Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Long-Term HbA1c Variability with Anxiety and Depression in Patients with Type 2 Diabetes: A Cross-Sectional Retrospective Study

Purpose To explore the relationship between long-term glycemic variability and anxiety and depression in patients with type 2 diabetes. Participants and Methods A cohort comprising 214 individuals diagnosed with type 2 diabetes participated in this study. Comprehensive demographic and laboratory information was gathered for them. The evaluation of anxiety relied on the 7-item Generalized Anxiety Disorder Scale (GAD-7), while depression was assessed utilizing the 9-item Health Questionnaire (PHQ-9). Based on the presence or absence of anxiety and depression, participants were categorized into either the mood disorder or control groups. Subsequently, univariate and stepwise multiple binary logistic regression analyses were conducted to investigate the potential correlations between factors and the presence of anxiety and depression. Results The prevalence of anxiety disorders is 23%, and depression is 32%. The prevalence of smoking, diabetic autonomic neuropathy, stroke, and osteoporosis in the mood disorder group was significantly higher than that in the control group (P < 0.05), the glycated hemoglobin A1c variability score (HVS), mean hemoglobin A1c value, total cholesterol, urinary albumin/creatinine and systemic immune-inflammatory index (SII) were significantly higher in the control group (P < 0.05). The level of high-density lipoprotein in the mood disorder group was significantly lower than the control group (P < 0.05). In stepwise multiple binary logistic regression analyses, the main factors associated with anxiety were depression (P < 0.001, OR=117.581) and gender (P < 0.001, OR=9.466), and the main factors related to depression included anxiety (P < 0.001, OR=49.424), smoking (P=0.042, OR=2.728), HVS (P=0.004, OR=8.664), and SII (P=0.014, OR=1.002). Conclusion Persistent fluctuations in blood glucose levels have been linked to anxiety and depression. Consequently, maintaining an optimal level of glycemic control and minimizing fluctuations becomes imperative in the comprehensive management of diabetes.
Digital Nomads' Willingness to Stay – a Combined Analysis of SEM and fsQCA Results

Lisbon is a multicultural city with a business center that hosts major technology companies and professionals in the field, including digital nomads. High demand for tourist accommodation and the arrival of foreigners to work in the country have led to an imbalance between the supply and affordable cost of real estate for residents of the capital. This work aims to survey and determine whether digital nomads in Lisbon intend to settle in the city or are just passing through. To identify the combination of factors that influence digital nomads’ decision-making, we conducted a quantitative study using survey data tested through structural equation modelling and configurational analysis by fsQCA. The results show that while the decision to stay in the city is heavily influenced by community attachment, we found three configurations that reveal distinct patterns of digital nomads’ intention to stay in the city. These results suggest that policymakers need to consider that digital nomads are not a homogeneous group. This study makes an important contribution to the understanding of behavioral intentions and is, to the authors’ knowledge, the first to identify different configurations based on digital nomads’ intentions to stay in a city.
Dual-Specificity Phosphatases in Regulation of Tumor-Associated Macrophage Activity

The regulation of protein kinases by dephosphorylation is a key mechanism that defines the activity of immune cells. A balanced process of the phosphorylation/dephosphorylation of key protein kinases by dual-specificity phosphatases is required for the realization of the antitumor immune response. The family of dual-specificity phosphatases is represented by several isoforms found in both resting and activated macrophages. The main substrate of dual-specificity phosphatases are three components of mitogen-activated kinase signaling cascades: the extracellular signal-regulated kinase ERK1/2, p38, and Janus kinase family. The results of the study of model tumor-associated macrophages supported the assumption of the crucial role of dual-specificity phosphatases in the formation and determination of the outcome of the immune response against tumor cells through the selective suppression of mitogen-activated kinase signaling cascades. Since mitogen-activated kinases mostly activate the production of pro-inflammatory mediators and the antitumor function of macrophages, the excess activity of dual-specificity phosphatases suppresses the ability of tumor-associated macrophages to activate the antitumor immune response. Nowadays, the fundamental research in tumor immunology is focused on the search for novel molecular targets to activate the antitumor immune response. However, to date, dual-specificity phosphatases received limited discussion as key targets of the immune system to activate the antitumor immune response. This review discusses the importance of dual-specificity phosphatases as key regulators of the tumor-associated macrophage function.
Altitudinal Control of Isotopic Composition and Application in Understanding Hydrologic Processes in the mid Merced River

1 Abstract. Mountain snowpack has been declining and more precipitation has fallen as rainfall than 30 snowfall, particularly in the US West. Isotopic composition in stream water, springs, groundwater, and precipitation was examined to understand the impact of declining snowpack on hydrologic processes in the mid Merced River catchment (1,873 km 2 ), Sierra Nevada, California, USA. Mean isotopic values in small tributaries (catchment area < 122 km 2 ), rock glacier outflows and groundwater from 2005-2008 were strongly correlated with mean catchment elevation (R 2 = 0.96 35 for  2 H, n = 16, p < 0.001), with an average isotopic lapse rate of -1.9‰/100 m for  2 H and - 0.22‰/100 m for  18 O in meteoric water. The lapse rate did not change much over seasons and was not strongly affected by isotopic fractionation. A catchment-characteristic isotopic value was thus established for each sub-catchment based on the relation between isotopic composition and the mean catchment elevation to elucidate hydrometeorologic and hydrologic processes. 40 Compared to Tenaya Creek without water falls, flow and flow duration of Yosemite Creek are much more sensitive to temperature increase due to a strong evaporation effect caused by waterfalls, suggesting possible prolonged dry-up period of Yosemite Falls in the future. Groundwater in the Yosemite Valley (~900-1,200 m) was recharged primarily from the upper snow-rain transition zone (2,000-2,500 m), suggesting its strong vulnerability to shift in snow-rain 45 ratio. The information gained from this study helps advance our understanding of hydrologic responses to climate change in snowmelt-fed river systems.
Les actinies bathyales du Chili: un exemple d'utilisation de fichiers informatiques

Cinq especes recoltees au large du Chili sont decrites. Une nouvelle presentation du cnidome est proposee; les actinies du Chili sont recensees a l'aide d'un fichier informatique regroupant les especes par secteurs geographiques. Une cle de determination des 37 genres du Chili est donnee
Molecular identification of bovine gammaherpesvirus 6 in water buffaloes (Bubalus bubalis) with histological evidence of pulmonary and intestinal lesions

Bovine gammaherpesvirus 6 (BoGHV6), formerly known as bovine lymphotropic virus, belongs to the genus Macavirus, which includes the porcine lymphotropic herpesviruses (PLHV) and members collectively referred to as malignant catarrhal fever virus (MVFV) group. This study investigated the possible participation of BoGHV6 in the development of intestinal and pulmonary diseases of buffaloes. Intestinal and pulmonary fragments were obtained from 19 buffaloes from Goiás, Central-western Brazil. Histopathology revealed interstitial pneumonia in all pulmonary fragments evaluated, while two of these had suppurative bronchopneumonia. Furthermore, all intestinal fragments demonstrated atrophic enteritis. BoGHV6 DNA was amplified from 31.6% (6/19) of the buffaloes with interstitial pneumonia and in 26.3% (5/19) with atrophic enteritis. The phylogenetic evaluation revealed that the strain of BoGHV6 amplified from these buffaloes had 100% nucleotide (nt) sequence identity with the reference strains of BoGHV6, but only 69.5 to 73.7% and 65.8 – 69.5% nt sequence identity with members of the MCFV and the PLHV, respectively. Additionally, molecular assays to detect important pathogens of ruminants did not amplify the respective nucleic acids in the tissues evaluated. These results demonstrated that BoGHV6 was amplified from tissues of buffaloes with histopathologic diagnoses of interstitial pneumonia and atrophic enteritis, suggesting the possible participation of this virus in the development of the intestinal and pulmonary lesions herein identified.
Analysing the Impact of Robot, Artificial Intelligence, and Service Automation Awareness, Technostress and Technology Anxiety on Employees’s Job Performance in The Foodservice Industry

The service industry has undergone a significant transformation due to the development and use of technology in daily operations. The use of technology in the food and beverage industry not only adds value but also allows businesses to accommodate the changing demands and tastes of their customers. However, the usage of technologies has negative consequences, such as technostress and anxiety associated with their use. With the growing impact of technology, there has been a surge in studies examining its effects on employee performance. This research aims to investigate the impact of technology, Robot, Artificial Intelligence, and Service Automation (RAISA) awareness, technostress, and technology anxiety on employee’s job performance. The present study employed a quantitative methodology. Questionnaires are distributed to all study participants as a means of collecting data. The study focuses on fast-food restaurant employees in the Jakarta area. Using the snowball sampling technique, the researchers utilize their personal connections with fast-food restaurant employees and ask them to share the questionnaire with their work colleagues. In total, there were 147 respondents who successfully completed the survey. The findings of the study found that RAISA awareness positively influences technostress, technology anxiety, and the job performance of service employees in a fast-food restaurant. In contrast, the study found that technology anxiety negatively influences the job performance of service employees in a fast-food restaurant. Likewise, it also suggests that technostress negatively influences the job performance of service employees in a fast-food restaurant. The findings of this study are expected to contribute to the literature of adoption of smart technology and its impact on employees’ job performance.
The Price of Spice: Archaeological Investigations of Colonial Era Nutmeg Plantations on the Banda Islands, Maluku Province, Indonesia

The Banda Islands were the world’s sole source of nutmeg in the 16th century. Control over the spice trade was a major goal for European powers during the Age of Expansion. Consequently, the Banda Islands were a location of early disputes and colonial experimentation. After eradicating most of the indigenous population, the Dutch East India Company established a plantation system in 1621 on the islands. The Banda Island plantation system was an early experiment in mercantile colonialism with imported enslaved workers, company-provided subsistence rations, and a VOC monopoly on the spice trade inhibiting the accumulation of capital. Peoples from a variety of European, Asian, and African backgrounds were forced to co-exist on these remote islands and create a functional society. The plantation system fundamentally altered the lifeways of all inhabitants of the Banda Islands, many of whom were non-indigenous, but there is little evidence regarding how the alterations and adaptations occurred or why. In the research outlined here, I argue that these alterations and adaptations can be investigated through the analysis of food remains, which can be accessed through both historical records and archaeological materials. Previous research on the role of food in plantation societies have focused on three main models: Energetic efficiency from optimal foraging theory, power/ resistance, and creolization. I test hypotheses created using these models based on the material culture associated with foodways that is expected to be found in colonial Banda contexts. Given a set of faunal resources, imported starches, and imported and domestic ceramics, different patterns of distribution are predicted by each model.
Receipt of Curative Resection or Palliative Care for Hepatopancreaticobiliary Tumours (RICOCHET): Protocol for a Nationwide Collaborative Observational Study

Background There are variations in the management of patients with suspected pancreatic and periampullary cancers and/or malignant biliary obstruction. These differences may be due to a number of organizational, institutional, and patient factors that could affect outcomes for those with curable or incurable disease. The Receipt of Curative Resection or Palliative Care for Hepatopancreaticobiliary Tumours (RICOCHET) study will be the first to provide a snapshot of investigative pathways across the United Kingdom to reflect the real-world practice in these patients. The RICOCHET study is contemporary to new national and international clinical guidance and can potentially inform future local and national strategic planning to optimize care for patients with suspected hepatopancreaticobiliary (HPB) malignancies. Objective The aim of this study is to define national variation in the investigative and management pathways of patients with suspected HPB malignancies and to determine the effect of these variations on patient outcomes. Methods The RICOCHET study is a nationwide, multicenter, prospective study. It is led by trainees through collaboration between surgical and medical specialties. Patients with suspected pancreatic cancer, other periampullary cancer, or extrahepatic cholangiocarcinoma presenting to hospitals in the United Kingdom will be identified over 90 days. Each case will be followed up for 90 days to collect data on the mode of presentation, investigations, interventions, use of local and specialist multidisciplinary team meetings, and transfer of care between hub and spoke sites. Furthermore, the study will define dates and intervals between key points in the patient pathway. Results The RICOCHET study results and analyses will be subject to peer review by presenting them at international cross-specialty conferences and by submitting them for publication in open-access journals. Moreover, our findings will be presented to patient groups and sponsoring charities (eg, Pancreatic Cancer UK), who in turn will disseminate key findings to the primary beneficiaries of the results: the patients. The RICOCHET study was funded in September 2017. Data collection started in April 2018 and the planned end date for data upload is spring 2019. Data analysis will take place in the summer of 2019 and the first results are expected to be published in late 2019 or early 2020. Conclusions The RICOCHET study is a multidisciplinary, prospective, observational study that aims to highlight variability in practice and to determine whether these affect the outcomes of patients with HPB malignancies. This is a trainee-led initiative that utilizes a novel design to achieve full coverage of the differences in diagnostic and management pathways. The RICOCHET study may provide evidence to develop a more standardized approach to managing patients with suspected HPB malignancy. International Registered Report Identifier (IRRID) DERR1-10.2196/13566
Combined Effects of Ziziphus jujuba, Dimocarpus longan, and Lactuca sativa on Sleep-Related Behaviors through GABAergic Signaling

We aimed to analyze the increase in the sleep-promoting effects based on the mixed ratio of botanical extracts, Ziziphus jujuba seeds, Dimocarpus longan fruits, and Lactuca sativa leaves, using animal models. Behavioral analyses, including an analysis of the total sleep time of Drosophila melanogaster, were conducted to select the optimal mixed ratio of the three botanical extracts. The effects were verified in a caffeine-induced sleepless model, specific neurotransmitter receptor antagonists, and ICR mice. In D. melanogaster exposed to 2.0% of each extract, group behavior was significantly reduced, and the mixed extracts of Z. jujuba, D. longan, and L. sativa (4:1:1 and 1:4:1) significantly increased the total sleep time with individual fruit flies. In the caffeine-induced insomnia model, mixed extracts (4:1:1 and 1:4:1) led to the highest increase in total sleep time. An analysis of locomotor ability revealed a significant reduction in the mobility percentage in the mixed extract groups (0:0:1, 1:0:1, 1:1:1, 4:1:1, and 1:4:1). The administration of Z. jujuba extract and mixed extracts (4:1:1) significantly increased the expression of GABAA-R, whereas the administration of the mixed extracts (4:1:1) and (1:4:1) significantly increased the expression of GABAB-R1 and GABAB-R2, respectively. D. longan extract and the mixed ratio (1:4:1) reduced the subjective nighttime movement and increased the total sleep time in the presence of flumazenil. An analysis of ICR mice indicated that the administration of mixed extracts (4:1:1) significantly increased sleep duration in a dose-dependent manner. These results indicated that the mixed ratio of Z. jujuba, D. longan, and L. sativa extracts, particularly the mixed ratio of 4:1:1, may have sleep-enhancing effects in fruit flies and mice. The study also identified changes in gene expression related to GABA receptors, indicating the potential mechanism for the observed sleep-promoting effects.
Geomorphology of marine and transitional terraces and raised shorelines between Punta Paulo and Porvenir, Tierra del Fuego, Straits of Magellan – Chile

ABSTRACT This paper presents a coastal geomorphology map of some of the Chilean region of the Straits of Magellan, and is based on a combined geomorphological and sedimentological approach applicable to a larger section of the coast. The mapped area is located in Tierra del Fuego between the Segunda Angostura of the Straits of Magellan and Bahía Inútil. A detailed geomorphological map was compiled at a scale of 1:50,000, describing a sequence of 4 marine and transitional (glacio-lacustrine to marine) terrace orders and raised marine shorelines found between 0 and + 20 m. These features are mainly linked to glacio-eustasy and secondarily to Holocene neo-tectonics. This research derives from the interpretation of aerial photographs and remote sensing imagery along with geomorphological-stratigraphic field surveys and geochemical data. The Main Map illustrates an area with dominant palaeo-glacial and glacio-lacustrine morphology with extensive lacustrine deposits and well-developed lake systems characterising the Porvenir region.
Associations Between Lipoprotein(a) Levels and Cardiovascular Outcomes in Black and White Subjects: The Atherosclerosis Risk in Communities (ARIC) Study

Background— On the basis of studies with limited statistical power, lipoprotein(a) [Lp(a)] is not considered a risk factor for cardiovascular disease (CVD) in blacks. We evaluated associations between Lp(a) and incident CVD events in blacks and whites in the Atherosclerosis Risk in Communities (ARIC) study. Methods and Results— Plasma Lp(a) was measured in blacks (n=3467) and whites (n=9851). Hazards ratios (HRs) for incident CVD events (coronary heart disease and ischemic strokes) were calculated. Lp(a) levels were higher with wider interindividual variation in blacks (median [interquartile range], 12.8 [7.1–21.7] mg/dL) than whites (4.3 [1.7–9.5] mg/dL; P<0.0001). At 20 years of follow-up, 676 CVD events occurred in blacks, and 1821 events occurred in whites. Adjusted HRs (95% confidence interval) per race-specific 1-SD–greater log-transformed Lp(a) were 1.13 (1.04–1.23) for incident CVD, 1.11 (1.00–1.22) for incident coronary heart disease, and 1.21 (1.06–1.39) for ischemic strokes in blacks. For whites, the respective HRs (95% confidence intervals) were 1.09 (1.04–1.15), 1.10 (1.05–1.16), and 1.07 (0.97–1.19). Quintile analyses showed that risk for incident CVD was graded but statistically significant only for the highest compared with the lowest quintile (HR [95% confidence interval], 1.35 [1.06–1.74] for blacks and 1.27 [1.10–1.47] for whites). Similar results were obtained with the use of Lp(a) cutoffs of ⩽10 mg/dL, >10 to ⩽20 mg/dL, >20 to ⩽30 mg/dL, and >30 mg/dL. Conclusions— Lp(a) levels were positively associated with CVD events. Associations were at least as strong, with a larger range of Lp(a) concentrations, in blacks compared with whites.
Deciphering the intricate hierarchical gene regulatory network: unraveling multi-level regulation and modifications driving secondary cell wall formation

Abstract Wood quality is predominantly determined by the amount and the composition of secondary cell walls (SCWs). Consequently, unraveling the molecular regulatory mechanisms governing SCW formation is of paramount importance for genetic engineering aimed at enhancing wood properties. Although SCW formation is known to be governed by a hierarchical gene regulatory network (HGRN), our understanding of how a HGRN operates and regulates the formation of heterogeneous SCWs for plant development and adaption to ever-changing environment remains limited. In this review, we examined the HGRNs governing SCW formation and highlighted the significant key differences between herbaceous Arabidopsis and woody plant poplar. We clarified many confusions in existing literatures regarding the HGRNs and their orthologous gene names and functions. Additionally, we revealed many network motifs including feed-forward loops, feed-back loops, and negative and positive autoregulation in the HGRNs. We also conducted a thorough review of post-transcriptional and post-translational aspects, protein–protein interactions, and epigenetic modifications of the HGRNs. Furthermore, we summarized how the HGRNs respond to environmental factors and cues, influencing SCW biosynthesis through regulatory cascades, including many regulatory chains, wiring regulations, and network motifs. Finally, we highlighted the future research directions for gaining a further understanding of molecular regulatory mechanisms underlying SCW formation.
Individual characteristics on multicultural team performance: does the role played by leaders and team members matter?

The main purpose of this study was to analyze the impact of individual characteristics of cultural sensitivity, adaptability, cohesion, and cultural diversity on the multicultural team performance. Also, we analyzed the moderating effect of being a team member or a team leader on the relationships mentioned above. To test out hipotheses, data were collected from 415 members of multicultural teams specifically, from 304 team members and 111 leaders. The findings provided evidence to support a positive relationship between cultural sensitivity, adaptability, cohesion, and team performance. Cultural diversity did not show a significant impact on team performance. The study also showed that the leaders and members had different perceptions about the factors that influence team performance. For instance, team members consider that cohesion influences team performance, while leaders consider adaptability as the key factor to achieve performance. Main implications from findings are discussed.