Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Supplementing Sea Buckthorn Leaves (Hippophae rhamnoides L.) and Chromium (III) in Broiler Diet on the Nutritional Quality and Lipid Oxidative Stability of Meat

Nowadays, the consumer trend towards healthier food choices is unquestionable. Meat products enriched with nutrients, such as polyunsaturated fatty acids and antioxidants, are gaining much more interest among consumers. However, products are susceptible to quality deterioration and a short shelf-life of meat through lipid oxidation due to the lack of antioxidants in the meat. In this regard, the efficacy of dietary sea buckthorn leaves (Hippophaë rhamnoides L.) together with Chromium on the nutritional quality of meat and lipid oxidative stability was investigated. An experiment (28 days long) was carried out on 90 Cobb 500 chickens assigned into three treatments: a control treatment based on corn and soybean meal, without Chromium (T0) and two treatments supplemented either with 0.00002% Chromium (T1) or with 0.00002% Chromium and 2% sea buckthorn leaves (T2). Dietary supplementation of SBL and Cr improved the PUFA/MUFA ratio, DHA concentration and decreased the n-6/n-3 ratio compared to the other treatments. Moreover, the breast and thigh meat belonging to T1 and T2 treatments showed a higher concentration of lutein and zeaxanthin, Fe and Zn and expressed a higher antioxidant capacity compared to those from T0. Furthermore, n-6 and n-3 PUFA deposited preferentially in the thigh meat rather than in the breast meat. The results from the study showed that dietary SBL and Cr significantly improved the fatty acid pattern and the oxidative stability of chicken breast meat, lowering the TBARS level after storage. In conclusion, SBL and Cr are promising dietary bioactive compounds with beneficial effects to obtain nutrient-enriched meat products.
Mitochondria-Targeted Human Catalase in the Mouse Longevity MCAT Model Mitigates Head-Tilt Bedrest-Induced Neuro-Inflammation in the Hippocampus

Microgravity (modeled by head-tilt bedrest and hind-limb unloading), experienced during prolonged spaceflight, results in neurological consequences, central nervous system (CNS) dysfunction, and potentially impairment during the performance of critical tasks. Similar pathologies are observed in bedrest, sedentary lifestyle, and muscle disuse on Earth. In our previous study, we saw that head-tilt bedrest together with social isolation upregulated the milieu of pro-inflammatory cytokines in the hippocampus and plasma. These changes were mitigated in a MCAT mouse model overexpressing human catalase in the mitochondria, pointing out the importance of ROS signaling in this stress response. Here, we used a head-tilt model in socially housed mice to tease out the effects of head-tilt bedrest without isolation. In order to find the underlying molecular mechanisms that provoked the cytokine response, we measured CD68, an indicator of microglial activation in the hippocampus, as well as changes in normal in-cage behavior. We hypothesized that hindlimb unloading (HU) will elicit microglial hippocampal activations, which will be mitigated in the MCAT ROS-quenching mice model. Indeed, we saw an elevation of the activated microglia CD68 marker following HU in the hippocampus, and this pathology was mitigated in MCAT mice. Additionally, we identified cytokines in the hippocampus, which had significant positive correlations with CD68 and negative correlations with exploratory behaviors, indicating a link between neuroinflammation and behavioral consequences. Unveiling a correlation between molecular and behavioral changes could reveal a biomarker indicative of these responses and could also result in a potential target for the treatment and prevention of cognitive changes following long space missions and/or muscle disuse on Earth.
Scalar FCNC and rare top decays in a two Higgs doublet model"for the top"

In the so called two Higgs doublet model for the top-quark (T2HDM), first suggested by Das and Kao, the top quark receives a special status, which endows it with a naturally large mass, and also potentially gives rise to large flavor changing neutral currents (FCNC) only in the up-quark sector. In this paper we calculate the branching ratio (BR) for the rare decays t → ch and h → t̄c (h is a neutral Higgs) in the T2HDM, at tree level and at 1-loop when it exceeds the tree-level. We compare our results to predictions from other versions of 2HDM’s and find that the scalar FCNC in the T2HDM can play a significant role in these decays. In particular, the 1-loop mediated decays can be significantly enhanced in the T2HDM compared to the 2HDM of types I and II, in some instances reaching BR ∼ 10−4 which is within the detectable level at the LHC.
Adenovirus-Inspired Virus-like-Particles Displaying Melanoma Tumor Antigen Specifically Target Human DC Subsets and Trigger Antigen-Specific Immune Responses

Virus-like particles constitute versatile vectors that can be used as vaccine platforms in many fields from infectiology and more recently to oncology. We previously designed non-infectious adenovirus-inspired 60-mer dodecahedric virus-like particles named ADDomers displaying on their surface either a short epitope or a large tumor/viral antigen. In this work, we explored for the first time the immunogenicity of ADDomers exhibiting melanoma-derived tumor antigen/epitope and their impact on the features of human dendritic cell (DC) subsets. We first demonstrated that ADDomers displaying tumor epitope/antigen elicit a strong immune-stimulating potential of human DC subsets (cDC2s, cDC1s, pDCs), which were able to internalize and cross-present tumor antigen, and subsequently cross-prime antigen-specific T-cell responses. To further limit off-target effects and enhance DC targeting, we engineered specific motifs to de-target epithelial cells and improve DCs’ addressing. The improved engineered platform making it possible to display large antigen represents a tool to overcome the barrier of immune allele restriction, broadening the immune response, and paving the way to its potential utilization in humans as an off-the-shelf vaccine.
The Sterile–Active Neutrino Flavor Model: The Imprint of Dark Matter on the Electron Neutrino Spectra

Contact interactions between sterile neutrinos and dark matter particles in a hidden sector have been suggested as a good solution to simultaneously resolve the dark matter problem and anomalies in neutrino experiments. In this non-standard particle physics model, sterile and active neutrinos change their flavor through vacuum oscillations and matter (or Mikheyev–Smirnov–Wolfenstein) oscillations, in which the latter mechanism of flavor oscillation depends strongly on the concentration of dark matter in the Sun’s core. We found that a large concentration of dark matter in the Sun’s interior changes substantially the shape of 8B and hep electron neutrino spectra, but has an insignificant impact on the other neutrino spectra (i.e., pp, pep, 7Be, 15O, 13N, and 17F). The strength of the interaction of the dark matter particles with neutrinos depends on an effective coupling constant, Gχ, which is an analog of the Fermi constant for the hidden sector. By using the latest data on the 8B solar neutrino flux, we found that Gχ must be smaller than 0.5 × 109 GF for this particle physics model to be in agreement with the data.
One-zone models for spheroidal galaxies with a central supermassive black-hole - Self-regulated Bondi accretion

By means of a one-zone evolutionary model, we study the co-evolution of supermassive black holes and their host galaxies, as a function of the accretion radiative efficiency, dark matter content, and cosmological infall of gas. In particular, the radiation feedback is computed by using the self-regulated Bondi accretion. The models are characterized by strong oscillations when the galaxy is in the AGN state with a high accretion luminosity. We found that these one-zone models are able to reproduce two important phases of galaxy evolution, namely an obscured-cold phase when the bulk of star formation and black hole accretion occur, and the following quiescent hot phase in which accretion remains highly sub-Eddington. A Compton-thick phase is also found in almost all models, associated with the cold phase. An exploration of the parameter space reveals that the closest agreement with the present-day Magorrian relation is obtained, independently of the dark matter halo mass, for galaxies with a low-mass seed black hole, and the accretion radiative efficiency � 0.1.
A Seroepidemiological Survey of Corynebacterium pseudotuberculosis Infection in South Tyrol, Italy

Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis, a bacterial infection that can affect livestock. This infection can cause low growth rates and milk yields and reproductive failure, along with the infection of humans, especially those in close contact with the animals. The aim of this study was to evaluate the local CLA prevalence, highlighting the parameters for the potential predisposition to infection in goats, and to implement a monitoring program based on the newly acquired scientific evidence. Of a total of 2365 goat farms in South Tyrol, 384 farms were selected for the present study. A statistically significant number of animals were subjected to serologic analysis for the detection of C. pseutotubercolosis antibodies. A total of 2948 goats belonging to the selected farms were tested for CLA, 713 of which showed a positive result. The data analysis led to an estimated CLA seroprevalence of 21.85%. The results achieved can enable the evaluation and possible implementation of a voluntary program that permits us to test a larger number of animals using serological techniques. This program would be of great importance, especially for those farms dedicated to the production of milk and dairy products, as some manufacturing practices may increase the risk of transmission of zoonotic pathogens such as C. pseudotuberculosis to humans.
The interstellar medium and star formation of galactic disks. I. Interstellar medium and giant molecular cloud properties with diffuse far-ultraviolet and cosmic-ray backgrounds

We present a series of adaptive mesh refinement (AMR) hydrodynamic simulations of flat rotation curve galactic gas disks with a detailed treatment of the interstellar medium (ISM) physics of the atomic to molecular phase transition under the influence of diffuse FUV radiation fields and cosmic ray backgrounds. We explore the effects of different FUV intensities, including a model with a radial gradient designed to mimic the Milky Way. The effects of cosmic rays, including radial gradients in their heating and ionization rates, are also explored. The final simulations in this series achieve $4\:$pc resolution across the $\sim20\:$kpc global disk diameter, with heating and cooling followed down to temperatures of $\sim10\:$K. The disks are evolved for $300\:$Myr, which is enough time for the ISM to achieve a quasi-statistical equilibrium. In particular, the mass fraction of molecular gas stabilizes by $\sim$200 Myr. Additional global ISM properties are analysed. Giant molecular clouds (GMCs) are also identified and the statistical properties of their populations examined. GMCs are tracked as the disks evolve. GMC collisions, which may be a means of triggering star cluster formation, are counted and the rates compared with analytic models. Relatively frequent GMC collision rates are seen in these simulations and their implications for understanding GMC properties, including the driving of internal turbulence, are discussed.
Unusual Localization of Hysterothylacium Incurvum in Xiphias gladius (Linnaeus 1758) Caught in the Atlantic Ocean

This study represents the first report of Hysterothylacium incurvum within swordfish (Xiphias gladius) heart chambers. Swordfish is a large pelagic teleost, considered one of the most appreciated fish worldwide. Among swordfish parasites, Anisakis sp. and Hysterothylacium sp. have been used to evaluate biological and ecological aspects of this teleost. Between 2021 and 2022, 364 X. gladius hearts, caught from the Atlantic Ocean (FAO 27.IXa and FAO 34 areas), were collected at the Milan fish market (Lombardy, Italy). Three specimens from FAO 27.IXa was positive for seven adult nematodes (p = 1.55%) within the heart chambers. Of these, three specimens were found within the bulbus arteriosus and 4 in the ventricle. All parasites were stored in 70% ethanol and processed for parasitological and molecular analysis using Cox2, ITS regions/ITS-I-5.8S-ITS-II, and rrnS genes. The analysis allowed us to identify the retrieved parasite as H. incurvum. According to our evaluation, the final localization is due to the movement of L3 larvae from the coelomic cavity to the bloodstream, with consequent development to the adult stage within the heart. Finally, the parasite localization, considered non-marketable fish parts, does not pose a significant risk to consumers, also considering the low zoonotic potential of H. incurvum.
Maternal Multiple Sclerosis and Offspring’s Cognitive and Behavioral Development: What Do We Know until Now?

Multiple Sclerosis (MS) is a chronic pathological condition representing one of the main causes of neurological disability in the female young population. MS, as an immune disorder, could impact fetus development, and, considering the need for and the possibility of pharmacological treatment during pregnancy, the possible influence of medication on developmental trajectories represents a topic of great interest. We provide an overview of the available literature on the influence of maternal Multiple Sclerosis on offspring cognitive and behavioral development. A study was conducted on Pubmed, Medline and Google Scholar, considering empirical studies and reviews exclusively in the English language. Maternal MS appears not to be associated with emotional and behavioral problems, as evaluated through retrospective studies. However, a specific cognitive and behavioral phenotype, through the administration of standardized instruments, has not been delineated yet. Available studies on the topic are characterized by poor methodology and do not lead to conclusions. This overview highlights implications for further longitudinal studies which should delineate offspring developmental trajectories, taking into consideration maternal confounding factors and the exposure to pharmacological treatment in pregnancy.
GRB 090727 AND GAMMA-RAY BURSTS WITH EARLY-TIME OPTICAL EMISSION

We present a multi-wavelength analysis of Swift gamma-ray burst GRB 090727, for which optical emission was detected during the prompt gamma-ray emission by the 2 m autonomous robotic Liverpool Telescope and subsequently monitored for a further two days with the Liverpool and Faulkes Telescopes. Within the context of the standard fireball model, we rule out a reverse shock origin for the early-time optical emission in GRB 090727 and instead conclude that the early-time optical flash likely corresponds to emission from an internal dissipation process. Putting GRB 090727 into a broader observational and theoretical context, we build a sample of 36 gamma-ray bursts (GRBs) with contemporaneous early-time optical and gamma-ray detections. From these GRBs, we extract a sub-sample of 18 GRBs, which show optical peaks during prompt gamma-ray emission, and perform detailed temporal and spectral analysis in gamma-ray, X-ray, and optical bands. We find that in most cases early-time optical emission shows sharp and steep behavior, and notice a rich diversity of spectral properties. Using a simple internal shock dissipation model, we show that the emission during prompt GRB phase can occur at very different frequencies via synchrotron radiation. Based on the results obtained from observations and simulation, we conclude that the standard external shock interpretation for early-time optical emission is disfavored in most cases due to sharp peaks (Δt/t < 1) and steep rise/decay indices, and that internal dissipation can explain the properties of GRBs with optical peaks during gamma-ray emission.
Therapeutic response to bronchial thermoplasty - toward feasibility of patient selection based on modelling predictions.

Bronchial thermoplasty (BT) is a treatment for moderate-to-severe asthma in which the airway smooth muscle layer is targeted directly using thermal ablation. Although it has been shown to be safe and effective in long-term follow up, questions remain about its mechanism of action, patient selection, and optimization of protocol based on structural phenotype. Using a cohort of 20 subjects who underwent thermoplasty and assessment by computed tomography (CT), we demonstrate that response to BT can be feasibly predicted based on pre-treatment airway dimensions that inform a subject-specific computational model. Analysis revealed the need for CT assessment at total lung capacity, rather than functional residual capacity, which was less sensitive to the effects of BT. Final model predictions compared favorably with observed outcomes in terms of airway calibre and asthma control, suggesting that this approach could form the basis of improved clinical practice.
ENHANCED STAR FORMATION OF LESS MASSIVE GALAXIES IN A PROTOCLUSTER AT z = 2.5

We investigate a correlation between star formation rate (SFR) and stellar mass for Hα emission-line galaxies (HAEs) in one of the richest protoclusters ever known at z ∼ 2.5, the USS 1558-003 protocluster. This study is based on a 9.7 hr narrowband imaging data with MOIRCS on the Subaru telescope. We are able to construct a sample in combination with additional H-band data taken with WFC3 on the Hubble Space Telescope, of 100 HAEs reaching the dust-corrected SFRs down to 3 M⊙ yr−1 and the stellar masses down to 108.0 M⊙. We find that while the star-forming galaxies with ≳109.3 M⊙ are located on the universal SFR-mass main sequence (MS) irrespective of the environment, less massive star-forming galaxies with ≲109.3 M⊙ show a significant upward scatter from the MS in this protocluster. This suggests that some less massive galaxies are in a starburst phase, although we do not know yet if this is due to environmental effects.
On the nature of star-forming filaments – I. Filament morphologies

We use a suite of high resolution molecular cloud simulations carried out with the moving mesh code Arepo to explore the nature of star-forming filaments. The simulated filaments are identified and categorised from column density maps in the same manner as for recent Herschel observations. When fit with a Plummer-like profile the filaments are in excellent agreement with observations, and have shallow power-law profiles of p~2.2 without the need for magnetic support. When data within 1 pc of the filament centre is fitted with a Gaussian function, the average FWHM is ~0.3 pc, in agreement with predictions for accreting filaments. However, if the fit is constructed using only the inner regions, as in Herschel observations, the resulting FWHM is only ~0.2 pc. This value is larger than that measured in IC 5146 and Taurus, but is similar to that found in the Planck Galactic Cold Cores and in Cygnus X. The simulated filaments have a range of widths rather than a constant value. When the column density maps are compared to the 3D gas densities, the filaments seen in column density do not belong to a single structure. Instead, they are made up of a network of short ribbon-like sub-filaments reminiscent of those seen in Taurus. The sub-filaments are pre-existing within the simulated clouds, have radii similar to their Jeans radius, and are not primarily formed through fragmentation of the larger filament seen in column density. Instead, small filamentary clumps are swept together into a single column density structure by the large-scale collapse of the cloud.
Scalar field perturbations in Hořava-Lifshitz cosmology

We study perturbations of a scalar field cosmology in Hořava-Lifshitz gravity, adopting the most general setup without detailed balance but with the projectability condition. We derive the generalized Klein-Gordon equation, which is sixth-order in spatial derivatives. Then we investigate scalar field perturbations coupled to gravity in a flat Friedmann-Robertson-Walker background. In the sub-horizon regime, the metric and scalar field modes have independent oscillations with different frequencies and phases except in particular cases. On super-horizon scales, the perturbations become adiabatic during slow-roll inflation driven by a single field, and the comoving curvature perturbation is constant.
Sociality, ecology and developmental constraints predict variation in brain size across birds

Conflicting theories have been proposed to explain variation in relative brain size across the animal kingdom. Ecological theories argue that the cognitive demands of seasonal or unpredictable environments have selected for increases in relative brain size, whereas the ‘social brain hypothesis’ argues that social complexity is the primary driver of brain size evolution. Here, we use a comparative approach to test the relative importance of ecology (diet, foraging niche and migration), sociality (social bond, cooperative breeding and territoriality) and developmental mode in shaping brain size across 1886 bird species. Across all birds, we find a highly significant effect of developmental mode and foraging niche on brain size, suggesting that developmental constraints and selection for complex motor skills whilst foraging generally imposes important selection on brain size in birds. We also find effects of social bonding and territoriality on brain size, but the direction of these effects do not support the social brain hypothesis. At the same time, we find extensive heterogeneity among major avian clades in the relative importance of different variables, implying that the significance of particular ecological and social factors for driving brain size evolution is often clade‐ and context‐specific. Overall, our results reveal the important and complex ways in which ecological and social selection pressures and developmental constraints shape brain size evolution across birds.
Association between Dietary Carbohydrate Intake and Control of Blood Pressure in Patients with Essential Hypertension

Background: Both high and low percentages of carbohydrate diets were associated with increased mortality and new-onset hypertension. However, few studies have aggregated to explore the association between carbohydrate intake and blood pressure (BP) control in patients with hypertension. This study aimed to explore the association between carbohydrate-to-energy proportion (CEP) and the rate of poorly controlled BP in patients with hypertension. Methods: A cross-sectional survey was conducted in one comprehensive hospital and one community clinic in China. Dietary CEP was obtained through two-24 h dietary recalls. According to the quintiles of CEP, the participants were divided into Q1–Q5 groups. The average of two BP values was adopted as the final BP value, and poorly controlled BP was defined as systolic BP (SBP) ≥140 mmHg and/or diastolic BP (DBP) ≥ 90 mmHg. Results: A total of 459 hypertensive patients were recruited. In univariate analyses, CEP was associated with the control of SBP and DBP. After the covariates were adjusted for, fewer CEPs in Q1 (OR, 4.335; 95% CI, 1.663, 11.299) and Q2 (OR, 2.482; 95% CI, 1.234, 4.989) were significantly associated with higher rates of poor SBP control. Conclusions: A lower dietary CEP is a risk factor for SBP control, whereas an appropriate CEP of 56% to 66% is beneficial for BP control in patients with essential hypertension.