Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring thermal effects of the hadron-quark matter transition in neutron star mergers

We study the importance of the thermal behavior of the hadron-quark phase transition in neutron star (NS) mergers. To this end, we devise a new scheme approximating thermal effects to supplement any cold, barotropic hybrid equation of state (EoS) model, i.e. two-phase EoS constructions with a hadronic regime and a phase of deconfined quark matter. The consideration of temperature-dependent phase boundaries turns out to be critical for a quantitative description of quark matter effects in NS mergers, since the coexistence phase can introduce a strong softening of the EoS at finite temperature, which is even more significant than the change of the EoS by the phase transition at T=0. We validate our approach by comparing to existing fully temperature-dependent EoS models and find a very good quantitative agreement of postmerger gravitational-wave (GW) features. Simulations with the commonly-used thermal ideal-gas approach exhibit sizable differences compared to full hybrid models implying that its use in NS merger simulations with quark matter is problematic. Our new scheme provides the means to isolate thermal effects of quark matter from the properties of the cold hybrid EoS and thus allows an assessment of the thermal behavior alone. We show that different shapes of the phase boundaries at finite temperature can have a large impact on the postmerger dynamics and GW signal for the same cold hybrid model. This finding demonstrates that postmerger GW emission contains important complementary information compared to properties extracted from cold stars. We also show by concrete examples that it is even possible for quark matter to only occur and thus be detectable in finite-temperature systems like merger remnants but not in cold NSs (abbreviated).
Learning with augmented target information: An alternative theory of Feedback Alignment

While error backpropagation (BP) has dominated the training of nearly all modern neural networks for a long time, it suffers from several biological plausibility issues such as the symmetric weight requirement and synchronous updates. Feedback Alignment (FA) was proposed as an alternative to BP to address those dilemmas and has been demonstrated to be effective on various tasks and network architectures. Despite its simplicity and effectiveness, a satisfying explanation of how FA works across different architectures is still lacking. Here we propose a novel, architecture-agnostic theory of how FA works through the lens of information theory: Instead of approximating gradients calculated by BP with the same parameter, FA learns effective representations by embedding target information into neural networks to be trained. We show this through the analysis of FA dynamics in idealized settings and then via a series of experiments. Based on the implications of this theory, we designed three variants of FA and show their comparable performance on several tasks. These variants also account for some phenomena and theories in neuroscience such as predictive coding and representational drift.
Magnetic properties of various martensitic phases in Ni-Mn-Ga alloy

Single crystalline Ni/sub 48.7/Mn/sub 29.1/Ga/sub 22.2/ sample was studied in the temperature range 110 K-425 K. Magnetic properties of four different structure phases were measured at different temperatures. The magnetic anisotropies of the different phases were determined from magnetization curves. At room temperature, the structure is five-layered modulated tetragonal martensite with c/a 1. A single variant of low-temperature martensite was obtained by cooling in magnetic field 1.4 T. At 173 K, the sum of magnetic anisotropy constants is K/sub 1/+K/sub 2/=1.5/spl times/10/sup 5/ J.m/sup -3/ assuming an easy-plane magnetic anisotropy.
Effect of optical injection on bias voltage and spectrum of a semiconductor laser

The effect of a mild form of optical injection on the bias voltage and optical spectrum of a Fabry-Perot-type AlGaAs laser has been studied. At small frequency detuning between the injection and the injected laser, injection locking is observed. The change in bias voltage, as a function of detuning, is dispersive-like and asymmetric, From the asymmetry, the alpha -parameter of the laser is determined. When the detuning is increased beyond the locking range, the effect of optical injection on bias voltage remains noticeable. Additional dispersive-like structures appear around the relaxation oscillation frequency. In the optical spectrum, four-wave mixing and reduced damping of the relaxation oscillations are observed. >
MULTIVARIATE EXTREMAL PROCESSES, LEADER PROCESSES AND DYNAMIC CHOICE MODELS

Let (Y(t), t>O0) be a d-dimensional non-homogeneous multivariate extremal process. We suppose the ith component of Y describes time-dependent behaviour of random utilities associated with the ith choice. At time t we choose the ith alternative if the ith component of Y(t) is the largest of all the components. Let J(t) be the index of the largest component at time t so J has range {1, ? , d} and call {J(t)) the leader process. Let Z(t) be the value of the largest component at time t. Then the bivariate process (J(t), Z(t)} is Markov. We discuss when J(t) and Z(t) are independent, when (J(s), O<s_5 t} and Z(t) are independent and when J(t) and {Z(s), O<s_ t} are independent. In usual circumstances, {J(t)} is Markov and particular properties are given when the underlying distribution is max-stable. In the max-stable time-homogeneous case, {J(et)} is a stationary Markov chain with
Low Frequency Oscillations in the Diverging Cusped-Field Thruster

thruster is markedly bi-modal, with a sharp transition to a visually distinct, low anode current mode at high applied voltages. Time resolved measurements of the anode current in the high current, low voltage mode revealed extreme oscillations at 3.5 kHz with the current nearly extinguishing during each period. Discharge current oscillations during high voltage, low current operation are minimal in contrast, though the dominant frequency remains the same. A high speed camera is used to discern the evolution of plasma luminosity through a typical cycle, with the geometry of the discharge chamber allowing shallow views of the ionization region to augment the typical axial imaging. Anode current is measured simultaneously and matched to representative cycles of image intensity inside the discharge chamber. The time resolved thruster dynamics are then compared for a range of operating conditions under each of the observed modes. Trends in oscillation frequency, magnitude, growth rates and decay rates are presented. A strong correlation between luminous plasma regions and magnetic cusp locations is observed.
Identifying Multiple Cluster Structures in a Data Matrix

Abstract An aspect of cluster analysis which has been widely studied in recent years is the weighting and selection of variables. Procedures have been proposed which are able to identify the cluster structure present in a data matrix when that structure is confined to a subset of variables. Other methods assess the relative importance of each variable as revealed by a suitably chosen weight. But when a cluster structure is present in more than one subset of variables and is different from one subset to another, those solutions as well as standard clustering algorithms can lead to misleading results. Some very recent methodologies for finding consensus classifications of the same set of units can be useful also for the identification of cluster structures in a data matrix, but each one seems to be only partly satisfactory for the purpose at hand. Therefore a new more specific procedure is proposed and illustrated by analyzing two real data sets; its performances are evaluated by means of a simulation experiment.
An Unusual Presentation of Metastatic BK Virus-Associated Urothelial Carcinoma Arising in the Allograft, Persisting After Transplant Nephrectomy

We report a 32-year-old male 14 years post-living-related kidney transplant presenting with new-onset hematuria and BK viremia. He was found to have BK virus-associated urothelial carcinoma originating in the renal allograft with locally advanced disease and metastases to multiple sites. He also developed acute T-cell-mediated rejection in the setting of immunosuppression reduction for BK viremia prior to undergoing transplant nephrectomy. Eight months following transplant nephrectomy and immunosuppression cessation, distant metastases persisted with partial response to chemotherapy and immunotherapy. Here, we discuss this unique presentation and compare it with other BK virus-associated allograft carcinomas reported in the literature, in addition to discussing evidence for the role of BK virus in oncogenesis.
Safety of purified Vero cell rabies vaccine manufactured in Pakistan: a comparative analysis of intradermal and intramuscular routes

Abstract Background Rabies vaccines are conventionally given via the intramuscular (IM) route; however, switching the route of administration from IM to intradermal (ID) without affecting efficacy can be advantageous in terms of cost, dosing, and time. Hence, it is indispensable to evaluate its safety along different routes. This study was carried out to ascertain the frequency of adverse drug events (ADEs) and associated factors, as well as to compare safety based on the IM and ID routes. Methods A prospective observational study was carried out on 184 individuals with rabies exposure. The vaccination schedules for post-exposure prophylaxis (PEP) included 0.2 milliliter (mL) of purified Vero cell rabies vaccine (PVRV) administered ID at two different sites with 0.1 mL each on days 0, 3, and 7 in first group (3-dose regimen ID) and 0.5 mL administered IM on days 0, 3, 7, 14, and 28 in the second group (5-dose regimen IM). The safety of the vaccines was determined by reviewing ADEs during physical examinations and follow-up. ADEs were characterized by local and systemic effects. Results Of the total, 99 (53.80%) patients reported ADEs. Those who reported local and systemic ADEs were 80 (43.48%) and 59 (32.06%), respectively, while simultaneous occurrence was reported in 40 (40.40%) patients. The most frequent local ADE (76; 41.30%) reported was pain, followed by erythema (18; 9.78%). Additionally, fever had the highest proportion (25; 13.59%) for systemic effects, followed by headache (15; 8.15%). The patients reported with ADEs by the IM and ID routes were comparable (p >.05). Similarly, both local and systemic effects were also comparable (p >.05). Conclusion Half of the study participants reported ADEs. Almost similar proportions of local and systemic effects were observed. Likewise, the ADEs recorded were comparable for both routes. PVRV carries very low safety concerns with either route for administration.
Current and emerging pharmacotherapy for respiratory syncytial virus (RSV) infection in infants

ABSTRACT Introduction Respiratory syncytial virus (RSV) is a common respiratory virus with a huge impact on patients, the healthcare system, and society worldwide. Very few effective chances of prevention and treatment of RSV infection are available. Areas covered In this paper, knowledge on RSV characteristics and current stage of development of new pharmacological measures against this virus are discussed. Expert opinion In recent years, the structure of RSV was explored in depth and several pharmacologic measures potentially effective for prevention and treatment of RSV infection and disease were identified. These new measures have the aim to overcome the limitations of palivizumab and ribavirin. Strategies to protect infants through immunization of pregnant women and/or the use of more effective monoclonal antibodies were developed. At the same time, it was defined which vaccines could be administered to unprimed infants to avoid the risk of enhanced respiratory disease and which vaccines could be effective in older patients and in subjects with reduced immune system efficiency. Finally, a great number of new antiviral drugs targeting the RSV proteins that allow RSV entering host cells or regulate virus replication were produced. Although further studies are needed, some preparations seem effective and safe, making the future of RSV infection prevention and treatment less gloomy.
Sleep restriction between consecutive days of exercise impairs sprint and endurance cycling performance

The study aim was to determine the effect of sleep restriction (3 h) between consecutive days of exercise on sprint and endurance cycling performance, wellness, and mood. A total of 10 well‐trained males performed 2 consecutive‐day trials separated by a normal night sleep (control [CONT]; mean [SD] sleep duration 3.0 [0.2] h) or sleep restriction (RES; mean [SD] sleep duration 3.0 [0.2] h). Experimental trials included a 90‐min fixed‐paced cycling bout and the respective sleep conditions on Day 1, followed by two 6‐s peak power (6‐s PP) tests, a 4‐ and 20‐min time trial (TT) on Day 2. Profile of Mood States (POMS) and wellness questionnaires were recorded on Day 1 and Day 2. Blood lactate and glucose, heart rate (HR), and rating of perceived exertion were recorded throughout Day 2. Power output (PO) was significantly reduced for RES in the 6‐s PP trial (mean [SD] 1159 [127] W for RES versus 1250 [186] W for CONT; p = 0.04) and mean PO during the 20‐min TT (mean [SD] 237 [59] W for RES versus 255 [58] W for CONT; p = 0.03). There were no differences for HR, lactate and glucose, or POMS between CONT and RES in all experimental trials (p = 0.05–0.89). Participants reported a reduction in overall wellness prior to exercise on Day 2 following RES (mean [SD] 14.5 [1.6] au) compared to CONT (mean [SD] 16 [3.0] au; p = 0.034). Sleep restriction and the associated reductions in wellness, reduce cycling performance during consecutive days of exercise in a range of cycling tests that are relevant to both track and road cyclists.
Consumer attitudes and behaviors toward more sustainable diets: a scoping review

Abstract There is an urgent need to move toward more sustainable diets. Although this will require radical and systemic changes across food systems, altering consumer ideologies and practices is essential to garner support for such actions. In this scoping review, the evidence on consumers’ attitudes and behaviors toward more sustainable diets is synthesized and a range of factors, considerations, and proposed strategies are presented that can contribute to building the societal-level support for urgent and systems-level changes. The findings suggest that consumers, insofar as they are interested in sustainability and have the capacity to engage with the concept, primarily approach the concept of sustainable diet from a human health perspective. However, the interconnectedness of human health and well-being with environmental health is poorly understood and under-researched in the context of consumer behaviors and attitudes toward sustainable diets. This highlights the need for (1) sustained efforts from public health professionals to encourage a realignment of the term sustainable diet with its multidimensional meaning by championing an ecological public health approach in all efforts aimed at promoting more sustainable consumption, from awareness raising to policy development; (2) a broader research lens focused on the multidimensional concept of sustainability in the literature exploring consumer attitudes and behaviors; and (3) the development of multidisciplinary, clear, and evidence-based sustainable-eating messages, including holistic sustainable dietary guidance, to address knowledge gaps, minimize conflicting narratives, and build consumer agency. The findings contribute to understanding how support can be generated for the necessary structural and system-level changes required to support behavior change.
Working from home and subsequent work outcomes: Pre-pandemic evidence

Frequent working from home (WFH) may stay as a new work norm after the COVID-19 pandemic. Prior observational studies on WFH and work outcomes under non-pandemic circumstances are mostly cross-sectional and often studied employees who worked from home in limited capacity. To provide additional insights that might inform post-pandemic work policies, using longitudinal data collected before the COVID-19 pandemic (June 2018 to July 2019), this study aims to examine the associations between WFH and multiple subsequent work-related outcomes, as well as potential modifiers of these associations, in a sample of employees among whom frequent or even full-time WFH was common (N = 1,123, Meanage = 43.37 years). In linear regression models, each subsequent work outcome (standardized score was used) was regressed on frequencies of WFH, adjusting for baseline values of the outcome variables and other covariates. The results suggested that WFH for 5 days/week versus never WFH was associated with subsequently less work distraction (ß = -0.24, 95% CI = -0.38, -0.11), greater perceived productivity/engagement (ß = 0.23, 95% CI = 0.11, 0.36), and greater job satisfaction (ß = 0.15, 95% CI = 0.02, 0.27), and was associated with subsequent work-family conflicts to a lesser extent (ß = -0.13, 95% CI = -0.26, 0.004). There was also evidence suggesting that long work hours, caregiving responsibilities, and a greater sense of meaningful work can all potentially attenuate the benefits of WFH. As we move towards the post-pandemic era, further research will be needed to understand the impacts of WFH and resources for supporting employees who work from home.
Canopy-top measurements do not accurately quantify canopy-scale leaf thermoregulation

Leaf traits and climate interact via energy budgets, enabling leaf temperature ( T leaf ) to depart from ambient air tempera - ture ( T air ) (1). When quantified as the slope β of T leaf vs. T air , three types of thermoregulatory behavior are possible: lim - ited homeothermy ( β < 1), poikilothermy ( β = 1)
Heterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion

Significance Amino acid substitutions within the cervid prion protein (PrP) can decrease susceptibility to chronic wasting disease, generally with more prominent effects in homozygous animals. Using novel gene-targeted mouse models expressing S138N reindeer/caribou PrP, we demonstrate subclinical infection with prion seeding activity in spleen and fecal prion shedding in heterozygous 138SN and homozygous 138NN mice. A lower percentage of heterozygous 138SN-PrP than homozygous 138NN-PrP expressing mice harbored seeding-efficient prions in tissues. This is caused by dominant-negative interference of the PrP variants occurring only if they are coexpressed. Our findings are relevant to inform conservation efforts for caribou, an endangered species in North America. Furthermore, our study provides new mechanistic insights into genetic resistance and dominant-negative interference of conversion-competent PrP variants.
Evidence for heterothermic endothermy and reptile-like eggshell mineralization in Troodon, a non-avian maniraptoran theropod

Significance The dinosaur–bird transition is among the most fascinating events in evolutionary history, but several biological aspects such as changes in reproductive system, nesting strategy, and body temperature are still poorly understood. Dual clumped isotope thermometry (Δ47 and Δ48) can shed light on these biological aspects in fossils. Our results show that eggshells of modern reptiles and birds differ in their isotopic compositions. Interestingly, analyses of eggshells of Troodon, a non-avian theropod, reveal that it retained a slower, reptile-like mineralization to produce its eggs, despite having already evolved the capacity of changing its body temperature (heterothermic endothermy) like modern birds. Our findings also suggest that Troodon possessed two functional ovaries and that their nests were shared by multiple females.
The impact of incorporating surgical simulation into trichiasis surgery training on operative aspects of initial live-training surgeries.

BACKGROUND While surgical simulation is regularly used in surgical training in high-income country settings, it is uncommon in low- and middle-income countries, particularly for surgical training that primarily occurs in rural areas. We designed and evaluated a novel surgical simulator for improving trachomatous trichiasis (TT) surgery training, given that trichiasis is mostly found among the poorest individuals in rural areas. METHODOLOGY/PRINCIPAL FINDINGS TT surgery programs were invited to incorporate surgical simulation with a new, high fidelity, low-cost simulator into their training. Trainees completed standard TT-surgery training following World Health Organization guidelines. A subset of trainees received three hours of supplemental training with the simulator between classroom and live-surgery training. We recorded the time required to complete each surgery and the number of times the trainer intervened to correct surgical steps. Participants completed questionnaires regarding their perceptions. We also assessed trainer and trainee perceptions of surgical simulation training as part of trichiasis surgery training. 22 surgeons completed standard training and 26 completed standard training plus simulation. We observed 1,394 live-training surgeries. Average time to first live-training surgery completion was nearly 20% shorter the simulation versus the standard group (vs 34.4 minutes; p = 0.02). Trainers intervened significantly fewer times during initial live-training surgeries in the simulation group (2.7 vs. 4.8; p = 0.005). All trainers indicated the simulator significantly improved training by allowing trainees to practice safely and to identify problem areas before performing live-training surgeries. Trainees reported that simulation practice improved their confidence and skills prior to performing live-training surgeries. CONCLUSIONS A single high-fidelity surgical simulation session can significantly improve critical aspects of initial TT surgeries.
Hyperlipasemia in dogs with acute kidney injury treated with and without hemodialysis

Abstract Background Hyperlipasemia has been reported in dogs with acute kidney injury (AKI) but associations with AKI severity, hemodialysis (HD) treatment, and outcome have not been extensively evaluated. Objectives Investigate the prevalence and clinical relevance of hyperlipasemia in dogs with AKI, treated with and without HD. Animals Client‐owned dogs (n = 125) with AKI. Methods Retrospective data extraction from medical records, including signalment, cause of AKI, duration of hospitalization, survival, plasma creatinine concentration, and 1,2‐o‐dilauryl‐rac‐glycero‐3‐glutaric acid‐(6′‐methyresorufin) ester (DGGR) lipase activity at admission and throughout hospitalization. Results A DGGR‐lipase activity >3× the upper reference limit (URL) was found in 28.8% and 55.4% of dogs at admission and during hospitalization, respectively, but only 8.8% and 14.9% of dogs, respectively, were diagnosed with acute pancreatitis. Hyperlipasemia >10 × URL was observed in 32.7% of dogs during hospitalization. The DGGR‐lipase activity was higher in dogs with International Renal Interest Society (IRIS) Grades 4–5 than Grades 1–3, but correlation between DGGR‐lipase activity and creatinine concentration was poor (r s = .22; 95% confidence intervals [CI], 0.04–0.38). Treatment with HD was not associated with DGGR‐lipase activity independent of IRIS grade. Survival to discharge and 30 days after admission was 65.6% and 59.6%, respectively. High IRIS grades (P = .03) and high DGGR‐lipase activity at admission (P = .02) and during hospitalization (P = .003) were associated with nonsurvival. Conclusions and Clinical Importance Hyperlipasemia is frequent and often marked in dogs with AKI despite only a minority being diagnosed with pancreatitis. Hyperlipasemia is associated with AKI severity but not independently with HD treatment. High IRIS grade and hyperlipasemia were associated with nonsurvival.