Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiparameter operators and sharp weighted inequalities

This article is concerned with the operators from harmonic analysis which are naturally associated to a multiple parameter family of dilations. We are especially interested here in dealing with questions from the theory of such operators whose answers cannot be obtained by a reduction to the case of product operators. We also introduce a new tool in order to carry out this multiparameter analysis which comes from the classical theory. This is the concept of "sharp weighted inequalities," where, for operators such as the Hilbert transform or classical square function, one asks for Hilbert space inequalities which imply the correct estimates of the norm on LP of these operators as P becomes large. 0. Introduction. In this article, our main goal is to study classes of oper ators associated with multiparameter groups of dilations on Rn. In some sense the consideration of these operators is a natural "next step" or simplest case after those of the classical Calderon-Zygmund theory, and the product space theory. It turns out that in order to obtain estimates for the multiparameter operators we shall be led to the following type of extremely classical question: How does one obtain L2 estimates on R1 for the Hilbert transform (or other singular integrals) which yield sharp estimates on the LP(Rl) operator norm of H as p approaches 1 (or oc)? These "sharp weighted inequalities" are of some independent interest, and their study will be seen to be essentially equivalent to the deep work of Chang, Wilson, and Wolff (3) on the exponential square integrability of functions whose area integral is bounded. They also have other applications; for example, they provide an immediate extension of the Chang-Wilson-Wolff estimates to product spaces as given by Pipher in (12). At this point, let us be more specific about the exact nature of the multipa rameter operators which we shall consider. Consider, in R3, the dilations given by ps,t(x, y, z) = (sx, ty9 stz), for s91 > 0. Then there is a maximal operator (first considered by Zygmund) Ml and singular integrals Tl (introduced by Ricci and Stein (13)) naturally associated to these dilations. The maximal operator Af3 is defined by
The random minimal spanning tree in high dimensions

For the minimal spanning tree on n independent uniform points in the d-dimensional unit cube, the proportionate number of points of degree k is known to converge to a limit a k,d as n → ∞. We show that a k,d converges to a limit α k as d → ∞ for each k. The limit α k arose in earlier work by Aldous, as the asymptotic proportionate number of vertices of degree k in the minimum-weight spanning tree on k vertices, when the edge weights are taken to be independent, identically distributed random variables. We give a graphical alternative to Aldous's characterization of the α k .
Arsenic Trioxide Triggers Apoptosis of Metastatic Oral Squamous Cells Carcinoma with Concomitant Downregulation of GLI1 in Hedgehog Signaling

Given the lack of advances in Oral Squamous Cell Carcinoma (OSCC) therapy in recent years, pharmacological strategies to block OSCC-related signaling pathways have gained prominence. The present study aimed to evaluate the therapeutic potential of Arsenic Trioxide (ATO) concerning its antitumoral effects and the inhibition of the Hedgehog (HH) pathway in OSCC. Initially, ATO cytotoxicity was assessed in a panel of cell lines. Cell viability, cell cycle, death patterns, and cell morphology were analyzed, as well as the effect of ATO on the expression of HH pathway components. After the cytotoxic assay, HSC3 cells were chosen for all in vitro assays. ATO increased apoptotic cell death and nuclear fragmentation in the sub-G1 cell cycle phase and promoted changes in cell morphology. In addition, the reduced expression of GLI1 indicated that ATO inhibits HH activity. The present study provides evidence of ATO as an effective cytotoxic drug for oral cancer treatment in vitro.
Q wave in paediatric myocarditis: an underinvestigated, readily available prognostic factor

Abstract Background Myocarditis is an uncommon disease in children with potentially fatal consequences. An electrocardiogram (ECG) change seen in myocarditis is pathological Q wave. Pathological Q wave is linked to permanent damage and myocardial death in several cardiac diseases. We investigated the significance of pathological Q waves in children with acute myocarditis (AM). Methods This retrospective observational study analysed the data of 59 children with AM admitted to our hospital between January 2016 and July 2021. They were divided into Q wave and non-Q wave myocarditis groups. Patients’ laboratory data, echocardiography, treatment and hospital outcome were analysed. Results Patients were 64.4% male and had a median age of 6 years and 9 months. Pathological Q waves were found in 52.5% of the patients. Q wave myocarditis group had higher troponin I values (499 vs. 145 ng/L, p = 0.011) and longer hospital stays (13 vs. 9 days, p = 0.020) than the non-Q wave group. They also required higher doses of inotropic or vasoactive drugs. 61.3% of Q wave patients needed mechanical ventilation compared to 35.7% of non-Q wave patients (p = 0.069). All the patients who died or discharged with an LVEF < 30% belonged to the Q wave group. Conclusion Q wave in AM warrants close monitoring and intensive treatment as it accompanies more severe complications and poorer outcomes. This readily available ECG finding can be a clue to prognoses of AM patients. Further research with larger populations is needed to better understand Q wave prognostic accuracy and its potential role in guiding more expensive treatments.
A climatology of equatorial plasma bubbles from DMSP 1989–2004

After examining evening sector plasma density measurements from polar‐orbiting Defense Meteorological Satellite Program (DMSP) spacecraft for 1989–2004, we have established a statistical database of more than 14,400 equatorial plasma bubble (EPB) observations. EPBs are irregular plasma density depletions in the postsunset ionosphere that degrade communication and navigation signals. In general, the DMSP observations support Tsunoda's (1985) hypothesis that EPB rates peak when the terminator is aligned with the Earth's magnetic field, but unpredicted offsets are also evident in many longitude sectors. Plots of EPB rates for solar cycle phases: maximum 1989–1992 and 1999–2002, minimum 1994–1997, and transition years 1993, 1998, and 2003 reveal significant differences in the climatologies for solar maximum and minimum, between the two solar maxima, and in the transition years. To assess local time effects on EPB rates, we also compare observations from F12, F14, F15, and F16 at slightly different postsunset local times for 2000–2004. This study was undertaken to facilitate improvements in ionospheric models in preparation for the Communication/Navigation Outage Forecasting System (C/NOFS) mission.
Using a Nearest-Neighbour, BERT-Based Approach for Scalable Clone Detection

Code clones can detrimentally impact software maintenance and manually detecting them in very large code-bases is impractical. Additionally, automated approaches find detection of Type 3 and Type 4 (inexact) clones very challenging. While the most recent artificial deep neural networks (for ex-ample BERT-based artificial neural networks) seem to be highly effective in detecting such clones, their pairwise comparison of every code pair in the target system(s) is inefficient and scales poorly on large codebases.We therefore introduce SSCD, a BERT-based clone detection approach that targets high recall of Type 3 and Type 4 clones at scale (in line with our industrial partner’s requirements). It does so by computing a representative embedding for each code fragment and finding similar fragments using a nearest neighbour search. SSCD thus avoids the pairwise-comparison bottleneck of other Neural Network approaches while also using parallel, GPU-accelerated search to tackle scalability.This paper details the approach and an empirical assessment towards configuring and evaluating that approach in industrial setting. The configuration analysis suggests that shorter input lengths and text-only based neural network models demonstrate better efficiency in SSCD, while only slightly decreasing effectiveness. The evaluation results suggest that SSCD is more effective than state-of-the-art approaches like SAGA and SourcererCC. It is also highly efficient: in its optimal setting, SSCD effectively locates clones in the entire 320 million LOC BigCloneBench (a standard clone detection benchmark) in just under three hours.
Use of High-Resolution Satellite Observations to Evaluate Cloud and Precipitation Statistics from Cloud-Resolving Model Simulations. Part I: South China Sea Monsoon Experiment

Abstract Cloud and precipitation simulated using the three-dimensional (3D) Goddard Cumulus Ensemble (GCE) model are compared to Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI) and Precipitation Radar (PR) rainfall measurements and Clouds and the Earth’s Radiant Energy System (CERES) single scanner footprint (SSF) radiation and cloud retrievals. Both the model simulation and retrieved parameters are based upon observations made during the South China Sea Monsoon Experiment (SCSMEX) field campaign. The model-simulated cloud and rain systems are evaluated by systematically examining important parameters such as the surface rain rate, convective/stratiform percentage, rain profiles, cloud properties, and precipitation efficiency. It is demonstrated that the GCE model is capable of simulating major convective system development and reproduces the total surface rainfall amount as compared to rainfall estimated from the SCSMEX sounding network. The model yields a slightly higher total convecti.
Protective Efficacy of Inactivated H9N2 Vaccine in Turkey Poults under Both Experimental and Field Conditions

Low pathogenic avian influenza (LPAI) H9N2 virus is one of the major poultry pathogens associated with severe economic losses in the poultry industry (broiler, layers, breeders, and grandparents’ flocks), especially in endemic regions including the Middle East, North Africa, and Asian countries. This work is an attempt to evaluate the efficacy of whole inactivated H9N2 vaccine (MEFLUVACTM H9) in turkey poults kept under laboratory and commercial farm conditions. Here, 10,000 white turkey poults (1-day old) free from maternally derived immunity against H9N2 virus were divided into four groups; G1 involved 10 vaccinated birds kept under biosafety level-3 (BLS-3) as a laboratory vaccinated and challenged group, while G2 had 9970 vaccinated turkeys raised on a commercial farm. Ten of those birds were moved to BLS-3 for daily cloacal and tracheal swabbing to check for the absence of any life-threating disease, before conducting analyses. G3 (10 birds) served as a non-vaccinated challenged control under BSL-3 conditions, while G4 (10 birds) was used as a non-vaccinated and non-challenged control under BSL-3 conditions. Sera were collected on days 7-, 14-, 21-, and 28-post-vaccinations to monitor the humoral immune response using a hemagglutination-inhibition (HI) test. At these same intervals, cloacal and tracheal swabs were also checked for any viral infection. The challenge was conducted 28 days post-vaccination (PV) using AI-H9N2 in BSL-3 by intranasal inoculation of 6-log10 embryo infective dose50 (EID50). At 3-, 6-, and 10-days post-challenge, oropharyngeal swabs were taken from challenged birds to quantify viral shedding by quantitative polymerase chain reaction (qRT-PCR). The results of this study showed that vaccinated groups (G1/2) developed HI titers of 1.38, 4.38, 5.88, and 7.25 log2 in G1 vs. 1.2, 3.8, 4.9 and 6.2 log2 in G2 when measured at 7-, 14-, 21- and 28-days PV, respectively, while undetectable levels were recorded in non-vaccinated groups (G3/4). Birds in G3 showed 90% clinical sickness vs. 10% and 20% in G1/2, respectively, over a 10-day monitoring period following challenge. Vaccinated birds showed a significant reduction in virus shedding in terms of the number of shedders, amount of shed virus and shedding interval over the non-vaccinated challenged birds. Regarding mortality, all groups did not show any mortality, which confirms that the circulating H9N2 virus still has low pathogenicity and cannot cause mortality. However, the virus may cause up to 90% clinical sickness in non-vaccinated birds vs. 10% and 20% in laboratory- and farm-vaccinated birds, respectively, highlighting the role of the vaccine in limiting clinical sickness cases. In conclusion, under the current trial circumstances, MEFLUVACTM-H9 provided protective seroconversion titers, significant clinical sickness protection and significant reduction in virus shedding either in laboratory- or farm-vaccinated groups after a single vaccine dose.
Current Knowledge on Spinal Meningiomas Epidemiology, Tumor Characteristics and Non-Surgical Treatment Options: A Systematic Review and Pooled Analysis (Part 1)

Simple Summary Spinal meningiomas are the most common adult primary intradural spinal tumors and an up-to-date comprehensive summary of the current knowledge is greatly needed. An extensive review of the literature covering all aspects of spinal meningiomas was performed and a total of 104 studies were included. The pooled analysis revealed that most patients were female, in their seventh decade of life, with WHO grade 1 tumors. Moreover, interregional and age-related differences in epidemiology and/or histology were found. Sensory and motor dysfunction as well as pain were the most common presenting symptoms. Despite some promising results, the benefits of non-surgical treatments remain controversial. Abstract Background: Spinal meningiomas are the most common primary intradural spinal tumors. Although they are a separate entity, a large portion of the knowledge on spinal meningiomas is based on findings in intracranial meningiomas. Therefore, a comprehensive review of all the literature on spinal meningiomas was performed. Methods: Electronic databases were searched for all studies on spinal meningiomas dating from 2000 and onward. Findings of matching studies were pooled to strengthen the current body of evidence. Results: A total of 104 studies were included. The majority of patients were female (72.83%), elderly (peak decade: seventh), and had a world health organization (WHO) grade 1 tumor (95.7%). Interestingly, the minority of pediatric patients had a male overrepresentation (62.0% vs. 27.17%) and higher-grade tumors (33.3% vs. 4.3%). Sensory and motor dysfunction and pain were the most common presenting symptoms. Despite a handful of studies reporting promising findings associated with the use of non-surgical treatment options, the literature still suffers from contradictory results and limitations of study designs. Conclusions: Elderly females with WHO grade 1 tumors constituted the stereotypical type of patient. Compared to surgical alternatives, the evidence for the use of non-surgical treatments is still relatively weak.
Gaps in the continuum of care in HIV-positive adults and the need for caution in those returning to care after loss to follow-up

ABSTRACT Loss to follow-up (LTFU) and interruption of antiretroviral therapy (ART) are associated with worse outcomes in people with HIV (PWH). Little is known about gaps in the continuum of care. We conducted a retrospective cohort study including adult PWH with at least one clinical visit during 2000-2017. Three groups of care were defined: those constantly retained in care (constantly-RIC), definitively LTFU (dLTFU), and those who returned to care (RTC) after being LTFU for 1 year. We analyzed characteristics of individuals at enrollment. Among 2967 patients, 1565 (53%) were constantly-RIC, 826 (28%) dLTFU, and 576 (19%) RTC. CD4+ ≥350 cells/μL at enrollment was more frequent in RTC patients (43% vs 28% in both constantly-RIC and dLTFU groups, p < 0.01). Time since enrollment to ART initiation was longer in dLTFU (3.3 weeks) and RTC groups (6.0 weeks) in comparison with constantly-RIC patients (2.0 weeks, p < 0.01). Multivariate analysis showed significant differences between groups. Older and ART-naïve patients at enrollment were less likely to have gaps in the continuum of care. Those with non-MSM transmission were less likely to RTC. Patients with CD4+ ≥350 cells/μL at enrollment were more likely to reengage in care. Interventions should be tailored for those at risk of LTFU
Rhizobium pusense-Mediated Selenium Nanoparticles–Antibiotics Combinations against Acanthamoeba sp.

Severe ocular infections by Acanthamoeba sp. lead to keratitis, resulting in irreversible vision loss in immune-compromised individuals. When a protozoal infection spreads to neural tissues, it causes granulomatous encephalitis, which can be fatal. Treatment often takes longer due to the transition of amoeba from trophozoites to cyst stages, cyst being the dormant form of Acanthamoeba. A prolonged use of therapeutic agents, such as ciprofloxacin (Cipro), results in severe side effects; thus, it is critical to improve the therapeutic efficacy of these widely used antibiotics, possibly by limiting the drug-sensitive protozoal-phase transition to cyst formation. Owing to the biomedical potential of selenium nanoparticles (SeNPs), we evaluated the synergistic effects of ciprofloxacin and Rhizobium pusense–biogenic SeNPs combination. SeNPs synthesized using Rhizobium pusense isolated from root nodules were characterized using UV–Visible spectrophotometer, FT-IR, SEM with EDX, particle size analysis, and Zeta potential. The combination was observed to reduce the sub-lethal dose of Cipro, which may help reduce its side effects. The selenium and ciprofloxacin (SeNPs–Cipro) combination reduced the LC50 by 33.43%. The anti-protozoal efficacy of SeNPs–Cipro was found to transduce through decreased protozoal-cyst formations and the inhibition of the galactosidase and protease enzymes of trophozoites. Furthermore, high leakage of sugar, proteins, and amino acids during the SeNPs–Cipro treatment was one primary reason for killing the trophozoites. These experimental results may be helpful in the further pre-clinical evaluation of SeNPs–Cipro to combat protozoal infections. Future studies for combinations of SeNPs with other antibiotics need to be conducted to know the potential of SeNPs against antibiotic resistance in Acanthamoeba.
Response of Ecosystem Service Value to Landscape Pattern Changes under Low-Carbon Scenario: A Case Study of Fujian Coastal Areas

Assessing the influence of landscape pattern changes on ecosystem service value (ESV) is critical for developing land-use polies and increasing ecosystem services. The data sources include remote-sensing image data and statistical yearbooks from 2000, 2010, and 2020. This study employs the patch-generating land-use simulation model, landscape pattern index, and ecological service value estimation to analyse the changes in landscape patterns and ESV in Fujian coastal areas over the last 20 years. The landscape pattern and ESV in the future (2050) are then simulated under the low-carbon scenario (LCS), with the natural development scenario (NDS) serving as a comparison. The results show that: (1) the most noticeable changes from 2000 to 2020 are the reduced cultivated land area and the rapid expansion of construction land area. By 2050, construction land will account for 7.67% of the total land area under LCS, whereas NDS will account for 9.45%, and changes in the landscape pattern indices all indicate there will be greater variety and fragmentation of the landscape, with the NDS being more serious than the LCS; (2) From 2000–2020, the total ESV value showed a decreasing trend. In 2050, the ESV under the LCS will be 122.387 billion yuan, which is higher than the 121.434 billion yuan under the NDS. Regulating services contribute the most to the total ESV, followed by support services; and (3) In the past 20 years, except for a slight increase in water area, the ESV of other landscapes has decreased, with a net decrease of 3.134 billion yuan in total. The R2 fitting between the area change of cultivated and construction land and the total ESV reached 0.9898 and 0.9843, respectively. The correlations between ESV and landscape indices indicate that landscape pattern changes significantly impact ESV. Simulating ESV in LCS can provide guidance for optimising landscape patterns, promoting the benign operation of the regional ecosystem, and achieving sustainable ecological development.
Using Liu-Type Estimator to Combat Collinearity

Abstract Linear regression model and least squares method are widely used in many fields of natural and social sciences. In the presence of collinearity, the least squares estimator is unstable and often gives misleading information. Ridge regression is the most common method to overcome this problem. We find that when there exists severe collinearity, the shrinkage parameter selected by existing methods for ridge regression may not fully address the ill conditioning problem. To solve this problem, we propose a new two-parameter estimator. We show using both theoretic results and simulation that our new estimator has two advantages over ridge regression. First, our estimator has less mean squared error (MSE). Second, our estimator can fully address the ill conditioning problem. A numerical example from literature is used to illustrate the results.
Infective Endocarditis: Predictive Factors for Diagnosis and Mortality in Surgically Treated Patients

Background: Diagnosis of infective endocarditis (IE) often is challenging, and mortality is high in such patients. Our goal was to characterize common diagnostic tools to enable a rapid and accurate diagnosis and to correlate these tools with mortality outcomes. Methods: Because of the possibility of including perioperative diagnostics, only surgically treated patients with suspected left-sided IE were included in this retrospective, monocentric study. A clinical committee confirmed the diagnosis of IE. Results: 201 consecutive patients (age 64 ± 13 years, 74% male) were finally diagnosed with IE, and 14 patients turned out IE-negative. Preoperative tests with the highest sensitivity for IE were positive blood cultures (89.0%) and transesophageal echocardiography (87.5%). In receiver operating characteristics, vegetation size revealed high predictive power for IE (AUC 0.800, p < 0.001) with an optimal cut-off value of 11.5 mm. Systemic embolism was associated with mortality, and N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) had predictive power for mortality. Conclusion: If diagnostic standard tools remain inconclusive, we suggest employing novel cut-off values to increase diagnostic accuracy and accelerate diagnosis. Patients with embolism or elevated NT-proBNP deserve a closer follow-up.