Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparing Intramedullary Nails and Locking Plates in Displaced Proximal Humerus Fracture Management: A Systematic Review and Meta-Analysis

This study aims to provide an updated review comparing the complication rates and clinical outcomes of intramedullary nails and locking plates (LPs) in displaced proximal humerus fracture (PHF) management. We performed a systematic review of the Cochrane Central Register of Controlled Trials, Clinical Trials Registry, EMBASE, and PubMed. Studies with level III evidence or higher comparing intramedullary nails and LPs used for internal fixation of displaced PHFs were included. The Methodological Index for Nonrandomized Studies (MINORS) criteria and Cochrane Handbook for Systematic Reviews of Interventions 5.2. 0 were used to assess the risk of bias. Our meta-analysis included a comparison of method-related complications, pain scores, range of motion (ROM), and functional scores. A total of 13 comparative studies were included: five randomized controlled trials, three prospective cohort studies, and five retrospective cohort studies. The total number of patients included was 1,253 (677 in the LP group and 576 in the intramedullary nail group). Superior Constant-Murley scores and external rotation ROM were found in the LP group during the early postoperative period. However, long-term functional scores and complication rates were comparable between the two groups. We conclude that intramedullary nailing and LP fixation are both equally effective for the treatment of displaced PHFs. Neither treatment appears superior at this time, and more large-scale randomized controlled trials should be conducted to further evaluate the potential benefit of LPs in the early postoperative period.
Sir "Podravec" - tehnologija i kvaliteta

»Podravec', sir Industrije mliječnih proizvoda »Sirela* u Bjelovaru, pro­ izvodi se kombinacijom procesa karakterističnog za empirijsku proizvodnju sira trapista u malim mljekarama na području Republike Hrvatske i nizozem­ skog sira edamca. Istraživanje je provedeno sa svrhom da se utvrde elementi za osnove proizvodnih normativa i standardizaciju procesa proizvodnje te pridonose poboljšanju i stabilizaciji kvalitete sira. Praćenjem kemijskog i mikrobiološkog sastava mlijeka, kemijskog sas­ tava sirutke, praćenjem kemijske, mikrobiološke i organoleptičke kvalitete i randmana sira, te statističkom obradom rezultata analiza, utvrđeno je: da ke­ mijski sastav sira 'Podravca* odgovara sastavu naših ostalih polutvrdih sireva, da je povoljan randman sira posljedica sastava mlijeka i zrenja sira u plastičnoj foliji, te da se razlikuje randman sira proizvedenog ljeti i zimi, da mikrobiološka kvaliteta sira ne zadovoljava, da je organoleptička kvaliteta tog sira osrednja, što je posljedica mirkobiološke kvalitete sirovog i pasterizi­ ranog mlijeka, te zrenja sira. Rezultati istraživanja temelj su prijedloga osnovnih podataka za stan­ dard i definiciju sira »Podravca*. ^
Optimal Dispatching Strategy for Hybrid Microgrid with Small DC Charging Piles Based on V2G Technology

Large-scale integration of electric vehicles into the grid will have an impact on the grid and endanger the safe operation of the grid. This paper studies the optimal dispatching strategy for hybrid microgrid with small DC charging piles based on V2G technology. Firstly, establish an optimized dispatch model with the goal of minimizing user-side costs, network loss costs, wind and light abandonment costs, and load fluctuation costs. Consider the mobile energy storage characteristics of electric vehicles and determine the user’s charging method based on charging urgency. Secondly, based on the improved second-order cone relaxation algorithm, the established optimal scheduling model is solved using absolute value linearization and product variable linearization. Finally, the effectiveness of the proposed scheduling strategy is demonstrated through simulation in an improved IEEE 33-node AC and DC microgrid topology example.
Simulation and projection of climatic changes in the Indus River Basin, using the regional climate model COSMO‐CLM

In this article, the analysis of simulated and projected climatic changes in the Indus River Basin (IRB) is presented. The performance of the regional climate model COSMO‐CLM (CCLM) driven by the global circulation model MPI‐ESM‐LR is evaluated on the ability of reproducing temperature, precipitation, and wind pattern for the period 1961–2005. There exist quantitative biases, especially in precipitation pattern, which are associated to the diverse reproduction of the atmospheric circulation by the global circulation model. The overall results show that CCLM is able to satisfyingly capture the dominant spatial characteristics in annual temperature and precipitation time series, including the warming trend, and the seasonal variations.
Lactoferrin in the Prevention of Recurrent Respiratory Infections in Preschool Children: A Prospective Randomized Study

Few studies have evaluated the effect of bovine lactoferrin (bLf) on reducing respiratory infections in preschool children. This randomized controlled trial evaluated the effect of bLf in preschool children with recurrent respiratory infections. Participants were randomly assigned bLf (n = 25) or control (n = 25). Outcomes included respiratory infection episodes (RIEs), symptom duration, school absence and medication. Fifty children aged 4.2 ± 0.1 years were included. During the active 4-month phase, median number of RIEs was reduced by 50% in the bLf group [1-episode, interquartile range (IQR): 0–2] vs. control (2, IQR: 1–3; p = 0.02). The proportion of participants with >3 RIEs was significantly lower in bLf (n = 1, 4%) vs. control (n = 7, 28%) with 80% lower odds of upper RIEs in the bLf arm (odds ratio: 0.20, 95% CI:0.06–0.74, p = 0.015). The duration of symptoms (3 vs. 6, p = 0.009) and days absent from school (3 vs. 6, p = 0.15) were lower in the active arm. Over the 2-month follow-up, no significant differences were observed between groups for infection episodes, symptom duration or school absence. However, bLf-treated children received significantly less corticosteroids over the entire 6-month study period (32% vs. 60%; p = 0.047). bLf supplementation significantly reduced the frequency and duration of RIEs in children with decreased corticosteroid use.
Study on an intense dust storm over Greece

abstract Springtime constitutes the most favorable period for Sahara dust outbreaks and transportover Eastern Mediterranean. This study investigates the aerosol properties during April2005 using remote-sensing and ground-based measurements. Three dust events withhigh aerosol optical depth (AOD) values have been observed during the measuring period,with duration of two days, i.e.11–12,16–17 and 25–26 April 2005. In this paper we mainlyfocus on the intense dust event of 16–17 April 2005, when a thick dust layer transportedfrom Libya affected the whole Greek territory. Very high AOD values obtained from Aqua-MODIS sensor were observed over Greece (mean 2.42 1.25) on 17 April, while the respec-tive mean April value was 0.31 0.09. The AOD at 550 nm (AOD 550 ) values over Crete wereeven larger, reaching w4.0. As a consequence, the PM 10 concentrations over Athensdramatically increased reaching up to 200 m gm 3 . On the other hand, the ﬁne-modefraction values obtained from Terra-MODIS showed a substantial decrease in the wholeGreek area on 17 April with values below 0.2 in the Southern regions. The intense dustlayer showed a complex behavior concerning its spatial and temporal evolution andallowed us to study the changes in the optical properties of the desert dust particles alongtheir transport routes due to the mixing processes with other aerosol types. The resultsfrom different measurements (ground-based and remote-sensing) did not contradicteach other and, therefore, are adequate for monitoring of dust load over the EasternMediterranean. 2008 Elsevier Ltd. All rights reserved.
The impact of multi-species bacteria as a probiotic on productive performance and egg quality of laying Japanese quail

This study investigated the effect of individual and/ or a mixture multi-species bacteria as a probiotic (Pediococcus acidilactici (T1), Enterococcus faecium (m74) + Pediococcus acidilactici (T2), and Bacillus licheniformis + B. subtilis (T3)) supplementation at different levels on productive performance and egg quality characteristics in laying Japanese quail. At 42 d, 350 chicks were chosen with nearly similar live body weight and divided into ten groups of 35 chicks/group. Chicks were fed the basal diet as a control group (L0) or basal diet supplemented with three levels L1 (1.25), L2 (1.75), and L3 (2.25) g/kg diet, respectively. The bacteria-supplemented diets (T1 and T2) had an average feed intake that was the lowest and similar to control group. Better feed conversion was obtained in T1 birds in the first and third month and in the second month in T2. Age at sexual maturity was gradually decreased by dietary supplementation of T3 and L1. Probiotics increased egg production (EP) and egg mass (EM). EP, egg weight (EW), and EM increased gradually due to T3 and L2 supplementation. Bacteria-supplemented diets markedly increased absolute albumen and yolk weight as well as absolute and relative eggshell weight. In conclusion, the mixture of E. faecium (m74) + P. acidilactici and B. licheniformis + B. subtilis improved feed conversion ratio (FCR), egg production, and egg quality traits of laying Japanese quail.
Altered Liver Biochemistry and Mortality in Patients Hospitalized With COVID-19

COVID-19 is an illness caused by the SARS-CoV-2 virus, a type of coronavirus initially identified in China in late 2019, emerging as the leading cause of death attributed to a single infectious agent worldwide. The COVID-19 pandemic poses a substantial challenge to global public health in the first quarter of this century. The rapid evolution of the pandemic and its intricate response have hindered the formulation of definitive conclusions, and it may take years to comprehend its long-term effects. Assessing the extent of organ damage beyond the lungs could guide physicians in the disease's severity or progression. Based on these characteristics, an earlier and more targeted approach can be initiated at the appropriate moment. The association between hepatic profile and mortality in COVID-19 patients is a subject of scientific interest, as SARS-CoV-2 infection can lead to hepatitis. In severe cases, it may induce sepsis-related liver injury, potentially culminating in hepatic failure. Methodology: The study's objective is to determine the prevalence of mortality in adult patients with elevated hepatic profile hospitalized due to SARS-CoV-2 infection. This cross-sectional, monocentric study was conducted at a healthcare institution in Bogotá, Colombia. Results: This study includes 91 patients with confirmed diagnoses of COVID-19, revealing a prevalence of hepatic profile alterations in 61.5% (n=56) of hospitalized patients. The mortality rate observed is 17.6% (n= 16), with an odds ratio (OR) of 12.4 (95% CI = 1.56-99.0) in patients with hepatic profile alterations. Conclusions: This research underscores the importance of early detection of hepatic profile alterations in hospitalized patients with COVID-19. Not only are these alterations prevalent, but they are also potentially associated with an increased risk of mortality. These findings emphasize the necessity for further research to enhance strategies and prognostication for patients with COVID-19 in the future.
Common Resources Management and the "Dark Side" of Collective Action: an Impact Evaluation for Madagascar’s Forests

A sufficient level of collective action between community members is often presented as a strong pre-requisite to sustainably governing local common property resources(CPR). What if in some contexts instead, strong collective action led to short-term depletion of CPR instead of their sustainable use? This paper brings to light causal evidence on the environmental impact of establishing community-managed forests in Madagascar and highlights the complexities underlying collective action in their sustainable management. I compile fine-scale deforestation data over 15 years, use a unique spatial census of locally managed CPR and mobilize firsthand field data from four case studies to show that transferring management rights to local communities has failed to decrease deforestation. Instead, the policy has led to an increase in deforestation in some areas, often when collective action was strong, not when it was weak. This is what I call the possible "dark side" of collective action.
Effect of a probiotic blend in broiler chicken diets and its effect on growth performance, carcass traits, and haematological profile

The study aimed to assess the effect of different dietary levels of a probiotic blend (Probio Enzyme®) during the first 14 days of age (DOA) or up to 42 DOA, on growth performance, carcass and digestive tract traits, and haematological profiles of broiler chicks. A total of 540, one-day-old broiler chicks were randomized assigned to nine treatments: four dietary probiotic blend levels (250, 500, 750, and 1,000 g/ton) within two feeding periods (0–14 and 0–42 d, respectively), whereas the ninth treatment was a control diet without any dietary probiotic supplementation. The feed intake (FI) was found to be higher in broilers fed 1,000 g/ton of probiotic blend when fed during the first 14 d; however, BW gain and feed efficiency were not influenced by the treatments. Carcasses (deplumed and full) from broilers fed 250 g/ton of probiotic blend (0–14 DOA) were heavier than the other groups; the same was observed for leg portions. Broiler duodenum, jejunum and ileum weights, and ileum percentage were greater when fed diets without any supplementation. The haematological profile of broilers was not affected by the dietary treatments.
Sleep, inflammation, and hemodynamics in rodent models of traumatic brain injury

Traumatic brain injury (TBI) can induce dysregulation of sleep. Sleep disturbances include hypersomnia and hyposomnia, sleep fragmentation, difficulty falling asleep, and altered electroencephalograms. TBI results in inflammation and altered hemodynamics, such as changes in blood brain barrier permeability and cerebral blood flow. Both inflammation and altered hemodynamics, which are known sleep regulators, contribute to sleep impairments post-TBI. TBIs are heterogenous in cause and biomechanics, which leads to different molecular and symptomatic outcomes. Animal models of TBI have been developed to model the heterogeneity of TBIs observed in the clinic. This review discusses the intricate relationship between sleep, inflammation, and hemodynamics in pre-clinical rodent models of TBI.
Human Cytomegalovirus (HCMV) Genetic Diversity, Drug Resistance Testing and Prevalence of the Resistance Mutations: A Literature Review

Human cytomegalovirus (HCMV) is a pathogen with high prevalence in the general population that is responsible for high morbidity and mortality in immunocompromised individuals and newborns, while remaining mainly asymptomatic in healthy individuals. The HCMV genome is 236,000 nucleotides long and encodes approximately 200 genes in more than 170 open reading frames, with the highest rate of genetic polymorphisms occurring in the envelope glycoproteins. HCMV infection is treated with antiviral drugs such as ganciclovir, valganciclovir, cidofovir, foscarnet, letermovir and maribavir targeting viral enzymes, DNA polymerase, kinase and the terminase complex. One of the obstacles to successful therapy is the emergence of drug resistance, which can be tested phenotypically or by genotyping using Sanger sequencing, which is a widely available but less sensitive method, or next-generation sequencing performed in samples with a lower viral load to detect minority variants, those representing approximately 1% of the population. The prevalence of drug resistance depends on the population tested, as well as the drug, and ranges from no mutations detected to up to almost 50%. A high prevalence of resistance emphasizes the importance of testing the patient whenever resistance is suspected, which requires the development of more sensitive and rapid tests while also highlighting the need for alternative therapeutic targets, strategies and the development of an effective vaccine.
Assessment of Seasonal Variations of Surface Water Quality in the Phong Watershed, Thailand

Variations of water quality parameters with seasonal changes in the Phong watershed were explored. Water quality parameters including turbidity, suspended solids (SS), total dissolved solids (TDS), nitrate, phosphate, alkalinity, conductivity and total coliform were directly measured on site or analyzed at a laboratory twice a year in January (dry season) and in July ( wet season) for two years (2004 and 2005). The results revealed a significant influence of seasonal changes on the Phong water quality. It was significantly evident for the concentrations of turbidity, SS, NO:- and POe'- between wet and dry seasons. In addition, the water turbidity had strong positive correlations with SS and Phosphate (POot ), especially during the wet season in both the upstream and downstream of the Phong watershed where human activities have a high influence on land use patterns. While the middle Phong watershed, a location of the Ubolratana Dam, turbidity had very weak correlation with SS (0.14) in the dry season. However, it had very strong correlation with SS (1.00) in the wet season indicating that the dam plays an important role of settling down SS. Moreover, the significant positive correlations of turbidity, SS and POa3- especially in the wet season clearly indicated the phenomena of naturally occurred soil erosion with exacerbation by human induced soil erosion. This results in transformation of the forest land to the agricultural land which has been occupied in the Phong watershed. Therefore, these water quality parameters (turbidity, SS and PO4'-) should be focused on for monitoring human impacts on water quality in the Phong watershed.
Exosome-Delivered EGFR Induced by Acidic Bile Salts Regulates Macrophage M2 Polarization to Promote Esophageal Adenocarcinoma Cell Proliferation

Purpose Chronic gastroesophageal reflux disease (GERD) causes the abnormal reflux of acid and bile salts, which would induce Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). EGFR, as one of main components of the exosome, plays an important role in cancer progression. Here, we investigated the role of acidic bile salts (ABS)-induced exosomal EGFR in EAC cell proliferation. Methods Electronic microscopic examination and Western blot were used to identify exosomes. Western blot, siRNA transfection, enzyme-linked immunosorbent assay, qRT-PCR, cell viability detection, mouse xenograft tumor models, and immunohistochemical staining were performed to study the function of ABS-induced exosomal EGFR in cell proliferation. Results We found that ABS improved the exosomal EGFR level of normal human esophageal epithelial cells, BE cells, and BE-associated adenocarcinoma cells. The results were confirmed in the serum-derived exosomes from healthy persons and patients suffering from GERD, BE with or without GERD, and EAC with or without GERD. Moreover, cell line-derived exosomal EGFR was found to promote macrophage M2 polarization through the PI3K-AKT pathway. The co-incubation medium of macrophages and exosomes improved cell proliferation and tumor growth, which depended on the exosomal EGFR level. CCL18 was identified as the most effective component of the co-incubation medium to promote EAC cell proliferation by binding to its receptor PITPNM3 in vitro and in vivo. Conclusion Our findings demonstrate that ABS-induced exosomal EGFR regulates macrophage M2 polarization to promote EAC proliferation. This study provides an important insight into the role of ABS in EAC development.
Assessment of Nile crocodile utilization (Crocodylus niloticus) in Dunukofia Local Government Area, Anambra State, Nigeria

Assessment of Nile Crocodile utilization was carried out in six communities of Dunukofia local government area in Anambra state. A sampling intensity of 0.5% of the total population of each community was used to get a sample size of 323 respondents. Data were collected through questionnaire and complemented with personal observation and in-depth interview. The data collected were analyzed using descriptive statistics such as frequency, percentage and mean and presented as tables and charts. Results revealed that 85.14% of the respondents do not utilize crocodile meat as food while 14.86% of the respondents utilize crocodile meat as food. The highest number of respondents (66.67%) eat crocodile meat because of its taste while the least number (2.08%) because it is cheap. Results on non-consumptive utilization of Nile crocodile revealed that highest number of respondents (43.65%) utilize crocodile for traditional medicine while the least number (6.19%) reported that crocodile is utilized for tourism. The result also revealed that the sources of crocodile are the river (68.42%), markets (28.17%), and hunters (3.41%). A high percentage of the respondents (88.50%) are not interested in starting crocodile farming while 11.50% of the respondents are interested in starting crocodile farming. Majority of the respondents (65.73%) are not interested in starting crocodile farming because crocodiles are dangerous, 21.68% do not have the skills, 7.34% said crocodile farming is not popular and the least (5.24%) reported that it is high capital. Crocodile body parts utilized as revealed by the respondents were the whole body (53.56%), the head (30.03%), the limbs (10.84%), and the tail (5.57%). It is recommended that the locals be encouraged to engage in crocodile farming to help conserve the remaining crocodile population in the wild as well as create employment opportunities.
Need of belonging, Mexican men's normative socialization, and machismo as the root of couple problems, the role of alcohol use, and intimate partner violence

This research aims to understand and describe the etiology and mechanisms that maintain the association between alcohol consumption and violence perpetrated by Mexican men against their female partners. An exploratory qualitative study was conducted using the focus group technique, with the participation of 14 men recruited through a marketing campaign in social networks, all with a history of intimate partner violence and alcohol consumption (assessed using the AUDIT and a semi-structured questionnaire). The data analysis was done manually, based on grounded theory, and subjected to three triangulation types. According to the results, the etiology of the association between alcohol consumption and intimate partner violence is the inadequate satisfaction of the need for bonding (attachment), imposed by the normative socialization of being a man, culturally known as machismo; an association that is maintained mainly by emotional dysregulation, lack of cohabitation skills in couples and poor management of the family economy. The results bring to the table a well-known, but little-considered fact: both alcohol consumption and the exercise of violence are strongly influenced by culture, which makes it necessary to investigate the phenomenon, emphasizing the peculiarities of the population under study. These results can be considered an indicator of the components necessary to develop an intervention that addresses both variables in the Mexican population