Miracle-dz/UniFAR-FTUs huggingface dataset:
A new troglobitic species of Allochthonius (subgenus Urochthonius) (Pseudoscorpiones, Pseudotyrannochthoniidae) from Japan

Allochthonius (Urochthonius) yoshizawaisp. nov., found in Hiura-do Cave, a limestone cave located in the municipality of Kumakogen, Ehime Prefecture, Japan, is described. It can be distinguished from the consubgeneric species mainly by the carapacal chaetotaxy (6–2, 18), by the presence of 6 setae on the cheliceral palm, by the rallum with 11 blades, by the presence of 8 clavate coxal blades on coxae I, and by the decreased number and distinct shape of the chelal teeth. A redescription of the subgenus Urochthonius, and keys to the subgenera of Allochthonius and to the species and subspecies of Urochthonius are also provided, as well as some ecological remarks, a brief discussion on troglomorphisms for the subgenus, and potential threats for this species.
Attrition and Workplace Harmony of Deposit Money Banks in Rivers State , Nigeria

The study examined the relationship between attrition and workplace harmony in deposit money banks in Rivers State, Nigeria. The study adopted a cross-sectional survey research design. The target population of the study was all the 20 consolidated deposit money banks in Nigeria. However, all the banks have their regional offices in Rivers State, these regional offices constituted the accessible population for this study. There was no sampling technique. The study takes a census of the population as a sample size which constitutes one regional manager and one regional human resource manager in the 20 deposit money banks. Data for the study was collected through structured questionnaire. Inferential statistics such as the linear regression coefficient Statistics technique was used to test the hypotheses with the aid of statistical package for social science version 22.0. The results of the study showed that there was a positive and statistically significant association between attrition and workplace harmony. The study therefore recommends that deposit money banks and their human resource managers need to continually carry out manpower recruitment processes and planning to advance the attrition level in the future workforce situation in the labor market prior to recruitment of employees.
Structurally alternating copper(II) chains from oxalate andazide bridging ligands: syntheses and crystal structure of[Cu2(µ-ox)(deen)2(H2O)2(ClO4)2] and[{Cu2(µ-N3)(µ-ox)(deen)2}n][ClO4]n(deen = Et2NCH2CH2NH2)

The µ-oxalato dinuclear compound [Cu 2 (µ-ox)(deen) 2 (H 2 O) 2 (ClO 4 ) 2 ] 1 and the derived alternating µ-oxalato-µ-azido chain [{Cu 2 (µ-N 3 )(µ-ox)(deen) 2 } n ][ClO 4 ] n 2, where deen = N,N-diethylethane-1,2-diamine, have been synthesized and characterised. The crystal structures of 1 and 2 have been determined by single-crystal X-ray analysis. Their magnetic behaviour has been recorded between 300 and 4 K, showing strong antiferromagnetic coupling in each case. The data were fitted by the expression for a dinuclear copper(II) compound giving the parameters J = -300(3) cm -1 , g = 2.15(1) for 1 and J = -287(1) cm -1 , g = 2.28(1) for 2.
Tamoxifen for amyotrophic lateral sclerosis

Abstract Introduction: Amyotrophic lateral sclerosis (ALS) is the most common cause of motor neuron disease, and effective treatment for ALS is still lacking. Transactive response (TAR) -DNA-binding protein-43 (TDP-43) is aggregated in the neurons of ALS patients. Animal studies shown TDP-43 aggregation can be attenuated by enhancing autophagy by tamoxifen. However, its beneficial effects for ALS patients remain unknown. Methods: Eighteen patients with ALS without mutations in superoxide dismutase-1 (SOD-1) or fused in sarcoma (FUS) genes were randomly assigned into the tamoxifen 40 mg/day or placebo group in a double-blinded manner and all were given riluzole twice daily. Participants were followed up at 1, 3, 6, and 12 months. The primary end point was time to death or dependence on mechanical ventilation. Secondary end points were decline of the revised ALS Functional Rating Scale (ALSFRS-R) score and pulmonary function measured by forced vital capacity (FVC). Results: Ten participants were randomly assigned in the treatment group with tamoxifen, 7 finished trial, 1 reach primary endpoint; while 8 participants in the placebo group, 2 finished trial and 2 reach primary end point. The proportion of participants reaching the primary end point was lower in the tamoxifen group but did not reach statistical significance. At the 1-, 3-, and 6-month follow-up, the average decline rates of the ALSFRS-R score were slower in the tamoxifen group. No significant difference was observed in FVC and ALSFRS-R score at 12 months between groups. Conclusion: Tamoxifen exerted only a modest effect on attenuate progression for 6 months in this small trial. Additional larger scale studies should be necessary to confirm whether enhancing autophagy can attenuate ALS progression.
Assessment of lamivudine, zidovudine, lopinavir, and ritonavir plasma levels in HIV-positive pregnant women

Supplemental Digital Content is available in the text Abstract Simultaneous therapeutic drug monitoring (TDM) of combination antiretroviral therapy (cART) is critical during pregnancy in order to improve clinical follow-up, monitor viral load, and patient adherence to treatment. A modified simple and fast ultra-high performance liquid chromatography coupled with tandem mass spectrometry and electrospray ionization (UPLC-ESI-MS/MS) method was developed and validated according to national and international guidelines for the simultaneous determination of lamivudine (LMV), zidovudine (ZDV), lopinavir (LPV), and ritonavir (RTV) concentrations in 100-μL plasma sample of Human Immunodeficiency Virus (HIV)-positive pregnant women. Protein precipitation using 0.1% formic acid in cold acetonitrile was used for sample preparation. The chromatographic separation was achieved with a run-time of 3.0 minutes and 3-μL injection on an ethylene bridged hybrid C18 column (2.1 μm × 50 mm, 1.7 μm), under gradient conditions using acetonitrile and formic acid (0.1%). The chromatographic method was used to analyze 10 plasma samples from 8 HIV pregnant women as a clinical patient routinely follow-up by applying TDM criteria. The protonated precursor/product ion transitions for LMV (230.18/112.08), ZDV (268.22/127.10), LPV (629.55/447.35), and RTV (721.50/296.20) were recorded in multiple-reaction-monitoring (MRM) mode. The calibration curve was linear in the range of 50–3,000, 75–4,500, 250–15,000, and 25–1,500-ng/mL for LMV, ZDV, LPV, and RTV, respectively. The range of accuracy was 97.2% to 100.1% and precision 3.4% to 12.7%. The method showed specificity and matrix effect values of < 15%. Minimum absolute recovery percentages (%CV) were 90.5 (5.4), 90.8 (5.0), 95.4 (3.5), and 93.7 (6.9), for LMV, ZDV, LPV, and RTV, respectively. Drug concentrations in patient samples had high inter-individual variability with %CV of 91.98%, 77.54%, 53.80%, and 92.16% for ZDV, LMV, LPV, and RTV, respectively. Two of the 8 patients showed no adherence due to the absence of Protease Inhibitors (PIs) levels in plasma. This technique demonstrated to be effective in therapeutic drug monitoring and is intended to be used in population pharmacokinetics specifically for HIV-positive pregnant women.
Exercise adherence in breast cancer patients

Abstract To describe social support, self-efficacy, and exercise adherence and to measure the correlations among these factors in postoperative breast cancer patients in Southwest China. Social support, self-efficacy, and exercise adherence are interacting factors that contribute to physical and mental health and quality of life. Little is known about the status of these factors in Southwest China, and little research has explored the relationships among them. Using a stratified sampling method, we selected patients who underwent modified radical mastectomy in 20 secondary and tertiary comprehensive hospitals in Southwest China. A descriptive cross-sectional study was conducted. Questionnaires were given to 632 breast cancer patients who met the inclusion and exclusion criteria (from August 2018 to February 2019). The questionnaire included the following 4 sections: general information, perceived social support scale, strategies used by people to promote health, and postoperative functional exercise adherence scale. Structural equation modeling was used to evaluate the hypothesized relationships among social support, self-efficacy, and exercise adherence. The level of social support of postoperative patients with breast cancer in Southwest China was high (63.43 ± 9.25); however, levels of self-efficacy (95.00 ± 18.81) and exercise adherence (49.07 ± 10.57) were moderate. Higher social support correlated with higher exercise adherence (r = 0.526, P < .01). Higher self-efficacy was also correlated with higher exercise adherence (r = 0.427, P < .01). In-home support, out-of-home support, and self-efficacy had direct positive effects on exercise adherence (β = 0.37, P < .01; β = 0.23, P < .01; and β = 0.32, P < .01, respectively); in-home support indirectly affected exercise adherence through self-efficacy (β = 0.58, P < .01). Social support and self-efficacy correlated highly with exercise adherence. It is recommended that attention be paid to the development of self-efficacy and social support during postoperative rehabilitation to improve the exercise adherence of postoperative breast cancer patients.
Increased circulating levels of angiotensin-(1–7) in severely ill COVID-19 patients

The monocarboxypeptidase angiotensin-converting enzyme 2 (ACE2) is a major player in the the renin–angiotensin system (RAS) as it converts the decapeptide angiotensin (Ang) I to Ang-(1–9) and Ang II to Ang-(1–7) (figure 1a) [1]. ACE2 is also a target for the new human coronavirus SARS-CoV-2, which is responsible for the dramatic ongoing COVID-19 pandemic [2]. It has been suggested that following SARS-CoV-2/ACE2 internalisation, Ang II level increases [3] in parallel to a decrease of Ang-(1–7) level [4]. These changes would be expected both at tissue and circulatory levels. Considering that Ang-(1–7) has many beneficial effects, including anti-inflammatory, antithrombogenic and antifibrotic activities [1], it has been hypothesised that Ang-(1–7) administration would improve the clinical outcome of COVID-19 patients. Aiming to test this hypothesis, a phase I/II clinical trial (www.clinicaltrials.gov identifier NCT04633772) has been initiated with a planned phase III clinical trial (NCT04332666). This letter reports an unexpected increase of the ACE2 product angiotensin-(1–7) and a parallel decrease of its substrate angiotensin II, suggesting a dysregulation of the renin–angiotensin system towards angiotensin-(1–7) formation in #COVID19 patients https://bit.ly/3xFXuTU
Risk factors for SARS-CoV-2 infection among farmworkers in Monterey County, California

Importance: Essential workers in agriculture and food production have been severely affected by the ongoing COVID-19 pandemic. Objective: To identify risk factors associated with SARS-CoV-2 shedding and antibody response in farmworkers in California. Design: This cross-sectional study collected survey data and determined current SARS-CoV-2 shedding and seropositivity among 1,107 farmworkers in California's Salinas Valley from 16 July to 30 November 2020. Setting: Farmworkers receiving transcription-mediated amplification (TMA) tests for SARS-CoV-2 infection at federally qualified community clinics and community sites were invited to participate in our study. Participants: Individuals were eligible if they were not pregnant, were 18 years old or older, had conducted farm work since the pandemic started, and were proficient in English or Spanish. Exposures: Sociodemographic, household, community, and workplace characteristics. Main Outcome(s) and Measure(s): Current (as indicated by TMA positivity) and historical (as indicated by IgG seropositivity) SARS-CoV-2 infection. Results: Most farmworkers enrolled in the study were born in Mexico, had primary school or lower levels of educational attainment, and were overweight or obese. Current SARS-CoV-2 shedding was associated in multivariable analyses with attained only primary or lower educational levels (RR=1.32; 95% CI: 0.99-1.76), speaking an indigenous language at home (RR=1.30; 0.97-1.73), working in the fields (RR=1.60; 1.03-2.50), and exposure to known or suspected COVID-19 case at home (RR=2.98; 2.06-4.32) or in the workplace (RR=1.59; 1.18-2.14). Antibody detection was associated with residential exposures including living in crowded housing (RR=1.23; 0.98-1.53), with children (RR=1.40; 1.1-1.76) or unrelated roommates (RR=1.40; 1.19-1.64), and with a known or suspected COVID-19 case (RR=1.59; 1.13-2.24). Those who were obese (RR=1.65; 1.01-2.70) or diabetic (RR=1.31; 0.98-1.75) were also more likely to be seropositive. Farmworkers who lived in rural areas other than Greenfield (RR=0.58; 0.47-0.71), worked indoors (RR=0.68; 0.61-0.77), or whose employer provided them with information on how to protect themselves at work (RR=0.59; 0.40-0.86) had lower risk of prior infection.
Elasticity and Orientational Order in Some Cyanobiphenyls: Part IV. Reanalysis of the Data

Abstract We present revised absolute values of the elastic constants and order parameters of several cyanobiphenyls. The calculations make use of our earlier measurements of Freedericksz threshold fields and refractive indices, and corrected values of normalizing constants, particularly in respect of the anisotropy of magnetic susceptibility. The new values agree well with some recent measurements.
A meta-analysis of randomized controlled trial

Background: Local infiltration analgesia (LIA) has become popular in postoperative pain relief after total hip arthroplasty (THA) or total knee arthroplasty (TKA). The aim of this meta-analysis was to compare the efficacy and safety of LIA with intrathecal morphine and epidural analgesia after THA and TKA. Methods:A systematic article search was performed from PubMed, Embase, and Web of Science databases, up to February 21, 2019. The main outcomes included visual analog scale for assessment of pain, morphine equivalent consumption, length of hospital stay, and adverse events. The data were calculated using weight mean difference (WMD) or risk ratio (RR) with 95% confidence intervals (95% CIs). Results: Eleven studies with a total of 707 patients met the inclusion criteria and were included in this meta-analysis. LIA provided better pain control than other 2 techniques at 24-hour (WMD=10.61, 95%CI: 3.36–17.87; P= .004), 48-hour (WMD=16.0, 95%CI: 8.87–23.13; P< .001), and 72-hour (WMD=11.31, 95% CI: 3.78–18.83; P< .001). Moreover, LIA had similar morphine consumption and duration of hospital stay with intrathecal morphine and epidural analgesia. There was significantly lower incidence of adverse events with LIA than with the other 2 techniques. Conclusion: LIA provided better postoperative pain control and less adverse events than intrathecal morphine and epidural analgesia after THA and TKA. Abbreviations: LIA= Local infiltration analgesia, RCTs= randomized controlled trials, RR= risk ratio, THA= total hip arthroplasty, TKA = total knee arthroplasty, VAS = visual analog scale, WMD = weight mean difference.
THROMBOMODULINE IN CORRELATION WITH SYSTEMIC INFLAMMATION AND ATHEROSCELEROSIS IN CHRONIC RENAL DISEASE PATIENTS

Background: Chronic kidney disease (CKD) is a global health burden with high economic costs and an independent risk factor for cardiovascular disease in healthy systems (CVD). Nevertheless, in the development of atherosclerosis, chronic inflammation and endothelial dysfunction are critical events; both are present in CKD and HD patients. Thrombomodulin (TM) is a transmembrane glycoprotein originally located on the vascular endothelium that is expressed on the cell surface. In natural human anticoagulation systems, TM on vascular endothelial cells is a significant molecule. In atherosclerosis, TM has specific impacts on cell proliferation, adhesion and inflammation, all of which are essential measures. Aims: The aim of the present study is to detect the relationship between thrombomodulin and atherosclerosis in chronic kidney disease patients. Materials and Methods Thrombomodulin (TM) was assessed in blood specimens of 38 patients with CKD (19 patients with CKD who did not begin HD (Group 2) and 19 patients with CKD who were on regular HD for more than 6 months (Group 1) and compared to 19 control subjects (Group 3) (Control Group). Results: The mean value of Thrombomodulin (TM) in the control group (430.2±102), the mean value in the CKD predialysis group (521.1±198) and The mean value in the CKD on HD group (729.4±513),thus The mean values Thrombomodulin (TM cells in CKD on HD group was significantly higher than that of the control group (P=0.00), and The mean value of Thrombomodulin (TM) was higher in the CKD group for HD than in the CKD group for predialysis, and there was a substantial difference among the CKD group for predialysis and the CKD group for HD (P=0.00), but there was no substantial difference among the CKD group for predialysis and the control group (p=0.4). There is a high significant direct correlation between Thrombomodulin (TM) and CIM in the studied groups r=(0.618)and p(<0.01). Conclusions: In CKD patients, not only is Thrombomodulin (TM) strongly extended, but this expansion is correlated with preclinical atherosclerosis. In the CKD (predialysis and regular HD) groups, there was an independent association between thrombomodulin (TM, age, hsCRP) and IMT.
Functional Disability on Instrumental/Activities of Daily Livings Among Rural Older People in Nepal:

Background: Functional disability among older people is a growing concern for research for the quality of life of older people these days. The purpose of this paper is to present the situation of functional disability among Nepali elderly living in a rural area. Methods: This is a cross-sectional study from a rural area of Nepal. The total sample size for this study was 150 older persons 65 years and older. Functional disability on older people was assessed using internationally widely used instruments Activities of Daily Livings (ADLs) and Instrumental Activities of Daily Livings (IADLs). Results: Mean age of the older persons was 78.46 (±7.78) years. This study found a functional limitation on at least one ADL and IADL was 30% and 52%, respectively. Among the six items of ADLs highest problem was in incontinence (24%), followed by bathing (16%), use of toilet (14%), transfer within the home (10%), dressing and undressing (10%), and feeding (8%). Among IADLs highest dependency was in taking medicine (46%) followed by traveling (44%), shopping (40%), housekeeping (38%), and food preparation (34%). Conclusion: This study shows the functional limitations of Nepalese older persons living in the countryside are very high. ADLs and IADLs difficulties often correspond to the exact need for help, supervision, and hands-on care of an older person. The government should focus on some intervention programs for the wellbeing of older adults.
Department of Otolaryngology Institute of Audioneurotechnology Hannover Medical School Center for Systems Neuroscience University of Veterinary Medicine Hannover

Title: Functional Enhancement of Auditory Activation through Multi-Site Stimulation across the Isofrequency Dimension of the Inferior Colliculus Author: Behrouz Salamat Auditory midbrain implant (AMI) targets the inferior colliculus (IC) in patients with no implantable cochlea such as the patients with neurofibromatosis type 2 (NF2). The present study investigated a new version of the AMI which enables 3-dimensional (3D) stimulation across the IC. Using cats as an animal model, 3 human AMIs were implanted side by side in the IC. The inferior colliculus central nucleus (ICC) was electrically stimulated with different stimulation levels and the evoked local field potentials (LFP) were recorded from the primary auditory cortex (A1). The objectives of the current study were to determine the basic response properties based on the LFP to this stimulation (threshold, latency, dynamic range (DR)) and to compare this to the previous studies. Further, we wanted to investigate whether the IC stimulation provokes different cortical responses by varying the recording site. The present study demonstrates that the human AMI electrodes can selectively activate different neuronal populations in the ICs of the cat. Furthermore, the study indicates that the stimulation results in activation of partially overlapping neuronal populations, leading to responses at both ON-BF and OFF-BF recording positions in the cortex. In total, these data demonstrate some stimulation site specificity, but also a large overlap of the excitation pattern induced by midbrain stimulation.
THE ADDITION OF CITRIC AND LACTIC ACIDS AND THEIR MIXTURE TO THE PRODUCTIVE PERFORMANCE AND EGGS QUALITATIVE TRAITS OF THE LAYING HENS

This experiment is conducted for the period from 2-1-2016 to 26-2-2016 in the field of poultry at the Department of Animal Wealth/ college of Agriculture/ University of Diyala. The experiment is designed using 120 egg laying brown lohmann hens, aged 37 weeks, distributed over four different treatments, with 3 replicates per treatment, each contains ten hens. The treatments are distributed in the following way: 1. Controlled treatment with no addition; 2. Adding 4.0% lactic acid; 3. Adding 4.0% citric acid; 4. Adding 8.0 % of the mixture of both lactic and citric acids. The findings show a significant primacy (p> 0.01) and (p >0.05) of the treatments with the addition of the organic acids (citric and lactic) and their mixture on the cumulative eggs production based on the (hen day production) H.D. %, as well as eggs mass and feed conversion coefficient compared with the controlled treatment. Furthermore, the findings show no differences in the average of eggs weight among the treatments with the organic acids compared with the controlled treatment.
Hydrothermal Synthesis, Crystal Structure, and Magnetic Properties of Cs[(V2O3)(HPO4)2(H2O)], a Mixed-Valence Vanadium (IV, V) Hydrogen Phosphate with a One-Dimensional (-VIV-O-VV-O-) Chain of Corner-Sharing VO6 Octahedra

Abstract The hydrothermal reaction of Cs4V2O7, V, H3PO4, H2O, and Bu4NBr in the molar ratio 4.5:1:41:3150:1 at 200°C for 48 hr yielded the red-brown cesium vanadium phosphate Cs[(V2O3) (HPO4)2(H2O)], a mixed-valence V(IV, V) species. The structure contains corner-sharing vanadium octahedra and phosphorus tetrahedra with unusual 1-D (-VIV-O-VV-O-)∞ chains formed from VO6 octahedra sharing opposite corners. These chains are connected through tridentate bridging (HPO4)2- units to produce a three-dimensional network. The Cs+ cations occupy large channels formed from six vanadium octahedra and six phosphorus tetrahedra. At room temperature the material is paramagnetic with one unpaired spin per (-VIV-O-VV-O-) unit while complicated antiferromagnetic ordering is observed below ca. 6 K. Crystal data: monoclinic, P 21/n with a = 7.22(1), b = 18.56(1), c = 8.195(6) A, β = 114.01(6)°, Z = 4, dcalc = 3.233 g cm-3; structure solution and refinement based on 1088 reflections converged at R = 0.028.