Miracle-dz/UniFAR-FTUs huggingface dataset:
A meta-analysis of the effects of episodic future thinking on delay discounting

Delay discounting (DD) refers to the phenomenon in which the subjective value of future rewards is reduced over time. There are individual differences in the DD rate, and increased discounting has been observed in those with various psychiatric disorders. Episodic future thinking (EFT) is the act of vividly imagining events that may happen in the future. Studies have shown that EFT could reduce DD, although inconsistent results have been reported. The aim of this meta-analysis was to clarify the efficacy with which EFT reduces DD and to identify potential moderators. Forty-seven studies (including 63 contrasts) were included in the final analysis. EFT was found to significantly reduce DD (Hedges’ g = 0.52). Moderator analysis showed that positive EFT (g = 0.64) was more effective in reducing DD than EFT with the valence not specifically mentioned (g = 0.28) and EFT with neutral or negative valence (g = –0.03). In addition, several factors related to the control task and DD task were related to the efficacy of EFT to reduce DD. These findings have implications for using EFT to reduce DD in the future.
Adherence to the South African food based dietary guidelines may reduce breast cancer risk in black South African women: the South African Breast Cancer (SABC) study

Abstract Objective: To determine the level of adherence and to assess the association between higher adherence to the South African food based dietary guidelines (SAFBDG) and breast cancer risk. Design: Population-based, case–control study (the South African Breast Cancer study) matched on age and demographic settings. Validated questionnaires were used to collect dietary and epidemiological data. To assess adherence to the SAFBDG, a nine-point adherence score (out of eleven guidelines) was developed, using suggested adherence cut-points for scoring each recommendation (0 and 1). When the association between higher adherence to the SAFBDG and breast cancer risk was assessed, data-driven tertiles among controls were used as cut-points for scoring each recommendation (0, 0·5 and 1). OR and 95 % CI were estimated using multivariate logistic regression models. Setting: Soweto, South Africa. Participants: Black urban women, 396 breast cancer cases and 396 controls. Results: After adjusting for potential confounders, higher adherence (>5·0) to the SAFBDG v. lower adherence (<3·5) was statistically significantly inversely associated with breast cancer risk overall (OR = 0·56, 95 % CI 0·38, 0·85), among postmenopausal women (OR = 0·64, 95 % CI 0·40, 0·97) as well as for oestrogen-positive breast cancers (OR = 0·51, 95 % CI 0·32, 0·89). Only 32·3 % of cases and 39·1 % of controls adhered to at least half (a score >4·5) of the SAFBDG. Conclusions: Higher adherence to the SAFBDG may reduce breast cancer risk in this population. The concerning low levels of adherence to the SAFBDG emphasise the need for education campaigns and to create healthy food environments in South Africa to increase adherence to the SAFBDG.
StemBells: A novel stem cell delivery platform using microbubbles and ultrasound

markdownabstract__Abstract__ Bubbles are omnipresent. It is the popping of bubbles present in the water that produces the characteristic sound of meandering brooks, boiling water [1] and breaking waves at the beach. The popping of bubbles can generate great forces, an effect which is employed in ultrasound baths to remove dirt and biofilms from all kind of objects, such as jewelry. In the ocean, pistol shrimps make use of the violent collapse of bubbles, produced by the rapid closure of their special snapper claw, to daze their preys. Furthermore, without the presence of tiny (carbon dioxide) bubbles, soft drinks would not have the sparkling taste and beers not a foamy head. Bubbles are also good adsorbers of dirt, which is used in industry to clean greasy machinery and piping.
Fabrication of wavelength-tunable InGaAsP/InP grating-assisted codirectional coupler filter with very narrow bandwidth

A wavelength-tunable grating-assisted codirectional coupler optical filter with a full coupling length of 4.5 mm has been designed and fabricated by reactive ion etching and metal organic chemical vapour deposition techniques. The centre wavelength and bandwidth for TE-polarisation were 1530.6 and 1.5 nm, respectively, and those for TM-polarisation were 1494.0 and 1.3 nm. respectively, which is one of the narrowest reported. When a current of 100 mA was injected into a lower index waveguide, the central wavelength shifted by 7.8 nm towards the longer wavelength side.
Neonatal Outcomes of Premature Infants Born to Women with the Novel Coronavirus (SARS-CoV-2) Infection: A Case Control Study

Abstract Objective Novel coronavirus disease 2019 (COVID-19) is a disease associated with atypical pneumonia caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The first cases of COVID-19 were reported in Wuhan at the end of 2019. Transmission usually occurs via infected droplets and close personal contact; the possibility of vertical transmission is still under debate. This retrospective study aimed to analyze clinical characteristics of premature infants born to mothers with symptomatic COVID-19 disease. Study Design This case control study compared the clinical and laboratory data of 20 premature infants born to mothers infected with SARS-CoV-2 with sex and gestational age–matched historical controls. Results The median gestational age and birth weight in both groups were similar. Respiratory distress developed in 11 (55.5%) infants in study group and 19 (47.5%) infants in control group. Mechanical ventilation and endotracheal surfactant administration rates were similar. Median duration of hospitalization was 8.5 (2–76) days in study group and 12 days in historical controls. Real-time reverse-transcription polymerase chain reaction tests (RT-PCR) of nasopharyngeal swab samples for SARS-CoV-2 were found to be negative twice, in the first 24 hours and later at 24 to 48 hours of life. No neutropenia or thrombocytopenia was detected in the study group. Patent ductus arteriosus, bronchopulmonary dysplasia, and necrotizing enterocolitis rates were similar between groups. No mortality was observed in both groups. Conclusion To the best of our knowledge, this is one of the few studies evaluating the clinical outcomes of premature infants born to SARS-CoV-2 infected mothers. There was no evidence of vertical transmission of SARS-CoV-2 from symptomatic SARS-CoV-2-infected women to the neonate in our cohort. The neonatal outcomes also seem to be favorable with no mortality in preterm infants. Key Points SARS-CoV-2 pandemic is a challenge for pregnant women. Neonatal outcomes of premature infants born to mothers infected with SARS-CoV-2 not well defined. SARS-CoV-2 infection seems to have no adverse effect on mortality and morbidity in premature infants.
An Experimental Study on Lift Force Generation Resulting from Spanwise Flow in Flapping Wings

Using a combination of force transducer measurement to quantify net lift force, high frame rate camera to quantify and subtract inertial contributions, and Digital Particle Image Velocimetry (DPIV) to calculate aerodynamic contributions in the spanwise plane, the contribution of spanwise flow to the generation of lift force in wings undergoing a pure flapping motion in hover is shown as a function of flapping angle throughout the flapping cycle. These experiments were repeated at various flapping frequencies and for various wing planform sizes for flat plate and span wise cambered wings. Despite the previous identification of the importance of span wise fluid structures in the generation of lift force in flapping wings throughout the existing body of literature, the direct contribution of spanwise flow to lift force generated has not previously been quantified. Therefore, in the same manner as commonly applied to investigate the chordwise lift distribution across an airfoil in flapping wings, spanwise flow due to bulk flow and rotational fluid dynamic mechanisms will be investigated to validate the existence of a direct component of the lift force originating from the flapping motion in the spanwise plane instead.
Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer

SARS-CoV-2, a novel Betacoronavirus, was first reported circulating in human populations in December 2019 and has since become a global pandemic. Recent history involving SARS-like coronavirus outbreaks (SARS-CoV and MERS-CoV) have demonstrated the significant role of intermediate and reservoir hosts in viral maintenance and transmission cycles. Evidence of SARS-CoV-2 natural infection and experimental infections of a wide variety of animal species has been demonstrated, and in silico and in vitro studies have indicated that deer are susceptible to SARS-CoV-2 infection. White-tailed deer (Odocoileus virginianus) are amongst the most abundant, densely populated, and geographically widespread wild ruminant species in the United States. Human interaction with white-tailed deer has resulted in the occurrence of disease in human populations in the past. Recently, white-tailed deer fawns were shown to be susceptible to SARS-CoV-2. In the present study, we investigated the susceptibility and transmission of SARS-CoV-2 in adult white-tailed deer. In addition, we examined the competition of two SARS-CoV-2 isolates, representatives of the ancestral lineage A (SARS-CoV-2/human/USA/WA1/2020) and the alpha variant of concern (VOC) B.1. 1.7 (SARS-CoV-2/human/USA/CA_CDC_5574/2020), through co-infection of white-tailed deer. Next-generation sequencing was used to determine the presence and transmission of each strain in the co-infected and contact sentinel animals. Our results demonstrate that adult white-tailed deer are highly susceptible to SARS-CoV-2 infection and can transmit the virus through direct contact as well as vertically from doe to fetus. Additionally, we determined that the alpha VOC B.1. 1.7 isolate of SARS-CoV-2 outcompetes the ancestral lineage A isolate in white-tailed deer, as demonstrated by the genome of the virus shed from nasal and oral cavities from principal infected and contact animals, and from virus present in tissues of principal infected deer, fetuses and contact animals.
Understanding over-squashing and bottlenecks on graphs via curvature

Most graph neural networks (GNNs) use the message passing paradigm, in which node features are propagated on the input graph. Recent works pointed to the distortion of information flowing from distant nodes as a factor limiting the efficiency of message passing for tasks relying on long-distance interactions. This phenomenon, referred to as 'over-squashing', has been heuristically attributed to graph bottlenecks where the number of $k$-hop neighbors grows rapidly with $k$. We provide a precise description of the over-squashing phenomenon in GNNs and analyze how it arises from bottlenecks in the graph. For this purpose, we introduce a new edge-based combinatorial curvature and prove that negatively curved edges are responsible for the over-squashing issue. We also propose and experimentally test a curvature-based graph rewiring method to alleviate the over-squashing.
Outcome of left atrial appendage closure using cerebral protection system for thrombosis: no patient left behind

Left atrial appendage (LAA) thrombosis increases the risk of stroke and its management has to be assessed. The aim of the present study is to evaluate short and long‐term safety and efficacy of a standardized approach of percutaneous LAA closure (LAAC) routinely using a cerebral protection device (CPD) in patients with LAA thrombosis or sludge (LAAT).
Body composition in sexual precocity

Purpose of review In this review, we have summarized the current data on the effect of sexual precocity and treatment with gonadotropin-releasing hormone analogues (GnRHa) on body composition. Recent findings Higher body weight and weight gain in infancy and childhood may increase the risk of early puberty in girls. The relation between BMI and pubertal onset in boys is controversial. Current studies draw attention to the fact that a similar relationship may exist in boys too. Obesity prevalence is high among girls with central precocious puberty (CPP) and treatment with GnRHa has a different effect on BMI according to baseline body composition. Although BMI values of normal weight girls tend to increase under treatment, they return to normal following treatment. The few studies that have followed up body composition longitudinally in girls show a gradual increase in adiposity, decrease in muscle mass and bone mineral density during GnRHa treatment, whereas bone mass was preserved after treatment. Adequate data are not available in boys to determine the effect of GnRHa therapy on body composition. Summary Body composition and fat distribution should be monitored longitudinally in patients with CPP treated with GnRHa to ascertain the long-term effects of therapy.
Driver Injury Severity Resulting from Single-Vehicle Crashes along Horizontal Curves on Rural Two-Lane Highways

Horizontal curves have been identified as a target area for improving safety on rural two-lane highways in Texas. This study involved the development of multinomial logit models to assess driver injury severity resulting from single-vehicle crashes on such roads. Likelihood ratio tests warranted the development of separate injury severity models for curves of small, medium, and large radius. Various driver, vehicle, roadway, and environmental characteristics were found to affect injury severity among the 10,029 crashes analyzed. Run-off-the-road crashes, particularly those resulting in collisions with roadside objects, were found to increase injury severity significantly. Females were more likely to sustain injury and older drivers to be critically injured, particularly on curves of smaller radius. Various driver actions and behaviors were also significant determinants of injury severity. Unbelted drivers were up to 10 times more likely to suffer fatal injuries, and drivers who were uninsured, fatigued, or under the influence of drugs or alcohol were more likely to be seriously injured. Several of these behavioral factors were more pronounced on sharper curves.
Performance analysis of dedicated short range communications technology and overview of the practicability for developing countries

Vehicular communication is a widely researched field and aims at developing technologies that may complement systems such as the advanced driver assistance systems. It is therefore important to analyse and infer on the performance of vehicular technologies for different driving and on-road criteria. This study considers the dedicated short range communications technology and more precisely the IEEE 802.11p standard for a performance and practicability analysis. There is also the proposal of a new classification scheme for typical driving conditions, which includes the main categories of Emergency and Safety scenarios while sub-classifications of Critical and Preventive Safety also exist. The scheme is used to build up scenarios as well as related equations relevant to developing countries for practical network simulation. The results obtained indicate that the relative speed of nodes is a determining factor in the overall performance and effectiveness of wireless vehicular communication systems. Moreover, delay values of low order were observed while an effective communication range of about 800 m was calculated for highway scenarios. The research thus indicates suitability of the system for an active use in collision avoidance even though independent factors such as climatic conditions and driver behaviour may affect its effectiveness in critical situations.
The causes of project failure

A study was conducted of 97 projects identified as failures by the projects' managers or parent organizations. Using the project implementation profile, a set of managerially controllable factors is identified as associated with project failure. The factors differed according to three contingency variables: the precise way in which failure was defined; the type of project, and the stage of the project in its life cycle. Implications for project management and for future research on failed projects are discussed. The results demonstrated empirical justification for a multidimensional construct of project failure, encompassing both internal efficiency and external effectiveness aspects. The fact that the critical factors associated with failure depended on the way in which failure is defined suggests that it is necessary to know considerably more about how project managers define failure (and success) and, indeed how the parent organization makes judgments on the matter. >
Fitting double-hit lymphoma into the aggressive lymphoma spectrum: a square peg in a round hole?

Abstract High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements or both, commonly called double-hit lymphoma (DHL), is an aggressive B-cell lymphoma that is molecularly distinct from diffuse large B-cell lymphoma (DLBCL) and is associated with poor outcomes. Recent advances in the molecular classification of DLBCL have identified distinct subsets, including genetic signatures which correlate with DHL and survival. DHL with concomitant TP53 mutation appears to be associated with a very poor prognosis. Standard chemo-immunotherapy is not an effective treatment for these patients and personalized, innovative strategies are needed. In this review, we summarize recent advances in the subclassification of DLBCL, with a focus on DHL. We also incorporate early, promising clinical trial data using CAR T and targeted therapies. Rationally designed clinical trials for DLBCL are needed to advance the care of patients with DHL and other adverse risk DLBCL subgroups.
Energy-Efficient Implementation of Generative Adversarial Networks on Passive RRAM Crossbar Arrays

Generative algorithms such as GANs are at the cusp of next revolution in the field of unsupervised learning and large-scale artificial data generation. However, the adversarial (competitive) co-training of the discriminative and generative networks in GAN makes them computationally intensive and hinders their deployment on the resource-constrained IoT edge devices. Moreover, the frequent data transfer between the discriminative and generative networks during training significantly degrades the efficacy of the von-Neumann GAN accelerators such as those based on GPU and FPGA. Therefore, there is an urgent need for development of ultra-compact and energy-efficient hardware accelerators for GANs. To this end, in this work, we propose to exploit the passive RRAM crossbar arrays for performing key operations of a fully-connected GAN: (a) true random noise generation for the generator network, (b) vector-by-matrix-multiplication with unprecedented energy-efficiency during the forward pass and backward propagation and (C) in-situ adversarial training using a hardware friendly Manhattan's rule. Our extensive analysis utilizing an experimentally calibrated phenomological model for passive RRAM crossbar array reveals an unforeseen trade-off between the accuracy and the energy dissipated while training the GAN network with different noise inputs to the generator. Furthermore, our results indicate that the spatial and temporal variations and true random noise, which are otherwise undesirable for memory application, boost the energy-efficiency of the GAN implementation on passive RRAM crossbar arrays without degrading its accuracy.
Effect of Rashba and Dresselhaus spin–orbit coupling on supercurrent rectification and magnetochiral anisotropy of ballistic Josephson junctions

Simultaneous breaking of inversion- and time-reversal symmetry in Josephson junction (JJ) leads to a possible violation of the I(φ) = −I(−φ) equality for the current–phase relation. This is known as anomalous Josephson effect and it produces a phase shift φ 0 in sinusoidal current–phase relations. In ballistic JJs with non-sinusoidal current phase relation the observed phenomenology is much richer, including the supercurrent diode effect and the magnetochiral anisotropy (MCA) of Josephson inductance. In this work, we present measurements of both effects on arrays of JJs defined on epitaxial Al/InAs heterostructures. We show that the orientation of the current with respect to the lattice affects the MCA, possibly as the result of a finite Dresselhaus component. In addition, we show that the two-fold symmetry of the Josephson inductance reflects in the activation energy for phase slips.
Implicit Equivariance in Convolutional Networks

Convolutional Neural Networks(CNN) are inherently equivariant under translations, however, they do not have an equivalent embedded mechanism to handle other transformations such as rotations and change in scale. Several approaches exist that make CNNs equivariant under other transformation groups by design. Among these, steerable CNNs have been especially effective. However, these approaches require redesigning standard networks with filters mapped from combinations of predefined basis involving complex analytical functions. We experimentally demonstrate that these restrictions in the choice of basis can lead to model weights that are sub-optimal for the primary deep learning task (e.g. classification). Moreover, such hard-baked explicit formulations make it difficult to design composite networks comprising heterogeneous feature groups. To circumvent such issues, we propose Implicitly Equivariant Networks (IEN) which induce equivariance in the different layers of a standard CNN model by optimizing a multi-objective loss function that combines the primary loss with an equivariance loss term. Through experiments with VGG and ResNet models on Rot-MNIST , Rot-TinyImageNet, Scale-MNIST and STL-10 datasets, we show that IEN, even with its simple formulation, performs better than steerable networks. Also, IEN facilitates construction of heterogeneous filter groups allowing reduction in number of channels in CNNs by a factor of over 30% while maintaining performance on par with baselines. The efficacy of IEN is further validated on the hard problem of visual object tracking. We show that IEN outperforms the state-of-the-art rotation equivariant tracking method while providing faster inference speed.
Muonium Lamb shift: theory update and experimental prospects

We review the theory of the Lamb shift for muonium, provide an updated numerical value and present the prospects of the Mu-MASS collaboration at PSI to improve upon their recent measurement. Due to its smaller nuclear mass, the contributions of the higher-order recoil corrections (160 kHz level) and nucleus self-energy (40 kHz level) are enhanced for muonium compared to hydrogen where those are below the level of the latest measurement performed by Hessels et al. and thus could not be tested yet. The ongoing upgrades to the Mu-MASS setup will open up the possibility to probe these contributions and improve the sensitivity of this measurement to searches for new physics in the muonic sector.
Helicobacter pylori infection and the progression of atherosclerosis: A systematic review and meta‑analysis

In recent years, many studies have tried to prove whether Helicobacter pylori (H. pylori) can promote the progression of atherosclerosis (AS), but the reported results are conflicting. Carotid intima‐media thickness (CIMT), flow‐mediated dilation (FMD), or pulse wave velocity (PWV) are the most commonly used indicators to evaluate the progress of AS. So, we collected and evaluated these three indicators to provide evidence‐based medicine for the clinic.