Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Chronic Kidney Disease on In-Hospital Outcomes of Hospitalizations With Acute Limb Ischemia Undergoing Endovascular Therapy.

PURPOSE Studies on outcomes related to endovascular treatment (EVT) in advanced stages of chronic kidney disease (CKD) and end-stage renal disease (ESRD) among hospitalizations with acute limb ischemia (ALI) are limited. METHODS The Nationwide Inpatient Sample was quarried from October 2015 to December 2017 to identify the hospitalizations with ALI and undergoing EVT. The study population was subdivided into 3 groups based on their CKD stages: group 1 (No CKD, stage I, stage II), group 2 (CKD stage III, stage IV), and group 3 (CKD stage V and ESRD). The primary outcome was all-cause in-hospital mortality. RESULTS A total of 51 995 hospitalizations with ALI undergoing EVT were identified. The in-hospital mortality was significantly higher in group 2 (OR = 1.17; 95% CI 1.04 - 1.32, p=0.009) and group 3 (OR = 3.18; 95% CI 2.74-3.69, p<0.0001) compared with group 1. Odds of minor amputation, vascular complication, atherectomy, and blood transfusion were higher among groups 2 and 3 compared with group 1. Group 2 had higher odds of access site hemorrhage compared with groups 1 and 3, whereas group 3 had higher odds of major amputation, postprocedural infection, and postoperative hemorrhage compared with groups 1 and 2. Besides, groups 2 and 3 had lower odds of discharge to home compared with group 1. Finally, the length of hospital stay and cost of care was significantly higher with the advancing CKD stages. CONCLUSION Advanced CKD stages and ESRD are associated with higher mortality, worse in-hospital outcomes and higher resource utilization among ALI hospitalizations undergoing EVT. CLINICAL IMPACT Current guidelines are not clear for the optimum first line treatment of acute limb ischemia, especially in patients with advanced kidney disease as compared to normal/mild kidney disease patients. We found that advanced kidney disease is a significant risk factor for worse in-hospital morbidity and mortality. Furthermore, patients with acute limb ischemia and advanced kidney disease is associated with significantly higher resource utilization as compared to patients with normal/mild kidney disease. This study suggests shared decision making between treating physician and patients when considering endovascular therapy for the treatment of acute limb ischemia in patients with advanced kidney disease.
Definitive local therapy for extracranial single-organ oligorecurrent non-small-cell lung cancer: A single institutional retrospective study

Oligometastatic non-small-cell lung cancer (NSCLC) is potentially curable. Oligo-recurrence occurs with oligometastatic disease characterized by well-controlled primary lesion. The purpose of the present study was to explore the value of definitive local therapy (DLT) for extracranial single-organ oligorecurrent NSCLC. A total of 81 patients with NSCLC who had extracranial single-organ oligorecurrence after receiving radical treatment at the Cancer Hospital of the University of Chinese Academy of Sciences from January 2010 to December 2017 were analyzed. The primary endpoint was progression-free survival (PFS), and the secondary endpoint was overall survival (OS). The median follow-up time of the 81 patients was 65.8 months. A total of 39 patients received DLT. A large proportion of patients who did not accept DLTs received specific tyrosine kinase inhibitors (TKIs). The results of multivariate analysis showed that DLT and specific TKI therapy were favorable prognostic factors significantly related to PFS. Further analysis showed that for patients without specific TKI therapy, DLT significantly improved PFS and the 5-year PFS rate. The 5-year OS rate also improved, but the improvement was not significant. For extracranial single-organ oligorecurrent NSCLC, PFS was significantly superior in patients receiving DLT. Among them, for the subgroup of patients who did not receive specific TKI therapy, DLT is expected to improve long-term prognostic outcomes.
Plasma proteins from several components of the immune system differentiate chronic widespread pain patients from healthy controls – an exploratory case-control study combining targeted and non-targeted protein identification

Chronic widespread pain (CWP), including fibromyalgia (FM), is characterized by generalized musculoskeletal pain and hyperalgesia. Plasma proteins from proteomics (non-targeted) and from targeted inflammatory panels (cytokines/chemokines) differentiate CWP/FM from controls. The importance of proteins obtained from these two sources, the protein-protein association network, and the biological processes involved were investigated. Plasma proteins from women with CWP (n = 15) and CON (n = 23) were analyzed using two-dimensional gel electrophoresis analysis and a multiplex proximity extension assay for analysis of cytokines/chemokines. Associations between the proteins and group were multivarietly analyzed. The protein-protein association network and the biological processes according to the Gene Ontology were investigated. Proteins from both sources were important for group differentiation; the majority from the two-dimensional gel electrophoresis analysis. 58 proteins significantly differentiated the two groups (R2 = 0.83). A significantly enriched network was found; biological processes were acute phase response, complement activation, and innate immune response. As with other studies, this study shows that plasma proteins can differentiate CWP from healthy subjects. Focusing on cytokines/chemokines is not sufficient to grasp the peripheral biological processes that maintain CWP/FM since our results show that other components of the immune and inflammation systems are also highly significant.
Exploring the relationship between novel Coronavirus pneumonia and Parkinson’s disease

The hypothesis is that there is 0a relationship between Parkinson’s disease and coronavirus disease 2019 (COVID-19). By summarizing the pathogenesis of Parkinson’s disease and COVID-19 and the impact of COVID-19 on the central nervous system, the relationship between Parkinson’s disease and COVID-19 was analyzed, including whether Parkinson’s disease is a predisposition factor for COVID-19 and whether COVID-19 causes the occurrence of Parkinson’s disease. Discuss the impact of COVID-19 on patients with Parkinson’s disease, including symptoms and life impact. To summarize the principles, goals and methods of home rehabilitation for Parkinson’s disease patients during COVID-19. Through the analysis of this paper, it is believed that COVID-19 may cause Parkinson’s disease. Parkinson’s disease has the condition of susceptibility to COVID-19, but this conclusion is still controversial.
Paraoxonase 1 and atrial fibrillation: Is there a relationship?

Atrial fibrillation (AF) is associated with oxidative stress and inflammation. Paraoxonase-1 (PON1), circulates in blood bound to high-density lipoproteins and reduces systemic oxidative stress. The aim of this study was to evaluate PON1 serum concentration and PON1 arylesterase activity (AREase) in patients with AF. We studied a group of 67 patients with symptomatic paroxysmal or persistent AF admitted for cardioversion and a control group of 59 patients without AF. Clinical parameters, lipid profile, PON1 concentration and AREase were evaluated. A significant difference in serum PON1 concentration and in AREase was found among the two groups. In a multivariate linear regression model, the presence of AF was associated with low PON1 concentration (P = .022). The body mass index was also independently associated with PON1 values (P < .001). Only the high-density lipoproteins-cholesterol level was independently associated with AREase (P = .002). PON1 serum concentrations and AREase were diminished in patients with AF, and the presence of AF was independently associated with low PON1 values.
Physical parameters of RR Lyrae stars in NGC 6171

We present an analysis of VI CCD time-series photometry of the globular cluster NGC 6171. The main goal is to determine individual physical parameters for single-mode RR Lyrae stars present in the field of view of our images, by means of light curve Fourier decomposition and well-established calibrations and zero-points. This leads to the estimation of the mean values of the metallicity and distance for the parental cluster. From the RRab stars we find [Fe/H]ZW = -1.33 +- 0.12 and a distance d = 5.3 +- 0.3 kpc and from the RRc stars we find [Fe/H]ZW = -1.02 +- 0.19 and a distance d = 5.3 +- 0.2 kpc. Independent methods, such as the P-L relations for RRab and SX Phe stars enable the estimation of a weighted average distance to the cluster of 5.4 +- 0.1 kpc. We confirm the amplitude modulations of the Blazhko type of five RRab and the non-membership of V21 to the cluster. The colour-magnitude diagram is consistent with an age of 11 Gyrs. The distribution of RRab and RRc stars seems well segregated around the first overtone red edge of the instability strip. This positions NGC 6171 among OoI type clusters where the pulsating modes are neatly separated in the HB. We report two new irregular variables of the Lb type.
Mitigation and adaptation emissions embedded in the broader climate transition

Significance Adapting to increasing climate risks while deploying renewables to stabilize the climate will require large amounts of energy and materials, which will initially cause emissions. We provide an estimate of the CO2 emissions embedded in this broader climate transition, which were previously poorly quantified. Fossil fuel energy use to deploy renewables contributes the vast majority of embedded emissions, with a much smaller contribution from adaptation. As a result, embedded emissions increase substantially for slower decarbonization pathways. However, when renewables are rapidly deployed, the ongoing transition can be powered by cleaner energy, minimizing embedded emissions. Our results demonstrate an underappreciated benefit of enhanced climate ambition and the importance of accounting for embedded transition emissions to achieve climate objectives.
Conditions for Steady Gravitational Radiation from Accreting Neutron Stars

The gravitational wave- and accretion-driven evolution of the angular velocity, core temperature, and (small) amplitude of an r-mode of neutron stars in low-mass X-ray binaries and similar systems is investigated. The conditions required for evolution to a stable equilibrium state (with gravitational wave flux proportional to average X-ray flux) are determined. In keeping with conclusions derived from observations of neutron star cooling, the core neutrons are taken to be normal while the core protons and hyperons and the crust neutrons are taken to be singlet superfluids. The dominant sources of damping are then hyperon bulk viscosity (if much of the core is at least 2-3 times nuclear density) and (e-e and n-n) shear (and possibly magnetic) viscosity within the core-crust boundary layer. It is found that a stable equilibrium state can be reached if the superfluid transition temperature of the hyperons is sufficiently small (≲2 × 109 K), allowing the gravitational radiation from Sco X-1 and several other neutron stars in low-mass X-ray binaries to be potentially detectable by the second-generation LIGO (and VIRGO) arrays.
The Long-term Secular Mass Accretion Rate of the Recurrent Nova T Pyxidis

We present Hubble Space Telescope ultraviolet spectroscopy of the recurrent nova T Pyxidis obtained more than five years after its 2011 outburst, indicating that the system might not have yet reached its deep quiescent state. The ultraviolet data exhibit a 20% decline in the continuum flux from the pre-outburst deep quiescence state to the post-outburst near quiescent state. We suggest that a decline across each recurring nova eruption might help explain the proposed 2 mag steady decline of the system since 1866. Using an improved version of our accretion disk model as well as International Ultraviolet Explorer ultraviolet and optical data, and the 4.8 kpc distance derived by Sokoloski et al. (and confirmed by De Gennaro Aquino et al.), we corroborate our previous findings that the quiescent mass accretion rate in T Pyx is of the order of 10−6 M⊙ yr−1. Such a large mass accretion rate would imply that the mass of the white dwarf is increasing with time. However, with the just-released Gaia DR 2 distance of ∼3.3 kpc (after submission of the first version of this manuscript), we find a mass accretion rate more in line with the estimate of Patterson et al., of the order of 10−7 M⊙ yr−1. Our results predict powerful soft X-ray or extreme ultraviolet emission from the hot inner region of the high accretion rate disk. Using constraining X-ray observations and assuming that the accretion disk does not depart too much from the standard model, we are left with two possible scenarios. The disk either emits mainly extreme ultraviolet radiation, which, at a distance of 4.8 kpc, is completely absorbed by the interstellar medium, or the hot inner disk, emitting soft X-rays, is masked by the bulging disk seen at a higher inclination.
A meta‐analysis examined the effect of stoma on surgical site wound infection in colorectal cancer

To assess the impact of a stoma on surgical site wound infection in colorectal cancer, we conducted a meta‐analysis. A thorough review of the literature up to September 2022 revealed that 3223 participants had colorectal cancer at the start of the investigations; 258 of them had a stoma, while 2965 did not have a stoma. Using dichotomous or contentious methods and a random or fixed‐effect model, odds ratios (OR) and mean difference (MD) with 95% confidence intervals (CIs) were estimated to evaluate the impact of a stoma on surgical site wound infection in colorectal cancer. The stoma present had significantly higher surgical site wound infections (OR, 4.37; 95% CI, 3.08–6.21; P < 0.001) with no heterogeneity (I2 = 12%) compared to stoma absent in colorectal cancer. The stoma present had significantly higher surgical site wound infections compared to the stoma absent in colorectal cancer. The low number of selected studies in the meta‐analysis calls for care when analysing the results.
Colliding Alfvénic wave packets in magnetohydrodynamics, Hall and kinetic simulations

The analysis of the Parker–Moffatt problem, recently revisited in Pezzi et al. (Astrophys. J., vol. 834, 2017, p. 166), is here extended by including Hall magnetohydrodynamics and two hybrid kinetic Vlasov–Maxwell numerical models. The presence of dispersive and kinetic features is studied in detail and a comparison between the two kinetic codes is also reported. Focus on the presence of non-Maxwellian signatures shows that – during the collision – regions characterized by strong temperature anisotropy are recovered and the proton distribution function displays a beam along the direction of the magnetic field, similar to some recent observations of the solar wind.
Understanding the Reactivity of Supported Late Transition Metals on a Bare Anatase (101) Surface: A Periodic Conceptual DFT Investigation.

The rapidly growing interest for new heterogeneous catalytic systems providing high atomic efficiency along with high stability and reactivity triggered an impressive progress in the field of single-atom catalysis. Nevertheless, unravelling the factors governing the interaction strength between the support and the adsorbed metal atoms remains a major challenge. Based on periodic Density Functional Theory (DFT) calculations, this paper provides insight into the adsorption of single late transition metals on a defect-free anatase surface. Depending on the considered transition metal, we could attribute the strength of this interaction with the support to: i) an electron transfer towards anatase (Ru, Rh, Ni), ii) s-d orbital hybridisation effects (Pt), or iii) a synergistic effect between both factors (Fe, Co, Os, Ir). The driving forces behind the adsorption were also found to be strongly related to Klechkowsky's rule for orbital filling. In contrast, the deviating behaviour of Pd is most likely associated with the lower dissociation enthalpy of the Pd-O bond. Additionally, the reactivity of these systems was evaluated using the Fermi weighted density of states approach. The resulting softness values can be clearly related to the electron configuration of the catalytic systems as well as with the net charge on the transition metal. Finally, these indices were used to construct a model that predicts the adsorption strength of CO on these anatase-supported d-metal atoms.
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics

Objective: The aim of our study was to describe the distinct features of inflammatory bowel disease (IBD) in juvenile idiopathic arthritis (JIA) patients and to identify risk factors for its development. Methods: Data from the German biologics in pediatric rheumatology registry (Biologika in der Kinderrheumatologie) collected between 2001 and 2021 were analyzed retrospectively. Results: In 5009 JIA patients, 28 developed confirmed IBD before the age of 18 years: 23 (82.1%) with Crohn disease (CD), 4 (14.3%) with ulcerative colitis (UC), and 1 (3.6%) with IBD-unclassified (IBD-U). The incident rate of IBD during 20 years of observation was 0.56% (0.46% for CD, 0.08% for UC, and 0.02% for IBD-U), of whom 20.3% were HLA-B27 positive, 25% had enthesitis-related arthritis, and 14.3% psoriatic arthritis. Within 90 days before IBD diagnosis, 82.1% (n = 23) received treatment with etanercept (ETA), 39.3% (n = 11) non-steroidal anti-inflammatory drugs, 17.9% (n = 5) systemic corticosteroids, 8 (28.6%) methotrexate (MTX), 14.3% (n = 4) sulfasalazine, 10.7% (n = 3) leflunomide, and 3.6% (n = 1) adalimumab and infliximab, respectively. The incidence of IBD was lower in patients treated with MTX, but higher in patients treated with ETA except if ETA was combined with MTX. Also in patients on leflunomide or sulfasalazine, the IBD incidence was higher. Conclusions: In our JIA cohort, an increased IBD incidence is observed compared to the general population, and the ratio of CD to UC is markedly higher hinting at a distinct phenotype of IBD. Pretreatment with MTX seems to be protective. Treatment with ETA does not prevent IBD development and JIA patients treated with leflunomide and sulfasalazine may be at an increased risk for IBD development.
A low-dose therapy of fibrinogen supplement during perioperative period of total knee arthroplasty in an asymptomatic man with congenital dysfibrinogenemia: A case report

Rationale: Congenital dysfibrinogenemia (CD) is a rare coagulation system disease that is often treated without unified management. Individualized treatment thereof presents clinicians with great challenges. Patient concerns: A patient who was about to undergo total knee arthroplasty was found to have CD. Diagnoses: Coagulation screening revealed low fibrinogen, prolonged thrombin time, minor prolonged prothrombin time, and normal activated partial thromboplastin time were detected during admission, but no abnormal personal and family history findings were observed. Therefore, CD and hypofibrinogenemia were suspected. The gene sequencing confirmed the diagnosis of CD. Interventions: The patient received plenty and low level of fibrinogen concentrate during 2 perioperative periods, respectively. Outcomes: Successful clinical outcomes were obtained using different treatment strategies. Lessons: In contrast to prior case reports, this case illustrates the feasibility of low dosing of fibrinogen supplements within an asymptomatic patient in a selective operation. Changes in the level of fibrinogen and fibrin degradation product are of great importance for individualized treatment after supplementation.
Network dynamics of ongoing social relationships

Many recent large-scale studies of interaction networks have focused on networks of accumulated contacts. In this letter we explore social networks of ongoing relationships with an emphasis on dynamical aspects. We find a distribution of response times (times between consecutive contacts of different direction between two actors) that has a power law shape over a large range. We also argue that the distribution of relationship duration (the time between the first and last contacts between actors) is exponentially decaying. Methods to reanalyze the data to compensate for the finite sampling time are proposed. We find that the degree distribution for networks of ongoing contacts fits better to a power law than the degree distribution of the network of accumulated contacts do. We see that the clustering and assortative mixing coefficients are of the same order for networks of ongoing and accumulated contacts, and that the structural fluctuations of the former are rather large.
Children with Hirschsprung disease in a developing country: A cohort study of the predictors of a positive rectal biopsy result

Chronic constipation, which may be habitually or pathologically caused, is one of the most common complaints in children. One of the important pathological causes is Hirschsprung’s disease (HD), which is diagnosed via multiple modalities, mainly rectal biopsy. Our aim was to compare the presentation and different predictive factors for positive rectal biopsy results in a developing country in the Middle East, such as Jordan. This cohort study was conducted at the Jordan University Hospital (JUH). All consecutive children aged <14 years who presented with refractory constipation and underwent rectal biopsies between January 2014 and December 2019 were retrospectively enrolled in the study. In the entire cohort study, 79 patients were enrolled: 45 (57%) were males and 34 (43%) were females. Regarding the biopsy results, 51 (64.6%) cases of refractory constipation without HD and 28 (35.4%) patients with refractory constipation with HD were diagnosed with open rectal biopsies. The male-to-female ratio of HD patients was 3:1. Moreover, 3 (10.7%) children who passed the meconium within the first 24 to 48 hours showed features of HD, while 17 (60.7%) children with delayed passage of the meconium showed features of HD. Abdominal distension was found to be a positive predictor of positive biopsy results (odds ratio [OR] = 4.09, P = .011), and soiling was found to be a negative predictor of positive biopsy results (OR = 0.07, P = .024). In developing countries, children presenting with HD seem to have similar symptoms and signs to those observed with traditional sampling and staining techniques.
Chemical abundances and gas content in disk galaxies: correlations with the λ spin parameter

By using a very simple and general model to describe the dynamics of disk galaxies, we estimate the λ spin parameter for a sample of observed galaxies and present a study in which we show that several important physical properties are intrinsically related to the dynamics of the systems. Although correlations between average metallicity with magnitude or Hubble type are evident, we obtain equally strong correlations with the spin parameter, where galaxies with low λ values present higher abundances and galaxies with high λ values are poor in metals. Also, the gas content of the galaxies correlates with λ, with high λ systems showing higher gas mass fractions than low λ galaxies, highlighting the important role this parameter plays in the structure of disk galaxies and the proposal of λ as a robust and objective physical measure of galactic morphology.