Miracle-dz/UniFAR-FTUs huggingface dataset:
The Heterogeneous Surface of Asteroid (16) Psyche

Main‐belt asteroid (16) Psyche is the largest M‐type asteroid, a class of object classically thought to be the metal cores of differentiated planetesimals and the parent bodies of the iron meteorites. de Kleer, Cambioni, and Shepard (2021, https://doi.org/10.3847/psj/ac01ec) presented new data from the Atacama Large Millimeter Array (ALMA), from which they derived a global best‐fit thermal inertia and dielectric constant for Psyche, proxies for regolith particle size, porosity, and/or metal content, and observed thermal anomalies that could not be explained by surface albedo variations only. Motivated by this, here we fit a model to the same ALMA data set that allows dielectric constant and thermal inertia to vary across the surface. We find that Psyche has a heterogeneous surface in both dielectric constant and thermal inertia but, intriguingly, we do not observe a direct correlation between these two properties over the surface. We explain the heterogeneity in dielectric constant as being due to variations in the relative abundance of metal and silicates. Furthermore, we observe that the lowlands of a large depression in Psyche's shape have distinctly lower thermal inertia than the surrounding highlands. We propose that the latter could be explained by a thin mantle of fine regolith, fractured bedrock, and/or implanted silicate‐rich materials covering an otherwise metal‐rich surface. All these scenarios are indicative of a collisionally evolved world.
Therapeutic and prophylactic applications of self-replicating RNA viruses

Self-replicating RNA viruses have been commonly used for preventive and therapeutic interventions in the fields of infectious diseases and cancers. Both RNA viruses with single-stranded RNA genomes of positive and negative polarity have been utilized. Expression of viral surface proteins from self-replicating RNA virus vectors has elicited strong immune responses and provided protection against challenges with lethal doses of pathogens in various animal models using recombinant viral particles, RNA replicons, or plasmid-based replicon vectors. Similarly, immunization with self-replicating RNA virus vectors expressing tumor antigens has induced tumor-specific antibody (Ab) responses, inhibited tumor growth, eradicated tumors, and protected immunized animals against tumor challenges. Clinical trials have demonstrated good safety and tolerance of self-replicating RNA viruses. Although the number of clinical trials is low, robust immune responses and protection against challenges with pathogens and tumor cells have been achieved. The Ervebo vaccine against Ebola virus disease has been approved by both the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA).
An Adaptation of the RAND/UCLA Modified Delphi Panel Method in the Time of COVID-19

Abstract The RAND/UCLA modified Delphi panel method is a formal group consensus process that systematically and quantitatively combines expert opinion and evidence by asking panelists to rate, discuss, then re-rate items. The method has been used to develop medical society guidelines, other clinical practice guidelines, disease classification systems, research agendas, and quality improvement interventions. Traditionally, a group of experts meet in person to discuss results of a first-round survey. After the meeting, experts complete a second-round survey used to develop areas of consensus. During the COVID-19 pandemic, this aspect of the method was not possible. As such, we have adapted the method to conduct virtual RAND/UCLA modified Delphi panels. In this study, we present a targeted literature review to describe and summarize the existing evidence on the RAND/UCLA modified Delphi panel method and outline our adaptation for conducting these panels virtually. Transitioning from in-person to virtual meetings was not without challenges, but there have also been unexpected advantages. The method we describe here can be a cost-effective and efficient alternative for researchers and clinicians.
Evaluation of Pharmacogenetics of Drug-Metabolizing Enzymes and Drug Efflux Transporter in Renal Transplants Receiving Immunosuppressants

Cytochrome P450 (CYP) enzymes, such as CYP3A4, and CYP3A5, P450 oxidoreductase (POR), peroxisome proliferator activated receptor alpha (PPAR-alpha), and drug transporter (ABCB1) were observed to influence concentrations of immunosuppressants (cyclosporine, everolimus, sirolimus, and tacrolimus) and outcomes in renal transplants. We carried out the present study to evaluate the prevalence and impact of these single nucleotide polymorphisms (SNPs) in adult renal transplants. SNPs were evaluated using commercial TaqMan® assays. Serum drug concentrations were estimated using immunoassays. One hundred and forty-six patients were recruited. SNPs in CYP3A5*3 were significantly associated with greater dose-adjusted cyclosporine and tacrolimus concentrations. SNPs in POR*28 were observed with significantly lower dose-adjusted concentrations, particularly with cyclosporine and tacrolimus. ABCB1 homozygous polymorphisms were observed with significantly lower time spent in the therapeutic range with cyclosporine and everolimus/sirolimus. Cyclosporine was observed in a significantly greater proportion of patients with elevated GGT, and SNPs in PPAR-alpha were significantly associated with an increased risk of this adverse event. Hypertriglyceridemia with everolimus was significantly associated with POR*28 polymorphisms. There is a need to validate the influence of these SNPs in a prospective study and develop an algorithm predicting the achievement of target concentrations.
Impacts of Cigarette Smoke (CS) on Muscle Derangement in Rodents—A Systematic Review

Cigarette smoke (CS) is the major risk factor for chronic obstructive pulmonary disease (COPD) and can induce systemic manifestations, such as skeletal muscle derangement. However, inconsistent findings of muscle derangement were reported in previous studies. The aim of the present study was to consolidate the available evidence and assess the impact of CS on muscle derangement in rodents. A comprehensive literature search of five electronic databases identified ten articles for final analysis. Results showed that the diaphragm, rectus femoris, soleus, and gastrocnemius exhibited significant oxidative to glycolytic fiber conversions upon CS exposure. In contrast, the extensor digitorum longus (EDL), plantaris, and tibialis did not exhibit a similar fiber-type conversion after CS exposure. Hindlimb muscles, including the quadriceps, soleus, gastrocnemius, and EDL, showed significant reductions in the CSA of the muscle fibers in the CS group when compared to the control group. Changes in inflammatory cytokines, exercise capacity, and functional outcomes induced by CS have also been evaluated. CS could induce a shift from oxidative fibers to glycolytic fibers in high-oxidative muscles such as the diaphragm, rectus femoris, and soleus, and cause muscle atrophy, as reflected by a reduction in the CSA of hindlimb muscles such as the quadriceps, soleus, gastrocnemius, and EDL.
Understanding the characteristics of workforce transformation in a digital transformation context

ABSTRACT Current literature has increased our knowledge of particular aspects of Workforce Transformation (WT), yet we need a comprehensive picture of its characteristics within a Digital Transformation (DT) context. Therefore, the objective of this review paper is to present the defining characteristics of WT. We fulfil this objective through a systematic review of 70 empirical papers published in leading journals listed on the CABS Academic Journal Guide (between 2010 and 2022). Following an inductive open coding approach, we identified six characteristics of WT: (1) ‘Actors and Digital Competency’; (2) ‘Digital Culture’; (3) ‘Digitally Engaged Workspace’; (4) ‘Empowerment, Engagement, and Motivation’; (5) ‘Improvisation and Collaborative Visioning’; and (6) ‘Transformational Leadership and Governance’. Based on these characteristics, we detail a future research agenda that proposes the need to examine the relationship between WT characteristics and DT outcomes.
Multi-Locus Association Mapping Uncovers the Genetic Basis of Yield and Agronomic Traits in Chile Pepper (Capsicum spp.)

Genome-wide association studies (GWAS) are one of the foundations for modern molecular breeding for plant genetic improvement. Single-locus GWAS methodologies impose constraints in association mapping due to the complex nature of quantitative traits and the often-stringent thresholds used. Multi-locus models, therefore, serve as alternative approaches in identifying significant marker-trait associations. This study used six multi-locus models to determine quantitative trait loci (QTL) associated with yield and agronomic traits in a diverse population of chile pepper evaluated in New Mexico, USA. Using the GWAS models, eight genotyping-by-sequencing (GBS)-derived single nucleotide polymorphism (SNP) markers across six chromosomes were identified to be associated with multiple traits. Plant height shared similar genetic control with plant width, whereas total yield per plant had common QTL with yield components. Epigenetic mechanisms such as methylation and chromatin remodeling and organization were predicted for first pod date and flowering time. The diverse functions of candidate genes identified reflect the complex genomic architecture of the evaluated traits. Allele specific assays for the identified QTL will be developed and validated for marker-assisted selection and genome-wide selection towards the genetic improvement of chile pepper.
Fraction of Inspired Oxygen With Low-Flow Versus High-Flow Devices: A Simulation Study

Purpose: The fraction of inspired oxygen while administering oxygen to patients must be measured as it represents the alveolar oxygen concentration, which is important from a respiratory physiology viewpoint. Therefore, the purpose of this study was to compare the fractions of inspired oxygen obtained through different oxygen delivery devices. Methods: A simulation model of spontaneous respiration was used. The fractions of inspired oxygen obtained through low- and high-flow nasal cannulas and a simple oxygen mask were measured. The fraction of inspired air was measured every second for 30 s after 120 s of oxygen administration. This was measured three times under each condition. Results: With a low-flow nasal cannula, airflow reduced both the intratracheal fraction of inspired oxygen and extraoral oxygen concentration, indicating that exhalatory respiration occurred during rebreathing and may be involved in increasing the intratracheal fraction of inspired oxygen. Conclusion: Oxygen administration during expiratory flow may lead to an increased oxygen concentration in the anatomical dead space, which may be involved in the increase in the fraction of inspired oxygen. With a high-flow nasal cannula, a high fraction of inspired oxygen can be achieved even at a flow rate of 10 L/min. When determining the optimum amount of oxygen, it is necessary to set an appropriate flow rate for patients and specific conditions without being bound by the fraction of inspired oxygen values alone. It might be difficult to estimate the fraction of inspired oxygen while using a low-flow nasal cannula and simple oxygen mask in clinical situations.
Applying Artificial Intelligence to Predict Complications After Endovascular Aneurysm Repair

Objective: Complications after Endovascular Aneurysm Repair (EVAR) can be fatal. Patient follow-up for surveillance imaging is becoming more challenging as fewer patients are seen, particularly after the first year. The aim of this study was to develop an artificial intelligence model to predict the complication probability of individual patients to better identify those needing more intensive post-operative surveillance. Methods: Pre-operative CTA 3D reconstruction images of AAA from 273 patients who underwent EVAR from 2011-2020 were collected. Of these, 48 patients had post-operative complications including endoleak, AAA rupture, graft limb occlusion, renal artery occlusion, and neck dilation. A deep convolutional neural network model (VascAI©) was developed which utilized pre-operative 3D CT images to predict risk of complications after EVAR. The model was built with TensorFlow software and run on the Google Colab Platform. An initial training subset of 40 randomly selected patients with complications and 189 without were used to train the AI model while the remaining 8 positive and 36 negative cases tested its performance and prediction accuracy. Data down-sampling was used to alleviate data imbalance and data augmentation methodology to further boost model performance. Results: Successful training was completed on the 229 cases in the training set and then applied to predict the complication probability of each individual in the held-out performance testing cases. The model provided a complication sensitivity of 100% and identified all the patients who later developed complications after EVAR. Of 36 patients without complications, 16 (44%) were falsely predicted to develop complications. The results therefore demonstrated excellent sensitivity for identifying patients who would benefit from more stringent surveillance and decrease the frequency of surveillance in 56% of patients unlike to develop complications. Conclusion: AI models can be developed to predict the risk of post-operative complications with high accuracy. Compared to existing methods, the model developed in this study did not require any expert-annotated data but only the AAA CTA images as inputs. This model can play an assistive role in identifying patients at high risk for post-EVAR complications and the need for greater compliance in surveillance.
Disinfecting Action of Gaseous Ozone on OXA-48-Producing Klebsiella pneumoniae Biofilm In Vitro

Klebsiella pneumoniae is an emerging multidrug-resistant pathogen that can contaminate hospital surfaces in the form of a biofilm which is hard to remove with standard disinfectants. Because of biofilm resistance to conservative disinfectants, the application of new disinfection technologies is becoming more frequent. Ozone gas has antimicrobial activity but there is lack of data on its action against K. pneumoniae biofilm. The aim of this study was to investigate the effects and mechanisms of action of gaseous ozone on the OXA-48-procuding K. pneumoniae biofilm. A 24 h biofilm of K. pneumoniae formed on ceramic tiles was subsequently exposed to different concentrations of ozone during one and two hours to determine the optimal ozone concentration. Afterwards, the total bacteria count, total biomass and oxidative stress levels were monitored. A total of 25 ppm of gaseous ozone was determined to be optimal ozone concentration and caused reduction in total bacteria number in all strains of K. pneumoniae for 2.0 log10 CFU/cm2, followed by reduction in total biomass up to 88.15%. Reactive oxygen species levels significantly increased after the ozone treatment at 182% for the representative K. pneumoniae NCTC 13442 strain. Ozone gas in the concentration of 25 ppm caused significant biofilm reduction but did not completely eradicate the K. pneumoniae biofilm formed on ceramics. In conclusion, ozone gas has great potential to be used as an additional hygiene measure in joint combat against biofilm in hospital environments.
Long-Term Trends in Laying date and Fledged Young of Barn Swallow Hirundo rustica in Two Regions of the Netherlands

Since 1992, Dutch volunteers have monitored the breeding attempts of Barn Swallows on a systematic basis. For two regions – Noord-Veluwe and Twente – a dataset of 27 years (1992–2018) was available. This paper examines the timing of breeding and the number of fledglings per successful breeding attempt. As spring and summer weather in Western Europe became on average warmer during this period, we analysed whether Barn Swallows adapted to this shift. The laying date of first broods advanced on average 2.3 days per ten years. The average advancement of laying date of second broods was 2.9 days per decade. The average number of fledglings per successful breeding attempt was constant over time, but showed large inter-year-variation. First broods consistently produced 0.6 fledglings more than second broods. These results are in line with results from similar studies in Western Europe. Contrary to our expectations, neither large scale nor local weather parameters were found to explain the advancement of laying and the number of fledged young. It is essential to study key species like Barn Swallows during all stages of their life cycle over a long time span and large spatial scale to be able to unravel potential effects of climate change. Our study demonstrates that volunteers can contribute essential demographic data. Ideally, these demographic parameters would be monitored with individually marked (colour-ringed) birds. Frequent quality checks and feedback to volunteers are key to maximize the quality of the data collected through long-term volunteer surveys.
Implementation of Contractor Safety Management System as a Requirement for Partners at a Petrochemical Company

Introduction: Data Report Safety Performance Indicator for Oil and Gas Producers (OGP) in 2018 recorded 2 deaths at the company and 29 deaths occurred to the contractors, with Fatal Accident Rate (FAR) in the company of 0.31 accidents per 1 million working hours and in contractors of 1.20 accidents per 1 million work hours. PT Pupuk Kujang as a petrochemical company has a high-risk of implementation of Contractor Safety Management Systemn (CSMS) to protect safety of contractors. This research aims to evaluate the implementation of Contractor Safety Management System (CSMS). Methods: This study was a descriptive study with an observational method for data collection, and this study was cross-sectional. The variable studied was Contractor Safety Management System (CSMS) including CSMS stages and documents. Results: PT Pupuk Kujang has implemented six stages for the implementation of Contractor Safety Management System (CSMS), namely identification and risk assessment, prequalification, selection, initial work activities, assessment during work, and final assessment of work. However, some shortcomings were observed in the implementation of pre-qualification stage where before being declared to have passed the pre-qualification assessment stage, a local contractor has been appointed as the winner of the tender. Conclusion: The implementation of Contractor Safety Management System (CSMS) at PT Pupuk Kujang still does not run well because there are deficiencies in the prequalification stage.Keywords: contractor safety management system, pt pupuk kujang, prequalification
Pharmacological inhibition of SK‐channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events

Obstructive sleep apnea (OSA) creates a complex substrate for atrial fibrillation (AF), which is refractory to many clinically available pharmacological interventions. We investigated atrial antiarrhythmogenic properties and ventricular electrophysiological safety of small‐conductance Ca2+‐activated K+ (SK)‐channel inhibition in a porcine model for obstructive respiratory events.
Correlation between gray values of cone-beam computed tomograms and Hounsfield units of computed tomograms: A systematic review and meta-analysis

Purpose The aim of this review was to systematically analyze the available literature on the correlation between the gray values (GVs) of cone-beam computed tomography (CBCT) and the Hounsfield units (HUs) of computed tomography (CT) for assessing bone mineral density. Materials and Methods A literature search was carried out in PubMed, Cochrane Library, Google Scholar, Scopus, and LILACS for studies published through September 2021. In vitro, in vivo, and animal studies that analyzed the correlations GVs of CBCT and HUs of CT were included in this review. The review was prepared according to the PRISMA checklist for systematic reviews, and the risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. A quantitative analysis was performed using a fixed-effects model. Results The literature search identified a total of 5,955 studies, of which 14 studies were included for the qualitative analysis and 2 studies for the quantitative analysis. A positive correlation was observed between the GVs of CBCT and HUs of CT. Out of the 14 studies, 100% had low risks of bias for the domains of patient selection, index test, and reference standards, while 95% of studies had a low risk of bias for the domain of flow and timing. The fixed-effects meta-analysis performed for Pearson correlation coefficients between CBCT and CT showed a moderate positive correlation (r=0.669; 95% CI, 0.388 to 0.836; P<0.05). Conclusion The available evidence showed a positive correlation between the GVs of CBCT and HUs of CT.
Experimental Study on Tribological Properties of Polymer-based Composite Nano-additives Suitable for Armored Vehicle Engine Lubricating Oil

Lubricating oil is known as "the blood to maintain the normal operation of machinery", and additives are an indispensable and important part of lubricating oil. In this paper, the Polymer-based Composite Nano-additive (PCNA) suitable for armored vehicle engine lubricating oil was developed, the physical and chemical properties of lubricating oil containing additives were carried out. The results showed that adding an appropriate amount (3 vol.%) of additives could improve the low-temperature fluidity of lubricating oil and improve the kinematic viscosity of lubricating oil without affecting the viscositytemperature characteristics of lubricating oil. The four-ball testing machine, high temperature end face testing machine and engine bench are used to measure the anti-friction lubrication effect and anti-wear ability improvement effect of the additive on lubricating oil. The experimental results show that the additive can effectively improve the antifriction, lubrication and anti-wear performance of lubricating oil. In addition, the addition of the additive can effectively improve the running state of the engine, and the engine noise is obviously reduced. Finally, the additives developed in this paper are compared with three common brand additives in the market by using the high temperature end face testing machine. The results show that the additive developed in this paper has certain advantages in improving the antifriction and lubrication effect of lubricating oil.
Skin Barrier Enhancing Alternative Preservation Strategy of O/W Emulsions by Water Activity Reduction with Natural Multifunctional Ingredients

Water activity (aw) as an important parameter for self-preservation can help to control microbial growth in cosmetic formulations. However, high amounts of water-binding substances are required to lower the aw enough to affect microbial growth. Since consequences for the skin barrier have been poorly studied so far, we investigated the effect of aw-lowering agents on both the antimicrobial properties of o/w emulsions and skin physiological parameters. A combination of selected natural humectants (Sodium lactate, Propanediol, Erythritol, Betaine and Sodium PCA) with a total concentration of 28 wt% in an o/w emulsion was able to reduce its aw from 0.980 ± 0.003 to 0.865 ± 0.005. The challenge test results of the aw-lowered emulsion showed a convincing microbial count reduction in potentially pathogenic microorganisms. The addition of as little as 0.5% of the antimicrobial multifunctionals Glyceryl Caprylate and Magnolia Officinalis Bark Extract further enhanced the antimicrobial effect, resulting in adequate antimicrobial protection. Moreover, twice-daily application of the aw-lowered emulsion for a period of four weeks led to a skin barrier-enhancing effect: TEWL significantly decreased, and SC hydration significantly increased. Thus, we present an opportunity to replace conventional preservatives with a natural alternative preservation strategy that has been shown to offer benefits for the skin.