Miracle-dz/UniFAR-FTUs huggingface dataset:
Title: PROTEIN L- ISOASPARTYL METHYLTRANSFERASE2 Gene Is Differentially Expressed in Chickpea and Enhances Seed Vigor and Longevity by Reducing Abnormal Isoaspartyl Accumulation Predominantly in Seed Nuclear Proteins. Authors: Name:

PROTEIN L-ISOASPARTYL METHYLTRANSFERASE (PIMT) is a widely distributed protein repairing enzyme which catalyzes the conversion of abnormal Lisoaspartyl residues in spontaneously damaged proteins to normal aspartyl residues. This enzyme is encoded by two divergent genes (PIMT1 & PIMT2) in plants unlike many other organisms. While the biological role of PIMT1 has been elucidated, the role and significance of the PIMT2 gene in plants is not well defined. Here, we have isolated PIMT2 gene (CaPIMT2) from chickpea (Cicer arietinum) which exhibits significant increase in isoaspartate residues in seed proteins coupled with reduced germination vigor under artificial aging condition. The CaPIMT2 gene is found to be highly divergent and encodes two possible isoforms (CaPIMT2 and CaPIMT2') differing by two amino acids in region-I catalytic domain through alternative splicing. Unlike CaPIMT1, both isoforms possess a unique 56 amino acid long N-terminus and exhibit similar yet distinct enzymatic properties. Expression analysis revealed that CaPIMT2 is differentially regulated by stresses and ABA. Confocal visualization of stably expressed GFP fused PIMT proteins and cell fractionation-immunoblot analysis revealed that apart from plasma membrane, both CaPIMT2 isoforms localize predominantly in nucleus while CaPIMT1 localizes in cytosol. Remarkably, CaPIMT2 enhances seed vigor and longevity by repairing abnormal isoaspartyl residues predominantly in nuclear proteins upon seed specific expression in Arabidopsis thaliana while CaPIMT1 enhances seed vigor and longevity by repairing such abnormal proteins mainly in the cytosolic fraction. Together, our data suggests that CaPIMT2 has most likely evolved through gene duplication, followed by subfunctionalization to specialize in repairing nuclear proteome. www.plantphysiol. org on August 22, 2017 Published by Downloaded from Copyright © 2013 American Society of Plant Biologists. All rights reserved.
Fluid-structure interaction during the water impact at high horizontal velocity of a thick plate: experimental data and simplified modelling

The elastic deformations of a flat rectangular plate generated during the water entry at high horizontal velocity are investigated both experimentally and theoretically by using a simplified model to derive the out-of-plane displacement as well as the strain everywhere on the plate. Tests were performed on an aluminum plate thick enough to ensure that the deformation was always within the elastic regime. Measurements are provided in terms of pressures, strains and total hydrodynamic loads. The simplified model is a combination of a fluid-loading model, providing the pressure distribution at any time, and a structural model, similar to that proposed in Szilard (2004) and used also in Faltinsen (1999). The model is validated and tuned in one test condition before applying it to the analysis of other test cases. It is found that, although rather simple, it provides very accurate estimates of the strains, aside from some limits occurring at the sides due to the difficulty in correctly representing the boundary conditions.
Survey of Hearth Products in U.S. Homes

Author(s): Siap, D; Willem, H; Price, S; Yang, H; Lekov, A | Abstract: There are over 7 million gas-fired fireplaces currently installed in US households. On an annual basis, these use substantial energy. However, the details of the fireplace energy use and the factors that influence it are currently not well understood. Fireplaces are a type of hearth product, which is a product category that primarily consists of fireplaces, stoves, and gas log sets. For the purpose of this study, the fuels used in hearth products are primarily natural gas, propane, or electricity. They may be vented or unvented. This study reports the results of a web survey of 2,100 respondents in the United States performed in February 2016. The responses were cleaned and weighted using the raking method to form a nationally representative population. The reported data include hearth product characteristics, usage information, and repair and maintenance practices. The hearth product characteristics include the hearth product type, fuel type, ignition system type, features, venting, and installation details. The usage information includes seasonal usage of the main burner and standing pilot (if present), daily usage, and the primary utility (whether decorative or for heating). These raw data are further processed and combined with values from the literature to estimate the annual operating hours and energy use and to assess how these are impacted by the hearth product type, features, age, and the main heating appliance, if present. Based on the survey responses, the estimated average annual hours of usage was 234 for the main burner, and 4,593 for the standing pilot. The results presented provide the most comprehensive data regarding hearth products in the United States published to date. These new data allow for an improved understanding of hearth products’ energy use, which in turn may facilitate the development of more informed analyses, and ultimately more efficient hearth products and reduced energy use. These new data also provide insight into topics not previously studied, such as the effect of hearth product features on energy use.
Third-order safe consensus of heterogeneous vehicular platoons with MPF network topology: Constant time headway strategy

In this paper the problem of centralized control of a platoon of non-identical vehicles under constant time headway strategy (CTHS) is investigated for multi predecessors following (MPF) topology. A centralized neighbor based linear control law using relative position and velocity is considered for each vehicle. Due to communication and parasitic delays and time-varying network topology, the closed-loop dynamics of platoon is in the form of a multiple delayed switched linear system. New approaches are developed to perform the internal stability analysis of one-dimensional heterogeneous vehicular platoons. Afterwards, sufficient conditions assuring the string stability of a platoon under MPF topology are obtained by presenting a new theorem. In continuance of the paper, some conditions on control parameters guaranteeing safety of the platoon in an emergency braking maneuver are presented through a new theorem. Several simulation results are provided to show the effectiveness of the proposed methods.
Comparison of Contemporary Treatment Options for Early Prostate Cancer: A Single Institution Series

Purpose: To evaluate outcomes of low-risk prostate cancer patients managed with competing treatments, in a single institution. Methods: Patients with low-risk cancer (cT1-T2a and Gleason score 6 and PSA<10ng/ml) from 2006-2008 were included. Treatment details and worst late toxicities (Common Terminology Criteria for Adverse Events version 3.0) were retrieved through retrospective chart review. Biochemical relapse-free survival following primary (pbRFS) and salvage treatments (sbRFS), metastasis-free (MFS), cause-specific (CSS) and overall survival (OS) were also evaluated. Results: In 582 patients, treatment options were active surveillance (AS, N=181), radical prostatectomy (RP, N=59), external beam radiation (EBRT, N=66; 76 Gy in 38 fractions), low-dose rate brachytherapy (LDR, N=192), stereotactic ablative radiotherapy (SABR, N=84; 35Gy in 5, weekly fractions). Median follow-up was 72.8 months. Six-year pbRFS and sbRFS were 94.0% and 95.8%, 84.1% and 98.3%, 92.1% and not applicable, 94.4% and not applicable, 95.8% and 98.7%; for AS, RP, EBRT, LDR and SABR, respectively. In multivariate analysis, RP had inferior pbRFS compared to EBRT, LDR or SABR (p-value <0.05) and a trend for AS (p-value 0.15). CSS, MFS and OS were similar. Toxicities were minimal in AS cohort. EBRT patients had higher rates of dysuria (19.7%), transurethral resection of prostate (6.1%) and hematochezia (7.6%). One patient each in EBRT, LDR and SABR cohorts had grade 4 toxicity. Toxicity data was not available for RP. Conclusion: In primary setting all treatment modalities apart from RP had a 6-year pbRFS >90%, likely due to selection bias. Following salvage therapy, sbRFS was >95.0% in AS, RP and SABR cohorts.
Practice of Epidemiology Assessment of the “Case-Chaos”Design as anAdjunct to theCase-Control Design

In 2012, a novel case series method dubbed the “case-chaos” design was proposed as an alternative to casecontrol studies, whereby controls are artificially created by permutating the exposure information of the cases. Our aim in the current work was to further evaluate the case-chaosmethod. Using a theoretical example of 2 risk factors, we demonstrated that the case-chaos design yields risk estimations for which the odds ratios obtained for every risk factor are in the same ascending order as the risk factors’ exposure prevalences in the case group. Applying the method to data from the European Study of Severe Cutaneous Adverse Reactions (EuroSCAR; 1997–2001), we were not able to obtain sensible results but instead produced results as predicted by our theoretical assessment. We therefore claim that the method is equivalent to declaring risk solely on the basis of prevalences obtained in cases. While the proposers of the case-chaos method view it as a useful adjunct, we show that it cannot produce sensible estimates.
HIGHLIGHTED TOPIC Upper Airway Control and Function: Implications for Sleep-Disordered Breathing Tetraplegia is a risk factor for central sleep apnea

Sankari A, Bascom AT, Chowdhuri S, Badr MS. Tetraplegia is a risk factor for central sleep apnea. J Appl Physiol 116: 345–353, 2014. First published October 10, 2013; doi:10.1152/japplphysiol.00731.2013. —Sleepdisordered breathing (SDB) is highly prevalent in patients with spinal cord injury (SCI); the exact mechanism(s) or the predictors of disease are unknown. We hypothesized that patients with cervical SCI (C-SCI) are more susceptible to central apnea than patients with thoracic SCI (T-SCI) or able-bodied controls. Sixteen patients with chronic SCI, level T6 or above (8 C-SCI, 8 T-SCI; age 42.5 15.5 years; body mass index 25.9 4.9 kg/m) and 16 matched controls were studied. The hypocapnic apneic threshold and CO2 reserve were determined using noninvasive ventilation. For participants with spontaneous central apnea, CO2 was administered until central apnea was abolished, and CO2 reserve was measured as the difference in end-tidal CO2 (PETCO2) before and after. Steady-state plant gain (PG) was calculated from PETCO2 and VE ratio during stable sleep. Controller gain (CG) was defined as the ratio of change in VE between control and hypopnea or apnea to the PETCO2. Central SDB was more common in C-SCI than T-SCI (63% vs. 13%, respectively; P 0.05). Mean CO2 reserve for all participants was narrower in C-SCI than in T-SCI or control group ( 0.4 2.9 vs. 2.9 3.3 vs. 3.0 1.2 l·min ·mmHg , respectively; P 0.05). PG was higher in C-SCI than in T-SCI or control groups (10.5 2.4 vs. 5.9 2.4 vs. 6.3 1.6 mmHg·l ·min , respectively; P 0.05) and CG was not significantly different. The CO2 reserve was an independent predictor of apnea-hypopnea index. In conclusion, C-SCI had higher rates of central SDB, indicating that tetraplegia is a risk factor for central sleep apnea. Sleep-related hypoventilation may play a significant role in the mechanism of SDB in higher SCI levels.
Significance of Shafting Length: A Suezmax Tanker Design Problem

In this paper the influence of shafting length on torsional vibration behavior of suezmax tanker propulsion system is investigated and discussed. Besides, some countermeasures to harmful vibration stresses are also addressed. Finally, an example of suezmax tanker shafting design is given. The initial propulsion plant design, characterized with excessive vibration stresses is improved to satisfy the classification society stress limits and to save relatively short engine room length of 23 meters. For the sake of comparison, the two competitor’s designs require the engine room lengths of more than 25 and 27 meters, respectively.
U . K . Interference by Luteal-Phase Progesterone In a CommercialKit for Measurement of ha-Hydroxyprogesterone

between CA-19-9 concentrations in blood and whether or not patients were taking supplements. Thus, cystic fibrosis is one of the first benign diseases shown to be associated with high CA-19-9 concentrations in blood. The origin of CA-19-9 in these patients instill unknown. it is unlikely to be derived from the pancreas because patients with pancreatitis reportedly have low concentrations of this antigen in their serum (2,3). It may, however, be a specific mucin produced by cystic fibrosis patients. If so, a study on its mechanism of production might provide an insight into the etiology of cystic fibrosis. Finally, measurement of CA-19-9 in blood could be an adjuvant diagnostic aid in cystic fibrosis.
Reconstructing Gravitational Waves from Core-Collapse Supernovae in Advanced LIGO-Virgo

Our current understanding of the core-collapse supernova (CCSN) explosion mechanism is incomplete, with multiple viable models for how the initial shock wave might be energized enough to lead to a successful explosion. Detection of a gravitational wave (GW) signal emitted in the initial few seconds after stellar corecollapse would provide unique and crucial insight into this process. With the Advanced LIGO and Advanced Virgo detectors expected to soon approach their design sensitivity, we could potentially detect this GW emission from a supernova within our galaxy. In anticipation of such a scenario, we study how well the BayesWave algorithm can recover the GW signal from CCSN models in simulated advanced detector noise, and optimize its ability to accurately reconstruct the signal waveforms. We find that BayesWave can confidently reconstruct the signal from a range of supernova explosion models in Advanced LIGO-Virgo for network signal-to-noise ratios & 30, reaching maximum reconstruction accuracies of ∼ 90% at SNR ∼ 100. For low SNR signals that are not confidently recovered, our optimization efforts result in gains in reconstruction accuracy of up to 20-40%, with typical gains of ∼ 10%.
Circulating Level of Serum Chemerin and CRP in Type 2 Diabetes Mellitus Patients with and Without Hypertension in Menopauses Women

Chemerin may play a role in connecting inflammation and metabolic syndrome(MS), C-reactive protein(CRP) level is markedly rising during infectious and inflammatory diseases . The aimed of this study to evaluate both Creactive protein (CRP) and Chemerin as subclinical markers in diabetic patients women. A total of 90 women, including, 24 healthy women (as control group), 66 women patients with diabetes mellitus type 2 (T2DM) (22diabetics with hypertension, 22 diabetics without hypertension and 22 hypertension only),there ages ranged between49-64 years. The result showed that significant increase (p≤0.05) in mean chemerin level in the diabetes group (8.766 ±0.648 ng/ml) in comparison with control group( 4.042±0.320 ng/ml). Also, the result, revealed that significant increase (P<0.05) in the level of chemerin in women suffering from hypertension and diabetes (14.108 ± 0.577 ng/ml) in comparison to the women suffering from diabetic only which reached (8.766 ± 0.648 ng/ml). The data pointed out that the serum CRP level significant increase in T2DM group (6.176±0.1905) compared with control group (2.20±0.15 ng/ml) . Also, the result revealed that significant increase (P<0.05) of the CRP level with hypertension women patients (4.45 ± 0.131ng/ml) compared with the control group( 2.20±0.15 ng/ml) and significant increase(P<0.05) in diabetic with hypertension women group patients comparison with the women suffering from diabetic only. The chemerin and C-RP in hypertensive and normotensive patients with T2DM may be play an important role in activation of Immune Response in these patients .
A Novel Sphingosine 1-Phosphate Receptor Agonist, KRP-203, Regulates Chronic Colitis in IL-10 gene-deficient Mice

Department of Surgery (E1) (J.S., C.M, Y.K., T.N., K.N., Y.S., T.I.) and Department of Complementary and Alternative Medicine (T.I.), Osaka University Graduate School of Medicine, Osaka, Japan Department of Surgery (T.M.), Rinku General Medical Center, Osaka, Japan Discovery Research Laboratories (M.K., T.Y.), Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan JPET Fast Forward. Published on September 26, 2007 as DOI:10.1124/jpet.106. 119172
OP-ICVA200284 1..9

OBJECTIVES: Our goal was to compare the haemodynamic effects of different mechanical left ventricular (LV) unloading strategies and clinical outcomes in patients with refractory cardiogenic shock supported with venoarterial extracorporeal membrane oxygenation (VAECMO). METHODS: A total of 448 patients supported with VA-ECMO for refractory cardiogenic shock between 1 March 2015 and 31 January 2020 were included and analysed in a single-centre, retrospective case–control study. Fifty-three patients (11.8%) on VA-ECMO required LV unloading. Percutaneous balloon atrial septostomy (PBAS), intra-aortic balloon pump (IABP) and transapical LV vent (TALVV) strategies were compared with regards to the composite rate of death, procedure-related complications and neurological complications. The secondary outcomes were reduced pulmonary capillary wedge pressure, pulmonary artery pressure, central venous pressure, left atrial diameter and resolution of pulmonary oedema on a chest X-ray within 48 h. EX TR A C O R P O R EA L TE C H N O LO G IE S VC The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. Interactive CardioVascular and Thoracic Surgery (2020) 1–9 ORIGINAL ARTICLE doi:10.1093/icvts/ivaa284 D ow naded rom http/academ ic.p.com /icvts/advance-art.1093/icvts/ivaa284/6010521 by gest on 03 D ecem er 2020 RESULTS: No death related to the LV unloading procedure was detected. Reduction in pulmonary capillary wedge pressure was highest with the TALVV technique (17.2 ± 2.1 mmHg; P < 0.001) and was higher in the PBAS than in the IABP group; the difference was significant (9.6 ± 2.5 and 3.9 ± 1.3, respectively; P = 0.001). Reduction in central venous pressure with TALVV was highest with the other procedures (7.4 ± 1.1 mmHg; P < 0.001). However, procedure-related complications were significantly higher with TALVV compared to the PBAS and IABP groups (50% vs 17.6% and 10%, respectively; P = 0.015). We observed no significant differences in mortality or neurological complications between the groups. CONCLUSIONS: Our results suggest that TALVV was the most effective method for LV unloading compared with PBAS and IABP for VAECMO support but was associated with complications. Efficient LV unloading may not improve survival.
NDT_A_290494 379..388

1Department of Pediatrics, Skaraborg Hospital, Skövde, Sweden; 2Division of Pediatrics, Department of Biomedical and Clinical Sciences (BKV), Medical Faculty, Linköping University, Linköping, Sweden; 3Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden Introduction: Hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS) are both characterized by generalized hypermobility, in combination with pain, affected proprioception, and pronounced fatigue. Clinical observation indicates that behavioral problems, hyperactivity, and autistic traits are overrepresented in children with those conditions. The purpose of this retrospective study was to establish the prevalence of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) among children with HSD and hEDS treated in our clinic since 2012. Subjects and Methods: Since Ehlers-Danlos syndrome (EDS) diagnostic criteria and international classification were changed in 2017, we equate the older diagnosis EDS hypermobility type with the newer hEDS and the older hypermobility syndrome with HSD. A registry search from the computerized medical record system found 201 children (88 boys, 113 girls) aged 6–18 years who were treated at our pediatrics department with the diagnoses HSD or EDS. All medical records (113 with HSD, 88 with EDS) were reviewed, and key symptoms such as fatigue and pain, as well as diagnosis of ADHD/ASD, were recorded. Results: All EDS cases could be classified as hEDS. Of the entire study cohort, 16% had a verified ADHD diagnosis and a further 7% were undergoing ADHD diagnostic investigation. Significantly more children with hEDS had ADHD compared to children with HSD (p=0.02). In the age group 15–16 years, 35% of those with hEDS had ADHD and, among those aged 17–18 years, ADHD was present in 46%. Children with coexisting ADHD showed a significantly higher proportion of associated symptoms such as fatigue, sleepproblems, and urinary tract problems. ASD had been verified in 6% of the children. Of those with ASD, 92% had sleep problems. Conclusion: This study shows a strong association between HSD or hEDS and ADHD or ASD. Therefore, children with HSD or hEDS may need to be routinely screened for neuropsychiatric symptoms.
Overview of the TREC 2004 Robust Retrieval Track

The robust retrieval track explores methods for improving the consistency of retrieval technology by focusing on poorly performing topics. The retrieval task in the track is a traditional ad hoc retrieval task where the evaluation methodology emphasizes a system’s least effective topics. The most promising approach to improving poorly performing topics is exploiting text collections other than the target collection such as the web. The 2004 edition of the track used 250 topics and required systems to rank the topics by predicted difﬁculty. The 250 topics within the test set allowed the stability of evaluation measures that emphasize poorly performing topics to be investigated. A new measure, a variant of the traditional MAP measure that uses a geometric mean rather than an arithmetic mean to average individual topic results, shows promise of giving appropriate emphasis to poorly performing topics while being more stable at equal topic set sizes.
RESPONSE OF POTATO PLANTS GROWN IN CLAY SOIL TO ANHYDROUS AMMONIA RATES AND FOLIAR APPLICATION OF ZN AND MN

Two Field experiments on potato (Solanum tuberosum, L. cv. Diamont) crop were carried out at El-Qanater Horticultural Research Station, Kalubiya, Governorate, Egypt located at lat. 30.11, long 31.60 and 14.00 m above the mean sea level during two successive seasons 2010 and 2011. The study concerned the use of different rates of anhydrous ammonia (100 and 120 kg N/fed.) with foliar application of zinc and manganese or both on potato crop in alluvial soil. Generally, in most cases, The high anhydrous ammonia level (120 kg N/ fed.) was increased significantly dry matter of potato plant at 90 days from planting and nitrogen & phosphorus content as well as dry weight of tuber/ plant (g/plant), fresh & dry tuber yield/fed. , N, P, K, Zn and Mn contents of tuber compared to low anhydrous ammonia level (100 kg N/ fed.) of both seasons. Generally, the most parameters in this investigation were increased significantly when the treatment of foliar application with mixture of Zn and Mn was carried out in both seasons. In contrast, the lowest ones were recorded by the control treatment (without foliar spray) followed by sole foliar spray with Zn or Mn in two seasons. Finally, the best significant values of most parameters were obtained by interaction between foliar application with mixture of Zn and Mn under the high anhydrous ammonia level (120 kg N/ fed.). Meanwhile, the lowest ones were observed when control treatment (without foliar spray) with the low anhydrous ammonia level (100 kg N/ fed.) was practiced of both seasons.