Miracle-dz/UniFAR-FTUs huggingface dataset:
Comovement in GDP Trends and Cycles Among Trading Partners

It has long been recognized that business cycle comovement is greater between countries that trade intensively with one another. Surprisingly, no one has previously examined the relationship between trade intensity and comovement of shocks to the trend level of output. Contrary to the result for cyclical fluctuations, we find that comovement of shocks to trend levels of real GDP is significantly weaker among countries that trade intensively with one another. We also find that the influence of trade on comovement between shocks to trends has remained stable, or become stronger in recent decades, while the role of trade in generating cyclical comovement has diminished steadily over time. In short, we find that international trade relationships have a substantial impact on comovement of shocks to output trends across countries, and these effects stand in stark contrast to the conventional wisdom regarding cyclical comovement.
Reflex human papillomavirus DNA testing on residual liquid‐based (TPPT™) cervical samples

Liquid‐based ThinPrep technology has made reflex human papillomavirus (HPV) DNA testing possible. In the current study, the clinical performance of reflex HPV testing as an adjunct to routine ThinPrep testing (TPPT) and the impact of age on various test parameters in a predominantly high‐risk, minority population were evaluated retrospectively.
Present State of Goods and Services Tax (GST) Reform in India

To remove cascading effect of taxes and provide a common nation-wide market for goods and services, India is moving towards introduction of Goods and Services Tax (GST). Under the proposed indirect tax reform both Central and State Governments will have concurrent taxation power to levy tax on supply of goods and services. It is expected that the proposed regime will improve tax collection and minimize leakage, as both Central and State Tax Administrations will monitor and assess same set of taxpayers. There are several challenges before introduction of GST and these can be classified into two broad heads - a) GST Design and Structure related, and b) GST Administration and Institutional. On design related issues, broad consensus on choice of revenue neutral rates (RNRs), harmonization of GST rate(s) across States, harmonization of list of exempted and excluded goods and services and thresholds for mandatory GST registration across States are yet to be reached. Similarly, there are several issues involved in tax administration (between Central and State Tax Administrations and also across State Tax Administrations) which are not yet solved. Taking cognizance of discussion available in the public domain this paper attempts to provide a broad contour of the proposed GST regime and highlights major challenges which require immediate attention of the Governments.
Effectiveness of Ledipasvir/Sofosbuvir and Predictors of Treatment Failure in Members with Hepatitis C Genotype 1 Infection: A Retrospective Cohort Study in a Medicaid Population

BACKGROUND: The primary goal of therapy for patients with chronic hepatitis C virus (HCV) infection is eradication of HCV ribonucleic acid, which is predicted by achievement of sustained virologic response at 12 weeks (SVR12). Ledipasvir/sofosbuvir was approved by the FDA in 2014 and 2015 as a once-daily regimen for the treatment of HCV genotype 1 and HCV genotypes 4, 5, and 6, respectively. Although its efficacy has been demonstrated in randomized controlled trials, there is an unmet need for real-world effectiveness data and studies that assess the association of rates of SVR12 with specific clinical and demographic factors in the Medicaid population. OBJECTIVES: To (a) evaluate the effectiveness of HCV genotype 1 treatment with ledipasvir/sofosbuvir as measured by the rate of SVR12 overall and within the subgroups of 8-, 12-, and 24-week regimens and (b) identify predictors of treatment failure in the Massachusetts Medicaid (MassHealth) population. METHODS: This retrospective cohort study evaluated the rate of SVR12 among 796 MassHealth Primary Care Clinician and fee-for-service plan members who completed treatment with at least one 8-, 12-, or 24-week treatment with ledipasvir/sofosbuvir for HCV genotype 1 infection between October 10, 2014, and November 1, 2016. The following variables were evaluated to identify predictors of treatment failure: sex, history of treatment failure, cirrhosis, substance use disorder, human immunodeficiency virus coinfection, and concomitant use of interacting medications. The proportion of members who achieved SVR12 was calculated for the entire study population and stratified by treatment regimen. Chi-square tests were used to compare the proportion of members who achieved SVR12, stratified by clinical and demographic variables. RESULTS: SVR12 was achieved in 95% (756/796) of members. High proportions of members who received 8 weeks of treatment or 12 weeks of treatment without concomitant ribavirin achieved SVR12 (96.0% [285/297] and 95.7% [382/399], respectively). A slightly lower proportion of members who received 12 weeks of treatment with concomitant ribavirin or 24 weeks of treatment achieved SVR12 (89.9% [62/69] and 87.1% [27/31], respectively). The proportion of members who achieved SVR12 with each treatment regimen was consistent when stratified by clinical and demographic variables. None of the included variables were found to be associated with statistically significant differences in odds of treatment failure. CONCLUSIONS: In the Medicaid population of 1 state, treatment of HCV genotype 1 infection with ledipasvir/sofosbuvir was associated with a high rate of SVR12. The outcomes of treatment of HCV genotype 1 infection with ledipasvir/sofosbuvir in the Medicaid population are comparable with outcomes observed in other patient populations.
Venous congestion affects neuromuscular changes in pigs in terms of muscle electrical activity and muscle stiffness

Early detection of venous congestion (VC)-related diseases such as deep vein thrombosis (DVT) is important to prevent irreversible or serious pathological conditions. However, the current way of diagnosing DVT is only possible after recognizing advanced DVT symptoms such as swelling, pain, and tightness in affected extremities, which may be due to the lack of information on neuromechanical changes following VC. Thus, the goal of this study was to investigate acute neuromechanical changes in muscle electrical activity and muscle stiffness when VC was induced. The eight pigs were selected and the change of muscle stiffness from the acceleration and muscle activity in terms of integral electromyography (IEMG) was investigated in three VC stages. Consequently, we discovered a significant increase in the change in muscle stiffness and IEMG from the baseline to the VC stages (p < 0.05). Our results and approach can enable early detection of pathological conditions associated with VC, which can be a basis for further developing early diagnostic tools for detecting VC-related diseases.
SyncSpecCNN: Synchronized Spectral CNN for 3D Shape Segmentation Supplementary Material

A set of precomputed functional maps are used for SpecTN pretraining. We mentioned in the main paper that the functional map C from S to the average shape S̄ could be induced from the spatial correspondences between S and S̄, by the primal-dual relationship. Once we have the bases of S and S̄, as well as the rough spatial correspondences between them from the volumetric occupancy, the functional map can then be discovered by the approach proposed in [3]. To be specific, we use Bv to denote the volumetric reparametrization of graph Laplacian eigenbases B for each shape S, and use B̄v to denote the graph Laplacian eigenbases of S̄. Bv and B̄v both lie in the volumetric space and their spatial correspondence is natural to acquire. The functional map Cpre aligning Bv with B̄v could be computed through simple matrix multiplication Cpre = B̄ v Bv . The computed functional map will serve as supervision and SpecTN is pretrained to minimize the loss function ||C − Cpre||F . It is worth mentioning that, if the shapes under consideration are diverse in topology and geometry, i.e. shapes from different categories, aligning every shape to a single “average” shape might cause unwanted distortion. Therefore we leverage multiple “average” shapes {S̄i}i=1 and use a combination of their spectral domains as the canonical domain. Specifically, we assign each shape S to its closest “average” shape under some global similarity measurement (i.e. lightfield descriptor) and use {ai}i=1 to represent such assignment, namely ai = 1 if S is assigned to S̄i and ai = 0 otherwise. Also we use B̄vi to denote the spectral bases of S̄i. Then the functional mapCpre for each shape S could be computed through Cpre = [a1B̄v1 a2B̄v2 . anB̄vn]Bv . The SpecTN is pretrained to predict a functional map which only synchronizes spectral domain of each shape to its most similar “average” shape.
Reduction of aerosol dissemination in a dental area generated by high-speed and scaler ultrasonic devices employing the “Prime Protector”

The use of an external dome aerosol containment device (Prime Protector) is proposed to reduce the spread of particles within the dental office. Hence, the aim of our study was to compare the spread of bioaerosols generated by a High-speed Handpiece (HH) and an Ultrasonic Prophylaxis Device (UPD), with and without the Prime Protector dome (PP) by counting Colony Forming Units (CFU) of Lactobacillus casei Shirota, at different distances on the x and y axis. The PP was located considering the parallelism between the base of the dome and the frontal plane of the simulator, aligning the center of the mouth with the center of the dome. The PP dome measurements are 560.0mm x 255.0mm x 5mm. Petri dishes were placed at 0.5 m, 1 m and 1.5 m respectively. Aerosol generation in the laboratory environment was done three times with the following experimental groups 1) HH, 2) HH-PP, 3) UPD, 4) UPD-PP. Each dental device activation (HH and UPD) had a time frame of 2 minutes on the upper anterior teeth of the dental phantom with a liquid suspension containing Lactobacillus casei Shirota (YAKULT 0836A 0123; 1027F 0407). Air pressure and ventilation were parameterized. No separate high-volume evacuation used, nor was there any air removal attached to the dome. Results showed no significant difference between distance and axis in the CFU count. When means for devices and distances were compared between each of them all showed significant differences except for UPD and UPD-PP (p <0,004). In conclusion, external devices like Prime Protector could help decrease aerosol diffusion during high-speed handpiece activation. However, this dome does not replace the use of PPE inside dental clinics.
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. In this study, transcriptomics analysis revealed that both WNT5A and IL11 were significantly up-regulated in A549 cells expressing individual accessory proteins ORF6, ORF8, ORF9b or ORF9c from SARS-CoV-2 (Wuhan-Hu-1 isolate). IL11 is a member of the IL6 family of cytokines. IL11 signaling-related genes were also differentially expressed. Bioinformatics analysis disclosed that both WNT5A and IL11 were involved in pulmonary fibrosis idiopathic disease and functional assays confirmed their association with profibrotic cell responses. Subsequently, data comparison with lung cell lines infected with SARS-CoV-2 or lung biopsies from patients with COVID-19, evidenced altered profibrotic gene expression that matched those obtained in this study. Our results show ORF6, ORF8, ORF9b and ORF9c involvement in inflammatory and profibrotic responses. Thus, these accessory proteins could be targeted by new therapies against COVID-19 disease.
Effective VTE prophylaxis with enoxaparin after elective THR or TKR: a retrospective observational study

Abstract Background: Orthopedic patients are at the highest risk for venous thromboembolism (VTE). Nowadays, with VTE prophylaxis as a routine in patients undergoing total hip replacement (THR) and total knee replacement (TKR), fatal pulmonary embolism (PE) is rare and the rates of symptomatic VTE within 3 months dropped to 1.3%–10%, compared with the rates of 50%–70% before VTE prophylaxis implementation. In this study, we aim to evaluate the VTE prophylaxis and incidence in patients who underwent THR and TKR in Centro Hospitalar Universitário de Santo António (CHUdSA). Methods: We included 483 patients who underwent elective THR or TKR in CHUdSA from March 2019 to February 2020 and who were under enoxaparin as a VTE prophylaxis drug. All data related to prescribed enoxaparin were collected from the nationwide common electronic drug prescription system (PEM). Results: Of the 483 eligible patients, 192 (39.75%) underwent elective THR and 291 (60.25%) underwent TKR. Enoxaparin was prescribed for 31.86 ± 5.98 and 30.28 ± 5.97 days, on average, for the THR and TKR groups, respectively (P = .005). Patients completed, on average, 29.38 ± 8.12 days and 28.20 ± 7.32 days of VTE prophylaxis with enoxaparin in the THR and TKR groups, respectively (P = .098). The incidence of VTE was approximately 3.13% and 0.69% in the THR and TKR groups, respectively (P = .064). Conclusion: In CHUdSA, we usually prescribe enoxaparin 40 mg once daily for up to 35 days for VTE prophylaxis after THR or TKR. High therapeutic compliance rates resulted in very few events.
Effectiveness of repetitive influenza vaccination against SARS-CoV-2 infection among a cohort of health care workers in Portugal

Abstract Vaccination for influenza has been essential over the years to protect the most vulnerable populations. Moreover, it was recently suggested that influenza vaccination might confer some nonspecific immunity to other viruses and be associated with a lower risk for coronavirus disease 2019 (COVID-19) morbidity and mortality. Therefore, we aimed to assess the effectiveness of repetitive influenza vaccination against SARS-CoV-2 infection in a cohort of health care workers (HCWs). This study was conducted among HCWs at São João University Hospital Center (CHUSJ), Porto, Portugal, a tertiary reference hospital for diagnosis and therapy, one of the largest hospitals in the country with approximately 6000 HCWs. We analyzed databases for influenza vaccination conducted between 2012 and 2019 and COVID-19 laboratory testing retrieved from the first and last registered positive COVID test date before HCW's COVID-19 vaccination started. The study outcome was the incidence of the first SARS-CoV-2 infection, as determined by reverse transcription polymerase chain reaction (RT-PCR). Age and sex were considered potential confounders. We used multivariable Cox regression to estimate odds ratios. Neither the absolute number nor the proportion of influenza shots influenced the risk of getting infected by SARS-CoV-2 (adjusted odds ratio 1.02, 95% CI: 0.9–1.06 and 1.17 95% CI: 0.86–1.58, respectively). Similar findings were observed in most cases when the analysis was restricted by year. The findings from our retrospective observational analysis of a HCWs cohort failed to support any protective effect between repetitive influenza vaccination and SARS-CoV-2 infection.
The LQAC-4, last update of the Large Quasar Astrometric Catalogue

Abstract Thanks to their point-like structure and to their lack of significant proper motion, quasars represent the ideal objects for modeling quasi-inertial directions in space. For that reason the present primary conventional reference frame, the ICRF-2, is constructed from the set of the celestial coordinates of a sample of extragalactic objects, whose the very large majority are quasars. Thus any newly discovered quasar must be considered as a potential future ideal astrometric marker. Therefore compiling all the recorded quasars at a given epoch looks as a useful task. This constitutes the aim of the LQAC (Large Quasar Astrometric Catalogue). We present here the contents of the future release of this catalogue quoted as the LQAC-4, insisting on the related strategy of compilation. Preliminary results concerning the cross-identification with the Gaia DR1 catalogue are emphasized
The association between HIV infection and precancerous cervical lesion. A systematic review and meta‐analysis of case–control studies

The effect of human immunodeficiency virus (HIV) on precancerous cervical lesion is not consistent across studies. Besides to the variability in the presence of a significant association between HIV and precancerous cervical lesion, the reported strengths are inconsistent among studies that report a significant association. Therefore, we sought to determine the impact of HIV on women's risk of precancerous cervical lesion by conducting a systematic review and meta‐analysis of case–control studies in Ethiopia.
The genetic basis of ankylosing spondylitis : new insights into disease pathogenesis

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress. com/permissions.php The Application of Clinical Genetics 2014:7 105–115 The Application of Clinical Genetics Dovepress
Spermidine enhances chilling tolerance of kale seeds by modulating ROS and phytohormone metabolism

Chilling stress is an important constraint for kale seed germination and seedlings establishment. It is vital to develop an effective approach to enhance kale seed germination ability under chilling stress. The present study reported that spermidine (Spd) could improve seed chilling tolerance in two kale cultivars ‘Nagoya’ (MGW) and ‘Pigeon’ (BB) during germination. The results showed that MGW was cold tolerant with a 90.67% germination percentage (GP) under chilling stress, while BB was cold sensitive with a 70.67% GP under chilling stress. Spd content in MGW and BB seeds during seed germination were up-regulated and down-regulated by chilling stress, respectively. Besides, chilling stress apparently decreased the gibberellin (GA) and ethylene (ET) contents, while increased the levels of abscisic acid (ABA) and reactive oxygen species (ROS) in MGW and BB seeds during germination. Exogenous Spd application increased GA, ET contents and decreased ABA content through regulating the gene expressions of metabolic-related enzymes, thus effectively alleviating the low temperature damage on kale seed germination. Besides, Spd significantly increased the activities of superoxide dismutase (SOD) and peroxidase (POD), and reduced the levels of hydrogen peroxide (H2O2) and superoxide anion (O2·-). The present study demonstrated that endogenous Spd metabolism plays an important role in kale seed germination under chilling stress. The effect of exogenous Spd on the metabolism of endogenous Spd, GA, ABA, ET and antioxidant enzymes might be the important reason for promoting the kale seed vigor at low temperature.
Tethered Prominence-CME Systems Captured during the 2012 November 13 and 2013 November 3 Total Solar Eclipses

We report on white light observations of high latitude tethered prominences acquired during the total solar eclipses of 2012 November 13 and 2013 November 3, at solar maximum, with a field of view spanning several solar radii. Distinguished by their pinkish hue, characteristic of emission from neutral hydrogen and helium, the four tethered prominences were akin to twisted flux ropes, stretching out to the limit of the field of view, while remaining anchored at the Sun. Cotemporal observations in the extreme ultraviolet from the Solar Dynamics Observatory (SDO/AIA) clearly showed that the pinkish emission from the cool ( K) filamentary prominences was cospatial with the 30.4 nm He II emission, and was directly linked to filamentary structures emitting at coronal temperatures K in 17.1 and 19.3 nm. The tethered prominences evolved from typical tornado types. Each one formed the core of different types of coronal mass ejections (CMEs), as inferred from coordinated LASCO C2, C3, and STEREO A and B coronagraph observations. Two of them evolved into a series of faint, unstructured puffs. One was a normal CME. The most striking one was a “light-bulb” type CME, whose three-dimensional structure was confirmed from all four coronagraphs. These first uninterrupted detections of prominence-CME systems anchored at the Sun, and stretching out to at least the edge of the field of view of LASCO C3, provide the first observational confirmation for the source of counter-streaming electron fluxes measured in interplanetary CMEs, or ICMEs.
Observer-Based Adaptive Consensus for a Class of Nonlinear Multiagent Systems

This paper investigates an adaptive consensus problem of a class of nonlinear multiagent systems in which the states are unmeasurable and the dynamics of all agents are supposed to be in strict-feedback form with unknown time-varying control coefficients. Due to the presence of uncertain nonlinearities in agents’ dynamics, radial basis function neural networks are used to approximate the unknown nonlinear functions, and a neural-network-based observer is designed to estimate the unmeasured states. The adaptive observer-based protocols are based on the relative output information of neighbors, and are constructed by adopting the dynamic surface control technique. It is proved that practical consensus of the system can be achieved with the proposed protocols. A simulation example is given to show the effectiveness of the proposed method.
Channel coordination through quality improvement with brand halo effect

Product quality depends on the quality investment of the manufacturer and quality decisions of the supplier. Therefore, many firms and researchers pay considerable attention to supply quality management. Considering a supply chain that includes two competing suppliers and one manufacturer, this paper investigates the influences of competition and the “brand halo” effect on the quality strategies of channel members, and explores the potential coordinating power of the bilateral participation contract. Utilizing differential game theory, this paper compares and analyzes the quality strategies of all channel members under three different scenarios: (i) decentralized scenario within a subsidy program, (ii) integrated scenario, and (iii) bilateral participation contract. Our results confirm the following results. (1) The manufacturer may not grant a subsidy to the supplier if two final products are highly competitive. (2) Supply chain members are more likely to join the bilateral participation contract if the “brand halo” effect is large. (3) The bilateral participation contract can achieve perfect coordination if the competition is weak or if a transfer payment policy exists.