Miracle-dz/UniFAR-FTUs huggingface dataset:
Retailer’s sourcing strategy under consumer stockpiling in anticipation of supply disruptions

We study a retailer’s sourcing strategy under consumers’ stockpiling behaviour and the factors associated with the selection of an optimal strategy in multi-tier supply chains in the presence of supply disruption risk. Stockpiling behaviour occurs when consumers attempt to mitigate the negative impact of a supply shortage. We prove that those behaviours become stronger if consumers have experienced similar problems before and weaker as more inventories are hoarded. Based on these findings, numerical analysis is carried out to compare the superiority of single sourcing versus dual sourcing from retailer’s perspective. Our results suggest that the superiority is highly dependent on factors such as supplier’s volume flexibility, retailer’s purchasing price, and supplier reliability.
Effect of incorporation of graphite nanoparticles on wear characteristics of Mg-WC nano-composites in dry sliding condition

ABSTRACT The current work scrutinises the effect of incorporating WC and graphite (Gr) nanoparticles on the tribological characteristics of Mg-based hybrid nano-composites for different wt. % of WC and Gr. Hybrid nano-composites were synthesised using ultrasonic vibration associated with the stir casting technique. Synthesised nano-composites were characterised in detail using optical microscopy (OM), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). Characterisation confirms superior microstructural integrity compared to the base alloy Mg AZ31 and also confirms particle inclusion. Microhardness values of as-cast hybrid nano-composites were also observed. The addition of 1 wt. % of Gr nanoparticles enhances the microhardness of Mg-1WC and Mg-2WC nano-composites. A pin-on-disk tribotester was used to carry out the tribological tests, using various loads (10 N–40 N) and sliding speeds (0.1 m s−1–0.4 m s−1). Mg-WC nano-composites with 1 wt. % of nano-Gr show better results than those with 2 wt. % of nano-Gr. The coefficient of friction (COF) of Mg-2WC-1Gr is the lowest, followed by Mg-1WC-1Gr, Mg-1WC-2Gr and Mg-2WC-2Gr. Roughness values of worn surfaces were also examined. The worn surface of the Mg-2WC-1Gr sample shows minimum roughness. Worn surfaces were also examined under SEM to reveal wear mechanisms. Abrasion is the most dominant for hybrid nano-composites with 1 wt. % of Gr, while delamination is the most dominant for those with 2 wt. % of Gr.
Radiobiological Comparison of Acuros External Beam and Anisotropic Analytical Algorithm on Esophageal Carcinoma Radiotherapy Treatment Plans

Objective The present study aimed to investigate the dose differences and radiobiological assessment between Anisotropic Analytical Algorithm (AAA) and Acuros External Beam (AXB) with its 2 calculation models, namely, dose-to-water (AXB-Dw) and dose-to-medium (AXB-Dm), on esophageal carcinoma radiotherapy treatment plans. Materials and methods The AXB-Dw and AXB-Dm plans were generated by recalculating the initial 66 AAA plans using the AXB algorithm with the same monitor units and beam parameters as those in the original plan. The dosimetric and radiobiological assessment parameters were calculated for the planning target volume (PTV) and organs at risk (OARs). The gamma agreement for the PTV and the correlation between it and the volume of the air cavity and bone among the different algorithms were compared simultaneously. The dose discrepancy between the theoretical calculation and treatment planning system (TPS) when switching from AXB-Dm to AXB-Dw was analyzed according to the composition of the structures. Results The PTV dose of AXB-Dm plans was significantly smaller than that of the AAA and AXB-Dw plans (P < .05), except for D2. The difference values for AAA vs AXB-Dm (∆Dx,(AAA-AXB,Dm)) and AXB-Dw vs AXB-Dm (∆Dx,(AXB,Dw-AXB,Dm)) were 1.94% [1.27%, 2.64%] and 1.95% [1.56%, 2.27%], respectively. For the spinal cord and heart, there were obvious differences between the AAA vs AXB-Dm (spinal cord: 1.15%, heart: 2.89%) and AXB-Dw vs AXB-Dm (spinal cord: 1.88%, heart: 3.25%) plans. For the lung, the differences between AAA vs AXB-Dm and AAA vs AXB-Dw were significantly larger than those of AXB-Dm vs AXB-Dw. Compared to the case of AAA and AXB-Dw, the decrease in biologically effective dose (BED10, α β = 10 ) of AXB-Dm due to dose non-uniformity exceeded 6.5%, even for a small σ . The average values of equivalent uniform dose in the AAA, AXB-Dw, and AXB-Dm plans were 52.03±. 39 Gy, 52.24 ± . 81 Gy, and 51.13 ± . 47 Gy, respectively. The tumor control probability (TCP) results for PTV in the AAA, AXB-Dw, and AXB-Dm plans were 62.29 ± 1.57%, 62.82 ± 1.69%, and 58.68±1.88%, respectively. With the 2%/2 mm and 3%/3 mm acceptance criteria, the mean values of Δ γ AAA AXB − Dw , Δ γ AAA AXB − Dm , and Δ γ AXB − Dm AXB − Dw were 87.24, 63.3, and 64.81% vs 97.86, 91.77, and 89.25%, respectively. The dose discrepancy between the theoretical calculation and TPS when switching from AXB-Dm to AXB-Dw was approximately 1.63%. Conclusions The AAA and AXB-Dw algorithms overestimated the radiobiological parameters when the tumor particularly consisted of nonuniform tissues. A relatively small dose difference could cause a significant reduction in the corresponding TCP. Dose distribution algorithms should be carefully chosen by physicists and oncologists to improve tumor control, as well as to optimize OARs protection.
PROPIEDADES ELECTRÓNICAS, ESTRUCTURALES Y FERROELÉCTRICAS DE LA DOBLE PEROVSKITA Ba2ZrTiO6

We report the synthesis, the structural characterization, the ferroelectric behavior and the electronic properties of complex perovskite Ba2ZrTiO6. Samples of Ba2ZrTiO6 were synthesized through the standard solid state reaction method. The crystalline structure was studied by means of X-ray diffraction experiments and Rietveld-like analysis. Results reveal that the material crystallizes in a rhomboidal structure, space group R-3 (#148), with cell parameter a=5.8038(7) A. The ferroelectric response of material was established from curves of polarization as a function of applied electric field. Our results reveal that the double perovskite Ba2ZrTiO6 has a ferroelectric hysteretic behavior at room temperature. The studies of the electronic structure show that Ba2ZrTiO6 behaves as a nonmetallic material with gap energy 2.32 eV. The structural parameters obtained from energy minimization, through the Murnaghan equation state are 99.5% in agreement with the experimental data.
Childhood B-Cell Preleukemia Mouse Modeling

Leukemia is the most usual childhood cancer, and B-cell acute lymphoblastic leukemia (B-ALL) is its most common presentation. It has been proposed that pediatric leukemogenesis occurs through a “multi-step” or “multi-hit” mechanism that includes both in utero and postnatal steps. Many childhood leukemia-initiating events, such as chromosomal translocations, originate in utero, and studies so far suggest that these “first-hits” occur at a far higher frequency than the incidence of childhood leukemia itself. The reason why only a small percentage of the children born with such preleukemic “hits” will develop full-blown leukemia is still a mystery. In order to better understand childhood leukemia, mouse modeling is essential, but only if the multistage process of leukemia can be recapitulated in the model. Therefore, mouse models naturally reproducing the “multi-step” process of childhood B-ALL will be essential to identify environmental or other factors that are directly linked to increased risk of disease.
Selected Techniques for Physiotherapy in Dogs

Simple Summary Animal physiotherapy is widely addressed in many scientific reports. Although the effectiveness of physiotherapy has been repeatedly proven in both human and animal models, a small percentage of animal keepers decide to implement physiotherapy as part of treatment programs for their pets. After horses, dogs are the second group of animals that are most frequently subjected to physiotherapy treatments. The present study compiles the current knowledge of canine physiotherapy methods. An attempt was made to systematize this knowledge through selection and description of the most important aspects of canine physiotherapy. Most of the physiotherapeutic methods have been transferred from human treatment protocols. A key issue in the achievement of therapy success is the proper selection of physiotherapeutic procedures and close cooperation between the veterinarian and the physiotherapist. Abstract Physiotherapy is a new dynamically developing field of science in which the original idea was to improve the care for convalescent patients. Its positive effects observed in humans suggested the need for the adaptation and implementation of human physiotherapy techniques in animal care. Dogs are the second group of animals that undergo physiotherapy most frequently. These animals are diagnosed with a number of locomotor system problems, which may be congenital and are often related to the breed or acquired. The aim of the study was to collect and systematize knowledge of animal physiotherapy with emphasis on the selection and description of the most important aspects of canine physiotherapy. The review material consisted of 59 publications, with 230 selected for the review. Physiotherapeutic treatments are applied not only for rehabilitation of animals but also in healthy animals to upgrade their sports performance and improve their welfare. A majority of physiotherapeutic approaches have been transferred from human protocols. A key issue in the achievement of therapy success is the proper selection of physiotherapeutic procedures and close cooperation between the veterinarian and the physiotherapist.
The leaching of trifloxysulfuron-sodium and pyrithiobac-sodium in soil columns as a function of soil liming - doi: 10.4025/actasciagron.v35i2.16349

Normal 0 21 false false false MicrosoftInternetExplorer4 Scarce research has been published concerning the effect of soil pH on the leaching potential of herbicides in tropical soils. Thus, we designed this study to evaluate the influence of soil liming on the leaching of trifloxysulfuron-sodium and pyrithiobac-sodium after simulated rainfall depths in soil columns. In the study, two trials were conducted simultaneously; the first experiment evaluated trifloxysulfuron-sodium (7.5 g ha -1 ), while the second experiment evaluated pyrithiobac-sodium (70 g ha -1 ). Both experiments were conducted in a randomized block design with a 2 x 4 x 5 factorial scheme and four replications. The design’s factors corresponded to 2 soil liming conditions (with or without liming), 4 simulated rainfall depths (0, 15, 30, and 45 mm) and 5 depths in the soil column (0-5, 5-10, 10-15, 15-20, and 20-25 cm). The trials were repeated, and only the source for the soil neutralization was changed, i.e., dolomitic limestone in Experiment 1 and calcium oxide in Experiment 2. Compared to trifloxysulfuron-sodium, the herbicide pyrithiobac-sodium indicated a greater potential for leaching. With more acidic soils, the leaching potential in limed soils was greater for both herbicides. Only the liming that used calcium oxide provided a significant leaching of trifloxysulfuron-sodium for depths greater than 20 cm. Simulated rainfall ≥ 15 mm provided leaching of pyrithiobac-sodium to a depth of 25 cm at near-neutral soil pH values.
Impact of Heavy Metals in Eggs and Tissues of C. caretta along the Sicilian Coast (Mediterranean Sea)

In this study we compared the heavy metal concentration found in different tissues and eggs of the loggerhead sea turtle and evaluated the potential ecotoxicological risk for this important species. Eighteen heavy metal elements were determined in different tissues (liver, gonads, fat, kidney, heart, brain, and spleen) of nine individuals of Caretta caretta found stranded along the coasts of Messina (Sicily, Italy) and in the shell and yolk of six eggs from the island of Linosa (Sicily, Italy). For the analysis of the heavy metals, we used the analytical procedures in accordance with the EPA 200.8 method supplemented by EPA 6020b with three replicates for each measurement. The elements analysed showed different organotropism even if the liver showed higher levels of bioaccumulation. Turtles’ tissues showed the highest values of iron in the liver, followed by zinc in the heart and arsenic in the kidney. Regarding eggs, zinc, iron, and barium were dominant in the yolk and iron, boron, and copper in the eggshell. From the analyses carried out the worrying levels of arsenic and cadmium in the kidneys and liver of C. caretta raise questions about the risk related to exposure to these non-essential elements. This study highlights the importance of multi-element biomonitoring by increasing knowledge on the biodistribution of 18 heavy metals and the related potential risks for C. caretta. We also exploring for the first time the presence of several heavy metals in the eggs and their possible implication for the survival of the species.
Bioelectric Fields at the Beginnings of Life

The consensus on the origins of life is that it involved organization of prebiotic chemicals according to the underlying principles of thermodynamics to dissipate energy derived from photochemical and/or geochemical sources. Leading theories tend to be chemistry-centric, revolving around either metabolism or information-containing polymers first. However, experimental data also suggest that bioelectricity and quantum effects play an important role in biology, which might suggest that a further factor is required to explain how life began. Intriguingly, in the early part of 20th century, the concept of the “morphogenetic field” was proposed by Gurwitsch to explain how the shape of an organism was determined, while a role for quantum mechanics in biology was suggested by Bohr and Schrödinger, among others. This raises the question as to the potential of these phenomena, especially bioelectric fields, to have been involved in the origin of life. It points to the possibility that as bioelectricity is universally prevalent in biological systems today, it represents a more complex echo of an electromagnetic skeleton which helped shape life into being. It could be argued that as a flow of ions creates an electric field, this could have been pivotal in the formation of an energy dissipating structure, for instance, in deep sea thermal vents. Moreover, a field theory might also hint at the potential involvement of nontrivial quantum effects in life. Not only might this perspective help indicate the origins of morphogenetic fields, but also perhaps suggest where life may have started, and whether metabolism or information came first. It might also help to provide an insight into aging, cancer, consciousness, and, perhaps, how we might identify life beyond our planet. In short, when thinking about life, not only do we have to consider the accepted chemistry, but also the fields that must also shape it. In effect, to fully understand life, as well as the yin of accepted particle-based chemistry, there is a yang of field-based interaction and an ethereal skeleton.
Brain metastases from non-small cell lung carcinoma: an overview of classical and novel treatment strategies

Background The development of brain metastases is a common problem in patients diagnosed with non-small cell lung carcinoma (NSCLC). Technological advances in surgery and radiotherapy have allowed greater local control. Moreover, the emergence of targeted therapies and immunotherapy with greater activity on the central nervous system than classical chemotherapy have given way to new strategies in the treatment of brain metastases. We review the current role of local treatments, surgery and radiotherapy, and the most effective combination strategies with the new systemic treatments. Relevance for patients Brain metastases frequently occur during the course of NSCLC. In recent years, a range of treatments have appeared, such as targeted treatments or immunotherapy, with greater activity at the brain level than classical chemotherapy. Radiotherapy treatment is also now much more conformal and ablative doses can be delivered to the volume of the metastatic area, providing greater local control and less neurological toxicity. However, surgery is still required in cases where anatomopathological specimens are needed and when compressive effects appear. An important challenge is how to combine these treatments to achieve the best control and minimise patients’ neurological impairments, especially because of limited experience with the new target drugs, and the unknown toxicity of the different combinations. Future research should therefore focus on these areas in order to establish the best strategies for the treatment of brain metastases from non-small cell lung cancer. Core tips In this work, we intend to elucidate the best therapeutic options for patients diagnosed with brain metastases of NSCL, which include: surgery, WBRT, radiosurgery or systemic treatment, and the most effective combinations and timings of them, and the ones with the lowest associated toxicity.
A Panel of Eight miRNAs Is Deregulated in HTLV-2 Infected PBMCs and BJABGu Cell Line

Despite human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 being retroviruses closely related at a genomic level, HTLV-2 differs from HTLV-1 in terms of pathogenicity in both single infection and coinfection contexts. Moreover, the HTLV-2 association with clinical outcomes is still debated and several mechanisms underlying HTLV-2 infection remain unexplored as well. Cellular miRNAs are key factors in the post-transcriptional regulation of gene expression and they are known to be potential targets for several pathogens to control the host microenvironment and, in particular, escape immune responses. Here, we identified a HTLV-2-related signature of eight miRNAs (miR-125a-3p, miR-381-3p, miR-502-5p, miR-708-5p, miR-548d-5p, miR-548c-5p, miR-1-3p, and miR-511-5p) in both HTLV-2 infected PBMC and BJABGu cell lines. Altered miRNA expression patterns were correlated with the impairment of Th cell differentiation and signaling pathways driven by cytokines and transcriptional factors such as the Runt-related transcription factor (RUNX) family members. Specifically, we demonstrated that the RUNX2 protein was significantly more expressed in the presence of Tax-2 compared with Tax-1 in an in vitro cell model. To the best of our knowledge, these data represent the first contribution to elucidating the HTLV-2 mediated alteration of host cell miRNA profiles that may impact on HTLV-2 replication and persistent infection.
Glycerin levels for crossbred heifers supplemented in pasture: intake behavior - 10.4025/actascianimsci.v34i1.12520

The effect of glycerin inclusion on the intake behavior of heifers was analyzed. During the 102-day experimental period, thirty-six 13-month old heifers, average initial weight 226±12 kg, were distributed in a completely randomized design with four treatments and nine replications: G0.0 = control, G2.8 = 2.8%, G6.1 = 6.1%, and G9.1 = 9.1% glycerin in DM intake. Intake behavior was undertaken by monitoring animal activities for 24 hours every five minutes. The inclusion of glycerin in the diet resulted in a linear decrease in grazing time, linear increase in idle time and quadratic effect on trough time. Moreover, glycerin inclusion did not affect the number of grazing and rumination periods. The number of idle periods showed a quadratic effect, whereas trough period decreased linearly with increasing glycerin. Glycerin did not affect grazing time and rumination period. Idle time increased linearly with increasing glycerin in the diets. Time had a quadratic effect and feeding and total chewing time showed a linear decrease with glycerin inclusion in the diets
Music Therapy in Mental Health and Emotional Diversion of Primary and Secondary School Students

The purpose of this paper is to provide a group music therapy intervention for elementary and middle school students with mood disorders through music therapy. To explore the improvement of group music therapy on the dysphoria and state of adolescent patients with mood disorders and to explore the relationship with self-identity. A music activity-based mental health education curriculum was designed based on the results of the current survey, while two homogenous classes were selected as the experimental and control classes; subsequently, the experimental teaching of the music activity-based mental health education curriculum was conducted in the experimental class, and the regular school mental health education curriculum was conducted in the control class, and the pre- and postexperimental scale tests were used to analyze that the curriculum of this study had a positive effect of this study's curriculum on elementary school students' positive emotions analyzed through pre- and postexperimental scale tests. The music activity-based mental health education program had a significant positive effect on the overall level of positive emotions of elementary school students, especially in the positive emotion index, happiness index, mental toughness, goal focus, and interpersonal assistance factor. The positive psychology-oriented music activity-based mental health education curriculum is well suited for elementary and middle school students, especially for upper elementary and middle school students. The music activity-based mental health education curriculum realizes the value of applying positive psychology to mental health education efforts at the elementary school level and flexibly uses a variety of related theories to promote positive emotional experiences for elementary and middle school students.
Outcomes of early vitrectomy for endophthalmitis after cataract surgery in delta population, Egypt, 2015–2020

Purpose To evaluate the outcomes of early pars-plana vitrectomy (PPV) in the management of acute onset endophthalmitis after cataract surgery. Study design Retrospective observational study. Patients and methods We collected data from 11 patients who were diagnosed as acute infectious endophthalmitis within 6 weeks after cataract surgery, from January 2015 to December 2020 and had undergone early 23-G PPV and were followed up for 3 months. We analyzed factors that may affect prognosis and final visual outcomes. Results The mean age was 58±5 years, there was male predominance (72.7%). The mean axial length was 24.76±1.58 mm. The baseline best-corrected visual acuity was 2.3 logMAR and was improved to 1.2 logMAR at the third month (P<0.001). Mixed air/fluid intraocular tamponade was used in 63.6% of patients. About half of the cases had positive cultures (54.5%), and the most frequent organism was Staphylococcus aureus (66.7%). Retinal detachment was reported in 36.4% of patients. The preoperative factors correlated with final best-corrected visual acuity were posterior vitreous detachment and intraocular tamponade. Conclusions Early PPV for acute-onset endophthalmitis after cataract surgery aided in improving final visual outcome and preserving structural and functional integrity of the globe, thus preventing late complications that could affect patients’ quality of life. Factors that influence the final visual outcome were intraocular tamponade and posterior vitreous detachment.