Miracle-dz/UniFAR-FTUs huggingface dataset:
Linkage between Productive Safety Net Program and Health Services in Somali Region, Ethiopia: Lessons, Challenges and Missed Opportunities

Abstarct Background The fourth phase of Ethiopia‟s Productive Safety Net Programme (PSNP 4) included a system of integrated health and nutrition service delivery for its categories of beneficiaries. This include the creation of a temporary direct support (TDS) category for clients that are pregnant and lactating women or caregivers of malnourished children, who are exempted from public work but expected to comply with coresponsibilities which counts towards their public works requirement. This is aimed at improving utilization of health and nutrition services.
Circulating T-Cell Repertoires Correlate With the Tumor Response in Patients With Breast Cancer Receiving Neoadjuvant Chemotherapy

PURPOSE Neoadjuvant chemotherapy (NAC) has been widely used in patients with breast cancer to minish tumor burden and increase resection rate of cancer. T-cell repertoire has been believed to be able to monitor antitumor immune responses. This study aimed to explore the dynamic change of T-cell repertoire and its clinical value in evaluating the tumor response in patients with breast cancer receiving NAC. MATERIALS AND METHODS Ninety-four patients who underwent NAC before surgery were recruited, and peripheral blood samples were collected at multiple time points during NAC. High-throughput T-cell receptor (TCR)-β sequencing was used to characterize the T-cell repertoire of every sample and analyzed the changes in circulating T-cell repertoire during NAC. RESULTS We found that the diversity of TCR repertoires was associated with age and clinical stage of the patients with breast cancer. The distribution of Vβ and Jβ genes in TCR repertoires was skewed in patients with human epidermal growth factor receptor 2–positive (HER2+) breast cancer. Vβ20. 1 and Vβ30 expression levels before NAC correlate with tumor response after all cycles of NAC in HER2– and HER2+ patients, respectively. Some CDR3 motifs that correlated with clinical response in either HER2+ or HER2– patients were identified. Besides, TCR repertoire evolved during NAC and the diversity of TCR repertoire decreased more after two cycles of NAC in patients with good tumor response after all cycles of NAC (P = .0061). CONCLUSION Our results demonstrated that TCR repertoire correlated with the characteristics of the tumor, such as the expression status of HER2. Moreover, some characteristics of TCR repertoires that correlated with clinical response were identified and they might provide useful information to tailor therapeutic regimens at the early cycle of NAC. This study identified T-cell repertoires that correlated with clinical response in patients with breast cancer.
Ferroptosis‐related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma

Ferroptosis is a regulated cell death nexus linking metabolism, redox biology and diseases including cancer. The aim of the present study was to identify a ferroptosis‐related gene prognostic signature for stomach adenocarcinoma (STAD) by systematic analysis of transcriptional profiles from The Cancer Genome Atlas (TCGA), GEO and a clinical cohort from our centre. We developed a predictive model based on three ferroptosis‐related genes (CHAC1, NOX4 and HIF1A), gene expression data and corresponding clinical outcomes were obtained from the TCGA database, and the reliability of this model was verified with GSE15459 and 51 queues in our centre. ROC curve showed better predictive ability using the risk score. Immune cell enrichment analysis demonstrated that the types of immune cells and their expression levels in the high‐risk group were significantly different from those in the low‐risk group. The experimental results confirmed that NOX4 was upregulated and CHAC1 was downregulated in the STAD tissues compared with the normal stomach mucosal tissues (p < 0.05). In sum, the ferroptosis‐related gene signature can accurately predict the outcomes of patients with STAD, providing valuable insights for personalized treatment. As the signature also has relevance to the immune characteristics, it may help improve the efficacy of personalized immunotherapy.
Local Government Planning and High-Speed Broadband in Australia

Abstract The introduction of the Australian National Broadband Network (NBN) in 2009 raised questions about the potentials of the telecommunications infrastructure for Australian urban and regional planning. The recent decision by the Australian Federal Government to build the NBN, using a mix of technologies, has intensified the need to investigate the implications of telecommunications at the local level, as Australian local governments then need to respond differently based on the level of access provided in each case. The paper investigates such implications in the three areas of e-governance, socioeconomic development, and spatial planning. Building upon the international literature, and empirical data collected from the Australian local governments, it analyzes a raft of mostly unscrutinized policy initiatives developed, over the last few years, to guide the early rollout. The findings show some policy development regarding the socioeconomic implications of the new infrastructure, limited understanding of e-governance potentials, and lagging policy focus on spatial planning.
An analysis of recorded and simulated SH wave reverberations in the upper mantle beneath the USArray

Long-period (T > 10 s) shear-wave reverberations between the surface and reflecting boundaries below seismic stations are useful for studying the mantle transition zone (MTZ) but finite-frequency effects may complicate the interpretation of waveform stacks. Using waveform data from the USArray and spectral-element method synthetics for 3-D seismic models, we illustrate that a common-reflection point (CRP) modeling of layering in the upper mantle must be based on 3-D reference structures and accurate calculations of reverberation traveltimes. Our CRP mapping of recorded waveforms places the 410-km and 660-km phase boundaries about 15 km deeper beneath the western US than beneath the central-eastern US if it is based on the 1-D PREM model. The apparent east-to-west deepening of the MTZ disappears in the CRP image if we account for shear-wave velocity variations in the mantle. We also find that ray theory overpredicts the traveltime delays of the reverberations if 3-D velocity variations in the mantle are prescribed by global models S40RTS, SEMUCB-WM1, and TX2015. Undulations of the 410-km and 660-km are underestimated in the analysis when their wavelengths are smaller than the Fresnel zones of the wave reverberations in the MTZ. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Geophysical Journal International following peer review. The version record “Meichen Liu, Jeroen Ritsema, Carlos A M Chaves, Influence of shear-wave velocity heterogeneity on SH wave reverberation imaging of the mantle transition zone, Geophysical Journal International , 2022;, ggac321” is available at https://doi.org/10.1093/gji/ggac321 Influence of shear-wave velocity heterogeneity on SH wave reverberation imaging of the mantle transition zone Meichen Liu1,#, Jeroen Ritsema1, and Carlos A. M. Chaves2 1 Department of Earth and Environmental Sciences, University of Michigan, 1100 North University Avenue, Ann Arbor, MI 48109, USA. 2 Departamento de Geof́ısica, Instituto de Astronomia, Geof́ısica e Ciências Atmosféricas, Universidade de São Paulo, Rua do Matão 1226, São Paulo, São Paulo, Brasil. In original form Jan 22nd, 2022. Abbreviated title: SH wave reverberations in a heterogeneous mantle # Corresponding author: Meichen Liu (meichenl@umich.edu) PhD candidate, Department of Earth and Environmental Sciences University of Michigan
Effects of different sprint training programs with ball on explosive, high-intensity and endurance-intensive performances in male young soccer players

This study compared the effects of different sprint ball-based training programs on fitness-related performances in youth soccer players. Forty male players (age: 15.2 ± 0.6 yrs) participated in a short-term (8 weeks) randomized parallel fully controlled training study, with pre-to-post measurements. Players were randomly assigned to 3 sprint ball-based training groups: training with combined sprint (performing linear and change of direction sprints; CST), or using linear sprint (LST), or performing sprint with change of direction (CODT) and to a control group (CONT). Pre- and post-training players completed a test battery involving linear sprinting (10 and 20 m, and flying 10 m), 505 test (COD), 15 m test with ball (CODB), countermovement jump test (CMJ test) and maximal oxygen consumption (VO2max). All physical performance’ variables improved after the training intervention (all p < 0.05; ES ≥ 0.2). No main effect of groups was observed in linear sprinting, CMJ and VO2max (p > 0.05; ES < 0.2). A training group main effect was found (p < 0.0001; ES = 0.50) for COD with CODT induced better performance than LST and CONT (all p <0.0001; ES > 0.8). Also, a training group main effect (p = 0.009; ES = 0.35) was found for CODB with CODT elicited better performance than LST and CONT (all p = 0.001; ES > 0.80). Our findings suggest that ball-based training programs were more effective to improve fitness levels in youth players during the in-season period and that CODT modality was more effective to improve COD and CODB performances.
NEW RADIOCARBON DATES FROM ARCHAEOLOGICAL SITES IN PARTS OF IGBOLAND, SOUTHEASTERN NIGERIA

ABSTRACT This paper presents new results of radiocarbon (14C) ages from archaeological sites in northern Igboland. The study was designed to shed more light on early human occupation and activities in the study area based on sediments from cave and iron-smelting sites. The approach consisted of ethnographic, archaeological, palynological, and slag analyses; these were complemented with 14C dates. The technology adopted as well as the paleoenvironmental conditions that prevailed during the period of human settlement in both sites was revealed. These data, complemented by 14C dates, highlight the human behavioral and subsistence patterns within the region and are comparable to those from similar sites in southeastern Nigeria.
HIV testing behaviour and associated factors in men who have sex with men by level of urbanisation: a cross-sectional study in the Netherlands

Objectives Regular HIV testing in men who have sex with men (MSM) enables timely entry into care and reduces the likelihood of HIV transmission. We aimed to assess HIV-testing behaviour and associated factors in MSM by urbanisation of place of residence. Design Data were derived from online survey (‘Men & Sexuality’) in the Netherlands, which was mainly advertised on social media (Facebook and Instagram), dating websites, apps for MSM (Grindr and PlanetRomeo) and gay media. Primary and secondary outcome measures HIV testing was defined as recent (<1 year), not recent (≥1 year) or never. Using multinominal regression analyses, factors associated with not recent testing and never testing, compared with recent testing, were assessed among MSM living in highly (>2500 residences/km2) or non-highly (≤2500 residences/km2) urbanised areas. Participants The study sample included 3815 MSM, currently living in the Netherlands. The mean age was 36 years (SD 14.7), and 67.6% were highly educated. Results In highly urbanised areas, 11.8% was never and 19.8% was not recently HIV-tested. In non-highly urbanised areas, this was 25.2% and 19.6%. Among MSM living in highly urbanised areas, independently associated with never and not recent testing were younger age, self-identification as bisexual, fewer sex partners, never notified of HIV and no recent condomless anal intercourse. Among MSM living in non-highly urbanised areas, lower perceived HIV severity, higher perceived HIV risk and a lower proportion gay friends were associated with never and not recent testing. Among never tested MSM, those in non-highly urbanised areas preferred self-sampling/self-testing over facility-based testing; those in highly urbanised areas preferred testing at healthcare facilities. Conclusions The proportion of never tested MSM was high (25%) in non-highly urbanised areas in the Netherlands. MSM living in non-highly urbanised areas may possibly be reached with targeted approaches to increase HIV testing uptake such as self-testing/self-sampling strategies.
PASSIVITY BASED DESIGN OF SYNCHRONIZING SYSTEMS

A particular problem of controlled synchronization of nonlinear systems is considered. Minimum conditions for producing such synchronization are presented and it is shown that these conditions also provide the feedback passivity of the overall system. It is also demonstrated that the conditions of feedback passivity allow one to design an adaptive synchronizing control law which ensures global synchronization in the cases when the systems to be synchronized have dierent parameters. Additionally it is demonstrated that the approach presented for the design of synchronizing systems allows one to cope with external disturbances in order to protect the systems from loss of synchrony.
Design of Blockchain-Based Lightweight V2I Handover Authentication Protocol for VANET

Connected vehicle means providing different services, such as advanced driver-assistance systems (ADAS) from vehicles connected to the network. Vehicular ad-hoc networks (VANETs) can support vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communications to realize connected vehicle. In VANETs, secure communication must be ensured, as otherwise it can lead to traffic accidents and human injuries. Recently, many studies on V2I authentication have been conducted to guarantee the security of V2I communications. However, recent V2I authentication protocols do not consider the handover situation, and it causes unnecessary computations. As vehicles have limited computing resources, unnecessary computation can lead to overload to the vehicles. In recent years, blockchain-based VANET is an active field of research because it can provide decentralization, data integrity and transparency. Using the strength of the blockchain technology, we design a blockchain-based handover authentication protocol for VANETs. In the proposed protocol, vehicles only perform lightweight computations in handover situations for efficiency of the network. We also conduct the formal analysis such as Burrows–Abadi–Needham (BAN) logic, Real-Or-Random (ROR) oracle model, and Automated Validation of Internet Security Protocols and Applications (AVISPA) simulation to the proposed protocol. We simulate the proposed protocol using network simulator 3 (NS-3) to verify that the proposed protocol is practical. Finally, we compare the computational cost and security features of the proposed protocol with existing protocols to show that the proposed protocol is more secure and efficient.
Multiple evolutionary origins of glyphosate resistance in Lolium multiflorum

The multitude of herbicide resistance patterns that have evolved in different weed species is a remarkable example of the rapid adaptation to anthropogenic‐driven disturbance. Recently, resistance to glyphosate was identified in multiple populations of Lolium multiflorum in Oregon. We used phenotypic approaches, as well as population genomic and gene expression analyses, to determine whether known mechanisms were responsible for glyphosate resistance and whether resistance phenotypes evolved independently in different populations, and to identify potential loci contributing to resistance. We found no evidence of genetic alterations or expression changes at known target and non‐target‐site resistance mechanisms of glyphosate. Population genomic analyses indicated that resistant populations tended to have largely distinct ancestry from one another, suggesting that glyphosate resistance did not spread among populations by gene flow. Rather, resistance appears to have evolved independently on different genetic backgrounds. We also detected potential loci associated with the resistance phenotype, some of which encode proteins with potential effects on herbicide metabolism. Our results suggest that Oregon populations of L. multiflorum evolved resistance to glyphosate due to a novel mechanism. Future studies that characterize the gene or genes involved in resistance will be necessary to confirm this conclusion.
Growing up with a Chronically Ill Family Member—The Impact on and Support Needs of Young Adult Carers: A Scoping Review

This scoping review provides an overview of the impact of growing up with a chronically ill family member on young adults (18–25 years old), and their specific needs. Young adults represent an important life stage involving a transition to adulthood, during which individuals’ family situations can affect their future. We searched relevant studies following the guideline of Arskey and O’Mailley’s methodological framework and the PRISMA statement guidelines for scoping reviews in PubMed, PsychInfo and reference lists to identify articles for inclusion. Studies from 2005 to 2020 were included in this review. Of the 12 studies, six qualitative studies, five quantitative studies and one mixed method study were included. Eight studies discussed the impact, including consequences at a physical and mental level, at their personal development and future perspectives, but also positive effects, such as being capable of organizing their lives. Four studies discussed the needs of young adult carers, including emotional needs, support needs with regard to stimulating autonomy (arising from internal conflicts) and developing their own identity, and the concerned attitude of involved professionals. An unambiguous definition of the target group and further well-designed research are needed to improve clarity about the role of support, so that future professionals can adequately address the needs and wishes of young adults who grow up with an ill family member.
Understanding children’s preferences: developing ecological literacy in the village landscape

ABSTRACT Children’s experiences with nature may develop ecological literacy and enhance their psychological well-being. However, a limited understanding of how the village landscape has functional impacts on the children’s play behaviour and perceptual performances can influence ecological literacy. This study investigated children’s preferences in the village landscape stimulated by their play behaviour and knowledge, which becomes a basis for ecological literacy. Seventy-one responses from middle-aged children were elicited using drawings and go-along methods. Data were analysed using NVivo 12 Plus for content analysis. The results revealed that children who preferred being outdoors were associated with play activities, which directly influenced ecological literacy. The findings showed that the children were related to the wilderness, interspecific relations with animals and plants, physical work, recreation and socialising, rurality and natural beauty. The children expressed a strong affiliation to their everyday environment in which the village landscape became a milieu for ecological literacy.
Transformation from Planning to Operations: Emergency Medical Services in Disaster Response

The preparedness for response to the medical consequences of a natural or technological event is an integral part of a comprehensive disaster response plan. Historically, planning and preparedness have lacked specific products and measurable objectives to determine if a jurisdiction was ready to respond. The development and implementation of measurable objectives and implementation of those objectives in the planning process is a critical breakthrough in disaster planning. California subscribes to an “all-hazard” planning approach and uses operational planning that will work in multiple environments. The response profile for medical care in a disaster has been shown to be required within 8 hours in the situation where mass casualties are present. Two specific strategies should be employed to prepare for the medical response to disaster events. First, EMS systems should be strengthened and, second, measurable benchmarks for disaster response should be established. The current trend is a transformation from “preparedness” to “products”, and “planning” to “operations”. The State continues to emphasize a Standardized Emergency Management System, using the principles of the Incident Command System, to achieve multi-organizational planning efforts as part of a State response plan. The foundation of medical disaster response is built on a strong “day-to-day” EMS system, using the basic components of an EMS System. Since disaster structures are unable to effectively form and respond within a short response profile, the ambulance system and emergency departments should be robust and able to increase their capabilities and capacities quickly. This recognition that the medical response is time dependent has led to specific plans to obtain rapid mobile, medical response within a time-phased deployment. These plans include benchmarks and measurable objectives related to EMS and Ambulance Strike Teams, Disaster Medical Assistance Teams, Hospital Surge capacity, communications, training, and exercises. These specific objectives form the benchmarks for evaluation of the medical preparedness for EMS and hospitals. (Ann Disaster Med. 2004;3:11-26)
The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line

Bone is a dynamic organ that can adapt its structure to meet the demands of its biochemical and biophysical environment. Osteocytes form a sensory network throughout the tissue and orchestrate tissue adaptation via the release of soluble factors such as a sclerostin. Osteocyte physiology has traditionally been challenging to investigate due to the uniquely mineralized extracellular matrix (ECM) of bone leading to the development of osteocyte cell lines. Importantly, the most widely researched and utilized osteocyte cell line: the MLO-Y4, is limited by its inability to express sclerostin (Sost gene) in typical in-vitro culture. We theorised that culture in an environment closer to the in vivo osteocyte environment could impact on Sost expression. Therefore, this study investigated the role of composition and dimensionality in directing Sost expression in MLO-Y4 cells using collagen-based ECM analogues. A significant outcome of this study is that MLO-Y4 cells, when cultured on a hydroxyapatite (HA)-containing two-dimensional (2D) film analogue, expressed Sost. Moreover, three-dimensional (3D) culture within HA-containing collagen scaffolds significantly enhanced Sost expression, demonstrating the impact of ECM composition and dimensionality on MLO-Y4 behaviour. Importantly, in this bone mimetic ECM environment, Sost expression was found to be comparable to physiological levels. Lastly, MLO-Y4 cells cultured in these novel conditions responded accordingly to fluid flow stimulation with a decrease in expression. This study therefore presents a novel culture system for the MLO-Y4 osteocyte cell line, ensuring the expression of an important osteocyte specific gene, Sost, overcoming a major limitation of this model.