Miracle-dz/UniFAR-FTUs huggingface dataset:
Thermal Processes Using Attosecond Laser Pulses: When Time Matters

Introduction. - Wave phenomena: an overview. - Causal thermal phenomena, classical description. - Causal thermal phenomena, quantal description. - Application of the quantum heat transport equation. - Causal thermal phenomena in a Planck Era. - Attophysics and technology with ultra-short laser pulses. - Faster, brighter, shorter. - Fundamental physics with attosecond laser pulses. - Epilogue. The emergence of quantum dynamics in a classical world. - Appendices.
Measurement of thermal properties of biological tissues and tissue-mimicking phantom with a dual-needle sensor

This work presents the measurement of the thermal properties of ex vivo biological tissues (i.e., porcine liver and kidney tissues) as a function of temperature, along with the thermal characterization of a tissue-mimicking agar-based phantom. The evaluation of the thermal properties was performed by the dual needle technique, adopting a sensor equipped with two needles, capable to deliver thermal energy to the biomaterial and monitor the related tissue thermal behavior. Measurements of thermal conductivity, thermal diffusivity, and volumetric heat capacity were conducted at room temperature and at temperatures relevant from a biological point of view, namely, body temperature and temperatures of $\boldsymbol{\sim 60\ ^{\circ}\mathrm{C}-65\ ^{\circ}\mathrm{C}}$, which are typically correlated to instantaneous thermal damage in tissue. Thermal properties of biological tissue remained rather constant at the investigated temperatures: average values of thermal conductivity ranged from 0.515 W/(m·K) to 0.575 W/(m·K), thermal diffusivity ranged from 0.144 mm2/s to 0.163 mm2/s, whilst the average volumetric heat capacity was from 3.48 MJ/(m3·K) to 3.72 MJ/(m3·K). Furthermore, the thermal properties of the realized agar phantom were comparable to the ones of biological tissues. The results of this study provide valuable information for the characterization of porcine liver and kidney tissues, in terms of their thermal properties, to be used in predictive mathematical models of thermal therapies and validate the usage of agar phantoms as tissue-mimicking materials.
STEAP1–4 (Six-Transmembrane Epithelial Antigen of the Prostate 1–4) and Their Clinical Implications for Prostate Cancer

Simple Summary Despite recent therapeutic advances in the treatment of prostate cancer, metastatic castration-resistant prostate cancer continues to cause significant morbidity and mortality. New research into highly expressed proteins in metastatic castration-resistant prostate cancer shows that Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) are significant drivers of prostate cancer aggressiveness and metastasis. STEAP1, in particular, is highly expressed on the plasma membrane of prostate cancer cells and has received significant attention as a potential therapeutic target. This review highlights what is known about STEAP1–4 and identifies knowledge gaps that require further research. Abstract Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. Thus far, five homologs are known: STEAP1, STEAP1B, STEAP2, STEAP3, and STEAP4. In prostate cancer, STEAP1, STEAP2, and STEAP4 are overexpressed, while STEAP3 expression is downregulated. Although the metalloreductase activities of STEAP1–4 are well documented, their other biological functions are not. Furthermore, the properties and expression levels of STEAP heterotrimers, homotrimers, heterodimers, and homodimers are not well understood. Nevertheless, studies over the last few decades have provided sufficient impetus to investigate STEAP1–4 as potential biomarkers and therapeutic targets for prostate cancer. In particular, STEAP1 is the target of many emerging immunotherapies. Herein, we give an overview of the structure, physiology, and pathophysiology of STEAP1–4 to provide context for past and current efforts to translate STEAP1–4 into the clinic.
The complete chloroplast genome sequence of Ficus pandurata Hance var. angustifolia W.C. Cheng (Moraceae)

Abstract Ficus pandurata var. angustifolia is an edible plant popular throughout China where it has a long history of use in traditional She medicine. Using Illumina sequencing, we assembled and annotated the complete chloroplast (cp) genome of F. pandurata var. angustifolia which is 160,526 bp and encodes 130 genes, comprised of 85 protein-coding genes, 37 transfer RNA (tRNA) genes, and eight ribosomal RNA (rRNA) genes. Phylogenetic analysis resolved F. pandurata var. angustifolia as sister to F. deltoidea which together formed a clade with F. heteromorpha. This complete cp genome sequences is a valuable resource for future studies of evolution and species delimitation in genus Ficus as well as variety breeding and conservation for this species.
Assessment of Hygiene Behavior and Associated Factors Among School Children in Shey Bench, Southwest, Ethiopia. An Institutional Based-Cross Sectional Study

In underdeveloped countries, such as Ethiopia, the impact of disease burden caused by inadequate, contaminated water and a lack of sanitation is a huge burden. Water and sanitation-related infections are still a high-risk habit among primary school-aged children. As a reason, the objective was to analyze hygiene behavior and associated factors among school children in Shey Bench, Southwest Ethiopia, during the 2018/19 school year. An institutional-based descriptive cross-sectional study was done in 2019 to collect data from 770 primary school students in grades 5th through 8th from January 1 to 30, 2019. Data were entered into Epi data 4.2 and then analyzed in SPSS V. 21.0. Multivariate logistic regression analysis was used to identify independent factors of hygienic behavior. In this study area, 34.1 percent of school students have good hygiene behavior. Being female students (AOR=2.68), Urban residency (AOR=1.86), having poor hand-washing knowledge (AOR=0.148), lack of availability of hand-washing facility (AOR=0.541), separate toilet for male and female (AOR=2.11), no read and write father's educational status (AOR=0.314) and presence of clubs in the school (AOR=1.75) were all significantly associated with hygienic behavior In general, there is a poor hygiene. Urban residency, no read and write father's educational status, existence of sanitation club in schools, having separate toilets for boys and girls, having hand washing available in the facility, and having poor knowledge of hand washing were all substantially associated to hygienic behavior.
Quantum Key Distribution: Modeling and Simulation through BB84 Protocol Using Python3

Autonomous “Things” is becoming the future trend as the role, and responsibility of IoT keep diversifying. Its applicability and deployment need to re-stand technological advancement. The versatile security interaction between IoTs in human-to-machine and machine-to-machine must also endure mathematical and computational cryptographic attack intricacies. Quantum cryptography uses the laws of quantum mechanics to generate a secure key by manipulating light properties for secure end-to-end communication. We present a proof-of-principle via a communication architecture model and implementation to simulate these laws of nature. The model relies on the BB84 quantum key distribution (QKD) protocol with two scenarios, without and with the presence of an eavesdropper via the interception-resend attack model from a theoretical, methodological, and practical perspective. The proposed simulation initiates communication over a quantum channel for polarized photon transmission after a pre-agreed configuration over a Classic Channel with parameters. Simulation implementation results confirm that the presence of an eavesdropper is detectable during key generation due to Heisenberg’s uncertainty and no-cloning principles. An eavesdropper has a 0.5 probability of guessing transmission qubit and 0.25 for the polarization state. During simulation re-iterations, a base-mismatch process discarded about 50 percent of the total initial key bits with an Error threshold of 0.11 percent.
Differential Radiomodulating Action of Olea europaea L. cv. Caiazzana Leaf Extract on Human Normal and Cancer Cells: A Joint Chemical and Radiobiological Approach

The identification of a natural compound with selectively differential radiomodulating activity would arguably represent a valuable asset in the striving quest for widening the therapeutic window in cancer radiotherapy (RT). To this end, we fully characterized the chemical profile of olive tree leaf polyphenols from the Caiazzana cultivar (OLC), autochthonous to the Campania region (Italy), by ultra-high-performance liquid chromatography–high-resolution mass spectrometry (UHPLC-HR-MS). Oleacein was the most abundant molecule in the OLC. Two normal and two cancer cells lines were X-ray-irradiated following 24-h treatment with the same concentration of the obtained crude extract and were assessed for their radioresponse in terms of micronucleus (MN) induction and, for one of the normal cell lines, of premature senescence (PS). Irradiation of pre-treated normal cells in the presence of the OLC reduced the frequency of radiation-induced MN and the onset of PS. Conversely, the genotoxic action of ionising radiation was exacerbated in cancer cells under the same experimental conditions. To our knowledge, this is the first report on the dual action of a polyphenol-rich olive leaf extract on radiation-induced damage. If further confirmed, these findings may be pre-clinically relevant and point to a substance that may potentially counteract cancer radioresistance while reducing RT-associated normal tissue toxicity.
A continuous terminal sliding mode algorithm for robot manipulators: an application to force control

The problem of hybrid position/force control on rigid surfaces with high friction effects is considered in this letter. The controller is based on a Continuous Terminal Sliding Mode Algorithm (CTSMA), which allows to obtain a high tracking performance for industrial robot manipulators with DC motors. When the desired trajectory corresponds to the geometric constraint of a rigid surface, then an additional PI term can be included in the control law to achieve force tracking perpendicular to the surface, while friction effects are rejected by the CTSMA, thus leading to a notorious performance improvement. To the best of the authors' knowledge this is the first time that this technique is used for this particular goal. In case the robot manipulator does not own DC motors as actuators, the algorithm can be complemented with the knowledge of the inertia matrix to make the result applicable to any kind of rigid robots. Both simulation and experimental results are presented and the outcomes are compared with a GPI control/observer approach. The Root Mean Square Errors (RMSE) are computed to show objectively the advantages of the proposed solution.
What is the true dropped calls rate when in the test it was found to be zero

We study the distributions of dropped calls rates for different wireless (cellular) carriers in different markets. Our statistics comprises over 700 different market/carrier combinations. We find that the dropped calls rates distribution is very close to lognormal. We derive an equation for the most probable dropped calls rate for particular carrier in particular market, which depends on the number of dropped calls observed, total number of calls and the parameters of the lognormal distribution. We apply this analysis to blocked and "no service" calls as well.
Physical Performance Tests in Adult Neck Pain Patients with and without Clinical Myelopathic Signs: A Matched Case-Control Study

Patients with neck pain may experience cervical myelopathy, this may be detected by clinical myelopathic signs, although they did not have any symptom of myelopathy, except having neck pain. Decreasing physical performance is one symptom of cervical myelopathy that can lead to reduced quality of life in the elderly, however, in adult neck pain with clinical myelopathic signs have not been evaluated. Therefore, this research aimed to compare physical performance in two groups of adult patients with neck pain: those with and without clinical myelopathic signs. A total of 52 participants, gender, age, and body mass index (BMI) matched were allocated into 2 groups of 26 subjects with neck pain, those with, and without, clinical myelopathic signs. The grip and release test, nine-hole peg test, ten second step test and foot-tapping test were evaluated. The group of neck pain participants with clinical myelopathic signs exhibited greater impairment in all the tests than the group without clinical myelopathic signs (p < 0.001). Effect sizes (Cohen’s d) were grip and release test: 2.031, nine-hole peg test: 1.143, ten second step test: 1.329, and foot-tapping test: 0.798. Neck pain participants with clinical myelopathic signs demonstrated reduced physical performance. Physical performance tests may need to assessed in adult patients with neck pain who had clinical myelopathic signs.
Causal Model Analysis of Police Officers’ COVID-19 Fear, Resistance to Organizational Change Effect on Emotional Exhaustion and Insomnia

Since the end of 2019, COVID-19 has continued to spread around the world. The police have performed various epidemic prevention and routine duties. This study explores how police officers’ COVID-19 fear, resistance to organizational change, intolerance of uncertainty, and secondary trauma affect emotional exhaustion and insomnia in the context of COVID-19. A total of 205 valid police samples were collected in this study, and the established hypotheses were tested using confirmatory factor analysis and structural equation modeling. The results of the study confirmed that during the COVID-19 outbreak, secondary trauma of police officers positively affects emotional exhaustion and insomnia; intolerance of uncertainty positively affects emotional exhaustion; resistance to organizational change positively affects intolerance of uncertainty and emotional exhaustion; intolerance of uncertainty mediates the relationship between resistance to organizational change and emotional exhaustion; COVID-19 fear positively influences secondary trauma.
The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging

Abstract Sarcopenia is an age-related systemic disease characterized by skeletal muscle aging that generally severely affects the quality of life of elderly patients. Metabolomics analysis is a powerful tool for qualitatively and quantitatively characterizing the small molecule metabolomics of various biological matrices in order to clarify all key scientific problems concerning cell metabolism. The discovery of optimal therapy requires a thorough understanding of the cellular metabolic mechanism of skeletal muscle aging. In this review, the relationship between skeletal muscle mitochondria, amino acid, vitamin, lipid, adipokines, intestinal microbiota and vascular microenvironment has been separately reviewed from the perspective of metabolomics, and a new therapeutic direction has been suggested.
Next Steps for Immunotherapy in Glioblastoma

Simple Summary Prognosis for glioblastoma patients remains poor despite the current standard of care treatments. More recent investigations have focused on immunotherapy, which utilizes a patient’s immune system to target cancer cells. Though proven to be successful in non-central nervous system cancers, immunotherapies have yielded disappointing results for glioblastoma thus far. A variety of factors play into the efficacy of immunotherapy for glioblastoma and have become new areas of interest. Here we review both historical and emerging immunotherapeutic approaches, as well as the molecular factors that have been shown to impact the efficacy of immunotherapies. Abstract Outcomes for glioblastoma (GBM) patients undergoing standard of care treatment remain poor. Here we discuss the portfolio of previously investigated immunotherapies for glioblastoma, including vaccine therapy and checkpoint inhibitors, as well as novel emerging therapeutic approaches. In addition, we explore the factors that potentially influence response to immunotherapy, which should be considered in future research aimed at improving immunotherapy efficacy.
Moisture and Seasonality Shifts Recorded in Holocene and Pleistocene Speleothems From Southeastern Arabia

The source and seasonality of rainfall in southern Arabia during the early‐ to mid‐Holocene and preceding humid periods are controversial because fossil lacustrine sediments provide solely indirect information on the amount of rainfall. Hydrogen and oxygen isotope measurements on fluid inclusion water trapped in Holocene and Pleistocene stalagmites from Hoti Cave in Northern Oman are direct indicators of the isotopic composition of paleoprecipitation. Isotope values of fluid inclusions formed during peak interglacial periods plot along monsoonal water lines and are indicative of a southern monsoonal moisture source. The last monsoon‐dominated period lasting from ∼10,100 to 6,300 years before present was terminated within a few decades in southeastern Arabia. The subsequent reduction in rainfall amount and change from predominantly summer to predominantly winter rainfall had a profound impact on human communities living in this area and triggered migration from inland to coastal areas where resources were more abundant.
First Simultaneous Lidar Observations of Thermosphere‐Ionosphere Sporadic Ni and Na (TISNi and TISNa) Layers (∼105–120 km) Over Beijing (40.42°N, 116.02°E)

We report the first simultaneous lidar observations of thermosphere‐ionosphere sporadic nickel and Na (TISNi and TISNa) layers in altitudes ∼105–120 km over Yanqing (40.42°N, 116.02°E), Beijing. From two years of data spanning April 2019 to April 2020 and July 2020 to June 2021, TISNi layers in May and June possess high densities with a maximum of 818 cm−3 on 17 May 2021, exceeding the density of main layer peak (∼85 km) by ∼4 times. They correlate with strong sporadic E layers observed nearby. TISNa layers occur at similar altitudes as TISNi with spatial‐temporal correlation coefficients of ∼1. The enrichment of Ni in TISNi is evident as the [TISNi]/[TISNa] column abundance ratios are ∼1, about 10 times the main layer [Ni]/[Na] ratios. These results are largely explained by neutralization of converged Ni+ and Na+ ions via recombination with electrons. Calculations show direct recombination dominating over dissociative recombination above ∼105 km.
A 30 GHz 8-Bit Phased Array Transmitter for Satellite Communication in 22nm FDSOI

This work presents a fully integrated transmitter (TX) front-end for satellite communication in the Ka-band. The TX employs radio frequency (RF) phase shifting for beamforming. Phase shifting is achieved through a vector modulator, the vector modulator is followed by a variable output power switching driver stage to form an integrated TX front-end. The TX achieves a 360° phase shifting range with a resolution of 1.4° (8-bit) and a maximum saturated output power (Psat) of 21 dBm while achieving a system efficiency of 38.5%. A simple efficient power control technique is proposed, and several layout optimization techniques were used to achieve such high phase shifting resolution. To the best of the authors’ knowledge, this is one of the highest reported resolutions at this frequency range. The transmitter operates from 27.5 GHz to 31.5 GHz and is implemented in 22nm FDSOI technology with 1. SV supply.
Motor Neuroplastic Effects of a Novel Paired Stimulation Technology in an Incomplete Spinal Cord Injury Animal Model

Paired stimulation of the brain and spinal cord can remodel the central nervous tissue circuitry in an animal model to induce motor neuroplasticity. The effects of simultaneous stimulation vary according to the extent and severity of spinal cord injury. Therefore, our study aimed to determine the significant effects on an incomplete SCI rat brain and spinal cord through 3 min and 20 min stimulations after 4 weeks of intervention. Thirty-three Sprague Dawley rats were classified into six groups: (1) normal, (2) sham, (3) iTBS/tsDCS, (4) iTBS/ts-iTBS, (5) rTMS/tsDCS, and (6) rTMS/ts-iTBS. Paired stimulation of the brain cortex and spinal cord thoracic (T10) level was applied simultaneously for 3–20 min. The motor evoked potential (MEP) and Basso, Beattie, and Bresnahan (BBB) scores were recorded after every week of intervention for four weeks along with wheel training for 20 min. Three-minute stimulation with the iTBS/tsDCS intervention induced a significant (p < 0.050 *) increase in MEP after week 2 and week 4 treatments, while 3 min iTBS/ts-iTBS significantly improved MEP (p < 0.050 *) only after the week 3 intervention. The 20 min rTMS/ts-iTBS intervention showed a significant change only in post_5 min after week 4. The BBB score also changed significantly in all groups except for the 20 min rTMS/tsDCS intervention. iTBS/tsDCS and rTMS/ts-iTBS interventions induce neuroplasticity in an incomplete SCI animal model by significantly changing electrophysiological (MEP) and locomotion (BBB) outcomes.
Antimicrobial, anticancer, and antioxidant potential of two dominant macro-lichen Dirinaria aegialita and Parmotrema praesorediosum collected from Similipal Biosphere Reserve of Odisha, India

The present study was undertaken to evaluate the antimicrobial, antioxidant, and anticancer activity of Dirinaria aegialita (Afzel. ex Ach.) B.J. Moore and Parmotrema praesorediosum (Nyl.) Hale, the two dominant macrolichens taxa from the Similipal Biosphere Reserve of Odisha. Both the lichens were evaluated for their efficacy against three bacterial species such as Staphylococcus aureus, Pseudomonas aeruginosa , and Bacillus subtilis, and three fungal species such as Aspergillus niger , Trichoderma harzianum , and Candida albicans . The D . aegialita and P . praesorediosum showed higher inhibitory effect against Bacillus subtilis and Staphylococcus aureus , respectively. D . aegialita also showed the higher inhibitory activity against MCF-7 and MDA MB-231 breast cancer cell line as compared to P . praesorediosum . Besides, D . aegialita was found to have better antioxidant activity than P . praesorediosum in scavenging assay. Thus, the results of the above study confirmed that D . aegialita species is having better potential in its antibacterial, antioxidant, and anticancer activity as compared to P . praesorediosum .
How Hard Is It to Detect Surveillance? A Formal Study of Panopticons and Their Detectability Problem

The Panopticon (which means “watcher of everything”) is a well-known prison structure of continuous surveillance and discipline studied by Bentham in 1785. Today, where persistent, massive scale, surveillance is immensely facilitated by new technologies, the term Panopticon vaguely characterizes institutions with a power to acquire and process, undetectably, personal information. In this paper we propose a theoretical framework for studying Panopticons and their detectability status. We show, based on the Theory of Computation, that detecting Panopticons, modelled either as a simple Turing Machine or as an Oracle Turing Machine, is an undecidable problem. Furthermore, we show that for each sufficiently expressive formal system, we can effectively construct a Turing Machine for which it is impossible to prove, within the formal system, its Panopticon status. Finally, we discuss how Panopticons can be physically detected by the heat they dissipate each time they acquire, effortlessly, information in the form of an oracle and we investigate their detectability status with respect to a more powerful computational model than classical Turing Machines, the Infinite Time Turing Machines (ITTMs).