Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive evaluation of plasma microbial cell-free DNA sequencing for predicting bloodstream and local infections in clinical practice: a multicenter retrospective study

Background Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA (cfDNA) shows promising application for complicated infections that cannot be resolved by conventional microbiological tests (CMTs). The criteria for cfDNA sequencing are currently in need of agreement and standardization. Methods We performed a retrospective cohort observation of 653 patients who underwent plasma cfDNA mNGS, including 431 with suspected bloodstream infections (BSI) and 222 with other suspected systemic infections. Plasma mNGS and CMTs were performed simultaneously in clinical practice. The diagnostic efficacy of plasma mNGS and CMTs in the diagnosis of blood-borne and other systemic infections was evaluated using receiver operating characteristic (ROC) curves. The sensitivity and specificity of the two methods were analyzed based on the final clinical outcome as the gold standard. Results The mNGS test showed an overall positive rate of 72.3% (472/653) for detecting microorganisms in plasma cfDNA, with a range of 2 to 6 different microorganisms detected in 171 patient specimens. Patients with positive mNGS results were more immunocompromised and had a higher incidence of severe disease (P<0·05). The sensitivity of mNGS was higher for BSI (93·5%) and other systemic infections (83·6%) compared to CMTs (37·7% and 14·3%, respectively). The mNGS detected DNA from a total of 735 microorganisms, with the number of microbial DNA reads ranging from 3 to 57,969, and a higher number of reads being associated with clinical infections (P<0·05). Of the 472 patients with positive mNGS results, clinical management was positively affected in 203 (43%) cases. Negative mNGS results led to a modified clinical management regimen in 92 patients (14.1%). The study also developed a bacterial and fungal library for plasma mNGS and obtained comparisons of turnaround times and detailed processing procedures for rare pathogens. Conclusion Our study evaluates the clinical use and analytic approaches of mNGS in predicting bloodstream and local infections in clinical practice. Our results suggest that mNGS has higher positive predictive values (PPVs) for BSI and systemic infections compared to CMTs, and can positively affect clinical management in a significant number of patients. The standardized whole-process management procedure for plasma mNGS developed in this study will ensure improved pre-screening probabilities and yield clinically valuable data.
The use of stone at Ohalo II, a 23,000 year old site in the Jordan Valley, Israel

A wide range of stones were found at the 22,000-24,000 year old lakeshore camp of Ohalo II, the Sea of Galilee, Israel. The well-preserved camp includes the floors of six brush huts, several open-air hearths, a grave, a midden, and small installations. Stones were found in all excavated loci. These include a small assemblage of basalt and limestone tools, among which bowls, grinding implements and weights are the most common. Use-wear analysis supports the identification of the grinding tools, suggesting that cereals were indeed processed with them, but not in an intensive manner. The presence of thousands of cereal grains as well as several sickle blades accord well these finds. Bowls were all shallow and only their fragments were found. Weights were likely used as fishing net sinkers. Limestone and basalt flakes indicate local knapping. Basalt and limestone fragments, shattered from heat, were abundant in all the excavated loci. Their original use is yet to be verified, but their shattering from heat was affirmed by a series of experiments. Stones were also used as wall supports. The range of types, contexts and activities reflected by stone tools and natural stones is unprecedented in other contemporaneous sites in the southern Levant.
An open-label pilot study to identify the usefulness of adjuvant homoeopathic medicines in the treatment of cerebral stroke patients

Background: Stroke, the third leading cause for neurological morbidity and mortality has a global annual incidence of 0.2–2.5/1000 population. The clinical sequelae of stroke are often devastating with hemiparesis, depression, walking difficulties and aphasia. It is essential to take measures halting the progression of stroke. Homoeopathic literature mentions many medicines for stroke. Till a pilot study was undertaken to study the usefulness of Homoeopathy as an adjuvant therapy to standard conventional care in stroke patients. Materials and Methods: An open-label pilot study was conducted at Princess Durru Shehvar Children's and General Hospital, Hyderabad, in coordination with Extension Clinical Research Unit of Central Council for Research in Homoeopathy. Fifty patients presenting with episodes of cerebral stroke of the different period were assessed by the National Institute of Health Stroke Scale (NIHSS) Score, prior homoeopathic treatment and after 6 months of treatment. Results: Of 50 patients, 10 patients had stroke more than 1 year and suffering with sequelae, 27 patients had stroke episode between 1 month and 1 year and 13 patients had a stroke episode within 4 weeks. The reduction in NIHSS score after 6 months of treatment was statistically significant in all three groups. The useful medicines found were Causticum (n = 11), Arnica montana (n = 7), Nux vomica (n = 6), Lycopodium (n = 6) and Lachesis (n = 3). Neither patient had worsening signs nor any new infarcts during the study. Conclusion: This pilot study showed encouraging results. Further randomised control trials are suggested to evaluate the efficacy of homoeopathic medicines in stroke.
Factors affecting the intention to use QRIS on MSME customers

This study investigates the factors influencing the intention to use the Quick Response Code Indonesian Standard (QRIS) among Micro, Small, and Medium Enterprises (MSMEs) customers in Indonesia. In this study, a quantitative approach was taken with the survey method using an online questionnaire that was distributed to 240 MSME customers. The collected data were analyzed using the Statistical Package for the Social Sciences (SPSS) and Structural Equation Modeling (SEM) using the Analysis of Moment Structures (AMOS) 24 to test their validity and reliability. The study results show that factors such as perceived benefits, knowledge, and perceived safety significantly affect customer confidence in using QRIS. However, perceived ease of use does not significantly affect trust. In addition, perceived usefulness, knowledge, and trust significantly influence the intention to use QRIS, while perceived ease of use and perceived safety have no significant effect. Based on these findings, increasing perceptions of benefits, knowledge, and trust is critical to encouraging the use of QRIS among MSME customers. Although ease of use and security do not directly affect usage intentions, ensuring an easy user experience and providing security guarantees for MSME customers are still essential. This study contributes to the literature by increasing understanding of the factors driving QRIS adoption in SMEs. These findings can assist in developing effective strategies to increase the use of QRIS and the growth of the MSME sector, emphasizing benefits and advantages, increasing customer knowledge, and building trust in security.
Correlation of calcareous nannofossil zones to the local first occurrence of Pachydiscus neubergicus (von Hauer, 1858) (Ammonoidea) in European Upper Cretaceous sections

Abstract The first occurrence (FO) of the ammonite Pachydiscus neubergicus (von Hauer, 1858) has been correlated to calcareous nannofossil zonations in several European sections along the northern margin of the Tethyan palaeobiogeographic realm. Both the proposed stratotype section of Tercis (SW France) and complete, ammonite-bearing sections in northern Spain document the FO of P. neubergicus within standard nannofossil zone CC23a (UC16), below the LO of Broinsonia parca constricta. Other sections such as the type locality Neuberg (Austria), Nagoriani (the Ukraine) and Bjala (Bulgaria) indicate considerable diachroneity of local FOs and show P. neubergicus to range up to nannofossil zone CC25b/c (UC20; Late Maastrichtian).
Counteracting Workplace Bullying: A Qualitative Analysis of Employees’ Resistance Strategies Within the Service Industry

This paper reviews employees’ resistance strategies to workplace bullying. The paper integrates the theoretical philosophies of Foucault’s (1977, 1982) power discourses, Scott’s (1985) resistance ideologies, and thirty-five in-depth interviews with employees working within the service sector, specifically, a college, motel, non-profit organization, and hospitals. The victims’ responses are thematically analyzed using a dialectic phenomenology paradigm to reveal a series of resistance responses ranging from retaliating, ignoring, quitting, avoiding, and successfully implementing anti-bullying interventions. In addition, interesting insights are proven on the detrimental impact of even non-confrontational resistance actions of employees to organizations. This study reinforces the importance of designing zero-tolerance bullying workplaces regardless of the products manufactured or services offered.
Relationship between nurses' perceptions of distance in-service training activities and job motivations

Background: The use of innovative technologies in continuing education activities in nursing is important in terms of increasing the quality of care. Aim: This study aimed to determine the relationship between nurses’ perceptions of distance in-service training and job motivations. Study Design: This study was designed as descriptive and correlational. Methods:. This study population consisted of nurses working in rooted education-research and state hospitals that continue distance in-service training activities. The study were conducted an 703 nurses between October 2020 and January 2021. Data were collected with the “Information Form”, the “Distance In-Service Training Perception Scale” and the “Nurse Job Motivation Scale”. Findings: The nurses’ total mean scale scores were 3.21±. 97 for the “Distance In-Service Training Perception Scale” and 59.98±10.01 for the “Nurse Job Motivation Scale”. This showed that the nurses’ perception towards distance in-service training and job motivations were positively above the average. Nurses’ perception towards distance in-service training and job motivations were affected by gender, marital status, education level, type of institution, work years, type of employment, way of working, unit and choosing the profession and unit willingly. The nurses’ perception towards distance in-service training weren’t affected by distance or face-to-face education methods. It was determined that there was a weak positive relationship and a statistically highly significant relationship between the nurses’ perception towards distance in-service training activities and job motivations. Conclusion: It is thought that the use of innovative teaching methods and materials in continuing training activities will contribute to the continuity of professional development and to increase job motivations.
Follow-up for More than 10 Years of Patients with Peritoneal Metastases Treated with Cytoreductive Surgery + Hyperthermic Intraperitoneal Chemotherapy in a Specialized Unit

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have demonstrated their impact on disease-free survival (DFS) and overall survival (OS) of patients with peritoneal metastases (PM). However, prior literature lacks evidence regarding any follow-up beyond 5 years. In this study, we analyse long-term OS and DFS (more than 10 years of follow-up) of patients undergoing CRS + HIPEC in a specialized unit. We conducted a retrospective study that included only patients who underwent CRS + HIPEC from January 2001 to May 2012. Data collection was conducted by reviewing medical records and telephone calls to patients or relatives. A total of 86 patients were included. The mean PCI was nine (range 0–39) and complete cytoreduction (CC-0) was reached in 80% of patients. Postoperative complications Clavien–Dindo III-IV occurred in 27.9% of patients and the 30-day mortality rate was 2.3%. After 10 years of actual follow-up, OS was 33.7% and DFS was 31.4%. Considering the historical context in which the standard of care for patients with PM was palliation, the results obtained show that CRS + HIPEC was a valid option, with morbimortality comparable to other major abdominal surgeries and encouraging survival results, since, after 10 years of follow-up, almost one-third of patients are still alive and disease-free.
Etnogénesis del País Vasco: de los antiguos mitos a la investigación actual 1 Analysis of Basque Protohistory: from Old Myths to Recent Data

The origin of Basque people is a myth based on biblical conceptions, previous to the rising of scientific Prehistory. An analysis of the formation of Old Basque Populations based on recent data proves that Barduli, Caristi and Autrigones were Indo-Europeans peoples in their culture, language and mentality, with possible cases of inter-ethnicity with some minorities of Basque origin. Basque peoples must be related to the old Vascones, extended Eastwards from Leizaran River and in the Pyrenean Range until Huesca and the Aquitania, western from Garone River. LABURPENA Euskaldunen jatorriaren "antzinatasuna" Historiaurrea zientzia bezala sortu baino lehen Biblian oinarriturik eratutako mito historiografikoa da. Gaur egun eskura dauden datuetan oinarriturik esan daiteke Euskal Erkidegoaren etnogenesiak adierazten duenez, egungo Euskal Erkidegoan bizi diren herriak (barduliarrak, karistiarrak eta autrigoiak) indoeuroparrak zirela bai kultura, hizkuntza eta ideologiagatik; alabaina ho- rrek ez du esanahi baskoiekin, maila apalean bada ere, etnia kidetasun fenomeno batzuk gertatuko ez zirenik. Orain arteko uste batzuen kon- tra beraz, euskal elementu linguistikoek edo euskaldunak deitzen zaienek Baskoiekin dute zerikusi. Herrialde hori Leizaran ibaiaren ekialdean zehar eta Pirinioetan zehar Huescaraino edota zertxobait ekialderago hedatzen zen, baita Akitanian zehar ere, Garona ibaiaren mendebaldean zehar.
Association between hiatal hernia and Barrett’s esophagus: an updated meta-analysis with trial sequential analysis

Background: Barrett’s esophagus (BE) is a precursor of esophageal adenocarcinoma. It is critical to recognize the risk factors associated with BE. Objectives: The present meta-analysis aims to systematically estimate the association of hiatal hernia with the risk of BE. Design: A meta-analysis with trial sequential analysis. Data sources and methods: The PubMed, EMBASE, and Cochrane Library databases were searched. The pooled odds ratios (ORs) and adjusted ORs (aORs) with their 95% confidence intervals (CIs) were calculated for the combined estimation of unadjusted data and data adjusted for confounders, respectively. Heterogeneity was quantified using the Cochrane Q test and I² statistics. Subgroup, meta-regression, and leave-one-out sensitivity analyses were employed to explore the sources of heterogeneity. Results: Forty-seven studies with 131,517 participants were included. Based on the unadjusted data from 47 studies, hiatal hernia was significantly associated with an increased risk of any length BE (OR = 3.91, 95% CI = 3.31–4.62, p < 0.001). The heterogeneity was significant (I² = 77%; p < 0.001) and the definition of controls (p = 0.014) might be a potential contributor to heterogeneity. Based on the adjusted data from 14 studies, this positive association remained (aOR = 3.26, 95% CI = 2.44–4.35, p < 0.001). The heterogeneity was also significant (I² = 65%; p < 0.001). Meta-analysis of seven studies demonstrated that hiatal hernia was significantly associated with an increased risk of long-segment BE (LSBE) (OR = 10.01, 95% CI = 4.16–24.06, p < 0.001). The heterogeneity was significant (I² = 78%; p < 0.001). Meta-analysis of seven studies also demonstrated that hiatal hernia was significantly associated with an increased risk of short-segment BE (OR = 2.76, 95% CI = 2.05–3.71, p < 0.001). The heterogeneity was not significant (I² = 30%; p = 0.201). Conclusion: Hiatal hernia should be a significant risk factor for BE, especially LSBE. Registration: PROSPERO registration number CRD42022367376.
Organizational support and task performance: a multiple mediation model

Objective Organizational support has been identified as one of the causes for task performance, while previous studies have not adequately explored the underlying mechanisms. Thus, this study aims to reveal the potential mechanisms that linked organizational support to task performance. Methods A questionnaire survey was conducted among the 720 participants from 12 audit firms in Beijing in December 2020. Participants completed anonymous questionnaires assessing their organizational support, task performance, organizational commitment, and job satisfaction. Data analysis was conducted with SPSS 26.0. Results (1) Organizational support was positively associated with task performance, (2) job satisfaction and organizational commitment both mediated the relationship between organizational support and task performance respectively, and (3) the relationship between organizational support and task performance was also serially mediated by job satisfaction and then organizational commitment. Conclusion Job satisfaction and organizational commitment played a serial multiple mediating role in the association between organizational support and task performance, which provides a potential path for improving task performance.
Suitability analysis of spiny lobster mariculture zones in Sabang waters, Indonesia

The lobster aquaculture industry has a high dependence on natural catch. Hence, lobster farming has become necessary. The waters in Sabang have the potential for developing lobster mariculture, but data is not yet available on the conditions of the aquatic environment that are suitable for lobster farming. This research aims to determine which locations are suitable for lobster mariculture activities in the waters of Sabang. The research parameters are divided into geographics, physicochemical, and supporting parameters. The geographical parameters group was collected through in-situ observations, and physicochemical parameters were measured in-situ and laboratory tests, supporting parameters through observations. Initial data analysis used the SAW (Simple Additive Weighting), AHP (Analysis Hierarchy Process) methods, and spatial analysis to determine the suitability of lobster cultivation zones with the Geographic Information System (GIS). From the observations of geographical parameters, the three locations of the observation station were in the very suitable category. The results of measuring physicochemical parameters group in three research locations were very suitable. Based on observations of other supporting parameters, Lhok Krueng Raya is very suitable for the cultivation zone, while Teupin Sirui and Lhok Weing are suitable. The findings of this research indicate that location protection, accessibility, DO, and COD are limiting parameters for selecting a suitable location for lobster mariculture in Sabang waters.Keywords:Suitability analysisLobster farmingSabangGIS
Association of heat-shock protein 70.1 gene with physiological and physical performance of Bali cattle

Background and Aim: Global warming challenges cattle productivity and welfare since it affects heat stress and scarce feed. The heat-shock protein 70 (HSP70) gene is essential in cytoprotection against stressors, protecting cells from dysregulated gene expression and apoptosis. This study aimed to identify significant genetic markers of the HSP70.1 gene that can be leveraged genetically to enhance thermotolerance and production in Bali cattle further. Materials and: Methods: Animals were sampled from three different rearing systems. In this study, 83 healthy adult male Bali cattle without abnormalities were utilized. Single-nucleotide polymorphism (SNP) diversity associated with the physiological and physical traits of Bali cattle was assessed using SNPStat online software. Gene expression for putative SNPs and their genotypic groups was further evaluated. Results: There were 15 polymorphic SNPs (c.-185G>A, c.-69T>G, c.10G>C, c.19A>G, c.45C>T, c.101INS, c.115T>C, c.130T>C, c.136G>T, c.159G>C, c.164G>T, c.234G>A, c.303G>A, c.333C>A, and c.456C>T) identified, of which 12 were associated with the assessed trait. Nine SNPs were associated with physiological traits, while eight were with physical traits. The c.136G>T as a novel, high minor allele frequency, and associative SNP was selected for HSP70 gene expression. Individuals with the TT genotype have a trim physique, susceptible physiology, and high HSP70 mRNA expression. On the other hand, the GG genotype was significantly associated with larger physique, lower physiology, and low HSP70 mRNA expression. The higher expression may indicate that HSP70.1 is involved in mitigating the deleterious effects of stress. As a result, the animal experienced negative energy balance, decreasing body size. Conclusion: Single-nucleotide polymorphism c.136G>T is a candidate biomarker for heat resistance traits in Bali cattle.
A Review of Dielectric Barrier Discharge Cold Atmospheric Plasma for Surface Sterilization and Decontamination

Numerous investigations have shown that nonequilibrium discharges at atmospheric pressure, also known as “cold atmospheric plasma” (CAP), are efficient to remove biological contaminants from surfaces of a variety of materials. Recently, CAP has quickly advanced as a technique for microbial cleaning, wound healing, and cancer therapy due to the chemical and biologically active radicals it produces, known collectively as reactive oxygen and nitrogen species (RONS). This article reviews studies pertaining to one of the atmospheric plasma sources known as dielectric barrier discharge (DBD) which has been widely used to treat materials with microbes for sterilization, disinfection, and decontamination purposes. To advance research in CAP applications, this review discusses various types and configurations of barrier discharge, the role played by reactive species and other DBD-CAP agents leading to its antimicrobial efficacy, a few collection of DBD-CAP past studies specifically on surface, and emerging applications of DBD-CAP technology. Our review showed that nonthermal/equilibrium plasma generated from DBD could sterilize or disinfect surface of materials without causing any thermal damage or environmental contamination.