Miracle-dz/UniFAR-FTUs huggingface dataset:
A Systematic Review and Meta-Analysis of Interventions for Actinic Keratosis from Post-Marketing Surveillance Trials

Multiple interventions are available for the treatment of actinic keratosis (AK) showing high efficacy in pivotal trials. However, data from post-marketing surveillance studies have received little attention until now. Here, we systematically investigate interventions for AK from post-marketing surveillance trials as a proxy for real-world efficacy and tolerability. A systematic literature search was conducted in Medline, Embase, and CENTRAL. Pertinent trial registers were hand-searched until 25 March 2020. Results were pooled using a random-effects model to calculate pooled proportions and relative risks (RR) or were described qualitatively. Eleven records with a total sample size of n = 4109 were included. Three of the studies had an active-controlled design, while seven were single-armed. Participant complete clearance ranged from 23.1% for diclofenac sodium 3% gel to 88.9% for ingenol mebutate 0.05% gel. The lesion-specific clearance rate for photodynamic therapy (PDT) was 74% (95% confidence interval (CI) 56–87%). The recurrence rate was significantly higher for diclofenac sodium 3% in comparison to imiquimod 5% cream (RR 1.10, 95% CI 1.02–1.1.8) and ranged from 10.6% for ingenol mebutate 0.015% gel to 23.5% for PDT. Few patients discontinued the trials due to adverse events. The results from the majority of the post-marketing surveillance studies deviated from those of pivotal trials.
Glycine Betaine Accumulation, Significance and Interests for Heavy Metal Tolerance in Plants

Unexpected biomagnifications and bioaccumulation of heavy metals (HMs) in the surrounding environment has become a predicament for all living organisms together with plants. Excessive release of HMs from industrial discharge and other anthropogenic activities has threatened sustainable agricultural practices and limited the overall profitable yield of different plants species. Heavy metals at toxic levels interact with cellular molecules, leading towards the unnecessary generation of reactive oxygen species (ROS), restricting productivity and growth of the plants. The application of various osmoprotectants is a renowned approach to mitigate the harmful effects of HMs on plants. In this review, the effective role of glycine betaine (GB) in alleviation of HM stress is summarized. Glycine betaine is very important osmoregulator, and its level varies considerably among different plants. Application of GB on plants under HMs stress successfully improves growth, photosynthesis, antioxidant enzymes activities, nutrients uptake, and minimizes excessive heavy metal uptake and oxidative stress. Moreover, GB activates the adjustment of glutathione reductase (GR), ascorbic acid (AsA) and glutathione (GSH) contents in plants under HM stress. Excessive accumulation of GB through the utilization of a genetic engineering approach can successfully enhance tolerance against stress, which is considered an important feature that needs to be investigated in depth.
Solar Lake (Sinai). 5. The sulfur cycle of the bcnthic cyanobacterial mats1

The littoral sediments of Solar Lake (Sinai) consist of cyanobacterial mats up to 1 m thick. The vertical distributions in these mats of sulfur compounds, organic carbon, carbonate, and of sulfate-reducing and other anaerobic, heterotrophic bacteria are presented. The in situ rate of sulfate reduction measured with a radiotracer technique, decreased 10,000-fold from 5,400 Nmol SO/sub 4//sup 2 -//cm/sup 3//d at the surface to less than 1 at the bottom of the mats. Turnover rates of inorganic sulfur compounds and of organic matter were estimated. A high influx down into the cyanobactyerial mats of dissolved organic compounds produced by the epibenthic algae and bacteria could be deduced from the anaerobic respiration rates. A quantitative flow diagram of the sedimentary sulfur and carbon cycle is presented.
Using species abundance models as indicators of habitat disturbance in tropical forests

1. In temperate communities, species abundance distributions have been used to detect ecosystem disturbance: in undisturbed habitats, distributions are claimed to generally fit log-normal models, whereas in disturbed habitats, distributions fit log-series models. 2. There is a growing literature on the effects of habitat disturbance in tropical ecosystems and several studies suggest that species abundance models may be useful in detecting disturbance, although data are lacking. 3.Nummelin (1998) claims that these models are not universal indicators of forest disturbance, but we highlight a number of problems with the data presented in Nummelin's study and conclude that it is too soon to dismiss these models. We discuss several important points arising from Nummelin's study which need to be considered if species abundance models are to be used appropriately.
Thermodynamics of Adsorbed Methane Storage Systems Based on Peat-Derived Activated Carbons

Two activated carbons (ACs) were prepared from peat using thermochemical K2SO4 activation at 1053–1133 K for 1 h, and steam activation at 1173 K for 30 (AC-4) and 45 (AC-6) min. The steam activation duration affected the microporous structure and chemical composition of ACs, which are crucial for their adsorption performance in the methane storage technique. AC-6 displays a higher micropore volume (0.60 cm3/g), specific BET surface (1334 m2/g), and a lower fraction of mesopores calculated from the benzene vapor adsorption/desorption isotherms at 293 K. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and small-angle X-ray scattering (SAXS) investigations of ACs revealed their heterogeneous morphology and chemical composition determined by the precursor and activation conditions. A thermodynamic analysis of methane adsorption at pressures up to 25 MPa and temperatures from 178 to 360 K extended to impacts of the nonideality of a gaseous phase and non-inertness of an adsorbent made it possible to evaluate the heat effects and thermodynamic state functions in the methane-AC adsorption systems. At 270 K and methane adsorption value of ~8 mmol/g, the isosteric heat capacity of the methane-AC-4 system exceeded by ~45% that evaluated for the methane-AC-6 system. The higher micropore volume and structural heterogeneity of the more activated AC-6 compared to AC-4 determine its superior methane adsorption performance.
Behind the Curtain of the Compartmentalization Process: Exploring How Xylem Vessel Diameter Impacts Vascular Pathogen Resistance.

A key determinant of plant resistance to vascular infections lies in the ability of the host to successfully compartmentalize invaders at the xylem level. Growing evidence supports that the structural properties of the vascular system impact host vulnerability towards vascular pathogens. The aim of this study was to provide further insight into the impact of xylem vessel diameter on compartmentalization efficiency and thus vascular pathogen movement, using the interaction between Vitis and Phaeomoniella chlamydospora as a model system. We showed experimentally that an increased number of xylem vessels above 100 μm of diameter resulted in a higher mean infection level of host tissue. This benchmark was validated within and across Vitis genotypes. Although the ability of genotypes to restore vascular cambium integrity upon infection was highly variable, this trait did not correlate with their ability to impede pathogen movement at the xylem level. The distribution of infection severity of cuttings across the range of genotype's susceptibility suggests that a risk-based mechanism is involved. We used this experimental data to calibrate a mechanistic stochastic model of the pathogen spread and we provide evidence that the efficiency of the compartmentalization process within a given xylem vessel is a function of its diameter.
Association of GHR Polymorphisms with Milk Production in Buffaloes

Simple Summary The present study reported two missense mutations in the buffalo GHR gene: A novel (c.380G>A) and (c.836T>A) which was described in previous studies. These two single nucleotide polymorphisms (SNPs) were found to be associated with milk yield, fat %, protein %, and 305 day-milk, fat and protein yield, with higher performance for AA haplotype animals. Therefore, selection of buffaloes with AA haplotype would more likely improve milk production traits. Consequently, this would allow breeders to take more precise selection decisions, leading to significantly higher productivity and profitability within the Egyptian buffalo herds. Abstract For its role in the mediation of growth hormone (GH) galactopoietic effect, growth hormone receptor (GHR) was considered a functional candidate gene for milk performance in cattle. However, its genetic variation and potential effect have not been investigated in Egyptian buffaloes. This study aimed to screen GHR for polymorphisms and study their associations with milk traits in Egyptian buffaloes. Polymerase chain reaction, single-strand conformation polymorphism, and sequencing were used to identify mutations in 4 exons (E4–E6 and E8) of the GHR gene in 400 Egyptian buffaloes. No polymorphisms were found in E4, while 2 SNPs (c.380G>A/p.Arg127Lys and c.387C>T/p.Gly129) in E5, one silent mutation (c.435A>G/p.Pro145) in E6, and another missense mutation (c.836T>A/p.Phe279Tyr) in E8 were detected. The c.380G>A SNP in the extracellular domain was associated with milk yield, fat %, protein %, and 305-day milk, fat and protein yield, with higher levels in animals carrying the mutant A allele. The c.836T>A SNP in the transmembrane domain was associated with milk yield, fat %, protein %, and 305-day milk, fat and protein yield, with higher milk yield and lower fat %, protein %, fat and protein yield in the mutant A allele-animals. Interestingly, animals with the two mutant AA alleles produced higher milk yield, fat %, protein %, fat and protein yield, accompanied with upregulated expressions of GHR, GH, insulin-like growth factor 1 (IGF1), prolactin (PRL), prolactin receptor (PRLR), β-casein (encoded by CSN2 gene), and diacylglycerol acyltransferase-1 (DGAT1) genes and proteins in milk somatic cells. Therefore, selection of Egyptian buffaloes with mutant AA haplotypes for the novel c.380G>A SNP and the well-known c.836T>A SNP could improve milk yield and quality in buffaloes.
The Concept of r- and K-Selection: Evidence from Wild Flowers and Some Theoretical Considerations

The relationship of the demographic parameters of a population to its ecological niche constitutes one of the central problems of population biology. A most interesting theoretical notion pertinent to this problem is r- and K-selection (MacArthur 1962; Cody 1966; MacArthur and Wilson 1967; Hairston, Tinkle, and Wilbur 1970; Roughgarden 1971). The central idea of r- and K-selection is that populations living in environments imposing high density-independent (D.I.) mortality (r-strategists) will be selectively favored to allocate a greater proportion of resources to reproductive activities at the cost of their capabilities to propagate under crowded conditions, and conversely, populations living in environments imposing high density-dependent (D.D.) regulation (K-strategists) will be selectively favored to allocate a greater proportion of resources to nonreproductive activities, at the cost of their capabilities to propagate under conditions of high D.I. mortality. From the argument just stated, it may be deduced that the birth rate of an r-strategist will be greater than that of a related K-strategist. However, increased birth rate under conditions of high D.I. mortality is not sufficient evidence for an r-strategy, because, as demonstrated later in this paper, any increase in D.I. mortality must by itself produce a new equilibrium of birth and death rates at higher values of both. The crucial evidence needed for r- and K-selection is whether an organism is allocating a greater proportion of its resources to reproductive activities (r-strategists) than another related one (K-strategist) under any and all D.D. and D.I. mortality conditions.
Clinical features and therapeutic outcomes of patients with papillary thyroid microcarcinomas and larger tumors

Objective The aim of this study was to identify clinical features and therapeutic outcomes of patients with papillary thyroid cancer (PTC) according to tumor diameter and evaluate the correlation of neck lymph node (LN) involvement of papillary thyroid microcarcinoma (PTMC) according to patients’ age. Patients and methods We divided 467 patients into two groups according to tumor diameter: PTMC group (⩽1 cm) and non-PTMC group (>1 cm). The clinical data were analyzed retrospectively. Thereafter, we divided the PTMC patients into three subgroups according to age: young subgroup (<45 years), middle subgroup (45–54 years), and old subgroup (≥55 years). A further study about clinical features, especially the neck LN involvement in three subgroups, was analyzed. Results All patients received radioiodine ablation at least once. There were more patients with a single cancer lesion and cancer in the unilateral lobe, less number of neck LN involvement, fewer patients with neck lymph node metastasis (LNM), and more patients with Hashimoto’s thyroiditis in PTMC group than in non-PTMC group. At the further evaluation, 58.03% patients maintained clinical remission, which was more in the PTMC group than in non-PTMC group. There was no significant difference in recurrence, but the disease-free survival rate of patients in the PTMC group was higher than in the non-PTMC group. In the PTMC group, the radioactive iodine curative ratio in younger patients is lower than that in the other two subgroups. Both the LNM and central LNM (CLNM) rates were significantly higher in young patients compared with older patients. In addition, the LNM-positive group had more male patients, larger tumor size, and higher thyroglobulin antibody level. Both LNM and the CLNM rates were significantly higher in the young subgroup than in the older subgroup. Young and middle age and extrathyroid extension were independent risk factors for neck LNM. Unlike LNM, young age, extrathyroid extension, and male sex were independent risk factors for CLNM. Conclusion Some PTMCs were less aggressive and the therapeutic outcomes of them were better than non-PTMC. Moreover, PTMCs in young patients were more aggressive, especially in LNM. Hence, clinicians should consider an individualized treatment according to tumor characteristics and age to achieve better therapeutic efficacy.
Head-to-Head Evaluation of 18F-FES and 18F-FDG PET/CT in Metastatic Invasive Lobular Breast Cancer

Visual Abstract Invasive lobular carcinoma (ILC) demonstrates lower conspicuity on 18F-FDG PET than the more common invasive ductal carcinoma. Other molecular imaging methods may be needed for evaluation of this malignancy. As ILC is nearly always (95%) estrogen receptor (ER)–positive, ER-targeting PET tracers such as 16α-18F-fluoroestradiol (18F-FES) may have value. We reviewed prospective trials at Memorial Sloan Kettering Cancer Center using 18F-FES PET/CT to evaluate metastatic ILC patients with synchronous 18F-FDG and 18F-FES PET/CT imaging, which allowed a head-to-head comparison of these 2 PET tracers. Methods: Six prospective clinical trials using 18F-FES PET/CT in patients with metastatic breast cancer were performed at Memorial Sloan Kettering Cancer Center from 2008 to 2019. These trials included 92 patients, of whom 14 (15%) were of ILC histology. Seven of 14 patients with ILC had 18F-FDG PET/CT performed within 5 wk of the research 18F-FES PET/CT and no intervening change in management. For these 7 patients, the 18F-FES and 18F-FDG PET/CT studies were analyzed to determine the total number of tracer–avid lesions, organ systems of involvement, and SUVmax of each organ system for both tracers. Results: In the 7 comparable pairs of scans, there were a total of 254 18F-FES–avid lesions (SUVmax, 2.6–17.9) and 111 18F-FDG–avid lesions (SUVmax, 3.3–9.9) suggestive of malignancy. For 5 of 7 (71%) ILC patients, 18F-FES PET/CT detected more metastatic lesions than 18F-FDG PET/CT. In the same 5 of 7 patients, the SUVmax of 18F-FES–avid lesions was greater than the SUVmax of 18F-FDG–avid lesions. One patient had 18F-FES–avid metastases with no corresponding 18F-FDG–avid metastases. There were no patients with 18F-FDG–avid distant metastases without 18F-FES–avid distant metastases, although in one patient liver metastases were evident on 18F-FDG but not on 18F-FES PET. Conclusion: 18F-FES PET/CT compared favorably with 18F-FDG PET/CT for detection of metastases in patients with metastatic ILC. Larger prospective trials of 18F-FES PET/CT in ILC should be considered to evaluate ER-targeted imaging for clinical value in patients with this histology of breast cancer.
Mechanical Properties and Environmental Evaluation of Ultra-High-Performance Concrete with Aeolian Sand

Ultra-high-performance concrete (UHPC) has received increasing attention in recent years due to its remarkable ductility, durability, and mechanical properties. However, the manufacture of UHPC can cause serious environmental issues. This work addresses the feasibility of using aeolian sand to produce UHPC, and the mix design, environmental impact, and mechanical characterization of UHPC are investigated. We designed the mix proportions of the UHPC according to the modified Andreasen and Andersen particle packing model. We studied the workability, microstructure, porosity, mechanical performance, and environmental impact of UHPC with three different water/binder ratios. The following findings were noted: (1) the compressive strength, flexural strength, and Young’s modulus of the designed UHPC samples were in the ranges of 163.9–207.0 MPa, 18.0–32.2 MPa, and 49.3–58.9 GPa, respectively; (2) the compressive strength, flexural strength, and Young’s modulus of the UHPC increased with a decrease in water/binder ratio and an increase in the steel fibre content; (3) the compressive strength–Young’s modulus correlation of the UHPC could be described by an exponential formula; (4) the environmental impact of UHPC can be improved by decreasing its water/binder ratio. These findings suggest that it is possible to use aeolian sand to manufacture UHPC, and this study promotes the application of aeolian sand for this purpose.
Applying an Extended Task-Technology Fit for Establishing Determinants of Mobile Learning: An Instant Messaging Initiative

The high proliferation of mobile instant messaging (MIM) among university students creates opportunities for a new wave of mobile learning. However, correlational methods for assessing factors that influence student performance impacts on MIM platforms for learning are blurry. The task-technology fit theory has been widely used in the past in predicting performance impacts of users after using new technology. Despite the momentum gained by this framework in the information systems community, it lacks focus on user characteristics. The purpose of this study is to develop an extended model for task-technology fit through an integration of individual antecedent characteristics. Data were collected from 223 participants using a survey questionnaire. The analysis was performed using the partial least squares approach to structural equation modelling. The findings of the study confirmed the original task-technology fit hypotheses considered in this study. Study findings associated with individual antecedent characteristics indicate that perceived ease of use and perceived usefulness of the academic use of the MIM positively influence task-technology fit, while social influence was found to have no significant bearing on task-technology fit.
Optimization for customized trajectories in cone beam computed tomography

Purpose We developed a target‐based cone beam computed tomography (CBCT) imaging framework for optimizing an unconstrained three dimensional (3D) source‐detector trajectory by incorporating prior image information. Our main aim is to enable a CBCT system to provide topical information about the target using a limited angle noncircular scan orbit with a minimal number of projections. Such a customized trajectory should include enough information to sufficiently reconstruct a particular volume of interest (VOI) under kinematic constraints, which may result from the patient size or additional surgical or radiation therapy‐related equipment. Methods A patient‐specific model from a prior diagnostic computed tomography (CT) volume is used as a digital phantom for CBCT trajectory simulations. Selection of the best projection views is accomplished through maximizing an objective function fed by the imaging quality provided by different x‐ray positions on the digital phantom data. The final optimized trajectory includes a limited angular range and a minimal number of projections which can be applied to a C‐arm device capable of general source‐detector positioning. The performance of the proposed framework is investigated in experiments involving an in‐house‐built box phantom including spherical targets as well as an Alderson‐Rando head phantom. In order to quantify the image quality of the reconstructed image, we use the average full‐width‐half‐maximum (FWHMavg) for the spherical target and feature similarity index (FSIM), universal quality index (UQI), and contrast‐to‐noise ratio (CNR) for an anatomical target. Results Our experiments based on both the box and head phantom showed that optimized trajectories could achieve a comparable image quality in the VOI with respect to the standard C‐arm circular CBCT while using approximately one quarter of projections. We achieved a relative deviation <7% for FWHMavg between the reconstructed images from the optimized trajectories and the standard C‐arm CBCT for all spherical targets. Furthermore, for the anatomical target, the relative deviation of FSIM, UQI, and CNR between the reconstructed image related to the proposed trajectory and the standard C‐arm circular CBCT was found to be 5.06%, 6.89%, and 8.64%, respectively. We also compared our proposed trajectories to circular trajectories with equivalent angular sampling as the optimized trajectories. Our results show that optimized trajectories can outperform simple partial circular trajectories in the VOI in term of image quality. Typically, an angular range between 116° and 152° was used for the optimized trajectories. Conclusion We demonstrated that applying limited angle noncircular trajectories with optimized orientations in 3D space can provide a suitable image quality for particular image targets and has a potential for limited angle and low‐dose CBCT‐based interventions under strong spatial constraints.