Miracle-dz/UniFAR-FTUs huggingface dataset:
2.4 GHz Electromagnetic Field Influences the Response of the Circadian Oscillator in the Colorectal Cancer Cell Line DLD1 to miR-34a-Mediated Regulation

Radiofrequency electromagnetic fields (RF-EMF) exert pleiotropic effects on biological processes including circadian rhythms. miR-34a is a small non-coding RNA whose expression is modulated by RF-EMF and has the capacity to regulate clock gene expression. However, interference between RF-EMF and miR-34a-mediated regulation of the circadian oscillator has not yet been elucidated. Therefore, the present study was designed to reveal if 24 h exposure to 2.4 GHz RF-EMF influences miR-34a-induced changes in clock gene expression, migration and proliferation in colorectal cancer cell line DLD1. The effect of up- or downregulation of miR-34a on DLD1 cells was evaluated using real-time PCR, the scratch assay test and the MTS test. Administration of miR-34a decreased the expression of per2, bmal1, sirtuin1 and survivin and inhibited proliferation and migration of DLD1 cells. When miR-34a-transfected DLD1 cells were exposed to 2.4 GHz RF-EMF, an increase in cry1 mRNA expression was observed. The inhibitory effect of miR-34a on per2 and survivin was weakened and abolished, respectively. The effect of miR-34a on proliferation and migration was eliminated by RF-EMF exposure. In conclusion, RF-EMF strongly influenced regulation mediated by the tumour suppressor miR-34a on the peripheral circadian oscillator in DLD1 cells.
Measurement of the forbidden tensor polarizability of Cs using an all-optical Ramsey resonance technique

We have measured the strongly suppressed electric tensor polarizability of the Cs ground state using an optical pump-probe technique in a thermal atomic beam. The result ${\ensuremath{\alpha}}_{2}(F=4)/h=\ensuremath{-}{3.34(2)}_{\mathrm{stat}}{(25)}_{\mathrm{syst}}$ ${10}^{\ensuremath{-}8}\mathrm{Hz}/(\mathrm{V}/\mathrm{c}\mathrm{m}{)}^{2}$ agrees with a previous measurement and confirms the long-standing discrepancy with a theoretical value. The anticipated future reduction of the total uncertainty to the 1% level makes this quantity a valuable test for atomic structure calculations involving short-range inner-atomic interactions.
An Analysis on The Principles of Arabic Textbooks for Madrasah Aliyah in Indonesia: Based on The Ministry of Education and Rusydi Ahmad Thu’aimah

The purpose of this study is to describe the contents of the tenth-grade Arabic textbook by Hasan Saefullah based on the 2008 Ministry of National Education standards and Ahmad Thu'aimah. The research method used is a literature study using qualitative method with descriptive content analysis techniques. The results of this study indicate that this book generally has complied with the principles of compiling the 2008 Ministry of National Education standard teaching materials. It is aligned with the principles of consistency, relevancy, and adequacy, which have been contained in competency standards and basic competencies in learning objectives. However, on the gradation principle, there is a discrepancy in the material contained in the teaching material preparation, such as the receptive and expressive language mastery section. The author places the mastery of reading skills after listening skills and grammatical mastery before speaking skills. It violates the order of language learning in general because the sequence of language learning starts from maharah istima', then maharah kalam, maharah qiroah, and finally maharah kitaba. Meanwhile, Thu'aimah standards, which includes the principles of validity, meaningfulness, and feasibility, have also been applied in the preparation of this textbook. The researchers expect that the authors of Arabic teaching materials pay more attention to several international and national standardization principles in writing Arabic teaching materials.
IAES International Journal of Artificial Intelligence (IJ-AI)

Received Jan 31, 2022 Revised Jul 22, 2022 Accepted Aug 20, 2022 In the digital world, the Internet and online media especially video media are convenient and easy to access. It leads to problems of inappropriate content media consumption among children and youths. However, measures or methods to control the inappropriate content for children and young people are still a challenge for management. In this research, an automated model was developed and presented to classify the content on online video media using a deep learning technique namely convolution neural networks (CNN). For data collection and preparation, the researchers collected video clips from movies and television (TV) series from websites that distribute the clips online. It consists of different types of content: i) sexually inappropriate content; ii) violently inappropriate content; and iii) general content. The collected video clip data was then extracted into frames and then used for developing the automatically-content-classifying model with algorithm CNN, analyzing and comparing the result of CNN model performance. For enhancing the model performance, a transfer learning approach and different regularization techniques were adopted in order to find the most suitable method to create high-performance modeling to classify content in video clips, movies and TV series published online.
Chemical Composition and Antioxidant Activity of the Essential Oils of Citral-Rich Chemotype Cinnamomum camphora and Cinnamomum bodinieri

Citral chemotypes Cinnamomum camphora (C. camphora) and Cinnamomum bodinieri (C. bodinieri) are promising industrial plants that contain abundant citral. For a more in-depth study, their significant biological effect, the chemical composition and antioxidant capacity of essential oils of citral-rich chemotype C. camphora and C. bodinieri (EOCC) were determined in the present study. The EOCC yield, obtained by hydro-distillation and analyzed by gas chromatography–mass spectrometry (GC-MS), ranged from 1.45–2.64%. Forty components more than 0.1% were identified and represented, mainly by a high content of neral (28.6–39.2%), geranial (31.8–54.1%), Z-isocitral (1.8–3.2%), E-isocitral (3.2–4.7%), geraniol (1.3–2.6%) and caryophyllene (0.6–2.4%). The antioxidant properties of EOCC were estimated by DPPH, ABTS and FRAP methods. As our results indicated, the antioxidant activity was significantly correlated to oxygenated monoterpenes. The variety of C. bodinieri (N7) presented the best antioxidant profile, given its highest inhibition of DPPH radical (IC50 = 6.887 ± 0.151 mg/mL) and ABTS radical scavenging activity (IC50 = 19.08 ± 0.02 mg/mL). To the best of our knowledge, more than 88% citral of C. bodinieri was investigated and the antioxidant properties described for the first time. Considering high essential oil yield, rich citral content and high antioxidant activity, the N7 variety will be a good candidate for pharmaceutical and cosmetic development of an improved variety.
Has the soybean oil supplementation effect on milk production, feed efficiency, and grazing behavior of Girolando cows under moderate heat stress in western Amazonia?

The effect of soybean oil supplementation in the diet of early lactating Girolando cows under moderate heat stress were studied in a grazing trial. Dry matter intake (DMI), milk yield, feed efficiency, and grazing behavior (during daytime and nighttime) were evaluated in two groups of eight crossbred Girolando (Holstein × Gyr) cows grazing palisade grass (Urochloa brizantha syn. Brachiaria brizantha) with initial means of 53±33 days in lactation and 22.6±3 kg of milk day-1. They were arranged in a 2×2 crossover trial with two supplements (with or without soybean oil), two genetic groups and two periods. During the experimental period, the mean of temperature and humidity index (THI) was 75.11, suggesting moderate heat stress. Total DMI was based on fecal production estimated by LIPE® and the diet in vitro DM digestibility (IVDMD). Grazing behavior was assessed for 48 hours by acoustic data collected with MP3 recorders. Soybean oil supplementation had no significant effects on all variables evaluated in this study. Averages of individual milk yield and total DMI were 19.26 kg day-1 and 15.32 kg DM day-1, respectively. Under moderate heat stress, oil supplementation did not change grazing behavior, dry matter intake, or milk yield in early lactating Girolando cows.
Outcomes of lower trapezius transfer with hamstring tendons for irreparable rotator cuff tears

Background The aim of this study was to evaluate the results of the transfer of the lower trapezius with a graft from hamstring tendons in the treatment of irreparable rotator cuff tears . Level IV; Case Series; Treatment Study. Methods Ten patients diagnosed with irreparable tears of the supraspinatus and infraspinatus tendons, were evaluated retrospectively -preoperatively, 6 and 12 months postoperatively. They underwent transfer of the prolonged lower trapezius with an autologous graft of the knee flexor tendons. Results The Shoulder Subjective Value increased from 47 (preoperative) to 71 (1 year after surgery), American Shoulder and Elbow Surgeons Score increased from 26.63 to 75.24. Pain improved from 7.9 to 2.5 on the Visual Analogue Scale. The mean lateral rotation improved from 31° to 51°, flexion from 84° to 122°, and abduction from 76° to 101°. These results have not changed significantly between 6 and 12 months. Discussion The transfer of the lower trapezius with autologous grafts from the hamstring tendons showed good results in patients under 65 years of age with irreparable rotator cuff tears . Longer follow-up and a greater number of cases are necessary to confirm the efficacy of the transfer.
A Working Paper WP / 18 / 024 The Mobile Phone as an Argument for Good Governance in Sub-Saharan Africa

PurposeThis study presents theoretical and empirical arguments for the role of mobile telephony in promoting good governance in 47 sub-Saharan African countries for the period 2000-2012. Design/methodology/approachThe empirical inquiry uses an endogeneity-robust GMM approach with forward orthogonal deviations to analyse the linkage between mobile phone usage and the variation in three broad governance categories — political, economic and institutional. FindingsThree key findings are established: First, in terms of individual governance indicators, mobile phones consistently stimulated good governance by the same magnitude, with the exception of the effect on the regulation component of economic governance. Second, when indicators are combined, the effect of mobile phones on general governance is three times higher than that on the institutional governance category. Third, countries with lower levels of governance indicators are catching-up with their counterparts with more advanced dynamics. Originality/valueThe study makes both theoretical and empirical contributions by highlighting the importance of various combinations of governance indicators and their responsiveness to mobile phone usage. JEL Classification: G20; O38; O40; O55; P37
DhDIT2 Encodes a Debaryomyces hansenii Cytochrome P450 Involved in Benzo(a)pyrene Degradation—A Proposal for Mycoremediation

Pollutants, such as polycyclic aromatic hydrocarbons (PAHs), e.g., benzo(a)pyrene (BaP), are common components of contaminating mixtures. Such compounds are ubiquitous, extremely toxic, and they pollute soils and aquatic niches. The need for new microorganism-based remediation strategies prompted researchers to identify the most suitable organisms to eliminate pollutants without interfering with the ecosystem. We analyzed the effect caused by BaP on the growth properties of Candida albicans, Debaryomyces hansenii, Rhodotorula mucilaginosa, and Saccharomyces cerevisiae. Their ability to metabolize BaP was also evaluated. The aim was to identify an optimal candidate to be used as the central component of a mycoremediation strategy. The results show that all four yeast species metabolized BaP by more than 70%, whereas their viability was not affected. The best results were observed for D. hansenii. When an incubation was performed in the presence of a cytochrome P450 (CYP) inhibitor, no BaP degradation was observed. Thus, the initial oxidation step is mediated by a CYP enzyme. Additionally, this study identified the D. hansenii DhDIT2 gene as essential to perform the initial degradation of BaP. Hence, we propose that D. hansenii and a S. cerevisiae expressing the DhDIT2 gene are suitable candidates to degrade BaP in contaminated environments.
Surface Properties and In Vitro Corrosion Studies of Blasted and Thermally Treated Ti6Al4V Alloy for Bioimplant Applications

The biomedical Ti6Al4V alloy was thermally treated under sandblasting and mirror finish surface preparation conditions. The surface morphology, structure, roughness, wettability, and energy were characterized. Microhardness and in vitro corrosion studies were carried out. X-ray diffraction results showed a formation of rutile TiO2 phase for thermally treated samples under different pretreated conditions. The thermally oxidized samples exhibited an increase in microhardness compared to the untreated mirror finish and sandblasted samples by 22 and 33%, respectively. The wettability study revealed enhanced hydrophilicity of blasted and thermally treated samples. The surface energy of the thermal treatment samples increased by 26 and 32.6% for mirror surface and blasted preconditions, respectively. The acquired in vitro corrosion results using potentiodynamic polarization measurement and electrochemical impedance spectroscopy confirmed the surface protective performance against corrosion in Hank’s medium. The enhanced surface characteristics and corrosion protection of treated Ti6Al4V alloy give it potential for bio-implant applications.
Disability Associated with Shoulder Pain during Life Span of Competitive Swimmers; A Cross-sectional study

Background: The occurrence of shoulder pain among competitive swimmers is bizarre, but no strategy exists to diminish shoulder injuries in swimmers. Objective: To assess the disability associated with shoulder pain across the lifespan of competitive swimmers. Methods: A cross-sectional study including 58 swimmers who were selected based on inclusion criteria for this study from different swimming centers in Lahore, Pakistan. The questionnaire consisted of a total of 28 questions, 24 questions on Penn shoulder score and 4 questions on disability of arm, shoulder and hand questionnaire score and a diagnostic side bridge test was assessed 2 times by each participant to check endurance. Manual muscle testing was performed bilaterally on the serratus anterior, middle trapezius and lower trapezius muscles. Means and standard deviations were calculated for quantitative variables while frequency and percentages were used for qualitative variables. Chi-square was estimated to find the association between disability and shoulder pain. Results: There were 21 (36.2%) males and 37 (63.2%) females participated in the study. This showed that hand dominance affects the ability of competitive swimmers. For the side bridge average time, left and right hand, the p-value was <0.001 which was statistically significant. Conclusion: This study concludes that disabilities are associated with shoulder pain across the lifespan of competitive swimmers. Pain and discomfort in the shoulder is the main risk factor among competitive swimmers that can ultimately lead to the disability of the extremity. As only a few participants were fully satisfied with the current level of their shoulder functioning.
Vaccination Confidence among Healthcare Workers: Results from Two Anamnestic Questionnaires Adopted in the COVID-19 and Influenza Campaign

Background: Following the announcement of the development of COVID-19 vaccines, hesitancy about the safety of vaccinations and their side effects have spread, despite having the approval of international drug agencies. The aim of this study was to test the hypothesis that concern about side effects may have led people to fill out the COVID-19 anamnestic vaccine questionnaire with greater attention compared to the similar instrument used for the influenza vaccination. Methods: We analyzed vaccination questionnaires of 218 healthcare workers (HCWs) who underwent both COVID-19 and influenza vaccines in 2020/2021. Outcomes included self-reported allergies, chronic pharmacological treatments, and chronic diseases. We tested the difference in prevalence, analyzed differences using the kappa statistics and concordance correlation, and explored factors associated with differences in reporting. Results: HCWs reported more allergies to substances other than drugs and a higher prevalence of chronic drug intake in the COVID-19 questionnaires than in the influenza ones. Technical staff reported more drug allergies than physicians, and other HCWs reported more outcomes than physicians in the COVID-19 questionnaire. Conclusions: We found that this population of HCWs reported higher conditions during the 2020 COVID-19 vaccination campaign compared to that of the influenza vaccine. The identification of socio-demographic characteristics of the less vaccine-confident HCWs could help in planning targeted interventions to enhance vaccine adherence.
Subgrid modelling for two-dimensional turbulence using neural networks

In this investigation, a data-driven turbulence closure framework is introduced and deployed for the subgrid modelling of Kraichnan turbulence. The novelty of the proposed method lies in the fact that snapshots from high-fidelity numerical data are used to inform artificial neural networks for predicting the turbulence source term through localized grid-resolved information. In particular, our proposed methodology successfully establishes a map between inputs given by stencils of the vorticity and the streamfunction along with information from two well-known eddy-viscosity kernels. Through this we predict the subgrid vorticity forcing in a temporally and spatially dynamic fashion. Our study is both a priori and a posteriori in nature. In the former, we present an extensive hyper-parameter optimization analysis in addition to learning quantification through probability-density-function-based validation of subgrid predictions. In the latter, we analyse the performance of our framework for flow evolution in a classical decaying two-dimensional turbulence test case in the presence of errors related to temporal and spatial discretization. Statistical assessments in the form of angle-averaged kinetic energy spectra demonstrate the promise of the proposed methodology for subgrid quantity inference. In addition, it is also observed that some measure of a posteriori error must be considered during optimal model selection for greater accuracy. The results in this article thus represent a promising development in the formalization of a framework for generation of heuristic-free turbulence closures from data.
Creative methods in STEM for secondary school students: Systematic literature review

Science, technology, engineering, and mathematics (STEM) are recognized as critical subjects that underlie innovation and national prosperity. Through inquiry-based learning, STEM subjects contribute to the development and application of these abilities. Therefore, the main purpose of this research is to explore type of creative methods in STEM for secondary school students. Articles from 2017 till 2021 screened and analyzed using systematic literature review (SLR) and PRISMA protocol. Three online search engines used are Springer, Scopus, and Science Direct. The thematic analysis method is used to analyze the data. A total of 22 articles were chosen for the systematic analysis after being screened using the eligibility requirements. Result showed that the creative teaching methods involving STEM used in the current study were a problem and project-based learning, mathematical modelling, inquiry-based learning, design-based learning, tool-based pedagogy, student-centered learning, 5E instructional model, professional development, board games and role-play, STEM 7E-learning cycle and boundary-crossing. From twenty-two articles chosen, 77% used qualitative approach in existing literature of creative thinking. Our findings indicated that the distribution of STEM education in different countries such as Australia, Germany, Indonesia, Malaysia, Spain, and the US. At the end, STEM in mathematics education gives a positive out-turn overall.
Patients Regret Their Choice of Therapy Significantly Less Frequently after Robot-Assisted Radical Prostatectomy as Opposed to Open Radical Prostatectomy: Patient-Reported Results of the Multicenter Cross-Sectional IMPROVE Study

Simple Summary This multicenter study investigated the extent of patient’s decision regret (PatR) in patients with prostate cancer comparing different surgical modalities. Robot-assisted radical prostatectomy has replaced open radical prostatectomy as the surgical standard of care in many countries worldwide. However, a broad scientific basis evaluating the difference in patient-relevant outcomes between both approaches is still lacking. In this context, PatR is increasingly moving into the scientific focus. Our study shows a critical PatR in slightly more than one third of patients about 15 months after surgery. Patients who underwent robot-assisted surgery, and also patients without postoperative urinary stress incontinence, report significantly lower PatR. Likewise, this difference was also demonstrated for patients who decided together with their treating physician on the specific surgical procedure (consensual decision making). Our study helps to further establish PatR as an important endpoint in the setting of radical prostatectomy and identifies criteria which may be addressed to reduce PatR. Abstract Patient’s regret (PatR) concerning the choice of therapy represents a crucial endpoint for treatment evaluation after radical prostatectomy (RP) for prostate cancer (PCA). This study aims to compare PatR following robot-assisted (RARP) and open surgical approach (ORP). A survey comprising perioperative-functional criteria was sent to 1000 patients in 20 German centers at a median of 15 months after RP. Surgery-related items were collected from participating centers. To calculate PatR differences between approaches, a multivariate regressive base model (MVBM) was established incorporating surgical approach and demographic, center-specific, and tumor-specific criteria not primarily affected by surgical approach. An extended model (MVEM) was further adjusted by variables potentially affected by surgical approach. PatR was based on five validated questions ranging 0–100 (cutoff >15 defined as critical PatR). The response rate was 75.0%. After exclusion of patients with laparoscopic RP or stage M1b/c, the study cohort comprised 277/365 ORP/RARP patients. ORP/RARP patients had a median PatR of 15/10 (p < 0.001) and 46.2%/28.1% had a PatR >15, respectively (p < 0.001). Based on the MVBM, RARP patients showed PatR >15 relative 46.8% less frequently (p < 0.001). Consensual decision making regarding surgical approach independently reduced PatR. With the MVEM, the independent impact of both surgical approach and of consensual decision making was confirmed. This study involving centers of different care levels showed significantly lower PatR following RARP.