Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the uniformity of the excess gamma rays towards the galactic center region

We perform a composite likelihood analysis of subdivided regions within the central 26° × 20° of the Milky Way, with the aim of characterizing the spectrum of the gamma-ray galactic center excess in regions of varying galactocentric distance. Outside of the innermost few degrees, we find that the radial profile of the excess is background-model dependent and poorly constrained. The spectrum of the excess emission is observed to extend upwards of 10 GeV outside ∼5° in radius, but cuts off steeply between 10–20 GeV only in the innermost few degrees. If interpreted as a real feature of the excess, this radial variation in the spectrum has important implications for both astrophysical and dark matter interpretations of the galactic center excess. Single-component dark matter annihilation models face challenges in reproducing this variation; on the other hand, a population of unresolved millisecond pulsars contributing both prompt and secondary inverse Compton emission may be able to explain the spectrum as well as its spatial dependency. We show that the expected differences in the photon-count distributions of a smooth dark matter annihilation signal and an unresolved point source population are an order of magnitude smaller than the fluctuations in residuals after fitting the data, which implies that mismodeling is an important systematic effect in point source analyses aimed at resolving the gamma-ray excess.
The relationships between neuroglial alterations and neuronal changes in Alzheimer’s disease, and the related controversies I: Gliopathogenesis and glioprotection

Since Alois Alzheimer described the pathology of Alzheimer’s disease in 1907, an increasing number of studies have attempted to discover its causes and possible ways to treat it. For decades, research has focused on neuronal degeneration and the disruption to the neural circuits that occurs during disease progression, undervaluing in some extent the alterations to glial cells even though these alterations were described in the very first studies of this disease. In recent years, it has been recognized that different families of neuroglia are not merely support cells for neurons but rather key and active elements in the physiology and pathology of the nervous system. Alterations to different types of neuroglia (especially astroglia and microglia but also mature oligodendroglia and oligodendroglial progenitors) have been identified in the initial neuropathological changes that lead to dementia, suggesting that they may represent therapeutic targets to prevent neurodegeneration. In this review, based on our own studies and on the relevant scientific literature, we argue that a careful and in-depth study of glial cells will be fundamental to understanding the origin and progression of Alzheimer’s disease. In addition, we analyze the main issues regarding the neuroprotective and neurotoxic role of neuroglial changes, reactions and/or involutions in both humans with Alzheimer’s disease and in experimental models of this condition.
Treatment of Diaphyseal Fractures of the Femur in Paediatric Age Group: A Comparative Study of Locking Compression Plate Versus Titanium Elastic Nailing System (TENS)

Background: Diaphyseal femur fractures are commonly seen in the paediatric age group as there is an increase in the incidence of road traffic accidents. Titanium elastic nailing system (TENS) and plating are the common methods used for paediatric long bone fracture fixation. The purpose of our study was to evaluate and compare functional and radiological outcomes of paediatric femur diaphyseal fractures treated with locking compression plates and with TENS. Methods: Our study included 59 patients diagnosed with femur shaft fracture. Twenty-eight patients included in group one underwent open reduction and internal fixation with locking compression plates and 31 patients in group two underwent open reduction/closed reduction with intramedullary TENS. All post-operation patients were evaluated at four, eight, 10, 12, 16, 20, 24, and 36 weeks. The functional outcome was assessed based on the Flynn scoring system and radiological union based on fracture union on X-ray. Results: We analyzed our data using the Flynn scoring system. In group one, out of 28 cases treated with locking compression plates, 25 (89%) were excellent, two (7.5%) were satisfactory, and one (3.5%) was poor. In group two, out of 31 cases treated with intramedullary TENS, 26 (83.8%) were excellent and five (16.2%) were satisfactory. In our study, the average union time in group one was 11.4 weeks and in group two was 14.41 weeks. Fracture union was 100% in both groups. Conclusion: In our study, we noted that the union of the femur shaft was early with the use of locking compression plates. In TENS, there was less intraoperative blood loss, very minimal postoperative scar, and less soft tissue damage. Also, implant removal was easier compared to locking compression plates.
Effects of the tensor force on the ground state and first 2 + states of the magic Ca54 nucleus

The magic nature of the $^{54}$Ca nucleus is investigated in the light of the recent experimental results. We employ both HFB and HF+BCS methods using Skyrme-type SLy5, SLy5+T and T44 interactions. The evolution of the single-particle spectra is studied for the N=34 isotones: $^{60}$Fe, $^{58}$Cr, $^{56}$Ti and $^{54}$Ca. An increase is obtained in the neutron spin-orbit splittings of $p$ and $f$ states due to the effect of the tensor force which also makes $^{54}$Ca a magic nucleus candidate. QRPA calculations on top of HF+BCS are performed to investigate the first $J^{\pi}$=$2^{+}$ states of the calcium isotopic chain. A good agreement for excitation energies is obtained when we include the tensor force in the mean-field part of the calculations. The first $2^{+}$ states indicate a subshell closure for both $^{52}$Ca and $^{54}$Ca nuclei. We confirm that the tensor part of the interaction is quite essential in explaining the neutron subshell closure in $^{52}$Ca and $^{54}$Ca nuclei.
Radial-orbit instability in modified Newtonian dynamics

The stability of radially anisotropic spherical stellar systems in modified Newtonian dynamics (MOND) is explored by means of numerical simulations performed with the N-body code n-mody. We find that Osipkov–Merritt MOND models require for stability larger minimum anisotropy radii than equivalent Newtonian systems (ENSs) with the dark matter, and also than purely baryonic Newtonian models with the same density profile. The maximum value for stability of the Fridman–Polyachenko–Shukhman parameter in MOND models is lower than in ENSs, but higher than in Newtonian models with no dark matter. We conclude that MOND systems are substantially more prone to radial-orbit instability than ENSs with dark matter, while they are able to support a larger amount of kinetic energy stored in radial orbits than purely baryonic Newtonian systems. An explanation of these results is attempted and their relevance to the MOND interpretation of the observed kinematics of globular clusters, dwarf spheroidal and elliptical galaxies is briefly discussed.
K i d n e y D i s e a s e a n d S a r s - c o V- 2 I n f e c t i o n Challenges and Considerations for Nursing

which was one of the earliest studies evaluating the humoral response of individuals receiving dialysis after vaccination with the Bio-NTech 162b2 mRNA vaccine. Individuals receiving dialysis (n 5 22) were compared with healthy individuals without CKD (n 5 46). Antibody levels were measured before enrollment and following vaccinations. Antigen rapid tests for sars-coV-2 infection were performed before each dialysis treatment. Individuals that contracted the disease were excluded. IgG levels were also monitored. Due to the difference in age among the dialysis and control groups, a subanalysis was performed. Speers and colleagues (2021) identified that individuals on dialysis developed significantly less sars-coV-2 anti-S1 IgG antibodies following the first and second COVID-19 vaccination compared with the age-matched healthy individuals. The results obtained by Speers and colleagues (2021) were consistent with prior studies examining the immune response of individuals receiving the influenza A and Hepatitis B vaccines in the presence of kidney disease. Individuals receiving dialysis are a high-risk group for sars-coV-2 infection. The findings by Speer and colleagues (2021) indicate that the first COVID-19 vaccination dose may not provide adequate coverage. Additional research is needed to evaluate the response and effectiveness of vaccinations for individuals receiving dialysis.
Towards equation of state of dark energy from quasar monitoring: Reverberation strategy

Context. High-redshift quasars can be used to constrain the equation of state of dark energy. They can serve as a complementary tool to supernovae Type Ia, especially at z > 1. Aims. The method is based on the determination of the size of the broad line region (BLR) from the emission line delay, the determination of the absolute monochromatic luminosity either from the observed statistical relation or from a model of the formation of the BLR, and the determination of the observed monochromatic flux from photometry. This allows the luminosity distance to a quasar to be obtained, independently from its redshift. The accuracy of the measurements is, however, a key issue. Methods. We modeled the expected accuracy of the measurements by creating artificial quasar monochromatic lightcurves and responses from the BLR under various assumptions about the variability of a quasar, BLR extension, distribution of the measurements in time, accuracy of the measurements, and the intrinsic line variability. Results. We show that the five-year monitoring of a single quasar based on the Mg II line should give an accuracy of 0.06−0.32 mag in the distance modulus which will allow new constraints to be put on the expansion rate of the Universe at high redshifts. Successful monitoring of higher redshift quasars based on C IV lines requires proper selection of the objects to avoid sources with much higher levels of the intrinsic variability of C IV compared to Mg II.
On the existence of embedded minimal 2-spheres in the 3-sphere, endowed with an arbitrary metric

First, by modifying the minimax techniques of Pitts [2] , i t is shown that there exists in N a stationary 2-varifold V which can be written as the (varifold) limit of embedded 2-spheres and which has certain local stability properties. Then, using these stability properties together with the recently developed regularity theorems of Almgren and Simon [/] and Schoen, Simon and Yau [4], one can prove that V has the form
Reanalysis of Rosenbluth measurements of the proton form factors

We present a reanalysis of the data from Stanford Linear Accelerator Center (SLAC) experiments E140 [R. C. Walker et al., Phys. Rev. D 49, 5671 (1994)] and NE11 [L. Andivahis et al., Phys. Rev. D 50, 5491 (1994)] on elastic electron-proton scattering. This work is motivated by recent progress in calculating the corresponding radiative corrections and by the apparent discrepancy between the Rosenbluth and polarization transfer measurements of the proton electromagnetic form factors. New, corrected values for the scattering cross sections are presented, as well as a new form factor fit in the ${Q}^{2}$ range from 1 to 8.83 ${\text{GeV}}^{2}$. We also provide a complete set of revised formulas to account for radiative corrections in single-arm measurements of unpolarized elastic electron-proton scattering.
Interplay between local quantum randomness and non-local information access

Quantum randomness is considered to be potentially an important resource for information processing. Quantum randomness stems from quantum coherence, whose information-theoretic characterization is currently under investigation. In this work, we link the quantum randomness of a measurement with a particular notion of coherence. We show that the quantum randomness of a local measurement corresponds to the minimum amount of uncertainty about the outcome experienced by a correlated party. The relation between local quantum randomness and quantum correlations is discussed. We observe that the local quantum randomness on one party corresponds to the bits to be sent to a correlated receiver to unlock hidden data.
Implications of magnetar non‐precession

The objects known as anomalous X-ray pulsars and soft gamma repeaters are commonly identified with magnetars, neutron stars with ultrastrong magnetic fields. The rotational history of these objects has, so far, revealed no evidence of free precession. At the same time these objects do not generally appear to have magnetic axes nearly parallel or orthogonal to their spin axes. In this paper we show that the combination of these two observations, together with simple rigid-body dynamics, leads to non-trivial predictions about the interior properties of magnetars: either (i) elastic stresses in magnetar crusts are close to the theoretical upper limit above which the crustal matter yields or (ii) there is a "pinned" superfluid component in the magnetar interior. As a potentially observable consequence of these ideas we point out that, in the case of no pinned superfluidity, magnetars of stronger magnetic field strength than those currently observed would have to be nearly aligned/orthogonal rotators.
Risk factors for suicide following treatment with electroconvulsive therapy: A nationwide study of 11,780 patients

Objectives: Despite the well-established anti-suicidal effect of electroconvulsive therapy (ECT), patients receiving ECT remain at high risk of dying from suicide. In the present study, we aimed to quantify this risk and identify risk factors for suicide among patients receiving ECT. Methods: We used nationwide Danish registers to identify all patients that initiated ECT between 2006 and 2016. These patients were matched on sex and age to 10 reference individuals from the general Danish population. First, we compared 2-year suicide risk between patients initiating ECT and the matched reference individuals. Second, we investigated if any patient characteristics were associated with suicide following ECT via Cox proportional-hazards regression. Results: A total of 11,780 patients receiving ECT and 117,800 reference individuals were included in the analyses. Among the patients receiving ECT, 161 (1.4%) died from suicide within two years. Compared to the reference individuals, patients receiving ECT had a substantially elevated suicide rate (Hazard rate ratio (HRR)=44.5, 95%CI=31.1-63.6). Among those receiving ECT, we identified the following risk factors for suicide: Male sex (HRR=2.3, 95%CI=1.7-3.1), age 60-70 years (HRR=1.6, 95%CI=1.0-2.6), Medium-term higher education (HRR=1.5, 95%CI=1.0-2.2); Long-term higher education (HRR=1.9, 95%CI=1.1-3.1), history of substance use disorder (HRR=2.0, 95%CI=1.4-2.8) and history of intentional self-harm/suicide attempt (HRR=4.0, 95%CI=2.8-5.8). Conclusion: Among patients receiving ECT, those who are male, aged 60-70 years, have medium-term to long-term higher education, or have a history of substance use disorder or intentional self-harm/suicide attempt, are at particularly elevated risk of suicide. These findings may guide initiatives to reduce the risk of suicide.
Relative volume as a doubly stochastic binomial point process

Relative intra-day cumulative volume is intra-day cumulative volume divided by final total volume. If intra-day cumulative volume is modeled as a Cox (doubly stochastic Poisson) point process, then using initial enlargement of filtration with the filtration of the Cox process enlarged by knowledge of final volume, it is shown that relative intra-day volume conditionally has a binomial distribution and is a novel generalization of a binomial point process: the doubly stochastic binomial point process. Re-scaling the intra-day traded volume to a relative volume between 0 (no volume traded) and 1 (daily trading completed) allows empirical intra-day volume distribution information for all stocks to be used collectively to estimate and identify the random intensity component of the doubly stochastic binomial point process and closely related Cox point process.
Radiation from a D-dimensional collision of shock waves: higher order set up and perturbation theory validity

The collision of two D-dimensional, ultra-relativistic particles, described in General Relativity as Aichelberg-Sexl shock waves, is inelastic. In first order perturbation theory, the fraction of the initial centre of mass energy radiated away was recently shown to be 1/2 - 1/D. Here, we extend the formalism to higher orders in perturbation theory, and derive a general expression to extract the inelasticity, valid non-perturbatively, based on the Bondi mass loss formula. Then, to clarify why perturbation theory captures relevant physics of a strong field process in this problem, we provide one variation of the problem where the perturbative framework breaks down: the collision of ultra-relativistic charged particles. The addition of charge, and the associated repulsive nature of the source, originates an extra radiation burst, which we argue to be an artifact of the perturbative framework, veiling the relevant physics.
Illuminating the dark metabolome of Pseudo-nitzschia-microbiome associations.

The exchange of metabolites mediates algal and bacterial interactions that maintain ecosystem function. Yet, while 1000s of metabolites are produced, only a few molecules have been identified in these associations. Using the ubiquitous microalgae Pseudo-nitzschia sp. , as a model, we employed an untargeted metabolomics strategy to assign structural characteristics to the metabolites that distinguished specific diatom-microbiome associations. We cultured five species of Pseudo-nitzschia, including two species that produced the toxin domoic acid, and examined their microbiomes and metabolomes. A total of 4826 molecular features were detected by tandem mass spectrometry. Only 229 of these could be annotated using available mass spectral libraries, but by applying new in-silico annotation tools, characterization was expanded to 2710 features. The metabolomes of the Pseudo-nitzschia-microbiome associations were distinct and distinguished by structurally diverse nitrogen compounds, ranging from simple amines and amides to cyclic compounds such as imidazoles, pyrrolidines, and lactams. By illuminating the dark metabolomes, this study expands our capacity to discover new chemical targets that facilitate microbial partnerships and uncovers the chemical diversity that underpins algae-bacteria interactions. This article is protected by copyright. All rights reserved.
The developing juvenile distal tibia: Radiographic identification of distinct ontogenetic phases and structural trajectories

A novel combination of radiographic colour gradient mapping and radiographic absorptiometry was utilised to examine 96 human distal tibiae from 54 individuals ranging in age‐at‐death from the foetal to 23 years. The purpose of this was to identify previously undocumented changes in the internal organisation during the development of the distal tibia and determine whether these changes could be described as distinct phases. Previous studies have demonstrated a rudimentary structural organisation in other skeletal elements that mirror more mature patterns of bone organisation. Results showed that the perinatal tibia did not exhibit a rudimentary structural pattern similar to the architecture observed within the late adolescent tibia. This lack of early internal organisation is hypothesised to be related to the rudimentary ossification process that is being laid down around a pre‐existing vascular template which will be subsequently modified by locomotive forces. Between birth and 2 years of age, the tibia exhibited a period of regression where radiodensity decreased in comparison to the perinatal tibia. This period of regression was postulated to be due to a combination of factors including changing locomotive forces, weaning and growth resulting in a stage of development which is extremely demanding on calcium liberation from the skeleton. After 2 years of age, the distal tibia demonstrated refinement where radiographic trajectories progressively developed into patterns consistent with adult trabecular organisation. These trajectories are linked to the forces associated with the bipedal gait, suggesting a strong influence of biomechanical forces on the development of the distal tibia.
Effect of dopant atoms on local superexchange in cuprate superconductors: A perturbative treatment

Recent scanning tunneling spectroscopy experiments have provided evidence that dopant impurities in high- Tc superconductors can strongly modify the electronic structure of the CuO2 planes nearby, and possibly influence the pairing. To investigate this connection, we calculate the local magnetic superexchange J between Cu ions in the presence of dopants within the framework of the three-band Hubbard model, up to fifth-order in perturbation theory. We demonstrate that the sign of the change in J depends on the relative dopant-induced spatial variation of the atomic levels in the CuO2 plane, contrary to results obtained within the one-band Hubbard model. We discuss some realistic cases and their relevance for theories of the pairing mechanism in the cuprates
Practices and opinions of New Zealand sheep farmers towards pain management in lambs during castration and/or tail docking

ABSTRACT Aims To collect baseline data from New Zealand sheep farmers on techniques for docking and castrating lambs, their perceptions of the level of pain lambs experience following these procedures, and their opinions about the use of pain relief. Methods From a voluntary cross-sectional survey of New Zealand sheep farmers, descriptive statistics were provided for quantitative study variables. Thematic analysis was performed on the free-text comments. Univariable logistic regression was used to assess factors associated with farmers indicating they would consider using a device allowing administration of pain relief simultaneously with castration and tail docking. Results There were 432 survey responses containing sufficiently complete data for analysis. Of the 340 individuals (77.5%) always or sometimes performing castration of ram lambs, 242 (72.2%) used rubber rings for complete castration, 23 (6.9%) used the short scrotum method for cryptorchid castration, and 75 (22.4%) used a combination of both methods. Of the 423 individuals (97.9%) who indicated that they always or sometimes performed tail docking, 245 (57.9%) used a hot iron only, 148 (35.0%) used a rubber ring only, 26 (5.8%) used both methods, 3 (0.7%) used a surgical knife, and 1 (0.2%) provided no response. Less than 2% of respondents always or sometimes used pain relief for these procedures. Of the 432 respondents, 139 (32.2%) and 180 (41.7%) strongly agreed that castration and tail docking do not cause sufficient pain to warrant using pain relief, respectively. Time and cost were identified as major barriers to providing pain relief. In the unadjusted logistic regression analyses, respondents who were female, had high levels of education, had been farming < 20 years, who believed lambs experienced high levels of pain following the procedures, and who believed pain lasted longer than 6 hours, were more likely to indicate willingness to use pain control devices. Conclusion and clinical relevance Our results suggest very few New Zealand sheep farmers currently provide lambs with pain relief following tail docking or castration. This is likely due to the perception that the procedures are not painful enough to warrant pain relief, and concern over time and cost. This highlights the need to educate farmers about lamb pain and distress following tail docking and castration, and its negative impact on animal welfare. Farmers also need pain relief techniques and tools that can be administered simultaneously with these procedures to save time and labour cost.