Miracle-dz/UniFAR-FTUs huggingface dataset:
Sparse Channel Estimation for Massive MIMO System Based on Dirichlet Process and Combined Message Passing

This paper investigate the problem of estimating sparse channels in massive MIMO systems. Most wireless channel are sparse with large delay spread, while some channels can be observed have sparse common support (SCS) within a certain area of the antenna array. This SCS property is attractive when it comes to the estimation of large number of channels in massive MIMO systems. In this paper, we proposed a novel channel estimation approach which utilize the SCS by exerting a Dirichlet process (DP) prior over the sparse Bayesian learning (SBL) model. In addition, this Dirichlet process is modeled based on factor graph and combined belief propagation (BP) and mean field (MF) message passing. Compared to the variational Bayesian (VB) based method in literature, the method proposed in this paper can improve the performance while significantly reduce the complexity. Simulation results demonstrate that the proposed algorithm outperform other reported ones in both performance and complexity.
Evaluating synteny for improved comparative studies

Motivation: Comparative genomics aims to understand the structure and function of genomes by translating knowledge gained about some genomes to the object of study. Early approaches used pairwise comparisons, but today researchers are attempting to leverage the larger potential of multi-way comparisons. Comparative genomics relies on the structuring of genomes into syntenic blocks: blocks of sequence that exhibit conserved features across the genomes. Syntenic blocs are required for complex computations to scale to the billions of nucleotides present in many genomes; they enable comparisons across broad ranges of genomes because they filter out much of the individual variability; they highlight candidate regions for in-depth studies; and they facilitate whole-genome comparisons through visualization tools. However, the concept of syntenic block remains loosely defined. Tools for the identification of syntenic blocks yield quite different results, thereby preventing a systematic assessment of the next steps in an analysis. Current tools do not include measurable quality objectives and thus cannot be benchmarked against themselves. Comparisons among tools have also been neglected—what few results are given use superficial measures unrelated to quality or consistency. Results: We present a theoretical model as well as an experimental basis for comparing syntenic blocks and thus also for improving or designing tools for the identification of syntenic blocks. We illustrate the application of the model and the measures by applying them to syntenic blocks produced by three different contemporary tools (DRIMM-Synteny, i-ADHoRe and Cyntenator) on a dataset of eight yeast genomes. Our findings highlight the need for a well founded, systematic approach to the decomposition of genomes into syntenic blocks. Our experiments demonstrate widely divergent results among these tools, throwing into question the robustness of the basic approach in comparative genomics. We have taken the first step towards a formal approach to the construction of syntenic blocks by developing a simple quality criterion based on sound evolutionary principles. Contact: cristinagabriela.ghiurcuta@epfl.ch
Partial replacement of grass silage with faba bean whole-crop silage in the diet of dairy cows

Grain legumes are an interesting alternative to grass as cattle forage owing to their nitrogen fixing ability and high biomass production. The objective of this study was to investigate the effect of a mixture of grass silage and faba bean-spring wheat (Vicia faba – Triticum aestivum) whole-crop silage (FB) on feed intake, nutrient utilization and milk production of dairy cows. Eight multiparous Finnish Ayrshire cows averaging 100 d in milk and producing 45 kg d-1 milk were used in a replicated 4×4 Latin square study. Experimental treatments consisted of timothy-meadow fescue (Phleum pratense – Festuca pratensis) silage (GS) and a mixture of GS and FB (1:1 on a dry matter (DM) basis). Both forages were fed ad libitum and supplemented with 13 kg d-1 of concentrate containing 2.0 or 3.5 kg rape seed meal (RSM). The crude protein content of the concentrate was 175 or 200 g kg-1 DM, respectively. Replacing half of the GS with FB maintained silage DM intake and milk yield despite the lower digestibility of FB silage. Increasing RSM in the diet had no effect on milk yield but significantly decreased milk fat concentration with both forages.
Nucleoplasmic LAP2α–lamin A complexes are required to maintain a proliferative state in human fibroblasts

In human diploid fibroblasts (HDFs), expression of lamina-associated polypeptide 2 α (LAP2α) upon entry and exit from G0 is tightly correlated with phosphorylation and subnuclear localization of retinoblastoma protein (Rb). Phosphoisoforms of Rb and LAP2α are down-regulated in G0. Although RbS780 phosphoform and LAP2α are up-regulated upon reentry into G1 and colocalize in the nucleoplasm, RbS795 migrates between nucleoplasmic and speckle compartments. In HDFs, which are null for lamins A/C, LAP2α is mislocalized within nuclear aggregates, and this is correlated with cell cycle arrest and accumulation of Rb within speckles. Nuclear retention of nucleoplasmic Rb during G1 phase but not of speckle-associated Rb depends on lamin A/C. siRNA knock down of LAP2α or lamin A/C in HDFs leads to accumulation of Rb in speckles and G1 arrest, probably because of activation of a cell cycle checkpoint. Our results suggest that LAP2α and lamin A/C are involved in controlling Rb localization and phosphorylation, and a lack or mislocalization of either protein leads to cell cycle arrest in HDFs.
Genetic risk for white matter abnormalities in bipolar disorder

White matter deficits have been demonstrated in people with bipolar disorder, schizophrenia and their unaffected relatives. These deficits are supported by evidence from post-mortem studies, including microarray investigations which have repeatedly implicated abnormal myelin-associated gene expression. Furthermore, several risk-associated genes have now been identified that encode for proteins which have effects on white matter integrity. These genes include neuregulin-1 (NRG1) polymorphisms of which have been associated with risk to bipolar disorder. NRG1 has been shown to have effects on axonal migration, myelination and oligodendrocyte function. We and others have also shown that 5′ risk-associated genetic variants in NRG1 are associated with reductions in both white matter density and integrity in regions associated with prefrontal connectivity. These findings are discussed in the context of the current literature, along with possible future research directions.
Real user-environment migration between heterogeneous ISA platforms

Virtualization technology has recently been widely used due to its various benefits, such as reducing system management efforts and increasing system utilization. Each execution environment can be isolated from other environments as each user can have access to virtual resources provided by the virtualization layer. This achieves benefits such as increasing reliability and security, and increases system mobility because applications and operating systems running on a virtual machine can migrate to other systems using the same virtualization layer. Virtualization technology is being extended to embedded systems, such as mobile phones, as well as to traditional IT systems, such as servers and PCs. Such extended virtualization technology to this domain requires migrating virtual machines between heterogeneous platforms, such as PCs, TVs, and mobile phones, beyond the existing virtual machine migration between homogeneous platforms. Virtual machine migration between heterogeneous platforms has additional benefits, such as increasing computing power of the execution environment, increasing device expandability, and achieving real migration of the user environment. In this paper, we present the real user- environment migration between heterogeneous platforms and design the architecture. We execute and evaluate virtual machine migration between the x86 platforms and the SPARC platform using our modified QEMU to verify the concept. Users can experience real user-environment migration between heterogeneous platforms using this method.
Source-Adaptation-Based Wireless Video Transport: A Cross-Layer Approach

Real-time packet video transmission over wireless networks is expected to experience bursty packet losses that can cause substantial degradation to the transmitted video quality. In wireless networks, channel state information is hard to obtain in a reliable and timely manner due to the rapid change of wireless environments. However, the source motion information is always available and can be obtained easily and accurately from video sequences. Therefore, in this paper, we propose a novel cross-layer framework that exploits only the motion information inherent in video sequences and efficiently combines a packetization scheme, a cross-layer forward error correction (FEC)-based unequal error protection (UEP) scheme, an intracoding rate selection scheme as well as a novel intraframe interleaving scheme. Our objective and subjective results demonstrate that the proposed approach is very effective in dealing with the bursty packet losses occurring on wireless networks without incurring any additional implementation complexity or delay. Thus, the simplicity of our proposed system has important implications for the implementation of a practical real-time video transmission system.
Distributed Architecture of an Autonomous Four Rotor Mini-Rotorcraft based on Multi-Agent System

— In this paper, we present the recently implemented approach allowing dynamics systems to plan its actions, taking into account the environment perception changes, and to control their execution when uncertainty and incomplete knowledge are the major characteristics of the situated environment [1],[2],[3],[4]. The control distributed architecture has three modules and the approach is related to hierarchical planning: the plan produced by the planner is further refined at the control layer that in turn supervises its execution by a functional level. We propose a new intelligent distributed architecture constituted by: Multi-Agent subsystem of the sensor, of the interpretation and representation of environment [9], of the dynamic localization and of the action. We tested this distributed architecture with dynamic system in the known environment. The autonomous for Rotor Mini Rotorcraft task is described by the primitive actions. The distributed controlbased on multi-agent system is in charge of achieving each task in the best possible way taking into account the context and sensory feedback.
Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family inC

In animals, microRNAs frequently form families with related sequences. The functional relevance of miRNA families and the relative contribution of family members to target repression have remained, however, largely unexplored. Here, we used the Caenorhabditis elegans miR-58 miRNA family, composed primarily of the four highly abundant members miR-58.1, miR-80, miR-81, and miR-82, as a model to investigate the redundancy of miRNA family members and their impact on target expression in an in vivo setting. We found that miR-58 family members repress largely overlapping sets of targets in a predominantly additive fashion. Progressive deletions of miR-58 family members lead to cumulative up-regulation of target protein and RNA levels. Phenotypic defects could only be observed in the family quadruple mutant, which also showed the strongest change in target protein levels. Interestingly, although the seed sequences of miR-80 and miR-58.1 differ in a single nucleotide, predicted canonical miR-80 targets were efficiently up-regulated in the mir-58.1 single mutant, indicating functional redundancy of distinct members of this miRNA family. At the aggregate level, target binding leads mainly to mRNA degradation, although we also observed some degree of translational inhibition, particularly in the single miR-58 family mutants. These results provide a framework for understanding how miRNA family members interact to regulate target mRNAs. DOI: https://doi.org/10.1101/gr.183160. 114 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-116121 Accepted Version Originally published at: Subasic, Deni; Brümmer, Anneke; Wu, Yibo; Pinto, Sérgio Morgado; Imig, Jochen; Keller, Martin; Jovanovic, Marko; Lightfoot, Helen Louise; Nasso, Sara; Goetze, Sandra; Brunner, Erich; Hall, Jonathan; Aebersold, Ruedi; Zavolan, Mihaela; Hengartner, Michael O (2015). Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family inC. elegans. Genome Research, 25(11):1680-1691. DOI: https://doi.org/10.1101/gr.183160. 114
The Clinico-pathological Syndrome Produced by Co-existing Pulmonary Arterial and Venous Hypertension

In the last decade cardiac catheterization has demonstrated that the pressure in the pulmonary arteries and veins may greatly influence the clinical picture and prognosis in various forms of heart disease. Cases with severe pulmonary arterial hypertension show the clinico-pathological syndrome of hypertensive pulmonary vascular disease (Heath and Whitaker, 1956a). Severe pulmonary venous hypertension, following left ventricular failure due to diffuse myocardial disease, is associated with a clinical picture similar to that of constrictive pericarditis and the pathological features of pulmonary congestion and haemosiderosis. The purpose of this communication is to report the association of pulmonary arterial and venous hypertension in a case of diffuse myocardial fibrosis, a state of affairs which represents the fusion of the two main clinico-pathological pressure syndromes. The histology of the lung and the results of cardiac catheterization are described. These findings are compared and contrasted with similar observations from previously reported cases of each of the pressure syndromes. The role of a raised pressure in the pulmonary veins in the aetiology of pulmonary arterial hypertension is discussed.
Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid

The mechanisms driving pathological beta‐amyloid (Aβ) generation in late‐onset Alzheimer's disease (AD) are unclear. Two late‐onset AD risk factors, Bin1 and CD2AP, are regulators of endocytic trafficking, but it is unclear how their endocytic function regulates Aβ generation in neurons. We identify a novel neuron‐specific polarisation of Aβ generation controlled by Bin1 and CD2AP. We discover that Bin1 and CD2AP control Aβ generation in axonal and dendritic early endosomes, respectively. Both Bin1 loss of function and CD2AP loss of function raise Aβ generation by increasing APP and BACE1 convergence in early endosomes, however via distinct sorting events. When Bin1 levels are reduced, BACE1 is trapped in tubules of early endosomes and fails to recycle in axons. When CD2AP levels are reduced, APP is trapped at the limiting membrane of early endosomes and fails to be sorted for degradation in dendrites. Hence, Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Aβ in neurons increasing the risk for late‐onset AD.
Functional and Clinical Significance of Variants Localized to 8q24 in Colon Cancer

Multiple genome-wide association studies have identified several susceptibility variants for colon cancer at 8q24. However, the functional roles of these variants have yet to be elucidated. Here, we evaluated the potential role of these markers in tumor progression and examined association with commonly observed structural abnormalities in this region, c-MYC amplification and chromosome fragility at FRA8C and FRA8D. We first replicated the previously reported association by testing 1,178 cases and 1,009 clinic-based controls with eight markers localized to three specific regions at 8q24. We observed significant associations with colon cancer risk with markers rs13254738 (ordinal odds ratio, 0.82; 95% confidence interval, 0.072-0.94; Ptrend = 0.0037) and rs6983267 (ordinal odds ratio, 1.17; 95% confidence interval, 1.03-1.32, Ptrend = 0.013). Survival analysis was done using a separate set of 460 cases to evaluate the clinical significance of these markers. Overall, univariate analysis did not detect survival differences for any of the markers. We also tested a subset of the 460 cases (n = 380) for structural abnormalities at or near the c-MYC locus using fluorescence in situ hybridization analysis. Furthermore, we evaluated a small number of cases homozygous for the rs6983267 alleles to test for differences in fragile site induction. None of the 8q markers correlated with amplification at the c-MYC locus as detected by fluorescence in situ hybridization, and no clear pattern of breakage was observed at the FRA8C and FRA8D sites. In this study, we confirm the association for several single nucleotide polymorphisms at 8q24 in colon cancer but have not detected any structural role relating to c-MYC amplification or chromosomal fragility. Finally, these risk alleles do not seem to be associated with survival. (Cancer Epidemiol Biomarkers Prev 2009;18(9):2492–500)
Antitubercular effect of 8-[(4-Chloro phenyl) sulfonyl]-7-Hydroxy-4-Methyl-2H-chromen-2-One in guinea pigs

Objective: To evaluate the antitubercular efficacy and safety of New Chemical Entity (NCE): 8-[(4-Chloro phenyl) sulfonyl]-7-Hydroxy-4-Methyl-2H-chromen-2-One (CSHMC) in guinea pigs. Materials and Methods: This pilot study was carried out in guinea pigs. They were infected with M. tuberculosis H37Rv (1.5 × 104 cfu/guinea pig) via intramuscular route. After 30 days, infections were confirmed in 6 guinea pigs by histopathology of spleen, lung, and liver. After that CSHMC (5 and 20 mg/kg) was administered for 1 month and its effect was compared with vehicle, rifampicin (60 mg/kg) and isoniazid (30 mg/kg). Efficacy of CSHMC was evaluated on the basis of histopathologic scoring of lesion in lung, spleen, liver, and safety on the basis of measuring hemogram, liver and renal function parameters. Results: Isoniazid, rifampicin, and CSHMC (20 mg/kg) significantly reduce the median lesion score in lung, spleen, and liver as compared to disease control group. Reduction in median lesion score for lung and spleen were not statistically significant for CSHMC 5 mg/kg. CSHMC (20 and 5 mg/kg) did not produce any changes in hemogram, liver and renal function parameters with respect to normal values. Conclusions: CSHMC had shown significant antitubercular efficacy comparable to isoniazid and rifampicin and did not show hematological, hepato- and nephrotoxicity.
Compensatory carotid artery dilatation in early atherosclerosis.

BACKGROUND From pathological studies of coronary arteries, it has been recognized that progressive plaque development may be compensated for by an increase of the arterial diameter. However, the dynamics of this process have not been investigated, and it is not known whether compensatory dilatation is a general pathomechanism in human arteries. METHODS AND RESULTS Using a high-resolution duplex scanner and subsequent three-dimensional plaque reconstruction, we prospectively studied the effect of carotid plaque development on the vascular geometry in 32 patients at 6- to 12-month intervals. Plaque progression in 41% (n = 26) of studies was associated with an increase of the vessel diameter between 0.4 and 1.2 mm in 76% (n = 20). Among 36 unchanged plaque developments, enlargement of the arterial diameter was assessed in only 28% (n = 10) (P < .001). CONCLUSIONS Our data suggest that increasing plaque volume is significantly associated with enlargement of carotid artery segments, which compensates for arterial narrowing in early stages of the disease.
Decentralized Dynamic Participation in Participatory Sensing: A Correlated-Equilibrium Game Approach

Participatory sensing has become a compelling and viable paradigm for large scale sensing data collection in recent years, with smartphone workers recruited from a public crowd. Since the quality of the sensing data is directly related to the performance of the workers, it is then crucial to enable effective participation for a large number of workers. In this paper, we propose a decentralized dynamic participation game framework for participatory sensing systems with heterogeneous sensing processes and smartphone workers. Based on economic studies, we characterize the behaviour of workers with the idea of correlated equilibrium. We propose a regret matching based participation algorithm to track the set of correlated equilibria in a distributed manner, where the knowledge of competitors' preference information is not required. Simulation results demonstrate that our algorithm achieves good convergence and effective participation.
The six‐minute walk test: a useful metric for the cardiopulmonary patient

Measurement of exercise capacity is an integral element in assessment of patients with cardiopulmonary disease. The 6‐min walk test (6MWT) provides information regarding functional capacity, response to therapy and prognosis across a range of chronic cardiopulmonary conditions. A distance less than 350 m is associated with increased mortality in chronic obstructive pulmonary disease, chronic heart failure and pulmonary arterial hypertension. Desaturation during a 6MWT is an important prognostic indicator for patients with interstitial lung disease. The 6MWT is sensitive to commonly used therapies in chronic obstructive pulmonary disease such as pulmonary rehabilitation, oxygen, long‐term use of inhaled corticosteroids and lung volume reduction surgery. However, it appears less reliable to detect changes in clinical status associated with medical therapies for heart failure. A change in walking distance of more than 50 m is clinically significant in most disease states. When interpreting the results of a 6MWT, consideration should be given to choice of predictive values and the methods by which the test was carried out.
Broadband Mobile Ad hoc Network System for Emergency Communications

This paper describes broadband mobile Ad hoc network system for emergency (or disaster) communications. The disaster communication network is based on mobile ad hoc network and the traffic will be increased and concentrated on specific site. For communication services under disaster circumstance, this paper considers mobility, variable packet length to reduce transmission overheads, dynamic routing protocol to provide efficient data transmission path and application-level support to provide realtime multimedia services. This paper adopts two-way satellite communication systems (forward link for DVB-S2, return link for DVB-RCS) for disaster communications. With these considerations, a disaster communication system can provide PPDR services efficiently in mobile ad hoc network environments.
ExPort: Detecting and visualizing API usages in large source code repositories

This paper presents a technique for automatically mining and visualizing API usage examples. In contrast to previous approaches, our technique is capable of finding examples of API usage that occur across several functions in a program. This distinction is important because of a gap between what current API learning tools provide and what programmers need: current tools extract relatively small examples from single files/functions, even though programmers use APIs to build large software. The small examples are helpful in the initial stages of API learning, but leave out details that are helpful in later stages. Our technique is intended to fill this gap. It works by representing software as a Relational Topic Model, where API calls and the functions that use them are modeled as a document network. Given a starting API, our approach can recommend complex API usage examples mined from a repository of over 14 million Java methods.