Miracle-dz/UniFAR-FTUs huggingface dataset:
Health-Related Problems and Drivers of Health-Related Quality of Life Among Community-Dwelling Older Adults

Purpose: The aims of this study were to explore prevalence of health-related problems and identify factors associated with health-related quality of life (HRQOL) among community-dwelling older adults (CDOAs) in rural Thailand. Methods: A total of 384 CDOAs with mean age of 71 years (SD = 7.6) were recruited. The Thai Ministry of Public Health’s comprehensive geriatric assessment (CGA) was used to measure the CDOAs’ health conditions in the primary care unit of community hospitals. HRQOL of the participants was assessed by using the EQ-5D questionnaire. Results: The results showed that the most common health-related problems were risk of glaucoma (89.6%) and hypertension (64.6%). The HRQOL were predicted by the incidence of falls (β = −0.076, P < .001), Timed Up and Go Test (β = −0.087, P < .001), and age (β = −0.667, P = .002). Discussion: This study highlighted the need to incorporate CGA in family practice, which included risk of falls assessment by measuring TUG test, fall prevention, and to provide resources for caring older adults at home which ultimately will improve CDOAs’ quality of life.
Despite Low Obesity Rates, Body Mass Index Under-Estimated Obesity among Russian Police Officers When Compared to Body Fat Percentage

In some countries, obesity rates among police officers are higher than the general public, despite physically demanding jobs. Obesity rates based on body mass index (BMI) may lack accuracy as BMI does not directly address body composition. Since data are lacking for obesity rates among Russian police officers, this study documented and compared officer obesity rates to the adult Russian population and compared the accuracy of body mass index (BMI) for obesity classification to two direct measures of body composition. Moscow region police officers (N = 182, 84% men) underwent height, weight, waist circumference (WC), and body fat percentage (BF%) bioelectrical impedance measurements during annual medical examinations. BMI-defined obesity rates were 4.6% for men and 17.2% for women, which were >3 and >1.8 times lower than Russian adults, respectively. WC-defined obesity rates were similar to BMI (3.3% for men and 10.3% for women), but BF%-defined obesity rates were much higher (22.2% for men and 55.2% for women). Although obesity rates were lower than those found among police officers in other countries, BMI alone was not a particularly accurate method for classifying weight status among Russian police officers.
Pediatric Pulmonology

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK The Asthma UK Centre for Allergic Mechanisms in Asthma, King's College London, London, UK Neonatal Intensive Care Unit, King's College Hospital NHS Foundation Trust, London, UK NIHR Biomedical Research Centre at Guy's and St Thomas’ NHS Foundation Trust and King's College London, London, UK
Partial Inhibition of Glycolysis Reduces Atherogenesis Independent of Intraplaque Neovascularization in Mice

Supplemental Digital Content is available in the text. Objective: Intraplaque neovascularization is an important feature of unstable human atherosclerotic plaques. However, its impact on plaque formation and stability is poorly studied. Because proliferating endothelial cells generate up to 85% of their ATP from glycolysis, we investigated whether pharmacological inhibition of glycolytic flux by the small-molecule 3PO (3-[3-pyridinyl]-1-[4-pyridinyl]-2-propen-1-one) could have beneficial effects on plaque formation and composition. Approach and Results: ApoE−/− (apolipoprotein E deficient) mice treated with 3PO (50 µg/g, ip; 4×/wk, 4 weeks) showed a metabolic switch toward ketone body formation. Treatment of ApoE−/−Fbn1C1039G+/− mice with 3PO (50 µg/g, ip) either after 4 (preventive, twice/wk, 10 weeks) or 16 weeks of Western diet (curative, 4×/wk, 4 weeks) inhibited intraplaque neovascularization by 50% and 38%, respectively. Plaque formation was significantly reduced in all 3PO-treated animals. This effect was independent of intraplaque neovascularization. In vitro experiments showed that 3PO favors an anti-inflammatory M2 macrophage subtype and suppresses an M1 proinflammatory phenotype. Moreover, 3PO induced autophagy, which in turn impaired NF-κB (nuclear factor-kappa B) signaling and inhibited TNF-α (tumor necrosis factor-alpha)–mediated VCAM-1 (vascular cell adhesion molecule-1) and ICAM-1 (intercellular adhesion molecule-1) upregulation. Consistently, a preventive 3PO regimen reduced endothelial VCAM-1 expression in vivo. Furthermore, 3PO improved cardiac function in ApoE−/−Fbn1C1039G+/− mice after 10 weeks of treatment. Conclusions: Partial inhibition of glycolysis restrained intraplaque angiogenesis without affecting plaque composition. However, less plaques were formed, which was accompanied by downregulation of endothelial adhesion molecules—an event that depends on autophagy induction. Inhibition of coronary plaque formation by 3PO resulted in an overall improved cardiac function.
Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex

Neocortex expansion is largely based on the proliferative capacity of basal progenitors (BPs), which is increased by extracellular matrix (ECM) components via integrin signaling. Here we show that the transcription factor Sox9 drives expression of ECM components and that laminin 211 increases BP proliferation in embryonic mouse neocortex. We show that Sox9 is expressed in human and ferret BPs and is required for BP proliferation in embryonic ferret neocortex. Conditional Sox9 expression in the mouse BP lineage, where it normally is not expressed, increases BP proliferation, reduces Tbr2 levels and induces Olig2 expression, indicative of premature gliogenesis. Conditional Sox9 expression also results in cell-non-autonomous stimulation of BP proliferation followed by increased upper-layer neuron production. Our findings demonstrate that Sox9 exerts concerted effects on transcription, BP proliferation, neuron production, and neurogenic vs. gliogenic BP cell fate, suggesting that Sox9 may have contributed to promote neocortical expansion.
Downscaling screening cultures in a multifunctional bioreactor array‐on‐a‐chip for speeding up optimization of yeast‐based lactic acid bioproduction

A key challenge for bioprocess engineering is the identification of the optimum process conditions for the production of biochemical and biopharmaceutical compounds using prokaryotic as well as eukaryotic cell factories. Shake flasks and bench‐scale bioreactor systems are still the golden standard in the early stage of bioprocess development, though they are known to be expensive, time‐consuming, and labor‐intensive as well as lacking the throughput for efficient production optimizations. To bridge the technological gap between bioprocess optimization and upscaling, we have developed a microfluidic bioreactor array to reduce time and costs, and to increase throughput compared with traditional lab‐scale culture strategies. We present a multifunctional microfluidic device containing 12 individual bioreactors (Vt = 15 µl) in a 26 mm × 76 mm area with in‐line biosensing of dissolved oxygen and biomass concentration. Following initial device characterization, the bioreactor lab‐on‐a‐chip was used in a proof‐of‐principle study to identify the most productive cell line for lactic acid production out of two engineered yeast strains, evaluating whether it could reduce the time needed for collecting meaningful data compared with shake flasks cultures. Results of the study showed significant difference in the strains' productivity within 3 hr of operation exhibiting a 4‐ to 6‐fold higher lactic acid production, thus pointing at the potential of microfluidic technology as effective screening tool for fast and parallelizable industrial bioprocess development.
Confocal Analysis of the Distribution and Persistence of Sindbis Virus (TaV-GFP) Infection in Midguts of Aedes aegypti Mosquitoes

Abstract Biological transmission of arthropod-borne viruses (arboviruses) to vertebrate hosts by hematophagous insects poses a global threat because such arboviruses can result in a range of serious public health infectious diseases. Sindbis virus (SINV), the prototype Alphavirus, was used to track infections in the posterior midgut (PMG) of Aedes aegypti adult mosquitoes. Females were fed viremic blood containing a virus reporter, SINV [Thosea asigna virus-green fluorescent protein (TaV-GFP)], that leaves a fluorescent signal in infected cells. We assessed whole-mount PMGs to identify primary foci, secondary target tissues, distribution, and virus persistence. Following a viremic blood meal, PMGs were dissected and analyzed at various days of post blood-feeding. We report that virus foci indicated by GFP in midgut epithelial cells resulted in a 9.8% PMG infection and a 10.8% dissemination from these infected guts. The number of virus foci ranged from 1 to 3 per individual PMG and was more prevalent in the PMG-middle > PMG-frontal > PMG-caudal regions. SINV TaV-GFP was first observed in the PMG (primary target tissue) at 3 days post blood-feeding, was sequestered in circumscribed foci, replicated in PMG peristaltic muscles (secondary target tissue) following dissemination, and GFP was observed to persist in PMGs for 30 days postinfection.
Comparison between different surface treatment methods on shear bond strength of zirconia (in vitro study)

Background To compare the effect of Er:YAG Laser and Air particle abrasion (APA) surface treatments on shear bond strength of Y-TZP to composite resin cuboids in the presence and absence of primer application and salivary contamination. Material and Methods Seventy-two cuboidal shaped specimens 7x7x3 were prepared from Y-TZP using CADCAM, cleaned and sintered. Specimens were divided into 2 main groups (n=36) according to surface treatment method; Air particle abrasion (A) and laser (L). Each group was subdivided into 2 subgroups (N = 18) according to surface modification using primer; each subgroup was further divided into 2 subdivisions (N=9) according to the presence of salivary contamination; APC (Air particle abrasion, primer, contamination), AP (Air particle abrasion, primer), AC (Air particle abrasion, contamination), A (Air particle abrasion), LPC (Laser, primer, contamination), LP (Laser, primer), LC (Laser, contamination), L (Laser). Composite cuboids having dimensions of 6x6x3 were also fabricated using custom made plexi plates. Composite cuboids were cemented centrally to zirconia cuboids and light cured under 5 kg weight for 6 mins. Shear bond strength of specimens was measured utilizing universal testing machine at a crosshead speed of 0.5 mm/min. Failure loads were recorded in Newton. SBS was calculated according to equation: SBS (MPa) = load (N)/area(mm2). Results Viewing shear bond strength between studied groups, group APNC (484.02±85.02) showed higher mean value compared to ANPNC (122.09±55.80), also LNPNC (120.87±65.10) showed higher mean value in comparison to LPNC (170.78±53.22). APNC (484.02±85.02) and APC (592.22±189.65) showed higher mean values than LPNC (170.78±53.22) and LPC (3227.66±108.28) in sequence. Conclusions APA showed higher SBS values than Er:YAG surface treatment. Primer showed better results than no primer coating. Artificial saliva contamination did not affect the SBS of zirconia compared with no contamination results. Key words:Shear bond strength, zirconia, air particle abrasion, Er:YAG laser, primer, contamination.
Pharmacokinetics, Tissue Distribution, and Druggability Prediction of the Natural Anticancer Active Compound Cytisine N-Isoflavones Combined with Computer Simulation.

Cytisine N-methylene-(5,7-dihydroxy-4'-methoxy)-isoflavone (CNF2) is a new compound isolated from the Chinese herbal medicine Sophora alopecuroides. Preliminary pharmacodynamic studies demonstrated its activity in inhibiting breast cancer cell metastasis. This study examined the pharmacokinetics, absolute bioavailability, and tissue distribution of CNF2 in rats, and combined computer-aided technology to predict the druggability of CNF2. The binding site of CNF2 and the breast cancer target HER2 were examined with molecular docking technology. Next, ACD/Percepta software was used to predict the druggability of CNF2 based on the quantitative structure-activity relationship (QSAR). Finally, a simple and effective high-performance liquid chromatography (HPLC) method was used to determine plasma pharmacokinetics and tissue distribution of CNF2 in rats. Prediction and experimental results show that compared with the positive control HER2 inhibitor SYR127063, CNF2 has a stronger binding affinity with HER2, suggesting that its efficacy is stronger; and the structure of CNF2 complies with the Lipinski's Rule of Five and has good drug-likeness. The residence time of CNF2 in rats is less than 4 hours, and the metabolic rate is relatively fast; But the absolute bioavailability of CNF2 in rats was 6.6%, mainly distributed in the stomach, intestine, and lung tissues, where the CNF2 contents were 401.20 μg/g, 144.01 μg/g, and 245.82 μg/g, respectively. This study constructed rapid screening and preliminary evaluation of active compounds, which provided important references for the development and further research of such compounds.
Rare Disaster Probability and Options-Pricing

We derive an option-pricing formula from recursive preferences and estimate rare disaster probability. The new options-pricing formula applies to far-out-of-the money put options on the stock market when disaster risk dominates, the size distribution of disasters follows a power law, and the economy has a representative agent with a constant-relative-risk-aversion utility function. The formula conforms with options data on the S&P 500 index from 1983-2018 and for analogous indices for other countries. The disaster probability, inferred from monthly fixed effects, is highly correlated across countries, peaks during the 2008-2009 financial crisis, and forecasts rates of economic growth. *We appreciate helpful comments and assistance with data from Josh Coval, Ben Friedman, Xavier Gabaix, Yvan Lengwiler, Matteo Maggiori, Greg Mankiw, Robert Merton, Richard Roll, Steve Ross, Emil Siriwardane, Jessica Wachter, and Glen Weyl, and seminar participants at Harvard University, MIT, and the Federal Reserve Board. We received excellent research assistance from Vickie Chang and Tina Liu. The views in this paper are solely the responsibility of the authors and should not be interpreted as reflecting the views of the Board of Governors of the Federal Reserve System or any other person associated with the Federal Reserve System. ** Corresponding author. Email addresses: rbarro@harvard.edu (R. Barro), gordon.y. liao@frb.gov (G. Liao).
Whole grain intake compared with cereal fibre intake in association to CVD risk factors: a cross-sectional analysis of the National Diet and Nutrition Survey (UK)

Abstract Objective: To investigate how intakes of whole grains and cereal fibre were associated to risk factors for CVD in UK adults. Design: Cross-sectional analyses examined associations between whole grain and cereal fibre intakes and adiposity measurements, serum lipid concentrations, C-reactive protein, systolic blood pressure, fasting glucose, HbA1c, homocysteine and a combined CVD relative risk score. Setting: The National Diet and Nutrition Survey (NDNS) Rolling Programme 2008–2014. Participants: A nationally representative sample of 2689 adults. Results: Participants in the highest quartile (Q4) of whole grain intake had lower waist–hip ratio (Q1 0·872; Q4 0·857; P = 0·04), HbA1c (Q1 5·66 %; Q4 5·47 %; P = 0·01) and homocysteine (Q1 9·95 µmol/l; Q4 8·76 µmol/l; P = 0·01) compared with participants in the lowest quartile (Q1), after adjusting for dietary and lifestyle factors, including cereal fibre intake. Whole grain intake was inversely associated with C-reactive protein using multivariate analysis (P = 0·02), but this was not significant after final adjustment for cereal fibre. Cereal fibre intake was also inversely associated with waist–hip ratio (P = 0·03) and homocysteine (P = 0·002) in multivariate analysis. Conclusions: Similar inverse associations between whole grain and cereal fibre intakes to CVD risk factors suggest the relevance of cereal fibre in the protective effects of whole grains. However, whole grain associations often remained significant after adjusting for cereal fibre intake, suggesting additional constituents may be relevant. Intervention studies are needed to compare cereal fibre intake from non-whole grain sources to whole grain intake.
Intel® Optane™ technology drastically reduces latency to data at the memory, device, and computing system level.

Intel Non-Volatile Memory Solutions Group From the very beginning, computing systems have exploited the tendency of algorithms to access some data more than other data (temporal locality), and to access data stored close together (spatial locality), to increase performance and reduce cost. Data accessed more often is held in faster, smaller memories, while bulk data accessed less frequently is held in storage, costing much less per bit. This interplay between the memories within a computing system—and software running on that system—is commonly called the memory and storage hierarchy.
DEVELOPMENT OF STANDARD BOND CAPACITY TEST FOR FRP BONDED TO CONCRETE

Efforts are underway to develop standardised tests to assess the bond capacity of FRP bonded to a concrete substrate. While several bond test configurations have been proposed and some standard tests have been promulgated, many use difficult-to-handle specimens or require relatively complex test apparatuses. This paper focuses on a simple beam-bending bond test based on concrete modulus of rupture (MOR) tests, which are simple to conduct and familiar to most in the anticipated community of users. This study addresses the following parameters that must be properly accounted for in the development of such a standard test: a) specimen size; b) ratio of FRP width-to-beam width; and c) ratio FRP-to-concrete modulus. Furthermore, the study contrasts simplified and rigorous methods of calculating internal specimen forces with measured in situ stresses in order to validate assumptions necessary in developing a standard test method.
514-530 Somboon P.pmd

Pyrethroid resistance is a problem for controlling the dengue vector Aedes aegypti worldwide. One strategy to cope with resistance is to use another insecticide with a different mode of action. Pyriproxyfen (PPF), an insect growth regulator, is normally used at very low concentrations for controlling the immature stages of mosquitoes. At high concentrations, it has a reproductive effect on exposed female mosquitoes. In this study, we demonstrated by using CDC bottle and cone bioassays that tarsal contact with 333 mg AI PPF/m2 for 1 min was sufficient to cause over 95% emergence inhibition (EI) in the progeny of exposed Ae. aegypti females. Exposure for 5 min completely inhibited fecundity. As Ae. aegypti adult mosquitoes are generally drawn towards darker areas, we evaluated the efficacy of a resting box (35x35x55 cm) treated with PPF aimed at disrupting reproductivity of free-flying mosquitoes in the laboratory. We found that the resting box led to 94% EI of exposed females, either before or after blood feeding. The resting box was also attractive for male mosquitoes. Exposed males could transfer sufficient PPF to virgin females via copulation to cause about 90% EI. Additionally, PPF-exposed gravid females from the treated resting box were able to disseminate sufficient PPF to small larvaecontaining cups to reduce adult emergence by 50%. Based on 10 min exposure, the residual effect of PPF-treated resting boxes (over 80% EI) was observed over a 4 month-period. PPF-treated resting boxes may potentially be useful in dengue vector control programs, however further evaluation under natural field conditions are needed.
Promoting The Vision And Research Mandate Of Institutions Through Mobile Technology In The 21st Century: Case Study “NILEST Mobile-App”

: Background: Technological advancement has changed the way information and awareness creation is handled in today‟s world. Developing an alternative system and a more convenient way becomes imperative for every organization. The aim of this project was to design a mobile app which could enhance the promotion of the vision and research mandate of the Institute. Method: The following applications were utilized in the design: Dreamweaver studio 8, HTML 5, Corel-Draw 15, Android cheat sheet for graphic and iOS converter. A sample of the developed mobile app was tested on both android and iOS mobile phones. Result: The result showed that the app is android compatible and user friendly. It has the ability to update her users with current information from the institute as well as local and international news. It gives easy navigation to the institute‟s social media pages online. It also show case various aspect of the institute ranging from academic policies, rules and regulations governing students activities and finally the mandate, vision and mission of the institute. Conclusion: This study demonstrated how a mobile application technology could help to propel the vision of an institute via mobile app in order to achieve her strategic set mandate and organizational goals.
Gaps in the Evidence on Employment and Training for Low-Income Adults

The Employment Strategies for Low-Income Adults Evidence Review (ESER) is a systematic review of the literature on the impacts of employment and training programs and policies for low-income people. Sponsored by the Office of Planning, Research and Evaluation (OPRE) in the Administration for Children and Families, ESER provides practitioners, policymakers, researchers, and the public with a transparent, systematic assessment of the quality of research evidence supporting approaches to improve the employment-related outcomes of low-income adults.
Dental Implant Surface Enhancement and Osseointegration

S.Anil1,4, P.S. Anand2, H. Alghamdi3,4 and J.A. Jansen3,4 1Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 2People’s College of Dental Sciences & Research Centre, Bhanpur, Bhopal, Madhya Pradesh, 3Radboud University Nijmegen Medical Center, HB Nijmegen, 4Dental Implant and Osseointegration Research Chair, King Saud University, Riyadh 1,4Saudi Arabia 2India 3The Netherlands