Miracle-dz/UniFAR-FTUs huggingface dataset:
Parental mental health and child anxiety during the COVID‐19 pandemic in Latin America

Abstract This study examined parents’ (N = 10,141, 64% women) reports of their and their childrens’ depression, anxiety, and stress in Brazil, Mexico, Colombia and Argentina. The data come from the COVID‐19 Family Life Study (Ben Brik, 2020) and cohort recruited between April and December 2020. Participants completed online surveys that included the DASS‐21 and the Revised Children's Manifest Anxiety Scale. Our findings indicate that socio‐economically disadvantaged families fared worse in mental health during the early phases of the COVID‐19 pandemic compared with families with more social and economic resources. Mothers reported higher anxiety, depression, and stress compared with fathers. Parents of adolescents and adolescents fared worse than did families with younger children. Parental physical activity was associated with better parent and child mental health of anxiety symptoms. We discuss the need to address the adverse impacts of the COVID‐19 pandemic on mental health in families in Latin America via coordinated mental health and psychosocial support services that are integrated into the pandemic response currently and after the pandemic subsides.
ImmunoPET: Antibody-Based PET Imaging in Solid Tumors

Immuno-positron emission tomography (immunoPET) is a molecular imaging modality combining the high sensitivity of PET with the specific targeting ability of monoclonal antibodies. Various radioimmunotracers have been successfully developed to target a broad spectrum of molecules expressed by malignant cells or tumor microenvironments. Only a few are translated into clinical studies and barely into clinical practices. Some drawbacks include slow radioimmunotracer kinetics, high physiologic uptake in lymphoid organs, and heterogeneous activity in tumoral lesions. Measures are taken to overcome the disadvantages, and new tracers are being developed. In this review, we aim to mention the fundamental components of immunoPET imaging, explore the groundbreaking success achieved using this new technique, and review different radioimmunotracers employed in various solid tumors to elaborate on this relatively new imaging modality.
The Impact of Supervisory Management on Extension Agent Job Satisfaction

The relationship between a supervisor and his/her employee has a direct effect on the employee’s level of job satisfaction and decision to remain in the organization. Extension agent retention has been shown to increase when a positive relationship and supervisory support exist between an Extension agent and his/her supervisor. Herzberg’s Motivation-Hygiene Theory was used to examine relationships with and impacts of supervisor management on Extension agent job satisfaction. A census of Florida Extension agents were asked to describe their relationships with their County Extension Directors (CED). Significant positive relationships were found between agent job satisfaction and ratings of the hygiene factors of Effective Senior Management and Effective Supervisor. A significant positive relationship was also found between these two hygiene factors. A significant difference was found between effective senior management and the agents’ CEDs gender, with agents with male CEDs reporting higher average levels of satisfaction with Effective Senior Management than agents with female CEDs. Significant differences also existed between agents’ Effective Senior Management satisfaction and years of working relationship between agents and CEDs. Extension supervision and leadership training should be a focus of Extension administration as effective supervision and management have a positive impact on Extension agent job satisfaction.
In Vivo Quantitative Imaging of Glioma Heterogeneity Employing Positron Emission Tomography

Simple Summary Defining glioma heterogeneity represents a promising strategy to unravel the mechanisms behind therapy resistance and tumor recurrence. The current review provides a comprehensive overview of experimental and clinical data concerning the visualization and quantification of the tumor microenvironment heterogeneity using molecular imaging, with a special emphasis on positron emission tomography (PET). Abstract Glioblastoma is the most common primary brain tumor, highly aggressive by being proliferative, neovascularized and invasive, heavily infiltrated by immunosuppressive glioma-associated myeloid cells (GAMs), including glioma-associated microglia/macrophages (GAMM) and myeloid-derived suppressor cells (MDSCs). Quantifying GAMs by molecular imaging could support patient selection for GAMs-targeting immunotherapy, drug target engagement and further assessment of clinical response. Magnetic resonance imaging (MRI) and amino acid positron emission tomography (PET) are clinically established imaging methods informing on tumor size, localization and secondary phenomena but remain quite limited in defining tumor heterogeneity, a key feature of glioma resistance mechanisms. The combination of different imaging modalities improved the in vivo characterization of the tumor mass by defining functionally distinct tissues probably linked to tumor regression, progression and infiltration. In-depth image validation on tracer specificity, biological function and quantification is critical for clinical decision making. The current review provides a comprehensive overview of the relevant experimental and clinical data concerning the spatiotemporal relationship between tumor cells and GAMs using PET imaging, with a special interest in the combination of amino acid and translocator protein (TSPO) PET imaging to define heterogeneity and as therapy readouts.
CMV-Responsive CD4 T Cells Have a Stable Cytotoxic Phenotype Over the First Year Post-Transplant in Patients Without Evidence of CMV Viremia

Cytomegalovirus (CMV) infection is a known cause of morbidity and mortality in solid organ transplant recipients. While primary infection is controlled by a healthy immune system, CMV is never eradicated due to viral latency and periodic reactivation. Transplantation and associated therapies hinder immune surveillance of CMV. CD4 T cells are an important part of control of CMV reactivation. We therefore investigated how CMV impacts differentiation, functionality, and expansion of protective CD4 T cells from recipients of heart or kidney transplant in the first year post-transplant without evidence of CMV viremia. We analyzed longitudinal peripheral blood samples by flow cytometry and targeted single cell RNA sequencing coupled to T cell receptor (TCR) sequencing. At the time of transplant, CD4 T cells from CMV seropositive transplant recipients had a higher degree of immune aging than the seronegative recipients. The phenotype of CD4 T cells was stable over time. CMV-responsive CD4 T cells in our transplant cohort included a large proportion with cytotoxic potential. We used sequence analysis of TCRαβ to identify clonal expansion and found that clonally expanded CMV-responsive CD4 T cells were of a predominantly aged cytotoxic phenotype. Overall, our analyses suggest that the CD4 response to CMV is dominated by cytotoxicity and not impacted by transplantation in the first year. Our findings indicate that CMV-responsive CD4 T cells are homeostatically stable in the first year after transplantation and identify subpopulations relevant to study the role of this CD4 T cell population in post-transplant health.
On the Development of Turbulence

The stability of two-dimensional parallel flows of an incompressible fluid is investigated, based upon a study of the equation of Orr and Sommerfeld along the lines initiated by Heisenberg. The theory of Heisenberg is carefully examined and further developed to obtain several general and specific results on hydrodynamic stability. Most of the disputes in the existing theories are clearly brought out and carefully settled. It is further shown that all symmetrical and all boundary-layer types of velocity distributions are unstable above a certain minimum critical Reynolds number, whose approximate value can be easily calculated from equations (12.24) and (12.25) respectively. General characteristics of the curve of neutral stability are obtained (Fig. 9). Complete numerical calculations of this curve have been carried through for the plane Poiseuille flow and the Blasius flow. In the first case, the minimum critical Reynolds number is found to be 16000, based upon the maximun velocity and the width of the channel. In the second case, the number is 400, based upon the free stream velocity and the displacement thickness of the boundary layer. Physical interpretations of the results obtained are given, based upon the conservation of vorticity in a perfect fluid and its diffusion by viscous forces. Indications are also given to connect the stability theory with Taylor's theory of transition to turbulence. It is hoped that this work may remove all the doubts of applying the theory of small oscillations to the treatment of hydrodynamic stability using Navier-Stokes equations for an incompressible fluid.
The Impact of Non-caloric Sweeteners on Male Fertility: A Systematic Review and Narrative Synthesis in Rodent Models

Understanding the factors which influence fertility is essential for developing appropriate nutritional recommendations for couples trying to conceive. Non-caloric sweeteners (NCS) are increasing in the food chain and despite being no/low calorie, several adverse metabolic consequences have been attributed to their consumption. Their effects on reproduction have been relatively under-researched, particularly in males. This review aims to systematically review the literature for evidence of the effect of NCS on male fertility in rodents, with sperm parameters (sperm quantity and quality) assessed as primary outcomes. Given the lack of information available in humans this review has been carried out using evidence from rodent models. Risk of bias assessment was carried out using the Syrcle risk of bias tool. Nine studies met the inclusion criteria. Forty-four percent showed a negative effect of NCS on male reproductive parameters compared with controls. The effects of NCS on fertility have been conflicting and selected studies have been heterogeneous in relation to study design. It is unclear if NCS has an impact on male reproductive function. There is a need for randomized controlled trials using a standardized protocol for analysis, to formulate a clear message in terms of male fertility.
Thermal efficiency of different coverage materials in reduced models of animal husbandry facilities: a case study.

This study aimed to assess different combinations of coverage materials in reduced models of animal husbandry facilities based on thermal comfort indices. It was conducted in an experimental area of the Research Center in Ambience located in São Paulo State, Brazil (22°42′30′′ S and 47°38′00′′ W). The performance of ceramic and fiber-cement (white painted) tiles was assessed associated with two types of polypropylene commercial linings (lining A and B) installed below the roof, and a thermo-reflective screen (lining C) installed above the fiber-cement roof. Microclimatic assessment of distorted reduced-scale models was performed at 15-minute intervals by registering the air temperature, black globe temperature, relative humidity and air velocity. Subsequently, black globe humidity index, specific enthalpy, and radiant heat load were calculated. The experimental design was randomized block design with 5 treatments and 15 blocks (replications), totaling 75 experimental units. The reduced-scale models with lining B presented a reduction for all thermal comfort indices. Lining C, installed on the coverage, showed no upgrading of environmental thermal conditions. Thus, lining B presented a better thermal performance regardless the tile type.
Cadmium Sulfide Quantum Dots Adversely Affect Gametogenesis in Saccharomyces cerevisiae

In the last decades, nanotechnology-based tools have attracted attention in the scientific community, due to their potential applications in different areas from medicine to engineering, but several toxicological effects mediated by these advanced materials have been shown on the environment and human health. At present, the effects of engineered nanomaterials on gametogenesis have not yet been well understood. In the present study, we addressed this issue using the yeast Saccharomyces cerevisiae as a model eukaryote to evaluate the effects of cadmium sulfide quantum dots (CdS QDs) on sporulation, a process equivalent to gametogenesis in higher organisms. We have observed that CdS QDs cause a strong inhibition of spore development with the formation of aberrant, multinucleated cells. In line with these observations, treatment with CdS QDs down-regulates genes encoding crucial regulators of sporulation process, in particular, the transcription factor Ndt80 that coordinates different genes involved in progression through the meiosis and spore morphogenesis. Down-regulation of NDT80 mediated by CdS QDs causes a block of the meiotic cell cycle and a return to mitosis, leading to the formation of aberrant, multinucleated cells. These results indicate that CdS QDs inhibit gametogenesis in an irreversible manner, with adverse effects on cell-cycle progression.
Influence of the water jet system vs cavitron ultrasonic surgical aspirator for liver resection on the remnant liver

BACKGROUND Several methods, such as finger fracture, Pean crush, cavitron ultrasonic surgical aspirator (CUSA), and water jet (WJ), are used for hepatic parenchymal dissection in liver surgery. CUSA is the conventional method in Japan. WJ is a relatively novel method for parenchymal dissection. Although it has several advantages, such as lower volume of blood loss and shorter operative time, the effect of the WJ system for hepatic dissection on the remnant liver has not yet been investigated. AIM To investigate and compare the effect of the WJ method vs CUSA on the remnant liver cut surface. METHODS This observational study compared the two types of parenchymal transection methods (WJ vs CUSA) in liver surgery. In total, 24 and 40 patients who underwent hepatectomy using the WJ method and CUSA, respectively, were included in the analysis. Accordingly, the clinicopathological characteristics and clinical outcomes of 24 and 40 patients were compared. Furthermore, postoperative contrast-enhanced computed tomography (CT) scan was performed to assess the cut surface length of the remnant liver and the degenerative thickness of the areas with a reduced contrast effect in the dissected plane. Then, the two groups were compared. RESULTS On CT scan, the median areas of denaturation in the liver dissection planes were 522 (range: 109.5-1242) mm2 in the CUSA group and 324 (range: 93.6-1529) mm2 in the WJ group. The area did not significantly differ between the two groups; however, the denaturation thickness of the WJ group was significantly lower than that of the CUSA group [5.8 (range: 0.7-11.1) mm vs 3.3 (range: 1.7-10.4) mm, P < 0.001]. CONCLUSION The WJ group had significantly thinner contrast-enhanced areas in the post hepatectomy detached section than the CUSA group.
Generalized Acoustic Energy Density and Its Applications

Generalized Acoustic Energy Density and Its Applications Buye Xu Department of Physics and Astronomy Doctor of Philosophy The properties of acoustic kinetic energy density and total energy density of sound fields in lightly damped enclosures have been explored thoroughly in the literature. Their increased spatial uniformity makes them more favorable measurement quantities for various applications than acoustic potential energy density (or squared pressure), which is most often used. In this dissertation, a new acoustic energy quantity, the generalized acoustic energy density (GED), will be introduced. It is defined by introducing weighting factors, α and 1 − α, in the formulation of total acoustic energy density. With the additional degree of freedom, the GED can conform to the traditional acoustic energy density quantities, or be optimized for different applications. The properties and applications of the GED are explored in this dissertation. For enclosed sound fields, it was found that GED with α = 1/4 is spatially more uniform than the acoustic potential energy density, acoustic kinetic energy density, and the total acoustic energy density, which makes it a more favorable measurement quantity than those traditional acoustic energy density quantities for many indoor measurement applications. For some other applications, such as active noise control in diffuse field, different values of α may be considered superior. The numerical verifications in this research are mainly based on a hybrid modal expansion developed for this work, which combines the free field Green’s function and a modal expansion. The enclosed sound field is separated into the direct field and reverberant field, which have been treated together in traditional modal analysis. Studies on a point source in rectangular enclosures show that the hybrid modal expansion converges notably faster than the traditional modal expansions, especially in the region near the source, and introduces much smaller errors with a limited number of modes. The hybrid modal expansion can be easily applied to complex sound sources if the free field responses of the sources are known. Damped boundaries are also considered in this dissertation, and a set of modified modal functions is introduced, which is shown to be suitable for many damped boundary conditions.
Soil fertility of rice- blackgram cropping sequence as influenced by different organic sources of nutrients

Residual effects of organic manures on rice-blackgram cropping sequence, during 2017 and 2018 at Thoppur, Thirupparankundram, Madurai were studied at field levels. Twelve treatment combinations comprising various sources of nutrients (Green manure @ 6.25 t/ha, neem cake@250 kg/ha, Enriched FYM @1.0 t/ha, tamarind seed powder @ 100 kg/ha, vermicompost @ 4 t/ha, Panchagavya @ 3%, Multi varietal seed technique, herbal pest repellant spray @ 10%, state recommendation) in a Randomized Block Design with three replications laid out for rice, were used for rice fallow blackgram. The mean soil available N (345 kg/ha), phosphorous (33 kg ha-1) and potassium (310 kg/ha) of 2 cropping cycles were significantly superior with the application of green manure @ 6.25 t/ha along with split application of vermicompost in four equal splits @ 4 t/ha as basal, at active tillering, panicle initiation and flowering stages + Panchagavya @ 3 per cent as foliar spray twice at active tillering and panicle initiation stages. A similar trend was also observed with respect to soil chemical and biological properties viz., soil pH, organic carbon, fungi, bacteria and actinomycetes population in the same treatment. The results of present study confirm the benefits of organic sources of manures on the nutrient retention characteristic of soil and will be conducive to improve the soil fertility for achieving sustainable soil health. Bangladesh J. Bot. 51(2): 289-296, 2022 (June)
The Spectrum of Positiv Elliptic Operators and Periodic Geodesics

A device comprising an offset preventing liquid supply roller of a novel construction which is capable of supplying a suitable amount of offset preventing liquid in one operation to a fixing roller of an electrophotographic copying apparatus and remaining in sevice over a prolonged time by merely being maintained in contact with the fixing roller with a low force. The supply roller comprises a reservoir disposed in its central portion for containing therein a substantial amount of offset preventing liquid, and a liquid permeable material layer disposed outwardly of the reservoir and capable of being permeated with the offset preventing liquid for supplying to the fixing roller the offset preventing liquid which oozes therethrough.
Quality of Life of Adolescents Facing a Parental Illness: A Person-Oriented Approach

Studies that have investigated the health-related quality of life (HRQoL) of adolescents facing a parental illness showed inconsistent results, and none used a person-oriented approach allowing for a deeper understanding of their experience. The aim of this study was to compare the HRQoL of adolescents facing a parental illness to that of their peers, and to explore their HRQoL through a person-oriented approach. The sample consisted of 1324 adolescents recruited in secondary schools (11–15 years old). Adolescents completed questionnaires assessing sociodemographic characteristics, parental illness, HRQoL (KIDSCREEN-52), and academic performance and caring activities (MACA-YC18). Adolescents facing a parental illness showed significantly lower HRQoL than their peers on all dimensions. The cluster analysis yielded five patterns of HRQoL among adolescents facing a parental illness: Low HRQoL; High HRQoL; Moderate HRQoL with High Social Acceptance; High Well-Being, High Moods and Emotions, and High Social Support and Peers. These clusters differed according to demographics, the type of parental illness, illness perception, academic performance, and level of caring activities. The Low HRQoL cluster showed especially low academic performance and high level of caring activities. This multidimensional HRQoL evaluation thus helps to foreground the diversity of these adolescents’ experiences in order to better address their needs.
Genome-Wide Identification of RNA Editing Sites Affecting Muscle Development in Yak

Skeletal muscle growth and development is a complicated process that is regulated at multiple steps and by numerous myogenesis genes. RNA editing represents one of the events at the post-transcriptional level, which contributes to the diversity of transcriptome and proteome by altering the nucleotides of RNAs. However, RNA editing events in the skeletal muscle of yaks are still not well defined. This study conducted whole-genome RNA-editing identification in skeletal muscle of yaks at embryonic stage (ES) and adult stage (AS). We found a total of 11,168 unique RNA editing sites, most of which were detected in the intergenic region. After annotation, we totally identified 2,718 editing sites within coding regions, among which 858 were missense changes. Moreover, totally 322 editing sites in the 3′ untranslated regions (UTR) were also predicted to alter the set of miRNA target sites, indicating that RNA editing may be involved in translational repression or mRNA degradation. We found 838 RNA editing sites (involving 244 common genes) that are edited differentially in ES as compared to AS. According to the KEGG enrichment analysis, these differentially edited genes were mainly involved in pathways highly related to skeletal muscle development and myogenesis, including MAPK, AMPK, Wnt, and PI3K-Akt signaling pathways. Altogether, our work presents the first characterization of RNA editing sites within yak skeletal muscles on a genome-wide scale and enhances our understanding of the mechanism of skeletal muscle development and myogenesis.
Problems in CSF and Ophthalmic Disease Research

There has been significant interest and progress in the understanding of cerebrospinal fluid pressure and its relationship to glaucoma and other ophthalmic diseases. However, just as every physiologic fluid pressure fluctuates, cerebrospinal fluid pressure (CSFP) is similarly dynamic. Coupling this with the difficulty in measuring the pressure, there are many obstacles in furthering this field of study. This review highlights some of the difficulties in CSFP research, including fluid compartmentalization, estimation equations, and pressure fluctuation. Keeping these limitations in mind will hopefully improve the quality and context of this burgeoning field.