Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Hypertension, Diabetes, and Hyperlipidemia on Medication Intake and Adherence: Analysis from Korean Health Panel Survey 2014–2017

Background: Hypertension, diabetes, and hyperlipidemia are common chronic diseases in South Korea, and medication is a key factor in managing these diseases and preventing disease advancement to multimorbidity. This study aimed to evaluate the effect of chronic disease on medication intake and adherence among Koreans. Methods: This study was conducted utilizing data collected from 5,529 individuals that participated in the Korea Health Panel Survey (KHPS) in 2014–2017. The dependent variables were medication intake and adherence, and independent variables included socioeconomic status and the type of chronic disease. The differences in the medication intake and medication adherence by sociodemographic variables and the type of chronic disease were analyzed by chi-square test. The effect of hypertension, diabetes, and hyperlipidemia on medication intake and adherence was analyzed via multiple logistic regression using SAS statistical software. Results: The rate of medication intake and adherence were significantly different among patients with hypertension, diabetes, and hyperlipidemia, especially lower in patients with hyperlipidemia compared to those with hypertension and diabetes. In multiple logistic regression analysis, the probability of medication intake increased in female gender, older age, medical aid, medication adherence was higher in married, lower educational level and lower household income. Compared to hyperlipidemia, patients with hypertension and diabetes had more likely to take medication as prescribed. Conclusion: The importance of considering the type of chronic disease in developing and implementing public health programs aiming for improved medication adherence. Targeting better medication intake and adherence for each chronic disease could be a valuable policy strategy to effectively manage chronic diseases as well as prevent their complications.
Threat through the Screen? Association between Proximity and/or Watching Media Coverage of a Terrorist Attack and Health

Introduction: After terrorist attacks, media coverage of the attacks is extensive. There are some indications that there is an association between watching the media coverage and certain health reactions, both mental and somatic. Most studies occur in the United States and often months after the initial attack. In the current study, we investigated the terrorist attacks in Belgium on 22 March 2016. Methods: An online cross-sectional survey was conducted one week after the attacks among the general population of Belgium. We measured hours of media watching of the terrorist attacks (hereafter media watching), adjusted scales of the Patient Health Questionaire-4 (PHQ-4) to measure mental symptoms and the Patient Health Questionaire-15 (PHQ-15) to measure somatic symptoms, proximity to Brussels (home, work and overall proximity) and background factors such as gender, age and level of education. Respondents were included if they answered the survey between 29 March 2016 and 5 April 2016. Results: A total of 2972 respondents were included. Overall, media watching was significantly associated with both mental symptoms (p < 0.001) and somatic symptoms (p < 0.001), while controlling for age, gender, level of education and proximity. Watching more than three hours of media was associated with more mental and somatic symptoms (p < 0.001). Compared to proximity, media watching was, in general, a better association. For geographical factors, watching more than three hours of media indicated equally high scores for mental symptoms and somatic symptoms as work proximity (p = 0.015) and overall proximity to the attacks (p = 0.024). Conclusion: Media-watching is associated with acute health reactions after terrorist attacks. However, the direction of the relationship is unclear, as it might also be that people with health issues seek out more media.
Methylprednisolone pulse therapy for critically ill patients with COVID-19: a cohort study

Background The guidelines recommend the use of dexamethasone 6 mg or an equivalent dose in patients with coronavirus disease 2019 (COVID-19) who require supplemental oxygen. Given that the severity of COVID-19 varies, we investigated the effect of a pulse dose of corticosteroids on the clinical course of critically ill patients with COVID-19. Methods This single-center, retrospective cohort study was conducted between September and December 2021, which was when the Delta variant of the COVID-19 virus was predominant. We evaluated the mortality and oxygenation of severe to critical COVID-19 cases between groups that received dexamethasone 6 mg for 10 days (control group) and methylprednisolone 250 mg/day for 3 days (pulse group). Results Among 44 patients, 14 and 30 patients were treated with control steroids and pulse steroids, respectively. There was no difference in disease severity, time from COVID-19 diagnosis to steroid administration, or use of remdesivir or antibacterial agents between the two groups. The pulse steroid group showed a significant improvement in oxygenation before and after steroid treatment (P<0.001) compared with the control steroid group (P=0.196). There was no difference in in-hospital mortality (P=0.186); however, the pulse steroid group had a lower mortality rate (23.3%) than the control steroid group (42.9%). There was a significant difference in the length of hospital stay between both two groups (P=0.039). Conclusions Pulse steroids showed no mortality benefit but were associated with oxygenation improvement and shorter hospital stay than control steroids. Hyperglycemia should be carefully monitored with pulse steroids.
Prevalence of Potential Pathogenic and Antimicrobial Resistant Escherichia coli in Danish Broilers

Avian pathogenic Escherichia coli (APEC) are important bacteria in broiler production in terms of economy, welfare, and use of antibiotics. During a previous outbreak of APEC in the Nordic countries, it was suggested that the pathogenic clones of E. coli causing the outbreak originated from grandparent stock and were transmitted to the offspring, causing increased first week mortality. This study investigated whether the pathogenic potential of E. coli at the parent and broiler level differs in relation to pathogenic potential described by the level of virulence-associated genes and pattern of antimicrobial resistance. The hypothesis was that, due to higher biosecurity at the parent level, the E. coli population will show a lower level of antimicrobial resistance and carry fewer virulence-associated genes, as a result of fewer E. coli infections observed. From four parent flocks and eight broiler flocks, 715 E. coli were isolated from cloacal swabs of newly hatched chickens (Ross 308). The isolated E. coli were characterized by eight virulence-associated genes and phenotypic resistance against six antimicrobials. It was found that the prevalence of virulence-associated genes and phenotypic antimicrobial resistance varied significantly between flocks, and the virulence-associated genes papC and irp2 and resistance against ampicillin were significantly more prevalent in breeder flocks compared to broiler flocks.
Therapeutic Cell Repopulation of the Liver: From Fetal Rat Cells to Synthetic Human Tissues

Progenitor cells isolated from the fetal liver can provide a unique cell source to generate new healthy tissue mass. Almost 20 years ago, it was demonstrated that rat fetal liver cells repopulate the normal host liver environment via a mechanism akin to cell competition. Activin A, which is produced by hepatocytes, was identified as an important player during cell competition. Because of reduced activin receptor expression, highly proliferative fetal liver stem/progenitor cells are resistant to activin A and therefore exhibit a growth advantage compared to hepatocytes. As a result, transplanted fetal liver cells are capable of repopulating normal livers. Important for cell-based therapies, hepatic stem/progenitor cells containing repopulation potential can be separated from fetal hematopoietic cells using the cell surface marker δ-like 1 (Dlk-1). In livers with advanced fibrosis, fetal epithelial stem/progenitor cells differentiate into functional hepatic cells and out-compete injured endogenous hepatocytes, which cause anti-fibrotic effects. Although fetal liver cells efficiently repopulate the liver, they will likely not be used for human cell transplantation. Thus, utilizing the underlying mechanism of repopulation and developed methods to produce similar growth-advantaged cells in vitro, e.g., human induced pluripotent stem cells (iPSCs), this approach has great potential for developing novel cell-based therapies in patients with liver disease. The present review gives a brief overview of the classic cell transplantation models and various cell sources studied as donor cell candidates. The advantages of fetal liver-derived stem/progenitor cells are discussed, as well as the mechanism of liver repopulation. Moreover, this article reviews the potential of in vitro developed synthetic human fetal livers from iPSCs and their therapeutic benefits.
Multi-Armed Bandit for Link Configuration in Millimeter-Wave Networks: An Approach for Solving Sequential Decision-Making Problems

Establishing and maintaining millimeter-wave (mm-wave) links are challenging due to the changing environment and the high sensibility of mm-wave signals to user mobility and channel conditions. mm-Wave link configuration problems often involve a search for optimal system parameter(s) under environmental uncertainties from a finite set of alternatives that are supported by the system hardware and protocol. For example, beam sweeping aims at identifying the optimal beam(s) for data transmission from a discrete codebook. Selecting parameters such as the beam sweeping period and the beamwidth is crucial to achieving high overall system throughput. In this article, we motivate the use of the multi-armed bandit (MAB) framework to intelligently search out the optimal configuration when establishing the mm-wave links. MAB is a reinforcement learning framework that guides a decision maker to sequentially select one action from a set of actions. As an example, we show that within the MAB framework, the optimal beam sweeping period, beamwidth, and beam directions could be dynamically learned with sample-computational-efficient bandit algorithms. We conclude by highlighting some future research directions on enhancing mm-wave link configuration design with MAB.
Yield-density equations and their application for agronomic research: a review.

Plant population density (density) trials are time consuming, repetitive and cost intensive. The literatures indicate that density trials are more effectively and efficiently described when meaningful yield-density equations such as reciprocal linear and/or parabolic equations are applied to quantify data. Several of these types of equations and their derivatives such as competitive indices have been proposed. It is generally agreed that where response to density deviated from linearity, equations based on linear reciprocal of yield per plant and density can satisfactorily describe an asymptotic response. In certain cases when the harvest index is substantially affected by density and/or due to unfavourable growth conditions, equations that assumed parabolic responses may be more valid. The review by Willey and Heath (1969) on the quantitative response of yield to density appears to have remained a useful resource up to date. However, more recently, several investigations based on reciprocal quantitative relationships between yields and density and how this may be influenced by other agronomic practices were carried out. Yet, most of these substantial knowledge and progress on yield-density investigations appear to be scattered in published or unpublished works as no attempt has been made to collate them together. This paper reviews more recent progress on yield-density equations research and their application, and highlights needs for the applications of some of these equations for agronomic research with more emphasis given to intercropping.
Formation of fingers around the edges of a drop hitting a metal plate with high velocity

Water droplets (0.55 or 1.3 mm diameter) were photographed as they impinged on a stainless steel surface. The droplet impact velocity (10–50 m s−1) and the average roughness (0.03 or 0.23 μm) of the test surfaces were varied. The stainless steel substrate was mounted on the end of a rotating arm, giving linear velocities of up to 50 m s−1. Different stages of droplet impact were photographed by synchronizing the ejection of a single droplet with the position of the rotating arm and triggering of a camera. Finger-shape perturbations were observed around the edges of spreading droplets. The maximum diameter to which a droplet spread and the number of fingers formed around it were measured. The size and number of fingers increased with impact velocity and droplet diameter. At sufficiently high velocities, the tips of these fingers detached, producing satellite droplets. By increasing surface roughness, both the number of fingers and the maximum extent of spreading were decreased. At high impact velocities the spreading liquid film became so thin that it ruptured in several places. A mathematical model, based on linear Rayleigh–Taylor instability theory, was used to predict the wavelength of the fastest growing perturbation around a spreading droplet. The corresponding wavenumber agreed reasonably well with the number of fingers around the droplet.
Neuroprotective Effect of Melatonin on Sleep Disorders Associated with Parkinson’s Disease

Parkinson’s disease (PD) is a complex, multisystem disorder with both neurologic and systemic manifestations, which is usually associated with non-motor symptoms, including sleep disorders. Such associated sleep disorders are commonly observed as REM sleep behavior disorder, insomnia, sleep-related breathing disorders, excessive daytime sleepiness, restless legs syndrome and periodic limb movements. Melatonin has a wide range of regulatory effects, such as synchronizing circadian rhythm, and is expected to be a potential new circadian treatment of sleep disorders in PD patients. In fact, ongoing clinical trials with melatonin in PD highlight melatonin’s therapeutic effects in this disease. Mechanistically, melatonin plays its antioxidant, anti-inflammatory, anti-excitotoxity, anti-synaptic dysfunction and anti-apoptotic activities. In addition, melatonin attenuates the effects of genetic variation in the clock genes of Baml1 and Per1 to restore the circadian rhythm. Together, melatonin exerts various therapeutic effects in PD but their specific mechanisms require further investigations.
The Influence of the Galactic Bar on the Dynamics of Globular Clusters

We make use of recent estimates for the parameters of the Milky Way’s halo globular clusters and study the influence of the galactic bar on the dynamics of these clusters by computing their orbits. We use both an axisymmetric and non-axisymmetric galactic potentials, which include the rotating elongated bar/bulge structure. We account for observational errors both in the positions and in the velocities of the globular clusters and explore the influence of the bar on clusters’ evolution. This is contained in the angular momentum–total energy plane, (Lz,E), which is widely exploited as an indicator of the groups of globular clusters that originated from the same accretion event. Particular attention is devoted to the Gaia-Sausage/Enceladus and Pontus structures identified recently as two independent accretion events. Our study shows that it is not possible to identify GSE and Pontus as different merger events.
TINJAUAN KRITIS TERHADAP KEBIJAKAN HILIRISASI KAKAO DI INDONESIA

The Indonesian government has implemented a policy of exporting cocoa beans through the Minister of Finance Regulation No. 67/PMK.011/2010 to stimulate the growth of the processing industry. This article examines the policy's effectiveness and impact on the cocoa industry. This study uses a literature review method from various secondary data sources. The results revealed that the implementation of the export duty policy had achieved its goal of developing the national cocoa industry and increasing exports. The policy impacts are the decline in cocoa bean exports, the growing cocoa processing industry, and the increase in processed cocoa exports. This policy raises side effects such as insufficient volume and quality of cocoa beans. The disconnect between upstream and downstream subsystems in cocoa agribusiness hinders the development of the national cocoa commodity. The government needs to carry out a few things to thrive cocoa industry. The government should implement a synergic and comprehensive policy alignment on the Indonesia cocoa agribusiness system, review the export duty rate policy to a flat 15%, improve productivity and increase cocoa beans production to compensate for the increased capacity of the cocoa processing industry. The government must also revitalize the national cocoa development movement by increasing cocoa competitiveness.
Mapping high-resolution surface shortwave radiation over East Asia with the new generation geostationary meteorological satellite Himawari-8

ABSTRACT Surface shortwave radiation (SSR) plays an important role in global energy systems. The new generation of geostationary meteorological satellite Himawari-8, with higher spatiotemporal and spectral resolution, offers a new opportunity to retrieve SSR with higher accuracy. In this study, an improved algorithm was applied to estimate instantaneous, hourly, and daily mean SSR using cloud products from the Advanced Himawari Imager (AHI) onboard the Himawari-8 satellite. The validation against Baseline Surface Radiation Network (BSRN) stations showed a root mean square error (RMSE) of 95.8 W m−2 for instantaneous SSR, 82.4 W m−2 for hourly SSR, and 22.8 W m−2 for daily SSR and mean bias error (MBE) of −15.8 W m−2, −14.1 W m−2, and −6.6 W m−2. The validation against China Meteorological Administration (CMA) stations showed a RMSE of 99.5 W m−2 and MBE of −8.2 W m−2 for hourly SSR and RMSE of 27.7 W m−2 and MBE of −3.9 W m−2 for daily SSR, which are generally better than the Himawari-8 SSR product. Overall, the improved algorithm performed well on the new-generation geostationary satellite, with high accuracy and efficiency, and would contribute to surface process research and photovoltaic engineering applications.
Measuring Response of Stock Market to Central Bank Independence Shock

This paper examines the responses of stock traded and economic activity in relation to central bank independence shocks. The analysis is based on a panel Vector Autoregressive estimation covering 25 developing countries for a quarterly period between 1990 Q1 and 2021 Q4. Panel VAR estimation is known to be potentially biased in a dynamic panel data model if the coefficient on the endogenous variables differs across countries. To test the pooling assumption of the model, this paper applies the Chow and Roy-Zellner tests. The results establish that the models contain the heterogeneity among samples; thus, mean-group estimation for panel VAR is performed as a solution for heterogeneity problem. The results show that there is a delayed effect of CBI to increase stock traded. This demonstrates that CBI takes around six quarters to strengthen the financial market. By dividing the sample into two groups, we find that CBI has a different effect on stock traded for countries that have high and low stock traded.
Experiment on the turbulent boundary layer over convex walls and its recovery to flat-wall conditions

The experiments were performed at a ratio of the thickness at which velocity is 99% of the potential flow velocity to the surface radius of curvature of about 0.09 on a convex wall, where the curvature effects are strong. The data show that a flat-wall boundary layer is strongly affected by curvature only a few boundary layer thicknesses downstream of the start of convex curvature. On the other hand, in flow over a flat surface downstream of convex curvature, the effects of curvature persist downstream for ten or more boundary layer thicknesses. It appears that the boundary layer over a convex wall may have a multilayer character which is slow to return to normal, flat-plate equilibrium.
The Level of Burden among Caregivers of Patients with Alzheimer’s Disease in Saudi Arabia

Background: Caregiver burden is a serious global issue associated with the growing number of older adult patients with Alzheimer’s disease (AD). AD patients become more dependent on their caregivers and require assistance with basic daily life activities. This study aims to measure the caregiver burden of informal caregivers of AD patients and to determine their characteristics. In addition, it intends to understand caregiver coping techniques and assess their medication knowledge. Methods: This was a cross-sectional study including 148 informal caregivers mainly recruited by the Saudi Alzheimer’s Disease Association (SADA). A four-part study questionnaire was used for data collection in the Arabic Language and included the following: socio-demographic characteristics of AD patients and their caregivers, the 12-item version of the Zarit Burden Interview (ZBI), and adapted questions on coping techniques and medication knowledge. Results: A total of 148 caregivers (62% were female) participated in this study, and 79.06% were between 30 and 60 years old. The ZBI average score was 27, indicating a moderate to high burden. Caregivers reported their need for services to improve their quality of life. The medication knowledge was insufficient in most aspects except that more than half were aware of medications’ side effects. Conclusion: Our study revealed that the average burden among informal caregivers of AD patients was moderate–high.
Permutation-Based Short-Packet Transmissions Improve Secure URLLCs in the Internet of Things

As a promising candidate for ultrareliable and low-latency communications, the recent permutation-based transmission concept substantially improves the resource utilization efficiency in the Internet of Things (IoT). In this context, the Age of Information (AoI) experienced in permutation-based short-packet transmissions is characterized in a wiretap channel, where eavesdroppers are wiretapping the status updates delivered over the legitimate link. The AoI of the legitimate link and the secrecy margin of the wiretap channel are formulated in closed forms within the regime of finite-blocklength information theory to quantify the data freshness and security of status updates in the IoT. The optimal packet structure to be delivered over the network interface is found by solving the optimization problems of minimizing the legitimate link’s AoI and maximizing the secrecy margin. Illustrative numerical results are provided for our permutation-based transmission to quantify its performance gains over the conventional encapsulation, specifically in short-packet communications.