Miracle-dz/UniFAR-FTUs huggingface dataset:
Dimethyltryptamine: Endogenous Role and Therapeutic Potential

ABSTRACT N, N-dimethyltryptamine (DMT) is an indole alkaloid produced by a number of plants and animals, including humans. Its psychoactive effects were first described in 1956 by Stephen Szára, but have been exploited for centuries by South American indigenous populations in the form of ayahuasca. In the present review, we assess the state of the art regarding a putative role for endogenous DMT and potential clinical applications of ayahuasca and DMT. A review assessing the pharmacological profile of DMT and its clinical effects in humans was performed using the PubMed data base until 5 August 2018 with the words: ayahuasca and N,N-dimethyltryptamine. While the role of endogenous DMT remains unclear, ayahuasca has promising results in anxiety, depression and substance dependence. Since ayahuasca has a good safety profile, it is crucial to conduct further research aimed at developing new treatments for psychiatric disorders.
Clobetasol Modulates Adult Neural Stem Cell Growth via Canonical Hedgehog Pathway Activation

Sonic hedgehog (Shh) signaling is a key pathway within the central nervous system (CNS), during both development and adulthood, and its activation via the 7-transmembrane protein Smoothened (Smo) may promote neuroprotection and restoration during neurodegenerative disorders. Shh signaling may also be activated by selected glucocorticoids such as clobetasol, fluocinonide and fluticasone, which therefore act as Smo agonists and hold potential utility for regenerative medicine. However, despite its potential role in neurodegenerative diseases, the impact of Smo-modulation induced by these glucocorticoids on adult neural stem cells (NSCs) and the underlying signaling mechanisms are not yet fully elucidated. The aim of the present study was to evaluate the effects of Smo agonists (i.e., purmorphamine) and antagonists (i.e., cyclopamine) as well as of glucocorticoids (i.e., clobetasol, fluocinonide and fluticasone) on NSCs in terms of proliferation and clonal expansion. Purmorphamine treatment significantly increased NSC proliferation and clonal expansion via GLI-Kruppel family member 1 (Gli1) nuclear translocation and such effects were prevented by cyclopamine co-treatment. Clobetasol treatment exhibited an equivalent pharmacological effect. Moreover, cellular thermal shift assay suggested that clobetasol induces the canonical Smo-dependent activation of Shh signaling, as confirmed by Gli1 nuclear translocation and also by cyclopamine co-treatment, which abolished these effects. Finally, fluocinonide and fluticasone as well as control glucocorticoids (i.e., prednisone, corticosterone and dexamethasone) showed no significant effects on NSCs proliferation and clonal expansion. In conclusion, our data suggest that Shh may represent a druggable target system to drive neuroprotection and promote restorative therapies.
Measuring Test Anxiety With an Invariant Measure Across Genders: The Case of the German Test Anxiety Inventory

Since test performance is increasingly relevant in educational and occupational circles, the assessment of test anxiety—the phenomenological, physiological, and behavioral responses to the negative consequences that often emerge in evaluative situations—has become increasingly important to scholars and practitioners. One of the most widely employed scales to measure test anxiety in adolescents is the German Test Anxiety Inventory (in German: Prufungsangstfragebogen, PAF). The current study investigated the psychometric properties of the PAF when administered to Italian students. Our research found evidence of validity, supported the five-factor structure, and demonstrated the test’s good internal consistency. Moreover, the invariance of the dimensional structure across genders was examined. Overall, this study provides evidence for the reliability and validity of the PAF among Italian students.
Localising synthesised spatial audio filtered through a generalised HRTF

The presentation of spatial audio through binaural headphones requires initial filtering of the source signal through Head Related Transfer Functions (HRTFs) to provide localisation cues in the form of Interaural Time Differences (ITD), Interaural Intensity Differences (IID), and Spectral Cues. These cues naturally occur by sound interacting with an individual's physical features, such as the shape of the pinna, head and shoulders. Incorporating a generalised (non-individual) HRTF into an audio display is cost effective, however, non-individual HRTFs provide less identifiable cues for sound localisation. The purpose of the current study was to determine the localisation accuracy about the azimuth for 'white noise' signals that had been filtered through a generalised HRTF database using Sound Lab (SLAB). These data provide baseline information for subsequent experiments into optimising the presentation of sound using non-individual spatial cues. Eleven untrained participants listened to signals randomly presented at 10 degree increments in azimuth and -20, 0, and +20 degrees elevation. Azimuth localisation accuracy compared similarly with previous studies. Generalised HRTF effects caused a tendency for localisation estimates to bias considerably toward the ipsilateral side of the interaural axis. Approximately 20% of signals resulted in Front-Back confusions. Asymmetrical performance was observed, which possibly supports previous claims that spatial audio processing ability differs between cerebral hemispheres.
Feasibility of using a handheld tissue hardness meter to quantify uterine contractions and its clinical application for obstetric bleeding management

Abstract Postpartum haemorrhage (PPH) is a potentially life-threatening condition. Women undergoing caesarean section (CS) are at particular risk, and improvements in the management of PPH during CS are required. We investigated the use of a tissue hardness metre to quantify uterine contractions during CS with a view to its application for obstetric bleeding management. Fifty pregnant women at term who underwent elective CS were recruited. Using a tissue hardness metre, we measured uterine hardness twice during CS: after placental removal and before peritoneum closure. Each measurement was conducted at two standardised points: fundus and corpus uteri. Concurrently, obstetricians subjectively graded uterine contractions as weak, medium, or strong. The hardness metre accurately quantified the degree of uterine contraction assessed by the obstetricians, and could be an effective clinical tool for early recognition of intra-operative massive bleeding. IMPACT STATEMENT What is already known on this subject? Maintaining adequate uterine contraction leads to prevention of excessive blood loss, which decreases the incidence and severity of PPH. However, the assessment of uterine contraction is currently judged by obstetricians, who manually and subjectively evaluate uterine contraction according to uterine hardness. Therefore, uterine atony remains a clinical diagnosis without a universal definition. What do the results of this study add? The present study investigated the use of a tissue hardness metre to quantify uterine contractions during CS with a view to its application for obstetric bleeding management. The hardness metre was able to quantify the degree of uterine contraction perceived by obstetricians. Quantifying uterine hardness during CS correlates with the amount of intra-operative bleeding and is useful for early recognition of massive haemorrhage. What are the implications of these findings for clinical practice and/or further research? To improve the management of atonic PPH and avoid serious complications, the tissue hardness metre should be considered as a potential clinical tool during CS.
Adaption Resizing Communication Buffer to Maximize Lifetime and Reduce Delay for WVSNs

Due to battery-powered wireless video sensor networks (WVSNs) takes on a high video data volume, it becomes a crucial issue to reduce energy consumption to maximize lifetime. At the same time, WVSNs are often applied to important situations for real-time and semi-real-time monitoring, thus ensuring the rapid transmission of these perceived data to sink is another critical issue. In static random-access memory (SRAM) communication buffer-based WVSN node, the radio is turned off during the data buffer-filling period as well as idle period. Because each radio transition contains the additional energy consumed by invalid packet header information and communication connection establishment, and the radio ON/OFF transition incurs extra circuit energy consumption. Therefore, from the perspective of saving energy, we need to reduce the ON/OFF transition frequency, which requires a large-sized buffer. However, the large size of SRAM buffer results in more energy consumption because SRAM energy consumption is proportional to the memory size. More importantly, the large ON/OFF transition frequency will lead to a large data transmission delay, which is harmful to applications. In this paper, an adaption resizing communication buffer (ARCB) scheme is proposed to maximize lifetime and reduce delay for WVSNs. In the ARCB scheme, the buffer size takes the minimum energy consumption optimization value in hotspot areas to maximize lifetime and takes a value smaller than the optimized value in non-hotspot areas to reduce delay. Although this consumes more energy for communication, since nodes in the non-hotspot areas have energy surpluses, it will not affect the lifetime. As a result, ARCB scheme can simultaneously increase the lifetime and reduce the delay in WVSNs. The effectiveness of the ARCB scheme is verified by theoretical analysis. The results show that the proposed ARCB scheme reduces the delay by 27.9%, and increases the effective utilization of energy by 24.1% under the condition that its lifetime is no less than previous schemes.
Analysis of States' Barriers to and Progress Toward Implementation of Health and Safety Policies for Secondary School Athletics.

CONTEXT Implementation of health and safety best practices for the leading causes of sudden death and catastrophic injury has been shown to mitigate risk. However, to our knowledge, no authors have examined progress toward health and safety policy implementation at the state level. OBJECTIVE To investigate the progress made by state secondary school leaders in developing and implementing health and safety policies (ie, exertional heat stroke, sudden cardiac arrest, concussion, emergency action plans) and to explore perceived barriers to and strategies for implementation. DESIGN Mixed-methods study. SETTING State high school athletics associations and sports medicine advisory committees. PATIENTS OR OTHER PARTICIPANTS Collaborative Solutions for Safety in Sport meeting attendees participated in this study. Thirty-five state leaders (current role experience = 8 ± 6 years) completed the survey. Ten of the 35 participated in follow-up interviews. DATA COLLECTION AND ANALYSIS A survey assessing progress on health and safety policy implementation was administered. Respondents indicated whether their state had implemented a policy, made progress without implementation, or made no progress. We conducted follow-up telephone interviews so they could expand on the survey responses. The data were analyzed using descriptive statistics and the general inductive approach. RESULTS A total of 89% of respondents reported their states made progress on or implemented health and safety policies during the 2015-2016 academic year. Barriers to policy implementation included cost, a lack of understanding regarding policies versus recommendations, the content and value of policy change, and a false sense of security. Strategies for implementation included varying approaches to change, education of all constituents, and collaborative relationships among key stakeholders. CONCLUSIONS Although a majority of respondents reported progress in implementing health and safety policies in their states, perceived barriers pointed to the need for the continued education of state leaders in charge of developing and implementing health and safety policies. Despite these barriers, collaboration among key stakeholders is crucial to successful implementation of best-practice policies in secondary school athletics.
Validation of the Spanish Version of the Beginning Breastfeeding Survey-Cumulative: A Follow-up Study

Background: The Beginning Breastfeeding Survey-Cumulative (BBSC) is an instrument that assesses the overall maternal perception of breastfeeding effectiveness during the early postpartum period. Research aims: The aims of this study were to adapt and validate a Spanish version of the BBSC and provide new evidence regarding its validity. Methods: A standard forward and back-translation process was used to obtain the Spanish version of the questionnaire (BBSC-E). A sample of 793 breastfeeding mothers was used. Data were obtained from clinical records and questionnaires self-administered at discharge and at 1–4 months postpartum. The factorial structure of the BBSC-E was examined with both an exploratory and confirmatory approach. Internal consistency, comparisons between known groups, and correlations with other variables were also assessed, and receiver operating characteristics (ROC) curves were used to determine its predictive validity. Results: Analysis revealed a two-dimensional structure, with infant and maternal subscales, and adequate fit statistics. The Root Mean Squared Error of Approximation (RMSEA) was . 067. The Cronbach’s α of the overall scale was . 91. There were statistically significant associations between the BBSC-E and (1) previous breastfeeding experience, early skin-to-skin contact, exclusive breastfeeding, breastfeeding difficulty and self-efficacy, and infant weight loss during hospitalization and (2) at 1–4 months postpartum, with the breastfeeding status, the intensity of breastfeeding problems, and satisfaction with breastfeeding. The total BBSC-E area under the ROC curve for any breastfeeding at 60 days postpartum was . 73, and a score of 88 was the most discriminative cut-off point for maximum performance. Conclusion: The BBSC-E is a reliable and valid instrument for measuring breastfeeding effectiveness during early postpartum.
CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties

Melanocyte stem cells (McSCs) are the undifferentiated melanocytic cells of the mammalian hair follicle (HF) responsible for recurrent generation of a large number of differentiated melanocytes during each HF cycle. HF McSCs reside in both the CD34+ bulge/lower permanent portion (LPP) and the CD34- secondary hair germ (SHG) regions of the HF during telogen. Using Dct-H2BGFP mice, we separate bulge/LPP and SHG McSCs using FACS with GFP and anti-CD34 to show that these two subsets of McSCs are functionally distinct. Genome-wide expression profiling results support the distinct nature of these populations, with CD34- McSCs exhibiting higher expression of melanocyte differentiation genes and with CD34+ McSCs demonstrating a profile more consistent with a neural crest stem cell. In culture and in vivo, CD34- McSCs regenerate pigmentation more efficiently whereas CD34+ McSCs selectively exhibit the ability to myelinate neurons. CD34+ McSCs, and their counterparts in human skin, may be useful for myelinating neurons in vivo, leading to new therapeutic opportunities for demyelinating diseases and traumatic nerve injury.
Calcined Oyster Shell Powder as an Expansive Additive in Cement Mortar

The present study prepared calcined oyster shell powder having chemical composition and crystal structure of calcium oxide and lime, respectively, and investigated the fresh and hardened properties of cement mortar incorporating calcined oyster shell powder as an additive. The test results indicated that the hydration of calcined oyster shell powder promoted the additional formation of Ca(OH)2 at the initial reaction stage, thereby increasing the heat of hydration. In particular, the volumetric increase of calcined oyster shell powder during hydration compensated the autogenous shrinkage of mortar at early ages, ultimately leading to a clear difference in the shrinkage values at final readings. However, an excessive incorporation of calcined oyster shell powder affected the rate of C–S–H formation in the acceleratory period of hydration, resulting in a decrease in the compressive strength development. Meanwhile, the degree of flow loss was inconsequential and rapid flow loss was not observed in the specimens with calcined oyster shell powder. Therefore, considering the fresh and hardened properties of cement mortar, the incorporation of calcined oyster shell powder of approximately 3% by weight of cement is recommended to enhance the properties of cement mortar in terms of compressive strength and autogenous shrinkage.
Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins

The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes (Vaa), in particular, is, medically, one of the most relevant snakes in Europe. The local and systemic clinical manifestations of poisoning by the venom of this snake are the result of the pathophysiological effects inflicted by enzymatic and nonenzymatic venom components acting, most prominently, on the blood, cardiovascular, and nerve systems. This venom is a very complex mixture of pharmacologically active proteins and peptides. To help improve the current antivenom therapy toward higher specificity and efficiency and to assist drug discovery, we have constructed, by combining transcriptomic and proteomic analyses, the most comprehensive library yet of the Vaa venom proteins and peptides. Sequence analysis of the venom gland cDNA library has revealed the presence of messages encoding 12 types of polypeptide precursors. The most abundant are those for metalloproteinase inhibitors (MPis), bradykinin-potentiating peptides (BPPs), and natriuretic peptides (NPs) (all three on a single precursor), snake C-type lectin-like proteins (snaclecs), serine proteases (SVSPs), P-II and P-III metalloproteinases (SVMPs), secreted phospholipases A2 (sPLA2s), and disintegrins (Dis). These constitute >88% of the venom transcriptome. At the protein level, 57 venom proteins belonging to 16 different protein families have been identified and, with SVSPs, sPLA2s, snaclecs, and SVMPs, comprise ∼80% of all venom proteins. Peptides detected in the venom include NPs, BPPs, and inhibitors of SVSPs and SVMPs. Of particular interest, a transcript coding for a protein similar to P-III SVMPs but lacking the MP domain was also found at the protein level in the venom. The existence of such proteins, also supported by finding similar venom gland transcripts in related snake species, has been demonstrated for the first time, justifying the proposal of a new P-IIIe subclass of ancestral SVMP precursor-derived proteins.
What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation.

Deciding what to do and when to move is vital to our survival. Clinical and fundamental studies have identified basal ganglia circuits as critical for this process. The main input nucleus of the basal ganglia, the striatum, receives inputs from frontal, sensory, and motor cortices and interconnected thalamic areas that provide information about potential goals, context, and actions and directly or indirectly modulates basal ganglia outputs. The striatum also receives dopaminergic inputs that can signal reward prediction errors and also behavioral transitions and movement initiation. Here we review studies and models of how direct and indirect pathways can modulate basal ganglia outputs to facilitate movement initiation, and we discuss the role of cortical and dopaminergic inputs to the striatum in determining what to do and if and when to do it. Complex but exciting scenarios emerge that shed new light on how basal ganglia circuits modulate self-paced movement initiation. Expected final online publication date for the Annual Review of Neuroscience Volume 42 is July 8, 2019 Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study

Purpose: Exercise after breast cancer diagnosis is associated with lower cancer-specific mortality, but the biological mechanisms through which exercise impacts breast cancer are not fully understood. The Pre-Operative Health and Body (PreHAB) Study was a randomized window-of-opportunity trial designed to test the impact of exercise on Ki-67, gene expression, and other biomarkers in women with breast cancer. Experimental Design: Inactive women with newly diagnosed breast cancer were randomized to an exercise intervention or mind–body control group, and participated in the study between enrollment and surgery (mean 29.3 days). Tumor and serum were collected at baseline and surgery. Results: Forty-nine women were randomized (27 exercise, 22 control). At baseline, mean age was 52.6, body mass index was 30.2 kg/m2, and exercise was 49 minutes/week. Exercise participants significantly increased exercise versus controls (203 vs. 23 minutes/week, P < 0.0001). There were no differences in changes of expression of Ki-67, insulin receptor, and cleaved caspase-3 in exercise participants versus controls. KEGG pathway analysis demonstrated significant upregulation of 18 unique pathways between the baseline biopsy and surgical excision in exercise participants and none in control participants (q < 0.1). Top-ranked pathways included several implicated in immunity and inflammation. Exploratory analysis of tumor immune infiltrates demonstrated a trend toward a decrease in FOXP3+ cells in exercise versus control participants over the intervention period (P = 0.08). Conclusions: A window-of-opportunity exercise intervention did not impact proliferation but led to alterations in gene expression in breast tumors, suggesting that exercise may have a direct effect on breast cancer. See related commentary by Koelwyn and Jones, p. 5179
Common variants of the oxytocin receptor gene do not predict the positive mood benefits of prosocial spending.

Who benefits most from helping others? Previous research suggests that common polymorphisms of the oxytocin receptor gene (OXTR) predict whether people behave generously and experience increases in positive mood in response to socially focused experiences in daily life. Building on these findings, we conducted an experiment with a large, ethnically homogenous sample (N = 437) to examine whether individual differences in three frequently studied single nucleotide polymorphisms of OXTR (rs53576, rs2268498, rs2254298) also predict differences in the positive mood benefits of financial generosity. Consistent with past research, participants who were randomly assigned to purchase items for others (vs. themselves) reported greater positive affect. Contrary to predictions, using Bayesian statistics, we found conclusive evidence that the benefits of generosity were not moderated by individual differences in OXTR single nucleotide polymorphisms. The current work highlights the importance of publishing null results to build cumulative knowledge linking neurobiological factors to positive emotional experiences. (PsycINFO Database Record (c) 2019 APA, all rights reserved).