Miracle-dz/UniFAR-FTUs huggingface dataset:
ANTISICKLING ACTIVITY AND MINERAL CONTENT OF HURA CREPITANS L., ALTERNANTHERA BETTZICKIANA (REGLE) G. NICHOLSON AND DISSOTIS BRAZZAE COGN, PLANTS USED IN THE MANAGEMENT OF SICKLE CELL DISEASE IN KWILU PROVINCE, DEMOCRATIC REPUBLIC OF THE CONGO

study was to determine the mineral three used in Congolese traditional medicine sickle cell in order explore the mineral composition of Congolese phytotherapeutic plant. ABSTRACT This study was initiated to determine the qualitative and quantitative mineral composition and the antisickling activity of three plants mostly used in Congolese traditional medicine for the management of sickle cell disease in Kwilu province, Democratic Republic of the Congo. Qualitative and quantitative analyses of the mineral composition of the leaves of Alternanthera bettzickiana , Dissotis brazzae and the barks of Hura crepitans harvested in Kwilu province were carried out using the fluorescence spectrometric and ICP-OES methods. The results obtained in this study showed that 23 mineral elements were present in the three plants studied, including macroelements such as Potassium (K), Phosphorus (P), Calcium (Ca), Sodium (Na), Magnesium (Mg), Sulfur (S), Chlorine (Cl) and micro elements such as: Aluminum (Al), Silicon (Si), Vanadium (V), Chrome (Cr), Manganese (Mn), Iron (Fe), Nickel (Ni), Copper (Cu), Zinc (Zn), Selenium (Se), Bromine (Br), Molybdenum (Molybdenum), Tin (Sn), Barium (Ba) and Lead (Pb). Some of these elements are related to sickle cell disease, such as Iron, Zinc, Selenium, Copper, Calcium, Magnesium and Manganese. Calcium and potassium were found in higher content while lead, brome, copper and nickel were found in trace content. The crude extracts of these plants have showed good correction of sickling of red blood cells which pass from the sickled form to the normal one. It has been also found that, the anthocyanins extracted from these three plants increase the hydration ability of red blood cells.
Hybrid Model using Stack-Based Ensemble Classifier and Dictionary Classifier to Improve Classification Accuracy of Twitter Sentiment Analysis

Ensemble classifiers are widely used for the enhancement of accuracy of twitter sentiment classification. In the present research, a hybrid model based on stack based ensemble classifiers and dictionary based classifier is used for tweet classification as positive and negative. To enhance accuracy of classification, sentiment score retrieved from dictionary based classifier is added to the feature vector to get enhanced feature set and the hybrid stack based ensemble model is implemented on this enhanced feature set. Three machine learning classifiers svmRadial, C5.0, NB are used to build stacked based ensemble classifier using GLM and RF as Meta learners. Three data sets viz. Kaggle - US Airline Twitter Sentiment Data Set, Sentiment 140 Twitter Data Set, and Real time manually labeled data set related to ‘Clean India Mission’ are used for the implementation of the proposed model. Caret library of R Studio is used for creating the stack based ensemble of classifiers. The results show that the proposed hybrid model that used sentiment score as one of the features in feature set performed better with an accuracy of 0.8742223 for Kaggle - US Airline Twitter Sentiment Data Set, 0.8881453 for data set related to ‘Clean India Mission’ and 0.9953593 for Sentiment 140 Twitter Data Set, as compared to machine learning classifiers and other ensemble classifiers.
DNA Methylation and Expression of HLA-DROL

B-cell lines established from two individuals with T-cell acute lymphocytic leukemia (T-ALL) express HLA-DR antigens, whereas the isogenic T-cells do not. The lack of expression correlates with a lack of detectable HLA-DR mRNA. All of the DRcx DNA sequences detected by a cloned DRc cDNA probe are contained in a BglII fragment which varies slightly in size (4.0 to 4.8 kilobases) from one individual to another. In DNA from the T-cells not expressing DRot mRNA, all of the potential HpaII sites within the BglII fragment appeared to be methylated. In contrast, at least some of these sites were not methylated in DNA from the B-cells expressing high levels of DRa mRNA. Treatment of these T-cells with 5-azacytidine resulted in the induction of DR surface antigen expression, the appearance of DRcx mRNA, and the partial demethylation of the DRcx DNA sequences. T-cell lines established from human T-cell leukemia-lymphoma virus associated T-cell neoplasias, in contrast to the T-cell acute lymphocytic leukemia cell lines, expressed both DR antigens and DRo. mRNA; the HpaII sites within the BgIII fragment of DRo DNA of these human T-cell leukemia-lymphoma virus-positive T-cell lines were in all cases at least partially unmethylated. Uncultured peripheral blood T-cells from human T-cell leukemia-lymphoma virus-infected individuals expressed DR antigens at a low level,
The Hepatoprotective Eﬀect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats

Background: Mercury has a variety of industrial applications and is well-known for its hematotoxic, hepatotoxic, neurotoxic, nephrotoxic, and genotoxic eﬀects. Objectives: This study was carried out to assess the protective eﬀects of gallic acid against mercuric chloride-induced oxidative stress in albino rats. Methods: A total of 35 male Wistar rats were divided into 5 groups (7 rats per group). Groups 1 and 2 were used as the negative and positive controls, respectively and received normal saline (2 mL/kg/day, po) and mercuric chloride (0.4 mg/kg/day, po) for 28 days. Group3onlyreceivedgallicacid(200mg/kg/day,po)for28days,whereasgroups4and5receivedgallicacid(50and200mg/kg/day, respectively) after 1 hour, followed by mercuric chloride (0.4 mg/kg/day, po) for 28 days. Results: Theresultsdemonstratedthattreatmentwithgallicacidsigniﬁcantlydiminishedthemercuricchloride-inducedincrease in the serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lipid peroxidation in liver tissues. Inaddition,gallicacidtreatmentincreasedthelevelof glutathioneperoxidase,superoxidedismutase,andcatalaseactivity andloweredtheglutathionelevelinlivertissues,comparedtothemercuricchloridegroup. Theliverof rats,treatedwithmercuric chloride,showeddegeneratedcells(withmildcytoplasmicvacuolationandblebbing),binucleatedcells,andsigniﬁcantsinusoidal dilation. Conclusions: It can be concluded that gallic acid restores the activities of antioxidant enzymes and tissue markers in mercuric chloride-treated rats, probably by scavenging free radicals and improving the antioxidant defense mechanisms.
Geometric contribution to the measurement of thermoelectric power and Nernst coefficient in a strong magnetic field

For the measurement of thermoelectric power and Nernst coefficient, we used two kinds of shapes for a sample. One is the "bridge shape" and the other is, we call, "fat-bridge shape". The latter has 5 times wider main body than the former. We used pure n-InSb in this experiment, whose carrier concentration measured at 77 K was 6.6/spl times/10/sup -14/ cm/sup -3/. The length of sample is 17 mm and the temperature difference induced between the edges in that direction was about 10/spl deg/C or 100/spl deg/C near the room temperature range of 0 to 100/spl deg/C. Magnetic induction added in the perpendicular direction to the temperature gradient was in the range of 0 up to 4 Tesla. In the case of "fat bridge shape", we detected about 10% smaller Nernst coefficient and 1 to 10% smaller thermoelectric power comparing to the "bridge shape". We suppose this phenomena is due to the geometric contribution on the different shape of samples.
OTT_A_256989 2867..2878

1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Colorectal Surgery, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Background/Aims: Long non-coding ribonucleic acids (lncRNAs) are involved in the progression of cancers and affect the response to radiation therapy. This study was to investigate the mechanism of lncRNA EGOT in the radiosensitivity of rectal cancer. Methods: The mRNA expression of EGOT, miR-211-5p and ErbB4 in rectal cancer tissues and cells was detected by qRT-PCR. The protein expression of ErbB4 was detected by Western blot. Dual-luciferase reporter assay and ribonucleic acid immunoprecipitation (RIP) were used to confirm the interaction between EGOT and miR-211-5p or miR-211-5p and ErbB4. Transfection technology was used to down-regulate and up-regulate the expression of EGOT and miR-211-5p in rectal cancer cells, respectively. MTT, colony formation and flow cytometry were used to detect the effect of EGOT and miR-211-5p on proliferation, invasion, migration and apoptosis of rectal cancer cells. Results: The expression of EGOT was up-regulated in rectal cancer tissues and cells, and the expression of EGOT was related to the late stage of pathology. EGOT knockdown inhibited the proliferation and colony formation of rectal cancer cells and induced the apoptosis of rectal cancer cells. Moreover, EGOT knockdown was significantly enhanced the effects of radiotherapy on rectal cancer in vivo and in vitro. Furthermore, EGOT was found to serve as a sponge of miR-211-5p, and ErbB4 was a downstream target of miR-211-5p. EGOT enhanced the expression of ErbB4 by regulating miR-211-5p. MiR-211-5p inhibitor restored the effect of EGOT knockdown on the radiosensitivity of rectal cancer. Conclusion: Down-regulation of EGOT could inhibit the growth of rectal cancer cells by regulating the miR-211-5p/ErbB4 axis and improve the radiosensitivity of rectal cancer cells. EGOT may be a new therapeutic target for rectal cancer.
Nearly Kaehler geometry and Riemannian foliations

We consider strict and complete nearly Kaehler manifolds with the canonical Hermitian connection. The holonomy representation of the canonical Hermitian connection is studied. We show that a strict and complete nearly Kaehler is locally a Riemannian product of homogenous nearly Kaehler spaces, twistor spaces over quaternionic Kaehler manifolds and 6-dimensional nearly Kaehler manifolds. As an application we obtain structure results for totally geodesic Riemannian foliations admitting a compatible Kaehler structure. Finally, we obtain a classification result for the homogenous case, reducing a conjecture of Wolf and Gray to its 6-dimensional form.
MINIREVIEW Microcompartments in Prokaryotes: Carboxysomes and Related Polyhedra

All cyanobacteria and many chemoautotrophs contain polyhedral inclusion bodies that are bound by a unilamellar protein shell (15, 63). Isolation and enzymatic analysis of the bodies from Halothiobacillus neapolitanus (previously Thiobacillus neapolitanus ) revealed that they are ﬁlled with ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO); therefore they were given the name “carboxysomes” (59). Subsequent studies of both cyanobacteria and chemoautotrophic bacteria have led to the well-accepted conclusion that the “organelles” or microcompartments function to enhance the catalytic properties of the RuBisCO they contain, although the mechanism of this catalytic enhancement is unclear (51, 65). Localization and characterization of the genes encoding carboxysome components has underscored the apparent common function of these bodies in carboxysome-containing autotrophic polypeptides. Rooting was done arbitrarily using the conserved region of H. neapolitanus csoS1A , which codes for a polypeptide component of the carboxysome shell, which has greater than 90% similarity/identity to each of the known CsoS1 polypeptide regions. Several Synechococcus and Prochlorococcus species seem to group out near H. neapolitanus as well. Respective cyanobacterial and enteric CsoS1 homologs each seem to group together into respective major branches, with conserved protein clusters implying similarity of function and/or origin. The data for each bootstrap value were resampled 1,000 times, with the evolutionary distance scale (in the upper left-hand corner) horizontally representing the number of ﬁxed substitutions per site. Sequence alignment was performed with ClustalW 1.8 (70), and phylogenetic trees were constructed with Treecon (72, 73).
Scattering amplitudes in gauge theories with and without supersymmetry

This thesis aims at providing better understanding of the perturbative expansion of gauge theories with and without supersymmetry. At tree level, the BCFW recursion relations are analyzed with respect to their validity for general off-shell objects in Yang-Mills theory, which is a significant step away from their established zone of applicability. Unphysical poles constitute a new potential problem in addition to the boundary behavior issue, common to the on-shell case as well. For an infinite family of massive fermion currents, both obstacles are shown to be avoided under the certain conditions, which provides a natural recursion relation. At one loop, scattering amplitudes can be calculated from unitarity cuts through their expansion into known scalar integrals with free coefficients. A powerful method to obtain these coefficients, namely spinor integration, is discussed and rederived in a somewhat novel form. It is then used to compute analytically the infinite series of one-loop gluon amplitudes in N = 1 super-Yang-Mills theory with exactly three negative helicities. The final part of this thesis concerns the intriguing relationship between gluon and graviton scattering amplitudes, which involves a beautiful duality between the color and kinematic content of gauge theories. This BCJ duality is extended to include particles in the fundamental representation of the gauge group, which is shown to relieve the restriction of the BCJ construction to factorizable gravities and thus give access to amplitudes in generic (super-)gravity theories.
Aeromechanic and Aeroacoustic Predictions of the Boeing SMART Rotor Using Coupled CFD/CSD Analysis

A computational study has been done on the Boeing Active Flap SMART Rotor using the computational tools developed at Georgia Institute of Technology, The Pennsylvania State University, and Northern Arizona University under the DARPA Helicopter Quieting Program. These tools included modifications to the Computational Fluid Dynamics code OVERFLOW for elastic rotors, higher order numerical schemes, advanced turubulence models, and acoustics. Further additions to the solver have been made at Georgia Tech and AFDD to model the SMART rotor. The multibody finite element tool DYMORE is used to compute the structural dynamics of the SMART rotor. The DYMORE model for the SMART rotor models the flap as an elastic rotor with its own lifting line and is connected to the main rotor by elastic connetors. OVERFLOW and DYMORE are coupled using modified FSI formated files. The Ffowcs Williams–Hawkings acoustic analogy solver PSU-WOPWOP is used to compute the rotor noise using on blade and off blade acoustic data surfaces. Computed and experimental structural loads are compared for a zero flap actuation and 3P flap actuation case in moderate speed cruise flight. Acoustic calculations for these cases showed good overall correlation of the negative pressure peak but an over prediction of the positive pressure between blade passages using nonrotating permeable acoustic data surfaces. Acoustic reflections were not accounted for and expected to improve predictions.
Quality attributes of four species of bamboo shoot harvested at different stages

Bamboos are grown mainly in the deciduous and tropical evergreen areas of Asia, Africa, Caribbean and Latin America. They are one of the most important resources on the earth and regarded one of the best food items among the people all over the world. Bamboos are characterized by woody and mostly hollow culms. Presence of high amount of dietary fibre, amino acids, proteins, carbohydrates, vitamins, minerals and low fat content in bamboo shoots have made it attractive to many people for consumption. Assessment of the physical status of four edible bamboo shoots (with and without sheath) harvested at different stages was performed. It was observed that the edible portion decreased with ageing while the shoot weight, tip and base diameter, and peel percentage were increased.
Amiloride Inhibition of (cid:1) -Aminobutyric Acid A Receptors Depends upon the (cid:2) Subunit Subtype

(cid:1) -Aminobutyric acid A (GABA A ) receptors (GABARs) are respon- sible for most fast inhibitory neurotransmission in the mammalian brain. The GABARs contain several allosteric modulatory sites, many of which are useful clinically. The activity of most of these modulators depends upon the subunit composition of the receptor. The diuretic amiloride was previously reported to inhibit GABARs in frog sensory neurons. We measured its effects on recombinant GABARs to determine its mechanism of action at mammalian receptors and to examine the effect of subunit composition. Amiloride acted primarily as a competitive antagonist, reducing the sensitivity of the receptor to GABA without affecting the maximal current amplitude. Receptors containing an (cid:2) 6 subunit were about 10-fold more sensitive to amiloride than those containing other (cid:2) subunits. In contrast, the identity of the (cid:3) or (cid:1) subtype had little effect on amiloride sensitivity. Although several other modulators have specific effects at (cid:2) 6-containing receptors, amiloride is the first inhibitor to be reported with no additional dependence on the identity of the (cid:3) or (cid:1) subunit. Therefore, it probably represents a unique modulatory site on the GABAR, which could be useful for developing drugs targeting these receptors. The selective activity of amiloride could also be helpful for isolating the contri- bution of receptors composed of (cid:2) 6 subtypes in heterogeneous native GABAR populations.
University of Birmingham Realising the Business Case for Diversity: A Realist Perspective on the British National Health Service

This article takes a novel approach to exploring the business case for diversity (BCD) as it has been adopted in the British National Health Service (NHS), principally in terms of ‘race’ and ethnicity for the sake of clarity and manageability. It draws on realist perspectives that consider issues of context, mechanism and outcome. It concludes that transferring policies from other countries and sectors is problematic, and consequently that the application of the BCD to the NHS must be treated with extreme caution. If you speak to the ﬁnance director, emphasise the pure business case. If it is the public health representative then emphasise the impact on health inequalities. If you are speaking to frontline staff delivering the service, then emphasise making a difference to the way care is delivered; there is a business case for workforce diversity, but it is sold to different people in different ways. (Interview NHS
An intuitionistic fuzzy estimation of the area of 2D–ﬁgures

: An iterative procedure is proposed, starting from an initial grid-step and ending up with a smaller grid-step – small enough to be able to build the square hull for the given iteration. We propose in this paper also a formula for intuitionistic fuzzy estimation for the area surrounded by a continuous simple closed curve in the real 2D space. Therefore, this is a numerical method allowing to program the algorithm in any procedural language. The iterative process stops when a small enough limit between the upper and lower estimation has been reached.
Compressible vortex rings and their interaction with stationary surfaces

Experimental studies have been conducted on the topic of the interaction of compressiblevortex rings on stationary surfaces. Throughout the campaign experimentswere carried out at pressure ratios of ! 4, 8, and 12. In the classical set up of airas both the driver and driven gas, these corresponded to theoretical incident Machnumbers Ms of 1.34, 1.54, and 1.61. Experiments were conducted on vortex rings impinging on a stationary surfacelocated at three (increasing) distances (1.66, 3.33, and 5.00 inner diameters) fromthe shock tube exit and on a stationary surface at a set distance but at three anglesinclinations (75, 60, and 45deg at 3.33 inner diameters). Results of the impingementof a vortex ring on a stationary solid surface perpendicular to the flow showed asymmetrical impingement process. A boundary layer is generated over the surfacewith an associated increase in pressure. An increase in velocity due to the radialexpansion causes the pressure over the surface to decrease. This expansion leads tothe development of azimuthal wave instabilities along the core. Pressure was seen toincrease with an increase in incident Mach number value. The variation in distanceresulted in an increase in pressure with an increase in distance. This counter-intuitiveresult can be explained by the higher translational velocity at impingement, alongwith the absence of the initial radial expansion of the counter-rotating vortex rings.The variation in surface angle inclination introduced several degrees of asymmetry.One core of the vortex ring impinges first on the surface due to its closerproximity to it, while the other core is still free to propagate. This process generatesan asymmetric boundary layer over the surface, and a higher rate of stretching ofthe lower core, resulting in its dissipation. At higher incident Mach numbers, theembedded rearward facing shock is reflected and propagates perpendicularly to thesurface. At the inclination angles of 60 and 45deg, the counter-rotating vortex ringsare fully deflected upwards and orbit around the main vortex. This phenomenonresult in a significant difference in pressure distribution between the upper and lowersections of the surface.
Antimicrobial Resistance and Virulence Profiles of Enterococcus spp. isolated from Horses and Horse-associated Environments in Korea

Antimicrobial resistant (AR) Enterococci have emerged as leading nosocomial pathogens. Transmission of AR Enterococci from animals to humans was demonstrated. However, limited information is available for Enterococci from horses. The goal of this study was to characterize Enterococci isolated from horse-associated-samples for their AR profiles and virulence traits. From 3,078 horsed-associated-samples, 264 Enterococci were isolated in Korea during 2013. AR profiling revealed that the average ratio of AR Enterococci was 54.2 %. Seven isolates (2.7 %) were defined as multi-drug resistant E. faecalis . Most of tetracycline resistant Enterococci harbored either of tetM or tetL , or both. The detection rates of other AR genes in Enterococci resistant to other kinds of antimicrobials were relatively low. Biofilm formation and gelatinase activities were observed in 50.8 % and 47.3 % of Enterococci, respectively. Most of them were E. faecalis carrying gelE gene. Pulsed filed gel electrophoresis analysis indicated transmission of AR Enterococci between horses and their environments. These results might suggest a possibility of transmission of horse AR Enterococci to horse-riders and horse-care-workers by close contacts.
(2018). Computing JSJ decompositions of hyperbolic groups. (2),

We present an algorithm that computes Bowditch’s canonical JSJ decomposition of a given one-ended hyperbolic group over its virtually cyclic subgroups. The algorithm works by identifying topological features in the boundary of the group. As a corollary we also show how to compute the JSJ decomposition of such a group over its virtually cyclic subgroups with inﬁnite centre. We also give a new algorithm that determines whether or not a given one-ended hyperbolic group is virtually fuchsian. Our approach uses only the geometry of large balls in the Cayley graph and avoids Makanin’s algorithm.