Miracle-dz/UniFAR-FTUs huggingface dataset:
Pretreatment Epstein-Barr Virus DNA Load and Cumulative Cisplatin Dose Intensity Affect Long-Term Outcome of Nasopharyngeal Carcinoma Treated with Concurrent Chemotherapy: Experience of an Institute in an Endemic Area

Background: We retrospectively compared the long-term efficacy of concurrent chemoradiotherapy (CCRT) regimens (docetaxel vs. cisplatin), total dose intensity of cisplatin (> 200 vs. ≤ 200 mg/m2) and pretreatment plasma levels of Epstein-Barr virus (EBV) DNA for nasopharyngeal carcinoma (NPC), and investigated the prognostic factors. Methods: We enrolled 214 patients diagnosed with NPC and treated with CCRT. 41 patients received weekly docetaxel and 173 weekly cisplatin. 62 received cumulative cisplatin of ≤ 200 mg/m2 and 111, > 200 mg/m2. Pretreatment levels of EBV DNA were available for 155 patients. Results: Patients receiving concurrent weekly docetaxel and cisplatin had similar 5-year rates for overall survival (OS) (p = 0.306), progression-free survival (PFS) (p = 0.133), distant failure-free survival (DFS) (p = 0.110), and locoregional failure-free survival (LFS) (p = 0.452). Cumulative cisplatin of > 200 mg/m2 improved the 5-year rates of PFS (p = 0.018) and DFS (p = 0.042) significantly in comparison with cumulative cisplatin of ≤ 200 mg/m2. EBV DNA levels of ≥ 1,500 copies/ml was closely associated with poor DFS (p = 0.011), PFS (p = 0.006), and OS (p = 0.004). Conclusions: Weekly cisplatin was well tolerated in CCRT, during which cumulative cisplatin of > 200 mg/m2 improved PFS and DFS. The long-term efficacy of concurrent docetaxel was similar to that of concurrent cisplatin. The EBV DNA level was the most significant prognostic factor.
PAPER Small on the left, large on the right: numbers orient visual attention onto space in preverbal infants

Numbers are represented as ordered magnitudes along a spatially oriented number line. While culture and formal education modulate the direction of this number – space mapping, it is a matter of debate whether its emergence is entirely driven by cultural experience. By registering 8 – 9-month-old infants ’ eye movements, this study shows that numerical cues are critical in orienting infants ’ visual attention towards a peripheral region of space that is congruent with the number ’ s relative position on a left-to-right oriented representational continuum. This finding provides the first direct evidence that, in humans, the association between numbers and oriented spatial codes occurs before the acquisition of symbols or exposure to formal education, suggesting that the number line is not merely a product of human invention.
An Examination of the Role of Social Influence and Organizational Hierarchy on Knowledge Management System Usage

Recent work on the social nature of relocating knowledge identifies knowledge management and its facets as a complex process, going well beyond the simple transfer of bundles of knowledge. This increase in the number of knowledge transfer studies has also led to new insights regarding knowledge management systems (KMSs). Still, we know little about the role of social influence in stimulating individuals to share through KMSs. Thus, we propose a framework for examining the role of social influence at different levels of the organizational hierarchy and its effects on KMS usage. Specifically, the research model examines the moderating effect of the hierarchical level of an employee on the relationship between prior KMS use by employees at various hierarchical levels and current KMS use. We define a set of propositions based on social influence theory to further our understanding of how organizations can facilitate knowledge sharing within their boundaries.
Assessing the Accuracy of Plagiarism Detection Systems

Plagiarism in academic writing is known to be an issue of concern for educators, administrators, and students alike. Using self-reporting studies and plagiarism detection software, previous research has established that plagiarism in university-level academic writing is relatively common amongst the work of L1 and particularly L2 writers and that paraphrasing and the various definitions of what constitutes plagiarism are notable challenges. However, previous research has been limited in the plagiarism detection systems used to evaluate student writing and has shed little light on their accuracy. This study seeks to contribute to scholarship on plagiarism by both measuring potential plagiarism in the writing of students at a university in Japan and assessing the accuracy of two plagiarism detection systems, Google Classroom and Grammarly. It was found that student writing was slightly less likely to feature content which may be deemed plagiarized, and the total amount of such content as a percentage of the total was notably low. The accuracy of the two systems differed greatly, with the Google Classroom version being more reliable in terms of generating fewer false positives and having more potential to be used as a self-editing or learning tool for students.
MOOD STATE AND RISK TOLERANCE IN ORGANIZATIONAL DECISIONS

Objective of the study: This study aims to identify the relationship between an individual's mood and risk tolerance in organizational decisions. Methodology/approach: It is an applied, quantitative, descriptive and survey research. For data collection, a questionnaire was applied to a sample of 90 academics from higher education courses in the area of management at a Higher Education Institution in the State of Santa Catarina. Data were categorized and analyzed quantitatively using descriptive statistics, correlation analysis and logistic regression analysis. Originality/relevance: Researches relate positive mood and increased risk-taking, however, the results are fragmented and inconclusive as to the influence of negative mood on the tendency to take risks. Thus, this research focuses attention on the asymmetry of influence of both positive and negative mood on risk preferences. Main results: We found that in decisions involving gains, respondents have less tolerance than when they involve losses. Although mood is not related to risk tolerance, when analyzed separately, a relationship was found between the dimensions of mood and the individuals' risk tolerance. Theoretical/methodological contributions: This research adds to the literature, by exploring decision-making and the behavioral line simultaneously, as well as contributing to represent a more comprehensive description regarding the decision process regarding the Prospect Theory, by demonstrating which dimensions of mood have an influence on the risk tolerance of respondents. Social/management contributions: The study contributes to the improvement of decision-making processes in the context of aspects related to risk tolerance. The practical implications refer to the construction of a decision-making process designed in a more assertive way and in line with the losses and gains arising from the inherent risk of this decision-making process.
The Effect of Plyometric Warm-Ups Applied in Different Sets Using Resistance Bands on Jump Performance

The aim of this study is to investigate the effect of vertical jumping performed in different sets using resistance bands with vertimax device on jump performance as a PAP warm-up stimulus. Fifteen athletes (age: 20.00±2.33; height: 175.07±7.23; weight: 68.71±14.36) from short and middle distances of athletics who have been doing exercise regularly at least 5 days a week for a minimum of 5 years were participated in this study. The athletes participating in this study were firstly warmed up on a treadmill at a speed of 8 km/h for 5 minutes and then 5 minutes of passive rest was applied. After the passive rest period, the athletes were randomly sampled and one of the PAP warm-up protocols consisting of 1, 2 and 3 sets of 10 repetitions with 80 lb resistance on the Vertimax device or without any resistance was applied. The athletes who performed any warm-up protocol were applied. The warm-up protocols that the athletes did not perform were randomly applied in at least 48 hours breaks. Repeated measures of ANOVA test were used to analyze the results of the variables of the athletes participating in the study. The results of the analysis showed that there are significant differences in squat and multi-jump values after warm-up protocols without applying any resistance and 1, 2 and 3 sets of PAP warm-up applications that consisting of 10 repetitions on the Vertimax device (p<0.05). The squat jump height values were found to be significantly higher in 1, 2 and 3 sets of PAP warm-up applications with resistance bands than warm-up protocols without applying any resistance (p<0.05). On the other hand, squat jump height values after 2 and 3 sets of PAP warm-up applications with resistance bands were found to be significantly higher than 1 set of PAP warm-up applications with resistance bands (p<0.05). The multiple jump height values were found to be significantly higher in 2 and 3 sets of PAP warm-up applications with resistance bands than warm-up protocols without applying any resistance (p<0.05). In conclusion, we can say that the vertical jump warm-up applications with resistance bands that includes different sets on the vertimax device as PAP stimulus have a significant effect on jump performance depending on the number of sets.
E ﬀ ect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

: (1) Background: Breast milk is the only source of nutrition for breastfed infants, but few studies have examined the relationship between breast milk micronutrients and infant neurodevel-opmental outcome in exclusively breastfed infants. The aim of this study was to characterize the association between nicotinamide adenine dinucleotide (NAD)-related compounds in the breast milk of Japanese subjects and infant neurodevelopmental outcome. (2) Methods: A total of 150 mother–child pairs were randomly selected from the three-generation cohort of the Tohoku Medical Megabank in Japan. Infants were exclusively breastfed for up to 6 months. Breast milk was collected at 1 month postpartum, and the quantity of NAD-related substances in the breast milk was quanti-ﬁ ed. The mothers also completed developmental questionnaires at 6, 12, and 24 months. The relationship between the concentration of NAD-related substances in breast milk and developmental indicators was evaluated via ordinal logistic regression analysis. (3) Results: Nicotinamide mono-nucleotide (NMN) was quanti ﬁ ed as the major NAD precursor in breast milk. The median amount of NMN in the breast milk was 9.2 µM. The NMN concentration in breast milk was the only NAD-related substance in breast milk that showed a signi ﬁ cant positive correlation with neurodevelopmental outcome in infants at 24 months. (4) Conclusions: The results suggest that NMN in human milk may be an important nutrient for early childhood development.
NetShuffle: Circumventing Censorship with Shuffle Proxies at the Edge

—NetShuffle is a censorship resistance system that offers “shuffle proxies,” where regular proxy services (e.g., HTTPS proxies, Tor bridges) are decoupled from their addresses via continuous in-network change. This makes shuffle proxies significantly more difficult to block compared to their traditional counterparts, because the network locations are now in constant flux. NetShuffle is also designed to engage a new class of support base—edge networks—which have received scant attention from existing work. NetShuffle uses emerging programmable switches to provide the shuffle, while staying otherwise transparent to services and clients, enabling it to be applied as a drop-in network appliance to help promote Internet freedom. We have prototyped NetShuffle in testbed environments and operated it seamlessly on a slice of a live campus network for more than a month, showing that it provides network shuffles in a way that is transparent and incurs negligible overheads.
Diﬀ erent Forms of Huntingtin in the Most Aﬀ ected Organs; Brain and Testes of Transgenic Minipigs Různé formy huntingtinu v nejvíce postižených orgánech; mozku a varlatech transgen ních miniprasat

Huntington’s disease (HD) is a neurodegenerative disorder caused by the the elongation of CAG triplet repeat in the gene encod ing the huntingtin protein (Htt). In patients, in addition to the monomeric form of huntingtin, N-terminal fragments, oligomers, and polymers are present mostly in the aﬀ ected tis sues, even though the mutated huntingtin (mtHtt) is expres sed basical ly in al l cel ls. The most aﬀ ected tis sues are basal ganglia and cerebral cortex. In this study we analyzed the presence of N-terminal fragments and oligomers of Htt in diﬀ erent tis sues of 24 and 36 months old experimental animals. This was done in our large animal model of HD, which uses transgenic (TgHD) minipigs expres s ing N-terminal part of human mtHtt. Among al l the tis sues tested, we found cortex and testes to contain N-terminal fragments as wel l as oligomeric smears in TgHD minipigs compared to wild type siblings. On the other hand, we did not detect any fragments or oligomers in muscle and heart of TgHD minipigs, only start ing fragmentation in muscles of 36 months old animals. These ﬁ ndings mimic the early progres sion of the disease in humans, hence presents minipig as a promis ing model for therapeutic test ing of HD.
Oscillator without a combinatorial loop and its threat to FPGA in data centre

Virtual field-programmable gate array (FPGA) is an emerging technology to put multiple users in the same FPGA fabric with logical isolation. Security researchers have studied new threats in virtual FPGA and proposed attacks on the logical isolation by exploiting analogue natures of FPGA. These attacks use an oscillator comprising a combinatorial loop to have access to the analogue domain using digital components only. Interestingly, the system in the field prohibits a combinatorial loop by a design rule check. In this Letter, the authors study if prohibiting a combinatorial loop is sufficient to thwart the conventional attacks. They negatively answer the question by showing oscillators without a combinatorial loop. They also show how to detect and reject the proposed oscillators by a design rule check.
On the properties of ensemble forecast sensitivity to observations

Evaluating impacts of observations on the skill of numerical weather prediction (NWP) is important. The Ensemble Forecast Sensitivity to Observation (EFSO) provides an efficient approach to diagnosing observation impacts, quantifying how much each observation improves or degrades a subsequent forecast with a given verification reference. This study investigates the sensitivity of EFSO impact estimates to the choice of the verification reference, using a global NWP system consisting of the Non‐hydrostatic Icosahedral Atmospheric Model (NICAM) and the Local Ensemble Transform Kalman Filter (LETKF). The EFSO evaluates observation impacts with the moist total energy norm and with recently proposed observation‐based verification metrics. The results show that each type of observation mainly contributes to the improvement of forecast departures of the observed variable maybe due to the limitation of localization in the EFSO. The EFSO overestimates the fraction of beneficial observations when verified with subsequent analyses, especially for shorter lead times such as 6 h. We may avoid this overestimation to some extent by verifying with observations, analyses from other data assimilation (DA) systems, or analyses of an independent run with the same DA system. In addition, this study demonstrates two important issues possibly leading to overestimating observation impacts. First, observation impacts would be overestimated if we apply relaxation‐to‐prior methods to the initial conditions of the ensemble forecasts in the EFSO; therefore, the ensemble forecasts in the EFSO should be independent of the ensemble forecasts in the DA cycle. Second, deterministic baseline forecasts of the EFSO, which represent the forecast without DA, should be initialized by the ensemble mean of the first guess at the analysis time, not by the previous analysis.
Therapeutic Management of Children with Vesicoureteral Reflux

Contrasting data refer to therapies for vesicoureteral reflux (VUR), such as surgical treatments and continuous antibiotic prophylaxis (CAP). This study evaluated the effectiveness of these approaches in children with VUR, analyzing the recurrence of febrile urinary tract infections (UTIs) and the resolution of VUR after the treatment. A total of 350 pediatric patients underwent contrast-enhanced voiding urosonography (ceVUS) to diagnose a VUR, whereas renal scintigraphy evaluated potential scars. After 12 months from the treatment, the VUR, the relapse of febrile UTIs, and reflux-related nephropathy were analyzed. Twenty-seven children had recurrent febrile UTIs after surgical therapy, with a greater rate of relapses observed in III and V VUR grades. Thirteen patients who underwent surgery had scars, independently of VUR grades and gender, with evidence of chronic renal failure at the end of the follow-up period. A total of 140 subjects were treated with CAP, and 30% of them continued to suffer from febrile UTIs. Ninety-five patients with VUR underwent ceVUS after 12 months, with persistent reflux in fifty-two patients. All of them had severe VUR, correlating with the age at diagnosis and gender. CAP therapy prevented scarring better than surgery, especially in children with III and V grades of VUR. A late onset of VUR or VUR involving neonatal patients is rarely a reversible process. This study identified predictors of success or failure of surgical or CAP therapies, evaluating the relapse of UTIs or persistent reflux after the treatment and giving prognostic information in children with VUR.
Effect of diluters on frozen semen production of Black Bengal Goat

The present study was undertaken to investigate the efficacy of three diluters (Triladyl, Andromed and Tris) for the production of frozen semen in Black Bengal goat and their effect on conception rate. Over the course of 6 months, data from six bucks were collected. Each collected sample was diluted with Triladyl, Andromed and Tris diluter, filled into 0.50 ml straws, sealed and equilibrated at 5℃ for freezing. The motility, viability and morphology were evaluated after dilution and in every step of cryopreservation (after equilibration, after freezing and after thawing). It became clear that motility and sperm viability of the frozen thawed semen differed significantly (p<0.05) but differed insignificantly (p>0.05) immediate after dilution among the diluters. The motility of frozen thawed semen was 42.50%±1.71, 34.67%±1.67 and 28.71%±1.55 in Triladyl, Andromed and Tris diluter, respectively. The viability of frozen thawed semen was 40.51%±1.78, 32.24%±1.52 and 26.84%±1.56 in Triladyl, Andromed and Tris diluter, respectively. In case of morphology, it differed insignificantly (p>0.05) among the diluters in every step of cryopreservation. Higher percentage of normal spermatozoa was found in Triladyl based diluter (87.11%) in frozen thawed semen. After 15 days of sample preparation, the motility of prepared sample was again checked to ensure the quality of frozen semen in liquid nitrogen (LN). It differed insignificantly (p>0.05) with frozen thawed semen after 24 hours of production. The obtained conception rate was 38% for Triladyl, 35% for Andromed and 27% for Tris diluter. The results of the study revealed that cryopreservation of buck semen revealed good results with Triladyl diluter followed by Andromed and Tris diluter. Bangladesh Journal of Animal Science 52 (4): 105-113
Health Consequences Among COVID-19 Convalescent Patients 30 Months Post-Infection in China

The health consequences among COVID-19 convalescent patients 30 months post-infection were described and the potential risk factors were determined. In August 2022 we recruited 217 COVID-19 convalescent patients who had been diagnosed with COVID-19 in February 2020. These convalescent patients were residents of multiple districts in Wuhan, China. All convalescent patients completed a detailed questionnaire, laboratory testing, a 6-min walk test, a Borg dyspnea scale assessment, lung function testing, and had a chest CT. The potential risk factors for health consequences among COVID-19 convalescent patients 30 months post-infection were identified using a multivariate logistic regression model. The majority of convalescent patients were in good overall health and returned to work 30 months post-infection; however, 62.2% of the convalescent patients had long COVID symptoms. The most common symptoms were chest pain, fatigue, and dizziness or headaches. The convalescent patients with severe symptoms had a significantly higher proportion of depression disorder (P = 0.044) and lower health-related quality of life (P = 0.034) compared to the convalescent patients with mild symptoms. Compared to convalescent patients who were not vaccinated, convalescent patients who received three vaccines had significantly less fatigue, lower anxiety and depression scores, and had a better health-related quality of life (all P < 0.05). Older age was associated with a higher risk of long COVID (OR = 1.52, 95% CI = 1.16–2.02) and chest CT abnormalities (OR = 1.75, 95% CI = 1.33–2.36). Female gender was associated with a higher risk of anxiety (OR = 3.20, 95% CI = 1.24–9.16) and depression disorders (OR = 2.49, 95% CI = 1.11–5.92). Exercise was associated with a lower risk of anxiety (OR = 0.41, 95% CI = 0.18–0.93). Notably, vaccination protected convalescent patients from developing long COVID symptoms (OR = 0.18, 95% CI = 0.06–0.50), anxiety disorders (OR = 0.22, 95% CI = 0.07–0.71), and depression disorders (OR = 0.33, 95% CI = 0.12–0.92). The majority of COVID-19 convalescent patients were in good overall health 30 months post-infection and returned to work. More attention should be paid to convalescent patients who are older, female, physically inactive, and not vaccinated.
Navigating containment challenges: A quantitative study of Ghanaian SME performance during the COVID-19 pandemic

This study aims to provide valuable insights into the containment challenges faced by Ghanaian SMEs during the COVID-19 pandemic and how these challenges impacted key performance indicators (KPIs). Utilizing the partial least square approach of structural equation modelling (PLS-SEM), data collected from a sample of 152 Ghanaian SMEs are examined. The findings underscore the adverse influence of pandemic-related containment measures on financial performance, sales performance, employee satisfaction, and customer satisfaction, while revealing an increase in online engagement as SMEs adapted their business models. Thus, this study highlights the significance of bolstering dynamic capabilities, with a particular focus on digital transformation and leveraging online platforms, as a means to enhance resilience and adaptability for SMEs amidst challenging containment conditions. Theoretical implications emphasize the crucial role of dynamic capabilities in navigating uncertainty and volatility during crises, while the practical implications offer valuable guidance for small business owners in developing economies as they strive to mitigate the impacts of containment measures during public health emergencies on their businesses