Miracle-dz/UniFAR-FTUs huggingface dataset:
International Journal of Biopharmaceutics

Several N-(heterocyclic)-1H-isoindole, were prepared from hydrazine carboxylic acid-1,3-dioxo-1,3-dihydroisoindole-2-yl ester for the purpose of possible genotoxic activity against cancer cell line of mouse spleen. In conclusion, the correlation between chromosomal aberrations induction, suppression of proliferation rate and antitumor activity observed in this study, appeared to further substantiate the validity of the chromosomal aberration assay as a possible method for improving and guiding chemotherapy.
Levobupivacaine induces vasodilatation, but not vasoconstriction, in rat mesenteric artery

Introduction Levobupivacaine (LEVO) can replace analgesia because it exhibits low toxicity and causes minor vasoconstriction, enabling its use in patients in whom vasoconstrictors are contraindicated. Objective We aimed to evaluate the effects of LEVO in isolated rat superior mesenteric artery by using the vascular reactivity technique and compare its effect to that of lidocaine. Material and method Arterial rings were obtained from the mesenteric artery of male Wistar rats and kept in organ baths. For recording isometric contractions, each ring was suspended by cotton threads from a force transducer, which was connected to a data acquisition system. Result Both lidocaine and LEVO did not show a vasoconstrictor effect on the basal tone of the arterial rings with functional endothelium. However, when the rings were pre-contracted with phenylephrine, both drugs were able to induce concentration-dependent vasodilatation. The vasodilator effect induced by LEVO did not change after removal of the endothelium, or with the addition of tetraethylammonium (1 mM), a non-selective K+ channel blocker. In the rings without functional endothelium, which were pre-contracted with depolarizing Tyrode’s solution (KCl 80 mM), LEVO-induced vasodilatation was not significantly different from that observed in the rings pre-contracted with phenylephrine. Moreover, it did not show a significant additional vasodilator effect compared to the maximal vasodilator effect of nifedipine. Conclusion This study demonstrated that LEVO produces a vasodilator effect in the rat superior mesenteric artery in an endothelium-independent manner. This effect seems to be mediated via Ca2+ channel blockade in the vascular smooth muscle cells.
Orbital inflammatory disease management

ABSTRACT Introduction: Orbital inflammatory disease (OID) represents a spectrum of conditions that can be placed into two groups, specific orbital inflammatory disease (SOIS) and nonspecific orbital inflammatory disease (NSOIS). This manuscript aims to systematically review the therapies for the different types of OID. Areas covered: The therapy for OID has evolved significantly with the advent of biologic medications, although certain mainstays are still widely used. The authors conducted a review of literature published in the last 20 years with the use of PubMed. This article is organized according to disease syndrome. Specific diseases and their associated treatments are addressed. Expert commentary: Although corticosteroids are still the mainstay of treatment in most OID, a focus on disease specificity combined with increasing understanding of inflammatory pathways has allowed utilization of inflammatory modulatory medications. Investigating these therapeutics in prospective trials will likely be the vital link to improving patient care in orbital inflammatory disease.
STUDIES OF SALINITY AND DROUGHT ON COMMON BEAN

Two pot experiments were carried out in the farm of Fac. of Agric. ; MansouraUniversity during the two successive summer seasons of 2008 and 2009, to investigate the effect of soil salinity Proline treatments and some irrigation levels on plant growth, yield and biochemical constituents of Common bean (Phaseolus vulgaris L.). cv. Nebrasca. The results obtained can be summarized as follows:- 1-Vegetative growth of common bean in term of plant height, number of leaves, fresh weight, dry weight and leaf area was reduced in case of growing on saline clay soil in both seasons. 2- Decreasing the number of irrigation gave rise to decrease vegetative growth in both seasons. 3- Proline treatment caused positive effect on the leaves. 4- The triple interaction had no significant effect on all parameters of vegetative growth in both years except leaf area in the second year. 5- Saline soil had deleterious effect on flowering parameters on both years. Likewise, decreasing irrigation number lead to injuring effect on flowering parameters while proline treatment had no obvious increase in this respect. 6- Triple interaction had no effect on flowering parameters on both years. 7- Almost NPK concentrations as well as Na, Ca, Mg were reduced in case of saline soil in both years. 8- Decreasing irrigation number decreased mineral contents of common bean leaves in both years, while proline treatment lead to increase mineral concentration in both years. 9- Saline soil had injurious effect on chlorophyll contents in both seasons. Likewise, decreasing irrigation number caused a significant decrease in pigment content in both years. Otherwise, proline treatment caused an increase in pigments content in both years.
CEMENT-BONDED PLYWOOD ( CBPLY )

The use of wood composites for interior design is especially limited by the formaldehyde emission and flammability of the material. Plywood, the world wide most significant wood-based panel, is mostly made by formaldehyde-based amino resins (e.g. UF and PF resins). Without expensive additives or coatings, plywood can’t comply with many emission standards and fire protection limits. In this study, formaldehyde-free Ordinary Portland cement (OPC) is presented as a binder for wood veneers. OPC is widely available, inexpensive and is in use in various industries, including the wood-based panel industry (e.g. cement-bonded particle boards = CBPB). The bending properties, formaldehyde emission, and flammability of the laboratory manufactured cement-bonded plywood (CBPly) were tested. The results indicate that the formaldehyde emission and the flammability of plywood bonded by OPC were much lower than those of plywood bonded by formaldehydebased resin. The bending properties of CBPly can’t compete with those of organic bonded plywood, yet. However, the bending values of CBPly clearly exceed those of CBPB. The new product CBPly combines the advantages of organic-bonded plywood (e.g. high strength, low density) and CBPB (e.g. low formaldehyde emission, high fire resistance). With these properties, CBPly is expected to be increasingly used in markets that are difficult or inaccessible for organic-bonded plywood and CBPB.
Detection of Brain Tumor Based on Extraction Feature Vectors

It is a critical task for diagnosis and curing the brain tumour. The diagnosis of brain tumor requires a fast and efficient way to classify it through multiple stages. It is the aim of the paper to proposed a system for diagnosis the disease. MRI of brain as input is normalized. Next extraction of feature vectors from the image is made to reduce the redundancy of data for the classifier. Finally, each tuple of feature extracted vector is used for producing classified output. The proposed methodology is performed very efficiently and accurately.
Study on Driving Cycle Synthesis Method for City Buses considering Random Passenger Load

This paper proposes a novel driving cycle construction method in consideration of velocity, road slope, and passenger load, based on a real-world bus route with a plug-in hybrid electric bus (PHEB). The main purpose is to address the disadvantage that an inaccurate reflection of the real-world driving characteristics for city buses will be caused when ignoring the passenger load in the course of a driving cycle synthesis. Two contributions are supplemented to distinguish from the previous research. Firstly, a novel station-based method is proposed aiming at developing a driving cycle with high accuracy. The kinematic segments are partitioned according to the distance of adjacent bus stops, while a two-dimensional Markov chain Monte Carlo method is employed to synthesize driving cycle between each interval of adjacent bus stops. Secondly, the random passenger load for different bus stops is treated as a discrete Markov chain model, according to the correlation analysis of the measured passenger data which are distinguished for off-peak and peak hours. Meanwhile, Monte Carlo simulation and maximum likelihood estimation are utilized to determine the most likely number of passengers for each bus stop. At last, the fuel consumption of the PHEB is simulated with the best-synthesized driving cycle and contrasted to the mean fuel consumption of the later measured data which is composed of the velocity, road slope, and the passenger load. The results demonstrate that the synthesized driving cycle has a higher accuracy on fuel consumption estimation.
Noticing and Helping Neglected Children in Scotland: 'sometimes it's just too hard to talk'

This paper sets out the policy context for noticing and helping neglected children in Scotland. The overarching framework, Getting it Right for Every Child, now enshrined in legislation, provides the context for a response to a broad range of concerns about children whose needs may not be fully met. Supportive and protective responses are required of those working in the universal services and in targeted services with the aspiration of providing seamless services for children. The paper reports on evidence gathered in a review of neglect in Scotland and draws on the views of children gathered as part of a review in the UK to explore the nature of the response to neglected children in Scotland. The paper suggests that Scotland is in a strong position to develop a holistic framework to tackle neglect but that a number of tensions need to be addressed to ensure this direction of travel.
Management practices : Are not ‐ for ‐ profits different ? 1

Recent studies have demonstrated the importance of management practices for firm performance. In this paper, we focus on management practices in not‐for‐profits (NFPs) and examine how they compare with those of for‐profits (FPs) in the same industry, both in terms of their quality and their relation with performance. Using a tried and tested survey of management practices, we find that NFPs score lower on the overall management score than FPs, but nevertheless perform as well as FPs in terms of productivity and quality. We find little evidence for systematic differences between NFPs and FPs in how management practices affect performance. Lastly, we present a theory, consistent with our empirical findings, predicting that management quality will be lower in NFPs compared to FPs but that outputs may not be worse if managers are heterogeneous in ability and altruism.
Evaluation of bread prepared from composite flour of sweet lupine and Bread wheat variety

Sweet lupine is high in protein and dietary fiber. Incorporating sweet lupine flour with wheat produces more nutritious food. In the study the samples sweet lupine and wheat flour were collected from Holeta crop breeding and the bread product were made incorporating the sweet lupine (welela variety) flour with wheat flour (Dendea variety). The bread product were made with five interval from each treatment from Treatment 1 (100 wheat flour) control up to Treatment 9 (60 wheat flour: 40 sweet Lupine flour). From the bread product the nutritional and sensory data were collected. The result for the treatments Treatment1 up to Treatment6 (75 wheat flour: 25 sweet lupine flour) had high value in protein (11.68-20.74%) and Calcium, Zinc as well as color of bread (4.0-4.57) and taste Treatment 1-Treatment 6 (3.71-4.78). From all the treatments Treatment1- Treatment 6 had high nutritional and sensory result.
Binding affinity and conformational preferences influence kinetic stability of short oligonucleotides on carbon nanotubes

DNA-wrapped single walled carbon nanotubes (SWNTs) have found a widespread use in a variety of nanotechnology applications. Yet, the relationship between structural conformation, binding affinity and kinetic stability of these polymers on SWNTs remains poorly understood. Here, we used molecular dynamics (MD) simulations and experiments to explore this relationship for short oligonucleotides adsorbed on SWNTs. First, using classical MD simulations of oligonucleotide-(9,4)-SWNT hybrid complexes, we explored the relationship between ssDNA and ssRNA surface conformation and sequence chemistry. We screened the conformation of 36 sequences of short ssDNA and ssRNA polymers on (9,4) SWNT, where the contour lengths were selected so the polymers can, to a first approximation, wrap once around the SWNT circumference. From these screens, we identified structural motifs that we broadly classified into “rings” and “non-rings. ” Then, several sequences were selected for detailed investigations. We used temperature replica exchange MD calculations to compute two-dimensional free energy landscapes characterizing the conformations of select sequences. “Ring” conformations seemed to be driven primarily by sequence chemistry. Specifically, strong (n,n+2) nucleotide interactions and the ability of the polymer to form compact structures, as for example, through sharp bends in the nucleotide backbone, correlated with ring-forming propensity. However, ring-formation probability was found to be uncorrelated with free energy of oligonucleotide binding to SWNTs (ΔGbind). Conformational analyses of oligonucleotides, computed free energy of binding of oligonucleotides to SWNTs, and experimentally determined kinetic stability measurements show that ΔGbind is the primary correlate for kinetic stability. The probability of the sequence to adopt a compact, ring-like conformation is shown to play a secondary role that still contributes measurably to kinetic stability. For example, sequences that form stable compact rings (C-rich sequences) could compensate for their relatively lower ΔGbind and exhibit kinetic stability, while sequences with strong ΔGbind (such as (TG)3(GT)3) were found to be kinetically stable despite their low ring formation propensity. We conclude that the stability of adsorbed oligonucleotides is primarily driven by its free energy of binding and that if ring-like structural motifs form, they would contribute positively to stability.
Virucidal activity of WHO-recommended formulations against enveloped viruses including Zika, Ebola and emerging Coronaviruses

The World Health Organization (WHO) published two alcohol-based formulations to be used in healthcare settings and outbreak-associated infections, but inactivation efficacies of these products have not been determined against (re-) emerging viruses. In this study, we evaluated the virucidal activity of these WHO products in a comparative analysis. Zika virus (ZIKV), Ebola virus (EBOV), Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome coronavirus (MERSCoV) as (re-) emerging viral pathogens and other enveloped viruses could be efficiently inactivated by both WHO formulations implicating their use in healthcare systems and viral outbreak situations.
A study of the Impact of cultural diversity on the Technological Innovation process in the Nuclear Energy Corporations

The research paper intended to show the impact of cultural diversity on the technological innovation process in the nuclear sector in the UAE. The study is based on both of the secondary and primary resources of information. The focal emphasis areas on the paper is to show the benefits of cultural diversity in respect of innovation process, the pouring forces for nuclear technology innovation, the nuclear innovation program, the challenges of cultural diversity in respect of innovation process and the current strategies of handling cultural diversity for executing innovation process. For the primary data, it has been gathered from a sample of the staff working in the Nawah Energy Company, which has been chosen for conducting the primary research. In the present context 75 employees of the Nawah Energy Company have been chosen for collecting the quantitative data, while 3 managers of the same organization have been selected for gathering the qualitative data. The paper recommends several strategies for improving the positive impact of the cultural diversity practices in the nuclear sector to improve the innovation process in this critical sector. These included the communication cost, access of market, creative ideas, as well as, resource allocations are the highly crucial aspects of the innovation process in the nuclear sector.
Relationship between Management Accounting Innovations and Cost Performance in University

This study aims to examine the effect of management accounting innovation variables on cost performance in private universities in the provinces of West Sumatra, Riau, Riau Islands and Jambi in Indonesia. This study uses a quantitative approach in explaining the relationship between variables. Data is obtained through questionnaires from 167 heads of higher education finance and then is processed using partial least square (PLS). The results of the study indicate that management accounting innovation significantly influences the cost of performance diversity. This research contribution develops research related to cost performance and management accounting innovation. The implication of the research provides input for the management of higher education costs, especially private tertiary institutions, in improving their cost performance through management accounting innovation. The limitation of this research is only focusing on private universities in West Sumatra, Riau, Riau Islands and Jambi. Therefore, the results cannot be generalized in other regions. Keywords—Cost performance of university, management accounting innovation
Productivity of rice as influenced by irrigation regimes and nitrogen management practices under SRI

A field experiment was conducted on a clay loam soil at Indian Institute of Rice Research (IIRR), Rajendranagar, Hyderabad, Telangana during the kharif seasons of 2013 and 2014 to studay the effect of irrigation regimes and nitrogen management on rice under SRI. The Varadhan (DRR Dhan 36) variety was used in field experiment. The results revealed that the system of rice intensification proved significantly superior in terms of growth and yield parameters such as plant height, number of tillers, leaf area index, number panicles -1 , filled grains panicle -1 , test weight, grain yield and straw yield as compared to mechanized system of rice intensification. Irrigation maintained at saturation level produced significantly higher growth, yield parameters and yield which were comparable with irrigation at 3 DADPW. Application of nitrogen based on leaf colour chart registered significantly higher growth, yield parameters and yield which were at par with soil test crop response based nitrogen management practice but both these treatments were significantly superior over the RDN 75 % inorganic and 25 % organic and RDN 100 % through inorganic management practices.
I-Sounds-Emotion-based Music Composition for Virtual Environments

From the concert halls to our pockets, music has an ubiquitous presence in our lives. Due to its observable, yet not fully understood, expressive abilities, it is a very effective communication tool explored in computer games, films and virtual and interactive systems. In spite of the crescent demand for flexibility, nowadays, most applications use pre-composed soundtracks, less flexible though aesthetically refined. A new trend takes the paradigm a step further to develop automatic composition systems, able to deliver real-time contextualised music, while the user is presented with an every changing interactive experience. This work is above all an exploratory proof of concept and a step towards that objective, proposing a computational architecture and implementation for an emotion-based composition system. The goal is to provide a composition algorithm development framework, as well as, a run-time environment for integration with affective systems. In parallel, this work proposes a composition algorithm able to express happiness, sadness, anger and fear, using the properties of rhythm and diatonic modes. In conjunction both systems are expected to enlarge the affective bandwidth of an Interactive-Drama application, in which children can build up stories with the collaboration and participation of computer controlled characters. While the collected empirical data does in fact supports the hypothesis, it also uncovers some aspects requiring further refinement, such as, the illustration of anger and fear. The experiments, have also validated the I-Sounds framework as a suitable development and integration tool for composition algorithms.
Microbial and Fungal Contamination of Wheat Flour, Dough, and Bread Samples Collected from Isfahan, Iran

The present investigation was done to evaluate the microbial and fungal contamination and also molecular identification of fungal species in flour, dough and bread samples collected from Isfahan, Iran.Two-hundred and forty different types of cereals including flour, dough and bread were collected. Samples were subjected to microbial and fungal counting and also PCR-based identification of fungal species and sequencing of Aspergillus species. Ranges of total bacterial count of flour, dough and bread samples collected from breads were between 2.83±0.99 and 6.43±1.12 log cfu/g. Flour, dough and bread samples collected from bulk breads had the higher counts of total bacteria than those of flat breads. Ranges of mold count of flour, dough and bread samples collected from breads were between 0.00±0.00 and 1.63±0.63 log cfu/g. Flour, dough and bread samples collected from flat breads had the higher counts of mold than those of bulk breads.Distribution of Penicillium, Cladosporium, Mucor, Aspergillus, Alternaria, Canninghamella, Hyaline, Rhizopus, Epicoccum and Syncephalestrum amongst detected fungal colonies were 24.40%, 20.10%, 20.10%, 19.00%, 3.80%, 3.80%, 3.80%, 2.70%, 1.00% and 1.00%, respectively. Sequencing of isolated Aspergillus genus revealed that all strains were related to flavus, oryzea, terreus,andnijer species. Detected total count and mold count in studied bread samples were lower than limit standards announced by Institute of Standards and Industrial Research of Iran. However, considering the high consumption rate of these kinds of food samples among Iranian people, severe surveillance programs should perform to inhibit from their bacterial and fungal contamination.
One-Month Mortality of Acute Cerebral Infarctions and its Predictive Factors in African Low-Income Country: Case of Ouagadougou in Burkina Faso

Lompo Djingri Labodi1*, Cissé Kadari3, Diallo Ousséini2, Kouanda Boukari1, Napon Christian2 and Kaboré B Jean2 1CHU de Tingandogo, Training and Research Unit of Health Sciences, Ouaga I University, Pr Joseph Ki-Zerbo, Burkina Faso 2CHU Yalgado Ouedraogo of Ouagadougou, Health Sciences Training and Research Unit, Ouaga I University, Pr Joseph Ki-Zerbo, Burkina Faso 3Institut of Research in Health Sciences Ouagadougou, Department of Medical Biology and Public Health, Burkina Faso