Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase II study of refametinib (BAY 86-9766), an allosteric dual MEK 1/2 inhibitor, and gemcitabine in patients with unresectable, locally advanced, or metastatic pancreatic cancer.

4025 Background: Refametinib is a potent oral allosteric MEK 1/2 inhibitor with single-agent and synergistic activities in combination with gemcitabine in preclinical pancreatic cancer (PC) models. We report the results of a single-arm, open-label, phase 2a study combining refametinib and gemcitabine in advanced PC. Methods: Eligibility criteria included: ECOG PS ≤ 2; locally advanced, unresectable or metastatic pancreatic adenocarcinoma; and no prior systemic therapy. Refametinib was administered 50 mg bid po in combination with gemcitabine (1000 mg/m2 IV weekly for 7 of 8 weeks in C1; 3 of 4 weeks in subsequent cycles). The primary objective was overall response rate (ORR); secondary objectives were duration of response (DOR), disease control rate (DCR), time to progression (TTP), progression-free survival (PFS), overall survival (OS) and safety. All responses were confirmed by central independent radiological review. Genetic biomarker analysis was conducted on circulating tumor DNA from plasma samples .
THE INCIDENCE OF PERFORATED APPENDICITIS AMONG PEDIATRIC PATIENTS IN KHARTOUM NORTH TEACHING HOSPITAL, SUDAN

Introduction: Acute appendicitis is a common emergency condition in paediatrics with different ages. The perforated appendicitis is one of the most serious complications of acute appendicitis which may lead to peritonitis. The aim of our study is to calculate the incidence of perforated appendicitis. Methods: This is a retrospective cross-sectional study has been conducted at Khartoum north teaching hospital. The total number of patients was 214. Results: the most common age in this study are 13 years old and the mean age is 11 years, 128 of cases were male 59.8% and 86 were females 40.2%. All cases of our study presented with fever 100%, 80.8% presented with right iliac fossa pain, and anorexia 100%. 50.5% of cases came within the first day of presentation and 26.6% of cases came in 4thday of presentation, all cases presented with right iliac fossa tenderness, 15.9% of cases presented with perforated acute appendicitis, 67.29% of cases operated after 6 hours, 5.61% operated in more than 6 hours and 27.1% operated after 6 weeks. Conclusion: In this study the incidence of perforated acute appendicitis was 15.9% which is low in comparison with another study because there was no delay in appendectomy operation and the majority of patients came within the first day of the disease.
Inferring efficient operating rules in multireservoir water resource systems: A review

Coordinated and efficient operation of water resource systems becomes essential to deal with growing demands and uncertain resources in water‐stressed regions. System analysis models and tools help address the complexities of multireservoir systems when defining operating rules. This paper reviews the state of the art in developing operating rules for multireservoir water resource systems, focusing on efficient system operation. This review focuses on how optimal operating rules can be derived and represented. Advantages and drawbacks of each approach are discussed. Major approaches to derive optimal operating rules include direct optimization of reservoir operation, embedding conditional operating rules in simulation‐optimization frameworks, and inferring rules from optimization results. Suggestions on which approach to use depend on context. Parametrization–simulation–optimization or rule inference using heuristics are promising approaches. Increased forecasting capabilities will further benefit the use of model predictive control algorithms to improve system operation.
Determination of road profile using multiple passing vehicle measurements

Abstract This paper describes a novel method to determine a road profile through the analysis of accelerations in a passing vehicle. A direct integration algorithm is proposed to determine the profile from the measured vehicle acceleration response. A sprung mass model and a half-car model are used to represent the vehicles in separate analyses. Combining the direct integration algorithm with the Cross Entropy (CE) optimisation method, a vehicle fleet monitoring concept is proposed for the monitoring of roads and/or bridges. In this approach, the profile can be calculated using accelerations from multiple vehicles without prior knowledge of the vehicle properties. Numerical results show that calculated profiles are the same as the ‘true’ profiles which were used to generate the ‘simulated measured’ accelerations.
RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila

How to respond to starvation determines fitness. One prominent behavioral response is increased locomotor activities upon starvation, also known as Starvation-Induced Hyperactivity (SIH). SIH is paradoxical as it promotes food seeking but also increases energy expenditure. Despite its importance in regulating fitness, the genetic contributions to SIH as a behavioral trait remains unexplored. Here, we examined SIH in the Drosophila melanogaster Genetic Reference Panel (DGRP) and performed genome-wide association studies. We identified 23 significant loci, corresponding to 14 genes, significantly associated with SIH in adult Drosophila. Gene enrichment analyses indicated that genes encoding ion channels and mRNA binding proteins (RBPs) were most enriched in SIH. We are especially interested in RBPs because they provide a potential mechanism to quickly change protein expression in response to environmental challenges. Using RNA interference, we validated the role of Syp in regulating SIH. Syp encodes Syncrip, an RBP. While ubiquitous knockdown of Syp led to lethality during development, adult flies with neuron specific Syp knockdown were viable and exhibited decreased SIH. Using the Temporal and Regional Gene Expression Targeting (TARGET) system, we further confirmed the role of Syp in adult neurons in regulating SIH. Lastly, RNA-seq analyses revealed that Syp was alternatively spliced under starvation while its expression level was unchanged. Together, this study not only demonstrates genetic contributions to SIH as an important behavioral trait but also highlights the significance of RBPs and post-transcriptional processes in the brain in regulating behavioral responses to starvation. Author summary Animals living in the wild often face periods of starvation. How to physiologically and behaviorally respond to starvation is essential for survival. One behavioral response is Starvation-Induced Hyperactivity (SIH). We used the Drosophila melanogaster Genetic Reference Panel, derived from a wild population, to study the genetic basis of SIH. Our results show that there is a significant genetic contribution to SIH in this natural population, and that RNA binding proteins (RBPs) are especially important. Using RNA interference and the TARGET system, we confirmed the role of an RBP Syp in adult neurons in SIH. Further studies using RNA-seq and Western blotting showed that Syp was alternatively spliced under starvation while its expression level was unchanged, highlighting an essential role of post-transcriptional modification.
Entrepreneurship Education through Successful Entrepreneurial Models in Higher Education Institutions

In higher education institutions, entrepreneurship learning based on successful entrepreneurial role models may promote education for sustainable development. Several theoretical perspectives, such as the human capital theory, the entrepreneurial self-efficacy and self-determination theory, argue that entrepreneurship education is positively correlated with entrepreneurial intentions of students, as it provides adequate know-how and skills and motivates them to develop their entrepreneurial careers. In entrepreneurship education programmes, exposure to successful entrepreneurial models could be a significant factor for stimulating students’ confidence in their ability to start a business and for improving their attitudes towards entrepreneurship. This study aims (i) to identify characteristics viewed by students as being specific to a successful entrepreneur, (ii) to establish the influence of exposure to successful entrepreneurial role models (chosen by students) during entrepreneurship education classes on student entrepreneurial intentions, and (iii) to assess how such exposure influences the attitudes of students towards entrepreneurship. For this purpose, the authors ran a pilot experiment with 30 graduate students enrolled in a Business Creation course using a research methodology that combined qualitative techniques with quantitative measures. Content and statistical analyses were utilised to examine differences in student entrepreneurial intentions and attitudes towards entrepreneurship after being exposed to successful entrepreneurial models. Our study provides evidence that entrepreneurship education based on successful entrepreneurial role models may positively influence the entrepreneurial attitudes and intentions of students and could lead to higher orientation of student perception towards social benefits of entrepreneurship (new jobs) compared to financial ones (high income). However, our findings stress that if educators want to improve the efficiency of education focused on developing entrepreneurial skills, graduate programmes should be designed differently for business and non-business students, since studying successful entrepreneurial stories impacts these two groups differently.
Nonlinear Impacts of Surface Exchange Coefficient Uncertainty on Tropical Cyclone Intensity and Air‐Sea Interactions

Tropical cyclone maximum intensity is believed to result from a balance between the surface friction, which removes energy, and a temperature/moisture (enthalpy) difference between the sea surface and the air above it, which adds energy. The competing processes near the air‐sea interface are controlled by both the near surface wind speed and the surface momentum (Cd) and enthalpy (Ck) exchange coefficients. Unfortunately, these coefficients are currently highly uncertain at high wind speeds. Tropical cyclone winds also apply a force on the ocean surface, which results in ocean surface cooling through vertical mixing. Using coupled atmosphere‐ocean and uncoupled (atmosphere only) ensemble simulations we explore the complex influence of uncertain surface exchange coefficients on storm‐induced ocean feedback and tropical cyclone intensity. We find that the magnitude of ocean cooling increases with storm intensity and Cd. Additionally, the simulated maximum wind speed uncertainty does not necessarily decrease when ocean feedback are considered.
The Role of Emotional Distress in Predicting Opiate Analgesic Medication Use in Chronic Pain Patients

Chronic pain is a common, costly, and debilitating problem. The biopsychosocial model purports that biological, psychological, and social factors are involved in the experience of chronic pain. Multidisciplinary pain management programs adhere to the biopsychosocial model and successfully treat and manage chronic pain. Depression, anxiety, and opiate analgesic medication misuse and abuse are significant problems faced by many individuals with chronic pain, however these relationships are not well understood. This study examined a sample of 248 chronic pain patients who completed a multidisciplinary pain management program. Two hypotheses were tested. First, it was hypothesized that the relationships amongst change in pain, pain-related anxiety, depression, and change in opiate analgesic medication use would be significantly correlated. Second, it was predicted that change in emotional distress would mediate the relationship between change in pain and change in opiate analgesic medication use. Structural equation modeling and residualized change scores were used to examine the hypothesized relationships. Participants ranged from 24 to 81-years-old (M = 44.4, SD = 9.67), 65% of the participants were male, and they were primarily Caucasian (86.0%). The first hypothesis was largely supported, as there were significant correlations among change in pain and change in anxiety (r = .202), change in pain and change in depression (r = .310), change in anxiety and change in depression (r = .587), change in opioid use and change in anxiety (r = .188), and change in opioid use and change in depression (r = .178) . The second hypothesis was also supported, as change in emotional distress indirectly affected the relationship between change in pain and change in opiate analgesic Emotional Distress and Opioid Use in CP Patients vii medication use (β = .050; 95% CI = .017 to .099, p = .003). Our findings suggest that emotional distress is a critical variable to address not only when treating chronic pain but also when working with patients with problematic opioid use. These findings have important treatment implications, and suggest that interventions focusing on treating emotional distress may help decrease problems associated with opioid use. Emotional Distress and Opioid Use in CP Patients 8 A. CHAPTER I: Introduction and Literature Review
Perceptions of Licensed Pharmacist Managers regarding Formally Versus Informally Trained Pharmacy Technicians

Perceptions of Licensed Pharmacist Managers regarding Formally Versus Informally Trained Pharmacy Technicians by Shalonica Cluse MA, Texas Southern University, 2006 BS, Texas Southern University, 2003 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Health Walden University August 2016
Are Enteral Intakes of Protein, Lipid, Carbohydrate, Energy, Calcium, and Phosphorus in VLBW Preterm Infants Meeting Current Expert Recommendations?

Research evidence supports the importance of nutrition to facilitate growth, reduce morbidity and enhance the neurodevelopment in very low birth weight (VLBW) infants. Local neonatal intensive care units have adopted more aggressive feeding guidelines to achieve nutrient goals. This study aims to examine the impact of major morbidity and birth weight (BW) on achieving expert nutrient recommendations in a cohort of VLBW preterm infants during initial hospitalization. Infants with ≥ 1 major morbidity/BW <1000g were less likely than their healthy/ BW 1000-1499g counterparts, to achieve recommendations, with 53%, 45%, 46%, 48%, 45%, and 47%/53%, 44%, 45%, 49%, 45%, and 48% , vs. 33%, 25%, 34%, 38%, 32%, and 26%/36%, 28%, 38%, 39%, 33%, and 28%, respectively, failing to achieve minimum requirements for protein, lipid, carbohydrate, energy, calcium, and phosphorus. Discussion and further research is needed to identify obstacles and develop strategies to completely eradicate this deficit in nutrient delivery.
Career Preferences of Male and Female Higher Secondary Students – A Comparative study

The present investigation intended to study the career preferences of male and female higher secondary students. The study was conducted on a sample of 200 higher secondary students (N= 100 males & 100 females) studying in 12 th class in various government Higher secondary institutes of district Budgam. The sample was drawn on random basis. Bhargava and Bhargava’s career preference record were used to collect data from the selected sample. Percentage statistics were used to analyses the data collected. The study revealed that the male and female higher secondary students differ with respect to their career preference.
Effect of Transformational Leadership of a Principal’s Management Ability on the Work Motivation of Teachers to Provide Guidance and Counseling at Senior High Schools in Medan, Indonesia

This aim of this study was to determine the effect of transformational leadership of the principal and the principal’s management ability on the work motivation of teachers towards providing guidance and counseling at senior high schools in Medan, Indonesia. In addition, the study sought to find out which is greater, the effect of transformational leadership of the principal, or the ability to motivate teachers to provide guidance and counseling. The sample in this research were 148 teachers who provide guidance and counseling. This research study was descriptive percentage. The results show that the effect of transformational leadership of the principal on the motivation of teachers’ guidance and counseling to be at a significant level (robserved > rtable [.401 > .161]), and the effect of management ability on the motivation of the teachers’ guidance and counseling to be at a significant level (robserved > rtable [.261 > .161]). From the data analysis results, it can be seen that the principal’s transformational leadership is more influential on the motivation of the teachers’ guidance and counseling work (robserved .401).
What factors influence our reconstructions of Morrison Formation sauropod diversity?

The Upper Jurassic Morrison Formation classically represents the “Golden Age” of sauropods, and the Morrison Formation is reported to have yielded 13 genera and 24 species of sauropods. This incredible diversity has produced numerous theories attempting to reconcile the co-occurrence of such large, and similar taxa. Previously, a comparably high diversity has been proposed for the Late Cretaceous Hell Creek Formation of North America – possibly comprising nearly three dozen species from over 20 genera of ankylosaura, caenagnathids, ceratopsians, dromaeosaurids, hadrosaurs, ornithomimids, pachycephalosaurs, thescelosaurs, and tyrannosaurs. However, much of the morphologic variation previously ascribed to taxonomic differences has recently been shown to be a result of stratigraphy and/or ontogeny – resulting in this rich assemblage being downsized to 13 genera and 16 species. Whereas still rich in diversity, such factors have an immediate effect towards our reconstruction of true richness.Following the example of the Hell Creek Formation, we can investigate the ontogenetic and strati-graphic origin of possible diversity inflation in other formations, and within this study, apply it to the Morrison Formation. New dating techniques are resulting in finer temporal resolution, and are changing the temporal position of well-known quarries. Differences in body size and ontogenetic stages can also affect diversity estimates. Plotting body size stratigraphically, it initially appears that larger specimens (interpreted as different species) occur higher in the section. An increase in average body size may be a legitimate trend, but there are several specimens that counter this “rule” for many genera. Likewise, dramatic allometric ontogenetic trajectories have led to the erection of at least three diplodocid genera – Amphicoelias, Seismosaurus, and Suuwassea – and it is suspected that many more Morrison Formation “species” could alternatively be explained as ontogimorphs. We have a long way to go towards revealing the true nature of Morrison Formation sauropod diversity. Although dietary partitioning undoubtedly occurred at the level of both the species (e.g., Brachiosaurus vs. Diplodocus) and between ontogenetic stages, a base of 24 levels of co-occurring divisions seems unlikely. The Morrison Formation may have exhibited a sauropod-rich assemblage unlike any other in North America, and the implications of stratigraphy, ontogeny, and variation may be minor, yet these factors alter perceived “diversity. ” True diversity will not be fully understood unless these factors are considered.
Study of variables involved in hospital-acquired urinary tract infections at a university hospital

OBJECTIVE: Analyze bacteria involved in urinary tract nosocomial infections (UTIs), their sensitivity profile, and other correlated clinical variables. METHODS: This was a retrospective study, based on the analysis of positive urine culture reports (from100,000CFU/ml) for nosocomial infection covering the years 2009, 2010 and 2011, and on medical records. Statistical analysis was performed through SPSS 19.0 software, using chi-square tests with Yates correction and Pearson's correlation coefficient. p OBJETIVO: Analisar as bacterias envolvidas nas infeccoes do trato urinario (ITUs) nosocomiais, perfil de sensibilidade, e outras variaveis clinicas correlacionadas. METODOS: Estudo retrospectivo, com base na analise dos laudos de urocultura positiva (a partir de 100 mil UFC/ml) para infeccao nosocomial abrangendo os anos 2009, 2010 e 2011, em prontuarios medicos. A analise estatistica foi realizada no SPSS 19.0, utilizando os testes do qui-quadrado com correcao de Yates e coeficiente de correlacao de Pearson. Considerou-se estatisticamente significativo p
Anharmonic Potentials Analysis through the Floquet Representation

We propose an approach based on Floquet theorem combined with the resonating averages method (RAM), to solve the time-dependent Schrodinger equation with a time-periodic Hamiltonian. This approach provides an alternative way to determine directly the evolution operator, and then we deduct the wave functions and the corresponding quasi-energies, of quantum systems. An application is operated for the driven cubic or/and quatric anharmonic as well as for the Morse potential. Comparisons of our results with those of other authors are discussed, and numerical evaluations are performed, to determine the dissociation energy of (HCl) and (CO) molecules.
CANCER MORTALITY IN NORTH CYPRUS 1995-2007

BACKGROUND: From 1995 to 2007, ageâ€‘standardized total cancer mortality rates in the North Cyprus (NC)Â fell by around 9% in both sexes. Available cancer mortality data in Europe up to 2002 allow a first check ofÂ the forecast of further declines in cancer mortality. MATERIALS AND METHODS: We considered trends inÂ ageâ€‘standardized mortality from major cancer sites in the NC during the period 1995-2007. RESULTS: InÂ women, total cancer mortality declined by 23% from 92/100 000 to 75/100 000 between the years 1995â€‘2007. Â Corresponding figures for men were 85/100 000 to 66/100 000, corresponding to falls of 23% from 1995 toÂ 2007. Lung cancer in men declined from 20/100 000 around 1995 to 16 around 2007 (âˆ’20%). In women, lungÂ cancer mortality was 2/100 000 and there were no changes between the years 1995 and 2007. Bladder cancerÂ declined by 25% for both men and women from 1995 to 2007. Breast cancer mortality declined from 18/100 000Â around 1995 to 15/100 000 (âˆ’16%) in 2007. Prostate cancer was approximately stable until 2000, but declinedÂ from 8 to 6 (âˆ’25%) in 2007. CONCLUSIONS: Despite the persisting rises in female lung cancer in the EU, theÂ recent trends in cancer mortality in the NC are encouraging and indicate that a 9% reduction in total cancerÂ mortality from 1995 to 2007 is realistic and possible.