Miracle-dz/UniFAR-FTUs huggingface dataset:
VLBI imaging of M 81* at 43 GHz

Context. The nearby spiral galaxy M 81 harbours in its core a low-luminosity active galactic nucleus (LLAGN), and appears to be closely related to the more distant and powerful active galactic nuclei (AGNs) seen in quasars and radio galaxies. The intrinsic size of this object is unknown because of too much scattering, and it has shown a core-jet morphology with weak extended emission rotating with wavelength. Aims. The proximity of M 81 (D = 3.63 Mpc) allows for a detailed investigation of its nucleus. The nucleus is four orders of magni- tude more luminous than the Galactic centre, and is therefore considered to be a link between Sgr Aand the more powerful nuclei of radio galaxies and quasars. Our main goal was to determine the size of M 81 ∗ at a shorter wavelength to directly test whether the frequency-size dependent law Θ ∝ ν −0.8 is still valid for wavelengths shorter than 1 cm. In addition, we also aimed to confirm the rotation of the source as a function of frequency. Methods. We observed the continuum 7 mm radio emission of M 81 ∗ with the Very Long Baseline Array on Sep. 13, 2002, using nearby calibrators to apply their interferometric observables to the target source to increase the chances of detection. The source was detected on all baselines and hybrid mapping was possible. Results. We present the first 7 mm VLBI image of the core of M 81 ∗ , which is the highest resolution image ever of this source. Modelling the interferometric visibilities with two Gaussian functions sets constraints on the angular size of its core down to 38 microarcseconds, corresponding to a maximum (projected) linear size of 138 AU, and shows extended emission towards the NE with a position angle of ∼50 ◦ . A fit of a one Gaussian elliptical function yields a position angle of 28 ± 8 degrees for its elon- gated, compact structure. Combining the 7 mm size with earlier measurements at other frequencies, we determine a frequency-size dependence of Θ ∝ ν (−0.88±0.04) . Conclusions. Our VLBI imaging of M 81 ∗ has clearly detected its core-jet structure, and has allowed us to estimate a size for its core, with a minimum size of 138 AU (≈100 Schwarzschild radii). Our work opens the way for future observations of M 81 ∗ at high-angular resolution, including the monitoring of its structure, given that much higher bandwidths are currently available on the interferometric networks. In particular, this would allow one to test for possible proper motions of the core or of its components in the inner jet of M8 1 ∗ , and for the speed of the detected jet components.
ANTENATAL CARE VISITS IN PREECLAMPTIC PATIENTS BEFORE AND DURING NATIONAL HEALTH INSURANCE (NHI)PROGRAM

 Health care financing was one of the health problems associated with access to health services. In addition, it also affectedto the increase in maternal mortality ratio (MMR) caused by conditions of pregnancy and childbirth with common complications that could be pressed with quick access to quality obstetric services. The cause of maternal death was known as "4 T" (too old, too young, too often and too much) and “3T” (too late in making decisions, too late in carrying, and too late in getting service). One of the efforts made by the Indonesian government to help accelerate MMR reduction was to implement the National Health Insurance (NHI) Program with easier access to health services with an affordable financing system that effected to health services by doing antenatal care routinely and quality. But in fact, during the implementation of the NHI program there was still contributed to high numbersofMMR and preeclampsia/eclampsia remained the main cause of maternal death. This study aims to determine the characteristics of antenatal care visits in mothers with preeclampsia that occurred in the era before and during the implementation of NHI program (2012-2016) in Dr. Soetomo Hospital Surabaya, Indonesia.This was a descriptive cross sectional study in tertiary hospital. The sample was patient who diagnosed preeclampsia in Dr. Soetomo Hospital in the period 2012 to 2016 and was taken by proportionally simple random sampling with total samples were 252 patients. The data extracted from medical record. The results showed that in the era before and during NHI, most of thepatients included in the age group of 20-35 years and the majority did antenatal care visits quite well (≥4 times). In the era during NHI, even women with risky age of <20 years and or> 35 years who visited antenatal care <4 times experienced an increase in proportion compared to the era before NHI (39.4%). In both eras, there were similarities that mothers who did antenatal care visits quite well (≥4 times) had an education level dominated by higher education (64.9% before NHIvs 78.6% during NHI). Most of the patients with the frequency of antenatal care visits were quite well dominated by housewives even increased during NHI (65.8%). In the era before NHI dominated by primiparous with antenatal care visits were quite well (≥4 times) but differentduring NHI which was dominated by multiparous mothers. In the case of severe preeclampsia and preeclampsia in both eras tended to have antenatal care visits were quite well. It is necessary to improve the quality of antenatal care services from health services toprevent the development of complications due to late detection of
April 2011 No. 11 Aid Effectiveness:

Frot and Maria Perrotta Working papers from Stockholm Institute of Transition Economics (SITE) are preliminary by nature, and are circulated to promote discussion and critical comment. The views expressed here are the authors’ own and not necessarily those of the Institute or any Abstract Despite a voluminous literature on the topic, the question of whether aid leads to growth is still controversial. To observe the pure eﬀect of aid, researchers used instruments that must be exogenous to growth and explain well aid ﬂows. This paper argues that instruments used in the past do not satisfy these conditions. We propose a new instrument based on predicted aid quantity and argue that it is a signiﬁcant improvement relative to past approaches. We ﬁnd a signiﬁcant and relatively big eﬀect of aid: a one standard deviation increase in received aid is associated with a 1.6 percentage points higher growth rate.
DYNAMIC CONDYLAR SCREW IN SUBTROCHANTERIC FRACTURES OF FEMUR-AN IDEAL OPTION IF DONE IN THE BEST WAY

Objective: To study the results of 31patients with subtrochanteric fractures of the femur, treated surgically with fixation by dynamic condylar screw at a secondary care hospital of Kerala, India between June 2012 and May 2017 . Methods: The patients were reviewed with the mean follow-up of 28.90 weeks (range- 8 to 104 weeks) postoperatively. The mean duration of union was 10.61 weeks (range 6 to 12 weeks). One fracture was found malunited in varus. Excellent or good clinical and radiological scoring was achieved in 23patients (74%); but fair in 8(26%). Conclusions: We concluded that DCS is an ideal option for treating subtrochanteric fractures of femur considering its reasonable functional outcome and easy availability.
HIGH SENSITIVITY C-REACTIVE PROTEIN AND PLASMA LIPIDS IN TYPE 2DIABETIC PATIENTS IN ENUGU, NIGERIA.

Background: Type II Diabetes is a worldwide health problem. It exerts a heavy economic burden on the society and is associated with microvascular and macrovascular complications. Objective: This study on high sensitivity C-reactive protein (hs-CRP) and plasma lipids in type II diabetic patients was carried out to have a baseline data of hs-CRP and plasma lipids in type II diabetics and its relation to glycaemic control. Methods: In this cross-sectional study 150 known type II diabetics and 100 age-matched non diabetics without inflammatory conditions were used as controls. Fasting plasma glucose, lipids and hs-CRP were assayed, Body mass index was calculated by using the Quetelet formula [weight (Kg)/height (m 2 )]. Values presented as mean ± 2standard deviations. Student’s t test and Chi-square tests were used to compare the means and proportion between two groups respectively. Pearson correlation was utilised in comparing the relationship between the hs-CRP and other parameters. Results: In the diabetics the following plasma parameters were significantly higher (p<0.05) than in the non-diabetic controls. In mmol/L, glucose 5.44± 1.19(4.88±1.41), TC 6.03±1.16(5.01±1.39), LDL Cholesterol 5.28±1.43(3.90±1.27), TG1.12±0.58(0.81±0.29); hs-CRP 0.12±0.10mg/dl(0.07±0.04), BMI29.04±5.72Kg/ m 2 (23.62±5.22) There was a significant decrease in HDL Cholesterol in diabetics than in the non-diabetic controls, 1.38±0.25mmol/L (1.47±0.38). Pearson’s Correlation Coefficient for hs-CRP and BMI is 0.119(p>0.05 and was not significant). Conclusion: Data shows that there are significant increases in the parameters measured in all the diabetic subjects except in HDL-cholesterol where there is significant reduction when compared with the control (P<0.05). There is no significant correlation between the hsC-reactive protein and BMI (P>0.05). The results concluded that total Cholesterol, triglyceride, low density lipoprotein cholesterol and hs–CRP have strong associations with type 2 diabetes mellitus, the significance of these associations was discussed.
Rnning title: Acyl-coenzyme A: cholesterol acyltransferase family Acyl-coenzyme A: cholesterol acyltransferase family

The enzymes of the acyl-coenzyme A: cholesterol acyltransferase (ACAT) family are responsible for the in vivo synthesis of neutral lipids. They are potential drug targets for the intervention of atherosclerosis, hyperlipidemia, obesity, type II diabetes and even Alzheimer’s disease. ACAT family enzymes are integral endoplasmic reticulum (ER) membrane proteins and can be divided into ACAT branch and acyl-coenzyme A: diacylglycerol acyltransferase 1 (DGAT1) branch according to their substrate specificity. The ACAT branch catalyzes synthesis of cholesteryl esters using long-chain fatty acyl-coenzyme A and cholesterol as substrates, while the DGAT1 branch catalyzes synthesis of triacylglycerols using fatty acyl-coenzyme A and diacylglycerol as substrates. In this review, we mainly focus on the recent progress in the structural research of ACAT family enzymes, including their disulfide linkage, membrane topology, catalysis
b -Amylase Induction and the Protective Role of Maltose during Temperature Shock 1

A number of studies have demonstrated b -amylase induction in response to abiotic stress. In the present work, a temperature response proﬁle in 5 (cid:1) C increments from 45 (cid:1) C to 0 (cid:1) C showed that induction at temperature extremes was speciﬁc for two members of the gene family (BMY7 and BMY8). Both members encode proteins that possess apparent transit peptides for chloroplast stromal localization. However, induction was not observed for other key starch degrading enzymes demonstrating a rather speciﬁc response to temperature stress for BMY7 and BMY8. Time course experiments for heat shock at 40 (cid:1) C and cold shock at 5 (cid:1) C showed that b -amylase induction correlated with maltose accumulation. Maltose has the ability, as demonstrated by in vitro assays, to protect proteins, membranes, and the photosynthetic electron transport chain at physiologically relevant concentrations. Therefore, b -amylase induction and the resultant maltose accumulation may function as a compatible-solute stabilizing factor in the chloroplast stroma in response to acute temperature stress. Production of NADH was followed for 20 s at A 340 using a Lambda 3A UV/VIS spectrophotometer (Perkin-Elmer). A time course experiment was conducted where ADH was treated in the absence and in the presence of 400 m M maltose, Glc, Suc, and trehalose at 53.5 (cid:1) C for 0, 5, 10, 15, 20, and 25 min.
Induction of Receptor for Advanced Glycation End Products by Epstein-Barr virus Latent Membrane Protein 1, and its Correlation with Angiogenesis and Cervical Lymph Node Metastasis in Nasopharyngeal Carcinoma

Abbreviations used are: AGE, advanced glycation end product; EBV, Epstein-Barr virus; LMP1, latent membrane protein 1; MMP, matrix metalloproteinase; NF- κ B, nuclear factor- κ B; NPC, nasopharyngeal carcinoma; RAGE, receptor for advanced glycation end products; VEGF, vascular endothelial growth ABSTRACT Purpose: The EBV oncoprotein, latent membrane protein 1 (LMP1), contributes to the metastasis of nasopharyngeal carcinoma (NPC) by inducing factors to promote tumor invasion and angiogenesis. The receptor for advanced glycation endproducts (RAGE) is associated with abnormal angiogenesis in diabetic microangiopathies. Moreover, some papers have suggested the association of RAGE overexpression with tumor metastasis; thus, the associations of RAGE with LMP1 and angiogenesis in NPC were examined. Experimental Design: Forty-two patients with NPC were evaluated for expressions of LMP1, RAGE, and S100 proteins, and for microvessel counts by immunohistochemistry. Then, the RAGE-induction by LMP1 was examined with Western blotting and luciferase reporter assay. Results: The microvessel counts were significantly higher in patients with high LMP1 expression or high RAGE expression compared to cases with low expressions ( P = 0.0049 and P <0.0001), respectively. Patients with advanced N classification were also significantly increased in these groups ( P = 0.0484 and P = 0.0005). The expressions of LMP1 and RAGE proteins were clearly correlated in NPC tissues ( P = Transient transfection with LMP1 expression plasmid induced RAGE protein in Ad-AH cells. The expression of LMP1 transactivated the RAGE promoter as demonstrated by luciferase reporter assay. Mutation of the reporter at nuclear factor- κ B (NF- κ B) binding site (-671 to -663) abolished transactivation of the RAGE promoter by LMP1. Conclusion: These results suggest that LMP1-induced RAGE enhances lymph node metastasis through the induction of angiogenesis in NPC. NF- κ B binding site (-671 to -663) is essential for transactivation of the RAGE promoter by LMP1.
La situación laboral del paciente con enfermedad renal crónica en función del tratamiento sustitutivo renal

La enfermedad renal cronica (ERC) es una patologia limitante, sin embargo estan demostrados los beneficios que la actividad laboral produce en estos pacientes. La modalidad de tratamiento sustitutivo renal (TSR) puede influir sobre dicha actividad laboral. Objetivos: Analizar la situacion laboral de las personas con ERC en funcion del TSR: hemodialisis (HD), dialisis peritoneal manual (DPCA), dialisis peritoneal automatica (DPA) o trasplante (Tx). Metodos: Analisis descriptivo de la situacion laboral de 243 pacientes renales de ambos sexos entre 16 y 64 anos, que llevan a cabo TSR con HD, DPCA, DPA o Tx en 8 hospitales espanoles. Resultados: Solo el 33,3% de los pacientes con insuficiencia renal en edad laboral estan trabajando. Se observan diferencias estadisticamente significativas en el porcentaje de ocupados entre hombres (40,1%) y mujeres (22,9%), entre la edad media de los ocupados (43,5 anos) y los no ocupados (49,6 anos), y tambien en el tiempo medio de tratamiento de ocupados (4,8 anos) y no ocupados (7,9 anos). Por ultimo, existen tambien diferencias en el porcentaje de ocupados en funcion del TSR consideradas, siendo el mas elevado en los pacientes en DPA (47,8%), y el menor, el de los pacientes en HD (21,7%). Conclusiones: La ERC y los TSR son un importante factor de incapacidad laboral. Los pacientes en activo optan mayoritariamente por un tratamiento de DPA; casi la mitad de los pacientes en DPA estan trabajando, mientras que en HD apenas trabaja uno de cada cinco pacientes en edad laboral.
Pharmacological targeting of 34 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity

receptors Abstract Aims/hypothesis Treatment with the α 3 β 4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose tolerance in diet-induced obese (DIO) mice, but the physiological and molecular mechanisms are unknown. Methods DMPP (10 mg/kg body weight, s.c.) was administered either in a single injection (acute) or daily for up to 14 days (chronic) in DIO wild-type (WT) and Chrnb4 knockout (KO) mice and glucose tolerance, tissue-specific tracer-based glucose metabolism, and insulin signalling were assessed. Results In WT mice, but not in Chrnb4 KO mice, single acute treatment with DMPP induced transient hyperglycaemia, which was accompanied by high plasma adrenaline (epinephrine) levels, upregulated hepatic gluconeogenic genes, and decreased hepatic glycogen content. In contrast to these acute effects, chronic DMPP treatment in WT mice elicited improvements in glucose tolerance already evident after three consecutive days of DMPP treatment. After seven days of DMPP treatment, glucose tolerance was markedly improved, also in comparison with mice that were pair-fed to DMPP-treated mice. The glycaemic benefit of chronic DMPP was absent in Chrnb4 KO mice. Chronic DMPP increased insulin-stimulated glucose clearance into brown adipose tissue (+69%), heart (+93%), gastrocnemius muscle (+74%) and quadriceps muscle (+59%), with no effect in white adipose tissues. After chronic DMPP treatment, plasma adrenaline levels did not increase following an injection with DMPP. In glucose-stimulated skeletal muscle, we detected a decreased phosphorylation of the inhibitory Ser640 phosphorylation site on glycogen synthase and a congruent increase in glycogen accumulation following chronic DMPP treatment. Conclusions/interpretation Our data suggest that DMPP acutely induces adrenaline release and hepatic glycogenolysis, while chronic DMPP-mediated activation of β 4-containing nAChRs improves peripheral insulin sensitivity independently of changes in body weight via mechanisms that could involve increased non-oxidative glucose disposal into skeletal muscle.
Head-Body Motion Coordination for Human Aware Robot Navigation

Mobile robots equipped with a pan-tilt head need to use gaze direction to manifest its navigational intents for more acceptable human-robot interaction. We frame control of such gaze behavior as multi-criteria decision-making problem, and provide a solution to synchronize gaze control with robot's navigation planner. This approach is useful in the context of robot navigation, where it may be inapt to display only a predefined gaze pattern due to the dynamic nature of the scene. By enabling two behaviors, look-at-path and glance-at-human, we demonstrate the effectiveness of our approach on a real robotic platform in a path crossing scenario. Furthermore, we discuss results of a video based user study conducted with 126 participants showing improved communication of robot's navigational intentions with the proposed approach.
Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of chronic obstructive pulmonary disease

Rationale. Chronic obstructive pulmonary disease (COPD) is characterised by an abnormal inflammatory response to mainly cigarette smoke that flares up during exacerbations of the disease (ECOPD). A reduced activity of histone deacetylases (HDAC) contributes to enhanced inflammation in stable COPD. We hypothesised that HDAC activity is further reduced during ECOPD, and that theophylline, an HDAC activator, potentiates the anti-inflammatory effect of steroids in these patients. Objectives. To investigate HDAC activity during ECOPD and the effects of theophylline on the anti-inflammatory effects of steroids in a randomised, single-blinded, controlled study. Methods. Thirty-five patients hospitalised because of ECOPD and treated according to international guidelines (including systemic steroids) were randomised to receive (or not) low dose oral theophylline (100 mg bid). Before treatment and 3 months after discharge we measured HDAC and nuclear factor- κ B (NF- κ B) activity in sputum macrophages, the concentration of nitric oxide in exhaled gas (eNO), and total anti-oxidant status (TAS), TNF- α , IL-6 and IL-8 levels in sputum supernatants. Measurements and Main results. Patients receiving standard therapy showed decreased NF- κ B activity, eNO concentration and sputum levels of TNF- α , IL-6 and IL-8, as well as increased TAS during recovery of ECOPD, but HDAC activity did not change. The addition of low-dose theophylline increased HDAC activity (p=0.02) and further reduced IL-8 (p=0.012) and TNF- α concentrations (p=0.031). Conclusions. During ECOPD, low dose theophylline increases HDAC activity and improves the anti-inflammatory effects of steroids.
Running Head: Adaptability and Psychological Flexibility Adaptability and psychological flexibility: Overlapping constructs?

Adaptability is purported to be a key mental resource and refers to an individual’s cognitive, behavioral, and emotional regulation (or adjustment) in situations of change, novelty, and uncertainty. Psychological flexibility refers to a person’s capacity to allow experience and acceptance of negative thoughts and feelings with mindful awareness guided by a commitment to goal-driven action according to their self-chosen values. It is important to disentangle these cognate constructs—adaptability and psychological flexibility—so that the unique variance attributable to each can be estimated, and interventions and resources can be directed with greater precision. The current study explored the potential overlap between adaptability and psychological flexibility by conducting an online cross-sectional survey ( n = 205), with measures of adaptability, psychological flexibility, wellbeing, and psychological distress. A confirmatory factor analysis suggested considerable overlap, but sufficient discrimination between the two constructs. Structural equation modelling showed that adaptability was related to psychological wellbeing, but not related to psychological distress after accounting for the effects of psychological flexibility.