Miracle-dz/UniFAR-FTUs huggingface dataset:
Unification of BL Lac objects and FR I and FR II(G) radio galaxies, and Doppler factor estimation for BL Lac objects

In this work, we collected a sample of BL Lacs and FR I and FR II(G) radio galaxies with available core and extended emissions from published works to discuss the unified schemes and estimate the Doppler factor for BL Lacs. A Wilcoxon rank-sum test and a Kolmogorov–Smirnov test both suggest that the probabilities of the distribution of the extended luminosity of BL Lacs and that of FR I and FR II(G) radio galaxies being from the same parent distribution are pWRS = 0.779 and pK-S = 0.326, suggesting they are unified. Based on this unified scheme, we propose to estimate the Doppler factors for BL Lacs. Comparing the Doppler factor estimated by the fitting/regression method with those for the common sources in the literature, we found a good linear correlation for common sources.
Polycapillary x-ray optics for macromolecular crystallography

Polycapillary x-ray optics have found potential application in many different fields, including antiscatter and magnification in mammography, radiography, x-ray fluorescence, x-ray lithography, and x-ray diffraction techniques. In x-ray diffraction, an optic is used to collect divergent x-rays from a point source and redirect them into a quasi-parallel, or slightly focused beam. Monolithic polycapillary optics have been developed recently for macromolecular crystallography and have already shown considerable gains in diffracted beam intensity over pinhole collimation. Development is being pursued through a series of simulations and prototype optics. Many improvements have been made over the stage I prototype reported previously, which include better control over the manufacturing process, reducing the diameter of the output beam, and addition of a slight focusing at the output of the optic to further increase x-ray flux at the sample. We report the characteristics and performance of the stage I and stage II optics.
COVID 19 Fear Impact among Russian “Helping Profession” Students

Background: Little is known about the COVID-19 impact on Russian medical, psychology and social work students’ psycho-emotional well-being, substance use and resilience. Methods: More than 2000 helping profession students, 75.4% female, participated in an online survey about COVID-19 impact at a peak time of infection (October/November 2020). The Fear of COVID-19 Scale (FCV-19S) and Brief Resilience Scale (BRS) were used for study purposes. Furthermore, the influence of COVID-19 on student psycho-emotional well-being and substance use (i.e., tobacco and alcohol) was examined. Results: Medical, female and religious students reported higher fear values. Social work students reported more current substance use, including binge drinking (five or more drinks on one particular occasion). Students who reported COVID-19 associated with their psycho-emotional well-being had higher fear values. Regarding resilience, no association was found based on the student study area. However, male and non-religious students reported more resilience. Students who reported substance use and psycho-emotional problems had lower resilience values. Conclusion: COVID-19 fear and substance use differs among Russian students based on background characteristics. including gender, religiosity and study area. The FCV-19S and the BRS were found to be reliable instruments for research of COVID-19-related psycho-emotional problems, substance use and resilience. Study findings have implications for “front line” helping profession students in terms of education, training and intervention, in support of promoting their ability to address difficult conditions resulting from the pandemic and other disaster conditions in the future.
Predicting Effects of ADHD Symptoms and Mindfulness on Smartphone Overuse in Athletes: A Basic Psychological Needs Perspective

Informed by basic psychological need theory, this study was undertaken to examine the relationship between self-reported symptoms of attention deficit hyperactivity disorder (ADHD), mindfulness, basic psychological need satisfaction/frustration, and smartphone overuse among athletes. Athletes (n = 360, Mage = 20.27, male = 72.5%) completed a survey that measured the outcomes of interest. Path analysis indicated that greater ADHD symptoms were both directly related to higher smartphone overuse scores and indirectly related to greater smartphone overuse scores via need frustration. Higher mindfulness scores were associated with lower levels of need frustration and greater levels of need satisfaction. Mindfulness moderated the positive association between ADHD symptoms and need frustration. Specifically, the positive association between ADHD symptoms and need frustration was attenuated in the presence of higher levels of mindfulness among participants with a lower risk of ADHD. Surprisingly, the same association was heightened among participants with a higher risk of ADHD. These findings highlight the significant role of need frustration in explaining the underlying process from ADHD symptoms to smartphone overuse.
GPM Annual and Daily Precipitation Data for Real-Time Short-Term Nowcasting: A Pilot Study for a Way Forward in Data Assimilation

This study explores the quality of data produced by Global Precipitation Measurement (GPM) and the potential of GPM for real-time short-term nowcasting using MATLAB and the Short-Term Ensemble Prediction System (STEPS). Precipitation data obtained by rain gauges during the period 2015 to 2017 were used in this comparative analysis. The results show that the quality of GPM precipitation has different degrees efficacies at the national scale, which were revealed at the performance analysis stage of the study. After data quality checking, five representative precipitation events were selected for nowcasting evaluation. The GPM estimated precipitation compared to a 30 min forecast using STEPS precipitation nowcast results, showing that the GPM precipitation data performed well in nowcasting between 0 to 120 min. However, the accuracy and quality of nowcasting precipitation significantly reduced with increased lead time. A major finding from the study is that the quality of precipitation data can be improved through blending processes such as kriging with external drift and the double-kernel smoothing method, which enhances the quality of nowcast over longer lead times.
Effect of net shading technology on the yield quality and quantity of chilli pepper under greenhouse cultivation

This study was undertaken to identify the effect of net shading technology on the total capsaicinoids, vitamin C and relative chlorophyll content expressed as SPAD (Soil Plant Analysis Development) values and total marketable fruit yield of ‘Star Flame’ chilli pepper (Capsicum annuum) for two harvesting times cultivated under modified atmosphere. ‘Star Flame’ pepper was grown under three (3) different net shading colours (white, red and green). Samples without net shading were used as control. Samples were subjected to chromatographic analyses using HPLC for the determination of total capsaicinoids and vitamin C. Interaction in shading technology and harvest times (p=0.010) had significant effect on total capsaicinoids as a result of green and white shading technologies showing higher differences when compared to control samples. Vitamin C content was observed to have increased in white and red shadings (p=0.001) after the first harvest and gradually decreased after the second harvesting time (p=0.002). Relative leaf chlorophyll content was significantly higher in white shading in the first and second harvest. Samples used as control had significantly higher marketable values when compared to white and green shadings with red recording low marketability of ‘Star Flame’ chilli peppers.
Cluster-based probabilistic structure dynamical model of wind turbine wake

For complex flow systems like the one of the wind turbine wakes, which include a range of interacting turbulent scales, there is the potential to reduce the high dimensionality of the problem to low-rank approximations. Unsupervised cluster analysis based on the proper orthogonal decomposition is used here to identify the coherent structure and transition dynamics of wind turbine wake. Through the clustering approach, the nonlinear dynamics of the turbine wake is presented in a linear framework. The features of the fluctuating velocity are grouped based on similarity and presented as the centroids of the defining clusters. Determined from probability distribution of the transition, the dynamical system identifies the features of the wakes and the inherent dynamics of the flow.
Robust predictive iterative learning control for linear time‐varying systems

A novel control technique is proposed by combining iterative learning control (ILC) with model predictive control (MPC) for a trajectory tracking problem of linear time‐varying systems (LTVSs) in this paper. By introducing prediction mechanism along both of the iteration and time directions instead of only one direction, the control law is successively updated along two directions by learning from the predictive and compensatory information. The new control law can improve convergence speed and effectively suppress the uncertainties in initial states, external disturbances, and model mismatches. The convergence conditions are rigorously derived and analyzed as well. An example is given to illustrate the effectiveness of the obtained results.
Order release, dispatching and resource assignment in multiple resource-constrained job shops: an assessment by simulation

In manufacturing shops in practice, machine capacity is often constrained by more than one type of resource. Yet research mainly focusses on the effects of only one type of resource that constrains machine capacity, e.g. labour, tooling or auxiliary constraints. In response, we use simulation to assess the impact of order release, dispatching and resource assignment rules in make-to-order job shops with multiple resource constraints. The capacity wasted while a machine stands idle waiting for other resources increases with the number of constraints, and all three production planning and control functions have little impact on this waiting time. Effective production planning and control can however improve operational performance in terms of time and tardiness-related measures. In general, combining order release control with a dispatching rule that prioritises jobs for which all resources are available at dispatching and a longest queue resource assignment rule leads to the best performance. Most importantly, and rather counterintuitively, prioritising orders with the fewest missing resources worsens the performance of both the dispatching and resource assignment rule since it reduces resource utilisation during periods of high load. Results from dual resource-constrained shops are consequently not directly transferable to more complex resource-constrained shops.
Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues

Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive conditions, and non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the contemporary search and design of novel anticonvulsants. In the present paper, evaluation of the anticonvulsant activity of the potential NSAID dual COX-2/5-LOX inhibitor darbufelone methanesulfonate using an scPTZ model in mice in dose 100 mg/kg is reported. Darbufelone possesses anticonvulsant properties in the scPTZ model and presents interest for in-depth studies as a possible anticonvulsant multi-target agent with anti-inflammatory activity. The series of 4-thiazolidinone derivatives have been synthesized following the analogue-based drug design and hybrid-pharmacophore approach using a darbufelone matrix. The synthesized derivatives showed a significant protection level for animals in the scPTZ model and are promising compounds for the design of potential anticonvulsants with satisfactory drug-like parameters.
Circadian Rhythms and Homeostatic Mechanisms for Sleep Regulation

This chapter examines circadian rhythms and homeostatic mechanisms for sleep regulation. It reviews the current evidence describing the two-process model of sleep regulation and how to assess disruption to either of these sleep drives. This chapter also reviews the role of the photic and non-photic resetting of the circadian rhythm and describes how some aspects of modern society can cause sleep and circadian disruption. Further, this chapter describes how misalignment between the circadian rhythm and sleep homeostasis, such as occurs during jet lag and shift-work, can lead to sleep disruption. The short- and long-term consequences of circadian misalignment are also reviewed.
Pharmacovigilance pregnancy data in a large population of patients with chronic inflammatory disease exposed to certolizumab pegol

Introduction: Chronic inflammatory diseases (CIDs), including rheumatic diseases and other inflammatory conditions, often affect women of reproductive age. Tumor necrosis factor inhibitors (TNFi) are widely used to treat CID, but there is limited information on outcomes of TNFi-exposed pregnancies. We evaluated pregnancy outcomes from 1392 prospectively reported pregnancies exposed to certolizumab pegol (CZP), a PEGylated, Fc-free TNFi with no to minimal placental transfer. Methods: CZP-exposed pregnancies in patients with CID from the UCB Pharmacovigilance global safety database were reviewed from the start of CZP clinical development (July 2001) to 1 November 2020. To limit bias, the analysis focused on prospectively reported cases with known pregnancy outcomes. Results: In total, 1392 prospective pregnancies with maternal CZP exposure and known pregnancy outcomes (n = 1425) were reported; 1021 had at least first-trimester CZP exposure. Live birth was reported in 1259/1425 (88.4%) of all prospective outcomes. There were 150/1425 (10.5%) pregnancy losses before 20 weeks (miscarriage/induced abortion), 11/1425 (0.8%) stillbirths, and 5/1392 (0.4%) ectopic pregnancies. Congenital malformations were present in 30/1259 (2.4%) live-born infants, of which 26 (2.1%) were considered major according to the Metropolitan Atlanta Congenital Defects Program criteria. There was no pattern of congenital malformations. Discussion and conclusion: No signal for adverse pregnancy outcomes or congenital malformations was observed in CZP-exposed pregnancies. Although the limitations of data collected through this methodology (including underreporting, missing information, and absence of a comparator group) should be considered, these data provide reassurance for women with CID who require CZP treatment during pregnancy, and their treating physicians.
Analisis Kemampuan Generalisasi Siswa SMP Negeri 08 Karawang Pada Materi Segitiga

Pada penelitian ini terdapat tujuan yaitu untuk menganalisis kemampuan generalisasi yang dimiliki siswa dalam menyelesaikan soal matematika pada materi segitiga. Metode penelitian ini adalah penelitian kualitatif deskriptif. Dengan subjek penelitian sebanyak 35 siswa kelas VIII di SMP Negeri 08 Karawang. Instrumen yang digunakan adalah tes tertulis yang terdiri dari tiga soal dan wawancara. Selanjutnya akan dianalisis jawaban siswa perindikator pada kemampuan generalisasi. Adapun hasil penelitian ini menunjukkan bahwa rata-rata kemampuan generalisasi yang dimiliki siswa kelas VIII di SMP Negeri 08 Karawang tergolong sangat rendah. Hal ini dibuktikan bahwa sebesar 17.14% siswa berkategori tinggi memiliki skor nilai 15 dan 54.29% siswa berkategori rendah dengan perolehan skor 0.
A novel solid-liquid equilibrium model for describing the adsorption of associating asphaltene molecules onto solid surfaces based on the "chemical theory"

Asphaltenes exhibit an amphiphlic behavior and tend to form colloidal i-mers, because of their chemical structure. The formation of colloidal aggregates can generate formation damage for the precipitation and/or deposition of asphaltenes, because of the degree of self-association, altering the wettability of rock surface and significantly affect crude oil viscosity and specific gravity. This study aims at introducing a novel model for describing, at the macroscopic level, the adsorption equilibria of self-associating molecules such as asphaltenes in solution onto solid surfaces based on the “chemical theory”. The model describes the adsorption isotherms temperature-dependent using three parameters, namely, maximum amount adsorbed, constant of i-mer reactions, and Henry’s law constant. Furthermore, a temperature-independent model of five parameters, based on the modifications of the constants of reaction and Henry’s law using an Arrhenius-type equation was proposed for estimating the thermodynamics paramet.
Developmental Trajectories for Novice Elementary Teachers: Teaching Efficacy and Mathematics Knowledge

This study investigated developmental trajectories of novice elementary teachers’ efficacy beliefs (i.e., personal teaching efficacy and outcome expectancy) and their mathematical knowledge for teaching (MKT). Overall, study findings indicated growth in participants’ personal efficacy beliefs and in various assessments for dimensions of MKT. Additional relationships between participants’ MKT trajectories and their mathematics efficacy beliefs trajectories were found. Findings from our study can help teacher educators, researchers, and school leaders in better understanding how novice teachers develop their MKT and their teaching efficacy beliefs during the teacher education program and in their first years of teaching.
Mechanisms of density dependence in juvenile salmonids: prey depletion, interference competition, or energy expenditure?

Density dependence is a strong regulator of animal populations, operating primarily through intraspeci ﬁ c competition for a limiting resource. Because food is generally limited in natural environments, it is typically assumed that increasing animal density leads to reduced individual ﬁ tness through food depletion or monopolization. However, recent work demonstrates that density dependence can occur without apparent food depletion, or with virtually unlimited resources, suggesting that other mechanisms must also be important. Alternatively, density-dependent regulation could be achieved through increasing energy costs rather than decreasing food abundance. The relative importance of these two processes (food depletion and energy costs) and their underlying mechanisms remains unclear. Here, we manipulated the density of juvenile stream-dwelling brook trout ( Salvelinus fontinalis ) in three neighboring populations over two consecutive summers to relate food availability and consumption to density-dependent growth, survival, and their trade-off. Despite strong patterns of density dependence and evidence of food limitation, increasing ﬁ sh density did not lead to detectable prey depletion in the environment. Instead, behavioral observations suggested that increasing densities resulted in higher energetic costs, primarily via increasing interference competition and the use of less suitable foraging microhabitats. These results highlight that animal populations may be regulated by density dependence without necessarily impacting prey communities.
Controls on the Spatial Distribution of Near‐Surface Pyrogenic Carbon on Hillslopes 1 Year Following Wildfire

Wildfire alters hydrologic and geomorphic systems, promoting increases in runoff and erosion relative to unburned areas. As a result, pyrogenic carbon (PyC) produced by wildfires can experience substantial lateral redistribution from overland flow. Since landscape position helps to determine the fate of PyC, it is critical to understand the geomorphic factors that govern its lateral redistribution as well as the sensitivity of those factors to soil burn severity, which controls the magnitude of many wildfire‐induced hydrologic and geomorphic changes. In this study, we quantified the spatial distribution of near‐surface (0–5 cm) PyC on three hillslopes roughly 1 year after the 2018 Buzzard Fire in the Gila National Forest, New Mexico, USA. We then use hydrologic monitoring data, terrain analysis, and rainfall‐runoff modeling to explain the observed spatial distribution of PyC. Near‐surface PyC concentrations decreased from averages of roughly 12–8 g/kg as slope and unit stream power increased by factors of ∼2 and 4, respectively, on a hillslope burned at low severity. This suggests that susceptibility to runoff‐driven erosion was a dominant control on the redistribution of PyC. In contrast, the spatial distribution of PyC in areas burned at moderate to high severity was independent of slope and unit stream power. We attribute this pattern to intense runoff and lack of canopy cover, which promoted erosion of PyC regardless of slope and landscape position. Results demonstrate that how wildfire‐induced hydrogeomorphic changes can modulate the importance of terrain attributes in controlling the spatial distribution of PyC in upland landscapes.
Factor Associated with Underweight among People with Tuberculosis

1 Department of Epidemiology, Faculty of Public Health, Universitas Airlangga, wildana.widad. fitriyana2016@fkm.unair. ac.id 2 Department of Epidemiology, Faculty of Public Health, Universitas Airlangga, dewi.puji. ayuningum2016@fkm.unair. ac.id Correspondence Author: Wildana Widad Fitriyana, wildana.widad. fitriyana-2016@fkm.unair. ac.id, Departement of Epidemiology, Faculty of Public Health, Universitas Airlangga, Dr. Ir. H. Soekarno Street, Mulyorejo, Surabaya City, East Java, 60115, Indonesia
Acalabrutinib ± obinutuzumab versus obinutuzumab + chlorambucil in treatment-naïve chronic lymphocytic leukemia: Elevate-TN four-year follow up.

7509Background: Early results from ELEVATE-TN (NCT02475681) at a median follow-up of 28.3 mo demonstrated superior efficacy of acalabrutinib (A) ± obinutuzumab (O) compared with O + chlorambucil (C.
Roman Wall Paintings: Characterisation of Plaster Coats Made of Clay Mud

This paper reports on the mineralogical characterisation of samples of wall paintings from various Roman sites in Lombardy (Italy), revealing recurrent types of stratigraphy. One of the stratigraphic samples analysed was found to be a particular kind of plaster: a three-coat work featuring two coats made of clay mud, found in the site of Santa Maria alla Porta (area of the Imperial Palace of Milan—first century CE). The fragments were analysed using optical microscopy on thin sections, X-ray diffraction, scanning electron microscopy with an energy-dispersive spectrometer and infrared spectroscopy, also in non-invasive external reflection mode (7500–375 cm−1). The most interesting feature found was the finish coat made of clay mud (illite, chlorite, kaolinite and fine quartz) with a few coarse clasts and linear cavities. This clay coat was the first example ever detected in Roman Lombardy and was used in combination with a thin painted coat made of clay mud with coarse clasts together with a blue pigment (Egyptian blue) and a render coat made of lime associated with lithic clasts (sand). Our findings brought to light a particular construction technique, since in the historical sources clay is only recommended for daubing on reeds and as a render coat.