Miracle-dz/UniFAR-FTUs huggingface dataset:
Interferon beta 1a (Rebif®) in relapsing remitting multiple sclerosis

Multiple sclerosis (MS) is an autoimmune neurodegenerative disease that affects the central nervous system. It is the second cause of neurological disability in young adults. The exact cause of the disease remains unknown and there is no curative treatment. It is imperative to evaluate the efficacy of newest, biotechnological products modifying the disease. This study was designed to evaluate the use of interferon beta 1a (Rebif®) in patients with relapsing remitting MS treated at International Center for Neurological Restoration. Thirty‐one patients with relapsing remitting MS, between 10 and 65 years of age, four males and 27 females, were treated with Rebif® three times per week during 1 year. The safety of the treatment was evaluated based on the adverse events and the efficacy based on the disability scale score, the number of attacks and the number of lesions at magnetic resonance imaging (MRI). The public clinical trial is registered in Cuba (Number B‐10‐030‐L03). Adverse effects occurred in 75% of the cases, but they were mild. A significant reduction in the number of attacks, the disability scale score and the number of lesions at MRI were observed in patients with relapsing remitting MS treated with Rebif®. The use of interferon beta 1a showed safety and efficacy in the treatment of patients with relapsing remitting MS.
The Effect of CKD on Associations between Lifestyle Factors and All-cause, Cancer, and Cardiovascular Mortality: A Population-based Cohort Study

Objective Results from previous studies on the dose-dependent effect of adhering to multiple lifestyle factors on all-cause mortality in patients with chronic kidney disease (CKD) are inconsistent, despite the reported dose-dependent effect in the general population. This study aimed to examine whether CKD modifies the dose-dependent effect of adhering to multiple lifestyle factors on mortality. Methods This population-based prospective cohort study targeted 262,011 men and women aged 40-74 years at baseline. Of these, 18.5% had CKD, which was defined as GFR <60 mL/min/1.73 m2, ≥1+ proteinuria on urinalysis, or both. The following lifestyle behaviors were considered healthy: no smoking, body mass index <25 kg/m2, moderate or lower alcohol consumption, regular exercise, and healthy eating habits. Healthy lifestyle scores were calculated by adding the total number of lifestyle factors for which each participant was at low risk. Cox proportional hazards models were used to examine associations between healthy lifestyle scores and all-cause, cancer, and cardiovascular mortality, and whether CKD modified these associations. Results During a median follow-up of 4.7 years, 3,471 participants died. The risks of all-cause and cancer mortality decreased as the number of five healthy lifestyle factors that were adhered to increased, irrespective of the CKD status. The risk of cardiovascular mortality, however, was modified by CKD (interaction p=0.07), and an unhealthy lifestyle and CKD synergistically increased cardiovascular mortality. Conclusion A healthy lifestyle can reduce the risk of all-cause and cancer death in patients with or without CKD, while the prevention of CKD is essential for reducing the risk of cardiovascular death.
“I Don’t Know What to Say”: Teachers’ Perspectives on Supporting Bereaved Students After the Death of a Parent

This qualitative study examined teachers’ experiences dealing with bereaved students following the death of a parent. The researchers conducted in-depth, semi-structured, face-to-face interviews with 25 teachers in Israeli schools who had counseled one of their students after the death of a parent. The interviews were recorded and transcribed and underwent content analysis. Analysis of the findings revealed that the teachers felt helpless, confused, overloaded emotionally and anxious when counseling students who had lost a parent. In addition, the teachers discussed the complex nature of their relationship with the remaining parent, ranging from a desire to support the family through avoidance for fear of hurting the parent to fears of being overwhelmed by the child’s problems. Many teachers mentioned their need for support from school officials.
Training for videofluoroscopic swallowing analysis: A systematic review

Abstract Purpose To synthesise the available evidence relating to best practice in training videofluoroscopy and barium swallow analysts. Method The review was conducted according to the PRISMA statement and registered in PROSPERO (CRD42017053744). Data were extracted from nine databases. Studies were included if they described training approaches for clinicians or students of any profession learning to interpret videofluoroscopic (VFSS) or barium swallow studies and were written in English. The methods were heterogeneous and a metanalysis was not possible; a narrative review is presented. Result Sixteen studies were eligible, including those designed to evaluate the influence of training as well as those that described training as part of validating an assessment tool or method. The quality of the studies was assessed with the Hawker scale and assigned an NHMRC rating. While the evidence was low quality (NHMRC level IV), training consistently improved the accuracy and reliability of clinicians and students conducting VFSS. No studies reported the outcome of training for barium swallow analysis. There was significant variability in the dose, method, and setting of training. Conclusion To elucidate best practice in VFSS analysis to ensure training is cost effective and results in accurate diagnosticians requires further research.
Quantitative susceptibility-weighted imaging in amyotrophic lateral sclerosis with 3.0 T magnetic resonance imaging

Objective To evaluate alterations in phase-shift values in the gray matter of patients with amyotrophic lateral sclerosis (ALS) using susceptibility-weighted imaging (SWI). Methods Twenty patients with definite or probable ALS and 19 age- and sex-matched healthy controls were enrolled. SWI was performed using a 3.0 T magnetic resonance imaging scanner. Phase-shift values were measured in corrected phase images using regions of interest, which were placed on the bilateral precentral gyrus, frontal cortex, caudate nucleus, globus pallidus, and putamen. Results Phase-shift values of the precentral gyrus were significantly lower in ALS patients (−0.176 ± 0.050) than in the control group (−0.119 ± 0.016) on SWI. The average phase-shift values of the frontal cortex, caudate nucleus, globus pallidus, and putamen in ALS patients (−0.089 ± 0.023, −0.065 ± 0.016, −0.336 ± 0.191, and −0.227 ± 0.101, respectively) were not significantly different from those in the healthy controls (−0.885 ± 0.015, −0.079 ± 0.018, −0.329 ± 0.136, and −0.229 ± 0.083, respectively). Conclusions Compared with healthy controls, ALS patients had a lower phase-shift value in the precentral gyrus, which may be related to abnormal iron overload. Thus, SWI is a potential method for identifying ALS patients.
Efficacy and safety of dolutegravir plus lamivudine as a first-line regimen in clinical practice.

BACKGROUND The GEMINI trials have showed that the two drugs regimen of dolutegravir+lamivudine was non-inferior to a 3-drug regimen as a first line regimen for treatment-naïve PLWHIV. Aim of our study was to confirm, in a real-life setting, the efficacy of this regimen. MATERIALS AND METHODS We conducted a retrospective, observational study enrolling treatment-naïve patients starting a first-line regimen with lamivudine plus dolutegravir. We evaluated the virological efficacy and the immunological and metabolic profiles. Changes from baseline were evaluated via linear mixed models for repeated measures. Linear regression analyses were performed to explore variables associated to significant changes in laboratory parameters. RESULTS We analyzed a total of 20 patients: 15 (75%) were males with a median age of 34.5 years. During a cumulative time of 15.4 PYFU, we did not observe any adverse event or treatment discontinuation and all patients achieved virological suppression in the first 6 months from treatment initiation. Increase in CD4+ cells was significant at both week 24 (p=0.003) and week 48 (p=0.007) of follow-up. Moreover, CD4/CD8 ratio also significantly improved (median increase of +0.22 (p=0.028) after 48 weeks of follow-up. As to metabolic parameters, we observed no significant changes in total cholesterol, LDL cholesterol and HDL cholesterol. In a subgroup of 11 patients, we further investigate HIV-1 DNA variations. CONCLUSIONS Our results are in line with the findings of the GEMINI trials, confirming the efficacy and safety of DTG+3TC in treatment-naïve patients.
Insights into the role of placenta thickness as a predictive marker of perinatal outcome

The placenta is a transitory organ indispensable for normal fetal maturation and growth. Recognition of abnormal placental variants is important in clinical practice, and a broader understanding of the significance of placental variants would help clinicians better manage affected pregnancies. Increased thickness of the placenta is reported to be a nonspecific finding but it is associated with many maternal and fetal abnormalities, including preeclampsia and abnormal fetal growth. In this review, we address the questions regarding the characteristics of placenta thickness and the relationship between thickened placenta and poor pregnancy outcomes.
Relationship between PASI and FDLQI in paediatric psoriasis, and treatments used in daily clinical practice

Psoriasis is a chronic, inflammatory skin disease that affects 0.71% of children. Skin diseases can have a significant impact on quality of life not only for the children affected by psoriasis, but also for their parents and carers. This study aimed to achieve more insight into the quality of life (QOL) of family of paediatric patients with psoriasis, and to investigate whether disease severity scores correlate with Family Dermatology Life Quality Index (FDLQI) scores. In addition, we also observed the treatments used to treat paediatric psoriasis in daily clinical practice.
Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus

Age-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (LPD) occurs in elderly patients without immunodeficiency. An 81-year-old woman without any known immunodeficiency was examined for fever, rash, arthritis, thrombocytopenia, pleural and pericardial effusions, lymphadenopathy, and positive autoantibodies, which satisfied the classification criteria for systemic lupus erythematosus (SLE). However, a lymph node biopsy revealed EBV-LPD, and she was diagnosed with age-related EBV-LPD. In young individuals, EBV infection is a major differential diagnosis of SLE, but to our knowledge, this is the first reported case of age-related EBV-LPD mimicking SLE. We should therefore consider EBV-related disorders in the differential diagnosis of SLE even in elderly individuals.
Influence of age and maturation status on sprint acceleration characteristics in junior Australian football

ABSTRACT This study aimed to investigate the influence of chronological age and maturation status on sprint acceleration characteristics in junior Australian football (AF) players. Biological maturity of 109 subjects was assessed and subjects were grouped according to predicted years from peak height velocity (PHV) (pre-, mid-, and post-PHV) and chronological age (13 years, 14 years, and 15 years). A one-way multivariate analysis of variance and magnitude-based decisions were used to determine between-group differences. Instantaneous velocity was measured during two maximal 30m sprints via radar gun with the velocity-time data used to derive the force, velocity, and power characteristics. Chronologically, the greatest differences were observed between the 13 and 14 year old groups with the latter group producing likely greater relative maximum power (Pmax) (ES[effect size]=0.44) and theoretical maximal velocity (V0) (ES=0.49). The post-PHV group likely demonstrated a greater ability to apply force at faster velocity (V0; ES=0.59) and orient the force in a horizontal direction (Drf%; ES=-0.49) than the mid-PHV group. No differences in relative theoretical maximal force (F0) were observed between groups. Considering the findings, practitioners should aim to improve relative lower limb strength through heavy sled push or sled pulls and traditional strength training exercises to improve relative F0.
The mediating role of regulatory emotional self‐efficacy on negative emotions during the COVID‐19 pandemic: A cross‐sectional study

Abstract Nurses exposed to coronavirus disease 2019 (COVID‐19) are psychologically stressed. This study examines the characteristics and distribution of negative emotions among Chinese nurses during the COVID‐19 pandemic and explores regulatory emotional self‐efficacy (RESE) as the underlying mechanism in the relationship between nurses' personalities and negative emotions. A cross‐sectional design with convenience sampling was utilized. Three comprehensive tertiary hospitals located in China were selected. Nurses (n = 339) who cared for COVID‐19 patients were enrolled. Recruitment was conducted between 14 February 2020 and 1 March 2020. Self‐reported questionnaires about personality, RESE, and epidemic‐related negative emotions were completed online. A correlation analysis, structural equation modelling, and the bootstrapping method were used to analyse the data. This study identified a 24.9% incidence of negative emotions in nurses. RESE was a significant mediator explaining the effect of personality on epidemic‐related negative emotions. RESE mediated the effect of introversion–extroversion on depression (β = −0.151, P = 0.015), neuroticism (β = −0.182, P = 0.007), fear (β = −0.142, P = 0.006), anxiety (β = −0.189, P = 0.015), and hypochondria (β = −0.118, P = 0.010); it also mediated the effect of neuroticism on depression (β = 0.313, P = 0.002), neuroticism (β = 0.394, P = 0.003), fear (β = 0.345, P = 0.005), anxiety (β = 0.384, P = 0.003), and hypochondria (β = 0.259, P = 0.004). Nurses caring for COVID‐19 patients displayed negative emotions, particularly emotionally unstable and introverted nurses with a low RESE level. RESE is often essential for interventions because it significantly influences the relationship between personality and negative emotions. In the event of a major outbreak, tailored psychological well‐being education, which includes emotional self‐efficacy strategies, should be provided by organizations to help nurses manage stress related to the outbreak.
Normal stages of embryonic development of a brood parasite, the rosy bitterling Rhodeus ocellatus (Teleostei: Cypriniformes)

Bitterlings, a group of freshwater teleosts, provide a fascinating example among vertebrates of the evolution of brood parasitism. Their eggs are laid inside the gill chamber of their freshwater mussel hosts where they develop as brood parasites. Studies of the embryonic development of bitterlings are crucial in deciphering the evolution of their distinct early life‐history. Here, we have studied 255 embryos and larvae of the rosy bitterling (Rhodeus ocellatus) using in vitro fertilization and X‐ray microtomography (microCT). We describe 11 pre‐hatching and 13 post‐hatching developmental stages spanning the first 14 days of development, from fertilization to the free‐swimming stage. In contrast to previous developmental studies of various bitterling species, the staging system we describe is character‐based and therefore more compatible with the widely‐used stages described for zebrafish. Our bitterling data provide new insights into to the polarity of the chorion, and into notochord vacuolization and yolk sac extension in relation to body straightening. This study represents the first application of microCT scanning to bitterling development and provides one of the most detailed systematic descriptions of development in any teleost. Our staging series will be an important tool for heterochrony analysis and other comparative studies of teleost development, and may provide insight into the co‐evolution of brood parasitism.
Functional Tumor Volume by Fast Dynamic Contrast‐Enhanced MRI for Predicting Neoadjuvant Systemic Therapy Response in Triple‐Negative Breast Cancer

Dynamic contrast‐enhanced (DCE) MRI is useful for diagnosis and assessment of treatment response in breast cancer. Fast DCE MRI offers a higher sampling rate of contrast enhancement curves in comparison to conventional DCE MRI, potentially characterizing tumor perfusion kinetics more accurately for measurement of functional tumor volume (FTV) as a predictor of treatment response.
Work environment of hospital nurses during the COVID‐19 pandemic in Brazil

Aim To investigate the nurses' work environment in university hospitals during the COVID‐19 pandemic in Brazil. Background The COVID‐19 pandemic brought challenging times for nurses worldwide. In Brazil, as well as in several countries, nurses are working hard in hospital settings caring for patients infected with the virus, sometimes with unfavourable work environment conditions. Methods This study was a convergent embedded mixed methods research. The sample comprised 104 nurses from three Brazilian university hospitals. Data were collected in April–June 2020 from an online questionnaire with a self‐reporting Likert scale survey designed to measure the nurses' perceptions of their work environment. Qualitative data in the form of written comments were also collected through an open question. Data were analysed using descriptive statistics and content analysis. Results The quantitative results showed that the responses to ‘I received training on the correct use of personal protective equipment’ and ‘I am afraid of being infected’ items had the best and worst evaluations, respectively. The qualitative findings revealed five themes: feeling of insecurity, lack of personal protective equipment, lack of diagnostic tests, changes in the care flow and fear of the unknown. Conclusion The study has highlighted the challenges faced by hospital nurses while caring for patients with COVID‐19. Implications for Nursing and Nursing Policy The gaps identified will assist the policymakers and hospital managers in developing policies to enhance the support offered to nurses and improve the care provided to patients with COVID‐19 in university hospitals. The results also indicate the need for attention to the mental health of the professionals due to the increasing workload and treatment of an illness hitherto unknown.
Removal of aluminium by constructed wetlands with water hyacinth (Eichhornia crassipes (Mart.) Solms) grown under different nutritional conditions

This article reports the phytoremediation efficiencies of water hyacinth (Eichhornia crassipes (Mart.) Solms) grown under different nutritional conditions for Al rich wastewaters in batch type constructed wetlands (floating aquatic macrophyte-based plant treatment systems). This study was conducted for 15 weeks after 1 week acclimatization by culturing young water hyacinth (average height of 20 ± 2 cm) in 590 L capacity fiberglass tanks under different nutrient concentrations of 2-fold [56 and 15.4 mg/L of total nitrogen (TN) and total phosphorous (TP), respectively], 1-fold, 1/2-fold, 1/4-fold and 1/8-fold with synthetic wastewaters containing 5.62 Al mg/L. A control set-up of hyacinths comprising only Al with no nutrients was also studied. A mass balance was carried out to investigate the phytoremediation efficiencies and to identify the different Al removal mechanisms from the wastewaters. Chemical precipitation of Al(OH)3 was a dominant contribution to Al removal at the beginning of the study, whereas adsorption of Al3+ to sediments was observed to be a predominant Al removal mechanism as the study progressed. Phytoremediation mainly due to rhizofiltration was also an important mechanism of Al removal especially during the first 4 weeks of the study in almost all the set-ups. However, chemical precipitation and sediment adsorption of Al3 + was a dominant contribution to Al removal in comparison with phytoremediation. Plants cultured in the control set-up showed the highest phytoremediation efficiency of 63% during the period of the 4th week. A similar scenario was evident in the 1/8-fold set-up. Hence we conclude that water hyacinth grown under lower nutritional conditions are more ideal to commence a batch type constructed wetland treating Al rich wastewaters with a hydraulic retention time of approximately 4 weeks, after which a complete harvesting is recommended.
CA10 regulates neurexin heparan sulfate addition via a direct binding in the secretory pathway

Neurexins are presynaptic adhesion molecules that shape the molecular composition of synapses. Diversification of neurexins in numerous isoforms is believed to confer synapse‐specific properties by engaging with distinct ligands. For example, a subset of neurexin molecules carry a heparan sulfate (HS) glycosaminoglycan that controls ligand binding, but how this post‐translational modification is controlled is not known. Here, we observe that CA10, a ligand to neurexin in the secretory pathway, regulates neurexin‐HS formation. CA10 is exclusively found on non‐HS neurexin and CA10 expressed in neurons is sufficient to suppress HS addition and attenuate ligand binding and synapse formation induced by ligands known to recruit HS. This effect is mediated by a direct interaction in the secretory pathway that blocks the primary step of HS biosynthesis: xylosylation of the serine residue. NMR reveals that CA10 engages residues on either side of the serine that can be HS‐modified, suggesting that CA10 sterically blocks xylosyltransferase access in Golgi. These results suggest a mechanism for the regulation of HS on neurexins and exemplify a new mechanism to regulate site‐specific glycosylations.
NK cells in antibody‐mediated rejection – Key effector cells in microvascular graft damage

Antibody‐mediated rejection (ABMR) stands as the major limitation to long‐term transplant outcome. The immunologic understanding of ABMR continues to progress and has identified natural killer (NK) cells as key effector cells promoting and coordinating the immune attack on the graft microvascular endothelium. This review discusses the current concepts outlining the different ways that allow for NK cell recognition of graft endothelial cells which includes antibody‐dependent as well as independent processes.
Prevalence of Coxiella burnetii seropositivity and shedding in farm, pet and feral cats and associated risk factors in farm cats in Quebec, Canada

Abstract Cats represent a potential source of Coxiella burnetii, the aetiological agent of Q fever in humans. The prevalence and risk factors of C. burnetii infection in farm, pet and feral cats were studied in Quebec, Canada, using a cross-sectional study. Serum samples were tested using a specific enzyme-linked immunosorbent assay (ELISA) for the presence of antibodies against C. burnetii, whereas rectal swabs were assayed using real-time quantitative polymerase chain reaction (qPCR) for the molecular detection of the bacteria. Potential risk factors for farm cats were investigated using clinical examinations, questionnaires and results from a concurrent study on C. burnetii farm status. A total of 184 cats were tested: 59 from ruminant farms, 73 pets and 52 feral cats. Among farm cats, 2/59 (3.4%) were ELISA-positive, 3/59 (5.1%) were ELISA-doubtful and 1/59 (1.7%) was qPCR-positive. All pets and feral cats were negative to C. burnetii ELISA and qPCR. Farm cat positivity was associated with a positive C. burnetii status on the ruminant farm (prevalence ratio = 7.6, P = 0.03). Our results suggest that although pet and feral cats do not seem to pose a great C. burnetii risk to public health, more active care should be taken when in contact with cats from ruminant farms.