Miracle-dz/UniFAR-FTUs huggingface dataset:
Use and safety of KAATSU training: Results of a national survey in 2016

Introduction KAATSU training is a novel method for muscle training, originally developed by Sato (2005). Unlike the hemostasis achieved by the use of a tourniquet which completely stops both the artery and vein, the KAATSU training is performed by moderate blood flow restriction using a specially designed belt; it is carried out while pooling the blood in the upper or the lower limb. Previous studies have shown that KAATSU training with various types of load resistances (such as weight, machine, and elastic band) is effective in rehabilitation medicine and health enhancement (Abe et al., 2006; Nakajima et al., 2011; Yasuda et al., 2014; Yasuda et al., 2015). At present, various subjects such as athletes, healthy persons, and elderly persons have performed KAATSU training, and KAATSU training is being widely used all over the world. Since the Japan KAATSU Training Society was established in 2004, academic research on KAATSU training has widely increased progressively in Japan. In 2006, Nakajima and colleagues examined the use and side effects of KAATSU training. They sent out questionnaires by postal mail, as a national survey, and obtained results from KAATSU leaders or instructors from a total of 105 facilities where KAATSU training has been adopted (Nakajima et al., 2006). Their study concluded that despite the fact that KAATSU training has been widely practiced at various facilities, it does not induce side effects such as serious complications. According to the search engine results in PubMed, the number of academic research studies regarding KAATSU training has increased dramatically from 2006 to 2016. In addition, since prevention and treatment effects of KAATSU training for diseases can be expected, case reports on the use of KAATSU in the clinical setting for patients with various diseases have also been reported (Hughes et al., 2017). As a result, there is a high possibility that the Use and safety of KAATSU training: Results of a national survey in 2016
Contemporary researches and issues related to the Deccan volcanism

In the past few decades, late Cretaceous Deccan volcanism witnessed extensive researches, focused on nature, variety and genesis of magma, emplacement span [entail Cretaceous /Palaeogene (K/Pg) transition] and attendant faunal crisis; however several issues remain to be addressed. In this gamut, researches in the past five years have been reviewed, encompassing petrochemical, Nd-Sr-Pb isotopic, and geochronology studies to comprehend origin, age and duration of volcanism and attendant K/Pg transition events. Low/high TiO 2 tholeiites of Deccan Traps and associated rocks from a rifted basin revealed existence of varied mantle sources for synchronously formed tholeiitic and alkaline magma involved sub-continental lithospheric mantle. Moreover, later magma type ascended with faster rate through the lithosphere and subsequently led to rapid gaseous release, accounted for the Cretaceous/Palaeogene boundary (KPB) mass extinction. Flow-by-flow palaeomagnetic measurements for the Mandla basalt revealed multiple magnetic polarity events: implying for C29n-C28rC28n magnetostratigraphy.
Signing Auditors’ Foreign Experience and Debt Financing Costs: Evidence for Sustainability of Chinese Listed Companies

This study investigates whether signing auditors with foreign experience influence debt financing costs. Using a sample of Chinese listed firms for the period of 2001–2016, this study hand-collects the information of signing auditors’ foreign experience and empirically examines the relationship between signing auditors’ foreign experience and debt financing costs. The empirical results show that signing auditors’ foreign experience is significantly and negatively correlated with debt financing costs, suggesting that signing auditors’ foreign experience improves audit quality, reduces information risk and thereby lowers the cost of debt financing. Further analyses show that the negative effect of signing auditors’ foreign experience on the cost of debt financing is more pronounced in audit firms without industry expertise, suggesting that audit firm industry expertise mitigates the negative relationship between signing auditors’ foreign experience and debt financing costs. These results imply that signing auditors who have foreign experience could serve a significant role in debt financing, which would strengthen firms’ sustainability.
Are clinical and functional results of MIPPO and IMN for treatment of extraarticular distal tibia fractures similar

Aim: Controversy still exists on whether intramedullary nailing (IMN) or minimal invasive percutaneous osteosynthesis (MIPPO) is better for treatment of extra-articular distal tibia fractures. In this study, our aim was to retrospectively compare the clinical and functional results of patients with distal tibia fractures that were treated f by plate or nail. Materials and Methods: This study included 46 patients with a mean age of 40,3 (range, 18-63 years). All had closed extra-articular distal tibia fractures within 4 to 10 cm away from the tibial plafond and two senior trauma surgeons operated them with either MIPPO (n=27) or IMN (n=19) technique. Patients were followed up until full bony union occurred and also hospitalization time, union time, malunion criteria; complication rates and AOFAs were evaluated. Results: Mean follow up was 12.5 (range, 10-16 months) months and no major vessel injury or deep infection was observed in either group. Full bony union time was similar in two groups (15±12.7 weeks in MIPPO and 16±11.3 weeks in IMN group; p=0.062). Also, there was not statistically significant difference in MIPPO and IMN groups for nonunion rates [3 (11%) vs. 1 (5.3%)] and malunion rates 3 (11.1%) vs. 2 (10.5%)] (p>0.05). However, secondary surgical intervention was performed in two patients (7.4%) of MIPPO group for severe wound dehiscence (p=0.04). Conclusion: The two surgical techniques are equivocal for nonunion or malunion rates. However, wound problems may be seen after MIPPO technique and surgeon must be cautious for applying plate when patient has apparent wound problem.
Isolation and in vitro Characterization of Anti-Salmonella Enteritidis Probiotic Potential of Indigenous Lactobacilli from Poultry

Received: Revised: Accepted: Published online: November 26, 2018 December 31, 2018 January 01, 2019 January 28, 2019 Aim of the present study was to isolate, identify and characterize new indigenous Lactobacillus strains with probiotic potential against Salmonella Enteritidis. From 84 isolated lactobacilli of indigenous poultry origin, 15 isolates were pre-selected for in vitro characterization on the basis of their activity (6.33±0.57-20.33±1.15 mm) against S. Enteritidis by well diffusion assay. All pre-selected isolates had variable tolerance to acidic pH (2, 3 and 4). All isolates also showed growth in MRS broth supplemented with 0.3, 1 and 1.8% bile salts. Isolates had varying degree of auto-aggregation (27.05±0.72 65.87±3.12%) and co-aggregation with S. Enteritidis (6.33±0.11 55.70±1.32%) within 2 hours. Safety profile of lactobacilli indicated that IKP23, IKP 111 and IKP 333 had no acquired antibiotic resistance. IKP 23, IKP 111 and IKP 333 were selected as potential probiotics on the basis of probiotic prerequisites and identified as L. fermentum, L. fermentum and L. salivarius, respectively by sequencing their partial 16S rRNA gene or 16S-23S intergenic spacer region. IKP 23, IKP 111 and IKP 333 inhibited S. Enteritidis (81, 99.3 and 93%, respectively) in co-culture experiments. This study insinuate that IKP 23, IKP 111 and IKP 333 have favourable probiotic potential and may be used for in vivo studies for the development of probiotics against S. Enteritidis. ©2019 PVJ. All rights reserved
Association between depression and cardiorespiratory fitness in general population and patients with heart disease

Depression symptom severity and cardiorespiratory fitness (CRF) are both predictors of mortality and disability in healthy individuals and patients with heart disease. However, the relationship between the two is unclear. We conducted two systematic reviews and meta-analyses in otherwise healthy individuals and patients with heart disease, respectively, in order to assess the relationship between depression symptom severity and CRF. The first study (Papasavvas et al., 2016b) included 16 studies (4039 participants) and revealed a negative correlation between depression symptom severity and CRF [correlation coefficient (CC 0.16, 95 % CI -0.21 to -0.10)] that appeared stronger in male (CC 0.22, 95 % CI -0.26 to -0.18) than in female individuals (CC -0.12, 95 % CI -0.19 to -0.05; p = 0.01). The second study (Papasavvas et al., 2017) included 59 studies (25733 participants) and also revealed a negative correlation between depression symptom severity and CRF (CC − 0.15; 95% CI, − 0.17 to − 0.12) that was independent to sex. Within-study level moderator analysis was not possible because raw data were not available for every study. I also assessed the effects of potential moderators of the correlation between depression symptom severity and CRF in 1489 patients with heart disease using linear and logistic regression analysis. Sex (p = 0.007) and BMI (p < 0.001) moderated the correlation: Lower BMI enhanced the correlation, while higher BMI attenuated the correlation in male patients and rendered it statistically not significant in female patients (Papasavvas 2018 unpublished). We also translated the Cardiac Depression Scale to Arabic and validated it in a representative sample of 260 Arab patients with heart disease (Papasavvas et al., 2016a), in order to assess depression symptom severity in the following study. The subsequent quasi-experimental study aimed to assess whether depression reduces CRF in patients with heart disease but this was eventually not feasible. The above findings have clinical and prognostic implications and should stimulate further research on the effects of improving depression symptom severity on CRF and vice versa. Potential causative relationships between depression symptom severity and CRF should also be investigated.
Correlation between strength of T-cell response against HPV16 and survival after vaccination with HPV16 long peptides in combination with chemotherapy for late-stage cervical cancer.

140Background: Therapeutic vaccination with HPV type 16 synthetic long peptides (HPV16-SLP) results in T cell–mediated regression of HPV16-induced premalignant lesions but fails to install effective immunity in patients with advanced HPV16-positive cervical cancer. We showed that HPV16-SLP vaccination in mice and in patients with advanced cervical cancer patients fosters robust HPV16-specific T cell responses, when combined with chemotherapy. In this study we noted that a single dose of vaccine 2 weeks into the 2nd cycle of chemotherapy was optimal, because at this time the immunosuppressive myeloid cells were down. Methods: We now completed a chemo-immunotherapy study in a larger number of patients with late stage HPV16+ cervical cancer. Three HPV16-SLP vaccine doses were given 2 weeks after the second, third, and fourth cycles of standard chemotherapy. Cohorts of 12 patients each were vaccinated with each of 4 dose levels (20, 40, 100, and 300 µg/ per peptide) of 13 overlapping HPV16 synthetic long pept.
Helping Students Develop Intercultural Intelligence In Tertiary Education

Many students never develop good intercultural competencies during their years at college or university. These students are often unaware of how important cultural attitudes, beliefs, and behaviors are in their daily and academic lives. Students are also unaware of their own cultural boundaries that may be impacting their communication and engagement with others. Assignments that teach intercultural competencies can help students in a variety of ways: to gain confidence in their own cultural identity and acquire a set of skills to communicate and lead in a global world. In this paper, the researcher discusses some effective activities that can be used to teach students intercultural competencies and increase students' intercultural intelligence. Activities are based on experiential and blended learning approaches and integrate technology tools to engage learners. These activities are based on Knowledge Workx intercultural intelligence training that introduces three key theories of culture: Hofstede's cultural dimensions, World View theory, and Knowledge Workx of 12 Dimensions. These theories follow the layers of culture found in an iceberg metaphor that includes the top of the iceberg and observable culture, next is attitudes, the third layer is norms and values, and finally the most hidden layer is one's beliefs. Based on these theories, three blended and experiential projects were developed to include cultural object presentations, a research project on current intercultural conflict, and a cross cultural communication research and application of cultural maps. Three psychometric tests were also used to increase intercultural awareness: culture learner/critic, worldview, and 12 Dimensions tests.
Real-World Evidence and Randomized Studies in the Precision Oncology Era: The Right Balance.

Randomized clinical trials (RCTs) are the gold standard for rational therapeutics in evidencebased medicine. Although variable, the cost of conducting an RCT can be as high as $1 billion, putting into question their feasibility for every health care intervention. Also, the broader application of RCT outcomes has been subject to scrutiny, considering the inherent selection bias. Less than 5% of adult patients with cancer participate in clinical trials, and thosewhodo are younger, healthier, and less diverse than their real-world counterparts. Today, RCTs remain the gold standard despite changing practice patterns; however, becauseof their limitations, coupledwithunmethealth careneeds, a reassessmentofwhether this traditional approach should be required for low-risk interventions, particularly in cancer, is warranted.
Adsorption Properties of Magnetic Magnetite Nanoparticle for Coexistent Cr(VI) and Cu(II) in Mixed Solution

The adsorption properties of coexistent Cr(VI) and Cu(II) in mixed solution on magnetic magnetite (Fe3O4) nanoparticle were studied in batch experiments. The influences of various factors, such as pH, adsorbent dose, temperature, initial concentration of metal ions, and coexisting ions in water were investigated. At the same time, the adsorption kinetics and adsorption isotherms were studied. The mechanism of adsorption for Cr(VI) and Cu(II) was investigated through the study of surface properties of Fe3O4, the presence of ions, and the influence of pH and zeta potential. The results indicate that pH has an influence on adsorption for Cr(VI) and Cu(II), and the optimal pH value for Cr(VI) and Cu(II) adsorption is 4.0. The adsorption efficiency increased with the increase of the adsorbent dose. Temperature under experimental design had no obvious effect. With 2.0 g/dm3 Fe3O4, the maximum adsorption capacity for Cr(VI) and Cu(II) reached 8.67 mg/g and 18.61 mg/g in mixed solution of 80 mg/dm3 Cr(VI) and Cu(II), respectively. Phosphorus had some influence on the adsorption for Cr(VI), and other coexisting anions and cations had no influence on the adsorption for Cr(VI) and Cu(II). The adsorption data for Cr(VI) and Cu(II) were nicely fit to the Langmuir adsorption equation and the pseudo-second-order model. As a multifunctional material, nano-Fe3O4 exhibited good adsorption performance for coexistent Cr(VI) and Cu(II) and could easily be separated and recovered under magnetic field.
CIC‐associated round cell sarcoma of the small bowel

Small round cell sarcoma (SRCS) is considered a highly aggressive soft tissue tumour. The World Health Organization (WHO) has recognized a distinct subtype in view of the recently discovered CIC fusion gene. It has shown to have distinct pathophysiology and prognosis unlike Ewing sarcoma (ES) and rhabdomyosarcoma. However, due to its rarity, no standardized treatment has been concluded. We reported a case of intestinal obstruction caused by small bowel associated associated, laparotomy and small bowel resection was performed with good recovery and 1 year free disease survival. The gold standard of diagnosis with molecular confirmation is utmostly important in order to learn more about the natural history of this subtype thus formulating the best management plan.
ENVIRONMENTAL RISKS ASSESSMENT FOR SOILS AND PLANTS IRRIGATED FROM El-MARIOUTEYA AND EL-RAHAWY DRAIN

The objective of this study was to evaluate the environmental risks of water, soils, and plants from the El-Mariouteya Canal and El-Rahawy drain. To achieve this aim, pH and electrical conductivity EC in water and soils, as well as sodium adsorption ratio (SAR) in water; some micro elements and heavy metals were estimated in water; soils and plants. In addition to calculation of contamination factor (CF), degree of contamination (Cd), modified degree of contamination (mCd); pollution load index (PLI) and bio-accumulation factor of elements in plants. The obtained results indicated that the values of pH and (SAR) in the water were different from season to another season. (EC) values were very high and unsuitable for irrigation in summer season; while they were suitable for irrigation in winter season according to FAO. Regard to soil pH values tend to be normal, slightly and moderately alkaline and (EC) was ranged between non-saline to highly saline soils. However, boron, cadmium, cobalt, chromium, nickel and lead were within the safe limits. The total content of cadmium exceeded the safe limits in both seasons, but other elements were within the safe limits. The lowest concentration of iron, boron, cobalt and chromium was found in Wheat yield. Manganese and nickel were found in the fruits of Eggplant, zinc and copper were found in Cabbage. While the highest concentrations of iron, manganese, copper, cobalt, chromium and nickel were found in Okra. Zinc was found in Spinach and boron was found in Watercress. BCF indicates that the most plants have more than 1 and showed high concentrations of heavy metals. The values of (CF) were low for both zinc, boron and lead for all sites and medium for copper and cobalt at all sites and low to medium with both iron, manganese, chromium and nickel indicating that this contamination is related to human activities. Modified contamination degree (mCd) is moderate to high in some sites. The (PLI) is generally high (> 1) in all sites; exception one site. The (PLI) was low (<1) in some sites in winter season.
Pattern of Adverse Drug Reaction to Antiepileptic Drugs at a Tertiary Hospital in North-Central Nigeria: A Prospective Observational Study

Background: Epilepsy is a common neurologic condition affecting 0.5-1% of the population. Adverse drug reactions (ADRs) are a major health problem to the individual as well as for the society. There is insufficient awareness and initiating antiepileptic drugs. Electroencephalogram, complete blood count, liver function test, and serum electrolytes, urea and creatinine were also done. Patients and their caregivers were counseled on the adverse drug reactions of the drugs being initiated and asked to return to the clinic immediately they observe any of the reactions. Patients were assessed for adverse reactions on each visit. Further laboratory evaluations were done for those with adverse reactions if necessary. Causal relationship between adverse drug reaction and treatment was assessed with the Naranjo Algorithm. Results: Four hundred and nine patients were initiated on antiepileptic drugs within the study period. Two hundred and twenty-one (54.0%) were on monotherapy while 188 (46.0%) were on polytherapy. The most frequently prescribed drugs were carbamazepine (34.7%), carbamazepine+valproic acid (33.7%) and valproic acid (15.2%). A total of 113 (27.6%) patients had 193 different adverse drug reactions. The commonest adverse drug reactions were sleep disorders (33.7%), skin rash (10.9%), dizziness (7.8%), fatigue (10.7%) and nausea (6.75%). Those on polytherapy were significantly more likely to have adverse drug reactions compared to those on monotherapy (Relative Risk = 1.65, 95% confidence interval 1.20-2.27; P = 0.002). Conclusion: Adverse drug reactions are common in children on antiepileptic drugs. Pharmacovigilance is very important in children on antiepileptic drugs so that adverse drug reactions can be identified early and managed appropriately.
School staff members’ and parents’ experiences of the inclusion of deaf children in Malaysian mainstream schools

ABSTRACT Educational services for deaf children are relatively well developed in Malaysia, especially in urban areas, and include special schools and separate classrooms in mainstream schools. Increasing numbers of deaf children have cochlear implants and are educated in mainstream classrooms. A study was conducted in three primary schools, involving interviews with seven parents, five school leaders, five mainstream teachers, five specialist teachers and three teaching assistants in Selangor State, the most developed in Malaysia, and answered the following research question: ‘What are stakeholders’ experiences of the inclusion of deaf children in mainstream schools? ’. Findings revealed that the small number of qualified teachers of deaf children teach through the medium of signed communication, yet parents are encouraged by health professionals to teach their children to speak, with amplification. Although school leaders and mainstream teachers are not trained to support deaf children and did not have the necessary expertise to check and maintain hearings aids and cochlear implants, there was evidence of promising practice emerging in relation to positive attitudes and innovation within the rigid curriculum. We discuss some of the implications of this study for parents who are not able to make informed choices about their children's communication options and educational placements.
Nutritional quality of snacks for preschoolers recommended on the internet

Introduction: Concerns about proper nutrition in childhood have been highlighted by the media. This is accompanied by an ongoing increase in the number of Internet pages, including those on social networks, channeled toward providing health information. Objective: To analyze the nutritional quality of snack recipes presented on web pages, aimed at preschoolers and described as healthy. Methods: a cross-sectional study carried out in 2015. A search was made for Brazilian web pages aimed at the lay public, and that contained snacks for children between 2 and 6 years of age. The first 20 URLs located by the search engine were selected and 10% of the recipes were set apart. The snacks were checked for compliance with steps 6, 7, and 8 of the Food Guide. Subsequently, nutritional labels were made for the preparations that met the three pre-established steps. Results: 85% of the pages were sites, 5% were blogs, and the rest were identified as sites/blogs. It was found that all were readable/comprehensible and 40% provided author identification. Of the 35 preparations initially observed, 31.4% met all three steps for healthy eating. In the qualitative analysis, seven were considered hypocaloric; only one of the snacks came close to the proposed carbohydrate content; two had excess protein. In general, the recipes had low quantities of: lipids, calcium, iron, sodium, and fiber. Conclusions: less than half of the addresses consulted identified the author. In addition, the recipes were predominantly misleading, as most had inadequacies in macronutrient and micronutrient content.