Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Mechanisms of Endothelin-1–Induced Cell-Cycle Progression

Abstract—Although it is well established that endothelin-1 (ET-1) has not only vasoconstrictive effects but also mitogenic effects, which seem to be implicated in vascular remodeling, little is known about the molecular mechanisms by which ET-1 induces cell-cycle progression. In this study, we examined the effects of ET-1 on the cell-cycle regulatory machinery, including cyclins, cyclin-dependent kinase (cdk), and cdk inhibitors in NIH3T3 cells. ET-1 increased cyclin D1 protein (5.1±1.9-fold increase, 8 hours after stimulation, P<0.05), cdk4 kinase activity (2.8±0. 5-fold increase, 12 hours after stimulation, P<0.01), and cdk2 kinase activity (2.1±0.4-fold increase, 16 hours after stimulation, P<0.05) in a time- and dose-dependent manner. ET-1–induced increase in cyclin D1 protein, and cdk4 kinase activity was not significantly inhibited by an inhibitor of the mitogen-activated protein kinase kinase 1/2, PD98059, nor by the protein kinase C inhibitor calphostin C, whereas ET-1–induced upregulation of cycl.
Chickenpox Vaccination: Knowledge and Attitude of Child-Bearing Women of Abraka, Delta State, Nigeria

Chickenpox is a common childhood disease which is highly contagious. The World Health Organization (WHO) recommends that in countries where chickenpox is an important public health burden, chickenpox vaccination should be introduced into their routine immunization programs. This present study is to ascertain the level of knowledge and attitude towards chickenpox infection and its vaccination among child-bearing women in Abraka, Delta State, Nigeria. A cross-sectional descriptive study design was adopted to assess the knowledge and attitude towards chickenpox vaccination among 140 randomly selected child-bearing mothers residing in Abraka community. Of the 140 respondents, a greater number was within 30-40 years of age (61.4%). Most of the respondents (95.7%) had heard about chickenpox and 77.1% stated correctly its mode of transmitted.Majority were well aware of the signs and symptoms of the infection which included itching rashes (85.7%), blisters and red spots (66.4%), and fever (61.4%). Despite the fact that most of the respondents (72.9%) knew about chickenpox vaccination, only very few (19.3%) claimed to know the vaccine used, with less than half of the respondents (44.3%) correctly indicating two doses as the complete dosing for chickenpox vaccination. A greater proportion (91.4%) of the women had vaccinated their children against chickenpox, and believed that it was effective (82.1%). A high level of knowledge and positive attitude towards chickenpox vaccination among child-bearing women was evident in this study, however, it is paramount to encourage pregnant women and mothers attending antenatal care to immunize their children against vaccine-preventable diseases (VPDs). Keywords: Vaccination, chickenpox, vaccine-preventable diseases, knowledge, Abraka.
ON WHOSE AUTHORITY?

This study offers a preliminary investigation into a simulation-based, service-user-involved teaching model within a post-secondary child and youth care program. Using the method of collaborative self-study, this research draws on the diverse perspectives of six co-researchers, documenting our experience of this model through the lenses of student, professor, youth trainer, and facilitator. This study uses praxis (the cycle of action and reflection) and dialogic learning (learning through dialogue) to unpack personal and professional questions of expertise, participation, professional development, and anti-oppressive practice.
Clarity of task difficulty moderates the impact of the explicit achievement motive on physical effort in hand grip tasks

Stable personality dispositions, like motives, are often assumed to exert a direct, stable impact on behavior. This also applies to the explicit achievement motive, which is supposed to influence the behavior that individuals select and how strongly they engage in it. Drawing on motivational intensity theory, we demonstrated in two studies that explicit achievement motive strength only predicted exerted force in a hand grip task if task difficulty was unclear. If task difficulty was clear, explicit achievement motive strength did not influence exerted force. Our findings suggest that the availability of information about the difficulty of motive satisfaction moderates the impact of the explicit achievement motive on behavior.
Cardioprotective Effect of Quercetin in 5/6-Nephrectomized Rats: Focus on Myocardial fibrosis and Oxidative Stress

Uremic cardiomyopathy is the leading cause of death in patients with chronic kidney disease. Fluid overload and oxidative stress play important roles in its pathogenesis. This study aims to determine the effect of quercetin on uremic cardiomyopathy in 5/6-nephrectomized rats. To our knowledge, its cardioprotective effect on uremic cardiomyopathy induced in rats by 5/6 nephrectomy has not been investigated yet. Uremia was induced surgically in male Sprague-Dawley rats via 5/6 nephrectomy. Quercetin was administered per orally at a dose of 100 mg/kg/day for 8 weeks prior to sacrifice. Meanwhile, captopril was administered at a dose of 10 mg/kg/day. Lipid peroxidation was assessed using TBARS reaction, while GPX activity was determined to explore the endogen antioxidant mechanism. Myocardial fibrosis was analyzed using Massons’ Trichrome staining and the level of NT-proBNP in plasma was measured as a marker of cardiac dysfunction. Nephrectomy 5/6 had no effects on plasma NT– proBNP levels, cardiac and plasma MDA levels, but induced mild myocardial fibrosis and significant increase in cardiac GPX activity in comparison with normal rat (p<0.05). However, administration of quercetin or captopril did not ameleriote those mild myocardial fibrosis and increased GPX activity. Uremic cardiomyopathy induced by 5/6 nephrectomy demonstrated mild myocardial fibrosis but preservation of cardiac function demonstrated by NT-proBNP levels. Increased of GPX activity in the nephrectomized-rats compared to the control rats (p<0.05) suggests induction of antioxidant defense mechanisms that might not be exhausted yet. This condition highlighted a compensatory phase which was unchanged following chronic administration of either quercetin or captopril.
The Profitability of Businesses Owned by Nigerian Female Entrepreneurs: A Qualitative Analysis

This paper aim to assess the profitability of businesses owned by Nigerian female entrepreneurs. Assessing the past and current profitability, as well as projecting future profitability is imperative in the study of the post start-up phase of businesses. The paper adopts qualitative approach in order to assess the profitability of businesses owned by the female entrepreneurs. Interview was selected to serve as a research instrument in this study. The data collected were analysed using a thematic method. The paper found that female entrepreneurs express concern about poor tax administration and excessively complex tax regulations. The paper recommends a need to consider single taxes for small and medium scale businesses as a solution to reducing the incidence of paying multiple tax.
Drained‐to‐undrained transition of bulk modulus in fluid‐saturated porous rock induced by dead volume variation

We examine the effect of poroelastic boundary conditions when determining elastic properties of fluid‐saturated porous rocks from forced‐oscillation laboratory experiments. One undesired yet often unavoidable complication in the estimation of the undrained bulk modulus is due to the presence of the so‐called dead volume. It implies that some fluid mass can escape the rock sample under applying a confining pressure perturbation. Thus, the dead volume compromises the undrained state required to unambiguously determine the undrained bulk modulus. In this paper, we model data of recently performed low‐frequency (0.1 Hz) measurements. Therein, the dead volume has been systematically varied from 10% to 1000% of the pore volume. For the smallest dead volume, the inferred bulk modulus is close to the Biot–Gassmann undrained bulk modulus. With increasing dead volume, the experimentally inferred bulk modulus approaches the drained bulk modulus. We show that the transition from undrained to drained state as a function of dead volume can be modelled with a 1D poroelastic model for the rock sample‐dead volume system with a boundary condition that honours the continuity of the fluid volume flux. We discuss the limitations of the 1D model when applied to data recorded at higher frequencies (up to 100 Hz).
The role of technology readiness in individuals' intention to use health and fitness applications: a comparison between users and non-users

PurposeThe purpose of this study is to examine individuals' decisions to use health and fitness apps by applying the extended technology readiness and acceptance model (TRAM), which combines technology readiness (TR), the technology acceptance model (TAM) and perceived enjoyment (PEN). Moreover, this study explores the differences between users and non-users regarding their intentions to use health and fitness apps.Design/methodology/approachData collection (n = 206) was conducted using convenience sampling from four large universities in South Korea. The data were analysed by partial least squares structural equation modelling (PLS-SEM) using SmartPLS 3.0. FindingsThe results revealed that positive TR positively affects perceived ease of use (PEOU), perceived usefulness (PU) and PEN, while negative TR had a negative impact only on PEN. Furthermore, the significant relationships between PEOU, PU and PEN were identified. In addition, multigroup analyses indicated that the relationships between positive TR and PEN, between PEN and PEOU, between PEOU and PU, and between PU and behavioural intention were positively stronger for app users.Originality/valueThis study initially applied the TRAM to understand individuals' behavioural intentions to use health and fitness apps. Moreover, this study identified the distinct roles of positive and negative TR affecting individuals' cognition regarding using health and fitness apps. The differences in the psychological processes between app users and non-users offer insights and implications for practitioners.
The Intention of Halal Certification by Micro Business

Only about 10% of all micro business in Indonesia have been halal certified. This study aims to understand the factors that can encourage these businesses to undertake a halal certification. Of the 30 respondents who have not yet applied for a halal certificate, this study found that halal awareness, halal knowledge, and challenges in obtaining certification do not affect intention. The businesses surveyed knew about and understood the process of halal certification, but this knowledge did not guarantee they would apply. Challenges were also not a barrier of halal certification. However, internal and external pressures – such as the desire to have standardized products, encouragement from government, and consumer expectations of halal products – do foster the intention to gain halal certification. This study concludes by demonstrating the importance of real encouragement and assistance to motivate businesses to obtain halal certification for their products. Keywords: Halal certification, intention.
Enhancement of electro-optical and dielectric parameters of a room temperature nematic liquid crystalline material by dispersing multi-walled carbon nanotubes

ABSTRACT We have prepared the composites of a room temperature nematic liquid crystal mixture by dispersing small fractions of Multi-Walled Carbon Nanotubes into its matrix. The electro-optical and dielectric properties of the prepared samples were investigated. The effect of Multi-Walled Carbon Nanotubes on various display parameters of host nematic liquid crystal mixture was observed. The variations in some of the display parameters like dielectric anisotropy, threshold voltage, splay elastic constant and activation energy have been observed for composite systems with respect to pure nematic liquid crystal mixture. Dispersion of Multi-Walled Carbon Nanotubes enhanced the nematic order of liquid crystal host, resulting in the improvement of dielectric and electro-optical parameters of studied composite systems. Graphical abstract
Rethinking the Income Inequality and Financial Development Nexus. A Study of Nine OECD Countries

Sustainable finance seeks to increase the contribution of finance to sustainable and inclusive growth. The global financial crisis of 2008 provoked the return of inequality in advanced countries to levels typical of a century ago. The aim of this paper is to empirically analyze the relationship between finance and income inequality for a group of nine OECD countries over the pre-crisis and post-crisis periods (2000–2015). The model proposed in this study simultaneously considers two explanatory variables for measuring financial depth (credit provision and capital markets) and a new multidimensional variable to measure the financial system’s resilience (a composite indicator), and conducts panel data analysis. The empirical results confirm that in terms of financial depth, the "too much finance hypothesis" holds. We also find that financial system’s resilience helps alleviate existing income inequality and that income inequality appears higher in liberal market economies than in coordinated economies. These results encourage policymakers to look beyond traditional public redistribution interventions and to pay attention to other financial variables related to the financialization process, the behavior of financial intermediaries, and the specific environment in which they operate.
Multi-Item Scale Development for Online Consumption Emotion Construct And Psychometric Evaluation for Relationship Marketing

Abstract The present study aims to develop a multi-item scale to measure the online consumption emotion (OCE) to facilitate understanding of relationship marketing. Qualitative and quantitative approaches were employed, and psychometric procedures were followed for the scale development. The initial pool of scale items was tested using EFA with SPSS (v. 21.0), and CFA with AMOS (v. 18.0) to confirm the dimensionality of OCE scale. The EFA results revealed that OCE is a five-dimensional construct which consisted of 39 items. The scale includes excitement, comfort, ecstasy, annoyance and romance. The adequacy of employing a categorical approach to assess online shoppers’ emotional experiences in terms of positive/negative responses is required for online relationship marketing orientation. The online consumption emotion scale can be used to understand individual’s online shopping behavior. The findings can help online marketers to envisage relationship marketing strategies to increase their retail customer base, retain customers, improve positive word-of-mouth, and to improve relationship marketing for long-term profitability.
PENGARUH EDUKASI PASAR MODAL TERHADAP PERSEPSI RISIKO DAN MINAT BERINVESTASI MASYARAKAT

The majority of our society is not yet aware of the benefits of investing. They emphasize more importance to support life now without understanding the future. In Indonesia, based on data as of December 2018, only around 1,617,367 million were approved as independent shareholders in the Indonesian Central Securities Depository. The ratio is not even up to 0.5 percent of the total population of Indonesia. Market information and market knowledge are the main things. Today many countries agree to investment plans that want to increase domestic and international investment. This study aims to reveal the effect of capital market education on risk perceptions and community investment interests. Researchers want to look at the factors that influence the interest of investing in the community who incidentally do not have experience in investing in the stock market capital. This study uses primary data that is a questionnaire collected from participants, using a quasi-experimental technique in which participants are people who take part in voluntary capital market school activities at the Indonesian Stock Exchange KP Denpasar. The method of processing data uses path analysis. The results of this study capital market education has a positive influence on people's perceptions of interest and investment interest. While the perception does not have an interest in the interests of investing in the community.
Cdc42 negatively regulates endocytosis during apical plasma membrane maintenance and development in mouse tubular organs in vivo

Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the salivary glands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis of the intercellular canaliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur. Depletion of Cdc42 in adult mice induced a significant expansion of the apical canaliculi, whereas depletion at late embryonic stages resulted in a complete inhibition of their post-natal formation. In addition, intravital subcellular microscopy revealed that reduced levels of Cdc42 affected membrane trafficking from and towards the plasma membrane, highlighting a novel role for Cdc42 in membrane remodeling through the negative regulation of selected endocytic pathways.
Transient elastography with controlled attenuation parameter (CAP) for diagnosis of moderate or severe steatosis in people with suspected non-alcoholic fatty liver disease

© 2020 The Cochrane Collaboration. This article [Turankova T, Blyuss O, Brazhnikov A, Svistunov A, Gurusamy KS, Pavlov CS. Transient elastography with controlled attenuation parameter (CAP) for diagnosis of moderate or severe steatosis in people with suspected non-alcoholic fatty liver disease (Protocol). Cochrane Database of Systematic Reviews 2020, Issue 7. Art. No.: CD013670. DOI: 10.1002/14651858.CD013670. ], has been published in final form at https://doi.org/10.1002/14651858.CD013670.
‘Regurgitation and reingestion’ (R/R) in great apes: a review of current knowledge

Research indicates that regurgitation and reingestion (R/R) is a relatively common behaviour in zoo‐housed great apes, with most studies to date carried out on Western lowland gorillas Gorilla gorilla gorilla and Chimpanzees Pan troglodytes. R/R is an abnormal behaviour because great apes are not anatomically adapted to regurgitate their food as part of their normal feeding processes, and because this behaviour has not been observed in members of the species living freely in the wild, in conditions that would allow a full behavioural range. In this article, an overview is given of the published literature on R/R in great apes, which suggests that this behaviour is probably multifactorial and may be linked to inappropriate feeding environments (e.g. in terms of nutritional composition of the diet and/or presentation of food), and possibly also social and other factors. A similar behaviour to R/R, known as rumination disorder, can occur in humans (another great ape species), in whom it is classified as a feeding and eating disorder, and there are potential consequences to people's physical health as a result of oral acid. There have been no known studies to date to identify whether or not similar health consequences can occur in non‐human great apes, but the regurgitant has been found to be significantly more acidic in gorillas than the food they ingested originally, meaning it is potentially injurious in non‐human great apes. There is much that is not yet known about R/R and how to reduce or eliminate it when it does occur. The research indicates that there are a range of factors involved and these can vary by individual animal. More research into this behaviour is clearly needed to ensure that zoos and sanctuaries are providing the best possible care for these animals, and some suggestions for future research directions are included in this review.
A study of inhibition in preschool children at risk of Developmental Language Disorder

Background: For many years, research and practice have noted the impact of the heterogeneous nature of Developmental Language Disorder (DLD also known as language impairment or specific language impairment) on diagnosis and assessment. Recent research suggests the disorder is not restricted to the language domain and against this background, the challenge for the practitioner is to provide accurate assessment and effective therapy. The speech and language therapist (SLT) aims to support the child and their carers to achieve the best outcomes. However, little is known about the experiences of the SLT in the assessment process, in contrast to other childhood disorders, yet their expertise is central in the assessment and diagnosis of children with language disorder. The overall aims of the research were; firstly, to understand the issues in the diagnosis and assessment of children with language impairment and to synthesize the knowledge of SLTs working directly with children in this field; secondly, to investigate whether executive function abilities (i.e. inhibition and prospective memory) may be impaired in children at risk of developing DLD in the preschool period and thirdly, to investigate whether executive function tests correlate with a test of nonword repetition suitable for use with bilingual children. Study 1 aimed to gain an in-depth understanding of the experiences of speech and language therapists involved in the assessment and diagnosis of children with DLD including the linguistic and nonlinguistic aspects of the disorder. Three focus groups were used to provide a credible and rich description of the experiences of SLTs involved in the assessment of DLD. The analysis of the data showed three main themes relating to the SLTs’ experience in assessment and diagnosis of DLD. These themes were the participants’ experiences of the barriers to early referral, factors in assessment and the concerns over continued future support. These findings informed the design of Study 2 which compared the inhibition abilities of typically developing preschool children, with monolingual preschool children and bilingual preschool children who had already been referred to specialist language units and were therefore classed as “at risk” of developing DLD. Three inhibition tasks were used (motor inhibition, verbal inhibition and self-control) along with a prospective memory task and a nonword repetition test. The results indicated that children deemed “at risk” of DLD performed significantly worse than typically developing children on all tasks. Correlational analysis revealed significant relationships between the nonword repetition test and inhibition in the typically developing group but different relationships were seen in the “at risk” groups. For the monolingual at risk group the association was with nonword repetition and verbal