Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of Southern Ocean in the global thermohaline circulation inferred from an OGCM

Nous presentons ici l'analyse dynamique quantitative de la circulation thermohaline de l'ocean meridional d’une simulation d’etat d’equilibre d’un modele couple glace de mer-ocean. L’etude vise a clarifier les roles des flux a la surface et du melange interne, avec une attention particuliere sur les mecanismes d’upwelling de l’eau profonde. Le premier resultat que nous nous presentons s’est une mise a niveau theorique du diagnostic des processus thermodynamiques des transformations des masses d’eau que represente une extension au domaine tridimensionnel (par exemple, aux sources internes telles que l’irradiance solaire) de l’approche classique. L’analyse montre que des flux de surface produisent presque 40 Sv d’eau modale Subantarctique. Le melange compense une bonne partie de ces transformations. La remontee de l’eau profonde d’Atlantique nord est du a des processus internes et principalement a la propagation verticale de l’exces d’eau douce de surface par l’intermediaire du melange vertical a la base de la couche melangee. Une analyse lagrangienne a permis d’identifier les parcours associees a la circulation thermohaline dans l’ocean Austral modele. Ce dernier presente une transformation des eaux de la thermohaline dans des eaux modales et une transformation profonde liee a la formation de l’eau antarctique de fond. En plus il est un puissant consommateur de l’eau profonde d’Atlantique Nord (80%). Enfin, en utilisant les donnees in situ NODC, nous avons reanalyse la formation et exportation de l'eau intermediaire antarctique de l'Ocean Austral vers le Pacifique Sud.
First record of Toxodontidae (Mammalia, Notoungulata) from the late Miocene—early Pliocene of the southern central Andes, NW Argentina

Abstract. A new species of toxodontid notoungulate, Xotodon maimarensis n. sp. , is described from the Maimará Formation (late Miocene—early Pliocene), Jujuy Province, northwestern Argentina. This is the first record of a toxodontid from the Eastern Cordillera. The specimen is housed at the Museo de Geología, Mineralogía y Paleontología, Instituto de Geología y Minería de la Universidad Nacional de Jujuy. It consists of an incomplete mandible preserving the right mandibular ramus with part of the dental series, partially preserved symphysis with all the incisors, and a small portion of the left ramus without teeth. The following characters distinguish it as a new taxon: symphysis long and narrow with slight divergence of its lateral borders; strong procumbence of lower incisors and deeply implanted i3; chin angle lower than in X. major and X. cristatus and bulging labial keel limiting strong lateral concavities. Comparative analysis in the context of the recently revised Neogene Toxodontidae indicates that the Maimará specimen shares mandibular features and dental characters with Xotodon and Mixotoxodon, differing from the latter by the more upraised symphysis. The phylogenetic position of Xotodon maimarensis n. sp. supports the taxonomic interpretation of the studied specimen as a new species of Xotodon. This new Toxodontidae increases the knowledge of the diversity and radiation of this group of notoungulates in northwest Argentina.
Development of MOKE spectrometer

The magneto-optical Kerr effect (MOKE) describes the change in polarization of light reflected from a magnetic surface. This change is proportional to the magnetization and depends on the wavelength of light. Because of these properties, MOKE has found use as a tool to probe magnetism in matter. The aim of the project is to develop an experimental setup to measure the wavelength dependence of MOKE. This is of interest as it can be used to determine the wavelength that gives the largest change in polarization to optimize measurements and provide information about the electronic structure of the sample. Initially, the experimental setup used a laser with tunable wavelength. However, it turned out to be pulsed, which made it incompatible with the rest of the setup. Therefore, three lasers with fixed wavelengths were instead used. The setup was evaluated by measuring the Kerr rotation and hysteresis curves for three Ni samples with varying thicknesses and a TbCo sample, at three different wavelengths. The primary finding was that the setup is not suitable for spectroscopic measurements due to the inability to compare values obtained at different wavelengths. To facilitate spectroscopic measurements, a new light source with tunable wavelength is required. The setup is capable of measuring hysteresis curves.
THE GENERAL DIVISOR PROBLEM OF CUSP FORM COEFFICIENTS OVER ARITHMETIC PROGRESSIONS

Let f be a normalized primitive holomorphic cusp form of even integral weight k for the full modular group Γ = SL (2 , Z ), and denote by λ f ( n ) the n th normalized Fourier coeﬃcient of f . Let λ f × f ( n ) be the n th normalized coeﬃcient of the Dirichlet expansion of the Rankin-Selberg L -function L ( f × f, s ) associated with f . In this paper, we investigate the asymptotic behavior of the sum
Association between Genetic Polymorphism of The lncRNA MIAT rs1894720 with Ischemic Stroke Risk and lncRNA MIAT Expression Levels in The Blood after An Ischemic Stroke: A Case-Control Study

Objective: Genetic aspects can play an essential role in the occurrence and development of ischemic stroke (IS). Rs1894720 polymorphism is one of the eight single nucleotide polymorphisms (SNPs) in the long non-coding RNA (lncRNA) myocardial infarction-associated transcript (MIAT) locus. The aim of study is the lncRNA MIAT rs1894720 polymorphism decreases IS risk by reducing lncRNA MIAT expression. Materials and Methods: In this case-control study, we studied 232 Iranian patients and 232 controls. The blood samples were collected from patients admitted at different times after stroke symptoms. We enrolled 80, 78, and 74 patients who arrived at the hospital between 0-24, 24-48, and 48-72 hours after the first appearance of symptoms, respectively. DNA genotyping was done by the tetra-primer ARMS-PCR method. Circulating MIAT levels were evaluated by real-time polymerase chain reaction (PCR). Results: The GT genotype of MIAT rs1894720 showed a significant association with the risk of IS (OR=3.53, 95% CI=2.13-5.84, P<0.001). MIAT expression was higher relative to the control within the first hours after IS. The MIAT levels in IS patients with rs1894720 (GT) were significantly lower relative to patients who had the GG and TT genotypes. Linear regression model indicated a significant correlation between MIAT expression with atherosclerotic risk factors and types of stroke in IS patients. Receiver operating characteristic (ROC) curve analysis showed that the level of lncRNA MIAT after IS could be diagnostic with an area under the curve (AUC) of 0.82. The sensitivity and specificity were 80.17 and 67.24%, respectively (P<0.001). Conclusion: Our study demonstrated that the MIAT rs1894720 polymorphism (GT) might increase the risk of IS in the Iranian population. MIAT expression was up-regulated in our IS patients. Hence, it could be a diagnostic biomarker for IS.
Journal of Immunology Research and Therapy

Upon antigen recognition, naïve T cells have the capacity to and memory functions. T cell receptor stimulation, costimulation, and cytokines induce transcriptional program changes that critically regulate T cell proliferation, differentiation and surv immune response to primary antigen encounter, long antigen counters. Both CD4 and CD8 T cells have the capacity to form memory mediators of sustained anti-tumor immunity. Memory CD8 T cells can be classified into several subtypes based on their tissue-homing capacity, self-renewal capability and effector recall responsiveness. Better under programs that regulate the generation and maintenance of T cell subsets, particularly T memory subsets, may have significant implications in the development of cellular therapies that achieve long
Trait Energy and Fatigue Modify Acute Ingestion of an Adaptogenic-Rich Beverage on Neurocognitive Performance

: Background: Psychological research considers traits as a long-standing pre-disposition to an individual’s mood, whereas short-term feelings are categorized as states. We previously reported similar overall acute mental performance beneﬁts between an adaptogen-rich, caffeine-containing energy shot (e+Energy Shot–e+Shot; Isagenix International, LLC) and a caffeine-matched placebo Since the publication of that study, multiple studies have reported that trait mental and physical energy (TME/TPE), and trait mental and physical fatigue (TMF/TPF) status modify the effect of various interventions on neurocognitive performance. Therefore, we reevaluated our previously published work and accounted for the four traits. Methods: Participants ( n = 30) completed a series of questionnaires to determine baseline trait energy and fatigue measures. Then, participants performed a 27 min battery of neurocognitive tasks before and three times after consuming the study beverages with 10 min breaks between each post-consumption battery of tests. Data from the previous study were re-analyzed using linear mixed-effects models. Results: We now report that the adaptogen product significantly improved mood and cognitive test responses in individuals stratified by initial TME, TPE, TMF, and TPF status. Moreover, this reevaluation also indicated that the caffeine placebo significantly increased heart rate and blood pressure in those subjects initially characterized by low physical and mental energy. Conclusions: In summary, a post-hoc re-analysis of our initial study suggests that consumption of the adaptogen-rich, caffeine-containing product preferentially benefited individuals with initial low TME/TPE and high TMF status when compared to caffeine alone. These findings also support our previous study suggesting that adaptogens may promote mental and physical performance benefits while modulating potentially negatively associated responses to caffeine.
istorica lovenica S tudia H istorica S lovenica

: The main purpose of our study was 1) to test for gender differences in subjective health and well-being, political and cultural participation; 2) to examine whether gender moderates the link between health and participation; and 3) to test for regional variation in this link. A representative survey sample of Slovenian Youth 2010 study was analysed. At the total sample levels, men reported better health, there were no gender differences in voter turnout, while cultural participation was higher among women. In addition, gender did not moderate cultural participation-health link (no significant link in either gender), but it did moderate voter turnout-health link, with turnout being significantly negatively related to health among men (but not among women). Regional variations were not detected, as associations within regions were largely insignificant.
Can Adults Revise Their Core Beliefs about Objects?

A set of fundamental principles governs our reasoning about objects since infancy. Studies have shown that adults are surprised when they observe apparent violations of these principles, which might prime them to learn from the violations and update their beliefs. However, little is known about whether these principles can be revised given counterevidence. In the present experiments, we demonstrate that although adults have strong prior beliefs about these principles, they can revise these beliefs in a specific, virtual world, when they observe multiple pieces of counterevidence.
The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia

Vanillin is the most important ﬂavor compound in the van-illa pod. Vanilla planifolia vanillin synthase ( Vp VAN) catalyzes the conversion of ferulic acid and ferulic acid glucoside into vanillin and vanillin glucoside, respectively. Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) of vanilla pod sections demonstrates that vanillin glu-coside is preferentially localized within the mesocarp and placental laminae whereas vanillin is preferentially localized within the mesocarp. Vp VAN is present as the mature form (25 kDa) but, depending on the tissue and isolation procedure, small amounts of the immature unprocessed form (40 kDa) and putative oligomers (50, 75 and 100 kDa) may be observed by immunoblotting using an antibody speciﬁc to the C-terminal sequence of Vp VAN. The Vp VAN protein is localized within chloroplasts and re-differentiated chloroplasts termed phenyloplasts, as monitored during the process of pod development. Isolated chloroplasts were shown to convert [ 14 C]phenylalanine and [ 14 C]cinnamic acid into [ 14 C]vanillin glucoside, indicating that the entire vanillin de novo biosynthetic machinery converting phenylalanine to vanillin glucoside is present in the chloroplast.
Herpes Zoster Vaccine Uptake and Active Campaign Impact, a Multicenter Retrospective Study in Italy

The Herpes Zoster (HZ) vaccination has proven both safe and effective in alleviating conditions related to HZ, leading to significant cost savings in national healthcare and social systems. In Italy, it is recommended and provided free of charge to individuals aged 65 and older. To achieve broad vaccination coverage, alongside ordinary immunization campaigns, active and catch-up campaigns were implemented. This retrospective observational study aimed to observe the vaccination coverage achieved in the Romagna Local Health Authority (LHA) during the 2023 active campaign, with a secondary goal of assessing the impact of the 2022 catch-up campaign and the 2023 active campaign compared to ordinary campaigns. As of 3 July 2023, an overall vaccine uptake of 13.5% was achieved among individuals born in 1958, with variations among the four LHA centers ranging from 10.2% to 17.7%. Catch-up and active campaigns together contributed to nearly half of the achieved coverage in Center No. 1 and a quarter in Center No. 2. Notably, individuals born in 1957, not included in the Center No. 2 catch-up campaign, reached significantly lower vaccination coverage compared to other cohorts and centers. Analyzing the use of text messages for active campaigns, it was observed that cohort groups did not show substantial differences in text-message utilization for warnings. However, having relatives who had experienced HZ-related symptoms significantly reduced the reliance on text messages as warnings. These results highlighted how catch-up and active campaigns effectively increased vaccine coverage. Nevertheless, differences in uptake among different centers within the same LHA and the limited contribution of other information sources compared to text messages suggest the necessity of designing campaigns involving all available channels and stakeholders to maximize vaccine uptake.
Temporal and Spatial Variations of Freshwater Reservoir Ages in the Loire River Watershed

Abstract In order to map the freshwater reservoir effect (FRE) variability of the Loire River and its tributaries, spatial and temporal carbon isotope (13C and 14C) analyses of the dissolved inorganic carbon (DIC) were conducted. Sites were selected to represent the diversity of geological settings, soil type, and land use. Results show a large spatial variability of 14C FRE ranging between 135 and 2251±30 yr, objectively correlated to DIC contents and alkalinity. Deeper investigations of the relationship between 14C activity of DIC and environmental variables show that the geological substrate is the dominant factor in the 14C reservoir effect, and far more influential than the river flow discharge.
A novel nomogram using PSA mass for predicting BPH

In 2019, there were 94 million cases of benign prostatic hyperplasia globally among men aged 40 years and older. Assessment of prostate volume (PV) is important in evaluating lower urinary tract symptoms and risks in asymptomatic individuals. Serum prostate-specific antigen (PSA) levels have been suggested as a convenient and useful biomarker for benign prostate hyperplasia (BPH). However, studies suggest that using PSA as a biomarker for BPH and prostate cancer can lead to underestimation of disease severity in patients with a high body mass index (BMI). PSA mass has been proposed as a potentially superior predictor compared to total PSA levels. This retrospective study recruited the male patients visiting Kuang Tien General Hospital who had serum PSA level test, underwent transrectal ultrasonography (TRUS) for evaluation of prostate volume between January 2009 and December 2019. PSA mass was obtained by calculating body surface area (BSA) and plasma volume. The data were proved to build a nomogram, to predict the volume of the prostate, and its accuracy was evaluated using internal validation techniques. Statistical analyses were performed using SAS and R. A total of 417 men were included in this study, with a mean age of 67.3 years, mean BMI of 24.9 kg/m 2 , mean prostate volume of 43.87 mL, mean PSA level of 2.94 ng/mL, and mean PSA mass of 8.68 ng/mL. The results showed that PSA mass had a higher accuracy than PSA in predicting prostate volume, as evidenced by a higher area under curve (AUC) value of 0.8271 for the PSA mass model compared to 0.8218 for the PSA model. Our nomogram showed a satisfying prediction accuracy. PSA mass may be a superior predictor of prostate volume compared to total PSA levels, although only slight improvement was shown.
Lysosomal storage disorders identified in adult population from India: Experience of a tertiary genetic centre and review of literature

Abstract Lysosomal storage disorders (LSDs) in adults have milder phenotype and variable age at presentation. Several studies have described the phenotype, genotype and treatment outcomes for adult‐onset LSDs like Gaucher, Fabry, Pompe disease and others. We describe the first systematic study on the occurrence of LSDs in an adult population from India. It describes, the key clinical signs seen in these patients and those from literature review that can aid in early detection. Of 2102 biochemically diagnosed LSDs cases, 32 adult patients were identified with LSDs. Based on the clinical suspicion, screening test and enzyme study was carried out. Twenty‐two patients were subjected to a genetic study to identify the causative variant in a respective gene. Of the 32 adult patients, we observed a maximum percentage of 37.5% (n = 12) cases with Gaucher disease, followed by 13% (n = 4) with Fabry disease. We found 10% of cases with MPS IVA and MPS I, and 9% cases with Pompe. Single case of adult mucolipidosis III and two cases each of Type 1 Sialidosis, Niemann‐Pick disease B and metachromatic leukodystrophy were identified. We observed two common variants p.Leu483Pro and p.Ala487Thr in the GBA1 gene in 23% of Indian patients with adult Gaucher disease. No common variants were observed in other aforementioned LSDs. Study identified 50% of Fabry patients and 4% of Gaucher patients diagnosed at our centre to be adults. The prevalence of adult Pompe patients was low (3.4%) as compared to 80% reported in the Caucasian population. Adult LSDs such as, MPS III, GM1/GM2 gangliosidosis and Krabbe disease were not identified in our cohort.
Management of Normogonadotropic males with idiopathic infertility with bilateral varicocelectomy with and without intramuscular recombinant FSH and HCG course(s): A twenty-year- experience in a prospective, controlled, and randomized clinical study

This study presents a clinical prospective double-blinded study that contains three groups of infertile males with normogonadotropic oligoasthenospermia. All groups A, B, and C were operated on for their bilateral varicoceles. The first included 152 patients who were only operated for bilateral varicocele (nominated group A). The second group of 237 patients constituted those who were operated on, with fertile female partners, and whose preoperative spermogram showed a count lower than 15 million/ml and a 3-hour-motility lower than 20%. This group constituted two categories based on their treatment. Therefore, groups B and C received postoperative courses of intramuscular injections of recombinant follicle-stimulating hormone (rFSH) and human chorionic gonadotropin (HCG), i.e., group B received one course (3 months), and group C received two courses (6 months). The main objective is to determine the improvement in the postoperative seminal parameters in the different groups. The sample constituted 391 infertile males who were recruited conveniently based on their willingness to share their progress information and were also informed that they could stop their participation freely with no questions asked. In our treated patients, in both groups B and C, who received 1 or 2 courses of rFSH and HCG, spontaneous pregnancy occurred in 69 patients and 52 patients, respectively. Likewise, assisted pregnancy occurred in 28 and 19 patients, respectively. So treated males of groups B and C resulted in 91/140 (65%) and 61/96 (63.54%) live offspring, respectively.
Mechanisms of coral resilience at the Houtman Abrolhos Islands: resistance, recovery, and adaptation

v Publications from thesis . ix List of Tables. xv List of Figures . xviii Chapter I: General Introduction . 1 Background . 1 Resilience . 3 Resistance . 4 Recovery . 5 Adaptation . 7 Chapter II: Exploring Symbiodinium diversity and host specificity from geographical extremes of Western Australia with amplicon pyrosequencing . 11 Abstract . 1
Analysis of Indonesian Domestic Tourist Quality

Domestic tourism is being the main focus of the government strategy to revitalize the tourism sector. It is then crucial to consider elements that can raise the quality of tourism, in terms of domestic tourists and increase the added value rather than merely number of trips. The analysis of quality is important in tourism to support the idea of sustainable tourism, which is promoted in the 8th agenda of Sustainable Development Goals (SDGs). Quality analysis must be done in micro modelling that takes into account tourist characteristics and particular travel-related features because this sector depends on tourism demand and tourist expenditure in tourist locations. Thus, the goal of this study is to give a general overview of the qualities and characteristics of domestic tourists and to examine how these attributes affect their quality. The results of descriptive analysis method indicate that Indonesian domestic visitors’ quality remains poor. Age, genders, education level, employment status, transportation mode, accommodation type and travel companion affect the quality of domestic tourists.
Interference Effects on Procedural Memory

Three experiments were conducted assessing interference effects acting on procedural task learning and performance using the Tower of Hanoi puzzle as the target procedural task. Experiment 1 found that participants in the no retroactive interference (RI) group completed the Tower of Hanoi task faster than the RI groups, with no differences between the type of the tactile interference. These results indicate that RI may hinder procedural task performance, but does not differentiate between consolidation and retrieval. Experiment 2 addressed RI placement by manipulating the delay prior to the interference task. Subsequent analyses suggested that interfering with only consolidation or recall does not produce interference effects, but qualitative feedback regarding emotion raised further questions about the effects of affect induction. Experiment 3 attempted to address the influence of a proactive and retroactive affect induction technique, but was unsuccessful in producing a dichotomous happy versus neutral effect. However, it was noted that alertness changed across the task acquisition stage, and the change in alertness may account for enhanced procedural memory acquisition. Overall, the series of experiments conducted provides conceptual replication of some previous research while contradicting other findings. This research not only extends our current understanding but also highlights the need to replicate research and continue to explore factors that may influence the practice or acquisition of novel procedural tasks.