Miracle-dz/UniFAR-FTUs huggingface dataset:
Response: Commentary: Bullous pemphigoid associated with COVID-19 vaccines: An Italian multicenter study

COPYRIGHT © 2023 Pira, Moltrasio, Abeni, Corrà, Marzano, Caproni and Di Zenzo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Response: Commentary: Bullous pemphigoid associated with COVID-19 vaccines: An Italian multicenter study
Random Cycle Loss and Its Application to Voice Conversion

Speech disentanglement aims to decompose independent causal factors of speech signals into separate codes. Perfect disentanglement benefits to a broad range of speech processing tasks. This paper presents a simple but effective disentanglement approach based on cycle consistency loss and random factor substitution. This leads to a novel random cycle (RC) loss that enforces analysis-and-resynthesis consistency, a main principle of reductionism. We theoretically demonstrate that the proposed RC loss can achieve independent codes if well optimized, which in turn leads to superior disentanglement when combined with information bottleneck (IB). Extensive simulation experiments were conducted to understand the properties of the RC loss, and experimental results on voice conversion further demonstrate the practical merit of the proposal. Source code and audio samples can be found on the webpage http://rc.cslt. org.
ASSESSMENT OF INDOOR NON-IONISING RADIATION OF SELECTED RESIDENTIAL APARTMENTS IN GOMBE METROPOLIS, GOMBE STATE, NIGERIA

A cross sectional design approach was employed to assess the indoor radiation exposure of population in selected residential apartments in Gombe Metropolis, Gombe State Nigeria. Primary data was obtained aided by a hand-held radiation meter and a well-structured questionnaire. With the aim of ascertaining the radiation distribution pattern and occurrence rate of Electro Hypersensitivity Syndrome’ (EHS) in the study area. The analysis of variance test ‘ANOVA’, an inferential statistics was used to ascertain the radiation distribution pattern, while the descriptive statistics was used in determining the occurrence rate of (EHS) inpopulations of the study area. A convenience sampling technique was adopted, and 30 sampling unit of residential apartment were chosen for the study, relying on homogeneity, inclusion and exclusion criteria. The pre-tested questionnaire scored 74% Cronbach's Alfa reliability. Findings from the study revealed that total indoor radiation varied significantly across the study area, with F(2,27) = 38.599, P < 0.00, at (α = 0.05). The occurrence rate of the understudied EHS illnesses were determined to be in the following order: sleep disorder, fatigues, headaches, dizziness, loss of appetite and memory loss, with mean averages of 3.53,3.26, 2.97, 2.70, 2.17, and 2.03 respectively. Hence a recommendation for public sensitization on the occurrence, effect and necessary policy control measures, towards minimising public exposure to indoor non-ionising radiation, by relevant stakeholders such as: the Standards Organisation of Nigeria, Federal and States Ministries of Environment and the Nigerian Customs was necessitated.
Clustered Microcalcification Detection Based on Multiple Kernel Support Vector Machine with Grouped Features

The features of microcalcification and normal breast tissue are heterogeneous in the region of interest which is always ignored in recent research.A multiple kernel SVM based on grouped features was proposed to tackle with this problem.The prior knowledge from difference resource were grouped and then combined into the framework of multiple kernel SVM based classification scheme.And a multiple kernel SVM could be formulated into a semi-definite programming (SDP),then the weight value of different kernel matrix could be computed via the SDP.Active feedback learning was used in the training sample selection.The experimental results demonstrate that GF-SVM achieves the best performance compared with different kinds of traditional single kernel SVM.
Regulation of Cell Plasticity by Bromodomain and Extraterminal Domain (BET) Proteins: A New Perspective in Glioblastoma Therapy

BET proteins are a family of multifunctional epigenetic readers, mainly involved in transcriptional regulation through chromatin modelling. Transcriptome handling ability of BET proteins suggests a key role in the modulation of cell plasticity, both in fate decision and in lineage commitment during embryonic development and in pathogenic conditions, including cancerogenesis. Glioblastoma is the most aggressive form of glioma, characterized by a very poor prognosis despite the application of a multimodal therapy. Recently, new insights are emerging about the glioblastoma cellular origin, leading to the hypothesis that several putative mechanisms occur during gliomagenesis. Interestingly, epigenome dysregulation associated with loss of cellular identity and functions are emerging as crucial features of glioblastoma pathogenesis. Therefore, the emerging roles of BET protein in glioblastoma onco-biology and the compelling demand for more effective therapeutic strategies suggest that BET family members could be promising targets for translational breakthroughs in glioblastoma treatment. Primarily, “Reprogramming Therapy”, which is aimed at reverting the malignant phenotype, is now considered a promising strategy for GBM therapy.
Effects of Dietary Vegetable Oil Mixtures including Soybean Oil on Intestinal Oxidative Stress in Gilthead Sea Bream (Sparus aurata)

Simple Summary Vegetable oil inclusion in fish diets is a common practice, but their effects in the oxidative status at intestinal level, which would affect animal health and welfare, are poorly understood. In the present study, we compared the effects of different dietary treatments containing soybean oil alone or in combination with other vegetable oils in sea bream. Overall, the results revealed that the blend of soybean and linseed oils negatively affects intestinal integrity as it triggered high oxidative stress that could not be counteracted by the high levels of antioxidant enzymes. However, the addition of palm oil to the previous mixture of vegetable oils makes it possible to maintain low oxidative stress, preserving the intestinal health of the animal. In conclusion, this study demonstrates the importance that the mixture of vegetable oils in a diet can have on the intestinal health of sea bream. Abstract Fish oil is commonly replaced by vegetable oils in sea bream diets, but little is known about their effects on intestinal health regarding oxidative stress biomarkers. The negative effects of lipid peroxidation on digestive mucosa could have consequences in animal nutrition and welfare. In this study, five isonitrogenous (46%) and isolipidic (22%) diets with 75% of vegetable oils inclusion were evaluated: soybean oil (S) alone or different mixtures containing soybean oil with linseed (SL), linseed and rapeseed (SLR), linseed and palm (SLP), and linseed, rapeseed, and palm (SLRP). Gilthead sea bream juveniles were fed twice a day for 18 weeks. Pyloric caeca and proximal intestine samples were collected 24 h post feeding for lipid peroxidation (LPO), antioxidant enzyme activities (SOD, CAT, GPx, GST, and GR) and gene expression analyses. Pyloric caeca presented larger unhealthy changes in oxidative status than proximal intestine. Although SL-fed fish showed the highest antioxidant activities, they were unable to cope with LPO that in pyloric caeca was 31.4 times higher than in the other groups. Instead, SLP fish presented the best oxidative status, with low LPO levels, antioxidant enzyme activities, and gene expression. In summary, between the vegetable oils dietary mixtures tested, SPL would maintain better intestinal health.
A level set characteristic Galerkin finite element method for free surface flows

This paper presents a numerical method for free surface flows that couples the incompressible Navier–Stokes equations with the level set method in the finite element framework. The implicit characteristic‐Galerkin approximation together with the fractional four‐step algorithm is employed to discretize the governing equations. The schemes for solving the level set evolution and reinitialization equations are verified with several benchmark cases, including stationary circle, rotation of a slotted disk and stretching of a circular fluid element. The results are compared with those calculated from the level set finite volume method of Yue et al. (Int. J. Numer. Methods Fluids 2003; 42:853–884), which employed the third‐order essentially non‐oscillatory (ENO) schemes for advection of the level set function in a generalized curvilinear coordinate system. The comparison indicates that the characteristic Galerkin approximation of the level set equations yields more accurate solutions. The second‐order accuracy of the Navier–Stokes solver is confirmed by simulation of decay vortex. The coupled system of the Navier–Stokes and level set equations then is validated by solitary wave and broken dam problems. The simulation results are in excellent agreement with experimental data. Copyright © 2005 John Wiley & Sons, Ltd.
Compact microstrip diplexer design using new octagonal resonators for 5G and Wi-Fi applications

The present paper sheds light on designing a new and high performance microstrip diplexer. The latter is based on new octagonal meandrous resonators combined with the connected common port, without adding any transmission line junction, in order to get a miniaturized structure. The suggested compact resonator is formed through combining the octagonal meandrous lines and coupled lines, which create a bandpass filter. These filters operate at 3.5 GHz and 5 GHz which make them suitable for 5G and Wi-Fi applications. Accordingly, an approximated equivalent LC model of the presented octagonal meandrous resonator is suggested and analyzed so as to validate the simulation results. On top of that, the suggested diplexer is compact, as it occupies only 0.0768 λ g × 0.024 λ g. Thus, it attained excellent performance in terms of S-Parameters as the transmission coefficients are about -1 dB and the reflection coefficient is about -20 dB at both channels, whereas the isolation is about -25 dB. Hence, the validation of theoretical and simulated results is carried out through measurements of the manufactured prototype.
Electron dynamics of molecular frustrated double ionization driven by strong laser fields

We theoretically investigate the frustrated double ionization (FDI) of molecules with different alignment-dependence using a three-dimensional classical ensemble method. The numerical results show that the FDI probability decreases with increasing wavelength, which is similar to the wavelength dependence of the FDI probability of atoms. Tracing the classical trajectories reveals that the contributions to molecular FDI from single-recollision and multiple-recollision mechanisms are equal in the short wavelength regime. In the long wavelength regime, the single-recollision FDI channel dominates in FDI. The nature in which molecular FDI occurs is identified and explained.
Internal atmospheric dynamics and tropical indo-Pacific climate variability

Abstract One possible explanation for tropical sea surface temperature (SST) interannual variability is that it can be accurately described by a linear autoregressive model with damped coupled feedbacks and stochastic forcing. This autoregressive model can be viewed as a “null hypothesis” for tropical SST variability. This paper advances a new coupled general circulation model (CGCM) coupling strategy, called an interactive ensemble, as a method to test this null hypothesis. The design of the interactive ensemble procedure is to reduce the stochastic variability in the air–sea fluxes applied to the ocean component while retaining the deterministic component of the coupled feedbacks. The interactive ensemble procedure uses multiple realizations of the atmospheric GCM coupled to a single realization of the ocean GCM. The ensemble mean of the atmospheric GCM fluxes are applied to the ocean model thereby significantly reducing the variability due to internal atmospheric dynamics in the air–sea fluxes. If the .
The potential role of SARS‐CoV‐2 infection in acute coronary syndrome and type 2 myocardial infarction (T2MI): Intertwining spread

Coronavirus disease 2019 (COVID‐19) is a novel pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It has been shown that SARS‐CoV‐2 infection‐induced inflammatory and oxidative stress and associated endothelial dysfunction may lead to the development of acute coronary syndrome (ACS). Therefore, this review aimed to ascertain the link between severe SARS‐CoV‐2 infection and ACS. ACS is a spectrum of acute myocardial ischemia due to a sudden decrease in coronary blood flow, ranging from unstable angina to myocardial infarction (MI). Primary or type 1 MI (T1MI) is mainly caused by coronary plaque rupture and/or erosion with subsequent occlusive thrombosis. Secondary or type 2 MI (T2MI) is due to cardiac and systemic disorders without acute coronary atherothrombotic disruption. Acute SARS‐CoV‐2 infection is linked with the development of nonobstructive coronary disorders such as coronary vasospasm, dilated cardiomyopathy, myocardial fibrosis, and myocarditis. Furthermore, SARS‐CoV‐2 infection is associated with systemic inflammation that might affect coronary atherosclerotic plaque stability through augmentation of cardiac preload and afterload. Nevertheless, major coronary vessels with atherosclerotic plaques develop minor inflammation during COVID‐19 since coronary arteries are not initially and primarily targeted by SARS‐CoV‐2 due to low expression of angiotensin‐converting enzyme 2 in coronary vessels. In conclusion, SARS‐CoV‐2 infection through hypercytokinemia, direct cardiomyocyte injury, and dysregulation of the renin‐angiotensin system may aggravate underlying ACS or cause new‐onset T2MI. As well, arrhythmias induced by anti‐COVID‐19 medications could worsen underlying ACS.
Decomposing socio-economic inequality in catastrophic out-of-pocket health expenditures in Malawi

Reducing health inequalities and inequities is one of the key goals that health systems aspire to achieve as it ensures improvement in health outcomes among all population groups. Addressing the factors contributing to inequality in catastrophic health expenditures is important to reducing inequality in the burden of health expenditures. However, there are limited studies to explain the factors contributing to inequalities in catastrophic health expenditures. The study aimed to measure and decompose socio-economic inequality in catastrophic health into its determinants. Data for the analysis come from the fourth integrated household survey. Data for 12447 households in Malawi were collected from April 2016 to April 2017 by the National Statistical Office. The secondary analysis was conducted from June 2021 to October 2021. Catastrophic health expenditure was estimated as a proportion of households whose out-of-pocket health expenditures as a ratio of non-food consumption expenditures exceeds 40% threshold level. We estimated the magnitude of socio-economic inequality using the Erreygers corrected concentration index and used decomposition analysis to assess the contribution of inequality in each determinant of catastrophic health expenditure to the overall socio-economic inequality. The magnitude of the Erreygers corrected concentration index of catastrophic health expenditure (CI = 0.004) is small and positive which indicates that inequality is concentrated among the better-off. Inequality in catastrophic health expenditure is largely due to inequalities in rural residency (127%), socio-economic status (-40%), household size (14%), presence of a child under five years old (10%) and region of the household (10%). The findings indicate that socio-economic inequality in catastrophic health expenditures is concentrated among the better-off in Malawi. The results imply that policies that aim to reduce inequalities in catastrophic health expenditures should simultaneously address urban-rural and income inequalities.
Lupus Recipe inhibits cGVHD‐induced lupus nephritis in mice and promote renal LC3‐associated autophagy

Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE). The chronic graft versus host disease (cGVHD) mouse model is a well‐established model of SLE. LC3‐associated autophagy plays a critical role in extracellular particle clearance, including pathogens and apoptotic cells. Lupus Recipe (LR) is a Chinese herbal compound that has been proven to be effective in treating SLE. In the study, we investigated the protective effects of LR or LR combined with prednisone on cGVHD mouse model and LC3‐associated autophagy in the kidney. The mice were subjected to six groups. The LR treatment group received LR at the dosage of 1.15 and 2.3 g/kg/day, respectively. The corticosteroid treatment group received prednisone at a dosage of 5 mg/kg/day. The combination treatment group received LR at a dosage of 2.3 g/kg/day, and prednisone at 2.5 mg/kg/day. LR treatment reduced proteinuria and serum triglyceride levels, as well as spleen weight. LR also alleviated pathologic damage and immunoglobulin G deposition in the kidney. LR combined with a low dose of prednisone significantly improved kidney function and decreased serum triglyceride, total cholesterol, and spleen weight. In addition, combination treatment relieved kidney injury more effectively than LR alone. Western blot revealed that LR treatment or LR combined with prednisone increased the LC3‐associated autophagy protein of Rubicon and Nox2, as well as LC3I levels in the kidney tissues. In conclusion, LR inhibited the manifestation of cGVHD‐induced LN, which may attribute to the increased levels of LC3‐associated autophagy.
Are Drinking Cognitions Associated with Marijuana and Concurrent Alcohol and Marijuana Use among Adolescents and Young Adults?

Background. Concurrent use of alcohol and marijuana (i.e., CAM use) is the most common poly-drug use pattern among adolescents and young adults and is associated with negative outcomes. Research indicates that Prototype Willingness Model (PWM) drinking cognitions are associated with alcohol use. This secondary analysis was conducted to explore cross-sectional associations between PWM drinking cognitions, alcohol, marijuana, and CAM use. Methods. Adolescents and young adults between 15-25 years (N = 124, Mage = 18.7) completed a baseline assessment as part of a larger study, including questions on alcohol and marijuana use, and PWM drinking cognitions. Results. In the social reaction pathway, descriptive norms, perceived vulnerability, and prototype favorability, but not willingness were associated with greater alcohol use, whereas in the reasoned pathway attitudes and intentions were associated with frequency of drinking whereas injunctive norms were not. Both willingness and intention to drink were related to marijuana and CAM use when controlling for alcohol use frequency. Greater willingness to drink was the only significant predictor of marijuana use, and only descriptive norms predicted CAM use. However, of the cognitions within the reasoned pathway, greater attitudes toward drinking and drinking intention were related to greater marijuana and CAM use. Results also indicated that CAM users displayed higher levels of certain risk cognitions than non-users or single substance users. Conclusion. Findings support and extend the utility of the PWM by indicating that specific alcohol cognitions are associated with alcohol, marijuana, and CAM use in adolescents and young adults.
Utilization of adolescent friendly health services and its associated factors among higher secondary students in mid-western Himalayan mountainous district of Nepal

Adolescent friendly health services (AFHS) are designed to make health services accommodate the unique needs of adolescents. AFHS are characterized by three basic characteristics (programmatic, health facilities and health service providers) that should be applied. However, limited is known about the use of AFHS in the context of Nepal. This study aimed to assess the extent of AFHS utilization and associated factors among higher secondary students in the Jumla district of Nepal. A cross-sectional quantitative study was conducted in October-November 2017. Data were collected from a random sample of 528 aged 16–19 years old using a self-administered survey in their classroom. Adjusted Odds Ratios (AOR) and a 95% confidence level were estimated to measure the strength of association between the outcome variable (utilization of AFHS) and independent variable using multivariable logistic regression. Knowledge related to AFHS, measured by a seven-item scale, was based on information about the availability of AFHS. More than two-thirds (67.05%) of adolescents had utilized AFHS at least once in the last twelve months before the survey. In multivariable logistic regression analysis, knowledge level [AOR = 14.796, 95%CI (5.326–41.099)], cost of services [AOR = 2.971, 95%CI (1.764–5.003)], satisfaction from services [AOR = 1.817, 95%CI (1.037–3.185)] and availability of waiting room [AOR = 1.897, 95%CI (1.096–3.283)] were significantly associated with the utilization of AFHS. The utilization of AFHS was less than the country’s target of universal utilization in this study. Adolescents’ knowledge level about AFHS was importantly associated with its utilization. Utilization increases with lower service costs, client satisfaction, and availability of waiting rooms in the health facility. The health planners should make efforts to create a conducive environment for the adolescent by training the AFHS providers, particularly those who work in government institutions, and strengthening the awareness creation strategies among adolescents to increase the utilization of the services.