Miracle-dz/UniFAR-FTUs huggingface dataset:
Resting activity of the hippocampus and amygdala in obese individuals predicts their response to food cues

Obese individuals exhibit brain functional abnormalities in multiple regions implicated in reward/motivation, emotion/memory, homeostatic regulation, and executive control when exposed to food cues and during rest. However, it remains unclear whether abnormal brain responses to food cues might account for or relate to their abnormal activity in resting state. This information would be useful for understanding the neural mechanisms behind hyperactive responses to food cues, a critical marker of obesity. Resting‐state functional magnetic resonance imaging (RS‐fMRI) and a cue‐reactivity fMRI task with high‐ (HiCal) and low‐caloric (LoCal) food cues were employed to investigate brain baseline activity and food cue‐induced activation differences in 44 obese participants (OB), in 37 overweight participants (OW), and in 37 normal weight (NW) controls. One‐way analyses of variance showed there was a group difference in the left hippocampus/amygdala activity during resting state and during food‐cue stimulation (pFWE < 0.05); post‐hoc tests showed the OB group had both greater basal activity and greater food cue‐induced activation than the OW and NW groups; OW had higher activity in the hippocampus/amygdala than the NW group, which was only significant during resting state. In the OB group, resting‐state activity in the left hippocampus/amygdala was positively correlated with activation induced by HiCal food cues, and both of these measures correlated with body mass index (BMI). Mediation analysis showed that the relationship between BMI and hippocampus/amygdala response to HiCal food cues was mediated by their resting‐state activity. These findings suggest a close association between obesity and brain functional abnormality in the hippocampus/amygdala. They also indicate that resting‐state activity in the hippocampus/amygdala may impact these regions' responses to food cues.
High intratumoral CD8+ T‐cell infiltration is associated with improved survival in prostate cancer patients undergoing radical prostatectomy

A high density of CD8+ tumor infiltrating lymphocytes (TILs) is associated with improved survival in multiple cancers, but its prognostic role in prostate cancer remains controversial. The aim of our study was to evaluate the prognostic value of CD8+ TILs in prostate cancer patients undergoing radical prostatectomy (RP). We hypothesized that elevated density of CD8+ TILs in the RP specimen would correlate with improved clinical outcomes. This information may be helpful for future immunotherapy clinical trial design and treatment selection.
Primary aeromedical retrieval crew composition: Do different teams impact clinical outcomes? A descriptive systematic review.

OBJECTIVES Military Forward Aeromedical Evacuation and civilian Helicopter Emergency Medical Services are widely used to conduct Primary Aeromedical Retrieval. Crew composition in Primary Aeromedical Retrieval missions varies considerably. The ideal composition is unknown. Thus, we conducted a descriptive systematic review on mortality and other outcomes for different Primary Aeromedical Retrieval crew compositions. METHODS Medline, Embase, and Cochrane Controlled Trials Register were searched up to January 2020. Results were reported per Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Studies of adult trauma air transported by different crews were included. Population, injury severity, crew composition, procedures, and outcomes, including mortality, were abstracted. Risk of bias was assessed using previously validated tools. A lack of reported effect measures precluded a quantitative analysis. RESULTS Sixteen studies met inclusion criteria (3 prospective studies, 1 case-control, and 12 retrospective). Overall, studies reported a mortality benefit associated with advanced health care providers. This was most apparent in patients with severe but survivable injuries. In this population, early rapid sequence induction, endotracheal intubation, mechanical ventilation, thoracostomies, blood products transfusion, and treatment of hemorrhagic shock are better performed by advanced providers and may improve outcomes. The quality of evidence reported a moderate risk of bias in the included studies. CONCLUSIONS Overall, findings were divergent but showed a trend to decreased mortality in patients treated by advanced providers with interventions beyond the basic paramedic level. This trend was most significant in patients with severe but survivable injuries. These results should be cautiously interpreted because most studies were observational, had small sample sizes, and had a high potential for confounding factors.
A new species of Croton sect. Luntia (Euphorbiaceae) from western Amazonian Brazil

A new species of Croton, C. subasperrimus, is described and illustrated from a previously unexplored area of Amazonas State, Brazil. It belongs to Croton sect. Luntia subsect. Cuneati because of its pinnate leaf venation, slightly reduplicate pistillate calyx, partially bisexual basal cymules, presence of lepidote trichomes, low stamen number, and multifid stigmas. It differs from related species in its stellate-lepidote trichomes that sometimes have tall porrect central rays and in its smaller, concolorous leaves with an obtuse base and stipitate glands along the margins.
Applicability of Equilibrium Sampling in Informing Tissue Residues and Dietary Risks of Legacy and Current‐Use Organic Chemicals in Aquaculture

Equilibrium sampling based on silicone polydimethylsiloxane (PDMS) has been used to determine the concentrations of freely dissolved hydrophobic organic compounds (HOCs) and assess the thermodynamic potentials for bioaccumulation of these compounds in the aquatic environment. This allows the use of PDMS‐based sampling techniques in assisting conventional sampling and extraction methods for the determination of the concentrations of HOCs in aquaculture products. The present study is an ex situ demonstration of how well PDMS can inform the tissue residues and dietary risks of legacy or current‐use organic chemicals in aquaculture species from farm ponds in eastern China. For legacy contaminants such as polybrominated diphenyl ethers (PBDEs, n = 10), good agreement between the predicted concentrations based on PDMS and the measured lipid‐normalized concentrations was observed for 60% of the studied biota, including both pelagic and benthic species. For pesticides currently used, such as pyrethroid (PE) (n = 4) and organophosphate pesticides (OPPs, n = 7), the measured tissue residues were consistently higher than those predicted by PDMS, possibly caused by the continuous input from the surroundings. For the organochlorine pesticides (OCPs, n = 5), the only detected chemical was also underestimated. Adjusted by ingestion rates of aquaculture products and toxicology data, the target hazard quotients of these chemicals predicted from PDMS were generally comparable to those derived from measured concentrations in tissue because of the predominance of PBDEs. Overall, PDMS‐based equilibrium sampling offered an alternative approach for the prediction of tissue residues and dietary risks of PBDEs. Moreover, it should be applied with caution for PEs, OPPs, and OCPs. Improving the application of PDMS for these chemicals in farm ponds warrants future study. Environ Toxicol Chem 2021;40:79–87. © 2020 SETAC
Investigation of Interface Thermal Resistance between Polymer and Mold Insert in Micro-Injection Molding by Non-Equilibrium Molecular Dynamics

Micro-injection molding has attracted a wide range of research interests to fabricate polymer products with nanostructures for its advantages of cheap and fast production. The heat transfer between the polymer and the mold insert is important to the performance of products. In this study, the interface thermal resistance (ITR) between the polypropylene (PP) layer and the nickel (Ni) mold insert layer in micro-injection molding was studied by using the method of non-equilibrium molecular dynamics (NEMD) simulation. The relationships among the ITR, the temperature, the packing pressure, the interface morphology, and the interface interaction were investigated. The simulation results showed that the ITR decreased obviously with the increase of the temperature, the packing pressure and the interface interaction. Both rectangle and triangle interface morphologies could enhance the heat transfer compared with the smooth interface. Moreover, the ITR of triangle interface was higher than that of rectangle interface. Based on the analysis of phonon density of states (DOS) for PP-Ni system, it was found that the mismatch between the phonon DOS of the PP atoms and Ni atoms was the main cause of the interface resistance. The frequency distribution of phonon DOS also affected the interface resistance.
INDUCED MUTAGENESIS IN COWPEA. [Vigna unguiculata (L.) Walp.]

The present investigation on cowpea [Vigna unguiculata (L.) Walp. ] var. Pusa Phalguni was undertaken to find out the amount and types of variability induced by different doses and concentrations of three mutagens, one physical viz., Gamma rays and two chemical mutagens viz., EMS (ethyl methane sulfonate C3H8O3S) and 5-Bromouracil. The study was carried out at Main Vegetable Research Station, A.A. U. , Anand. The seeds were exposed to 30, 40 and 50 kR of gamma rays and another lot of seeds was treated with three concentrations each of EMS and 5-Bromouracil i.e. 0.1, 0.2 and 0.3 per cent. The M1 generation was raised during February (2008) and M2 generation was raised on 5th September 2008 in Randomized Block Design with four replications and ten treatments. ii In M2 generation, observations were recorded from fifteen sample plants/plot for twelve important characters viz., days to 1st flowering, days to 50 % flowering, days to maturity, plant height, number of branches per plant, number of pods per plant, pod length, number of seeds per pod, dry pod yield per plant, dry seed yield per plant, seed test weight and protein per cent. Out of 12 characters studied, mutagenic treatments created significant variability for six characters viz., plant height, number of branches per plant, number of pods per plant, dry pod yield per plant, dry seed yield per plant and protein per cent. For the three important phenological traits, treatment T1 (30 kR gamma rays) showed some variability towards earliness, but was found to be non significant. Mean values were found significant for agromorphological traits viz., plant height, number of branches per plant and number of pods per plant. Treatment T2 (40 kR gamma rays) was found effective in increasing plant height. There was increase in number of branches per plant due to treatment T3 (50 kR gamma rays). T6 (0.3 % EMS) was found to be effective in creating significant variability in number of pods per plant. Treatment T4 (0.1% EMS) was found to be significantly superior among all the treatments for both
Nestling diet and fledgling production of Eurasian kestrels (Falco tinnunculus) in eastern Spain

--We studied 81 Eurasian kestrel (Falco tinnunculus) nests in the Alto Palancia region (Castel16n, eastern Spain) from 1982-87. Fledgling production was recorded in routine visits to the nests, and the diet was determined by pellet analysis. The mean date of laying was 8 May (N -24, SD -11.5), similar to that of populations breeding further north in Europe. On average, each successful pair produced four fledglings per year (N = 47, SD = 0.7, range = 2-5), and no significant differences in fledging success were found among years. Grasshoppers formed the bulk of the diet during the nestling period. Mammals and birds were scarcely represented. The number of fledglings per successful pair was similar to or higher than that reported from Finland, Germany, and England where voles are the main prey brought to the nestlings. We suggest that a relative abundance of insects, and reduced energy requirements for thermoregulation i Mediterranean areas allow kestrels to successfully feed their young mainly on insects, without reducing fledgling production in relation to populations where voles form the bulk of the nestling diet.
Gianturco Z-stent placement for the treatment of chronic central venous occlusive disease: implantation of 208 stents in 137 symptomatic patients.

PURPOSE To report the technical successes, adverse events, and long-term stent patency rates of Gianturco Z-stents for management of chronic central venous occlusive disease. METHODS Overall, 137 patients, with mean age 48.6±16.1 years (range, 16-89 years), underwent placement of Gianturco Z-stents for chronic central venous occlusions. Presenting symptoms included lower extremity edema (n=66, 48.2%), superior vena cava syndrome (n=30, 21.9%), unilateral upper extremity swelling (n=20, 14.6%), hemodialysis fistula or catheter dysfunction (n=11, 8.0%), ascites (n=8, 5.8%), and both ascites and lower extremity edema (n=2, 1.5%). Most common etiologies of central venous occlusion were prior central venous access placement (n=58, 42.3%), extrinsic compression (n=29, 21.2%), and post-surgical anastomotic stenosis (n=27, 19.7%). Number of stents placed, stent implantation location, stent sizes, technical successes, adverse events, need for re-intervention, follow-up evaluation, stent patencies, and mortality were recorded. Technical success was defined as recanalization and stent reconstruction with restoration of in-line venous flow. Adverse events were defined by the Society of Interventional Radiology Adverse Event Classification criteria. Primary and primary-assisted stent patencies were analyzed using Kaplan-Meier analysis. RESULTS In total, 208 Z-stents were placed. The three most common placement sites were the inferior vena cava (n=124, 59.6%), superior vena cava (n=44, 21.2%), and brachiocephalic veins (n=27, 13.0%). Technical success was achieved in 133 patients (97.1%). There were two (1.5%) severe adverse events (two cases of stent migration to the right atrium), one (0.7%) moderate adverse event, and one (0.7%) mild adverse event. Mean follow-up was 43.6±52.7 months. Estimated 1-, 3-, and 5-year primary stent patency was 84.2%, 84.2%, and 82.1%, respectively. Estimated 1-, 3-, and 5-year primary-assisted patency was 92.3%, 89.6%, and 89.6%, respectively. The 30- and 60- day mortality rates were 2.9% (n=4) and 5.1% (n=7), none of which were directly attributable to Z-stent placement. CONCLUSION Gianturco Z-stent placement is safe and effective for the treatment for chronic central venous occlusive disease with durable short- and long-term patencies.
Part 4: Pediatric Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.

Alexis A. Topjian, MD, MSCE, Chair; Tia T. Raymond, MD, Vice-Chair; Dianne Atkins, MD; Melissa Chan, MD; Jonathan P. Duff, MD, Med; Benny L. Joyner Jr, MD, MPH; Javier J. Lasa, MD; Eric J. Lavonas, MD, MS; Arielle Levy, MD, Med; Melissa Mahgoub, PhD; Garth D. Meckler, MD, MSHS; Kathryn E. Roberts, MSN, RN; Robert M. Sutton, MD, MSCE; Stephen M. Schexnayder, MD; On behalf of the Pediatric Basic and Advanced Life Support Collaborators
Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease

Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline. Surface electroencephalogram spikes and intracranial recordings of nocturnal silent seizures in human AD, coupled with the abnormal neural synchrony that precedes development of behavioral seizures in mouse AD models, build the case for epileptogenesis as an early therapeutic target for AD. Since most individuals with AD do not develop overt seizures, leveraging functional biomarkers of epilepsy risk to stratify a heterogeneous AD patient population for treatment is research priority for successful clinical trial design. Who will benefit from antiseizure interventions, which one, and when should it begin?
Correlation of Escherichia coli Strains Isolated from Wild Bird Feces and Human Urinary Tract Infections from Phylogenetic Point of View

Background: Escherichia coliis a typical occupant of the enteric system of vertebrates. Some E. coli strains are related to urinary tract infections (UTIs) in human. E. coli strains are divided namely to the four phylogenetic groups, A, B1, B2, and D. Some investigations have indicated the relationship between phylogenetic characteristics and pathogenicity of E. coli. Thus, determining the phylogeny of unknown E. coli strains may be useful in predicting the pathogenesis. Objectives: In the present study, we aimed to compare the distribution of E. coli phylogroups in human UTIs and wild bird feces as a possible source of infection for human in a cross-sectional survey. Methods: A total of 264 E. coli isolates were obtained from human UTIs and feces of wild birds around and phylogenetic determination was carried out using the Clermont Triplex-PCR technique. Results: Our results showed that phylogenetic group B2 strains were the most prevalent in UTI cases (47.2%) followed by group D (30.2%). Group B1 contained 32.5% of the isolates in feces of wild birds, followed by group A (27.5%). There was a significant difference in E. coli phylogeny between hosts so that groups B2 and D were more prevalent in human UTIs and groups B1 and A in wild birds. Also, when comparing the phylogroups within a host, group B1 showed a higher rate in wild birds than in human UTIs. Conclusions: Although the majority of isolates from wild birds belonged to nonpathogenic phylogenetic groups B1 and A, further research seems to necessary to assess the exact relation of wild birds as pathogen sources for human by genotyping E. coli strains via high throughput genotyping assays.
Mucosal‐Associated Invariant T Cell Dysregulation Correlates With Conjugated Bilirubin Level in Chronic HBV Infection

Mucosal‐associated invariant T (MAIT) cells are nonconventional T cells restricted to major histocompatibility complex class I–related protein 1 (MR1). They are highly abundant in human liver and activated by T‐cell receptor (TCR)‐dependent and TCR‐independent mechanisms to exhibit rapid, innate‐like effector responses. However, the roles of MAIT cells in chronic HBV infection are still open for study. This study aims to test their antiviral potential and investigate their dynamic changes and regulating factors during chronic HBV infection.
Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19

Abstract Rationale: The new coronavirus pneumonia Corona Virus Disease 2019 (COVID-19) has become a global pandemic. Patients with critically COVID-19 usually require invasive respiratory support, and the airway management is particularly important and the prognosis is poor. Patient concerns: A 64-year-old man with an anastomotic fistula after radical treatment of esophageal cancer and right-side encapsulated pyopneumothorax was admitted with cough and dyspnea. Diagnosis: The patient was diagnosed with novel coronavirus pneumonia and right-side encapsulated pyopneumothorax by pharyngeal swab nucleic acid test in combination with chest computed tomography (CT). Interventions: The patient was treated with antibiotics, antiviral and antibacterial medications, respiratory support, expectorant nebulization, and nutritional support. But he expressed progressive deterioration. Endotracheal intubation and mechanical ventilation were performed since the onset of the type - respiratory failure on the 13th day of admission. The patient had persistent refractory hypercapnia after mechanical ventilation. Based on the treatment mentioned above, combined with repeated bronchoalveolar lavage by using N-acetylcysteine (NAC) inhalation solution, the patients refractory hypercapnia was gradually improved. Outcomes: The patient was cured and discharged after being given the mechanical ventilation for 26 days as well as 46 days of hospitalization, currently is surviving well. Lessons : Patients with severe conditions of novel coronavirus pneumonia often encounter bacterial infection in their later illness-stages. They may suffer respiratory failure and refractory hypercapnia that is difficult to improve due to excessive mucus secretion leading to small airway obstruction. This study provided a new insight on the proper treatment severe COVID-19 patients. The use of reasonable antibiotics and symptomatic respiratory support and other treatment, timely artificial airway and repeated bronchoalveolar NAC inhalation solution lavage, expectorant and other airway management are essential for such patients.
Fiction as a Means for Understanding the Dynamics of Empathy: A 3- year Empirical Study with Students

The current study investigated whether the reflective reading of fiction can provide an experiential definition of empathy to supplement more traditional concept analyses. A secondary aim was to look at the rates of absorption (loss of time and space) relative to the rate of reported empathic engagement. Based on earlier studies on reading fiction as an engagement in a social simulation, it was predicted that because fiction is a controlled experience, reading and talking about fiction could provide a forum in which to examine actual experiences of empathy elicitation in relation to an evolving situation. A survey was conducted with 210 student participants over a three-year period. The results show that the empathetic response to narrative is affected in a variety of ways by the presence or absence of an initial sense of affinity and by cognitive input over time, that is, the changing perception of characters and the situations with which they are confronted. Adept readers are more likely to experience absorption, and those who experience absorption are more likely to be empathetically responsive to input and changes in a situation. Empathetic emotions and cognitive empathy can be experienced for multiple objects simultaneously in one situation and relate to past events and potential futures, but they also shift from object to object.
Effect of Parity on Productive Performance and Calving Interval in Water Buffaloes

The aim of this study was to determine the effect of the parity on productive performance (lactation length, total milk yield and milk yield by day of calving interval) and calving interval in water buffaloes. For this purpose, records of 663 lactations from 248 buffaloes were evaluated. Total milk yield was 1344.91 liters, lactation length was 291.20 days, calving interval was 453.55 days and milk by day of calving was 2.77 liters. Parity did not significantly affect total milk yield, but had a significant effect on lactation length, calving interval and milk by day of calving interval. First calving buffaloes had a longer lactation, a longer calving interval and in consequence lower productivity than buffaloes with two and three or more calving. Second calving buffaloes had intermediate and significantly different values than buffaloes with three or more calving. Calving interval was positively correlated with total milk yield (r = 0.34983, p <0.0001) and length of lactation (r = 0.67408, p = <0.0001); and negatively with milk by day of calving (r = -0.41263, p<0.0001). In conclusion, parity affected the productive performance and calving interval, with buffaloes of one and two calving being less productive due to a longer calving interval. An increase of milk yield is related with a longer calving interval, therefore, buffaloes of one and two calving, must be provided with optimal management conditions, which allow them to support milk yield and not to compromise the reproductive performance.