Miracle-dz/UniFAR-FTUs huggingface dataset:
Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells

Our study explored the tumor-suppressive effect of curcumin on cervical cancer cells. Cervical cancer is one of the most common cancers among women worldwide. Acquired resistance to chemotherapeutics and toxicity of such drugs has undermined the effectiveness of cervical cancer treatments. Therefore, the identification of novel chemotherapeutics is key to improving the survival of patients with cervical cancer. Curcumin has been shown to have various bioactivities, including antioxidant and antitumor effects; however, its effect on cervical cancer remains elusive. Here, we used the SiHa human cervical cancer cell line to test various concentrations of curcumin on the proliferation and apoptosis of cervical cancer cells. The involvement of autophagy and reactive oxygen species (ROS) in these effects were also tested by using specific autophagy inhibitors and ROS scavengers. Our results showed that curcumin induced ROS accumulation, apoptosis, autophagy, cell cycle arrest, and cellular senescence accompanied by upregulation of p53 and p21 proteins in SiHa cells.
The Impact of Sleeve Gastrectomy on Females With Polycystic Ovarian Syndrome From 2018 to 2020 in Riyadh, Saudi Arabia: A Prospective Study

Background: Obesity is one of the most common risk factors for polycystic ovarian syndrome (PCOS). Reducing body weight has shown to improve the symptoms of PCOS; however, it is still unclear if the surgical treatment of obesity can have better outcomes to control obesity and improve PCOS. Objective: This study aims to identify the impact of sleeve gastrectomy on PCOS symptoms in Riyadh, Saudi Arabia with a comparison of other weight reduction surgeries. Design and Setting: This is a prospective study that included patients with PCOS who had weight reduction surgeries between 2018 and 2020, in Riyadh, Saudi Arabia. Using an online questionnaire, demographic data will be collected and information about menstruation, abortion, polycystic ovarian syndrome, and bariatric surgeries (if any). Data analysis was done through Statistical Package for the Social Sciences (SPSS) v26 (IBM Corp., Armonk, NY, USA). Results: Ninety-nine female patients responded to this survey, all of whom had PCOS; 57.6% of these patients had a positive family history of PCOS. The most-reported PCOS symptoms were irregular menses (63.6%) and weight gain (53.5%), while 9.1% were asymptomatic. 52.5% were obese, and 91.1% underwent gastric sleeve surgery to treat their obesity. 41.4% of the females had a regular cycle before the operation, which increased to 60.6% after the operation; 48.5% had a normal flow before the operation, which increased to 61.6% after the operation. 15.2% conceived once before the operation, which increased to 16.2% after the operation. 11.1% had one abortion before surgery, which decreased to 7.1% after surgery. 55.6% observed an improvement in their PCOS symptoms after surgery, and 47.5% found that their fertility improved according to their own perception. Females with a positive family history of PCOS had a higher prevalence of PCOS (p-value <0.001). Also, females 30-39 years old are significantly more likely to have PCOS (p-value <0.001). The incidence of abnormal menstrual flow and irregular menstrual cycle was seen significantly more in PCOS patients than non-PCOS (p-value=0.019 and 0.004, respectively). PCOS symptoms and fertility significantly improved after surgery (p-value=0.031 and 0.043, respectively). Conclusion: Sleeve gastrectomy can lead to significant improvement in fertility and symptoms of PCOS. It can also reduce the incidence of abortion. Other surgical techniques should be investigated.
Gravity field of the Saturnian system from Pioneer and Voyager tracking data

Data sets from the Voyager and Pioneer flybys of Jupiter and the Galilean satellites are employed to characterize the Jovian magnetic field and the effects of the Io torus on transmissions. Both optical and Doppler radio data are considered, except for periods when the Jovian radiation environment disturbed the oscillator stability of the radio transmitters. Account is taken of small accelerations of the spacecraft by tidal forces of a single rising satellite, density differences in the Great Red Spot producing a columnar gravitational change, and three unknown objects in the inner Jovian system. Correction parameters are developed for the effects on the S-band data induced by the Jovian plasmasphere inwards from the Io torus. Calculations are then made of the planet and satellite masses, gravity harmonic coefficients, and orientation of the rotational pole. Large reductions in the uncertainties in previous mass estimates are obtained.
Intrinsic bioremediability of petroleum hydrocarbon contaminated sites in Romania: Diveristy of bacterial community, catechol dioxygenase and alkane-monooxygenase

Bacteriile endogene hidrocarbonoclastice joacă un rol important in procesul autoepurării solurilor contaminate cu diferite hidrocarburi. Prin intermediul sistemelor enzimatice microorganismele catalizează mineralizarea contaminanţilor in forme netoxice, cum ar fi CO2 si H2O. Pentru evaluarea bioremedierii intrinseci este esenţială cunoasterea structurii comunităţilor microbiene, precum si numărul si activitatea organismelor descompunătoare. Prin detectarea genelor funcţionale (C23O, C12O si alkB) folosind primeri oligonucleotidici specifici, avem posibilitatea de a determina populaţia bacteriană care este activă in biodegradarea contaminanţilor. Metode convenţionale de microbiologie si de biologie moleculară au fost folosite pentru realizarea lucrării. Indigenous hydrocarbon-degrading bacteria play an important role in natural attenuation process of hydrocarbon contaminated soils. Through enzyme systems they catalyze the mineralization of contaminants into non toxic forms, into CO2 and H2O. In order to assess the intrinsic bioremediability is essential to know the microbial community structure, as well as the number and activity of degrading organisms. By detection of functional genes (C23O, C12O and alkB) using speciesspecific oligonucleotide primers we had the opportunity to elucidate the bacterial population that was actually active in biodegradation of contaminants. To achieve these goals conventional microbiological and molecular-biological methods were carried out.
FIELD INVESTIGATION ON IMPORTANT INSECT-PESTS OF MANGO AND THEIR MANAGEMENT

“FIELD INVESTIGATION ON IMPORTANT INSECT-PESTS OF MANGO AND THEIR MANAGEMENT” Name of the Student Major Advisor Mr. PATEL K.B. Dr. S.P.SAXENA DEPARTMENT OF AGRICULTURAL ENTOMOLOGY N.M. COLLEGE OF AGRICULTURE NAVSARI AGRICULTURAL UNIVERSITY NAVSARI396 450
The Impact of Dental Treatments on Blood Pressure Variations

Objectives: The aim was to determine whether there are alterations in the fluctuations of systolic and diastolic blood pressure or the heart rate of normotensive versus hypertensive participants undergoing antihypertensive treatment during surgical and non-surgical dental treatments, regarding whether or not anaesthetics were used with a vasoconstrictor. Materials and methods: A prospective, observational, epidemiological study was conducted in a sample of 200 participants older than 65 years (100 normotensive and 100 hypertensive participants on antihypertensive treatment). Five periods for evaluation were established. Demographic information was obtained regarding whether or not anaesthetics were used (with or without a vasoconstrictor) and whether or not the participants underwent surgical treatment. The statistical analysis consisted of a doubly multivariate analysis of repeated measures for multiple dependent variables. Results: Significant differences were observed in the evolution of systolic blood pressure, with an initial increase in participants undergoing surgical treatment and those without a vasoconstrictor. On the other hand, systolic blood pressure decreased with non-surgical treatments, but it remained stable with the use of a vasoconstrictor. Diastolic blood pressure showed no interaction effect in participants undergoing surgical or non-surgical treatments; with the use of a vasoconstrictor, it initially decreased, while in the absence of a vasoconstrictor, it increased. Heart rate initially decreased in participants undergoing surgical and non-surgical treatments and was analogous whether or not a vasoconstrictor was used. Conclusions: During blood pressure monitoring, blood pressure variations occur, but there is no clinical repercussion in participants because once the treatment is completed, the initial values are recovered. Arterial hypertension is a pathology of high prevalence that tends to increase with age. The blood pressure response to surgical and non-surgical dental treatments and the effect of local anaesthetics is important because follow-up and blood pressure control in older patient cohorts can improve dental and clinical management.
Classification and Phylogenetic Significance of Molluscan Shell Microstructure

Like most classifications of molluscan shell microstructure published during the past 25 years (e.g., MacClintock, 1967; Kobayashi, 1964, 1971; Taylor, Kennedy and Hall, 1969, 1973; Gregoire, 1972a), the present one is based largely on Boggild's (1930) monographic work, redefined from a modern perspective of combined light and scanning electron microscopy. However, this is the first attempt to integrate shell microstructure terminology for mollusks with that employed by students of bryozoan and brachiopod shell microstructure (e.g., Williams, 1968a,b, 1970, 1973; Williams and Wright, 1970; Armstrong 1968, 1969; Sandberg, 1971, 1977; Brunton, 1972; MacKinnon, 1974, 1977; MacKinnon and Williams, 1974; Iwata, 1981, 1982). An integration of nomenclatorial schemes is desirable for purposes of interphylum comparison, and is presently needed because there is considerable overlap and inconsistency in the application of microstructural terminology even within single molluscan classes. The present synthesis of shell microstructure nomenclature is possible primarily because of the extensive data base of invertebrate shell mineralogy, microstructure and especially ultrastructure published in more than 300 references in the past 15 years. To these data, the authors have contributed original information of shell mineralogy and microstructure for scores of Recent and fossil mollusks, brachiopods and bryozoans, with a clear emphasis on bivalved mollusks. Many inadequately described microstructure terms have been reanalyzed during the course of this study, either by examining species cited in the literature, or by using closely related species. Perhaps because they are better studied, but probably for other reasons as well, the diversity of molluscan shell microstructures is considerably greater than that of brachiopods and bryozoans combined (Carter, 1979). Consequently, most of the present nomenclature is based on mollusks, and only three of the major microstructural arrangements described in this guide (crossed bladed, semi-nacreous and semi-foliated) were known first in brachiopods or bryozoans and later recognized in molluscs.
Anti-müllerian hormone and ovarian function

Anti-mullerian hormone(AMH) is a member of the transforming growth factor-β superfamily.It is named because it induces muller's duct degeneration in the males.In females,AMH is produced only by granulose cells in preantral and small antral follicles of ovary.Serum AMH level is associated closely with ovarian function,so it is a new marker to evaluate ovarian aging and to predict the ovary responsiveness to ovalution stimulants.In addition,it is related to development and clinical characteristics of polycystic ovarian syndrome.
Principal Components and Clustering Analysis for Major Quantitative Traits of Adzuki Bean

The correlation characteristics,principal component analysis and cluster analysis of 10 major quantitative traits of 13 adzuki beans varieties were analyzed.The results showed the variant coefficient of 10 major quantitative traits was 33.56%～2.37%,the biggest variant coefficient was branches number per plant and the least value was growth period.The results of correlation analysis showed significantly positive relationship between branches number per plant and yield per plant.The results of principal component analysis showed that the cumulative contribution ratio of the four principal components,including factors of pod type,seeds number per pod,growth period and yield,to the total variation reached 86.48%. The 13 adzuki bean varieties were classified into 4 groups using cluster analysis,and there was a significant difference between the various group for yield per plant,and there were difference between predominant factors,so it should comprehensively consider the quantitative traits according to the breeding purposes.It should take the branches number per plant as key trait for selecting mutants of high yield during adzuki bean mutation breeding,and then only by taking different characters comprehensively into consideration,could we successfully select the mutants with fine characters.
Growth and Development Characteristics and Yield Formation of Dry-cultivated Rice

With the indica hybrid combination of Shanyou 63 and japonica cultivar of Zhendao 88 as materials, the characteristics of growth and development and yield formation of dry cultivated rice (plastic film mulching cultivation) were studied. Compared to moist cultivated rice (conventional cultivation), dry cultivated rice had slower tillering, smaller leaf area index and less accumulation of dry matter before the critical stage of productive tillers, and the results were reversed at the jointing. The length of each elongated internode, percentage of productive tillers, grain leaf ratio [spikelets/leaf area (cm 2)], photosynthetic rate at mid and late grain filling stages, dry weight at maturity, and active grain filling period of dry cultivated rice were smaller or lower than those of moist cultivated rice, but the former was larger or higher than the later, in terms of the root dry weight at heading, root shoot ratio, root activities at the early grain filling stage, grain filling rate, transfer ratio of total assimilates and harvest index. Dry cultivated rice had fewer spikelets per panicle but more panicles per unit area than moist cultivated rice. There was no significant difference between the two cultivated methods in the percentage of ripened grains. The differences in grain weight and yield between dry and moist cultivated rice were significant for Zhendao 88 but not significant for Shanyou 63. The approaches to increasing the grain yield in dry cultivated rice were discussed.
All alloparents are not equally valuable: Primary breeders and group size explain group reproductive success in cooperatively breeding primates

The effect of a cooperatively breeding group′s composition on its reproductive output (GRO) has been difficult to assess across populations and species. Prior research has correlated GRO with age and sex classes, not accounting for uneven sample sizes and pseudoreplication at the group or species level. This study utilizes a multistep modelling approach to assess whether breeding status explains GRO better than age-sex classes among free-ranging saddleback ( Saguinus weddelli ) and emperor tamarins ( S. imperator ) in Peru. Dimension reduction analyses were performed on 6 years of morphometric data to assign breeding status to individuals. Three analytical approaches (GLMM, binomial logistic regression and multinomial logistic regression) were used to model the effects of breeding status on GRO in the current dataset and a historical dataset derived from previous studies of wild callitrichids. Though alloparents have long been considered critical to reproductive success in cooperative breeders, these results indicate that group size and the proportion of primary breeders are the most significant factors contributing to GRO. This indicates that reproductive suppression of subordinate females may even be detrimental to GRO and though additional primary breeding males increased GRO, the addition of secondary breeders, male or female, did not.
Trace-element geochemistry of ore-associated and barren, felsic metavolcanic rocks in the Superior Province, Canada

Archaean felsic metavolcanic rocks in the Superior Province of the Canadian Shield may be divided into three major groups on the basis of trace-element abundances and ratios. (1) FI felsic metavolcanic rocks are dacites and rhyodacites characterized by steep REE patterns with weakly negative to moderately positive Eu anomalies, high Zr/Y, low abundances of high-field-strength elements (e.g., HREE, Y, Zr, Hf), and high abundances of Sr. Examples occur in the Bowman Subgroup and Skead Group in the Abitibi Belt, in the Kakagi Lake, Lake of the Woods, Shoal Lake, and Sturgeon Lake areas of the Wabigoon Belt, and in the Confederation Lake area of the Uchi Belt. None of these horizons, as known, hosts base-metal sulphide deposits. (2) FII felsic metavolcanic rocks are rhyodacites and rhyolites characterized by gently sloping REE patterns with variable Eu anomalies, moderate Zr/Y, and intermediate abundances of HFS elements and Sr. Examples occur in the Misema Subgroup of the Abitibi Belt, in the Wabigoon Lake a.
Identification of images of COVID-19 from Chest Computed Tomography (CT) images using Deep learning: Comparing COGNEX VisionPro Deep Learning 1.0 Software with Open Source Convolutional Neural Networks

For testing patients infected with COVID-19, along with RT-PCR testing, chest radiology images are being used. For the detection of COVID-19 from radiology images, many organizations are proposing the use of Deep Learning. University of Waterloo and DarwinAI, have designed their own Deep Learning model COVIDNet-CT to detect COVID-19 from infected chest CT images. Additionally, they have introduced a CT image dataset COVIDx-CT, from CT images collected by the China National Center for Bioinformation. COVIDx-CT contains 104,009 CT image slices across 1,489 patient cases. After obtaining remarkable results on the identification of COVID-19 from chest X-ray images by using the COGNEX VisionPro Deep Learning Software 1.0 this time we test the performance of the software on the identification of COVID-19 from CT images. COGNEX Deep Learning Software: VisionPro Deep Learning, is a Deep Learning software that is used across various domains ranging from factory automation to life sciences. In this study, we train the classification model on 82,818 chest CT training and validation images from the COVIDx-CT dataset in 3 classes - normal, pneumonia, and COVID-19 and then test the results of the classification on the 21,191 test images are compared with the results of COVIDNet-CT and various other state of the art Deep Learning models from the open-source community. Also, we test how reducing the number of images in the training set effects the results of the software. Overall, VisionPro Deep Learning gives the best results with F-scores over 99%, even as the number of images in the training set is reduced significantly. This software is by no means a stand-alone solution in the detection of COVID-19 but can aid radiologists and clinicians in achieving faster and understandable diagnosis using the full potential of Deep Learning, without the prerequisite of having to code in any programming language.
Flexible Memory Processing by Rats: Use of Prospective and Retrospective Information in the Radial Maze

Four experiments investigated the content of the memory used by rats in mediating retention intervals interpolated during performance in a 12-arm radial maze. The delay occurred following either the 2nd, 4th, 6th, 8th, or 10th choice. A 15-min delay had the greatest disruptive effect when interpolated in the middle of the choice sequence and less of an effect when it occurred either earlier or later. This pattern of results was obtained when either a free- or forced-choice procedure was used prior to the delay and regardless of whether postdelay testing consisted of completion of the maze or two-alternative forced-choice tests. Assuming that the disruptive effect of a delay is a function of memory load, this implies that the rats used information about previously visited arms (retrospective memory) following an earlier interpolated delay but information about anticipated choices (prospective memory) following a delay interpolated late in the choice sequence. There appeared to be a recency effect only in the early and middle delay conditions. This provides converging evidence for the dual-code hypothesis. No evidence for prospective memory was obtained following a 60-min delay.
Field Studies of Cereal Leaf Growth

Measurements of leaf initiation, appearance, and expansion are presented for winter wheat and spring barley crops. For winter wheat, these processes occurred during periods of several weeks when fluctuating temperatures influenced process rates. Analysis of these measurements was facilitated by plotting variables against the time integral of temperature above an appropriate base temperature (0 °C), here called thermal time with units of °C d. Leaf primordial number and appearance stage increased linearly with thermal time for both winter wheat and spring barley which initiated 12 and 9 leaves respectively. When plotted against thermal time 90% of laminar and leaf length growth and 80% of laminar width growth was satisfactorily described by a straight line for both species. This enabled an average extension rate and duration of linear growth to be defined for each leaf. When expressed in thermal time, wheat leaves had a similar duration of linear growth (210 °C d; s.d. 30 °C d) with insolation exerting a negligible influence. The first seven barley leaves had a shorter duration of linear growth (151 °C d; s.d. 8 °C d). For wheat, final leaf length and laminar width increased with leaf number and were not apparently associated with changes in apical development stage. Changes of barley leaf dimensions with leaf number were more complex.
Sugar Transport Inhibition and Apparent Loss of Activity inSaccharomyces cerevisiaeas a Major Limiting Factor of Enological Fermentations

Under enological conditions, yeast growth arrest occurs when the medium still contains high sugar concentrations. Even before this stage of fermentation, it appears as a rapid inhibition of fermentative metabolism. By taking into account the cumulative effects of the apparent loss of activity of the sugar transport system, the non-competitive inhibitory effect of ethanol on the glucose transport system, and the variation of sugar concentration along fermentation, we were able to correct experimental data of sugar transport rate in order to obtain in situ uptake activities and thus, theoretical instantaneous rate of CO2 production. This theoretical rate appears to be in close correlation with the experimental CO2 production rate, when the decay of sugar transport activity has begun, showing that sugar transport is the main limiting factor of fermentation under these conditions.