Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China

Coronavirus disease 2019 (COVID‐19) is a respiratory disorder caused by the highly contagious severe acute respiratory syndrome coronavirus 2. The immunopathological characteristics of patients with COVID‐19, either systemic or local, have not been thoroughly studied. In the present study, we analysed both the changes in the number of various immune cell types as well as cytokines important for immune reactions and inflammation. Our data indicate that patients with severe COVID‐19 exhibited an overall decline of lymphocytes including CD4+ and CD8+ T cells, B cells and natural killer cells. The number of immunosuppressive regulatory T cells was moderately increased in patients with mild COVID‐19. Interleukin‐6 (IL‐6), IL‐10 and C‐reactive protein were remarkably up‐regulated in patients with severe COVID‐19. In conclusion, our study shows that the comprehensive decrease of lymphocytes, and the elevation of IL‐6, IL‐10 and C‐reactive protein are reliable indicators of severe COVID‐19.
Qualidade tecnológica, produtividade e margem de contribuição agrícola da cana-de-açúcar em função da aplicação de reguladores vegetais no início da safra

The ripening sugarcane is the most important aspect in production sistem for sugar and alcohol industry. The objective of this research was to evaluate technological quality, productivity and agricultural contribution margin of sugarcane variety RB855453 in function of plant regulators application at the beginning of the cropping season, in Igaracu do Tiete (SP), Brazil was studied. The experiment was carried out in a randomized block design with five replications. The treatments consisted of four plant regulators application of the class of growth retainers (Ethephon, Ethyl.trinexapac, Potassium nitrate and Potassium nitrate + Boron, in dosage commercial products of 2L ha-1, 0.8L ha-1, 3kg ha-1, e 3kg ha-1, respective) and a control (natural ripening). The maturators, general manner, provided the improvement technological quality of stems with positive reflex in productivity of sugar and agricultural contribution margin. The maturators Potassium nitrate + Boron, Ethephon and Ethyl-trinexapac, under weather conditions unfavourable to natural ripening process of sugarcane, allowed to anticipate the crop in five, eight, and twenty-five days, respectively, in relation a control treatment. In the subsequent crop season, under optimus weather conditions the ripening process of sugarcane, had no difference when compared to the control treatment.
Climatic variables influence the temporal dynamics of an anuran metacommunity in a nonstationary way

Abstract Understanding the temporal dynamics of communities is crucial to predict how communities respond to climate change. Several factors can promote variation in phenology among species, including tracking of seasonal resources, adaptive responses to other species, demographic stochasticity, and physiological constraints. The activities of ectothermic vertebrates are sensitive to climatic variations due to the effect of temperature and humidity on species physiology. However, most studies on temporal dynamics have analyzed multi‐year data and do not have resolution to discriminate within‐year patterns that can determine community assembly cycles. Here, we tested the temporal stability and synchrony of calling activity and also how climatic variables influence anuran species composition throughout the year in a metacommunity in the Atlantic Forest of southern Brazil. Using a multivariate method, we described how the relationship between species composition and climatic variables changes through time. The metacommunity showed a weak synchronous spatial pattern, meaning that species responded independently to environmental variation. Interestingly, species composition exhibited a nonstationary response to climate, suggesting that climate affects species composition differently depending on the season. The species‐climate relationship was stronger during the spring, summer, and winter, mainly influenced by temperature, rainfall, and humidity. Thus, temporal community dynamics seem to be mediated by species life‐history traits, in which independent fluctuations promote community stability in temporally varying environments.
On the Enhancement of Generalized Integrator-Based Adaptive Filter Dynamic Tuning Range

Many phase-locked loop (PLL) or frequency-locked loop (FLL) use quadrature signals (directly or indirectly) as the input variables. Generalized integrator (GI) is a popular quadrature signal generator (QSG) available in the literature. GI is also widely used in various industrial applications. In addition to being a QSG, GI also works as a kind of bandpass filter. However, due to structural limitations, the dynamic tuning range is limited for the standard GI. The limitation arises from using only one gain in the direct-phase estimation dynamics, while quadrature phase estimation dynamics does not use direct feedback of the filter estimation error. Some attempts have already been made to overcome this limitation by adding direct feedback of the filter estimation error to quadrature-phase dynamics as well. However, we have demonstrated in this article that this kind of implementation has some frequency domain limitations. In this article, we propose a novel GI-type adaptive filter using coordinate transformation. The resulting structure maintains the same kind of filtering property of the standard GI at the transformed coordinates level while at the same time enhancing the dynamic tuning range of standard GI. Details of the proposed technique, stability analysis, and discussion on gain tuning are provided in this article. Finally, comparative experimental results are provided with respect to GI-FLL to show the dynamic performance improvement. Experimental results demonstrate the suitability of the proposed technique.
Estimated economic impacts of seven invasive alien species in Chile

ABSTRACT This findings abstract presents preliminary estimates of the economic impact of seven invasive alien species (IAS) in Chile on productive sectors of the economy and biodiversity. The study was required by decision-makers as part of the research of the project “Strengthening National Frameworks for Invasive Alien Species Governance” funded by GEF (Global Environmental Facility). The impacts of beaver (Castor canadensis), rabbit (Oryctolagus cuniculus), wild boar (Sus scrofa), American mink (Neovison vison), yellow jacket (Vespula germanica), blackberry (Rubus spp.), and ulex (Ulex europaeus) were assessed. Few impacts could be estimated given the lack of information in Chile. Considering the impacts assessed, Chile may lose at least USD 90 million per year due to these seven IAS. Without implementing control measures, in 20 years, Chile will lose at least approximately USD 2 billion from the impacts of these species on biodiversity and productive sectors.
Investigating Feature Selection and Random Forests for Inter-Patient Heartbeat Classification

Finding an optimal combination of features and classifier is still an open problem in the development of automatic heartbeat classification systems, especially when applications that involve resource-constrained devices are considered. In this paper, a novel study of the selection of informative features and the use of a random forest classifier while following the recommendations of the Association for the Advancement of Medical Instrumentation (AAMI) and an inter-patient division of datasets is presented. Features were selected using a filter method based on the mutual information ranking criterion on the training set. Results showed that normalized beat-to-beat (R–R) intervals and features relative to the width of the ventricular depolarization waves (QRS complex) are the most discriminative among those considered. The best results achieved on the MIT-BIH Arrhythmia Database were an overall accuracy of 96.14% and F1-scores of 97.97%, 73.06%, and 90.85% in the classification of normal beats, supraventricular ectopic beats, and ventricular ectopic beats, respectively. In comparison with other state-of-the-art approaches tested under similar constraints, this work represents one of the highest performances reported to date while relying on a very small feature vector.
Human Polymorphic Genes: World Distribution

This extensive compilation of statistical data on human gene frequencies includes entries for blood groups, proteins, enzymes, HLA systems, immunoglobins, and restriction-site polymorphisms, as well as maps of gene frequency distributions. The authors are noted experts in the field, and their book will be a valuable reference for geneticists, human biologists, and physical anthropologists studying human genetic relationships and the evolution of human populations. Geneticists, human biologists, and physical anthropologists.
4-Hexylresorcinol Exhibits Different Characteristics to Estrogen

4-Hexylresorcinol (4HR) has been used as a food additive and antiseptic. The aim of this study was to evaluate whether the application of 4HR in breast cancer cells and ovariectomized rats showed estrogen-like effects. MCF-7 and SK-BR-3 cells were treated by solvent, 1–100 µM bisphenol-A (BPA), or 1–100 µM 4HR, respectively. 3-(4, 5-Dimethylthiazole-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) assay and Western blot for extracellular signal-regulated kinase-1/-2 (ERK1/2), phosphorylated ERK1/2 (p-ERK1/2), estrogen receptor-α (ERα), and ERβ were done. As an in vivo study, ovariectomized rats (n = 15) received solvent, 125 mg/kg of 4HR, or 10 µg of 17-β estradiol via daily subcutaneous injection for 7 days. Blood samples were obtained for evaluation of prolactin levels. Pituitary glands and uteruses were biopsied for histological evaluation and Western blot analysis. Compared with the control group, the application of 4HR decreased the proliferation of MCF-7 and SK-BR-3 cells, while the application of BPA increased (p < 0.05). The application of BPA increased the expression of ERα, ERβ, and p-ERK1/2, but 4HR did not change the expression of ERα, ERβ, or p-ERK1/2 in MCF-7 cells. In an animal model, the 4HR group showed similar levels of ERα, ERβ, and prolactin expression in the pituitary gland compared to the solvent only group, while the estradiol group showed higher levels. Serum prolactin levels were similar between the 4HR and solvent only groups. Taken together, 1–100 µM 4HR did not show BPA-like behavior in MCF-7 cells, and 125 mg/kg of 4HR daily subcutaneous injection for 7 days did not demonstrate estradiol-like effects in ovariectomized rats. Collectively, 4HR has no estrogen-like effects on both ERα-positive cells and estrogen-deficient rat models.
Considering Cultural Consonance in Trustworthiness of Online Hotel Reviews among Generation Y for Sustainable Tourism: An Extended TAM Model

This study aims to predict Generation Y customers’ acceptance of user-generated content (UGC) websites by integrating an extended technology acceptance model (TAM), trustworthiness of online reviews, and cultural consensus and cultural consonance theory. To collect data, a free listing method was first used to recognize our ad hoc domain, i.e., the factors that determine the trustworthiness of online hotel reviews among Generation Y in South Korea, from an emic perspective. Based on the free listing results from 39 individuals, an online survey was conducted with 273 samples using a self-administered questionnaire. Cultural consensus analysis was conducted to determine whether there is a shared cultural model in trustworthiness factors among participants, and cultural consonance values were calculated. Then, a structural equation modeling technique was used to estimate how the proposed model explains the collected data. Results indicate that an agreed-upon cultural model of trustworthiness of online hotel reviews exists among sample members. Cultural consonance of trustworthiness was found to constitute a significant antecedent of perceived ease of use and attitude towards websites in the extended TAM model. This study can contribute to predict Generation Y customers’ acceptance of UGC websites and offer meaningful implications for sustainable tourism management, particularly when cultural variables are considered.
The Impact of Implementing a 25-Year Reversion/Termination Right in Canada

Canada is actively considering legislation to limit the enforceable length of copyright transfers. Under current proposals, authors would either automatically get back their copyrights twenty-five years after a transfer or would have the opportunity to exercise an American-style termination right at year 25. This paper reports previously unpublished data from UK and Canadian book markets on the negative effect of term length on the in-print status of titles and also presents new data on the market effect of existing reversion rules deriving from the 1911 Imperial Copyright Act. Data on Canadian musicians who have used the US termination right to regain their US copyrights is also presented. The report concludes that some portion of consumer welfare losses caused by term extension in Canada may be offset by the adoption of a termination right. Although the report was prepared at the request of Canadian Heritage, a branch of the Canadian government, it represents only the views of the author.
Strategic factors and significance of organizational innovation and organizational learning in organizational performance

PurposeThe study investigates the experience and significance of strategic factors in organizational innovation (OI) and organizational learning (OL). The study also examines the impact of OI and OL on organizational performance.Design/methodology/approachThe study takes a quantitative approach, with cross-sectional data collected to achieve its purpose. The respondents are CEOs of different organizations. The data collection tool, a survey questionnaire, is applied to a random sample. In total, data from 360 usable cases are analyzed to infer the results.FindingsAfter employing structural equation modeling (SEM), the study findings reveal the positive and significant impact of strategic factors on OI and OL, with these factors comprising personal mastery, transformational leadership, a shared vision, proactivity, and the environment. Furthermore, OI and OL have a positive and significant impact on organizational performance.Practical implicationsThe study's findings may reinforce knowledge of the different strategic factors/capabilities needed to attain a satisfactory level of organizational capabilities and, consequently, may increase organizational performance and encourage entrepreneurship. An investigation of these factors may impart benefits to an organization, such as becoming more innovative or providing a boost to learning. Managers of organizations may generate circumstances to make it easier to achieve the growth of these strategic factors/capabilities.Originality/valueThe study's findings may help to develop a better understanding of strategic factors, OI, OL, and organizational performance, particularly in a developing country context.
Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients

Protein phosphorylation is a posttranslational modification that is essential for normal cellular processes; however, abnormal phosphorylation is one of the prime causes for alteration of many structural, functional, and regulatory proteins in disease conditions. In cancer, changes in the states of protein phosphorylation in tyrosine residues have been more studied than phosphorylation in threonine or serine residues, which also undergo alterations with greater predominance. In general, serine phosphorylation leads to the formation of multimolecular signaling complexes that regulate diverse biological processes, but in pathological conditions such as tumorigenesis, anomalous phosphorylation may result in the deregulation of some signaling pathways. Cervical cancer (CC), the main neoplasm associated with human papillomavirus (HPV) infection, is the fourth most frequent cancer worldwide. Persistent infection of the cervix with high-risk human papillomaviruses produces precancerous lesions starting with low-grade squamous intraepithelial lesions (LSIL), progressing to high-grade squamous intraepithelial lesions (HSIL) until CC is generated. Here, we compared the proteomic profile of phosphorylated proteins in serine residues from healthy, LSIL, HSIL, and CC samples. Our data show an increase in the number of phosphorylated proteins in serine residues as the grade of injury rises. These results provide a support for future studies focused on phosphorylated proteins and their possible correlation with the progression of cervical lesions.
The egg characteristics of malon broiler, Japanese quails and their cross

Abstract. Sujana E, Anang A, Setiawan I, Widjastuti. 2020. The egg characteristics of malon broiler, Japanese quails and their cross. Biodiversitas 21: 889-895. Research on evaluation of the characteristics of Malon broiler and Japanese quails (Coturnix coturnix japonica) eggs and on the crossbreeding between the two has been implemented in the Quail Breeding Center, Universitas Padjadjaran, Jatinangor, Indonesia. The purpose of this research is to know and evaluate the characteristics of Malon broiler and Japanese quails eggs and the crossbreeding between the two. The research used experimental method with complete random draft consisting of 4 treatments with six repeats, with each replay unit consisting of 10 grains so that the total of incubator eggs used are 240 grains. The treatment used was the breeding or marriage of Malon broiler quail ♂ x Malon broiler quail ♀ (MM), selected Japanese quail ♂ x selected Japanese quail ♀ (JJ), Malon broiler quail ♂ x selected Japanese quail ♀ (MJ), and Japanese selected quail ♂ x Malon broiler quail ♀ (JM). Statistical analysis was conducted using GLM (General Linear Model) with test Duncan using SAS application programs. The observed parts are egg weight, egg shape or Shape Index (SI), specific gravity (SG), and eggshell thickness. The results showed a noticeable difference in those parts. Further research results showed that the best quality of egg incubator comes from the crossbreeding of Malon broiler quail ♂ x selected Japanese quail ♀(MJ), which is good for breeding quails.
Estimating Viability of Gopher Tortoise Populations

Abstract : Although the gopher tortoise (Gopherus polyphemus) is widespread across the southeastern United States where conditions are favorable, the species is in serious decline. While biologists and land managers might consider any of a variety of in-situ and ex-situ management options when determining how best to manage individual populations, there are no good decision tools for evaluating or predicting whether the existing population is viable in the long term. This study developed demographic models for gopher tortoise populations and has proposed to use those models to predict outcomes for a variety of population conditions and management scenarios. The major limiting factor in the development of models was the availability of complete lifehistory data. Because of its demonstrated importance in population stability in other turtle species, adult survivorship was assumed to be high in all model scenarios. However, reproduction and survivorship of other life stages varied among simulations. The model results demonstrated that, of the parameters manipulated, hatchling survivorship was the most critical life history stage because of the very small likelihood that hatchlings survive to their second year. Any management actions that increase hatchling success are likely to increase population viability significantly.
Minimal Weak Truth Table Degrees and
 Computably Enumerable Turing Degrees

Two of the central concepts for the study of degree structures in computability theory are computably enumerable degrees and minimal degrees. For strong notions of reducibility, such as m-deducibility or truth table reducibility, it is possible for computably enumerable degrees to be minimal. For weaker notions of reducibility, such as weak truth table reducibility or Turing reducibility, it is not possible to combine these properties in a single degree. We consider how minimal weak truth table degrees interact with computably enumerable Turing degrees and obtain three main results. First, there are sets with minimal weak truth table degree which bound noncomputable computably enumerable sets under Turing reducibility. Second, no set with computable enumerable Turing degree can have minimal weak truth table degree. Third, no ∆2 set which Turing bounds a promptly simple set can have minimal weak truth table degree. Received by the editor October 6, 2016. 2010 Mathematics Subject Classification. Primary 03D25; Secondary 03D28, 03D30.
Is Foreign Exchange Intervention a Panacea in Diversified Circumstances? The Perspectives of Asymmetric Effects

Owing to the country’s heavy reliance on exports, the role of foreign exchange intervention in South Korea’s economic development is self-evident. The effectiveness of the intervention is what we are concerned with in this paper. Recently, a growing body of literature has engaged in exploring the asymmetric effects of foreign exchange intervention both theoretically and empirically. Against this background, we employ a threshold vector autoregression (TVAR) model in parallel with its generalized impulse response functions (GIRFs) to show that there are asymmetric effects of the Bank of Korea (BOK)-led interventions regardless of the volatility regimes.
Developing a Modified Umbrella Index for Conservation of Macroinvertebrate Diversity in Taizi River Basin, China

Conservation strategies for a reliable set of umbrella species should benefit many co-occurring species and will improve conservation efficiency. The umbrella index (UI) is increasingly applied for umbrella species selection in different ecosystems. We developed a modified river UI to select potential macroinvertebrate umbrella species with a combination of 69 sites in the Taizi River Basin of northeast China. Calculation of UI and comparison of biotic indices between sites of presence and absence of umbrella species were performed to make the final umbrella species list. The umbrella scheme, based on the proportion and composition of sites supporting the confirmed umbrella species, was introduced to illustrate the conservation effectiveness. A total of eight umbrella species were obtained and all of them were aquatic insects, such as caddisfly and mayfly larva. Umbrella schemes supporting the top umbrella species, hosted the majority of co-occurring species and only 7% of beneficiary species were missed by the umbrella schemes of 70% effort. The positive relationship between abundance of co-occurring species and umbrella species, validated the ability of umbrella species to confer protection and co-existence of co-occurring species, and thus indicated the effectiveness of umbrella species conservation. Co-occurring species were located close to umbrella species in ordinations, suggesting they respond to similar environmental variables characterized by high flow velocity, dissolved oxygen and pebble-covered substrate. On account of good performance of umbrella schemes in our study, UI with further improving methods should be promoted for selection of umbrella species and decision for optimizing of conservation sites in the future.