Miracle-dz/UniFAR-FTUs huggingface dataset:
Reference evapotranspiration during rainy and dry seasons in Mossoró, RN, Brazil

Mossoro, RN, Brazil, is considered one of the fruit growing centers of the Northeast region. This municipality has a persistent water deficit, with the need to develop irrigated agriculture with efficient water use and rational management of irrigation. The objective of this study was to evaluate estimation methods of reference evapotranspiration (ETo) for different climate conditions of Mossoro, comparing them with the standard Penman-Monteith-FAO 56 method. A daily data series of two distinct years, a rainy (2011) and a dry year (2012), was used. The data were obtained from the weather station of the Federal Rural University of the Semi-Arid Region (UFERSA). An analysis was performed to identify methods that best fit those of Penman-Monteith-FAO 56, and for this, ten methods were evaluated using statistical indices. The Penman-Original, Radiation-Temperature, and Hargreaves-Original methods stood out and satisfactorily met ETo estimation for the rainy season, while the Jensen-Haise, Radiation-Temperature, and Hargreaves-Original methods achieved satisfactory performance for the dry season. The Hargreaves-Samani method did not demonstrate viability in the use of ETo estimation, as it was the worst method in both studied periods and is not recommended for irrigation management.
Mapping Urban Networks through Inter-Firm Investment Linkages: The Case of Listed Companies in Jiangsu, China

Recently, literature on urban network research from the perspective of firm networks has been increasing. Focusing on firms’ multi-location distribution, existing studies use mainly the internal organization structural information of firms to portray one-type industry or all-industry networks, and there are deficiencies in reflecting the authenticity of networks and comparing the differences across industries. In contrast to studies applying intra-firm networks, this study collects real investment data of all listed firms in Jiangsu Province and studies urban networks through quantifying inter-firm linkages. Based on inter-firm investment linkages, this study provides fresh insights on inter-city connections in China. The results show that Nanjing, Suzhou, Shanghai, Beijing and Shenzhen are the constant network centers across different industries. Particularly, Shenzhen has been favored by more investment inflows far beyond its GDP. In China’s unique institutional context, state power, geographical location, market and other factors jointly affect the flow of investment, and the role of state power deserves special attention. Since real economic connections are used to describe urban networks, the findings might contribute to ongoing debates regarding economic centers in China and bring further implications for policy making in investment environment improvement. It enriches the research of urban networks based on real inter-firm connections, and provides ideas for the wider regional study and the combination of econometric techniques and social network analysis.
Drug-induced liver injury (DILI) Amoxicillin-clavulanic acid HLA-DRB1*15:02 Major Histocompatibility Complex (MHC) Peptide-binding groove diagnostic genotyping Word count: 3458 Figures: 2 Tables: 2 Key Points: 1) Candidate gene and genome-wide association studies (GWAS) in well characterized cases h

1 Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433 2 NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK. 3 Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK. 4 The Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK 5 Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Disability Insurance and Gender Differences: Evidence from Merged Survey-Administrative Data∗

Using HRS data matched with Social Security administrative data, we document large gender differences in disability insurance programs admission rates and type I error rates. In particular, women who apply for DI/SSI are 13 percentage point less likely to be awarded benefits than men, controlling for health, occupation and a host of demographic characteristics. Moreover, women who self-report to be disabled are 20 percentage points more likely to be rejected than observationally similar men. We investigate whether these gender differences can be explained by heterogeneity in underlying unobserved health, differences in disability perceptions, higher noise-to-signal ratios, or SSA evaluators’ assessment bias. We find little support for the first three explanations, and some indirect support for the latter.
The Effects of Step versus Jump Forward Lunge as Single Exercise Training on Badminton Specific Physical Abilities

This study was conducted to determine and compare the effects of step versus jump forward lunge training on badminton specific physical abilities. Thirty recreationally active badminton players (mean age = 22.07 ± 1.39 years old) were recruited and divided into three groups; i) step forward lunge (SFL), jump forward lunge (JFL) and control group (CG). Lunge one repetition maximum (1RM), lunge relative 1RM, vertical jump, standing broad jump and change of direction (COD) t-test were tested preand posteight weeks of training intervention. Results showed both treatment groups (SFL and JFL) had improved significantly in all tests. JFL was shown to have significantly greater improvement in lunge 1RM, lunge relative 1RM, vertical jump, and standing broad jump compared to SFL. Results demonstrated the superiority of JFL training compared to SFL in enhancing badminton specific physical abilities. However practitioners still advised to start their program with SFL and proceed to JFL after certain period of time. This is due to high contraction velocity nature of JFL which might have higher risk of injury if performed without sound strength basis.
Character-Based Tactical Learning Model for Strengthening Characters in Sports Physical Education (PJOK) of 5th Graders Elementary Schools

In Indonesia there is a problem of a growing moral crisis, as a negative impact of ICT developments and globalization. Cases such as student fights, free sex, alcoholism, mass brawls, thuggery, corruption, drugs, almost every day are reported on TV and in print media. The crisis comes from moral which is related to educational practice. Therefore, it is appropriate to restore the values that have been taught by the nation's founders. PJOK subjects as one of the subjects in elementary school, must be able to develop character values, such as friendliness, caring, cooperation, discipline, honesty, sportsmanship, and responsibility. One of the PJOK learning models that are in accordance with constructivism theory and according to the age of development of children is the Tactical learning model. Character-based Tactical Learning is expected to strengthen and build the character of students according to national character values.
An overview of sepsis

Sepsis is an important clinical problem particularly in intensive care units. Although sepsis can be triggered by almost all microorganisms, risk of septic shock and mortality rate are higher in Gram negative bacteremia. In this mini review, role of tumor necrosis factor and other mediators in sepsis and new therapeutic approaches such as therapy with monoclonal antibodies have been discussed.
Eradication Treatment of Helicobacter pylori Infection Based on Molecular Pathologic Antibiotic Resistance

Background Unfortunately, the eradication rate of Helicobacter pylori (H. pylori) treatment is markedly decreasing in recent years and the major reason is antibiotic resistance. Our study was designed to determine the effect and safety of H. pylori eradication treatment based on the molecular pathologic antibiotic resistance. Methods 261 patients were analyzed retrospectively, including 111 patients who were treated for the first time (one group as First-treated) and 150 patients who failed at least once in bismuth quadruple therapy (another group as Re-treatment). Antibiotic resistance was examined by Real-time PCR detection and conventional PCR and sequencing method. The eradication rate (ER) was compared per intention to treat (ITT) and per protocol (PP) between the two groups. Results The resistance rates to amoxicillin, clarithromycin, fluoroquinolone and tetracycline were 5.5%, 42.1%, 41.7% and 12.9% in the 111 first-treated patients, and 11.7%, 79.7%, 70.7% and 30.0% in the 150 re-treatment patients. The ERs in the ITT and PP analyses were 92.79% (95% CI, 87.98–97.60%, n=111) and 98.10% (95% CI, 95.48–100%, n=105), respectively, in the first-treated patients and 90.67% (95% CI, 86.01–95.32%, n=150) and 95.10% (95% CI, 91.57–98.64%, n=143), respectively, in the re-treatment patients. No significant differences were shown in the ERs between two group patients, and no serious adverse events were found. Conclusion H. pylori eradication treatment based on molecular pathologic antibiotic resistance showed good effect and safety in both first and re-treated patients.
An assessment of Chromogenic Agar Medium and Conventional Culture System for the Isolation of Uropathogens

Original Research Article Introduction: Urinary tract infections (UTI) account for significant health burden among all age groups. Isolation and identification of the uropathogens by bacterial culture and selection of appropriate antimicrobial drugs through susceptibility testing is the mainstay in management of UTI cases. Material & Methods: This was a cross-sectional study which was carried out in the Department of Microbiology, Rajshahi Medical College (RMC) to evaluate the performance of a Chromogenic agar medium (commercially named as HiCrome UTI agar) and conventional culture system like Blood agar (BA) and MacConkey (MAC) agar for isolation and presumptive identification of the uropathogens. Results: Slightly higher bacterial growth was noted among female (29.33%) than male (17.00%) patients as a whole and 15-45 years was the leading age group with higher number of culture positive cases. Out of 300 urine samples cultured, a total of 139 (46.33%) yielded bacterial growth and 161 (53.67%) were negative for bacterial growth. Bacterial isolates included E. coli 91(62.75%), Klebsiella spp. 18(12.41%), Enterococcus spp. 16(11.03%), Pseudomonas spp. 09(06.28%), Staph. saprophyticus 05(3.44%), Enterobactor spp. 04(2.75%) and Proteus spp. 02(1.37%). It is evident from the present study that both HiCrome UTI agar and BA media supported growth of all 145 bacteria, while MAC agar yielded 133(91.72%) bacterial growths. The rate of presumptive identification of the isolates was found significantly higher (97.24%) on HiCrome UTI agar when compared with the MacConkey agar (80.68%) and Blood agar (27.58%) media. In antimicrobial susceptibility testing, majority of the isolates showed very high (78% -100%) sensitivity to Imipenem. Ceftazidime and Cefuroxime were also found efficacious against E. coli and Staph. saprophyticus, while Klebsella spp. , Enterococcus spp. , Pseudomonas spp. , Enterobacter spp. and Proteus spp. showed variable sensitivity to these drugs. Further, most of the isolates showed moderate to poor sensitivity to Ciprofloxacin, Nalidixic acid, Cephalexin, Amoxicillin and Cotrimoxazole. (Minimize that red mark) Conclusion: HiCrome UTI agar can be recommended as primary urine culture medium to be used by the clinical microbiology laboratories.
Sialylation of FGFR1 by ST6Gal-I overexpression contributes to ovarian cancer cell migration and chemoresistance

Fibroblast growth factor receptors (FGFRs) have been implicated in the malignant transformation and chemoresistance of epithelial ovarian cancer; however, the underlying molecular mechanisms are poorly understood. Increased sialyltransferase activity that enhances protein sialylation is an important post-translational process promoting cancer progression and malignancy. In the present study, α2,6-sialyltransferase (ST6Gal-I) overexpression or knockdown cell lines were developed, and FGFR1 was examined to understand the effect of sialylation on migration and drug resistance, and the underlying mechanisms. It was identified that cells with ST6Gal-I overexpression had increased cell viability and migratory ability upon serum deprivation. Moreover, ST6Gal-I overexpression cells had strong resistance to paclitaxel, as demonstrated by low growth inhibition rate and cell apoptosis level. A mechanistic study showed that ST6Gal-I overexpression induced high α2,6-sialylation of FGFR1 and increased the expression of phospho-ERK1/2 and phospho-focal adhesion kinase. Further study demonstrated that the FGFR1 inhibitor PD173047 reduced cell viability and induced apoptosis; however, ST6Gal-I overexpression decreased the anticancer effect of PD173047. In addition, ST6Gal-I overexpression attenuated the effect of Adriamycin on cancer cells. Collectively, these results suggested that FGFR1 sialylation plays an important role in cell migration and drug chemoresistance in ovarian cancer cells.
Positive Massage for Couples’ Wellbeing and Relationships: The Bridge between Positive Psychology and Massage

Although positive psychology interventions are generally aimed at individuals, when considering couples, a dyadic approach may be more effective. In terms of a couples’ wellbeing, their relationship is one of the most important factors. As such, interventions targeted for both members’ wellbeing via their relationship are likely to be of value. Currently, there exist limited dyadic positive activity interventions available in positive psychology, and notably, tactile intervention is lacking. Massage is the evidence based tactile health modality that has long history as a therapeutic intervention, as well as being one of the most natural human health-oriented behaviours. The current commentary argues for the link between positive psychology and massage, and that “Positive Massage” can be a bridge between the hitherto distinct entities of positive psychology and massage. Furthermore, based on the conceptual theoretical model of the link between Positive Massage and wellbeing, we propose that Positive Massage can be an effective positive intervention impacting on couples’ wellbeing and enhancing their relationships.
Increased levels of mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2-R) found in serum of patients with breast cancer

The multifunctional transmembrane mannose-6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2-R) has been proposed as a putative prognostic marker in breast cancer. Loss of heterozygosity (LOH) with mutations in the remaining allele have been described at the gene level. We previously reported significant decrease of M6P/IGF2-R at the protein level in cancer cells than normal peritumoral ducts of breast tumors which may indicate an increased release of the receptor from the cell membrane to the blood. To assess that hypothesis we measured in this study M6P/IGF2-R levels in serum of women with breast cancer by competitive enzyme-linked immunosorbent assay (ELISA) that allows a detectable sensitivity of 300 ng/mL. The results were obtained referring to a standard curve consisting in varying concentrations of human purified M6P/IGF2-R. Women sera consisted of cancer-free sera (n=39) or serum from women with breast cancer (n=39) were preincubated with anti-M6P/IGF2-R immunoglobulin Y (IgY) antibodies. High levels of M6P/IGF2-R (p<0.01) were found in serum from women with breast cancer in comparison with cancer-free serum. Overall the results support the hypothesis of increased release of the receptor from cancer cells to the blood and add one more argument for M6P/IGF2-R studying as a potential breast cancer marker. Key words: Mannose-6-Phosphate/Insulin-like Growth Factor-2 Receptor (M6P/IGF2-R), loss of heterozygosity (LOH), suppressor gene, breast cancer, competitive enzyme-linked immunosorbent assay (ELISA), IgY, biological marker.
Towards a Lightweight Detection System for Cyber Attacks in the IoT Environment Using Corresponding Features

The application of a large number of Internet of Things (IoT) devices makes our life more convenient and industries more efficient. However, it also makes cyber-attacks much easier to occur because so many IoT devices are deployed and most of them do not have enough resources (i.e., computation and storage capacity) to carry out ordinary intrusion detection systems (IDSs). In this study, a lightweight machine learning-based IDS using a new feature selection algorithm is designed and implemented on Raspberry Pi, and its performance is verified using a public dataset collected from an IoT environment. To make the system lightweight, we propose a new algorithm for feature selection, called the correlated-set thresholding on gain-ratio (CST-GR) algorithm, to select really necessary features. Because the feature selection is conducted on three specific kinds of cyber-attacks, the number of selected features can be significantly reduced, which makes the classifiers very small and fast. Thus, our detection system is lightweight enough to be implemented and carried out in a Raspberry Pi system. More importantly, as the really necessary features corresponding to each kind of attack are exploited, good detection performance can be expected. The performance of our proposal is examined in detail with different machine learning algorithms, in order to learn which of them is the best option for our system. The experiment results indicate that the new feature selection algorithm can select only very few features for each kind of attack. Thus, the detection system is lightweight enough to be implemented in the Raspberry Pi environment with almost no sacrifice on detection performance.
A Global Climatological Model of 2 Extreme Geomagnetic Field 3 Fluctuations 4

This paper presents a multi-parameter global statistical model of extreme horizontal geomagnetic field 10 fluctuations (dBH/dt), which are a useful input to models assessing the risk of geomagnetically induced currents in ground 11 infrastructure. Generalised Pareto (GP) distributions were fitted to 1-minute measurements of |dBH/dt| from 125 12 magnetometers (with an average of 28 years of data per site) and return levels (RL) predicted for return periods (RP) between 13 5 and 500 years. Analytical functions characterise the profiles of maximum-likelihood GP model parameters and the derived 14 RLs as a function of corrected geomagnetic latitude, λ. A sharp peak in both the GP shape parameter and the RLs is observed 15 at |λ| =53° in both hemispheres, indicating a sharp equatorward limit of the auroral electrojet region. RLs also increase 16 strongly in the dayside region poleward of the polar cusp (|λ|>75°) for RPs > 100 years. We describe how the GP model may 17 be further refined by modelling the probability of occurrences of |dBH/dt| exceeding the 99.97th percentile as a function of 18 month, magnetic local time, and the direction of the field fluctuation, dBH, and demonstrate that these patterns of 19 occurrence align closely to known patterns of auroral substorm onsets, ULF Pc5 wave activity, and (storm) sudden 20 commencement impacts. Changes in the occurrence probability profiles with the interplanetary magnetic field (IMF) 21 orientation reveal further details of the nature of the ionospheric currents driving extreme |dBH/dt| fluctuations, such as 22 the changing location of the polar cusp and seasonal variations explained by the Russell-McPherron effect. 23
Stress and coping strategies of medical students during their first clinical practice – a pilot study

Introduction: The medical profession is acknowledged as one of the most stressful. The time devoted to acquire knowledge and practical skills is a source of stress for students, but also an opportunity to learn how to deal with it. Aim of the research: To assess how medical students deal with stress during their first clinical practice. Material and methods: The study was conducted in a group of 526 students of: nursing, physiotherapy, medical rescue, and obstetrics at a university. The research tools included: an original questionnaire, the Perceived Stress Scale, and the Stress Management Inventory. The dependence between variables was established using the Spearman’s rank correlation. A signifi- cance level of α = 0.05 was assumed in the tests. Results: Almost half of the students experienced high levels of stress, and more than half of them manifested high levels of self-efficacy. The participants dealt with difficult situations mainly by active coping, planning, and seeking instrumental support. The paramedics and the midwives more often turned to active coping than did the physiotherapists. Younger people were more inclined to choose strategies associated with seeking support (rho = –0.134, p = 0.001). It was shown that strategies of managing difficult situations based on helplessness were more often followed by older people (rho = 0.126, p = 0.002). The greater sense of self-efficacy in the participants, the more often they chose active stress coping strategies. Conclusions: Active stress management strategies should be developed in students also to strengthen their sense of self- efficacy.
Optimal Expectations and Limited Medical Testing: Evidence from Huntington Disease

We use novel data to study the decision to undergo genetic testing by individuals at risk for Huntington disease (HD), a hereditary neurological disorder that reduces healthy life expectancy to about age 50. Although genetic testing is perfectly predictive and carries little financial or time cost, less than 10 percent of at-risk individuals are tested prior to the onset of symptoms. Testing rates are higher for individuals with higher ex ante risk of carrying the genetic expansion for HD. Untested individuals express optimistic beliefs about their probability of having HD and make fertility, savings, labor supply, and other decisions as if they do not have HD, even though individuals with confirmed HD behave quite differently. We show that these facts are qualitatively consistent with a model of optimal expectations (Brunnermeier and Parker, 2005) and can be reconciled quantitatively in this model with reasonable parameter values. This model nests the neoclassical framework and, we argue, provides strong evidence rejecting the assumptions of that framework. Finally, we briefly develop policy implications.