Miracle-dz/UniFAR-FTUs huggingface dataset:
Tactile Perception Technologies and Their Applications in Minimally Invasive Surgery: A Review

Minimally invasive surgery (MIS) has been the preferred surgery approach owing to its advantages over conventional open surgery. As a major limitation, the lack of tactile perception impairs the ability of surgeons in tissue distinction and maneuvers. Many studies have been reported on industrial robots to perceive various tactile information. However, only force data are widely used to restore part of the surgeon’s sense of touch in MIS. In recent years, inspired by image classification technologies in computer vision, tactile data are represented as images, where a tactile element is treated as an image pixel. Processing raw data or features extracted from tactile images with artificial intelligence (AI) methods, including clustering, support vector machine (SVM), and deep learning, has been proven as effective methods in industrial robotic tactile perception tasks. This holds great promise for utilizing more tactile information in MIS. This review aims to provide potential tactile perception methods for MIS by reviewing literatures on tactile sensing in MIS and literatures on industrial robotic tactile perception technologies, especially AI methods on tactile images.
Endothelium-Derived Hyperpolarizing Factor and Myoendothelial Coupling: The in vivo Perspective

The endothelium controls vascular tone adopting blood flow to tissue needs. It releases chemical mediators [e.g., nitric oxide (NO), prostaglandins (PG)] and exerts appreciable dilation through smooth muscle hyperpolarization, thus termed endothelium-dependent hyperpolarization (EDH). Initially, EDH was attributed to release of a factor, but later it was suggested that smooth muscle hyperpolarization might be derived from radial spread of an initial endothelial hyperpolarization through heterocellular channels coupling these vascular cells. The channels are indeed present and formed by connexins that enrich in gap junctions (GJ). In vitro data suggest that myoendothelial coupling underlies EDH-type dilations as evidenced by blocking experiments as well as simultaneous, merely identical membrane potential changes in endothelial and smooth muscle cells (SMCs), which is indicative of coupling through ohmic resistors. However, connexin-deficient animals do not display any attenuation of EDH-type dilations in vivo, and endothelial and SMCs exhibit distinct and barely superimposable membrane potential changes exerted by different means in vivo. Even if studied in the exact same artery EDH-type dilation exhibits distinct features in vitro and in vivo: in isometrically mounted vessels, it is rather weak and depends on myoendothelial coupling through connexin40 (Cx40), whereas in vivo as well as in vitro under isobaric conditions it is powerful and independent of myoendothelial coupling through Cx40. It is concluded that EDH-type dilations are distinct and a significant dependence on myoendothelial coupling in vitro does not reflect the situation under physiologic conditions in vivo. Myoendothelial coupling may act as a backup mechanism that is uncovered in the absence of the powerful EDH-type response and possibly reflects a situation in a pathophysiologic environment.
Working Memory in Aphasia: The Role of Temporal Information Processing

Aphasia is an acquired impairment of language functions resulting from a brain lesion. It is usually accompanied by deficits in non-linguistic cognitive processes. This study aimed to investigate in patients with aphasia the complex interrelationships between selected cognitive functions: auditory speech comprehension, working memory (WM), and temporal information processing (TIP) in the millisecond time range. Thirty right-handed subjects (20 males) aged from 27 to 82 years suffering from post-stroke aphasia participated in the study. Verbal working memory (VWM) and spatial working memory (SWM) were assessed with: (1) a receptive verbal test and (2) the Corsi Block-Tapping Test, respectively. Both these WM tests used the forward tasks (mainly engaging maintenance processes, i.e., storing, monitoring, and matching information) and backward tasks (engaging both maintenance and manipulation processes, i.e., reordering and updating information). Auditory comprehension was assessed by receptive language tests, and TIP efficiency was assessed by auditory perception of temporal order in the millisecond time range. We observed better performance of forward WM tasks than backward ones, independently of the type of material used. Furthermore, the severity of auditory comprehension impairment correlated with the efficiency on both forward and backward VWM tasks and the backward SWM task. Further analysis revealed that TIP plays a crucial role only in the latter task. These results indicate the divergent pattern of interactions between WM and TIP depending on the type of WM tasks. Level of verbal competency appeared to play an important role in both VWM tasks, whereas TIP (which is associated with manipulation processes) appeared to be important for SWM, but only on the backward task.
The Role of Personal and Political Values in Predicting Environmental Attitudes and Pro-environmental Behavior in Kazakhstan

Although it is widely accepted that personal values of Self-Transcendence are a positive predictor of environmentalism, and Self-Enhancement values are a negative one, these results are not conclusive for all cultural contexts. Regarding political ideologies, research concludes that liberals tend to be more concerned about the environment than conservatives. However, this two-dimensional take on political ideologies does not grasp the diversity of political views, which could be achieved by focusing on political values. In this research, we studied the role of personal and political values in predicting environmental attitudes and behavior in Kazakhstan, a developing country in Central Asia. Using an online survey (n = 305), we found that Security was a strong predictor of both environmental concern and New Environmental Paradigm (NEP), overshadowing the effect of traditionally accepted value dimensions of Self-Transcendence and Self-Enhancement. While Self-Direction positively predicted environmental concern, Universalism and Benevolence were positive predictors of NEP. Among political values, Civil Liberties predicted NEP positively, and had no significant effect on environmental concern, while Free Enterprise predicted environmental concern negatively, and had no significant effect on NEP. Environmental concern was a strong predictor of all pro-environmental behaviors included in the study (littering, recycling, environmental citizenship, and community action), fully mediating the effect of NEP. Based on personal and political values, three profiles of Kazakhstanis who engaged differently in pro-environmental behavior were identified.
Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma

Background Immunotherapy and sorafenib exert anti-tumor effects via ferroptosis, but reliable biomarkers for the individual treatment and prognosis prediction of hepatocellular carcinoma (HCC) based on the ferroptosis and immune status remain lacking. Methods Ferroptosis-related genes (FRGs) were identified by downloading data from FerrDb and by searching and reading original articles from PubMed. Immune-related genes (IRGs) were downloaded from ImmPort. Prognostic FRGs and IRGs in the GSE14520 (n = 220) and The Cancer Genome Atlas (TCGA, n = 365) datasets were identified. Least absolute shrinkage and selection operator (LASSO) Cox regression and multivariate Cox regression were used for model construction. Ferroptosis expression profiles, the infiltration of immune cells, and the somatic mutation status were analyzed and compared. Results Twenty-seven prognostic ferroptosis- and immune-related signatures were included to construct a comprehensive index of ferroptosis and immune status (CIFI). A subgroup of patients was identified as having a high CIFI value, which was associated with a worse prognosis. This subgroup of patients had significantly up-regulated expressions of many suppressors of ferroptosis and higher fractions of immunosuppressive cells, such as cancer-associated fibroblasts (CAFs) and myeloid-derived suppressor cells (MDSCs). Notably, somatic mutation analysis indicated that high-CIFI patients had higher levels of tumor heterogeneity and higher mutation frequencies of genes like TP53. Conclusion In this work, a novel prognostic classifier was developed based on ferroptosis- and IRGs in HCC, and this classifier could be used for prognostic prediction and the selection of patients for immunotherapies and targeted therapies.
Influence of pH and temperature on Cr(VI) removal from a natural water using Fe(II): A pilot and full scale case study

Aqueous Cr(VI) removal using Fe(II) was studied in a natural water as a function of temperature and pH, in kinetic batch experiments and also in a pilot and a full scale study. Temperature and pH strongly influenced the reduction of Cr(VI) by Fe(II). The reaction rate was increased by increasing pH in the range between 6 and 8 commonly encountered in natural waters. At 25°C and pH values higher than 7, maximum Cr(VI) removal was achieved at a reaction time equal or less than 5 min. The reaction followed a second order rate equation {–d[Cr(VI)]/dt = k obs[Cr(VI)] [Fe(II)][Cr(VI)]} with k obs [Cr(VI)] ≥ 1×104 M–1s–1. Reaction rate was also increased by increasing temperature from 10°C to 40°C, confirming the endothermic character of the reaction. Dissolved oxygen strongly competed with Cr(VI) in Fe(II) oxidation and batch experiments showed an increase of the reaction ratio [Fe(II)]/[Cr(VI)] from the almost stoichiometric value 3.1 at pH 6 to 25 at pH 8. These reaction ratio values were also verified by the.
Assessment of Depression Severity During Coronavirus Disease 2019 Pandemic Among the Palestinian Population: A Growing Concern and an Immediate Consideration

Background: Aggressive quarantine and lockdown measures were implemented as protective public health actions during the coronavirus disease 2019 (COVID-19) pandemic. Assessing the psychological effects associated with these measures is an important attempt to inform local policymakers in an early stage. Yet little is known about these effects, specifically depression, among the Palestinians. This study aimed to assess the prevalence and predictors of depression among the Palestinian community during this pandemic. Materials and methods: A cross-sectional web-based survey throughout social media (Facebook and Instagram) was carried out using an anonymous online questionnaire. The validated and standardized depression, anxiety, and stress scale (DASS) was used to measure depression severity. A snowball technique recruiting the general public living in Palestine was conducted. Data were collected between 6 and 16 April 2020, which corresponded to the middle interval of strict massive lockdown in Palestine on 22 March to 5 May 2020. Multinomial logistic regression model was developed to predict depression severity. Results: About 2,819 respondents filled out the questionnaire. Depression prevalence was (57.5%; n = 1,621). Out of them, 66% had mild/moderate severity, and 34% had severe/extremely severe degree. Depression severity was negatively associated with age {mild/moderate degree [OR (95% CI) = 0.98 (0.97–0.99)] and severe/extremely severe [OR (95% CI) = 0.96 (0.94–0.97)]} degrees compared with normal degree. Males were significantly less likely to have higher depression than females {mild/moderate degree [OR (95% CI) = 0.69 (0.57–0.85)] and severe/extremely severe [OR (95% CI) = 0.52 (0.40–0.86)]} degree. However, those who reported having inadequate food supply and lesser monthly incomes were more likely to have a higher degree of depression as compared with normal degree. Single persons were significantly more likely to have mild/moderate depression than those in a relationship [OR (95% CI) = 1.31 (1.05–1.64)]. Conclusions: High depression prevalence (57.5%) among the Palestinian community during the COVID-19 pandemic is a growing public health concern. It is essential to provide psychological counseling and treatment during and after the pandemic for the targeted people at high risk (young age/female gender) who were affected psychologically. Strategic long-term policy to address pandemic ramifications, including depression, by implementing comprehensive interventions taking into account socioeconomic disparities, vulnerability, and inequities, is crucial to emerge from this crisis in Palestine.
Geological and Geophysical Factors Constraining the Occurrence of Earthquake Precursors in Geofluids: A Review and Reinterpretation

In this paper, we update the previous compilations of observed earthquake precursors from the published scientific literature of the last decade. We collected the epicentral coordinates, magnitude, hypocentral depth of each earthquake and the distance from the observed precursor and its time lag. The locations are reported and compared with data concerning geological and geophysical parameters like global seismicity, volcanic locations, heat flow and tectonic regimes. Possible relations between geological and geophysical parameters and the occurrence of fluid-related earthquake precursors are considered and discussed. Some geological and geophysical conditions can be deemed responsible for the occurrence of fluid-related earthquake precursory phenomena. Geophysical models used to explain the occurrence of earthquake precursors are discussed with the purpose of contributing to engineering proper monitoring networks. Areas of the world potentially suitable for earthquake fluid-related precursor monitoring are suggested.
Moving Biofortified Cassava Products Closer to Market in Nigeria

Food must be acceptable, affordable, and available to consumers and consumers must have the resources, knowledge, and correct mindset to purchase and consume these foods. The narrative of this study centered on moving biofortified food closer to market by looking at awareness, adoption, and consumer mindsets as pillars to achieve market access. Our findings show that in Abia state, Nigeria, consumers are aware of biofortified cassava. This signifies a high market potential and economic opportunity for stakeholders in the supply chain. Unfortunately, consumers lack understanding of biofortified cassava's nutrition value. The high adoption level of biofortified cassava has implications on investment and stimulation of the local economy. The study identified accessibility, purposefulness and innovation as vital mindset drivers to scale market demand, and factors that affect both consumption, production, and marketing of the product. This study provides insight regarding potential priority areas of action for government policy interventions to stimulate demand and supply opportunities. This study also provides evidence that scaling up demand will depend on awareness creation. There is a need to improve communication networks to provide overwhelming product acceptance, adoption, and consumption of biofortified cassava. This will help change remaining myths about agro-biotechnology and the bioeconomy.
Molecular Epidemiology and Risk Factors of Clostridium difficile ST81 Infection in a Teaching Hospital in Eastern China

Background The prevalence of Clostridium difficile causes an increased morbidity and mortality of inpatients, especially in Europe and North America, while data on C. difficile infection (CDI) are limited in China. Methods From September 2014 to August 2019, 562 C. difficile isolates were collected from patients and screened for toxin genes. Multilocus sequence typing (MLST) and antimicrobial susceptibility tests by E-test and agar dilution method were performed. A case group composed of patients infected with sequence type (ST) 81 C. difficile was compared to the non-ST81 infection group and non CDI diarrhea patients for risk factor and outcome analyses. Results The incidence of inpatients with CDI was 7.06 cases per 10,000 patient-days. Of the 562 C. difficile isolates, ST81(22.78%) was the predominant clone over this period, followed by ST54 (11.21%), ST3 (9.61%), and ST2 (8.72%). Toxin genotype tcdA+tcdB+cdt- accounted for 50.18% of all strains, while 29.54% were tcdA-tcdB+cdt- genotypes. Overall, no isolate was resistant to vancomycin, teicoplanin or daptomycin, and resistance rates to meropenem gradually decreased during these years. Although several metronidazole-resistant strains were isolated in this study, the MIC values decreased during this period. Resistance rates to moxifloxacin and clindamycin remained higher than those to the other antibiotics. Among CDI inpatients, longer hospitalization, usage of prednisolone, suffering from chronic kidney disease or connective tissue diseases and admission to emergency ward 2 or emergency ICU were significant risk factors for ST81 clone infection. All-cause mortality of these CDI patients was 4.92%(n=18), while the recurrent cases accounted for 5.74%(n=21). The 60-day mortality of ST81-CDI was significantly higher than non-ST81 infected group, while ST81 also accounted for most of the recurrent CDI cases. Conclusion This study revealed the molecular epidemiology and risk factors for the dominant C. difficile ST81 genotype infection in eastern China. Continuous and stringent surveillance on the emerging ST81 genotype needs to be initiated.
The Performance of Olfactory Receptor Neurons: The Rate of Concentration Change Indicates Functional Specializations in the Cockroach Peripheral Olfactory System

Slow and continuous changes in odor concentration were used as a possible easy method for measuring the effect of the instantaneous concentration and the rate of concentration change on the activity of the olfactory receptor neurons (ORNs) of basiconic sensilla on the cockroach antennae. During oscillating concentration changes, impulse frequency increased with rising instantaneous concentration and this increase was stronger the faster concentration rose through the higher concentration values. The effect of the concentration rate on the ORNs responses to the instantaneous concentration was invariant to the duration of the oscillation period: shallow concentration waves provided by long periods elicited the same response to the instantaneous concentration as steep concentration waves at brief periods. Thus, the double dependence remained unchanged when the range of concentration rates varied. This distinguishes the ORNs of basiconic sensilla from those of trichoid sensilla (Tichy and Hellwig, 2018) which adjust their gain of response according to the duration of the oscillating period. The precision of the ORNs to discriminate increments of slowly rising odor concentration was studied by applying gradual ramp-like concentration changes at different rates. While the ORNs of the trichoid sensilla perform better the slower the concentration rate, those of the basiconic sensilla show no preference for a specific rate of concentration increase. This suggests that the two types of sensilla have different functions. The ORNs of the trichoid sensilla may predominately analyze temporal features of the odor signal and the ORNs of the basiconic sensilla may be involved in extracting information on the identity of the odor source instead of mediating the spatial-temporal concentration pattern in an odor plume.
Less Is More—Cyclists-Triathlete’s 30 min Cycling Time-Trial Performance Is Impaired With Multiple Feedback Compared to a Single Feedback

Purpose: The purpose of this article was to (i) compare different modes of feedback (multiple vs. single) on 30 min cycling time-trial performance in non-cyclist’s and cyclists-triathletes, and (ii) investigate cyclists-triathlete’s information acquisition. Methods: 20 participants (10 non-cyclists, 10 cyclists-triathletes) performed two 30 min self-paced cycling time-trials (TT, ∼5–7 days apart) with either a single feedback (elapsed time) or multiple feedback (power output, elapsed distance, elapsed time, cadence, speed, and heart rate). Cyclists-triathlete’s information acquisition was also monitored during the multiple feedback trial via an eye tracker. Perceptual measurements of task motivation, ratings of perceived exertion (RPE) and affect were collected every 5 min. Performance variables (power output, cadence, distance, speed) and heart rate were recorded continuously. Results: Cyclists-triathletes average power output was greater compared to non-cyclists with both multiple feedback (227.99 ± 42.02 W; 137.27 ± 27.63 W; P < 0.05) and single feedback (287.9 ± 60.07 W; 131.13 ± 25.53 W). Non-cyclist’s performance did not differ between multiple and single feedback (p > 0.05). Whereas, cyclists-triathletes 30 min cycling time-trial performance was impaired with multiple feedback (227.99 ± 42.02 W) compared to single feedback (287.9 ± 60.07 W; p < 0.05), despite adopting and reporting a similar pacing strategy and perceptual responses (p > 0.05). Cyclists-triathlete’s primary and secondary objects of regard were power (64.95 s) and elapsed time (64.46 s). However, total glance time during multiple feedback decreased from the first 5 min (75.67 s) to the last 5 min (22.34 s). Conclusion: Cyclists-triathletes indoor 30 min cycling TT performance was impaired with multiple feedback compared to single feedback. Whereas non-cyclist’s performance did not differ between multiple and single feedback. Cyclists-triathletes glanced at power and time which corresponds with the wireless sensor networks they use during training. However, total glance time during multiple feedback decreased over time, and therefore, overloading athletes with feedback may decrease performance in cyclists-triathletes.
The Role of HLA-G in Tumor Escape: Manipulating the Phenotype and Function of Immune Cells

Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class I (MHC I) molecule, and under physiological conditions, its expression is strictly restricted to the maternal–fetal interface and immune-privileged organs where HLA-G is expected to contribute to establishment and maintenance of immune tolerance. However, the expression of HLA-G has been found in various types of tumors, and the level of its expression frequently correlates with high-grade histology and poor prognosis, raising the possibility that it may play a negative role in tumor immunity. ILT2 and ILT4, present on a broad of immune cells, have been identified as the main receptors engaging HLA-G, and their interactions have been found to allow the conversion of effectors like NK cells and T cells to anergic or unresponsive state, activated DCs to tolerogenic state, and to drive the differentiation of T cells toward suppressive phenotype. Therefore, tumors can employ HLA-G to modulate the phenotype and function of immune cells, allowing them to escape immune attack. In this review, we discuss the mechanism underlying HLA-G expression and function, its role played in each step of the tumor-immunity cycle, as well as the potential to target it for therapeutic benefit.