Miracle-dz/UniFAR-FTUs huggingface dataset:
Economic hardship and well-being

With the aftermath of the economic crisis starting to fold out, the extent and the conditions under which the experience of economic hardship thwarts subjective well-being spark academic interest. In this paper, we examine the cushioning impact of three immaterial buffers embedded within civil society—namely social networks, religiosity, and conﬁdence in politics—in combination with the cushioning role of the welfare state. Analyzing the 2010 wave of the European Social Survey, the results conﬁrm that the experience of economic hardship is inversely related to happiness. All three proposed protective measures cushion the negative impact of economic strain on happiness, whereby the positive effect of social networks and conﬁdence in politics is stronger in countries with lower levels of social expenditure. The latter ﬁnding provides some evidence for the crowding out-thesis but mainly suggests that a strong welfare state can take over the role of protective buffers in civil society, which is helpful as such buffers are less present among the most vulnerable social groups. The results of the analysis are discussed in relation to social science research and public policy.
The diﬀeomorphism type of symplectic ﬁllings

We show that simply connected contact manifolds that are subcritically Stein ﬁllable have a unique symplectically aspherical ﬁlling up to diﬀeomorphism. Various extensions to manifolds with non-trivial fundamental group are discussed. The proof rests on homological restrictions on symplectic ﬁllings derived from a degree-theoretic analysis of the evaluation map on a suitable moduli space of holomorphic spheres. Applications of this homological result include a proof that compositions of right-handed Dehn twists on Liouville domains are of inﬁnite order in the symplectomorphism group. We also derive uniqueness results for subcritical Stein ﬁllings up to homotopy equivalence and, under some topological assumptions on the contact manifold, up to diﬀeomorphism or symplectomorphism.
SAW Based Phononic Crystal Liquid Sensor with Integrated Periodic Microfluidic Channels

— Phononic crystal sensors that have been developed in the last years proof being a promising sensor platform for different applications as liquid sensors. It has been already shown that the transmission spectrum of phononic structures depends on properties of liquids confined within a crystal. In comparison to known established sensor approaches, where sensors respond to near surface effects such as mass load, the distinguishing feature of proposed solutions is confining the liquid in resonant cavities of the phononic structure allowing determination of volumetric (bulk) properties of the liquid. Current contribution presents technological and experimental results of the surface acoustic wave (SAW) based phononic crystal liquid sensor research. The presented sensor concept integrates an array of periodical microfluidic channels into the SAW platform. Theoretical predictions underline strong demands regarding tolerances of phononic structure dimensions. As a result, the technological process of the sensor manufacturing had to be redesigned in a certain manner. Achieved results, technological challenges and solutions are described in current work.
OPTH_A_281860 3821..3828

1Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 2Department of Ophthalmology, Faculty of Medicine, Minia University, Minia, Egypt Purpose: To describe the clinical profile of patients with HLA-B27-associated uveitis at 2 Egyptian tertiary eye centers. Methods: A retrospective study reviewing the medical records of all patients with HLAB27-associated uveitis served at 2 uveitis referral clinics in Egypt between January 2010 and June 2018. Results: The study included a total of 554 patients. Anterior uveitis was the most common type. Ankylosing spondylitis was an important systemic comorbidity in the present study, affecting 27.4% of our patients. Cataract was the most frequent ocular complication. By the conclusion of the study, 6.1% of the affected eyes had a BSCVA poorer than 20/200. Conclusion: The clinical profile of HLA-B27-associated uveitis in our cohort of Egyptian patients is similar to that reported from other regions of the world. In our study, a relatively high rate of cataract was observed.
Jupiter gravity ﬁ eld estimated from the ﬁ rst two Juno orbits

The combination of the Doppler data from the ﬁ rst two Juno science orbits provides an improved estimate of the gravity ﬁ eld of Jupiter, crucial for interior modeling of giant planets. The low ‐ degree spherical harmonic coef ﬁ cients, especially J 4 and J 6 , are determined with accuracies better than previously published by a factor of 5 or more. In addition, the independent estimates of the Jovian gravity ﬁ eld, obtained by the orbits separately, agree within uncertainties, pointing to a good stability of the solution. The degree 2 sectoral and tesseral coef ﬁ cients, C 2,1 , S 2,1 , C 2,2 , and S 2,2 , were determined to be statistically zero as expected for a ﬂ uid planet in equilibrium.
Inheritance and the extensive margin of fertility * Short title : Childless Aristocrats

Using genealogical data of British aristocrats, we show that inheritances can affect childlessness. We study settlements, a contract restricting heirs’ powers and settling bequests for yet-to-be-born generations. Settlements reduced childlessness to the “natural” rate, ensuring aristocratic dynasties’ survival. Our estimation exploits that settlements were signed at the heir’s wedding if the family head lived until this date. Whether the heir was born after a girl provides as-good-as-random assignment into settlements. Next, we develop a theory that reproduces our findings, shows that exponential discounting cannot rationalize inheritance systems restricting heirs, and that inheritance systems can emerge endogenously when fertility concerns exist. JEL classification: J13, K36, N33.
Title: The Impact of Authoritarian Leadership on Ethical Voice: A Moderated Mediation Model of Felt Uncertainty and Leader Benevolence Running head: The Impact of Authoritarian Leadership on Ethical Voice

In a sample of 522 police officers and staff in an English police force, we investigated the role of authoritarian leadership in reducing the levels of employee ethical voice (i.e. employees discussing and speaking out opinions against unethical issues in the workplace). Drawing upon uncertainty management theory, we found that authoritarian leadership was negatively related to employee ethical voice through increased levels of felt uncertainty, when the effects of a motivational-based mechanism suggested by previous studies were controlled. In addition, we found that the negative relationship between authoritarian leadership and employee ethical voice via felt uncertainty is mitigated by high er levels of benevolent leadership. That is, when authoritarian leaders simultaneously exhibit benevolence, they are less likely to cause feelings of uncertainty in their followers who are then more likely to speak up about unethical issues. We discuss theoretical and practical implications of the findings.
(cid:1) -Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction

(cid:1) -Adrenergic receptor (AR) blockers provide substantial clinical beneﬁts, including improving overall survival and left ventricular (LV) function following myocardial infarction (MI), though the mechanisms remain incompletely deﬁned. The transverse-tubule (T-tubule) system of ventricular myocytes is an important determinant of cardiac excitation-contraction function. T-tubule remodeling occurs early during LV failure. We hypothesized that (cid:1) -AR blockers prevent T-tubule remodeling and thereby provide therapeutic beneﬁts. A murine model of MI was utilized to examine the effect of (cid:1) -AR blockers on T-tubule remodeling following LV MI. We applied the in situ imaging of T-tubule structure from Langendorff-perfused intact hearts with laser scanning confocal microscopy. We found that MI caused remark-able T-tubule remodeling near the infarction border zone and moderate LV remodeling remote from the MI. Metoprolol and carvedilol administered 6 d after MI for 4 wk each increased the T-tubule integrity at the remote and border zones. At the molecular level, both (cid:1) -AR blockers restored border and remote zone expression of juncto-philin-2 (JP-2), which is involved in T-tubule organization and formation of the T-tubule/sarcoplasmic reticulum junctions. In contrast, (cid:1) -AR blockers had no signiﬁcant effects on caveolin-3 expression. In summary, our data show that (cid:1) -AR antagonists can protect against T-tubule remodeling after MI, suggesting a novel therapeutic mechanism of action for this drug class. Preservation of JP-2 expression may contribute to the beneﬁcial effects of metoprolol and carvedilol on T-tubule remodeling. —
PULMONARY TUBERCULOSIS IN DIABETES MELLITUS IN DIABETIC PATIENTS

: Background: The study of diabetic patients, their clinical profile of pulmonary tuberculosis and radiographic patterns of pulmonary tuberculosis in diabetic patients. Methods: The study included 100 patients that had diabetes mellitus and pulmonary tuberculosis. The range included of both genders who have been admitted to Services Hospital Lahore. Results: The patients underwent the blood sugar test and the fasting blood sugar value showed definite co-relation with pulmonary tuberculosis. The patients who had fasting blood sugar value between 201 to 300mg/dl were 41% and value between 151-200mg/dl 30% and the remaining 23% of the patients had this value above 300mg/dl. Mean fasting blood sugar value was 234.4mg/dl. Lung lesions were noted in 37% of the cases on right side and left sided lesions were found in 33% of the cases. Upper lobe lesions were noted in 68% and bilateral lesions in 30% of the cases. Conclusions: Diabetes mellitus when uncontrolled, patients are more prone to develop pulmonary tuberculosis compared to non-diabetics. Sputum examination most of times shows to be positive in diabetics as compared to non-diabetics.
Thickness-dependent electronic structure of ultrathin SrRuO3 films studied by in situ photoemission spectroscopy

In situ thickness-dependent photoemission spectroscopy (PES) has been performed on SrRuO3 (SRO) layers deposited on SrTiO3 substrates to study the structure-induced evolution of the electronic structure. The PES spectra showing the existence of two critical film thicknesses reveal that a metal-insulator transition occurs at a film thickness of 4–5 monolayers (ML) and the evolution of Ru 4d-derived states around the Fermi level (EF) saturates at about 15 ML. The observed spectral behavior well matches the electric and magnetic properties and thickness-dependent evolution of surface morphology of the ultrathin SRO films. These experimental results suggest the importance of the disorder associated with the unique growth-mode transition in SRO films.
COPD_A_311236 2119..2127

1Department of Respiratory Medicine, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 2Department of Respiratory Medicine, Zealand University Hospital Næstved, Næstved, Denmark; 3Institute of Regional Health Research, University Southern Denmark, Odense, Denmark; 4Department of Respiratory Medicine, North Zealand Hospital, Hillerød, Denmark; 5Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Background and Objective: Prescribing inhaled corticosteroids (ICS) for bronchiectasis (BE) in the absence of obstructive lung disease is controversial. Studies investigating ICS therapy and impact on morbidity and mortality in BE are sparse. Methods: This study comprises all patients with BE managed at respiratory outpatient clinics at two university hospitals in the Capital Region of Denmark 2014–2015. Baseline data were obtained from patient medical records, and patients were followed until April 2020. Results: Out of 264 patients, 122 (46%) were prescribed ICS with no demographic differences between users/non-users of ICS. Among patients prescribed ICS, 21% did not have a concomitant diagnosis of asthma or COPD. Patients prescribed ICS had lower lung function (median FEV1 65.2 vs 80.9%pred, p<0.001) and a higher symptom burden in terms of cough (p 0.028), sputum production (p <0.001) and dyspnea (p <0.001). Pseudomonaspositive sputum cultures were more common in ICS-treated patients (6.5 vs 20%, p 0.010), as were previous severe exacerbations (41% vs 21%, p <0.001). In terms of mortality, highdose ICS use was associated with increased mortality in multivariable Cox regression adjusted for age, sex, FEV1 and concomitant asthma/COPD (HR 4.93 [95% CI 1.73–14.0], p 0.003). Conclusion: In this cohort, close to one out of five patients with BE were prescribed ICS despite having no concomitant diagnosis of asthma or COPD. Overall, ICS treatment was associated with higher morbidity and mortality, though causation is difficult to establish.
COVID-19 and E-Learning: Nigeria Tertiary Education System Experience

- Globally, the world is faced with the COVID-19 pandemic which has held the economy at ransom not exempting the educational sector. This pandemic has brought about recent changes and disruptions in the educational sector which serves as a catalyst for the development of any nation. Educational sector globally is seen to be shifting towards e-learning in order to cushion the effect of this pandemic. However, developing countries evidence from the Nigeria experience are posed with the challenge of shifting from the traditional teaching method to the e-learning during the pandemic. The challenges arise as a result of the varying degree of preparedness of the institutions, lack of infrastructures, paucity of funds and policies issues in the Nigeria education sector. It is in tandem with this prevailing issues that this study examines the Nigeria educational system based on the global pandemic. This paper further discusses the necessity of e-learning; identifies and discuss challenges as well as opportunities. Recommendations to enhance e-learning during and post COVID-19 were also given.
CMAR_A_255552 4911..4921

1Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara-City, Kanagawa 252-0374, Japan; 2Kitasato University School of Nursing, Sagamihara-City, Kanagawa 2520329, Japan; 3School of Allied Health Sciences, Kitasato University, SagamiharaCity, Kanagawa 252-0373, Japan; 4Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara-City, Kanagawa 252-0374, Japan Purpose: Amrubicin (AMR) is an anticancer drug for patients with relapsed small-cell lung cancer (SCLC). However, the efficacy of AMR in elderly patients with relapsed SCLC after chemotherapy by carboplatin plus etoposide (CE) has not been sufficiently evaluated. Patients and Methods: The medical records of patients with relapsed SCLC who received AMR as second-line chemotherapy were retrospectively reviewed, and their treatment outcomes were evaluated. Results: Forty-one patients with a median age of 76 years were analyzed. The overall response rate was 26.8%. Median progression-free survival (PFS) and overall survival (OS) were 3.5 and 8.1 months, respectively. While the median PFS of 4.7 and 2.8 months in the sensitive relapse and the refractory relapse group differed significantly (P=0.043), respectively, the median OS of 10.7 and 6.8 months in the respective relapse groups did not indicate a statistically significant difference (P=0.24). The median PFS in a group with a modified Glasgow prognostic score (mGPS) of 0 and a group with a mGPS 1 or 2 were 4.5 and 1.6 months (P=0.052), respectively, and the median OS in the respective mGPS groups were 10.7 and 4.4 months (P=0.034). Multivariate analysis identified good performance status, limited disease, and mGPS 0 as favorable independent predictors of PFS and OS of AMR monotherapy. Grade 3 or higher neutropenia was observed in 23 patients (56%), and febrile neutropenia was observed in nine patients (22%). Non-hematological toxic effects were relatively mild, and pneumonitis and treatment-related deaths were not observed. Conclusion: AMR is an effective and feasible regimen for elderly patients with relapsed SCLC after CE therapy.
Prevalence, Risk Factors and Prevention of Depression in the Adult Population in Mbarara District, Uganda

Background. This study concerns the prevalence, risk factors and prevention of depression in the adult population in three sub-counties in Mbarara district. Depression is a common mental disorder which presents with a wide array of symptoms including loss of energy, poor sleep, poor eating habits, fatigue, irritability and social withdrawal. The main objective of the present study was to determine the prevalence and factors associated with depression and to identify measures that can be implemented to reduce risk factors of the disease among adults in Nyamitanga, Rugando and Rwanyamahembe sub-counties in Mbarara district. Methods. A cross-sectional design was used to capture data from a study sample size of 383 participants who were involved in completion of screening tests for depression. Scores from a 7-item version of Hopkins Symptom Checklist for Depression were averaged and the probable depression determined for each participant using a cut-off of 1.75. Logistic regression analyses were used to examine associations between depression outcomes and socio-demographic, behavioural and medical history variables. Results. The analyses revealed that the prevalence of depression among adults in the area stands at 27.7%. Depression was significantly associated with discrimination (AOR = 2.33, 95% CI = 1.22–4.45, P = 0.010), household size (AOR = 0.54, 95% CI = 0.32–0.93, P = 0.026), level of education (primary education: AOR = 0.36, 95% CI = 0.15–0.88, P = 0.024; secondary education: AOR = 0.30, 95% CI = 0.12–0.76, P = 0.011; tertiary education: AOR = 0.37, 95% CI = 0.15–0.92, P = 0.032) and drug-abuse related problems (AOR = 4.44, 95% CI = 1.34–14.74, P = 0.015). Measures for reducing the development of depression (which were identified by study participants) include guidance and counselling, awareness campaigns and self-help projects, improved access to quality medical services as well as stress management and spiritual care services. Conclusions. These findings show that depression prevalence in the study area, estimated at 27.7%, is high and worrying. Previous studies carried out in Mbarara district and other parts of Uganda have also reported similarly high estimates. They also show that discrimination, household size, level of education and drug-abuse are important risk factors associated with the prevalence of depressive disorders. Strategies targeted at early interventions and ultimately depression prevention need urgent attention in order to reduce risk factors of the disease.
OAJSM_A_324191 109..117

School of Kinesiology, Acadia University, Wolfville, NS, Canada Purpose: To gain an understanding of referee concussion knowledge, what sporting organizations were doing to prepare their referees to recognize concussions in youth sport, and what role referees could play in overall concussion safety. Materials and Methods: A total of 134 referees participated in the study across four provincial sporting organizations (rugby, soccer, ice hockey, and football). Participants completed a concussion knowledge questionnaire that explored knowledge about concussion education, recognition, management, preparedness, and the role of the referee in overall concussion management. Results: Overall, the sample was found to be moderately knowledgeable about concussions. Referees that received previous formal concussion education had statistically significant higher average scores when compared to those without formalized concussion education (P=0.001). However, only 24% of respondents reported receiving any formal education from their sporting body or referee organization. About 85% felt that referees could play an important role in concussion recognition in youth sport, but only 41% felt they were adequately equipped with the knowledge and skills to recognize these injuries. Conclusion: The findings from this study suggest that national, provincial, and individual sporting organizations should ensure that all stakeholders (including referees) are formally educated about concussions to encourage a safety-first environment for youth athletes. Educational sessions should focus on the general aspects of SRC while also focusing on the specific role of the referee in concussion recognition.
Title : The transcription factors ActR and SoxR differentially affect the phenazine tolerance of Agrobacterium tumefaciens Running title : Regulation of phenazine tolerance in A . tumefaciens

Bacteria in soils encounter redox-active compounds, such as phenazines, that can generate oxidative stress, but the mechanisms by which different species tolerate these compounds are not fully understood. Here, we identify two transcription factors, ActR and SoxR, that play contrasting yet complementary roles in the tolerance of the soil bacterium Agrobacterium tumefaciens to phenazines. We show that ActR promotes phenazine tolerance by proactively driving expression of a more energy-efficient terminal oxidase at the expense of a less-efficient alternative, which may affect the rate at which phenazines abstract electrons from the electron transport chain and thereby generate reactive oxygen species. SoxR, on the other hand, responds to phenazines by inducing expression of several efflux pumps and redox-related genes, including one of three copies of superoxide dismutase and five novel members of its regulon that could not be computationally predicted. Notably, loss of ActR is far more detrimental than loss of SoxR at low concentrations of phenazines, and also increases dependence on the otherwise functionally redundant SoxR-regulated superoxide dismutase. Our results thus raise the intriguing possibility that the composition of an organism’s electron transport chain may be the driving factor in determining sensitivity or tolerance to redox-active compounds.
Clinical Presentation

Myocarditis is a clinical syndrome characterized by inflammation of myocardium and caused by a myriad of etiologies including infectious, autoimmune, myocardial toxins, hy‐ persensitivity reactions and physical agents. Human myocarditis is most frequently caused by viral infection. Ongoing viral infection, myocardial injury, and adverse remodeling can lead to persistent ventricular dysfunction and dilated cardiomyopathy.