Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of colonic adenomas recurrence after adenoma removes

Objective: Some neoplasms are missed in colonoscopy procedures make the colonic adenoma surveillance intervals difficult to put into practice. Our research tried to avoid the influence of missed neoplasms, analyzed the adenoma recurrence and provided surveillance suggestion for patients after polypectomy or other endoscopic therapy. Methods: A total of 303 patients with colonic adenoma and lesions remove between 2005 and 2009 were respectively analyzed, all patients were suggested colonoscopy within 6 months after initial colonoscopy and removed missed adenomas. Every patient underwent surveillance colonoscopies every 1-2 years to detect the adenomas recurrence. Results: The median recurrence time was 23 months, male patients, patients older than 60 years, patients with extracolonic tumor history; with alcohol history and patients with >= 3 adenomas has high risk of adenoma recurrence. Conclusions: The first surveillance colonscopy are suggested 24 months after initial colonscopy, if patients are male patients, older than 60 years, with extracolonic tumor history or drinking history in the mean time, shorter surveillance interval are suggested.
Anatomy of emissions trading systems

An anatomy identifies four main components of actual or proposed Emissions Trading Systems (ETS): (1) Pursued policy goals with the ETS instrument; (2) Public authority allocations of permits to the regulated participants; (3) Carbon emissions price levels; and (4) Participants’ abatement expenses dependent on the ready availability of affordable abatement techniques or of low-carbon innovation opportunities. These components cover a range of options. A different assemblage of options delivers different ETS exemplars. Two main exemplars are identified. The actual EU ETS is highly successful in meeting the goal of low financial burdens on EU industry, thereby precluding carbon leakage. The other exemplar opts for high carbon emissions prices in the EU to induce industrial innovations towards a low-carbon economy. Incumbent industrial interests oppose this exemplar. Contrary to current policy discourse and to wishful proposals, both ETS exemplars cannot co-exist. ETS anatomy offers insight and structure for thorough analysis and evaluation of existing ETS, resulting in context–specific and appropriate designs of the carbon trading systems.
What is CEO Overconfidence? Evidence from Executive Assessments

We use detailed assessments of CEO personalities to explore the option-based measure of CEO overconfidence, Longholder, introduced by Malmendier and Tate (2005a) and widely used in the behavioral corporate finance and economics literatures. Longholder is significantly related to several specific characteristics and is negatively related to general ability. These relations also hold for overconfidence measures derived from CEOs’ earnings guidance. Investment-cash flow sensitivities are larger for both Longholder and less able CEOs. Overall, Longholder CEOs have many of the same characteristics traditionally associated with overconfident individuals, including lower general ability, supporting the interpretation of this measure as reflecting overconfidence.
Prevalence of work related neck pain in computer operators

Objective: To determine the prevalence of work related neck pain in computer operators. Methodology: There were 309 computer operators taken for this research. The prevalence of neck pain was assessed with the help of a questionnaire. The results were analyzed through SPSS-20 software. Results: Neck pain was more common in female computer operators. It was more common in middle class computer operators as compared to others. 67.3% of computers operators complained of localized neck and 32.7% complained of radiating neck pain. Neck pain occurred in computer operators due to wrong posture. It reduced the performance of computer operators. Neck pain was more common in those computer operators that used computer randomly 1-3 hours. Conclusion: Female computer operators were more victims of neck pain as compared to male computer operators. Key Words: Neck pain, computer operators, ergonomics.
Accessibility Issues in Android Apps: State of Affairs, Sentiments, and Ways Forward

Mobile apps are an integral component of our daily life. Ability to use mobile apps is important for everyone, but arguably even more so for approximately 15% of the world population with disabilities. This paper presents the results of a large-scale empirical study aimed at understanding accessibility of Android apps from three complementary perspectives. First, we analyze the prevalence of accessibility issues in over 1, 000 Android apps. We find that almost all apps are riddled with accessibility issues, hindering their use by disabled people. We then investigate the developer sentiments through a survey aimed at understanding the root causes of so many accessibility issues. We find that in large part developers are unaware of accessibility design principles and analysis tools, and the organizations in which they are employed do not place a premium on accessibility. We finally investigate user ratings and comments on app stores. We find that due to the disproportionately small number of users with disabilities, user ratings and app popularity are not indicative of the extent of accessibility issues in apps. We conclude the paper with several observations that form the foundation for future research and development.
New treatment approaches for relapsing/refractory Hodgkin’s lymphoma: An overview of the Brazilian scenario

Hodgkin’s lymphoma (HL) is a B-cell malignancy with a classical bimodal distribution with incidence peaking in the third and sixth decades of life. The purpose of this review is to describe the current unmet medical need for relapsing/refractory HL and the main data of emerging treatments, including brentuximab vedotin, the immune checkpoint inhibitors nivolumab and pembrolizumab, as well as other compounds in development. Available guidelines for relapsing/refractory HL are discussed.
Enabling Real-Life Deployment of Piggyback-VLC via Light Emission Composition

Whereas the increasing popularity of both commercial light-emitting diode (LED) lighting and mobile devices certainly creates opportunity for real-life deployment of visible light communication (VLC) systems, reaching the high throughput promised by lab experiments still faces major obstacles. In particular, lacking the sophisticated hardware and software support under experimental conditions, real-life systems are challenged in many aspects, especially low signal-to-noise ratio, low operation frequency, uncontrollable LED nonlinearity, and illumination requirements. Nonetheless, deployments tapping commercial infrastructure are critical to gain market penetration for VLC-enabled wireless applications, so boosting the performance of these real-life systems becomes imperative. In this article, we consider the multiple LED chips and/or light sources nature of indoor commercial lighting infrastructure, and propose a spatial modulation that composes the cooperative light emissions (transmissions) from multiple LEDs. In addition to gaining a higher spectral efficiency, this scheme utilizes the multiple-LED nature of commercial lighting to overcome LED nonlinearity with a novel yet simplified hardware construction. We present two typical designs adopting this special modulation under different infrastructural constraints, and provide an introduction on its potential contribution to the standardization of VLC. Finally, we discuss potential extensions to further improve performance.
Regulators of Ubiquitin Dependent Protein Degradation in the Filamentous Fungus Aspergillus nidulans : Insights into CsnB, DenA and CandA Function

Ubiquitin dependent protein degradation is a central mechanism regulating multiple functions in cells. Ubiquitination of target proteins requires an enzyme cascade including ubiquitin ligases (E3s). One group of E3s contains cullins as the core component. Activity of these cullin containing E3s is modulated by the covalent modification of cullin with the ubiquitin like protein Nedd8. In this work three regulators of cullin containing E3s were studied in the fungus Aspergillus nidulans. (i) The COP9 signalosome (CSN) possess an enzyme activity that deneddylates cullins. Csn2/CsnB, the second subunit of the CSN, mediates the binding of the complex to ubiquitin ligases in mammals via binding to cullin. This study shows that the fungal CsnB interacts with CulD, suggesting a conserved function of the protein. Deletion of csnB leads, like deletion of the genes for other subunits of the CSN such as csnA, csnD or csnE, to a typical csn-deletion phenotype including red pigment formation and a block in sexual development. These results support the notion that all subunits of the complex are crucial for the deneddylase function. (ii) The putative mammalian Den1 homolog of the fungus (DenA) was proven to exhibit deneddylase activity in vivo. For the first time, this deneddylase was successfully deleted in an organism. Loss of denA in A. nidulans leads to a reduction of asexual development and an increased production of sexual structures. (iii) Mammalian Cand1 binds to cullins, thereby influencing the assembly of cullin containing E3s. In Aspergilli, the corresponding gene is split into two independent open reading frames encoding the N- and C-terminal part (candA-N, candA-C) of the mammalian homolog. Deletion of the single or both candA genes leads to mutants with identical phenotypes. They produce only few asexual spores, are blocked in early sexual development and appear dark red when grown under development inducing conditions. All defects of the candA deletion mutants can be complemented by a candA-N:: C fusion construct indicating that the split is not crucial for protein functions. Only CandA-C, but not CandA-N, binds to cullins. Since both CandA proteins interact with each other, binding of CandA-N to cullin is presumably mediated by CandA-C. CandA-C is nuclear enriched and expressed in vegetative cultures but degraded at an early stage of sexual development indicating a role during onset of development. The culture filtrate of both candA and csnE deletion mutants contains orsellinic acid related substances suggesting a connection of CandA and CsnE to the regulation of secondary metabolism. This study shows that the three regulators described are crucial for fungal development, indicating that fungi are useful models to analyze the interplay between cullin containing E3 activity and differentiation.
Enhancing Patient’s Safety: Understanding Theatre Team’s Attitude as a Barrier towards Use of Surgical Safety Checklist in Kenya

Surgical safety is a global initiative to reduce the mortality and morbidity rate of patients undergoing surgical procedures. Over 234 million surgeries are performed annually all over the world with a mortality of over 1 million and over 7 million getting complications from the procedures [1]. As a result of this, surgical Safety Checklist (SSC) was developed to reduce chances of surgical complications [2]. While the use of the checklist has shown significant reduction of both mortality and morbidity rates, available data indicate that despite its implementation in many hospitals, its use is still a mirage [3]. This study sought to determine the influence of theatre team’s attitude on use of surgical safety checklist. The study adopted a cross sectional survey utilizing both qualitative and quantitative methods of data collection. Stratified random sampling technique was used to sample 277 respondents from the study area. Data were collected using a pre-tested questionnaire. The quantitative data was analyzed using SPSS. Version 22 while qualitative data was analyzed using ATLASti. The study established that about 66% of the surgical team implemented WHO’s SSC fully. However, a significant 34% did not implement it fully. The study found that theatre team’s attitude influenced use SSC. The study concludes that utilization of the WHO SSC is affected by Attitude (p < 0.05). We recommend frequent trainings on implementation of SSC by the Ministry of Health (MoH) and the concerned hospital administrative wings as well as relevant policies to ensure compliance. It is also recommended that other studies in other health facilities across the country be done so as to compare findings on the factors affecting implementation of WHO’s SSC.
Proteostasis Regulators and Pharmacologic Chaperones Synergize to Correct Protein Misfolding Diseases

Loss-of-function diseases are often caused by a mutation in a protein traversing the secretory pathway that compromises the normal balance between protein folding, trafficking and degradation. We demonstrate that the innate cellular protein homeostasis, or proteostasis, capacity can be enhanced to fold mutated enzymes that would otherwise misfold and be degraded, using small molecule proteostasis regulators. Two proteostasis regulators are reported that alter the composition of the proteostasis network in the endoplasmic reticulum through the unfolded protein response, increasing the mutant folded protein concentration that can engage the trafficking machinery, restoring function to two non-homologous mutant enzymes associated with distinct lysosomal storage diseases. Coapplication of a pharmacologic chaperone and a proteostasis regulator exhibits synergy because of the former’s ability to further increase the concentration of trafficking competent mutant folded enzymes. It may be possible to ameliorate loss-of-function diseases by using proteostasis regulators alone or in combination with a pharmacologic chaperone.
The Lancet Infectious Diseases Epidemiological, Clinical, Radiological Characteristics and Outcomes of Medical Staff with COVID-19 in Wuhan, China: A Single-centered, Retrospective Case Series Analysis

Abstract: Backgrounds Since December 2019, a novel coronavirus epidemic has emerged in Wuhan city, China and then rapidly spread to other areas. As of 20 Feb 2020, a total of 2,055 medical staff confirmed with coronavirus disease 2019 (COVID-19) caused by SARSCov-2 in China had been reported. We sought to explore the epidemiological, clinical characteristics and prognosis of novel coronavirus-infected medical staff. Methods In this retrospective study, 64 confirmed cases of novel coronavirus-infected medical staff admitted to Union Hospital, Wuhan between 16 Jan, 2020 to 15 Feb, 2020 were included. Two groups concerned were extracted from the subjects based on duration of symptoms: group 1 (≤10 days) and group 2 (>10 days). Epidemiological and clinical data were analyzed and compared across groups. The Kaplan-Meier plot was used to inspect the change in hospital discharge rate. The Cox regression model was utilized to identify factors associated with hospital discharge. Findings The median age of medical staff included was 35 years old. 64% were female and 67% were nurses. None had an exposure to Huanan seafood wholesale market or wildlife. A small proportion of the cohort had contact with specimens (5%) as well as patients in
IMPACT OF CORPORATE BOARD SIZE ON CORPORATE PERFORMANCE: EVIDENCE FROM SRI LANKA

The purpose of this is to examine the relationship between corporate board size and corporate performances of Sri Lankan listed companies. This study employs a cross sectional analysis of 109 firms listed in Colombo Stock Exchange (CSE) for the financial year ending 2013 and multivariate analyses are used to test the hypotheses. The results show that board size is significantly negatively associated with ROA and insignificantly negatively linked with ROE. Control variables of board independent, CEO duality and leverage are negatively related with ROA and ROE. Meanwhile, other variables of firm size and dividend yield are significantly positively linked with ROA and ROE. Keywordscorporate governance, board size, corporate performance, ROA, ROE
Multivoxel Neural Reinforcement Changes Resting-State Functional Connectivity Within the Threat Regulation Network

Using neural reinforcement, participants can be trained to pair a reward with the activation of specific multivoxel patterns in their brains. In a double-blind placebo-controlled experiment, we previously showed that this intervention can decrease the physiological reactivity associated with naturally feared animals. However, the mechanisms behind the effect remain incompletely understood and its usefulness for treatment remains unclear. If the intervention fundamentally changed the brain responses, we might expect to observe relatively stable changes in the functional connectivity within the threat regulation network. To evaluate this possibility, we conducted functional magnetic resonance imaging (fMRI) sessions while subjects were at rest, before and after neural reinforcement, and quantified the changes in resting-state functional connectivity accordingly. Our results indicate that neural reinforcement increased the connectivity of prefrontal regulatory regions with the amygdala and the ventral temporal cortex (where the visual representations of phobic targets are). Surprisingly, we found no evidence of Hebbian-like learning during neural reinforcement, contrary to what one may expect based on previous neurofeedback studies. These results suggest that multivoxel neural reinforcement, also known as decoded neurofeedback (DecNef), may operate via unique mechanisms, distinct from those involved in conventional neurofeedback.
A Numerical Study of Turbulent Flame Speed Development in the Spherical Case

Physical mechanisms contributing to the increase in turbulent spherical flame speed as the kernel grows are numerically studied using the Turbulent Flame Speed Closure Model. Both the timedependence of the mean reaction rate, invoked by the model, and the reduction of the curvature of the averaged kernel surface contribute to the increase at small flame radii. As the radius increases, the former effect relaxes and the latter dominates.
THE AWARENESS OF DIVERSITY AMONG THE CZECH STUDENTS AND GRADUATES

This paper deals with issue of diversity and diversity management in relation to the Czech students and graduates because diversity management is a novelty in the Czech Republic and not many people and companies knowsomething more about it. At the beginning it briefly summarizes current findings of Czech and foreign authors in this area and it shows some results from researches conducted by European Union. In the next part of this paper there is described methodology that was used for own research that is presented in this paper. The main part of this paper consists from presenting data from a questionnaire survey that examines awareness of Czech students and graduates about issues of diversity and diversity management and topics relating with it.
Notes on the combination of logical argumentation and qualitative methods in diagnosis of the built environment

Paper presents the methodology and samples of research on using the combination of logical argumentation and qualitative methods in diagnosis of the built environment. The ways of using the space­syntax analysis as an example of logical argumentation and behavioral mapping as a demonstration of qualitative research were presented in the context of a wide range of architectural research methods as well as man­environment methods.
Social dominance orientation: A personality variable predicting social and political attitudes.

Social dominance orientation (SDO), one's degree of preference for inequality among social groups, is introduced. On the basis of social dominance theory, it is shown that (a) men are more social dominance-oriented than women, (b) high-SDO people seek hierarchy-enhancing professional roles and low-SDO people seek hierarchy-attenuating roles, (c) SDO was related to beliefs in a lag number of social and political ideologies that support group-based hierarchy (e.g., meritocracy and racism) and to support for policies that have implications for intergroup relations (e.g., war, civil rights, and social programs), including new policies. SDO was distinguished from interpersonal dominance, conservatism, and authoritarianism
Effect of External Budget Deficit Financing On Economic Growth in Kenya

The trend in external borrowing by Kenyan government has been increasing while economic growth has shown fluctuating trend. External debt rose from 2.04 billion in 1970 to 1.14 trillion in 2014 . Annual growth rate was 5.9% in the period 1978-1979 and dropped to 3.1% in the period 1979-2001 and later increased to 4.4% in the period 2002-2014.Following lack of consensus from empirical perspective, relationship between external budget deficit financing and economic growth is not clear. Subsequently, despite the role of external budget deficit financing to the government financing mechanisms, there are conflicting information about their effect on economic growth. The purpose of this study was to determine the effect of external budget deficit financing mechanisms on economic growth in Kenya. The study used secondary time series data for the period 1970-2014 from Economic Survey published by Kenya National Bureau Statistics. The study was guided by neoclassical growth theory and adopted correlational research design. The models were estimated using Ordinary Least Squares method. The results indicated a negative and significant effect of external budget deficit financing on economic growth (whereβ = −0.9385;p = 0.02.). The study recommends that policies that will promote consecutive borrowing in order to reduce the negative effect of external budget deficit financing on the economy should be adopted. -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 16-05-2019 Date of acceptance: 01-06-2019 -------------------------------------------------------------------------------------------------------------------------------------
Nutrient digestibility, performance, and egg quality traits of quails raised in different stocking densities and ascorbic acid supplementation in a hot, tropical environment

This study investigated the effects of stocking density SD and ascorbic acid AA supplementation on nutrient digestibility and laying performance of quails in a tropical environment. Four hundred and eight Japanese quails were designated in a 3 × 2 factorial arrangement with four replicates. The birds were distributed to three SDs, namely 40 SD-1 , 45 SD-2 , and 50 birds per m2 SD-3 by allotting 15, 17, and 19 birds per cage, respectively cage size: 3750 cm2 . Each SD was supplemented with AA 0 and 250 mg/kg . Interaction was identified between SD and AA on egg production P < 0.01 , while the highest value was yielded in SD-2 supplemented with AA 83.6% . SD-3 achieved lower ether extract EE and crude fiber CF digestibility P < 0.05 and eggshell thickness P = 0.01 than SD-1 or SD-2. AA supplementation enhanced dry matter DM , EE, CF, crude ash CA , and calcium Ca digestibility P < 0.05 . AA improved egg weight, feed conversion, and protein and energy efficiency ratios as well as eggshell weight and thickness P < 0.05 . The SD of 45 birds per m2 , combined with AA supplementation at 250 mg/kg, can be recommended for quails housed in hightemperature environments