Miracle-dz/UniFAR-FTUs huggingface dataset:
Carbon isotope‐constrained seasonality of carbonaceous aerosol sources from an urban location (Kanpur) in the Indo‐Gangetic Plain

The Indo‐Gangetic Plain (IGP) in northern India, Pakistan, and Bangladesh is a major source of carbonaceous aerosols in South Asia. However, poorly constrained seasonality of their sources over the IGP leads to large uncertainty in climate and health effects. Here we present a first data set for year‐round radiocarbon (Δ14C) and stable carbon (δ13C)‐based source apportionment of total carbon (TC) in ambient PM10 (n = 17) collected from an urban site (Kanpur: 26.5°N, 80.3°E) in the IGP during January 2007 to January 2008. The year‐round 14C‐based fraction biomass (fbio‐TC) estimate at Kanpur averages ~77 ± 7% and emphasizes an impact of biomass burning emissions (BBEs). The highest fbio‐TC (%) is observed in fall season (October–November, 85 ± 6%) followed by winter (December–February, 80 ± 4%) and spring (March–May, 75 ± 8%), while lowest values are found in summer (June–September, 69 ± 2%). Since biomass/coal combustion and vehicular emissions mostly contribute to carbonaceous aerosols over the IGP, we predict δ13CTC (δ13Cpred) over Kanpur using known δ13C source signatures and the measured Δ14C value of each sample. The seasonal variability of δ13Cobs − δ13Cpred versus Δ14CTC together with air mass back trajectories and Moderate Resolution Imaging Spectroradiometer fire count data reveal that carbonaceous aerosols in winter/fall are significantly influenced by atmospheric aging (downwind transport of crop residue burning/wood combustion emissions in the northern IGP), while local sources (wheat residue combustion/vehicular emissions) dominate in spring/summer. Given the large temporal and seasonal variability in sources and emission strength of TC over the IGP, 14C‐based constraints are, thus, crucial for reducing their uncertainties in carbonaceous aerosol budgets in climate models.
Increased antimicrobial resistance against azithromycin during COVID: role of irrational utilization.

Objectives To assess the use of azithromycin during coronavirus disease-2019 pandemic and its impact on antimicrobial resistance in an urban setting. METHODS The retrospective, cross-sectional study was conducted on two different data sets. The first data set was of inpatients (N = 300) during the first wave of COVID 19 i.e. January to December, 2020. Data was collected from tertiary care hospitals in Karachi between October 2021 and November 2022 after approval from the ethics review committee of Ziauddin University, Karachi. Drug utilisation evaluation was done using a structured and validated tool. The treatment protocols were evaluated by comparing against the coronavirus disease-2019 treatment protocol 2020 and the guidelines issued by the Medical Microbiology and Infectious Diseases Society of Pakistan. Second data set comprised of the consumption data (obtained from pharmacies for both inpatients and outpatients) as well as the antimicrobial resistance, (obtained from antibiogram collected from the microbiology departments of the participating hospitals). This data was taken for the period of three years i.e. 2019 (Pre-COVID) to 2021 (Post-first wave of COVID) to establish trends of both consumption and antibiotic resistance. Data was analysed using SPSS 20. RESULTS Of the 300 patients, 207(69%) were males and 93(31%) were females. There were 162(54%) adults with mean age 40.06±10.48 years, followed by 120(40%) geriatrics with mean age 70.37±6.94 years, 18(6%) paediatrics with mean age 13.5±3.60 years. All patients were given Azithromycin empirically followed by culture sensitivity test in 21% cases only. Comparison with COVID treatment protocols revealed the non-compliance of just 3%. However, in case of Community Acquired Pneumonia (CAP), sinusitis, typhoid and urethritis, comparison with MMIDSP guidelines revealed non-compliance of 95%, 22%, 75% and 100% respectively. Moreover, in 11% of patients, it was administered for conditions not recommended by guidelines. Furthermore, the Antibiogram exhibited percent increase in resistance against azithromycin. CONCLUSIONS Enhanced consumption and irrational use of azithromycin during the coronavirus disease-2019 pandemic most likely contributed to increase in antimicrobial resistance.
Toward Smart, Automated Junctional Tourniquets—AI Models to Interpret Vessel Occlusion at Physiological Pressure Points

Hemorrhage is the leading cause of preventable death in both civilian and military medicine. Junctional hemorrhages are especially difficult to manage since traditional tourniquet placement is often not possible. Ultrasound can be used to visualize and guide the caretaker to apply pressure at physiological pressure points to stop hemorrhage. However, this process is technically challenging, requiring the vessel to be properly positioned over rigid boney surfaces and applying sufficient pressure to maintain proper occlusion. As a first step toward automating this life-saving intervention, we demonstrate an artificial intelligence algorithm that classifies a vessel as patent or occluded, which can guide a user to apply the appropriate pressure required to stop flow. Neural network models were trained using images captured from a custom tissue-mimicking phantom and an ex vivo swine model of the inguinal region, as pressure was applied using an ultrasound probe with and without color Doppler overlays. Using these images, we developed an image classification algorithm suitable for the determination of patency or occlusion in an ultrasound image containing color Doppler overlay. Separate AI models for both test platforms were able to accurately detect occlusion status in test-image sets to more than 93% accuracy. In conclusion, this methodology can be utilized for guiding and monitoring proper vessel occlusion, which, when combined with automated actuation and other AI models, can allow for automated junctional tourniquet application.
Runoff and Sediment Yields from Runoff Plots on Chained Pinyon-Juniper Sites in Utah

and 150~cm depths in the woodland is due in part to deeper root penetration by the pinyon and juniper trees. Crested wheatgrass roots are concentrated in the surface 45 cm of soil profile, while juniper and pinyon roots are concentrated in the upper 90 cm of soil profile with sinker roots that penetrate even further. This, combined with a seasonal growth of crested wheatgrass as compared with pinyon and juniper, which may transpire a major part of the year, would contribute to less soil moisture in the woodland. There is no evidence that surface soil moisture conditions have been improved enough on the debris-in-place treatments to affect seedling establishment. It is speculated that young trees missed in the chaining process and also deep-rooted shrub species on debris-in-place treatments may benefit most from increases in soil moisture, especially at soil depths beyond 60 cm. Finally, during the course of this study there was no indication of any excess moisture for eventual deep seepage. Areas similar to the Milford site, which have had springs develop following chaining, are areas that have zones of subsurface flow as a result of snowmelt at elevations above the chaining project. The subsurface flow, which was normally consumed by the pinyon-juniper woodland, is not entirely consumed (transpired) under a grass cover. As a result, springs may develop or increase in flow as a result of the chaining. However, based on this study, the water is apparently not due to on-site additions to soil moisture.
Implementation of computer vision technology based on artificial intelligence for medical image analysis

As one of the branches of machine learning, the deep learning model combined with artificial intelligence is widely used in the field of computer vision technology, and the image recognition field represented by medical image analysis is also developing. Its advantage is that it does not rely on human annotation, and the computer can recognize and process the feature information omitted by human beings during the model training process, so as to achieve or even exceed the accuracy of human processing. Based on the general lack of explain ability caused by the unknown data processing process in the deep model, the existing solutions mainly include the establishment of internal explain ability, attention mechanism interpretation of specific models, and the interpretation of unknowable models represented by LIME. The way to quantitatively assess interpretability is still being explored, especially in the interpretative assessment of both doctors and patients in medical decision-related models, several scales have been proposed for reference. The current research on the application of artificial intelligence deep learning models in medical imaging generally pays more attention to accuracy rather than explain ability, resulting in the lack of explain ability, and thus hindering the practical clinical application of deep learning models. Therefore, the need to analyze the development of medical image analysis in the field of artificial intelligence and computer vision technology, and how to balance accuracy and interpretability to develop deep learning models that both doctors and patients can trust will become the research focus of the industry in the future.
Different Sources of Omega-3 Fatty Acid Supplementation vs. Blood Lipid Profiles—A Study on a Rat Model

Dyslipidemia is a serious condition affecting an increasing number of people, and thus, preventive measures, including supplementation, are being developed. We aimed to compare the effect of linseed oil, its ethyl esters and fish oil supplementation on the serum lipid profiles of rats fed a high-fat diet. Wistar rats were divided into nine groups. Four of them were fed a high-fat diet for the whole experiment, four groups were fed a high-fat diet before the supplementation period and then the control one with supplements, and one was fed a control diet without supplements. The whole experiment lasted 12 weeks. A significant reduction in blood triglycerides, total cholesterol and the LDL fraction was noted in supplemented groups compared to the controls, especially in groups supplemented with ethyl esters of linseed oil and linseed oil compared to fish oil groups. The results were also more beneficial in groups where, in addition to supplementation, there was also a diet change from a high-fat diet to a control diet during the supplementation period. We may conclude that supplementation with omega-3 fatty acids, combined with a healthy diet, may be a good way of preventing or alleviating dyslipidemia.
Effectiveness of corticosteroid injection vs platelet rich plasma (PRP) injection in the treatment of plantar fasciitis

Introduction: Plantar fasciitis is one of the most common causes for inferior heel pain in adults. Many noninvasive and invasive treatment modalities are available for its treatment. Local injection of corticosteroid and Platelet-rich plasma (PRP) is usually used in the treatment of chronic plantar fasciitis not responding to noninvasive conservative treatments. Objectives: To compare the efficacy of local injection of corticosteroids and platelet rich plasma (PRP) in the treatment of plantar fasciitis. Methodology: Patients diagnosed as plantar fasciitis and treated conservatively for at least 3 months and had no response to conservative treatment modalities were involved in this study and randomly allocated into 2 groups of 38 each (Group A and Group B). Patients were treated with local corticosteroid injection in group A and autologous PRP injection in group B. Clinical assessment was done prior to the injection and at 3 weeks and 3 months following the injection, which included visual analog pain scale (VAS), subjective rating using the modified Roles and Maudsley score (MRMS), functional outcome score by the Foot function Index (FFI). Results: The mean age, sex and body mass index was comparable for both groups. Postinjection, there was significant improvement (p < 0.05) of visual analog score (VAS), modified Roles and Maudsley score (MRMS), Foot Function Index in both the groups. However, there was no significant difference (p > 0.05) in improvement of VAS, MRMS and FFI when compared between the 2 groups. Conclusion: This study revealed that the treatment of plantar fasciitis with steroid or PRP injection was equally effective in patients who do not respond to conservative treatment.
On the role of extratropical air‐sea interaction in the persistence of the Southern Annular Mode

Using the daily atmosphere and ocean reanalysis data, this study highlights the role of extratropical air‐sea interaction in the variability of the Southern Annular Mode (SAM). Our analysis shows that the SAM‐induced meridional dipolar sea surface temperature (SST) anomalies, through surface heat fluxes, can maintain persistent lower tropospheric temperature anomalies, which further results in anomalous eddy momentum forcing enhancing the persistence of the SAM. With the Finite Amplitude Wave Activity diagnosis, we illustrate that response of the eddy momentum forcing to SST anomalies can be attributed to changes in both baroclinic processes as baroclinic eddy generation and barotropic processes as wave breaking thus resultant diffusive eddy mixing, with the former confined at high latitudes and the latter strongest at midlatitudes. Spectral analysis further suggests that the above air‐sea interactions are important for bimonthly and longer time scale SAM variations. The dipolar SST pattern may be an indicator for predicting subseasonal and interseasonal variabilities of the SAM.
The Association between Red Meat Consumption and Advanced Colorectal Adenomas in a Population Undergoing a Screening-Related Colonoscopy in Alberta, Canada

Simple Summary In this study, we examined whether different types of red meat, processed and unprocessed, contribute to the development of advanced colorectal adenomas, which can be precursors to cancer. Through examining the diets of 1083 individuals at their initial colonoscopy in Calgary, we assessed the impact of meat intake on the presence of these early cancer indicators. We observed that the total amount of red and processed meat, but not unprocessed meat, was associated with the presence of advanced colorectal adenomas at the time of a screening colonoscopy. Our observations provide preliminary evidence that may contribute to a nuanced understanding of diet’s role in colorectal health. Abstract The association between red meat consumption and colorectal cancer has been rigorously examined. However, a more comprehensive understanding of how the intake of unprocessed red meat contributes to the development of early precancerous colorectal lesions, such as advanced colorectal adenomas (ACRAs), requires further investigation. We examined the associations between different types of red meat intake and ACRAs in a sample population of 1083 individuals aged ≥ 50 years undergoing an initial screening colonoscopy in Calgary, Alberta, Canada. Associations between grams per day of total, processed, and unprocessed red meat from diet history questionnaires and ACRAs were evaluated with multivariable logistic regression models. We also applied cubic spline models fitted with three knots (10th, 50th, and 90th percentiles) to identify potential nonlinear associations. We did not observe a meaningful association between unprocessed red meat intake and the presence of ACRAs. In contrast, for every 10 g/d increase in total and processed meat intake, we observed an increase in the odds of ACRAs at the screening colonoscopy (adjusted odds ratio (OR) = 1.05, 95% [CI = 1.01–1.09], p = 0.04) and (adjusted OR = 1.11, 95% [CI = 1.02–1.20], p = 0.02), respectively. This study highlights the importance of differentiating between types of red meat consumption in the context of dietary risks associated with ACRAs.
Can Erythropoietin Open a Novel Avenue for Periodontal Regeneration?

Introduction: Periodontitis is a dramatic inflammatory disease, representing vigorous interactions between specific causative pathogens and host immune responses resulting in the activation of the destructive inflammatory cascade with the subsequent irreversible destruction of the teeth-supporting apparatus. Aim: This study aims to evaluate the effect of using erythropoietin (EPO) injectable hydrogel, as an additional therapeutic option to scaling and root planing (SRP) in the treatment of stage II periodontitis patients, and to assess its effect on the level of osteocalcin and interleukin (IL)-1β in the gingival crevicular fluid (GCF). Methodology: A total number of 40 patients clinically diagnosed with stage II periodontitis were included. The participants were allocated into two equal groups: study and control groups. Patients in the control group received SRP, while those in the study group received SRP followed by injectable hydrogel containing EPO. Clinical parameters such as plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) were assessed at baseline and two months post treatment. GCF samples were collected at baseline and two months post treatment from both groups to analyze GCF IL-1β and osteocalcin levels using enzyme-linked immunosorbent assay (ELISA). Results: Significant reductions in all tested clinical parameters were revealed in both groups in comparison to baseline values. A marked significant reduction in GCF IL-1β level was detected in the study group. However, two months post treatment, the osteocalcin level was decreased significantly in both groups. Conclusion: This preliminary study shows great promise for the local application of EPO hydrogel as an adjunct to SRP for the management of stage II periodontitis.
Climate and climatic variability of rainfall over eastern Africa

This review examines several aspects of the climate of eastern Africa. The climatic commonality throughout the region is the frequent occurrence of drought severe enough to incapacitate the population. Because of recent droughts and evidence of disastrous, long‐term climatic change, the region has become a major focus of meteorological research. This review covers six relevant topics: climatic regionalization, seasonal cycle, intraseasonal variability, interannual variability, recent trends, and seasonal forecasting. What emerges is a markedly different view of the factors modulating rainfall, the dynamics associated with the seasons, and the character of teleconnections within the region and the interrelationships between the various rainy seasons. Some of the most important points are the following. (1) The paradigm of two rainy seasons resulting from the biannual equatorial passage of the Intertropical Convergence Zone is inadequate. (2) The “long rains” should not be treated as a single season, as character, causal factors, and teleconnections are markedly different in each month. (3) The long rains have been declining continuously in recent decades. (4) The Madden‐Julian Oscillation has emerged as a factor in interannual and intraseasonal variability, but the relative strength of Pacific and Indian Ocean anomalies plays a major role in the downward trend. (5) Factors governing the short rains are nonstationary. (6) Droughts have become longer and more intense and tend to continue across rainy seasons, and their causes are not adequately understood. (7) Atmospheric variables provide more reliable seasonal forecasts than the factors traditionally considered in forecast models, such as sea surface temperatures and El Niño–Southern Oscillation.
Therapeutic Evaluation of Bifidobacterium animalis subsp. lactis MH-02 as an Adjunctive Treatment in Patients with Reflux Esophagitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Proton pump inhibitors (PPIs) are currently routinely used for the treatment of reflux esophagitis (RE); however, with frequent symptom recurrence after discontinuation and limited clinical improvement in accompanying gastrointestinal symptoms. This study aims to explore the adjuvant therapeutic effect of Bifidobacterium supplement for RE patients. A total of 110 eligible RE patients were recruited and randomly assigned to the placebo and probiotic groups. All patients were treated with rabeprazole tablets and simultaneously received either Bifidobacterium animalis subsp. lactis MH-02 or placebo for 8 weeks. Patients who achieved clinical remission then entered the next 12 weeks of follow-up. RDQ, GSRS scores, and endoscopy were performed to assess clinical improvement, and changes in intestinal microbiota were analyzed with high-throughput sequencing. Our results revealed that MH-02 combined therapy demonstrated an earlier time to symptom resolution (50.98% vs. 30.61%, p = 0.044), a significant reduction in the GSRS score (p = 0.0007), and a longer mean time to relapse (p = 0.0013). In addition, high-throughput analyses showed that MH-02 combined therapy increased the α (p = 0.001) diversity of gut microbiota and altered microbial composition by beta diversity analysis, accompanied with significantly altered gut microbiota taxa at the genus level, where the abundance of some microbial genera including Bifidobacterium, Clostridium, and Blautia were increased, while the relative abundance of Streptococcus and Rothia were decreased (p < 0.05). Collectively, these results support the beneficial effects of MH-02 as a novel complementary strategy in RE routine treatment.
Inherited bone marrow failure syndromes: phenotype as a tool for early diagnostic suspicion at a major reference center in Mexico

Introduction: The inherited bone marrow failure syndromes (IBMFSs) are a group of rare disorders characterized by bone marrow failure (BMF), physical abnormalities, and an increased risk of neoplasia. The National Institute of Pediatrics (INP) is a major medical institution in Mexico, where patients with BMF receive a complete approach that includes paraclinical tests. Readily recognizable features, such as the hematological and distinctive physical phenotypes, identified by clinical dysmorphologists, remain crucial for the diagnosis and management of these patients, particularly in circumstances where next-generation sequencing (NGS) is not easily available. Here, we describe a group of Mexican patients with a high clinical suspicion of an IBMFS. Methods: We performed a systematic retrospective analysis of the medical records of patients who had a high IBMFS suspicion at our institution from January 2018 to July 2021. An initial assessment included first ruling out acquired causes of BMF by the Hematology Department and referral of the patient to the Department of Human Genetics for physical examination to search for specific phenotypes suggesting an IBMFS. Patients with high suspicion of having an IBMFS were classified into two main groups: 1) specific IBMFS, including dyskeratosis congenita (DC), Diamond–Blackfan anemia (DBA), Shwachman–Diamond syndrome (SDS), thrombocytopenia with absent radii (TAR), and severe congenital neutropenia (SCN); 2) undefined IBMFS (UI). Results: We established a high suspicion of having an IBMFS in 48 patients. At initial evaluation, the most common hematologic features were bicytopenia (20%) and aplastic anemia (16%); three patients received hematopoietic stem cell transplantation. Among patients with a suspicion of an IBMFS, the most common physical abnormality was minor craniofacial features in 83% of patients and neurodevelopmental disorders in 52%. The specific suspicions that we built were DBA (31%), SDS (18%), DC (14%), TAR (4%), and SCN (4%), whereas 27% of cases remained as undefined IBMFS. SDS, TAR, and SCN were more commonly suspected at an earlier age (<1 year), followed by DBA (2 years) and DC (5 years). Conclusions: Thorough examination of reported clinical data allowed us to highly suspect a specific IBMFS in approximately 70% of patients; however, an important number of patients remained with suspicion of an undefined IBMFS. Implementation of NGS and telomere length measurement are forthcoming measures to improve IBMFS diagnosis in Mexico.