Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative study of tamsulosin versus tadalafil in benign prostatic hyperplasia patients with lower urinary tract symptoms. A prospective randomized study

Introduction: Benign prostatic hyperplasia (BPH) is one of the common causes of lower urinary tract symptoms (LUTS) in aging men. Men with LUTS have a higher incidence of erectile dysfunction (ED), and LUTS themselves represent an independent risk factor for ED, triggering a significant negative impact on quality of life. Materials and Methods: A total of 92 patients were randomly assigned to two groups. Groups I and II had 45 and 47 patients, two patients from Group I and three patients from Group II did not follow and were excluded from the study. Patients in Group I received 0.4 mg of tamsulosin and Group II patients received 5 mg tadalafil. Patients were assessed at baseline, 3 months, and at 6 months after receiving treatment. Treatment efficacy was measured by a change in Qmax, post void residual urine (PVR), International Prostate Symptom Score (IPSS), and Sexual Health Inventory for Men (SHIM) score at 3 months and 6 months. Results: Baseline parameters between the two groups were similar. Mean Qmax improved by 7 ml/s at 3 months to 9.44 ml/s at 6 months in Group I versus 4.73 ml/s at 3 months to 6.46 ml/s at 6 months in Group II (P = 0.739). Mean PVRU decreased by 35.53 ml at 3 months to 47.23 ml at 6 months in Group I versus 44.98 at 3 months to 58.28 ml at 6 months in Group II (P = 0.102). IPSS score improved by 4.24 points at 3 months to 7.22 points at 6 months in Group I versus 4 points at 3 months to 5.02 points at 6 months in Group II (P = 0.336). SHIM score improved by 0.7 points 16.2 at 3 months to 0.8 points at 6 months in Group I versus 6.12 points at 3 months to 6.3 points at 6 months (P < 0.001). Conclusion: When both groups were compared, tadalafil showed statistically similar improvements in Qmax, PVRU, and IPSS score, but statistically significant improvement was observed with tadalafil in SHIM score compared with tamsulosin in treating LUTS secondary to BPH. Our study provides evidence that once daily tadalafil 5 mg is well tolerated and can be considered for the treatment of LUTS secondary to BPH especially in patient with ED.
Influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: A 7-year single-center experience

Objective: The objective of the study is to describe the perioperative outcomes, disease-specific, and overall survival status in patients diagnosed with renal cell carcinoma with inferior vena cava (IVC) tumor thrombus. Patients and Methods: We did a retrospective analysis of all patients who underwent radical nephrectomy along with IVC thrombectomy from the year 2013 to 2020. Mayo's classification was used to stratify the level of IVC thrombus. Demographic, perioperative, histopathology data, complications, and survival status were analyzed. Results: Total number of patients included in the study was 39, (Male: Female = 84.6%: 15.4%). Median age of patients was 58 (interquartile range [IQR] 50–63) years. Median size of renal tumor (in cms) was 9.5 (IQR 7.5–12), 8 (IQR 7–11.5), 8.5 (IQR 7–11.75), and 11 (IQR 9.5–11) (P = 0.998) in level 1,2,3, and 4 tumors, respectively. Clear cell variant was seen in 32 patients (82%) with R0 resection in 17 patients. Twelve patients (30.7%) had systemic metastasis on presentation. The overall mean survival time was 66.4 months with 95% confidence interval (CI) (52.4–80.5 months). Mean recurrence-free survival is 76 months with (63–90) CI of 95%. Mean survival in patients who presented with metastasis is 47 months with 95% CI (52.4–80.5). Perioperative mortality rate was 5.12% in this study. Conclusion: The tumor size does not have an influence on the progression of tumor thrombus into IVC. Significant difference in survival was observed between different levels of thrombus with high mortality in level four tumors.
New Findings about Liver Kupffer Cells/Macrophages, B Cells and their Functions

Furthermore, we found that CD32/68 cells produce MCP-1 after they phagocytose clod-lip and before undergoing apoptosis, and MCP-1 leads to the accumulation of CD11b cells in the liver from the periphery and bone marrow, and probably stimulates their functions (TNF/IL-12 production) [2]. Therefore, mice depleted of CD32/68 cells in the liver by clod-lip administration became extremely susceptible to bacterial infections, whereas these mice unexpectedly became resistant to liver metastatic tumors, and lived longer after intra-splenic EL-4 tumor cell injection than control mice, because the accumulated and activated CD11b Kupffer cells/macrophages produced IL-12, which stimulates liver NK cells and NKT cells to produce IFN-γ and may augment the liver’s antitumor immunity [2] (Figure 1). CD32/68 cells, but not CD11b cells, express other markers specific for tissue macrophages, such as MerTK and CD64, which are also expressed by spleen CD11b-(minus) resident macrophages [2]. Thus, the mature CD68 cells in the liver are resident macrophages (Kupffer cells), while the F4/80+CD11b cells in the liver are recruited Kupffer cells/macrophages from bone marrow, and these cells are quite different from each other in terms of the their functions and development [2]. These features of liver Kupffer cells (the subsets and their functions)also apply to human liver Kupffer cells [2].
Estimating Retransmission Timeouts in IP-Based Transport Protocols

—This paper analyzes the algorithm used for estimating retransmission timeouts in connection-oriented IP-based transport protocols, such as the Transmission Control Protocol (TCP) and the Stream Control Transmission Protocol (SCTP). The estimation algorithm uses historical values of the round-trip time to estimate future round-trip delays, and so creates a maximum waiting time before triggering retransmission attempts. The purpose of the analysis is to question / validate some of the fundamental assumptions used in the estimation algorithm. The conclusion of the analysis is that the algorithm is somewhat mismatched to the application area. Alternative algorithms are discussed, and potential modiﬁcations are presented.
Critical Care Intern Nurses Stressors and Their Management Strategies

: Nursing has been identified as a stressful occupation. The transition from a student to new graduate can be stressful and ''is a reality shock''. Novice nurses have specific stressors that might be different from other nurses and today they feel that they are most frustrated by the lack of care and concern of others. Therefore, this study was conducted. Aim of the study: to identify the critical care intern nurse stressors and their management strategies. Design: descriptive research design was used to conduct this study. Settings: Intensive care units of Alexandria Main University Hospital (Casualty Care Unit and General Intensive Care Unit) and health insurance hospital. Methods: The subject of the study consisted of all critical care intern nurses working in all above mentioned settings at the study time (80 nurses). Two tools were used to collect the data: Tool I : intern nurse stressors questionnaire and Tool II: intern nurse stress management questionnaire tool. Results: This result indicated that intern nurses perceived high to extreme level of stress. Among the three stress subscales; work management was perceived as the extreme level of stress followed by interpersonal relationships, and workload. Self-control was the most common management strategy of stress used by intern nurses. Conclusion: high stress is prevalent among intern nurses. Major stressors of interns were related to work management, followed by interpersonal relationship and workload. Intern nurses are coping with their stressors by self-control and cognitive strategies.
Single-cell RNA sequencing reveals the diversity of the immunological landscape following CNS infection 3

Intracranial (i.c.) infection of susceptible C57BL/6 mice with the neurotropic JHM strain of mouse hepatitis 23 virus (JHMV) (a member of the Coronaviridae family) results in acute encephalomyelitis and viral persistence 24 associated with an immune-mediated demyelinating disease. The present study was undertaken to better 25 understand the molecular pathways evoked during innate and adaptive immune responses as well as the chronic 26 demyelinating stage of disease in response to JHMV infection of the central nervous system (CNS). Using 27 single cell RNA sequencing analysis (scRNAseq) on flow-sorted CD45-positive cells (CD45 + ) enriched from 28 brains and spinal cords of experimental mice, we demonstrate the heterogeneity of the immune response as 29 determined by unique molecular signatures and pathways involved in effective anti-viral host defense. 30 Furthermore, we identify potential genes involved in contributing to demyelination as well as remyelination 31 being expressed by both microglia and macrophages. Collectively, these findings emphasize the diversity of the 32 immune response and molecular networks at defined stages following viral infection of the CNS. repair offer for interventional therapy 55, 74-77).
Effect of Environmental Parameters on the Reproduction of the White Mullet (Mugil curema, Valenciennes, 1836) in the Saloum Delta (Senegal)

Mugil curema , known as white mullet, was one of the fish species encountered in the fisheries landings of the Saloum Delta. In this study, the morphometric parameters and the reproductive biology of this species were studied as well as the influence of environmental parameters on its reproduction. Experimental fisheries were carried out monthly in the Saloum Delta. The fish were caught using surface sexual maturity. Out of a total of 406 individuals sampled in the Saloum Delta, 306 females and 100 males were identified, no individuals of undetermined sex were obtained. The sex ratio was globally in favor of females. Individuals in this study ranged in size from 102 to 385 mm and weight from 34.9 to 395 g. The allometric coefficient b was equal to 2.40 and indicated a negative allometry. The exploitation of the monthly IGS results indicated that reproduction was in April, May and June. The size at first sexual maturity indicated that the males matured at a size of 220 mm, lower than that of the females 226 mm.
Menstrual Cycle and Physical Effort Menstrual Cycle and Physical Effort

In addition to affecting the sexual organs in women, ovarian hormones have a wide impact on processes related to metabolism, water and electrolyte balance, thermoregula tion, and redox balance. Differences in the estradiol and progesterone concentrations during the follicular and luteal phases, as well as the increase in the concentration of these hormones under the influence of physical exercise, may cause a different course of exercise response in women depending on the phase of menstrual cycle. Estrogens affect the metabolism of women by reducing the rate of gluconeogenesis and glycogenolysis and, at the same time, by increasing the share of lipids in covering energy requirements. Progesterone affects respiratory system parameters causing, among others, an increase in pulmonary ventilation. The resultant antagonistic action of progesterone and estra diol is the effect on thermoregulatory mechanisms. Increased estradiol concentration at the low progesterone concentration level causes water and electrolyte retention. In turn, an increased level of progesterone leads to loss of water and sodium, causing a decrease in the volume of plasma during the postovulatory phase of the menstrual cycle. The pro cesses described above are related to metabolic changes affecting the ability to perform physical efforts.
Global branching laws by global Okounkov bodies

Let $G'$ be a complex semisimple group, and let $G \subseteq G'$ be a semisimple subgroup. We show that the branching cone of the pair $(G, G')$, which (asymptotically) parametrizes all pairs $(W, V)$ of irreducible finite-dimensional $G$-representations $W$ which occur as subrepresentations of a finite-dimensional irreducible $G'$-representation $V$, can be identified with the pseudo-effective cone, $\overline{\mbox{Eff}}(Y)$, of some GIT quotient $Y$ of the flag variety of the group $G \times G'$. Moreover, we prove that the quotient $Y$ is a Mori dream space. As a consequence, the global Okounkov body $\Delta(Y)$ of $Y$, with respect to some admissible flag of subvarieties of $Y$, is fibred over the branching cone of $(G, G')$, and the fibre $\Delta(Y)_{(W, V)}$ over a point $(W, V)$ carries information about (the asymptotics of) the multiplicity of $W$ in $V$. Using the global Okounkov body $\Delta(Y)$, we easily derive a multi-dimensional generalization of Okounkov's result about the log-concavity of asymptotic multiplicities.
A DATING APPROACH OF A REFUNDABLE WOODEN EGYPTIAN COFFIN LID

In the Police seizures museum, Citadel, Egypt, there are large numbers of the refundable objects, a lot of them undated. So, this study focuses on dating a fragment of a refundable wooden Egyptian coffin lid based on its technology and typology through multi-analytical techniques. The coffin lid was examined by visual investigation, optical microscope, Scanning electron microscope (SEM) and EDAX, FTIR spectroscopy and X-ray diffraction. These investigations were carried on to identify the used wood, preparation layers, pigments and modern interventions. With the use of this information we tried to date this piece in accordance to the previous studies concerned with the coffin construction techniques through ages. The results showed that the stratigraphy of this coffin lid corresponds to the stratigraphy of the yellow coffins, which appeared at the 18th Dynasty (1575-1307 BC) and ending suddenly at the first half of twenty-two Dynasty (~945-840 BC), according to general similarities of shape, structure and coloring
(cid:1) IIb (cid:2) 3 biogenesis is controlled by engagement of (cid:1) IIb in the calnexin cycle via the N15-linked glycan

Although much is known about (cid:1) IIb (cid:2) 3 structure and function, relatively little is understood about its biogenesis. Thus, we studied the kinetics of pro- (cid:1) IIb produc-tionanddegradation,focusingonwhether proteasomal degradation or the calnexin cycle participates in these processes. In pulse-chase analyses, the time to half-disappearance of pro- (cid:1) IIb (t1/2) was the same in (1) HEK293 cells transfected with (a) (cid:1) IIb plus (cid:2) 3, (b) (cid:1) IIb alone, (c) mutant V298F (cid:1) IIb plus (cid:2) 3, or (d) I374T (cid:1) IIb plus (cid:2) 3; and (2) murine wild-type and (cid:2) 3-null megakaryocytes. Inhibition of the proteasome prolonged the t1/2 values in both HEK293 cells and murine megakaryocytes. Calnexin coprecipitated with (cid:1) IIb from HEK293 cells transfected with (cid:1) IIb alone, (cid:1) IIb plus (cid:2) 3, and V298F (cid:1) IIb plus (cid:2) 3. For proteins in the calnexin cycle, removal of the terminal mannose residue of the middle branch of the core N-linked glycan results in degradation. Inhibition of the enzyme that removes this mannose residue prevented pro- (cid:1) IIb degradation in (cid:2) 3-null murine megakaryocytes. (cid:1) IIb contains a conserved glycosylation consensus sequence at N15, and an N15Q mutation prevented pro- (cid:1) IIb maturation, complex formation, and degradation. Our ﬁndings suggest that pro- (cid:1) IIb engages the calnexin cycle via the N15 glycan and that failure of pro- (cid:1) IIb to complex normally with (cid:2) 3 results in proteasomal degradation. (Blood. 2006;107:2713-2719)
Single-Nucleotide-Polymorphism Typing and Genetic Relationships of Salmonella enterica Serovar Typhi Isolates (cid:1) †

Salmonella enterica serovar Typhi is a clone with a low level of variation. We developed a molecular typing method for serovar Typhi using 38 genome-wide single-nucleotide polymorphisms (SNPs) as markers detected by PCR-restriction enzyme digestion. The 73 worldwide serovar Typhi isolates studied were separated into 23 SNP proﬁles and four distinct genetic groups. Serovar Typhi isolates expressing the unique ﬂagellar antigen z66 were found to cluster together and branch off from the ancestral group, suggesting that serovar Typhi was initially monophasic with only an H1 antigen and subsequently gained the z66 antigen. Typing using the 38 SNPs gave a discriminatory power of 0.87, and a minimum of 16 SNPs may be used to achieve the same level of differentiation. The SNP typing method we developed will be a valuable tool for global epidemiology studies of serovar Typhi. Typhoid fever, a serious systemic disease, is caused by Salmonella enterica serovar Typhi and is endemic in countries where problems of hygiene and sanitation remain unresolved.
PENETRATION OF MANNITOL INTO POTATO DISCS 1

This paper deals with a problem which, while minor in itself, may nevertheless loom large when interpreting experiments on the relationship between osmotic values and cell enlargement. In 1953 Bonner et al (1) published some experiments on the uptake of water by slices of artichoke tuber (Helianthus tuberosus L.) which showed that the increase in respiration of this tissue caused by auxin was very much less when in hypertonic solutions of mannitol than when in water. However, Burstr6m (6) gave reasons for believing that the value for the osmotic pressure of the tuber tissue at incipient plasmolysis, given by Bonner et al as 0.12 M, was too low, and reported a number of measurements which yielded values of 0.4 M and up. Further, while Burstrom's data undoubtedly established that the osmotic pressure of artichoke tissue was higher than had been thought, the data also brought out another, and a surprising, fact. This unexpected observation, which could not be explained at the time, was that when the tuber slices had been immersed in mannitol for 54 hours, the osmotic pressure at incipient plasmolysis had increased to extremely high values, in one case reaching 1 M and, in general, attaining values nearly proportional to the mannitol concentration used. This great rise could mean one of two things; either mannitol steadily enters the cells, or else the exposure to mannitol causes liberation within the cells of some osmotically active material. Either of these two phenomena would have a most important bearing on studies of the water uptake of tuber slices which, since the pioneer work of Reinders (12), have proven to be useful material for the study of auxin action. The result was of special interest to us since we had noted in several experiments with mannitol that potato discs, after their growth had been inhibited by high external osmotic pressure, tended to show a partial recovery. Examples of this will be shown below. More important, it was demonstrated (see fig 14 of ref 13) that if water uptake in auxin were restricted for 24 hours by adding 0.3 M mannitol, then on return for 4 hours to plain auxin the sections rapidly took up extra water and essentially recovered all the ground lost during the inhibition period. This was interpreted as evidence that auxin had been continuously modifying the cell walls at about the same rate as though the mannitol had not been present, i.e., that auxin action on cell walls had been uninterrupted.
Characterization of Mutations in the metY - nusA - infB Operon That Suppress the Slow Growth of a (cid:2) rimM Mutant

The RimM protein in Escherichia coli is associated with free 30S ribosomal subunits but not with 70S ribosomes. A (cid:1) rimM mutant shows a sevenfold-reduced growth rate and a reduced translational efﬁciency, probably as a result of aberrant assembly of the ribosomal 30S subunits. The slow growth and translational deﬁciency can be partially suppressed by increased synthesis of the ribosome binding factor RbfA. Here, we have identiﬁed 14 chromosomal suppressor mutations that increase the growth rate of a (cid:1) rimM mutant by increasing the expression of rbfA . Nine of these mutations were in the nusA gene, which is located upstream from rbfA in the metY-nusA-infB operon; three mutations deleted the transcriptional terminator between infB and rbfA ; one was an insertion of IS 2 in infB , creating a new promoter for rbfA ; and one was a duplication, placing a second copy of rbfA downstream from a promoter for the yhbM gene. Two of the nusA mutations were identical, while another mutation ( nusA98 ) was identical to a previously isolated mutation, nusA11 , shown to decrease termination of transcription. The different nusA mutations were found to increase the expression of rbfA by increasing the read-through of two internal transcriptional terminators located just downstream from the metY gene and that of the internal terminator preceding rbfA . Induced expression of the nusA (cid:2)
Anti-neutrophil cytoplasmic antibodies predate symptom onset of ANCA-associated vasculitis. A case-control study Journal of Autoimmunity

Objectives: Anti-neutrophil cytoplasmic autoantibodies [ANCA) are important for diagnosis of ANCA-associated vasculitides (AAV). The timing of antibody development is not well established. To investigate the development of proteinase 3 (PR3)- and myeloperoxidase (MPO)-ANCA, blood samples collected before onset of symptoms of AAV were analysed. Methods: To identify AAV patients with blood samples predating symptoms, the National Patient Register and Cause of Death register were scrutinized for ICD codes for AAV and linked to the registers of five biobanks. Diagnoses of AAV and
Self-Construal and its relationship with Individualism Collectivism in Egypt

This article studied the authenticity and validity of the Egyptian Version of Singelis’s (1994) 30-item Self-Construal Scale (SCS). The Participants in this study consisted of 419 undergraduate students where they completed (SCS) scale and the Individualism-Collectivism (IND-COL) Scale. Results of factor analysis showed two interpretations: Independent and Interdependent Self Construal in Egypt environment. The internal consistency of the Inter. and Ind. SC subscales were found to be 0.89, 0.27 respectively. The Cronbach alphas of the Inter. and Ind. SC subscales were found to be 0.83, and 0.46 respectively. The Inter. SC Positively related to Collectivism but no significant relationship was found between Ind. SC and Individualism. Possible culture limitations of Self-Construal are discussed.
An HﬂX-Type GTPase from Sulfolobus solfataricus Binds to the 50S Ribosomal Subunit in All Nucleotide-Bound States (cid:1)

HﬂX GTPases are found in all three domains of life, the Bacteria , Archaea , and Eukarya . HﬂX from Escherichia coli has been shown to bind to the 50S ribosomal subunit in a nucleotide-dependent manner, and this interaction strongly stimulates its GTPase activity. We recently determined the structure of an HﬂX ortholog from the archaeon Sulfolobus solfataricus (SsoHﬂX). It revealed the presence of a novel HﬂX domain that might function in RNA binding and is linked to a canonical G domain. This domain arrangement is common to all archaeal, bacterial, and eukaryotic HﬂX GTPases. This paper shows that the archaeal SsoHﬂX, like its bacterial orthologs, binds to the 50S ribosomal subunit. This interaction does not depend on the presence of guanine nucleotides. The HﬂX domain is sufﬁcient for ribosome interaction. Binding appears to be restricted to free 50S ribosomal subunits and does not occur with 70S ribosomes engaged in translation. The ﬁngerprint 1 H- 15 N heteronuclear correlation nuclear magnetic resonance (NMR) spectrum of SsoHﬂX reveals a large number of well-resolved resonances that are broadened upon binding to the 50S ribosomal subunit. The GTPase activity of SsoHﬂX is stimulated by crude fractions of 50S ribosomal subunits, but this effect is lost with further high-salt puriﬁcation of the 50S ribosomal subunits, suggesting that the stimulation depends on an extrinsic factor bound to the 50S ribosomal subunit. Our results reveal common properties but also marked differences between archaeal and bacterial HﬂX proteins.