Miracle-dz/UniFAR-FTUs huggingface dataset:
cancer. The tumor suppressor Apc controls planar cell polarities central to gut

J.-N. Freund and J.R. De Mey contributed equally to this paper. Correspondence to Jan R. De Mey: jan.de-mey@unistra.fr Abbreviations used in this paper: ACF, aberrant crypt foci; APC, adenomatous polyposis coli; BP, basal process; EdU, 5-ethynyl-2-deoxyuridine; LOBA, longitudinally oriented basal asymmetry; LOH, loss of heterozygosity; MIP, maximal intensity projection; OCD, oriented cell division; PCP, planar cell polarity; SC, stem cell; SI, small intestine; wt, wild type. Introduction
Institutional Knowledge at Singapore Management University Volatility spillovers and linkages in Asian stock markets

This paper examines the pattern of volatility transfers in Asian stock markets in the context of deepening global as well as regional financial integration. Diebold-Yilmaz spillover indexes are computed for the weekly return volatilities based on daily benchmark stock indexes of US, UK and ten Asian countries. We found the strengthening of overall volatility spillovers is not a temporary surge during the crisis but persisted after the crisis, even as the economic environment remained uncertain. We also provide evidence the susceptibility of individual Asian stock markets to inward volatility transfers is linked to its degree of openness. The observed general increase in outward volatility transfers since the onset of the crisis suggests the Asian bourses are becoming more important emitters of financial shocks. As for volatility linkages between Asian bourses and major stock markets, we found using rolling regressions a general pattern of relative dominance of the US stock market over the Japanese and Chinese bourses. However, the level of influence on Asian stock markets from the Chinese bourse in terms of volatility linkages, has risen to that of Japan but remains lower than that of the US.
The Rotational Spectrum of TiO2

The rotational spectrum of titanium dioxide (TiO2) has been detected by laser-ablation molecular beam Fourier transform microwave spectroscopy. Thirteen b-type rotational transitions up to J = 9 and Ka = 4 were measured for the most abundant isotopic species 48TiO2 in the frequency range 7-42 GHz with accuracies of 1-10 kHz, allowing for the precise determination of rotational and centrifugal distortion parameters. In addition, eight and six rotational transitions of the rare isotopic species 46TiO2 and 50TiO2, respectively, have been recorded in the same frequency range. From the derived spectroscopic parameters, rest frequencies of TiO2 can now be calculated to better than 1 km s−1 in equivalent radial velocity up to fairly high J and Ka at millimeter wavelengths, enabling radioastronomical searches for this stable, highly polar transition metal dioxide in space. Preliminary results of two searches for TiO2 in space are presented.
Chemical abundance analysis of symbiotic giants. RW Hya, SY Mus, BX Mon, and AE Ara

Symbiotic stars are the long period, binary systems of strongly interacting stars at the final stages of evolution which can be useful tool to understand the chemical evolution of the Galaxy and the formation of stellar populations. Knowledge of the chemical composition of the symbiotic giants is essential to advancing our understanding of these issues but unfortunately reliably determinations exist only in a few cases. We perform a program for detailed chemical composition analysis in over 30 symbiotic giants, based on the high resolution, near-IR spectra, obtained with Phoenix/Gemini South spectrometer. The methods of the standard LTE analysis is used to obtain photospheric abundances of CNO and elements around iron peak. Here we present results obtained for four objects: RW Hya, SY Mus, BX Mon, and AE Ara. Our analysis revealed a significantly sub-solar metallicity (Me/H ~ -0.75) for RW Hya, a slightly sub-solar metallicities (Me/H ~ 0.2-0.3) in BX Mon and AE Ara, and a near-solar metallicity in SY Mus. 12C/13C isotopic ratios are low in all cases, ranging from ~6 to ~10, and indicate that the giants have experienced the first dredge-up.
DMSO_A_251567 2443..2453

1Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, Australia; 2Caring Futures Institute and SHAPE Research Centre, Exercise Science and Clinical Exercise Physiology, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia; 3Recreation, Exercise, and Sport Science Department, Western State Colorado University, Gunnison, Colorado, USA; 4Immunopathology Group, Mater Research Institute The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia; 5Australian Infectious Disease Research Centre, University of Queensland, Brisbane, Queensland, Australia; 6Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia; 7K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Sor Trondelag, Norway Introduction: IL-22 may have a role in the alleviation of the metabolic syndrome (MetS) via protection of pancreatic beta and endothelial cells from oxidative and lipid-induced damage. We aimed to investigate the effects of moderate-intensity continuous training (MICT) and different volumes of high-intensity interval training (HIIT) on changes in circulating IL-22. Methods: This was a sub-study of the “Exercise in the prevention of Metabolic Syndrome” (EX-MET) a multi-center, randomized trial. This study used data collected at the Brisbane site. Thirty-nine individuals with MetS were randomized to one of three 16-wk interventions: 1) MICT (n=10, 30min at 60–70% HR peak, 5x/wk); 2) 4HIIT (n=13, 4x4min at 85–95% HR peak, interspersed with 3min of active recovery at 50–70% HR peak, 3x/wk); or 3) 1HIIT (n=16, 1x4min at 85–95% HR peak, 3x/wk). Serum IL-22 concentration was measured following a 12-hr fast via an enzyme linked immunosorbent assay, before and after the intervention. MetS severity, insulin resistance (IR), visceral adipose tissue (VAT), and cardiorespiratory fitness (CRF) were also measured via MetS z-score, HOMA-IR, dualenergy X-ray absorptiometry, and indirect calorimetry (maximal exercise test), respectively. Results: The median (IQR) IL-22% changes from preto post-intervention in the MICT, 4HIIT, and 1HIIT groups were −17% (−43.0% to 31.3%), +16.5% (−18.9% to 154.9%), and +15.9% (−28.7% to 46.1%), respectively. Although there were no significant between-group differences in IL-22 concentration change, there was a medium-to-large group × time interaction effect [F(2,35)=2.08, p=0.14, η=0.14]. Conclusion: Although there was no statistically significant between-group difference in IL-22 change, the study suggests that different exercise intensities may have opposing effects on IL-22 concentration in individuals with MetS.
The Journal of Educational Development Developing Collaboration-Based Supervision Model to Enhance the Professionalism of Early Childhood Education Teachers

___________________________________________________________________ Early childhood education (PAUD) is an education at the level prior to the primary education that has a very important role in preparing future generations. One of the activities undertaken in an effort to improve the professionalism of early childhood education teachers is supervized by supervisors and principals. However, the academic supervision approach used currently is not in accordance with the needs of the early childhood education teachers. This study aims to (1) describe and analyze the current supervision model in Semarang Municipality; (2) describe and analyze the hypothetical model of collaborative supervision for PAUD teachers. This study uses a modified vrsion of Borg and Gall’s research and development (R & D) approach. The subjects of this research were PAUD supervisor and principal as well as PAUD teacher in Semarang Municipality. Data were drawn using interview techniques, questionnaires, documentation, and forum group discussions (FGD). The data were analyzed using descriptive analysis technique which included an analysis of the experts and practitioners’ validation sheets. The preliminary study yielded a factual model which shows that the supervision carried out by the PAUD supervisor has not been routine; the supervision program that he/she created is still a combination of kindergarten and elementary school programs; there has been no collaboration between supervisor and teacher; the results of the supervision have not been discussed with the teacher; there has been no follow up to the results of supervision. The conceptual model in this study was designed in accordance with the collaborative academic supervision theory that there is an agreement between supervisor and teacher therough which the supervision stages included planning, implementation, evaluation, and follow up. The results of the model development include the addition of the follow-up stage that includes monitoring the results of the supervision and guidance on a regular basis to improve the professionalism of the PAUD teachers.
Reverse engineering of drug-induced QT(c) interval prolongation: a systems pharmacology approach

QT prolongation and the risk of ventricular arrhythmias in humans remain a major concern during drug development despite the advancement of numerous methodologies to detect the potential for drug-induced changes in cardiac conductivity and the availability of regulatory guidelines for the evaluation of pro-arrhythmic drug effects. Numerous in vitro and in vivo studies are conducted before new molecules are progressed into humans; for many of these compounds extrapolation from non-clinical experimental data suggests no clinically relevant effects. Still a vast number of compounds show pro-arrhythmic signals during clinical development. Current practice and decision making in cardiovascular safety research in R&D relies on the use of independent experimental filters to assess pro-arrhythmic risk: a) ion or hERG-channel specific assays in which binding or inhibition are assessed in vitro , b) functional measures of drug effect on action potential or tissue conductivity, c) heart-rate corrected QT interval (QTc) prolongation in non-clinical species in vivo, and finally d) QT prolongation in humans. In this review we discuss the experimental methods which are used to assess the risk of drug-induced arrhythmias across the various stages of drug development. Quantitative pharmacology concepts are then proposed as the basis for an integrated approach, in which concentration-effect relationships are used to disentangle drug-specific from system-specific properties. In addition, the incorporation and aggregation of historical data provide a strong basis for translation and interpretation of interspecies, as well as in vitro - in vivo , differences. A systems approach based on a generic parameterisation is envisaged in which the risk of QT prolongation in humans is derived as early as possible during drug development.
ANTIOXIDANT AND ANTIDIARRHOEAL ACTIVITY OF Manniophyton africanum LEAF EXTRACT IN MICE

The antidiarrhoeic activity of the methanolic leaf extract of Manniophyton africanum (MEMA) has been evaluated out in mice using different models (Castor oil-induced diarrhoea, effects on gastrointestinal motility, and castor oil-induced gastric enteropooling). MEMA (200,400 and 600 mg/kg, p.o.) inhibited at 5% significance level, the frequency of defecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, markedly inhibited the movement of charcoal meal plug through the gastrointestinal tract, in a dose dependent manner, comparable to diphenoxylate and atropine. It however had no effect in the intra luminal fluid content in the castor oil-induced gastric enteropooling. Diphenoxylate (5 mg/kg) and atropine (3 mg/kg) were used as the reference drugs. MEMA were also found to be possessing marginal (52-66%) free radical scavenging activities in vitro using the DPPH and FRAP models. The remarkable antidiarrhoeal property of MEMA in vivo gives credence to its use in the management of a wide range of diarrhoeal state. The total antioxidant activity of the methanolic leaf extract of Manniophyton africanum was estimated by Ferric Reducing Antioxidant Power (FRAP) assay of Benzie and Strain (1999) and 1,1 –diphenyl-2-picryl-hydrazyl (DPPH) photometric assay of Iwalewa et al . , (2008).
Cross-talk between Aryl Hydrocarbon Receptor and the inflammatory response: a Role for NF- κ B

The Aryl hydrocarbon receptor (AhR) is involved in the regulation of immune responses, T-cell differentiation and immunity. Here we show that inflammatory stimuli such as lipopolysaccharide (LPS) induce the expression of AhR in human dendritic cells (DC) associated with an AhR-dependent increase of Cytochrome P4501A1 (CYP1A1). In vivo data confirmed the elevated expression of AhR by LPS and the LPS-enhanced 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD)-mediated induction of CYP1A1 in thymus of B6 mice. Inhibition of nuclear factor-kappa B (NF-κ B) repressed both normal and LPS-enhanced, TCDD-inducible, AhR-dependent gene expression and canonical pathway control of RelA regulated AhR-responsive gene expression. LPS-mediated induction of AhR was NF- κ B-dependent as shown in mouse embryonic fibroblasts (MEFs) derived from Rel null mice. AhR expression and TCDD-mediated induction of CYP1A1 was significantly reduced in RelA deficient MEF compared to wildtype MEF cells and ectopic expression of RelA restored the expression of AhR and induction of CYP1A1 in MEF R elA null cells. Promoter analysis of the human AhR gene identified three putative NF- κ B-binding elements upstream of the transcription start site. Mutation analysis of the AhR promoter identified one NF-κ B site as responsible for mediating the induction of AhR expression by LPS and electrophoretic shift assays demonstrated that this NF- κ B motif is recognized by RelA/p50 heterodimer. Our results show for the first time that NF- κ B RelA is a critical component regulating the expression of AhR and the induction of AhR-dependent gene expression in immune cells illustrating the interaction of AhR and NF- κ B signaling.
RISK FACTORS OF EXCESSIVE DAYTIME SLEEPINESS AMONG MEDICAL STUDENTS IN SAUDI ARABIA

: Background: Excessive daytime sleepiness is usually attributed to laziness, but it could be a manifestation of a serious medical problem and negatively impact academic achievement. The present study assessed the daytime sleepiness and factors associated with the same among medical students. Methods: This cross-sectional study conducted among medical students in Saudi Arabia during the period from January to October 2018. Two hundred and seventy-seven medical students were invited to sign a written informed consent then responded to a structured questionnaire based on the Epworth Sleepiness Scale, demographic factors, Technology use, Cumulative Academic Grade (GPA), coffee consumption and sleeping pill use. The Chi-square and t-test were used to compare the students with excessive daytime sleepiness and those without the disorder and test the associated factors. Results: They were 277 medical students (men 49.5%), mean age (21.78±1.59) years, excessive daytime sleepiness was evident in 52.3% of students, the average technology use/day was 5.25± 2.84 hours, the coffee intake was 1.98±1.36 cups/day, while 14.3% were using sleeping pills. No significant statistical associations were evident between the daytime sleepiness and age, sex, technology use, sleeping pills, chronic diseases, coffee intake and the GPA,(P-value<0.05). Excessive daytime sleepiness was prevalent among the medical students; no significant differences were detected between the students with this serious sleeping disorder and those without regarding demographic factor, Internet mobile phone texting, sleeping pills use, coffee consumption, and the cumulative grades.
Antibiotic resistance patterns and genetic relatedness of Enterococcus faecalis and E. faecium isolated from military working dogs in Korea

Enterococcus spp. are normally present in the gastrointestinal tracts of animals and humans, but can cause opportunistic infections that can be transmitted to other animals or humans while harboring antibiotic resistance genes. To investigate whether this is a potential risk for handlers of military working dogs (MWDs), we analyzed antibiotic resistance patterns and genetic relatedness of Enterococcus spp. isolated from fecal samples of MWDs of various ages (n = 65). The isolation rate of Enterococcus spp. , and specifically of E. faecalis and E. faecium , was 87.7% (57/65), 59.6% (34/57), and 56.1% (32/57), respectively, as determined by bacterial culture and multiplex PCR. The isolation rate of E. faecalis gradually decreased with age. Rates of resistance to the antibiotics ciprofloxacin, gentamycin, streptomycin, sulfamethoxazole–trimethoprim, imipenem, and kanamycin among Enterococcus spp. increased in adolescents and adults and decreased in senior dogs, with some isolates showing three different antibiotic resistance patterns. We also confirmed transmission of antibiotic resistant strain by pulsed-field gel electrophoresis. These results suggest that antibiotic resistance genes are transmitted among MWDs and that surveillance studies should be periodically carried out to monitor changes in antibiotic resistance that may necessitate modification of antibiotic regimens to manage antibiotic resistance transmission. ABSTRACT IN KOREAN ( 국문초록
Inﬂammation-Like Glial Response in Lead-Exposed Immature Rat Brain

Numerous studies on lead (Pb) neurotoxicity have indicated this metal to be a dangerous toxin, particularly during developmental stages of higher organisms. Astrocytes are responsible for seques-tration of this metal in brain tissue. Activation of astroglia may often lead to loss of the buffering function and contribute to pathological processes. This phenomenon is accompanied by death of neuronal cells and may be connected with inﬂammatory events arising from the production of a wide range of cytokines and chemokines. The effects of prolonged exposure to Pb upon glial activation are examined in immature rats to investigate this potential proinﬂammatory effect. When analyzed at the protein level, glial activation is observed after Pb exposure, as reﬂected by the increased level of glial ﬁbrillary acidic protein and S-100 b proteins in all parts of the brain examined. These changes are associated with elevation of proinﬂammatory cytokines. Production of interleukin (IL)-1 b and tumor necrosis factor- a is observed in hippocampus, and production of IL-6 is seen in forebrain. The expression of fractalkine is observed in both hippocampus and forebrain but inconsiderably in the cerebellum. In parallel with cytokine expression, signs of synaptic damage in hippocampus are seen after Pb exposure, as indicated by decreased levels of the axonal markers synapsin I and synaptophysin. Obtained results indicate chronic glial activation with coexisting inﬂammatory and neurodegenerative features as a new mechanism of Pb neurotoxicity in immature rat brain.
Corneal Astigmatism in cataract surgery candidates

Objetivo: Relatar a prevalência e analisar os padrões de astigmatismo corneano em candidatos à cirurgia de catarata. Métodos: Os pesquisadores examinaram 2136 olhos de 1204 pacientes a cirurgia de catarata de 1 de janeiro a 31 de dezembro de 2016. Todos os candidatos foram avaliados com interferometria de coerência parcial (IOLMaster). Os resultados foram analisados estatisticamente em relação às variáveis qualitativa e quantitativa. Resultados: A média de idade dos pacientes foi de 71,9 anos, com predomínio do sexo feminino. A média de astigmatismo corneano foi de 1,0 dioptria (D). Contra a regra (ATR), o astigmatismo aumentou com a idade. As mulheres apresentaram córneas mais íngremes que os homens. Nos pacientes que tiveram os dois olhos medidos, encontramos fortes correlações entre quantidade de astigmatismo nos olhos direito e esquerdo, eixo e ceratometria. No geral, 39% dos olhos tinham astigmatismo corneano >1,00 D, e 19% > 1,50 D. Conclusões: Uma percentagem significativa da nossa população apresenta astigmatismo corneano >1,00, D com uma mudança de WTR (a favor da regra) para ATR (contra a regra) com o aumento da idade. Purpose: To report the prevalence and analyse corneal astigmatism patterns in cataract surgery candidates. Methods: Researchers examined 2136 eyes from 1204 patients for cataract surgery from 1 January to 31 December 2016. All the candidates were evaluated with partial coherence interferometry (IOLMaster). The results were analysed statistically in relation to qualitative and quantitative variables. Results : The mean age of the patients was 71.9 years with a female predominance. Mean corneal astigmatism was 1.0 dioptre (D). Against the rule (ATR) astigmatism increased with age. Women presented with steeper corneas than men. In those patients who had both eyes measured, we found strong correlations between amount of right and left eye astigmatism, axis and keratometry. Overall, 39% of the eyes had corneal astigmatism > 1.00 D and 19% >1.50 D. Conclusions: A significant percentage of our population presents with corneal astigmatism > 1.00 D with a shift from WTR (with the rule) to ATR with increasing age. Our findings, in a population that has never been described before, will be helpful to surgeons to enhance surgical techniques, patients to improve visual outcomes, IOL (intraocular lens) manufacturers to make better designs and health agents to optimise resources.
A crustal thickness map of Africa derived from a global gravity ﬁeld model using Euler deconvolution

We develop a new continental scale crustal model for Africa by modelling the free-air gravity anomaly EIGEN-GL04C, which was developed from 30 months of GRACE Level 1B data covering the period from 2003 February to 2005 July, and surface gravity data from seven different sources. From this gravity model, crustal thickness is estimated using 3-D Euler deconvolution, a method that does not rely on a priori depth and density constraints. The results are in good agreement (i.e. within 5 km) of seismically determined Moho depth estimates from across the continent, except for narrow tectonic regions, such as rift valleys, and areas where seismic velocity models of the crust indicate a gradational Moho. The results show that crustal thickness is fairly homogeneous, with an average crustal thickness for the whole continent of 39 ± 2( SD ) km. The average Moho depth for most terrains is within 5 km of the continental average, and there is little variability between terrains of different age. The average thickness for Archean, Proterozoic and Palaeozoic crust is 39, 39 and 41 km, respectively. Crustal
Interactive on of middle atmospheric temperature to the solar 27-day an analysis of 13 of

This paper reports on the 27-day (corresponding to one solar rotation) periodicities in temperature data from MLS covering 13 years of data and the vertical range 20-90 km. The authors use the super-epoch approach to identify the 27 day signal. Various sensitivity tests are made to demonstrate the robustness of their results. The scientific methods they use is is very clearly described and their work tracable for the reader. I recommend publication after some minor corrections. My main criticism is that an evaluation of the results obtained here with respect to other similar analyses on temperature data (many cited and summarised in the Introduction) remains somewhat vague. It is important to stress here which results are new (not seen by others) in addition to confirmation of agreement with prior work.