Miracle-dz/UniFAR-FTUs huggingface dataset:
Surfactant Protein A (SP-A)1 And SP-A2 Differentially Affect F-Actin Levels in The Alveolar Macrophage

And SP-A2 Differentially F-Actin Levels in The Alveolar Abstract Surfactant protein A (SP-A) is an important molecule playing multiple roles in lung innate immunity. SP-A interacts with the alveolar macrophage (AM) and regulates several of its functions. There is increasing evidence that SP-A regulates the AM actin cytoskeleton. Here we used AM from SP-A humanized transgenic mice where each expresses a different human SP-A variant to investigate the impact human SP-A1 and SP-A2 have on F-actin. We found that SP-A2 AM compared to SP-A1 AM: a) exhibit a different pattern of F-actin fluorescence after staining with Alexa Fluor 488 phalloidin and reduced F-actin levels as assessed by measurements of fluorescence per pixel; b) show a lower F-actin to G-actin (F: G) ratio as assessed by Western blot analysis of different cell fractions; and c) have reduced levels of Arp3 protein, as assessed by mining existing relevant proteomics data. Arp3 regulates branched-actin polymerization. These together indicate a differential role of SP-A genetics on the actin cytoskeleton. actin dependent processes, to lung health and disease.
Arthroscopic Posterior Ankle Ligament Anatomy

Background: The purpose of this article is to document the normal arthroscopic appearance of the posterior ankle capsular and ligamentous structures, and variations in their anatomical relationships. Methods: 102 ankle arthroscopy videotapes were evaluated retrospectively for the configuration of the posterior capsuloligamentous structures. Based on these observations, the variations in the appearance and position of the posterior tibiofibular ligament (PTFL) and transverse (tibiofibular) ligament (TTFL) were documented. In addition, differences in the appearance of the flexor hallucis longus (FHL) were also noted. Results: All patients had evidence of both a PTFL and TTFL, which formed a labrum or meniscus-like addition to the posterior distal tibia. No patients demonstrated disruption of the PTFL; 3 had tears of the TTFL. We noted 4 distinct patterns of the PTFL and the TTFL. Thirty-four patients (33%) had a gap of ≥2 mm between the 2 ligamentous structures. Thirty-three (32.4%) had a gap <2 mm between the PTFL and TTFL. Twenty-six (25.5%) had a confluence of the 2 ligaments without a gap. Nine (9%) demonstrated a sizable gap between the 2 ligaments, and the TTFL appeared as a “cord-like” structure. Conclusion: To our knowledge, this is the first article to describe the variations in the arthroscopic normal posterior capsuloligamentous structures and FHL of the ankle. Level of Evidence: Level IV, case series.
Detection of hypotension during spinal anesthesia for caesarean section with continuous non-invasive arterial pressure monitoring and intermittent oscillometric blood pressure monitoring in patients treated with ephedrine or phenylephrine

Introduction/Objective. Despite frequent side effects such as hypotension, spinal anesthesia (SA) is still one of the best anesthetic methods for elective cesarean section (CS). Intermittent, oscillometric, non-invasive blood pressure monitoring (NIBP) frequently leads to the missed hypotensive episodes. Our goal was to compare continuous non-invasive arterial pressure (CNAP) monitoring with NIBP in the terms of efficiency to detect hypotension. Methods. In this study, we compared CNAP and NIBP monitoring for hypotension detection in 76 patients divided into two groups of 38 patients treated with ephedrine (E) or phenylephrine (P), during 3 min intervals, starting from SA, by the end of the surgery. Results. In group E, significantly lower mean systolic blood pressure (SBP) values with CNAP compared with NIBP (p = 0.008) was detected. CNAP detected 31 (81.6%) hypotensive patients in E group and significantly lower number 20 (52.6%) with NIBP (p = 0.001), while in P group CNAP detected 34 patients (89.5%) and NIBP, only 18 (47.3%), p = 0.001. CNAP detected significantly higher number of hypotensive intervals in E and P groups (p < 0.001). Umbilical vein pH was lower within hypotensive compared with normotensive patients in E and P groups, with CNAP and NIBP, respectively (p < 0.001, p = 0.027 in E, and p = 0.009, p < 0.001, in P group). Conclusion. CNAP is much more efficient in hypotension detection for CS during SA, which allows faster treatment of hypotension, thus improving fetal and maternal outcome.
COMPUTER SELF-EFFICACY AND MATH PERFORMANCE IN ADULT BASIC EDUCATION STUDENTS

OF THESIS COMPUTER SELF-EFFICACY AND MATH PERFORMANCE IN ADULT BASIC EDUCATION STUDENTS Domain-specific self-efficacy is increasingly known to be related to student academic performance. This study investigated the relationship between computer and math self-efficacy, math performance, and guided in-class use of an online educational program for adult basic education students enrolled in classes at an adult education program during the 2019 – 2020 school year. Initial math test scores and pre-survey results indicated no statistically significant relationship between computer self-efficacy and math performance, or math self-efficacy and math performance. After attending between 1 and 15 class sessions where an online educational program was used, post-survey results indicated no statistically significant relationship between guided in-class use of an online educational program and computer or math self-efficacy. Initial self-efficacy scores were found to have a negative and statistically significant relationship with changes in selfefficacy scores. These results suggest that further study is required and that students with very low self-efficacy may benefit the most from intervention strategies.
Transdimensional Inversion on the New England Mud Patch Using High-Order Modes

This article presents geoacoustic inversion results for modal-dispersion data collected during the 2017 Seabed Characterization Experiment on the New England Mud Patch, an area where the seabed is characterized by an upper layer of mud. The experiment utilized a combustive sound source and a vertical line array of receivers at 5.4-km range. Using a careful combination of source deconvolution and warping time–frequency analysis, modal dispersion data (arrival time as a function of frequency) are estimated for 18 modes between modes 1 and 21. The modal dispersion data are then used to estimate seabed geoacoustic profiles and uncertainties via transdimensional Bayesian inversion. This article demonstrates the capacity to estimate high-order modes using warping. Comparing inversion results obtained with subsets of (lower order) modes to those obtained with the full set of available modes highlights the rich data information content carried by high-order modes. The results suggest a small sound-speed increase over the first 8 m of the seabed, the upper portion of the mud layer, which some earlier studies found to be isospeed. Overall, the inversion results are consistent with in situ measurements, as well as with previous geoacoustic inversion results.
The Determinants and the Evolution of the Health Policies in Cardiovascular Medicine in a Postmodern Vision

Public health is a scientific domain with significant population impact. Any irregularities or discrepancies affect all patients that depend on its normal function, therefore explaining the reason why public attention is always vastly invested in it. With a balanced health status in the population as primary goal, the domain of public health with its adopted policies stands at the frontlines. Public Health Policies can be resumed to three main aspects, based on the health system performance concept developed by the World Health Organization: population health status, citizen satisfaction with healthcare and the extent to which the system provides financial protection. Nowadays, with cardiovascular disease becoming the leading cause of death worldwide, the field of cardiovascular public health has gained significant general interest. The present article aims to address the importance of health policies from a determinants’ perspective while taking into consideration the influence of population illness on health policy development.
Uncertainty of Tropical Cyclone Wind Radii on Sea Surface Temperature Cooling

The sea surface temperature (SST) beneath a tropical cyclone (TC) is of great importance to its dynamics; therefore, understanding and accurately estimating the magnitude of SST cooling is of vital importance. Existing studies have explored important influences on SST of TC translation speed, maximum surface winds, ocean thermal condition, and ocean stratification. But the influence of the TC wind radii (or collectively called the TC size) on SST has been largely overlooked. In this study, we assess the influence of wind radii uncertainty on SST cooling by a total of 15,983 numerical simulations for the western North Pacific during the 2014–2018 seasons. Results show a 6%–20% SST cooling error induced using wind radii from the Joint Typhoon Warning Center official forecast and a 35%–40% SST cooling error using wind radii from the operational runs of the Hurricane Weather Research and Forecasting (HWRF) model. Our results indicate that SST cooling is most sensitive to the radius of 64 kt winds (R64) due to its effects on the integrated kinetic energy of the TC and subsequent mixing of the ocean surface layer. It is also found that the correlation between SST cooling induced by the TC and its size is 0.49, which is the highest among all the parameters tested. This suggests that it is extremely important to get TC size correct in order to predict the SST cooling response, which then impacts TC evolution in numerical weather prediction models.
Building Cultural Competence and Changing Cultural Perceptions:
 Students from the UAE and USA Participate in a Cultural Exchange
 Project

Objectives: Cultural competence is a skill that is lauded and encouraged in today’s business communication programs and in industry. The problem becomes, how and when do instructors introduce students to meaningful intercultural exchanges that produce the skills and awareness students will need in the future. The instructors in this study wanted a low-cost, student-center program or assignment to introduce students to intercultural communication through actual practice. The project needed to help students become more culturally aware and culturally competent. Methods: The authors of this study paired their students for a virtual cross-cultural exchange for a period of 8 weeks. Students from the United States of America (USA) and the United Arab Emirates (UAE) spent several weeks corresponding via the text messaging application, WhatsApp, in order to learn more about the other’s culture and customs. Surveys intended to measure cultural awareness and cultural competence were taken by students prior to the start of the exchange and again at its conclusion. Results: The survey results show an increase in cultural awareness and cultural competence correlated to the cultural exchange project. Conclusions: Instructors can create low-cost, interactive opportunities for students to improve cultural awareness and competence through online conversations and cultural exchanges with students of various cultures in different locales and countries.
Benthic oxygen fluxes in a coastal upwelling system (Ria de Vigo, NW Iberia) measured by aquatic eddy covariance

Organic carbon mineralization and nutrient cycling in benthic environments are critically important for their biogeochemical functioning, but are poorly understood in coastal upwelling systems. The main objective of this study was to determine benthic oxygen fluxes in a muddy sediment in the Ria de Vigo (NW Iberian coastal upwelling), by applying the aquatic eddy covariance (AEC) technique during 2 campaigns in different seasons (June and October 2017). The main drivers of benthic fluxes were studied and compared among days in each season and between seasons. The 2 campaigns were characterized by an upwelling-relaxation period followed by a downwelling event, the last of which was due to the extratropical cyclone Ophelia in October. The mean (±SD) seasonal benthic oxygen fluxes were not significantly different for the 2 campaigns despite differences in hydrodynamic and biogeochemical conditions (June: -20.9 ± 7.1 mmol m-2 d-1 vs. October: -26.5 ± 3.1 mmol m-2 d-1). Benthic fluxes were controlled by different drivers depending on the season. June was characterized by sinking labile organic material, which enhanced benthic fluxes in the downwelling event, whereas October had a significantly higher bottom velocity that stimulated the benthic fluxes. Finally, a comparison with a large benthic chamber (0.50 m2) was made during October. Despite methodological differences between AEC and chamber measurements, concurrent fluxes agreed within an acceptable margin (AEC:benthic chamber ratio = 0.78 ± 0.13; mean ± SD). Bottle incubations of water sampled from the chamber interior indicated that mineralization could explain this difference. These results show the importance of using non-invasive techniques such as AEC to resolve benthic flux dynamics.
Improving genomic evaluation strategies in dairy cattle through SNP pre-selection

The availability of the 54K SNP array has considerably changed the landscape of selection in dairy cattle. We are now able to use genomic prediction instead of pedigree-based genetic evaluations in selection programs. To perform genomic selection, various methods have been proposed with more or less success depending on the trait, the breed, the training population size. In this paper, we investigate three different genomic evaluation methods: (i) the Genomic BLUP where the effect of each SNP is estimated by BLUP (Best Linear Unbiased Prediction) assuming known variances. (ii) the Elastic Net algorithm (EN), a variable reduction method. (iii) the Partial Least Squares algorithm which projects dependent variables onto a new space of lower dimension. EN and PLS were developed especially to solve the p>>n problem (very large number of dependent variables compared to the number of individuals). These three methods were compared to pedigree-based BLUP. In a second step, we show how one can successfully improve the accuracy of the equation of prediction, whatever the method used, using pre-selection of the SNP based on results from QTL detection by linkage disequilibrium-linkage analysis.
Mixed Matrix Membranes for Water Purification Applications

Membrane technology has been utilized for water purification application for a long time. Both polymeric and ceramic membranes have been center of interest for their tremendous contribution in this area. Despite their advantages, these synthetic membranes have limitations in terms of performance and durability. To meet the new demands and standards, mixed matrix membranes (MMM) have gained serious importance due to their ability to combine the features of the aforementioned membrane materials, offering better solutions in terms of performance, fouling, permeate quality and longevity. Besides such attractive features, MMMs have not yet reached sufficient maturity to challenge conventional membranes commercially. This review categorizes MMMs on its filler basis into four types; (i) inorganic filler-based MMMs, (ii) organic filler-based MMMs, (iii) biofillers-based MMMd, and (iv) hybrid filler-based MMMs. A discussion is extended to modules and cost of these membranes along with the specific applications of each type of fillers. It also identifies the issues and challenges in the MMM area and highlights the domains that remain to be investigated.
The influence of eWOM on the use of mobile banking

Ovaj rad se nadovezuje na istraživanje [20] i ispituje uticaj eWOM komunikacije na faktore kao što su socijalne norme, početno poverenje, uočena korisnost, jednostavnost upotrebe, stav i namera korišcénja mobilnog bankarstva na teritoriji Srbije. Anketa je sprovedena pomoću onlajn i oflajn upitnika koji je popunio 501 ispitanik. Analiza je izvršena pomocú alata SPSS22 i AMOS22, gde je model strukturne jednačine (SEM) korišcén za testiranje direktnog uticaja eWOM komunikacije na društvenim mrežama na stavove i namere klijenata da koriste usluge mobilnog bankarstva. Kao odgovor na problem pronašli smo skup faktora koji utiču na stav i nameru klijenata da koriste mobilno bankarstvo, što menadžeri mogu naglasiti prilikom kreiranja marketinške strategije.
Speciation of Uranium in Gorleben Groundwaters

The Sorption behavior of the UOi"^ ion onto humic colloids in one of the Gorleben groundwaters (Gohy-2227) is investigated at different CO2 partial pressures from pH 1 to pH 10 by ultrafiltration and anion exchange. From pH 1 to pH 4 the Sorption of the UOi"^ ion increases with pH. Desorption occurs above pH 4.5 and is contingent upwn the CO2 partial pressure. Based on the experimental results and literature data, the thermodynamic stability constant for the temary complex of uranylhydroxohumate is found as log^ (U02(0H)HA) = 14.7 ± 0.5 Speciation of natural uranium in five Gorleben groundwaters is performed by ultrafiltration and the results are compared to the thermodynamic calculation for U(VI). A large discrepancy is found. Over 75% of the natural uranium is colloid-bome, while the calculation predicts less than 1% of U(VI) to be in humic colloids. This fact and the low groundwater Eh suggest that much of the uranium in the examined Gorleben groundwaters appears to be in the tetravalent oxidation State.
Development of Social Media Analytics System for Emergency Event Detection and Crisis Management

Social media platforms have proven to be effective for information gathering during emergency events caused by natural or human-made disasters. Emergency response authorities, law enforcement agencies, and the public can use this information to gain situational awareness and improve disaster response. In case of emergencies, rapid responses are needed to address victims' requests for help. The research community has developed many social media platforms and used them effectively for emergency response and coordination in the past. However, most of the present deployments of platforms in crisis management are not automated, and their operational success largely depends on experts who analyze the information manually and coordinate with relevant humanitarian agencies or law enforcement authorities to initiate emergency response operations. The seamless integration of automatically identifying types of urgent needs from millions of posts and delivery of relevant information to the appropriate agency for timely response has become essential. This research project aims to develop a generalized Information Technology (IT) solution for emergency response and disaster management by integrating social media data as its core component. In this paper, we focused on text analysis techniques which can help the emergency response authorities to filter through the sheer amount of information gathered automatically for supporting their relief efforts. More specifically, we applied state-of-the-art Natural Language Processing (NLP), Machine Learning (ML), and Deep Learning (DL) techniques ranging from unsupervised to supervised learning for an in-depth analysis of social media data for the purpose of extracting real-time information on a critical event to facilitate emergency response in a crisis. As a proof of concept, a case study on the COVID-19 pandemic on the data collected from Twitter is presented, providing evidence that the scientific and operational goals have been achieved. © 2021 Tech Science Press. All rights reserved.
A nanogel with passive targeting function and adjustable polyplex surface properties for efficient anti-tumor gene therapy

Non-cytotoxic vectors with high transfection efficiency and serum stability play a key role for successful gene delivery, which is strongly determined by polyplex structural properties and cellular affinity. In this study, through modifying the “gold-standard” transfection agent poly(ethylenimine) (PEI) with non-cytotoxic monomer N-isopropylacrylamide (NIPAM), we successfully developed a thermosensitive cationic PNIPAM/PEI nanogel. It has a crosslinked thermosensitive core and cationic shell with adjustable dimensions, surface potential and passive cellular targeting function. The polyplex properties such as size, surface potential, thermo-sensitivity and serum stability of the nanogel was systemically investigated by laser light scattering. It was found that the in vitro transfer efficiency by the nanogel was about two times higher than that of PEI, which was further enhanced about two time as T > VPTT due to the passive cellular targeting. The obviously enhanced in vitro cellular uptake, gene transfer efficiency and corresponding mechanism of the nanogel were then revealed by inverse fluorescent microscopy, a flow cytometer and confocal laser scanning microscopy. Its biodistribution and high intratumor accumulation were also evaluated in a Balb/c nude mice xenograft tumor model. Such a sophisticated nanogel significantly suppressed tumor growth with a volume 5 times smaller than that of PEI, which indicated its high potent for practical gene therapy.
Psychiatric Evaluation of the Effects of COVID-19

The current COVID-19 pandemic has hit the entire world population hard and it is assumed that its consequences on mental health will be as important as its current physical repercussions. However, the evidence on this is not yet well known and it may be too early to assess these consequences. Objective: Identify if mental health has been worst in 2020 than 2018 and 2019. Descriptive study using artificial intelligence and natural language processing savana manager program in a population of 3,000,000 inhabitants. Results: Psychopathological diagnoses and prescription of psychotropic drugs have not changed significantly in the last year.
The Impact of Cross-Industry Pollution, Consumer Environmental Awareness, and Corporate Social Responsibility on Industrial Environmental Policies

In this paper, I established a cross-industry pollution externality design and used the three-stage game analysis framework to discuss the issues linked to firm output, labor union negotiation wages, and the government’s optimal environmental tax. We show that with environmentally oriented corporate social responsibility, the government’s optimal environmental tax rate and firms’ residual pollution abatement level will decrease, which is conducive to environmental protection, and the negotiated wages of all firms will increase. With environmentally oriented corporate social responsibility, the profits and union utility of industry firms will increase, as will the overall consumer surplus and the social welfare level, but there will be no effect on the profit and union utility of firms whose productivity is reduced by pollution.