Miracle-dz/UniFAR-FTUs huggingface dataset:
Skills program for awareness, connectedness, and empowerment: A conceptual framework of a skills group for individuals with a psychosis-risk syndrome

Intervention strategies for those diagnosed with psychotic disorders such as schizophrenia can be effective in reducing symptoms and improving quality of life. While strides have been made in developing prevention and intervention strategies earlier on in the disease progression, among those at clinical high-risk (CHR) for psychosis, challenges with heterogeneity can limit symptom and diagnosis specific treatment. Here, we discuss a newly developed therapy skills group called the Skills Program for Awareness, Connectedness, and Empowerment (SPACE) that integrates different types of behavioral skills – standard and radically open dialectical behavioral therapy as well as cognitive behavioral therapy – for CHR youth between the ages of 13–18 years. With the diathesis-stress framework serving as a foundation, the intervention is divided into three stages. These stages target specific signs and symptoms contributing to the progression of CHR symptoms. Stage 1 targets stress (with the goal of developing awareness and reducing distress), stage 2 targets self-disturbances (with a goal of increasing self-connectedness), and stage 3 targets social connectedness (with a goal of improving social domains of functioning). The focus of this article is to introduce the theoretical framework underlying the pilot skills group and discuss ongoing progress. Clinical Trial Registration NCT05398120; https://clinicaltrials.gov/ct2/show/NCT05398120.
Large-scale vortex structures in turbulent wakes behind bluff bodies. Part 1. Vortex formation processes

An investigation of turbulent wakes was conducted and phase-averaged velocity vector fields are presented, as well as phase-averaged and global Reynolds normal and shear stresses. The topology of the phase-averaged velocity fields is discussed in terms of critical point theory. Here in Part 1, the vortex formation process in the cavity region of several nominally two-dimensional bluff bodies is investigated and described using phase-averaged streamlines where the measurements were made in a nominal plane of symmetry. It was found that the flows encountered were always three-dimensional and that the mean-flow patterns in the cavity region were quite different from those expected using classical two-dimensional assumptions.
Relationships between Obesity, Exercise Preferences, and Related Social Cognitive Theory Variables among Breast Cancer Survivors

Breast cancer survivors with obesity have an increased risk of cancer recurrence, second malignancy, and comorbidities. Though physical activity (PA) interventions are needed, investigation of the relationships between obesity and factors influencing PA program aspects among cancer survivors remain understudied. Thus, we conducted a cross-sectional study examining associations amongst baseline body mass index (BMI), PA program preferences, PA, cardiorespiratory fitness, and related social cognitive theory variables (self-efficacy, exercise barriers interference, social support, positive and negative outcome expectations) from a randomized controlled PA trial with 320 post-treatment breast cancer survivors. BMI was significantly correlated with exercise barriers interference (r = 0.131, p = 0.019). Higher BMI was significantly associated with preference to exercise at a facility (p = 0.038), lower cardiorespiratory fitness (p < 0.001), lower walking self-efficacy (p < 0.001), and higher negative outcome expectations (p = 0.024), independent of covariates (comorbidity score, Western Ontario and McMaster Universities osteoarthritis index score, income, race, education). Those with class I/II obesity reported a higher negative outcome expectations score compared with class III. Location, walking self-efficacy, barriers, negative outcome expectations, and fitness should be considered when designing future PA programs among breast cancer survivors with obesity.
Feasibility and scalability of a fitness tracker study: Results from a longitudinal analysis of persons with multiple sclerosis

Background Consumer-grade fitness trackers offer exciting opportunities to study persons with chronic diseases in greater detail and in their daily-life environment. However, attempts to bring fitness tracker measurement campaigns from tightly controlled clinical environments to home settings are often challenged by deteriorating study compliance or by organizational and resource limitations. Objectives By revisiting the study design and patient-reported experiences of a partly remote study with fitness trackers (BarKA-MS study), we aimed to qualitatively explore the relationship between overall study compliance and scalability. On that account, we aimed to derive lessons learned on strengths, weaknesses, and technical challenges for the conduct of future studies. Methods The two-phased BarKA-MS study employed Fitbit Inspire HR and electronic surveys to monitor physical activity in 45 people with multiple sclerosis in a rehabilitation setting and in their natural surroundings at home for up to 8 weeks. We examined and quantified the recruitment and compliance in terms of questionnaire completion and device wear time. Furthermore, we qualitatively evaluated experiences with devices according to participants' survey-collected reports. Finally, we reviewed the BarKA-MS study conduct characteristics for its scalability according to the Intervention Scalability Assessment Tool checklist. Results Weekly electronic surveys completion reached 96%. On average, the Fitbit data revealed 99% and 97% valid wear days at the rehabilitation clinic and in the home setting, respectively. Positive experiences with the device were predominant: only 17% of the feedbacks had a negative connotation, mostly pertaining to perceived measurement inaccuracies. Twenty-five major topics and study characteristics relating to compliance were identified. They broadly fell into the three categories: “effectiveness of support measures”, “recruitment and compliance barriers”, and “technical challenges”. The scalability assessment revealed that the highly individualized support measures, which contributed greatly to the high study compliance, may face substantial scalability challenges due to the strong human involvement and limited potential for standardization. Conclusion The personal interactions and highly individualized participant support positively influenced study compliance and retention. But the major human involvement in these support actions will pose scalability challenges due to resource limitations. Study conductors should anticipate this potential compliance-scalability trade-off already in the design phase.
Social mobility through higher education: exploratory analysis of ethno-racial, gender and class intersection in professional undergraduate programmes

ABSTRACT Higher education and elite professional occupations are considered to be key sources of social mobility. In this paper, we suggest that examining patterns of admission into professional undergraduate programmes, a key route for entry into elite professional occupations, may provide important insights into social mobility through higher education. We analyse university admission offer data and assess the impact of ethno-racial, gender and class intersection on relative likelihood of student admission to six elite professional programmes (medicine, law, accounting, architecture, engineering and business management), in comparison to non-professional programmes. Our exploratory analysis provides several interesting results; though they present a generally pessimistic picture of potential social mobility through higher education. We find that higher class background is a key factor in admissions to elite professional programmes, especially evident in the exemplar traditional professions of medicine and law; presumed gender effects on entry into technical math-based professional programmes, such as engineering and accounting, are substantially moderated by class background; and ethno-racial background may mitigate some of the class penalties for women, but leads to double penalty for black men. Our findings contribute directly to the current research on impact of class origin on social mobility, especially that on class ceiling. Further, we respond to recent calls for fuller inclusion of class in intersectionality-based research by showing how class may work both through and against other social factors, such as race and gender.
The Influence of a Chromospheric Magnetic Field on the Solar p- and f-Modes. II. Uniform Chromospheric Field

L'influence d'un champ magnetique chromospherique sur les oscillations solaires est analysee avec un modele d'atmosphere dont la zone convective du Soleil est representee par un fluide stratifie gravitationnellement, avec un profil de temperature lineaire, et est surmontee d'une chromosphere isotherme traversee par un champ magnetique horizontal uniforme. Une relation de dispersion pour les modes p et f est determinee.
Niclosamide does not modulate airway epithelial function through blocking of the calcium activated chloride channel, TMEM16A

Niclosamide and benzbromarone have been described as inhibitors of the calcium activated chloride channel, TMEM16A, and on this basis have been considered and tested as clinical candidates for the treatment of airway diseases. However, both compounds have previously demonstrated activity on a range of additional biological targets and it is unclear from the literature to what extent any activity on TMEM16A may contribute to efficacy in these models of airway disease. The aim of the present study was therefore to examine the pharmacology and selectivity of these clinical candidates together with a structurally unrelated TMEM16A blocker, Ani9, in a range of functional assays to better appreciate the putative role of TMEM16A in the regulation of both epithelial ion transport and the development of an airway epithelial mucus secretory phenoptype. Benzbromarone and Ani9 both attenuated recombinant TMEM16A activity in patch clamp studies, whereas in contrast, niclosamide induced a paradoxical potentiation of the TMEM16A-mediated current. Niclosamide and benzbromarone were also demonstrated to attenuate receptor-dependent increases in intracellular Ca2+ levels ([Ca2+]i) which likely contributed to their concomitant attenuation of the Ca2+-stimulated short-circuit current responses of FRT-TMEM16A and primary human bronchial epithelial (HBE) cells. In contrast, Ani9 attenuated the Ca2+-stimulated short-circuit current responses of both cell systems without influencing [Ca2+]i which supports a true channel blocking mechanism for this compound. Additional studies using HBE cells revealed effects of both niclosamide and benzbromarone on global ion transport processes (absorptive and secretory) as well as signs of toxicity (elevated LDH levels, loss of transepithelial resistance) that were not shared by Ani9. Ani9 also failed to influence the IL-13 induced differentiation of HBE towards a goblet cell rich, mucus hypersecreting epithelium, whereas niclosamide and benzbromarone attenuated numbers of both goblet and multiciliated cells, that would be consistent with cellular toxicity. Together these data challenge the description of niclosamide as a TMEM16A blocker and illustrate a range of off-target effects of both niclosamide and benzbromarone which may contribute to the reported activity in models of airway function.
Real value of the oocytes with smooth endoplasmic reticulum aggregates in in vitro fertilization/intracytoplasmic sperm injection cycle: a retrospective cohort study

Objective: The management of oocytes affected by smooth endoplasmic reticulum aggregates (SERa) remains debatable. To understand how to manage SERa+ oocytes and cycles, we performed a retrospective cohort study and analyzed the impact of SERa+ cycles and oocytes on clinical and neonatal outcomes. Methods: We included 4856 cycles (149 SERa+ and 4707 SERa−) from 4201 women (age: 21–42 years) who received in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatments at the Center of Reproductive Medicine, First Affiliated Hospital of Army Military University, from 2016 to 2019. SERa+ cycles had at least one SERa oocyte in the oocyte cohort. All 1722 oocytes in the SERa+ cycle were divided into SERa+ (405) and SERa− (1317) oocytes. Results: The rates of two pronuclei (2PN) and high-quality embryos were lower in SERa+ cycles than in SERa− cycles, regardless of IVF or ICSI (P <0.05). As the proportion of SERa+ oocytes increased in the SERa+ cycles, the rate of high-quality embryos declined gradually (P <0.05). Furthermore, the rate of 2PN in SERa+ oocytes was significantly lower than that in SERa− oocytes (P <0.05). Regardless of whether IVF or ICSI insemination was performed, no significant differences in terms of clinical pregnancy rate and spontaneous abortion rate were observed between SERa+ and SERa− cycles or between SERa+ and SERa− oocytes (P >0.05). Conclusion: Normal fertilization with SERa+ cycles and oocytes was substantially reduced, regardless of the insemination method. Embryos originating from SERa+ oocytes can be transferred when there are no other options, but fully informed consent and strict follow-up of fetal development are mandatory.
Synchrotron self-Compton flaring of TeV blazars I. Linear electron cooling

The vast improvement of the sensitivity of modern ground-based air Cherenkov telescopes, together with the sensitive flux measurements at lower frequencies, requires accurate elaborations of the theoretical radiation models for flaring blazars. Here the flaring of TeV blazars due to the synchrotron-self Compton (SSC) process is considered. We assume that, at the moment t = t0, a flare in the emission knot occurs due to the instantaneous injection of monoenergetic (E0) ultrarelativistic electrons. The ultrarelativistic electrons are injected uniformly over the knot volume and at later times are subject to linear synchrotron radiation cooling in a magnetic field whose strength remains constant during the time evolution of the relativistic electrons.The generated synchrotron photons are subject to multiple Thomson-scattering off the cold electrons in the source giving rise to spatial photon diffusion. Optically thick and thin synchrotron radiation intensities and photon density distributions in the emission knot as functions of frequency and time are analytically determined. The synchrotron photons serve as target photons for the SSC process, which is calculated in the optically thin frequency range using the Thomson approximation of the inverse Compton cross section. It is shown that the optically thick part of the synchrotron radiation process provides a negligible contribution to the resulting SSC intensity at all frequencies and times.Because the high-energy TeV photons undergo no elastic multiple Compton scatterings, we neglect the influence of photon diffusion in the calculation of the SSC intensity and fluence distribution with energy. The SSC fluence exhibits a break at Ef = 15.8b −1/3 GeV from a ∝E −1/4 s -power law spectrum at lower photon energies Et ≤ Es ≤ Ef to a ∝E −2 s [1 − (Es/E0)
Micromagnetic Study of the Dependence of Output Voltages and Magnetization Behaviors on Damping Constant, Frequency, and Wire Length for a Gigahertz Spin Rotation Sensor

In this report, we studied the dependence of output voltage on the damping constant, the frequency of the pulse current, and the wire length of zero-magnetostriction CoFeBSi wires using multiphysics simulation considering eddy currents in micromagnetic simulations. The magnetization reversal mechanism in the wires was also investigated. As a result, we found that a high output voltage can be achieved with a damping constant of ≥0.03. We also found that the output voltage increases up to a pulse current of 3 GHz. The longer the wire length, the lower the external magnetic field at which the output voltage peaks. This is because the demagnetization field from the axial ends of the wire is weaker as the wire length is longer.
Thermal Design of Uniformly Heated Inclined Channels in Natural Convection with and without Radiative Effects

Dimensional charts for the design of inclined single channels in air natural convection with symmetrical and asymmetrical uniform wall heat flux are proposed on the basis of correlations between the significant dimensionless process parameters derived from previous articles. The radiative contribution to heat transfer is taken into account. The design charts are obtained for two values of surface emissivity, 0.05 and 0.8, and the thermophysical properties are evaluated at the reference temperature equal to 40 ° C. The optimal spacing value for inclined single channels, in terms of thermal performance, is obtained from composite correlations between average Nusselt and Rayleigh numbers as functions of the angle. The estimated values of optimal spacing for vertical single channels correspond well with the results obtained by Bar-Cohen and Rohsenow [14]. A simple estimation procedure is proposed to evaluate the error in the relevant geometric and thermal parameters due to a different value of the reference temperature. The estimated error, however, is less than the uncertainty of the experimental data employed. Worked examples are carried out in order to show how simple and quick it is to use the proposed graphical procedure.
Demagnetizing factors of rectangular prisms and ellipsoids

We evaluate, using exact general formulas, the flux-metric and magnetometric demagnetizing factors, N/sub f,m/, of a rectangular prism of dimensions 2a/spl times/2b/spl times/2c with susceptibility /spl chi/=0 and the demagnetizing factor, N, of an ellipsoid of semiaxes a, b. and c along the c axis. The results as functions of longitudinal and transverse dimension ratios are listed in tables and plotted in figures. The three special cases of b/spl Gt/(ca)/sup 1/2/, b/spl Lt/(ca)/sup 1/2/, and a=b are analyzed together with the general case, to quantitatively show the validity of approximate formulas for special cases. N/sub f,m/ of prisms with any given values of /spl chi/ may be estimated to an accuracy about 10%, since 1) N/sub f,m/ of prisms with a=b are very near those of cylinders, for which the /spl chi/ dependence has been calculated quite completely; 2) the /spl chi/ dependence of the transverse N/sub f,m/ of prisms with b=/spl infin/ (rectangular bars) have recently been calculated completely; and 3) N/sub f,m/(X=/spl infin/) for prisms of great longitudinal dimension ratios are close to N of the corresponding ellipsoids. Thus, the existing very incomplete results can be used in some cases satisfactorily, although much work has to be done before the actual /spl chi/ dependence of N/sub f,m/ is available as it is for cylinders.
Fall Risk Prediction Using Wireless Sensor Insoles With Machine Learning

Accidental fall is a significant health risk among the elderly. However, most of the fall detection systems give notification only after a fall occurs. Therefore, medical attention has shifted to fall preventive measures to reduce risks of fall and prevent any damage entirely. As most fall prediction data in previous literature are obtained from inertial sensors or static pressure sensors, in this study, wireless pressure sensors embedded insoles are used to train machine learning (ML) models to predict the risk of fall of an individual. The novelty of this paper is that dynamic walking data is obtained by wearing smart pressure insoles from 1101 subjects. We applied six different ML models, i.e., support vector machine (SVM), random forest (RF), logistic regression (LR), naive bayes (NB), decision tree (DT), and k-nearest neighbor (kNN). Results show that LR model with oversampling techniques achieved the highest area under curve (AUC) of 0.82, whereas the RF model with oversampling achieved the highest accuracy of 0.81 and specificity of 0.88. The results show that such models combined with pressure embedded wireless sensor insoles are capable for fall risk prediction.
ES Aquilae Is an R Coronae Borealis Star

ES Aql, initially classified as a semiregular variable, is now believed to be a member of the R Coronae Borealis (RCB) class of stars, a small group of carbon‐rich supergiants that undergo dramatic declines in brightness at irregular intervals. We present photometry of ES Aql going back as far as 1893 using plates from the Harvard College Observatory as well as more recent photoelectric and visual observations. ES Aql displays the typical behavior of an RCB star, consisting of sharp declines at irregular intervals. The spectrum of ES Aql is also typical of a cool (Teff ∼ 5000 K) RCB star, showing strong absorption bands of C2 and CN, along with weak hydrogen and no detectable 13C. ES Aql is also an IRAS source indicating the presence of dust. Based on these data, we conclude that ES Aql is indeed an RCB star.
Next Generation BTK Inhibitors in CLL: Evolving Challenges and New Opportunities

Simple Summary Chronic lymphocytic leukemia (CLL) treatment scenario is rapidly evolving. As a consequence of longer observation, despite remarkable clinical results, treatment with ibrutinib is associated with long-term toxicities and resistance. New strategies based on BTK inhibition are under development, offering effective salvage treatment both to intolerant and refractory patients. This review is aimed at summarizing and discussing the role of next-generation BTK inhibitors in CLL. Abstract Ibrutinib revolutionized the CLL treatment approach and prognosis demonstrating its efficacy and safety even at extended follow-up. During the last few years, several next-generation inhibitors have been developed to overcome the occurrence of toxicity or resistance in patients on continuous treatment. In a head-to-head comparison of two phase III trials, both acalabrutinib and zanubrutinib demonstrated a lower incidence of adverse events in respect to ibrutinib. Nevertheless, resistance mutations remain a concern with continuous therapy and were demonstrated with both first- and next-generation covalent inhibitors. Reversible inhibitors showed efficacy independently of previous treatment and the presence of BTK mutations. Other strategies are currently under development in CLL, especially for high-risk patients, and include BTK inhibitor combinations with BCl2 inhibitors with or without anti-CD20 monoclonal antibodies. Finally, new mechanisms for BTK inhibition are under investigations in patients progressing with both covalent and non-covalent BTK and BCl2 inhibitors. Here we summarize and discuss results from main experiences on irreversible and reversable BTK inhibitors in CLL.