediate hosts given that previous reports do not have molecular confirmation of species.
A Qualitative Study on Coping Strategies of Chinese Women With Metastatic Breast Cancer Undergoing Chemotherapy

Objectives Women who underwent chemotherapy (CT) for metastatic breast cancer (MBC) used both adaptive and maladaptive coping strategies but had low implementation levels. The present study explores the qualitative experience of coping strategies for women with MBC undergoing CT in Beijing. Methods A hermeneutic phenomenological approach was employed on twenty Chinese MBC women undergoing CT. These interviews were transcribed verbatim, coded using thematic analysis, and analyzed using NVivo 11. Results Three themes are highlighted: Maintaining hope; Spiritual growth, and Self-perceived support resources. Conclusion The present study results have led to a greater understanding of the tremendous impact of CT on MBC women’s lives. This research provides insight into the scope of maintaining hope. Spiritual growth and self-perceived support resources were crucial factors to coping strategies among MBC women to improve their quality of life. Clinical Relevance By attaining the adaptive coping strategies and further understanding about Chinese MBC women, health care professionals are encouraged to appraise MBC women’s specific problems and adopt effective interventions to improve MBC women’s psychosocial wellbeing.
Prognostic Value of Prognostic Nutritional Index in Patients With Colorectal Cancer Undergoing Surgical Treatment

Background To investigate the relationship between prognostic nutritional index (PNI) and the survival of patients with colorectal cancer (CRC) undergoing surgical treatment. Methods In total 1,014 CRC patients who underwent surgical treatment were enrolled. Logistic regression analysis was used to identify the features that influenced postoperative complications in CRC patients. Restricted cubic spline was used to assess the dose-response relationship between PNI and survival in CRC patients. Kaplan-Meier method and log-rank test were used to compare survival differences between groups of CRC patients. Cox proportional risk regression models was used to assess independent risk factors for progression-free survival (PFS) and overall survival (OS) of CRC patients. Results Low PNI was associated with high tumor burden, invasive pathological features, and poor host status. Compared with patients with high PNI, patients with low PNI have a higher incidence of complications and longer hospital stay. Low PNI was an independent risk factor for postoperative complications in CRC patients. for every SD increased in PNI, the risk of poor prognosis for CRC patients was reduced by 2.3% (HR = 0.977, 95%CI = 0.962–0.993, p = 0.004) in PFS, and 2.3% (HR = 0.977, 95%CI = 0.962–0.993, p = 0.004) in OS. PNI was an independent prognostic factor affecting the PFS and OS of CRC patients. Finally, we constructed the PNI-based nomograms to predict postoperative complications, 1–5 years PFS and OS in CRC patients. Concordance index and calibration curve indicated that the PNI-based nomograms have moderate prediction accuracy. Conclusion PNI is an independent risk factor affecting postoperative complications, PFS and OS of CRC patients, and is a useful supplement to the TNM stage.
In moral relationship with nature: Development and interaction

ABSTRACT One of the overarching problems of the world today is that too many people see themselves as dominating other groups of people, and dominating nature. That is a root problem. And thus part of a core solution builds from Kohlberg’s commitment to a universal moral orientation, though extended to include not only all people but the more-than-human world: animals, trees, plants, species, ecosystems, and the land itself. In this article, I make a case for this form of ethical extensionism, and then present psychological evidence for it in both children and adults, including studies with inner-city Black youth and their parents. Then I build on Piaget’s, Kohlberg’s, and Turiel’s emphasis that interaction with the physical and social world is a critical mechanism for development. My corollary is this: that to reverse the incredibly fast human-caused destruction of nature—the wellsprings of human existence—we need to deepen and extend people’s interactions with nature, and with its relatively wild forms, even in urban environments. Toward this end, I discuss my current body of research and framework for urban design based on what are referred to as interaction patterns.
Talking Down Pain in the Prosthesis Clinic: The Emergence of a Local Preference

ABSTRACT Understanding and evaluating pain is a growing concern in clinical practice and health care. In this article we examine how pain is talked about in 24 video-recorded visits of a team of medical professionals with postsurgery amputees. We identify a paradox: Although it is medically useful to identify postamputation pain (it can indicate problematic healing and deter application of a prosthesis), we found that there was a joint preference, by both patients and professionals, to minimize pain sensations. We show how both parties draw on turn design, sequential organization, and multimodal resources to acknowledge some kinds of unpleasant sensations while excluding types of pain that would be problematic in view of the prosthesis. We discuss the importance of the findings in terms of furthering the understanding of situated expression and reporting of pain, the emergence of local preferences in clinical settings, and preference organization in general. Data are in Italian.
The blurred distinction between therapeutic and non-therapeutic medical interventions for intersex children in Australia

ABSTRACT The international community’s response to intersex children’s issues lacks consensus, particularly in the context of medical interventions. Some States prohibit non-consensual genital normalising surgeries, while others encourage this harmful practice. This article employs a human rights lens to analyse and critique Australia’s inaction regarding unnecessary medical interventions on intersex children. It demonstrates that Australia’s current distinction between therapeutic and non-therapeutic medical interventions is underpinned by outdated gender essentialist attitudes, which irrationally characterise variations of sex characteristics as disorders. It examines models of reform adopted internationally to shape recommendations for Australia. This article implores the Australian Government to take legislative action to protect the rights of intersex children, in line with its obligations under international law.
Third Workshop on Building towards Information Interaction and Retrieval Resources Re-use (BIIRRR 2022)

ACM Reference Format: Toine Bogers, Maria Gäde, Mark Hall, Marijn Koolen, Vivien Petras, and Paul Thomas. 2022. ThirdWorkshop on Building towards Information Interaction and Retrieval Resources Re-use (BIIRRR 2022). In Proceedings of the 2022 ACM SIGIR Conference on Human Information Interaction and Retrieval (CHIIR ’22), March 14–18, 2022, Regensburg, Germany. ACM, New York, NY, USA, 3 pages. https://doi.org/10.1145/3498366.3505838
Measurement of Airline Passenger Satisfaction: A Comparison of Methodology

Many methods exist for attempting to quantify passenger satisfaction. Perceptions of satisfaction are typically considered qualitative in nature, which has led to the development of many different methods to represent most holistically the emotions in a quantitative manner. The objective of this analysis centers on attempting to reconcile the differences between the various passenger studies that have been conducted through a review of methodological approaches from such studies. There was a special focus placed upon the differences in results between the response-based Airline Passenger Survey and the Airline Quality Rating, which is compiled using data gathered from airline statistics. Finally, this research led to the identification of manners by which the reviewed studies and methods can be improved to produce more accurate and closely aligned results using an internal purpose-built survey and processing methodology. Airline Passenger Satisfaction Methodology 3
The Crowd is Made of People: Observations from Large-Scale Crowd Labelling

Like many other researchers, at Microsoft Bing we use external “crowd” judges to label results from a search engine—especially, although not exclusively, to obtain relevance labels for offline evaluation in the Cranfield tradition. Crowdsourced labels are relatively cheap, and hence very popular, but are prone to disagreements, spam, and various biases which appear to be unexplained “noise” or “error”. In this paper, we provide examples of problems we have encountered running crowd labelling at large scale and around the globe, for search evaluation in particular. We demonstrate effects due to the time of day and day of week that a label is given; fatigue; anchoring; exposure; left-side bias; task switching; and simple disagreement between judges. Rather than simple “error”, these effects are consistent with well-known physiological and cognitive factors. “The crowd” is not some abstract machinery, but is made of people. Human factors that affect people’s judgement behaviour must be considered when designing research evaluations and in interpreting evaluation metrics.
Reading Between the Lies: A Classification Scheme of Types of Reply to Misinformation in Public Discussion Threads

Online misinformation is a fiendish problem. Demonstrably false information propagates faster and more widely than truth and this has heralded a technological arms race. One possible mechanism for addressing misinformation is social: there is evidence seeing misinformation being challenged can ‘inoculate’ a reader against it. To date, no research has examined how discussions sparked by misinformation play out; What are the different ways in which people reply to posts containing misinformation? How does the discussion flow in each case? Are there differences between platforms? We address these questions through an inductive qualitative analysis of discussion threads on three public discussion platforms (Twitter, YouTube and two news sites) and on three topics (COVID, Brexit and climate change). We present a classification scheme of types of replies to misinformation, and show that replies show different patterns between platforms. Knowing how people reply to posts that contain misinformation enriches our knowledge of ‘human misinformation interaction,’ and provides an understanding of how socio-technical factors in platform design can reduce the risk of misinformation spreading.
Search Interfaces for Biomedical Searching: How do Gaze, User Perception, Search Behaviour and Search Performance Relate?

The objective of this controlled information retrieval (IR) user experiment is to gain an understanding of domain experts’ interactions with novel search interfaces within the context of biomedical information search, with a goal of better search interface design. In this paper, we examine the relationships among user perception, gaze and search behaviour and user search performance. An eye-tracking study of biomedical domain experts’ interactions with novel search interfaces was conducted. A total of thirty-two users participated and searched for documents answering eight complex exploratory search tasks, using four different search interfaces. The findings suggest that gaze behaviour in terms of fixation durations based measures of areas of interest (AOI), i.e., visual attention to the elements of title, author, abstract and MeSH (Medical Subject Headings) terms in document surrogates is correlated with search performance. Users are more likely to achieve better search performance by precision-based measures when 1) search tasks are perceived as difficult; 2) users attend to the element of abstract; and 3) users can recall using the per-query suggestions during the search processes. More importantly, our findings suggest that a user search interface design that displays contextual information between the suggested keywords and the document may better support users reformulating their queries for complex search tasks in the biomedical domain. We discuss implications for the design of search user interfaces for biomedical searching.
Taxonomy of Routing Protocols

IoT has gained popularity in the networking as well as in day to day life such as smart watches, computers, smart phones, smart electronic devices. IoT is generally for providing a communication infrastructure between two ends having various issues such as availability, mobility, performance, data security, congestion control, load balancing. In this paper, detailed discussion about IoT routing protocols that are directly or indirectly using in the IoT environment. This review paper studies different routing protocols based on networking layer, network structure based(flat, hierarchical, location), path/route discovery based routing protocols has sensibly reviewed in detail on basis of various parameters, the advantages and the difference between them. Finally, in the last of research we identified different routing issues and challenges which need to be addressed in the coming future scope. This study focuses on data routing in the IoT. The aim is to not only interpret, correlate, and summarize previous research, but also to understand and examine their results in relation to the Internet of Things.
E. coli Leucine-responsive regulatory protein bridges DNA in vivo and tunably dissociates in the presence of exogenous leucine

Feast-Famine Response Proteins are a widely conserved class of global regulators in prokaryotes, the most highly studied of which is the E. coli leucine-responsive regulatory protein (Lrp). Lrp senses environmental nutrition status and subsequently regulates up to one-third of the genes in E. coli, either directly or indirectly. Lrp exists predominantly as octamers and hexadecamers (16mers), where leucine is believed to shift the equilibrium towards the octameric state. In this study, we analyzed the effects of three oligomerization state mutants of Lrp in terms of their ability to bind to DNA and regulate gene expression in response to exogenous leucine. We find that oligomerization beyond dimers is required for Lrp’s regulatory activity, and that contrary to prior speculation, exogenous leucine modulates Lrp activity at its target promoters exclusively by inhibiting Lrp binding to DNA. We also find evidence that Lrp binding bridges DNA over length scales of multiple kilobases, revealing a new range of mechanisms for Lrp-mediated transcriptional regulation.
Bayesian multi-model-based 13C15N-metabolic flux analysis quantifies carbon-nitrogen metabolism in mycobacteria

Metabolic flux is the final output of cellular regulation and has been extensively studied for carbon but much less is known about nitrogen, which is another important building block for living organisms. For the pathogen Mycobacterium tuberculosis (Mtb), this is particularly important in informing the development of effective drugs targeting Mtb’s metabolism. Here we performed 13C15N dual isotopic labelling of mycobacterial steady state cultures and quantified intracellular carbon-nitrogen (CN) and nitrogen (N) fluxes in addition to carbon (C) fluxes and inferred their reaction bidirectionalities. The combination of 13C15N-MFA with a Bayesian multi-model approach allowed us to resolve C and N fluxes simultaneously which was not possible with classical 13C-MFA. We quantified CN fluxes for amino acid and, for the first time, nucleotide biosynthesis. Our analysis identified glutamate as the central CN and N node in mycobacteria, and improved resolution of the anaplerotic node. Our study describes a powerful platform to measure carbon and nitrogen metabolism in any biological system with statistical rigor.