Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Short and Long Hyperglycemia on Cardioprotection by Remote Ischemic Preconditioning—A Translational Approach

The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented over the past years of research. In the clinical setting, the relationship between blood glucose and mortality appears linear, with amplifying risk associated with increasing blood glucose levels. Further, this seems to be independent of a diagnosis of diabetes. In the experimental setting, various comorbidities seem to impact ischemic and pharmacological conditioning strategies, protecting the heart against ischemia and reperfusion injury. In this translational experimental approach from bedside to bench, we set out to determine whether acute and/or prolonged hyperglycemia have an influence on the protective effect of transferred human RIPC-plasma and, therefore, might obstruct translation into the clinical setting. Control and RIPC plasma of young healthy men were transferred to isolated hearts of young male Wistar rats in vitro. Plasma was administered before global ischemia under either short hyperglycemic (HGs Con, HGs RIPC) conditions, prolonged hyperglycemia (HGl Con, HGl RIPC), or under normoglycemia (Con, RIPC). Infarct sizes were determined by TTC staining. Control hearts showed an infarct size of 55 ± 7%. Preconditioning with transferred RIPC plasma under normoglycemia significantly reduced infarct size to 25 ± 4% (p < 0.05 vs. Con). Under acute hyperglycemia, control hearts showed an infarct size of 63 ± 5%. Applying RIPC plasma under short hyperglycemic conditions led to a significant infarct size reduction of 41 ± 4% (p < 0.05 vs. HGs Con). However, the cardioprotective effect of RIPC plasma under normoglycemia was significantly stronger compared with acute hyperglycemic conditions (RIPC vs. HGs RIPC; p < 0.05). Prolonged hyperglycemia (HGl RIPC) completely abolished the cardioprotective effect of RIPC plasma (infarct size 60 ± 7%; p < 0.05 vs. HGl Con; HGl Con 59 ± 5%).
Prevalence and Antibiotic Susceptibility of Proteus mirabilis Isolated from Clinical Specimens in the Zainoel Abidin General Hospital, Banda Aceh, Indonesia

BACKGROUND: Proteus mirabilis is Gram-negative bacteria from the Enterobacteriaceae family causing various infections. AIM: This study aimed to determine the prevalence and distribution of Proteus mirabilis isolated from clinical specimens based on patients’ age, gender, type of specimen, and patient wards and their antibiotic sensitivity. METHODS: This study involved isolating, identifying, and testing antibiotic susceptibility to Proteus mirabilis isolates recoverred from clinical specimens of dr. Zainoel Abidin general hospital Banda Aceh during March 2020-March 2022. RESULTS: This study showed that 121 isolates of Proteus mirabilis were obtained from clinical specimens during the study with prevalence of almost 2%. Proteus mirabilis distribution based on the specimen type was most predominantly found in pus specimens and from patients in the the operating room and post surgery ward accounting for 84.29% and 35.53%. Proteus mirabilis was detected most frequently in individuals aged 46-55 years old (30.57 %), whereas it was found more frequently in men (71%) based on gender. The susceptibility of Proteus mirabilis to antibiotics was highest to cefoperazone, piperacillin/tazobactam, and amikacin reaching reaching 97.5%, 97.5, and 96.66%, respectively. CONCLUSION: The distribution of Proteus mirabilis isolates predominantly in pus specimens indicating its association with wound infections. Despite some antibiotics remain effective, implementation of the regular surveillance programs along with rational use of antibiotics may prevent the bacterial pathogen to spread particularly within healthcare settings.
Points at Rational Distances on a Parabola

This paper deals with the open problem of ﬁnding the maximum number of points on the parabola y = x 2 such that all of their mutual distances are rational. We obtain, in parametric terms, a set of seven points on this parabola such that four of the points have all of their six mutual distances rational, ﬁve of the points have all but one of their 10 mutual distances rational, six of the points have 12 mutual distances rational and the seven points have 15 of their mutual distances rational. By giving suitable numerical values to the parameters, we can obtain inﬁnitely many examples of seven points in which the ﬁrst four points, with all of their six mutual distances rational, have positive abscissae and are non-concyclic. Further, for any arbitrary positive integer n , we obtain in parametric terms the abscissae of n + 1 pairs of points on the given parabola such that 5 n +1 of their mutual distances are rational. With a suitable choice of parameters, we get numerical examples with 5 n +2 of the mutual distances rational.
Recorded audio feedback: bridging the chasm between educator and student in online assessment

Provision of detailed and constructive feedback on written assessments is a challenge in many contexts. Increasing instructor workloads due to growth in class sizes further complicates having personalised feedback to student achievements. This paper reports using recorded audio feedback on written assessments and evaluating student perceptions of this feedback using a mixed methods approach. Students receiving recorded audio feedback were surveyed and their perceptions towards the feedback they received further probed via semi-structured interviews. Survey numerical data indicate that students found the feedback convenient and easy to access, clear and easy to understand and more personal than written feedback. Survey open responses and interview responses were thematically analysed and identified major themes and subthemes that supported and further explained the numerical data. This study helps describe student perceptions to recorded audio feedback, which may be a useful tool for helping connect instructors and their students in different learning environments.
The splitting lemmas for nonsmooth functionals on Hilbert spaces II. The case at infinity

We generalize the Bartsch-Li's splitting lemma at infinity for $C^2$-functionals in [2] and some later variants of it to a class of continuously directional differentiable functionals on Hilbert spaces. Different from the previous flow methods our proof is to combine the ideas of the Morse-Palais lemma due to Duc-Hung-Khai [9] with some techniques from [11], [17], [18]. A simple application is also presented.
Pulse formation in phase-modulated optical fiber signals due to stimulated Brillouin scattering

The formation of sharp pulses from phase-modulated optical-fiber-guided cw signals in the presence of stimulated Brillouin scattering is studied. Analysis and computer simulations show how the peak amplitude of the pulses (i) increases with increasing magnitude of the phase shifts and (ii) decreases with increasing rise time of the phase shifts. The possibility of converting phase-modulated cw signals into pedestal-free pulses is also discussed.
Running-Induced Metabolic and Physiological Responses Using New Zealand Blackcurrant Extract in a Male Ultra-Endurance Runner: A Case Study

Physical training for ultra-endurance running provides physiological adaptations for exercise-induced substrate oxidation. We examined the effects of New Zealand blackcurrant (NZBC) extract on running-induced metabolic and physiological responses in a male amateur ultra-endurance runner (age: 40 years, body mass: 65.9 kg, BMI: 23.1 kg·m−2, body fat: 14.7%, V˙O2max: 55.3 mL·kg−1·min−1, resting heart rate: 45 beats·min−1, running history: 6 years, marathons: 20, ultra-marathons: 28, weekly training distance: ~80 km, weekly running time: ~9 h). Indirect calorimetry was used and heart rate recorded at 15 min intervals during 120 min of treadmill running (speed: 10.5 km·h−1, 58% V˙O2max) in an environmental chamber (temperature: ~26 °C, relative humidity: ~70%) at baseline and following 7 days intake of NZBC extract (210 mg of anthocyanins·day−1) with constant monitoring of core temperature. The male runner had unlimited access to water and consumed a 100-kcal energy gel at 40- and 80 min during the 120 min run. There were no differences (mean of 8, 15 min measurements) for minute ventilation, oxygen uptake, carbon dioxide production and core temperature. With NZBC extract, the respiratory exchange ratio was 0.02 units lower, carbohydrate oxidation was 11% lower and fat oxidation was 23% higher (control: 0.39 ± 0.08, NZBC extract: 0.48 ± 0.12 g·min−1, p < 0.01). Intake of the energy gel did not abolish the enhanced fat oxidation by NZBC extract. Seven days’ intake of New Zealand blackcurrant extract altered exercise-induced substrate oxidation in a male amateur ultra-endurance runner covering a half-marathon distance in 2 h. More studies are required to address whether intake of New Zealand blackcurrant extract provides a nutritional ergogenic effect for ultra-endurance athletes to enhance exercise performance.
Men’s career choices in early childhood education and care – an embodied intersectionality perspective

ABSTRACT The workforce in early childhood education and care (ECEC) is highly gender-segregated with a majority of women. Gender-sensitive professionalization is regarded a way to recruit more men, but there is a call for more empirical research into perspectives that combines bodily aspects of gender, professionalization and men`s career choices. Applying the notion of embodied intersectionality, this article analyses narrative data from Nordic men with varying experience with formal ECEC education and work. It explores how embodied and intersectional experiences of ECEC work and professionalism emerge in the narratives and how embodied and intersectional experiences link to the men’s choices of entering, staying, or leaving ECEC. Such experiences appear in the narratives related to entry to and exit from formal ECEC education to parental cooperation and to professional play practices. The findings are discussed in relation to the professionalization of ECEC, professional exclusionary and inclusionary mechanisms and debates about ECEC professionalization.
Laser anemometer measurements in a centrifugal compressor

The measurement of the flowfield in vaneless and vaned diffuser of high speed centrifugal compressor is reported in this paper. The flow measurement was carried out using a laser two focus velocimeter. The blade to blade distributions of absolute velocity and angle are compared with numerical distributions. The numerical results were obtained by using three-dimensional Navier-Stokes solver. The calculations are conducted on isolated impeller in steady approach.
Analysis of Time-Dependent Pharmacokinetics Using In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Modeling

SCR430, a sorafenib derivative, is an investigational drug exhibiting anti-tumor action. This study aimed to have a mechanistic understanding of SCR430’s time-dependent pharmacokinetics (TDPK) through an ex vivo study combined with an in vitro–in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) modeling. A non-compartmental pharmacokinetic analysis was performed after intravenous SCR430 administration in female Sprague-Dawley rats for a control group (no treatment), a vehicle group (vehicle only, 14 days, PO), and a repeated-dosing group (SCR430, 30 mg/kg/day, 14 days, PO). In addition, hepatic uptake and metabolism modulation were investigated using isolated hepatocytes from each group of rats. The minimal PBPK model based on IVIVE was constructed to explain SCR430’s TDPK. Repeated SCR430 administration decreased the systemic exposure by 4.4-fold, which was explained by increased hepatic clearance (4.7-fold). The ex vivo study using isolated hepatocytes from each group suggested that the increased hepatic uptake (9.4-fold), not the metabolic activity, contributes to the increased hepatic clearance. The minimal PBPK modeling based on an ex vivo study could explain the decreased plasma levels after the repeated doses. The current study demonstrates the TDPK after repeated dosing by hepatic uptake induction, not hepatic metabolism, as well as the effectiveness of an ex vivo approach combined with IVIVE and PBPK modeling to investigate the TDPK.
Regularite Des Solutions Du Probleme De Riemann

The smoothness of self–similiar solutions of the Riemann problem is studied. When the constant states are closed together, one gets uniqueness Resume:On e la regularite des solutions du probl`me de Riemann autosimilaire Dans cas de Donnees initials voisines, on obtient un resultat d'unicite.
Ring objects in the equivariant derived Satake category arising from Coulomb branches

This is the second companion paper of arXiv:1601.03586. We consider the morphism from the variety of triples introduced in arXiv:1601.03586 to the affine Grassmannian. The direct image of the dualizing complex is a ring object in the equivariant derived category on the affine Grassmannian (equivariant derived Satake category). We show that various constructions in arXiv:1601.03586 work for an arbitrary commutative ring object. The second purpose of this paper is to study Coulomb branches associated with star shaped quivers, which are expected to be conjectural Higgs branches of $3d$ Sicilian theories in type $A$ by arXiv:1007.0992.
Nonlinear elliptic equations with a singular perturbation on compact Lie groups and Homogeneous spaces

This paper is devoted to the study of a class of singular perturbation elliptic type problems on compact Lie groups or homogeneous spaces $\mathcal{M}$. By constructing a suitable Nash-Moser-type iteration scheme on compact Lie groups and homogeneous spaces, we overcome the clusters of "small divisor" problem, then the existence of solutions for nonlinear elliptic equations with a singular perturbation is established. Especially, if $\mathcal{M}$ is the standard torus $\textbf{T}^n$ or the spheres $\textbf{S}^n$, our result shows that there is a local uniqueness of spatially periodic solutions for nonlinear elliptic equations with a singular perturbation.
On Extension of Ginzburg-Jiang-Soudry Correspondence to Certain Automorphic Forms on $Sp_{4mn}(\BA)$ and $\wt{Sp}_{4mn \pm 2n}(\BA)$

Let $F$ be a number field, and $\BA=\BA_F$. In this paper, first, we provide a family of global Arthur parameters confirming all parts of a general conjecture on the relation between the structure of Fourier coefficients and the structure of global Arthur parameters, given by Jiang in 2012. Then we extend a correspondence between certain automorphic forms on $Sp_{4n}(\BA)$ and $\wt{Sp}_{2n}(\BA)$, given by Ginzburg, Jiang and Soudry in 2012, to certain automorphic forms on $Sp_{4mn}(\BA)$ and $\wt{Sp}_{4mn \pm 2n}(\BA)$, using the same idea of considering compositions of automorphic descent maps.
On geometric quantization of the Dirac magnetic monopole

We give a simple derivation of the spectrum of the Dirac magnetic monopole on a unit sphere S2 based on geometric quantization and the Frobenius reciprocity formula. The starting point is the calculation by Novikov and Schmelzer of the canonical symplectic structure on the coadjoint orbits of the isometry group of 3-dimensional Euclidean space E(3), which showed the appearance of the Dirac magnetic term.
A Multimodal Analysis of Physical Factors that Influence Adolescents’ Motor Competence

ABSTRACT This study analyzed the factorial structure of motor competence tests designed to evaluate motor development among adolescents, focusing on the two main dimensions of coordination and motor control. To this end, we randomly sampled 1,026 adolescents (45.3% males; 45.7% females, age 13.75 years, SD = 1.28). Participants completed the Multidimensional Sportcomp Motor Battery, which features ten motor competence tests. Results indicate that two factors grouped seven of the ten sub-tests related to upper body strength and skill related-fitness. The factorial structure remained stable across age and sex groups, with the exception of manual grip (grip strength) and 7 Meters with Feet Together (jumping) which may relate to a sex-specific evolutionary pattern for upper body force. The Flexibility, Equilibrium and Lateral Jumps tests were not grouped by this factor analysis on any established dimension. These results underscore the multidimensionality of physical factors that influence motor competence among adolescents.
Laver tables and combinatorics

The Laver tables are finite combinatorial objects with a simple elementary definition, which were introduced by R. Laver from considerations of logic and set theory. Although these objects exhibit some fascinating properties, they seem to have escaped notice from the combinatorics community. My aim is to give a short introduction to this topic, presenting the definition and main properties and stating a few open problems, which should arouse the interest of combinatorialists.
Regularisation effects of nonlinear semigroups

One introduces natural and simple methods to deduce $L^{s}$-$L^{\infty}$-re\-gularisation estimates for $1\le s< \infty$ of nonlinear semigroups holding uniformly for all time with sharp exponents from natural Gagliardo-Nirenberg inequalities. From $L^{q}$-$L^{r}$ Gagliardo-Nirenberg inequalities, $1\le q, r\le \infty$, one deduces $L^{q}$-$L^{r}$ estimates for the semigroup. New nonlinear interpolation techniques of independent interest are introduced in order to extrapolate such estimates to $L^{\tilde{q}}$-$L^{\infty}$ estimates for some $\tilde{q}$, $1\le \tilde{q}<\infty$. Finally one is able to extrapolate to $L^{s}$-$L^{\infty}$ estimates for $1\le s<q$. The theory developed in this monograph allows to work with minimal regularity assumptions on solutions of nonlinear parabolic boundary value problems as illustrated in a plethora of examples including nonlocal diffusion processes.
Consumer Behavior in Adopting Application-Based Transportation Services

With the rapid development and use of information technology in various fields, who can say that information technology is the main pillar that provides added value to society in the development process towards a developed nation? Moreover, information technology has entered all fields or sectors, especially transportation. One transportation service that takes advantage of the speed of access to information is the JAKET application-based transportation. The urgency of this study is to determine the level of acceptance of consumer technology in adopting JAKET application-based transportation services using the UTAUT 2 model approach. The sample used in this study was 120 respondents who used the JAKET application. The data collection process will be carried out from January to February 2021. The data collection used a survey with 33 question constructs, summarized in eight manifest variables. This study uses Structural Equation Modeling with a variance-based or component-based approach with Partial Least Square. This study's results indicate that performance expectancy, effort expectancy, hedonic motivation, and perceived risk significantly affect behavioral intention. Following that, there was no significant influence of social influence, facilitating conditions, or behavioral intention habits.
Expansion of SN 1993J

A sequence of images from very long baseline interferometry shows that the young radio supernova SN 1993J is expanding with circular symmetry. However, the circularly symmetric images show emission asymmetries. A scenario in which freely expanding supernova ejecta shock mostly isotropic circumstellar material is strongly favored. The sequence of images constitutes the first “movie” of a radio supernova.
Microbiota Community Structure and Interaction Networks within Dermacentor silvarum, Ixodes persulcatus, and Haemaphysalis concinna

Simple Summary Ticks pose a threat to humans and animals. However, microbial interactions on ticks are underappreciated. Complex microbial interactions shape microbial communities. There is limited information about microbial interactions on ticks, including Dermacentor silvarum, Ixodes persulcatus, and Haemaphysalis concinna. This study evaluated the microbial community composition of these three species and the microbial interactions based on pairwise interactions. The results reveal that the bacterial richness and microbiota structures of the three tick species are significantly different, and the bacterial richness of all ticks decreased significantly after they became engorged. A substantial expansion of the list of bacterial interactions was observed in ticks. Abstract Ticks carry and transmit a variety of pathogens, which are very harmful to humans and animals. To characterize the microbial interactions in ticks, we analysed the microbiota of the hard ticks, Dermacentor silvarum, Ixodes persulcatus, and Haemaphysalis concinna, using 16S rRNA, showing that microbial interactions are underappreciated in terms of shaping arthropod microbiomes. The results show that the bacterial richness and microbiota structures of these three tick species had significant differences. Interestingly, the bacterial richness (Chao1 index) of all ticks decreased significantly after they became engorged. All the operational taxonomic units (OTUs) were assigned to 26 phyla, 67 classes, 159 orders, 279 families, and 627 genera. Microbial interactions in D. silvarum demonstrated more connections than in I. persulcatus and H. concinna. Bacteria with a high abundance were not important families in microbial interactions. Positive interactions of Bacteroidaceae and F_Solibacteraceae Subgroup 3 with other bacterial families were detected in all nine groups of ticks. This study provides an overview of the microbiota structure and interactions of three tick species and improves our understanding of the role of the microbiota in tick physiology and vector capacity, thus being conducive to providing basic data for the prevention of ticks and tick-borne diseases.
Eimeria infection-related intestinal dynamics and microbiome, growth performance, and nutrient utilization in broiler chickens fed diets supplemented with multienzyme

Abstract Coccidiosis is an infectious parasitic disease. Increasing drug resistance and variable vaccine effectiveness have stimulated interests in developing alternate control strategies. Our research studied the effects of dietary supplementation of multienzyme (phytase, xylanase, β-glucanase, amylase, hemicellulase, and pectinase) in broiler chickens infected with coccidial pathogens by assessing (i) nutrient utilization, immunological response, and gut health-related indicators in small intestine; and (ii) intestinal microbiome modulations. One-day-old male Ross 708 chicks were assigned to 4 treatments in a 2 × 2 factorial arrangement comprising of 0 or 50 g·kg−1 multienzyme and oral challenge with phosphate buffer saline or mixed Eimeria spp. oocysts (250000 E. acervulina, 50000 E. maxima, and 50000 E. tenella). Multienzyme reduced (P < 0.05) Eimeria-induced loss in feed efficiency and nutrient utilization, partially explained by reduced decrease of b0,+ amino acid transporter in jejunum. Multienzyme suppressed (P < 0.05) the overexpression of interleukin-8 in duodenum and jejunum and ameliorated (P = 0.05) the decreased expression of antioxidant heme oxygenase 1 in ileum induced by Eimeria infection. Multienzyme facilitated (P < 0.01) the bloom of short-chain fatty acid-producing and fiber-degrading microbes. Multienzyme supplementation partly mitigated the adverse effects of Eimeria infection through multiple mechanisms: improving nutrient utilization, reducing local inflammation, and restoring microbial homeostasis.