Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment perspective after failed open reduction of congenital hip dislocation. A systematic review

Background Failure of open reduction of developmental hip dislocation is a serious complication and revision surgery appear to be technically demanding with high complication rates. Little attention has been given in literature to patients in whom open reduction of developmental hip dislocation has failed. We present a systematic review about current perspectives and timing when to perform surgical revision after failed open reduction of developmental hip dislocation in children. Methods Following the recommendations of the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses” (PRISMA) statements we performed a comprehensive search of the PubMed and Google Scholar bibliographic database in order to select all studies published between 1980 and 2022. Studies were screened for the reasons for failure of open reduction, timing when revision surgery was performed, and for the surgical techniques used for revision. Results A total of 10 articles including 252 patients and 268 hips has been recorded. The most common causes of re-dislocation after open reduction are inadequate exposure and failure to release the obstructing soft tissues inside and around the hip. In 90% of the cases the anterolateral approach was performed for revision surgery. Avascular necrosis occurred in 5%–67% of cases and was the most encountered complication. Conclusion Redislocation of developmental hip dislocation after an open reduction has poor long-term outcomes mainly due to a high rate of avascular necrosis of the femoral head. It is mandatory to obtain a stable reduction at the second surgery combining soft tissue release, capsulorrhaphy, pelvic and femoral osteotomies.
A Study of Product Quality and Marketing Efforts in Closed-Loop Supply Chains With Remanufacturing

In this paper, the closed-loop supply chain (CLSC) models are extended to consider the case that the manufacturer can improve the product quality and the retailer can have effective marketing activities to promote the product. One centralized and three decentralized CLSC models are mathematically formulated in this paper. For the centralized CLSC model, the optimal solutions are derived in closed-form format analytically. For three decentralized CLSC models, by assuming the manufacturer is the leader, the equilibrium solutions are also obtained in closed-form format under the Stackelberg game settings. Based on the optimal/equilibrium solutions and the corresponding objective function values for the proposed models, several interesting managerial insights, and economic implications are obtained. Moreover, the proposed models with product quality improvement and marketing efforts are compared with the models with only product quality improvement effort and the models with only marketing effort. The results show that the performance of the proposed models with both product quality improvement and marketing efforts is better in the decentralized CLSC models.
Storm Track Response to Perturbations in Climate

This thesis advances our understanding of midlatitude storm tracks and how they respond to perturbations in the climate system. The midlatitude storm tracks are regions of maximal turbulent kinetic energy in the atmosphere. Through them, the bulk of the atmospheric transport of energy, water vapor, and angular momentum occurs in midlatitudes. Therefore, they are important regulators of climate, controlling basic features such as the distribution of surface temperatures, precipitation, and winds in midlatitudes. Storm tracks are robustly projected to shift poleward in global-warming simulations with current climate models. Yet the reasons for this shift have remained unclear. Here we show that this shift occurs even in extremely idealized (but still three-dimensional) simulations of dry atmospheres. We use these simulations to develop an understanding of the processes responsible for the shift and develop a conceptual model that accounts for it. We demonstrate that changes in the convective static stability in the deep tropics alone can drive remote shifts in the midlatitude storm tracks. Through simulations with a dry idealized general circulation model (GCM), midlatitude storm tracks are shown to be located where the mean available potential energy (MAPE, a measure of the potential energy available to be converted into kinetic energy) is maximal. As the climate varies, even if only driven by tropical static stability changes, the MAPE maximum shifts primarily because of shifts of the maximum of near-surface meridional temperature gradients. The temperature gradients shift in response to changes in the width of the tropical Hadley circulation, whose width is affected by the tropical static stability. Storm tracks generally shift in tandem with shifts of the subtropical terminus of the Hadley circulation. We develop a one-dimensional diffusive energy-balance model that links changes in the Hadley circulation to midlatitude temperature gradients and so to the storm tracks. It is the first conceptual model to incorporate a dynamical coupling between the tropical Hadley circulation and midlatitude turbulent energy transport. Numerical and analytical solutions of the model elucidate the circumstances of when and how the storm tracks shift in tandem with the terminus of the Hadley circulation. They illustrate how an increase of only the convective static stability in the deep tropics can lead to an expansion of the Hadley circulation and a poleward shift of storm tracks. The simulations with the idealized GCM and the conceptual energy-balance model demonstrate a clear link between Hadley circulation dynamics and midlatitude storm track position. With the help of the hierarchy of models presented in this thesis, we obtain a closed theory of storm track shifts in dry climates. The relevance of this theory for more realistic moist climates is discussed.
Ultrafast and low-temperature synthesis of patternable MoS2 using laser irradiation

The fascinating properties of transition metal dichalcogenides have been studied for a decade to broaden their promising applications as flexible electronics. However, conventional mass production of 2D materials is carried out at relatively high temperatures over 600 °C, which typical flexible substrates cannot withstand. For this reason, proper low-temperature synthesis methods must be developed. Here, we propose a fast and low-temperature synthesis method for metallic MoS2, which can be achieved on a flexible polyethylene terephthalate (PET) substrate. A precursor solution was prepared by a mixture of (NH4)2MoS4 powder and dimethylformamide. This solution was then coated on the silicon or PET substrate and an MoS2 film can be fabricated in unconstrained patterns such as lines or a continuous film at micro scale. The necessary laser power and exposure time were confirmed from systematic Raman spectroscopy measurements. The metallic behavior of the synthesized film was demonstrated by the electrical device fabrication and these excellent metallic properties show the feasibility of using MoS2 as a patternable electrode material on flexible substrates.
Whole Genome Sequencing and Molecular Epidemiology of Clinical Isolates of Staphylococcus aureus from Algeria

Staphylococcus aureus is an important pathogen responsible for various healthcare- and community-acquired infections. In this study, whole genome sequencing (WGS) was used to genotype S. aureus clinical isolates from two hospitals in Algeria and to characterize their genetic determinants of antimicrobial resistance. Seventeen S. aureus isolates were included in this study. WGS, single-nucleotide polymorphism (SNP)-based phylogenetic analysis, in silico multilocus sequence typing (MLST), spa and staphylococcal cassette chromosome mec (SCCmec) typing and in silico antimicrobial resistance profiling were performed. Phenotypic antibiotic susceptibility testing was performed using the Vitek 2 system and the disk diffusion method. The isolates were separated into sequence types (STs), with ST80 being predominant; five clonal complexes (CCs); four spa types (t044, t127, t368, t386); and two SCCmec types (IVc and IVa). Whole genome analysis revealed the presence of the resistance genes mecA, blaZ, ermC, fusB, fusC, tetK, aph(3′)-IIIa and aad(6) and mutations conferring resistance in the genes parC and fusA. The rate of multidrug resistance (MDR) was 64%. This work provides a high-resolution characterization of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolates and emphasizes the importance of continuous surveillance to monitor the spread of S. aureus in healthcare settings in the country.
Misinterpreted Seismic Evidence for Localized Rapid Changes of the Inner Core Boundary Surface

The nature of the inner core (IC) temporal changes is of great importance in understanding the deep earth dynamics. The comment by Tian and Wen (2023, https://doi.org/10.1029/2023gl103173) on our previous paper (Yang & Song, 2022, https://doi.org/10.1029/2022gl098393) provided a new observation as evidence against the IC rotation and proposed that our observations are instead from localized rapid changes at the IC surface. Here we argue the opposite to its conclusions. The comment misinterpreted our logic and many of our observations and arguments. Its one new waveform does not contradict with the “rotation” model. The original evidence for the “surface” model is demonstrated to be an artifact from station clock errors and instrument changes. Additionally, the surface model lacks a solid physical and quantitative basis to explain existing seismic evidence. We conclude that the rotation model is currently the best interpretation and the surface model is not a viable alternative.
Environment conscious control of Fusarium Oxysporum F. sp. Lycopersici-induced tomato wilt using bio agents, phytochemicals and their combination in marked contrast to chemical

Tomato ( Lycopersicon esculentum ) is one of the most significant vegetable crops cultivated in 4.5 million hectares with an output of 115.5 million metric tonnes globally. India ranked third internationally in terms of output and area with production of 333.25 metric tonnes from an area of 27.56 million hectares. Several diseases limit the output of tomatoes leading to 100 percent yield losses. Among all diseases, wilt caused by Fusarium oxysporum f. sp . lycopersici (FOL) is the most destructing in both greenhouse and field environments. Hence, a study was carried out at during Rabi seasons in 2020-2022 at Laboratory and
The British Lower Palaeolithic: Stones in Contention

Taking as its central theme the issue of whether early Hominins organized themselves into societies as we understand them, John McNabb looks at how modern researchers recognize such archaeological cultures. He examines the existence of a stone tool culture called the Clactonian to introduce the multidisciplinary nature of the subject. In analyzing the various kinds of data archaeologists would use to investigate the existence of a Palaeolithic culture, this book represents the latest research in archaeology, population dispersals, geology, climatology, human palaeontoloty, evolutionary psychology, environmental and biological disciplines and dating techniques, along with many other research methods.
Investigation of the Potential Phlorotannins and Mechanism of Six Brown Algae in Treating Type II Diabetes Mellitus Based on Biological Activity, UPLC-QE-MS/MS, and Network Pharmacology

Type 2 diabetes mellitus (T2DM) has developed into an important health concern worldwide. The discovery of phlorotannins and their efficacy in the treatment of T2DM has become a hotspot for research in various fields. In this study, the potential phlorotannins and mechanism of six brown algae against T2DM were in-depth investigated using biological activity assays, LC-MS, and network pharmacology. First, the ethyl acetate fraction (EA frac.) showed high polyphenolic content and possessed significantly antioxidant and enzyme inhibitory abilities. Further, a total of fifty-nine peaks were obtained from six EA fracs. via UPLC-QE-MS/MS analysis, and fifteen of them were identified as phlorotannins and their isomers or derivatives. In detail, the chemical structures of six phlorotannins were inferred as dibenzodioxine-1,3,6,8-tetraol, bifuhalol, dioxinodehydroeckol, eckol, fucofurodiphlorethol, and fucotriphlorethol; three phlorotannin isomers were deduced to be fucophlorethol, trifucol, triphlorethol A, or triphlorethol B; and the phlorotannin derivative of m/z 263 was determined to be dibenzodioxine-1,2,3,6,8-pentanol or dibenzodioxine-1,2,4,5,7-pentanol. Moreover, 43 T2DM-related targets acted on by these chemicals were identified, and the function of phlorotannin to prevent and treat T2DM was elucidated in a holistic way based on the established compound-target-disease network, and GO function and KEGG pathway enrichment analysis.
Semantic Segmentation in Thermal Videos: A New Benchmark and Multi-Granularity Contrastive Learning-Based Framework

Video semantic segmentation has achieved great success, which is significant for road scene understanding. However, semantic segmentation remains challenging in poor illumination and inclement weather. Thermal camera, highly invariant to light and highly penetrating to rain and fog, enables semantic segmentation to work under challenging conditions. Thus, this paper explores semantic segmentation in thermal videos to broaden the scope of the application of road scene understanding. We offer the first thermal video semantic segmentation dataset TVSS including 1695 thermal videos with 50850 frames in road scenes. It is available at: https://xzbai.buaa. edu.cn/datasets.html. TVSS is finely annotated by 17 categories at the frame rate of 1fps, with a labeled pixel density of 98.9%. Existing video semantic segmentation methods rely on the amount of labels and the representation power of backbones, which cannot achieve ideal results on thermal videos. Thus, we introduce a multi-granularity contrastive learning based thermal video semantic segmentation model (MGCL), which explores the abundant unlabeled frames to boost the supervised segmentation. Specifically, MGCL constructs multi-granularity self-supervised signals on unlabeled thermal videos by contrastive learning, including the intra-frame context generalization loss, the intra-clip temporal consistency loss, and the inter-video category discrimination loss. In addition, a hard anchor sampling strategy is introduced to focus on hard-classify pixels for further performance improvement. Extensive experiments on TVSS demonstrate the superior performance of MGCL in both accuracy and efficiency. Compared to the 12 state-of-the-art semantic segmentation methods, MGCL achieves 2.8% to 8.1% gains in mIoU performance while maintaining the inference speed.
Crataeva nurvala Bark (Capparidaceae) Extract Modulates Oxidative Stress-Related Gene Expression, Restores Antioxidant Enzymes, and Prevents Oxidative Stress in the Kidney and Heart of 2K1C Rats

Objective Crataeva nurvala is a medicinal plant, which contains a wide range of polyphenolic and bioactive compounds. The aim of the study was to evaluate the renal-protective activity of Crataeva nurvala in two-kidney, one-clip (2K1C) rats. Methods In this study, the ethanol extract of Crataeva nurvala bark at a dose of 100 mg/kg was orally used to treat 2K1C rats for four weeks. At the end of the experiment, all rats were sacrificed and tissue samples were collected for further biochemical and histological assessments. Results This investigation showed that Crataeva nurvala treatment prevented the kidney dysfunction in 2K1C rats. Uric acid and creatinine concentration and CK-MB activities increased in 2K1C rats which were normalized by Crataeva nurvala. 2K1C rats also showed increased oxidative stress, depicted by the elevated level of MDA, NO, and APOP in plasma and tissues. Oxidative stress parameters declined in 2K1C rats by the treatment of Crataeva nurvala. These results could be attributed to the restoration of antioxidant enzyme activities such as catalase and SOD. Crataeva nurvala extracts also upregulated antioxidant gene expression in the kidneys of 2K1C rats. Moreover, several anti-inflammatory genes were suppressed by Crataeva nurvala treatment in 2K1C rats. Furthermore, fibrosis and collagen deposition in the kidneys were also lowered by the treatment of the Crataeva nurvala extract. Conclusion The experimental data suggest that the Crataeva nurvala extract protected renal damage and oxidative stress, probably by restoring antioxidant enzymes activities in 2K1C rats.
VALVULAR AND STRUCTURAL HEART DISEASES Original Studies Gender-Related Clinical and Echocardiographic Outcomes at 30-Day and 12-Month Follow up After MitraClip Implantation in the GRASP Registry

Guilherme F. Attizzani, MD, Yohei Ohno, MD, Davide Capodanno,* MD, PhD, Stefano Cannata, MD, Fabio Dipasqua, MD, Sebastiano Imm e, MD, Sarah Mangiafico, MD, Marco Barbanti, MD, Margherita Ministeri, MD, Anna Cageggi, MD, Anna Maria Pistritto, MD, Sandra Giaquinta, MD, Silvia Farruggio, MD, Marta Chiarand a, MD, Giuseppe Ronsivalle, MD, Salvatore Scandura, MD, Corrado Tamburino, MD, PhD, Piera Capranzano, MD, PhD, and Carmelo Grasso, MD
‘Dear Epsom’: a poetic autoethnography on campus as home of an international doctoral student in Aotearoa New Zealand

This article delineates my place attachment and sense of home in my Epsom campus, University of Auckland, in Aotearoa New Zealand, where I studied for my PhD in two periods of time: during the first year of my PhD programme, when my sense of home was established; and when I returned to Vietnam for my six-month research trip and was stranded due to the Covid-19 pandemic, leading to my sense of home in my campus being weakened and disrupted. Using poetic autoethnography as the methodology, I recount my personal experiences of how I grew attached to my university campus as a physical place, and social spaces of cultural diversity, friendship, and academic and PhD student identity development. The article offers an analysis of my unique emotional experience of being on and off campus involuntarily, which is hardly found in extant literature on international student mobility and students’ lived experiences.
An Unusual Presentation of Candidal Onychomycosis: A Case Report

Onychomycosis can present with various manifestations such as subungual hyperkeratosis, onycholysis, and nail plate destruction. Here we present a case of a 61-year-old African male with a known case of type 2 diabetes mellitus on insulin. He worked as a mechanic and presented with nail changes that started four months prior to presentation and worsened over time, mainly affecting the fingernails of bilateral hands. On examination, there was yellowish to greenish discoloration with very extensive hyperkeratosis of skin around the fingers and nails that caused avulsion of nails. Swab and culture showed Candida albicans +3. Nail and skin biopsy showed bacterial colony with fungal hypha. The patient showed marked improvement after receiving oral fluconazole 300 mg weekly for three months.
Circulating MicroRNAs as Biomarker for Vessel-Associated Retinal Diseases

Introduction: Vessel-associated retinal diseases are a major cause of blindness and severe visual impairment. The identification of appropriate biomarkers is of great importance to better anticipate disease progression and establish more targeted treatment options. MicroRNAs (miRNAs) are short, single-stranded, noncoding ribonucleic acids that are involved in the posttranscriptional regulation of gene expression through hybridization with messenger RNA. The expression of certain miRNAs can be different in patients with pathological processes and can be used for the detection and differentiation of various diseases. In this study, we investigate to what extent previously in vitro identified miRNAs are present as cell-free circulating miRNAs in the serum and vitreous of human patients with and without vessel-associated retinal diseases. Methods: Relative quantification by quantitative real-time polymerase chain reaction was used to analyze miRNA expression in patients with vessel-associated retinal diseases such as age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinal vein occlusion compared with control patients. Results: In serum samples, miR-29a-3p and miR-192-5p showed increased expression in patients with neovascular AMD relative to control patients. Similarly, miR-335-5p, miR-192-5p, and miR-194-5p showed increased expression in serum from patients with proliferative DR. In vitreous samples, miR-100-5p was decreased in patients with proliferative DR. Differentially expressed miRNAs showed good diagnostic accuracy in receiver operating characteristic (ROC) and area under the ROC curve analysis. Conclusion: The miRNAs investigated in this study may have the potential to serve as biomarkers for vessel-associated retinal diseases. Combining multiple miRNAs may enhance the predictive power of the analysis.
Skillful Multiyear Prediction of the Kuroshio and Gulf Stream Jets and Eddy Activity

The Kuroshio and Gulf Stream (GS), Northern Hemisphere warm ocean currents, have narrow bands of intense jets and vigorous eddies. While the importance of them in regulating physical and biological ocean systems and climate has been increasingly recognized, the operational predictability of year‐to‐year variations in these jets and eddies has not been quantitatively assessed yet. Through a series of experiments using an eddy‐resolving dynamical ocean forecasting system, here we show that observed year‐to‐year variations in the intensities of the jets and eddies in the Kuroshio Extension and GS regions can be skillfully predicted up to a lead time of about 2 years. Sources of predictability mostly come from initial ocean memories, and variations in local atmospheric conditions play a secondary role. Our results demonstrate that the observed multiyear variations in ocean jets and eddies in these regions are operationally predictable when ocean models are properly initialized with sufficient spatial resolution.
Acute Kidney Injury and Sepsis after Cardiac Surgery: The Roles of Tissue Inhibitor Metalloproteinase-2, Insulin-like Growth Factor Binding Protein-7, and Mid-Regional Pro-Adrenomedullin

Background: Identifying a panel of markers detecting kidney injury before the glomerular filtration rate reduction is a challenge to improving the diagnosis and management of acute kidney injury (AKI) in septic patients. This study evaluated the roles of tissue inhibitor metal proteinase-2, insulin growth factor binding protein-7 (TIMP2*IGFBP7), and mid-regional pro-adrenomedullin (MR-proADM) in patients with AKI. Patients and Methods: This study was prospectively conducted in an intensive care unit (ICU) enrolling 230 patients who underwent cardiac surgery. Biomarkers were evaluated before and after 4 h of the cardiac surgery. Results: Whereas urine and creatinine alterations appeared at 23.2 (12.7–36.5) hours after cardiac surgery, urinary TIMP2*IGBP7 levels were higher at 4 h in AKI patients (1.1 ± 0.4 mg/L vs. 0.08 ± 0.02 mg/L; p < 0.001). Its concentration > 2 mg/L increases AKI risk within the following 24 h, clearly identifying the population at high risk of renal replacement therapy (RRT). In patients with sepsis, MR-proADM levels were 2.3 nmol/L (0.7–7.8 nmol/L), with the highest values observed in septic shock patients (5.6 nmol/L (3.2–18 nmol/L)) and a better diagnostic profile than procalcitonin and C-reactive protein to identify septic patients. MR-proADM values > 5.1 nmol/L and urine TIMP2*IGBP7 levels > 2 mg/L showed a significantly faster progression to RRT, with a mean follow-up time of 1.1 days. Conclusions: TIMP2*IGBP7 and MR-proADM precociously diagnose AKI in septic patients after cardiac surgery, giving prognostic information for RRT requirement.