Miracle-dz/UniFAR-FTUs huggingface dataset:
Convergence characteristics of proportional-type iterative learning control in the sense of Lebesgue-p norm

This article studies convergence characteristics of first- and second-order P-type (proportional-type) iterative learning control laws for a class of partially known linear time-invariant systems with a direct feed-through term. In the study, the tracking error is measured in the sense of Lebesgue-p norm, based on which the concepts of the Qp factor and the convergence speed are specified. For the first-order updating law, the monotone convergence is achieved by means of the generalised Young inequality of convolution integral. Moreover, for the second-order updating rule, the convergence is also verified and its speed is compared with the first-order law. Through analysis, it is quantitatively noted that both the system dynamics and the learning gains affect the convergence. It is also observed that the iterative learning process with the second-order law can be Qp-faster, Qp-equivalent or Qp-slower than the system with the first-order rule, depending on the selected learning gains. Numerical simulation manifests the validity and the effectiveness.
Theory of choice

Part 1 Choosing options: the problem of choosing options formal model. Part 2 Choice mechanisms and functions: properties of choice functions pair-dominant mechanisms choice by preference relations criterion extremization algorithms various forms of pair-dominant choice mechanisms proofs of theorems. Part 3 Examples of choice mechanisms: generalization of the concept multi-criteria choice mechanisms tournament choice concluding remarks proofs of theorems. Part 3 Classes of choice mechanisms: non-classical structures (hyper relations) choice rules on non-classical structures classes of choice mechanisms some special non-classic choice mechanisms proofs of theorems. Part 5 Operations over choice functions: problem outline basic definitions closedness of choice function space superposition of choice functions choice function approximation concluding remarks proofs of theorems. Part 6 Voting theory: formal statement problem outline characteristic properties of L-operators closedness of domains mechanisms generating L-operators explicit definition of L-operators list representation of L-operators proof of theorems concluding remarks.
Attitude of basic education students towards peers with educa tional special needs

The article is the result of a study that aimed to describe the attitude of students from the Dolores Sucre Basic Education School, in the city of Azogues, towards the inclusion of Peers With Special Educational Needs, associated with disability. To evaluate th is attitude, the Chedoke-McMaster CATCH Scale Attitude towards Children with Dis abilities
Impact of sky conditions on net ecosystem productivity of a “floating blanket” wetland in southwest China

Based on eddy covariance (EC) measurements from 2016 to 2020, the impact of sky conditions on net ecosystem 10 productivity (NEP) over Beihai wetland was examined. Sky conditions were classified into sunny, cloudy and overcast skies. On half-hourly timescale, the daytime NEP responds to the changing total photosynthetically active radiation (PAR t ) more efficiently under cloudy and overcast conditions than sunny conditions across seasons. Compared with sunny conditions, the apparent quantum yield (α) under overcast (cloudy) conditions increased 342.9% (271.4%) in spring, 17.6% (20.6%) in summer, 280.0% (230.0%) in autumn and 125.0% (25.0%) in winter, respectively. Unlike the patterns of half-hourly NEP, the 15 daily NEP was significantly lower under overcast conditions than that under cloudy and sunny conditions. And the daily NEP peaked under cloudy skies when the clearness index (CI) fluctuated around 0.3-0.6. Additionally, the ecosystem light use efficiency (LUE) and water use efficiency (WUE) also changed with the variations in sky conditions. The daily LUE and WUE reached their maximum values under overcast (CI: 0-0.2) and cloudy conditions (CI: 0.2-0.4), respectively. NEP was mainly controlled by the diffuse photosynthetically active radiation (PAR d ) and air temperature (Ta), and the direct photosynthetically 20 active radiation (PAR b ) had a secondary effect on NEP from to Path variations of NEP on half-hourly, daily and monthly timescale, meanwhile, the relative contribution of Ta to NEP varied considerably across different timescales, ranging from 18.4% (half-hourly timescales) to 50.3% (monthly timescales). The increase in VPD inhibited NEP, and 1.9%-16.8% of the variation of NEP explicated by from half-hourly to monthly timescales.
Frequency-dependent signaling in cardiac myocytes

Background: Recent experimental data support the view that signaling activity at the membrane depends on its geometric parameters such as surface area and curvature. However, a mathematical, biophysical concept linking shape to receptor signaling is missing. The membranes of cardiomyocytes are constantly reshaped due to cycles of contraction and relaxation. According to constant-volume behavior of cardiomyocyte contraction, the length shortening is compensated by Z-disc myofilament lattice expansion and dynamic deformation of membrane between two adjacent Z-discs. Both morphological changes are strongly dependent on the frequency of contraction. Here, we developed the hypothesis that dynamic geometry of cardiomyocytes could be important for their plasticity and signaling. This effect may depend on the frequency of the beating heart and may represent a novel concept to explain how changes in frequency affect cardiac signaling. Methods: This hypothesis is almost impossible to answer with experiments, as the in-vitro cardiomyocytes are almost two-dimensional and flattened rather than being in their real in-vivo shape. Therefore, we designed a COMSOL multiphysics program to mathematically model the dynamic geometry of a human cardiomyocyte and explore whether the beating frequency can modulate membrane signal transduction. Src kinase is an important component of cardiac mechanotransduction. We first presented that Src mainly localizes at costameres. Then, the frequency-dependent signaling effect was studied mathematically by numerical simulation of Src-mediated PDGFR signaling pathway. The reaction-convection-diffusion partial differential equation was formulated to simulate PDGFR pathway in a contracting sarcomeric disc for a range of frequencies from 1 to 4 Hz. Results: Simulations exhibits higher concentration of phospho-Src when a cardiomyocyte beats with higher rates. The calculated phospho-Src concentration at 4, 2, and 1 Hz beat rates, comparing to 0 Hz, was 21.5%, 9.4%, and 4.7% higher, respectively. Conclusion: Here we provide mathematical evidence for a novel concept in biology. Cell shape directly translates into signaling, an effect of importance particularly for the myocardium, where cells continuously reshape their membranes. The concept of locality of surface-to-volume ratios is demonstrated to lead to changes in membrane-mediated signaling and may help to explain the remarkable plasticity of the myocardium in response to biomechanical stress.
Stress Detection from Social Media Articles: New Dataset Benchmark and Analytical Study

Stress detection is a basic and essential task for examining the mental health of a given population. With the rapid digitalization leading to text-based forms of communication gaining dominance over spoken ones, there is now the chance to develop analytical studies for stress detection directly from textual inputs in social media. However, only a limited number of benchmarks are publicly available. To this end, we create four high quality datasets based on Twitter and Reddit, which are designed particularly for the task of stress detection from social media texts. The main contributions are three-folds: 1) for each dataset, we provide a detailed description on our dataset construction process, including data collection, data preprocessing and annotation; 2) we perform a comparative study on the performance of different rule-based and machine learning-based approaches on the proposed datasets as the new benchmark of this field; 3) we study the feasibility and reliability of existing systems. Extensive experiments show that Transformer-based models outperform lexical-based and embedding-based methods. Also, we observe that existing methods based on sentiment polarity detection cannot be directly adapted to the task of stress detection and there remains space for further improvements. We hope this study could pave the way for future studies in the field of computational stress detection.
Effects of the peripheral CB1 receptor antagonist JD5037 in mono— and polytherapy with the AMPK activator metformin in a monocrotaline-induced rat model of pulmonary hypertension

Pulmonary hypertension (PH) is a disease leading to increased pressure in the pulmonary artery and right heart failure. The adenosine monophosphate-activated protein kinase (AMPK) activator, metformin, has a protective effect against PH. CB1 receptor blockade reduces the number of pathological alterations in experimental lung fibrosis. The current study evaluates the effect of the peripheral cannabinoid CB1 receptor antagonist JD5037 in mono- and polytherapy with metformin in rat monocrotaline-induced mild PH. Animals received metformin (100 mg/kg), JD5037 (3 mg/kg), or a combination of both once daily for 21 days. Monocrotaline (60 mg/kg) increased right ventricular (RV) systolic pressure (RVSP), led to RV and lung hypertrophy and remodeling, and decreased oxygen saturation. Metformin partially restored the monocrotaline-induced effects, i.e., decreased RVSP, increased oxygen saturation, and counteracted cardiac fibrotic, hypertrophic, and inflammatory changes. JD5037 modified parameters related to inflammation and/or fibrosis. Only polytherapy with metformin and JD5037 improved Fulton’s index and coronary artery hypertrophy and tended to be more effective than monotherapy against alterations in RVSP, oxygen saturation and coronary artery tunica media vacuolization. In conclusion, monotherapy with JD5037 does not markedly influence the PH-related changes. However, polytherapy with metformin tends to be more efficient than any of these compounds alone.
A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes

Existing immune signatures and tumor mutational burden have only modest predictive capacity for the efficacy of immune check point inhibitors. In this study, we developed an immune-metabolic signature suitable for personalized ICI therapies. A classifier using an immune-metabolic signature (IMMETCOLS) was developed on a training set of 77 metastatic colorectal cancer (mCRC) samples and validated on 4,200 tumors from the TCGA database belonging to 11 types. Here, we reveal that the IMMETCOLS signature classifies tumors into three distinct immune-metabolic clusters. Cluster 1 displays markers of enhanced glycolisis, hexosamine byosinthesis and epithelial-to-mesenchymal transition. On multivariate analysis, cluster 1 tumors were enriched in pro-immune signature but not in immunophenoscore and were associated with the poorest median survival. Its predicted tumor metabolic features suggest an acidic-lactate-rich tumor microenvironment (TME) geared to an immunosuppressive setting, enriched in fibroblasts. Cluster 2 displays features of gluconeogenesis ability, which is needed for glucose-independent survival and preferential use of alternative carbon sources, including glutamine and lipid uptake/β-oxidation. Its metabolic features suggest a hypoxic and hypoglycemic TME, associated with poor tumor-associated antigen presentation. Finally, cluster 3 is highly glycolytic but also has a solid mitochondrial function, with concomitant upregulation of glutamine and essential amino acid transporters and the pentose phosphate pathway leading to glucose exhaustion in the TME and immunosuppression. Together, these findings suggest that the IMMETCOLS signature provides a classifier of tumors from diverse origins, yielding three clusters with distinct immune-metabolic profiles, representing a new predictive tool for patient selection for specific immune-metabolic therapeutic approaches.
Algebraic Geometry: A First Course

1: Affine and Projective Varieties. 2: Regular Functions and Maps. 3: Cones, Projections, and More About Products. 4: Families and Parameter Spaces. 5: Ideals of Varieties, Irreducible Decomposition. 6: Grassmannians and Related Varieties. 7: Rational Functions and Rational Maps. 8: More Examples. 9: Determinantal Varieties. 10: Algebraic Groups. 11: Definitions of Dimension and Elementary Examples. 12: More Dimension Computations. 13: Hilbert Functions and Polynomials. 14: Smoothness and Tangent Spaces. 15: Gauss Maps, Tangential and Dual Varieties. 16: Tangent Spaces to Grassmannians. 17: Further Topics Involving Smoothness and Tangent Spaces. 18: Degree. 19: Further Examples and Applications of Degree. 20: Singular Points and Tangent Cones. 21: Parameter Spaces and Moduli Spaces. 22: Quadrics.
Neural activity patterns in the chemosensory network encoding vomeronasal and olfactory information in mice

Rodents detect chemical information mainly through the olfactory and vomeronasal systems, which play complementary roles to orchestrate appropriate behavioral responses. To characterize the integration of chemosensory information, we have performed electrophysiological and c-Fos studies of the bulbo–amygdalar network in freely behaving female mice exploring neutral or conspecific stimuli. We hypothesize that processing conspecifics stimuli requires both chemosensory systems, and thus our results will show shared patterns of activity in olfactory and vomeronasal structures. Were the hypothesis not true, the activity of the vomeronasal structures would be independent of that of the main olfactory system. In the c-Fos analysis, we assessed the activation elicited by neutral olfactory or male stimuli in a broader network. Male urine induced a significantly higher activity in the vomeronasal system compared to that induced by a neutral odorant. Concerning the olfactory system, only the cortex–amygdala transition area showed significant activation. No differential c-Fos expression was found in the reward system and the basolateral amygdala. These functional patterns in the chemosensory circuitry reveal a strong top-down control of the amygdala over both olfactory bulbs, suggesting an active role of the amygdala in the integration of chemosensory information directing the activity of the bulbs during environmental exploration.
Integrative analysis of synovial sarcoma transcriptome reveals different types of transcriptomic changes

Background: Synovial sarcoma (SS) is a rare and aggressive cancer that can come from distinct soft tissue types including muscle and ligaments. However, the transcriptomic landscape of SS is still poorly understood. This study aimed to systematically dissect the changes in SS transcriptome from different perspectives. Methods: We performed deep total RNA sequencing on ten paired Synovial sarcoma and tumor-adjacent tissues to systematically dissect the transcriptomic profile of SS in terms of gene expression, alternative splicing, gene fusion, and circular RNAs. Results: A total of 2,309 upregulated and 1,977 downregulated genes were identified between SS and tumor-adjacent tissues. Those upregulated genes could lead to the upregulation of the cell cycle, ribosome, and DNA replication pathways, while the downregulated genes may result in the downregulation of a set of metabolic biological processes and signaling pathways. Moreover, 2,511 genes (including 21 splicing factors) were differentially alternative spliced, indicating that the deregulation of alternative splicing could be one important factor that contributes to tumorigenesis. Additionally, we identified the known gene fusions of SS18-SSX1/SSX2 as well as 11 potentially novel gene fusions. Interestingly, 49 circular RNAs were differentially expressed and their parental genes could function in muscle contraction and muscle system processes. Conclusions: Collectively, our comprehensive dissection of the transcriptomic changes of SS from both transcriptional and post-transcriptional levels provides novel insights into the biology and underlying molecular mechanism of SS.
Zero Bound, Option-Implied PDFs, and Term Structure Models

This paper points out that several known ways of modeling non-negative nominal interest rates lead to different implications for the risk-neutral distribution of the short rate that can be checked with options data. In particular, Black's boundary models ("interest rates as options") imply a probability density function (pdf) that contains a Dirac delta function and a cumulative distribution function (cdf) that is nonzero at the zero boundary, while models like the CIR and positive-definite quadratic-Gaussian (QG) models have a zero cdf at the boundary. Eurodollar futures options data are found to favor Black's boundary models: the CIR/QG models, even multifactor versions, have difficulty capturing option prices accurately not only in low interest rate environments but also in higher interest rate environments, and data in early 2008 provide an almost tangible signature of the Dirac delta function in Black's boundary pdf models. Options data also contradict the prediction of well-known models whose cdf is zero at the zero boundary, namely that the risk-neutral pdf is always positively skewed.
Forearc tectonics and volcanism during the Devonian–Carboniferous evolution of the North Patagonian segment, southern Chile (41,3°S)

Late Paleozoic to early Mesozoic subduction complexes formed during the evolution of southwestern Gondwana and extensively crop out along the Chilean continental margin. Recent findings in northern Patagonia (40°–43°S) revealed that accretionary processes were active since the Devonian when enhanced lithosphere stretching in the forearc led to the formation of Chaitenia island arc. The extension in the crust consecutively developed a backarc basin, which culminated during a compressive episode that re-amalgamated the Chaitenia island arc with the margin. This episode produced intermediate grade metamorphism in the sedimentary rocks that were formed throughout the extension. To constrain the tectonic evolution of these processes, we combined petrology, structural analysis, whole-rock geochemical, and whole-rock isotopic tracing (Sr-Nd-Pb) data along with thermodynamic modelling. Two petro-tectonic domains are here defined. The Western Coastal Range Domain is composed of Carboniferous to Permian metapsammopelitic rocks, which are mainly schists with a metasedimentary Carboniferous protolith exhibiting a penetrative northeast to southwest dipping main foliation associated with basal accretion. The Eastern Coastal Range Domain is comprised by garnet micaschists, metabasalts, metarhyolites, and metasandstones. This unit is folded by three ductile structures: The first is related to rootless isoclinal folds, the second is associated with kilometric scale west-verging tight folds, and the third is associated with west-verging cylindrical folds. The volcanic rocks of this domain are comprised by middle Devonian alkaline metarhyolites and metabasalts with enriched-MORB and normal-MORB affinities. Trace element composition suggests that the metabasalts formed through shallow melting in an extensional setting over a supra-subduction zone. Nd and Pb isotope data point to a mantle source change for the basaltic melts from an EM1-like to a DM-like and are interpreted to reflect the embryonic to mature evolution of the early Devonian to Carboniferous backarc system. The calculated P–T evolution of the garnet micaschists follows: 1) a clockwise IP–IT prograde Barrovian path, 2) an isobaric thermal increase at ∼7 kbar and 540°C, and 3) an adiabatic decompression. Finally, after the metamorphism, these rocks were uplifted by thrusting processes that probably occurred during the late Permian.
Treatment of Periprosthetic Joint Infection and Fracture-Related Infection With a Temporary Arthrodesis Made by PMMA-Coated Intramedullary Nails – Evaluation of Technique and Quality of Life in Implant-Free Interval

Background Antimicrobial coating of intramedullary nails with polymethyl methacrylate (PMMA) bone cement promises infection control and stabilization for subsequent bone healing. However, when removing the implant, bone cement can debond and remain in the medullary cavity of the long bones, representing a nidus for reinfection. This work presents a technique comprising reinforcement of PMMA-coated intramedullary nails with cerclage wire to prevent such problems in patients treated for fracture-related infection (FRI) or knee periprosthetic joint infection (PJI) with a static spacer as temporary arthrodesis allowing weight-bearing in the implant-free interval. Outcomes of this surgical treatment were evaluated in terms of (i) associated complications and (ii) patient-reported quality of life. Methods In this retrospective case series, 20 patients with PJI (n = 14, 70%) and FRI (n = 6, 30%) treated with PMMA-coated intramedullary nails reinforced with cerclage wire between January 2021 and July 2021 were included. Quality of life during the implant-free interval was evaluated with the EQ-5D, SF-36, and an ICD-10 based psychological symptom rating and compared with previously analyzed cohorts of successfully treated PJI and FRI patients in whom eradication of infection and stable bone consolidation was achieved. Results Complications during the implant-free interval comprised a broken nail in one case (5.0%) and a reinfection in one case (5.0%). Coating-specific side effects and cement debonding during removal did not occur. The mean physical health component score of SF-36 was 26.1 ± 7.6, and the mean mental health component score reached a value of 47.1 ± 18.6. The mean EQ-5D index value was 0.36 ± 0.32 and the mean EQ-5D visual analogue scale rating was 47.4 ± 19.4. The scores were significantly lower than those in the successfully treated FRI cohort but not in the PJI cohort. The mean ICD-10-based symptom rating scores revealed psychological symptom burden on the depression scale and enhanced levels of anxiety in comparison with healed FRI and PJI patients. Conclusion Reinforcement of PMMA bone cement-coated implants seems to be a reasonable treatment option to create a temporary arthrodesis, preventing detachment of the bone cement when the implant was removed. Level of Evidence: IV.