Miracle-dz/UniFAR-FTUs huggingface dataset:
Intervention for Cognitive Reserve Enhancement in Delaying the Onset of Alzheimer’s Symptomatic Expression (INCREASE) Study: Results from a Randomized Controlled Study of Medication Therapy Management Targeting a Delay in Prodromal Dementia Symptom Progression

Cognitive reserve has been hypothesized as a mechanism to explain differences in individual risk for symptomatic expression of Alzheimer’s Disease (AD). Inappropriate medications may diminish cognitive reserve, precipitating the transition from preclinical AD (pAD) to a symptomatic state. To date, there is limited data on the potential impact of medication optimization as a potential tool for slowing the symptomatic expression of AD. (1) To test the efficacy of a medication therapy management intervention designed to bolster cognitive reserve in community-dwelling older adults without dementia. (2) To evaluate the efficacy of intervention by baseline pAD status. A 1-year randomized controlled trial was conducted in community-dwelling older adults without dementia. Randomization was stratified by amyloid β positron emission tomography levels. Community-based, Lexington, Kentucky. Adults 65 years or older with no evidence of dementia and reporting at least one potentially inappropriate medication as listed in the Beers 2015 criteria were recruited. The study aimed to enroll 90 participants based on the a priori sample size calculation. Medication therapy management versus standard of care. Primary outcomes were: (1) one-year changes in the Medication Appropriateness Index; (2) one-year changes in Trail Making Test B under scopolamine challenge. The medication therapy management intervention resulted in significant improvement in Medication Appropriateness Index scores. Overall, there was no beneficial effect of the medication therapy management on Trail Making Test B scores, however stratified analysis demonstrated improvement in Trail Making Test B challenged scores associated with the medication therapy management for those with elevated amyloid β positron emission tomography levels consistent with pAD. Medication therapy management can reduce inappropriate medication use in older adults at risk for AD. Our study indicated beneficial cognitive effects in those with preclinical Alzheimer’s Disease. No statistically significant effects were evident in the study group as a whole, or in those without preclinical cerebral amyloidosis. Further work designed to improve the effectiveness of the medication therapy management approach and defining other preclinical pathologic states that may benefit from medication optimization are readily achievable goals for promoting improved cognitive health and potentially delaying the onset of symptomatic AD.
Photoinactivation of Yeast and Biofilm Communities of Candida albicans Mediated by ZnTnHex-2-PyP4+ Porphyrin

Candida albicans is the main cause of superficial candidiasis. While the antifungals available are defied by biofilm formation and resistance emergence, antimicrobial photodynamic inactivation (aPDI) arises as an alternative antifungal therapy. The tetracationic metalloporphyrin Zn(II) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin (ZnTnHex-2-PyP4+) has high photoefficiency and improved cellular interactions. We investigated the ZnTnHex-2-PyP4+ as a photosensitizer (PS) to photoinactivate yeasts and biofilms of C. albicans strains (ATCC 10231 and ATCC 90028) using a blue light-emitting diode. The photoinactivation of yeasts was evaluated by quantifying the colony forming units. The aPDI of ATCC 90028 biofilms was assessed by the MTT assay, propidium iodide (PI) labeling, and scanning electron microscopy. Mammalian cytotoxicity was investigated in Vero cells using MTT assay. The aPDI (4.3 J/cm2) promoted eradication of yeasts at 0.8 and 1.5 µM of PS for ATCC 10231 and ATCC 90028, respectively. At 0.8 µM and same light dose, aPDI-treated biofilms showed intense PI labeling, about 89% decrease in the cell viability, and structural alterations with reduced hyphae. No considerable toxicity was observed in mammalian cells. Our results introduce the ZnTnHex-2-PyP4+ as a promising PS to photoinactivate both yeasts and biofilms of C. albicans, stimulating studies with other Candida species and resistant isolates.
Animal models in lymph node transfer surgery: A systematic review

Background and Aim: Lymph node transfer surgery (LNTS) is indicated in secondary lymphedema (LE) patients who do not respond to conservative therapy. Animal models are the spearhead of LE research and were used to pioneer most of the surgical interventions currently in practice. We conducted a systematic review of the literature to explore animal models dedicated to LNTS to compare different species, techniques, and outcomes. Methods: Four databases were searched: PubMed, Cumulative Index of Nursing and Allied Health Literature, Scopus, and Web of Science. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis as our basis of organization. Results: Avascular lymph node graft (ALNG) and vascularized lymph node transfer (VLNT) effectively treated LE and lead to better outcomes than controls. Whole ALNGs are superior to fragmented ALNGs. Larger fragments are more likely to be reintegrated into the lymphatic system than small fragments. VLNT was superior to whole and fragmented ALNG. Increasing the number of VLNT resulted in better outcomes. Adipose-derived stem cells improved outcomes of VLNT; vascular endothelial growth factor C and D and platelet-rich plasma improved outcomes for ALNG. Cryopreservation of lymph nodes (LNs) did not affect outcomes for ALNG. The critical ischemia and venous occlusion time for LN flaps were 4-5 and 4 h, respectively. The critical time for reperfusion injury was 2 h. Some of the novel models included venous LNT, and cervical adipocutaneous flap to groin. Conclusion: Current evidence from animals favors VLNT over other surgical interventions. Several pharmacological therapies significantly improved outcomes of ALNG and VLNT. Relevance to Patients: LE is a chronic condition affecting millions of patients worldwide. LNTS is becoming more popular as a LE treatment. Animal models have led the LE research for decades and developing new models for LE are essential for LE research. This systematic review aims to summarize the existing animal models dedicated to LNTS. We believe that this review is critical to guide researchers in the selection of the model that is best fit for their hypothesis-driven experiments.
Use of a modified UTAUT model to investigate Emirati Citizens’ adoption of e-Government in Abu Dhabi

University of Wollongong Copyright Warning You may print or download ONE copy of this document for the purpose of your own research or study. The University does not authorise you to copy, communicate or otherwise make available electronically to any other person any copyright material contained on this site. You are reminded of the following: This work is copyright. Apart from any use permitted under the Copyright Act 1968, no part of this work may be reproduced by any process, nor may any other exclusive right be exercised, without the permission of the author. Copyright owners are entitled to take legal action against persons who infringe their copyright. A reproduction of material that is protected by copyright may be a copyright infringement. A court may impose penalties and award damages in relation to offences and infringements relating to copyright material. Higher penalties may apply, and higher damages may be awarded, for offences and infringements involving the conversion of material into digital or electronic form. Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.
Empirical Modeling and Optimization of Base Activated Ngbo Catalysts in Esterification Reaction Using Response Surface Methodology

In this work, Box-Behnken’s Response Surface Methodology (RSM) was applied to study the esterification reaction effectiveness of base-activated Ngbo clay catalyst. The esterification was monitored based on temperature, time duration, amount of reactant, catalyst weight, and particle size. The Box-Behnken’s Response Surface Methodology indicates that the base clay-catalyzed esterification reactions proceed through dual Acid-complex and Alcohol- complex mechanisms, with the alcohol mechanism dominating. The acetic acid and ethanol esterification efficiencies by base-activated Ngbo clay catalyst optimized using RSM models indicated the esterification percentage was ˃99%. The predicted and experimental values under the same conditions showed less than 5% difference, thereby making the Box-Behnken design approach an efficient, effective, and reliable method for the esterification of acetic acid with ethanol. The produced catalyst was optimized using A-One way ANOVA modelled, which indicated that the correlation coefficient of the regression was 0.9940. The result implied that 99.40% of the total variation in the esterification reaction was due to the experimental variables. The obtained data in this study indicated that this process could be applied in the esterification of acetic acid to avoid the drawbacks of corrosion, loss of catalyst, and environmental problems.
Cash shortfall, SEO offer size, and SEO announcement returns

We examine the announcement returns of 3483 seasoned equity offerings (SEOs) during the 1996–2018 period. Although there is a significant decline in SEO announcement returns, we show that cash shortfall in the year before SEO has a positive impact on SEO announcement returns. By matching SEO offers sizes and cash shortfalls, we also find that negative announcement-period returns become positive when SEO offer size is determined in concert with cash shortfall. Patterns of long-run abnormal firm performance after SEO announcements are consistent with those we document for the announcement-period returns. Our results suggest that cash shortfall in the year before SEO as indication of funds needs mitigates agency spending of SEO proceeds, and thus, the market welcomes the SEO announcement with positive stock price reactions.
Decades of Genetic Research on Soybean mosaic virus Resistance in Soybean

This review summarizes the history and current state of the known genetic basis for soybean resistance to Soybean mosaic virus (SMV), and examines how the integration of molecular markers has been utilized in breeding for crop improvement. SVM causes yield loss and seed quality reduction in soybean based on the SMV strain and the host genotype. Understanding the molecular underpinnings of SMV–soybean interactions and the genes conferring resistance to SMV has been a focus of intense research interest for decades. Soybean reactions are classified into three main responses: resistant, necrotic, or susceptible. Significant progress has been achieved that has greatly increased the understanding of soybean germplasm diversity, differential reactions to SMV strains, genotype–strain interactions, genes/alleles conferring specific reactions, and interactions among resistance genes and alleles. Many studies that aimed to uncover the physical position of resistance genes have been published in recent decades, collectively proposing different candidate genes. The studies on SMV resistance loci revealed that the resistance genes are mainly distributed on three chromosomes. Resistance has been pyramided in various combinations for durable resistance to SMV strains. The causative genes are still elusive despite early successes in identifying resistance alleles in soybean; however, a gene at the Rsv4 locus has been well validated.
Plankton hitch-hikers on naturalists’ instruments as silent intruders of aquatic ecosystems: current risks and possible prevention

Organism dispersal is nowadays highly driven by human vectors. This also refers to the aquatic organisms that can often silently spread in and invade new waters, especially when human vectors of dispersal act without brakes. Thus, it is mandatory to continuously identify human-mediated mechanisms of organism dispersal and implement proper biosecurity treatments. In this study, we demonstrate how the plankton net – one of the basic instruments in the equipment of every plankton sampling person is a good vector for plankton dispersal and invasions. We also demonstrate whether keeping the net in an ethanol solution after sampling is a proper biosecurity treatment, and what kind of treatments are implemented by people worldwide. The first simulation shows that bloom-forming cyanobacteria can easily infiltrate into the new environment thanks to the nets, and can prosper there. However, ethanol-based biosecurity treatment efficiently prevented their spread and proliferation in the new environment. The second simulation, based on wild plankton from an eutrophic lake, indicates that a plethora of phyto- and zooplankton taxa can infiltrate into the new waterbody through the net and sustain themselves there if the net is only flushed in the waterbody and left to dry after sampling (an approach that is commonly used by naturalists). Here, we also show that native plankton residents strongly shape the fate of hitch-hikers, but some of them like cyanobacteria can successfully compete with residents. Survey data alert us to the fact that the vast majority of biologists use either ineffective or questionable biosecurity treatments and only less than a tenth of samplers implement treatments based on disinfectant liquids. Our results emphasize that the lack of proper biosecurity methods implemented by the biologists facilitates the spread and invasions of plankton including also invasive species of a great nuisance to native ecosystems. Considering that naturalists usually use different instruments that might also be good vectors of plankton dispersal, it is necessary to develop proper uniform biosecurity treatments. No longer facilitating the plankton spread through hydrobiological instruments is the milestone that we, plankton samplers worldwide, should achieve together in the nearest future if we want to continue our desire to explore, understand, protect and save nature.
Different Methods for Evaluating Microglial Activation Using Anti-Ionized Calcium-Binding Adaptor Protein-1 Immunohistochemistry in the Cuprizone Model

Microglia play an important role in the pathology of various central nervous system disorders, including multiple sclerosis (MS). While different methods exist to evaluate the extent of microglia activation, comparative studies investigating the sensitivity of these methods are missing for most models. In this study, we systematically evaluated which of the three commonly used histological methods (id est, quantification of microglia density, densitometrically evaluated staining intensity, or cellular morphology based on the determination of a ramification index, all measured in anti-ionized calcium-binding adaptor protein-1 (IBA1) immunohistochemical stains) is the most sensitive method to detect subtle changes in the microglia activation status in the context of MS. To this end, we used the toxin-induced cuprizone model which allows the experimental induction of a highly reproducible demyelination in several central nervous system regions, paralleled by early microglia activation. In this study, we showed that after 3 weeks of cuprizone intoxication, all methods reveal a significant microglia activation in the white matter corpus callosum. In contrast, in the affected neocortical grey matter, the evaluation of anti-IBA1 cell morphologies was the most sensitive method to detect subtle changes of microglial activation. The results of this study provide a useful guide for future immunohistochemical evaluations in the cuprizone and other neurodegenerative models.
Symbol level decoding of Reed-Solomon codes with improved reliability information over fading channels

Engineering and the Built Environment School of Electrical and Information Engineering Doctor of Philosophy SYMBOL LEVEL DECODING OF REED-SOLOMON CODES WITH IMPROVED RELIABILITY INFORMATION OVER FADING CHANNELS by Olayinka Olaolu Ogundile Supervisor: Dr. D.J.J. Versfeld Reliable and efficient data transmission have been the subject of current research, most especially in realistic channels such as the Rayleigh fading channels. The focus of every new technique is to improve the transmission reliability and to increase the transmission capacity of the communication links for more information to be transmitted. Modulation schemes such as M -ary Quadrature Amplitude Modulation (M -QAM) and Orthogonal Frequency Division Multiplexing (OFDM) were developed to increase the transmission capacity of communication links without additional bandwidth expansion, and to reduce the design complexity of communication systems. On the contrary, due to the varying nature of communication channels, the message transmission reliability is subjected to a couple of factors. These factors include the channel estimation techniques and Forward Error Correction schemes (FEC) used in improving the message reliability. Innumerable channel estimation techniques have been proposed independently, and in combination with different FEC schemes in order to improve the message reliability. The emphasis have been to improve the channel estimation performance, bandwidth and power consumption, and the implementation time complexity of the estimation techniques.
Misinformation and professional news on largely unmoderated platforms: the case of telegram

ABSTRACT To date, there is little research to measure the scale of misinformation and understand how it spreads on largely unmoderated platforms. Our analysis of 200,000 Telegram posts demonstrates that links to known sources of misleading information are shared more often than links to professional news content, but the former stays confined to relatively few channels. We conclude that, contrary to popular received wisdom, the audience for misinformation is not a general one, but a small and active community of users. Our study strengthens an empirical consensus regarding the spread of misinformation and expands it for the case of Telegram.
Hope and Quality of the life of People living with HIV: A Cross-Sectional Study at ART Center, Bagalkot, Karnataka

Background: HIV/AIDS emerged as the most important public health issue of the late twentieth and early twenty-first centuries. Hope & Quality of life (QoL) of People living with HIV/AIDS are affected by multiple socio-demographic variables as a major predictor of Hope & QoL. Methods: This cross-sectional descriptive survey research design included a sample of 430 PLHIV attending the ART centre, District Government Hospital, Bagalkot. Data were collected using the self-report method and Hospital records by socio-demographic questionnaire, Herths Hope Scale and WHO QOLHIV-BREF scale. Pearson's Correlations, chi-square test and multiple linear regression analysis were used. Results: A significant positive association was found between Hope and QoL among PLHIV (r= 0.483, p<0.001 ). A significant regression equation (F 429, 42= 1.842, R 2 =0.167, p<0.01 ). Married status i.e. married, Occupation i.e. doing Labor work has positively and 3 rd and 4 th clinical-stage have negatively predicted Hope of PLHIV. A Non significant regression equation (F 429,42 =1.37, R 2 =0.13, p<0.05 ). Being a private employee had positively and Heterosexual had negatively predicted and remained determinants have not predicted QoL among PLHIV and there was a significant association found between marital status and remained variables are not associated with Hope. There was a significant negative relationship found between Family monthly income and a positive relationship found between the duration of HIV and QoL. Marital status is significantly associated with QoL. Conclusions: The overall findings reveals that a significant positive correlation between Hope and QoL among PLHIV. There was a significant association found between marital status with Hope. There was a significant negative relationship found between Family monthly income and positive relationship found Duration of HIV and QoL.
Food behaviors accounting for the recent trends in dietary fatty acid profiles among Korean adults

BACKGROUND/OBJECTIVES This study examined the changes in food behaviors of dietary fatty acids over 2007–2018 among Korean adults. SUBJECTS/METHODS This study used data from the 4th (2007–2009), 5th (2010–2012), 6th (2013–2015), and 7th (2016–2018) Korea National Health and Nutrition Examination Surveys. A total of 46,307 adults aged 19–64 yrs were selected and dietary data were obtained from a single 24-h recall. In the 4th and 7th data, the major food sources for each fatty acid based on the contributing percentage of the food item were compared. The consumption trends in the major food sources were presented as grams per day over 2007–2018 and compared across the survey periods using the multiple regression model. RESULTS From 2007 to 2018, for total fat, saturated fatty acid (SFA), and monounsaturated fatty acid, the contribution of animal food sources, including beef, chicken, and eggs increased but plant food sources (e.g., tofu, soybean, and plant oil) decreased. As polyunsaturated fatty acid sources, mayonnaise, eggs, and bread showed higher contributions, whereas soybean and tofu showed lower contributions in the 7th data compared to the 4th data. For n-3 fatty acids, the contribution of fish decreased between the 4th and 7th data. Over 12 yrs, the significant increases in the absolute amount of consumption from animal sources were observed. In contrast, decreases in the consumption from plant sources and fish were seen across the survey periods. CONCLUSIONS In Korean adults, increases in the intake of dietary fatty acids along with changes in the food behaviors during 2007–2018 have evoked great concern for SFA intake, which is a cardiovascular disease risk factor. Healthy food sources of dietary fatty acids should be emphasized in this population.
Phytochemical Characterization of Citrus-Based Products Supporting Their Antioxidant Effect and Sensory Quality

The increasing attention on the impact of food on human and environmental health has led to a greater awareness about nutrition, food processing, and food waste. In this perspective, the present work deals with the investigation of the chemical non-volatile and volatile profiles of two Citrus-based products, produced through a conscious process, using Citrus peels as natural gelling agents. Moreover, the total polyphenol content (TPC) and the antioxidant properties were evaluated, as well as their sensorial properties. Chemical and antioxidant results were compared with those of Citrus fresh fruits (C. reticulata, C. sinensis, and C. limon). Concerning the non-volatile fingerprint, the two samples showed a very similar composition, characterized by flavanones (naringenin, hesperetin, and eriodyctiol O-glycosides), flavones (diosmetin and apigenin C-glucosides), and limonoids (limonin, nomilinic acid, and its glucoside). The amount of both flavonoids and limonoids was higher in the Lemon product than in the Mixed Citrus one, as well as the TPC and the antioxidant activity. The aroma composition of the two samples was characterized by monoterpene hydrocarbons as the main chemical class, mainly represented by limonene. The sensorial analysis, finally, evidenced a good quality of both the products. These results showed that the most representative components of Citrus fruits persist even after the transformation process, and the aroma and sensorial properties endow an added value to Citrus preparations.