Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of continuous and single interscalene block for quality of recovery score following arthroscopic rotator cuff repair

Background: Continuous interscalene brachial plexus block (CISB) is well known to reduce postoperative pain and to improve patient satisfaction. However, the effect of CISB on the quality of postoperative recovery is unknown. We Compared the quality of recovery from arthroscopic rotator cuff repair in patients who received CISB or single interscalene brachial plexus block (SISB). Methods: This prospective non-randomized controlled trial with propensity score matching enrolled 134 patients undergoing arthroscopic surgery for rotator cuff repair. Each patient received an interscalene block before surgery. One group had a catheter insertion 30 min after the end of surgery and started patient-controlled regional analgesia (PCRA, n = 49). The other group received intravenous patient-controlled analgesia (IV-PCA, n = 85). The primary outcome was the quality of recovery (QoR-40) score. Also, postoperative analgesia, sleep quality, and postoperative complications were evaluated. Results: The two groups had similar QoR-40 score on postoperative day-1 (POD1), but the PCRA group had a significantly greater QoR-40 score on POD2 (156.0, IQR: 143.0, 169.0 vs. 171.0, IQR: 159.0, 178.0; p < 0.001). The IV-PCA group received more analgesics during the 2 days after surgery, especially during night-time, and had a higher prevalence of sleep disturbances. The time to first additional analgesics request was significantly longer in PCRA group (14 hours, 95% CI: 13–16 vs. 44 hours, 95% CI: 28–not applicable). The incidence of postoperative nausea and vomiting significantly lower in the PCRA group (16.3% vs 46.9%, p = 0.002). Conclusion: CISB showed a higher quality of recovery score than SISB with IV-PCA in arthroscopic rotator cuff repair, probably related to the effective analgesia, improved sleep quality, and reduced opioid-related complications.
JAK/STAT inhibition augments soleus muscle function in a rat model of critical illness myopathy via regulation of complement C3/3R

Critical illness myopathy (CIM) is a frequently observed negative consequence of modern critical care. Chronic Janus kinase (JAK)/signal transducer and activator of transcription activation impairs muscle size and function and is prominent following mechanical ventilation. We identify pSTAT‐3 activation in tibialis anterior of CIM patients, before examining the potential benefits of JAK1/2 inhibition in an experimental model of CIM, where muscle mass and function are impaired. CIM activates complement cascade and increased monocyte infiltration in the soleus muscle, which was ameliorated by JAK1/2 inhibition, leading to reduced muscle degeneration and improved muscle force. Here, we demonstrate that JAK1/2 inhibition augments CIM muscle function through regulation of the complement cascade.
Association Between Disturbed Sleep and Depression in Children and Youths

Key Points Question Is disturbed sleep associated with depression in children and youths? Findings In this meta-analysis of 16 studies including 27 073 patients, pooled estimates supported the role of disturbed sleep as a risk factor for depression in children and youths. Effect size estimates were small but statistically significant. Meaning This study suggests that disturbed sleep is a component of the multifaceted risk profile of depression and should be included in prevention programs as early as childhood.
The prognostic significance of del6q23 in chronic lymphocytic leukemia

Université de Montréal, Montreal, Quebec, Canada Groupe Québecois de Recherche sur la LMC et NMP (GQR LMC-NMP)/ Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Quebec Research Group, Montreal, Quebec, Canada Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada Segal Cancer Center, Jewish General Hospital, Montreal, Quebec, Canada Department of Oncology, McGill University, Montreal, Quebec, Canada McGill University Health Centre, Montreal, Quebec, Canada University of Quebec Center of Hematology and Oncology, Quebec, Quebec, Canada Division of Hematology, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada
Efficacy Of Pegylated Liposomal Doxorubicin-based Neoadjuvant Chemotherapy In Breast Cancer: A Single Center Experience.

PURPOSE Neoadjuvant chemotherapy using a doxorubicin-based regimen has recently become a common therapeutic option for operable breast cancer. This study aimed to investigate the efficacy of polyethylene glycol-coated liposomal doxorubicin (PLD)-based chemotherapy for breast cancer in neoadjuvant settings. METHODS A total of 227 female operable breast cancer patients who were diagnosed between January 2009 and December 2017 and completed neoadjuvant PLD-based chemotherapy were retrospectively included. The logistic regression analysis was used to determine the associations between pathologic complete response (pCR) and preoperative clinicopathological characteristics. The breast cancer recurrence rate was estimated using the survival analysis. RESULTS A higher pCR rate was found in the patients with clinically negative lymph nodes and HER2-enriched patients. Moreover, the patients who achieved pCR also had a better prognosis outcome. A recurrence rate of 11.5% (n=26) was observed during a median follow-up of 11.63 months, and the recurrence rate of the pCR group (2.04%; 95% CI = 0.29-13.62) was lower than the non-pCR group (14.62%; 95% CI = 10.12-20.87). Higher histological grade was also associated high pCR rate (52.0% vs 40.0%). CONCLUSION The use of PLD-containing chemotherapeutics in neoadjuvant settings might have benefits for non-metastatic operable breast cancer in Taiwanese females.
A retrospective study of treatment of genu valgum/varum with guided growth: Risk factors for a lower rate of angular correction

The rate of angular correction (ROAC) is very unpredictable and may be affected by various factors in the treatment of genu valgum and varum by means of guided growth. The purpose of this study was to assess the ROAC in cases from our institution and to identify risk factors associated with the occurrence of lower ROAC. We retrospectively reviewed the chart records of 68 patients undergoing guided growth with figure-eight plate for the correction of genu valgum and varum. Based on the data from these patients, the annual increment of physeal growth was calculated and compared with data from the Anderson chart. The associations between patient characteristics and ROAC were evaluated with the use of univariate logistic regression. The mean rate of femoral angular correction was 10.29 degrees/year, while the mean rate of tibial angular correction was 7.92 degrees/year. In a univariate logistic regression analysis, the variables associated with a higher risk of lower ROAC included non-idiopathic coronal deformity of the knee (odds ratio = 13.58, p < 0.001) and body weight at or above the 95th percentile for children (odds ratio = 2.69, p = 0.020). Obesity and non-idiopathic coronal deformity of the knee are risk factors for lower ROAC. It is still uncertain whether severity of deformity, race, and operative procedure have a substantial effect on the rate of correction. Level III evidence.
Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms

Abstract Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity (P < .05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies (P = .002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.
Phytoextraction of cadmium and zinc from a contaminated soil

To identify populations with the ability to accumulate heavy metals, approximately 300 accessions pertaining to 30 plant species were grown for 4 wk in a hydroponic media that approximated the nutrient and heavy metal composition of a soil contaminated with moderate levels of cadmium (Cd), copper (Cu), and zinc (Zn). The results indicated that several Brassica spp. exhibited moderately enhanced Zn and Cd accumulation. Selected accessions of Brassica juncea (L.) Czern, B. napus L. , and B. rapa L. were then grown in pots with heavy metal-contaminated soil to compare the Zn and Cd phytoextraction by these species to that of Thlaspi caerulescens J. & C. Presl, a known Zn and Cd hyperaccumulator, and two grass species, Agrostis capillaris L. and Festuca rubra L. The three Brassica spp. were the most effective in removing Zn from the contaminated soil, primarily because they produced more than 10 times the shoot biomass produced by T. caerulescens. When the soil was amended with Gro-Power, a commercial soil amendment that improves soil structure and fertility, removal of Zn by plant shoots doubled to more than 30 000 mg Zn pot -1 (4.5 kg). The results suggest that for phytoremediation of metal-polluted soils to be successful, a strategy should be considered that combines rapid screening of plant species possessing the ability to tolerate and accumulate heavy metals with agronomic practices that enhance shoot biomass production and/or increase metal bioavailability in the rhizosphere.
Successful biological control of winter moth, Operophtera brumata, in the northeastern United States.

Winter moth, Operophtera brumata, native to Europe, invaded the northeastern United States in the late 1990s, where it caused widespread defoliation of forests and shade trees ranging from 2,266 to 36,360 ha per year between 2003 and 2015 in Massachusetts. In 2005, we initiated a biological control effort based on the specialist tachinid parasitoid Cyzenis albicans, which had previously been introduced along with the generalist ichneumonid parasitoid Agrypon flaveolatum to control winter moth in Nova Scotia in the 1950s and British Columbia in the 1970s. Due to concerns of possible non-target impacts by A. flaveolatum, we focused entirely on the specialist C. albicans. Each year for 14 years, we collected several thousand individuals of C. albicans from British Columbia and released them in widely spaced sites in the northeastern United States. As of 2020, we had established C. albicans at 41 of 44 sites from coastal Maine to southeastern Connecticut. By 2016 winter moth densities (pupae/m2 ) had declined from 100-500 pupae/m2 to 0-10 pupae/m2 at six release sites at least 10 km apart and this was coincident with the onset of 10-40% parasitism. At one site in Wellesley, Massachusetts, the decline occurred in 2012 and winter moth densities have remained low for seven subsequent years. Defoliation in Massachusetts has been reduced to undetectable levels since 2016. DNA sequencing of the barcoding region of the mitochondrial gene CO1 confirmed that all C. albicans reared from winter moth matched the C. albicans collected from Vancouver Island and were distinct from parasitic flies (presumably a native species) reared from a native congener of winter moth, Bruce spanworm (O. bruceata). Successful establishment of C. albicans on winter moth represents a rare, if not the only, example of the biological control of a major forest defoliator that attacks a wide range of tree species anywhere in the world by the establishment of a single specialist natural enemy.
Iron pyrites as sulphur fertilisers

Abstract Elemental sulphur (S), fine-grained marcasite (Ma), and coarsegrained pyrite CPy) were compared as sulphur fertilisers on a grassclover pasture. Total S, sulphate S (S04-S), and total-N/total-S ratio (N/S)t,) were determined on grass and clover separates on three occasions-(harvests 3 (autumn), 5 (spring), and 6 (autumn—approximately 12, 20, and 25 months respectively, after laying down the trial. Responses to the fertilisers, at equivalent rates of sulphur, (180 kg/ha, 160 lb/ac), were Fine-grained marcasite thus showed a greater residual effect than clemental S. Coarse-grained pyrite was the least effective S fertiliser, but at the highest rate of 360 kg/ha (320 lb/ac) S its residual effect after 25 months was approximately equivalent to that from 180 kg/ha (160 lb/ac) of elemental S. The two autumn harvests were clover-dominant, the spring harvest grass-dominant, but the proportion of grass to clover was not significantly affected by the treatments. Total S and SO4-S were closely and linearly .
Effectiveness and Renal Safety of Tenofovir Alafenamide Fumarate among Chronic Hepatitis B Patients: Real‐World Study

Tenofovir alafenamide fumarate (TAF) has high plasma stability resulting in fewer renal adverse events compared to tenofovir disoproxil fumarate (TDF) in chronic hepatitis B (CHB) patients. We aimed to study the effectiveness and renal safety of TAF in a real‐world setting, in patients with or without compromised kidney function. CHB patients (Nucleos(t)ide Analogue [NA]‐naïve or experienced) who received TAF >1 year from 11 academic institutions as part of the Canadian Hepatitis B Network (CanHepB) were included. Kidney function was measured by estimated glomerular filtration rate (eGFR) as per Cockcroft‐Gault. Patients were followed for up to 160 weeks. Of 176 patients receiving TAF, 143 switched from NA (88% TDF), and 33(19%) were NA naïve. Majority of NA‐naïve patients (75%) achieved undetectable HBV DNA after one year of TAF treatment. Majority of patients with eGFR <60 mL/min who had renal deterioration during TDF (76%) reversed to eGFR increase after one year of TAF (p=0.009). Among patients with stage 2 chronic kidney disease (CKD) (eGFR 60–89), the estimated eGFR decline during TDF was halted after switching to TAF (p=0.09). NA‐experienced patients with abnormal ALT before TAF showed a significant decline after switching to TAF: −0.005 [−0.006 – −0.004] log10 ULN U/L/month, p<0.001). In CHB patients, TAF was safe, well‐tolerated and effective in this real‐world cohort. Switching to TAF led to improved kidney function, particularly in those with stage 2 CKD, which suggests that the indication for TAF in the guidelines could be extended to patients with an eGFR higher than 60 mL/min.
Identification and characterization of the adipogenesis in intramuscular and subcutaneous adipocytes of the goose (Anser cygnoides)

Abstract Chinese geese are domesticated from wild swan (Anser cygnoides), which have maintained a strong capacity of fat deposit. Fat mainly distributes subcutaneous, abdominal, intermuscular or intramuscular in poultry, and they display some special physiological and biochemical characteristics in different parts. This study aimed to characterize the adipogenesis in intramuscular (IM) and subcutaneous (SC) adipocytes of the goose. Here, IM and SC preadipocytes were isolated from the 26-day-old Yangzhou goose embryos, and subsequently induced them to differentiate into mature adipocytes. The results showed that SC preadipocytes grew a little faster than IM preadipocytes during the logarithmic multiplication phase (p < 0.05). Meanwhile, SC adipocytes accumulated more lipid than IM adipocytes during the differentiation process in vitro (p < 0.01). In addition, the expression level of key genes involved in adipogenesis, including peroxisome proliferator activated receptor γ/α (PPARγ/α), CCAAT/enhancer binding protein-α/β (C/EBPα/β), adipocyte fatty acid binding protein 4 (FABP4), and lipoprotein lipase (LPL) were detected. PPARγ, C/EBPα, FABP4, and LPL, were predominantly expressed in SC adipocytes, whereas C/EBPβ was highly expressed in IM adipocytes. Taken together, these results demonstrated that SC preadipocytes tended to grow faster and accumulate more lipid than IM adipocytes, and show greater potential for adipogenesis.
Characteristics of Dioxane Lignins Isolated at Different Ages of Nalita Wood (Trema orientalis)

Abstract Nalita (Trema orientalis) is one of the fastest growing trees in the tropical countries. The structural characteristics of lignin isolated at different ages of Nalita wood (Trema orientalis) by acidolytic dioxane method were examined by UV, FTIR, 1H‐NMR and 13C‐NMR spectroscopy, alkaline nitrobenzene oxidation, molecular weight determination, elemental and methoxyl analysis. The data were compared with aspen lignin. The structural analysis revealed that Nalita wood lignin is syringyl‐guaiacyl type. The methoxyl content in Nalita wood lignin was lower than aspen lignin. The C9 formulas for 30‐months‐old Nalita was C9H9.31O3. 13(OCH3)1.27, whereas that of aspen was C9H8.94O3. 15(OCH3)1.47. The weight average molecular weight of Nalita wood lignin was decreased from 36,500 to 25,500 with increasing tree age from 12 to 30 months, whereas weight average molecular weight of aspen was 20,000. Both alcoholic and phenolic hydroxyl group in Nalita wood lignin is lower than aspen lignin.
Effective nonapical left ventricular pacing with quadripolar leads for cardiac resynchronization therapy.

BACKGROUND Current guidelines recommend to avoid apical left ventricular (LV) pacing for cardiac resynchronization therapy (CRT). AIM We investigated the feasibility of non-apical pacing with current quadripolar LV lead technology. METHODS We analyzed consecutive patients who received CRT with a LV quadripolar lead. Post-implantation position of each electrode of the LV lead was designated as basal, mid, or apical. The pacing (PCT) and the phrenic nerve stimulation (PNS) thresholds were assessed for each electrode. RESULTS We enrolled 168 patients. Eight CRT-D were from Biotronik (with Sentus OTW QP lead), 98 from Boston Scientific (21 Acuity X4 Spiral, 77 Acuity X4 Straight leads), and 62 from St Jude Medical (with Quartet lead). The median [25-75 percentile] number of electrodes at non-apical segments per patient was: 3 [1-4] with Biotronik Sentus, 4 [3-4] with spiral-design Boston Scientific leads, 4 [3-4] with straight Boston Scientific, 3 [3-4] with St Jude Medical Quartet (P = 0.045). Three (38%) patients with Biotronik Sentus, 21 (100%) with spiral-design Boston Scientific, 69 (90%) with straight-design Boston Scientific, and 49 (79%) with St Jude Medical Quartet (P < 0.001) had at least one electrode located at non-apical segments linked with a PNS-PCT safety margin > 2 V. During the 6-months follow-up, PNS was detected in 4 patients and was eliminated with reprogramming. No significant changes in PCT were detected from baseline to follow-up. CONCLUSIONS Quadripolar leads allowed non-apical pacing with acceptable electrical parameters in the majority of CRT recipients, although dissimilarity appeared among currently available devices.
Agreement between the categorization of isolates of Aeromonas salmonicida and Yersinia ruckeri by disc diffusion and MIC tests performed at 22℃.

Standard disc diffusion and MIC test procedure were used to investigate the susceptibility of two hundred and fifty-one isolates collected from infected fish in France to florfenicol, oxolinic acid and tetracycline. The tests were performed at 22 ± 2℃ and for the 177 Yersinia ruckeri they were read after 24-28 hr incubation and for the 74 Aeromonas salmonicida isolates they were read after 44-48 hr. Applying epidemiological cut-off values to the susceptibility data generated in these tests, the isolates were categorized as wild-type or non-wild-type. The agent-specific categories into each isolate were placed on the basis of the data generated by the two methods were in agreement in 98% of the determinations made. It is argued that, with respect to categorising isolates, disc diffusion and MIC methods can be considered as equally valid at this temperature and after both periods of incubation.
Machine Learning for Prediction and Risk Stratification of Lupus Nephritis Renal Flare

Background: Renal flare of lupus nephritis (LN) is strongly associated with poor kidney outcomes, and predicting renal flare and stratifying its risk are important for clinical decision-making and individualized management to reduce LN flare. Methods: We randomly divided 1,694 patients with biopsy-proven LN, who had achieved remission after treatment, into a derivation cohort (n = 1,186) and an internal validation cohort (n = 508), at a ratio of 7:3. The risk of renal flare 5 years after remission was predicted using an eXtreme Gradient Boosting (XGBoost) method model, developed from 59 variables, including demographic, clinical, immunological, pathological, and therapeutic characteristics. A simplified risk score prediction model (SRSPM) was developed from important variables selected by XGBoost model using stepwise Cox regression for practical convenience. Results: The 5-year relapse rates were 39.5% and 38.2% in the derivation and internal validation cohorts, respectively. Both the XGBoost model and the SRSPM had good predictive performance, with a C-index of 0.819 (95% confidence interval [CI]: 0.774–0.857) and 0.746 (95% CI: 0.697–0.795), respectively, in the validation cohort. The SRSPM comprised 6 variables, including partial remission and endocapillary hypercellularity at baseline, age, serum Alb, anti-dsDNA, and serum complement C3 at the point of remission. Using Kaplan-Meier analysis, the SRSPM identified significant risk stratification for renal flares (p < 0.001). Conclusions: Renal flare of LN can be readily predicted using the XGBoost model and the SRSPM, and the SRSPM can also stratify flare risk. Both models are useful for clinical decision-making and individualized management in LN.
Association between pattern of team sport participation from adolescence to young adulthood and mental health

We examined relationships between pattern of team sport participation during the transition from adolescence to young adulthood (ie, non‐participants, initiators, discontinuers, sustainers) and indicators of mental health. Data on team sport participation and mental health from high school to young adulthood were drawn from the longitudinal NDIT study. After controlling for demographics, physical activity, and previous mental health, one‐way MANCOVA and ANCOVAs indicated that pattern of team sport participation was associated with stress, F(2,706) =8.28, p < . 01, and coping, F(2,706) = 10.66, p < . 01 in young adulthood. Compared to non‐participants (24% of sample) or those who discontinued team sport after adolescence (51%), individuals who sustained team sport participation from adolescence to young adulthood (22%) reported lower stress and better coping levels. Bivariate regression analysis indicated that, compared to non‐participants, team sport sustainers were less likely to experience panic disorder symptoms (OR =0.57, 95% CI [0.34, 0.94], p = .03). There were too few team sport initiators (2%) to be included in analyses. Sustained team sport participation during the transition from adolescence to young adulthood may promote better mental health. Further research is needed to ascertain causality and develop strategies to encourage individuals to join sport teams during adolescence and sustain participation while transitioning to young adulthood.