Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Application of an Ecodriving Support Platform Based on Internet+: Case Study in Beijing Taxicabs

This research developed an ecodriving support platform based on Internet+ technology and aimed at real-time dynamic collection and feedback optimization of driving behavior. The system served government and enterprises in monitoring and managing drivers’ driving behaviors and provides practical ecodriving feedback information on improvement in individual drivers’ driving behavior through a smartphone app. The vehicle operation data were collected by onboard diagnostics and GPS devices mounted on vehicles, and then these basic data were transmitted to the cloud platform for storage through a 3G network. The user information about ecodriving behaviors was created and stored in a local server. Nine driving events related to ecodriving and an ecodriving score could be detected and estimated. The validation test of 50 taxicab drivers’ fuel consumption of 1 month before and after receiving ecodriving feedback through the smartphone app showed that the effectiveness of the ecodriving app on reducing fuel consumption was statistically significant, with an average reduction of 4.5% and the highest of 13.0%. Furthermore, both the adaptive process at the beginning of and a long-term effect after a period of time were maintained for ecodriving training through the smartphone app. In addition, the relationship between vehicle fuel consumption and app usage frequency was found to be highly linear: fuel consumption decreased as app usage increased. The study results demonstrated a real-time dynamic and practical approach for the ecodriving app and further provided a research platform for monitoring and management of driving behavior in the big data era.
Cubitt, Robin P. and Sugden, Robert (2014) Common reasoning in games: a Lewisian analysis of common

We present a new class of models of players’ reasoning in non-cooperative games, inspired by David Lewis’s account of common knowledge. We argue that the models in this class formalise common knowledge of rationality in a way that is distinctive, in virtue of modelling steps of reasoning; and attractive, in virtue of being able to represent coherently common knowledge of any consistent standard of individual decision-theoretic rationality. We contrast our approach with that of Robert Aumann (1987), arguing that the former avoids and diagnoses certain paradoxes to which the latter may give rise when extended in particular ways.
F ISCAL P OLICY AND M ACRO ECONOMIC S TABILISATION IN THE E URO A REA : P OSSIBLE R EFORMS OF THE S TABILITY AND G ROWTH P ACT AND N

The recent economic-policy debate in the EU has largely focused on fiscal policy and the Stability and Growth Pact. The reason is the current budgetary problems of some member states. Portugal breached the three-percent-of-GDP deficit ceiling in 2001 and 2002. Germany breached it in 2002, and may also do so in 2003. France and Italy have abandoned their commitments to earlier agreed budget objectives and there is a clear threat that they may violate the deficit ceiling, too. These events have contributed to a revival of the debate on the fiscal policy framework in the EU. The European Commission has recently proposed a number of changes in the Stability and Growth Pact (European Commission, 2002b). There have also been calls for more fundamental revisions of the EU fiscal policy framework including proposals to scrap the Stability and Growth Pact altogether (see, for example, Financial Times, 2002a,b,c; Economist, 2002; de Grauwe, 2002; or Walton, 2002).
Identi¢cationoftheMesorhizobium loti gene responsible for glycerophosphorylationof periplasmic cyclic b-1,2-glucans

Periplasmic cyclic b-1,2-glucans play a crucial role in symbiosis as well as in hypoosmotic adaptation for rhizobia. These glucans are modified in many species by anionic substituents such as glycerophosphoryl and succinyl ones, but their role remains to be examined. In this work, the cgmA homolog is shown to be responsible for glycerophosphorylation of cyclic b-1,2-glucans in Mesorhizobium loti. The mutation in cgmA converted most anionic glucans into neutral ones, leaving a small amount of succinylated ones. An additional mutation in opgC, which encodes a succinyltransferase homolog, abolished the residual succinyl substituents in the cgmA-mutant background. The double mutant in cgmA and opgC did not show any significant phenotypic differences from the wild type during both vegetative growth and symbiosis. It is concluded that the anionic substituents make a minor contribution, if any, to the effectiveness of cyclic b-1,2glucans in M. loti.
CMAR_A_269388 9941..9952

*These authors contributed equally to this work Purpose: KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GISTs) represent a heterogeneous subgroup of GISTs that lack KIT or PDGFRA mutations and possess distinct genetic alterations and primary resistance to imatinib. Succinate dehydrogenase (SDH)deficient GISTs comprise the largest subpopulation of WT GISTs that are characterized by loss-of-function of SDH. O6-methylguanine-DNA methyltransferase (MGMT) is a specific DNA repair enzyme that has been identified as a predictor of positive treatment response to alkylating agents in a variety of cancers. The aim of this study was to evaluate the expression of MGMT and the prevalence of MGMT promoter methylation in GISTs and to determine the association between MGMT promoter methylation and clinicopathological characteristics and clinical outcomes. Patients and Methods: A heterogeneous cohort of 137 primary GISTs that confirmed by immunohistochemistry and KIT/PDGFRA mutation analysis were retrospectively selected and analyzed for MGMT expression and MGMT promoter methylation using immunohistochemical staining and methylation-specific PCR (MSP). A concordance analysis between MGMT promoter methylation and clinicopathological characteristics and prognosis was also performed. Results: A total of 44.5% (65/137) of GIST patients displayed loss of MGMT protein expression, and 10.9% (15/137) of these patients exhibited MGMT promoter methylation. However, no significant correlation was observed between the loss of MGMT protein expression and MGMT promoter methylation. WT GISTs possessing an epithelioid or mixed phenotype, particularly those that were SDH-deficient, displayed a markedly higher prevalence of MGMT promoter methylation compared to that in KIT/PDGFRA mutated GISTs. Moreover, MGMT promoter methylation was identified as a potential independent prognostic factor for OS and DFS in patients with GIST. Conclusion: MGMT promoter methylation is particularly frequent in SDH-deficient GISTs and in WT GISTs possessing an epithelioid/mixed phenotype, and knowledge of this methylation status may offer a novel potential therapeutic option for WT GISTs.
Morris, Carol and Helliwell, Richard and Raman, Sujatha (2016) Framing the agricultural use of antibiotics and antimicrobial resistance in UK national newspapers and the farming

Despite links to animal disease governance, food and biosecurity, rural studies has neglected consideration of how actors make sense of the use of antibiotics in animal agriculture and the implications for animal and human health. As antimicrobial resistance (AMR) has become a highprofile problem, the contribution of animal antibiotics is frequently mentioned in scientific and policy documents but how different agricultural actors interpret its significance is less clear. This paper offers the first social scientific investigation of contestation and consensus surrounding the use of antibiotics in agriculture and their implications for AMR as mediated through mainstream news-media and farming print media in the UK. Frame analysis of four national newspapers and one farming paper reveals three distinct frames. A ‘system failure’ frame is the most frequently occurring and positions intensive livestock production systems as a key contributor to AMR-related crises in human health. A ‘maintaining the status quo’ frame argues that there is no evidence linking antibiotics in farming to AMR in humans and stresses the necessity of (some) antibiotic use for animal health. A third frame which is only present in the farming media – highlights a need for voluntary, industryled action on animal antibiotic use in terms of farmer self-interest. Common to all frames is that the relationship between agricultural use of antibiotics and problems posed by AMR is mostly discussed in terms of the implications for human health as opposed to both human and animal health.
Investigation of Heavy Metal Hyperaccumulation at the Cellular Level: Development and Characterization of Thlaspi caerulescens Suspension Cell Lines 1[OA]

The ability of Thlaspi caerulescens , a zinc (Zn)/cadmium (Cd) hyperaccumulator, to accumulate extremely high foliar concen- trations of toxic heavy metals requires coordination of uptake, transport, and sequestration to avoid damage to the photosynthetic machinery. The study of these metal hyperaccumulation processes at the cellular level in T. caerulescens has been hampered by the lack of a cellular system that mimics the whole plant, is easily transformable, and competent for longer term studies. Therefore, to better understand the contribution of the cellular physiology and molecular biology to Zn/Cd hyperaccumulation in the intact plant, T. caerulescens suspension cell lines were developed. Differences in cellular metal tolerance and accumulation between the cell lines of T. caerulescens and the related nonhyperaccumulator, Arabidopsis ( Arabidopsis thaliana ), were examined. A number of Zn/Cd transport-related differences between T. caerulescens and Arabidopsis cell lines were identiﬁed that also are seen in the whole plant. T. caerulescens suspension cell lines exhibited: (1) higher growth requirements for Zn; (2) much greater Zn and Cd tolerance; (3) enhanced expression of speciﬁc metal transport-related genes; and (4) signiﬁcant differences in metal ﬂuxes compared with Arabidopsis. One interesting feature exhibited by the T. caerulescens cell lines was that they accumulated less Zn and Cd than the Arabidopsis cell lines, most likely due to a greater metal efﬂux. This ﬁnding suggests that the T. caerulescens suspension cells represent cells of the Zn/Cd transport pathway between the root epidermis and leaf. We also show it is possible to stably transform T. caerulescens suspension cells, which will allow us to alter the expression us homologous regions within the genes of interest for both T. caerulescens (Prayon) and Arabidopsis (L er ), and PCR products ranged in length from 300 to 1,000 bp. The primers were designed from the following National Center for Biotechnology Information identiﬁed sequences: HMA4 (Tc:AY486001; At:AJ297264), MTP1 (Tc:AY483146; At:NM_180128), and ZNT1 (Tc:AF133267; At:NM_100972). The Arabidopsis housekeeping gene ACT2 (NM_112764) and its closest T. caerulescens ortholog were used as controls. Initial control reactions showed that under the chosen conditions, all PCR products were in the linear ampliﬁcation range (data not shown). The experiments were repeated using three biological replicates, and duplicate RT-PCR experiments were conducted for each gene from each biological replicate.
Diffuse Interface Model of Microstructure Formation in Solidification with Anisotropy based on Finsler Geometry

In the article, we analyse the anisotropic phase-field model of microstructure growth in solidification of pure crystallic materials. The anisotropy has been previously introduced into the model using the concept of Finsler geometry which allows to define the notion of weak solution and to show the existence and uniqueness. For this purpose, we obtain two a priori estimates, and use the compactness method. Furthermore, we investigate the asymptotic behaviour of the solution when the diffuse-layer thickness tends to zero.
Bacterial symbionts in the hepatopancreasof isopods: diversityand environmental transmission

The midgut glands (hepatopancreas) of terrestrial isopods contain bacterial symbionts. We analysed the phylogenetic diversity of hepatopancreatic bacteria in isopod species from various suborders colonizing marine, semiterrestrial, terrestrial and freshwater habitats. Hepatopancreatic bacteria were absent in the marine isopod Idotea balthica (Valvifera). The symbiotic bacteria present in the midgut glands of the freshwater isopod Asellus aquaticus (Asellota) were closely related to members of the proteobacterial genera Rhodobacter, Burkholderia, Aeromonas or Rickettsiella, but differed markedly between populations. By contrast, species of the suborder Oniscidea were consistently colonized by the same phylotypes of hepatopancreatic bacteria. While symbionts in the semiterrestrial isopod Ligia oceanica (Oniscidea) were close relatives of Pseudomonas sp. (Gammaproteobacteria), individuals of the terrestrial isopod Oniscus asellus (Oniscidea) harboured either ‘Candidatus Hepatoplasma crinochetorum’ (Mollicutes) or ‘Candidatus Hepatincola porcellionum’ (Rickettsiales), previously described as symbionts of another terrestrial isopod, Porcellio scaber. These two uncultivated bacterial taxa were consistently present in each population of six and three different species of terrestrial isopods, respectively, collected in different geographical locations. However, infection rates of individuals within a population ranged between 10% and 100%, rendering vertical transmission unlikely. Rather, feeding experiments suggest that ‘Candidatus Hepatoplasma crinochetorum’ is environmentally transmitted to the progeny.
Losartan reduces the increased participation of COX-2 derived products in vascular responses of hypertensive rats

This study analyzes the role of angiotensin II (Ang II), via AT1 receptors, in the involvement of cyclooxygenase-2 (COX-2)-derived prostanoids in phenylephrine responses in normotensive (WKY) and spontaneously hypertensive (SHR) rats. Aorta from rats untreated or treated for 12 weeks with losartan (15 mg/kg·day) or hydralazine plus hydrochlorothiazide (44 and 9.4 mg/kg·day, respectively) and vascular smooth muscle cells (VSMC) from SHR were used. Vascular reactivity was analyzed by isometric recording, COX-2 expression by Western blot and RT-PCR, PGI2, PGF2α, 8-isoprostane and total antioxidant status (TAS) by commercial kits, superoxide anion (O2 ) using lucigenin chemiluminiscence and plasmatic malondialdehyde (MDA) by thiobarbituric acid assay. The COX-2 inhibitor NS 398 (1 μM) reduced phenylephrine responses more in SHR than in WKY. COX-2 protein and mRNA expressions, PGF2α, PGI2, 8-isoprostane and O2 production and MDA levels were higher in SHR but TAS was similar in both strains. Losartan, but not hydralazine-hydrochlorothiazide treatment, reduced COX-2 expression and the effect of NS 398 in SHR. Losartan also increased TAS and reduced PGF2α, PGI2, 8-isoprostane and O2 -. production and MDA levels in SHR. Ang II (0.1 μM) induced COX-2 expression in VSMC from SHR, that was reduced by apocynin (30 μM) and allopurinol (100 μM), NADPH oxidase and xanthine oxidase inhibitors, respectively. In conclusion, AT1 receptor activation by Ang II could be involved in the increased participation of COX-2-derived contractile prostanoids in vasoconstriction to phenylephrine with hypertension, probably through COX-2 expression regulation. The increased oxidative stress seems to be one of the mechanisms involved. This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on January 23, 2007 as DOI: 10.1124/jpet.106. 115287 at A PE T Jornals on A uust 5, 2017 jpet.asjournals. org D ow nladed from
THE IMPACT OF GOVERNMENT SIZE ON REGIONAL ECONOMIC GROWTH IN INDONESIA : TESTING THE NON-MONOTONIC RELATIONSHIP

Previous studies have illustrated a non-monotonic relationship between government size and economic growth. In this non-monotonic relationship, the increase in government size is beneficial until a certain threshold. However, above that threshold, it has a deleterious effect on economic growth. Using panel data from 30 provinces in Indonesia for the 2001–2015 period, this study applies a threshold analysis to investigate the non-monotonic relationship between government size and regional economic growth. After the estimated threshold has been identified and proven to be statistically significant, the estimated threshold is interacted with government size. The effect of government size, below and above the threshold, is then estimated by the fixed effects estimation and the generalized method of moments (GMM) estimation using Arellano and Bond’s (1991) instrument type. The GMM is applied to account for the possibility of reverse causality and endogeneity. Both estimation methods can weakly support the non-monotonic hypothesis in the relationship between government size and regional economic growth, which illustrates changes in the slope of the coefficient around the threshold value. Graduate Program in Economics, Faculty of Economics and Business, Universitas Indonesia INTRODUCTION The role of government size on the growth of an economy is an important economic topic of debate. Different arguments have arisen on the discussion of the role of government size on economic growth. Some studies argue that government size has a positive impact on economic growth. More specifically, Rubinson (1977) and Ram (1986) argued that government size plays an influential role in stimulating economic growth, because the government administers public goods and services and raises the capacity of private sector inputs that will increase total output. Other studies argue that government size depresses economic growth, due to government inefficiencies or unproductive economic activities (Landau, 1983; Peden and Bradley, 1989). In the meanwhile, some researchers argue that government size has a positive impact on growth when the share of government economic activity is small, but an adverse effect when the relative size of the government increases. The initial positive impact occurs because the government provides essential public goods that contribute to
Diabetes Incidence in the MEC Diabetes Incidence Based on Linkages with Health Plans: The Multiethnic Cohort Running title: Diabetes Incidence in the MEC

Gertraud Maskarinec, MD, PhD Eva Erber, MS Andrew Grandinetti, PhD Martijn Verheus, PhD Robert Oum, MS Beth Hopping Mark M. Schmidt, BA Aileen Uchida, MPH Deborah Taira Juarez, ScD 4 Krista Hodges, MBA, MPH Laurence N. Kolonel, MD, PhD Cancer Research Center, University of Hawaii, Honolulu, HI John A. Burns School of Medicine, University of Hawaii, Honolulu, HI Kaiser Permanente Center for Health Research, Honolulu, HI HMSA, Blue Cross Blue Shield of Hawaii
Triboelectricity and construction of power generators based on it

The topic of using tribolectrics as a promising source of energy has been actualized in this article. The data on the main types of generators in triboelectricity have been analyzed. The schematic solutions for the application of tribogenerators in various devices based on electronic modules of various manufacturers have been presented. The conclusion about the high efficiency of the use of tribogenerators in applied devices, when combined with other energy sources and accumulating it with super capacitors has been made. Streszczenie: Artykuł dotyczy tematu wykorzystania efektu tryboelektrycznego jako obiecującego żródła energii. Przeanalizowano techniczne parametry głównych typów generatorów w tryboelektrown. Przedstawione schemotechniczne rozwiązania w zakresie zastosowania trybogeneratorów. Wykazano dużą efektywnośći połączenia trybogeneratorów z innymi Źródłami energii i superkondensatorami dla akumulowania energii. Efekt tryboelektryczny i generator, zbudowany na jego podstawie
University of Birmingham Attentional bias to threat-related information among individuals with dental complaints

Expecting pain can be perceived as a threat may involve recruitment of cognitive strategies (such as attentional avoidance) which might help the person to reduce distress. The ecological validity of the paradigms aiming to study the attentional biases toward or away from threatening stimuli by manipulating the perception of threat in experimental settings has been questioned. Therefore, the current study aims to investigate the attentional bias toward or away from the threat when a confrontation with a real threatening and painful condition would be expected (i.e., dental treatment). One hundred and twenty-seven patients referred to three dentistry clinics for a dental treatment (experiment participants) and 30 individuals with no dental complaints (control participants) completed this study. Patients were randomly allocated to a high pain expectancy (HPE: n = 65) or a low pain expectancy (LPE: n = 62) expectancy condition. All participants completed questionnaires of distress, fear of pain, and fear of dental pain. Furthermore, they participated in a dot-probe task that assessed their attention to painful faces, dental pictures, and happy faces. In addition, before the treatment, participants reported their anticipated pain intensity and after the treatment, they reported the pain intensity that they perceived during the treatment using two separate visual analog scales. Patients in the HPE group showed a bias away from dental pictures compared to LPE and control group participants. HPE group patients also reported greater pain intensity during the treatment compared to LPE patients. Greater attentional bias away from dental pictures among HPE patients was associated with higher levels of fear of pain, fear of dental pain, and stress. Avoidance of highly salient threatening images can be seen as an unhelpful emotion-regulation strategy that individuals use to manage their fears. However, in this study, avoidance was associated with poorer outcomes.
Nephrology Dialysis Transplantation Correlation between glomerular morphology and renal haemodynamic response to amino-acid administration in patients with IgA nephropathy

Rationale. To establish relationship, if any, between renal morphology and renal haemodynamic response to amino acids. Design and methods. We investigated the correlation between renal haemodynamic regulation and morphology in a group of 15 patients with primary IgA nephropathy (IgAN) (age 26 + 2 years, BMI 24.4 + 1, GFR 64+ 5 ml/min, RPF 377 + 34 ml/min, FF 0.17 + 0.02). Twelve normal subjects (age 30 + 3 years, BMI 24± 1, GFR 82 + 6 ml/min, RPF421 +42 ml/min, FF 0.19 + 0.02) were studied as controls. IgA patients were divided into two groups according to the histological staging of glomerular lesions: group I (« = 7) stage II, and group II (« = 8) stage III—IV. Results. In the basal state GFR was similar in the two groups and averaged 64 + 9 and 64 + 6 ml/min respectively. In contrast, FF was significantly lower in group II (0.14 ±0.01) (P<0.05) in comparison to group I (0.21+0.03) and controls (0.19 + 0.02). In order to evaluate the renal functional reserve, all study groups underwent to an intravenous amino-acid infusion designed to increase plasma amino acid levels twofold (total from 2096 + 145 to 4301 +221 umol/1 in IgA nephropathy patients and from 2272 + 83 to 3844 + 238 umol/1 in controls). In response to aminoacid infusion, GFR rose significantly in group I (GFR 20±2% and RPF 37+4% versus basal) and controls (GFR 20 + 2% and RPF 20 + 3% versus basal) (both P<0.0l vs basal). In contrast, in patients with more severe glomerular lesions (group II) neither GFR nor RPF rose significantly (GFR 1 + 4 % and RPF 8 ± 6 % versus basal) (P NS versus basal, P<0.0l versus group I and controls). Conclusions. The data show that in IgA nephropathy: severe forms of glomerular lesions are associated with a complex alteration of glomerular haemodynamic regulation, characterized by lower basal FF and loss of haemodynamic response to hyperaminoacidaemia. Correspondence and offprint requests to: Pietro Castellino MD, Via R. De Cesare 31, 80131 Napoli, Italy.