Miracle-dz/UniFAR-FTUs huggingface dataset:
Pre- vs. Post-National Coverage Determination (NCD) Blood Utilization and Hemoglobin Values among Medicare Patients Treated with Erythropoietic-Stimulating Agents (ESAs) for Chemotherapy-Induced Anemia (CIA)

Background: In July 2007, the Centers for Medicare and Medicaid Services issued ESA coverage limitations for cancer patients with CIA through a national coverage determination (NCD). Clinical outcomes based on ESA dosing described in the NCD have not been reported in prospective observational or clinical trial data. To understand hematologic outcomes in the Medicare population treated in pre- and post-NCD time period, an analysis of hematologic outcomes from the DOSE (Dosing and Outcomes Study of Erythropoiesis-Stimulating Therapies) registry, an ongoing prospective observational study, was conducted. Methods: ESA-treated cancer patients with CIA were selected based on Medicare primary coverage, available baseline hemoglobin (Hb) value, and receipt of at least two ESA administrations. Data were categorized into two timeframes based on date of initial ESA administration: pre-NCD (4/06-4/07) and post-NCD (10/07-5/08). Baseline demographics, Hb values during ESA treatment, and blood utilization patterns were analyzed. Results: 288 patients were identified (Pre-NCD – 230; Post-NCD – 58) from 41 sites. Patient groups were similar with respect to age, gender, weight, and tumor type. ESA treatment duration was significantly greater in the pre-NCD group (70 days vs. 54 days, p = 0.0011). As shown in the table, differences with regard to blood utilization and Hb values were observed between the Pre-NCD and Post-NCD populations. A significantly greater proportion of patients required a blood transfusion and the number of units administered per study patient was significantly higher in the Post-NCD group. Hb levels were significantly lower at all time points of observation in the Post-NCD group. Conclusion: Greater blood utilization and lower Hb values were observed in Medicare CIA patients treated with ESAs during the Post-NCD time period compared to the Pre- NCD time period. The impact of the NCD on patient outcomes is important to providers and hospital systems and warrants further research.
BERT and fastText Embeddings for Automatic Detection of Toxic Speech

With the expansion of Internet usage, catering to the dissemination of thoughts and expressions of an individual, there has been an immense increase in the spread of online hate speech. Social media, community forums, discussion platforms are few examples of common playground of online discussions where people are freely allowed to communicate. However, the freedom of speech may be misused by some people by arguing aggressively, offending others and spreading verbal violence. As there is no clear distinction between the terms offensive, abusive, hate and toxic speech, in this paper we consider the above mentioned terms as toxic speech. In many countries, online toxic speech is punishable by the law. Thus, it is important to automatically detect and remove toxic speech from online medias. Through this work, we propose automatic classification of toxic speech using embedding representations of words and deep-learning techniques. We perform binary and multi-class classification using a Twitter corpus and study two approaches: (a) a method which consists in extracting of word embeddings and then using a DNN classifier; (b) fine-tuning the pre-trained BERT model. We observed that BERT fine-tuning performed much better. Proposed methodology can be used for any other type of social media comments.
English as a Foreign Language Learner Interactions with Chatbots: Negotiation for Meaning.

Chatbots, whose potential for language learning have caused controversy among Second Language Acquisition (SLA) researchers (Atwell, 1999; Fryer & Carpenter, 2006; Fryer & Nakao, 2009; Parker, 2005, Coniam, 2014; Jia, 2004; Chantarotwong, 2005) are intelligent conversational systems stimulating human interlocutors with voice or text. In this paper, two different types of chatbots (pedagogical chatbot Tutor Mike and conversational chatbot Mitsuku) were selected to investigate their potential for foreign language learning by exploring the frequency and patterns of Negotiation for Meaning (NfM) in CMC interactions. 8 Chinese EFL leaners were randomly divided into two groups (lower and higher-level learners), and all learners interacted with both the pedagogical and conversational chatbot in a switching replications research design. Data were analysed through content analysis to identify the number of NfM instances observed, the different stages of NfM, trigger types, modified output and learners’ perceptions. The findings of this study indicate that while learners with low language levels would benefit most from interactions with pedagogical agents, high language level learners expressed dissatisfaction with chatbots and a low level of engagement was observed in their interactions with the pedagogical chatbot.
The efficacy of antibiotic therapy, with or without teat seals, during the dry period in the treatment and prevention of mastitis in Irish dairy cows

THEEFFICACY OF ANTIBIOTIC THERARY, WITH OR WITHOUT TEAT SEALS, DURING THE DRY PERIOD IN THE TREATMENT AND PREVENTION OF MASTITIS IN IRISH DAIRY HERDS. W.J. Meaney This thesis reports on the efficacy of antibiotic and non-antibiotic intramammary formulations for the treatment and prevention of mastitis during the dry period. Survey data on the types of pathogens causing mastitis at drying off and the resposes to treatment are also reported. The efficacy of seven intramammary antibiotics which were formulated for the treatment of cows at drying off was evaluated. The products were tested primarily on their ability to eliminate Staph. aureus infections. The elimination of Staph. aureus ranged from 25 per cent to 94 per cent and in general there was no difference in efficacy between products. There was a significant benefit (P<0.001) in treating Staph. aureus infections with benzathine cloxacillin when compared with no therapy at drying off. There was no advantage in treating Staph. aureus with benzathine cloxacillin on two occasions during the dry period. The efficacy of a long-acting formulation containing neomycin sulphate in preventing new dry period mastitis was evaluated in uninfected cows at drying off. At the next calving there were fewer new infections in the treated quarters than in the untreated quarters (P<0.001). The effectiveness of a bismuth subnitrate teat-sealer was evaluated in a series of eight experiments. The sealer was evaluated primarily on its ability to prevent new infections in cows during the dry period. In two out of three experiments, teat-sealers used in combination with antibiotics were more effective (P<0.005; P<0.05) in preventing new infections than antibiotics alone. In one experiment, an oil-based antibiotic used in combination with teat-sealer was more effective (P<0.05) than the antibiotic alone in eliminating infections at drying off. When sealed and untreated quarters were challenged with cultures of Staph. aureus and Strep. dysgalactiae during the dry period the sealer was more effective (P<0.05) in reducing new infections. The results of a second challenge experiment using Staph. aureus showed that there was no difference in the level of new infection during the dry period between quarters which were sealed or infused with benzathine cloxacillin at drying off. One experiment was undertaken to evaluate the effectiveness of sealing the teats of in-calf heifers at intervals ranging from 9 to 110 days before calving. There was no difference in the level of infection at calving in the sealed teats and untreated teats. Surveys carried out between 1984-1992 showed that 94 per cent of intramammary infections diagnosed at drying off were caused by staphylococci and streptococci. Between 48 and 72 per cent of Staph, aureus infections were eliminated following dry period antibiotic treatment. Antibiotic therapy was more effective (P<0.001) in eliminating Staph. aureus infections in first or second lactation animals than in older animals.
Pharmacogenetic approach to clopidogrel resistance: recurrent stent thrombosis in two brother

Clopidogrel, is the antiplatelet treatment choice for prevention of thrombosis after coronary stent implantation. However, despite the use of clopidogrel, a considerable number of patients continue to have stent thrombosis. There is a growing degree of evidence that recurrence of ischemic complications may be attributed to poor response of clopidogrel. It is noteworthy to elucidate the mechanisms leading to poor clopidogrel effects. We reportrecurrent stent thrombosiswith possible clopidogrel resistanceand aimed to discuss the mechanisms of clopidogrel resistance in the light of the medical literature.
Effect of Exogenous Protease, Mannanase, and Xylanase Supplementation in Corn and High Protein Corn DDGS Based Diets on Growth Performance, Intestinal Morphology and Nutrient Digestibility in Broiler Chickens

A study was conducted to evaluate the effects of exogenous enzymes supplementation in high protein (Hi-Pro) corn DDGS-based diets on broiler growth performance, intestinal health, and nutrient digestibility. A total of 200 one-day-old broiler chicks were randomly allocated to four dietary treatments with five replicates of 10 birds each. A basal diet (CON) was formulated (CP: 20%; ME: 2900 Kcal/kg) containing 15% of dietary crude protein share from Hi-Pro corn DDGS. Three experimental diets were developed using basal diets; diet one was supplemented with protease (CON-P), diet two with an enzyme mix of mannanase and xylanase (CON-MX) and diet three with a protease and enzyme mix of mannanase and xylanase. A digestibility assay was carried out using Celite (insoluble acid ash), from day 29 to day 35. On day 35, four birds from each replicate were picked randomly and killed by cervical dislocation to collect ileal digesta. In addition, duodenum, jejunum and ileum lengths were measured, and tissue samples were collected from midpoints of jejunum to note villus height and crypt depths. Feed intake, body weight gain and feed conversion ratio were not affected by dietary treatments during the entire study period (p>0.05). Likewise, no difference in carcass characteristics, soft organ weight, intestinal morphology, apparent amino acids digestibility and visible ileal digestible energy was observed by the dietary treatments (p>0.05). Supplementation of exogenous protease and enzyme mix (mannanase and xylanase) had no effect on growth performance, intestinal integrity and nutrient availability of broiler chickens fed HiPro DDGS-based diets.
Investigating the role of GNL3 in osteoarthritis

presentation: Genetics of Osteoarthritis at The SNP Course VII 2010, The Erasmus Postgraduate School Molecular Medicine, Rotterdam Poster presentation: Investigating the Role of GNL3 in Osteoarthritis at TreatOA Summer School 2011, Harris Manchester College, Oxford Poster presentation: Investigating the Role of GNL3 in Osteoarthritis at Osteoarthritis Research Society International (OARSI) Conference 2012, Barcelona Presentation: Genetics of Osteoarthritis as part of the Overcoming Osteoarthritis Event at Edinburgh International Science Festival 2012, Edinburgh
Comparative genomic analysis revealed specific mutation pattern between human coronavirus SARS-CoV-2 and Bat-SARSr-CoV RaTG13

The novel coronavirus SARS-CoV-2 (2019-nCoV) is a member of the family coronaviridae and contains a single-stranded RNA genome with positive-polarity. To reveal the evolution mechanism of SARS-CoV-2 genome, we performed comprehensive genomic analysis with newly sequenced SARS-CoV-2 strains and 20 closely related coronavirus strains. Among 98 nucleotide mutations at 93 sites of the genome among different SARS-CoV-2 strains, 58 of them caused amino acid change, indicating a result of neutral evolution. However, the ratio of nucleotide substitutions to amino acid substitutions of spike gene (9.07) between SARS-CoV-2 WIV04 and Bat-SARSr-CoV RaTG13 was extensively higher than those from comparisons between other coronaviruses (range 1.29 - 4.81). The elevated synonymous mutations between SARS-CoV-2 and RaTG13, suggesting they underwent stronger purifying selection. Moreover, their nucleotide substitutions are enriched with T:C transition, which is consistent with the mutation signature caused by deactivity of RNA 3’-to-5’ exoribonuclease (ExoN). The codon usage was similar between SARS-CoV-2 and other strains in beta-coronavirus lineage B, suggesting it had small impact on the mutation pattern. In comparison of SARS-CoV-2 WIV04 with Bat-SARSr-CoV RaTG13, the ratios of non-synonymous to synonymous substitution rates (dN/dS) was the lowest among all performed comparisons, reconfirming the evolution of SARS-CoV-2 under stringent selective pressure. Moreover, some sites of spike protein might be subjected to positive selection. Therefore, our results will help understanding the evolutionary mechanisms contribute to viral pathogenicity and its adaptation with hosts.
Combinatorial Sleeping Bandits With Fairness Constraints

The multi-armed bandit (MAB) model has been widely adopted for studying many practical optimization problems (network resource allocation, ad placement, crowdsourcing, etc.) with unknown parameters. The goal of the player (i.e., the decision maker) here is to maximize the cumulative reward in the face of uncertainty. However, the basic MAB model neglects several important factors of the system in many real-world applications, where multiple arms (i.e., actions) can be simultaneously played and an arm could sometimes be “sleeping” (i.e., unavailable). Besides reward maximization, ensuring <italic>fairness</italic> is also a key design concern in practice. To that end, we propose a new <italic>Combinatorial Sleeping MAB model with Fairness constraints</italic>, called <italic>CSMAB-F</italic>, aiming to address the aforementioned crucial modeling issues. The objective is now to maximize the reward while satisfying the fairness requirement of a minimum selection fraction for each individual arm. To tackle this new problem, we extend an online learning algorithm, called <italic>Upper Confidence Bound (UCB)</italic>, to deal with a critical tradeoff between <italic>exploitation</italic> and <italic>exploration</italic> and employ the virtual queue technique to properly handle the fairness constraints. By carefully integrating these two techniques, we develop a new algorithm, called <italic>Learning with Fairness Guarantee (LFG)</italic>, for the CSMAB-F problem. Further, we rigorously prove that not only LFG is <italic>feasibility-optimal</italic>, but it also has a time-average <italic>regret</italic> upper bounded by <inline-formula><tex-math notation="LaTeX">$\frac{N}{2 \eta } + \frac{\beta _1 \sqrt{m N T \log {T}}+ \beta _2~N}{T}$</tex-math></inline-formula>, where <inline-formula><tex-math notation="LaTeX">$N$</tex-math></inline-formula> is the total number of arms, <inline-formula><tex-math notation="LaTeX">$m$</tex-math></inline-formula> is the maximum number of arms that can be simultaneously played, <inline-formula><tex-math notation="LaTeX">$T$</tex-math></inline-formula> is the time horizon, <inline-formula><tex-math notation="LaTeX">$\beta _1$</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">$\beta _2$</tex-math></inline-formula> are constants, and <inline-formula><tex-math notation="LaTeX">$\eta$</tex-math></inline-formula> is a design parameter that we can tune. Finally, we perform extensive simulations to corroborate the effectiveness of the proposed algorithm. Interestingly, the simulation results reveal an important tradeoff between the regret and the speed of convergence to a point satisfying the fairness constraints.
Sustainability Strategy and Service Quality Innovativeness of Manufacturing Firms in Ogun State

The essence of this study is to examine the relationship between sustainability strategy and service quality innovativeness of manufacturing firms in Ogun State.Four objectives, research questions and hypotheses were postulated in order to find to get close to the unknown of the study. Two hundred and sixty-six senior personnel and distributors formed the sample size from thirty-eight (38) manufacturing firms. A self-designed instrument was used for the collection of primary data andPearson Product Moment Correlation (PPMC) was the statistical tool used in analysing the primary data. From the findings of the study it was revealed that there is relationship between sustainability strategy and service quality innovativeness in manufacturing firms in Ogun State. Based on the findings, it was recommended thatmanufacturing firms should keep to the strategic rules of being not easy to imitate, heterogeneity, unique and rare, etc., to enjoy the full benefit of sustainability strategy in the industry. Again, serious caution should be exercise in adopting more than one sustainability strategies at the same time.
Les anomalies de l'hemoglobine au centre hospitalier universitaire de Lome, Togo

○ Le Togo, pays d'Afrique subsaharienne, est confronte a plusieurs problemes de sante publique notamment les endemies tropicales. Il est, par ailleurs, situe dans la ceinture sicklemique de Lehmann et les anomalies genetiques du globule rouge y sont frequentes. Cette etude a pour objectif de recenser les principales hemoglobinopathies, leur frequence relative et de preciser certaines difficultes diagnostiques a partir de 3 etudes portant sur 5604 sujets. La premiere, prospective, concernait 405 patients de rhumatologie; la deuxieme, retrospective, analysait 5028 electrophoreses de l'hemoglobine et la derniere etait une etude transversale de 171 nouveau-nes des trois principales maternites de la ville de Lome. La technique de base d'etude de l'hemoglobine etait l'electrophorese a pH alcalin et l'identification des hemoglobines rares fut effectuee au laboratoire de Biochimie de l'hopital Henri Mondor (Creteil). Le diagnostic d'a-thalassemie a ete fait par PCR. Les anomalies de l'hemoglobine sont dominees par les hemoglobines S et C avec des frequences respectives de 15,8 a 16,7 % pour le trait AS; 12,1 a 15,8 % pour le trait AC. La forme homozygote representait 1,2 a 2 % des sujets et la forme double heterozygote 2,3 a 4,2 %. Les hemoglobines rares concernaient les hemoglobines rapides, l'hemoglobine D et la persistance hereditaire de l'hemoglobine F. L'a- thalassemie a concerne 47 % des 171 nouveau-nes etudies avec une predominance de la forme heterozygote (38,6 %) suivie de la forme homozygote (8 %). Une triplication a a ete identifiee chez 2,4 % des nouveau-nes. La presence d'hemoglobine Bart's n'atteste pas forcement l'existence d'une α-thalassemie. Elle a ete retrouvee chez 15 nouveau-nes (8,8 %) ayant un genotype a normal et elle etait absente chez 10 nouveau-nes heterozygotes (5,9 %). Cette etude montre que la biologie moleculaire constitue la methode de choix du diagnostic des anomalies des genes α-globine.
KUALITAS LAYANAN, KEPUASAN NASABAH, LOKASI PERUSAHAAN DAN LOYALITAS KONSUMEN

Kompetisi bisnis dalam alaf globalisasi ini menuntut suatu korporasi mampu merespon dengan keputusan yang cepat dan tepat. Oleh karena itu, setiap perusahaan dituntut bersaing secara kompetitif dalam hal menciptakan dan mempertahankan konsumen yang loyal. Tujuan penelitian ini adalah mengetahui pengaruh kualitas pelayanan, kepuasan nasabah dan lokasi terhadap loyalitas nasabah baik secara parsial maupun simultan serta untuk mengetahui variabel manakah yang paling berpengaruh terhadap loyalitas nasabah BMT Tumang Cabang Grabag Magelang.Tipe penelitian dalam penelitian ini adalah penelitian ekslanatory dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah seluruh nasabah BMT Tumang Cabang Grabag Magelang per Juni 2018 yang berjumlah 886 nasabah. jumlah sampel yang digunakan dalam penelitian ini adalah berjumlah 89 responden yang diambil secara accidental sampling. Teknik analisis data menggunakan analisis regresi linier berganda pada taraf signifikansi 5%. Hasil penelitian menunjukan terdapat pengaruh yang signifikan kualitas pelayanan, kepuasan nasabah, dan lokasi terhadap loyalitas nasabah BMT Tumang Cabang Grabag Magelang baik secara simultan maupun parsial terhadap loyalitas nasabah, dengan variabel kualitas pelayanan mempunyai pengaruh paling dominan terhadap loyalitas nasabah
Real-Time Catheter Tracking and Adaptive Imaging for Interventional Cardiovascular MRI

12 CHAPTER I: INTRODUCTION . 14 1.1 SIGNIFICANCE . 14 1.2 ATHEROSCLEROTIC PLAQUE . 15 1.2. 1 Disease Definition. 15 1.2. 2 Disease Diagnosis. 17 1.2. 3 Disease Treatment . 22 1.3 IMAGE GUIDED CATHETER-BASED INTERVENTIONS: X-RAY VERSUS MRI . 23 1.4 CATHETER TRACKING USING MRI . 25 1.5 OVERVIEW OF DISSERTATION . 29 1.5. 1 General Hypothesis. 29 1.5. 2 Localization of Tracking Markers in MR. 30 1.5. 3 Adaptive Image Parameter System . 30 1.5. 4 Clinical Evaluation of iMRI System. 30 1.5. 5 Respiratory Motion Compensation for AR Surgical System. 31
Comment on “The Impact of Recent Forcing and Ocean Heat Uptake Data on Estimates of Climate Sensitivity”

In 2018, Lewis and Curry presented a method for estimating the transient climate response (TCR) of the climate system from the temperature change between two time windows: an early baseline period in the nineteenth century and a modern period primarily in the twenty-first century. The results suggest a lower value of TCR than estimates from climate model simulations. Previous studies have identified uncertainty in the historical forcings, the impact of the time evolution of the forcing on temperature response, and observational issues as contributory factors to this disagreement. We investigate a further factor: uncertainty in the bias corrections applied to historical sea surface temperature data. This uncertainty can particularly affect the estimation of variables on decadal time scales and therefore affect the estimation of TCR using the window method as well as estimates of internal variability. We demonstrate that use of the whole historical record can mitigate the impacts of working with short time windows to some extent, particularly with respect to the early part of the record.