Miracle-dz/UniFAR-FTUs huggingface dataset:
ASIC Design of Low Area RSA Crypto-core based on Montgomery Multiplier

Background/Objectives : Currently, the most popular public key encryption is RSA. We present a low area hardware design of RSA crypto-core based on the Montgomery algorithm in ASIC. Methods : We employed Carry Save Adder in the design of the multiplier which plays a critical role in the overall design. The proposed hardware was designed at Register Transfer Level using Verilog description language with Xilinx 14.3 ISE design suite and simulated with ModelSim. In ASIC implementation, TSMC 90nm and 130nm CMOS technology was employed for synthesis of the Montgomery multiplier and modular exponentiation respectively. Findings : The primal operation of RSA cryptosystem is modular exponentiation, computed by repetitions of modular multiplications. Fast modular multiplication algorithms over the years have been proposed to speed up exponentiation and yet maximize performance. The core of this paper evolved from the modification of the modified Montgomery multiplication algorithm. From the new algorithm, a hardware architecture which simplifies the operation of the Q_logic coupled with a compact two-level CSA in the Montgomery multiplier is designed. The simplified Q_logic design and the elimination of traditional BRFA and bypass circuitry accounted for a reduction in area. Furthermore, the new multiplier is applied in the H-algorithm to develop the modular exponentiation unit. Other relevant modules in the RSA crypto-core including the pseudorandom number generator, primality tester and key generator have been optimized for resource sharing to balance and improve speed and area of the system. Synthesis results of the proposed multiplier and exponentiation unit achieved a gate count of 60K and 79K representing a reduction of 47% and 28% respectively. Improvement/Applications : Our system is suitable for low area RSA applications. Future works on this paper will examine the analysis and design of Carry Save Adder to improve propagation delay.
An enhanced dynamic Gaussian mixture model–based damage monitoring method of aircraft structures under environmental and operational conditions

Gaussian mixture model–based structural health monitoring methods have been studied in recent years to improve the reliability of damage monitoring under environmental and operational conditions. However, most of these methods only use the ordinary expectation maximization algorithm to construct the Gaussian mixture model but the expectation maximization algorithm can easily lead to a local optimal solution and a singular solution, which also results in unreliable and unstable damage monitoring especially for complex structures. This article proposes an enhanced dynamic Gaussian mixture model–based damage monitoring method. First, an enhanced Gaussian mixture model constructing algorithm based on a Gaussian mixture model merge-split operation and a singularity inhibition mechanism is developed to keep the stability of the Gaussian mixture model and to obtain a unique optimal solution. Then, a probability similarity–based damage detection index is proposed to realize a normalized and general damage detection. The method combined with guided wave structural health monitoring technique is validated by the hole-edge cracks monitoring of an aluminum plate and a real aircraft wing spar. The results indicate that the method is efficient to improve the reliability and the stability of damage detection under fatigue load and varying structural boundary conditions. The method is simple and reliable regarding aviation application. It is a data-driven statistical method which is model-independent and less experience-dependent. It can be used by combining with different kinds of structural health monitoring techniques.
OP-GTHE210327 1..15

Little is known about the genetic architecture of antifungal immunity in natural populations. Using two population genetic approaches, quantitative trait locus (QTL) mapping and evolve and resequence (E&R), we explored D. melanogaster immune defense against infection with the fungus Beauveria bassiana. The immune defense was highly variable both in the recombinant inbred lines from the Drosophila Synthetic Population Resource used for our QTL mapping and in the synthetic outbred populations used in our E&R study. Survivorship of infection improved dramatically over just 10 generations in the E&R study, and continued to increase for an additional nine generations, revealing a trade-off with uninfected longevity. Populations selected for increased defense against B. bassiana evolved cross resistance to a second, distinct B. bassiana strain but not to bacterial pathogens. The QTL mapping study revealed that sexual dimorphism in defense depends on host genotype, and the E&R study indicated that sexual dimorphism also depends on the specific pathogen to which the host is exposed. Both the QTL mapping and E&R experiments generated lists of potentially causal candidate genes, although these lists were nonoverlapping.
Cells and Increases Generation of Effector Stimulation Changes Properties of CD8 T IL-12 Priming during In Vitro Antigenic

Antigenic and costimulatory signals trigger a developmental program by which naive CD8 T cells differentiate into effector and memory cells. However, initial cytokine signals that regulate the generation of effector and memory CD8 T cells are not well understood. In this study, we show that IL-12 priming during in vitro antigenic stimulation results in the signiﬁcant increase of both primary and memory CD8 T cell population in mice after adoptive transfer of activated cells. The effect of IL-12 priming is closely associated with qualitative changes in CD8 T cells, such as reduced MHC I tetramer binding and CD69 expression, altered distribution of lipid rafts, decreased cytolytic activity, and less susceptibility to apoptosis. Furthermore, exogenous IL-12 priming improved the intrinsic survival properties of memory CD8 T cells, leading to better protective immunity and vaccine-induced memory CD8 T cell responses. However, the experiments with IL-12p40- and IL-12R (cid:1) 1-deﬁcient mice showed similar levels of primary and memory CD8 T cell responses compared with wild-type mice, implying that endogenous IL-12 and/or IL-12R signaling in vivo is not critical for CD8 T cell immunity. Together, our results suggest that IL-12 can serve as an important, but dispensable regulatory factor for the development of CD8 T cells, and IL-12 priming could be useful in many medical applications. The Journal of Immunology, 2004, 172: 2818–2826. in complete RPMI 1640 medium supplemented with 10% FCS, 2 mM of L -glutamine, 50 (cid:2) M 2-ME, 100 U/ml penicillin, and streptomycin. In neutralization experiments, these cul-tures were treated with 10 (cid:2) g/ml anti-IL-2, anti-IFN- (cid:3) , or anti-TNF- (cid:4) neutralizing mAb to block the potential activities of endogenous sources of these cytokines. At 2 days after in vitro activation, live lymphocytes were isolated by Ficoll-Hypaque (Amersham Pharmacia Biotech, Uppsala, Swe-den) density-gradient centrifugation, and then puriﬁed by negative selec- tion using MACS. In brief, cells were incubated with mAb-conjugated magnetic beads for CD4 (for OT-I) or CD8 (for OT-II), MHC II, B220, CD11b, and CD11c, followed by depletion of positive cells using LS (cid:2) MACS columns (Miltenyi Biotec), and then adoptively transferred into normal C57BL/6 mice (2 (cid:3) 10 6 cells/mouse in 200 (cid:2) l of PBS). For Ab stimulation, MACS-puriﬁed cells were stimulated for 2 days with plate- bound anti-CD3 (300 ng/well) and anti-CD28 mAb (100 ng/well). For assessing the cell type dependency of IL-12, MACS-puriﬁed naive OT-I or IL-12R (cid:1) 1-deﬁcient OT-I cells were mixed with indicated syngenic APCs as stimulator cells puriﬁed from LN and spleen of normal C57BL/6 or IL-12R (cid:1) 1-deﬁcient mice by MACS-positive selection using anti-MHC II, anti-B220, anti-CD11b, and anti-CD11c microbeads.
The Effect of Sample Amount and Decoction Time on The Phytochemicals and Antioxidant Activities of Decoction Lemon Balm and Sage

: cennet.yaman@bozok.edu. tr ABSTRACT In this study, decoctions (herbal tea) of sage (Salvia officinalis L.) and lemon balm (Melissa officinalis L), two of the important medicinal plants, were analysed for antioxidant activity, antioxidants, and minerals (K, Na, Mg, Ca, Fe, Ba, Ag and Ga) were determined in each sage and lemon balm dry leaves as well as decoctions by inductively coupled plasma-mass spectrometry (ICP-MS). The antioxidant activities of decoctions were evaluated by scavenging activities against 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and hydrogen peroxide (H 2 O 2 ) radicals, and varied from 19.4 to 109.1 mg trolox equivalent (TE) cup -1 for DPPH and from 35.0 to 168.0 mg ascorbic acid equivalent (AAE) cup -1 for H 2 O 2 . The highest antioxidant activity and antioxidants such as total phenolic, flavonoid and flavanol contents were found in the decoction of lemon balm. The analysed minerals were most efficiently observed in sage decoctions. The study also showed that the best sample amount in terms of the minerals was 3 g for both species, but decoction time was statistically insignificant for sage and 10 min more effective for lemon balm. As a result, it was tried to determine the most appropriate sample amount and decoction time for the decoctions of both species according to the
NSA_A_257392 61..76

1Université Paris Saclay, CNRS UMR 8214, Institut des Sciences Moléculaires d’Orsay, 91405 Orsay, France; 2Cátedra CONACyT, Faculty of Chemical Sciences, Autonomous University of San Luis Potosí, 78210 San Luis Potosí, Mexico; 3Université Paris Saclay, CNRS UMR 8182, Institut de Chimie Moléculaire et des Matériaux d’Orsay, 91405 Orsay, France; 4Paris-Saclay University, Multimodal Imaging Center (UMS 2016/ US 43) CNRS, INSERM, Institut Curie, 91405 Orsay, France; 5Department of Charged Particle Therapy Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 263-8555 Chiba, Japan; 6Université Paris Saclay, CNRS UMR 8000, Institut de Chimie Physique, 91405 Orsay, France Purpose: Metal-based nanoparticles (M-NPs) have attracted great attention in nanomedicine
PERVASIVENESS OF IRON DEFICIENCY IN THALASSEMIA TRAIT IN PAKISTAN

: Introduction: Thalassemia is considered the most common genetic disease in the world, and about 7% of the world's population are carriers. The vast majority of such cases are iron deficient. Aim: This study was undertaken to identify patterns of iron levels in the features of thalassemia, and thus to identify coexisting iron deficiency. Method: This cross-sectional study was conducted at the Department of Medicine Unit-II of Services Hospital Lahore for one-year duration from June 2019 to May 2020. Adult anemia patients with hypochromic microcytic smear presenting to the outpatient clinic were screened for thalassemia based on clinical history, physical symptoms, and hemoglobin electrophoresis. A total of 50 anemia patients with thalassemia carriers were detected and selected for iron profile evaluation. Results: Patients with iron deficiency detected on the basis of serum iron profile were compared with patients without iron deficiency. The mean age in the studied years was 30.38 ± 9.79 years. Among the studied population, 50% were men and 50% women. The highest incidence of coexisting iron deficiency was found in people aged 21-30 years. The frequency of iron deficiency among the b-type thalassemia trait was 30.2%. There was a statistically significant mean difference in Hb, MCV, MCH, MCHC, serum iron, TIBC, and S. saturation ferritin, indicating that subjects without iron deficiency had higher levels than subjects without iron deficiency (p <0.05). Conclusion: Clinical iron deficiency may occur in people with thalassemia disease / in carriers of hereditary hemoglobin disorders. A complex condition should always be suspected, and iron supplements are often needed to improve the anemia condition.
S Density and Speed of Sound of Sodium Nitroprusside with Aqueous Alcohols

TUDIES on apparent molar volumes for the solutions of sodium sodi nitroprusside in aqueous solutions of methanol, ethanol and propanol in the temperature range 298.15 to 313K at 5K intervals have been determined from the density measurements of the solutions. Speed of sound of solutions of sodium nitroprusside in aqueous solutions of alcohols has also been experimentally determined at 303.15K. Molar isentropic compressibilities and apparent molar isentropic compressibilities have been calculated from the speed of sound data. These results have been used to calculate the following partial molar quantities :  0 sK Various acoustic parameters and solvation number have been evaluated for sodium nitroprusside in different aqueous solutions of alcohols. The results are discussed in the light of solute- solvent and
Sparse Gaussian Process Emulators for Surrogate Design Modelling

Efficient surrogate modelling of computer models (herein defined as simulators) becomes of increasing importance as more complex simulators and non-deterministic methods, such as Monte Carlo simulations, are utilised. This is especially true in large multidimensional design spaces. In order for these technologies to be feasible in an early design stage context, the surrogate model (oremulator) must create an accurate prediction of the simulator in the proposed design space. Gaussian Processes (GPs) are a powerful non-parametric Bayesian approach that can be used as emulators. The probabilistic framework means that predictive distributions are inferred, providing an understanding of the uncertainty introduced by replacing the simulator with an emulator, known as code uncertainty. An issue with GPs is that they have a computational complexity of O(N3) (where N is the number of data points), which can be reduced to O(NM2) by using various sparse approximations, calculated from a subset of inducing points (where M is the number of inducing points). This paper explores the use of sparse Gaussian process emulators as a computationally efficient method for creating surrogate models of structural dynamics simulators. Discussions on the performance of these methods are presented along with comments regarding key applications to the early design stage.
Safety and efficacy of dialyzer reuse by manual reprocessing: an observational study

Background: Haemodialysis is the main form of RRT in the patients of CKD. Haemodialysis is a costly procedure and is not afforded by many. Reuse of components of Haemodialysis circuit helps in reducing cost but may be associated with decreased efficacy and side effects.Methods: Prospective observational study. Manual reprocessing of dialyzer was done with either formaldehyde or peracetic acid. Single brand (Fresenius) dialyzer were used across all patients. Dialysis efficacy was calculated by URR and side effect and toxicity monitored in a predefined proforma.Results: A total 50 patients were studied (39 male and 11 female) with age ranging from 31-60 years. The mean urea reduction ratio after four dialysis session with the same dialyzer was 62.93% which is below KDOQI recommendation. The findings in our study suggest that URR was adequate upto three session of haemodialysis by reprocessed dialyzer but not beyond that. The choice of chemical for reprocessing did not affect the efficacy. As compared to F6 dialyze F8 dialyzer had better initial URR and this was maintained upto fourth reuse. Serum albumin levels correlated with the fall in efficacy of dialyzers. There were no significant complications of reuse of dialyzers across both methods of reprocessing and there was no dialyzer first use syndrome.Conclusions: ESRD affects a younger age group in our country. Use of large membrane area results in better efficacy. Dialyzer reuse with manual reprocessing is safe and also effective upto third and fourth use. Dialyzer reuse is associated with economic benefits.
and Disease in a Murine Model of Lupus MyD88-Dependent Autoantibody Production TLR9 Regulates TLR7- and

Systemic lupus erythematosus is characterized by the production of autoantibodies against nucleic acid-associated Ags. We previously found that Tlr7 was required for anti-Sm and Tlr9 for anti-chromatin autoantibodies. Yet, although Tlr7 deﬁciency ameliorated disease, Tlr9 deﬁciency exacerbated it. Despite the mechanistic and clinical implications of this ﬁnding, it has yet to be elucidated. In this study, we characterize MRL/lpr lupus-prone mice genetically deﬁcient in Tlr7, Tlr9, both Tlr7 and Tlr9, or Myd88 to test whether Tlr7 and Tlr9 function independently or instead regulate each other. We ﬁnd that disease that is regulated by Tlr9 (and hence is worse in its absence) depends on Tlr7 for its manifestation. In addition, although Tlr7 and Tlr9 act in parallel pathways on different subsets of autoantibodies, Tlr9 also suppresses the production of Tlr7-dependent RNA-associated autoantibodies, suggesting previously unrecognized cross-regulation of autoantibody production as well. By comparing disease in mice deﬁcient for Tlr7 and/or Tlr9 to those lacking Myd88, we also identify aspects of disease that have Tlr- and Myd88-independent components. These results suggest new models for how Tlr9 regulates and Tlr7 enhances disease and provide insight into aspects of autoimmune disease that are, and are not, inﬂuenced by TLR signals. The Journal of Immunology , 2010, 184: 1840–1848. T TLRs are a family of cell surface or endosomal pattern
Algorithm for Virtual Aggregates’ Reconstitution Based on Image Processing and Discrete-Element Modeling

Based on the Aggregate Imaging Measurement System (AIMS) and the Particle Flow Code in Two Dimensions (PFC2D), an algorithm for modeling two-dimensional virtual aggregates was proposed in this study. To develop the virtual particles precisely, the realistic shapes of the aggregates were captured by the AIMS firstly. The shape images were then processed, and the morphological characteristics of aggregates were quantified by the angularity index. By dividing the particle irregular shape into many triangle areas and adjusting the positions of the generated balls via coordinate systems’ conversion within PFC2D, the virtual particles could be reconstructed accurately. By calculating the mapping area, the gradations in two-dimensions could be determined. Controlled by two variables (μ_1 and μ_2), which were drawn from the uniform distribution (0, 1), the virtual particles forming the specimens could be developed with random sizes and angular shapes. In the end, the rebuilt model of the SMA-13 aggregate skeleton was verified by the virtual penetration tests. The results indicated that the proposed algorithm can not only model the realistic particle shape and gradations precisely, but also predict its mechanical behavior well.
Spatial-Temporal Variation of Snow Black Carbon Concentration in Snow Cover in Northeast China from 2001 to 2016 Based on Remote Sensing

: The amount of black carbon (BC) on snow surface can signiﬁcantly reduce snow surface albedo in the visible-light range and change the surface radiative forcing effect. Therefore, it is key to study regional and global climate changes to understand the BC concentration on snow. In this study, we simulated the BC concentration on the surface snow of northeast China using an asymptotic radiative transfer model. From 2001 to 2016, the BC concentration showed no signiﬁcant increase, with an average increase of 82.104 ng/g compared with that in the early 21st century. The concentration of BC in December was the largest (1344.588 ng/g) and decreased in January and February (1248.619 ng/g and 983.635 ng/g, respectively). The high black carbon content centers were concentrated in the eastern and central regions with dense populations and concentrated industries, with a concentration above 1200 ng/g, while the BC concentration in the southwest region with less human activities was the lowest (below 850 ng/g), which indicates that human activities played an important role in snow BC pollution. Notably, Heilongjiang province has the highest concentration, which may be related to its atmospheric stability in winter. These ﬁndings suggest that the BC pollution in northeast China has been aggravated from 2001 to 2016. It is estimated that the snow surface albedo will decrease by 16.448% due to the BC pollution of snow in northeast China. The problem of radiative forcing caused by black carbon to snow reﬂectivity cannot be ignored.
Exploitation of Biostimulants as an Alternative Strategy to Control Bacterial Rot Diseases of Onion ( Allium cepa L.)

acterial soft rots, commonly caused by Erwinia carotovora subsp. carotovora or Erwinia chrysanthemi , and slippery skin, caused by Burkholderia gladioli subsp. allicola as well as sour skin, caused by Burkholderia cepacia of onion bulbs are among the most serious storage diseases of onion ( Allium cepa L.) that lead to great loss in bulbs. In this study some biostimulants; chitosan, seaweed extract and humic acid were in vivo tested on onion plants, to determine their controlling potential against bacterial rot diseases. Application of biostimulants proved to be effective in reducing the bacterial rot in stored onion bulbs. All tested biostimulants increased photosynthetic pigments content in onion leaves and total phenols content in onion bulbs, meanwhile they declined lipid peroxidation and the electrolyte leakage percentage in onion bulbs. As a summary, chitosan, seaweed extract and humic acid could be applied to improve plant growth and stimulate plant defense against diseases in concern. These materials are cheap, available, easy to apply, hazardless and environmentally safe.
HSOA Journal of Vaccines Research & Vaccination Correlation between Virulence Genes Profile of Currently Circulating E. coli Pathotypes Isolated from Diarrheic Calves and Humans

Correlation between Virulence Genes Profile of Currently Circulating E. coli Pathotypes Isolated from Diarrheic Calves and Humans. J Vaccines Res Vaccin 5: 009. Abstract Introduction: Diseases causing diarrhea are one of the major causes of deaths in low and middle income countries and responsible for high mortality rate in young calves resulting in economic losses. Several studies concluded to the high distribution of Escherichia coli ( E. coli ) strains in infectious calf diarrhea. STEC causes human gastrointestinal illnesses with diverse clinical spectra. So this study was planned for isolation, identification and molecular characterization of the currently circulating E. coli between calves and related workers in Egypt and to determine the role of virulence genes and pathotypes of E. coli in diarrhea in both calves and humans. Material and methods: A total of 161 Holsteins calves with varying ages in four different farms in Egypt were examined clinically for diarrhea as well as related human workers in these farms. 43 fresh fecal samples were collected from diarrheic calves as well as 18 stool swab samples from workers then transferred to microbiological laboratory for bacteriological and molecular examination. Results: The prevalence rate of E. coli was 53% among diarrheic calf samples and the highest isolation rate was 77% among Group I (age <month) and decreased with age. Meanwhile isolation rate in human samples was 50% (9 out of 18). Regarding virulence genes, VT1 , VT2 and eaeA virulence gens were successfully amplified in 1, 7 and 7 out of 23 calf isolates respectively. On the other hand human isolates showed only positive reaction with VT1 and VT2 were recovered from 5 and 4 out of 9 isolates while eaeA gave no positive reaction. Conclusion: Depending on the virulence gene profiling of E. coli isolates, there was 8 out 23 animal isolates were Shiga Toxin producing E. coli (STEC) representing 35% of total animal isolates and 7 out of 23 animal isolates were Enteropathogenic E. coli (EPEC) representing 30% of total animal isolates. Meanwhile, 100% of the human isolates were STEC.