Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of DUSP6 Activates Autophagy and Rescues the Retinal Pigment Epithelium in Sodium Iodate-Induced Retinal Degeneration Models In Vivo and In Vitro

Autophagy plays a protective role in the retinal pigment epithelium (RPE) by eliminating damaged organelles in response to reactive oxygen species (ROS). Dual-specificity protein phosphatase 6 (DUSP6), which belongs to the DUSP subfamily, works as a negative-feedback regulator of the extracellular signal-regulated kinase (ERK) pathway. However, the complex interplay between DUSP6 and autophagy induced by ROS in RPE is yet to be investigated. To investigate the relationship between DUSP6 and autophagy, we exposed the ARPE-19 cell line and C57BL/6N mice to sodium iodate (NaIO3) as an oxidative stress inducer. Our data showed that the inhibition of DUSP6 activity promotes autophagy flux through the ERK pathway via the upregulation of immunoblotting expression in ARPE-19 cells. Live imaging showed a significant increase in autophagic flux activities, which suggested the restoration autophagy after treatment with the DUSP6 inhibitor. Furthermore, the mouse RPE layer exhibited an irregular structure and abnormal deposits following NaIO3 injection. The retina layer was recovered after being treated with DUSP6 inhibitor; this suggests that DUSP6 inhibitor can rescue retinal damage by restoring the mouse retina’s autophagy flux. This study suggests that the upregulation of DUSP6 can cause autophagy flux malfunctions in the RPE. The DUSP6 inhibitor can restore autophagy induction, which may serve as a potential therapeutic approach for retinal degeneration disease.
Reinventing Luxury Travel Imaginaries: Early Responses of Travel Influencers to the COVID-19 Pandemic

This chapter assesses how luxury travel imaginaries were modified in the aftermath of the outbreak of the coronavirus pandemic. Drawing on long-term fieldwork among travel influencers, the chapter presents their response strategies to the COVID-19 pandemic. Based on an analysis of evidence from participant observation in tourist sites, network visualisations, in-depth interviews and platform profiles, I trace the transformations luxury travel imaginaries have undergone since the beginning of 2020. Before this global crisis, travel influencers became new puissant players in the highly globalised tourism industry as they regularly received assignments from tourism boards and hotels. Although brand sponsorship was considered a substantial source of revenue for travel influencers, their collaborations in travel destinations and the monetisation of travel content on YouTube were further assets to secure a livelihood. The coronavirus outbreak, however, turned their life-worlds upside down. This ethnographic investigation identified three main responses of travel influencers to the current long-term crisis of tourism: (1) diversification of content creation and orientation towards other influencer genres, (2) support for local tourism organisations and online promotion of staycations and (3), finally, travel to tourist sites for circulating online content on safe travel standards. Digital platforms became a major arena where the future of tourism has been re-negotiated in the wake of the COVID-19 outbreak. The in-depth investigation suggests that travel influencers were in a position to create new powerful representations of luxury as safe travel since they acquired the skills to establish stable storyworlds for their travel experiences, which attracted the attention of large platform audiences. © 2022 by Emerald Publishing Limited. All rights reserved.
A Scoring Procedure for Malignant Narcissism Based on Personality Inventory for DSM-5 Facets

Abstract The current study focuses on the development and validation of a scoring procedure for malignant narcissism using the Personality Inventory for DSM-5, a self-report measure of Criterion B from the Alternative Model for Personality Disorders. In Study 1, a prototype matching approach was used to aggregate ratings from 15 clinicians specializing in personality disorder treatment and/or assessment. Indices of inter-rater agreement and inter-rater reliability revealed high convergence as to the most important maladaptive facets for malignant narcissism. The scoring procedure, based on additive counts for score computation, included eleven Criterion B facets covering core features of malignant narcissism. Study 2 evaluated the criterion and incremental validity of the scoring procedure in a sample of 288 patients from a personality disorder treatment clinic, as well as in a sample of 1103 participants from the community. In both samples, results from nonparametric mean comparisons, receiver operating characteristic curves, bivariate Pearson correlations, and hierarchical multiple linear regressions showed significant associations between malignant narcissism and broader components of personality functioning, as well as with relevant emotional, relational, and/or behavioral features. This new scoring procedure is a simple and valid method for measuring malignant narcissism, and is suitable for clinical and research settings.
The Impacts of Emotional Intelligence on Students’ Study Habits in Blended Learning Environments: The Mediating Role of Cognitive Engagement during COVID-19

Emotional intelligence is a main area in educational psychology and a key factor in the academic life of students. It deals with deviant behavior through self-awareness and self-motivation, regulates emotional and social skills, and converts emotional energy into positive energy. This study examined direct and indirect relationships between emotional intelligence and study habits in blended learning environments. Blended learning is conceptualized as a hybrid learning approach that combines online learning opportunities and the traditional classroom approach. Furthermore, the study explored the mediating role of cognitive engagement in the relationship between emotional intelligence and study habits. We used 26 items in a paper-based questionnaire in a quantitative study to collect data on emotional intelligence, cognitive engagement and study habits from health sciences students (N = 338) enrolled in blended learning courses in universities in the Hunan province of China. Emotional intelligence included self-awareness, self-motivation, and the regulation of emotion; social skills were also examined. A partial least squares structural-equation modeling approach was applied through SmartPLS software to explore the relationships. The results indicate that self-awareness and self-motivation have direct, significant, and positive connections with study habits. Similarly, the results indicate that all four dimensions of emotional intelligence (self-awareness, self-motivation, emotion regulation and social skills) had indirect, significant, and positive relationships with study habits using cognitive engagement as a mediator variable. It was concluded that students face higher-than-usual challenges in building study habits in blended learning environments during the COVID-19 pandemic, and that emotional intelligence helps them to develop their study habits to greater effect. Similarly, it was concluded that cognitive engagement strengthens the connection between emotional intelligence and study habits. Therefore, it is recommended that universities take specific measures to enhance students’ emotional intelligence and cognitive engagement, which will ultimately improve their study habits. Moreover, valuable and practical implications for teachers, practitioners, and university management were also discussed in the study.
STRESS AND BURNOUT SYNDROME AMONG MOROCCAN MEDICAL STUDENTS: A CROSS-SECTIONAL STUDY

Background:Christina Maslach and colleagues define burnout as a psychological syndrome in response to chronic interpersonal stressors on the job which is further characterized by its three dimensions of exhaustion, depersonalization, and a decreased sense of accomplishment. Burnout and stress are symptomatically similar, with burnout attributed specifically to occupational or academic stressors. Both can cause seriousconsequences on studenthealth, professionalism, and patient care. There are few studies evaluating the level of stress and burnoutsyndrome among medical students in Morocco.The aim of this study was to assess the prevalence and levels of burnout syndrome to identify associated factors as well as the level of stress among a group of medical students in Morocco. Method: Our study was descriptive andcross-sectional. It focused on 5th grade level medical students and was carried out during the month of November 2014. Data was collected through a self-administered questionnaire based on volunteering. Results:The study was conducted in a total of 178 fifth-year medical students. The response rate was 97.2% (n = 173). The mean age was 22.2 years (SD = 0.87 years) with a female predominance (74%). The average daily working hours were 8.33 hours (SD= 2.74) and the average daily hours of sleep was 7 hours (SD= 1.1). The majority of students (96.5%) were single.The prevalence of burnout, based on Maslach Burnout Inventory, was 49% (n = 87) of students.The prevalence of high emotional exhaustion was 44%, high depersonalization was 33.3% and high burnout score for personal accomplishment accounted for 64 %. We found a positive correlation between the number of working hours and the burnout score (r = 0.341, p <0.001) as well as the stress score (r=0.3, p=0.009). We also found a negative correlation between the number of hours of sleep and the Burnout score (r = -0.215, p = 0.019). Clearly, this study provides an idea for necessity to plan specific interventions to reduce student stress and avoid burnout.
Mental Well-Being: 2010–2018 Trends among Italian Adolescents

(1) Aims: To explore temporal trends 2010–2018 of well-being among Italian adolescents and to evaluate potential explanatory factors. (2) Methods: Italian nationality representative samples of students aged 11, 13, and 15 years were recruited in 2010, 2014, and 2018; Health Behaviour in School-aged Children (HBSC), for an overall number of 165,000 teenagers. Multivariable logistic regression models were performed to fit the trends over time of life satisfaction (LS), psychological (PSY-HC) and somatic health complaints (SOM-HC) considering the contextual factors: school work pressure, social support (family, school, peers), socioeconomic status, geographic area, and immigration background; (3) Results: From 2010 to 2018 while LS was steady, health complaints increased, mainly for PSY-HC, in all age and gender groups. Trend of PSY-HC affected mainly 15-years-olds: rates among boys varied from 29.6% to 35.9% (OR: 1.13, 95%CI: 1.02–1.25); among girls from 49.1% to 63.3% (OR: 1.56, 95%CI: 1.42–1.72). High school work pressure and poor social support play a central role in worsening well-being outcomes; (4) Conclusions: Our findings pictured a remarkable worsening trend of teenagers’ well-being, especially among 15-year-old girls. Further research will be required to investigate this breaking up of the connection between psychophysical symptomatology and cognitive perception of life satisfaction.
Perceived Stress at Work and Associated Factors among E-Waste Workers in French-Speaking West Africa

Perceived stress at work is an important risk factor that affects the mental and physical health of workers. This study aims to determine the prevalence and factors associated with perceived stress in the informal electronic and electrical equipment waste processing sector in French-speaking West Africa. From 14 to 21 November 2019, a cross-sectional survey was carried out among e-waste workers in five countries in the French-speaking West African region, and participants were selected by stratified random sampling. Participants were interviewed on socio-demographic variables and characteristics related to e-waste management activities using a questionnaire incorporating Cohen’s Perceived Stress Scale (10-item version). Factors associated with perceived stress were determined by multivariate logistic regression. A total of 740 e-waste workers were interviewed. The mean age of the workers was 34.59 ± 11.65 years, with extremes of 14 and 74 years. Most of the interviewees were repairers (43.11%). The prevalence of perceived stress among the e-waste workers was 76.76%. Insufficient income, number of working days per week, perceived violence at work, and the interference of work with family responsibilities or leisure were the risk factors that were the most associated with perceived stress. The high prevalence of perceived stress and its associated factors call for consideration and improvement of the working conditions of e-waste workers.
Biguanide Pharmaceutical Formulations and the Applications of Bile Acid-Based Nano Delivery in Chronic Medical Conditions

Biguanides, particularly the widely prescribed drug metformin, have been marketed for many decades and have well-established absorption profiles. They are commonly administered via the oral route and, despite variation in oral uptake, remain commonly prescribed for diabetes mellitus, typically type 2. Studies over the last decade have focused on the design and development of advanced oral delivery dosage forms using bio nano technologies and novel drug carrier systems. Such studies have demonstrated significantly enhanced delivery and safety of biguanides using nanocapsules. Enhanced delivery and safety have widened the potential applications of biguanides not only in diabetes but also in other disorders. Hence, this review aimed to explore biguanides’ pharmacokinetics, pharmacodynamics, and pharmaceutical applications in diabetes, as well as in other disorders.
Evaluation of sputum eosinophil count as a predictor of treatment response to mepolizumab

For patients with asthma, eosinophilic airway inflammation is associated with poor lung function, increased disease severity, reduced quality of life and increased risk of exacerbations [1, 2]. As such, several biologic therapies targeting cytokines involved in eosinophil survival and activation have been developed, with the aim of reducing eosinophilic inflammation [3]. The response to these cytokine-targeting biologics has typically been assessed by monitoring clinical outcomes. Reductions in blood eosinophils have also been monitored [2], since these cells are easily accessible and are reflective of eosinophilic airway inflammation [4, 5]. However, the utility of sputum eosinophils as a biomarker for assessing the therapeutic response to biologic therapies remains an area of ongoing scientific debate and has been largely unexplored, owing to logistical challenges associated with their collection and measurement. In patients with severe eosinophilic asthma and sputum eosinophil counts of ≥3–<30%, sputum eosinophils may not represent a more useful biomarker than blood eosinophils for predicting clinical treatment response to mepolizumab https://bit.ly/3pOTw93
Study of radio properties of active galaxies

In this paper we investigate radio properties of active galaxies taken from Veron-Cetty & Veron (2010) catalogue. The galaxies are limited to magnitudes in the range of 12m-19m. We have cross-correlated the list with radio catalogues and selected those galaxies, which have data on 5 radio fluxes at different wavelengths. For all the objects we have built radio spectra and estimate radio spectral indices. As a result, we have αaverage±0.5036±0.0717.
Penile carcinoma: a report of two cases treated by partial penectomy, its effects on quality of life and review of literature

Penile cancer is a rare malignancy worldwide except in parts of Africa, Asia and Latin America where higher incidences have been reported. The disease leads to serious physical disfigurement of the male genitalia which can have debilitating consequences, thus it may alter micturition patterns and impair penetrative sexual intercourse. The lack of cancer registries and epidemiological surveillance programs in Ghana makes estimation of the prevalence in Ghana difficult hence to advance the course of knowledge, awareness and prevention of penile cancers, it is imperative that such cases are brought to the fore and discussed. We report two cases of penile cancer that had partial penectomy and inguinal lymphadenectomy at the Korle Bu Teaching Hospital. Clinical findings and intervention of these reported cases highlight the management process and it further assessed the psychological impact of intervention. The two patients presented to our outpatient department with penile lesions which were confirmed to be penile cancer. The first patient presented with a 30 year history with recurrent ulceration while the other presented with just 1 (one) year history of penile lesion. Both patients required partial penectomy and inguinal lymphadenopathy in the treatment of their condition. The major risk factors as reported in this case study, include uncircumcision, previous treatment for sexually transmitted infections, multiple sexual partners and smoking. Treatment is associated with reduction in sexual function although quality of life may remain satisfactory. Strong family and psychological support are key cornerstones for good treatment outcomes.
The Effect of Rider:Horse Bodyweight Ratio on the Superficial Body Temperature of Horse’s Thoracolumbar Region Evaluated by Advanced Thermal Image Processing

Simple Summary Overloading of the horse’s thoracolumbar region is a serious problem mainly affecting sport and school horses during their daily under-saddle work. As the human population becomes heavier, the effect of rider bodyweight on equine welfare and performance requires further investigation. This study used infrared thermography to assess the effect of rider:horse bodyweight ratio on the horse’s thoracolumbar region by introducing advanced digital image processing. Twelve horses during regular work were ridden by each of six riders assigned to light (L), moderate (M), and heavy (H) groups. Thermal images of the back region were taken before and after standard exercise and underwent conventional analysis and texture analysis where the thermal images were separated into red, green, and blue components. Four areas of the horse’s thoracolumbar region were annotated to represent the withers area, the thoracic spine area, and the left and right areas of back muscles. Among 372 returned features, 75 texture features differed between bodyweight ratio groups, whereas the conventional thermal features did not. Contrary to conventional thermal features, the consistent measurable differences in texture features were evidenced predominantly in the red component of thermal images when the texture heterogeneity measures, such as InvDefMom, SumEntrp, Entropy, DifVarnc, and DifEntrp, were considered. Abstract Appropriate matching of rider–horse sizes is becoming an increasingly important issue of riding horses’ care, as the human population becomes heavier. Recently, infrared thermography (IRT) was considered to be effective in differing the effect of 10.6% and 21.3% of the rider:horse bodyweight ratio, but not 10.1% and 15.3%. As IRT images contain many pixels reflecting the complexity of the body’s surface, the pixel relations were assessed by image texture analysis using histogram statistics (HS), gray-level run-length matrix (GLRLM), and gray level co-occurrence matrix (GLCM) approaches. The study aimed to determine differences in texture features of thermal images under the impact of 10–12%, >12 ≤15%, >15 <18% rider:horse bodyweight ratios, respectively. Twelve horses were ridden by each of six riders assigned to light (L), moderate (M), and heavy (H) groups. Thermal images were taken pre- and post-standard exercise and underwent conventional and texture analysis. Texture analysis required image decomposition into red, green, and blue components. Among 372 returned features, 95 HS features, 48 GLRLM features, and 96 GLCH features differed dependent on exercise; whereas 29 HS features, 16 GLRLM features, and 30 GLCH features differed dependent on bodyweight ratio. Contrary to conventional thermal features, the texture heterogeneity measures, InvDefMom, SumEntrp, Entropy, DifVarnc, and DifEntrp, expressed consistent measurable differences when the red component was considered.
A Review on Precision Polishing Technology of Single-Crystal SiC

Single-crystal SiC is a typical third-generation semiconductor power-device material because of its excellent electronic and thermal properties. An ultrasmooth surface with atomic surface roughness that is scratch free and subsurface damage (SSD) free is indispensable before its application. As the last process to reduce the surface roughness and remove surface defects, precision polishing of single-crystal SiC is essential. In this paper, precision polishing technologies for 4H-SiC and 6H-SiC, which are the most commonly used polytypes of single-crystal SiC, such as chemical mechanical polishing (CMP), photocatalytic chemical mechanical polishing (PCMP), plasma-assisted polishing (PAP), electrochemical mechanical polishing (ECMP), and catalyst-referred etching (CARE), were reviewed and compared with emphasis on the experimental setup, polishing mechanism, material removal rate (MRR), and surface roughness. An atomically smooth surface without SSD can be obtained by CMP, PCMP, PAP, and CARE for single-crystal SiC. However, their MRRs are meager, and the waste treatment after CMP is difficult and expensive. Moreover, PAP’s operation is poor due to the complex polishing system, plasma generation, and irradiation devices. A high MRR can be achieved by ECMP. In addition, it is an environmentally friendly precision polishing process for single-crystal SiC since the neutral salt solution is generally used as the electrolyte in ECMP. However, the formation of the egglike protrusions at the oxide/SiC interface during anodic oxidation would lead to a bigger surface roughness after ECMP than that after PAP is processed. The HF solution used in CARE was toxic, and Pt was particularly expensive. Ultrasonic vibration-assisted single-crystal SiC polishing and electrolyte plasma polishing (EPP) were discussed; furthermore, the research direction of further improving the surface quality and MRR of single-crystal SiC was prospected.
ADAPTATION AND VALIDATION OF THE FEAR OF COVID-19 SCALE FOR FACE-TO-FACE LEARNING

: COVID-19 has had a great impact on higher education due to the fear of contagion. This study aims to present an adapted version of the Fear of COVID-19 Scale (FCV-19S) designed by Ahorsu et al. (2020) to the context of face-to-face learning: Fear of COVID-19 Scale for Face-to-Face Learning (FCV-19S-FL). The FCV-19S was translated into European Portuguese and adapted to the context of face-to-face learning, resulting in a 9-item scale. The sample consists of 534 university students. An explanatory