Miracle-dz/UniFAR-FTUs huggingface dataset:
Mental health professionals’ perspectives regarding how recovery is conceptualized in Singapore: a constructivist grounded theory study

Abstract Background Mental health recovery has shifted from clinical conceptualizations to more personal ones. However, much of the lived experience literature has focused on people living with mental health conditions, and less attention has been placed on various mental health professionals, especially in Asian countries, where the personal recovery literature base is in its nascent stage. Aim We sought to contribute to a growing body of work by exploring recovery from the lens of different mental health professionals in Singapore. Methods Mental health professionals in Singapore were invited to participate in an online interview through social media. The recordings were transcribed verbatim and analyzed using a constructive grounded theory approach. Results Nineteen participants were interviewed. A single core category, “living in society once more”, and three categories, “An ongoing process”, “Regaining ability to function in society”, and “A normality report card” were identified from our data. Conclusions Recovery within the Singapore mental health professional perspective focuses on helping individuals return to society and function productively while considering existing societal norms such as the highly competitive and pragmatic culture in Singapore. Future research can explore in greater depth the impact of these factors on the recovery process.
Extreme-Ultraviolet Rocket Spectroscopy of the Hot DA White Dwarf G191-B2B

Because of a lack of spectral resolution in existing spectroscopic data, current white dwarf atmospheric models cannot explain the atmospheric structure, and resultant extreme-ultraviolet (EUV) emission, of G191-B2B unambiguously. Therefore, a new rocket-borne EUV spectrograph was designed, built, calibrated, and launched. This instrument observed G191-B2B over a bandpass of 254-317 Å and with a resolving power of λ/Δλ ≈ 2800. Highly statistically significant absorption features within the flight spectrum, coupled with metal-rich modeled stellar spectra, provide evidence for blended features of Fe IV/Fe V and Fe IV/O III in G191-B2B's atmosphere. A 3 σ upper limit of 2 × 10-5 has been placed on the photospheric helium abundance, arguing against models that rely on He II as a major EUV opacity source.
Delayed rejection in reversible jump Metropolis–Hastings

SUMMARY In a Metropolis-Hastings algorithm, rejection of proposed moves is an intrinsic part of ensuring that the chain converges to the intended target distribution. However, persistent rejection, perhaps in particular parts of the state space, may indicate that locally the proposal distribution is badly calibrated to the target. As an alternative to careful off-line tuning of state-dependent proposals, the basic algorithm can be modified so that, on rejection, a second attempt to move is made. A different proposal can be generated from a new distribution that is allowed to depend on the previously rejected proposal. We generalise this idea of delaying the rejection and adapting the proposal distribution, due to Tierney & Mira (1999), to generate a more flexible class of methods that applies in particular to a variable-dimension setting. The approach is illustrated by two pedagogical examples and a more realistic application to a changepoints analysis for point processes. Some key wor-ds: Adaptive; Changepoint; Efficiency of Markov chain Monte Carlo estimation; Integrated autocorrelation time; Peskun ordering.
Adaptive Filters for Edge Detection

Edge detection in machine vision usually consists of filtering the image with a set of circularly symmetric and/or even and odd symmetric oriented filters covering a range of spatial scales. The filters' responses at each point in the image are then thresholded either before or after being combined in some manner. Selecting functions to combine responses of filters with differing spatial scales, orientations, and symmetries is a major problem with this type of approach, as is choosing appropriate thresholds. Additionally, the computational burden has rendered the approach unfit for most practical image processing systems at this time. A new "constrained matched filter" algorithm is presented which addresses these problems. At each pixel, the algorithm computes a consistency measure and forms a template based on simple measurements of changes in intensity gradient in a small neighbourhood. Consistency is a measure of the localization of gradient changes within the neighbourhood. The location of a possible edge pixel, which need not coincide with the template center, is determined. The template is cross-correlated with the image, and the result is accumulated in an output image at the edge-pixel location previously found. The result image may be thresholded to generate a "line drawing" showing the locations of lines, step edges and roof edges.
The electrodynamic mechanisms of optical binding

The term 'optical binding' conveniently encapsulates a variety of phenomena whereby light can exert a modifying influence on inter-particle forces. The mutual attraction that the 'binding' description suggests is not universal; both attractive and repulsive forces, as well as torques can be generated, according to the particle morphology and optical geometry. Generally, such forces and torques propel particles towards local sites of potential energy minimum, forming the stable structures that have been observed in numerous experimental studies. The underlying mechanisms by means of which such effects are produced have admitted various theoretical interpretations. The most widely invoked explanations include collective scattering, dynamically induced dipole coupling, optically-dressed Casimir-Polder interactions, and virtual photon coupling. By appeal to the framework that led to the first predictions of the effect, based on quantum electrodynamics, it can be demonstrated that many of these apparently distinct representations reflects a different facet of the same fundamental mechanism, leading in each case to the same equations of motion. Further analysis, based on the same framework, also reveals the potential operation of another mechanism, associated with dipolar response to local dc fields that result from optical rectification. This secondary mechanism can engender shifts in the positions of the potential energy minima for optical binding. The effects of multi-particle interactions can be addressed in a theoretical representation that is especially well suited for modeling applications, including the generation of potential energy landscapes.
AGC: compact representation of assembled genomes with fast queries and updates

Abstract Motivation High-quality sequence assembly is the ultimate representation of complete genetic information of an individual. Several ongoing pangenome projects are producing collections of high-quality assemblies of various species. Each project has already generated assemblies of hundreds of gigabytes on disk, greatly impeding the distribution of and access to such rich datasets. Results Here, we show how to reduce the size of the sequenced genomes by 2–3 orders of magnitude. Our tool compresses the genomes significantly better than the existing programs and is much faster. Moreover, its unique feature is the ability to access any contig (or its part) in a fraction of a second and easily append new samples to the compressed collections. Thanks to this, AGC could be useful not only for backup or transfer purposes but also for routine analysis of pangenome sequences in common pipelines. With the rapidly reduced cost and improved accuracy of sequencing technologies, we anticipate more comprehensive pangenome projects with much larger sample sizes. AGC is likely to become a foundation tool to store, distribute and access pangenome data. Availability and implementation The source code of AGC is available at https://github.com/refresh-bio/agc. The package can be installed via Bioconda at https://anaconda.org/bioconda/agc. Supplementary information Supplementary data are available at Bioinformatics online.
Mechanistic insights into spontaneous transition from cellular alternans to ventricular fibrillation

T‐wave alternans (TWA) has been used for predicting the risk of malignant cardiac arrhythmias and sudden cardiac death (SCD) in multiple clinical settings; however, possible mechanism(s) underlying the spontaneous transition from cellular alternans reflected by TWA to arrhythmias in impaired repolarization remains unclear. The healthy guinea pig ventricular myocytes under E‐4031 blocking IKr (0.1 μM, N = 12; 0.3 μM, N = 10; 1 μM, N = 10) were evaluated using whole‐cell patch‐clamp. The electrophysiological properties of isolated perfused guinea pig hearts under E‐4031 (0.1 μM, N = 5; 0.3 μM, N = 5; 1 μM, N = 5) were evaluated using dual‐ optical mapping. The amplitude/threshold/restitution curves of action potential duration (APD) alternans and potential mechanism(s) underlying the spontaneous transition of cellular alternans to ventricular fibrillation (VF) were examined. There were longer APD80 and increased amplitude and threshold of APD alternans in E‐4031 group compared with baseline group, which was reflected by more pronounced arrhythmogenesis at the tissue level, and were associated with steep restitution curves of the APD and the conduction velocity (CV). Conduction of AP alternans augmented tissue's functional spatiotemporal heterogeneity of regional AP/Ca alternans, as well as the AP/Ca dispersion, leading to localized uni‐directional conduction block that spontaneous facilitated the formation of reentrant excitation waves without the need for additional premature stimulus. Our results provide a possible mechanism for the spontaneous transition from cardiac electrical alternans in cellular action potentials and intercellular conduction without the involvement of premature excitations, and explain the increased susceptibility to ventricular arrhythmias in impaired repolarization. In this study, we implemented voltage‐clamp and dual‐optical mapping approaches to investigate the underlying mechanism(s) for the arrhythmogenesis of cardiac alternans in the guinea pig heart at cellular and tissue levels. Our results demonstrated a spontaneous development of reentry from cellular alternans, arising from a combined actions of restitution properties of action potential duration, conduction velocity of excitation wave and interplay between alternants of action potential and the intracellular Ca handling. We believe this study provides new insights into underlying the mechanism, by which cellular cardiac alternans spontaneously evolves into cardiac arrhythmias.
The Distribution of and Access to Free Meal Sites Serving School Aged Children During the COVID-19 Pandemic: Evidence From Texas.

BACKGROUND The COVID-19 pandemic disrupted access to school meal programs, putting children and adolescents at greater risk for food and nutrition insecurity. In response, the US Department of Agriculture (USDA) waived restrictions on where free meal sites (FMS) operating through its summer meal programs could locate. This study assesses whether and how the distribution of FMS across communities and access to them changed after the waiver. METHODS This study used administrative and survey data on all FMS and census tracts in Texas for July 2019, before the waiver, and July 2020, after the waiver. Changes in the characteristics of tracts hosting an FMS and the share within accessible range of a site were evaluated using t-tests. These were supplemented with multilevel conditional logit models linking tract characteristics to the likelihood of hosting an FMS and estimates for the number of children and adolescents with access to an FMS. FINDINGS More FMS were operating after the waiver, and these were spread across a wider range of census tracts. An estimated 213,158 additional children and adolescents gained access to an FMS, including those at highest risk for food and nutrition insecurity. IMPLICATIONS FOR SCHOOL HEALTH POLICY Relaxing restrictions on the location of FMS can expand children and adolescent's access to meals during expected and unexpected disruptions to school meal programs.
Biogenic synthesis of silver nanoparticles using Funaria hygrometrica Hedw. and their effects on the growth of Zea mays seedlings

The biogenic synthesis of silver nanoparticles (AgNPs) is an important step in developing eco‐friendly and environmentally stable tools for ameliorating crop growth. In the current study, AgNPs were synthesized using Funaria hygrometrica and characterized using ultraviolet (UV) spectroscopy, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and X‐ray diffraction (XRD). The UV spectrum showed an absorption peak at 450 nm. SEM revealed an irregular and spherical morphology, FTIR spectroscopy indicated the presence of various functional groups, while XRD displayed peaks at 45.24°, 38.17°, 44.34°, 64.54°, and 57.48° 2θ. The effects of the F. hygrometrica‐mediated AgNPs on maize growth and germination were assessed at 0, 100, 300, and 500 ppm. The germination percentage and relative germination rate were increased to 95% ± 1.83% and 100% ± 2.48% at 100 ppm of synthesized AgNPs and then declined at 300 and 500 ppm. The length, fresh weight, and dry matter of the root, shoot, and seedlings were highest at 100 ppm NPs. The plant height, root length, and dry matter stress tolerance indices were also the highest (112.3%, 118.7%, and 138.20% compared with the control) at 100 ppm AgNPs. Moreover, the growth of three maize varieties, that is, NR‐429, NR‐449, and Borlog, were assessed at 0, 20, 40, and 60 ppm F. hygrometrica‐AgNPs. The results indicated the highest root and shoot length at 20 ppm AgNPs. In conclusion, seed priming with AgNPs enhances the growth and germination of maize and can ameliorate crop production globally.
Coronary Inflammation and Plaque Vulnerability: A Coronary Computed Tomography and Optical Coherence Tomography Study

Background: Vascular inflammation plays a key role in atherogenesis and in the development of acute coronary syndromes. Coronary inflammation can be measured by peri-coronary adipose tissue (PCAT) attenuation on computed tomography angiography. We examined the relationships between the level of coronary artery inflammation assessed by PCAT attenuation and coronary plaque characteristics by optical coherence tomography. Methods: A total of 474 patients (198 acute coronary syndromes and 276 stable angina pectoris) who underwent preintervention coronary computed tomography angiography and optical coherence tomography were included. To compare the relationships between the level of coronary artery inflammation and detailed plaque characteristics, we divided the subjects into high (n=244) and low (n=230) PCAT attenuation groups using a threshold value of −70.1 Hounsfield units. Results: The high PCAT attenuation group, compared with the low PCAT attenuation group, had more males (90.6% versus 69.6%; P<0.001), more non-ST-segment elevation myocardial infarction (38.5% versus 25.7%; P=0.003), and less stable angina pectoris (51.6% versus 65.2%; P=0.003). Aspirin, dual antiplatelet, and statins were less frequently used in the high PCAT attenuation group compared to the low PCAT attenuation group. Patients with high PCAT attenuation, compared with those with low PCAT attenuation, had lower ejection fraction (median 64% versus 65%; P=0.014) and lower levels of high-density lipoprotein cholesterol (median 45 versus 48 mg/dL; P=0.027). Optical coherence tomography features of plaque vulnerability were significantly more common in patients with high PCAT attenuation, compared to those with low PCAT attenuation, including lipid-rich plaque (87.3% versus 77.8%; P=0.006), macrophage (76.2% versus 67.8%; P=0.041), microchannels (61.9% versus 48.3%; P=0.003), plaque rupture (38.1% versus 23.9%; P<0.001), and layered plaque (60.2% versus 50.0%; P=0.025). Conclusions: Optical coherence tomography features of plaque vulnerability were significantly more common in patients with high PCAT attenuation, compared with those with low PCAT attenuation. Vascular inflammation and plaque vulnerability are intimately related in patients with coronary artery disease. Registration: URL: https://www.clinicaltrials. gov; Unique identifier: NCT04523194.
Moving, fast and slow: behavioural insights into bradykinesia in Parkinson’s disease

Abstract The debilitating symptoms of Parkinson’s disease, including the hallmark slowness of movement, termed bradykinesia, were described more than 100 years ago. Despite significant advances in elucidating the genetic, molecular and neurobiological changes in Parkinson’s disease, it remains conceptually unclear exactly why patients with Parkinson’s disease move slowly. To address this, we summarize behavioural observations of movement slowness in Parkinson’s disease and discuss these findings in a behavioural framework of optimal control. In this framework, agents optimize the time it takes to gather and harvest rewards by adapting their movement vigour according to the reward that is at stake and the effort that needs to be expended. Thus, slow movements can be favourable when the reward is deemed unappealing or the movement very costly. While reduced reward sensitivity, which makes patients less inclined to work for reward, has been reported in Parkinson’s disease, this appears to be related mainly to motivational deficits (apathy) rather than bradykinesia. Increased effort sensitivity has been proposed to underlie movement slowness in Parkinson’s disease. However, careful behavioural observations of bradykinesia are inconsistent with abnormal computations of effort costs due to accuracy constraints or movement energetic expenditure. These inconsistencies can be resolved when considering that a general disability to switch between stable and dynamic movement states can contribute to an abnormal composite effort cost related to movement in Parkinson’s disease. This can account for paradoxical observations such as the abnormally slow relaxation of isometric contractions or difficulties in halting a movement in Parkinson’s disease, both of which increase movement energy expenditure. A sound understanding of the abnormal behavioural computations mediating motor impairment in Parkinson’s disease will be vital for linking them to their underlying neural dynamics in distributed brain networks and for grounding future experimental studies in well-defined behavioural frameworks.
Real‐time evaluation of the biocompatibility of calcium silicate‐based endodontic cements: An in vitro study

An ideal filling material should hermetically seal the communication pathways between the canal system and surrounding tissues. Therefore, during the last few years, the development of obturation materials and techniques to create optimal conditions for the proper healing of apical tissues has been a focus of interest. The effects of calcium silicate‐based cements (CSCs) on periodontal ligament cells have been investigated, and promising results have been obtained. To date, there are no reports in the literature that have evaluated the biocompatibility of CSCs using a real‐time live cell system. Therefore, this study aimed to evaluate the real‐time biocompatibility of CSCs with human periodontal ligament cells (hPDLCs).
Independence Number And Degree Bounded Spanning Tree

This paper deals with the classical degree-bounded-spanning-tree problem. We define degree-d-bounded-spanning tree to be a spanning tree having no vertices of degree larger than d. The main result of this paper states that, if G =( V , E) is a connected graph having independence number d ,w hered ≥ 2, then G has a degree-d-bounded spanning tree. Also an O(n 2 ) algorithm for constructing such a spanning tree is presented.
Midfrontal Theta and Cognitive Control During Interlimb Coordination Across the Adult Lifespan

Abstract Interlimb coordination is required for adequate execution of most daily life activities. Yet, aging negatively affects interlimb coordination, impacting the quality of life in older people. Therefore, disentangling the underlying age-related neural mechanisms is of utmost importance. Here, we investigated neurophysiological processes of an interlimb reaction time task, including both simple and complex coordination modes. Midfrontal theta power, measured using electroencephalography (EEG), was analyzed as a marker for cognitive control. In total, 82 healthy adults participated, with 27 younger, 26 middle-aged, and 29 older adults. On a behavioral level, reaction time increased across the adult lifespan, and error rate was higher in older adults. Notably, aging disproportionately affected reaction times in the complex coordination modes, with larger reaction time increases from simple to complex movements than in younger adults, starting already at middle age. On the neurophysiological level, EEG showed that only younger adults had significantly increased levels of midfrontal theta power during complex relative to simple coordination modes, while no significant differences were found between simple and complex movements in middle-aged and older adults. The absence of this theta power upregulation with regard to movement complexity with increasing age might reflect a premature saturation of the available mental resources.
Performance evaluation of a novel 14C-urea breath test (solid scintillation) for the diagnosis of helicobacter pylori infection

14C-urea breath tests (UBTs) can be used to diagnose helicobacter pylori (H. pylori) infection. This study aimed to evaluate the accuracy of a solid scintillation 14C-UBT in diagnosing H pylori infection. This open-label, prospective multicenter study enrolled patients who underwent H pylori screening from January 7, 2020, to October 28, 2020, in 3 centers in China. All participants underwent solid scintillation UBT first and then gastroscopy. The rapid urease test and histological examination results were the gold standards (H pylori-positive was defined as the 2 tests being positive; H pylori-negative was defined as both tests being negative). The solid scintillation 14C-UBT involves a scintillation sampling bottle and a 14C-urea capsule. The sampling bottle contains a stack of carbon dioxide-absorbing and scintillation sheets. The test is read using a photomultiplier. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for H pylori infection were evaluated. This study enrolled 239 participants. There were 98 males and 141 females, aged 45.8 ± 11.9 (range: 21–66) years. Thirty-four participants were excluded due to a discrepancy between the rapid urease test and immunohistochemistry examination. Finally, 205 participants were included in the analysis. According to the gold standard, 87 out of 205 (42.4%) participants were H pylori-positive. Compared with the gold standard, the sensitivity, specificity, accuracy, and positive and negative predictive values of the solid scintillation 14C-UBT were 95.4%, 97.5%, 96.6%, 96.5%, and 96.6% for the solid scintillation UBT, respectively. One participant experienced 1 adverse event (AE) (exacerbation of chronic cholecystitis), and the AE eventually improved by itself. The investigators determined that the AE was unrelated to the study device. The noninvasive solid scintillation 14C-UBT has a high diagnostic value for H pylori infection, comparable to the diagnostic value of the gold standard.
Details our eyes cannot see: Challenges for the analysis of body position during bicycle fitting

La Trobe Rural Health School, La Trobe University, Bendigo, Australia; Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand; Research Group in Sports Biomechanics (GIBD), Department of Physical Education and Sports, Universitat de València, Valencia, Spain; Applied Neuromechanics Research Group, Universidade Federal do Pampa, Uruguaiana, Brazil