Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantifying spatio-temporal variation in aquaculture production areas in Satkhira, Bangladesh using geospatial and social survey

Despite Bangladesh being one of the leading countries in aquaculture food production worldwide, there is a considerable lack of updated scientific information about aquaculture activities in remote sites, making it difficult to manage sustainably. This study explored the use of geospatial and field data to monitor spatio-temporal changes in aquaculture production sites in the Satkhira district from 2017–2019. We used Shuttle Radar Topographic Mission digital elevation model (SRTM DEM) to locate aquaculture ponds based on the terrain elevation and slope. Radar backscatter information from the Sentinel-1 satellite, and different water indices derived from Sentinel-2 were used to assess the spatio-temporal extents of aquaculture areas. An image segmentation algorithm was applied to detect aquaculture ponds based on backscattering intensity, size and shape characteristics. Our results show that the highest number of aquaculture ponds were observed in January, with a size of more than 30,000 ha. Object-based image classification of Sentinel-1 data showed an overall accuracy above 80%. The key factors responsible for the variation in aquaculture were investigated using field surveys. We noticed that despite a significant number of aquaculture ponds in the study area, shrimp production and export are decreasing because of a lack of infrastructure, poor governance, and lack of awareness in the local communities. The result of this study can provide in-depth information about aquaculture areas, which is vital for policymakers and environmental administrators for successful aquaculture management in Satkhira, Bangladesh and other countries with similar issues.
Temporal aspects of unrealistic optimism and robustness of this bias: A longitudinal study in the context of the COVID-19 pandemic

Numerous studies on unrealistic optimism (UO) have shown that people claim they are less exposed to COVID-19 infection than others. Yet, it has not been assessed if this bias evolves; does it escalate or diminish when the information about the threat changes? The present paper fills this gap. For 12 months 120 participants estimated their own and their peers’ risk of COVID-19 infection. Results show that UO regarding COVID-19 infection is an enduring phenomenon–It was the dominant tendency throughout almost the entire study and was never substituted by Unrealistic Pessimism. While the presence of UO-bias was constant, its magnitude changed. We tested possible predictors of these changes: the daily new cases/deaths, the changes in governmental restrictions and the mobility of participants’ community. Out of these predictors, only changes in governmental restrictions proved to be significant- when the restrictions tightened, UO increased.
Prioritization of carceral spending in U.S. cities: Development of the Carceral Resource Index (CRI) and the role of race and income inequality

Background Policing, corrections, and other carceral institutions are under scrutiny for driving health harms, while receiving disproportionate resources at the expense of prevention and other services. Amidst renewed interest in structural determinants of health, roles of race and class in shaping government investment priorities are poorly understood. Methods Based on the Social Conflict Model, we assessed relationships between city racial/ economic profiles measured by the Index of Concentration at the Extremes (ICE) and budgetary priorities measured by the novel Carceral Resource Index (CRI), contrasting investments in carceral systems with funding for health and social support across the 50 most populous cities in the United States (U.S.). Bivariate correlations, and unadjusted and adjusted polynomial regression models were used to assess the relationship between budgetary investments and population concentration at extremes in terms of income, racial/ethnic composition, and education, controlling for other demographic characteristics. Results In our sample, median CRI was -0.59 (IQR -0.64, -0.45), with only seven cities exhibiting positive CRI values. This indicates that most large U.S. cities spend more on carceral systems than on health and supportive services, combined. Adjusted polynomial models showed a convex relationship between the CRI and ICE-Education, and ICE-Race(White vs. Black)+Income, with quadratic terms that were positive and significant at p<0.05. After controlling for age, the strongest prioritization of carceral systems was observed in cities where the proportion of low-income Black residents approached or exceeded that of high-income white residents. Conclusions Municipal prioritization of carceral investments over health and social support is pervasive in the U.S and exacerbated by racial and economic disparities. The CRI offers new opportunities to understand the role of government investments as a structural determinant of health and safety. Longitudinal research is warranted to examine the relationship between budget priorities, structural racism, and health outcomes.
Trends and characteristics of attempted and completed suicides reported to general practitioners before vs during the COVID-19 pandemic in France: Data from a nationwide monitoring system, 2010–2022

Background Most studies published to date have investigated the impact of the COVID-19 pandemic on suicidal acts using hospital data. Trends from primary care in a country such as France are crucial, as individuals may not consult hospital services after suicide attempts (SAs) but rather see their general practitioner (GP). Objectives We aimed to evaluate whether the incidence and characteristics of SAs and completed suicides (CSs) reported to French GPs were different during the COVID-19 pandemic than those of before. Methods and findings We conducted a retrospective observational study using data from a nationwide monitoring system, the French Sentinel Network (FSN). All SAs and CSs reported by GPs to the FSN from January 1, 2010, to March 10, 2022 were included. The annual incidence rates (IRs) and the characteristics of SAs and CSs during the pandemic (March 11, 2020, to March 10, 2022) were compared to those of before. In total, 687 SAs and 169 CSs were included. The IRs remained stable for SAs and CSs before and during the pandemic (overlap in confidence intervals). The mean IRs were 52 (95%CI = 44; 57) per 100,000 inhabitants for SAs during the pandemic versus 47 [36; 57] during the pre-pandemic period (p = 0.49), and 5 (95%CI = 2; 9) for CSs versus 11 [6; 16] (p = 0.30). During the pandemic, SA were slightly different from those before in terms of age and occupational status (young/students and older/retirees over-represented), history of consultation and expression of suicidal ideas to GP (more frequent), and CS in terms of occupational status (students over-represented) (p<0.05). Conclusion The COVID-19 pandemic had no major effect on the overall incidence of SAs and CSs reported to French GPs. However, more suicidal acts were reported among younger and older individuals. Suicidal patients and GPs have adapted by improving the expression of suicidal ideas.
UGT1A1 variants in Chinese Uighur and Han newborns and its correlation with neonatal hyperbilirubinemia

To explore the correlation between UGT1A1 variant and neonatal hyperbilirubinemia in Chinese Uighur and Han populations. We conducted this study in Urumqi, China. Umbilical cord blood specimens and clinical information of term infants born in the studied center were collected. Variation status of UGT1A1 was determined by direct sequencing or capillary electrophoresis analysis. 102 Uighur and 99 Han normal term neonates, together with 19 hospitalized term newborns (10 Uighur and 9 Han) due to significant hyperbilirubinemia were enrolled into the final analysis. The incidence of neonates with high-risk transcutaneous bilirubin level (TCB) were much higher in Han newborns than in Uighur newborns(P = 0.01). Also, there was statistically significant difference in (TA) 7 promoter mutation of UGT1A1 between Han and Uighur group(χ2 = 4.675, P = 0.03). Furthermore, exon mutation (c.211 and /or c.1091) in UGT1A1 gene was significantly associated with increased TCB level (ORadj = 1.41, 95%CI: 0.25–2.51, P = 0.002) and higher risk of hyperbilirubinemia in both Han and Uighur infants after adjusted for covariates (ORadj = 2.21, 95%CI: 1.09–4.49, P = 0.03). In conclusion, UGT1A1 promoter polymorphism seem to be an important genetic modulator of plasma bilirubin level and neonatal hyperbilirubinemia risk within ethnic groups. Genetic assessment of UGT1A1 coding variants may be useful for clinical diagnosis of neonatal jaundice.
Incidence, time to recovery and predictors among neonates admitted with respiratory distress to the neonatal intensive care unit at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2021

Background One of the major factors contributing to newborn morbidity and mortality across the globe is respiratory distress. In resource-constrained developing nations like Ethiopia, it is a significant issue. Depending on the quality of the care provided, the incidence and time to recovery may differ amongst medical facilities. However, Ethiopia still lacks appropriate data on the incidence and time to recovery from respiratory distress. Objective The aim of the study was to assess the incidence, time to recovery, and predictors among neonates admitted with respiratory distress in the neonatal intensive care unit at the University of Gondar Comprehensive Specialized Hospital. Methods An institution-based retrospective follow-up study design was conducted among 452 neonates with respiratory distress. Data were collected using a data extraction checklist from the medical registry. The extracted data were entered into EPI INFO version 7.2. 1.0 and then exported to STATA version 14 for analysis. The median time to recovery, the Kaplan Meier curve, and the log-rank test was computed. Both bi-variable and multivariable Cox regression models were applied to analyze the data. p-value ≤ 0.05 was considered statistically significant. Results Of all respiratory distressed neonate,311 were recovered. The overall incidence rate of neonates admitted with from respiratory distress was 11.5 per 100-neonate day (95% CI: 10.30–12. 87) with 2,703-person day observation and the median time to recovery from respiratory distress was 7 days with (IQR = 3–13 days). Predictors of time to recovery from respiratory distress were very low birth weight (AHR = 0.17, 95% CI: 0.08–0.41), low birth weight (AHR = 0.50, 95% CI: 0.31–0.81), very preterm (AHR = 0.42,95% CI:0.20–0.89), sepsis (AHR = 0.50 95% CI: 0.38–0.65), hypothermia (AHR = 0.61, 95% CI: 0.39–0.81), and Apgar scores less than seven at first (AHR = 0.35, 95% CI: 0.15–0.79) and fifth minute (AHR = 0.45, 95% CI: 0.20–0.97). Conclusion The incidence and time to recovery in this study were discreetly acceptable as compared to previous study. The aforementioned predictors could be used to identify neonates with respiratory distress who are at risk of developing a long-term illness and guide prompt referral to hospitals. This will also provide clinicians with prognostic information, as longer recovery times have economic and social implications in resource limited countries like Ethiopia.
The association between variables of cardiopulmonary exercise test and quality of life in patients with chronic Chagas cardiomyopathy (Insights from the PEACH STUDY)

Studies investigating the association between functional capacity and quality of life (QoL) in individuals with chronic Chagas cardiomyopathy (CCC) usually do not include a gold-standard evaluation of functional capacity, limiting the validity and the interpretation of the results. The present study is a cross-section analysis aiming to evaluate the association between functional capacity (quantified by cardiopulmonary exercise test [CPET]) and QoL in individuals with CCC. QoL was assessed using the SF-36 questionnaire. Sociodemographic, anthropometric, clinical, cardiac function and maximal progressive CPET variables were obtained from PEACH study. Generalized linear models adjusted for age, sex, and left ventricular ejection fraction were performed to evaluate the association between CPET variables and QoL. After adjustments, VO2 peak and VO2 AT were both associated with physical functioning (β = +0.05 and β = +0.05, respectively) and physical component summary (β = +0.03 and β = +0.03, respectively). Double product was associated with physical functioning (β = +0.003), general health perceptions (β = +0.003), physical component summary (β = +0.002), and vitality (β = +0.004). HRR≤12bpm was associated with physical functioning (β = -0.32), role limitations due to physical problems (β = -0.87), bodily pain (β = -0.26), physical component summary (β = -0.21), vitality (β = -0.38), and mental health (β = -0.19). VE/VCO2 slope presented association with all mental scales of SF-36: vitality (β = -0.028), social functioning (β = -0.024), role limitations due to emotional problems (β = -0.06), mental health (β = -0.04), and mental component summary (β = -0.02). The associations between CPET variables and QoL demonstrate the importance of CPET inclusion for a more comprehensive evaluation of individuals with CCC. In this setting, intervention strategies aiming to improve functional capacity may also promote additional benefits on QoL and should be incorporated as a treatment strategy for patients with CCC.
NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells

Acute myeloid leukemia (AML) stem cells are required for the initiation and maintenance of the disease. Activation of the Wnt/β-catenin pathway is required for the survival and development of AML leukaemia stem cells (LSCs) and therefore, targeting β-catenin is a potential therapeutic strategy. NUC-7738, a phosphoramidate transformation of 3’-deoxyadenosine (3’-dA) monophosphate, is specifically designed to generate the active anti-cancer metabolite 3’-deoxyadenosine triphosphate (3’-dATP) intracellularly, bypassing key limitations of breakdown, transport, and activation. NUC-7738 is currently in a Phase I/II clinical study for the treatment of patients with advanced solid tumors. Protein expression and immunophenotypic profiling revealed that NUC-7738 caused apoptosis in AML cell lines through reducing PI3K-p110α, phosphorylated Akt (Ser473) and phosphorylated GSK3β (Ser9) resulting in reduced β-catenin, c-Myc and CD44 expression. NUC-7738 reduced β-catenin nuclear expression in AML cells. NUC-7738 also decreased the percentage of CD34+ CD38- CD123+ (LSC-like cells) from 81% to 47% and reduced the total number and size of leukemic colonies. These results indicate that therapeutic targeting of the PI3K/Akt/GSK3β axis can inhibit β-catenin signalling, resulting in reduced clonogenicity and eventual apoptosis of AML cells.
A systematic review with meta-analysis of the effects of smoking cessation strategies in patients with rheumatoid arthritis

Objective Smoking rates among patients with rheumatoid arthritis (RA) exceed those in the general population. This study identified smoking cessation strategies used in patients with RA and synthesized data on their effects. Methods We conducted a systematic review of studies that reported effects of interventions for smoking cessation in patients with RA. We searched 5 electronic databases until March 2022. Screening, quality appraisal, and data collection were done independently by 2 reviewers. Results We included 18 studies reporting interventions for patients or providers: 14 evaluated strategies for patients (5 education on cardiovascular risk factors including smoking, 3 educational interventions on smoking cessation alone, 3 education with nicotine replacement and counseling, and 1 study each: education with nicotine replacement, counseling sessions alone, and a social marketing campaign). Smoking cessation rates ranged from 4% (95% CI: 2%-6%, 24 to 48 weeks) for cardiovascular risk education to 43% (95% CI: 21%-67%, 104 weeks) for counseling sessions alone. The pooled cessation rate for all interventions was 22% (95% CI: 8%-41%, 4 weeks to 104 weeks; 9 studies). Four interventions trained providers to ascertain smoking status and provide referrals for smoking cessation. The pooled rates of referrals to quit services increased from 5% in pre-implementation populations to 70% in post-implementation populations. Conclusion Studies varied in patient characteristics, the interventions used, and their implementation structure. Only 3 studies were controlled clinical trials. Additional controlled studies are needed to determine best practices for smoking cessation for patients with RA.
Discovery of Inverse-Compton X-Rays in Radio Lobes

Inverse-Compton (IC) scattering of cosmic microwave background photons into the X-ray band by relativistic electrons in diffuse radio lobes is an obligatory process. We present the strongest evidence to date for the detection of these IC X-rays. They appear in a deep image of the nearby radio galaxy Fornax A (=NGC 1316) obtained with the Position Sensitive Proportional Counter on board the ROSAT satellite. The spatial correspondence of the X-ray and radio emission is excellent. The absence of Faraday depolarization in the lobes argues strongly against the possibility that the X-rays are due to an entrained thermal plasma. The detected level of X-rays is somewhat higher than, but consistent with, that expected from the assumption of equipartition between magnetic fields and relativistic electrons in the lobes. This observation provides the first direct estimate of the magnetic field of a radio lobe, BIC ≃ 2-3 μG, indicating that the integrated energy output of this active galactic nucleus is near the minimum energy level.
Physical conditions for fast reconnection evolution in space plasmas

The present paper studies physical conditions for fast reconnection mechanism involving slow shocks to evolve spontaneously in space (high-temperature) plasmas. This is fundamental for onset mechanisms of geomagnetic substorms and solar flares. It is demonstrated that reconnection evolution strongly depends on effective resistivity available in space plasmas as well as on dimensions of initial current sheet. If a current sheet is sufficiently thin, fast reconnection spontaneously evolves only when resistivity is locally enhanced around X reconnection point. This is because in space plasmas reconnection flows cause vital current concentration locally around X point. For current-driven anomalous resistivity, the resulting resistivity is automatically localized around X point, so fast reconnection mechanism can be realized. On the other hand, for uniform or Spitzer resistivity, any fast reconnection cannot grow; in particular, Spitzer resistivity is reduced around X point because of Joule heating. Regarding .
On the radiative properties of cirrus cloud at solar and thermal wavelengths: A test of model consistency using high‐resolution airborne radiance measurements

Two models describing the single‐scattering properties of cirrus cloud are tested for physical consistency at solar and thermal wavelengths using airborne high‐resolution radiance data. The data were obtained from a case of semi‐transparent cirrus cloud, which occurred north of Scotland during October 2000. The single‐scattering models tested are randomly oriented hexagonal ice columns and randomly oriented ice aggregates. High‐spectral resolution radiances were measured from above the cirrus at a number of wavelengths between 0.3 and 16.7 µm, thereby covering a large range of ice crystal size parameter space and complex refractive index. It is shown that consistency between retrieved optical thickness and ice crystal effective radius at both solar and infrared wavelengths could only be achieved if the ice aggregate model was assumed. Moreover, differences between the ice aggregate model and spectrally resolved brightness temperature measurements were generally well within ±1 K between the wavelengths of 3.3 and 16.0 µm in the clean atmospheric window regions. The paper shows that it is important to have simultaneous radiance measurements from both the solar and thermal spectral regions so that ice crystal scattering models and cirrus retrievals can be rigorously tested. © Crown copyright 2004.
A Quality Index Based on Data Depth and Multivariate Rank Tests

Let F and G be the distribution functions of two given populations on Rp, p ≥ 1. We introduce and study a Parameter Q = Q(F, G), which measures the Overall “outlyingness” of population G relative to population F. The Parameter Q can be defined using any concept of data depth. Its value ranges from 0 to 1, and is . 5 when F and G are identical. We show that within the dass of elliptical distributions when G departs from F in location or G has a larger spread, or both, the value of Q dwindles down from . 5. Hence Q can be used to detect the loss of accuracy or precision of a manufacturing process, and thus it should serve as an important measure in quality assurance. This in fact is the reason why we refer to Q as a quality index in this article. In addition to studying the properties of Q, we provide an exact rank test for testing Q = . 5 vs. Q < . 5. This can be viewed as a multivariate analog of Wilcoxon's rank sum test. The tests proposed here have power against location change and scale increase simultaneo.
Homogeneous buoyancy‐generated turbulence

If a random and statistically homogeneous density distribution is created in a fluid, a random motion of the fluid is subsequently generated by buoyancy forces. This motion is resisted by viscous stresses, while the density variation is smoothed by molecular diffusion of the relevant scalar property of the fluid. Furthermore, advective mixing generates smaller‐scale components of the scalar quantity, increasing the rate of smoothing. If the Reynolds number of the motion is sufficiently large, the motion becomes turbulent in the ordinary sense. Such turbulence may be said to be generated by an ‘‘active’’ conserved scalar quantity. To elucidate the nature of this buoyancy‐driven turbulence, we consider an infinite fluid that is initially at rest everywhere, with a given distribution of the conserved scalar quantity. In order to have a well‐defined initial state specified by a manageably small number of parameters, the initial distribution of the scalar is assumed to be statistically homogeneous and isotropi.
A re-determination of the mixture curves of the spectrum

The paper describes a method that has been developed for calculating the sensation curves and mixtures curves from an average set of trichromatic coefficients and the standard luminosity curve, without recourse to any further experimental data. A complete table of colour mixture data is given. The practical value of different methods of colorimetry and the most desirable primaries for use as reference standards are briefly discussed.
On the bandwidth of diffusors based upon the quadratic residue sequence

The lower and upper frequency boundary are discussed within which a diffusor based upon the quadratic residue sequence shows its typical operation. Using a qualitative model of the diffusor’s way of operation these limits are found to be related with the diffusor’s width and well width, respectively. Therefore, the prime number N on which the underlying quadratic residue sequence is constructed is an indicator for the bandwidth. The choice of the design frequency is discussed.