Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling population effects of the Deepwater Horizon oil spill on a long‐lived species

The 2010 Deepwater Horizon (DWH) oil spill exposed common bottlenose dolphins (Tursiops truncatus) in Barataria Bay, Louisiana to heavy oiling that caused increased mortality and chronic disease and impaired reproduction in surviving dolphins. We conducted photographic surveys and veterinary assessments in the decade following the spill. We assigned a prognostic score (good, fair, guarded, poor, or grave) for each dolphin to provide a single integrated indicator of overall health, and we examined temporal trends in prognostic scores. We used expert elicitation to quantify the implications of trends for the proportion of the dolphins that would recover within their lifetime. We integrated expert elicitation, along with other new information, in a population dynamics model to predict the effects of observed health trends on demography. We compared the resulting population trajectory with that predicted under baseline (no spill) conditions. Disease conditions persisted and have recently worsened in dolphins that were presumably exposed to DWH oil: 78% of those assessed in 2018 had a guarded, poor, or grave prognosis. Dolphins born after the spill were in better health. We estimated that the population declined by 45% (95% CI 14–74) relative to baseline and will take 35 years (95% CI 18–67) to recover to 95% of baseline numbers. The sum of annual differences between baseline and injured population sizes (i.e., the lost cetacean years) was 30,993 (95% CI 6607–94,148). The population is currently at a minimum point in its recovery trajectory and is vulnerable to emerging threats, including planned ecosystem restoration efforts that are likely to be detrimental to the dolphins’ survival. Our modeling framework demonstrates an approach for integrating different sources and types of data, highlights the utility of expert elicitation for indeterminable input parameters, and emphasizes the importance of considering and monitoring long‐term health of long‐lived species subject to environmental disasters.
A protocol for systematic review and meta-analysis

Background:Many studies have shown the effects of SGLT2 inhibitors on type 2 diabetes, but the effects in patients with type 2 diabetes with chronic kidney disease remains unclear. This study aims to evaluate the effects of SGLT2 inhibitors on renal outcomes in patients with type 2 diabetes mellitus with chronic kidney disease. Methods:We conducted systematic searches of PubMed, Embase, and Cochrane Central Register of Controlled Trials up to April 30, 2020 and included randomized controlled trials of SGLT2 inhibitors in adult type 2 diabetes mellitus (T2DM) patients with chronic kidney disease (CKD) reporting estimated glomerular filtration rate (eGFR) and/or urine albumin/creatinine ratio (UACR) changes and/ or acute kidney injury or failure (AKI). Random effects models were adopted to measure the pooled outcomes. Results:Nine studies with 8826 participants were included. SGLT2 inhibitors were not associatedwith a significant change in eGFR (mean difference (MD), 0.75ml/minutes per 1.73 m, 95% CI 1.61 to 0.10, P= . 09) in type 2 diabetic patients with CKD. UACR reduction after SGLT2 inhibitors was significant in type 2 diabetic patients with CKD (MD 24.27mg/g, 95% CI 44.46 to 4.09, P= .02). SGLT2 inhibitors associated with AKI in the patients were significant (OR 0.80, 95% CI [0.66 to 0.98], P= .03). Conclusion: SGLT2 inhibitors had no significant effect on kidney function (eGFR measured) in the pooled analysis. And SGLT2 inhibitors effectively reduced UACR in T2DM with CKD. Besides, SGLT2 inhibitors could reduce the incidence of AKI. Abbreviations: AKI = acute kidney injury or failure, CKD = chronic kidney disease, eGFR = estimated glomerular filtration rate, T2DM = type 2 diabetes mellitus, UACR = urine albumin/creatinine ratio.
Which factors influence the prevalence of institution‐acquired falls? Results from an international, multi‐center, cross‐sectional survey

Abstract Purpose Falls are a highly prevalent problem in hospitals and nursing homes with serious negative consequences such as injuries, increased care dependency, or even death. The aim of this study was to provide a comprehensive insight into institution‐acquired fall (IAF) prevalence and risk factors for IAF in a large sample of hospital patients and nursing home residents among five different countries. Design This study reports the outcome of a secondary data analysis of cross‐sectional data collected in Austria, Switzerland, the Netherlands, Turkey, and the United Kingdom in 2017 and 2018. These data include 58,319 datapoints from hospital patients and nursing home residents. Methods Descriptive statistics, statistical tests, logistic regression, and generalized estimating equation (GEE) models were used to analyze the data. Findings IAF prevalence in hospitals and nursing homes differed significantly between the countries. Turkey (7.7%) had the highest IAF prevalence rate for hospitals, and Switzerland (15.8%) had the highest IAF prevalence rate for nursing homes. In hospitals, our model revealed that IAF prevalence was associated with country, age, care dependency, number of medical diagnoses, surgery in the last two weeks, and fall history factors. In nursing homes, care dependency, diseases of the nervous system, and fall history were identified as significant risk factors for IAF prevalence. Conclusions This large‐scale study reveals that the most important IAF risk factor is an existing history of falls, independent of the setting. Whether a previous fall has occurred within the last 12 months is a simple question that should be included on every (nursing) assessment at the time of patient or resident admission. Our results guide the development of tailored prevention programs for persons at risk of falling in hospitals and nursing homes.
Refinement and Validation of the Hydraulic Fracture Test

The hydraulic fracture test was developed under the Strategic Highway Research Program to address the need for a more rapid, less expensive test for concrete aggregate freeze–thaw durability. Although the test concept appeared sound, the original test and analysis procedures were not sufficiently reliable and accurate to merit widespread adoption and implementation. Several follow-up research efforts have been performed, and each has resulted in improvements to the test. The results of the most recent study, which evaluated changes in both the test procedure (to include additional test sieves for better characterization of particle fractures) and the analysis procedures, are described. The “hydraulic fracture index” has been replaced by a model that predicts freeze–thaw test dilation as a function of the distribution of particle mass retained on the test sieves. This model was developed using data obtained from freeze–thaw and hydraulic fracture testing of 18 quarried carbonate and gravel aggregate sources; the resulting correlation is exceptional (r2 = 0.98). An additional improvement is the development of a large test chamber capable of handling aggregate samples five times larger than the original small chamber, which thereby allows aggregate durability characterization with a single test run. It is believed that the hydraulic fracture test is now ready for more broad-based validation testing and eventual widespread acceptance and implementation as an accurate screening tool for concrete aggregate freeze–thaw durability.
Observations of different types of sacra in Greyhounds based on the occurrence of sacrocaudal fusion

Little attention has been paid to the normal fusion of the vertebrae of greyhounds despite the common occurrence of sacrocaudal fusion. The current study aimed to investigate and provide data on the morphology of different types of fused sacra (B, C and D) in greyhounds and also to determine the potential association between the sex, body mass and morphology of fused sacra (S. Weight, S. Length and S. Width) in greyhounds. The sacra were collected from 171 greyhounds from Melbourne, Australia. After classifying the sacra based on the occurrence and types of the sacrocaudal fusion, they were measured for weight of the sacrum, length of sacrum and the width of sacrum. Multiple linear regression analyses were used to quantify the association between weight of the sacrum (as the outcome variable) type of sacrum (A, B, C and D), body mass and sex (as explanatory variables). The results proved that there are measurable differences between each type of fused sacra (B, C and D) and the standard sacra (A). In addition, this study showed that sex or body mass do not influence the occurrence of different types of fusion. The results of this study showed that the occurrence of sacrocaudal fusions was independent of body size in this population of greyhounds. Sacrocaudal fusion might affect the biomechanics in greyhounds independently of effects of body size.
Time trends and social inequalities in child malnutrition: nationwide estimates from Brazil’s food and nutrition surveillance system, 2009–2017

Abstract Objective: In Brazil, national estimates of childhood malnutrition have not been updated since 2006. The use of health information systems is an important complementary data source for analysing time trends on health and nutrition. This study aimed to examine temporal trends and socio-demographic inequalities in the prevalence of malnutrition in children attending primary health care services between 2009 and 2017. Design: Time trends study based on data from Brazil’s Food and Nutrition Surveillance System. Malnutrition prevalence (stunting, wasting, overweight and double burden) was annually estimated by socio-demographic variables. Prais–Winsten regression models were used to analyse time trends. Annual percent change (APC) and 95 % CI were calculated. Setting: Primary health care services, Brazil. Participants: Children under 5 years old. Results: In total, 15,239,753 children were included. An increase in the prevalence of overweight (APC = 3·4 %; P = 0·015) and a decline in the prevalence of wasting (–6·2 %; P = 0·002) were observed. The prevalence of stunting (–3·2 %, P = 0·359) and double burden (–1·4 %, P = 0·630) had discrete and non-significant reductions. Despite the significant reduction in the prevalence of undernutrition among children in the most vulnerable subgroups (black, conditional cash transfer’s recipients and residents of poorest and less developed areas), high prevalence of stunting and wasting persist alongside a disproportionate increase in the prevalence of overweight in these groups. Conclusions: The observed pattern in stunting (high and persistent prevalence) and increase in overweight elucidate setbacks in advances already observed in previous periods and stresses the need for social and political strategies to address multiple forms of malnutrition.
Phenotype and severity of asthma determines bronchial epithelial immune responses to a viral mimic

Background Asthma is characterised by an aggravated immune response to respiratory viral infections. This phenomenon is a clinically well-recognised driver of acute exacerbations, but how different phenotypes of asthma respond immunologically to viruses is unclear. Objectives To describe the association between different phenotypes and severity of asthma and bronchial epithelial immune responses to viral stimulation. Methods In the Immunoreact study, healthy subjects (n=10) and 50 patients with asthma were included; 30 (60%) were atopic, and 34 (68%) were eosinophilic; 14 (28%) had severe asthma. All participants underwent bronchoscopy with collection of bronchial brushings. Bronchial epithelial cells (BECs) were expanded and stimulated with the viral replication mimic poly (I:C) (Toll-like receptor (TLR)3 agonist) in vitro. The expression of TLR3-induced pro-inflammatory and antiviral responses of BECs were analysed using reverse transcriptase quantitative PCR and multiplex ELISA and compared across asthma phenotypes and severity of disease. Results Patients with atopic asthma had increased induction of interleukin (IL)-4, interferon (IFN)-β, IL-6, tumour necrosis factor-α, and IL-1β after poly (I:C) stimulation compared to non-atopic patients, whereas in patients with eosinophilic asthma only IL-6 and IL-8 induction was higher than in non-eosinophilic asthma. Patients with severe asthma displayed a decreased antiviral IFN-β, and increased expression of IL-8, most pronounced in atopic and eosinophilic asthmatics. Furthermore, induction of IL-33 in response to poly (I:C) was increased in severe atopic and in severe eosinophilic asthma, but thymic stromal lymphopoietin only in severe eosinophilic asthma. Conclusions The bronchial epithelial immune response to a viral mimic stimulation differs between asthma phenotypes and severities, which may be important to consider when targeting novel asthma treatments. The airway epithelial pro-inflammatory and anti-viral response to a viral stimulus differs with the phenotype and severity of asthma, indicating differences in immune drivers of exacerbations https://bit.ly/3DhTVWw
Learned temporal statistics guide information seeking and shape memory.

Curiosity drives information seeking and promotes learning. Prior work has focused on how curiosity is elicited by intrinsic qualities of information, leaving open questions about how curiosity, exploration, and learning are shaped by the environment. Here we examine how temporal dynamics of the learning environment shape curiosity and learning. Participants (n = 71) foraged for the answer to trivia questions in two conditions that differed only in their temporal statistics. In one condition, the timing of information delivery followed a uniform distribution, while in another it followed a heavy-tailed distribution. We found that the two conditions elicited distinct responses in both behavior and pupil dilation: participants were more likely to wait for information and to later remember it in the uniform distribution. By contrast, participants showed greater surprise, evidenced in a spike in pupil dilation, when presented with the answers in the heavy-tailed distribution. Furthermore, pupil dilation was inversely related to curiosity and memory, suggesting that temporal uncertainty may interfere with the positive effects of curiosity on learning. Our findings demonstrate that the predicted timing of information delivery influences information seeking, memory, and physiological arousal, suggesting that information is best learned when it is both intrinsically interesting and presented within a temporally predictable environment. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Sexuality Discourses and LGBQ Students’ Interpretations of Campus Climate in the Contemporary US

ABSTRACT Recent US studies showed that perceptions of campus climate vary considerably across individual LGBQ students, with some students reporting friendly climates and others reporting persistent hostility. Although researchers have identified several factors that contribute to the perceptual variations, they have paid limited attention to the role of sexuality discourses. The present study sought to fill this gap in the literature by analyzing in-depth interviews. The analysis showed that LGBQ students drew on two major discourses to guide their interpretations of campus climate. A majority of students drew on post-closet discourse to celebrate their visibility on campus, LGBQ-friendly courses, and straight classmates’ positive reactions. A smaller number of students drew on queer discourse to question the meaning of LGBQ students’ visibility and criticize heterosexist biases in classrooms. Overall, these results highlighted the importance of the competing discourses, which set LGBQ students’ expectations and guided their interpretations of campus experiences.
Differences in the sequence of PlcR transcriptional regulator–binding site affect sphingomyelinase production in Bacillus cereus

Bacillus cereus is an opportunistic pathogen that often causes severe infections such as bacteremia, with sphingomyelinase (SMase) being a crucial virulence factor. Although many strains of B. cereus carry the SMase gene, they are classified as SMase‐producing and nonproducing strains. The reason for different SMase production among B. cereus strains remains unknown. In this study, we investigated the relationship between SMase and the PlcR transcriptional regulation system to clarify the mechanism leading to varied SMase production among B. cereus strains. We analyzed the sequence of the PlcR box, which is a transcriptional regulator‐binding site, located at the promoter region of SMase and phosphatidylcholine‐specific phospholipase C. Based on differences in the PlcR box sequences, we classified the B. cereus strains into three groups (I, II, and III). SMase expression and activity were hardly detected in Group III strains. In Group I strains, SMase activity and its expression were maximal at the onset of the stationary phase and decreased during the stationary phase, whereas those were maintained during the stationary phase in Group II stains. On injection of B. cereus strains into mice or incubation with macrophages for phagocytosis assay, the SMase‐producing Group I and II strains showed higher pathogenicity than Group III strains. These findings suggest that PlcR box sequence in B. cereus affects the production of SMase, which may provide important clinical information for the detection of highly pathogenic B. cereus strains.
The Tangled Webs We Wreak: Examining the Structure of Aggressive Personality Using Psychometric Networks.

OBJECTIVE Trait aggression is a prominent construct in the psychological literature, yet little work has sought to situate trait aggression among broader frameworks of personality. Initial evidence suggests that trait aggression may be best couched within the nomological network of the Five Factor Model (FFM). The current work sought to locate the most appropriate home for trait aggression among the FFM. METHOD We applied a preregistered regimen of psychometric network analyses to three datasets (combined N = 2,927) that contained self-reports of trait aggression and the FFM traits. RESULTS Trait aggression was highly central in the factor-level networks, which contained associations consistent with the conceptualization of this construct as a lower-order component of low agreeableness. The facet-level networks revealed that the behavioral facets of trait aggression reflected low agreeableness, but that the anger and hostility facets reflected high neuroticism. The item-level network suggested that the intent to initiate aggressive encounters was the primary bridge that empirically linked trait aggression to agreeableness. CONCLUSIONS Our results indicate that trait aggression is primarily a lower-order facet of agreeableness, advance our understanding of trait aggression, integrate it with broader frameworks of personality, and suggest future directions to refine this complex dispositional tendency.
Efficacy and safety of traditional Chinese medicinal enemas for treatment of chronic renal failure

Abstract Background: Chronic renal failure (CRF) is a common kidney disease characterized by a slow and progressive decline in kidney function. Clinical practice suggests that traditional Chinese medicinal enemas have a therapeutic effect on CRF. To assess the therapeutic efficacy and safety of traditional Chinese medicinal enemas in treating CRF, we created a protocol for a systematic review to inform future clinical applications. Methods: We completed a literature search of all clinical randomized controlled trials evaluating traditional Chinese medicinal enemas on CRF in the following five English and four Chinese databases completed before August 2020: Medline, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Library database, Chinese National Knowledge Infrastructure (CNKI), WANFANE Database, Chinese Scientific and Technological Periodical Database (VIP) and Chinese Biomedical Database (CBM). The primary outcomes evaluated blood urea nitrogen levels, uric acid levels, endogenous creatinine clearance rate, and serum creatinine, and the secondary outcomes included clinical efficacy and adverse effects of treatment. Two independent researchers performed data extraction and quality assessment. RevMan5.3 software was used to assess data quality and bias. This protocol was conducted according to the Preferred Reporting Item for Systematic Review and Meta-analysis Protocol (PRISMA-P) statement. Results: This study will provide a rational synthesis of current evidence for traditional Chinese medicinal enemas for the treatment of CRF. Conclusion: This study presents evidence on whether traditional Chinese medicinal enemas are an effective and safe intervention for CRF patients. Registration number: INPLASY202080052
Recidivism Among the Customers of Female Street Prostitutes: Do Intervention Programs Help?

This study examines recidivism among offenders participating in a program designed to discourage re-offending among men arrested for trying to hire street prostitutes. Such programs now exist in San Francisco, California; Las Vegas, Nevada; and Pittsburgh, Pennsylvania, and are being developed in other cities nationwide. Though now defunct, Portland, Oregon’s Sexual Exploitation Education Project (SEEP), was one of the first of these programs. This study finds that the rate of recidivism among men participating in the Portland program was low. However, recidivism among men who did not participate in the program was also low. The findings suggest that recidivism may not be a useful measure of effectiveness for programs aimed at men arrested for trying to hire street prostitutes.
Characterization of patients with Becker muscular dystrophy by histology, magnetic resonance imaging, function, and strength assessments

Becker muscular dystrophy (BMD) is characterized by variable disease severity and progression, prompting the identification of biomarkers for clinical trials. We used data from an ongoing phase II study to provide a comprehensive characterization of a cohort of patients with BMD, and to assess correlations between histological and magnetic resonance imaging (MRI) markers with muscle function and strength.
Multiphase railgun systems: a new concept

The authors investigate multiphase railguns powered by multiphase compulsators. The polyphase system offers several advantages over the single-phase system. The multiphase compulsator relaxes the strong dependence between the current pulse width necessary for the railgun and the design parameters of the generator, thus allowing the compulsator to be designed for optimum power density and electromechanical energy conversion. The authors examine the two-, three-, and six-phase systems. They also explore different methods of achieving high acceleration ratios in multiphase railgun systems. Some of the methods analyzed are ramping up the field current of the compulsator to counter the back electromotive force of the gun, utilizing a railgun with varying inductance per unit length, and using an external variable inductor in series with the compulsator. The different features of each method are highlighted using simulation results. >