Miracle-dz/UniFAR-FTUs huggingface dataset:
Knocking-Down CD147/EMMPRIN Expression in CT26 Colon Carcinoma Forces the Cells into Cellular and Angiogenic Dormancy That Can Be Reversed by Interactions with Macrophages

Metastasis in colorectal cancer is responsible for most of the cancer-related deaths. For metastasis to occur, tumor cells must first undergo the epithelial-to-mesenchymal transition (EMT), which is driven by the transcription factors (EMT-TFs) Snail, Slug twist1, or Zeb1, to promote their migration. In the distant organs, tumor cells may become dormant for years, until signals from their microenvironment trigger and promote their outgrowth. Here we asked whether CD147/EMMPRIN controls entry and exit from dormancy in the aggressive and proliferative (i.e., non-dormant) CT26 mouse colon carcinoma cells, in its wild-type form (CT26-WT cells). To this end, we knocked down EMMPRIN expression in CT26 cells (CT26-KD), and compared their EMT and cellular dormancy status (e.g., proliferation, pERK/pP38 ratio, vimentin expression, expression of EMT-TFs and dormancy markers), and angiogenic dormancy (e.g., VEGF and MMP-9 secretion, healing of the wounded bEND3 mouse endothelial cells), to the parental cells (CT26-WT). We show that knocking-down EMMPRIN expression reduced the pERK/pP38 ratio, enhanced the expression of vimentin, the EMT-TFs and the dormancy markers, and reduced the proliferation and angiogenic potential, cumulatively indicating that cells were pushed towards dormancy. When macrophages were co-cultured with both types of CT26 cells, the CT26-WT cells increased their angiogenic potential, but did not change their proliferation, state of EMT, or dormancy, whereas the CT26-KD cells exhibited values mostly similar to those of the co-cultured CT26-WT cells. Addition of recombinant TGFβ or EMMPRIN that simulated the presence of macrophages yielded similar results. Combinations of low concentrations of TGFβ and EMMPRIN had a minimal additive effect only in the CT26-KD cells, suggesting that they work along the same signaling pathway. We conclude that EMMPRIN is important as a gatekeeper that prevents cells from entering a dormant state, and that macrophages can promote an exit from dormancy.
On a boom and bust year class cycle

We motivate and describe a class of nonlinear Leslie matrix models for semelparous populations, like cicadas and Pacific salmon. We then focus on a Cushing-inspired special case for which one can show rigorously that a heteroclinic boundary cycle exists and attracts nearby orbits for a certain range of parameters. Along the way we formulate some open problems concerning a carrying simplex and global behaviour.
Synergistic Antibacterial Proficiency of Green Bioformulated Zinc Oxide Nanoparticles with Potential Fosfomycin Synergism against Nosocomial Bacterial Pathogens

The drug resistance of bacterial pathogens causes considerable morbidity and death globally, hence there is a crucial necessity for the development of effective antibacterial medicines to address the antibacterial resistance issue. The bioprepared zinc oxide nanoparticles (ZnO-NPs) were prepared utilizing the flower extract of Hibiscus sabdariffa and then characterized using different physicochemical techniques. The antibacterial effectiveness of the bioprepared ZnO-NPs and their synergism with fosfomycin were evaluated using disk diffusion assay against the concerned pathogens. Transmission electron microscopy (TEM) investigation of the bioprepared ZnO-NPs showed that their average particle size was 18.93 ± 2.65 nm. Escherichia coli expressed the highest sensitivity to the bioinspired ZnO-NPs with a suppressive zone of 22.54 ± 1.26 nm at a concentration of 50 µg/disk, whereas the maximum synergistic effect of the bioinspired ZnO-NPs with fosfomycin was noticed against Klebsiella pneumoniae strain with synergism ratio of 100.29%. In conclusion, the bioinspired ZnO-NPs demonstrated significant antibacterial and synergistic efficacy with fosfomycin against the concerned nosocomial bacterial pathogens, highlighting the potential of using the ZnO NPs-fosfomycin combination for effective control of nosocomial infections in intensive care units (ICUs) and health care settings. Furthermore, the biogenic ZnO-NPs’ potential antibacterial action against food pathogens such as Salmonella typhimurium and E. coli indicates their potential usage in food packaging applications.
Distributed optimal resource allocation with second‐order multi‐Agent systems

This paper studies the resource allocation problems with second‐order multi‐agent systems under the constraint of the global network resource. A novel distributed continuous‐time algorithm, which only uses the local information, is proposed. By using matrix transform and differential inequality technique, the exponential convergence is obtained under the undirected and connected graph. To reduce energy consumption and communication costs, a distributed event‐triggered algorithm is designed. It is proved that not only this algorithm converges exponentially to the optimal allocation, but also the event‐triggered time sequence does not exhibit Zeno‐behavior. Finally, numerical examples illustrate the effectiveness of theoretical results.
Stability analysis of uncertain time-delay systems with saturating actuator

The stabilization problem of uncertain time-delay systems with a saturating actuator is considered. These uncertainties may be linear or nonlinear, but only the upper bounds are known. The properties of norm and comparison theorem are employed to investigate the robust stability condition which assure asymptotic stability rather than ultimate boundedness of trajectories. Moreover, an algorithm is proposed to synthesize a dynamic feedback controller for guaranteeing the asymptotic stability of the uncertain time delay saturating systems. The sufficient condition for robust stability of input delay constrained systems subjected to parametric perturbations is also derived. The result obtained eliminates the need to solve the Riccati equation. The stability criterion is delay-dependent and less conservation than the delay-independent criteria and delay-dependent criterion when delays are small. Finally, simulation examples are given to demonstrate the application of the authors' results.
Using technology acceptance model to discuss factors in university employees’ behavior intention to apply social media

In order to evaluate the problem of employees using social networking technology for business purposes, the technology acceptance model will be applied. The purpose of the study is to establish the levels of impact exerted by the elements that influence the intentions of individuals working in the university to utilize social media. Employees in the university’s connections between “organizational support,” “colleague support,” “self-efficacy,” “technology capacity,” “perceived usefulness,” “perceived ease of use,” and “behavior intention” are acknowledged as factors in this study. It was possible to get a total of 247 copies that were legitimate. For the purpose of inferential statistics, the partial least squares structural equation modeling method was applied. The data indicate that colleague support and technological capabilities do not have any impact on how easily something may be used or how valuable it is thought to be. On the other hand, organizational support and self-efficacy have a favorable influence on the perceived ease of use, but they have no effect on the perceived effectiveness of the tool. Additionally, while perceived usefulness does not have any influence on behavioral intention, perceived simplicity of use does have a favorable effect on behavioral intention.
Understanding Online Registry Facilitators and Barriers Experienced by Black Brain Health Registry Participants: The Community Engaged Digital Alzheimer’s Research (CEDAR) Study

Background Failure of Alzheimer’s disease and related diseases (ADRD) research studies to include and engage Black participants is a major issue, which limits the impact and generalizability of research findings. Little is known about participation of Black adults in online ADRD-related research registries. Objectives As part of the Community Engaged Digital Alzheimer’s Research (CEDAR) Study, this study aims to increase our understanding of facilitators and barriers of Black adults to participating in ADRD-related online registries, as well as to understand their preferences for communication channels. Design, Setting, Participants, Measurements We invited all Black participants enrolled in the Brain Health Registry (BHR) to complete a cross-sectional online survey. The survey consisted of rating scales and open-text questions asking about their attitudes towards brain health research, reasons for joining and continuing to participate in BHR, difficulties with participating, and preferences for modes of contact and website usage. Results Of all invited Black BHR participants (N=3,636), 198 (5.5%) completed the survey. The mean age was 58.4 (SD=11.3), mean years of education were 16.3 (SD=2.4), and 85.5% identified as female. Reported facilitators for joining and continuing to participate in BHR were personal interest (e.g., learning more about own brain health) and altruism (e.g., helping research). Among additional registry features which could encourage return, receiving feedback or scores about BHR tasks was rated the highest. Of those who found BHR participation difficult (21%), the most frequent reason was time burden. The most preferred way of receiving study information was via email. Participants reported that the websites that they used the most were YouTube and Facebook. Discussion The results of our study can inform the development of culturally-responsive registry features and engagement efforts to improve inclusion and participation of Black adults in online ADRD research. Providing participants with feedback about their registry performance and reducing the number of registry tasks are among the recommended strategies.
Status Quo and Future Perspectives of Molecular and Genomic Studies on the Genus Biomphalaria—The Intermediate Snail Host of Schistosoma mansoni

Schistosomiasis, or also generally known as bilharzia or snail fever, is a parasitic disease that is caused by trematode flatworms of the genus Schistosoma. It is considered by the World Health Organisation as the second most prevalent parasitic disease after malaria and affects more than 230 million people in over 70 countries. People are infected via a variety of activities ranging from agricultural, domestic, occupational to recreational activities, where the freshwater snails Biomphalaria release Schistosoma cercariae larvae that penetrate the skin of humans when exposed in water. Understanding the biology of the intermediate host snail Biomphalaria is thus important to reveal the potential spread of schistosomiasis. In this article, we present an overview of the latest molecular studies focused on the snail Biomphalaria, including its ecology, evolution, and immune response; and propose using genomics as a foundation to further understand and control this disease vector and thus the transmission of schistosomiasis.
Color Stability of Rhodium-Coated Archwire after Immersion in Mouthwashes

Background Is to evaluate the color stability of rhodium-coated aesthetic archwires after immersion in two types of mouthwashes (fluoridated and nonfluoridated), study the effect of immersion time, and to compare the effect of these solutions on color stability of the aesthetic archwires. Materials and Methods 35 rhodium-coated aesthetic archwires were prepared and divided two halves, arranged in seven strips (each strip contains 10 wires) and immersed in Deionized water, Sidrazac and Biofresh solution. The measurements of the color have been carried out through a computed spectrophotometer based on Commission Internationale de I'Eclairage L∗a∗b∗system, and color variations (ΔE∗), color measurements were repeated 7 and 21 days after immersion in the solution. Statistical analyses include mean, standard deviation, minimum, maximum, and inferential statistics which include ANOVA and Tukey (HSD) for testing for any statistically significant differences in light reflection of the groups; t-test was used to test for differences in immersion time intervals. The significance level has been set at P ≤ 0.05. Results Both types of mouthwashes resulted in color changes in different degrees and a higher color instability amount has been noted with Sidrazac-fluoridated mouthwashes, The color change amount has been increased with the time being statistically higher in 3 weeks of immersion, while there is nonsignificant color change after immersion in the Biofresh mouthwash. Conclusion Rhodium-coated archwire shows high color changes in Sidrazac-fluoridated mouthwashes and nonsignificant color change after immersion in the Biofresh mouthwash.
Galaxy redshifts in an equatorial field in Virgo and the spatial distribution of local Lyman alpha clouds

New redshifts are presented for 51 galaxies which lie in a narrow strip along the celestial equator in the range 11 h 15 m ≤ R. A. ≤ 14 h 15 m. The redshifts are derived from a mixture of optical and H I spectra; for the latter subset (37 galaxies) H I fluxes and line widths are also presented. The spatial distribution of the galaxies in this field is compared with the locations of the large H I cloud discovered by Giovanelli and Haynes and the nearby Ly α clouds recently found toward 3C 273. One of the two Ly α clouds in the Local Supercluster appears to be associated with a spiral galaxy, althrough the angular and physical separations (42 arcmin and 180 kpc) are large. The other nearby Ly α cloud and the large H I cloud appear to be more isolated
The Third Basis Function Relevant to an Approximate Model of Neutral Particle Transport in Ducts

Abstract A prescription for the third basis function relevant to an approximate model of neutral particle transport in ducts is given. When a third basis function is included in the model, the full five-variable differential equation that describes time-independent particle transport in a duct is reduced to a three-group-like transport equation in two variables (one spatial, one angular). Numerical results based on the discrete ordinates method for a series of test cases are compared with results from a suitably modified version of the MCNP code to assess the gain in precision of the model with three basis functions relative to previous versions of the model that make use of only one or two basis functions.
Surface plasmon mediated transmission of subwavelength slits at THz frequencies

We present measurements and a numerical modeling that elucidate the role of surface plasmons in the resonant transmission of a subwavelength slit in a conducting material. By using THz time domain spectroscopy, we determine the Fabry--P\'erot transmission resonances for a single slit formed from a wafer of a semiconductor with a surface plasma frequency in the THz frequency range. We measure large redshifts in the resonant frequencies close to the surface plasma frequency, which are 50% lower than the resonance frequencies expected well below the surface plasma frequency. This is an effect attributed to the coupling of plasmons on the adjacent surfaces of the slit.
High power LHCD experiments in JET

The new Lower Hybrid Current Drive (LHCD) system has come into operation in JET in the 1994/95 experimental campaign. In this paper, results from high power experiments are presented. Power in excess of 7 MW and a maximum energy of 46 MJ have been coupled to divertor plasmas. Full current drive up to 3 MA has been achieved with LHCD alone; the CD efficiency increases with electron temperature up to 0.26 1020 A/W m−2. Current profile control experiments up to 3 MA have resulted in suppression of the sawtooth activity. At low density peaked electron temperature profiles with Te(0) in excess of 8 keV, have been observed. Experiments of combined LH profile and high performance discharges (Hot‐Ion H‐mode) will be discussed.
Bearing capacity of shallow foundations in transversely isotropic granular media

The main focus in this work is on the assessment of bearing capacity of a shallow foundation in an inherently anisotropic particulate medium. Both the experimental and numerical investigations are carried out using a crushed limestone with elongated angular‐shaped aggregates. The experimental study involves small‐scale model tests aimed at examining the variation of bearing capacity as a function of the angle of deposition of the material. In addition, the results of a series of triaxial and direct shear tests are presented and later employed to identify the material functions/parameters. The numerical part of this work is associated with the development and implementation of a constitutive framework that describes the mechanical response of transversely isotropic frictional materials. The framework is based on the elastoplasticity and accounts for the effects of strain localization and inherent anisotropy of both the deformation and strength characteristics. The results of numerical simulations are compared withthe experimental data. A parametric study is also carried out aimed at examining the influence of various simplifications in the mathematical framework on its predictive abilities. Copyright © 2009 John Wiley & Sons, Ltd.
A Guide to Molecular Characterization of Genotype II African Swine Fever Virus: Essential and Alternative Genome Markers

African swine fever is a contagious viral disease that has been spreading through Europe and Asia since its initial report from Georgia in 2007. Due to the large genome size of the causative agent, the African swine fever virus (ASFV), the molecular epidemiology, and virus evolution are analyzed by employing different markers. Most of these markers originate from single nucleotide polymorphisms or disparities in the copy number of tandem repeat sequences observed during the comparisons of full genome sequences produced from ASFVs isolated during different outbreaks. Therefore, consistent complete genome sequencing and comparative analysis of the sequence data are important to add innovative genomic markers that contribute to the delineation of ASFV phylogeny and molecular epidemiology during active circulation in the field. In this study, the molecular markers currently employed to assess the genotype II ASFVs circulating in Europe and Asia have been outlined. The application of each of these markers to differentiate between ASFVs from related outbreaks is described to implement a guideline to their suitability for analyzing new outbreaks. These markers do not signify the complete repertoire of genomic differences between ASFVs, but will be beneficial when analyzing the first outbreaks in a new region or a large number of samples. Furthermore, new markers must be determined via complete genome sequence analyses for enabling in-depth insights into the molecular epidemiology of ASFV.
Aerodynamic Resuspension of Particles Due to a Falling Flat Disk

In this article, computational fluid dynamics (CFD) is used to compute the unsteady, compressible flow caused by a flat falling circular disk. CFD results are coupled with a particle trajectory model to determine particle trajectories for different particle sizes and examine which particles are trapped or ejected from the closing gap. CFD results show that the normalized radial velocity profiles are self similar for different Reynolds numbers based on the gap height, and that flow compressibility results in a density increase toward the center of the disk for decreasing gap height. To efficiently couple CFD results with the particle trajectory model, a regression model representing both the velocity field and density variation inside the gap is developed and coupled with a particle detachment model. Particle trajectories are shown to be sensitive to the flow compressibility and must be taken into account. The escaped and trapped particle distribution is computed for a thin mono-layer of Arizona Test Dust under the disk. The simulations show that higher impact velocities tend to cause more of the heavier and larger particles to be trapped under the disk because they are catapulted from the floor and are quickly driven down again by the descending disk.
Elastic and inelastic conductance in Co-Fe-B/MgO/Co-Fe-B magnetic tunnel junctions

A systematic analysis of the bias voltage and temperature dependence of the tunneling magnetoresistance (TMR) in Co-Fe-B/MgO/Co-Fe-B magnetic tunnel junctions with barrier thickness ${t}_{B}$ between 1.8 and 4.0 nm has been performed. The resistance measured at low temperature in the parallel state shows the expected exponential increase with increasing barrier thickness. The low-temperature TMR amplitude of about 300% is quite similar for all MgO thicknesses. This is in accordance with microstructural investigations by transmission electron microscopy, which do not give hints to a reduction in the barrier quality with increasing MgO thickness. Both the junction resistance and TMR decrease with increasing temperature and bias voltage. In general, the decrease is much stronger for thicker barriers, e.g., a decrease in the TMR by a factor of 13.4 from 293% at 15 K to 21.9% at 300 K was observed for ${t}_{B}=4.0\text{ }\text{nm}$ compared to a reduction by only a factor of 1.6 for ${t}_{B}=1.8\text{ }\text{nm}$. This behavior can be described self-consistently for all barrier thicknesses within a model that extends the magnon-assisted tunneling model by adding an inelastic, unpolarized tunneling contribution. Furthermore we discuss our results in the framework of a recent model by Lu et al. [Phys. Rev. Lett. 102, 176801 (2009)] claiming that polarized hopping conductance becomes important for larger MgO thickness.
A concise analytical treatment of elastic‐plastic bending of a strain hardening curved beam

Plane stress and plane strain analytical solutions to partially plastic deformation of a curved beam are presented. The beam has a narrow rectangular cross section and it is subjected to couples at its end sections prevailing pure bending conditions. The analysis is based on Tresca's yield criterion, its associated flow rule and linear strain hardening material behavior. The solutions are verified in comparison to the ones available in the literature. It is shown that plane stress and plane strain solutions agree well in the elastic and in the elastic‐plastic deformation stages. It is also observed that the changes in the dimensions of the beam as it deforms are negligibly small.
Experimental study of relative intensity noise of multimode vertical-cavity surface-emitting lasers

We have performed an experimental investigation of the RIN spectra of multimode 1550 nm VCSELs. Several types of multi-transverse mode VCSELs have been considered. The first one emits in two transverse modes for large values of the bias current. Both modes are linearly polarized and have parallel polarizations. Two resonance peaks appear in the noise spectra of the individual modes and total power of the VCSEL in agreement with previous theoretical studies (A. Valle et al, IEEE J. Quantum Electron, vol. 40, 597, 2004). We have measured the frequencies corresponding to both peaks as a function of the bias current. We have obtained a similar dependence to the one found in the previous work. The second VCSEL type corresponds to a laser emitting at three different transverse modes for large values of the bias current. Similar behaviors are found while the bias current is small. Emission in three transverse modes with different polarizations is accompanied by the appearance of additional peaks in the noise spectra. It is suggested that the VCSEL polarization plays an important role in determining the multi-peaked structure of noise spectra. That is confirmed by measuring with another two-transverse mode VCSEL showing polarization instabilities in both transverse modes. It is shown that large values of the bias current applied to this VCSEL result in a complex dynamics characterized by the appearance of many additional peaks in the noise spectra.