Miracle-dz/UniFAR-FTUs huggingface dataset:
Academic Achievement in Science of Grade V Pupils with Integration of Video Clips

This study investigated the effects of video clips in the academic performance of public elementary school for the school year 2011-2012. The study was conducted to test the significant difference in the academic performance of public elementary pupils who were taught using conventional method of teaching with integration of video clips and those who were taught using conventional method of teaching without the integration of video clips instruction in science lessons. A quasi-experimental posttest design was used to conduct the study on 69 public elementary pupils of two intact classes. A validated researcher-made 30-item achievement test was used to measure the learning gained by both the experimental and the control group. The data were treated with mean, standard deviation and t-test for independent samples at 0.05 level of significance. It was found out that there is a significant difference in academic achievement public elementary pupils who were taught using conventional method of teaching with integration of video clips that had a very satisfactory academic performance compared to public elementary pupils who were taught in conventional method of teaching without integration of video clips. Therefore, integration of video clips in science lessons could enhance the academic achievement of the pupils.
The L-Chart for Non-Normal Processes

Abstract This paper presents a proposal to construct control charts for non-normal processes and an application. This control chart is based on the least-square L-estimator, which replaces the average and the standard deviation usually calculated for Shewhart charts. This estimator has a minimum variance for estimation of the process position and scattering whatever the data distribution. We focus our attention on “multi-generators” processes, like screw-machines or multi-die holder for injection molding, these processes are non-normally distributed.
An Agile Driven Architecture Modernization to a Model-Driven Development Solution An industrial experience

– This paper concerns model-driven development (MDD) used in time critical development. We present an agile MDD process developed in consideration of lean and agile development principles and we show its application to the evolutionary development of a real world application supplied to the banking sector. Our approach involves a novel use of concurrent reverse and forward engineering and through our industrial report we are able to provide strong support in favor of the claim that MDD and agile practices can be used together, preserving the benefits of each.
Less-Known Tourist Attraction Analysis Using Clustering Geo-tagged Photographs via X-means

—Today, travelers can readily travel around the world using convenient transportation. Not only are opportunities to go abroad for sightseeing is increasing, but tourism industries of every country are developing indirectly. Moreover, many travelers obtain the latest tourist information from the internet for their journeys. However, most information specifically relates to popular tourist attractions, leading to crowds flocking there, which make tourists feel uncomfortable. Contrary to existing studies, which specifically emphasize analyses of popular tourist attractions, we are striving to disperse crowds from popular tourist attractions and provide more spots for travelers to choose by discovering less-known tourist attractions. This study therefore specifically examines discovery of less-known Japanese tourist attractions under the assumption that these spots exist in unfamiliar cities of tourists. According to results of analyzing geo-tagged photographs on Flickr, we use the X-means algorithm to group Japanese cities into different clusters. X-means is an extension of K-means that improved the shortcomings of K-means and which greatly reduced the probability of being trapped into a local optimum. Furthermore, these clusters were used to survey unfamiliar clusters to Japanese and Taiwanese people. Thereby, we can eliminate spots that are in familiar clusters. We propose a formula for ranking tourist attractions that lets travelers choose these spots easily. Results of verification experiments demonstrated that some less-known tourist attractions appeal to Taiwanese and Japanese. Additionally, we examined some factors that might affect respondents as they decide whether a spot is attractive to them or not.
What can we Learn about Disease Etiology from Case-Case Analyses? Lessons from Breast Cancer 1

Copyright © 2010 American Association for Cancer Research What can we Learn about Disease Etiology from Case-Case Analyses? Lessons from Breast Cancer María Elena Martínez, Giovanna Cruz, Abenaa Brewster, Melissa Bondy, Patricia Thompson Authors’ Affiliations: Arizona Cancer Center, University of Arizona, Tucson, Arizona, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, University of Texas M.D. Anderson Cancer Center, Houston, Texas
Characterization of Macrolide Efﬂux Pump mef Subclasses Detected in Clinical Isolates of Streptococcus pyogenes Isolated between 1999 and 2005 (cid:1)

The macrolide efﬂux mechanism of resistance, mef , was characterized in community-acquired respiratory tract infections with Streptococcus pyogenes. Fifty-four (4.6%) M phenotype isolates were screen tested as negative for mef (A). Of these 54 isolates, 5 (0.4%), 27 (2.3%), and 1 (0.1%) were considered to be mef (I) positive, a novel mosaic variant of mef , or a novel subclass of mef , respectively. This study shows (i) the deﬁnitive presence of mef (E) in S. pyogenes and its global distribution, (ii) the presence of a mosaic variant of mef composed of mef (A) and mef (E), (iii) the previously undescribed presence of mef (I) in S. pyogenes , and (iv) the presence of a novel subclass of mef in S. pyogenes .
A Subset of Drosophila Integrator Proteins Is Essential for Efﬁcient U7 snRNA and Spliceosomal snRNA 3 (cid:1) -End Formation (cid:1) †

Proper gene expression relies on a class of ubiquitously expressed, uridine-rich small nuclear RNAs (snRNAs) transcribed by RNA polymerase II (RNAPII). Vertebrate snRNAs are transcribed from a unique promoter, which is required for proper 3 (cid:1) -end formation, and cleavage of the nascent transcript involves the activity of a poorly understood set of proteins called the Integrator complex. To examine 3 (cid:1) -end formation in Drosophila melanogaster , we developed a cell-based reporter that monitors aberrant 3 (cid:1) -end formation of snRNA through the gain in expression of green ﬂuorescent protein (GFP). We used this reporter in Drosophila S2 cells to determine requirements for U7 snRNA 3 (cid:1) -end formation and found that processing was strongly dependent upon nucleotides
ELECTRON MICROSCOPIC EVALUATION OF CISPLATIN CONJUGATED NANOGOLD AND LASER IRRADIATION ON HAMSTER BUCCAL POUCH CARCINOMA

The aim of the current study was to evaluate the ultrastructural illustration of apoptosis induced by gold nanoparticles (AuNPs) conjugated with cisplatin and laser irradiation on 7, 12- Dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouches {HBP(s)} carcinoma. Material and methods: The experimental animals used in the current study were fifty five golden syrian hamsters weighting 80-129 g, and obtained from the animal house, Cairo University. The experimental animals were divided into two main groups: Group A (normal group) 5 hamsters were taken, not treated and served as control. Group B: The remaining animals (50 hamsters) were treated with the same procedure: HBPs were painted for 18 weeks with DMBA, 3 times a week on alternative days, then the hamsters were randomly divided into the following five equal subgroups (10 hamsters) in each one. Group B1( DMBA treated group), group B2 (DMBA- AuNPs treated group), group B3 ( DMBA- AuNPs - laser radiation treated group), Group B4 ( DMBA- cisplatin-laser radiation treated group) and group B5 (DMBA- AuNPs conjugated with cisplatin laser radiation treated group). After termination to the treatment, fresh tissues from HBP were trimmed into small pieces in order to be processed and examined by transmission electron microscopy (TEM). Results: compared to results of other groups, DMBA induced carcinoma in group B animals . AuNPs conjugated with cisplatin and laser irradiation group showed signs of cellular apoptosis ranging from shrinkage of the nuclei, degeneration of the nuclear membrane to total cell autolysis. The other remaninig groups didn`t show any signs of apoptosis. Conclusions: AuNPs in conjunction with cisplatin and laser irradiation illustrated various signs of cancer cell apoptosis with TEM imaging. Intra-tumoral application of AuNPs in conjunction with cisplatin and visible laser irradiation was considered as a promising therapeutic agent in regression of HBP DMBA induced carcinoma.
Biological transformed cannabinoids bee pollen: A symbiosis approach on Apis mellifera raising protocol in Cannabis sativa L. (Hemp) cultivar in Samoeng District, Chiang Mai, Thailand

Honey bees ( Apis mellifera ) and Hemp plants ( Cannabis sativa L.) have been recognized as boosters in the world economy. Hemp pollens collected by honey bees for their nutrients and cannabinoids discrete from cannabis plants have not been syn-ergized in business management. A symbiosis approach was adopted in this novel experimental method. This research aimed to investigate the presences of Cannabinoids (CBD, THC and CBN) via a prototype of bee-raising protocol with the di ﬀ erent artiﬁcial fed supplements, foraging on the hemp plantation to collect hemp pollens. Theoretically, in-hived stored hemp pollen shall embrace active compounds as being abundance in hemp plants, thru biological transformation process. In the ﬁeld experiment, seed production hemp cultivated in Samoeng District, Chiang Mai was fully covered by mosquito net to conﬁne honey bees during male ﬂowering. The extraction of those cannabinoids of in-hived stored pollen samples and their contents were conducted by GC-MS technique. A repeated measure ANOVA model was conducted for statistical analysis. The experimental research results indicated the ﬁrst ever found of cannabinoids presented in in-hived stored pollen samples of all treatments. The statistical analysis among all treatments contained di ﬀ erent means of detected Cannabinoids (CBD, THC and CBN) contents, which were statistically signiﬁcant (P-value < 0.05) where the signiﬁcant level of 95%. The results were remarkable as shown due to presence of CBD, THC and CBN, as bioactive compounds, in in-hived honey bee pollens that would enlighten an opportunity in managing bee as hemp plantation either for further academic or business purposes.
Translational Glycobiology The N -glycosylation of immunoglobulin G as a novel biomarker of Parkinson ’ s disease

The use of the emerging “ omics ” technologies for large scale population screening is promising in terms of predictive, preventive and personalized medicine. For Parkinson ’ s disease, it is essen-tial that an accurate diagnosis is obtained and disease progression can be monitored. Immunoglobulin G (IgG) has the ability to exert both anti-in ﬂ ammatory and pro-in ﬂ ammatory effects, and the N -glycosylation of the fragment crystallizable portion of IgG is involved in this pro-cess. This study aimed to determine whether the IgG glycome could be a candidate biomarker for Parkinson ’ s disease. Ninety-four community-based individuals with Parkinson ’ s disease and a sex-, age- and ethnically-matched cohort of 102 individuals with mixed phenotypes, representative of a “ normally ” aged Caucasian controls, were investigated. Plasma IgG glycans were analyzed by ultra-performance liquid chromatography. Overall, seven glycan peaks and 11 derived traits had statistically signi ﬁ cant differences ( P < 8.06 × 10 − 4 ) between Parkinson ’ s disease cases and healthy controls. Out of the seven signi ﬁ cantly different glycan peaks, four were selected by Akaike ’ s Information Criterion to be included in the logistic regression model, with a sensitivity of 87.2% and a speci ﬁ city of 92.2%. The study suggested that there may be a reduced capacity for the IgG to inhibit Fc γ -RIIIa binding, which would allow an increased ability for the IgG to cause antibody-dependent cell cytotoxicity and a possible state of low-grade in ﬂ ammation in individuals with Parkinson ’ s disease. GP, glycan peak; HILIC, hydrophilic interaction liquid chromatography; IgG, immunoglobulin G; MBL, mannose-binding lectin; Nano-LC-ESI-MS/MS, nano-liquid chromatography-electron spray ionization-tandem mass spectrometry; OR, Odds ratio; ParkC, Parkinson ’ s Centre; PCA, principal components analysis; PD, Parkinson ’ s disease; UPLC, ultra-performance liquid chromatography.
Measurement of the gamma gamma* -&gt; eta c transition form factor

We study the reaction e þ e (cid:2) ! e þ e (cid:2) (cid:1) c , (cid:1) c ! K S K (cid:3) (cid:2) (cid:4) and obtain (cid:1) c mass and width values 2982 : 2 (cid:3) 0 : 4 (cid:3) 1 : 6 MeV =c 2 and 31 : 7 (cid:3) 1 : 2 (cid:3) 0 : 8 MeV , respectively. We ﬁnd (cid:1) ð (cid:1) c ! (cid:3)(cid:3) Þ B ð (cid:1) c ! K (cid:2) K(cid:2) Þ ¼ 0 : 374 (cid:3) 0 : 009 (cid:3) 0 : 031 keV , and measure the (cid:3)(cid:3) (cid:1) ! (cid:1) c transition form factor in the momentum transfer range from 2 to 50 GeV 2 . The analysis is based on 469 fb (cid:2) 1 of integrated luminosity collected at PEP-II with the BABAR detector at e þ e (cid:2) center-of-mass energies near 10.6 GeV.
PREPARATION, SYNTHESIS AND CHARACTERISATION OF SILVER NANOPARTICLES BY FISH SCALES OF CATLA CATLA AND THEIR ANTIBACTERIAL ACTIVITY AGAINST FISH PATHOGEN, AEROMONAS VERONII

Silver has been in use since time immemorial in the form of metallic silver, silver nitrate, silver sulfadiazine for the treatment of burns, wounds and several bacterial infections. But due to the emergence of several antibiotics the use of these silver compounds has been declined remarkably. Nanotechnology is gaining tremendous impacts in the present century due to its capability of modulating metals in to their nanosize, which drastically changes the chemical, physical and optical properties of metals. From the results, unveil that the synthesized silver nanoparticles were characterized by SEM, UV-VIS, and FT-IR spectroscopy. In the present work successfully synthesized AgNPs from the fish scales of Catla catla which are biocomposites of high ordered collagen fibres, hydroxyapatite and amino acids. AgNPs synthesis was confirmed by colour change, wave range of UV-VIS, FT-IR spectroscopy and the shape and size of the nanoparticles has made a remarkable comeback as potential antimicrobial agents. The synthesized silver nanoparticles were used to study the Antibacterial activity against the fish pathogen A.veronii by the application of 100µl of 1 M silver nanoparticle. Silver nanoparticles show greatest potentiality towards controlling the growth of bacteria.
Elliptic Equations with High-Contrast Coefficients and an Application to Multi-Scale Finite Element Methods

In this paper we design a multiscale finite element method using asymptotic expansions for elliptic equations with high-contrast coefficients applying recent results on the approximation of solutions of such equations. In particular, we use an asymptotic expansion of the solution for the case multiple high-conductivity inclusions. An important contribution is that we use a modification of the expansion that uses only local solutions to construct basis functions. In this case, we approximate the limit of the asymptotic expansion with a similar expansion constructed with localized harmonic characteristic functions. We present some representative numerical examples that confirm the theory.
Ablative fractional CO 2 laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study

Background: Poor sleep quality is associated with a decrease in quality of life in patients with major burn scars, combined with pruritus and pain. Few interventions have been reported to improve the sleep quality of patients with scars. In the current prospective cohort study, we investigated the efﬁcacy of CO 2 -ablative fractional laser (AFL) surgery vs conventional surgery in post-burn patients with hypertrophic scars with sleep quality as the primary study outcome. Methods: In total 68 consecutive patients undergoing scar surgical treatment were recruited, including a CO 2 -AFL surgery cohort ( n = 35) and a conventional surgery cohort ( n = 33). A subgroup from the AFL cohort was selected. Sleep quality, pain and pruritus were evaluated. Multiple linear regression analyses were performed to reveal the effect of CO 2 -AFL surgery. Results: The CO 2 -AFL surgery cohort had signiﬁcantly lower Pittsburgh sleep quality index (PSQI) global scores than the conventional surgery cohort after the last surgical treatment. In the subgroup of patients receiving hardware sleep monitoring, CO 2 -AFL markedly increased deep sleep time, deep sleep efﬁciency and reduced initial sleep latency. Compared to the conventional surgery cohort, the CO 2 -AFL cohort presented signiﬁcantly lower pain and pruritus scores. Correlation analysis showed pain and pruritus were signiﬁcantly associated with PSQI scores, and there were also signiﬁcant correlations between pain and pruritus scores. Multiple linear regression analysis showed that surgery method was negatively linearly correlated with visual analog scale (VAS) pain score, brief pain inventory (BPI) total, VAS pruritus score, 5-D itch scale total, four-item itch questionnaire (FIIQ) total and PSQI total. and and of The of was associated with
Low copy of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis

Introduction: Low copy number (CN) of the Fc gamma receptor 3B ( FCGR3B ) gene has been associated with systemic autoimmune disease. This receptor for IgG is present almost exclusively on neutrophils and plays a role in their interaction with immune complexes. At present the relationship between FCGR3B and rheumatoid arthritis (RA) is unclear. The aim of the present study was to investigate whether low CN of the FCGR3B gene is associated with susceptibility to RA. Method: The FCGR3B CN was determined using a custom Taqman ® CN assay (Hs04211858; Applied Biosystems, Foster City, CA, USA) in 197 RA patients, recruited from a tertiary setting, and in 162 population matched controls. Odds ratios for low CN (< 2) and high CN (> 2), both relative to the normal diploid 2CN, were estimated by logistic regression. Results: A significant association between RA and low FCGR3B CN was observed, with frequencies of 13.7% in RA patients compared with 6.2% in controls (odds ratio 2.5, 95% confidence interval 1.2 to 5.4, P = 0.017). No association was observed between low CN and the presence of rheumatoid factor, anti-cyclic citrullinated peptide antibodies or radiographic erosions in RA patients. A meta-analysis including six previous studies confirmed an association between RA and low FCGR3B CN (odds ratio 1.47, 95% confidence interval 1.13 to 1.92, P = 0.004). Conclusions: The present study confirms that a low CN of the FCGR3B gene is associated with susceptibility to RA. The association may be stronger in patients recruited from a tertiary setting, which may relate to disease severity and/or complications. The mechanism of susceptibility remains unclear and further study is required.
RED CELLS, IRON, AND ERYTHROPOIESIS Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease

During maturation to an erythrocyte, a reticulocyte must eliminate any residual organelles andreduceitssurfaceareaandvolume.Hereweshowthisinvolvesanovelprocesswhereby large, intact, inside-out phosphatidylserine (PS)-exposed autophagic vesicles are extruded. CellsurfacePSisawell-characterizedapoptoticsignalinitiatingphagocytosis.Inperipheral blood from patients after splenectomy or in patients with sickle cell disease (SCD), the number of circulating red cells exposing PS on their surface is elevated. We show that in these patients PS is present on the cell surface of red cells in large ( ∼ 1.4 m m) discrete areas corresponding to autophagic vesicles. The autophagic vesicles found on reticulocytes are identical to those observed on red cells from splenectomized individuals and patients with SCD. Our data suggest the increased thrombotic risk associated with splenectomy, and patients with hemoglobinopathies is a possible consequence of increased levels of circulating maturereticulocytes expressing inside-out PS-exposed autophagic vesicles because of asplenia. ( Blood 2015;126(15):1831-1834)
Comprehensive Proﬁling of Blood Coagulation and Fibrinolysis Marker Reveals Elevated Plasmin-Antiplasmin Complexes in Parkinson’s Disease

especially in red blood cells (erythrocytes), but also in plasma, saliva and platelets. This in turn raises the question whether presumably dysfunctional α -Syn affects the other enclosed constituents (haemoglobin, mediators of haemostasis, immunoglobulins and clotting factors). We thus searched for a potential impact in the aforementioned peripheral blood compartments in PD. Abstract: Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease. Accumulating evidence demonstrates that alpha-synuclein ( α -Syn), an apparently predominant neuronal protein, is a major contributor to PD pathology. As α -Syn is also highly abundant in blood, particularly in red blood cells (RBCs) and platelets, this in turn raises the question on the function of presumably dysfunctional α -Syn in “peripheral” cells and its putative effect on the other enclosed constituents. Herein, we detected the internal variance in erythrocytes of PD patients by Raman spectroscopy, but no measurable amount of erythrocytic behavioural change (eryptosis) or any haemoglobin variation was noticed. An elevated level of plasmin-antiplasmin complexes (PAP) was observed in the plasma of PD patients, indicating activation of the ﬁbrinolytic system, but platelet activation after thrombin stimulation was not altered. Sex-speciﬁc patterns were noticed for blood coagulation factor XIII and factor XII activity in PD patients. Additionally, the alterations in homocysteine levels which have often been observed in PD patients were found to be independent from L-DOPA usage and PAP levels. Furthermore, a selective gene expression analysis identiﬁed subsets of genes related to different blood-associated compartments (RBCs, platelets, coagulation-ﬁbrinolysis) also involved in PD-related pathways.
Arterial baroreﬂex regulation of regional vascular conductance at rest and during exercise

Arterial baroreﬂex regulation of regional vascular conductance at rest and during exercise. Am R1634– R1642, 2000. —We tested the hypothesis that dynamic exercise resets the operating point and attenuates the spontaneous gain of the arterial baroreﬂex regulation of mesenteric and hindlimb vascular conductance in hypertensive rats. Eleven adult male spontaneously hypertensive rats were chronically instrumented with left carotid arterial catheters and Doppler ultrasonic ﬂow probes around the superior mesenteric and left common iliac arteries. After the rats recovered, arterial baroreﬂex function was examined by recording reﬂex changes in conductance in response to spontaneous changes in mean arterial pressure before exercise and during steady-state treadmill running at 6 and 18 m/min. Dynamic exercise reduced the spontaneous baroreﬂex gain of mesenteric conductance (by 51 and 36%) and maximum mesenteric conductance (by 24 and 32%) at 6 and 18 m/min, respectively. In sharp contrast, dynamic exercise increased the spontaneous maximum iliac conductance (by 32 and 47%) without changing the spontaneous gain. Sinoaortic denerva- tion eliminated the relationship between mean arterial pressure and conductance by reducing the mesenteric (92%) and iliac (68%) vascular conductance gain. These results demonstrate that dynamic exercise has differential effects on the regulation of mesenteric and iliac vascular conductance in hypertensive rats.