Miracle-dz/UniFAR-FTUs huggingface dataset:
The use of extensive reality (XR) for people with moderate to severe intellectual disabilities (ID): A scoping review

BACKGROUND: New technologies have made rapid advances in the field of assistive technologies (AT), with Extended Reality (XR) offering promising results in supporting people with mild intellectual disabilities (ID). Yet, the design and goals of programs for people with mild ID may differ from those for people with moderate and severe ID. It remains unclear how XR technologies are used for people with moderate to severe ID. OBJECTIVE: The study we present in this paper aimed to explore what is known from the existing scientific literature about XR-based interventions for supporting people with moderate to severe intellectual disabilities, including the features of XR content and technology that is used and factors that may impact implementation. METHODS: We conducted a scoping review, searching Cinahl, PubMed, LibSearch, and Google Scholar based on inclusion and exclusion criteria ensuring the focus on XR and moderate to severe ID. We adopted a qualitative content analysis approach to review the papers resulting from the search. RESULTS: In total, we included 16 papers in the review. Most of these focused on XR-based interventions to improve specific skills, such as navigation and daily living skills, in order to increase autonomy and independence. We found a large variety in the content and technology used in these interventions as well as in factors that the authors found to affect the implementation. These factors concern characteristics of users, of caregivers or facilitators, and of the XR environments and systems. The majority of the papers reported studies with small sample sizes, and lacked control groups and follow-up periods to measure long-term effects of XR. CONCLUSIONS: The use of XR for people with moderate to severe ID is an emerging field. Although many authors of the reviewed studies do acknowledge the potential of XR, further evidence is needed. Future research might explore the potential of XR as leisure activity, and might study in detail how features of the XR environment impact behaviour to inform professionals about how to approach their use of XR in order to meet the needs and preferences of people with moderate and severe ID.
The Distribution of Crisis Credit: Effects on Firm Indebtedness and Aggregate Risk

We study the distribution of credit during crisis times and its impact on ﬁrm indebtedness and macroeconomic risk. Whereas policies can help ﬁrms in need of ﬁnancing, they can lead to adverse selection from riskier ﬁrms and higher default risk. We analyze a large-scale program of public credit guarantees in Chile during the COVID-19 pandemic using unique transaction-level data on credit applications, approvals, and loans for the universe of banks and ﬁrms, matched with administrative tax data. The program distributes credit amounting to 4.6% of GDP and increases ﬁrm leverage. Although demand channels credit toward riskier ﬁrms at the micro level, macroeconomic risks remain small. Several factors mitigate aggregate risk: the small weight of riskier ﬁrms, the exclusion of the riskiest ﬁrms, bank screening, contained expected defaults, and the government absorption of tail risk. We quantitatively conﬁrm our empirical ﬁndings with a model of heterogeneous ﬁrms and endogenous default.
Comparative Study of Adverse Drug Reactions Associated with Filgrastim and Pegfilgrastim Using the EudraVigilance Database

Simple Summary The most commonly reported adverse drug reactions (ADRs) related to filgrastim (FIL) and pegfilgrastim (PEG-F) were obtained and analyzed from the European EudraVigilance (EV) database. Frequently reported ADRs for FIL and PEG-F are pyrexia, bone pain, back pain, neutropenia and febrile neutropenia. No statistical difference in the probability of bone pain between FIL and PEG-F was observed. To further depict the safety of FIL and PEG-F, there is a further need to examine the real-life data. Abstract The primary prophylaxis with filgrastim (FIL) and pegfilgrastim (PEG-F) is recommended to decrease the severity of chemotherapy-induced neutropenia (CIN). The commonly reported adverse drug reactions (ADRs) with FIL and PEG-F is bone pain. ADRs pertaining to FIL and PEG-F were extracted from the European EudraVigilance (EV) database. The Individual Case Safety Reports (ICSRs) obtained from EV database that reported FIL and PEG-F as the suspected drug were analyzed. Registered ADRs (from the groups “General disorders and administration site conditions”, “Blood and lymphatic system disorders”, “Musculoskeletal and connective tissue disorders” and “Investigations”) for FIL and PEG-F were collected from EV database from 2007 to 5 June 2021. The reporting odds ratio (ROR) was used to calculate ICSRs with most common ADRs related to FIL and PEG-F. A total of 17,403 ICSRs described the incidence of most common ADRs of FIL and PEG-F. The commonly reported ADRs for both drugs were pyrexia, bone pain, back pain, neutropenia and febrile neutropenia. The odds ratio of ICSRs belonging to the System Organ Class (SOC) “Investigations” (ROR 1.01 (CI 0.93–1.10)) revealed no significant difference in FIL and PEG-F. However, for the SOCs (General disorders and administration site conditions” and “Musculoskeletal and connective tissue disorders” ((ROR 1.14 (CI 1.06–1.21); ROR 1.21 (CI 1.18–1.32), respectively), an increased reporting probability with PEG-F was found. The authors reported a lower reporting probability for the SOC “Blood and lymphatic system disorders” for FIL versus PEG-F (ROR 0.75 (CI 0.70–0.80)). Our results have demonstrated that the occurrence of bone pain was similar with FIL and PEG-F. For the incidence of pyrexia and back pain, PEG-F was associated with a higher reporting probability as compared to FIL. However, the incidence of neutropenia and febrile neutropenia was higher in FIL compared to PEG-F. Further evaluation of data from real life is needed.
Towards an engineering change management maturity grid

Engineering changes are inevitable, and their effective management (ECM) is essential in order for companies to sustain their competitiveness. The challenges in industry on ensuring an efficient ECM have been evident for years. The literature on ECM, however, falls short in giving comprehensive guidance for improvement. This article takes the first steps in developing a holistic maturity framework that is designed to guide improvement effort within ECM. The result of the development, an ECM maturity grid, is presented. The grid is a multilevel framework, and offers maturity assessment on a five-level scale, within five overall process areas, and 26 sub-process areas. A design science approach, aligned with a process for developing maturity grids, is followed to ensure a structured and deliberate approach. The paper contributes furthermore with a comprehensive overview of the critical success factors for an efficient ECM, which is used as basis for identifying the process areas of the maturity grid. Based on an industrial validation by 14 domain experts, it is concluded that the ECM maturity grid offers a valuable basis for providing targeted guidance on how to achieve an efficient ECM. Further development is, however, needed, for the grid to support maturity assessment.
Has the Willingness to Work Fallen during the Covid Pandemic?

We examine the effect of the Covid pandemic on willingness to work along both the extensive and intensive margins of labor supply. Special survey questions in the Job Search Supplement of the Survey of Consumer Expectations (SCE) allow us to elicit information about individuals’ desired work hours for the 2013-2021 period. Using these questions, along with workers’ actual labor market participation, we construct a labor market underutilization measure, the Aggregate Hours Gap (AHG), following Faberman et al. (2020). The AHG captures changes in labor market underutilization for the full population along both the extensive and intensive margins using data on desired work hours as a measure of their potential labor supply. We find that the sharp increase in the AHG during the Covid pandemic essentially disappeared by the end of 2021. We also document a sharp decline in desired work hours during the pandemic that persists through the end of 2021 and is roughly double the drop in the labor force participation rate. Ignoring the decline in desired hours overstates the degree of underutilization by 2.5 percentage points (12.5%). Our findings suggest that, as of 2021Q4, the labor market is tighter than suggested by the unemployment rate and the adverse labor supply effect of the pandemic is more pronounced than implied by the labor force participation rate. These discrepancies underscore the importance of taking into account the intensive margin for both labor market underutilization and potential labor supply.
Time-Dependent Degradation of Naphthoquinones and Phenolic Compounds in Walnut Husks

Simple Summary Some studies have examined the degradation of individual phenolic compounds. However, the degradation of naphthoquinones has been poorly investigated, with contradicting reports. This study investigated how individual phenolic compounds and phenolic groups (e.g., naphthoquinones, flavanols, flavonols, hydroxycinnamic acids) are oxidized over time in walnut husk gratings, to better explain, or confirm, the process of the juglone release pathway. The study was designed to initially determine whether the proposed juglone synthesis pathway of hydrojuglone glucoside → α-hydrojuglone → juglone is indeed correct, or whether an alternative pathway is seen. The study also provides new data about the degradation of individual phenolics and phenolic groups over time when damaged tissue is exposed to the air. As phenolic compounds are considered highly beneficial to human health, increases upon processing indicate the need for further investigations into healthier food preparation processes. Abstract The aim of the present study was to investigate how individual phenolic compounds and phenolic groups in walnut husk gratings (e.g., naphthoquinones, flavanols, flavonols, hydroxycinnamic acids) are oxidized over time, with a particular focus on the juglone synthase pathway. Walnut husk gratings were prepared and left under ‘degradation’ conditions (exposure to the air, room temperature) at increasing times. Following methanol extraction of these husk gratings, the HPLC profile of methanolic extract of husk gratings exhibited twenty-six compounds over time, then hydrojuglone glucoside, α-hydrojuglone, and juglone were detailed by HPLC-mass spectrometry. Initially (0–20 min), the content of hydrojuglone glucoside in the husk gratings decreased by 40.4%, while the content of α-hydrojuglone increased by 20.0%, and then decreased. After an initial delay (0–20 min), juglone increased by 47.9% from 20 to 40 min, and then decreased. This initially confirmed that hydrojuglone glucoside and α-hydrojuglone could be considered as precursors of juglone. Different phenolic groups showed different degradation processes, although they all reached their highest content after 40 min. This might arise from degradation of the phenols, increased free phenols, or activation of the plant defense mechanism due to damage to the tissue, similar to the effects of stress or a pathogen attack. Although it has been reported that the phenolic compounds decrease when food is processed or damaged, they showed increases, which were not indefinite, but time dependent. As phenolic compounds are considered highly beneficial to human health, increases upon processing indicate the need for further investigations into healthier food preparation processes. This is the first study on the degradation pathways of juglone, using a mass spectrometer, in which we suggest that hydrojuglone glucoside and α-hydrojuglone are indeed the precursors of juglone. However, it is possible that there are other degradation pathways of hydrojuglone glucoside, since less juglone is synthesized than expected.
New Method of Avoiding Underestimation of Caries Incidence and Its Association with Possible Risk Factors in Japanese University Students: A Prospective Cohort Study

The objective of this three-year prospective cohort study was to investigate the association between a new definition of an increase in dental caries and risk factors in Japanese young adults. Data of Okayama University students who volunteered to undergo oral examinations and answer questionnaires in 2015 and 2018 were analyzed. The status of filled teeth and the status of occlusal/proximal surfaces of filled or decayed teeth were recorded. An increase in dental caries was defined as a change in the status of filled teeth and/or an increase in dental caries of occlusal and proximal surfaces. A total of 393 participants (18.2 ± 0.8 years) were analyzed. First and second molars showed a high prevalence of dental caries. Of the participants, 144 (36.6%) showed an increase in dental caries. In all the participants and in the females, the decayed, missing, and filled teeth (DMFT) score and history of orthodontic treatment at baseline were significantly associated with an increase in dental caries (p < 0.05) in logistic regression analyses. In the males, the DMFT score and the daily frequency of snacking (≥2) at baseline were significantly associated with an increase in dental caries (p = 0.04). The DMFT score and history of orthodontic treatment at baseline can be risk factors for an increase in dental caries using the new definition in young adults.
Shp2 suppresses fat accumulation in white adipose tissue by activating Wnt/β-catenin signaling following vertical sleeve gastrectomy in obese rats with type-2 diabetes

Adipogenesis and fat accumulation are closely associated with the development of obesity. Sleeve gastrectomy (SG) is an effective treatment for obesity and associated metabolic disorders. Leptin is downregulated after SG and Src homology phosphatase 2 (Shp2) has an important role in leptin signaling. The role of Shp2 in SG and the mechanisms of fat reduction following SG were further investigated in the current study. Sham and SG operations were performed on obese type-2 diabetes model Sprague-Dawley rats. Primary pre-adipocytes were isolated from the inguinal white adipose tissue (ingWAT) of the rats. Shp2 expression in ingWAT pre-adipocytes was silenced using small interfering RNA transfection. Shp2 function was inhibited using the specific inhibitor, SHP099. In addition, Shp2 was overexpressed using lentivirus. Gene and protein expression analysis was performed after adipocyte differentiation. Furthermore, Shp2-overexpressing ingWAT pre-adipocytes treated with the β-catenin inhibitor, PNU-74654, were also used for gene and protein expression analysis. Adipogenic markers, including triglycerides, peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein α (Cebpα), adiponectin, fatty acid-binding protein 4 and leptin, were examined. Compared with the sham, triglyceride, leptin, PPARγ and Cebpα levels were significantly reduced in the ingWAT from the SG group. Shp2 expression levels were reduced following leptin treatment. Moreover, genetic analysis demonstrated depot-specific adipogenesis following Shp2 silencing or inhibition in ingWAT pre-adipocytes. Conversely, Shp2 overexpression decreased the expression of adipogenic markers by enhancing β-catenin expression. PNU-74654 treatment abolished the downregulation of adipogenic markers caused by Shp2 overexpression. SG decreased leptin levels in ingWAT, which in turn upregulated Shp2, and Shp2 suppressed fat accumulation and adipogenic differentiation by activating the Wnt/β-catenin signaling pathway. Overall, this may represent a potential mechanism of fat reduction in SG, and Shp2 may serve as a potential therapeutic target for the treatment of obesity and type-2 diabetes.
Characterization of Conjunctival Sac Microbiome from Patients with Allergic Conjunctivitis

Conjunctival sac microbiome alterations have been reported to be closely associated with many ocular diseases. However, the characteristic of conjunctival sac microbiome in allergic conjunctivitis (AC) was scarcely described. In this study, we aimed to identify the differences of the conjunctival sac microbiome composition in AC patients compared with normal controls (NCs) using high-throughput 16S rDNA sequencing metagenomic analysis. The conjunctival sac microbiome samples from 28 AC patients and 39 NC patients were collected. The V3-V4 region of 16S rRNA gene high-throughput sequencing was performed on the illumina MiSeq platform. Alpha diversity, beta diversity and the relative abundance at the phylum and genus levels were analyzed using QIIME. Alpha diversity demonstrated by Chao1, Observed_species and PD_whole_tree indexes did not show significant difference between the AC and NC groups, while the Shannon index was higher in the AC group. Beta diversity showed divergent microbiome composition in different groups (p < 0.005). The top five abundant phyla were Firmicutes, Proteobacteria, Actinobacteriota, Bacteroidota and Cyanobacteria in both groups. The top five abundant genera were Bacillus, Staphylococcus, Corynebacterium, Acinetobacter and Ralstonia in the AC group and Acinetobacter, Staphylococcus, Bacillus, Clostridium_sensu_stricto_1, Corynebacterium and Geobacillus in the NC group. The Firmicutes/Bacteroidetes (F/B) ratio at the phylum level was similar between groups (p = 0.144). The Bacillus/Acinetobacter (B/A) ratio at the genus level was higher in the AC group (p = 0.021). The dysbiosis detected in this study might provide further evidence to investigate the mechanism and treatment methods for allergic conjunctivitis.
CRISM‐Based High Spatial Resolution Thermal Inertia Mapping Along Curiosity's Traverses in Gale Crater

Thermal inertia is a key summary property describing the thermophysical characteristics of geologic materials. Orbital estimates of thermal inertia are especially useful in conjunction with rover‐based observations to provide additional constraints on material properties and to interpret the broader region surrounding the traverse. We have developed an approach to estimate apparent thermal inertias (ATI) from observations from the Mars Reconnaissance Orbiter's Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) at a much higher spatial resolution than is available from any other orbital data set. We apply this method to along‐track oversampled scene FRT00021C92 over Gale Crater within Glen Torridon, where the Curiosity rover has traversed; the retrieved values are then analyzed along with remote sensing and in‐situ observations by Curiosity to characterize surface properties in and around Glen Torridon. CRISM‐based ATI estimates of basaltic sand fields indicate a correlation between higher ATI values and the abundance of large (up to 3 mm in size) grains on the crests and flanks of large ripples. On the Vera Rubin ridge, ATI estimates are used to identify a west‐to‐east increase in the abundance of rock fragments within unconsolidated surface cover. On the Greenheugh pediment, an unmixing approach is used to identify a thin layer of wind‐blown sand sourced from the nearby Sands of Forvie. Finally, within Glen Torridon, a north‐to‐south increase in the mean and width of the ATI distribution is identified as a consequence of increased bench‐like bedrock exposures.
Correlation between Positive Orientation and Control of Anger, Anxiety and Depression in Nursing Students in Poland, Spain and Slovakia during the COVID-19 Pandemic

(1) This study analysed the relationship between positive orientation and subjective control of anger, anxiety and depression in nursing students in Poland, Spain and Slovakia during the pandemic. (2) The survey was carried out by the diagnostic survey method in a group of 756 nursing students in Poland, Spain and Slovakia. The empirical data were gathered using an original survey questionnaire, the Positive Orientation Scale and the Courtauld Emotional Control Scale. (3) It was shown that the positive orientation level in Polish students was significantly lower than in students in Spain (p < 0.0001) and Slovakia (p < 0.0001). Low results for positive orientation were obtained in nearly half (47.18%) of the respondents in the Polish sample, whereas it was 34.18% and 31.18% in the Spanish and Slovak samples, respectively (p < 0.0001). A positive orientation was the most important predictor of emotional control among the nursing students at all the sites (p < 0.0001). (4) Positive orientation has been shown to have a significant impact on emotional control in nursing students during the pandemic. Therefore, it is important to carefully monitor students’ mental health during the pandemic to determine the demand for psychological and emotional support.
Magnetostructural Dependencies in 3d2 Systems: The Trigonal Bipyramidal V3+ Complex

We introduce a multiconfigurational approach to study the magnetostructural correlations in 3d2 systems. The theoretical framework represents a restricted active space self‐consistent field method, with active space optimized to the number of all non‐bonding orbitals. To demonstrate the validity and effectiveness of the method, we explore the physical properties of the trigonal bipyramidal spin‐one single‐ion magnet (C6F5)3trenVCNtBu . The obtained theoretical results show good agreement with the experimental data available in the literature. This includes measurements for the magnetization, low‐field susceptibility, continuous wave electron paramagnetic resonance, and photoluminescence spectroscopy. The proposed method may be reliably applied to a variety of 3d2 magnetic systems. To this end, and for the sake completeness, we provide detailed analytical and numerical representations for the generic Hamiltonian's effective matrix elements related to the crystal field, exchange, spin–orbit, and Zeeman interactions.
The Rate of Clinical Outcomes in Atrial Fibrillation according to Antithrombotic Strategy: The COOL-AF Registry

Background Ischemic stroke/transient ischemic attack (TIA), major bleeding, and death are common outcomes in atrial fibrillation (AF) patients, so appropriate antithrombotic therapy is crucial. The objective of this study was to investigate the rate of ischemic stroke/TIA, major bleeding, and death compared among AF patients who received oral anticoagulant (OAC) alone, antiplatelet alone, or OAC plus antiplatelet. Methods Prospective data from the COOL-AF Registry (Thailand's largest multicenter nationwide AF registry) were analyzed. Clinical, laboratory, and medication data were collected at baseline and during follow-up. Clinical outcomes, including ischemic stroke/TIA, major bleeding, and death, were collected. Results There were 3,148 patients included. Mean age was 68.1 ± 10.8 years and 1,826 (57.7%) were male. AF was paroxysmal in 998 (31.7%), persistent in 603 (19.2%), and permanent in 1,547 (49.1%). The mean follow-up duration was 25.7 ± 10.6 months. The median rates of ischemic stroke/TIA, major bleeding, and death were 1.49 (1.21-1.81), 2.29 (1.94-2.68), and 3.89 (3.43-4.40) per 100 person-years. Antiplatelet alone, OAC plus antiplatelet, and OAC alone were used in 582 (18.5%), 308 (9.8%), and 2,258 (71.7%) patients, respectively. Antiplatelet alone significantly increased the risk of ischemic stroke/TIA and death compared to OAC alone. OAC plus antiplatelet significantly increased the risk of death compared to OAC alone. Conclusions Antiplatelet was used in 890 (28.3%) AF, of whom 582 (18.5%) received antiplatelet alone, and 308 (9.8%) received antiplatelet and OAC. OAC plus antiplatelet significantly increased the risk of death without additional stroke prevention benefit. Antiplatelet alone should not be used in patients with AF.