Miracle-dz/UniFAR-FTUs huggingface dataset:
DMD049197 291..295

UDP-glucuronosyltransferases (UGTs) catalyze phase II conjugation reactions and play an important role in the inactivation and elimination of several drugs. It is well known that the UGT activity in fetal livers is low compared with the UGT activity in adult livers. In this study the mRNA expression levels of the three human subfamilies, 2B7, 2B15, and 2B17, were determined in 20 adult and 60 fetal liver tissue specimens. The expression profile in fetal kidneys (N = 43), adrenals (N = 46), and lungs (N = 37) was also determined. All fetal and adult samples were genotyped for the UGT2B17 deletion polymorphism. Adult liver contained 13–36 times higher levels of UGT2B mRNAs as compared with fetal livers. UGT2B7 was most abundant in fetal lungs and kidneys, whereas UGT2B15 and UGT2B17 were predominant in the liver. There was a significant correlation between UGT2B7 expression levels in lungs and kidneys, whereas for the other UGT2Bs no correlation between the different tissues was observed. Fetuses expressing two UGT2B17 alleles (ins/ins) displayed significantly higher levels of UGT2B17 mRNA compared to ins/del fetuses in lungs, whereas in the other tissues no gene dose-effect was
ORIGINAL RESEARCH PAPER TO MEASURE LOWER BODY STRENGTH IN INDIAN POPULATION USING CHAIR STAND TEST

The thirty second chair stand test has been used as a measure of lower body fitness in older adults from 60 – 90 years, healthy or unhealthy. This study aims at establishing the reliability and validity of this technique as a measure of lower body strength in an Indian population in individuals of age groups 20 to 59 years. OBJECTIVES: To evaluate the thirty second chair stand test (CST) as a measure of lower body strength in an Indian population. METHODOLOGY: A prospective case study was done from June 2017 to June 2018 in the department of Physical medicine and rehabilitation in 100 subjects of the ages of 20 to 59 years. For the 30 – second CST, individuals were required to stand up from a standard chair to a fully extended standing position as many times as possible with their arms folded across their chest. The number of completed repetitions achieved in 30 seconds was recorded. Test retest reliability was evaluated by performing this test on two separate occasions 1 week apart. Intra – class variations was analyzed across age and gender. FINDINGS: Intraclass reliability R ranged from 0.98 to 0.99 – with a majority of values being 0.99 indicating that the tests have good relative reliability across trials. ANOVA results revealed no significant changes from scores from day 1 testing to day 2 retesting, thus indicating that the tests also have absolute reliability across trials. The scores were found to decline across age and are lower for older age group (40 – 59) as compared to younger (20-39). The scores were found to be lower for females as compared to males. CONCLUSIONS: The results of this study indicate that the THIRTY SECOND CHAIR STAND TEST is a reliable test to measure lower body strength. We assessed construct validity across age and gender and a positive trend was found. Hence it is a valid test.
Prevalence and Associated Factors of Metabolic Syndrome Among Patients with Severe Mental Illness at Hawassa, Southern-Ethiopia Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Dovepress

Background: Patients with severe mental disorders have a high risk of metabolic-related complications like metabolic syndrome (MetS), diabetes mellitus (DM), hypertension and lipid derangements, and these factors may predispose them to a high mortality rate. Data is very scarce regarding MetS among patients with severe mental illness in Ethiopia. Therefore, this study aimed to assess the prevalence of MetS and its associated factors among patients with severe mental illness. Methods: A cross-sectional study was conducted in Hawassa University Comprehensive Specialized Hospital from January to June 2019 among adult patients attending a psychiatric outpatient department, Southern Ethiopia. A systematic random sampling technique was used to select 245 study subjects. Socio-demographic and other data were collected using a structured questionnaire. Both the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Federation (IDF) guidelines were used to de ﬁ ne MetS. Results: The prevalence of MetS was 24.5% and 26.9% by NCEP-ATP and IDF criteria respectively. In both de ﬁ nitions, females had signi ﬁ cantly higher MetS when compared to males (31.4% vs 19.6%; p=0.03 by NCEP), and (34.3% vs 21.7%; p =0.03 by IDF), respectively. Duration >5 years with mental illness indicated higher MetS when compared to duration ≤ 5 years (42.9% vs 19.9%, p=0.001; and 46.9% vs 21.9%, p<0.0001) in NCEP and IDF, respectively. In addition, marital status [AOR (95% CI): 2.4 (1.1 – 5.3)], and BMI [AOR (95% CI): 8.4(4.0 – 17.6)], duration > 5 years with mental illness [AOR (95% CI): 2.8 (1.2 – 6.5)], and age >40 years [AOR (95% CI): 2.7(1.2 – 6.1)] were signi ﬁ cantly associated factors of MetS by NCEP. While BMI, age >40 years and duration > 5 years with mental illness were associated with MetS by IDF. Conclusion: Long-time experience with severe mental illness and antipsychotic therapy might predispose patients to metabolic complications with signi ﬁ cant risks of cardiovascular events. Therefore, intensive screening of patients for MetS/components is required during follow-up based on national non-communicable diseases guideline. Besides, the proper intervention of patients concerning lifestyle changes and averting risk full behaviors is mandatory.
NONLINEAR ELLIPTIC EQUATIONS WITH CONCENTRATING REACTION TERMS AT AN OSCILLATORY BOUNDARY

In this paper we analyze the asymptotic behavior of a family of solutions of a semilinear elliptic equation, with homogeneous Neumann boundary condition, posed in a two-dimensional oscillating region with reaction terms concentrated in a neighborhood of the oscillatory boundary θε ⊂ Ωε ⊂ R2 when a small parameter ε > 0 goes to zero. Our main result is concerned with the upper and lower semicontinuity of the set of solutions in H1. We show that the solutions of our perturbed equation can be approximated with one defined in a fixed limit domain, which also captures the effects of reaction terms that take place in the original problem as a flux condition on the boundary of the limit domain.
OPTH_A_276120 2667..2677

1Carolina Eyecare Physicians, LLC, Mt. Pleasant, SC, USA; 2Science in Vision, Bend, OR, USA Purpose: To evaluate the vision, defocus curve, reading speed and patient satisfaction after implantation of an extended depth of focus (EDOF) IOL in one eye and a diffractive multifocal in the fellow eye. Setting: One clinical practice in the USA. Design: Prospective unmasked non-randomized clinical trial. Methods: Subjects presenting for routine cataract surgery interested in reducing their dependence on spectacles were enrolled. Study endpoints included uncorrected and distancecorrected binocular distance (4 m), intermediate (66 cm) and near (40 cm) visual acuity at 3 months. Additional endpoints included the residual refraction, spectacle independence, overall satisfaction with vision, visual symptoms, reading speed and defocus curve. Results: With a best distance correction, 77% (30/39) of subjects had 20/25 or better VA at distance, intermediate and near and nearly all subjects had 20/32 or better VA at all three distances. Defocus curve results showed mean continuous vision of 20/25 or better from plano to −2.50 D. Nearly 80% (31/39) of subjects had 20/25 visual acuity from 0.00 D to −2.50 D. The critical print size was between 0.3 and 0.4 logMAR (20/40 to 20/50 Snellen Equivalent). Spectacle independence was 100% at distance, 95% at intermediate and approximately 70% at near. The percentage of subjects who were “not at all” or “slightly” bothered by visual disturbances ranged from 64% (16/25) for Halos to 88% (22/25) for Starbursts. Conclusions: EDOF/bifocal IOL blended implantation results in at least 20/25 mean visual acuity from distance to near with good spectacle independence and low reports of severe visual disturbances.
: Defining the Platform to Illustrate Value Creation , Routledge, 2022

Stakeholders and regulators have long been calling for changes to the way firms approach corporate reporting. Concerns that information contained in financial statements alone does not meet users’ needs have brought narrative commentary centre stage (Michelon et al., 2020). Empirical evidence confirms non-financial information is taking an increasingly integral role in firm disclosure strategies (Dyer et al., 2017; El-Haj et al., 2020) while providing substantial and varied insight into performance, risk, and environmental, social and governance (ESG) matters among others. More recently, attention is turning to the role of business models (BM) in narrative reporting. Essentially, a BM is a snapshot of how a business creates and maintains value (Amit and Zott, 2001). Understanding how a business generates value is of key importance to investors and other stakeholders, not least to provide a contextualising framework through which to understand firms’ financial and non-financial information (NFI). This has led to recent regulatory developments in the European Union, South Africa, and the UK, requiring firms to disclose their BM in annual reports. Despite interest by regulators and stakeholders, the role of BM in corporate reporting is an underexplored area in academic research.
for the temperature dependence of interactions.

Changing temperature can substantially shift ecological communities by altering the strength and stability of trophic interactions. Because many ecological rates are constrained by temperature, new approaches are required to understand how simultaneous changes in multiple rates alter the relative performance of species and their trophic interactions. We develop an energetic approach to identify the relationship between biomass ﬂuxes and standing biomass across trophic levels. Our approach links ecological rates and trophic dynamics to measure temperature-dependent changes to the strength of trophic interactions and determine how these changes alter food web stability. It accomplishes this by using biomass as a common energetic currency and isolating three temperature-dependent processes that are common to all consumer – resource interactions: biomass accumulation of the resource, resource consumption and consumer mortality. Using this framework, we clarify when and how temperature alters consumer to resource biomass ratios, equilibrium resilience, consumer variability, extinction risk and transient vs. equilibrium dynamics. Finally, we characterise key asymmetries in species responses to temperature that produce these distinct dynamic behaviours and identify when they are likely to emerge. Overall, our framework provides a mechanistic and more uniﬁed understanding of the temperature dependence of trophic dynamics in terms of ecological rates, biomass ratios and stability.
Assessing the Relevance of Phonemic Awareness Activities in Foreign Language Teaching and Learning

Phonemic awareness (PA) has been used primarily used to investigate children early reading comprehension and pronunciation skills and later on extended to second and foreign language vis-à-vis learners reading comprehension and pronunciation enhancement. Similarly, the current study uses PA activities based on J.F Lee and B. VanPatten (2003) structured input activities model as an effective way to raise learners’ awareness of the English phonemes exposed to them in order to attend to them by efficiently identifying, representing, and manipulating them. The participants involved in this study are first year students from the Department of Anglophone studies who speak Moore as first language, French as intermediate language, and English as foreign language. Having difficulties identifying, representing, and manipulating English phonemes, this study aims at helping them via structured PA activities. Using the Mann Whitney Wilcoxon Test as a statistical treatment, the findings of this study prove the effectiveness of PA activities since the group that benefited from the intervention outperformed the control group that received no treatment with a P-value less than 0.05 as 0.0001<0.5. In this logic the median of the PA group is higher than the control group: 14.5>10 though it was approximatively the same before the treatment. Also, the Likert’s scales approach which is further used to correlate students’ reactions to the results of the experiment proves that almost all students appreciate the PA activities as relevant and beneficial. Therefore, structured PA activities should be recommended in foreign language teaching when phonology is involved (244 words).
OTT_A_258332 6565..6572

1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, People’s Republic of China; 2Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA; 3Department of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, People’s Republic of China; 4Sid Faithfull Brain Cancer Research Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; 5Department of Clinical Epidemiology and Evidence-based Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, People’s Republic of China; 6Beijing Key Laboratory of Cancer Therapeutic Vaccines, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, People’s Republic of China; 7Gruber Laboratory, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA Purpose: The present study aimed to investigate the prognostic effect of PD-L1 expressing
Digital Technology in a Smart Tourist Destination: The Case of Porto

ABSTRACT Given that information and communication technologies (ICT) have become increasingly integrated into the tourism industry, this article aims to emphasize the growing importance of ICT for smart tourism destinations. As a city, Porto has been consolidating its position as a smart tourism destination by emphasizing tourists’ experiences that are evaluated through innovation, communication, and interactivity with tourists/visitors. A survey of 423 tourists visiting the city provided the data for this study. The analysis focuses on the availability of ICT in Porto and its influence on tourists’ decisions to visit the city. This information helps to determine whether the application and information available on the Internet had positively contributed to tourists’ satisfaction in their visits to Porto. In particular, this article focuses on the influence of ICT accessibility on tourists’ choices of destination, their experiences, and their satisfaction. The results obtained can serve as insights for others to understand how tourists’ behavior and experiences, their planning stages and their demand for information are affected by the availability of ICT, in the context of smart tourism destinations.
Conservation, Economics, and Management of Hunting on Private Land: An International, National and California Analysis By Luke Thomas Macaulay A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy

As the pace of habitat loss accelerates worldwide, private land use is increasingly important in conservation policy. A wide body of literature has discussed the potential conservation incentives that wildlife-associated recreation (hunting, fishing, and wildlifewatching) could provide on private lands, yet we lack a good baseline of the spending and landuse characteristics of wildlife-associated recreation from which to evaluate its significance. This analysis pools three nationwide surveys conducted over an 11-year period to analyze spending to access private land for hunting, fishing, and wildlife-watching in the U.S. and to evaluate that spending in the context of private land conservation and land-use policy. Results show that approximately 440 million acres of private land, an estimated 22% of the contiguous land area of the U.S. and 33% of all private land in the U.S., are either leased or owned for wildlifeassociated recreation. Much of these lands are private rangelands and forestlands. Land utilized for hunting accounted for 81% of that total, while land utilized for fishing and wildlife-watching, although comparatively small, likely includes riparian zones and areas with high environmental or amenity values. Hunters own or lease properties of larger size classes than anglers or wildlifewatchers, providing a possible economic incentive for maintaining large unfragmented properties that provide a variety of conservation benefits. Results show that Americans annually spend an estimated $814 million in day-use fees, $1.48 billion for long-term leases, and $14.8 billion to own private land primarily for wildlife-associated recreation. These findings underscore the influence of recreational users on the land use of vast areas of private land in the U.S. Current policy measures such as use-tax policies and incentive programs for hunting can be enhanced and expanded in order to reap additional conservation benefits on these lands.
Cloning and Characterization of the Endogenous Cephalosporinase Gene , cepA , from Bacteroides fragilis Reveals a New Subgroup of Ambler Class A ,-Lactamases

Bacteroides frgigli& CS30 is a clinical isolate resistant to high concentrations of benzylpenicillin and cephaloridine but not to cephamycin or penem antibiotics. fl-Lactam resistance is mediated by a chromosomally encoded cephalosporinase produced at a high level. The gene encoding this 13-lactamase was cloned from genomic libraries constructed in Escherichia coli and then mated with B. fragilis 638 for identification of ampicillin-resistant (Apr) strains. Apr transconjugants contained a nitrocefin-reactive protein with the physical and enzymatic properties of the original CS30 isolate. The (3-lactamase gene (cepA) was localized by deletion analysis and subcloned, and its nucleotide sequence was determined. The 903-bp cepA open reading frame encoded a 300-amino-acid precursor protein (predicted molecular mass, 34,070 Da). A 13-lactamase-deficient mutant strain of B. fiugilis 638 was constructed by insertional inactivation with the cepA gene of CS30, demonstrating strict functional homology between these chromosomal 13-lactamase genes. An extensive comparison of the CepA protein sequence by alignment with other 13-lactamases revealed the strict conservation of at least four elements common to Ambler class A. A further comparison of the CepA protein sequence with protein sequences of (-lactamases from two other Bacteroides species indicated that they constitute their own distinct subgroup of class A 13-lactamases.
Hutcheon, Ian and Shevalier, Maurice and Durocher, Kyle and Bloch, John and Johnson, Gareth and Nightingale, Michael and Mayer, Bernhard (2016) Interactions of CO2 with formation waters, oil and minerals and CO2 storage at the Weyburn

The Weyburn oil field in Saskatchewan, Canada, is hosted in Mississippian carbonates and has been subject to injection of CO2 since 2000. A detailed mineralogy study was completed as the basis for modeling of mineral storage of injected CO2. Combining the mineralogy with kinetic reaction path models and water chemistry allows estimates of mineral storage of CO2 over 50 years of injection. These results, combined with estimates of pore volume, solubility of CO2 in oil and saline formation waters, and the initial and final pore volume saturation with respect to oil, saline water and gas/supercritical fluid allow an estimate of CO2 stored in saline water, oil and minerals over 50 years of CO2 injection. Most injected CO2 is stored in oil (6.5•10 6 to 1.3•10 tonnes), followed closely by storage in supercritical CO2 (7.2•10 6 tonnes) with saline formation water (1.5 2•10 tonnes) and mineral storage (2 6•10 tonnes) being the smallest sinks. If the mineral dawsonite forms, as modeling suggests, the majority of CO2 dissolved in oil and saline formation water will be redistributed into minerals over a period of approximately 5000 years. The composition of produced fluids from a baseline sampling program, when compared to produced fluids taken three years after injection commenced, suggest that dawsonite is increasingly stable as pH decreases due to CO2 injection. The results suggest that hydrocarbon reservoirs that contain low gravity oil and little or no initial gas saturation prior to CO2 injection, may store the majority of injected CO2 solubilized in oil, making such reservoirs the preferred targets for combined enhanced oil recovery-CO2 storage projects.
DETERMINING THE IMPACT OF TAXPAYER PERCEPTIONS ON THE RATE OF USING ELECTRONIC FISCAL DEVICES AMONG SMALL BUSINESSES IN TANZANIA

This study determined the impact of taxpayer perceptions, in the form of the fear of punishment by the Tanzanian Revenue and Government authorities, on the rate of using Electronic Fiscal Devices (EFDs) among small business owners in Tanzania. As a result, the study sample was refined to include 279 small business owners, who are based in Arusha region. The key objectives of the study were to determine the categorical relationship between demographic characteristics and the fear of punishment, as well as to determine the impact of the fear of punishment on the rate of using EFDs. The study used the quantitative approach in addressing the objectives by employing the chi-square, ANOVA and ordinal regression as analytical techniques. Results of the analysis suggested no significant categorical relationship exists between demographic variables (the age, gender, and level of education) and the fear of punishment. Furthermore, the fear of punishment does not impact the rate of EFD use. The study recommends that the Tanzania Revenue Authority should not use age, gender, and level of education to determine the effectiveness of punishment among small business owners. Furthermore, the Tanzania Revenue Authority should not use intimidations as a method to impact compliance.