Miracle-dz/UniFAR-FTUs huggingface dataset:
Programmed Death 1 (PD-1) Expression in Relapsing and Remitting Hodgkin Lymphoma as Prognostic Factor

Background: Programmed death ligand 1 (PD-L1) plays critical role in PD-1-dependent immunity suppress. Abnormal PD-L1 expression has shown to be directly related to poor prognosis and drug resistance in cancer patients. Hence, we aimed to evaluate PD-L1 expression in relapsing and remitting Hodgkin lymphoma (HL) as a prognostic factor. Methods: In this cross-sectional study, 100 patients with HL between 2007 and 2015, were included. A thin section of tumor tissue fixed and processed on slides, stained by immunohistochemistry (IHC) PD-L1 specific antibodies. The clinical, imaging and pathology information of patients were obtained using case reading and by retrospective follow-up. The status of recurrence or improvement was determined after 5 years of diagnosis. GraphPad Prism v.8 was used for analysis. Results: of 100 HL cases, the mean age of 33 relapsed group cases was significantly higher than remission group (p-value = 0.006), and gender was not significant however majority of cases in both groups were male. The frequency of PD-L1 expression found in 49% of all patients. A significant relationship was found between the expression of PD-L1 and disease progression, HL subtype, stage of tumor (p-value<0.05). High expression of PD-L1 found in majority of relapse group and low expression in remission group. Conclusion: PD-L1 expression assessment in HL patients is a valuable tool for prediction of the disease subtype, progression, stage, and treatment outcome. IHC method as an available, simple, rather cheap, and efficient tool could use for evaluation of PD-L1 expression and predicting the prognosis of HL disease, elsewhere.
Redefinición estratigráfica del grupo Río Chico (Paleógeno Inferior), en el norte de la cuenca del golfo San Jorge, Chubut

El Grupo Rio Chico (Paleoceno Superior-Eoceno Medio), de origen continental y aflorante en la cuenca del Golfo San Jorge,aun no cuenta con un esquema litoestratigrafico adecuado que contemple las variaciones y relaciones espaciales de sus unidadesintegrantes. En este trabajo, restringido arealmente al norte de la cuenca, se redefinen sus cuatro formaciones que de basea techo son: Las Violetas, Penas Coloradas, Las Flores y Koluel-Kaike. La relacion inferior del grupo con la FormacionSalamanca es de tipo transicional y se resuelve en un intervalo estratigrafico denominado en este trabajo niveles transicionales.La Formacion Las Violetas se circunscribe al centro del area de estudio, borde norte de la cuenca, donde se manifiesta unaposible relacion de lateralidad con la Formacion Penas Coloradas. Esta ultima muestra un importante desarrollo en la zonacostera y occidental, sin aflorar en el area central de estudio. La Formacion Las Flores alcanza su mayor espesor en la zonacentral (facies mas gruesas) y disminuye hacia el este y oeste (facies mas finas). La Formacion Koluel-Kaike posee sus faciestipicas y mayores espesores hacia el oeste, mientras que hacia el centro y este se acuna hasta desaparecer en el borde norte dela cuenca. La relacion superior de esta ultima unidad con la suprayacente Formacion Sarmiento es de tipo transicional
DEP Domain-Containing Protein 1B (DEPDC1B) Promotes Migration and Invasion in Pancreatic Cancer Through the Rac1/PAK1-LIMK1-Co ﬁ lin1 Signaling Pathway

Background: With increasing incidence, pancreatic cancer (PC) is one of the most common digestive tract tumors. However, the prognosis of PC is particularly dismal due to the highly invasive and metastatic behavior of this deadly disease. DEP domain-containing protein 1B (DEPDC1B), which is overexpressed in multiple tumors, such as breast cancer, oral cancer and non-small cell lung cancer, plays a signi ﬁ cant role in cell movement, cell cycle and cytoskeleton reorganization. However, the function of DEPDC1B in PC remains poorly understood. Methods: The function of DEPDC1B in the migration and invasion of PC was evaluated by wound healing and Transwell assays in vitro and PC-derived liver metastasis models in vivo. were investigated through cell line establishment, Western blotting, qRT-PCR, immunoprecipitation, histological examination and immunohistochemistry analysis. Results: DEPDC1B was overexpressed in PC cell lines. DEPDC1B regulated cell migration and invasion. DEPDC1B regulated the Rac1/PAK1-LIMK1-co ﬁ lin1 signaling pathway by interacting with Rac1. Rac1 inhibition suppressed DEPDC1B-induced migration and invasion in PC in vitro and DEPDC1B-induced liver metastasis in vivo. Conclusion: DEPDC1B promoted cell migration and invasion by activating the Rac1/ PAK1-LIMK1-co ﬁ lin1 signaling pathway, thus providing a potential therapeutic target against PC.
NUTRITIONAL STATUS OF CHILDREN AND ADOLESCENTS: FACTORS ASSOCIATED TO OVERWEIGHT AND FAT ACCUMULATION

Objective: To estimate prevalence and identify factors associated with the nutritional status of individuals aged 8 to 17 years old in schools located at 3 administrative regions in the city of Vitoria, Brazil. Methods: The nutritional status of 400 students was assessed based on a cross-sectional study. Association between overweight and fat accumulation around waist was tested considering the variables: sexual maturaten stage, income level, number of siblings, maternal Body Mass Index (BMI) and physical activity. Individuals considered stunting had height-for-age 25kg/m 2 , and high income level. Fat accumulation around the waist was associated to the following variables: maternal BMI >25kg/m 2 , high income level, age 28 hours/week. Conclusions : Low prevalence of nutritional deficits and high prevalence of overweight and fat accumulation around the waist were found. Higher prevalence rate occurred among individuals showing the following characteristics: higher income level; overweight mother; within initial and intermediate stages of sexual maturation; bellow 14 years old; sedentary.
Orthostatic hypotension and dementia incidence: links and implications

: Orthostatic hypotension (OH) is a common condition, particularly in patients with α -synucleinopathies such as Parkinson ’ s disease, and has a signi ﬁ cant impact on activities of daily living and quality of life. Recent data suggest an association with cognitive impairment. Herein, we review the evidence that OH increases the odds of incident mild cognitive impairment and dementia. Potential mechanisms underlying the putative relationship are discussed, including cerebral hypoperfusion, supine hypertension, white matter hyperintensities, and neurodegeneration. Finally, we highlight the challenges with respect to treatment and the negative impact on the quality of life and long-term prognosis presented by the coexistence of OH and dementia. Large population-based studies have reported that OH is associated with about a 20% increased risk of dementia in the general population, while smaller cohort studies suggest an even greater effect in patients with α -synucleinopa-thies (3- to 7-fold higher than controls). Ultimately, OH exposure is dif ﬁ cult to quantify, predominantly limited to pressure regulation during a one-time orthostatic challenge, and the causative association with dementia may turn out to be bidirectional, especially in α synucleinopathies. Early diagnosis and treatment of OH may improve long-term prognosis.
Predicting lithium treatment response in bipolar patients using gender-specific gene expression biomarkers and machine learning [version 3; peer review: 1 approved, 2 approved with reservations]

Background: We sought to test the hypothesis that transcriptomelevel gene signatures are differentially expressed between male and female bipolar patients, prior to lithium treatment, in a patient cohort who later were clinically classified as lithium treatment responders. Methods: Gene expression study data was obtained from the Lithium Treatment-Moderate dose Use Study data accessed from the National Center for Biotechnology Information’s Gene Expression Omnibus via accession number GSE4548. Differential gene expression analysis was conducted using the Linear Models for Microarray and RNA-Seq (limma) package and the Decision Tree and Random Forest machine learning algorithms in R. Results: Using quantitative gene expression values reported from patient blood samples, the RBPMS2 and LILRA5 genes classify male lithium responders with an area under the receiver operator characteristic curve (AUROC) of 0.92 and the ABRACL, FHL3, and NBPF14 genes classify female lithium responders AUROC of 1. A Decision Tree rule for establishing male versus female samples, using gene expression values were found to be: if RPS4Y1 ≥ 9.643, patient is a male and if RPS4Y1 < 9.643, patient is female with a probability=100%. Conclusions: We developed a pre-treatment genderand geneexpression-based predictive model selective for classifying male lithium responders with a sensitivity of 96% using 2-genes and female lithium responders with sensitivity=92% using 3-genes. Open Peer Review
The Relation between Information and Heterogeneous Ability in Joint Projects - An experimental Analysis -

We study voluntary contribution behavior of individuals who vary in their ability to contribute to a joint project under different information scenarios. We investigate a situation with two types who vary only in their external marginal return (low and high). Results of a laboratory experiment suggest that, when group members are not aware of the heterogeneity in their group, both types make the same nominal contributions. When agents are informed about the heterogeneity, contributions increase but differently by type. High types contribute only more with sufficient social exposure, i.e., when information on the type of the contributor is available. Low types, on the other hand, contribute only more when they are aware of the distribution of types, but have no information on the type of the contributor.
Chemosensory event-related potentials in alcoholism: A specific impairment for olfactory function.

Olfactory abilities are crucial in the development and maintenance of alcoholism, but while they have been widely explored in other psychiatric states, little is known concerning this sensorial modality among alcoholics. The present study explored the brain correlates of the olfaction deficit in alcoholism. Ten alcoholics and ten matched controls took part in psychophysical and electrophysiological olfactory testing. At behavioural level, we showed odor identification deficits in alcoholism, for orthonasal and retronasal testing. Electrophysiological data showed abnormalities (in latency and amplitude) for N1 and P2 olfactory components among alcoholics, which constitutes the first description of the cerebral correlates of olfactory impairments in alcoholism. This deficit appears associated with alterations in the brain structures responsible for the secondary, “cognitive” processing of odors. These results underline the need to take into account olfactory deficits in clinical practice and in studies exploring brain correlates of craving by means of alcohol odors. © 2011 Elsevier B.V. All rights reserved.
Assessing the variability and predictability of adipokines (adiponectin, leptin and resistin and their ratios) in non-obese and obese women with polycystic ovary syndrome

Objectives To assess the variability in adiponectin, leptin, and resistin between ovulatory women, and non-obese and obese women with polycystic ovary syndrome (PCOS). The study also explores the ratios of the adipokines and evaluated their predictability for PCOS. Results The PCOS group presented with lower adiponectin [13.0(10.49-16.59) vs 18.42(15.72-19.92) µg/ml, p<0.0001], adiponectin: leptin ratio [0.60(0.35-0.88) vs 1.19(0.92-1.37), p<0.0001], and adiponectin: resistin ratio [0.30(0.21-0.43) vs 0.42(0.32-0.62), p<0.0001] but a higher leptin [20.02(14.54-26.80) vs 16.17(14.51-18.36) ng/ml, p<0.0001] and leptin: resistin ratio [0.53(0.37-0.82) vs 0.40(0.27-0.48), p<0.0001] compared to the ovulatory group. The obese PCOS group presented with lower adiponectin [11.04(5.66-13.25) vs 14.18(11.04-18.02) µg/ml, p<0.0001 and 18.42(15.72-19.92) µg/ml, p<0.0001], adiponectin: leptin ratio [0.36(0.27-0.44) vs 0.78(0.61-1.16), p<0.0001 and 1.19(0.92-1.37), p<0.0001], and adiponectin: resistin ratio [0.24(0.17-0.38) vs 0.40(0.23-0.58), p<0.0001 and 0.42(0.32-0.62), p<0.0001] but a higher leptin [26.80(14.28-32.09) vs 17.95(14.86-21.26) ng/ml, p<0.05 and 16.17(14.51-18.36) ng/ml, p<0.0001] and leptin: resistin ratio [0.63(0.46-1.03) vs 0.41(0.30-0.61), p<0.0001 and 0.40(0.27-0.48), p<0.0001] compared to the non-obese PCOS and ovulatory control group, respectively. Adiponectin: leptin ratio presented with the best discriminatory power in predicting PCOS (AUC=0.83) followed by adiponectin alone (AUC=0.79), and leptin: resistin ratio and leptin alone (both AUC=0.69). Resistin alone presented with the poorest discriminatory power (AUC=0.48). This study shows signi�cantly altered serum levels adiponectin and leptin but not resistin in Ghanaian women with PCOS compared to healthy subjects. Obese PCOS patients have the most altered levels of adipokines compared to non-obese PCOS and healthy subjects. Adiponectin: leptin ratio is the best predictor of PCOS compared to individual adipokines.
Spread of P. ramorum from nurseries into waterways-implications for pathogen establishment in new areas

In the United States, water and soil baiting have been part of the U.S. Department of Agriculture, Animal and Plant Health Inspection Service (USDA APHIS) Confirmed Nursery Protocol (CNP) to prevent the spread of Phytophthora ramorum from infected nursery stock since 2005. Additionally, the U.S. Department of Agriculture, Forest Service (USDA FS) has, since 2006, supported the national early detection stream baiting survey of forests and urban areas to monitor the potential spread of this pathogen from nurseries and other high-risk settings. These surveys have been conducted in cooperation with universities and state forestry agencies. As a result of these activities, P. ramorum has been detected in waterways at 10 sites in six states between 2006 and June 2009 (fig. 1). Below is a brief overview of these positive sites. Florida - In 2006 and 2007, P. ramorum was recovered from standing and flowing water inside, but not outside, a retail garden center where P. ramorum-positive plants were present. In February 2008, P. ramorum was recovered from a drainage ditch at a nearby production nursery that was associated with the garden center site. Then, in December 2008 and again in March 2009, the pathogen was detected in bait leaves deployed in a stream outside this nursery. Mississippi – P. ramorum was baited from a drainage ditch outside a nursery in December 2007. Subsequently, it was recovered from this ditch several times in 2008 and 2009 and a creek into which the ditch drains (using PCR on bait leaves) on multiple occasions from January 2008 through early 2009. Streamside vegetation surveys outside of the nursery resulted in PCR positives on two APHIS official host and associated host plant (HAP) (http://www.aphis.usda.gov/plant_health/plant_pest_info/pram/) samples in December 2007 and February 2008. To date, this is the only site where streamside vegetation surveys have detected P. ramorum on vegetation samples.
Dach1 inhibits glioma invasion and tumor growth via the Wnt/catenin pathway

Background/aim: Glioma is the most common and malignant nervous system tumor and is associated with high-grade malignancy and high recurrence. The mammalian Dachshund1 (DACH1) is a recognized anti-tumor site and has low expression in several malignant tumors, including glioma. We designed and conducted this study to further determine the mechanism of DACH1 in glioma. Patients and methods: The data collected from specimens of patients with glioma from GSE16011 and REMBRANDT databases were analyzed. The effect of DACH1 on proliferation, migration, and invasion of U87 and U251 cell lines was analyzed in vitro. The symbol targets of the Wnt/ β -catenin pathway were also evaluated through Western blot. Results: DACH1 deficiency was found in glioma tissues, and the DACH1 level was negatively correlated with the tumor malignancy. DACH1 overexpression inhibited the tumor proliferation, migration, and invasion. High expression of DACH1 also dampened the Wnt/ β -catenin pathway, and the activation of the Wnt/ β -catenin pathway partly led to the limited proliferation in glioma cells. Conclusion: Downregulation of DACH1 was related to the malignancy and poor prognosis of patients with glioma, and DACH1 overexpression inhibited the tumor proliferation via the Wnt/ β -catenin pathway. These findings might assist in the discovery of novel potential diagnostic and therapeutic targets for DACH1, thereby reducing the malignancy and recurrence of glioma.
Escherichia coli Sequence Type 131 Lineage C1-M27 Clone in Clinical Isolates, Germany

We examined extended-spectrum β -lactamase–produc-ing isolates from livestock, humans, companion animals, and the during 2009–2016 in for the presence of CTX-M-27 allele within Escherichia coli Angiostrongylus cantonensis , the rat lungworm, is the most common infectious cause of eosinophilic meningoencephalitis worldwide. This parasite is endemic to Southeast Asia and the Pacific Islands, and its global distribution is increasing. We report A. cantonensis meningoencephalitis in a 12-month-old boy in Tennessee, USA, who had not traveled outside of southwestern Tennessee or northwestern Mississippi.
Technology Medicine

Recently, many studies concerning probiotics, prebiotics, and biogenics have been performed, whereas only a few are related to the stomach (about 2% as publication number). In this chapter, we focus on recent studies on probiotics, prebiotics, and biogenics for the stomach and also describe our recent research on a novel strain of lactobacillus beneficial to stomach, Lactobacillus johnsonii No.1088 (LJ88). As probiotics for the stomach, some beneficial strains were summarized, and underlying mechanisms of anti- Helicobacter pylori activity were discussed. Prebiotics for the stomach were considered as a future potential target, since no indigenous bacteria beneficial to the stomach have been found to date. As biogenics, some plant-derived candidates were discussed. In this context, recent results on LJ88 lactobacillus were presented. Orally administered LJ88 inhibited H. pylori growth and the increase in the number of gastrin-producing cells, which side effect is caused by triple therapy for H. pylori . LJ88 had no resistance to typical antibiot‐ ics, and both living and heat-killed forms of it increased the number of bifidobacteria among human intestinal-microbiota in mice. These results suggest that LJ88 is a lactobacillus beneficial to both stomach and intestine as a probiotic and biogenic.
Control of soft robots with inertial dynamics

Soft robots promise improved safety and capability over rigid robots when deployed near humans or in complex, delicate, and dynamic environments. However, infinite degrees of freedom and the potential for highly nonlinear dynamics severely complicate their modeling and control. Analytical and machine learning methodologies have been applied to model soft robots but with constraints: quasi-static motions, quasi-linear deflections, or both. Here, we advance the modeling and control of soft robots into the inertial, nonlinear regime. We controlled motions of a soft, continuum arm with velocities 10 times larger and accelerations 40 times larger than those of previous work and did so for high-deflection shapes with more than 110° of curvature. We leveraged a data-driven learning approach for modeling, based on Koopman operator theory, and we introduce the concept of the static Koopman operator as a pregain term in optimal control. Our approach is rapid, requiring less than 5 min of training; is computationally low cost, requiring as little as 0.5 s to build the model; and is design agnostic, learning and accurately controlling two morphologically different soft robots. This work advances rapid modeling and control for soft robots from the realm of quasi-static to inertial, laying the groundwork for the next generation of compliant and highly dynamic robots. Description Data-driven modeling and control of soft robot arms enable previously inaccessible results in inertial and nonlinear regimes.
Deep Learning for Irregularly and Regularly Missing 3-D Data Reconstruction

Physical and/or economic constraints cause acquired seismic data to be incomplete; however, complete data are required for many subsequent seismic processing procedures. Data reconstruction is a crucial and long-standing topic in the exploration seismology field. We extended our previous works on deep learning (DL)-based irregularly and regularly missing 2-D data reconstruction to 3-D data. A key motivation is that the 3-D convolutional neural network (CNN) can take full advantage of the 3-D nature of the data, and the additional dimension allows more information to contribute to the data reconstruction. DL also avoids many assumptions (e.g., linearity, sparsity, and low-rank) limiting conventional nonintelligent reconstruction methods. We built an artificial neural network (ANN) based on an end-to-end U-Net encoder–decoder-style 3-D CNN. The ANN was trained on large quantities of various synthetic and field 3-D seismic data using a mean-squared-error (MSE) loss function and an Adam optimizer. We demonstrated that the developed 3-D CNN reconstruction method appears to outperform the 2-D CNN for 3-D restoration. We benchmarked the ANN’s generalization capacity for recovery of irregularly and regularly sampled 3-D data on several typical seismic data sets, particularly those with high missing percentages or large gaps. An ANN trained with irregularly sampled data can be partly applied to regularly sampled cases. We investigated how a key parameter, i.e., the learning rate, can be experimentally determined. In the context of the presented examples, our methodology provided a substantial improvement over an open-source state-of-the-art rank-reduction-based approach in terms of data fidelity and efficiency.
THE INFLUENCE OF COLD IN PROPRIOCEPTION OF THE NORMAL KNEE JOINT

The objective of this study was to determine whether the therapeutic use of cold, affects proprioception when applied to the knee joint. Cryotherapy decreases sensory and motor nerve conduction velocities, which are necessary for a normal proprioceptive acuity. Normal proprioceptive acuity is necessary in order to avoid injuries of the musculoskelectal system. Sixty-four healthy volunteers, aged 18-25, moderately active men and women were recruited from a large sample of University students. Subjects were randomly assigned to either the control or the experimental group. The subjects of the experimental group were subjected to 20 min of temperature at constant (5oC), with an ice application to the knee joint. The results showed that cold does not affect the joint position sense in a normal knee.