Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of varying degrees of compression from elastic vs plastic wrap on quadriceps intramuscular temperature during wetted ice application

The aim of this study was to evaluate and compare the effectiveness of wetted ice bag, applied with high compression elastic wrap or held in place with low compression plastic wrap, on reducing vastus lateralis intramuscular temperature and skin surface temperature. Ten healthy male participants had wetted ice packs applied to a standardized area on the anterior aspect of the quadriceps simultaneously to both legs for 30 minutes. The ice pack was secured with high compression (elastic wrap) to the left anterior thigh (60.6 ± 8.1 mm Hg) and low compression (plastic wrap) to the right anterior thigh (15.5 ± 4.0 mm Hg). Intramuscular temperature (1 and 3 cm) and skin temperature of the vastus lateralis were measured continuously during a 10‐minute baseline period, 30‐minute treatment period, and a 60‐minute recovery period. No difference was observed between treatments in terms of the magnitude of reduction in intramuscular temperature at both 1 and 3 cm and skin temperature regardless of compression pressure (P > 0.05). Temperature upon conclusion of elastic wrap treatment was as follows: 17.8 ± 5.2°C at 1 cm and 23.1 ± 4.9°C at 3 cm; plastic wrap treatment: 17.9 ± 4.4°C at 1 cm and 24.5 ± 6.7°C at 3 cm. Plastic wraps may offer a practical alternative to elastic wraps for clinicians as they may be disposed of by the patient or athlete without having to stay at the treatment facility.
Feature-specific prediction errors for visual mismatch

Predictive coding (PC) theory posits that our brain employs a predictive model of the environment to infer the causes of its sensory inputs. A fundamental but untested prediction of this theory is that the same stimulus should elicit distinct precision weighted prediction errors (pwPEs) when different (feature-specific) predictions are violated, even in the absence of attention. Here, we tested this hypothesis using functional magnetic resonance imaging (fMRI) and a multi-feature roving visual mismatch paradigm where rare changes in either color (red, green), or emotional expression (happy, fearful) of faces elicited pwPE responses in human participants. Using a computational model for learning and inference, we simulated pwPE trajectories of a Bayes-optimal observer and used these to analyze changes in blood oxygen level dependent (BOLD) responses to changes in color and emotional expression of faces while participants engaged in a distractor task. Controlling for visual attention by eye-tracking, we found pwPE responses to unexpected color changes in the fusiform gyrus. Conversely, unexpected changes of facial emotions elicited pwPE responses in thalamo-cortico-cerebellar structures associated with emotion processing. Our results support a general role of PC across perception, from low-level to complex and socially relevant object features, and suggest that monitoring of the social environment occurs continuously and automatically, even in the absence of attention. Highlights Predictive coding (PC) implies that brain responses should reflect transient precision weighted prediction errors (pwPEs). By using fMRI we show that rare changes in color or emotional expression of human faces elicit pwPE responses in dedicated neuronal circuits with known specialization in processing color and emotion-related information, respectively. Our results demonstrate that physically identical stimuli elicit pwPEs in distinct neuronal circuits when different (feature-specific) predictions are violated, depending on current sensory expectations based on prior stimulus context. The demonstration of pwPEs in visual areas as well as in emotion processing structures lends experimental support to theoretical accounts of PC in color and social perception, respectively.
The Rate of CD4 T Cell Entry into the Lungs during Mycobacterium tuberculosis Infection Is Determined by Partial and Opposing Effects of Multiple Chemokine Receptors

The specific chemokine receptors utilized by Th1 cells to migrate into the lung during Mycobacterium tuberculosis infection are unknown. We previously showed in mice that CXCR3+ Th1 cells enter the lung parenchyma and suppress M. tuberculosis growth, while CX3CR1+ KLRG1+ Th1 cells accumulate in the lung vasculature and are nonprotective. ABSTRACT The specific chemokine receptors utilized by Th1 cells to migrate into the lung during Mycobacterium tuberculosis infection are unknown. We previously showed in mice that CXCR3+ Th1 cells enter the lung parenchyma and suppress M. tuberculosis growth, while CX3CR1+ KLRG1+ Th1 cells accumulate in the lung vasculature and are nonprotective. Here we quantify the contributions of these chemokine receptors to the migration and entry rate of Th1 cells into M. tuberculosis-infected lungs using competitive adoptive transfer migration assays and mathematical modeling. We found that in 8.6 h half of M. tuberculosis-specific CD4 T cells migrate from the blood to the lung parenchyma. CXCR3 deficiency decreases the average rate of Th1 cell entry into the lung parenchyma by half, while CX3CR1 deficiency doubles it. KLRG1 blockade has no effect on Th1 cell lung migration. CCR2, CXCR5, and, to a lesser degree, CCR5 and CXCR6 also promote the entry of Th1 cells into the lungs of infected mice. Moreover, blockade of G-protein-coupled receptors with pertussis toxin treatment prior to transfer only partially inhibits T cell migration into the lungs. Thus, the fraction of Th1 cell input into the lungs during M. tuberculosis infection that is regulated by chemokine receptors likely reflects the cumulative effects of multiple chemokine receptors that mostly promote but that can also inhibit entry into the parenchyma.
Loneliness as a Predictor of Work Disability Onset Among Nondisabled, Working Older Adults in 14 Countries

Objective: The objective of this study is to examine the relationship between loneliness and work disability and whether depression mediates the hypothesized relationship. Method: We draw on data from the 2013 and 2015 waves of the Survey of Health, Aging, and Retirement in Europe. We limited the sample to adults between the ages of 50 and 65 who were working and without work limitations in 2013, which consisted of 10,154 adults from 14 countries. We apply multivariate logistic regression and a binary mediation analysis with logistic regression to examine predictors of the onset of work disability in 2015. Results: Loneliness was predictive of future work disability onset when adjusting for other factors in the disablement process. Depression partly mediated the longitudinal relationship between loneliness and work disability. Discussion: The results indicate that addressing loneliness could mitigate the risk of depression and, in turn, work disability onset.
Airborne allergic contact dermatitis caused by Machaerium scleroxylon: Confirmation by in vivo and in vitro tests

Airborne agents can cause several skin reactions in occupational and less frequently in non-occupational settings, due to their strong irritant and/or sensitizing properties (1). Airborne allergic contact dermatitis is frequently caused by woods (2), above all tropical and subtropical woods containing many strong contact allergens, such as quinones (3). A case of airborne allergic contact dermatitis caused by Machaerium (M.) scleroxylon, confirmed by in vivo and in vitro tests, is described. This article is protected by copyright. All rights reserved.
Metabolic control by dehydroascorbic acid: Questions and controversies in cancer cells

For a long time, the effect of vitamin C on cancer cells has been a controversial concept. From Linus Pauling's studies in 1976, it was proposed that ascorbic acid (AA) could selectively kill tumor cells. However, further research suggested that vitamin C has no effect on tumor survival. In the last decade, new and emerging functions for vitamin C have been discovered using the reduced form, AA, and the oxidized form, dehydroascorbic acid (DHA), independently. In this review, we summarized the latest findings related to the effects of DHA on the survival and metabolism of tumor cells. At the same time, we put special emphasis on the bystander effect and the recycling capacity of vitamin C in various cellular models, and how these concepts can affect the experimentation with vitamin C and its therapeutic application in the treatment against cancer.
Two new xanthones, a new lignin, and twenty phenolic compounds from Smilax china and their NO production inhibitory activities

Abstract Two new xanthones smilone A (1), smilone B (2), and a new lignin smilgnin A (3) were isolated from the rhizomes of Smilax china L. , together with three known xanthones (4–6), four lignins (7–10), two flavones (11, 12), two stilbenoids (13, 14), and ten organic phenoloids (15–24). Of them, compounds 4–6 were isolated from the genus Smilax for the first time. The structures of 1–24 were elucidated by the extensive analysis of spectral data and compared with the literature. All compounds were evaluated for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Among them, compound 24 exhibited significant inhibitory activity against NO production (IC50 = 1.26 µM), while compounds 3, 6, and 7 showed weak activities at the concentration of 50 μM.
The effect of cognitive behavior intervention on alexithymia,coping style,life satisfaction and mental health in families of depression patients

Objective To investigating mental health statuses of depression patients'families and evaluate effect of cognitive behavior group intervention on them.Methods Depression patients'families and health control were selected respectively 100 persons.The families were randomly grouped into intervention group and control group with those in intervention group receiving cognitive behavior group intervention.The scales evaluating mental heahh included CHQ-12,TAS-20,TCSQ and LSIA.Results The ratio of CHQ≥4 in families group was significantly higher than that in health control group(P＜0.05),and there were notable difference for scores of TAS-20(52.36±10.71;47.59±10.06;t=3.25,P＜0.01),CHQ-12(2.97±2.41;2.01±1.95;t=3.10,P＜0.01)and LSIA(12.34±3.94;14.89±3.99;t=-4.54,P＜0.01)between two groups.The impact factors for mental health of families included whole duration and HAMD score of depression patients.and families'sex,age,marriage status,education duration,alexithymia,coping style.After psychological intervention,the scores of NC,LSIA were notably improved(P＜0.01)in intervention group,but there was no significant change in families control group.Conclusion The families of depression patients have more problem on emotional expression,life satisfaction and mental health,and cognitive behavior intervention is effective on coping style,life satisfaction and mental health. Key words: Depression; Family; Cognitive behavior treatment; Mental health
Numerical simulation of flow boiling heat transfer and pressure drop in a corrugated plate heat exchanger at low mass flux and vapor quality conditions

Abstract This article reports on a numerical study conducted to predict the flow boiling dynamics, heat and mass transfer, and pressure drop in corrugated plate heat exchangers. The conservation equations are discretized in the context of the finite volume method and solved using the mixture multiphase flow model. The Semi Mechanistic Wall boiling model, based on Chen’s method, is used to calculate the wall heat flux. Moreover, Lee’s model is adopted to compute the evaporation/condensation rate. Water is used as the working fluid and solutions are generated at low mass flux and vapor content for subcooled and saturated liquid water at the inlet. An experimental setup is developed, and measurements are performed to validate the numerical solution. The model shows good agreement with experimental data and with values obtained from available correlations for the two-phase heat transfer coefficient and pressure drop. Results indicate an increase in the heat transfer coefficient when the mass flux is increased, and wall and inlet flow temperatures are decreased. Further, the drop in pressure increases with an increase in the mass flux, wall temperature, and vapor quality. The flow boiling heat transfer is found to be in the nucleate boiling regime. Additional new insights on the complex flow boiling process are reported by utilizing contour plots of the mass evaporation rate, vapor fractions, and velocity vector fields.
Antibacterial and dye degradation potential of zero-valent silver nanoparticles synthesised using the leaf extract of Spondias dulcis.

The present study reports a simple and low cost synthesis of zero-valent silver nanoparticles (ZVSNPs) from silver nitrate using the leaf extract of Spondias dulcis. The ZVSNPs showed a unique peak at 420 nm in UV-vis spectrum. The SEM image portrayed cuboidal shaped particles. The EDX spectrum designated the elemental silver peak at 3 keV. In XRD, a sharp peak at 32.47° denoted the existence of (1 0 1) lattice plane and the average crystallite size was calculated as 48.61 nm. The lattice parameter was determined as 0.39 nm. The FTIR spectra of the leaf extract and ZVSNPs showed shifts in the specific functional group bands which ascertained the involvement of phytoconstituents in the formation and capping of nanoparticles. The average hydrodynamic size was measured as 59.66 nm by DLS method. A low PDI, 0.187 witnessed the monodispersity. A negative zeta potential value of -15.7 mV indicated the negative surface charges of the nanoparticles. The bactericidal action of ZVSNPs was demonstrated against two pathogens S.typhimurium and E.coli during which a dosage dependent zone of inhibition results was observed. Additionally, the catalytic potential of ZVSNPs was examined for the degradation of methylene blue dye in which an accelerated degradation of the dye was observed.
The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T)

Abstract Aim: The aim of this study was to determine the prevalence of childhood psychopathologies in Turkey. Method: A nation-wide, randomly selected, representative population of 5830 children (6–13 years-old) enrolled as a 2nd,3rd or 4th grade student in 30 cities were evaluated for presence of a psychiatric or mental disorder by a Sociodemographic Form, Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), and DSM-IV-Based Screening Scale for Disruptive Behavior Disorders in Children and Adolescents scales. Impairment criterion was assessed via a 3 point-Likert scale by the parent and the teacher independently. Results: Overall prevalence of any psychopathology was 37.6% without impairment criterion, and 17.1% with impairment criterion. Attention-deficit hyperactivity disorder was the most frequent diagnosis, followed by anxiety (19.5% and 16.7% without impairment, 12.4% and 5.3% with impairment, respectively). Lower education level and presence of a physical or psychiatric problem of the parents were independent predictors of any psychopathology of the offspring. Conclusion: This is the largest and most comprehensive epidemiological study to determine the prevalence of psychopathologies in children and adolescents in Turkey. Our results partly higher than, and partly comparable to previous national and international studies. It also contributes to the literature by determining the independent predictors of psychopathologies in this age group.
A cross-sectional study of YouTube videos as a source of patient information about phototherapy and excimer laser for psoriasis

Abstract YouTube is increasingly utilized by patients for health information. We aimed to assess the educational quality of YouTube videos about phototherapy and excimer laser for psoriasis. A cross-sectional analysis of YouTube videos was conducted using the search terms psoriasis phototherapy and psoriasis laser. Of the 200 videos screened, 124 met inclusion criteria. Sixty-eight (54.8%) were generated by device manufacturers advertising their product, 35 (28.2%) by healthcare professionals, and 8 (6.5%) by patients delivering testimonials from experiences receiving therapy. Fourteen (11.2%) contained high-quality patient education content, 28 (22.5%) were fair quality, and 82 (66.1%) were low quality. Compared to videos generated by advertisers, those created by healthcare providers were of higher educational quality and more likely to be patient-directed. Neither the number of views nor interaction differed significantly among videos of varying educational quality, between videos presenting evidence-based versus non-evidence-based claims about psoriasis, and between videos conveying positive versus negative messages regarding medical consultation. Overall, the majority of YouTube videos about phototherapy and excimer laser advertise devices are of fair-to-low educational quality and are not patient-centric. The addition of more videos that accurately and holistically discuss patient-relevant aspects of these therapies may transform YouTube into a more effective resource for informing patient choices.
Effect of body position on qualitative and quantitative ultrasound assessment of gastric fluid contents

We assessed the impact of raising the upper section of the bed, and patient positioning, on ultrasound assessment of gastric fluid contents. We performed ultrasound examinations in 25 subjects lying on their back, left and right sides at bed angles of 0°, 30°, 45° and 90°; this was carried out while the subjects were fasted, and repeated 10 min after drinking ≥ 50 ml water. After drinking, gastric contents were detected more frequently in the 45° semirecumbent position compared with the supine and 30° positions. The diagnostic performance of the Perlas qualitative grading scale to detect gastric fluid volume > 1.5 ml.kg−1 was improved at 45°, compared with 0° and 30° angles. The use of a composite ultrasound grading scale at a 45° angle was associated with the best performance, with a sensitivity and specificity of 82%. Antral cross‐sectional area was significantly increased when measured in the right lateral position, but there was no effect of raising the bed. In conclusion, raising the upper section of the bed significantly affected qualitative assessment of gastric fluid contents. Further studies are required to determine the most appropriate composite ultrasound grading scale and bed angle for fast and reliable qualitative ultrasound detection of fluid volumes > 1.5 ml.kg−1.
Your Brain on Comics: A Cognitive Model of Visual Narrative Comprehension

Abstract The past decade has seen a rapid growth of cognitive and brain research focused on visual narratives like comics and picture stories. This paper will summarize and integrate this emerging literature into the Parallel Interfacing Narrative‐Semantics Model (PINS Model)—a theory of sequential image processing characterized by an interaction between two representational levels: semantics and narrative structure. Ongoing semantic processes build meaning into an evolving mental model of a visual discourse. Updating of spatial, referential, and event information then incurs costs when they are discontinuous with the growing context. In parallel, a narrative structure organizes semantic information into coherent sequences by assigning images to categorical roles, which are then embedded within a hierarchic constituent structure. Narrative constructional schemas allow for specific predictions of structural sequencing, independent of semantics. Together, these interacting levels of representation engage in an iterative process of retrieval of semantic and narrative information, prediction of upcoming information based on those assessments, and subsequent updating based on discontinuity. These core mechanisms are argued to be domain‐general—spanning across expressive systems—as suggested by similar electrophysiological brain responses (N400, P600, anterior negativities) generated in response to manipulation of sequential images, music, and language. Such similarities between visual narratives and other domains thus pose fundamental questions for the linguistic and cognitive sciences.
Genetic resiliency and the Black Death: No apparent loss of mitogenomic diversity due to the Black Death in medieval London and Denmark.

OBJECTIVES In the 14th century AD, medieval Europe was severely affected by the Great European Famine as well as repeated bouts of disease, including the Black Death, causing major demographic shifts. This high volatility led to increased mobility and migration due to new labor and economic opportunities, as evidenced by documentary and stable isotope data. This study uses ancient DNA (aDNA) isolated from skeletal remains to examine whether evidence for large-scale population movement can be gleaned from the complete mitochondrial genomes of 264 medieval individuals from England (London) and Denmark. MATERIALS AND METHODS Using a novel library-conserving approach to targeted capture, we recovered 264 full mitochondrial genomes from the petrous portion of the temporal bones and teeth and compared genetic diversity across the medieval period within and between English (London) and Danish populations and with contemporary populations through population pairwise ΦST analysis. RESULTS We find no evidence of significant differences in genetic diversity spatially or temporally in our dataset, yet there is a high degree of haplotype diversity in our medieval samples with little exact sequence sharing. DISCUSSION The mitochondrial genomes of both medieval Londoners and medieval Danes suggest high mitochondrial diversity before, during and after the Black Death. While our mitochondrial genomic data lack geographically correlated signals, these data could be the result of high, continual female migration before and after the Black Death or may simply indicate a large female effective population size unaffected by the upheaval of the medieval period. Either scenario suggests a genetic resiliency in areas of northwestern medieval Europe.
Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

Abstract Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch. , C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. Objectives: The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives. Methods: Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread. Results: Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR. Conclusions: As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.