Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Heavy Slow Resistance Training Combined With Corticosteroid Injections or Tendon Needling in Patients With Lateral Elbow Tendinopathy: A 3-Arm Randomized Double-Blinded Placebo-Controlled Study

Background: Lateral elbow tendinopathy is a disabling tendon overuse injury. It remains unknown if a corticosteroid injection (CSI) or tendon needling (TN) combined with heavy slow resistance (HSR) training is superior to HSR alone in treating lateral elbow tendinopathy. Purpose/Hypothesis: The purpose was to investigate the effects of HSR combined with either (1) a CSI, (2) TN, or (3) placebo needling (PN) as treatment for lateral elbow tendinopathy. We hypothesized that 12 weeks of HSR in combination with a CSI or TN would have superior effects compared with PN at 12, 26, and 52 (primary endpoint) weeks’ follow-up on primary (Disabilities of the Arm, Shoulder and Hand [DASH] score) and secondary outcomes in patients with chronic unilateral lateral elbow tendinopathy. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 60 patients with chronic unilateral lateral elbow tendinopathy were randomized to perform 12 weeks of home-based HSR with elastic band exercises combined with either (1) a CSI, (2) TN, or (3) PN, and at 12, 26, and 52 weeks, we assessed the primary outcome, the DASH score, and secondary outcomes: shortened version of the DASH (QuickDASH) score, pain (numerical rating scale [NRS] score), pain-free grip strength, and hypervascularization (power Doppler area). Results: A CSI, TN, and PN improved patient outcomes equally based on the DASH (Δ20 points), QuickDASH (Δ21 points), and NRS (Δ2.5 points) scores after 12 weeks. Further, after 12 weeks, a CSI also resulted in decreased hypervascularization (power Doppler area) compared with PN (Δ–2251 pixels, P = .0418). Except for the QuickDASH score (CSI increased score by Δ15 points compared with PN; P = .0427), there were no differences between the groups after 52 weeks. Conclusion: These results suggest that 12 weeks of HSR improved symptoms in both the short and the long term and that a CSI or TN did not amplify this effect. In addition, a CSI seemed to impair patient-reported outcomes compared with HSR alone at long-term follow-up. Registration: NCT02521298 (ClinicalTrials.gov identifier).
Awareness With Paralysis Among Critically Ill Emergency Department Patients: A Prospective Cohort Study*

OBJECTIVES: In mechanically ventilated patients, awareness with paralysis (AWP) can have devastating consequences, including post-traumatic stress disorder (PTSD), depression, and thoughts of suicide. Single-center data from the emergency department (ED) demonstrate an event rate for AWP factors higher than that reported from the operating room. However, there remains a lack of data on AWP among critically ill, mechanically ventilated patients. The objective was to assess the proportion of ED patients experiencing AWP and investigate modifiable variables associated with its occurrence. DESIGN: An a priori planned secondary analysis of a multicenter, prospective, before-and-after clinical trial. SETTING: The ED of three academic medical centers. PATIENTS: Mechanically ventilated adult patients that received neuromuscular blockers. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: All data related to sedation and analgesia were collected. AWP was the primary outcome, assessed with the modified Brice questionnaire, and was independently adjudicated by three expert reviewers. Perceived threat, in the causal pathway for PTSD, was the secondary outcome. A total of 388 patients were studied. The proportion of patients experiencing AWP was 3.4% (n = 13), the majority of whom received rocuronium (n = 12/13; 92.3%). Among patients who received rocuronium, 5.5% (n = 12/230) experienced AWP, compared with 0.6% (n = 1/158) among patients who did not receive rocuronium in the ED (odds ratio, 8.64; 95% CI, 1.11–67.15). Patients experiencing AWP had a higher mean (sd) threat perception scale score, compared with patients without AWP (15.6 [5.8] vs 7.7 [6.0]; p < 0.01). CONCLUSIONS: AWP was present in a concerning proportion of mechanically ventilated ED patients, was associated with rocuronium exposure in the ED, and led to increased levels of perceived threat, placing patients at greater risk for PTSD. Studies that aim to further quantify AWP in this vulnerable population and eliminate its occurrence are urgently needed.
Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice

Abstract Serine proteases (PRSS) constitute nearly one-third of all proteases, and many of them have been identified to be testis-specific and play significant roles during sperm development and male reproduction. PRSS54 is one of the testis-specific PRSS in mouse and human but its physiological function remains largely unclear. In the present study, we demonstrate in detail that PRSS54 exists not only in testis but also in mature sperm, exhibiting a change in protein size from 50 kDa in testis to 42 kDa in sperm. Loss of PRSS54 in mice results in male subfertility, acrosome deformation, defective sperm–zona penetration, and phenotypes of male subfertility and acrosome deformation can be rescued by Prss54 transgene. Ultrastructure analyses by transmission electronic microscopy further reveal various morphological abnormalities of Prss54–/– spermatids during spermiogenesis, including unfused vacuoles in acrosome, detachment and eccentrical localization of the acrosomal granules, and asymmetrical elongation of the nucleus. Subcellular localization of PRSS54 display that it appears in the acrosomal granule at the early phase of acrosome biogenesis, then extends along the inner acrosomal membrane, and ultimately presents in the acrosome region of the mature sperm. PRSS54 interacts with acrosomal proteins ZPBP1, ZPBP2, ACRBP, and ZP3R, and loss of PRSS54 affects the distribution of these proteins in testis and sperm, although their protein levels are largely unaffected. Moreover, Prss54–/– sperm are more sensitive to acrosome reaction inducers. Summary Sentence These data indicate that PRSS54 is an acrosomal protein and plays an important role in regulating acrosome biogenesis, sperm function, and male fertility. Graphical Abstract
Teamwork in home care nursing: A scoping literature review

Abstract Due to an increased number of complex multi‐ and long‐term ill patients, healthcare and nursing provided in patients' homes are expected to grow. Teamwork is important in order to provide effective and safe care. As care becomes more complex, the need for teamwork in home care nursing increases. However, the literature on teamwork in the patients' home environment is limited. The aim of this study is to describe the scope of the current literature on teamwork in home care nursing and outline needs for future research. Seven electronic databases were systematically searched and 798 articles were identified and screened. Seventy articles remained and were assessed for eligibility by two of the authors. Eight themes were identified among the 32 articles that met the inclusion criteria. Studies concerned with teamwork regarding isolated tasks/problems and specific teamwork characteristics were most common. Methods were predominantly qualitative. Multiple method approaches and ethnographic field studies were rare. Descriptions of the context were often lacking. The terms ‘team’ and ‘teamwork’ were inconsistently used and not always defined. However, it is apparent that teamwork is important and home care nurses play a crucial role in the team, acting as the link between professionals, the patient and their families. Future studies need to pay more attention to the context and be more explicit about how the terms team and teamwork are defined and used. More research is also needed regarding necessary team skills, effects of teamwork on the work environment and technology‐mediated teamwork.
of subsets in baricitinib-treated patients with an integrated analysis

Objective: Baricitinib is an oral selective inhibitor of Janus kinase (JAK) 1 and JAK2 that is efficacious in patients with rheumatoid arthritis (RA). This study analyzed changes in lymphocyte cell subsets during baricitinib treatment and correlated such changes with clinical outcomes of baricitinib treatment. Methods: An integrated analysis was conducted by pooling data from three completed Phase 3 trials comparing placebo and baricitinib treatment (RA-BEAM, RA-BUILD, and RA-BEACON) and one ongoing long-term extension study (RA-BEYOND) in patients (N=2,186) with active RA. Results: Baricitinib treatment was associated with an early transient increase in total lymphocyte count at week 4, which returned to baseline by week 12. Up to week 104, transient changes within normal reference ranges in T cells and subsets were observed with baricitinib treatment. B cells and relevant subpopulations increased after 4 weeks of baricitinib treatment with no further increases noted through 104 weeks of treatment. for Conclusion: changes
for role of fluctuations and stress on the viscosity of cell aggregates,’’

Repeat proteins contain short, tandem arrays of simple structural motifs (20 (cid:1) 40 aa). These stack together to form nonglobular structures that are stabilized by short-range interactions from residues close in primary sequence. Unlike globular proteins, they have few, if any, long-range nonlocal stabilizing interactions. One ubiquitous repeat is the tetratricopeptide motif (TPR), a 34-aa helix-turn-helix motif. In this article we describe the folding kinetics of a series of 7 designed TPR proteins that are assembled from arraying identical designed consensus repeats (CTPRa n ). These range from the smallest 2-repeat protein to a large 10-repeat protein ( (cid:1) 350 aa). In particular, we describe how the energy landscape changes with the addition of repeat units. The data reveal that although the CTPRa proteins have low local frustration, their highly symmetric, modular native structure is reﬂected in their multistate kinetics of unfolding and folding. Moreover, although the initial folding of all CTPRa n proteins involves a nucleus with similar solvent accessibility, their subsequent folding to the native structure depends directly on repeat number. This corresponds to an increasingly complex landscape that culminates in CTPRa10 populating a misfolded, off-pathway intermediate. These results extend our current understanding of the malleable folding pathways of repeat proteins and highlight the consequences of adding identical repeats to the energy landscape. Kinetics
Methodology for service life prediction of window frames

Window frames are an important element of buildings, with an enormous impact on the thermal performance and interior comfort conditions of buildings. Knowledge regarding the service life of window frames is extremely relevant, aiding the adoption of adequate solutions in the design and maintenance stages. This study proposes a methodology for the service life prediction of window frames, based on the visual inspection of 182 case studies, in-use conditions, in which the degradation phenomena and various characteristics of window frames are surveyed. This information is converted into degradation curves, which express the evolution of the degradation of window frames over time, allowing their service life to be estimated, as well as the influence of their characteristics on their durability. For aluminum and wooden frameworks, estimated service lives of 37.6 and 27.3 years are obtained. These results reveal that the window exposure conditions and the users’ behaviors have a substantial impact on the degradation of window frames.
Edinburgh Explorer Clinic variation in glycaemic control for children with Type 1 diabetes in England and Wales

Aims: To determine the scope for improving children’s glycaemic outcomes by reducing variation between clinics and examine the role of insulin regimen and clinic characteristics. Methods : Cross-sectional analysis of 2012-13 National Paediatric Diabetes Audit data from 21,773 children <19 years with Type 1 diabetes cared for at 176 clinics organised into 11 regional diabetes networks in England and Wales. Variation in glycated haemoglobin (HbA 1c ) was explored by multilevel models with a random effect for clinic. The impact of clinic context was quantified by computing the % of total variation in HbA 1c which occurs between clinics -Intraclass Correlation Coefficient (ICC). Results : Overall, 69 of the 176 diabetes clinics (39%) had a glycaemic performance which differed significantly from the national average after adjusting for patient case-mix with respect to age, gender, diabetes duration, deprivation and ethnicity. However, differences between clinics accounted for 4.7% of the total variation in HbA 1c. Inclusion of within-clinic HbA 1c standard deviation led to a substantial reduction in ICC to 2.4%. Insulin regimen, clinic volume, and diabetes networks had a small or moderate impact on ICC. Conclusions : Differences between diabetes clinics accounted for only a small portion of the total variation in glycaemic control. This implies that national glycaemic improvements might best be achieved not only by targeting poor centres but also by shifting the whole distribution of clinics to higher levels of quality.
Research on the Energy Efficiency Indicators of Transport Diesel Engines under Transient Operation Conditions

In this study, we have investigated the efficiency of transport diesel engines CAT3512B-HD in transient braking and acceleration modes in 2M62M locomotives. A comparative analysis of the diesel engine performance has been performed at speeds of power increase and braking ranging from 4–5 kW/s to 17–18 kW/s. A decrease in the fuel economy occurred, and the main reason for it (compared with the steady-state operating condition at qcycl = idem) has been found to be the deterioration of the mechanical efficiency coefficient due to the loss of the additional equipment kinetic energy of the engine. The efficiency decreased by 3–3.5% under power increase operations and by 10–14% in the braking modes. The original methodology for the evaluation of the diesel engine parameters registered by the engine control units (ECU) in the engine operating conditions, mathematical modelling application AVL BOOST, and analytical summaries in artificial neural networks (ANNs) have been used. The errors in the obtained results have been 5–8% at a determination coefficient of 0.97–0.99.
Class I MHC Molecule Protein in Association with an Allogeneic Clone to Multiple Peptides from the Same CTL + Potent Cytolytic Response by a CD8

CTL clone 2C recognizes the allogeneic class I MHC molecule L d in association with peptides derived from a -ketoglutarate dehydrogenase (oxoglutarate dehydrogenase (OGDH)), a ubiquitous intracellular protein. One of these peptides, QLSPFPFDL (QL9), elicits more vigorous cytolytic responses than two previously identiﬁed naturally processed peptides with overlapping sequences, LSPFPFDL (p2Ca) and VAITRIEQLSPFPFDL (p2Cb), from OGDH. In this study, we show that QL9 forms a more stable complex with cell surface L d than does p2Ca or p2Cb and is processed from the longer, naturally occurring peptide p2Cb by 20S proteosomes in vitro. The N-terminal cyclized pyroglutaminyl QL9 (pyroQL9), a form of QL9 to which it is converted at the low pH used for peptide isolation from tissue extracts, is even more active than QL9 in cytotoxicity assays with 2C CTL. Overall, the results indicate that along with the abundant natural peptides p2Ca and p2Cb, the QL9 and other OGDH peptides of various lengths, sharing a conserved C-terminal sequence, are also processed and presented with L d as allogeneic ligands for T cells expressing 2C TCR. All these peptides, each available in a low amount, could act in concert at the cell surface, resulting in a high density of cognate ligands that accounts for the exceptionally potent cytolytic response by 2C CTL. The Journal of Immunology, 2001, 166: 3028–3034.
D e g r ee of A g r e e m e nt in P l a s ma g F u n i o n al a ne

The purpose of this study was to assess the interchangeability of the nephelometric (immunoassay), von Clauss, and optical (derived) fibrinogen assays. When the nephelometric assay was compared with either of the two functional assays (199 samples) and when the von Clauss and optical methods were compared (879 samples), Pearson and intraclass correlations were . 96 to . 97. However, there were statistically significant biases (P < .001); the mean ratios of nephelometric to functional assay values were 1.05 to 1.07, and the mean optical to von Clauss assay ratio was 1.05 (data analyzed as logs and expressed as antilogs). The 95% limits Fibrinogen is a glycoprotein of 340,000 d and is syn thesized in both megakaryocytes and hepatocytes. 1 It has an electrophoretic mobility in the (J 2 globulin region and functions primarily as a coagulation fac tor, an acute-phase reactant secondary to inflamma tory processes or tissue injury, or as a marker for con sumptive of plasma acute of agreement demonstrated that 5% of the ratios for the von Clauss and optical methods were outside the 0.83 to 1.32 range. Analyses restricted to cases with a fibrinogen value of less than 2.0 g/L resulted in somewhat greater biases and higher upper lim its of agreement. Laboratorians need more than correlations to make informed judgments regarding the interchangeability of these methods. 1997;107:527-533.
Do mega-mergers create value?

Existing literature shows that mega-M&A deals valued over $500mil end up destroying the shareholder value of acquirers on a significant scale. Our paper considers mega-deal as a dependent event and examines the role of acquirer’s previous acquisition experience playing in the outcome of mega-deals. We find that mega-deals conducted by firms with a high level of acquisition experience, i.e. a firm completed at least 12 transactions before, are more likely to be completed. In addition, more experienced acquirer of mega-deals generate positive abnormal stock returns for shareholders in both short-run and long-run, with a dollar value gain of $50.6 million around deal announcement. We also find that more experienced acquirers are better at managing the post-acquisition integration process and enjoy a significant improvement in operating performance. This table reports calendar time abnormal returns over three event windows. The table presents the equal-weight and value-weight analysis results. CTAR12 , CTAR24 and CTAR36 respectively represent long-run returns for the samples over 12-, 24-, and 36-month period following the announcement date. First, we present the values for the full sample. Next, we sub-divide our sample based on the level of acquisition experience. Significance at the 1%, 5% and 10% levels is denoted by ***, ** and * respectively.
J C A P 0 1 ( 2 0 1 0 ) 0 0 5 ournal of C osmology and A stroparticle P hysics

We estimate the contribution of Galactic pulsars, both ordinary and millisecond pulsars (MSPs), to the high-energy (>100 MeV) γ−ray background. We pay particular attention to the high-latitude part of the background that could be confused with an extragalactic component in existing analyses that subtract a Galactic cosmic-ray model. Our pulsar population models are calibrated to the results of large-scale radio surveys and we employ a simple empirical γ−ray luminosity calibration to the spin-down rate that provides a good fit to existing data. We find that while ordinary pulsars are expected to contribute only a fraction ∼ 10−3 of the high-latitude γ−ray intensity (IX ∼ 1 × 10−5 ph s−1 cm−2 sr−1), MSPs could provide a much larger contribution and even potentially overproduce it, depending on the model parameters. We explore these dependences using a range of MSP models as a guide to how γ−ray measurements can usefully constrain the MSP population. Existing γ−ray background measurements and source counts already rule out several models. Finally, we show how fluctuations in the γ−ray sky can be used to distinguish between different sources of the background.
and attribution of Perfectionism, Achievement Motives, and Attribution of Success and Failure in Female Soccer Players

While some researchers have identified adaptive perfectionism as a key characteristic to achieving elite performance in sport, others see perfectionism as a maladaptive characteristic that undermines, rather than helps athletic performance. Arguing that perfectionism in sport contains both adaptive and maladaptive facets, the present article presents a study of N = 74 female soccer players investigating how two facets of perfectionism—perfectionis-tic strivings and negative reactions to imperfection (Stoeber, Otto, Pescheck, Becker, & Stoll, 2007)—are related to achievement motives and attributions of success and failure. Results show that striving for perfection was related to hope of success and self-serving attributions (internal attribution of success). Moreover, once overlap between the two facets of perfectionism was controlled for, striving for perfection was inversely related to fear of failure and self-depreciating attributions (internal attribution of failure). In contrast, negative reactions to imperfection were positively related to fear of failure and self-depreciating attributions (external attribution of success) and inversely related to self-serving attributions (internal attribution of success and external attribution of failure). It is concluded that striving for perfection in sport is associated with an adaptive pattern of positive motivational orientations and self-serving attributions of success and failure, which may help athletic performance. In contrast, negative reactions to imperfection are associated with a maladaptive pattern of negative motivational orientations and self-depreciating attributions, which is likely to undermine athletic performance. Consequently, perfectionism in sport may be adaptive in those athletes who strive for perfection, but can control their negative reactions when performance is less than perfect.