Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-Control, Parental Monitoring, and Adolescent Problematic Mobile Phone Use: Testing the Interactive Effect and Its Gender Differences

Previous studies have revealed that self-control was one of the critical factors of adolescent problematic mobile phone use. Few studies, however, have explored the interaction of internal control force (i.e., self-control) and external control force such as parental monitoring. The present study tested the interactive effect of self-control and parental monitoring on adolescent problematic mobile phone use and its gender differences. A sample of 926 adolescents completed our anonymous self-report survey. Results showed that self-control and parental monitoring negatively predicted problematic mobile phone use, while gender positively predicted problematic mobile phone use. Self-control and parental monitoring had an interactive effect on problematic mobile phone use, with the effect of self-control on problematic mobile phone use being stronger for adolescents with low levels of parental monitoring than for those with high levels of parental monitoring. Self-control and gender had an interactive effect on problematic mobile phone use, with the effect of self-control on adolescent problematic mobile phone use being stronger in girls than in boys. Moreover, there were significant gender differences in the interaction of self-control and parental monitoring, in that the interactive effect of self-control and parental monitoring on problematic mobile phone use was more potent in girls than in boys. The findings reveal how the internal control force (i.e., self-control) and external control force (i.e., parental monitoring) work together in explaining adolescent problematic mobile phone use and uncover the potential gender differences in exploring adolescent problematic mobile phone use from the individual-environment perspective. Limitations and implications are discussed.
Brief Research Report: Virus-Specific Humoral Immunity at Admission Predicts the Development of Respiratory Failure in Unvaccinated SARS-CoV-2 Patients

Introduction There is robust evidence indicating that the SARS-CoV-2-specific humoral response is associated with protection against severe disease. However, relatively little data exist regarding how the humoral immune response at the time of hospital admission correlates with disease severity in unimmunized patients. Our goal was toidentify variables of the humoral response that could potentially serve as prognostic markers for COVID-19 progressionin unvaccinated SARS-CoV-2 patients. Methods A prospective cross-sectional study was carried out in a cohort of 160 unimmunized, adult COVID-19 patients from the Hospital Universitario 12Octubre. Participants were classified into four clinical groups based on disease severity: non-survivors with respiratory failure (RF), RF survivors, patients requiring oxygen therapy and those not receiving oxygen therapy. Serum samples were taken on admission and IgM, IgG, IgG subclass antibody titers were determined by ELISA, and neutralizing antibody titersusing a surrogate neutralization assay. The differences in the antibody titers between groups and the association between the clinical and analytical characteristics of the patients and the antibody titers were analyzed. Results Patients that developed RF and survived had IgM titers that were 2-fold higher than non-survivors (p = 0.001), higher levels of total IgG than those who developed RF and succumbed to infection (p< 0.001), and than patients who required oxygen therapy (p< 0.05), and had 5-fold higher IgG1 titers than RF non-survivors (p< 0.001) and those who needed oxygen therapy (p< 0.001), and 2-fold higher than patients that did not require oxygen therapy during admission (p< 0.05). In contrast, RF non-survivorshad the lowest neutralizing antibodylevels, which were significantly lower compared those with RF that survived (p = 0.03). A positive correlation was found between IgM, total IgG, IgG1 and IgG3 titers and neutralizing antibody titers in the total cohort (p ≤ 0.0036). Conclusions We demonstrate that patients with RF that survived infection had significantly higher IgM, IgG, IgG1 and neutralizing titers compared to patients with RF that succumb to infection, suggesting that using humoral response variables could be used as a prognostic marker for guiding the clinical management of unimmunized patients admitted to the hospital for SARS-CoV-2 infection.
Tissue Flossing Around the Thigh Does Not Provide Acute Enhancement of Neuromuscular Function

Nowadays, various methods are used for acute performance enhancement. The most recent of these is tissue flossing, which is becoming increasingly popular for both performance enhancement and rehabilitation. However, the effects of flossing on athletic performance have not been clearly demonstrated, which could be due to differences in the methodology used. In particular, the rest periods between the end of the preconditioning activity and the performance of the criterion task or assessment tools varied considerably in the published literature. Therefore, the present study aimed to investigate the effects of applying tissue flossing to the thigh on bilateral countermovement jump performance and contractile properties of vastus lateralis (VL) muscle. Nineteen recreational athletes (11 males; aged 23.1 ± 2.7 years) were randomly assigned to days of flossing application (3 sets for 2 min of flossing with 2 min rest between sets) with preset experimental pressure (EXP = 95 ± 17.4 mmHg) or control condition (CON = 18.9 ± 3.5 mmHg). The first part of the measurements was performed before and after warm-up consisting of 5 min of cycling followed by dynamic stretching and specific jumping exercises, while the second part consisted of six measurement points after flossing application (0.5, 3, 6, 9, 12, 15 min). The warm-up improved muscle response time (VL = -5%), contraction time (VL = -3.6%) muscle stiffness (VL = 17.5%), contraction velocity (VL = 23.5%), jump height (13.9%) and average power (10.5%). On the contrary, sustain time, half-relaxation time and take-off velocity stayed unaltered. Flossing, however, showed negative effects for muscle response time (F = 18.547, p < 0.001), contraction time (F = 14.899, p < 0.001), muscle stiffness (F = 8.365, p < 0.001), contraction velocity (F = 11.180, p < 0.001), jump height (F = 14.888, p < 0.001) and average power (F = 13.488, p < 0.001), whereas sustain time, half-relaxation time and take-off velocity were unaffected until the end of the study protocol regardless of condition assigned and/or time points of the assessment. It was found that the warm-up routine potentiated neuromuscular function, whereas the flossing protocol used in the current study resulted in fatigue rather than potentiation. Therefore, future studies aimed to investigate the dose-response relationship of different configurations of preconditioning activities on neuromuscular function are warranted.
Feasibility of an Automatic Ultrasonographic Image Acquisition System Associated With an Artificial Intelligence Algorithm for Real-Time Monitoring of Cardiac Motion During Cardiac Radio-Ablation

Background The management of the cardio-respiratory motion of the target and the reduction of the uncertainties related to patient's positioning are two of the main challenges that stereotactic arrhythmia radio-ablation (STAR) has to overcome. A prototype of a system was developed that can automatically acquire and interpret echocardiographic images using an artificial intelligence (AI) algorithm to calculate cardiac displacement in real-time. Methods We conducted a single center study enrolling consecutive patients with a history of ventricular arrhythmias (VA) in order to evaluate the feasibility of this automatic acquisition system. Echocardiographic images were automatically acquired from the parasternal and apical views with a dedicated probe. The system was designed to hold the probe fixed to the chest in the supine position during both free-breathing and short expiratory breath-hold sequences, to simulate STAR treatment. The primary endpoint was the percentage of patients reaching a score ≥2 in a multi-parametric assessment evaluating the quality of automatically acquired images. Moreover, we investigated the potential impact of clinical and demographic characteristics on achieving the primary endpoint. Results We enrolled 24 patients (63 ± 14 years, 21% females). All of them had a history of VA and 21 (88%) had an ICD. Eight patients (33%) had coronary artery disease, 12 (50%) had non-ischemic cardiomyopathy, and 3 had idiopathic VA. Parasternal, as well as apical images were obtained from all patients except from one, in whom parasternal view could not be collected due to the patient's inability to maintain the supine position. The primary endpoint was achieved in 23 patients (96%) for the apical view, in 20 patients (87%) for the parasternal view, and in all patients in at least one of the two views. The images' quality was maximal (i.e., score = 4) in at least one of the two windows in 19 patients (79%). Atrial fibrillation arrhythmia was the only clinical characteristics associated with a poor score outcome in both imaging windows (apical p = 0.022, parasternal p = 0.014). Conclusions These results provide the proof-of-concept for the feasibility of an automatic ultrasonographic image acquisition system associated with an AI algorithm for real-time monitoring of cardiac motion in patients with a history of VA.
Sex-Dependent Synaptic Remodeling of the Somatosensory Cortex in Mice With Prenatal Methadone Exposure

Rising opioid use among pregnant women has led to a growing population of neonates exposed to opioids during the prenatal period, but how opioids affect the developing brain remains to be fully understood. Animal models of prenatal opioid exposure have discovered deficits in somatosensory behavioral development that persist into adolescence suggesting opioid exposure induces long lasting neuroadaptations on somatosensory circuitry such as the primary somatosensory cortex (S1). Using a mouse model of prenatal methadone exposure (PME) that displays delays in somatosensory milestone development, we performed an un-biased multi-omics analysis and investigated synaptic functioning in the primary somatosensory cortex (S1), where touch and pain sensory inputs are received in the brain, of early adolescent PME offspring. PME was associated with numerous changes in protein and phosphopeptide abundances that differed considerably between sexes in the S1. Although prominent sex effects were discovered in the multi-omics assessment, functional enrichment analyses revealed the protein and phosphopeptide differences were associated with synapse-related cellular components and synaptic signaling-related biological processes, regardless of sex. Immunohistochemical analysis identified diminished GABAergic synapses in both layer 2/3 and 4 of PME offspring. These immunohistochemical and proteomic alterations were associated with functional consequences as layer 2/3 pyramidal neurons revealed reduced amplitudes and a lengthened decay constant of inhibitory postsynaptic currents. Lastly, in addition to reduced cortical thickness of the S1, cell-type marker analysis revealed reduced microglia density in the upper layer of the S1 that was primarily driven by PME females. Taken together, our studies show the lasting changes on synaptic function and microglia in S1 cortex caused by PME in a sex-dependent manner.
Case Report: Effects of Multiple Seasons of Heavy Strength Training on Muscle Strength and Cycling Sprint Power in Elite Cyclists

Sprint performance is critical for endurance performance in sports characterized by multiple accelerations like a cross-country Olympic mountain bike (XCO MTB) race. There are indications that 10–25 weeks of heavy strength training (HST) can improve cycling sprint power in cyclists. However, there is a lack of data on the effect of continuing HST across several seasons. In the first part of this case report, two elite cyclists performed HST across two preparatory periods (i.e., 1.5 years), while two others continued with endurance training only. HST induced a mean increase in leg press force and cycling sprint power of 16% after the first preparatory period (November to April), which was maintained during the competition period. After the next preparatory period a further increase from the first test was achieved (22 and 19%, respectively). The two cyclists with no HST had no changes in leg press force and cycling sprint power. The second part contains data from two of the cyclists from the first part. One of them continued with HST for 2 more years and achieved a continuous increase in leg press force during all four preparatory periods, ending up with a total increase of 44% after 3.5 years, while the development of cycling sprint power had more variation with an apparent plateau from the third to fourth preparatory periods, ending up with an improvement of 25%. The other cyclist did not perform HST in the first part but started with HST and performed this across the last two preparatory periods. After two preparatory periods with HST (i.e., 1.5 years), the increased leg press force and cycling sprint power were 24 and 22%, respectively, which was in the same range as the improvement observed after 1.5 years of HST in the first part of this case report. The present data extend previous short-term studies indicating that HST can give reasonable muscle strength improvements in elite cyclists across multiple preparatory periods. Furthermore, the present data indicate that HST adaptations can be maintained across multiple competition periods. Cycling sprint power seems to approximately follow the development of leg press performance.
PICTORIAL STIMULI IN CONJOINT-ANALYSIS - TO SUPPORT PRODUCT STYLING DECISIONS

Commercial conjoint applications usually involve verbal descriptions of hypothetical products. The authors argue that pictorial stimuli should be used when consumers' market-place choices are strongly guided by the product's styling, such that the choices are heavily based on an inspection of actual products or pictures of products. Alternative methods for depicting product styling in a conjoint application are described. The authors propose computer-aided design and computer graphics as the most promising methods and discuss an application of conjoint analysis based on computer-generated pictorial representations of car stereos. The results showed that consumers had the least preference for the styling option which management would have chosen in the absence of the conjoint analysis application.
Data-driven Approach to Information Sharing using Data Fusion and Machine Learning for Intrusion Detection

Intrusion Detection System (IDS) sensors are employed in various locations in computer and communication networks to identify possible malicious activities. One of the main challenges with IDS is the high false positives rate, which creates a high unnecessary workload for human analysts at Security Operation Centre (SOC). Similarly, the exponential growth of captured sensor raw data combined with the application of Threat Intelligence (TI) creates a complex data flow. Considering mentioned challenges, this paper presents a model of heterogeneous sensor and TI data fusion and reduction in intrusion detection. We summarize found literature and qualitative research interviews with security experts from law enforcement and public and private organizations. Building on our qualitative research we identied feature subsets for corresponding data fusion that produce accurate classication model in Machine Learning (ML)-aided analysis. Proposed data fusion process model was successfully evaluated on a real-world dataset from a SOC. This work contributes to development of data-driven approach for automated classication of IDS events using reduction of raw log data.
Future Work Self Salience and Future Time Perspective as Serial Mediators Between Proactive Personality and Career Adaptability

In recent years, employment has become a growing problem for Chinese college students, who often face issues of slow employment and lazy employment. Guided by the framework of career construction theory, we explored how proactive personality strengthens career adaptability. A total of 423 Chinese college students effectively completed the online survey. The results showed a positive correlation between proactive personality, future work self salience, future time perspective, and career adaptability. Additionally, proactive personality can directly affect career adaptability through three indirect paths: the separate intermediary effect of future work self salience, future time perspective, and the continuous mediating role of future work self salience and future time perspective. The results indicate that proactive personality increases career adaptability through the mediating role of future work self salience and future time perspective. This study contributes to our understanding of the mechanisms underlying the relationship between proactive personality and career adaptability. Additionally, the findings have implications for the career development of college students.
Rule Changes to Increase Shared Medal Winning at the Olympics

One of the most inspirational moments of the Tokyo Olympics was the sharing of the gold medal in the men's high jump. Rule changes that allow more medal sharing when athletes and teams are effectively equal in ability would improve the entertainment value of the Olympics, reward more athletes for their years of dedication to sport, and augment the Olympic ideal of fair play. Medals in all events are decided by a time, distance or points score in a final. When scores differ by ~0.1 or less of the variability in the score between competitions, the athlete or team with the better score would obtain a better score on average in only 52% of subsequent competitions, representing medals determined effectively by a coin toss. We have therefore quantified the medal sharing at the Tokyo Olympics that would have occurred if medals had been shared with such score differences (converted to rounded times or distances separating athletes in a final) in events with known variability between competitions (canoeing, kayaking, rowing, swimming, track and field events). In these events, 10%, 14% and 14% respectively of gold, silver and bronze medals would have been shared. The men's high jump would have produced three golds. Most of the sharing (68%) would have occurred with male athletes, presumably because greater depth of competition with males results in smaller differences between athletes at the highest level. The variability of performance scores in other events between competitions would need researching to establish maximum score differences for medal sharing in these events. For all events, the rule changes should exclude counting back, penalty shoot-outs, tie-breakers and any other methods for avoiding ties in the final. The acceptability of these rule changes to athletes, coaches and spectators (for example, in terms of separation of the athletes at the finishing line) would also need to be investigated.
Galleria mellonella Larvae as a Model for Investigating Fungal—Host Interactions

Galleria mellonella larvae have become a widely accepted and utilised infection model due to the functional homology displayed between their immune response to infection and that observed in the mammalian innate immune response. Due to these similarities, comparable results to murine studies can be obtained using G. mellonella larvae in assessing the virulence of fungal pathogens and the in vivo toxicity or efficacy of anti-fungal agents. This coupled with their low cost, rapid generation of results, and lack of ethical/legal considerations make this model very attractive for analysis of host-pathogen interactions. The larvae of G. mellonella have successfully been utilised to analyse various fungal virulence factors including toxin and enzyme production in vivo providing in depth analysis of the processes involved in the establishment and progression of fungal pathogens (e.g., Candida spps, Aspergillus spp., Madurella mycetomatis, Mucormycetes, and Cryptococcus neoformans). A variety of experimental endpoints can be employed including analysis of fungal burdens, alterations in haemocyte density or sub-populations, melanisation, and characterisation of infection progression using proteomic, histological or imaging techniques. Proteomic analysis can provide insights into both sides of the host-pathogen interaction with each respective proteome being analysed independently following infection and extraction of haemolymph from the larvae. G. mellonella can also be employed for assessing the efficacy and toxicity of antifungal strategies at concentrations comparable to those used in mammals allowing for early stage investigation of novel compounds and combinations of established therapeutic agents. These numerous applications validate the model for examination of fungal infection and development of therapeutic approaches in vivo in compliance with the need to reduce animal models in biological research.
A Qualitative Study Exploring Management of Food Intake in the United Kingdom During the Coronavirus Pandemic

The coronavirus pandemic has impacted dietary quality through increased emotional eating and extended time spent at home, as well as instances of panic buying due to uncertainty over food availability. We recruited an opportunistic sample of 40 adults living in the United Kingdom (Female = 25; Mean age = 41.9 years) (SD = 14.4) without any prior history of eating disorders. Semi-structured interviews were conducted in June 2020 and focused on the impacts of the COVID-19 lockdown on eating habits and experiences of panic buying. The data were transcribed and organized using the softwares Otter and Quirkos, respectively. Reflexive thematic analysis identified positive and negative changes to eating habits. Overall, themes highlighted that effective organization was vital to manage food purchases and consumption due to a reduced shopping frequency. However, overconsumption frequently occurred due to boredom and ease of accessing energy dense foods, which had negative implications for weight and body image. After indulging, participants attempted to revert to prior eating habits and adhere to a nutritious diet. Many also expressed the importance of having enough food to feed families, which was often reported as a reason for buying extra supplies. Understanding the long-term impacts of changes to eating habits that account for the novel coronavirus context is required to preserve health and prevent unintended changes to weight.