Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Structures Reveal Synergistic Rescue of Δ508 CFTR by Trikafta Modulators

The predominant mutation causing cystic fibrosis, a deletion of phenylalanine 508 (Δ508) in the cystic fibrosis transmembrane conductance regulator (CFTR), leads to severe defects in CFTR biogenesis and function. The advanced therapy Trikafta combines the folding corrector tezacaftor (VX-661), the channel potentiator ivacaftor (VX-770), and the dual-function modulator elexacaftor (VX-445). However, it is unclear how elexacaftor exerts its effects, in part because the structure of Δ508 CFTR is unknown. Here, we present cryo–electron microscopy structures of Δ508 CFTR in the absence and presence of CFTR modulators. When used alone, elexacaftor partially rectified interdomain assembly defects in Δ508 CFTR, but when combined with a type I corrector, did so fully. These data illustrate how the different modulators in Trikafta synergistically rescue Δ508 CFTR structure and function. Description How three drugs restore function Cystic fibrosis is caused by defects in a chloride channel crucial for proper fluid balance and secretion. Deletion of a single amino acid, phenylalanine 508 (Δ508), is the most common mutation and leads to misfolding and degradation of the protein before it can reach cell surfaces. Fiedorczuk and Chen determined the structures of the Δ508 channel bound to three drugs that are given in combination therapy to correct folding and potentiate the channel. They uncovered a binding site for one of the drugs, a dual function corrector and potentiator, that was not previously known. The structures showed only a partial correction of folding when only one corrector was provided, but full correction was achieved when type I and III correctors were bound. —MAF Molecular structures reveal how three drugs rectify the effects of the most common CFTR mutant in cystic fibrosis.
Community Member and Health Care Provider Perspectives on Communication With Chinese American Patients With Cancer: A Qualitative Study

PURPOSE: Effective health care provider-patient discussions of cancer diagnoses and prognoses are essential to enhance health outcomes in oncology. Chinese Americans have been designated an underserved population in oncology by the National Institutes of Health. We explored the perspectives of Boston Chinese American community members and health care providers regarding communication preferences and decision making in oncology care. METHODS: In this inductive, qualitative study, we conducted virtual, semi-structured interviews with 21 health care providers with experience in caring for Chinese American patients with cancer and 25 older Boston Chinatown community members who self-identify as Chinese or Chinese American. Thematic analysis was performed. Results: Two major themes were identified. First, provider communication should incorporate a gentle but truthful approach, careful word choice, authority-led style, and professionalism. Second, the family plays a large role in medical and nonmedical settings, and a family-centered approach to communication should be used. Conclusion: Our study builds on and challenges current knowledge regarding oncologic communication with Chinese American patients. A focus on the improvement of provider-patient cancer communication for Chinese Americans will improve care quality and satisfaction among patients and clinicians alike and serve to decrease disparities in care.
Risk of Hepatitis B Virus (HBV) Reactivation in HBsAg-Negative, Anti-HBc-Negative Patients Receiving Rituximab for Autoimmune Diseases in HBV Endemic Areas

Background/Aims Rituximab is known to be associated with high hepatitis B virus (HBV) reactivation rate in patients with resolved HBV infection and hematologic malignancy. However, data regarding HBV reactivation (HBVr) in rheumatic patients receiving rituximab is limited. To assess the HBVr rate in hepatitis B surface antigen (HBsAg)-negative patients receiving rituximab for autoimmune diseases in a large real-world cohort. Methods From March 2006 to December 2019, 900 patients with negative HBsAg receiving at least one cycle of rituximab for autoimmune diseases in a tertiary medical center in Taiwan were retrospectively reviewed. Clinical outcome and factors associated with HBVr were analyzed. Results After a median follow-up period of 3.3 years, 21 patients developed HBVr, among whom 17 patients were positive for hepatitis B core antibody (anti-HBc) and four were negative. Thirteen patients had clinical hepatitis flare, while eight patients had HBsAg seroreversion without hepatitis. Old age, anti-HBc positivity, undetectable serum hepatitis B surface antibody level at rituximab initiation and a higher average rituximab dose were associated with a higher HBVr rate. There was no significant difference in the HBVr risk between rheumatoid arthritis and other autoimmune diseases. Among anti-HBc-negative patients, subjects without HBV vaccination at birth had an increased risk of HBVr (4/368, 1.1%) compared with those who received vaccination (0/126, 0%). Conclusions In HBV endemic areas where occult HBV is prevalent, anti-HBc-negative patients, may still be at risk for HBVr after rituximab exposure. HBVr may still be considered in HBsAg-negative patients developing abnormal liver function after rituximab exposure, even in patients with negative anti-HBc.
Effects of Combined Visible and Infrared Light Rhinophototherapy in Patients With Allergic Rhinitis

Background Intranasal phototherapy offers an alternative treatment method for patients with allergic rhinitis who cannot benefit from intranasal corticosteroids and oral antihistamines. Different wavelengths have been tried with promising results. Objective In this present study, we aimed to investigate the effects of visible light-infrared light phototherapy on clinical improvements together with its cytologic effects in patients with allergic rhinitis. Methods Patients with confirmed allergic rhinitis were given a 4-week course of intranasal phototherapy treatment. Weekly symptom questionnaires were applied to monitor clinical effects. Nasal lavage specimens were obtained before the start and at the completion of the 4-week therapy. Fluorescence-activated cell sorting analyses of CD16+, CD24+, and CD 45+ cells were performed. Statistical analyses are performed of weekly changes in symptoms and cell counts. Results CD45+CD16highCD24+ neutrophil count in nasal lavages decreased significantly whereas CD45+CD16dim/−CD24+ eosinophil counts significantly increased and CD45+ granulocyte counts remained unchanged. Symptom scores including nasal itching, nasal discharge, nasal obstruction, sneezing, eye itching, throat itching, and ear itching all statistically decreased compared to baseline at the end of 4 weeks. Conclusion Four-week course of intranasal phototherapy with visible and infrared light leads to clinical improvement in allergic rhinitis patients.
Long-chain polyunsaturated fatty acid supplementation increases levels in red blood cells and reduces the prevalence and severity of squamous gastric ulcers in exercised Thoroughbreds.

OBJECTIVE To assess the relationship between plasma and RBC fatty acid composition and incidence and severity of squamous gastric ulcers when altered by short-chain (SC) or long-chain (LC) polyunsaturated fatty acid (PUFA) supplementation. ANIMALS 13 fit Thoroughbred horses in training. PROCEDURES Horses were evaluated by gastroscopy for squamous ulcer score, gastric pH, and blood fatty acid composition prior to supplementation (UNSUPP) and after 3 months of supplementation with a corn-flax oil blend of alpha-linolenic acid and linoleic acid (SC-PUFA) or a gamma-linolenic acid (GLA)-fish oil blend of GLA, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA; LC-PUFA) in a crossover design. Prior to gastroscopy and blood collection, horses performed a 4,600-m standardized exercise test on the racetrack as a stressor. RESULTS Three months of supplementation with LC-PUFAs increased RBC levels of GLA, dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), EPA, and DHA, and reduced severe ulcer prevalence (38% UNSUPP vs 8% LC-PUFA with a severe ulcer score of grade 3 to 4). Short-chain PUFA supplementation did not effectively elevate RBC GLA, DGLA, AA, EPA, or DHA and severe ulcer incidence was not different (38% UNSUPP vs 23% SC-PUFA with a severe ulcer score of grade 3 to 4). Lower levels of RBC GLA, DGLA, AA, and EPA correlated with severe squamous gastric ulceration (grade 3 to 4). CLINICAL RELEVANCE Equine gastric ulcer syndrome is prevalent in high-performance horses and is a concern to owners and trainers. Long-chain PUFA supplementation increased levels of GLA, DGLA, AA, EPA, and DHA, unlike SC-PUFA supplementation, and was associated positively with prevention or resolution of severe squamous gastric ulceration. Further studies are needed to evaluate different management styles and exercise intensities.
Spectroscopic Determination of Capella’s Photospheric Abundances: Possible Influence of Stellar Activity

Capella is a spectroscopic binary consisting of two G-type giants, where the primary (G8 iii) is a normal red clump giant while the secondary (G0 iii) is a chromospherically active fast rotator showing considerable overabundance of Li as Li-enhanced giants. Recently, Takeda & Tajitsu reported that abundance ratios of specific light elements (e.g., [C/Fe] or [O/Fe]) in Li-rich giants of high activity tend to be anomalously high, which they suspected to be nothing but superficial caused by unusual atmospheric structure due to high activity. Toward verifying this hypothesis, we determined the elemental abundances of the primary and the secondary of Capella based on the disentangled spectrum of each component, in order to see whether any apparent disagreement exists between the two, which should have been formed with the same chemical composition. We found that the primary is slightly supersolar (by ∼+0.1 dex), while the secondary is subsolar (by several tenths of dex) for heavier elements such as Fe, resulting in a marked discrepancy between the primary and secondary, though such a trend is not seen for light elements (e.g., C or O). These observational facts suggest that anomalously large [X/Fe] ratios found in Li-rich giants were mainly due to an apparent decrease of Fe abundance, which we speculate is caused by the overionization effect due to chromospheric UV radiation. We thus conclude that conventional model-atmosphere analysis would fail to correctly determine the abundances of fast-rotating giants of high activity, for which proper treatment of the chromospheric effect is required for deriving true photospheric abundances.
A first look at starlink performance

With new Low Earth Orbit satellite constellations such as Starlink, satellite-based Internet access is becoming an alternative to traditional fixed and wireless technologies with comparable throughputs and latencies. In this paper, we investigate the user-perceived performance of Starlink. Our measurements show that latency remains low and does not vary significantly under idle or lightly loaded links. Compared to another commercial Internet access using a geostationary satellite, Starlink achieves higher TCP throughput and provides faster web browsing. To avoid interference from performance enhancing proxies commonly used in satellite networks, we also use QUIC to assess performance under load and packet loss. Our results indicate that delay and packet loss increase slightly under load for both upload and download.
When satellite is all you have: watching the internet from 550 ms

Satellite Communication (SatCom) offers internet connectivity where traditional infrastructures are too expensive to deploy. When using satellites in a geostationary orbit, the distance from Earth forces a round trip time higher than 550 ms. Coupled with the limited and shared capacity of the physical link, this poses a challenge to the traditional internet access quality we are used to. In this paper, we present the first passive characterization of the traffic carried by an operational SatCom network. With this unique vantage point, we observe the performance of the SatCom technology, as well as the usage habits of subscribers in different countries in Europe and Africa. We highlight the implications of such technology on Internet usage and functioning, and we pin-point technical challenges due to the CDN and DNS resolution issues, while discussing possible optimizations that the ISP could implement to improve the service offered to SatCom subscribers.
Analyzing real-time video delivery over cellular networks for remote piloting aerial vehicles

Emerging Remote Piloting (RP) operations of electrified Unmanned Aerial Vehicles (UAVs) demand low-latency and high-quality video delivery to conduct safe operations in the low-altitude airspace. Although cellular networks are one of the prominent candidates to provide connectivity for such operations, their ground-centric nature limits their capabilities in achieving seamless and reliable aerial connectivity. In this paper, we study the feasibility of supporting RP operations with low latency and high-quality video delivery over commercial cellular networks. By setting up an adaptive bitrate video transmission pipeline with the Google Congestion Control (GCC) and Self-Clocked Rate Adaptation for Multimedia (SCReAM) Congestion Control (CC) algorithms, we analyze the video delivery performance for the RP application requirements and compare the performance of GCC and SCReAM against constant bitrate video delivery. Our results show that low-latency video delivery with < 300 ms playback latency between full-HD and 4K resolution can be maintained up to about 95% of the time in the air. While static bitrate video delivery outperforms adaptive streaming in urban location with abundant link capacity, the latter becomes advantageous in rural locations, where the link capacity is affected by fluctuations. Although the study's findings highlight the capabilities of cellular networks in delivering low-latency video for a safety-critical aerial service, we also discuss the potential improvements and future research challenges for enabling safe operations and meeting the service requirements using cellular networks. We release our collected traces and the video transmission pipeline as open-source to facilitate research in this field.
A Multi-type Classifier Ensemble for Detecting Fake Reviews Through Textual-based Feature Extraction

The financial impact of online reviews has prompted some fraudulent sellers to generate fake consumer reviews for either promoting their products or discrediting competing products. In this study, we propose a novel ensemble model—the Multi-type Classifier Ensemble (MtCE)—combined with a textual-based featuring method, which is relatively independent of the system, to detect fake online consumer reviews. Unlike other ensemble models that utilise only the same type of single classifier, our proposed ensemble utilises several customised machine learning classifiers (including deep learning models) as its base classifiers. The results of our experiments show that the MtCE can adequately detect fake reviews, and that it outperforms other single and ensemble methods in terms of accuracy and other measurements for all the relevant public datasets used in this study. Moreover, if set correctly, the parameters of MtCE, such as base-classifier types, the total number of base classifiers, bootstrap, and the method to vote on output (e.g., majority or priority), can further improve the performance of the proposed ensemble.
The nature of core formation in dark matter haloes: adiabatic or impulsive?

It is well established that the central deficit of dark matter (DM) observed in many dwarf galaxies disagrees with the cuspy DM haloes predicted in the collision-less and cold DM (CDM) model. Plausible solutions to this problem are based on an effective energy deposition into the central halo with an origin that is either based on baryonic physics (e.g. supernova-driven gas blowouts; SNF) or on new DM physics (e.g. self-interacting DM, SIDM). We argue that the fundamental difference between the two is whether the process is impulsive or adiabatic, and explore novel ways to distinguishing them by looking at the response of stellar orbits. We perform idealised simulations of tracers embedded in a $1.48\times 10^{10}{\rm M}_{\odot}$ spherical halo, and model the creation of a $\sim1$kpc DM matter core in SIDM with $\sigma_T/m_{\chi} = 2\,{\rm cm}^2{\rm g}^{-1}$ and through SNF by impulsively removing a mass equivalent to $\mathcal{O}(10\%)$ of the halo's potential energy. Choosing idealised initial orbital configurations for the tracers, we find that radial actions are conserved (changed) in the SIDM (impulsive) case. The adiabaticity of the SIDM case prevents tracers from changing their orbital family during core formation whereas SNF separates tracers of initially the same family to a variety of orbits. We show that these key features remain in a cosmological halo, albeit for a few dynamical timescales. The number density and velocity dispersion profile of a Plummer sphere with $r_{1/2} = 500$ pc change only marginally under adiabatic core formation, whereas SNF causes a substantial expansion of the sphere driving it out of Jeans equilibrium. Our results point towards promising ways of differentiating adiabatic from impulsive core formation.
Nautilus Space Observatory: a very large aperture space telescope constellation enabled by scalable optical manufacturing technologies

We describe progress on the Nautilus Space Observatory concept that is enabled by novel, very large (8.5mdiameter), ultralight-weight, multi-order diffractive lenses that can be cost-effectively replicated. The scientific goal of Nautilus is the rigorous statistical exploration of one thousand potentially life-bearing planets and the assessment of the diversity of exo-earths. Here we review the science requirements and key design features of Nautilus. The new optical technology (MODE lenses) at the heart of the Nautilus telescopes also poses exciting new optical fabrication and metrology challenges. We will summarize these challenges and provide an overview of emerging solutions.
CMB Constraints on Reheating Models with Varying Equation of State

The temperature at the end of reheating and the length of this cosmological phase can be bound to the inflationary observables if one considers the cosmological evolution from the time of Hubble crossing until today. There are many examples in the literature where it is made for single-field inflationary models and a constant equation of state during reheating. We adopt two simple varying equation of state parameters during reheating, combine the allowed range of the reheating parameters with the observational limits of the scalar perturbations spectral index and compare the constraints of some inflationary models with the case of a constant equation of state parameter during reheating.
The History of Low-Mass Star Formation in the Upper Scorpius OB Association

We use a large sample of about 100 low-mass pre–main-sequence (PMS) stars in the Upper Scorpius OB association to explore the star formation history and the initial mass function of this association. Upper Scorpius is an ideal target for such a study, because the star formation process there is finished. The PMS stars have recently been found in a spatially unbiased wide-field survey of X-ray–selected stars in a 160 deg2 area, covering the Upper Scorpius association nearly completely. Following the optical characterization of these PMS stars, we present a new HR diagram for this association. We perform a detailed analysis of the HR diagram, taking proper account of the uncertainties and the effects of unresolved binaries, and derive ages and masses for the PMS stars. We find that the low-mass PMS stars have a mean age of about 5 Myr and show no evidence for a large age dispersion. This agrees very well with the age of 5–6 Myr previously found for the massive stars and shows that low-mass and high-mass stars are coeval and cospatial and thus have formed together. We conclude that the star formation process in Upper Scorpius was probably triggered by the shock wave of a supernova explosion in the nearby Upper Centaurus-Lupus association. After a short burst of very high star formation activity, which lasted only for a few Myr, star formation in Upper Scorpius was halted, probably by the strong winds and the ionizing radiation of the numerous massive stars that dispersed the molecular cloud.
The Effect of Gender-Based Division of Labor on Women's Lives: Domestic Practices of Female Academics

Abstract Subject and purpose of work: This study was designed in order to examine domestic practices of local female academics and to determine to what extent and how these practices affect business life. Materials and methods: In the research phenomenological research design, one of the qualitative research methods, was used. The study group of the research consisted of 20 female faculty members from Turkey. Results: Within the scope of the research, it was concluded that female academics, like other women in the society, undertake a series of gender role-based responsibilities. Conclusions: The results of the research reveal that even women who belong to a profession that requires a high level of education and shows a status in the society, such as academics, take on more responsibilities in home life than their male colleagues. This result also proves that education and status factors are not sufficient to invalidate gender roles and social patriarchy.
RECOVERY OF THE CANDIDATE PROTOPLANET HD 100546 b WITH GEMINI/NICI AND DETECTION OF ADDITIONAL (PLANET-INDUCED?) DISK STRUCTURE AT SMALL SEPARATIONS

We report the first independent, second epoch (re-)detection of a directly imaged protoplanet candidate. Using L′ high-contrast imaging of HD 100546 taken with the Near-Infrared Coronagraph and Imager on Gemini South, we recover “HD 100546 b” with a position and brightness consistent with the original Very Large Telescope/NAos-COnica detection from Quanz et al., although data obtained after 2013 will be required to decisively demonstrate common proper motion. HD 100546 b may be spatially resolved, up to ≈12–13 AU in diameter, and is embedded in a finger of thermal IR-bright, polarized emission extending inward to at least 0. ″3. Standard hot-start models imply a mass of ≈15 MJ. However, if HD 100546 b is newly formed or made visible by a circumplanetary disk, both of which are plausible, its mass is significantly lower (e.g., 1–7 MJ). Additionally, we discover a thermal IR-bright disk feature, possibly a spiral density wave, at roughly the same angular separation as HD 100546 b but 90° away. Our interpretation of this feature as a spiral arm is not decisive, but modeling analyses using spiral density wave theory implies a wave launching point exterior to ≈0. ″45 embedded within the visible disk structure: plausibly evidence for a second, hitherto unseen, wide-separation planet. With one confirmed protoplanet candidate and evidence for one to two others, HD 100546 is an important evolutionary precursor to intermediate-mass stars with multiple super-Jovian planets at moderate/wide separations like HR 8799.