Miracle-dz/UniFAR-FTUs huggingface dataset:
Automatable Distributed Regression Analysis of Vertically Partitioned Data Facilitated by PopMedNet: Feasibility and Enhancement Study

Background In clinical research, important variables may be collected from multiple data sources. Physical pooling of patient-level data from multiple sources often raises several challenges, including proper protection of patient privacy and proprietary interests. We previously developed an SAS-based package to perform distributed regression—a suite of privacy-protecting methods that perform multivariable-adjusted regression analysis using only summary-level information—with horizontally partitioned data, a setting where distinct cohorts of patients are available from different data sources. We integrated the package with PopMedNet, an open-source file transfer software, to facilitate secure file transfer between the analysis center and the data-contributing sites. The feasibility of using PopMedNet to facilitate distributed regression analysis (DRA) with vertically partitioned data, a setting where the data attributes from a cohort of patients are available from different data sources, was unknown. Objective The objective of the study was to describe the feasibility of using PopMedNet and enhancements to PopMedNet to facilitate automatable vertical DRA (vDRA) in real-world settings. Methods We gathered the statistical and informatic requirements of using PopMedNet to facilitate automatable vDRA. We enhanced PopMedNet based on these requirements to improve its technical capability to support vDRA. Results PopMedNet can enable automatable vDRA. We identified and implemented two enhancements to PopMedNet that improved its technical capability to perform automatable vDRA in real-world settings. The first was the ability to simultaneously upload and download multiple files, and the second was the ability to directly transfer summary-level information between the data-contributing sites without a third-party analysis center. Conclusions PopMedNet can be used to facilitate automatable vDRA to protect patient privacy and support clinical research in real-world settings.
Shrinking lung syndrome in pediatric systemic lupus erythematosus

Shrinking Lung Syndrome (SLS) is a rare and little known complication associated with Systemic Lupus Erythematosus (SLE), characterized by progressive and unexplainable dyspnea, pleuritic pain, small pulmonary volumes and elevation of the diaphragm on chest X-rays as well as restrictive pattern on pulmonary function tests. Objective To describe clinical, radiological and treatment characteristics in pediatric patients with SLS. Material and methods This is a descriptive and retrospective study in patients under 16 years old with the diagnosis of SLE complicated by SLS at the General Hospital. National Medical Center La Raza. Clinical, radiological and treatment variables were analyzed. Results are shown in frequencies and percentages. Results Data from 11 patients, 9 females and 2 males were collected. Mean age at diagnosis of SLS was 12.2 years. Age at diagnosis of SLE was 11.1 years. SLEDAI 17.3. Renal desease 72%, hematological 91%, lymphopenia 63%, mucocutaneous 72%, neurological 9%, arthritis 54%, serositis 91%, fever 81%, secondary antiphospholipid syndrome, low C3 72%, low C4 81%, positive ANA 91%, positive anti-DNA 91%. Regarding clinical manifestations of SLE: cough 81%, dyspnea 91%, hipoxemia 81%, pleuritic pain 71%, average oxygen saturation 83%. Chest X-rays findings: right hemidiaphragm affection 18%, left 63%, bilateral 18%. Elevated hemidiaphragm 91%, atelectasis 18%, pleural effusion 91%, over one third of the cardiac silhouette under the diphragm 36%, bulging diaphragm 45%, 5th. anterior rib that crosses over the diaphragm 91%. M-mode ultrasound: diaphragmatic hypomotility 100%, pleural effusion 63%. Pulmonary function tests: restrictive pattern in 45% of the cases. Treatment was with supplementary oxygen 100%, intubation 18%, antibiotics 100%, steroids 100%, intravenous immunoglobulin 54%, plasmapheresis 18%, cyclophosphamide 54% and rituximab 18%. The clinical course was favorable in 81%. Conclusions SLS should be suspected in patients with SLE and active disease who present hipoxemia, pleuritic pain, cough, dyspnea, pleural effusion and signs of restriction on chest X-rays. Therefore, a diaphragmatic M-mode ultrasound should be performed in order to establish the diagnosis.
Distorted self-perception and dissatisfaction with body image among nursing students.

OBJECTIVE To evaluate distorted self-perception and dissatisfaction with body image among nursing students. METHOD Cross-sectional study with students from a public university. Self-perception and satisfaction with body image were assessed using the Figure Rating Scale and the Body Shape Questionnare (BSQ). Body Mass Index was calculated with self-reported weight and height. Analysis was processed in Stata 15.0 with a significance level of 5%. RESULTS A total of 93 students participated in the study. Results showed 87.1% of distorted self-perception, with a greater proportion of students who overestimated their body size (68.8%); 89.2% of students were dissatisfied with their body image according to the Figure Rating Scale, and 55.9% according to the BSQ. Dissatisfaction assessed by the BSQ was associated with biological sex, nutritional status, diets and bullying. CONCLUSION The results indicate the need to address the theme in the training of nurses, to help them accept their own bodies and to enable them to act effectively in their professional practice.
Cardiac Corrected QT Interval Changes Among Patients Treated for COVID-19 Infection During the Early Phase of the Pandemic

Key Points Question Is infection with COVID-19 associated with prolonged corrected QT interval (QTc) on electrocardiogram in hospitalized patients? Findings In this cohort study of 965 patients with and without COVID-19 infection, multivariable modeling showed that COVID-19 positivity was associated with significant mean QTc prolongation from baseline during a 5-day observation period compared with no significant mean QTc change in patients without COVID-19. A greater proportion of patients with COVID-19 infection had incidence of QTc of 500 milliseconds or greater compared with patients without COVID-19 infection. Meaning In this study, COVID-19 infection was associated with significant mean QTc prolongation from baseline, independent of common clinical factors associated with QTc prolongation.
Position preference of essential genes in prokaryotic operons

Essential genes, which form the basis of life activities, are crucial for the survival of organisms. Essential genes tend to be located in operons, but how they are distributed in operons is still unclear for most prokaryotes. In order to clarify the general rule of position preference of essential genes in operons, an index of the average position of genes in an operon was proposed, and the distributions of essential and non-essential genes in operons in 51 bacterial genomes and two archaeal genomes were analyzed based on this new index. Consequently, essential genes were found to preferentially occupy the front positions of the operons, which tend to be expressed at higher levels.
Advanced organic-inorganic hybrid fillers as functional additives for poly(vinyl chloride)

Functional hybrid fillers (kraft lignin conjugated with Sylobloc® 41 silica) were obtained using a process of mechanical grinding of precursors. The products underwent comprehensive physicochemical and dispersive-morphological analysis. The organic-inorganic fillers have good homogeneity and a relatively high surface area. Composites of rigid poly(vinyl chloride) as a matrix with these specific dual fillers were produced in molten state. Data on the processing properties of the blends show the beneficial impact of fillers on gelation time. The presence of lignin/silica fillers strongly influences the thermal stability of PVC as well as Vicat softening temperature.
Leadless pacemaker versus transvenous single-chamber pacemaker therapy: peri-procedural aspects, utilization of medical resources and patient acceptance

ABSTRACT Background Leadless pacemaker (L-PM) have been developed in order to overcome the lead- and pocket-related complications associated with transvenous pacemaker (T-PM). The impact of L-PM implantation on the utilization of medical resources, patient comfort and therapy acceptance could differ from that of T-PM. Research design and methods Prospective, single-center study enrolling 243 consecutive patients undergoing PM implantation. Propensity matching for baseline characteristics yielded 77 matched pairs. Procedural data, patient acceptance (assessed by Florida Patient Acceptance Survey, FPAS) and quality of life (QoL) (assessed at the baseline, 1 week, 3 and 6 months) were compared between the two groups (L-PM and T-PM). Results The implantation procedure was longer in L-PM than T-PM patients (42.2±16.3 vs. 28.9±11.9 minutes; p<0.001). L-PM was associated with lower intra- and post-operative pain intensity (all p<0.05), shorter hospitalization (3.2±0.5 vs. 3.5±1.1 days; p=0.034), greater patient acceptance (FPAS score: 58.7±7.1 vs. 40.5±4.1; p<0.001), and better QoL on both physical and mental health scales (all p<0.05). Conclusions Although L-PM implantation takes longer than T-PM, it is better tolerated and accepted by patients and is associated with a better QoL.
Fluorwavellite, Al3(PO4)2(OH)2F·5H2O, the fluorine analog of wavellite

Abstract Fluorwavellite (IMA2015-077), Al3(PO4)2(OH)2F·5H2O, the F analog of wavellite, is a new mineral from the Silver Coin mine, Valmy, Iron Point district, Humboldt County, Nevada, and the Wood mine, 5 miles NE of Del Rio, Cocke County, Tennessee; at both occurrences it is a low-temperature secondary mineral. Fluorwavellite is essentially identical to wavellite in appearance and physical properties. Optically, fluorwavellite is biaxial positive, with α = 1.522(1), β = 1.531(1), and γ = 1.549(1) (white light). Electron microprobe analyses (average of nine for each co-type locality) provided the empirical formulas Al2.96(PO4)2(OH)1.98F1. 02·5H2O (+0.12 H) for the Silver Coin mine and Al2.98(PO4)2(OH)2.11F0. 89·5H2O (+0.06 H) for the Wood mine. Fluorwavellite is orthorhombic, Pcmn, with the cell parameters determined on a Wood mine crystal: a = 9.6311(4), b = 17.3731(12), c = 6.9946(3) Å, V = 1170.35(11) Å3, and Z = 4. The five strongest lines in the X-ray powder diffraction pattern are [dobs in Å (I) (hkl)]: 8.53 (100) (020,110); 5.65 (26) (101); 3.430 (28) (141,012); 3.223 (41) (240); and 2.580 (28) (331,161,232). The structure of fluorwavellite (R1 = 3.42% for 1248 Fo > 4σF reflections) is the same as that of wavellite, differing only in having one of the two independent hydroxyl sites replaced by F. A survey of F contents in wavellite-fluorwavellite from the five most common genetic types of occurrence (fluid expulsion, hydrothermal ore alteration, pegmatite phosphate alteration, residual carbonate weathering, and sedimentary leached zone) shows that F content, and the occurrence of wavellite vs. fluorwavellite, does not correlate with the type of the occurrence. It is more likely related to the fluid activity of Al, P, and F, with pH probably being an important factor. The role that wavellite and fluorwavellite play in sequestering F in the environment may be significant.
Narrative review of the multisensory integration tasks used with older adults: inclusion of multisensory integration tasks into neuropsychological assessment

ABSTRACT Introduction: Age-related changes in sensory functioning impact the activities of daily living and interact with cognitive decline. Given the interactions between sensory and cognitive functioning, combining multisensory integration (MI) assessment with the neuropsychological assessment of older adults seems promising. This review aims to examine the characteristics and utility of MI tasks in functional and cognitive assessment of older adults, with or without neurocognitive impairment. Areas covered: A literature search was conducted following the quality assessment of narrative review criteria. Results focused on tasks of detection, discrimination, sensory illusion, temporal judgment, and sensory conflict. Studies were not consensual regarding the enhancement of MI with age, but most studies showed that older adults had an expanded time window of integration. In older adults with mild cognitive impairment or major neurocognitive disorder it was a mediating role of the magnitude of visual-somatosensory integration between neurocognitive impairment and spatial aspects of gait. Expert opinion: Recently, some concerns have been raised about how to maximize the ecological validity of the neuropsychological assessment. Since most of our activities of daily living are multisensory and older adults benefit from multisensory information, MI assessment has the potential to improve the ecological validity of the neuropsychological assessment.
GlucoSTRESS - A project to optimize glycemic control in a level C (III) Portuguese intensive care unit

Objective To double the percentage of time within the 100 - 180mg/dL blood glucose range in the first three months following a phased implementation of a formal education program, and then, of an insulin therapy protocol, without entailing an increased incidence of hypoglycemia. Methods The pre-intervention glycemic control was assessed retrospectively. Next, were carried out the implementation of a formal education program, distribution of manual algorithms for intravenous insulin therapy - optimized by the users, based on the modified Yale protocol - and informal training of the nursing staff. The use of electronic blood glucose control systems was supported, and the results were recorded prospectively. Results The first phase of the program (formal education) lead to improvement of the time within the euglycemic interval (28% to 37%). In the second phase, euglycemia was achieved 66% of the time, and the incidence of hypoglycemia was decreased. The percentage of patients on intravenous insulin infusion at 48 hours from admission increased from 6% to 35%. Conclusion The phased implementation of a formal education program, fostering the use of electronic insulin therapy protocols and dynamic manuals, received good adherence and has shown to be safe and effective for blood glucose control in critically ill patients, with a concomitant decrease in hypoglycemia.
SERS studies of carbon nanotubes on silver substrate

According to the remarkable mechanical property, carbon nanotubes (CNTs) were grinded on a sheet of silver directly. Thus rough silver surface was obtained, at the same time, the CNTs attached to the rough silver surface. High quality Surface-enhanced Raman Scattering (SERS) spectra were obtained from CNTs attached to the rough silver surface. At the present time, in the works on SERS of CNTs[1-6], CNTs were always ultra sonicated in solvent firstly, and then added into metallic colloidal clusters or dropped on rough metallic surface for forming the SERS system. And many results have been observed. It is well known that the solvent is an important factor which impacts the SERS of CNTs. The dependability of the result is reduced when the solvent was induced into the SERS system. If there is no solvent in the SERS system, the dependable of the results can increase greatly. In order to set up a SERS system without solvent, we grinded CNTs on silver foil directly according to the particular structure and remarkable mechanical property of CNTs. Thus a no solvent SERS system was obtained. The theory and experiment results indicate that this method is exactitude and practicable. The Raman (a) and SERS (b) spectra of SWCNTs are presented in fig.1. As shown in fig.1 the RBM is at 201cm. According to the equation [7], the diameter of SWCNTs is about1.23nm. •RBM=248/dt (cm) (1) In fig.1a, the RBM is broad and weak, and in the frequency range 1500-1600cm, only one band is observed at 1580cm, with a shoulder at 1560cm. In the SERS spectrum (fig.1b), the RBM becomes more narrow and stronger. The GM is enhanced highly and splits into three lines (1554cm•1563cm • 1585cm). Remarkably, in fig.1b, for the system we used not including solvent completely, we observed that the line at 1550cm has a full figure and it’s intensity is stronger than that of the line at 1565cm, which were different from former literatures [1-6] in which solvent was used. In reports [1-6], the line at ~ 1550cm is a shoulder or a weak peak, which intensity was more weaker than that of the line at ~ 1565cm. And the relative intensity of the line at 1550cm to the one at 1565cm was affected by the solvents. In report [3], when toluene is used as solvent the line at ~ 1550cm is a shoulder, but when THF is used as toluene, it was a weak peak. We think some lines in the SERS spectra of the SWCNTs maybe Raman lines of the solvents or the superposition of the solvents and SWCNTs when solvents were used in the experiment, and the dependability of the results was reduced. In this report, the system without solvents completely, and we observed that the intensity of the line at 1550cm was stronger than that of the line at1565cm.In this report, the system without solvents completely, and we observed that the intensity of the line at 1550cm was stronger than that of the line at1565cm. Table1 shows the position, intensity and vibrational mode for the Raman lines in fig.1b.
Play Behavior in Two Captive Bottlenose Dolphin Calves (Tursiops Truncatus): Ethogram, Ontogeny, and Individual Differences

ABSTRACT This research focused on different aspects of play behavior including ethogram, ontogeny, and individual differences, in one male and one female captive bottlenose dolphin calves (Tursiops truncatus) from November 2003 to June 2004. We presented the first peer-reviewed description of a play ethogram in bottlenose dolphin calves whose behaviors were grouped into three hierarchical levels: two categories: solitary and social play; four subcategories: locomotor, object, bubble play, and in the presence of humans, and 35 entries. It was conducted in two phases: the descriptive phase – from 3 to 5 months old – with 29 entries and the quantitative phase – from 6 to 10 months old –with six entries. All social and solitary locomotor behaviors appeared when animals were 3 months old meanwhile more complex behaviors concerning playing with objects, bubbles, and in the presence of humans were observed for 6 months old. There were no statistically significant intra-individual and inter-individual differences in the play behavioral diversity, in the time invested in play and in the Shannon’s evenness index. However, we observed statistically significant inter-individual but not intra-individual differences for the Shannon’s diversity index.
Knowledge, attitude, and practices of grassroot health workers about early childhood caries.

OBJECTIVE This study examines the knowledge levels pertaining to early childhood caries (ECC) among grassroot workers of rural India. DESIGN A questionnaire study assessing the awareness levels of various ECC aspects was carried out among 88 auxiliary nurse midwives (ANMs), 140 Anganwadi workers (AWWs), and 210 Accredited Social Health Activist (ASHA) workers in a district of Southern India. A 24-item pretested, structured, and close-ended, self-administered questionnaire was used to collect information on the knowledge of early childhood oral health-related factors. Descriptive statistics and multivariate ANOVA were used to summarize the results. RESULTS Overall, only 59% of ANMs, 49% of AWWs, and 47% of ASHA workers were found to have adequate knowledge about ECC. CONCLUSION The current study clearly highlighted the discrepancy in the awareness levels among grassroot health care workers. A deficit was found to exist in the knowledge of the tested health care workers regarding infant oral care and ECC transmissibility.
Sensitivities of Ozone Air Pollution in the Beijing-Tianjin-Hebei Area to Local and Upwind Precursor Emissions Using Adjoint Modeling.

Effective mitigation of surface ozone pollution entails detailed knowledge of the contributing precursors' sources. We use the GEOS-Chem adjoint model to analyze the precursors contributing to surface ozone in the Beijing-Tianjin-Hebei area (BTH) of China on days of different ozone pollution severities in June 2019. We find that BTH ozone on heavily polluted days is sensitive to local emissions, as well as to precursors emitted from the provinces south of BTH (Shandong, Henan, and Jiangsu, collectively the SHJ area). Heavy ozone pollution in BTH can be mitigated effectively by reducing NOx (from industrial processes and transportation), ≥C3 alkenes (from on-road gasoline vehicles and industrial processes), and xylenes (from paint use) emitted from both BTH and SHJ, as well as by reducing CO (from industrial processes, transportation, and power generation) and ≥C4 alkanes (from industrial processes, paint and solvent use, and on-road gasoline vehicles) emissions from SHJ. In addition, reduction of NOx, xylene, and ≥C3 alkene emissions within BTH would effectively decrease the number of BTH ozone-exceedance days. Our analysis pinpoint the key areas and activities for locally and regionally coordinated emission control efforts to improve surface ozone air quality in BTH.
Body shape transformations by alternate anatomical adaptive peak shifts in blenniiform fishes

Extreme body elongation has occurred repeatedly in the evolutionary history of ray‐finned fishes. Lengthening of the anterior‐posterior body axis relative to depth and width can involve changes in the cranial skeleton and vertebral column, but to what extent is anatomical evolution determined by selective factors and intrinsic constraints that are shared broadly among closely related lineages? In this study, we fit adaptive (Ornstein‐Uhlenbeck) evolutionary models to body shape and its anatomical determinants and identified two instances of extreme elongation by divergent anatomical peak shifts in the Blenniiformes, a radiation of small‐bodied substrate‐associated marine teleost fishes. Species in the genus Xiphasia (hairtail blennies) evolved toward a peak defined by a highly elongated caudal vertebral region but ancestral cranial and precaudal vertebral morphology. In contrast, a clade that includes the genera Chaenopsis and Lucayablennius (pike and arrow blennies) evolved toward a peak with a long slender skull but ancestral axial skeletal anatomy. Neither set of anatomical peak shifts aligns closely with the major axis of anatomical diversification in other blenniiform fishes. These results provide little evidence that ancestral constraints have affected body shape transformation, and instead suggest that extreme elongation arose with distinct shifts in selective factors and development.