Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of a novel cell cycle-related risk signature predicting prognosis in patients with pancreatic adenocarcinoma

Background: Growing evidence have indicated that cell cycle-related genes (CRGs) play an essential role in the progression of pancreatic adenocarcinoma (PAAD). Nevertheless, the application of CRGs in estimating the prognosis of PAAD patients is still lacking. This study aimed to establish a risk signature based on CRGs that can predict patients’ overall survival for PAAD. Methods: The expression and corresponding clinical data of PAAD patients from The Cancer Genome Atlas database and 200 cell cycle-related genes from the MSigDB were used for the generation and validation of the signature. LASSO Cox regression was applied to build the prediction model. The diagnostic value of signature was evaluated by receiver operating characteristic curves. Univariate and multivariate regression was used to construct the nomogram providing the clinicians a useful tool. Results: A total of 103 CRGs were identified. Seven genes (RBM14, SMAD3, CENPA, KIF23, NUSAP1, INCENP, SMC4) with non-zero coefficients in LASSO analysis were used to construct the prognostic signature. The 7-gene signature significantly stratified patients into high- and low-risk groups in terms of overall survival, and the area under the receiver operating characteristic curve of 5-year survival reached 0.749. Multivariate analysis showed that the signature is an independent prognostic factor. We then mapped a nomogram to predict 1-, 3-, and 5-year survival for PAAD patients. The calibration curves indicated that the model was reliable. Finally, we discovered that TP53 and KRAS mutated most frequently in low and high-risk groups, respectively. Conclusion: Our findings suggested that the seven genes identified in this study are valuable prognostic predictors for patients with PAAD. These findings provided us with a novel insight that it is useful for understanding cell cycle mechanisms and for identifying patients with PAAD with poor prognosis.
Acupuncture for shoulder-hand syndrome after stroke: An overview of systematic reviews

Background: To provide evidence, this review evaluated the methodological quality, risk of bias, and reporting quality of SRs/MAs in the treatment of shoulder-hand syndrome after stroke with acupuncture. Methods: Systematic reviews and Meta analyses (SRs/MAs) of acupuncture for shoulder and hand syndromes after stroke were retrieved from 6 databases from inception to May 1, 2022. Two reviewers independently screened the literature and extracted the data, then used Assessment of Multiple Systematic Reviews-2 (AMSTAR-2), Bias Risk in Systematic Review (ROBIS), and Preferred Report Item for Systematic review and Meta–analysis (PRISMA), Grading of Recommendations, Assessment, Development and Evaluation (GRADE) to assess methodological quality, risk of bias, quality of reporting, and quality of evidence. Results: We included 7 SRs/MAs, of which all SRs/MAs had very low AMSTAR-2 assessment quality and one study had a very low assessment bias risk. According to the PRISMA checklist, Protocol and registration, Synthesis of results, Summary of evidence, Conclusions and Funding were the main reporting limitations. GRADE evaluation showed a total of 37 results, but no high-quality evidence results, 6 results (16.22%) of the evidence quality were moderate, and supported acupuncture combined with exercise rehabilitation and drug therapy was better than exercise joint drug rehabilitation and rehabilitation, we also found that the result of limitations were the main factors that influence the evidence of low quality, followed by imprecision, inconsistency, and publication bias. Conclusions: Acupuncture is a relatively safe and effective adjuvant therapy for shoulder and hand syndromes after stroke. However, because of the low quality of SRs/MAs evidence supporting these findings, high-quality randomized controlled trials should be conducted, and the quality of relevant SRs should be improved to provide evidence for clinical application.
Two dimensional electron gas in the δ-doped iridates with strong spin–orbit coupling: LaδSr2IrO4

Iridates are of considerable current interest because of the strong spin–orbit coupling that leads to a variety of new phenomena. Using density-functional studies, we predict the formation of a spin-orbital entangled two dimensional electron gas (2DEG) in the -doped iridate LaSr2IrO4, where a single SrO layer is replaced by a LaO layer. The extra La electron resides close to the -doped layer, partially occupying the upper Hubbard band and thereby making the interface metallic. The magnetic structure of the bulk is destroyed near the interface, with the Ir0 layer closest to the interface becoming non-magnetic, while the next layer (Ir1) continues to maintain the AFM structure of the bulk, but with a reduced magnetic moment. The Fermi surface consists of a hole pocket and an electron pocket, located in two different Ir layers (Ir0 and Ir1), with both carriers derived from the upper Hubbard band. The presence of both electrons and holes at the -doped interface suggests unusual transport properties, leading to possible device applications.
Prognostic value of tumor size in thymic epithelial tumors: A systematic review and meta-analysis

Background: Whether the size of thymic epithelial tumors (TETs) has an impact on prognosis has long been a controversial issue. Our study was designed to investigate the value of tumor size in the prognosis (overall survival (OS) and relapse-free survival) of patients with TETs. Methods: We searched the databases such as PubMed, EMBASE, Web of Science, and clinical trials registration system for articles illustrating the impact of tumor size on survival data in TETs patients. We did a meta-analysis for OS and relapse-free survival. Results: We recruited 9 studies in our meta-analysis. Our study illustrates that TETs patients with small tumor size had better relapse-free survival (hazard ratio = 1.66, 95% confidence interval 1.18–2.35, P = .004) and OS (hazard ratio = 1.93, 95% confidence interval 1.30–2.80, P = .001) in comparison to patients with large tumor size. Conclusions: In conclusion, the results of our meta-analysis showed that TET size was significantly associated with overall and relapse-free survival of patients, with relatively small tumors tending to have a better prognosis.
Functional Meta-Optics and Nanophotonics Govern by Mie Resonances

Scattering of electromagnetic waves by subwavelength objects is accompanied by the excitation of electric and magnetic Mie resonances that may modify substantially the scattering intensity and radiation pattern. Scattered fields can be decomposed into electric and magnetic multipoles, and the magnetic multipoles define magnetic response of structured materials underpinning the new field of all-dielectric resonant meta-optics. Here we review the recent developments in meta-optics and nanophotonics and demonstrate that the Mie resonances can play a crucial role offering novel ways for the enhancement of many optical effects near magnetic and electric multipolar resonances, as well as driving a variety of interference phenomena which govern recently discovered novel effects in nanophotonics. We further discuss the frontiers of all-dielectric meta-optics for flexible and advanced control of light with full phase and amplitude engineering, including nonlinear nanophotonics, anapole nanolasers, quantum optics, .
Belief in Hard Work and Prosocial Behavior: Evidence from a Randomized Field Experiment ú

We provide evidence that optimistic beliefs regarding the malleability of ability, while leading to individual success, diminish the individual’s sympathy toward the unsuccessful. We generate random variation in beliefs via an educational intervention, which imparts to elementary school children the idea that ability, rather than being innately ﬁxed, can be developed through e � ort. To evaluate the impact of the intervention we create an experimental setting where both control and treatment students are given the opportunity to accumulate ability in a real e � ort task and earn rewards. Against this background, we implement an altruism experiment where we manipulate the donation context in terms of the potential reasons for the anonymous recipient’s poorness. We ﬁnd that while treated students are no less likely than control to give to recipients who are poor because of bad luck, they are signiﬁcantly less likely to give to those who failed at the task despite having had a chance to practice. The results point to the importance of beliefs about the role of hard work in shaping redistributive preferences. policymakers to improve non-cognitive skills starting from early education. Building an achievement mindset, praising e � ort rather than outcomes, and downplaying the role of innate ability to promote grit and tenacity are a major focus of such e � orts on the part of schools and families alike. Our results show that such policies, through changing the interpretation of what generates wealth, may have e � ects on the patterns of altruistic behavior as well. Given the literature that shows the equilibrium link between citizens’ worldviews and redistributive policies, these policies, if widely implemented, may have e � ects on the macroeconomy in the longer run.
The Mysterious 6565 Å Absorption Feature of the Galactic Halo

We consider various possible scenarios to explain the recent observation of what has been called a broad Hα absorption in our Galactic halo, with peak optical depth and equivalent width . We show that the absorbed feature cannot arise from the circumgalactic and ISM Hα absorption. As the observed absorption feature is quite broad ( ), we also consider CNO lines that lie close to Hα as possible alternatives to explain the feature. We show that such lines could also not account for the observed feature. Instead, we suggest that it could arise from diffuse interstellar bands (DIBs) carriers or polyaromatic hydrocarbons (PAHs) absorption. While we identify several such lines close to the Hα transition, we are unable to determine the molecule responsible for the observed feature, partly because of selection effects that prevent us from identifying DIBs/PAHs features close to Hα using local observations. Deep integration of a few extragalactic sources with high spectral resolution might allow us to distinguish between different possible explanations.
Corporate Image: A Service Recovery Perspective

This paper explores direct and indirect antecedents that contribute to corporate image formation in a service recovery context. Two studies were carried out in Egypt. Study 1 comprises 29 semi-structured interviews with complainants of mobile phone network service providers in Egypt. Study 2 encompasses a mail survey of another 437 complainants. Findings reveal the importance of perceived justice, namely interactional justice, in corporate image formation, as well as the mediating role of satisfaction with service recovery in the perceived justice–corporate image relationship. Results additionally reveal two empirical relationships: problem solving as a determinant of distributive justice and follow-up as a driver of procedural justice. Accordingly, this study contributes to the service field by providing the first empirical evaluation of new direct and indirect antecedents of corporate image formation in a service recovery context. Managerial recommendations are provided that encourage service practitioners to emphasize perceived justice and satisfaction with a service recovery process to enhance the company’s image. Additionally, companies should invest in implementing problem solving and follow-up as service recovery strategies since both significantly enhance perceived justice.
Nursing in the guidance about the self-care of patients in hemodialysis

Objective: to know the role of nursing in providing guidance about self-care for patients on hemodialysis. Method: descriptive qualitative study guided by Dorothea Orem's Theory of Self-care. Semi-structured interviews were conducted with 18 nursing professionals from a renal dialysis unit. Results: the analysis allowed the identification of two categories: self-care demands of hemodialysis patients and the role of nursing in providing guidance on the self-care of hemodialysis patients. Conclusion: it was possible to see that the nursing team recognizes and provides guidance on self-care. However, this action is still permeated by challenges due to the characteristics of the service itself, such as work overload and the difficulty of inserting guidance in an organized and systematized way in care protocols. Therefore, there is a clear need to encourage continuing education and to create of protocols and norms aimed at this action. de impulsar la formación permanente y la creación de protocolos y reglas dirigidas a esta acción.
Pressure-induced metal-insulator transition in twisted bilayer graphene

Recent experiments [arXiv: 1808.07865] on twisted bilayer graphene (TBLG) show that under hydrostatic pressure, an insulating state at quarter-filling of the moir\'e superlattice (i.e., one charge per supercell) emerges, in sharp contrast with the previous ambient pressure measurements of Cao et al. where the quarter--filling state (QFS) is a metal [Nature 556, 43 & 80 (2018)]. In fact, the insulating state at the other commensurate fillings of two and three charges per supercell is also enhanced under applied pressure. Based on realistic computations of the band structure for TBLG which show that the bandwidth first shrinks and then expands with increasing hydrostatic pressure, we compute the ratio of the potential to the kinetic energy, $r_s$. We find an experimentally relevant window of pressure for which $r_s$ crosses the threshold for a triangular Wigner crystal, thereby corroborating our previous work [Nano Lett. (2018)] that the insulating states in TBLG are due to Wigner rather than Mott physics. A key prediction of this work is that the window for the onset of the hierarchy of Wigner states that obtains at commensurate fillings is dome-shaped as a function of the applied pressure, which can be probed experimentally. Theoretically, we find a peak for crystallization around $1.5$ GPa relative to the experimental optimal pressure of $1.33$ GPa for the observation of the insulating states. Consequently, TBLG provides a new platform for the exploration of Wigner physics and its relationship with superconductivity.
Going nonlinear with dark energy cosmologies

We propose an efficient method for generating high accuracy ($\ensuremath{\sim}1%$) nonlinear power spectra for grids of dark energy cosmologies. Our prescription for matching matter growth automatically matches the main features of the cosmic microwave background (CMB) anisotropy power spectrum, thus naturally including ``CMB priors. ''
Spectral and Timing Properties of IGR J17091–3624 in the Rising Hard State During Its 2016 Outburst

We present a spectral and timing study of the NuSTAR and Swift observations of the black hole candidate IGR J17091–3624 in the hard state during its outburst in 2016. Disk reflection is detected in each of the NuSTAR spectra taken in three epochs. Fitting with relativistic reflection models reveals that the accretion disk is truncated during all epochs with , with the data favoring a low disk inclination of ∼30°–40°. The steepening of the continuum spectra between epochs is accompanied by a decrease in the high energy cutoff: the electron temperature drops from ∼64 to ∼26 keV, changing systematically with the source flux. We detect type-C QPOs in the power spectra with frequency varying between 0.131 and 0.327 Hz. In addition, a secondary peak is found in the power spectra centered at about 2.3 times the QPO frequency during all three epochs. The nature of this secondary frequency is uncertain; however, a non-harmonic origin is favored. We investigate the evolution of the timing and spectral properties during the rising phase of the outburst and discuss their physical implications.
F‐theory and Dark Energy

Motivated by its potential use as a starting point for solving various cosmological constant problems, we study F‐theory compactified on the warped product Rtime×S3×Y8 where Y8 is a Spin(7) manifold, and the S3 factor is the target space of an SU(2) Wess–Zumino–Witten (WZW) model at level N. Reduction to M‐theory exploits the abelian duality of this WZW model to an S3/ZN orbifold. In the large N limit, the untwisted sector is captured by 11D supergravity. The local dynamics of intersecting 7‐branes in the Spin(7) geometry is controlled by a Donaldson–Witten twisted gauge theory coupled to defects. At late times, the system is governed by a 1D quantum mechanics system with a ground state annihilated by two real supercharges, which in four dimensions would appear as “ N=1/2 supersymmetry” on a curved background. This leads to a cancellation of zero point energies in the 4D field theory but a split mass spectrum for superpartners of order Δm4D∼MIRMUV specified by the IR and UV cutoffs of the model. This is suggestively close to the TeV scale in some scenarios. The classical 4D geometry has an intrinsic instability which can produce either a collapsing or expanding Universe, the latter providing a promising starting point for a number of cosmological scenarios. The resulting 1D quantum mechanics in the time direction also provides an appealing starting point for a more detailed study of quantum cosmology.
Power spectrum of the Sunyaev-Zel’dovich effect

(Abridged) The hot gas in the IGM produces anisotropies in the Cosmic Microwave Background (CMB) through the thermal Sunyaev-Zel'dovich (SZ) effect. The SZ effect is a powerful probe of large-scale structure in the universe and must be carefully subtracted from measurements of the primary CMB anisotropies. We use moving-mesh hydrodynamical simulations to study the 3-dimensional statistics of the gas, and compute the mean comptonization parameter and the angular power spectrum of the SZ fluctuations, for different cosmologies. We compare these results with predictions using the Press-Schechter formalism. We find that the two methods agree approximately, but differ in details. We discuss this discrepancy, and show that resolution limits the reliability of our results to the 200<l<2000 range. For cluster- normalized CDM models, the SZ power spectrum is comparable to the primordial power spectrum around l=2000. We show that groups and filaments (kT<5 keV) contribute about 50% of the SZ power spectrum at l=500. About half of the SZ power spectrum on these scales is produced at redshifts z<0.1, and can thus be detected and removed using existing catalogs of galaxies and X-ray clusters. We discuss the implications of these results for the future MAP and Planck Surveyor missions.
The Mass Evolution of Protostellar Disks and Envelopes in the Perseus Molecular Cloud

In the standard picture for low-mass star formation, a dense molecular cloud undergoes gravitational collapse to form a protostellar system consisting of a new central star, a circumstellar disk, and a surrounding envelope of remaining material. The mass distribution of the system evolves as matter accretes from the large-scale envelope through the disk and onto the protostar. While this general picture is supported by simulations and indirect observational measurements, the specific timescales related to disk growth and envelope dissipation remain poorly constrained. In this paper we conduct a rigorous test of a method introduced by Jørgensen et al. to obtain mass measurements of disks and envelopes around embedded protostars with observations that do not resolve the disk (resolution of ∼1000 au). Using unresolved data from the recent Mass Assembly of Stellar Systems and their Evolution with the SMA (MASSES) survey, we derive disk and envelope mass estimates for 59 protostellar systems in the Perseus molecular cloud. We compare our results to independent disk mass measurements from the VLA Nascent Disk and Multiplicity survey and find a strong linear correlation, suggesting that accurate disk masses can be measured from unresolved observations. Then, leveraging the size of the MASSES sample, we find no significant trend in protostellar mass distribution as a function of age, as approximated from bolometric temperatures. These results may indicate that the disk mass of a protostar is set near the onset of the Class 0 protostellar stage and remains roughly constant throughout the Class I protostellar stage.
The ESO Multi-instrument Kinematic Survey (MIKiS) of Galactic Globular Clusters: Solid-body Rotation and Anomalous Velocity Dispersion Profile in NGC 5986

As part of the ESO-VLT Multi-Instrument Kinematic Survey of Galactic globular clusters (GCs), we present a detailed investigation of the internal kinematics of NGC 5986. The analysis is based on about 300 individual radial velocities of stars located at various distances from the cluster center, up to 300″ (about four half-mass radii). Our analysis reveals the presence of a solid-body rotation extending from the cluster center to the outermost regions probed by the data, and a velocity dispersion profile initially declining with the distance from the cluster’s center, but flattening and staying constant at ∼5 km s−1 for distances larger than about one half-mass radius. This is the first GC for which evidence of the joint presence of solid-body rotation and flattening in the outer velocity dispersion profile has been found. The combination of these two kinematical features provides a unique opportunity to shed light on fundamental aspects of GC dynamics and to probe the extent to which internal relaxation, star escape, angular momentum transport and loss, and the interaction with the Galaxy tidal field can affect a cluster’s dynamical evolution and determine its current kinematical properties. We present the results of a series of N-body simulations illustrating the possible dynamical paths leading to kinematic features like those observed in this cluster and the fundamental dynamical processes that underpin them.
HST-NICMOS Observations of M31's Metal Rich Globular Clusters and Their Surrounding Fields: I. Techniques

We have obtained HST-NICMOS observations of five of M31's most metal rich globular clusters. These data allow photometry of individual stars in the clusters and their surrounding fields. However, to achieve our goals -- obtain accurate luminosity functions to compare with their Galactic counterparts, determine metallicities from the slope of the giant branch, identify long period variables, and estimate ages from the AGB tip luminosity, we must be able to disentangle the true properties of the population from the observational effects associated with measurements made in very crowded fields. In this paper we present a careful analysis of photometry in crowded regions, and show how image blending affects the results and interpretation of such data. Although this analysis is specifically for our NICMOS observations in M31, the techniques we develop can be applied to any imaging data taken in crowded fields; we show how the effects of image blending will even limit NGST. We use three different techniques to analyze the effects of crowding on our data, including the insertion of artificial stars (traditional completeness tests) and the creation of completely artificial clusters. They are used to derive threshold- and critical-blending radii for each cluster, which determine how close to the cluster center reliable photometry can be achieved. The simulations also allow us to quantify and correct for the effects of blending on the slope and width of the RGB at different surface brightness levels.