Miracle-dz/UniFAR-FTUs huggingface dataset:
RAAS inhibitors for hypertensive patients during Covid-19 infection – a metanalysis

Inhibition of the Renin Angiotensin Aldosterone system (RAAS) is the leading form of anti-hypertensive treatment, through blockade of the angiotensin-converting enzyme 2 receptor (ACE2-r) by angiotensin enzyme inhibitors (ACE-is) and angiotensin receptor blockers (ARBs). However, the ACE-r has been found to be a functional receptor for the viral entry of SARS-CoV-2, and increased upregulation of ACE2 by inhibitors could increase the severity of infection. Previous to the SARS-CoV-2 outbreak, typical practice in patients with risk of infection would be to withhold ACE inhibitors due to evidence of renal failure. This thesis reviews the impact of RAAS inhibitor use in COVID-19 patients, and if withholding ACE inhibitors could affect the clinical outcome of patients. A total of 22 studies were located form database searching (PubMed, MedRxiv, Google scholar), 15,784 hypertensive COVID-19 patients were documented, with 8,035 taking ACE-is/ARBs treatment in comparison to 7,024 without. RAAS inhibitors were found to decrease likelihood of mortality (OR 0.68 [0.51, 0.90], p = 0.008), but there was no statistically significant difference between RAAS and Non-RAAS in severity (OR 0.91 [0.63, 1.31], p= 0.62). Following these results there would not be sufficient evidence to remove longstanding RAAS inhibitor medication in COVID-19 patients. Rapid data collected during observational trials can now be utilised in long term randomised controlled studies currently ongoing, such as BRACE-CORONA. This allows the opportunity for further analyses of the association between the RAAS system, new variants, genetic polymorphism and the maintenance of blood pressure.
Documentation of the traditional Gayo food in Lokop Village, East Aceh, Indonesia

Abstract. Ramaidani, Navia ZI. 2022. Documentation of the traditional Gayo food in Lokop Village, East Aceh, Indonesia. Biodiversitas 23: 2017-2024. The Gayo Tribe community in Lokop Village, Serbajadi Sub-district, East Aceh, Indonesia, has known the traditional use of plants to meet food needs for a long time. However, this knowledge has not been widely documented. Therefore, it is necessary to conduct a study to document the typical food of the Gayo Tribe in Lokop Village, Serbajadi Sub-district, East Aceh, Indonesia. This study was conducted using the Snowball sampling method and semi-structured interviews involving 37 respondents. A total of 14 types of traditional Gayo food were documented, namely Cecah bajik, Cecah kekulit, Cecah ries, Jurung pengat, Masam jing, Apam, Berteh, Brahrum, Gutal, Lepat, Pulut berkerabu, Pulut manis, Pulut semplah, and Tumpi. In contrast, 52 plant species belonging to 46 genera and 31 families were used in traditional Gayo food. The most widely used family was Zingiberaceae with 5 species, the most widely used growth form was herb at 39%, and the most widely used plant parts were leaves and fruit, with 21% each. The frequency of using plants as the food was 100% for the species of Diplazium esculentum (Retz.) Sw. and Colocasia esculenta (L) Schott. The Gayo Tribe uses plants in their traditional food to contribute to economic value, health maintenance, and conservation efforts.
Cells during TLR9 Activation Up-Regulation in Plasmacytoid Dendritic Aging Impairs IFN Regulatory Factor 7

Plasmacytoid dendritic cells (pDCs) are innate sensors that produce IFN- (cid:1) in response to viral infections. Determining how aging alters the cellular and molecular function of these cells may provide an explanation of increased susceptibility of older people to viral infections. Hence, we examined whether aging critically impairs pDC function during infection with HSV-2, a viral pathogen that activates TLR9. We found that impaired IFN- (cid:1) production by aged murine pDCs led to impaired viral clearance with aging. Upon TLR9 activation, aged pDCs displayed defective up-regulation of IFN-regulatory factor 7, a key adaptor in the type I IFN pathway, as compared with younger counterparts. Aged pDCs had more oxidative stress, and reducing oxidative stress in aged pDCs partly recovered the age-induced IFN- (cid:1) defect during TLR9 activation. In sum, aging impairs the type I IFN pathway in pDCs, and this alteration may contribute to the increased susceptibility of older people to certain viral infections. The Journal of Immunology, 2008, 181: 6747–6756.
The Role of Type-2 Diabetes Mellitus in the Progressivity of Periodontitis Stage IV Grade C: A Case Report

Background: According to the American Academy of Periodontology (AAP)’s classification of periodontal disease in 2017, diabetes mellitus is one of the grade modifiers of the progressivity of the disease, which is determined by the HbA1c level of a patient. Systemic condition is often considered as a risk factor that aggravates periodontal tissue breakdown. However, the progressivity of periodontal disease can also be found in healthy (nondiabetic) patients. Objective: To identify the role of type-2 diabetes mellitus and its effect on the severity of periodontal breakdown in periodontitis stage 4 grade C patients. Case Report: This case report describes the condition of female patients, aged 30–40 years, who presented to the periodontology clinic in RSKGM FKG UI, with the chief complaint of severe tooth mobility. The patients reported were healthy and diabetic (type-2 diabetes mellitus) patients diagnosed with periodontitis stage 4 grade C. Initial therapies were carried out, such as, such as scaling, occlusal adjustment and dental splint. Results: Clinical outcomes after one week showed no inflammation, no oedematous, no redness on gingiva and less mobility on several teeth. Both groups showed extended and aggressive progress of the disease, however, the systemic conditions also played a critical role in the overall periodontal tissue breakdown. Conclusion: Management of systemic disease is crucial in order to prevent periodontal breakdown or complications that could happen in periodontal therapies. Keywords: periodontitis, systemic disease, diabetes mellitus, case report
Chemical and Bacteriological Evaluation of White Full Cream packed and Unpacked Soft Cheese

The aim of This work to evaluate chemical composition and bacteriological contamination of white full cream soft cheese. Twinty random samples of packed and unpacked (10 of each) white soft cheese were collected from different local markets at Kafr El Zayat cit,(EL-Gharbia Gov.), there were decreasing in protein content, volatile fatty acids and calcium % in unpacked white soft cheese with mean values (14.8 ± 1.9, 1.1 ± 0.03 and 7.4 ± 0.06) when comparison with mean values of packed soft white cheese ( 20.12 ±1.2, 1.7 ± 0.08 and 7.6 ± 0.04) respectively. The bacteriological examination revealed that there were a significance increase in total bacterial count, the Enterobacteriaceae, coliform count and staphylococci count in unpacked white soft cheese with mean values (7×10 5 ± 0.18, 3.12 ×10 3 ± 0.45, 1.27× 10 3 ± 0.1 and 3.44 ×10 3 ± 0.23) when comparison with mean values of packed soft cheese ( 3×10 3 ± 0.28, 2.05× 10 2 ±0.37, 1.42×10 2 ± 0.29 and 1.15×10 2 ± 0.26) respectively. Serological typing of E. coli strains of which isolated from unpacked soft white cheese in a percentages of 1% was belonged to O 119 : K 69 (B 19 ). No any samples examined was positive to staphylococcus aureus. The microbiological finding showed the presence of high counts of micro-organisms investigation and poor hygienic quality.
Management Transformation of Local Government In The New Normal Era

I Abstract : This study explores the implications of adapting new habits to the administration of local government from various dimensions of government management. The main objective of this study is to show that the governance of local government in the new normal era can be productive in fulfilling the needs of the publics through changes in the administration of local government’s functions. This study demonstrates the presence of information and communication technology (ICT) as well as restrictions on social interaction in the new normal era, changing the way local government sector works. The approach departs from the main idea of adapting new habits as a conceptual framework to empirically examine changes in the dimensions of local government management that are based on several factors, such as content, context, process, change outcomes and leadership. Furthermore, data collection gained through interviews with informants and data analysis are used to confirm the suitability of local government governance. The process is then carried on by formulating the concept of ideal local government governance changes in the new normal era. The findings of the study show that local government governance system with the old paradigm is ineffective and inefficient for the fulfillment of public rights in the new normal era. For this reason, it is necessary to transform the governance of various dimensions in local government management. As for originality/value, what is offered in this study is a modification of the system and working mechanism with a new paradigm for areas that are difficult geographically. This modification can be carried out in several actions, such as developing ICT applications and infrastructure; reorganizing the work system of all management dimensions that are trusted and accountable; increasing bureaucratic capacity and public knowledge; renewing the relationship between government and its people. This idea is relevant to the rapid development of the concept of adaptive governance and the strength of the role of ICT for individual and social activities.
Psychometric properties of the Serbian version of Mental Toughness Inventory and Dark Triad Dirty Dozen in police students

Police work is a stressful occupation, where officers are exposed to chronic and intense stressors. When it comes to understanding and predicting reaction to prolonged stress, it has been shown that there is more to personality than what can be captured by the most widespread personality models. Adding Mental Toughness as the capacity to tolerate and overcome stress at work, as well as the Dark Triad as a tendency for malevolent behaviour, to the traditional model of assessing the personality of a police officer can improve the prediction of important outcomes. The aim of this paper was to examine the psychometric properties of the Serbian translations for the Mental Toughness Inventory (MTI) and the Dark Triad Dirty Dozen (DTDD) in a population of police students. The research was conducted on a sample of 92 students in their first and second years at the University of Criminal Investigation and Police Studies. Considering the specificity of the sample, both instruments showed good reliability (Cronbach's Alpha Based on Standardized Item a = 0.81 for MTI and a = 0.84 for DDTD); factor structure was confirmed for the MTI (ch² = 51.5, p < 0.001, CFI = 0.864) and DTDD (ch² = 105, p < 0.001, CFI = 0.886) as well as convergent (r=-.384, p < 0.01 between Mental toughness, and Machiavellianism). Although deviations from the normal distribution were obtained, having in mind the rigor of psychological and physical selection into the Police University, the obtained psychometric properties of the MTI and DTDD were acceptable and we recommend the instruments for further usage.
The Leading Role of the Immune Microenvironment in Multiple Myeloma: A New Target with a Great Prognostic and Clinical Value

Multiple myeloma (MM) is a plasma cell (PC) malignancy whose development flourishes in the bone marrow microenvironment (BMME). The BMME components’ immunoediting may foster MM progression by favoring initial immunotolerance and subsequent tumor cell escape from immune surveillance. In this dynamic process, immune effector cells are silenced and become progressively anergic, thus contributing to explaining the mechanisms of drug resistance in unresponsive and relapsed MM patients. Besides traditional treatments, several new strategies seek to re-establish the immunological balance in the BMME, especially in already-treated MM patients, by targeting key components of the immunoediting process. Immune checkpoints, such as CXCR4, T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), PD-1, and CTLA-4, have been identified as common immunotolerance steps for immunotherapy. B-cell maturation antigen (BCMA), expressed on MMPCs, is a target for CAR-T cell therapy, antibody-(Ab) drug conjugates (ADCs), and bispecific mAbs. Approved anti-CD38 (daratumumab, isatuximab), anti-VLA4 (natalizumab), and anti-SLAMF7 (elotuzumab) mAbs interfere with immunoediting pathways. New experimental drugs currently being evaluated (CD137 blockers, MSC-derived microvesicle blockers, CSF-1/CSF-1R system blockers, and Th17/IL-17/IL-17R blockers) or already approved (denosumab and bisphosphonates) may help slow down immune escape and disease progression. Thus, the identification of deregulated mechanisms may identify novel immunotherapeutic approaches to improve MM patients’ outcomes.
miR-141-3p Regulates EZH2 to Attenuate Porphyromonas gingivalis Lipopolysaccharide-Caused Inflammation and Inhibition of Osteogenic Differentiation in Human Periodontal Ligament Stem Cells

Objective miR-141-3p has been demonstrated to be both anti-inflammatory and osteoprotective. This study is aimed at investigating the effect of miR-141-3p on osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) stimulated by Porphyromonas gingivalis lipopolysaccharide (PgLPS) and its mechanism. Methods PgLPS was used to induce an inflammatory environment, and overexpression of miR-141-3p was done to assess its effect on hPDLSCs in an inflammatory environment. The level of miR-141-3p and EZH2 in hPDLSCs from each treatment group was detected via qRT-PCR, and the inflammatory factors IL-6 and IL-8 in the supernatant of each group were detected by ELISA. ALP staining and alizarin red staining were used to assess the effect of miR-141-3p on the osteogenic differentiation ability of hPDLSCs, and also, western blot was used to detect expression of osteogenic differentiation-related proteins. Further, dual-luciferase reporter assay examined whether miR-141-3p targeted EZH2. Results PgLPS led to a significant decrease of miR-141-3p in hPDLSCs. Overexpression of miR-141-3p could enhance ALP activity and alizarin red staining intensity and increase Runx2, OPN and OCN protein expression levels in PgLPS-treated hPDLSCs. Additionally, miR-141-3p could reduce IL-6 and IL-8. miR-141-3p could target and negatively regulate EZH2, and overexpression of EZH2 reversed the promoting effect of miR-141-3p on osteogenic differentiation. Conclusion miR-141-3p can attenuate PgLPS-induced inhibition of osteogenic differentiation and inflammation in hPDLSCs by negatively regulating EZH2.
Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil

Seeds of cumin (Cuminum cyminum L.) are widely used as a spice for their distinctive aroma. C. cyminum have been used in traditional medicine to treat a variety of diseases. Literature presents ample evidence for biomedical activities of cumin which is attributed to its bioactive secondary metabolites - terpenes, phenols, and flavonoids. Besides, health effects of cumin seeds have been experimentally validated through phytochemical analysis depicting the presence of a wide array of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinone, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Pharmacological studies indicate that BASMs in seeds of C. cyminum exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. In the present study phytochemical screening, GCMS, FTIR profile of bioactive natural products from C. cyminum has been envisaged. Phytochemical screening revealed the presence of alkaloids, anthraquinones, carbohydrates, coumarins, flavonoids, glycosides, proteins, quinones, saponins, steroids, tannins and terpenoids. GC-MS analysis revealed the presence of 21 compounds, of which Cuminaldehyde was prominent. FTIR analysis showed the presence of a strong peak value for 15 compounds and medium peak value for 6 compounds. Many of the compounds in the list could be ADMET bioprospected for biomedical applications as natural drug leads. Keywords: Cuminum cyminum; Cuminaldehyde; Bioactive Natural Products; GCMS; FTIR
FACTORS AFFECTING EMPLOYER SATISFACTION ON MEETING GRADUATES’ JOB REQUIREMENTS OF TEACHER TRAINING DISCIPLINES

Đào tạo sinh viên tốt nghiệp có khả năng đáp ứng tốt yêu cầu công việc sau khi được tuyển dụng là một vấn đề quan trọng đối với các cơ sở giáo dục đại học. Mục đích của bài viết này nhằm xác định và phân tích các yếu tố ảnh hưởng đến sự hài lòng của nhà sử dụng lao động về khả năng đáp ứng yêu cầu công việc của sinh viên tốt nghiệp các ngành đào tạo giáo viên của Trường Đại học Đồng Tháp. Dữ liệu được sử dụng trong nghiên cứu này là phản hồi của 201 nhà sử dụng lao động đang là cán bộ quản lý tại các trường mầm non, tiểu học, trung học cơ sở, trung học phổ thông. Kết quả phân tích nhân tố khám phá và hồi quy tuyến tính đã chỉ ra 03 nhân tố có ảnh hưởng đến sự hài lòng của nhà sử dụng lao động về khả năng đáp ứng yêu cầu công việc của sinh viên tốt nghiệp. Mức độ ảnh hưởng của từng nhân tố đến sự hài lòng của các nhà sử dụng lao động lần lượt là thái độ làm việc, kỹ năng chuyên môn và kỹ năng mềm của sinh viên tốt nghiệp. Kết quả nghiên cứu là cơ sở quan trọng để Trường Đại học Đồng Tháp cập nhật và phát triển các chương trình đào tạo giáo viên đáp ứng tốt hơn yêu cầu của xã hội.
Use of digital technologies in the cardiopulmonary resuscitation teaching-learning process: an integrative review

Objective: The aim was to identify the scientific evidence available in the literature on the use of digital technologies for the teaching and learning of cardiopulmonary resuscitation. Method: Integrative literature review performed on the PubMed, CINAHL, Scopus, SciELO and LILACS databases. One hundred six studies were identified and of these, only eight made up the sample. Results: The main technologies identified and considered effective were virtual simulators, online courses, Telegram and HeartCode™, involving affective, cognitive and psychomotor skills. Virtual simulation was the most adopted and effective for the development of cognitive, psychomotor and affective skills. Conclusion: This study contributes to research, teaching and care by presenting a framework of scientific evidence related to the articulation of digital technologies and the teaching of cardiopulmonary resuscitation, exposing digital pedagogical possibilities for the best practices and de-velopment of cognitive, psychomotor and affective skills.
Estimation of Winter Wheat Residue Coverage Based on GF-1 Imagery and Machine Learning Algorithm

Crop residue is an important component of farmland ecosystems, which is of great significance for increasing soil organic carbon, mitigating wind erosion and water erosion and conserving soil and water. Crop residue coverage (CRC) is an important parameter to characterize the number and distribution of crop residues, and also a key indicator of conservation tillage. In this study, the CRC of wheat was taken as the research object. Based on the high-resolution GF-1 satellite remote sensing imagery from China, decision tree (DT), gradient boosting decision tree (GBDT), random forest (RF), least absolute shrinkage and selection operator (LASSO), extreme gradient boosting regression (XGBR) and other machine learning algorithms were used to carry out the estimation of wheat CRC by remote sensing. In addition, the comparisons with sentinel-2 imagery data were also utilized to assess the potential of GF satellite data for CRC estimates. The results show the following: (1) Among the spectral indexes using shortwave infrared characteristic bands from sentinel-2 imagery, the dead fuel index (DFI) was the best for estimating wheat CRC, with an R2 of 0.54 and an RMSE of 10.26%. The ratio vegetation index (RVI) extracted from visible and near-infrared characteristic bands from GF-1 data performed the best, with an R2 of 0.46 and an RMSE of 11.39%. The spectral index extracted from GF-1 and sentinel-2 images had a significant response relationship with wheat residue coverage. (2) When only the characteristic bands from the visible and near-infrared spectral ranges were applied, the effects of the spatial resolution differences of different images on wheat CRC had to be taken into account. The estimations of wheat CRC with the high-resolution GF-1 data were significantly better than those with the Sentinel-2 data, and among multiple machine learning algorithms adopted to estimate wheat CRC, LASSO had the most stable capability, with an R2 of 0.46 and an RMSE of 11.4%. This indicates that GF-1 high-resolution satellite imagery without shortwave infrared bands has a good potential in applications of monitoring crop residue coverage for wheat, and the relevant technology and method can also provide a useful reference for CRC estimates of other crops.
Histopathological and reproductive effect of tamsulosin and finasteride on induced Benign prostate hyperplasia in mice

The prostate hyperplasia (BPH) was induced in male mice by subcutaneous injection of testosterone propionate (20 mg/kg) for 30 days. Fifty mice were divided equally into five groups, the first group (G1) was (negative control group), and the second group (G2) was (positive Control group) induced BPH previously and inoculated orally distilled water. The third group (G3) was induced BPH and treated orally with tamsulosin (0.156mg /kg), the fourth group (G4) was induced BPH and treated orally with Finasteride (1.495 mg /kg) and finally, the fifth (G5) was induced BPH and treated orally with a combination of tamsulosin and finasteride (0.0825, 0.7475) mg/kg respectively. The histopathological results showed prostate hyperplasia and abnormal proliferation of the epithelial and stromal cells with inflammation cells accompanying stenosis of acini in G2. Whereas showed a decrease in hyperplasia, and epithelial layer thickness in G3 and G4. Furthermore, prostate shrinkage and the glandular cavities trended towards the normal approach of the prostate in G5. The testosterone levels in G2 showed a significant increase (P<0.05) as compared to other treated groups with a more significant decrease in G4 compared to other treated groups.
Use of geotechnologies for morphometric analysis of experimental basin in the semiarid region to support hydrological simulation

The morphometric characteristics help to regulate the hydrological processes of a basin. The understanding of these characteristics is essential for an adequate planning of water resources. The aim of this study was to analyze the sensitivity of the hydrological simulation to different pixel thresholds for the generation of the drainage network and to perform a detailed morphometric characterization of the sub-basin upstream of a fluviometric section (SBSF) installed in the experimental basin of the Jatobá stream, semiarid region of Pernambuco. The following thresholds were considered: 264, 132, 66, 55 and 44 pixels, corresponding to scenarios 1 to 5, respectively. The morphometric analyses were performed through hydrological modeling and the use of mathematical equations, where 25 morphometric indices were evaluated. The results indicated that scenarios 3, 4 and 5 adequately represented the hydrological processes. The physical parameters indicate that the basin has an elongated shape, with a low tendency for flood peaks under normal conditions of climatic events. Although the SBSF presents a low average slope, it was verified the existence of regions with high slopes, favoring the surface runoff, which requires the adoption of conservationist practices and the maintenance of native vegetation.