Miracle-dz/UniFAR-FTUs huggingface dataset:
Vestibular function analysis of sudden sensorineural hearing loss with dizziness.

BACKGROUND A considerable number of patients with sudden sensorineural hearing loss (SSNHL) have been reported to have dizziness. OBJECTIVE To analyze vestibular functions and identify the clinical characteristics of SSNHL with dizzinessMETHODS:71 patients with SSNHL who complained of dizziness were investigated retrospectively. The patients underwent vestibular function tests consisting of video-nystagmography, video head impulse test and vestibular evoked myogenic potentials. RESULTS Among 35 patients with spontaneous nystagmus (SN), 21 showed ipsilesional posterior canal gain deficit, 11 showed a gain deficit in the posterior canal only and 9 showed both horizontal and posterior canal gain deficit in video head impulse test. In only one subject with bilateral horizontal canal gain deficit with contralesional SN, AICA infarction was observed.Among 36 patients without SN, 10 were diagnosed as benign paroxysmal positional vertigo and 5 had ipsilesional canal paresis in caloric test. Other 21 patients showed no abnormal signs in vestibular function tests. CONCLUSIONS In VFT analysis of SSNHL with dizziness, diverse patterns were identified. In the absence of SN, no definite vestibular organ involvement was the most frequent. But in the case with SN, posterior canal deficit was most common and cerebellar ischemic stroke was rare.
Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiology. Under pathological conditions in lungs with IPF, myofibroblasts serve a key role in fibrogenesis via the accumulation of an excessive amount of extracellular matrix. To develop effective therapeutic interventions against IPF, studies have recently focused on how to dedifferentiate established myofibroblasts. The present study revealed that JQ1, an inhibitor of bromodomain and extra-terminal proteins, markedly suppressed the expression levels of α-smooth muscle actin and ED-A-fibronectin in myofibroblasts prepared from the lung of a patient with end-stage IPF. Furthermore, these findings were supported by transcriptome analysis using RNA sequencing, in which differentially expressed genes (DEGs) downregulated by JQ1 treatment were significantly enriched in the fibrosis-related signaling pathway. On the other hand, the upregulated DEGs in response to JQ1 treatment were significantly enriched in glutathione metabolism, which may affect the cell status of fibroblast/myofibroblast. To the best of our knowledge, this was the first study to comprehensively analyze transcriptome profiles associated with dedifferentiation of IPF myofibroblasts.
Fear, xenophobia and collectivism as predictors of well-being during Coronavirus disease 2019: An empirical study from India

Background: The Coronavirus disease 2019 (COVID-19) has emerged as a global health threat. Biological disasters like this can generate immense prejudice, xenophobia, stigma and othering, all of which have adverse consequences on health and well-being. In a country as diverse and populous in India, such crisis can trigger communalism and mutual blame. Keeping this in context, this study explored the relationship between well-being and xenophobic attitudes towards Muslims, collectivism and fear of COVID-19 in India. Methods: The study was carried out on 600 non-Islamic Indians (231 males, 366 females and 3 others; mean age: 38.76 years), using convenience sampling. An online survey containing Fear of Coronavirus scale, Warwick–Edinburgh Mental Well-Being Scale and Collectivism Scale was used. Xenophobia was assessed using two scales: generalized prejudice towards Muslims and specific xenophobic tendencies towards Muslims during COVID-19. The data were analysed using correlational methods and multiple regression. Results: The findings showed that positively significant relationship exists between well-being and age as well as with collectivism, while an inversely significant relationship between well-being and fear of COVID-19 was found. The results of the multiple regression analysis shows that fear of COVID-19, age, collectivism and generalized xenophobia, in the order of their importance, together contributed to nearly 20% of variance in well-being. Conclusion: The findings are reflective of the importance of collectivism in enhancing well-being in these times of uncertainty. Xenophobia, one of the common offshoots of pandemics, can also harm the overall well-being. Implications are discussed in the light of India’s diverse socio-religious background and global context.
Fostering Stress Resilience Among Business Students: The Role of Stress Mindset and Self-Connection

Educators are becoming increasingly concerned about the high rates of burnout among their students. Although the solution may appear to be reducing the stress their students experience, simply reducing stress is a temporary solution and does not help students when they enter the workforce and encounter increased stressors. A better option may be to consider the ways in which students can increase stress resilience in ways that will help them long after they leave the classroom. With this idea in mind, we tested for relationships between two individual difference variables, stress mindset and self-connection, and burnout and life satisfaction among business students. The results showed there was a positive relationship between viewing stress as debilitating and prevalence of both personal and school-related burnout. Additionally, self-connection was negatively related to personal burnout and greater life satisfaction. Stress mindset and self-connection also interacted to predict both personal and school burnout. The results suggest that promoting adaptive views of stress and becoming more self-connected may lead to a better student experience.
Emotion perception in habitual players of action video games.

Action video game players (AVGPs) display superior performance in various aspects of cognition, especially in perception and top-down attention. The existing literature has examined these performance almost exclusively with stimuli and tasks devoid of any emotional content. Thus, whether the superior performance documented in the cognitive domain extend to the emotional domain remains unknown. We present 2 cross-sectional studies contrasting AVGPs and nonvideo game players (NVGPs) in their ability to perceive facial emotions. Under an enhanced perception account, AVGPs should outperform NVGPs when processing facial emotion. Yet, alternative accounts exist. For instance, under some social accounts, exposure to action video games, which often contain violence, may lower sensitivity for empathy-related expressions such as sadness, happiness, and pain while increasing sensitivity to aggression signals. Finally, under the view that AVGPs excel at learning new tasks (in contrast to the view that they are immediately better at all new tasks), the use of stimuli that participants are already experts at predicts little to no group differences. Study 1 uses drift-diffusion modeling and establishes that AVGPs are comparable to NVGPs in every decision-making stage mediating the discrimination of facial emotions, despite showing group difference in aggressive behavior. Study 2 uses the reverse inference technique to assess the mental representation of facial emotion expressions, and again documents no group differences. These results indicate that the perceptual benefits associated with action video game play do not extend to overlearned stimuli such as facial emotion, and rather indicate equivalent facial emotion skills in AVGPs and NVGPs. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Anxiety Mediates the Relationship between Psychotic-Like Experiences and Social Functioning in the General Population

Introduction: Within the psychosis continuum that includes schizophrenia (SZ) at the severe end and the general population at the mild end, anxiety may negatively impact social functioning more than psychosis or psychotic-like experiences (PLE). This claim is supported by previous reports that show anxiety mediates the relationship between psychosis and social functioning in SZ, suggesting anxiety is critical to social functioning in SZ. Yet no studies have examined a similar relationship in the general population, and this is important because people with PLE are at a significantly higher risk for developing full-blown psychosis. Methods: Similar to those with SZ, we predicted heightened anxiety would mediate the relationship between PLE, as measured by The Oxford-Liverpool Inventory of Feelings and Experiences, and social functioning, as measured by Social Adjustment Scale – Self-Report, in the general population. Results: Indeed, the current study showed that the relationship between PLE and social functioning was mediated by anxiety (z = 7.81, p < 0.001) within an unselected crowdsourcing sample representative of the general population (Amazon M-Turk; n = 197, mean age 32.38 years). Conclusion: Taken together with previous reports, the current findings suggest that anxiety is a functionally relevant dimension across the psychosis continuum and improving anxiety may improve social functioning across this continuum.
Estimation of incubation period and generation time based on observed length‐biased epidemic cohort with censoring for COVID‐19 outbreak in China

The incubation period and generation time are key characteristics in the analysis of infectious diseases. The commonly used contact‐tracing–based estimation of incubation distribution is highly influenced by the individuals' judgment on the possible date of exposure, and might lead to significant errors. On the other hand, interval censoring–based methods are able to utilize a much larger set of traveling data but may encounter biased sampling problems. The distribution of generation time is usually approximated by observed serial intervals. However, it may result in a biased estimation of generation time, especially when the disease is infectious during incubation. In this paper, the theory from renewal process is partially adopted by considering the incubation period as the interarrival time, and the duration between departure from Wuhan and onset of symptoms as the mixture of forward time and interarrival time with censored intervals. In addition, a consistent estimator for the distribution of generation time based on incubation period and serial interval is proposed for incubation‐infectious diseases. A real case application to the current outbreak of COVID‐19 is implemented. We find that the incubation period has a median of 8.50 days (95% confidence interval [CI] [7.22; 9.15]). The basic reproduction number in the early phase of COVID‐19 outbreak based on the proposed generation time estimation is estimated to be 2.96 (95% CI [2.15; 3.86]).
Experience of Treatment and Adherence to Cognitive Behavioral Therapy for Insomnia for Patients with Depression: An Interview Study

ABSTRACT Objective/Background Research supports the efficacy of Cognitive Behavioral Therapy for Insomnia (CBT-I) for patients suffering from depression and insomnia, but little is known about how they experience treatment and adhere to it. Our objective, therefore, was to explore how patients with depression experience treatment components and how their experiences influence adherence to CBT-I as a full-package treatment. Participants/Methods Twelve patients with depression and comorbid insomnia were interviewed after six sessions of CBT-I, and a conventional qualitative content analysis was conducted. Results Two themes were found. The theme “I picked what I needed” showed that participants chose among CBT-I methods. Behavioral methods were considered hard but so effective that they reduced the need to learn other methods. Participants had difficulty learning cognitive methods, such as the restructuring of negative thoughts, owing to lack of energy and cognitive problems aggravated by sleep loss. Sleep hygiene education was regarded as common knowledge. The theme “Staying on track” highlighted factors promoting adherence, such as a preference for non-pharmacological treatment, rapid improvement, and support from relatives and therapists. Factors impeding adherence were: a perceived lack of support from the ongoing group setting, side effects of medication, changes in daily routine, and daytime fatigue influencing cognitive and emotional functioning. Conclusion The study suggests: focusing on adherence throughout treatment; actively using support from relatives and therapists; preferring individual treatment; and prioritizing behavioral treatment components, with cognitive components introduced later in the treatment course when the negative effects on cognitive functioning due to sleep restriction have diminished.
Serial evaluation of swallowing function in a long-term survivor of V180I genetic Creutzfeldt-Jakob disease

ABSTRACT Swallowing function in long-term survivors with Creutzfeldt-Jakob disease (CJD) remains unknown. Herein, we demonstrated serial evaluation of swallowing function in a case with V180I genetic CJD (gCJD) using videofluoroscopic examination of swallowing (VF). A 69-year-old woman was admitted to our hospital because of bradykinesia and memory disturbances 4 months after the onset of symptoms. Neurological examination revealed dementia, bradykinesia and frontal signs. Diffusion-weighted MRI revealed bilateral cortical hyperintensity in the frontal, temporal, and parietal cortices, and PRNP gene analysis indicated a V180I mutation. Her dysphagia gradually progressed, and she received percutaneous gastrostomy 42 months after the onset. VF was performed at 27, 31, 39, and 79 months after the onset. Although bolus transport from oral cavity to pharynx gradually worsened and initiation of the pharyngeal swallow was gradually delayed, the pharyngeal swallowing function was preserved even at 72 months after onset. MRI revealed no apparent atrophy of brainstem, and single photon emission computed tomography showed preserved regional cerebral blood flow in the brainstem. These findings suggest that the pathophysiology of dysphagia in a long-term survivor of V180I gCJD is that of pseudobulbar palsy, likely owing to preserved brainstem function even in the akinetic mutism state.
Pharmacy services and role development in UK general practice: a cross-sectional survey.

BACKGROUND The 'Clinical Pharmacists in General Practice' (CPGP) pilot provided a template for general practice pharmacy professionals' (GPPPs) roles encouraging NHS England to fund >2000 practice-based pharmacists. However, many GPPPs work outside the CPGP initiative and little is known about the services they provide. OBJECTIVES To explore services provided by all UK GPPPs (pharmacists/pharmacy technicians), including the types of services, perceived benefits and barriers to role development. METHODS A 26-item electronic questionnaire was developed using SurveyMonkey and piloted during cognitive interviews. A cross-sectional survey was conducted via social media, primary care organisations and emails to CPGP pilot sites between November 2018 and March 2019. Three reminders were sent 1 week apart. KEY FINDINGS Ninety-one complete responses were received (81 pharmacists; 10 technicians). Over 80% of pharmacists provided clinical services, such as medication reviews or management of long-term conditions. More pharmacists within CPGP pilot managed repeat prescribing requests (P = 0.035). Technicians took responsibility for primarily non-clinical roles, including commissioning or safety alerts/drug recalls. A third of GPPPs wished to develop care home services. Perceived benefits of GPPPs' services included improved utilisation/development of professional skills, identifying medicines-related issues and reduction in medication waste. Respondents were satisfied with professional relationships but reported workload issues, limited patient awareness of their roles and restricted opportunities to contribute to service development, which was associated with unsatisfactory support/mentorship (P < 0.001). CONCLUSION General practice pharmacy professionals deliver clinical and non-clinical services which may benefit patients, general practice and the healthcare system. General practices and national organisations should provide GPPPs with tailored support and exploit the combined strengths of pharmacists and pharmacy technicians to tackle increased workload.
Association of IL-33 gene rs16924159 polymorphism and recurrent pregnancy loss in Iranian Azeri women

Abstract Background Recurrent pregnancy loss (RPL) referred to two or more consecutive abortions before 20th week of pregnancy. The imbalance of inflammatory factors such as interleukins (IL) can be a significant factor in the RPL. The aim of this study was to investigate association of interleukin-33 (IL-33) gene rs16924159 polymorphism and RPL in Iranian Azeri women. Materials and methods This case-control study consisted of 100 women with RPL as case group and 100 healthy controls with successful delivery. Genomic DNA was extracted from whole blood samples using salting out method. The fragments of the rs16924159 polymorphism were amplified by PCR and the genotyping was performed using DNA sequencing. Results The obtained results showed that frequency of GA genotype and G allele of rs16924159 polymorphism in the case group was significantly more than healthy controls (p = 0.033). Conclusions Generally, we showed that the IL-33 gene rs16924159 polymorphism may play an important role in risk of RPL in the Iranian Azeri women. However, further studies on different races and geographic areas can be useful in identification of effects of rs16924159 polymorphism on RPL.
Intergenerational Music Making

Three older Australians’ active engagement in music making with children was examined in this phenomenological study. Intergenerational music engagement was explored, focusing on the perspectives of the older Australians engaged in these musical interactions and, in particular, perceived benefits in being part of these musical interactions. Data were gathered through a series of open-ended, one-on-one interviews. Analysis of the data revealed five key themes about intergenerational (IG) music engagement: (1) IG music experiences promoted social engagement; (2) IG music experiences fostered the development of positive attitudes about young people; (3) choice in music making was valued in the IG music experiences; (4) involvement in IG music experiences resulted in the older Australians feeling valued and respected; and (5) there was the perception of reciprocity in the learning that occurred in the IG music experiences. Implications of intergenerational music engagement for music education are discussed.
Ubiquitin-based sperm assay for the diagnosis of male factor infertility

Sperm morphology is correlated with fertility in men, yet the existing, subjective sperm morphology assays provide only a limited insight into patients' infertility. Here, we provide the experimental background for a new, objective and automated semen assay, based on the cross-reactivity of defective human spermatozoa with antibodies against a proteolytic marker peptide, ubiquitin. Using immunofluorescence and flow cytometry, we screened the spermatozoa from 17 infertility patients and two fertile donors for their cross-reactivity with anti-ubiquitin antibodies. Thirteen out of 17 patients, but neither of two fertile donors, displayed an increased binding of anti-ubiquitin antibodies to sperm surface, that reflected the occurrence of abnormalities in these samples and was corroborated by available clinical data. Highest correlation coefficient (r = -0.432) was obtained with the cleavage rate after IVF. The contribution of male factor was revealed in several couples previously diagnosed with idiopathic infertility. Ubiquitin-cross-reactive sperm-surface proteins thus seem to be a universal marker of semen abnormalities, including sperm head and tail defects and semen contaminants such as spermatids, leukocytes and cellular debris. We propose that the sperm-ubiquitin tag immunoassay (SUTI) may be a valuable diagnostic tool in treatment of male factor and idiopathic infertility.
Indigenous yak and yak-cattle crossbreed management in high altitude areas of northern Nepal: a case study from Rasuwa district.

This paper summarizes and documents the indigenous yak and chauri managements in high altitude mountainous areas of Nepal through on-the-spot surveys on the farmers from three villages of case study site, Rasuwa district, 35 households were surveyed with open-ended and pre-tested questionnaires, 20 key persons were interviewed with face-to-face conversation and 47 participants were involved in participatory rural assessment (PRA), transhumance characterized by the seasonal movements of livestock between different ecological belts is key grazing pattern in the case sites. Rotational grazing of the pasturelands according to feed availability is the example of deployment of indigenous knowledge adapted by local farmers. Cross breeding of yak with cattle (Tibetan cattle bull or Zebu cattle cow) is popular in traditional herd farming system. The breeding patterns in local yak farming systems reflect the seasonal availability and climatic variation, matching very well to transhumant grazing strategies. Supplementing the herd with a small amount of concentrates in harsh lean period is the traditional feeding management. F1 hybrid calf is carefully reared and F2 hybrid calf is killed by carelessly rearing is an indigenous practice to improve the herd productivity. Careful grazing management and herbal remedies for various diseases, pests and plant poisoning are good examples of indigenous knowledge in animal health care, although the interview and survey results indicate that most farmers believe their indigenous livestock managements are moderately efficient, there are still some problems and limitations for optimizing their yak and chauri management systems. More public supports are expected by local farmers to improve yak and chauri production systems, the potential indigenous industries in remote mountainous areas. It can be recommended and suggested from this case study that making better use of the vast indigenous knowledge that the local farmers possess is necessary when making improved management plans for yak and chauri farming system. Participatory research, policy-making and extension network should be developed to encourage the farmers to work together with professionals for better integrating the indigenous skills with advanced technologies. Indigenous institution development and farmers’ capacity building are imperative for better planning and successful implementation of livestock management program. Key words: Indigenous knowledge, yak and hybrids, management system.
Fatigue in Adults with Type 2 Diabetes: A Systematic Review and Meta-analysis

This review aimed to evaluate the level of fatigue in adults with type 2 diabetes measured by the validated Diabetes Symptom Checklist (DSC)and related factors. Ten studies were included. Both DSC (n = 4) and the revised (n = 6) have been used to measure fatigue. When the latter was used (n = 1082), the pooled level of fatigue was 1.77 (on a 0–5 scale). When the former was used (n = 674), the pooled level of fatigue was 1.73 (on a 0–10 scale). Participant demographics (e.g., gender), health information (e.g., BMI), and diabetes-specific factors (e.g., A1C and diabetes distress) were associated with fatigue. Fatigue was negatively related to self-care behaviors. The prevalence of significant fatigue remains unclear due to a lack of a cut-off point of the instrument. Future research is warranted to identify the threshold for clinically significant fatigue and investigate the causal relationship. Nurses are recommended to perform a routine assessment of fatigue.