Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognosis Analysis of Delayed Call Time for Chest Pain in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Direct Percutaneous Coronary Intervention

To describe the impact of delayed call time for chest pain in the salvage of ST-segment elevation myocardial infarction (STEMI) patients and its associated independent risk factors, and to identify risk factors associated with cumulative morbidity and mortality in STEMI patients at 4 years after percutaneous coronary intervention (PCI). Retrospective analysis of 398 patients diagnosed with STEMI and treated with emergency PCI within 24 hours of symptom onset in Fuyang People's Hospital from April 2018 to April 2021. The enrolled patients were divided into ≤60 minutes group (193 cases), and > 60 minutes group (205 cases), according to the delayed call time of patients with chest pain. Analysis of basic clinical data, rescue time, and major cardiovascular adverse events in the 2 groups. Multifactorial logistic regression analysis of independent correlates of delayed chest pain calls and Cox proportional risk regression modeling of risk factors for cumulative morbidity and mortality at 4 years after surgery. Compared to the delayed call time ≤ 60 minutes group, the > 60 minutes group had a higher proportion of females, a history of diabetes, rural remote areas, and farmer occupation (P < .05). Binary logistic regression analysis shows the history of diabetes and female as independent risk factors for delayed call time >60 minutes for chest pain. In the delayed call time ≤60 minutes group, the time from symptom onset-to-balloon (S0-to-B) and from symptom onset-to-first medical contact (SO-to-FMC) were smaller than in the delayed call time >60 minutes group (P < .05). The sum of postinfarction angina and major cardiovascular adverse events was lower in the group with delayed call time ≤60 minutes than in the group with delayed call time >60 minutes (P < .05). The Kaplan-Meier survival curve and the survival curve without the occurrence of major adverse cardiovascular events were statistically significant in both groups (P < .05). Multifactorial Cox regression analysis showed that delayed call time for chest pain >60 minutes, left main + 3 branch lesions, and cardiac function Killip ≥ III were all risk factors for cumulative morbidity and mortality at 4 years after PCI in patients with STEMI. Delayed call time for chest pain >60 minutes, left main + 3 branch lesions, and cardiac function Killip ≥ III are all risk factors for cumulative morbidity and mortality in STEMI patients at 4 years after PCI. Reducing the delayed call time for chest pain can improve the long-term prognosis of patients.
On the validity of the local constant field approximation in nonlinear Compton scattering

In the calculation of probabilities of physical processes occurring in a background classical field, the local constant field approximation (LCFA) relies on the possibility of neglecting the space-time variation of the external field within the region of formation of the process. This approximation is widely employed in strong-field QED as it allows to evaluate probabilities of processes occurring in arbitrary electromagnetic fields starting from the corresponding quantities computed in a constant electromagnetic field. Here, we demonstrate that the usual condition of validity of the LCFA in nonlinear Compton scattering, which only depends on the parameters of the external laser field, is quantitatively and qualitatively insufficient for describing the low-energy part of the emitted photon probability. In addition to their conceptual importance, these findings provide the theoretical tools to investigate quantitatively the role of low-energy photons in strong-field QED as well as to scrutinize the numerical schemes employed to interpret present and upcoming experiments in this field.
The asymptotic solution of linear differential systems : applications of the Levinson theorem

Asymptotically diagonal systems - the Levinson Theorem, coefficient matrices of Jordan type two-term differential equations - the Liouville-Green asymptotic formulae, application of the Hartman-Wintner Theorem, equations of Euler type equations of self-adjoint type resonance and non-resonance.
CARBAMAZEPINE INDUCED STEVENS-JOHNSON SYNDROME- A CASE REPORT

Stevens Johnson’s syndrome is an exfoliative dermatitis with severe erosions of atleast two mucosal surfaces including extensive necrosis of oral and nasal mucosa and purulent conjunctivitis,but less commonly involving vaginal, urethral, gastro intestinal or respiratory mucosal membranes. The Stevens-Johnson syndrome (SJS) is a rare immune-complex-mediated hypersensitivity disorder which affects 7 cases per million persons per year. This article describes a case study of a 12 year old female patient who was admitted to the tertiary care hospital,Chennai (India) with chief complaints of fever,malaise,sore throat,flu like symptoms and heavy body pain since 4 days. Burning sensation,edema,erythema of lips & buccal mucosa followed by development of bullae,ulcerations,hemorrhagic gusting since 2 days. Past history of medication revealed early clinical course of Carbamazepine for seizure prior to admission to the hospital. Based on signs and symptoms,with causality assessment analysis diagnosis of drug induced Stevens Johnson syndrome was confirmed. In the scarcity of evidence of effective treatment, patient was managed with symptomatic therapy and supportive care. As Stevens- Johnson syndrome is a potentially fatal multiorgan disease with a strong etiologic link to some medications, one must have a high index of suspicion to be able to diagnose and treat patients with SJS in time and must therefore consider Stevens-Johnson syndrome as a potential complication of treatment.
Influence of Slco2b1‐knockout and SLCO2B1‐humanization on coproporphyrin I and III levels in rats

Coproporphyrin (CP) I and III are byproducts of haem synthesis currently investigated as biomarkers for drug–drug interactions involving hepatic organic anion transporting polypeptide (OATP) 1B transporters. Another hepatically expressed OATP‐member is OATP2B1. The aim of this study was to test the impact of OATP2B1, which specifically transports CPIII, on CP serum levels, applying novel rat models.
Broad impact of adverse childhood experiences on postpartum maternal mental health, child‐rearing behaviors, and child development in Japan

Emerging research points to the existence of the intergenerational transmission of the impact of adverse childhood experiences (ACEs). 1 ACEs, especially in females, cause not only poor lifelong physical and mental health in victims themselves, but also problematic parenting behavior leading to increased offspring ACEs and poor developmental outcomes. 1 – 5 However, research so far has primarily focused on the in ﬂ uence of the number of ACEs while the impact of the types of ACEs remains unclear. For instance, whereas the presence of any ACEs has been associated with postpartum suicidal ideation, 2 the presence of three or more 3 and four or more 4 ACEs has been associated with postpartum depression and anxiety. Other studies have treated ACEs as a continuous variable and shown that increasing ACEs are associated with more mental health and child development problems. 5 It remains unclear what type of ACEs account for the detrimental effect or if all ACEs are equally hurtful.
On the differential variational inequalities of parabolic‐elliptic type

We consider a model of infinite dimensional differential variational inequalities formulated by a parabolic differential inclusion and an elliptic variational inequality. The existence of global solution and global attractor for the semiflow governed by our system is proved by using measure of noncompactness. Copyright © 2017 John Wiley & Sons, Ltd.
Rapid and automated lipid profiling by nuclear magnetic resonance spectroscopy using neural networks

Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for quantitative metabolomics; however, quantification of metabolites from NMR data is often a slow and tedious process requiring user input and expertise. In this study, we propose a neural network approach for rapid, automated lipid identification and quantification from NMR data. Multilayered perceptron (MLP) networks were developed with NMR spectra as the input and lipid concentrations as output. Three large synthetic datasets were generated, each with 55,000 spectra from an original 30 scans of reference standards, by using linear combinations of standards and simulating experimental‐like modifications (line broadening, noise, peak shifts, baseline shifts) and common interference signals (water, tetramethylsilane, extraction solvent), and were used to train MLPs for robust prediction of lipid concentrations. The performances of MLPS were first validated on various synthetic datasets to assess the effect of incorporating different modifications on their accuracy. The MLPs were then evaluated on experimentally acquired data from complex lipid mixtures. The MLP‐derived lipid concentrations showed high correlations and slopes close to unity for most of the quantified lipid metabolites in experimental mixtures compared with ground‐truth concentrations. The most accurate, robust MLP was used to profile lipids in lipophilic hepatic extracts from a rat metabolomics study. The MLP lipid results analyzed by two‐way ANOVA for dietary and sex differences were similar to those obtained with a conventional NMR quantification method. In conclusion, this study demonstrates the potential and feasibility of a neural network approach for improving speed and automation in NMR lipid profiling and this approach can be easily tailored to other quantitative, targeted spectroscopic analyses in academia or industry.
Decomposing the Gap in Contraceptive Use Among Female Adolescents and Young Women Aged 15-24 in India: An Analysis of Appended Datasets of NFHS-4 and 5

Purpose Owing to the reproductive health needs of the budding adolescent and young population, the present study aims to determine the factors associated with and decomposing the gap in contraceptive use among adolescents and young women in India. Design Cross sectional design. SettingThe present study is based in India using the appended datasets (IV and V rounds) of the Indian Demographic Health Survey (DHS), also known as National Family Health Survey (NFHS) conducted in 2015-16 and 2019-21. Sample The adequate sample size was 475,294 adolescents and young women in NFHS-4 and 229,705 in NFHS-5, totaling 704,999 adolescents (appended for NFHS-4 and 5) for the present study. Measures Sociodemographic, sexual and reproductive history and contraceptive measures. Analysis Descriptive statistics, chi-square tests, and a binary logistic regression model were executed. Additionally, a decomposition technique called Fairlie decomposition was employed to identify the primary causes of the difference in the prevalence of contraceptive use between the two survey periods. Results Almost 96% of young women aged 15-24 knew about contraception, but only 12% used it. Regression analysis revealed that contraceptive use was associated with higher age (AOR 1.09), higher education (AOR 1.28), married adolescents (AOR 4.08), richest wealth quantile (AOR 2.95), joint decision making (AOR 4.40), knowledge of ovulatory cycle (AOR 1.47), interaction with a health worker about any methods of family planning (AOR 3.29) and three and above children ever born (AOR 18.54). Decomposition analysis showed that factors like decision-making of contraception, age, interaction with family planning worker, the intention of last pregnancy, place of residence and age at first sex contributed to increasing the probability of contraceptive use from NFHS-4 to 5. Conclusion A target-based approach dedicated to understanding the mindset of adolescents and keeping up with their unique needs is the need of the hour.
Insufficient measles antibody protection in 6‐month‐old Malawian infants: Reconsider vaccination schedule?

Measles vaccination is currently recommended at 9 months, since maternal antibodies are supposed to protect infants until that age. In this study of 6‐month‐old Malawian infants 98.3% (58/59) had non‐protective IgG levels against measles, irrespective of HIV exposure. Anticipating the first dose at 6 months could be considered.
Sexual functioning, sexual enjoyment, and body image in Norwegian breast cancer survivors: a 12-year longitudinal follow-up study and comparison with the general female population

Abstract Background Given the scarcity of evidence concerning the long-term sexual health of breast cancer (BC) survivors (BC-Pop), we aimed to assess how BC treatments affect short- and long-term sexual functioning, sexual enjoyment, and body image, and compare with aged-matched women in the Norwegian general population (F-GenPop). Material and Methods The 349 patients in BC-Pop treated at Trondheim University Hospital in 2007–2014, were assessed in clinical controls at the hospital; before starting radiotherapy (T1, baseline), immediately after ending radiotherapy (T2), and after 3, 6, and 12 months (T3–T5), and at a long-term follow-up 7–12 years after baseline (T6). Meanwhile, F-GenPop included 2254 age-matched women in the Norwegian general population. The impact of BC treatment on sexual functioning was examined using a Linear Mixed Model. Sexual functioning, sexual enjoyment, and body image were assessed with the EORTC′s QLQ-BR23 scales and compared between the populations in the four age groups (30–49, 50–59, 60–69, and 70+ years) using means with 95% confidence intervals and Student t-test. Linear regression, adjusted for age and comorbidity was applied to estimate individual scores. Result BC survivors treated with mastectomy had overall lower sexual functioning than patients who had received breast-conserving surgery (p = 0.017). Although BC survivors treated with chemotherapy had lower sexual functioning than those treated without chemotherapy at T1–T5 (p = 0.044), both groups showed the same level of functioning at T6. BC-Pop exhibited significantly poorer sexual functioning (p < 0.001), lower sexual enjoyment (p < 0.05), and better body image (p < 0.001) than F-GenPop in all age groups. Conclusion The impact of specific BC treatments on sexual functioning was modest; only mastectomy had a persistent negative influence. Nevertheless, all age groups in BC-Pop displayed significantly poorer sexual functioning than F-GenPop at both 12 months and up to 12 years after treatment.
DNA Methylation Signatures of Functional Somatic Syndromes: Systematic Review

ABSTRACT Objective Functional somatic syndromes (FSS) are highly prevalent across all levels of health care. The fact that they are characterized by medically unexplained symptoms, such as fatigue and pain, raises the important question of their underlying pathophysiology. Psychosocial stress represents a significant factor in the development of FSS and can induce long-term modifications at the epigenetic level. The aim of this review was to systematically review, for the first time, whether individuals with FSS are characterized by specific alterations in DNA methylation. Methods MEDLINE and PsycINFO were searched from the first available date to September 2022. The inclusion criteria were as follows: a) adults fulfilling the research diagnostic criteria for chronic fatigue syndrome, fibromyalgia syndrome, and/or irritable bowel syndrome; b) healthy control group; and c) candidate-gene or genome-wide study of DNA methylation. Results Sixteen studies (N = 957) were included. In candidate-gene studies, specific sites within NR3C1 were identified, which were hypomethylated in individuals with chronic fatigue syndrome compared with healthy controls. In genome-wide studies in chronic fatigue syndrome, a hypomethylated site located to LY86 and hypermethylated sites within HLA-DQB1 were found. In genome-wide studies in fibromyalgia syndrome, differential methylation in sites related to HDAC4, TMEM44, KCNQ1, SLC17A9, PRKG1, ALPK3, TFAP2A, and LY6G5C was found. Conclusions Individuals with chronic fatigue syndrome and fibromyalgia syndrome seem to be characterized by altered DNA methylation of genes regulating cellular signaling and immune functioning. In chronic fatigue syndrome, there is preliminary evidence for these to be implicated in key pathophysiological alterations, such as hypocortisolism and low-grade inflammation, and to contribute to the debilitating symptoms these individuals experience. Preregistration PROSPERO identifier: CRD42022364720.
Features of functional and dysfunctional CD8+ T cells to guide HIV vaccine development

Purpose of review CD8+ T cell responses are a key component of the host immune response to human immunodeficiency virus (HIV) but vary significantly across individuals with distinct clinical outcomes. These differences help inform the qualitative features of HIV-specific CD8+ T cells that we should aim to induce by vaccination. Recent findings We review previous and more recent findings on the features of dysfunctional and functional CD8+ T cell responses that develop in individuals with uncontrolled and controlled HIV infection, with particular emphasis on proliferation, cytotoxic effector function, epitope specificity, and responses in lymph nodes. We also discuss the implications of these findings for both prophylactic and therapeutic T cell vaccine development within the context of T cell vaccine trials. Summary The induction of HIV specific CD8+ T cell responses is an important goal of ongoing vaccine efforts. Emerging data on the key features of CD8+ T cell responses that distinguish individuals who spontaneously control from those with progressive disease continues to provide key guidance.
Polynomials‐based summation inequalities and their applications to discrete‐time systems with time‐varying delays

This paper proposes a novel summation inequality, say a polynomials‐based summation inequality, which contains well‐known summation inequalities as special cases. By specially choosing slack matrices, polynomial functions, and an arbitrary vector, it reduces to Moon's inequality, a discrete‐time counterpart of Wirtinger‐based integral inequality, auxiliary function‐based summation inequalities employing the same‐order orthogonal polynomial functions. Thus, the proposed summation inequality is more general than other summation inequalities. Additionally, this paper derives the polynomials‐based summation inequality employing first‐order and second‐order orthogonal polynomial functions, which contributes to obtaining improved stability criteria for discrete‐time systems with time‐varying delays. Copyright © 2017 John Wiley & Sons, Ltd.
Carbohydrate Ingestion during Prolonged Cycling Improves Next-Day Time Trial Performance and Alters Amino Acid Concentrations

ABSTRACT Introduction Exercise with low carbohydrate availability increases protein degradation, which may reduce subsequent performance considerably. The present study aimed to investigate the effect of carbohydrate ingestion during standardized exercise with and without exhaustion on protein degradation and next-day performance. Methods Seven trained male cyclists (V̇O2max 66.8 ± 1.9 mL·kg−1·min−1; mean ± SEM) cycled to exhaustion (~2.5 h) at a power output eliciting 68% of V̇O2max (W68%). This was followed by repeating 1-min work/1-min recovery intervals at 90% of V̇O2max (W90%) until exhaustion. During W68%, cyclists consumed a placebo water drink (PLA) the first time and a carbohydrate drink (CHO), 1 g carbohydrate·kg−1·h−1, the second time. The participants performed the same amount of work under the two conditions, separated by at least 1 wk. A standardized diet was provided to the participants so that the two conditions were isoenergetic. To test the impact of carbohydrates on recovery, participants completed a time trial (TT) the next day. Results Carbohydrate ingestion maintained carbohydrate availability during W68% and W90%: total carbohydrate oxidation was significantly higher in CHO (P = 0.022), and plasma glucose concentration was maintained compared with PLA (P = 0.025). Next-day performance during TT was better after CHO ingestion (CHO, 41:49 ± 1:38 min; PLA, 42:50 ± 1:46 min; P = 0.020; effect size d = 0.23, small), as was gross efficiency (CHO, 18.6% ± 0.3%; PLA, 17.9% ± 0.3%; P = 0.019). Urinary nitrogen excretion (P = 0.897) and urinary 3-methylhistidine excretion (P = 0.673) did not significantly differ during the study period. Finally, tyrosine and phenylalanine plasma concentrations increased in PLA but not in CHO (P = 0.018). Conclusions Carbohydrate ingestion during exhaustive exercise reduced deterioration in next-day performance through reduced metabolic stress and development of fatigue. In addition, some parameters point toward less protein degradation, which would preserve muscle function.
WT1-mutated acute myeloid leukemia is sensitive to fludarabine-based chemotherapy and conditioning regimens

Abstract We conducted a retrospective analysis of WT1-mutated acute myeloid leukemia (AML) patients who underwent allogeneic stem cell transplant. Thirty-seven patients with WT1-mutated AML were identified. Primary induction failure (40%) and early relapse rate (18%) after idarubicin/cytarabine (7 + 3) chemotherapy were observed. All patients with induction failure subsequently achieved CR with additional chemotherapy. There was no significant difference between outcomes after myeloablative vs. reduced intensity (Fludarabine/Melphalan [Flu/Mel]) conditioning regimens. RFS but not OS was significantly better in patients who received FLAG-IDA prior to transplant and/or a fludarabine-containing conditioning. In an independent ex vivo study, WT1-mutated AML samples exhibited greater sensitivity to fludarabine (p = 0.026) and melphalan (p = 0.0005) than non-WT1-mutated AML samples while there was no difference between sensitivity to cytarabine. Our data favor using a fludarabine-based induction for AML with WT1 mutation instead of 7 + 3. Fludarabine conditioning regimens for alloHCT showed better RFS but not OS.
Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity

A large proportion of patients with multiple sclerosis (MS) have spasticity, which has a marked impact on their quality of life. Anecdotal evidence suggests a beneficial effect of cannabis on spasticity as well as pain. Recently, randomized, double-blind, placebo-controlled studies have confirmed the clinical efficacy of cannabinoids for the treatment of spasticity in patients with MS. Based on these data, nabiximols (Sativex), a 1:1 mix of Δ-9-tetrahydrocannabinol and cannabidiol extracted from cloned Cannabis sativa chemovars, received approval for treating MS-related spasticity in various countries around the globe. In this article we review the current understanding of cannabinoid biology and the value of cannabinoids as a symptomatic treatment option addressing spasticity in patients with MS.