Miracle-dz/UniFAR-FTUs huggingface dataset:
Rheumatoid Arthritis IL-17 Induces Monocyte Migration in

† Rheumatoid arthritis (RA) is a chronic systemic inﬂammatory disease which is in part mediated by the migration of monocytes from blood to RA synovial tissue, where they differentiate into macrophages and secrete inﬂammatory cytokines and chemokines. The T cell cytokine IL-17 is expressed in the RA synovial tissue and synovial ﬂuid. To better understand the mechanism by which IL-17 might promote inﬂammation, its role in monocyte trafﬁcking was examined. In vivo, IL-17 mediates monocyte migration into sponges implanted into SCID mice. In vitro, IL-17 was chemotactic, not chemokinetic, for monocytes at the concentrations detected in the RA synovial ﬂuid. Further, IL-17-induced monocyte migration was mediated by ligation to IL-17RA and RC expressed on monocytes and was mediated through p38MAPK signaling. Finally, neutralization of IL-17 in RA synovial ﬂuid or its receptors on monocytes signiﬁcantly reduced monocyte migration mediated by RA synovial ﬂuid. These observations suggest that IL-17 may be important in recruiting monocytes into the joints of patients with RA, supporting IL-17 as a therapeutic target in RA. The Journal of Immunology, 2009, 182: 3884–3891. the of isolated the of
ROLE OF WOMEN IN GOAT FARMING IN MID-HILLS OF NEPAL

Goat (Capra hircus) basically Khari goat is one of the components of livestock sector of subsistence farming in Nepal. Subsistence farming of goat practice is shifting towards commercial farming and lead farmers are proceeding towards introducing new breed of goat. Boer goat with high potentiality for good carcass quality has been promoting by the government through its research and development institutions to the farmers. Women play significant roles in the domestic and national socio-economic development of the country. Although some research work has been done on issues of women and gender in agriculture and related sciences, it has been insufficiently addressed and lack to identify actual roles of women’s in goat production and management. Beside this 56% HHs are having migrants with higher percent of male outmigrants added additional burden as well opportunities for women to be involved in different roles in different sectors. This study therefore was designed to examine women’s roles in goats management in the mid hill region of Nepal. Dhading district is one of the Boer goat pocket area, therefore; selected for this study to find out appropriate roles played by women in goat rearing and production systems. To address the genders role in goat farming system, data from the variables related to socio-economic characteristics were analyzed to find out the mean difference and also t value was calculated. Among the selected variables involvement of male, farm land holding size, access to credit and training variables were highly significant at 1 percent. The contribution of economically active age was significant at 1 percent. Involvement of male farmer in Boer goat production was highly significant at 1 percent level of significance. Land area, access to credit and training taken was also highly significant at 1 percent for the adoption of Boer goat. Women in male-headed households rarely that are only 2% have control over income from goat sales. But in case of women headed household especially in subsistence goat farming the primary goal of selling goat and Key Informant and Purposive random sampling was to select VDC and
Impact of Climate and Population Change on Temperature-Related 1 Mortality Burden in Bavaria, Germany 2

Background: Recent studies on temperature-related mortality burden generally found higher 17 cold-related deaths than heat-related deaths. It is anticipated that global warming will on one 18 hand result in larger heat-related mortality but on the other hand lead to less cold-related 19 mortality. Thus, it remains unclear whether the net change in temperature-related mortality 20 burden will increase in the future under climate change. Objectives: We aimed to quantify the impact of climate change on heat-, cold-, and the total 22 temperature-related (net change) mortality burden across five administrative areas in Bavaria 23 by the end of the 21 st century. Methods: We applied location-specific, overall all ages and age-specific exposure-response 25 functions to project the net change in temperature-related mortality burden during the future 26 period 2083-2099 as compared to the baseline period 1990-2006 under four climate scenarios 27 (Representative Concentration Pathway [RCP] 2.6, 4.5, 6.0, and 8.5) and six population 28 projection scenarios (assuming a constant population, Shared Socio-economic Pathway [SSP] 29 1, SSP2, SSP3, SSP4, and SSP5). We further calculated changes in the age-specific 30 temperature-related mortality burden during the future period. 31 Results: When considering the exposure-response function for all ages for mortality projection, 32 the net temperature-related mortality was found to remain similar under SSP1 and SSP2, 33 decrease significantly for SSP3 and SSP4 (under three RCPs -2.6, 4.5 and 6.0) and increase 34 significantly only under SSP5. The highest decline was found for the scenarios of SSP3 and 35 RCP 2.6 where deaths during the future period decreased by 41%, i.e. [-15,382 (95% empirical 36 confidence interval, eCI: -21,364; -8,487)]. However, when considering the age-specific 37 exposure-response functions for mortality projection, the net temperature-related mortality 38 burden was found to increase significantly under all SSPs and RCPs. In consequence, even 39 under the previous highest decrement scenario of SSP3 and RCP 2.6, deaths in the future period
Deep Grasp: Detection and Localization of Grasps with Deep Neural Networks

A deep learning architecture is proposed to predict graspable locations for robotic manipulation. We consider a more realistic situation that none or multiple objects can be in a scene. By transforming grasp configuration regression into classification problem with null hypothesis competition, the deep neural network with RGB-D image input predicts multiple grasp candidates on a single unseen object, as well as predict grasp candidates on multiple novel objects in a single shot. We perform extensive experiments with our framework on different scenarios, including no object, single object, and multi-objects. We compare with state-of-the-art approaches on Cornell dataset, and show we can achieve 96.0\% and 96.1\% accuracy on image-wise split and object-wise split, respectively.
The E00-110 experiment in Jeﬀerson Lab’s Hall A: Deeply Virtual Compton Scattering oﬀ the Proton at 6 GeV

We present ﬁnal results on the photon electroproduction ( (cid:126)ep → epγ ) cross section in the deeply virtual Compton scattering (DVCS) regime and the valence quark region from Jeﬀerson Lab experiment E00-110. Results from an analysis of a subset of these data were published before, but the analysis has been improved which is described here at length, together with details on the experimental setup. Furthermore, additional data have been analyzed resulting in photon electroproduction cross sections at new kinematic settings, for a total of 588 experimental bins. Results of the Q 2 - and x B -dependences of both the helicity-dependent and helicity-independent cross sections are discussed. The Q 2 -dependence illustrates the dominance of the twist-2 handbag amplitude in the kinematics of the experiment, as previously noted. Thanks to the excellent accuracy of this high luminosity experiment, it becomes clear that the unpolarized cross section shows a signiﬁcant deviation from the Bethe-Heitler process in our kinematics, compatible with a large contribution from the leading twist-2 DVCS 2 term to the photon electroproduction cross section. The necessity to include higher-twist corrections in order to fully reproduce the shape of the data is also discussed. The DVCS cross sections in this paper represent the ﬁnal set of experimental results from E00-110, superseding the previous publication.
University of Birmingham RoCK blocks, wreath products and KLR algebras

We consider RoCK (or Rouquier) blocks of symmetric groups and Hecke algebras at roots of unity. We prove a conjecture of Turner asserting that a certain idempotent truncation of a RoCK block of weight d of a symmetric group S n deﬁned over a ﬁeld F of characteristic e is Morita equivalent to the principal block of the wreath product S e (cid:111) S d . This generalises a theorem of Chuang and Kessar that applies to RoCK blocks with abelian defect groups. Our proof relies crucially on an isomorphism between F S n and a cyclotomic Khovanov–Lauda–Rouquier algebra, and the Morita equivalence we produce is that of graded algebras. We also prove the analogous result for an Iwahori– Hecke algebra at a root of unity deﬁned over an arbitrary ﬁeld.
Selection of B Lymphopoiesis Receptor Editing in Positive and Negative

In B lymphopoiesis, Ag receptor expression and signaling are critical to determine developmental progression, survival, and activation. Several positive and negative selection checkpoints to test this receptor have been described in B lymphopoiesis, aiming to ensure the generation of functionally competent, nonautoimmune repertoire. Secondary Ag receptor gene recombination allows B lymphocytes to replace an inappropriate receptor with a new receptor, a mechanism called receptor editing. This salvage mechanism uncouples the Ag receptor fate from that of the cell itself, suggesting that B cell repertoire is regulated by a process of receptor selection. Secondary rearrangements are stimulated in different stages of B cell development, where editing of the receptor is necessary to fulfill stage-specific requirements. In this study, we discuss the contribution of receptor editing in B lymphopoiesis and its regulation by positive and negative selection signals. The Journal of Immunology, 2004, 173: 4265–4271. is requirements
Low Adiponectin Levels and Increased Risk of T2DM in Patients With Myocardial Infarction

OBJECTIVE Patients with acute myocardial infarction (MI) have increased risk of developing type 2 diabetes mellitus (T2DM). Adiponectin is an insulin-sensitizing hormone produced in adipose tissue, directly suppressing hepatic gluconeogenesis, stimulating fatty acid oxidation and glucose uptake in skeletal muscle and insulin secretion. In healthy humans, low plasma adiponectin levels associate with increased risk of T2DM; however, the relationship between adiponectin and T2DM in patients with MI has never been investigated. During developed T2DM. of was analyzed using a competing risk analysis.
Successful Treatment of Immune Thrombocytopenia as an Extrahepatic Manifestation in an HCV-Carrier Woman with Normal Liver Function Test Results

The authors report a case of immune thrombocytopenia (ITP) as an extrahepatic manifestation in a hepatitis C virus (HCV)-carrier woman with normal liver function tests. The 46-year-old woman visited the Preventive Medical Center of International University of Health and Welfare (IUHW) Hospital in February 2011. She had no complaints and a conventional health check was conducted. The physical and laboratory examinations showed results within normal range except for iron-deficiency anemia and positive for HCV antibody (third generation). HCV-RNA (PCR) was 4.20 Log IU/ml, HCV genotype II and HCV core antibody 484.7. These findings suggested chronic infection with HCV, but there seemed to be no involvement of liver disease. Three months later, at the second visit, she showed thrombocytopenia. We believed the thrombocytopenia to be caused by chronic HCV infection and started anti-HCV viral therapy: interferon α2A (90μg) injection weekly and ribavirin (600mg/day). Five months later the treatment was discontinued due to neutropenia even though GCSF injections were frequently administered. After treatment for two months, levels of HCV PCR copies were not detected, and the platelet count recovered to normal after six months. Since then three years have passed, HCV-PCR copies have shown non-detectable levels and the platelet count remains normal. There are numerous papers reporting that HCV causes ITP as an extrahepatic manifestation, but a case report of ITP caused by chronic HCV infection without liver disease has not been found. The present case report discusses the specificity of HCV infection on extrahepatic manifestation, and the treatment of ITP caused by chronic HCV infection
Automatic Generation of Sequence Diagrams and Updating Domain Model from Use Cases

—Software modeling allows for problem decomposition in a way that facilitates analysis and communication of the solution to developers and other interested parties. Models are widely used in engineering in general, but in Software Engineering modeling has often been left out due to the pressures to improve deadlines. A method and a tool that reduce the duration of this phase could help furthering the modeling phase. Use Cases are commonly utilized for functional specifications in Object-Oriented paradigm and the use of markups in Use Cases allow an automatic partial generation of Analysis Models, reducing the time of the modeling phase in this paradigm. This paper proposes a combination of rules for marking up Use Cases and one procedure for generating partial Sequence Diagrams with analysis classes (one Sequence Diagram for each Use Case) and the updating of the Domain Model with operations. A tool was built to prove the concept and two experiments were carried out.
Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity GlyT1 inhibitor and GPR55 agonist.

lysophosphatidic Abstract GPR55 is a G protein-coupled receptor activated by L- α -lysophosphatidylinositol, and suggested to have roles in pain signalling, bone morphogenesis and possibly in vascular endothelial cells. It has affinity for certain cannabinoids (molecules that interact with the cannabinoid CB 1 and CB 2 receptors), but investigation of its functional role in cell-based systems and in tissue has been limited by a lack of selective pharmacological tools. Here, we present our characterisation of GPR55 in the yeast S. cerevisiae and in human embryonic kidney (HEK293) cells. We describe GSK494581A, a selective small-molecule ligand of GPR55 identified through diversity screening. GSK494581A is one of a series of benzoylpiperazines originally identified and patented as inhibitors of the glycine transporter subtype 1 (GlyT1). The structure-activity relationship between GPR55 and GlyT1 is divergent across this series. The most GPR55-selective example is GSK575594A, which is approximately 60-fold selective for GPR55 (pEC 50 = 6.8) over GlyT1 (pIC 50 = 5.0). Several exemplars with activity at GPR55 and GlyT1 have been profiled at a broad range of other molecular targets and are inactive at cannabinoid receptors and all other targets tested. The benzoylpiperazine agonists activate human GPR55 but not rodent GPR55, suggesting that the relatively low level of sequence identity between these orthologues (75%) translates to important functional differences in the ligand-binding site.
Mesenchymal stem cells accelerated growth and metastasis of neuroblastoma and preferentially homed towards both primary and metastatic lociin orthotopic neuroblasoma model CURRENT STATUS: UNDER REVIEW

Majority of neuroblastoma patients develop metastatic disease at diagnosis and their prognosis is poor with current therapeutic approach. Major challenges are how to tackle the mechanisms responsible for tumorigenesis and metastasis. Human mesenchymal stem cells (hMSCs) may be actively involved in the constitution of cancer microenvironment. In our study, an orthotopic neuroblasoma murine model was utilized to mimic the actual scenario. Human neuroblastoma cell line SK-N-LP was transfected with luciferase gene, which were inoculated with/without MSCs into the adrenal area of SCID-beige mice. The growth and metastasis of neuroblastoma was observed by using Xenogen IVIS 100 in vivo imaging and evaluating gross tumors ex vivo . The homing of MSCs towards tumor was analyzed by tracing fluorescence signal tagged on MSCs using CRI maestroTM imaging system. bioluminescence luciferase IVIS Lucifease Interleukin anti-GD2
Voltammetric Determination of Esomeprazole using Carbon Paste Electrode Modified by Nanoparticles Oxide, and its Application on Tablet and Serum

:- The anodic voltammetric behavior of esomeprazole (ESO) was explored at carbon paste electrode modified by mixture of CuO/ZnO nanoparticles (CPE/ CuO ZnO NPs) in B.R buffer (PB) solutions over the pH range (2.0-11.0) using cyclic and linear-sweep voltammetry (CV; LSV). The oxidation of ESO was shown to be irreversible and diffusion-adsorption controlled driven process. Under optimized conditions, the LSV peak currents were in a linear relationship to ESO concentrations in the range of (1x10 -7 M– 1x10 -6 M) with a detection limit of 3.1 x10 -8 M. The LSV was successfully employed for the determination of ESO in tablet. The voltammetric procedure was successfully also applied for rapid analysis of ESO in stability studies without interference from the degradation products.
Lattice Boltzmann Simulation of Immiscible Two-Phase Displacement in Two-Dimensional Berea Sandstone

Understanding the dynamic displacement of immiscible fluids in porous media is important for carbon dioxide injection and storage, enhanced oil recovery, and non-aqueous phase liquid contamination of groundwater. However, the process is not well understood at the pore scale. This work therefore focuses on the effects of interfacial tension, wettability, and the viscosity ratio on displacement of one fluid by another immiscible fluid in a two-dimensional (2D) Berea sandstone using the colour gradient lattice Boltzmann model with a modified implementation of the wetting boundary condition. Through invasion of the wetting phase into the porous matrix, it is observed that the viscosity ratio plays an important role in the non-wetting phase recovery. At the viscosity ratio ( λ ) of unity, the saturation of the wetting fluid is highest, and it linearly increases with time. The displacing fluid saturation reduces drastically when λ increases to 20; however, when λ is beyond 20, the reduction becomes less significant for both imbibition and drainage. The front of the bottom fingers is finally halted at a position near the inlet as the viscosity ratio increases to 10. Increasing the interfacial tension generally results in higher saturation of the wetting fluid. Finally, the contact angle is found to have a limited effect on the efficiency of displacement in the 2D Berea sandstone.
SOME RECENT BACTERIOLOGICAL AND BIOCHEMICAL STUDIES ON DIARRHEA IN NEWLY BORN CALVES WITH SPECIAL REFERENCE TO DNA FRAGMENTATION IN BLOOD

Rectal swabs and blood samples were collected from (100) diarrheic calves and (20) apparently healthy contact calves using sterile cotton swabs, at different farms in Sharkia Governorate. For hematological and biochemical investigations, a total of 20 blood samples with and without EDTA from healthy animals showed negative bacterial isolation (group 1) and 50blood samples were selected from collected blood samples (100) from animals showed positive bacterial isolation (group 2). Bacteriological examination of fecal samples revealed that E coli was the most prominent cause of calf diarrhea at an incidence of 54.1 %,followed by Salmonella species at an incidence of 17.5 % then Campylobacter at an incidence of 10.8 %. Proteus valgaris was isolated at an incidence of 10 % then Pseudomonas at an incidence of 6.7 %. Serological identification of 65 E. coli isolates, revealed that the E. coli were typed as O157 (38.5%), O119 (23.1%), O25 (7.7), O111 (7.7%), O186 (15.4%), and untypable E. coli (7.7%). Bacteriological examination revealed the isolation of Salmonella from diarrheic calves as well as apparently healthy contact calves. S. typhimurium was the most predominant serovars (52.4%) which indicates that S. typhimurium is the most predominant serovars causing enteritis in calves. S. enteritidis (33.3%) and 3 strains (14.3%) were untypable. Results of antibiogram revealed that, ciprofloxacin, cephalexin and ofloxacin( were the most effective antibiotics for treatment of diarrheic calves. Most isolated bacteria showed different degrees of resistance to Ampicillin, Cefotaxime, Gentamycine. PCR results revealed that 16 (88.9%) out of 18 examined E coli strains encoding blaTEM gene while only two (11.1%) strains were negative. The hematological changes revealed that there was a significant decrease in total red blood cells count, platelets and hemoglobin concentration (p < 0.05) accompanied by higher values of Total leukocyte count (TLC), neutrophilia with lymphopenia recorded in diarrheic calves in comparison with control. Biochemical analysis of positive cases revealed significant increase (P<0.05) in serum globulin content and decrease in total protein, albumin content, resulting in altered A/G ratio, also there was significant increase in urea, creatinine and potassium accompanied by significant decrease in glucose and sodium. In comparison with control amino acid analysis demonstrated significant (P<0.05) decrease in diseased calves. Inter nucleosomal cleavage of host cell DNA, indicated evidence of apoptosis, there was a direct relationship between DNA fragmentation and malondialdehyde level (MDA) while inverse relation with antioxidants.
Mobile technologies make education a part of everyday life

Purpose The purpose of this paper is to show the effectiveness of innovative mobile technologies in learning, to develop a new testing system with a mobile application and to investigate the influence of its use on the level of students’ knowledge. Design/methodology/approach Modern information assessment methods of knowledge, testing, including application of mobile devices and statistical analysis tools were used in the present research. Findings In recent times, students are motivated to use mobile technologies in education. This paper offers one of the approaches for achieving the effective integration of mobile technologies into the learning process. The software is developed for in-class testing as a client-server and its mobile application. Practical implications The practical research verified many advantages of mobile device usage during testing. It contributes to higher academic performance; in addition, it is economically advantageous as it does not require special equipment in classrooms and is psychologically comfortable for students who are accustomed to constantly using their mobile devices. Social implications Well-educated people play a role in the development of modern society. Mobile technologies can transform education into a seamless part of the ordinary life so that a person does not recognize it as training at all. The learning process will become more natural and easier and that will improve its quality. Originality/value This paper demonstrates how mobile devices can satisfy the learning expectations of students who frequently use mobile services on the Web and can attract their study interest implementing the created testing system in full-time education process.
GENERATION Y ON THE LABOUR MARKET: REGIONAL ANALYSIS OF THE VISEGRAD GROUP COUNTRIES

Despite the great potential to become good employees, the European Generation Y faces difficulties in entering and remaining on the labour market, with the result that young people are increasingly becoming unemployed. On the basis of an analysis of the unemployment of the young population in NUTS2 regions of the Visegrad Group countries, executed with help of a multi-criteria indicator, it is clear that the worst situation exists in the peripheral regions of Poland, Hungary and Slovakia. From the point of view of countries, the best situation is in the Czech Republic, while in the other countries the conditions are very similar in terms of the perceptible territorial diversification of the levels of individual regions.