Miracle-dz/UniFAR-FTUs huggingface dataset:
Adverse pregnancy and birth outcomes associated with Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum: a systematic review and meta-analysis

Objectives Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum (genital mycoplasmas) commonly colonise the urogenital tract in pregnant women. This systematic review aims to investigate their role in adverse pregnancy and birth outcomes, alone or in combination with bacterial vaginosis (BV). Methods We searched Embase, Medline and CINAHL databases from January 1971 to February 2021. Eligible studies tested for any of the three genital mycoplasmas during pregnancy and reported on the primary outcome, preterm birth (PTB) and/or secondary outcomes low birth weight (LBW), premature rupture of membranes (PROM), spontaneous abortion (SA) and/or perinatal or neonatal death (PND). Two reviewers independently screened titles and abstracts, read potentially eligible full texts and extracted data. Two reviewers independently assessed risks of bias using published checklists. Random effects meta-analysis was used to estimate summary ORs (with 95% CIs and prediction intervals). Multivariable and stratified analyses were synthesised descriptively. Results Of 57/1194 included studies, 39 were from high-income countries. In meta-analysis of unadjusted ORs, M. hominis was associated with PTB (OR 1.87, 95% CI 1.49 to 2.34), PROM, LBW and PND but not SA. U. urealyticum was associated with PTB (OR 1.84, 95% CI 1.34 to 2.55), PROM, LBW, SA and PND. U. parvum was associated with PTB (1.60, 95% CI 1.12 to 2.30), PROM and SA. Nine of 57 studies reported any multivariable analysis. In two studies, analyses stratified by BV status showed that M. hominis and U. parvum were more strongly associated with PTB in the presence than in the absence of BV. The most frequent source of bias was a failure to control for confounding. Conclusions The currently available literature does not allow conclusions about the role of mycoplasmas in adverse pregnancy and birth outcomes, alone or with coexisting BV. Future studies that consider genital mycoplasmas in the context of the vaginal microbiome are needed. PROSPERO registration number CRD42016050962.
The Relationship between the Sexual Double Standard and Women’s Sexual Health and Comfort

Abstract The current research explores the relationship between Sexual Double Standard (SDS) endorsement and women’s sexual health and attitudes. Women (n = 705) completed an SDS endorsement scale, and then answered a variety of questions in three main categories of outcome variables: sexual comfort, sexual reputation, and sexual health. Results suggest that women’s SDS endorsement was not related to women’s sexual comfort. Further, SDS endorsement was slightly positively related to how concerned women were about their sexual reputation. Regarding sexual health, SDS endorsement was related to a shorter timespan since women’s last OBGYN screening, and unrelated to women’s discomfort discussing birth control with their OBGYN. Results suggest there is much more to explore in targeted studies on the relationship of SDS endorsement to women’s perceptions of their sexual reputations and their interactions with OBGYNs with respect to the SDS. Previous and related research is discussed, along with implications of the current research.
Comprehensive Sexuality Education Improves Primary Students’ Explicit and Implicit Attitudes Toward Homosexuality

Abstract Comprehensive sexuality education (CSE) is a curriculum-based process that is inclusive to gender and sexual orientation. We used the attitude toward homosexuality scale and the single category implicit association test (SC-IAT) to measure differences between explicit and implicit attitudes toward homosexuality between migrant children with 6 years CSE learning experience (experimental group, N = 70) and those without (control group, N = 80). We found that the experimental group had more positive explicit and implicit attitudes toward homosexuality than the control group. In conclusion, CSE is a useful process for improving the explicit and implicit attitudes of migrant children toward homosexuality.
Senolytics in the treatment of diabetic retinopathy

Diabetic retinopathy (DR) is the most common complication of diabetes. DR is characterized by damage to retinal vasculature resulting in vision impairment and, if untreated, could eventually lead to blindness. The pathogenic mechanism of DR is complex; emerging studies suggest that premature senescence of retinal cells and subsequent secretion of inflammatory cytokines exacerbate DR disease state by stimulating paracrine senescence, pathological angiogenesis, and reparative vascular regeneration. Senolytics are a new class of drugs that can selectively clear out senescent cells from the retina, thus holding a significant promise in DR treatment and prevention. In this review, we discuss the critical role of cellular senescence in DR’s pathogenesis; A literature review was conducted in September of 2021 to explore the therapeutic potential of senolytics in the treatment of DR. Studies that were relevant to the research topic were selected through multiple keyword searches in the search engine, PubMed and thoroughly reviewed using abstracts and full-text articles. We present evidence from animal models for studying cellular senescence in DR and discuss multiple pathogenic mechanisms in cellular senescence and its involvement in DR. We also discuss the current state of pharmaceutical development at preclinical and clinical stages focusing on the senolytic drugs navitoclax, 17-DMAG, piperlongumine, UBX-1325, dasatinib quercetin, and fisetin. In particular, UBX-1325 holds a promising prospect for DR treatment based on the positive outcome of early clinical studies in individuals with diabetic macular edema (DME) and wet age-related macular degeneration.
Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer

Abstract We aimed to study the function and mechanism of endothelial cell-specific molecule 1 (ESM1) in endometrial cancer (EC). The binding relationship between SPI1 and ESM1 was predicted by bioinformatics analysis and verified by the dual-luciferase reporter assay. The expressions and effects of SPI1 and ESM1 were determined using quantitative real-time PCR, immunohistochemistry, Western blot, and functional experiments. ESM1 was highly expressed in EC and was associated with the poor prognosis of patients. ESM1 silencing suppressed the viability, proliferation, invasion, and angiogenesis of EC cells, down-regulated expressions of PCNA, N-cadherin, Vimentin, VEGFR-1, VEGFR2, and EGFR, but upregulated E-cadherin level, while ESM1 overexpression did oppositely. Moreover, SPI1 bound to ESM1. Overexpressed SPI1 promoted the expression of ESM1 and induced malignant phenotype (viability, proliferation, and invasion), which were countervailed by ESM1 silencing. Collectively, ESM1 induced by SPI1 promotes the malignant phenotype of EC.
A consistency relation for the observed galaxy bispectrum and the local non-Gaussianity from relativistic corrections

We obtain a consistency relation for the observed three-point correlator of galaxies. It includes relativistic effects and it is valid in the squeezed limit. Furthermore, the consistency relation is non-perturbative and can be used at arbitrarily small scales for the short modes. Our results are also useful to compute the non-linear relativistic corrections which induce a signal in the observations that might be misinterpreted as primordial non-Gaussianity with a local shape. We estimate the effective local non-Gaussianity parameter from the relativistic corrections. The exact value depends on the redshift and the magnification bias. At redshift of z=1.5, in the absence of magnification bias, we get fGRNL ≃ − 3.0 .
The digitalisation of service work: A comparative study of restructuring of the banking sector in the United Kingdom and Luxembourg

The article compares the process of digitalisation and outcomes from work restructuring in two banks from the United Kingdom and Luxembourg. The banking sectors in both countries have been challenged by digitalisation pressures such as online and mobile banking, pressures from ‘Fintech’ banks, and the automation of back-office operations. Yet, the adjustment paths in the two countries differed. In Luxembourg, there is an adjustment via limited lay-offs, and increased training and reskilling; however, in the United Kingdom, the main outcomes revolve around branch downsizing and offshoring of employment. These outcomes are explained by differences in institutional supports for collective voice institutions, as well as the role of the state. The findings demonstrate that the embedded employment relations’ institutions and actors have shaped distinct paths of adjustment to digitalisation; and show how the impact of technology on work is neither deterministic nor unidirectional.
Present-day and future Greenland Ice Sheet precipitation frequency from satellite :::::::::::::: CloudSat : observations and an ::::: the :::::::::::::::::: Community : Earth System Model

The dominant mass input component of the Greenland Ice Sheet (GrIS) is precipitation, whose amounts and phase are poorly constrained by observations. Here we use spaceborne radar observations from CloudSat to map the precipitation frequency and phase on the GrIS, and use those observations, in combination with a satellite simulator to enable direct comparison between observations and model, to evaluate present-day precipitation frequency in the Community Earth System Model (CESM). The observations show that substantial variability of snowfall frequency over the GrIS exists, that snowfall occurs 5 throughout the year, and snowfall frequency peaks in Spring and Fall. Rainfall is rare over the GrIS, and only occurs in regions under 2000 m elevation and to the peak summer season. Although CESM overestimates the rainfall frequency, it reproduces the spatial and seasonal variability of precipitation frequency reasonably well. Driven by a high-emission, worst-case RCP8.5 :::::::::::: Representative :::::::::::: Concentration ::::::: Pathway :::::: (RCP) ::: 8.5 scenario, CESM indicates that rainfall frequency will increase considerably across the GrIS, and will occur at higher elevations, potentially exposing a much larger GrIS area to rain and associated melt- 10 water refreezing, ﬁrn warming, and reduced storage capacity. This technique can be applied to evaluate precipitation frequency in other climate models, and can aid in planning future satellite campaigns. These observations were subsequently used to evaluate precipitation frequency output generated by CESM. The model is equipped with a satellite simulator, which allows for a consistent ’apples-to-apples’ comparison with the observations. The results showed that, while CESM overestimates precipitation frequency on the GrIS overall, the model shows a realistic seasonal cycle and spatial gradients. ::: The ::::::::: differences ::::::: between :::::: CESM :::: and :::::::: CloudSat ::: are, :: at :::: least :::::: partly, ::::::: ascribed :: by ::: the :::::: limited ::::::::: horizontal resolution ::::::: (around :: 1 :::::: degree) :: of ::::: both :::::::: products. :::: Here ::: we ::::: show :::: that ::::::::: topography :::::::::: smoothing :: in :::::: CESM ::::: leads :: to ::::::::::::: underestimated precipitation frequency ::::: along ::: the ::::: GrIS :::::: edges. ::::: While ::: the ::::::
Deficit Budget and Economic Growth in Nepal MANAGEMENT DYNAMICS

This article attempts to identify the relationship between budget deficit and economic growth in Nepal. A deficit budget is associated with the role of government in the economy. On employing the ARDL bounds test on the data set from 1990 to 2020, it is found that there is a long-run relationship between the budget deficit and economic growth. The bound test and error correction term specify a long-run relationship between the Nepalese economy’s budget deficit and economic growth. According to the empirical study, the budget deficit significantly impacts real GDP, a proxy for economic growth.
Reply on RC2

The manuscript entitled “Mass spectrometric measurements of ambient ions and estimation of gaseous sulfuric acid in the free troposphere and lowermost stratosphere during the CAFE-EU/BLUESKY campaign” by Zauner-Wieczorek and co-authors presents ion measurements in the UTLS region. To this end, an APIToF-MS was operated onboard the HALO aircraft and sampled air masses primarily over Western Europe. The negative ion mode was found to be dominated by NO3and HSO4as well as clusters thereof. Based on the measured ion concentrations the number concentration of sulfuric acid was derived. The positive ion mode was studied in less detail but protonated pyridine was identified as a major ion. Based on the data presented an increase of nitrate ions with altitude was found while hydrogen sulfate ions as well as sulfuric acid showed a more evenly distributed trend. My overall assessment of this manuscript is quite positive and it clearly fits the scope of ACP. Especially the introduction is well written and gives a nice overview of previous work, however, a few things need clarification and improvement before final approval.
Structure-function analysis of megakaryoblastic leukemia 1 in megakaryocyte polyploidization

Structure-function analysis of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. target sites. Having defined the functions of the five domains of MKL1 in normal megakaryocyte maturation, future studies may seek to shed on how these domains function in AMKL, how overexpression of MKL1 in leukemic cells the fusion may cell proliferation and megakaryocyte maturation including polyploidization.
Review Response for: Characterization of Titan Dome, East Antarctica, and potential as an ice core target

work work. This new observations that support numerous hypothesis. The most important of which is that ice age at this location is too young to study the middle Pliestocene transition. Also relevant and of interest, the observations support the hypothesis proposed in (Beem et al., 2017) and those ramiﬁcations are addressed in the discussion section. We think it well within the typical practice to build upon past work, even our own, and discuss the new observations within the context of past work.
Constructing a wider view on memory: Beyond the dichotomy of field and observer perspectives

: Memory perspectives on past events allegedly take one of two shapes. In field memories, we recall episodes from a first-person point of view, while in observer memories we look onto a past scene from a third-person perspective. But this mere visuospatial dichotomy faces several practical and conceptual challenges. First, this binary distinction is not exhaustive. Second, this characterization insufficiently accounts for the phenomenology of observer memories. Third, the focus on the visual aspect of memory perspective neglects emotional, agential and self-related social aspects. Fourth, the focus on the time of recall neglects the fact that visual, emotional, agential and social aspects of perspective can also be dissociated in the original experience. In this chapter, we move away from the standard visual dichotomy. Instead, we propose that memory perspective is better understood along four lines: visual, agential, emotional, and social. Drawing on empirical research, we argue that these dimensions predict a disposition to recall a past event based on the present situation of the memorizer. This account supports seeing episodic memory as a natural kind, supported by scenario construction mechanisms and minimal memory traces. By remapping the classic distinction between field and observer perspective along four dimensions, our proposal provides explanatory advantages and secures practical gains by enabling testable hypotheses.
Detecting Weak Identi(cid:12)cation by Bootstrap ∗

This paper proposes to use bootstrap resampling as a diagnostic tool to detect the existence of weak identiﬁcation in IV and GMM. When identiﬁcation is strong, the bootstrap distribution of the IV/GMM estimator converges to a normal distribution. Consequently, the substantial diﬀerence between the bootstrap distribution and the normal distribution provides statistical evidence against the null of strong identiﬁcation. I propose to extract the evidence by comparing the conventional t /Wald-based conﬁdence interval with the bootstrap percentile conﬁdence interval, and provide a quantitative threshold to distinguish between strong and weak identiﬁcation. Unlike other existing tests, the proposed method has the unique feature of providing a graphic view of the identiﬁcation strength, which is illustrated by an empirical example.
Sex Analysis of Lipid Profile in Diabetes Patients with and without Over Weight in Tikrit City/Iraq

Background: The overweight is one of the main reasons for the development of diabetes, so the lipid profile is different between the diabetes and the healthy people. In addition, there is a variation between the lipids profile according to sex difference in the diabetes patients. The main goal of the current study was to assessment the relationship between lipid profiles-based sex difference of diabetes patients (with and without overweight) and control group. Methodology: In this study, the glucose level and lipid profiles were determined for one hundred and forty volunteers, thirty-nine of them were healthy as a control group (25 females and 16 males), and one hundred and two had diabetes, 50 diabetes with overweight (25 females and 25 males) and 52 diabetes without overweight (27 females and 25 males). Results: Concerning the results of glucose level, the results of the current study showed significant differences between males and females in HbA1c test of control group (P=0.024) and in PPG test of Diabetes without overweight group (P=0.033). On other hands, our results found variation between men and women in other groups but not reach to significant differences. While the results of lipids profile showed significant differences between males and females in HDL_C test of diabetes without overweight group (P=0.0246) and in LDL_C test of control group (P=0.02). At the same time, our results recorded variation between men and women in other groups but not reach to significant differences. Conclusions: The research presents important results on the differences between sex and its content of lipid profiles in diabetic patients, although some differences did not reach at significant level, but they showed clear sex differences.
Family Violence, Depressive Symptoms, School Bonding, and Bullying Perpetration: An Intergenerational Transmission of Violence Perspective

ABSTRACT Ample evidence suggests that exposure to family violence associates with bullying perpetration (BP). However, much is unknown about the underlying mechanism such as depressive symptoms and the moderating role of school bonding in these relationships. Thus, this study first examined the link between exposure to family violence and BP. Second, the mediating role of depressive symptoms on the relationship between exposure to family violence and BP. Third, this study explored whether school bonding moderated the relationships among exposure to family violence, depressive symptoms, and BP while controlling for substance use (N = 2,273). Results suggest that exposure to family violence is positively associated with BP. Mediation results suggest that depressive symptoms explained relationship between exposure to family violence and BP. Moderation results suggest school bonding did not buffer the association between exposure to family violence and depressive symptoms. However, school bonding weakened the relationship between exposure to family violence and BP. Practical and theoretical implications are discussed.
Biomimetic Force and Impedance Adaptation Based on Broad Learning System in Stable and Unstable Tasks: Creating an Incremental and Explainable Neural Network With Functional Linkage

This article presents a novel biomimetic force and impedance adaption framework based on the broad learning system (BLS) for robot control in stable and unstable environments. Different from iterative learning control, the adaptation process is realized by a neural network (NN)-based framework, similar to a BLS, to realize a varying learning rate for feedforward force and impedance factors. The connections of NN layers and settings of the feature nodes are related to the human motor control and learning principle that is described as a relationship among feedforward force, impedance, reflex and position errors, and so on to make the NN explainable. Some comparative simulations are created and tested in five force fields to verify advantages of the proposed framework in terms of force and trajectory tracking efficiency and accuracy, robust responses to different force situations, and continuity of force application in a mixed stable and unstable environment. Finally, an experiment is conducted to verify effectiveness of the proposed method.
Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity

The reductionist concept, based on the ligand–receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in many conditions. This review, for the first time, provides a rationale for the pleiotropic therapeutic efficacy of adaptogens based on evidence from recent gene expression studies in target cells and where the network pharmacology and systems biology approaches were applied. The specific molecular targets and adaptive stress response signaling mechanisms involved in nonspecific modes of action of adaptogens are identified.
Opportunistic Symbiotic Backscatter Communication Systems

This letter proposes an opportunistic commensal mechanism (OppCom) and an opportunistic parasitic mechanism (OppPar) for a pair of backscatter devices (BDs) to strengthen the concurrent transmission of the primary and the backscatter systems. It is shown that the asymptotic outage probability of the OppCom and OppPar mechanisms is not affected by the channel statistics between the two BDs. Also, for the OppPar mechanism, the backscatter efficiency ratio between the two BDs, instead of their individual values, dominates the system outage performance and a larger difference of the backscatter efficiencies leads to a better transmission robustness.
Exposure to Infrasound — Perception and Changes in Wakefulness

The present paper is a description of some laboratory experiments carried out in order to investigate the perception and changes in wakefulness occurring during exposure to infrasound. Perception of infrasound is based on hearing and vibrations in different parts of the body. Threshold of audibility was found to be approximately 110 dB(lin) at 4 Hz and 90 dB(lin) at 20 Hz. Sensations through vibrations were found to occur at about 20 dB above the hearing threshold levels. As far as vibrotactile sensation is concerned no difference was found to exist between deaf and hearing subjects. Hearing sensations could not be registered for neurosensory deafness. 10 deaf and 10 hearing subjects were exposed for 20 minutes at 6 Hz, 115 dB(lin). Reduced wakefulness was noticed among the hearing subjects but not among the deaf subjects. According to these results, changes in wakefulness of infrasound is based on cochlear stimulation. It is suggested that a reduction in wakefulness that is attributable to infrasound occurs at pressure levels close to the auditory threshold.