Miracle-dz/UniFAR-FTUs huggingface dataset:
Total versus partial adrenalectomy in bilateral pheochromocytoma – a systematic review and meta-analysis

Background In patients with bilateral pheochromocytoma, partial adrenalectomy offers the chance to preserve adrenal function and avoid the need for lifelong steroid supplementation. However, the risk of tumour recurrence raises questions about this procedure. The aim of our study was to compare partial and total adrenalectomy in bilateral pheochromocytoma through a systematic review with meta-analysis. Methods A systematic search was carried out using databases (MEDLINE, EMBASE, Scopus, Web of Science, CENTRAL) and registers of clinical trials (ClinicalTrials.gov, European Trials Register, WHO International Trials Registry Platform). This meta-analysis included studies up to July 2022 without language restrictions. A random effects model meta-analysis was performed to assess the risk of tumor recurrence, steroid dependence and morbidity in these patients. Results Twenty-five studies were included in the analysis involving 1444 patients. The relative risk (RR) of loss of adrenal hormone function during follow-up and the need for steroid therapy was 0.32 in patients after partial adrenalectomy: RR 0.32, 95% Confidence Interval (CI): 0.26-0.38, P < 0.00001, I2 = 21%. Patients undergoing partial adrenalectomy had a lower odds ratio (OR) for developing acute adrenal crisis: OR 0.3, 95% CI: 0.1-0.91, P=0.03, I2 = 0%. Partial adrenalectomy was associated with a higher risk of recurrence than total adrenalectomy: OR 3.72, 95% CI: 1.54-8.96, P=0.003, I2 = 28%. Conclusion Partial adrenalectomy for bilateral pheochromocytoma is a treatment that offers a chance of preserving adrenal hormonal function, but is associated with a higher risk of local tumor recurrence. There was no difference for the risk of metastasis and in overall mortality among the group with bilateral pheochromocytomas undergoing total or partial adrenalectomy. This study is in line with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and AMSTAR (A Measurement Tool to Assess Systematic Reviews) Guidelines (10, 11). Systematic review registration https://osf.io/zx3se.
Reversible relaxation at charged metal surfaces: An ab initio study

Results of an ab initio density functional theory study of atomic and electronic relaxation at electrically charged surfaces of Au suggest that the outward relaxation of the top layer at negative excess charge is driven by electrostatic forces on the surface atoms due to the incomplete screening of the external electric field. The relaxation amplitude agrees well with experiments on Au(111) in electrolyte. Electron redistribution between bonding and antibonding states in the plane containing the surface atoms may contribute to the charge response of the surface stress.
Engineless unmanned aerial vehicle propulsion by dynamic soaring

Dynamic soaring is a flight technique which extracts energy from wind gradients with the potential to power small unmanned aerial vehicles in maritime applications. Wind gradients of the required magnitude naturally occur at the air-sea interface due to friction between the waves and the moving air. Suitability of dynamic soaring as a means of propulsion requires clarification of the achievable flight performance and the likelihood of favorable winds. Optimal trajectories for minimal and maximal wind conditions are generated as well as trajectories for optimal cross-country travel. The flight model's differential flatness property is used to simplify the optimization problem. The likelihood of favorable winds is predicted based on long term weather statistics and knowledge of the minimal and maximal permissible wind strengths. Comparison of the likelihood of favorable winds for the wandering albatross and an unmanned aerial vehicle of similar size shows that the ability to fly close to the surface is a key factor governing dynamic soaring performance.
Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies

Purpose Recent scientific reports have revealed a close association between ferroptosis and the occurrence and development of osteoarthritis (OA). Nevertheless, the precise mechanisms by which ferroptosis influences OA and how to hobble OA progression by inhibiting chondrocyte ferroptosis have not yet been fully elucidated. This study aims to conduct a comprehensive systematic review (SR) to address these gaps. Methods Following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020, we conducted a comprehensive search of the Embase, Ovid, ProQuest, PubMed, Scopus, the Cochrane Library, and Web of Science databases to identify relevant studies that investigate the association between ferroptosis and chondrocytes in OA. Our search included studies published from the inception of these databases until January 31st, 2023. Only studies that met the predetermined quality criteria were included in this SR. Results In this comprehensive SR, a total of 21 studies that met the specified criteria were considered suitable and included in the current updated synthesis. The mechanisms underlying chondrocyte ferroptosis and its association with OA progression involve various biological phenomena, including mitochondrial dysfunction, dysregulated iron metabolism, oxidative stress, and crucial signaling pathways. Conclusion Ferroptosis in chondrocytes has opened an entirely new chapter for the investigation of OA, and targeted regulation of it is springing up as an attractive and promising therapeutic tactic for OA. Systematic review registration https://inplasy.com/inplasy-2023-3-0044/, identifier INPLASY202330044.
New formulas for interferometric crosstalk penalty as a function of total crosstalk power, number of crosstalk contributions and signal extinction ratio

Interferometric crosstalk, also called incoherent crosstalk, occurs when reception of a desired signal is disturbed by undesired crosstalk contributions having the same wavelength as the desired signal but independent amplitudes and phases. This crosstalk type is known to be among the most destructive phenomena in optical networks owing to its accumulative nature and strong impact on the transmission quality. New formulas state the crosstalk penalty as a function of the total crosstalk power, the number of contributions carrying this power and the signal extinction ratio. We consider both PIN and optically preamplified receivers. The authors know of no other published formulas which include the number of crosstalk contributions. The crosstalk penalty formulas are empirical, and they are based on a numerical model. This model is described briefly along with its experimental verification before the formulas themselves are presented.
The Biology of Stress Intolerance in Patients with Chronic Pain—State of the Art and Future Directions

Stress has been consistently linked to negative impacts on physical and mental health. More specifically, patients with chronic pain experience stress intolerance, which is an exacerbation or occurrence of symptoms in response to any type of stress. The pathophysiological mechanisms underlying this phenomenon remain unsolved. In this state-of-the-art paper, we summarised the role of the autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis, the two major stress response systems in stress intolerance. We provided insights into such mechanisms based on evidence from clinical studies in both patients with chronic pain, showing dysregulated stress systems, and healthy controls supported by preclinical studies, highlighting the link between these systems and symptoms of stress intolerance. Furthermore, we explored the possible regulating role for (epi)genetic mechanisms influencing the ANS and HPA axis. The link between stress and chronic pain has become an important area of research as it has the potential to inform the development of interventions to improve the quality of life for individuals living with chronic pain. As stress has become a prevalent concern in modern society, understanding the connection between stress, HPA axis, ANS, and chronic health conditions such as chronic pain is crucial to improve public health and well-being.
Origin of the low‐frequency sound absorption in sea water

Temperature‐jump measurements in sea water over the time domain 10−5 to 10−2 sec reveal a single relaxation of 1.5×10−4 sec at 9.7°C, which appears to correspond to the ∼ 1 kHz relaxation found from long‐range sound propagation. Laboratory measurements indicate the relaxation to originate from boron with the B(OH)3‐B(OH)4− equilibrium the likely relaxation process.
Algorithms for the total colorings of graphs

This thesis presents e cient algorithms for nding total colorings of graphs. A total coloring of a graph G is a coloring of all vertices and edges of G such that any two adjacent vertices receive di erent colors, any two adjacent edges receive di erent colors, and any edge receives a color di erent from the colors of its two ends. The total coloring problem asks to nd a total coloring of a given graph with the minimum number of colors. This problem is NP-hard and hence it is very unlikely that there is an e cient algorithm to solve the total coloring problem. On the other hand, it is known that many NP-hard problems, including the ordinary vertexand edgecoloring problems, can be e ciently solved for some restricted classes of graphs such as partial k-trees, series-parallel graphs, degenerate graphs, and so on. In this thesis, we deal with the total coloring problem for degenerate graphs, partial k-trees and other various classes of graphs. We show that any s-degenerate graph G has a total coloring with (G) + 1 colors if the maximum degree (G) is large, say (G) 4s + 3. Furthermore, we also show that one can e ciently nd such a total coloring. We also show that the total coloring problem can be solved in linear time for partial k-trees of bounded k, and give e cient algorithms to solve the total coloring problem for graphs in various classes with su ciently large maximum degrees. We also deal with the cost total coloring problem, which asks to nd a total coloring of a given graph with the minimum coloring cost with respect to a given color cost function.
Progress in the determination of the gravitational coefficient of the Earth

In most of the recent determinations of the geocentric gravitational coefficient (GM) of the Earth, the laser ranging data to the Lageos satellite have had the greatest influence on the solution. These data, however, have generally been processed with a small but significant error in one of the range corrections. In a new determination of GM using the corrected center-of-mass offset, a value of 398600.4415 km3/sec2 (including the mass of the atmosphere) has been obtained, with an estimated uncertainty (1 σ) of 0.0008 km3/sec2.
Under the sun or stars: how a dune ant (Hymenoptera: Formicidae) community is shaped along the day and night

Atlantic Forest (AF) is a threatened megadiverse biome distributed from north to south along the ocean of South America and is considered a hotspot of biodiversity. Currently, over 3000 ant taxa are known to occur in AF ecosystems, and many more are expected but may never be acknowledged. The patterns and processes structuring AF ant communities are not well known, urging such studies. Temperature is a fundamental environmental condition that modulates ant species occurrences at different local and regional scales. Global warming may deeply impact species occurrence, dynamics and interactions, and efforts to amplify our understanding of AF biodiversity are urgent. Ants are widely distributed in the dunes, and many species are sensitive to local changes in temperature as some species are considered thermophilic. In open areas such as dunes, the temperature varies considerably over 24 h, with great changes mainly between day and night. In this study, we sought to answer whether the foredune ant community of the Restinga, one of the habitats of the AF, is structured by temperature from day and night. For this, we tested the following hypotheses: (i) temperature influences ant diversity; (ii) in warmer periods, there is a decrease in richness, with an increase in abundance; and (iii) ant species composition varies throughout the day and, consequently, at different temperatures. We arbitrarily drew a parallel transect to the ocean composed of 15 pitfall trap units spaced every 30 m. Traps were changed in five sampling periods: T1 (9:10–13:10 h), T2 (13:40–18:40 h), T3 (19:00–23:00 h), T4 (23:00–03:00 h) and T5 (03:00–07:00 h). In each period, we recorded the ambient temperature and relative humidity. We recovered 11 ant species on the foredunes. Our results showed that the richness and abundance of ants in the daytime period was higher than in the night‐time period, suggesting that temperature positively affected these two parameters of the studied community. The species composition also changed over the sampling periods. Considering that our aim was to describe the species diversity across 24 h of sampling, this ‘quick‐shot’ of the ant community allowed us to determine that temperature and humidity shape their occurrence and activity. These results indicate that there is an interplay between these factors that are correlated and play an important role in structuring ant communities in Restinga foredunes.
Reliable 
H
∞ Filtering for Mixed Time‐Delay Systems with Stochastic Nonlinearities and Multiplicative Noises

This paper investigates the reliable H∞ filtering problem for a class of mixed time‐delay systems with stochastic nonlinearities and multiplicative noises. The mixed delays comprise both discrete time‐varying and distributed delays. The stochastic nonlinearities in the form of statistical means cover several well‐studied nonlinear functions. The multiplicative disturbances are in the form of a scalar Gaussian white noise with unit variance. Furthermore, the failures of sensors are quantified by a variable varying in a given interval. In the presence of mixed delays, stochastic nonlinearities, and multiplicative noises, sufficient conditions for the existence of a reliable H ∞ filter are derived, such that the filtering error dynamics is asymptotically mean‐square stable and also achieves a guaranteed H ∞ performance level. Then, a linear matrix inequality (LMI) approach for designing such a reliable H ∞ filter is presented. Finally, a numerical example is provided to illustrate the effectiveness of the developed theoretical results.
The effect of lifestyle modification on metabolic, anthropometric parameters and hirsutism score in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a hormonal disorder that affects women of reproductive age. It is characterised by several clinical signs and symptoms, including hyperandrogenism, ovarian dysfunction, and chronic anovulation. Obesity and hormonal imbalances can be reduced in PCOS by modifying lifestyle habits. The effects of lifestyle changes on PCOS were investigated, and it was found that consuming less fat and engaging in physical activity reduced metabolic disturbances. The purpose of this study was to examine the effects of lifestyle modifications on metabolic parameters, anthropometric parameters, and the hirsutism score as they relate to the pathogenesis of PCOS. This study involved a total of 10 patients diagnosed with PCOS at the Sultan Agung Semarang Islamic Hospital. Blood glucose, triglycerides, HDL (high density lipoprotein), blood pressure, waist circumference, hirsutism score, and vital sign data related to PCOS were measured before and after a 4-month treatment. PCOS patients' fasting blood sugar levels, triglycerides (TG), high density lipoprotein (HDL), hirsutism scores, blood pressure (systolic and diastolic), and waist circumference averaged 92, 60; 48.10; 96.90; 10.5; 121.5/77; 86.80, respectively, at baseline (pretreatment). After four months of treatment, the average levels of fasting blood sugar, triglycerides, high-density lipoproteins, blood pressure (systolic and diastolic), hirsutism scores, and waist circumference were 108.7, 50, 99.8, 7, 122.3, 82.7, and 87.50, respectively. Changes in lifestyle led to significant variations in fasting blood sugar levels as a metabolic parameter and hirsutism scores, but not in triglycerides, high-density lipoprotein, waist circumference, or blood pressure.
Osteochondral allograft transplantation for treating medial femoral condyle subchondral bone cyst in a 14-year-old standardbred horse: a case report

Allograft arthroplasty is a promising cartilage-resurfacing technique. A 14-year-old horse was diagnosed with a medial femoral condyle subchondral bone cyst. Allografts were harvested from a young donor animal and implanted to fill the cyst cavity. A visual assessment of the surgical site was possible during follow-up arthroscopy. In addition to a desirable gliding surface and a good adaptation of the grafts, fibrillation of the cranial ligament of the medial meniscus was noted and debrided. The recipient horse became sound four months after follow-up surgery with a high level of owner satisfaction. In conclusion allograft transplantation is a promising technique for treating subchondral bone cysts.
On the Estimation of Trends in Annual Rainfall Using Paired Gauge Observations

Abstract A method was recently proposed for evaluating the impact of a perturbation, such as air pollution or urbanization, on the precipitation at a location by calculating the ratio between the precipitation at the perturbed location and that at a location believed to be unperturbed. However, this method may be inappropriate because of the high degree of variability of precipitation at each of the stations. To explore the validity of this approach, noisy annual rainfall records are generated numerically in an upwind, unperturbed station and in a downwind, perturbed station, and the time series of ratio between the annual rainfalls in the two stations is analyzed. The noisy rainfall records are 50 yr long, and the imposed trend for the downwind, perturbed station is −2 mm yr−1 while at the upwind station the variations in annual rainfall are purely noisy. Many pairs of noisy rainfall records are numerically generated (each pair constitutes an experiment), and in every experiment the slope of the linear b.
Evaluation of the Optimum Interpolation and Nudging Techniques for Soil Moisture Analysis Using FIFE Data

Abstract Initialization of land surface prognostic variables is a crucial issue for short- and medium-range forecasting as well as at seasonal timescales. In this study, two sequential soil moisture analysis schemes are tested, both based on the comparison between observed and predicted 2-m parameters: the nudging technique used operationally at the European Centre for Medium-Range Weather Forecasts (ECMWF) and the optimum interpolation technique proposed by J. F. Mahfouf and used operationally at Meteo-France. Both techniques compute the soil moisture increments as a linear function of analysis increments of 2-m parameters (specific humidity at ECMWF, temperature and relative humidity at Meteo-France). Following the preliminary study by Y. Hu et al., the optimum interpolation technique has been adapted to the four soil-level ECMWF land surface scheme. Both methods are tested in the ECMWF single column model, which has been run for 4 months in 1987 at a grid point close to the location of the First Intern.
Effect of viral respiratory vaccine treatment on performance, health and carcass traits of auction-origin feeder steers.

A total of 3,147 auction-origin steers were used to compare the effects of three different virus vaccines on performance, health, carcass traits and economic return in a commercial feedlot. Vaccine products compared were PyramidÂ® 5 (Fort Dodge Animal Health, Overland Park, KS), Bovi-Shield GoldÂ® 5 (Pfizer Animal Health, New York, NY) and Bovi-Shield GoldÂ® IBR-BVD. Steers vaccinated with Pyramid 5 (PYR5) vaccine had 3.8% ( P =0.09) better feed conversion than those vaccinated with Bovi-Shield Gold IBR-BVD (BOV3) vaccine when calculated on a live-weight basis, but similar to steers in the Bovi-Shield GoldÂ® 5 (BOV5) group. On a carcass-weight basis, feed conversion was 3.6% better ( P =0.09) in the PYR5 treatment group compared to steers in the other treatment groups. No differences ( P >;0.10) in carcass traits were noted among the three treatment groups. The morbidity rate due to bovine respiratory disease was 11% lower ( P =0.09) in steers vaccinated with PYR5 compared to those vaccinated with BOV5, and the relapse rate was 22% lower ( P =0.04). Combined treatment and railer (culling) costs were $8.81/head and $7.56/head lower in the PYR5 group than in the BOV5 and BOV3 steers, respectively. Mortality costs did not differ among treatments ( P =0.52).
Three-dimensional flow structure and aerodynamic loading on a revolving wing

A numerical study is conducted to examine the vortex structure and aerodynamic loading on a revolving wing in quiescent flow. A high-fidelity, implicit large eddy simulation technique is employed to simulate a revolving wing configuration consisting of a single, aspect-ratio-one rectangular plate extended out a distance of half a chord from the rotational axis at a fixed angle relative to the axis. Shortly after the onset of the motion, the rotating wing generates a coherent vortex system along the leading-edge. This vortex system remains attached throughout the motion for the range of Reynolds numbers explored, despite the unsteadiness and vortex breakdown observed at higher Reynolds numbers. The average and instantaneous wing loading also increases with Reynolds number. At a fixed Reynolds number, the attachment of the leading-edge vortex is also shown to be insensitive to the geometric angle of the wing. Additionally, the flow structure and forcing generated by a purely translating wing is investigated.
Phenolic Compound Production Increased In Vitro Regenerated Cichorium intybus L.

Chicory (Cichorium intybus L.) is a low-height perennial or biennial herb from the family of Asteraceae. Investigation of different in vitro regeneration strategies of Cichorium intybus and increasing the number of secondary metabolites in vitro regenerated plant samples were the aims of the research. Callus and plant regenerations were achieved in basal plant growth media supplemented with plant growth regulators (PGRs). Whole plant regeneration was carried out by direct organogenesis from leaf explant in Murashige and Skoog (MS) and B5 media supplemented with naphthalene acetic (NAA) acid and indole-3-butyric acid (IBA). The highest callus quantity was produced in MS medium supplemented with indole-3-acetic acid (IAA) and benzyl amino purine (BAP). The combination and concentrations of PGRs used in MS and B5 media not only provided root and shoot formation with callus, but also caused a change in the amounts of phenolic components. In addition, some PGRs used caused an increase in the number of phenolic compounds in callus and shoots developed from the leaf explant. When plants that grow in vitro and in vivo are compared with each other, it has been determined that plants grown in vivo contain higher amounts of some phenolic compounds. In vivo and in vitro samples were extracted in ethanol/water (80:20 v/v). The analysis of phenolic compounds (caftaric, chicoric, and chlorogenic acids and esculin) were performed in high-performance liquid chromatography (HPLC) and inulin was in UV spectrophotometry. The caftaric and chlorogenic acids and inulin concentrations were higher in vivo samples than that in vitro. Contrarily, esculin, and chicoric acid concentrations were higher in the in vitro regenerated samples. The higher concentration of valuable compounds in the in vitro regenerated samples, especially in callus tissue, gives hope for large-scale production of secondary metabolites under laboratory conditions.