Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute abdomen caused by torsion of the omentum

Abstract Rationale: Torsion of the omentum and infarction are rare and unusual disorders that often present as acute abdominal pain in the population. The diagnosis of omental torsion is based on clinical and imaging examinations. Patient concerns: A 7-year-old girl presented with acute right lower quadrant abdominal pain, with symptoms resembling acute appendicitis. Diagnosis: The patient was diagnosed with omental torsion based on imaging and laparoscopy. Interventions: Laparoscopic exploration was performed. Outcomes: The patient was discharged seven days after satisfactory postoperative recovery. Lessons: Omental torsion should be included in the differential diagnosis of acute abdominal pain, particularly in patients with free hemorrhagic fluid in the abdominal cavity and pelvis.
Search for high-mass new phenomena in the dilepton final state using proton-proton collisions at root s=13 TeV with the ATLAS detector

A search is conducted for both resonant and non-resonant high-mass new phenomena in dielectron and dimuon ﬁnal states. The search uses 3 . 2 fb − 1 of proton–proton collision data, collected at √ s = 13 TeV by the ATLAS experiment at the LHC in 2015. The dilepton invariant mass is used as the discriminating variable. No signiﬁcant deviation from the Standard Model prediction is observed; therefore limits are set on the signal model parameters of interest at 95% credibility level. Upper limits are set on the cross- section times branching ratio for resonances decaying to dileptons, and the limits are converted into lower limits on the resonance mass, ranging between 2.74 TeV and 3.36 TeV, depending on the model. Lower limits on the (cid:3)(cid:3) qq contact interaction scale are set between 16.7 TeV and 25.2 TeV, also depending on the model. © 2016 The Author. 3 .
Effects of Glibenclamide and Glimepiride Compared in Type II DM Patients in Accordance with Lipid Parameters, ESF and Glycated Haemoglobin

The population of Indian adults suffering from diabetes is expected to increase threefold, from 19.4 million in 1995 to 57.2 million in 2025. The objective of the study was to evaluate the efficacy and safety of antidiabetic drug and to find out their cardio protective action in patients with diabetes mellitus. In all, 60 patients who were newly diagnosed with Type II diabetes mellitus or who were already on treatment for Type II diabetes mellitus were enrolled in our study. The study was conducted on patients suffering from Type II diabetes mellitus for a period of 6 months from December 2011 to June 2012. These were patients attending the Medical and Surgical OPD’s of Andhra Pradesh. Estimations of Hb%, FBS, HbA 1C , Lipid Profile, ECG and Ejection Systolic Fraction (ESF) were done and compared, where HbA 1C concentration was lower in the glimepiride group. Significant reduction in the total cholesterol, serum triglyceride and LDL cholesterol was observed in the Glimepiride + Metformin combination. It also increased the HDL cholesterol levels which were not observed with Glibenclamide + Metformin for the study period of 12 weeks. Thus, the Glimepiride/Metformin combination may be considered to be a better combination in patients with increased lipid parameters in comparison with Glibenclamide/Metformin combination in patients with Type II diabetes.
Mandibular dentoalveolar reactions to rapid palatal expansion

pre- and post-expansion (post-expansion: 6 month into retention). distance made on the plaster casts for the upper and lower canines and first molars. angle of the lower first molars obtained by digitalisation of the casts and measuring on a cross-section through the first molars. RESULTS: A low but significant (p<0.001) increase of the distance between the lower first molars (1.0mm ±0.63mm SD) was found and a significant increase (p<0.001) in lower first molars angulation (3.12° ±4.67° SD) was detected. Change width was, however, not (p=0.313), and correlation
Mapping past human land use using archaeological data: a new classification for global land use synthesis and data harmonization

In the 12,000 years preceding the Industrial Revolution, human activities led to significant changes in land cover, plant and animal distributions, surface hydrology, and biochemical cycles. Earth system models suggest that this anthropogenic land cover change influenced regional and global climate. However, the representation of past land use in earth system models is currently oversimplified. As a result, there are large uncertainties in the current understanding of the past and current state of the earth system. In order to improve representation of the variety and scale of impacts that past land use had on the earth system, a global effort is underway to aggregate and synthesize archaeological and historical evidence of land use systems. Here we present a simple, hierarchical classification of land use systems designed to be used with archaeological and historical data at a global scale and a schema of codes that identify land use practices common to a range of systems, both implemented in a geospatial database. The classification scheme and database resulted from an extensive process of consultation with researchers worldwide. Our scheme is designed to deliver consistent, empirically robust data for the improvement of land use models, while simultaneously allowing for a comparative, detailed mapping of land use relevant to the needs of historical scholars. To illustrate the benefits of the classification scheme and methods for mapping historical land use, we apply it to Mesopotamia and Arabia at 6 kya (c. 4000 BCE). The scheme
Opportunity and Constraints of Cattle Production System in Three Selected Districts of Ilu Aba Bor Zone, Ethiopia

: This study was conducted in three district (Bedele, Chora and Gechi) of Ilu Aba Bor Zone, Oromia Regional State South Eastern Ethiopia. The objective of this study was to assess the opportunity and constraints of cattle production system. Multi-stage sampling techniques were employed to collect the data from a total of 216 households. Data were collected and analyzed using descriptive statistics. The study revealed that crop-livestock mixed type of farming system was the type of farming system practicing for major purposes of milk, draft and for cash sell ranked as 1 , 2 and 3 , respectively. Even though cattle were used for st nd multipurpose, the production and productivity were dominantly limited due to the feed shortage and animal disease and parasite. Mainly feed shortage was occurred due to the expansions of crop cultivation and coffee plantation as well as the dependency of most of the households on the natural grazing and browsing type of feed resources for their livestock. However, crop residues including Maize, Sorghum Stover and Teff straw were the most dominant types of low quality feed resource in the study areas. Attention of the government service without fee, presence of man power, contribution of non-governmental organizations (NGOs) and contribution of Cooperative dairy farms offered the main opportunities for better improvement of the genetics of cattle. However, uncontrolled mating system, insufficient AI technology and loss of trust on technology, feed shortage and absence of multiple/alternative veterinarian service areas were identified as the limiting factors which limit the cattle improvement program.
Exhibiting No Primary Sequence Homology the Recognition of Promiscuous Th Epitopes Degenerate Specificity at the T Cell Level in Flexibility in MHC and TCR Recognition:

2 Recognition of peptide Ags by T cells through the TCR can be highly speciﬁc. In this report we show the degeneracy of Ag recognition at both MHC and TCR levels. We present evidence that unrelated promiscuous Th cell epitopes from various protein sources exhibit sufﬁcient structural homology, despite minimal structural identity, to elicit cross-reactive proliferative responses at the bulk T cell level. This epitopic mimicry was also observed when peptide (CS.T3 378–395 and TT 830–844 )-speciﬁc CD4 1 T cell lines and T cell hybridoma clones were used in proliferation and Ag presentation assays. A scrambled CS.T3 378–395 peptide did not show any proliferation, indicating that the speciﬁcity of the cross-reactive responses may be linked with the primary structure of the peptides. Blocking of CS.T3 378–395 -speciﬁc CD4 1 T cell proliferation by anti-MHC class II mAb showed that recognition of promiscuous T cell epitopes is largely in association with MHC class II molecules. These ﬁndings suggest that promiscuous Th epitopes may be useful in designing peptide-based vaccine constructs. At the same time these results show that at the T cell level there may be a great deal of immunological cross-reactivity between heterologous pathogens, and because of this the host’s response to a pathogen may be modiﬁed by its previous experience with other unrelated pathogens. The Journal of Immunology, 2001, 166: 6693–6703.
(3)(Lambda)H and (3) ((Lambda)over-bar) (H)over-bar production in Pb-Pb collisions at root s(NN)=2.76 TeV Ante;

The production of the hypertriton nuclei 3 (cid:2) H and 3 ¯ (cid:2) H has been measured for the ﬁrst time in Pb–Pb collisions at √ s NN = 2 . 76 TeV with the ALICE experiment at LHC. The p T -integrated 3 (cid:2) H yield in one unity of rapidity, d N / d y × B . R . (cid:2) 3 (cid:2) H → 3 He , π − (cid:3) = ( 3 . 86 ± 0 . 77 ( stat. ) ± 0 . 68 ( syst. )) × 10 − 5 in the 0–10% most central collisions, is consistent with the predictions from a statistical thermal model using the same temperature as for the light hadrons. The coalescence parameter B 3 shows a dependence on the transverse momentum, similar to the B 2 of deuterons and the B 3 of 3 He nuclei. The ratio of yields S 3 = 3 (cid:2) H /( 3 He × (cid:2)/ p ) was measured to be S 3 = 0 . 60 ± 0 . 13 ( stat. ) ± 0 . 21 ( syst. ) in 0–10% centrality events; this value is compared to different theoretical models. The measured S 3 is compatible with thermal model predictions. The measured 3 (cid:2) H lifetime, τ = 181 + 54 − 39 ( stat. ) ± 33 ( syst. ) ps is in agreement within 1 σ with the world average value. beneﬁt
Hydroxychloroquine for Early Treatment of Adults With Mild Coronavirus Disease 2019: A Randomized, Controlled Trial Coronavirus type-2 (BCN

Background. No effective treatments for coronavirus disease 2019 (COVID-19) exist. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be efficacious for outpatients with COVID-19. Methods. Multicenter open-label, randomized, controlled trial conducted in Catalonia, Spain, between 17 March and 26 May 2020. Patients recently diagnosed with <5-day of symptom onset were assigned to receive HCQ (800 mg on day 1 followed by 400 mg once daily for 6 days) or usual care. Outcomes were reduction of viral load in nasopharyngeal swabs up to 7 days after treatment start, disease progression up to 28 days, and time to complete resolution of symptoms. Adverse events were assessed up to 28 days. Results. A total of 293 patients were eligible for intention-to-treat analysis: 157 in the control arm and 136 in the intervention arm. The mean age was 41.6 years (SD, 12.6), mean viral load at baseline was 7.90 log 10 copies/mL (SD, 1.82), and median time from symptom onset to randomization was 3 days. No differences were found in the mean reduction of viral load at day 3 (−1.41 vs −1.41 log 10 copies/mL in the control and intervention arm, respectively) or at day 7 (−3.37 vs −3.44). Treatment did not reduce risk of hospitalization (7.1% control vs 5.9% intervention) nor shorten the time to complete resolution of symptoms (12 days, control vs 10 days, intervention). No relevant adverse events were reported. Conclusions. In patients with mild COVID-19, no benefit was observed with HCQ beyond the usual care.
LSHTM Research Online in following

Background: The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such as cytokines and chemokines. Gene expression regulation following microbial recognition is partly regulated by chromatin re-organization and has been described in immune cells but data from epithelial cells is not as detailed. Here, we report genome-wide changes of the H3K27ac mark, characteristic of activated enhancers and promoters, after stimulation of nasopharyngeal epithelial cells with the bacterial endotoxin Lipopolysaccharide (LPS). Results: In this study, we have identified 626 regions where the H3K27ac mark showed reproducible increase following LPS induction in epithelial cells. This indicated that sensing of LPS led to opening of the chromatin in our system. Moreover, this phenomenon seemed to happen extensively at enhancers regions and we could observe instances of Super-enhancer formation. As expected, LPS-increased H3K27ac regions were found in the vicinity of genes relevant for LPS response and these changes correlated with up-regulation of their expression. In addition, we found the induction of H3K27ac mark to overlap with the binding of one of the NF-kB members and key regulator of the innate immune response, RELA, following LPS sensing. Indeed, inhibiting the NF-kB pathway abolished the deposition of H3K27ac at the TNF locus, a target of RELA, suggesting that these two phenomena are associated. Conclusions: Enhancers ’ selection and activation following microbial or inflammatory stimuli has been described previously and shown to be mediated via the NF-kB pathway. Here, we demonstrate that this is also likely to occur in the case of LPS-sensing by nasopharyngeal epithelial cells as well. In addition to validating previous findings, we generated a valuable data set relevant to the host immune response to epithelial cell colonizing or infecting pathogens.
Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Pro ﬁ les

Rationale: Two biologic phenotypes of acute respiratory distress syndrome (ARDS) have been identi ﬁ ed based on plasma protein markers in four previous studies. Objectives: To determine if blood leukocyte gene expression is different between the “ reactive ” and “ unin ﬂ amed ” phenotype. Methods: This is a new study adding blood leukocyte transcriptomics and bioinformatics analysis to an existing patient cohort of ARDS in patients with sepsis admitted to two ICUs during a 1.5-year period. Canonical pathway analysis was performed. Measurements and Main Results: A total of 210 patients with sepsis and ARDS were included, of whom 128 had a reactive and 82 an unin ﬂ amed phenotype. A total of 3,332/11,443 (29%) transcripts were signi ﬁ cantly different between the phenotypes. Canonical pathway analysis showed upregulation of oxidative phosphorylation genes indicative of mitochondrial dysfunction (52% of genes in pathway). The unin ﬂ amed phenotype was characterized by upregulation of mitogen-activated protein kinase pathways. Conclusions: A third of genes are differentially expressed between biologic phenotypes of ARDS supporting the observation that the subgroups of ARDS are incomparable in terms of pathophysiology. These data provide additional support for biologic heterogeneity in patients with ARDS and suggests that a personalized approach to intervention focusing on oxidative phosphorylation is pivotal in this condition.
KNOWLEDGE, ATTITUDE AND PRACTICE ABOUT DENGUE FEVER AMONG PATIENTS IN PAKISTAN

: Dengue Fever (DF) is an acute febrile illness caused by a mosquito borne human virus belonging to Flaviviridae family. Four types of serotypes have been found (DENV 1, DENV 2, DENV 3 and DENV 4). The virus is transmitted by the Aedes mosquito, in which Aedes aegypti is the major vector . Iinfection with dengue virus may be asymptomatic, it may lead to a wide spectrum disease that ranges from non-severe fever to potentially fatal clinical manifestations. According to the World Health Organization (WHO), among arboviral infection diseases, dengue is considered to be one of the most common types in the world; with approximately 390 million infected cases yearly, and 40% of the world population living in at-risk areas. In many parts of the tropics and subtropics, dengue is endemic especially during rainfall season which is the breeding season of the Aedes mosquito. Incidence dramatically increased to 2 million cases from 2008 to 2015 among the American, South-East Asian and Western Pacific regions, and extended to some European countries due to globalization and traveling. Symptoms similar to the flu, dengue fever (DF) can progress to severe and life-threatening stages which involves severe bleeding, respiratory and organ impairment.
PGPM_A_278897 591..599

1Department of Endocrinology, ChinaJapan Friendship Hospital, Beijing 100029, People’s Republic of China; 2Department of Endocrinology, Emergency General Hospital, Beijing 100028, People’s Republic of China; 3Department of Statistical Teaching and Research, ChinaJapan Friendship Hospital, Beijing 100029, People’s Republic of China Background: The cannabinoid receptor 1 (CNR1) gene polymorphism is reportedly associated with components of metabolic syndrome and coronary artery diseases in patients with type 2 diabetes mellitus (T2DM). We investigated whether the common variant rs10493353 polymorphism is associated with diabetic nephropathy (DN) in T2DM patients. Patients and Methods: T2DM patients with DN were enrolled as a case group, and patients with only T2DM as a control group. Demographic data and biochemical parameters were collected. The polymerase chain reaction-based restriction fragment length polymorphism technique was used for genotyping. The odds ratio and 90% confidence interval were calculated to assess the association between genotypes and the risk of DN. Results: In total, 320 T2DM patients and 320 DN patients were enrolled. Compared with T2DM patients, the DN patients have a significantly larger body mass index (BMI), longer duration of disease, and higher proportions of smokers, drinkers, and hypertension. The risk of DN was significantly decreased by genotypes AA (OR=0.39, 95% CI=0.23–0.67) and GA (OR=0.53, 95% CI=0.37–0.75) vs GG (codominant model), GA/AA vs GG (OR=0.49, 95% CI=0.35–0.67; dominant model), AA vs GG/GA (OR=0.47, 95% CI=0.28–0.80; recessive model), and the A allele (OR=0.52, 95% CI=0.40–0.68; allele model). Multiple logistic regressions still show significant levels. Negative interactions were found between gene and clinical parameters, including drinking, smoking, BMI, and hypertension. Conclusion: The A allele of CNR1 gene rs10493353 may be a protective factor for DN in T2DM patients. The risk factors of DN can affect the protective role of A allele in the progression of DN.
Prevalence of Haemonchus contortus of Sheep Slaughtered at

: Haemonchus contortus is a blood sucking nematode parasite of sheep all over the tropics and subtropics which causes retarded growth, lower productivity and even mortality in young animals. A cross sectional study was conducted from November, 2016 to March, 2017 in sheep to determine the prevalence of H. contortus in randomly selected sheep slaughtered at Bahir Dar municipal abattoir in Bahir Dar city. In the present study, a total of384 sheep (200 males and 184 females) were slaughtered at the municipal abattoir and inspected for the presence or absence of the parasite. Accordingly, the findings of this study revealed that an overall infection rate of 56.25% was recorded. Among the male and female slaughtered sheep, 92 (46%) and 124 (67.4%) were found to be positive for H. contortus, respectively; and shows a statistical significant difference (P < 0.05) between sex. Based on age group, prevalence of haemonchosis was 123 (65.1%) and 93 (47.7%), in young and adult, respectively. The result from the present study indicated that there was statistical significance (P < 0.05) among age groups. Furthermore, a statistically significance difference (P < 0.05) was observed within Origin, body condition and month of inspection. However, there was no statistically significance difference (P > 0.05) among the breed of sheep. In the present study, high infection rate of H. contortus was observed in sheep during the study period. Therefore, strategic prevention and control measures should be implemented to decrease the burden of the parasitic infection so as to enhance productivity.
A Sensor-based System for Detecting and Registering Dump Truck Flatbed Tilts

Improving the productivity in construction sites is an ongoing priority within the construction industry due to the benefits that comes with increased efficiency in construction projects where sensor technology has become a more common tool used for the pursuit of increased productivity. This project set out to implement a sensor-based system that is used on a construction site to register when a dump truck tilts its flatbed, acting as a confirmation of delivery. The work was done for a Swedish company active in the construction industry. Since construction sites provide a rough environment to operate in, a requirements specification was developed from interviews and observations done on the construction site. From the requirement specification, two prototypes were developed for testing, one with an ultrasonic sensor and one with an accelerometer. The prototypes both used an Arduino board as a controller, the Bluetooth protocol for communication between the controller and the gateway. An Android smartphone was used as the gateway. These prototypes were then tested in two phases, first in office and later mounted on a truck on the construction site. While the results from the test on the construction site were inconclusive, the results from the first test phase showed a slight advantage to the prototype implemented with the accelerometer.
An e⁄cient gene transfer system for the pimaricin producer Streptomycesnatalensis

Streptomyces natalensis produces the antifungal polyene macrolide pimaricin. Genetic manipulation of its biosynthetic genes has been hampered by the lack of efﬁcient gene transfer systems. We have developed a gene transfer system based on intergeneric conjugation from Escherichia coli . Using this approach, we managed to attain transformation efﬁciencies of 1 (cid:1) 10 (cid:2) 4 exconjugants per recipient when using self-replicating vectors such as pHZ1358. The use of integrative vectors such as pSET152 or pSOK804 resulted in signiﬁcantly lower efﬁciencies. Site-speciﬁc integration or the use of self-replicating plasmids did not affect pimaricin production or the essential functions of S. natalensis . Use of DNA methylation proﬁcient E. coli donor strains resulted in no transformants, indicating the presence of methyl-speciﬁc restriction systems in S. natalensis . This methodology will enable easier manipulation of the genes responsible for pimaricin biosynthesis, and could prove valuable for the generation of new designer polyene macrolides with better antifungal activity and pharmacological properties. As an example of the validity of the method, we describe the introduction of Supercos-1-derived cosmid vectors into S. natalensis in order to promote gene replacements by double crossover recombination. was observed in exconjugants when compared with the control strain (not no production was observed. More studies will be necessary to get a deeper insight into the effect of the different and in other of
Difficult Surgical Aspect of a Compressive Hemangioma of the Cavernous Sinus in a Neurosurgical Setting in Senegal: About a Case and Review of the Literature

Cavernous sinuses Hemangiomas (CSH) are rare benign extra-axial tumours, mainly affecting middle-aged women. Symptoms vary, but are usually due to a mass effect and include headaches, changes in vision and paralysis of the cranial nerves [1]. They account for 13% of all intracranial cavernous Hemangiomas, 3% of all benign tumours presentation, imaging results and difficult surgical management of a patient with cavernous sinusHemangioma enveloping the cavernous segment of the carotid artery, which made surgical resection difficult.