Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward Designing a Model of Professional Skills for Iranian EFL Teachers

: Recently, with the growing interest in teachers’ professionalism, lots of scholars have focused on different aspects of professionalism in teaching. One of the main aspects of teachers’ professionalism, which is related to structural theory and competence-oriented perspective, is teachers’ professional skills which is considered as a dimension of effective teaching. This study aimed at developing a model of professional skills for Iranian EFL teachers. To this end, a qualitative design was used. For the purpose of data collection, individual and focus group interviews were conducted. The participants of the study consisted of 25 English as a Foreign Language (EFL) teachers who were teaching English at secondary level of high schools in Bandar Abbas, Iran. They were selected through purposive sampling because those teachers with more than ten years of teaching experience at secondary level of high schools were recruited in the study. To collect the data, first, the interviews were conducted. Then, the elicited responses were transcribed and codified according to Strauss and Corbin’s (1998) systematic steps of open, axial and selective coding. The findings revealed three major themes (interpersonal skills, principle skills, pedagogical skills), nine categories and twenty-seven subcategories. As an implication of the findings, EFL teachers are recommended to consider professional skills while teaching to improve their teaching as well as their students’ learning.
Pushing A Sled with Constant Resistance and Controlled Cadence Induces Lower Limb Musculature Quicker Activation Response and Prolongs Duration with Faster Speed

Physical inactivity is rising in both youthful and older people. Such inactivity is problematic for many reasons, primarily because it contributes to overall physical deconditioning. This study examines characteristics in lower extremity muscle adaptations while pushing a sled at constant resistance with three varying cadences. Twenty-one graduate school participants with an average age of 22.8 years consented to place electromyography (EMG) electrodes on their dominant leg. The targeted muscles for the EMG electrodes were over the gastrocnemius (GA), tibialis anterior (TA), and gluteus maximus (GMax). The subject's muscle activation was monitored over three different walking protocols at varying cadences. The protocols were: slow walk (SW, 80 bpm), intermediate walk (IW, 110 bpm), and fast walk cadence (FW, 140 bpm). The investigation results portrayed two main findings: the muscles studied exhibited faster muscle recruitment and a shorter duration of activation when cadence was increased from the IW to the FW cadence. The second discovery among the IW and FW protocols revealed that the GA and Gmax showed greater muscular adaptations than the TA. In conclusion, pushing the sled proves effective in recruiting lower extremity musculature, indicating it could be of great use in rehabilitating individuals deemed deconditioned.
Pengungkapan Corporate Social Responsibility Selama Pandemi COVID-19 di Indonesia

This study aims to look at the differences and patterns of Corporate Social Responsibility (CSR) disclosure before and during the Covid-19 pandemic. The sample in this study consisted of 156 manufacturing companies listed on the Indonesia Stock Exchange year 2019 and 2020. This research is a quantitative research using comparative analysis and content analysis as an analysis tool. The results showed significant differences in CSR disclosure before and during the Covid-19 pandemic. CSR disclosure during the Covid-19 pandemic has decreased compared to CSR disclosure before the Covid-19 pandemic. However, economic performance indicators have increased. This pattern is in line with the stakeholder theory, which states that in times of uncertainty such as economic and financial crises, companies tend to focus on fulfilling the interests of their definitive stakeholders, which are investors and creditors.
Indirect ELISA as a complementary diagnostic method of bovine tuberculosis

ABSTRACT: Bovine tuberculosis is an economic and health problem, requiring precise diagnostic methods for its control and eradication. The aim of this study was to evaluate the performance of a commercial enzyme-linked immunosorbent assay (ELISA) test for the diagnosis of bovine tuberculosis. A total of 1,644 cattle from eight dairy herds were evaluated using the comparative cervical tuberculin test (CCTT). Three of the herds had no recent tuberculosis infection, and the other five had shown positive results in a previous tuberculin test. For the serological diagnosis of tuberculosis, a commercial ELISA antibody test kit for Mycobacterium bovis was used. Serum samples from 846 cattle from the eight herds were evaluated using ELISA for M. bovis. Animals that were positive based on either CCTT or ELISA for M. bovis or both were sent to slaughter. Samples of their lungs, livers, and lymph nodes were collected and stored under refrigeration for microbiological culture and subsequent confirmation by polymerase chain reaction. Samples from the same tissues were also fixed with 10% formaldehyde in bottles for histopathological examination and stained with hematoxylin and eosin (HE). Of the 1,644 cattle, 61 were considered positive and 65 inconclusive based on CCTT. Retesting of the inconclusive samples identified an additional 19 positive cases, totaling 80 (4.8%) CCTT-positive animals from five herds. ELISA for M. bovis identified 4.2% (36/846) positive cattle, of which 35 were considered negative and one inconclusive based on CCTT. Of the 36 positive cases identified by ELISA for M. bovis, 27 were euthanized, 11% (3/27) showed suggestive lesions of tuberculosis on macroscopic examination, and two were confirmed by histological, microbiological, and PCR methods. The weak association of ELISA for M. bovis with the results obtained by macroscopic, histological, and microbiological isolation indicates the fragility of ELISA performance in field conditions. Therefore, it is suggested that its use as a complementary method for herd sanitation be based on the local epidemiological situation.
Apathy Reflects Extra-Striatal Dopaminergic Degeneration in de novo Parkinson's Disease.

BACKGROUND Apathy represents a core neuropsychiatric symptom in Parkinson's disease (PD). As there is currently no established effective treatment for apathy in PD, further investigating the biological origin of this symptom is needed to design novel therapeutic strategies. Among the multiple neurotransmitter alterations that have been associated with apathy, the involvement of extra-striatal dopaminergic degeneration remains to be fully explored. OBJECTIVE To investigate whether apathy in PD reflects increased dopaminergic degeneration extending beyond striatal regions. METHODS In the de novo PD cohort of the Parkinson's Progression Markers Initiative (PPMI), we performed whole-brain I123-Ioflupane Single Photon Emission Computed Tomography (DAT-SPECT) analyses to characterize cross-sectional and longitudinal differences in DAT uptake associated with the presence of apathy. We also assessed the relationship between apathy and cognition in this sample, as apathy has been suggested to herald cognitive decline. RESULTS Apathetic PD patients (N = 70) had similar sociodemographic, clinical, and biomarker profiles compared to the non-apathetic group (N = 333) at baseline. However, apathy was associated with an increased risk of developing cognitive impairment after a four-year follow-up period (p = 0.006). Compared to non-apathetic patients, apathetic patients showed a widespread reduction of extra-striatal DAT uptake at baseline as well as an increased longitudinal loss of DAT uptake (corrected p < 0.05). CONCLUSIONS Isolated apathy in PD is associated with extra-striatal dopaminergic degeneration. As this abnormal dopamine depletion was in turn related to cognitive performance, this might explain, at least partially, the increased risk of apathetic PD patients to develop cognitive impairment or dementia.
Diagnostic Accuracy of Ischemia-Modified Albumin for Acute Coronary Syndrome: A Systematic Review and Meta-Analysis

The diagnostic usefulness of ischemia-modified albumin in acute coronary syndrome (ACS) has been questioned. The goal of this systematic review and meta-analysis was to see how accurate ischemia-modified albumin (IMA) was in diagnosing ACS in patients admitted to emergency departments (EDs). We searched for relevant literature in databases such as MEDLINE, EMBASE, and the Cochrane Library. Primary studies that reliably reported on patients with symptoms suggestive of ACS and evaluated IMA on admission to emergency departments were included. The QUADAS-2 tool was used to assess the risk of bias in the included research. A total of 4,761 patients from 19 studies were included in this systematic review. The sensitivity and specificity were 0.74 and 0.40, respectively, when the data were pooled. The area under the curve value for IMA for the diagnosis of ACS was 0.75, and the pooled diagnostic odds ratio value was 3.72. Furthermore, ACS patients with unstable angina had greater serum IMA levels than those with non-ischemic chest pain. In contrast to prior meta-analyses, our findings suggest that determining whether serum IMA levels are effective for diagnosing ACS in the emergency department is difficult. However, the accuracy of these findings cannot be ascertained due to high heterogeneity between studies.
Astragalus sinicus Incorporated as Green Manure for Weed Control in Corn

Astragalus sinicus L. (milk vetch), one of the most widespread green manure species, is widely planted in the temperate zone. Eleusine indica L. (goosegrass), a serious annual weed in the world, has evolved resistance to some non-selective herbicides. The use of milk vetch as green manure for weed control in paddy fields was proposed. Aqueous extracts of milk vetch are known to exert a different level of phytotoxicity on weeds and crops. Phytotoxic substances contained in green manure were released into the soil by leaching at the initial stage and decomposition at the later stage after the return of green manure. Considering the need for searching new sustainable strategies for weed control, a question arises: “if milk vetch could be applied in goosegrass control, which stage is the most important to control goosegrass after milk vetch returned to the field, and at the same time, will the subsequent crop, corn (Zea mays L.), be affected by the side effects from milk vetch phytotoxicity? ” In this study, the potential of milk vetch for goosegrass control was approached by repeated laboratory experiments, which include the aqueous extract experiment, decomposed experiment, and pot experiment. The effects of milk vetch returning to the field on maize were simulated by a pot experiment. The extract of milk vetch could significantly inhibit the germination of goosegrass at 2% concentration, and the inhibition enhanced with the increase of concentration. In the decomposed liquid experiment, decay time within 15 days, with the increase of decay days or concentration, goosegrass inhibition effect of decomposed liquid was enhanced. When decay time was more than 15 days, the inhibition ability of the decomposed liquid to goosegrass decreased. According to the RI accumulated value, aqueous extract and decomposed liquid have a “hormesis effect” on the germination and growth of goosegrass. Pot experiment proved that the addition of 1–10% (w/w) of milk vetch significantly reduced the germination and growth of goosegrass. On the contrary, the comprehensive analysis showed that the participation of milk vetch was conducive to the growth of corn. Our results constitute evidence that the incorporation of milk vetch into the soil could be a feasible practice to reduce weed infarctions in the corn-based cropping system.
National Literacy Strategy: Review of research and other related evidence

The National Literacy Strategy provides steady and consistent means of raising standards of literacy in England over a long period of time. The Strategy is made up of a Framework for Teaching, which gives detailed guidance to teachers, a supporting professional development program, and other community-based elements. This Review of Research indicates many of the sources of research and related evidence which underpin the National Literacy Strategy. In particular, the Review concentrates on the Framework for Teaching, but it also draws upon sources related to the Policy and Strategic Justifications, School Effectiveness, and Management and Issues of Teaching Quality. These sources include findings from survey, experimental, and observational research; analyses and discussions from literary scholarship; and reports from curriculum development projects and school inspections. Of particular value have been a number of meta-analyses of research in a particular field, and these serve as landmarks at several points in the Review. Although the length of the review was limited, and work in preparing it has inevitably had to be of a selective nature, where appropriate, every effort has been made to refer to sources which identify overviews of relevant evidence. Includes an extensive bibliography. Appended is information about recurring issues in inspection evidence.
NK1 receptor antagonists versus other antiemetics in the prevention of postoperative nausea and vomiting following laparoscopic surgical procedures: a systematic review and meta-analysis

A systematic electronic search of MEDLINE, EMBASE, and CINAHL databases aimed at comparing neurokinin-1 receptor antagonists with other antiemetics in their prevention of postoperative nausea and vomiting in adult patients undergoing laparoscopic surgery identified seven randomized controlled trials for review and meta-analysis. Preoperative aprepitant 80 mg was found to reduce nausea (RR: 0.56, 95% CI: 0.41–0.75, I2 = 0%, P = 0.89) and vomiting (RR: 0.20, 95% CI: 0.05–0.77, I2 = 0%, P = 0.96) and resulted in complete response (RR: 1.61 (1.25-2.08), I2 = 0%, P = 0.70) within the first 2 hours following surgery as well as vomiting in 2–24 hours (RR: 0.09, 95% CI: 0.02-0.36, I2 = 0%; P = 0.81) when compared to placebo or no antiemetic therapy. Preoperative aprepitant 80 mg has a superior overall effect compared to placebo or other antiemetics in the first two hours postoperatively, and thereafter reduces the risk of vomiting alone in the first 24 hours following laparoscopic surgeries.
Histologic and Molecular Patterns in Responders and Non-responders With Chronic-Active Antibody-Mediated Rejection in Kidney Transplants

Introduction There is no proven therapy for chronic-active antibody-mediated rejection (caABMR), the major cause of late kidney allograft failure. Histological and molecular patterns associated with possible therapy responsiveness are not known. Methods Based on rigorous selection criteria this single center, retrospective study identified 16 out of 1027 consecutive kidney transplant biopsies taken between 2008 and 2016 with pure, unquestionable caABMR, without other pathologic features. The change in estimated GFR pre- and post-biopsy/treatment were utilized to differentiate subjects into responders and non-responders. Gene sets reflecting active immune processes of caABMR were defined a priori, including endothelial, inflammatory, cellular, interferon gamma (IFNg) and calcineurin inhibitor (CNI) related-genes based on the literature. Transcript measurements were performed in RNA extracted from stored, formalin-fixed, paraffin-embedded (FFPE) samples using NanoString™ technology. Histology and gene expression patterns of responders and non-responders were compared. Results A reductionist approach applying very tight criteria to identify caABMR and treatment response excluded the vast majority of clinical ABMR cases. Only 16 out of 139 cases with a written diagnosis of chronic rejection fulfilled the caABMR criteria. Histological associations with therapy response included a lower peritubular capillaritis score (p = 0.028) along with less glomerulitis. In contrast, no single gene discriminated responders from non-responders. Activated genes associated with NK cells and endothelial cells suggested lack of treatment response. Conclusion In caABMR active microvascular injury, in particular peritubular capillaritis, differentiates treatment responders from non-responders. Transcriptome changes in NK cell and endothelial cell associated genes may further help to identify treatment response. Future prospective studies will be needed which include more subjects, who receive standardized treatment protocols to identify biomarkers for treatment response. Clinical Trial Registration [ClinicalTrials.gov], identifier [NCT03430414].
Patient satisfaction with anaesthesia services in a tertiary care cancer centre. (SAY study)

Background and Aims: Patient satisfaction is an important measure of quality of health care. Its assessment leads to a balanced evaluation of the structure, process and outcome of service at an institution. The aim of our study was to assess patient satisfaction with perioperative anaesthesia services provided in our institution and identify factors leading to dissatisfaction which could be preventable or addressed to improve patient care and experience. Material and Methods: A convenient sample size of 200 patients was accrued after written informed consent. A questionnaire to suit local needs of institute was developed, validated and a language appropriate questionnaire was administered by a trained research nurse 24–48 hours post anaesthesia to accrued patients. Data was summarised in percentages and satisfaction scores were compared across demographic variables using Chi square test. Results: A total of 96% (192/200) patients were satisfied with the overall interaction with the anaesthetists in the perioperative period; with 99% (198/200) patients being satisfied with acute pain services provided, postoperatively. As regards to recovery room, 96.5% (193/200) patients were satisfied with the services provided. Satisfaction scores of the pre-anaesthetic clinic (PAC), pain team and anaesthesia services compared across demographic variables – age, gender and education qualifications were found to be statistically non-significant. Conclusion: High rate of patients were satisfied with perioperative anaesthesia care services at our institute. Good and effective preoperative communication with the patient, effective management of postoperative pain and complications significantly contributed towards overall high patient satisfaction.
Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties

In mammalian cells, telomerase transcribes telomeres in large G-rich non-coding RNA, known as telomeric repeat-containing RNA (TERRA), which folds into noncanonical nucleic acid secondary structures called G-quadruplexes (G4s). Since TERRA G4 has been shown to be involved in telomere length and translation regulation, it could provide valuable insight into fundamental biological processes, such as cancer growth, and TERRA G4 binders could represent an innovative strategy for cancer treatment. In this work, the three best candidates identified in our previous virtual screening campaign on bimolecular DNA/RNA G4s were investigated on the monomolecular Tel DNA and TERRA G4s by means of molecular modelling simulations and in vitro and in cell analysis. The results obtained in this work highlighted the stabilizing power of all the three candidates on TERRA G4. In particular, the two compounds characterized by a chromene scaffold were selective TERRA G4 binders, while the compound with a naphthyridine core acted as a dual Tel/TERRA G4-binder. A biophysical investigation by circular dichroism confirmed the relative stabilization efficiency of the compounds towards TERRA and Tel G4s. The TERRA G4 stabilizing hits showed good antiproliferative activity against colorectal and lung adenocarcinoma cell lines. Lead optimization to increase TERRA G4 stabilization may provide new powerful tools against cancer.
Impact of Intercalated Degree on Post-graduate Career Progression and Academic Development in the UK: A Rapid Review of the Literature

An intercalated degree offers medical students an avenue to explore their interests and become competent in scientific literacy. Although intercalating can pose a financial burden and time commitment, they do provide competitive academic and speciality training applications. The aim of this review was to explore academic development and subsequent outcomes of career progression. Medline and EMBASE were systematically searched using keywords. After the removal of duplicates, the studies were screened against the inclusion criteria. For the five studies included in this review, a narrative synthesis was performed. The two main themes were academic development and career progression. All studies showed a plethora of academic achievements during and after intercalation. Two studies showed that students are more likely to enter a career in academic medicine. A further two studies have shown that the transferable skills of academia have allowed alumni to make more competitive applications for foundation year and speciality training. The results have shown a correlation between academic achievements and an increase in competitiveness in foundation programmes and speciality applications. There are clear discrepancies in the success of academic careers depending on the institution and type of intercalated degree. Current literature suggests a master’s degree results in more academic success compared to a bachelor’s degree. Due to the sheer diversity of intercalated degrees offered to medical students in the UK, there is limited literature on post-graduate career progression. More research should be undertaken to look at the implications of intercalation on post-graduate career progression.
Rapid Reduction Dimensionality Transfer Alignment Method Based on CKF for SINS of Ship-borne Aircraft with GNSS Assistance

Aiming at the problem of rapid transfer alignment of inertial navigation system in shipborne environment with large azimuth misalignment angle, a dimension reduction fast transfer alignment scheme of shipborne aircraft inertial navigation system based on CKF algorithm is designed. Firstly, the nonlinear attitude error equation, velocity error equation and position error equation of the Global Navigation Satellite System (GNSS) assisted strapdown inertial navigation system in the case of large azimuth misalignment are analyzed. Secondly, the nonlinear dimensionality reduction rapid transfer alignment state equation and measurement equation are derived. Finally, the CKF algorithm is simulated and verified, and compared with EKF algorithm and UKF algorithm. The simulation results show that the reduced dimension fast transfer alignment method of shipborne aircraft inertial navigation system based on CKF algorithm can complete the estimation of attitude error angle in 80s, with horizontal estimation error of 1’ and azimuth error of 4’, and the estimation accuracy is equivalent to EKF and UKF, with less calculation and better rapidity.
Co-agency: reconsidering agency in guidance practice

ABSTRACT This article contributes a social justice perspective to the ongoing discussions about the concepts that inform career guidance theory and practice. Due to the field’s psychological tradition, career guidance practices often adopt highly individualised notions of agency that fail to grasp the contextual factors and societal structures from which agency emerges. In this article an alternative approach to agency is offered by repositioning agency as a relational phenomenon. First, based on the findings of an ethnography that focuses on career guidance for youth in the margins of education and work, I explore how agency emerges as a relational and joint construction. A concept of co-agency is elaborated to express the embedded, co-constructed and political nature of agency.