Miracle-dz/UniFAR-FTUs huggingface dataset:
DMSO_A_238483 1643..1652

Zohreh Esfandiar Firoozeh Hosseini-Esfahani 1 Parvin Mirmiran Emad Yuzbashian Fereidoun Azizi 2 1Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Purpose: The current study aimed to investigate the relationship between daily consumption of total polyphenol and its subclasses and the incidence of diabetes. Materials and Methods: Eligible adults (n=6,547) were chosen from among participants of the Tehran Lipid and Glucose Study (TLGS) with an average follow-up of 3.0±1.6 years. Dietary intakes were evaluated using a valid and reliable semi-quantitative food frequency questionnaire. Biochemical variables and anthropometrics were evaluated at baseline and follow-up examinations. Multivariate Cox proportional hazard regression models were used to estimate the development of type 2 diabetes mellitus (T2DM) in relation to total intake of polyphenol and its subclasses (flavonoids, phenolic acids, stilbenes, and lignans). Results: This study was conducted on 2,882 men and 3,665 women, aged 41.3±14.6 and 39.0±13.4 years, respectively. The number of participants with the new-onset T2DM was 253. Mean intake of total polyphenol was 346±245 mg/1000 kcal. Risk of type 2 diabetes decreased from quartiles 1 to 4 for total polyphenols (HR: 1.00, 0.37, 0.61, 0.50, Ptrend<0.01), phenolic acids (HR: 1.00, 0.57, 0.49, 0.45, Ptrend<0.01), and lignans (HR: 1.00, 0.67, 0.61, 0.60, Ptrend<0.01), whereas non-significant results were found for flavonoids and stilbenes. This study suggests an inverse association between total intake of polyphenols, phenolic acids, and lignin, and the risk of T2DM. Conclusion: These results emphasize the potential protective role of polyphenol rich food groups (especially fruits and vegetables) in the prevention of T2DM.
Inflammatory markers and clinical factors which affecting the survival in metastatic renal cell carcinoma

Renal cell carcinoma (RCC) is an aggressive malignancy with a 40% recurrence risk after nephrectomy for localized tumor, with a 5-year survival rate below 20% in advanced stage. Today, despite the increase in early detection of small renal masses, up to 20% of the patients with RCC apply to health centers in the metastatic phase (1). In clinical studies with tyrosine kinase inhibitors (TKI) such as sunitinib, pazopanib, sorafenib; prolonged progressionfree survival (PFS) and overall survival (OS) have been obtained in patients with metastatic renal cell carcinoma (mRCC). New prognostic and predictive markers are needed for these agents that cause significant changes in mRCC management (2). The relationship between cancer development and inflammation has increased interest in the prognostic significance of inflammatory markers (3). The neutrophil-to-lymphocyte ratio (NLR), an index formed by dividing absolute neutrophil count into absolute lymphocyte count, is an inflammatory marker that has attracted researchers' attention due to its potential prognostic effect and has been identified as an independent prognostic factor in many types of cancer (4,5). Although a relationship between increased NLR and poor prognosis was demonstrated in patients with RCC (6); data on its role in patients with mRCC treated with sunitinib or pazopanib are insufficient. The Prognostic Nutritional Index (PNI), which is calculated using serum albumin concentration and total lymphocyte count in peripheral blood, was first used to obtain an idea about the immune nutritional status and surgical risk in patients undergoing gastrointestinal surgery (7). However, it was found that preop nutritional and immunological status was not only associated with postoperative complications but also associated with prognosis in malignancy patients, and currently PNI is used prognostically in various types of cancer (8-10). However, the prognostic role of PNI in mRCC patients using tyrosine kinase inhibitors has not been fully established. In this study, we aimed to evaluate the effects of NLR and PNI and also clinicopathological factors on progression-free Abstract
The Roles of Social Comparison Orientation and Regulatory Focus in College Students’ Responses to Fitspiration Posts on Social Media: Cross-sectional Study

Background Information shared via social media influences college students’ self-perceptions and behavior, particularly, “fitspiration” posts (ie, images of healthy food, people exercising, or fitness quotations). There are mixed findings regarding the mental health implications of fitspiration and its potential to motivate healthy behavior. Individual differences such as social comparison orientation and regulatory focus could aid in determining for whom fitspiration may be helpful versus harmful, though these characteristics have received limited attention in terms of students’ fitspiration perceptions. Objective This cross-sectional study examined associations between students’ fitspiration use (ie, intentional versus unintentional exposure while using social media), response tendencies (ie, feelings about the self and motivation to be physically active), social comparison orientation, and regulatory focus. Methods College students (N=344; 239/344, 69.5% women) completed an electronic survey in which they self-reported demographic information, the frequency of their social media use, exposure to fitspiration posts, typical feelings in response to fitspiration posts, and typical motivation for physical activity after viewing fitspiration posts. They also completed validated self-report measures of social comparison orientation and regulatory focus. Results College students reported frequent exposure to fitspiration posts on social media and that they experienced negative feelings in response to these posts more often than positive feelings. Average motivation for physical activity was rated as feeling motivated “some of the time. ” However, students who reported more negative feelings after viewing fitspiration also reported greater motivation to be physically active after exposure. Associations between the frequency of intentional fitspiration use and motivation for physical activity after viewing fitspiration posts were moderated by social comparison orientation (b=−0.01, P=.03) but not by regulatory focus (b=−0.002, P=.67). Conclusions Negative feelings about the self may be motivating for students with weak social comparison orientation, as fitspiration may highlight a discrepancy between one’s real and ideal self that does not prompt dejection or disengagement. However, negative feelings for prevention-focused students might not be as motivating because there are no salient negative models to avoid. Further research into these associations is warranted and could inform future efforts to promote student health and well-being during college.
A re-evaluation of wetland carbon sink concepts and measurements: A diagenetic solution down sediments

Aquatic canopy ecosystems ability to mitigate greenhouse gases (GHG) is currently based on the rate of sedimentary organic carbon accumulation (CA) and the protection of vulnerable stocks from remineralisation. However, remineralisation of allochthonous inputs constrains CA as sequestration, assessments neglect remineralisation over climatic scales, and often fail to account for recalcitrant material. The article clarifies the meaning of stock and sequestration as mitigation services through their net ecosystem production (NEP) and addresses the concerns through a series of hypothetical evolving ecosystems. A diagenetic solution is proposed that accounts for continuous remineralisation of CA and the remineralised fraction of labile allochthonous inputs to estimate the NEP. The solution was applied and tested for a seagrass and mangrove ecosystem. Uncorrected and corrected average CA was greater than the cal. NEP values by a factor of two for the seagrass and 30 for the mangrove. Nevertheless, the NEP values fell within reported ranges i.e., 27.6 g C m-2 yr-1 (mangrove) and 7.2 g C m-2 yr-1 (seagrass). The overestimate was largely maintained after including vulnerable stocks in the total carbon accreditation calculus. However, with the inclusion of CA, the total average carbon mitigation rates converged to 1 124 (seagrass) and 1 783 g C m-2 yr-1 (mangroves), when argued, in some circumstances, as a vulnerable stock concept after hindcasting to their original time of annual deposition. Mitigation concepts and measurements require re-evaluation and will assure that carbon credits are not overvalued, which would otherwise permit GHG emissions above the capacity of the ecosystem.
Antifungal Combinations in Dermatophytes

Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing antifungal agents against this group of fungi make the combinatorial approach particularly interesting to be investigated. Therefore, we reviewed the scientific literature concerning the antifungal combinations against dermatophytes. A literature search on the subject performed in PubMed yielded 68 publications: 37 articles referring to in vitro studies and 31 articles referring to case reports or clinical studies. In vitro studies involved over 400 clinical isolates of dermatophytes (69% Trichophyton spp., 29% Microsporum spp., and 2% Epidermophyton floccosum). Combinations included two antifungal agents or an antifungal agent plus another chemical compound including plant extracts or essential oils, calcineurin inhibitors, peptides, disinfectant agents, and others. In general, drug combinations yielded variable results spanning from synergism to indifference. Antagonism was rarely seen. In over 700 patients with documented dermatophyte infections, an antifungal combination approach could be evaluated. The most frequent combination included a systemic antifungal agent administered orally (i.e., terbinafine, griseofulvin, or azole—mainly itraconazole) plus a topical medication (i.e., azole, terbinafine, ciclopirox, amorolfine) for several weeks. Clinical results indicate that association of antifungal agents is effective, and it might be useful to accelerate the clinical and microbiological healing of a superficial infection. Antifungal combinations in dermatophytes have gained considerable scientific interest over the years and, in consideration of the interesting results available so far, it is desirable to continue the research in this field.
The mediating role of writing attitude in the relationship between secondary school students’ attitudes towards Turkish course and reading attitudes

Students’ attitudes towards Turkish course along with their reading attitudes constitute a significant variable that affects their entire life. This study aims to develop a model about secondary school students’ attitudes towards Turkish course which is effective in their academic achievement. It is hypothesized in the study that the attitude towards Turkish course increases in students with positive reading attitudes with the mediation of their increased writing attitudes. The participants of the study consisted of 394 5th, 6th and 7th grade students (199 females and 195 males). The data was gathered through the Scale for attitude towards Turkish Course, Reading Attitude Scale, and Writing Attitude Scale. The findings revealed significant positive relationships between all the variables that were analyzed. The findings obtained from the mediation analysis have shown that writing attitude partially mediates the relationship between the attitude towards Turkish course and reading attitude. The findings of the research have been discussed in the context of the literature and recommendations for further studies have been made.
Sea-level variability and change along the Norwegian coast between 2003 and 2018 from satellite altimetry, tide gauges and hydrography

Abstract. Sea-level variations in coastal areas can differ significantly from those in the nearby open ocean. Monitoring coastal sea-level variations is therefore crucial to understand how climate variability can affect the densely populated coastal regions of the globe. In this paper, we study the sea-level variability along the coast of Norway by means of in situ records, satellite altimetry data, and a network of eight hydrographic stations over a period spanning 16 years (from 2003 to 2018). At first, we evaluate the performance of the ALES-reprocessed coastal altimetry dataset by comparing it with the sea-level anomaly from tide gauges over a range of timescales, which include the long-term trend, the annual cycle and the detrended and deseasoned sea level anomaly. We find that coastal altimetry outperforms conventional altimetry products at most locations along the Norwegian coast. We later take advantage of the coastal altimetry dataset to perform a sea level budget along the Norwegian coast. We find that the thermosteric and the halosteric signals give a comparable contribution to the sea-level trend along the Norwegian coast, except for three, non-adjacent hydrographic stations, where salinity variations affect the sea-level trend more than temperature variations. We also find that the sea-level annual cycle is more affected by variations in temperature than in salinity, and that both temperature and salinity give a comparable contribution to the detrended and deseasoned sea-level along the entire Norwegian coast.
Galactic cosmic ray modulation in the heliosphere based on muon telescopes and ion chambers data

We study the galactic cosmic ray modulation in the heliosphere based on muon telescopes and ion chambers data. We analyze the modulation parameters of galactic cosmic ray transport in the heliosphere retrieved from GCR anisotropy for solar cycles 18-23 and parts of 17 and 24, covering the period 1937-2018. It was found that the ratio  of mean free paths normal and parallel to mean interplanetary magnetic field B is polarity dependent at Earth orbit with higher values for periods around solar minima for positive polarity (A>0) than for negative (A<0). Timeline of ratio  for more than 7 decades, exhibits a slight ~11-year and dominant ~22-year variation and has a strongly polarity dependent character with the considerable enhancement in the minimum epoch of solar activity for A>0 magnetic polarity. Results will be confronted with current modulation theories. We examine the diffusion-convection implications and the solar cycle and solar magnetic polarity dependence of cosmic ray modulation for muon and ion chamber data.
On Optimally Aggregating Data when Estimating the Nonhomogeneous Poisson Process Rate Function

Authors are encouraged to submit new papers to INFORMS journals by means of a style file template, which includes the journal title. However, use of a template does not certify that the paper has been accepted for publication in the named journal. INFORMS journal templates are for the exclusive purpose of submitting to an INFORMS journal and should not be used to distribute the papers in print or online or to submit the papers to another publication.
MDER_A_241205 115..137

Priya Miranda 1 Christopher D Cox Michael Alexander Slav Danev Jonathan RT Lakey 1Department of Surgery and Biomedical Engineering, University of California Irvine, Irvine, California, USA; 2Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA; 3Medeia Inc, Santa Barbara, CA, USA Abstract: Attention deficit hyperactivity disorder (ADHD) is a chronic heritable developmental delay psychiatric disorder requiring chronic management, characterized by inattention, hyperactivity, hyperkinectivity and impulsivity. Subjective clinical evaluation still remains crucial in its diagnosis. Discussed are two key aspects in the “characterizing ADHD” and on the quest for objective “pathognomonic/endophenotypic diagnostic markers of ADHD”. The first aspect briefly revolves around issues related to identification of pathognomonic/endophenotypic diagnostic markers in ADHD. Issues discussed include changes in ADHD definition, remission/persistence and overlapping-symptoms cum sharedheritability with its co-morbid cross-border mental disorders. The second aspect discussed is neurobiological and EEG-based studies on ADHD. Given the neurobiological and temporal aspects of ADHD symptoms the electroencephalograph (EEG) like NeuralScan by Medeia appears as an appropriate tool. The EEGs appropriateness is further enhanced when coupled with suitable behavior/cognitive/motor/psychological tasks/paradigms yielding EEG-based markers like event-related-potential (ERPs like P3 amplitudes and latency), reaction time variability (RTV), Theta:Beta ratio (TBR) and sensorimotor rhythm (SMR). At present, these markers could potentially help in the neurobiological characterization of ADHD and either help in identifying or lay the groundwork for identifying pathognomonic and/or endophenotypic EEG-based markers enabling its diagnosis, treatment and management.
5-9 : mild anxiety 10-14 : moderate anxiety 15-21 : severe anxiety Symptom Checklist

Dr Archana Mishra, Dr Sheeba Marwah, Dr Nupur Anand Dr Dalimi Mushahary Associate Professor, VMMC and Safdarjung hospital, Ansari Nagar, New Delhi 110029, India Assistant Professor VMMC and Safdarjung hospital, Ansari Nagar, New Delhi 110029, India Senior Resident, VMMC and Safdarjung hospital, Ansari Nagar, New Delhi 110029, India Post Graduate Resident, VMMC and Safdarjung hospital, Ansari Nagar, New Delhi 110029, India
mRNA COVID-19 Vaccination and Development of CMR-confirmed Myopericarditis

Introduction: Several case reports or small series have suggested a possible link between mRNA COVID vaccines and the subsequent development of myocarditis and pericarditis. This study is a prospective collection and review of all cases with a myocarditis/pericarditis diagnosis over a 2-month period at an academic medical center. Methods: Prospective case series from 1st June 2021 until 31st July 2021. Patients were identified by admission and discharge diagnoses which included myocarditis or pericarditis. Inclusion criteria were: in receipt of mRNA vaccine within one month prior to presentation; The CMR protocol included cine imaging, native T1 and T2 mapping, late gadolinium enhancement and post contrast T1 mapping. All CMR studies were read in consensus by two experienced readers. Diagnosis was based on clinical presentation, ECG/echo findings and serial troponins and was confirmed in each case by CMR. Incidence was estimated from total doses of mRNA vaccine administered in the Ottawa region for the matching time-period. This data was obtained from the Public Health Agency of Ottawa. Results: 32 patients were identified over the period of interest. Eighteen patients were diagnosed with myocarditis; 12 with myopericarditis; and 2 with pericarditis alone. The median age was 33 years (18-65 years). The sex ratio was 2 females to 29 male. In 5 cases, symptoms developed after only a single dose of mRNA vaccine. In 27 patients, symptoms developed after their second dose of. Median time between vaccine dose and symptoms was 1.5 days (1-26 days). Chest pain was the commonest symptom, but many others were reported. Non-syncopal non-sustained ventricular tachycardia was seen in only a single case. Median LV ejection fraction (EF) was 57% (44-66%). Nine patients had an LVEF below the normal threshold of 55%. Incidence of myopericarditis overall was approximately 10 cases for every 10,000 innoculations. Summary and Conclusions: This is the largest series in the literature to clearly relate the temporal relationship between mRNA COVID vaccination, symptoms and CMR findings. In most patients, symptom onset began within the first few days after vaccination with corresponding abnormalities in biomarkers and on ECG. Cardiac MRI confirmed acute myocardial and pericardial changes with the presence of edema demonstrated with both tissue mapping and late gadolinium enhancement. Symptoms settled quickly with standard therapy and patients were discharged within a few days. No major adverse cardiac events and no significant arrhythmias were noted during inpatient stay. Further follow up will be required to ascertain the longer-term outcomes of this patient group.
The Effect of Job Design and Quality of Work Life Toward Affective Commitment of Teachers

The purpose of this study was to analyze the direct influence of job design and quality of work life on the affective commitment of teachers. This research method with a quantitative approach and data analysis techniques using path analysis. The findings of this study prove the direct effect of job design on affective, there is a positive direct effect quality of work life on affective commitment and there is a positive direct effect of job design on the quality of work life. The conclusion is that increasing the teacher's affective commitment must be supported by the job design and the quality of work life properly, effectively and efficiently.
Mechanically Robust Soft Bioelectronics: Towards Conductive Elastomers with a Low Percolation Threshold

Conductive polymer-elastomer composites have been proposed as an alternative to the metals conventionally used for bioelectronic devices. Being softer and more stretchable than metals such as platinum and gold, they can mitigate the adverse effects associated with mechanical mismatch and fatigue failure. Such composites are conventionally made by embedding conductive polymer (CP) particles inside an elastomeric matrix. However, to achieve such a structure, a high CP loading that reaches a percolation threshold is required. High percolation thresholds lead to the degradation of mechanical properties. This study presents an alternate approach designed to reduce CP content while maintaining conductivity through the matrix. A PEDOT:PSS composite was produced by filling a CP aerogel with polydimethylsiloxane (PDMS). This approach successfully formed a robust and conducting material, with only 1.8wt% CP. However, the composite displayed plastic deformation behaviour limiting electrical performance under strain. Potential improvements lie within modification of the PEDOT:PSS/PDMS interface.