Miracle-dz/UniFAR-FTUs huggingface dataset:
Intelligence in Children with Focal Epilepsy Brain Network Architecture and Global

BACKGROUND AND PURPOSE: The biologic basis for intelligence rests to a large degree on the capacity for efﬁcient integration of information across the cerebral network. We aimed to measure the relationship between network architecture and intelligence in the pediatric, epileptic brain. MATERIALS AND METHODS: Patients were retrospectively identiﬁed with the following: 1) focal epilepsy; 2) brain MR imaging at 3T, including resting-state functional MR imaging; and 3) full-scale intelligence quotient measured by a pediatric neuropsychologist. The cerebral cortex was parcellated into approximately 700 gray matter network “nodes. ” The strength of a connection between 2 nodes was deﬁned by the correlation between their blood oxygen level–dependent time-series. We calculated the following topologic properties: clustering coefﬁcient, transitivity, modularity, path length, and global efﬁciency. A machine learning algorithm was used to measure the independent contribution of each metric to the intelligence quotient after adjusting for all other metrics. RESULTS: Thirty patients met the criteria (4–18 years of age); 20 patients required anesthesia during MR imaging. After we accounted for age and sex, clustering coefﬁcient and path length were independently associated with full-scale intelligence quotient. Neither motion parameters nor general anesthesia was an important variable with regard to accurate intelligence quotient prediction by the machine learning algorithm. A longer history of epilepsy was associated with shorter path lengths ( P (cid:2) . 008), consistent with reorganization of the network on the basis of seizures. Considering only patients receiving anesthesia during machine learning did not alter the patterns of network architecture contributing to global intelligence. CONCLUSIONS: These ﬁndings support the physiologic relevance of imaging-based metrics of network architecture in the pathologic, developing brain.
Pengujian Galur Kedelai di Lahan Pasang Surut

Testing of soybean genotypes were conducted at six locations of tidal swampland; in dry season of 1999/2000. Eight genotypes and two checks varieties i.e. Wilis and Slamet were evaluated for their yield potential. The experiment was using Randomized Completely Block Design with four replications. The result showed that yield of two genotypes, MSC 9/12-D-4 and MSC 9243-D-3, were higher and relatively stable compared to Wilis and Slamet. Key words Soybean, Tidal swampland
The Effects of Structure and Oxidative Polymerization on Antioxidant Activity of Catechins and Polymers

Polyphenols are key free radical scavengers in tea. This study screened the antioxidant active groups of catechins and dimers and analyzed the effects of the degree of oxidative polymerization and oxidative dimerization reaction on their antioxidant activities. ABTS+· free radical scavenging activity, DPPH free radical scavenging activity, and total antioxidant capacity of catechins and polymers were systematically analyzed and compared in this study. Results manifested antioxidant activities of catechins were dominated by B-ring pyrogallol and 3-galloyl, but were not decided by geometrical isomerism. 3-galloyl had a stronger antioxidant activity than B-ring pyrogallol in catechins. The number, not the position, of the galloyl group was positively correlated with the antioxidant activities of theaflavins. Theasinensin A has more active groups than (−)-epigallocatechin gallate and theaflavin-3,3′-digallate, so it had a stronger antioxidant activity. Additionally, the higher the degree of oxidation polymerization, the weaker the antioxidant activities of the samples. The oxidative dimerization reaction hindered the antioxidant activities of the substrate–catechin mixture by reducing the number of active groups of the substrate and increasing the molecular structure size of the product. Overall, pyrogallol and galloyl groups were antioxidant active groups. The degree of oxidative polymerization and the oxidative dimerization reaction weakened the antioxidant activity.
Clinical and Radiographic Outcomes of a Monoblock Fluted Titanium Tapered Stem Following Complex and Revision Total Hip Arthroplasty

Abstract Achieving femoral stem stability in complex primary and revision total hip arthroplasty (rTHA) cases is a challenging goal that monoblock fluted titanium tapered stems (FTTS) were designed to address. However, as more modern FTTS are developed, there are still questions regarding outcomes for these stems. The purpose of this study is to determine the radiographic and clinical outcomes of a modern monoblock FTTS. A multicenter retrospective observational study examined the hip databases of three institutions to obtain all monoblock FTTS with up to 5 years of radiographic follow-up. Stem subsidence and osteointegration were assessed on the most recent radiograph. All-cause re-revisions and survival of the stem at latest follow-up were recorded. Descriptive statistics were calculated for demographics and outcomes. Ninety-six monoblock FTTS were examined. Median clinical follow-up was 28.5 months (range: 18.0–57.8 months). Median subsidence was 1.4 mm (range: 0–15.0 mm). Sixteen (16.7%) and 3 (3.1%) stems had subsidence greater than 5 and 10 mm, respectively. Overall, thirteen hips (13.5%) required reoperations, of which 5 stems were revised (5.2%). Four stems were revised for periprosthetic joint infection (PJI), and one stem was explanted for exposure during acetabular revision. Kaplan–Meier analysis yielded an all-cause stem survivorship of 95.8% at 2 years and 88.5% at 4 years. Stem survivorship excluding septic causes for revision was 99.0% at both 2 and 4 years. Monoblock FTTS in complex primary and rTHA demonstrate encouraging clinical and radiographic results at up to 5 years of follow-up.
Epidemiology and Management of Hypertension and Diabetes Mellitus in Patients with Mild Autonomous Cortisol Secretion: A Review

Mild autonomous cortisol secretion (MACS) is associated with a higher cardiometabolic risk than that observed in patients with nonfunctioning adrenal adenomas and in the general population. In patients with MACS, the excess of glucocorticoids affects various metabolic pathways, leading to different manifestations of metabolic syndrome and other comorbidities. Hypertension and diabetes mellitus are two of the most common cardiometabolic comorbidities associated with MACS, reaching a prevalence of up to 80% and up to 40%, respectively. In addition, they are the comorbidities that experienced a greater improvement after adrenalectomy in patients with MACS. Hypertension pathogenesis is multifactorial, including the coexistence of comorbidities such as obesity or diabetes and the role of the different polymorphisms of the glucocorticoid receptor gene, among others. Glucocorticoid-induced diabetes mellitus is mainly related to the detrimental effects of glucocorticoids on insulin-dependent glucose uptake in peripheral tissues, gluconeogenesis and insulin secretion. There are no specific recommendations for hypertension and diabetes treatment in patients with MACS. Thus, considering the similar underlying pathogenesis of hypertension and diabetes mellitus in overt and mild hypercortisolism, our recommendation is to follow this general stepwise approach: surgically remove the adrenal culprit lesion to induce remission from hypercortisolism; control hypercortisolism with steroidogenesis inhibitors; and treat elevated blood pressure or high glucose levels using carefully selected anti-hypertensives and glucose-lowering medications if blood pressure and glucose levels remain uncontrolled, respectively. In this review, we summarize the epidemiology, physiopathology and management of diabetes mellitus and hypertension in patients with MACS.
New structural constraints on the southern Provence thrust belt (France): evidences for an Eocene shortening event linked to the Corsica-Sardinia subduction

The Eocene shortening directions along the Southern Provence fold-and-thrust belt are commonly assumed to be N-S. We present here new observations and data that allow reinterpreting the structure of the La Nerthe range as a right-lateral transpressive flower structure. Structural data collected along the range argue for an Eocene N145o shortening event. The age of this shortening event is constrained by the fact that faulting and folding affect the Late Cretaceous-Paleocene continental deposits along the northern flank of the La Nerthe range and is sealed by the Miocene marine deposits. Moreover striated fault planes display both horizontal and vertical striae suggesting that they were reactivated during the Oligocene extensional event. We question here the shortening directions along the Southern Provence thrust belt. Structural data suggest both N-S and NNW-SSE shortening directions during the Eocene. During the Eocene the Provence area was in the foreland of a complex orogenic belt that extended from the Betic Cordillera to the Corsica-Sardinia block. This orogenic belt developed along the subduction linked to the convergence between Africa and Eurasia. Although the convergence vector was nearly N-S the NE-SW orientation of the trench may have led to a complex deformation pattern along the orogenic belt with NW-SE and N-S shortening directions that reflected both the along-trench compression and the regional convergence.
THE IMPACT OF DIETARY NITRATES AND ACRYLAMIDE INTAKE ON SYSTEMIC REDOX STATUS IN HEALTHY YOUNG ADULTS

Objectives: The nitrogen-containing xenobiotics, such as nitrates and acrylamide may potentially influence systemic redox status and contribute to the generation of oxidative stress (OS) in the human body, but there is still a lack of studies that would evaluate the various parameters assessing the oxidative-antioxidant balance. The aim of this study was to evaluate the exposure to nitrates and acrylamide derived from daily diet and to analyze the impact of these nitrate-containing xenobiotics on the parameters of systemic redox status in healthy young adults. Material and Methods: To assess nitrate and acrylamide intake in the study population, a semi-quantitative food frequency questionnaire was used. Systemic redox status was evaluated by measurement of a panel of biochemical parameters: enzymatic (glutathione S-transferase, glutathione reductase, glutathione peroxidase [GPx]) and non-enzymatic (uric acid, bilirubin and albumin), thiol/disulphide homeostasis parameters (total thiol, native thiol, and disulfide) and oxidative/antioxidant balance indicators (total antioxidant status, total oxidant status, OS index). Results: The average consumption of nitrates and acrylamide in the study population was 1.24 mg/kg b.w. /day and 0.23 µg/kg b.w. /day, respectively, which is within the normal value range. Of 12 measured parameters, significant differences were revealed for disulfide and total thiol levels, which were increased in the subgroup with the highest daily intake of nitrates compared to the subgroup with the lowest intake; for GPx, which was highest in the subgroup of the lowest daily intake of acrylamide; and for native thiols in the subgroup with the highest daily intake. Conclusions: The intake of nitrogen-containing xenobiotics within the range considered as normal does not markedly influence redox state parameters in healthy young adults. Some significant changes were revealed only for thiol/disulphide homeostasis parameters, which may be the first line of antioxidant defense, as well as for GPx activity. Compensative mechanisms in healthy young people are efficient enough to neutralize OS induced by slightly increased exposure to nitrogen-containing xenobiotics delivered with food.
Submission to the Inquiry into Issues Surrounding Cyber-Safety for Indigenous Australians

Executive Summary: This submission has been prepared by researchers from the Home Internet for Remote Communities Project (HIP). HIP is a collaborative project between the Centre for Appropriate Technology, Central Land Council and Swinburne University that aims to investigate the feasibility of home-based computing and internet access in three small remote communities in Central Australia. The nature and prevalence of cyber-bullying and other risks and threats, in particular via social networking sites and mobile phones, amongst Indigenous Australians Based on the limited available evidence, one of the most threatening aspects of the use of mobile phones and social networking platforms for cyber-bullying for community members in remote Central Australian settlements is its potential to cross personal, social, cultural and geographical boundaries rapidly. The misuse of ICT technologies in Indigenous contexts has the capacity to breach cultural protocols between family and intra-familial groups and, in doing so, to inflame existing conflicts. Our experience with the HIP to date suggests that incidents of cyber-bullying are more likely to be reported in relation to larger communities and regional centres with mobile coverage. Whether and how these risks and threats differ in rural and remote Indigenous communities Many remote Indigenous community members, especially older and middle-aged people, are characterised by low levels of digital literacy and experience of communication technologies. Without further education and skills development in ICT use, they are likely to find dealing with cyber-safety issues particularly distressing and challenging. The impact and implications of cyber-bullying and other risks and threats on access and use of information and communication technologies by Indigenous Australians Poor understanding of cyber-bullying and lack of mechanisms to address this issue may lead to a reluctance amongst some remote communities to adopt mobile and satellite ICT. This in turn may see some communities denied potential benefits such as connections to e-health, education, training and employment opportunities. Ways to support indigenous communities, including rural and remote Indigenous communities, to reduce the incidence and harmful effects of cyber-bullying and other risks and threats Education and awareness programs which consider the limited exposure to computers and the internet, and low digital literacy skills of many remote Indigenous people, need to be developed. Ideally, these programs would be delivered in conjunction with the introduction of ICT infrastructure such as mobile coverage into new areas. Community members across all age groups should be engaged in developing approaches to manage any local cyber-safety issues. It is important to involve elders, because they have the authority to provide leadership to younger people about what is culturally appropriate in regard to use of ICTs.
Modelling spatial distribution of soil types and characteristics in a high Alpine valley (Val di Sole, Italy)

SUMMARY - Modelling spatial distribution of soil types and characteristics in a high Alpine valley (Val di Sole, Trentino, Italy) - Detailed soil maps in Alpine areas are often not available due to the high variability of the topography, the inaccessibility of parts of the area and consequently high production costs. In the context of growing demand for high-resolution spatial information for environmental planning and modelling, fast and accurate methods are needed to provide high-quality digital soil maps. We performed a spatial analysis to model several characteristics of Alpine soils in Val di Sole, Val di Peio and Val di Rabbi (in total 374 km 2 ). Soil modelling was performed using a non-parametric classification and decision tree analysis (CART: Classification and Regression Tree Analysis). The classification and decision tree analysis used forced splitting rules (according to expert knowledge). Soil type modelling was done using 15 end nodes. Spatial modelling of humus forms could be achieved with 9 terminal nodes. Field and chemical data (115 sites) served as a basis for modelling. In addition, conventional soil mapping was performed on three relatively small test areas. The modelling results could therefore be tested using these maps. Modelling of soils and humus forms was performed successfully with an accuracy of about 65% for soil types and higher values (up to 78%) for the humus forms. The main soil type in the investigation area is a ranker (WRB:
Optimal Treatment Strategies for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma: A Real-World Triple Cohort Analysis Using Propensity Score Matching

Purpose This study aims to identify the most effective treatment approach and compares the survival rates, along with complications, in patients with locally resectable esophageal squamous cell carcinoma (ESCC) who were treated with one of the three treatment patterns: neoadjuvant chemotherapy followed by surgery (NCT+S), neoadjuvant chemoradiotherapy followed by surgery (NCRT+S), or surgery followed by chemoradiotherapy (S+CRT). Methods We conducted a retrospective analysis of the medical records of ESCC patients who received one of these treatments between March 2015 and March 2022. This analysis aimed to identify differences in long-term survival, pathological responses, and complications across the three treatment groups. To address potential confounding factors, propensity score matching (PSM) and Cox proportional hazards models were utilized. Results This study included a cohort of 715 patients: 197 in the NCT+S group, 188 in the NCRT+S group, and 330 in the S+CRT group, all meeting the selection criteria. After PSM, the median disease-free survival (DFS) time was 38.9 months, 25.6 months, and 15.3 months for NCRT+S, NCT+S, and S+CRT groups, respectively. There were statistically significant differences in the 5-year DFS and 5-year OS among the three groups (P=0.04 and P=0.02, post-matching, respectively). Notably, neoadjuvant therapy showed a correlation with increased postoperative anastomotic leakage rates (17.5% in NCRT+S, 10% in NCT+S, and 5% in S+CRT; P=0.03, post-matching), regardless of the PSM adjustment. Conclusion The findings indicate that neoadjuvant therapy before surgery offers a significant survival advantage over postoperative adjuvant therapy for patients with locally advanced resectable ESCC. Despite similar safety profiles, neoadjuvant therapy appears to be associated with a higher incidence of anastomotic leakage after surgery.
INTRAVALLEY VARIATION IN SLOPE ANGLES RELATED TO MICROCLIMATE AND EROSIONAL ENVIRONMENT

East- or west-trending stream valleys that have erosional slopes have been reported to be (1) asymmetrical with the north-facing slopes steeper, (2) asymmetrical with the south-facing slopes steeper, and (3) symmetrical, with both sides of equal mean slope angle. A series of measurements of angles of erosional slopes, taken in three east-trending, low-gradient valleys in the Laramie Range, Wyoming, shows that north-facing slopes there tend to be 4.4° steeper than opposed south-facing slopes; slope angle is further affected by nearness to the channel. In valleys that have channel gradients greater than 6° and greatly differing vegetation density across the valley, measurements of slope angles definitely show valley symmetry. The interpretation given is that unless the channel has been maintained against the base of the north-facing slope by greater slope wash from the south-facing slope, vegetation differences and resulting rates of slope erosion alone do not produce asymmetric valleys. Valley asymmetry that results from a variety of basic causes can be attributed to a single mechanism, asymmetric lateral corrosion by the stream. Difference in frost action on north-and south-facing valley sides is rejected as a cause of valley asymmetry in the areas studied because (1) the asymmetry is opposite that reported in tundra regions elsewhere, and (2) the degree of asymmetry in two widely separated areas does not reflect differences in the degree of frost activity in the two areas.
Discontinuous Daily Temperatures in the WATCH Forcing Datasets

AbstractThe Water and Global Change (WATCH) forcing datasets have been created to support the use of hydrological and land surface models for the assessment of the water cycle within climate change studies. They are based on 40-yr ECMWF Re-Analysis (ERA-40) or ECMWF interim reanalysis (ERA-Interim) with temperatures (among other variables) adjusted such that their monthly means match the monthly temperature dataset from the Climatic Research Unit. To this end, daily minimum, maximum, and mean temperatures within one calendar month have been subjected to a correction involving monthly means of the respective month. As these corrections can be largely different for adjacent months, this procedure potentially leads to implausible differences in daily temperatures across the boundaries of calendar months. We analyze day-to-day temperature fluctuations within and across months and find that across-months differences are significantly larger, mostly in the tropics and frigid zones. Average across-months differe.
Analysis Of The Influence Of Sustainability Reporting, Auditor Switching, And Good Corporate Governance On Going Concern Audit Opinion

Going concern is a basic assumption of financial statements preparation, where the company must able to maintain its operational survival in the present and also be able to continue the business in the future. The purpose of this study is to test the influence of sustainability reporting, auditor switching, and good corporate governance as measured through variables of managerial share ownership, independent commissioners, board of directors, and audit committees on the provision of audit opinions on the going concern of coal sub-sector companies listed on the Indonesia Stock Exchange in 2016-2020. This research uses a quantitative method research. This research used logistic regression for data analysis using Eviews 12. The research results show that the variables of sustainability reporting, auditor switching, and good corporate governance measured through managerial share ownership, independent commissioners, board of directors, and audit committee simultaneously affect audit opinions. Furthermore, managerial share ownership variables positively influence the provision of audit opinions going concern. In addition, the independent commissioner variable negatively influences the provision of audit opinions. Meanwhile, the variables of sustainability reporting, switching auditors, board of directors, and audit committees have no partial effect on the provision of audit opinions going concern
Size and transparency influence diel vertical migration patterns in copepods

Diel vertical migration (DVM) is a widespread phenomenon in aquatic environments. The primary hypothesis explaining DVM is the predation‐avoidance hypothesis, which suggests that zooplankton migrate to deeper waters to avoid detection during daylight. Copepods are the predominant mesozooplankton undergoing these migrations; however, they display massive morphological variation. Visual risk also depends on a copepod's morphology. In this study, we investigate hypotheses related to morphology and DVM: (H1) as size increases visual risk, increases in body size will increase DVM magnitude and (H2) if copepod transparency can reduce visual risk, increases in transparency will reduce DVM magnitude. In situ copepod images were collected across several cruises in the Sargasso Sea using an Underwater Vision Profiler 5. Copepod morphology was characterized from these images and a dimension reduction approach. Although in situ imaging offers challenges for quantifying mesozooplankton behavior, we introduce a robust method for quantifying DVM. The results show a clear relationship in which larger copepods have a larger DVM signal. Darker copepods also have a larger DVM signal, however, only among the largest group of copepods and not smaller ones. These findings highlight the complexity of copepod morphology and DVM behavior.