Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of patient, surgical, and implant design factors on predicted tray–bone interface micromotions in cementless total knee arthroplasty

Micromotion magnitudes exceeding 150 µm may prevent bone formation and limit fixation after cementless total knee arthroplasty (TKA). Many factors influence the tray–bone interface micromotion but the critical parameters and sensitivities are less clear. In this study, we assessed the impacts of surgical (tray alignment, tibial coverage, and resection surface preparation), patient (bone properties and tibiofemoral kinematics), and implant design (tray feature and surface friction) factors on tray–bone interface micromotions during a series of activities of daily living. Micromotion was estimated via three previously validated implant‐bone finite element models and tested under gait, deep knee bending, and stair descent loads. Overall, the average micromotion across the tray–bone cementless contact interface ranged from 9.3 to 111.4 µm, and peak micromotion was consistently found along the anterior tray edge. Maximizing tibial coverage above a properly sized tibial tray (an average of 12.3% additional area) had minimal impact on micromotion. A 1 mm anterior tray alignment change reduced the average micromotion by an average of 16.1%. Two‐degree tibial angular resection errors reduced the area for bone ingrowth up to 48.1%. Differences on average micromotion from ±25% changes in bone moduli were up to 75.5%. A more posterior tibiofemoral contact due to additional 100 N posterior force resulted in an average of 79.3% increase on average micromotion. Overall, careful surgical technique, patient selection, and controlling kinematics through articular design all contribute meaningfully to minimizing micromotion in cementless TKA, with centralizing the load transfer to minimize the resulting moment at the anterior tray perimeter a consistent theme.
Metamorphosis of neutrophil transcriptional programme during Leishmania infection

The role of neutrophils in the course of Leishmania infection remains controversial, displaying tremendous variability depending on the species of parasite, stage of infection, host genetic background, and methodological discrepancies among studies. Although neutrophils have long been categorized as short‐lived cells with limited capacity to express proteins de novo, recent advances have revealed significant plasticity in neutrophil transcriptional programmes and intrapopulation heterogeneity, which can be regulated by both intrinsic and extrinsic factors that together determine the profile of neutrophil effector response. In this review, we focus on the current understanding of neutrophil transcriptional plasticity, neutrotime, evidence of Leishmania‐mediated alterations in neutrophil transcriptome leading to the rise of subpopulations, and finally, functional implications of those findings to the course of Leishmania infection.
No Changes in Body Composition in NCAA Division I Collegiate Football Players because of COVID-19 Restrictions

Abstract Czeck, MA, Roelofs, EJ, Evanoff, NG, and Dengel, DR. No Changes in body composition in NCAA Division I Collegiate Football Players due to COVID-19 restrictions. J Strength Cond Res 36(6): 1749–1752, 2022—The purpose of this study was to explore the impact of coronavirus disease 2019 (COVID-19) restrictions on body composition, assessed by dual x-ray absorptiometry (DXA), between the 2020 postseason (pre–COVID-19 restrictions) and the 2021 postseason (post–COVID-19 restrictions) in collegiate football players (n = 50). In addition, a subset of athletes (n = 23) was used to explore body composition variables across 4 postseason time points. Body composition variables assessed were total and regional body fat percent, total mass, lean mass, fat mass, bone mineral content, bone mineral density, and visceral adipose tissue mass. Paired t-tests were used to determine differences between the 2020 postseason and the 2021 postseason in body composition variables. Analysis of variance with Tukey HSD post hoc tests assessed significant differences in total and regional body composition across 4 years while adjusting for multiple comparisons. There were no significant differences (p > 0.05) between postseason 2020 and postseason 2021 for all measures of body composition. In a subset of athletes, body composition was analyzed over a 4-year period of time. There were no significant differences between all 4 time points for all measures of body composition. In conclusion, body composition variables in this study's subjects were not affected because of coronavirus disease 2019 restrictions or over 4 years of their collegiate football career.
Influence of adaptive video gaming on quality of life and social relationships

ABSTRACT In recent years, the field of adaptive video gaming has been growing rapidly. However, its acceptance as an integral service within the rehabilitation field has been slow to develop and no studies have examined the benefits of providing adaptive gaming services for individuals with disabilities. 110 participants with 6 months or more of adaptive gaming experience took part in a self-administered survey which comprised of questions assessing gaming habits, quality of life, and social relationships. Most participants either Agreed or Strongly Agreed that adaptive gaming has had a significant positive influence on their quality of life (90.9%), satisfaction with life (87.3%), and social relationships (67.2%). Two thirds of participants reported using their adaptive equipment for tasks other than gaming. Individuals who game more often, and with others, had significantly higher Social Relationship scores (p = 0.007; p = 0.044), and gaming frequency had a significant positive correlation with the overall influence of adaptive gaming (p = 0.002). There are possible quality of life and social benefits from participation in adaptive gaming, as well as translation to functional tasks. Furthermore, gaming more frequently, gaming with others, and using adaptive gaming equipment for other tasks seems to correlate with greater benefits from adaptive gaming.
Association between alexithymia and substance use: A systematic review and meta‐analysis

Alexithymia has been associated with substance use, but the magnitude of the association has not been evaluated and sub‐group differences, if any, are unknown. The aim of this meta‐analysis is to systematically review the association between alexithymia and substance use (alcohol or illicit drugs). We identified studies through a systematic review of PubMed and Web of Science and obtained a total of 52 publications using the Toronto Alexithymia Scale‐20 scale. Random effects meta‐analysis was used to evaluate the overall and sub‐group associations. Of the studies, 50 were cross‐sectional and two longitudinal. Alexithymia was associated with any substance use (Cohen’s d = 0.62, 95% confidence interval [CI] 0.49–0.76), with little difference between estimates for use of alcohol or illicit drugs. A stronger association was observed for the alexithymia dimension “Difficulty in Identifying Feelings” (d = 0.64, 95% CI = 0.47–0.81) and “Difficulty in Describing Feelings” (d = 0.44, 95% CI = 0.32–0.55) than for “Externally Oriented Thinking” (d = 0.19, 95% CI = 0.09–0.28). The association was stronger in studies with clinical patient populations (d = 0.83, 95% CI = 0.62–1.05) than in those investigating general or student populations, and in studies with a majority of male rather than female participants. These findings suggest a strong overall association between alexithymia and substance use and a very strong association among clinical patient populations. The association may be stronger with the emotion‐related dimensions than with the cognition‐related dimension of alexithymia. As nearly all the studies were cross‐sectional, more longitudinal studies are needed.
Characterization Of The Of Red Fresh Tomato Value Chain In Mexico , Caracterizacion De La Cadena De Valor Del Tomate Rojo Fresco En Mexico

Agriculture is an important activity globally for its contribution to food production for human and livestock consumption. It is important to ensure quality at every stage of the process, from production to marketing, so that healthy products are provided and priced according to quality. Value Chain study becomes more important for its impact on the local economy. Therefore, it is important to study value chains considering the different participants in the chain links. The aim of this study was to perform the characterization of the Value Chain of fresh tomato in Mexico proposed by the National Council of Producers of Tomato NPO (Consejo Nacional de Productores de Tomate A.C.in Spanish). This was done through a documentary analysis that considers this product sector, as well as the identification and characterization of links involved in the production process and marketing. When the analysis of tomato Value Chains was completed, primary activities were identified, as well as support. In the link marketing a high dependence of intermediaries is required to get the product to the consumer
Boosting prosocial career aspirations: Loving‐kindness meditation relates to higher communal career goals in youth

Wanting to help others and benefit society in one's future career are examples of communal career goals. Raising these goals in youth should increase interest in HEED‐occupations (Healthcare, Early Education, Domestic, and the Domestic fields) which are strongly gender‐skewed and face labor shortage. Research has yet to find ways to increase communal career goals. In this study, we test the novel hypothesis that after listening to a brief loving‐kindness meditation, participants will rate stronger communal career goals, as compared to controls. In three experimental studies, volunteering high‐school students (Study 1 and 3) and university students (Study 2) listened to a 12‐min recording of the meditation with the explicit purpose of investigating its effect on stress. They thereafter filled out an apparently unrelated career goal survey. We compared the results with a control group that just rated the career goals (Studies 1–3) and a control group that listened to calm music before filling out the survey (Study 2 and 3). The results showed that the high‐school students rated higher communal career goals after listening to the meditation, as compared to controls. We did not replicate the result in the sample of university students, which could relate to adults having less flexible career goals than youth, or to a ceiling effect in communal goals. This is the first study that has demonstrated a method with the potential of increasing communal career goals in youth. In addition to increasing interest in HEED, raising communal goals could benefit society, since they are intrinsically prosocial.
PSB0788 ameliorates maternal inflammation‐induced periventricular leukomalacia-like injury

Statement of Retraction We, the Publisher of the journal Bioengineered, have retracted the following article: Yilu Li, Dan Wang, Zhuoyang Li & Zhi Ouyang . PSB0788 ameliorates maternal inflammation‐induced periventricular leukomalacia-like injury. Bioengineered. 2022; 13(4): 10224-10234. DOI: 10.1080/21655979.2022. 2061296 Since publication, the authors have raised significant concerns about the reliability of the data presented in the article. As the Editor and Publisher also have concerns about the integrity of the reported results, all parties have agreed to retract the article to ensure correction of the scholarly record. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
An Artificial Intelligence-based Mammography Screening Protocol for Breast Cancer: Outcome and Radiologist Workload.

Background Developments in artificial intelligence (AI) systems to assist radiologists in reading mammograms could improve breast cancer screening efficiency. Purpose To investigate whether an AI system could detect normal, moderate-risk, and suspicious mammograms in a screening sample to safely reduce radiologist workload and evaluate across Breast Imaging Reporting and Data System (BI-RADS) densities. Materials and Methods This retrospective simulation study analyzed mammographic examination data consecutively collected from January 2014 to December 2015 in the Danish Capital Region breast cancer screening program. All mammograms were scored from 0 to 10, representing the risk of malignancy, using an AI tool. During simulation, normal mammograms (score < 5) would be excluded from radiologist reading and suspicious mammograms (score > recall threshold [RT]) would be recalled. Two radiologists read the remaining mammograms. The RT was fitted using another independent cohort (same institution) by matching to the radiologist sensitivity. This protocol was further applied to each BI-RADS density. Screening outcomes were measured using the sensitivity, specificity, workload, and false-positive rate. The AI-based screening was tested for noninferiority sensitivity compared with radiologist screening using the Farrington-Manning test. Specificities were compared using the McNemar test. Results The study sample comprised 114 421 screenings for breast cancer in 114 421 women, resulting in 791 screen-detected, 327 interval, and 1473 long-term cancers and 2107 false-positive screenings. The mean age of the women was 59 years ± 6 (SD). The AI-based screening sensitivity was 69.7% (779 of 1118; 95% CI: 66.9, 72.4) and was noninferior (P = .02) to the radiologist screening sensitivity of 70.8% (791 of 1118; 95% CI: 68.0, 73.5). The AI-based screening specificity was 98.6% (111 725 of 113 303; 95% CI: 98.5, 98.7), which was higher (P < .001) than the radiologist specificity of 98.1% (111 196 of 113 303; 95% CI: 98.1, 98.2). The radiologist workload was reduced by 62.6% (71 585 of 114 421), and 25.1% (529 of 2107) of false-positive screenings were avoided. Screening results were consistent across BI-RADS densities, although not significantly so for sensitivity. Conclusion Artificial intelligence (AI)-based screening could detect normal, moderate-risk, and suspicious mammograms in a breast cancer screening program, which may reduce the radiologist workload. AI-based screening performed consistently across breast densities. © RSNA, 2022 Online supplemental material is available for this article.
Diallel and stability analysis of kenaf (Hibiscus cannabinus L.) in South Africa

i DECLARATION I declare that the thesis hereby submitted by me for the Masters degree at the University of the Free State is my own independent work and has not previously been submitted by me at another university/faculty. I further more cede copyright of the thesis in favour of the University of the Free State. South Africa ii DEDICATION This piece of work is dedicated to my parents, who sent me to school and encouraged me to fulfill my dream 谨以此文献给我敬爱的父母和伟大的祖国 iii ACKNOWLEDGEMENTS I would like to thank the following persons and organisations for their contribution to complete this study. Department of Plant Sciences for providing the research facilities and financial aid. Ms. Sadie Geldenhuys for providing excellent administrative support throughout my study. All staff and students in Plant Breeding, for their continuous guidance and friendship. My fiancee: Zhou YanPing, and my brother: Liu Tao, for their constant support, encouragement and understanding especially during all the difficult times. All my friends, especially Dr Auger A. and Mr Yu Z. , for their patience and support. Moreover, I consider it a wise decision on my part to study at the University of the Free State.
Author's Reply to Discussion on "Design of piled bridge abutments on soft clay for loading from lateral soil movements"

Piles supporting bridge abutments on soft clay may be loaded laterally from horizontal soil movements generated by the approach embankment. The design of piles loaded by lateral soil movements is problematic in that existing design approaches are generally inconsistent or show poor correlation with available data. New empirical design charts are presented to allow an assessment of maximum pile bending moment and pile head deflection based on the relative soil-pile stiffness and current loading level. A new analytical approach is also developed on the basis of a simple deformation mechanism. The method accounts for the main features of the problem through an approximate representation of the embankment-soil-pile interaction, and is shown to compare favourably with centrifuge model test data. Recommendations for the design of pile groups for loading from lateral soil movements are also given. Les mouvements horizontaux du sol crees par le remblai sont susceptibles d'engendrer des contraintes laterales dans .
Four-Year Effects of a 2-Year Nutrition and Gender Sensitive Agricultural Program on Women’s Nutritional Status, Knowledge, and Empowerment in Rural Burkina Faso

Background: Little is known about the sustained effects of nutrition- and gender-sensitive agricultural programs (NSAPs) after they end. Objectives: To examine the 4-year effects (2010-2014) of a 2-year NSAP (2010-2012) on women’s outcomes in rural Burkina Faso. Methods: We used baseline (2010) and endline (2012) data from a cluster-randomized controlled trial of Helen Keller International’s Enhanced Homestead Food Production (EHFP) program and baseline (2014) data from a new program. We included 134 women: 82 who participated in the 2-year EHFP program (treatment) and 52 who did not (control). We examined program (2010-2012), post-program (2012-2014), and overall 4-year effects (2010-2014) using difference-in-difference analysis (DID). Results: We found significant positive program effects (2010-2012) on women’s underweight prevalence (DID: 16.44 percentage points [pp]; P = .09) and on women’s knowledge about appropriate age to introduce liquids (DID: 28.40 pp; P = .01). Although there were no significant postprogram effects (2012-2014), differences found in 2012 between the treatment and control group were sustained resulting in an overall 4-year (2010-2014) reduction in women’s underweight prevalence (DID: 18.26 pp; P = .02) and an improvement in women’s knowledge about appropriate age to introduce liquids (DID: 31.29 pp; P = .02). We observed no postprogram or overall 4-year effects on women’s knowledge of child feeding and handwashing practices or women’s empowerment. Conclusions: Nutrition- and gender-sensitive agricultural programs demonstrate potential for sustained improvements in women’s nutritional status and nutritional knowledge. Postprogram assessments of NSAPs should be embedded in program evaluations to help further understand the potential of NSAPs to generate sustainable impacts on women’s outcomes.
Coevolutionary analysis reveals a distal amino acid residue pair affecting the catalytic activity of GH5 processive endoglucanase from Bacillus subtilis BS‐5

EG5C‐1, processive endoglucanase from Bacillus subtilis, is a typical bifunctional cellulase with endoglucanase and exoglucanase activities. The engineering of processive endoglucanase focuses on the catalytic pocket or carbohydrate‐binding module tailoring based on sequence/structure information. Herein, a computational strategy was applied to identify the desired mutants in the enzyme molecule by evolutionary‐coupling analysis; subsequently, four residue pairs were selected as evolutionary mutational hotspots. Based on iterative‐saturation mutagenesis and subsequent enzymatic activity analysis, a superior mutant K51T/L93T has been identified away from the active center. This variant had increased specific activity from 4170 U/µmol of wild‐type (WT) to 5678 U/µmol towards carboxymethyl cellulose‐Na and an increase towards the substrate Avicel from 320 U/µmol in WT to 521 U/µmol. In addition, kinetic measurements suggested that superior mutant K51T/L93T had a high substrate affinity (Km) and a remarkable improvement in catalytic efficiency (kcat/Km). Furthermore, molecular dynamics simulations revealed that the K51T/L93T mutation altered the spatial conformation at the active site cleft, enhancing the interaction frequency between active site residues and substrate, and improving catalytic efficiency and substrate affinity. The current studies provided some perspectives on the effects of distal residue substitution, which might assist in the engineering of processive endoglucanase or other glycoside hydrolases.
Wheelchair service provision education for healthcare professional students, healthcare personnel and educators across low- to high-resourced settings: a scoping review

Abstract Purpose This review aimed to collate and summarize available research literature about wheelchair service provision education available to healthcare professional students, healthcare personnel and educators across low- to high-resourced settings. Methods The Joanna Briggs Institute methodological steps for scoping reviews were followed. Included studies were mainly sourced from Medline, Embase, CINAHL, Scopus, Academic Search Complete and ProQuest. Independent title, abstract and full-text screening with defined inclusion and exclusion criteria was performed. All screening and extraction were performed independently by two authors. A thematic approach was used to synthesize results. Data extracted from included studies were charted according to a template that we created. The study quality was also appraised. Results A total of 25 articles were included (11, 36% from high-income settings) with 12 (48%) observational studies and 13 (52%) experimental studies. The literature addressed three main topics: (1) assessing wheelchair service provision knowledge, (2) implementing training interventions using in-person, online and/or hybrid learning approaches and (3) describing current wheelchair service provision education globally. The most frequently reported training programs used were the Wheelchair Skills Program and the World Health Organization Wheelchair Service Training Package – Basic Level. Conclusion Limited information has been published about the integration of wheelchair content into the curricula of professional rehabilitation programs. Efforts to build international partnerships, improve the quality and currency of training programs and build resources that can assist educators in the integration of wheelchair-related content into professional rehabilitation programs should be prioritized. Implications for Rehabilitation This is the first review that examined and synthesized the current state of wheelchair service provision education for rehabilitation students and personnel across low- to high-income countries. Findings from this review indicate that there is limited information about the integration of wheelchair-related content into professional rehabilitation programs. Efforts to build international partnerships, standardize wheelchair service provision content and evaluation and integrate training into professional rehabilitation programs worldwide should be prioritized.