Miracle-dz/UniFAR-FTUs huggingface dataset:
Two new triterpene glycosides from sea cucumber Holothuria nobilis

Objective Triterpene glycosides were expected to be isolated from the sea cucumber Holothuria nobilis.Methods The crude saponins of sea cucumber were desulfated with pyridine-dioxane(1∶1),the desulfated products were separated by multi-chromatography to afford two compounds.Results On the basis of chemical methods and spectral evidences,especially 2D NMR and ESI-MS technologies,these two compounds were identified as 3-O-(3-O-methyl-β-D-glucopyranosyl(1→3)-β-D-quinovopyranosyl(1→4)-β-D-quinovopyranosyl(1→2)-β-D-xylopyranosyl)-holosta-9-ene-3β,12α,17α,25β-tetraol(Ⅰ),named as nobiliside 1a;3-O-(3-O-methyl-β-D-glucopyranosyl(1→3)-β-D-xylopyranosyl(1→4)-β-D-quinovopyranosyl(1→2)-4′-O-sulfate-β-D-xylopyranosyl)-holosta-22,25-epoxy-9-ene-3β,12α,17α,25β-triol(Ⅱ),named as nobiliside 2a.Conclusion Two compounds are new triterpene glycosides.
Effect of Ce doping on the structural, transport and magnetic properties of Sr2IrO4 epitaxial films

Sr2IrO4 is predicted to be superconducting and has received extensive attention in the field of high-temperature superconducting. Bulk Sr2IrO4 can be converted to a metallic state by slight chemical doping. Here we studied the structure, morphology, transport and magnetism of (Sr1−x Ce x )2IrO4 (x= 0, 0.0125, 0.025, 0.05) epitaxial films grown on (LaAlO3)0.3(Sr2AlTaO6)0.35 substrates. Unlike the bulk Sr2IrO4 material, the doped Sr2IrO4 epitaxial film maintains a wide range of Mott variable-range hopping characteristics in transport. Meanwhile, the magnetic properties and Raman characteristic peaks of the doped films become weakened, and the degree of weakening is proportional to the doping concentration. These observations can be attributed to the localization caused by disorder after Ce doping and the presence of structural defects. The epitaxial strain may result in important differences between Sr2IrO4 epitaxial thin films and bulk single crystals.
Human resource professionals’ human and social capital in SMEs: small firm, big impact

Abstract HR professionals have been widely ignored in the Human Resource (HR) management literature pertaining to small and medium-sized enterprises (SME). Given that entrepreneurs may be reluctant to hire HR professionals, it is important to investigate the value that HR people may bring to an SME. Addressing this literature gap, our research draws on resource orchestration theory (ROT) to link the interaction between HR professionals’ human and social capital to firm performance via the use of high-performance work practices (HPWPs). Further, this relationship depends on the SME’s size: in small firms, the link is strengthened because HR professionals’ human and social capital is more likely to create a competitive advantage in a context of resource poverty. We test the research model among a sample of 174 Canadian SMEs with fewer than 250 employees. Our results show that HR professionals’ human and social capital is more closely related to firm performance through the adoption of HPWPs in small SMEs than in large ones. Overall, our study highlights the value that HR professionals bring to small SMEs and advocates for a greater presence of HR professionals in SMEs.
An Exploratory Study Examining Differences in Drug Court Graduation Rates for Black and White Women

This exploratory study examined factors potentially associated with graduation for White and Black female Drug Treatment Court participants. Multiple logistic regression models for predicting program graduation were employed using an administrative data set (N = 1,093). Race was significant in a combined model. Age, prior felonies, employment, and negative peer associations predicted graduation for White women, whereas negative peer associations was the only predictor of graduation for Black women. Consideration of other factors that are not typically collected through administrative screenings is needed to better understand the strains typically experienced by Black women in Drug Treatment Court.
Converged journalism: practices and influences in Pakistan

Based on the hierarchy of influences model, we explored journalists’ understanding and perceptions about media convergence in Pakistan’s media industry and its influence on journalistic practices and routines. In-depth interviews with Pakistani news practitioners revealed several challenges hindering the successful implementation of media convergence in Pakistan. These challenges included the lack of resources for incorporating digital technologies, the lack of financial incentives, and stringent journalistic work routines, we found that technology-induced routines have severely affected both the personal and the professional lives of media practitioners. The adoption of convergence in Pakistan has been largely based on economic and commercial concerns rather than attempts to improve the quality of media content. Overall, the work contributes to the media convergence literature by providing insights from an emerging non-Western media system.
An evaluation of the potential factors affecting lifetime reproductive success in salmonids

Lifetime reproductive success (LRS), the number of offspring produced over an organism's lifetime, is a fundamental component of Darwinian fitness. For taxa such as salmonids with multiple species of conservation concern, understanding the factors affecting LRS is critical for the development and implementation of successful conservation management practices. Here, we reviewed the published literature to synthesize factors affecting LRS in salmonids including significant effects of hatchery rearing, life history, and phenotypic variation, and behavioral and spawning interactions. Additionally, we found that LRS is affected by competitive behavior on the spawning grounds, genetic compatibility, local adaptation, and hybridization. Our review of existing literature revealed limitations of LRS studies, and we emphasize the following areas that warrant further attention in future research: (1) expanding the range of studies assessing LRS across different life‐history strategies, specifically accounting for distinct reproductive and migratory phenotypes; (2) broadening the variety of species represented in salmonid fitness studies; (3) constructing multigenerational pedigrees to track long‐term fitness effects; (4) conducting LRS studies that investigate the effects of aquatic stressors, such as anthropogenic effects, pathogens, environmental factors in both freshwater and marine environments, and assessing overall body condition, and (5) utilizing appropriate statistical approaches to determine the factors that explain the greatest variation in fitness and providing information regarding biological significance, power limitations, and potential sources of error in salmonid parentage studies. Overall, this review emphasizes that studies of LRS have profoundly advanced scientific understanding of salmonid fitness, but substantial challenges need to be overcome to assist with long‐term recovery of these keystone species in aquatic ecosystems.
Graph-Embedded Convolutional Neural Network for Image-Based EEG Emotion Recognition

Emotion recognition from electroencephalograph (EEG) signals has long been essential for affective computing. In this article, we evaluate EEG emotion recognition by converting EEG signals from multiple channels into images such that richer spatial information can be considered and the question of EEG-based emotion recognition can be converted into image recognition. To this end, we propose a novel method to generate continuous images from discrete EEG signals by introducing offset variables following a Gaussian distribution for each EEG channel to alleviate the biased electrode coordinates during image generation. In addition, a novel graph-embedded convolutional neural network (GECNN) method is proposed to combine the local convolutional neural network (CNN) features with global functional features to provide complementary emotion information. In GECNN, the attention mechanism is applied to extract more discriminative local features. Simultaneously, dynamical graph filtering explores the intrinsic relationships between different EEG regions. The local and global functional features are finally fused for emotion recognition. Extensive experiments in subject-dependent and subject-independent protocols are conducted to evaluate the performance of the proposed GECNN model on four datasets, i.e., SEED, SDEA, DREAMER, and MPED.
Alternating hemiplegia of childhood: evolution over time and mouse model corroboration

Abstract Alternating hemiplegia of childhood is a rare neurodevelopmental disorder caused by ATP1A3 mutations. Some evidence for disease progression exists, but there are few systematic analyses. Here, we evaluate alternating hemiplegia of childhood progression in humans and in the D801N knock-in alternating hemiplegia of childhood mouse, Mashlool, model. This study performed an ambidirectional (prospective and retrospective data) analysis of an alternating hemiplegia of childhood patient cohort (n = 42, age 10.24 ± 1.48 years) seen at one US centre. To investigate potential disease progression, we used linear mixed effects models incorporating early and subsequent visits, and Wilcoxon Signed Rank test comparing first and last visits. Potential early-life clinical predictors were determined via multivariable regression. We also compared EEG background at first encounter and at last follow-up. We then performed a retrospective confirmation study on a multicentre cohort of alternating hemiplegia of childhood patients from France (n = 52). To investigate disease progression in the Mashlool mouse, we performed behavioural testing on a cohort of Mashlool- mice at prepubescent and adult ages (n = 11). Results: US patients, over time, demonstrated mild worsening of non-paroxysmal disability index scores, but not of paroxysmal disability index scores. Increasing age was a predictor of worse scores: P < 0.0001 for the non-paroxysmal disability index, intellectual disability scale and gross motor scores. Earliest non-paroxysmal disability index score was a predictor of last visit non-paroxysmal disability index score (P = 0.022), and earliest intellectual disability score was a predictor of last intellectual disability score (P = 0.035). More patients with EEG background slowing were noted at last follow-up as compared to initial (P = 0.015). Similar worsening of disease with age was also noted in the French cohort: age was a significant predictor of non-paroxysmal disability index score (P = 0.001) and first and last non-paroxysmal disability index score scores significantly differed (P = 0.002). In animal studies, adult Mashlool mice had, as compared to younger Mashlool mice, (i) worse balance beam performance; (ii) wider base of support; (iii) higher severity of seizures and resultant mortality; and (iv) no increased predisposition to hemiplegic or dystonic spells. In conclusion, (i) non-paroxysmal alternating hemiplegia of childhood manifestations show, on average over time, progression associated with severity of early-life non-paroxysmal disability and age. (ii) Progression also occurs in Mashlool mice, confirming that ATP1A3 disease can lead to age-related worsening. (iii) Clinical findings provide a basis for counselling patients and for designing therapeutic trials. Animal findings confirm a mouse model for investigation of underlying mechanisms of disease progression, and are also consistent with known mechanisms of ATP1A3-related neurodegeneration.
Applying Talent Quality-Management System (TTQS) to Enhance Information Literacy, Learning Motivation, and Computational Thinking Competency of Nursing Undergraduates

In Taiwan, the Ministry of Education started promoting computational thinking (CT) and design skills in the programming curriculum in 2018 at all universities. CT, which has been widely discussed in the field of education, is the ability to solve problems that use computer science concepts. For students in non-information technology fields, such as nursing students, a curriculum that integrates nursing education and information literacy can bolster evidence-based practice, enhance professional development, and encourage lifelong learning. However, the programming courses were difficult for non-information learners to apprehend, given their lack of knowledge in programming, and had a low attrition rate. Therefore, it is necessary to establish a sustainable management system in the learning process. It is also important to support the interest and confidence of the nursing learner in the programming curriculum. In this study, a programming course for nursing students was completed. A talent quality-management system (TTQS) for this programming course was built and implemented. A technology acceptance model and learning attitude questionnaires were administered to investigate learners’ learning motivation and information literacy. Two nursing classes with 74 freshmen participated in the curriculum in the second semester of the 2020 academic year. The results showed that TTQS, which supports teachers in adjusting pedagogy in a timely manner, can enhance learners’ motivation and performance. In this programming course, nursing students can learn CT and information concepts and improve their learning motivation through the design of learner-centred and collaborative learning.
Replication in field ecology: Identifying challenges and proposing solutions

Field ecology has been included in a ‘replication crisis’ that extends across many scientific disciplines. However, the underlying concepts of replication, reproducibility and replicability are not always clearly distinguished, and complicate the identification of best practices. Furthermore, conducting experiments under the high variability of natural field conditions reduces the capacity for replication relative to other biological disciplines working under controlled conditions. Field ecologists are therefore facing a significant challenge in assessing the replicability of their research with implications for overall confidence in study outcomes. Through a review of the literature, we discuss several related aspects of experimental design that can enhance confidence in scientific outcomes. Specifically, we describe sample replication (repeat sample), within‐study replication (repeat experiment) and between‐study replication (repeat study) and how each can be used within field ecology. Since perfect between‐study replication (i.e. direct replication) is generally not possible in field ecology, we suggest more explicit use of conceptual replication would enhance confidence in scientific outcomes. However, such changes require cultural shifts in practice among all participants in the scientific enterprise. We suggest several tangible steps could be taken to improve confidence in ecological research: (a) increase the use of within‐study replication before publication, (b) increase replicability for aspects that we can control (e.g. pre‐register experiments, open data, publish code), (c) divest from novelty as the primary criterion for publication in leading ecological journals and invest in experimental design, (d) be sceptical of contradictory findings from studies testing similar research questions and (e) create a publishing environment that encourages more conceptual replication studies. We believe adopting these practices will increase the confidence in results for field ecology. There are critical obstacles that could prevent some scientists from increasing within‐study or between‐study replication, including short‐term funding mechanisms and the prospect of fewer publications. We suggest strategies to mitigate negative impacts to researchers, such as leading journals piloting new article categories and explicit mention of experimentally linked studies. We acknowledge that adopting greater replication in field ecology will require significant changes to cultural practices, but there are clear benefits for improving our confidence in science.
Effect of Melanomal Proteins on Sepia Melanin Assembly

Melanins are phenol-based pigments with the potential for widespread applications, including bioelectronics and tissue engineering. The concentration-dependent structural transition of sepia melanin in water is analyzed. This biopolymer at high concentration gives the well-known nanospheres, whereas sample dilution gives unforeseen nanofibres exhibiting the structural features of mature amyloid fibrils. We propose a mechanism of pigment self-assembly dependent on the interaction of residual melanosomal protein(s) with eumelanin heteropolymer. Our results contribute to understanding the peculiar physicochemical properties of this ubiquitous pigment.
Fresh perspectives on an established technique: Pulsed amplitude modulation chlorophyll a fluorescence

Abstract Pulsed amplitude modulation (PAM) chlorophyll a fluorescence provides information about photosynthetic energy transduction. When reliably measured, chlorophyll a fluorescence provides detailed information about critical in vivo photosynthetic processes. Such information has recently provided novel and critical insights into how the yield potential of crops can be improved and it is being used to understand remotely sensed fluorescence, which is termed solar‐induced fluorescence and will be solely measured by a satellite scheduled to be launched this year. While PAM chlorophyll a fluorometers measure fluorescence intensity per se, herein we articulate the axiomatic criteria by which instrumentally detected intensities can be assumed to assess fluorescence yield, a phenomenon quite different than fluorescence intensity and one that provides critical insight about how solar energy is variably partitioned into the biosphere. An integrated mathematical, phenomenological, and practical discussion of many useful chlorophyll a fluorescence parameters is presented. We draw attention to, and provide examples of, potential uncertainties that can result from incorrect methodological practices and potentially problematic instrumental design features. Fundamentals of fluorescence measurements are discussed, including the major assumptions underlying the signals and the methodological caveats about taking measurements during both dark‐ and light‐adapted conditions. Key fluorescence parameters are discussed in the context of recent applications under environmental stress. Nuanced information that can be gleaned from intra‐comparisons of fluorescence‐derived parameters and intercomparisons of fluorescence‐derived parameters with those based on other techniques is elucidated.
Increased virulence of Italian infectious hematopoietic necrosis virus (IHNV) associated with the emergence of new strains

Abstract Infectious hematopoietic necrosis virus (IHNV) is the causative agent of IHN triggering a systemic syndrome in salmonid fish. Although IHNV has always been associated with low levels of mortality in Italian trout farming industries, in the last years trout farmers have experienced severe disease outbreaks. However, the observed increasing virulence of IHNV is still based on empirical evidence due to the poor and often confounding information from the field. Virulence characterization of a selection of sixteen Italian isolates was performed through in vivo challenge of juvenile rainbow trout to confirm field evidence. The virulence of each strain was firstly described in terms of cumulative mortality and survival probability estimated by Kaplan–Meier curves. Furthermore, parametric survival models were applied to analyze the mortality rate profiles. Hence, it was possible to characterize the strain-specific mortality peaks and to relate their topology to virulence and mortality. Indeed, a positive correlation between maximum mortality probability and virulence was observed for all the strains. Results also indicate that more virulent is the strain, the earliest and narrowest is the mortality peak. Additionally, intra-host viral quantification determined in dead animals showed a significant correlation between viral replication and virulence. Whole-genome phylogeny conducted to determine whether there was a relation between virulence phenotype and IHNV genetics evidenced no clear clustering according to phenotype. Moreover, a root-to-tip analysis based on genetic distances and sampling date of Italian IHNV isolates highlighted a relevant temporal signal indicating an evolving nature of the virus, over time, with the more virulent strains being the more recent ones. This study provides the first systematic characterization of Italian IHNV’s virulence. Overall results confirm field data and point out an abrupt increase in IHNV virulence, with strains from 2015–2019 showing moderate to high virulence in rainbow trout. Further investigations are needed in order to extensively clarify the relation between evolution and virulence of IHNV and investigate the genetic determinants of virulence of this viral species in rainbow trout.
Exploring Factors Related to Goal Scoring Opportunities in Professional Football

ABSTRACT Purpose Outscoring opponents is the primary goal in football. To optimise goal scoring opportunities (GSOs), it is important to understand the preceding physical and tactical performance. This observational study explored whether running behaviour prior to GSOs related to the subsequent outcome (goal or no goal) or contextual factors. Methods Tracking data was collected from one professional team during its 2016/2017 season. Physical output was differentiated for attacking styles and analysed for attackers (taking shots) and defenders (trying to prevent shots). Results Counter attacks were found most effective, as outcomes improved with fewer defenders behind the ball (r=-0.27; p=0.03). Offensively, running behaviour in the minute prior to GSOs explained most variance and increased activities correlated with success (r=0.26; p=0.04). Moreover, decreased high-intensity distances covered during matches significantly correlated with favourable outcomes (r=-0.21; p=0.02). Finally, increased attacking effectiveness was found to relate to greater defensive covered distances (r=0.51; p<0.01). Discussion Running behaviour prior to GSOs was found to relate to the subsequent outcome. Specifically, space ahead of attackers, forcing defenders to cover more ground, was found to relate to GSO effectiveness. The running behaviour of attackers was found unrelated to previous activity, highlighting the significance of physical capacity and well-timed substitutions.
Effect of Work Engagement, Work Environment and Work Spirit on Teacher Satisfaction

This study aims in general to prove and analyze the effect of work involvement, work environment and work morale on teacher job satisfaction at SDN Aeng Beje Kenek. The population of this study were all permanent teachers at SDN Aeng Beje Kenek IV, Kecamatan Bluto recorded in mid-2013 with a total of 80 people. the following results are obtained: (1) The three independent variables, namely work involvement, work environment and morale have a significant positive effect on teacher job satisfaction at SDN Aeng Beje Kenek IV Kecamatan Bluto, thus proving that the three independent variables simultaneously have a significant effect on teacher job satisfaction. (2) Involvement work has a positive effect on teacher job satisfaction. The regression coefficient of 0.3677 shows, if there is an increase in work involvement by 1 point, it will increase teacher job satisfaction by 0.3677 points. Although it has a positive significant effect, job involvement has the smallest effect on teacher job. (3) The work environment in this study has a positive and nutritious effect on teacher job satisfaction. (4) Morale is the most effective and greatest in increasing job satisfaction of a teacher. Keywords: work involvement, work environment, Satisfaction