Miracle-dz/UniFAR-FTUs huggingface dataset:
Architectural experience: clarifying its central components and their relation to core affect with a set of first-person-view videos

When studying architectural experience in the lab, it is of paramount importance to use a proxy as close to real-world experience as possible. Whilst still images visually describe real spaces, and virtual reality allows for dynamic movement, each medium lacks the alternative attribute. To merge these benefits, we created and validated a novel dataset of valenced videos of first-person-view travel through built environments. This dataset was then used to clarify the relationship of core affect (valence and arousal) and architectural experience. Specifically, we verified the relationship between valence and fascination, coherence, and hominess - three key psychological dimensions of architectural experience which have previously been shown to explain aesthetic ratings of built environments. We also found that arousal is only significantly correlated with fascination, and that both are embedded in a relationship with spatial complexity and unusualness. These results help to clarify the nature of fascination, and to distinguish it from coherence and hominess when it comes to core affect. Moreover, these results demonstrate the utility of a video dataset of affect-laden spaces for understanding architectural experience. Highlights - Developed a video database of first-person-view journeys through built environments - We explored how core affect and architectural experience relate through the videos - Previous results are supported: valence ties to fascination, coherence and hominess - Arousal correlates only with fascination, and not coherence or hominess - Arousal and fascination are tied to spatial complexity and unusualness
Reactivating ordinal position information from auditory sequence memory in human brains

Retaining a sequence of events in their order is a core ability of many cognitive functions, such as speech recognition, movement control, and episodic memory. Although content representations have been widely studied in working memory (WM), little is known about how ordinal position information of an auditory sequence is retained in the human brain as well as its coding characteristics. In fact, there is still a lack of an efficient approach to directly access the stored ordinal position code, since the neural activities enter a relatively ‘activity-silent’ WM state during WM retention. Here participants performed an auditory sequence WM task with their brain activities recorded using electroencephalography (EEG). We developed new triggering events that could successfully reactivate neural representations of ordinal position from the ‘activity-silent’ retention stage. Importantly, the rank reactivation is further related to recognition behavior, confirming its indexing of WM storage. Furthermore, the ordinal position code displays an intriguing ‘stable-dynamic’ format, i.e., undergoing the same dynamic neutral trajectory during both encoding and retention (whenever reactivated). Overall, our results provide an effective approach to access the behaviorally-relevant ordinal position information in auditory sequence WM and reveal its new temporal characteristics.
A full spectrum PNGase activity analysis of R328 mutations on NGLY1

In humans, N-glycanase 1 (NGLY1; Peptide: N-glycanase, PNGase) is responsible for the deglycosylation of misfolded glycoproteins. Pathogenic mutations in NGLY1 cause a clinical condition known as congenital disorder of deglycosylation (NGLY1-CDDG), a rare autosomal recessive disease first reported in 2012. Although NGLY1-CDDG was diagnosed through whole-exome or whole-genome sequencing and by evaluating the expression levels of NGLY1, the clinical relevance of a detected mutation in NGLY1 needs to be further confirmed. In this study, an in vitro enzymatic assay system was established to evaluate the thermal stability and substrate specificity of NGLY1, as well as the optimum reaction conditions for its activity. A panel of all mutations at the amino acid site R328 in NGLY1 was subjected to this assay. The results revealed that R328A, R328D, R328E, R328F, R328G, R328I, R328P, R328V, R328W, and R328Y were dysfunctional mutations (10/19); NGLY1 mutations with R328H and R328T exhibited similar activity as wild-type NGLY1 (2/19); and NGLY1 mutations with R328C, R328K, R328L, R328M, R328N, R328Q, and R328S showed decreased activity (7/19) compared to wild-type NGLY1. In addition, the effect of potential regulatory compounds, including N-acetyl-L-cysteine and dithiothreitol, on NGLY1 was examined. This in vitro assay may serve as a standard protocol to facilitate rapid diagnosis of all mutations on NGLY1 and a practical screening method for drugs and compounds with potential therapeutic value for NGLY1-CDDG patients.
Asynchrony rescues statistically optimal group decisions from information cascades through emergent leaders

It is usually assumed that information cascades are most likely to occur when an early but incorrect opinion spreads through the group. Here we analyse models of confidence-sharing in groups and reveal the opposite result: simple but plausible models of naïve Bayesian decision-making exhibit information cascades when group decisions are synchronous; however, when group decisions are asynchronous, the early decisions reached by Bayesian decision makers tend to be correct, and dominate the group consensus dynamics. Thus early decisions actually rescue the group from making errors, rather than contribute to it. We explore the likely realism of our assumed decision-making rule with reference to the evolution of mechanisms for aggregating social information, and known psychological and neuroscientific mechanisms.
Modeling protected species distributions and habitats to inform siting and management of pioneering ocean industries: A case study for Gulf of Mexico aquaculture

Marine Spatial Planning (MSP) provides a process that uses spatial data and models to evaluate environmental, social, economic, cultural, and management trade-offs when siting ocean industries. Aquaculture is the fastest-growing food sector in the world. The U.S. has substantial opportunity for offshore aquaculture development given the size of its exclusive economic zone, habitat diversity, and variety of candidate species for cultivation. However, many protected species rely upon habitats that overlap with promising aquaculture areas. Siting surveys, farm construction, operations, and decommissioning can alter the habitat and behavior of animals in the vicinity of these activities. Vessel activity, underwater noise, and physical interactions between protected species and farms can potentially increase the risk of injury or cause direct mortality. In 2020, the U.S. Gulf of Mexico was identified as one of the first regions to be evaluated for offshore aquaculture opportunities as directed by a Presidential Executive Order. We developed a generalized scoring model for protected species data layers that captures vulnerability using species conservation status and demographic information. We applied this approach to data layers for eight species listed under the Endangered Species Act, including five species of sea turtles, Rice’s Whale, Smalltooth Sawfish, and Giant Manta Ray. We evaluated several methods for scoring (e.g., arithmetic mean, geometric mean, product, lowest scoring layer) and created a combined protected species data layer that was used within a multi-criteria decision-making modeling framework for MSP. The product approach for scoring provided the most logical ordering of and the greatest contrast in site suitability scores. This approach provides a transparent and repeatable method to identify aquaculture site alternatives with the least conflict with protected species. These modeling methods are transferable to other regions, to other sensitive or protected species, and for spatial planning for other ocean-uses.
Polycomb-mediated repression of paternal chromosomes maintains haploid dosage in diploid embryos of Marchantia

Complex mechanisms regulate gene dosage throughout eukaryotic life cycles. Mechanisms controlling gene dosage have been extensively studied in animals, however it is unknown how generalizable these mechanisms are to diverse eukaryotes. Here, we use the haploid plant Marchantia polymorpha to assess gene dosage control in its short-lived diploid embryo. We show that throughout embryogenesis, paternal chromosomes are repressed resulting in functional haploidy. The paternal genome is targeted for genomic imprinting by the Polycomb mark H3K27me3 starting at fertilization, rendering the maternal genome in control of embryogenesis. Maintaining haploid gene dosage by this new form of imprinting is essential for embryonic development. Our findings illustrate how haploid-dominant species can regulate gene dosage through paternal chromosome inactivation and initiates the exploration of the link between life cycle history and gene dosage in a broader range of organisms.
PPA_A_353128 949..956

1Department of Vascular Surgery, West China Hospital, Sichuan University, West China School of Nursing, Sichuan University, Chengdu, People’s Republic of China; 2Department of Orthopedics, Orthopedic Reaserch Institute, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 3Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu, People’s Republic of China
The Correlation between Apolipoprotein B Levels and Inflammatory Markers in Obese Individuals

: Apolipoprotein B (ApoB) levels reflect the total number of potentially atherogenic particles that can predict cardiovascular risk. The purpose of this study was to assess if the ApoB in obese subjects is associated with inflammatory markers. This cross-sectional study was conducted in 80 obese patients at Haji Adam Malik Hospital, Medan, Indonesia. Of the 80 patients studied, the average age was 38.95 + 8.13 years old. There was a strong positive correlation between ApoB and triglycerides (r=0.44, P <0.001), low-density lipoprotein cholesterol (r=0.74, P <0.001), and HOMA-IR (r=0.31, P =0.005). However, no strong correlation with the inflammatory markers were seen; adiponectin (r=-0.23, P =0.41) and Chemerin (r=0.021, P =0.851). In obesity, ApoB is significantly associated with lipid and insulin resistance, as a risk factor for cardiovascular disease.
University of and the creation of a tumour-conducive microenvironment in neuroblastoma

ABC transporters have long been implicated in the promotion of cancer survival due to their role in cytotoxic drug efflux and conferring MDR. The broad substrate specificity associated with ABC transporters, particularly in the ABCC subfamily, is however implicating ABC transporters in the promotion of carcinogenesis independent of drug efflux. Eicosanoids including PGE2 and cysteinyl leukotrienes are among the substrates transported by ABCC transporters and are main players in the body’s natural inflammatory response and more importantly, tumour -promoting inflammation. Neuroblastoma cell lines overexpressing the MycN oncogene are documented to heavily expand their ABC expression profile, with upregulations seen in both ABCC1 and ABCC4. This project aims to assess how the expression of certain ABCs like ABCC1 and 4 affects extracellular concentrations of eicosanoids by inhibiting their transport, at the same time assessing how ABC expression affects the migratory potential of cells and potentially implicating PGE2 and cysteinyl leukotrienes in the more aggressive phenotypes demonstrated by NB cell lines.
ThyroglobulinNear Cathepsin Cleavage Sites in Identification of Pathogenic T Cell Epitopes

Experimental autoimmune thyroiditis, induced in mice after challenge with thyroglobulin (Tg), is known to be under the genetic control of the H2A k locus. Because cathepsins are known to inﬂuence proteolytic processing of Tg in vivo, we examined in this study whether putative H2A k -binding Tg epitopes, located near cathepsin cleavage sites within mouse Tg, have immunopathogenic properties. Cathepsin L, B, and D cleavage sites in mouse Tg were predicted based on homology with known cathepsin cleavage sites in rabbit Tg. We used an algorithm-based approach to identify H2A k -binding motifs within 20-aa residue segments adjacent to cathepsin cleavage sites, and ﬁve 12mer peptides encompassing these sequences were synthesized. Two of them, p2369 (aa 2369– 2380) and p2439 (aa 2439–2450) were immunogenic, eliciting signiﬁcant proliferative T cell responses using lymph node cells from peptide-primed mice and production of IL-2 and IFN- g in recall assays in vitro. Both peptides induced experimental autoimmune thyroiditis upon direct challenge of CBA/J mice with peptide in CFA and by adoptive transfer of peptide-primed lymph node cells into naive recipient hosts, but neither peptide was characterized as dominant. The Journal of Immunology , 2013, 190: 1466–1471.
Landscape of the Tumor Microenvironment Tumor Cells Modulate the Immunological Effects of the Unfolded Protein Response in Tumor Stress Inside Out: Cell-Extrinsic

The unfolded protein response (UPR) is a eukaryotic cellular adaptive mechanism that functions to cope with stress of the endoplasmic reticulum (ER). Accumulating evidence demonstrates that the tumor microenvironment contains stressors that elicit a UPR, which has been demonstrated to be a cell-intrinsic mechanism crucial for tumorigenesis. In addition, the UPR is a source of proinﬂammatory signaling whose downstream mediators may hamper antitumor immunity. We discuss how the UPR may impair Ag presentation, which could result in defective T cell priming, also leading to tumor escape and growth. Further, we discuss the recent ﬁnding that ER stress and attendant proinﬂammation can be transmitted from ER-stressed tumor cells to myeloid cells. The ideas presented suggest that, in addition to being a cell-intrinsic mechanism of tumor survival, the tumor UPR can serve as a cell-extrinsic regulator of tumorigenesis by remodeling the immune response in the tumor microenvironment. The Journal of Immunology , 2011, 187: 4403–4409.
Increasing Evacuation Communication Through ICTs: An Agent-based Model Demonstrating Evacuation Practices and the Resulting Traffic Congestion in the Rush to the Road

Abstract Understanding evacuation practices and outcomes helps crisis and disaster personnel plan, manage, and rebuild during disasters. Yet the recent expansion in the number of information and communication technologies (ICTs) available to individuals and organizations has changed the speed and reach of evacuation-related messages. This study explores ICTs’ influences on evacuation decision-making and traffic congestion. Drawing from both social science and transportation science, we develop a model representative of individual decision making outcomes based on the amount of ICT use, evacuation sources, and the degree of evacuation urgency. We compare the evacuation responses when individuals receive both advance notice of evacuation (ANE) and urgent evacuation (UE) messages under conditions of no ICTs and prolific ICT use. Our findings from the scenarios when there is widespread ICT use reveal a shift in the evacuation time-scale, resulting in traffic congestion early in the evacuation cycle. The effects of this congestion in urgent situations are significantly worse than traffic congestion in the advance notice condition. Even under conditions where face-to-face communication is the only option, evacuations still occur, but at a slower rate, and there are virtually no traffic congestion issues. Our discussion elaborates on the theoretical contributions and focuses on how ICTs have changed evacuation behavior. Future research is needed to explore how to compensate for the rush to the road.
The Impact of Client and Therapist Religious Commitment on Psychotherapy in a University Counseling Center

The Impact of Client and Therapist Religious Commitment on Psychotherapy in a University Counseling Center Brodrick Thomas Brown Department of Psychology, BYU Doctor of Philosophy Religion is important to many Americans and the way they approach life, but psychologists are less likely than the general population to be religious. Because of this, it is important to not only know how religious commitment can influence clients’ outcome and experience in psychotherapy, but also how the level of match between client and therapist religious commitment might impact those variables. The current study was undertaken in order to investigate how client religious commitment impacts distress at the beginning and end of treatment, how therapist religious commitment impacts the use of religious/spiritual interventions in therapy, and whether the level of match between client and therapist religious commitment predicts client perception of therapy and/or outcome. Seven hundred and thirty individual therapy clients at a university counseling center completed measures of religious commitment, symptom distress, and concerns about therapy throughout their course of treatment. Forty-four therapists also completed a measure of religious commitment in addition to session-by-session checklists detailing what types of interventions they used in each appointment with participating clients. Client religious commitment was found to significantly predict lower initial distress (B = -0.77, p < 0.001, R2 = 0.07, 95% CI [-0.97, 0.57]) and lower distress at the end of therapy (B = -0.32, p = 0.001, R2 = 0.34, 95% CI [-0.51, 0.14]), and fewer concerns about therapy predicted better outcomes (B = 2.04, p < 0.001, R2 = 0.38, 95% CI [1.52, 2.52]). Contrary to the findings of previous research, therapist religious commitment did not predict use of religious/spiritual interventions in therapy (B = 0.05, p = 0.062, R2 = 0.09, 95% CI [-0.002, 0.11]). Finally, level of match between client and therapist religious commitment was not related to client concerns about therapy (B = -0.002, p = 0.161, 95% CI [-2.40, 9.57]) or client outcomes B = -0.014, p = 0.120, 95% CI [-0.03, 0.004]). Possible explanations and influencing factors are put forth and the findings are discussed in the context of a highly religious population.
Fatty Acids and Metabolomic Composition of Follicular Fluid Collected from Environments Associated with Good and Poor Oocyte Competence in Goats

In goats, embryo oocyte competence is affected by follicle size regardless the age of the females. In previous studies we have found differences in blastocyst development between oocytes coming of small (<3 mm) and large follicles (>3 mm) in prepubertal (1–2 months-old) goats. Oocyte competence and Follicular Fluid (FF) composition changes throughout follicle growth. The aim of this study was to analyze Fatty Acids (FAs) composition and metabolomic profiles of FF recovered from small and large follicles of prepubertal goats and follicles of adult goats. FAs were analyzed by chromatography and metabolites by 1H-Nuclear Magnetic Resonance (1H-NMR) Spectrometry. The results showed important differences between adult and prepubertal follicles: (a) the presence of α,β-glucose in adult and no detection in prepubertal; (b) lactate, -N-(CH3)3 groups and inositol were higher in prepubertal (c) the percentage of Linolenic Acid, Total Saturated Fatty Acids and n-3 PUFAs were higher in adults; and (d) the percentage of Linoleic Acid, total MUFAs, PUFAs, n-6 PUFAs and n-6 PUFAs: n-3 PUFAs ratio were higher in prepubertal goats. Not significant differences were found in follicle size of prepubertal goats, despite the differences in oocyte competence for in vitro embryo production.
Investigating the level of interdependency between the performance(s) of direct opponent(s) in professional football : a study on teams, positional units and individual players competing in the German Bundesliga

The purpose of this thesis is to investigate the levels of interdependency (simultaneity) between the performances of two direct opponents in professional football. More specifically, interdependency between performances is investigated at three different levels. Firstly, empirical analyses are conducted in order to assess the levels of interdependency between the performances of two teams in direct competition using team-game observations. Secondly, data on team formations and player starting positions within these formations is utilised in order to uniquely match individual players to a sole opponent on the field of play. Further empirical analyses are then conducted in order to investigate the levels of interdependency at this more isolated individual player level using player-game observations. Finally, an empirical investigation into the levels of interdependency between the performances of a positional unit (defence or attack) and their opposing team (as a collective) is conducted using positional unit-game observations. An exclusive and detailed data set ranging from the 2007-08 season to the 2010-11 season is utilised in order to estimate several production functions for teams, individual players and positional units competing in the German Bundesliga. The results in all empirical analyses confirm that the performance of the opponent is significant. At a team and positional unit level, no evidence is found to suggest that the performances of two direct opponents(s) are interdependent, however the results reveal that the recent past performances of the opponent(s) have a significant linear impact upon the performance of the subject. In particular, relative team form going in to a match is revealed to have a significant impact upon the performance of their opponent. At an individual player level, evidence is found to confirm that the performances of players in direct competition are interdependent thus supporting the sports economics theory of joint production. Specifically, the results reveal that the performances of defenders have a significant and negative impact upon the performances of their opposing attackers.
PENGARUH KEPEMILIKAN MANAJERIAL, KEPEMILIKAN PUBLIK, DAN KEPEMILIKAN ASING TERHADAP KINERJA PERUSAHAAN

The purpose of this research is to examine empirically the influence of managerial ownership, public ownership, foreign ownership toward firm performance. Population of this research is manufacturing industries category of consumer goods listed on Indonesia Stock Exchange during 2013-2017. Using purposive sampling technique, 160 manufacturing companies category of consumer goods listed on Indonesia Stock Exchange are selected as sample. The method of analysis was multiple linear regression. The result shows that there is positive effect between managerial ownership and foreign ownership with firm performance. While public ownership has no effect on firm performance.
PENGARUH PROFITABILITAS DAN LIKUIDITAS TERHADAP KEBIJAKAN DIVIDEN DENGAN RESIKO BISNIS SEBAGAI MODERASI

The purpose of this research is to analyze the effect of profitability and liquidity on dividend payout policy with business risk as moderating variable. Sample of 33 from 163 was selected from Indonesia Stock Exchange in 2015-2017. This research used Multiple linear regressionand Moderated Regression Analysis (MRA) to analyze the collected data on this research. The result of this research indicate that profitability and liquidity have a positive and significant influence to dividend payout policy. Business risk able to moderate there lationship between liquidity and dividend payout policy by weakening the relationship, but business risk not able moderate the relationship between profitability and dividend payout policy.