Miracle-dz/UniFAR-FTUs huggingface dataset:
Dual EGFR and ABL Tyrosine Kinase Inhibitor Treatment in a Patient with Concomitant EGFR-Mutated Lung Adenocarcinoma and BCR-ABL1-Positive CML

Tyrosine kinase inhibitor (TKI) combination is expected to increase in the era of precision medicine. TKI combination may be required to treat double primary cancers, each having a targetable gene, or to treat a single malignancy with multiple targetable genes. Here, we demonstrate the first report of dual EGFR and ABL TKI treatment in a patient with concomitant EGFR-mutated lung adenocarcinoma and BCR-ABL1-positive chronic myeloid leukemia (CML). A 60-year-old man with an 8-year history of CML was diagnosed as advanced EGFR-mutated lung adenocarcinoma. Complete molecular response of CML had been achieved by imatinib, and ABL-TKI had been switched to nilotinib four years previously due to muscle cramps. We discontinued nilotinib and started afatinib. Although partial response of lung adenocarcinoma was achieved, cytogenetic relapse of CML was observed following nilotinib discontinuation. We applied the previously described framework of cytochrome P450 3A4-mediated oral drug-drug interactions and selected gefitinib and nilotinib to treat both malignancies. We effectively and safely administered this combination for seven months. The present report is the first to demonstrate the safety and efficacy of dual EGFR and ABL TKI treatment in a patient with concomitant EGFR-mutated lung adenocarcinoma and CML.
Fire hazard modulation by long-term dynamics in land cover and dominant forest type in eastern and central Europe

Abstract. Wildfire occurrence is influenced by climate, vegetation and human activities. A key challenge for understanding the risk of fires is quantifying the mediating effect of vegetation on fire regimes. Here, we explore the relative importance of Holocene land cover, land use, dominant functional forest type, and climate dynamics on biomass burning in temperate and boreo-nemoral regions of central and eastern Europe over the past 12 kyr. We used an extensive data set of Holocene pollen and sedimentary charcoal records, in combination with climate simulations and statistical modelling. Biomass burning was highest during the early Holocene and lowest during the mid-Holocene in all three ecoregions (Atlantic, continental and boreo-nemoral) but was more spatially variable over the past 3–4 kyr. Although climate explained a significant variance in biomass burning during the early Holocene, tree cover was consistently the highest predictor of past biomass burning over the past 8 kyr. In temperate forests, biomass burning was high at ∼45 % tree cover and decreased to a minimum at between 60 % and 70 % tree cover. In needleleaf-dominated forests, biomass burning was highest at ∼ 60 %–65 % tree cover and steeply declined at >65 % tree cover. Biomass burning also increased when arable lands and grasslands reached ∼ 15 %–20 %, although this relationship was variable depending on land use practice via ignition sources, fuel type and quantities. Higher tree cover reduced the amount of solar radiation reaching the forest floor and could provide moister, more wind-protected microclimates underneath canopies, thereby decreasing fuel flammability. Tree cover at which biomass burning increased appears to be driven by warmer and drier summer conditions during the early Holocene and by increasing human influence on land cover during the late Holocene. We suggest that long-term fire hazard may be effectively reduced through land cover management, given that land cover has controlled fire regimes under the dynamic climates of the Holocene.
Relative Amounts of Eicosanoid and Docosanoid Precursor Fatty Acids Are Positively Associated: A Distribution Dependent Regulation

*Corresponding author: Arne Torbjørn Høstmark, Faculty of Medicine, Institute of Health and Society, University of Oslo, Norway. Received date: January 13, 2020; Accepted date: January 27, 2020; Published date: February 03, 2020 Citation: Høstmark AT. , Haug A. , (2020) Relative Amounts of Eicosanoid and Docosanoid Precursor Fatty Acids Are Positively Associated: A Distribution Dependent Regulation. J Nutrition and Food Processing, 3(1); DOI:10.31579/2637-8914/022
EFFECT OF RUMEN-PROTECTED LYSINE (HYDROXY METHYL LYSINE) SUPPLEMENTATION ON PERFORMANCE AND BLOOD METABOLITES IN BARKI SHEEP

Effect of rumen-protected lysine in the form of Hydroxyl methyl lysine (HML) on average daily gain (ADG), dry matter intake (DMI), nutrient digestibility, nitrogen balance blood metabolites, were evaluated in two experiments using growing Barki lambs. In first experiment, fifteen lambs were housed individually and assigned into three equal groups fed on basal diet (no lysine-control), free lysine (positive control, F-LYS) and protected lysine (P-LYS) equivalent to 3 g/d of lysine. The experiment lasted for 10 week to evaluate feed intake, ADG and blood metabolites. No effect (P>0.05) of treatment on ADG, DMI and feed efficiency was observed. Whereas, treatment × time interaction tendency (P=0.07) as showed an increased in ADG as lysine supplemented as P-LYS compared to F-LYS (P=0.05) and control (P 0.05) of treatment was observed on serum total protein (TP), albumin (Alb), globulin (Glob), urea, glucose (G), cholesterol (CH) and triglycerides (TG) concentrations. However, treatment × time interaction (P=0.06) tendency existed as P-LYS increased (P 0.05) was found on rumen ammonia nitrogen (NH3-N), pH and protozoa numbers. In Exp.2, (digestibility trial), twelve lambs from Exp.1 were kept in metabolic cages and received their respective treatments for 7 days as collection period. No response (P>0.05) to P-LYS supplementation was observed on nutrient digestibility of dry matter (DM), organic matter (OM), crude protein (CP), neutral detergent fibre (NDF) and acid detergent fibre (ADF) compared to F-LYS and control. A tendency (P=0.09) for treatment on nitrogen balance (NB) and retained nitrogen (RN, P=0.06) was found. P-LYS increased (P=0.05) NB to 7.1±0.14 vs. 4.8±0.3g/d and RN (P<0.05) from 37.9 vs. 25.59% in the control. However, P-LYS did not improve lambs performance under the basal diet fed that might have not been deficient enough in LYS amino acid, the improved ADG and decreased plasma urea at the last two weeks along with the slight improvement in NB and RN indicates the P-LYS has a potential under specific feeding regimes.
The Effect of Store Atmosphere, Product Quality, Customer Satisfaction and Electronic Word of Mouth on Customer Loyalty in Gubuk Coffee Padang

The study aim to Analyze The effect of Store atmosphere on Customer satisfaction, Product quality on Customer satisfaction, Customer satisfaction on Electronic word of mouth, Store atmosphere on customer loyalty, Product quality on customer loyalty, Customer satisfaction on customer loyalty, Electronic word of mouth on customer loyalty. The population in this study were Gubuk Coffee customers in Padang city with a sample of 205 respondents. Sampling techniques is Purposive sampling. Data analysis is SEM (Structural Equation Model) with PLS 3 program. The results of this study show that Store atmosphere has a significant effect on customer satisfaction, Product quality has a significant effect on customer satisfaction, Customer satisfaction has a significant effect on electronic word of mouth, Store atmosphere has a significant effect on customer loyalty, Products quality has a significant effect on customer loyalty, Customer satisfaction has a significant effect on customer loyalty.
Effect Of Different Planting Geometry And Application Of Liquid Organic Fertilizer On The Growth And Yield Of Abelmoschus Esculentus L. Intercropped With Vigna Unguiculata L.

The Increasing world population demands higher agricultural crop production to fulfill the food requirement. Therefore, intercropping is the best way to increase productivity in limited land area with organic inputs. To enhance the positive attitudes towards intercropping and organic farming, this experiment was carried out at the Crop Farm of Eastern University, Sri Lanka from January to April 2019 to study the effect of planting geometry with the application of liquid organic fertilizer (Jeewamirta) on the growth and yield of okra (Abelmoschus esculentus L) intercropped with Cowpea (Vigna unguiculata L.). The experiment was laid out in a Randomized Complete Block Design (RCBD) with four replications. Treatments were okra as a sole crop with the spacing of 90cm×60cm (T1), cowpea as a sole crop with the spacing of 30cm×15cm (T2), okra in 60cm×60cm with one row of cowpea (T3), okra in 90cm×60cm with 2 rows of cowpea (T4) and okra in 120cm×60cm with three rows of cowpea. This investigation revealed that there was a significant (p<0.05) effects in planting geometry in intercropping. The significant (p<0.05) highest values were obtained in okra with two rows of cowpea (T4) in plant height, leaf number, shoot biomass, root biomass, leaf area, average weight of fruit, 100 seed weight and yield than respective monocroppings. Further, Land Equivalent Ratio showed a significant (p<0.05) increase in T4. Therefore, it could be concluded that okra in 90 cm × 60cm with two rows of cowpea can be recommended for okra-cowpea intercropping to enhance the growth and yield.
Mass Transfer and Colour Analysis during Vacuum Frying of Colombian Coastal Carimañola

This study is aimed at analysing the effect of vacuum frying on the kinetic parameters of mass transfer, the CIE L∗a∗b∗ colour parameters of the Carimañola. For the kinetic analysis, the moisture and oil content were measured by means of an experimental design consisting of two factors: frying time with seven levels (60, 120, 180, 240, 300, 420, and 540 s) and frying temperature with three levels (120, 130, and 140°C). The diffusivity coefficient, the moisture transfer rate, and the oil adsorption rate, with their respective activation energies, were calculated. For the colour analysis, the reflectance technique was used to determine the colour coordinates of the CIE L∗a∗b∗ space, and the general colour change was calculated (ΔE). Concerning the kinetics, the increase in temperature and frying time reduced the moisture content, while the oil content decreased with the increase in temperature and increases with frying time. The diffusivity ranged from 1, 238 × 10−6 m2/s at 120°C to 2, 84 × 10−6 m2/s at 140°C. The mass transfer coefficients for moisture ranged from 2 × 10−4 m/s at 120°C to 4 × 10−4 m/s at 140°C. The values of the oil uptake rate were from 0.0022 s−1 at 120°C to 0.0018 s−1 at 140°C. Finally, the luminosity parameter shows a decrease with the increase in temperature, although the first 240 s shows a rise and then begins to decrease. Vacuum frying allowed Carimañolas to be obtained with a lower oil and moisture content, with an appropriate colouring, eye-catching and visually attractive to consumers.
The influence of DACCIWA radiosonde data on the quality of ECMWF analyses and forecasts over southern West Africa

During the DACCIWA (Dynamics–Aerosol–Chemistry–Cloud Interactions in West Africa) field campaign ∼900 radiosondes were launched from 12 stations in southern West Africa from 15 June to 31 July 2016. Subsequently, data‐denial experiments were conducted using the Integrated Forecasting System of the European Centre for Medium‐range Weather Forecasts (ECMWF) to assess the radiosondes' impact on the quality of analyses and forecasts. As observational reference, satellite‐based estimates of rainfall and outgoing long‐wave radiation (OLR) as well as the radiosonde measurements themselves are used. With regard to the analyses, the additional observations show positive impacts on winds throughout the troposphere and lower stratosphere, while large lower‐tropospheric cold and dry biases are hardly reduced. Nonetheless, downstream, that is farther inland from the radiosonde stations, we find a significant increase (decrease) in low‐level night‐time temperatures (monsoon winds) when incorporating the DACCIWA observations, suggesting a possible linkage via weaker cold air advection from the Gulf of Guinea. The associated lower relative humidity leads to reduced cloud cover in the DACCIWA analysis. Closer to the coast and over Benin and Togo, DACCIWA observations increase low‐level specific humidity and precipitable water, possibly due to changes in advection and vertical mixing. During daytime, differences between the two analyses are generally smaller at low levels. With regard to the forecasts, the impact of the additional observations is lost after a day or less. Moderate improvements occur in low‐level wind and temperature but also in rainfall over the downstream Sahel, while impacts on OLR are ambiguous. The changes in precipitation appear to also affect high‐level cloud cover and the tropical easterly jet. The overall rather small observation impact suggests that model and data assimilation deficits are the main limiting factors for better forecasts in West Africa. The new observations and physical understanding from DACCIWA can hopefully contribute to reducing these issues.
A Case Study on Overﬁtting in Multiclass Classiﬁers Using Convolutional Neural Networks

Convolutional Neural Networks (CNNs) have achieved much success mainly in areas of computational vision, such as image recognition, classiﬁcation, object segmentation, and more. The learning process of this type of network generally requires large volumes of data, commonly high-resolution images, and the adjustment of a large number of parameters. The lack of control over the learning process of the model can lead to various problems. One of them is overﬁtting, which leads the network to a situation where it loses generality, making incorrect forecasts in the presence of new data. Another very common problem is its speed of convergence, which depends on the parameterization of the network: selection of the number of ﬁlters per layer, number of convolution layers, and more, where a ﬁne adjustment is very important to avoid excessive computational costs. Understanding the origins of these problems and the ways to prevent them from happening is essential for a successful design. In this paper, we analyze these problems by designing a multiclass classiﬁer among ten categories of images from the Caltech 256 dataset, based on the metrics of accuracy, precision, recall, and loss. To do so, Python 3.6, TensorFlow and Keras libraries were used on an RTX 2060 GPU.
EFFECT OF OSCILLATING CRUDE PROTEIN CONTENT ON NITROGEN UTILIZATION, MILK PRODUCTION AND PERFORMANCE OF SHEEP

The objective of this study was to determine the effects of oscillating dietary crude protein on milk yield, composition, and N metabolism in ewes, and lambs performance. Twenty Barki ewes rearing single lamb (36.7 ± 1.78 kg and 6.38 ± 0.12 kg initial body weights of the ewes and their lambs, respectively) were used in a completely randomized design during a 10-week period of lactation. Ewes were fed a diet containing different levels of crude protein, 11.2% (low), 14.1% (Medium), 17.3% (High), or oscillating (Low and High crude protein diets oscillated for 3 days and 4 days, respectively). Dry matter intake did not differ among diets, but CP intake (g/d) differed (P<0.05) from 179 (low) to 230 (medium), 272 (high), and 229 (oscillating) g/ d. However, dry matter digestibility was not varied among diets, while that of crude protein was significantly differed (P<0.05) in which the highest value was for the high diet (69.6%) and the lowest one for the low crude protein diet (56.5%). An intermediate value was recorded for ewes fed the medium and oscillating crude protein diets (64.7%). Nitrogen retention was higher (P<0.05) in ewes fed high (14.6 g/d) and oscillating (12.8 g/d) diets than that in the ewes fed medium (10.0 g/ d) and low (8.0 g/d). Urinary urea N not differed (P<0.05) between ewes fed medium (12.1 g/d) and oscillating (11.6 g/d) but was lowest for those fed low (8.2 g/d) and greatest for those fed high (16.1 g/d). The pH and total VFA values did not differ among diets, but ammonia-N differed (P < 0.05) from 5.11 (low) to 10.63 (medium), 14.95 (high), and 12.37 mg/dl (oscillating). Microbial protein synthesis was higher (P < 0.05) in ewes fed oscillating (1.69) and high (1.64) than that reported in the ewes fed medium (1.49) or low (1.27 g/ 100 ml rumen liquid). Milk yield and composition did not differ among diets. Initial and final body weights of lambs are similar, but average daily gain (g/ d) significantly (P<0.05) differed (186, 194, 203 and 208 g/d for low, medium, high and oscillating, respectively). In conclusion, these data indicated that ewes fed oscillating diet varying in crude protein concentrations had an improvement in the crude protein digestibility, microbial protein synthesis and N retention compared with those fed low and medium dietary protein diets.
EFFECT OF USING BIOAKTIV OXYGEN ACTIVATED SODIUM CHLORIDE AS A NOVAEL ALTERNATIVE TO ANTIBIOTIC IN DRINKING WATER ON PERFORMANCE AND ENZYMES ACTIVITY OF BROILER CHICKS.

The study was designed to examine effects of using graded levels of oxygen activated sodium chloride (BioAktiv)in comparison to antibiotic on performance, serum metabolites and digestive enzymes activity in broiler chicks. One hundred eighty, one day old Ross broiler chicks were randomly allocated to four groups. The first group was control without water supplementation. While, the 2nd and 3rd groups received 0.5 and 1gm / 1L drinking water BioAktiv, respectively. The 4th one was given 500 ppm streptomycin (commercial streptomycin 5%) antibiotic. Chicks received the 4 experimental treatments up to the age of 35 day of age. Chicks given different levels of BioAktiv, recorded higher live body weight (LBW) and body weight gain (BWG) ,better feed conversion ratio (FCR) comparable to both antibiotic and control groups. The highest (p<0.01) digestive enzyme activities (amylase, protease) were reported for chicks given NaCl gm/1L BioAktiv, followed by those of antibiotic and the control groups. Highly significant increase (p<0.01) in the serum concentration of total proteins and globulin was observed in groups received the different levels of BioAktiv compared to those of the untreated and antibiotic ones , Likewise, the levels of serum T3 and T3/T4 ratio;recorded higher level with treated groups, however, T4 value was insignificantly differed among all groups. Beyond, watery BioAktiv addition had hypolipemic and hypocholesterolemic effects, but had no effect on liver and kidney functions. These findings imply that, BioAktivmight be considered as a safe water-added antibiotic alternative having affirmative effect on growth performance, gastrointestinal tract (GIT) health and the physiological homeostasis of broiler chicks.
Creative Destruction? Local Business Conditions, Firm Age, and Wages.

While a growing literature has examined the relationship between economic shocks and job creation in startups and established firms, little is known about the quality of these jobs. In this paper, I examine how fluctuations in local business conditions affect the wages of employees at startups and incumbent firms. I identify shocks to local business conditions using plausibly exogenous variation of hurricane strikes in U.S. coastal counties. I find that wages of startup employees increase substantially in response to negative shocks to local business conditions, while there is only a small raise in old firms. This effect does not appear to be driven by changes in supply or demand for labor. These findings are consistent with “cleansing” theories of downturns.
A new age model for the Pliocene of the southern North Sea basin: a multi-proxy climate reconstruction

Abstract. The mid-Piacenzian Warm Period (mPWP; 3264–3025 ka) represents the most recent interval in Earth's history where atmospheric CO2 levels were similar to today. The reconstruction of sea surface temperatures (SSTs) and climate modelling studies has shown that global temperatures were 2–4 ∘ C warmer than present. However, detailed reconstructions of marginal seas and/or coastal zones, linking the coastal and continental climate evolution, are lacking. This is in part due to the absence of precise age models for coastal sedimentary successions, as they are generally formed by dynamic depositional systems with varying sediment and freshwater inputs. Here, we present a multi-proxy record of Pliocene climate change in the coastal southern North Sea basin (SNSB) based on the sedimentary record from borehole Hank, the Netherlands. The marginal marine setting of the Hank borehole during the late Pliocene provides an excellent opportunity to correlate marine and terrestrial signals due to continental sediment input mainly derived from the proto-Rhine–Meuse River. We improve the existing low-resolution palynology-based age model for the Hank borehole using stable oxygen and carbon isotope ( δ18O and δ13C ) measurements of the endobenthic foraminifera species Cassidulina laevigata, integrated with biochrono- and seismostratigraphy. Identification of hiatuses and freshwater effects in the record allows us to isolate glacial–interglacial climate signals in order to tune the endobenthic oxygen stable isotope record to a global benthic δ18O stack. This results in a tuned age framework for the SNSB for the late Pliocene ( ∼3190 –2770 ka). Our multi-proxy climate reconstruction for the interval which covers part of the mPWP ( ∼3190 –3000 ka) shows a strong agreement between lipid biomarker and palynology-based terrestrial temperature proxies, which suggest a stable climate, 1–2 ∘ C warmer than present. In the marine realm, however, biomarker-based SSTs show a large range of variation (10 ∘ C). Nevertheless, the fluctuation is comparable to other SST records from the North Atlantic and Nordic Seas, suggesting that a common factor, possibly ocean circulation, exerted a strong influence over SSTs in the North Atlantic and the North Sea at this time.
Offensive or Not? Examining the Impact of Racial Microaggressions

Although the literature suggests that there exist harmful consequences of microaggression, some researchers argue that the state of the current literature lacks evidence that these indignities are in fact offensive to individuals holding marginalized identities. To address this gap, researchers sought to examine the perspectives of university students, as individuals at a Predominantly White Institution (PWI) provided ratings to indicate their experiences with and interpretation of verbal racial insults that had been previously identified as microaggressive by previous researchers. Results of the study demonstrates that there are differences in how university students interpret microaggressions. Specifically, the obtained data suggest that race, gender, sexual orientation, and prior exposure to the microaggressions are significant predictors to one’s interpretation of them as offensive or insulting. Implications regarding the state of the literature and the experiences of individuals at PWIs and future directions surrounding the research methodologies that are employed to study microaggressions are discussed.
Identifying the Profile of a Potential Lifelong Learner.

Based on the 21st century’s framework from the Singapore’s Ministry of Education, students should possess lifelong learning goals in order to be self-regulated and engaged in continuous learning. It is thereby important to understand the profile of a potential lifelong learner. An educational institution or a school should provide learning environments in which students can be more involved in developing their competencies and skills that are related to lifelong learning. However, research in identifying the profile of a potential lifelong learner is still in its infancy. The present study aimed to uncover an in-depth and meaningful understanding of different learners’ behaviours, ranging from adaptive to maladaptive patterns of goal orientations. It drew on four different clusters to identify the self-regulation and self-determined behaviours of a lifelong learner. These learner profiles differed significantly in their basic psychological needs (i.e., autonomy, competence and relatedness) and goal orientations (i.e., mastery versus performance).