Miracle-dz/UniFAR-FTUs huggingface dataset:
Synergistic Effect of Toceranib and Nanohydroxyapatite as a Drug Delivery Platform—Physicochemical Properties and In Vitro Studies on Mastocytoma Cells

A new combination of Toceranib (Toc; 5-[(5Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrole-3-carboxamide) with nanohydroxyapatite (nHAp) was proposed as an antineoplastic drug delivery system. Its physicochemical properties were determined as crystallinity, grain size, morphology, zeta potential and hydrodynamic diameter as well as Toceranib release. The crystalline nanorods of nHAp were synthesised by the co-precipitation method, while the amorphous Toceranib was obtained by its conversion from the crystalline form during nHAp–Toc preparation. The surface interaction between both compounds was confirmed using Fourier-transform infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV–Vis) and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS). The nHAp–Toc showed a slower and prolonged release of Toceranib. The release behaviour was affected by hydrodynamic size, surface interaction and the medium used (pH). The effectiveness of the proposed platform was tested by comparing the cytotoxicity of the drug combined with nHAp against the drug itself. The compounds were tested on NI-1 mastocytoma cells using the Alamar blue colorimetric technique. The obtained results suggest that the proposed platform shows high efficiency (the calculated IC50 is 4.29 nM), while maintaining the specificity of the drug alone. Performed analyses confirmed that nanohydroxyapatite is a prospective drug carrier and, when Toceranib-loaded, may be an idea worth developing with further research into therapeutic application in the treatment of canine mast cell tumour.
Project Initiation, Monitoring and Control on Performance of the Regional Pastoral Livelihoods Resilience Project, Kenya

: The performance of Regional Pastoral Livelihoods Resilience Project-Kenya is informed by how well the project management understands and manages the key project life cycle concept. Literature provides that over 40% of the projects fail to perform because of lack of poor conceptualization of the project life cycle concept. Thus, the link between project life cycle management and performance of RPLRP-Kenya was brought out in this inquiry. Specifically, the focus of the inquiry was on project initiation and project monitoring & control in relation to performance of RPLRP-Kenya. The accessible target population of the study were 289 National Project Coordinating Unit, County Coordinating Unit, Community leaders, representatives from the Ministry of Agriculture, Livestock & Fisheries, representatives from the ministry of National Treasury and beneficiaries of the RPLRP-Kenya which were the unit of analysis of the study. The study adopted stratified random sampling to select 165 respondents. The study gathered primary data using questionnaires and interviews. Reliability and validity of the instruments was determined through a pilot study. The analysis of the findings was conducted using descriptive statistics (means and standard deviations) and regression analysis. Before conducting regression analysis, the study conducted diagnostic tests that covered normality test, multicollinearity test and heteroscedasticity. Tabulation and visual aids helped in presenting the evidence of the inquiry. It was shown that project lifecycle management and performance are significantly interconnected. The inquiry came to the conclusion that project lifecycle management significantly shapes the ability of projects to perform. The study recommended that the policy makers in the ministry of Ministry of Agriculture, Livestock & Fisheries should formulate progressive policies that support M&E of other activities RPLRP-Kenya so as to enhance its performance.
Isolation of Antibacterial Nano-Hydroxyapatite Biomaterial from Waste Buffalo Bone and Its Characterization

Hydroxyapatite nanoparticles were isolated from a biowaste, buffalo bone, via the thermal decomposition method. The resulting white powdered material was characterized by Fourier Transformed Infrared (FTIR) spectroscopy, X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive X-ray (EDX) analysis. The FTIR spectra confirmed that a heat treatment of the bone powder at the temperature at or above 1223 K removed the organic moieties leading to the formation of a pure inorganic biomineral. The XRD analyses showed that the obtained material was nanocrystalline HAp (nano-HAp) with an average grain diameter of 25 nm, while their rod-shaped particles with their tightly agglomerated morphology were confirmed by the SEM analysis. Besides Calcium (Ca), Phosphorous (P), and Oxygen (O), trace amounts of Aluminum (Al), Magnesium (Mg), Copper (Cu), Zirconium (Zr) and Carbon (C) were also found by EDX analysis. Antibacterial activity of nano-HAp against six standard isolates was investigated by the agar well diffusion method and found to be more susceptible to Acinetobacter baumannii while other standard strains such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus showed lesser susceptibility and no antibacterial activity was noticed against Salmonella typhi and Methicillin resistant Staphylococcus aureus (MRSA) with the analysed concentration of nano-HAp suggesting its potential application in biomedical fields.
Integrative Metabolomic Characterization Reveals the Mediating Effect of Bifidobacterium breve on Amino Acid Metabolism in a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is commonly accompanied by global alterations in metabolic profiles, resulting in cognitive impairment and neuroinflammation in the brain. Using ultraperformance liquid chromatography-mass spectrometry, we performed integrative untargeted metabolomic analysis of metabolite alterations in the serum and hippocampal tissues of amyloid-β (Aβ)-injected AD model mice and sham controls. Multivariate analysis revealed that a Bifidobacterium breve CCFM1025 intervention significantly restored the differential metabolites induced by Aβ-injection, resulting in B. breve CCFM1025 serum and hippocampal metabolomes clustering between control and model mice. Furthermore, pathway and metabolite set enrichment analysis found that these altered metabolites were predominantly linked to amino acid metabolism. Overall, the integrative metabolome analysis indicated that B. breve CCFM1025 supplementation could modulate serum and hippocampal metabolomes in the early stage of AD, with amino acids as a potential driver.
System Outage Performance of SWIPT Enabled Full-Duplex Two-Way Relaying With Residual Hardware Impairments and Self-Interference

This article investigates the joint impact of residual hardware impairments (RHIs) and residual self-interference (RSI) at all transceivers on the system outage performance for a simultaneous wireless information and power transfer (SWIPT) enabled full-duplex two-way decode-and-forward (DF) relay network. Considering a time switching scheme at the relay node, we derive the system outage probability in a closed-form, and further identify the overall system ceiling (OSC) effect caused by only RHIs. More specifically, when the data rate exceeds the OSC threshold determined by the RHIs level, the communication of the entire network ceases no matter what the signal-to-noise ratio is. In addition, we derive the achievable diversity gain of the considered network, and demonstrate that the diversity gain always equals zero due to the existence of RHIs and RSI. Finally, numerical simulations are provided to study the influence of multifarious network parameters on the system outage performance and the performance gap between the DF and amplify-and-forward strategies.
EPIDEMIOLOGY OF PELOTA VALENCIANA ESTUDIO EPIDEMIOLÓGICO EN PELOTA VALENCIANA

This paper consists of an epidemiological study of pelota valenciana intended to analyse playersneeds and to improve their sporting life. To that end, 92 players, 51 of them professional, took part in the survey. Epidemiological and personal data were gathered. The results show that 96.7% of players get injured, the highest injury rate being found in the hands (66.0%), shoulders (61.5%) and ankles (39.6%). It was also noticed that professional players have significantly more injuries in the dominant ankle, shoulder, elbow and hand than amateur players (p<0.05). To reduce the high injury incidence, better hand
Bacterial Contamination of Escherichia coli in Long Beans at Traditional Markets

Escherichia coli (E. coli) bacteria may contaminating uncooked food and cause food poisoning disease. Long beans (Vigna sinensis L) is one of the vegetable that consumed by people in raw (uncooked) and often traded in traditional markets. Many traditional markets do not meet sanitation requirements and many sellers do not perform good personal hygiene. These situation can potentially to cause bacterial contamination of vegetables sold in traditional markets. There has been no research examining E. coli contamination in long beans that sold at traditional markets in Jember.The purpose of this study to prove the contamination of E. coli bacteria in long beans at traditional markets in Jember. The research method uses an observational descriptive design with the cross sectional approach. Research places in eight traditional markets in Jember Regency and Microbiology Laboratory, Faculty of Medicine, University of Jember. The samples used amounted to 40 long beans purchased from 40 traditional market traders. The microbiological examination is performed using the most probable number (MPN) method, namely presumptive test and completed test. The results showed from the presumptive test all of 40 samples (100%) contaminated with coliform bacteria. After completed tests, 36 out of 40 samples (90%) were found contaminated by E. coli. The majority of long beans sold in traditional markets have been contaminated by E. coli bacteria.
Social and Policy Determinants of COVID-19 Infection Across 23 Countries: An Ecological Study

Objectives This study aimed to identify the social and policy determinants of coronavirus disease 2019 (COVID-19) infection across 23 countries. Methods COVID-19 indicators (incidence, mortality, and fatality) for each country were calculated by direct and indirect standardization. Multivariable regression analyses were used to identify the social and policy determinants of COVID-19 infection. Results A higher number of doctors per population was related to lower incidence, mortality, and fatality rates of COVID-19 in 23 countries (β=−0.672, −0.445, and −0.564, respectively). The number of nurses/midwives per population was associated with lower mortality and fatality rates of COVID-19 in 23 countries (β=−0.215 and −0.372, respectively). Strengthening of policy restriction indicators, such as restrictions of public gatherings, was related to lower COVID-19 incidence (β=−0.423). A national Bacillus Calmette–Guérin vaccination policy conducted among special groups or in the past was associated with a higher incidence of COVID-19 in 23 countries (β=0.341). The proportion of the elderly population (aged over 70 years) was related to higher mortality and fatality rates (β=0.209 and 0.350, respectively), and income support was associated with mortality and fatality rates (β=−0.362 and −0.449, respectively). Conclusions These findings do not imply causality because this was a country-based correlation study. However, COVID-19 transmission can be influenced by social and policy determinants such as integrated health systems and policy responses to COVID-19. Various social and policy determinants should be considered when planning responses to COVID-19.
Use of metalaxyl against some soil plant pathogens of the class Peronosporomycetes – A review and two case studies

Upon its discovery and implementation in plant protection, metalaxyl became one of the most important fungicides against Phytophthora infestans, but its efficiency has also been proven against other soil pathogens of the class Peronosporomycetes. The most important genus – Phytophthora comprises more than 150 plant pathogens, which cause significant losses in crop production or damage to natural plant associations. Many species of related genera Pythium, Phytopythium and Globisporangium have a similar ability as the species of Phytophthora. Those pathogens are able to quickly spread in wet soils by actively movable zoospores or in the air by means of zoosporangia; they are able to persist in an environment for long periods once they are introduced into the locality, having durability from their resting structures (chlamydospores, hyphal swelling and oospores). Metalaxyl has proven to be very efficient against these pathogens. However, shortly after its release, the rapid development of resistance against this compound was recorded in many species of the class Peronosporomycetes. Such easily developed resistance is due to the monogenic nature of the resistance, which also determines any anti-resistant strategies. The solution of this issue rests in the cautious use of metalaxyl, with consideration given to these strategies, and should be based also on precise information about the environment and the present pathogenic agents.
A STRATEGIC ANALYSIS OF E-BUSINESS ADOPTION AND ENERGY COMPANIES' PERFORMANCE

Acest articol prezintă o nouă concepţie asupra nivelului de adoptare a Internetului in realizarea afacerilor, se demonstrează astfel că utilizarea acestei facilităţi in derularea proceselor organizaţionale poate conduce la o abordare distinctă si oferă metrica necesară pentru măsurarea si dezvoltarea performanţelor companiilor din domeniul energiei. Aplicaţiile de e-business pot fi utile in special in colectarea si transmiterea de informaţii atunci când incertitudinea pieţei este mare. Constatările autorilor oferă un cadru pentru un studiu mai riguros al performanţelor companiilor din domeniul energie si e-business. Realizarea de achiziţii electronice necesită generarea datelor si schimbul lor prin medii electronice compatibile pentru afaceri. This article presents a new conceptualization of e-business adoption intensity, demonstrates how e-business adoption across processes can be empirically distinguished, and provides the corresponding scales for measurement and to develop energy companies’ performance. E-business applications may be particularly useful in collecting and transmitting marketplace information when market uncertainty is high. The authors’ findings provide the foundation for a more rigorous study of e-business and energy companies’ performance. E-procurement can call for compatible electronic data generation and exchange interfaces across businesses.
METTL21A, a Non-Histone Methyltransferase, Is Dispensable for Spermatogenesis and Male Fertility in Mice

Protein methyltransferases play various physiological and pathological roles through methylating histone and non-histone targets. Many histone methyltransferases have been reported to regulate the development of spermatogenic cells. However, the specific function of non-histone methyltransferases during spermatogenesis remains unclear. In this study, we found that METTL21A, a non-histone methyltransferase, is highly expressed in mouse testes. In order to elucidate the role of METTL21A in spermatogenesis, we generated a Mettl21a global knockout mouse model using CRISPR/Cas9 technology. Unexpectedly, our results showed that knockout males are fertile without apparent defects in the processes of male germ cell development, including spermatogonial differentiation, meiosis, and sperm maturation. Furthermore, the ablation of METTL21A does not affect the expression and localization of its known targeting proteins in testes. Together, our data demonstrated that METTL21A is not essential for mouse spermatogenesis and male fertility.
Tactical Masters Athletes: BMI Index Classifications

Understanding the nexus between aging, physical activity, and obesity has been a source of ongoing investigation. A considerable amount of research has focused on Masters athletes in this regard, suggesting a beneficial relationship between Masters sport participation and a healthy body mass index (BMI). Some consider Active Duty military personnel as tactical athletes. As such, it is of interest to determine if aging Active Duty military personnel (or Masters Tactical Athletes) might have a similar BMI as other Masters athletes (MA). As such, this investigation examined previously recorded data of Active Duty Enlisted United States Marines (n = 402, male, 46–50 years old). The BMI of the Marines was stratified into categories of: underweight, normal, overweight, and obese. The Marines obesity prevalence was compared to US adult males (40–59 years) as well as male North American MA who competed at the 2009 Sydney World Masters Games. The Marines obesity prevalence was significantly lower than US adult males (p < 0.001) and those MA that competed in softball (p < 0.001); however, it was similar to MA that competed in football, track/field, swimming, and volleyball (p > 0.05). The average Marine BMI = 26.7 kg/m2 was similar to MA who competed in football, swimming, and volley ball (p > 0.05); however, it was higher than MA who competed in track/field (p < 0.05) and lower than MA who played softball (p < 0.05). It should be noted that the average BMI for the Marines and all MA sport categories were classified as being overweight. Within the parameters of this investigation, Tactical MA (i.e., aging US Marines) enjoy a similar beneficial BMI as other North American MA.
Predicting environmental problem-solving skills with a dynamic system in elementary education

Numerous environmental problems drive discussion to solve them. Students require environmental problem-solving skills to solve the existing problems. The study aimed to describe environmental problem-solving skills in Elementary Education. The research method is descriptive using a system dynamics approach. Instrument of Higher Order Thinking Skills (HOTS) and Pro-Environmental Behavior (PEB) used to measure students score in environmental topic. Sample was chosen by simple random sampling. The research used VENSIM software to create the modeling. The research results indicate that the score of the environmental problem-solving skills tends to increase due to the Higher Order Thinking Skills (HOTS) and Pro-Environmental Behavior (PEB). Moreover, there are other influencing factors including learning media and students’ activity in their environment. An increase of 5 points in the environmental problem-solving skills every year will be derived if the teachers perform various learning innovations. The research concludes that environmental problem-solving skills in low category and can be improve by various learning innovations.
Chain Mediation Model of Perceived Stress, Resilience, and Social Support on Coping Styles of Chinese Patients on Hemodialysis During COVID-19 Pandemic Lockdown

Background The recurrence of COVID-19 and the continuous escalation of prevention and control policies can lead to an increase in mental health problems. This study aimed to investigate the perceived stress, coping style, resilience, and social support among patients on maintenance hemodialysis (MHD) during the COVID-19 epidemic lockdown in China. Material/Methods This cross-sectional observational study enrolled 197 patients on MHD from the Guangdong Province Traditional Chinese Medical Hospital and the Hedong Hospital of Guangzhou Liwan District People’s Hospital during July 2021. AMOS 24.0 and PROCESS Macro 3.1 model 6 were used for analyses of moderating mediating effects. Results Perceived stress was negatively correlated with positive coping style (r=−0.305, P<0.001) and resilience (r=−0.258, P<0.001), whereas resilience (r=0.631, P<0.001) and social support (r=0.300, P<0.001) were positively correlated with positive coping style among patients on MHD. In the moderated mediating model, perceived stress had significant direct predictive effects on positive coping style (95% CI −0.33, −0.07), and perceived stress had significant indirect predictive effects on positive coping styles through resilience (95% CI −0.26, −0.06) or social support (95% CI 0.01, 0.06). Perceived stress had significant indirect predictive effects on positive coping style through both resilience and social support (95% CI −0.04, −0.01). Conclusions Perceived stress not only predicted coping style directly, but also indirectly predicted coping style through resilience and social support. Coping style was affected by internal and external factors during the COVID-19 pandemic lockdown period.
Conditioning Regimens in Patients with β-Thalassemia Who Underwent Hematopoietic Stem Cell Transplantation: A Scoping Review

The success of transplant procedures in patients with beta-thalassemia major (β-thalassemia) goes hand-in-hand with improvements in disease knowledge, better supportive care, discoveries in immunogenetics, increase in stem cell sources, and enhancement of conditioning regimens. The aim of this scoping review was to report the evolution of conditioning regimes for β-thalassemia hematopoietic stem cell transplantation. We performed a systematic search for all relevant articles published before July 2021, using the following Medical Subject Headings: “bone marrow transplantation”, “stem cell transplantation”, “allogeneic”, “thalassemia”, “β-thalassemia”, and “thalassemia major”. The final analysis included 52 studies, published between 1988 and 2021, out of 3877 records. The most common conditioning regimen was a combination of busulfan and cyclophosphamide, with successive dose adjustments or remodulation based on patient characteristics. Pre-transplant treatments, reductions in cyclophosphamide dosage, or the adoption of novel agents such as treosulphan all improved overall survival and thalassemia-free survival in transplant-related mortality high-risk patients. Conditioning regimes were modulated for those without a suitable fully matched sibling or unrelated donor, with encouraging results. Hematopoietic stem cell transplantation with haploidentical donors is currently available to virtually all patients with β-thalassemia. However, disparities in outcome are still present around the world. In developing and limited-resource countries, where most diagnoses are focused, transplants are not always available. Therefore, more efforts are needed to close this treatment gap.
Adoption level of green fodder production practices and constraints faced by the farmers of Rajasthan

Balanced feeding is essential to fully exploit the genetic potential of livestock. The green fodder availability for livestock in the arid region of Rajasthan is restricted to selected areas and seasons. The production and productivity of green fodder can be increased by ensuring adoption of production technology and by overcoming the constraints. The present study was conducted by interviewing 120 randomly selected green fodder crop cultivating farmers of Jodhpur district to know the adoption level and constraints experienced by them. Majority of the respondents either not adopted or partially adopted the improved cultivation practices of green fodder crops. Poor knowledge of green fodder cultivation technology, lack of awareness about importance of green fodder for animal health, inadequate irrigation facility or irregular supply of electricity for irrigation were the top three ranked constraints experienced by the respondents. The farmer participatory approach needs to be adopted by the extension agencies to disseminate green fodder production technologies for increasing the productivity of livestock resources of the study area.