Miracle-dz/UniFAR-FTUs huggingface dataset:
A distinct impact of repeated morphine exposure on synaptic plasticity at Schaffer collateral‐CA1, temporoammonic‐CA1, and perforant pathway‐dentate gyrus synapses along the longitudinal axis of the hippocampus

We aimed to study how morphine affects synaptic transmission in the dentate gyrus and CA1 regions along the hippocampal long axis. For this, recording and measuring of field excitatory postsynaptic potentials (fEPSPs) were utilized to test the effects of repeated morphine exposure on paired‐pulse evoked responses and long‐term potentiation (LTP) at Schaffer collateral‐CA1 (Sch‐CA1), temporoammonic‐CA1 (TA‐CA1) and perforant pathway‐dentate gyrus (PP‐DG) synapses in transverse slices from the dorsal (DH), intermediate (IH), and ventral (VH) hippocampus in adult male rats. After repeated morphine exposure, the expression of opioid receptors and the α1 and α5 GABAA subunits were also examined. We found that repeated morphine exposure blunt the difference between the DH and the VH in their basal levels of synaptic transmission at Sch‐CA1 synapses that were seen in the control groups. Significant paired‐pulse facilitation of excitatory synaptic transmission was observed at Sch‐CA1 synapses in slices taken from all three hippocampal segments as well as at PP‐DG synapses in slices taken from the VH segment in the morphine‐treated groups as compared to the control groups. Interestingly, significant paired‐pulse inhibition of excitatory synaptic transmission was observed at TA‐CA1 synapses in the DH slices from the morphine‐treated group as compared to the control group. While primed‐burst stimulation (a protocol reflecting normal neuronal firing) induced a robust LTP in hippocampal subfields in all control groups, resulting in a decaying LTP at TA‐CA1 synapses in the VH slices and at PP‐DG synapses in both the IH and VH slices taken from the morphine‐treated rats. In the DH of morphine‐treated rats, we found increased levels of the mRNAs encoding the α1 and α5 GABAA subunits as compared to the control group. Taken together, these findings suggest the potential mechanisms through which repeated morphine exposure causes differential changes in circuit excitability and synaptic plasticity in the dentate gyrus and CA1 regions along the hippocampal long axis.
On radial flow between parallel disks

Approximate analytical solutions are presented for converging flow in between two parallel non rotating disks. The static pressure distribution and radial component of the velocity are developed by averaging the inertial term across the gap in between parallel disks. The predicted results from the first approximation are favourable to experimental results as well as results presented by other authors. The second approximation shows that as the fluid approaches the center, the velocity at the mid channel slows down which is due to the struggle between the inertial term and the flowrate.
ENERGY GAP IN SUPERCONDUCTORS CONTAINING PARAMAGNETIC IMPURITIES

Experiments were performed on quenched alloy films evaporated onto substrates maintained at 4 deg K to investigate the energy gap and density of states of semiconductors containing paramagnetic impurities. Preliminary results are presented from an investigation by tunneling techniques. For paramagnetic impurity concentrations greater than a relatively small value, the superconductor no longer exhibits an energy gip in its tunneling characteristics, although resistance measurements show that it has a welldefined transition temperature in accord with the expected concentration dependence. (H.D.R.)
Fast and Slow Subpolar Ocean Responses to the North Atlantic Oscillation: Thermal and Dynamical Changes

Climate model hindcasts are analyzed to reveal the impacts of the North Atlantic Oscillation (NAO) on the North Atlantic subpolar ocean, which exhibits variability on seasonal to decadal timescales. The ocean response to a single winter NAO event is separated into fast and slow responses. The fast response persists over winter–spring seasons, during which wind stress and heat flux anomalies associated with the NAO rapidly modify ocean temperatures via changes in Ekman transport and ocean‐atmosphere heat exchanges. The slow response persists for 3–4 years, during which overturning and gyre circulations redistribute opposing‐signed surface temperature anomalies created by the NAO. This redistribution modifies east‐west temperature contrasts altering the meridional heat transport associated with gyres and changing the strength of the overturning circulation. Hence, the fast and slow responses lead to opposing‐signed subpolar temperature anomalies in time from the competing effects of local forcing and horizontal heat convergence.
Age-Optimized Multihop Information Update Mechanism on the LEO Satellite Constellation via Continuous Time-Varying Graphs

Low orbit satellite constellation as a relay network provides a possible solution for remote real-time data gathering applications, in which freshness information updates will be forwarded via dynamical intersatellite links (ISLs). Modeling by a time-varying network, this article studies minimizing Age of Information (AoI) of delivering the data through a multihop path, in particular, focusing on the effect of frequent interruptions of ISLs. Subjected to two constraints of path and effective arrival rate, the minimizing AoI problem is formulated to find a pair of optimal transmission delay and arrival rate. In particular, the $\mathcal {H}$ -approximate optimal algorithm, called a latest update routing (LUR) algorithm, is proposed with a well-designed continuous time-varying graph. Using LUR, a set of paths can be obtained with degraded transmission delay that satisfies a given arrival rate. By screening all the arrival rates satisfying the effective constraint, the maximum rate and a corresponding path set that minimizes age can be found. The simulation results verified that a degraded average AoI can be obtained by the proposed path selection mechanism compared with the typical shortest delay path (SDP) strategy, minimum spanning tree (MST) strategy, and MAoIG. In particular, the numerical findings show that the proposed LUR reduces average AoI by a maximum of 12.66% compared with SDP, 75.28% compared with MST, and 69.3% compared with MAoIG, respectively, under different scenarios.
Probable detection of radial magnetic field gradients in the atmospheres of Ap stars

For the first time the possible presence of radial gradients of magnetic fields in the atmospheres of three magnetic Ap stars has been critically examined by measurements of the mean magnetic field modulus from spectral lines resolved into magnetically split components lying on the different sides of the Balmer jump. A number of useful diagnostic lines below and above the Balmer discontinuity, only slightly affected by blends, with simple doublet and triplet Zeeman pattern have been identified from the comparison between synthetic spectra computed with the SYNTHMAG code and the high resolution and S/N spectra obtained in unpolarized light with the ESO VLT UVES spectrograph. For all three stars of our sample, HD 965, HD 116114 and 33 Lib, an increase of the magnetic field strength of the order of a few hundred Gauss has been detected bluewards of the Balmer discontinuity. These results should be taken into account in future modelling of the geometric structure of Ap star magnetic fields and the determination of the chemical abundances in Ap stars with strong magnetic fields.
Effectiveness of percutaneous epidural neuroplasty using a balloon catheter in patients with chronic spinal stenosis accompanying mild spondylolisthesis: a longitudinal cohort study

Background Degenerative lumbar spondylolisthesis (DLS) is frequently associated with lumbar spinal stenosis (LSS) and conservative treatments such as epidural steroid injection do not have long-term benefits in LSS patients with DLS. This study evaluated the effectiveness of percutaneous epidural neuroplasty using a balloon catheter in patients with LSS and DLS. Methods Patients’ sex, age, body mass index, diabetes, hypertension, stenosis grading, pain duration, location, pain intensity, and medications were retrieved from electronic medical records. At 1, 3, and 6 months following the procedure, data on pain severity, medication usage, and physical functional status were analyzed. A generalized estimating equations model was used at the six-month follow-up. Patients were divided into those with DLS (the spondylolisthesis group) and those without DLS (the no spondylolisthesis group) to evaluate whether the effects of percutaneous epidural neuroplasty using a balloon catheter were different. Results A total of 826 patients were included (spondylolisthesis 433 patients, 52.4%; no spondylolisthesis 393 patients, 47.6%). Age, body mass index, hypertension, pain location, and stenosis grading were statistically different between the two groups. The generalized estimating equations analyses with unadjusted and adjusted estimation revealed a significant improvement in the estimated mean numerical rating scale of pain intensities compared to that at baseline in both groups (P < 0.001). Any adverse events that occurred were minor and temporary. Conclusions Percutaneous epidural neuroplasty using a balloon catheter may be an alternative treatment option for patients with chronic LSS, regardless of accompanying DLS, who have had failed conservative management.
The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions

Abstract A binary classification of the pathogenic immune reactions as anti-inflammatory high-Treg reactions or pro-inflammatory low-Treg reactions explains both the relatively low incidence rate of several types of cancer, and the relatively high incidence rate of herpes zoster cases diagnosed in the summer compared to cases diagnosed in the winter (in regions with temperate climate). This binary model also elucidates the longer survival of cancer patients diagnosed during the summer compared to these diagnosed in the winter. The three key elements of this explanation are: (a) the effect of sunlight on Treg production; (b) the evolvement of cancer from a low-Treg condition at early stage, to a high-Treg condition at advanced stage, and (c) the evolvement of herpes zoster from a high-Treg condition at pre-exudative stage to a low-Treg condition at acute exudative stage. A significant proportion of indolent tumors at the time of diagnosis (>20%) is a prerequisite for a beneficial effect of sunlight on cancer incidence rate and prognosis. This prerequisite restricts the beneficial effect of diagnosis during summer to certain types of cancer. Clinical implication: the prognosis of early stage tumors may be improved by a course of corticosteroid (or other immunosuppressant) treatment.
SARS‐CoV‐2 infection of companion animals in Egypt and its risk of spillover

Abstract Background Reverse zoonoses occur because of interactions between humans and animals. Homology of ACE‐2 cell receptors in different hosts and high mutation rate of SARS‐CoV‐2 enhance viral transmission among species. Objectives This study aimed to investigate spillover of SARS‐CoV‐2 between humans and companion animals. Methods A cross‐sectional study was constructed using nasopharyngeal/oropharyngeal swabs, serum and blood samples collected from 66 companion animals (33 cats and 33 dogs) that were in contact with SARS‐CoV‐2‐positive owners from December 2020 to March 2021. Swabs were screened by rRT‐PCR and some positive cases were confirmed by partial spike gene sequencing. Clinical pathology and pathological studies were also performed. Results Our findings revealed that 30% of cats (10/33) and 24% of dogs (8/33) were SARS‐CoV‐2 positive. While 33% of these animals were asymptomatic (6/18), 28% showed mild respiratory signs (5/18) and 39% displayed severe respiratory signs (7/18) including 4 dead cats 40% (4/10). Partial spike gene sequencing of 6 positive samples collected in December 2020 were identical to SARS‐CoV‐2 that was detected in humans in Egypt in that time frame. Clinical pathology findings revealed thrombocytopenia, lymphocytopenia, as well as elevated levels of D‐dimer, LDH, CRP, and ferritin. Post‐mortem and histopathological examinations illustrated multisystemic effects. Conclusions There is a potential occurrence of SARS‐CoV‐2 spillover between humans and pet animals. Impacts The present study highlighted the potential occurrence of SARS‐CoV‐2 spillover between humans and their companion animals. Biosecurity measures should be applied to decrease spread of SARS‐CoV‐2 among humans and pet animals.
A Haplotype-Based GWAS Identified Trait-Improving QTL Alleles Controlling Agronomic Traits under Contrasting Nitrogen Fertilization Treatments in the MAGIC Wheat Population WM-800

The multi-parent-advanced-generation-intercross (MAGIC) population WM-800 was developed by intercrossing eight modern winter wheat cultivars to enhance the genetic diversity present in breeding populations. We cultivated WM-800 during two seasons in seven environments under two contrasting nitrogen fertilization treatments. WM-800 lines exhibited highly significant differences between treatments, as well as high heritabilities among the seven agronomic traits studied. The highest-yielding WM-line achieved an average yield increase of 4.40 dt/ha (5.2%) compared to the best founder cultivar Tobak. The subsequent genome-wide-association-study (GWAS), which was based on haplotypes, located QTL for seven agronomic traits including grain yield. In total, 40, 51, and 46 QTL were detected under low, high, and across nitrogen treatments, respectively. For example, the effect of QYLD_3A could be associated with the haplotype allele of cultivar Julius increasing yield by an average of 4.47 dt/ha (5.2%). A novel QTL on chromosome 2B exhibited pleiotropic effects, acting simultaneously on three-grain yield components (ears-per-square-meter, grains-per-ear, and thousand-grain-weight) and plant-height. These effects may be explained by a member of the nitrate-transporter-1 (NRT1)/peptide-family, TaNPF5.34, located 1.05 Mb apart. The WM-800 lines and favorable QTL haplotypes, associated with yield improvements, are currently implemented in wheat breeding programs to develop advanced nitrogen-use efficient wheat cultivars.
Benthic Pleurocapsales (Cyanobacteria) Blooms Catalyzing Carbonate Precipitation and Dolomitization Following the End‐Permian Mass Extinction

The widespread development of Permian/Triassic boundary microbialites is a key biosedimentary response to the mass extinction event. The microbial communities that precipitated these structures remain, however, poorly resolved. Here, we report abundant columnar microfossils from five Permian‐Triassic successions in South China. Four phases of the microfossil life cycle are recorded: baeocytes, juvenile column, mature column, and baeocyte‐splitting, which are interpreted as Pleurocapsales (cyanobacterial clade that reproduces by multiple fission). The great thickness (up to 13 m) of these microbial deposits and Raman spectrum analysis indicate a strong calcification capacity of the Pleurocapsales. Pronounced peaks of Mg/(Mg + Ca) ratios from microbialite and distinct Mg‐enrichment in microfossils indicate that Pleurocapsales blooms may also have facilitated dolomitization of the microbialites. Common occurrence, strong biomineralization capacity, baffling framework, and the close association with carbonate minerals suggest that Pleurocapsales were key constructors of post‐extinction microbialites.
Low serum complement level is associated with higher mortality in tuberculous meningitis: a retrospective cohort study

Purpose We evaluated the associations between serum complement levels and tuberculous meningitis (TBM), bacterial meningitis (BM), and viral meningitis (VM), as well as the association between serum complement levels and mortality in TBM. Methods Background information and blood/cerebrospinal fluid analysis results were collected from 2009 to 2019. Patients who had serum complement level data collected at admission and who were diagnosed with TBM (n = 97), BM (n = 31), or VM (n = 557) were enrolled. Results Initial serum complement levels were significantly lower in the TBM group than the VM group in both the total population and the propensity score-matched population. In the TBM and VM groups, compared to patients with initial highest-quartile C4 level, patients in the lowest quartile (C4 < 24.3 mg/dL) had significantly greater odds of TBM diagnosis (odds ratio, 2.2; 95% confidence interval, 1.0–4.5; p = 0.038). In the TBM group, patients with the lowest-quartile C3 level (<96.9 mg/dL) experienced a significantly higher 90-day mortality rate compared to other TBM patients (hazard ratio, 19.0; 95% confidence interval, 2.1–167.4.5; p = 0.008). Conclusion Both serum C3 and C4 levels were significantly lower in the TBM group than in the VM group. TBM patients with lower serum C3 level had a significantly higher mortality rate than those with higher C3 level.
West Africa Dwarf sheep management systems and exposure to potential stressors in the savannah agroecological zone of Ghana

This study was conducted in the savannah agroecological zone of Ghana to assess the different sheep management systems and identify potential stressors that compromise sheep productivity under these systems. A questionnaire and on-farm observations were used to obtain data from 176 farms on management system types, resources, husbandry practices and productivity. Four management systems were identified in the study area, namely extensive (41.5%), semi-intensive (38.1%), intensive (6.3%) and tethering (14.2%). Feeding systems used were free grazing/scavenging (24.43%), herded grazing (17.05%), zero-grazing/intensive feeding (6.25%), grazing plus supplementation (38.07%) and restricted grazing in the rainy season (14.2%). Most (87%) farmers under the extensive system did not house their sheep at all, but 88.1% of farmers using the semi-intensive system housed their sheep year round. Floor spacing per sheep was 1.06, 2.31, 2.17 and 1.47 sheep/m2 for the intensive, semi-intensive, extensive, and tethering, respectively. Preweaning mortality was significantly higher (40%) than post-weaning to yearling (34.9%) and adult mortality rates (14.3%) (ꭓ2 = 292, P <0.001). The extensive system has the highest (32.8%) mortality rate and the intensive system the least (14.9%) (ꭓ2 = 151, P <0.001). Reproductive indices (lambing percentage, age at first lambing, lambing intervals, and abortion rates) were all significantly influenced by the management system, with sheep managed under the semi-intensive and intensive systems performing better than sheep managed under the extensive system and tethering. Extensive management and tethering of sheep may expose Djallonké sheep to disease stress, chronic undernutrition, heat stress and walking stress compared to sheep under more intensive systems.
Religious and Patriarchal Beliefs that Influence Christian Women to Persevere in Abusive Relationships: With Reference to Giriama People, Kenya

This article examines how cultural beliefs and patriarchal practices during the early period of the spread of Christianity promoted intimate partner violence (IPV) against women in the church. The article begins by exploring some cultural and patriarchal beliefs that were practised by the Jews and Giriama people during the pre-evangelistic period that promoted IPV against women through religious and cultural practices to see violence as normal, thus choosing to persevere in violent relationships. New strategies for preventing IPV against women have been discussed. In this descriptive research, data were collected from 52 informants using questionnaires and in-depth interviews. The study interviewed 30 women facing IPV individually. Abused women provided information in focus group discussions. Ten pastors were sampled in order to gather data on how cultural and patriarchal practices with the support of biased biblical interpretation of texts, promoted IPV against Christian women. Twelve questionnaires were administered to six gender officers, three probation officers and three social workers, and the findings were used to supplement data collected from the key informants. This study established that some Bible texts are interpreted and used by wife abusers and pastors offering counselling to the IPV victims to promote and justify IPV. It, therefore, recommended that the church should organise to re-read and re-learn these Bible texts with a view to interpreting them without being biased against women. The church should also re-examine all patriarchal passages in the Bible with a view to facilitating contextual and reasoned scrutiny of the male-controlled beliefs and practices that promote IPV against women. The article established that cultural beliefs and patriarchal practices promote IPV against women. Some pastors and wife abusers interpret some Bible verses to justify spousal abuse; however, if the problem of IPV is to be prevented, the church, the government, and other stakeholders involved in a war against IPV on women must embrace new strategies that are free from cultural and patriarchal beliefs and practices.
Zigzag and Breakup Instabilities of Stripes and Rings in the Two‐Dimensional Gray–Scott Model

Two different types of instabilities of equilibrium stripe and ring solutions are studied for the singularly perturbed two‐component Gray–Scott (GS) model in a two‐dimensional domain. The analysis is performed in the semi‐strong interaction limit where the ratio O(ɛ−2) of the two diffusion coefficients is asymptotically large. For ɛ→ 0, an equilibrium stripe solution is constructed where the singularly perturbed component concentrates along the mid‐line of a rectangular domain. An equilibrium ring solution occurs when this component concentrates on some circle that lies concentrically within a circular cylindrical domain. For both the stripe and the ring, the spectrum of the linearized problem is studied with respect to transverse (zigzag) and varicose (breakup) instabilities. Zigzag instabilities are associated with eigenvalues that are asymptotically small as ɛ→ 0. Breakup instabilities, associated with eigenvalues that are O(1) as ɛ→ 0, are shown to lead to the disintegration of a stripe or a ring into spots. For both the stripe and the ring, a combination of asymptotic and numerical methods are used to determine precise instability bands of wavenumbers for both types of instabilities. The instability bands depend on the relative magnitude, with respect to ɛ, of a nondimensional feed‐rate parameter A of the GS model. Both the high feed‐rate regime A=O(1), where self‐replication phenomena occurs, and the intermediate regime O(ɛ1/2) ≪A≪O(1) are studied. In both regimes, it is shown that the instability bands for zigzag and breakup instabilities overlap, but that a zigzag instability is always accompanied by a breakup instability. The stability results are confirmed by full numerical simulations. Finally, in the weak interaction regime, where both components of the GS model are singularly perturbed, it is shown from a numerical computation of an eigenvalue problem that there is a parameter set where a zigzag instability can occur with no breakup instability. From full‐scale numerical computations of the GS, it is shown that this instability leads to a large‐scale labyrinthine pattern.