Miracle-dz/UniFAR-FTUs huggingface dataset:
CLINICAL AND PARACLINICAL CORRELATIONS AND TREATMENT OF THE PATIENTS WITH ZENKER’S DIVERTICULUM

Zenker’s diverticulum is a rare disease, clinically manifested by dysphagia, particularly at the aged patients, with multiple comorbidities. The aim of this study is to correlate the age of the patients with their gender, number of symptoms upon hospitalization, period of hospitalization, post-interventional symptomatology (remaining dysphagia, degree of dysphagia, sialorrhea), dimension of the diverticulum, dimensional classification of the diverticulum, presence of diverticulitis, type of intervention, myotomy, resection of the diverticulum, re-intervention, intra-procedural complications, post-procedural complications, comorbidities, and to correlate the dimensions of the diverticula with the degrees of dysphagia at the patients with Zenker’s diverticulum. We have included in the study 36 patients with cervicomediastinal Zenker’s diverticula treated in the period 2010/ 2017 in two academic clinics: 7 patients with classic surgical method, at the Clinic of General and Oesophageal Surgery – Clinical Hospital “Sfanta Maria” of Bucharest, and 29 patients with endoscopic procedure, at the Department of Diagnostic and Interventional Digestive Endoscopy within the Regional Institute of Hepatology and Gastroenterology “Prof Dr Octavian Fodor” of Cluj-Napoca. The age of the patients was between 42 and 84 years old, and 15 patients were in their 70s. Comparing the patients aged below 70s (N=21) to the lot of patients aged above 70s (N=15), there is no statistically significant difference as regards gender, symptomatology, degree of dysphagia, dimension or degree of the diverticulum, presence of diverticulitis, type of intervention, period of hospitalization, presence of complications or necessity of re-intervention. In the study lot, 55.6% of the patients had 2nd degree dysphagia. The ENT-related symptomatology was present at 10 patients out of the 36 who were in the study and consisted in dysphonia, cough, odynophagia, and was associated with oesophageal manifestations at 70% of the patients. Most of the patients had 1st and 2nd degree diverticula, only 4 patients had 3rd degree diverticula. Comparing the dimensions of the diverticula, expressed in centimetres, with the degrees of dysphagia, upon the patients’ coming to the hospital, no statistical significance can be seen. The patients over 70 years old do not present more advanced stages of the disease, they do not need different treatment and they have no different prognostic as compared to the patients below 70. The patients without dysphagia had 1st and 2nd degree diverticula. Though not significant statistically, all the patients with 3rd degree diverticula had dysphagia.
High-dose therapy and autologous hematopoietic progenitor cells transplantation for relapsed or refractory hodgkin lymphoma: a follow up analysis of king hussein cancer center,results and prognostic variables

Introduction: High dose chemotherapy and autologous stem cell transplantation is a standard of care for patients with relapsed refractory Hodgkin’s Lymphoma. Several factors including number of chemotherapy lines received before conditioning, time of relapse and remission status before transplantation can predict overall survival (OS) and progression free survival (PFS) in patients undergoing autologous stem cell transplantation.Abdel-Rahman et alreported on 63 patients, who underwent high dose chemotherapy followed by autologous stem cell transplantation at KHCC from 2003 to 2008.Here in , we report on the outcome of 86 patients, who underwent high dose chemotherapy and autologous HCT at single institution. Patients and methods: Patients with relapsed and/or refractory Hodgkin’s Lymphoma, Jan,2009-Dec,2016,who underwent high dose chemotherapy and autologous stem cell transplantation were retrospectively analyzed. The primary end points were complete remission (CR) at day 100, progression free survival (PFS0, overall survival (OS) and the impact of the following variables on overall survival and progression free survival: (a) disease status at the time of transplant, (b) number of chemotherapy lines prior to conditioning, (c) time of relapse <12 or > 12 months, (d) age group was also investigated. Secondary end points are day 100 nonrelapse mortality (NRM) and incidence of grade 3-4 mucositis. Results: 50% of patients were in complete remission at the time of transplantation and 69.2% achieved complete remission at day 100.Median overall survival was not reached and an estimated 5-year overall survival 68.8% ± 5.9%, (95% confidence interval [CI], 55.6, 78.8%). Median PFS 10.6 months and an estimated 5-year progression free survival rate 51.1% ± 6.58%( 95% confidence interval [CI], 37.6, 63%). None of the variables studied was significant for survival outcomes . There is a trend toward improved event free survival in those, who received 2 or less lines of chemotherapy.Unexpectidly, male gender was the only significant factor for improved overall survival, progression free survival and event free survival. TRM is 2.7% and mucositis occurred in 53% of patients. Conclusion: The outcome of relapsed refractory HL is favorable and comparable with worldwide reported outcomes. None of the variables studies was significant for survival outcomes. Two or less salvage chemotherapy lines showed a trend toward improved progression free survival. *Correspondence to: Halahleh Khalid, King Hussein Cancer Center, P.O. Box 1269 Al-Jubeiha, Amman 11941, Jordan, Tel: 00972598511670; E-mail: kh.06314@khcc.jo
Acceptability of Home-Based Human Immunodeficiency Virus Testing and Counseling in Low- and Middle-Income Countries: A Systematic Scoping Review

Abstract Evidence on the acceptability of home-based human immunodeficiency virus testing and counseling (HB-HTC) in low- and middle-income countries (LMICs) remains unclear. We aimed to map evidence on the acceptability of HB-HTC in LMICs. We searched PubMed, EBSCOhost, Google Scholar, Science Direct, World Health Organization library database, and UNAIDS databases from January 2013 to October 2017. Two independent reviewers screened the studies using the eligibility criteria both at abstract and full article screening stages as well as performing quality assessment of the included articles. Discrepancies at the abstract stage were resolved through discussions while a third reviewer was involved at the full article screening stage. The risk of bias of included studies was appraised using Mixed Methods Appraisal Tool version 2011. Thematic content analysis was performed to identify patterns of acceptability of HB-HTC. Of 620 studies identified from the data bases searched, 30 studies were included for data extraction. All included studies were published between 2013 and 2017. Most of the study participants from these included studies were aged between 18 months to 100 years comprising of males (59%) and females (41%). These included studies were conducted in diverse locations including South Africa, Kenya, Lesotho, Malawi, China, Zimbabwe, Zambia, Uganda, and Brazil. Most of the studies were conducted in South Africa (9) and Kenya (7). Evidence showed that HB-HTC was most accepted by the female population compared with males in LMICs. In conclusion, there is adequate evidence on acceptability of HB-HTC in LMICs and linkage to care. This study additionally demonstrates that HB-HTC approach was more acceptable compared with facility-based HTC.
FAKTOR YANG MEMPENGARUHI STUNTING PADA BALITA USIA 24-59 BULAN DI PUSKESMAS CEPU KABUPATEN BLORA

Stunting is a failure in children under five years due to chronic malnutrition so that children are too short of the WHO 2005 standard height, that is the z-score is less than -2SD or -3SD. The purpose of this study was to determine the risk factors for the incidence of stunting in infants aged 24-59 months in the working area of Cepu Health Center, Blora Regency. This study uses observational analytic studies with case control methods. The sample used was 76 toddlers consisting of 38 cases and 38 controls. The research instrument used was the method of recalling 2 x 24 hours of nutritional consumption and assisted with a list of URT to estimate the weight of food in grams. Data analysis using chi-square test. The results showed that the lack of level of energy sufficiency (OR=5,318, CI=1,997 – 14,163), the lack of maternal nutritional knowledge (OR=4,720, CI=1,790 – 12,450) and low family income per capita (OR= 5,385, CI=2,011 – 14,421) is a risk factor for the incidence of stunting in infants. Other factors in this study such as lack of protein adequacy (CI=0.167 – 1.928), history of low birth weight (LBW) (CI=0.318 – 5.219), history of ASI is not exclusive (CI=362 – 0,597), maternal education (CI= 0,315 – 31,946) and working mothers (CI=688 – 4,474) are not risk factors for stunting. Per capita family income is a risk factor that most influences the incidence of stunting in this study. It is expected that the Cepu Health Center can improve the nutritional knowledge of mothers and provide adequate energy nutritious food assistance, mothers under five provide the right nutrition according to the Nutrition Adequacy Rate of children under five, and the head of the family increases the income per capita of the family.
The longleaf pine forests of the southeast: requiem or renaissance?

VAST FORESTS OF LONGLEAF PINE (P1M.B PALUSTRIS) GREETED the first European settlers of the lower Atlantic Coastal Plain of the Carolinas and Georgia. At that time, this species may have dominated as much as 92 mil l ion acres throughout the southeastern United Srates (Frost 1933). Only about 20 million acres of longlraf pine forest were left by 1935 (Wahlenberg 1946). These forests declined to less than 5 million acrrs by 1975, and within the next decade to 3.8 million acres (Kelly and Bechtold 1330). A more recent update (USDA Forest Service, Forest Inventory and Analysis, unpubl. data) puts the total at about 3.2 million acres. Losses since rhen have likely i-cduced remaining longleaf forests to less than 3 million acres.
Implementation of Chi Square Automatic Interaction Detection (CHAID) Method to Identify Type 2 Diabetes Mellitus in Tuberculosis Patient. A Case Study in Cipto Mangunkusumo Hospital

A Pulmonary Tuberculosis (pulmonary TB) is a chronic infectious disease caused by Mycobacterium tuberculosis. Chronic infection cause the body in a state of oxidative stress. In the state of stress, stress hormone production increases and can affect the increase of blood sugar levels which then trigger the occurrence of diabetes mellitus (DM). The purpose of this study is to determine the factors associated with the emergence of DM Type 2 and make a classification to characterize DM Type 2 in patients with pulmonary TB. In this research, the data used are secondary data of pulmonary TB patients obtained from Cipto Mangunkusumo Hospital (RSCM) for six years, 2012 - 2017. Chi Square Automatic Interaction Detection (CHAID) method is used to classify categorical data by dividing the data set into subgroups. The dependent variable is type 2 DM status, and the independent variables are gender, age, body mass index, level of neutrophil, level of lymphocytes, erythrocyte sedimentation rate, and anti-tuberculosis medicines such as rifampicin, isoniazid, pyrazinamide, ethambutol, and streptomicin. There are seven classes are obtained by classification using CHAID. The result from analysis of CHAID method shows that the factors related to the occurrence of type 2 DM on TB patients are age, body mass index, gender and pirazinamid (Z). Based on CHAID method, a classification of the occurrence of type 2 DM on pulmonary TB patients is obtained, which is pulmonary TB patients who are ≥ 40 years old, have body mass index ≥ 25 kg/m2, and the most patients are male (Class-4th).
Treponema pallidum-specific immune responses and autoimmunity in patients who remain serofast after treatment of syphilis

Introduction Approximately 15% of appropriately treated patients with early syphilis remain serofast. The pathogenesis and clinical significance of this phenomenon are unclear. Aim To determine the significance of Treponema pallidum-specific immune responses and autoimmunity in the treatment outcome of syphilis (serofast or proper serological response). Material and methods Forty-eight patients with secondary and early latent syphilis (ELS) were enrolled in this study. Reactivity of IgM/IgG antibodies to the treponemal antigens TpN47, TpN17, TpN15 and TmpA was evaluated before and 12 months after intramuscular penicillin therapy for syphilis. Additionally, the presence of antinuclear antibodies (ANA) was determined 12 months after treatment. Results After 1 year, patients were stratified into two groups based on their serological response: (1) serofast (n = 10) and (2) serologically-cured (n = 38) patients. The serological cure rate was 79.2% at 12 months after treatment. Weak pre- and post-treatment antibody reactivity to TpN47 antigen was found to be significantly associated with a higher risk of the serofast state (OR = 64; 95% CI: 5.01–817; p < 0.005). Patients who remained serofast had a significantly higher ANA prevalence and mean titer when compared to those with proper serological responses (100% vs. 5.3%, respectively, p < 0.005; 1 : 640 vs. 1 : 160, respectively, p < 0.005). Conclusions We demonstrate that baseline antigen-specific immune response to Treponema pallidum may be an important predictor of the treatment outcome. Further studies are warranted to identify the role of autoimmunity in the pathomechanism of the serofast state.
Effects of Day Temperature and Light Intensity on Growth and Composition of Vitis vinifera L. Fruits1

Three-year-old ‘Cardinal’ and ‘Pinot noir’ vines were grown from véraison to fruit maturity in a stationary and rotating phytotron at high (30°C) and low (20°C) day temperatures in combination with both high (>2,500 ft-c) and low (< 1,200 ft-c) average light intensities. Night temperature (6 PM to 6 AM) was 15°C in all treatments. Berries were collected at weekly intervals and analyzed for various constituents. Low temperature usually resulted in increased berry weight, total acidity, and malate, and in decreased pH, arginine, proline, and total N in the berry juices, as compared to fruits grown at high temperature. The concentrations of total soluble solids and tartrate in the fruits generally did not significantly differ with temperature. Low light intensity at both high and low temperatures generally resulted in reduced berry weight, total soluble solids, pH, and proline, and in increased levels of total acidity, malate, arginine, and total N in the berry juices compared to grapes grown at high light intensity at the same room temperature. The concentration of arginine was highly correlated with the level of total N in the fruits of both cultivars.
Dental caries, tooth wear and dietary sugar intake in a sample of Northland Māori.

6 Acknowledgements . 8 Preface . 10 List of Figures . 11 List of Tables . 12 List of Abbreviations . 14 Literature review . 15 Chapter 1 . 15 1.
The Diet of Besra Sparrowhawk (Accipiter virgatus) in Yangmingshan Area, Northern Taiwan

We monitored 25 Besra Sparrowhawk (Accipiter virgatus) nests from 1993 to 2002 in Yangmingshan, northern Taiwan, to document the prey composition of this species during the breeding season. Results showed that birds were the major prey both in frequency and in biomass. Besra Sparrowhawk preyed more on species active in canopy, mid-layer, and shrubs than on the ground. There were seasonal shifts in prey composition and diet diversity indices. We suggest that Besra Sparrowhawk captured prey opportunistically, capitalizing on seasonally emerging prey species that are abundant and energetically rewarding to catch.
Biochemical Composition of Dissolved Organic Matter Released During Experimental Diatom Blooms

An axenic culture of Skeletonema costatum was grown to late-log phase to examine the molecular weight distribution and the biochemical composition of high molecular weight dissolved organic matter released in the absence of actively growing bacteria. A second culture was grown in a 5 m(exp 3) mesocosm and placed in darkness for a period of 51 days to examine the impact of phytoplankton bloom dynamics and microbial decomposition on dissolved (DOM) and particulate organic matter (POM) composition. DOM was separated using tangential-flow ultrafiltration into three nominal size fractions: LDOM (less than 1 kDa DOM), HDOM (1-30 kDa) and VHDOM (30 kDa-0.2 micron) and characterized. Both axenic and mesocosm diatom blooms released 28-33% of net primary production as dissolved organic carbon (DOC). In the axenic culture, HDOM and LDOM each comprised about half of the diatom-released DOC with less than l% as VHDOM. Diatoms from both experiments released carbohydrate-rich high molecular weight DOM. Much of the axenic diatom-released high molecular weight DOC could be chemically characterized (61% of HDOM and 78% of VHDOM) with carbohydrates as the primary component (45% of HDOM and 55% of VHDOM). Substantial amounts of hydrolyzable amino acids (16% of HDOM and 22% of VHDOM) and small amounts of lipids (less than 1%) were also released. Proportions of recognizable biochemical components in DOM produced in the mesocosm bloom were lower compared to the axenic culture. The presence of bacterial fatty acids and peptidoglycan-derived D-amino acids within high molecular weight fractions from the mesocosm bloom revealed that bacteria contributed a variety of macromolecules to DOM during the growth and decay of the diatom bloom. Release of significant amounts of DOC by diatoms demonstrates that DOM excretion is an important component of phytoplankton primary production. Similarities in high molecular weight DOM composition in marine waters and diatom cultures highlight the importance of phytoplankton to DOM composition in the ocean.
Effect of salt stress on root ultrastructure of Fraxinus americana and Prunus maritima.

The ultrastructural changes of root cells of Fraxinus americana and Prunus maritima under different salt stresses(CK,3 g/L,9 g/L) for four months were studied by applying transmission electron microscopy.The results showed that the cytoplasm of root cells of Fraxinus americana agglomerated,and the plasmolysis was obvious,organelles were seriously degraded under low-salt stress(3 g/L),The nuclear membrane was partially dissociated from the nuclear,but the root cell wall structure of F.americana was basically normal.While there were no significant changes to root cells of Prunus maritima.Under high-salt stress(9 g/L),root cells of Fraxinus americana were severely damaged,plasmolysis was further developed.While there were more degraded materials accumulated in the root cells of Prunu maritima,and the organelles were degraded under high salt stress.The concentration of nuclear chromatin declined and the nuclear membrane became fuzzy.The cytoplasmic membrane was partially invaginated but there was no obvious plasmolysis observed in the root cells of P.maritima. In comparison,root cells of Fraxinus americana were more seriously damaged under salt stress and Prunus maritima exhibited to be more resistant to salt stress.
Characterisation of 11S protein fractions and phenolic compounds from green coffee beans under special consideration of their interactions - A review

The intention of this study was to increase the knowledge on the composition and structure of coffee bean proteins and the changes induced in them especially with regard to their interactions with the phenolic compounds also present. For this purpose green coffee beans were extracted by means of standard methanol extraction to quantify the chlorogenic acid content. Different solubilisation buffers were applied to extract the protein fractions with or without prior fat removal. The protein samples thus obtained were analysed by different methods (RP-HPLC, SDS-PAGE and SELDI-TOF- MS). Preliminary model studies were performed to characterize the interactions between the isolated green coffee protein fractions and chlorogenic acid (the major phenolic compound in coffee beans) with the intention of fulfilling the ultimate goal of characterizing such reactions in roasted coffee. The results show that the content of chlorogenic bound covalently to the protein increases. A reaction with the nucleophilic protein side chains (tryptophan, cystein and lysine) was recorded. Cross-inked protein polymers were also detected, whereby the a-chain was found to be more reactive. These reactions effect the solubility of the coffee bean proteins, the latter in turn becoming more acidic in nature. The secondary structure was affected only slightly as determined by circular dichroism. The in-vitro tryptic digestibility was also influenced, where again the cc-chain seems to be more susceptible. The observed polymerisation due to derivatisation by chorogenic acid declines the digestion. Similar digestion behaviour was also observed during tryptic hydrolysis of roasted coffee compared to that of green coffee, roasting allowing more stronger denaturation caused by the accompanying Maillard reaction. The derivatised green coffee bean proteins were found to have moderate antioxidative capacity
Responses of lettuce (Lactuca sativa L. var. longifolia) grown in a closed hydroponic system to NaCl- or CaCl2-salinity

Lettuce plants (Lactuca saliva L. var. longifolia) grown in a closed hydroponic system using perlite as substrate were exposed to similar levels of NaCI- and CaCl 2 -salinity in an attempt to distinguish between osmotic and salt-specific effects on plant growth and quality. A standard nutrient solution for lettuce (control) was compared with two salinity levels and each salinity level was imposed by adding either NaCI or CaCl 2 to the standard nutrient solution. The mean electrical conductivity in the root zone, as indicated by the values measured in the drainage solution, was 2.5, 3.7, 3.5, 5.6 and 5.4 dS m - 1 in the control, the low NaCl-, the low CaCl 2 -, the high NaCI- and the high CaCl 2 -salinity treatment, respectively. The increase of NaCl-salinity in the root zone restricted the shoot growth of lettuce. In contrast, the CaCl 2 -salinity had no significant effect on the above-ground growth of the plants. The root growth was not affected by any salinity treatment. The leaf.Cl concentration was increased in all salinity treatments but the NaCl-salinity resulted in significantly higher Cl levels in leaf compared to CaCl 2 -salinity at similar Cl concentrations in the root zone. The leaf Mg concentration was decreased in all salinity treatments but the most marked suppression was observed at the highest CaCl 2 - level. The leaf K was restricted by salinity without significant differences between salinity levels and source. The leaf chlorophyll and ascorbic acid concentrations were not affected by either of the salinity treatments. It was concluded that the effects of salinity on lettuce are primarily Na-specific.
Collagen cross-linking for pediatric refractive correction

Corneal collagen-crosslinking (CXL) has been widely investigated in the adult population. There is still little available in the literature, however, on the effects of CXL in children. A review of the literature on CXL in the pediatric population is presented here, with a particular emphasis on the refractive effects. Although several studies demonstrate promising results, most studies have small sample sizes with relatively short follow-up periods. Further investigation on the effects of CXL in the pediatric population is required to better understand long-term effects.