Miracle-dz/UniFAR-FTUs huggingface dataset:
Loss of a Premature Stop Codon in the Rice Wall-Associated Kinase 91 (WAK91) Gene Is a Candidate for Improving Leaf Sheath Blight Disease Resistance

Leaf sheath blight disease (SB) of rice caused by the soil-borne fungus Rhizoctonia solani results in 10–30% global yield loss annually and can reach 50% under severe outbreaks. Many disease resistance genes and receptor-like kinases (RLKs) are recruited early on by the host plant to respond to pathogens. Wall-associated receptor kinases (WAKs), a subfamily of receptor-like kinases, have been shown to play a role in fungal defense. The rice gene WAK91 (OsWAK91), co-located in the major SB resistance QTL region on chromosome 9, was identified by us as a candidate in defense against rice sheath blight. An SNP mutation T/C in the WAK91 gene was identified in the susceptible rice variety Cocodrie (CCDR) and the resistant line MCR010277 (MCR). The consequence of the resistant allele C is a stop codon loss, resulting in an open reading frame with extra 62 amino acid carrying a longer protein kinase domain and additional phosphorylation sites. Our genotype and phenotype analysis of the parents CCDR and MCR and the top 20 individuals of the double haploid SB population strongly correlate with the SNP. The susceptible allele T is present in the japonica subspecies and most tropical and temperate japonica lines. Multiple US commercial rice varieties with a japonica background carry the susceptible allele and are known for SB susceptibility. This discovery opens the possibility of introducing resistance alleles into high-yielding commercial varieties to reduce yield losses incurred by the sheath blight disease.
VALIDATION OF AATSR SSTs IN AUSTRALIAN WATERS

Over the past 15 years the three ATSR instruments have provided a near-continuous record of global sea surface temperatures that are now being actively used in climate research programs [1], [2]. The Australian Government has been a contributor to the design and construction of all three instruments, and has also been a strong supporter of the science program. As part of the UK-Australia collaboration CSIRO has been required to supply SST validation data for the continual assessment of the performance of the ATSR instruments. As the ATSR program has now progressed to the development of a long-term data set that provides a consistent estimate of the global SST it is important to re-visit the geophysical validation program for all three instruments. This will be necessary to ensure the longterm integrity of the climate data set. In this paper we present a summary of the Australian validation campaigns for ATSR and ATSR-2 as well as a detailed appraisal of the performance of the third instrument ‐ the AATSR. Comparisons are made between the pre-launch SST algorithm coefficients and those recently developed and used by ESA from December 2005.
Implementation of e-filing system and Indonesian tax payer compliance

This study was conducted in six tax service offices located throughout Lampung, namely Metro pratama tax service office, Bandar Lampung One pratama tax service office, Bandar Lampung Dua pratama tax service office, Natar pratama tax service office, Kotabumi pratama tax service office, and the Pratama Tax Service Office. Bandar Lampung Madya tax services. The purpose of this study was to determine the relationship between perceived ease of use of e-filing and individual taxpayer compliance in submitting annual tax returns and the quality of the e-filing system. return. review of the impact of individual taxpayer compliance in submitting annual notifications of perceptions of understanding the use of e-filing. hide the impact of the security and confidentiality of the electronic filing system on individual taxpayer compliance in longing for annual tax returns. With the aim of changing the magnitude of the influence between the variables studied, quantitative analysis research methods are used for research on certain populations or samples, data collection is carried out using instrument research, and data analysis is quantitative or statistical in nature. 300 people participated in this study through cluster random sampling as the sampling method. The software in this study is smartPLS, and the partial least squares (PLS) method is used to analyze the data. Individual taxpayer compliance is positively influenced by system quality, perceived convenience, perceived understanding, confidentiality, and security in the e-filing system.
Fault-Tolerant Hardware Acceleration for High-Performance Edge-Computing Nodes

High-performance embedded systems with powerful processors, specialized hardware accelerators, and advanced software techniques are all key technologies driving the growth of the IoT. By combining hardware and software techniques, it is possible to increase the overall reliability and safety of these systems by designing embedded architectures that can continue to function correctly in the event of a failure or malfunction. In this work, we fully investigate the integration of a configurable hardware vector acceleration unit in the fault-tolerant RISC-V Klessydra-fT03 soft core, introducing two different redundant vector co-processors coupled with the Interleaved-Multi-Threading paradigm on which the microprocessor is based. We then illustrate the pros and cons of both approaches, comparing their impacts on performance and hardware utilization with their vulnerability, presenting a quantitative large-fault-injection simulation analysis on typical vector computing benchmarks, and comparing and classifying the obtained results. The results demonstrate, under specific conditions, that it is possible to add a hardware co-processor to a fault-tolerant microprocessor, improving performance without degrading safety and reliability.
Evolution of the eastern Waddington thrust belt and its relation to the mid-Cretaceous Coast Mountains arc,

The eastern Waddington thrust belt cuts the eastern margin of the Coast Mountains mid-Cretaceous magmatic arc. Thrust faults carried Triassic rocks of the Intermontane superterrane, Early Cretaceous volcanic and clastic rocks, and volcanic and plutonic rocks of the active arc to the northeast, outward from the core of the arc. Minimum shortening across the thrust belt is estimated as 50% or 40 km. Synkinematic through postkinematic metamorphism produced an inverted metamorphic gradient with the structurally higher magmatic arc as the likely heat source. Radiometric, thermochronologic, and structural data indicate that the thrust belt was active at 84 Ma and probably at 87 Ma and suggest that the peak of postkinematic metamorphism occurred about 82–84 Ma. The thrust belt was intruded by postkinematic plutons in latest Cretaceous and early Tertiary time (68 Ma and 58 Ma). The eastern Waddington thrust belt is coeval with or slightly younger than a system of west directed thrusts in the western and southern parts of the Coast Mountains arc. The prominence of these structures suggests that synmagmatic contraction played a major role in development of the arc. The distribution and character of syn-and postthrusting metamorphism indicate that this contraction, rather than localized loading by magma, produced the metamorphism.
Are Upwelling Systems an Underestimated Source of Long Chain Omega‐3 in the Ocean? The Case of the Southern Benguela Upwelling System

The Benguela upwelling system (BUS) is one of the world's most productive ecosystems, supporting globally relevant fisheries. The BUS marine community is modulated by the availability of nutrients and omega‐3 long chain polyunsaturated fatty acid (hereafter, LC omega‐3). Phytoplankton growth in the BUS can be supported by upwelled nitrate, a new nitrogen (N) source to the surface, or by recycled N such as ammonium. Preferential assimilation of one N source over another may yield differences in LC omega‐3 production between high and low food‐quality species. To evaluate how upwelling and the N source(s) consumed by phytoplankton influence LC omega‐3 production, we sampled a BUS anchor station daily for 10 days. Upwelling on days 5–7 supplied high concentrations of nutrients to the surface, while pre‐ and post‐upwelling, surface waters were stratified and nutrient concentrations were low. LC omega‐3 and phytoplankton concentrations were near‐zero during upwelling, and elevated pre‐ and post‐upwelling. Throughout our sampling, nanoplankton (2.7–10 µm) dominated primary production (30–95%), relying mainly on nitrate to support their growth. Surface LC omega‐3 concentrations reached peaks of 215 and 175 µg L−1 pre‐ and post‐upwelling, up to 10 times higher than previous measurements from the BUS (<5 µg L−1). Pre‐upwelling, non‐diatom trophic markers (18:1n − 9, 18:4n − 3, 18:5n − 3) were dominant, with a switch over just two days to diatom trophic markers post‐upwelling (16:1n − 7, 16:2n − 4, 16:2n − 7, 16:3n − 4, 16:4n − 1). This study reveals the key role of upwelling in promoting phytoplankton LC omega‐3 production, which is tightly coupled to the supply of new nitrate. Additionally, the high observed LC omega‐3 concentrations suggest that global LC omega‐3 production is underestimated.
Beneficial Effects of Lactobacilli Species on Intestinal Homeostasis in Low-Grade Inflammation and Stress Rodent Models and Their Implication in the Modulation of the Adhesive Junctional Complex

Intestinal barrier integrity is essential in order to maintain the homeostasis of mucosal functions and efficient defensive reactions against chemical and microbial challenges. An impairment of the intestinal barrier has been observed in several chronic diseases. The gut microbiota and its impact on intestinal homeostasis is well described and numerous studies suggest the ability of some probiotic strains to protect the intestinal epithelial integrity and host homeostasis. In this work, we aimed to assess the beneficial effects of three Lactobacillus strains (Lacticaseibacillus rhamnosus LR04, Lacticaseibacillus casei LC03, and Lactiplantibacillus plantarum CNCM I-4459) and their mechanism of action in low-grade inflammation or neonatal maternal separation models in mice. We compared the impact of these strains to that of the well-known probiotic Lacticaseibacillus rhamnosus GG. Our results demonstrated that the three strains have the potential to restore the barrier functions by (i) increasing mucus production, (ii) restoring normal permeability, and (iii) modulating colonic hypersensitivity. Moreover, gene expression analysis of junctional proteins revealed the implication of Claudin 2 and Cingulin in the mechanisms that underlie the interactions between the strains and the host. Taken together, our data suggest that LR04, CNCM I-4459, and LC03 restore the functions of an impaired intestinal barrier.
effects of laser in situ keratomileusis (lasiK) on corneal biomechanical measurements with the Corvis sT tonometer

Purpose: This study was initiated to evaluate biomechanical changes using the Corvis ST tonometer (CST) on the cornea after laser in situ keratomileusis (LASIK). Setting: University Medical Center Hamburg-Eppendorf, Germany, and Care Vision Refractive Centers, Germany. Design: Retrospective cohort study. Methods: This retrospective study included 37 eyes of 37 refractive patients. All CST measurements were performed 1 day before surgery and at the 1-month follow-up examination. The LASIK procedure included mechanical flap preparation using a Moria SBK microkeratome and an Allegretto excimer laser platform. Results: Statistically significant differences were observed for mean first applanation length, mean first and second deflection lengths, mean first and second deflection amplitudes, radius of curvature, and peak distance. Significant positive correlations were found between the change ( Δ ) of radius of curvature and manifest refraction spherical equivalent (MRSE), ablation depth, and Δ intraocular pressure as well as between AD and Δ HC-time. Each diopter of myopic cor-rection in MRSE resulted in an increase in Δ radius of curvature of 0.2 mm. Conclusion: Several CST parameters were statistically significantly altered by LASIK, thereby indicating that flap creation, ablation, or both, significantly change the ability of the cornea to absorb or dissipate energy. peer-reviewed all subspecialties within ophthalmology. Key topics include: Optometry; Visual science; Pharmacology and drug therapy in eye diseases; Basic Sciences; Primary and Secondary eye care; Patient Safety and Quality of Care Improvements. on
Monitoring of Plasma EGFR Mutations during Osimertinib Treatment for NSCLC Patients with Acquired T790M Mutation

Simple Summary The sensitive PNA-LNA clamp method could highly detect EGFR gene mutations in plasma. Plasma clearance of the activating gene mutation and the T790M mutation was observed in more than 70% of patients treated with osimertinib, and its clearance was correlated with the efficacy of osimertinib treatment. The C797S mutation, an osimertinib resistance mutation, was detected in only 8.1% of osimertinib-resistant cases. Abstract Background: Osimertinib was first approved for the treatment of non-small cell lung cancer (NSCLC) in patients who have developed the epidermal growth factor receptor (EGFR) T790M mutation after treatment with EGFR tyrosine kinase inhibitors (TKIs). We routinely evaluated the plasma of NSCLC patients with the T790M mutation to more rapidly detect an increase in disease activity and resistance to treatment. Methods: Eligible patients received osimertinib after resistance to the first- or second-generation of EGFR-TKIs in NSCLC harboring T790M mutation detectable in tumor tissue or plasma. Plasma samples were collected every 8 weeks during osimertinib treatment. The plasma analysis was performed using an improved PNA-LNA PCR clamp method. We tested samples for a resistance mechanism, including EGFR-activating, T790M, and C797S mutations, and assessed the association between the mutations and osimertinib treatment. Results: Of the 60 patients enrolled in the study, 58 were eligible for this analysis. In plasma collected before osimertinib treatment, activating mutations were detected in 47 of 58 patients (81.0%) and T790M was detected in 44 patients (75.9%). Activating mutations were cleared in 60.9% (28/46) and T790M was cleared in 93.0% (40/43). Of these, 71.4% (20/28) of activating mutations and 87.5% (35/40) of T790M mutation were cleared within 8 weeks of treatment. The total response rate (RR) was 53.4% (31/58). The median duration of treatment was 259 days, with a trend toward longer treatment duration in patients who experienced the clearance of activating mutations with osimertinib. At the time of disease progression during osimertinib treatment, C797S was detected in 3 of 37 patients (8.1%). Conclusion: Plasma EGFR mutation analysis was effective in predicting the effect of osimertinib treatment.
Health Disparities in Advance Care Planning: Development of a Spanish-Language LEAD Guide (Life-Planning in Early Alzheimer's and Other Dementias)

Introduction: The LEAD (Life-Planning in Early Alzheimer's and Other Dementias) Guide is an advance care planning (ACP) tool for use within the context of dementia. To meet the needs of diverse communities, we sought to create a culturally sensitive and translated Latin American Spanish version of the guide. Methods: First, the guide was translated into Spanish. Second, we conducted forward and backward translations. Third, focus groups with Spanish-speaking Latino adults were held (healthy adults and current or previous dementia caregivers). Results: Descriptive analysis revealed three domains regarding the Latin American Spanish version of the LEAD Guide (LA LEAD Guide): (1) Family Dynamics (e.g., preventing family conflict), (2) Cultural Expectations (e.g., familial caregiving responsibility), and (3) Health Literacy (e.g., lack of knowledge about ACP). Discussion: This process created the Latin American LEAD Guide as a culturally and linguistically appropriate and acceptable ACP tool for older Latino adults. Health Equity Implications: The availability of culturally sensitive and Spanish ACP resources could facilitate greater health care access and research participation among Latino Americans by diminishing the linguistic and health literacy barriers for those not comfortably proficient in English.
Evaluation of a non-chemical IPM module for management of brinjal shoot and fruit borer.

Brinjal, Solanum melongena L. suffers from a substantial yield loss due to attack of brinjal shoot and fruit borer Leucinodes orbonalis Guene. The farmers mostly rely on insecticides which is detrimental to environment and increase the chances of residue in fruits. Keeping this in view, an attempt has been made to evaluate an IPM module for effective management of BSFB with four components viz., (i) application of neem cake @ 100 kg per acre in 2 splits i.e. @ 50 kg at the time of each of land preparation and 3 weeks after transplanting (ii) installation of pheromone traps @ 25-30 per acre starting from flower bud initiation till final harvest and changing of lures at monthly intervals for mass trapping of the pest (iii) mechanical clipping of the infested terminal shoots at weekly intervals and (iv) spraying of neem oil (Multineem) at an interval of 10-12 days.
TKE Budget in The Convective Martian PBL

Values for the different terms involved in the equation of the evolution of the Turbulent Kinetic Energy (TKE) will be derived in the Convective Planetary Boundary Layer of Mars. This will be done at the most convective hours (close to noon) both for the Surface Layer and for the Mixed Layer. Data-inputs employed to perform this study belong to the Vikings and Pathfinder landing sites. Specifically, Sols 27, 28, and 35 for the Viking Lander 1, and Sols 20 and 25 for the Viking Lander 2 have been chosen, whereas for the Pathfinder site it has only been selected Sol 25. Hourly in situ temperature and hourly in situ horizontal wind speed have been used, as well as simulated ground temperature (obtained by a selfmodification of [1]). These all correspond to typical low mid latitudes northern summer time conditions, and thus the results of this work are representative of such conditions.
Development and evaluation of a risk prediction model for diabetes mellitus type 2 patients with vision-threatening diabetic retinopathy

Objective This study aims to develop and evaluate a non-imaging clinical data-based nomogram for predicting the risk of vision-threatening diabetic retinopathy (VTDR) in diabetes mellitus type 2 (T2DM) patients. Methods Based on the baseline data of the Guangdong Shaoguan Diabetes Cohort Study conducted by the Zhongshan Ophthalmic Center (ZOC) in 2019, 2294 complete data of T2DM patients were randomly divided into a training set (n=1605) and a testing set (n=689). Independent risk factors were selected through univariate and multivariate logistic regression analysis on the training dataset, and a nomogram was constructed for predicting the risk of VTDR in T2DM patients. The model was evaluated using receiver operating characteristic (ROC) curves and area under the curve (AUC) in the training and testing datasets to assess discrimination, and Hosmer-Lemeshow test and calibration curves to assess calibration. Results The results of the multivariate logistic regression analysis showed that Age (OR = 0.954, 95% CI: 0.940-0.969, p = 0.000), BMI (OR = 0.942, 95% CI: 0.902-0.984, p = 0.007), systolic blood pressure (SBP) (OR =1.014, 95% CI: 1.007-1.022, p = 0.000), diabetes duration (10-15y: OR =3.126, 95% CI: 2.087-4.682, p = 0.000; >15y: OR =3.750, 95% CI: 2.362-5.954, p = 0.000), and glycated hemoglobin (HbA1C) (OR = 1.325, 95% CI: 1.221-1.438, p = 0.000) were independent risk factors for T2DM patients with VTDR. A nomogram was constructed using these variables. The model discrimination results showed an AUC of 0.7193 for the training set and 0.6897 for the testing set. The Hosmer-Lemeshow test results showed a high consistency between the predicted and observed probabilities for both the training set (Chi-square=2.2029, P=0.9742) and the testing set (Chi-square=7.6628, P=0.4671). Conclusion The introduction of Age, BMI, SBP, Duration, and HbA1C as variables helps to stratify the risk of T2DM patients with VTDR.
CORONARY ARTERY DISEASE Original Studies Real-World Bare Metal Stenting: Identification of Patients at Low or Very Low Risk of 9-Month Coronary Revascularization

The high cost of drug-eluting stents (DESs) has made identification of patients who are at low risk for subsequent revascularization after treatment with bare metal stents (BMSs) highly desirable. Previous reports from randomized trials suffer from biases induced by restricted entry criteria and protocol-mandated angiographic follow-up. Between 1994 and 2001, 5,239 consecutive BMS patients, excluding those with coil stents, technical failure, brachytherapy, staged procedure, or stent thrombosis within 30 days, were prospectively identified from a large single-center tertiary-referral-center prospective registry for long-term follow-up. We sought to identify characteristics of patients with very low (≤ 4%) or low (4–10%) likelihood of coronary revascularization 9 months after BMS. Nine-month clinical follow-up was obtained in 98.2% of patients. Coronary revascularization was required in 13.4% and did not differ significantly by stent type. On the basis of multivariate analysis identifying 11 independent correlates and previous reports, 20 potential low-risk patient and lesion groups (228 356 patients/groups) were identified (e.g, patients with all of the following: native vessel, de novo, reference diameter ≥ 3.5 mm, lesion length < 5 mm, no diabetes, not ostial in location). Actual and model-based outcomes were analyzed. No group had both predicted and observed 9-month revascularization ≤ 4% (very low risk). Conversely, 19 of 20 groups had a predicted and observed revascularization rate of 4–10% (low risk). In the real-world setting, the need for intermediate-term revascularization after BMS may be lower than expected, but it may be very difficult to identify patients at very low risk. Conversely, if the benefits of DESs are attenuated in routine practice, many groups of patients treated with BMSs may have nearly comparable results. Catheter Cardiovasc Interv 2004;63: 135–140. © 2004 Wiley-Liss, Inc.
CORONARY ARTERY DISEASE Original Studies Clinical Validation of the New T- and Y-Shape Models for the Quantitative Analysis of Coronary Bifurcations: An Interobserver Variability Study

Objectives: This article presents the results of an interobserver validation study of our new Tand Y-shape bifurcation models including their edge segment analyses. Background: Over the last years, the coronary artery intervention procedures have been developed more and more toward bifurcation stenting. Because traditional straight vessel quantitative coronary arteriography (QCA) is not sufficient for these measurements, the need has grown for new bifurcation analysis methods. Methods: In this article, our two new bifurcation analysis models are presented, the Y-shape and T-shape model. These models were designed for the accurate measurement of the clinically relevant parameters of a coronary bifurcation, for different morphologies and intervention strategies and include an edge segment analysis, to accurately measure (drug-eluting) stent, stent edge, and ostial segment parameters. Results: The results of an interobserver validation study of our T-shape and Y-shape analyses are presented, both containing the preand post-intervention analyses of each 10 cases. These results are associated with only small systematic and random errors, in the majority of the cases compliant with the QCA guidelines for straight analyses. The results for the edge segment analyses are also very good, with almost all the values within the margins that have been set by our brachytherapy directive. Conclusions: Our new bifurcation approaches including their edge segment analyses are very robust and reproducible, and therefore a great extension to the field of quantitative coronary angiography. VC 2012 Wiley Periodicals, Inc.