Miracle-dz/UniFAR-FTUs huggingface dataset:
A randomized controlled trial of comparative effectiveness of elastic therapeutic tape, sham tape or eccentric exercises alone for lateral elbow tendinosis

Introduction Lateral elbow tendinosis is a condition that is well known to cause difficult challenges for hand therapists due to its long-term recovery and morbidity. Elastic therapeutic tape is commonly used as a treatment modality, despite limited evidence. Methods A randomized controlled trial was conducted to evaluate the effectiveness of elastic therapeutic tape, in conjunction with eccentric exercises, in the treatment of lateral elbow tendinosis. Forty participants with this condition (12 men, 28 women) were randomly allocated to three groups: (i) elastic therapeutic tape and eccentric exercises, (ii) sham tape and eccentric exercises, and (iii) eccentric exercises alone. All groups received education on activity modification techniques. Interventions were undertaken over a 12-week period (four weekly sessions and four fortnightly sessions) and outcome measures were recorded at baseline, three months and six months post randomisation. Results At three and six months, improvements were made in all three groups as assessed with the Patient-Rated Tennis Elbow Evaluation, the Short Form 36, pain-free grip strength, and the Occupational Self Assessment. However, there were no statistically significant differences between groups in any of these measures. There were no significant side effects or symptom exacerbation with using the elastic therapeutic tape. Conclusions Whilst all groups improved on key outcomes, it is possible that exercise alone and/or natural recovery were responsible for improvements. It is positive to note that the use of elastic therapeutic tape was well tolerated by participants and not associated with any significant side effects or symptom exacerbation.
Success in English Medium Instruction in China: significant indicators and implications

ABSTRACT This article reports a mixed-methods study that investigates academic success in English Medium Instruction (EMI) at a Chinese state university. Questionnaire, exam score (n = 100), and semi-structured interview data (n = 29) was collected from second-year undergraduate students majoring in Business Management. Content-related language proficiency, perceived success, and motivation were explored as possible significant predictors of academic success in EMI. Business English proficiency was a statistically significant predictor, highlighting that students with a lower level of proficiency need supplementary linguistic support in order to fully succeed in their EMI studies. Language learning motivation did not predict academic success, echoing previous findings (Rose, H., S. Curle, I. Aizawa, and G. Thompson. 2019. “What drives success in English medium taught courses? ” The interplay between language proficiency, academic skills, and motivation. Studies in Higher Education 0 (0): 1–13. doi:10.1080/03075079.2019. 1590690). Perceived success in EMI did predict actual success in EMI, highlighting the need to enhance students’ perceptions of their own ability to succeed in EMI. Qualitative data revealed that students’ perceptions of success in EMI centred around content knowledge acquisition, improved English proficiency, knowledge application and transformation, and forming new modes of thinking. Practical implications for pedagogy are discussed.
Rapamycin rejuvenates oral health in aging mice

Periodontal disease is an age-associated disorder clinically defined by periodontal bone loss, inflammation of the specialized tissues that surround and support the tooth, and microbiome dysbiosis. Currently, there is no therapy for reversing periodontal disease, and treatment is generally restricted to preventive measures or tooth extraction. The FDA-approved drug rapamycin slows aging and extends lifespan in multiple organisms, including mice. Here we demonstrate that short-term treatment with rapamycin rejuvenates the aged oral cavity of elderly mice, including regeneration of periodontal bone, attenuation of gingival and periodontal bone inflammation, and revertive shift of the oral microbiome toward a more youthful composition. This provides a geroscience strategy to potentially rejuvenate oral health and reverse periodontal disease in the elderly. Single Sentence Summary Short-term treatment with rapamycin reverses periodontal bone loss, attenuates inflammation, and remodels the oral microbiome toward a more youthful state.
Numerical Study of the Interaction between Oasis and Urban Areas within an Arid Mountains-Desert System in Xinjiang, China

The rapid oasis expansion and urbanization that occurred in Xinjiang province (China) in the last decades have greatly modified the land surface energy balance and influenced the local circulation under the arid mountains-plain background system. In this study, we first evaluated the ALARO regional climate model coupled to the land surface scheme SURFEX at 4 km resolution using 53 national climatological stations and 5 automatic weather stations. We found that the model correctly simulates daily and hourly variation of 2 m temperature and relative humidity. A 4-day clear sky period has been chosen to study both local atmospheric circulations and their mutual interaction. Observations and simulations both show that a low-level divergence over oasis appears between 19:00 and 21:00 Beijing Time when the background mountain-plain wind system is weak. The model simulates a synergistic interaction between the oasis-desert breeze and urban-rural breeze from 16:00 until 22:00 with a maximum effect at 20:00 when the downdraft over oasis (updraft over urban) areas increases by 0.8 (0.4) Pa/s. The results show that the oasis expansion decreases the nocturnal urban heat island in the city of Urumqi by 0.8 °C, while the impact of urban expansion on the oasis cold island is negligible.
Appraisal Of Caesarean Section At The Imo State University Teaching Hospital, Orlu, Southeastern Nigeria.

Background: There is a general aversion to caesarean section among Nigerian women. However, with increasing safety of the procedure and better enlightenment, more women are beginning to accept the procedure. To maintain this increasing acceptability, Caesarean section rate as well as its attendant morbidity and mortality must be reduced to the barest minimal levels. The aim of the study is to determine the rate and the complications associated with Caesarean section at the Imo State University Teaching Hospital, Orlu.Methods: A four-year descriptive study from June 2004 to May 2008 from the Obstetrics Department of Imo State University Teaching Hospital, Orlu was conducted. All pregnant women that delivered by Caesarean section was included. The data were analyzed using simple percentages, p-value and chi-square where necessary.Results: There were 363 (33.2%) mothers who underwent Caesarean sections out of 1094 deliveries in the unit during the period under review. Postoperative complications occurred in 52 patients (14.5%). The complications cut across all reproductive age groups and parity. The commonest complications encountered were wound infection (11.5%), postpartum haemorrhage (10.1%) and anaemia (6.4%). The mortality rate was 0.8%. Conclusion: The caesarean section rate of 33.2% and complication rate of 14.5% are still high even though they are less than the figures quoted for some environments. There is still need to reduce this rate to the barest minimum for us to be able to sustain the gains of the past.
Deep, soft, and dark sounds induce autonomous sensory meridian response

There has been a growing interest in the autonomous sensory meridian response (ASMR). The ASMR is characterized by a tingling sensation around the scalp and neck and often induces a feeling of relaxation and a reduction of a negative mood. However, it is still unknown what factors affect the ASMR. The present study focused on stimulus characteristics and individuals’ mood states and personality traits. Participants filled out self-reported questionnaires (the Profile of Mood States, Beck Depression Inventory, and Big Five Inventory) and reported ASMR estimates throughout a 17-min experiment while listening to binaural tapping and brushing sounds. Cross-correlation results showed that the ASMR estimates were strongly associated with the acoustic features of auditory stimuli, such as their amplitude, spectral centroid, and spectral bandwidth. This indicates that low-pitched sounds with dark timbre trigger the ASMR. The maximum ASMR was observed around 2 s after the acoustic features changed, suggesting that the sluggishness of multisensory integration may lead to the ASMR experience. In addition, individual differences in the ASMR experience were closely linked to participants’ mood states, such as anxiety, but not to their personality traits. Our results provide important clues to understand the mechanisms of auditory-somatosensory interactions. Significant Statements The autonomous sensory meridian response (ASMR) is characterized by a tingling, electrostatic-like sensation across the scalp and back of the neck. This phenomenon can be triggered by a variety of audiovisual stimuli, and many people seek out the ASMR via the internet to receive a feeling of relaxation and reduce a negative mood. We show that the ASMR is induced about 2 s after acoustic features, such as the amplitude, spectral centroid, and spectral bandwidth are changed. This suggests that low-pitched sounds with dark timbre lead to the ASMR experience. The stimulus-driven ASMR effect is found regardless of the personality traits or mood states of participants. Our findings provide a critical clue to understand the mechanisms of auditory–somatosensory interactions.
Sports education learning program evaluation in senior high school

The Sports Education learning program evaluation has not been completely implemented. In relation to the statement, the study aims at evaluating the Sports Education learning program in Senior High School degree. Within the conduct of the study, the evaluation involved the CIPP model. Then, the informants for the study consisted of principals, vice principals, 2 Sports Education teachers and 10 students from each of Grade X, Grade XI and Grade XII. The data were gathered by means of interview, observation and documentation. For the data analysis technique, the researcher adopted the descriptive qualitative analysis. The results of the assessment in the study show that the results of context evaluation have already contained the Core Competence and the Basic Competence from 2013 Curriculum. The Components of Input have been good and the learning process of Soccer has been well-performing. Furthermore, the Components of Output show that the mean score of Core Competence 1 and Core Competence 2 belong to the “Good” category, Core Competence 3 belongs to the “Very Good” category (82.24) and Core Competence 4 belongs to the “Good” category (80.50). Therefore, it might be concluded that the Sports Education learning program in Senior High School has been well implemented. Thus, it is recommended that the Sports Education learning program should be continued with several revisions on the process.
The Linker Domain of SNAP25 Acts as a Flexible Molecular Spacer to Ensure Efficient S-Acylation

S-Acylation of the SNARE protein SNAP25 is mediated by a subset of Golgi zDHHC enzymes, in particular zDHHC17. The ankyrin repeat (ANK) domain of this enzyme interacts with a short linear motif known as the zDHHC ANK binding motif (zDABM) in SNAP25 (112-VVASQP-117), which is downstream of the S-acylated cysteine-rich domain (85-CGLCVCPC-92). In this study, we have investigated the importance of the flexible linker (amino acids 93-111; referred to as the “mini-linker” region) that separates the zDABM and S-acylated cysteines. Shortening the mini-linker had no effect of zDHHC17 interaction but blocked S-acylation. Insertion of additional flexible glycine-serine repeats had no effect on S-acylation, whereas extended and rigid alanine-proline repeats perturbed this process. Indeed, a SNAP25 mutant in which the mini-linker region was substituted with a flexible glycine-serine linker of the same length underwent efficient S-acylation. Furthermore, this mutant displayed the same intracellular localisation as wild-type SNAP25, showing that the sequence of the mini-linker is not important in this context. By using the results of previous peptide array experiments, we generated a SNAP25 mutant predicted to have a higher affinity zDABM, and this mutant showed enhanced interaction with zDHHC17 in cells. Interestingly, this mutant was S-acylated with reduced efficiency, implying that a lower affinity interaction of the SNAP25 zDABM with zDHHC17 is optimal for S-acylation efficiency. Overall, the results of this study show that amino acids 93-111 in SNAP25 act as a flexible molecular spacer to ensure efficient coupling of enzyme-substrate interaction and S-acylation.
Exploratory analysis of the effect of ruxolitinib on bone marrow morphology in patients with myelofibrosis.

7030 Background: Myelofibrosis(MF) is characterized by splenomegaly, burdensome symptoms, progressive bone marrow (BM) fibrosis, and shortened survival. Ruxolitinib (Rux), an oral, FDA-approved JAK1/JAK2 inhibitor, has demonstrated improvements in spleen volume, symptoms, and survival in patients (pts) with MF. This study was conducted to explore possible effects of long-term Rux treatment on BM morphology in MF. Methods: Trephine biopsies were obtained at baseline, 24 (67 pts), and 48 (17 pts) months (mo) from the cohort of MF patients treated at MD Anderson Cancer Center who participated in a phase I/II trial of Rux (NCT00509899). The clinical outcomes from this trial have been published previously [Verstovsek, NEJM 2010]. Two of the authors (JT and HMK) independently evaluated the World Health Organization (WHO)-defined BM fibrosis grade (0-3). Reviewers were blinded to pts characteristics and outcomes and consensus decided discordant scores. For demonstrative purposes, WHO BM fibrosis grading was also.
8-bit serialised architecture of SEED block cipher for constrained devices

This study presents an 8-bit serialised architecture of SEED block cipher for constrained devices. The circuit utilises 356 FPGA slices and 447 1-bit registers flip-flops (FFs) in the BASYS3 board, operates with an 8-bit datapath and is aimed for use on area constraints devices. In order to keep the usage of hardware resources to a minimum but, at the same time, achieve a high level of security, the key generation process of SEED is implemented through an on-the-fly procedure. In addition, the necessary S-boxes are implemented using composite field arithmetic without using any block RAMs, resulting in a very compact implementation. The proposed architecture achieves a maximum frequency equal to 125 MHz with a total latency of 280 clock cycles and a throughput up to 57.1 Mbps for encryption or decryption.
Internal Factors Affecting Continuous Donations among Cash Waqf Donors

Cash waqf has a great potential as one of Islamic innovation financial instrument to alleviate the poverty and increase socio-economic in the society. Studies into the factors contributing to the charity among public or first donation are abound. However, the factors effecting donor continuous donation or repeat donation have not yet received significant attention within the academic community. Therefore, this study aimed to identify the internal factors affecting donor’s motivation to continuous donation among cash waqf donors who are constantly contributing donation through monthly salary deduction. This article postulates that although the factors positively affecting first donation may also impact repeat donation, but the effects of these factors on the two behavioral motivations may vary. The study shows that donor continuous donation is most influenced by donor’s trust to the organizations, familiarity with the cause of organization and perceived efficacy of the contribution. These preliminary study is considered important to develop a clear understanding with regard to further improve the relationship between donors and waqf organizations in Malaysia.
PENGARUH KONSERVATISME AKUNTANSI TERHADAP MANAJEMEN LABA PADA PERUSAHAAN MANUFAKTUR DI INDONESIA

The purpose of this research is to analyze the effect of accounting conservatism to the practice of earnings management. The data used for this study is secondary data taken from the website of Indonesia Stock Exchange (IDX), specifically manufacturing companies registered in 2014-2017. Sampling for this research uses purposive sampling method, then carried out data analysis including descriptive statistics and classical assumption test. Variables used in this research are accounting conservatism as independent variable, earnings management as dependent variable, and size & ROA as control variables. Based on the result of this research, it is known that conservatism accounting and company size have significant negative effect on earnings management. Whilst ROA doesn’t have significant effect on earnings management.
Oxaliplatin-Induced Peripheral Neuropathy and Quality of Life in Patients with Digestive System Cancer

Purpose: This study aimed to identify the levels of oxaliplatin-induced peripheral neuropathy (OXLIPN) and the quality of life (QOL) related to OXLIPN in patients with digestive system cancer. Methods: A total of 83 patients with chemotherapy-induced peripheral neuropathy (CIPN)-related symptoms participated in this study. Data were collected through self-reported questionnaire which were constructed to include general and clinical characteristics, EORTC QLQ-C30, Patient Neurotoxicity Questionnaire (PNQ), and EORTC QLQ-CIPN20. Results: The average scores of OXLIPN upper and lower extremity scale were 30.01 and 29.16, respectively. The average scores of PNQ sensory and motor scale were 2.11 and 1.70, respectively. The mean score of the QLQ-C30 global health status was 54.85, and the range of mean score of the functional and symptom subdomains was 34.85~73.29 and 17.67~53.54, respectively. The CIPN-related symptoms positively correlated with the global health status scale and all subdomains of functional scale, respectively and negatively correlated with fatigue, pain, dyspnea, insomnia, and financial problem subdomains of the symptom scale, respectively. Conclusion: Oncology nurses should pay attention and provide remedies for CIPN symptoms reported by their patients. Nursing interventions should be developed for patients with digestive system cancer to alleviate CIPN and enhance their QOL.
Stochastic rounding and reduced-precision fixed-point arithmetic for solving neural ODEs

Although double-precision floating-point arithmetic currently dominates high-performance computing, there is increasing interest in smaller and simpler arithmetic types. The main reasons are potential improvements in energy efficiency and memory footprint and bandwidth. However, simply switching to lower-precision types typically results in increased numerical errors. We investigate approaches to improving the accuracy of lower-precision arithmetic types, using examples in an important domain for numerical computation in neuroscience: the solution of Ordinary Differential Equations (ODEs). The Izhikevich neuron model is used to demonstrate that rounding has an important role in producing accurate spike timings from explicit ODE solution algorithms. In particular, stochastic rounding consistently results in smaller errors compared to single-precision floatingpoint and fixed-point arithmetic with round-tonearest across a range of neuron behaviours and ODE solvers. A computationally much cheaper alternative is also investigated, inspired by the concept of dither that is a widely understood mechanism for providing resolution below the LSB in digital signal processing. These results will have implications for the solution of ODEs in other subject areas, and should also be directly relevant to the huge range of practical problems that are represented by Partial Differential Equations (PDEs).
Relationship among clinical characteristics, response and prognosis of neoadjuvant chemotherapy in patients with triple negative breast cancer

Objective To explore the clinical and pathological characteristics of triple-negative breast cancer(TNBC) and to compare the response to neoadjuvant chemotherapy and survival in patients with TNBC and non-TNBC. Methods Five hundred and thirty-five patients were included in this retrospective study. 75 patients were TNBC and 460 were non-TNBC. The clinical and pathological characteristics, 5-year disease free survival (DFS) and overall survival (OS) were analyzed. 88 patients were treated with neoadjuvant chemotherapy in which 26 patients were TNBC, the other were non-TNBC. Their responses to neoadjuvant chemotherapy, and the relations of response and survival were analyzed. Results The patients with TNBC were younger than those with non-TNBC (35 vs 44), and most of the patients with TNBC were premenopausal at diagnosis (88.0 % vs 67.2 %, P =0.009). The frequency of invasive ductal carcinoma was higher in patients with TNBC than those with non-TNBC (92.0 % vs 80.4 %, P =0.020). Generally patients with TNBC had higher grade tumors (grade Ⅱ ) than patients with non-TNBC (56.0 % vs 17.2 %, P = 0.000). Lower rate of lymph node metastasis were observed in patients with TNBC than those with non-TNBC (33.3 % vs 53.9 %, P = 0.001). Patients with TNBC had worse 5-year DFS (66.67 %) and OS (80.0 %) than those with non-TNBC (74.78 %, 90.00 %). In this study. 88 patients were treated with neoadjuvant chemotherapy. The overall response rate(OR) of patients with TNBC was 88.46 %, including 65.38 % clinical complete response (cCR)and 23.08 % clinical partial response (cPR). It was significantly higher than patients with non-TNBC respectively (82.26 %, 37.10 %, 45.16 %) (P 0.05). In contrast, TNBC patients with residual disease after neoadjuvant chemotherapy had worse 5-year DFS and OS compared with non-TNBC (P <0.05). Conclusion TNBC is common in young premenopausal women. Its main pathological style is nonspecial type of invasive ductal carcinoma with high grade, with low lymph node metastasis rate. Patients with TNBC are more sensitive to neoadjuvant chemotherapy than those with non-TNBC. Patients with TNBC have increased cCR rates compared with non-TNBC, and those with cCR have a good prognosis. TNBC patients in whom cCR are not achieved have significantly worse survival rates compared with that of non-TNBC patients. Key words: Breast neoplasms; Drug therapy, combination; Triple negative breast neoplasms; Prognosis
Virtual 3D environments as composition and performance spaces*

In the present text, I will reflect upon the composition of works that use virtual 3D environments in which the performers are represented as interacting avatars. In particular, I will explain the musical possibilities offered by this work with virtual environments, detailing the effects that the design of virtual topologies has on the interactive sound sources and sound events contained in these topologies. I will focus particularly upon how performers can musically influence said effects by navigating with the avatars acting within the topology.