Miracle-dz/UniFAR-FTUs huggingface dataset:
Boron‐dependent regulation of translation through AUGUAA sequence in yeast

Under high boron (B) conditions, nodulin 26‐like intrinsic protein 5;1 (NIP5;1) mRNA, a boric acid channel, is destabilized to avoid excess B entry into roots of Arabidopsis thaliana. In this regulation, the minimum upstream open reading frame (uORF), AUGUAA, in its 5′‐untranslated region (5′‐UTR) is essential, and high B enhances ribosome stalling at AUGUAA and leads to suppression of translation and mRNA degradation. This B‐dependent AUGUAA‐mediated regulation occurs also in animal transient expression and reticulocyte lysate translation systems. Thus, uncovering the ubiquitousness of B‐dependent unique regulation is important to reveal the evolution of translational regulation. In the present study, we examined the regulation in Saccharomyces cerevisiae. Reporter assay showed that in yeast, carrying ATGTAA in 5′‐UTR of NIP5;1 upstream of the reporter gene, the relative reporter activities were reduced significantly under high B conditions compared with control, whereas deletion of ATGTAA abolished such responses. This suggests that AUGUAA mediates B‐dependent regulation of translation in Saccharomyces cerevisiae. Moreover, the deletion of ATGTAA resulted in up to 10‐fold increase in general reporter activities indicating the suppression effect of AUGUAA on translation of the main ORF. Interestingly, mRNA level of the reporter gene was not affected by B in both yeast cells with and without AUGUAA. This finding reveals that in yeast, unlike the case in plants, mRNA degradation is not associated with AUGUAA regulation. Together, results suggest that B‐dependent AUGUAA‐mediated translational regulation is common among eukaryotes.
Exploring the Learning Process of Experienced Teachers Focused on Building Positive Interactions with Pupils

ABSTRACT This work investigated the processes of teacher informal learning focused on building positive teacher–pupil interaction. The conceptual framework “Teacher professional agency for learning” was merged with the “Teaching through interaction” model to compound the exploratory framework of this study: Teachers learn by interacting. Teachers first reported their professional agency through a survey. Next, five high scoring teachers were selected for interview. Final participants accounted being motivated and confident of improving their relationships with pupils and reported using diverse learning strategies to improve teacher–pupil interactions. The teachers revealed the need to be authentic to build positive relationships with pupils. This study contributes to the area of teacher learning by addressing transferable strategies that support everyday teacher practices and professional development.
A novel archosauromorph from Antarctica and an updated review of a high-latitude vertebrate assemblage in the wake of the end-Permian mass extinction

Abstract Triassic-aged fossil vertebrates have been sporadically collected from the Fremouw Formation, central Transantarctic Mountains, since their initial discovery in the late 1960s, giving paleontologists insight into high-latitude faunas in the wake of the end-Permian mass extinction event. On a recent expedition (2010–2011), a small reptile skeleton was collected from Graphite Peak, which we present here alongside novel geological data and interpretations taken on site. Antarctanax shackletoni, gen. et sp. nov., is known from a partial postcranial skeleton including cervical and dorsal vertebrae, a humerus, and both pedes. Important morphological information includes well-defined laminae and deep fossae on cervicodorsal vertebrae. The new taxon can be differentiated from previously known Fremouw Formation reptiles (e.g., Prolacerta, Procolophon), as well as those from the Karoo Basin, South Africa (e.g., Mesosuchus, Proterosuchus, Euparkeria). Our inclusion of A. shackletoni in phylogenetic analyses of early amniotes finds it as an archosauriform archosauromorph, increasing known archosauriform diversity in the Early Triassic. The fauna of the lower Fremouw Formation traditionally has been considered to represent a subset of the Lystrosaurus Assemblage Zone of the Karoo Basin, with differences largely a result of pronounced differences in sampling intensity. However, a review of recent changes to the fauna, as well as a reassessment of occurrences based on older literature, indicates that significant discrepancies, including the co-occurrences of taxa known from both earlier and later in time and the presence of endemic forms in Antarctica, exist between the faunas of the Lystrosaurus Assemblage Zone and lower Fremouw Formation. http://zoobank.org/urn:lsid:zoobank.org:pub:B1DAD1A4-7054-454D-89B2-17CAF2865AD4 SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline. com/UJVP Citation for this article: Peecook, B. R. , R. M. H. Smith, and Christian A. Sidor. 2019. A novel archosauromorph from Antarctica and an updated review of a high-latitude vertebrate assemblage in the wake of the end-Permian mass extinction. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2018. 1536664.
Web of Science and Scopus are not global databases of knowledge

Both Web of Science and Scopus are critical components of our research ecosystem, providing the basis for university and global rankings, as well as for bibliometric research. However, both are structurally biased against research produced in non-western countries, non-English language research, and research from the arts, humanities and social sciences. This viewpoint emphasises the damage that these systematic inequities pose upon our global knowledge production systems, and the need to research funders to unite to form a more globally-representative, non-profit, community-controlled infrastructure for our global research knowledge pool.
Correlation of basal serum anti-Mullerian hormone level with oocyte quality and embryo development potential in women undergoing IVF-ICSI

Objectives: To assess and correlate the oocyte morphological characteristics and embryo development in women with normal serum anti-Mullerian hormone (AMH) levels for different age groups women undergoing in vitro fertilisation (IVF). Materials and Methods: It is a retrospective study. A total of 92 women undergoing IVF treatment with normal AMH levels within two different age groups were included in the study based on retrospectively collected data from medical records. Based on age, women were subdivided into two groups: Group A with age >23 to <30 years (n = 40) and Group B with age >30 to <38 years (n = 52). The oocyte morphological characteristics were assessed and scored based on previously published method with minor modifications. Oocytes and embryo development were correlated in both groups with different age women (>23 to <30) Group A and (>30 to <38) Group B. Results: Patients’ demographic characteristics did not show significant difference in Groups A and B, except age (P < 0.05). Number of oocyte retrieved, number of mature MII oocytes and fertilization rate have not changed in both the groups. Good quality embryo development significantly improved in Group A than that in B (P < 0.05). Even mature oocyte number in both the groups was not statistically significant. However, oocyte morphological characteristics such as (1) oocyte overall morphology, (2) zona pellucida color and thickness, (3) size of perivitelline space (PVS), (4) presence of granules and (5) morphology of polar body and pattern of cytoplasm were significantly affected in Group B older age group women when compared with younger group women (Group A). Conclusion: AMH seems to be a better predictor of quality of oocytes and subsequently embryo development in older age group women when compared to the younger group women. Normal AMH level is a better predictor for ovarian reserve and along with this, it may help to predict oocyte quality and embryo development in older women undergoing IVF. Statistical Analysis: A student t test was applied to compare the means of two groups by online GraphPad software (www.graphpad.com/quickcalcs/, GraphPad Software, La Jolla, CA, USA). A P < 0.05 was considered statistically significant. Ethics: This is a retrospective study, and informed, signed consent was obtained from every couple prior to IVF treatment. Further, permission to use their data for analysis with guarantees of confidentiality was obtained. This study was exempted of institutional review board approval, since it involved only the analysis of medical records from established clinical practices.
HBD-2 interactions with erythrocyte membranes in vitro

HBD-2 – a member of β-defensin family of antimicrobial peptides – is known to permeabilize cell membranes of susceptible cells, but the mechanism of such interactions is poorly understood. In our study, we used a hemolytic model to explore the kinetic properties of HBD-2 interactions with membranes of human erythrocytes. We ran hemolytic assays with a wide range of both HBD-2 and erythrocyte concentrations, as well as varying pH values, incubation times, and osmotic strengths; each in the presence or the absence of inhibitory substances such as proteins and salts. The results show that HBD-2 cell membrane permeabilization is both doseand time-dependent (with plateau effect observed in each case), and inversely dependent on erythrocyte concentration. HBD-2 interactions with cell membranes highly depend on pH value and the presen ce of inhibitors but are not affected by tested osmotic strength range. Our findings suggest that interactions of HBD-2 with cell membranes are mainly electrostatic in nature and are limited by released cell content. We developed a speculative model of such interaction based on our results.
Variation of thermoelectric figure-of-merits for Mg2Si x Sn1-x solid solutions

Recent advances in figure-of-merit enhancement for thermoelectric materials are mostly based on alloy material systems, which often require specific conditions to obtain the optimal electrical properties by valley convergence simultaneously with the minimized lattice thermal conductivity through maximum phonon-alloy scattering. However these conditions especially stoichiometry are often hard to control because of microstructural heterogeneity or immiscibility during material processing and prolonged use. This could easily foster the valley edge offset, inducing the negligible valley convergence as well as the abating phonon-alloy scattering. Here Mg2Si0.3Sn0. 7 pellets with different spatial uniformity were prepared by varying mixing and annealing time. Mg2SixSn1-x solid solutions of a wide alloy range were studied because the susceptible ranges for valley convergence (0.6 < x < 0.8) and phonon-alloy scattering (0.1 < x < 0.9) are dissimilar. The power factor ranged from 4.4 mWm−1 K−2 to 3.2 mWm−1 K−2 at 573 K and effective mass from 1.1 m 0 to 0.8 m 0, and thermal conductivity also varied depending on the degree of homogeneity of Mg2Si0.3Sn0. 7 due to the alteration of phonon-alloy scattering, resulting in a large swing of ZT between 1.33 and 0.8 at 673 K. Lastly we found the dependency of single valley effective mass (m* ) on valley edge offset (ΔE c) where conduction band valley X3 and X1 are broadened with valley convergence (i.e. m * at ΔE c = 0 > m * at ΔE c ≠ 0), proposing a modification on material parameter B ∼ NV (ΔE c)/m* (ΔE c), where both valley degeneracy (NV ) and m * are functions of ΔE c, on which none of any literature has paid attention so far. Our thorough investigation with an example of Mg2Si0.3Sn0. 7 can be utilized for other thermoelectric materials most of which are fundamentally relying on high valley degeneracy and alloying at the base.
Influence of Warmer and Drier Environmental Conditions on Species-Specific Stem Circumference Dynamics and Water Status of Conifers in Submontane Zone of Central Slovakia

The frequency and intensity of droughts and heatwaves in Europe with notable impact on forest growth are expected to increase due to climate change. Coniferous stands planted outside the natural habitats of species belong to the most threatened forests. In this study, we assess stem circumference response of coniferous species (Larix decidua and Abies alba) to environmental conditions during the years 2015–2019. The study was performed in Arboretum in Zvolen (ca. 300 m a.s.l., Central Slovakia) characterised by a warmer and drier climate when compared to their natural habitats (located above 900 m a.s.l.), where they originated from. Seasonal radial variation, tree water deficit (ΔW), and maximum daily shrinkage (MDS) were derived from the records obtained from band dendrometers installed on five mature trees per species. Monitored species exhibited remarkably different growth patterns under highly above normal temperatures and uneven precipitation distribution. The magnitudes of reversible circumference changes (ΔW, MDS) were species-specific and strongly correlated with environmental factors. The wavelet analysis identified species-specific vulnerability to drought indicated by pronounced diurnal stem variation periodicity in rainless periods. L. decidua exhibited more strained stem water status and higher sensitivity to environmental conditions than A. alba. Tree water deficit and maximum daily shrinkage were found appropriate characteristics to compare water status of different tree species.
A Case Study of the Westchester County New York’s Jail Response to COVID-19: Controlling COVID while Balancing Service Needs for the Incarcerated-A National Model for Jails

ABSTRACT Controlling COVID rates, which initially soared within New York State, proved to be more challenging for correctional institutions, which were tasked with trying to protect a captive population. This article profiles the Westchester County Department of Correction (WCDOC), a county jail located 20 miles north of Manhattan; it is the second-largest jail in New York State. By employing a multitude of modalities, the WCDOC was able to lower their COVID-19 rates significantly, while simultaneously providing medical, mental health, drug treatment, and court-related services. By leveraging the use of technology and employing innovative policies for prisoners and staff, the WCDOC can serve as a model for other correctional institutions.
Genetic parameters, prediction, and selection in a white Guinea yam early‐generation breeding population using pedigree information

Abstract Better understanding of the genetic control of traits in breeding populations is crucial for the selection of superior varieties and parents. This study aimed to assess genetic parameters and breeding values for six essential traits in a white Guinea yam (Dioscorea rotundata Poir.) breeding population. For this, pedigree‐based best linear unbiased prediction (P‐BLUP) was used. The results revealed significant nonadditive genetic variances and medium to high (.45–.79) broad‐sense heritability estimates for the traits studied. The pattern of associations among the genetic values of the traits suggests that selection based on a multiple‐trait selection index has potential for identifying superior breeding lines. Parental breeding values predicted using progeny performance identified 13 clones with high genetic potential for simultaneous improvement of the measured traits in the yam breeding program. Subsets of progeny were identified for intermating or further variety testing based on additive genetic and total genetic values. Selection of the top 5% progenies based on the multi‐trait index revealed positive genetic gains for fresh tuber yield (t ha−1), tuber yield (kg plant−1), and average tuber weight (kg). However, genetic gain was negative for tuber dry matter content and Yam mosaic virus resistance in comparison with standard varieties. Our results show the relevance of P‐BLUP for the selection of superior parental clones and progenies with higher breeding values for interbreeding and higher genotypic value for variety development in yam.
Association of early life factors with dyslipidemia in children and adolescents: The CASPIAN-V study

Background: This study aimed to investigate the association between prenatal/infancy factors and lipid profile in children and adolescents. Methods: This multicentric national study was conducted in 30 provinces in Iran. It comprised 4200 participants, aged 7-18 years, from the fifth survey of a national surveillance program. History regarding birth weight, as well as the type of consumed milk and food during infancy was obtained from parents. In addition to physical examinations, fasting blood samples were obtained to assess the lipid profile of these students. Results: Data from 3844 participants were available (91.5% participation rate), 52.4 % of students were boys. Mean (SD) age of participants was 12.3(3.2) years. Consuming cow milk in the first two years significantly increased the risk of high triglycerides (TG) (odds ratio [OR]:2.77, 95% CI: 1.32-5.85, P: 0.01), elevated low-density lipoprotein (LDL) (P<0.05) and low high-density lipoprotein (HDL) (P <0.05). Students who had consumed commercially made food as complementary feeding were 93% more likely to have high LDL (OR: 1.93, 95% CI=1.19-3.13, P: 0.01) and 90% more likely to have high TG than students who had consumed homemade food (OR: 1.90, 95% CI: 1.15-3.12, P: 0.01). The aforementioned figures were not significantly associated with an elevated total cholesterol (TC) level. Conclusion: Our findings revealed that the history of using human milk and home-made food as complementary feeding was associated with better lipid profile in childhood and early adolescence. Increasing public knowledge in this regard might be useful for encouragement of healthier life prevention of chronic diseases.
A Comparison of Student Engagement in Flipped, Active Lecture, and Online Counseling Courses

ABSTRACT A variety of teaching approaches have recently grown in popularity in counselor education, including flipped learning and online learning, yet no researchers have published comparisons of these course formats to traditional or active learning course formats in counselor education. In this study, we compared student course engagement in flipped, active lecture, and online course sections for same lifespan development counseling course. Flipped (n = 24) and active lecture (n = 44) participants reported statistically significantly higher engagement than online participants (n = 21). Flipped participants also reported non-significantly higher engagement than active lecture and online participants. These findings both support and contrast with previous research in other disciplines.
Brazilian Group of Gastrointestinal Tumours’ consensus guidelines for the management of gastric cancer

Gastric cancer is among the ten most common types of cancer worldwide. Most cases and deaths related to the disease occur in developing countries. Local socio-economic, epidemiologic and healthcare particularities led us to create a Brazilian guideline for the management of gastric carcinomas. The Brazilian Group of Gastrointestinal Tumors (GTG) invited 50 physicians with different backgrounds, including radiology, pathology, endoscopy, nuclear medicine, genetics, oncological surgery, radiotherapy and clinical oncology, to collaborate. This document was prepared based on an extensive review of topics related to heredity, diagnosis, staging, pathology, endoscopy, surgery, radiation, systemic therapy and follow-up, which was followed by presentation, discussion, and voting by the panel members. It provides updated evidence-based recommendations to guide clinical management of gastric carcinomas in several scenarios and clinical settings.
The Natural History of NAFLD, a Community‐Based Study at a Large Health Care Delivery System in the United States

Nonalcoholic fatty liver disease (NAFLD) is a global public health problem. However, the natural history of NAFLD is incomplete. This is a retrospective cohort study of patients identified with NAFLD by diagnosis codes in a large, community‐based health care delivery system. The objectives were (1) to follow patients from initial NAFLD presentation through progression to cirrhosis and/or decompensated cirrhosis to liver cancer, liver transplant, and death for up to 10 years; and (2) to conduct disease progression analysis restricted to patients with NAFLD identified as having diabetes at baseline. A total of 98,164 patients with full NAFLD and 26,488 with diabetes were divided into three baseline prevalent states: (1) no cirrhosis, (2) compensated cirrhosis, and (3) decompensated cirrhosis. In baseline patients without cirrhosis, annual rates of compensated cirrhosis, decompensated cirrhosis, and death were 0.28%, 0.31%, and 0.63% per year, respectively. With baseline compensated cirrhosis, the annual rates of decompensation and death were 2.4% and 6.7% per year. Finally, in those with decompensated cirrhosis at baseline, the death rate was 8.0% per year. In those without cirrhosis and with cirrhosis at baseline, the rates of liver cancer and death were increased approximately 2‐fold in the diabetic subpopulation compared with the full NAFLD cohort. Age and comorbidities increased with increasing disease severity. Cox proportional hazards regression analysis showed that cirrhosis was strongly associated with death and liver cancer, and that diabetes was associated with a significant increase in the hazard of both liver cancer and death (2.56 [2.04‐3.20] and 1.43 [1.35‐1.52]), respectively. Conclusion: The findings of this community‐based study further our understanding of the natural history of NAFLD and demonstrate that diabetes is a major factor in the progression of this disease.
The effect of in-ovo injection of Lactobacilla Rhamnosus on hatching traits and growth parameters of quails

The aim of this study was to investigate the effect of in-ovo injection of Lactobacilla Rhamnosus (0, 16x103, 32x10 and 48x103 CFU) as probiotic source on hatching parameters and growth performance of quails. In this, a total of 400 quail breeder eggs, were randomly distributed among 4 experimental groups. Each experimental group contained 4 replicates of 25 eggs each. In-ovo injections of Lactobacilla Rhamnosus into quail eggs did not statistically affect incubation characteristics and some tissue weights. A high amount of Lactobacilla Rhamnosus injection into the breeder quail eggs negatively affected live weight and live weight gain. As a result, it can be said that low or medium levels Lactobacilla Rhamnosus injection into quail eggs have no effect on incubation and growth parameters of quails.