Miracle-dz/UniFAR-FTUs huggingface dataset:
Global analysis insights into coupling relationship between lignan and lignin metabolism of �ax

Background: Flax ( Linum usitatissimum L.) is one of the most important economic crops in the world. The lignin content of �ax stems directly determines the quality of �ax �bers. Flax seeds contain lignans of highly bene�cial for human health. Results: To elucidate the metabolic relationship between these compounds and the regulatory nodes of their metabolic processes, third generation (PacBio Iso-Seq) and second generation (Illumina) sequencing technologies were used to sequence the transcriptomes of a pair of �ax cultivars with signi�cant differences in lignan content. It was discovered that the differential expressed genes (DEGs) are signi�cantly enriched in the lignin and lignan biosynthesis pathways. Furthermore, there are seven genes with signi�cant differences in expression that were annotated as UDP-glucosyl transferases ( UGTs ). We found that lignan and lignin content is signi�cantly negatively correlated with each other. SEM observations on �ax bast �bers provided further evidence of this relationship. Conclusions: This is the �rst full-length transcriptome analysis on �ax plants using third-generation sequencing technologies, and it is also the �rst study to observe a negative correlation between lignin and lignan content of �ax plants. Furthermore, it was found that UGTs are likely to be regulatory node genes for lignan and lignin metabolism.
Guideline for infection control in health care personnel , 1998

I. Infection control issues for health care personnel: An overview A. EXECUTIVE SUMMARY 291 B. INTRODUCTION 292 C. INFECTION CONTROL OBJECTIVES FOR A PERSONNEL HEALTH SERVICE 292 D. ELEMENTS OF A PERSONNEL HEALTH SERVICE FOR INFECTION CONTROL 293 1. Coordination with other departments 293 2. Medical evaluations 293 3. Personnel health and safety education 293 4. Immunization programs 296 5. Management of job-related illnesses and exposures 298 6. Health counseling 301 7. Maintenance of records, data management, and confidentiality 301 E. EPIDEMIOLOGY AND CONTROL OF SELECTED INFECTIONS TRANSMITTED AMONG HEALTH CARE PERSONNEL AND PATIENTS 302 1. Bloodborne pathogens 302
Rapid Differential Detection of H1 and H3 Subtype Swine In uenza Viruses by a TaqMan-MGB Based Duplex One-Step Real Time RT-PCR Assay

Kaibiao Chen Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Ming Kong Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Jiao Liu Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Jun Jiao Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Zixiong Zeng Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou Unversity Liwei Shi Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Xinxin Bu Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Yayao Yan Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Yu Chen Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Ruyi Gao Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou Univerisity Xiaowen Liu Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Xiaoquan Wang Animal Infectious Diseases Laboratory, College of Veterinary Medicine,Yangzhou University Jiao Hu Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Shunlin Hu Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Xinan Jiao Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Xiufan Liu Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University Min Gu (  gumin@yzu.edu.cn ) Animal Infectious Diseases Laboratory, College of Veterinary Medicine, Yangzhou University. https://orcid.org/0000-00024670-9109
Social Relationships: the Secret Ingredient of Synergistic Venture Cooperation

Social relationships play an important role in organizational entrepreneurship. They are crucial to entrepreneurs' decisions because, despite the bleeding-edge technological advancements observed nowadays, entrepreneurs as human beings will always strive to be social. During the COVID-19 pandemic many companies moved activities into the virtual world and as a result offline Social relationships became rarer, but as it turns out, even more valuable, likewise, the inter-organizational cooperation enabling many companies to survive. This chapter aims to develop knowledge about entrepreneurs' SR and their links with inter-organizational cooperation. The results of an integrative systematic literature review show that the concept of Social relationships, although often investigated, lacks a clear definition, conceptualization, and operationalization. This chapter revealed a great diversity of definitions for Social relationships, including different scopes of meaning and levels of analysis. The authors identify 10 building blocks and nine sources of entrepreneurs' Social relationships. The authors offer an original typology of Social relationships using 12 criteria. Interestingly, with regard to building blocks, besides those frequently considered such as trust, reciprocity and commitment, the authors also point to others more rarely and narrowly discussed, such as gratitude, satisfaction and affection. Similarly, the authors discuss the varied scope of sources, including workplace, family/friendship, past relationships, and ethnic or religious bonds. The findings of this study point to a variety of links between Social relationships and inter-organizational cooperation, including their positive and negative influences on one another. These links appear to be extremely dynamic, bi-directional and highly complex. © Katarzyna Czernek-Marszalek, Patrycja Klimas, Patrycja Juszczyk and Dagmara Wójcik Published by Emerald Publishing Limited.
EGFR gene-mutation status correlated with therapeutic decision making in lung adenocarcinoma

: The purpose of this study was to investigate the correlation between EGFR -mutation status and treatment efficacy for advanced lung adenocarcinoma patients. A total of 47 patients receiving erlotinib as first-line therapy were divided into two groups: the EGFR gene mutation group included 19 patients with known EGFR-sensitive mutations, and the EGFR -mutation status-unknown group comprised 28 patients with unknown EGFR -mutation status. Both objective response rate and disease-control rate were significantly higher in the EGFR -mutation group compared with the EGFR -unknown group (42.1% vs 14.2%, P = 0.032; 94.7% vs 57.1%, P = 0.005). Age, sex, smoking history, stage of disease, and tissue-sample source were not significantly correlated with the distributions of mutation status. In conclusion, it is important for advanced lung adenocarcinoma patients to undergo gene analysis before being assigned a molecularly targeted drug as first-line treatment.
An evidence-based review of unoprostone isopropyl ophthalmic solution 0.15% for glaucoma: place in therapy

: Glaucoma is a progressive, neurodegenerative optic nerve disease that can cause significant visual morbidity and affects over 60 million people worldwide. The only known modifiable risk factor for glaucoma at this time is elevated intraocular pressure (IOP), which may be treated with medications, laser therapy, and/or incisional surgery. Topical ocular medications are commonly used as first-line therapy for glaucoma, although side effects may limit their use. Unoprostone is a novel 22-carbon ocular hypotensive agent that may be advantageous in treating some patients with open angle glaucoma or ocular hypertension. Unlike the 20-carbon prostanoids, such as latanoprost, that lower IOP primarily through an increase in uveoscleral outflow, unoprostone may lower IOP through increased aqueous outflow via the conventional trabecular meshwork pathway. Although not as efficacious as other prostanoids, unoprostone is effective for IOP reduction both as monotherapy and adjunctive therapy with timolol. Unoprostone has decreased affinity for the prostaglandin F2 α receptor, which may explain its well tolerated ocular and systemic side effect profile compared with other prostanoids.
Investigating the Mechanical and Microstructural Characteristics of Clayey-Sand Reinforced with Geopolymer Incorporating Copper Slag

This study aimed to explore the effects of stabilizing clayey-sand with mineral geopolymers, focusing on the mechanical and microstructural behavior of the treated soil. Experimental tests, including Atterberg limits (PI), pH analysis, standard proctor compaction, uncon�ned compressive strength (UCS), and ultrasonic P-wave velocity measurements, were conducted at different curing durations (2, 7, 14, and 28 days) under ambient temperature conditions (23 ± 2°C and (cid:0)90% relative humidity). Additionally, scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) analyses were performed to investigate the microstructural effects on strength enhancement. The study employed various combinations of non-traditional binders (copper slag) with an alkaline activator solution (AAS). The AAS consisted of 70% Na 2 SiO 3 and 30% NaOH, while the weight ratio of copper slag to AAS was set at 1. Different molar concentrations of NaOH (0, 2, 4, 8, 11, and 15M) and varying percentages of copper slag (0, 10, and 15%) were selected. The results revealed three distinct behaviors exhibited by the samples. Notably, the strength increased with longer curing times for 8M and 11M concentrations, indicating a signi�cant strength gain. Numerical investigations also established a correlation between P-wave velocity and UC strength. Microstructural analysis identi�ed the sample with 11M NaOH and 15% copper slag as having the most compacted and dense structure.
Endogenous Technology Adoption and Medical Costs

Despite the claim that technology has been one of the most important drivers of healthcare spending growth over the past decades, technology variables are rarely introduced explicitly in cost equations. Furthermore, technology is often considered exogenous. Using 1996-2007 panel data on Swiss geographical areas, we assessed the impact of technology availability on per capita healthcare costs covered by basic health insurance while controlling for the endogeneity of health technology availability variables. Our results suggest that medical research, patent intensity and the density of employees working in the medical device industry are influential factors for the adoption of technology and can be used as instruments for technology availability variables in the cost equation. Our results are similar to previous findings: CT and PET scanner adoption is associated with increased healthcare costs while increased availability of PTCA facilities is associated with reductions in per capita spending. Nevertheless, our results suggest that the magnitude of these relationships is much greater in absolute value than that suggested by previous studies which did not control for the possible endogeneity of the availability of technologies.
Feasibility of totally extraperitoneal inguinal hernia repair in patients with previous prostatectomy.

Objectives Laparoscopic totally extraperitoneal inguinal hernia repair (TEP) surgery technique includes three key steps: reaching the preperitoneal space, reducing hernias, and placement of mesh. However, reaching the preperitoneal space can be complicated in patients with previous lower abdominal surgeries. This study aimed to assess the feasibility of laparoscopic inguinal TEP in patients with previous prostatectomies. Material and Methods Inguinal hernia patients who underwent laparoscopic TEP between January 2015 and February 2021 at Koç University Faculty of Medicine, Department of General Surgery, were included in this retrospective study. The operations were performed by five senior surgeons experienced in laparoscopy. Patients were divided into two study groups, as the radical prostatectomy (RP) group which included patients with previous prostatectomy non-RP which included patients without previous radical prostatectomy. Operative time (OT), length of hospital stay (LOS), and postoperative complications were compared within two groups. Results Three hundred and forty-nine patients underwent laparoscopic TEP, and 27 had previous prostatectomies. Among them, 190 patients had unilateral inguinal hernias, and 159 had bilateral inguinal hernias. Mean age of the patients in the non-RP and RP groups was 58.1 ± 14.7 and 73.9 ± 9.6 years, respectively. Only one (3.7%) case was complicated with urinary tract infection in the RP group, and 10 (3.1%) were complicated in the non-RP group. Complications for the non-RP group include hematomas in six cases, urinary tract infection in three cases, and urinary retention in one case. No significant difference in mean operative time was seen between non-RP and RP groups (p= 0.43). There was no significant difference in the means of the length of hospital stay between the two groups (p= 0.7). Conclusion Laparoscopic TEP in patients with a previous prostatectomy can be performed safely without prolonging the operative time and increasing the length of hospital stay.
A Survey on Applications of Small Uncrewed Aircraft Systems for Offshore Wind Farms

Offshore wind farms are attractive energy sources due to the abundancy of wind resources close to population centers. Nevertheless, offshore locations present unique challenges for atmospheric observation and turbine inspection which are essential for wind farm design and maintenance. Small uncrewed aircraft systems (sUAS) are well suited for solving many difficulties inherent to offshore sites. In the past decade, sUAS have risen as a versatile and cost-effective platform for a large variety of 5 scientific and commercial operations relating to atmospheric observation and infrastructure inspection. Most sUAS fall into one of two classes: fixed-wing or rotorcraft. Fixed-wing aircraft offer high endurance and range at the cost of constrained maneuverability. Rotorcraft are agile and user-friendly platforms, but offer limited endurance. We present a survey on the challenges and opportunities of utilizing fixed-wing and rotorcraft sUAS for wind resource assessment, operational observation, and inspection of offshore wind farms.
Emissions of nonmethane volatile organic compounds from open crop residue burning in the Yangtze River Delta region, China

Open crop residue burning is one of the major sources of air pollutants including the precursors of photooxidants like ozone and secondary organic aerosol. We made measurements of trace gases including nonmethane volatile organic compounds (NMVOCs) in a rural area in central East China in June 2010. During the campaign, we identified six biomass burning events in total through the simultaneous enhancement of carbon monoxide and acetonitrile. Four cases represented fresh plumes (<2 h after emission), and two cases represented aged plumes (>3 h after emission), as determined by photochemical age. While we were not able to quantify formic acid, we identified an enhancement of major oxygenated volatile organic compounds (OVOCs) as well as low molecular alkanes and alkenes, and aromatic hydrocarbons in these plumes. The observed normalized excess mixing ratios (NEMRs) of OVOCs and alkenes showed dependence on air mass age, even in fresh smoke plumes, supporting the view that these species are rapidly produced and destructed, respectively, during plume evolution. Based on the NEMR data in the fresh plumes, we calculated the emission factors (EFs) of individual NMVOC. The comparison to previous reports suggests that the EFs of formaldehyde and acetic acid have been overestimated, while those of alkenes have been underestimated. Finally, we suggest that open burning of wheat residue in China releases about 0.34 Tg NMVOCs annually. If we applied the same EFs to all crops, the annual NMVOC emissions would be 2.33 Tg. The EFs of speciated NMVOCs can be used to improve the existing inventories.
Geochronology and origin of Nanhongchong pluton in Shizishan ore-field, Anhui province

Nanhongchong pluton in Shizishan ore-field,Anhui province,is spatially close to those Yanshanian plutons that have metallogenic relations with important copper-iron-gold-sulfur deposits.Zircon U-Pb LA-ICPMS dating yields an age of 141.2±1.6Ma, which meets the ages of other plutons in the ore-field and suggests the magmatism event occurred between late Jurassic and early cretaceous.Nanhongchong pluton was metaluminous cale-alkaline granodiorite characterized by high alkali(Na_2OK_O). Rb,Ba, St,Th and U were enriched,while Nb,Ta and Ti were depleted.REE showed strong LREE enrichment with(La/Yb)_N ratios of 21.07～24.28 and the absence of Eu anomaly with δEu values of 0.92-1.03. Isotope geochemical study revealed initial ~(87)Sr/~(86)Sr ratios were 0.70792～0.70793 whilee_(Nd)(t)values were-9.5～9.1,and Nd model ages(1.67～1.71 Ga)were Mesoproterozoic. The characteristics above in accord with former relevant data indicate that the mixed magma derived from enriched mantle,intruded and fractionated in a crustal extension-thinning tectonic environment while assimilated a proportion of the crust.Particularly,the magma in Shizishan ore-field was rather evolved when Nanhongchong pluton formed and fractional crystallization was the dominant process then, which suggested moderately diverse magmatism.
Establishing the Callus-Based Isolation of Extracellular Vesicles from Cissus quadrangularis and Elucidating Their Role in Osteogenic Differentiation

Extracellular vesicles (EVs) are nano-sized vehicles secreted by all live cells to establish communication with adjacent cells. In recent years, mammalian EVs (MEVs) have been widely investigated for their therapeutic implications in human disease conditions. As the understanding of MEV composition and nature is advancing, scientists are constantly exploring alternatives for EV production with similar therapeutic potential. Plant-derived exosome-like nanovesicles (PDEVs) may be a better substitute for MEVs because of their widespread sources, cost-effectiveness, and ease of access. Cissus quadrangularis (CQ), known as “bone setter or Hadjod”, is a perennial plant utilized for its osteogenic potential. Its crude powder extract formulations are widely used as tablets and syrups. The present work elucidates the isolation of exosome-like nanovesicles (henceforth exosomes) from the culture supernatants of an in vitro cultured callus tissue derived from CQ. The physical and biological properties of the exosomes were successfully investigated using different characterization techniques. The therapeutic potential of the CQ exosomes was found to ameliorate the wound scratch injury and oxidative stress conditions in human-derived mesenchymal stem cells (hMSCs) and the pre-osteoblast (MC3T3) cell line. These exosomes also induced the proliferation and differentiation of hMSCs, as observed by alkaline phosphatase activity. These findings may serve as a proof of concept for further investigating the CQ exosomes as a nanocarrier for drug molecules in various therapeutic bone applications.
HUMAN CAPITAL STUDY: CAN ORGANIZATIONAL CITIZENSHIP BEHAVIOR FOR BOOSTING JOB SATISFACTION?

Organizational Citizenship Behavior (OCB) is a challenge in the world of work today, because organizations will certainly feel happy if they have employees who behave OCB. Organizations need to pay attention to employees and be able to manage employees so that they have superior employees that are not owned by other organizations. In this case it will also be beneficial for the organization. Problems that occur in organizations related to work ethics such as discipline. Therefore, it is necessary to build an OCB model that impacts Job Satisfaction in the workplace. In order to solve these organizational problems, it can facilitate the emergence of a work ethic. This research is a quantitative study, with a sample of 138 respondents from PT Pertamina Lubricants â€“ Production Unit Cilacap. Multiple linear regression analysis instruments and data processed using SPSS. The empirical test results prove that the dimensions of OCB including altruism, awareness, politeness, sportsmanship, and the virtues of citizenship have a significant effect on job satisfaction. The contribution of this study uses the perspective of human capital theory with managerial implicit which emphasizes the importance of building an adaptive work environment, building a better colletivism culture and increasing spirituality in the workplace.
Options for Understanding Regional Dynamics in Northern Australia

The Regional Dynamics Scoping Study reported here was carried out for the Tropical Savannas CRC in 2002-03. The project encompassed a substantial literature survey, a workshop of experts with knowledge of the north, several different exploratory model developments, and a collation of basic profiling data for savannas. Here we distil some of the lessons from all of these activities, recognising that their logic emerges from the details to be found by reading the whole report. We then propose elements of a potential research program for the CRC’s consideration.
Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition

Tightly regulated and highly adaptive lipid metabolic and transport pathways are critical to maintaining brain cellular lipid homeostasis and responding to lipid and inflammatory stress to preserve brain function and health. Deficits in the lipid handling genes APOE and GBA1 are the most significant genetic risk factors for Lewy body dementia and related dementia syndromes. Parkinson’s disease patients who carry both APOE4 and GBA1 variants have accelerated cognitive decline compared to single variant carriers. To investigate functional interactions between brain ApoE and GBA1, in vivo GBA1 inhibition was tested in WT versus ApoE-deficient mice. The experiments demonstrated glycolipid stress caused by GBA1 inhibition in WT mice induced ApoE expression in several brain regions associated with movement and dementia disorders. The absence of ApoE in ApoE-KO mice amplified complement C1q elevations, reactive microgliosis and astrocytosis after glycolipid stress. Mechanistically, GBA1 inhibition triggered increases in cell surface and intracellular lipid transporters ABCA1 and NPC1, respectively. Interestingly, the absence of NPC1 in mice also triggered elevations of brain ApoE levels. These new data show that brain ApoE, GBA1 and NPC1 functions are interconnected in vivo, and that the removal or reduction of ApoE would likely be detrimental to brain function. These results provide important insights into brain ApoE adaptive responses to increased lipid loads.