Miracle-dz/UniFAR-FTUs huggingface dataset:
Microbiological Retention on PTFE versus Silk Suture: A Quantitative Pilot Study in Third Molar Surgery

Background: Mandibular third molar (M3M) removal and management of postoperative complications represent a common matter of interest in oral and maxillofacial surgery. This potential quantitative study assessed the ability of two types of surgical sutures, Silk and polytetrafluoroethylene polymer (PTFE), to carry aerobic and anaerobic bacteria on wounds after mandibular third molar surgery, with a collection of the stitches at the suture removal and study in the laboratory on the basis of colony-forming units. Methods: This prospective quantitative study sampled a total of 10 consecutive healthy patients for mandibular third molar surgery at the Oral Surgery School, Dentistry and Dental Prosthodontics, Department of Medical Biotechnologies, University of Siena, Siena, Italy. The mean age of the patients was 31 years (range 25–40 years), seven patients were male and three patients were female. Inclusion criteria were: presence of a partially impacted mandibular third molar. Exclusion criteria were: smoking and diabetes mellitus. Extraction of the mandibular third molar was performed under local anesthesia: after the third molar surgery, two sutures were applied on the surgical site distally to the second mandibular molar: one single 3/0 silk stitch; one single 3/0 PTFE stitch. No sutures were applied on the release incision. Sutures were removed after 7 days and were immediately conserved and sent to the laboratory to be rated on the basis of colony-forming units (CFUs). CFUs were evaluated and reported on GraphPad Prism and transformed into its base 10 logarithm. Data were analyzed with a non-parametric Wilcoxon test, and p-values < 0.05 were evaluated as statistically significant. Results: All the patients attended the suture removal date, and all the sutures were present in the site. None of the surgical sites presented dehiscence. No stitch loss was reported, and no patient reported mouth washing or tooth brushing in the surgery site. All interventions were uneventful and no major complications were reported after M3M surgery. Bacterial retention resulted as statistically greater in silk sutures rather than PTFE sutures, both in Brain Heart Infusion samples (p = 0.003) and Wilkins-Chalgren anaerobe samples (p = 0.002). Conclusions: We found the PTFE suture to be superior to the silk suture in a reduction in the bacterial biofilm in both aerobic and anaerobic evaluations after M3M surgery.
The Role of Human Microbiota in Myasthenia Gravis: A Narrative Review

Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by fluctuating weakness of the skeletal muscles. Although antibodies against the neuromuscular junction components are recognized, the MG pathogenesis remains unclear, even if with a well-known multifactorial character. However, the perturbations of human microbiota have been recently suggested to contribute to MG pathogenesis and clinical course. Accordingly, some products derived from commensal flora have been demonstrated to have anti-inflammatory effects, while other have been shown to possess pro-inflammatory properties. In addition, patients with MG when compared with age-matched controls showed a distinctive composition in the oral and gut microbiota, with a typical increase in Streptococcus and Bacteroides and a reduction in Clostridia as well as short-chain fatty acid reduction. Moreover, restoring the gut microbiota perturbation has been evidenced after the administration of probiotics followed by an improvement of symptoms in MG cases. To highlight the role of the oral and gut microbiota in MG pathogenesis and clinical course, here, the current evidence has been summarized and reviewed.
A non-pharmacological multidomain intervention of dual-task exercise and social activity affects the cognitive function in community-dwelling older adults with mild to moderate cognitive decline: A randomized controlled trial

The present study aimed to determine the impact of a 10-month multidomain program using dual-task exercise and social activity conducted at a community-based facility on improved cognitive function in older adults with mild to moderate cognitive decline. The participants included 280 community-dwelling older adults (age 71–91 years) with mild to moderate cognitive decline. The intervention group exercised for 90 min/day, once a week. Their routine included aerobic exercise and dual-task training which cognitive tasks were performed in combination with exercise. The control group attended health education classes thrice. Before and after the intervention, we measured their cognitive function, physical function, daily conversation, and physical activity. The mean adherence rate of the intervention class was 83.0%. According to a repeated-measures multivariate analysis of covariance in an intent-to-treat analysis, logical memory and 6-min walking distance demonstrated a significant time and group interaction effect. Regarding daily physical activities, we observed significant differences in the daily step count and moderate-to-vigorous physical activity in the intervention group. Our non-pharmacological multidomain intervention resulted in a modest improvement in the cognitive or physical function and building health behavior. It may be a helpful program with a potential role in preventing dementia. Clinical Trial Registration: http://clinicaltrials.gov Identifier ID: UMIN000013097.
Twicing Kernels and a Small Bias Property of Semiparametric Estimators

The purpose of this note is to show how semiparametric estimators with a small bias property can be constructed. The small bias property (SBP) of a semiparametric estimator is that its bias converges to zero faster than the pointwise and integrated bias of the nonparametric estimator on which it is based. We show that semiparametric estimators based on twicing kernels have the SBP. We also show that semiparametric estimators where nonparametric kernel estimation does not affect the asymptotic variance have the SBP. In addition we discuss an interpretation of series and sieve estimators as idempotent transformations of the empirical distribution that helps explain the known result that they lead to the SBP. In Monte Carlo experiments we find that estimators with the SBP have mean-square error that is smaller and less sensitive to bandwidth than those that do not have the SBP. Copyright The Econometric Society 2004.
A Preliminary Study of Cell Death Dynamics with PFA Using an In Vitro 3D Cardiac Cell Model

Pulsed field ablation (PFA) has become a promising treatment technique for atrial fibrillation in the recent years. However, the further investigation of the time for characterizing the cardiac cell death after electroporation is required. In this study, five incubation times (0, 3, 6, 12, and 24 h) after electroporation at two different electric field strengths (1000 and 2500 V/cm) were selected to study the dynamics of cell death using an in vitro 3D cardiac cell model. The results achieved in this study demonstrate that the cell death rate changes with the incubation time and the changes are different between the electric field strengths of 1000 and 2500 V/cm. The future work on this difference between the low and high electric fields is warranted using a larger range of electric field strengths.
Colour and melanopsin mediated responses in the murine retina

Introduction: Intrinsically photosensitive retinal ganglion cells (ipRGCs) integrate melanopsin and rod/cone-mediated inputs to signal to the brain. Whilst originally identified as a cell type specialised for encoding ambient illumination, several lines of evidence indicate a strong association between colour discrimination and ipRGC-driven responses. Thus, cone-mediated colour opponent responses have been widely found across ipRGC target regions in the mouse brain and influence a key ipRGC-dependent function, circadian photoentrainment. Although ipRGCs exhibiting spectrally opponent responses have also been identified, the prevalence of such properties have not been systematically evaluated across the mouse retina or yet been found in ipRGC subtypes known to influence the circadian system. Indeed, there is still uncertainty around the overall prevalence of cone-dependent colour opponency across the mouse retina, given the strong retinal gradient in S and M-cone opsin (co)-expression and overlapping spectral sensitivities of most mouse opsins. Methods: To address this, we use photoreceptor isolating stimuli in multielectrode recordings from human red cone opsin knock-in mouse (Opn1mwR) retinas to systematically survey cone mediated responses and the occurrence of colour opponency across ganglion cell layer (GCL) neurons and identify ipRGCs based on spectral comparisons and/or the persistence of light responses under synaptic blockade. Results: Despite detecting robust cone-mediated responses across the retina, we find cone opponency is rare, especially outside of the central retina (overall ~3% of GCL neurons). In keeping with previous suggestions we also see some evidence of rod-cone opponency (albeit even more rare under our experimental conditions), but find no evidence for any enrichment of cone (or rod) opponent responses among functionally identified ipRGCs. Conclusion: In summary, these data suggest the widespread appearance of cone-opponency across the mouse early visual system and ipRGC-related responses may be an emergent feature of central visual processing mechanisms.
Variable selection and interpretation in correlation principal components

Principal component analysis (PCA) is a dimension‐reducing tool that replaces the variables in a multivariate data set by a smaller number of derived variables. Dimension reduction is often undertaken to help in interpreting the data set but, as each principal component usually involves all the original variables, interpretation of a PCA can still be difficult. One way to overcome this difficulty is to select a subset of the original variables and use this subset to approximate the principal components. This article reviews a number of techniques for choosing subsets of the variables and examines their merits in terms of preserving the information in the PCA, and in aiding interpretation of the main sources of variation in the data. Copyright © 2005 John Wiley & Sons, Ltd.
Nanoencapsulation of 3-Chloropropylaminobenzoate Derivatives with Potential Insecticidal Activity

: Aminobenzoic acid derivatives have shown various pharmacological properties, one of which is pesticide activity, giving these compounds the ability to work as alternatives to current pesticides. Nanotechnology could efﬁciently support the use of these compounds by encapsulating them in stable nanoformulations to improve their stability and effectiveness. In the present work, 3-chloropropylaminobenzoate derivatives were synthesised and evaluated against their effect on the viability of the insect cell line Sf9 ( Spodoptera frugiperda ), and nanoencapsulation studies of the most active compound were carried out. The most potent molecules reduced insect cell viability by around 40% at 100 µ g/mL.
Thermal requirements, fertility life table and biological parameters of Cleruchoides noackae (Hymenoptera: Mymaridae) at different temperatures

Cleruchoides noackae Lin & Huber (Hymenoptera: Mymaridae) was imported to Brazil in 2012, to manage the exotic pest Thaumastocoris peregrinus Carpintero & Dellapé (Hemiptera: Thaumastocoridae), which has been damaging eucalyptus plantations. Knowledge of the thermal requirements and the fertility life table of C. noackae is important to improve mass rearing methods for this parasitoid and the effectiveness of its release to manage T. peregrinus. The objective was to evaluate the development period, thermal requirements and the fertility life table of C. noackae at different temperatures. The egg-adult period of this parasitoid varied from 43 to 14 days at 15 °C and 30 °C, respectively. The emergence of C. noackae adults was higher at 15 °C, 18 °C, 21 °C and 24 °C than at 30 °C. Female and male C. noackae need 226.75 and 230.41 degree-days and temperatures higher than 10.06 °C and 9.90 °C, respectively, to complete egg-adult development. The number of parasitized eggs per C. noackae female was higher at 21 °C, 24 °C and 27 °C, with 5.82, 7.73 and 5.50 eggs, respectively, than at 30 °C (0.45). Cleruchoides noackae longevity was greater at 15 °C, 21 °C and 24 °C. The net reproductive rate of the parasitoid was higher at 21 °C and 24 °C than at 30 °C, 3.05, 4.70 and 0.16, respectively. The finite rate of increase of C. noackae was greater at 21 °C, 24 °C and 27 °C, than at 30 °C and the intrinsic rate of increase was negative at 30 °C, −0.100. The temperatures 21 °C and 24 °C and from 18 °C to 27 °C are the most adequate for the reproduction and population increase of C. noackae parasitizing eggs of T. peregrinus, respectively.
Synthesis and investigation on microstructural, mechanical features of mesoporous hardystonite/reduced graphene oxide nanocomposite for medical applications

The use of hardystonite (Ca2ZnSi2O7, HT)-based composites could be one the main strategies to improve mechanical properties closing to natural bone. However, there are a few reports in this regard. Recent findings indicate that graphene is a promising biocompatible additive in ceramic-based composite. Here, we propose a simple approach for the synthesis of porous nano- and microstructured hardystonite/reduced graphene oxide (HT/RGO) composite using a sol-gel method followed by ultrasonic and hydrothermal processes. Integrating GO to the pure HT increased the bending strength and toughness values about 27.59% and 34.33%, respectively. It also allowed the increment of compressive strength and compressive modulus by about 8.18% and 86%, respectively, and improvement in the fracture toughness about 11.8 times compared to pure HT. The formation of HT/RGO nanocomposites with different RGO weight percentages ranging from 0 to 5.0 has been investigated by scanning electron microscopy (SEM) and X-ray diffraction and the efficient incorporation of GO nanosheets into HT nanocomposite as well as the mesoporous structural properties were also confirmed by Raman, FTIR and BET analyses. The cell viability of HT/RGO composite scaffolds was assayed by methyl thiazole tetrazolium (MTT) test in vitro. In this regard, the alkaline phosphatase (ALP) activity and the proliferation rate of mouse osteoblastic cells (MC3T3-E1) on the HT/1 wt. % RGO composite scaffold enhanced in comparison with the pure HT ceramic. The adhesion of osteoblastic cells on the 1% wt. HT/RGO scaffold was interesting as well. In addition, the effect of 1% wt. HT/RGO extract on the proliferation of osteoblast human G-292 cells was successfully evaluated and remarkable observations were obtained. All together it can be said that the proposed bioceramic hardystonite/reduced graphene oxide composites can be a promising candidate for designing hard tissue implants. Graphical Abstract
Sparseness for the symmetric hit problem at all primes

Abstract The hit problem for a module over the Steenrod algebra $\mathcal{A}$ seeks a minimal set of $\mathcal{A}$-generators (“non-hit elements,” those not in the image of positive degree elements of $\mathcal{A}$). This problem has been studied for 25 years in a variety of contexts and, although general or complete results have been difficult to obtain, partial results have been obtained in many cases. For any prime p ⩾ 2, consider the algebra of symmetric polynomials in l variables over $\mathbb{F}$p (the cohomology of BU(l) [BO(l) for p = 2]). We prove a general sparseness result: For any l, the $\mathcal{A}$-generators can be concentrated in complex [real for p = 2] degrees τ such that α((p - 1) (τ + l)) ⩽(p - 1)l, where α(m) denotes the sum of the digits in the p-ary expansion of m. The specialisation of this result to p = 2 was proved by Janfada and Wood using different methods. Key ingredients of our approach are an action of the Kudo–Araki–May algebra on the $\mathcal{A}$-primitives in homology, and a symmetric homology adaptation of the concept behind the χ-trick in cohomology.
Kinetic model for radiation-induced attenuation in silica-based optical fibers: analysis of generation and annihilation of two leading color center defects

In this study, a radiation-induced attenuation (RIA) kinetic model based on color center density is developed by considering the effects of dose, dose rate, and temperature on RIA in optical fibers. Due to the different experimental conditions of fiber irradiation decay-related studies, there are differences in RIA kinetic models based on different fiber types, dopants, and irradiation dose ranges. Based on the paper of typical comparison scope, this paper constructs an RIA model with certain generality. The proposed RIA kinetic model successfully fits the correspondence between RIA and dose, dose rate, and temperature parameters in different optical fibers. The research results will provide a theoretical basis and data reference for the application selection and whole life cycle assessment of fiber-optic communication systems in the field of the particular radiation environment.
Comparison between audio-vestibular findings and contrast-enhanced MRI of inner ear in patients with unilateral Ménière’s disease

Objective The diagnosis of Ménière’s disease (MD), characterized by idiopathic endolymphatic hydrops (ELH), remains a clinical priority. Many ancillary methods, including the auditory and vestibular assessments, have been developed to identify ELH. The newly emerging delayed magnetic resonance imaging (MRI) of the inner ear after intratympanic gadolinium (Gd) has been used for identifying ELH in vivo. We aimed to investigate the concordance of audio-vestibular and radiological findings in patients with unilateral MD. Methods In this retrospective study, 70 patients with unilateral definite MD underwent three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) sequences following intratympanic application of Gd. Audio-vestibular evaluations were performed, including pure tone audiometry, electrocochleogram (ECochG), glycerol test, caloric test, cervical and ocular vestibular evoked myogenic potentials (VEMPs), and video head impulse test (vHIT). The relationship between imaging signs of ELH and audio-vestibular results was investigated. Results The incidence of radiological ELH was higher than that of neurotological results, including the glycerol test, caloric test, VEMPs, and vHIT. Poor or slight agreement was observed between audio-vestibular findings and radiological ELH in cochlear and/or vestibular (kappa values <0.4). However, the pure tone average (PTA) in the affected side significantly correlated with the extent of both cochlear (r = 0.26795, p = 0.0249) and vestibular (r = 0.2728, p = 0.0223) hydrops. Furthermore, the degree of vestibular hydrops was also positively correlated with course duration (r = 0.2592, p = 0.0303) and glycerol test results (r = 0.3944, p = 0.0061) in the affected side. Conclusion In the diagnosis of MD, contrast-enhanced MRI of the inner ear is advantageous in detecting ELH over the conventional audio-vestibular evaluations, which estimates more than hydropic dilation of endolymphatic space.
The Imprint of Exposome on the Development of Atopic Dermatitis across the Lifespan: A Narrative Review

Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects more than 200 million people worldwide, including up to 20% of children and 10% of the adult population. Although AD appears frequently in childhood and often continues into adulthood, about 1 in 4 adults develop the adult-onset disease. The prenatal period, early childhood, and adolescence are considered critical timepoints for the development of AD when the exposome results in long-lasting effects on the immune system. The exposome can be defined as the measure of all the exposures of an individual during their lifetime and how these exposures relate to well-being. While genetic factors could partially explain AD onset, multiple external environmental exposures (external exposome) in early life are implicated and are equally important for understanding AD manifestation. In this review, we describe the conceptual framework of the exposome and its relevance to AD from conception and across the lifespan. Through a spatiotemporal lens that focuses on the multi-level phenotyping of the environment, we highlight a framework that embraces the dynamic complex nature of exposome and recognizes the influence of additive and interactive environmental exposures. Moreover, we highlight the need to understand the developmental origins of AD from an age-related perspective when studying the effects of the exposome on AD, shifting the research paradigm away from the per se categorized exposome factors and beyond clinical contexts to explore the trajectory of age-related exposome risks and hence future preventive interventions.
Preparation and Properties Study of Wood-Based Cushioning Materials

Traditional cushioning package materials, such as Expended Polystyrene (EPS) and Expanded Polyethylene (EPE), were made with petroleum-based plastics, which are harmful to the environment. It is crucial to develop renewable bio-based cushioning materials that can replace the aforementioned foams due to the rising energy demands of human society and the depletion of fossil fuels. Herein, we report an effective strategy for creating anisotropic elastic wood with special spring-like lamellar structures. Selective removal of lignin and hemicellulose by simple chemical treatment and thermal treatment of the samples after freeze-drying results in an elastic material with good mechanical properties. The resulting elastic wood has a reversible compression rate of 60% and a high elastic recovery (99% height retention after 100 cycles at 60% strain). Drop tests revealed that the elastic wood has excellent cushioning properties. In addition, the chemical and thermal treatments also enlarge the pores in the material, which is favorable for subsequent functionalization. By loading the elastic wood with a muti-walled carbon nanotube (MWCNT), electromagnetic shielding properties are achieved, while the mechanical properties of elastic wood remain unchanged. Electromagnetic shielding materials can effectively suppress various electromagnetic waves propagating through space and the resulting electromagnetic interference and electromagnetic radiation, improve the electromagnetic compatibility of electronic systems and electronic equipment, and ensure the safety of information.
Development of an efficient praseodymium-doped fiber amplifier

This paper describes the development of an efficient praseodymium-doped fluoride fiber amplifier (PDFA) using newly developed PbF/sub 2/-InF/sub 3/-based fluoride single-mode fiber. First, the spectroscopic properties of Pr/sup 3+/ in PbF/sub 2/-InF/sub 3/-based and ZrF/sub 4/-based fluoride glass are compared and then the fabrication of high-NA PbF/sub 2/-InF/sub 3/-based fluoride single-mode fiber is presented. The gain coefficients obtained with the developed fiber are 0.36 dB/mW with a forward pumping scheme and 0.4 dB/mW with a bidirectional pumping scheme. We use this newly developed fiber to construct two types of an efficient PDFA module. We realized a 19-in rack size PDFA module with a master oscillator/power amplifier laser diode (MOPA-LD) and a plug-in type PDFA module with a wavelength-stabilized 1.017-/spl mu/m LD and describe their amplification characteristics.