Miracle-dz/UniFAR-FTUs huggingface dataset:
Ractopamine hydrochloride on performance and carcass traits of confined Nellores cattle

Avaliou-se o efeito de quatro niveis de inclusao (0; 450; 900 e 1.350g T-1) do cloridrato de ractopamina, sobre o ganho de peso, a conversao alimentar, o consumo de materia seca, as caracteristicas de carcaca e a qualidade de carne de bovinos machos castrados em confinamento. Foram utilizados 40 bovinos da raca Nelore, com idade media de 26 meses e peso medio inicial de 423,4±2,7kg, em um delineamento experimental em blocos casualizados, com quatro tratamentos e dez repeticoes. A dieta foi fixada obedecendo-se razao volumoso:concentrado de 75,3:24,7 na materia seca. Observou-se efeito linear positivo da inclusao da ractopamina sobre o ganho de peso diario e efeito linear negativo sobre a conversao alimentar, com destaque para as melhorias com o aumento da inclusao do cloridrato de ractopamina. Em relacao as caracteristicas de carcaca, observou-se o efeito linear negativo para a espessura de gordura e nao foram observadas diferencas quanto ao peso da carcaca quente; rendimento de carcaca; area, largura e profundidade de area de olho de lombo do musculo Longissimus dorsi, e cortes nobres. Em relacao ao consumo de materia seca, a comparacao dos tratamentos demonstrou que a ractopamina nao influencia negativamente no consumo, o que evidencia seu efeito positivo no desempenho animal. O uso do cloridrato de ractopamina melhora o desempenho e diminui a quantidade de gordura superficial na carcaca de bovinos machos nelore em confinamento.
Glutamate and Glutamine in the Brain Compartmentation of Brain Glutamate Metabolism in Neurons and Glia 1 , 2

Intrasynaptic [glutamate] must be kept low in order to maximize the signal-to-noise ratio after the release of transmitter glutamate. This is accomplished by rapid uptake of glutamate into astrocytes, which convert glutamate into glutamine. The latter then is released to neurons, which, via mitochondrial glutaminase, form the glutamate that is used for neurotransmission. This pattern of metabolic compartmentation is the “glutamateglutamine cycle. ” This model is subject to the following two important qualifications: 1) brain avidly oxidizes glutamate via aspartate aminotransferase; and 2) because almost no glutamate crosses from blood to brain, it must be synthesized in the central nervous system (CNS). The primary source of glutamate carbon is glucose, and a major source of glutamate nitrogen is the branched-chain amino acids, which are transported rapidly into the CNS. This arrangement accomplishes the following: 1) maintenance of low external [glutamate], thereby maximizing signal-to-noise ratio upon depolarization; 2) the replenishing of the neuronal glutamate pool; 3) the “trafficking” of glutamate through the extracellular fluid in a nonneuroactive form (glutamine); 4) the importation of amino groups from blood, thus maintaining brain nitrogen homeostasis; and 5) the oxidation of glutamate/glutamine, a process that confers an additional level of control in terms of the regulation of brain glutamate, aspartate and g-aminobutyric acid. J. Nutr. 130: 1026S–1031S, 2000.
Impact of Journaling on Students' Self-Efficacy and Locus of Control.

While considerable research has examined the academic and cognitive value of journaling, little has examined the psychological impact of journaling on the personal development of college students. Research on cognitive-behavioral therapy indicates that journaling can have a positive impact on individuals’ self-growth and intrapersonal characteristics. The purpose of this study is to examine the impact of classroom-based journaling on students’ self-efficacy and locus of control. Students in two undergraduate courses were required to complete weekly journal assignments; one class received targeted information on cognitive-behavioral therapy (CBT) and one class did not. Students completed pre-, mid-, and postcourse assessments on self-efficacy, locus of control, and learning. Results revealed that self-efficacy scores for both groups significantly improved after the early journaling assignments; however, there were no differences between those who received direct CBT instruction and those who did not. These findings indicate that journaling may have important psychological benefits above and beyond its expected academic and cognitive outcomes.
Verification of Quranic Verses in Audio Files using Speech Recognition Techniques

Al-Quran is the holy book of Muslims which is written and recited in Arabic language, the language in which it was revealed. Muslims believe that the Quran is neither corrupted nor altered this is mainly due to maintaining its original text. It is forbidden to recite the Quran in any other language apart from Arabic with neither additions nor subtractions. However with the proliferation of technology especially the Internet and social media sites such as Facebook and Twitter, the spread of mistakenly or deliberately distorted audio clips are witnessed regularly. In this regard, it is necessary to preserve the authenticity and integrity of the Quran from all sorts of corruption. This paper therefore proposes speech recognition technique that will be used for verification of the Quran verses online
Germination Ecology of Catchfly (Silene conoidea) Seeds of Different Colors

ABSTRACT - Catchfly ( Silene conoidea ), an annual herb, is usually recognized asan emerging weed species in Eurasia and North America. The presence of somaticseed polymorphism might aid in the adaptation of this weed in different climaticconditions. We conducted laboratory and greenhouse experiments to study theseed polymorphism and influence of various environmental factors like temperature,salt stress, osmotic stress and burial depth on the germination and emergencecharacteristics of catchfly. Optimum germination of seeds of all colors was recordedat a temperature of 15 o C. Germination of catchfly seeds of all colors followeddecreasing trend as NaCl concentration increased from 50 mM to 200 mM. Seedgermination was maximum (87-96%) at 0 MPa but gradually decreased to 40% asosmotic stress increases up to -0.4 MPa and completely inhibited at 0.6 MPa of allseed colors. A slight increase (from 60 to 95%) in the germination of seeds of blackand dark brown colors was observed when seeding depth increased from 0 to 2 cmbut decreased when seeding depth increased from 2 to 4 cm in seeds of all colors.There was no emergence of catchfly at seeding depth of 6 cm or greater. Our resultsconcluded that catchfly seeds have the potential to germinate and emerge in variousenvironmental conditions, but germination/emergence percentage of seeds of allcolors will be different in different environmental conditions. Soil amendmentsincluding deep ploughing may aid for the successful management of this weed incultivated areas.
Effect of Service Quality on Student Satisfaction on SMEs: The Case of Private Schools in Egypt

Focus of this research on assessing quality from a student’s perspective in private education. by examining the effect of Service quality dimensions on satisfaction of students enrolled into private languages schools in Egypt in SMEs schools, private education sector. SMEs business goals match larger organizations business goals. Among these goals are raising customer satisfactions, achieving high performance, providing quality service to increase their market share. The objectives of this research art first to identify the quality dimensions most vital to students in a developing country such as Egypt, and then to develop a framework consisting of these dimensions; and second, to investigate the extent of satisfaction of students enrolled into private languages schools in Egypt. This research will follow applied research approach. The methodology based on quantitative analysis by using a questionnaire tool for data collection. The results indicated that most of hypotheses were supported by model structural equation modelling analyses (SEM). The main conclusions drawn from this study are Service quality has partial significant positive effect on students satisfaction in private languages schools in Egypt in SMEs schools. Towards measuring the influence that each driver has on student satisfaction and its importance to the students, with school image being the most highly rated dimension. Followed by Tangibles then Assurance and Empathy respectively (in order of importance).
CHAPTER TEN ACQUISITION OF LOCATIVE EXPRESSIONS IN CHILDREN LEARNING

In sign languages, where space is often used to talk about space, expressions of spatial relations may rely on analogue mappings of real space onto signing space. In contrast, spoken languages express space in mostly categorical ways (e.g., adpositions). Whether and to what extent modality influences the acquisition of spatial language is controversial – mostly due to the lack of direct comparisons of deaf children to deaf adults and to age-matched hearing children in similar tasks. Furthermore, previous studies have taken mostly western languages as the model for spoken language development of spatial relations. Therefore, we compare the spatial expressions elicited from Turkish deaf children acquiring Turkish Sign Language (TİD) natively and hearing children acquiring Turkish in two different age-matched groups (preschool age and school age), as well as to those of adults. All participants described three topological spatial configurations (IN, ON, UNDER) of different objects (e.g., apple in box; pen on table). The analysis of the descriptions of these spatial relations does not suggest an effect of modality on the development of static spatial expressions in TİD and Turkish since the deaf children * This work has been supported by European Research Council Starting Grant (ERC) and NWO VIDI grant given to the fourth author as well as by the Max Planck Institute for Psycholinguistics, Nijmegen. We would like to thank Türkiye İşitme ve Konuşma Rehabilitasyon Vakfı (TİV) and Dosteller İşitme Engelliler Erken Çocukluk Eğitim Merkezi Anaokulu ve İlköğretim Okulu in İstanbul for their support in providing logistics for the study to be carried out.
CRASH REDUCTIONS FOLLOWING INSTALLATION OF ROUNDABOUTS IN THE UNITED STATES

Modern roundabouts are designed to control traffic flow at intersections without the use of stop signs or traffic signals. U.S. experience with modern roundabouts is rather limited to date, but in recent years there has been growing interest in their potential benefits and a relatively large increase in roundabout construction. The present study evaluated changes in motor vehicle crashes following conversion of 24 intersections from stop sign and traffic signal control to modern roundabouts. The settings, located in 8 states, were a mix of urban, suburban, and rural environments. A before-after study was conducted using the empirical Bayes approach, which accounts for regression to the mean. Overall, the empirical Bayes procedure estimated highly significant reductions of 39% for all crash severities combined and 76% for all injury crashes. Reductions in the numbers of fatal and incapacitating injury crashes were estimated to be about 90%. Overall, results are consistent with numerous international studies and suggest that roundabout installation should be strongly promoted as an effective safety treatment for intersections.
Determinants in detecting fraud triangle of financial statements on companies registered in Jakarta Islamic Index (JII) period 2012-2018

Purpose - The purpose of study was to examine the effect financial statement fraud based on the fraud triangle with a number of variables such as financial stability, external pressure, financial target, personal financial needs, opportunity and rasionalization in companies listed in Jakarta Islamic Index (JII) period 2012-2018. Method - The population are all companies listed in JII period 2012-2018. The sample is 6 companies that were feasible to analyze. The data used in this research is secondary data obtained from the annual report. The data analysis model applied multiple linier regression data panel using SPSS 25. Result - The results showed that the fraud triangle in the categories of financial stability, external pressure, financial targets, personal financial needs, opportunity and rationalization simultaneously affect the fraudulent financial statements. Furthermore financial stability, personal financial needs and opportunity partially negatively related and had no significant effect on financial statement fraud; while external pressures, financial targets and rationalization have positive and significant effects on financial statement fraud on companies listed in JII period 2012-2018. Implication - Companies Registered in JII are suggested to improve the financial performance in accordance with sharia principles. Originality - This research is the first study using multiple linier regression data panel.
Genetic diversity and interspecific relations of western Mediterranean relic Abies taxa as compared to the Iberian

Several Abies species are currently present in the Mediterranean Region and most of them are endemits and Tertiary relicts. Using six nuclear microsatellites, we studied the genetic structure and inter-specific relationships among West Mediterranean firs, A. pinsapo (Spain), A. maroccana and A. tazaotana (Morocco). Based on the hypothesis that A. pinsapo could historically exchange genes with A. alba growing in the Pyrenees via secondary contact, we investigated the level of genetic admixture between these species using a Bayesian approach. The studied populations showed moderate genetic diversity (mean HE = 0.598) and a high level of genetic differentiation (FST = 0.225) that was especially pronounced between A. alba and African firs. All populations experienced a strong bottleneck effect that was likely induced by climatic changes occurring in the west Mediterranean during the last glacial cycle and the Holocene. According to Bayesian clustering, both African taxa grouped together in a single cluster, the two A. pinsapo populations formed a second cluster, and two additional This is an Accepted Manuscript of an article published in Flora Morphology, Distribution, Functional Ecology of Plants on 9 May 2014, available online: http://dx.doi. org/10.1016/j.flora. 2014.03. 011
A Molecular Mechanism for Circadian Clock Negative Feedback

New cogs in the mammalian circadian clock are identified. Circadian rhythms in mammals are generated by a feedback loop in which the three PERIOD (PER) proteins, acting in a large complex, inhibit the transcriptional activity of the CLOCK-BMAL1 dimer, which represses their own expression. Although fundamental, the mechanism of negative feedback in the mammalian clock, or any eukaryotic clock, is unknown. We analyzed protein constituents of PER complexes purified from mouse tissues and identified PSF (polypyrimidine tract–binding protein–associated splicing factor). Our analysis indicates that PSF within the PER complex recruits SIN3A, a scaffold for assembly of transcriptional inhibitory complexes and that the PER complex thereby rhythmically delivers histone deacetylases to the Per1 promoter, which repress Per1 transcription. These findings provide a function for the PER complex and a molecular mechanism for circadian clock negative feedback.
The acoustic repertoire of wild common bottlenose dolphins ( Tursiops truncatus ) in Walvis Bay , Namibia

Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Private Bag X20, Hatfield 0028, Gauteng, South Africa; Namibian Dolphin Project, PO Box 5209, Walvis Bay, Erongo, Namibia; Sapienza Università di Roma, Dipartimento di Scienze della Terra, Piazzale Aldo Moro 5, 00185 Rome, Italy; Centre Scientifique de Monaco (CSM), Départment de Biologie Polaire, LIA-647 BioSensib (CSM-CNRS-UdS), 8 Quai Antione Ier, 98000 Monaco
A phase I dose escalation and expansion study of the next generation oral SERD AZD9833 in women with ER-positive, HER2-negative advanced breast cancer.

1024 Background: AZD9833 is an oral selective estrogen receptor (ER) antagonist and degrader (SERD) that has shown antitumor efficacy in a range of preclinical models of breast cancer. Methods: SERENA-1 (NCT03616587) is an ongoing Phase 1, open-label study in pre- and post-menopausal women, after ≥1 endocrine therapy and ≤2 prior chemotherapies for ER+ HER2- advanced breast cancer (ABC). The primary objective is to determine the safety and tolerability of AZD9833 once daily (QD), with dose-limiting toxicities (DLTs) in 28d defining the maximum tolerated dose. Secondary objectives include pharmacokinetics and anti-tumor response. Pharmacodynamic (PD) analysis includes ER modulation in paired tumor biopsies and ctDNA dynamic changes. Results: At 20 January 2020: 60 patients were treated (median prior therapies 5 (1–9); prior fulvestrant (Fv) 82%; prior CDK4/6i 68%) across five doses; 25 mg QD n=12, 75 mg QD n=12, 150 mg QD n=13, 300 mg QD n=13, 450 mg QD n=10. AZD9833 exposure was dose proportional after multiple doses, with a median terminal t1/2 of 12h. Treatment-related AEs experienced by ≥10% of patients were visual disturbances (53%; 91% G1, 6% G2, 3% G3), bradycardia/sinus bradycardia (45%; 93% G1, 7% G2), nausea (18%; 46% G1, 55% G2), fatigue (13%; 38% G1, 63% G2), dizziness (10%; 83% G1, 17% G3) vomiting (10%; 50% G1, 33% G2, 17% G3), and asthenia (10%; 67% G1, 33% G2). Three patients experienced DLTs: G3 QTcF prolongation (300 mg); G3 vomiting (450 mg); and a combination of G2 visual disturbance, G2 headache and G2 gait disturbance (450 mg). DLTs resolved with dose reduction. No G4 or 5 AEs were reported. Efficacy data are presented in the table below; objective response rate (ORR) and clinical benefit rate (CBR) at 24 weeks. Clinical trial information: NCT03616587 . ER signalling pathway modulation was observed in all dose cohorts. In patients where clinical responses occurred and paired biopsies obtained, 98% reduction in Ki67 was measured. Updated data will be presented. Conclusions: AZD9833 has an encouraging efficacy and dose-dependent safety profile. Evidence of clinical benefit and target engagement was observed at all dose levels in women with ER+ ABC, including patients pre-treated with CDK4/6i and Fv, and those with ESR1 mutations. A Phase 2 study comparing efficacy and safety of three doses AZD9833 vs Fv is planned (NCT04214288). [Table: see text]
Adult ovarian granulosa cell tumor: Role of systemic chemotherapy and surgical treatment.

e18083 Background: Granulosa cell tumor (GCT) are rare sex cord-stromal tumours. Their frequency is approximately 3% - 5% of all malignant ovarian tumors, and the incidence is from 0.6 to 2.1 cases per 100 000 women per year. According to the histological features, GCT are divided into two types: adult and juvenile. In the 2014 WHO histological classification, GCT were divided into borderline, which included the GCT of the juvenile type, and the malignant GCT of the adult type (AGCT). Despite the definition of AGCT not as borderline, but as low-grade malignant tumors, there are no specific recommendations for the surgical and drug treatment in such patients. Main method of treatment is surgical. Role of systemic treatment due to rarity of AGCT and late recurrence still has not determined. Methods: Data of 93 patients in our institution who were diagnosed with AGCT I-IV stage of the disease between 1980 and 2017 were evaluated. The data were obtained from the files of the patients, electronic database of the gynecologic oncology clinic, operation notes, and pathology records. Results: Stage of the disease, the spread of the tumor beyond the capsule and the number of mitoses of more than 10 significantly influenced the OS rates (p < 0.05). The average time before the onset of the first relapse in IA, IB stage was 134.5 months, in IC stage - 67.4 months, in II-IV stage - 34.3 months. Stage of the disease is an independent prognostic factor for the occurrence of a relapse of the disease. In stage I disease there was no influence of the volume of surgical treatment and adjuvant chemotherapy on DFS and the duration of disease-free period (p > 0.05). The duration of the non-progressive period was some, but not significantly more when performing optimal cytoreduction for the recurrence of the disease, and did not depend on the implementation regimen and adjuvant chemotherapy. Conclusions: There were not found significant difference in the overall and relapse-free survival of patients with ovarian AGCT, depending on the options of surgical and drug treatment they underwent. Studies showed that hormones play a critical role in the pathogenesis and treatment of GCT, especially in some ineffective cases for radiotherapy and chemotherapy. Additional multicenter randomized trials are needed to clarify the effectiveness of the various options for surgical and drug treatment of adult GCT patients.
High-dimensional Hawkes processes for limit order books: modelling, empirical analysis and numerical calibration

High-dimensional Hawkes processes with exponential kernels are used to describe limit order books in order-driven financial markets. The dependencies between orders of various types are carefully studied and modelled, based on a thorough empirical analysis. The observation of inhibition effects is particularly interesting, and leads us to the use of non-linear Hawkes processes. Specific attention is devoted to the calibration problem, in order to account for the high dimensionality of the problem and the very poor convexity properties of the MLE. Our analyses show a good agreement between the statistical properties of order book data and those of the model.
Hepatitis B, C and Delta Viruses’ Infections and Correlate Factors Among Female Sex Workers in Burkina Faso, West-Africa

Female Sex Workers (FSW) have increased vulnerability to viral hepatitis B, C and D transmission. Our study aimed to assess the seroprevalence of hepatitis B, C and D viruses and their associated factors among FSW in Ouagadougou, Burkina Faso.This is a cross-sectional study among FSW at least 18 years old in Ouagadougou, Burkina Faso. Data were collected from February 2013 to May 2013 using Respondent-Driven Sampling (RDS). Hepatitis B, C, and D tests were performed on FSW storage serums using fourth generation ELISA kits. Survey-weighted bivariate and multivariate logistic regression analyses were performed using Stata version 14 to identify factors associated with viral hepatitis infections.Population-weighted prevalence of viral hepatitis infections in FSW was respectively 18.2% (95%CI: 14.4-22.9) for Hepatitis B Virus (HBV), 10.6% (95%CI: 07.5-14.8) for Hepatitis C Virus (HCV) and 1.5% (95Cl: 0.2-10.3) for Hepatitis D Virus (HDV). Factors independently associated with HCV include positive HIV status, inconsistent condom use during the last 12 months, condom reuse with clients, sex with clients in the street, bars or public gardens. No sociodemographic or behavioral factors were independently associated with HBV infection.The prevalence of HBV and HCV was high among FSW and the prevalence of HDV was relatively low in this group in Burkina Faso. These findings suggest urgent and comprehensive prevention of these viruses through education for safer sex and behaviors, and immunization against HBV for FSW.