Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacologic Considerations in the Disposition of Antibodies and Antibody-Drug Conjugates in Preclinical Models and in Patients

The rapid advancement in the development of therapeutic proteins, including monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs), has created a novel mechanism to selectively deliver highly potent cytotoxic agents in the treatment of cancer. These agents provide numerous benefits compared to traditional small molecule drugs, though their clinical use still requires optimization. The pharmacology of mAbs/ADCs is complex and because ADCs are comprised of multiple components, individual agent characteristics and patient variables can affect their disposition. To further improve the clinical use and rational development of these agents, it is imperative to comprehend the complex mechanisms employed by antibody-based agents in traversing numerous biological barriers and how agent/patient factors affect tumor delivery, toxicities, efficacy, and ultimately, biodistribution. This review provides an updated summary of factors known to affect the disposition of mAbs/ADCs in development and in clinical use, as well as how these factors should be considered in the selection and design of preclinical studies of ADC agents in development.
Characterization of abundance and diversity of lactic acid bacteria from Apis dorsata hives and flowers in East Nusa Tenggara, Indonesia

Karyawati AT, Nuraida L, Lestari Y, Meryandini A. 2018. Characterization of abundance and diversity of lactic acid bacteria from Apis dorsata hives and flowers in East Nusa Tenggara, Indonesia. Biodiversitas 19: 899-905. Previous research on lactic acid bacteria associated with honey bees has been conducted in temperate arid regions and wet tropical regions. We isolated lactic acid bacteria from giant honey bee (Apis dorsata) hives and flowers in East Nusa Tenggara, Indonesia, an area with a tropical savanna climate. Diversity of lactic acid bacteria was studied using Denaturing Gradient Gel Electrophoresis method. The purpose of this study was to obtain information about the diversity of lactic acid bacteria contained in Apis dorsata hives and flowers from tropical savanna climate. We identified seven Operational Taxonomy Units (OTU) within the hives and flowers. Two OTUs were closely related to LactoBacillus kunkeei strain YH-15 (T), while three others were closely related to Lactococcus lactis subsp. tructae strain L105 (T). This information is important to explore the potential utilization of lactic acid bacteria in maintaining human health.
Audiencias activas y desigualdad de ingresos: análisis exploratorio de la conversación en Twitter 

La desigualdad de ingresos es uno de los mayores desafíos de nuestras sociedades y uno de los temas principales de la agenda política reciente (Pickett y Wilkinson, 2015: 132), especialmente desde el colapso financiero global. Como Mike Savage (2016) afirma, “la desigualdad está en todas partes, en las representaciones que los medios hacen de la realidad, así como en nuestra vida social diaria o en las redes sociales”. Las redes sociales tienen el potencial de facilitar una democracia más participativa y un valor disruptivo para desafiar los intereses tradicionales y los modos de poder comunicativo (Loader y Mercea, 2011). Por lo tanto, nuestro objetivo es describir cómo se crea la opinión pública en relación con el concepto de desigualdad de ingresos en Twitter. Desde un punto de vista metodológico, tras haber realizado un análisis cuantitativo en trabajos previos, proponemos explorar el cualitativo a través de la recolección de 102.082 tuits en 2018 sobre el concepto de desigualdad de ingresos.
The impact of flexible working at firm level. Evidence from Greek labor market

Global competition and the rise of structural unemployment during the 1980s and 1990s increased the demand for flexibility at labor markets. Since the early1990s, Greece following the directives of the European Union, gradually adopted reforms to ease the use of flexible forms of employment. This paper maps the recent evolution of flexible employment in Greece and makes an innovative empirical analysis of the employers' opinion about the impact of flexible working on their businesses during the crisis. The analysis is based upon a questionnaire through which the problem is investigated with the help of the statistical software R. To compare the sub-samples and in order to test any potential differences between them, we applied the Χ2 (chi square) analysis. We used a sample of almost 1000 respondents, drawn from the Greek SME sector, during the period October – December 2018. The results of our research seem to confirm the related findings of earlier studies. Our descriptive analysis shows that the impact of flexible working forms on entrepreneurship in Greece is ambiguous. In particular, it is concluded that flexible working forms has not contributed to human resource management. On the contrary, it seems that flexible working can reduce labor and insurance costs.
Vitamine D, calcium et acides gras. Lien avec l'obésité chez la femme

Obesity is a growing health problem. Many approaches have been proposed in order to prevent or treat this metabolic disease affecting our society. Diet has been the focus of several studies and represents a key element in the prevention and management of the obesity epidemic. A multitude of diets have been created in order to reduce body weight. The general idea emerging from the studies comparing various diets is that weight loss will be proportional to adherence to the regimen. Some specific components of the diet have also been studied in association with obesity. Calcium and vitamin D intakes are two nutrients that are discussed in this essay. We demonstrated that a higher consumption of calcium and vitamin D is linked to a favorable lipid profile as well as smaller omental adipocytes. Furthermore, vitamin D was found to be the best predictor of omental adipocyte size independently of calcium intakes. Fatty acids have also been examined in relation to obesity. Our work gave us the opportunity to compare the fatty acid intake with its counterpart in adipose tissue. A striking similarity was observed. Our main finding was that women with higher adipose tissue stearic acid content had smaller omental adipocytes. Moreover, the mRNA and protein levels of Stearoyl-CoA désaturase, which converts stéarate into oleate, were positively correlated with body fat mass. This finding corroborated our results. In conclusion, we provide new information on specific factors that may influence the etiology of obesity. However, it may be too early to modify clinical practice. Further studies are necessary to learn how the two components that we have studied can help us in the fight against obesity.
Evaluating the Energy-Saving Effects of a Utility Demand-Side Management Program: A Difference-in-Difference Coarsened Exact Matching Approach

This paper seeks to estimate the energy-saving effect of a Demand-Side Management program, specifically Gainesville Regional Utility’s (GRU) high-efficiency central Air Conditioner (AC) rebate program in which GRU offers incentives to its customers to replace their old, low-efficiency AC unit with a high-efficiency model. We use a difference-in-difference coarsened exact matching approach to reduce the imbalance of pre-treatment characteristics between treated and control households. We find substantial annual energy savings of the high-efficiency AC program. We disaggregate the energy-saving effects into summer peak effects, winter peak effects, and non-peak effects. The results indicate that the summer peak effects are substantial and statistically significant while there are little or no statistically significant effects of the program on winter peak demand. Also, by following program participants over a three-year period, we find that there is no statistically significant rebound effect of the high-efficiency AC rebate program.
Trajectory Drift–Compensated Solution of a Stereo RGB-D Mapping System

Multiple sensors are commonly used for three-dimensional (3D)-mapping or robotic-vision applications, as they provide a larger field of view and sufficient observations to fulfill frame-registration and map-updating tasks. However, the data sequences generated by multiple sensors can be inconsistent and contain significant time drift. In this paper, we describe the trajectory drift–compensated strategy that we designed to eliminate the influence of time drift between sensors, remove the inconsistency between the sequences from various sensors, and thereby generate a coarse-to-fine procedure for robust camera-tracking based on two-dimensional–3D observations from stereo sensors. We present the mathematical analysis of the iterative optimizations for pose tracking in a stereo red, green, blue plus depth (RGB-D) camera. Finally, complex indoor scenario experiments demonstrate the efficiency of the proposed stereo RGB-D simultaneous localization and mapping solution. The results verify that the proposed stereo RGB-D mapping solution effectively improves the accuracies of both camera-tracking and 3D reconstruction.
DETERMINAN PARTISIPASI ANGKATAN KERJA PEREMPUAN DI SUMATERA BARAT

Women's participation in the workforce is strongly influenced by social, economic and cultural factors. As a result women LFPRs both overall and based on age groups are very different from time to time, and between countries / regions one with another country / region. Thus, this study aims to explore the determinants of female labor participation in West Sumatra, because the growth of female labor in West Sumatra is quite large, but female labor participation is still low and there is a considerable difference compared to male labor. This research is a quantitative study, which uses the raw data of the National Socio-Economic Survey (SUSENAS) of West Sumatra Province in 2017. The individual factors used in the information are education, age, area of ​​residence and marital status. The data analysis techniques used are Crosstabulation descriptif analysis and logistic regression analysis.The results showed that overall the probabilistic models of factors that influence female labor participation in West Sumatra Province were estimated by logistic regression models to give good results and empirical behavior towards the variables studied according to the expectations of theoretical behavior when viewed from the suitability of the signs. Adult age affects the level of female labor participation rather than having a young age. The high level of education, women prefer to work. Residence in the village has a higher influence on female labor participation than in the city. Married women tend to help the family economy in the labor market.
INFLUENCE OF SOIL TEXTURE, CLIMATE AND VEGETATION COVER ON SECONDARY SOIL SALINIZATION IN PAMPAS PLAINS, SOUTH AMERICA

on soil electrical conductivity (EC) was studied in grassland ABSTRACT Land-use change from herbaceous to woody cover -or vice versa- largely affects water fluxes, which in turn can mobilize existing salts dissolved in the soil, and thereby negatively affect soil and/or water quality and site productivity. Secondary salinization was observed after afforestation at the Northern and Eastern subregions of the Río de la Plata Grassland. Based on this, our objective was to determine the degree of association between the climatic (e.g. water balance), edaphic (e.g. texture, presence of petrocalcic horizons) and biological factors (age of plantation, stand density and stand basal area) with the secondary salinization processes under the particular environmental conditions of the Austral Pampas. The lowest electrical conductivity (EC, μS.cm -1 ) values were found in sites with sandy-textured soils and negative water balance, regardless of tree canopy cover. When EC differences did occur between land uses of the same site (50% of the sites), in most cases – but not in all of them – the highest EC was measured under tree cover. When salinization was significant, no pattern was observed in the salt distribution along the soil profile. An increase of EC was associated with the oldest-unmanaged plantations, with mean age of 40 years, a period much longer than the productive rotation recommended. Under similar edaphic conditions where salinization was observed (i.e. clayed soils, with naturally high salt level), salinization was not significant in relatively young plantations (<rotation period), demonstrating the key role of forest management to decrease its negative impacts on soils.
Evaluation of a Non-Nuclear Soil Density Gauge on Fine-Grained Soils

Abstract : This report presents results from an evaluation of a non-nuclear soil moisture-density gauge, the Soil Density Gauge (SDG 200), tested on a series of 16 different fine-grained soils. If the results were successful, the device would serve as a replacement to the standard nuclear moisture-density gauge. Results from a standard nuclear moisture-density gauge were used for comparison. Results of the tests are presented and include comparisons of the dry densities obtained from the SDG and the nuclear gauge. Correlations between the two devices showed a strong dependence on plasticity characteristics to distinguish among soil types. The lack of internal calibration for fine soils demonstrated poor correlation between moisture conditions for a given soil. Similar to SDG studies on coarser soils, the proper response from the SDG for fine-grained soils requires calibration of the dry density using at least one independent density sample obtained in the field with an alternative device such as a sand cone or a nuclear moisture-density gauge.
A COMPARATIVE STUDY OF PHYSICAL PROPERTIES USING VARIOUS GRADES ASPHALT BINDER WITH DIFFERENT TYPE OF FIBERS

For a long time, bitumen has been utilized as the essential material for asphalt pavement construction. The factors of increasing axle loads, increasing traffic movement, critical climate conditions and many forms failures in construction have steered many researchers to seek some methods to enhance the asphalt binder properties. Even though various types of modifiers have been utilized in strengthening asphalt concrete, fibers have attracted the most attention due to their high and desirable characteristics. It is realized that the good distribution of the modifier in asphalt binder can generate a strong network in the interior structure of the blend, causing bitumen mastic to be more coherent. In this study, a laboratory investigation of the rheological and physical properties of various grades of bitumen modified by two types of fibers was conducted. Three grades of asphalt were used in this study (60-70 penetration grade, 80-100 penetration grade and PG-76 grade) with two types of fibers with different percentages- Cellulose oil palm fiber (COPF) (0.15, 0.3, 0.45, 0.6, and 0.75%) by weight of asphalt and carbon fiber (0.75, 1.25, 1.75, 2.25, and 2.75%) by weight of asphalt. The results showed enhancement in physical performance of the modified bitumen in terms of the decrease in penetration values, as well as a rise in the softening point and viscosity values. The fibers’ modified asphalt binders showed improved rheological properties and can raise the grade of asphalt depending on the base asphalt type.
Sweat Characteristics in Individuals With Varying Susceptibilities of Exercise-Associated Muscle Cramps

Abstract Szymanski, M, Miller, KC, O'Connor, P, Hildebrandt, L, and Umberger, L. Sweat characteristics in individuals with varying susceptibilities of exercise-associated muscle cramps. J Strength Cond Res 36(5): 1171–1176, 2022—Many medical professionals believe dehydration and electrolyte losses cause exercise-associated muscle cramping (EAMC). Unlike prior field studies, we compared sweat characteristics in crampers and noncrampers but accounted for numerous factors that affect sweat characteristics including initial hydration status, diet and fluid intake, exercise conditions, and environmental conditions. Sixteen women and 14 men (mean ± SD; age = 21 ± 2 year, body mass = 69.1 ± 11.6 kg, height = 171.4 ± 9.9 cm) self-reported either no EAMC history (n = 8), low EAMC history (n = 10), or high EAMC history (n = 12). We measured V̇o2max, and subjects recorded their diet. At least 3 days later, subjects ran at 70% of their V̇o2max for 30 minutes in the heat (39.9 ± 0.6° C, 36 ± 2% relative humidity). Dorsal forearm sweat was collected and analyzed for sweat sodium concentration ([Na+]sw), sweat potassium concentration ([K+]sw), and sweat chloride concentration ([Cl−]sw). Sweat rate (SWR) was estimated from body mass and normalized using body surface area (BSA). Dietary fluid, Na+, and K+ ingestion was estimated from a 3-day diet log. We observed no differences for any variable among the original 3 groups (p = 0.05–p = 0.73). Thus, we combined the high and low cramp groups and reanalyzed the data against the noncramping group. Again, there were no differences for [Na+]sw (p = 0.68), [K+]sw (p = 0.86), [Cl−]sw, (p = 0.69), SWR/BSA (p = 0.11), dietary Na+ (p = 0.14), dietary K+ (p = 0.66), and fluid intake (p = 0.28). Fluid and electrolyte losses may play a more minor role in EAMC genesis than previously thought.
DDOS Attack Detection Using Machine Learning

: Over the last few decades, the Internet has absolutely changed the world. However, the tremendous growth of Internet brought many cyber-attacks. Distributed denial service attack is considered one of the most dangerous attacks. Distributed denial of service is a critical threat that is responsible for halting the normal functionality of services in cloud computing environments. Distributing Denial of Service attacks is categorized in the level of crucial attacks that undermine the network's functionality. These attacks have become sophisticated and continue to grow rapidly, and it has become a challenging task to detect and address these attacks contains.
Expanding the footprint of sexual harassment prevention training: A power, credit, and leadership perspective

Current approaches to sexual harassment and discrimination training remain limited in their effectiveness due to a series of issues highlighted by Hayes et al. (2020), including poorly designed training programs, a failure to understand the issue, and the misapplication of psychological principles. Additionally, other issues with sexual harassment training have been highlighted in previous volumes of this journal, including inappropriate measurement and a limited lens on shortterm outcomes (Medeiros & Griffith, 2019a) as well as the potential for backlash (Steele & Vandello, 2019). The stakes involved with both sexual harassment and discrimination warrant attention to these issues and a concentrated effort on improving these programs in order to make a real impact. As such, we agree with the perspective presented by Hayes and colleagues, and wish to extend their conversation on the application of psychological principles in sexual harassment interventions by discussing the role of idiosyncrasy credits and the impact of power dynamics in the perpetuation of harassment in the workplace. As per Williams et al. (1999), holding those who engage in sexual harassment accountable is a critical factor in the reduction of workplace sexual harassment. Hayes et al. (2020) note this finding as well, and we believe it warrants additional consideration in the conversation given recent workplace sexual harassment statistics in which HR professionals and employees disagreed significantly regarding the extent to which incidents go unreported (SHRM, 2018). HR professionals endorsed the opinion that unreported incidents are not a major problem nearly twice as often as employees, suggesting that policy makers and enactors are out of step with the experiences of their employees. Available evidence suggests that sexual misconduct goes unreported for reasons ranging from fear of retaliation to a belief that nothing will change (e.g., McLaughlin et al., 2017). Even experimental studies have explored practical workplace implications associated with sexual harassment. For instance, Hart (2019) found that those who evaluated candidates who reported their own sexual harassment were far less likely to recommend them for promotion compared to those who did not mention harassment or had a colleague report on their behalf. Sexual harassment also directly impacts the career choices of women, as those who are sexually harassed are 6.5 times more likely to leave an organization (McLaughlin et al., 2017). These results are mirrored in over 20 years of research on the relationship between sexual harassment and turnover. It would seem, then, that failing to develop and impose consequences on those who engage in sexual harassment results in consequences for those who experience workplace harassment. In light of this, here, we consider two possible barriers to accountability.
In situ synthesis of star copolymers consisting of a polyhedral oligomeric silsesquioxane core and poly(2,5‐benzimidazole) arms for high‐temperature proton exchange membrane fuel cells

Star copolymers with good film‐forming and mechanical properties were in situ synthesized for fabricating proton exchange membranes. The monomers of 3,4‐diaminobenzoic acid were first grafted onto glycidyl‐polyhedral oligomeric silsesquioxane (G‐POSS) cores and then propagated to the poly(2,5‐benzimidazole) (ABPBI) chains. The introduction of the star copolymer improves the movement of the ABPBI polymer chains, resulting in a lower internal viscosity and larger free volume that favor increased membrane flatness and absorbilities of water and phosphoric acid molecules, respectively. It was found that the star copolymers with 1.0 wt% of incorporated POSS (ABPBI‐1.0POSS) had the best balance of the acid retentivity and film‐forming property as well as mechanical properties that are desirable for proton exchange membranes without PA loss operating at high temperatures. The enhanced cell performance characteristics obtained using the ABPBI‐1.0POSS‐based membranes indicate that star copolymers are promising materials for use in high‐temperature proton exchange membrane fuel cells.
Can Prompting Investors to be in a Deliberative Mindset Reduce Their Reliance on Fake News?

We examine if prompting investors to be in a deliberative mindset reduces their reliance on financial news that is later revealed to be fake. Consistent with theory, results of an experiment show that investors reduce their reliance on news revealed to be fake, and that this reduction is magnified for investors who were previously prompted to be in a deliberative mindset. Importantly, results also reveal that prompting investors to be in a deliberative mindset does not affect their judgments when the news is later revealed to be true. Our study contributes to research on fake news in the financial markets and has practical implications for investors when evaluating news that may be true or fake.
Broadband Penetration and Economic Growth: Evidence from Nigeria

This paper investigated the relationship between broadband penetration and economic growth in Nigeria. The secondary data for the study were collected from the World Bank and this includes data on Internet broadband usage and Gross Domestic Product while the primary data were generated from the questionnaire administered to the respondents. The descriptive statistics and the ordinary least square regression analytical method were used to examine the relationship between broadband penetration and economic growth. It was discovered that a per cent increase in broadband penetration will only increase output (Economic Growth) by 0.1 per cent in Nigeria. The data analysis showed a significant and positive relationship between broadband penetration and economic growth. The study thus recommended that efforts must be made towards the implementation of broadband policy and effective utilization of the broadband network. Also, better telecommunication reforms that will create enabling environment and encourage the inflow of broadband networks should be made.