Miracle-dz/UniFAR-FTUs huggingface dataset:
Cellular Landscaping of COVID-19 and Gynaecological Cancers: An Infrequent Correlation

COVID-19 resulted in a mortality rate of 3–6% caused by SARS-CoV-2 and its variant leading to unprecedented consequences of acute respiratory distress septic shock and multiorgan failure. In such a situation, evaluation, diagnosis, treatment, and care for cancer patients are difficult tasks faced by medical staff. Moreover, patients with gynaecological cancer appear to be more prone to severe infection and mortality from COVID-19 due to immunosuppression by chemotherapy and coexisting medical disorders. To deal with such a circumtances oncologists have been obliged to reconsider the entire diagnostic, treatment, and management approach. This review will provide and discuss the molecular link with gynaecological cancer under COVID-19 infection, providing a novel bilateral relationship between the two infections. Moreover, the authors have provided insights to discuss the pathobiology of COVID-19 in gynaecological cancer and their risks associated with such comorbidity. Furthermore, we have depicted the overall impact of host immunity along with guidelines for the treatment of patients with gynaecological cancer under COVID-19 infection. We have also discussed the feasible scope for the management of COVID-19 and gynaecological cancer.
Characterisation of Nanoclay and Spelt Husk Microfiller-Modified Polypropylene Composites

Current research is devoted to the investigation of spelt husk (SH) and nanoclay-modified compatibilised polypropylene (PP) binary and ternary composites for injection-moulding applications. PP composites were obtained using twin-screw extrusion. The content of mechanically milled SH microfiller with aspect ratio within 2 and 6 was fixed at 40 wt. %, whereas the amount of nanoclay functional filler in the polypropylene matrix was changed in the range from 0.5 to 5 wt. %. Nanoclay filler was introduced in the polypropylene matrix either in the form of nanoclay powder (C) or as a masterbatch (M). Regular distribution of the clay nanofiller within the polymer matrix has been observed, disregarding its form and concentration. The effects of the individual or combined addition of SH microreinforcement and nanoclay fillers on the rheological, mechanical, calorimetric, and thermal properties of the developed PP composites were investigated. It is revealed that the addition of the nanoclay fillers insignificantly influences the viscosity of both PP nanocomposites and hybrid composites with SH. Additionally, for PP nanocomposites, remarkable increases in tensile and flexural modules and strength are observed by maintaining considerable ultimate deformations, mainly in the case of M-containing systems. Concomitantly, because of the addition of the nanoclay filler, the improvement in thermal stability of PP nanocomposites and PP hybrid composites with SH is observed. As a result of SH addition, considerable increases in tensile and flexural modules are also observed. Results of the research demonstrate the potential of the use of natural materials (agricultural residues and clay minerals) for the development of PP composites with increased stiffness and thermal properties.
Molecular Epidemiology in Amerindians of the Brazilian Amazon Reveals New Genetic Variants in DNA Repair Genes

Native American populations from the Brazilian Amazon have a low genetic diversity and a different genetic profile when compared to people from other continents. Despite this, few studies have been conducted in this group, and there is no description of their genetic data in the various currently existent international databases. The characterization of the genomic profile of a population not only has an impact in studies of population genetics, but also helps to advance diagnostic and therapeutic response studies, leading to the optimization of clinical applicability. Genetic variations in DNA repair genes have been associated with the modulation of susceptibility to various pathologies, as well as in their prognosis and therapy. This is the first study to investigate DNA repair genes in Amerindians from the Brazilian Amazon region. We investigated 13 important DNA repair genes in the exome of 63 Native Americans, comparing our results with those found in 5 continental populations, whose data are available in the Genome Aggregation Database. Our results showed that 57 variants already described in literature were differentially distributed in the Amerindian populations in relation to the continental populations, 7 of which have significant clinical relevance. In addition, 9 new variants were described, suggesting that they are unique to these populations. Our study reinforces the understanding that the Amazonian Native American population presents a unique genetic profile, and our findings may collaborate with the creation of public policies that optimize the quality of life of these groups as well as the Brazilian population, which presents a high degree of interethnic mixing with Amerindian groups.
Covid-19 Pandemic-Knowledge, Perception, Anxiety And Depression Among Frontline Healthcare Workers Of Ayub Teaching Hospital Abbottabad, Pakistan.

Background The COVID-19 pandemic is a viral infection that spreads through different mediums and has a high rate of mortality. At its initial stages, there is no particular medicine that can cure patients of COVID-19. The aim of the present study was to understand the COVID-19 knowledge, perception, and its effects in terms of anxiety and depression among frontline health care workers of Ayub Teaching Hospital, Abbottabad. Methods This cross-sectional study was conducted in Ayub Teaching Hospital, Abbottabad from June to July 2021 in which data was collected from 200 hospital healthcare workers who have performed duties in COVID isolation wards through standard questionnaire. SPSS version 24.0 was used for data analysis. Results Out of 200 participants in the study 100 (50.0%) were male. Regarding safety measures taken during COVID -19, 144 (72.0%) individuals reported that they have not been given training to handle known or suspected cases of COVID-19. Moderate anxiety and depression was found in 153 (76.5%) healthcare workers, mild in 25 (12.5%) and 22 (11.0%) had severe anxiety and depression at the time of COVID-19 pandemic. Conclusion This study revealed that a significant anxiety and depression was found in frontline healthcare workers during the COVID-19 pandemic. In addition, a more extensive study should be conducted which involves many other hospitals like Ayub Teaching Hospital.
Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer

Cancer-related opportunistic bacterial infections are one major barrier for successful clinical therapies, often correlated to the production of genotoxic factors and higher cancer incidence. Although dual anticancer and antimicrobial therapies are a growing therapeutic fashion, they still fall short when it comes to specific delivery and local action in in vivo systems. Nanoparticles are seen as potential therapeutic vectors, be it by means of their intrinsic antibacterial properties and effective delivery capacity, or by means of their repeatedly reported modulation and maneuverability. Herein we report on the production of a biocompatible, antimicrobial magneto-fluorescent nanosystem (NANO3) for the delivery of a dual doxorubicin–ofloxacin formulation against cancer-related bacterial infections. The drug delivery capacity, rendered by its mesoporous silica matrix, is confirmed by the high loading capacity and stimuli-driven release of both drugs, with preference for tumor-like acidic media. The pH-dependent emission of its surface fluorescent SiQDs, provides an insight into NANO3 surface behavior and pore availability, with the SiQDs working as pore gates. Hyperthermia induces heat generation to febrile temperatures, doubling drug release. NANO3-loaded systems demonstrate significant antimicrobial activity, specifically after the application of hyperthermia conditions. NANO3 structure and antimicrobial properties confirm their potential use in a future dual anticancer and antimicrobial therapeutical vector, due to their drug loading capacity and their surface availability for further modification with bioactive, targeting species.
The Presence of Minor Physical Anomalies of a Hand in Patients with Mental Disorders.

INTRODUCTION Minor physical anomalies (MPA) are subtle morphological deviations with little to none clinical significance that are developed prenatally and therefore could be an indicator of structural changes in the brain developing at the same time. Aim of this study was to determine whether the MPA of the hand can distinguish psychotic patients from patients with non-psychotic diagnoses as well as from the healthy individuals. SUBJECTS AND METHODS 100 consecutive patients from the University Hospital Center Zagreb, Department of psychiatry, were included in this case-control study along with 100 healthy control subjects. Investigators examined the dorsal and palmar side of the hand and were blind to the patient's diagnoses previous to the examination. Examined MPA included thenar crease, proximal transverse crease, proximal interphalangeal joint, eponychium of the middle digit, fingernail size and digital flexibility. RESULTS Results showed significant differences in the quantity of MPA between the patients and the control group, as well as differences between patients with psychosis and the healthy subjects. CONCLUSIONS Despite the fact that previous studies demonstrated characteristic distribution of specific MPA in schizophrenia, this study did not prove such results. Moreover, this study showed that all the MPA are equally common in both schizophrenia and other psychoses.
Geographical distribution of zebu breeds and their relationship with environmental variables and the human development index

: The environment is vital to the agricultural sector since it can cause adversities throughout the entire productive chain. This study evaluated the geographical distribution of zebu breeds in Brazil and correlated their occurrence with environmental variables and the human development index. Herds of purebred zebu cattle ( Bos indicus ) in Brazil were classified as beef, dairy, and dual-purpose breeds, and all breeds were spatialized in the ArcGIS program. Environmental (precipitation, temperature, relative humidity index) and the human development index (HDI) were examined. We conducted regression and logistic analyses. Zebu cattle showed a lower distribution in the Northeastern states compared to other locations, possibly due to harsh weather conditions, namely long periods of high temperatures and lower precipitation, directly affecting local livestock. Beef breeds were evenly spread throughout the country in regions influenced by environmental variables of higher precipitation, normalized difference vegetation index (NDVI), temperature, relative humidity (RH), and temperature humidity index (THI), as well as properties without smallholder farmers and rivers and streams with riparian vegetation. The regions for dual-purpose and dairy breeds were predominantly cultivated with cutting forages ( e.g. , sugarcane - Saccharum officinarum ), with the integration of crops, livestock and/or forestry ( i.e. , combining different activities in the same area) and areas with a rotational grazing system ( i.e. , grazing management), indicating a higher occupation in fertile lands. The Gir breed, the only dairy breed evaluated in this study, was seen in establishments with smallholder farmers, characterized by small to medium farms, and in regions at higher altitudes.
Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma

Background In a previous study, a total of 568 differentially expressed proteins including the signal peptidase SPC21 were identified from lung adenocarcinoma (LUAD) and paired normal lung tissues. In this study, the role of SPC21 in LUAD progression was investigated. Methods The relationships and protein-protein interaction network of proteins differentially expressed between paired LUAD samples and adjacent normal tissues samples were identified via the String and Pajek software, respectively. The expression levels of the hub protein SPC21 were analyzed in 84 LUAD-normal paired tissues via immunohistochemistry. The prognostic value of SPC21 mRNA was investigated in 478 LUAD patients from TCGA and GTEx datasets. siRNAs were used in A549 and NCI-H1299 cells to knockdown SPC21. The SPC21 biological function was evaluated using the CCK-8, EdU, plate colony formation, transwell, wound healing, and adhesion assays. Results Patients with lower SPC21 mRNA levels tended to have worse prognosis (overall survival) than those with higher mRNA levels. SPC21 expression was significantly downregulated in LUAD tumor tissues compared with that in paired normal tissues (P < 0.001). Functionally, SPC21 knockdown promoted cell growth, migration, and invasion. Further analyses showed that SPC21 inactivated Akt signaling, and the Akt inhibitor MK-2206 blocked the tumor-promoting effects of SPC21 knockdown. Conclusions SPC21 plays a tumor suppressor role in LUAD cells by targeting the PTEN-PI3K/Akt axis and might be used as a prognostic indicator and therapeutic target in LUAD patients.
Control of river discharge on large‐scale estuary morphology

Estuaries are dynamic landscapes with complex bar and channel patterns formed by interactions between tidal and fluvial currents. River discharge dampens the tidal wave, enhances the ebb flow, and supplies sediment to the estuary. However, it is largely unknown how river discharge influences overall estuary morphology. The objective of the current study is to quantify the control of river discharge on bar and channel dimensions and sediment transport throughout the estuary. To this end, a long‐term and large‐scale Delft3D‐2DH estuary model was designed with a suite of model runs undertaken where discharge systematically varied. Results show that tide‐dominated estuaries with significant river discharge can develop towards a dynamic equilibrium with a constant tidal prism through adjustment of channel dimensions to accommodate the supplied river discharge. It is essential to account for this morphodynamic adjustment when considering the transition from tide‐dominated estuaries to aggrading river‐dominated estuaries. After this transition, the estuary evolution depends on the discharge‐to‐width ratio. Tidal prism either decreases with higher river discharge as the tidal flow is dampened and the estuary aggrades, or increases when the estuary widens as it adjusts to the increase in total discharge. Additionally, results show that a higher river discharge increases the difference between the limit of flood‐dominant sediment transport and the limit of flow reversal, which has important implications for the preservation of the tidal signal in the stratigraphy. Estuary dimensions and channel patterns can be described as a function of river and tidal discharge. These findings indicate that the dynamic spatial component in numerical models is crucial in predicting trends in long‐term estuary morphology as well as in inverse predictions from stratigraphy.
Mental Health Impacts of Working from Home after COVID-19: Does Gender Matter?

Background: The COVID-19 pandemic has led to various social distancing practices such as mandatory working from home, which aim to reduce the spread of SARS-CoV-2. The purpose of this study was to compare the mental health impacts between men and women being forced to work from home following a COVID-19 outbreak.Methods: This study analyzed data collected from two rounds of surveys conducted in four cities in China: Beijing, Chengdu, Changsha, and Wuhan. A total of 940 individual responses were analyzed in this study. Multiple linear regression and ordinal logistic models were used to analyze the relationship between being forced to work from The analysis showed that being forced to work from home was associated with worse mental health in men, but not among women. Married men reported better mental health compared with unmarried men, while the association between marital status and mental health was the opposite in women. Mental health was worse among those in higher job positions for both men and women. In addition, being forced to work from home was also associated with worse mental health among young, high-income men, and highly educated women.Conclusions: The impacts of the COVID-19 pandemic are far-reaching and amy persist for years. Furthermore, the number of workers who choose to work from home is expected to increase. The findings of this study can inform policy-making that will improve the mental health of employees working from home, with particular attention to men forced to work from home.
Academic Procrastination in Undergraduate Students: Understanding the Role of Basic Psychological Need Satisfaction and Frustration and Academic Motivation

Procrastination is particularly prevalent in the post-secondary student population, with prevalence rates ranging between 70–95%. Students have consistently cited motivation, or a lack thereof, as one of the main sources of their procrastination. One of the most prominent theories explaining motivation is self-determination theory (SDT). Despite the direct links between motivation and procrastination, procrastination has been scarcely examined through the lens of SDT. The current study examined the relationship between basic psychological need (BPN), satisfaction and frustration, academic motivation, and academic procrastination. A sample of 617 undergraduate students completed an online questionnaire about their university experience. Data were analyzed using mediational structural equation models. Results suggested that academic motivation significantly mediated the relationship between BPN satisfaction and procrastination, but not the relationship between BPN frustration and procrastination. These results demonstrate the importance of satisfying the BPN of undergraduate students, as it may increase their academic motivation and, subsequently, reduce their procrastination.
Dosimetric Impact on the Flattening Filter and Addition of Gold Nanoparticles in Radiotherapy: A Monte Carlo Study on Depth Dose Using the 6 and 10 MV FFF Photon Beams

Purpose: This phantom study investigated through Monte Carlo simulation how the dose enhancement varied with depth, when gold nanoparticles (NPs) were added using the flattening filter-free (FFF) photon beams in gold NP-enhanced radiotherapy. Method: A phantom with materials varying from pure water to a mixture of water and gold NPs at different concentrations (3–40 mg/mL) were irradiated by the 6 and 10 MV flattening filter (FF) and FFF photon beams. Monte Carlo simulations were carried out to determine the depth doses along the central beam axis of the phantom up to a depth of 40 cm. The dose enhancement ratio (DER) and FFF enhancement ratio (FFFER) were calculated based on the Monte Carlo results. Results: The DER values were found decreased with an increase of depth and increase of NP concentration in the phantom. For the maximum NP concentration of 40 mg/mL, the DER values decreased 6.9, 12, 4.6 and 7.2% at a phantom depth from 2 to 40 cm, using the 6 MV FF, 6 MV FFF, 10 MV FF and 10 MV FFF photon beams, respectively. The maximum DER values for the 6 MV beams were 1.08 (FF) and 1.14 (FFF), while those for the 10 MV beams were 1.04 (FF) and 1.07 (FFF). When the FF was removed from the linear accelerator head, the FFFER showed a more significant increase of dose enhancement for the 6 MV beams (1.057) than the 10 MV (1.031). Conclusion: From the DER and FFFER values based on the Monte Carlo results, it is concluded that the dose enhancement with depth was dependent on the NP and beam variables, namely, NP concentration, presence of FF in the beam and beam energy. Dose enhancement was more significant when using the lower photon beam energy (i.e., 6 MV), FFF photon beam and higher NP concentration in the study.
E-Learning Model to Identify the Learning Styles of Hearing-Impaired Students

Deaf students apparently experience hardship in conventional learning; however, despite their inability to hear, nothing can stop them from reading. Although they perform impressively in memorizing the information, their literacy and reading capability still appear to be weak since they lack the chance to revise by listening and practicing repetitively. Currently, the teaching media for deaf students are quite rare and inadequate, forcing them to face difficulties in integrating new knowledge, even though most of the contents are in a form of written, printed, downloaded, or even accessible via an e-learning platform. However, it is crucial to bear in mind that each learner is different. There is evidence showing that some learners prefer particular methods of learning, also known as learning preferences or learning styles. Thus, the present study reports the sequence of learning styles obtained by using a modified VRK + TSL model that categorized students based on their learning styles. We also propose four different ways of teaching using content-adaptive learning styles, namely visual, reading/writing, kinesthetic, and Thai sign language. Based on personal preferences and the principle of universal design under synthesized learning, an e-learning model was developed to identify deaf learners’ learning styles. The objective is to provide e-learning to identify the learning styles of hearing-impaired students and to respond with up-to-date e-learning materials that can be used anywhere and at any time. These materials must support the education of deaf students. As a result, learners have increased efficiency and increased learning outcomes.
Magnetic field amplification in collapsing, non-rotating stellar cores

Context. The influence of magnetic fields on stellar core collapse and explosion is not well explored. It depends on the possibility to amplify the pre-collapse fields. Without rotation this can happen by compression, convection, the standing accretion shock instability, and the accumulation and growth of Alfven waves in the accretion flows. Aims. We investigate such amplification mechanisms of the magnetic field during the collapse and post-bounce evolution of the core of a non-rotating 15 solar mass star with varied initial field strengths, taking into account the microphysical equation of state and neutrino physics crucial for supernova cores. Methods. We perform simulations of ideal MHD with neutrino transport in axisymmetry. The transport of electron neutrinos and antineutrinos is treated with a new scheme that solves the energy-dependent set of radiation energy and momentum equations in 2d by using an analytic closure relation. Results. The magnetic field undergoes amplification by turbulent flows. We find indications for amplification by interacting waves in accretion streams. The fields can reach up to equipartition with the velocity field. Very high magnetic field strengths require very strong pre-collapse fields and are able to shape the post-bounce flow, leading to a pattern dominated by low-order multipoles. Such models are closest to a successful explosion. Conclusions. Magnetic fields can build up to interesting strengths even in non-rotating collapsing stellar cores. Starting with fields in the pre-collapse core as predicted by present stellar evolution models, typical neutron star fields emerge, whereas stronger progenitor fields lead to fields of magnetar strength. Only in the latter case the fields have dynamical effects on the flows in the supernova core. However, in none of our 2D simulations, we find an explosion until 500 ms post-bounce.