Miracle-dz/UniFAR-FTUs huggingface dataset:
Determinan Pencegahan Kecurangan Dalam Alokasi Dana Desa

The purpose of this study is to find empirical evidence regarding the effect of competence, morality, integrity, internal control and organizational culture on the fraud prevention in allocation of village funds. The sample in this study are obtained from 148 respondents from village officials in Denpasar. Multiple regression analysis is used to answer the hypothesis in this study. The results of the study find that competence, morality, internal control and organizational culture has a positive effect on fraud prevention. This finding indicates that village officials have responsibilities and want to apply the good village governance principles, transparent, and accountable. Integrity was not able to minimize the occurrence of fraud. The allocation of village funds has a vulnerability in its allocation in infrastructure development in the village. This study uses organizational culture as novelty because there are few articles that examine the allocation of village funds with organizational culture. For further research is expected to examine the characteristics of village heads that can affect the level of fraud prevention in village funds. The village head as the user of village funds is expected to be transparent and responsible in the allocation of village funds.
Genomic Alterations, Gene Expression Profiles and Functional Enrichment of Normal-Karyotype Acute Myeloid Leukaemia Based on Targeted Next-Generation Sequencing

Simple Summary The characterisation of normal-karyotype acute myeloid leukaemia (AML-NK) requires further refinement based on genetic variations. In this study, we ascertained genomic biomarkers via DNA and RNA sequencing in eight AML-NK patients during diagnosis and after achieving complete remission. We discovered putative variants affecting gene regulation and functional enrichments dysregulating transcription and DNA-binding transcription activator activity RNA polymerase II-specific in our cohort. Abstract Characterising genomic variants is paramount in understanding the pathogenesis and heterogeneity of normal-karyotype acute myeloid leukaemia (AML-NK). In this study, clinically significant genomic biomarkers were ascertained using targeted DNA sequencing and RNA sequencing on eight AML-NK patients’ samples collected at disease presentation and after complete remission. In silico and Sanger sequencing validations were performed to validate variants of interest, and they were followed by the performance of functional and pathway enrichment analyses for overrepresentation analysis of genes with somatic variants. Somatic variants involving 26 genes were identified and classified as follows: 18/42 (42.9%) as pathogenic, 4/42 (9.5%) as likely pathogenic, 4/42 (9.5%) as variants of unknown significance, 7/42 (16.7%) as likely benign and 9/42 (21.4%) as benign. Nine novel somatic variants were discovered, of which three were likely pathogenic, in the CEBPA gene with significant association with its upregulation. Transcription misregulation in cancer tops the affected pathways involving upstream genes (CEBPA and RUNX1) that were deregulated in most patients during disease presentation and were closely related to the most enriched molecular function gene ontology category, DNA-binding transcription activator activity RNA polymerase II-specific (GO:0001228). In summary, this study elucidated putative variants and their gene expression profiles along with functional and pathway enrichment in AML-NK patients.
Patellofemoral Angle, Pelvis Diameter, Foot Posture Index, and Single Leg Hop in Post-Operative ACL Reconstruction

Background and Objectives: Anterior cruciate ligament (ACL) injuries occur as a result of the deterioration of the static and dynamic stability of the knee. One of the structures involved in providing static stability is the patellofemoral angle (Q angle). The aim of this study was to investigate the relationships between Q angle, pelvis diameter, lower extremity length, and foot posture index (FPI) in patients who had undergone ACL reconstruction (ACLR) with the semitendinosus/gracilis (ST/G) technique on both the operated and non-operated sides. Materials and Methods: Twenty-five male recreational athletic patients between the ages of 18 and 35 who had undergone semitendinosus/gracilis (ST/G) anterior cruciate ligament reconstruction at least 6 months earlier were included in the study. Femur length, lower extremity length, pelvis diameter, and Q angle measurements, total foot posture index (FPI) scores, and single leg hop (SLH) and triple hop distance (THD) test results were determined on the operated and non-operated sides. Results: When the findings of the patients were evaluated statistically between the operated and non-operated sides, no significant differences were found in Q angle, femur length, and lower extremity length (p > 0.05). In terms of FPI scores, a significant difference was found only in the inversion/eversion of the calcaneus (CALC) parameter (p < 0.05). When the single hop test (SLHT) results were evaluated statistically on the operated and non-operated sides, the results were in favor of the non-operated side (p < 0.05). In the correlation analysis conducted for both the operated and non-operated sides, positive and significant correlations were found only between SLH and THD (p < 0.05). No significant difference was found in the other parameters. Conclusions: The fact that ST/G ACLR 6th month post-operative findings revealed similar results in Q angle, lower extremity length, and total FPI scores between the operated and non-operated sides showed that the 6-month process did not cause a difference in these parameters. However, it was found that the operated sides showed lower findings compared to non-operated sides for SLHTs, although these findings were within normal ranges in terms of the limb symmetry index.
Semi-positone nonlocal boundary value problems of arbitrary order

We give a unified approach to the study of existence of multiple positive solutions for semi-positone boundary value problems of arbitrary order. We cover local and nonlocal boundary conditions. Our nonlocal boundary conditions are quite general, they involve positive linear functionals on the space $C[0,1]$, given by Stieltjes integrals. With our general theory, we can, for the first time in semi-positone problems, allow any number of the boundary conditions to be nonlocal.
Functional and structural alterations as diagnostic imaging markers for depression in de novo Parkinson’s disease

Background Depression in Parkinson’s disease (PD) is identified and diagnosed with behavioral observations and neuropsychological measurements. Due to the large overlaps of depression and PD symptoms in clinical manifestations, it is challenging for neurologists to distinguish and diagnose depression in PD (DPD) in the early clinical stage of PD. The advancement in magnetic resonance imaging (MRI) technology provides potential clinical utility in the diagnosis of DPD. This study aimed to explore the alterations of functional and structural MRI in DPD to produce neuroimaging markers in discriminating DPD from non-depressed PD (NDPD) and healthy controls (HC). Methods We recruited 20 DPD, 37 NDPD, and 41 HC matched in age, gender, and education years. The patients’ diagnosis with PD was de novo. The differences in regional homogeneity (ReHo), voxel-wise degree centrality (DC), cortical thickness, cortical gray matter (GM) volumes, and subcortical GM volumes among these groups were detected, and the relationship between altered indicators and depression was analyzed. Moreover, the receiver operating characteristic (ROC) analysis was performed to assess the diagnostic efficacy of altered indicators for DPD. Results Compared to NDPD and HC, DPD showed significantly increased ReHo in left dorsolateral superior frontal gyrus (DSFG) and DC in left inferior temporal gyrus (ITG), and decreased GM volumes in left temporal lobe and right Amygdala. Among these altered indicators, ReHo value in left DSFG and DC values in left ITG and left DSFG were significantly correlated with the severity of depression in PD patients. Comparing DPD and NDPD, the ROC analysis revealed a better area under the curve value for the combination of ReHo value in left DSFG and DC value in left ITG, followed by each independent indicator. However, the difference is not statistically significant. Conclusion This study demonstrates that both functional and structural impairments are present in DPD. Among them, ReHo value of left DSFG and DC value of left ITG are equally well suited for the diagnosis and differential diagnosis of DPD, with a combination of them being slightly preferable. The multimodal MRI technique represents a promising approach for the classification of subjects with PD.
Psychometric evaluation of the academic involution scale for college students in China: An application of Rasch analysis

Recent academic attention on educational involution in China underpins the need for a valid and reliable instrument to precisely measure college students’ academic involution behaviors. Seeing the scarcity of a proper instrument, the current study attempted to analyze the item-level psychometric properties of the newly developed Academic Involution Scale for College Students (AISCS) in China by using a Rasch model. A total of 637 college students in a public university in northern China participated in the study. Data were examined with respect to unidimensionality, rating scale functioning, item fit statistics, item polarity, item- and person-level reliability and separation, item hierarchy and invariance across educational background with Winsteps. The results show that AISCS was a single unidimensional construct with good psychometric properties. Although two items demonstrated differential item functioning, it is plausible given the differences between assessment methods for undergraduates and postgraduates. Limitations and future research directions with regard to sample selection, inclusion of more validity evidence and adding prospective additional academic involution were discussed.
Propagation of ULF waves through the ionosphere: Analytic solutions for oblique magnetic fields

[1] The propagation of ultra low frequency (ULF; 1-100 mHz) waves from the magnetosphere to the ground is examined in the presence of oblique background magnetic fields. The problem is developed analytically for a thin sheet ionosphere, neutral atmosphere, and perfectly conducting ground. The cold plasma, ideal magnetohydrodynamic (MHD) Alfven wave modes are assumed to propagate in the MHD medium above the ionosphere. A reflection and wave mode conversion coefficient matrix (RCM) is derived which describes mixing and conversion between shear Alfven and fast mode energy when interacting with the ionosphere/atmosphere/ground system. The RCM is found to depend in a complicated way on the background magnetic field dip angle, the horizontal wave vector, and the conductivity of the ionosphere. For an oblique background magnetic field, in the XZ plane, the perpendicular wave number, ky, is shown to be a critical parameter that determines reflection and mode conversion characteristics. This study also highlights the need for spatial information of ULF wave energy in order to interpret experimental ULF wave data recorded at ground level in terms of magnetospheric processes.
A nonreflecting outlet boundary condition for incompressible unsteady Navier-Stokes calculations

Abstract The goal of this work is to adapt a nonreflecting outlet boundary condition, derived from a wave equation, to the numerical solution of the full incompressible Navier-Stokes equations, for an elliptic unsteady free shear flow. The numerical results show that a significant improvement is achieved with this nonreflecting boundary condition, in comparison with the results obtained by using free boundary layer type conditions. The physical phenomena studied concern the onset of the Kelvin-Helmholtz instability in the free (non-forced) shear layer and certain 2D characteristics of transition towards turbulence. These phenomena are simulated naturally, without imposing perturbations. The frequency of the organized vortices and the spread of the mixing layer are correctly predicted. The performances of the method are shown through comparison with the physical experiments. Owing to the nonreflecting boundary conditions, the feedback noises are inhibited effectively, so that the computation domain can be reduced and the dynamic characteristics of the flow are maintained up clearly to the outlet boundary.
The Landscape of Lipid Metabolism in Lung Cancer: The Role of Structural Profiling

The aim of this study was to explore the relationship between lipids with different structural features and lung cancer (LC) risk and identify prospective biomarkers of LC. Univariate and multivariate analysis methods were used to screen for differential lipids, and two machine learning methods were used to define combined lipid biomarkers. A lipid score (LS) based on lipid biomarkers was calculated, and a mediation analysis was performed. A total of 605 lipid species spanning 20 individual lipid classes were identified in the plasma lipidome. Higher carbon atoms with dihydroceramide (DCER), phosphatidylethanolamine (PE), and phosphoinositols (PI) presented a significant negative correlation with LC. Point estimates revealed the inverse associated with LC for the n-3 PUFA score. Ten lipids were identified as markers with an area under the curve (AUC) value of 0.947 (95%, CI: 0.879–0.989). In this study, we summarized the potential relationship between lipid molecules with different structural features and LC risk, identified a panel of LC biomarkers, and demonstrated that the n-3 PUFA of the acyl chain of lipids was a protective factor for LC.
Comparison of Kalman-filter-based approaches for block matching in arterial wall motion analysis from B-mode ultrasound

Block matching (BM) has been previously used to estimate motion of the carotid artery from B-mode ultrasound image sequences. In this paper, Kalman filtering (KF) was incorporated in this conventional method in two distinct scenarios: (a) as an adaptive strategy, by renewing the reference block and (b) by renewing the displacements estimated by BM or adaptive BM. All methods resulting from combinations of BM and KF with the two scenarios were evaluated on synthetic image sequences by computing the warping index, defined as the mean squared error between the real and estimated displacements. Adaptive BM, followed by an update through the second scenario at the end of tracking, ABM_KF-K2, minimized the warping index and yielded average displacement error reductions of 24% with respect to BM. The same method decreased estimation bias and jitter over varying center frequencies by 30% and 64%, respectively, with respect to BM. These results demonstrated the increased accuracy and robustness of ABM_KF-K2 in motion tracking of the arterial wall from B-mode ultrasound images, which is crucial in the study of mechanical properties of normal and diseased arterial segments.
Antioxidant Potential of Tamarillo Fruits—Chemical and Infrared Spectroscopy Analysis

Native to South America, tamarillo (Solanum betaceum Cav.) is a small tree cultivated as a fruit crop in several regions of the world. Known for its sweet and sour taste, tamarillo fruits are very nutritious due to the presence of health-beneficial components such as fiber, vitamins, and antioxidants. Despite its nutritional value, tamarillo remains poorly known in global markets. The present work aims to study the antioxidant activity of four genotypes of tamarillo. Several chemical assays were performed to assess the antioxidant components and antioxidant activity of aqueous ethanolic extracts from each genotype. Overall, the Mealhada genotype (a red cultivar) showed the most interesting results, displaying the highest amount of total phenolic, flavonoids, and anthocyanin contents, as well as higher antioxidant activity. To evaluate the composition of the extract, Fourier-transform infrared spectroscopy (FTIR) was used to characterize important components in aqueous ethanolic extracts of the fruits, having revealed the presence of high amounts of phenols (the main compounds responsible for antioxidant activity), as well as triterpenoids and polysaccharides. The present results highlight the potential nutraceutical importance of tamarillo fruits.
Surface and Crustal Response to Deep Subduction Dynamics: Insights From the Apennines, Italy

The topography of orogenic belts responds to several contributions operating at short and long temporal and spatial (i.e., wavelengths) scales, from the surface to the deep mantle. Here, we aim to investigate the connection between morphometric characteristics, exhumation, and crustal deformation along and across the Italian Apennines, by comparing superficial with deeper data. Specifically, we present four sets of observations that are constructed by gathering previous data and adding new analyses and inferences, that include: (a) a new geomorphological set of analyses; (b) a database of available low temperature thermochronological cooling ages; (c) a reconstruction of drainage divide evolution in time and space based on the age of the youngest lacustrine deposits within each extensional basin; (d) Moho depth from receiver functions, gathering previous estimates and 13 new ones. From these sets of data, it emerges that across the main drainage divide of the Apennines, the morphological characteristics, the style of deformation and the spatial distribution of exhumation correlate with the geometries of the Moho and are associated with a strong asymmetry in the Northern‐Apennines and a clear symmetry in the Central‐Apennines. We interpret these results as evidence of a strong coupling between shallower and deeper geometries, that are most likely related to complex along‐strike variations in the Apennines geodynamic setting.
Modulation of the acute phase and metabolic response in feedlot steers supplemented with Saccharomyces cerevisiae subspecies boulardii CNCM 1-1079

Bovine respiratory disease (BRD) has a devastating economic impact on the beef industry. The annual estimated cost of BRD is well over $600 million. A possible way to mitigate the devastating effects of BRD is the supplementation of Saccharomyces cerevisiae. The supplementation of yeast has the potential to offset the impact of BRD due to its ability to alter the innate immune response, directly interact with pathogenic bacteria within the GIT tract, and/or through alteration of ruminant metabolism. To further evaluate yeast supplementation as a means to improve health, performance, and immunity in cattle, a receiving and immune challenge study was conducted to evaluate the effects of active dry yeast, Saccharomyces cerevisiae subspecies boulardii CNCM 1-1079 (SC; Lallemand, Inc.), in feedlot steers.
The Effects of Test Length and Sample Size on the Reliability and Equating of Tests Composed of Constructed-Response Items

Examined in this study were the effects of test length and sample size on the alternate forms reliability and the equating of simulated mathematics tests composed of constructed-response items scaled using the 2-parameter partial credit model. Test length was defined in terms of the number of both items and score points per item. Tests with 2, 4, 8, 12, and 20 items were generated, and these items had 2, 4, and 6 score points. Sample sizes of 200, 500, and 1,000 were considered. Precise item parameter estimates were not found when 200 cases were used to scale the items. To obtain acceptable reliabilities and accurate equated scores, the findings suggested that tests should have at least eight 6-point items or at least 12 items with 4 or more score points per item.
Balanced Incomplete Factorization

In this paper we present a new incomplete factorization of a square matrix into triangular factors in which we get standard $LU$ or $LDL^T$ factors (direct factors) and their inverses (inverse factors) at the same time. Algorithmically, we derive this method from the approach based on the Sherman-Morrison formula [R. Bru, J. Cerdan, J. Marin, and J. Mas, SIAM J. Sci. Comput. , 25 (2003), pp. 701-715]. In contrast to the robust incomplete decomposition (RIF) algorithm [M. Benzi and M. Tůma, Numer. Linear Algebra Appl. , 10 (2003), pp. 385-400] the direct and inverse factors here directly influence each other throughout the computation. Consequently, the algorithm to compute the approximate factors may mutually balance dropping in the factors and control their conditioning in this way. For the symmetric positive definite case, we derive the theory and present an algorithm for computing the incomplete $LDL^T$ factorization, and we discuss experimental results. We call this new approximate $LDL^T$ factorization the balanced incomplete factorization (BIF). Our experimental results confirm that this factorization is very robust and may be useful in solving difficult ill conditioned problems by preconditioned iterative methods. Moreover, the internal coupling of the computation of direct and inverse factors results in much shorter setup times (times to compute approximate decomposition) than RIF, a method of a similar and very high level of robustness. We also derive and present the theory for the general nonsymmetric case, but do not discuss its implementation.
Trends of axillary surgery in breast cancer patients with axillary lymph node metastasis: a comprehensive single-center retrospective study

Purpose Based on the results of previous trials, de-escalation of axillary surgery after neoadjuvant chemotherapy (NAC) has increased in patients with axillary lymph node (ALN) metastasis at presentation. This study aimed to review the trends of axillary surgery by time period and molecular subtype in patients with ALN metastasis. Methods We analyzed the rates of sentinel lymph node biopsy (SLNB) and ALN dissection (ALND) based on time period and subtype. The time period was divided into 3 subperiods to determine the rate of axillary surgery type over time (period 1, from 2009 to 2012; period 2, from 2013 to 2016; and period 3, from 2017 to July 2019). Results From 2009 to July 2019, 2,525 breast cancer patients underwent surgery. Based on subtype, the ALND rate of hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2–) disease decreased by 13.0% from period 1 to period 3 (period 1, 99.4%; period 2, 97.5%; and period 3, 86.4%; P < 0.001). Conversely, the ALND rate in HR+/HER2+, HR–/HER2+, and triple-negative breast cancer (TNBC) significantly decreased by 43.7%, 48.8%, and 35.2% in period 1, period 2, and period 3, respectively (P < 0.001). In the patient group receiving NAC, HR+/HER2– had a significantly higher ALND rate (84.1%) than HR+/HER2+, HR–/HER2+, and TNBC (60.8%, 62.3%, and 70.7%, respectively; P < 0.001). Conclusion The SLNB rate in patients with ALN metastasis has increased over time. However, the ALND rate in HR+/HER2– was significantly higher than in other subtypes.
Laminar Natural Convection Heat Transfer From Isothermal Cylinders With Active Ends

Calculation of free convection heat transfer from isothermal bodies of different shapes is of fundamental importance in science and engineering. In the present study, a new analytical model is developed to calculate laminar natural convection heat transfer from finite isothermal cylinders of arbitrary aspect ratio and orientation (vertical, horizontal, and inclined) with active ends in fluids of any Prandtl number. This method is based on the new concept of Dynamic Body Gravity Function. Also, a new dimensionless parameter called Body Fluid Function is introduced and applied in this method. Results of this dynamic model are presented for six different circular cylinders and compared with the available experimental data. Excellent agreement is found between the developed model and experimental results in a wide range of Rayleigh number for all cylinders discussed. This shows that the present method is a powerful tool for modeling laminar natural convection from isothermal bodies.