Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnostic Accuracy for Periprosthetic Joint Infection Does Not Improve by a Combined Use of Glucose and Leukocyte Esterase Strip Reading as Diagnostic Parameters

The diagnosis of periprosthetic infections (PJI) can be challenging in clinical practice because the clinical presentations of aseptic loosening and low-grade infections are similar. Semiquantitative evaluation of leukocyte esterase (LE) in synovial fluid using a urine strip test has already established itself as a diagnostic method over the past decade. The analysis of LE in synovial fluid leads to a high number of false-positive test results. In the present study, the value of a combined semiquantitative determination of glucose and LE in synovial fluid to improve the diagnosis of PJI was investigated. Over a 4-year period, 145 synovial samples were collected from patients who developed joint effusion after arthroplasty. LE and glucose test strips were considered as an index test for the diagnosis of PJI. A ++ or +++ LE and a negative glucose test strip reading were considered as positive test results. Modified diagnostic criteria for PJI as recommended by the Musculoskeletal Infection Society (MSIS) served as the reference test, except that intraoperative findings were excluded. Forty-six out of 145 samples were classified as septic complication according to the reference test. In regard to PJI, our data showed that combined use of LE and glucose strip test reading displayed a 98.0% specificity (95% confidence interval (CI): 95.2% to 100%), a 50% sensitivity (95% CI: 35.6% to 64.4%), a 92% positive predictive value (95% CI: 81.4% to 100.0%), and an 80.3% negative predictive value (95% CI: 73.2% to 87.4%). In contrast, the exclusive analysis of LE on the urine strip to diagnose PJI demonstrated a 90.9% specificity (95% CI: 85.2% to 96.6%), a 67.4% sensitivity (95% CI: 53.8% to 80.9%), a 77.5% positive predictive value (95% CI: 64.6% to 90.4%), and an 85.7% negative predictive value (5% CI: 79.0% to 92.4%). A combination of LE and glucose test pad reading is considered superior as a potential “rule-in” method for the diagnosis of PJI compared with LE test pad analysis alone. However, combined LE and glucose synovial fluid testing also demonstrated lower test sensitivity and thus diagnostic accuracy compared with LE analysis alone. Therefore, combined glucose and LE test pad analysis does not represent a sufficient diagnostic standard to exclude PJI with certainty.
Human Omental Mesothelial Cells Impart an Immunomodulatory Landscape Impeding B- and T-Cell Activation

Mesothelial cells form the mesothelium, a simple epithelium lining the walls of serous cavities and the surface of visceral organs. Although mesothelial cells are phenotypically well characterized, their immunoregulatory properties remain largely unknown, with only two studies reporting their capacity to inhibit T cells through TGF-β and their consumption of L-arginine by arginase-1. Whether human mesothelial cells can suppress other immune cells and possess additional leukosuppressive mechanisms, remain to be addressed to better delineate their therapeutic potential for cell therapy. Herein, we generated secretomes from omental mesothelial cells (OMC) and assess their capacity to inhibit lymphocytes proliferation, suppress activated T and B cells, as well as to modify macrophage activation markers. The secretome from mesenchymal stromal cells (MSC) served as a control of immuno-suppression. Although OMC and MSC were phenotypically divergent, their cytokine secretion patterns as well as expression of inflammatory and immunomodulary genes were similar. As such, OMC- and MSC-derived secretomes (OMC-S and MSC-S) both polarized RAW 264.7 macrophages towards a M2-like anti-inflammatory phenotype and suppressed mouse and human lymphocytes proliferation. OMC-S displayed a strong ability to suppress mouse- and human-activated CD19+/CD25+ B cells as compared to MSC-S. The lymphosuppressive activity of the OMC-S could be significantly counteracted either by SB-431542, an inhibitor of TGFβ and activin signaling pathways, or with a monoclonal antibody against the TGFβ1, β2, and β3 isoforms. A strong blockade of the OMC-S-mediated lymphosuppressive activity was achieved using L-NMMA, a specific inhibitor of nitric oxide synthase (NOS). Taken together, our results suggest that OMC are potent immunomodulators.
Building With Benchmarks: The Role of the District in Philadelphia's Benchmark Assessment System

In recent years, interim assessments have become an increasingly popular tool in districts seeking to improve student learning and achievement. Philadelphia has been at the forefront of this change, implementing a set of Benchmark assessments aligned with its Core Curriculum district-wide in 2004. In this article, we examine the overall context for Benchmarks in Philadelphia, the expectations district leaders had for the use of those Benchmarks, the supports put in place to assist those in schools in meeting those expectations, and the challenges encountered in that implementation.
“Jesus got crucified, why should we expect any different?”; UK Christian clergies’ experiences of coping with role demands and seeking support*

ABSTRACT Clergy have an emotionally taxing role and are suggested to experience high rates of distress. Prior research suggests clergy utilise religious coping skills and may underutilise support. This study aimed to explore clergy experiences of role-demands, coping, and support, to supplement previous findings, and guide intervention. Nine clergy members participated in semi-structured interviews; data was analysed using inductive-deductive Thematic Analysis. Three major themes emerged from the data; ‘the sacrifice you make', ‘help along the way', and ‘change that's needed'. Clergy-members' most prevalent and salient reported coping strategy revolved around a stable relationship with God. Clergy discussed barriers to support within, and outside of, the church. Clergies' experiences of challenging demands and distress support previous findings. Clergy preference for religious coping suggest future research, or intervention, should account for spirituality. Finally, clergy-members’ varied experiences of support suggest practical/cultural changes within the church could reduce barriers.
Microbubble generation and large-scale assembly of colloidal particles by graphene oxide microstructures

The study of generation, growth and decay of microbubbles is interesting owing to its potential applications in imaging, trapping of colloidal particles and mass fluid flow. While there have been several reports on the generation of microbubbles using plasmonic nanostructure based substrates, they often are expensive and cumbersome to fabricate. In this study, we demonstrate a simple scheme for the generation of microbubbles using graphene oxide (GO) microstructures. Due to the excellent photothermal properties of this graphene-based 2D material, it is possible to generate and sustain microbubbles by laser illumination at low intensities of the order of few of μW μm−2. The size of the microbubbles can be tuned by changing the incident laser power. Furthermore, the generated microbubble acts as a concave wide-angle lens with variable focal length. We further utilised the fluid flow around the microbubble to generate large-scale assembly of silica beads and quantum dots using thermophoretic forces. This optically-assisted thermophoretic aggregation is rapid and reversible. Owing to the simple and cost-effective synthesis method of GO, this scheme is an excellent alternative to plasmonic heating based-methods for the generation of microbubbles .
Servant Leadership and Life Satisfaction at Public School in Indonesia: Career Satisfaction as Mediator

The research aimed to test servant leadership role in improving life satisfaction through career satisfaction. The method used was quantitative with structural equation modeling. The results showed that servant leadership has a positive and significant effect on career and life satisfaction, career satisfaction has a positive and significant influence on life satisfaction, and career satisfaction was a complementary mediator between servant leadership and teacher life satisfaction.
ED-B-Containing Isoform of Fibronectin in Tumor Microenvironment of Thymomas: A Target for a Theragnostic Approach

Simple Summary The extra-domain B fibronectin (ED-B FN) is highly expressed in thymic epithelial tumors (TETs), as demonstrated by in vivo targeting using 131I-labeled L19 small immunoprotein (131I-L19-SIP) and immunohistochemistry with a predominant expression by stromal cells of a thymoma microenvironment rather than epithelial cells. Such high expression derived from the induction of stromal cells shifts FN production to the ED-B subtype. Our results suggest that Radretumab radioimmunotherapy (R-RIT) inefficacy is not related to low TET ED-B expression but to multifactorial aspects including patients’ inherent characteristics, the pattern expression of the target, the biological characteristics of the tumor, and the format of the target agent, which contribute to the resistance of tumor cells to treatment. Abstract Aim: to exploit tissue-specific interactions among thymic epithelial tumor (TETs) cells and extra-domain B fibronectin (ED-B FN). Material and methods: The stromal pattern of ED-B FN expression was investigated through tumor specimen collection and molecular profiling in 11 patients with recurrent TETs enrolled in prospective theragnostic phase I/II trials with Radretumab, an ED-B FN specific recombinant human antibody. Radretumab radioimmunotherapy (R-RIT) was offered to patients who exhibited the target expression. Experiments included immunochemical analysis (ICH), cell cultures, immunophenotypic analysis, Western blot, slot-blot assay, and quantitative RT-PCR of two primary thymoma cultures we obtained from patients’ samples and in the Ty82 cell line. Results: The in vivo scintigraphic demonstration of ED-B FN expression resulted in R-RIT eligibility in 8/11 patients, of which seven were treated. The best observed response was disease stabilization (n = 5/7) with a duration of 4.3 months (range 3–5 months). IHC data confirmed high ED-B FN expression in the peripherical microenvironment rather than in the center of the tumor, which was more abundant in B3 thymomas. Further, there was a predominant expression of ED-B FN by the stromal cells of the thymoma microenvironment rather than the epithelial cells. Conclusions: Our data support the hypothesis that thymomas induce stromal cells to shift FN production to the ED-B subtype, likely representing a favorable hallmark for tumor progression and metastasis. Collectively, results derived from clinical experience and molecular insights of the in vitro experiments suggested that R-RIT inefficacy is unlikely related to low target expression in TET, being the mechanism of R-RIT resistance eventually related to patients’ susceptibility (i.e., inherent characteristics), the pattern expression of the target (i.e., at periphery), the biological characteristics of the tumor (i.e., aggressive and resistant phenotypes), and/or to format of the target agent (i.e., 131I-L19-SIP).
ALMA MATER: DESIGN AND EXPERIENCE IN THE WOMEN'S COLLEGES FROM THEIR NINETEENTH-CENTURY BEGINNINGS TO THE 1930s

philosophical statement on campus planning. Turner has re-established the importance of the visual, of the physical, and of the architectural in planning. Ultimately campus planning is the ordering of our physical environment and, hopefully, the creation of a beautiful and functional environment. All of the flow charts, traffic counts, opinion surveys, budgets, programs, committees, and meetings may help to clarify or only confuse, but they do not create a great campus. Campus planning is a visual act. The author’s term "architectural planning" very rightly links architecture and planning together. These are now separate professional fields and the training received for one does not necessarily encompass a working knowledge of the other. It is our loss. This history of the American campus clearly demonstrates the necessity of the generalist’s view, including planning, architecture, and landscape architecture. Turner’s description of the pastoral and open American college plan emphasizes the important spaces between buildings. Jos6 Luis Sert applied this interdisciplinary approach to our cities through his establishment of an urban design program at the Harvard Graduate School of Design in the 1950s. This same approach is needed, particularly today, for campus planning. Harold L. Goyette is a former director of planning for Harvard University and founding director and past president of the Society for College and University Planning. He is a principal of Cole and Goyette, Architects and Planners, Inc., 540 Franklin Street, Cambridge, Massachusetts 02139. ALMA MATER: DESIGN AND EXPERIENCE IN THE WOMEN’S COLLEGES FROM THEIR NINETEENTH-CENTURY BEGINNINGS TO THE 1930s, by Helen Lefkowitz Horowitz. New York: Alfred A. Knopf, 1984. xii +420 pages, illustrations, photographs, plans, notes, index. $25.00, clothbound. ISBN 0-394-53439-5
Mechanisms Underlying Antipsychotic-Induced NAFLD and Iron Dysregulation: A Multi-Omic Approach

Atypical antipsychotic (AA) medications are widely prescribed for the treatment of psychiatric disorders, including schizophrenia, bipolar disorder and treatment-resistant depression. AA are associated with myriad metabolic and endocrine side effects, including systemic inflammation, weight gain, dyslipidemia and insulin resistance, all of which are associated with increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is highly prevalent in patients with mental illness, and AA have been shown to increase incidence of NAFLD pre-clinically and clinically. However, the underlying mechanisms have not been described. We mined multi-omic datasets from preclinical murine models of sub-chronic risperidone or olanzapine treatment, in vitro exposure of human cells to risperidone and psychiatric patients following onset of aripiprazole therapy focused on pathways associated with the pathophysiology of NAFLD, including iron accumulation, systemic inflammation and dyslipidemia. We identified numerous differentially expressed traits affecting these pathways conserved across study systems and AA medications. We used these findings to propose mechanisms for AA-associated development of NAFLD and dysregulated iron homeostasis.
Performance Optimization of Atomic Layer Deposited HfOx Memristor by Annealing With Back-End-of-Line Compatibility

Hafnium oxide (HfOx) memristor has attracted enormous attention due to its high performance and back-end-of-line (BEOL) compatibility, thus providing a novel approach to implementing artificial intelligence neural networks. In this work, great performance optimization of HfOx memristor has been achieved by using atomic layer deposition (ALD) method and post-metal annealing (PMA) process, in which both procedures are with low-temperature budget (< 300 °C) and are compatible with CMOS BEOL process. The device exhibits forming-free, high yield, good linearity, fast speed and non-volatile characteristics. Besides, the device conductance can be well modulated by using the most desired pulse protocol, namely the identical pulse with same pulse amplitude and width. More than 3bit stable conductance states have been obtained, indicating its great potential in practical memristor neuromorphic computing system.
Effect of selenium on semen quality and fertility of rams

Objective: To evaluate the effect of different selenium (Se) doses on semen quality and fertility of rams. Design/Methodology/Approach: Se was administered subcutaneously each month to nine two-month-old rams (from April 2018 to February 2020). The treatments were: T1 = without Se, T2 = 0.1 mg Se kg-1, and T3 = 0.3 mg Se kg-1. Semen evaluations were carried out using an electroejaculator; a total of 180 ejaculations were analyzed. The rams with better semen quality (one per treatment) were subjected to a mating. The following variables were evaluated: volume (Vol), masal motility (MM), progressive motility (MP), sperm concentration per mL and ejaculation, acrosome integrity percentage, living spermatozoa, normal spermatozoa, and fertility percentage. The normal distribution variables were evaluated using an analysis of variance (ANOVA) and Tukey’s comparison test (Tukey, 0.05); the percentages were raised to the inverse sine in order to perform the appropriate ANOVA. Fertility was analyzed using a χ2 test. Results: There was no difference in semen quality and fertility percentage (p > 0.05). The ejaculation volume showed differences between treatments (p ≤ 0.05). Study Limitations/Implications: A study including a higher number of rams and a previous fieldwork practice should be carried out, in order to evaluate semen parameters. These evaluations would help to accurately estimate semen quality and fertility, as well as to corroborate the results. Findings/Conclusions: Se did not improve semen quality and fertility of rams
The Influence of Students’ Self-Determination and Personal Achievement Goals in Learning and Engagement: A Mediation Model for Traditional and Nontraditional Students

Self-determination theory (SDT) and achievement goal theory (AGT) assume that students’ level of self-determination and the goals they pursue in class are important factors in engagement and learning. The aims of this study were to: (1) investigate the links between the students’ types of motivation and personal achievement goals; (2) explore how these two sets of variables relate to learning, engagement, and exploring mediation effects; and (3) understand the specificities of nontraditional students vs. traditional students, regarding the way these variables relate to each other. The study used a sample of 361 Portuguese adult students, 138 traditional (younger than 25 years old), and 223 nontraditional (active adults returning to education, 25 or older). The instruments used were: Self-regulation Questionnaire—Learning, Personal Achievement Goal Orientations Scale, Adult Learning Strategies Evaluation Scale and Behavioral Engagement Questionnaire. Path analysis for the total sample revealed that mastery goals mediated the relationship between autonomous motivation and all educational outcomes, and performance-avoidance goals mediated the relationship between introjected regulation, external regulation, and behavioral and emotional engagement. Multiple-group path analysis revealed a much stronger pattern of relationships for nontraditional students, especially between the SDT and AGT variables. The theoretical and practical implications of the study are discussed.
Assessment of the Predictive Value of Spectrophotometric Skin Color Parameters and Environmental and Behavioral Factors in Estimating the Risk of Skin Cancer: A Case–Control Study

Keratinocyte carcinomas are the most common cancers with different etiological risk factors. The aim of this study was to assess the predictive value of spectrophotometric parameters of skin color in correlation with environmental/behavioral factors to estimate the risk of skin cancer. The case–control study involved 389 patients. The analysis was performed on the training group to build a predictive model and on the testing group to check the quality of the designed model. Area under the curve based on the spectrophotometric skin parameters varied from 0.536 to 0.674. A statistically significant improvement of the area under curve was achieved by adding the number of sunburns for some models. The best single spectrophotometric measurement for estimating skin cancer is the skin melanin index measured on the arm or buttock. Spectrophotometric skin parameters are not very strong but are essential elements of models for estimating the risk of skin cancer. The most important environmental/behavioral factor seems to be the number of sunburns, but not the total exposure to ultraviolet radiation or usage of photoprotectors. Some other pigmentation predictors should be taken into account when creating new models, especially those that can be easily measured in objective and repeatable way. Spectrophotometric measurements can be employed as quick screening skin examination method.
Devising optimal integration test orders using cost–benefit analysis

Integration testing is an integral part of software testing. Prior studies have focused on reducing test cost in integration test order generation. However, there are no studies concerning the testing priorities of critical classes when generating integration test orders. Such priorities greatly affect testing efficiency. In this study, we propose an effective strategy that considers both test cost and efficiency when generating test orders. According to a series of dynamic execution scenarios, the software is mapped into a multi-layer dynamic execution network (MDEN) model. By analyzing the dynamic structural complexity, an evaluation scheme is proposed to quantify the class testing priority with the defined class risk index. Cost—benefit analysis is used to perform cycle-breaking operations, satisfying two principles: assigning higher priorities to higher-risk classes and minimizing the total complexity of test stubs. We also present a strategy to evaluate the effectiveness of integration test order algorithms by calculating the reduction of software risk during their testing process. Experiment results show that our approach performs better across software of different scales, in comparison with the existing algorithms that aim only to minimize test cost. Finally, we implement a tool, ITOsolution, to help practitioners automatically generate test orders.
Examining the safety impacts of narrow lane widths on urban/suburban arterials: Estimation of a panel data random parameters negative binomial model

ABSTRACT Design practices in the United States generally allow substantial flexibility in the design of cross-sectional elements of urban and suburban arterial roadways. The operational and safety performance of such facilities is influenced by a variety of design controls, which influence the selection of important cross-sectional components, such as the number of lanes, lane widths, and the presence of shoulders, medians, or on-street parking. This study assesses the effects of lane width on the safety performance of urban and suburban arterial segments in the State of Nebraska. Ten years of traffic crash, volume, and roadway geometry data are analyzed to discern differences in the frequency of sideswipe-same direction and rear-end collisions across four functional classes of urban arterials. Crashes generally decreased as lane width increased, with 10-ft. lanes experiencing 18.1% more rear-end crashes and 27% more same-direction sideswipe collisions. In general, 12-ft. lanes showed fewer crashes than 11-ft. lanes. However, there was significant variability across the sample as 11-ft. lanes sometimes demonstrated fewer crashes, as well. These differences may be reflective of geometric characteristics that were not available in the dataset or of general differences in driver behavior across segments with varying cross-sectional characteristics.