Miracle-dz/UniFAR-FTUs huggingface dataset:
Tracking Pathways of Referrals to Early Intervention

The study described in this paper examined the extent to which contacts with different health-care professionals infl uenced referrals of 16 children with various diagnoses to early intervention. Information was gathered from interviews with the children’s parent(s) and from records maintained as part of each child’s participation in early intervention. Findings showed that for children who were seen by health-care professionals in hospital settings, referrals to early intervention were more likely to be made at the time of a child’s diagnosis or at the time of recognition of a developmental problem. In contrast, the larger the number of contacts with nonhospital health-care providers, the longer it took for a child to become involved in early intervention. Implications for child fi nd are described.
Late Weichselian ice flow evolution in south-central Norway

The exact configuration of the last deglaciation in central parts of Norway has long been debated, partly because dramatic relief in the area caused localized ice flow patterns, which are difficult to correlate with each other. In an attempt to resolve these issues we have employed regional mapping by using satellite images, combined with new as well as previously collected field data. The dataset at hand reveals major ice flow patterns, probably correlated with the onset of the last deglaciation. They emanate from the Jotunheimen mountain areas, trend in a northeasterly direction, and gradually turn northward. We tentatively correlate this ice flow configuration with the deglaciation before the Younger Dryas (YD). Later on, as the deglaciation continues, the general ice flow turns more towards the northwest. It has previously been suggested that this northwestward trending ice movement could be correlated with the late YD "Hoklingen Substage" (c. 10,300-10,400 C years BP). The present reconstruction, by and large supports this correlation.
Preference information incorporation for decision-making in a DEA model using the Choquet integral: Performance assessment of secondary healthcare providers

In a world in permanent (r)evolution that revolves around money, seeking new ways to contain costs, better allocate resources, and, overall, improve performance is a constant across all the fields. Hence, the usage of computational methods based on operational research and statistical science is crucial for achieving an appropriate combination of efficiency and effectiveness, especially in domains where the decision-making process is a complex task. This is where Data Envelopment Analysis (DEA) comes in. However, as a non-parametric and, usually, purely objective technique, DEA makes up for in flexibility and adaptability what it lacks in incorporating preference information, which is particularly important in areas where the judgment of decision-makers is crucial. This work proposes a cutting-edge and original approach to fill in this knowledge gap by linking DEA and multi-criteria decision-making (MCDM) with an additive DEA model that takes into consideration criteria interactivity, by using an inference methodology to determine their weights, and decision-makers’ preference information incorporation, by taking advantage of the Choquet multi-criteria preference aggregation model. Thus, PRICDEA (PReference information Incorporation using the Choquet integral in a DEA model) was born, generating credible weights stemmed from the decision-maker’s judgments, and yielding acceptable and valid results in a tailor-made case study of performance assessment of Portuguese National Healthcare Service secondary healthcare providers across robustness-testing scenarios.
Treatment of multiple myeloma with high-dose chemotherapy and autologoushaematopoietic progenitor cell transplantation - a single centre experience

Introduction . Patients suffering from multiple myeloma treated with melphalan and prednizone survive three years on ave- rage. Recently a higher survival rate has been associated with high-dose chemotherapy followed by transplantation of haema- topoietic progenitor cells. This paper presents our experience with high-dose chemotherapy in the treatment of patients suffe- ring from multiple myeloma. Patients and methods . 31 patients with multiple myeloma were treated with autologous transplantation of progenitor cells from peripheral blood: 24 patients underwent a single transplantation, whereas 7 underwent double transplantation. Du- ring conditioning regimen melphalan was administered for the first transplantation, and melphalan or BEAM regimen for the second one. Results . 29 patients achieved complete haematological recovery, the regeneration of megakaryopoiesis being statistically de- layed after the second transplantation. There were 12 CR, 2 PR and 15 NR. Three year EFS was 31%, OS was 85%. The risk factor for EFS was late versus early transplant, and for OS it was renal failure. Conclusions . Results show that high-dose chemotherapy, followed by autologous transplantation of progenitor cells, is a re- latively low risk procedure (4%). and allows achieving long term remission.
The Crucial Role of CXCL8 and Its Receptors in Colorectal Liver Metastasis

CXCL8 (also known as IL-8) can produce different biological effects by binding to its receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 and its receptors are associated with the development of various tumor types, especially colorectal cancer and its liver metastases. In addition to promoting angiogenesis, proliferation, invasion, migration, and the survival of colorectal cancer (CRC) cells, CXCL8 and its receptors have also been known to induce the epithelial-mesenchymal transition (EMT) of CRC cells, to help them to escape host immunosurveillance as well as to enhance resistance to anoikis, which promotes the formation of circulating tumor cells (CTCs) and their colonization of distant organs. In this paper, we will review the established roles of CXCL8 signaling in CRC and discuss the possible strategies of targeting CXCL8 signaling for overcoming CRC drug resistance and cancer progression, including direct targeting of CXCL8/CXCR1/2 or indirect targeting through the inhibition of CXCL8-CXCR1/2 signaling.
Carvedilol Aggravates Orthostatic Hypotension in a Diabetic Patient with Chronic Renal Failure

A 64-year-old male was admitted because of progressive dyspnea, bipedal edema and reduced urine output. His medical history included coronary artery disease with coronary artery bypass graft, hypertension and type 2 diabetes mellitus with chronic renal failure and retinopathy. During admission, he developed severe postural dizziness. Positional blood pressure and heart rate measurements revealed fluctuations in systolic blood pressure greater than 20 mmHg but no significant heart rate change. Two days after stopping carvedilol, systolic blood pressure declined by only 10 mmHg and heart rate increased significantly with positional changes. Orthostatic hypotension due to autonomic neuropathy was suspected. Nerve conduction velocity study showed severe sensorimotor polyneuropathy. Sympathetic skin response and RR interval variability tests indicated autonomic dysfunction. Combinations of alpha- and beta-blockers should always be administered with caution in diabetics, who are likely to have autonomic nervous system dysfunction and in whom the use of such medications may increase the risk of orthostatic hypotension.
Reply to Comment by D A Guimaraes and J E Tanus-Santos on “Cardiac effects of 6 months’ dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomised-controlled, VASERA TRIAL”

Citation for published version (APA): Faconti, L. , Cruickshank, J. K. , & Webb, A. J. (2019). Reply to 'Comment on 'Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomised controlled VaSera trial' by Faconti et al.'. British Journal of Clinical Pharmacology, 85(5), 1037-1038. https://doi.org/10.1111/bcp.13890
Optimal Dynamic Asset Allocation for DC Plan Accumulation/Decumulation: Ambition-CVAR

Abstract We consider the late accumulation stage, followed by the full decumulation stage, of an investor in a defined contribution (DC) pension plan. The investor’s portfolio consists of a stock index and a bond index. As a measure of risk, we use conditional value at risk (CVAR) at the end of the decumulation stage. This is a measure of the risk of depleting the DC plan, which is primarily driven by sequence of return risk and asset allocation during the decumulation stage. As a measure of reward, we use Ambition, which we define to be the probability that the terminal wealth exceeds a specified level. We develop a method for computing the optimal dynamic asset allocation strategy which generates points on the efficient Ambition-CVAR frontier. By examining the Ambition-CVAR efficient frontier, we can determine points that are Median-CVAR optimal. We carry out numerical tests comparing the Median-CVAR optimal strategy to a benchmark constant proportion strategy. For a fixed median value (from the benchmark strategy) we find that the optimal Median-CVAR control significantly improves the CVAR. In addition, the median allocation to stocks at retirement is considerably smaller than the benchmark allocation to stocks.
Morphometry of cervical vertebrae in tiger (Panthera tigris)

Atlas is the first cervical vertebra and atypical in both structure and function. It articulates with the skull cranially and with the axis caudally. The atlas and axis of tiger (Panthera tigris) are atypical in both structure and function. The spinous process is absent with reduced body parts in atlas. The cylindrical den is present at the cranial extremity and cranial articular areas are convex and triangular in shape in axis. The cervical vertebrae of tiger presented characteristics of typical vertebrae from 3rd cervical to 7th cervical vertebrae. The cranial extremity of the body is slightly convex and the caudal extremity is slightly concave.
Production performance of sheep and certain management practices in farmers’ flocks of South East Rajasthan

Data on growth and wool production traits of Malpura and Kheri sheep maintained under farmers' flocks were recorded during 1994 to 1996 and analyzed for performance evaluation. The overall least squares means for birth, 3, 6, 9 and 12 months in Malpura sheep were 3.16, 9.86, 15.58, 20.23 and 25.56 kg, respectively whereas in Kheri sheep corresponding figures were 3.12, 10.81, 15.97, 19.88 and 23.68 kg. Sheep farmers of this region take three clips from their sheep in a year i.e. February–March, June and September–October months. Overall means for greasy fleece yield (GFY) per clip in Malpura sheep was 515 g and in Kheri sheep it was 510 g. Year had significant effect for all the growth traits. Breed also influenced significantly all the body weights except birth weight. Year and sex had significant effect on wool production. About 92% ewes produced first lamb at 16 to 20 month age (2 teeth stage), which indicated that most of the farmers breed their ewes at yearling stage.
EXAMINING E-VOTING INTENTION IN AN EMERGING NATION: TOWARDS A UNIFIED VIEW

The goal of this research is to examine consumers’ intention to use an e-voting system in an emerging nation by using the Unified Theory of Acceptance and Use of Technology (UTAUT) Model as the guiding principles. Data collected among 300 citizens in an emerging nation were analysed using Partial Least SquareStructural Equation Modelling (PLS-SEM) approach. The present research clearly pointed out that positive performance expectancy, effort expectancy, trust in the Internet, and low computer anxiety will increase consumers’ intention to use an evoting system. Nonetheless, the latter was not impacted by aspects of social influence. Among these constructs, a lower level of computer anxiety was found as the most vital predictor towards consumers’ intention to use an e-voting system in an emerging nation. The reason for this positive connection is that they have a minimal level of wariness that their vote could be lost when hitting the wrong key while casting votes. Further, there is zero expectance of unforeseen mistakes during counting of votes in the paperless voting with no daunting experience. Direction for future research is also elucidated.
RRTM_A_180604 103..108

Rajesh Gupta AK Rawat Poonam Singh Jyoti Gupta Ashish Pathak 1Department of Paediatrics, Government Medical College, Datia, MP, India; 2Department of Paediatrics (Formerly), Bundelkhand Medical College, Sagar, MP, India; 3Department of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India; 4Department of Microbiology, Chirayu Medical College, Bhopal, MP, India; 5Department of Paediatrics, R.D. Gardi Medical College, Ujjain, MP, India; 6Global health (IHCAR)/Department of Public Health Science Karolinska Institutet, Stockholm 171 77, Sweden; 7Department of Women and Children’s Health, IMCH, Uppsala University, Uppsala, Sweden
Why differentiated integration is such a common practice in Europe: A rational explanation

With Brexit imminent, the debate on the need for differentiated integration (DI) by means of opting-out has gained new momentum. At the same time, non-member states decide to adopt European Union (EU) rules as exemplified by the European Neighbourhood Policy. In light of these opposing observations, we examine the EU’s disposition to supply DI. We outline the strategic interactions of the EU member states or non-members in the context of two forms of DI: opting-out and inducing-in. In the case of opting-out, EU member states can refrain from adopting EU rules; inducing-in refers to providing non-member states with incentives to adopt EU rules. We show that the information asymmetries inherent to the strategic interactions result in a situation in which the EU is likely to supply opportunities to opt-out for member states to a much greater extent than necessary. Furthermore, the EU is likely to offer more compensation to non-member states in exchange for adopting EU rules than it would actually need to.
Toward an Effective Family Support System in Japan

Japan has the highest admission rate of patients with schizophrenia in the world, thus emphasizing the need for building relationships between psychiatric hospitals and resources for community living. Confucian ideas and the tradition of providing care to family members are central to cultures and these socio-cultural beliefs regarding family care in East Asian countries may seriously influence the experiences of family caregivers. This article reviews and draws conclusions from three Japanese and Korean studies that found that patients with schizophrenia are likely to isolate themselves from society, thus avoiding contact with nonfamily members and that these behaviors are correlated to a greater caregiver role and an increased caregiver burden. Japanese families of patients with schizophrenia are likely to perceive a stigma from others and are also likely to think that schizophrenia should be hidden from others in the community. Japanese families tend to adopt resignation as a strategy for coping with the strong stigma attached to schizophrenia. Additionally, Japanese families are more resistant to allowing others to care for family members with schizophrenia. Hence, there is a close tie between schizophrenia patients and their families. These findings suggest that Japanese mental health strategies should favor providing effective support for reducing caregiver burden and eliminating reliance on inappropriate coping strategies (i.e., resignation and unwillingness to accept support from outside the family) for family members of schizophrenia patients.
Toxicity Symptoms among Migrant Agropesticide Workers in Oman

The toxicity symptoms among 79migrant pesticide workers involved in open-field pesticide application in Oman were studied. Questionnaires addressing the workers' demographics, pesticide use and practices, use of protective devices, disposal of empty containers, storage of pesticides and self-reported poisoning symptoms were administered face-to-face to the workers before commencement of work, during break or at home. A total of 28 toxicity symptoms were reported, skin rash being the symptom reported by a majority of the workers (78%), followed by increased salivation (68%). The gravity of toxicity symptoms was attributed principally to the non-use of protective devices during pesticide spraying. Other factors contributing to poisoning were the workers' poor post-application sanitation habits, improper disposal of empty pesticide containers and storage of partially used pesticides in bedrooms. In order to reduce the incidents of poisoning among the agropesticide workers, there is a need to educate them about the benefits of using PPE (personal protective equipment) and ensuring that they adopt good hygiene and sanitation habits at all stages of pesticide handling.
Enhancing Students’ Vocabulary Learning and Retention through Drama Activities

This study was conducted with a sample group of 36 non-English major undergraduate students. The experiment was carried out for eight weeks. Data were collected using a vocabulary test administered before and after the implementation of the treatment. The scores the students obtained from the pre-test and the post-test were compared using paired sample t-test and Hedges’ g effect sizes to measure the effects and the magnitudes of the effects caused by drama activities. Five months after the end of the experiment, the vocabulary test was administered again to measure students’ learning retention. Findings revealed that there was a statistically significant difference between the mean scores students obtained from the pre-test and post-test of vocabulary achievement test at a significance level of 0.05. The effect sizes yielded the value of 4.69, which was considered very large. The results of the delayed posttest showed that the students lost 36.90 per cent of their vocabulary knowledge. The data obtained from the students’ self-evaluation checklists and students’ logs indicated that the students had positive attitudes towards drama activities.
COMPARATIVE ECONOMIC STUDY OF ORGANIC AND CONVENTIONAL RICE

This study compares the economics of production between organic and conventional lowland rice farming in Magsaysay, Davao del Sur. The two farming systems were compared in terms of production function and cost and return. An OLS translog production function was estimated for both production systems using SHAZAM Version 9.0. The production functions suggest that organic rice farmers should increase their seeding rate to further increase their production while conventional rice farmers should increase their labor input and pesticide application to increase their output. Yield of conventional rice farms is 23% higher than organic rice farms but its high input costs and lower farm gate price lower the net returns. Though the difference is not significant returns above total costs of organic farming is higher by than conventional rice farming.
Phase I evaluation of the safety of conatumumab (AMG 655) in combination with AMG 479 in patients (pts) with advanced, refractory solid tumors.

3102 Background: Preclinical studies show that evasion of death receptor (DR)-mediated apoptosis may depend on intact growth factor signaling. DR agonists have not previously been combined with IGF-1R inhibitors in published clinical studies. The combination may yield synergistic targeted antitumor activity without added toxicity. This study combined 2 investigational, fully human monoclonal antibodies: conatumumab, a human DR5 agonist; and AMG 479, an IGF-1R antagonist. Methods: Eligible pts had locally advanced or metastatic chemotherapy refractory solid tumors, ECOG PS of 0 or 1, and adequate glycemic control if diabetic. Pts enrolled into 3 sequential dose cohorts and received conatumumab 1, 3, or 15 mg/kg IV and AMG 479 18 mg/kg IV on day 1 of each Q3W cycle. Dose escalation was based on <33% incidence of dose-limiting toxicities (DLT) during the first cycle. Study endpoints included: dose determination, adverse event (AE) incidence, DLT, anti-drug antibodies, and pharmacokinetics (PK) of both drugs.
A Study on Tensor and Matrix Models for Super-Resolution Fluorescence Microscopy

Super-resolution techniques for fluorescence microscopy are invaluable tools for studying phenomena that take place at sub-cellular scales, thanks to their capability of overcoming light diffraction. Yet, achieving sufficient temporal resolution for imaging live-cell processes remains a challenging problem. Exploiting the temporal fluctuations (blinking) of fluo-rophores is a promising approach that allows employing standard equipment and harmless excitation levels. In this work, we study a novel constrained tensor modeling approach that takes this temporal diversity into account to estimate the spatial distribution of fluorophores and their overall intensities. We compare this approach with an also novel matrix-based formulation which promotes structured sparsity via a continuous approximation of the cardinality function, as well as with other state-of-the-art methods.
Bacteriological profile of neonatal septicemia and antibiotic susceptibility pattern of the isolates in western civil hospital India

Background: The objective of this study was to isolate pathogenic bacteria in neo-natal septicemia cases, and to know their antibiotic profile. Material and Method: Under aseptic precautions, blood was drawn from 147 neonates with suspected septicemia and inoculated in BD BACTEC bottle. Isolates obtained were identified as per standard protocol and antibiotic susceptibility was done by Kirby Bauer disc diffusion method (as per CLSI guide-lines). Results: Total number of 90 (61.2%) patients had positive blood cultures. The most common pathogens isolated were Klebsiella pneumoniae (n=49, 54.4%) followed by coagulase negative staphylococcus (CONS, n=21,23.3%) Staphylococcus aureus (n=10, 11%), Escherichia coli (n=5, 5.5%), and Pseudomonas aeruginosa (n=1%). The Gram negative organisms showed high resistance to commonly used antibiotics and were highly sensitive to Meropenem. The Gram positive bacteria showed high resistance to Ampicillin, Erythromycin and Amoxicillin; but they were highly susceptible to Linezolid and Vancomycin. Conclusion: As the Gram negative organisms were the most common isolates in neonatal septicemia, their resistance pattern should be considered essential for deciding the empirical treatment. Prompt treatment of neonatal sepsis with judicious use of appropriate antibiotics can minimize the morbidity and mortality, besides reducing the emergence of multi-drug resistant organisms in ICU’s. Keywords: Sepsis, Klebsiella, Blood Culture, Antibiotics