Miracle-dz/UniFAR-FTUs huggingface dataset:
Global, Regional, and National Burden and Trends of Down Syndrome From 1990 to 2019

Introduction: Down syndrome (DS) is the leading cause of genetically defined intellectual disability and congenital birth defects worldwide. A large population of people diagnosed with DS globally is posing an enormous socioeconomic burden. However, the global burden and trends of DS have not been reported. Methods: Based on the data from the Global Burden of Disease database in 2019, we analyzed the incidence, prevalence, disability-adjusted life years (DALYs), and death of DS from 1990 to 2019 according to sex, age, regions, and social-demographic index (SDI). Then, age-standardized rates (ASRs) and estimated annual percentage change (EAPC) of these aforementioned indexes were calculated to evaluate the temporal trend of DS. Finally, the association of SDI with DS epidemiological parameters was assessed. Results: In the past 30 years, the incident cases, age-standardized incident rate (ASIR), and age-standardized prevalent rate (ASPR) of DS first decreased slightly and subsequently increased globally. The number of prevalent cases increased steadily, while the number and age-standardized rate (ASRs) of DALYs and deaths decreased gradually from 1990 to 2019. In the meantime, disease burdens were different across various SDI regions. The prevalent cases and ASPR for both sexes were increasing in all SDI regions except for the high-middle SDI region. At the national level, Brunei Darussalam, Ireland, and Haiti were the top three countries with the highest ASIR in 2019. Georgia was in the top three with the highest increase in ASRs of four parameters, while Serbia was consistently ranked in the top three with fastest declining. Furthermore, we found that ASIR and ASPR were positively correlated with SDI, yet the age-standardized DALYs and age-standardized death rate (ASDR) were negatively correlated with SDI. Conclusion: In the past 30 years, the burden and trends of DS were heterogeneous across different regions and countries with different sociodemographic characteristics. Great improvements had been achieved in reducing DALYs and deaths globally. However, the increased number and ASRs of incident and prevalent cases in some regions, especially in low SDI regions, were contributing to numerous challenges to public health. The findings may provide valuable information to the development or implementation of more effective measures.
Authentic Leadership Questionnaire applied to Brazilian nurses: evidence of validity

Abstract Objective: to establish the psychometric properties of the Authentic Leadership Questionnaire (ALQ) applied to Brazilian nurses. Method: cross-sectional observational study with a non-probabilistic sample. The psychometric properties of the RATER and SELF versions of the ALQ were calculated using confirmatory factor analysis with the WLSMV robust estimation method. The following indices were used to assess the goodness-of-fit of the model: chi-square by degrees of freedom (χ2/df), Tucker-Lewis Index (TLI), Comparative Fit Index (CFI), Root Mean Square Error of Approximation (RMSEA) and Standardized Root Mean Squared Residual (SRMR). Data reliability was analyzed using the ordinal coefficient alpha and composite reliability. Results: 181 nurses participated of the study (female gender: 80.1%; mean age of 34.6 years; working time of less than five years: 76.3%). The complete ALQ RATER and ALQ SELF models did not present an adequate fit. Therefore, the refined models presented a better fit to the sample data (ALQ RATER: χ2/df=2.77; CFI=0.97; TLI=0.97; RMSEA=0.10; SRMR=0.05; ALQ SELF: χ2/df=2.74; CFI=0.94; TLI=0.92; RMSEA=0.10; SRMR=0.08). In the ALQ RATER model, items 1, 7 and 13 were excluded. Due to the high correlation between the factors Relational Transparency and Moral Perspective, a three-factor model based on the combination of the factors mentioned above was proposed. In the ALQ SELF model, items 2, 5, 9 and 10 were excluded. Likewise, a three-factor model based on the combination of two factors, now called Self-Awareness Balance, was proposed. Conclusion: the data obtained with the Authentic Leadership Questionnaire with Brazilian nurses were valid and reliable.
‘You can’t un-see what you’ve seen’: An ex-prison officer's autoethnographic account of suicide and self-harm in a UK male adult prison

Internationally, prisons are challenging environments for officers and prisoners, and suicide and self-harm have ramifications for both parties. Suicide and self-harm in prison far exceed prevalence in the general population and officers experience many psychological and emotional impacts including distress, bereavement, guilt, shame, accountability, desensitisation and PTSD. This article explores relational and institutional dynamics and cultural expectations placed upon officers when dealing with suicide/self-harm. Prison officer culture can be limited in supporting officers around trauma and it can be perceived as stigmatising and a weakness to seek help. This article explores a former prison officer's experience of dealing with trauma around self-harm and suicide including the first experience of suicide, moral conflict and the impact of losing a colleague to suicide. I worked as a prison officer at a category ‘B’ local prison in the (UK) between 2003 and 2009 and kept a reflective journal during service. Drawing upon Autoethnography (AE), I seek to explore the lived experience of trauma from an ‘insider perspective’ using prison research to interpret retrospective accounts. Concepts around emotional labour, occupational morality and prison officer occupational culture/ socialisation are used to highlight the complexities of prison officer work around suicide/self-harm. The prison service (UK) needs to reduce stigma in officers who need help and support around mental health and coping with trauma, with strategies like peer support programmes, regular supervision/mandatory counselling and extensive debriefs to support officers in the aftermath of traumatic critical incidents.
Employee Engagement and Innovative Work Behavior Among Chinese Millennials: Mediating and Moderating Role of Work-Life Balance and Psychological Empowerment

Given the ever-changing business environment, organizations are forced to consider innovation as an essential prerequisite to enhance their efficiency, productivity, and sustainability. In this regard, organizations pay increased attention to enhancing employees' engagement (EE) and stimulating their innovative work behaviors (IWBs). Research emphasizes the importance of employees' IWBs in achieving competitive advantages and organizational sustainability. In this research, we address the question of whether employee engagement leads to stimulating IWBs of the Chinese millennial workforce in service industries. In addition, we explore the potential mediating effect of work-life balance (WLB) and the moderating influence of psychological empowerment (PE) on the relationship between EE and IWBs. Self-administered questionnaires were used to collect data from 372 Chinese senior employees working in the IT, trade, real estate, financial, and telecommunication industries. Our empirical findings showed that highly engaged employees are most likely to exhibit IWBs and maintain a WLB. In addition, the relationship between EE and IWB was partially mediated by WLB. Moreover, the interaction between EE and PE was found to strengthen employees' IWBs. Our study contributes to understanding the importance of EE as an essential prerequisite for millennials' IWBs and provides new insights for service organizations to encourage employees' IWBs. This study contributes to the human resource management field by offering valuable implications vis-à-vis how service organizations operating in a turbulent business environment stimulate the IWBs of their millennial workforce.
Culturally Relevant Frames Increase Individuals’ Motivation to Contribute to Carbon Emissions Offsets

We theorized that culturally-relevant frames—language that invokes valued cultural concepts without changing the communicated information—can increase people’s willingness to engage in environmental action. Across eight experiments (N = 10,294) in two national contexts, we adjusted the language of a carbon offset request that people received as part of a simulated flight purchase. We investigated the role of five constructs that are valued across cultures but vary in their importance: choice, economic growth, social change, moral responsibility, and sanctity. We found that the social change, moral responsibility, and sanctity frames did not differ from the control condition in either culture. Invoking the concept of economic development increased Indians’ willingness to contribute to a carbon offset compared to the control frame, whereas invoking the concept of choice increased US Americans’ willingness. If these simulated decisions translate into actual actions, the findings suggest that framing environmental requests using culturally-relevant frames have the potential to promote sustainable behavior. More generally, the findings highlight the importance of paying attention to culture to motivate environmental action.
Coping Strategy of Family in Treating Children with Thalassemia Mayor aged 6–12 Years in the Urban Area of Indonesia

BACKGROUND: Thalassemia is a genetic blood disorder and has not been cured. Thalassemia children need special attention from the family as one of the efforts in treating children with thalassemia depends on coping strategies owned by the family. AIM: This research aimed to discover and deeply explore coping family strategies in caring for children with thalassemia major aged 6–12 years. METHODS: This study used quantitative and qualitative approaches (mixed methods). For quantitative study we used total sampling technique(66 samples). furthermore, for qualitative study, we used six participants with in depth-interview technique. The instrument was used the revised ways of coping scale questionnaire and interview guidelines. RESULTS: The study showed that 62. 2% of respondents had a positive coping strategy, and (37.8%) had a negative coping mechanism. Furthermore, the qualitative analysis showed that age, education, employment status, and the number of childreninfluenced individual coping strategies. The interview results show three themes, namely the process of grieving, fear of stigma, and an increase in spiritual activity. It is recommended for families to follow health education on caring for children with thalassemia.
Why Do Chinese Employees Complain at the Workplace? An Exploratory Study Based on the Theory of Work Adjustment

This study aims to investigate the causes of workplace complaints among Chinese employees and to develop a scale to measure them, drawing on the theory of work adjustment. We first obtained 49 items regarding employees' complaints following rigorous item generation and refinement procedures. Then, we conducted a survey with convenience sampling and obtained a sample of 268 employees. The exploratory factor analysis based on this sample generated a six-factor solution that explained 65.85% of the variance. The six factors include four person-environment (P-E) interactional factors, namely, dissatisfaction due to (a) interpersonal relationships; (b) management systems; (c) work conditions; and (d) authoritarian leadership; and two P-E misfit factors, namely, perceived misfit regarding (e) work content; and (f) job responsibilities. Furthermore, we obtained another sample of 349 employees through snowball sampling, on which we further validated the six-correlated-factor solution through confirmatory factor analysis. This study contributes to the literature by identifying causes of Chinese employees' complaints different from those attributed to their counterparts in Western cultures. This outcome particularly reveals that “dissatisfaction with interpersonal relationships” with colleagues was the leading cause of complaints among Chinese employees, rather than the “misfit between employees' needs and organizational rewards” revealed by Western culture-based studies. Both our findings and the scale we developed have practical implications for companies that employ Chinese employees.
Understanding the associations between Psychological Mindedness and Social Perspective Taking in Young People

This study was set to examine the associations between psychological mindedness (PM) and social perspective taking (SPT). Previous literature suggests that these constructs contribute to an enhanced performance in the mental health profession, possibly because they are featured by a developed theory of mind. An online questionnaire was developed using the Balanced Index of Psychological Mindedness (BIPM) and two adapted versions to measure PM about other people as well as to measure PM about thoughts and behavior. A reduced version of the Situational Test of Emotional Understanding and a newly developed scale were used to measure SPT. Responses from 135 participants aged between 18 and 32 were collected. A one-way ANOVA test showed that women scored higher than men in the understanding ability of SPT. Multiple hierarchical regression analysis revealed that PM about self could not predict any dimensions of SPT (understanding and importance) while PM about other people could predict the importance dimension of SPT as well as the construct as a whole. Overall this study provides insight on to the relationship between these two theoretically-linked constructs. The practical implications of the findings and the limitations of the study are discussed with directions for future research.
BASS. XXVI. DR2 Host Galaxy Stellar Velocity Dispersions

We present new central stellar velocity dispersions for 484 Sy 1.9 and Sy 2 from the second data release of the Swift/BAT AGN Spectroscopic Survey (BASS DR2). This constitutes the largest study of velocity dispersion measurements in X-ray-selected obscured active galactic nuclei (AGN) with 956 independent measurements of the Ca ii H and K λ3969, 3934 and Mg I λ5175 region (3880–5550 Å) and the calcium triplet region (8350–8730 Å) from 642 spectra mainly from VLT/X-Shooter or Palomar/DoubleSpec. Our sample spans velocity dispersions of 40–360 km s1, corresponding to 4–5 orders of magnitude in black hole mass (M BH = 105.5−9.6 M ⊙), bolometric luminosity (L bol ∼ 1042–46 erg s−1), and Eddington ratio (L/L Edd ∼ 10−5 to 2). For 281 AGN, our data and analysis provide the first published central velocity dispersions, including six AGN with low-mass black holes (M BH = 105.5−6.5 M ⊙), discovered thanks to high spectral resolution observations (σ inst ∼ 25 km s−1). The survey represents a significant advance with a nearly complete census of velocity dispersions of hard X-ray–selected obscured AGN with measurements for 99% of nearby AGN (z < 0.1) outside the Galactic plane (∣b∣ > 10°). The BASS AGN have much higher velocity dispersions than the more numerous optically selected narrow-line AGN (i.e., ∼150 versus ∼100 km s−1) but are not biased toward the highest velocity dispersions of massive ellipticals (i.e., >250 km s−1). Despite sufficient spectral resolution to resolve the velocity dispersions associated with the bulges of small black holes (∼104–5 M ⊙), we do not find a significant population of super-Eddington AGN. Using estimates of the black hole sphere of influence from velocity dispersion, direct stellar and gas black hole mass measurements could be obtained with existing facilities for more than ∼100 BASS AGN.
Application of Finite Strain Consolidation Theory for Engineering Design and Environmental Planning of Mine Tailings Impoundments

A knowledge of the consolidation behavior of mine tailings, during and after deposition, is important in estimating final impoundment capacity, rate and pore fluid expulsion during and after deposition and post-deposition (reclamation) behavior. This paper describes three case histories where finite strain consolidation theory was used for the engineering design and environmental planning of impoundments. Four materials are considered: sulfide tailings remaining from copper and zinc extraction, and gold tailings from three different ore bodies.
Explore the Potential Ingredients for Detoxification of Honey-Fired Licorice (ZGC) Based on the Metabolic Profile by UPLC-Q-TOF-MS

Licorice is well known for its ability to reduce the toxicity of the whole prescription in traditional Chinese medicine theory. However, honey-fired licorice (ZGC for short), which is made of licorice after being stir-fried with honey water, is more commonly used for clinical practice. The metabolism in vivo and detoxification-related compounds of ZGC have not been fully elucidated. In this work, the chemical constituents in ZGC and its metabolic profile in rats were both identified by high ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). The network pharmacology was applied to predict the potential detoxifying ingredients of ZGC. As a result, a total of 115 chemical compounds were identified or tentatively characterized in ZGC aqueous extract, and 232 xenobiotics (70 prototypes and 162 metabolites) were identified in serum, heart, liver, kidneys, feces, and urine. Furthermore, 41 compounds absorbed in serum, heart, liver, and kidneys were employed for exploring the detoxification of ZGC by network pharmacology. Ultimately, 13 compounds (five prototypes including P5, P24, P30, P41 and P44, and 8 phase Ⅰ metabolites including M23, M47, M53, M93, M100, M106, M118, and M134) and nine targets were anticipated to be potential mediums regulating detoxification actions. The network pharmacology analysis had shown that the ZGC could detoxify mainly through regulating the related targets of cytochrome P450 and glutathione. In summary, this study would help reveal potential active ingredients in vivo for detoxification of ZGC and provided practical evidence for explaining the theory of traditional Chinese medicine with modern technology.
The Impact of Board Size on Green Innovation in China’s Heavily Polluting Enterprises: The Mediating Role of Innovation Openness

Among the many reasons to encourage enterprises to implement green innovation, external factors such as market mechanisms and policy regulation both have the greatest probability of failure. Therefore, the idea of exploring ways to promote green innovation from internal factors has gradually attracted attention. This study is based on an internal perspective to explore the relationship between board size, openness, and green innovation by using data from the heavily polluting enterprises listed in China’s A-share market from 2015 to 2020. The regression results show that board size has a significant positive impact on green innovation, and the openness breadth plays a partial mediating role. This indicates that more board members are conducive to the implementation of green innovation strategies, as well as expanding the innovation openness breadth, so as to obtain external knowledge and resources to promote green innovation. Through further heterogeneity analysis, we found that the above relationship is more significant in state-owned enterprises. Finally, this study provides new theoretical evidence for the debate over whether board size promotes or inhibits green innovation. Furthermore, it provides a path and practical guidance for enterprises to implement green innovation more effectively by relying on their directors’ networks and increasing their own openness.
Sarcoma Common MHC-I Haplotype Restricts Tumor-Specific CD8+ T Cell Response

Simple Summary Immunotherapy targeting immune checkpoint pathways have recently attracted great attention in cancer treatment, but better strategies are needed to identify patients likely to benefit from it. The major histocompatibility complex (MHC) class I expression in cancer cells greatly influences the outcome of T cell-mediated immunotherapy. Here, we determined the prevalent HLA class I allelic variants in a sarcoma population. We characterized patient CD8+ T-cells and demonstrated low cytolysis to autologous tumor cells. Moreover, we used a co-culture model of autologous T-cells and PD-L1-deficient or positive biopsies of rare sarcomas to determine whether HLA-I influences tumor survival. Abstract The major histocompatibility complex (MHC) class I expression in cancer cells has a crucial impact on the outcome of T cell-mediated cancer immunotherapy. We now determined the HLA class I allelic variants and their expression in PD-L1-deficient and positive rare sarcoma tissues. Tumor tissues were HLA-I classified based on HLA-A and -B alleles, and for class II, the HLA-DR-B by Taqman genomic PCRs. The HLA-A24*:10-B73*:01 haplotype was the most common. A general down-regulation or deletion of HLA-B mRNA and HLA-A was observed, compared to HLA-DR-B. HLA-I was almost too low to be detectable by immunohistochemistry and 32% of grade III cases were positive to PD-L1. Functional cytotoxic assays co-culturing patient biopsies with autologous T cells were used to assess their ability to kill matched tumor cells. These results establish that deletion of HLA-I loci together with their down-regulation in individual patient restrict the autologous lymphocyte cytotoxic activity, even in the presence of the immune checkpoint blocking antibody, Nivolumab. Additionally, the proposed cytotoxic test suggests a strategy to assess the sensitivity of tumor cells to T cell-mediated attack at the level of the individual patient.
Strong convergence theorem for two asymptotically quasi-nonexpansive mappings with errors in Banach space

In this paper, we study strong convergence of common fixed points of two asymptotically quasi-nonexpansive mappings and prove that if $K$ is a nonempty closed convex subset of a real Banach space $E$ and let $ S, T\colon K\to K $ be two asymptotically quasi-nonexpansive mappings with sequences $ \{u_n\}$, $\{v_n\}\subset [0,\infty) $ such that $ \sum_{n=1}^{\infty}u_n $$ \begin{cases} x_{n+1}& = (1-\alpha_n)x_n + \alpha_nS^ny_n + l_n \\ y_n &= (1-\beta_n)x_n + \beta_nT^nx_n + m_n, \quad \forall n\in N \end{cases} $$ where $ \{l_n\}_{n=1}^{\infty},\{m_n\}_{n=1}^{\infty} $ are sequences in $K$ satisfying $ \sum_{n=1}^{\infty}\Vert l_n\Vert
Impact of Leavening Agent and Wheat Variety on Bread Organoleptic and Nutritional Quality

Leavened bread can be made with different wheat varieties and leavening agents. Several studies have now demonstrated that each of these factors can play a role in bread quality. However, their relative impact in artisanal bread making remains to be elucidated. Here, we assessed the impact of two wheat varieties as well as the impact of sourdoughs and yeasts on multiple components of bread organoleptic and nutritional quality. Using a participatory research approach including scientists and bakers, we compared breads leavened with three different sourdoughs and three different commercial yeasts as well as a mix of sourdough and yeast. Breads were made from two wheat varieties commonly used in organic farming: the variety “Renan” and the landrace “Barbu”. Except for bread minerals contents that mostly depended on wheat variety, bread quality was mostly driven by the fermenting agent. Sourdough breads had lower sugar and organic acids contents. These differences were mostly attributable to lower amounts of maltose and malate. They also had a higher proportion of soluble proteins than yeast breads, with specific aroma profiles. Finally, their aroma profiles were specific and more diverse compared to yeast breads. Interestingly, we also found significant nutritional and organoleptic quality differences between sourdough breads. These results highlight the value of sourdough bread and the role of sourdough microbial diversity in bread nutritional and organoleptic quality.