Miracle-dz/UniFAR-FTUs huggingface dataset:
Inequality in electricity consumption and economic growth: Evidence from a small area estimation study

Our study uses a small area estimation method to estimate the average and inequality of per capita kWh consumption for small areas in Vietnam. It shows evidence of a large spatial heterogeneity in the electric power consumption between districts and provinces in Vietnam. Households in the mountains and highlands consumed remarkably less electricity than those in the delta and coastal areas. Notably, we find a U-shaped relationship between the inequality of electricity consumption and economic levels in Vietnam. In poor districts and provinces, there is very high inequality in electricity consumption. Inequality is lower in middle-income districts and provinces.
Daily Artificial Gravity Partially Mitigates Vestibular Processing Changes Associated with Head-down Tilt Bedrest

Microgravity alters vestibular signaling and reduces body loading, driving sensory reweighting and adaptation. The unloading effects can be modelled using head down tilt bedrest (HDT). Artificial gravity (AG) has been hypothesized to serve as an integrated countermeasure for the physiological declines associated with HDT and spaceflight. Here, we examined the efficacy of 30 minutes of daily AG to counteract brain and behavior changes that arise from 60 days of HDT. One group of participants received 30 minutes of AG daily (AG; n = 16) while in HDT, and another group served as controls, spending 60 days in HDT bedrest with no AG (CTRL; n = 8). We examined how HDT and AG affect vestibular processing by collecting fMRI scans from participants as they received vestibular stimulation. We collected these data prior to, during (2x), and post HDT. We assessed brain activation initially in 10 regions of interest (ROIs) and then conducted an exploratory whole brain analysis. The AG group showed no changes in brain activation during vestibular stimulation in a cerebellar ROI, whereas the CTRL group showed decreased cerebellar activation specific to the HDT phase. Additionally, those that received AG and showed little pre- to post-bed rest changes in left OP2 activation during HDT had better post-HDT balance performance. Exploratory whole brain analyses identified increased pre- to during-HDT activation in the CTRL group in the right precentral gyrus and the right inferior frontal gyrus specific to HDT, where the AG group maintained pre-HDT activation levels. Together, these results indicate that AG could mitigate brain activation changes in vestibular processing in a manner that is associated with better balance performance after HDT.
NIH funding for patents that contribute to market exclusivity of drugs approved 2010–2019 and the public interest protections of Bayh-Dole

Previous studies have shown that National Institutes of Health (NIH) funding contributed >$187 billion for basic or applied research related to the 356 drugs approved 2010–2019. This analysis asks how much of this funding led to patents cited as providing market exclusivity, patents that would be subject to the provisions of the Bayh-Dole Act that promote and protect the public interest. The method involves identifying published research in PubMed related to the approved drugs (applied research) or their targets (basic research). NIH-funded projects (grants) funding these publications and patents arising from these projects were both identified in RePORT. Patents cited as providing market exclusivity were identified in DrugPatentWatch (which incorporates FDA Orange Book). NIH funded basic or applied research related to all 313 FDA-approved drugs 2010–2019 with at least one patent in DrugPatentWatch. This research comprised 350 thousand publications (9% applied research; 91% basic research) supported by 341 thousand fiscal years (project years) of NIH funding and $164 billion in NIH project year costs (17% applied research; 83% basic research). These NIH projects also produced 22,360 patents, 119 of which were cited in DrugPatentWatch as protecting 34/313 drugs. These patents were associated with 769 project years of NIH funding (0.23% total) and project year costs of $0.95 billion (0.59% total). Overall, only 1.5% of total NIH funding for applied research and 0.38% of total NIH funding for basic research was associated with patents in DrugPatentWatch. This analysis shows that very little of the NIH funding for research that contributes to new drug approvals leads to patents that provide market exclusivity and are subject to the provisions of the Bayh-Dole Act that promote the public interest in practical applications of the research, reasonable use and pricing, and a return on this public sector investment. This suggests that the Bayh-Dole Act is limited in its ability to protect the public interest in the pharmaceutical innovations driven by NIH-funded research.
Feeding the fever: Complex host‐pathogen dynamics along continuous resource gradients

Abstract Food has long been known to perform dual functions of nutrition and medicine, but mounting evidence suggests that complex host‐pathogen dynamics can emerge along continuous resource gradients. Empirical examples of nonmonotonic responses of infection with increasing host resources (e.g., low prevalence at low and high resource supply but high prevalence at intermediate resources) have been documented across the tree of life, but these dynamics, when observed, often are interpreted as nonintuitive, idiosyncratic features of pathogen and host biology. Here, by developing generalized versions of existing models of resource dependence for within‐ and among‐host infection dynamics, we provide a synthetic view of nonmonotonic infection dynamics. We demonstrate that where resources jointly impact two (or more) processes (e.g., growth, defense, transmission, mortality, predation), nonmonotonic infection dynamics, including alternative states, can emerge across a continuous resource supply gradient. We review the few empirical examples that concurrently measured resource effects on multiple rates and pair this with a wide range of examples in which resource dependence of multiple rates could generate nonmonotonic infection outcomes under realistic conditions. This review and generalized framework highlight the likely generality of such resource effects in natural systems and point to opportunities ripe for future empirical and theoretical work.
The association of women’s experience of abuse in childhood with depression during pregnancy and the role of emotional support as a moderator

Background This study aimed to examine the prevalence of antenatal depression and experience of abuse during childhood, to analyze the association between having experienced childhood abuse and depression during pregnancy, and to explore the role of emotional support as a moderator of that association. Methods In total, 44,770 pregnant women were analyzed from the self-administered registry for risk assessment at community public health centers in Seoul, Republic of Korea, for home visiting service provision between 2015 and 2019. The Edinburgh Postnatal Depression Scale (EPDS) was applied for the assessment of depression. The adjusted effects of childhood abuse experience on antepartum depression according to emotional support as an effect moderator were estimated. Results Depression was present in 2,451 pregnant women (5.5%), and 1,506 (3.4%) reported having experienced physical, emotional, or sexual abuse in childhood. After adjustment of covariates, pregnant women who had experienced abuse during childhood had EPDS scores 2.79 points higher than pregnant women without such experiences, and those who lacked emotional support during adulthood had 4.96 points higher than their counterparts. The difference in EPDS scores based on childhood abuse experience among women who reported emotional support (2.86) was larger than the difference in EPDS scores among those with no emotional support (1.91) (P for interaction = 0.0106). Conclusions The experience of abuse in early life and emotional support in later life are both independently important for understanding antenatal depression in Korean women. More comprehensive emotional support is needed for pregnant women who experienced abuse in childhood.
“My brain freezes and I am blocked again”: The subjective experience of post-migration living difficulties influenced by complex posttraumatic stress disorder of Afghan asylum seekers and refugees in Austria

Background Potentially traumatic experiences and post-migration living difficulties (PMLDs) undoubtedly leave marks on mental health and psychosocial functioning. While PMLDs are recognised as a risk factor for posttraumatic stress disorder and complex posttraumatic stress disorder (described together here as C/PTSD), recent investigations have found that C/PTSD symptoms might also influence the experience of PMLDs. The subjective experience of and coping with PMLDs in the context of C/PTSD symptoms has not yet been explored. Methods Semi-structured, interpreter-assisted interviews exploring the subjective experience of post-migration living difficulties were conducted with treatment-seeking Afghan refugees and asylum seekers (N = 24) and transcribed verbatim. Participants were screened using the International Trauma Questionnaire (ITQ) and allocated to a C/PTSD group or non-C/PTSD group. We analysed the qualitative interviews using content analysis and then compared the results of the two groups. Results Over half of the participants (58.3%) met the criteria for C/PTSD. While the two groups addressed numerous similar themes, the C/PTSD group more frequently mentioned themes associated with C/PTSD symptoms (e.g., intrusions, avoidance, sleep disturbances, affective dysregulation) that influenced their responses to PMLDs. The non-C/PTSD group more often experienced positive emotions such as gratitude and optimism, and showed more active, solution-oriented behaviour as well as positive self-verbalisation. Conclusion To achieve a deeper understanding of PMLDs, post-traumatic psychopathology should be taken into account, as C/PTSD symptoms influence the experience of and coping with PMLDs. The specifics of individual experiences need to be considered in order to promote adaptive coping with PMLDs and to set individual trauma-focused and transdiagnostic treatment targets. In addition, psychological interventions should incorporate psychoeducation to improve the understanding of the impact of C/PTSD on the current experience of PMLDs.
Genomic alterations involved in fluoroquinolone resistance development in Staphylococcus aureus

Aim Fluoroquinolone (FQ) is a potent antibiotic class. However, resistance to this class emerges quickly which hinders its application. In this study, mechanisms leading to the emergence of multidrug-resistant (MDR) Staphylococcus aureus (S. aureus) strains under FQ exposure were investigated. Methodology S. aureus ATCC 29213 was serially exposed to ciprofloxacin (CIP), ofloxacin (OFL), or levofloxacin (LEV) at sub-minimum inhibitory concentrations (sub-MICs) for 12 days to obtain S. aureus -1 strains and antibiotic-free cultured for another 10 days to obtain S. aureus-2 strains. The whole genome (WGS) and target sequencing were applied to analyze genomic alterations; and RT-qPCR was used to access the expressions of efflux-related genes, alternative sigma factors, and genes involved in FQ resistance. Results A strong and irreversible increase of MICs was observed in all applied FQs (32 to 128 times) in all S. aureus-1 and remained 16 to 32 times in all S. aureus-2. WGS indicated 10 noticeable mutations occurring in all FQ-exposed S. aureus including 2 insdel mutations in SACOL0573 and rimI; a synonymous mutation in hslO; and 7 missense mutations located in an untranslated region. GrlA, was found mutated (R570H) in all S. aureus-1 and -2. Genes encoding for efflux pumps and their regulator (norA, norB, norC, and mgrA); alternative sigma factors (sigB and sigS); acetyltransferase (rimI); methicillin resistance (fmtB); and hypothetical protein BJI72_0645 were overexpressed in FQ-exposed strains. Conclusion The emergence of MDR S. aureus was associated with the mutations in the FQ-target sequences and the overexpression of efflux pump systems and their regulators.
Therapist perspectives on telehealth-based virtual reality exposure therapy

Virtual reality (VR) can enhance mental health care. In particular, the effectiveness of VR-based exposure therapy (VRET) has been well-demonstrated for treatment of anxiety disorders. However, most applications of VRET remain localized to clinic spaces. We aimed to explore mental health therapists’ perceptions of telehealth-based VRET (tele-VRET) by conducting semi-structured, qualitative interviews with 18 telemental health therapists between October and December 2022. Interview topics included telehealth experiences, exposure therapy over telehealth, perceptions of VR in therapy, and perspectives on tele-VRET. Therapists described how telehealth reduced barriers (88.9%, 16/18), enhanced therapy (61.1%, 11/18), and improved access to clients (38.9%, 7/18), but entailed problems with technology (61.1%, 11/18), uncontrolled settings (55.6%, 10/18), and communication di culties (50%, 9/18). Therapists adapted exposure therapy to telehealth by using online resources (66.7%, 12/18), preparing client expectations (55.6%, 10/18), and adjusting workflows (27.8%, 5/18). Most therapists had used VR before (72.2%, 13/18) and had positive impressions (55.6%, 10/18), but none had used VR clinically. In response to tele-VRET, therapists requested interactive session activities (77.8%, 14/18) and customizable interventions components (55.6%, 10/18). Concerns about tele-VRET included risks with certain clients (77.8%, 14/18), costs (50%, 9/18), side effects and privacy (22.2%, 4/18), and inappropriateness for specific forms of exposure therapy (16.7%, 3/18). These results show how designing for telehealth may extend VRET and can help inform collaborative development of health technologies.
Multidermatomal herpes zoster involving CN V3 and C2 territories with simultaneous vestibulocochlear deficit: A case report

Rationale: Herpes zoster is characterized by the presence of unilateral, localized vesicular rash in a dermatomal distribution. Although in most cases herpes zoster affects a single dermatome, multidermatomal involvement may occur in rare cases. Patient concerns: In this case report, we describe an immunocompetent patient with multidermatomal herpes zoster involving the cranial nerve (CN) V3 and C2 territories with simultaneous vestibulocochlear deficits. We demonstrate the results of temporal bone magnetic resonance imaging and discuss the pathophysiological mechanism of the patient’s characteristic clinical manifestation. Diagnoses: The diagnosis of multidermatomal herpes zoster involving CN V3 and C2 territories with simultaneous vestibulocochlear deficit was made. Vestibular function test and pure tone audiometry revealed ipsilateral vestibular impairment and hearing loss. Interventions: The patient was admitted for treatment with systemic steroids and antiviral agents. Outcomes: After treatment, vertigo and hearing loss improved, and the skin lesions healed well without scarrings. Lessons: Considering that the afferent sensory fibers of the CN V and C2 converge in the trigeminocervical nucleus, herpes zoster involving contiguous dermatomes of CN V3 and C2 in the patient may be explained by neural-to-neural spread. And considering that temporal bone magnetic resonance imaging revealed enhancement of the dura of the internal auditory canal without enhancement of CN VII or VIII, the vestibulocochlear deficits in the patient may be caused by inflammation of the inner ear transmitted via the cerebrospinal fluid.
Dog breeds and conformations in the UK in 2019: VetCompass canine demography and some consequent welfare implications

Introduction Growing concerns over health and welfare impacts from extreme phenotypes in dogs have created an urgent need for reliable demographic information on the national breed structures of dogs. Methods This study included all dogs under primary veterinary care in the UK during 2019 at practices participating in VetCompass. Demographic data on these dogs were analysed to report on the frequency of common breeds and also to report on conformation, bodyweight, sex and neuter associations with these breeds. Results The study included 2,237,105 dogs under UK veterinary care in 2019. Overall, 69.4% (n = 1,551,462) were classified as purebred, 6.7% (149,308) as designer-crossbred and 24.0% (536,335) as nondesigner-crossbred. Across 800 unique breed names, the most frequent breeds at any age were nondesigner-crossbred (n = 536,335, 24.0%), Labrador Retriever (154,222, 6.9%) and Jack Russell Terrier (101,294, 4.5%). Among 229,624 (10.3%) dogs aged under one year, the most frequent breeds were nondesigner-crossbred (n = 45,995, 20.0%), French Bulldog (16,036, 7.0%) and Cockapoo (14,321, 6.2%). Overall, based on breed characteristics, 17.6% (395,739) were classified as brachycephalic, 43.1% (969,403) as mesaticephalic and 8.3% (186,320) as dolichocephalic. Of 1,551,336 dogs that were classifiable based on breed, 52.6% (815,673) were chondrodystrophic. Of 1,462,925 dogs that were classifiable, there were 54.6% (n = 798,426) short haired, 32.6% (476,883) medium haired and 12.8% (186,934) long haired. Of 1,547,653 dogs that were classifiable for ear carriage, 24.5% (n = 379,581) were erect, 28.1% (434,273) were semi-erect, 19.7% (305,475) were v-shaped drop and 27.7% (428,324) were pendulous. Overall, there was a 1.09:1.00 ratio of male (n = 1,163,512; 52.2%) to female dogs (n = 1,067,552; 47.8%). Conclusions Health and welfare issues linked to popular breeds with extreme phenotypes suggest that there is much work to do to help owners to make more welfare-friendly decisions when choosing which type of dog to own.
Cognitive Mechanism of Language Transfer: Brain Potential Data Analysis in English Comprehension

This study examines the effects of the differences between the deep meaning of the native language and the target language on language transfer in the cognitive process of English understanding from the aspects of behavior and cranial nerves. The experimental results show that besides the approximations in linguistic typology that impacts the formation of the cognitive mechanism of foreign language learner in the target language, the deep meaning relationship between the native language and the target language is also an important factor affecting language transfer, which affects the formation of the cognitive mechanism of foreign language learners to the target language. Specifically, English errors with the same meaning as Chinese cause significant N400 effect, while the error sentences with different meaning from Chinese do not cause the same brain potential effect. This study, from the perspective of cognitive neuroscience, supports the interpretation of language transfer by cognitive theory.
Introducing independent patterns into the Stochastically Perturbed Parametrization Tendencies (SPPT) scheme

The Stochastically Perturbed Parametrization Tendencies (SPPT) scheme is used at weather and climate forecasting centres worldwide to represent model uncertainty that arises from simplifications involved in the parametrization process. It uses spatio‐temporally correlated multiplicative noise to perturb the sum of the parametrized tendencies. However, SPPT does not distinguish between different parametrization schemes, which do not necessarily have the same error characteristics. A generalization to SPPT is proposed, whereby the tendency from each parametrization scheme can be perturbed using an independent stochastic pattern. This acknowledges that the forecast errors arising from different parametrizations are not perfectly correlated. Two variations of this ‘independent SPPT’ (iSPPT) approach are tested in the Integrated Forecasting System (IFS). The first perturbs all parametrized tendencies independently, while the second groups tendencies before perturbation. The iSPPT schemes lead to statistically significant improvements in forecast reliability in the Tropics in medium‐range weather forecasts. This improvement can be attributed to a large, beneficial increase in ensemble spread in regions with significant convective activity. The iSPPT schemes also lead to improved forecast skill in the extratropics for a set of cases in which the synoptic initial conditions were more likely to result in European ‘forecast busts’. Longer 13 month simulations are also considered to indicate the effect of iSPPT on the mean climate of the IFS.
Analysis of non-stationary (seasonal/cyclical) long memory processes

Long memory, also called long range dependence (LRD), is commonly detected in the analysis of real-life time series data in many areas; for example, in finance, in econometrics, in hydrology, etc. Therefore the study of long-memory time series is of great value. The introduction of ARFIMA (fractionally autoregressive integrated moving average) process established a relationship between the fractional integration and long memory, and this model has found its power in long-term forecasting, hence it has become one of the most popular long-memory models in the statistical literature. Specifically, an ARFIMA(p,d,q) process X, is defined as follows: cD(B)(I - B)d X, = 8(B)c, , where cD(z)=l-~lz-•••-~pzP and 8(z)=1-B1z- . •-Bqzq are polynomials of order $p$ and $q$, respectively, with roots outside the unit circle; and c, is Gaussian white noise with a constant variance a2 . When c" X, is stationary and invertible. However, the a priori assumption on stationarity of real-life data is not reasonable. Therefore many statisticians have made their efforts to propose estimators applicable to the non-stationary case. Then questions arise that which estimator should be chosen for applications; and what we should pay attention to when using these estimators. Therefore we make a comprehensive finite sample comparison of semi-parametric Fourier and wavelet estimators under the non-stationary ARFIMA setting. ln light of this comparison study, we have that (i) without proper scale trimming the wavelet estimators are heavily biased and the y generally have an inferior performance to the Fourier ones; (ii) ail the estimators under investigation are robust to the presence of a linear time trend in levels of XI and the GARCH effects in variance of XI; (iii) the consistency of the estimators still holds in the presence of regime switches in levels of XI , however, it tangibly contaminates the estimation results. Moreover, the log-regression wavelet estimator works badly in this situation with small and medium sample sizes; and (iv) fully-extended local polynomial Whittle Fourier (fextLPWF) estimator is preferred for a practical utilization, and the fextLPWF estimator requires a wider bandwidth than the other Fourier estimators.