Miracle-dz/UniFAR-FTUs huggingface dataset:
Confusion-Based Metric Learning for Regularizing Zero-Shot Image Retrieval and Clustering

Deep metric learning turns to be attractive in zero-shot image retrieval and clustering (ZSRC) task in which a good embedding/metric is requested such that the unseen classes can be distinguished well. Most existing works deem this “good” embedding just to be the discriminative one and race to devise the powerful metric objectives or the hard-sample mining strategies for learning discriminative deep metrics. However, in this article, we first emphasize that the generalization ability is also a core ingredient of this “good” metric and it largely affects the metric performance in zero-shot settings as a matter of fact. Then, we propose the confusion-based metric learning (CML) framework to explicitly optimize a robust metric. It is mainly achieved by introducing two interesting regularization terms, i.e., the energy confusion (EC) and diversity confusion (DC) terms. These terms daringly break away from the traditional deep metric learning idea of designing discriminative objectives and instead seek to “confuse” the learned model. These two confusion terms focus on local and global feature distribution confusions, respectively. We train these confusion terms together with the conventional deep metric objective in an adversarial manner. Although it seems weird to “confuse” the model learning, we show that our CML indeed serves as an efficient regularization framework for deep metric learning and it is applicable to various conventional metric methods. This article empirically and experimentally demonstrates the importance of learning an embedding/metric with good generalization, achieving the state-of-the-art performances on the popular CUB, CARS, Stanford Online Products, and In-Shop datasets for ZSRC tasks.
Autoimmune Pulmonary Alveolar Proteinosis during the Treatment of Idiopathic Inflammatory Myopathy

Approximately 50% of idiopathic inflammatory myopathies (IIMs) are associated with interstitial lung disease (ILD). Typically, IIM-ILD manifests as nonspecific interstitial pneumonia. We herein report a rare case of a 78-year-old man with autoimmune pulmonary alveolar proteinosis (PAP) that developed during IIM treatment. The diagnosis of autoimmune PAP was based on detecting anti-granulocyte-macrophage colony-stimulating factor antibodies. We postulated that PAP may have been induced by IIM treatment with prednisolone. Our case suggests that the possibility of autoimmune PAP should be considered in patients with lung lesions during the clinical course of IIM.
Miscarriage, SUDI and Neonatal death: exploring paramedic experience and practice

This paper aims to provide an exploratory investigation into paramedic experiences of attending cases of Miscarriage, Sudden and Unexpected Deaths of Infants (SUDI) and other forms of neonatal loss. It draws on a background literature review, but focuses primarily on exploring issues raised by paramedics during a structured discussion group on this topic. Existing literature highlights the ways in which baby and infant death is one of the most stressful and challenging areas of paramedic practice. Paramedics participating in our discussion group reinforced this issue identifying five key areas of concern: baby loss as a rare occurrence, resuscitation, lack of information concerning the post admissions process, professional closure, and support to parents. We conclude by arguing that further research in this area is needed, along with better support and guidelines to assist paramedics with a wide range of issues from resuscitation to bereavement support.
Did Age at Surgery Influence Outcome in Patients With Hirschsprung Disease? A Nationwide Cohort Study in the Netherlands

Objectives: Hirschsprung disease (HD) requires surgical resection of affected bowel, but the current evidence is inconclusive regarding the optimal age for resection. The aim of this study was to assess whether age at resection of the aganglionic segment is a determinant for surgical outcomes. Methods: A cross-sectional cohort study was done including all consecutive patients with HD between 1957 and 2015, aged 8 years or older (n = 830), who were treated in 1 of the 6 pediatric surgical centers in the Netherlands. Outcome measures were mortality, postoperative complications, stoma rate and redo surgery rate, retrieved from the medical records. Additionally, constipation and fecal incontinence rate in long term were assessed with the Defecation and Continence Questionnaire (DeFeC and P-DeFeC). Results: The medical records of 830 patients were reviewed, and 346 of the 619 eligible patients responded to the follow-up questionnaires (56%). There was a small increase in the risk of a permanent stoma [odds ratio (OR) 1.01 (95% confidence interval {CI}: 1.00–1.02); P = 0.019] and a temporary stoma [OR 1.01 (95% CI: 1.00–1.01); P = 0.022] with increasing age at surgery, regardless of the length of the aganglionic segment and operation technique. Both adjusted and unadjusted for operation technique, length of disease, and temporary stoma, age at surgery was not associated with the probability and the severity of constipation and fecal incontinence in long term. Conclusions: In this study, we found no evidence that the age at surgery influences surgical outcomes, thus no optimal timing for surgery for HD could be determined.
A community-based adapted exercise program to increase quality of life and self-efficacy among adults with physical disabilities: A mixed-method study

Background: Self-efficacy is one of the key constructs that directly influence physical activity, community participation, and mental health while acting as a strong influence on the quality of life (QOL) for adults with physical disabilities (AWPDs). There are relatively few studies focusing on a community-based exercise program in this population. Objective: This study aims to quantitatively examine a community-based adapted exercise program on the QOL and self-efficacy of AWPDs. In addition, we explored AWPD's perceived benefits of community-based exercise programming and any factors that may influence those perceived benefits. Method: Adults with physical disabilities (N = 50) participated in a 9-week community-based adapted exercise program (90-minute session, twice per week). QOL (WHOQOL-BREF) and self-efficacy were measured at baseline and at the conclusion of the program. A follow-up focus group (n = 22) was conducted at the postprogram. Quantitative data were analyzed by paired t test (α = 0.05). Qualitative data were analyzed by thematic coding and content analysis. Result: Significant improvement with moderate effect size was found across all variables. Two main themes emerged from the qualitative analysis: 1) perceived benefit of exercise program and 2) factors of an exercise program for AWPD. Conclusion: A community-based exercise program and self-efficacy play a large role in the exercise behaviors and QOL of AWPDs. The benefits of exercise and factors identified as promoting exercise may be carefully considered to improve QOL for this population. The finding of this study offers practical recommendations to community-based exercise specialists, which would assist in establishing an appropriate exercise program for AWPDs.
The impact of COVID 19 on the outcomes of thrombectomy in stroke patients: A systematic review and meta‐analysis

We aimed to conduct the current meta‐analysis to provide better insight into the efficacy of mechanical thrombectomy (MT) in managing COVID‐19 patients suffering from a stroke. An electronic search was conducted through eight databases for collecting the current evidence about the efficacy of MT in stroke patients with COVID‐19 until 18 December 2021. The results were reported as the pooled prevalence rates and the odds ratios (ORs), with their corresponding 95% confidence intervals (CI). Out of 648 records, we included nine studies. The prevalence of stroke patients with COVID‐19 who received MT treatment was with TICI ≥2b 79% (95%CI: 73–85), symptomatic intracranial haemorrhage 6% (95%CI: 3–11), parenchymal haematoma type 1, 11.1% (95%CI: 5–23), and mortality 29% (95%CI: 24–35). On further comparison of MT procedure between stroke patients with COVID 19 to those without COVID‐19, we found no significant difference in terms of TICI ≥2b score (OR: 0.85; 95%CI: 0.03–23; p = 0.9). However, we found that stroke patients with COVID‐19 had a significantly higher mortality rate than stroke patients without COVID‐19 after MT procedure (OR: 2.99; 95%CI: 2.01–4.45; p < 0.001). Stroke patients with COVID‐19 can be safely and effectively treated with MT, with comparable reperfusion and complication rates to those without the disease.
Bifactor Modelling, Reliability, and Validity of the Material Values Scale in Chinese Youth

The present study validated the bifactor model of the Material Values Scale (MVS) and examined the association between materialism and subjective well-being (SWB). Study 1 utilized a material values questionnaire that 1673 college students completed. Confirmatory factor analysis results indicated that the bifactor model of the MVS had a better fit than other models. Likewise, the findings were replicated in Study 2 using a larger sample size (N = 2627). Through structural equation modeling, only the general and specific factors of success were found to be negative predictors of SWB. Our study both provides a methodological reference for measuring the MVS and compensates for the limitations of MVS measurement results.
Mislocalization after inhibition of saccadic adaptation

Saccadic eye movements are often imprecise and result in an error between expected and actual retinal target location after the saccade. Repeated experience of this error produces changes in saccade amplitude to reduce the error and concomitant changes in apparent visual location. We investigated the relationship between these two plastic processes in a series of experiments. Following a recent paradigm of inhibition of saccadic adaptation, in which participants are instructed to look at the initial target position and to continue to look at that position even if the target were to move again, our participants nevertheless perceived a visual probe presented near the saccade target to be shifted in direction of the target error. The location percept of the target gradually shifted and diverged over time from the executed saccade. Our findings indicate that changes in perceived location can be the same even when changes in saccade amplitude differ according to instruction and can develop even when the amplitude of the saccades executed during the adaptation procedure does not change. There are two possible explanations for this divergence between the adaptation states of saccade amplitude and perceived location. Either the intrasaccadic target step might trigger updating of the association between pre- and post-saccadic target positions, causing the localization shift, or the saccade motor command adjusts together with the perceived location at a common adaptation site, downstream from which voluntary control is exerted upon the executed eye movement only.
Do all infants with congenital hearing loss meet the 1-3-6 criteria? A study of a 10-year cohort from a universal newborn hearing screening programme in Singapore

Abstract Objective To evaluate 1) the outcomes of a local universal newborn hearing screening (UNHS) programme and its audiological follow-ups at 3- and 6-month points, 2) the education outcomes of children with congenital hearing loss (CHL). Design Retrospective study that analysed data containing hearing screening, diagnosis, intervention and schooling information from electronic databases. Study sample Children aged 5 to 15 years old who were born between 2004–2014 and underwent UNHS in a local hospital. Results Over a 10-year cohort, 99.4% of 29,972 newborns underwent UNHS; approximately 90% of them were screened by 1 month of age. However, only 10% of the cohort strictly fulfilled the 1-3-6 criteria recommended by the Joint Committee on Infant Hearing. Lost to follow-up (LTF) rate was highest at post-diagnosis (35%). 80% of infants who were intervened between 6 and 48 months of age went to mainstream schools. The remaining 20% had additional disabilities or family factors. Conclusions A high UNHS coverage rate may not translate to meeting the 1-3-6 criteria. Despite ease of access to our healthcare system, LTF at post-diagnosis remained high. In the absence of additional disabilities or family factors, infants intervened during the sensitive window could still potentially make it into mainstream schools.
A summary review of carcass cutability data comparing primal value of immunologically and physically castrated barrows

Abstract The objectives were to 1) assess cutability, quality, and value of carcasses from immunologically castrated (IC) barrows compared with carcasses from physically castrated (PC) barrows and 2) evaluate the effect of hot carcass weight (HCW) on cutability and value of IC barrows summarizing U.S. data. Lean cutting yield (LCY) was defined as: LCY = [(whole ham + trimmed loin + Boston butt + picnic + spareribs)/chilled side wt] x 100. Carcass cutting yield (CCY) was determined using the following equation: CCY = [(lean cutting yield components + natural fall belly)/chilled side wt] x 100. To evaluate the effects of HCW of IC barrows on carcass cutting yields, IC barrows were grouped by HCW: light ( < 90.9 kg), average (90.9–97.7 kg), or heavy ( > 97.7 kg). Differences in the value of the carcass components for IC and PC barrow carcasses were calculated using a 5 yr average of meat prices from the USDA Agriculture Marketing Service and the carcass cutting yield estimates generated from this summary. Data were analyzed using the MIXED procedure of SAS with fixed effects of Improvest treatment or HCW group. Study was included as a random effect. This review allowed for a summarization of the treatment averages of 851 IC and PC barrow carcasses. Lean cutting yield of IC barrows was 1.41 units greater (P < 0.0001) than PC barrows (70.97 vs. 69.56%). Similarly, CCY of IC barrows was 1.29 units greater (P < 0.001) compared with PC barrows (87.27 vs. 85.98%). As HCW of IC barrows increased, both CCY and LCY declined (P < 0.01), with light IC barrow carcasses having a 1.43 unit advantage in CCY compared with heavy IC barrow carcasses (P < 0.01). Natural fall bellies of PC barrows comprised a greater (P < 0.05) percentage of side weight than those from IC barrows (15.81 vs. 15.50%). A reduction in belly primal value was confirmed by a 3.43 unit reduction in the commercial bacon slicing yields of IC barrows. However, belly yield and slicing yield differences were minimized when IC barrows were marketed at a heavier weight. Using carcass cutout estimates determined in the summary as the foundation for value calculations, lean cuts of IC barrow carcasses were worth $2.66 to $3.80 more than PC barrow carcasses. Therefore, after adjustment for the reduction in belly primal value, the primal value of an IC barrow carcass was $2.08 to $3.13 greater than a PC barrow carcass.
The impact of COVID‐19 on nurse leadership characteristics

Abstract Background Nurse leaders are vital for improving nursing efficiencies and the quality of care that they provide during a crisis and its aftermath. The value of positive leadership characteristics has never been more critical than during the COVID‐19 pandemic. Functioning in a crisis mode required nurse leaders to demonstrate the necessary skills for clear communication and solid leadership. Therefore, nursing leadership, especially in emergencies such as the COVID‐19 pandemic, needs to be transformative in the sense that leaders are informational, motivating, and able to advance the organization, notwithstanding a global pandemic. Timely leadership research during and after COVID‐19 is crucial for filling the literature gap resulting from the unique changes in the nursing profession in the post‐pandemic period. Objective This study aimed to investigate leadership characteristics shown by nurse leaders during the COVID‐19 pandemic, and investigate nurses' perceptions of nurse leader effectiveness based on leaders' work roles. Methods An exploratory, quantitative study was conducted 18 months after the declaration of the COVID‐19 pandemic (June–August 2021). The Multifactor Leadership Questionnaire (MLQ 5X) was sent to registered nurses (RNs) in Texas using the State Board's listing of active RNs. In total, 70 practicing RNs participated in the study. Data were analyzed using descriptive statistics and multivariate correlational analysis. Results Perceived leadership characteristics remained primarily transformational. Nurse directors and executives reported positive leadership characteristics more frequently than did staff and charge nurses. Linking Evidence to Action Specific tactics and strategies must be adopted to support nurses and nursing leadership during ongoing healthcare challenges. Close monitoring of leadership characteristics will enable organizations to support and provide educational opportunities for ongoing organizational success.
Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration and tail‐docking

Abstract This study performed population‐pharmacokinetic/pharmacodynamic (pop‐PK/PD) modeling of ketoprofen and flunixin in piglets undergoing routine castration and tail‐docking, utilizing previously published data. Six‐day‐old male piglets (8/group) received either ketoprofen (3.0 mg/kg) or flunixin (2.2 mg/kg) intramuscularly. Two hours post‐dose, piglets were castrated and tail docked. Inhibitory indirect response models were developed utilizing plasma cortisol or interstitial fluid prostaglandin E2 (PGE2) concentration data. Plasma IC50 for ketoprofen utilizing PGE2 as a biomarker was 1.2 μg/ml, and ED50 for was 5.83 mg/kg. The ED50 calculated using cortisol was 4.36 mg/kg; however, the IC50 was high, at 2.56 μg/ml. A large degree of inter‐individual variability (124.08%) was also associated with the cortisol IC50 following ketoprofen administration. IC50 for flunixin utilizing cortisol as a biomarker was 0.06 μg/ml, and ED50 was 0.51 mg/kg. The results show that the currently marketed doses of ketoprofen (3.0 mg/kg) and flunixin (2.2 mg/kg) correspond to drug responses of 33.97% (ketoprofen‐PGE2), 40.75% (ketoprofen‐cortisol), and 81.05% (flunixin‐cortisol) of the maximal possible responses. Given this information, flunixin may be the best NSAID to use in mitigating castration and tail‐docking pain at the current label dose.
Determination of spider mite abundance in soil of field-grown cucumbers and in plants under predatory mite pressure in invasive infestations using HRM real-time PCR assay

The two spotted spider mite, Tetranychus urticae Koch L. (Acari: Tetranychidae), is a plant pest that can lead to severe economic losses in open field cucumber cultivation. Between 2017 and 2019 we studied the abundance of spider mites in the soil to estimate the potential infestation pressure of soil colonizing spider mites. The spider mites were heterogeneously distributed in small concentrations in the soil. Soil colonizing spider mites did not affect spider mite abundance on plants and reversed. We observed that spider mite migration occurred primarily from the edge of the field adjacent to the weed strip. In 2020 and 2021, we investigated the efficacy of the predatory mite Neoseiulus californicus (McGregor) for suppressing spider mite hotspots in the cropland. We compared untreated spider mite hotspots with N. californicus treated hotspots and showed that a single release of predatory mites could result in a high level of control when spider mite infestation density was initially high. With this study, soil can be ruled out as a habitat for spider mites, and attention to spider mite pest control can be directed to plant infestations. The highly sensitive HRM real-time PCR assay was used for the quantification of the spider mites.
Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques

There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS.
Beyond E-FAST scan in trauma: Diagnosing of traumatic diaphragmatic rupture with bedside ultrasound

Traumatic diaphragmatic rupture is relatively rare, and even more difficult to diagnose. Physical examination often fails to identify this injury, and basic investigation like chest x-ray can miss this half of the time. Although not part of standard FAST (focused assessment with sonography for trauma) ultrasound scan in trauma, bedside ultrasound has the potential to pick up this pathology. This case illustrates that ultrasound in trauma can go beyond standard E-FAST (extended FAST) protocol.
University of Birmingham Evaluating an intervention to increase cereal fiber intake in children

Background: Observational studies have shown that higher cereal fiber intake is associated with reduced type 2 diabetes risk. However, it remains uncertain whether this association is causal. Objective: Thisstudyevaluatedthefeasibilityofaninterventiontoincreasecerealfiberintakeinchildrenusingbreakfast cereals. Methods: The study was a 2-arm parallel group randomized controlled trial in 9–10-y-old children, who received free supplies of high-fiber breakfast cereals ( > 3.5 g/portion) or low-fiber breakfast cereals ( < 1.0 g/portion) to eat daily for 1 mo with behavioral support to promote adherence. Children provided baseline and 1-mo fasting blood samples, physical measurements, and 24-h dietary recalls. The primary outcome was the group difference in change in plasma total alkylresorcinol (AR) concentration; secondary outcomes were group differences in nutrient intakes and adiposity indices. Analyses (complete case and multiple imputation) were conducted by regressing the final AR concentration on baseline AR in models adjusted for sex, ethnicity, age, and school (random effect). Results: Two-hundred seventy-two children were randomly assigned (137 receiving a low-fiber and 135 a high-fiber diet) and 193 (71%) provided fasting blood samples at baseline and follow-up. Among randomized participants, median (IQR) of baseline AR was 43.1 (24.6–85.5) nmol/L and of cereal fiber intake was 4.5 (2.7–6.4) g; 87% of participants reported consuming the cereal on most or all days. Compared with changes in the low-fiber group, the high-fiber group had greater increases in AR (40.7 nmol/L; 95% CI: 21.7, 59.8 nmol/L, P < 0.0001) and in reported cereal fiber intake (2.9g/d; 95% CI: 2.0, 3.7 g; P < 0.0001). There were no appreciable differences in other secondary outcomes. Conclusions: We have developed a simple and acceptable nutritional intervention that increases markers of daily cereal fiber intake in children. This intervention could be used to test whether increases in cereal fiber intake in children might reduce insulin resistance. This trial was registered at www.isrctn. com as ISRCTN33260236. J Nutr 2021;151:379–386.