Miracle-dz/UniFAR-FTUs huggingface dataset:
Isoflavonoid composition and antioxidant activity on elicited and non-elicited sprouts of six soy cultivars grown in Colombia

: Isoflavonoid composition of freshly harvested soy sprouts of six cultivars grown in Colombia was analyzed. Evaluations on the effect of storage time at 12 °C and exogenous application of the elicitor 2,6-dichloro isonicotinic acid (INA) were carried out to establish their influence in the ability of soy sprouts for synthesizing isoflavonoids. In addition, elicited and non-elicited sprouts of soy cultivar Soy SK-7 was assessed for total phenolic content and antioxidant activity according to the growth stage (VE, VC, and V1) and tissues (cotyledon-epicotyl and hypocotyl-root). Isoflavonoid content and antioxidant capacity were dependent on the cultivar, growth stage, tissue, and storage time at 12 °C. Growth stages VE and V1 and the hypocotyl-root exhibited the highest total phenolic content and antioxidant activity. In general, 6”-O -malonylgenistin, daidzin and genistin were the major constituents in the cultivars. Soy SK-7 and Panorama 358 displayed the highest amounts of 6”-O -malonylgenistin (155.9 µg/g) and daidzin (83.5 µg/g), respectively. Results showed that the isoflavonoids and phenolic contents and antioxidant activity were significantly increased by application of INA. This information can be useful to produce soybean sprouts with increased amounts of bioactive compounds and improved response to abiotic and biotic stresses.
Derivation and validation of the nonlinear radar range equation

The radar range equation for detecting targets using linear radar has been defined and derived many times for many different applications. The nonlinear radar range equation has been defined in the literature but a step by step derivation is lacking and no experimental validation has been shown. This paper starts with a nonlinear system model and provides simulated and experimental validation for the model. Once the model is validated, the model is used to derive the nonlinear radar range equation for nonlinear radar. Key differences between the linear and nonlinear radar range equation will be emphasized.
Safety and Efficacy of Ab Interno XEN 45 Gel Stent in Patients with Glaucoma and High Myopia

This study reports on the safety and efficacy of Xen 45 in patients with glaucoma and high myopia. It was a retrospective study including patients with high myopia (>6D) who underwent Xen implant with 2 years of follow-up. The primary outcome was to report the incidence of hypotony (IOP ≤ 5 mmHg) and hypotony-related complications. Patients with high myopia treated with mitomycin-C-augmented trabeculectomy were included as a control group. We included 14 consecutive patients who underwent Xen implant (seven eyes) and trabeculectomy (seven eyes). The mean myopia was −14.71 ± 5.36 and −15.07 ± 6.11 in the trabeculectomy and Xen groups, respectively (p > 0.05). The success rate and the mean IOP at 1 and 2 years from the intervention were statistically comparable between the two groups. The group undergoing trabeculectomy showed a higher incidence of hypotony (six eyes (85.71%) vs. two eyes (28.57%)) and hypotony maculopathy (three eyes (42.86%) vs. zero eyes (0%)) and required more postoperative procedures. Patients with high myopia were at higher risk of hypotony-related complications after trabeculectomy. The Xen implant can achieve an IOP control comparable to trabeculectomy with a significantly better safety profile and can be considered as an option for the management of patients with high myopia and glaucoma.
Postulates for General Quantum Mechanics

We present in this paper a set of postulates for a physical system and deduce from these the main general features of the quantum theory of stationary states. Our theory is strictly operational in the sense that only the observables of the physical system are involved in the postulates. The collection of all bounded self-adj oint operators on a Hilbert space, which has previously been used as a mathematical model for the observables in quantum mechanics, satisfy the postulates, as do a variety of considerably more general mathematical structures. We show that for any two observables there exists a pure state of the system (this term being defined essentially as done by von Neumann and Weyl) in which they have different (expectation) values. Each observable has a spectral resolution, and a state of the system induces, in a natural way, a probability distribution on the range of spectral values of each observable. A number of observables are simultaneously observable if and only if they commute (although the product of two observables is not defined in general, a reasonable notion of commutativity can be introduced). Inasmuch as Hilbert space plays no role in our theory, our proofs are necessarily of a different character from the proofs of these results for the case of the system of all bounded selfadjoint operators. Actually, Hilbert space appears to be somewhat inadequate as a state space even for the latter system, in that there exist pure states of the system which cannot be represented in the usual way by rays of the Hilbert space. The postulates are partly algebraic and partly metric. The algebraic postulates require essentially that an observable can be multiplied by real numbers and raised to integral powers, and that any two observables can be added. It is assumed that the usual algebraic laws are satisfied so that (1) the observables can be treated like the elements of a linear space, and (2) the usual rules for dealing with polynomials in one variable with real coefficients remain valid when the variable is replaced by an observable. It is not assumed that two observables have a product. The metric postulates require that for each observable there be defined a kind of maximum numerical value, which plays the part of a norm, and has various properties in accord with its physical significance. While this norm is quite essential to the development of the theory, an interesting consequence of the theory is that the norm can be (uniquely) defined in a purely algebraic fashion. This shows that the objective features of a physical system,-the spectral values and probability distributions of the observables, and the pure states,-are completely determined by the algebra of observables, i.e., by the rules for addition, scalar multiplication, and powers, of observables.
Development and application of a Ni-Ti interatomic potential with high predictive accuracy of the martensitic phase transition

Phase transitions in nickel-titanium shape-memory alloys are investigated by means of atomistic simulations. A second nearest-neighbor modified embedded-atom method interatomic potential for the binary nickel-titanium system is determined by improving the unary descriptions of pure nickel and pure titanium, especially regarding the physical properties at finite temperatures. The resulting potential reproduces accurately the hexagonal-close-packed to body-centered-cubic phase transition in Ti and the martensitic B2-B19′ transformation in equiatomic NiTi. Subsequent large-scale molecular-dynamics simulations validate that the developed potential can be successfully applied for studies on temperatureand stress-induced martensitic phase transitions related to core applications of shape-memory alloys. A simulation of the temperature-induced phase transition provides insights into the effect of sizes and constraints on the formation of nanotwinned martensite structures with multiple domains. A simulation of the stress-induced phase transition of a nanosized pillar indicates a full recovery of the initial structure after the loading and unloading processes, illustrating a superelastic behavior of the target system.
Safety and Immunogenicity of the NVX-CoV2373 Vaccine as a Booster in Adults Previously Vaccinated with the BBIBP-CorV Vaccine: An Interim Analysis

This phase 3 observer-blind, randomized, controlled study was conducted in adults [≥]18 years of age to assess the safety and immunogenicity of NVX-CoV2373 as a heterologous booster compared to BBIBP-CorV when utilized as a homologous booster. Approximately 1,000 participants were randomly assigned in a 1:1 ratio to receive a single dose of NVX-CoV2373 or BBIBP-CorV after prior vaccination with 2 or 3 doses of BBIBP-CorV. Solicited adverse events (AEs) were collected for 7 days after vaccination. Unsolicited AEs were collected for 28 days following the booster dose and serious adverse and adverse events of special interest (AESI) were collected throughout the study. For this interim analysis, anti-spike IgG and neutralizing antibodies against SARS-CoV-2 were measured at baseline, day 14, and day 28. The study achieved its primary non-inferiority endpoint and also demonstrated statistically higher neutralization responses of approximately 6-fold when NVX-CoV2373 was utilized as a heterologous booster compared with BBIBP-CorV as a homologous booster. Both vaccines had an acceptably low reactogenicity profile and no new safety concerns were found. Heterologous boosting with NVXCoV2373 was a highly immunogenic and safe vaccine regimen in those previously vaccinated with BBIBP-CorV.
Comorbid hypertension and its associated factors among diabetic outpatients in West Shewa Zone public hospitals, Ethiopia: an institution based cross-sectional study

Hypertension is the main contributor to the worldwide burden of disease and it is frequently coexists with diabetes and exacerbates its complications. The purpose of this study was to evaluate the prevalence and determinants of hypertension among diabetic outpatients at West Shewa Zone public hospitals. Facility based cross-sectional study was conducted from June to December, 2021 among diabetic patients attending their follow up at West Shewa public hospitals, Ethiopia. Data were collected using interviewer administered pretested structured questionnaire. A variable having a p-value of <0.25 in the bivariable analysis were subjected to multivariable analysis to avoid confounding variables effect. Adjusted odds ratios were calculated at 95% confidence interval and considered significant with a p-value of < 0.05. A total of 390 participants were included in the study. Their mean age was 46.45 years (15.6) years. Our study found that there was high prevalence of hypertension among diabetic patients. Age and above 50 year, obesity, family history of hypertension and being single were associated with hypertension among participants. Hence, necessary actions are recommended by responsible bodies for identified problems.
Cluster-Based Toxicity Estimation of Osteoradionecrosis via Unsupervised Machine Learning: Moving Beyond Single Dose-Parameter Normal Tissue Complication Probability by Using Whole Dose-Volume Histograms for Cohort Risk Stratification

Purpose: Given the limitations of extant models for normal tissue complication probability estimation for osteoradionecrosis (ORN) of the mandible, the purpose of this study was to enrich statistical inference by exploiting structural properties of data and provide a clinically reliable model for ORN risk evaluation through an unsupervised-learning analysis. Materials and Methods: The analysis was conducted on retrospective data of 1,259 head and neck cancer (HNC) patients treated at the University of Texas MD Anderson Cancer Center between 2005 and 2015. The (structural) clusters of mandibular dose-volume histograms (DVHs) were identified through the K-means clustering method. A soft-margin support vector machine (SVM) was used to determine the cluster borders and partition the dose-volume space. The risk of ORN for each dose-volume region was calculated based on the clinical risk factors and incidence rates. Results: The K-means clustering method identified six clusters among the DVHs. Based on the first five clusters, the dose-volume space was partitioned almost perfectly by the soft-margin SVM into distinct regions with different risk indices. The sixth cluster overlapped the others entirely; the region of this cluster was determined by its envelops. These regions and the associated risk indices provide a range of constraints for dose optimization under different risk levels. Conclusion: This study presents an unsupervised-learning analysis of a large-scale data set to evaluate the risk of mandibular ORN among HNC patients. The results provide a visual risk-assessment tool (based on the whole DVH) and a spectrum of dose constraints for radiation planning.
Influence of Single External Store on Geometrical Nonlinear Flutter of High-aspect-ratio Wings

High-altitude and long-endurance UAVs, distributed electric propulsion aircraft and large passenger aircraft often use high-aspect-ratio wings, which have obvious geometric nonlinear large deformation effect, and are usually arranged with a certain number of external stores, which have an impact on their geometric nonlinear aeroelastic characteristics. Based on the “quasi-linear” hypothesis, the updated Lagrange incremental finite element method and doublet-lattice method are used to perform the geometrically nonlinear static aeroelastic analysis, and the mass, stiffness and aerodynamic matrices of large deformation are updated, and the geometrically nonlinear flutter characteristics of high-aspect-ratio wings are calculated. The influence of the position and mass of the external store on geometrical nonlinear flutter characteristics of high-aspect-ratio wing structure is investigated. Results show that the change of the position and mass of the external store causes the relative position between the elastic axis and the center of gravity of the wing, and the wing’s large deformation equilibrium state to change, resulting in differences in the stiffness characteristics of the wing and the natural vibration frequency of the equilibrium state, thus affecting the wing flutter characteristics. When a single external store is installed near the wing root, changing the mass and direction of the store has no significant effect on the geometric nonlinear flutter characteristics of the wing. The improvement of wing flutter speed is most obvious when the hanging point is moved to the leading edge of the wing near 0.65 times the wingspan.
Calculation Method of Hosting Capacity for Distributed Grid-connected Photovoltaic Based on IGWO

In recent years, the distribution grid has been taking more and more risks due to the large-scale access of distributed photovoltaics (DPV), including potential problems such as voltage overrun and tidal current reversal, which seriously threaten grid security. Therefore, studying the maximum access capacity of distributed photovoltaics in the distribution grid is a research need nowadays. In this paper, we first establish a distributed PV grid-connected optimization operation model for distribution networks, taking into account multi-dimensional constraints such as voltage, load capacity, and active power, and then propose a grey wolf optimization based on particle swarm and Bernoulli chaos mapping, using chaos mapping initialization population, nonlinear convergence factor, and position update idea in the particle swarm algorithm to increase the initial population diversity and solution accuracy. Then, we use the improved grey wolf optimization algorithm (IGWO) as the basis for solving the maximum access capacity of distributed PV for distribution networks. Finally, simulations are conducted on the IEEE-33 node system to exemplify the previously developed model and algorithm.
Transient loss and recovery of oral chemesthesis, taste and smell with COVID-19: a small case-control series

Anosmia is common with respiratory virus infections, but loss of taste or chemesthesis is rare. Reports of true taste loss with COVID-19 were viewed skeptically until confirmed by multiple studies. Nasal menthol thresholds are elevated in some with prior COVID-19 infections, but data on oral chemesthesis are lacking. Many patients recover quickly, but precise timing and synchrony of recovery are unclear. Here, we collected broad sensory measures over 28 days, recruiting adults (18-45 years) who were COVID-19 positive or recently exposed (close contacts per U.S. CDC criteria at the time of the study) in the first half of 2021. Participants received nose clips, red commercial jellybeans (Sour Cherry and Cinnamon), and scratch-n-sniff cards (ScentCheckPro). Among COVID-19 cases who entered the study on or before Day 10 of infection, Gaussian Process Regression showed odor identification and odor intensity (two distinct measures of function) each declined relative to controls (close contacts who never developed COVID-19), but effects were larger for intensity than identification. To assess changes during early onset, we identified four COVID-19 cases who enrolled on or prior to Day 1 of their illness: this allowed for visualization of baseline ratings, loss, and recovery of function over time. Four controls were matched for age, gender, and race. Variables included sourness and sweetness (Sour Cherry jellybeans), oral burn (Cinnamon jellybeans), mean orthonasal intensity of four odors (ScentCheckPro), and perceived nasal blockage. Data were plotted over 28 days, creating panel plots for the eight cases and controls. Controls exhibited stable ratings over time. By contrast, COVID-19 cases showed sharp deviations over time. No single pattern of taste loss or recovery was apparent, implying different taste qualities might recover at different rates. Oral burn was transiently reduced for some before recovering quickly, suggesting acute loss may be missed in data collected after acute illness ends. Changes in odor intensity or odor identification were not explained by nasal blockage. Collectively, intensive daily testing shows orthonasal smell, oral chemesthesis and taste were each altered by acute COVID-19 infection, and this disruption was dyssynchronous for different modalities, with variable loss and recovery rates across modalities and individuals.
Insulinotropic effect of endogenous incretins is greater after gastric bypass than sleeve gastrectomy despite diminished beta-cell sensitivity to plasma incretins

ABSTRACT Background/Aims: Prandial hyperinsulinemia after Roux-en Y gastric bypass surgery (GB), and to lesser degree after sleeve gastrectomy (SG), has been attributed to rapid glucose flux from the gut and increased insulinotropic gut hormones. However, {beta}-cell sensitivity to exogenous incretin is markedly reduced after GB. This study examines the effect of GB versus SG on prandial glycemia and {beta}-cell response to increasing concentrations of endogenous incretins. Methods: Glucose kinetics, insulin secretion rate (ISR), and incretin responses to 50-gram oral glucose ingestion were compared between 10 non-diabetic subjects with GB versus 9 matched individuals with SG and 7 non-operated normal glucose tolerant controls (CN) on two days with and without administration of 200 mg sitagliptin. Results: Fasting glucose and hormonal levels were similar among 3 groups. Increasing plasma concentrations of endogenous incretins by 2-3-fold diminished post-OGTT glycemia and increased {beta}-cell secretion in all 3 groups (p<0.05), but insulin secretion per insulin sensitivity (i.e., disposition index) was increased only in GB (p<0.05 for interaction). As a result, sitagliptin administration led to hypoglycemia in 3 of 10 GB. Yet, plot of the slope of ISR versus the increase in endogenous incretin concentration was smaller after GB compared to both SG and CN. Conclusion: Augmented glycemic-induced {beta}-cell response caused by enhanced incretin activity is unique to GB and not shared with SG. However, the {beta}-cell sensitivity to increasing concentrations of endogenous incretin is smaller after bariatric surgery, particularly after GB, compared to non-operated controls, indicating a long-term adaptation of gut-pancreas axis after these procedures.
The rapid emergence of Salmonella Typhi with decreased ciprofloxacin susceptibility following an increase in ciprofloxacin prescriptions in Blantyre, Malawi

Ciprofloxacin is the first-line drug for treating typhoid fever in many high burden countries in Africa, but the emergence of non-susceptibility poses a grave challenge to public health programmes. Through enhanced surveillance as part of vaccine evaluation, we set out to investigate the occurrence and determinants of ciprofloxacin non-susceptibility in Blantyre, Malawi. We performed systematic typhoid fever and antibiotic prescription surveillance in two health centres in Blantyre, Malawi between 01/10/2016 and 31/10/2019, as part of the STRATAA and TyVAC studies. Blood culture isolates from study participants underwent i) pefloxacin screening and ciprofloxacin E-tests to identify ciprofloxcain non-susceptibility and ii) whole genome sequencing (WGS) to identify drug resistance mutations and phylogenetic relationships between non-susceptible and sensitive isolates. We constructed generalised linear regression models to investigate associations between ciprofloxacin prescription rates and S. Typhi isolates with Quinolone Resistance Determining Region (QRDR) mutations. We carried out 11295 blood cultures and microbiologically confirmed 239 cases of typhoid fever, with isolates from 193 participants sequenced (mean age of participants with sequenced genomes 12.8 years, 47% male). Between October 2016 and August 2019 2% (n=4/175) of WGS-confirmed typhoid fever cases were caused by S. Typhi with QRDR mutations, compared with 33% (n=6/18) in September and October 2019. Nine of the ten S. Typhi with QRDR mutations had a decreased ciprofloxacin susceptibility phenotype. Every additional prescription of ciprofloxacin given to study participants in the preceding month was associated with a 4.2% increase in the relative risk of isolating S. Typhi with a QRDR mutation (95% CI, 1.8-7.0%, p=0.0008). Phylogenetic analysis showed that S. Typhi isolates with QRDR mutations in September/October 2019 belonged to two distinct sub-clades encoding two different QRDR mutations, and were closely related (0-6 SNPs) to susceptible S. Typhi endemic to Blantyre. We have shown a close temporal association between empiric antimicrobial usage with an increase of fluoroquinolone non-susceptibility in S. Typhi, with two sub-clades responsible for the increase. Decreasing ciprofloxacin usage by improving typhoid diagnostics could help to limit the emergence of resistance.
FERROKINETIC EVALUATION OF PATIENTS WITH ACUTE CORONARY SYNDROME AT A SOUTH AMERICAN HOSPITAL, PILOT STUDY.

Introduction : Alterations in the ferrokinetic profile are associated with cardiovascular disease, and the short- and long-term prognosis of these alterations is currently unknown. Design : Prospective cohort analytical observational study Methods: To determine the prognostic value of the alterations of the ferrokinetic profile in patients with myocardial infarction with and without ST-segment elevation, in a Health institution from July 2017 to May 2018. Results : From 72 patients , the main affected gender was male, in ages over 56 years old, the infarction with ST elevation being the most frequent. Among the associated comorbidities, the main one was hypertension with (n: 22; 53.7%) for infarction with elevation and (n: 23; 74.2%) for infarction without ST elevation. The most frequent alteration of the parameters of the ferrokinetic profile studied, was the iron deficit, found in (n:15; 36.6%) of the patients with ST elevation and (n:13; 41.9%) without ST elevation. Low levels of hemoglobin were present at admission (n:10; 24.4%) of the subgroup with ST elevation and (n:10; 32.3%) for no ST elevation, increasing the percentage to (n:13; 31.7%) (RR: 2) (95% CI -0.131- 30.63), associated with low hemoglobin values at day 7 of hospitalization. There were 2 deaths (2.77%), which presented low levels of iron without anemia and infarction with ST elevation complicated by cardiogenic shock. Conclusions : iron deficiency is a common comorbidity with a high mortality rate, and the decrease in hemoglobin after hospital admission was related to mortality, so both parameters should be taken into account in Infarction and cardiovascular disease.