Miracle-dz/UniFAR-FTUs huggingface dataset:
Stability Analysis of Some Soybean Genotypes Using Parametric and Non Parametric Methods in Multi-Environments

Seed yields of 14 soybean genotypes were evaluated in four locations i.e. Adana, Şanlıurfa, Antalya and İzmir under second crop conditions through summer seasons from 2014 to 2016. The study aims to estimate the stability parameters in terms of seed yield of 14 soybean genotypes by using different stability analysis methods across eleven environmental conditions and to study interrelationships among these stability methods. The analysis of variance for seed yield revealed that the genotypes and the environments as well as the genotype x environment interactions (GEI) were statistically significant at P<0.01. Environmental effects were contributed 51.04% to the total sum of squares whereas GEI and genotype effects were 20.8% and 2.59%, respectively. According to most stability methods, BATEM 223, BATEM 306, BATEM 317 and KASM 02 were determined to be stable genotypes. These genotypes demonstrated superior adaptability with high yield performances in many environments. Results of correlation analysis indicated that seed yield was positively and significantly correlated with Di (P<0.01), Si (P<0.05) and TOP (P<0.01) and showed a negative and significant correlation with Pi (P<0.01) and RS (P<0.01). In addition, the coefficient of regression (bi) was positively significant associated with CVi, αi (P<0.01) and Ri (P<0.05).
Risk of Dementia in Patients Who Underwent Surgery under Neuraxial Anesthesia: A Nationwide Cohort Study

The incidence of dementia in patients with surgery under neuraxial anesthesia and the possibility of surgery under neuraxial anesthesia as a risk factor for dementia were investigated. We performed a retrospective matched cohort study with nationwide, representative cohort sample data of the Korean National Health Insurance Service in South Korea between 1 January 2003, and 31 December 2004. The participants were divided into control (n = 4488) and neuraxial groups (n = 1122) using propensity score matching. After 9 years of follow-up, the corresponding incidences of dementia were 11.5 and 14.8 cases per 1000 person-years. The risk of dementia in the surgery under neuraxial group was 1.44-fold higher (95% confidence interval [95%CI], 1.17–1.76) than that in the control group. In the subgroup analysis of dementia, the risk of Alzheimer’s disease in those who underwent surgery under neuraxial anesthesia was 1.48-fold higher (95%CI, 1.17–1.87) than that in those who did not undergo surgery under anesthesia. Our findings suggest that patients who underwent surgery under neuraxial anesthesia had a higher risk of dementia and Alzheimer’s disease than those who did not undergo surgery under neuraxial anesthesia.
Acute Respiratory Distress Syndrome and COVID-19: A Literature Review

Abstract Acute respiratory distress syndrome (ARDS) is an overwhelming inflammatory disorder of the lung due to direct and indirect insults to the lungs. ARDS is characterized by increased vascular permeability, protein-rich edema, diffuse alveolar infiltrate, and loss of aerated lung tissue, leading to decreased lung compliance, tachypnea, and severe hypoxemia. COVID-19 is generally associated with ARDS, and it has gained prime importance since it started. The mortality rate is alarmingly high in COVID-19-related ARDS patients regardless of advances in mechanical ventilation. Several pharmacological agents, including corticosteroids, nitric oxide, neuromuscular blocker, anti-TNF, statins, and exogenous surfactant, have been studied and some are under investigation, like ketoconazole, lisofylline, N-acetylcysteine, prostaglandins, prostacyclin, and fish oil. The purpose of this review is to appraise the understanding of the pathophysiology of ARDS, biomarkers, and clinical trials of pharmacological therapies of ARDS and COVID-19-related ARDS.
Liquidity Risk and Capital Structure of Companies in Latin America

Objective. To explore the relationship between liquidity risk and the capital structure of Latin American companies. Methodology. With a sample of 135 companies (Brazil, Chile and Mexico), panel data were used to analyze various models that considered, among other variables, six liquidity risk indices, two of which included a new factor: the free-float. The study period covers from 2010 to 2019. Results. The level of indebtedness and capital risk in Latin America companies present a mixed relationship (direct and inverse). Conclusions. Latin American companies have their own characteristics for decision-makingabout capital structure.
STUDIES OF THE THERMAL COMFORT INSIDE OF THE PASSENGER COMPARTMENT USING THE NUMERICAL SIMULATION

The increasing market demand for highly effective and efficient HVAC systems for automotive applications has determined a great impulse in the research and development of innovative methods and instruments to predict passengers' thermal sensation. The interaction of convective, radiation and conduction heat exchange in a passenger's compartment is very complex. The varying radiation from the sun and the influence of inhomogeneous air temperature and air velocity from the vehicle's ventilation or air conditioning system creates a climate that may vary considerably in space and time. This paper shows the distribution of the temperature and the air flow fields of passengers' compartment starting from the body's energy balance based on Fiala's manikin (which provides all the thermo-physiological effects of the human body model) by THESEUS-FE software and the numerical simulation for air flow inside the car will be acomplished by Fluent software.
B Cells in Primary Membranous Nephropathy: Escape from Immune Tolerance and Implications for Patient Management

Membranous nephropathy (MN) is an important cause of nephrotic syndrome and chronic kidney disease (CKD) in adults. The pathogenic significance of B cells in MN is increasingly recognized, especially following the discovery of various autoantibodies that target specific podocytic antigens and the promising treatment responses seen with B cell depleting therapies. The presence of autoreactive B cells and autoantibodies that bind to antigens on podocyte surfaces are characteristic features of MN, and are the result of breaches in central and peripheral tolerance of B lymphocytes. These perturbations in B cell tolerance include altered B lymphocyte subsets, dysregulation of genes that govern immunoglobulin production, aberrant somatic hypermutation and co-stimulatory signalling, abnormal expression of B cell-related cytokines, and increased B cell infiltrates and organized tertiary lymphoid structures within the kidneys. An understanding of the role of B cell tolerance and homeostasis may have important implications for patient management in MN, as conventional immunosuppressive treatments and novel B cell-targeted therapies show distinct effects on proliferation, differentiation and reconstitution in different B cell subsets. Circulating B lymphocytes and related cytokines may serve as potential biomarkers for treatment selection, monitoring of therapeutic response and prediction of disease relapse. These recent advances in the understanding of B cell tolerance in MN have provided greater insight into its immunopathogenesis and potential novel strategies for disease monitoring and treatment.
Urgent issues and prospects at the intersection of culture, memory, and witness interviews: Exploring the challenges for research and practice

The pursuit of justice increasingly relies on productive interactions between witnesses and investigators from diverse cultural backgrounds during investigative interviews. To date, the role of cultural context has largely been ignored by researchers in the field of investigative interviewing, despite repeated requests from practitioners and policymakers for evidence- based guidance for the conduct of interviews with people from different cultures. Through examining cultural differences in human memory and communication and considering specific contextual challenges for investigative interviewing through the lens of culture, this review and associated commentaries highlight the scope for considering culture and human diversity in research on, and the practice of, investigative interviewing with victims, witnesses, and other sources. Across 11 commentaries, contributors highlight the importance of considering the role of culture in suggestibility, of the interview, potential for miscommunication. Work to focus on evidence - based to these challenges. We two
Comparison of Volatile Organic Compound Concentrations in Ambient Air among Different Source Areas around Khon Kaen, Thailand

Volatile organic compounds (VOCs) are a complex group of chemicals that pose a direct risk to human health. They also lead to the formation of other air pollution constituents, including fine particulate matter (PM2.5) and ground level ozone (O₃). The ambient air concentrations of 19 VOCs were measured using multi-day 24 h sampling at two urban sites and two rural sites in the area of Khon Kaen, Thailand. Results showed that most VOCs were at concentrations considered acceptable according to the 24 h average standards established by the Thai Pollution Control Department. The VOC acrolein, however, was detected at concentrations (0.69–1.15 μg/m3) in excess of the 24 h average standard (0.55 μg/m3). Two other VOCs, benzene and 1,3-butadiene, were also detected at elevated levels (1.73–2.75 and 0.18–0.40 μg/m3, respectively) that indicated the potential to exceed the 1-year average standard. VOC concentrations were highest in the urban market monitoring site, suggesting that vehicle exhaust and food preparation using cooking oil at high temperatures may have been potential sources of the elevated VOCs.
Effect of Soil-Applied L-tryptophan on the Amount of Biomass and Nitrogen and Sulfur Utilization by Maize

As natural plant growth stimulators, amino acids are widely used to improve crop yield and quality. There are numerous studies documenting the influence of amino acids on plants, which is not always positive. This study was conducted to determine the effect of soil-applied L-tryptophan (L-TRP) on the accumulation and utilization of nitrogen and sulfur by maize. The study was carried out under the conditions of a pot experiment. The experimental design included three treatments: soil without fertilization (control), soil with mineral fertilization (NPKS), and soil with mineral fertilization and L-tryptophan addition (NPKS + L-TRP). The application of tryptophan to the soil, supported by mineral fertilization, caused a significant increase in maize biomass. Although no significant differences in nitrogen and sulfur contents in maize biomass were found between treatments without and with the addition of L-tryptophan, significantly higher intakes of both elements were observed in the NPKS + L-TRP treatment. The application of L-tryptophan increased the biosynthesis of Chlorophyll a. Utilization of nitrogen and sulfur by maize in the NPKS + L-TRP treatment was more than 27% and 17% higher, respectively, compared to the NPKS treatment. Maintaining the recommended contents of individual nutrients in the rhizosphere is not a guarantee of optimal quantitative and qualitative intake of nutrients. Problems with maintaining optimal relationships between individual nutrients may be compounded by soil properties.
Assessing Post-Fire Effects on Soil Loss Combining Burn Severity and Advanced Erosion Modeling in Malesina, Central Greece

Earth’s ecosystems are extremely valuable to humanity, playing a key role ecologically, economically, and socially. Wildfires constitute a significant threat to the environment, especially in vulnerable ecosystems, such as those that are commonly found in the Mediterranean. Due to their strong impact on the environment, they provide a crucial factor in managing ecosystems behavior, causing dramatic modifications to land surface processes dynamics leading to land degradation. The soil erosion phenomenon downgrades soil quality in ecosystems and reduces land productivity. Thus, it is imperative to implement advanced erosion prediction models to assess fire effects on soil characteristics. This study focuses on examining the wildfire case that burned 30 km2 in Malesina of Central Greece in 2014. The added value of remote sensing today, such as the high accuracy of satellite data, has contributed to visualizing the burned area concerning the severity of the event. Additional data from local weather stations were used to quantify soil loss on a seasonal basis using RUSLE modeling before and after the wildfire. Results of this study revealed that there is a remarkable variety of high soil loss values, especially in winter periods. More particularly, there was a 30% soil loss rise one year after the wildfire, while five years after the event, an almost double reduction was observed. In specific areas with high soil erosion values, infrastructure works were carried out validating the applied methodology. The approach adopted in this study underlines the significance of using remote sensing and geoinformation techniques to assess the post-fire effects of identifying vulnerable areas based on soil erosion parameters on a local scale.
The Strength of Glued Joints

WITHIN the last year or so we have learned to glue metals together with a strength which brings this method of joining materials into competition with riveting, at least in the thin gauges used in the aircraft and motor industries. Apart from this new extension of gluing to the metal working trades synthetic adhesives have already revolutionized the woodworking industries. This revolution is due to the superior quality of the resulting products and the increased rate of output made possible by the intrinsic high speed of setting of synthetic adhesives aided by such novel methods as high frequency heating, infra‐red heating and the like. In aircraft in particular the “weather‐resistance” of synthetic adhesives has largely removed the disadvantages of wood construction, due to the use of casein glues, so much in evidence in the first winter of this war. It may be said therefore that gluing has been raised from the status of a useful but humble convenience of daily life to a process of engineering significance. But before engineers can use gluing in the fabrication of structures they must be provided with data sufficient to enable thorn to compute the strength of the joints, and we at Aero Research Ltd. have therefore endeavoured to find a simple relation between the strength of a lap joint and its geometry. Such a simple relation is found in “the joint factor” which is defined3 as the square root of the thickness of the sheet divided by the length of the overlap.
β-Hydroxy-β-Methylbutyrate Supplementation Promotes Antitumor Immunity in an Obesity Responsive Mouse Model of Pancreatic Ductal Adenocarcinoma

Simple Summary Pancreatic cancer (PDAC) is a deadly disease, exacerbated by obesity, which lacks effective therapeutic interventions. Most PDAC has a limited response to immune- and chemotherapy. Treating PDAC is made additionally challenging by the rapid emergence of muscle wasting and cachexia, which predict poor response to several therapies. We have found that dietary supplementation with β-hydroxy-β-methylbutyrate promotes immunosurveillance in PDAC tumors and protects muscle. This dietary supplement has the potential to be an important adjuvant in PDAC therapy, opening the doors to immunotherapy response. Abstract Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths in the United States, and effective therapies for PDAC are currently lacking. Moreover, PDAC is promoted and exacerbated by obesity, while cachexia and sarcopenia are exceptionally common comorbidities that predict both poor survival and treatment response. Managing PDAC with immunotherapies has thus far proven ineffective, partly due to the metabolically hostile tumor microenvironment. β-hydroxy-β-methylbutyrate (HMB), a metabolite of leucine commonly used as a dietary supplement to boost muscle growth and immune function, may be an attractive candidate to augment PDAC therapy. We therefore sought to test the hypothesis that HMB would enhance antitumor immunity while protecting mouse muscle mass. Control and diet-induced obese C57BL/6 male mice bearing subcutaneously injected Panc02 tumors were supplemented with 1% HMB and treated with or without 50 mg/kg gemcitabine (n = 15/group). HMB was associated with reduced muscle inflammation and increased muscle fiber size. HMB also reduced tumor growth and promoted antitumor immunity in obese, but not lean, mice, independent of the gemcitabine treatment. Separately, in lean tumor-bearing mice, HMB supplementation promoted an anti-PD1 immunotherapy response (n = 15/group). Digital cytometry implicated the decreased abundance of M2-like macrophages in PDAC tumors, an effect that was enhanced by anti-PD1 immunotherapy. We confirmed that HMB augments M1-like macrophage (antitumor) polarization. These preclinical findings suggest that HMB has muscle-sparing and antitumor activities against PDAC in the context of obesity, and that it may sensitize otherwise nonresponsive PDAC to immunotherapy.
Correlation between the Mandibular Lingula Position and Some Anatomical Landmarks in Cone Beam CT

Background: the position of the mandibular lingula (Li) affects the success rate of the inferior alveolar nerve block (IANB) and ramus osteotomies. This study evaluated the position of the Li, to investigate the anatomical relationship between the Li and some anatomical measurements using cone beam computed tomography (CBCT). Methods: 201 hemimandibular CBCTs of 111 patients (43 males and 68 females; 18 to 88 years old) were retrospectively evaluated. The Li location was determined from the lingula tip to: the occlusal plane, the anterior and posterior borders of the mandibular ramus, the lower border of the mandible, the distal surface of the mandibular second molar, and the mandibular notch. We evaluated the correlations between the Li and the anteroposterior diameter of the mandibular ramus; the vertical distance between condyle and mandibular angle; the mesial–distal diameter of the first, second, and third mandibular molar, the intercanine distance, the intermolar distances among the first, second, and third mandibular molars; the distance between the intermolar line of the first molar and midline, and the length of the mandibular body. Results: the vertical distance of the Li from the occlusal plane was 11.22 ± 4.27 mm. Some parameters significantly correlated with the anatomical measurements taken into consideration. Conclusions: the present study provides new information concerning the Li and mandibular anatomy in the Italian population. Moreover, by correlating some anatomic measurements to the Li position, the localization of the Li is made possible, indirectly through the measurement of some distances between anatomical landmarks.
Quasi‐biennial oscillation impacts on Madden–Julian oscillation‐associated tropical–extratropical interactions and Kelvin waves

Several recent works have demonstrated that the Madden–Julian oscillation (MJO) shows more variance in tropical convection and wind during the easterly phase of stratospheric wind in the quasi‐biennial oscillation (QBO). Some of these works have shown that reduced variance during the westerly QBO is associated with fewer repeating cycles of events. This article applies a modulation linear regression algorithm to assess changes in the global atmospheric circulation structure for December–February MJO signals tested when time‐smoothed 50 hPa winds are easterly or westerly at 10 m·s−1. Results show pronounced differences in the associated extratropical upper tropospheric Rossby wave response between the two QBO states, along with a comparatively lower fraction of total eastward wave energy being consistent with Kelvin waves approaching the Indian basin from the west during the westerly QBO. Instead, westerly QBO appears to favour stronger equatorward‐moving extratropical wave precursors across the Western Hemisphere and Eurasia. The results suggest the hypothesis that more dependence on extratropical waves during the westerly QBO may reduce the reliability of the MJO to form sequential trains during the westerly QBO.
Natural variation in stomatal dynamics drives divergence in heat stress tolerance and contributes to the seasonal intrinsic water-use efficiency in Vitis vinifera (subsp. sativa and sylvestris).

Stomata control CO2 uptake for photosynthesis and water loss through transpiration, thus playing a key role in leaf thermoregulation, water-use efficiency (iWUE) and plant productivity. In this work, we investigated the relationship between several leaf traits and hypothesized that stomatal behavior to fast (i.e. minutes) environmental changes co-determines along with steady-state traits the physiological response of grapevine to the surrounding fluctuating environment over the growing season. No relationship between iWUE, heat stress (HS) tolerance and stomatal traits was observed in field grown grapevine, suggesting that other physiological mechanisms are involved in determining leaf evaporative cooling capacity and the seasonal ratio of CO2 uptake (A) to stomatal conductance (gs). Indeed, cultivars that in the field had an unexpected combination of high iWUE but low sensitivity to thermal stress, displayed a quick stomatal closure to light, but a sluggish closure to increased vapor pressure deficit (VPD) levels. This strategy aiming both at conserving water under a high-to-low light transition and in prioritizing evaporative cooling under a low-to-high VPD transition, was mainly observed in Regina and Syrah. Moreover, cultivars with different known responses to soil moisture deficit or high air VPD (isohydric vs anisohydric) had opposite behavior under fluctuating environments, with the isohydric cultivar showing slow stomatal closure to reduced light intensity but quick temporal responses to VPD manipulation. We propose that stomatal behavior to fast environmental fluctuations can play a critical role on leaf thermoregulation and water conservation under natural field conditions in grapevine.
A Pilot Survey of Odontomas for Size Constancy Using Cone-Beam Computed Tomography: Effect of Age, Sex, Lesion Location, and Histological Type: A Case Series

Objectives: Odontoma is the most common type of odontogenic tumors. Many studies have analyzed the statistical associations between odontoma location and patient age and sex, according to the histological tumor type. However, few studies have assessed odontoma morphological characteristics using cone-beam computed tomography (CBCT). We aimed to evaluate the association between odontoma location and size. Methods: We performed CBCT on patients with odontomas (19 patients; 10 women, 9 men; average age, 12.6 [range, 6 - 34] years) according to the pathology type at a university hospital between April 2008 and February 2017. The locations of the lesions were noted, and their sizes were measured on CBCT images. Buccolingual, mesiodistal, and vertical diameters of the lesions were recorded on the same slice with the greatest diameters on axial, coronal, and sagittal CBCT images. Results: Altogether, 9 (47.4%) and 10 (52.6%) odontomas were located in the mandible and maxilla, respectively. There was no significant difference in the mesiodistal and vertical diameters on the CBCT image between the mandibular and maxillary groups when the odontoma size was compared with location (p < 0.05). However, the average diameters in only the buccolingual diameter