Miracle-dz/UniFAR-FTUs huggingface dataset:
Theory of the structural glass transition: a pedagogical review

The random first-order transition theory of the structural glass transition is reviewed in a pedagogical fashion. The rigidity that emerges in crystals and glassy liquids is of the same fundamental origin. In both cases, it corresponds with a breaking of the translational symmetry; analogies with freezing transitions in spin systems can also be made. The common aspect of these seemingly distinct phenomena is a spontaneous emergence of the molecular field, a venerable and well-understood concept. In crucial distinction from periodic crystallisation, the free energy landscape of a glassy liquid is vastly degenerate, which gives rise to new length and time scales while rendering the emergence of rigidity gradual. We obviate the standard notion that to be mechanically stable a structure must be essentially unique; instead, we show that bulk degeneracy is perfectly allowed but should not exceed a certain value. The present microscopic description thus explains both crystallisation and the emergence of the landscape regime followed by vitrification in a unified, thermodynamics-rooted fashion. The article contains a self-contained exposition of the basics of the classical density functional theory and liquid theory, which are subsequently used to quantitatively estimate, without using adjustable parameters, the key attributes of glassy liquids, viz., the relaxation barriers, glass transition temperature, and cooperativity size. These results are then used to quantitatively discuss many diverse glassy phenomena, including the intrinsic connection between the excess liquid entropy and relaxation rates, the non-Arrhenius temperature dependence of α-relaxation, the dynamic heterogeneity, violations of the fluctuation-dissipation theorem, glass ageing and rejuvenation, rheological and mechanical anomalies, super-stable glasses, enhanced crystallisation near the glass transition, the excess heat capacity and phonon scattering at cryogenic temperatures, the Boson peak and plateau in thermal conductivity, and the puzzling midgap electronic states in amorphous chalcogenides.
Magnetic concentrations in stratified turbulence: the negative effective magnetic pressure instability

In the presence of strong density stratification, hydromagnetic turbulence attains qualitatively new properties: the formation of magnetic flux concentrations. We review here the theoretical foundations of this mechanism in terms of what is now called the negative effective magnetic pressure instability. We also present direct numerical simulations of forced turbulence in strongly stratified layers and discuss the qualitative and quantitative similarities with corresponding mean-field simulations. Finally, the relevance to sunspot formation is discussed.
Cognitive flexibility: neurobehavioral correlates of changing one’s mind

Abstract Behavioral and cognitive flexibility allow adaptation to a changing environment. Most tasks used to investigate flexibility require switching reactively in response to deterministic task-response rules. In daily life, flexibility often involves a volitional decision to change behavior. This can be instigated by environmental signals, but these are frequently unreliable. We report results from a novel “change your mind” task, which assesses volitional switching under uncertainty without the need for rule-based learning. Participants completed a two-alternative choice task, and following spurious feedback, were presented with the same stimulus again. Subjects had the opportunity to repeat or change their response. Forty healthy participants completed the task while undergoing a functional magnetic resonance imaging scan. Participants predominantly repeated their choice but changed more when their first response was incorrect or when the feedback was negative. Greater activations for changing were found in the inferior frontal junction, anterior insula (AI), anterior cingulate, and dorsolateral prefrontal cortex. Changing responses were also accompanied by reduced connectivity from the AI and orbitofrontal cortices to the occipital cortex. Using multivariate pattern analysis of brain activity, we predicted with 77% reliability whether participants would change their mind. These findings extend our understanding of cognitive flexibility in daily life by assessing volitional decision-making.
Pair breaking in rotating Fermi gases

We study the pair-breaking effect of rotation on a cold Fermi gas in the BCS-BEC crossover region. In the framework of BCS theory, which is supposed to be qualitatively correct at zero temperature, we find that in a trap rotating around a symmetry axis, three regions have to be distinguished: (A) a region near the rotational axis where the superfluid stays at rest and where no pairs are broken, (B) a region where the pairs are progressively broken with increasing distance from the rotational axis, resulting in an increasing rotational current, and (C) a normal-fluid region where all pairs are broken and which rotates like a rigid body. Due to region B, density and current do not exhibit any discontinuities.
Exploring stakeholders’ experiences and perceptions regarding barriers to effective surveillance of communicable diseases in a rural district of Pakistan: a qualitative study

Objective To explore the experiences and perceptions of health system stakeholders of a rural district of Sindh, Pakistan regarding the barriers to effective surveillance of communicable diseases. Design This qualitative descriptive exploratory design comprised in-depth interviews. Both inductive and deductive thematic analysis was applied to identify key themes from the data. Settings The study was conducted in public sector healthcare facilities and the district health office of the rural district of Thatta, in Sindh province, Pakistan. Participants Fifteen healthcare managers and healthcare providers working in the eight public sector primary and secondary healthcare facilities were interviewed using an open-ended in-depth interview guide. Results Key themes that emerged from the data were: poor governance and absence of surveillance policy framework; fragmentation in the health system leading to lack of uniform reporting; inadequate (human) resources that weakened the infrastructure for disease surveillance; hospital-based reporting of cases that led to a predominantly passive surveillance system; paper-based surveillance system as the key determinant of delayed reporting; non-utilisation of surveillance data for decision making; absence of local laboratory capacity to complement the detection of disease outbreaks and lack of private sector integration in disease surveillance. Conclusions Poor governance and lack of policy framework were perceived to be responsible for weak surveillance infrastructure. Resource deficiencies including inadequate human resource, paper-based reporting and the absence of local laboratory capacity were considered to result in delayed, poor quality and incomplete reporting. The lack of private sector engagement was identified as a major gap.
Extracellular vesicles metabolic changes reveals plasma signature in stage-dependent diabetic kidney disease

Abstract Objective Early diagnosis of diabetic kidney disease (DKD) has long been a complex problem. This study aimed to analyze the metabolomic characteristics of plasma extracellular vesicles (EVs) at different stages of DKD in order to evaluate the metabolites of plasma EVs and select new biomarkers for the early diagnosis of DKD. Patients and methods A total of 78 plasma samples were collected, including samples from 20 healthy controls, 20 patients with type 2 diabetes mellitus (T2DM), 18 patients with DKD stage III, and 20 patients with DKD stage IV. In addition, EVs were isolated for metabolomics analysis. Results The results identified differences in EV metabolomic characteristics in DKD patients at different stages, as well as significant differences in EV metabolomics between T2DM patients without DKD and patients with DKD. Ten Significantly differential metabolites were associated with the occurrence and progression of DKD. Uracil, LPC(O-18:1/0:0), sphingosine 1-phosphate, and 4-acetamidobutyric acid were identified as potential early biomarkers for DKD, showing excellent predictive performance. Conclusion Uracil, LPC(O-18:1/0:0), sphingosine 1-phosphate, and 4-acetamidobutyric acid exhibited potential as suitable biomarkers for early DKD diagnosis. Unexpectedly, combining these four candidate metabolites resulted in enhanced predictive ability for DKD.
Impulsivity, Sexual Compulsivity, and Sexual Risk Behaviors among Hispanic Men Who Have Sex with Men in a US–Mexico Border City

Abstract Hispanic men who have sex with men (HMSM) experience HIV risk-related and mental health disparities. The relationship of mental health (i.e., depressive symptoms and anxiety) on sexual risk behaviors of HMSM has been reported. However, little is known about the influence of impulsivity and compulsivity on sexual risk behaviors. A cross-sectional study explored these factors among 150 HMSM in the El Paso, Texas area utilizing standardized measures, in a cross-sectional study. Regression analysis determined the influence of sexual impulsivity and compulsivity, and demographic variables on sexual risk behaviors, indicating interventions should target these behaviors to mitigate sexual risk among HMSM.
Structural and vibrational investigations and molecular docking studies of a vinca alkoloid, vinorelbine

Abstract Vinorelbine, a vinca alkaloid, is an antimitotic drug that inhibits polymerisation process of tubulins to microtubules, and is widely used in cancer chemotherapy. Due to the importance of the structure-activity relationship, in this work the conformational preferences of the vinorelbine molecule were surched by PM3 method. The obtained lowest energy conformer was then optimized at DFT/B3LYP/6-31G(d,p) level of theory and the structural characteristics were determined. Frontier orbital (HOMO, LUMO) and molecular electrostatic potential (MEP) analyses were performed for the optimized structure. The experimental FT-IR, Raman and UV-VIS spectral data of vinorelbine along with the theoretical DFT/B3LYP/6-31G(d,p) calculations were investigated in detail. The vibrational wavenumbers were assigned based on the calculated potential energy distribution (PED) of the vibrational modes. To shed light into the anticancer property of vinorelbine as microtubule destabilizer, the most favourable binding mode and the interaction details between vinorelbine and tubulin were revealed by molecular docking studies of vinorelbine into the α,β-tubulin (PDB IDs: 4O2B; 1SA0; 7CNN) and binding free energies were calculated by the combination of Molecular Mechanics/Generalized Born Surface Area (MMGBSA) and Molecular Mechanics/Poisson-Boltzmann Surface Area (MM-PBSA) methods {MM/PB(GB)SA}. The calculated vinorelbine-7CNN binding free energy, using by MM/PB(GB)SA approach, was found to be the best (-50.39 kcal/mol), and followed by vinorelbine-4O2B (-28.5 kcal/mol) and vinorelbine-1SA0 (-17.59 kcal/mol) systems. Moreover, the interaction of vinorelbine with the cytochrome P450 enzymes (CYP), which are known to help in the metabolism of many drugs in the body, was investigated by docking studies against CYP2D6 and CYP3A4 targets. Communicated by Ramaswamy H. Sarma
An asymptotic expansion for a sum of modified Bessel functions with quadratic argument

We examine the sum of modified Bessel functions with argument depending quadratically on the summation index given by \[S_\nu(a)=\sum_{n\geq 1} (\frac{1}{2} an^2)^{-\nu} K_\nu(an^2)\qquad (|\arg\,a|<\pi/2)\] as the parameter $|a|\to 0$. It is shown that the positive real $a$-axis is a Stokes line, where an infinite number of increasingly subdominant exponentially small terms present in the asymptotic expansion undergo a smooth, but rapid, transition as this ray is crossed. Particular attention is devoted to the details of the expansion on the Stokes line as $a\to 0$ through positive values. Numerical results are presented to support the asymptotic theory.
Beam studies of novel THGEM-based potential sampling elements for Digital Hadron Calorimetry

Beam studies of thin single- and double-stage THGEM-based detectors are presented. Several 10 x 10 cm^2 configurations with a total thickness of 5-6 mm (excluding readout electronics), with 1 x 1 cm^2 pads inductively coupled through a resistive layer to APV-SRS readout electronics, were investigated with muons and pions. Detection efficiencies in the 98% range were recorded with an average pad-multiplicity of ~1.1. The resistive anode resulted in efficient discharge damping, with few-volt potential drops; discharge probabilities were ~10^{-7} for muons and 10^{-6} for pions in the double-stage configuration, at rates of a few kHz/cm^2. These results, together with the robustness of THGEM electrodes against spark damage and their suitability for economic production over large areas make THGEM-based detectors highly competitive compared to the other technologies considered for the SiD-DHCAL.
Immune cell profiling of preeclamptic pregnant and postpartum women by single-cell RNA sequencing

Abstract Preeclampsia (PE), a leading cause of maternal and fetal morbidity and mortality, is closely related to the immune system alterations. However, little is known about the landscape and heterogeneity of maternal immune system at single-cell level among PE patients. In this study, peripheral blood mononuclear cells (PBMCs) were isolated from three early-onset preeclamptic pregnant women and two healthy control, respectively. Single-cell RNA sequencing was performed on 10× genomics platform and single-cell transcriptomes were obtained to characterize immune cell subgroups at the pregnant and postpartum stages. In total, 80,429 single-cell transcriptomes were obtained. 19 cellular compositions were identified, which were categorized into six cell types including T cells, natural killer (NK) cells, B cells, monocytes, plasmacytoid dendritic cells and conventional dendritic cells. There were excessive activation of B cells, monocytes and NK cells in PE patients at the pregnant stage based on comparative analysis. Lower immune response activation was noticed in CD4+ and CD8+ T cells in PE patients, especially the low-activation of memory T cells at the pregnant and postpartum stages. PE patients showed high activation of B cells in pregnancy persisted postpartum and lower activation of memory T cells, indicating their persistent effects on the pathogenesis and recurrence risk of PE. This study provide a broad characterization of the single-cell transcriptome of PBMCs in PE, which contributes to identification of immune imbalance for its monitoring and treatment. PLAIN LANGUAGE SUMMARY Preeclampsia (PE) is characterized by de novo onset of proteinuria or other maternal organ dysfunction and hypertension at gestational age of 20 weeks or more. Its pathogenesis is associated with the abnormal placental development caused by insufficient trophoblast invasion and impaired spiral artery remodeling, and consequent maternal-inflammatory response and endovascular dysfunction. Peripheral immune response may play a crucial role in the pathogenesis of PE. Besides, lower activation of CD4+ memory T cells was related to the onset of PE. However, the roles of the immune cells in PE recurrence are still not well defined. Single-cell RNA sequencing was performed to immune cells in PE patients, which confirmed an excessive inflammatory state in monocytes, NK cells and B cells and lower activation of memory T cells in PE women. Our data showed that PE was associated with the immune imbalance, which may provide potential therapeutic strategies for its treatment.
SUBARU AND GEMINI OBSERVATIONS OF SS 433: NEW CONSTRAINT ON THE MASS OF THE COMPACT OBJECT

We present results of optical spectroscopic observations of the mass donor star in SS 433 with Subaru and Gemini, with an aim to best constrain the mass of the compact object. Subaru/Faint Object Camera and Spectrograph observations were performed on four nights of 2007 October 6–8 and 10, covering the orbital phase of ϕ = 0.96 − 0.26. We first calculate the cross-correlation function (CCF) of these spectra with that of the reference star HD 9233 in the wavelength range of 4740–4840 Å. This region is selected to avoid “strong” absorption lines accompanied with contaminating emission components, which most probably originate from the surroundings of the donor star, such as the wind and gas stream. The same analysis is applied to archive data of Gemini/GMOS taken at ϕ = 0.84 − 0.30 by Hillwig & Gies. From the Subaru and Gemini CCF results, the amplitude of the radial velocity curve of the donor star is determined to be 58.3 ± 3.8 km s−1 with a systemic velocity of 59.2 ± 2.5 km s−1. Together with the radial velocity curve of the compact object, we derive the mass of the donor star and compact object to be MO = 12.4 ± 1.9 M☉ and MX = 4.3 ± 0.6 M☉, respectively. We conclude, however, that these values should be taken as upper limits. From the analysis of the averaged absorption line profiles of strong lines (mostly ions) and weak lines (mostly neutrals) observed with Subaru, we find evidence for heating effects from the compact object. Using a simple model, we find that the true radial velocity amplitude of the donor star could be as low as 40 ± 5 km s−1 in order to produce the observed absorption-line profiles. Taking into account the heating of the donor star may lower the derived masses to MO = 10.4+2.3−1.9 M☉ and MX = 2.5+0.7−0.6 M☉. Our final constraint, 1.9 M☉ ⩽MX⩽ 4.9 M☉, indicates that the compact object in SS 433 is most likely a low mass black hole, although the possibility of a massive neutron star cannot be firmly excluded.
Quasiparticle tunneling in the Moore-Read fractional quantum Hall state

In fractional quantum Hall systems, quasiparticles of fractional charge can tunnel between the edges at a quantum point contact. Such tunneling (or backscattering) processes contribute to charge transport and provide information on both the charge and statistics of the quasiparticles involved. Here, we study quasiparticle tunneling in the Moore-Read state, in which quasiparticles of charges $e/4$ (non-Abelian) and $e/2$ (Abelian) may coexist and both contribute to edge transport. On a disk geometry, we calculate the matrix elements for $e/2$ and $e/4$ quasiholes to tunnel through the bulk of the Moore-Read state, in an attempt to understand their relative importance. We find that the tunneling amplitude for charge $e/2$ quasihole is exponentially smaller than that for charge $e/4$ quasihole, and the ratio between them can be (partially) attributed to their charge difference. We find that including long-range Coulomb interaction only has a weak effect on the ratio. We discuss briefly the relevance of these results to recent tunneling and interferometry experiments at filling factor $\ensuremath{\nu}=5/2$.
The dominance of quenching through cosmic times

The evolution with cosmic time of the star formation rate density (SFRD) and of the "Main Sequence" star formation rate-stellar mass relations are two well established observational facts. In this paper the implications of these two relations combined are analytically explored, showing that quenching of star formation must start already at very early cosmic times and the quenched fraction then dominates ever since over the star forming one. Thus, a simple picture of the cosmic evolution of the global SFRD is derived, in terms of the interplay between star formation and its quenching.
The ESO UVES advanced data products quasar sample – III. Evidence of bimodality in the [N/α] distribution

We report here a study of nitrogen and α-capture element (O, S, and Si) abundances in 18 Damped Lyα Absorbers (DLAs) and sub-DLAs drawn from the ESO-UVES Advanced Data Products (EUADP) database. We report 9 new measurements, 5 upper and 4 lower limits of nitrogen that when compiled with available nitrogen measurements from the literature makes a sample of 108 systems. The extended sample presented here confirms the [N/α] bimodal behaviour suggested in previous studies. Three-quarter of the systems show h[N/α]i= −0.85 (±0.20dex) and one-quarter ratios are clustered at h[N/α]i = −1.41 (±0.14dex). The high [N/α] plateau is consistent with the H ii regions of dwarf irregular and blue compact dwarf galaxies although extended to lower metallicities and could be interpreted as the result of a primary nitrogen production by intermediate mass stars. The low [N/α] values are the lowest ever observed in any astrophysical site. In spite of this fact, even lower values could be measured with the present instrumentation, but we do not find them below [N/α] ≈ −1.7. This suggests the presence of a floor in [N/α] abundances, which along with the lockstep increase of N and Si may indicate a primary nitrogen production from fast rotating, massive stars in relatively young or unevolved systems.
On the stability of some isoperimetric inequalities for the fundamental tones of free plates

We provide a quantitative version of the isoperimetric inequality for the fundamental tone of a biharmonic Neumann problem. Such an inequality has been recently established by Chasman adapting Weinberger's argument for the corresponding second order problem. Following a scheme introduced by Brasco and Pratelli for the second order case, we prove that a similar quantitative inequality holds also for the biharmonic operator. We also prove the sharpness of both such an inequality and the corresponding one for the biharmonic Steklov problem.
Post cardiac arrest physical exercise mitigates cell death in the septal and thalamic nuclei and ameliorates contextual fear conditioning deficits in rats

A major concern for cardiac arrest (CA) survivors is the manifestation of long-term cognitive impairments. Physical exercise (PE) is a well-established approach to improve cognitive functions under certain pathological conditions. We previously showed that PE post-CA mitigates cognitive deficits, but the underlying mechanisms remain unknown. To define neuroprotective mechanisms, we analyzed whether PE post-CA protects neurons involved in memory. We first performed a contextual fear conditioning (CFC) test to confirm that PE post-CA preserves memory in rats. We then conducted a cell-count analysis and determined the number of live cells in the hippocampus, and septal and thalamic nuclei, all areas involved in cognitive functions. Lastly, we performed RNA-seq to determine PE post-CA effect on gene expression. Following CA, exercised rats had preserved CFC memory than sham PE animals. Despite this outcome, PE post-CA did not protect hippocampal cells from dying. However, PE ameliorated cell death in septal and thalamic nuclei compared to sham PE animals, suggesting that these nuclei are crucial in mitigating cognitive decline post-CA. Interestingly, PE affected regulation of genes related to neuroinflammation, plasticity, and cell death. These findings reveal potential mechanisms whereby PE post-CA preserves cognitive functions by protecting septal and thalamic cells via gene regulation.