Miracle-dz/UniFAR-FTUs huggingface dataset:
Delft University of Technology Comparison of ZEB1 and Leica C10 indoor laser scanning point clouds

We present a comparison of point cloud generation and quality of data acquired by Zebedee (Zeb1) and Leica C10 devices which are used in the same building interior. Both sensor devices come with different practical and technical advantages. As it could be expected, these advantages come with some drawbacks. Therefore, depending on the requirements of the project, it is important to have a vision about what to expect from different sensors. In this paper, we provide a detailed analysis of the point clouds of the same room interior acquired from Zeb1 and Leica C10 sensors. First, it is visually assessed how different features appear in both the Zeb1 and Leica C10 point clouds. Next, a quantitative analysis is given by comparing local point density, local noise level and stability of local normals. Finally, a simple 3D room plan is extracted from both the Zeb1 and the Leica C10 point clouds and the lengths of constructed line segments connecting corners of the room are compared. The results show that Zeb1 is far superior in ease of data acquisition. No heavy handling, hardly no measurement planning and no point cloud registration is required from the operator. The resulting point cloud has a quality in the order of centimeters, which is fine for generating a 3D interior model of a building. Our results also clearly show that fine details of for example ornaments are invisible in the Zeb1 data. If point clouds with a quality in the order of millimeters are required, still a high-end laser scanner like the Leica C10 is required, in combination with a more sophisticated, time-consuming and elaborative data acquisition and processing approach.
Etiology and types of necrotizing periodontal diseases

The burden of periodontal disease has significantly increased over the past decade due to the increasing prevalence rates and trends of the different etiologies and risk factors. Periodontal diseases are associated with infections, tissue destruction, pain, and discomfort, and the diagnosis of the condition is usually clinical, while the pathology involves the periodontium and the surrounding structures. Many conditions were reported to affect the periodontium, including pericoronitis, pericoronal abscess, combined periodontal-endodontic lesions, ABSTRACT
SPE ANTEC Orlando 2018 / 1 DAMAGE INDUCED SURFACE TEXTURING OF SHORT FIBER-PDMS COMPOSITE MATERIALS

Damage induced surface texturing (DIST) is a newly developed technique based on fiber debonding and pullout in composite materials. This method consists of two stages in the first stage fibers incorporated in the compliant material and during the second stage, the composite is cut perpendicular to the direction of aligned fibers to generate the textured surface. In the present study, we show that a random alignment of fibers inside the substrate also leads to generating surfaces with added functionalities indicating that DIST is not limited to aligning fibers transversally to the cut direction. Characterization of the produced composite demands thorough investigation of process parameters like matrix and fiber stiffness, fiber geometry, fiber volume percent ratio. In the present study, surface textured composites are produced using polydimethylsiloxane (PDMS) as the compliant material, which has been reinforced with various fibers to manipulate the surface functionality of the cut surface. The results indicate that increasing fiber elastic modulus, fiber diameter and fiber tensile strength will increase debonding and pullout length. In contrast, enhancing critical strain energy release rate (G2c), matrix modulus, the friction coefficient between fiber and matrix and fiber/matrix misfit strain can decrease debonding and pullout length. Furthermore, we show that increased debonding and pullout lengths impart the generated surfaces with increased hydrophobicity.
Green juice . GPx : Glutathione peroxidase . GSH : Glutathione . OJ : Orange juice . RS : Reactive species . SOD : Superoxide dismutase

Universidade Federal de Pelotas. Campus Universitário. Pelotas. RS. Brazil. Centro de Ciências Químicas, Farmacêuticas e de Alimentos. Curso de Farmácia. Universidade Federal de Pelotas. Pelotas. RS. Brazil. Programa de Pós-Graduação em Bioquímica e Bioprospecção. Universidade Federal de Pelotas. Pelotas. RS. Brazil. Departamento de Ciéncias Básicas da Saúde. Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. RS. Brazil.
Effect of nitrogen on growth and yield of medicinal plants: A review paper

Medicinal plants are those plants which are used for medicinal purposes. Medicinal plants are come under herbalism (herbal medicine). From the ancient time herbal plants were used for medicinal purposes. India was rich in medicinal plants from prehistoric time. Different parts of plants are used for medicinal purposes. It has been observed that the contribution of USA in medicinal plants is just 25% whereas India contributes 80% of its share. Medicinal plants are used to treat skin problems, eye irritation, diarrhea, sleeplessness and nausea. The medicinal plants like tulsi, ginger, turmeric and aloe are used for curing several common ailments. Nitrogen is one of the essential plant nutrients. It plays an important role in the life cycle of plant. Nitrogen is the main constituent of amino acids, proteins and chlorophyll. Nitrogen increases the vegetative growth of plants. It also increases the oil content present in the medicinal plants.
and Is Independent of CD4 T Cell Help Memory CD8 T Cells Occurs Stochastically Homeostatic Turnover of Virus-Specific

Memory CD8 T cells persist by Ag-independent homeostatic proliferation. To examine the dynamics of this cell turnover, we transferred lymphocytic choriomeningitis virus speciﬁc memory CD8 T cells into naive mice and analyzed their in vivo division kinetics longitudinally in individual recipients.Using mathematical modeling, we determined that proliferation of this stably maintained memory CD8 T cell population was homogeneous and stochastic with a small fraction of cells completing division at any given time with an intermitotic interval of 50 d. This homeostatic turnover was comparable between memory CD8 T cells of different viral epitope speciﬁcities and also the total memory phenotype (CD44 high ) CD8 T cells. It is well established that CD4 T cell help is critical for maintenance of CD8 T cells during chronic infections, but recent studies have suggested that CD4 T cell help is also required for maintenance of memory CD8 T cells following acute infections. Hence, we assessed the role of CD4 T cells in Ag-independent maintenance of memory CD8 T cells. Consistent with previous reports, we found that memory CD8 T cells declined when transferred into MHC class II-deﬁcient mice. However, their numbers were maintained stably when transferred into CD4 T cell-deﬁcient mice. Interestingly, their homeostatic proliferation, ability to make recall responses, and phenotype were independent of CD4 T cell help because none of these qualities were affected when memory CD8 T cells were transferred and maintained in either MHC class II- or CD4-deﬁcient recipients. The Journal of Immunology , 2010, 185: 3436–3444.
Implication of peroxynitrite in defence responses of potato to <i>Phytophthora infestans</i>

M. Arasimowicz-Jelonek*, J. Floryszak-Wieczorek, K. Izbia nska, J. Gzyl and T. Jelonek Department of Plant Ecophysiology, Faculty of Biology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznan; Department of Plant Physiology, Poznan University of Life Sciences, Wołynska 35, 60-637 Poznan; and Department of Forest Utilization, Poznan University of Life Sciences, Wojska Polskiego 71A, 60-625 Poznan, Poland
Preterm Morbidity and Mortality by Gestational Age. A Birth Population-Based Study

Bo Sun (  bsun@shmu.edu.cn ) Children's Hospital of Fudan University Xiaojing Guo Children's Hospital of Fudan University Xiaoqiong Li Huai'an Women and Children's Hospital Tingting Qi Huai'an Women and Children's Hospital Zhaojun Pan Huai'an Women and Children's Hospital Xiaoqin Zhu Huai'an Women and Children's Hospital Hui Wang Huai'an Women and Children's Hospital Ying Dong Children's Hospital of Fudan University Hongni Yue Huai'an Women and Children's Hospital
Generation of Antigen-specific Suppressor Cells as a Consequence of Anti-I-A Antibody Treatment In Vivo

Cell surface glycoproteins encoded by the I region of the murine major histocompatibility complex play a central role in regulating lymphoid cell interactions. Macrophage-T cell (1, 2) and T cell-B cell (3, 4) collaborations are dependent upon homology at this region, in most cases mapping to the I-A subregion of the H-2 complex. Because it has not been possible to separate by recombination I regionassociated (Ia) antigen expression and immune response (Ir) gene phenotypes of inbred mouse strains, it appears that Ia antigens may be the vehicles of Ir gene function (5). This is supported by biochemical and functional studies on the genetic control of Ia antigen synthesis (6, 7). T cells (8), B cells (9, 10), and macrophages (11, 12) have all been implicated as possible sites of Ir gene expression, although the precise mechanism(s) of gene action are still a matter of conjecture (13). Immune responsiveness to antigens under Ir gene control has been modulated experimentally through the use of antibodies specific for the cell surface products of these loci. Inhibition of antigen-specific T cell proliferation in vitro has been accomplished using monoclonal anti-Ia antibodies specific for the controlling Ia subregion (14), or, in the case of antigens under complementing Ir gene control, with antibodies raised against the hybrid Ia determinant (5). Such antibodies act at the level of the macrophage under these conditions (15) and function, at a minimum, by blocking T cell binding to I-A + antigen-presenting cells (16). The observable effect of these manipulations is the abrogation of T cell stimulation because of ineffective macrophage-T cell interaction. I subregion-specific antibodies have also been shown to exert profound effects on antigen-specific reactivity when administered in vivo, where results are again consistent with antibody-mediated interference with macrophage-dependent T cell antigen recognition. Previous work from this laboratory has revealed that Lyt-1 ÷ T cell responses to syngeneic tumor antigen, assayed either by tumor rejection (17) or by the expression of delayed type-hypersensitivity (DTH) 1 (18), are inhibited by the intravenous injection of anti-I-A alloantisera. Inhibition of D T H in a hapten model was shown to be specific for the I-A genotype of the hapten-coupled antigen-presenting
MAJOR FACTOR DETERMINING OUTCOME IN EXPERIMENTAL ANGIOGENESIS TRIALS. RUNNING TITLE: PREEXISTING COLLATERALS DETERMINE STUDY OUTCOME

Objectives: Despite numerous animal trials reporting that cell therapy promotes collateral flow, clinical trials have not convincingly shown benefit. Patient-related risk factors are often used to explain these discrepancies. However, during the course of our own angiogenesis studies using mice, we noted large anatomical variability in collateral vessels. The purpose of the present investigation was to define how important this factor might be in determining intervention outcomes. Methods: Hindlimb ischemia was induced in BalbC mice by ligating the superficial femoral artery. After 24h, animals were treated by injecting the adductor muscle with either control media or cultured mesenchymal stem cells (MSCs). Blood flow recovery was measured using laser Doppler (LDPI-ratio). In a second experiment, mice were stratified 24h after arterial ligation prior to treatment using a simple clinical score of the ligated leg: 1: able to flex, mild discoloration; 2: no flexion, mild discoloration; 3: severe discoloration; 4: any necrosis. Results: Without stratification, blood flow recovery significantly increased in the MSC treated group (p<0.05, n=6 MSC group, n=7 media group). In the experiment employing stratification, all differences between the groups disappeared (n=11 MSC group, n=10 media group; p=0.3). Furthermore, we found a striking inverse correlation between clinical score on day 1 and the LDPI-ratio on day 28 (p<0.0001; n=79). Anatomic confirmation of the disparity in preexisting collaterals was found in two different mouse strains using micro-CT. Conclusions: There is substantial inter-animal variability in preexisting collateral flow, and this variability can importantly influence outcome. To Page 2 of 28 Copyright Information
ArticleThe Coal

The United Nations’ Sustainable Development Goal (SDG) number seven expressly calls for universal access to affordable and sustainable energy. Energy sustainability will require a reduction in energy consumption, including embedded energy consumption in sectoral demand and supply chains. However, few studies have estimated the amount of coal, petroleum, and gas (fossil fuel) embedded in demand-and-supply chains (FFEDS). Furthermore, the inter-and intra-sectoral energy linkages are understudied. This study quantifies China’s FFEDS, the world’s largest energy consumer. According to the findings, the highest levels of coal, natural gas, and petroleum consumption (CNGPC) are embedded in the construction sector’s input demand. “Electricity and steam production and supply” total intermediate exports (internal plus inter-sectoral) stimulated the highest coal consumption. “Crude petroleum products and natural gas products” and “railway freight transport” aggregate supplies induced the highest volume of natural gas and petroleum consumption. Compared to intra-sectoral demand, inter-sectoral demand stimulated significantly larger CNGPCs. In contrast, CNGPC’s interand inter-sectoral supplies were nearly identical. Modifying current carbon taxation and credit mechanisms to include energy embedded in demand and supply can help to achieve SDG 7.
INFLUENCE ON BEARING PRESSURE OF SHALLOW FOOTING RESTING ON GEOGRID REINFORCED DOUBLE LAYERED SOIL SYSTEM

Model test was conducted to investigate the effect of geogrid reinforcement on bearing pressure of strip footing resting on sand overlay on clayey soil stabilized with fly ash. Various percentages of fly ash mixed with clayey soil and found the optimum proportion. The optimum percentage of fly ash mixed with clay and then used as a second layer in the model test. Experiments were conducted on model test of strip footing, calculated the bearing pressure of double layer soil system without geogrid, with geogrid at the interface level and at designated levels within the sand layer. To check the different parameters contributing to their performance using model test of tank size is 830mm x 680mm x 630mm. The parameters investigated in this study include H/W (thickness of top sandy layer to width of footing), x/W (depth of the 1st layer of geogrid to width of footing), d/W (spacing between consecutive geogrid layers to width of footing), l/W (length of the geogrid layer to width of footing). The effect of different H/W ratios and no. of geogrid layers (n) on the bearing pressure ratio (BPR) and settlement reduction ratio (SRR) were investigated. Based on the Atterberg’s limit the optimum mix obtained is 90% clay and 10% fly ash. The optimum mix was used as bottom layer in the model tank. The result indicates that bearing pressure increases with increasing the H/W ratio and n values. The bearing pressure calculated without geogrid at three different materials like clay alone, optimum mix of clay and fly ash and double layers (sand, optimum mix of clay and fly ash) are 104.1, 106.8 and 187.5 kN/m respectively. Geogrid reinforcement used at the interface (n=1) and at two different levels within sand layer (n=2, 3), the corresponding bearing pressure values are 270 kN/m, 315 kN/m and 636.7 kN/m respectively. The bearing pressure for the soil increases with H/W = 0.5, 1, 1.5 and 2, the average values are 12.35%, 35.76%, 75.56% and 230.83% respectively. It was found that the use of geogrid at interface and multiple layers has a considerable effect on the bearing pressure. Use of geogrid layers in the granular overlay has significant effect on Bearing pressure ratio (BPR) & Settlement reduction ratio (SRR).
Agalsidase alfa (ReplagalTM) in the treatment of Anderson-Fabry disease

Correspondence: Gregory M Pastores Neurogenetics Division, Department of Neurology and Pediatrics, New York University School of Medicine, New York, NY 10016, USA Email gregory.pastores@nyumc.org Abstract: Anderson-Fabry disease (AFD) is an X-linked storage disorder caused by a defi ciency of the lysosomal hydrolase a-galactosidase A (AGAL) and the resultant accumulation of its glycosphingolipid substrate (Gb3) in several tissue types. Major morbidity and reduced life expectancy among affected individuals are a consequence of renal, cardiac and cerebrovascular involvement. Symptomatic males and females with AFD have been described, although the onset of clinical manifestations may be delayed and more variable among the latter patient group, partly attributed to lyonization. Agalsidase alfa (Replagal) is a recombinant formulation of human AGAL which has been demonstrated to modify the course of AFD in treated patients. Factors that may infl uence clinical outcomes include disease stage at the point of treatment initiation and antibody formation. There is incomplete understanding of AFD pathophysiology. Early diagnosis and timely intervention may be essential. The use of adjunctive therapies, directed at risk reduction (eg, aspirin for stroke prophylaxis), require careful scrutiny, but such agents are likely to be vital components of a comprehensive approach to patient care. Long-term studies may clarify the optimal dose and frequency of enzyme administration. Meanwhile, budding strategies such as chaperone-mediated enzyme enhancement may offer the potential for an alternative or multimodality approach to the management of AFD.
The differential role of a1- and a5-containing GABAA receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats

The clinical use of benzodiazepines (BZs) is hampered by sedation and cognitive deterioration. Although genetic and pharmacological studies suggest that a1and a5-containing GABAA receptors mediate and/or modulate these effects, their molecular substrate is not fully elucidated. By the use of two selective ligands : the a1-subunit affinity-selective antagonist b-CCt, and the a5-subunit affinityand efficacyselective antagonist XLi093, we examined the mechanisms of behavioural effects of diazepam in the tests of spontaneous locomotor activity and water-maze acquisition and recall, the two paradigms indicative of sedativeand cognition-impairing effects of BZs, respectively. The locomotor-activity decreasing propensity of diazepam (significant at 1.5 and 5 mg/kg) was antagonized by b-CCt (5 and 15 mg/kg), while it tended to be potentiated by XLi093 in doses of 10 mg/kg, and especially 20 mg/kg. Diazepam decreased acquisition and recall in the water maze, with a minimum effective dose of 1.5 mg/kg. Both antagonists reversed the thigmotaxis induced by 2 mg/kg diazepam throughout the test, suggesting that both GABAA receptor subtypes participate in BZ effects on the procedural component of the task. Diazepam-induced impairment in the declarative component of the task, as assessed by path efficiency, the latency and distance before finding the platform across acquisition trials, and also by the spatial parameters in the probe trial, was partially prevented by both, 15 mg/kg b-CCt and 10 mg/kg XLi093. Combining a BZ with b-CCt results in the near to control level of performance of a cognitive task, without sedation, and may be worth testing on human subjects. Received 9 October 2008 ; Reviewed 1 November 2008 ; Revised 20 January 2009 ; Accepted 23 January 2009 ; First published online 6 March 2009
Title: Meta-Analysis of Heifer Traits Identified Reproductive Pathways in Bos indicus Cattle -6pt

Fertility traits measured early in life define the reproductive potential of heifers. Knowledge of genetics and biology can help devise genomic selection methods to improve heifer fertility. In this study, we used ~2400 Brahman cattle to perform GWAS and multi-trait meta-analysis to determine genomic regions associated with heifer fertility. Heifer traits measured were pregnancy at first mating opportunity (PREG1, a binary trait), first conception score (FCS, score 1 to 3) and rebreeding score (REB, score 1 to 3.5). The heritability estimates were 0.17 (0.03) for PREG1, 0.11 (0.05) for FCS and 0.28 (0.05) for REB. The three traits were highly genetically correlated (0.75–0.83) as expected. Meta-analysis was performed using SNP effects estimated for each of the three traits, adjusted for standard error. We identified 1359 significant SNPs (p-value < 9.9 × 10−6 at FDR < 0.0001) in the multi-trait meta-analysis. Genomic regions of 0.5 Mb around each significant SNP from the meta-analysis were annotated to create a list of 2560 positional candidate genes. The most significant SNP was in the vicinity of a genomic region on chromosome 8, encompassing the genes SLC44A1, FSD1L, FKTN, TAL2 and TMEM38B. The genomic region in humans that contains homologs of these genes is associated with age at puberty in girls. Top significant SNPs pointed to additional fertilityrelated genes, again within a 0.5 Mb region, including ESR2, ITPR1, GNG2, RGS9BP, ANKRD27, TDRD12, GRM1, MTHFD1, PTGDR and NTNG1. Functional pathway enrichment analysis resulted in many positional candidate genes relating to known fertility pathways, including GnRH signaling, estrogen signaling, progesterone mediated oocyte maturation, cAMP signaling, calcium signaling, glutamatergic signaling, focal adhesion, PI3K-AKT signaling and ovarian steroidogenesis pathway. The comparison of results from this study with previous transcriptomics and proteomics studies on puberty of the same cattle breed (Brahman) but in a different population identified 392 genes in common from which some genes—BRAF, GABRA2, GABR1B, GAD1, FSHR, CNGA3, PDE10A, SNAP25, ESR2, GRIA2, ORAI1, EGFR, CHRNA5, VDAC2, ACVR2B, ORAI3, CYP11A1, GRIN2A, ATP2B3, CAMK2A, PLA2G, CAMK2D and MAPK3—are also part of the above-mentioned pathways. The biological functions of the positional candidate genes and their annotation to known pathways allowed integrating the results into a bigger picture of molecular mechanisms related to puberty in the hypothalamus–pituitary–ovarian axis. A reasonable number of genes, common between previous puberty studies and this study on early reproductive traits, corroborates the proposed molecular mechanisms. This study identified the polymorphism associated with early reproductive traits, and candidate genes that provided a visualization of the proposed mechanisms, coordinating the hypothalamic, pituitary, and ovarian functions for reproductive performance in Brahman cattle.