Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Celecoxib and Infliximab against Multiple Organ Damage Induced by Sepsis in Rats: A Comparative Study

In cases of sepsis, the immune system responds with an uncontrolled release of proinflammatory cytokines and reactive oxygen species. The lungs, kidneys, and liver are among the early impacted organs during sepsis and are a direct cause of mortality. The aim of this study was to compare the effects of infliximab (IFX) and celecoxib (CLX) on septic rats that went through a cecal ligation and puncture (CLP) surgery to induce sepsis. This study included four groups: sham, CLP (untreated), and CLP-treated with CLX or IFX. The administration of “low dose” CLX or IFX was performed after 2 h following the induction of sepsis. Twenty-four hours following the induction of sepsis, the rats were sacrificed and blood samples were collected to evaluate kidney, liver, and lung injuries. MDA and NOx content, in addition to SOD activity and GSH levels, were evaluated in the tissue homogenates of each group. Tissue samples were also investigated histopathologically. In a separate experiment, the same groups were employed to evaluate the survival of septic rats in a 7-day observation period. The results of this study showed that treatment with either CLX or IFX ameliorated the three organs’ damage compared to septic-untreated rats, decreased oxidative stress, enhanced the antioxidant defense, and reduced serum cytokines. As a result, a higher survival rate resulted: 62.5% and 37.5% after the administration of CLX and IFX, respectively, compared to 0% in the CLP group after 7 days. No significant differences were observed between the two agents in all measured parameters. Histopathological examination confirmed the observed results. In conclusion, CLX and IFX ameliorated lung, kidney, and liver injuries associated with sepsis through anti-inflammatory and antioxidant actions, which correlated to the increase in survival observed with both of them.
Management of Competitiveness in the EU Member States: The Main Strengths and Weaknesses

The paper's main objective is to investigate the differences in competitiveness among the EU member states. Each nation's competitiveness is determined by its government's management capabilities on the national, regional and local levels and thus poses substantial implications to economic growth. For this purpose, hierarchical clustering as the primary method of investigation was selected. The data mining process was based on extracting GCI score data about individual member states. Based on the GCI score evaluation, the cluster analysis showed two groups of EU member states, according to the 'traditional' division of old member states (OMS) and new member states (NMS). Results showed a statistically significant gap in GCI scores between the OMS and NMS. Furthermore, the within-class variability in the OMS cluster appears to be higher than in the NMS cluster, which underlines growing disparities among old member states. Most significant differences among both groups prevail in the field of institutions, ICT adoption, business dynamism and innovation. Finally, the link between achieved GCI score and average economic growth has been investigated. Contrary to expectations, more developed member states (OMS) showed, on average, relatively lower economic growth rates over the investigated period than the less developed member states (NMS). The results showed a moderately negative link between the GCI score and economic growth, which suggests that a higher GCI score does not mean achieving higher economic growth, whereas member states with lower total GCI scores could outpace the higher ones in terms of economic growth. In many aspects, the EU still resembles two rails in Europe, and a significant gap between OMS and NMS prevails. Relatively higher economic growth of NMS might help reduce the gap over time. However, it may prove a short-sighted, and significant lags in many crucial factors will stiff the competitiveness in the long term.
Integration or exclusion? Assimilation of non-Irish nationals into the Irish labour market

ABSTRACT Using data based on the national Labour Force Survey, we examine the extent to which immigrants coming to Ireland over a twenty-year period from 1998 to 2019 have assimilated into the labour market based on occupational level, education, employment sector, union membership and rates of unemployment. Overall, immigrants enjoyed conditions in the labour market in 1998 at least as good, if not better than, nationals and appeared to be relatively well assimilated. In contrast, immigrants by 2019 were at a disadvantage compared to nationals, indicating reduced levels of assimilation. A plausible explanation for these trends is the shift away from immigrants mainly from the UK and EU15 in 1998 who had similar cultural (and linguistic) and racial/ethnic characteristics, and a move towards immigrants originating mainly from Eastern European countries and the rest of the world in 2019. However, our results show that immigrants from Eastern European countries were the least assimilated group despite their European origin and cultural compatibility with native Irish.
Annelerin doğum sonu konforunu etkileyen faktörler

Amac: Konfor kavrami; âbireyin gereksinimleri ile ilgili yardim, huzur saglama ve sorunlarin ustesinden gelebilmeye iliskin fiziksel, psikolojik, sosyal ve cevresel butunluk icerisinde kompleks yapiya sahip beklenen bir sonucâ olarak tanimlamaktadir. Bu calisma, annelerin dogum sonu konforu ve etkileyen faktorlerin belirlenmesi amaciyla planlandi. Gerec ve Yontem: Calisma, kesitsel ve tanimlayici olarak planlanmistir. Arastirmanin evrenini 30.07. 2008 ve 31.12. 2008 tarihleri arasinda Baskent Universitesi Ankara Hastanesi Dogum Servisine basvuran anneler olusturmustur (n=150). Verilerin toplanmasinda anket formu ve dogum sonu konfor olcegi kullanilmistir. Bulgular: Annelerin yas ortalamasi 26.4 ± 3.5 yil olup, cogunlugunu lise mezunu (%68.7) ve multipar (%66.0) kadinlar olusturmaktaydi. Annelerin dogum sonu donemde halsizlik, agri, ayaga kalkmada gucluk, kisisel hijyenini yerine getirememe, bebek bakimina yonelik bilgi eksikligi ve deneyimsizlik gibi konularda sorun yasadiklari belirlendi. Normal dogum yapan annelerin konfor puanlarinin sezaryen olanlara gore daha yuksek oldugu goruldu (p
Single-Centre Retrospective Evaluation of Intraoperative Hemoadsorption in Left-Sided Acute Infective Endocarditis

Background: Cardiac surgery in patients with infective endocarditis (IE) is still associated with high mortality and morbidity; an already present inflammation might further be aggravated due to a cardiopulmonary bypass-induced dysregulated immune response. Intraoperative hemoadsorption therapy may attenuate this septic response. Our objective was therefore to assess the efficacy of intraoperative hemoadsorption in active left-sided native- and prosthetic infective endocarditis. Methods: Consecutive high-risk patients with active left-sided infective endocarditis were enrolled between January 2015 and April 2021. Patients with intraoperative hemoadsorption (Cytosorbents, Princeton, NJ, USA) were compared to patients without hemoadsorption (control). Endpoints were the incidence of postoperative sepsis, sepsis-associated death and in-hospital mortality. Predictors for sepsis-associated mortality and in-hospital mortality were analysed by multivariable logistic regression. Results: A total of 202 patients were included, 135 with active left-sided native and 67 with prosthetic valve infective endocarditis. Ninety-nine patients received intraoperative hemoadsorption and 103 patients did not. Ninety-nine propensity-matched pairs were selected for final analyses. Postoperative sepsis and sepsis-related mortality was reduced in the hemoadsorption group (22.2% vs. 39.4%, p = 0.014 and 8.1% vs. 22.2%, p = 0.01, respectively). In-hospital mortality tended to be lower in the hemoadsorption group (14.1% vs. 26.3%, p = 0.052). Key predictors for sepsis-associated mortality and in-hospital mortality were preoperative inotropic support, lactate-levels 24 h after surgery, C-reactive protein levels on postoperative day 1, chest tube output, cumulative inotropes and white blood cell counts on postoperative day 2, and new onset of dialysis. Multivariate regression analysis revealed intraoperative hemoadsorption to be associated with lower sepsis-associated (OR 0.09, 95% CI 0.013–0.62, p = 0.014) as well as in-hospital mortality (OR 0.069, 95% CI 0.006–0.795, p = 0.032). Conclusions: Intraoperative hemoadsorption holds promise to reduce sepsis and sepsis-associated mortality after cardiac surgery for active left-sided native and prosthetic valve infective endocarditis.
How gender moderates the mediating mechanism across social experience, self-referent beliefs and social entrepreneurship intentions

Purpose This study aims to understand how social experience influences social entrepreneurial (SE) intentions through different types of self-referent beliefs and how gender affects this mechanism. Design/methodology/approach To test this study’s conceptual model, the authors conducted an online survey and recruited respondents via Amazon’s Mechanical Turk. This study’s analysis is based on 743 responses. This study used structural equation modeling to test the main hypotheses, conducted decomposition tests using the bootstrapping method to test mediation effects via self-referent beliefs and executed multi-group analyses to examine gender-moderated mediation effects. Findings The results confirm that social experience significantly influences all three types of self-referent beliefs (entrepreneurial self-efficacy, SE self-efficacy and self-esteem). Furthermore, the mediating relationship across social experience, self-efficacies, and SE intentions is moderated by gender, as the relationships between social experience and self-efficacies are stronger for women than for men. Originality/value A clear gender gap exists in the way how social experience affects perceptual variables (self-referent beliefs), providing a practical suggestion to reduce the perceptual gender gap in social entrepreneurial contexts. This study also reveals the mediating mechanism across social experience, self-efficacies and SE intentions, also highlighting the importance of domain specific self-efficacies. This study’s findings support and extend Milliken’s (1987) framing of three distinct types of uncertainty to explain how individuals form SE intentions.
Genome-Wide Association Study of Nucleotide Variants Associated with Resistance to Nine Antimicrobials in Mycoplasma bovis

Antimicrobial resistance (AMR) studies of Mycoplasma bovis have generally focused on specific loci versus using a genome-wide association study (GWAS) approach. A GWAS approach, using two different models, was applied to 194 Mycoplasma bovis genomes. Both a fixed effects linear model (FEM) and a linear mixed model (LMM) identified associations between nucleotide variants (NVs) and antimicrobial susceptibility testing (AST) phenotypes. The AMR phenotypes represented fluoroquinolones, tetracyclines, phenicols, and macrolides. Both models identified known and novel NVs associated (Bonferroni adjusted p < 0.05) with AMR. Fluoroquinolone resistance was associated with multiple NVs, including previously identified mutations in gyrA and parC. NVs in the 30S ribosomal protein 16S were associated with tetracycline resistance, whereas NVs in 5S rRNA, 23S rRNA, and 50S ribosomal proteins were associated with phenicol and macrolide resistance. For all antimicrobial classes, resistance was associated with NVs in genes coding for ABC transporters and other membrane proteins, tRNA-ligases, peptidases, and transposases, suggesting a NV-based multifactorial model of AMR in M. bovis. This study was the largest collection of North American M. bovis isolates used with a GWAS for the sole purpose of identifying novel and non-antimicrobial-target NVs associated with AMR.
Irrigation characterization improved by the direct use of SMAP soil moisture anomalies within a data assimilation system

Prior soil moisture data assimilation (DA) efforts to incorporate human management features such as agricultural irrigation has only shown limited success. This is partly due to the fact that observational rescaling approaches for bias correction used in soil moisture DA systems are less effective when unmodeled processes such as irrigation are the dominant source of systematic biases. In this article, we demonstrate an alternative approach, i.e. anomaly correction for overcoming this limitation. Unlike the rescaling approaches, the proposed method does not scale remote sensing soil moisture retrievals to the model climatology, but it extracts the temporal variability information from the retrievals. The study demonstrates this approach through the assimilation of soil moisture retrievals from the Soil Moisture Active Passive mission into the Noah land surface model. The results demonstrate that DA using the anomaly correction method can better capture the effect of irrigation on soil moisture in agricultural areas while providing comparable performance to the DA integrations using rescaling approaches in non-irrigated areas. These findings emphasize the need to reduce inconsistencies between remote sensing and the models so that assimilation methods can employ information from remote sensing more directly to develop representations of unmodeled processes such as irrigation.
Analysis of Observed Trends in Daily Temperature and Precipitation Extremes in Different Agroecologies of Gurage Zone, Southern Ethiopia

Ethiopian climate-sensitive economy is particularly vulnerable to the effects of climate-related extreme events. Thus, examining extreme daily precipitation and temperature in the context of climate change is a critical factor in advocating climate change adaptation at the local scales. Spatial changes of climate indices for extreme precipitation and temperatures were conducted for the period 1986–2016 in three different agroecologies of the Gurage zone, Southern Ethiopia. The study used the Mann–Kendall (MK) test and Sen’s slope estimator to estimate the trend and magnitude of changes in precipitation and temperature. The analysis from the observation indicates that there had been a consistent warming trend and inconsistent changes in precipitation extremes in the study agroecologies. A statistically significant increase in the numbers of warm days and nights and a statistically significant reduction in the numbers of cold days and nights were observed in most of the agroecologies. The duration of extreme trend showed inconsistency; however, a drier condition is observed in lowland agroecology. Therefore, based on the findings of this study, appropriate climate adaptation efforts are needed at the local scale.
Development of Moist Singular Vectors in GRAPES-GEPS and a Preliminary Evaluation

ABSTRACT In this study, moist singular vector (MSV) was developed based on GRAPES-GEPS (Global/Regional Assimilation and Prediction System – Global Ensemble Prediction System), the adjoint model of large-scale condensation and cumulus deep convection in GRAPES-4DVar (Four-dimensional variational assimilation). Five consecutive days of numerical experiments were performed for a preliminary evaluation of MSV. The singular values, horizontal distribution structure, spread of MSVs perturbation and its influence on the ensemble prediction were compared for each group of tests. The results showed that in the middle and high latitudes of the northern and southern hemispheres, the addition of both linearized moist physical processes increased the spread of the mid- and low-level SVs, but the linearized large-scale condensation (LC) process plays a leading role in the structure of MSV. The analysis of ensemble forecast shows the inclusion of moist linearized physical processes led to a greater effect of MSV on the rainfall levels of 10 and 25 mm and a slight improvement in anomaly correlation coefficient (ACC) of the atmospheric circulation field, and more obvious improvement due to linearized large-scale condensation. In the future, continuous multi-year testing and tropical-specific analyses are required for operation.
A Generalized Recursive Vogler Algorithm for Multiple Bridged Knife-Edge Diffraction

In this article, we consider the problem of estimating diffraction attenuation from the approximation of terrain using a multiple bridged knife-edge model. This model can be considered as a generalization of the well-known multiple knife-edge (MKE) one where spaces between knife-edges are bridged by reflecting surfaces. A series-based-standard solution is presented in the literature but suffers from its very high computational complexity. We, thus, propose to generalize the recursive Vogler algorithm developed for the MKE model to tackle this problem. To reduce complexity, the proposed algorithm exploits the recursive form to avoid repeated calculations of the existing solution. Moreover, we provide a complexity analysis of both the standard algorithm and the proposed algorithm based on the number of computed integrals. Both theoretical and numerical results show that our proposed algorithm is faster than the original one while having identical accuracy, hence proving the effectiveness of our solution.
Ascitic Senescent T Cells Are Linked to Chemoresistance in Patients With Advanced High-Grade Serous Ovarian Cancer

Senescent T cells are reported to be increased in patients with cancer and are poor prognostic indicators. However, the distribution of senescent T cells and their correlation with clinical features in high-grade serous ovarian cancer (HGSOC) is unknown. We detected the percentage of senescent T cells in the peripheral blood and ascites of patients with advanced HGSOC (n = 86) at diagnosis by flow cytometry. Compared with healthy donors, patients with HGSOC exhibited an accumulation of CD28−CD57+ (Tsen) CD8+ T cells in the peripheral blood and ascites. The frequency of Tsen CD8+ T cells in the peripheral blood was positively correlated with age and pretreatment serum CA125 and increased in patients with large volume ascites, whereas the frequency of Tsen CD8+ T cells in ascites was elevated in patients with lymph node metastasis. Patients with Tsen-high in ascites (>19.92%), but not in the peripheral blood, were more likely to be resistant to chemotherapy and had shorter progression-free survival. Tsen CD8+ T cells exhibited common senescence features including increased SA-β-gal activity, declines in proliferation, loss of CD27 and gain of KLRG-1, and the production of cytokines. In ascites, the percentage of Tsen CD8+ T cells was positively correlated with levels of interleukin-10 and granzyme B. This study suggests the potential of ascitic Tsen CD8+ T cells at diagnosis as a prognostic biomarker in HGSOC.
The Effect of Ambassador's Brand, and Brand Image on Purchase Decision Process in E-Commerce Tokopedia

The purpose of this study is to discover and explain the effects of Brand Ambassador and Brand Image on the Purchase Decision Process, as well as to discover and explain that the Brand Ambassador variable has a partial effect on the Purchase Decision Process. An explanatory research type and a quantitative approach are used in this study. A total of three variables were examined in this research: Brand Ambassadors (X1), Brand Image (X2), and the Purchase Decision Process (PDP) (Y). Tokopedia customers were asked to fill out an online survey as a means of obtaining data. The sample used in this study amounted to 116 respondents with the respondent's criteria, namely respondents knew E-Commerce Tokopedia and had shopped online through E-Commerce Tokopedia. Descriptive and multiple linear regression analysis are utilized as sampling methods. The results demonstrated that the purchase decision process (Y) was highly influenced by both the Brand Ambassador (X1) and Brand Image (X2) variables at the same time. Then, the influence of Brand Ambassador (X1) and Brand Image (X2) variables on the Purchase Decision Process is partial and significant (Y).
HUMANISING MOBILE ONLINE ESL BLENDED LEARNING MODEL

Background and Purpose: The COVID-19 pandemic has given a massive proliferation of technology, particularly in education, redefining language learning from face-to-face (F2F) and off-classroom known as blended learning (BL) to a new kind in online distance learning/education (ODL/E). BL is now a mix of synchronous and asynchronous learning. The shift, however impressive it may appear, does not guarantee the effectiveness of the learning process. The gap that leads to the current study is how bibliometrics has shown minimal focus on undergraduates’ acceptance of these changes, especially in English as a Second Language (ESL) learning classes to the newly embraced online BL (OBL) and how humanistic values are important in ESL lessons. Thus the study sets out to understand several issues pertaining to the use of mobile communication devices as a learning tool in ESL MoBL. Methodology: The present study is a mixed-method research approach using a sequential exploratory design. A set of Technology Acceptance Model (TAM) questionnaires was distributed to understand 264 teacher-trainers, degree and diploma students’ inclination towards ESL mobile learning platforms after a semester of mobile open blended learning (MoBL) integration, whilst side-lining the unnecessary information of Unified Theory of Acceptance and Use of Technology (UTAUT2). Interviews based on Analysis, Design, Assess, and Belief (ADAB) Model further enriched the data on the humanisation aspects of MoBL. Findings: Findings showed that learners’ inclination to the new MoBL can be affected by gender, age, and maturity. Thus to implement a more humanistic learning modification demands a thorough understanding of students’ needs. Contributions: The novelty of these findings is the sampling contrasting both degree and diploma students along with teacher-trainees’ perceptions of humanistic values in OBL highlights the effects of, age, maturity and gender on technology in education. This paper suggests a discussion on the humanistic MoBL model for ESL learners. The future implication of the findings suggests age, maturity, and gender affect students’ inclination towards the new MoBL, and pushes the need for more humanistic essences in MoBL. Keywords: Education, ESL and ELT, humanistic values, mobile learning model, online blended learning, and open distance learning. Cite as: Tengku Intan Suzila, T. S. , Mohd Yusri, M. N. , Omar, S. R. , & Teo, K. S. (2022). Humanizing mobile online ESL blended learning model. Journal of Nusantara Studies, 7(2), 473-494. http://dx.doi. org/10.24200/jonus.vol7iss2pp473-494
Lean and corporate social responsibility: a systematic literature review

Companies have been adopting corporate social responsibility (CSR) practices to improve their competitiveness and performance. Lean production has been found to be able to boost green and other dimensions of CSR such as health and safety and social responsibility, and there is ever-growing research interest in lean and CSR. The primary purpose of this study is to analyze the current literature related to lean production and CSR, and to propose new avenues of research in this area. Thus, the study employed a systematic literature review approach. Hundred and twenty-one articles were selected, reviewed, and synthesized. The search included all years included in the databases until 2020. It was found that research has generally investigated lean and the environmental dimension of CSR, but only a limited amount of research has examined lean in relation to other CSR dimensions or directly to CSR as a whole. Research has particularly lacked in relation to lean performance, stakeholders, and the effects of lean on CSR at a more complex level. The findings reveal a relatively high degree of compatibility between lean, its tools and methods, and CSR, particularly the environmental and safety dimensions of CSR.