Miracle-dz/UniFAR-FTUs huggingface dataset:
The Sappanwood Extract Drying With Carrier Agent Under Air Dehumidification

The sappanwood extract enriched by brazilin can be used for natural colouring agent in food and beverages. The extract is produced in form of dry powder for consummer convenience as well as prolonging storage life. Currently, the sappanwood extract drying still deals with the product sticky that inhibit water transport in drying. As a result, the drying process needs long time to get moisture content below 10%. The extract drying with carrier agent is an option to break the product sticky and to enlarge the surface area for water transport. This paper discusses the effect of carrier agent arabic gum and maltodextrin on sappanwood extract drying with air dehumidification. As a responses, the moisture content in extract was observed every sampling time and average drying rate was estimated. Results showed that, the carrier agent improve drying rate significantly. With arabic gum 10%, the average drying time can be 2 hours shorter than that of without carrier agent. With faster drying rate, the drying time was shorter at higher operational temperature. Keywords: Brazilin, dehumidification, tray dryer, zeolite
Cross-cultural adaptation, reliability, and validity of the work role functioning questionnaire 2.0 to Persian

Abstract Purpose To translate and cross-culturally adapt, the Work Role Functioning Questionnaire 2.0 to Persian (WRFQ-Pr), and evaluate reliability and validity. Material and Methods Standardized protocols were followed including forward-backward translation then synthesis/consolidation. Subsequent pilot investigation of the draft WRFQ-Pr (n = 50, male = 68%, age = 33.5 ± 7.3 years) tested the alternative wording and determined face and content validity through readability, understandability, interpretation, and cultural relevance. Participants (n = 288) were recruited from a convenience sample to assess: construct validity through exploratory factor analysis (EFA) using Promax rotation and maximum least squares extraction; and internal consistency using Cronbach’s α coefficient. Test-retest reliability was evaluated from the intraclass correlation coefficient (ICC2.1). Results The forward-backward translation was achieved with eight items (1,3,4,5,9,11,12,22) modified and reformulated due to idiomatic issues. Internal consistency for the subscales ranged from α = 0.87–0.95, and the test-retest reliability was ICC(2,1)=0.92 (CI: 0.89–0.95). The EFA showed a four-factor solution, being identical to the original version, however items 20–22 loaded with items 23–26 in one factor, which was re-named “flexibility and social demand. ” One item (#26) did not load above the required 0.30 threshold and was removed from the WRFQ-Pr. No floor or ceiling effects were found. Conclusions The WRFQ translation and cross-cultural adaptation to Persian (WRFQ-Pr) was performed successfully. The determined properties of reliability and validity were comparable to those of the original English version. IMPLICATIONS FOR REHABILITATION The WRFW can simultaneously evaluate the health status of the worker, the existence of impairments, the involved factors in creating ability/disability at work, and the outcome of the interventions. There is no instrument available for the Persian-speaking population to evaluate related disability at work and the condition of return to work after a rehabilitation intervention. The WRFQ was translated and culturally adapted into Persian. The WRFW-Pr demonstrated excellent internal consistency, test-retest reliability and a four-factor structure.
Association of blood lead level with vitamin D binding protein, total and free 25-hydroxyvitamin D levels in middle-school children

Abstract A negative association between blood Pb level (BPbL) and vitamin D metabolites in occupationally exposed populations has been reported, but data from the general population are scarce. Furthermore, the association between BPbL and vitamin D binding protein (DBP) and free 25-hydroxyvitamin D (25(OH)D) has not been reported. We investigated the association of BPbL with DBP, total and free 25(OH)D in healthy adolescents (n 1347; age range 11–16 years) cross-sectionally selected from all Governorates of Kuwait, utilising multi-stage cluster random sampling. Pb in whole blood was analysed by inductively coupled plasma MS, and DBP with ELISA. Plasma 25(OH)D was analysed by LC-MS/MS, and free 25(OH)D was calculated utilising the levels and binding affinities of DBP and albumin for 25(OH)D. DBP was positively associated with BPbL (β = 0·81; 95 % CI 0·14, 0·22; P < 0·001). A negative association between BPbL and total 25(OH)D was non-significant (P = 0·24) when BPbL was used as a continuous variable but was significant when used as quartiles (P = 0·02). The negative association between BPbL and free 25(OH)D was significant whether BPbL was used as continuous, as quartiles or as cut-off point of <5 µg/dl (0·24 µmol/l). In multinomial logistic regression, the odds of vitamin D insufficiency and deficiency were more than two-fold higher in the upper quartiles of BPbL compared with the lowest quartile. The negative correlation of BPbL with free 25(OH)D was more robust than its correlation with total 25(OH)D. Future studies must consider the levels of DBP when assessing the association between Pb and vitamin D metabolites.
Rice stripe virus: Exploring Molecular Weapons in the Arsenal of a Negative-Sense RNA Virus.

Rice stripe disease caused by Rice stripe virus (RSV) is one of the most devastating plant viruses of rice and causes enormous losses in production. RSV is transmitted from plant to plant by the small brown planthopper (Laodelphax striatellus) in a circulative-propagative manner. The recent reemergence of this pathogen in East Asia since 2000 has made RSV one of the most studied plant viruses over the past two decades. Extensive studies of RSV have resulted in substantial advances regarding fundamental aspects of the virus infection. Here, we compile and analyze recent information on RSV with a special emphasis on the strategies that RSV has adopted to establish infections. These advances include RSV replication and movement in host plants and the small brown planthopper vector, innate immunity defenses against RSV infection, epidemiology, and recent advances in the management of rice stripe disease. Understanding these issues will facilitate the design of novel antiviral therapies for management and contribute to a more detailed understanding of negative-sense virus-host interactions at the molecular level. Expected final online publication date for the Annual Review of Phytopathology, Volume 59 is August 2021. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Tracking COVID-19 vaccine hesitancy and logistical challenges: A machine learning approach

In this study, we use an effective word embedding model (word2vec) to systematically track ’vaccine hesitancy’ and ’logistical challenges’ associated with the Covid-19 vaccines, in the USA. To that effect, we use news articles from reputed media sources and create dictionaries to estimate different aspects of vaccine hesitancy and logistical challenges. Using machine learning and natural language processing techniques, we have developed (i) three sub-dictionaries that indicate vaccine hesitancy, and (ii) another dictionary for logistical challenges associated with vaccine production and distribution. Vaccine hesitancy dictionaries capture three aspects: (a) general vaccine related concerns, mistrusts, skepticisms, and hesitancy, (b) discussions on symptoms and side-effects, and (c) discussions on vaccine related physical effects. The dictionary on logistical challenges includes the words and phrases related to the production, storage, and distribution of vaccines. Our results show that over time, as vaccine developers complete different phase trials and get approval for their respective vaccines, the number of vaccine related news articles increases sharply. Accordingly, we also see a sharp increase in vaccine hesitancy related topics in news articles. However, in January 2021, there has been a decrease in the vaccine hesitancy score, which will give some relief to the health administrators and regulators. Our findings further show that as we get closer to the breakthrough of effective Covid-19 vaccines, new logistical challenges continue to rise, even in recent months.
Cognitive performance in older adults at three months following mild traumatic brain injury

ABSTRACT Introduction: In the context of limited research assessing outcomes following mild traumatic brain injury (mTBI) in older adults, this study evaluated cognitive outcomes through prospective memory, and expected that performance of an older mTBI group (≥65 years) would be lower compared to orthopedic and community controls. The study also explored whether cognitive resources (retrospective memory, executive function) moderated any association between presenting Glasgow Coma Scale (GCS) and prospective memory. Method: At three-months post-injury, a mTBI group (n = 39), an orthopedic control group (n = 63), and a community control group (n = 46) completed a neuropsychological assessment, including (i) prospective memory, using a standardized paper-and-pencil task (Cambridge Prospective Memory Test), an augmented reality task and a naturalistic task, and (ii) standardized measures of retrospective memory (Hopkins Verbal Learning Test) and executive function (Trail Making Test). Group performances were compared, and bootstrapped moderation analyses evaluated the role of cognitive resources in the relationship between GCS and prospective memory outcome. Results: The mTBI group, as compared to community controls, performed significantly lower on the augmented reality task (d = −0.64 to d = −0.79), and there was a small-moderate but non-significant effect (d = −0.45) on the naturalistic task. There were no differences between the mTBI group and orthopedic controls. Retrospective memory was a unique predictor of the augmented reality task (B = 1.83) and moderated the relationship between presenting GCS and the naturalistic task (B = −5.60). Executive function moderated the association between presenting GCS and augmented reality (B = −1.13) and naturalistic task (B = −1.57). Conclusions: At three-months post-mTBI, older adults are at risk of poor cognitive performance; and the relationship between GCS and prospective memory can be moderated by cognitive resources. Further follow-up is indicated to determine whether impairments resolve or persist over time.
Voice, Counterspaces, and Ethical Care in Research With Black Women With Trauma and Incarceration Histories

Formerly incarcerated women face diverse challenges to re-entry, which include recovering from health illnesses and trauma to navigating various systems of stigma and surveillance. It is these multilevel challenges to reintegration that also make formerly incarcerated women vulnerable participants in research. As such, this qualitative study explores how 28 formerly incarcerated Black women experience the research interview process. Findings revealed that women participated in research because these contexts were viewed as spaces for “truth telling” and increasing awareness that can effect changes in the lives of communities facing trauma. Moreover, the participants perceived the interview process to allow them to share their pasts in ways that can promote healing and recovery. Participants also discussed risks of emotional distress and anticipatory fears regarding imbalanced researcher–participant dynamics. The implications for antioppressive, compassionate interviewing practices underscore the need for greater considerations of the role of the researcher and how they contribute to women’s recovery from complex trauma and illness.
Early prenatal use of a multivitamin diminishes the risk for inadequate vitamin D status in pregnant women: results from the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort study

ABSTRACT Background Reports on the adequacy of vitamin D status of pregnant women are not available in Canada. Objectives The objectives of this study were to examine vitamin D status across pregnancy and identify the correlates of vitamin D status of pregnant women in Canada. Methods Pregnant women (≥18 years) from 6 provinces (2008–2011) participating in a longitudinal cohort were studied. Sociodemographic data, obstetrical histories, and dietary and supplemental vitamin D intakes were surveyed. Plasma 25-hydroxyvitamin D (25OHD) was measured using an immunoassay standardized to LC-MS/MS from samples collected during the first (n = 1905) and third trimesters (n = 1649) and at delivery (n = 1543). The proportion of women with ≥40 nmol/L of plasma 25OHD (adequate status) was estimated at each time point, and factors related to achieving this cut point were identified using repeated-measures logistic regression. Differences in 25OHD concentrations across trimesters and at delivery were tested a using repeated-measures ANOVA with a post hoc Tukey's test. Results In the first trimester, 93.4% (95% CI: 92.3%–94.5%) of participants had 25OHD ≥40 nmol/L. The mean plasma 25OHD concentration increased from the first to the third trimester and then declined by delivery (69.8 ± 0.5 nmol/L, 78.6 ± 0.7 nmol/L, and 75.7 ± 0.7 nmol/L, respectively; P < 0.0001). A lack of multivitamin use early in pregnancy reduced the odds of achieving 25OHD ≥40 nmol/L (ORadj = 0.33; 95% CI: 0.25–0.42) across all time points. Factors associated with not using a prenatal multivitamin included multiparity (ORadj = 2.08; 95% CI: 1.42–3.02) and a below-median income (ORadj = 1.39; 95% CI: 1.02–1.89). Conclusions The results from this cohort demonstrate the importance of early multivitamin supplement use to achieve an adequate vitamin D status in pregnant women.
Dysbiosis in the Salivary Microbiome Associated with IgA Nephropathy—A Japanese Cohort Study

IgA nephropathy is one of the leading causes of chronic kidney disease in Japan. Since the origin and mechanisms by which IgA nephropathy develops currently remain unclear, a confirmed disease diagnosis is currently only possible by highly invasive renal biopsy. With the background of the salivary microbiome as a rich source of biomarkers for systemic diseases, we herein primarily aimed to investigate the salivary microbiome as a tool for the non-invasive diagnosis of IgA nephropathy. In a comparison of salivary microbiome profiles using 16S rRNA amplicon sequencing, significant differences were observed in microbial diversity and richness between IgA nephropathy patients and healthy controls. Furthermore, recent studies reported that patients with IgA nephropathy are more likely to develop inflammatory bowel diseases and that chronic inflammation of the tonsils triggered the recurrence of IgA nephropathy. Therefore, we compared the salivary microbiome of IgA nephropathy patients with chronic tonsillitis and ulcerative colitis patients. By combining the genera selected by the random forest algorithm, we were able to distinguish IgA nephropathy from healthy controls with an area under the curve (AUC) of 0.90, from the ulcerative colitis group with AUC of 0.88, and from the chronic tonsillitis group with AUC of 0.70. Additionally, the genus Neisseria was common among the selected genera that facilitated the separation of the IgA nephropathy group from healthy controls and the chronic tonsillitis group. The present results indicate the potential of the salivary microbiome as a biomarker for the non-invasive diagnosis of IgA nephropathy.
Fluorescent-detected retrotranslocation of an endoplasmic reticulum - associated degradation (ERAD) substrate in a mammalian in vitro system

Fluorescent-Detected Retrotranslocation of an Endoplasmic Reticulum-Associated Degradation (ERAD) Substrate in a Mammalian In Vitro System. (December 2007) Judit Wahlman, B.S., University of Western Ontario Chair of Advisory Committee: Dr. Arthur E. Johnson Secretory proteins that are unable to assemble into native proteins in the endoplasmic reticulum (ER) are transported back into the cytosol for degradation. Many cytosolic and ER resident proteins have been identified so far as being involved in this retrotranslocation process, but it is difficult to determine whether these proteins have a direct or indirect effect. Interpretations are further complicated if the loss of a specific protein is obscured by the presence of another protein that is partially or wholly redundant. To overcome these limitations, a mammalian in vitro system was developed that allowed to monitor retrotranslocation synchronously and in real time in the absence of concurrent translocation. To examine the roles of different components in ER-associated degradation (ERAD), well-defined and homogeneous mammalian ER microsomes were prepared biochemically by encapsulating a fluorescent-labeled ERAD substrate with specific lumenal components. After mixing ATP, specific cytosolic proteins, and specific fluorescence quenching agents with microsomes, substrate retrotranslocation was initiated. The rate of substrate efflux from microsomes was monitored spectroscopically
COVID-19: Seroprevalence and Vaccine Responses in UK Dental Care Professionals

Dental care professionals (DCPs) are thought to be at enhanced risk of occupational exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, robust data to support this from large-scale seroepidemiological studies are lacking. We report a longitudinal seroprevalence analysis of antibodies to SARS-CoV-2 spike glycoprotein, with baseline sampling prior to large-scale practice reopening in July 2020 and follow-up postimplementation of new public health guidance on infection prevention control (IPC) and enhanced personal protective equipment (PPE). In total, 1,507 West Midlands DCPs were recruited into this study in June 2020. Baseline seroprevalence was determined using a combined IgGAM enzyme-linked immunosorbent assay and the cohort followed longitudinally for 6 mo until January/February 2021 through the second wave of the coronavirus disease 2019 pandemic in the United Kingdom and vaccination commencement. Baseline seroprevalence was 16.3%, compared to estimates in the regional population of 6% to 7%. Seropositivity was retained in over 70% of participants at 3- and 6-mo follow-up and conferred a 75% reduced risk of infection. Nonwhite ethnicity and living in areas of greater deprivation were associated with increased baseline seroprevalence. During follow-up, no polymerase chain reaction–proven infections occurred in individuals with a baseline anti–SARS-CoV-2 IgG level greater than 147.6 IU/ml with respect to the World Health Organization international standard 20-136. After vaccination, antibody responses were more rapid and of higher magnitude in those individuals who were seropositive at baseline. Natural infection with SARS-CoV-2 prior to enhanced PPE was significantly higher in DCPs than the regional population. Natural infection leads to a serological response that remains detectable in over 70% of individuals 6 mo after initial sampling and 9 mo from the peak of the first wave of the pandemic. This response is associated with protection from future infection. Even if serological responses wane, a single dose of the Pfizer-BioNTech 162b vaccine is associated with an antibody response indicative of immunological memory.
A survey of animal poisonings in New Zealand veterinary practices: perceptions of incidence and frequency of poisoning cases

ABSTRACT Aims To survey New Zealand veterinary practices on the incidence and frequency of animal poisonings encountered over a 1-year period. Methods A national questionnaire-based cross-sectional online survey was made available to all members of the New Zealand Veterinary Association, active as of 2010, via an email supplying a link to the questionnaire. Veterinary practices listed by the Veterinary Council of New Zealand were also contacted via email or phone. Respondents entered their information on the online survey site or provided a hard copy of their responses, which were then entered by the authors into the database. The questionnaire contained a mixture of tick box options and short answer questions. Responses were analysed using descriptive statistics. Results Of 463 veterinary practices deemed eligible to complete the survey, 120 (25.9%) responded to the survey. However, only 94 (78.3%) questionnaire entries (78.3%) were deemed adequate for analysis. Veterinary practices (45 mixed practices, 38 companion animal-only practices, nine large animal practices, and two equine-only practices) from 14/16 regions of New Zealand were represented. All respondents affirmed that in the last 12 months, cases of suspected poisoning in animals were attended by veterinarians at their practices and estimated a total of 5,326 poisoning cases. The subcategories most commonly associated with estimated cases of poisoning were pasture mycotoxins (2,133/5,326; 40%), anticoagulant rodenticides (753/5,326; 14.1%), plants (469/5,326; 8.8%), slug/snail baits (305/5,326; 5.7%) and chocolate (221/5,326; 4.1%). Except for anticoagulant rodenticides (once a month), and slug/snail baits, human prescription or over-the-counter drugs, and chocolate (once a year), the majority of respondents reported toxicants caused poisonings seasonally or infrequently. Conclusions A variety of poisons were encountered with environmental toxins and household pest control agents being the most common cause of poisoning for animals attended by veterinarians in New Zealand. Most cases of poisoning in animals occurred seasonally or infrequently. Further research is needed to determine the actual number of animals poisoned, the affected species, and the seasons when poisoning occurs in New Zealand. Clinical relevance : This report provides baseline information on cases of poisoning in animals in New Zealand which could be used for case management, prevention through client education, and poisoning risk assessment.
Self-Care Practices Among Adult Type 2 Diabetes Patients With and Without Peripheral Neuropathy: A Cross-Sectional Study at Tertiary Healthcare Settings in Ethiopia

Background Type 2 diabetes mellitus (T2D) has become a global health challenge. Diabetic peripheral neuropathy (DPN) is one of the common comorbidities of T2D that may affect the ability to perform diabetes self-care. Purpose To compare self-care practices between adult T2D patients with and without comorbid DPN and identify factors predicting self-care practices. Methods In this cross-sectional study, conducted at tertiary hospitals in Ethiopia, a total of 216 (108 with DNP and 108 without DNP) participants completed an interviewer-administered questionnaire including measures of diabetes self-care practices, self-evaluated peripheral neuropathy, self-efficacy, diabetes knowledge, and social support. Results Adult T2D patients with comorbid DPN had lower dietary (P< 0.001), exercise (P< 0.001), blood glucose testing (P = 0.001), and foot (P = 0.007) self-care practice than those without DPN. Social support is a significant predictor of dietary self-care in both groups while predicting foot self-care and blood glucose testing in those with comorbid DPN. Moreover, occupation, education, and having a glucometer are significant predictors of diabetes self-care practice in both groups. Conclusion This study found that adult T2D patients with comorbid DPN have poorer diabetes self-care practice than those without comorbid DPN. Interventions should focus on addressing social support and access to a glucometer in order to improve diabetes self-care practices in adult T2D patients with comorbid DPN.