Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased Expression of Cyclooxygenase-2 and Increased Infiltration of Regulatory T Cells in Tumors of Patients with Hepatocellular Carcinoma

Background: Studies on Cox-2 and Foxp3+ regulatory T cells (Treg) in hepatocellular carcinoma (HCC) showed that Treg suppress local immune response in a Cox-2-dependent fashion. Aims: To investigate Cox-2 expression, Foxp3+ Treg infiltration and CD4+ T cell frequency in HCC tumors. Methods: Tumors and the corresponding nontumor hepatitis B virus-related liver tissues from 40 HCC patients with hepatitis B virus infection, plus 10 liver samples from patients with hemangioma as controls, were assessed for Cox-2 expression, Foxp3+ Treg and total CD4+ T cell numbers using immunohistochemistry. Serum TGF-β1 was assessed by ELISA. Results: Reduced Cox-2 expression, increased Treg and increased CD4+ T cells were shown in tumor as compared with nontumor tissues. Moreover, of 40 tumor tissues, 23 that expressed Cox-2 showed increased Foxp3+ Treg and reduced CD4+ T cells compared with the remaining 17 that did not express Cox-2. Correlation analyses showed that within tumors Treg infiltration correlated positively with Cox-2 expression, and that Treg infiltration or Cox-2 expression correlated negatively with CD4+ T cells. Additionally, serum TGF-β1 was higher in HCC patients than in controls. Conclusion: Within tumors, Cox-2 expression, Treg infiltration and CD4+ T cell frequency were increased, and the Cox-2 expression correlated positively with Treg infiltration and negatively with CD4+ T cell frequency.
Social acceptance of genetic engineering technology

Genetic engineering of animals has been proposed to address societal problems, but public acceptance of the use of this technology is unclear. Previous work has shown that the source of information proposing the technology (e.g. companies, universities), the term used to describe the technology (e.g. genome editing, genetic modification), and the genetic engineering application (e.g. different food products) affects technology acceptance. We conducted three mixed-method surveys and used a causal trust-acceptability model to understand social acceptance of genetic engineering (GE) by investigating 1) the source of information proposing the technology, 2) the term used to describe the technology, and 3) the GE application for farm animals proposed. Further, participants expressed their understanding of technology using a range of terms interchangeably, all describing technology used to change an organism’s DNA. We used structural equation modelling and confirmed model fit for each survey. In each survey, perceptions of benefit had the greatest effect on acceptance. Following our hypothesized model, social trust had an indirect influence on acceptance through similar effects of perceived benefit and perceived risk. Additional quantitative analysis showed that the source of information and technology term had little to no effect on acceptance. Applications involving animals were perceived as less beneficial than a plant application, and an application for increased cattle muscle growth was perceived as more risky than a plant application. When assessing the acceptability of applications participants considered impacts on plants, animals, and people, trust in actors and technologies, and weighed benefits and drawbacks of GE. Future work should consider how to best measure acceptability of GE for animals, consider contextual factors and consider the use of inductive frameworks.
lymphoblastic leukemia ( ALL ) : analysis of cytogenetic data from Karyotype is an independent prognostic factor in adult acute

M. Rowe, Anthony H. Goldstone and Gordon W. Dewald Fielding, Letizia Foroni, Elisabeth Paietta, Martin S. Tallman, Mark R. Litzow, Peter H. Wiernik, Jacob Secker-Walker, Mary Martineau, Gail H. Vance, Athena M. Cherry, Rodney R. Higgins, Adele K. Anthony V. Moorman, Christine J. Harrison, Georgina A. N. Buck, Sue M. Richards, Lorna M. UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial patients treated on the Medical Research Council (MRC) lymphoblastic leukemia (ALL): analysis of cytogenetic data from Karyotype is an independent prognostic factor in adult acute
P771: PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA AND CLINICALLY SIGNIFICANT EXTRAVASCULAR HEMOLYSIS ON RAVULIZUMAB/ECULIZUMAB SHOWED HEMOGLOBIN RESPONSE SUPERIORITY WITH ADD-ON DANICOPAN VS PLACEBO

Book Citations: Authors, Title, HemaSphere, 2023;7(S3):pages. The individual abstract DOIs can be found at https://journals.lww. com/hemasphere/pages/default.aspx. Disclaimer: Articles published in the journal HemaSphere exclusively reflect the opinions of the authors. The authors are responsible for all content in their abstracts including accuracy of the facts, statements, citing resources, etc. 1424 Rav/Ecu (Table). Effective control of lactate dehydrogenase was maintained with danicopan or placebo plus Rav/Ecu. The safety analysis set comprised 49 and 24 pts in the danicopan and placebo arms, respectively. Mean (SD) study drug compliance was 98.8% (3.74); 11/49 (22.4%) pts were escalated to 200 mg TID. Overall, 71.4% (n=35 pts; 106 events) and 62.5% (n=15 pts; 65 events) of pts had ≥1 TEAE in the danicopan and placebo arms, respectively; no TEAEs were grade 4 or 5 in severity. TEAEs of liver enzyme elevations were reported in 12.2% of pts in the danicopan arm and 8.3% of pts in the placebo arm; none were considered serious. One pt in each arm discontinued treatment due to liver enzyme elevations. Serious AEs were reported by 2 pts in each arm (danicopan: cholecystitis, COVID-19; placebo: anemia, abdominal pain); none were considered related to study drug. There were no deaths, meningococcal infections, or discontinuations due to hemolysis.
Speakers of different languages remember visual scenes differently

Language can have a powerful effect on how people experience events. Here, we examine how the languages people speak guide attention and influence what they remember from a visual scene. When hearing a word, listeners activate other similar-sounding words before settling on the correct target. We tested whether this linguistic coactivation during a visual search task changes memory for objects. Bilinguals and monolinguals remembered English competitor words that overlapped phonologically with a spoken English target better than control objects without name overlap. High Spanish proficiency also enhanced memory for Spanish competitors that overlapped across languages. We conclude that linguistic diversity partly accounts for differences in higher cognitive functions such as memory, with multilinguals providing a fertile ground for studying the interaction between language and cognition.
Holistic Resource Management

A companion to Holistic Resource Management, the Holistic Resource Management Workbook provides the practical instruction in financial, biological, and land planning necessary to apply the holistic management model. Allan Savory's teaching approach was developed and tested in classes for ranchers, farmers, and government agency personnel. Case studies drawn from real-life situations and presented in clear language lead the reader through the planning process.
Air-Sea and Lateral Exchange Processes in East Indian Coastal Current off Sri Lanka

Abstract : The long-term goal of our research program is to understand sub-seasonal processes, from small-scale mixing to the reversal of monsoonal currents, in the Bay of Bengal (BoB) and around Sri Lanka and the role of regional air-sea interactions in their dynamics. The research is conducted in the context of the ASIRI-EBOB ONR DRI, and in conjunction with the ongoing ASIRI-RAWI project, which is funded under the Northern Arabian Sea circulation autonomously researched (NAScar) DRI. The PIs seek long term collaboration with Indian Ocean countries (IO), through partnerships and capacity building.
The interaction between macroprudential and monetary policies: The cases of Norway and Sweden

To shed light on the interaction between macroprudential and monetary policies, we study the inward transmission of foreign monetary policy in conjunction with domestic macroprudential and monetary policies in Norway and Sweden. Using detailed bank-level data we show how Norwegian and Swedish banks' lending reacts to monetary policy surprises arising abroad, controlling for the domestic macroprudential stance and the interaction between monetary and macroprudential policies. In both countries, the domestic macroprudential policy helps mitigate the effects arising after foreign monetary surprises.
Venous Thromboembolism in Cancer Patients: Comparison of Lung Cancer Patients to Other Solid Tumor Patients in a Prospective Observational Study

Background: Lung cancer (LC) is the most frequent solid tumor diagnosed worldwide and is one of the most common tumors in series of patients with cancer-related venous thromboembolism (VTE). The aim of this study was to analyze the clinical characteristics and outcome of VTE in patients with LC compared to patients with other types of cancer (OC). Patients and Methods: A prospective observational study enrolling consecutive cancer patients with newly diagnosed VTE was performed from May 2006 to April 2009 in our Department of Medical Oncology. All patients were uniformly treated and followed according to the American College of Chest Physicians guidelines. Advances in Cancer: Research & Treatment 2 Results: A total of 340 cancer patients were enrolled with LC being the most frequent primary tumor in 89 (26%) patients (69 male; mean age 62 ± 11 years). VTE was diagnosed earlier in patients with LC after the initial cancer diagnosis, with a median of 4 months (95% CI 2.795.20) compared to 7 months (95% CI 4.40-9.59) in patients with OC (p<0.0001). The VTE presented as pulmonary embolism in a higher proportion of patients with LC (51% vs 28%, p=0.005) although there were no differences in VTE-related outcomes due to the acute thrombotic event. After a mean follow-up of 14 ± 13 months no significant differences were found in venous re-thrombosis, major-bleeding or causes of death in patients with LC and OC. Conclusion: VTE in patients with LC occurs earlier after cancer diagnosis although no differences in VTE-related outcomes were observed compared to patients with OC.
Fluorine chemistry at extreme conditions: possible synthesis of $HgF_4$

By irradiating a pressurized mixture of a fluorine-bearing compound ($XeF_2$) and $HgF_2$ with synchrotron hard x-rays (>7 keV) inside a diamond anvil cell, we have observed dramatic changes in the far-infrared spectrum within the 30-35 GPa pressure range which suggest that we may have formed $HgF_4$ in the following way: $XeF_2 \xrightarrow{hv} Xe + F_2$ (photochemically) and $HgF_2 + F_2 \rightarrow HgF_4$ (30 GPa < P < 35 GPa). This lends credence to recent theoretical calculations by Botana et al. that suggest that Hg may behave as a transition metal at high pressure in an environment with an excess of molecular fluorine. The spectral changes were observed to be reversible during pressure cycling above and below the above mentioned pressure range until a certain point when we suspect that molecular fluorine diffused out of the sample at lower pressure. Upon pressure release, $HgF_2$ and trace $XeF_2$ were observed to be remaining in the sample chamber suggesting that much of the $Xe$ and $F_2$ diffused and leaked out from the sample chamber. Received: 29 October 2018, Accepted: 18 January 2019; Edited by: A. Goñi, A. Cantarero, J. S. Reparaz; DOI: http://dx.doi. org/10.4279/PIP.110001 Cite as: M Pravica, S Schyck, B Harris, P Cifligu, E Kim, B Billinghurst, Papers in Physics 11, 110001 (2019). This paper, by M Pravica, S Schyck, B Harris, P Cifligu, E Kim, B Billinghurst, is licensed under the Creative Commons Attribution License 4.0.
High-Throughput CSF Proteomics and Machine Learning to Identify Proteomic Signatures for Parkinson Disease Development and Progression

Background and Objectives This study aimed to identify CSF proteomic signatures characteristic of Parkinson disease (PD) and evaluate their clinical utility. Methods This observational study used data from the Parkinson's Progression Markers Initiative (PPMI), which enrolled patients with PD, healthy controls (HCs), and non-PD participants carrying GBA1, LRRK2, and/or SNCA pathogenic variants (genetic prodromals) at international sites. Study participants were chosen from PPMI enrollees based on the availability of aptamer-based CSF proteomic data, quantifying 4,071 proteins, and classified as patients with PD without GBA1, LRRK2, and/or SNCA pathogenic variants (nongenetic PD), HCs, patients with PD carrying the aforementioned pathogenic variants (genetic PD), or genetic prodromals. Differentially expressed protein (DEP) analysis and the least absolute shrinkage and selection operator (LASSO) were applied to the data from nongenetic PD and HCs. Signatures characteristics of nongenetic PD were quantified as a PD proteomic score (PD-ProS), validated internally and then externally using data of 1,556 CSF proteins from the LRRK2 Cohort Consortium (LCC). We further tested the PD-ProS in genetic PD and genetic prodromals and examined associations with clinical progression. Results Data from 279 patients with nongenetic PD (mean ± SD, age 62.0 ± 9.6 years; male 67.7%) and 141 HCs (age 60.5 ± 11.9 years; male 64.5%) were used for PD-ProS derivation. From 23 DEPs, LASSO determined weights of 14 DEPs for the PD-ProS (area under the curve [AUC] 0.83, 95% CI 0.78–0.87), validated in an independent internal validation cohort of 71 patients with nongenetic PD and 35 HCs (AUC 0.81, 95% CI 0.73–0.90). In the LCC, only 5 of the 14 DEPs were also measured. Notably, these 5 DEPs still distinguished 34 patients with nongenetic PD from 31 HCs with the same weights (AUC 0.75, 95% CI 0.63–0.87). Furthermore, the PD-ProS distinguished 258 patients with genetic PD from 365 genetic prodromals. Finally, regardless of genetic status, the PD-ProS independently predicted both cognitive and motor decline in PD (dementia, adjusted hazard ratio in the highest quintile [aHR-Q5] 2.8 [95% CI 1.6–5.0]; Hoehn and Yahr stage IV, aHR-Q5 2.1 [95% CI 1.1–4.0]). Discussion By integrating high-throughput proteomics with machine learning, we identified PD-associated CSF proteomic signatures crucial for PD development and progression. Trial Registration Information ClinicalTrials.gov (NCT01176565). A link to the trial registry page is clinicaltrials.gov/ct2/show/NCT01141023. Classification of Evidence This study provides Class II evidence that the CSF proteome contains clinically important information regarding the development and progression of Parkinson disease that can be deciphered by a combination of high-throughput proteomics and machine learning.
Auto‐adjusted versus fixed positive airway pressure in patients with severe OSA: A large randomized controlled trial

Continuous positive airway pressure (CPAP) in the treatment of severe obstructive sleep apnoea (OSA) can be used in fixed CPAP or auto‐adjusted (APAP) mode. The aim of this prospective randomized controlled clinical study was to evaluate the 3 month‐efficacy of CPAP used either in fixed CPAP or APAP mode.
OBSERVATIONS OF ICE FLOE STRESS IN THE EASTERN ARCTIC

During the early 1988, three fluid-filled, 20cm diameter uniaxial stress sensors were implanted in a rosette pattern in a multi-year ice floe in the Eastern Arctic. The implantation site was selected by surveying the ice surface and depth to locate a region of near constant ice thickness. On-site laboratory tests were conducted to measure the bending strength and young's modulus of lead ice and compressive strength and Young's modulus of multi-year ice. A pressure ridge was formed from the lead ice at the edge of a multi-year ice. A pressure ridge was formed from the lead ice at the edge of a multi-year floe in which the stress sensors were implanted. In this paper ridging forces are derived from the stress sensor data and compared against predicted force levels from several models. Observations of ridge sail height are compared with the limit heights of a ridge calculated from ridge building models. Stress data indicate that the forces occurring prior to ridge building may be larger than those forces which occurred during the ridging event.
Nearctic Dactylogyrus species (Platyhelminthes, Monogenea) parasitizing cypriniform fishes in the context of morphology and phylogeny, with descriptions of seven new species

Ribosomal DNA sequences are currently available for 32 morphologically recognized species of Dactylogyrus parasitizing Nearctic cypriniforms, but only 16 of them are assigned to nominal species. Herein, morphological data on 28 of the 32 species are provided, together with comments on their phylogenetic relationships in the context of the morphology of taxonomically important structures. Seven new species of Dactylogyrus are described from five species of leuciscids and one species of catostomids, as follows: D. aduncus n. sp. from Campostoma spadiceum, D. cloutmani n. sp. from Luxilus chrysocephalus isolepis, D. cornifrons n. sp. from Cyprinella venusta, D. fimbratus n. sp. from Rhinichthys cataractae, D. mcallisteri n. sp. from Semotilus atromaculatus, and D. chieni n. sp. and D. haneki n. sp. from Hypentelium nigricans. Four previously described species of Dactylogyrus, D. atromaculatus from S. atromaculatus, D. eos from C. neogaeus, D. parvicirrus from Notemigonus crysoleucas and D. perlus from L. c. isolepis, are redescribed and/or figured. As for the remaining 17 species, only the male copulatory organs (MCOs) taken from the respective hologenophores are illustrated. On the basis of phylogenetic analyses, two main clades of Nearctic Dactylogyrus were recognized and supported by the different morphology of the MCO. The first one included 22 strictly Nearctic species sharing the same MCO type with Dactylogyrus spp. parasitizing cyprinids likely of Asian origin. The second clade encompassed Dactylogyrus spp. with diverse MCO morphology and was placed in the sister position to Dactylogyrus spp. parasitizing European leuciscids and North-West African cyprinids.
Unravelling marker trait associations linking nutritional value with pigmentation in rice seed

While considerable breeding effort has focused on increasing the yields of staple crops such as rice and the levels of micronutrients such as iron and zinc, breeding to address the problems of the double‐burden of malnutrition has received less attention. Pigmented rice has higher nutritional value and greater health benefits compared to white rice. However, the genetic associations underlying pericarp coloration and accumulation of nutritionally valuable compounds is still poorly understood. Here we report the targeted genetic analysis of 364 rice accessions, assessing the genetic relationship between pericarp coloration (measured using multi‐spectral imaging) and a range of phenolic compounds with potential nutritional and health‐promoting characteristics. A genome‐wide association study resulted in the identification of over 280 single nucleotide polymorphisms (SNPs) associated with the traits of interest. Many of the SNPs were associated with more than one trait, colocalization occurring between nutritional traits, and nutritional and color‐related traits. Targeted association analysis identified 67 SNPs, located within 52 candidate genes and associated with 24 traits. Six haplotypes identified within the genes Rc/bHLH17 and OsIPT5 indicated that these genes have an important role in the regulation of a wide range of phenolic compounds, and not only those directly conferring pericarp color. These identified genetic linkages between nutritionally valuable phenolic compounds and pericarp color present not only a valuable resource for the enhancement of the nutritional value of rice but an easy method of selection of suitable genotypes.
Assessing vaccine effectiveness for varicella in Wuxi, China: a time-series analysis

Abstract Objective The varicella vaccine is not included in the national childhood immunization schedules in China. Varicella epidemics and outbreaks are frequently reported, and the evidence for the effectiveness of the varicella vaccine remains unclear. The aim of this study was to investigate varicella vaccine effectiveness in Wuxi, China. Methods Varicella surveillance data were extracted from the China Information System for Disease Control and Prevention, and vaccination data were obtained from the Vaccination Integrated Service Management Information System of Jiangsu Province, China. Time-series analysis approaches were used to estimate varicella vaccine effectiveness. Results A total of 16,093 varicella cases among children aged 1–6 years between January 2016 and December 2020 were analysed. A total of 217,297 children completed a two-dose varicella vaccination series. Compared with districts with lower vaccination rates, districts in Wuxi with higher varicella vaccination rates had a lower proportion of cases (p < 0.001). In the time-series approach, 0.8% fewer varicella cases were associated with a 1% increase in the two-dose varicella vaccination rate (p < 0.001), and similar effects were found in both the male and female populations. Conclusions Two-dose varicella vaccination was recommended as an effective health intervention to prevent varicella in Wuxi, China. Varicella vaccination is urgently needed in routine childhood immunisation programs.
THE BEHAVIOUR OF GRANULAR SOILS AT ELEVATED STRESSES

The behaviour of three diverse granular soils (Dogs Bag sand, decomposed granite, and Ham River sand) has been investigated over a wide range of stresses (50 kPa - 58 MPa) allowing a general framework to be developed for the behaviour of granular soils. Characteristic features such as a normal compression and critical state lines may be identified and the description of the mechanics of these soils is therefore similar in many respects to the critical state framework developed for clay soils. For granular soils, the principal means of volumetric compression is through particle crushing and this gives rise to some unusual features, notably that for these soils the critical state is not at the apex of the state boundary surface. Particle breakage has been quantified and unique relationships identified between the degree of breakage and the stresses applied, both for isotropic compression and at the critical state. (A) For the covering abstract see IRRD 859983.
The loop-tail mouse model displays open and closed caudal neural tube defects

ABSTRACT Neural tube defects (NTDs) are the second most common cause of congenital malformations and are often studied in animal models. Loop-tail (Lp) mice carry a mutation in the Vangl2 gene, a member of the Wnt-planar cell polarity pathway. In Vangl2+/Lp embryos, the mutation induces a failure in the completion of caudal neural tube closure, but only a small percentage of embryos develop open spina bifida. Here, we show that the majority of Vangl2+/Lp embryos developed caudal closed NTDs and presented cellular aggregates that may facilitate the sealing of these defects. The cellular aggregates expressed neural crest cell markers and, using these as a readout, we describe a systematic method to assess the severity of the neural tube dorsal fusion failure. We observed that this defect worsened in combination with other NTD mutants, Daam1 and Grhl3. Besides, we found that in Vangl2+/Lp embryos, these NTDs were resistant to maternal folic acid and inositol supplementation. Loop-tail mice provide a useful model for research on the molecular interactions involved in the development of open and closed NTDs and for the design of prevention strategies for these diseases.