Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Experience of TACE Combined with Atezolizumab plus Bevacizumab for Patients with Intermediate-Stage Hepatocellular Carcinoma beyond Up-to-Seven Criteria: A Multicenter, Single-Arm Study

Aim Locoregional treatment, such as TACE, in combination with immunotherapy may elicit a synergistic anticancer effect. However, TACE combined with atezolizumab plus bevacizumab (atezo/bev) has not been investigated for patients with intermediate stage (BCLC B) HCC beyond the up-to-seven criteria. This study aims to evaluate the efficacy and safety of this treatment strategy in intermediate-stage HCC patients with large or multinodular tumors exceeding the up-to-seven criteria. Methods This multicenter retrospective study included patients with intermediate stage (BCLC B) HCC beyond the up-to-seven criteria treated with TACE combined with atezo/bev from five centers in China from March to September 2021. The outcomes of this study included the objective response rate (ORR), overall survival (OS), and progression-free survival (PFS). Treatment-related adverse events (TRAEs) were analyzed to assess safety. Results A total of 21 patients were enrolled in this study, with a median follow-up duration of 11.7 months. According to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, the best ORR was 42.9% and the DCR was 100%. According to modified RECIST (mRECIST), the best ORR and DCR were 61.9% and 100%, respectively. The median PFS and OS were not reached. The most common TRAEs at all levels were fever (71.4%), and the most common grade 3/4 TRAE was hypertension (14.3%). Conclusions TACE combined with atezo/bev showed encouraging efficacy and an acceptable safety profile, making it a promising treatment option for patients with BCLC B HCC beyond the up-to-seven criteria, which will be further investigated in a prospective single-arm trial.
Pengaruh Inflasi, Tingkat Suku Bunga dan Nilai Tukar Terhadap Indeks Harga Saham Gabungan (IHSG) Bursa Efek Indonesia

The Influence of Inflation, Interest Rates, and Exchange Rates on the Composite Stock Price Index in the Indonesia Stock Exchange. The purpose of this study is. This study aims to determine the effect of inflation, interest rates and exchange rates on the Composite Stock Price Index in the Indonesia Stock Exchange. The population used in this study is 120 samples, using a purposive sampling technique with criteria set by the author. The analysis used is a multiple linear regression analysis methods. Based on the test results simultaneously, it is found that the variables of Inflation, Interest Rates, and Exchange Rates simultaneously have a positive effect on the Composite Stock Price Index on the Indonesia Stock Exchange. Also, partial inflation, interest rates and Exchange rates positively affect the Composite Stock Price Index on the Indonesia Stock Exchange.
Diagnostic Tests for SARS COV-2: Application, Challenges and Recommendations

Background: The recent pandemic of human coronavirus infections, at the beginning of the 21st century, have shown the prominent roles of rapid and accurate diagnostic technologies to contain the emerging and re-emerging infections. To control such a large-scale crisis, early identification and prevention of infection are essential. Prompt identification of cases relies on the accurate diagnostic technologies. Before analysis, appropriate sample collection is essential for making a precise molecular diagnosis of SARS-COV-2 (Severe Acute Respiratory Syndrome Coronavirus-2). To prevent further spread of infection and obtain consistent results, proper preventive measures must be taken into consideration to keep laboratory staff safe. Despite the development of specific and sensitive point-of-care tests and serological immunoassays which are considered supplementary methods for diagnosing SARS-COV-2, RT-PCR (Reverse-Transcriptase Polymerase-Chain-Reaction) remains the gold standard performed on respiratory specimens. Upon completion of the sample analysis, testing results must be interpreted using both molecular and serological findings. Finally, random-access, integrated devices available for the purpose of care with scalable capacities will facilitate the rapid and accurate diagnosis and monitoring of Severe Acute Respiratory Syndrome Corona Virus-2 (SARS CoV-2) infections. Objectives: This review covers the types of sample collection, current diagnostic techniques for COVID-19 and challenges in their application Methods: A literature search was performed on the lines for a narrative review, but including features of systematic review methodology (PRISMA flow diagram). Two authors searched three electronic databases for literature review, i.e., PubMed, HINARI, and Google Scholar using Mesh-terms, specimen types or molecular diagnostic tests or serological tests in link with COVID-19 or SARS CoV-2, with different combinations, between March 21, 2020 and March 8, 2023. Conclusion: To control the current pandemic of COVID-19 and reduce its burden on healthcare systems around the world, the capacity of diagnostic tests should be improved. Rapid molecular diagnostic tests that can be fast, reliable, cost-effective, available, sensitive, and specific and point of care, must be urgently developed, produced, and widely distributed all over the globe.
Un théorème ergodique polynômial ponctuel pour les endomorphismes exacts et les K-systèmes

On etablit, pour les endomorphismes exacts et les K-systemes, la convergence presque sure de certaines moyennes ergodiques du type « recurrence multiple » introduites par H. Furstenberg. Pour des systemes dynamiques inversibles, on reduit en fait le probleme de la convergence presque sure de ces moyennes au cas des systemes dynamiques d'entropie nulle.
Evaluating the impacts of watershed rehabilitation and irrigation interventions on vegetation greenness and soil erosion using remote sensing and biophysical modelling in Feresmay watershed in Ethiopia

ABSTRACT Soil erosion and subsequent land degradation undermine efforts to ensure food security and environmental sustainability in Ethiopia. The government of Ethiopia has implemented extensive soil and water conservation (SWC) programs in severely degraded and food-insecure areas of the country, in some cases integrated with subsequent or parallel irrigation development. However, the effectiveness of these interventions has not been extensively evaluated. This study, therefore, evaluates the performance and impacts of SWC practices in terms of improving vegetation greenness and reducing soil erosion in Feresmay watershed in Ethiopia. Long-term Landsat-based Normalised Difference Vegetation Index (NDVI), Revised Universal Soil Loss Equation (RUSLE), and Soil and Water Assessment Tool (SWAT) were used for change-detection analysis before and after the implementation of various SWC interventions. The results revealed the positive impacts of SWC interventions in improving the vegetation greenness and soil erosion reduction although the outcome varied by intervention. Increased vegetation greenness was observed largely in areas where area closure with catchment treatment (ACCT) and impacts of irrigation (IRR) interventions are dominant, while relatively little impact was observed at the watershed level analysis. Although these interventions helped to reduce soil loss, the results highlighted the need for more SWC interventions to minimise further soil loss.
The eggshell method for the computation of electromagnetic forces on rigid bodies in 2D and 3D

This paper presents a technique to compute electromagnetic forces on rigid bodies. It is applicable in 2D and in 3D, and with dual formulations. The method requires only volume integrations although it originates from the Maxwell stress tensor. It clarifies the relationship between the latter and the virtual work principle. MAXWELL STRESS TENSOR A system Ω with a moving rigid piece is considered. An eggshell shaped region S, of thickness δ <<, is placed so to enclose the moving piece. The shell can be in contact or not with the moving piece but it must entirely lie in air. The interior and exterior of the egg are called Y and Z, so that Y ∪ S ∪ Z = Ω. The value of the magnetic force acting on Y is Fi = ∫ Γ σijn dΓ where σij is the Maxwell stress tensor [1] and Γ a closed surface that encloses the moving piece. PSfrag replacements S Y Z Fig. 1. Geometry of the c-core and detail of the mesh in the airgap. THE EGGSHELL METHOD The eggshell method is a generalisation of the Arkkio formula for torque in electrical machines [2]. The idea is to consider the eggshell S as a family of concentric equivalent surfaces for the evaluation of the magnetic force by the Maxwell stress tensor method, and to average them
Development of a bubble-jet-type air-lift-pump (feasibility test and performance prediction)

An advanced micro-bubble generator with a spherical body in a flowing water tube was invented by Sadatomi in 2003. In the present paper, as an industrial application of the micro-bubble generator, a bubble-jet-type air-lift-pump also invented by Sadatomi in 2005 has been presented together with the results of its feasibility test. In the test, effects of particles size, submergence ratio (=the riser length submerged in water divided by the total riser length), and water and air supply rates to the bubble-jet generator on the pump rerformance have been studied. Yoshinaga-Sato model for predicting water and particles discharge rates has been modified and tested against the present experimental data to confirm its validity. The results of such experiments and analyses are reported in this paper.
The Impact of Coronavirus Disease 2019 Pandemic on Female Patients Seeking or Undergoing Fertility Treatment in a Single In vitro Fertilisation Clinic in Greece: An International, Cross-sectional Study

Background: The temporary delay in fertility treatments due to the coronavirus disease 2019 (COVID-19) pandemic, in combination with the imposed lockdowns, has created psychological distress and anxiety amongst infertile patients. Aims: The aim of this study was to evaluate how the pandemic has influenced assisted reproduction technology (ART) patients in Greece, during the second wave of the pandemic. An additional aim was to examine the effects of the pandemic on cross-border patients in particular, compared to national ones. Settings and Design: This study was a cross-sectional, questionnaire-based study, distributed to 409 patients of a single in vitro fertilisation (IVF) clinic in Greece, during the period between January until the end of April 2021. Materials and Methods: The survey was conducted online via E-mail and was distributed to national and international female patients of a single IVF clinic in Greece, who were undergoing ART treatment during the second wave of the COVID-19 pandemic. Patient participation was anonymous, and participants provided informed consent for collection and publication of data. Statistical Analysis Used: The mean values of baseline characteristics, along with answer percentages per questionnaire item, were calculated. Collected data were cross-tabulated, and the Chi-square test was used as a measurement of the differences between national and cross-border patients. A P value lower than 0.05 was considered statistically significant. All analyses were conducted using the SPSS Statistics software. Results: From 409 initial candidates, 106 women, with a mean age of 41.2 years, completed the questionnaire (26% response rate). The majority of national patients did not experience any delays in their fertility plans (62%), while cross-border patients experienced over 6 months of delays (54.7%). The main reason for fertility postponement was travel restrictions due to COVID-19 for cross-border patients (62.5%), while national patients cited additional reasons. The majority of patients experienced a degree of stress (65.2%) due to the delays, however were not fearful of COVID-19 infection (54.7%). Most patients were aware of the protective measures taken by IVF clinics (80.2%), and this was a determinant factor (71.7%) for their decision to restart their fertility treatment. Conclusion: The COVID-19 pandemic lockdowns had a significant emotional impact on patient receiving or undergoing ART treatment in Greece. This impact was more pronounced on cross-border patients. This highlights the need for continuation of ART care, with the appropriate protective measures, during the pandemic, as well as during similar times of crisis in the future.
Muslim Non-Cash Transaction Behavior: The Moderating Role of Religiosity

Despite years of exploration, empirical evidence regarding the mediating role of religiosity in the relationship between non-cash interest and behavior is still lacking. This study analyzed the behavior related to the use of non-cash transactions by Muslim communities moderated by religiosity based on the TAM model. The sampling technique in this study used purposive sampling with a total of 438 respondents. The data in this study were analyzed using Partial Least Square Structural Equation Model (PLS-SEM) with Smart PLS 3.0. The results of this study reveal that religiosity can moderate the interest and behavior of using non-cash transactions. Besides that, the perceived ease of use and perceived usefulness have a significant positive effect on consumer behavior in using non-cash transactions, which are proxied by attitude and interest. These results indicate that the Muslim community is accepting and even supporting the development of technology in the payment system because technology brings convenience and benefits. As a result, players in the Islamic finance and halal market should pay close attention to the advancements in payment system technology to ensure the Muslim community prefers payment products on the Sharia market.
Usability and Preliminary Efficacy of an Artificial Intelligence–Driven Platform Supporting Dietary Management in Diabetes: Mixed Methods Study

Background Nutrition plays an important role in diabetes self-management. Web-based diabetes care, driven by artificial intelligence (AI), enables more personalized care. Objective This study aimed to examine the usability and preliminary efficacy of a web-based AI-driven nutrition platform to support people with diabetes and their carers in identifying healthy recipes, meal planning, and web-based shopping. Methods Diabetes UK signposted people with diabetes and their carers to the platform’s study-specific portal through its website, social media, and newsletters. A total of 73 adult participants with prediabetes or diabetes or their carers completed the baseline web-based survey. Of these 73 participants, 23 (32%) completed a web-based survey after 8 weeks of platform use. Web-based semistructured interviews were conducted with platform users (7/23, 30%) who agreed to be followed up and diabetes experts (n=3) who had nutrition and platform knowledge. The intervention consists of a web-based platform that incorporates AI to personalize recipes, meal planning, and shopping list experiences and was made available for 8 weeks. Baseline characteristics, satisfaction, system usability, and diabetes-related and general health indicators were assessed before and after using the platform for 8 weeks. Results Reductions in weight (mean difference 4.5 kg/m2, 95% CI 1.0-12.0; P=.009; Cliff δ=0.33) and waist size (mean difference 3.9 cm, 95% CI 2.0-6.5; P=.008; Cliff δ=0.48) were found. Most of the participants (151/217, 69.6%) did not regularly use the platform and had low or very low engagement scores. However, the platform was perceived as accessible with no need for additional assistance (11/21, 52%), user-friendly (8/21, 38%), and easy to use (8/21, 38%), regardless of some usability issues. Saving recipes was the most popular feature, with 663 saved recipes. Conclusions This study indicated that the usability of the nutrition platform was well perceived by users and their carers. As participants managed their diabetes well, adding an education component would be specifically relevant for people less familiar with the role of diet in diabetes management. To assess the platform’s effectiveness in improving diabetes-related health indicators, controlled studies with a larger and more diverse participant sample are recommended.
Spatial structure of the Bénard von Kármán instability

A complete description of both the temporal and spatial characteristics is essential for the understanding of the mechanisms generating and sustaining the instability in the infinite cylinder wake. Experimental methods have been able to provide accurate measures of the temporal characteristics but present serious limitations for the study of the spatial structure of the instability. Numerical simulations give access to a full space-time picture of the instability, however the amount of numerical data makes it impossible to use them in their raw form even in 2D. After relaxation of transients the instability reaches a limit cycle described in a natural way by a set of Fourier harmonics. We present the results obtained by an on-line processing of a direct simulation of an infinite cylinder wake at saturation for Re = 48 and Re = 100. The spatial structure of individual harmonics up to 5 is analyzed. The characteristics of the envelopes of the harmonics and of the phases (wave length, phase velocity) are visualized and studied over the whole flow field.
Do We Learn From Errors? The Economic Impact of Differentiated Policy Restrictions in Italy

This paper investigates the economic impact of the three tiers risk framework implemented in Italy against the COVID-19 pandemic during the Autumn of 2020. Exploiting a large-scale dataset encompassing daily credit card transactions mediated by a large Italian bank, we estimate a set of panel event study models to disentangle the impact of restrictions with low, medium and high stringency levels in terms of consumption reduction. We show that space-time differentiated policies tend to produce stronger welfare losses for progressively more stringent restrictions in specific sectors targeted by these policies such as Retail and Restaurants. However, when we compare provinces implementing the same level of policy stringency, we show that territories with higher income per capita and larger concentration of manufacturing and service activities experience both significantly worse economic and epidemiological performances. Overall, our results suggest that policy makers should properly account for local socio-economic characteristics when designing tailored restrictions entailing an equal and homogeneous impact across territories.
Analysis of Results from Second International Ice Nucleus Workshop with Emphasis on Expansion Chambers, NCAR Counters, and Membrane Filters.

Abstract The Second International Workshop on Condensation and Ice Nuclei, held at Ft. Collins, Colo. , in 1970, provided approximately 10,000 measurements by ice nucleus counters of natural and artificial aerosols, with the counters operating under well-defined conditions. Relevant data on nucleus aerosol size and concentration, and the properties of related condensation nuclei were provided. A first review of the data showed a number of serious discrepancies between the various instruments. This paper gives a detailed analysis of data from ten instruments and makes clear the origin of the discrepancies, which are related to the degree of supersaturation and its relationship to the concentration of condensation nuclei during cloud formation. Different instruments respond differently to these variables but the present results make it evident that meaningful results can be obtained with the counters now available.
Phase-locked trajectories for dynamical systems on graphs

We prove a general result on the existence of periodic trajectories of systems of difference equations with finite state space which are phase-locked on certain components which correspond to cycles in the coupling structure. A main tool is the new notion of order-induced graph which is similar in spirit to a Lyapunov function. To develop a coherent theory we introduce the notion of dynamical systems on finite graphs and show that various existing neural networks, threshold networks, reaction-diffusion automata and Boolean monomial dynamical systems can be unified in one parametrized class of dynamical systems on graphs which we call threshold networks with refraction. For an explicit threshold network with refraction and for explicit cyclic automata networks we apply our main result to show the existence of phase-locked solutions on cycles.
The most unmet needs on Gynecological and Breast Cancer Survivors, A Systematic Review

Introduction: The complexity of treating gynecological and breast cancer causes unmet needs for survivors. This systematic review aimed to identify the most unmet needs of gynecological and breast cancer survivors from the available evidence. Method: Researchers searched the electronic databases PubMed, Cochrane, CINAHL, Ebsco Host, and Science Direct with predetermined criteria. The keywords used were combinations of "gynaecologic* cancer" OR "gynaecologic* cancer survivors" OR "breast cancer" OR "breast cancer survivors" AND "unmet needs. " A systematic review was made using PRISMA, the critical appraisal was carried out with the JBI instrument, and bias analysis was carried out using the Robvis Tool. Results: There are 12 selected articles. The two highest unmet needs domains for gynecological and breast cancer survivors are the health system information and psychological domains. Conclusions: Nurses and other health workers must pay attention to implementing holistic care to meet the various needs of gynecological cancer survivors, including health system information and psychological domains. Introduccion: La complejidad del tratamiento del cancer ginecológico y de mama genera necesidades insatisfechas para los sobrevivientes. Esta revisión sistemática tuvo como objetivo identificar las necesidades más insatisfechas de las sobrevivientes de cancer ginecológico y de mama a partir de la evidencia disponible. Método: Los investigadores realizaron búsquedas en las bases de datos PubMed, Cochrane, CINAHL, Ebsco Host, Science Direct con criterios electrónicos predeterminados. Las palabras claves usadas fueron combinacion de " cáncer " ginecológico *"O" sobrevivientes de cáncer ginecológico *" O " cáncer de mama" O " sobrevivientes de cáncer de mama" Y " necesidades insatisfechas ". Se realizó una revisión sistemática mediante PRISMA, la evaluación crítica se realizó con el instrumento JBI y el análisis de sesiones mediante la herramienta Robvis.Resultados: Hay 12 artículos seleccionados. Los dos dominios de necesidades insatisfechas más importantes para los sobrevivientes de cáncer ginecológico y cáncer de mama son el dominio de informacion del sistema de salud y el dominio psicológico. Conclusión: Las enfermeras y otros trabajadores de la salud deben prestar atencion a la implementacion de una atención holística para satisfacer las diversas necesidades de los sobrevivientes de cancer ginecológico, incluidas las necesidades de información del sistema de salud y los dominios psicológicos.