Miracle-dz/UniFAR-FTUs huggingface dataset:
Passivity-Based Control of Water Pumping System Using BLDC Motor Drive Fed by Solar PV Array with Battery Storage System

In remote locations, it is advisable to combine solar water pumping with electric energy storage and power supply for other forms of consumption. In such complex systems, individual subsystems feature their own local control, and the general automatic control of the system in different modes of its operation is carried out in accordance with an energy management strategy (EMS). In this paper, the functions of local and general control of the solar water pumping system with battery storage and external power supply are combined in the system of passivity-based control (PBC). The EMS is constructed in such a way that for all modes, only two PBC systems are developed, which are switched depending on the battery’s state of charge and the current levels of the two main disturbances—solar irradiation and electrical consumption. For each system, two control influence former (CIF) structures were synthesized and their operation was investigated by computer simulation. Despite the simplicity of CIFs’ implementation, due to the introduced interconnection and damping coefficients, such control allows the provision of the required voltage regulation with a static error up to 1%, sufficient quality of transients during disturbances and switching of the system structure, as well as system asymptotic stability.
Roles of the Na+/H+ Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion

Prostate cancer is a leading cause of cancer-associated deaths in men over 60 years of age. Most patients are killed by tumor metastasis. Recent evidence has implicated a role of the tumor microenvironment and urokinase plasminogen activator (uPA) in cancer cell migration, invasion, and metastasis. Here, we examine the role of the Na+/H+ exchanger isoform 1 (NHE1) and uPA in DU 145 prostate cancer cell migration and colony formation. Knockout of NHE1 reduced cell migration. The effects of a series of novel NHE1/uPA hexamethylene-amiloride-based inhibitors with varying efficacy towards NHE1 and uPA were examined on prostate cancer cells. Inhibition of NHE1—alone, or with inhibitors combining NHE1 or uPA inhibition—generally did not prevent prostate cancer cell migration. However, uPA inhibition—but not NHE1 inhibition—prevented anchorage-dependent colony formation. Application of inhibitors at concentrations that only saturate uPA inhibition decreased tumor invasion in vivo. The results suggest that while knockout of NHE1 affects cell migration, these effects are not due to NHE1-dependent proton translocation. Additionally, while neither NHE1 nor uPA activity was critical in cell migration, only uPA activity appeared to be critical in anchorage-dependent colony formation of DU 145 prostate cancer cells and invasion in vivo.
Perception of Students and Examiners about Objective Structured Clinical Examination in a Teaching Hospital in Ethiopia

Introduction The objective structured clinical examination (OSCE) has become a standard assessment tool in undergraduate medical school training. It is considered an objective assessment of practical skill of students. OSCE is a resource demanding assessment method that can have numerous challenges. Comprehensive assessment of perception regarding OSCE can help identify areas that need improvement. The aim of this study was to assess the perception of students and examiners towards OSCE. Methods A cross-sectional study was conducted on students and examiners undertaking OSCE from May 1 to July 30, 2021, using a structured questionnaire. Comparison of variables was done using Mann–Whitney U-Test and Chi-square test. P-value <0.05 was considered statistically significant. Results A total of 141 students and 39 examiners participated in the study. The majority of the students and examiners had a positive response regarding the attributes, structure, organization and validity of OSCE. It was recommended to be used in future exams compared to other assessments by 38.3% of students and 51.3% of examiners. There were certain challenges reported by students and included stressfulness of the exam (51.1%), inadequate time (27.6%), and unsatisfactory orientation (30.5%). One-third of examiners considered it stressful, while 20.5% considered the time provided to be inadequate. Equipment to conduct the exam was considered inadequate by 39.1% and 56.4% of students and examiners, respectively. Around 80.1% of students recommended mock sessions and 23.1% of examiners did not have any prior training on OSCE. Conclusion An overall positive perception of OSCE by students and examiners was seen. Certain challenges that need improvements were identified. Continuing evaluation and refinement of OSCE by departments is needed. We recommend further wide-scale national evaluation of the OSCE examination system of medical students.
Bazedoxifene activates the angiotensin II-induced HUVEC hypertension model by targeting SIRT1

The shift in vascular function to vasoconstriction, pro-inflammatory state, oxidative stress and carbon monoxide deficiency may to endothelial dysfunction and injury, which is the key event in hypertension. Estrogen receptor modulators play a protective role in blood vessels. The present study aimed to investigate the effect of bazedoxifene, a selective estrogen receptor modulator, on human umbilical vein endothelial cells (HUVECs) and its potential underlying mechanism of action. The present study treated endothelial cells with different concentrations of bazedoxifene and determined cell viability using Cell Counting Kit-8 to screen for the optimal working concentration of bazedoxifene. Subsequently, an angiotensin II (AngII)-induced vascular endothelial cell model was established to observe the effect of bazedoxifene on AngII-induced endothelial cells. The concentrations of nitric oxide (NO) and reactive oxygen species (ROS) were detected using NO and ROS kits, respectively. The protein expression of sirtuin 1 (SIRT1), oxidative stress-related proteins and apoptosis-related proteins was detected using western blotting, and apoptosis was detected using a TUNEL assay. The results demonstrated that bazedoxifene promoted AngII-induced HUVEC viability, reduced the expression of stress-related proteins and inhibited apoptosis. Furthermore, bazedoxifene activated SIRT1 to promote the proliferation and inhibit the oxidative stress and apoptosis of AngII-induced HUVECs. These findings suggested that bazedoxifene could effectively promote AngII-induced HUVEC proliferation and inhibit cell apoptosis and oxidative stress. In addition, bazedoxifene protected HUVEC dysfunction induced by AngII by targeting the activation of SIRT1. In summary, bazedoxifene could improve the protective role against hypertension induced by AngII.
A Quasi‐experimental study on prevention and reduction of involuntary treatment at home (PRITAH) in people with dementia

Abstract Aim and objectives To examine the implementation (reach, dose, fidelity, adaptations, satisfaction), mechanisms of impact (attitude, subjective norm, perceived behavioural control and intention) and context of the PRITAH intervention. Background Involuntary treatment, defined as care provided against one's will, is highly prevalent in home care. The PRITAH intervention comprises policy, workshops, coaching and alternative measures for professional caregivers to prevent and reduce involuntary treatment in home care. Design Quasi‐experimental study. Methods Eight home care teams from two care organisations participated in this study. Guided by the Theory of Planned Behavior, the mechanisms of impact were evaluated with questionnaires. Implementation and context were assessed using attendance lists, evaluation questionnaires, focus groups and logbooks. The study adhered to the TREND checklist. Results 124 of 133 eligible professional caregivers participated (93%). All four components were delivered with minor deviations from protocol. Participants' subjective norms and perceived behavioural control changed over time in favour of the intervention group. No effects were seen for attitude and intention. Barriers included an unclear policy and lack of communication between stakeholders. The multidisciplinary approach and possibility to discuss involuntary treatment with the specialised nurse were described as facilitators. Conclusions Prevention and reduction of involuntary treatment at home is feasible in home care practice and contributes to changing professional caregivers' subjective norms and perceived behavioural control, prerequisites for behavioural change in order to prevent and reduce involuntary treatment. A follow‐up study on the effectiveness of PRITAH on actual use, prevention and reduction of involuntary treatment in home care is needed. Future studies should emphasise the role of family caregivers and GPs and actively involve them in the prevention and reduction of involuntary treatment. Relevance to clinical practice Involuntary treatment is commonly used in dementia home care and professional and family caregivers need to be supported in prevention and reduction of involuntary treatment in people with dementia.
Supervisory control of hybrid powertrains: An experimental benchmark of offline optimization and online energy management

Abstract The paper describes a chain of tools aimed at the development and validation of energy management strategies (EMS) for hybrid powertrains. These tools comprise an offline optimizer based on Pontryagin minimum principle (PMP) and the online equivalent consumption minimization strategy (ECMS), both implemented in a dynamic simulation platform and as a real-time controller in a semi-physical testing equipment. The results presented are aimed at illustrating the continuity of the various approaches by comparing the offline-generated energy management laws with their online counterparts, both in terms of trajectories over time and in terms of global results (fuel consumption, state-of-charge deviations).
Divalent Metal Ions Boost Effect of Nucleic Acids Delivered by Cell-Penetrating Peptides

Cell-penetrating peptides (CPPs) are promising tools for transfection of various substances, including nucleic acids, into cells. The aim of current work was to search for novel safe and effective approaches for enhancing transfection efficiency of nanoparticles formed of CPP and splice-correcting oligonucleotide (SCO) without increasing the concentration of peptide. We analyzed an effect of inclusion of calcium and magnesium ions into nanoparticles on CPP-mediated transfection in cell culture. We also studied the mechanism of such transfection as well as its efficiency, applicability in case of different cell lines, nucleic acid types and peptides, and possible limitations. We discovered a strong positive effect of these ions on transfection efficiency of SCO, that translated to enhanced synthesis of functional reporter protein. We observed significant changes in intracellular distribution and trafficking of nanoparticles formed with addition of the ions, without increasing cytotoxicity. We propose a novel strategy of preparing CPP-oligonucleotide nanoparticles with enhanced efficiency and, thus, higher therapeutic potential. Our discovery may be translated to primary cell cultures and, possibly, in vivo studies, in the aim to increase CPP-mediated transfection efficiency and likelihood of using CPPs in clinics.
Low-cost electronic weighing lysimeters

ABSTRACT Evapotranspiration research lysimeters with 1 nfi area and 1.2 m depth were designed and constructed using commercially available cantilever load cells. These lysimeters were operated continuously for a three-year period at the Drainage Research Farm of Utah State University. Resolution of daily measurements of evapotranspiration (Et) from the fescue/forage grass mix was generally better than 0.05 mm or 1%. Accuracy of hourly measurements of E^ was influenced by numerical resolution of the data logger and slight thermal instabilities within the load cells. Lysimeter measurements agreed well with Et estimated with the Penman-Monteith method. The total cost for a two-lysimeter installation including labor was $11,000. Maintenance and operation requirements were low.
The Beta-Cell Function and Glucose Profile of Newly Diagnosed Acromegalic Patients with Normal Glucose Tolerance

Objectives Untreated acromegaly is a nature model for unveiling the diabetogenic effects of GH. CGMS can uncover more glucose profile of acromegaly. This study aimed to evaluate the insulin resistance (IR), β-cell function, and glycemic spectrum of patients with newly diagnosed acromegaly with normal glucose tolerance (NGT). Methods This study was conducted in Huashan Hospital from January 2015 to February 2019. Eight newly diagnosed acromegalic patients without history of diabetes and eight age- and gender-matched healthy subjects were enrolled. All participants underwent oral glucose tolerance test (OGTT) and 72 h continuous glucose monitoring (CGM). Parameters on β-cell function and IR were calculated. Mean blood glucose (MBG) in 24 hours was adopted for the evaluation of the glycemic level, and standard deviation of blood glucose (SDBG) and mean amplitude of glycemic excursion (MAGE) were used for glucose fluctuation. Results HbA1c in the acromegaly group was significantly higher than in the control. During OGTT, glucose peaked at 60 min in acromegaly and at 30 min in controls. After glucose load, the acromegaly group had significantly higher insulin levels than controls, especially in 120 min and 180 min. Both insulin sensitivity index and disposal index after glucose load of acromegaly were significantly lower than those of controls. Moreover, acromegalic subjects had significantly higher MBG than controls. Conclusions The newly diagnosed acromegalic patients with NGT were characterized by IR and impaired β-cell function after glucose load. CGM showed that MBG of NGT acromegaly patients was higher than that of normal people.
Palaeohistological inferences of resting metabolic rates in Concornis and Iberomesornis (Enantiornithes, Ornithothoraces) from the Lower Cretaceous of Las Hoyas (Spain)

The bone histology of non‐avian theropods such as Troodon, early pygostylians such as Confuciusornis, and neornithines, is characterized by the post‐hatching formation of fibrolamellar complex. In contrast, the cortex of enantiornithine birds, like Concornis and Iberomesornis, is made of poorly vascularized parallel‐fibred tissue. The cortex of metatarsals of Concornis lacustris MCCM‐LH21006 is composed of a thin layer of lamellar endosteal bone and a thick layer of almost avascular parallel‐fibred periosteal bone organized into an inner part containing large spherical osteocyte lacunae and a few secondary osteons, and an outer part containing flattened osteocyte lacunae and lines of arrested growth. The cortex of metatarsals of Iberomesornis sp. MCCM‐LH09681 is similar to the inner layer described in Concornis. Endosteal bone, and the outer layer of periosteal bone containing flattened osteocytes and lines of arrested growth, are missing in Iberomesornis, suggesting that this specimen is a sub‐adult. Here we test statistically a hypothesis suggesting that the absence of post‐hatching formation of fibrolamellar bone in Enantiornithes may be a side effect of their low resting metabolic rates (RMR). For this, we construct a palaeobiological inference model including osteocyte lacunar density (explaining a significant fraction of variation in RMR) and phylogenetic eigenvectors as predictor variables. RMR inferred for Concornis and Iberomesornis are significantly higher than those measured in extant ectotherms, but they are not significantly different from the RMR measured in a sample of extant arboreal perching Neornithes of similar body size. We conclude that the ‘intermediate physiological condition’ hypothesis is rejected.
UK Trainee Cardiothoracic Surgeons’ Perceptions of Public Outcome Reporting in Surgery: A Mixed-Methods Study

Background Since 2004, the Society for Cardiothoracic Surgery in Great Britain and Ireland has reported outcomes of named surgeons. In 2013, the National Health Service England published outcome data for 10 specialties, including cardiothoracic surgery. Before this, no consistent and major stakeholder feedback had occurred. This is the first study to assess UK trainee cardiothoracic surgeons’ perceptions of public outcome reporting (POR) in surgery. Methodology In this study, first, an online survey was sent to all trainee cardiothoracic surgeons (n = 257) in the UK. The survey had a response rate of 17%. Second, 10 semi-structured, one-to-one interviews were conducted with trainee cardiothoracic surgeons who had completed the survey. Results The majority of respondents opposed the public release of surgeon-specific mortality data in adult cardiac surgery. It is believed to be associated with several consequences, including risk aversion, ‘gaming’, and detriments to the training and development of surgeons. Despite this, the majority of respondents favoured the POR of alternative outcome measures, including unit mortality, which provides a better indicator for the overall quality of care provided to patients. Conclusions Trainee cardiothoracic surgeons accept and approve of POR. However, policymakers should refine the current strategy if they are to receive full support from the future of the specialty.
Systematic Review: A Comparison between Vancomycin and Daptomycin for Sepsis Infection Antibiotic Therapy

BACKGROUND: Sepsis is a dangerous condition that threatens life because of immune system dysregulation caused by an infection resulting in organ failure. One of the most common resistant strain bacteria that can cause sepsis is Methicillin-resistant Staphylococcus aureus (MRSA). Vancomycin is the first-line therapy for treating sepsis infection caused by MRSA, but recently there have been some MRSA strains that are resistant to vancomycin therapy. AIM: This study aimed to review comparison between vancomycin and daptomycin for sepsis infection antibiotics therapy. MATERIALS AND METHODS: This research was a systematic review using three databases such as PubMed, ProQuest, and ScienceDirect. The journal articles included in this study were about randomized controlled trial (RCT) studies published from 2011 to 2020. RESULTS: This research included seven RCT studies, but none of them discuss the usage of daptomycin for sepsis treatment caused by MRSA. They discuss more the effect of dose, method of administration, and side effects of vancomycin therapy in relation to the outcome of the patient. CONCLUSIONS: Because of the lack of RCT articles that conducted experiments of daptomycin usage for sepsis treatment caused by MRSA infection, this research could not compare the effectiveness between vancomycin and daptomycin. However, from some case reports included in this research, there was evidence that the usage of daptomycin base after vancomycin treatment failure will cause another treatment failure.
Electron Transport in Double-Barrier Semiconductor Heterostructures for Thermionic Cooling

We investigate electron transport in asymmetric double-barrier (Al, Ga ) As / GaAs thermionic cooling heterostructures. Measurements of temperature-dependent current-voltage characteristics conﬁrm that the dominant electron transport is a sequential process of resonant tunneling injection into and thermionic emission from the quantum-well (QW) cooling layer. The thermal activation energy of the current is found to be strongly dependent on the bias voltage. Furthermore, instead of showing a simple thermal activation behavior, the current exhibits rather complicated temperature and voltage dependence, particularly when the thermionic emission barrier is low. To establish a quantitative understanding, we develop an intuitive analytical model for sequential electron transport that explicitly takes into account scattering eﬀects in the thermionic emission process from the two-dimensional QW states to the three-dimensional above-barrier states. The observed temperature-dependent sequential current is well explained by the present theory. DOI: 10.1103/PhysRevApplied.16. 064017
Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination

During meiotic prophase, cohesin-dependent axial structures are formed in the synaptonemal complex (SC). However, the functional correlation between these structures and cohesion remains elusive. Here, we examined the formation of cohesin-dependent axial structures in the fission yeast Schizosaccharomyces pombe. This organism forms atypical SCs composed of linear elements (LinEs) resembling the lateral elements of SC but lacking the transverse filaments. Hi-C analysis using a highly synchronous population of meiotic S. pombe cells revealed that the axis-loop chromatin structure formed in meiotic prophase was dependent on the Rec8 cohesin complex. In contrast, the Rec8-mediated formation of the axis-loop structure occurred in cells lacking components of LinEs. To dissect the functions of Rec8, we identified a rec8-F204S mutant that lost the ability to assemble the axis-loop structure without losing cohesion of sister chromatids. This mutant showed defects in the formation of the axis-loop structure and LinE assembly and thus exhibited reduced meiotic recombination. Collectively, our results demonstrate that the Rec8-dependent axis-loop structure provides a structural platform essential for LinE assembly, facilitating meiotic recombination of homologous chromosomes, independently of its role in sister chromatid cohesion.
Advanced thin-film silicon-on-sapphire technology: microwave circuit applications

This paper reviews the prospects of thin-film silicon-on-sapphire (TFSOS) CMOS technology in microwave applications in the 1-5 GHz regime and beyond and presents the first demonstration of microwave integrated circuits based on this technology, MOSFET's optimized for microwave use, with 0.5-/spl mu/m optically defined gate lengths and a T-gate structure, have f/sub t/ values of 25 GHz (14 GHz) and f/sub max/ values of 66 GHz (41 GHz) for n-channel (p-channel) devices and have noise figure values below 1 db at 2 GHz, some of the best reported performance characteristics of any silicon-based MOSFET's to date. On-chip spiral inductors exhibit quality factors above ten. Circuit performance compares favorably with that of other CMOS-based technologies and approach performance levels similar to those obtained by silicon bipolar technologies. The results demonstrate the significant potential of this technology for microwave applications.
Safety of shallow foundations – Limit State Design according to Eurocode 7 vs. alternative design concepts

The main objective of Eurocode 7 was to harmonise geotechnical design in Europe by consistently implementing limit state design. However, Eurocode 7 only provides a framework in which each member state defines the design approach as well as the partial factors according to national design and safety requirements. The design approaches differ in the way partial factors are applied and lead to remarkably different designs especially in the case of shallow foundations under complex loading. Hence, the actual safety of the foundation cannot be reliably determined. In the present paper the correlations between loads and resistances of shallow foundations within Eurocode 7 design are analysed by use of interaction diagrams. The effects of the design approaches on the overall safety are discussed. An alternative design method based on an unique failure criterion for the ultimate limit state is introduced, the implementation of the partial factor concept is discussed.