Miracle-dz/UniFAR-FTUs huggingface dataset:
Article title: Transcriptional profiling efficacy to define biological activity similarity for cosmetic ingredients’ safety assessment based on next-generation read-across

The objective of this work was to use transcriptional profiling to assess the biological activity of structurally related chemicals to define their biological similarity and with that, substantiate the validity of a read-across approach usable in risk assessment. Two case studies are presented, one with 4 short alkyl chain parabens: methyl (MP), ethyl (EP), butyl (BP), and propylparaben (PP), as well as their main metabolite, p-hydroxybenzoic acid (pHBA) with the assumption that propylparaben was the target chemical; and a second one with caffeine and its main metabolites theophylline, theobromine and paraxanthine where CA was the target chemical. The comprehensive transcriptional response of MCF7, HepG2, A549 and ICell cardiomyocytes was evaluated (TempO-Seq) after exposure to vehicle-control, each paraben or pHBA, CA or its metabolites, at 3 non-cytotoxic concentrations, for 6 h. Differentially expressed genes (FDR ≥0.05, and fold change ±1.2≥) were identified for each chemical, at each concentration, and used to determine similarities. Each of the chemicals is able to elicit changes in the expression of a number of genes, as compared to controls. Importantly, the transcriptional profile elicited by each of the parabens shares a high degree of similarity across the group. The highest number of genes commonly affected was between butylparaben and PP. The transcriptional profile of the parabens is similar to the one elicited by estrogen receptor agonists, with BP being the closest structural and biological analogue for PP. In the CA case, the transcriptional profile elicited of all four methylxanthines had a high degree of similarity across the cell types, with CA and theophylline being the most active. The most robust response was obtained in the cardiomyocytes with the highest transcriptional profile similarity between CA and TP. The transcriptional profile of the methylxanthines is similar to the one elicited by inhibitors of phosphatidylinositol 3-kinase as well as other kinase inhibitors. Overall, our results support the approach of incorporating transcriptional profiling in well-designed in vitro tests as one robust stream of data to support biological similarity driven read-across procedures and strengthening the traditional structure-based approaches useful in risk assessment.
Terahertz wave detection performance of photoconductive antennas: Role of antenna structure and gate pulse intensity

We studied the receiver performance of two photoconductive antennas (bow tie and dipole antennas) fabricated on the same low-temperature-grown GaAs substrate to clarify the effect of the antenna structure and gate pulse intensity on terahertz wave detection. We observed the gate pulse intensity dependence of the temporal profiles of the terahertz waves or terahertz spectra. For both antennas, the sensitivity in the low-frequency regime (<0.5THz) was enhanced compared to that in the high-frequency regime for large gate pulse intensities. This is because the carrier trap time increased due to the saturation of the GaAs defect levels. We also observed that the peak-to-peak amplitude of the terahertz wave detected by one antenna was not always larger than that detected by the other antenna, and the peak-to-peak amplitude of the bow tie antenna was larger (smaller) than that of the dipole antenna when the gate pulse intensity was high (low). This was explained by the gate pulse intensity dependence of the freq.
The calcium cyanamide and polyethylene blocks the secondary transmission and infection of vegetable leaf diseases

Continuous cropping obstacles, especially soil-borne diseases can cause serious harm to agricultural production and limit the sustainable development of modern agriculture. However, Corynespora blight is an important air-borne disease on cucumber leaves caused by Corynespora cassiicola. The pathogen also could survive in air-dried soil or plant residue for at least one month. However, it is not clear whether soil Corynespora blight residues can infect plants. We detected the dynamic change of C. cassiicola content in soil and air after returning the diseased and residual straw to the field in real time by PMA-qPCR detection method. In this study, we reveal for the first time a new mode of transmission in which leaf blade disease residues in soil can spread again into the air and infect plants. In polyethylene (PE) treatment, cucumber plants grew healthily without disease. However, the content of C. cassiicola in the soil still existed in the PE treatment at 103 spore·g−1. The disease index (DI) of cucumber was less than 3 in calcium cyanamide (CaCN2). After fumigation and film removal and the whole growth period was controlled at a safe level. In addition, the PMA-qPCR detection method of Corynespora blight of cucumber was established for the first time in this study. In summary, CaCN2 and PE treatments are effective ways to block the infection of cucumber leaves by Corynespora blight residues in soil. These treatments are considered to comprise a feasible and sustainable technique for vegetable leaf residues in greenhouses.
Influencing factors of cancer prevention and control among urban and rural adults in Fujian, China: A cross-sectional survey

Objective Cancer burden can be reduced when the population's knowledge of cancer prevention and control measures is increased. However, current epidemiological research investigating cancer prevention and control knowledge in China is limited. This study aimed to examine the core knowledge levels of cancer prevention and control measures as well as its influencing factors among adults in Fujian, China. Study design A cross-sectional study. Methods From September to December 2021, a total of 2,440 Chinese urban and rural adults from Fujian Province, located in Southeastern China, were randomly selected for this cross-sectional study. The probability proportionate approach to sampling was used. A 38-item questionnaire that covered demographics and basic knowledge of cancer, including concepts, screening, therapy, and rehabilitation-related key points was used to measure knowledge levels of cancer prevention and control measures among 2,074 participants. The level of each participants' core knowledge of cancer prevention and control measures was defined as a rate calculated by the number of correct answers divided by the total number of questions. The binary logistic regression model was used to determine if influencing factors were associated with core knowledge awareness. Results In total, 1,290 participants (62.2%) were in the low knowledge group and 784 (37.8%) were in the high knowledge group. The average knowledge rate of cancer prevention and control measures among all participants was 56.01%. Participants from urban areas, who held white-collar jobs, were married, had a bachelor's degree or above, had a family history of cancer, or self-rated their health level as good or average were associated with higher rates of cancer prevention and control core knowledge (overall p < 0.05). Conclusion These findings may assist healthcare providers and/or researchers in designing effective primary preventive interventions to enhance the general population's cancer prevention and control knowledge, and subsequently decrease the cancer burden in China.
The dynamical stability of differentially rotating discs with constant specific angular momentum

Etude de la stabilite dynamique d'un disque de fluide d'entropie uniforme et de moment angulaire specifique uniforme en rotation differentielle. Un tel fluide est stable neutralement aux perturbations a symetrie axiale. On considere ici des perturbations sans symetrie axiale et on entreprend une analyse de stabilite globale
Construction of prediction model of inflammation related genes in idiopathic pulmonary fibrosis and its correlation with immune microenvironment

Background The role of inflammation in the formation of idiopathic pulmonary fibrosis (IPF) has gained a lot of attention recently. However, the involvement of genes related to inflammation and immune exchange environment status in the prognosis of IPF remains to be further clarified. The objective of this research is to establish a new model for the prediction of the overall survival (OS) rate of inflammation-related IPF. Methods Gene Expression Omnibus (GEO) was employed to obtain the three expression microarrays of IPF, including two from alveolar lavage fluid cells and one from peripheral blood mononuclear cells. To construct the risk assessment model of inflammation-linked genes, least absolute shrinkage and selection operator (lasso), univariate cox and multivariate stepwise regression, and random forest method were used. The proportion of immune cell infiltration was evaluated by single sample Gene Set Enrichment Analysis (ssGSEA) algorithm. Results The value of genes linked with inflammation in the prognosis of IPF was analyzed, and a four-genes risk model was constructed, including tpbg, Myc, ffar2, and CCL2. It was highlighted by Kaplan Meier (K-M) survival analysis that patients with high-risk scores had worse overall survival time in all training and validation sets, and univariate and multivariate analysis highlighted that it has the potential to act as an independent risk indicator for poor prognosis. ROC analysis showed that the prediction efficiency of 1-, 3-, and 5-year OS time in the training set reached 0.784, 0.835, and 0.921, respectively. Immune infiltration analysis showed that Myeloid-Derived Suppressor Cells (MDSC), macrophages, regulatory T cells, cd4+ t cells, neutrophils, and dendritic cells were more infiltrated in the high-risk group than in the low-risk group. Conclusion Inflammation-related genes can be well used to evaluate the IPF prognosis and impart a new idea for the treatment and follow-up management of IPF patients.
Autophagy modulates growth and development in the moss Physcomitrium patens

Physcomitrium patens apical growing protonemal cells have the singularity that they continue to undergo cell divisions as the plant develops. This feature provides a valuable tool to study autophagy in the context of a multicellular apical growing tissue coupled to development. Herein, we showed that the core autophagy machinery is present in the moss P. patens, and characterized the 2D and 3D growth and development of atg5 and atg7 loss-of-function mutants under optimal and nutrient-deprived conditions. Our results showed that 2D growth of the different morphological and functional protonemata apical growing cells, chloronema and caulonema, is differentially modulated by this process. These differences depend on the protonema cell type and position along the protonemal filament, and growth condition. As a global plant response, the absence of autophagy favors the spread of the colony through protonemata growth at the expense of a reduction of the 3D growth, such as the buds and gametophore development, and thus the adult gametophytic and reproductive phases. Altogether this study provides valuable information suggesting that autophagy has roles during apical growth with differential responses within the cell types of the same tissue and contributes to life cycle progression and thus the growth and development of the 2D and 3D tissues of P. patens.
The size dependence of the diamond-graphite transition

The transition between nanometre-scaled diamond and graphite as well as the corresponding thermodynamic functions are discussed based on the temperature-pressure phase diagram of carbon including the contribution due to surface effects. As a result, the equilibrium transition size between diamond and graphite as a function of temperature and the thermodynamic function for the transition are obtained. It is found that as the size and temperature decrease, diamond becomes more stable than graphite. The obtained result is consistent with the reported experimental results on the chemical vapour synthesis of nanometre-sized diamond under ambient pressure.
CRISPR/Cas9 based mlo-mediated resistance against Podosphaera xanthii in cucumber (Cucumis sativus L.)

Powdery mildews (PM) are common and severe pathogen groups that threaten plants, and PM resistance is complex and polygenic in cucumbers. Previously mlo-based resistance was reported in various plants, including cucumber, with generated loss-of CsaMLO function mutants. However, mlo-based resistance in cucumber is also complex and involves additional mechanisms such as hypersensitive response (HR) and papillae formation. For this reason, we focused on determining the mlo-based powdery mildew resistance mechanism in cucumber. CRISPR/Cas9 was used in the present study to generate loss-of-function mutants for CsaMLO1, CsaMLO8, and CsaMLO11 of PM susceptible ADR27 cucumber inbred lines and CsaMLO mutants were obtained and validated. Trypan Blue and DAB staining were performed to detect Podosphaera xanthii germination/penetration rates and accumulation of Reactive Oxygen Species (ROS). Our results indicate that PM-susceptibility associated CsaMLOs in cucumber are negative regulators in different defense mechanisms against powdery mildew at early and late stages of infection. Further, the experiment results indicated that CsaMLO8 mutation-based resistance was associated with the pre-invasive response, while CsaMLO1 and CsaMLO11 could be negative regulators in the post-invasive defense response in cucumber against P. xanthii. Although the loss-of CsaMLO8 function confers the highest penetration resistance, CsaMLO1 and CsaMLO11 double mutations could be potential candidates for HR-based resistance against PM pathogen in cucumber. These results highlighted the crucial role of CRISPR/Cas9 to develop PM resistant cucumber cultivars, possessing strong pre-invasive defense with CsaMLO8 or post-invasive with CsaMLO1/CsaMLO11 mutations.
Bipolar spectrum disorders in neurologic disorders

Psychiatric symptoms frequently predate or complicate neurological disorders, such as neurodegenerative diseases. Symptoms of bipolar spectrum disorders (BSD), like mood, behavioral, and psychotic alterations, are known to occur – individually or as a syndromic cluster – in Parkinson’s disease and in the behavioral variant of frontotemporal dementia (FTD). Nonetheless, due to shared pathophysiological mechanisms, or genetic predisposition, several other neurological disorders show significant, yet neglected, clinical and biological overlaps with BSD like neuroinflammation, ion channel dysfunctions, neurotransmission imbalance, or neurodegeneration. BSD pathophysiology is still largely unclear, but large-scale network dysfunctions are known to participate in the onset of mood disorders and psychotic symptoms. Thus, functional alterations can unleash BSD symptoms years before the evidence of an organic disease of the central nervous system. The aim of our narrative review was to illustrate the numerous intersections between BSD and neurological disorders from a clinical-biological point of view and the underlying predisposing factors, to guide future diagnostic and therapeutical research in the field.
Digital technologies and data-driven delay management process for construction projects

One of the main challenges of construction projects is managing delays; there is still a lot to overcome to reach near-zero delays (mitigation of delays) in all construction projects. Technology and different platforms are applied to support a high volume of data flow acquired from multiple resources during the construction project life cycle; how can these automated and digital progress tracking systems be considered for more effective construction delay management? The aim is to investigate the current state of real-time technologies and their applications and assess how specific attributes of these disruptive technologies can significantly alter delay management in construction industries. Therefore, this study presents a new process-based framework for using technologies with a data lifecycle viewpoint. This research uses a four-step systematic literature review involving identification, screening, extortion-eligibility check, and selection-inclusion. Furthermore, it is followed up by a thematic content analysis on using new technologies to mitigate delays in construction projects. Key trends, themes, areas of concern for research, and limitations identified in previous literature as research gaps and future needs were documented and structured. This work presents a novel process of comprehensive classification of real-time technologies that are being used in the construction industry to acquire data, screen/analyses data, and present information through an Industry 4.0 application: IoT technologies such as sensors, RFID etc., smartphones, planning/scheduling tools (Ms Project, Primavera), and Building Information Modelling (BIM). The developed process-based framework is served as a roadmap to 1) centralise real-time communication between technologies to collect, analysis and presentation data in construction phase, 2) prepare timely reports for project managers to take proper action against those problems delaying project.
Where is the limit for overtime? Impacts of overtime on employees’ mental health and potential solutions: A qualitative study in China

Although Labor Law of the People’s Republic of China stipulates the overtime system, overtime is still widespread in the IT industry. Through qualitative interviews, we explored the impact of overtime on employees’ mental health and life. The current study identified four main themes, namely overtime reasons, outcomes of overtime, influential factors and solutions to overtime challenges. Besides work-related reasons and cultural influence, it was found that employees may work overtime due to personal reasons, such as capability and personal qualities; the most frequent impacts reported were fatigue, depression, stress and interference with life; three predominant influential factors were timing of overtime, control and rewards; and overtime conditions could be improved in practical and emotional ways. The study’s findings highlight the importance of the design of flexible working time arrangements for avoiding fatigue and improving employees’ work-life balance, enhancement of schedule arrangement for avoiding daily work interruption and last-minute tasks, and optimization of rewarding systems for avoiding complaints and facilitating voluntary overtime. Results suggest that mental health and work-life balance can be promoted by organizational initiatives focusing on minimizing excessive job demands, increasing psychosocial resources, supporting boundary management, and enhancing perceived flexibility.
Can visual language convey tactile experience? A study of the tactile compensation effect of visual language for online products

Introduction There is a common phenomenon of tactile missing in online retail. How to realize consumer tactile compensation is a consensus problem in the field of e-commerce. More and more marketeers and scholars convey their ideas via visual display, but few researches have focused on the tactile compensatory effect of visual language. Methods Study 1 collected data from nearly 13,000 online purchases to analyze the impact of haptic cues on sales in real online shopping platforms; Study 2 used a experimental research method to design three experimental groups: hand haptic cue group vs. Object haptic cue group vs. control group (N = 165) to investigate whether the main effect of haptic cues and the dual mediating effect of mental simulation held. Study 3 also adopted a simulated experimental research approach to design a two-factor group: 2 (haptic cue: hand vs. object) × 2 (product type: tactile functional product vs. tactile experiential product) (N = 198). To further explore whether the moderating effect of product type holds based on Study 2. Results Therefore, based on the visualization theory and mental simulation theory, and through a second-hand data experiment and two simulated experiments, this study confirmed that visual language did have a compensation effect on tactile missing specifically. Haptic cues in metaphorical visual language can actively compensate for consumers’ tactile loss, thus affecting the purchase intention. Mental simulation plays a mediating role in the tactile compensation effect. Product type has a moderating effect, and the use of hand (object) haptic cues in metaphorical visual language in tactile functional products (tactile experiential products) can lead to a more active purchase intention. Discussion This study not only enriches the theoretical research on the tactile compensation effect of visual language, but also provides valuable management enlightenment for e-commerce enterprises to improve the effectiveness of online product display and online sensory marketing strategies.
Large time behavior of solutions to a semilinear hyperbolic system with relatxaion

We are concerned with the initial value problem for a damped wave equation with a nonlinear convection term which is derived from a semilinear hyperbolic system with relaxation. We show the global existence and asymptotic decay of solutions in W1,p (1 ≤ p ≤ ∞) under smallness condition on the initial data. Moreover, we show that the solution approaches in W1,p (1 ≤ p ≤ ∞) the nonlinear diffusion wave expressed in terms of the self-similar solution of the Burgers equation as time tends to infinity. Our results are based on the detailed pointwise estimates for the fundamental solutions to the linearlized equation.
Anabolic–androgenic steroids: How do they work and what are the risks?

Anabolic–androgenic steroids (AAS) are a class of hormones that are widely abused for their muscle-building and strength-increasing properties in high, nontherapeutic, dosages. This review provides an up-to-date and comprehensive overview on how these hormones work and what side effects they might elicit. We discuss how AAS are absorbed into the circulation after intramuscular injection or oral ingestion and how they are subsequently transported to the tissues, where they will move into the extravascular compartment and diffuse into their target cells. Inside these cells, AAS can biotransform into different metabolites or bind to their cognate receptor: the androgen receptor. AAS and their metabolites can cause side effects such as acne vulgaris, hypertension, hepatotoxicity, dyslipidemia, testosterone deficiency, erectile dysfunction, gynecomastia, and cardiomyopathy. Where applicable, we mention treatment options and self-medication practices of AAS users to counteract these side effects. Clinicians may use this review as a guide for understanding how AAS use can impact health and to assist in patient education and, in some cases, the management of side effects.