Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of Neurological Adverse Events Reported in VigiBase From COVID-19 Vaccines

Background: Fifteen COVID-19 vaccines have been granted emergency approval before the completion of conventional phases of clinical trials. The present study aimed to analyze the neurological adverse events (AEs) post-COVID-19 vaccination and focuses on determining the association of AEs with the vaccine. Methodology: The neurological AEs reported for COVID-19 vaccines in the WHO pharmacovigilance database (VigiBase) were extracted from the System Organ Classes - neurological disorders and investigations. Descriptive statistics are reported as percentage and frequency and the disproportionality analysis was also conducted. Results: For the neurological system, 19,529 AEs were reported. Of these, 15,638 events were reported from BNT162b2 vaccine, 2,751 from AZD1222 vaccine, 1,075 from mRNA-1273 vaccine, eight from Vero vaccine, two from Covaxin, and for 55 AEs, vaccine name was not mentioned. The reason for more AEs reported with BNT162b2 can be maximum vaccination with BNT162b2 vaccine in the study period. According to the disproportionality analysis based on IC025 value, ageusia, anosmia, burning sensation, dizziness, facial paralysis, headache, hypoaesthesia, lethargy, migraine, neuralgia, paresis, parosmia, poor sleep quality, seizure, transient ischemic attack, and tremor are some of the AEs that can be associated with the administration of the vaccine. Conclusion: The vaccines should be monitored for these AEs till the causality of these AEs with COVID-19 vaccines is established through further long-term follow-up studies. These neurological AEs reported in VigiBase should not be taken as conclusive and mass vaccination should be carried out to control the pandemic until a definite link of these adverse effects is established.
Analysis on Deformation Failure and Structural Mechanical Characteristics of Multistage Loess Slope Supported by Frame Structure with Anchors

Frame anchor supporting structure is widely accepted in the loess area, especially in the multistage slopes along the road. However, the development between theory and practice is not synchronous, and there exist experience and uncertainty in the design process to a great extent. In response to this problem, the multistage loess slope supported by frame structure with anchors is taken as the research object, and the model test is carried out with the help of the large-scale geotechnical centrifuge under the condition of using prototype materials as much as possible. Then, according to the test data and phenomena, the structural stress and slope deformation concerned in the project are analyzed. The main differences in stress and deformation between the multistage loess slope supported by frame structure with anchors and other types of slopes are pointed out, and some targeted suggestions are given. The research results show that the frame anchor supporting structure and soil can always maintain coordinated deformation during centrifugal loading, and the failure process has certain toughness characteristics. The stress characteristics of the anchor rod and the sliding deformation range of the slope in the multistage loess slope supported by frame structure with anchors are different from the slope with structural surface and single-stage slope. The length of the anchoring section cannot be completely determined based on the potential sliding surface in the design. It is reasonable to strictly control the end position of the anchoring section from the perspective of changing the position of the potential sliding surface. The results obtained can enrich and improve the stability theory of multistage loess slope and provide guidance for engineering practice.
Clinical characteristics, complications, and predictors of outcome of hospitalized adult Sudanese patients with COVID‐19 and malaria coinfection in Sudan: A multicenter retrospective cross‐sectional study

Malaria and coronavirus disease 2019 (COVID‐19) share several characteristics that could lead to cross‐infection, particularly in malaria‐endemic areas. Early COVID‐19 symptoms might be misdiagnosed for malaria in clinical settings. Also, both diseases can cause fatal complications. So, laboratory testing for both diseases was recommended by the World Health Organization. To study the clinical characteristics and outcomes of Adult Sudanese patients with COVID‐19 and malaria coinfection. This retrospective cross‐sectional study was conducted from January 2021 to October 2021 in Wad Medani. Total coverage of all Sudanese patients above 18 years old with a confirmed diagnosis of coinfection with COVID‐19 and malaria was included, and data were collected using a data collection sheet. Data were analyzed using R software version 4.0. 2. Data were described and presented as mean, standard deviation, and number (percentage). To find associated factors with in‐hospital outcome, χ2 test, fisher exact test, and independent t test or Wilcoxon rank‐sum test were used. In this study, 156 participants were diagnosed with COVID‐19 and malaria coinfection. Most of them were between 60 and 70 years (30.8%), the majority were males (59%). Shortness of breath (76.3%) and acute respiratory distress syndrome (35.3%) were the most common symptom and complications among coinfected patients, respectively. Ground glass opacity (n = 47/49, 95.9%) is the most common result for computed tomography scan. Atrial fibrillation was the most common abnormal electrocardiogram finding (n = 6/62, 9.7%). Overall mortality among all participants was (63/156, 40.4%). High mortality rate was found among the coinfected patients. More attention is needed towards fighting COVID‐19 and malaria coinfection. There may be a link between malaria and COVID‐19.
Demography, growth and robots in advanced and emerging economies

This paper provides estimates of the impact of demographic change on labor productivity growth, relying on annual data over 1961-2018 for a panel of 90 advanced and emerging economies. We find that increases in both the young and old population shares have significantly negative effects on labor productivity growth, working via various channels— including physical and human capital accumulation. Splitting the analysis for advanced and emerging economies shows that population ageing has a greater effect on emerging economies than on advanced economies. Extending the benchmark model to include a proxy for the robotization of production, we find evidence indicating that automation reduces the negative effects of unfavorable demographic change—in particular, population aging—on labor productivity growth.
The Synergistic Effect of Biosynthesized Silver Nanoparticles and Phage ZCSE2 as a Novel Approach to Combat Multidrug-Resistant Salmonella enterica

The emergence and evolution of antibiotic-resistant bacteria is considered a public health concern. Salmonella is one of the most common pathogens that cause high mortality and morbidity rates in humans, animals, and poultry annually. In this work, we developed a combination of silver nanoparticles (AgNPs) with bacteriophage (phage) as an antimicrobial agent to control microbial growth. The synthesized AgNPs with propolis were characterized by testing their color change from transparent to deep brown by transmission electron microscopy (TEM) and Fourier-Transform Infrared Spectroscopy (FTIR). The phage ZCSE2 was found to be stable when combined with AgNPs. Both minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated for AgNPs, phage, and their combination. The results indicated that MIC and MBC values were equal to 23 µg/mL against Salmonella bacteria at a concentration of 107 CFU/mL. The combination of 0.4× MIC from AgNPs and phage with Multiplicity of Infection (MOI) 0.1 showed an inhibitory effect. This combination of AgNPs and phage offers a prospect of nanoparticles with significantly enhanced antibacterial properties and therapeutic performance.
Amplification of Lamb-wave detection via fiber Bragg gratings using ultrasonic horns

Fiber Bragg Grating (FBG) sensors are often applied as Lamb wave detectors for structural health monitoring systems. Analyzing the measured signal for the identification of structural damage requires a high signal-to-noise ratio because of the low amplitude Lamb waves. This paper applies a two-dimensional ultrasonic horn between the structure and a remotely bonded FBG sensor to increase the amplitudes of the measured signal. Experimentally we test a variety of ultrasonic geometries and demonstrate a 100% increase in the measured ultrasonic signal amplitude using a metallic ultrasonic horn with step-down geometry. A bonding procedure for the combined ultrasonic horn and optical fiber is also developed that produces repeatable signal measurements. For some horn geometries, an additional vibration signal at the Lamb wave excitation frequency is observed in the measurements. Laser Doppler vibrometry measurements and finite element analysis demonstrate that the signal is due to the natural vibration of the horn. The experimental results demonstrate that using an aluminum ultrasonic horn to focus wave is an excellent method to increase the sensitivity of the FBG to the small amplitude Lamb wave, provided the horn vibration characteristics are taken account in the design of the measurement system.
Methodology for Complete Decorrelation of Power Supply EM Side-Channel Signal and Sensitive Data

Electro-magnetic (EM) side channel attacks have become a serious threat to security of Internet-of-Things (IoT) devices. Power supply generated by voltage regulators is one of the most common attack targets due to its strong EM emanations. In this brief we derive analytical conditions for complete theoretical decorrelation of the power supply EM side-channel signal and the sensitive data. The output of the power supply converter is modelled as amplitude modulation (AM) of the load signal by the converter capacitance that acts as a carrier. By applying Price theorem (Papoulis and Pillai, 2002), we obtain the exact theoretical conditions that converter capacitance needs to fulfil in order to prevent EM side-channel attacks. The conditions are further adapted for practical implementation. When the proposed methodology is applied to AES measured traces, the correlation coefficient between the leaked signal and the sensitive data is 0.05. Such low correlation indicates the proposed methodology is a promising candidate against the attacks that exploit AM signals to extract sensitive data, such as, TEMPEST and active EM attacks. Test Vector Leakage Assessment (TVLA) $\rho $ -test detects no leaky points, thereby confirming circuit protection against differential and correlation EM attacks as well.
From Homeowner to Airbnb Host: The Role of Trust and Perceived Value

ABSTRACT To investigate the effects of trust and perceived value on the intentions to engage in hosting Airbnb, this study builds a multivariate model to explore the difference exists between Airbnb hosts and potential hosts. The empirical results reveal that perceived value is a major motivation for homeowners, while trust becomes the primary driving force for hosts continuing to use Airbnb. Perceived usefulness, ease of use, risks of Airbnb, and familiarity and personal innovativeness of users are furtherly examined as secondary variables. This study provides practical implications for the accommodation sharing platforms to improve the e-service quality and formulate marketing strategies.
A Motion Similarity Measurement Method of Two Mobile Devices for Safety Hook Fastening State Recognition

Fall from height (FFH) is an accident that leads to fatalities in construction workers, and a major cause of FFH is due to the improper fastening of a safety hook of a safety harness to a temporary structure. In this study, we propose a new approach for recognizing the fastening state of the safety hook based on the similarity of motion between the motion of the hook and the body. We first assume that the similarity of motion between a hook and a body will be more similar when a hook is fastened to a part of a body than when the hook is fastened to a temporary structure. Under this assumption, we propose a new method that measures the similarity of motion of a hook and a body. In the proposing method, motions are represented through acceleration and rotations of the hook and the body. The magnitude of acceleration is represented as an ordinal variable and the magnitude of acceleration is jointly represented with rotations in a spherical coordinate system for effective similarity measurement of both motions. The effectiveness of our approach is verified by our newly collected task-related human activity dataset comprising the motion data of the hook and the body from inertial measurement unit (IMU) embedded mobile devices. Our proposed method confirmed that representing the magnitude of acceleration as an ordinal variable shows improved performance of 82.95% in terms of Youden’s index. Moreover, it further verified that jointly representing the magnitude of acceleration and the rotation in the spherical coordinate system shows improved performance of 90.64% in terms of Youden’s index.
Major shift or business as usual? An investigation on the impacts of responsible management education

Abstract Various curricula and educational materials for responsible management education (RME) have been developed by business schools from different parts of the world for sustainable development. There is, however, limited research on the effectiveness of these courses. By conducting surveys before and after the semester among business students from two RME courses, this study investigated the impacts on students’ awareness of and attitudes toward ethical and sustainable issues in business practices. Findings show that students have enriched their understanding of the issues, have a positive attitude toward RME, but need a stronger driver of behavioral change.
Social Connectedness in Physical Isolation: Online Teaching Practices That Support Under-Represented Undergraduate Students’ Feelings of Belonging and Engagement in STEM

The COVID-19 outbreak spurred unplanned closures and transitions to online classes. Physical environments that once fostered social interaction and community were rendered inactive. We conducted interviews and administered surveys to examine undergraduate STEM students’ feelings of belonging and engagement while in physical isolation, and identified online teaching modes associated with these feelings. Surveys from a racially diverse group of 43 undergraduate students at a Hispanic Serving Institution (HSI) revealed that interactive synchronous instruction was positively associated with feelings of interest and belonging, particularly for students of color, while noninteractive instruction reduced social belonging, but was related to more cognitive engagement. Small group and one-on-one interviews with 23 of these students suggest that students derived feelings of connectedness from their instructors, peers, and prior experiences and relied on their sense of competency to motivate themselves in the course and feel a sense of belonging. Two embedded cases of students in physics classrooms are compared to highlight the range of student feelings of connectedness and competency during the lockdown. Findings reaffirm that social interaction tends to support belonging and engagement, particularly for under-represented (Black or African American and Hispanic) racial groups in STEM. STEM instructors who aim to support feelings of belonging and engagement in virtual learning environments should consider increasing opportunities for student–student and student–teacher interactions, as well as taking a flexible approach that validates and integrates student voice into instruction. Future research is needed to further explore the themes of relatedness and competency that emerged as aspects of course belonging.
Integrated transcriptomic and metabolic analyses reveal that ethylene enhances peach susceptibility to Lasiodiplodia theobromae-induced gummosis

Abstract Gummosis, one of the most detrimental diseases to the peach industry worldwide, can be induced by Lasiodiplodia theobromae. Ethylene (ET) is known to trigger the production of gum exudates, but the mechanism underlying fungus-induced gummosis remains unclear. In this study, L. theobromae infection triggered the accumulation of ET and jasmonic acid (JA) but not salicylic acid (SA) in a susceptible peach variety. Gaseous ET and its biosynthetic precursor increased gum formation, whereas ET inhibitors repressed it. SA and methyl-jasmonate treatments did not influence gum formation. RNA-seq analysis indicated that L. theobromae infection and ET treatment induced a shared subset of 1808 differentially expressed genes, which were enriched in the category “starch and sucrose, UDP-sugars metabolism”. Metabolic and transcriptional profiling identified a pronounced role of ET in promoting the transformation of primary sugars (sucrose, fructose, and glucose) into UDP-sugars, which are substrates of gum polysaccharide biosynthesis. Furthermore, ethylene insensitive3-like1 (EIL1), a key transcription factor in the ET pathway, could directly target the promoters of the UDP-sugar biosynthetic genes UXS1a, UXE, RGP and MPI and activate their transcription, as revealed by firefly luciferase and yeast one-hybrid assays. On the other hand, the supply of SA and inhibitors of ET and JA decreased the lesion size. ET treatment reduced JA levels and the transcription of the JA biosynthetic gene OPR but increased the SA content and the expression of its biosynthetic gene PAL. Overall, we suggest that endogenous and exogenous ET aggravate gummosis disease by transactivating UDP-sugar metabolic genes through EIL1 and modulating JA and SA biosynthesis in L. theobromae-infected peach shoots. Our findings shed light on the molecular mechanism by which ET regulates plant defense responses in peach during L. theobromae infection.
Noniterative WLS design of digital FIR filters for aliasing errors cancellation in bandwidth interleaving digital-to-analog converter

This paper presented a noniterative weighted least squares (WLS) design of digital ﬁnite impulse response (FIR) ﬁlters for canceling the aliasing errors caused by the non-ideality of analog mixers and ﬁlters in bandwidth interleaving digital-to-analog converter (BI-DAC). Taking a BI-DAC with M sub-DACs as an example, we ﬁrstly deduced the approximation error function. Then, based on this approximation error function, the optimum coeﬃcients of all digital FIR ﬁlters were obtained by using the noniterative WLS method. Further, we deduced the computational complexity of our presented noniterative WLS design. Several design examples were given to verify the performance of our presented noniterative WLS design containing their eﬀectiveness and computational. The simulation results showed that, by using our presented noniterative WLS design, the minimum distortion error was 0.021dB, and the maximum aliasing error was -67dB which satisﬁed the desired spuriousfreedynamicrange(SFDR)ina11-bitBI-DACsystem.Finally,wecomparedthecomputationalcomplexityamongourpresentednoniterative WLSdesignandanotherthreeoptimaldesigns,andsatisfactorysimulationresultswereobtained.
PSAT1 gene as a biomarker for targeting triple negative breast cancer in presence of Rapamycin

Abstract The Triple-Negative Breast Cancers (TNBCs) poor survival outcomes are related to not responding to hormonal therapy or targeting HER2 protein. The aim of this study was to introduce a drug among the conventional chemotherapy drugs based on the transcripts of the TNBC patients. The transcriptome of MDA-MB-468 cell line as a TNBC model was analyzed in the presence of 17 common drugs in fifteen GEO datasets. Then, decreased gene lists in the presence of each drug were compared in different subtypes of breast cancer based on TCGA data. The effect of selected drug on survival and apoptosis rates of MDA-MB-468 and MCF-7 cells (as ER+/PR + model) were compared. The outcomes showed that the expression of the decreased gene by Rapamycin among other drugs increased in TNBC subtype compared to the other two subtypes including triple-positive and ER+/PR+. The expression of PSAT1 in TNBC group was significant higher than normal and other subtypes (p ≤ 0.0001), and was introduced as a biomarker in TNBC that its expression was down-regulated by Rapamycin based on in silico studies. In the presence of 3000 µg/mL Rapamycin, there was a sharp decrease in MDA-MB-468 cell viability (p ≤ 0.0001) and a significant increase in apoptosis compared to MCF-7 cells treated with the same concentration of the drug. Moreover, RT-qPCR revealed PSAT1 expression more decreased under Rapamycin-treatment in TNBC cells compared to ER + PR + cells. The results of this study show that Rapamycin is a suitable drug for targeting TNBC based on its transcriptome and biomarker. Supplemental data for this article is available online at
The Sexual and Parenting Rights of People with Physical and Psychical Disabilities: Attitudes of Italians and Socio-Demographic Factors Involved in Recognition and Denial

The sexual and parenting rights (SPRs) of people with disabilities (PwDs) are under-recognized. Sociodemographic factors may influence attitudes towards them. The aims of this study were: (1) to analyze the levels of agreement of a sample of Italian people with some SPRs of PwDs; (2) to inquire if the SPRs of people with psychical disabilities (PwPSYDs) were less recognized than those with physical disabilities (PwPHDs); (3) to verify if sociodemographic characteristics associated with under-recognition. An online anonymous survey was distributed using non-random sampling methods to conduct an inquiry into the level of agreement with statements regarding the SPRs of PwPHDs and PwPSYDs to have satisfying sexuality, to marry, and to adopt children. Answers from 973 Italian participants, aged 18–84 years (71.1% females) were analyzed. At least 70% of respondents declared in favor of the SPRs of PwPHDs. The SPRs of PwPSYDs were always subjected to higher under-recognition. Religiosity, male sex, higher age, and lower education were the factors most often associated with being against the SPRs of PwDs. Improved identification of the less tolerant respondents and the less recognized categories may allow for specific strategies for promoting the recognition of the SPRs for PwDs.