Miracle-dz/UniFAR-FTUs huggingface dataset:
Case Report: Pediatric Renal Sarcoidosis and Prognostic Factors in Reviewed Cases

Background: Pediatric sarcoidosis is a complex inflammatory disorder with multisystemic manifestations. Kidney involvement in children is rare, and prognostic factors are unknown. Case Report and Methods: We report the case of a 16-year-old girl with multiorgan sarcoidosis and renal involvement. The patient presented with tubulointerstitial nephritis, acute kidney injury (AKI), chest CT disseminated noduli, granulomatous iridocyclitis, giant-cell sialadenitis, and arthralgia. The kidney biopsy revealed non-granulomatous interstitial nephritis. Treatment consisted of initial high-dose methylprednisolone pulse followed by oral prednisolone and methotrexate. Full remission was achieved. In addition, we performed a literature review using PubMed and analyzed data on pediatric renal sarcoidosis cases. Results: We identified 36 cases of pediatric sarcoidosis with renal involvement on presentation and data on the end-of-follow-up glomerular filtration rate (GFR). The data from the literature review showed that renal involvement was slightly more prevalent in males (60%). AKI was present in most of the described patients (84%). Oral prednisolone was used in 35 of 36 cases; in more severe cases, other immunosuppressants were used. We newly identified renal concentration impairment and granulomatous interstitial nephritis as factors with a clear trend toward GFR loss at the end of follow-up, emphasizing the importance of kidney biopsy in symptomatic patients. In contrast, higher GFR at presentation and hypercalcemia were rather favorable factors. According to the identified predictive factors, our patient has a good prognosis and is in remission. Conclusion: The factors indicating a trend toward an unfavorable renal outcome in pediatric sarcoidosis are renal concentration impairment and granulomatous interstitial nephritis at presentation, while a higher GFR is beneficial.
Antenna Theory Analysis And Design 3rd Edition Solution Manual

Modern Antenna HandbookPrinted AntennasAntenna Theory and ApplicationsThermodynamicsSolutions Manual to Accompany Antenna TheoryConformal Array Antenna Theory and DesignMicrostrip AntennasAntennas and Radar for Environmental Scientists and EngineersAntenna TheoryEngineering ElectromagneticsANTENNA THEORY AND DESIGN, REVISED EDAntenna Theory and DesignMicrostrip and Printed Antenna Design, 2nd EdnAntennasMicrostrip AntennaMicrostrip and Printed Antennas: Applications-Based DesignsAntenna Theory and Microstrip AntennasMicrowave Antenna Theory and DesignAntenna TheoryRectangular Dielectric Resonator AntennasAntenna Theory and DesignModern Antenna DesignMicrowave Engineering, 3Rd EdThe Handbook of Antenna DesignAntenna Theory & DesignAntenna TheoryAntenna TheoryAntenna HandbookIntroduction to Smart AntennasDesign and Applications of Active Integrated AntennasFoundations of Antenna Engineering: A Unified Approach for Line-of-Sight and MultipathThe Theory of Thin Antennas and Its Use in Antenna EngineeringAdvanced Engineering ElectromagneticsAntenna EngineeringANTENNA THEORY: ANALYSIS AND DESIGN, 2ND EDReflectarray AntennasPractical Antenna HandbookAntenna Analysis and Design Using FEKO Electromagnetic Simulation SoftwareAnalysis and Design of Transmitarray AntennasAdvanced Antenna Theory
Repetitive seizures after febrile period exclusively involving bilateral claustrum

Abstract The purpose of this study is to demonstrate the relationship between acute repetitive seizures and claustrum damage, and to provide basis for the treatment of repetitive seizures exclusively involved the bilateral claustrum. Between August 2014 and October 2015, 5 patients with repetitive seizures after a febrile period were admitted to our hospital, showing exclusive involvement of bilateral claustrum on magnetic resonance images (MRI). All patients underwent serum virology testing, autoimmune antibody test, MRI, and electroencephalograph examination. All patients were young women (16–29 years) with an unremarkable previous medical history, and 2 of them were pregnant. Similar clinical symptoms like antecedent febrile illness in the 3 to 7 days preceding seizures, psychiatric disorder, or dysautonomia occurred in 5 patients. Abnormal MRI signals exclusively confined to the bilateral claustrum appeared in 4 patients during the acute phase and in 1 patient during the chronic phase. All patients accepted empirical treatment with anti-viral and anti-seizure drugs and had good outcomes (seizure-free, though with some residual short-term memory loss) at the 3rd year follow-up. Although the clinical and associated brain imaging findings were characteristic, the etiology was still unclear. Contrary to previous studies, the patients presented here have all received a good prognosis.
Lupus podocytopathy superimposed on diabetic glomerulosclerosis

Abstract Rationale: Lupus podocytopathy (LP) is an entity that is increasingly being reported in the literature on systemic lupus erythematosus (SLE). LP is characterized by nephrotic syndrome in SLE patients with diffuse glomerular podocyte foot process effacement and no immune complex deposits along the capillary loops. Histologically, LP typically mimics minimal change disease or primary focal segmental glomerulosclerosis (FSGS) on a background of ISN/RPS class I or II lupus nephritis. In situations where there are coexistent glomerular diseases, however, LP may be easily masked by background lesions and overlapping clinical symptoms. Patient concerns: We report the case of a 24-year-old woman with type I diabetes, hypertension, psoriasis/rash, and intermittent arthritis who presented with abrupt onset of severe nephrotic proteinuria and renal insufficiency. Renal biopsy revealed nodular glomerulosclerosis and FSGS. Immune deposits were not identified by immunofluorescence or electron microscopy. Ultrastructurally, there was diffuse glomerular basement membrane thickening and over 90% podocyte foot process effacement. With no prior established diagnosis of SLE, the patient was initially diagnosed with diabetic nephropathy with coexistent FSGS, and the patient was started on angiotensin-converting enzyme inhibitors (ACEI) and diuretics. However, nephrotic proteinuria persisted and renal function deteriorated. The patient concurrently developed hemolytic anemia with pancytopenia. Diagnoses: Subsequent to the biopsy, serologic results showed positive autoantibodies against double strand DNA (dsDNA), Smith antigen, ribonucleoprotein (RNP), and Histone. A renal biopsy was repeated, revealing essentially similar findings to those of the previous biopsy. Integrating serology and clinical presentation, SLE was favored. The pathology findings were re-evaluated and considered to be most consistent with LP and coexistent diabetic nephropathy, with superimposed FSGS either as a component of LP or as a lesion secondary to diabetes or hypertension. Interventions: The patient was started on high-dose prednisone at 60 mg/day, with subsequent addition of mycophenolate mofetil and ACEI, while prednisone was gradually tapered. Outcomes: The patient's proteinuria, serum creatinine, complete blood counts, skin rash, and arthritis were all significantly improved. Conclusion: The diagnosis of LP when confounded by other glomerular diseases that may cause nephrotic syndrome can be challenging. Sufficient awareness of this condition is necessary for the appropriate diagnosis and treatment.
Hearing Outcomes with Percutaneous and Transcutaneous BAHA® Technology in Conductive and Mixed Hearing Loss

Objectives: To evaluate outcomes of BAHA Connect® and BAHA Attract® implantations, and to examine the prognostic utility of a preimplantation Softband®-attached processor trial. Study Design: Retrospective case review Setting: Tertiary referral center. Patients: Patients who underwent Connect® (19 ears) and Attract® (25 ears) implantation between 2007 and 2017. Intervention: BAHA® implantation. Main Outcome Measures: Unaided air conduction (AC), bone conduction (BC), and speech reception thresholds (SRTs), as well as free field (FF) aided with Softband®-attached processor and with implant-attached processor thresholds. Results: Serviceable implant-attached processor PTA0.5,1,2 kHz (≤35 dB HL) was achieved in 89 and 88% of the Connect® and the Attract® ears, respectively, while at 4 kHz this was achieved in 68 and 32% of the Connect® and the Attract® ears, respectively (p = 0.032). Significantly more Connect® ears showed alignment between FF aided with implant-attached processors thresholds and BC thresholds. The alignment between the Softband®-attached processors thresholds and implant-attached processors thresholds was similar in the two groups. Both groups exhibited similar positive improvement in the quality of life questionnaires Conclusions: Accessibility to sound with the implant-attached processor is well predicted by the pre-implantation Softband® trial, both in the BAHA Connect® and in the BAHA Attract® ears. Hearing rehabilitation targets at 0.5, 1, and 2 kHz are met by most Connect® and Attract® ears, while at 4 kHz the outcome with Attract® is poorer. This information should be presented to the patient during consultation prior to a decision as to the type of BAHA® device to be implanted.
Hsa_circ_0074491 regulates the malignance of cholesteatoma keratinocytes by modulating the PI3K/Akt pathway by binding to miR-22-3p and miR-125a-5p

Abstract Cholesteatoma is a benign cystic lesion that can continue to grow like a tumor. Circular ribonucleic acid (RNA) hsa_circ_0074491 (circ_0074491) has been reported to be down-regulated in cholesteatoma tissues. However, the role and regulatory mechanism of circ_0074491 in the growth of cholesteatoma are unclear. The expression of circ_0074491, microRNA (miR)-22-3p, and miR-125a-5p in cholesteatoma tissues was detected by quantitative real-time polymerase chain reaction. The proliferation, cell cycle, apoptosis, migration, and invasion of cholesteatoma keratinocytes were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, plate clone, flow cytometry, or transwell assays. Several protein levels were examined by western blotting. The targeting relationship between miR-22-3p or miR-125a-5p and circ_0074491 was verified via dual-luciferase reporter and RNA pull-down assays. We observed the downregulation of circ_0074491 in cholesteatoma tissues. Furthermore, circ_0074491 knockdown facilitated cell proliferation, migration, invasion, and repressed cell apoptosis in cholesteatoma keratinocytes. Circ_0074491 was verified as a decoy for miR-22-3p and miR-125a-5p in cholesteatoma keratinocytes. Both miR-22-3p and miR-125a-5p silencing reversed the impacts of circ_0074491 silencing on proliferation, apoptosis, migration, and invasion of cholesteatoma keratinocytes. Also, circ_0074491 knockdown activated the PI3K/Akt pathway in cholesteatoma keratinocytes via miR-22-3p and miR-125a-5p. Circ_0074491 played a suppressive role in cholesteatoma through inactivating the PI3K/Akt pathway via binding to miR-22-3p and miR-125a-5p, which provided a novel evidence for the involvement of circRNA in the development of cholesteatoma.
Prognostic value of red blood cell distribution width in predicting 3-month functional outcome of patients undergoing thrombolysis treatment for acute ischemic stroke

Abstract This study was performed to determine whether red blood cell distribution width (RDW) is associated with 3-month poor functional outcome in patients undergoing thrombolytic therapy for acute ischemic stroke. RDW was measured in patients with thrombolytic therapy in emergency department. Functional outcome was assessed after 3 months and poor functional outcome was defined as modified Rankin scale 3 to 6. A total of 240 patients were enrolled, and 82 (34.2%) had a poor functional outcome. The median RDW was significantly elevated in patients with a poor functional outcome compare with those with a good outcome. RDW was independently associated with a 3-month poor functional outcome (odds ratio 3.369, 95% confidence interval 2.214–5.125). The optimal RDW cutoff for predicting 3-month poor functional outcome was 12.8%, and the area under the curve for RDW was 0.818 (95% confidence interval 0.761–0.876). The area under the curve for RDW was higher in male patients than in female patients. The RDW correlated positively with the modified Rankin scale score after 3 months and the initial National Institutes of Health Stroke Scale score. Initial higher RDW level is related to a 3-month poor functional outcome in patients undergoing thrombolytic therapy for acute ischemic stroke.
BRAF V600E mutation and the Bethesda System for Reporting Thyroid Cytopathology of fine-needle aspiration biopsy for distinguishing benign from malignant thyroid nodules

Abstract Background: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) predicts the risk of malignancy for the different categories of the ultrasound-guided fine-needle aspiration biopsy (FNAB). The objective of this study is to investigate the efficiencies of the v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600E mutation test and the TBSRTC categories in distinguishing between benign and malignant thyroid nodules. Methods: In this study, 362 ultrasound-guided fine-needle aspiration (FNA) samples from 344 patients aged from 17 to 76 years old were retrospectively reviewed. The patients were classified into six groups (I–VI) according to the TBSRTC system. The amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was used to evaluate the BRAF V600E mutation level in total 362 samples. Among of the 344 patients, 128 patients (131 thyroid nodules) who underwent surgeries were followed by histopathological examination. The predictive values of the BRAF V600E mutation test and TBSRTC categories were evaluated in these 131 thyroid nodules. Results: The median ages of the patients in the TBSRTC IV–VI group were smaller than those in the TBSRTC I–III groups. The proportion of nodules over 1 cm was larger than it in the TBSRTC IV group compared to the other groups. Significant differences in BRAF V600E mutation were observed (P < .001) among these six groups. The sensitivity (89.57%) for the detection of malignant thyroid nodules, negative predictive value (NPV; 45.45%) for the detection of benign nodules, and accuracy (86.26%) for distinguishing between benign and malignant thyroid nodules increased by combining the BRAF V600E mutation test and TBSRTC system when compared with the BRAF V600E mutation test and TBSRTC system respectively. The BRAF V600E mutation test alone demonstrated the increased positive predictive value (PPV; 98.91%) and specificity (93.75%) for the detection of malignant thyroid nodules compared to the TBSRTC method (alone or in combination with the BRAF V600E method). Conclusion: In summary, significant differences in age, nodule diameter, and BRAF V600E mutation were noted among the six categories of the TBSRTC system. The combination of the BRAF V600E mutation test and TBSRTC system demonstrated increases in the NPV, sensitivity, and accuracy, while the BRAF V600E method proved superiority to the TBSRTC system with regard to the PPV and specificity.
Evaluating The Impact of ERP Systems on Value Added An applied study

The study aims to study and evaluate the relationship between the implementation of Enterprise Resources Planning (ERP) and value-added (VA) of firms. To achieve this aim, the literature related to the study had been reviewed, an applied study using data from financial statements and reports of El-Sewedy Electric Group of companies had been conducted. The findings of the study indicated that there is a statistically significant impact of the ERP systems on the annual interest, there is a statistically significant impact of the ERP systems on the annual profit, there is a statistically significant impact of the ERP systems on the annual taxes, there is a statistically significant impact of the ERP systems on the annual wages and salaries, there is a statistically significant correlation between ERP systems and VA of companies and there is a statistically significant impact of ERP systems on VA of companies. Key words: Value added (VA), Enterprise Resources of Planning (ERP) system.
Persuading the Implicit Mind: Changing Negative Implicit Evaluations With an 8-Minute Podcast

Implicit evaluations can be malleable via reinterpretation of previously encountered evidence. Here, we report three studies (N = 1,007) investigating the robustness of this updating modality using ecologically realistic materials. Participants were first introduced to a target who killed an endangered black rhino in Namibia. They then listened to a real podcast providing counterattitudinal information on the benefits of trophy hunting. The podcast resulted in considerable revisions of initially negative implicit evaluations toward positivity, consistently across implicit measures (affect misattribution procedures vs. implicit association test), samples (American students vs. nonstudents from various countries), study settings (lab vs. online), and the presence versus absence of a memory retrieval manipulation prompting reflection on participants’ views on trophy hunting. Taken together, these findings suggest that reinterpretation can shift implicit evaluations of even highly negative targets, including under conditions of external validity.
International Online Conference “One-Parameter Semigroups of Operators 2021” Extinction time of stochastic SIRS epidemic models: application of Chernoff approximation for bi-continuous semigroups

Introduction. The relationship between strongly continuous semigroups on Banach spaces and the solutions of initial value problems for partial differential equations is well established. However, very often we encounter PDEs whose corresponding semigroups are not strongly continuous. One way to treat such cases is by introducing a weaker topology to the underlying Banach space, for which to achieve that the corresponding semigroup is strongly continuous. Proposed by [4], the concept of bi-continuous semigroups describes such treatments in a general framework, with analogous generation theorems and approximation formulas. In the area of epidemiology and population genetics, the limits of many multi-dimensional discrete stochastic models turn out to be degenerate. In this work, we focus on a particular degenerate diffusion, occurring as the limit of stochastic epidemic SIRS models, when the population size tends to infinity. In solving the hitting time problem for this diffusion, we encounter the problem of a lack of strong continuity as described above, and subsequently prove that the corresponding degenerate operator generates a bi-continuous semigroup, using a generalised Chernoff product formula [3]. Since the corresponding second-order operator is associated with the squared Bessel process and the corresponding semigroup can be computed explicitly, we obtain an explicit Chernoff equivalent to the semigroup.
CHEMICAL COMPONENTS, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF GARLIC, CUMIN AND PARSLEY VOLATILE OILS

In this study, the chemical components of garlic, cumin and parsley volatile oils as well as the antioxidant and antimicrobial activities of these volatile oils and their mixtures were determined. Results indicated that garlic, parsley and cumin volatile oils contained eleven, thirteen and fourteen components which represented 96.47, 97.79 and 95.41%, respectively. Diallyl disulfide, diallyl trisulfide and allyl methyl trisulfide were the most abundant chemical compounds in garlic volatile oil, while myristicin was the major component of parsley volatile oil followed by α-pinene and γterpinene. However, cumin aldehyde, γ-terpinene, β-pinene and cuminic alcohol were the most predominant chemical compounds in cumin volatile oil. The highest antioxidant and antimicrobial activities were recorded for garlic and cumin volatile oils mixture (GC) followed by garlic and parsley volatile oils mixture (GP), while the lowest antioxidant and antimicrobial activities were found for parsley volatile oil. Finally, GC and GP volatile oils mixtures could be used in food industry as alternatives to synthetic antioxidants and antimicrobial substances. Key word: Chemical component, antioxidant, antimicrobial, volatile oils, cumin, garlic, parsley,
SOLOR IRRADIATION ANALYSIS USING PRESCRIPTIVE ANALYSIS

Solar Irradiation Analysis using Prescriptive Analysis is a design for an ideal solution, built on the user’s needs to analyze Solar Power Plants. It helps in delivering flawless operations on the data provided from the power plants, and predicts volatility in performance by providing probable reason of up-gradation/degradation in efficiency. It focuses on the idea of Sustainable Energy Resources as the future needs to be more Eco-friendly. Solar Irradiation Analysis using Prescriptive Analysis is the combination of hardware (which includes solar panels, invertors, connections, and other devices) and an Intuitive software (Coded in Python, using Data Analytics Techniques). Data Analytics which includes Descriptive Analysis, Predictive Analysis and Prescriptive Analysis is secure, reliable, and compatible with all kinds of data. The results are generated in the form of graphs and charts which can be useful in the long term for the future studies based on Solar Irradiation, and in the short term they provided better energy generation of Users. Keywords— Solar Irradiation, Ambient Temperature, Solar Data Analyzer
Pazopanib in rare histologies of metastatic soft tissue sarcoma

Background Uncommon histopathological subtypes account for less than 5% cases of soft tissue sarcoma (STS) and unclassified STSs comprise another 16%, these are often chemotherapy-resistant, with a dismal outcome in unresectable/metastatic disease. Prospective studies on the use of pazopanib in this cohort of patients are lacking in the literature. Here, we describe the safety and efficacy of pazopanib in rare histologies of advanced STS. Materials and methods We conducted a retrospective study at two tertiary cancer centres in India, evaluating 33 cases of rare subtypes of STS, who received pazopanib as per institutional protocol between January 2013 and December 2019. Patients who received pazopanib for unresectable/metastatic disease were enrolled in this study for clinicopathologic features, treatment outcome and evaluation of prognostic factors. Results Out of 33 patients, there were seven cases of undifferentiated pleomorphic sarcoma, four cases each of myxofibrosarcoma, epithelioid sarcoma and malignant peripheral nerve sheath tumour, three cases each of haemangiopericytoma and spindle cell sarcoma, two cases of haemangioendothelioma and a case each of clear cell sarcoma, retroperitoneal sarcoma, angiosarcoma and pleomorphic rhabdomyosarcoma-adult type. The objective response rate was 27%. Most of the patients (67%) received pazopanib in second or subsequent lines of therapy. The majority (70%) were started at a lower dose of 400/600 mg and only 43% of these (10/23) could be escalated to a full dose of 800 mg based on tolerance. On univariate analysis, pazopanib’s starting dose didn’t predict progression-free survival (PFS)/overall survival (OS)/response rate. At a median duration of follow-up of 18.8 months (range 1.9–150.4 months), the median PFS and median OS were 10.3 months (95% confidence interval (CI): 5.9–14.8) and 17.8 months (95% CI: 10.7–29.3), respectively. 27% of the patients experienced grade ¾ toxicities, 12% required dose modification of pazopanib and 21% needed permanent discontinuation due to toxicity. Conclusion Our study shows that pazopanib is active in rare subtypes of STS.