Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-Administered Six-Minute Walk Test Using a Free Smartphone App in Asymptomatic Adults: Reliability and Reproducibility

Background: The 6-min walk test (6MWT) is a simple, inexpensive, reliable, and reproducible test that provides a reasonable estimate of the cardiorespiratory fitness (CRF). We aimed to assess the reliability and reproducibility of a self-administered 6MWT in asymptomatic adults using a free smartphone app. Methods: In the 1st phase, 93 participants underwent a supervised 6MWT (6MWTsup) in a 30 m indoor corridor, using a triaxial accelerometer and their smartphones to compare the total step counts and to develop a 6-min walk distance (6MWD) prediction equation. In the 2nd phase, 25 participants performed the 6MWTsup and two self-administered 6MWTs outdoors (6MWTsa1 and 6MWTsa2, at least 48 h apart) using a free smartphone app. Results: The agreement between accelerometer- and app-based total step counts was limited (mean difference, −58.7 steps (−8.7%): 95% confidence interval, −326.5 (−46.8%) to 209.1 (29.3%)). The best algorithm for predicting the 6MWTsupm included: 795.456 + (0.815 heightm app-steps) − (1.620 ageyears) − (3.005 weightkg) − (1.155 app-steps), R2 = 0.609). The intraclass correlation coefficient between 6MWTsa2 and 6MWTsa1 was excellent (0.91: 0.81–0.96). The coefficient of variation was 6.4%. The agreement between the two self-administered tests was narrow (−1.9 (0.2%) meters: −57.4 (−9.5%) to 61.3 (9.9%)). Conclusions: The self-administered 6MWT has excellent reliability and reproducibility in asymptomatic adults, being a valuable tool for assessing CRF in community-based interventions.
The impact of talent management practices on employees’ satisfaction and commitment in the Saudi Arabian oil and gas industry

This study investigates the impact of talent management practices in Saudi Arabian oil and gas organizations and assesses their impact on talent management outcomes including employees' satisfaction and commitment. Although talent management is a new concept for increasing employee on employees' satisfaction and commitment, it is rapidly becoming of great value for academics and managers. The literature review identified the gaps in TM literature; prompting the development of a framework for understanding the relationship between TM, its outcomes. A cross-sectional online-based survey was conducted with employees from major oil and gas organizations, achieving a total sample of 417 participants. Results have indicated various issues such as the need to adopt formal approaches for identifying the talent and lack of opportunities for development that exist in TM practices. Furthermore, the majority of the participants reflected poor satisfaction levels, and a lack of strong commitment was observed among the young employees. Based on the findings, it can be concluded that poor TM practices adopted in Saudi Arabian oil and gas industries in a few instances, especially in relation to talent development and retention by creating a supportive environment through transformational leadership.
Simplified method for rainwater harvesting tank sizing using long day-resolution rainfall time series

This work aims to develop a simplified method for rainwater harvesting tank sizing using long dayresolution rainfall time series. The developed method, also considers heterogeneous contributing catchments and water demand flow rates. In order to estimate the tank capacities it is proposed to take into account the probability to supply the water demand, as well as the most probable time step needed and their respective variabilities. This method was applied to a specific case study (campus of the Pontificia Universidad Javeriana, Bogota –PUJ– university rainwater harvesting tank sizing), with 73 years of daily-resolution rainfall information (between 1936 and 2010, without years 1969 and 1988 with no data). The method was applied using different time periods from data-set and the results obtained are: (i) for the whole data series - 76 years: 395 m
DAMAGE ON STANDING TREES DURING WOOD SKIDDING (WINCHING PHASE) BY CABLE SKIDDER TIMBERJACK 225 A

UDK: 630*37:630*4 Hauling of heavy and voluminous load (wood) partially through forest wastelands and partially on built roads makes this the most expensive phase, which is also technically the most challenging and most damaging for the forest eco-system. Although it is clear that the realisation of this phase in forest harvesting cannot be completed without certain forest damage, in expert and scientific circles there is general consent that by careful planning and execution in forestry, this damage can be brought down to an ‘acceptable’ level. One of the reliable indicators of stand damage is the amount of mechanical damage resulting from forest harvesting operations. This damage can be ascertained rather easily and correctly, and the environmental and economic consequences of mechanical damage of standing trees are better known than those resulting from damaging saplings or the soil. (Martinić, 2000). Pertaining to this, this paper presents the measuring and analysis of mechanical damage to standing trees as a result of hauling trees using the cable skidder ‘Timberjack 225 A’ in the forest unit 17, Management Unit ‘Gornja Stavnja’, Forest Management Company ‘Gornjebosansko’. The amount of damage was analysed, the place where it occurred on the tree, the level of damage and the surface of the inflicted damage. All the stated analyses were carried out for two ways of skidding wood using a winch (falling and ascending). Results show, among others, that the stand damage expressed in the percentage of damaged trees of the total tree count is 15.41%, which is the upper limit Martinić (1993) ascertained for this phase of forest harvesting, including the variability of working methods and techniques. Almost half of the damage is stated in the first third of the distance between the skidder path and transport boundary, with the largest amount of damage occurring on the most valuable part of the tree (butt end), especially during slope skidding.
Platelets’ Role in Dentistry: From Oral Pathology to Regenerative Potential

Platelets are a cellular subgroup of elements circulating in the bloodstream, responsible for the innate immunity and repairing processes. The diseases affecting this cellular population, depending on the degree, can vary from mild to severe conditions, which have to be taken into consideration in cases of minor dental procedures. Their secretion of growth factors made them useful in the regenerative intervention. The aim of this review is to examine the platelets from biological, examining the biogenesis of the platelets and the biological role in the inflammatory and reparative processes and clinical point of view, through the platelets’ pathology and their use as platelets concentrates in dental regenerative surgery.
Exploration of Common Sensory Interventions Utilized in School-Based Occupational Therapy

ABSTRACT Occupational therapy practitioners provide sensory-based interventions to support children as they learn academically, develop self-regulation skills, and participate in play and activities of daily living skills alongside their peers. These interventions are used both for children who have a specific sensory-related diagnosis as well as children who do not have a specific diagnosis. This study explored common occupational therapy sensory interventions utilized within the United States school settings along with implementation barriers for sensory intervention services for children ages 3–18 years old. Occupational therapy practitioners completed an electronic survey and a focus group. Results indicated that many occupational therapy practitioners frequently used sensory interventions through indirect services with children in preschool and elementary school. Occupational therapy practitioners must provide interprofessional training for education teams for effective sensory intervention implementation in school-based settings.
A Study on Laboratory Simple Shearing Test of Pile-Soil Interface

Water content of soil plays an important role in mechanism behavior of pile-soil interface.Experiments by using laboratory simple shear tests are performed on soil-concrete interfaces with 17%,20%,24%,three water contents,where five normal stresses are taken into account in each water content.The experimental data show that while water content is fixed,failure of interface still satisfies the Mohr-Coulomb criterion.With higher water content,shearing strength,friction angle of the interface all decrease monotonously and nonlinearly,but cohesion force of the interface first increases and then decreases after reaching a peak value.With water content increasing,failure position of the interface moves from concrete surface to soil inner part.The initial piece of stress-strain curve of interface is not sensitive to water content of soil.This experimental results put the good foundation for relative engineering numerical simulation.
Experimental investigation on punching shear behavior of concrete slab nonrectangular column connections

An experimental program was carried out to investigate the punching shear behavior of RC slab nonrectangular column connections. Nine specimens with typical specially shaped columns (cross shaped section, T shaped section and L shaped section) and two reference specimens with square columns were tested under central loads. The tested ultimate loads, deformations and failure modes of specimens are presented in the paper. Test results revealed that the punching shear strength and ductility of the connections with nonrectangular columns were higher than that of the corresponding connections with square columns. Based on the test results, a method for calculating punching shear strength of connections with speacially shaped columns is proposed, which conforms with the current design practice of China. The test results on the punching shear strength were compared with the predictions of the formulas proposed by codes of practice ACI 318—95, BS 8110, CEB FIP Model Code and GB 50010—2002, it was found that ACI code and China code gave conservative predictions as the reinforcement ratio was increased.
Characteristics and Outcomes of Patients With Frailty Admitted to ICU With Coronavirus Disease 2019: An Individual Patient Data Meta-Analysis

Supplemental Digital Content is available in the text. OBJECTIVES: Frailty is often used in clinical decision-making for patients with coronavirus disease 2019, yet studies have found a variable influence of frailty on outcomes in those admitted to the ICU. In this individual patient data meta-analysis, we evaluated the characteristics and outcomes across the range of frailty in patients admitted to ICU with coronavirus disease 2019. DATA SOURCES: We contacted the corresponding authors of 16 eligible studies published between December 1, 2019, and February 28, 2021, reporting on patients with confirmed coronavirus disease 2019 admitted to ICU with a documented Clinical Frailty Scale. STUDY SELECTION: Individual patient data were obtained from seven studies with documented Clinical Frailty Scale were included. We classified patients as nonfrail (Clinical Frailty Scale = 1–4) or frail (Clinical Frailty Scale = 5–8). DATA EXTRACTION: We collected patient demographics, Clinical Frailty Scale score, ICU organ supports, and clinically relevant outcomes (ICU and hospital mortality, ICU and hospital length of stays, and discharge destination). The primary outcome was hospital mortality. DATA SYNTHESIS: Of the 2,001 patients admitted to ICU, 388 (19.4%) were frail. Increasing age and Sequential Organ Failure Assessment score, Clinical Frailty Scale score greater than or equal to 4, use of mechanical ventilation, vasopressors, renal replacement therapy, and hyperlactatemia were risk factors for death in a multivariable analysis. Hospital mortality was higher in patients with frailty (65.2% vs 41.8%; p < 0.001), with adjusted mortality increasing with a rising Clinical Frailty Scale score beyond 3. Younger and nonfrail patients were more likely to receive mechanical ventilation. Patients with frailty spent less time on mechanical ventilation (median days [interquartile range], 9 [5–16] vs 11 d [6–18 d]; p = 0.012) and accounted for only 12.3% of total ICU bed days. CONCLUSIONS: Patients with frailty with coronavirus disease 2019 were commonly admitted to ICU and had greater hospital mortality but spent relatively fewer days in ICU when compared with nonfrail patients. Patients with frailty receiving mechanical ventilation were at greater risk of death than patients without frailty.
Diagnostic Value of Non-invasive Scoring Systems in the Prediction of Esophageal Varices in Patients with Liver Cirrhosis—Single Center Experience

Background and Objectives: Upper endoscopy is considered the gold standard for screening and diagnosis of esophageal varices (EV). Non-invasive methods for predicting EV have become a research hotspot in recent years. The aim of this study was to assess the role of non-invasive scores in predicting the presence of EV in patients with liver cirrhosis, and to determine the value of these scores in predicting the outcome of patients with cirrhosis presenting with acute variceal bleeding. Materials and Methods: A total of 386 patients with liver cirrhosis were included. The model for end-stage liver disease (MELD), aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT), AST to platelet ratio index (APRI), fibrosis-4-index (FIB-4), fibrosis index (FI), King’s Score, albumin-bilirubin (ALBI) score, and platelet-albumin-bilirubin (PALBI) score were calculated. The discriminatory capacities of the examined scores in predicting the presence of esophageal varices were tested using receiver operating characteristic (ROC) curves. Results: The ROC curve analysis showed (area under the curve) AUC values of ALBI and PALBI of 0.603, and 0.606, respectively, for the prediction of EV. APRI, MELD, PALBI, King’s, FIB-4, and ALBI scores showed statistically significant correlation with EV bleeding (p < 0.05). AUC of APRI and MELD for predicting EV bleeding were 0.662 and 0.637, respectively. The AUC value of MELD in short-term mortality was 0.761. Conclusions: ALBI and PALBI scores had modest diagnostic accuracy of EVs in liver cirrhosis. APRI and MELD can be used as a reference index for the EV bleeding, and MELD score is best associated with short-term outcome in cirrhotic patients.
Standard and Newly Defined Prognostic Factors Affecting Early Mortality After Hip Fractures

Purpose: Early mortality rate in geriatric patients after hip fractures remains very high. Determining the prognostic factors is crucial for decreasing early mortality. This study aimed to evaluate the prognostic risk factors affecting early mortality after hip fracture in the elderly. Methods: Medical records of 335 patients with age 70 years or older who sustained hip fractures which were treated by hemiarthroplasty or proximal femoral nailing between May 2017 and May 2019 were reviewed. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were investigated for validity as the new prognostic markers. The other variables included age, gender, type of surgery, type of implant, type of anesthesia, American Society of Anesthesiologists (ASA) score, presence of comorbidities, delirium, length of hospital stay, time delay to surgery, number of erythrocyte transfusions, and laboratory data were assessed for 30-day, 90-day, and one-year mortality. Univariate analysis and logistic regression analysis were used to determine the associated mortality. Results: Thirty-day mortality rate was 10.4% and was associated with being aged ≥90 years (p-value: 0.013, odds ratio {OR}: 0.13) and ASA score of 4 (p-value: 0.019, OR: 0.22). Ninety-day mortality rate was 21.5% and was associated with age (p-value: 0.002), being aged 80-89 years (p-value: 0.032, OR: 0.43), being aged ≥90 years (p-value: 0.001, OR: 0.13), general anesthesia (p-value: 0.016, OR: 0.41), preoperative high NLR level (p-value: 0.028, OR: 1.05), high blood urea nitrogen (BUN) level (p-value: 0.049, OR:1.02). One year mortality rate was 33.7% and independent significant prognostic risk factors were determined as being aged ≥90 years (p-value: 0.003, OR: 0.23), length of hospital stay (p-value: 0.003, OR: 1.04), and preoperative serum albumin level (p-value: 0.037, OR: 0.6). The other evaluated risk factors were not independently found to be associated with all early mortality time. Conclusion: Patients at or over 90 years old were at risk for all early mortality time points. NLR which is a new and cheap biomarker can be used as a prognostic risk factor for 90-day mortality. The variable of PLR was not found valuable for early mortality.
Temporal features of non-accident critical events impact from tides around the Yangtze Estuary and adjacent coastal waters

Abstract Applying non-accident critical events (NACEs) as an alternative measuring method to assess ship collision risk has become popular in recent years. NACEs has shown temporal features in different waters. This study uses the quaternion ship domain method to identify NACEs around the Yangtze Estuary and adjacent coastal waters from the Automatic Identification System (AIS) data in October 2019. The results indicate that NACEs show different temporal features in estuaries and coastal waters. The relationship between tides, channel types and ships is discussed. In addition, we established a statistical method for the occurrence time of NACEs and the state of tides according to the half-tide level and the nearest time. The outcomes of this study provide a direction for exploring the relationship between NACEs and environmental conditions, which is also instructive for the study of the causes of ship accidents.
HER2+ Breast Cancer Escalation and De-Escalation Trial Design: Potential Role of Intrinsic Subtyping

Simple Summary Classical clinical research has been developed according to immunohistochemical breast cancer subtypes, instead of designing trials specifically for each molecular subtype. Efforts in de-escalating treatment should focus on identifying a subgroup of HER2 oncogene addicted tumours that are especially sensitive to anti-HER2 therapies and, thus, spare unnecessary treatments. A prognostic assay that integrates molecular tumour features with clinical and pathologic variables and accurately defines a group of HER2 addicted tumours remains the best candidate among these strategies. Abstract Long-term outcomes in breast cancer patients differ based on the molecular subtype, with HER2-E being the most aggressive one. Advances in clinical practice have dramatically shifted HER2+ breast cancer prognosis. Risk adapted strategies to individualize therapies are necessary. De-escalation approaches have been encouraged based on the risks of clinical-pathological factors. Molecular gene subtyping could further accurately define HER2 addicted tumours that are sensitive to anti-HER2 therapies, thus sparing unnecessary treatments. The transition from immunochemistry to molecular profiling in HER2+ breast cancer is discussed.
A Hybrid Simulation Model for Characterization of Nonlinear Circuits Using Harmonic Radar

A realistic simulation model to obtain harmonic power curves of nonlinear circuits using harmonic radar is proposed in this study. Advanced Design System (ADS) and High Frequency Structural Simulator (HFSS) are used as simulation tools. HFSS is used for modelling free space radiation and ADS is used for circuit modelling. Three different circuits are modelled in ADS which are diode clamper, diode limiter and full wave rectifier. In HFSS part of the simulation, wideband Vivaldi antennas are modelled as radar transmit and receive antennas. To couple radiated power on electronic circuits, a single opportunity dipole antenna tuned to radar transmit frequency is used. Similarly to reradiate the harmonics generated by electronic circuits back to the radar, a log periodic dipole antenna is modelled as an opportunity transmit antenna. Sweeping electromagnetic power level from 0 to 40 dBm on the transmit antenna, nonlinear variation of reflected harmonic powers due to nonlinear components are observed.
Calciphylaxis Cutis Associated With Fibroblast Growth Factor Receptor (FGFR) Inhibitor Therapy: A New Challenge

Specific fibroblast growth factor receptor (FGFR) inhibitors have been developed to treat malignancies harboring fusions or rearrangements in FGFR2 or FGFR3. Here, we report a case of calciphylaxis cutis in association with FGFR inhibitor therapy in a patient with FGFR2 rearranged cholangiocarcinoma. Although calciphylaxis cutis typically arises in the setting of hyperphosphatemia and end-stage renal disease, this patient had preserved renal function, normal serum calcium, and only modestly elevated serum phosphorus levels, which is similar to other recent reports of calciphylaxis in patients receiving FGFR inhibitor therapy. Calciphylaxis cutis is a possible adverse event observed with FGFR inhibitor therapy, and the mechanism of calciphylaxis cutis in association with FGFR inhibitor therapy warrants further investigation.
Cold Tolerance is Governed by Diverse Genetic Mechanisms Including Those Regulated by NB-LRR-type Receptor Proteins in Arabidopsis

Cold stress adversely affects the growth and development of plants and limits the geographical distribution of crop plants. Accumulation of spontaneous mutations shapes the adaptation of plant species to diverse climatic conditions. Genome-wide association study of the phenotypic variation gathered by a newly designed phenomic platform with that of the single nucleotide polymorphic (SNP) loci across the genomes of 417 Arabidopsis natural variants collected from various geographical regions revealed 33 candidate genes for cold tolerance. Investigation of at least two independent mutants for 29 of these genes identified 16 cold tolerance genes controlling diverse genetic mechanisms. This study identified five genes encoding novel leucine-rich repeat domain-containing proteins, including three nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins. Among the 16 identified cold tolerance genes, ADS2 and ACD6 are the only two cold tolerance genes identified earlier. The comparatively little overlap between the genes identified in this genome-wide association study of natural variants with those discovered previously through forward and reverse genetic approaches suggests that cold tolerance is a complex physiological process governed by a large number of genetic mechanisms. Short Summary Cold stress adversely affects the growth and development of plants and limits the geographical distribution of crop plants. Genome-wide association study of the phenotypic variation of Arabidopsis natural variants with that of the single nucleotide polymorphic loci followed by T-DNA insertion mutant analyses of 29 candidate genes led to assigning cold tolerance function for the first time to 14 genes including three nucleotide-binding sites leucine repeat region (NB-LRR) protein genes. The comparatively little overlap between the genes identified in this study with those discovered previously suggests that cold tolerance is governed by a complex network of multiple genetic mechanisms.