Miracle-dz/UniFAR-FTUs huggingface dataset:
Do younger generations care more about environmental issues? A comparison of perceptions between Gen Z and Gen X in Jo-hannesburg, South Africa

ABSTRACT Many studies around the world have shown differences between generational cohorts in levels of concern about global environmental change. Global environmental change caused by the anthropogenic practices poses a threat to human life as well as biodiversity, and it is perpetuated by the lack of awareness of environmental sustainability. To spread awareness where it is lacking, it is important to determine which generation is more concerned about global environmental change. This study analysed the Knowledges, Attitudes and Practices of Gen X and Gen Z to determine which one is more concerned about global environmental change. There were no significant differences seen between the two generations in their respective levels of green knowledgeand their level of concern for climate change and environmental problems. There was, however, a significant difference in the peer discussions on global warming of the two cohorts; the results revealed that discussions are more common in the Gen X cohort. Investigating environmental perceptions in light of generational cohorts is of importance to environmental groups seeking to communicate with different generational cohorts to push the climate change movement forward, strategise better for climate adaptation plans and for policy makers to better advocate for climate action.
Association of Traumatic Knee Injury With Radiographic Evidence of Knee Osteoarthritis in Military Officers

The association between knee injury and knee osteoarthritis (OA) is understudied relative to its importance, particularly in younger populations. This study was undertaken to examine the association of knee injury with radiographic features of knee OA in military officers, who have a physically demanding profession and high rates of knee injury.
Time-resolved spectroscopy and photometry of the eclipsing AM Herculis binary EXO 033319 - 2554. 2

Time-resolved optical observations of the eclipsing AM Herculis binary EXO 033319 - 2554.2 are presented. High-speed photometry of an eclipse is presented and used to derive a new ephemeris for the system and to estimate the size of the region responsible for the cyclotron emission. Optical spectra that span the orbital cycle are presented, the cyclotron emission in these spectra is discussed, and the flux and radial velocity variations of H-beta, H-gamma, and He II 4686 A are examined. Models of the flux and radial velocity variations of the emission lines indicate that about half the line emission comes from low-velocity material that is about 1.4 x 10 to the 10th cm from the white dwarf. The rest comes from high-velocity material that is about 10 to the 10th cm from the white dwarf and is moving toward it at about 600 km/s. 13 refs.
Implementation of Islamic values in ISMUBA curriculum to form a Rabbani generation at Muhammadiyah Sidareja High School

Indonesia's young generation is currently experiencing moral degradation due to various factors. Muhammadiyah as a large Islamic organization in Indonesia has the responsibility to educate students in Muhammadiyah schools to become a Rabbani generation in accordance with Islamic values. The purpose of this study is to analyze how the implementation of the ISMUBA curriculum at SMA Muhammadiyah Sidareja as an initial reference to form students as a Rabbani generation. This type of research is This research is descriptive qualitative research in the form of field research, collecting primary data through interviews from the principal, the head of the curriculum, the Muhammadiyas subject teacher. the results of this research show ISMUBA as a curriculum in Muhammadiyah schools is one of the breakthroughs to be able to overcome the problem of moral degradation. However, in running ISMUBA, a synergistic relationship between parents and teachers is needed, so that the goal of forming a Rabbani generation with Qur’anic spirit can be achieved.
Platelet-Rich Plasma in Chronic Wound Management: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Background: Chronic wounds place a heavy burden on the healthcare system due to the prolonged, continuous need for human resources for wound management. Our aim was to investigate the therapeutic effects of platelet-rich plasma on the treatment of chronic wounds. Methods: The systematic literature search was performed in four databases. Randomized clinical trials reporting on patients with chronic wounds treated with platelet-rich plasma (PRP) were included, comparing PRP with conventional ulcer therapy. We pooled the data using the random effects model. Our primary outcome was the change in wound size. Results: Our systematic search provided 2688 articles, and we identified 48 eligible studies after the selection and citation search. Thirty-three study groups of 29 RCTs with a total of 2198 wounds showed that the odds for complete closure were significantly higher in the PRP group than in the control group (OR = 5.32; CI: 3.37; 8.40; I2 = 58%). Conclusions: PRP is a safe and effective modality to enhance wound healing. By implementing it in clinical practice, platelet-rich plasma could become a widely used, valuable tool as it could not only improve patients’ quality of life but also decrease the healthcare burden of wound management.
Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis

Nocturnal hypoxaemia, which is common in chronic obstructive pulmonary disease (COPD) patients, is associated with skeletal muscle loss or sarcopenia, which contributes to adverse clinical outcomes. In COPD, we have defined this as prolonged intermittent hypoxia (PIH) because the duration of hypoxia in skeletal muscle occurs through the duration of sleep followed by normoxia during the day, in contrast to recurrent brief hypoxic episodes during obstructive sleep apnoea (OSA). Adaptive cellular responses to PIH are not known. Responses to PIH induced by three cycles of 8 h hypoxia followed by 16 h normoxia were compared to those during chronic hypoxia (CH) or normoxia for 72 h in murine C2C12 and human inducible pluripotent stem cell‐derived differentiated myotubes. RNA sequencing followed by downstream analyses were complemented by experimental validation of responses that included both unique and shared perturbations in ribosomal and mitochondrial function during PIH and CH. A sarcopenic phenotype characterized by decreased myotube diameter and protein synthesis, and increased phosphorylation of eIF2α (Ser51) by eIF2α kinase, and of GCN‐2 (general controlled non‐derepressed‐2), occurred during both PIH and CH. Mitochondrial oxidative dysfunction, disrupted supercomplex assembly, lower activity of Complexes I, III, IV and V, and reduced intermediary metabolite concentrations occurred during PIH and CH. Decreased mitochondrial fission occurred during CH. Physiological relevance was established in skeletal muscle of mice with COPD that had increased phosphorylation of eIF2α, lower protein synthesis and mitochondrial oxidative dysfunction. Molecular and metabolic responses with PIH suggest an adaptive exhaustion with failure to restore homeostasis during normoxia.
STUDIES ON THE DEVELOPMENT OF SOME STRATEGIES FOR SWEET CHERRY TREE PLANTING DISTANCE AND MANAGEMENT

This papers presents the growth and fruiting of the Valerii Chkalov, Record, Ferrovia, Kordia, Regina, Stella, Skeena, Bigarreau Burlat, Lapins, Early Star, Samba and Black Star varieties, grafted on the Cerasus mahaleb, L. , MaxMa 14 and Gisela-6 rootstocks in different combinations and planted at different distances, which are grown in the southern and central area of the Republic of Moldova have been investigated. The sweet cherry trees with an age between 9 to 14 years that had been grafted on Cerasus mahaleb, L. showed a stronger growth as compared to the trees with an age between 4 to 10 years that had been grafted on Gisela 6, and the tees with an age between 8 to 10 years which had been grafted on MaxMa 14. High vigour trees are grown on non-irrigated soils; the sweet cherry trees, grafted on Gisela 6 and MaxMa 14 rootstocks are grown on fertile well-irrigated soils. The studied associations of varieties and rootstocks turned out to be suitable for cultivation in terms of the soil and climatic conditions of the area.
Synchronverters With Fast Current Loops

Virtual synchronous machines (VSMs) are inverters that behave toward the power-grid-like synchronous generators. Hence, they can be used as grid-forming inverters, and they can support the grid with inertia, droops, fault ride-through, and more. Synchronverters are a much studied type of VSMs. In this article, we present several improvements and innovations to the synchronverter control algorithm. We offer a complete design procedure for this algorithm. One change is meant to mitigate the fact that earlier designs are very sensitive to grid voltage measurement errors and processing delay, which may cause harmonic distortion and fluctuating amplitude of the grid-side currents. We propose to include a fast current controller as the internal control loop of the inverter. The design of this current controller involves delicate issues of compensating the delays and eliminating the dc components of the currents. The new design also enables a natural way for distortionless current limitation. We present a smooth start-up procedure. Our simulations and experiments show that the current controller leads to a dramatic reduction of the sensitivity of the VSM to measurement errors, processing delay, and grid voltage imbalance
Association between Demographic Factors Parental Oral Health Knowledge and their Influences on the Dietary and Oral Hygiene Practices followed by Parents in Children of 2–6 Years in Buraidah City Saudi Arabia: A Pilot Study

Abstract Background Preschool children's oral hygiene maintenance is greatly prejudiced by their parent's knowledge and understanding regarding oral health. When parents are devoid of the basic awareness of caries-associated factors, the significance of primary teeth, and oral healthcare, it is challenging to program disease prevention strategies and apply them effectively. Aims and objectives This pilot study aimed to assess the knowledge regarding oral health, its effects, and the influence of demographic values on the parental practices among the parents of 2–6-year-old children by using a self-administered pretested questionnaire. Materials and methods The questionnaire was randomly distributed among parents of 2–6-year-old children who visited Buraidah Central Hospital. The sample size taken for this pilot study was 1,000. The questionnaire included 26 questions associated with the parent's knowledge about the oral health of the child, hygiene maintenance, and dietary habits. The collected data was analyzed using SPSS software. Results In the present research, a total of 1,000 parents participated in the study. It was observed that parental knowledge and hygiene practices increased as the educational status increased. It was also observed that as the number of children decreased in the family, the dietary practices and hygiene practices improved. All these observations were found to be statistically significant (p < 0.05). Conclusion Parent's education and knowledge reflect in their child's development of healthy practices. Thus the parents need to know about oral health, which can be put into practice in their children. Clinical significance This research helps us to understand the significance of parental knowledge and education in the oral health practices and maintenance among the children inculcated by parents, which can help in bringing down the oral health diseases in children in future. How to cite this article Al Mejmaj DI, Nimbeni SB, Alrashidi RM. Association between Demographic Factors Parental Oral Health Knowledge and their Influences on the Dietary and Oral Hygiene Practices followed by Parents in Children of 2–6 Years in Buraidah City Saudi Arabia: A Pilot Study. Int J Clin Pediatr Dent 2022;15(4):407-411.
Clear Cell Sarcoma of the Kidney (CCSK) With BCOR-CCNB3 Fusion: A Rare Case Report With a Brief Review of the Literature

Pediatric renal tumors are a rare entity and majority of these tumors are accounted for by Wilms tumor. The second most common renal tumor is clear cell sarcoma of the kidney (CSSK). Most of the CSSK have either BCOR-internal tandem duplication (ITD) or YWHAE-NUTM2B/E fusion. The sarcomas with BCOR-CCNB3 fusion are well documented in soft tissue and bone tumors, but are extremely rare in the pediatric renal setting. We are reporting an extremely rare case of pediatric clear cell sarcoma of the kidney (CSSK) with BCOR-CCNB3 fusion, which was a diagnostic challenge on morphological grounds. A final diagnosis could only be reached after multiple reviews and NGS based RNA fusion testing. We have also performed a brief review of literature which revealed eight (8) other cases of this rare entity.
A Conservative Difference Scheme for the Zakharov Equations

A new conservative difference scheme is presented for the periodic initial-value problem of Zakharov equations. The scheme can be implicit or semi-explicit, depending on the choice of a parameter. The discretization of the initial condition is of second-order accuracy, which is consistent with the accuracy of the scheme. On the basis of a priori estimates and an inequality about norms, convergence of the difference solutions is proved in the energy norm. Numerical experiments with the schemes are done for several test cases. Computational results demonstrate that the new semi-explicit scheme with a new initial approximation is more accurate and computationally efficient.
Program for Simulation and Testing of Application GUI Configuration Terminal of Device Switch

Nowadays on network management, it is important for the process of managing and operating an information network. In this paper, we simulate and test a Switch Device’s Graphic User Interface (GUI) configuration terminal application in preparation for resolving the user time-consuming setup problems for a long time. The Graphic User Interface (GUI) for configuration device Switch can help reduce time and workflow by using the keypad to use various configuring commands without having to type the command itself to reduce the problem of using too long time. The program will send commands to the device switch. If the user wants to use additional commands can add the more command in this program. The program can be divided into 3 parts as follows: 1) working on the main page 2) working on the Tool page 3) working on the Show page. The result of this program can be used to configuration terminal of the device switch in real use and reduces the hassle for configuring terminal of the device switch. Someone who would like to use this simulation program, they must have the knowledge about computer network such as set IP address, configuration terminal of the equipment in the network and etc., In the instruction set of configuration terminal in this program only depended on Cisco Certified Network Associate (CCNA) by Cisco Switch.
Exercise‐induced bronchoconstriction is associated with air humidity and particulate matter concentration in preschool children

Long‐term exposure to air pollution is connected to asthma morbidity in children. Exercise‐induced bronchoconstriction (EIB) is common in asthma, and the free running test outdoors is an important method for diagnosing asthma in children. It is not known whether momentary air pollution exposure affects the results of outdoor exercise tests in children.
Impact of the number of retrieved oocytes on IVF outcomes: oocyte maturation, fertilization, embryo quality and implantation rate

Summary The process of oocyte retrieval represents a key phase during the cycles of in vitro fertilization (IVF). It involves controlled ovarian stimulation to retrieve the highest number of oocytes possible. According to many previous studies, the higher the number of oocytes the higher the chances of obtaining embryos for multiple transfers. In this study, in total, 1987 patients were retrospectively reviewed to investigate the correlations between the number of retrieved oocytes and the subsequent IVF outcomes. Patients were divided into three groups according to the number of retrieved oocytes (Group 1: ≤5 oocytes; Group 2: 6–15 oocytes; Group 3: ≥15 oocytes). The results showed a significant negative correlation between oocyte number and maturation rate as well as fertilization rate. However, a significant positive correlation was found between oocyte number and the blastulation rate. The implantation rate after fresh embryo transfers was higher in group 2 (6–15 oocytes) compared with group 1 (≤5 oocytes). According to our findings, we conclude that oocyte numbers between 6 and 15 oocytes can result in the highest chances of positive IVF outcomes in terms of embryo quality and fresh embryo transfers with lower risks of ovarian hyperstimulation.
A brief measure of guilt and shame: validation of the Guilt and Shame Questionnaire (GSQ-8)

ABSTRACT Background: Guilt and shame regulate basic human processes such as social cognition and relations. Both emotions are also involved in the aetiology and maintenance of trauma-related mental disorders such as posttraumatic stress disorder (PTSD). However, a concise scale that adequately captures these constructs is currently lacking, impeding research efforts to understand them more thoroughly. Objective: To this end, we developed the eight-item Guilt and Shame Questionnaire (GSQ-8) in English, German, and Dutch. Method: We examined the reliability and validity of the GSQ-8 in a clinical sample of adults seeking treatment for childhood-trauma-related posttraumatic stress disorder (n = 209), a sample of adults who had suffered at least one traumatic life event reporting different levels of PTSD symptoms (n = 556), and a non-clinical sample of adults (n = 156). Results: Theory-driven confirmatory factor analyses confirmed two correlated latent factors guilt and shame with four items for each factor. Across all samples, two-factor models yielded better model fit than one-factor solutions. Measurement invariance across the three samples, gender, and Dutch and German language was mostly established. Guilt and shame composite scores were associated with PTSD symptoms, depressive symptoms, life satisfaction, mental health-related quality of life, and self-blame, thus supporting scale validity. Importantly, both subscales predicted PTSD symptoms, depression, life satisfaction, and mental health-related quality of life over and above cognitions of self-blame. Conclusions: The GSQ-8 is a parsimonious, reliable, and valid tool to assess guilt and shame in clinical, sub-clinical, and non-clinical populations, allowing applications across a broad range of research questions. HIGHLIGHTS We present the 8-item Guilt and Shame Questionnaire (GSQ-8), a parsimonious tool to assess guilt and shame. We found strong psychometric properties of the GSQ-8 across three samples and different languages. The GSQ-8 can be reliably used to assess shame and guilt in clinical and non-clinical work.
Cognate RNA-Binding Modes by the Alternative-Splicing Regulator MBNL1 Inferred from Molecular Dynamics

The muscleblind-like protein family (MBNL) plays a prominent role in the regulation of alternative splicing. Consequently, the loss of MBNL function resulting from sequestration by RNA hairpins triggers the development of a neuromuscular disease called myotonic dystrophy (DM). Despite the sequence and structural similarities between the four zinc-finger domains that form MBNL1, recent studies have revealed that the four binding domains have differentiated splicing activity. The dynamic behaviors of MBNL1 ZnFs were simulated using conventional molecular dynamics (cMD) and steered molecular dynamics (sMD) simulations of a structural model of MBNL1 protein to provide insights into the binding selectivity of the four zinc-finger (ZnF) domains toward the GpC steps in YGCY RNA sequence. In accordance with previous studies, our results suggest that both global and local residue fluctuations on each domain have great impacts on triggering alternative splicing, indicating that local motions in RNA-binding domains could modulate their affinity and specificity. In addition, all four ZnF domains provide a distinct RNA-binding environment in terms of structural sampling and mobility that may be involved in the differentiated MBNL1 splicing events reported in the literature.
First chromosome scale genomes of ithomiine butterflies (Nymphalidae: Ithomiini): Comparative models for mimicry genetic studies

The ithomiine butterflies (Nymphalidae: Danainae) represent the largest known radiation of Müllerian mimetic butterflies. They dominate by number the mimetic butterfly communities, which include species such as the iconic neotropical Heliconius genus. Recent studies on the ecology and genetics of speciation in Ithomiini have suggested that sexual pheromones, colour pattern and perhaps hostplant could drive reproductive isolation. However, no reference genome was available for Ithomiini, which has hindered further exploration on the genetic architecture of these candidate traits, and more generally on the genomic patterns of divergence. Here, we generated high‐quality, chromosome‐scale genome assemblies for two Melinaea species, M. marsaeus and M. menophilus, and a draft genome of the species Ithomia salapia. We obtained genomes with a size ranging from 396 to 503 Mb across the three species and scaffold N50 of 40.5 and 23.2 Mb for the two chromosome‐scale assemblies. Using collinearity analyses we identified massive rearrangements between the two closely related Melinaea species. An annotation of transposable elements and gene content was performed, as well as a specialist annotation to target chemosensory genes, which is crucial for host plant detection and mate recognition in mimetic species. A comparative genomic approach revealed independent gene expansions in ithomiines and particularly in gustatory receptor genes. These first three genomes of ithomiine mimetic butterflies constitute a valuable addition and a welcome comparison to existing biological models such as Heliconius, and will enable further understanding of the mechanisms of adaptation in butterflies.
The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease

Parkinson’s disease is a chronic, progressive, and neurodegenerative disease, and yet with an imprecise etiopathogenesis. Although neuroinflammation was initially thought to be a secondary condition, it is now believed that microglia-induced inflammation could also contribute to the degeneration of the nigrostriatal pathway. Here, we aimed to establish the feasibility of basic inflammatory biomarkers as prognostic factors in PD. The study was based on retrospective analyses of blood samples taken from patients diagnosed with PD, as well as from healthy subjects. Complete medical records, total leukocyte count with subpopulations, and erythrocyte sedimentation rate (ESR) were analyzed. We calculated the serum neutrophils-to-lymphocytes ratio (NLR) and platelet-to lymphocytes ratio (PLR), and also compared the laboratory data between the PD group and the control group. Only PLR and NLR showed statistically significant differences (p < 0.001 and 0.04, respectively). In our study, ESR did not show statistically significant correlations with motor score or with disability. In our research, ESR was correlated with the disease duration (p = 0.04), and PLR showed a significant correlation with disease stage (p = 0.027) and disease duration (p = 0.001), but not with motor state. These biomarkers could prove to be effective tools for a primary evaluation of inflammation in PD, but further tests are required to properly investigate the neuroinflammatory status of these patients.