Miracle-dz/UniFAR-FTUs huggingface dataset:
Absolute Risk and Attributable Fraction of Type-Specific Human Papillomavirus in Cervical Cancer and Precancerous Lesions—A Population-Based Study of 6286 Women in Rural Areas of China

Background: To investigate the human papillomavirus (HPV) genotype distribution among the general population and assess the attribution of HPV genotypes targeted by vaccines to protect against cervical lesions theoretically. Methods: Cervical samples were collected from women aged 21 to 64 years old from Inner Mongolia and Shanxi Province in China who had not been vaccinated against HPV. HPV type-specific absolute risk (AR) to classified cervical lesions was calculated and then the attributable fraction (AF) was estimated, together with the combined contributions of the HPV types, targeted by four available HPV vaccines and five HPV vaccines in clinical trials in China to protect against cervical lesions. Results: A total of 6286 women with an average age of 44.1 years ± 8.41 (range: 21–64) participated in the study. The age distribution of 14 HR-HPV and HPV16/18 all showed a ‘U’ shape, which peaked in the ≤25 year-group and >55 year-group. The five most common genotypes were HPV16 (4.3%), HPV52 (4.1%), HPV58 (2.1%), HPV51 (2.1%), and HPV66 (1.7%). The prevalence of HPV types 6 and 11 infections was 1.1% and observed with n significant differences across age stratifications in China. AF to CIN2+ was predominated by HPV 16 with 56.2%, followed by HPV58 (12.0%), HPV52 (8.5%), HPV18 (4.3%), and HPV51 (2.9%). HPV52 and 58 in the prophylactic HPV vaccine would enhance the protection against CIN2+ by approximately 20%. Conclusions: Regarding multi-valent HPV vaccine development in China, the HPV types 16, 52, 58, and 18 should be given priority for their high prevalence at the population level, high AR, notable AF, and high relative risk to high-grade cervical lesions.
Exploring the Biology of Cancer-Associated Fibroblasts in Pancreatic Cancer

Simple Summary This review summarises the current understanding of cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDAC). The aim of this review is to discuss recent advances in CAF biology, the various roles of CAFs, and different CAF subtypes. We will also examine the evolution of CAFs as tumours progress, and the relationship between CAFs and other cell types within PDAC tumours. Finally, we will provide an update on the potential for therapeutic targeting of certain aspects of CAF biology, and discuss future directions for this exciting and rapidly-progressing field. Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy characterised by a stubbornly low 5-year survival which is essentially unchanged in the past 5 decades. Despite recent advances in chemotherapy and surgical outcomes, progress continues to lag behind that of other cancers. The PDAC microenvironment is characterised by a dense, fibrotic stroma of which cancer-associated fibroblasts (CAFs) are key players. CAFs and fibrosis were initially thought to be uniformly tumour-promoting, however this doctrine is now being challenged by a wealth of evidence demonstrating CAF phenotypic and functional heterogeneity. Recent technological advances have allowed for the molecular profiling of the PDAC tumour microenvironment at exceptional detail, and these technologies are being leveraged at pace to improve our understanding of this previously elusive cell population. In this review we discuss CAF heterogeneity and recent developments in CAF biology. We explore the complex relationship between CAFs and other cell types within the PDAC microenvironment. We discuss the potential for therapeutic targeting of CAFs, and we finally provide an overview of future directions for the field and the possibility of improving outcomes for patients with this devastating disease.
A SCUBA survey of Orion -the low-mass end of the core mass function

We have re-analysed all of the Submillimetre Common User Bolometer Array (SCUBA) archive data of the Orion star-forming regions. We have put together all of the data taken at different times by different groups. Consequently, we have constructed the deepest submillimetre maps of these regions ever made. There are four regions that have been mapped: Orion A North and South, and Orion B North and South. We find that two of the regions, Orion A North and Orion B North, have deeper sensitivity and completeness limits, and contain a larger number of sources, so we concentrate on these two. We compare the data with archive data from the Spitzer Space Telescope to determine whether or not a core detected in the submillimetre is pre-stellar in nature. We extract all of the pre-stellar cores from the data and make a histogram of the core masses. This can be compared to the stellar initial mass function (IMF). We find the high-mass core mass function (CMF) follows a roughly Salpeter-like slope, just like the IMF, as seen in previous work. Our deeper maps allow us to see that the CMF turns over at, ? 1.3 M? about a factor of 4 higher than our completeness limit. This turnover has never previously been observed, and is only visible here due to our much deeper maps. It mimics the turnover seen in the stellar IMF at ? 0.1 M? The low-mass side of the CMF is a power law with an exponent of, 0.35
MRSA and Skin Infections in Psoriatic Patients: Therapeutic Options and New Perspectives

Psoriatic patients present various infectious risk factors, but there are few studies in the literature evaluating the actual impact of psoriasis in severe staphylococcal skin infections. Our narrative review of the literature suggests that psoriatic patients are at increased risk of both colonization and severe infection, during hospitalization, by S. aureus. The latter also appears to play a role in the pathogenesis of psoriasis through the production of exotoxins. Hospitalized psoriatic patients are also at increased risk of MRSA skin infections. For this reason, new molecules are needed that could both overcome bacterial resistance and inhibit exotoxin production. In our opinion, in the near future, topical quorum sensing inhibitors in combination with current anti-MRSA therapies will be able to overcome the increasing resistance and block exotoxin production. Supplementation with Vitamin E (VE) or derivatives could also enhance the effect of anti-MRSA antibiotics, considering that psoriatic patients with metabolic comorbidities show a low intake of VE and low serum levels, making VE supplementation an interesting new perspective.
Psychological Distress in Patients Treated for Renal Cell Carcinoma: A Systematic Literature Review

(1) Background: The incidence of psychological distress and its impact on renal cell carcinoma (RCC) patients is unclear. Our aim was to analyze the literature regarding the prevalence of psychological distress and its impact on patients with non-metastatic or metastatic RCC; (2) Methods: A systematic search of five databases was performed. Studies were considered eligible if they included patients with RCC, had a prospective or retrospective design, and assessed anxiety, depression, or psychological distress at any time during treatment or follow-up. Exclusion criteria: no treatment for RCC, or not providing data for RCC patients; (3) Results: A total of 15 studies were included. Reported psychological distress was up to 77% and the prevalence of depressive and anxiety symptoms were up to 77.6% and 68.3% in patients with non-metastatic RCC. There was no association of depression with overall survival (OS) in patients with non-metastatic RCC treated by radical nephrectomy; on the contrary, in patients with metastatic disease, depression had an impact on OS. Limitations are related to the quality of the included studies; (4) Conclusions: Patients with RCC reported a high level of psychological distress like other cancer patients. It seems that for patients with localized disease, psychological distress does not impact OS, while it does in those with metastatic disease.
The maximum modulus principle for CR functions

Let M be a CR submanifold of C" without extreme points. Then, the modulus of any CR function on M cannot have a strong local maximum at any point of M. Preliminaries. Let M be a smooth manifold embedded as a locally closed real submanifold of C'. We denote by aM the tangential Cauchy-Riemann operator on M induced by the Cauchy-Riemann operator a on Cn and with HTp(M) the holomorphic tangent space to M at a point p E M. Let us recall some of the definitions and results of [4]. DEFINITION 1. aM obeys the local maximum modulus principle on M if given any open connected set U in M and any u differentiable in U such that aMu = 0 on U, then u cannot have a (weak) local maximum at any point of U unless u is constant on U. DEFINITION 2. We call a point p E M an extreme point of M if there exists a local holomorphic coordinate system z = (zI, ., Zn) in a neighborhood U of p such that z(p) = 0 and M n U c {zly, > O}. Here we assume that locally near p, M is not contained in any Ck for k < n. DEFINITION 3. (i) For any p E M and X E HTp(M) set Z = X iY, where Y = JX E HTp(M) and J is the multiplication with (_1)1/2 which defines the complex structure on R2n. The Levi form at p assigns to Z the normal vector Lp(Z) defined by Lp(Z) = Bp(X, X) + Bp(Y, Y), where Bp is the second fundamental form of M at p. (ii) We denote Np(M) as the normal space of M at p. For any t E Np(M) the map Lt defined by Lt(Z) = (Lp(Z), () is called the Levi form of M at p in the ( direction. Here K ) represents the real inner product in r}2 n1 We assume that p = 0 and codim RM = q. Then in a neighborhood U of the origin there are smooth real functions P1, . , Pq such that dp, A . A dpq1o * 0 and M n U {Z E uIp(z)= * = Pq(Z) =O}. We may assume that dp1(0),. , dpq(O) are orthonormal. Received by the editors September 27, 1984 and, in revised form, March 13, 1985. 1980 Mathematics Subject Classification. Primary 32F25. t1986 American Mathematical Society 0002-9939/86 $1.00 + $. 25 per page
LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease

Genetic alterations in the LRRK2 gene, encoding leucine-rich repeat kinase 2, are a common risk factor for Parkinson’s disease. How LRRK2 alterations lead to cell pathology is an area of ongoing investigation, however, multiple lines of evidence suggest a role for LRRK2 in lipid pathways. It is increasingly recognized that in addition to being energy reservoirs and structural entities, some lipids, including neural lipids, participate in signaling cascades. Early investigations revealed that LRRK2 localized to membranous and vesicular structures, suggesting an interaction of LRRK2 and lipids or lipid-associated proteins. LRRK2 substrates from the Rab GTPase family play a critical role in vesicle trafficking, lipid metabolism and lipid storage, all processes which rely on lipid dynamics. In addition, LRRK2 is associated with the phosphorylation and activity of enzymes that catabolize plasma membrane and lysosomal lipids. Furthermore, LRRK2 knockout studies have revealed that blood, brain and urine exhibit lipid level changes, including alterations to sterols, sphingolipids and phospholipids, respectively. In human LRRK2 mutation carriers, changes to sterols, sphingolipids, phospholipids, fatty acyls and glycerolipids are reported in multiple tissues. This review summarizes the evidence regarding associations between LRRK2 and lipids, and the functional consequences of LRRK2-associated lipid changes are discussed.
$P$-alcoves and nonemptiness of affine Deligne-Lusztig varieties

We study affine Deligne-Lusztig varieties in the affine flag manifold of an algebraic group, and in particular the question, which affine Deligne-Lusztig varieties are non-empty. Under mild assumptions on the group, we provide a complete answer to this question in terms of the underlying affine root system. In particular, this proves the corresponding conjecture for split groups stated in G\"ortz et al. (2010). The question of non-emptiness of affine Deligne-Lusztig varieties is closely related to the relationship between certain natural stratifications of moduli spaces of abelian varieties in positive characteristic.
THE EFFECT OF CORPORATE GOVERNANCE ON FINANCIAL PERFORMANCE: CORPORATE SOCIAL RESPONSIBILITY AS A BUFFER

This study aims to demonstrate the role of CSR in moderating the influence of corporate governance on financial performance. Furthermore, the researchers compared the corporate governance of Islamic banks in Indonesia and Malaysia. Data analysis used Moderate Regression Analysis and independent t-test analysis. The research data is the financial statements of each Islamic bank in Indonesia and Malaysia from 201 to 2020. This study shows that CSR cannot moderate the financial performance of Indonesian and Malaysian Islamic companies. Another result states that there is no difference in the implementation of corporate governance in Indonesian and Malaysian Islamic banks. CSR is becoming an important aspect of the business community. But does not support the company's financial performance. Nevertheless, this remains a common concern because of the importance of natural sustainability and a balanced economy.
Systemic Lupus in males – clinical-laboratory, immunological and histological characteristics.

Systemic lupus erythematosus is a chronic, systemic, non-organ-specific autoimmune disease that affects all organs and systems of the human body and is characterized by the production of autoantibodies against nuclear antigens. Its prevalence in Europe reaches 1:2500. It affects mostly women (female : male ratio=9 : 1) in fertile age group (15-45 years). The clinical course of lupus in males is characterized by more aggressive clinical course and the development of serious complications, such as vasculitis, central nervous system involvement, antiphospholipid syndrome, etc. For the period of 7 years (2012-2019) we observed overall 18 male patients with systemic lupus, 11 with biopsy-proven renal involvement and 7 without clinically significant renal disease (proteinuria < 0.5 g/24 h., no erythrocyturia/cylindruria, normal renal function), mean age at the diagnosis 39.6 +/- 12.3 years. All patients received pathogenetic treatment (corticosteroids + cytotoxic agents). Three had secondary antiphospholipid syndrome, 1 – inflammatory bowel disease, 1 – seronegative spondyloarthropathy. Three had type 2 diabetes. The authors discuss the clinical, immunological and histological characteristics and the therapeutic approach in males with systemic lupus.
Fatty Acid and Antioxidant Profile of Eggs from Pasture-Raised Hens Fed a Corn- and Soy-Free Diet and Supplemented with Grass-Fed Beef Suet and Liver

There is increasing interest in using grass-fed beef (GFB) by-products to augment the nutrient profile of eggs among local pasture-raising systems in the US. The objective of this study was to characterize egg yolk fatty acid and antioxidant profiles using eggs from pasture-raised hens fed a corn- and soy-free diet and supplemented with GFB suet and liver compared to eggs from pasture-raised hens fed a corn and soy layer hen feed and commercially obtained cage-free eggs. The egg yolk vitamin and mineral profile was also assessed by a commercial laboratory. Both pasture-raised groups had twice as much carotenoid content, three times as much omega-3 fatty acid content, and a 5–10 times lower omega-6:omega-3 fatty acid ratio compared to the cage-free eggs (p < 0.001). Eggs from hens fed a corn- and soy-free feed and GFB by-products had half as much omega-6 fatty acid content and five times more conjugated linoleic acid, three times more odd-chain fatty acid, and 6–70 times more branched-chain fatty acid content (p < 0.001). Feeding pasture-raised hens GFB suet and liver reduces agricultural waste while producing improved egg products for consumers, but further research is needed to quantify optimal supplementation levels and the efficacy of corn- and soy-free diets.
Measuring Online Social Support: Development and Validation of a Short Form for Chinese Adolescents

Supportive interactions on social media have great potential to benefit adolescents’ development. However, there is no instrument to measure online social support (OSS) in China. The study aimed to develop and validate a Chinese short version of the Online Social Support Scale (OSSS). The original scale was translated into Chinese through multiple forward and backward translation protocols. The calibration sample (N = 262) was used to select items and test the reliability, validity, and internal structure of the short form. The cross-validation sample (N = 267) was then used to assess measurement invariance by multigroup confirmatory factor analysis and examine criterion validity based on its relationships with life satisfaction, depression, and time on social media. The 20-item Chinese short version of OSSS (OSSS-CS) includes four factors: esteem/emotional support, social companionship, informational support, and instrumental support. Our results suggest that the OSSS-CS has high internal consistency, construct validity, and criterion validity. Furthermore, evidence of partial cross-validity demonstrated invariance of the variance–covariance matrices, factor structure, factor loadings, and factor variance across independent samples. The results also revealed that the original OSSS could be replicated across cultures. Finally, the short form developed in the study can be used as a reliable and valid measure of online social support among the Chinese adolescent population.
The Pristine Dwarf-Galaxy survey – II. In-depth observational study of the faint Milky Way satellite Sagittarius II

We present an extensive study of the Sagittarius II (Sgr II) stellar system using MegaCam g and i photometry, narrow-band, metallicity-sensitive calcium H&K doublet photometry and Keck II/DEIMOS multiobject spectroscopy. We derive and refine the Sgr II structural and stellar properties inferred at the time of its discovery. The colour–magnitude diagram implies Sgr II is old (12.0 ± 0.5 Gyr) and metal poor. The CaHK photometry confirms the metal-poor nature of the satellite ([Fe/H] CaHK = −2.32 ± 0.04 dex) and suggests that Sgr II hosts more than one single stellar population ($\sigma _\mathrm{[FeH]}^\mathrm{CaHK} = 0.11^{+0.05}_{-0.03}$ dex). Using the Ca infrared triplet measured from our highest signal-to-noise spectra, we confirm the metallicity and dispersion inferred from the Pristine photometric metallicities ([Fe/H]spectro = −2.23 ± 0.05 dex, $\sigma _\mathrm{[Fe/H]}^\mathrm{spectro} = 0.10 ^{+0.06}_{-0.04}$ dex). The velocity dispersion of the system is found to be $\sigma _{v} = 2.7^{+1.3}_{-1.0} {\rm \, km \,\, s^{-1}}$ after excluding two potential binary stars. Sgr II’s metallicity and absolute magnitude (MV = −5.7 ± 0.1 mag) place the system on the luminosity–metallicity relation of the Milky Way dwarf galaxies despite its small size. The low but resolved metallicity and velocity dispersions paint the picture of a slightly dark-matter-dominated satellite ($M/L = 23.0^{+32.8}_{-23.0}$ M⊙ L$^{-1}_{\odot }$). Furthermore, using the Gaia Data Release 2, we constrain the orbit of the satellite and find an apocentre of $118.4 ^{+28.4}_{-23.7} {\rm \, kpc}$ and a pericentre of $54.8 ^{+3.3}_{-6.1} {\rm \, kpc}$. The orbit of Sgr II is consistent with the trailing arm of the Sgr stream and indicates that it is possibly a satellite of the Sgr dSph that was tidally stripped from the dwarf’s influence.
High-Resolution Numerical Simulations of a Large-Scale Helium Plume Using Adaptive Mesh Refinement

The physical characteristics and evolution of a large-scale helium plume are examined through a series of numerical simulations with increasing physical resolution using adaptive mesh refinement (AMR). The five simulations each model a 1~m diameter circular helium plume exiting into a (4~m)$^3$ domain, and differ solely with respect to the smallest scales resolved using the AMR, spanning resolutions from 15.6~mm down to 0.976~mm. As the physical resolution becomes finer, the helium-air shear layer and subsequent Kelvin-Helmholtz instability are better resolved, leading to a shift in the observed plume structure and dynamics. In particular, a critical resolution is found between 3.91~mm and 1.95~mm, below which the mean statistics and frequency content of the plume are altered by the development of a Rayleigh-Taylor instability near the centerline in close proximity to the base of the plume. This shift corresponds to a plume "puffing" frequency that is slightly higher than would be predicted using empirical relationships developed for buoyant jets. Ultimately, the high-fidelity simulations performed here are intended as a new validation dataset for the development of subgrid-scale models used in large eddy simulations of real-world buoyancy-driven flows.
Two-photon photoassociation spectroscopy of the 
Σ+2
 YbLi molecular ground state

We report on measurements of the binding energies of several weakly bound vibrational states of the paramagnetic $^{174}$Yb$^{6}$Li molecule in the electronic ground state using two-photon spectroscopy in an ultracold atomic mixture confined in an optical dipole trap. We theoretically analyze the experimental spectrum to obtain an accurate description of the long-range potential of the ground state molecule. Based on the measured binding energies, we arrive at an improved value of the interspecies $s$-wave scattering length $a_{s0}=30$ $a_0$. Employing coherent two-photon spectroscopy we also observe the creation of ''dark'' atom-molecule superposition states in the heteronuclear Yb-Li system. This work is an important step towards the efficient production of ultracold YbLi molecules via association from an ultracold atomic mixture.
Capecitabine and temozolomide for metastatic intermediate to high-grade pancreatic neuroendocrine neoplasm: a single center experience

Background/Aims The combination of capecitabine and temozolomide (CAPTEM) is one of the treatment options for metastatic pancreatic neuroendocrine neoplasms (pNENs). This study aims to evaluate the efficacy of CAPTEM in patients with metastatic intermediate to high-grade pancreatic neuroendocrine tumor (pNET) or carcinoma (pNEC). Methods This study was conducted retrospectively in a single center. Patients were treated for intermediate to high-grade tumor with 750 mg/m2 of capecitabine twice daily from day 1 to 14 and 200 mg/m2 of temozolomide once daily from day 10 to 14, repeating twice in a cycle of 28 days. The primary outcomes were durations of overall survival (OS) and progression-free survival (PFS). The secondary outcomes consisted of objective response rate and disease control rate. Results A total of 12 patients (grade 2 NET in six, grade 3 NET in three, NEC in three patients) who received CAPTEM were included in this study. Patients received a median of five cycles (range, 2 to 46) of CAPTEM. The median dose combined 1,150 mg of capecitabine and 300 mg of temozolomide. The median OS and PFS were 41.2 months (range, 3.2 to 167) and 39.7 months (range, 2.1 to 100), respectively. Patients with NET had longer OS and PFS compared to those of patients with NEC (p = 0.002 and p = 0.028). High Ki-67 proliferative index (> 50%) was significantly associated with poor survival outcomes. Conclusions CAPTEM showed favorable survival outcomes in patients with metastatic intermediate to high-grade pNENs. Our study supports that CAPTEM may be an effective treatment option for metastatic pNENs.