Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning curve of enhanced recovery after surgery program in open colorectal surgery

BACKGROUND Enhanced recovery after surgery (ERAS) reduces hospitalization and complication following colorectal surgery. Whether the experience of multidisciplinary ERAS team affects patients’ outcomes is unknown. AIM To evaluate and establish a learning curve of ERAS program for open colorectal surgery. METHODS This was a review of prospectively collected database of 380 “unselected” patients undergoing elective “open” colectomy and/or proctectomy under ERAS protocol from 2011 (commencing ERAS application) to 2017 in a university hospital. Patients were divided into 5 chronological groups (76 cases per quintile). Surgical outcomes and ERAS compliance among quintiles were compared. Learning curves were calculated based on criteria of optimal recovery: defined as absence of major postoperative complications, discharge by postoperative day 5, and no 30-d readmission. RESULTS Hospitalization more than 5 d occurred in 22.6% (n = 86), major complication was present in 2.9% (n = 11) and 30-d readmission rate was 2.4% (n = 9) accounting for unsuccessful recovery of 25% (n = 95). Conversely, the overall rate of optimal recovery was 75%. The optimal recovery significantly increased from 57.9% in 1st quintile to 72.4%-85.5% in the following quintiles (P < 0.001). Average compliance with ERAS protocol gradually increased over the time - from 68.6% in 1st quintile to 75.5% in 5th quintile (P < 0.001). The application of preoperative counseling, nutrition support, goal-directed fluid therapy, O-ring wound protector and scheduled mobilization significantly increased over the study period. CONCLUSION A number of 76 colorectal operations are required for a multidisciplinary team to achieve a significantly higher rate of optimal recovery and high compliance with ERAS program for open colorectal surgery.
The Effects of Technology Innovation Activity on CSR: Emphasizing the Nonlinear and Heterogenous Effects

In this study, we systematically investigate several effects of technology innovation activity (TIA)—proxied by Korean listed corporations’ research and development investment—on the performance of corporate social responsibility (CSR) for sustainable corporate growth and value. We find that corporate TIA positively contributes to an increase in CSR performance. Furthermore, our quantile regression estimations point to a heterogeneous effect of TIA, with a significant positive impact on CSR performance at the middle and higher quantiles of the distribution of the dependent variable of CSR performance. Interestingly, we capture a U-shaped nonlinear effect of TIA on the CSR performance of Korean listed corporations. Our findings alert researchers and managers to the importance of a better understanding of the relationship between CSR and TIA for sustainable corporate growth and value.
The relationship between social roles and psychosocial adjustment in women with AIDS: A structural equation model

Background: Acquired Immunodeficiency Syndrome/AIDS is a new social phenomenon that affects almost all the aspects of the social and economic life of individuals. The present study was conducted for the path analysis of the relationship between social roles and psychosocial adjustment in women with AIDS. Methods: This cross-sectional study was conducted in 2019 on 240 women with AIDS who referred to the Counseling Center for Behavioral Diseases of Imam Khomeini Hospital in Tehran. The eligible individuals entered the study through convenience sampling and data were collected using five questionnaires, including the Psychosocial Adjustment to Illness Scale, the Perceived Social Support Scale, the Multidimensional Health Locus of Control Scales, the Illness Perception Questionnaire, the Experiences in Close Relationship Scale and a socio-demographic checklist. Data were analyzed using SPSS-16 and Lisrel-8.8 software. Results: According to the results of the path analysis, internal health locus of control and patient's age have a significant positive relationship with psychosocial adjustment only through the direct path, and among them, patient's age has the greatest positive and direct relationship (B=0.139). In the indirect path, education, external health locus of control, anxiety in experiences of close relationships, and perceived support have the greatest relationship with psychosocial adjustment, and among these variables, education has the highest positive relationship (B=0.06). Illness perception, avoidance in experiences of close relationships and chance locus of health control are associated with psychosocial adjustment through both direct and direct paths, and among these variables, chance locus of health control has the greatest overall relationship with psychosocial adjustment (B=0.238). Conclusion: Based on the results, social roles and physical health are directly/indirectly associated with psychosocial adjustment, which emphasizes the need to pay more attention to all three aspects of psychosocial health, especially in this vulnerable group of the society
THE POTENTIAL BENEFITS OF ROUTE GUIDANCE

This report analyses the results of an inter-urban route choice study in Gloucestershire to estimate the potential benefits available to a perfect system of route guidance operating throughout Great Britain. The contribution from commuter, leisure, business and commercial vehicle journeys are considered separately. It is estimated that about L540 million was effectively wasted in Great Britain in 1979 by drivers who sought but failed to find minimum time or distance routes on unfamiliar journeys greater than 5 km in length. It is thought that this wastage represents the potential benefits available to a perfect system of route guidance. The consequent saving in vehicle-kilometres might also produce a saving in road accidents, bringing the total benefit to around L575 million per year. (a) (TRRL)
NHL Pathological Image Classification Based on Hierarchical Local Information and GoogLeNet-Based Representations

Background Accurate classification for different non-Hodgkin lymphomas (NHL) is one of the main challenges in clinical pathological diagnosis due to its intrinsic complexity. Therefore, this paper proposes an effective classification model for three types of NHL pathological images, including mantle cell lymphoma (MCL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). Methods There are three main parts with respect to our model. First, NHL pathological images stained by hematoxylin and eosin (H&E) are transferred into blue ratio (BR) and Lab spaces, respectively. Then specific patch-level textural and statistical features are extracted from BR images and color features are obtained from Lab images both using a hierarchical way, yielding a set of hand-crafted representations corresponding to different image spaces. A random forest classifier is subsequently trained for patch-level classification. Second, H&E images are cropped and fed into a pretrained google inception net (GoogLeNet) for learning high-level representations and a softmax classifier is used for patch-level classification. Finally, three image-level classification strategies based on patch-level results are discussed including a novel method for calculating the weighted sum of patch results. Different classification results are fused at both feature 1 and image levels to obtain a more satisfactory result. Results The proposed model is evaluated on a public IICBU Malignant Lymphoma Dataset and achieves an improved overall accuracy of 0.991 and area under the receiver operating characteristic curve of 0.998. Conclusion The experimentations demonstrate the significantly increased classification performance of the proposed model, indicating that it is a suitable classification approach for NHL pathological images.
PENGARUH IMPLEMENTASI KEBIJAKAN E-GOVERNMENT TERHADAP KINERJA APARATUR KOTA CIMAHI

Perkembangan teknologi, informasi dan komputer telah mempengaruhi penyelenggaraan pemerintahan di Indonesia. Pemerintah Kota Cimahi telah memanfaatkan teknologi komputer dalam upaya mewujudkan pemerintahan yang baik (good governance) melalui penerapan e-Government. Pelayanan yang baik berhubungan dengan kinerja aparatur, sehingga aparatur menjadi unsur penentu keberhasilan pemerintah dalam melayani masyarakat. Penelitian ini menggunakan desain penelitian kuantitatif dengan metode eksplanatori survey. Pengumpulan data dilakukan dengan cara pengamatan di lapangan, kuesioner, interview dan studi pustaka. Sedangkan ukuran sampel ditentukan berdasarkan probabilitas. Hasil penelitian menunjukkan bahwa implementasi kebijakan e-Government memberikan pengaruh sebesar 54,85% terhadap kinerja aparatur pemerintah di Kota Cimahi, sedangkan sisanya sebesar 45,15% merupakan pengaruh faktor-faktor lain. Hal tersebut memberikan bukti empiris bahwa semakin baik implementasi kebijakan e-Government maka semakin meningkat kinerja aparatur pemerintah di Kota Cimahi. Komunikasi, sumber daya, disposisi/sikap pelaksana, serta struktur birokrasi telah memberikan kontribusi yang berarti terhadap keberhasilan kebijakan. Hal yang paling dominan dalam implementasi kebijakan ini adalah konsistensi sikap implementor sejak perencanaan sampai dengan pengawasan mulai tingkat pimpinan puncak sampai pelaksana untuk mengimplementasikan kebijakan sesuai dengan tujuan kebijakan.
Evaluation of PicoGreen variants for use in microscopy and flow cytometry

PicoGreen is a fluorescent probe that binds dsDNA and forms a highly luminescent complex when compared to the free dye in solution. This unique probe is widely used in DNA quantitation assays but has limited application in flow cytometry and microscopy. Here we have investigated various PicoGreen variants for the ability to stain low amounts of cytosolic DNA present in many tumor cells. Analysis of stained cells by flow cytometry and fluorescent microscopy showed that certain variants improved the ability to stain low levels of cytosolic DNA when compared to the commercially available PicoGreen molecule.
Asset Pricing with Cyclical Consumption

Change in cyclical consumption can explain the market risk premium and the joint equity premium–risk-free rate puzzle with a risk aversion coefficient much lower than any consumption measures. This outperformance is robust across 18 countries. At the cross section, over the full 90-year period, change in cyclical consumption encompasses other consumption measures in explaining the variation of the returns on various portfolios and it is the only consumption measure that passes both the identification test and the GRS-Factor Anderson-Rubin test of the consumption risk premium proposed by Kleibergen and Zhan (2020). The change in cyclical consumption using only services is comparable to the Fama and French (1993) three-factor model in explaining the variation of the 25 size and book-to-market portfolio returns. ∗Department of Finance, University of Missouri-Columbia, Email: datmai@mail.missouri.edu †Department of Finance, University of Missouri-Columbia, Email: pukthuanthongk@missouri.edu
COMPARSION OF ANTHROPOMETRY AND BLOOD PRESSURE OF OBESE AND NON-OBESE POSTMENOPAUSAL WOMEN OF KARACHI, PAKISTAN

The prevalence of overweight or obesity in middle-aged women, around and after menopause is high and is rising worldwide, more rapidly in women over the age of 40 years, with up to 65% being either overweight or obese and up to 30% or more being obese. This study was planned to examine the differences in body mas index (BMI), arm circumference (Arm C), waist hip ratio (WHR) and blood pressure (BP) in obese post-menopausal women as compared to normal weight post-menopausal women. We conducted and arrange the medical camps in different localities of Karachi city. We selected age group between 40 to 55 years of females both control (n=13) and obese (n=71) with ceased menstruation for at least one year. Body weight and height was taken to calculate BMI. Blood pressure was measured in resting position of participants. A questionnaire has been designed to collect the detail information from the volunteers. Our findings evaluated the BMI (kg/m2) of obese females were significantly higher than control females (P<0.001). Arm circumferences of obese women were significantly greater (P<0.001). Comparison of mean values of WHR of both the groups showed significantly higher values in obese group (P<0.01). Both Systolic blood pressure (SBP) and diastolic blood pressure (DBP) (mmHg) of Obese postmenopausal women significantly higher (P<0.001 and P<0.01) respectively. This study found that growing issues of abdominal obesity were higher for postmenopausal women. BMI, Arm C, WHR and BP of obese postmenopausal women were significantly elevated than non-obese females.
Methodological aspects for finite element modelling of lid systems for Type B(U) transport packages

Abstract The regulatory compliance of the containment system is of essential importance for the assessment process of Type B(U) transport packages. The requirements of the International Atomic Energy Agency safety standards for transport conditions imply high loading on the containment system. The integrity of the containment system has to be ensured in mechanical and thermal tests. The containment system of German spent nuclear fuel and high level waste transport packages usually includes bolted lids with metal gaskets. The finite element (FE) method is recommended for the analysis of lid systems according to the guideline BAM-GGR 012 for the assessment of bolted lid and trunnion systems. The FE analyses provide more accurate and detailed information about loading and deformation of such kind of structures. The results allow the strength assessment of the lid and bolts as well as the evaluation of relative displacements between the lid and the cask body in the area of the gasket groove. This paper discusses aspects concerning FE simulation of lid systems for type B(U) packages for the transport of spent nuclear fuel and high level waste. The work is based on the experiences of the BAM Federal Institute for Materials Research and Testing as the German competent authority for the mechanical design assessment of such kind of packages. The issues considered include modelling strategies, analysis techniques and interpretation of results. A particular focus of this paper is on the evaluation of the results with regard to FE accuracy, influence of the FE contact formulation and FE modelling techniques to take the metallic gasket into account.
Identification of peach growth regulating-factors and their expression under UVB

Background: Growth-regulating factors (GRFs) are one of the most important plant-specific transcription factors with vital roles in multiple biological processes. GRFs have been identified in a variety of plant species, but a handful of research has addressed GRF genes in peach (Prunus persica). Results: Here, we report 46 members of the GRF family in four Rosaceae, divided into six subfamilies according to phylogeny, gene structure, and motif composition. We detected three collinear gene pairs generated from peach by whole-genome duplication or segmental duplication, but no tandem repeats were detected. Expression pattern analysis found that most PpGRFs were preferentially expressed in young tissues, At the sametime, multiple types cis-elements were observed in PpGRF promoters, and PpGRFs could positively respond to ultraviolet B-rays (UVB) and gibberellin (GA)treatments at the transcriptional level. Also, the content of GA3 and indole-3-acetic acid (IAA) changed significantly after UVB irradiation, indicating that GRFs might be involved in new shoot development in peach.Conclusions: This study identified 10 GRF genes in the peach genome and systematically analyzed their properties, thereby providing a foundation for researchers to have a better understanding of this gene family in peach. PpGRF 3, 4, 5, 6, 7, 9, and 10 positive responses to UVB and GA3 signals indicate that they can serve as candidate functional genes to further study how tree potential is regulated in peach.
Characterization of mainstream cigarette smoke aerosol by size-fractionated chemical analysis of nicotine, solanesol, and tobacco-specific nitrosamines

Abstract The distribution of key chemicals in mainstream cigarette smoke (MCS) particles of different sizes have implications for respiratory dose. In this study, a differential mobility spectrometer (DMS) and an electrical low-pressure impactor (ELPI) were used to characterize MCS particles generated from three cigarettes (3R4F, Dunhill, and Hongtashan). In addition, the ELPI was used to collect smoke particles of three different aerodynamic diameters (144, 431, and 722 nm) from 3R4F MCS, which were analyzed for nicotine, solanesol and tobacco-specific nitrosamines (TSNAs). The number concentration, particle size distribution, and count median diameter (CMD) of the MCS particles characterized by DMS and ELPI were compared quantitatively. The observed difference in the physical characterization results of MCS particles may be due to a myriad of discrepancies between the two techniques. Chemical analyses of the three ELPI selected particle sizes showed that, after normalization to total particulate matter (TPM), nicotine and TSNAs were distributed evenly, whereas solanesol showed a tendency to increase with increasing particle diameter. Notably, the distribution of nicotine and four TSNAs was independent of the three particle sizes; however, the amount of solanesol showed a slight dependency on particle size, varying by less than 23.4% over the size range considered.
AF1q inhibited T cell attachment to breast cancer cell by attenuating Intracellular Adhesion Molecule-1 expression

Aim: To investigate whether AF1q, overexpressed in metastatic cells compared with the primary tumor cells, plays a pivotal role in breast cancer metastasis. Methods: To investigate whether AF1q has a responsibility in the acquisition of a metastatic phenotype, we performed RNA-sequencing (RNA-Seq) to identify the gene signature and applied the Metacore direct interactions network building algorithm with the top 40 amplicons of RNA-Seq. Results: Most genes were directly linked with intercellular adhesion molecule-1 (ICAM-1). Likewise, we identified that ICAM-1 expression is attenuated in metastatic cells compared to primary tumor cells. Moreover, overexpression of AF1q attenuated ICAM-1 expression, whereas suppression of AF1q elicited the opposite effect. AF1q had an effect on ICAM-1 promoter region and regulated its transcription. Decreased ICAM-1 expression affected the attachment of T cells to a breast cancer cell monolayer. We confirmed the finding by performing the analysis on Burkitt’s lymphoma. Conclusion: Attenuation of ICAM-1 by AF1q on tumor cells disadvantages host anti-tumor defenses through the trafficking of lymphocytes, which affects tumor progression and metastasis.
Mapping E-Science's Path in the Collaboration Space: An Ontological Approach to Monitoring Infrastructure Development

In an undertaking such as the U.S. Cyberinfrastructure Initiative, or the UK e-science program, which span many years and comprise a great many projects funded by multiple agencies, it can be very difficult to keep tabs on what everyone is doing. But, it is not impossible. In this paper, we propose the construction of ontologies as a means of monitoring a research program’s portfolio of projects. In particular, we introduce the “virtual laboratory ontology” (VLO) and show how its application to e-Science yields a mapping of the distribution of projects in several dimensions of the “collaboration space. ” In this paper, we sketch out a method to induce a project mapping from project descriptions and present the resulting map for the UK e-science program. This paper shows the proposed mapping approach to be informative as well as feasible, and we expect that its further development can prove to be substantively useful for future work in cyber-infrastructure-building.
The moderating and mediating effect of the environmental management control systems on environmental performance : the case of Malaysian hotel sector

This study seeks to contribute to the field of environmental management and management control literature as the study resolves the existing conflicts in the literature regarding environmental management practice and at the same time develops a theoretical foundation for the management control system in the framework of the environmental management perspective. This study also introduces the moderating and mediating framework to enhance the understanding of the contingent factor related to the practice-control relationship in the environmental management perspective. Previous studies such as Henri and Journeault (2006) and Baba (2004) examined environmental management practices within manufacturing firms, thus ignoring the significant impact of the service-based sector on environmental problems. Building from Simons's (1995) four levers of management control system, this study examines empirically the influence of environmental management control systems on environmental performance in the hotel sector. This study used questionnaires and phone interview surveys to collect the data. Linear regression analysis and hierarchical (moderated) multiple regression analysis are used to analyse the data. Environmental management practice and four elements of management control systems, i. e. interactive control systems, budgeting control systems, environmental information systems and cultural control systems, are considered to have a significant influenced on environmental performance. Size, structure and chain are also included in the model as control variables. The results indicate that management control systems are not necessarily applicable in assisting hotel management to enhance their environmental performance. The budgeting control system was the only management control element which directly influences environmental performance. Environmental management practice is found not to have a direct significant effect on environmental performance. However, the results reveal that the budgeting control system and interactive control system mediate the relationship between environmental management practice and envirom-nental performance, while the environmental information system and cultural control system moderate the relationship. The results of the study are expected to have implications on the awareness in the hotel sector of how important it is for hotels to practise environmental activities beyond-compliance and integrate them with management control systems to improve their environmental performance.
MODEL PREDICTIVE CONTROL FOR NONLINEAR TIME-DELAY SYSTEMS

Abstract This paper presents a model predictive controller with guaranteed closed-loop stability for nonlinear time-delay systems. The basic idea of the proposed nonlinear model predictive control (NMPC) scheme is based on previous results in NMPC for systems without delayed states. In particular, an expanded zero terminal state constraint, that takes the delayed states of the system into account, is used in order to guarantee closed-loop stability. The applicability of the proposed NMPC controller is demonstrated considering the control of a continuous stirred tank reactor with recycle stream.