Miracle-dz/UniFAR-FTUs huggingface dataset:
Trends in Extreme Distress in the United States, 1993-2019.

Objectives. To investigate changes from 1993 to 2019 in the percentage of US citizens suffering extreme distress.Methods. Using data on 8.1 million randomly sampled US citizens, we created a new proxy measure for exceptional distress (the percentage who reported major mental and emotional problems in all 30 of the last 30 days). We examined time trends for different groups and predictors of distress.Results. The proportion of the US population in extreme distress rose from 3.6% in 1993 to 6.4% in 2019. Among low-education midlife White persons, the percentage more than doubled, from 4.8% to 11.5%. Regression analysis revealed that (1) at the personal level, the strongest statistical predictor of extreme distress was "I am unable to work," and (2) at the state level, a decline in the share of manufacturing jobs was a predictor of greater distress.Conclusions. Increasing numbers of US citizens report extreme levels of mental distress. This links to poor labor-market prospects. Inequality of distress has also widened.Public Health Implications. Policymakers need to recognize the crisis of an ever-growing group of US citizens in extreme distress. (Am J Public Health. Published online ahead of print August 20, 2020: e1-e7. doi:10.2105/AJPH.2020.305811).
Going smoke-free: University staff and students’ qualitative views about smoking on campus during the implementation of a smoke-free policy

Background Despite many Australian universities introducing smoke-free policies on campus, there is little information about staff and students understanding of smoking on campus in the context of the implementation of a smoke-free policy. Objective This research explores the qualitative views of university staff and students about smoking on campus during the implementation of a smoke-free policy. Methods In 2016, an electronic survey was distributed to all current staff and students of a large university in Queensland, Australia during the implementation of a smoke-free policy. The survey consisted of multiple-choice questions about demographics, tobacco use, attitudes towards smoking, awareness of and attitudes towards the policy, and intentions to quit smoking. The final question asked for a short, open-ended response: “Would you like to comment on the issue of smoking on QUT* campuses? ” This question was extracted from the survey and analysed using inductive thematic analysis. This paper reports the findings from this question. *Queensland University of Technology. Results The survey was completed by 641 staff and students. There were 351 responses to the final question. Five inductive themes emerged about smoking on campus during the implementation of a smoke-free policy: 1) the watering down of the policy, if it is not enforced, 2) the creation of hot spots on campus boundaries affecting those who pass by, 3) concern, especially by those who don’t smoke, about the impact on smokers emotional health and welfare, 4) disagreement about the value of designated smoking areas and 5) suggestions about how to better implement the policy. Conclusion Overall, participants views about smoking on campus during the implementation of a smoke free policy suggest broad agreement but reflect concerns about enforcement, boundaries, non-smokers and designated areas. Consistent and systematic processes for implementation, maintenance and enforcement of policy goals, and cessation support, is needed to create a non-smoking culture on university campuses.
Clinicopathologic Profile of Sinonasal Neoplasia in Kano, Northwestern Nigeria: A 10-Year Single-Institution Experience

Background: Sinonasal neoplasia comprises approximately 3% of all head-and-neck tumors. However, the incidence of these tumors may be greater in some parts of the world including Asia and Africa. Aim and Objective: The study aimed to review the clinical and histopathological pattern of sinonasal neoplasms in Kano, Nigeria. Materials and Methods: The records of patients managed for sinonasal neoplasia at the Department of Otorhinolaryngology, Aminu Kano Teaching Hospital, Kano, Nigeria, over a period of 10 years were reviewed. Information obtained from the case files included demographic characteristics, tumor characteristics, and clinical information. The data obtained were analyzed using SPSS version 23. Results: A total of 245 patients were reviewed with sinonasal neoplasms. Among these, 168 (68.57%) were males, with a sex ratio (M:F) of 2.18:1. The mean age was 40.2 ± 18.9 years. Malignant sinonasal neoplasm constituted 55.92%% of the sinonasal neoplasia, with peak age at the fifth decade. Squamous cell carcinoma was the most common histological subtypes seen in 50.36% of the patients. Inverted papilloma was the most common benign sinonasal neoplasia (42.59%). The most common symptom presented by the patients was nasal obstruction (77.55%), mostly presented within 6 months of onset of symptoms (63.67%), and farmers were the predominant (27.76%). The most common treatment modality was surgical extirpation (54%), and most of the patients presented with Stage IV disease (88%). The site of tumor was found to statistically correlate with the type of tumor among the patients (P ≤ 0.0001), whereas the type of tumor and site of tumor correlated significantly with the duration of symptoms before the presentation. Conclusion: Malignant sinonasal disease is the predominant sinonasal neoplasm in this environment, and most of the patients presented with advanced disease.
HUBUNGAN DYSMENORRHEA DENGAN PRESTASI BELAJAR MAHASISWI JURUSAN KEPERAWATAN

Gangguan fisik yang sangat menonjol pada wanita haid adalah dysmenorrhea. Dysmenorrhea adalah nyeri haid yang dirasakan di bagian perut bagian bawah dan dysmenorrhea membuat wanita tidak bisa beraktivitas secara normal serta dapat menurunkan konsentrasi belajar mahasisiwi karena rasa nyeri yang mereka rasakan. Tujuan penelitian ini adalah untuk mengetahui hubungan dysmenorrhea dengan prestasi belajar. Desain penelitian yang digunakan adalah cross sectional. Cara penarikan sampel dengan menggunakan purposive sampling dengan jumlah sampel sebanyak 65 responden. Adapun instrumen penelitian yang digunakan yaitu kuesioner. Dalam penelitian ini menggunakan analisis uji statistic chi-square dengan tingkat signifikan (α=0,05) dan uji alternatif yang digunakan yaitu uji fisher dan didapatkan nilai p= 0,614. Kesimpulan penelitian ini adalah tidak ada hubungan yang signifikan antara dysmenorrhea dengan prestasi belajar mahasiswi Keperawatan Angkatan 2011 Fakultas Ilmu Kesehatan UIN Alauddin Makassar. Untuk penelitian selanjutnya disarankan agar menambah jumlah sampel dan variabel-variabel lain, seperti faktor psikologi, faktor keluarga, faktor kampus dan faktor masyarakat.
Communal Roosting in Heliconius Butterflies (Nymphalidae): Roost Recruitment, Establishment, Fidelity, and Resource Use Trends Based on Age and Sex

ABSTRACT. Heliconius passion-vine butterflies form communal roosts on a nightly basis as an anti-predatory defense. Although past studies have evaluated various components of this behavior, much remains unknown about many basic aspects of roost dynamics. To learn more about communal roosting I examined roost establishment, recruitment, roost-mate resource use, roosting participation in a population, and roost arrival, departure, and perch preferences in natural populations of Heliconius erato petiverana in Panama. My observations suggest that 1) younger butterflies are recruited more readily than older butterflies, 2) roosts are first established by a single butterfly roosting consecutively in the same location that later recruits butterflies, 3) males depart roosts earlier than females in the morning, 4) older butterflies tend to roost on the same perch in the same roost every night, 5) roost-mates share the same resource traplines, and 6) most butterflies in a population participate in roosts. These observations present an improved portrait of Heliconius roosting and raise several new questions about this behavior.
Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

Cellular senescence is a contributor to intervertebral disc (IVD) degeneration and low back pain. Here, we found that RG-7112, a potent mouse double-minute two protein inhibitor, selectively kills senescent IVD cells through apoptosis. Gene expression pathway analysis was used to compare the functional networks of genes affected by RG-7112, a pure synthetic senolytic with o-Vanillin a natural and anti-inflammatory senolytic. Both affected a functional gene network related to cell death and survival. O-Vanillin also affected networks related to cell cycle progression as well as connective tissue development and function. Both senolytics effectively decreased the senescence-associated secretory phenotype (SASP) of IVD cells. Furthermore, bioavailability and efficacy were verified ex vivo in the physiological environment of degenerating intact human discs where a single dose improved disc matrix homeostasis. Matrix improvement correlated with a reduction in senescent cells and SASP, supporting a translational potential of targeting senescent cells as a therapeutic intervention.
Selective Removal of Sodium Salt Taste Disrupts the Maintenance of Dendritic Architecture of Gustatory Relay Neurons in the Mouse Nucleus of the Solitary Tract

Abstract Neuronal activity plays critical roles in the development of sensory circuits in the mammalian brain. Experimental procedures are now available to alter the function of specific taste transduction pathways and have been especially useful in studying how stimulus-specific taste activity influences the development of central gustatory circuits. We previously used a mouse knock-out (KO) model in which the transduction channel necessary for sodium taste is removed from taste bud cells throughout life. In these KO mice, the terminal fields that carry taste information from taste buds into the nucleus of the solitary tract (NST) fail to mature, suggesting that sodium-elicited taste activity is important for the proper development of central gustatory circuits. Here, we tested the hypothesis that the development and maintenance of the dendritic architecture of NST relay cells, the primary postsynaptic partner of gustatory nerve terminal fields, are similarly dependent on sodium-elicited taste activity. The dendritic fields of NST relay cells, from adult male and female mice in which the α-subunit of the epithelial sodium channel (αENaC) was conditionally deleted in taste bud cells throughout life, were up to 2.4× larger and more complex than that of age-matched control mice. Interestingly, these differences in dendritic architecture did not appear until after the age when terminal fields begin “pruning,” after postnatal day (P)20. Overall, our results suggest that ENaC-mediated sodium taste activity is necessary for the maintenance of dendritic fields of relay cells in the gustatory NST.
Ambrosia Beetle (Coleoptera: Curculionidae: Scolytinae) Captures Using Colored Traps in Southeast Tennessee and South Mississippi

Abstract Ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) have become a major impediment to profitable nursery production, with proper controls centered around an accurate monitoring program. Whereas the use of semiochemicals by ambrosia beetles is well understood, the potential use of visual cues including colors remains relatively understudied. Field tests were performed in Tennessee and Mississippi to determine response of the ambrosia beetle community to 13 trap colors (black, blue, brown, clear, gray, green, lavender, opaque, orange, purple, red, white, and yellow). Traps consisted of corrugated plastic in the shape of a prism and covered in insect glue (Pestick™ or Tangle-Trap®). All trap colors were analyzed with a spectro-photometer to quantify spectral reflectance, ranging from 6 - 80% reflectance. Mean ambrosia beetle capture from opaque and red traps (60 and 54, respectively) was significantly higher than from yellow or white traps (30 and 28, respectively). However, captures from each of the afore-mentioned 4 colors were not significantly different from the other 9 colors tested. Although further research is needed to explain the efficacy of the opaque traps, we can recommend that industry-standard black traps are an acceptable choice for ambrosia beetle monitoring programs; whereas, yellow or white traps are not recommended.
Production improvement through phosphorus fertilization and legume introduction in grazed native pastures of Uruguay

SUMMARY The objective of the current study was to quantify the response of pasture to phosphorus (P) fertilizer application and legume introduction, by measuring herbage yield, nitrogen (N) and P content, and weight gain of calves in native pastures of Uruguay. Quantitative relationships between pasture characteristics and post-weaning daily live weight gain (DLWG) were also examined. The treatments studied were native grassland (NG) and improved pasture, oversown with Lotus corniculatus L. and Trifolium repens L. with annual applications of either 13 and 26 kg P/ha. From 1996 to 2001 the treatments were evaluated each year with a new group of calves. Total herbage yields of the oversown pastures were not always higher than NG in the initial years, but legume production increased, although without significant differences between P rates on legume or total yield. This was also reflected in the N and P status of the swards. In the last 2 years legume proportion had declined to <0·1, but total herbage yield was significantly higher in the improved pastures. The average DLWG over the 6 years of measurements were 0·319, 0·478 and 0·586 kg/day for NG, P1 and P2, respectively, with average total live weight gain increased 1·8- and 2·5-fold by the legume introduction and annual addition of 13 and 26 kg P/ha, respectively. The study demonstrated that the evaluation of pasture response to P application should not be limited to assessing forage yield increase. Phosphorus availability in the herbage was a better predictor of animal performance than pasture yield. The study highlights that the benefits of oversowing and fertilizer inputs are short-lived, as withholding of fertilizer in the last 2 years resulted in a loss of sown legumes and decline in animal production.
Effect of condensed tannin supplementation through a tree leaves mixture on erythrocytic antioxidant status and gastrointestinal nematodes in kids

In order to assess the effect of condensed tannins (CT) through tanniferous tree leaves on erythrocytic antioxidant status and GI nematodes, indigenous kids (n=18) were randomly divided into 3 groups of 6 each and fed iso-nitrogenous diets to contain 0 (CT-0), 1.0 (CT-1) and 2.0 (CT-2)% CT through a dried and ground leaf meal mixture of Ficus infectoria, Psidium guajava and Ficus bengalensis. Blood-biochemical profile and erythrocytic antioxidant status was monitored in all the kids at 0, 40, 80 and 120d of feeding. Supplementation of CT upto 2.0% of diet for 120d showed a significant (P<0.001) improvement on the performance of kids. Total BW gain and ADG were higher (P<0.001) in both CT supplemented groups than control. Feed conversion ratio was higher (P<0.001) in CT-2 followed by CT-1 and CT-0, respectively. Haemoglobin, PCV, serum glucose, total protein were similar among the dietary treatments except for a reduction (P<0.01) in serum urea level in CT-fed kids. There was improvement (P<0.05) in erythrocytic antioxidant status n the CT supplemented groups evident from increased concentrations of superoxide dismutase, reduced glutathione, catalase and total thiol groups concomitant to a reduction in lipid peroxidation as compared to the control. Feeding of CT containing diets up to 2.0% level significantly (P<0.05) decreased the faecal egg counts when compared with the control group. It may be concluded that a mixture of tree leaves (containing 1–2% CT) has the potential to improve antioxidant status with an apparent negative impact on GI nematodes in kids.
Gonadotropin Induced Synchronous Changes of Morphology and Gonadal Development in the Japanese Eel Anguilla japonica

In a previous study, we had observed synchronous changes of morphology and gonadal development in wild Japanese eel during the silvering process. In this study, we aimed to clarify if gonadotropin is the key hormone responsible for this phenomenon. Yellow eels captured in the Kaoping River were repeatedly injected with human chorionic gonadotropin (HCG), and changes of morphology and gonadal development were examined. After five weekly injection of HCG at a dosage of 0.75 IU/g body weight, eels was classified into well-responsive and poor-responsive groups according to skin coloration. Approximately 50 % of males and 20 % of females were responsive to become silver eels. Mean age, total length, body weight, condition factor, gonadosomatic index (GSI), fin-index (FI), hepatosomatic index (HSI) and ocular index (OI) were significantly higher in well-responsive eels than in poorresponsive eels. In contrast, the mean digestosomatic index (DSI) significantly decreased in wellresponsive eels. OI was positively correlated and DSI was negatively correlated with the GSI in both sexes. These results indicated that well developed eels are more sensitive to HCG treatment, and the skin color, eye size, gonadal development and digestive tract shrinkage were synchronous after HCG injection. The pituitary-gonad axis plays important role on eel silvering.
Screening for Obstructive Sleep Apnea in Children With Sickle Cell Disease: A Pilot Study

Obstructive sleep apnea (OSA) and sickle cell disease (SCD) represent two complex disease processes. Current guidelines recommend that children with SCD receive polysomnography (PSG) after presenting with signs or symptoms of sleep‐disordered breathing (SDB). Recent studies suggest a disproportionately elevated prevalence of SDB in the population of children with SCD, and traditional risk factors may not be evident within these patients. Further objective testing might be needed to screen all pediatric patients with SCD, even in the absence of overt signs or symptoms of OSA to prevent complications of both conditions.
Thoracic Outlet Syndrome: Historical Aspects of Anatomy and Physiology

Throughout the years complexes of symptoms of the upper extremity, caused by compression, were to be explained. Pain, paresthesia, edema, ischemia and motor dysfunction of the arm was and still is a diagnostic problem. From the start many separated syndromes have been developed in order to explain the patientrsquos problems which at the end came they all together to a nosological entity, the thoracic outlet compression syndrome (TOS). This paper reviews the evolution of the syndromes throughout the years and the historical landmarks that formed this multifactorial problem as we understand it today.
Safety and Clinical Activity of MEDI0562, a Humanized OX40 Agonist Monoclonal Antibody, in Adult Patients with Advanced Solid Tumors

Purpose: Immune checkpoint blockade has demonstrated clinical benefits across multiple solid tumor types; however, resistance and relapse often occur. New immunomodulatory targets, which are highly expressed in activated immune cells, are needed. MEDI0562, an agonistic humanized mAb, specifically binds to the costimulatory molecule OX40. This first-in-human study evaluated MEDI0562 in adults with advanced solid tumors. Patients and Methods: In this phase I, multicenter, open-label, single-arm, dose-escalation (3+3 design) study, patients received 0.03, 0.1, 0.3, 1.0, 3.0, or 10 mg/kg MEDI0562 through intravenous infusion every 2 weeks, until confirmed disease progression or unacceptable toxicity. The primary objective evaluated safety and tolerability. Secondary endpoints included antitumor activity, pharmacokinetics, immunogenicity, and pharmacodynamics. Results: In total, 55 patients received ≥1 dose of MEDI0562 and were included in the analysis. The most common tumor type was squamous cell carcinoma of the head and neck (47%). Median duration of treatment was 10 weeks (range, 2–48 weeks). Treatment-related adverse events (TRAEs) occurred in 67% of patients, most commonly fatigue (31%) and infusion-related reactions (14%). Grade 3 TRAEs occurred in 14% of patients with no apparent dose relationship; no TRAEs resulted in death. Two patients had immune-related partial responses per protocol and 44% had stable disease. MEDI0562 induced increased Ki67+ CD4+ and CD8+ memory T-cell proliferation in the periphery and decreased intratumoral OX40+ FOXP3+ cells. Conclusions: MEDI0562 was safely administered at doses up to 10 mg/kg in heavily pretreated patients. On-target pharmacodynamic effects were suggested in this setting. Further evaluation with immune checkpoint inhibitors is ongoing.
Empiric Antibacterial Therapy and Community-onset Bacterial Coinfection in Patients Hospitalized With Coronavirus Disease 2019 (COVID-19): A Multi-hospital Cohort Study

Abstract Background Antibacterials may be initiated out of concern for bacterial coinfection in coronavirus disease 2019 (COVID-19). We determined prevalence and predictors of empiric antibacterial therapy and community-onset bacterial coinfections in hospitalized patients with COVID-19. Methods A randomly sampled cohort of 1705 patients hospitalized with COVID-19 in 38 Michigan hospitals between 3/13/2020 and 6/18/2020. Data were collected on early (within 2 days of hospitalization) empiric antibacterial therapy and community-onset bacterial coinfections (positive microbiologic test ≤3 days). Poisson generalized estimating equation models were used to assess predictors. Results Of 1705 patients with COVID-19, 56.6% were prescribed early empiric antibacterial therapy; 3.5% (59/1705) had a confirmed community-onset bacterial infection. Across hospitals, early empiric antibacterial use varied from 27% to 84%. Patients were more likely to receive early empiric antibacterial therapy if they were older (adjusted rate ratio [ARR]: 1.04 [1.00–1.08] per 10 years); had a lower body mass index (ARR: 0.99 [0.99–1.00] per kg/m2), more severe illness (eg, severe sepsis; ARR: 1.16 [1.07–1.27]), a lobar infiltrate (ARR: 1.21 [1.04–1.42]); or were admitted to a for-profit hospital (ARR: 1.30 [1.15–1.47]). Over time, COVID-19 test turnaround time (returned ≤1 day in March [54.2%, 461/850] vs April [85.2%, 628/737], P < .001) and empiric antibacterial use (ARR: 0.71 [0.63–0.81] April vs March) decreased. Conclusions The prevalence of confirmed community-onset bacterial coinfections was low. Despite this, half of patients received early empiric antibacterial therapy. Antibacterial use varied widely by hospital. Reducing COVID-19 test turnaround time and supporting stewardship could improve antibacterial use.