Miracle-dz/UniFAR-FTUs huggingface dataset:
Microbial succession and its correlation with the dynamics of flavor compounds involved in the fermentation of Longxi bacon

Introduction Longxi bacon is a traditional fermented meat from Gansu province, China. The ripening process of the bacon is crucial for quality and flavor. The aim of this study was to gain deeper knowledges on the bacterial and fungal community diversity and the changes of chemical components including fatty acids and volatile compounds at different time points during the ripening of the bacon and to understand the relationship between microbial profiles and the chemical components related the bacon flavor. Methods Bacon samples were collected from days 0, 15, 30, 60 and 90. The bacterial and fungal compositions were analyzed with next generation sequencing targeting the 16S rDNA loci for bacteria and ITS loci for fungi. The fatty acids and the volatile components were analyzed by headspace solid phase micro extraction followed by gas chromatography/mass spectrometry (HS-SPME-GC/MS). Results We found that the abundance of bacteria in bacon was higher than that of fungi, and Psychrobacter, Brochothrix, Phoma and Trichoderma was the dominant bacon’s population. The largest contributors of volatiles were aldehydes, ketones and esters, and the main fatty acids were palmitic, oleic and linoleic acids. Pearson correlation analysis between microbial succession and key flavor substances showed that the production of Longxi bacon flavor is the result of a combination of bacteria and fungi. Ten bacteria genera and six fungi genera were determined as functional core microbiota for the flavor production based their dominance and functionality in microbial community. In addition, bacteria and fungi are involved in the oxidation and hydrolysis of fatty acids during the ripening of bacon, which also contributes to the formation of bacon flavor. Discussion This study provides a comprehensive analysis of the key microbiota involved in shaping bacon’s distinctive flavor. Here, the results presented should provide insight into the influence of the microenvironment on the microbial community in bacon and lay a foundation for further investigations into the food ecology of bacon.
Relaxing Retinotomy in Recurrent and Refractory Full-Thickness Macular Holes: The State of the Art

The prevailing standard of care for primary repair of full-thickness macular holes (FTMHs) is pars plana vitrectomy with internal limiting membrane (ILM) peeling and gas tamponade, as it gives a high closure rate of roughly 90%. On the other hand, the surgical management of recurrent and refractory FTMHs represents, so far, a demanding and debated subject in vitreoretinal surgery since various approaches have been proposed, with no consensus concerning both adequate selection criteria and the best surgical approach. In addition, the existence of multiple case series/interventional studies showing comparable results and the lack of studies with a direct comparison of multiple surgical techniques may lead to uncertainty. We present an organized overview of relaxing retinotomy technique, a surgical approach available nowadays for the secondary repair of recurrent and refractory FTMHs. Besides the history and the description of the various techniques to perform relaxing retinotomies, we underline the results and the evidence available to promote the use of this surgical approach.
Investigating Crustal Deformation Associated With The North America-Pacific Plate Boundary In Southern California With GPS Geodesy

9 INTRODUCTION . 11 SUMMARY OF WORK . 20 REFERENCES . 27 APPENDIX A: PRESENT-DAY STRAIN ACCUMULATION AND SLIP RATES ASSOCIATED WITH SOUTHERN SAN ANDREAS AND EASTERN CALIFORNIA SHEAR ZONE FAULTS . 37 Abstract . 38
Quality of life in adolescents. A longitudinal study of the impact of the COVID-19 pandemic

Several studies have reported that health-related quality of life (HRQoL) in adolescents has decreased during the COVID-19 pandemic. In this study, HRQoL was analyzed in young people aged 13 to 17 years after the end of the pandemic. For this purpose, we followed up at three different points in time: before the pandemic (2019), during (2021) and after the pandemic restrictions (2022). A time-lag design in three phases was used, with a total of 2027 adolescents completing the Kidscreen-10 HRQoL questionnaire. ANOVA and logistic regression models were used to analyze the influence of gender, playing sports and mental health treatment. The results obtained showed a worsening of HRQoL in 2021, when young people returned to school on a blended learning basis. This worsening occurred regardless of gender. In 2022, once all restrictions were removed, boys recovered health-related quality of life to pre-pandemic levels, but this did not occur in girls. The same happened with young people in mental health treatment. In all cases, doing sports was shown to be a protective factor for HRQoL Diversos estudios han informado que la calidad de vida relacionada con la salud (CVRS) en adolescentes ha disminuido durante la pandemia por COVID-19. En este trabajo se analizó la CVRS en jóvenes de 13 a 17 años una vez finalizada la pandemia. Para ello se hizo un seguimiento en tres momentos diferentes: antes de la pandemia (2019), durante las restricciones de la pandemia (2021) y tras las restricciones de la misma (2022). Se utilizó un diseño de retardo temporal (time-lag design) en tres fases, con un total de 2027 adolescentes que cumplimentaron el cuestionario Kidscreen-10 de CVRS. Mediante modelos ANOVA y de regresión logística se analizó la influencia del género, la práctica deportiva y estar en tratamiento en salud mental. Los resultados obtenidos mostraron un empeoramiento de la CVRS en 2021, cuando los jóvenes volvían a los centros educativos en régimen de semipresencialidad. Este descenso fue independiente del género. En 2022, una vez eliminadas todas las restricciones, la CVRS se recuperó a niveles prepandemia en los chicos, pero no en las chicas. Lo mismo ocurrió con los jóvenes en tratamiento de salud mental. En todos los casos, la práctica deportiva se mostró como un factor protector de la CVRS.
Enhancing Anti-SARS-CoV-2 Neutralizing Immunity by Genetic Delivery of Enveloped Virus-like Particles Displaying SARS-CoV-2 Spikes

New vaccine delivery technologies, such as mRNA, have played a critical role in the rapid and efficient control of SARS-CoV-2, helping to end the COVID-19 pandemic. Enveloped virus-like particles (eVLPs) are often more immunogenic than protein subunit immunogens and could be an effective vaccine platform. Here, we investigated whether the genetic delivery of eVLPs could achieve strong immune responses in mice as previously reported with the immunization of in vitro purified eVLPs. We utilized Newcastle disease virus-like particles (NDVLPs) to display SARS-CoV-2 prefusion-stabilized spikes from the WA-1 or Beta variant (S-2P or S-2Pᵦ, respectively) and evaluated neutralizing murine immune responses achieved by a single-gene-transcript DNA construct for the WA-1 or Beta variant (which we named S-2P-NDVLP-1T and S-2Pᵦ-NDVLP-1T, respectively), by multiple-gene-transcript DNA constructs for the Beta variant (S-2Pᵦ-NDVLP-3T), and by a protein subunit–DNA construct for the WA-1 or Beta variant (S-2P-TM or S-2Pᵦ-TM, respectively). The genetic delivery of S-2P-NDVLP-1T or S-2Pᵦ-NDVLP-1T yielded modest neutralizing responses after a single immunization and high neutralizing responses after a second immunization, comparable to previously reported results in mice immunized with in vitro purified S-2P-NDVLPs. Notably, genetic delivery of S-2Pᵦ-NDVLP-3T yielded significantly higher neutralizing responses in mice after a second immunization than S-2Pᵦ-NDVLP-1T or S-2Pᵦ-TM. Genetic delivery also elicited high spike-specific T-cell responses. Collectively, these results indicate that genetic delivery can provide an effective means to immunize eVLPs and that a multiple-gene transcript eVLP platform may be especially efficacious and inform the design of improved vaccines.
Hypersonic FLEET velocimetry and uncertainty characterization in a tripped boundary layer

Femtosecond laser electronic excitation tagging (FLEET) velocimetry is applied in a hypersonic boundary layer behind an array of turbulence-inducing trips. One-dimensional mean velocity and root-mean-square (RMS) of velocity fluctuation profiles are extracted from FLEET emissions oriented across a 2.75∘ wedge and through a boundary layer above a flat plate in two test campaigns spanning 21 tunnel runs. The experiment was performed in the Texas A&M University Actively Controlled Expansion tunnel that operated near Mach 6.0 with a Reynolds number near 6 × 106 m−1 and a working fluid of air at a density near 2.5 × 10−2 kg m−3. Detailed analysis of random and systematic errors was performed using synthetic curves for error in the mean velocity due to emission decay and the error in the RMS velocity fluctuation due to random error. The boundary layer behind an array of turbulence-inducing trips is documented to show the breakdown of coherent structures. FLEET velocimetry is compared to the tunnel Data Acquisition System, Vibrationally Excited Nitric Oxide Monitoring results, and Reynolds-Averaged Navier–Stokes computational fluid dynamics to verify results.
Pedestrian malls, streetscapes, and urban spaces

Evolution of Urban Spaces and Pedestrian Malls. Pedestrian Mall Development. Feasibility Analysis. Context and Form Characteristics. Design Elements and Street Furniture. Plants in the City. Pedestrian Mall Case Studies. Comparative Analysis of Pedestrian Malls. Urban Spaces. Bibliography. Index.
Linked Fate and Social Identity: Black and White Women’s Attitudes About Abortion and MeToo

The recent social and political inequalities women face in the United States have raised new questions about how distinct groups of women respond to a changing landscape. Here, we assess how racial and political differences shape women’s social identity as women and its association with support for abortion and the MeToo movement. Using original survey data, we find that for both Black and white women, gender-linked fate—the belief that one’s fate is tied to the well-being of the gender group—is predicted by political ideology and associated with attitudes about abortion and the MeToo movement. In contrast, social identity as a woman—when one feels deeply tied to and represented in a particular gender group—was common across the political spectrum and insignificant in predicting attitudes about these gendered political issues.
Response of the tomato rhizosphere bacterial community to water–oxygen coupling under micronanobubble oxygenated drip irrigation in mildly saline soil

The deterioration of the soil water–air environment due to salinization can reduce soil bacterial activity and cause crop yield reduction. Micronanobubble oxygenated drip irrigation can significantly improve the nonsaline soil water–air environment and enhance bacterial activity, but its effect on salinized soil bacteria is unknown. In this study, we used a tomato cultivation experiment in mildly saline soil to evaluate the responses of the rhizosphere bacterial community to the soil microenvironment created by micronanobubble oxygenated drip irrigation. The results indicated that the soil environmental factors (including soil electrical conductivity, i.e., EC) (r = 0.46) and root length (r = −0.86) had important regulatory effects on bacterial community function, which had significant direct effects on tomato yield (r = 0.46). The moderate dissolved oxygen concentration treatment significantly reduced the EC by 63.22%–73.32% compared with CK (noncultivated soil treatment) and generally increased the root length; however, only the combination of a moderate dissolved oxygen concentration and excess irrigation (A15W1.2) significantly increased tomato yields by 190.90% compared with A0W0.8 (the combination of a low dissolved oxygen concentration and insufficient irrigation) because the irrigation water volume was the limiting condition affecting the benefits of the root length increase. The high dissolved oxygen concentration treatment significantly reduced the EC by 60.36%–92.31% and increased the bacterial community diversity by 4.08%–6.16% compared with CK; these aforementioned changes favored the increase in tomato yield. However, similar to the result of the moderate dissolved oxygen treatments, the tomato yields were significantly higher and among the highest of all treatments only when a high dissolved oxygen concentration was combined with sufficient irrigation or excess irrigation (A30W1 or A30W1.2) due to the limiting effect of the irrigation water volume. Therefore, accounting for the changes in EC, soil bacterial community, and tomato yields, A15W1.2, A30W1, and A30W1.2 are recommended for tomato production in mildly saline soils.
Autologous, allogeneic hematopoietic cell transplantation and CAR-T/NK therapy: what is their real importance in PTCL?

Peripheral T cell lymphoma (PTCL) is a rare and aggressive type of non-Hodgkin’s lymphoma that affects mature T cells. This type of cancer is characterized by the abnormal growth of T cells, which can accumulate in the lymph nodes, spleen, bone marrow, and other organs, leading to a variety of symptoms. PTCLs are often difficult to diagnose and treat, and they have a poorer prognosis than other types of lymphoma. However, recent advancements in treatment options, such as targeted therapies have shown promise in improving outcomes for patients with PTCL. Here, we discuss the use of autologous and allogeneic hematopoietic cell transplantation (HCT) as a treatment strategy for patients with PTCL, as well as the recent treatment approaches based on advanced cellular therapy. The current evidence for the use of HCT in PTCL is mainly derived from registry data, retrospective studies, and expert opinion, as randomized trials are limited due to the low incidence and histological heterogeneity of PTCL subtypes.
Myocardial Work in Middle-Aged Adults with Overweight and Obesity: Associations with Sex and Central Arterial Stiffness

We explored global myocardial work index (GWI), a novel measure of myocardial function that integrates left ventricular (LV) hemodynamic load, in relation to sex and increased body mass index (BMI). We used data from 467 individuals (61% women, average age 47 ± 9 years and BMI 31.2 kg/m2) without known cardiac disease. Central arterial function was analysed by applanation tonometry. GWI was calculated from global longitudinal strain (GLS) and post-echocardiography supine blood pressure (BP). Covariables of GWI were identified in linear regression analyses. Women had higher BMI, aortic augmentation pressure (12 ± 7 vs. 8 ± 6 mmHg), LV GLS (20.0 ± 2.8 vs. 18.8 ± 2.8%), and GWI (2126 ± 385 vs. 2047 ± 389 mmHg%) than men (all p < 0.05). In univariable analyses, higher GWI was associated with female sex, higher age, systolic BP, LV wall stress, LV ejection fraction, left atrial size, LV ejection time, and with lower waist circumference (all p < 0.05). In multivariable analysis, adjusting for these correlates, female sex remained independently associated with higher GWI (β = 0.13, p = 0.007). After additional adjustment for aortic augmentation pressure or central pulse pressure, this association became non-significant. In conclusion, the higher GWI in women compared to men was mainly explained by increased LV workload due to higher aortic augmentation pressure in women.
Isotropic One-Way Times of Flight of Laser Pulses and Einstein's "compressible fluid" Space

We present measurements of one-way times of flight of 25 fsec laser pulses, along a given distance, in different directions in space. Using autocorrelation, a technique that dispels the need for clocks and their synchronization, we obtained full isotropy. Einstein showed [1] that stars confine their local spaces and concluded that space is a "compressible fluid". Any static instrument on Earth is thus stationary relative to its local space and should yield isotropic results, as we have obtained. Our results validate the second postulate of Special Relativity [2] and support Einstein's idea.
Production and Characterization of Novel Fabs Generated from Different Phage Display Libraries as Probes for Immunoassays for Gluten Detection in Food

Gluten is the main fraction of wheat proteins. It is widely used in the food industry because of the properties that are generated in the dough, but it is also able to trigger diseases like allergies, autoimmunity processes (such as celiac disease), and intolerances in sensitized persons. The most effective therapy for these diseases is the total avoidance of gluten in the diet because it not only prevents damage but also enhances tissue healing. To ensure the absence of gluten in food products labeled as gluten-free, accurate detection systems, like immunoassays, are required. In this work, four recombinant Fab antibody fragments, selected by phage display technology, were produced and tested for specificity and accuracy against gluten in experimental flour mixtures and commercial food products. A high-affinity probe (Fab-C) was identified and characterized. An indirect ELISA test was developed based on Fab-C that complied with the legal detection limits and could be applied in the assessment of gluten-free diets.
Getting biodiversity projects to work : towards more effective conservation and development

Section I. The challenge of linking conservation and development1. Trying to better understand integrated conservation and development, by Thomas O. McShane and Michael P. Wells2. Jack of all trades, by master of none: inherent contradictions among ICD approaches, John G. Robinson a3. The pathology of projects, by Jeffery Sayer and Michael P. Wells4. Expecting the unattainable: the assumptions behind ICDPs, by Thomas O. McShane and Suad A. NewbySection II. Application and Issues5. Fitting ICD into a project framework: the CARE experience, by Phil Franks and Thomas Blomley6. Making biodiversity conservation a land-use priority, by Agnes Kiss7. Yellowstone: a 130-year experiment in integrated conservation and development, by Dennis Glick and Curtis Freese8. Policies, by parks and projects: a review of three Costa Rican ICDPs, Katrina Brandon and Mic9. Indigenous peoples and protected areas: the case of the Sibuyan Mangyan Tagabukid, by Philippines, Edgardo Tongson and Marisel Dino10. Land tenure and state property: a comparison of the Korup and Kilum ICDPs in Cameroon, by Steve Gartlan11. Trade-off analysis for integrated conservation and development, by Katrina Brown12. Transforming approaches to CBNRM: learning from the Luangwa experience in Zambia, by Brian Child and Barry Dalal-Clayton13. Ecodevelopment in India, by Shekhar Singh and Arpan Sharma14. Conservation landscapes: whose landscapes, by whose trade-offs? , Stewart Maginnis, Bill Jackson and Nigel Dudley15. Poverty and forests: sustaining livelihoods in integrated conservation and development, by Gill ShepherdSection III. Conclusions16. Using adaptive management to improve ICDPs, by Nick Salafsky and Richard Margoluis17. The future of integrated conversation and development projects: building on what works, by Michael P. Wells, Thomas O. McShane, Holly T. Dublin, Sheila O'Connor and Kent
Measurements of Internal Waves in the Strait of Gibraltar Using a Shore-Based Radar.

Abstract : During the period 22-24 October 1983, a feasibility study was made on the use of standard shore radars to monitor the temporal and spatial distribution of internal waves. A radar (150 m elevation) situated at Gibraltar was used to monitor the surface manifestations of internal waves in the Strait of Gibraltar during three semidiurnal tidal periods. The eastward progression of internal waves within an arc approximately 19 km from the radar was observed. These observations fill a gap in the evolution of the surface signatures of internal waves between the small-scale view of ship radars and the large-scale view afforded by satellites and the Space Shuttle. (Author)
PLANTAS MEDICINALES USADAS EN ALGUNAS VEREDAS DE MUNICIPIOS DEL ALTIPLANO DEL ORIENTE ANTIOQUEÑO, COLOMBIA

Durante once anos se han recolectado cuerpos fructiferos de los macromicetes de la ciudad universitaria de la Universidad de Antioquia (Medellin), Colombia. Se realizaron 42 colecciones que corresponden a 28 especies, 26 distribuidas en 22 generos, 10 familias y 3 ordenes de la division Basidiomycota, las especies restantes pertenecen al genero Xylaria , (Xylariaceae, Xylariales) division Ascomycota. Se registran, por primera vez, ocho especies para Colombia y seis para el departamento de Antioquia. Para cada una de las especies se incluyen datos sobre su distribucion. Palabras clave: ambientes urbanos, Ascomycota, Basidiomycota, diversidad de macromicetes, nuevos registros
Comparison of the Efficiencies of the Prognostic Generalized Complementary Functions on Evaporation Estimation

Several prognostic generalized complementary functions have been proposed to estimate evaporation in recent years. However, there are few comparative studies about the performance of these predictable complementary functions at the global scale. This study compared the efficiencies of four prognostic generalized complementary functions on evaporation estimation at 195 eddy covariance (EC) sites. The four complementary functions include the polynomial function proposed by Brutsaert (2015, B2015, https://doi.org/10.1002/2015wr017720), the rescaling functions proposed by Crago et al. (2016, C2016, https://doi.org/10.1002/2016WR019753) and by Szilagyi et al. (2017, S2017, https://doi.org/10.1002/2016JD025611), and the sigmoid function proposed by Han and Tian (2018, H2018, https://doi.org/10.1029/2017wr021755). The results show that the four prognostic generalized complementary functions can provide an acceptable estimation of E (Pearson correlation coefficient ≈ 0.8; root‐mean‐square error <30 W m−2) in most of the global EC sites. For different ecosystem types, C2016 performs better in forests, shrublands, and grasslands, and H2018 performs better in wetlands and croplands. Each function has specific advantages. B2015 is popular because of its concise functional form; C2016 and S2017 are fully calibration‐free algorithms and have rescaling processes for each observation, and C2016 performs best on the monthly E estimation; H2018 suits for site mean estimation and has the most stable performance among all ecosystem types. However, all the functions have limitations, and there is still room for improvement. This study provided evidence for previous theoretical studies about the rationality of the complementary functions from the view of numerical simulation, and can help the wide application of the complementary functions on regional and global E estimation.