Miracle-dz/UniFAR-FTUs huggingface dataset:
Interrater Agreement of an Arthroscopic Anterior Cruciate Ligament Tear Classification System

Background: Anterior cruciate ligament (ACL) rupture is the most common ligament injury treated surgically by orthopaedic surgeons. The gold standard for the treatment of the majority of primary ACL tears is ACL reconstruction. However, novel methods of repair, such as bridge-enhanced ACL repair (BEAR), are currently being investigated as alternatives to reconstruction. To assess patients for midsubstance repair suitability, clarify the prognostic implications of injury location and damage, and evaluate the results of a repair technique, it is important to have a baseline classification system or grading scale that is reproducible across surgeons, particularly for multicenter collaboration. Currently, no such system or scale exists. Purpose: To develop an arthroscopic ACL tear classification system and to evaluate its interobserver reliability. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: Eleven fellowship-trained orthopaedic surgeon investigators reviewed 75 video clips containing arthroscopic evaluation of a torn ACL and then completed the 6-question ACL Pathology Evaluation Form. Agreement statistics including exact agreement, Fleiss κ, Gwet agreement coefficient 1 (AC1), and Gwet AC2 were then calculated to assess interobserver reliability. Results: In aggregate, the multiple assessments of observer reproducibility revealed that surgeon participants in this study, when evaluating the same injury, agreed roughly 80% of the time on whether (1) at least 50% of the tibial footprint remained, (2) the remaining tibial stump was ≥10 mm, and (3) the injury was therefore reparable using the BEAR procedure. Participants also agreed roughly 60% of the time on exactly how many suturable bundles were available. These characteristics are believed to be most important, among those studied, in determining whether a torn ACL is amenable to midsubstance repair. Conclusion: This study is the first of its kind to demonstrate the interobserver reliability of arthroscopic classification of ACL tears. We have demonstrated that this classification system, though not ideally reproducible, is reliable enough across surgeons at multiple institutions for use in multicenter studies. Registration: NCT03776162 (ClinicalTrials.gov identifier).
Epidemiology of human leptospirosis in Saint Lucia, 2010–2017

ABSTRACT Objective. To describe the epidemiology of human leptospirosis cases in Saint Lucia from 2010 to 2017 and determine whether there was a relationship between cases and rainfall and temperature. Methods. A retrospective analytical study was undertaken to describe the seasonal patterns of human leptospirosis cases reported to the Ministry of Health of Saint Lucia between 2010 and 2017. Confirmed cases of leptospirosis were analyzed according to age, sex, seasonality, and geographical distribution. Disease incidence was calculated and the association of cases with geographical distribution, rainfall, and temperature was investigated. Results. A total of 353 leptospirosis cases were reported between 2010 and 2017 and of these, 145 (40.6%) were laboratory confirmed. Cases were aged 7 to 73 years (mean 34 years; median 30 years) with a male to female ratio of 4.2:1. Six deaths were reported during the period, with an overall case fatality rate of 4.1%. There was no relationship between location (district) and incidence of leptospirosis in Saint Lucia. There was a weak correlation between rainfall and leptospirosis cases during the 8-year period (rs = 0.25, p = 0.015) but the correlation between cases and seasons was not statistically significant (dry season rs = 0.13, p= 0.42; wet season rs = 0.23, p = 0.08). There was no correlation between leptospirosis cases and temperature (rs = 0.07, p= 0.49). Conclusions. Leptospirosis has a seasonal distribution in Saint Lucia, with outbreaks during periods following increased rainfall and flooding, such as in the aftermath of tropical storms and hurricanes. Saint Lucia and other Caribbean countries should enhance surveillance for leptospirosis given the likelihood of increased flooding following frequent and intense rainfall due to climate change.
Autologous Fat Grafting Promotes Macrophage Infiltration to Increase Secretion of Growth Factors and Revascularization, Thereby Treating Diabetic Rat Skin Defect

Background Diabetic skin defect is difficult to manage in surgical clinics, and there is still lack of effective treatments for diabetic skin defects. Currently, autologous fat grafting (AFG) is promising in the field of reconstructive surgery, while macrophage infiltration in autologous adipose tissue is considered vital for tissue regeneration. But AFG is rarely applied to the treatment of diabetic skin defects, and whether macrophage infiltration assists AFG to promote wound healing is still unknown. Methods Full-thickness skin defect diabetic rats were divided into 3 groups: control group, autologous fat grafting (AFG) group and AFG with macrophage depletion (AFG+MD) group. We examined the amount of macrophages in the wounds bed and the expression level of inflammatory factors IL-10, IL-6, TNF-α, and also growth factors PDGF-β, TGF-β, IGF-1 at the same time. The content of collagen-I and α-smooth muscle actin protein in the wounds were determined by Western blot analysis. Finally, the healing of the wounds was evaluated. Results The AFG group showing more rapid healing, secreting more growth factors and more obvious vascularization in the healing process, compared with the control group. But, the secretion of growth factors and the construction of extracellular matrix (ECM) in the wounds were limited when macrophages were depleted after AFG. Conclusion AFG promotes the infiltration of macrophages to improve the healing environment of diabetic wounds by increasing the secretion of growth factors and revascularization, which provides a potential method for the treatment of diabetic skin defects.
Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4

ABSTRACT The cyclin-dependent kinase inhibitor p27Kip1 is a tumor suppressor whose intrinsic activity in cancer cells correlates with tumor aggressiveness, invasiveness, and impaired tumor cell differentiation. Here we explore whether p27Kip1 indirectly influences tumor progression by restricting expansion and survival of effector memory T cell (TEM) populations in a preclinical model of spontaneous colitis-associated colorectal cancer (CAC). We show mRNA and protein expression of p27Kip1 to be significantly decreased in the colons of mice with a T cell-restricted deletion of the TGF-β intermediate, SMAD4 (Smad4TKO). Loss of p27Kip1 expression in T cells correlates with the onset of spontaneous CAC in Smad4TKO mice by 8 months of age. This phenotype is greatly accelerated by the introduction of a germline deletion of CDKN1b (the gene encoding p27Kip1) in Smad4TKO mice (Smad4TKO/p27Kip1-/-, DKO). DKO mice display colon carcinoma by 3 months of age and increased mortality compared to Smad4TKO. Importantly, the phenotype in DKO mice is associated with a significant increase in the frequency of effector CD4 T cells expressing abundant IFN-γ and with a concomitant decrease in Foxp3+ regulatory T cells, both in the intestinal mucosa and in the periphery. In addition, induction of inflammatory mediators (IFN-γ, TNF-γ, IL-6, IL-1β, iNOS) and activation of Stat1, Stat3, and IκB is also observed in the colon as early as 1–2 months of age. Our data suggest that genomic alterations known to influence p27Kip1 abundance in gastrointestinal cancers may indirectly promote epithelial malignancy by augmenting the production of inflammatory mediators from a spontaneously expanding pool of TEM cells.
Self-care practice and associated factors among hypertensive patients in public health facilities in Harar Town, Eastern Ethiopia: A cross-sectional study

Background: Self-care practice is the activity that a hypertensive patient undertakes intending to improve their health. Poor self-care practice leads to uncontrolled hypertension. Therefore, strategies designed to prevent and control hypertension-related death, disability, and morbidity should consider the level of the patient’s self-care practice and risk factors. This study assessed self-care practice and associated factors among hypertensive patients in public health facilities of Harar Town in eastern Ethiopia. Method: An institution-based cross-sectional study was conducted among 398 randomly selected hypertensive patients from 25 March 2019 to 16 April 2019. Pretested structured questionnaires adapted from validated tools were used to collect data from participants using electronic Open Data Kit software through face-to-face exit interview. Data were analyzed by SPSS version 24. Bivariable and multivariable logistic regression analyses were conducted to identify factors associated with self-care practice. Adjusted odds ratio with 95% confidence interval was used to report association and the significance was declared at p-value < 0.05. Results: Level of good self-care practice was 29.9% (95% confidence interval: 25.3% and 34.7%). Age ⩾ 60 years (adjusted odds ratio = 3.4, 95% confidence interval: 1.2 and 9.3), formal education (adjusted odds ratio = 2.3, 95% confidence interval: 1.3 and 4.2), absence of comorbidities (adjusted odds ratio = 1.8, 95% confidence interval: 1.1 and 3.1), adequate knowledge about hypertension (adjusted odds ratio = 4.7, 95% confidence interval: 2.5 and 8.8), good social support (adjusted odds ratio = 2.7, 95% confidence interval: 1.6 and 4.7), and being khat abstainer (adjusted odds ratio = 1.9, 95% confidence interval: 1.1 and 3.5) were significantly associated with good self-care practice. Conclusion: The prevalence of good self-care practice was low. In this study, good self-care practice was significantly associated with age, formal education, comorbidities, knowledge about hypertension, social support, and current khat chewing condition. Regular check-up and follow-up of patients’ compliance with self-management protocol, and more emphasis should be given to identify factors that potentially impeding patients’ adherence to hypertension self-management protocol.
Mechanical Properties of Nanohybrid Resin Composites Containing Various Mass Fractions of Modified Zirconia Particles

Purpose The aim of this study was to investigate the effect of various mass fractions of 10-methacry-loyloxydecyl dihydrogen phosphate (MDP)-conditioned or unconditioned zirconia nano- or micro-particles with different initiator systems on the mechanical properties of nanohybrid resin composites. Methods Both light-cured (L) and dual-cured (D) resin composites were prepared. When the mass fraction of the nano- or micro-zirconia fillers reached 55 wt%, resin composites were equipped with dual-cured initiator systems. We measured the three-point bending-strength, elastic modulus, Weibull modulus and translucency parameter of the nanohybrid resin composites containing various mass fractions of MDP-conditioned or unconditioned zirconia nano- or micro-particles (0%, 5 wt%, 10 wt%, 20 wt%, 30 wt% and 55 wt%). A Cell Counting Kit (CCK)-8 was used to test the cell cytotoxicity of the experimental resin composites. The zirconia nano- or micro-particles with MDP-conditioning or not were characterized by transmission electron microscopy (TEM), Fourier infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). Results Resin composites containing 5–20 wt% MDP-conditioned or unconditioned nano-zirconia fillers exhibited better three-point bending-strength than the control group without zirconia fillers. Nano- or micro-zirconia fillers decreased the translucence of the nanohybrid resin composites. According to the cytotoxicity classification, all of the nano- or micro-zirconia fillers containing experimental resin composites were considered to have no significant cell cytotoxicity. The FTIR spectra of the conditioned nano- or micro-fillers showed new absorption bands at 1719 cm−1 and 1637 cm−1, indicating the successful combination of MDP and zirconia particles. The XPS analysis measured Zr–O–P peak area on MDP-conditioned nano- and micro-zirconia fillers at 39.91% and 34.89%, respectively. Conclusion Nano-zirconia filler improved the mechanical properties of nanohybrid resin composites, but cannot be the main filler to replace silica filler. The experimental dual-cured composites can be resin cements with better opacity effects and a low viscosity.
Nests in the cities: adaptive and non-adaptive phenotypic plasticity and convergence in an urban bird

Phenotypic plasticity plays a critical role in adaptation to novel environments. Behavioural plasticity enables more rapid responses to unfamiliar conditions than evolution by natural selection. Urban ecosystems are one such novel environment in which behavioural plasticity has been documented. However, whether such plasticity is adaptive, and if plasticity is convergent among urban populations, is poorly understood. We studied the nesting biology of an ‘urban-adapter’ species, the dark-eyed junco (Junco hyemalis), to understand the role of plasticity in adapting to city life. We examined (i) whether novel nesting behaviours are adaptive, (ii) whether pairs modify nest characteristics in response to prior outcomes, and (iii) whether two urban populations exhibit similar nesting behaviour. We monitored 170 junco nests in urban Los Angeles and compared our results with prior research on 579 nests from urban San Diego. We found that nests placed in ecologically novel locations (off-ground and on artificial surfaces) increased fitness, and that pairs practiced informed re-nesting in site selection. The Los Angeles population more frequently nested off-ground than the San Diego population and exhibited a higher success rate. Our findings suggest that plasticity facilitates adaptation to urban environments, and that the drivers behind novel nesting behaviours are complex and multifaceted.
Effectiveness of a web-based computer-tailored intervention promoting physical activity for adults from Quebec City: a randomized controlled trial

ABSTRACT Background The primary objective of this study was to determine the effectiveness of a 3-month web-based computer-tailored intervention on moderate-to-vigorous physical activity (MVPA) in adults. Methods A total of 242 Canadian adults aged between 35 and 70 years were randomized to an experimental group receiving the intervention or a waiting list control group. The fully automated web-based computer-tailored physical activity intervention consists of seven 10- to 15-min sessions over an 8-week period. The theoretical underpinning of the intervention is based on the I-Change Model. Results A repeated-measures ANOVA using a linear mixed model showed a significant ‘group-by-time’ interaction favoring the intervention group in self-reported MVPA (p = .02). The MVPA was similar in both groups at baseline (mean ± SD; 176 ± 13 vs. 172 ± 15 min/week, p = .72) and higher in the intervention than in the control group at a 3-month follow-up (259 ± 21 vs. 201 ± 22 min/week, p = .04). This finding was comparable across women and men (group-by-sex, p = .57) and across participants meeting or not physical activity guidelines at baseline (group-by-baseline physical activity, p = .43). Although engagement to the web-based sessions declined over time, participants completing more web sessions achieved higher self-reported MVPA (p < .05). Conclusion These findings suggest that this intervention is effective in enhancing self-reported MVPA in this adult population in the short term; however, this needs to be confirmed in a larger trial with better engagement to the web-based sessions.
Submarine groundwater discharge alters coral reef ecosystem metabolism

Submarine groundwater discharge (SGD) influences near-shore coral reef ecosystems worldwide. SGD biogeochemistry is distinct, typically with higher nutrients, lower pH, cooler temperature and lower salinity than receiving waters. SGD can also be a conduit for anthropogenic nutrients and other pollutants. Using Bayesian structural equation modelling, we investigate pathways and feedbacks by which SGD influences coral reef ecosystem metabolism at two Hawai'i sites with distinct aquifer chemistry. The thermal and biogeochemical environment created by SGD changed net ecosystem production (NEP) and net ecosystem calcification (NEC). NEP showed a nonlinear relationship with SGD-enhanced nutrients: high fluxes of moderately enriched SGD (Wailupe low tide) and low fluxes of highly enriched SGD (Kūpikipiki'ō high tide) increased NEP, but high fluxes of highly enriched SGD (Kūpikipiki'ō low tide) decreased NEP, indicating a shift toward microbial respiration. pH fluctuated with NEP, driving changes in the net growth of calcifiers (NEC). SGD enhances biological feedbacks: changes in SGD from land use and climate change will have consequences for calcification of coral reef communities, and thereby shoreline protection.
Turnover, Passage Population Size and Flight Range of Juvenile Ruddy Turnstones at a Non-Estuarine Staging Site in the Netherlands

For five consecutive years (2001–2005), during a one-month period in August–September, we studied the turnover of juvenile Ruddy Turnstones Arenaria interpres at a tidal area along the Dutch coast, by colour-marking cohorts of migrants. Taking turnover into account revealed that 1.8–2.4 times as many juvenile birds used the area during their southward migration, compared to the numbers based on maximum counts. This larger estimate amounts to 35% of the number at which the 1% criterion of the Ramsar Convention is met, whereupon a wetland is designated as internationally important, with significant implications for conservation commitments. Presuming adult birds had the same turnover factor, adult birds contributed almost 70% to the 1% criterion during the same period. Autumn migration of juvenile Ruddy Turnstones was rapid, with more than 50% of individuals leaving within 4 days (95%-CI: 3.4–4.6). The mean mass at departure, as derived from median staging duration and mean body mass gain from recaptured birds (1.1 g/d), was 104.3 g (±10.3 SD). The mean potential flight range as calculated using the aerodynamic approach by Pennycuick was 1981 km (±717 SD), which suggests that juvenile birds that leave the area can cover short to medium distances at most. The fuel loads are sufficient to reach one of the four key wintering sites along the coast of France, but not the Banc d'Arguin in Mauretania, which is the first key wintering site in West Africa. By early October, 80% of the birds had left the study area. Our study shows the importance of a small tidal area during autumn migration and raises the question of whether a considerable number of comparable small stopover sites along the coast of Western Europe and West Africa are needed. More attention to the designation and the protection of such sites and the achievement of a network would have the potential to greatly support juvenile birds on their first journey south.
The impact of family stressors and resources on military spouse’s perception of post-deployment reunion stress

ABSTRACT Much of the prior research on variables impacting spouses’ perceptions of reunion stress have focused on individual variables and have not examined these variables within their shared context, despite the indication from some research and theory that this is a key component of understanding couple’s responses to stressors. The present study examined the impact of various family stressors and resources, both independently and in conjunction with each other, on spouses’ perceptions of reunion stress. To examine these variables, the present study utilized cross-sectional data from a representative sample of 1,558 military service members and their spouses participating in the Millennium Cohort Family Study. Results indicated that poorer mental health among spouses and service members was associated with increased reunion stress as reported by spouses across all models tested. In addition, stressful communication during deployment was significantly associated with spouses’ perceptions of reunion stress. These results can help guide more targeted prevention and intervention efforts to decrease spouses’ sense of reunion stress.
Sleep attitudes as a predictor of sleep outcomes: a secondary data analysis

ABSTRACT Objectives Attitudes have been widely studied as predictors of a number of social and health behaviors. However, attitudes predicting sleep outcomes have only recently been examined, despite sleep being conceptualized as an important health behavior. Prior research has demonstrated that attitudes toward sleep are associated with sleep hygiene, sleep duration and quality (Peach & Gaultney, 2017; Peach, Gaultney, Ruggiero, 2018). Sleep attitudes interact with varying demographic identities, such as age, gender, race, and perceived socioeconomic status (SES) (Ruggiero, Peach, & Gaultney, 2019). The present study hypothesized that (1) sleep attitudes would be indirectly associated with sleep outcomes (duration and quality) via sleep hygiene, and, (2) this indirect effect would be modified by specific demographic variables (age, gender, race, and perceived SES; moderated mediation). Method One hundred and seventy-two adults from the United States completed an anonymous survey on sleep characteristics and health. Results Results confirmed the first hypothesis, indicating that sleep attitudes were significantly and indirectly associated with both sleep duration and sleep quality via sleep hygiene. Additionally, gender and SES further modified these significant indirect effects, meaning hypothesis two was partially supported. Conclusions Results are discussed in terms of their implications for the importance and variability of sleep attitudes, and future research directions are considered.
Remote Sensing of Spatial-Temporal Variation of Chlorophyll-a in the Jiaozhou Bay Using 32 Years Landsat Data

ABSTRACT Wu, M. ; Zhao, Y.F. ; Sun, L.E. ; Huang, J.; Wang, X.H. , and Ma, Y. , 2020. Remote sensing of spatial-temporal variation of chlorophyll-a in the Jiaozhou Bay using 32 years Landsat data. In: Jung, H. -S. ; Lee, S. ; Ryu, J.-H. , and Cui, T.W. (eds.), Advances in Geospatial Research of Coastal Environments. Journal of Coastal Research, Special Issue No. 102, pp. 271-279. Coconut Creek (Florida), ISSN 0749-0208. The chlorophyll-a concentration (Chla, µg/L) is a vital indicator of water quality and eutrophication, yet optical complexity and significant variability of coastal waters make the accurate estimation of Chla challenging. Monitoring spatial-temporal distribution and variation of Chla and comprehending the correlation between Chla and environmental factors are necessary for long-term water quality assessment. This study calibrated and validated the Chla estimation model with satisfactory performance (R2, RMSE, and MRE values are 0.77, 0.64 µg/L, and 32.5 %) and further characterized the spatial-temporal variation of Chla in Jiaozhou Bay (JZB) based on 381 cloud-free Landsat images of 32 years (1986-2017). The annual mean Chla in JZB reached the highest value in 1997 and decreased gradually in the following two decades. The seasonal variation of Chla is obvious: the highest value of Chla appeared in summer, followed by spring, autumn and winter. Accordingly, the monthly averaged Chla peaked in July, while the minimum occurred in January. The spatial distribution of Chla on different time scales shared a similar pattern. High Chla appeared in the northwestern part of JZB and decreased gradually to the southwest, resulting in the lowest Chla near the water channel connected to the open sea. The spatial heterogeneity mainly arose from river discharge, while the temporal heterogeneity may be caused by seasonal variations in precipitation, temperature, and river discharge. This study indicated that the empirical models for the Landsat data could effectively monitor the long-term Chla variation in JZB.