Miracle-dz/UniFAR-FTUs huggingface dataset:
Frequency, Risk Factors, and Prognosis of Dehydration in Acute Stroke

Objective: To determine the frequency, risk factors, and impact on the outcome of dehydration after stroke. Methods: In this cross-sectional observational study, we included prospectively and consecutively patients with ischemic and hemorrhagic stroke. The serum Urea/Creatinine ratio (U/C) was calculated at admission and 3 days after the stroke. Dehydration was defined as U/C>80. Patients were treated in accordance with the standard local hydration protocol. Demographic and clinical data were collected. Neurological severity was evaluated at admission according to the NIHSS score; functional outcome was assessed with the modified Rankin scale score (mRS) at discharge and 3 months after the stroke. Unfavorable outcome was defined as mRS > 2. Results: We evaluated 203 patients; 78.8% presented an ischemic stroke and 21.2% a hemorrhagic stroke. The mean age was 73.4 years ±12.9; 51.7% were men. Dehydration was detected in 18 patients (8.9%), nine patients at admission (4.5%), and nine patients (4.5%) at 3 days after the stroke. Female sex (OR 3.62, 95%CI 1.13–11.58, p = 0.03) and older age (OR 1.05, 95%CI 1–1.11, p = 0.048) were associated with a higher risk of dehydration. Dehydration was significantly associated with an unfavorable outcome at discharge (OR 5.16, 95%CI 1.45–18.25, p = 0.011), but the association was not significant at 3 months (OR 2.95, 95%CI 0.83–10.48, p = 0.095). Conclusion: Dehydration is a treatable risk factor of a poor functional outcome after stroke that is present in 9% of patients. Females and elders present a higher risk of dehydration.
Effect of aquaculture-agriculture sewage on the relation between iron and other trace elements content in Venus clam

In coastal systems, concentrations of trace metals in filter feeders such as shellfish may be affected by anthropogenic activities, including agriculture and aquaculture. Shellfish are a good source of iron, but can also be a potential source of toxic elements, such as cadmium and lead, when consumed by humans. The objective of this study was to determine the differences in iron, zinc, copper, manganese, nickel, lead, and cadmium levels in tissue of the clam Chione gnidia collected from a coastal lagoon influenced by agriculture (Lobos) or aquaculture (Tobari), using an atomic absorption spectrophotometer. The relationship of iron with all other trace elements in these organisms was explored using a generalized linear model (GLM). Iron, copper, manganese, and cadmium concentrations were significantly higher in shellfish collected from the coastal lagoon influenced by agriculture, while nickel was significantly higher in shellfish from the lagoon influenced by aquaculture. In these shellfish, cadmium and lead levels were the factors limiting the weekly intake of clam flesh. The GLM model explained 59% of the iron concentration in the Venus clam, suggesting that this element is directly related to zinc and manganese levels, but inversely related to cadmium content in shellfish.
Saturation of Specific Absorption Rate for Soft and Hard Spinel Ferrite Nanoparticles Synthesized by Polyol Process

Spinel ferrite nanoparticles represent a class of magnetic nanoparticles (MNPs) with enormous potential in magnetic hyperthermia. In this study, we investigated the magnetic and heating properties of spinel soft NiFe2O4, MnFe2O4, and hard CoFe2O4 MNPs of comparable sizes (12–14 nm) synthesized by the polyol method. Similar to the hard ferrite, which predominantly is ferromagnetic at room temperature, the soft ferrite MNPs display a non-negligible coercivity (9–11 kA/m) arising from the strong interparticle interactions. The heating capabilities of ferrite MNPs were evaluated in aqueous media at concentrations between 4 and 1 mg/mL under alternating magnetic fields (AMF) amplitude from 5 to 65 kA/m at a constant frequency of 355 kHz. The hyperthermia data revealed that the SAR values deviate from the quadratic dependence on the AMF amplitude in all three cases in disagreement with the Linear Response Theory. Instead, the SAR values display a sigmoidal dependence on the AMF amplitude, with a maximum heating performance measured for the cobalt ferrites (1780 W/gFe+Co), followed by the manganese ferrites (835 W/gFe+Mn), while the nickel ferrites (540 W/gFe+Ni) present the lowest values of SAR. The heating performances of the ferrites are in agreement with their values of coercivity and saturation magnetization.
The Gravitational waves merger time distribution of binary neutron star systems

Binary neutron stars (BNS) mergers are prime sites for $r$-process nucleosynthesis. Their rate determines the chemical evolution of heavy elements in the Milky Way. The merger rate of BNS is a convolution of their birth rate and the gravitational radiation spiral-in delay time. Using the observed population of Galactic BNS we show here that the lifetimes of pulsars in observed BNSs are sufficiently short that the ages of BNSs have little to no effect on the observed merger time distribution. We find that at late times ($t\gtrsim 1$ Gyr) the gravitational wave delay time distribution (DTD) follows the expected $ t^{-1}$. However, a significant excess of rapidly merging systems (between $40-60\%$ of the entire population) is apparent at shorter times. Although the exact shape of the DTD cannot be determined with the existing data, in all models that adequately describe the data we find at least $40\%$ of BNSs with merger times less than 1Gyr. This population of rapid mergers implies a declining deposition rate of $r$-process materials that is consistent with several independent observations of heavy element abundances in the Milky Way. At the same time this population that requires initial binary separations of roughly one solar radius clearly indicates that these binaries had common envelope progenitors. Our results suggest that a significant fraction of future LIGO/Virgo BNS mergers would reside in star forming galaxies.
Detecting the stimulated decay of axions at radio frequencies

Assuming axion-like particles account for the entirety of the dark matter in the Universe, we study the possibility of detecting their decay into photons at radio frequencies. We discuss different astrophysical targets, such as dwarf spheroidal galaxies, the Galactic Center and halo, and galaxy clusters. The presence of an ambient radiation field leads to a stimulated enhancement of the decay rate; depending on the environment and the mass of the axion, the effect of stimulated emission may amplify the photon flux by serval orders of magnitude. For axion-photon couplings allowed by astrophysical and laboratory constraints (and possibly favored by stellar cooling), we find the signal to be within the reach of next-generation radio telescopes such as the Square Kilometer Array.
Treatment effects beyond the mean using GAMLSS

This paper introduces distributional regression, also known as generalized additive models for location, scale and shape (GAMLSS), as a modeling framework for analyzing treatment effects beyond the mean. By relating each parameter of the response distribution to explanatory variables, GAMLSS model the treatment effect on the whole conditional distribution. Additionally, any nonnormal outcome and nonlinear effects of explanatory variables can be incorporated. We elaborate on the combination of GAMLSS with program evaluation methods in economics and provide practical guidance on the usage of GAMLSS by reanalyzing data from the Mexican \textit{Progresa} program. Contrary to expectations, no significant effects of a cash transfer on the conditional inequality level between treatment and control group are found.
Long-Term Encapsulated Nitrate Supplementation Modulates Rumen Microbial Diversity and Rumen Fermentation to Reduce Methane Emission in Grazing Steers

This study investigated the long-term effects (13 months) of encapsulated nitrate supplementation (ENS) on enteric methane emissions, rumen fermentation parameters, ruminal bacteria, and diversity of archaea in grazing beef cattle. We used a total of thirty-two Nellore steers (initial BW of 197 ± 15.3 kg), 12 of which were fitted with rumen cannulas. For 13 months, the animals were maintained in 12 paddocks and fed a concentrate of ground corn, soybean meals, mineral supplements, and urea (URS) or encapsulated nitrate (EN) containing 70 g of EN/100 kg of BW (corresponding to 47 g NO3-/100 kg BW). Encapsulated nitrate supplementation resulted in similar forage, supplement and total DMI values as URS (P > 0.05), but ENS tended to increase (+48 g/d; P = 0.055) average daily weight gain. Daily reductions in methane emissions (-9.54 g or 18.5%) were observed with ENS when expressed as g of CH4/kg of forage dry matter intake (fDMI) (P = 0.037). Lower concentrations of NH3-N and a higher ruminal pH were observed in ENS groups 6 h after supplementation (P < 0.05). Total VFA rumen concentration 6 h (P = 0.009) and 12 h after supplementation with EN resulted in lower acetate concentrations in the rumen (P = 0.041). Steers supplemented with EN had a greater ruminal abundance of Bacteroides, Barnesiella, Lactobacillus, Selenomonas, Veillonella, Succinimonas, Succinivibrio, and Duganella sp. (P < 0.05), but a lower abundance of Methanobrevibacter sp. (P = 0.007). Strong negative correlations were found between daily methane emissions and Proteobacteria, Erysipelotrichaceae, Prevotellaceae, and Roseburia, Kandleria, Selenomonas, Veillonella, and Succinivibrio sp. (P < 0.05) in the rumen of ENS steers. Encapsulated nitrate is a feed additive that persistently affects enteric methane emission in grazing steers, thereby decreasing Methanobrevibacter abundance in the rumen. In addition, ENS can promote fumarate-reducer and lactate-producer bacteria, thereby reducing acetate production during rumen fermentation.
A duality principle for non-convex optimization in $\mathbb{R}^n$

This article develops a duality principle for a class of optimization problems in $\mathbb{R}^n$. The results are obtained based on standard tools of convex analysis and on a well known result of Toland for D.C. optimization. Global sufficient optimality conditions are also presented as well as relations between the critical points of the primal and dual formulations. Finally we formally prove there is no duality gap between the primal and dual formulations in a local extremal context.
Mediation of Extracellular Polymeric Substances in Microbial Reduction of Hematite by Shewanella oneidensis MR-1

Extracellular electron transfer (EET) plays a fundamental role in microbial reduction/oxidation of minerals. Extracellular polymeric substances (EPS) surrounding the cells constitute a matrix that separates the cell’s outer membrane from insoluble minerals and environmental fluid. This study investigated the effects of EPS on EET processes during microbial reduction of hematite by the iron-reducing strain Shewanella oneidensis MR-1 (MR-1). Electrochemical characterization techniques were employed to determine the influence of EPS components on the redox ability of MR-1. Cells with removed EPS exhibited approximately 30% higher hematite reduction than regular MR-1 cells, and produced a current density of 56 μA cm-2, corresponding to 3–4 fold that of regular MR-1. The superior EET of EPS-deprived cells could be attributed to direct contact between outer membrane proteins and hematite surface, as indicated by more redox peaks being detected by cyclic voltammetry and differential pulse voltammetry. The significantly reduced current density of MR-1 cells treated with proteinase K and deoxyribonuclease suggests that the electron transfer capacity across the EPS layer depends mainly on the spatial distribution of specific proteins and electron shuttles. Exopolysaccharides in EPS tend to inhibit electron transfer, however they also favor the attachment of cells onto hematite surfaces. Consistently, the charge transfer resistance of cells lacking EPS was only 116.3 Ω, approximately 44 times lower than that of regular cells (5,139.1 Ω). These findings point to a negative influence of EPS on EET processes for microbial reduction/oxidation of minerals.
Sterol Regulatory Element-Binding Protein (Sre1) Promotes the Synthesis of Carotenoids and Sterols in Xanthophyllomyces dendrorhous

Xanthophyllomyces dendrorhous is a basidiomycete yeast that synthesizes carotenoids, mainly astaxanthin, which are of great commercial interest. Currently, there are many unknown aspects related to regulatory mechanisms on the synthesis of carotenoids in this yeast. Our recent studies showed that changes in sterol levels and composition resulted in upregulation of genes in the mevalonate pathway required for the synthesis of carotenoid precursors, leading to increased production of these pigments. Sterol Regulatory Element-Binding Proteins (SREBP), called Sre1 in yeast, are conserved transcriptional regulators of sterol homeostasis and other cellular processes. Given the results linking sterols and carotenoids, we investigated the role of SREBP in sterol and carotenoid synthesis in X. dendrorhous. In this study, we present the identification and functional characterization of the X. dendrorhous SRE1 gene, which encodes the transcription factor Sre1. The deduced protein has the characteristic features of SREBP/Sre1 and binds to consensus DNA sequences in vitro. RNA-seq analysis and chromatin-immunoprecipitation experiments showed that genes of the mevalonate pathway and ergosterol biosynthesis are directly regulated by Sre1. The sre1- mutation reduced sterol and carotenoid production in X. dendrorhous, and expression of the Sre1 N-terminal domain (Sre1N) increased carotenoid production more than twofold compared to wild-type. Overall, our results indicate that in X. dendrorhous transcriptional regulation of genes in the mevalonate pathway control production of the isoprenoid derivatives, carotenoids and sterol. Our results provide new insights into the conserved regulatory functions of SREBP/Sre1 and identify pointing to the SREBP pathway as a potential target to enhance carotenoid production in X. dendrorhous.
Eye-tracking study of the celebrity effect on microblogging browsing: an example from Sina microblog

ABSTRACT In this study, 89 college students were selected as research participants and the eye-tracking method was used to explore their browsing patterns and cognitive processing mechanisms for microblogging pages of celebrities and non-celebrities. Results showed that participants were more interested in the microblogging pages of celebrities than non-celebrities. Different types of participants had different cognitive processing strategies for microblogging pages: frequent bloggers used top-down processing methods to process the microblogging pages and infrequent bloggers used bottom-up methods for more sophisticated processing. Participants also had different degrees of cognitive processing for different regions of the microblogging pages. All participants gave priority to the processing of microblog contents, but the processing of celebrity microblog pages showed the dominant effect of profile picture, and the priority of blogger information was revealed in the processing of non-celebrity microblogs.
Surrogate model of hybridized numerical relativity binary black hole waveforms

Numerical relativity (NR) simulations provide the most accurate binary black hole gravitational waveforms, but are prohibitively expensive for applications such as parameter estimation. Surrogate models of NR waveforms have been shown to be both fast and accurate. However, NR-based surrogate models are limited by the training waveforms’ length, which is typically about 20 orbits before merger. We remedy this by hybridizing the NR waveforms using both post-Newtonian and effective one-body waveforms for the early inspiral. We present NRHybSur3dq8, a surrogate model for hybridized nonprecessing numerical relativity waveforms, that is valid for the entire LIGO band (starting at 20 Hz) for stellar mass binaries with total masses as low as 2.25 M⊙. We include the l ≤ 4 and (5, 5) spin-weighted spherical harmonic modes but not the (4, 1) or (4, 0) modes. This model has been trained against hybridized waveforms based on 104 NR waveforms with mass ratios q ≤ 8, and |χ_(1z)|,|χ_(2z)| ≤ 0.8, where χ_(1z) (χ_(2z)) is the spin of the heavier (lighter) black hole in the direction of orbital angular momentum. The surrogate reproduces the hybrid waveforms accurately, with mismatches ≲ 3×10^(−4) over the mass range 2.25 M⊙ ≤ M ≤ 300 M⊙. At high masses (M ≳ 40 M⊙), where the merger and ringdown are more prominent, we show roughly 2 orders of magnitude improvement over existing waveform models. We also show that the surrogate works well even when extrapolated outside its training parameter space range, including at spins as large as 0.998. Finally, we show that this model accurately reproduces the spheroidal-spherical mode mixing present in the NR ringdown signal.
Type II Restriction of Bacteriophage DNA With 5hmdU-Derived Base Modifications

To counteract bacterial defense systems, bacteriophages (phages) make extensive base modifications (substitutions) to block endonuclease restriction. Here we evaluated Type II restriction of three thymidine (T or 5-methyldeoxyuridine, 5mdU) modified phage genomes: Pseudomonas phage M6 with 5-(2-aminoethyl)deoxyuridine (5-NedU), Salmonella phage ViI (Vi1) with 5-(2-aminoethoxy)methyldeoxyuridine (5-NeOmdU) and Delftia phage phi W-14 (a.k.a. ΦW-14) with α-putrescinylthymidine (putT). Among >200 commercially available restriction endonucleases (REases) tested, phage M6, ViI, and phi W-14 genomic DNAs (gDNA) show resistance against 48.4, 71.0, and 68.8% of Type II restrictions, respectively. Inspection of the resistant sites indicates the presence of conserved dinucleotide TG or TC (TS, S=C, or G), implicating the specificity of TS sequence as the target that is converted to modified base in the genomes. We also tested a number of DNA methyltransferases (MTases) on these phage DNAs and found some MTases can fully or partially modify the DNA to confer more resistance to cleavage by REases. Phage M6 restriction fragments can be efficiently ligated by T4 DNA ligase. Phi W-14 restriction fragments show apparent reduced rate in E. coli exonuclease III degradation. This work extends previous studies that hypermodified T derived from 5hmdU provides additional resistance to host-encoded restrictions, in parallel to modified cytosines, guanine, and adenine in phage genomes. The results reported here provide a general guidance to use REases to map and clone phage DNA with hypermodified thymidine.
Acute type A aortic intramural hematoma and type A aortic dissection: correlation between the intimal tear features and pathogenesis.

Background To determine the prevalence, clinical and imaging features of intimal tear detected by ECG-gated multidetector computed tomography (MDCT) and confirmed by surgery in patients with acute type A intramural hematoma (ATAIMH) and acute type A aortic dissection (AAAD). Methods This retrospective study involved analysis of the intimal tear characteristics in 72 consecutive patients with ATAIMH and 209 with AAAD who were diagnosed by MDCT. The size and location of the intimal tear were measured and compared between these two groups of patients. The findings were also compared with those from 28 patients with ATAIMH who underwent surgical treatment to determine the intimal tear features as observed on CT angiography (CTA). Results Patients in the ATAIMH group were significantly older than those in the AAAD group (58.6±11.3 vs. 49.4±12.8 years, P<0.001), and females were predominant in the former category (ATAIMH vs. AAAD: 44.4% vs. 27.8%, P<0.01). Marfan syndrome and pregnancy were associated with most of the occurrences of AAAD. Sixty-four patients (88.9%) with ATAIMH were recognized as having intimal tear in the CTA images. The number of aortic segments in the ATAIMH patients was smaller than that in the AAAD patients (4.45±1.56 vs. 5.04±1.72 segments, P<0.01). The distribution of the intimal tear did not show any difference between the two groups. During the surgery, pericardial hemorrhage was observed in a higher proportion of patients in the ATAIMH than in the AAAD group (60.7% vs. 22.1%; P<0.01). In the former category, all of the intimal tears detected using CTA were confirmed during the operation, and the size was significantly larger than measured on the CTA images (6.95±5.12 vs. 19.59±6.51 mm, P<0.001). Six ATAIMH patients progressed to classical aortic dissection (AD) at surgery. Conclusions Patients with ATAIMH have a high prevalence of intimal tear, which is significantly smaller than that measured in patients with classic AAAD. Just like AD, ATAIMH may also be triggered by intimal tear. Hence, timely surgical repair is needed.
Marginal adaptation of different hybrid ceramic inlays after thermal cycling

The aim of the study was to evaluate the marginal adaptation of various hybrid ceramics inlays before and after thermal cycling. Twenty-four extracted human molars were received inlay preparation, and randomly divided into three groups (n = 8/group). Specimens were restored with Ceramage by experienced technician, Enamic or Lava Ultimate by CAD/CAM using CEREC Omnicam. After cementation, all restorations were subjected to thermal cycling. Marginal gaps were measured under a stereomicroscope. The overall mean marginal gaps of the three groups were significantly different (p < 0.05) before thermal cycling, which were all within the clinically acceptable range. The digital intraoral impression and CAD/CAM systems did not show superior accuracy compared to the traditional technique, during the hybrid ceramic inlays manufactured operation. Thermal cycling had no effect on marginal adaptation of the different hybrid ceramic inlays (p > 0.05). Gingival margin presented larger gaps compared to occlusal and axial margin in all hybrid ceramic inlays.
Network Slimming by Slimmable Networks: Towards One-Shot Architecture Search for Channel Numbers

We study how to set channel numbers in a neural network to achieve better accuracy under constrained resources (e.g., FLOPs, latency, memory footprint or model size). A simple and one-shot solution, named AutoSlim, is presented. Instead of training many network samples and searching with reinforcement learning, we train a single slimmable network to approximate the network accuracy of different channel configurations. We then iteratively evaluate the trained slimmable model and greedily slim the layer with minimal accuracy drop. By this single pass, we can obtain the optimized channel configurations under different resource constraints. We present experiments with MobileNet v1, MobileNet v2, ResNet-50 and RL-searched MNasNet on ImageNet classification. We show significant improvements over their default channel configurations. We also achieve better accuracy than recent channel pruning methods and neural architecture search methods. Notably, by setting optimized channel numbers, our AutoSlim-MobileNet-v2 at 305M FLOPs achieves 74.2% top-1 accuracy, 2.4% better than default MobileNet-v2 (301M FLOPs), and even 0.2% better than RL-searched MNasNet (317M FLOPs). Our AutoSlim-ResNet-50 at 570M FLOPs, without depthwise convolutions, achieves 1.3% better accuracy than MobileNet-v1 (569M FLOPs). Code and models will be available at: this https URL