Miracle-dz/UniFAR-FTUs huggingface dataset:
in the Contrasting Regional Zeitgeists

Since the Industrial Revolution, the world economy has enjoyed ongoing productivity increases that have steadily raised global living standards in the context of a growing world population. This represents a change from the reality prior to roughly 1820, which was marked by long-term stagnation in both living standards and population levels, a condition referred to as the Malthusian Trap (Maddison, 1982). The vast historical literature on the Industrial Revolution, complemented by recent advances in growth theory, demonstrates that capitalism has been able to break this historical trap for more than two centuries through a powerful systemic capacity to generate productivity-increasing innovations. Within this two-century period, however, innovation has not occurred evenly over time nor over geographical territory. The time dynamic is that major innovations occur in waves, and are centered on sets of technologies and their principal industries, such as the textile technology revolution of the late eighteenth and early nineteenth centuries, with its harnessing of water power sources and its mechanical innovations for weaving. In the nineteenth century, technologies around steel, coal, and railroads generated another major wave of productivity increases. In the very late nineteenth century and early twentieth century, the internal combustion engine, electricity, and more mechanical engineering technologies generated another astonishing wave of productivity gains (Gordon, 2016).
Modelling the effects of petroleum product contaminated sand on the compressive strength of concretes using fuzzy logic and artificial neural networks: A case study of diesel

In this study an artificial neural network (ANN) and fuzzy logic (FL) were used to predict the compressive strength of concrete produced with diesel contaminated sand. Concrete was produced using sand contaminated with diesel at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5 and 10 percent, and each batch cured for 7, 14, 28, 58, 90 and 118 days. The compressive strength of the concretes was measured for each percentage contamination and curing time. Subsequently, an ANN and FL models were developed used to predict the compressive strength of the concrete. The ANN model predictions with a correlation coefficient (R) of 0.99316 predicted better than two FL models which predicted with correlation coefficient (R) values of 0.9086 and 0.8038 respectively. The results show that ANN and FL models could be used to predict the compressive strength of concretes produced with diesel contaminated sand.
Effects of 7-Interferon on the Endocrine System: Results from a Phase I Study1

Interferon causes profound biological changes when given to patients with cancer and many of these could not be predicted from in vitro or animal model systems. We documented significant changes in hormonal levels for a group of 18 patients who were participants in a Phase I 7interferon trial. Adrenocorticotropic hormone, cortisol, and growth hor mone were all significantly elevated 2 h after treatment with 7-intcrfcron, with cortisol and adrenocorticotropic hormone returning to base line by 24 h. A placebo group failed to show this change, suggesting a specific interferon effect. Possible mechanisms for these findings and implications for the use of interferons are discussed.
Asian Transport Studies, Volume 5, Issue 2 (2018), 243-255

This paper proposes an approach to estimate the value of motorcycle equivalent units (MEU), which are very important for studies of motorcycle-dominated traffic flows. With some minor adjustments, the proposed approach can also be applied to car-dominated traffic flows. A model for MEU estimation was developed using real-world traffic data collected in Vietnam. The proposed model describes the relationship between MEU values and significant parameters such as trajectory, velocity, and safety distance. The MEU values estimated using the proposed model were compared with values estimated using previously proposed models. The results show that the MEU values estimated using the proposed model are quite stable and can be applied to many types of roadway geometries in developing countries.
Factors Contributing to Increased Blast Overpressure

This study demonstrates the orientation and the ‘shape factor’ have pronounced effects 17 on the development of the localized pressure fields inside of the helmet. We used anatomically 18 accurate headform to evaluate four modern combat helmets under blast loading conditions in the 19 shock tube. The Advanced Combat Helmet (ACH) is used to capture the effect of the orientation on 20 pressure under the helmet. The three modern combat helmets: ECH, Ops-Core, and Airframe, were 21 tested in frontal orientation to determine the effect of helmet geometry. Using the unhelmeted 22 headform data as a reference, we characterized pressure distribution inside each helmet and 23 identified pressure focal points. The nature of these localized “hot spots” is different than the 24 elevated pressure in the parietal region of the headform under the helmet widely recognized as the 25 under-wash effect also observed in our tests. It is the first experimental study which indicates that 26 the helmet presence increased the pressure experienced by the eyes (as evidenced by the pressure 27 sensors in the H8 and H9 locations), and the forehead (denoted as H1 location). Pressure 28 fingerprinting using an array of sensors combined with the application of principle component 29 analysis (PCA) helped elucidate the subtle differences between helmets. 30
SCHOOL INCLUSION AND AUTISM: TEACHERS’ FEELINGS AND PRACTICES

The school is characterized as an important space for the development of social and cognitive competences of children, including those with Autism Spectrum Disorder (ASD). Given this context, this study investigated the teachers ‘experience regarding the inclusion of students with ASD, contemplating teachers’ feelings and practices. It is a qualitative research, exploratory and transverse in nature. Four teachers from early years of elementary school who had a student with ASD enrolled in the class participated. A semi-structured interview was used and the analysis was qualitative, through thematic analysis. It was shown that the first feelings that emerged in teachers were fear and insecurity. After the period of adaptation, these feelings changed, becoming safety in their work. Regarding the pedagogical practice, it was verified that the teachers made pedagogical adjustments according to the characteristics of each student. el grupo. Se utilizó de una entrevista semiestructurada y el análisis fue cualitativo, por intermedio del análisis temático. Se evidenció que los primeros sentimientos que emergieron en los profesores fueron el miedo y la inseguridad. Tras el período de adaptación, esos sentimientos se modificaron, transformándose en seguranza en su labor. Con relación a la práctica pedagógica, se verificó que los docentes realizaron adecuaciones pedagógicas de acuerdo con las características de cada alumno.
Cone A b-metric space and some coupled fixed point theorems

In this paper, we extend the definition of coupled fixed point to mappings on cone Ab-metric space and prove some coupled fixed point theorems. Our results extend the coupled fixed point results of Singh and Singh [K. A. Singh, M. R. Singh, J. Math. Comput. Sci., 10 (2020), 891–905] to cone Ab-metric space. An example is also given to illustrate the validity of our result.
Risk profile analysis of uncomplicated type B aortic dissection patients undergoing thoracic endovascular aortic repair: Laboratory and radiographic predictors

There is emerging evidence to support pre‐emptive thoracic endovascular aortic repair (TEVAR) intervention for uncomplicated type B aortic dissection (unTBAD). Pre‐emptive intervention would be particularly beneficial in patients that have a higher baseline risk of progressing to complicated TBAD (coTBAD). There remain debate on the optimal clinical, laboratory, morphological, and radiological parameters, which would identify the highest‐risk patients that would benefit most from pre‐emptive TEVAR.
Risk of out-of-hospital cardiac arrest in patients with rheumatoid arthritis: a nationwide study

Aim Inflammatory cytokines in patients with rheumatoid arthritis (RA) directly affect cardiac electrophysiology by inhibiting cardiac potassium currents, leading to delay of cardiac repolarisation and QT-prolongation. This may result in lethal arrhythmias. We studied whether RA increases the rate of out-of-hospital cardiac arrest (OHCA) in the general population. Methods We conducted a nested case–control in a cohort of individuals between 1 June 2001 and 31 December 2015. Cases were OHCA patients from presumed cardiac causes, and were matched with non-OHCA-controls based on age, sex and OHCA date. Cox-regression with time-dependent covariates was conducted to assess the association between RA and OHCA by calculating the HR and 95% CI. Stratified analyses were performed according to sex and presence of cardiovascular diseases. Also, the association between OHCA and use of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with RA was studied. Results We included 35 195 OHCA cases of whom 512 (1.45%) had RA, and 351 950 non-OHCA controls of whom 3867 (1.10%) had RA. We found that RA was associated with increased rate of OHCA after adjustment for cardiovascular comorbidities and use of QT-prolonging drugs (HR: 1.22, 95% CI: 1.11 to 1.34). Stratification by sex revealed that increased OHCA rate occurred in women (HR: 1.32, 95% CI: 1.16 to 1.50) but not in men (HR: 1.12, 95% CI: 0.97 to 1.28; P value interaction=0.046). OHCA rate of RA was not further increased in patients with cardiovascular disease. Finally, in patients with RA, use of NSAIDs was not associated with OHCA. Conclusion In the general population, RA is associated with increased rate of OHCA in women but not in men.
Syringenes M – Q, Eremophilane Sesquiterpenoid Dimers from the Peeled Stems of Syringa pinnatifolia

As a part of systematic studies on Syringa pinnatifolia, a continued phytochemical investigation guided by 1H‐NMR and LC/MS data on the ethanol extract afforded five new dimeric eremophilane sesquiterpenoids, namely syringenes M−Q (1–5). These structures were elucidated by extensive analysis of spectroscopic data, including infrared (IR), high‐resolution electrospray ionization mass spectrometry (HR‐ESI‐MS), nuclear magnetic resonance (NMR), quantum‐mechanics‐based computational analysis of NMR chemical shifts, and single‐crystal X‐ray diffraction. Compounds 4 and 5 showed inhibitory activities against NO production induced by lipopolysaccharide in RAW264.7 macrophage cells, with IC50 values of 5.1 and 9.3 μM, compared to positive control indomethacin (IC50 33.6 μM). These dimeric eremophilane sesquiterpenoids may be potential markers for discriminating this species from the genus Syringa and the Oleaceae family.
The utility of erythrocyte sedimentation rate, C-reactive protein, and procalcitonin in detecting infections in patients with systemic lupus erythematosus: A systematic review

Objectives We conducted a systematic review with metanalysis to investigate the utility of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and procalcitonin (PCT) in diagnosing infections in hospitalized patients with SLE. Methods We searched Medline, Embase, Web of Science, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials (CENTRAL) with a search strategy developed by a medical librarian. We included retrospective, cross-sectional, case-control, and prospective studies in our analysis. We used the Quality Assessment of Diagnostic Studies (QUADAS-2) to assess for bias and applicability. We obtained mean differences, sensitivities, and specificities in our analysis. Results We included 26 studies in our analysis. Most studies had an unclear or high risk of bias and our results were widely heterogenous. For the diagnosis of infections, the CRP had a pooled sensitivity of 0.75 (95%CI 0.57-0.94) and specificity of 0.72 (0.59-0.85), PCT had a pooled sensitivity of 0.68 (95% CI 0.0.59–0.77) and specificity of 0.75 (0.59–0.90), and for ESR pooled estimates were not calculated but sensitivity ranged from 50 to 69.8 and specificity from 38.5 to 55.6. Modifying cut-offs improved sensitivities and specificities. The ESR, CRP, and PCT mean differences were all greater in infection groups versus non-infection (10.1, 95% CI 3.2–17.0; 46.8, 95% CI 36.5–57.0; 0.53, 95% CI 0.26–0.80; respectively). Discussion Poor sensitivities and specificities were observed for the evaluated biomarkers with substantial heterogeneity in the cut-offs used to determine infection. Although mean biomarker values were increased in the infection group compared with the non-infection, our findings do not support the widespread use of ESR, CRP, or PCT in diagnosing infection in hospitalized patients with SLE due to increased heterogeneity and risk of bias. Further investigation is needed.
Estimation of familial recurrence risk of malignancy: Application of liability threshold model in genetic counseling

Apart from some Mendelian‐inherited tumors, malignancies are multifactorial diseases, and reported data are often the only sources to estimate familial recurrence risk. Edwards' approximation formula has provided one way forward, but it uses estimates only from incidence in the general population, and is thus too simple to be widely utilized for complex individual instances. On the other hand, the heritability of malignancies has been estimated from twin studies, and it has been found that different tumors have rather different heritability. In the present study, I report a method to estimate the familial recurrence risk from the population incidence and the heritability of each malignancy, applying Falconer's liability threshold model. Trial calculations with this method using literature data support its potential use. For example, the calculation indicated that the relative risk of developing stomach cancer is 2.1 times in the first‐degree relatives than in the general population whereas for leukemia the risks were estimated to be 7.4 times and 2.9 times for the first‐ and the second‐degree relatives, respectively. Thus, the proposed method could be a useful tool in genetic counseling for risk of malignancies.
The nonclassical MHC class I Qa-1 expressed in layer 6 neurons regulates activity-dependent plasticity via microglial CD94/NKG2 in the cortex

Significance Molecules regulated by neuronal activity are necessary for circuits to adapt to changing inputs. Specific classical major histocompatibility class I (MHCI) molecules play roles in circuit and synaptic plasticity, but the function of most members of this family remains unexplored in brain. Here, we show that a nonclassical MHCI molecule, Qa-1 (H2-T23), is expressed in a subset of excitatory neurons and regulated by visually driven activity in the cerebral cortex. Moreover, CD94/NKG2 heterodimers, cognate receptors for Qa-1, are expressed in microglia. A functional interaction between Qa-1 and CD94/NKG2 is necessary for regulating the magnitude of ocular dominance plasticity during the critical period in the visual cortex, implying an interaction in which activity-dependent changes in neurons may be monitored by microglia.
Examining grieving problem correlates of anticipation of the death vs. shock among overdose death and suicide bereaved adults

Abstract We conducted an online survey with individuals bereaved by drug deaths (n = 115), suicide (n = 185) and sudden natural deaths (n = 103), including questions about anticipating the death vs. shock, other behaviors, established measures of mental health and grieving difficulties. Results showed more drug death bereaved anticipating their loved one’s death while suicide bereaved were more shocked. Death shocked respondents showed greater PTSD, other mental health, and grieving problems; those anticipating the death had less PTSD, grieving problems, and engaged in more meaning-making. These contrasting patterns should call for diverging clinical strategies in offering aid to these traumatically bereaved mourners.
A Survey of Helicobacter pylori Antibiotic-Resistant Genotypes and Strain Lineages by Whole-Genome Sequencing in China

Antibiotic resistance is the most important factor leading to failed Helicobacter pylori eradication therapy, and personalized treatment based on antibiotic susceptibility is becoming increasingly important. To strengthen the understanding of antibiotic genotypic resistance of H. pylori and identify new antibiotic resistance loci, in this study, we identified phenotypic resistance information for 60 clinical isolates and compared the concordance of phenotypic and genotypic resistance using whole-genome sequencing (WGS). ABSTRACT Antibiotic resistance is the most important factor leading to failed Helicobacter pylori eradication therapy, and personalized treatment based on antibiotic susceptibility is becoming increasingly important. To strengthen the understanding of antibiotic genotypic resistance of H. pylori and identify new antibiotic resistance loci, in this study, we identified phenotypic resistance information for 60 clinical isolates and compared the concordance of phenotypic and genotypic resistance using whole-genome sequencing (WGS). Clarithromycin and levofloxacin genotypic resistance was in almost perfect concordance with phenotypic resistance, with kappa coefficients of 0.867 and 0.833, respectively. All strains with the R16H/C mutation and truncation in rdxA were metronidazole resistant, with 100% specificity. For other genes of concern, at least one phenotypically sensitive strain had a previous mutation related to antibiotic resistance. Moreover, we found that the A1378G mutation of HP0399 and the A149G mutation of FabH might contribute to tetracycline resistance and multidrug resistance, respectively. Overall, the inference of resistance to clarithromycin and levofloxacin from genotypic resistance is reliable, and WGS has been very helpful in discovering novel H. pylori resistance loci. In addition, WGS has also enhanced our study of strain lineages, providing new ways to understand resistance information and mechanisms.
Management of Magnet Ingestions at a Large Tertiary Care Children’s Hospital

Objectives: To review the clinical management and outcomes of magnet ingestions at a large tertiary children’s hospital. To determine the association of frequency of high-powered magnet ingestion with the regulation of these magnets. Methods: Children <18 years who presented to the emergency room and were admitted to the Children’s Hospital of Philadelphia for ingestion of single or multiple magnets from January 2008 to December 2020 were included. Demographics, symptoms, management, and outcomes were analyzed. The frequency of magnet ingestion was compared over 3 eras: (1) pre-ban (2008–2012), (2) intra-ban (2013–2016), and (3) post-ban (2017–2020). Results: There were 167 magnet ingestions, including 99 with multiple magnets. Most patients (59%) were male and median age was 6 (interquartile range, 3–9) years. Most single magnet ingestions (86%) were discharged with outpatient monitoring, and none experienced severe outcomes. Multiple magnet ingestions led to significant morbidity including hospitalizations (68%), endoscopic procedures (48%), surgical procedures (14%), and severe outcomes (12%). Most patients (75%) were asymptomatic, however, there was a higher risk of surgery and severe complications based on the presence of symptoms (P = 0.003). The rate of surgical intervention was higher with ≥3 magnets (31.7%) compared to 2 magnets (2.4%) (P < 0.003). Additionally, we found an 160% increase in children with magnet ingestions in the post-ban period (P = 0.021). Conclusions: Multiple magnet ingestion is associated with high morbidity and rate of severe outcomes. There is a relationship between public policy of magnet sale and frequency of magnet ingestion.
Title: Developmental Differences in Lexical Decision Among Monolingual and Bilingual Children

1.0 Background 2.0 Studies in Vocabulary Acquisition Carried Out in the Netherlands 2.1 Speeding Up The Second Language Vocabulary Acquisition of Minority Children 2.2 Lexical Knowledge in L1 and L2 of Third and Fifth Graders 2.3. The Assessment of Deep Word Knowledge in Young First and Second Language Learners 2.4 Section Conclusion 3.0 Bilingualism 3.1 The Time Factor – Bilingual Mental Lexicon 3.2 The Time Factor – Bilingual Memory 3.2.1. Bilingual Memory – Word Recognition and Lexical Access 3.2.2 Implication of Shared Conceptual Knowledge 4.0 The Experiment 4.1 The Questionnaire 4.2 MRT 4.2.1 The Material 4.2.2 The Procedure 4.3 WAT 4.3.1 The Material 4.3.2 The Procedure 4.4 The Participants 4.5 The Result 4.6 Discussion 5.0 Problems and Recommendations for Future Research 6.0 Conclusion
Prefixed-Time Local Intermittent Sampling Synchronization of Stochastic Multicoupling Delay Reaction–Diffusion Dynamic Networks

This article focuses on the problem of prefixed-time synchronization for stochastic multicoupled delay dynamic networks with reaction–diffusion terms and discontinuous activation by means of local intermittent sampling control. Notably, unlike the existing common fixed-time synchronization, this article puts forward a new synchronization concept, prefixed-time synchronization, based on the fact that stochastic noise and discontinuous activation can be seen everywhere in practical engineering, which can effectively perfect and improve the existing works. Specifically, a local intermittent in the time domain and point sampling control strategy in the spatial domain is proposed instead of a simple single intermittent control approach, which greatly reduces the control cost. In addition, by some effective means, including the famous Young’s inequality, Jensen’s inequality, and Hölder’s inequality, we obtain two different synchronization criteria of the networks without delay and with multicoupling delays and deeply reveal the quantitative relationship among control period, point sampling length, and network scale. Finally, a numerical example is given to verify the effectiveness of the developed method and the practicability by Chua’s circuit model.
Analysis of the saliva metabolic signature in patients with primary Sjögren’s syndrome

Background The saliva metabolome has been applied to explore disease biomarkers. In this study we characterized the metabolic profile of primary Sjögren’s syndrome (pSS) patients and explored metabolomic biomarkers. Methods This work presents a liquid chromatography-mass spectrometry-based metabolomic study of the saliva of 32 patients with pSS and 38 age- and sex-matched healthy adults. Potential pSS saliva metabolite biomarkers were explored using test group saliva samples (20 patients with pSS vs. 25 healthy adults) and were then verified by a cross-validation group (12 patients with pSS vs. 13 healthy adults). Results Metabolic pathways, including tryptophan metabolism, tyrosine metabolism, carbon fixation, and aspartate and asparagine metabolism, were found to be significantly regulated and related to inflammatory injury, neurological cognitive impairment and the immune response. Phenylalanyl-alanine was discovered to have good predictive ability for pSS, with an area under the curve (AUC) of 0.87 in the testing group (validation group: AUC = 0.75). Conclusion Our study shows that salivary metabolomics is a useful strategy for differential analysis and biomarker discovery in pSS.
Delta or Omicron BA.1/2‐neutralizing antibody levels and T‐cell reactivity after triple‐vaccination or infection

Ruben Rose, Franziska Neumann, Sina Müller, Carina Bäumler, Miriam Schäfer, Frieda Schön, Janine Römpke, Simone Schulze, Dirk Weyer, Olaf Grobe, Thomas Lorentz, Helmut Fickenscher, and Andi Krumbholz Universitatsklinikum Schleswig-Holstein Labor Dr Krause und Kollegen MVZ GmbH Steenbeker Weg 23 D-24106 Kiel Germany Stadtisches Krankenhaus Kiel Stadt Flensburg Gesundheitsdienste D-24931 Flensburg Germany