Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer’s Disease

KLOTHO-VS heterozygosity (KL-VShet+) promotes longevity and protects against cognitive decline in aging. To determine whether KL-VShet+ mitigates Alzheimer’s disease (AD) progression, we used longitudinal linear-mixed models to compare the rate of change in multiple cognitive measures in AD patients stratified by APOE ε4 carrier status. We aggregated data on 665 participants (208 KL-VShet−/ε4−, 307 KL-VShet−/ε4+, 66 KL-VShet+/ε4−, and 84 KL-VShet+/ε4+) from two prospective cohorts, the National Alzheimer’s Coordinating Center and the Alzheimer’s Disease Neuroimaging Initiative. All participants were initially diagnosed with mild cognitive impairment, later developed AD dementia during the study, and had at least three subsequent visits. KL-VShet+ conferred slower cognitive decline in ε4 non-carriers (+0.287 MMSE points/year, p = 0.001; −0.104 CDR-SB points/year, p = 0.026; −0.042 ADCOMS points/year, p < 0.001) but not in ε4 carriers who generally had faster rates of decline than non-carriers. Stratified analyses showed that the protective effect of KL-VShet+ was particularly prominent in male participants, those who were older than the median baseline age of 76 years, or those who had an education level of at least 16 years. For the first time, our study provides evidence that KL-VShet+ status has a protective effect on AD progression and interacts with the ε4 allele.
Invariant Subspaces of Continuous Functions

Since Beurling (1 ), the study of closed invariant subspaces of Hp (X) and Lp (X) on the unit circle X = {z:|z| = 1} has been done extensively and culminated into a very fine theory of generalized analytic functions ; cf. Hoffman (4), Srinivasan (7). Here we say that a space E of complex-valued functions on X is invariant if zE ⊆ E. Little is known, however, about the structure of closed invariant subspaces E of the space C(X) of continouus functions on X.
Novel radar dwell scheduling algorithm based on pulse interleaving

The problem of scheduling radar dwells in multifunction phased array radar systems is addressed. A novel dwell scheduling algorithm is proposed. The whole scheduling process is based on an online pulse interleaving technique. It takes the system timing and energy constraints into account. In order to adapt the dynamic task load, the algorithm considers both the priorities and deadlines of tasks. The simulation results demonstrate that compared with the conventional adaptive dwell scheduling algorithm, the proposed one can improve the task drop rate and system resource utility effectively.
Aerodynamics of a Small-Scale Vertical-Axis Wind Turbine with Dynamic Blade Pitching

This paper describes the systematic experimental and computational studies performed to investigate the performance of a small-scale vertical-axis wind turbine using dynamic blade pitching. A vertical-axis wind turbine prototype with a simplified blade pitch mechanism was designed, built, and tested in the wind tunnel to understand the role of pitch kinematics in turbine aerodynamic efficiency. A computational fluid dynamics model was developed, and the model predictions correlated well with test data. Both experimental and computational fluid dynamics studies showed that the turbine efficiency is a strong function of blade pitching amplitude, with the highest efficiency occurring around ±20 to ±25 deg amplitude. The optimum tip-speed ratio depends on the blade pitch kinematics, and it decreases with increasing pitch amplitude for the symmetric blade pitching case. A computational fluid dynamics analysis showed that the blade extracted all the power in the frontal half of the circular trajectory; however.
Monte Carlo confidence intervals

Des intervalles de confiance non parametriques obtenus par la methode de Monte-Carlo sont utiles quand les intervalles obtenus par les methodes analytiques sont indisponibles ou ne correspondent pas au niveau nominal. On fournit des formules permettant de generer un intervalle de niveau donne et de quantifier la variation due a la methode de Monte-Carlo
Rotational shear effects on edge harmonic oscillations in DIII-D quiescent H-mode discharges

In the quiescent H-mode (QH-mode) regime, edge harmonic oscillations (EHOs) play an important role in avoiding transient edge localized mode (ELM) power fluxes by providing benign and continuous edge particle transport. A detailed theoretical, experimental and modeling comparison has been made of low-n (n ⩽ 5) EHO in DIII-D QH-mode plasmas. The calculated linear eigenmode structure from the extended magentoohydrodynamics (MHD) code M3D-C1 matches closely the coherent EHO properties from external magnetics data and internal measurements using the ECE, BES, ECE-Imaging and microwave imaging reflectometer (MIR) diagnostics, as well as the kink/peeling mode properties found by the ideal MHD code ELITE. Numerical investigations indicate that the low-n EHO-like solutions from M3D-C1 are destabilized by rotation and/or rotational shear while high-n modes are stabilized. This effect is independent of the rotation direction, suggesting that EHOs can be destabilized in principle with rotation in either direction. The modeling results are consistent with observations of EHO, support the proposed theory of the EHO as a low-n kink/peeling mode destabilized by edge E × B rotational shear, and improve our understanding and confidence in creating and sustaining QH-mode in present and future devices.
Psychological empowerment and organizational citizenship behavior in the information communications and technology (ICT) sector: A moderated- mediation model

Abstract This study aimed to examine the influence of psychological empowerment on job crafting. Moreover, it analyzed the relationship between job crafting and organizational citizenship behavior. In addition, conscientiousness was considered as a moderator between psychological empowerment and job crafting. Whereas the mediation effect of job crafting was examined among psychological empowerment and organizational citizenship behavior. The data were gathered from the ICTs of Jordan and AMOS was used for analysis. The results highlighted that psychological empowerment can influence job crafting, which can lead to organizational citizenship behavior. Therefore, job crafting can significantly mediate the relationship between psychological empowerment and organizational citizenship behavior. In addition, the findings revealed that conscientiousness being an important personality trait can moderate the relationship between psychological empowerment and job crafting. This research can be considered as a guideline for researchers and practitioners focusing on job crafting and organizational citizenship behavior. The focus of this research is merely on the employees of ICTs and it has considered only one personality trait i.e. conscientiousness. Therefore, future studies can emphasize any other sector and include other personality traits as moderators.
Augmented Reality Support for Anterior Decompression and Fusion Using Floating Method for Cervical Ossification of the Posterior Longitudinal Ligament

Anterior decompression and fusion (ADF) using the floating method for cervical ossification of the posterior longitudinal ligament (OPLL) is an ideal surgical technique, but it has a specific risk of insufficient decompression caused by the impingement of residual ossification. Augmented reality (AR) support is a novel technology that enables the superimposition of images onto the view of a surgical field. AR technology was applied to ADF for cervical OPLL to facilitate intraoperative anatomical orientation and OPLL identification. In total, 14 patients with cervical OPLL underwent ADF with microscopic AR support. The outline of the OPLL and the bilateral vertebral arteries was marked after intraoperative CT, and the reconstructed 3D image data were transferred and linked to the microscope. The AR microscopic view enabled us to visualize the ossification outline, which could not be seen directly in the surgical field, and allowed sufficient decompression of the ossification. Neurological disturbances were improved in all patients. No cases of serious complications, such as major intraoperative bleeding or reoperation due to the postoperative impingement of the floating OPLL, were registered. To our knowledge, this is the first report of the introduction of microscopic AR into ADF using the floating method for cervical OPLL with favorable clinical results.
Modeling Preferences Using Roll Call Votes in Parliamentary Systems

Models of ideal point estimation usually build on the assumption of spatial preferences. This ignores legislators' non-policy incentives and is thus likely to produce implausible results for many legislatures. We study this problem in parliamentary systems and develop a model of roll call voting that considers both the policy and the non-policy, tactical incentives of legislators. We go on to show how the relative weight of these policy and tactical incentives is influenced by the identity of the mover and characteristics of the motion. Analyses of two data sets of 2174 roll call votes in German state legislatures and 3295 roll call votes in the British House of Commons result in three main findings. First, we show that tactical incentives may be more important than policy incentives, and second, that the importance of tactical incentives varies with the importance of motions. Third, there are interesting twists: backbench private members' bills may reverse tactical incentives whereas proposals from anti-system parties are virtually always rejected by moderate parties, rendering these votes uninformative. Our findings have implications for ideal point estimation in parliamentary systems, as well as for research on separation of power systems.
Perceptions of leadership, self-confidence and leadership programs among teenage girls in Israel

Abstract This article examines the way post-primary school contributes to the extent female teenagers perceive themselves as leaders. Based on 14 in-depth interviews among teenage girls who are attending middle and high schools in the public education system in Israel, it focuses on their personal social experiences and perceptions regarding their school as a leadership development establishment. The girls describe leaders, and themselves, as people who are tolerant of other opinions. They stress that self-confidence is a key element in becoming a leader. Leadership programs conducted in schools are viewed as empowering yet not practical. They experience an absence of role modeling and mentoring at school and express an indecisive approach from their school as a leadership development establishment.
Prognostic Role of Circulating Tumor Cell Trajectories in Metastatic Colorectal Cancer

Background: A large amount of evidence from clinical studies has demonstrated that circulating tumor cells are strong predictors of outcomes in many cancers. However, the clinical significance of CTC enumeration in metastatic colorectal cancer is still questioned. The aim of this study was to evaluate the clinical value of CTC dynamics in mCRC patients receiving first-line treatments. Materials and methods: Serial CTC data from 218 patients were used to identify CTC trajectory patterns during the course of treatment. CTCs were evaluated at baseline, at a first-time point check and at the radiological progression of the disease. CTC dynamics were correlated with clinical endpoints. Results: Using a cut-off of ≥1 CTC/7.5 mL, four prognostic trajectories were outlined. The best prognosis was obtained for patients with no evidence of CTCs at any timepoints, with a significant difference compared to all other groups. Lower PFS and OS were recognized in group 4 (CTCs always positive) at 7 and 16 months, respectively. Conclusions: We confirmed the clinical value of CTC positivity, even with only one cell detected. CTC trajectories are better prognostic indicators than CTC enumeration at baseline. The reported prognostic groups might help to improve risk stratification, providing potential biomarkers to monitor first-line treatments.
A Latent Class Analysis of Intergenerational Relationships Among the Elderly Migrants in Nanjing, China

Objective This study aimed to identify (1) different types of intergenerational relationships among the elderly migrants, (2) factors influencing each type of relationship, and (3) the types significantly associated with psychological well-being of the elderly migrants. Methods Data were collected from 654 elderly migrants in Nanjing, China. Incorporating ten solidarity conflict indicators, the latent class analysis (LCA) was performed to classify intergenerational relationships. Logistic regression were used to analyze influencing factors, and ordinary least squares (OLS) regression was used to analyze the relationship of each type of intergenerational relationship with depression and life satisfaction. Results Three types of intergenerational relationships were classified: tight-knit (65%), conflicting (25%), distant intimate (10%). Gender, marital status, education level, annual income, subjective health, number of children and parentage were influencing factors for the three types. The tight-knit type predicted a healthy mental status. Discussion Three intergenerational relationships exist between elderly migrants and their children in Nanjing, China. A closer relationship predicts a better mental health in the elderly migrants.
PB Phase-Based Broadband Terahertz Transmissive Encoded Metasurface

In this paper, a PIN diode-controlled 1bit reconfigurable transmissive coded metasurface in W-band is proposed, which is integrated with two symmetrically placed packaged PIN diodes to achieve 1bit phase regulation capability by controlling the current reversal of both diodes. Simulation results show that this transmissive coded metasurface can achieve a stable 180° phase shift in the W-band with a transmission coefficient greater than -4 dB between 91.25 GHz and 100.79 GHz, achieving amplitude phase modulation with a relative bandwidth greater than 10% and a two-dimensional beam sweep range of ±45°.
Allergen-Free Food Dataset and Comparative Analysis of Recommendation Algorithms

Food sensitivities brought about by allergens, for example, gluten, shellfish, nuts, soy and dairy, are developing at an outstanding rate affecting at least 3% of the world at any given time. In developed nations, allergen-free food is widely available because of better clinical and patient mindfulness, significant access to substitutes and financial stability to keep a sans allergen diet. This isn't the situation in the rest of the world, especially in countries like India where unavailability is a huge issue. This paper proposes a dataset consisting of allergen-free food and a comparative analysis of algorithms like Normalized Levenshtein, Damerau Levenshtein, Cosine Similarity, Jaro Winkler and Metric LCS in the context of recommending hypoallergenic variants of products from this dataset to customers.
Sur les feuilletages induits par l'action de groupes de Lie nilpotents

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Item Parceling Strategies in Structural Equation Modeling

Item parceling is a technique using in structural equation modeling(SEM) . Parceling can improve the quality of indicators and model fit.Bias that due to parceling was often neglectable and can be corrected.Parceling greatly enhances model parsimony,but it greatly reduces falsifiability of the tested model.It could be summarized that the prerequisites of parceling are unidimension and homogeneity,and the applicability of parceling is the analysis of structural models,rather than measurement models.Parcel-building algorithms and the number of parcels were discussed and recommended.A procedure for item parceling was proposed when the scale was unidimensional.If the scale was multidimensional,internal-consistency approach was recommended such that the items of the same dimension are parceled to one or three indicators for structural equation modeling.
Intelligent-Reflecting-Surface-Enhanced Cell-Free Symbiotic Radio Systems

This article considers a novel intelligent reflecting surface (IRS)-assisted cell-free symbiotic radio (SR) system, where an IRS is employed to facilitate the transmission from all the base stations (BSs) to the primary receivers (PRs), i.e., the primary transmission, and simultaneously, to send messages to the Internet of Things (IoT) devices, i.e., the secondary transmission. We aim to minimize the bit error rate (BER) of the IRS symbols by jointly optimizing the transmit beamformers at all the BSs and the IRS phase shifts. To solve this nonconvex problem, we propose a plenty-based algorithm by using the multidimensional complex quadratic transform (MCQT) and the consensus alternative direction method of multipliers (ADMMs) methods, and obtain a high-performance solution. Besides, the convergence of the proposed algorithm is analyzed. Simulation results demonstrate the effectiveness of the proposed algorithm and show that the proposed algorithm outperforms two baselines under different setups.
The development of upper‐tropospheric geopotential height anomaly in the Western Hemisphere during MJO convective initiations

This study uses geopotential height budget and composite analysis of reanalysis data to examine the driving dynamics and structural evolution of intraseasonal upper‐tropospheric circulation over the Western Hemisphere (WH) prior to and during the convective initiation of the Madden–Julian Oscillation (MJO) over the Indian basin. Previous studies by the authors showed that, during most of MJO convective initiation events over the Indian basin, upper‐tropospheric equatorial easterly wind anomaly initially develops in association with subtropical and midlatitude Rossby ridges over the east Pacific basin. As the easterly wind continues to amplify and propagate farther eastward, a negative upper‐tropospheric geopotential height anomaly develops over tropical South America and couples with the easterly wind anomaly, forming a structure consistent with theoretical Kelvin waves. This study shows that the development of the negative geopotential height anomaly over South America is driven by net tropospheric adiabatic cooling induced by updraughts. The convection associated with the updraughts is triggered by the intrusion of a midlatitude wave train from the Southern Hemisphere, suggesting that the interaction with midlatitude circulation is a part of the dynamics driving the formation of upper‐tropospheric Kelvin wave structure over the WH.
Dynamic Analysis and Preliminary Evaluation of a Spring-Loaded Upper Limb Exoskeleton for Resistance Training with Overload Prevention

Resistance training has been shown to be effective for developing musculoskeletal strength and is recommended by many major health organizations, such as the American College of Sports Medicine and the American Heart Association. This form of training is available for most populations, including adolescents, healthy adults, the elderly, and the clinical population. Resistance training equipment design relies heavily on the analysis of human movement. Dynamic models of human movement help researchers identify key forces, movements, and movement patterns that should be measured. An at-home resistance training upper limb exoskeleton has been designed with a three-degree-of-freedom shoulder joint and a one-degree-of-freedom elbow joint to allow movement of the upper limb at single and multiple joints in different planes. The exoskeleton can continuously increase the resistance as the spring length changes to train more muscle groups and to reduce the potential risk of muscle injury to the upper limb by free weights and training equipment. The objectives of this research were to develop a dynamic model of the spring-loaded upper limb exoskeleton and to evaluate this model by adopting an appropriate motion analysis system to verify our hypotheses and to determine the optimal configuration of a springloaded upper limb exoskeleton for further verification studies.
Reference‐based Screentone Transfer via Pattern Correspondence and Regularization

Adding screentone to initial line drawings is a crucial step for manga generation, but is a tedious and human‐laborious task. In this work, we propose a novel data‐driven method aiming to transfer the screentone pattern from a reference manga image. This not only ensures the quality, but also adds controllability to the generated manga results. The reference‐based screentone translation task imposes several unique challenges. Since manga image often contains multiple screentone patterns interweaved with line drawing, as an abstract art, this makes it even more difficult to extract disentangled style code from the reference. Also, finding correspondence for mapping between the reference and the input line drawing without any screentone is hard. As screentone contains many subtle details, how to guarantee the style consistency to the reference remains challenging. To suit our purpose and resolve the above difficulties, we propose a novel Reference‐based Screentone Transfer Network (RSTN). We encode the screentone style through a 1D stylegram. A patch correspondence loss is designed to build a similarity mapping function for guiding the translation. To mitigate the generated artefacts, a pattern regularization loss is introduced in the patch‐level. Through extensive experiments and a user study, we have demonstrated the effectiveness of our proposed model.
Effects of Culinary Procedures on Concentrations and Bioaccessibility of Cu, Zn, and As in Different Food Ingredients

Although cooked diets are the primary sources for humans to absorb trace elements, there is limited data available on the concentrations and bioaccessibility of trace elements in cooked food ingredients. This work aims to evaluate the effects of culinary procedures on the concentrations and bioaccessibility of trace elements in common food ingredients. Twelve food species from the local market were treated with four culinary procedures (boiling, steaming, baking, and frying), then the bioaccessibility of copper (Cu), zinc (Zn), and arsenic (As) were evaluated using the in vitro digestion method. The subcellular distribution of these elements was also determined using the sequential fractionation method. The results show that culinary procedures decreased the retention rate of As during cooking (100% for raw and 65–89% for cooked ingredients) and the bioaccessibility of Cu and Zn during digestion (nearly 75% for raw and 49–65% for cooked ingredients), resulting in a reduction of the total bioaccessible fraction (TBF) of Cu, Zn, and As in food ingredients. The TBF of Cu, Zn, and As in all tested food ingredients followed the order: raw (76–80%) > steaming and baking (50–62%) > boiling and frying (41–50%). The effects of culinary procedures were associated with the subcellular distribution of trace elements. As was dominantly distributed in heat-stable proteins (51–71%), which were more likely to be lost during cooking. In comparison, Cu and Zn were mainly bound to the insoluble fraction and heat-denatured proteins (60–89% and 61–94% for Cu and Zn, respectively), which become less digestible in cooked ingredients. In conclusion, these results suggest that culinary procedures reduce the absorption of Cu, Zn, and As in various food ingredients, which should be considered in the coming studies related to nutrition and risk assessment of trace elements.