Miracle-dz/UniFAR-FTUs huggingface dataset:
How Well Does the Mechanistic Water Quality Model CE‐QUAL‐W2 Represent Biogeochemical Responses to Climatic and Hydrologic Forcing?

Mechanistic water quality models are applied globally for water quality management in rivers and lakes. However, it is unclear how well these models represent the response of lakes to changes in climate and hydrologic conditions. To address this question, we conducted a series of climate and hydrologic sensitivity analyses using a parameterized water quality model, CE‐QUAL‐W2, for the Spokane River and Lake Spokane system. Two experimental tests with climate and flow forcing showed that the model predictions were rather insensitive to climatic‐driven hydrologic changes and a wide range of hydrologic conditions (1st to 99th percentile flows) for two different wastewater treatment plant discharge scenarios. The model realistically represented some aspects of Lake Spokane's observed responses to climatic and hydrologic variability, for example, the water residence time and some water quality trends. However, the model overestimated the reservoir total phosphorus (TPR) concentration by ~37% and the chlorophyll a (Chl a) concentration by ~31% and underestimated the minimum volume‐weighted hypolimnetic dissolved oxygen (DOMIN) concentration by ~26% for a wide range of flows compared to the observed data. In contrast to the model's water quality insensitivity, the modeled temperature was more sensitive to flow than was actually observed in Lake Spokane. This study provides guidance for improving the response of one of the most important mechanistic water quality models to climatic and hydrologic forcing and should help modelers and decision‐makers to develop a rigorous assessment of climate and flow sensitivity to improve the margin of safety when setting total maximum daily load targets.
A systematic review of quality of life and weight gain-related issues in patients treated for severe and persistent mental disorders: focus on aripiprazole

: Aripiprazole is a relatively novel second-generation antipsychotic belonging to the chemical class of benzisoxazole derivatives and is characterized by a unique pharmacological proﬁ le which suggests that the drug acts as a dopamine-serotonin system stabilizer. Whereas all previously available antipsychotics are antagonists at D 2 receptors, aripiprazole is the only available partial agonist at these receptors. Thus, it has been suggested that aripiprazole could be associated with a relatively neutral impact on bodyweight, possibly reducing risks of a detrimental impact on the quality of life that often complicates management for a large number of patients diagnosed with severe and persistent mental disorders (SPMDs) treated chronically with antipsychotic medications. However, data from short- and long-term reviewed studies indicate that the prevalence rate of clinically relevant weight gain during therapy with this drug is similar to that occurring during treatments with other antipsychotic agents, either typical or atypical. Moreover, information on the impact of aripiprazole therapy on the quality of life of patients diagnosed with SPMDs is scarce and characterized by conﬂ icting results. Given these results, further, large, well-designed studies are needed before conﬁ rming potential advantages of aripiprazole over ﬁ rst-generation antipsychotics and other SGAs.
Analysis of bio-accumulation of heavy metals in seaweeds ulva rigida and halimeda opuntia in validation of their safety for use in aquaculture feeds in Kenya

With capture fisheries output being threatened by overfishing and dwindling stocks, a long term vision for the supply of fish to the worlds growing population is aquaculture. However, the issue of fish feeds remains one of the challenges facing the aquaculture sector where the sources for most of the ingredients used for fish feed formulation are the same as those used for human consumption. Hence, a strategic focus for aquaculture must be to derive new sources, primarily taken from outside the human food chain, and to derive them mainly from primary producers for example marine algae (seaweeds). However, the use of seaweeds as animal feed is, among others, determined by their heavy metal status. U. rigida and H. opuntia are some of the seaweed species primarily used in artisanal fishery at the south coast of Kenya as fishing baits and have the potential for use as supplement ingredients in the formulation of fish feed for the widely farmed Nile tilapia. For purposes of determining their safety for use in fish feeds, a study was carried out to determine the concentration levels of Arsenic, Cadmium, Lead and Mercury. The heavy metals were investigated with respect to seasonal and site variations. Seaweed sample analysis was done following Atomic Absorption Spectroscopy. The values obtained were compared to the World health Organization (WHO) recommended levels for heavy metals in food and feed supplements. The concentration levels were significantly different (p<0.05) in the two seaweed species, varied with seasons and sites and compared variably with the WHO recommended levels.
Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury

Neuronal damage resulting from traumatic brain injury (TBI) causes disruption of neuronal projections and neurotransmission that contribute to behavioral deficits. Cellular generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an early event following TBI. ROS often damage DNA, lipids, proteins, and carbohydrates while RNS attack proteins. The products of lipid peroxidation 4-hydroxynonenal (4-HNE) and protein nitration 3-nitrotyrosine (3-NT) are often used as indicators of oxidative and nitrosative damages, respectively. Increasing evidence has shown that striatum is vulnerable to damage from TBI with a disturbed dopamine neurotransmission. TBI results in neurodegeneration, oxidative stress, neuroinflammation, neuronal apoptosis, and autophagy in the striatum and contribute to motor or behavioral deficits. Pomalidomide (Pom) is a Food and Drug Administration (FDA)-approved immunomodulatory drug clinically used in treating multiple myeloma. We previously showed that Pom reduces neuroinflammation and neuronal death induced by TBI in rat cerebral cortex. Here, we further compared the effects of Pom in cortex and striatum focusing on neurodegeneration, oxidative and nitrosative damages, as well as neuroinflammation following TBI. Sprague–Dawley rats subjected to a controlled cortical impact were used as the animal model of TBI. Systemic administration of Pom (0.5 mg/kg, intravenous [i.v.]) at 5 h post-injury alleviated motor behavioral deficits, contusion volume at 24 h after TBI. Pom alleviated TBI-induced neurodegeneration stained by Fluoro-Jade C in both cortex and striatum. Notably, Pom treatment reduces oxidative and nitrosative damages in cortex and striatum and is more efficacious in striatum (93% reduction in 4-HNE-positive and 84% reduction in 3-NT-positive neurons) than in cerebral cortex (42% reduction in 4-HNE-positive and 55% reduction in 3-NT-positive neurons). In addition, Pom attenuated microgliosis, astrogliosis, and elevations of proinflammatory cytokines in cortical and striatal tissue. We conclude that Pom may contribute to improved motor behavioral outcomes after TBI through targeting oxidative/nitrosative damages and neuroinflammation.
Mortality in women with a history of incarceration in Norway: a 20-year national cohort study

Abstract Background Women carry a substantial burden of psychiatric, somatic and lifestyle-related morbidity in the prison context. By describing causes of death and estimating the risk and burden of mortality compared with the general population, this study investigates how mortality operates in this highly marginalized and under-researched population. Methods In this registry-based study of all women incarcerated in Norwegian prisons from 2000 to 2019 (N = 11 313), we calculated crude mortality rates, years of lost life and, by using mortality in age-matched women from the general population as a reference, age-standardized mortality ratios and years of lost life rates. Results Over a mean follow-up time of 10.7 years, at a median age of 50 years, 9% of the population had died (n = 1005). Most deaths (80%) were premature deaths from an avoidable cause. Drug-induced causes and deaths from major non-communicable diseases (NCDs) were most frequent (both 32%). Compared with women in the general population, women with a history of incarceration were more likely to die from any cause. Trends in annual age-standardized years of lost life rates suggest that the mortality burden associated with major NCDs has gradually replaced drug-induced causes. Conclusions Women with a history of incarceration die at a greater rate than their peers and largely from avoidable causes. The profile of causes contributing to the substantial burden of mortality placed on this population has changed over time and has important implications for future efforts to reduce morbidity and the risk of premature death following release from prison.
Structure–Function Interactions in the Hippocampus and Prefrontal Cortex Are Associated with Episodic Memory in Healthy Aging

Aging comes with declines in episodic memory. Memory decline is accompanied by structural and functional alterations within key brain regions, including the hippocampus and lateral prefrontal cortex, as well as their affiliated default and frontoparietal control networks. Most studies have examined how structural or functional differences relate to memory independently. Here we implemented a multimodal, multivariate approach to investigate how interactions between individual differences in structural integrity and functional connectivity relate to episodic memory performance in healthy aging. In a sample of younger (N = 111; mean age, 22.11 years) and older (N = 78; mean age, 67.29 years) adults, we analyzed structural MRI and multiecho resting-state fMRI data. Participants completed measures of list recall (free recall of words from a list), associative memory (cued recall of paired words), and source memory (cued recall of the trial type, or the sensory modality in which a word was presented). The findings revealed that greater structural integrity of the posterior hippocampus and middle frontal gyrus were linked with a pattern of increased within-network connectivity, which together were related to better associative and source memory in older adulthood. Critically, older adults displayed better memory performance in the context of decreased hippocampal volumes when structural differences were accompanied by functional reorganization. This functional reorganization was characterized by a pruning of connections between the hippocampus and the limbic and frontoparietal control networks. Our work provides insight into the neural mechanisms that underlie age-related compensation, revealing that the functional architecture associated with better memory performance in healthy aging is tied to the structural integrity of the hippocampus and prefrontal cortex.
Changes in breast cancer grade from biopsy to excision following surgery or primary chemotherapy

Summary Objective To compare histological grade (G) of breast cancer and its components (scores for tubule formation - T, nuclear pleomorphism - P and mitotic counts - M) in core needle biopsies (CNBs) and surgical excision specimens (EXC) in patients treated with primary surgery (CHIR) or primary chemotherapy (PST). Methods Grade of matched pairs of carcinomas in CNB and EXC was assessed according to the Nottingham grading system. Results PST cases tended to have higher pretreatment G. Concordance rates in the CHIR (n = 760) and PST (n = 148) groups for T, P, M and G were 79%, 70%, 75%, 71% and 77%, 70%, 50%, 62%, respectively; differences in concordance rates were significant in M (p < 0.0001) and G (p = 0.024). For discordant cases in the CHIR group, CNBs tended to overestimate T and underestimate P, M and G, whereas in the PST group, the same trends were identified for T and P, but there was a significant tendency for M and G to be lower in EXC specimens. Conclusions The reversal of M and G underestimation in CNB to “overestimation” in the PST group can only be explained with the effect of mitosis reduction following chemotherapy. Whether the posttreatment decrease in G reflects any prognostic value remains to be elucidated.
REVISION OF LOBELIA SECT. GALEATELLA (CAMPANULACEAE: LOBELIOIDEAE)

Lobelia sect. Galeatella is a group of pachycaul treelets distinguished by a solitary pliestesial hapaxanthic shoot from a suckering rootstock; a dense apical rosette of sessile coriaceous leaves leaving a helical pattern of raised corky cicatrices on the unbranched stem; a branched or unbranched terminal short-pedunculate bracteate raceme of large ornithophilous flowers on ebracteolate pedicels; calyx lobes caducous from the young fruit; non-blue corolla with linear monomorphic lobes, the dorsal pair spreading or recurved horizontally, about as long as the stout tube to 3 times longer, the ventral connate for 2/3 their length or more, forming a deflexed inrolled trifid lip shorter than the dorsal pair; staminal column exserted, all five anthers with apical tufts of white trichomes; apically loculicidal capsule enshrouded at maturity by an irregular network of sclerenchymatous bundles; and winged oblong compressed seeds with a faintly striate testa. The section is endemic to the Hawaiian Islands, with two species each on Kaua'i (L. villosa and L. wahiawa, sp. nov.) and O'ahu (L. gaudichaudii and L. koolauensis, comb, et stat. nov.), and a single species (L. gloria-montis) on Maui and Moloka'i, divided into two subspecies: subsp. gloria-montis (West Maui and Moloka'i) and subsp. longibracteata, stat. nov. (West Maui and East Maui). The two species on Kaua'i hybridize, producing L. xkauaiensis, stat. nov.
Integrating single‐cell and spatial transcriptomes reveals COL4A1/2 facilitates the spatial organisation of stromal cells differentiation in breast phyllodes tumours

Abstract Background Breast phyllodes tumours (PTs) are a unique type of fibroepithelial neoplasms with metastatic potential and recurrence tendency. However, the precise nature of heterogeneity in breast PTs remains poorly understood. This study aimed to elucidate the cell subpopulations composition and spatial structure and investigate diagnostic markers in the pathogenesis of PTs. Methods We applied single‐cell RNA sequencing and spatial transcriptomes on tumours and adjacent normal tissues for integration analysis. Immunofluorescence experiments were conducted to verify the tissue distribution of cells. Tumour cells from patients with PTs were cultured to validate the function of genes. To validate the heterogeneity, the epithelial and stromal components of tumour tissues were separated using laser capture microdissection, and microproteomics data were obtained using data‐independent acquisition mass spectrometry. The diagnostic value of genes was assessed using immunohistochemistry staining. Results Tumour stromal cells harboured seven subpopulations. Among them, a population of widely distributed cancer‐associated fibroblast‐like stroma cells exhibited strong communications with epithelial progenitors which underwent a mesenchymal transition. We identified two stromal subpopulations sharing epithelial progenitors and mesenchymal markers. They were inferred to further differentiate into transcriptionally active stromal subpopulations continuously expressing COL4A1/2. The binding of COL4A1/2 with ITGA1/B1 facilitated a growth pattern from the stroma towards the surrounding glands. Furthermore, we found consistent transcriptional changes between intratumoural heterogeneity and inter‐patient heterogeneity by performing microproteomics studies on 30 samples from 11 PTs. The immunohistochemical assessment of 97 independent cohorts identified that COL4A1/2 and CSRP1 could aid in accurate diagnosis and grading. Conclusions Our study demonstrates that COL4A1/2 shapes the spatial structure of stromal cell differentiation and has important clinical implications for accurate diagnosis of breast PTs.
Changing Furrow Irrigation to Increase Efficiency and Feasibility Study of Reusing Surface Runoff

To improve irrigation techniques and the utilization of available water resources in Iran, a first steps re evaluation of traditional irrigation methods. To assess the efficiency of furrow irrigation, a 4-ha plot (87 furrows) cultivated with sugarcane was evaluated in Khuzestan Province. The quantities of inflow, outflow runoff, soil moisture before irrigation, depth of root development and depth of water infiltration were measured and thus the values of water use efficiency, uniformity coefficient, and distribution uniformity were determined for the selected plot. Using Geographical Information System, in ArcView, the irrigation efficiency of its levels were analyzed using two furrow irrigation methods: open and closed-end. The results showed that the irrigation efficiency, uniformity coefficient and distribution uniformity for the open-end than the closed-end method. The prevention of deep infiltration losses (approximately 30% lower than for closed-end) and allowing outflow of end runoff, and depending on water quality, the riffle can be considered ideal for irrigating other surfaces.
Single-step genomic predictions for crossbred Holstein and Jersey cattle in the US

: In the dairy cattle sector, the number of crossbred genotypes increased in the last years, and therefore, the need for accurate genomic evaluations for crossbred animals has also increased. Thus, this study aimed to investigate the feasibility of including crossbred genotypes in multi-breed, single-step GBLUP (ssGBLUP) evaluations. The Council of Dairy Cattle Breeding provided more than 47 million lactation records registered between 2000 and 2021 in purebred Holstein and Jersey and their crosses. A total of 27 million animals were included in the analysis, of which 1.4 million were genotyped. Milk, fat, and protein yields were analyzed in a 3-trait repeatability model using BLUP or ssGBLUP. The 2 models were validated using prediction bias and accuracy computed for genotyped cows with no records in the truncated data set and at least one lactation in the complete data set. Bias and accuracy were better in the genomic model than in the pedigree-based one, with accuracies for crossbred cows higher than those of purebreds, except for fat yield in Holstein. Our study shows that genotypes for
MoAti1 mediates mitophagy by facilitating recruitment of MoAtg8 to promote invasive growth in Magnaporthe oryzae

Abstract Mitophagy is a selective autophagy for the degradation of damaged or excessive mitochondria to maintain intracellular homeostasis. In Magnaporthe oryzae, a filamentous ascomycetous fungus that causes rice blast, the most devastating disease of rice, mitophagy occurs in the invasive hyphae to promote infection. To date, only a few proteins are known to participate in mitophagy and the mechanisms of mitophagy are largely unknown in pathogenic fungi. Here, by a yeast two‐hybrid screen with the core autophagy‐related protein MoAtg8 as a bait, we obtained a MoAtg8 interactor MoAti1 (MoAtg8‐interacting protein 1). Fluorescent observations and protease digestion analyses revealed that MoAti1 is primarily localized to the peripheral mitochondrial outer membrane and is responsible for recruiting MoAtg8 to mitochondria under mitophagy induction conditions. MoAti1 is specifically required for mitophagy, but not for macroautophagy and pexophagy. Infection assays suggested that MoAti1 is required for mitophagy in invasive hyphae during pathogenesis. Notably, no homologues of MoAti1 were found in rice and human protein databases, indicating that MoAti1 may be used as a potential target to control rice blast. By the host‐induced gene silencing (HIGS) strategy, transgenic rice plants targeted to silencing MoATI1 showed enhanced resistance against M. oryzae with unchanged agronomic traits. Our results suggest that MoATI1 is required for mitophagy and pathogenicity in M. oryzae and can be used as a target for reducing rice blast.
Fingerprint of tropical climate variability and sea level in sediments of the Cariaco Basin during the last glacial period

High‐resolution palaeorecords of climate are critical to improving current understanding of climate variability, its sensitivity and impact on the environment in the past and in the future. Sediments from the Cariaco Basin off the coast of Venezuela have proven to be sensitive recorders of tropical palaeoclimate variability down to an annual scale. However, the fingerprint of climate and sea level in the sediments of the last glacial period is still not completely understood. In this study, lamination analysis of sediments from the Cariaco Basin is extended to the last glacial period. Detailed sedimentological and geochemical analysis (laser ablation–inductively coupled plasma–mass spectrometry) reveals couplets of light‐coloured, terrigenous‐rich and dark‐coloured, biogenic opal‐rich laminae, which are interpreted to reflect the seasonal migration of the Intertropical Convergence Zone. In addition, a previously undescribed, nearly pure terrigenous lamina type is observed, which is referred to hereafter as a ‘C‐layer’. The C‐layers in the sedimentary sequence are interpreted as flood layers that originate from local rivers. The occurrence of these C‐layers is investigated for two core locations in the Cariaco Basin over the last 110 kyr by continuous X‐ray fluorescence scanning. Dansgaard–Oeschger oscillations are most clearly traced by proxies reflecting productivity and marine organic matter content of the sediment. In contrast, the abundance of terrigenous material differs at times between the two sites. On an interglacial to glacial timescale, the ability to record events causing C‐layers is likely to be influenced by changes in sea level and source proximity. On a millennial scale, both sediment cores contain more C‐layers during warmer interstadials compared with colder stadials during Marine Isotope Stage 3. This finding implies that interstadials were not only wetter than stadials, but probably also characterized by increased rainfall variability, leading to an enhanced frequency of flooding events in the hinterland of the Cariaco Basin.