Miracle-dz/UniFAR-FTUs huggingface dataset:
Ultrathin transmissive metasurfaces for multi-wavelength optics in the visible

Metasurface-based optical elements have the ability to shape wavefronts by locally changing the properties of incident illumination. They hold great potential to promote a new generation of wearable devices and thin optical systems for imaging and sensing. However, due to the diffractive nature of these metasurfaces, chromatic aberration represents a critical challenge toward practical implementations, especially for the visible spectrum. Existing solutions for multi-wavelength meta-optics inevitably increase the device thickness and system complexity, similar to the conventional refractive and diffractive counterparts. They are also limited to polarization sensitive lenses with a small size and numerical aperture (NA). In this manuscript, we present the design of single-layer multi-wavelength metasurfaces using ultrathin dielectric resonators (thickness ≪ wavelength) as structural elements. The electromagnetic response of these resonators can be tailored by the in-plane geometrical parameters and used to manipulate the transmitted light. We introduce a digital transmission modulation scheme which enables opportunities to design multi-wavelength optics beyond conventional binary diffractive optics. The design versatility of our approach is demonstrated by polarization-independent achromatic metalenses with a larger lens size and larger NA than existing approaches. The simplicity of the design and fabrication process makes these ultrathin metasurfaces good candidates for building flat optical elements that can be easily integrated onto CMOS electronics and MEMS devices.Metasurface-based optical elements have the ability to shape wavefronts by locally changing the properties of incident illumination. They hold great potential to promote a new generation of wearable devices and thin optical systems for imaging and sensing. However, due to the diffractive nature of these metasurfaces, chromatic aberration represents a critical challenge toward practical implementations, especially for the visible spectrum. Existing solutions for multi-wavelength meta-optics inevitably increase the device thickness and system complexity, similar to the conventional refractive and diffractive counterparts. They are also limited to polarization sensitive lenses with a small size and numerical aperture (NA). In this manuscript, we present the design of single-layer multi-wavelength metasurfaces using ultrathin dielectric resonators (thickness ≪ wavelength) as structural elements. The electromagnetic response of these resonators can be tailored by the in-plane geometrical parameters and used to.
Availability, Quality, and Evidence-Based Content of mHealth Apps for the Treatment of Nonspecific Low Back Pain in the German Language: Systematic Assessment

Background Nonspecific low back pain (NSLBP) carries significant socioeconomic relevance and leads to substantial difficulties for those who are affected by it. The effectiveness of app-based treatments has been confirmed, and clinicians are recommended to use such interventions. As 88.8% of the German population uses smartphones, apps could support therapy. The available apps in mobile app stores are poorly regulated, and their quality can vary. Overviews of the availability and quality of mobile apps for Australia, Great Britain, and Spain have been compiled, but this has not yet been done for Germany. Objective We aimed to provide an overview of the availability and content-related quality of apps for the treatment of NSLBP in the German language. Methods A systematic search for apps on iOS and Android was conducted on July 6, 2022, in the Apple App Store and Google Play Store. The inclusion and exclusion criteria were defined before the search. Apps in the German language that were available in both stores were eligible. To check for evidence, the apps found were assessed using checklists based on the German national guideline for NSLBP and the British equivalent of the National Institute for Health and Care Excellence. The quality of the apps was measured using the Mobile Application Rating Scale. To control potential inaccuracies, a second reviewer resurveyed the outcomes for 30% (3/8) of the apps and checked the inclusion and exclusion criteria for these apps. The outcomes, measured using the assessment tools, are presented in tables with descriptive statistics. Furthermore, the characteristics of the included apps were summarized. Results In total, 8 apps were included for assessment. Features provided with different frequencies were exercise tracking of prefabricated or adaptable workout programs, educational aspects, artificial intelligence–based therapy or workout programs, and motion detection. All apps met some recommendations by the German national guideline and used forms of exercises as recommended by the National Institute for Health and Care Excellence guideline. The mean value of items rated as “Yes” was 5.75 (SD 2.71) out of 16. The best-rated app received an answer of “Yes” for 11 items. The mean Mobile Application Rating Scale quality score was 3.61 (SD 0.55). The highest mean score was obtained in “Section B–Functionality” (mean 3.81, SD 0.54). Conclusions Available apps in the German language meet guideline recommendations and are mostly of acceptable or good quality. Their use as a therapy supplement could help promote the implementation of home-based exercise protocols. A new assessment tool to obtain ratings on apps for the treatment of NSLBP, combining aspects of quality and evidence-based best practices, could be useful. Trial Registration Open Science Framework Registries sq435; https://osf.io/sq435
Narcissism and Intimate Partner Violence Using Information and Communication Technology in Japan

Purpose Marital violence and violence by non-marital partners are serious problems in Japan, and an increased incidence of intimate partner violence (IPV) using information and communication technology has been observed. Narcissism is a risk factor for IPV and is correlated with aggressive behavior in ego-threatening situations. Narcissism appears in two main types, namely, grandiose and vulnerable, which differ in the expression of aggressive behavior. This study examined anxious ego threat regarding the possible failure of a dating relationship and investigated whether the two types of narcissism lead to cyber dating abuse (CDA) in this type of ego-threat situation. Method We conducted an internet questionnaire survey of 603 unmarried Japanese people (71% female, 29% male) aged 15 to 29 who had a dating partner. Results In men, when relationship anxiety was high, grandiose narcissism predicted CDA, such as direct aggression to annoy or hurt the partner and intrusive behaviors, such as persistent messaging to track the partner. Grandiose narcissism was not associated with aggressive behavior toward a dating partner in the absence of anxiety concerning the dating relationship. Vulnerable narcissism was not associated with aggressive behavior toward a dating partner, regardless of the presence or absence of anxiety concerning the dating relationship. In women, no association was found between CDA and narcissism. Conclusion In considering narcissism as a risk factor for CDA, it is insufficient to examine the relationship between narcis sism and CDA. Both types of narcissism and threat to self-evaluation must be examined.
Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma

Expression of myeloperoxidase (MPO), a key inflammatory enzyme restricted to myeloid cells, is negatively associated with the development of solid tumours. Activated myeloid cell populations are increased in multiple myeloma (MM); however, the functional consequences of myeloid‐derived MPO within the myeloma microenvironment are unknown. Here, the role of MPO in MM pathogenesis was investigated, and the capacity for pharmacological inhibition of MPO to impede MM progression was evaluated. In the 5TGM1‐KaLwRij mouse model of myeloma, the early stages of tumour development were associated with an increase in CD11b+ myeloid cell populations and an increase in Mpo expression within the bone marrow (BM). Interestingly, MM tumour cell homing was increased towards sites of elevated myeloid cell numbers and MPO activity within the BM. Mechanistically, MPO induced the expression of key MM growth factors, resulting in tumour cell proliferation and suppressed cytotoxic T‐cell activity. Notably, tumour growth studies in mice treated with a small‐molecule irreversible inhibitor of MPO (4‐ABAH) demonstrated a significant reduction in overall MM tumour burden. Taken together, our data demonstrate that MPO contributes to MM tumour growth, and that MPO‐specific inhibitors may provide a new therapeutic strategy to limit MM disease progression.
Exploring synchrony effects in performance on tasks involving cognitive inhibition: An online study of young adults

ABSTRACT Inhibition is one of the core components of cognitive control. In experimental tasks which measure cognitive inhibition, performance may vary according to an interplay of individuals’ chronotype and the time of day of testing (“synchrony effect”, or the beneficial impact on cognitive performance of aligning testing with the time of day preferred by an individual’s chronotype). Some prior studies have reported a synchrony effect specifically emerging in activities which require cognitive inhibition, but not in general processing speed, but existing findings are inconsistent. If genuine, synchrony effects should be taken into account when comparing groups of participants. Here we explored whether synchrony effects emerge in a sample of young adults. In a multi-part online study, we captured various components of inhibition (response suppression; inhibitory control; switching) plus a general measure of processing speed across various times of the day. Individuals’ chronotype was included as a predictor of performance. Critically, we found no evidence of a synchrony effect (an association between chronotype and component of interest where the directionality is dependent on time of testing) in our study.
Evaluation of retinal nerve fiber layer thickness and optic nerve head parameter in migraine as a risk factor in open angle glaucoma

Background: Migraine is a primary debilitating headache disorder with common neurolological signs. Variations in optic nerve perfusions quality or retinal may end up in ganglion cell damage in patients with migraine Methods: A prospective, analytical observational with cross sectional study was conducted at the Adam Malik Hospital from January 2016 to July Committee for Health Research Sumatera Utara University School of Medicine seven patients diagnosed with migraine divided two groups as migraine without aura and migraine with aura were evaluated. Retinal nerve fiber layer (RNFL) thickness and Optc Nerve Head (ONH) was measured by using Cirrus Optical Coherence Tomography (OCT) Results: RNFL became thinner and ONH became enlargement in several patients with migraine but not significantly differences in all quadrant between the two groups. There was significantly differences the risk of open angle glaucoma between the two groups, wheres seven migraine without aura patients and ten migraine with aura patients got nor tension glaucoma (NTG) (p<0,05). Conclusion: Normal Tension Glaucoma (NTG) is a risk factor in migraine and the retinal blood flow decreased theory might be able to defend
The Prognostic and Functional Impact of Sprouty 2 Expression in Non–small Cell Lung Cancer

Objective: We represent Sprouty 2 (Spry2) expression analysis and its association with key driver mutations and clinical features of patients with non–small cell lung cancer as the largest ex vivo data. Methods: The strength of Spry2 expression was evaluated using the immunoreactivity score (IRS), which was calculated using the following formula: IRS=(staining intensity score) SI×(percentage of positively stained cells) PP. The median IRS score was defined as the cutoff value. Patients were grouped as “weak immunoreactivity score” (IRS: 0 to 4) or “strong immunoreactivity score” (IRS: ≥4) with respect to the IRS score. Results: The intensity and percentage of Spry2 staining were significantly lower in tumor tissues than in normal lung tissues (P<0.0001). Patients’ characteristics were similar for both groups, except for smoking status and, brain and lymph node metastasis. Overall survival of patients with a strong immunoreactivity score was significantly lower than those with a weak immunoreactivity score among metastatic patients (6.9 mo vs. 13.6, P=0.023) and adenocarcinoma histology (7.0 mo vs. not reached, P=0.003). Conclusion: Spry2 expression was lower in tumor tissues than in normal lung parenchyma. Increased expression of Spry2 is associated with poor prognosis. There were no significant associations between epidermal growth factor receptor, anaplastic lymphoma kinase, or c-ros oncogene 1 rearrangement and Spry2 expression. Despite the absence of KRAS mutational analysis, the clinical and epidemiological features of patients suggested that KRAS mutation might be an underlying determinant factor of the functional role of Spry2 in non–small cell lung cancer.
Dynamic Spinal Reflex Adaptation During Locomotor Adaptation.

The dynamics and interaction of spinal and suparspinal centers during locomotor adaptation remain vaguely understood. In this work, we use Hoffmann reflex measurements to investigate changes of spinal reflex gains during split-belt locomotor adaptation. We show that spinal reflex gains are dynamically modulated during split-belt locomotor adaptation. During first exposure to split-belt transitions, modulation occurs mostly on the leg ipsilateral to the speed change, and constitutes rapid suppression or facilitation of the reflex gains, followed by slow recovery to baseline. Over repeated exposure, the modulation pattern washes out. We further show that reflex gain modulation strongly correlates with correction of leg asymmetry, and cannot be explained by speed modulation solely. We argue that reflex modulation is likely of supraspinal origins, and constitutes an integral part of the neural substrate underlying split-belt locomotor adaptation.
Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation

Airway basal stem cells (BSCs) play a critical role in epithelial regeneration. Whether coronavirus disease (COVID-19) affects BSC function is unknown. Here, we derived BSC lines from patients with COVID-19 using tracheal aspirates (TAs) to circumvent the biosafety concerns of live-cell derivation. We show that BSCs derived from the TAs of control patients are bona fide bronchial BSCs. TA BSCs from patients with COVID-19 tested negative for severe acute respiratory syndrome coronavirus 2 RNA; however, these so-termed COVID-19–exposed BSCs in vitro resemble a predominant BSC subpopulation uniquely present in patients with COVID-19, manifested by a proinflammatory gene signature and STAT3 hyperactivation. Furthermore, the sustained STAT3 hyperactivation drives goblet cell differentiation of COVID-19–exposed BSCs in an air-liquid interface. Last, these phenotypes of COVID-19–exposed BSCs can be induced in control BSCs by cytokine cocktail pretreatment. Taken together, acute inflammation in COVID-19 exerts a long-term impact on mucociliary differentiation of BSCs.
Use of remotely sensed imagery to map Sudden Oak Death (Phytophthora ramorum) in the Santa Cruz Mountains

xv Chapter One: Introduction . 1 1.1 Sudden Oak Death. 1 1.2 Role of Remote Sensing in SOD Studies . 4 1.3 Research Questions . 5 1.4 Thesis Outline. 7 Chapter Two: Related Work . 9 2.1 Biology of SOD. 9 2.2 Remote Sensing of Tree Health. 12 2.3 Mapping of SOD . 21 Chapter Three: Data and Methodology. 23 3.1 Description of Study Area . 23 3.2 Data . 25 3.2.1 Landsat Satellite Data . 26 3.2.2 National Land Cover Database Classified Raster Data . 29 3.2.3 Fire and Resource Assessment Program Vector Data . 30 3.2. 4 USDA Aerial Detection Survey Vector Data . 31 3.2. 5 Google Earth Historical Aerial Imagery. 32 3.2. 6 Land Cover Points . 32 3.2. 7 Results Validation Points. 33
A Cluster-Randomized Comparison of Music Therapy Interventions as Measured by Craving and Commitment in Adults on a Detoxification Unit

Abstract Background: Music therapy can positively impact craving, treatment readiness, and motivation in adults with substance use disorder (SUD) on a detoxification unit. However, the existing research is primarily comprised of studies with a single pre- or posttest and there is a need for randomized controlled studies that compare within-session changes resultant of various music therapy interventions to determine best practice. Objective: The purpose of this single-session study was to compare within-session changes between group motivational and educational songwriting (MESW) and group recreational music therapy (RMT) on craving and commitment to sobriety in adults with SUD on a detoxification unit. Method: Participants (N = 100) were cluster-randomized to group MESW or group RMT conditions and completed established psychometric instruments measuring craving and commitment to sobriety at pre- and posttest. Results: Within-group changes were significant in all measures, indicating that music therapy was effective within the temporal parameters of a single session. Although between-group differences were not significant, mean within-session improvements in expectancy, compulsivity, emotionality, total craving, and commitment to sobriety were larger in the MESW condition than the RMT condition. Additionally, the MESW group tended to have slightly more favorable posttest scores than the RMT group in all measures. Conclusion: Despite the temporal limitations of single-session therapy common on detoxification units, both MESW and RMT protocols resulted in significant within-session changes in measures of craving and commitment to sobriety. Implications for clinical practice, limitations of the study, and suggestions for future research are provided.
Long-term effectiveness and safety of infliximab-biosimilar: A multicenter Phoenix retrospective cohort study

Background Infliximab (IFX) effectively treats patients with inflammatory bowel disease (IBD). IFX-biosimilar (IFX-BS) has the same amino acid sequence as that of the IFX originator, and its increasing use is expected to reduce national healthcare costs. Long-term efficacy and safety of IFX-BS in patients with Crohn’s disease (CD) and ulcerative colitis (UC) have not been completely investigated. Methods We conducted a retrospective, multicenter observational study of patients with IBD who received IFX-BS treatment at three hospitals between October 2016 and April 2022. Clinical data were collected from electronic medical records and evaluated for achieving clinical remission (CR) using Crohn’s disease activity index (CDAI) and partial Mayo (pMayo) score, persistency of long-term IFX-BS administration, and clinical response rate in the bio-naïve and bio-failure groups. Results A total of 117 patients with IBD (90 CD and 27 UC) were included. The study findings indicated that both bio-naïve and bio-failure groups of patients with UC showed similar effectiveness of IFX-BS. The treatment persistence rate in patients with CD was significantly higher in the bio-naïve (P = 0.042) and switch (P = 0.010) groups than in the bio-failure group. In the former two groups, the treatment persistence rate was high at two years after administration (more than 80%). In patients with UC, the findings indicated higher treatment persistence rate in the switch group than in the bio-naïve group. Univariable and multivariable analyses for treatment persistence rate showed that the albumin level at the initial IFX-BS administration and groups (bio-naïve, bio-failure and switch) were effective factors for patients with CD. Adverse events were reported in 18 patients (15.4%). Conclusion The present study demonstrates the long-term effectiveness and safety of IFX-BS. In addition to the favorable remission induction in the bio-naïve and bio-failure groups, we demonstrated remission maintenance and treatment persistence rates beyond two years. Albumin level and groups were associated with better treatment persistence in patients with CD.
Alternative application of an iTrack microcatheter and canaloplasty: case report and literature review

ABSTRACT Introduction Glaucoma is the leading cause of irreversible blindness worldwide. Schlemm’s canal surgery using an iTrack flexible microcatheter has become popular because of its high quality-of-life issues and the growing demand for less invasive but effective procedures. The unique design of the microcatheter makes it a multimodal tool, which can be used not only in the field of antiglaucoma surgery but also as a drug delivery system to treat various conditions. Areas covered This review presents an update on the selected aspects of a drug delivery system using the iTrack microcatheter, including glaucoma gene therapy and posterior-segment diseases, both in animal models and human patients. The authors also report the case of a patient with branch retinal vein occlusion treated with suprachoroidal bevacizumab in the submacular region administered with the iTrack catheter. Expert opinion The findings presented in this study may indicate that the application of a microcatheter in open-angle glaucoma gene therapy is reasonable and can be combined with full or partial surgical canaloplasty procedures. Translation of this potential into a treatment modality would require overcoming multiple barriers.
Development and optimisation of hydroxyapatite-polyethylene glycol diacrylate hydrogel inks for 3D printing of bone tissue engineered scaffolds

In the event of excessive damage to bone tissue, the self-healing process alone is not sufficient to restore bone integrity. Three-dimensional (3D) printing, as an advanced additive manufacturing technology, can create implantable bone scaffolds with accurate geometry and internal architecture, facilitating bone regeneration. This study aims to develop and optimise hydroxyapatite-polyethylene glycol diacrylate (HA-PEGDA) hydrogel inks for extrusion 3D printing of bone tissue scaffolds. Different concentrations of HA were mixed with PEGDA, and further incorporated with pluronic F127 (PF127) as a sacrificial carrier. PF127 provided good distribution of HA nanoparticle within the scaffolds and improved the rheological requirements of HA-PEGDA inks for extrusion 3D printing without significant reduction in the HA content after its removal. Higher printing pressures and printing rates were needed to generate the same strand diameter when using a higher HA content compared to a lower HA content. Scaffolds with excellent shape fidelity up to 75-layers and high resolution (∼200 µm) with uniform strands were fabricated. Increasing the HA content enhanced the compression strength and decreased the swelling degree and degradation rate of 3D printed HA-PEGDA scaffolds. In addition, the incorporation of HA improved the adhesion and proliferation of human bone mesenchymal stem cells (hBMSCs) onto the scaffolds. 3D printed scaffolds with 2 wt% HA promoted osteogenic differentiation of hBMSCs as confirmed by the expression of alkaline phosphatase activity and calcium deposition. Altogether, the developed HA-PEGDA hydrogel ink has promising potential as a scaffold material for bone tissue regeneration, with excellent shape fidelity and the ability to promote osteogenic differentiation of hBMSCs.