Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of canagliﬂozin on the risk of neuropathy events: a post-hoc exploratory analysis of the CREDENCE trial

Aim. - Canagliflozin reduces the risk, and progression, of diabetic kidney disease. We hypothesized that it may improve the microvascular complication of neuropathy. Methods . - The CREDENCE trial randomized participants with type 2 diabetes and kidney disease to canagliflozin 100mg daily or placebo. Neuropathy events were defined post-hoc as any reported adverse event consistent with a peripheral or autonomic neuropathy event. The effect of canagliflozin and predictors of neuropathy events were estimated using Cox regression analysis. In sensitivity analyses the endpoint was restricted to sensorimotor polyneuropathy, diabetic neuropathy, and non-autonomic neuropathy events. Results . - Almost half (48.8%) of the 4401 participants had a diagnosis of neuropathy at baseline. Over a median of 2.45 years of follow up, 657 people experienced a neuropathy event (63.2 per 1000 patient-years). Independent factors associated with higher risk of experiencing neuropathy events were non-white race, younger age, higher glycated haemoglobin and lower estimated glomerular filtration rate. The incidence of neuropathy events was similar in people randomized to canagliflozin and placebo (334/2202 vs. 323/2199; HR 1.04, 95% CI 0.89 to 1.21, P = 0.66). Canagliflozin had no impact on sensorimotor polyneuropathy (HR 0.93, 95% CI 0.69 to 1.25, P = 0.63), diabetic neuropathy (HR 0.91, 95% CI 0.68 to 1.22, P = 0.52), or non-autonomic neuropathy (HR 1.03, 95% CI 0.87 to 1.21, P = 0.77). The lack of effect on neuropathy events was consistent in subgroup analyses.
Host-mediated effects on fruit size variation of the hemiparasitic mistletoe Psittacanthus schiedeanus (Loranthaceae) Efectos mediados por hospedero en la variación del tamaño de frutos del muérdago hemiparásito Psittacanthus schiedeanus (Loranthaceae)

: Background and Aims: Most fruits of Psittacanthus mistletoes (Loranthaceae) depend on frugivorous birds for seed dispersal, and their spatial distribution patterns within and between hosts are strongly influenced by the behavior of seed dispersers. Despite the importance of birds in their dispersal and distribution, the effects of host species on fruit size variation have not been investigated to any large extent. The aim of this study was to characterize fruit size variation of Psittacanthus schiedeanus ripe fruits growing on different host species. We expect that the fruit size traits will vary according to the quality of host species, and that this variation will correspond to those in mistletoe reproductive success. Methods: Fully ripe fruits from Psittacanthus schiedeanus mistletoe plants growing on different host tree species were collected at two locations (Tlalnelhuayocan and Coapexpan) of cloud forest in central Veracruz, Mexico, measured (length and width and length of cupular pedicels) and weighed to describe fruit size differences. Key results: Cupular pedicel length and fruit size were significantly affected by host species. On average, longest cupular pedicels and larger fruits were found on plants growing on naturally growing Acacia pennatula , Quercus germana , Ostrya virginiana and Liquidambar styraciflua , whereas the smaller ones were found generally on cultivated host trees. Conclusions: The results provide us with valuable information for further species comparisons regarding the effects of host species on fruit size vari - ation. Although the effects of host species on fruit size variation might vary across space, fruit size differences might be the result of host-resource differences. Further study on fruit selection and fruit handling by seed dispersers is needed to discuss whether the observed fruit size variation correlates with fruit selection and handling by main consumers, and with successful attachment and establishment to host branch after gut passage.
In vivo RNA interactome pro�ling reveals 3’UTR-processed small RNA targeting a central regulatory hub

Small noncoding RNAs (sRNAs) are crucial regulators of gene expression in bacteria. Acting in concert with major RNA chaperones such as Hfq or ProQ, sRNAs directly base-pair with multiple target mRNAs, together forming a large and complex RNA-RNA interaction network. To systematically investigate the RNA-RNA interactome in living cells, we have developed a streamlined in vivo approach LiRIP-seq (LiRIP-seq, ligation RIP-seq). This generic approach is highly robust, illustrating the dynamic sRNA interactomes in Salmonella enterica across multiple stages of growth. Strikingly, we have identi�ed the OmpD porin mRNA as a central regulatory hub that is targeted by more than a dozen sRNAs. These include a novel sRNA FadZ that is processed from the conserved 3’ UTR of fadBA mRNA by RNase E. Our results show that both ompDand its regulator FadZ are activated by the same transcription factor upstream, constituting a type I incoherent feed-forward loop in the fatty acid metabolism pathway. Altogether, we have established a novel approach to pro�le RNA-RNA interactomes in live cells, providing insights into the complexity of post-transcriptional regulatory hubs in RNA interaction networks.
Association between Chlamydia pneumoniae antibodies and wheezing in young children and the influence of sex

Background: The proposed association between Chlamydia pneumoniae (Cpn) infection and wheezing needs further clarification. Methods: Serum samples obtained from 1581 children aged 4 years in a population based cohort were tested for antibodies to Cpn and IgE antibodies to common allergens. Data on environmental factors and disease were collected prospectively from birth. Results: The occurrence of IgG antibodies to Cpn at 4 years of age was associated with reported wheezing at different ages; however, these findings were most often not significant. In girls, the occurrence of anti-Cpn IgG was associated with wheezing at the ages of 1, 2, and 4 years (odds ratios (ORs) 3.41 (95% confidence interval (CI) 1.46 to 7.96), 2.13 (95% CI 1.02 to 4.44), and 2.01 (95% CI 1.14 to 3.54), respectively), and even higher ORs were observed for each age category when only high level antibody responses to Cpn were analysed. At the time of blood sampling the association between anti-Cpn IgG and wheezing was restricted to girls without atopic sensitisation (OR 2.39 (95% CI 1.25 to 4.57). No associations with wheezing were detected in boys, in whom IgE sensitisation was inversely associated with the presence of anti-Cpn IgG (OR 0.49 (95% CI 0.26 to 0.90). Conclusions: This study suggests an association between evidence of earlier Cpn infection and a history of wheezing in young girls. Infection with Cpn may be an important risk factor for wheezing and possibly for non-atopic asthma, predominantly in girls.
On the causes and dynamics of the early twentieth century North American pluvial

AbstractThe early twentieth-century North American pluvial (1905–17) was one of the most extreme wet periods of the last 500 yr and directly led to overly generous water allotments in the water-limited American west. Here, the causes and dynamics of the pluvial event are examined using a combination of observation-based datasets and general circulation model (GCM) experiments. The character of the moisture surpluses during the pluvial differed by region, alternately driven by increased precipitation (the Southwest), low evaporation from cool temperatures (the central plains), or a combination of the two (the Pacific Northwest). Cool temperature anomalies covered much of the West and persisted through most months, part of a globally extensive period of cooler land and sea surface temperatures (SST). Circulation during boreal winter favored increased moisture import and precipitation in the Southwest, while other regions and seasons were characterized by near-normal or reduced precipitation. Anomalies in th.
Mineralogy, nucleation and growth of dolomite in the laboratory and sedimentary environment: A review

Dolomite [CaMg(CO3)2] forms in numerous geological settings, usually as a diagenetic replacement of limestone, and is an important component of petroleum reservoir rocks, rocks hosting base metal deposits and fresh water aquifers. Dolomite is a rhombohedral carbonate with a structure consisting of an ordered arrangement of alternating layers of Ca2+ and Mg2+ cations interspersed with CO32− anion layers normal to the c‐axis. Dolomite has R3¯ symmetry, lower than the (CaCO3) R3¯c symmetry of calcite primarily due to Ca–Mg ordering. High‐magnesium calcite also has R3¯c symmetry and differs from dolomite in that Ca2+ and Mg2+ ions are not ordered. High‐magnesium calcite with near‐dolomite stoichiometry (≈50 mol% MgCO3) has been observed both in nature and in laboratory products and is referred to in the literature as protodolomite or very high‐magnesium calcite. Many dolomites display some degree of cation disorder (Ca2+ on Mg2+ sites and vice versa), which is detectable using transmission electron microscopy and X‐ray diffractometry. Laboratory syntheses at high temperature and pressure, as well as studies of natural dolomites show that factors affecting dolomite ordering, stoichiometry, nucleation and growth include temperature, alkalinity, pH, concentration of Mg and Ca, Mg to Ca ratio, fluid to rock ratio, mineralogy of the carbonate being replaced, and surface area available for nucleation. In spite of numerous attempts, dolomite has not been synthesized in the laboratory under near‐surface conditions. Examination of published X‐ray diffraction data demonstrates that assertions of dolomite synthesis in the laboratory under near‐ambient conditions by microbial mediation are unsubstantiated. These laboratory products show no evidence of cation ordering and appear to be very high‐magnesium calcite. Elevated‐temperature and elevated‐pressure experiments demonstrate that dolomite nucleation and growth always are preceded by very high‐magnesium calcite formation. It remains to be demonstrated whether microbial‐mediated growth of very high‐magnesium calcite in nature provides a precursor to dolomite nucleation and growth analogous to reaction paths in high‐temperature experiments.
The effect of Late Caledonian and Variscan continental escape tectonics on basement structure, Paleozoic basin kinematics and subsequent Mesozoic basin development in NW Europe

Caledonian structures in NW Europe formed by northwestward accretion of continental fragments and magma tic arcs onto the Proterozoic North Atlantic Craton. The main crustal fabrics were formed by Caledonian basin development, subsequent inversion, collision tectonics with thick-skinned and thin-skinned thrusts and large NW–SE strike-slip faults. These fabrics were modified and offset by late Caledonian displacement on NE–SW-trending strike-slip faults. Late Caledonian (Devonian and Early Carboniferous) tectonics in NW Europe resulted from the lateral expulsion of the English–North Sea–Baltic Block away from an Acadian indentor. The block was approximately triangular in shape bounded by (i) the Ural Ocean to the east, (ii) the left-lateral Great Glen–Midland Valley–North Atlantic shear systems to the NW and (iii) the right-lateral English Channel–South Polish Trough shear systems (in Devonian times) and the South Wales–Southern North Sea–Polish Trough shear zone (in Early Carboniferous times) to the south. During the Early Carboniferous the block expanded NW–SE, as it was released from the indentor, into space created by back-arc extension related to Variscan subduction. Pull-apart basins which developed along the shear systems include the following, (i) In the Northern North Sea, the West Orkney Basin–East Shetland Platform–Viking Graben formed as a large pull–apart basin in the left-lateral shear systems during Devonian/Early Carboniferous times, (ii) In the Southern North Sea and East Midlands, NW-trending Carboniferous basins developed in a right-lateral shear system, associated with clockwise rotation of Caledonian basement blocks. The Devonian and Carboniferous basin-fill depended on the position of the block boundary shear systems in the Caledonian and Variscan orogens and their thickened crust. The northern shear boundary affected crust c. 50 km thick following Caledonian collision and hence the syn-rift and post-rift sediment fill was dominantly intracontinental. In the south the basin developed in crust of average thickness and hence marine conditions were dominant during the extension. However, Devonian and Carboniferous basins in the Northern North Sea provided channels for sediment fill from the Caledonian mountains into the southern basins. During the Late Carboniferous, closure of the Ural Ocean and Ural plate collision reversed the sense of shear along the block margins and the wedge-shaped block was pushed back between the Acadian collision zones. This shear reversal caused inversion of the pull-apart and expansion basins in northern Britain. Subsequent reactivation of these basins during the Mesozoic was responsible for the tectonic framework of the North Sea.
CAE v2: Context Autoencoder with CLIP Latent Alignment

Masked image modeling (MIM) learns visual representations by predicting the masked patches on a pre-defined target. Inspired by MVP (Wei et al., 2022b) that displays impressive gains with CLIP, in this work, we also employ the semantically rich CLIP latent as target and further tap its potential by introducing a new MIM pipeline, CAE v2, to learn a high-quality encoder and facilitate model convergence on the pre-training task. CAE v2 is an improved variant of CAE (Chen et al., 2023), applying the CLIP latent on two pretraining tasks, i.e. , visible latent alignment and masked latent alignment. Visible latent alignment directly mimics the visible latent representations from the encoder to the corresponding CLIP latent, which is beneficial for facilitating model convergence and improving the representative ability of the encoder. Masked latent alignment predicts the representations of masked patches within the feature space of CLIP latent as standard MIM task does, effectively aligning the representations computed from the encoder and the regressor into the same domain. We pretrain CAE v2 on ImageNet-1K images and evaluate on various down-stream vision tasks, including image classification, semantic segmentation, object detection and instance segmentation. Experiments show that our CAE v2 achieves competitive performance and even outperforms the CLIP vision encoder, demonstrating the effectiveness of our method. Code is available at https://github.com/Atten4Vis/CAE .
Histomorphological Patterns and Helicobacter Pylori status of Gastric tissue biopsy by Giemsa histochemical stain at Bugando Medical Centre, Mwanza Tanzania

Background information: Helicobacter pylori (H. pylori) is one of the major public health problems worldwide, affecting more than 50% of the world’s population. In Tanzania, more than 50% of the population is infected by the H.pylori. Identi�cation of its infection is essential for its eradication. There is no speci�c method for detection of H. Pylori in gastric tissue biopsy at Bugando Medical Centre (BMC) rather than the routine Hematoxylin and Eosin (H&E) stain which has lower detection rate of 11.2%. Objective: To determine the histomorphological patterns and H. pylori status of gastric tissue biopsy by Giemsa stain at BMC. Methodology: This was retrospective cross-sectional study involves 300 gastric tissue blocks from January 2020 to January 2022 archived in histopathology laboratory at BMC. Gastric tissue blocks were sectioned, stained by H&E and Giemsa for histomorphological diagnosis and H. pylori status. Results:A 300 gastric biopsies were identi�ed, of which 53.75% were males and 46.3% were females. Majority of participants were 40 years and above 202(67.3%), most diagnosed with chronic gastritis 131 (43.7%), followed by gastric adenocarcinoma 115(38.3%), those aged bellow 20 years were only 24(8%). Males were predominantly diagnosed with Gastric adenocarcinoma (35.4%) and Gastric ulcers (4.9%) while majority of females had chronic gastritis (43.2%). by Giemsa stain, H . pylori was detected in only 106(35.3%). The association between H. pylori status with chronic gastritis, gastric adenocarcinoma, gastric polyps, gastric ulcers and gastric perforation were statistically signi�cance (p-value<0.05). Conclusion: By the use of Giemsa stain, H. pyloriwas detected in about one third of gastric tissue biopsy. Most
Transplantation of thermosensitive hydrogel encapsulated miR-216a-5p overexpressing mesenchymal stem cells for functional recovery of spinal cord injury

Spinal cord injury (SCI) is one of the most incapacitating conditions, with neuropathic pain (NP) as a comorbidity that is the most di�cult to treatment. In recent years, microRNAs (miRNAs) have been studied more thoroughly in SCI. In this study, based on the construction of the SCI rat model, miR-216a-5p expression was reduced in SCI rats through experimental validation analysis. And human mesenchymal stem cells (hMSCs) overexpressing miR-216a-5p were loaded by constructing thermosensitive hydrogels and transplanted into SCI rats. It was found that the constructed hydrogel system exhibited temperature-dependent phase change behavior and biodegradability, and rats with spinal cord injury showed considerable behavioral recovery and signi�cantly reduced cellular mortality after transplantation. Mechanistic studies revealed that sustained release of miR-216a-5p was able to bind to the 3'UTR of NUDT21 and involve in the regulation of recovery after SCI through modulation of NUDT21, thus greatly increasing recovery after spinal cord injury. Thus, thermosensitive hydrogel-encapsulated human mesenchymal stem cells overexpressing miR-216a-5p provide a microenvironmentally responsive and noninvasive pathway for recovery from spinal cord injury, we hypothesized that miR-216a-5p could be a potential biomarker for neuropathic pain.
Intra-or Extracranial Arterial Stenosis SPECT with Angiographic Flow Patterns and Measured by Acetazolamide-challenged Correlation of Cerebrovascular Reserve as

BACKGROUND AND PURPOSE: The ability to identify patients at increased risk for stroke from cerebral hemodynamic ischemia may help guide treatment planning. We tested the correlation between regional cerebrovascular reserve (rCVR) on acetazolamide-challenged single-photon emission CT (SPECT) brain scans and intracranial collateral pathways as well as extra-or intracranial (EC-IC) arterial stenosis on cerebral angiography. METHODS: A retrospective analysis of 27 patients who underwent cerebral angiography and acetazolamide-challenged SPECT brain imaging was performed. With cerebral angiography, the anterior, middle, and posterior cerebral artery (ACA, MCA, PCA) territories were evaluated for patterns of ﬂow, including the ipsilateral carotid or basilar arteries, the circle of Willis collaterals, the EC-IC collaterals, and the leptomeningeal collaterals. With acetazol-amide-challenged SPECT, the ACA, MCA, and PCA territories were classiﬁed as either showing or not showing evidence of decreased rCVR. Statistical signiﬁcance was determined by the (cid:120) 2 test. RESULTS: Patients with decreased rCVR had signiﬁcantly greater dependence on either the EC-IC or leptomeningeal collaterals (42%) than did patients without decreased rCVR (7%). Similarly, the cerebral hemispheres with decreased rCVR showed a higher prevalence of 70% or greater stenosis or occlusion of the ipsilateral EC-IC arteries in the anterior circulation (74%) than did hemispheres with no evidence of decreased rCVR (16%), and this difference was also statistically signiﬁcant. CONCLUSION: Acetazolamide-challenged SPECT brain scanning provides additional
A STUDY OF DIFFERENT PARAMETERS IN COMPLICATED VERSUS UNCOMPLICATED CHRONIC SUPPURATIVE OTITIS MEDIA

Chronic suppurative otitis media (CSOM) is characterized by persistent inflammation and purulent discharge within the middle ear. This observational study aimed to discern the distinctions between complicated and uncomplicated CSOM cases by examining clinical, microbiological, and radiological parameters. A total of 100 participants were enrolled, including 50 Complicated Cases with complicated CSOM and 50 Uncomplicated Cases with uncomplicated CSOM. Study conducted in the department of Otorhinolaryngology at the period of February 2022 to January 2023. The duration of otorrhea was significantly longer in complicated CSOM cases compared to uncomplicated cases (p < 0.05). The degree of hearing loss was significantly higher in complicated CSOM cases (p < 0.05). Otalgia was more prevalent in complicated CSOM cases (p < 0.05). Facial nerve involvement was significantly more frequent in complicated CSOM cases (p < 0.05). Pseudomonas aeruginosa was more commonly isolated from complicated CSOM cases (p < 0.05). Staphylococcus aureus and Streptococcus pneumoniae showed non-significant differences between groups (p > 0.05). Our observational study highlights the distinct clinical, microbiological, and radiological features of complicated and uncomplicated CSOM cases. The findings emphasize the importance of early recognition and appropriate management strategies for complicated cases.
A profile of the four moment measures perpendicular to a shoreline, South Haven, Michigan

ABSTRACT A series of fourteen samples was taken along a profile crossing a beach, berm, foreshore slope, plunge point, nearshore, offshore bar, and offshore area to study the changes in the first four moments. The mean grain size and standard deviation reached a maximum in the plunge zone and were also high on the offshore bar. Skewness and kurtosis values were highest in the nearshore and offshore area. The beach represents a phi normal distribution of fine sand which is mixed with varying amounts of coarser material to form the sediments in the other environments.
UNDERSTANDING FACTORS DETERMINING THE USE OF MOBILE APPS BY CUSTOMER: CUSTOMER MOBILITY AS AN EXTENSION CONSTRUCT OF UTAUT2

MyIndiHome is a mobile apps developed by Telkom with the hope that it will further improve the quality of service to IndiHome customers. This application can be used by customers for requests for new installations, complaints of service interruptions, requests for additional services, service checks, and others where previously this could be done by customers by calling 147 or coming physically to Plasa Telkom which certainly makes customers hassle and not simple. The purpose of this study is to evolve a research model based on the UTAUT2 and then to test it empirically to determine factors that influence customer' intention to use MyIndiHome apps. This study used an online questionnaire survey namely Google form to collect data from IndiHome customers who have installed MyIndiHome in Medan city and obtained 400 respondents who filled out the survey and were declared valid. The data were analyzed utilizing the PLS method with SmartPLS software. This study prescribed that habit, performance expectancy, customer mobility, and hedonic motivation were factors that determine on the behavioral intention of customers to use MyIndiHome and confirmed the relationship between behavior intention to use and use behavior was significant (p<0.05). However, customer’s behavioral intention to use MyIndiHome was not determined by social influence, effort expectancy, and facilitating condition. Additionally, this study revealed that facilitating condition did not determine the use of MyIndiHome (p>0.05).