Miracle-dz/UniFAR-FTUs huggingface dataset:
Update on sex specific risk factors in cardiovascular disease

Cardiovascular disease (CVD) is the leading cause of death worldwide and accounts for roughly 1 in 5 deaths in the United States. Women in particular face significant disparities in their cardiovascular care when compared to men, both in the diagnosis and treatment of CVD. Sex differences exist in the prevalence and effect of cardiovascular risk factors. For example, women with history of traditional cardiovascular risk factors including hypertension, tobacco use, and diabetes carry a higher risk of major cardiovascular events and mortality when compared to men. These discrepancies in terms of the relative risk of CVD when traditional risk factors are present appear to explain some, but not all, of the observed differences among men and women. Sex-specific cardiovascular disease research—from identification, risk stratification, and treatment—has received increasing recognition in recent years, highlighting the current underestimated association between CVD and a woman's obstetric and reproductive history. In this comprehensive review, sex-specific risk factors unique to women including adverse pregnancy outcomes (APO), such as hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus, preterm delivery, and newborn size for gestational age, as well as premature menarche, menopause and vasomotor symptoms, polycystic ovarian syndrome (PCOS), and infertility will be discussed in full detail and their association with CVD risk. Additional entities including spontaneous coronary artery dissection (SCAD), coronary microvascular disease (CMD), systemic autoimmune disorders, and mental and behavioral health will also be discussed in terms of their prevalence among women and their association with CVD. In this comprehensive review, we will also provide clinicians with a guide to address current knowledge gaps including implementation of a sex-specific patient questionnaire to allow for appropriate risk assessment, stratification, and prevention of CVD in women.
Mesenchymal Stromal Cells Derived from Dental Tissues: Immunomodulatory Properties and Clinical Potential

Mesenchymal stem/stromal cells (MSCs) are multipotent cells located in different areas of the human body. The oral cavity is considered a potential source of MSCs because they have been identified in several dental tissues (D-MSCs). Clinical trials in which cells from these sources were used have shown that they are effective and safe as treatments for tissue regeneration. Importantly, immunoregulatory capacity has been observed in all of these populations; however, this function may vary among the different types of MSCs. Since this property is of clinical interest for cell therapy protocols, it is relevant to analyze the differences in immunoregulatory capacity, as well as the mechanisms used by each type of MSC. Interestingly, D-MSCs are the most suitable source for regenerating mineralized tissues in the oral region. Furthermore, the clinical potential of D-MSCs is supported due to their adequate capacity for proliferation, migration, and differentiation. There is also evidence for their potential application in protocols against autoimmune diseases and other inflammatory conditions due to their immunosuppressive capacity. Therefore, in this review, the immunoregulatory mechanisms identified at the preclinical level in combination with the different types of MSCs found in dental tissues are described, in addition to a description of the clinical trials in which MSCs from these sources have been applied.
Students’ perspectives on their early dropout of medical school

BACKGROUND: Enrolling in medical school launches a more demanding and stressful way of life for newly admitted students. Some students will struggle academically and will ultimately drop out from medical school. The study aims to understand the perspectives that dropped-out students have and their opinion regarding possible preventative solutions. MATERIALS AND METHODS: This study uses a mixed-method approach. The results of students’ examinations in the first 2 years of admission (within four academic years from 2016 until 2020) were collected from the medical school records. A questionnaire was developed to investigate the causes of early attrition during the study period. All dropped-out students who were admitted were included in this study. RESULTS: The study included 479 admitted students, 349 (72.9%) were females; 152 (31.7%) students dropped out in the premedical program (first two years); 104 (68.4%) of the dropped-out students were females. Thirty-five (23%) students responded to the questionnaire. Twenty-eight (80%) respondents believed that their low academic performance and leaving medical school was primarily related to psychological problems, 19 (54%) of respondents reported leaving for social reasons, and lack of self-organization in 13 (37.1%) respondents. Human anatomy was recorded as the most difficult course in the first year by 21 (63.6%) students. CONCLUSIONS: The cause of attrition is often multifactorial and complex. Psychological problems are one of the important factors in students with low academic performance and dropping out of the students. Some difficult courses in the curriculum may affect the students’ academic performance leading to their attrition.
The modified coastal storm impulse parameter

THE MODIFIED COASTAL STORM IMPULSE (COSI) PARAMETER Sayed Gholamreza Mahmoudpour Old Dominion University, 2012 Director: Dr. David R. Basco, P.E. The correlation of the morphological changes to the coast and storm characteristics is among interests of coastal engineers. Better understandings of a storm's potential forces ultimately lead engineers to safer designs and minimize the damages. Therefore, a need to quantify the storm potential forces to a storm parameter is evident. The desired storm parameter is to consider all the relative physical factors and is to present realistic results that then can be proven by actual nature response. The concept of Coastal Storm Impulse (COSI) parameter was first introduced by Basco and Klentzman (2006) and is based on the conservation of horizontal momentum to combine storm surge, wave dynamics, and currents over the storm duration and here is referred to as original COSI parameter. The COSI parameter consists of three components of wave, surge and current momentum. The current momentum is not considered in the original COSI parameter since it was not significant in compare to the wave and surge momentum (Klentzman, 2007). It is not considered in this dissertation for the Modified COSI parameter in order to keep the consistency of the analysis. In this dissertation, steps have been taken to examine and to redefine the criterion of storm definition, wave momentum and surge momentum in order to improve shortcomings of original COSI parameter. For the Modified COSI parameter, the estimation of wave momentum integrated over the water depth and averaged over the wave period utilizing nonlinear (Fourier) wave theory is introduced for the first time. A computer FORTRAN code developed within the Hydraulic and Coastal Group in the Department of Civil Engineering at University of California, Berkeley is used to develop a set of empirical formulas to estimate the wave momentum. Also, the importance of tides in beach stability has been noted and is considered by applying water elevations above Mean High Water (MHW) to obtain the storm surge momentum. The Modified COSI Parameter introduced here is sum of the wave momentum and the surge momentum. For a "storm event" it was assumed that the wave height will stay at or above 1.6 meter for 12 hours to have a chance to ride on the high tide and it is based on a tidal cycle of approximately 12 hours. The data set for year 1994-2003 at USACE Field Research Facility (FRF), Duck, NC, has been reanalyzed based on the new methodology and criterion set forth in this dissertation. This new approach has produced 148 storms in compare to 160 storms from original COSI results (Klentzamn, 2007) over the period of 10 years the data (1994-2003). The analyses of the 10-year data (1994-2003) show a better proportionality of the wave momentum (60%) and the storm surge momentum (40%) to the total momentum. In general the average wave momentum resulting from empirical formulation introduced in this dissertation is in average 10 times smaller than the maximum wave momentum from Hughes (2004) formulation.
Molecular Targeting of the Phosphoinositide-3-Protein Kinase (PI3K) Pathway across Various Cancers

The dysregulation of the phosphatidylinositol-3-kinase (PI3K) pathway can lead to uncontrolled cellular growth and tumorigenesis. Targeting PI3K and its downstream substrates has been shown to be effective in preclinical studies and phase III trials with the approval of several PI3K pathway inhibitors by the Food and Drug Administration (FDA) over the past decade. However, the limited clinical efficacy of these inhibitors, intolerable toxicities, and acquired resistances limit the clinical application of PI3K inhibitors. This review discusses the PI3K signaling pathway, alterations in the PI3K pathway causing carcinogenesis, current and novel PI3K pathway inhibitors, adverse effects, resistance mechanisms, challenging issues, and future directions of PI3K pathway inhibitors.
Salmonella Contamination of Fresh Salad Produce: Prevalence, Impact and Reduction Strategies

Fresh salad produce such as lettuce and spinach are an important part of a healthy diet, but are increasingly becoming associated with infection from foodborne pathogens such as Salmonella enterica. This review examines the incidence and origins of Salmonella fresh salad leaf colonization, models the behaviour of the pathogen when within a bagged salad and considers the various infection risk reduction strategies relevant to salad growers, distributors and consumers which can be employed to improve the microbiological safety of fresh salad leaves Abstract
Extracellular Vesicles in the Pathogenesis, Clinical Characterization, and Management of Dermatomyositis: A Narrative Review

Extracellular vesicles (EVs) are lipid-bilayer particles secreted from cells that primarily assist in cell-to-cell communication through the content of their cargo, such as proteins and RNA. EVs have been implicated in the pathogenesis of various autoimmune diseases, including dermatomyositis (DM), an inflammatory autoimmune disease characterized by distinct cutaneous manifestations, myopathy, and lung disease. We sought to review the role of EVs in DM and understand how they contribute to the pathogenesis and clinical characterization of the disease. We summarized the research progress on EVs in dermatomyositis based on recent publications. EV cargoes, such as double-stranded DNA, microRNA, and proteins, contribute to DM pathogenesis and mediate the proinflammatory response and cytokine release through signaling pathways such as the stimulator of interferon genes (STING) pathway. These nucleic acids and proteins have been proposed as disease-specific, stable biomarkers to monitor disease activity and responses to therapy. They also correlate with clinical parameters, inflammatory markers, and disease severity scores. Furthermore, some markers show an association with morbidities of DM, such as muscle weakness and interstitial lung disease. The continued study of EVs will help us to further elucidate our understanding of dermatomyositis.
One Anastomosis Gastric Bypass vs. Sleeve Gastrectomy in the Remission of Type 2 Diabetes Mellitus: A Retrospective Analysis on 3 Years of Follow-Up

Background. Obesity is a prevalent condition associated with various comorbidities, impacting mortality, fertility, and quality of life. Its relationship with type 2 diabetes mellitus (DMII) is well established, with nearly 44% prevalence. Bariatric surgery has proven crucial for treating both obesity and DMII. The comparison between surgical techniques, such as sleeve gastrectomy (SG) and one anastomosis gastric bypass (OAGB), remains controversial in terms of glycemic control efficacy. This retrospective study aimed to assess DMII remission efficacy between SG and OAGB after 36 months. Methods. From January 2016 to September 2020, 201 patients who underwent SG and OAGB for morbid obesity associated with DMII were accurately followed-up with for 36 months, focusing on %HbA1c, DMII remission, anthropometric results, and nutrient deficiency. Results. Although DMII remission did not exhibit statistical significance between the groups (82% vs. 93%, SG vs. OAGB, p = 0.051), OAGB demonstrated a more robust association with glycemic control (Odds Ratio 0.51) throughout the entire follow-up and yielded superior anthropometric outcomes. Notably, nutrient deficiencies, excluding cholecalciferol, iron, and riboflavin, did not show significant intergroup differences. Conclusions. This study contributes valuable insights into the extended-term efficacy of SG and OAGB in DMII remission. The nuanced findings underscore the multifaceted nature of metabolic outcomes, suggesting that factors beyond weight loss influence diabetes resolution. Larger comparative studies are warranted to comprehensively address this issue.
Evaluation of Thymus vulgaris and Thymbra spicata essential oils and plant extracts for chemical composition, antioxidant, and antimicrobial properties

Abstract The objectives of this study were (a) to obtain the essential oils (by hydrodistillation [HD] and microwave‐assisted extraction [MAE] methods) to determine the effect of the oil extraction method on the chemical composition, oil yield (%), free radical scavenging activity (IC50), ferric reducing antioxidant power (FRAP) value, and antimicrobial properties of Thymus vulgaris (thyme) and Thymbra spicata (zahter); and (b) to determine the effect of different solvents (methanol [80%] and ethanol [80%]) on extraction by means of the phenolic acid composition, total phenolic content, total flavonoid content, IC50, and FRAP value of thyme and zahter. Gas chromatography–mass spectrometry analysis showed that the amount of thymol (55.35%; 50.53%) and p‐cymene (11.2%; 11.79%) was found to be highest in thyme, when using HD and MAE, respectively. However, the highest amounts of carvacrol (68.20%; 66.91%) and γ‐terpinene (13.25%; 13.94%) were found in zahter, when using HD and MAE, respectively. Thyme essential oil had higher antioxidant capacity for both HD and MAE in comparison with zahter essential oil. Methanol extracts of both thyme and zahter had higher phenolic composition in comparison with their ethanol extracts. Extracts of both plants did not show any antimicrobial properties. However, essential oils of both thyme and zahter showed antimicrobial activity against chosen bacteria. Highest inhibition zone (radius) was shown against Staphylococcus aureus ATCC 9144 by the essential oils.
Which types of social support matter for Black sexual minority men coping with internalized homophobia? Findings from a mediation analysis

Background Minority stress theory views social support as a protective factor against the effects of minority-specific stressors like internalized homophobia (IH) on mental health in sexual minority populations. However, much of the empirical validation of this theory has been conducted within predominantly White samples, resulting in a limited understanding of how the theory applies to Black sexual minority individuals. Current examinations of social support fail to capture the nuances of how Black sexual minority men may access support systems differently, resulting in a need to investigate how social support, IH, and mental health operate for Black sexual minority men. This study examined relationships between IH, depression, and different types of social support (i.e., family, friends, Black community, gay community) using a mediation model. Methods We used data from the POWER (Promoting Our Worth Equity and Resilience) Study, which recruited Black sexual minority men at Black Pride events across six cities in the United States from 2014 to 2017, to test four mediation pathways concurrently in Stata 17. Participants (N = 4,430) completed a questionnaire assessing a variety of health and life domains, including depression symptoms, internalized homophobia, and social support. Results IH was positively associated with depression. Lower levels of family, friend, and Black community support were all positively associated with depression symptoms. Additionally, IH was positively associated with all types of support. Finally, family, friend, and Black community support partially mediated the relationship between IH and depression. Conclusions and implications Results suggest that the relationship between social support and depression is complex for Black sexual minority men. Findings suggest family support is an important factor for clinical intervention efforts targeting depression, and that gay community support systems should assess how their environments can better support Black sexual minority men. Overall, findings demonstrate the necessity of future examination of how social support functions differently within Black sexual minority communities.
Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas

Simple Summary This retrospective study aimed to analyze ADC values in the tissue surrounding enhancing gliomas and in the normal-appearing white matter. The goal was to find potential correlations of these values with treatment response and survival of patients. Patients, divided into short and long survival groups, underwent stereotactic biopsy or maximal surgical resection, followed by concomitant radio-chemotherapy. Baseline and follow-up MRI scans revealed significant differences in NAWM ADC values between the groups. Overall, the study suggests that ADC values in NAWM could serve as a prognostic biomarker for diffuse glioma patients. Abstract This study aimed to evaluate potential posttreatment changes in ADC values within the tissue surrounding the enhancing lesion, particularly in areas not exhibiting MRI characteristics of involvement. Additionally, the objective was to investigate the correlations among ADC values, treatment response, and survival outcomes in individuals diagnosed with gliomas. This retrospective study included a total of 49 patients that underwent either stereotactic biopsy or maximal surgical resection. Histologically confirmed as Grade III or IV gliomas, all cases adhered to the 2016 and 2021 WHO classifications, with subsequent radio-chemotherapy administered post-surgery. Patients were divided into two groups: short and long survival groups. Baseline and follow-up MRI scans were obtained on a 1.5 T MRI scanner. Two ROI circles were positioned near the enhancing area, one ROI in the NAWM ipsilateral to the neoplasm and another symmetrically in the contralateral hemisphere on ADC maps. At follow-up there was a significant difference in both ipsilateral and contralateral NAWM between the two groups, −0.0857 (p = 0.004) and −0.0607 (p = 0.037), respectively. There was a weak negative correlation between survival and ADC values in ipsilateral and contralateral NAWM at the baseline with the correlation coefficient −0.328 (p = 0.02) and −0.302 (p = 0.04), respectively. The correlation was stronger at the follow-up. The findings indicate that ADC values in normal-appearing white matter (NAWM) may function as a prognostic biomarker in patients with diffuse gliomas.
Effects of Technology-assisted on the Level of Performance and Engagement of BSED Mathematics

This study investigates the effects of technology-assisted lessons on the performance and engagement of Bachelor of Science in Education (BSED) Mathematics students enrolled in Calculus II. A pre-experimental design with a one-group pretest-post-test approach was employed. The respondents of the study were the 3rd-year BSED Mathematics students of Central Bicol State University of Agriculture-Sipocot for the 2023-2024 school year. Technology was integrated into the lessons through educational PowerPoint and video presentations during two sessions. Pre-tests and posttests were conducted to assess students’ performance in Calculus II, while survey questionnaires were used to measure the level of their engagement. The results of the Paired t-test reveal a significant (N=40, t=-30.691, p= 0.000) improvement in student performance following technology-assisted lessons. Findings also revealed that the level of engagement of the students towards Calculus II improved through the help of technology-assisted lessons. The study highlights the potential of technological integration in mathematics education and provides recommendations for further enhancing students’ learning experiences in Calculus II.
Introduction of Structural Health Monitoring to Civil Engineering Education

This paper describes the development of a Structural Health Monitoring (SHM) Education Unit; its initial implementation and assessment at Louisiana State University (LSU) and the University of LouisianaLafayette (UL-Lafayette) during the 2016-17 Academic Year; and its subsequent reimplementation and assessment during the 2017-18 Academic Year at these institutions plus its initial implementation at four partner institutions  Case Western Reserve University, Tuskegee University, University of North Florida and Virginia Tech. The SHM Education Unit encompasses the Fundamentals Education Subunit and the Applications Education Subunit. The Fundamentals Education Subunit consists of an introductory and four content online modules whereas the Applications Education Subunit consists of two content online modules, a SHM system design/evaluation module and a SHM instrumentation model demonstration. Using a pedagogical model developed during the project, the former Subunit is implemented in two classes of a structural analysis course whereas the latter Subunit is implemented in two classes of a reinforced concrete design course. The results of readiness tests and student assessments demonstrate the effectiveness of the content and the pedagogical model to engage students and teach SHM fundamentals and practices.
Qualitative and Quantitative Electrocardiogram Parameters in a Large Cohort of Children with Duchenne Muscle Dystrophy in Comparison with Age-Matched Healthy Subjects: A Study from South India

Background: Electrocardiography (ECG) remains an excellent screening tool for cardiac assessment in Duchenne muscular dystrophy (DMD), but an accurate interpretation requires comparison with age-matched healthy controls. Objective: We examined various ECG parameters in children with DMD, in comparison with age-matched controls. Methods: Standard 12-lead ECG tracings of serial patients were screened for quality and selected. Controls were healthy, age-matched school-going children. Both quantitative and qualitative ECG parameters were analyzed. Results: After screening, ECGs from 252 patients with DMD (8.32 ± 3.12 years, 2–21 years) and ECGs from 151 age-matched healthy controls (9.72 ± 2.23, 4–19 years) were included. A significantly higher heart rate, shorter R–R interval, and taller R wave in V1 were seen across all age group of DMD in comparison to controls, with the difference increasing with age. While QT prolongation was seen in all age groups of DMD, QTc prolongation was seen only at 10 years or more. Incomplete right bundle branch block (RBBB) and pathological Q waves in inferolateral leads were exclusive in DMD, with the latter declining with age. Evidence for left ventricular (LV) pathology, such as tall R in V5/V6, increase in SV1 + RV6 height, and QRS complex duration, were seen only in the age group of 10 years or more. Conclusion: Stratification based on age and comparison with age-matched healthy subjects showed that several ECG parameters were influenced by age, and it also identified age-dependent evidence for LV pathology and QTc prolongation in DMD.