Miracle-dz/UniFAR-FTUs huggingface dataset:
A Review of Adherence and Predictors of Adherence to the CONSORT Statement in the Reporting of Tuberculosis Vaccine Trials

The statement on Consolidated Standards of Reporting Trials (CONSORT) ensures transparency in the reporting of randomized trials. However, it is unclear if the statement has led to improvement in the quality of reporting of tuberculosis (TB) vaccine trials. We explored the quality of reporting of TB vaccine trials according to the latest version of the CONSORT statement, released in 2010. We searched PubMed and the Cochrane Central Register of Controlled Trials in August 2019. We conducted screening, study selection, and data extraction in duplicate; and resolved differences through discussion. We assessed reporting to be adequate if trials reported at least 75% of the CONSORT 2010 items. We conducted a trend analysis to assess if there was improvement in reporting over time. We also used logistic regression to assess factors associated with adequate reporting. We included 124 trials in the analyses. The mean proportion of adherence was 67.3% (95% confidence interval 64.4% to 70.1%), with only 46 (37%) trials having adequate reporting. There was a significant improvement in the quality of reporting over time (p < 0.0001). Trials published in journals with impact factors between 10 and 20 were more likely to have adequate reporting (odds ratio 9.4; 95% confidence interval 1.30 to 67.8), compared to lower-impact-factor journals. Despite advances over time, the reporting of TB vaccine trials is still inadequate and requires improvement.
Pediatric Orthopaedic Observerships in North America for International Surgeons: The Visitor's Perspective.

BACKGROUND There is substantial disparity in access to surgical care worldwide that largely impacts children in resource-limited environments. Although it has been suggested that surgeons in high-income countries work alongside their overseas peers to bridge this gap, there is limited information regarding the impact of pediatric orthopaedic observerships that are available to international surgeons. This study aimed to assess the perceived impact of such visitations on overseas surgeons, including their professional development and clinical practice. METHODS A survey was distributed to overseas surgeons who participated in a pediatric orthopaedic observership in North America in the years 2009 to 2019. Details were collected regarding each respondent's demographics and observership program, and the impact of this short-term clinical experience as perceived by the visiting surgeon. RESULTS Of the 181 international surgeons from 56 countries who participated in a pediatric orthopaedic observership, most were young male surgeons residing in a middle-income nation. The majority of surgeons observed in outpatient clinics (98%) and in the operating room (96%) and attended educational in-house conferences (92%). Most observers (75%) acknowledged gaining relevant orthopaedic knowledge and clinical skills that improved local patient care, and nearly all (99%) shared the newly acquired knowledge with their peers and trainees. Most (97%) were still living and working in the country that had been their residence at the time of their observership. No noteworthy trends were identified between the income classification of the surgeons' country of residence and their ability to incorporate the acquired skills into their practice. CONCLUSIONS Participating in a North American pediatric orthopaedic observership has a positive perceived impact on the majority of visiting surgeons, with potential gains in clinical skills and knowledge that likely benefit their patients, peers, and trainees. Such participation does not contribute to substantial brain drain and may assist with local capacity building. Identifying ways to increase access to such educational opportunities, particularly for surgeons from lower-income countries, should be explored further.
Obesity-induced Cognitive Impairment in Older Adults: a Microvascular Perspective.

Over two thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.
Developmental enamel defects of primary incisors in preterm infants with very low and extremely low birthweight. A case- control study.

AIM To determine the prevalence of developmental defects of enamel (DDE) in primary incisors of preterm very low birthweight (VLBW) and extremely low birthweight (ELBW) one-year-old infants and to compare the findings with fullterm one-year-old normal birthweight (NBW) infants. MATERIALS AND METHODS All infants were enrolled in the case-control study at birth. Personal information and medical histories were obtained through interviews with parents and from medical hospital records. The presence of DDE in primary incisors was evaluated in 82 one-year old preterm infants delivered with VLBW, in 50 ELBW and in 58 fullterm NBW infants. The data were statistically analysed by ANOVA and chi-square tests, and a statistical significance level p<0.05 was established. Results DDE were diagnosed in 19 (23.2 %) preterm VLBW infants, in 27 (54%) ELBW infants and in 4 (6.9%) infants of the control group. The most frequent DDE found in the case group was hypoplasia in 10 (12.2%) VLBW infants and in 14 (28%) ELBW infants. The opacities were found in 6 (7.3%) VLBW infants and in 8 (16%) ELBW infants. CONCLUSION The results of the study confirmed a significantly higher prevalence of DDE in the primary incisors in preterm ELBW infants than in VLBW infants and than in full term NBW infants.
Comparison of Conformational Phase Behavior for Flexible and Semiflexible Polymers

We employ the recently introduced generalized microcanonical inflection point method for the statistical analysis of phase transitions in flexible and semiflexible polymers and study the impact of the bending stiffness upon the character and order of transitions between random-coil, globules, and pseudocrystalline conformations. The high-accuracy estimates of the microcanonical entropy and its derivatives required for this study were obtained by extensive replica-exchange Monte Carlo simulations. We observe that the transition behavior into the compact phases changes qualitatively with increasing bending stiffness. Whereas the Θ collapse transition is less affected, the first-order liquid-solid transition characteristic for flexible polymers ceases to exist once bending effects dominate over attractive monomer-monomer interactions.
Higher Mortality and Intensive Care Unit Admissions in COVID-19 Patients with Liver Enzyme Elevations

The aim of the present study is to evaluate if an independent association exists between liver enzyme elevations (LEE) and the risk of mortality or intensive care unit (ICU) admissions in patients with COVID-19. This was a single-center observational study, recruiting all consecutive adults with COVID-19. The elevation of aspartate aminotransferase (AST) or alanine aminotransferase (ALT) to the highest level between COVID-19 diagnosis and hospital discharge was categorized according to a standardized toxicity grade scale. In total, 799 patients were included in this study, 39% of which were female, with a mean age of 69.9 (±16.0) years. Of these patients, 225 (28.1%) developed LEE of grade ≥2 after a median of three days (interquartile range (IQR): 0–8 days) from the diagnosis of COVID-19, and they were estimated to have a higher hazard of death or ICU admission (adjusted hazard ratio (aHR): 1.46, 95% confidence interval (CI): 1.14–1.88). The clinical and laboratory variables associated with the development of LEE were male sex, higher respiratory rate, higher gamma glutamyl transpeptidase (GGT) and lower albumin levels at baseline. Among the analyzed treatments, steroids, tocilizumab and darunavir/ritonavir correlated with LEE. In conclusion, LEE were associated with mortality and ICU admission among COVID-19 patients. While the origin of LEE is probably multifactorial, LEE evaluation could add information to the clinical and laboratory variables that are commonly evaluated during the course of COVID-19.
The Generalizability of HERO across 15 Nations: Positive Psychological Capital (PsyCap) beyond the US and Other WEIRD Countries

Recent meta-analyses of positive organizational psychology interventions (POPIs) suggest that interventions that target and improve hope, efficacy, resilience, and optimism (HERO) can be highly effective at improving well-being and positive functioning at work. However, many studies to date have been conducted with samples from the US and other Western, educated, industrialized, rich, and democratic (WEIRD) societies, which raise the concern about the generalizability of theory-driven POPIs. The aim of this study was to examine if the underlying mechanism of one of the most successful POPIs to date, positive psychological capital (PsyCap) based on the HERO model, predicts positive functioning at work across diverse geographical regions and cultures. Using Qualtrics Panel data collected from 3860 employees across 15 nations (Australia, Brazil, China, France, Germany, Great Britain, India, Ireland, Italy, Japan, Netherlands, New Zealand, Philippines, South Africa, and the United States), we found that PsyCap is strongly associated with workplace proactivity, proficiency, adaptivity, and overall work performance across all 15 nations. The results suggest that efforts to develop PsyCap may be effective across national cultures and could be a robust approach for enhancing positive functioning in the global workplace.
Efficacy and safety of baricitinib in 446 patients with rheumatoid arthritis: a real-life multicentre study.

OBJECTIVES Baricitinib, an oral Janus kinase (JAK) 1-2 inhibitor, is currently used along biologic DMARDs (bDMARDs) after the failure of methotrexate (MTX) in rheumatoid arthritis (RA). We investigated the efficacy and safety of baricitinib in real life. METHODS We prospectively enrolled 446 RA patients treated with baricitinib from 11 Italian centres. Patients were evaluated at baseline and after 3, 6, and 12 months. They were arrayed based on previous treatments as bDMARD-naïve and bDMARD-insufficient responders (IR) after the failure or intolerance to bDMARDs. A sub-analysis differentiated the effects of methotrexate (MTX) and the use of oral glucocorticoids (OGC). RESULTS Our cohort included 150 (34%) bDMARD-naïve and 296 (66%) bDMARD-IR patients, with 217 (49%) using baricitinib as monotherapy. Considering DAS-28-CRP as the primary outcome, at 3 and 6 months, 114/314 (36%) and 149/289 (51.6%) patients achieved remission, while those in low disease activity (LDA) were 62/314 (20%) and 46/289 (15.9%), respectively; finally at 12 months 81/126 (64%) were in remission and 21/126 (17%) in LDA. At all-timepoints up to 12 months, bDMARDs-naïve patients demonstrated a better clinical response, independently of MTX. A significant reduction in the OGC dose was observed at 3 and 12 months in all groups. The serum positivity for both rheumatoid factors (RF) and anti-citrullinated protein antibodies (ACPA) conferred a lower risk of stopping baricitinib due to inefficacy. Fifty-eight (13%) patients discontinued baricitinib due to adverse events, including thrombotic events and herpes zoster reactivation. CONCLUSIONS Real-life data confirm the efficacy and safety profiles of baricitinib in patients with RA and provide evidence that drug survival is higher in bDMARDs-naïve and seropositive patients.
Immune Response to Vaccination in Patients with Psoriasis Treated with Systemic Therapies

Psoriasis is a chronic inflammatory skin disease usually treated with immunomodulatory/immunosuppressive agents. The use of these agents has been associated with an increased susceptibility to infections. Vaccination might represent a critical aspect in the management of patients with psoriasis treated with immunomodulatory/immunosuppressive therapies. This narrative review aimed to provide an overview on the immune response to vaccines in subjects treated with systemic agents used to treat patients with moderate to severe psoriasis. Publications appearing in PubMed, Scopus, and ISI–Web of Knowledge database were selected using Medical Subject Headings key terms. Overall, published data confirmed that vaccination with attenuated live vaccines during therapy with immunomodulatory/immunosuppressive therapies should be avoided. For nonlive vaccines, a more favorable safety profile of biologic agents compared to conventional systemic agents is described as the humoral response to vaccines is in general well-preserved. Treatment with cyclosporine and methotrexate is associated with lower antibody titers to vaccines, and thus these agents are better discontinued during vaccination. In contrast, treatment with biological agents is not associated with lower antibody response and can thus be continued safely.
Post-Cranioplasty Complications: Lessons From a Prospective Study Assessing Risk Factors.

ABSTRACT Complication rate related with cranioplasty is described as very high in most of relevant studies. The aim of our study was to try to identify possible factors, that could predict complications following cranioplasty. The authors hypothesized that some physical characteristics on the preoperative brain computed tomography (CT) scan can be predictive for complications.The authors carried out a prospective observational study. All patients were adults after decompressive craniectomy, planned for cranioplasty and had a brain CT scan the day before cranioplasty. Our data pool included demographics, reason of craniectomy, various radiological parameters, the time of cranioplasty after craniectomy, the type of cranioplasty bone flap, and the complications.Twenty-five patients were included in the study. The authors identified statistically significant correlation between time of cranioplasty after craniectomy and the complications, as well as between the type of cranioplasty implant and the complications. There was statistically significant correlation between complications and the distance of the free brain surface from the level of the largest skull defect dimension - free brain surface deformity (FBSD). Moreover, the correlation between FBSD and the time of cranioplasty was statistically significant.It seems that for adult patients with unilateral DC the shorter time interval between craniectomy and cranioplasty lowers the risk for complications. The risk seems to be decreased further, by using autologous bone flap. Low values of the FBSD increase the risk for complications. This risk factor can be avoided, by shortening the time between craniectomy and cranioplasty.
Post-Encoding Stress Does Not Enhance Memory Consolidation: The Role of Cortisol and Testosterone Reactivity

In contrast to the large body of research on the effects of stress-induced cortisol on memory consolidation in young people, far less attention has been devoted to understanding the effects of stress-induced testosterone on this memory phase. This study examined the psychobiological (i.e., anxiety, cortisol, and testosterone) response to the Maastricht Acute Stress Test and its impact on free recall and recognition for emotional and neutral material. Thirty-seven healthy young men and women were exposed to a stress (MAST) or control task post-encoding, and 24 h later, they had to recall the material previously learned. Results indicated that the MAST increased anxiety and cortisol levels, but it did not significantly change the testosterone levels. Post-encoding MAST did not affect memory consolidation for emotional and neutral pictures. Interestingly, however, cortisol reactivity was negatively related to free recall for negative low-arousal pictures, whereas testosterone reactivity was positively related to free recall for negative-high arousal and total pictures. This study provides preliminary evidence about a different reactivity of testosterone and cortisol to the MAST as well as on their effects on consolidation. Our results suggest a different pattern of relationships between these steroid hormones and the arousal of the negative images.
Respiratory Viruses Associated With Acute Wheezing in Hospitalized Young Children in Jordan.

A cross-sectional viral surveillance study of hospitalized children less than 2 years of old in Amman, Jordan, noted that respiratory syncytial virus and human metapneumovirus, but not human rhinovirus, were associated with higher odds of acute wheezing. Future longitudinal studies are needed to evaluate the association between early childhood viral acute respiratory infections and recurrent wheezing later in childhood.
Characterizing and predicting sublethal shifts in mobility by multiple stored product insects over time to an old and novel contact insecticide in three key stored commodities.

BACKGROUND There has been a push to diversify integrated pest management (IPM) programs away from exclusive fumigant use in food facilities. Residual insecticides have been increasingly included among plans. In stored products, sublethal toxicity has been neglected in favor of evaluating direct mortality. Here, we evaluated the movement of Tribolium castaneum, Rhyzopertha dominica, Sitophilus oryzae, and Sitophilus zeamais in response to aged residues of an existing (Diacon IGR + ® with 11.4% methoprene +4.75% deltamethrin) and novel (Gravista® with 2.85% methoprene +1.2% deltamethrin +33.3% piperonyl butoxide synergist) residual insecticide. RESULTS Using the maximum labeled rate and two exposure times for each species, we assessed distance moved and velocity on wheat, rice, and corn. Assessments were made from commodity residues aged at three month intervals between 0-12 months. We found that after exposure, movement was reduced by 50-88% and equally by adults exposed to each insecticide formulation compared to untreated controls. After initial application, predicted distance moved increased from 4 m to 14 m then 28 m in a 24 h period at 3 and 12 months after application, respectively. Effectiveness of each insecticide at suppressing movement generally declined by 9-12 month after application. CONCLUSIONS Given the quick and dramatic increases in sublethal movement after initial application, our results suggest that sanitation programs in post-harvest environments are extremely important and it may be beneficial to pair chemical control with monitoring to prevent dispersal of affected insects to new areas of a facility. This article is protected by copyright. All rights reserved.
Association Between the Number of Comorbidities and the Risk of a Serious Infection in Rheumatoid Arthritis Treated by a First Biologic Agent

I n rheumatoid arthritis (RA), some comorbidities have prognostic consequences and increase the risk of infection such as age older than 50 years, a history of infection, diabetes or pulmonary disease, and treatments, notably glucocorticoids. Widdifield et al. found that rural residence, higher comorbidity with chronic lung disease or renal disease, markers of disease severity, and previous infection were associated with serious infections (SIs) in seniors with RA. Thus, it is essential to search for comorbidities in patients treated with immunosuppressant drugs because there is a 2-fold risk of infection compared with the general population. However, beyond the nature of comorbidities, we do not know the impact of the number of comorbidities on the incidence of SI.
Olive Production Threatened by a Resurgent Pest Liothrips oleae (Costa, 1857) (Thysanoptera: Phlaeothripidae) in Southern Italy

Simple Summary Liothrips oleae (Costa, 1857) (Thysanoptera: Phlaeothripidae) is widespread in the Mediterranean area, and in all regions, it is reputed to be a secondary pest in olive crops, mainly associated with damage to leaves and secondarily with damage to drupes, for which this thrips pest has a marginal impact on olive production. Taking into account the increase in the frequency of extreme damage by this species in Southern Italy in the last decade, this research aimed to elucidate the real impact (i.e., damage to leaves and drupes) by feeding thrips’ activity in olive orchards. Our results revealed that the impact of thrips was significant in all monitored olive orchards and the estimated damage level on drupes and leaves was higher in organic olive than in integrated olive management. A detailed morphological description of the Italian specimens and their molecular characterization are also provided. Abstract This study investigated a resurgence of Liothrips oleae Costa (Thysanoptera: Phlaeothripidae), an insect pest of olive crops, in a focal Southern Italian olive-producing area (Calabria Region). The young and adult olive thrips feed on the leaves and fruits of wild and cultivated olive trees, producing distortions, necrosis, and premature dropping of fruit. In our study, organic and integrated olive groves were compared for two years in order to establish the relationship between leaf and fruit damage among olive groves managed under different phytosanitary conditions. Sampling techniques were used in order to collect and count leaves and fruits (on plants and dropped premature drupes) presenting symptoms of thrips’ feeding activity. The impact of the thrips was significant in all orchards, and the estimated damage level on drupes and leaves was higher in organic olive management in each year. A morphological description of the adult females of the species is provided, and the first molecular characterization of the Calabrian olive thrips population was performed by using three different genetic regions (cytochrome c oxidase subunit I (COI), 28S ribosomal subunit (28S), and internal transcribed spacer 2 (ITS2)).
Characterization of COVID‐19 disease in pediatric oncology patients: The New York‐New Jersey regional experience

Pediatric oncology patients undergoing active chemotherapy are suspected to be at a high risk for severe disease secondary to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection; however, data to support this are lacking. We aim to describe the characteristics of coronavirus disease 2019 (COVID‐19) in this population and also its impact on pediatric cancer care in the New York region during the peak of the pandemic.
The interaction of insoluble Amyloid‐β with soluble Amyloid‐β dimers decreases Amyloid‐β plaque numbers

The heterogeneity of Amyloid‐beta (Aβ) plaque load in patients with Alzheimer's disease (AD) has puzzled neuropathology. Since brain Aβ plaque load does not correlate with cognitive decline, neurotoxic soluble Aβ oligomers have been championed as disease‐causing agents in early AD. So far, investigating molecular interactions between soluble oligomeric Aβ and insoluble Aβ in vivo has been difficult because of the abundance of Aβ oligomer species and the kinetic equilibrium in which they coexist. Here, we investigated whether Aβ plaque heterogeneity relates to interactions of different Aβ conformers.