Miracle-dz/UniFAR-FTUs huggingface dataset:
Identifying the Dynamics of Intangible Resources for Industry 4.0 Adoption Process

Industry 4.0 is a socioeconomic phenomenon that affects all industries, transforming not only products, processes, and services, but also business models, organizational structures, and strategies, placing human beings at the center of this digital transformation. Researchers have already demonstrated the importance of intangible resources in the Industry 4.0 adoption process. Nevertheless, there is still a gap in empirical research on how these factors evolve during the process. Therefore, the main objective of this study is to identify how these factors influence each other across different Industry 4.0 maturity levels. To achieve this goal, a qualitative approach was used with multiple case studies comparing responses from companies at higher Industry 4.0 maturity levels and contrasting them with the responses from companies at lower levels, distilling aggregate dimensions through an inductive coding procedure. Experts evaluated the results to find relations between the aggregate dimensions, their evolution and influence on each other. As a result, a conceptual framework was developed that demonstrates the dynamics of intangible factors that could be used by any company to nurture its own Intellectual Capital as a groundwork for the adoption of Industry 4.0. Among these dynamics, the central role of engaged leaders was highlighted in developing structural capital factors. Future studies should conduct interviews with more companies from other industrial sectors as well as on the implementation and management of Intellectual Capital in manufacturing companies to assess the applicability of the proposed conceptual framework.
Empirical investigation of the impact of overload on the discontinuous usage intentions of short video users: a stressor-strain-outcome perspective

PurposeThis study focuses on perceived overload from environmental stimuli and individual psychology and behavioral interactions. It constructs a theoretical model with overload as the key stressor based on the stressor-strain-outcome (SSO) model. The authors argue that system feature overload (SFO), information overload, and social overload lead to two psychological strains: fear of missing out (FoMO) and fatigue among users of short video platforms, affecting their discontinuous usage intentions.Design/methodology/approachTo test the hypotheses, the authors conducted a questionnaire survey on 412 users' short video platform usage and empirically tested the constructed model using the research tool SmartPLS 3.3. 2.FindingsThe results of data analysis showed that most of the hypotheses were supported. Specifically, system feature overload, information overload and social overload all positively affected FoMO. However, SFO and information overload significantly affected fatigue. There was no significant relationship between social overload and fatigue. In addition, both FoMO and fatigue negatively influenced users' discontinuous usage intentions.Originality/valueThe current research on user behavior in information systems tends to focus on the influence in the positive direction and less on the negative direction. The research on discontinuous usage intention (DUI) is a very new research topic. This research studies the influencing factors of users' discontinuous behavior from the perspective of perceptual overload. It provides a unique view for future short video platform user behavior research, with significant theoretical contributions and essential practice for short video platform operators to improve services.
Electrospun PCL/fibrin scaffold as a bone implant improved the differentiation of human adipose-derived mesenchymal stem cells into osteo-like cells

Abstract Bone remodeling is not able to repair the major injuries caused by trauma, cancer, etc. Bone tissue engineering is aimed to provide implants for bone repair or replacement. To approach such a purpose, polymeric scaffolds along with stem cells are used to fabricate a supportive matrix mimicking in vivo microenvironment. Here, we developed an in vivo-like matrix based on polycaprolactone (PCL) and fibrin to enhance the differentiation of human adipose-derived mesenchymal stem cells into osteo-like cells (AD-MSCs). PCL scaffold was fabricated by electrospinning and coated with fibrin. AD-MSCs were cultured and differentiate on PCL and PCL/fibrin. The viability of cultured cells in comparison with tissue culture plate (TCPS) was evaluated by MTT assay on days 1, 2, and 3 of differentiation. The differentiation was compared to TCPS on days 7, 14, and 21 of differentiation. To evaluate the differentiation efficiency, calcium content, alkaline phosphatase (ALP), and expression of RUNX-2, Collagene-I, Osteocalcin, and Osteonectin were assessed in differentiated cells. A slight increase in cell viability was observed in the TCPS group on day 3 of differentiation. Higher calcium content and ALP activity were observed in PCL and PCL/fibrin groups, respectively. The expression of osteogenic genes was higher in the PCL/fibrin group on days 7, 14, and 21 of differentiation. It seems PCL acts synergistically with fibrin to make an in vivo-like microenvironment and enhanced the differentiation of AD-MSCs into osteo-like cells. Graphical Abstract
Energy-momentum tensor on the lattice: Nonperturbative renormalization in Yang-Mills theory

We construct an energy-momentum tensor on the lattice which satisfies the appropriate Ward Identities (WIs) and has the right trace anomaly in the continuum limit. It is defined by imposing suitable WIs associated to the Poincare` invariance of the continuum theory. These relations come forth when the length of the box in the temporal direction is finite, and they take a particularly simple form if the coordinate and the periodicity axes are not aligned. We implement the method for the SU(3) Yang--Mills theory discretized with the standard Wilson action in presence of shifted boundary conditions in the (short) temporal direction. By carrying out extensive numerical simulations, the renormalization constants of the traceless components of the tensor are determined with a precision of roughly half a percent for values of the bare coupling constant in the range 0<= g^2_0<=1.
Issues on Barry Setterfield's Claims of a Recently Decaying Speed of Light, 2nd Edition1

A cartridge including a housing which holds a tape medium or disk medium and which is composed of upper and lower casings. The two casings are joined with screws in bosses formed at their four corners. The cartridge is characterized in that the bosses in at least one of the upper and lower casings have ends with partially different heights each so that, when the upper and lower casings are joined, their bosses come in contact with one another before the sidewalls of the in casings are mated.
Random Walk of Socially Responsible Investment in Emerging Market

Emerging markets offer some of the world’s most impactful investment possibilities for investors concerned with addressing global climate and socioeconomic issues. Sophisticated investors conjectured that socially responsible investment (SRI) or environmental social and governance (ESG) might give greater returns than investing in conventional stocks in an emerging market. At the same time, the investors favour conserving the environment while generating long-term economic growth. Being able to earn greater returns is an indication of an inefficient market. This paper investigates the random walk (weak-form of the efficient market) of SRI/ESG indices in the emerging market (based on IMF emerging market criteria). We use the daily data as a sample. Random walk is tested using an Augmented Dickey–Fuller (ADF) Unit Root test, Variance ratio test and Hurst exponent test. The findings report that all the indices are not following a random walk. Lack of ESG disclosure, inadequate corporate governance regulation and behavioural bias might be reasons for market inefficiency. Its implications for investors to reap abnormal market returns by identifying the undervalued stock in the emerging economies. The regulator’s approval of operational guidelines and the licensing of exchanges and clearing houses help maintain the markets’ fairness. Then, the regulator should intensify corporate governance enhancement, implementation and enforcement continuously; enhance the market and institutional infrastructure, and focus policy on encouraging a more significant and more diverse investor base.
Equipped for Sexual Stings? Male-Specific Venom Peptides in Euscorpius italicus

In the animal kingdom, intraspecific variation occurs, for example, between populations, different life stages, and sexes. For venomous animals, this can involve differences in their venom composition. In cases where venom is utilized in the context of mating, the differences in composition might be driven by sexual selection. In this regard, the genus Euscorpius is a promising group for further research, as some of these scorpions exhibit a distinct sexual dimorphism and are known to perform a sexual sting during mating. However, the venom composition of this genus remains largely unexplored. Here, we demonstrate that Euscorpius italicus exhibits a male-specific venom composition, and we identify a large fraction of the substances involved. The sex specificity of venom peptides was first determined by analyzing the presence/absence patterns of ion signals in MALDI-TOF mass spectra of venom samples from both sexes and juveniles. Subsequently, a proteo-transcriptomic analysis provided sequence information on the relevant venom peptides and their corresponding precursors. As a result, we show that several potential toxin precursors are down-regulated in male venom glands, possibly to reduce toxic effects caused to females during the sexual sting. We have identified the precursor of one of the most prominent male-specific venom peptides, which may be an ideal candidate for activity tests in future studies. In addition to the description of male-specific features in the venom of E. italicus, this study also includes a general survey of venom precursors in this species.
TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein

The presence of proteinopathy, the accumulation of specific proteins as aggregates in neurons, is an emerging aspect of the pathology of schizophrenia and other major mental illnesses. Among the initial proteins implicated in forming such aggregates in these conditions is Trio and F-actin Binding Protein isoform 1 (TRIOBP-1), a ubiquitously expressed protein involved in the stabilization of the actin cytoskeleton. Here we investigate the insolubility of TRIOBP-1, as an indicator of aggregation, in brain samples from 25 schizophrenia patients, 25 major depressive disorder patients and 50 control individuals (anterior cingulate cortex, BA23). Strikingly, insoluble TRIOBP-1 is considerably more prevalent in both of these conditions than in controls, further implicating TRIOBP-1 aggregation in schizophrenia and indicating a role in major depressive disorder. These results were only seen using a high stringency insolubility assay (previously used to study DISC1 and other proteins), but not a lower stringency assay that would be expected to also detect functional, actin-bound TRIOBP-1. Previously, we have also determined that a region of 25 amino acids in the center of this protein is critical for its ability to form aggregates. Here we attempt to refine this further, through the expression of various truncated mutant TRIOBP-1 vectors in neuroblastoma cells and examining their aggregation. In this way, it was possible to narrow down the aggregation-critical region of TRIOBP-1 to just 8 amino acids (333–340 of the 652 amino acid-long TRIOBP-1). Surprisingly our results suggested that a second section of TRIOBP-1 is also capable of independently inducing aggregation: the optionally expressed 59 amino acids at the extreme N-terminus of the protein. As a result, the 597 amino acid long version of TRIOBP-1 (also referred to as “Tara” or “TAP68”) has reduced potential to form aggregates. The presence of insoluble TRIOBP-1 in brain samples from patients, combined with insight into the mechanism of aggregation of TRIOBP-1 and generation of an aggregation-resistant mutant TRIOBP-1 that lacks both these regions, will be of significant use in further investigating the mechanism and consequences of TRIOBP-1 aggregation in major mental illness.
Fire–climate interactions through the aerosol radiative effect in a global chemistry–climate–vegetation model

Abstract. Fire emissions influence radiation, climate, and ecosystems through aerosol radiative effects. These can drive rapid atmospheric and land surface adjustments which feed back to affect fire emissions. However, the magnitude of such feedback remains unclear on the global scale. Here, we quantify the impacts of fire aerosols on radiative forcing and the fast atmospheric response through direct, indirect, and albedo effects based on the two-way simulations using a well-established chemistry–climate–vegetation model. Globally, fire emissions cause a reduction of 0.565 ± 0.166 W m−2 in net radiation at the top of the atmosphere with dominant contributions by the aerosol indirect effect (AIE). Consequently, terrestrial surface air temperature decreases by 0.061 ± 0.165 ∘C with coolings of >0.25 ∘C over the eastern Amazon, the western US, and boreal Asia. Both the aerosol direct effect (ADE) and AIE contribute to such cooling, while the aerosol albedo effect (AAE) exerts an offset warming, especially at high latitudes. Land precipitation decreases by 0.180 ± 0.966 mm per month (1.78 % ± 9.56 %) mainly due to the inhibition in central Africa by AIE. Such a rainfall deficit further reduces regional leaf area index (LAI) and lightning ignitions, leading to changes in fire emissions. Globally, fire emissions reduce by 2 %–3 % because of the fire-induced fast responses in humidity, lightning, and LAI. The fire aerosol radiative effects may cause larger perturbations to climate systems with likely more fires under global warming.
Homeomorphisms without the pseudo-orbit tracing property

Recently, A. Morimoto [5] proved that every isometry of a compact Riemannian manifold of positive dimension has not the pseudo-orbit tracing property, and that if a homeomorphism of a compact metric space has the pseudo-orbit tracing property then Eφ— 0φ (see § 1 for definition). The purpose of this paper is to show that every distal homeomorphism of a compact connected metric space has not the pseudo-orbit tracing property.
Serum lead, mercury, manganese, and copper and DNA methylation age among adults in Detroit, Michigan

Abstract Although the effects of lead, mercury, manganese, and copper on individual disease processes are well understood, estimating the health effects of long-term exposure to these metals at the low concentrations often observed in the general population is difficult. In addition, the health effects of joint exposure to multiple metals are difficult to estimate. Biological aging refers to the integrative progression of multiple physiologic and molecular changes that make individuals more at risk of disease. Biomarkers of biological aging may be useful to estimate the population-level effects of metal exposure prior to the development of disease in the population. We used data from 290 participants in the Detroit Neighborhood Health Study to estimate the effect of serum lead, mercury, manganese, and copper on three DNA methylation-based biomarkers of biological aging (Horvath Age, PhenoAge, and GrimAge). We used mixed models and Bayesian kernel machine regression and controlled for participant sex, race, ethnicity, cigarette use, income, educational attainment, and block group poverty. We observed consistently positive estimates of the effects between lead and GrimAge acceleration and mercury and PhenoAge acceleration. In contrast, we observed consistently negative associations between manganese and PhenoAge acceleration and mercury and Horvath Age acceleration. We also observed curvilinear relationships between copper and both PhenoAge and GrimAge acceleration. Increasing total exposure to the observed mixture of metals was associated with increased PhenoAge and GrimAge acceleration and decreased Horvath Age acceleration. These findings indicate that an increase in serum lead or mercury from the 25th to 75th percentile is associated with a ∼0.25-year increase in two epigenetic markers of all-cause mortality in a population of adults in Detroit, Michigan. While few of the findings were statistically significant, their consistency and novelty warrant interest.
Temporal Characterization of Electron Beam Bunches with a Fast Streak Camera at the JLab FEL Facility

The design and construction of an optical transport that brings synchrotron radiation from electron bunches to a fast streak camera in a remote area has become a useful tool for online observation of bunch length and stability. This paper will report on the temporal measurements we have done, comparison with simulations, and the on-going work for another imaging optical transport system that will make possible the direct measurement of the longitudinal phase space by measuring the bunch length as a function of energy
Pollination ecology and breeding system of the tropical tree Guaiacum sanctum on two Caribbean islands with contrasting pollinator assemblages

Insular pollination systems are more extinction-prone and vulnerable to invasive species than mainland ones. They often have plants with reproductive mechanisms allowing for self-compatibility and low species-rich communities of pollinators. Here, we document different reproductive traits of the tropical tree Guaiacum sanctum on two insular populations with contrasting pollinator assemblages: Guánica in Puerto Rico with alien honeybees and Mona Island where honeybees do not occur. Using field observations and pollination experiments, we evaluated pollinator species richness, visitation rates, breeding system, and the fitness of selfed- vs. crossed-progenies. We found that flowers are pollinated by insects on both islands, but while the species richness of pollinators was higher on Mona, the visitation rates were considerably higher in Guánica where trees are almost exclusively visited by the introduced Apis mellifera. Flowers are not apomictic, and autogamy is negligible indicating that pollinators are required to set fruits. Outcrossing yielded nearly twice the number of fruits and seeds than selfing and these differences were consistent between populations, which might reflect early acting inbreeding depression, partial self-incompatibility, or differences in resource allocation between selfed and outcrossed fruits. Our combined results suggest that the substantial reduction in pollinator visitors in areas dominated by A. mellifera may add an additional level of vulnerability to these threatened populations. Although reproductive fitness is higher in Guánica, mostly due to the pollination services provided by A. mellifera, this population may be more susceptible to environmental changes and large-scale disturbances affecting pollinator abundance given the reduced diversity of flower visitors.
Protective Effects of a Polyphenol-Rich Blueberry Extract on Adult Human Neural Progenitor Cells

The aging process impacts neural stem cells and causes a significant decline in neurogenesis that contributes to neuronal dysfunction leading to cognitive decline. Blueberries are rich in polyphenols and have been shown to improve cognition and memory in older humans. While our previous studies have shown that blueberry supplementations can increase neurogenesis in aged rodents, it is not clear whether this finding can be extrapolated to humans. We thus investigated the effects of blueberry treatments on adult hippocampal human neural progenitor cells (AHNPs) that are involved in neurogenesis and potentially in memory and other brain functions. Cultured AHNPs were treated with blueberry extract at different concentrations. Their viability, proliferation, and differentiation were evaluated with and without the presence of a cellular oxidative stressor, dopamine, and potential cellular mechanisms were also investigated. Our data showed that blueberry extract can significantly increase the viability and proliferation rates of control hippocampal AHNPs and can also reverse decreases in viability and proliferation induced by the cellular stressor dopamine. These effects may be associated with blueberry’s anti-inflammatory, antioxidant, and calcium-buffering properties. Polyphenol-rich berry extracts thus confer a neuroprotective effect on human hippocampal progenitor cells in vitro.
Integrative taxonomy of the stick insect genus Austrocarausius Brock, 2000 (Phasmatodea: Lonchodidae) reveals cryptic species in remnant Queensland rainforests

Abstract. Austrocarausius Brock, 2000 is a stick insect (Phasmatodea: Lonchodidae) genus containing two species restricted to the tropical rainforests of northern Queensland. Recent specimen collections between the two species’ type localities, Lizard Island and Rockhampton, have suggested that Austrocarausius might represent more than the two nominal species. Here, we apply morphological and molecular analyses to revise the taxonomy of this genus. Using both field-collected and historic museum samples, we developed morphological species hypotheses and descriptions. Genetic sequencing of mitochondrial COI and 16S were undertaken for species delimitation and phylogenetic analysis, including an estimate of the evolutionary timescale of the genus. Based on these results, we propose nine new Austrocarausius species, increasing the number of species in the genus to eleven: A. nigropunctatus (Kirby, 1896), A. mercurius (Stål, 1877), A. coronatus sp. nov., A. decorus sp. nov., A. eirmosus sp. nov., A. gasterbulla sp. nov., A. tuberosus sp. nov., A. macropunctatus sp. nov., A. truncatus sp. nov. A. waiben sp. nov. and A. walkeri sp. nov. Our results suggest Austrocarausius species diversified over the last c. 25–70Ma, resulting in the now endemic distributions in the tropical rainforests of the central and northern Queensland coasts. This is the first integrative systematic study of an Australian phasmid genus, combining morphological, molecular and biogeographical methods. Additional species of Austrocarausius likely remain undescribed as can be inferred from methodical sampling of rainforest patches along the Queensland coast.
Mechanical, Structural, and Biological Characteristics of Polylactide/Wollastonite 3D Printed Scaffolds

The present work aimed to study the synergistic response of bioresorbable polylactide/bioactive wollastonite scaffolds towards mechanical stability, mesenchymal stromal cell colonization, and antibacterial activity in the physiological environment. Wollastonite was synthesized at 800 °C within 2 h by sol-gel combustion method. The surface area was found to be 1.51 m2/g, and Transmission Electron Microscopy (TEM) micrographs indicated the presence of porous structures. Fused deposition modeling was used to prepare 3D-printed polylactide/wollastonite and polylactide/hydroxyapatite scaffolds. Scanning Electron Microscopy (SEM) micrographs confirmed the interconnected porous structure and complex geometry of the scaffolds. The addition of wollastonite decreased the contact angle of the scaffolds. The mechanical testing of scaffolds examined by computational simulation, as well as machine testing, revealed their non-load-bearing capacity. The chemical constituent of the scaffolds was found to influence the attachment response of different cells on their surface. The incorporation of wollastonite effectively reduced live bacterial attachment, whereas the colonization of mesenchymal cells was improved. This observation confirms polylactide/wollastonite scaffold possesses both bactericidal as well as cytocompatible properties. Thus, the risk of peri-implant bacterial film formation can be prevented, and the biological fixation of the scaffold at the defect site can be enhanced by utilizing these composites.