Miracle-dz/UniFAR-FTUs huggingface dataset:
Examining the entire delayed respiratory syncytial virus season in Western Australia

REFERENCES 1 Richter LM, Daelmans B, Lombardi J, et al. Investing in the foundation of sustainable development: pathways to scale up for early childhood development. Lancet 2017;389:103–18. 2 Proulx K, LenziWeisbecker R, Rachel R, et al. Responsive caregiving, opportunities for early learning, and children’s safety and security during COVID19: A rapid review. medRxiv 2021. 3 Chan M, Lake A, Hansen K. The early years: silent emergency or unique opportunity? The Lancet 2017;389:11–13. 4 Villar J, Fernandes M, Purwar M, et al. Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nat Commun 2019;10:1–0.
Unified model involving genomics, magnetic resonance imaging and prostate‐specific antigen density outperforms individual co‐variables at predicting biopsy upgrading in patients on active surveillance for low risk prostate cancer

Active surveillance (AS) is the reference standard treatment for the management of low risk prostate cancer (PCa). Accurate assessment of tumor aggressiveness guides recruitment to AS programs to avoid conservative treatment of intermediate and higher risk patients. Nevertheless, underestimating the disease risk may occur in some patients recruited, with biopsy upgrading and the concomitant potential for delayed treatment.
Diagnostic performance of MRI and endoscopy for assessing complete response in rectal cancer after neoadjuvant chemoradiotherapy: a systematic review of the literature

Background The diagnostic performance of magnetic resonance imaging (MRI) modalities and/or endoscopy for assessing complete response in rectal cancer after neoadjuvant chemoradiotherapy (nCRT) is unclear. Purpose To summarize existing evidence on the diagnostic performance of diffusion-weighted MRI, perfusion-weighted MRI, T2-weighted MR tumor regression grade, and/or endoscopy for assessing complete tumor response after nCRT. Material and Methods MEDLINE and Embase databases were searched. The PRISMA guidelines were followed. Sensitivity, specificity, negative predictive, and positive predictive values were retrieved from included studies. Results In total, 81 studies were eligible for inclusion. Evidence suggests that combined use of MRI and endoscopy tends to improve the diagnostic performance compared to single imaging modality. The positive predictive value of a complete response varies substantially between studies. There is considerable heterogeneity between studies. Conclusion Combined re-staging tends to improve diagnostic performance compared to single imaging modality, but the vast majority of studies fail to offer true clinical value due to the study heterogeneity.
Improved Response of Uni-Traveling-Carrier Photodiodes by Carrier Injection

We have studied the ultrafast response of uni-traveling-carrier photodiodes with photo-absorption layer doping levels from 2.5 ×1017 to 2.5 ×1018 cm-3. It is found that 3-dB band width increases with the output voltage in the low output region. This enhancement is more prominent for a lower doping level in the photo-absorption layer. From the analysis of the carrier transport in the photo-absorption layer, we attribute the observed enhanced bandwidth as a result of the self-induced electric field associated with carrier injection.
Cerebrospinal fluid flow cytometry and risk of central nervous system relapse after hyperCVAD in adults with acute lymphoblastic leukemia

Potential involvement of the central nervous system (CNS) by acute lymphoblastic leukemia is typically evaluated by a conventional cytospin (CC) of cerebrospinal fluid (CSF). Multiparameter flow cytometry (MFC) is generally more sensitive and specific than morphology, but data to guide its use versus CC are limited.
Availability, healthiness, and price of packaged and unpackaged foods in India: A cross-sectional study

Background: Vulnerable populations are the most prone to diet-related disease. The availability, healthiness, and price of foods have established associations with diet-related disease in communities. However, data describing this in India are sparse, particularly in urban slums and rural areas. Aim: To quantify and compare availability, healthiness, and price of packaged and unpackaged foods and beverages in India, and to identify opportunities to improve diets and health of vulnerable populations. Methods: Nutrition data and price were collected on foods and beverages available at 44 stores in urban, urban slum, and rural areas in four states in India between May and August 2018. Healthiness was assessed using the Australasian Health Star Rating system and product retail prices were examined. Comparisons in the findings were made across state, community area type, and adherence to current and draft Indian food labeling regulations. Results: Packaged foods and beverages (n = 1443, 89%) were more prevalent than unpackaged (n = 172, 11%). Unpackaged products were healthier than packaged (mean Health Star Rating = 3.5 vs 2.0; p < 0.001) and lower in price (median price per 100 g/ml: 13.42 Indian rupees vs 25.70 Indian rupees; p < 0.001), a pattern observed across most community area types and states. 96% of packaged products were compliant with current Indian labeling regulations but only 23% were compliant with proposed labeling regulations. Conclusions: Unpackaged products were on average much healthier and lower in price than packaged foods and beverages. Food policies that support greater availability, accessibility and consumption of unpackaged foods, while limiting consumption of packaged foods, have enormous potential for sustaining the health of the Indian population.
Systematic validation of structural brain networks in cerebral small vessel disease

Cerebral small vessel disease (SVD) is considered a disconnection syndrome, which can be quantified using structural brain network analysis obtained from diffusion MRI. Network analysis is a demanding analysis approach and the added benefit over simpler diffusion MRI analysis is largely unexplored in SVD. In this pre-registered study, we assessed the clinical and technical validity of network analysis in two non-overlapping samples of SVD patients from the RUN DMC study (n = 52 for exploration and longitudinal analysis and n = 105 for validation). We compared two connectome pipelines utilizing single-shell or multi-shell diffusion MRI, while also systematically comparing different node and edge definitions. For clinical validation, we assessed the added benefit of network analysis in explaining processing speed and in detecting short-term disease progression. For technical validation, we determined test-retest repeatability. Our findings in clinical validation show that structural brain networks provide only a small added benefit over simpler global white matter diffusion metrics and do not capture short-term disease progression. Test-retest reliability was excellent for most brain networks. Our findings question the added value of brain network analysis in clinical applications in SVD and highlight the utility of simpler diffusion MRI based markers.
Epidemiological Trends of Breast Cancer in Southern Ethiopia: A Seven-Year Retrospective Review

Introduction African women are affected by cancer at an early age of their productivity. However, the exact prevalence and incidence of cancer, including breast cancer is not known in most sub-Saharan African countries, including Ethiopia because of lack of well-established cancer registry. This study aims to assess the epidemiology of breast cancer at Hawassa University Comprehensive Specialized Hospital (HUCSH), the biggest referral hospital with cancer treatment center serving the southern part of the country. Methods Retrospective review of charts of all patients with a diagnosis of breast cancer between 2013 and 2019 at HUCSH was conducted. A standardized questionnaire was used to collect relevant data that include sociodemographic, symptoms, type of diagnosis, treatment, and outcomes. Data were entered using epidata version 3.1 and analyzed using MS Excel and SPSS version 20. Results Five hundred fifty-nine (18.6%) breast cancer cases were retrieved in 7 years between 2013 and 2019. Of this, 548 (98%) were women. The median ages of the patents were 38 years. Invasive ductal carcinoma was the leading 309 (55.3%) histologic type followed by 185 (33.1%) lobular carcinoma. One hundred seventy-seven (31.7%) were moderately differentiated and 155 (27.7%) were poorly differentiated. Three hundred seventy-two (66.5%) were advanced breast cancer (Stages III and IV). Trends of breast cancer showed the case load is continuously increasing except with a slight reduction of cases in between 2015 and 2016. The majority were advanced breast cancer occurring at an early age by the time diagnosis made. Invasive ductal carcinomas were the predominant one. The trend also showed a continuous increment of cancer case load. Therefore, cancer registration center establishment, community awareness creation, and intensive early detection strategy are mandatory.
Evaluation of Various Technologies for Wave Energy Conversion in the Portuguese Nearshore

The objective of the present work is to perform an evaluation of the performance provided by various technologies for wave energy conversion in the Portuguese continental coastal environment. The wave climate in the target area is first analyzed using the results from three years of simulations with a wave prediction system based on numerical models. Based on the above data, diagrams for the bivariate distributions of the sea states occurrences, defined by the significant wave height and the energy period, are designed for both winters and whole years. On this basis, the output of five different technologies for the conversion of wave energy is assessed in some relevant locations from the Portuguese nearshore. According to the results obtained, the Portuguese continental coastal environment appears to be appropriate for the wave energy extraction. At the same time, the present work shows that the output of the wave energy conversion devices does not depend only on the average wave energy but is also dependent on the distribution of the wave energy among the sea states of different periods. For this reason, a good agreement between the characteristics of the power matrices of the wave energy converters operating in a certain place and the diagrams for the bivariate distributions of the sea states occurrences corresponding to the considered location represents a key issue in selecting the most appropriate technology for wave energy conversion.
Natural killer cell deficiency experiences higher risk of sepsis after critical intracerebral hemorrhage

Background: Lymphopenia is common in intracerebral hemorrhage (ICH) and may predispose to severe infections such as sepsis. However, what specific kind of lymphocytes subsets decreases is still unclear. We investigated the impact of lymphocytes subsets on post-critical ICH infections and mortality. Methods: Consecutive ICH patients (admitted to a single center between January 2017 and January 2018) were prospectively assessed to evaluate the following main parameters: peripheral blood lymphocytes, infections, and clinical scores. Predicting factors of sepsis were measured using multivariate Logistic regressions analysis. A Kaplan–Meier survival curve was performed to compare the mortality between septic and nonseptic patients. Survival status was evaluated by multivariate Cox regression analysis. Results: In total, 112 critical ICH cases were enrolled including 29 septic patients. Total counts of lymphocytes decreased accordingly with reduced lymphocyte subsets, especially natural killer (NK) cells and CD8+T lymphocytes after ICH. Septic patients had a higher incidence of pneumonia, a longer length of stay, higher 90-day mortality, and worse long-term outcomes. Multivariate Logistic regression analysis showed venous catheterization, high APACHE-II score (>15), low GCS score (3–5), and NK cells percentages on admission were independently associated with ensuing sepsis. After sepsis, the percentages of CD4+T and NK cells percentages decreased, CD8+T cells increased followed by a significantly decreased CD4/CD8 ratio. Bloodstream infection alone directly affected the survival status of patients with sepsis. Conclusions: Critical ICH patients underwent immune dysfunction and NK cells deficiency could favor nosocomial threatening sepsis after ICH.
A qualitative analysis of the perceived determinants of success in elite esports athletes

ABSTRACT The current study aimed to qualitatively investigate the perceived determinants of success in professional esports athletes. Guided by the bioecological model (Bronfenbrenner & Morris, 2006), thematic analysis was used to explore elite esports athletes’ perceptions of success determinants. Semi-structured interviews were conducted with seven elite esports athletes. The interviews were used to investigate players’ psychology when playing well, training in elite esports, and working in esports teams. Deductive and inductive analyses were conducted to capture the core themes of success in esports within the bioecological model. When playing well, elite esports athletes experienced high levels of confidence, uninterrupted focus, and flow states. Elite esport athletes use mental strategies to help regulate their emotions and remain mindful in the presence of “tilt”. Furthermore, breathing techniques and tactical breaks were used when players felt nervous or when trying to “reset” from a stressful situation. When working in elite esport teams, players reported using strategies to improve team cohesion and that the biggest challenge was interpersonal disagreements. The results contribute to the growing body of literature highlighting the psychological similarities between elite esports and traditional sports athletes and serve as an index for future research into high-performance in esports.
Track-structure modes in particle and heavy ion transport code system (PHITS): application to radiobiological research

Abstract Purpose In radiation physics, Monte Carlo radiation transport simulations are powerful tools to evaluate the cellular responses after irradiation. When investigating such radiation-induced biological effects, it is essential to perform track structure simulations by explicitly considering each atomic interaction in liquid water at the sub-cellular and DNA scales. The Particle and Heavy-Ion Transport code System (PHITS) is a Monte Carlo code which enables to calculate track structure at DNA scale by employing the track-structure modes for electrons, protons and carbon ions. In this paper, we review the recent development status and future prospects of the track-structure modes in the PHITS code. Conclusions To date, the physical features of these modes have been verified using the available experimental data and Monte Carlo simulation results reported in literature. These track-structure modes can be used for calculating microdosimetric distributions to estimate cell survival and for estimating initial DNA damage yields. The use of PHITS track-structure mode is expected not only to clarify the underlying mechanisms of radiation effects but also to predict curative effects in radiation therapy. The results of PHITS simulations coupled with biophysical models will contribute to the radiobiological studies by precisely predicting radiation-induced biological effects based on the Monte Carlo approach.
The Oblique Effect in the Perception of the Direction Between Two Points of Vibration on the Back

Vibrations on the back of a person can convey information about direction through sequentially switching on two vibration motors. For perception of direction the oblique effect can occur, meaning that perception of cardinal directions is more precise than perception of oblique directions. We investigated the role of the positioning of the vibrations with respect to the spine. In the first condition all vibration motors were placed in a circle around the spine (‘Circle’ condition) and direction was conveyed by switching on vibration motors on opposite sides of the circle. In the second condition the vibrations were placed in two semi-circles of which the centers were on the left and right sides of the back (‘Semi-circle’ condition). We found that participants showed larger deviations as well as a larger spread for oblique directions than for cardinal directions in both conditions. This indicates that the oblique effect occurred. Therefore, the oblique effect can occur irregardless of the positioning of the vibration motors with respect to the spine. Both deviations and spread were larger in the ‘Semi-circle’ condition than in the ‘Circle’ condition suggesting an advantage for centering motors around the spine, although this might have been influenced by the distance between vibrations.
Preparation of Graphene and γ-Fe2O3 Doped Titanium Dioxide and its Photocatalytic Properties

In this paper graphene is used to improve absorption rate of nano-titanium dioxide under visible light, meanwhile titanium dioxide is doped with superparamagnetism nano-powder of γ-Fe2O3 to modify the recovery of the photocatalyst. Gradually the increasing content of grapheme promotes the removal efficiency and correspondingly. Excitation condition is reduced and the photocatalysis property under visible light is improved and recycle rate of the titanium dioxide is effective promoted after the dispose. The effect of photocatalytic degradation of methylene blue is used to evaluate the photocatalytic activity. The methylene blue degradation rate raised from 53.4% to 85.9% with the increasing graphene load from 5% to 20% under visible light. The degradation efficiency of methylene blue decreased to 15% without the graphene load. The recovery rate of the photocatalyst can achieve 95% above. Graphene oxide works as the electron acceptor and photosensitizer to efficiently enhance the dye photodecomposition.
Can COVID‐19 cause atypical forms of pityriasis rosea refractory to conventional therapies?

We read with great interest the article by Veraldi et Al. on the relationship between Pityriasis Rosea (PR) and Covid 19 infection (1). In response to the above mentioned article we would like to share our experience on a case of Pityriasis Rosea diagnosed after Covid 19 infection with atypical clinical presentation and low responsiveness to conventional treatments. Pityriasis rosea of Gibert (PR) is an erythematous-papulosquamous dermatosis that frequently occurs in young adults; it is a common self-limiting rash,with a typical duration of 6-8 weeks (2). It usually starts with a herald patch on the trunk and progresses along the langer lines to a generalized rash over the trunk and limbs, giving it a "Christmas tree" appearance. The diagnosis is usually based on clinical and physical examinations findings (3). The etiopathogenesis of PR is still unknown, but it may be associated with upper respiratory tract infections. (3) Particularly, a viral etiology was proposed since intranuclear and intracytoplasmic virus-like particles were observed through microscopy; the most common viruses linked to PR are human herpesvirus-6 and -7 (HHV-6 and -7) (3-4). It has been recently proposed that a new viral trigger of PR may be the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (1,4). Indeed, several patients affected by infection due to COVID 19 presented an atypical PR (5). We herein report our experience about the relationship between PR and Covid 19. This article is protected by copyright. All rights reserved.
Bidirectional associations between cognitive functions and walking performance among middle-aged women

Supplemental Digital Content is available in the text Abstract Objective: This study investigated whether (1) cognitive functions change after the transition from the perimenopausal to the postmenopausal stage, (2) cognitive functions and walking are associated in middle-aged women, and (3) cognitive functions assessed in perimenopause are associated with walking after reaching the postmenopause or vice versa. Methods: In total, 342 women, categorized as early (n = 158) or late perimenopausal (n = 184), were included in the study and followed up until postmenopausal. Psychomotor speed, executive functions related to set-shifting and updating, working memory, and visual memory were assessed. Walking was assessed with walking speed, walking distance, and dual-task cost in walking speed. Data was analyzed using the paired-samples t test, Wilcoxon signed rank test, multiple linear regression analysis, and structural equation modeling. Results: We found small but significant improvements in psychomotor speed (P = 0.01) and working memory (P < 0.001) among early perimenopausal and in psychomotor speed (P = 0.001), set-shifting (P = 0.02), visual memory (P = 0.002), and working memory (P < 0.001) among late perimenopausal women after the transition from peri- to postmenopause. Walking speed (β = 0.264, P = 0.001) and dual-task cost (β = 0.160, P = 0.03) were associated with updating, and walking distance was associated with updating and set-shifting (β = 0.198, P = 0.02, β=−0.178 P = 0.04 respectively) among the late perimenopausal women. We found no longitudinal associations between cognitive functions and walking. Conclusion: Cognitive performance remained unchanged or improved after reaching postmenopause. Cognitive functions and walking were associated during the late perimenopause, but the association depended on the cognitive process and nature of the physical task. Cognitive performance was not associated with walking after reaching postmenopause or vice versa.
Prevalence and Risk Factors of Dry Eye Symptoms after Successful Dacryocystorhinostomy for Patients with Lacrimal Passage Obstruction

Purpose To investigate the prevalence of dry eye symptoms after successful dacryocystorhinostomy and explore the potential risk factors. Methods This cross-sectional study included 565 patients with lacrimal passage obstruction (LPO) who underwent external dacryocystorhinostomy. Ocular Surface Disease Index (OSDI) total score of 13 or more was regarded as presence of dry eye symptoms. OSDI total score greater than 22 combined with self-reported dry eye was defined as symptomatic dry eye. Logistic regression and linear regression were used to examine the associations between OSDI scores and its potentially predictive factors. Results Of the 565 patients, 344 completed the questionnaire, among which 101(29.4%) patients presented with dry eye symptoms, including 53(15.4%) mild, 14(4.1%) moderate and 34(9.9%) severe, and 48(14.0%) patients can be defined as symptomatic dry eye. Univariate logistic regression revealed that age, educational levels, income levels, and hypertension were significantly correlated with the presence of dry eye symptoms (P < 0.05). After multivariate adjustment, lower income levels were found significantly associated with dry eye symptoms (P < 0.05). Univariate linear regression demonstrated that age, lower educational levels, surgery history, and hypertension were significantly associated with OSDI total score (P = 0.037, 0.012, 0.022, 0.029 respectively). Multivariate stepwise linear regression manifested that educational levels and the surgery history influenced the OSDI total score mostly (P = 0.021, 0.036 respectively). Conclusions Dry eye problem of LPO patients after successful dacryocystorhinostomy cannot be ignored. In the preoperative evaluation, we should pay special attention to the elderly patients with lower educational levels, lower income levels or systemic diseases.