Miracle-dz/UniFAR-FTUs huggingface dataset:
Improved Epilepsy and Speech Outcomes with Human Embryonic Stem Cell Therapy in Children with Cerebral Palsy

Title: Improved Epilepsy and Speech Outcomes with Human Embryonic Stem Cell Therapy in Children with Cerebral Palsy Introduction: CP is a group of permanent neurological disorders which is prevalent in children of neonatal age and is often associated with epilepsy and speech disorders. The various conventional treatments and therapies available so far are unable to treat these comorbidities. In this study, we aimed to evaluate 101 patients with CP having speech disorders and epilepsy. The patients were treated using hESC therapy and assessed by Gross Motor Function Classification System - Expanded and Revised (GMFCS – E & R) score. Materials and Methods: Patients were given hESCs via different routes of administration for duration of 8 weeks and evaluated before and after the treatment on the basis of their le
Differences In Risk Factors And Mortality, In Young And Old Individuals With Acute Myocardial Infarction In Goa

Background: Coronary Heart Disease (CHD) is a major cause of mortality and is a global health problem. Aims: There could be a difference in the risk factors in the young and the old individuals with Acute Myocardial Infarction (AMI), and the information about these may have an influence on the strategies for preventive cardiology. In this study, we tried to investigate the same. Settings and design: Retrospective record based study done in a government medical college. Methods and materials: Records of patients with AMI admitted from January 1 to December 31, 2005 were investigated retrospectively. A total of 355 patients admitted to the Department of Medicine with AMI, were analysed. Characteristics of the patients who were ≤ 45 years of age and were considered young were compared with those above 45 years. Statistical analysis used: SPSS software. Results: 22.25% (79) of those admitted with AMI were ≤ of 45 years. 11.39% (9) of the AMI in young individuals, occurred in females, compared to 27.69% (77) in the old AMI patients. 21.51% (17) of the young AMIs presented with cardiac failure (CF) compared to 41.30% (114) in the older age group. Risk factors like alcohol and smoking were more commonly found in the young AMIs, whereas diabetes mellitus (DM), hypertension (HT) and past history of Ischaemic Heart Disease (IHD) and AMI were higher in the older patients. 10.12% (8) of the young AMIs died, as compared to 27.53% (76) in the older population. Conclusions: Preventive measures for AMIs in the younger age group should involve measures to prevent smoking and alcohol consumption. Preventive measures in the elderly patients should emphasise on control of DM and HT.
An evolving anesthetic protocol fosters fast tracking in pediatric cardiac surgery: A comparison of two anesthetic techniques

Background: The past two decades have seen rapid development of new surgical techniques for repair as well as palliation of complex congenital heart diseases. For a better patient outcome, minimal postoperative ventilation remains one of the most important endpoints of an effectual perioperative management. Aims and Objectives: The aim of this randomized open-label trial was to compare postoperative extubation time and intensive care unit (ICU) stay when two different anesthetic regimens, comprising of induction with ketamine and low-dose fentanyl versus high-dose fentanyl, are used, in pediatric patients undergoing corrective/palliative surgery. Materials and Methods: Patients with congenital cardiac defects, under 14 years of age undergoing cardiac surgery under cardiopulmonary bypass (CPB) and epidural analgesia, were enrolled into two groups – Group K (ketamine with low-dose fentanyl) and Group F (high-dose fentanyl) – over a period of 10 months, starting from January 2018. The effect of both these drugs on postoperative extubation time and ICU stay was compared using Mann–Whitney U-test. Results: A total of 70 patients were assessed with equal distribution in both the groups. In Group K, 32 of 35 patients were extubated in the operation room, whereas extubation time in Group F was18.1 ± 11 h. Total ICU stay in Group K and Group F was 45.2 ± 30.1 and 60.1 ± 24.5 h, respectively (P = 0.02). Systolic blood pressure was significantly higher in Group K. Conclusion: Ketamine along with low-dose fentanyl, when used for anesthetic induction, in comparison to high-dose fentanyl, reduces postoperative extubation time and ICU stay, in pediatric patients undergoing corrective/palliative surgery under CPB and epidural analgesia for congenital cardiac defects.
INCREASED FLUID INTAKE IN PATIENTS WITH CHRONIC KIDNEY DISEASE UNDERGOING HEMODIALYSIS

Introduction: Some of the main nursing problems that arise in patients with chronic kidney failure undergoing hemodialysis are problems with excess fluid volume.The aim of this study was to describe increased fluid intake in patients with chronic kidney disease undergoing hemodialysis at Ulin General Hospital of Banjarmasin.Methods: This was a descriptive cross sectional study. 80 respondents were taken using consecutive sampling. The instruments used in this study were questionnaire of demographic, knowledge, attitude, family support, involvement of health workers and Inter-Dialytic Weight Gain (IDWG) calculation sheets.Results: The results showed that the majority of respondents were women (53.8%), the education of respondents was high school (28.8%), the average age of respondents was 48.19 years old, most respondents had been undergoing hemodialysis for less than 12 months (57.5%), the frequency of hemodialysis was 2 times each week (93.8%), the level of knowledge was good (42.5%) and moderate (42.5%), the family support was good (86.3%), the attitude was positive (55%), the involvement of health workers was good (60%), and the majority of respondents had moderate IDWG criteria (47.5%). Conclusion: Almost half of patients with chronic kidney disease who were undergoing hemodialysis at Ulin General Hospital of Banjarmasin had moderate IDWG. Further study is needed to investigate related factors of excessive fluid intake in patients undergoing hemodialysis.
Epidemiology and treatment of beta thalassemia major in China

Thalassemia, classified as the main types α‐ and β‐thalassemia, is a single gene disorder resulting from globin chain synthesis impairment through the mutation or deletion of globin genes. The incidence of thalassemia is high worldwide, with high associated mortality. Therefore, treatment is important to improve patient outcomes. This paper reviews the current status of β‐thalassemia major in China, including its epidemiology and treatment.
Avaliação da cognição e da integridade axonal do nervo óptico em pacientes com síndrome clinicamente isolada

Introducao: Estudos evidenciam o deficit cognitivo na EM, entretanto poucos sao os estudos que avaliaram de forma sistematica a cognicao em pacientes com CIS, bem como sua correlacao com aspectos neuropsiquiatricos e de qualidade de vida. Objetivos: Investigar os prejuizos cognitivos, psiquiatricos, qualidade de vida e injurias do nervo optico em pacientes com Sindrome Clinicamente Isolada, bem comocorrelacionar estas variaveis. Metodos: Este estudo e transversal, realizado numa amostra de 18 pacientes com sindrome clinicamente isolada e um grupo controle (n=18) composto por sujeitos saudaveis, pareados por genero, idade, escolaridade e dominância-mao. Pacientes e controles foram submetidos a: bateria de testes para avaliacao cognitiva, inventarios de depressao e ansiedade; protocolo de analise de incapacidade neurologica (GNDS); questionario de qualidade de vida (DEFU) e tomografia de coerencia optica (OCT) em ambos os olhos. A avaliacao da incapacidade funcional foi realizada atraves da escala expandida do estado de incapacidade (EDSS), do nivel intelectual foi feita pela Escala de Inteligencia para Adulto WAIS III (forma abreviada subtestes de vocabulario e figura) e pelo miniexame do estado mental (MEEM). Os dados continuos foram comparados utilizandose o teste de Mann-Whitney e as proporcoes foram comparadas atraves de tabelas decontingencia utilizando-se o teste Qui-quadrado e teste exato de Fischer. As correlacoes entre espessura de nervo optico, dados cognitivos, escalas de ansiedade, depressao e QoL foram analisadas com o teste de Spearman. O nivel de significância foi estabelecido em p<0,05. Resultados: Pacientes com CIS tiveram desempenho significativamente inferior nos testes PASAT 2 segundos (P=0.009) e fluencia verbal(P=0.0038) quando comparados ao grupo controle. Houve diferenca significativa na qualidade de vida (QoL) avaliada entre pacientes com CIS e controles (P=0,000). Houve diferenca no BAI (P=0,003), entretanto nao houve diferenca do BDI entre pacientes e controles. Houve correlacoes significativas entre QoL, fluencia verbal e Stroop, contudo nao verificou-se correlacao da QoL com sintomas de depressao eansiedade. A espessura do nervo optico e reduzida mais frequentemente em olhos com historia de neurite optica (NO) (85,7%) do que olhos sem historia de NO (21,7%) (P=0,0146). Nao foi encontrado correlacao entre perda axonal do nervo optico com o desempenho cognitivo. Conclusao: Pacientes com sindrome clinicamente isoladaapresentaram pior desempenho cognitivo em testes relacionados a funcoes executivas e as alteracoes cognitivas se correlacionam com diminuicao da qualidade de vida (QoL), o que nao ocorreu com a depressao, ansiedade e incapacidade neurologica. Nossos resultados corroboram que depressao e ansiedade estao presentes desde oprimeiro surto e que progridem apos a evolucao da CIS para EM. A OCT detecta perda axonal decorrente de neurite optica e perda axonal subclinica em olhos sem NO previa. Entretanto, a reducao axonal nao se correlacionou com o desempenho cognitivo na populacao estudada.
A phase Ia/Ib trial of the anti-programmed death-ligand 1 (PD-L1) human monoclonal antibody (mAb), CS1001, in patients (pts) with advanced solid tumours or lymphomas

Abstract Background CS1001 is a first full-length, fully human anti-PD-L1 mAb developed by the OMT transgenic rat platform, which mirrors natural IgG4 human antibody with expected pharmacokinetics (PK) profiles, and may potentially reduce the risk of immunogenicity and toxicity in pts. This first-in-human Phase Ia/Ib study of CS1001 was conducted to evaluate the safety, tolerability, PK profile, and anti-tumor activity of CS1001 in pts with advanced solid tumors or lymphomas. Methods Pts with advanced solid tumors or lymphomas were enrolled in the dose escalation Phase Ia, receiving CS1001, Q3W, IV, at escalating doses from 3, to 10, 20, 40 mg/kg and 1200 mg fixed dose. Dose escalation followed a 3 + 3 dose escalation scheme. Dose-limiting toxicity (DLT) was evaluated within 3 weeks after the initial dose. Pts with various tumor types were enrolled in the dose expansion Phase Ib to assess anti-tumor activity and safety, including GC, cholangiocarcinoma, NSCLC, HCC, etc. Safety was assessed by monitoring the frequency and severity of adverse events (AEs) per NCI CTCAE v4.03, tumor response was assessed per RECIST v1.1 (solid tumors) or Lugano 2014 (lymphomas). Results As of 30 Nov 2018, 29 pts, median age of 53 (23-75) years, were enrolled in Phase Ia, 3 mg/kg (N = 3); 10 mg/kg (4); 20 mg/kg (3); 40 mg/kg (3) and 1200 mg fixed dose (16). 20 pts discontinued treatment, mostly due to disease progression (14). 2 pts discontinued treatment due to AEs (Grade [G] 4 hepatic function abnormal and G3 pulmonary tuberculosis, neither of which were related to CS1001). Median treatment duration was 126 (21-408+) days. No DLTs were observed. The most frequent TRAEs included anaemia (48.3%) and proteinuria (44.8%). SAEs were reported in 6 pts and they were not related to CS1001. irAEs occurred in 7 pts. Among the 29 pts, 7 (24%) pts had PR, mDoR was not reached. In Phase Ib, 162 pts were enrolled as of 15 Mar 2019. Conclusions CS1001 is well tolerated without DLT across the dose levels investigated. Evidence of anti-tumor activities was observed. Currently, 1200 mg fixed dose Q3W is being explored in various tumor types in Phase Ib, safety and efficacy results of selected Phase Ib expansion arms will be reported at the conference presentation. Clinical trial identification NCT03312842. Legal entity responsible for the study CStone Pharmaceuticals (Su Zhou) Co., Ltd. Funding CStone Pharmaceuticals (Su Zhou) Co., Ltd. Disclosure J. Ding: Full / Part-time employment: CStone Pharmaceuticals. J. Wang: Full / Part-time employment: CStone Pharmaceuticals. Y. Wang: Full / Part-time employment: CStone Pharmaceuticals. H. Dai: Full / Part-time employment: CStone Pharmaceuticals. All other authors have declared no conflicts of interest.
Prognostic relevance of genetic variations in T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma

T-cell acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) are highly aggressive malignant tumors. With the current intensive treatment regimens, event-free survival (EFS) rates of up to 60–90% can be achieved, but the survival rate of relapsed patients remains poor—only approximately 3–12%. Therefore, precise and effective prognostic parameters are highly needed to further improve survival rates along with reduced acute and long-term toxicities, including the rate of secondary malignancies. In addition, gene mutations can be used as therapeutic targets. This review highlights several gene mutations with a high frequency or a strong influence associated with favorable or unfavorable aspects of prognosis—NOTCH1, FBXW7, PTEN, LOH6q, CASP8AP2, c-MYC, IL-7, CALM-AF10, and CDKN2A/B—and indicates that the actual incidence of mutations in T-ALL/LBL is much higher than currently recognized. The development of multicenter clinical trials and molecular genetics research aimed at understanding the biology of these diseases offers promise for targeted and more effective therapy.
Factors Related to Foot Care Behaviors Among Patients With Type 2 Diabetes Mellitus in Da Nang, Vietnam

Background: Foot ulceration and amputation have alarmingly increased among patients with type 2 diabetes mellitus in Vietnam. Poor foot care behavior is one of the crucial reasons which leads to diabetes related foot problems. Exploration factors related to foot care behaviors among people with diabetes becomes a necessary issue to limit this complication. Objective: To determine factors related to foot care behaviors among patients with type 2 diabetes mellitus. Methods: The descriptive correlation study was conducted in 140 participants by purposive sampling technique in the outpatient room of Da Nang Hospital, Da Nang, Vietnam from December 2017 to January 2018. Instrument used in the study included of the six cognitive impairment test, demographic form, the Nottingham assessment of functional foot care, foot care knowledge, foot care confidence scale, and foot care subscale in the social support scale for self-care in middle-aged patients with type 2 diabetes mellitus. Data were analyzed by chi-square test, Pearson product moment correlation coefficient, and Spearman rank correlation coefficient. Results: Of 140 participants, 58.6% had poor foot care behaviors. Education level, foot care knowledge, foot care self-efficacy, and social support showed a statistically significant positive correlation with foot care behaviors. There was no significant correlation between age, gender, and foot care behaviors. Conclusions: The study suggested that improving foot care knowledge, foot care behaviors and enhancing the role of nurses must be implemented for the improvement of foot care behaviors among patients with type 2 diabetes mellitus.
[Abdominal traumatic evisceration: reconstruction abdominal wall with biologic mesh and negative pressure therapy].

INTRODUCTION Abdominal traumatic evisceration as a result of high energy trauma is uncommon. Once repaired the possible internal damage, an abdominal wall defect of high complexity may exist, whose reconstruction represents a surgical challenge. CASE REPORT Politraumatized male with important abdominal muculocutaneous avulsion and evisceration. After initial repair, the patient developed a big eventration in which we use a porcine dermis-derived mesh (PermacolTM), a safe and effective alternative in abdominal wall repair, thanks to its seamless integration with other tissues, even when exposed. Negative pressure therapy has been used for the management of wound complications after surgical implantation of PermacolTM mesh. We describe our experience with the use of PermacolTM mesh and negative pressure therapy to aid the wound closure after skin necrosis and exposed mesh.
Relationships between Obesity, Body Image Perception, and Weight Control in Adult Women.

PURPOSE The purpose of this study was to investigate the relationship between obesity, body image perception, and weight control for obesity management in adult women. METHODS The subjects of this study were 3,617 women aged over 19 years, who participated in the Seventh Korea National Health and Nutrition Examination Survey 2016. Data were analyzed through complex sampling design data analysis. RESULTS Right body image perception according to obesity was apparent between 70.6-81.7% of women and 76.5% of women with abdominal obesity perceived that they were normal. Obese women performed more weight control than non-obese women. Women with only abdominal obesity performed less weight control than non-obese women, and 47.3% of them performed weight control. Women who perceived themselves as obese performed more weight control than women who perceived themselves as non-obese (odds ratio, 2.08; confidence interval, 1.69-2.57), but body mass index was not observed to be associated with weight control. CONCLUSIONS: Education on abdominal obesity should be provided to increase awareness about abdominal obesity and its effective management, especially in women with only abdominal obesity. In addition, interventions for right body type perception should be provided for proper weight control along with prevention and management of obesity.
Beyond the Disease Model of Mental Disorders

As known, adventure and experience about lesson, entertainment, and knowledge can be gained by only reading a book. Even it is not directly done, you can know more about this life, about the world. We offer you this proper and easy way to gain those all. We offer many book collections from fictions to science at all. One of them is this beyond the disease model of mental disorders that can be your partner.
Kiwifruit extract attenuates tadalafil induced retinal injury in adult male albino rats: a histological and immunohistochemical study

Background: Tadalafil is a one of the commonly prescribed drugs for treatment of erectile dysfunction. Several ocular side effects have been reported with tadalafil therapy. Kiwi fruit is a popular fruit that has a wide range of pharmacological activities and a proposed role in combating serious ocular complications.Aim: To evaluate the potential protective role of kiwi fruit extract (KFE) against tadalafil induced retinal injury in adult male albino rats.Material and Methods: Thirty adult male albino rats were divided into four groups; control group, KFE-treated group (500 mg/kg), Tadalafil-treated group (1.8 mg/kg), and both Tadalafil & KFE-treated group. Animals were orally administered once daily for six weeks. Specimens from the retina were processed for light and electron microscopy. Immunohistochemical study was performed using antibodies against B-cell lymphoma 2 (Bcl-2). Results: Specimens from tadalafil-treated animals showed a statistically significant decrease in the total retinal thickness and the ganglion cell number. The retinal pigmented epithelium was detached. The inner segment of the photoreceptor was irregularly oriented with interrupted outer limiting membrane. Dark pyknotic nuclei were observed in the outer and inner nuclear layers and the ganglion cell layer. Ultrastructurally, disorganized membranous discs with increased inter-disc spaces of the outer segment, cytoplasmic vacuoles and swollen mitochondria of the inner segment of the photoreceptor layer and shrunken irregular cell bodies and nuclei of the outer and inner nuclear and ganglion cell layers were observed. The immunohistochemical study showed a significant decrease in Bcl-2 immunoreaction. In contrast, minimal changes were observed in rats treated concomitantly with both tadalafil and kiwi fruit extract, with a non-significant decrease in the immunoreaction. Conclusion: Tadalafil induced structural changes in the retina of adult albino rat that could be ameliorated by concomitant treatment with kiwi fruit extract.
Survey of Gynecological problems During Childhood and Early Adolescence in an Academic Center

5 CONTENTS . 9 ABBREVIATIONS . 13 LIST OF ORIGINAL PUBLICATIONS . 14 INTRODUCTION . 15 REVIEW OF THE LITERATURE. 16 1. Interests in pediatric gynecology . 16 2. Gynecological examination of children . 19 2.1. Genital anatomy during childhood . 19 2.1. 1. Newborns . 20 2.1. 2. Infancy and childhood . 20 2.1. 3. Early puberty . 21 2.1. 4. Puberty . 21 2.2. Settings for examination . 21 2.3. Examination techniques . 22 2.4. Instruments and supplies . 23 2.5. Sonography . 24 2.5. 1. Sonographic findings in the normal ovary . 25 2.5. 2. Sonographic findings in the normal uterus . 26 3. Hormones and female sexual maturation . 28 3.1. Gonadotropin-releasing hormone and gonadotropins . 28 3.2. Estrogen and progesterone. 28 3.3. Other hormonal factors influencing pubertal development. 30 4. Vulvar and vaginal diseases during childhood . 31 4.1. Vulvovaginitis . 31 4.2. Sexually transmitted diseases . 33 4.3. Skin disorders . 34 4.3.1. Lichen sclerosus . 35 4.3.2. Other skin conditions . 36
Pattern of Rheumatic valvular involvement and its contribution towards valvular malfunction in young adults

Objective To study the different patterns of valvular malfunction in Rheumatic heart disease (RHD) and assess the factors contributing towards it. Methods This is an observational study among patients with chronic RHD. One hundred patients (female 81 and 19 males) within ages 12 to 40 years (Mean age 27.3) were analyzed. A relevant clinical history including that of an initial episode of acute rheumatic fever (ARF) and recurrent episodes was obtained. 2D echo assessment of the cardiac valves was performed with an estimation of Wilkins score for the mitral valve (MV). Results Among the study population female: male ratio was 4:1. 30% had recurrent episodes of ARF. Only 60% had at least some evidence of ARF at any time in their life. The posterior mitral valve appears to be affected more than the anterior leaflet giving an average Wilkins score of 9.7 and 6.7 respectively. The total score had a positive correlation with Mitral stenosis (MS) (p <0.05). MV involvement was noted in 97%. 44% had significant mitral valve prolapse (MVP) but no statistical correlation was noted with mitral regurgitation (MR) (p>0.05). A regurgitant grade of 2 or more was found in 41%. High sensitive C reactive protein of more than 1mg/dl was noted in 55% of patients. Conclusion Chronic rheumatic MV disease can exist as MS, MR, MVP or simply an elevated valve score. Apart from recurrent streptococcal infections and chronic sub clinical inflammation, a number of different components of valve damage contribute towards the end result.