Miracle-dz/UniFAR-FTUs huggingface dataset:
Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells

Chikungunya virus (CHIKV) is the causative agent of the human disease chikungunya fever, characterized by debilitating acute and chronic arthralgia. No licensed vaccines or antivirals are currently available for CHIKV. Therefore, the prevention of attachment of viral particles to host cells is a potential intervention strategy. As an arbovirus, CHIKV infects a wide variety of cells in both its mammalian and mosquito host. This broad cell tropism might stem from CHIKV’s ability to bind to a variety of entry factors in the host cell including phosphatidylserine receptors (PSRs), glycosaminoglycans (GAGs), and the proteinaceous receptor Mxra8, among others. In this study, we aimed to determine the relevance of each attachment factor during CHIKV entry into a panel of mammalian and mosquito cells. Our data suggest that the importance of particular binding factors during CHIKV infection is highly cell line dependent. Entry into mammalian Vero cells was mediated through attachment to PSRs, mainly T-cell immunoglobulin mucin domain-1 (TIM-1). Conversely, CHIKV infection into HAP1 and NIH3T3 was predominantly mediated by heparan sulfate (HS) and Mxra8, respectively. Entry into mosquito cells was independent of PSRs, HS, and Mxra8. Although entry into mosquito cells remains unclear, our data denotes the importance of careful evaluation of reagents used to identify receptor use in invertebrate cells. While PSRs, GAGs, and Mxra8 all enhance entry in a cell line dependent manner, none of these factors are necessary for CHIKV entry, suggesting additional host factors are involved.
Clinical Aspects and Precipitating Factors of Hepatic Encephalopathy Associated with Cirrhosis in a Cameroonian Population

Background: Hepatic Encephalopathy (HE), a common complication of cirrhosis, is associated with a pejorative prognosis. This study aims to describe the clinical presentation, precipitating factors and outcome of HE. Methods: This was a cross-sectional multicenter inpatient study in cirrhotic patients admitted for HE in four tertiary hospitals in Yaounde (Cameroon) from December 2016 to May 2017. The diagnosis of HE was based on West Haven clinical criteria. The diagnosis of cirrhosis was made using clinical and/or biological, endoscopic and/or ultrasonography signs. Results: A total of 53 patients with HE (mean age: 49.9 ± 18.9 years, 35 Males) were included. The frequency of hospital admission for HE was 4.9%. HE grade III was the most common (37.7%), followed by grades I and II (26.4% and 26.4%, respectively). Grade IV was present in 9.4% of cases. According to the Child-Pugh score, 72.1% of the patients were at stage C and 27.9% at stage B. The main precipitating factors found were: constipation (38.5%), hyponatremia (35.9%), hepatocellular carcinoma (HCC) (31.7%), herbal medicine (28.3%), hypokalemia (25.6%), gastrointestinal bleeding (22.6%) and ascitic fluid infection (spontaneous bacterial peritonitis) (13.8%). In 5.7% of cases, no factor was identified. Mortality rate during hospitalization was 45.3% and was significantly associated with stage III (RR = 11.1; 95% CI: 1.9 - 64.5; p = 0.003) and IV (RR = 24; 95% CI: 1.6 - 40.9; p = 0.01) of HE; Child-Pugh C score (RR = 15.2; 95% CI: 1.7 - 30.1; p = 0.003) and hypokalemia (RR = 12.2; 95% CI: 1.3 - 19; p = 0.01). Conclusion: HE is a common complication during cirrhosis with a poor prognosis. In the majority of cases, a precipitating factor could be determined.
“Maintaining the image of a desired teacher”: major issues of late-career senior teacher educators

ABSTRACT This narrative study explores the late-career issues among 15 senior teacher educators from Israeli Academic Colleges of Education (ACEs), in light of the growing conversation about pre-pension maintenance of senior faculty members employed in teacher education institutions. The data analysis of semi-structured interviews highlighted dedication to daily tasks (research activity, administration, teacher education and leading Professional Learning Communities), and a sense of mission during career experiences (leaving legacy to student teachers and colleagues). It was reflected in two parallel work patterns: the ‘work pattern of sharing’, and the ‘work pattern of expertise’. The discussion raises similarities between the literature and the first work pattern, in line with the unique culture of teacher education systems in the world. However, the existence of the ‘work pattern of expertise’ in the literature remains vague and requires more in-depth thinking and research.
Neogene Corylopsis seeds from eastern Tennessee

A new fossil species of Corylopsis (Hamamelidaceae), C. grisea Quirk & Hermsen sp. nov, based on seeds from the early Pliocene Gray Fossil Site (GFS), eastern Tennessee, USA, is described. The assignment of the seeds to Hamamelidaceae, subfamily Hamamelidoideae, is based on the overall size of the seeds, smooth testa, lack of a seed wing, and the presence of a terminal hilar scar. The assignment to the genus Corylopsis is based on seed size as well as the presence of a hilar facet, in addition to the hilar scar. Although Corylopsis persists only in East Asia today, its fossil record indicates that the genus was widespread across the Northern Hemisphere in the past. Prior to its discovery at GFS, Corylopsis was only known from the Paleogene in North America. The presence of C. grisea at GFS extends the fossil record of Corylopsis in North America to the Neogene and reinforces the interpretation of GFS as a forested refugium that provided a relatively moist, equable environment where subtropical to warm temperate plants could persist during a time of cooling and drying in the continental interior of North America. Its presence provides additional evidence for the biogeographic connection between the GFS paleoflora and the modern flora of eastern Asia.
The Role of Skeletal Survey in Identifying Non-Accidental Trauma in Pediatric Trauma Patients

Background: Non-accidental Trauma (NAT) is a major cause of morbidity and mortality in children. Children less than 2 years old are at greater risk of NAT than older children. A skeletal survey is a series of X-rays of all the bones in the body, or at least the axial skeleton and the large cortical bones used to identify NAT in children. In this observational study, we examined the association between a child’s age, frequency of positive skeletal surveys, and the types of injuries discovered in pediatric patients undergoing a trauma work-up. Methods: The study sample consisted of all pediatric trauma patients ≤3 years old who had skeletal surveys performed at a single tertiary care center in Central Massachusetts between 2005 and 2015. Patients were divided into two age groups: ≤6months old (n=98) and >6months old (n=86). The utilization of a skeletal survey, frequency of confirmed NAT, and injuries were compared between these 2 age groups. Results : The average age of the sample was 8.4 months, 56.0% were boys, and 62.5% were Caucasian. A positive skeletal survey was found in 14.3% of patients ≤6months old and 18.6% of patients >6months old (p=0.43). The most common fractures identified were long bone (50.0%), torso (30.4%), and skull (13.0%). Similar frequencies of NAT were observed between those less than and older than 6 months (58.2% vs. 57.0%). Head computed tomography (CT) scans were performed in the majority (95.9%) of patients ≤6 months old while in only 66.3% of patients > 6 months old (p Conclusions: Skeletal surveys identify injuries at comparable rates in pediatric trauma patients regardless of age. Advanced imaging differs in younger and older pediatric trauma patients undergoing skeletal survey.
REVERIE: Remote Embodied Visual Referring Expression in Real Indoor Environments

One of the long-term challenges of robotics is to enable robots to interact with humans in the visual world via natural language, as humans are visual animals that communicate through language. Overcoming this challenge requires the ability to perform a wide variety of complex tasks in response to multifarious instructions from humans. In the hope that it might drive progress towards more flexible and powerful human interactions with robots, we propose a dataset of varied and complex robot tasks, described in natural language, in terms of objects visible in a large set of real images. Given an instruction, success requires navigating through a previously-unseen environment to identify an object. This represents a practical challenge, but one that closely reflects one of the core visual problems in robotics. Several state-of-the-art vision-and-language navigation, and referring-expression models are tested to verify the difficulty of this new task, but none of them show promising results because there are many fundamental differences between our task and previous ones. A novel Interactive Navigator-Pointer model is also proposed that provides a strong baseline on the task. The proposed model especially achieves the best performance on the unseen test split, but still leaves substantial room for improvement compared to the human performance. Repository: https://github.com/YuankaiQi/REVERIE.
Foreign Body of External Auditory Canal: Review of 170 Cases

Received May 10, 2017 Revised July 23, 2017 Accepted July 26, 2017 Address for correspondence Sung Il Nam, MD, PhD Department of Otorhinolaryngology, School of Medicine, Keimyung University, 56 Dalseong-ro, Jung-gu, Daegu 41931, Korea Tel +82-53-250-7159 Fax +82-53-256-0325 E-mail entnamsi@dsmc.or. kr Background and ObjectivesZZForeign bodies in the external auditory canal (EAC) are frequently encountered by otolaryngologists, emergency care physicians and pediatricians. The purpose of this study was to assess clinical characteristics, complications, as well as to investigate the proper management of foreign bodies in the EAC. Subjects and MethodZZWe retrospectively reviewed and analyzed clinical records of patients who presented with foreign bodies in the EAC at the otolaryngologic department of Keimyung University Dongsan Hospital from January, 2011 to October, 2016. ResultsZZOne-hundred seventy patients with aural foreign bodies were identified. The age of patients ranged from 12 months to 83 years, with 34.1% of the patients being under 10 years of age. Thirteen different types of foreign bodies were found, where insects, cottons and beads were the most common. Approximately 98% of the foreign bodies were removed without general anesthesia by using proper instruments under direct vision. Complications were observed in 5.8% of the patients: these included laceration and bleeding from the EAC (80%) and traumatic perforation of the tympanic membrane (20%). ConclusionZZVarious methods are available for foreign body removal from the EAC. In order to remove foreign bodies successfully and reduce complications, patients should be given precautions, such as, regarding adequate immobilization, prior to removing foreign bodies using proper instruments with a surgical microscope under appropriate anesthesia. Korean J Otorhinolaryngol-Head Neck Surg 2017;60(12):599-604
Effect of home visits by community health workers on complementary feeding practices among caregivers of children aged 6–23 months in 10 districts of Bangladesh

Background Suboptimal complementary feeding contributes to undernutrition in children aged 6–23 months in low- and middle-income countries like Bangladesh. Multifaceted interventions have been taken to improve complementary feeding practices, but there is limited evidence about the effect of home visits by community health workers (CHWs) on complementary feeding practices of the caregivers of children. Methods We collated data from the baseline and the corresponding follow-up survey done as part of an evaluation of Bangladesh Maternal, Infant and Young Child Nutrition (MIYCN) programme. We collected data on complementary feeding practices using a 24-h recall questionnaire. Age-appropriate dietary diversity, minimum meal frequency, and minimum acceptable diet were assessed based on recommended food consumption as per child's age. To understand the effect of CHWs' visits on complementary feeding practices, we performed Generalized Estimating Equation (GEE) procedure for dealing with correlated data and adjusted other covariates. Results A total of 758 and 745 caregivers of children aged 6–23 months participated in the baseline and follow-up survey, respectively. Complementary feeding practices were improved in 1 year of programme implementation; dietary diversity increased from 46 to 54%, minimum meal frequency from 82 to 91%, and minimum acceptable diet from 41 to 53%. Caregivers of children who had received the visit of CHWs in the last 12 months prior to the day of the follow-up survey were more likely (AOR 1.51; 95% CI 1.10–2.10) to maintain dietary diversity in their children's feeding practices than the caregivers who had not received a CHW visit in the last 12 months. The likelihood of maintaining a minimum acceptable diet in feeding practices was 1.57 times higher (AOR 1.57; 95% CI 1.14–2.17) among the caregivers who were exposed to the visits of the CHWs in the last 12 months compared to the caregivers who were not exposed to the CHW's visits in the last 12 months. Conclusion Integration of promotional activities of complementary feeding practices into the mainstream nutrition programme can be instrumental in optimizing complementary feeding practices among the caregivers of the under-five children. However, home visits by CHWs should be prioritized in such an integrated programme.
Immunotherapy and tumor mutational burden in cancer patients with liver metastases: A meta and real word cohort analysis

Background The predictive effects of liver metastases for immune-checkpoint inhibitors (ICIs) and the relationship between tumor mutational burden (TMB) and liver metastases (LM) remain unclear. Methods A systematic review and meta-analysis were conducted to explore the heterogeneity of ICIs efficacy between patients with or without LM. A pan-cancer cohort of 1,661 patients who received ICIs was downloaded and analyzed to assess the association between TMB and LM. Results Of 21053 studies identified in our search, eight single-arm studies and 24 randomized controlled trials were included. Overall, 17957 patients with advanced or metastatic cancers (4805 patients (26.8%) with LM and 13151 patients (73.2%) without LM) were enrolled. The pooled objective response rate (ORR) was 8.5% (95% CI 4%–13%) in the LM group versus 21% (95% CI 16%–21%) in the non-LM group. The pooled hazard ratio (HR) for death was 0.85 (95% CI 0.80–0.90) in the LM group treated with ICIs compared with the standard of care. In patients without LM who were treated with ICIs, the pooled HR for death was 0.78 (95% CI 0.73–0.82) compared with the standard of care. The difference in efficacy between patients with or without LM treated with ICIs was significant (p=0.04). Pan-cancer analysis revealed that the TMB-high rate was 10.8% in liver metastatic lesions versus 21.4% in other metastatic lesions (p=0.004). In addition, TMB was also significantly associated with OS as a binary cutoff (p=0.05) and was an independent prognostic variable (HR=0.98, P=0.047) as a continuous variable in patients with LM. Conclusions In patients with LM, the efficacy of immunotherapy was attenuated, but TMB-high could predict better survival outcomes.
Measuring optimal psychological states: Proposal of two brief versions to measure flow and clutch in athletes

Background The study of sports experiences with high levels of performance has led to the observation of two psychological states categorized as optimal, denominated flow and clutch. The objective of this study is to design and validate two brief scales version to measure flow and clutch. Methods Following the MIMO (Maximum Information, Minimum Discomfort) protocol, three studies are carried out: In Study 1, we developed the short versions of the questionnaires based on theory-driven and data-driven criteria; in Study 2, we used quantitative criteria to validate the short versions; and in Study 3, we checked the final version of each scale to observe their statistical validity and their relation to other variables. Results The new short flow scale is made up of seven items, while the clutch scale is made up of five items. Throughout the three studies, evidence is provided of the internal consistency, invariance of the measurement models and content validity, validity related to the responding process and validity in relation to other variables. Conclusion This study provides two short versions to evaluate flow and clutch, which will help to continue advancing in the study of optimal psychological states in sport.
Association of Anthropometric Characteristics to Static Sagittal Postural Balance Strategy in Healthy Young Adults

Background and purpose: Associations of a positive sagittal postural imbalance with pain, physical disability and reduced health-related quality of life have emerged as the predictor of clinical symptoms. Limits of postural stability in sagittal standing are set by mechanical factors that include both individual and environmental characteristics. The variability of individual anthropometric characteristics and body dimensions may be considered to affect the selection of motor strategies that people use to maintain standing balance control. The purpose of the present study is to evaluate the association of anthropometric characteristics with static sagittal postural balance strategy in healthy young adults Methodology: Total of 239 healthy under graduate collegiate students aged 18-25 years were randomly screened. Individual’s anthropometric characteristics were measured in accordance with ISAK standards. The Indices of BMI (Kg/m), upper body height to lower body height ratio (UBH/LBH ratio); waist to hip circumference ratio (WC/HC ratio); bi-acromial to bi-iliocristal width ratio (BA/BI ratio) were calculated. Static sagittal postural Balance strategy (Anterior; neutral; posterior) was analyzed using lateral postural analysis. Individual anthropometric characteristics were compared among the three types of sagittal postural balance strategy. Results: Gender specific analysis revealed that the anthropometric characteristics like weight (WT); BMI; WC; HC and BI in females are significantly associated with the shift of neutral balance strategy towards the sagittal posterior direction whereas anterior strategy, being most prevalent in both the genders is not associated with any anthropometric characteristics. Conclusions: Higher BMI; weight; biacromial width (BA); waist (WC) and hip circumference (HC) were the significant determinants of sagittal posterior balance strategy among female adults. We suggest that assessment of an individuals anthropometric characteristics and adopted sagittal standing postural strategy in clinical set up can improve the insight in designing the therapeutic strategies by directing the intervention approach towards the modifiable body characteristics.
The Relationship Between Working Environment and Employee Performance

A positive working environment is vital in ensuring employee productivity to avoid unnecessary stress to the employees thus affecting their work performances. There are several working environment factors that contributed towards job satisfaction. Hence, this study aimed to investigate the relationship between the working environment and employee performance based on five dimensions of the working environment. The quantitative survey design was utilized in this study and data were collected by using questionnaires. The respondents of this study were administrators from different departments in a local municipality located in Kuching. The data were analysed by using Pearson’s Correlation Analysis to measure the relationship between the variables. The finding shows there is a significant relationship between the working environment and employee performance. Support from supervisor was found to be the dominant variables in ensuring a positive working environment. Keywords: Working environment; Employee performance; Municipality; Human resource; Health
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN TINGKAT KECEMASAN PADA PASIEN PREOPERATIVE DI RS MITRA HUSADA PRINGSEWU

All of the nursing intervention in hospital was not certainly be positively accepted by patients. People ability has different, so that can arise the stress condition or anxiety. The prevalence of anxiety in America were more than 28%. The age who get anxiety were 9-17 years, 13% age of 18-54 years, 16% age of 55 and 11.4% of elderly. Women have risk to anxiety, two times than man. This study was to know the factors that related to anxiety level in Preoperative patient in Mitra Husada Hospital, Pringsewu, in 2016. The method of this study was a correlation with using cross sectional approach. The population were 58 respondents. Technique of sampling was using accidental sampling. Data were analyzed by univariat and bivariat using Chi square. The result showed that there were a relationship of gender, age, and economic status (p-value 0.05) with the anxiety level of Preoperative patient in Mitra Husada Hospital, Pringsewu.
Effects of acute exercise fatigue on the spatiotemporal dynamics of resting-state large-scale brain networks

Introduction Various approaches have been used to explore different aspects of the regulation of brain activity by acute exercise, but few studies have been conducted on the effects of acute exercise fatigue on large-scale brain functional networks. Therefore, the present study aimed to explore the effects of acute exercise fatigue on resting-state electroencephalogram (EEG) microstates and large-scale brain network rhythm energy. Methods The Bruce protocol was used as the experimental exercise model with a self-controlled experimental design. Thirty males performed incremental load exercise tests on treadmill until exhaustion. EEG signal acquisition was completed before and after exercise. EEG microstates and resting-state cortical rhythm techniques were used to analyze the EEG signal. Results The microstate results showed that the duration, occurrence, and contribution of Microstate C were significantly higher after exhaustive exercise (p’s < 0.01). There was a significantly lower contribution of Microstate D (p < 0.05), a significant increase in transition probabilities between Microstate A and C (p < 0.05), and a significant decrease in transition probabilities between Microstate B and D (p < 0.05). The results of EEG rhythm energy on the large-scale brain network showed that the energy in the high-frequency β band was significantly higher in the visual network (p < 0.05). Discussion Our results suggest that frequently Microstate C associated with the convexity network are important for the organism to respond to internal and external information stimuli and thus regulate motor behavior in time to protect organism integrity. The decreases in Microstate D parameters, associated with the attentional network, are an important neural mechanism explaining the decrease in attention-related cognitive or behavioral performance due to acute exercise fatigue. The high energy in the high-frequency β band on the visual network can be explained in the sense of the neural efficiency hypothesis, which indicates a decrease in neural efficiency.