Miracle-dz/UniFAR-FTUs huggingface dataset:
The current outlook of human papillomavirus and its association with digestive tract cancer

Digestive tract cancers are frequent worldwide, despite efforts to control known predisposing factors, they keep increasing, this fact suggests that human papillomavirus (HPV) may play an important oncogenic role in these pathologies. In order to argue the incidence that HPV has in the genesis of gastrointestinal tract tumors and to determine if it is a possible causal agent, the scientific literature published to date on the subject was reviewed, and was found that 4.5% of all diagnosed cancers correspond to HPV; 12% are extra cervical, 20% esophagus, 31.9% colon adenomas, 43% colorectal adenocarcinoma, and 35% head and neck neoplasms (HNSCC). The types of HPV reported in the digestive tract are 6, 9, 11, 13, 16.18, 20, 24, 25, 30, 33, 51, 54, 57, DL 416, DL 428 and DL 436. Although, the studies show the HPV impact in the oncogenesis and its role as a prognostic marker in some of them, they do not have hard evidence that reveals this relationship, therefore demonstrating its integration would allow clarifying it.
Butyrate Regulates COVID-19-Relevant Genes in Gut Epithelial Organoids From Normotensive Rats.

It is increasingly evident that patients with hypertension are at high risk for coronavirus disease 2019 (COVID19) and exhibit gastrointestinal symptoms suggesting that impaired gut-lung communications could be responsible, at least in part, for the multiorgan pathologies including cardiovascular manifestations of this disease.1 Higher expression of ACE2 (angiotensin-converting enzyme-2) and TMPRSS2 (transmembrane protease serine-2), key molecules in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection, in gut epithelium from spontaneously hypertensive rats supports this view.2 Finally, changes in gut microbiome associated with short-chain fatty acids, particularly butyrate, is found in both hypertension and COVID-19.1 Butyrate is an HDAC (histone deacetylase) inhibitor that maintains acetylation of histones, affecting chromatin organization and gene expression. Therefore, we sought to test the hypothesis that increased risk of COVID-19 in hypertension could, in part, be due to cumulative depletion of butyrate-producing gut bacteria leading to decreases in butyrate.1 Therefore, treatment with this short-chain fatty acid would regulate ACE2 and its partners influencing antiviral genes. This could be critical in the control of gut viral infection and rebalancing of the gut-lung axis.
Cognitive Frames of Poverty and Tension Handling in Base-of-the-Pyramid Business Models

Base-of-the-pyramid (BOP) business models aim to achieve profitability and poverty reduction by including poor people into corporate value chains. This goal duality creates tensions. Actors’ responses to these tensions are influenced by their cognitive frames of the phenomena building the tension. Applying a cognitive perspective, I investigate how corporate actors with different frames of poverty respond proactively or defensively to the poverty–profitability tension by adapting business model elements. I find that proactive and defensive responses differ for actors holding different cognitive frames of poverty. The responses have consequences for the poverty impact potential of BOP business models.
AN EMPIRICAL INVESTIGATION OF THE ASSOCIATIONS OF SHORT AND LONG DEBT POLICIES WITH’ ECONOMIC VALUES OF ENERGY SECTOR

The purpose of this paper is to empirically investigate the impact of short and long-term debt policies on economic values of energy sector in Saudi Arabia. Pooled OLS Regression model is utilized to analyze 8 years of energy companies’ data (2012-2019) to report the association between two measures of capital structure, namely; short-term and long-term debt policies, and firm economic value after controlling for firm size and inventory management. Empirical findings suggest that the two measures of capital structure impact negatively on firm economic value in energy industry in Saudi Arabia. The results of this study have several policy implications for financial managers, banks, investors, auditors, and stock market authority to understand why capital structure impacts the firm sustainability in a negative way.
Sonochemical synthesis of aragonite-type calcium carbonate with different morphologies

Aragonite, a high-pressure polymorph of CaCO3, was synthesized for the first time from simple Ca(HCO3)2 solutions by using high-power ultrasound irradiation. XRD, FT-IR and SEM techniques were used to characterize the phase composition and morphology of the products. The intensity of the ultrasound irradiation was found to have a remarkable effect on the morphology of the as-synthesized aragonite. The morphology evolved from rod-shaped to spindle-shaped when the acoustic amplitude is increased from 50% to 70% of the full amplitude. A possible mechanism for the formation of this controllable aragonite formation is proposed. The dissolved CO2 plays a crucial role in the homogeneous nucleation and growth of aragonite under sonication. Vaterite with flower- or dendrite-like structures could also be obtained by using 75% or 80% of the full acoustic amplitude, respectively. A nonequilibrium kinetics process controls the formation of unstable vaterite with unusual structures.
A Systematic Review of Metal Oxide Applications for Energy and Environmental Sustainability

Energy is the fundamental requirement of all physical, chemical, and biological processes which are utilized for better living standards. The toll that the process of development takes on the environment and economic activity is evident from the arising concerns about sustaining the industrialization that has happened in the last centuries. The increase in carbon footprint and the large-scale pollution caused by industrialization has led researchers to think of new ways to sustain the developmental activities, whilst simultaneously minimizing the harming effects on the enviroment. Therefore, decarbonization strategies have become an important factor in industrial expansion, along with the invention of new catalytic methods for carrying out non-thermal reactions, energy storage methods and environmental remediation through the removal or breakdown of harmful chemicals released during manufacturing processes. The present article discusses the structural features and photocatalytic applications of a variety of metal oxide-based materials. Moreover, the practical applicability of these materials is also discussed, as well as the transition of production to an industrial scale. Consequently, this study deals with a concise framework to link metal oxide application options within energy, environmental and economic sustainability, exploring the footprint analysis as well.
Dynamic Multipole Polarizabilities of Helium and Screened-Helium Atoms

The precise estimation of atomic polarizabilities impinges upon a number of areas and processes in physical science. We calculate precisely the dynamic multipole polarizabilities of the helium and screened-helium atoms using highly correlated exponential wavefunctions based on the pseudo-state summation method. For screened environments, we consider the Debye–Hückel potential (DHP) as the interaction potentials between the charged particles. The dynamic multipole (quadrupole, octupole, and hexadecapole) polarizabilities for the ground state of the helium atom and the multipole (quadrupole and octupole) polarizabilities of the screened-helium atom for different screening parameters are reported along with magic-zero wavelengths. The reported results for hexadecapole polarizability of the helium atom and dynamic multipole polarizability of the screened-helium atom are new and would be useful for future investigation on this topic.
Specific heat of cubic relaxor ferroelectrics

The specific heat has been measured for the relaxor ferroelectrics PbMg1/3Nb2/3O3 and PbMg1/3Ta2/3O3 and the low-dielectric-constant material BaMg1/3Ta2/3O3 over a temperature range of 2–420 K. The behaviours of the specific heat for PbMg1/3Ta2/3O3 and BaMg1/3Ta2/3O3 crystals have been qualitatively compared. A large excess of specific heat of PbMg1/3Ta2/3O3 over that of BaMg1/3Ta2/3O3 has been revealed. The behaviour of the low-temperature specific heat of PbMg1/3Nb2/3O3 has been analysed in the frameworks of the shell model, Debye model, Einstein oscillator, two-level systems approach, and fractal approach. The excess of the specific heat of PbMg1/3Nb2/3O3 over the harmonic phonon contribution has been estimated, and its possible origin is discussed.
Performance of a Semiquantitative Multiplex Bacterial and Viral PCR Panel Compared With Standard Microbiological Laboratory Results: 396 Patients Studied With the BioFire Pneumonia Panel

Abstract Background Microbiologic results are critical to optimal management of patients with lower respiratory tract infection, but standard methods may take several days. The multiplex polymerase chain reaction BioFire Pneumonia (PN) panel detects 15 common bacterial species semiquantitatively as copy number/mL, 8 viral species, and 7 resistance genes in about an hour within the clinical laboratory. Methods We tested 396 unique endotracheal or bronchoalveolar lavage specimens with the BioFire Pneumonia panel and compared the bacterial detections to conventional gram stain and culture results. Results Of the 396 patients, 138 grew at least 1 bacterium that had a target on the PN panel, and 136/138 (98.6%) were detected by the panel. A total of 177 isolates were recovered in culture and the PN panel detected 174/177 (98.3%). A further 20% of patients had additional targets detected that were not found on standard culture (specificity 69%, positive predictive value 63%, and negative predictive value 98.9%). Copy number was strongly related to standard semiquantitative growth on plates reported by the laboratory (eg, 1+, 2+, 3+ growths) and was significantly higher in those specimens that grew a potential pathogen. Both higher copy number and bacterial detections found by the PN panel, but not found in culture, were strongly positively related to the level of white blood cells reported in the initial gram stain. Conclusions Higher copy number and bacterial detections by the PN panel are related to the host respiratory tract inflammatory response. If laboratories can achieve a rapid turnaround time, the PN panel should have a significant impact both on patient management and on antibiotic stewardship.
A comparative study on atomic transport properties of liquid less-simple metals

We have studied the atomic transport properties of liquid less-simple metals namely Bi, Cd, Pb, Sb, Sn and Tl using universal scaling laws and hard sphere (HS) theories of liquid. Effective interionic interaction in metals has been derived from both Brettonet–Silbert (BS) and Ashcroft’s empty core pseudopotential models. For structure calculation, variational modified hypernetted chain integral equation theory has been considered. Excess entropy and effective HS diameter are the basic ingredients of the study. Obtained ingredients are found to be close with experimental data than any other available literature values when BS model has been chosen. Comparing with experimental data, obtained results for transport coefficients suggest that Faber’s HS theory is excellent for diffusion coefficient and is reasonably good for viscosity coefficient along with BS pseudopotential than any other combinations employed in this study. The probable reason may be the hybridization of s and d electrons exists in the concerned systems.
Analisis Dasar Teologi terhadap Pelaksanaan Ibadah Online Pascapandemi Covid-19

The development of digital technology has made the world change, forcing the church to also change the pattern of its ministry, coupled with the Covid-19 pandemic conditions, the church has changed services that require physical meetings to become online services. This raises pros and cons because it does not yet have an adequate theological foundation, so this research is conducted to analyze and explore the principles of Worship theology, in particular, to answer what is the theological basis of the implementation of online worship. The method used is the literature review method in order to get theological writing. Based on this research, it was found that online worship has a theological basis and can still be carried out after the Covid-19 pandemic ends. This is important so that the church is not left behind and left behind by the progress of the times. Abstrak Perkembangan teknologi digital telah membuat dunia berubah sehingga memaksa gereja juga harus ikut mengubah pola pelayanannya, ditambah dengan kondisi Pandemi Covid-19 membuat gereja mengubah pelayanan yang mengharuskan pertemuan fisik menjadi pelayanan secara online. Hal ini menimbulkan pro dan kontra karena belum memiliki landasan teologis yang memadai, sehingga penelitian ini dilakukan untuk menganalisa dan menggali prinsip teologi Ibadah khususnya menjawab apa dasar teologis dari pelaksanaan Ibadah online. Metode yang digunakan adalah metode tinjauan literatur guna mendapatkan tulisan yang bersifat teologis. Berdasarkan penelitian ini ditemukan bahwa ibadah online memiliki dasar teologis dan tetap boleh dilaksanakan setelah pandemi Covid-19 berakhir. Hal ini penting supaya gereja tidak ketingalan dan ditinggal oleh kemajuan zaman
Frequency of leptospirosis in horses in Manaus and metropolitan region in Amazonas State, Brazil

The occurrence of leptospirosis is significantly higher in the tropical climate than in temperate regions, especially in periods with high rainfall levels. In horses, leptospirosis can range from subclinical to asymptomatic but maintains an important role in the transmission of leptospirosis by eliminating the agent in the environment. Regarding horses, the Amazonas herd increased by 30% between 2004 and 2013. Thus, the study aimed to determine the serological prevalence of leptospirosis in horses in Manaus and metropolitan regions, in the State of Amazonas, Brazil as well as to assess the main serogroups involved in the infections of these animals. For this purpose, from August 2018 to July 2019, serum from 198 horses was evaluated through the microscopic agglutination test with a panel of 10 serogroups. As a result, 92 horses (44.46%) were found to be positive for one or more Leptospira serovars, with the highest prevalence of serogroups Icterohaemorrhagiae and Pyrogenes. Therefore, with the increase in the equine herd in the region and, consequently, greater interaction between breeders and animals, the identification of reagents to at least one serovar of Leptospira spp. signals the possible existence of reservoirs of pathogenic strains for other animals and man.
Prevalence of pelvic floor dysfunction in women attending obstetrics and gynaecology OPD at PES Institute of Medical Sciences asnd Research, Kuppam

The pelvic floor in females is required for various functions which include parturition, urination and urinary continence, defecation and faecal continence, pleasure and sexuality. Pelvic floor functions are controlled by the central nervous system and could be impaired due to anatomical injury or neurological dysfunction. Pelvic floor dysfunction is also referred to as pelvic floor disorders or pelvic floor weakness. Pelvic floor dysfunction is manifested as urinary incontinence (UI), faecal incontinence (FI), and pelvic organ prolapse (POP). The prevalence of PFD is estimated to be in the range of 12 to 42% and increases with age. PFDs are usually associated with a high number of pregnancies and heavy lifting. The tendency to develop PFDs increases with age due to the weakening of pelvic floor muscles mostly after the age of 55 years. With the advancement of age, the probability of pelvic floor dysfunction, particularly urinary or faecal incontinence increases. Among various risk factors of pelvic floor dysfunction, pregnancy and childbirth are considered to have a major ABSTRACT
Numerical Analysis of the Rudder–Propeller Interaction

The proper evaluation of the Rudder–Propeller interactions is mandatory to correctly predict the manoeuvring capability of a modern ship, in particular considering the commonly adopted ship layout (rudder often works in the propeller slipstream). Modern Computational Fluid Dynamics (CFD) solvers can provide, not only the performance of the whole system but also an insight into the flow problem. In the present paper, an open-source viscous flow solver has been validated against available literature experimental measurements in different conditions. After an extensive analysis of the numerical influence of the mesh arrangement and the turbulent quantities on the rudder provided forces, the study focused its attention on the forces generated by the rudder varying the propeller loading conditions and the mutual position between the two devices. These analyses give a hint to describe and improve a commonly-used semi-empirical method based on the actuator disk theory. These analyses also demonstrate the ability of these numerical approaches to correctly predict the interaction behaviour in pre-stall conditions with quite reasonable computational requests (proper also for a design stage), giving additional information on the sectional forces distribution along the span-wise rudder direction, useful to further develop a new semi-empirical rudder model.
Gender in Unilingual and Mixed Speech of Spanish Heritage Speakers in The Netherlands

This study examines heritage speakers of Spanish in The Netherlands regarding their production of gender in both their languages (Spanish and Dutch) as well as their gender assignment strategies in code-switched constructions. A director-matcher task was used to elicit unilingual and mixed speech from 21 participants (aged 8 to 52, mean = 17). The nominal domain consisting of a determiner, noun, and adjective was targeted in three modes: (i) Unilingual Spanish mode, (ii) unilingual Dutch mode, and (iii) code-switched mode in both directions (Dutch to Spanish and Spanish to Dutch). The production of gender in both monolingual modes was deviant from the respective monolingual norms, especially in Dutch, the dominant language of the society. In the code-switching mode, evidence was found for the gender default strategy (common in Dutch, masculine in Spanish), the analogical gender strategy (i.e., the preference to assign the gender of the translation equivalent) as well as two thus far unattested strategies involving a combination of a default gender and the use of a non-prototypical word order. External factors such as age of onset of bilingualism, amount of exposure and use of both languages had an effect on both gender accuracy in the monolingual modes and assignment strategies in the code-switching modes.
Osteopontin-c isoform inhibition modulates ovarian cancer cell cisplatin resistance, viability and plasticity

Osteopontin (OPN) is upregulated in several types of tumor and has been associated with chemoresistance. However, the contribution of OPN splicing isoforms (OPN-SIs) to chemoresistance requires further investigation. The present study aimed to evaluate the expression patterns of each tested OPN-SI in cisplatin (CDDP)-resistant ovarian carcinoma cell lines, focusing on the role of the OPN-c isoform (OPNc) in drug resistance. ACRP ovarian cancer cells resistant to CDDP, as well as their parental cell line A2780, were used. Analyses of the transcriptional expression of OPN-SIs, epithelial-mesenchymal transition (EMT) markers and EMT-related cytokines were performed using reverse transcription-quantitative PCR. OPNc was silenced in ACRP cells using anti-OPNc DNA oligomers and stably overexpressed by transfecting A2780 cells with a mammalian expression vector containing the full length OPNc cDNA. Functional assays were performed to determine cell proliferation, viability and colony formation. The results demonstrated that among the three tested OPN-SIs, OPNc was the most upregulated transcript in the ACRP cells compared with the parental A2780 cells. In addition, the expression levels of P-glycoprotein multidrug transporter were upregulated in CDDP-resistant ACRP cells compared with those in A2780 cells. OPNc knockdown sensitized ACRP cells to CDDP treatment and downregulated P-gp expression levels compared with those in the negative control group. Additionally, silencing of OPNc impaired cell proliferative and colony formation abilities, as well as reversed the expression levels of EMT markers and EMT-related cytokines compared with those in the negative control cells. Notably, although stable OPNc overexpression resulted in increased A2780 cell proliferation, it notably increased CDDP sensitivity compared with that in the cells transfected with a control vector. These results suggested that OPNc silencing may represent a putative approach to sensitize resistant ovarian cancer cells to chemotherapeutic agents.
EVALUATING THE LEGIBILITY OF COMPLEX BUILDINGS: A QUANTITATIVE MODEL FOR INDOOR WAYFINDING

Wayfinding presents a significant aspect in architectural design since it is associated with the spatial organization and the legibility of indoor environments. It is believed that the physical characteristics of the indoor environment influence the performance of individuals in finding their way in complex settings. Navigation in such buildings can be a distressing process if the needed spatial information is not clearly presented to users; hence, it is important during the design phase to consider the factors that affect users’ wayfinding performance. This paper examines these factors in indoor environments and focuses on the design variables that influence their legibility. Furthermore, it attempts to develop a quantitative evaluation model that assesses wayfinding in complex buildings in terms of their architectural design variables, through assigning weights of importance to these variables. For the purpose of implementing and testing the evaluation model, two case studies were conducted in shopping centers in Cairo, Egypt. The performance of users during the study was found to be consistent with the results of the evaluation model. This suggests that the assigned weights of the design variables were rather logical. These weights help in defining the design priorities for wayfinding: building configuration and its complexity are regarded as the first priority, followed by architectural differentiation, visual accessibility, and lastly, landmarks.
Simulation Studies on Variable Cluster Size in FCC Riser Reactor

Cluster baser fluid catalytic cracking (FCC) riser models are widely used for studying the effect of operating conditions on the products yields. Cluster size is an important parameter that influences the particle residence time, heat and mass transfer coefficients, and product yields in the FCC riser. In most cluster based models a constant cluster size (6 mm) is used. In the present work, various correlations for the prediction of cluster size as a function of local flow conditions are compared. The results show significant variation in conversion, and yields of gasoline and coke for these correlations. Coke yield prediction is most influenced by the cluster size.