Miracle-dz/UniFAR-FTUs huggingface dataset:
DDDT_A_252060 5143..5153

*These authors contributed equally to this work Introduction: Skin damage due to overexposure to ultraviolet B (UV-B) radiation can lead to the development of cancers and reduce the skin’s functionality as a vital protective barrier. Epidermal stem cells (ESCs) are pluripotent cells responsible for skin regeneration and healing. Upon exposure to UV-B radiation, ESCs produce excess amounts of reactive oxygen species (ROS) and inflammatory cytokines. However, the functional protection of ESCs is not fully explored. G-protein coupled G protein-coupled receptor 40 (Gpr40) is a free fatty acid receptor that is emerging as a potential treatment target for various diseases. Gpr40 has been found to be expressed in various cell types. Methods: ESCs were exposed to UV-B at the intensities of 25, 50, and 100 mJ/cm for 24 h using TL 20 W/12 RS UV lamps. ESCs were treated with UV-B at 50 mJ/cm in the presence or absence of 25 or 50 μM of the Gpr40 agonist GW9508 for 24 h. The gene expression of the Wnt1 pathway and proinflammatory cytokines were evaluated. To antagonize Gpr40 expression, ESCs were treated with 10 μM GW1100. Results: Our findings demonstrate that Gpr40 agonism can reduce the production of ROS as well as the expression of interleukins 1β and 8, two key proinflammatory cytokines. We demonstrate that agonism of Gpr40 can rescue the reduction in integrin β1 and Krt19 induced by UV-B exposure, thereby improving the capacities of ESCs to resist UV-B damage. Moreover, we show that the effects of Gpr40 agonism observed in our experiments are mediated through the Wnt/β-catenin canonical signaling pathway, as evidenced by the expression of Wnt1 and cyclin D1. Conclusion: Our findings present evidence of the role of Gpr40 agonism in mediating the protective capacities of ESCs against insult from UV-B radiation.
Kettleman hills landfill failure- investigation and lessons learned

SYNOPSIS The sliding stability failure of the Kettleman Hills waste landfill focused attention on several issues related to the safe design and filling of waste repositories, including low strengths between geosynthetic material interfaces in composite liner systems and low interface strength between compacted clay and smooth geomembranes. Waste placement plans must be carefully developed to insure an adequate factor of safety against sliding at all stages of filling. Because of assumptions and uncertainties that remained following the initial failure investigation, model tests, at a scale of 1:150, were done. These tests reproduced the field failure very well and provided insights into the failure mechanisms. A three-dimensional method for stability analysis gave results in close agreement with field observations and the results of a subsequent detailed failure investigation done by others (Byrne et al., 1992). Those special cases of landfill geometry and liner properties for which the 3D stability may be more critical than that computed using usual 2D methods of analysis could then be determined.
Proximate, Mineral and Phytochemical Analysis of Piliostigma Thonningii Stem Bark and Roots

Proximate, mineral and phytochemical composition of Piliostigma thonningii stem bark and roots was investigated to determine the level of bioactive chemicals in the plant. The result revealed that proximate composition of Piliostigma thonningii stem bark (PSSB) contained moisture 7.11 %, dry matter (DM) 92.89 %, crude protein (CP) 4.22 %, crude fibre (CF) 52.81 %, ether extract (EE) 0.08 %, ash 8.11 %, carbohydrate 20.12 %, Nitrogen free extract (NFE) 26.67 % and energy 488.7 KJ/100g while Piliostigma thonningii root (PSSR) contained 8.34 % moisture, 91.66 % (DM), 7.40 % (CP), 41.60 % (CF), 2.10 % (EE), 12.80 % ash, 42.30 % carbohydrates, 27.76 % (NFE) and energy 922.6 KJ/100g. Mineral analysis of PSSB revealed the presence of Ca (55.19 mg/100g), P (29.93 mg/100g), Mg (40.10 mg/100g), K (18.73 mg/100g), Zn (12.09 mg/100g), Mn (3.11 mg/100g), Na (20.40 mg/100g), Cu (8.01 mg/100g), Fe (48.12 mg/100g), Cr (0.010 mg/100g), livestock production.
The Open Psychology Journal Towards a Dynamic Assessment of Unilateral Spatial Neglect

: Background: The traditional paper and pencil tests are often inadequate to detect the mild forms of unilateral spatial neglect (USN). Objective: To verify the effectiveness of a touchscreen-based cancellation test in assessing individuals with USN. Methods: Seven individuals, six with right and one with left brain damage, who showed moderate to severe USN at admission, were involved in the study. Besides classic paper and pencil tests, participants were presented with a new, “user-friendly”, device consisting of an interactive “table” that integrates the principles of ecologic interaction and sophisticated technology. Such a touch screen table made possible to analyse the spatial and temporal evolution of the participants’ performance, providing a set of indices related to “how” the different tasks have been fulfilled, rather than simple raw scores. Results: This new technological approach turned out to be much more sensitive than the classic paper and pencil tests to detect the slightest forms of USN. In particular, while four out of the seven participants, performed flawless on the papery version of the Albert’s test, all of them made errors on the technological versions of the same Albert’s test. Finally, under all the different experimental conditions, participants achieved always a better performance when asked to erase rather than mark stimuli. Conclusion: Such a device has a potential in the ecological assessment of USN as well as in monitoring its evolution. Although in need of further substantiation, our findings further support the need to go beyond the traditional paper and pencil tests in the assessment of USN. The information provided by a more dynamic approach seems to be relevant for both clinical and research purposes.
Proposta di costruzione di un questionario sui sistemi motivazionali interpersonali (Q-SMI)

I sistemi motivazionali interpersonali sono «sistemi di regole innate», che orientano il comportamento sociale e l’esperienza emotiva di ogni individuo, rispetto al raggiungimento di scopi fondamentali per la sopravvivenza della nostra specie. Partendo dall’ipotesi che ogni individuo possa attivare alcuni sistemi motivazionali piu di altri, il presente lavoro propone un questionario self-report, per l’individuazione di profili motivazionali individuali. Una prima versione del questionario e stata somministrata a 600 soggetti che non hanno in corso alcuna diagnosi psicopatologica. Le analisi statistiche mostrano 6 dimensioni su 8 ben delineate - Rango-Sottomissione RAS, Affiliazione AF, Sessuale SEX, Rango-Dominanza RAD, Accudimento AC, e Gioco Sociale GIO. I risultati sembrano interessanti rispetto a differenze di genere ed eta del campione esaminato. Sembra dunque esserci la possibilita che un profilo motivazionale individuale sia realmente esistente e uno strumento come questo possa coglierlo. L’intento futuro degli autori del presente lavoro, sara quello di modificare gli item delle due dimensioni non ancora ben delineate - Attaccamento AT e Paritetico PA - al fine di mettere a punto una versione finale del questionario utilizzabile ai fini clinici e di ricerca.
Isoﬂurane Alters Angiotensin II–Induced Ca 2 (cid:1) Mobilization in Aortic Smooth Muscle Cells from Hypertensive Rats Implication of Cytoskeleton

Background: Angiotensin II (AngII) is a potent vasoconstrictor involved in the short-term control of arterial blood pressure. Isoﬂurane was reported to decrease vascular tone through an alteration of vascular smooth muscle cell vasomotor response to several agonists, but its effect on AngII signaling is not known. On the other hand, vascular response to AngII is altered in hypertension. In this study, the authors tested the hypothesis that (1) isoﬂurane alters AngII-induced intracellular Ca 2 (cid:1) mobilization in aortic vascular smooth muscle cell from Wistar Kyoto and spontaneously hypertensive rats, and (2) this effect could be associated with an alteration of the organization of microtubular network, reported to be involved in AngII signaling. Methods: The effect of 0.5–3% isoﬂurane was studied (1) on AngII (10 (cid:2) 6 M )-induced intracellular Ca 2 (cid:1) mobilization, intracellular Ca 2 (cid:1) release from internal stores, and Ca 2 (cid:1) inﬂux in Fura-2 loaded cultured aortic vascular smooth muscle cell iso- lated from 6-week-old Wistar Kyoto and spontaneously hypertensive rats, using ﬂuorescent imaging microscopy; and (2) on the organization of cytoskeletal elements, using immunoﬂuo- rescence labeling. Results: In both stains, isoﬂurane decreased in a concentra-tion-dependent manner AngII-induced intracellular Ca 2 (cid:1) mobilization, Ca 2 (cid:1) release from internal stores, and Ca 2 (cid:1) inﬂux through nifedipine-insensitive Ca 2 (cid:1) channels. This effect oc-curred at a lower concentrations of isoﬂurane in Wistar Kyoto rats than in spontaneously hypertensive rats. In both strains, the effect of isoﬂurane on AngII–Ca 2 (cid:1) mobilization was abolished by impairment with nocodazole, vinblastine, or paclitaxel of microtubules polymerization. Isoﬂurane directly altered tubular network organization in a concentration-dependent and reversible manner. Conclusions: Isoﬂurane decreased AngII-induced Ca 2 (cid:1) mobilization at clinically relevant concentrations, suggesting that vascular response to AngII could be altered during isoﬂurane anesthesia. The hypertensive strain was found less sensitive than the normotensive one. In both strains, the isoﬂurane effect was associated with a microtubular network interaction.
Development: A Case Study of Sunrise Boarding School, Nepal

The study aimed to investigate English pronunciation problems among Nepalese students and to develop the students’ pronunciation in Sunrise Boarding School, Nepal. Sixty Nepalese students were the participants of this study. Before treatment, a pretest was designed to evaluate the students’ mispronunciation. The pretest result showed 10 mispronounced English sounds. The dominant stage of this study was treatment in which posters and online lessons were used to support the students’ process of pronunciation learning. The lessons were designed based on Interaction Hypothesis (IH), the belief that learners will have development in L2 if they face difficulties and make an effort to interact with other speakers. The results reveal that the students can pronounce English sounds more accurately as problematic sounds were corrected during the treatment.
Using Process Theory for Accumulating Project Management Knowledge: A Seven-Category Model

Process theory has become an important mechanism for the accumulation of knowledge in a number of disciplines. Process theory focuses on sequences of activities, their durations, and the intervals between them, as they lead to specific outcomes. Thus, process theory is particularly relevant to project management knowledge representation and accumulation. We present a seven-category model that specifies different formulations of process theory, explaining how it can be applied and leveraged to accumulate knowledge, specifically within project management research. “… You simply don't go out and do a piece of work. No, the first thing you do is determine the lengthy sequence of activities necessary even to begin the job. Then you realize that the sequence of preparatory activities is so long you will never get to the intended task. So you go fishing instead. ” Patrick F. McManus (1989, p. 1) “Sequences” in The Night the Bear Ate Goombaw
egg extracts increase dynamics of histone H1 on sperm

Background: Linker histone H1 has been studied in vivo and using reconstituted chromatin, but there have been few systematic studies of the effects of the cellular environment on its function. Due to the presence of many other chromatin factors and specific chaperones such as RanBP7/importin beta that regulate histone H1, linker histones likely function differently in vivo than in purified systems. Methodology/PrincipalFindings: We have directly compared H1 binding to sperm nuclei in buffer versus Xenopus egg extract cytoplasm, and monitored the effects of adding nuclear import chaperones. In buffer, RanBP7 decondenses sperm nuclei, while H1 binds tightly to the chromatin and rescues RanBP7-mediated decondensation. H1 binding is reduced in cytoplasm, and H1 exhibits rapid FRAP dynamics in cytoplasm but not in buffer. RanBP7 decreases H1 binding to chromatin in both buffer and extract but does not significantly affect H1 dynamics in either condition. Importin beta has a lesser effect than RanBP7 on sperm chromatin decondensation and H1 binding, while a combination of RanBP7/importin beta is no more effective than RanBP7 alone. In extracts supplemented with RanBP7, H1 localizes to chromosomal foci, which increase after DNA damage. Unlike somatic H1, the embryonic linker histone H1M binds equally well to chromatin in cytoplasm compared to buffer. Amino-globular and carboxyl terminal domains of H1M bind chromatin comparably to the full-length protein in buffer, but are inhibited , 10-fold in cytoplasm. High levels of H1 or its truncations distort mitotic chromosomes and block their segregation during anaphase. Conclusion/Significance: RanBP7 can decondense sperm nuclei and decrease H1 binding, but the rapid dynamics of H1 on chromatin depend on other cytoplasmic factors. Cytoplasm greatly impairs the activity of individual H1 domains, and only the full-length protein can condense chromatin properly. Our findings begin to bridge the gap between purified and in vivo chromatin systems.
Rank-based estimation in the (cid:1)(cid:1)(cid:1) 1 -regularized partly linear model for censored outcomes with application to integrated analyses of clinical predictors and gene expression data

We consider estimation and variable selection in the partial linear model for censored data. The partial linear model for censored data is a direct extension of the accelerated failure time model, the latter of which is a very important alternative model to the proportional hazards model. We extend rank-based lasso-type estimators to a model that may contain nonlinear effects. Variable selection in such partial linear model has direct application to high-dimensional survival analyses that attempt to adjust for clinical predictors. In the microarray setting, previous methods can adjust for other clinical predictors by assuming that clinical and gene expression data enter the model linearly in the same fashion. Here, we select important variables after adjusting for prognostic clinical variables but the clinical effects are assumed nonlinear. Our estimator is based on stratiﬁcation and can be extended naturally to account for multiple nonlinear effects. We illustrate the utility of our method through simulation studies and application to the Wisconsin prognostic breast cancer data set.
INVITED REVIEW: PART OF AN INVITED ISSUE ON TREE NUTRITION Nutrition of mangroves

Summary Mangrove forests dominate the world's tropical and subtropical coastlines. Similar to other plant communities, nutrient availability is one of the major factors in ﬂ uencing mangrove forest structure and productivity. Many mangrove soils have extremely low nutrient availability, although nutrient availability can vary greatly among and within mangrove forests. Nutrient-conserving processes in mangroves are well developed and include evergreeness, resorption of nutrients prior to leaf fall, the immobilization of nutrients in leaf litter during decomposition, high root/ shoot ratios and the repeated use of old root channels. Both nitrogen-use e ﬃ ciency and nutrient resorption e ﬃ ciencies in mangroves are amongst the highest recorded for angiosperms. A complex range of interacting abiotic and biotic factors controls the availability of nutrients to mangrove trees, and mangroves are characteristically plastic in their ability to opportunistically utilize nutrients when these become available. Nitrogen and phosphorus have been implicated as the nutrients most likely to limit growth in mangroves. Ammonium is the primary form of nitrogen in mangrove soils, in part as a result of anoxic soil conditions, and tree growth is supported mainly by ammonium uptake. Nutrient enrichment is a major threat to marine ecosystems. Although mangroves have been proposed to protect the marine environ-ment from land-derived nutrient pollution, nutrient enrichment can have negative consequences for mangrove forests and their capacity for retention of nutrients may be limited.
Some interactions of a vortex with a seamount

The initial value problem for the motion of an equivalent-barotropic vortex which is initially circular and of uniform potential vorticity near a circular seamount of constant height is studied within a quasigeostrophic framework using the method of contour dynamics. Given that the radius of the vortex is equal to the deformation radius, the nature of the interaction depends on four parameters: i) the distance of the vortex from the seamount relative to the deformation radius, ii) the radius of the seamount relative to the deformation radius, iii) the ratio of the non-dimensional height of the seamount relative to the Rossby number of the vortex (or, equivalently, the vortex intensity) and iv) the sense of the vortex circulation. Contour surgery experiments are used to investigate qualitative changes in behaviour of the vortex-seamount system as these parameters are varied. Of particular note is the generation of additional vortex features by the original vortex as it sweeps fluid from the seamount. Moreover, when the original vortex is an anticyclone, dipoles are frequently formed over a wide range of parameter values, which subsequently propagate away from the seamount.
VIA E-EMAIL

Email services use spam filtering algorithms (SFAs) to filter emails that are unwanted by the user. However, at times, the emails perceived by an SFA as unwanted may be important to the user. Such incorrect decisions can have significant implications if SFAs treat emails of user interest as spam on a large scale. This is particularly important during national elections. To study whether the SFAs of popular email services have any biases in treating the cam-paign emails, we conducted a large-scale study of the campaign emails of the US elections 2020 by subscribing to a large number of Presidential, Senate, and House candidates using over a hundred email accounts on Gmail, Outlook, and Yahoo. We analyzed the biases in the SFAs towards the left and the right candidates and further studied the impact of the interactions (such as reading or marking emails as spam) of email recipients on these biases. We observed that the SFAs of different email services indeed exhibit biases towards different political affiliations.
DATA MANAGEMENT SYSTEM BASED VIEWPOINT

the architecture of data management system based on viewpoint is to capitalize on efforts made to design an existing and well-established DMS (a reference system). To extract amounts of data from the reference DMS a piece of schema relevant to the new application needs a module, possibly personalizing it with extra-constraints with respect to the application under construction, and then managing a dataset using the resulting schema. We carry out our investigations in the setting of description logics which underlie modern ontology languages, like RDFS, OWL, and OWL2 from W3C. Notably, we focus on the DL-liteA dialect of the DL-lite family, which encompasses the foundations of the QL profile of OWL2 (i.e., DL-liteR): the W3C recommendation for efficiently managing large datasets. In this paper, we extend the existing definitions of modules and we introduce novel properties of robustness that provide means for checking easily that a robust module-based DMS evolves safely with respect to both the schema and the data of the reference
Synchronization of Large Josephson-Junction Arrays by Traveling Electromagnetic Waves

Josephson junctions can be used to generate terahertz radiation, but achieving high emission power requires phase locking of many junctions in an array. The conventional cavity-resonance (standing-wave) mechanism of phase locking an array becomes ineffective when the extent of the array becomes larger than the wavelength. This study of coherent superradiant emission from such large arrays of Nb/NbSi/Nb Josephson junctions finds evidence for another, nonresonant mechanism of synchronization, via a traveling wave. That mechanism seems to offer the possibility of phase locking very large arrays of coupled oscillators, of any type.
Ef ﬁ cacy and safety of intrathecal morphine for analgesia after lower joint arthroplasty: a systematic review and meta-analysis with meta-regression and trial sequential analysis

Widespread adoption of intrathecal morphine into clinical practice is hampered by concerns about its potential side-effects. We undertook a systematic review, meta-analysis and trial sequential analysis with the primary objective of determining the ef ﬁ cacy and safety of intrathecal morphine. Our secondary objective was to determine the dose associated with greatest ef ﬁ cacy and safety. We also assessed the impact of intrathecal morphine on respiratory depression. We systematically searched the literature for trials comparing intrathecal morphine with a control group in patients undergoing hip or knee arthroplasty under spinal anaesthesia. Our primary ef ﬁ cacy outcome was rest pain score (0 – 10) at 8 – 12 hours; our primary safety outcome was the rate of postoperative nausea and vomiting within 24 hours. Twenty-nine trials including 1814 patients were identi ﬁ ed. Rest pain score at 8 – 12 hours was signi ﬁ cantly reduced in the intrathecal morphine group, with a mean difference (95%CI) of (cid:1) 1.7 ( (cid:1) 2.0 to (cid:1) 1.3), p < 0.0001 (19 trials; 1420 patients; high-quality evidence), without sub-group differences between doses (p = 0.35). Intrathecal morphine increased postoperative nausea and vomiting, with a risk ratio (95%CI) of 1.4 (1.3 – 1.6), p < 0.0001 (24 trials; 1603 patients; high-quality evidence). However, a sub-group analysis by dose revealed that rates of postoperative nausea and vomiting within 24 hours were similar between groups at a dose of 100 µ g, while the risk signi ﬁ cantly increased with larger doses (p value for sub-group difference = 0.02). Patients receiving intrathecal morphine were no more likely to have respiratory depression, the risk ratio (95%CI) being 0.9 (0.5 – 1.7), p = 0.78 (16 trials; 1173 patients; high-quality evidence). In conclusion, there is good evidence that intrathecal morphine provides effective analgesia after lower limb arthroplasty, without an increased risk of respiratory depression, but at the expense of an increased rate of postoperative nausea and vomiting. A dose of 100 µ g is a ‘ ceiling ’ dose for analgesia and a threshold dose for increased rate of postoperative nausea and vomiting.