Miracle-dz/UniFAR-FTUs huggingface dataset:
PGPM_A_233485 227..238

1Oncology Department, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 2Department of Surgery, Tel Aviv-Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Abstract: Hereditary breast cancer syndromes affect a small (10–15% of cases) but significant group of patients. BRCA1 and BRCA2 are the most familiar and well-studied genes associated with inherited breast cancer. However, mutations in the high-penetrance genes, TP53, PTEN, CDH1, MSH1, MLH1, MSH6, PMS2, PALB2, and STK11, and in the moderate-penetrance genes, CHEK2, ATM, and BRIP1, also correlate with high lifetime risks of breast cancer and other malignancies as well. Advances in breast cancer genetics have led to an improved perception of diagnosis and screening strategies. The specific considerations and challenges involved in treating this unique population have become a fertile ground for research. Indeed, these genes and downstream molecular pathways have now become potential therapeutic targets in breast cancer patients, including those with BRCA1 or BRCA2 mutations. This review describes the variety of hereditary breast cancer genes, from their molecular origins to the prognosis and multidisciplinary clinical decisionmaking processes. Key publications and other reported recent clinical trials and guidelines are provided.
Stochastic Resonance: From Suprathreshold Stochastic Resonance to Stochastic Signal Quantization

Preface 1. Introduction and motivation 2. Stochastic resonance: its definitions, history and debates 3. Stochastic quantization 4. Suprathreshold stochastic resonance: encoding 5. Suprathreshold stochastic resonance: large N encoding 6. Suprathreshold stochastic resonance: decoding 7. Suprathreshold stochastic resonance: large N decoding 8. Optimal stochastic quantization 9. SSR, neural coding, and performance tradeoffs 10. Stochastic resonance in the auditory system 11. The future of stochastic resonance and suprathreshold stochastic resonance Appendices References Index.
Interrelationships between Infliximab and rhTNF- α in Plasma using Minimal Physiologically-Based Pharmacokinetic (mPBPK) Models

The soluble cytokine TNF- α is an important target for many therapeutic proteins used in the treatment of rheumatoid arthritis (RA). Biologics targeting TNF- α exert their pharmacological effects through binding and neutralizing this cytokine and preventing it from binding to its cell surface receptors. The magnitude of their pharmacological effects directly corresponds to the extent and duration of free TNF- α suppression. However, endogenous TNF- α is of low abundance and therefore it is quite challenging to assess the free TNF- α suppression experimentally. Here we have applied an experimental approach to bypass this difficulty by giving rhTNF- α to rats by SC infusion. This boosted TNF- α concentration enabled quantification of TNF- α in plasma. Free rhTNF- α concentrations were measured after separation from the infliximab-rhTNF- α complex using Dynabeads Protein A. The interrelationship of infliximab and TNF- α was assessed with minimal physiologically-based pharmacokinetic (mPBPK) models for TNF- α and infliximab with a target-mediated drug disposition (TMDD) component. Knowledge of TNF- α PK allows reliable prediction of the free TNF- α suppression with either free or total TNF- α concentration profiles. The experimental and modeling approaches in the present study may aid in the development of next-generation TNF- α inhibitors with improved therapeutic effects.
¿Son las fincas agroecológicas resilientes? Algunos resultados utilizando la herramienta SHARP-FAO en Costa Rica

Considerando la actual variabilidad del clima, cada vez se requiere con mas urgencia medir y monitorear la resiliencia climatica para informar y empoderar a los pequenos productores agrosilvopastoriles. Aunque existen otras formas de medir la resiliencia, la novedosa herramienta SHARP desarrollada por la FAO permite la identificacion, medicion y priorizacion de acciones para mejorar la resiliencia climatica de una manera participativa, tomando en cuenta los intereses de los productores. En coordinacion con el equipo desarrollador de la aplicacion de la FAO en Roma, se tradujeron y utilizaron el cuestionario y la matriz para la evaluacion de la resiliencia en 16 fincas agroecologicas situadas en los alrededores del Valle Central de Costa Rica. Una vez colectados e ingresados los datos en SHARP, se llevaron a cabo tres analisis: 1) comparacion del perfil de las fincas estudiadas con indicadores a nivel nacional; 2) analisis de brechas para identificar las oportunidades de mejora en terminos de resiliencia climatica; 3) un analisis para adaptar la herramienta al contexto nacional. A pesar de que las fincas seleccionadas para el estudio son reconocidas como agroecologicas, su nivel medio de resiliencia sugiere la necesidad de implementar practicas de manejo que contribuyan con la construccion de agroecosistemas mas resilientes.
LYMPHOID NEOPLASIA Both mature KIR 1 and immature KIR 2 NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdc scid IL2rg tmWjl /Sz mice

appears to be resistant to NK-cell–mediated lysis, recentdataindicatethatpediatricBCP-ALLmightyetbeatargetofNKcells.Inthisstudy,we demonstrate in a donor-patient–specific NOD.Cg- Prkdc scid IL2rg tmWjl /Sz (NSG) xenotransplantation model that NK cells mediate considerable alloreactivity toward pediatric BCP-ALL in vivo. Notably, both adoptively transferred mature KIR 1 NK cells and immature KIR 2 NK cells arising early posttransplantation in humanized NSG mice exerted substantial antileukemicactivity.Low-doseandlong-termtreatmentofhumanizedNSGmicewiththe DNA-demethylating agent 5-aza-cytidine distinctly enhanced the antitumor response, interestinglywithoutinducingcommoninhibitoryKIRexpressionbutratherbypromoting the differentiation of various NK-cell precursor subsets. Collectively, these data indicate that the future design of innovative therapy protocols should consider further exploitation of NK-cell–mediated immune responses for poor prognosis pediatric BCP-ALL patients. ( Blood . 2014;124(26):3914-3923) Beckman Coulter), and KIR2DL1/ S1/S4 (HP-3E4; BD Pharmingen). The selective combination of anti-KIRmAbs withdifferentoridentical ﬂ uorochromesherebyallowedthediscriminationof KIR 2 , nonalloreactive or alloreactive KIR 1 NK-cell subsets in the context of Bw4/C1 target cell recognition. Methods concerning ﬂ ow-cytometric analyses, determination of in vitro cytotoxicity, and KIR quantitative polymerase chain reaction are referred to in supplemental “ Materials and methods. de ﬁ ning the speci ﬁ city and clonal distribution of “ alloreactive ” NK cells. 2 Collectively, these 2 preliminary studies show that the incor-porationoftheoreticalassumptionsonKIR-KIRLinteractionsinhaplo-identicalHSCTsofchildrenwithBCP-ALLisfeasible,thatsuchamodeofdonorselectiondoesnotheightentheriskofgraft-versus-hostdisease,andthattheanalysisofreceptor-ligandconstellationsmayhave prognostic implications.
OPTO_A_250813 183..187

1Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran; 2Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran; 3Rehabilitation Research Center, Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran; 4Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 5Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Purpose: The aim of this study is to evaluate the effect of active vision therapy in adults with anisometropic amblyopia. Methods: In this study, 20 adults with anisometropic amblyopia aged from 17–35 years old were treated for five sessions (one session per week) with vision therapy techniques which include accommodative rock, vergence rock, and saccadic training. Moreover, computerized vision therapy was performed by Optosys software. Also, patients had been given a daily program for home training, including accommodative and vergence rock, and Optosys software. Best corrected visual acuity (BCVA) was measured before and after treatment. Results: Comparison of data using t-test showed that BCVA significantly improved after the vision therapy period. Initial BCVA (Log MAR) was 0.37±0.04 (mean±standard deviation) which improved to 0.14±0.03 after treatment. The correlation between initial BCVA and the amount of improvement showed that the worse the pre-treatment visual acuity was, the greater improvement that occurred. Conclusion: The improvement of visual acuity in adult anisometropic amblyopes showed that there are some degrees of plasticity in the visual system of amblyopic patients even in adulthood. Thus, therapists should give the chance of treatment to adult amblyopes.
Do Oil Industry Merger Waves Reveal Any Trends?

The dynamics of the stock prices of oil industry acquirer companies are studied during in-wave and out-wave years between 1998 and 2013. The research question is do oil industry merger waves reveal any trends? This quantitative study focuses on stock returns of acquirer companies over a 4-year horizon for each merger transaction. Portfolios created from these transactions provide a comparison between in-wave and out-wave years. Three benchmarks are incorporated to provide various economic adjustment factors. Six cases are presented whose outcome largely follow other similar studies. The main contribution of the study is the identification of a dynamic during oil industry in-wave years which sees a substantial increase in the Brent oil market price, of at least 29% for these in-wave years. This dynamic is not identified previously in the literature.
WIDER Working Paper 2020/170 Special economic zones and transnational zones as tools for Southern Africa’s growth best practice

: The paper evaluates strategies for developing successful special economic zones and transnational zones for Southern African countries to spur growth and employment. Most special economic zones implemented in Southern Africa have largely failed to bring adequate growth and employment due to numerous constraints. Globally, selected countries have successfully implemented export-oriented industries through such spatial industrial policy. We review case studies across the world by comparing different regions on selected indicators related to the best-practice framework developed through this study. The framework represents the five key components of successful special enterprise zones, namely: institutional arrangements; running (operational) reflection/review mechanisms. We identify best practice and review the implications for implementation and sustainability strategy in Southern Africa. The main findings point to unique lessons from international best practice on the establishment and operational strategy for zones and opportunities for transnational zones.
DMSO_A_338728 4505..4512

1Center of Clinical Epidemiology, TEDA International Cardiovascular Hospital, Tianjin, People’s Republic of China; 2Department of Pediatrics, Center Hospital of Beikuo Town, Rizhao City, Shandong Province, People’s Republic of China; 3Department of Disease Prevention and Control, Hospital of Gaoxing Town, Rizhao City, Shandong Province, People’s Republic of China; 4Department of Hypertension, TEDA International Cardiovascular Hospital, Tianjin, People’s Republic of China
Competence Need Fulfillment Increases Engagement: Does Individual Need Strength Moderate the Effect?

The empirical literature on Self Determination Theory is unclear about whether individual need strength moderates and enhances the effect of basic need fulfillment on positive outcome variables. This study tested whether competence need strength moderates the effect of competence need fulfillment on engagement. A sample of 181 students was randomly assigned into three experimental conditions and their felt competence was manipulated. Results showed that the high need fulfillment group had significantly higher engagement levels than the low need fulfillment group. However, there was no evidence for a moderation effect of need strength on the relation between need fulfillment and engagement.
Integrated Therapy: Dedicated Training and Edicated Training and Proposed Patterns

This study is a review of both the extensive literature on integrated mental health therapy and the author's clinical and training experience in this field. The study wants to emphasize the need for training dedicated to the themes of therapeutic integration, the importance of some basic principles for making an integrative network and the mental attitude that professionals must acquire to correctly deal with the work involved in integrated therapy. Those working in psychiatry, psychotherapy, and other mental health fields will be increasingly interested in integrated therapeutic processes in the future.
Existence of entire solutions to a fractional Liouville equation in R n

We study the existence of solutions to the problem where Q = ( n − 1)! or Q = − ( n − 1)! Extending the works of Wei-Ye and Hyder-Martinazzi to arbitrary odd dimension n ≥ 3 we show that to a certain extent the asymptotic behavior of u and the constant V can be prescribed simultaneously. Furthermore if Q = − ( n − 1)! then V can be chosen to be any positive number. This is in contrast to the case n = 3, Q = 2, where Jin-Maalaoui-Martinazzi-Xiong showed that necessarily V ≤ | S 3 | and to the case n = 4, Q = 6, where C-S. Lin showed that V ≤ | S 4 |
Evaluation of two protocols developed for Xanthomonas albilineas molecular detection in sugarcane

Leaf scald disease caused by Xanthomonas albilineans (Ashby) Dowson is one of the most devastating diseases of sugarcane which has a direct impact on production and manufacturing quality. Currently, molecular tests have been proposed for the detection of this phytopathogen. In this work, two PCR's protocols developed by Pan et al. in 1997 and 1999 were evaluated, with primers that amplify a fragment of the ITS region between the ribosomal genes 16S and 23S. The search of X. albilineans was done from the juice obtained of 35 asymptomatic and symptomatic plants of sugarcane cultivated in localities of the provinces of Misiones and Corrientes, Argentina. X. albilineans was detected in only one of the symptomatic samples but in any of the asymptomatic ones. The protocol developed in 1999 was the one that gave the best results. It is important to emphasize the detection of this phytopathogen in the province of Misiones.
The Acute E ﬀ ect of Match-Play on Hip Isometric Strength and Flexibility in Female Field Hockey Players

: The aim of this study was to determine the acute e ﬀ ect of simulated ﬁeld hockey match-play on isometric knee ﬂexion, adductor (ADD) and abductor (ABD) strength, adductor / abductor (ADD / ABD) strength ratio, countermovement jump height (CMJ), hip ﬂexion and ankle dorsiﬂexion range of motion (ROM). Thirty competitive female ﬁeld hockey players (23.0 ± 3.9 years old) participated in the study. Apart from the afore-mentioned variables, external (through GPS) and internal load (through RPE) were measured before (pre-match) and immediately after simulated hockey match-play (post-match) in both limbs. Isometric knee ﬂexion strength ( + 7.0%, p = 0.047) and hip ﬂexion ROM ( + 4.4%, p = 0.022) were higher post-match in the non-dominant limb, while CMJ values reduced ( − 11.33%, p = 0.008) when comparing from pre-match data. In addition, no di ﬀ erences were observed for isometric hip ADD, ABD, ADD / ABD strength ratio, passive hip ﬂexion ROM and ankle dorsiﬂexion ROM test. A simulated ﬁeld-hockey match produces an increment in hip isometric strength and hip ﬂexion ROM values in the non-dominant limb and a decrease in jump height capacity. As a result, CMJ assessment should be considered post-match in order to identify players who would require further rest before returning to training.
This information is current as Regulator of the IFN Responses in Fish IFN Regulatory Factor 10 Is a Negative

IFN regulatory factor (IRF) 10 belongs to the IRF family and exists exclusively in birds and fish. Most IRFs have been identified as critical regulators in the IFN responses in both fish and mammals; however, the role of IRF10 is unclear. In this study, we identified IRF10 in zebrafish (Danio rerio) and found that it serves as a negative regulator to balance the innate antiviral immune responses. Zebrafish IRF10 (DrIRF10) was induced by intracellular polyinosinic:polycytidylic acid in ZF4 (zebrafish embryo fibroblast-like) cells. DrIRF10 inhibited the activation of zebrafish IFN1 (DrIFN1) and DrIFN3 promoters in epithelioma pap-ulosum cyprinid cells in the presence or absence of polyinosinic:polycytidylic acid stimulation through direct interaction with the IFN promoters, and this inhibition was also shown to block IFN signaling. Overexpression of DrIRF10 was able to abolish the induction of DrIFN1 and DrIFN3 mediated by the retinoic acid–inducible gene I–like receptors. In addition, functional domain analysis of DrIRF10 showed that either the DNA binding domain or the IRF association domain is sufficient for its inhibitory activity for IFN signaling. Lastly, overexpression of DrIRF10 decreased the transcription level of several IFN-stimulated genes, resulting in the susceptibility of host cells to spring viremia of carp virus infection. Collectively, these data suggest that DrIRF10 inhibits the expression of DrIFN1 and DrIFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates. I nterferon responses are considered as the first line in the process of host defense against virus infection (1). Through the pattern recognition receptors, host cells recognize the viral components and activate downstream signaling proteins to initiate the transcription of IFN and IFN-stimulated genes (ISGs) (2). Among the pattern recognition receptors, retinoic acid–in-ducible gene I (RIG-I)–like receptors (RLRs), involved in the recognition of cytosolic viral RNA, comprise three members: RIG-I, melanoma differentiation-associated gene 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2). RIG-I and MDA5 bind to viral RNAs through their C-terminal regulatory domain and transduce the signals to downstream adaptor mito-chondrial antiviral signaling protein via their two N-terminal tandem caspase recruitment domains. This leads to the recruitment of TANK-binding kinase 1 (TBK1) to activate IFN regulatory factors (IRFs) 3 and 7, which, in turn, cooperatively initiate the expression of type I IFNs. The signal transduction between mitochondrial antiviral signaling protein and TBK1 is mediated by mediator of IRF3 activation (MITA). However, LGP2, lacking the two caspase recruitment domains in …
E V ects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p (cid:2) -DDT in U937 macrophages

To assess the e V ectiveness of selected food phytochemicals in reducing the toxic e V ects of the environmental toxicants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and p,p (cid:2) -DDT (DDT), we tested the potencies of auraptene, nobiletin, zerumbone, and ( § )-13-hydroxy-10-oxo-trans-11-octadecenoic acid (13-HOA) in reversing the in X ammatory action of these toxicants in U937 human macrophages. Using quantitative RT–PCR as the initial screening assay, we identi W ed antagonistic actions of zerumbone and auraptene against the action of TCDD and DDT in up-regulating the mRNA expressions of COX-2 and VEGF. The functional signi W cance of the inhibitory action of zerumbone on COX-2 expression was con W rmed by demonstrating its suppression of TCDD-induced activation of COX-2 gene expression in mouse MMDD1 cells. We tested auraptene on DDT-induced reactive oxygen species (ROS) formation in U937 macrophages and found that auraptene is a powerful agent antagonizing this action of DDT. To con W rm the signi W cance of these actions of zerumbone and auraptene at the cellular level, we assessed their in X uence on TCDD-induced apoptosis resistance in intact U937 macrophages and found that they are capable of reversing this action of TCDD. In conclusion, zerumbone and auraptene were identi W ed to be the most e V ective agents in protecting U937 macrophages from developing these cell toxic e V ects of TCDD and DDT.
Inﬂuence of the P´eclet number on reactive viscous ﬁngering

The hydrodynamic viscous ﬁngering instability can be inﬂuenced by a simple viscosity changing chemical reaction of type A + B → C , when a solution of reactant A is injected into a solution of B and a product C of diﬀerent viscosity is formed by reaction. We investigate here numerically such reactive viscous ﬁngering in the case of a reaction decreasing the viscosity to deﬁne the optimal conditions on the chemical and hydrodynamic parameters for controlling ﬁngering. In particular, we analyze the inﬂuence of the P´eclet number Pe on the eﬃciency of the chemical control of ﬁngering. We show that the viscosity decreasing reaction has an increased stabilizing eﬀect when Pe is decreased. On the contrary, ﬁngering is more intense and the system more unstable when Pe is increased. The related reactive ﬁngering patterns cover then respectively a smaller (larger) area than in the non-reactive equivalent. Depending on the value of the P´eclet number, a given chemical reaction may thus either enhance or suppress a ﬁngering instability. This stabilization and destabilization at low and high Pe are shown to be related to the Pe-dependent characteristics of a minimum in the viscosity proﬁle that develops around the miscible interface thanks to the eﬀect of the chemical reaction.
Retraction of general relativistic shock wave interaction are ‘regularity singularities’ where space–time is not locally flat

With apologies, we must inform the reader that the result announced in our RSPA publication [1] is false. Although the issues and motivations regarding the problem as to whether regularity singularities exist at points of shock wave interaction in GR set out in Reintjes & Temple [1] are valid, there is a flaw in the final chapter of our proof that cannot be fixed. In trying to fix the flaw, we have discovered that the strategy can be used to prove the opposite statement: a C0,1 metric of a shock wave solution of the Einstein equations can always be smoothed to C1,1 by a coordinate transformation in a neighbourhood of a point of shock wave interaction between shocks from different characteristic families, in spherical symmetry. The precise statement of the result with detailed proofs is recorded in Reintjes [2]. This new result contradicts our incorrect claim in Reintjes & Temple [1] that regularity singularities are created by spherically symmetric shock wave interactions. However, the larger question as to whether regularity singularities exist in more complicated shock wave solutions of the Einstein–Euler equations remains an open problem. Thus, the larger issues laid out in Reintjes & Temple [1] remain valid. We now identify the mistake in Reintjes & Temple [1]. To start, all of the mathematics in section 2–6 of Reintjes & Temple [1] remains correct without change. The mistake is in the last section, and this propagates into a mistake in the proof of the main theorem. Specifically, our proof in Reintjes & Temple [1] is based on the violation of the identity (7.9), which according to the argument there, is required for the smoothing coordinates to exist. But, this violation was due to the error of neglected terms that should have been present in our ansatz for the Jacobians in (7.1) of lemma 7.2 in Reintjes & Temple [1], the ansatz that meets what we refer to as the smoothing condition (c.f. (5.3) in Reintjes & Temple [1]). The missing terms in the expression for the Jacobians in (7.1) are the source of the error in Reintjes & Temple [1], because this Jacobian ansatz fails to meet the smoothing conditions.