Miracle-dz/UniFAR-FTUs huggingface dataset:
Bonobo social organization at the seasonal forest‐savanna ecotone of the Lomami national park

Examining the relationship between food and primate social organization helps us understand how the environment shaped hominin social evolution. However, there is debate as to whether the social differences between our two closest relatives, bonobos (Pan paniscus) and chimpanzees (Pan troglodytes), are due to differences in food availability between their respective habitats or to nonenvironmental factors. The most prominent theory is that bonobo communities have more socially cohesive, stable parties, centered on gregarious females because they evolved in food‐rich habitat where individuals, especially females, are less burdened by competition with groupmates. However, more research on bonobos in habitats with seasonal variation in food is needed. This study measured food availability and bonobo social organization at Luzaka, a new site in a seasonal forest fragment. Fruit abundance and dispersion were recorded for a year at Luzaka with the same methods used at Wamba, a bonobo site in more seasonally stable habitat and terrestrial herbaceous vegetation density was measured. At Luzaka, bonobo parties were also recorded for a year using camera traps. Fruit was more seasonal and dispersed at Luzaka than at Wamba. However, the social organization of Luzaka bonobos resembled social organization of bonobos at less seasonal sites. There were minor effects of fruit clumping on party size without effects on the proportion of females in parties suggesting that at Luzaka, the clumping of fruit slightly affected social cohesiveness but does not disproportionately affect females. Bonobo social cohesiveness and female gregariousness appears consistent and compatible with seasonal habitat.
The dusty, albeit ultraviolet bright, infancy of galaxies

The largest galaxies acquire their mass early on, when the Universe is still youthful. Cold streams violently feed these young galaxies a vast amount of fresh gas, resulting in very efficient star formation. Using a well resolved hydrodynamical simulation of galaxy formation, we demonstrate that these mammoth galaxies are already in place a couple of billion years after the big bang. Contrary to local star-forming galaxies, where dust re-emits a large part of the stellar ultraviolet (UV) light at infrared and sub-millimetre wavelengths, our self-consistent modelling of dust extinction predicts that a substantial fraction of UV photons should escape from primordial galaxies. Such a model allows us to compute reliably the number of high-redshift objects as a function of luminosity, and yields galaxies whose UV luminosities closely match those measured in the deepest observational surveys available. This agreement is remarkably good considering our admittedly still simple modelling of the interstellar medium physics. The luminosity functions of virtual UV luminous galaxies coincide with the existing data over the whole redshift range from 4 to 7, provided cosmological parameters are set to their currently favoured values. Despite their considerable emission at short wavelengths, we anticipate that the counterparts of the brightest UV galaxies will be detected by future sub-millimetre facilities like ALMA.
Reduced prescription of TNF-inhibitors in chronic arthritis based on therapeutic drug monitoring: A randomized controlled trial

Objective Dosing of tumour necrosis factor-α inhibitors (TNFis) is not personalized causing interindividual variation in serum drug levels; however, dose optimization is not widely implemented. We hypothesized that some patients are overdosed; thus, drug prescription could be reduced by therapeutic drug monitoring (TDM). Method Independent of disease activity, 239 adults treated for rheumatoid arthritis (n = 99), psoriatic arthritis 15 (n = 48), or spondyloarthritis (n = 92) were recruited for a 48-week prospective, randomized open-label trial. Standard care alone or plus TDM was applied in chronic arthritis patients treated with infliximab (IFX), (n = 81), etanercept (ETN) (n = 79), or adalimumab (ADA) (n = 79). Serum TNFi trough levels assessed at inclusion and every 4 months determined patients within/outside predefined therapeutic intervals, supporting change in prescription or drug switch. The primary endpoint was reduced drug prescription. Results Compared to standard care, TDM reduced prescribed IFX [−12% (95% confidence interval −20, −3); p = 0.001] and ETN (−15% (−29, 1); p = 0.01], and prolonged the interdosing intervals of ETN [+235% (38, 432); p = 0.02] and ADA [+28% (6, 51); p = 0.04]. Time to drug switch was accelerated (χ2 = 6.03, p = 0.01). No group differences in adverse events, disease activity, or self-reported outcomes were shown, indicating equally sustained remission. Conclusions TDM reduced prescription of IFX, ETN, and ADA and identified patients benefiting from accelerated drug switch, thereby minimizing treatment failure, risk of toxicity, and unnecessary adverse events.
A cluster of two psittacosis cases among women farmers exposed to Chlamydia psittaci‐infected domestic poultry in Zhejiang Province, China

A cluster of Chlamydia psittaci (C. psittaci) cases was reported in Zhejiang Province, China, 2019. This study evaluates the extent of the outbreak and determines the source of infection. Real‐time PCR and sequencing of the ompA gene of C. psittaci were performed to identify the cases, the domesticated poultry and close contacts. The index patient was a 76‐year‐old woman with chronic vertigo, and Case 2 was a 64‐year‐old female farmer with herpes zoster. Both women bought psittaci‐infected chickens or ducks from the same mobile street vendor and raised them for 10 days and 23 days before fever onset. There were no direct contact between the two women. C. psittaci test was positive for the two patients, one sick chicken, three healthy ducks and the vendor's chicken cage. Phylogenetic analysis showed that all seven C. psittaci positive samples carried identical ompA genotype A of C. psittaci. Of all of the patients' 148 close contacts, none tested positive for C. psittaci, or developed acute respiratory symptoms. Both patients were discharged after a 4‐week hospital stay. In conclusion, the source of this cluster was the poultry infected with C. psittaci, which occasionally cause infections in farmers, but inter‐human transmission seems unlikely.
Inhomogeneous percolation models for spreading phenomena in random graphs

Percolation theory has been used a great deal in the study of structural properties of complex networks such as the robustness, with remarkable results. Nevertheless, a purely topological description is not sufficient for a correct characterization of network behaviour in relation to physical flows and spreading phenomena taking place on them. The functionality of real networks also depends on the ability of the nodes and the edges to bear and handle loads of flows, energy, information and other physical quantities. We propose to study these properties, introducing a process of inhomogeneous percolation, in which both the nodes and the edges spread the flows out with a given probability. The generating functions approach is exploited in order to get a generalization of the Molloy–Reed criterion for inhomogeneous joint site–bond percolation in correlated random graphs. A series of simple assumptions allows the analysis of more realistic situations, for which a number of new results are presented. In particular, for the site percolation with inhomogeneous edge transmission, we obtain the explicit expressions for the percolation threshold for many interesting cases, which are analysed by means of simple examples and numerical simulations. Some possible applications are debated.
Characterization of Sphingobacterium sp. Ab3 Lipase and Its Coexpression with LEA Peptides

The mechanism of action of LEA proteins has remained unknown to many; in this study we reveal their presence and improved protein expression due to the molecular shielding effect reported by others. This paper should be regarded as a useful example of using such proteins to influence an existing expression system to produce difficult-to-express proteins. ABSTRACT Sphingobacterium sp. is a yellowish Gram-negative bacterium that is usually characterized by high concentrations of sphingophospholipids as lipid components. As microbial enzymes have been in high demand in industrial fields in the past few decades, this study hopes to provide significant information on lipase activities of Sphingobacterium sp. , since limited studies have been conducted on the Sphingobacterium sp. lipase. A microbe from one collected Artic soil sample, ARC4, was identified as psychrotolerant Sphingobacterium sp. , and it could grow in temperatures ranging from 0°C to 24°C. The expression of Sphingobacterium sp. lipase was successfully performed through an efficient approach of utilizing mutated group 3 late embryogenesis abundant (G3LEA) proteins developed from Polypedilum vanderplanki. Purified enzyme was characterized using a few parameters, such as temperature, pH, metal ion cofactors, organic solvents, and detergents. The expressed enzyme is reported to be cold adapted and has the capability to work efficiently under neutral pH (pH 5.0 to 7.0), cofactors like Na+ ion, and the water-like solvent methanol. Addition of nonionic detergents greatly enhanced the activity of purified enzyme. IMPORTANCE The mechanism of action of LEA proteins has remained unknown to many; in this study we reveal their presence and improved protein expression due to the molecular shielding effect reported by others. This paper should be regarded as a useful example of using such proteins to influence an existing expression system to produce difficult-to-express proteins.
A survey of antimicrobial-resistant Escherichia coli prevalence in wild mammals in Japan using antimicrobial-containing media

The emergence and spread of antimicrobial-resistant bacteria and resistance genes pose serious human and animal health concerns. Therefore, to control antimicrobial-resistant bacteria in the environment, the status of antimicrobial resistance of Escherichia coli in a variety of wild mammals and their prevalence were examined using antimicrobial-containing media. In total, 750 isolates were obtained from 274/366 (74.9%) wild mammals, and antimicrobial-resistant E. coli was detected in 37/750 isolates (4.9%) from 7 animal species (26/366 [7.1%] individuals). Using antimicrobial-containing media, 14 cefotaxime (CTX)- and 35 nalidixic acid-resistant isolates were obtained from 5 (1.4%) and 17 (4.6%) individuals, respectively. CTX-resistant isolates carried blaCTX-M-27, blaCTX-M-55, blaCTX-M-1, and blaCMY-2, with multiple resistance genes. Fluoroquinolone-resistant isolates had multiple mutations in the quinolone-resistance determining regions of gyrA and parC or qnrB19. Most resistant isolates exhibited resistance to multiple antimicrobials. The prevalence of antimicrobial-resistant bacteria observed in wild mammals was low; however, it is essential to elucidate the causative factors related to the low prevalence and transmission route of antimicrobial-resistant bacteria/resistance genes released from human activities to wild animals and prevent an increase in their frequency.
Frontoparietal Dysconnection in Covert Bipedal Activity for Enhancing the Performance of the Motor Preparation-Based Brain–Computer Interface

Motor-based brain-computer interfaces (BCIs) were developed from the brain signals during motor imagery (MI), motor preparation (MP), and motor execution (ME). Motor-based BCIs provide an active rehabilitation scheme for post-stroke patients. However, BCI based solely on MP was rarely investigated. Since MP is the precedence phase before MI or ME, MP-BCI could potentially detect brain commands at an earlier state. This study proposes a bipedal MP-BCI system, which is actuated by the reduction in frontoparietal connectivity strength. Three substudies, including bipedal classification, neurofeedback, and post-stroke analysis, were performed to validate the performance of our proposed model. In bipedal classification, functional connectivity was extracted by Pearson’s correlation model from electroencephalogram (EEG) signals recorded while the subjects were performing MP and MI. The binary classification of MP achieved short-lived peak accuracy of 73.73(±7.99)% around 200-400 ms post-cue. The peak accuracy was found synchronized to the MP-related potential and the decrement in frontoparietal connection strength. The connection strengths of the right frontal and left parietal lobes in the alpha range were found negatively correlated to the classification accuracy. In the subjective neurofeedback study, the majority of subjects reported that motor preparation instead of the motor imagery activated the frontoparietal dysconnection. Post-stroke study also showed that patients exhibit lower frontoparietal connections compared to healthy subjects during both MP and ME phases. These findings suggest that MP reduced alpha band functional frontoparietal connectivity and the EEG signatures of left and right foot MP could be discriminated more effectively during this phase. A neurofeedback paradigm based on the frontoparietal network could also be utilized to evaluate post-stroke rehabilitation training.
Establishment of a Cynomolgus Macaque Model of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Direct Inoculation of Adult T-Cell Leukemia Patient-Derived Cell Lines for HTLV-1 Infection

HTLV-1 was discovered in the 1980s as the causative agent of adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. However, the precise mechanisms leading to HTLV-1 chronic infection and the onset of the diseases still remain unidentified. ABSTRACT Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, the precise mechanisms leading to HTLV-1 chronic infection and the onset of the diseases have remained unclear, and effective vaccines for inhibiting the infection and the progression of pathogenesis have therefore not been developed. The use of a nonhuman primate (NHP) model is thought to be important for revealing the mechanisms of the progressive status and for the development of prevention procedures. In this study, we developed a cynomolgus macaque (CM) model of HTLV-1 infection by direct intravenous inoculation of HTLV-1-producing cells derived from ATL patients. The cell line used for infection, ATL-040, was selected as the most infectious one in our cell line library. CMs inoculated intravenously with 1 × 108 ATL-040 cells per animal became persistently infected with HTLV-1, as shown by the HTLV-1 provirus load (PVL) in peripheral blood mononuclear cells and HTLV-1-specific antibodies (2/2 animals). One CM inoculated intravenously with 1 × 107 ATL-040 cells did not have detectable PVLs despite the fact that anti-HTLV-1 antibodies were maintained for more than 2 years. Furthermore, immunological approaches, including CD8+ T cell depletion prior to infection (3/3 animals) and intrathecal inoculation (3/3 animals), led to increased proviral loads in the cynomolgus monkeys. The present method and the cynomolgus monkey model of HTLV-1 infection will be beneficial for immunological and virological studies on HTLV-1 aiming at the development of anti-HTLV-1 prophylactic vaccines and therapy drugs. IMPORTANCE HTLV-1 was discovered in the 1980s as the causative agent of adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. However, the precise mechanisms leading to HTLV-1 chronic infection and the onset of the diseases still remain unidentified. Thus, no effective vaccines to inhibit the infection and the progressive of pathogenesis have been developed. The use of appropriate animal models is essential for understanding HTLV-1 infection and pathogenesis. In order to establish a new nonhuman primate model for studies on HTLV-1 infection, cynomolgus monkeys were infected with HTLV-1 under a variety of experimental conditions. Our method, using a cell line generated from an ATL patient as a source of HTLV-1, was able to establish HTLV-1 infection in monkeys with a 100% success rate. This cynomolgus macaque model of HTLV-1 infection will contribute to the elucidation of HTLV-1 infection and its associated disease development.
Marginal proportional hazards models for clustered interval‐censored data with time‐dependent covariates

The Botswana Combination Prevention Project was a cluster‐randomized HIV prevention trial whose follow‐up period coincided with Botswana's national adoption of a universal test and treat strategy for HIV management. Of interest is whether, and to what extent, this change in policy modified the preventative effects of the study intervention. To address such questions, we adopt a stratified proportional hazards model for clustered interval‐censored data with time‐dependent covariates and develop a composite expectation maximization algorithm that facilitates estimation of model parameters without placing parametric assumptions on either the baseline hazard functions or the within‐cluster dependence structure. We show that the resulting estimators for the regression parameters are consistent and asymptotically normal. We also propose and provide theoretical justification for the use of the profile composite likelihood function to construct a robust sandwich estimator for the variance. We characterize the finite‐sample performance and robustness of these estimators through extensive simulation studies. Finally, we conclude by applying this stratified proportional hazards model to a re‐analysis of the Botswana Combination Prevention Project, with the national adoption of a universal test and treat strategy now modeled as a time‐dependent covariate.
Significant Tumor Reduction With Traditional Chinese Medicine in a Patient With Advanced Prostate Cancer: A Case Report

Prostate cancer (PC) is the most common malignancy of the male genitourinary system. For patients with advanced progressive PC, the treatment strategies include second-line endocrine therapy, chemotherapy, and immunotherapy. Such therapeutic techniques are either too expensive or too toxic for some patients, and traditional Chinese medicine (TCM) has become an alternative for its low cost and low toxicity. The application of Shi-pi-san and Gui-zhi-Fu-ling-wan in PC has never been reported. We report their application on a 71-year-old male patient, who was diagnosed with PC and was undergoing endocrine therapy. He originally chose chemotherapy, and experienced acute renal failure, which required hemodialysis during hospitalization. He felt weak and opted for Chinese herbal medicine treatment. After treatment with Shi-pi-san and Gui-zhi-Fu-ling-wan, the patient’s tumor and other symptoms were significantly reduced, and he reported feeling “refreshed. ” This case indicates that TCM treatment has unique advantages and is more tolerable than endocrine therapy and chemotherapy. Considering that the patient was undergoing hemodialysis treatment and using low-molecular-weight heparin (LMWH) to prevent blood coagulation while taking TCM, whether LMWH has a synergistic anticancer effect remains to be explored.
An Exponential Nonuniform Berry-Esseen Bound for Self-Normalized Sums

In this paper we shall derive exponential nonuniform Berry-Esseen bounds in the central limit theorem for self-normalized sums. We show that the size of the error can be reduced considerably by replacing the usual standardization by self-normalization. In particular, we establish the exponential bounds for the probability of the self-normalized sums under the condition that the third moment is finite, whereas an exponential moment assumption is required for the standardized sums. Applications to t-statistics and the probabilities of moderate deviations of self-normalized sums are also discussed.
On the desert between neutron star and black hole remnants.

The occurrence of a desert between neutron star (NS) and black hole (BH) remnants is reviewed. The dependence of stellar remnants on the zero age main sequence (ZAMS) progenitor mass for solar metallicity is taken from a recent investigation and further effort is devoted to NS and BH remnants. In particular, a density parameter is defined and related to NS mass and radius. Spinning BHs in Kerr metrics are considered as infinitely thin, homogeneous, rigidly rotating disks in Newtonian mechanics. Physical parameters for nonrotating (TOV) and equatorial breakup (EQB) configurations are taken or inferred from a recent investigation with regard to 4 NS and 3 quark star (QS) physically motivated equation of state (EOS) kinds. A comparison is performed with counterparts related to nonrotating and maximally rotating BHs. The results are also considered in the light of empirical relations present in literature. With regard to $J$-$M$ relation, EQB configurations are placed on a sequence of similar slope in comparison to maximally rotating BHs, but shifted downwards due to lower angular momentum by a factor of about 3.6. Under the assumption heavy baryons are NS constituents and instantaneously undergo quark-level reactions, the energy released (or adsorbed) is calculated using results from a recent investigation. Even if NSs exclusively host heavy baryons of the kind considered, the total amount cannot exceed about 10\% of the binding energy, which inhibits supernova explosions as in supramassive white dwarf (WD) remnants or implosions into BH. Alternative channels for submassive ($2<=M/m_\odot<=4$) BH formation are shortly discussed.
Manganese‐Enhanced Magnetic Resonance Imaging of the Heart

Manganese‐based contrast media were the first in vivo paramagnetic agents to be used in magnetic resonance imaging (MRI). The uniqueness of manganese lies in its biological function as a calcium channel analog, thus behaving as an intracellular contrast agent. Manganese ions are taken up by voltage‐gated calcium channels in viable tissues, such as the liver, pancreas, kidneys, and heart, in response to active calcium‐dependent cellular processes. Manganese‐enhanced magnetic resonance imaging (MEMRI) has therefore been used as a surrogate marker for cellular calcium handling and interest in its potential clinical applications has recently re‐emerged, especially in relation to assessing cellular viability and myocardial function. Calcium homeostasis is central to myocardial contraction and dysfunction of myocardial calcium handling is present in various cardiac pathologies. Recent studies have demonstrated that MEMRI can detect the presence of abnormal myocardial calcium handling in patients with myocardial infarction, providing clear demarcation between the infarcted and viable myocardium. Furthermore, it can provide more subtle assessments of abnormal myocardial calcium handling in patients with cardiomyopathies and being excluded from areas of nonviable cardiomyocytes and severe fibrosis. As such, MEMRI offers exciting potential to improve cardiac diagnoses and provide a noninvasive measure of myocardial function and contractility. This could be an invaluable tool for the assessment of both ischemic and nonischemic cardiomyopathies as well as providing a measure of functional myocardial recovery, an accurate prediction of disease progression and a method of monitoring treatment response.