Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypercapnia Causes Injury of the Cerebral Cortex and Cognitive Deficits in Newborn Piglets

In critically ill newborns, exposure to hypercapnia (HC) is common and often accepted in neonatal intensive care units to prevent severe lung injury. However, as a “safe” range of arterial partial pressure of carbon dioxide levels in neonates has not been established, the potential impact of HC on the neurodevelopmental outcomes in these newborns remains a matter of concern. Here, in a newborn Yorkshire piglet model of either sex, we show that acute exposure to HC induced persistent cortical neuronal injury, associated cognitive and learning deficits, and long-term suppression of cortical electroencephalogram frequencies. HC induced a transient energy failure in cortical neurons, a persistent dysregulation of calcium-dependent proapoptotic signaling in the cerebral cortex, and activation of the apoptotic cascade, leading to nuclear deoxyribonucleic acid fragmentation. While neither 1 h of HC nor the rapid normalization of HC was associated with changes in cortical bioenergetics, rapid resuscitation resulted in a delayed onset of synaptosomal membrane lipid peroxidation, suggesting a dissociation between energy failure and the occurrence of synaptosomal lipid peroxidation. Even short durations of HC triggered biochemical responses at the subcellular level of the cortical neurons resulting in altered cortical activity and impaired neurobehavior. The deleterious effects of HC on the developing brain should be carefully considered as crucial elements of clinical decisions in the neonatal intensive care unit.
IPv4 vs IPv6 Anycast Catchment: a Root DNS Study

Anycast has been extensively used by DNS Root Server operators to improve performance, resilience, and reliability. In line with the migration towards IPv6 networks, 9 out of 11 anycasted Root Servers are running on both IPv4 and IPv6 (dual-stack mode) today. Ideally, both protocols should provide similar performances. Problem arises since operators may have different peering policies for IPv4 and IPv6 networks, which leads to different catchment areas for the same service and potentially different quality of service. In this thesis, we analyze the IPv4 and IPv6 catchments of anycasted Root Servers from control-plane perspective between February 2008 to June 2016 using BGP data from RIPE RIS. We study the evolution and the differences of the catchment areas over the time. We also develop visualization tool to help operator assess their catchment areas. While we specifically study DNS Root Server, our methodology can be applied to other anycast services as well.
Flow diverter stents for endovascular treatment of aneurysms: a comparative study of efficacy and safety between FREDX and FRED.

BACKGROUND The FRED X flow diverter (FREDX), as the second generation in the FRED series, aims to improve the treatment of cerebral aneurysms. This study compares the efficacy and safety of FREDX with its predecessor, FRED. METHODS This prospective registry included patients treated with FRED and FREDX devices. Efficacy was assessed using digital subtraction angiography with 3D volumetric reconstruction at immediate and 1 year follow-ups. Safety was evaluated by recording complications, analyzed through univariate contrasts, generalized mixed models, and Bayesian network analyses. RESULTS We treated 287 patients with 385 aneurysms, with 77.9% receiving FRED and 22.1% FREDX. The median age was 55 years (IQR 47-65) and 78.4% were women. The FREDX group showed a higher prevalence of saccular-like aneurysms (70.6% vs 52.7%, P=0.012) and a higher rate of complete occlusion compared with FRED interventions (79.4% vs 59.3%, P=0.022). After adjusting for confounders, these differences represented a 3.04-fold increased likelihood (95% CI 1.44 to 6.41, P=0.003) of achieving complete occlusion at 1 year with FREDX interventions. Regarding safety, two (3.5%) complications (both non-symptomatic) were observed in the FREDX group and 23 (10.4%) in the FRED group (P=0.166). Bayesian network analysis suggested a trend towards fewer complications for FREDX, with a median reduction of 5.5% in the posterior distribution of the prevalence of complications compared with FRED interventions. CONCLUSIONS The FREDX device shows improved complete occlusion rates at 1 year compared with the FRED device while maintaining a favourable safety profile, indicating its potential advantage in the treatment of cerebral aneurysms.
Effects of CALL-mediated TBLT on motivation for L2 reading

Abstract Task-based language teaching (TBLT) has been drawing researchers’ and practitioners’ interest since its early onset in the 1980s. In a task-based approach, students learn language by doing interesting, relevant, and hands-on pedagogic tasks that raise their interest and keep their involvement. The rich and still developing literature on TBLT is helping to evolve both its theoretical conceptualization and practical implementation in foreign and second language education. Likewise, computer-assisted language learning (CALL) has developed as a field, with the use and integration of technology in the classroom continuing to increase and will continue to play a key role in this maturation process. The present study, hence, reports on an empirical study that investigated the effectiveness of CALL-mediated TBLT on the motivation of Iranian university non-English major EFL students. A significant effect was found for CALL-mediated TBLT (F = 267.932, p = .000, partial eta squared = .770), suggesting CALL-mediated TBLT had a positive effect on the motivation of the students in the experimental group on the posttest. Results of this study have both theoretical and practical implications and might shed light on the gap between the potentials and affordances of CALL-mediated TBLT.
Aboriginal and Torres Strait Islander health services report, 2010 - 11: OATSIH Services Reporting - key results

OATSIH services reporting—key results This is the third national report on health services provided by Aboriginal community controlled and non-community controlled health organisations, and funded by the Office for Aboriginal and Torres Strait Islander Health. In 2010–11: – primary health care services provided 2.5 million episodes of care to about 428,000 Aboriginal and Torres Strait Islander clients, a 4% increase from 2009–10 – substance use services provided treatment and assistance to about 28,600 clients, a 9% increase from 2009–10 – Bringing Them Home and Link Up counselling services were accessed by about 11,800 clients, an increase of about 10% from 2009–10.
Comparison of the ED50 of prophylactic butorphanol in preventing morphine-induced pruritus with or without palonosetron: a prospective, double-blinded, randomized dose–response trial using an up-down sequential allocation method

Abstract Background Butorphanol has been used to reduce the incidence and severity of neuraxial morphine-induced pruritus. Palonosetron is a commonly used antiemetic for the prevention of postoperative nausea and vomiting. The aim of our study was to compare the effective dose in 50% of subjects (ED50) of intravenous butorphanol infusion with or without a single intravenous bolus of palonosetron for preventing pruritus induced by epidural administration of morphine. Methods A total of 120 parturients were randomly assigned to receive an intravenous bolus injection of palonosetron plus continuous infusion of butorphanol (Group P + B) or an intravenous bolus of saline plus continuous infusion of butorphanol (Group B) after epidural administration of morphine. The antipruritic effect was graded as satisfactory (numerical rating scale (NRS) of pruritus ≤3) or unsatisfactory (NRS >3) within 48 h after morphine treatment. The first patient in each group received butorphanol infusion at a rate of 4 µg/kg/h. The infusion dose for each subsequent patient in the corresponding group was increased by 0.2 µg/kg/h after an unsatisfactory response or decreased by 0.2 µg/kg/h after a satisfactory response. The ED50 was calculated for each group and compared using up-down sequential analysis. Results The ED50 (mean [95% confidence interval (CI)]) of the dose of intravenous butorphanol infusion for preventing moderate to severe pruritus was lower in Group P + B (3.29 µg/kg/min [3.25–3.34 µg/kg/min]) than in Group B (3.57 µg/kg/min [3.47–3.67 µg/kg/min]) (p < 0.05). Conclusions Under the conditions of the present study, a prophylactic use of 0.25 mg palonosetron reduced the ED50 of prophylactic infusion of butorphanol by approximately 8% to achieve a satisfactory antipruritic effect after epidural morphine for post-caesarean analgesia.
Toxicological effects of dimethlybenzeneanthracene in Balb C mice and pharmacological intervention by silk sericin–conjugated silver nanoparticles

Polycyclic aromatic hydrocarbons (PAHs) such as 7, 12-dimethylbenzneanthracene (DMBA), due to long-term bioaccumulation cause serious physiological processes and behavioral dysfunctions such as cancer, ageing, and hypertension. Silk sericin (SS) is instrumental in cancer applications due to presence of flavonoids and carotenoids which are natural pigments, present in the layer of sericin that has antioxidant and antityrosinase activity. It reduces oxidative stress and suppresses cancer cytokines while interacting with reactive oxygen species (ROS) to stand against lipid peroxidation. Recent research was focused to calculate the pharmacological intervention of sericin-conjugated silver nanoparticles (S-AgNO3 NPs) against DMBA-induced toxicity. For this purpose, SS protein was extracted from silkworm cocoons by degumming process and the prepared S-AgNO3 NPs via a green synthesis. In female albino mice, a total of 50 mg/kg oral administration of DMBA was used for the induction of toxicity which required almost 8 to 10 weeks approximately. After 60 days of experimentation, mice were dissected, blood samples were collected for further hematological and biochemical analysis and were euthanized via cervical dislocation. There was a significant rise in the level of red blood cells, platelets, lymphocytes, and hemoglobin at the highest applied concentration of sericin and its nanoparticles. Similarly, a reasonable decline was observed in the level of white blood cells, neutrophils, eosinophils, and monocytes as compared to the cancer-inducing group. The level of glutathione, lactate dehydrogenase, and alkaline phosphatase as well as immunoglobulins such as immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) were significantly reduced in all treatment groups as compared to the DMBA-induced group. Substantial effects were demonstrated in response to S-AgNO3 NPs II (T) at the highest concentrations (200 mg/kg, BW) as follows: glutathione (2.42 ± 0.26 μmol/L), lactate dehydrogenase (493.6 ± 5.78 U/L), alkaline phosphatase (158.4 ± 6.35 U/L), IgA (4.22 ± 0.19 g/L), IgG (70 ± 1.70 g/L), and IgM (4.76 ± 0.12). The histopathological study of the liver, kidneys, and brain revealed that the DMBA-induced group showed cytotoxic effects against all selected organs of mice that were recovered by treatment of selective compounds but highly effective recovery was seen in S-AgNO3 NPs II (T). These results concluded that silk S-AgNO3 NPs showed significant pharmacological potential against cancer-inducing toxicity.
Rifting miocène du Domaine d'Alboran : datations de sédiments discordants sur les unités alpujarrides en extension (Sud de la Sierra Nevada, Chaîne Bétique)

Dans la Chaine Betique, au Sud de la Sierra Nevada, deux sequences sedimentaires neogenes ont ete datees grâce aux associations de foraminiferes planctoniques: des marnes qui revelent des âges qui vont du Langhien superieur au Serravallien superieur reposent en on-lap sur des conglomerats d'âge Langhien basal. Ces sediments se sont deposes lors du fonctionnement de failles normales a faible angle appartenant a deux systemes d'accidents fragiles en extension, a mouvement vers le Nord (systeme de Contraviesa, d'âge langhien) et vers le SW (systeme de Filabres, d'âge serravallien). Ces failles separent les unites alpujarrides et malaguides et ont contribue au «rifting» du Domaine d'Alboran
Landscape experience and migration : superdiversity and the significance of urban public open space

This thesis examines how first generation migrants experience urban outdoor places, detailing significant findings and methodological development relating to two research projects. The research is located in Sheffield, England. The first research project (Viewfinder) focuses on young refugees and asylum seekers exploring citywide greenspaces and parks. The second project (Walking Voices) addresses a neighbourhood scale of interest, working with first generation migrant residents to communicate their own stories and experiences of their local area. Creative and participatory research methods were developed for on-site work, using photography and independent audio recording. The research found that spending time outside is an important means by which first generation migrants feel a sense of agency and belonging in a neighbourhood context. Though the research supports use of urban greenspace as beneficial to individual and collective wellbeing, it underlines the critical importance of understanding cultural dimensions – motivations and barriers - to visiting parks and other types of greenspace. Evaluation of a local environment is often shaped by migrants’ experiences of past places, and previous expectations of life in the UK. Place attachment is strengthened by participation and familiarity in a local located community, and often by recognising transcultural connections. The overlapping use of public space by people from different ethnic communities offers opportunities for gradual informal contact and gives a visual shared recognition to the diversity of a neighbourhood. However, the ability to make choices about when to engage with one’s own ethnic group, and when to retreat from the expectations of this ‘public gaze’ was also valued. The thesis examines the implications of these findings for landscape architecture practice, and emphasises that the profession needs to become more culturally literate in responding to the superdiversity of urban contexts, and to difference in social and cultural values with regard to recreation, socialising, and natural places.
SOCS3, Transcriptionally Activated by NR4A1, Induces Apoptosis and Extracellular Matrix Degradation of Vaginal Fibroblasts in Pelvic Organ Prolapse

Background: Pelvic organ prolapse (POP) is a common gynecological chronic disorder. Human vaginal fibroblasts (HVFs) that maintain the integrity of vaginal wall tissues are essential for keeping pelvic organs in place. Apoptosis and the degradation of the extracellular matrix in HVFs contribute to the progression of POP. The cytokine signal transduction inhibitor 3 (SOCS3) exerts significant regulatory effects on cell signal transduction pathways, thereby affecting various pathological processes. Aims: To explore the role and mechanism of SOCS3 on HVFs in the context of POP. Study Design: In vitro cell lines and human-sample study. Methods: Anterior vaginal wall tissues were obtained from POP or non- POP patients for the analysis of SOCS3 expression. HVFs were isolated from the vaginal tissues of POP patients, and SOCS3 was either overexpressed or knocked down in HVFs via lentivirus infection. Subsequently, the biological function and mechanism of SOCS3 in HVFs were investigated. Results: SOCS3 was highly expressed in the vaginal tissues of POP patients compared to non-POP patients. Functionally, the overexpression of SOCS3 suppressed cell viability while promoting cell apoptosis in HVFs. The overexpression of SOCS3 also accelerated extracellular matrix degradation (decreasing collagen I, collagen III, and elastin, and increasing MMP2 and MMP9). In terms of mechanism, NR4A1 transcriptionally activated SOCS3 by binding to its promoter. Furthermore, rescue experiments revealed that SOCS3 knockdown hindered NR4A1 overexpression-induced cell apoptosis and extracellular matrix degradation in HVFs. Conclusion: SOCS3 mediated the apoptotic and extracellular matrix degradation effects of NR4A1 on HVFs, underlining that the restraining of the SOCS3 expression may be a promising strategy for POP treatment.
Effects of omalizumab on lung function in patients with moderate-to-severe allergic asthma: a systematic review and meta-analysis

Background: With the rise of targeted treatments for asthma, treatment with omalizumab is a new option. Objectives: To assess the improvement of pulmonary function with additional omalizumab treatment in patients (⩾6 years old) with moderate-to-severe allergic asthma. Data sources and methods: Observational studies of randomized controlled trials of add-on omalizumab for the treatment of patients with moderate-to-severe allergic asthma, published from the establishment till August 2022, were retrieved from WAN FANG DATA, PubMed, CNKI, Embase, Cochrane, and Web of Science databases. Data extraction and quality evaluation were performed on the literature that met the inclusion criteria, using RevMan 5.3 to analyze the data. Results: A total of 11 randomized controlled clinical trials were included, involving a total of 3578 patients with asthma, 1856 patients in the omalizumab group, and 1722 patients in the control group. The improvement in Forced expiratory volume in 1 s as a percentage of predicted normal and Forced expiratory volume in 1 s was more pronounced in the omalizumab-treated group [MD = 3.91, 95% confidence interval (CI): 1.89–5.94, p = 0.0002; MD = 0.09, 95% CI: 0.05–0.13, p < 0.0001], while the improvement in Morning Peak expiratory flow rate was not statistically different between the two groups (MD = 3.64, 95% CI: −22.17–29.45, p = 0.78). Conclusion: Additional omalizumab treatment showed some improvement in lung function in patients with moderate-to-severe asthma. Trial registration: PROSPERO ID:CRD42022378498.
Clinicopathological comparison between PTCL‐TBX21 and PTCL‐GATA3 in Japanese patients

Abstract Aim Peripheral T‐cell lymphoma not otherwise specified (PTCL‐NOS) is a heterogeneous disease that can be classified into the PTCL‐TBX21 and PTCL‐GATA3 subtypes. Methods In this study, we compared the clinicopathological features of PTCL‐NOS in a Japanese cohort, classified using an IHC algorithm. Results One hundred patients with PTCL‐NOS were categorized as having PTCL‐TBX21 (n = 55), PTCL‐GATA3 (n = 24), or PTCL‐unclassified (n = 21). When comparing PTCL‐TBX21 and PTCL‐GATA3, PTCL‐TBX21 showed significantly lower CD4 positivity (p = 0.047), lower counts of high endothelial venules (p = 0.032), and a tendency for a better response to initial treatment (p = 0.088). Gene expression analysis using the nCounter system showed higher expression of tumor immunity‐related genes, such as PD‐L1, LAG3, and IDO1, in PTCL‐TBX21 than in PTCL‐GATA3. PTCL‐GATA3 had significantly worse overall survival (OS) than those with PTCL‐TBX21 (p = 0.047), although a similar tendency was observed for progression‐free survival (PFS) (p = 0.064). PTCL‐GATA3 was a prognostic factor for OS in univariate analysis (HR 2.02; 95% CI, 1.09–3.77; p = 0.027), although multivariate analysis did not show significance (HR 2.07; 95% CI, 0.93–4.61; p = 0.074). In the PFS analysis, PTCL‐GATA3 was an independent prognostic factor by univariate analysis (HR 1.96; 95% CI, 1.08–3.56; p = 0.027) and multivariate analysis (HR 2.34; 95% CI, 1.07–5.11; p = 0.032). Conclusion The classification of PTCL‐NOS into PTCL‐TBX21 and PTCL‐GATA3 is useful for predicting the prognosis of Japanese patients and stratifying the administration of tumor immune checkpoint inhibitors in clinical practice.
A Young Child's Perspectives on Outdoor Play: A Case Study from Vancouver, British Columbia.

There has been an increasing amount of conce rn about the lack of direct exposure that young children have to nature and the outdoors in Canada and the United States, leading to an increase in outdoor and nature -based learning models for young children. However, very little research has been done i n the field of early childhood environmental education. In particular, studies investigating young children’s perspectives on outdoor learning and environmental education are extremely scarce. This article gives a critical summary of two previous studies that do consider young children’s perspectives in relation to environmental education, and then describes a recent case study in which one young child’s perspectives on outdoor play were sought. The findings from the three studies are compared. The impo rtance of young children’s choice in active, co constructed environmental education is discussed. As well, the need for early childhood environmental education to take place in locations that are familiar to young children is highlighted.
Urine CXCL10 as a biomarker in kidney transplantation

Purpose of review Urine CXCL10 is a promising biomarker for posttransplant renal allograft monitoring but is currently not widely used for clinical management. Recent findings Large retrospective studies and data from a prospective randomized trial as well as a prospective cohort study demonstrate that low urine CXCL10 levels are associated with a low risk of rejection and can exclude BK polyomavirus replication with high certainty. Urine CXCL10 can either be used as part of a multiparameter based risk assessment tool, or as an individual biomarker taking relevant confounders into account. A novel Luminex-based CXCL10 assay has been validated in a multicenter study, and proved to be robust, reproducible, and accurate. Summary Urine CXCL10 is a well characterized inflammation biomarker, which can be used to guide performance of surveillance biopsies. Wide implementation into clinical practice depends on the availability of inexpensive, thoroughly validated assays with approval from regulatory authorities.
Contribution to the assessment of the exposure to indoor pesticides in France

Background: Pesticides are environmental pollutants with potential health effects, but exposure of the population is badly documented. Objective: Our purpose is to assess the exposure of adults living in lle-de-France to indoor air pesticides. Methods: Two greenhouses, three florist shops and three veterinarian services were investigated. Nineteen dwellings (flats and houses) with non-occupationally exposed inhabitants were also sampled. Thirty-eight pesticides were measured in indoor air, using a MiniPartisol® air sampler (mean volume sampled: 7.1 m 3 /24 h). After extraction, samples were analysed by gas and high-performance liquid chromatographical methods (limits of quantification generally < 5 ng/m 3 ). Results and discussion: Indoor air concentrations were often near the quantification limits (mean number of different pesticides detected per sample: 3.2 ± 1.7), but maximal values reached 200-300 ng/m 3 (gardeners: malathion and methidathion, population: atrazine). The organophosphates dichlorvos, fenthion, malathion and parathion-methyl were detected in more than 10% of the samples. The organochlorines lindane, α-HCH (lindane-isomer), α-endosulfan and dieldrin were detected in 97, 38, 69 and 28% of the samples, whereas the herbicides atrazine, alachlor and trifluralin were found in 24, 21 and 14% of the samples, respectively. A specific profile, consistent with occupational activity, can be observed; on the contrary, more various pesticides were found in the dwellings, but at levels sometimes higher than in occupational places. Our results confirm previously published levels of exposure in dwellings. However, the most frequently detected pesticides can differ: the chlorpyriphos is almost undetectable in our study, contrary to the US studies.