Miracle-dz/UniFAR-FTUs huggingface dataset:
Post-incident psychosocial interventions after a traumatic incident in the workplace: a systematic review of current research evidence and clinical guidance

ABSTRACT Background: After a traumatic incident in the workplace organisations want to provide support for their employees to prevent PTSD. However, what is safe and effective to offer has not yet been established, despite many organisations offering some form of intervention after a traumatic event. Objective: To systematically review the evidence for post-incident psychosocial interventions offered within one month of a workplace trauma, and to compare the content, effectiveness and acceptability of these interventions. Given the lack of a yet clearly established evidence-base in this field, we sought to examine both published empirical research as well as guidelines published by expert groups working with staff in high-risk roles. Methods: We conducted systematic searches for empirical research across bibliographic databases and searched online for clinical practice guidelines to April 2023. We were also referred to potentially relevant literature by experts in workplace trauma. Both empirical research and clinical guidelines were appraised for their quality. Results: A total of 80 research studies and 11 clinical practice guidelines were included in the review. Interventions included Critical Incident Stress Debriefing (CISD), Critical Incident Stress Management (CISM), unspecified Debriefing, Trauma Risk Management (TRiM), Psychological First Aid (PFA), EMDR, CBT and group counselling. Most research and guidance were of poor quality. The findings of this review do not demonstrate any harm caused by CISD, CISM, PFA, TRiM, EMDR, group counselling or CBT interventions when delivered in a workplace setting. However, they do not conclusively demonstrate benefits of these interventions nor do they establish superiority of any specific intervention. Generic debriefing was associated with some negative outcomes. Current clinical guidelines were inconsistent with the current research evidence base. Nevertheless, interventions were generally valued by workers. Conclusions: Better quality research and guidance is urgently needed, including more detailed exploration of the specific aspects of delivery of post-incident interventions. HIGHLIGHTS Organisations often seek to provide some form of psychosocial intervention after a traumatic event in the workplace. Previous reviews have contraindicated particular forms of ‘debriefing’, however, the evidence for post-incident psychosocial interventions in the workplace has not previously been systematically reviewed. Research evidence was generally of poor quality with limited evidence of effectiveness and clinical guidelines were inconsistent with the evidence. Nevertheless, research did not demonstrate harm from most established interventions and support was valued by workers.
Numerical modelling of rise and fall of a dense layer in salt diapirs

This thesis uses results of systematic numerical models to argue that externally inactive salt structures, which are potential targets for radioactive waste disposal, might be internally active due to the presence of dense layers or blocks within a salt layer.The three papers that support this thesis use the Gorleben salt diapir (NW Germany), which was targeted as a future final repository for high-grade radioactive waste, as a general guideline.The first two papers present systematic studies of the parameters that control the development of a salt diapir and how it entrains a dense anhydrite layer. Results from these numerical models show that the entrainment of a dense anhydrite layer within a salt diapir depends on four parameters: sedimentation rate, viscosity of salt, perturbation width and the stratigraphic location of the dense layer. The combined effect of these four parameters, which has a direct impact on the rate of salt supply (volume/area of the salt that is supplied to the diapir with time), shape a diapir and the mode of entrainment. Salt diapirs down-built with sedimentary units of high viscosity can potentially grow with an embedded anhydrite layer and deplete their source layer (salt supply ceases). However, when salt supply decreases dramatically or ceases entirely, the entrained anhydrite layer/segments start to sink within the diapir. In inactive diapirs, sinking of the entrained anhydrite layer is inevitable and strongly depends on the rheology of the salt, which is in direct contact with the anhydrite layer. During the post-depositional stage, if the effective viscosity of salt falls below the threshold value of around 1018-1019 Pa s, the mobility of anhydrite blocks might influence any repository within the diapir. However, the internal deformation of the salt diapir by the descending blocks decreases with increase in effective viscosity of salt.The results presented in this thesis suggest that it is highly likely that salt structures where dense and viscous layer/blocks are present undergo an internal deformation processes when these dense blocks start sinking within the diapir. Depending on size and orientation of these blocks, deformation pattern is significantly different within the diapir. Furthermore, model results applied to the Gorleben diapir show that the rate of descent of the entrained anhydrite blocks differs on different sides of the diapir. This suggests that if the anhydrite blocks descent within the Gorleben diapir, they initiate an asymmetric internal flow within it.
Stratigraphy and structure of the western Moine and the problem of Moine orogenesis

The stratigraphy and major structure of some 650 km2 of Precambrian, Moine metasediments in western Scotland are discussed and it is shown that at least four major deformation phases involving primary isoclinal folding with fold amplitudes of at least 20 km, and two major metamorphic episodes affect both the Lewisian basement and the Moine cover. It is argued that there is sufficient evidence to regard the first two deformation phases together with the earlier metamorphism as Precambrian in age and the subsequent deformations and metamorphism as Caledonian.
A Review on Microbiological Source Attribution Methods of Human Salmonellosis: From Subtyping to Whole-Genome Sequencing

Salmonella is one of the main causes of human foodborne illness. It is endemic worldwide, with different animals and animal-based food products as reservoirs and vehicles of infection. Identifying animal reservoirs and potential transmission pathways of Salmonella is essential for prevention and control. There are many approaches for source attribution, each using different statistical models and data streams. Some aim to identify the animal reservoir, while others aim to determine the point at which exposure occurred. With the advance of whole-genome sequencing (WGS) technologies, new source attribution models will greatly benefit from the discriminating power gained with WGS. This review discusses some key source attribution methods and their mathematical and statistical tools. We also highlight recent studies utilizing WGS for source attribution and discuss open questions and challenges in developing new WGS methods. We aim to provide a better understanding of the current state of these methodologies with application to Salmonella and other foodborne pathogens that are common sources of illness in the poultry and human sectors.
Projecting and Forecasting Winter Precipitation Extremes and Meteorological Drought in California Using the North Pacific High Sea Level Pressure Anomaly

AbstractLarge-scale climatic indices have been used as predictors of precipitation totals and extremes in many studies and are used operationally in weather forecasts to circumvent the difficulty in obtaining robust dynamical simulations of precipitation. The authors show that the sea level pressure North Pacific high (NPH) wintertime anomaly, a component of the Northern Oscillation index (NOI), provides a superior covariate of interannual precipitation variability in Northern California, including seasonal precipitation totals, drought, and extreme precipitation intensity, compared to traditional ENSO indices such as the Southern Oscillation index (SOI), the multivariate ENSO index (MEI), Nino-3.4, and others. Furthermore, the authors show that the NPH anomaly more closely reflects the influence of Pacific basin conditions over California in general, over groups of stations used to characterize statewide precipitation in the Sierra Nevada range, and over the southern San Francisco Bay region (NASA Ames R.
Development of LuxIA, a Cloud-Based AI Diabetic Retinopathy Screening Tool Using a Single Color Fundus Image

Purpose Diabetic retinopathy (DR) is the leading cause of vision impairment in working-age adults. Automated screening can increase DR detection at early stages at relatively low costs. We developed and evaluated a cloud-based screening tool that uses artificial intelligence (AI), the LuxIA algorithm, to detect DR from a single fundus image. Methods Color fundus images that were previously graded by expert readers were collected from the Canarian Health Service (Retisalud) and used to train LuxIA, a deep-learning–based algorithm for the detection of more than mild DR. The algorithm was deployed in the Discovery cloud platform to evaluate each test set. Sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve were computed using a bootstrapping method to evaluate the algorithm performance and compared through different publicly available datasets. A usability test was performed to assess the integration into a clinical tool. Results Three separate datasets, Messidor-2, APTOS, and a holdout set from Retisalud were evaluated. Mean sensitivity and specificity with 95% confidence intervals (CIs) reached for these three datasets were 0.901 (0.901–0.902) and 0.955 (0.955–0.956), 0.995 (0.995–0.995) and 0.821 (0.821–0.823), and 0.911 (0.907–0.912) and 0.880 (0.879–0.880), respectively. The usability test confirmed the successful integration of LuxIA into Discovery. Conclusions Clinical data were used to train the deep-learning–based algorithm LuxIA to an expert-level performance. The whole process (image uploading and analysis) was integrated into the cloud-based platform Discovery, allowing more patients to have access to expert-level screening tools. Translational Relevance Using the cloud-based LuxIA tool as part of a screening program may give diabetic patients greater access to specialist-level decisions, without the need for consultation.
The interaction between the tropopause inversion layer and the inertial gravity wave activities revealed by radiosonde observations at a midlatitude station

The interaction between the tropopause inversion layer (TIL) and the inertial gravity wave (IGW) activities is first presented by using a high vertical resolution radiosonde data set at a midlatitude station, Boise, Idaho (43.57°N, 116.22°W), for the period 1998–2008. The tropopause‐based vertical coordinate is used for the TIL detection, and for meticulously studying the IGW variation around the TIL, the broad spectral method is used for the IGW extraction. Generally, the TIL at the midlatitude station is stronger and thicker in winter and spring, which is consistent with previous studies. Our study confirmed the intense interaction between the TIL and IGW. It is found that the TIL not only could inhibit the upward propagation of IGWs from below but also imply the possible excitation links between the TIL and IGW. The results also indicate that the enhanced wind shear layer just 1 km above the tropopause may result in instability and finally leads to the IGW breaking and intensive turbulence. Subsequently, the IGW‐induced intensive turbulence leads to strong wave energy dissipation and a downward heat flux. This downward heat transportation could significantly cool the tropopause, while it has only negligible thermal effect on the atmosphere above the tropopause. Then, the IGW‐induced cooling at the tropopause makes the tropopause colder and sharper and finally forms the TIL. These suggest besides previously proposed mechanisms that IGWs also contribute greatly to the formation of TIL, which is consistent with a recent related simulation study.
Predicting ventilator-associated pneumonia in elderly patients requiring mechanical ventilation through the detection in tracheal aspirates

ABSTRACT Objective In this study, we evaluated the clinical utility of tracheal aspirates α-amylase (AM), pepsin, and lipid-laden macrophage index (LLMI) in the early diagnosis of ventilator-associated pneumonia (VAP) in elderly patients on mechanical ventilation. Methods Within 96 hours of tracheal intubation, tracheal aspirate specimens were collected from elderly patients on mechanical ventilation; AM, pepsin, and LLMI were detected, and we analyzed the potential of each index individually and in combination in diagnosing VAP. Results Patients with VAP had significantly higher levels of AM, pepsin, and LLMI compared to those without VAP (P < 0.001), and there was a positive correlation between the number of pre-intubation risk factors of aspiration and the detection value of each index in patients with VAP (P < 0.001). The area under a receiver operating characteristic (ROC) curve (AUC) of AM, pepsin, and LLMI in diagnosis of VAP were 0.821 (95% CI:0.713–0.904), 0.802 (95% CI:0.693–0.892), and 0.621 (95% CI:0.583–0.824), the sensitivities were 0.8815, 0.7632, and 0.6973, the specificities were 0.8495, 0.8602, and 0.6291, and the cutoff values were 4,321.5 U/L, 126.61 ng/ml, and 173.5, respectively. The AUC for the combination of indexes in diagnosing VAP was 0.905 (95% CI:0.812–0.934), and the sensitivity and specificity were 0.9211 and 0.9332, respectively. In the tracheal aspirate specimens, the detection rate of AM ≥ cutoff was the highest, while it was the lowest for LLMI (P < 0.001). The detection rates of AM ≥ cutoff and pepsin ≥ cutoff were higher within 48 hours after intubation than within 48–96 hours after intubation (P < 0.001). In contrast, the detection rate of LLMI ≥ cutoff was higher within 48–96 hours after intubation than within 48 hours after intubation (P < 0.001). The risk factors for VAP identified using logistic multivariate analysis included pre-intubation aspiration risk factors (≥3), MDR bacteria growth in tracheal aspirates, and tracheal aspirate AM ≥ 4,321.5 U/L, pepsin ≥ 126.61 ng/ml, and LLMI ≥ 173.5. Conclusion The detection of AM, pepsin, and LLMI in tracheal aspirates has promising clinical utility as an early warning biomarker of VAP in elderly patients undergoing mechanical ventilation.
Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity

Abstract Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets. Activation-dependent GPVI metalloproteolysis is primarily mediated by A Disintegrin And Metalloproteinase (ADAM) 10. Regulation of platelet ADAMs activity is not well-defined however Tissue Inhibitors of Metalloproteinases (TIMPs) may play a role. As levels of TIMPs on platelets and the control of ADAMs-mediated shedding by TIMPs has not been evaluated, we quantified the levels of TIMPs on the surface of resting and activated platelets from healthy donors by flow cytometry and multiplex ELISA. Variable levels of all TIMPs could be detected on platelets. Plasma contained significant quantities of TIMP1 and TIMP2, but only trace amounts of TIMP3 and TIMP4. Recombinant TIMP3 strongly ablated resting and activated platelet ADAM10 activity, when monitored using a quenched fluorogenic peptide substrate with ADAM10 specificity. Whilst ADAM10-specific inhibitor GI254023X or ethylenediamine tetraacetic acid (EDTA) could modulate ligand-initiated shedding of GPVI, only recombinant TIMP2 achieved a modest (~20%) inhibition. We conclude that some platelet TIMPs are able to modulate platelet ADAM10 activity but none strongly regulate ligand-dependent shedding of GPVI. Our findings provide new insights into the regulation of platelet receptor sheddase activity. Plain Language Summary What do we know? Platelet receptor GPVI initiates platelet adhesion and aggregation and is proteolytically cleaved from the activated platelet surface The metalloproteinases responsible belong to the ADAMs family of enzymes which are inhibited by TIMPs What did we discover? Plasma contains significant amounts of TIMP1 and TIMP2 Circulating platelets bear significant amounts of TIMPs 1, 2, and 3 Recombinant TIMP3 strongly inhibits resting and activated platelet ADAM10 activity Exogenous addition of TIMP2 mildly blocked ligand-initiated shedding of GPVI What is the impact? TIMPs may modulate ADAM10 activity under resting conditions and stabilize GPVI levels in response to platelet activation Anti-GPVI agents are being evaluated as anti-thrombotic agents, however, acute loss of GPVI in trauma or settings of thrombocytopenia is linked with clinical bleeding Understanding how GPVI levels are regulated is important as agents that modulate GPVI function are emerging as important therapeutics for clinical applications in Thrombosis and Hemostasis fields
Indigenous methods of seed conservation and protection in Uttarakhand Himalaya

In Uttarakhand Himalaya traditional agriculture is the mere way to meet the subsistence needs of the local farming communities. In traditional system of agriculture, local seed material of traditional crop varieties plays an important role for crop production. In such a situation, the protection of seed material and its conservation for future needs is also of very paramount importance. In order to protect the seed material and food grains, local practices by using indigenous plant material and other articles are very useful, eco-friendly and sustainable. In the present study, the investigators have surveyed the entire Uttarakhand Himalaya for documenting the indigenous seed and grain protection practices of the farm households. The indigenous practices are discussed here in the light of Western science. The present investigation was undertaken with the aim of objectives to provide protection to the knowledge of local farmers and document it before it’s lost under the onslaught of development. Another important objective was to pave the way for values addition in the indigenous knowledge by the scientists, researchers and development workers for sustainable development.
Adoption and extent of conservation agriculture practices among smallholder farmers in Malawi

Understanding factors affecting farmers' adoption of improved technologies is critical to success of conservation agriculture (CA) program implementation. This study, which explored the factors that determine adoption and extent of farmers' use of the three principles of CA (i.e., minimum soil disturbance, permanent soil cover with crop residues, and crop rotations), was conducted in 10 target communities in 8 extension planning areas in Malawi. The primary data was collected using structured questionnaires administered to individual households. Triangulation with key informant interviews, field observations, and interactive discussions with farmers and farmer groups provided information behind contextual issues underpinning the statistical inferences. From a total of 15,854 households in the study areas, it is estimated that 18% of the smallholder farmers had adopted CA, representing an area of about 678 ha (1,675 ac; 2.1% of all cultivated land). Land area under CA constituted about 30% of total cultivated land among adopters. A random sample of 151 adopters and 149 nonadopters proportional with respect to adoption rates was drawn from various communities and interviewed using structured questionnaires. A total of 30 key informant interviews were conducted with stakeholders including staff of Total Land Care, government extension workers, agroinput suppliers, and lead farmers. The first stage of the Heckman model showed that hired labor, area of land cultivated, membership to farmer group, and district influenced farmers' decisions to adopt CA. The second stage of Heckman model results suggested that total cultivated land, duration of practicing CA, and district influenced farmers' decisions to extend their land to CA. Our study can be used to show the agency and social structures that are likely to influence adoption and extent of CA. Future policy should address ways to provide access to information and long-term support to farmers to enable them to embrace the technology fully.
Designing and Validating an Evidence-Based, Shift-to-Shift Handover Bundle for Nurses and Physicians

This article reports a study aimed at developing and validating an evidence-based, shift-to-shift handover bundle for nurses and physicians to be used at shift changes in intensive care and emergency units. Deficient or absent clinical handovers, or failures to transfer information, responsibility, and accountability can have unwanted consequences for hospitalized patients, particularly those at critical areas. Clinical handovers are practiced every day, in many ways, in all institutional health care settings. Despite increasing demand for structured processes to guide clinical handovers, standardized handover bundles for nurses and physicians are limited in the emergency and intensive care unit. As a result of this study, a shift-to-shift handover bundle was created, which was an evidence-based research design. This bundle is expected to be helpful for proper patient transfers between these critical areas, ensuring patient safety and efficient quality management.
Incretin‐based drugs and the risk of diabetic retinopathy among individuals with type 2 diabetes: A systematic review and meta‐analysis of observational studies

The results from the SUSTAIN‐6 trial generated some uncertainty regarding the association between incretin‐based drugs [dipeptidyl peptidase‐4 (DPP‐4) inhibitors and glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs)] and the risk of diabetic retinopathy. Our objective was to synthesize the available evidence from observational studies regarding the use of incretin‐based drugs and the risk of diabetic retinopathy among individuals with type 2 diabetes.
Response of cowpea (Vigna unguiculata L. Walp) to methods and levels of irrigation under varying fertilizer levels in a semi-arid region of Nigeria

Cowpea, an annual legume can be valued as a nutritional supplement to cereals in the semi-arid region of Africa. Fortunately, it tolerates heat and dry conditions and can be grown under irrigated and non-irrigated conditions to boost its low level of production. A study was conducted in the dry seasons of 2001, 2002 and 2003 at Kadawa (11°39’N, 08°02’E ), Nigeria to evaluate the effects of irrigation methods (basin or furrow), irrigation levels (7, 14 or 21-day intervals) and N-P 2 O 5 -K 2 O fertilizer levels (0-0-0, 20-40-20 and 0-40-0) on the performance of cowpea. The growth and yield components were influenced at varying levels by the factors. The use of furrow irrigation method resulted in higher yield, and delay in irrigation up to 14-21 days did not significantly affect the yield. The response to fertilizer levels was significant only in 2003. The result has positive implication on efficient use of resources (water and fertilizer) in irrigated cowpea production in the region.